id category name description xref provided_by synonym deprecated iri same_as subsets GO:0099593 biolink:BiologicalProcess endocytosed synaptic vesicle to endosome fusion Fusion of an endocytosed synaptic vesicle with an endosome. go.json http://purl.obolibrary.org/obo/GO_0099593 GO:0099592 biolink:BiologicalProcess endocytosed synaptic vesicle processing via endosome The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. go.json synaptic vesicle processing via endosome involved in synaptic vesicle recycling http://purl.obolibrary.org/obo/GO_0099592 GO:0099590 biolink:BiologicalProcess neurotransmitter receptor internalization A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor. go.json http://purl.obolibrary.org/obo/GO_0099590 GO:0002621 biolink:BiologicalProcess positive regulation of non-professional antigen presenting cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. go.json activation of non-professional antigen presenting cell antigen processing and presentation|stimulation of non-professional antigen presenting cell antigen processing and presentation|up regulation of non-professional antigen presenting cell antigen processing and presentation|up-regulation of non-professional antigen presenting cell antigen processing and presentation|upregulation of non-professional antigen presenting cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002621 GO:0099533 biolink:BiologicalProcess positive regulation of presynaptic cytosolic calcium concentration Any process that increases the concentration of calcium ions in the presynaptic cytosol. go.json http://purl.obolibrary.org/obo/GO_0099533 goslim_synapse GO:0051599 biolink:BiologicalProcess response to hydrostatic pressure Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. go.json response to biomechanical stress|response to static fluid pressure http://purl.obolibrary.org/obo/GO_0051599 GO:0099534 biolink:MolecularActivity calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations. go.json calcium ion binding involved in regulation of presynaptic cytosolic calcium levels|presynaptic calcium ion buffering|regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering http://purl.obolibrary.org/obo/GO_0099534 goslim_synapse GO:0002622 biolink:BiologicalProcess regulation of B cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation. go.json regulation of B lymphocyte antigen processing and presentation|regulation of B-cell antigen processing and presentation|regulation of B-lymphocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002622 GO:0051597 biolink:BiologicalProcess response to methylmercury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. go.json response to CH3-Hg+|response to MeHg+ http://purl.obolibrary.org/obo/GO_0051597 GO:0002623 biolink:BiologicalProcess negative regulation of B cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation. go.json down regulation of B cell antigen processing and presentation|down-regulation of B cell antigen processing and presentation|downregulation of B cell antigen processing and presentation|inhibition of B cell antigen processing and presentation|negative regulation of B lymphocyte antigen processing and presentation|negative regulation of B-cell antigen processing and presentation|negative regulation of B-lymphocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002623 GO:0099531 biolink:BiologicalProcess presynaptic process involved in chemical synaptic transmission The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0099531 gocheck_do_not_annotate|goslim_synapse GO:0051598 biolink:BiologicalProcess meiotic recombination checkpoint signaling A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes. go.json meiotic recombination checkpoint|pachytene checkpoint|signal transduction involved in meiotic recombination checkpoint http://purl.obolibrary.org/obo/GO_0051598 GO:0099532 biolink:BiologicalProcess synaptic vesicle endosomal processing The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. go.json synaptic vesicle processing via endosome http://purl.obolibrary.org/obo/GO_0099532 goslim_synapse GO:0002624 biolink:BiologicalProcess positive regulation of B cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation. go.json activation of B cell antigen processing and presentation|positive regulation of B lymphocyte antigen processing and presentation|positive regulation of B-cell antigen processing and presentation|positive regulation of B-lymphocyte antigen processing and presentation|stimulation of B cell antigen processing and presentation|up regulation of B cell antigen processing and presentation|up-regulation of B cell antigen processing and presentation|upregulation of B cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002624 GO:0099530 biolink:MolecularActivity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. go.json G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099530 goslim_synapse GO:0002620 biolink:BiologicalProcess negative regulation of non-professional antigen presenting cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. go.json down regulation of non-professional antigen presenting cell antigen processing and presentation|down-regulation of non-professional antigen presenting cell antigen processing and presentation|downregulation of non-professional antigen presenting cell antigen processing and presentation|inhibition of non-professional antigen presenting cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002620 GO:0002629 biolink:BiologicalProcess negative regulation of proteolysis associated with antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. go.json down regulation of proteolysis associated with antigen processing and presentation|down-regulation of proteolysis associated with antigen processing and presentation|downregulation of proteolysis associated with antigen processing and presentation|inhibition of proteolysis associated with antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002629 GO:0051591 biolink:BiologicalProcess response to cAMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. go.json response to 3',5' cAMP|response to 3',5'-cAMP|response to adenosine 3',5'-cyclophosphate|response to cyclic AMP http://purl.obolibrary.org/obo/GO_0051591 GO:0051592 biolink:BiologicalProcess response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. go.json response to Ca2+ ion http://purl.obolibrary.org/obo/GO_0051592 GO:0099539 biolink:BiologicalProcess neuropeptide secretion from presynapse The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration. go.json neuropeptide secretion from presynapse via dense core granule exocytosis http://purl.obolibrary.org/obo/GO_0099539 goslim_synapse GO:0051590 biolink:BiologicalProcess positive regulation of neurotransmitter transport Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of neurotransmitter transport|stimulation of neurotransmitter transport|up regulation of neurotransmitter transport|up-regulation of neurotransmitter transport|upregulation of neurotransmitter transport http://purl.obolibrary.org/obo/GO_0051590 GO:0002625 biolink:BiologicalProcess regulation of T cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. go.json regulation of T lymphocyte antigen processing and presentation|regulation of T-cell antigen processing and presentation|regulation of T-lymphocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002625 GO:0099537 biolink:BiologicalProcess trans-synaptic signaling Cell-cell signaling in either direction across the synaptic cleft. go.json http://purl.obolibrary.org/obo/GO_0099537 goslim_synapse GO:0051595 biolink:BiologicalProcess response to methylglyoxal Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. go.json response to pyruvaldehyde http://purl.obolibrary.org/obo/GO_0051595 GO:0051596 biolink:BiologicalProcess methylglyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. MetaCyc:METHGLYUT-PWY|MetaCyc:Methylglyoxal-Detoxification go.json methylglyoxal breakdown|methylglyoxal catabolism|methylglyoxal degradation http://purl.obolibrary.org/obo/GO_0051596 GO:0099538 biolink:BiologicalProcess synaptic signaling via neuropeptide Cell-cell signaling to or from a synapse, mediated by a peptide. go.json http://purl.obolibrary.org/obo/GO_0099538 goslim_synapse GO:0002626 biolink:BiologicalProcess negative regulation of T cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. go.json down regulation of T cell antigen processing and presentation|down-regulation of T cell antigen processing and presentation|downregulation of T cell antigen processing and presentation|inhibition of T cell antigen processing and presentation|negative regulation of T lymphocyte antigen processing and presentation|negative regulation of T-cell antigen processing and presentation|negative regulation of T-lymphocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002626 GO:0051593 biolink:BiologicalProcess response to folic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. go.json cellular response to folate|cellular response to vitamin B9 http://purl.obolibrary.org/obo/GO_0051593 GO:0002627 biolink:BiologicalProcess positive regulation of T cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. go.json activation of T cell antigen processing and presentation|positive regulation of T lymphocyte antigen processing and presentation|positive regulation of T-cell antigen processing and presentation|positive regulation of T-lymphocyte antigen processing and presentation|stimulation of T cell antigen processing and presentation|up regulation of T cell antigen processing and presentation|up-regulation of T cell antigen processing and presentation|upregulation of T cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002627 GO:0099535 biolink:CellularComponent synapse-associated extracellular matrix The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. go.json extra-synaptic extracellular matrix http://purl.obolibrary.org/obo/GO_0099535 goslim_synapse GO:0002628 biolink:BiologicalProcess regulation of proteolysis associated with antigen processing and presentation Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002628 GO:0099536 biolink:BiologicalProcess synaptic signaling Cell-cell signaling to, from or within a synapse. go.json http://purl.obolibrary.org/obo/GO_0099536 goslim_drosophila|goslim_synapse GO:0051594 biolink:BiologicalProcess detection of glucose The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal. go.json glucose detection|glucose perception|glucose sensing http://purl.obolibrary.org/obo/GO_0051594 GO:0099544 biolink:CellularComponent perisynaptic space The extracellular region immediately adjacent to to a synapse. go.json extrasynaptic space http://purl.obolibrary.org/obo/GO_0099544 goslim_synapse GO:0002632 biolink:BiologicalProcess negative regulation of granuloma formation Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation. go.json down regulation of granuloma formation|down-regulation of granuloma formation|downregulation of granuloma formation|inhibition of granuloma formation http://purl.obolibrary.org/obo/GO_0002632 GO:0002633 biolink:BiologicalProcess positive regulation of granuloma formation Any process that activates or increases the frequency, rate, or extent of granuloma formation. go.json activation of granuloma formation|stimulation of granuloma formation|up regulation of granuloma formation|up-regulation of granuloma formation|upregulation of granuloma formation http://purl.obolibrary.org/obo/GO_0002633 GO:0099545 biolink:BiologicalProcess trans-synaptic signaling by trans-synaptic complex Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex. go.json http://purl.obolibrary.org/obo/GO_0099545 goslim_synapse GO:0002634 biolink:BiologicalProcess regulation of germinal center formation Any process that modulates the frequency, rate, or extent of germinal center formation. go.json http://purl.obolibrary.org/obo/GO_0002634 GO:0099542 biolink:BiologicalProcess trans-synaptic signaling by endocannabinoid Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand. go.json http://purl.obolibrary.org/obo/GO_0099542 goslim_synapse GO:0002635 biolink:BiologicalProcess negative regulation of germinal center formation Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation. go.json down regulation of germinal center formation|down-regulation of germinal center formation|downregulation of germinal center formation|inhibition of germinal center formation http://purl.obolibrary.org/obo/GO_0002635 GO:0099543 biolink:BiologicalProcess trans-synaptic signaling by soluble gas Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft. go.json http://purl.obolibrary.org/obo/GO_0099543 goslim_synapse GO:0099540 biolink:BiologicalProcess trans-synaptic signaling by neuropeptide Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. go.json http://purl.obolibrary.org/obo/GO_0099540 goslim_synapse GO:0099541 biolink:BiologicalProcess trans-synaptic signaling by lipid Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. go.json http://purl.obolibrary.org/obo/GO_0099541 goslim_synapse GO:0002630 biolink:BiologicalProcess positive regulation of proteolysis associated with antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. go.json activation of proteolysis associated with antigen processing and presentation|stimulation of proteolysis associated with antigen processing and presentation|up regulation of proteolysis associated with antigen processing and presentation|up-regulation of proteolysis associated with antigen processing and presentation|upregulation of proteolysis associated with antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002630 GO:0002631 biolink:BiologicalProcess regulation of granuloma formation Any process that modulates the frequency, rate, or extent of granuloma formation. go.json http://purl.obolibrary.org/obo/GO_0002631 GO:0099548 biolink:BiologicalProcess trans-synaptic signaling by nitric oxide Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. go.json http://purl.obolibrary.org/obo/GO_0099548 goslim_synapse GO:0002636 biolink:BiologicalProcess positive regulation of germinal center formation Any process that activates or increases the frequency, rate, or extent of germinal center formation. go.json activation of germinal center formation|stimulation of germinal center formation|up regulation of germinal center formation|up-regulation of germinal center formation|upregulation of germinal center formation http://purl.obolibrary.org/obo/GO_0002636 GO:0099549 biolink:BiologicalProcess trans-synaptic signaling by carbon monoxide Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide. go.json http://purl.obolibrary.org/obo/GO_0099549 goslim_synapse GO:0002637 biolink:BiologicalProcess regulation of immunoglobulin production Any process that modulates the frequency, rate, or extent of immunoglobulin production. go.json regulation of antibody production|regulation of immunoglobulin biosynthetic process|regulation of immunoglobulin secretion http://purl.obolibrary.org/obo/GO_0002637 GO:0002638 biolink:BiologicalProcess negative regulation of immunoglobulin production Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. go.json down regulation of immunoglobulin production|down-regulation of immunoglobulin production|downregulation of immunoglobulin production|inhibition of immunoglobulin production|negative regulation of immunoglobulin biosynthetic process|negative regulation of immunoglobulin secretion http://purl.obolibrary.org/obo/GO_0002638 GO:0099546 biolink:BiologicalProcess protein catabolic process, modulating synaptic transmission Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0099546 goslim_synapse GO:0099547 biolink:BiologicalProcess regulation of translation at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the synapse. go.json http://purl.obolibrary.org/obo/GO_0099547 goslim_synapse GO:0002639 biolink:BiologicalProcess positive regulation of immunoglobulin production Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. go.json activation of immunoglobulin production|positive regulation of immunoglobulin biosynthetic process|positive regulation of immunoglobulin secretion|stimulation of immunoglobulin production|up regulation of immunoglobulin production|up-regulation of immunoglobulin production|upregulation of immunoglobulin production http://purl.obolibrary.org/obo/GO_0002639 GO:0099511 biolink:MolecularActivity voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel. go.json http://purl.obolibrary.org/obo/GO_0099511 goslim_synapse GO:0002600 biolink:BiologicalProcess positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. go.json activation of antigen processing and presentation of lipid antigen via MHC class Ib|positive regulation of lipid antigen processing and presentation via MHC class Ib|stimulation of antigen processing and presentation of lipid antigen via MHC class Ib|up regulation of antigen processing and presentation of lipid antigen via MHC class Ib|up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib|upregulation of antigen processing and presentation of lipid antigen via MHC class Ib http://purl.obolibrary.org/obo/GO_0002600 GO:0099512 biolink:CellularComponent supramolecular fiber A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. go.json fibril http://purl.obolibrary.org/obo/GO_0099512 GO:0002601 biolink:BiologicalProcess regulation of antigen processing and presentation of polysaccharide antigen via MHC class II Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. go.json regulation of polysaccharide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002601 GO:0099510 biolink:MolecularActivity calcium ion binding involved in regulation of cytosolic calcium ion concentration The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations. go.json regulation of cytosolic calcium ion concentration by calcium ion buffering http://purl.obolibrary.org/obo/GO_0099510 GO:0002602 biolink:BiologicalProcess negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. go.json down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II|down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II|downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II|inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II|negative regulation of polysaccharide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002602 GO:0099519 biolink:BiologicalProcess dense core granule cytoskeletal transport The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments. go.json dense core vesicle cytoskeletal trafficking http://purl.obolibrary.org/obo/GO_0099519 GO:0002607 biolink:BiologicalProcess regulation of myeloid dendritic cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002607 GO:0002608 biolink:BiologicalProcess negative regulation of myeloid dendritic cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. go.json down regulation of myeloid dendritic cell antigen processing and presentation|down-regulation of myeloid dendritic cell antigen processing and presentation|downregulation of myeloid dendritic cell antigen processing and presentation|inhibition of myeloid dendritic cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002608 GO:0002609 biolink:BiologicalProcess positive regulation of myeloid dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. go.json activation of myeloid dendritic cell antigen processing and presentation|stimulation of myeloid dendritic cell antigen processing and presentation|up regulation of myeloid dendritic cell antigen processing and presentation|up-regulation of myeloid dendritic cell antigen processing and presentation|upregulation of myeloid dendritic cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002609 GO:0099517 biolink:BiologicalProcess synaptic vesicle transport along microtubule The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. go.json http://purl.obolibrary.org/obo/GO_0099517 goslim_synapse GO:0099518 biolink:BiologicalProcess vesicle cytoskeletal trafficking The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. go.json cytoskeletal fiber-based vesicle localization|vesicle cytoskeletal transport http://purl.obolibrary.org/obo/GO_0099518 GO:0002603 biolink:BiologicalProcess positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. go.json activation of antigen processing and presentation of polysaccharide antigen via MHC class II|positive regulation of polysaccharide antigen processing and presentation via MHC class II|stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II|up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II|up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II|upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II http://purl.obolibrary.org/obo/GO_0002603 GO:0099515 biolink:BiologicalProcess actin filament-based transport The transport of organelles or other particles from one location in the cell to another along actin filaments. go.json http://purl.obolibrary.org/obo/GO_0099515 GO:0099516 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099516 GO:0002604 biolink:BiologicalProcess regulation of dendritic cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002604 GO:0002605 biolink:BiologicalProcess negative regulation of dendritic cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. go.json down regulation of dendritic cell antigen processing and presentation|down-regulation of dendritic cell antigen processing and presentation|downregulation of dendritic cell antigen processing and presentation|inhibition of dendritic cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002605 GO:0099513 biolink:CellularComponent polymeric cytoskeletal fiber A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. go.json http://purl.obolibrary.org/obo/GO_0099513 GO:0099514 biolink:BiologicalProcess synaptic vesicle cytoskeletal transport The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. go.json http://purl.obolibrary.org/obo/GO_0099514 goslim_synapse GO:0002606 biolink:BiologicalProcess positive regulation of dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. go.json activation of dendritic cell antigen processing and presentation|stimulation of dendritic cell antigen processing and presentation|up regulation of dendritic cell antigen processing and presentation|up-regulation of dendritic cell antigen processing and presentation|upregulation of dendritic cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002606 GO:0002610 biolink:BiologicalProcess regulation of plasmacytoid dendritic cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002610 GO:0099522 biolink:CellularComponent cytosolic region Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol. go.json region of cytosol http://purl.obolibrary.org/obo/GO_0099522 gocheck_do_not_annotate GO:0002611 biolink:BiologicalProcess negative regulation of plasmacytoid dendritic cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. go.json down regulation of plasmacytoid dendritic cell antigen processing and presentation|down-regulation of plasmacytoid dendritic cell antigen processing and presentation|downregulation of plasmacytoid dendritic cell antigen processing and presentation|inhibition of plasmacytoid dendritic cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002611 GO:0099523 biolink:CellularComponent presynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the presynapse. go.json http://purl.obolibrary.org/obo/GO_0099523 goslim_synapse GO:0099520 biolink:MolecularActivity monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. go.json ion antiporter activity involved in regulation of pre-synaptic membrane potential|ion antiporter activity involved in regulation of presynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099520 goslim_synapse GO:0002612 biolink:BiologicalProcess positive regulation of plasmacytoid dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. go.json activation of plasmacytoid dendritic cell antigen processing and presentation|stimulation of plasmacytoid dendritic cell antigen processing and presentation|up regulation of plasmacytoid dendritic cell antigen processing and presentation|up-regulation of plasmacytoid dendritic cell antigen processing and presentation|upregulation of plasmacytoid dendritic cell antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002612 GO:0099521 biolink:MolecularActivity ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. go.json ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential|ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099521 goslim_synapse GO:0002613 biolink:BiologicalProcess regulation of monocyte antigen processing and presentation Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002613 GO:0002618 biolink:BiologicalProcess positive regulation of macrophage antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. go.json activation of macrophage antigen processing and presentation|stimulation of macrophage antigen processing and presentation|up regulation of macrophage antigen processing and presentation|up-regulation of macrophage antigen processing and presentation|upregulation of macrophage antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002618 GO:0002619 biolink:BiologicalProcess regulation of non-professional antigen presenting cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002619 GO:0099528 biolink:MolecularActivity G protein-coupled neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G-protein coupled neurotransmitter receptor activity http://purl.obolibrary.org/obo/GO_0099528 GO:0099529 biolink:MolecularActivity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel). go.json http://purl.obolibrary.org/obo/GO_0099529 goslim_synapse GO:0099526 biolink:BiologicalProcess presynapse to nucleus signaling pathway The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). go.json presynaptic signaling to nucleus http://purl.obolibrary.org/obo/GO_0099526 goslim_synapse GO:0002614 biolink:BiologicalProcess negative regulation of monocyte antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. go.json down regulation of monocyte antigen processing and presentation|down-regulation of monocyte antigen processing and presentation|downregulation of monocyte antigen processing and presentation|inhibition of monocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002614 GO:0002615 biolink:BiologicalProcess positive regulation of monocyte antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. go.json activation of monocyte antigen processing and presentation|stimulation of monocyte antigen processing and presentation|up regulation of monocyte antigen processing and presentation|up-regulation of monocyte antigen processing and presentation|upregulation of monocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002615 GO:0099527 biolink:BiologicalProcess postsynapse to nucleus signaling pathway The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). go.json postsynaptic signaling to nucleus http://purl.obolibrary.org/obo/GO_0099527 goslim_synapse GO:0002616 biolink:BiologicalProcess regulation of macrophage antigen processing and presentation Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002616 GO:0099524 biolink:CellularComponent postsynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099524 goslim_synapse GO:0002617 biolink:BiologicalProcess negative regulation of macrophage antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. go.json down regulation of macrophage antigen processing and presentation|down-regulation of macrophage antigen processing and presentation|downregulation of macrophage antigen processing and presentation|inhibition of macrophage antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002617 GO:0099525 biolink:BiologicalProcess presynaptic dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. go.json http://purl.obolibrary.org/obo/GO_0099525 goslim_synapse GO:0099577 biolink:BiologicalProcess regulation of translation at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. go.json http://purl.obolibrary.org/obo/GO_0099577 goslim_synapse GO:0099578 biolink:BiologicalProcess regulation of translation at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099578 goslim_synapse GO:0099575 biolink:BiologicalProcess regulation of protein catabolic process at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. go.json http://purl.obolibrary.org/obo/GO_0099575 goslim_synapse GO:0099576 biolink:BiologicalProcess regulation of protein catabolic process at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099576 goslim_synapse GO:0099573 biolink:CellularComponent glutamatergic postsynaptic density The post-synaptic specialization of a glutamatergic excitatory synapse. go.json postsynaptic specialization, glutamatergic neuron-to-neuron synapse http://purl.obolibrary.org/obo/GO_0099573 goslim_synapse GO:0099574 biolink:BiologicalProcess regulation of protein catabolic process at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating protein degradation at the synapse. go.json http://purl.obolibrary.org/obo/GO_0099574 goslim_synapse GO:0099571 biolink:CellularComponent postsynaptic cytoskeleton The portion of the cytoskeleton contained within the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099571 goslim_synapse GO:0099572 biolink:CellularComponent postsynaptic specialization A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. go.json http://purl.obolibrary.org/obo/GO_0099572 goslim_synapse GO:0099579 biolink:MolecularActivity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential. go.json G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099579 goslim_synapse GO:0099588 biolink:BiologicalProcess positive regulation of postsynaptic cytosolic calcium concentration Any process that increases the concentration of calcium ions in the postsynaptic cytosol. go.json http://purl.obolibrary.org/obo/GO_0099588 goslim_synapse GO:0099589 biolink:MolecularActivity serotonin receptor activity Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. go.json http://purl.obolibrary.org/obo/GO_0099589 GO:0099586 biolink:BiologicalProcess release of sequestered calcium ion into postsynaptic cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol. go.json http://purl.obolibrary.org/obo/GO_0099586 goslim_synapse GO:0099587 biolink:BiologicalProcess inorganic ion import across plasma membrane The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol. go.json inorganic ion import into cell http://purl.obolibrary.org/obo/GO_0099587 GO:0099585 biolink:BiologicalProcess release of sequestered calcium ion into presynaptic cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol. go.json http://purl.obolibrary.org/obo/GO_0099585 goslim_synapse GO:0099582 biolink:MolecularActivity neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol. go.json neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0099582 goslim_synapse GO:0099583 biolink:MolecularActivity neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. go.json neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0099583 goslim_synapse GO:0099580 biolink:MolecularActivity monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. go.json ion antiporter activity involved in regulation of post-synaptic membrane potential|ion antiporter activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099580 goslim_synapse GO:0099581 biolink:MolecularActivity ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. go.json ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential|ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099581 goslim_synapse GO:0099555 biolink:BiologicalProcess trans-synaptic signaling by nitric oxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099555 goslim_synapse GO:0099556 biolink:BiologicalProcess trans-synaptic signaling by carbon monoxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099556 goslim_synapse GO:0099553 biolink:BiologicalProcess trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099553 goslim_synapse GO:0099554 biolink:BiologicalProcess trans-synaptic signaling by soluble gas, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099554 goslim_synapse GO:0099551 biolink:BiologicalProcess trans-synaptic signaling by neuropeptide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099551 goslim_synapse GO:0099552 biolink:BiologicalProcess trans-synaptic signaling by lipid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099552 goslim_synapse GO:0099550 biolink:BiologicalProcess trans-synaptic signaling, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099550 goslim_synapse GO:0099559 biolink:BiologicalProcess maintenance of alignment of postsynaptic density and presynaptic active zone The process by which alignment between postsynaptic density and presynaptic active zone is maintained. go.json http://purl.obolibrary.org/obo/GO_0099559 goslim_synapse GO:0099557 biolink:BiologicalProcess trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099557 goslim_synapse GO:0099558 biolink:BiologicalProcess maintenance of synapse structure A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. go.json synaptic maintenance http://purl.obolibrary.org/obo/GO_0099558 goslim_synapse GO:0099566 biolink:BiologicalProcess regulation of postsynaptic cytosolic calcium ion concentration Any process that regulates the concentration of calcium in the postsynaptic cytosol. go.json regulation of postsynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0099566 goslim_synapse GO:0099567 biolink:MolecularActivity calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations. go.json calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels|postsynaptic calcium ion buffering|regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering http://purl.obolibrary.org/obo/GO_0099567 goslim_synapse GO:0099564 biolink:BiologicalProcess modification of synaptic structure, modulating synaptic transmission Any process that modulates synaptic transmission via modification of the structure of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099564 goslim_synapse GO:0099565 biolink:BiologicalProcess chemical synaptic transmission, postsynaptic The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. go.json postsynaptic process involved in chemical synaptic transmission http://purl.obolibrary.org/obo/GO_0099565 goslim_synapse GO:0099562 biolink:BiologicalProcess maintenance of postsynaptic density structure A process which maintains the organization and the arrangement of proteins in the presynaptic density. go.json http://purl.obolibrary.org/obo/GO_0099562 goslim_synapse GO:0099563 biolink:BiologicalProcess modification of synaptic structure Any process that modifies the structure/morphology of a synapse. go.json synapse remodelling http://purl.obolibrary.org/obo/GO_0099563 goslim_synapse GO:0099560 biolink:BiologicalProcess synaptic membrane adhesion The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. go.json synapse adhesion between pre- and post-synapse http://purl.obolibrary.org/obo/GO_0099560 goslim_synapse GO:0099561 biolink:BiologicalProcess synaptic membrane adhesion to extracellular matrix The binding of a synaptic membrane to the extracellular matrix via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0099561 goslim_synapse GO:0099568 biolink:CellularComponent cytoplasmic region Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0099568 gocheck_do_not_annotate GO:0099569 biolink:CellularComponent presynaptic cytoskeleton The portion of the cytoskeleton contained within the presynapse. go.json http://purl.obolibrary.org/obo/GO_0099569 goslim_synapse GO:0002588 biolink:BiologicalProcess positive regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. go.json activation of antigen processing and presentation of peptide antigen via MHC class II|positive regulation of peptide antigen processing and presentation via MHC class II|stimulation of antigen processing and presentation of peptide antigen via MHC class II|up regulation of antigen processing and presentation of peptide antigen via MHC class II|up-regulation of antigen processing and presentation of peptide antigen via MHC class II|upregulation of antigen processing and presentation of peptide antigen via MHC class II http://purl.obolibrary.org/obo/GO_0002588 GO:0051511 biolink:BiologicalProcess negative regulation of unidimensional cell growth Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis. go.json down regulation of unidimensional cell growth|down-regulation of unidimensional cell growth|downregulation of unidimensional cell growth|inhibition of unidimensional cell growth|negative regulation of cell elongation http://purl.obolibrary.org/obo/GO_0051511 GO:0002589 biolink:BiologicalProcess regulation of antigen processing and presentation of peptide antigen via MHC class I Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. go.json regulation of peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_0002589 GO:0051512 biolink:BiologicalProcess positive regulation of unidimensional cell growth Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis. go.json activation of unidimensional cell growth|positive regulation of cell elongation|stimulation of unidimensional cell growth|up regulation of unidimensional cell growth|up-regulation of unidimensional cell growth|upregulation of unidimensional cell growth http://purl.obolibrary.org/obo/GO_0051512 GO:0051510 biolink:BiologicalProcess regulation of unidimensional cell growth Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis. go.json regulation of cell elongation http://purl.obolibrary.org/obo/GO_0051510 GO:0002584 biolink:BiologicalProcess negative regulation of antigen processing and presentation of peptide antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen. go.json down regulation of antigen processing and presentation of peptide antigen|down-regulation of antigen processing and presentation of peptide antigen|downregulation of antigen processing and presentation of peptide antigen|inhibition of antigen processing and presentation of peptide antigen|negative regulation of peptide antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002584 GO:0051515 biolink:BiologicalProcess positive regulation of monopolar cell growth Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. go.json stimulation of monopolar cell growth|up regulation of monopolar cell growth|up-regulation of monopolar cell growth|upregulation of monopolar cell growth http://purl.obolibrary.org/obo/GO_0051515 GO:0002585 biolink:BiologicalProcess positive regulation of antigen processing and presentation of peptide antigen Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen. go.json activation of antigen processing and presentation of peptide antigen|positive regulation of peptide antigen processing and presentation|stimulation of antigen processing and presentation of peptide antigen|up regulation of antigen processing and presentation of peptide antigen|up-regulation of antigen processing and presentation of peptide antigen|upregulation of antigen processing and presentation of peptide antigen http://purl.obolibrary.org/obo/GO_0002585 GO:0051516 biolink:BiologicalProcess regulation of bipolar cell growth Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. go.json http://purl.obolibrary.org/obo/GO_0051516 GO:0002586 biolink:BiologicalProcess regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. go.json regulation of peptide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002586 GO:0051513 biolink:BiologicalProcess regulation of monopolar cell growth Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. go.json http://purl.obolibrary.org/obo/GO_0051513 GO:0002587 biolink:BiologicalProcess negative regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. go.json down regulation of antigen processing and presentation of peptide antigen via MHC class II|down-regulation of antigen processing and presentation of peptide antigen via MHC class II|downregulation of antigen processing and presentation of peptide antigen via MHC class II|inhibition of antigen processing and presentation of peptide antigen via MHC class II|negative regulation of peptide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002587 GO:0051514 biolink:BiologicalProcess negative regulation of monopolar cell growth Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. go.json down regulation of monopolar cell growth|down-regulation of monopolar cell growth|downregulation of monopolar cell growth|inhibition of monopolar cell growth http://purl.obolibrary.org/obo/GO_0051514 GO:0051519 biolink:BiologicalProcess activation of bipolar cell growth Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell. go.json http://purl.obolibrary.org/obo/GO_0051519 GO:0002580 biolink:BiologicalProcess regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. go.json regulation of peptide or polysaccharide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002580 GO:0002581 biolink:BiologicalProcess negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. go.json down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002581 GO:0051517 biolink:BiologicalProcess negative regulation of bipolar cell growth Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. go.json down regulation of bipolar cell growth|down-regulation of bipolar cell growth|downregulation of bipolar cell growth|inhibition of bipolar cell growth http://purl.obolibrary.org/obo/GO_0051517 GO:0002582 biolink:BiologicalProcess positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. go.json activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II|stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II http://purl.obolibrary.org/obo/GO_0002582 GO:0002583 biolink:BiologicalProcess regulation of antigen processing and presentation of peptide antigen Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. go.json regulation of peptide antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002583 GO:0051518 biolink:BiologicalProcess positive regulation of bipolar cell growth Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. go.json stimulation of bipolar cell growth|up regulation of bipolar cell growth|up-regulation of bipolar cell growth|upregulation of bipolar cell growth http://purl.obolibrary.org/obo/GO_0051518 GO:1905920 biolink:BiologicalProcess positive regulation of CoA-transferase activity Any process that activates or increases the frequency, rate or extent of CoA-transferase activity. go.json activation of CoA-transferase activity|up regulation of CoA-transferase activity|up-regulation of CoA-transferase activity|upregulation of CoA-transferase activity http://purl.obolibrary.org/obo/GO_1905920 gocheck_do_not_annotate GO:1905921 biolink:BiologicalProcess regulation of acetylcholine biosynthetic process Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process. go.json regulation of acetylcholine anabolism|regulation of acetylcholine biosynthesis|regulation of acetylcholine formation|regulation of acetylcholine synthesis http://purl.obolibrary.org/obo/GO_1905921 GO:1905922 biolink:BiologicalProcess negative regulation of acetylcholine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process. go.json down regulation of acetylcholine anabolism|down regulation of acetylcholine biosynthesis|down regulation of acetylcholine biosynthetic process|down regulation of acetylcholine formation|down regulation of acetylcholine synthesis|down-regulation of acetylcholine anabolism|down-regulation of acetylcholine biosynthesis|down-regulation of acetylcholine biosynthetic process|down-regulation of acetylcholine formation|down-regulation of acetylcholine synthesis|downregulation of acetylcholine anabolism|downregulation of acetylcholine biosynthesis|downregulation of acetylcholine biosynthetic process|downregulation of acetylcholine formation|downregulation of acetylcholine synthesis|inhibition of acetylcholine anabolism|inhibition of acetylcholine biosynthesis|inhibition of acetylcholine biosynthetic process|inhibition of acetylcholine formation|inhibition of acetylcholine synthesis|negative regulation of acetylcholine anabolism|negative regulation of acetylcholine biosynthesis|negative regulation of acetylcholine formation|negative regulation of acetylcholine synthesis http://purl.obolibrary.org/obo/GO_1905922 GO:1905923 biolink:BiologicalProcess positive regulation of acetylcholine biosynthetic process Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process. go.json activation of acetylcholine anabolism|activation of acetylcholine biosynthesis|activation of acetylcholine biosynthetic process|activation of acetylcholine formation|activation of acetylcholine synthesis|positive regulation of acetylcholine anabolism|positive regulation of acetylcholine biosynthesis|positive regulation of acetylcholine formation|positive regulation of acetylcholine synthesis|up regulation of acetylcholine anabolism|up regulation of acetylcholine biosynthesis|up regulation of acetylcholine biosynthetic process|up regulation of acetylcholine formation|up regulation of acetylcholine synthesis|up-regulation of acetylcholine anabolism|up-regulation of acetylcholine biosynthesis|up-regulation of acetylcholine biosynthetic process|up-regulation of acetylcholine formation|up-regulation of acetylcholine synthesis|upregulation of acetylcholine anabolism|upregulation of acetylcholine biosynthesis|upregulation of acetylcholine biosynthetic process|upregulation of acetylcholine formation|upregulation of acetylcholine synthesis http://purl.obolibrary.org/obo/GO_1905923 GO:1905924 biolink:BiologicalProcess obsolete regulation of invadopodium assembly OBSOLETE. Any process that modulates the frequency, rate or extent of invadopodium assembly. go.json regulation of invadopodium formation True http://purl.obolibrary.org/obo/GO_1905924 GO:1905925 biolink:BiologicalProcess obsolete negative regulation of invadopodium assembly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium assembly. go.json down regulation of invadopodium assembly|down regulation of invadopodium formation|down-regulation of invadopodium assembly|down-regulation of invadopodium formation|downregulation of invadopodium assembly|downregulation of invadopodium formation|inhibition of invadopodium assembly|inhibition of invadopodium formation|negative regulation of invadopodium formation True http://purl.obolibrary.org/obo/GO_1905925 GO:1905926 biolink:BiologicalProcess obsolete positive regulation of invadopodium assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of invadopodium assembly. go.json activation of invadopodium assembly|activation of invadopodium formation|positive regulation of invadopodium formation|up regulation of invadopodium assembly|up regulation of invadopodium formation|up-regulation of invadopodium assembly|up-regulation of invadopodium formation|upregulation of invadopodium assembly|upregulation of invadopodium formation True http://purl.obolibrary.org/obo/GO_1905926 GO:1905927 biolink:BiologicalProcess obsolete regulation of invadopodium disassembly OBSOLETE. Any process that modulates the frequency, rate or extent of invadopodium disassembly. go.json True http://purl.obolibrary.org/obo/GO_1905927 GO:1905928 biolink:BiologicalProcess obsolete negative regulation of invadopodium disassembly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium disassembly. go.json down regulation of invadopodium disassembly|down-regulation of invadopodium disassembly|downregulation of invadopodium disassembly|inhibition of invadopodium disassembly True http://purl.obolibrary.org/obo/GO_1905928 GO:1905929 biolink:BiologicalProcess obsolete positive regulation of invadopodium disassembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of invadopodium disassembly. go.json activation of invadopodium disassembly|up regulation of invadopodium disassembly|up-regulation of invadopodium disassembly|upregulation of invadopodium disassembly True http://purl.obolibrary.org/obo/GO_1905929 GO:0002599 biolink:BiologicalProcess negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. go.json down regulation of antigen processing and presentation of lipid antigen via MHC class Ib|down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib|downregulation of antigen processing and presentation of lipid antigen via MHC class Ib|inhibition of antigen processing and presentation of lipid antigen via MHC class Ib|negative regulation of lipid antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002599 GO:0051522 biolink:BiologicalProcess activation of monopolar cell growth Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell. go.json http://purl.obolibrary.org/obo/GO_0051522 GO:0051523 biolink:BiologicalProcess cell growth mode switching, monopolar to bipolar The process in which a cell switches from monopolar cell growth to bipolar cell growth. go.json NETO|new end take off http://purl.obolibrary.org/obo/GO_0051523 GO:0051520 biolink:BiologicalProcess termination of bipolar cell growth Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell. go.json http://purl.obolibrary.org/obo/GO_0051520 GO:0051521 biolink:BiologicalProcess termination of monopolar cell growth Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell. go.json http://purl.obolibrary.org/obo/GO_0051521 GO:0051526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051526 GO:0002595 biolink:BiologicalProcess regulation of antigen processing and presentation of peptide antigen via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. go.json regulation of peptide antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002595 GO:0002596 biolink:BiologicalProcess negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. go.json down regulation of antigen processing and presentation of peptide antigen via MHC class Ib|down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib|downregulation of antigen processing and presentation of peptide antigen via MHC class Ib|inhibition of antigen processing and presentation of peptide antigen via MHC class Ib|negative regulation of peptide antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002596 GO:0051527 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051527 GO:0002597 biolink:BiologicalProcess positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. go.json activation of antigen processing and presentation of peptide antigen via MHC class Ib|positive regulation of peptide antigen processing and presentation via MHC class Ib|stimulation of antigen processing and presentation of peptide antigen via MHC class Ib|up regulation of antigen processing and presentation of peptide antigen via MHC class Ib|up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib|upregulation of antigen processing and presentation of peptide antigen via MHC class Ib http://purl.obolibrary.org/obo/GO_0002597 GO:0051524 biolink:BiologicalProcess cell growth mode switching, bipolar to monopolar The process in which a cell switches from bipolar cell growth to monopolar cell growth. go.json http://purl.obolibrary.org/obo/GO_0051524 GO:0051525 biolink:MolecularActivity NFAT protein binding Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. go.json NFAT binding|NFAT1 protein binding|NFAT2 protein binding|NFAT3 protein binding|NFAT4 protein binding|NFAT5 protein binding|NFATc binding|NFATc1 binding|NFATc2 binding|NFATc3 binding|NFATc4 binding|NFATp binding|NFATx binding|non-calcium-regulated NFAT protein binding|nuclear factor of activated T cell protein binding http://purl.obolibrary.org/obo/GO_0051525 GO:0002598 biolink:BiologicalProcess regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. go.json regulation of lipid antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002598 GO:0002591 biolink:BiologicalProcess positive regulation of antigen processing and presentation of peptide antigen via MHC class I Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. go.json activation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of peptide antigen processing and presentation via MHC class I|stimulation of antigen processing and presentation of peptide antigen via MHC class I|up regulation of antigen processing and presentation of peptide antigen via MHC class I|up-regulation of antigen processing and presentation of peptide antigen via MHC class I|upregulation of antigen processing and presentation of peptide antigen via MHC class I http://purl.obolibrary.org/obo/GO_0002591 GO:0002592 biolink:BiologicalProcess regulation of antigen processing and presentation via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. go.json http://purl.obolibrary.org/obo/GO_0002592 GO:0002593 biolink:BiologicalProcess negative regulation of antigen processing and presentation via MHC class Ib Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. go.json down regulation of antigen processing and presentation via MHC class Ib|down-regulation of antigen processing and presentation via MHC class Ib|downregulation of antigen processing and presentation via MHC class Ib|inhibition of antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002593 GO:0051528 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051528 GO:0002594 biolink:BiologicalProcess positive regulation of antigen processing and presentation via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. go.json activation of antigen processing and presentation via MHC class Ib|stimulation of antigen processing and presentation via MHC class Ib|up regulation of antigen processing and presentation via MHC class Ib|up-regulation of antigen processing and presentation via MHC class Ib|upregulation of antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002594 GO:0051529 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051529 GO:0002590 biolink:BiologicalProcess negative regulation of antigen processing and presentation of peptide antigen via MHC class I Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. go.json down regulation of antigen processing and presentation of peptide antigen via MHC class I|down-regulation of antigen processing and presentation of peptide antigen via MHC class I|downregulation of antigen processing and presentation of peptide antigen via MHC class I|inhibition of antigen processing and presentation of peptide antigen via MHC class I|negative regulation of peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_0002590 GO:1905930 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. go.json regulation of VSMC differentiation involved in phenotypic dimorphism|regulation of VSMC differentiation involved in phenotypic switching|regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|regulation of vascular smooth muscle cell differentiation involved in phenotypic switching http://purl.obolibrary.org/obo/GO_1905930 GO:1905931 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. go.json down regulation of VSMC differentiation involved in phenotypic dimorphism|down regulation of VSMC differentiation involved in phenotypic switching|down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|down regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|down regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|down-regulation of VSMC differentiation involved in phenotypic dimorphism|down-regulation of VSMC differentiation involved in phenotypic switching|down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|down-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|down-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|downregulation of VSMC differentiation involved in phenotypic dimorphism|downregulation of VSMC differentiation involved in phenotypic switching|downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|downregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|downregulation of vascular smooth muscle cell differentiation involved in phenotypic switching|inhibition of VSMC differentiation involved in phenotypic dimorphism|inhibition of VSMC differentiation involved in phenotypic switching|inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic switching|inhibition of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|inhibition of vascular smooth muscle cell differentiation involved in phenotypic switching|negative regulation of VSMC differentiation involved in phenotypic dimorphism|negative regulation of VSMC differentiation involved in phenotypic switching|negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching http://purl.obolibrary.org/obo/GO_1905931 GO:1905932 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. go.json activation of VSMC differentiation involved in phenotypic dimorphism|activation of VSMC differentiation involved in phenotypic switching|activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|activation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|activation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|activation of vascular smooth muscle cell differentiation involved in phenotypic switching|positive regulation of VSMC differentiation involved in phenotypic dimorphism|positive regulation of VSMC differentiation involved in phenotypic switching|positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|up regulation of VSMC differentiation involved in phenotypic dimorphism|up regulation of VSMC differentiation involved in phenotypic switching|up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|up regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|up regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|up-regulation of VSMC differentiation involved in phenotypic dimorphism|up-regulation of VSMC differentiation involved in phenotypic switching|up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|up-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|up-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|upregulation of VSMC differentiation involved in phenotypic dimorphism|upregulation of VSMC differentiation involved in phenotypic switching|upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|upregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism|upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching http://purl.obolibrary.org/obo/GO_1905932 GO:1905933 biolink:BiologicalProcess regulation of cell fate determination Any process that modulates the frequency, rate or extent of cell fate determination. go.json http://purl.obolibrary.org/obo/GO_1905933 GO:1905934 biolink:BiologicalProcess negative regulation of cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination. go.json down regulation of cell fate determination|down-regulation of cell fate determination|downregulation of cell fate determination|inhibition of cell fate determination http://purl.obolibrary.org/obo/GO_1905934 GO:1905935 biolink:BiologicalProcess positive regulation of cell fate determination Any process that activates or increases the frequency, rate or extent of cell fate determination. go.json activation of cell fate determination|up regulation of cell fate determination|up-regulation of cell fate determination|upregulation of cell fate determination http://purl.obolibrary.org/obo/GO_1905935 GO:1905936 biolink:BiologicalProcess regulation of germ cell proliferation Any process that modulates the frequency, rate or extent of germ cell proliferation. go.json http://purl.obolibrary.org/obo/GO_1905936 GO:1905937 biolink:BiologicalProcess negative regulation of germ cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. go.json down regulation of germ cell proliferation|down-regulation of germ cell proliferation|downregulation of germ cell proliferation|inhibition of germ cell proliferation http://purl.obolibrary.org/obo/GO_1905937 GO:1905938 biolink:BiologicalProcess positive regulation of germ cell proliferation Any process that activates or increases the frequency, rate or extent of germ cell proliferation. go.json activation of germ cell proliferation|up regulation of germ cell proliferation|up-regulation of germ cell proliferation|upregulation of germ cell proliferation http://purl.obolibrary.org/obo/GO_1905938 GO:1905939 biolink:BiologicalProcess regulation of gonad development Any process that modulates the frequency, rate or extent of gonad development. go.json regulation of gonadogenesis http://purl.obolibrary.org/obo/GO_1905939 GO:0051533 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051533 GO:0002566 biolink:BiologicalProcess somatic diversification of immune receptors via somatic mutation The process in which immune receptor genes are diversified through somatic mutation. go.json http://purl.obolibrary.org/obo/GO_0002566 GO:0075501 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075501 GO:0051534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051534 GO:0002567 biolink:BiologicalProcess somatic diversification of FREP-based immune receptors The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails. go.json http://purl.obolibrary.org/obo/GO_0002567 GO:0075502 biolink:BiologicalProcess endosome membrane permeabilization involved in viral entry into host cell Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm. go.json viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane|viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization http://purl.obolibrary.org/obo/GO_0075502 GO:0002568 biolink:BiologicalProcess somatic diversification of T cell receptor genes The somatic process that results in the generation of sequence diversity of T cell receptor genes. go.json somatic diversification of TCR genes http://purl.obolibrary.org/obo/GO_0002568 GO:0051531 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051531 GO:0051532 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051532 GO:0075503 biolink:BiologicalProcess fusion of virus membrane with host macropinosome membrane Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm. go.json viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane|viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane http://purl.obolibrary.org/obo/GO_0075503 GO:0002569 biolink:BiologicalProcess somatic diversification of immune receptors by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. go.json http://purl.obolibrary.org/obo/GO_0002569 GO:0002562 biolink:BiologicalProcess somatic diversification of immune receptors via germline recombination within a single locus The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. go.json http://purl.obolibrary.org/obo/GO_0002562 GO:0051537 biolink:MolecularActivity 2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. go.json 2 Fe 2 S cluster binding|2 iron, 2 sulphur cluster binding|2Fe-2S cluster binding|diiron disulfide cluster binding|diiron disulphide cluster binding|iron-sulfur cluster 2Fe-2S binding|iron-sulphur cluster 2Fe-2S binding http://purl.obolibrary.org/obo/GO_0051537 GO:0075504 biolink:BiologicalProcess macropinosomal membrane permeabilization involved in viral entry into host cell Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm. go.json viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization http://purl.obolibrary.org/obo/GO_0075504 GO:0051538 biolink:MolecularActivity 3 iron, 4 sulfur cluster binding Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. go.json 3 Fe 4 S cluster binding|3 iron, 4 sulphur cluster binding|3Fe-4S cluster binding|iron-sulfur cluster 3Fe-4S binding|iron-sulphur cluster 3Fe-4S binding|triiron tetrasulfide cluster binding|triiron tetrasulphide cluster binding http://purl.obolibrary.org/obo/GO_0051538 GO:0002563 biolink:BiologicalProcess somatic diversification of immune receptors via alternate splicing The process in which immune receptor genes are diversified through alternate splicing. go.json http://purl.obolibrary.org/obo/GO_0002563 GO:0075505 biolink:BiologicalProcess entry of intact viral capsid into host nucleus through nuclear pore complex Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC). go.json http://purl.obolibrary.org/obo/GO_0075505 GO:0051535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051535 GO:0075506 biolink:BiologicalProcess entry of viral genome into host nucleus through nuclear pore complex via importin Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery. go.json entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex http://purl.obolibrary.org/obo/GO_0075506 GO:0002564 biolink:BiologicalProcess alternate splicing of immunoglobulin genes The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons. go.json alternate splicing of antibody genes http://purl.obolibrary.org/obo/GO_0002564 GO:0051536 biolink:MolecularActivity iron-sulfur cluster binding Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. go.json Fe/S binding|iron sulfur cluster binding|iron sulphur cluster binding|iron-sulphur cluster binding http://purl.obolibrary.org/obo/GO_0051536 goslim_metagenomics GO:0002565 biolink:BiologicalProcess somatic diversification of immune receptors via gene conversion The process in which immune receptor genes are diversified through gene conversion. go.json http://purl.obolibrary.org/obo/GO_0002565 GO:0075507 biolink:BiologicalProcess entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm. go.json http://purl.obolibrary.org/obo/GO_0075507 GO:0075508 biolink:BiologicalProcess entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm. go.json entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm http://purl.obolibrary.org/obo/GO_0075508 GO:0075509 biolink:BiologicalProcess endocytosis involved in viral entry into host cell Any endocytosis that is involved in the uptake of a virus into a host cell. VZ:977 go.json viral entry into host cell via endocytosis|viral penetration via endocytosis followed by endosome disruption|virus endocytosis by host http://purl.obolibrary.org/obo/GO_0075509 GO:0051539 biolink:MolecularActivity 4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. go.json 4 Fe 4 S cluster binding|4 iron, 4 sulphur cluster binding|4Fe-4S cluster binding|iron-sulfur cluster 4Fe-4S binding|iron-sulphur cluster 4Fe-4S binding|tetrairon tetrasulfide cluster binding|tetrairon tetrasulphide cluster binding http://purl.obolibrary.org/obo/GO_0051539 GO:0002560 biolink:BiologicalProcess basophil mediated immunity Any process involved in the carrying out of an immune response by a basophil. go.json http://purl.obolibrary.org/obo/GO_0002560 GO:0002561 biolink:BiologicalProcess basophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil. go.json http://purl.obolibrary.org/obo/GO_0002561 GO:1905940 biolink:BiologicalProcess negative regulation of gonad development Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. go.json down regulation of gonad development|down regulation of gonadogenesis|down-regulation of gonad development|down-regulation of gonadogenesis|downregulation of gonad development|downregulation of gonadogenesis|inhibition of gonad development|inhibition of gonadogenesis|negative regulation of gonadogenesis http://purl.obolibrary.org/obo/GO_1905940 GO:1905941 biolink:BiologicalProcess positive regulation of gonad development Any process that activates or increases the frequency, rate or extent of gonad development. go.json activation of gonad development|activation of gonadogenesis|positive regulation of gonadogenesis|up regulation of gonad development|up regulation of gonadogenesis|up-regulation of gonad development|up-regulation of gonadogenesis|upregulation of gonad development|upregulation of gonadogenesis http://purl.obolibrary.org/obo/GO_1905941 GO:1905942 biolink:BiologicalProcess regulation of formation of growth cone in injured axon Any process that modulates the frequency, rate or extent of formation of growth cone in injured axon. go.json http://purl.obolibrary.org/obo/GO_1905942 GO:1905943 biolink:BiologicalProcess negative regulation of formation of growth cone in injured axon Any process that stops, prevents or reduces the frequency, rate or extent of formation of growth cone in injured axon. go.json down regulation of formation of growth cone in injured axon|down-regulation of formation of growth cone in injured axon|downregulation of formation of growth cone in injured axon|inhibition of formation of growth cone in injured axon http://purl.obolibrary.org/obo/GO_1905943 GO:1905944 biolink:BiologicalProcess positive regulation of formation of growth cone in injured axon Any process that activates or increases the frequency, rate or extent of formation of growth cone in injured axon. go.json activation of formation of growth cone in injured axon|up regulation of formation of growth cone in injured axon|up-regulation of formation of growth cone in injured axon|upregulation of formation of growth cone in injured axon http://purl.obolibrary.org/obo/GO_1905944 GO:1905945 biolink:BiologicalProcess regulation of response to calcium ion Any process that modulates the frequency, rate or extent of response to calcium ion. go.json regulation of response to Ca2+ ion http://purl.obolibrary.org/obo/GO_1905945 GO:1905946 biolink:BiologicalProcess negative regulation of response to calcium ion Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion. go.json down regulation of response to Ca2+ ion|down regulation of response to calcium ion|down-regulation of response to Ca2+ ion|down-regulation of response to calcium ion|downregulation of response to Ca2+ ion|downregulation of response to calcium ion|inhibition of response to Ca2+ ion|inhibition of response to calcium ion|negative regulation of response to Ca2+ ion http://purl.obolibrary.org/obo/GO_1905946 GO:1905947 biolink:BiologicalProcess positive regulation of response to calcium ion Any process that activates or increases the frequency, rate or extent of response to calcium ion. go.json activation of response to Ca2+ ion|activation of response to calcium ion|positive regulation of response to Ca2+ ion|up regulation of response to Ca2+ ion|up regulation of response to calcium ion|up-regulation of response to Ca2+ ion|up-regulation of response to calcium ion|upregulation of response to Ca2+ ion|upregulation of response to calcium ion http://purl.obolibrary.org/obo/GO_1905947 GO:1905948 biolink:MolecularActivity ABC-type 3',5'-cyclic GMP transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out). go.json 3',5'-cyclic GMP transmembrane-transporting ATPase activity|ATP-dependent 3',5'-cyclic GMP transmembrane transporter activity|ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity|ATPase-coupled cGMP transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1905948 GO:1905949 biolink:BiologicalProcess negative regulation of calcium ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane. go.json down regulation of calcium ion import across plasma membrane|down-regulation of calcium ion import across plasma membrane|downregulation of calcium ion import across plasma membrane|inhibition of calcium ion import across plasma membrane http://purl.obolibrary.org/obo/GO_1905949 GO:0051530 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051530 GO:0051544 biolink:BiologicalProcess positive regulation of elastin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. go.json activation of elastin biosynthetic process|stimulation of elastin biosynthetic process|up regulation of elastin biosynthetic process|up-regulation of elastin biosynthetic process|upregulation of elastin biosynthetic process http://purl.obolibrary.org/obo/GO_0051544 GO:0002577 biolink:BiologicalProcess regulation of antigen processing and presentation Any process that modulates the frequency, rate, or extent of antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002577 GO:0002578 biolink:BiologicalProcess negative regulation of antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. go.json down regulation of antigen processing and presentation|down-regulation of antigen processing and presentation|downregulation of antigen processing and presentation|inhibition of antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002578 GO:0051545 biolink:BiologicalProcess negative regulation of elastin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. go.json down regulation of elastin biosynthetic process|down-regulation of elastin biosynthetic process|downregulation of elastin biosynthetic process|inhibition of elastin biosynthetic process http://purl.obolibrary.org/obo/GO_0051545 GO:0002579 biolink:BiologicalProcess positive regulation of antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. go.json activation of antigen processing and presentation|stimulation of antigen processing and presentation|up regulation of antigen processing and presentation|up-regulation of antigen processing and presentation|upregulation of antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002579 GO:0051542 biolink:BiologicalProcess elastin biosynthetic process The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries. go.json http://purl.obolibrary.org/obo/GO_0051542 GO:0051543 biolink:BiologicalProcess regulation of elastin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. go.json http://purl.obolibrary.org/obo/GO_0051543 GO:0051548 biolink:BiologicalProcess negative regulation of keratinocyte migration Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration. go.json down regulation of keratinocyte migration|down-regulation of keratinocyte migration|downregulation of keratinocyte migration|inhibition of keratinocyte migration http://purl.obolibrary.org/obo/GO_0051548 GO:0002573 biolink:BiologicalProcess myeloid leukocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. go.json myeloid leucocyte differentiation http://purl.obolibrary.org/obo/GO_0002573 GO:0051549 biolink:BiologicalProcess positive regulation of keratinocyte migration Any process that activates or increases the frequency, rate or extent of keratinocyte migration. go.json activation of keratinocyte migration|stimulation of keratinocyte migration|up regulation of keratinocyte migration|up-regulation of keratinocyte migration|upregulation of keratinocyte migration http://purl.obolibrary.org/obo/GO_0051549 GO:0002574 biolink:BiologicalProcess thrombocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis. go.json http://purl.obolibrary.org/obo/GO_0002574 GO:0002575 biolink:BiologicalProcess basophil chemotaxis The movement of a basophil in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002575 GO:0051546 biolink:BiologicalProcess keratinocyte migration The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another. go.json http://purl.obolibrary.org/obo/GO_0051546 GO:0051547 biolink:BiologicalProcess regulation of keratinocyte migration Any process that modulates the frequency, rate or extent of keratinocyte migration. go.json http://purl.obolibrary.org/obo/GO_0051547 GO:0002576 biolink:BiologicalProcess platelet degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. go.json platelet exocytosis http://purl.obolibrary.org/obo/GO_0002576 GO:0002570 biolink:BiologicalProcess somatic diversification of immunoglobulin genes by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. go.json somatic diversification of antibody genes by N region addition http://purl.obolibrary.org/obo/GO_0002570 GO:0002571 biolink:BiologicalProcess somatic diversification of T cell receptor genes by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene. go.json somatic diversification of TCR genes by N region addition http://purl.obolibrary.org/obo/GO_0002571 GO:0002572 biolink:BiologicalProcess pro-T cell differentiation The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. go.json pro-T lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002572 GO:1905960 biolink:BiologicalProcess response to differentiation-inducing factor 2 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus. go.json response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one|response to DIF-2|response to DIF2 http://purl.obolibrary.org/obo/GO_1905960 GO:1905950 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905950 GO:1905951 biolink:BiologicalProcess mitochondrion DNA recombination Any DNA recombination that takes place in mitochondrion. go.json DNA recombination in mitochondria http://purl.obolibrary.org/obo/GO_1905951 GO:1905952 biolink:BiologicalProcess regulation of lipid localization Any process that modulates the frequency, rate or extent of lipid localization. go.json regulation of lipid localisation http://purl.obolibrary.org/obo/GO_1905952 GO:1905953 biolink:BiologicalProcess negative regulation of lipid localization Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. go.json down regulation of lipid localisation|down regulation of lipid localization|down-regulation of lipid localisation|down-regulation of lipid localization|downregulation of lipid localisation|downregulation of lipid localization|inhibition of lipid localisation|inhibition of lipid localization|negative regulation of lipid localisation http://purl.obolibrary.org/obo/GO_1905953 GO:1905954 biolink:BiologicalProcess positive regulation of lipid localization Any process that activates or increases the frequency, rate or extent of lipid localization. go.json activation of lipid localisation|activation of lipid localization|positive regulation of lipid localisation|up regulation of lipid localisation|up regulation of lipid localization|up-regulation of lipid localisation|up-regulation of lipid localization|upregulation of lipid localisation|upregulation of lipid localization http://purl.obolibrary.org/obo/GO_1905954 GO:1905955 biolink:BiologicalProcess negative regulation of endothelial tube morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. go.json down regulation of endothelial tube morphogenesis|down-regulation of endothelial tube morphogenesis|downregulation of endothelial tube morphogenesis|inhibition of endothelial tube morphogenesis http://purl.obolibrary.org/obo/GO_1905955 GO:1905956 biolink:BiologicalProcess positive regulation of endothelial tube morphogenesis Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. go.json activation of endothelial tube morphogenesis|up regulation of endothelial tube morphogenesis|up-regulation of endothelial tube morphogenesis|upregulation of endothelial tube morphogenesis http://purl.obolibrary.org/obo/GO_1905956 GO:1905957 biolink:BiologicalProcess regulation of cellular response to alcohol Any process that modulates the frequency, rate or extent of cellular response to alcohol. go.json http://purl.obolibrary.org/obo/GO_1905957 GO:1905958 biolink:BiologicalProcess negative regulation of cellular response to alcohol Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alcohol. go.json down regulation of cellular response to alcohol|down-regulation of cellular response to alcohol|downregulation of cellular response to alcohol|inhibition of cellular response to alcohol http://purl.obolibrary.org/obo/GO_1905958 GO:1905959 biolink:BiologicalProcess positive regulation of cellular response to alcohol Any process that activates or increases the frequency, rate or extent of cellular response to alcohol. go.json activation of cellular response to alcohol|up regulation of cellular response to alcohol|up-regulation of cellular response to alcohol|upregulation of cellular response to alcohol http://purl.obolibrary.org/obo/GO_1905959 GO:0051540 biolink:MolecularActivity metal cluster binding Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. go.json http://purl.obolibrary.org/obo/GO_0051540 goslim_pir GO:0051541 biolink:BiologicalProcess elastin metabolic process The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. go.json elastin metabolism http://purl.obolibrary.org/obo/GO_0051541 GO:0051555 biolink:BiologicalProcess flavonol biosynthetic process The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. MetaCyc:PWY-3101 go.json http://purl.obolibrary.org/obo/GO_0051555 GO:0075522 biolink:BiologicalProcess IRES-dependent viral translational initiation Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. VZ:867 go.json http://purl.obolibrary.org/obo/GO_0075522 GO:0002544 biolink:BiologicalProcess chronic inflammatory response Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. go.json http://purl.obolibrary.org/obo/GO_0002544 GO:0075523 biolink:BiologicalProcess viral translational frameshifting A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins. VZ:860 go.json ribosomal frameshifting involved in viral translation http://purl.obolibrary.org/obo/GO_0075523 GO:0002545 biolink:BiologicalProcess chronic inflammatory response to non-antigenic stimulus A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma. go.json http://purl.obolibrary.org/obo/GO_0002545 GO:0051556 biolink:BiologicalProcess leucoanthocyanidin metabolic process The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids. MetaCyc:PWY1F-823 go.json leucoanthocyanidin metabolism http://purl.obolibrary.org/obo/GO_0051556 GO:0002546 biolink:BiologicalProcess negative regulation of tissue kallikrein-kinin cascade Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade. go.json down regulation of tissue kallikrein-kinin cascade|down-regulation of tissue kallikrein-kinin cascade|downregulation of tissue kallikrein-kinin cascade|inhibition of tissue kallikrein-kinin cascade|negative regulation of glandular kallikrein-kinin cascade http://purl.obolibrary.org/obo/GO_0002546 GO:0075524 biolink:BiologicalProcess ribosomal skipping A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue. VZ:914 go.json http://purl.obolibrary.org/obo/GO_0075524 GO:0051553 biolink:BiologicalProcess flavone biosynthetic process The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). go.json 2-phenyl-4H-1-benzopyran-4-one biosynthesis|2-phenyl-4H-1-benzopyran-4-one biosynthetic process|2-phenylchromone biosynthesis|2-phenylchromone biosynthetic process http://purl.obolibrary.org/obo/GO_0051553 GO:0075525 biolink:BiologicalProcess viral translational termination-reinitiation A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. VZ:858 go.json termination reinitiation involved in viral translation|viral translation involving termination re-initiation|viral translation involving termination-reinitiation|viral translation involving translational stop-start http://purl.obolibrary.org/obo/GO_0075525 GO:0051554 biolink:BiologicalProcess flavonol metabolic process The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. go.json flavonol metabolism http://purl.obolibrary.org/obo/GO_0051554 GO:0002547 biolink:BiologicalProcess positive regulation of tissue kallikrein-kinin cascade Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade. go.json activation of tissue kallikrein-kinin cascade|positive regulation of glandular kallikrein-kinin cascade|stimulation of tissue kallikrein-kinin cascade|up regulation of tissue kallikrein-kinin cascade|up-regulation of tissue kallikrein-kinin cascade|upregulation of tissue kallikrein-kinin cascade http://purl.obolibrary.org/obo/GO_0002547 GO:0002540 biolink:BiologicalProcess leukotriene production involved in inflammatory response The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json leukotriene production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002540 GO:0075526 biolink:BiologicalProcess cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs. VZ:839 go.json cap snatching involved in viral mRNA transcription http://purl.obolibrary.org/obo/GO_0075526 GO:0051559 biolink:BiologicalProcess phlobaphene biosynthetic process The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. go.json http://purl.obolibrary.org/obo/GO_0051559 GO:0075527 biolink:BiologicalProcess viral RNA editing The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon. VZ:857 go.json RNA editing involved in viral mRNA transcription http://purl.obolibrary.org/obo/GO_0075527 GO:0002541 biolink:BiologicalProcess activation of plasma proteins involved in acute inflammatory response Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0002541 GO:0075528 biolink:BiologicalProcess perturbation by virus of host immune response A process in which a virus effects a change in the host immune response. go.json regulation by virus of host immune system process http://purl.obolibrary.org/obo/GO_0075528 GO:0051557 biolink:BiologicalProcess leucoanthocyanidin biosynthetic process The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids. go.json http://purl.obolibrary.org/obo/GO_0051557 GO:0002542 biolink:BiologicalProcess Factor XII activation Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. go.json Hageman factor activation http://purl.obolibrary.org/obo/GO_0002542 GO:0075529 biolink:BiologicalProcess establishment of latency as a circular episome A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure. go.json establishment of circular plasmid latency|establishment of latency as a circular plasmid http://purl.obolibrary.org/obo/GO_0075529 GO:0002543 biolink:BiologicalProcess activation of blood coagulation via clotting cascade Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot. go.json activation of clotting cascade http://purl.obolibrary.org/obo/GO_0002543 GO:0051558 biolink:BiologicalProcess phlobaphene metabolic process The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. go.json phlobaphene metabolism http://purl.obolibrary.org/obo/GO_0051558 GO:1905961 biolink:CellularComponent protein-cysteine S-palmitoyltransferase complex A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity. go.json Palmitoyltransferase ERF2-SHR5 complex|Palmitoyltransferase ERF2/SHR5 complex http://purl.obolibrary.org/obo/GO_1905961 GO:1905962 biolink:BiologicalProcess glutamatergic neuron differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron. go.json http://purl.obolibrary.org/obo/GO_1905962 GO:1905963 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905963 GO:1905964 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905964 GO:1905965 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905965 GO:0051551 biolink:BiologicalProcess aurone biosynthetic process The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments. go.json benzalcoumaran-3-one biosynthesis|benzalcoumaran-3-one biosynthetic process http://purl.obolibrary.org/obo/GO_0051551 GO:0002548 biolink:BiologicalProcess monocyte chemotaxis The movement of a monocyte in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002548 GO:0051552 biolink:BiologicalProcess flavone metabolic process The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). go.json 2-phenyl-4H-1-benzopyran-4-one metabolic process|2-phenyl-4H-1-benzopyran-4-one metabolism|2-phenylchromone metabolic process|2-phenylchromone metabolism|flavone metabolism http://purl.obolibrary.org/obo/GO_0051552 GO:0002549 biolink:BiologicalProcess negative regulation of plasma kallikrein-kinin cascade Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade. go.json down regulation of plasma kallikrein-kinin cascade|down-regulation of plasma kallikrein-kinin cascade|downregulation of plasma kallikrein-kinin cascade|inhibition of plasma kallikrein-kinin cascade http://purl.obolibrary.org/obo/GO_0002549 GO:0075520 biolink:BiologicalProcess actin-dependent intracellular transport of virus The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions. VZ:991 go.json actin-dependent intracellular transport of viral material http://purl.obolibrary.org/obo/GO_0075520 GO:0051550 biolink:BiologicalProcess aurone metabolic process The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides. go.json aurone metabolism|benzalcoumaran-3-one metabolic process|benzalcoumaran-3-one metabolism http://purl.obolibrary.org/obo/GO_0051550 GO:0075521 biolink:BiologicalProcess microtubule-dependent intracellular transport of viral material towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules. VZ:983 go.json microtubule-dependent intracellular transport of viral material to nucleus http://purl.obolibrary.org/obo/GO_0075521 GO:0075511 biolink:BiologicalProcess macropinosome lysis involved in viral entry into host cell Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0075511 GO:0099500 biolink:BiologicalProcess vesicle fusion to plasma membrane Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. go.json http://purl.obolibrary.org/obo/GO_0099500 GO:0051566 biolink:MolecularActivity anthocyanidin-3-glucoside rhamnosyltransferase activity Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP. go.json 3RT activity|anthocyanidin 3-glucoside-rhamnosyltransferase activity http://purl.obolibrary.org/obo/GO_0051566 GO:0002555 biolink:BiologicalProcess histamine secretion by platelet The regulated release of histamine by a platelet or group of platelets. go.json http://purl.obolibrary.org/obo/GO_0002555 GO:0075512 biolink:BiologicalProcess clathrin-dependent endocytosis of virus by host cell Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus. VZ:957 go.json clathrin-mediated endocytosis of virus by host cell|viral entry into host cell via clathrin-mediated endocytosis|viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis|viral penetration via clathrin-mediated endocytosis http://purl.obolibrary.org/obo/GO_0075512 GO:0051567 biolink:BiologicalProcess histone H3-K9 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone. go.json histone H3 K9 methylation|histone H3K9me|histone lysine H3 K9 methylation http://purl.obolibrary.org/obo/GO_0051567 gocheck_do_not_annotate GO:0099501 biolink:CellularComponent exocytic vesicle membrane The lipid bilayer surrounding an exocytic vesicle. go.json secretory vesicle membrane http://purl.obolibrary.org/obo/GO_0099501 GO:0002556 biolink:BiologicalProcess serotonin secretion by basophil The regulated release of serotonin by a basophil or group of basophils. go.json serotonin release by basophil http://purl.obolibrary.org/obo/GO_0002556 GO:0051564 biolink:BiologicalProcess positive regulation of smooth endoplasmic reticulum calcium ion concentration Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum. go.json elevation of calcium ion concentration in smooth endoplasmic reticulum|elevation of smooth ER calcium ion concentration|elevation of smooth endoplasmic reticulum calcium ion concentration|smooth endoplasmic reticulum calcium ion concentration elevation http://purl.obolibrary.org/obo/GO_0051564 GO:0075513 biolink:BiologicalProcess caveolin-mediated endocytosis of virus by host cell Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus. VZ:976 go.json viral entry into host cell via caveolae-mediated endocytosis|viral entry into host cell via caveolin-mediated endocytosis|viral penetration via caveolae-mediated endocytosis followed by endosome disruption http://purl.obolibrary.org/obo/GO_0075513 GO:0002557 biolink:BiologicalProcess histamine secretion by basophil The regulated release of histamine by a basophil or group of basophils. go.json http://purl.obolibrary.org/obo/GO_0002557 GO:0075514 biolink:BiologicalProcess endosome lysis involved in viral entry into host cell Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm. go.json viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis http://purl.obolibrary.org/obo/GO_0075514 GO:0051565 biolink:BiologicalProcess negative regulation of smooth endoplasmic reticulum calcium ion concentration Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum. go.json reduction of calcium ion concentration in smooth ER|reduction of calcium ion concentration in smooth endoplasmic reticulum|reduction of smooth ER calcium ion concentration|reduction of smooth endoplasmic reticulum calcium ion concentration|smooth ER calcium ion concentration reduction|smooth endoplasmic reticulum calcium ion concentration reduction http://purl.obolibrary.org/obo/GO_0051565 GO:0002558 biolink:BiologicalProcess type I hypersensitivity mediated by mast cells An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. go.json http://purl.obolibrary.org/obo/GO_0002558 GO:0002551 biolink:BiologicalProcess mast cell chemotaxis The movement of a mast cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002551 GO:0075515 biolink:BiologicalProcess obsolete viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane OBSOLETE. The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane. go.json viral entry into host cell via caveolae-mediated endocytosis followed by genetic injection through the endosome membrane|viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane True http://purl.obolibrary.org/obo/GO_0075515 GO:0075516 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075516 GO:0002552 biolink:BiologicalProcess serotonin secretion by mast cell The regulated release of serotonin by a mast cell or group of mast cells. go.json serotonin release by mast cell http://purl.obolibrary.org/obo/GO_0002552 GO:0051568 biolink:BiologicalProcess histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. go.json histone H3 K4 methylation|histone H3K4me|histone lysine H3 K4 methylation http://purl.obolibrary.org/obo/GO_0051568 gocheck_do_not_annotate GO:0002553 biolink:BiologicalProcess histamine secretion by mast cell The regulated release of histamine by a mast cell or group of mast cells. go.json http://purl.obolibrary.org/obo/GO_0002553 GO:0075517 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075517 GO:0051569 biolink:BiologicalProcess regulation of histone H3-K4 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. go.json http://purl.obolibrary.org/obo/GO_0051569 GO:0075518 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075518 GO:0002554 biolink:BiologicalProcess serotonin secretion by platelet The regulated release of serotonin by a platelet or group of platelets. go.json serotonin release by platelet http://purl.obolibrary.org/obo/GO_0002554 GO:0075519 biolink:BiologicalProcess microtubule-dependent intracellular transport of viral material The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus. go.json http://purl.obolibrary.org/obo/GO_0075519 GO:0002550 biolink:BiologicalProcess positive regulation of plasma kallikrein-kinin cascade Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade. go.json activation of plasma kallikrein-kinin cascade|stimulation of plasma kallikrein-kinin cascade|up regulation of plasma kallikrein-kinin cascade|up-regulation of plasma kallikrein-kinin cascade|upregulation of plasma kallikrein-kinin cascade http://purl.obolibrary.org/obo/GO_0002550 GO:0099508 biolink:MolecularActivity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. go.json voltage gated ion channel activity involved in regulation of presynaptic membrane potential|voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential|voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential|voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential|voltage-gated ion channel activity involved in regulation of presynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099508 goslim_synapse GO:0099509 biolink:BiologicalProcess regulation of presynaptic cytosolic calcium ion concentration Any process that regulates the concentration of calcium in the presynaptic cytosol. go.json regulation of presynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0099509 goslim_synapse GO:0099506 biolink:BiologicalProcess synaptic vesicle transport along actin filament The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors. go.json http://purl.obolibrary.org/obo/GO_0099506 goslim_synapse GO:0099507 biolink:MolecularActivity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. go.json ligand gated ion channel activity involved in regulation of presynaptic membrane potential|ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential|ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential|ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential http://purl.obolibrary.org/obo/GO_0099507 goslim_synapse GO:0051562 biolink:BiologicalProcess negative regulation of mitochondrial calcium ion concentration Any process that decreases the concentration of calcium ions in mitochondria. go.json mitochondrial calcium ion concentration reduction|reduction of calcium ion concentration in mitochondria|reduction of calcium ion concentration in mitochondrion|reduction of mitochondrial calcium ion concentration http://purl.obolibrary.org/obo/GO_0051562 GO:0099504 biolink:BiologicalProcess synaptic vesicle cycle A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. go.json http://purl.obolibrary.org/obo/GO_0099504 goslim_synapse GO:0002559 biolink:BiologicalProcess type I hypersensitivity mediated by basophils An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. go.json http://purl.obolibrary.org/obo/GO_0002559 GO:0051563 biolink:BiologicalProcess smooth endoplasmic reticulum calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings. go.json calcium ion homeostasis in smooth ER|calcium ion homeostasis in smooth endoplasmic reticulum|regulation of calcium ion concentration in smooth ER|regulation of calcium ion concentration in smooth endoplasmic reticulum|regulation of smooth ER calcium ion concentration|regulation of smooth endoplasmic reticulum calcium ion concentration|smooth ER calcium ion concentration regulation|smooth ER calcium ion homeostasis|smooth endoplasmic reticulum calcium ion concentration regulation http://purl.obolibrary.org/obo/GO_0051563 GO:0099505 biolink:BiologicalProcess regulation of presynaptic membrane potential Any process that modulates the potential difference across a presynaptic membrane. go.json regulation of pre-synaptic membrane potential http://purl.obolibrary.org/obo/GO_0099505 goslim_synapse GO:0051560 biolink:BiologicalProcess mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. go.json calcium ion homeostasis in mitochondria|calcium ion homeostasis in mitochondrion|mitochondrial calcium ion concentration regulation|regulation of calcium ion concentration in mitochondria|regulation of calcium ion concentration in mitochondrion|regulation of mitochondrial calcium ion concentration http://purl.obolibrary.org/obo/GO_0051560 GO:0099502 biolink:BiologicalProcess calcium-dependent activation of synaptic vesicle fusion The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. go.json http://purl.obolibrary.org/obo/GO_0099502 goslim_synapse GO:0075510 biolink:BiologicalProcess macropinocytosis involved in viral entry into host cell Any macropinocytosis that is involved in the uptake of a virus into a host cell. VZ:800 go.json viral entry into host cell via macropinocytosis http://purl.obolibrary.org/obo/GO_0075510 GO:0099503 biolink:CellularComponent secretory vesicle A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. go.json http://purl.obolibrary.org/obo/GO_0099503 goslim_drosophila GO:0051561 biolink:BiologicalProcess positive regulation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria. go.json elevation of calcium ion concentration in mitochondria|elevation of calcium ion concentration in mitochondrion|elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion concentration elevation http://purl.obolibrary.org/obo/GO_0051561 GO:0051577 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051577 GO:0002522 biolink:BiologicalProcess leukocyte migration involved in immune response The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. go.json immune cell migration during immune response|immune cell trafficking during immune response|leucocyte migration during immune response|leucocyte trafficking during immune response|leukocyte trafficking during immune response http://purl.obolibrary.org/obo/GO_0002522 GO:0051578 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051578 GO:0002523 biolink:BiologicalProcess leukocyte migration involved in inflammatory response The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. go.json immune cell migration during inflammatory response|immune cell trafficking during inflammatory response|leucocyte migration during inflammatory response|leucocyte trafficking during inflammatory response|leukocyte migration during inflammatory response|leukocyte trafficking during inflammatory response http://purl.obolibrary.org/obo/GO_0002523 GO:0002524 biolink:BiologicalProcess hypersensitivity An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. Wikipedia:Hypersensitivity go.json hypersensitivity response http://purl.obolibrary.org/obo/GO_0002524 GO:0051575 biolink:MolecularActivity 5'-deoxyribose-5-phosphate lyase activity Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. go.json 5'-deoxyribose phosphate activity|dRP lyase activity|dRPase activity http://purl.obolibrary.org/obo/GO_0051575 GO:0051576 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051576 GO:0002525 biolink:BiologicalProcess acute inflammatory response to non-antigenic stimulus An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma. go.json http://purl.obolibrary.org/obo/GO_0002525 GO:0002520 biolink:BiologicalProcess immune system development The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. go.json http://purl.obolibrary.org/obo/GO_0002520 goslim_drosophila GO:0051579 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051579 GO:0002521 biolink:BiologicalProcess leukocyte differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. go.json immune cell differentiation|leucocyte differentiation http://purl.obolibrary.org/obo/GO_0002521 GO:0051570 biolink:BiologicalProcess regulation of histone H3-K9 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. go.json http://purl.obolibrary.org/obo/GO_0051570 GO:0051573 biolink:BiologicalProcess negative regulation of histone H3-K9 methylation Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. go.json down regulation of histone H3-K9 methylation|down-regulation of histone H3-K9 methylation|downregulation of histone H3-K9 methylation|inhibition of histone H3-K9 methylation http://purl.obolibrary.org/obo/GO_0051573 GO:0002526 biolink:BiologicalProcess acute inflammatory response Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0002526 GO:0051574 biolink:BiologicalProcess positive regulation of histone H3-K9 methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. go.json activation of histone H3-K9 methylation|stimulation of histone H3-K9 methylation|up regulation of histone H3-K9 methylation|up-regulation of histone H3-K9 methylation|upregulation of histone H3-K9 methylation http://purl.obolibrary.org/obo/GO_0051574 GO:0002527 biolink:BiologicalProcess vasodilation involved in acute inflammatory response An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response. go.json vasodilation during acute inflammatory response http://purl.obolibrary.org/obo/GO_0002527 GO:0002528 biolink:BiologicalProcess regulation of vascular permeability involved in acute inflammatory response Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response. go.json regulation of vascular permeability during acute inflammatory response http://purl.obolibrary.org/obo/GO_0002528 GO:0051571 biolink:BiologicalProcess positive regulation of histone H3-K4 methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. go.json activation of histone H3-K4 methylation|stimulation of histone H3-K4 methylation|up regulation of histone H3-K4 methylation|up-regulation of histone H3-K4 methylation|upregulation of histone H3-K4 methylation http://purl.obolibrary.org/obo/GO_0051571 GO:0002529 biolink:BiologicalProcess regulation of plasma kallikrein-kinin cascade Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade. go.json http://purl.obolibrary.org/obo/GO_0002529 GO:0051572 biolink:BiologicalProcess negative regulation of histone H3-K4 methylation Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. go.json down regulation of histone H3-K4 methylation|down-regulation of histone H3-K4 methylation|downregulation of histone H3-K4 methylation|inhibition of histone H3-K4 methylation http://purl.obolibrary.org/obo/GO_0051572 GO:0002533 biolink:BiologicalProcess lysosomal enzyme secretion involved in inflammatory response The regulated release of lysosomal enzymes by a cell as part of an inflammatory response. go.json lysosomal enzyme secretion involved in acute inflammatory response|secretion of lysosomal enzymes involved in acute inflammatory response|secretion of lysosomal enzymes involved in inflammatory response http://purl.obolibrary.org/obo/GO_0002533 GO:0051588 biolink:BiologicalProcess regulation of neurotransmitter transport Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051588 GO:0051589 biolink:BiologicalProcess negative regulation of neurotransmitter transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of neurotransmitter transport|down-regulation of neurotransmitter transport|downregulation of neurotransmitter transport|inhibition of neurotransmitter transport http://purl.obolibrary.org/obo/GO_0051589 GO:0002534 biolink:BiologicalProcess cytokine production involved in inflammatory response The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json cytokine production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002534 gocheck_do_not_annotate GO:0002535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002535 GO:0051586 biolink:BiologicalProcess positive regulation of dopamine uptake involved in synaptic transmission Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell. go.json activation of dopamine uptake involved in synaptic transmission|positive regulation of dopamine import involved in synaptic transmission|stimulation of dopamine uptake involved in synaptic transmission|up regulation of dopamine uptake involved in synaptic transmission|up-regulation of dopamine uptake involved in synaptic transmission|upregulation of dopamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051586 GO:0002536 biolink:BiologicalProcess respiratory burst involved in inflammatory response A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels. go.json oxidative burst during acute inflammatory response|production of reactive oxygen species during acute inflammatory response|respiratory burst involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002536 GO:0051587 biolink:BiologicalProcess inhibition of dopamine uptake involved in synaptic transmission Any process that prevents the activation of the directed movement of dopamine into a cell. go.json inhibition of dopamine import involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051587 GO:0002530 biolink:BiologicalProcess regulation of systemic arterial blood pressure involved in acute-phase response Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein. go.json blood pressure regulation during acute phase response|regulation of systemic arterial blood pressure during acute phase response http://purl.obolibrary.org/obo/GO_0002530 GO:0002531 biolink:BiologicalProcess regulation of heart contraction involved in acute-phase response Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein. go.json regulation of cardiac contraction during acute phase response|regulation of heart contraction during acute phase response http://purl.obolibrary.org/obo/GO_0002531 GO:0002532 biolink:BiologicalProcess production of molecular mediator involved in inflammatory response The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. go.json production of cellular mediator of acute inflammation|production of molecular mediator involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002532 GO:0051580 biolink:BiologicalProcess regulation of neurotransmitter uptake Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. go.json regulation of neurotransmitter import|regulation of neurotransmitter reuptake http://purl.obolibrary.org/obo/GO_0051580 goslim_synapse GO:0051581 biolink:BiologicalProcess negative regulation of neurotransmitter uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. go.json down regulation of neurotransmitter uptake|down-regulation of neurotransmitter uptake|downregulation of neurotransmitter uptake|negative regulation of neurotransmitter import http://purl.obolibrary.org/obo/GO_0051581 GO:0051584 biolink:BiologicalProcess regulation of dopamine uptake involved in synaptic transmission Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell. go.json regulation of dopamine import involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051584 GO:0002537 biolink:BiologicalProcess nitric oxide production involved in inflammatory response The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json nitric oxide production involved in acute inflammatory response|production of nitric oxide involved in acute inflammatory response|production of nitric oxide involved in inflammatory response http://purl.obolibrary.org/obo/GO_0002537 GO:0075530 biolink:BiologicalProcess establishment of latency as a linear episome A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure. go.json establishment of latency as a linear plasmid|establishment of linear plasmid latency http://purl.obolibrary.org/obo/GO_0075530 GO:0051585 biolink:BiologicalProcess negative regulation of dopamine uptake involved in synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell. go.json down regulation of dopamine uptake involved in synaptic transmission|down-regulation of dopamine uptake involved in synaptic transmission|downregulation of dopamine uptake involved in synaptic transmission|negative regulation of dopamine import involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051585 GO:0002538 biolink:BiologicalProcess arachidonic acid metabolite production involved in inflammatory response The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels. go.json arachidonic acid metabolite production involved in acute inflammatory response|production of arachidonic acid metabolites involved in acute inflammatory response|production of arachidonic acid metabolites involved in inflammatory response http://purl.obolibrary.org/obo/GO_0002538 GO:0002539 biolink:BiologicalProcess prostaglandin production involved in inflammatory response The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json prostaglandin production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002539 GO:0051582 biolink:BiologicalProcess positive regulation of neurotransmitter uptake Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. go.json activation of neurotransmitter uptake|positive regulation of neurotransmitter import|stimulation of neurotransmitter uptake|up regulation of neurotransmitter uptake|up-regulation of neurotransmitter uptake|upregulation of neurotransmitter uptake http://purl.obolibrary.org/obo/GO_0051582 GO:0051583 biolink:BiologicalProcess dopamine uptake involved in synaptic transmission The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. go.json dopamine import involved in synaptic transmission|dopamine reuptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051583 GO:1905900 biolink:BiologicalProcess negative regulation of smooth muscle tissue development Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. go.json down regulation of smooth muscle tissue development|down-regulation of smooth muscle tissue development|downregulation of smooth muscle tissue development|inhibition of smooth muscle tissue development http://purl.obolibrary.org/obo/GO_1905900 GO:1905901 biolink:BiologicalProcess positive regulation of smooth muscle tissue development Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. go.json activation of smooth muscle tissue development|up regulation of smooth muscle tissue development|up-regulation of smooth muscle tissue development|upregulation of smooth muscle tissue development http://purl.obolibrary.org/obo/GO_1905901 GO:1905902 biolink:BiologicalProcess regulation of mesoderm formation Any process that modulates the frequency, rate or extent of mesoderm formation. go.json http://purl.obolibrary.org/obo/GO_1905902 GO:1905903 biolink:BiologicalProcess negative regulation of mesoderm formation Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. go.json down regulation of mesoderm formation|down-regulation of mesoderm formation|downregulation of mesoderm formation|inhibition of mesoderm formation http://purl.obolibrary.org/obo/GO_1905903 GO:1905904 biolink:BiologicalProcess positive regulation of mesoderm formation Any process that activates or increases the frequency, rate or extent of mesoderm formation. go.json activation of mesoderm formation|up regulation of mesoderm formation|up-regulation of mesoderm formation|upregulation of mesoderm formation http://purl.obolibrary.org/obo/GO_1905904 GO:1905905 biolink:BiologicalProcess nematode pharyngeal gland morphogenesis The developmental process by which a nematode pharyngeal gland is generated and organized. go.json glandulae pharyngeae morphogenesis|pharynx gland morphogenesis http://purl.obolibrary.org/obo/GO_1905905 GO:1905906 biolink:BiologicalProcess regulation of amyloid fibril formation Any process that modulates the frequency, rate or extent of amyloid fibril formation. go.json regulation of amyloid fibril assembly|regulation of amyloid structure assembly|regulation of amyloid structure formation http://purl.obolibrary.org/obo/GO_1905906 GO:1905907 biolink:BiologicalProcess negative regulation of amyloid fibril formation Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation. go.json down regulation of amyloid fibril assembly|down regulation of amyloid fibril formation|down regulation of amyloid structure assembly|down regulation of amyloid structure formation|down-regulation of amyloid fibril assembly|down-regulation of amyloid fibril formation|down-regulation of amyloid structure assembly|down-regulation of amyloid structure formation|downregulation of amyloid fibril assembly|downregulation of amyloid fibril formation|downregulation of amyloid structure assembly|downregulation of amyloid structure formation|inhibition of amyloid fibril assembly|inhibition of amyloid fibril formation|inhibition of amyloid structure assembly|inhibition of amyloid structure formation|negative regulation of amyloid fibril assembly|negative regulation of amyloid structure assembly|negative regulation of amyloid structure formation http://purl.obolibrary.org/obo/GO_1905907 GO:1905908 biolink:BiologicalProcess positive regulation of amyloid fibril formation Any process that activates or increases the frequency, rate or extent of amyloid fibril formation. go.json activation of amyloid fibril assembly|activation of amyloid fibril formation|activation of amyloid structure assembly|activation of amyloid structure formation|positive regulation of amyloid fibril assembly|positive regulation of amyloid structure assembly|positive regulation of amyloid structure formation|up regulation of amyloid fibril assembly|up regulation of amyloid fibril formation|up regulation of amyloid structure assembly|up regulation of amyloid structure formation|up-regulation of amyloid fibril assembly|up-regulation of amyloid fibril formation|up-regulation of amyloid structure assembly|up-regulation of amyloid structure formation|upregulation of amyloid fibril assembly|upregulation of amyloid fibril formation|upregulation of amyloid structure assembly|upregulation of amyloid structure formation http://purl.obolibrary.org/obo/GO_1905908 GO:1905909 biolink:BiologicalProcess regulation of dauer entry Any process that modulates the frequency, rate or extent of dauer entry. go.json regulation of nematode entry into dormancy http://purl.obolibrary.org/obo/GO_1905909 GO:0051500 biolink:MolecularActivity D-tyrosyl-tRNA(Tyr) deacylase activity Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. go.json http://purl.obolibrary.org/obo/GO_0051500 GO:0051501 biolink:BiologicalProcess diterpene phytoalexin metabolic process The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units. go.json diterpene phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0051501 GO:0051504 biolink:BiologicalProcess diterpene phytoalexin precursor biosynthetic process pathway A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins. MetaCyc:PWY-2981 go.json diterpene phytoalexin precursor anabolism pathway|diterpene phytoalexin precursor formation pathway|diterpene phytoalexin precursor synthesis pathway http://purl.obolibrary.org/obo/GO_0051504 GO:0051505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051505 GO:0051502 biolink:BiologicalProcess diterpene phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses. go.json diterpene phytoalexin anabolism|diterpene phytoalexin biosynthesis|diterpene phytoalexin formation|diterpene phytoalexin synthesis http://purl.obolibrary.org/obo/GO_0051502 GO:0051503 biolink:BiologicalProcess adenine nucleotide transport The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051503 GO:0051508 biolink:MolecularActivity stigmasterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol. MetaCyc:RXN-12126|RHEA:61828 go.json http://purl.obolibrary.org/obo/GO_0051508 GO:0051509 biolink:MolecularActivity tomatidine UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine. go.json http://purl.obolibrary.org/obo/GO_0051509 GO:0051506 biolink:MolecularActivity ergosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol. MetaCyc:RXN-16975|RHEA:61836 go.json http://purl.obolibrary.org/obo/GO_0051506 GO:0051507 biolink:MolecularActivity beta-sitosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol. MetaCyc:RXN-12128|RHEA:61832 go.json http://purl.obolibrary.org/obo/GO_0051507 GO:1905910 biolink:BiologicalProcess negative regulation of dauer entry Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry. go.json down regulation of dauer entry|down regulation of nematode entry into dormancy|down-regulation of dauer entry|down-regulation of nematode entry into dormancy|downregulation of dauer entry|downregulation of nematode entry into dormancy|inhibition of dauer entry|inhibition of nematode entry into dormancy|negative regulation of nematode entry into dormancy http://purl.obolibrary.org/obo/GO_1905910 GO:1905911 biolink:BiologicalProcess positive regulation of dauer entry Any process that activates or increases the frequency, rate or extent of dauer entry. go.json activation of dauer entry|activation of nematode entry into dormancy|positive regulation of nematode entry into dormancy|up regulation of dauer entry|up regulation of nematode entry into dormancy|up-regulation of dauer entry|up-regulation of nematode entry into dormancy|upregulation of dauer entry|upregulation of nematode entry into dormancy http://purl.obolibrary.org/obo/GO_1905911 GO:1905912 biolink:BiologicalProcess regulation of calcium ion export across plasma membrane Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane. go.json regulation of calcium ion efflux from cell|regulation of calcium ion export from cell http://purl.obolibrary.org/obo/GO_1905912 GO:1905913 biolink:BiologicalProcess negative regulation of calcium ion export across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane. go.json down regulation of calcium ion efflux from cell|down regulation of calcium ion export from cell|down-regulation of calcium ion efflux from cell|down-regulation of calcium ion export from cell|downregulation of calcium ion efflux from cell|downregulation of calcium ion export from cell|inhibition of calcium ion efflux from cell|inhibition of calcium ion export from cell|negative regulation of calcium ion efflux from cell|negative regulation of calcium ion export from cell http://purl.obolibrary.org/obo/GO_1905913 GO:1905914 biolink:BiologicalProcess positive regulation of calcium ion export across plasma membrane Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane. go.json activation of calcium ion efflux from cell|activation of calcium ion export from cell|positive regulation of calcium ion efflux from cell|positive regulation of calcium ion export from cell|up regulation of calcium ion efflux from cell|up regulation of calcium ion export from cell|up-regulation of calcium ion efflux from cell|up-regulation of calcium ion export from cell|upregulation of calcium ion efflux from cell|upregulation of calcium ion export from cell http://purl.obolibrary.org/obo/GO_1905914 GO:1905915 biolink:BiologicalProcess regulation of cell differentiation involved in phenotypic switching Any process that modulates the frequency, rate or extent of cell differentiation involved in phenotypic switching. go.json http://purl.obolibrary.org/obo/GO_1905915 GO:1905916 biolink:BiologicalProcess negative regulation of cell differentiation involved in phenotypic switching Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching. go.json down regulation of cell differentiation involved in phenotypic switching|down-regulation of cell differentiation involved in phenotypic switching|downregulation of cell differentiation involved in phenotypic switching|inhibition of cell differentiation involved in phenotypic switching http://purl.obolibrary.org/obo/GO_1905916 GO:1905917 biolink:BiologicalProcess positive regulation of cell differentiation involved in phenotypic switching Any process that activates or increases the frequency, rate or extent of cell differentiation involved in phenotypic switching. go.json activation of cell differentiation involved in phenotypic switching|up regulation of cell differentiation involved in phenotypic switching|up-regulation of cell differentiation involved in phenotypic switching|upregulation of cell differentiation involved in phenotypic switching http://purl.obolibrary.org/obo/GO_1905917 GO:1905918 biolink:BiologicalProcess regulation of CoA-transferase activity Any process that modulates the frequency, rate or extent of CoA-transferase activity. go.json http://purl.obolibrary.org/obo/GO_1905918 gocheck_do_not_annotate GO:1905919 biolink:BiologicalProcess negative regulation of CoA-transferase activity Any process that stops, prevents or reduces the frequency, rate or extent of CoA-transferase activity. go.json down regulation of CoA-transferase activity|down-regulation of CoA-transferase activity|downregulation of CoA-transferase activity|inhibition of CoA-transferase activity http://purl.obolibrary.org/obo/GO_1905919 gocheck_do_not_annotate GO:0036093 biolink:BiologicalProcess germ cell proliferation The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0036093 GO:0036094 biolink:MolecularActivity small molecule binding Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule. go.json http://purl.obolibrary.org/obo/GO_0036094 goslim_agr|goslim_flybase_ribbon GO:0036095 biolink:BiologicalProcess obsolete positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json transcriptional activation of genes involved in invasive growth True http://purl.obolibrary.org/obo/GO_0036095 GO:0036096 biolink:MolecularActivity obsolete 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming the mature 3' end of a miRNA from a pre-miRNA. go.json 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing|exonucleolytic trimming to generate 3' end of miRNA from pre-miRNA True http://purl.obolibrary.org/obo/GO_0036096 GO:0036097 biolink:BiologicalProcess obsolete pre-miRNA 3'-end processing OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA. go.json miRNA 3'-end processing|microRNA 3'-end processing|pre-miRNA 3'-end processing True http://purl.obolibrary.org/obo/GO_0036097 GO:0036098 biolink:BiologicalProcess male germ-line stem cell population maintenance The process by which an organism or tissue maintains a population of male germ-line stem cells. go.json http://purl.obolibrary.org/obo/GO_0036098 GO:0036099 biolink:BiologicalProcess female germ-line stem cell population maintenance The process by which an organism or tissue maintains a population of female germ-line stem cells. go.json http://purl.obolibrary.org/obo/GO_0036099 GO:0036090 biolink:BiologicalProcess cleavage furrow ingression Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. go.json cleavage furrow contraction http://purl.obolibrary.org/obo/GO_0036090 GO:0036091 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0036091 GO:0036092 biolink:BiologicalProcess phosphatidylinositol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. go.json PI(3)P biosynthesis|PtdIns3P biosynthesis|phosphatidylinositol-3-phosphate anabolism|phosphatidylinositol-3-phosphate biosynthesis|phosphatidylinositol-3-phosphate formation|phosphatidylinositol-3-phosphate synthesis http://purl.obolibrary.org/obo/GO_0036092 GO:0036082 biolink:MolecularActivity extracellular phenylacetaldehyde-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts. go.json extracellular phenylacetaldehyde-gated ion channel activity|ionotropic phenylacetaldehyde receptor activity http://purl.obolibrary.org/obo/GO_0036082 GO:0036083 biolink:BiologicalProcess obsolete positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0036083 GO:0036084 biolink:BiologicalProcess GDP-fucose import into endoplasmic reticulum lumen The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. go.json GDP-fucose import into endoplasmic reticulum|GDP-fucose transport across endoplasmic reticulum membrane|GDP-fucose transport into endoplasmic reticulum lumen http://purl.obolibrary.org/obo/GO_0036084 GO:0036085 biolink:BiologicalProcess GDP-fucose import into Golgi lumen The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. go.json GDP-fucose import into Golgi|GDP-fucose transport across Golgi membrane|GDP-fucose transport into Golgi lumen http://purl.obolibrary.org/obo/GO_0036085 GO:0036086 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. go.json positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency http://purl.obolibrary.org/obo/GO_0036086 GO:0036087 biolink:CellularComponent glutathione synthase complex A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer. go.json glutathione synthetase complex http://purl.obolibrary.org/obo/GO_0036087 GO:0036088 biolink:BiologicalProcess D-serine catabolic process The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. go.json D-serine breakdown|D-serine catabolism|D-serine degradation http://purl.obolibrary.org/obo/GO_0036088 GO:0036089 biolink:BiologicalProcess cleavage furrow formation Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell. go.json cleavage furrow positioning http://purl.obolibrary.org/obo/GO_0036089 GO:0002742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002742 GO:0002743 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002743 GO:0002744 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002744 GO:0002745 biolink:BiologicalProcess antigen processing and presentation initiated by receptor mediated uptake of antigen Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor. go.json http://purl.obolibrary.org/obo/GO_0002745 GO:0002740 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002740 GO:0002741 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002741 GO:0085008 biolink:BiologicalProcess obsolete interaction with host via secreted substance released from microneme OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085008 GO:0061040 biolink:BiologicalProcess female gonad morphogenesis The process in which a female gonad is generated and organized. go.json ovary morphogenesis http://purl.obolibrary.org/obo/GO_0061040 GO:1905890 biolink:BiologicalProcess regulation of cellular response to very-low-density lipoprotein particle stimulus Any process that modulates the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus. go.json regulation of cellular response to VLDL particle stimulus http://purl.obolibrary.org/obo/GO_1905890 GO:0085009 biolink:BiologicalProcess obsolete interaction with host mediated by symbiont secreted substance released from Maurer's cleft OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host mediated by symbiont secreted substance released from Maurers cleft True http://purl.obolibrary.org/obo/GO_0085009 GO:0061041 biolink:BiologicalProcess regulation of wound healing Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. go.json http://purl.obolibrary.org/obo/GO_0061041 GO:1905891 biolink:BiologicalProcess obsolete regulation of cellular response to thapsigargin OBSOLETE. Any process that modulates the frequency, rate or extent of cellular response to thapsigargin. go.json True http://purl.obolibrary.org/obo/GO_1905891 GO:0085006 biolink:BiologicalProcess obsolete interaction with host mediated by symbiont secreted substance released from symbiont-containing vacuole OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via a symbiont-containing vacuole, a specialized sac within the host in which the symbiont resides. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole True http://purl.obolibrary.org/obo/GO_0085006 GO:0061042 biolink:BiologicalProcess vascular wound healing Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. go.json http://purl.obolibrary.org/obo/GO_0061042 GO:0061043 biolink:BiologicalProcess regulation of vascular wound healing Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. go.json http://purl.obolibrary.org/obo/GO_0061043 GO:1905892 biolink:BiologicalProcess obsolete negative regulation of cellular response to thapsigargin OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to thapsigargin. go.json down regulation of cellular response to thapsigargin|down-regulation of cellular response to thapsigargin|downregulation of cellular response to thapsigargin|inhibition of cellular response to thapsigargin True http://purl.obolibrary.org/obo/GO_1905892 GO:0085007 biolink:BiologicalProcess obsolete interaction with host via secreted substance released from rhoptry OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085007 GO:0061044 biolink:BiologicalProcess negative regulation of vascular wound healing Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. go.json http://purl.obolibrary.org/obo/GO_0061044 GO:0085004 biolink:BiologicalProcess obsolete interaction with host via secreted substance released from haustorium OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085004 GO:1905893 biolink:BiologicalProcess obsolete positive regulation of cellular response to thapsigargin OBSOLETE. Any process that activates or increases the frequency, rate or extent of cellular response to thapsigargin. go.json activation of cellular response to thapsigargin|up regulation of cellular response to thapsigargin|up-regulation of cellular response to thapsigargin|upregulation of cellular response to thapsigargin True http://purl.obolibrary.org/obo/GO_1905893 GO:1905894 biolink:BiologicalProcess obsolete regulation of cellular response to tunicamycin OBSOLETE. Any process that modulates the frequency, rate or extent of cellular response to tunicamycin. go.json True http://purl.obolibrary.org/obo/GO_1905894 GO:0061045 biolink:BiologicalProcess negative regulation of wound healing Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. go.json http://purl.obolibrary.org/obo/GO_0061045 GO:0085005 biolink:BiologicalProcess obsolete interaction with host via secreted substance released from invasive hyphae OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085005 GO:1905884 biolink:BiologicalProcess negative regulation of triglyceride transport Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride transport. go.json down regulation of triacylglycerol transport|down regulation of triglyceride transport|down-regulation of triacylglycerol transport|down-regulation of triglyceride transport|downregulation of triacylglycerol transport|downregulation of triglyceride transport|inhibition of triacylglycerol transport|inhibition of triglyceride transport|negative regulation of triacylglycerol transport http://purl.obolibrary.org/obo/GO_1905884 GO:0061046 biolink:BiologicalProcess regulation of branching involved in lung morphogenesis Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. go.json http://purl.obolibrary.org/obo/GO_0061046 GO:0085002 biolink:BiologicalProcess obsolete interaction with host mediated by secreted substance released by symbiont from symbiotic structure OBSOLETE. An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis. go.json True http://purl.obolibrary.org/obo/GO_0085002 GO:0085003 biolink:BiologicalProcess obsolete interaction with host via secreted substance released from stylet OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085003 GO:1905885 biolink:BiologicalProcess positive regulation of triglyceride transport Any process that activates or increases the frequency, rate or extent of triglyceride transport. go.json activation of triacylglycerol transport|activation of triglyceride transport|positive regulation of triacylglycerol transport|up regulation of triacylglycerol transport|up regulation of triglyceride transport|up-regulation of triacylglycerol transport|up-regulation of triglyceride transport|upregulation of triacylglycerol transport|upregulation of triglyceride transport http://purl.obolibrary.org/obo/GO_1905885 GO:0061047 biolink:BiologicalProcess positive regulation of branching involved in lung morphogenesis Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. go.json http://purl.obolibrary.org/obo/GO_0061047 GO:0085000 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by type V secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type V secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085000 GO:1905886 biolink:BiologicalProcess obsolete chromatin remodeling involved in meiosis I OBSOLETE. Any chromatin remodeling that is involved in meiosis I. go.json chromatin modeling involved in meiosis I|chromatin modelling involved in meiosis I|chromatin remodelling involved in meiosis I|meiosis-specific chromatin remodeling True http://purl.obolibrary.org/obo/GO_1905886 GO:0061048 biolink:BiologicalProcess negative regulation of branching involved in lung morphogenesis Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. go.json http://purl.obolibrary.org/obo/GO_0061048 GO:0061049 biolink:BiologicalProcess cell growth involved in cardiac muscle cell development The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. go.json cardiac muscle cell hypertrophy|cardiomyocyte growth|heart muscle cell growth http://purl.obolibrary.org/obo/GO_0061049 GO:1905887 biolink:BiologicalProcess autoinducer AI-2 transmembrane transport The process in which (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol (autoinducer AI-2) is transported across a membrane. AI-2 is produced by prokaryotes and is believed to play a role in quorum sensing. go.json (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol transmembrane transport|AI-2 transmembrane transport|autoinducer 2 transmembrane transport http://purl.obolibrary.org/obo/GO_1905887 GO:0085001 biolink:BiologicalProcess formation of stylet for nutrient acquisition The assembly of a stylet, a hollow protrusible spear-like symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by symbiont of stylet for nutrient acquisition from host http://purl.obolibrary.org/obo/GO_0085001 GO:1905888 biolink:BiologicalProcess negative regulation of cellular response to very-low-density lipoprotein particle stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus. go.json down regulation of cellular response to VLDL particle stimulus|down regulation of cellular response to very-low-density lipoprotein particle stimulus|down-regulation of cellular response to VLDL particle stimulus|down-regulation of cellular response to very-low-density lipoprotein particle stimulus|downregulation of cellular response to VLDL particle stimulus|downregulation of cellular response to very-low-density lipoprotein particle stimulus|inhibition of cellular response to VLDL particle stimulus|inhibition of cellular response to very-low-density lipoprotein particle stimulus|negative regulation of cellular response to VLDL particle stimulus http://purl.obolibrary.org/obo/GO_1905888 GO:1905889 biolink:BiologicalProcess positive regulation of cellular response to very-low-density lipoprotein particle stimulus Any process that activates or increases the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus. go.json activation of cellular response to VLDL particle stimulus|activation of cellular response to very-low-density lipoprotein particle stimulus|positive regulation of cellular response to VLDL particle stimulus|up regulation of cellular response to VLDL particle stimulus|up regulation of cellular response to very-low-density lipoprotein particle stimulus|up-regulation of cellular response to VLDL particle stimulus|up-regulation of cellular response to very-low-density lipoprotein particle stimulus|upregulation of cellular response to VLDL particle stimulus|upregulation of cellular response to very-low-density lipoprotein particle stimulus http://purl.obolibrary.org/obo/GO_1905889 GO:0002746 biolink:BiologicalProcess antigen processing and presentation following pinocytosis Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. go.json http://purl.obolibrary.org/obo/GO_0002746 GO:0002747 biolink:BiologicalProcess antigen processing and presentation following phagocytosis Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0002747 GO:0002748 biolink:BiologicalProcess antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR). go.json antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen|antigen processing and presentation initiated by PRR mediated uptake of antigen http://purl.obolibrary.org/obo/GO_0002748 GO:0002749 biolink:BiologicalProcess obsolete antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen OBSOLETE. Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR). go.json antigen processing and presentation initiated by TLR mediated phagocytosis of antigen True http://purl.obolibrary.org/obo/GO_0002749 GO:0002753 biolink:BiologicalProcess cytoplasmic pattern recognition receptor signaling pathway The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. go.json cytoplasmic PRR signaling pathway|cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway|cytoplasmic pathogen receptor signaling pathway|cytoplasmic pattern recognition receptor signalling pathway|cytosolic PAMP receptor signaling pathway|cytosolic pattern recognition receptor signaling pathway http://purl.obolibrary.org/obo/GO_0002753 GO:0002754 biolink:BiologicalProcess endosomal pattern recognition receptor signaling pathway The series of molecular signals initiated by the binding of a ligand to an intracellular vesicle pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. go.json intracellular endosomal pattern recognition receptor signaling pathway|intracellular vesicle PAMP receptor signaling pathway|intracellular vesicle PRR signaling pathway|intracellular vesicle pathogen receptor signaling pathway|intracellular vesicle pattern recognition receptor signaling pathway|intracellular vesicle pattern recognition receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002754 GO:0002755 biolink:BiologicalProcess MyD88-dependent toll-like receptor signaling pathway A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. go.json MyD88-dependent TLR signaling pathway|MyD88-dependent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002755 GO:0002756 biolink:BiologicalProcess MyD88-independent toll-like receptor signaling pathway A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response. go.json MyD88-independent TLR signaling pathway|MyD88-independent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002756 GO:0002750 biolink:BiologicalProcess antigen processing and presentation following macropinocytosis Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis. go.json http://purl.obolibrary.org/obo/GO_0002750 GO:0002751 biolink:BiologicalProcess antigen processing and presentation following receptor mediated endocytosis Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis. go.json http://purl.obolibrary.org/obo/GO_0002751 GO:0002752 biolink:BiologicalProcess cell surface pattern recognition receptor signaling pathway The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. go.json cell surface PAMP receptor signaling pathway|cell surface PRR signaling pathway|cell surface pathogen receptor signaling pathway|cell surface pattern recognition receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002752 GO:0061030 biolink:BiologicalProcess epithelial cell differentiation involved in mammary gland alveolus development The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus. go.json http://purl.obolibrary.org/obo/GO_0061030 GO:0061031 biolink:BiologicalProcess endodermal digestive tract morphogenesis The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm. go.json http://purl.obolibrary.org/obo/GO_0061031 GO:0061032 biolink:BiologicalProcess visceral serous pericardium development The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. go.json epicardium development http://purl.obolibrary.org/obo/GO_0061032 GO:0061033 biolink:BiologicalProcess secretion by lung epithelial cell involved in lung growth The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development. go.json fetal lung liquid secretion http://purl.obolibrary.org/obo/GO_0061033 GO:0061034 biolink:BiologicalProcess olfactory bulb mitral cell layer development The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer. go.json http://purl.obolibrary.org/obo/GO_0061034 GO:0061035 biolink:BiologicalProcess regulation of cartilage development Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. go.json http://purl.obolibrary.org/obo/GO_0061035 GO:1905895 biolink:BiologicalProcess obsolete negative regulation of cellular response to tunicamycin OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to tunicamycin. go.json down regulation of cellular response to tunicamycin|down-regulation of cellular response to tunicamycin|downregulation of cellular response to tunicamycin|inhibition of cellular response to tunicamycin True http://purl.obolibrary.org/obo/GO_1905895 GO:1905896 biolink:BiologicalProcess obsolete positive regulation of cellular response to tunicamycin OBSOLETE. Any process that activates or increases the frequency, rate or extent of cellular response to tunicamycin. go.json activation of cellular response to tunicamycin|up regulation of cellular response to tunicamycin|up-regulation of cellular response to tunicamycin|upregulation of cellular response to tunicamycin True http://purl.obolibrary.org/obo/GO_1905896 GO:0061036 biolink:BiologicalProcess positive regulation of cartilage development Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. go.json http://purl.obolibrary.org/obo/GO_0061036 GO:1905897 biolink:BiologicalProcess regulation of response to endoplasmic reticulum stress Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress. go.json regulation of ER stress response|regulation of cellular response to endoplasmic reticulum stress|regulation of response to ER stress http://purl.obolibrary.org/obo/GO_1905897 GO:0061037 biolink:BiologicalProcess negative regulation of cartilage development Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. go.json http://purl.obolibrary.org/obo/GO_0061037 GO:1905898 biolink:BiologicalProcess positive regulation of response to endoplasmic reticulum stress Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress. go.json activation of ER stress response|activation of cellular response to endoplasmic reticulum stress|activation of response to ER stress|activation of response to endoplasmic reticulum stress|positive regulation of ER stress response|positive regulation of cellular response to endoplasmic reticulum stress|positive regulation of response to ER stress|up regulation of ER stress response|up regulation of cellular response to endoplasmic reticulum stress|up regulation of response to ER stress|up regulation of response to endoplasmic reticulum stress|up-regulation of ER stress response|up-regulation of cellular response to endoplasmic reticulum stress|up-regulation of response to ER stress|up-regulation of response to endoplasmic reticulum stress|upregulation of ER stress response|upregulation of cellular response to endoplasmic reticulum stress|upregulation of response to ER stress|upregulation of response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1905898 GO:0061038 biolink:BiologicalProcess uterus morphogenesis The process in which anatomical structures of the uterus are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061038 GO:1905899 biolink:BiologicalProcess regulation of smooth muscle tissue development Any process that modulates the frequency, rate or extent of smooth muscle tissue development. go.json http://purl.obolibrary.org/obo/GO_1905899 GO:0061039 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061039 GO:0002757 biolink:BiologicalProcess immune response-activating signaling pathway The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response. go.json immune response-activating signal transduction http://purl.obolibrary.org/obo/GO_0002757 GO:0002758 biolink:BiologicalProcess innate immune response-activating signaling pathway The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response. go.json defence response signaling pathway, resistance gene-dependent|defence response signaling pathway, resistance gene-independent|defence response signalling pathway, resistance gene-dependent|defence response signalling pathway, resistance gene-independent|defense response signaling pathway, resistance gene-dependent|defense response signaling pathway, resistance gene-independent|defense response signalling pathway, resistance gene-dependent|effector triggered immunity|effector-triggered immune signaling|effector-triggered immunity http://purl.obolibrary.org/obo/GO_0002758 GO:0002759 biolink:BiologicalProcess regulation of antimicrobial humoral response Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response. go.json http://purl.obolibrary.org/obo/GO_0002759 GO:0002720 biolink:BiologicalProcess positive regulation of cytokine production involved in immune response Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. go.json activation of cytokine production during immune response|positive regulation of cytokine biosynthetic process involved in immune response|positive regulation of cytokine production during immune response|positive regulation of cytokine secretion involved in immune response|stimulation of cytokine production during immune response|up regulation of cytokine production during immune response|up-regulation of cytokine production during immune response|upregulation of cytokine production during immune response http://purl.obolibrary.org/obo/GO_0002720 GO:0099632 biolink:BiologicalProcess protein transport within plasma membrane A process in which protein is transported from one region of the plasma membrane to another. go.json http://purl.obolibrary.org/obo/GO_0099632 GO:0099633 biolink:BiologicalProcess protein localization to postsynaptic specialization membrane A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density). go.json protein localisation in postsynaptic specialization membrane http://purl.obolibrary.org/obo/GO_0099633 GO:0002721 biolink:BiologicalProcess regulation of B cell cytokine production Any process that modulates the frequency, rate, or extent of B cell cytokine production. go.json regulation of B lymphocyte cytokine production|regulation of B-cell cytokine production|regulation of B-lymphocyte cytokine production http://purl.obolibrary.org/obo/GO_0002721 GO:0002722 biolink:BiologicalProcess negative regulation of B cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production. go.json down regulation of B cell cytokine production|down-regulation of B cell cytokine production|downregulation of B cell cytokine production|inhibition of B cell cytokine production|negative regulation of B lymphocyte cytokine production|negative regulation of B-cell cytokine production|negative regulation of B-lymphocyte cytokine production http://purl.obolibrary.org/obo/GO_0002722 GO:0099630 biolink:BiologicalProcess postsynaptic neurotransmitter receptor cycle The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane. go.json http://purl.obolibrary.org/obo/GO_0099630 GO:0002723 biolink:BiologicalProcess positive regulation of B cell cytokine production Any process that activates or increases the frequency, rate, or extent of B cell cytokine production. go.json activation of B cell cytokine production|positive regulation of B lymphocyte cytokine production|positive regulation of B-cell cytokine production|positive regulation of B-lymphocyte cytokine production|stimulation of B cell cytokine production|up regulation of B cell cytokine production|up-regulation of B cell cytokine production|upregulation of B cell cytokine production http://purl.obolibrary.org/obo/GO_0002723 GO:0099631 biolink:CellularComponent postsynaptic endocytic zone cytoplasmic component The cytoplasmic component of the postsynaptic endocytic zone. go.json http://purl.obolibrary.org/obo/GO_0099631 goslim_synapse GO:0061060 biolink:BiologicalProcess negative regulation of peptidoglycan recognition protein signaling pathway Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. go.json negative regulation of peptidoglycan recognition protein signalling pathway http://purl.obolibrary.org/obo/GO_0061060 GO:0061061 biolink:BiologicalProcess muscle structure development The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. go.json http://purl.obolibrary.org/obo/GO_0061061 goslim_drosophila GO:0061062 biolink:BiologicalProcess regulation of nematode larval development Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. go.json http://purl.obolibrary.org/obo/GO_0061062 GO:0061063 biolink:BiologicalProcess positive regulation of nematode larval development Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. go.json http://purl.obolibrary.org/obo/GO_0061063 GO:0061064 biolink:BiologicalProcess negative regulation of nematode larval development Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. go.json http://purl.obolibrary.org/obo/GO_0061064 GO:0085028 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0085028 GO:0061065 biolink:BiologicalProcess regulation of dauer larval development Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. go.json http://purl.obolibrary.org/obo/GO_0061065 GO:0085029 biolink:BiologicalProcess extracellular matrix assembly The aggregation, arrangement and bonding together of the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0085029 GO:0085026 biolink:CellularComponent tubovesicular membrane network A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains. go.json TVM network|TVN http://purl.obolibrary.org/obo/GO_0085026 GO:0061066 biolink:BiologicalProcess positive regulation of dauer larval development Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. go.json http://purl.obolibrary.org/obo/GO_0061066 GO:0061067 biolink:BiologicalProcess negative regulation of dauer larval development Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. go.json http://purl.obolibrary.org/obo/GO_0061067 GO:0085027 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0085027 GO:0061068 biolink:BiologicalProcess urethra development The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. go.json http://purl.obolibrary.org/obo/GO_0061068 GO:0085024 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by Sec complex OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Sec complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification by symbiont of host morphology or physiology via protein secreted by the Sec secretion system True http://purl.obolibrary.org/obo/GO_0085024 GO:0061069 biolink:BiologicalProcess male urethra development The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body. go.json http://purl.obolibrary.org/obo/GO_0061069 GO:0085025 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by Tat complex OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Tat complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification by symbiont of host morphology or physiology via protein secreted by the Tat secretion system True http://purl.obolibrary.org/obo/GO_0085025 GO:0085022 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by type VI secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VI secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085022 GO:0085023 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by type VII secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VII secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085023 GO:0085020 biolink:BiologicalProcess protein K6-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair. go.json protein K6-linked polyubiquitination http://purl.obolibrary.org/obo/GO_0085020 GO:0085021 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by type I secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type I secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085021 GO:0002728 biolink:BiologicalProcess negative regulation of natural killer cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production. go.json down regulation of natural killer cell cytokine production|down-regulation of natural killer cell cytokine production|downregulation of natural killer cell cytokine production|inhibition of natural killer cell cytokine production|negative regulation of NK cell cytokine production http://purl.obolibrary.org/obo/GO_0002728 GO:0002729 biolink:BiologicalProcess positive regulation of natural killer cell cytokine production Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production. go.json activation of natural killer cell cytokine production|positive regulation of NK cell cytokine production|stimulation of natural killer cell cytokine production|up regulation of natural killer cell cytokine production|up-regulation of natural killer cell cytokine production|upregulation of natural killer cell cytokine production http://purl.obolibrary.org/obo/GO_0002729 GO:0099638 biolink:BiologicalProcess endosome to plasma membrane protein transport The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. go.json http://purl.obolibrary.org/obo/GO_0099638 GO:0099639 biolink:BiologicalProcess neurotransmitter receptor transport, endosome to plasma membrane The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. go.json http://purl.obolibrary.org/obo/GO_0099639 goslim_synapse GO:0002724 biolink:BiologicalProcess regulation of T cell cytokine production Any process that modulates the frequency, rate, or extent of T cell cytokine production. go.json regulation of T lymphocyte cytokine production|regulation of T-cell cytokine production|regulation of T-lymphocyte cytokine production http://purl.obolibrary.org/obo/GO_0002724 GO:0099636 biolink:BiologicalProcess cytoplasmic streaming The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains. Wikipedia:Cytoplasmic_streaming go.json http://purl.obolibrary.org/obo/GO_0099636 GO:0002725 biolink:BiologicalProcess negative regulation of T cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. go.json down regulation of T cell cytokine production|down-regulation of T cell cytokine production|downregulation of T cell cytokine production|inhibition of T cell cytokine production|negative regulation of T lymphocyte cytokine production|negative regulation of T-cell cytokine production|negative regulation of T-lymphocyte cytokine production http://purl.obolibrary.org/obo/GO_0002725 GO:0099637 biolink:BiologicalProcess neurotransmitter receptor transport The directed movement of neurotransmitter receptors. go.json http://purl.obolibrary.org/obo/GO_0099637 goslim_synapse GO:0099634 biolink:CellularComponent postsynaptic specialization membrane The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. go.json http://purl.obolibrary.org/obo/GO_0099634 goslim_synapse GO:0002726 biolink:BiologicalProcess positive regulation of T cell cytokine production Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. go.json activation of T cell cytokine production|positive regulation of T lymphocyte cytokine production|positive regulation of T-cell cytokine production|positive regulation of T-lymphocyte cytokine production|stimulation of T cell cytokine production|up regulation of T cell cytokine production|up-regulation of T cell cytokine production|upregulation of T cell cytokine production http://purl.obolibrary.org/obo/GO_0002726 GO:0002727 biolink:BiologicalProcess regulation of natural killer cell cytokine production Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production. go.json regulation of NK cell cytokine production http://purl.obolibrary.org/obo/GO_0002727 GO:0099635 biolink:MolecularActivity voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission. Reactome:R-HSA-9659515 go.json http://purl.obolibrary.org/obo/GO_0099635 goslim_synapse GO:0099643 biolink:BiologicalProcess signal release from synapse Any signal release from a synapse. go.json http://purl.obolibrary.org/obo/GO_0099643 goslim_synapse GO:0002731 biolink:BiologicalProcess negative regulation of dendritic cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. go.json down regulation of dendritic cell cytokine production|down-regulation of dendritic cell cytokine production|downregulation of dendritic cell cytokine production|inhibition of dendritic cell cytokine production http://purl.obolibrary.org/obo/GO_0002731 GO:0099644 biolink:BiologicalProcess protein localization to presynaptic membrane A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane. go.json protein localisation in presynaptic membrane|protein localisation to presynaptic membrane|protein localization in presynaptic membrane http://purl.obolibrary.org/obo/GO_0099644 GO:0002732 biolink:BiologicalProcess positive regulation of dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. go.json activation of dendritic cell cytokine production|stimulation of dendritic cell cytokine production|up regulation of dendritic cell cytokine production|up-regulation of dendritic cell cytokine production|upregulation of dendritic cell cytokine production http://purl.obolibrary.org/obo/GO_0002732 GO:0002733 biolink:BiologicalProcess regulation of myeloid dendritic cell cytokine production Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. go.json http://purl.obolibrary.org/obo/GO_0002733 GO:0099641 biolink:BiologicalProcess anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. go.json anterograde axon cargo transport http://purl.obolibrary.org/obo/GO_0099641 goslim_synapse GO:0099642 biolink:BiologicalProcess retrograde axonal protein transport The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons. go.json retrograde axon cargo transport http://purl.obolibrary.org/obo/GO_0099642 goslim_synapse GO:0002734 biolink:BiologicalProcess negative regulation of myeloid dendritic cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. go.json down regulation of myeloid dendritic cell cytokine production|down-regulation of myeloid dendritic cell cytokine production|downregulation of myeloid dendritic cell cytokine production|inhibition of myeloid dendritic cell cytokine production http://purl.obolibrary.org/obo/GO_0002734 GO:0099640 biolink:BiologicalProcess axo-dendritic protein transport The directed movement of proteins along microtubules in neuron projections. go.json axonal protein transport http://purl.obolibrary.org/obo/GO_0099640 goslim_synapse GO:0002730 biolink:BiologicalProcess regulation of dendritic cell cytokine production Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. go.json http://purl.obolibrary.org/obo/GO_0002730 GO:0061050 biolink:BiologicalProcess regulation of cell growth involved in cardiac muscle cell development Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0061050 GO:0085019 biolink:BiologicalProcess formation of tubovesicular network for nutrient acquisition The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by symbiont of a tubovesicular network for nutrient acquisition from host|formation of a symbiont- induced tubovesicular network for nutrient acquisition from host http://purl.obolibrary.org/obo/GO_0085019 GO:0061051 biolink:BiologicalProcess positive regulation of cell growth involved in cardiac muscle cell development Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0061051 GO:0061052 biolink:BiologicalProcess negative regulation of cell growth involved in cardiac muscle cell development Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0061052 GO:0085017 biolink:BiologicalProcess entry into host cell by a symbiont-containing vacuole The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole. go.json symbiont entry into host cell forming a parasitophorous vacuole|symbiont entry into host cell forming a pathogen-containing vacuole|symbiont entry into host cell forming a symbiont-containing vacuole http://purl.obolibrary.org/obo/GO_0085017 GO:0061053 biolink:BiologicalProcess somite development The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. go.json http://purl.obolibrary.org/obo/GO_0061053 GO:0085018 biolink:BiologicalProcess obsolete maintenance of symbiont-containing vacuole by host OBSOLETE. The process in which a host organism maintains the structure and function of a symbiont-containing vacuole. The symbiont-containing vacuole is a membrane-bounded vacuole within a host cell in which a symbiont organism resides, and can serve to reduce pathogenicity of invading symbionts by restricting them to the vacuolar compartment. go.json maintenance of parasitophorous vacuole|maintenance of pathogen-containing vacuole|maintenance of vacuolar integrity during bacterial infection True http://purl.obolibrary.org/obo/GO_0085018 GO:0061054 biolink:BiologicalProcess dermatome development The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. go.json http://purl.obolibrary.org/obo/GO_0061054 GO:0085015 biolink:BiologicalProcess dormancy maintenance of symbiont in host Any process in which a dormant state is maintained by the symbiont within the host organism. go.json NRP|non-replicating persistence http://purl.obolibrary.org/obo/GO_0085015 GO:0061055 biolink:BiologicalProcess myotome development The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. go.json http://purl.obolibrary.org/obo/GO_0061055 GO:0085016 biolink:BiologicalProcess dormancy exit of symbiont in host Exit from dormant state, also known as resuscitation, of the symbiont within the host organism. go.json resuscitation of symbiont http://purl.obolibrary.org/obo/GO_0085016 GO:0061056 biolink:BiologicalProcess sclerotome development The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. go.json http://purl.obolibrary.org/obo/GO_0061056 GO:0061057 biolink:BiologicalProcess peptidoglycan recognition protein signaling pathway The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides. go.json Imd signaling pathway|Imd signalling pathway|PGRP signaling pathway|immune deficiency pathway|immune deficiency signaling pathway http://purl.obolibrary.org/obo/GO_0061057 GO:0085013 biolink:BiologicalProcess obsolete interaction with host via protein secreted by type VII secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085013 GO:0061058 biolink:BiologicalProcess regulation of peptidoglycan recognition protein signaling pathway Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. go.json regulation of peptidoglycan recognition protein signalling pathway http://purl.obolibrary.org/obo/GO_0061058 GO:0085014 biolink:BiologicalProcess dormancy entry of symbiont in host Entry into a dormant state of the symbiont within the host organism. go.json http://purl.obolibrary.org/obo/GO_0085014 GO:0061059 biolink:BiologicalProcess positive regulation of peptidoglycan recognition protein signaling pathway Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. go.json positive regulation of peptidoglycan recognition protein signalling pathway http://purl.obolibrary.org/obo/GO_0061059 GO:0085011 biolink:BiologicalProcess obsolete interaction with host via protein secreted by Sec complex OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host via protein secreted by Sec secretion system True http://purl.obolibrary.org/obo/GO_0085011 GO:0085012 biolink:BiologicalProcess obsolete interaction with host via protein secreted by Tat complex OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host via protein secreted by Tat secretion system True http://purl.obolibrary.org/obo/GO_0085012 GO:0085010 biolink:BiologicalProcess obsolete interaction with host mediated by secreted substance entering host via endocytosis OBSOLETE. An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0085010 GO:0002739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002739 GO:0002735 biolink:BiologicalProcess positive regulation of myeloid dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. go.json activation of myeloid dendritic cell cytokine production|stimulation of myeloid dendritic cell cytokine production|up regulation of myeloid dendritic cell cytokine production|up-regulation of myeloid dendritic cell cytokine production|upregulation of myeloid dendritic cell cytokine production http://purl.obolibrary.org/obo/GO_0002735 GO:0002736 biolink:BiologicalProcess regulation of plasmacytoid dendritic cell cytokine production Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. go.json http://purl.obolibrary.org/obo/GO_0002736 GO:0002737 biolink:BiologicalProcess negative regulation of plasmacytoid dendritic cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. go.json down regulation of plasmacytoid dendritic cell cytokine production|down-regulation of plasmacytoid dendritic cell cytokine production|downregulation of plasmacytoid dendritic cell cytokine production|inhibition of plasmacytoid dendritic cell cytokine production http://purl.obolibrary.org/obo/GO_0002737 GO:0099645 biolink:BiologicalProcess neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). go.json neurotransmitter receptor localisation in postsynaptic specialization membrane http://purl.obolibrary.org/obo/GO_0099645 goslim_synapse GO:0002738 biolink:BiologicalProcess positive regulation of plasmacytoid dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. go.json activation of plasmacytoid dendritic cell cytokine production|stimulation of plasmacytoid dendritic cell cytokine production|up regulation of plasmacytoid dendritic cell cytokine production|up-regulation of plasmacytoid dendritic cell cytokine production|upregulation of plasmacytoid dendritic cell cytokine production http://purl.obolibrary.org/obo/GO_0002738 GO:0099646 biolink:BiologicalProcess neurotransmitter receptor transport, plasma membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome. go.json http://purl.obolibrary.org/obo/GO_0099646 goslim_synapse GO:0099699 biolink:CellularComponent obsolete integral component of synaptic membrane OBSOLETE. The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099699 GO:0002700 biolink:BiologicalProcess regulation of production of molecular mediator of immune response Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. go.json http://purl.obolibrary.org/obo/GO_0002700 GO:0002701 biolink:BiologicalProcess negative regulation of production of molecular mediator of immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. go.json down regulation of production of molecular mediator of immune response|down-regulation of production of molecular mediator of immune response|downregulation of production of molecular mediator of immune response|inhibition of production of molecular mediator of immune response http://purl.obolibrary.org/obo/GO_0002701 GO:0061080 biolink:BiologicalProcess right horn of sinus venosus development The progression of the right horn of the sinus venosus from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061080 GO:0061081 biolink:BiologicalProcess positive regulation of myeloid leukocyte cytokine production involved in immune response Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. go.json positive regulation of myeloid cell cytokine production involved in immune response http://purl.obolibrary.org/obo/GO_0061081 GO:0061082 biolink:BiologicalProcess myeloid leukocyte cytokine production Any process that contributes to cytokine production by a myeloid cell. go.json http://purl.obolibrary.org/obo/GO_0061082 gocheck_do_not_annotate GO:0061083 biolink:BiologicalProcess regulation of protein refolding Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. go.json http://purl.obolibrary.org/obo/GO_0061083 GO:0061084 biolink:BiologicalProcess negative regulation of protein refolding Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. go.json http://purl.obolibrary.org/obo/GO_0061084 GO:0061085 biolink:BiologicalProcess regulation of histone H3-K27 methylation Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. go.json http://purl.obolibrary.org/obo/GO_0061085 GO:0061086 biolink:BiologicalProcess negative regulation of histone H3-K27 methylation Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. go.json http://purl.obolibrary.org/obo/GO_0061086 GO:0061087 biolink:BiologicalProcess positive regulation of histone H3-K27 methylation Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. go.json http://purl.obolibrary.org/obo/GO_0061087 GO:0061088 biolink:BiologicalProcess obsolete regulation of sequestering of zinc ion OBSOLETE. Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. go.json True http://purl.obolibrary.org/obo/GO_0061088 GO:0061089 biolink:BiologicalProcess obsolete negative regulation of sequestering of zinc ion OBSOLETE. Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. go.json True http://purl.obolibrary.org/obo/GO_0061089 GO:0085044 biolink:BiologicalProcess symbiont-mediated disruption of host cuticle The process in which an organism effects a change that impairs the structure or function of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism of host cuticle|degradation of host cuticle|disassembly by symbiont of host cuticle|https://github.com/geneontology/go-ontology/issues/24127 http://purl.obolibrary.org/obo/GO_0085044 GO:0085042 biolink:CellularComponent periarbuscular membrane A host-derived membrane surrounding the symbiont arbuscule during symbiosis. go.json http://purl.obolibrary.org/obo/GO_0085042 GO:0085040 biolink:CellularComponent obsolete extra-invasive hyphal space OBSOLETE. The space between the symbiont plasma membrane and the extra-invasive hyphal membrane. go.json True http://purl.obolibrary.org/obo/GO_0085040 GO:0085041 biolink:CellularComponent arbuscule Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange. go.json http://purl.obolibrary.org/obo/GO_0085041 GO:0002706 biolink:BiologicalProcess regulation of lymphocyte mediated immunity Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. go.json http://purl.obolibrary.org/obo/GO_0002706 GO:0002707 biolink:BiologicalProcess negative regulation of lymphocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. go.json down regulation of lymphocyte mediated immunity|down-regulation of lymphocyte mediated immunity|downregulation of lymphocyte mediated immunity|inhibition of lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002707 GO:0002708 biolink:BiologicalProcess positive regulation of lymphocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. go.json activation of lymphocyte mediated immunity|stimulation of lymphocyte mediated immunity|up regulation of lymphocyte mediated immunity|up-regulation of lymphocyte mediated immunity|upregulation of lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002708 GO:0002709 biolink:BiologicalProcess regulation of T cell mediated immunity Any process that modulates the frequency, rate, or extent of T cell mediated immunity. go.json regulation of T lymphocyte mediated immunity|regulation of T-cell mediated immunity|regulation of T-lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002709 GO:0002702 biolink:BiologicalProcess positive regulation of production of molecular mediator of immune response Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. go.json activation of production of molecular mediator of immune response|stimulation of production of molecular mediator of immune response|up regulation of production of molecular mediator of immune response|up-regulation of production of molecular mediator of immune response|upregulation of production of molecular mediator of immune response http://purl.obolibrary.org/obo/GO_0002702 GO:0002703 biolink:BiologicalProcess regulation of leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. go.json regulation of immune cell mediated immunity|regulation of leucocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002703 GO:0002704 biolink:BiologicalProcess negative regulation of leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. go.json down regulation of leukocyte mediated immunity|down-regulation of leukocyte mediated immunity|downregulation of leukocyte mediated immunity|inhibition of leukocyte mediated immunity|negative regulation of immune cell mediated immunity|negative regulation of leucocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002704 GO:0002705 biolink:BiologicalProcess positive regulation of leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. go.json activation of leukocyte mediated immunity|positive regulation of immune cell mediated immunity|positive regulation of leucocyte mediated immunity|stimulation of leukocyte mediated immunity|up regulation of leukocyte mediated immunity|up-regulation of leukocyte mediated immunity|upregulation of leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002705 GO:0002710 biolink:BiologicalProcess negative regulation of T cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. go.json down regulation of T cell mediated immunity|down-regulation of T cell mediated immunity|downregulation of T cell mediated immunity|inhibition of T cell mediated immunity|negative regulation of T lymphocyte mediated immunity|negative regulation of T-cell mediated immunity|negative regulation of T-lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002710 GO:0002711 biolink:BiologicalProcess positive regulation of T cell mediated immunity Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. go.json activation of T cell mediated immunity|positive regulation of T lymphocyte mediated immunity|positive regulation of T-cell mediated immunity|positive regulation of T-lymphocyte mediated immunity|stimulation of T cell mediated immunity|up regulation of T cell mediated immunity|up-regulation of T cell mediated immunity|upregulation of T cell mediated immunity http://purl.obolibrary.org/obo/GO_0002711 GO:0002712 biolink:BiologicalProcess regulation of B cell mediated immunity Any process that modulates the frequency, rate, or extent of B cell mediated immunity. go.json regulation of B lymphocyte mediated immunity|regulation of B-cell mediated immunity|regulation of B-lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002712 GO:0061070 biolink:BiologicalProcess female urethra development The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening. go.json http://purl.obolibrary.org/obo/GO_0061070 GO:0061071 biolink:BiologicalProcess urethra epithelium development The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes. go.json http://purl.obolibrary.org/obo/GO_0061071 GO:0061072 biolink:BiologicalProcess iris morphogenesis The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. go.json http://purl.obolibrary.org/obo/GO_0061072 GO:0061073 biolink:BiologicalProcess ciliary body morphogenesis The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. go.json http://purl.obolibrary.org/obo/GO_0061073 GO:0061074 biolink:BiologicalProcess regulation of neural retina development Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. go.json http://purl.obolibrary.org/obo/GO_0061074 GO:0085039 biolink:CellularComponent hyphal membrane A host-derived membrane surrounding the symbiont hypha during infection. go.json extra-invasive hyphal membrane http://purl.obolibrary.org/obo/GO_0085039 GO:0061075 biolink:BiologicalProcess positive regulation of neural retina development Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. go.json http://purl.obolibrary.org/obo/GO_0061075 GO:0061076 biolink:BiologicalProcess negative regulation of neural retina development Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. go.json http://purl.obolibrary.org/obo/GO_0061076 GO:0061077 biolink:BiologicalProcess chaperone-mediated protein folding The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. go.json http://purl.obolibrary.org/obo/GO_0061077 GO:0085037 biolink:CellularComponent extrahaustorial membrane The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0085037 GO:0061078 biolink:BiologicalProcess positive regulation of prostaglandin secretion involved in immune response Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response. go.json positive regulation of prostaglandin secretion during immune response http://purl.obolibrary.org/obo/GO_0061078 GO:0085035 biolink:CellularComponent haustorium A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane. go.json http://purl.obolibrary.org/obo/GO_0085035 GO:0061079 biolink:BiologicalProcess left horn of sinus venosus development The progression of the left horn of the sinus venosus from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061079 GO:0085036 biolink:CellularComponent extrahaustorial matrix The space between the symbiont plasma membrane and the extrahaustorial membrane of the host. go.json http://purl.obolibrary.org/obo/GO_0085036 GO:0085033 biolink:BiologicalProcess induction of host canonical NF-kappaB signal transduction A process that initiates, promotes, or enhances a canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host I-kappaB kinase/NF-kappaB cascade|induction by symbiont of host I-kappaB kinase/NF-kappaB cascade|induction of host I-kappaB kinase/NF-kappaB cascade|positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway|positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway|stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade http://purl.obolibrary.org/obo/GO_0085033 GO:0085034 biolink:BiologicalProcess symbiont-mediated suppression of host canonical NF-kappaB cascade A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host I-kappaB kinase/NF-kappaB cascade|disruption of host canonical NF-kappaB cascade|negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade http://purl.obolibrary.org/obo/GO_0085034 GO:0085031 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0085031 GO:0085032 biolink:BiologicalProcess pertubation of host canonical NF-kappaB cascade A process in which a symbiont alters or subverts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|modulation by symbiont of host NF-kappaB-mediated signal transduction pathway|pertubation of host I-kappaB kinase/NF-kappaB cascade http://purl.obolibrary.org/obo/GO_0085032 GO:0085030 biolink:BiologicalProcess symbiotic process benefiting host A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism. go.json mutualism http://purl.obolibrary.org/obo/GO_0085030 GO:0002717 biolink:BiologicalProcess positive regulation of natural killer cell mediated immunity Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. go.json activation of natural killer cell mediated immunity|positive regulation of NK cell activity|positive regulation of NK cell mediated immunity|positive regulation of natural killer cell activity|stimulation of natural killer cell mediated immunity|up regulation of natural killer cell mediated immunity|up-regulation of natural killer cell mediated immunity|upregulation of natural killer cell mediated immunity http://purl.obolibrary.org/obo/GO_0002717 GO:0002718 biolink:BiologicalProcess regulation of cytokine production involved in immune response Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. go.json regulation of cytokine biosynthetic process involved in immune response|regulation of cytokine production during immune response|regulation of cytokine secretion involved in immune response http://purl.obolibrary.org/obo/GO_0002718 GO:0002719 biolink:BiologicalProcess negative regulation of cytokine production involved in immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. go.json down regulation of cytokine production during immune response|down-regulation of cytokine production during immune response|downregulation of cytokine production during immune response|inhibition of cytokine production during immune response|negative regulation of cytokine biosynthetic process involved in immune response|negative regulation of cytokine production during immune response|negative regulation of cytokine secretion involved in immune response http://purl.obolibrary.org/obo/GO_0002719 GO:0002713 biolink:BiologicalProcess negative regulation of B cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity. go.json down regulation of B cell mediated immunity|down-regulation of B cell mediated immunity|downregulation of B cell mediated immunity|inhibition of B cell mediated immunity|negative regulation of B lymphocyte mediated immunity|negative regulation of B-cell mediated immunity|negative regulation of B-lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002713 GO:0002714 biolink:BiologicalProcess positive regulation of B cell mediated immunity Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. go.json activation of B cell mediated immunity|positive regulation of B lymphocyte mediated immunity|positive regulation of B-cell mediated immunity|positive regulation of B-lymphocyte mediated immunity|stimulation of B cell mediated immunity|up regulation of B cell mediated immunity|up-regulation of B cell mediated immunity|upregulation of B cell mediated immunity http://purl.obolibrary.org/obo/GO_0002714 GO:0002715 biolink:BiologicalProcess regulation of natural killer cell mediated immunity Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. go.json regulation of NK cell mediated immunity|regulation of natural killer cell activity http://purl.obolibrary.org/obo/GO_0002715 GO:0002716 biolink:BiologicalProcess negative regulation of natural killer cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. go.json down regulation of natural killer cell mediated immunity|down-regulation of natural killer cell mediated immunity|downregulation of natural killer cell mediated immunity|inhibition of natural killer cell mediated immunity|negative regulation of NK cell activity|negative regulation of NK cell mediated immunity|negative regulation of natural killer cell activity http://purl.obolibrary.org/obo/GO_0002716 GO:0061090 biolink:BiologicalProcess obsolete positive regulation of sequestering of zinc ion OBSOLETE. Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. go.json True http://purl.obolibrary.org/obo/GO_0061090 GO:0061091 biolink:BiologicalProcess regulation of phospholipid translocation Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. go.json http://purl.obolibrary.org/obo/GO_0061091 GO:0061092 biolink:BiologicalProcess positive regulation of phospholipid translocation Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. go.json http://purl.obolibrary.org/obo/GO_0061092 GO:0061093 biolink:BiologicalProcess negative regulation of phospholipid translocation Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. go.json http://purl.obolibrary.org/obo/GO_0061093 GO:0061094 biolink:BiologicalProcess regulation of turning behavior involved in mating Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. go.json http://purl.obolibrary.org/obo/GO_0061094 GO:0061095 biolink:BiologicalProcess positive regulation of turning behavior involved in mating Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. go.json http://purl.obolibrary.org/obo/GO_0061095 GO:0061096 biolink:BiologicalProcess negative regulation of turning behavior involved in mating Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. go.json http://purl.obolibrary.org/obo/GO_0061096 GO:0061097 biolink:BiologicalProcess regulation of protein tyrosine kinase activity Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0061097 gocheck_do_not_annotate GO:0061098 biolink:BiologicalProcess positive regulation of protein tyrosine kinase activity Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0061098 gocheck_do_not_annotate GO:0061099 biolink:BiologicalProcess negative regulation of protein tyrosine kinase activity Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0061099 gocheck_do_not_annotate GO:0051632 biolink:BiologicalProcess negative regulation of acetylcholine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. go.json down regulation of acetylcholine uptake|down-regulation of acetylcholine uptake|downregulation of acetylcholine uptake|negative regulation of acetylcholine import http://purl.obolibrary.org/obo/GO_0051632 GO:0051633 biolink:BiologicalProcess positive regulation of acetylcholine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. go.json activation of acetylcholine uptake|positive regulation of acetylcholine import|stimulation of acetylcholine uptake|up regulation of acetylcholine uptake|up-regulation of acetylcholine uptake|upregulation of acetylcholine uptake http://purl.obolibrary.org/obo/GO_0051633 GO:0075601 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075601 GO:0051630 biolink:BiologicalProcess acetylcholine uptake The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. go.json acetylcholine import http://purl.obolibrary.org/obo/GO_0051630 GO:0051631 biolink:BiologicalProcess regulation of acetylcholine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. go.json regulation of acetylcholine import http://purl.obolibrary.org/obo/GO_0051631 GO:0051636 biolink:MolecularActivity obsolete Gram-negative bacterial cell surface binding OBSOLETE. Binding to a component on the surface of a Gram-negative bacterial cell. go.json Gram-negative bacterial binding|Gram-negative bacterial cell surface binding|Gram-negative bacterium binding|Gram-negative bacterium cell surface binding|binding to Gram-negative bacterium True http://purl.obolibrary.org/obo/GO_0051636 GO:0051637 biolink:MolecularActivity obsolete Gram-positive bacterial cell surface binding OBSOLETE. Binding to a component on the surface of a Gram-positive bacterium. go.json Gram-positive bacterial binding|Gram-positive bacterial cell surface binding|Gram-positive bacterium binding|Gram-positive bacterium cell surface binding|binding to Gram-positive bacterium True http://purl.obolibrary.org/obo/GO_0051637 GO:0051634 biolink:BiologicalProcess inhibition of acetylcholine uptake Any process that prevents the activation of the directed movement of acetylcholine into a cell. go.json inhibition of acetylcholine import http://purl.obolibrary.org/obo/GO_0051634 GO:0075606 biolink:BiologicalProcess transport of viral material towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane. VZ:990 go.json cytoplasmic inwards viral transport|transport of viral material to nucleus|viral genome transport to host cell nucleus http://purl.obolibrary.org/obo/GO_0075606 GO:0051635 biolink:MolecularActivity obsolete bacterial cell surface binding OBSOLETE. Binding to a component on the surface of a bacterial cell. go.json bacterial binding|bacterial cell surface binding|bacterium binding|bacterium cell surface binding|binding to bacterium True http://purl.obolibrary.org/obo/GO_0051635 GO:0051638 biolink:BiologicalProcess barbed-end actin filament uncapping The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. go.json barbed end F-actin uncapping|barbed end actin filament uncapping|barbed-end F-actin uncapping|plus end F-actin uncapping|plus end actin filament uncapping|plus-end F-actin uncapping|plus-end actin filament uncapping http://purl.obolibrary.org/obo/GO_0051638 GO:0051639 biolink:BiologicalProcess actin filament network formation The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. go.json actin gel biosynthesis|actin gel formation http://purl.obolibrary.org/obo/GO_0051639 GO:1905800 biolink:BiologicalProcess negative regulation of intraciliary retrograde transport Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary retrograde transport. go.json down regulation of intraciliary retrograde transport|down regulation of intraflagellar retrograde transport|down-regulation of intraciliary retrograde transport|down-regulation of intraflagellar retrograde transport|downregulation of intraciliary retrograde transport|downregulation of intraflagellar retrograde transport|inhibition of intraciliary retrograde transport|inhibition of intraflagellar retrograde transport|negative regulation of intraflagellar retrograde transport http://purl.obolibrary.org/obo/GO_1905800 GO:1905801 biolink:BiologicalProcess positive regulation of intraciliary retrograde transport Any process that activates or increases the frequency, rate or extent of intraciliary retrograde transport. go.json activation of intraciliary retrograde transport|activation of intraflagellar retrograde transport|positive regulation of intraflagellar retrograde transport|up regulation of intraciliary retrograde transport|up regulation of intraflagellar retrograde transport|up-regulation of intraciliary retrograde transport|up-regulation of intraflagellar retrograde transport|upregulation of intraciliary retrograde transport|upregulation of intraflagellar retrograde transport http://purl.obolibrary.org/obo/GO_1905801 GO:1905802 biolink:BiologicalProcess regulation of cellular response to manganese ion Any process that modulates the frequency, rate or extent of cellular response to manganese ion. go.json regulation of cellular response to manganese http://purl.obolibrary.org/obo/GO_1905802 GO:1905803 biolink:BiologicalProcess negative regulation of cellular response to manganese ion Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion. go.json down regulation of cellular response to manganese|down regulation of cellular response to manganese ion|down-regulation of cellular response to manganese|down-regulation of cellular response to manganese ion|downregulation of cellular response to manganese|downregulation of cellular response to manganese ion|inhibition of cellular response to manganese|inhibition of cellular response to manganese ion|negative regulation of cellular response to manganese http://purl.obolibrary.org/obo/GO_1905803 GO:1905804 biolink:BiologicalProcess positive regulation of cellular response to manganese ion Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion. go.json activation of cellular response to manganese|activation of cellular response to manganese ion|positive regulation of cellular response to manganese|up regulation of cellular response to manganese|up regulation of cellular response to manganese ion|up-regulation of cellular response to manganese|up-regulation of cellular response to manganese ion|upregulation of cellular response to manganese|upregulation of cellular response to manganese ion http://purl.obolibrary.org/obo/GO_1905804 GO:1905805 biolink:BiologicalProcess excitatory synapse pruning The disaggregation of an excitatory synapse into its constituent components. go.json synapse clearance|synapse disassembly|synapse elimination|synapse removal http://purl.obolibrary.org/obo/GO_1905805 GO:1905806 biolink:BiologicalProcess regulation of synapse pruning Any process that modulates the frequency, rate or extent of synapse pruning. go.json regulation of synapse clearance|regulation of synapse disassembly|regulation of synapse elimination|regulation of synapse removal http://purl.obolibrary.org/obo/GO_1905806 goslim_synapse GO:1905807 biolink:BiologicalProcess negative regulation of synapse pruning Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. go.json down regulation of synapse disassembly|down-regulation of synapse disassembly|downregulation of synapse disassembly|inhibition of synapse disassembly|regulation of synapse clearance|regulation of synapse disassembly|regulation of synapse elimination|regulation of synapse removal http://purl.obolibrary.org/obo/GO_1905807 GO:1905808 biolink:BiologicalProcess positive regulation of synapse pruning Any process that activates or increases the frequency, rate or extent of synapse pruning. go.json activation of synapse disassembly|regulation of synapse clearance|regulation of synapse disassembly|regulation of synapse elimination|regulation of synapse removal|up regulation of synapse disassembly|up-regulation of synapse disassembly|upregulation of synapse disassembly http://purl.obolibrary.org/obo/GO_1905808 GO:1905809 biolink:BiologicalProcess negative regulation of synapse organization Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. go.json down regulation of synapse development|down regulation of synapse morphogenesis|down regulation of synapse organisation|down regulation of synapse organization|down regulation of synapse organization and biogenesis|down-regulation of synapse development|down-regulation of synapse morphogenesis|down-regulation of synapse organisation|down-regulation of synapse organization|down-regulation of synapse organization and biogenesis|downregulation of synapse development|downregulation of synapse morphogenesis|downregulation of synapse organisation|downregulation of synapse organization|downregulation of synapse organization and biogenesis|inhibition of synapse development|inhibition of synapse morphogenesis|inhibition of synapse organisation|inhibition of synapse organization|inhibition of synapse organization and biogenesis|negative regulation of synapse development|negative regulation of synapse morphogenesis|negative regulation of synapse organisation|negative regulation of synapse organization and biogenesis http://purl.obolibrary.org/obo/GO_1905809 GO:0051643 biolink:BiologicalProcess endoplasmic reticulum localization Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. go.json ER localization|endoplasmic reticulum localisation|establishment and maintenance of ER localization http://purl.obolibrary.org/obo/GO_0051643 GO:0051644 biolink:BiologicalProcess plastid localization Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell. go.json establishment and maintenance of plastid localization|plastid localisation http://purl.obolibrary.org/obo/GO_0051644 GO:0051641 biolink:BiologicalProcess cellular localization A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. go.json cellular localisation|establishment and maintenance of cellular localization|establishment and maintenance of localization in cell or cell membrane|intracellular localization|localization within cell|single organism cellular localization|single-organism cellular localization http://purl.obolibrary.org/obo/GO_0051641 goslim_pir GO:0051642 biolink:BiologicalProcess centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. go.json centrosome localisation|establishment and maintenance of centrosome localization http://purl.obolibrary.org/obo/GO_0051642 GO:0051647 biolink:BiologicalProcess nucleus localization Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. go.json cell nucleus localization|establishment and maintenance of nucleus localization|localization of nucleus|nucleus localisation http://purl.obolibrary.org/obo/GO_0051647 GO:0051648 biolink:BiologicalProcess vesicle localization Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. go.json cytoplasmic vesicle localization|establishment and maintenance of vesicle localization|vesicle localisation http://purl.obolibrary.org/obo/GO_0051648 GO:0051645 biolink:BiologicalProcess Golgi localization Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. go.json Golgi apparatus localization|Golgi body localization|Golgi localisation|establishment and maintenance of Golgi localization http://purl.obolibrary.org/obo/GO_0051645 GO:0051646 biolink:BiologicalProcess mitochondrion localization Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. go.json establishment and maintenance of mitochondria localization|establishment and maintenance of mitochondrion localization|localization of mitochondria|localization of mitochondrion|mitochondria localization|mitochondrial localization|mitochondrion localisation http://purl.obolibrary.org/obo/GO_0051646 GO:0051649 biolink:BiologicalProcess establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. go.json establishment of cellular localization|establishment of intracellular localization|establishment of localisation in cell|establishment of localization within cell|positioning within cell http://purl.obolibrary.org/obo/GO_0051649 GO:1905810 biolink:BiologicalProcess regulation of excitatory synapse pruning Any process that modulates the frequency, rate or extent of excitatory synapse pruning. go.json regulation of synapse clearance|regulation of synapse disassembly|regulation of synapse elimination|regulation of synapse removal http://purl.obolibrary.org/obo/GO_1905810 GO:1905811 biolink:BiologicalProcess negative regulation of excitatory synapse pruning Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning. go.json down regulation of excitatory synapse disassembly|down-regulation of excitatory synapse disassembly|downregulation of excitatory synapse disassembly|inhibition of excitatory synapse disassembly|regulation of synapse clearance|regulation of synapse disassembly|regulation of synapse elimination|regulation of synapse removal http://purl.obolibrary.org/obo/GO_1905811 GO:1905812 biolink:BiologicalProcess regulation of motor neuron axon guidance Any process that modulates the frequency, rate or extent of motor neuron axon guidance. go.json regulation of motoneuron axon guidance|regulation of motor axon guidance|regulation of motor axon pathfinding http://purl.obolibrary.org/obo/GO_1905812 GO:1905813 biolink:BiologicalProcess negative regulation of motor neuron axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron axon guidance. go.json down regulation of motoneuron axon guidance|down regulation of motor axon guidance|down regulation of motor axon pathfinding|down regulation of motor neuron axon guidance|down-regulation of motoneuron axon guidance|down-regulation of motor axon guidance|down-regulation of motor axon pathfinding|down-regulation of motor neuron axon guidance|downregulation of motoneuron axon guidance|downregulation of motor axon guidance|downregulation of motor axon pathfinding|downregulation of motor neuron axon guidance|inhibition of motoneuron axon guidance|inhibition of motor axon guidance|inhibition of motor axon pathfinding|inhibition of motor neuron axon guidance|negative regulation of motoneuron axon guidance|negative regulation of motor axon guidance|negative regulation of motor axon pathfinding http://purl.obolibrary.org/obo/GO_1905813 GO:1905814 biolink:BiologicalProcess positive regulation of motor neuron axon guidance Any process that activates or increases the frequency, rate or extent of motor neuron axon guidance. go.json activation of motoneuron axon guidance|activation of motor axon guidance|activation of motor axon pathfinding|activation of motor neuron axon guidance|positive regulation of motoneuron axon guidance|positive regulation of motor axon guidance|positive regulation of motor axon pathfinding|up regulation of motoneuron axon guidance|up regulation of motor axon guidance|up regulation of motor axon pathfinding|up regulation of motor neuron axon guidance|up-regulation of motoneuron axon guidance|up-regulation of motor axon guidance|up-regulation of motor axon pathfinding|up-regulation of motor neuron axon guidance|upregulation of motoneuron axon guidance|upregulation of motor axon guidance|upregulation of motor axon pathfinding|upregulation of motor neuron axon guidance http://purl.obolibrary.org/obo/GO_1905814 GO:1905815 biolink:BiologicalProcess regulation of dorsal/ventral axon guidance Any process that modulates the frequency, rate or extent of dorsal/ventral axon guidance. go.json regulation of dorsal-ventral axon guidance|regulation of dorsal/ventral axon pathfinding|regulation of dorsoventral axon guidance http://purl.obolibrary.org/obo/GO_1905815 GO:1905816 biolink:BiologicalProcess negative regulation of dorsal/ventral axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of dorsal/ventral axon guidance. go.json down regulation of dorsal-ventral axon guidance|down regulation of dorsal/ventral axon guidance|down regulation of dorsal/ventral axon pathfinding|down regulation of dorsoventral axon guidance|down-regulation of dorsal-ventral axon guidance|down-regulation of dorsal/ventral axon guidance|down-regulation of dorsal/ventral axon pathfinding|down-regulation of dorsoventral axon guidance|downregulation of dorsal-ventral axon guidance|downregulation of dorsal/ventral axon guidance|downregulation of dorsal/ventral axon pathfinding|downregulation of dorsoventral axon guidance|inhibition of dorsal-ventral axon guidance|inhibition of dorsal/ventral axon guidance|inhibition of dorsal/ventral axon pathfinding|inhibition of dorsoventral axon guidance|negative regulation of dorsal-ventral axon guidance|negative regulation of dorsal/ventral axon pathfinding|negative regulation of dorsoventral axon guidance http://purl.obolibrary.org/obo/GO_1905816 GO:1905817 biolink:BiologicalProcess positive regulation of dorsal/ventral axon guidance Any process that activates or increases the frequency, rate or extent of dorsal/ventral axon guidance. go.json activation of dorsal-ventral axon guidance|activation of dorsal/ventral axon guidance|activation of dorsal/ventral axon pathfinding|activation of dorsoventral axon guidance|positive regulation of dorsal-ventral axon guidance|positive regulation of dorsal/ventral axon pathfinding|positive regulation of dorsoventral axon guidance|up regulation of dorsal-ventral axon guidance|up regulation of dorsal/ventral axon guidance|up regulation of dorsal/ventral axon pathfinding|up regulation of dorsoventral axon guidance|up-regulation of dorsal-ventral axon guidance|up-regulation of dorsal/ventral axon guidance|up-regulation of dorsal/ventral axon pathfinding|up-regulation of dorsoventral axon guidance|upregulation of dorsal-ventral axon guidance|upregulation of dorsal/ventral axon guidance|upregulation of dorsal/ventral axon pathfinding|upregulation of dorsoventral axon guidance http://purl.obolibrary.org/obo/GO_1905817 GO:1905818 biolink:BiologicalProcess regulation of chromosome separation Any process that modulates the frequency, rate or extent of chromosome separation. go.json regulation of chromatid release|regulation of rDNA separation http://purl.obolibrary.org/obo/GO_1905818 GO:1905819 biolink:BiologicalProcess negative regulation of chromosome separation Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation. go.json down regulation of chromatid release|down regulation of chromosome separation|down regulation of rDNA separation|down-regulation of chromatid release|down-regulation of chromosome separation|down-regulation of rDNA separation|downregulation of chromatid release|downregulation of chromosome separation|downregulation of rDNA separation|inhibition of chromatid release|inhibition of chromosome separation|inhibition of rDNA separation|negative regulation of chromatid release|negative regulation of rDNA separation http://purl.obolibrary.org/obo/GO_1905819 GO:0051640 biolink:BiologicalProcess organelle localization Any process in which an organelle is transported to, and/or maintained in, a specific location. go.json establishment and maintenance of organelle localization|organelle localisation http://purl.obolibrary.org/obo/GO_0051640 goslim_pir GO:0002687 biolink:BiologicalProcess positive regulation of leukocyte migration Any process that activates or increases the frequency, rate, or extent of leukocyte migration. go.json activation of leukocyte migration|positive regulation of immune cell migration|positive regulation of leucocyte migration|stimulation of leukocyte migration|up regulation of leukocyte migration|up-regulation of leukocyte migration|upregulation of leukocyte migration http://purl.obolibrary.org/obo/GO_0002687 GO:0051654 biolink:BiologicalProcess establishment of mitochondrion localization The directed movement of the mitochondrion to a specific location. go.json establishment of mitochondria localization|establishment of mitochondrion localisation|mitochondria positioning|mitochondrial migration|mitochondrion positioning http://purl.obolibrary.org/obo/GO_0051654 GO:0051655 biolink:BiologicalProcess maintenance of vesicle location Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of vesicle localization http://purl.obolibrary.org/obo/GO_0051655 GO:0002688 biolink:BiologicalProcess regulation of leukocyte chemotaxis Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. go.json regulation of immune cell chemotaxis|regulation of leucocyte chemotaxis http://purl.obolibrary.org/obo/GO_0002688 GO:0002689 biolink:BiologicalProcess negative regulation of leukocyte chemotaxis Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. go.json down regulation of leukocyte chemotaxis|down-regulation of leukocyte chemotaxis|downregulation of leukocyte chemotaxis|inhibition of leukocyte chemotaxis|negative regulation of immune cell chemotaxis|negative regulation of leucocyte chemotaxis http://purl.obolibrary.org/obo/GO_0002689 GO:0051652 biolink:BiologicalProcess maintenance of chromosome location Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of chromosome localization http://purl.obolibrary.org/obo/GO_0051652 GO:0051653 biolink:BiologicalProcess spindle localization Any process in which is the spindle is transported to, and/or maintained in, a specific location. go.json establishment and maintenance of spindle localization|spindle localisation http://purl.obolibrary.org/obo/GO_0051653 GO:0051658 biolink:BiologicalProcess maintenance of nucleus location Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of cell nucleus location|maintenance of nucleus localization http://purl.obolibrary.org/obo/GO_0051658 GO:0002683 biolink:BiologicalProcess negative regulation of immune system process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. go.json down regulation of immune system process|down-regulation of immune system process|downregulation of immune system process|inhibition of immune system process http://purl.obolibrary.org/obo/GO_0002683 GO:0002684 biolink:BiologicalProcess positive regulation of immune system process Any process that activates or increases the frequency, rate, or extent of an immune system process. go.json activation of immune system process|stimulation of immune system process|up regulation of immune system process|up-regulation of immune system process|upregulation of immune system process http://purl.obolibrary.org/obo/GO_0002684 GO:0051659 biolink:BiologicalProcess maintenance of mitochondrion location Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of mitochondria localization|maintenance of mitochondrion localization http://purl.obolibrary.org/obo/GO_0051659 GO:0051656 biolink:BiologicalProcess establishment of organelle localization The directed movement of an organelle to a specific location. go.json establishment of organelle localisation http://purl.obolibrary.org/obo/GO_0051656 GO:0002685 biolink:BiologicalProcess regulation of leukocyte migration Any process that modulates the frequency, rate, or extent of leukocyte migration. go.json regulation of immune cell migration|regulation of leucocyte migration http://purl.obolibrary.org/obo/GO_0002685 GO:0002686 biolink:BiologicalProcess negative regulation of leukocyte migration Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. go.json down regulation of leukocyte migration|down-regulation of leukocyte migration|downregulation of leukocyte migration|inhibition of leukocyte migration|negative regulation of immune cell migration|negative regulation of leucocyte migration http://purl.obolibrary.org/obo/GO_0002686 GO:0051657 biolink:BiologicalProcess maintenance of organelle location Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of organelle localization http://purl.obolibrary.org/obo/GO_0051657 GO:0002680 biolink:BiologicalProcess pro-T cell lineage commitment The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell. go.json pro-T cell fate commitment|pro-T lymphocyte fate commitment|pro-T lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002680 GO:0002681 biolink:BiologicalProcess somatic recombination of T cell receptor gene segments The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments. go.json somatic recombination of TCR gene segments http://purl.obolibrary.org/obo/GO_0002681 GO:0002682 biolink:BiologicalProcess regulation of immune system process Any process that modulates the frequency, rate, or extent of an immune system process. go.json http://purl.obolibrary.org/obo/GO_0002682 GO:1905820 biolink:BiologicalProcess positive regulation of chromosome separation Any process that activates or increases the frequency, rate or extent of chromosome separation. go.json activation of chromatid release|activation of chromosome separation|activation of rDNA separation|positive regulation of chromatid release|positive regulation of rDNA separation|up regulation of chromatid release|up regulation of chromosome separation|up regulation of rDNA separation|up-regulation of chromatid release|up-regulation of chromosome separation|up-regulation of rDNA separation|upregulation of chromatid release|upregulation of chromosome separation|upregulation of rDNA separation http://purl.obolibrary.org/obo/GO_1905820 GO:1905821 biolink:BiologicalProcess positive regulation of chromosome condensation Any process that activates or increases the frequency, rate or extent of chromosome condensation. go.json activation of chromosome condensation|activation of eukaryotic chromosome condensation|activation of nuclear chromosome condensation|positive regulation of eukaryotic chromosome condensation|positive regulation of nuclear chromosome condensation|up regulation of chromosome condensation|up regulation of eukaryotic chromosome condensation|up regulation of nuclear chromosome condensation|up-regulation of chromosome condensation|up-regulation of eukaryotic chromosome condensation|up-regulation of nuclear chromosome condensation|upregulation of chromosome condensation|upregulation of eukaryotic chromosome condensation|upregulation of nuclear chromosome condensation http://purl.obolibrary.org/obo/GO_1905821 GO:1905822 biolink:BiologicalProcess regulation of mitotic sister chromatid arm separation Any process that modulates the frequency, rate or extent of mitotic sister chromatid arm separation. go.json http://purl.obolibrary.org/obo/GO_1905822 GO:1905823 biolink:BiologicalProcess negative regulation of mitotic sister chromatid arm separation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid arm separation. go.json down regulation of mitotic sister chromatid arm separation|down-regulation of mitotic sister chromatid arm separation|downregulation of mitotic sister chromatid arm separation|inhibition of mitotic sister chromatid arm separation http://purl.obolibrary.org/obo/GO_1905823 GO:1905824 biolink:BiologicalProcess positive regulation of mitotic sister chromatid arm separation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid arm separation. go.json activation of mitotic sister chromatid arm separation|up regulation of mitotic sister chromatid arm separation|up-regulation of mitotic sister chromatid arm separation|upregulation of mitotic sister chromatid arm separation http://purl.obolibrary.org/obo/GO_1905824 GO:1905825 biolink:BiologicalProcess regulation of selenocysteine metabolic process Any process that modulates the frequency, rate or extent of selenocysteine metabolic process. go.json regulation of selenocysteine metabolism http://purl.obolibrary.org/obo/GO_1905825 GO:1905826 biolink:BiologicalProcess negative regulation of selenocysteine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine metabolic process. go.json down regulation of selenocysteine metabolic process|down regulation of selenocysteine metabolism|down-regulation of selenocysteine metabolic process|down-regulation of selenocysteine metabolism|downregulation of selenocysteine metabolic process|downregulation of selenocysteine metabolism|inhibition of selenocysteine metabolic process|inhibition of selenocysteine metabolism|negative regulation of selenocysteine metabolism http://purl.obolibrary.org/obo/GO_1905826 GO:1905827 biolink:BiologicalProcess positive regulation of selenocysteine metabolic process Any process that activates or increases the frequency, rate or extent of selenocysteine metabolic process. go.json activation of selenocysteine metabolic process|activation of selenocysteine metabolism|positive regulation of selenocysteine metabolism|up regulation of selenocysteine metabolic process|up regulation of selenocysteine metabolism|up-regulation of selenocysteine metabolic process|up-regulation of selenocysteine metabolism|upregulation of selenocysteine metabolic process|upregulation of selenocysteine metabolism http://purl.obolibrary.org/obo/GO_1905827 GO:1905828 biolink:BiologicalProcess regulation of prostaglandin catabolic process Any process that modulates the frequency, rate or extent of prostaglandin catabolic process. go.json regulation of prostaglandin breakdown|regulation of prostaglandin catabolism|regulation of prostaglandin degradation http://purl.obolibrary.org/obo/GO_1905828 GO:1905829 biolink:BiologicalProcess negative regulation of prostaglandin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin catabolic process. go.json down regulation of prostaglandin breakdown|down regulation of prostaglandin catabolic process|down regulation of prostaglandin catabolism|down regulation of prostaglandin degradation|down-regulation of prostaglandin breakdown|down-regulation of prostaglandin catabolic process|down-regulation of prostaglandin catabolism|down-regulation of prostaglandin degradation|downregulation of prostaglandin breakdown|downregulation of prostaglandin catabolic process|downregulation of prostaglandin catabolism|downregulation of prostaglandin degradation|inhibition of prostaglandin breakdown|inhibition of prostaglandin catabolic process|inhibition of prostaglandin catabolism|inhibition of prostaglandin degradation|negative regulation of prostaglandin breakdown|negative regulation of prostaglandin catabolism|negative regulation of prostaglandin degradation http://purl.obolibrary.org/obo/GO_1905829 GO:0051650 biolink:BiologicalProcess establishment of vesicle localization The directed movement of a vesicle to a specific location. go.json establishment of vesicle localisation http://purl.obolibrary.org/obo/GO_0051650 GO:0051651 biolink:BiologicalProcess maintenance of location in cell Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. go.json cellular retention|cellular sequestering|cellular storage|intracellular retention|intracellular sequestering|intracellular storage|maintenance of cellular localization|maintenance of intracellular localization|maintenance of localization in cell|maintenance of localization within cell|retention within cell|sequestering within cell|storage within cell http://purl.obolibrary.org/obo/GO_0051651 GO:0002698 biolink:BiologicalProcess negative regulation of immune effector process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. go.json down regulation of immune effector process|down-regulation of immune effector process|downregulation of immune effector process|inhibition of immune effector process http://purl.obolibrary.org/obo/GO_0002698 GO:0051665 biolink:BiologicalProcess membrane raft localization Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. go.json establishment and maintenance of membrane raft localization|lipid raft localization|membrane raft localisation http://purl.obolibrary.org/obo/GO_0051665 GO:0002699 biolink:BiologicalProcess positive regulation of immune effector process Any process that activates or increases the frequency, rate, or extent of an immune effector process. go.json activation of immune effector process|stimulation of immune effector process|up regulation of immune effector process|up-regulation of immune effector process|upregulation of immune effector process http://purl.obolibrary.org/obo/GO_0002699 GO:0051666 biolink:BiologicalProcess actin cortical patch localization Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. go.json actin cortical patch localisation|establishment and maintenance of actin cortical patch localization http://purl.obolibrary.org/obo/GO_0051666 GO:0051663 biolink:BiologicalProcess oocyte nucleus localization involved in oocyte dorsal/ventral axis specification The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. go.json establishment and maintenance of oocyte nucleus localization during oocyte axis determination|oocyte axis determination, oocyte nucleus localization|oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification|oocyte nucleus localization during oocyte axis determination|oocyte nucleus localization involved in oocyte dorsal-ventral axis specification|oocyte nucleus localization involved in oocyte dorsal/ventral axis determination|oocyte nucleus localization involved in oocyte dorsoventral axis specification http://purl.obolibrary.org/obo/GO_0051663 GO:0051664 biolink:BiologicalProcess nuclear pore localization Any process in which nuclear pores are transported to, or maintained in, a specific location. go.json establishment and maintenance of nuclear pore localization|nuclear pore distribution|nuclear pore localisation|positioning of nuclear pores http://purl.obolibrary.org/obo/GO_0051664 GO:0002694 biolink:BiologicalProcess regulation of leukocyte activation Any process that modulates the frequency, rate, or extent of leukocyte activation. go.json regulation of immune cell activation|regulation of leucocyte activation http://purl.obolibrary.org/obo/GO_0002694 GO:0051669 biolink:MolecularActivity fructan beta-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans. EC:3.2.1.80|MetaCyc:3.2.1.80-RXN go.json beta-D-fructan fructohydrolase activity|exo-beta-D-fructosidase activity|exo-beta-fructosidase activity|fructan b-fructosidase activity|fructan exohydrolase activity|fructanase activity|polysaccharide beta-fructofuranosidase activity http://purl.obolibrary.org/obo/GO_0051669 GO:0002695 biolink:BiologicalProcess negative regulation of leukocyte activation Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. go.json down regulation of leukocyte activation|down-regulation of leukocyte activation|downregulation of leukocyte activation|inhibition of leukocyte activation|negative regulation of immune cell activation|negative regulation of leucocyte activation http://purl.obolibrary.org/obo/GO_0002695 GO:0051667 biolink:BiologicalProcess establishment of plastid localization The directed movement of a plastid to a specific location in the cell. go.json establishment of plastid localisation http://purl.obolibrary.org/obo/GO_0051667 GO:0002696 biolink:BiologicalProcess positive regulation of leukocyte activation Any process that activates or increases the frequency, rate, or extent of leukocyte activation. go.json activation of leukocyte activation|positive regulation of immune cell activation|positive regulation of leucocyte activation|stimulation of leukocyte activation|up regulation of leukocyte activation|up-regulation of leukocyte activation|upregulation of leukocyte activation http://purl.obolibrary.org/obo/GO_0002696 GO:0051668 biolink:BiologicalProcess localization within membrane Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. go.json establishment and maintenance of localization in membrane|establishment and maintenance of position in membrane|localisation within membrane|localization to membrane|positioning within membrane http://purl.obolibrary.org/obo/GO_0051668 GO:0002697 biolink:BiologicalProcess regulation of immune effector process Any process that modulates the frequency, rate, or extent of an immune effector process. go.json http://purl.obolibrary.org/obo/GO_0002697 GO:0002690 biolink:BiologicalProcess positive regulation of leukocyte chemotaxis Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. go.json activation of leukocyte chemotaxis|positive regulation of immune cell chemotaxis|positive regulation of leucocyte chemotaxis|stimulation of leukocyte chemotaxis|up regulation of leukocyte chemotaxis|up-regulation of leukocyte chemotaxis|upregulation of leukocyte chemotaxis http://purl.obolibrary.org/obo/GO_0002690 GO:0002691 biolink:BiologicalProcess regulation of cellular extravasation Any process that modulates the frequency, rate, or extent of cellular extravasation. go.json http://purl.obolibrary.org/obo/GO_0002691 GO:0002692 biolink:BiologicalProcess negative regulation of cellular extravasation Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation. go.json down regulation of cellular extravasation|down-regulation of cellular extravasation|downregulation of cellular extravasation|inhibition of cellular extravasation http://purl.obolibrary.org/obo/GO_0002692 GO:0002693 biolink:BiologicalProcess positive regulation of cellular extravasation Any process that activates or increases the frequency, rate, or extent of cellular extravasation. go.json activation of cellular extravasation|stimulation of cellular extravasation|up regulation of cellular extravasation|up-regulation of cellular extravasation|upregulation of cellular extravasation http://purl.obolibrary.org/obo/GO_0002693 GO:1905830 biolink:BiologicalProcess positive regulation of prostaglandin catabolic process Any process that activates or increases the frequency, rate or extent of prostaglandin catabolic process. go.json activation of prostaglandin breakdown|activation of prostaglandin catabolic process|activation of prostaglandin catabolism|activation of prostaglandin degradation|positive regulation of prostaglandin breakdown|positive regulation of prostaglandin catabolism|positive regulation of prostaglandin degradation|up regulation of prostaglandin breakdown|up regulation of prostaglandin catabolic process|up regulation of prostaglandin catabolism|up regulation of prostaglandin degradation|up-regulation of prostaglandin breakdown|up-regulation of prostaglandin catabolic process|up-regulation of prostaglandin catabolism|up-regulation of prostaglandin degradation|upregulation of prostaglandin breakdown|upregulation of prostaglandin catabolic process|upregulation of prostaglandin catabolism|upregulation of prostaglandin degradation http://purl.obolibrary.org/obo/GO_1905830 GO:1905831 biolink:BiologicalProcess negative regulation of spindle assembly Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly. go.json down regulation of bipolar spindle biosynthesis|down regulation of bipolar spindle formation|down regulation of spindle assembly|down regulation of spindle biosynthesis|down regulation of spindle formation|down-regulation of bipolar spindle biosynthesis|down-regulation of bipolar spindle formation|down-regulation of spindle assembly|down-regulation of spindle biosynthesis|down-regulation of spindle formation|downregulation of bipolar spindle biosynthesis|downregulation of bipolar spindle formation|downregulation of spindle assembly|downregulation of spindle biosynthesis|downregulation of spindle formation|inhibition of bipolar spindle biosynthesis|inhibition of bipolar spindle formation|inhibition of spindle assembly|inhibition of spindle biosynthesis|inhibition of spindle formation|negative regulation of bipolar spindle biosynthesis|negative regulation of bipolar spindle formation|negative regulation of spindle biosynthesis|negative regulation of spindle formation http://purl.obolibrary.org/obo/GO_1905831 GO:1905832 biolink:BiologicalProcess positive regulation of spindle assembly Any process that activates or increases the frequency, rate or extent of spindle assembly. go.json activation of bipolar spindle biosynthesis|activation of bipolar spindle formation|activation of spindle assembly|activation of spindle biosynthesis|activation of spindle formation|positive regulation of bipolar spindle biosynthesis|positive regulation of bipolar spindle formation|positive regulation of spindle biosynthesis|positive regulation of spindle formation|up regulation of bipolar spindle biosynthesis|up regulation of bipolar spindle formation|up regulation of spindle assembly|up regulation of spindle biosynthesis|up regulation of spindle formation|up-regulation of bipolar spindle biosynthesis|up-regulation of bipolar spindle formation|up-regulation of spindle assembly|up-regulation of spindle biosynthesis|up-regulation of spindle formation|upregulation of bipolar spindle biosynthesis|upregulation of bipolar spindle formation|upregulation of spindle assembly|upregulation of spindle biosynthesis|upregulation of spindle formation http://purl.obolibrary.org/obo/GO_1905832 GO:1905833 biolink:BiologicalProcess negative regulation of microtubule nucleation Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. go.json down regulation of microtubule nucleation|down-regulation of microtubule nucleation|downregulation of microtubule nucleation|inhibition of microtubule nucleation http://purl.obolibrary.org/obo/GO_1905833 GO:1905834 biolink:BiologicalProcess response to pyrimidine ribonucleotide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus. go.json http://purl.obolibrary.org/obo/GO_1905834 GO:1905835 biolink:BiologicalProcess cellular response to pyrimidine ribonucleotide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus. go.json http://purl.obolibrary.org/obo/GO_1905835 GO:1905836 biolink:BiologicalProcess response to triterpenoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus. go.json http://purl.obolibrary.org/obo/GO_1905836 GO:1905837 biolink:BiologicalProcess cellular response to triterpenoid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus. go.json http://purl.obolibrary.org/obo/GO_1905837 GO:1905838 biolink:BiologicalProcess regulation of telomeric D-loop disassembly Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly. go.json http://purl.obolibrary.org/obo/GO_1905838 GO:1905839 biolink:BiologicalProcess negative regulation of telomeric D-loop disassembly Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly. go.json down regulation of telomeric D-loop disassembly|down-regulation of telomeric D-loop disassembly|downregulation of telomeric D-loop disassembly|inhibition of telomeric D-loop disassembly http://purl.obolibrary.org/obo/GO_1905839 GO:0051661 biolink:BiologicalProcess maintenance of centrosome location Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of centrosome localization http://purl.obolibrary.org/obo/GO_0051661 GO:0051662 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051662 GO:0051660 biolink:BiologicalProcess establishment of centrosome localization The directed movement of the centrosome to a specific location. go.json centrosome positioning|establishment of centrosome localisation http://purl.obolibrary.org/obo/GO_0051660 GO:0002665 biolink:BiologicalProcess negative regulation of T cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction. go.json down regulation of T cell tolerance induction|down-regulation of T cell tolerance induction|downregulation of T cell tolerance induction|inhibition of T cell tolerance induction|negative regulation of T lymphocyte tolerance induction|negative regulation of T-cell tolerance induction|negative regulation of T-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002665 GO:0099610 biolink:BiologicalProcess action potential initiation The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate. go.json action potential firing|action potential triggering http://purl.obolibrary.org/obo/GO_0099610 GO:0051676 biolink:BiologicalProcess pullulan metabolic process The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. go.json pullulan metabolism http://purl.obolibrary.org/obo/GO_0051676 GO:0002666 biolink:BiologicalProcess positive regulation of T cell tolerance induction Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction. go.json activation of T cell tolerance induction|positive regulation of T lymphocyte tolerance induction|positive regulation of T-cell tolerance induction|positive regulation of T-lymphocyte tolerance induction|stimulation of T cell tolerance induction|up regulation of T cell tolerance induction|up-regulation of T cell tolerance induction|upregulation of T cell tolerance induction http://purl.obolibrary.org/obo/GO_0002666 GO:0051677 biolink:BiologicalProcess pullulan biosynthetic process The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. go.json http://purl.obolibrary.org/obo/GO_0051677 GO:0099611 biolink:BiologicalProcess regulation of action potential firing threshold Any process that regulates the potential at which an axon potential is triggered. go.json http://purl.obolibrary.org/obo/GO_0099611 GO:0051674 biolink:BiologicalProcess localization of cell Any process in which a cell is transported to, and/or maintained in, a specific location. go.json cell localization|establishment and maintenance of cell localization|establishment and maintenance of localization of cell|localisation of cell http://purl.obolibrary.org/obo/GO_0051674 GO:0002667 biolink:BiologicalProcess regulation of T cell anergy Any process that modulates the frequency, rate, or extent of T cell anergy. go.json regulation of T lymphocyte anergy|regulation of T-cell anergy|regulation of T-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002667 GO:0002668 biolink:BiologicalProcess negative regulation of T cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy. go.json down regulation of T cell anergy|down-regulation of T cell anergy|downregulation of T cell anergy|inhibition of T cell anergy|negative regulation of T lymphocyte anergy|negative regulation of T-cell anergy|negative regulation of T-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002668 GO:0051675 biolink:MolecularActivity isopullulanase activity Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose). EC:3.2.1.57|MetaCyc:3.2.1.57-RXN go.json pullulan 4-glucanohydrolase (isopanose-forming) activity http://purl.obolibrary.org/obo/GO_0051675 GO:0002661 biolink:BiologicalProcess regulation of B cell tolerance induction Any process that modulates the frequency, rate, or extent of B cell tolerance induction. go.json regulation of B lymphocyte tolerance induction|regulation of B-cell tolerance induction|regulation of B-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002661 GO:0002662 biolink:BiologicalProcess negative regulation of B cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction. go.json down regulation of B cell tolerance induction|down-regulation of B cell tolerance induction|downregulation of B cell tolerance induction|inhibition of B cell tolerance induction|negative regulation of B lymphocyte tolerance induction|negative regulation of B-cell tolerance induction|negative regulation of B-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002662 GO:0002663 biolink:BiologicalProcess positive regulation of B cell tolerance induction Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction. go.json activation of B cell tolerance induction|positive regulation of B lymphocyte tolerance induction|positive regulation of B-cell tolerance induction|positive regulation of B-lymphocyte tolerance induction|stimulation of B cell tolerance induction|up regulation of B cell tolerance induction|up-regulation of B cell tolerance induction|upregulation of B cell tolerance induction http://purl.obolibrary.org/obo/GO_0002663 GO:0051678 biolink:BiologicalProcess pullulan catabolic process The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. go.json http://purl.obolibrary.org/obo/GO_0051678 GO:0051679 biolink:BiologicalProcess 6-alpha-maltosylglucose metabolic process The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose. go.json 6-alpha-maltosylglucose metabolism|isopanose metabolic process|isopanose metabolism http://purl.obolibrary.org/obo/GO_0051679 GO:0002664 biolink:BiologicalProcess regulation of T cell tolerance induction Any process that modulates the frequency, rate, or extent of T cell tolerance induction. go.json regulation of T lymphocyte tolerance induction|regulation of T-cell tolerance induction|regulation of T-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002664 GO:0002660 biolink:BiologicalProcess positive regulation of peripheral tolerance induction Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction. go.json activation of peripheral tolerance induction|stimulation of peripheral tolerance induction|up regulation of peripheral tolerance induction|up-regulation of peripheral tolerance induction|upregulation of peripheral tolerance induction http://purl.obolibrary.org/obo/GO_0002660 GO:0061000 biolink:BiologicalProcess negative regulation of dendritic spine development Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061000 GO:0061001 biolink:BiologicalProcess regulation of dendritic spine morphogenesis Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0061001 GO:1905850 biolink:BiologicalProcess positive regulation of forward locomotion Any process that activates or increases the frequency, rate or extent of forward locomotion. go.json activation of forward locomotion|up regulation of forward locomotion|up-regulation of forward locomotion|upregulation of forward locomotion http://purl.obolibrary.org/obo/GO_1905850 GO:0061002 biolink:BiologicalProcess negative regulation of dendritic spine morphogenesis Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0061002 GO:1905840 biolink:BiologicalProcess positive regulation of telomeric D-loop disassembly Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly. go.json activation of telomeric D-loop disassembly|up regulation of telomeric D-loop disassembly|up-regulation of telomeric D-loop disassembly|upregulation of telomeric D-loop disassembly http://purl.obolibrary.org/obo/GO_1905840 GO:1905841 biolink:BiologicalProcess response to oxidopamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1905841 GO:0061003 biolink:BiologicalProcess positive regulation of dendritic spine morphogenesis Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0061003 GO:1905842 biolink:BiologicalProcess cellular response to oxidopamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1905842 GO:0061004 biolink:BiologicalProcess pattern specification involved in kidney development Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate. go.json kidney pattern formation|kidney pattern specification|pattern formation involved in kidney development http://purl.obolibrary.org/obo/GO_0061004 GO:1905843 biolink:BiologicalProcess regulation of cellular response to gamma radiation Any process that modulates the frequency, rate or extent of cellular response to gamma radiation. go.json regulation of cellular response to gamma ray|regulation of cellular response to gamma-ray photon http://purl.obolibrary.org/obo/GO_1905843 GO:0061005 biolink:BiologicalProcess cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061005 GO:1905844 biolink:BiologicalProcess negative regulation of cellular response to gamma radiation Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. go.json down regulation of cellular response to gamma radiation|down regulation of cellular response to gamma ray|down regulation of cellular response to gamma-ray photon|down-regulation of cellular response to gamma radiation|down-regulation of cellular response to gamma ray|down-regulation of cellular response to gamma-ray photon|downregulation of cellular response to gamma radiation|downregulation of cellular response to gamma ray|downregulation of cellular response to gamma-ray photon|inhibition of cellular response to gamma radiation|inhibition of cellular response to gamma ray|inhibition of cellular response to gamma-ray photon|negative regulation of cellular response to gamma ray|negative regulation of cellular response to gamma-ray photon http://purl.obolibrary.org/obo/GO_1905844 GO:0061006 biolink:BiologicalProcess regulation of cell proliferation involved in kidney morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney. go.json http://purl.obolibrary.org/obo/GO_0061006 GO:1905845 biolink:BiologicalProcess positive regulation of cellular response to gamma radiation Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation. go.json activation of cellular response to gamma radiation|activation of cellular response to gamma ray|activation of cellular response to gamma-ray photon|positive regulation of cellular response to gamma ray|positive regulation of cellular response to gamma-ray photon|up regulation of cellular response to gamma radiation|up regulation of cellular response to gamma ray|up regulation of cellular response to gamma-ray photon|up-regulation of cellular response to gamma radiation|up-regulation of cellular response to gamma ray|up-regulation of cellular response to gamma-ray photon|upregulation of cellular response to gamma radiation|upregulation of cellular response to gamma ray|upregulation of cellular response to gamma-ray photon http://purl.obolibrary.org/obo/GO_1905845 GO:0061007 biolink:BiologicalProcess hepaticobiliary system process An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. go.json hepatobiliary system process http://purl.obolibrary.org/obo/GO_0061007 goslim_generic GO:0061008 biolink:BiologicalProcess hepaticobiliary system development The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. go.json hepatobiliary system development http://purl.obolibrary.org/obo/GO_0061008 GO:1905846 biolink:BiologicalProcess regulation of cellular response to oxidopamine Any process that modulates the frequency, rate or extent of cellular response to oxidopamine. go.json http://purl.obolibrary.org/obo/GO_1905846 GO:1905847 biolink:BiologicalProcess negative regulation of cellular response to oxidopamine Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidopamine. go.json down regulation of cellular response to oxidopamine|down-regulation of cellular response to oxidopamine|downregulation of cellular response to oxidopamine|inhibition of cellular response to oxidopamine http://purl.obolibrary.org/obo/GO_1905847 GO:0061009 biolink:BiologicalProcess common bile duct development The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. go.json CBD development|EHBD development|bile duct development|extrahepatic bile duct development http://purl.obolibrary.org/obo/GO_0061009 GO:1905848 biolink:BiologicalProcess positive regulation of cellular response to oxidopamine Any process that activates or increases the frequency, rate or extent of cellular response to oxidopamine. go.json activation of cellular response to oxidopamine|up regulation of cellular response to oxidopamine|up-regulation of cellular response to oxidopamine|upregulation of cellular response to oxidopamine http://purl.obolibrary.org/obo/GO_1905848 GO:0099618 biolink:MolecularActivity UDP-glucuronic acid dehydrogenase activity Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+. EC:1.1.1.305|RHEA:24702 go.json UDP-GlcUA decarboxylase activity http://purl.obolibrary.org/obo/GO_0099618 GO:1905849 biolink:BiologicalProcess negative regulation of forward locomotion Any process that stops, prevents or reduces the frequency, rate or extent of forward locomotion. go.json down regulation of forward locomotion|down-regulation of forward locomotion|downregulation of forward locomotion|inhibition of forward locomotion http://purl.obolibrary.org/obo/GO_1905849 GO:0099619 biolink:MolecularActivity UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. EC:2.1.2.13|RHEA:24706 go.json 10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity|ArnAFT activity|UDP-L-Ara4N formyltransferase activity http://purl.obolibrary.org/obo/GO_0099619 GO:0099616 biolink:CellularComponent extrinsic component of matrix side of mitochondrial inner membrane The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0099616 GO:0099617 biolink:CellularComponent matrix side of mitochondrial inner membrane The side (leaflet) of the mitochondrial inner membrane that faces the matrix. go.json http://purl.obolibrary.org/obo/GO_0099617 GO:0002669 biolink:BiologicalProcess positive regulation of T cell anergy Any process that activates or increases the frequency, rate, or extent of T cell anergy. go.json activation of T cell anergy|positive regulation of T lymphocyte anergy|positive regulation of T-cell anergy|positive regulation of T-lymphocyte anergy|stimulation of T cell anergy|up regulation of T cell anergy|up-regulation of T cell anergy|upregulation of T cell anergy http://purl.obolibrary.org/obo/GO_0002669 GO:0051672 biolink:BiologicalProcess obsolete catabolism by organism of cell wall peptidoglycan in other organism OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism. go.json catabolic process of cell wall peptidoglycans of other organism|catabolism of cell wall peptidoglycans of other organism|cell wall catabolic process in other organism|cell wall catabolism in other organism|cell wall peptidoglycan catabolic process in another organism True http://purl.obolibrary.org/obo/GO_0051672 GO:0099614 biolink:BiologicalProcess protein localization to spore cell wall A process in which a protein is transported, tethered to or otherwise maintained in a spore cell wall. go.json protein targeting to spore cell wall http://purl.obolibrary.org/obo/GO_0099614 GO:0099615 biolink:MolecularActivity (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor. go.json D-2HG-pyruvate transhydrogenase activity|R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity http://purl.obolibrary.org/obo/GO_0099615 GO:0051673 biolink:BiologicalProcess disruption of plasma membrane integrity in another organism The disruption of the cell membrane of another organism, leading to damage or temporary subversion of the membrane. go.json cytolysis, by membrane disruption, in other organism|disruption by organism of host cell membrane|disruption by virus of host cell membrane|disruption of membrane integrity in another organism|membrane disruption in another organism|membrane disruption in other organism|perturbation of plasma membrane integrity in another organism http://purl.obolibrary.org/obo/GO_0051673 GO:0099612 biolink:BiologicalProcess protein localization to axon A process in which a protein is transported to or maintained in a location within an axon. go.json http://purl.obolibrary.org/obo/GO_0099612 GO:0051670 biolink:MolecularActivity inulinase activity Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin. EC:3.2.1.7|MetaCyc:3.2.1.7-RXN go.json 2,1-beta-D-fructan fructanohydrolase activity|endo-inulinase activity|exoinulinase activity|indoinulinase activity|inulase activity http://purl.obolibrary.org/obo/GO_0051670 GO:0051671 biolink:BiologicalProcess obsolete induction of autolysin activity in other organism OBSOLETE. Any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism. go.json activation of autolysin activity in another organism|activation of autolysis in other organism|activation of autolytic activity in other organism|induction of autolysin activity in another organism|induction of autolysis in other organism|induction of autolytic activity in other organism|positive regulation of autolysin activity in another organism True http://purl.obolibrary.org/obo/GO_0051671 GO:0099613 biolink:BiologicalProcess protein localization to cell wall The process of directing proteins towards the cell-wall. go.json http://purl.obolibrary.org/obo/GO_0099613 GO:0099621 biolink:MolecularActivity undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate. EC:2.4.2.53|MetaCyc:RXN0-3521|RHEA:27722 go.json Ara4FN transferase activity|undecaprenyl phosphate-L-Ara4FN transferase activity|undecaprenyl-phosphate Ara4FN transferase activity http://purl.obolibrary.org/obo/GO_0099621 GO:0002676 biolink:BiologicalProcess regulation of chronic inflammatory response Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0002676 GO:0051687 biolink:BiologicalProcess maintenance of spindle location Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of spindle localization http://purl.obolibrary.org/obo/GO_0051687 GO:0002677 biolink:BiologicalProcess negative regulation of chronic inflammatory response Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response. go.json down regulation of chronic inflammatory response|down-regulation of chronic inflammatory response|downregulation of chronic inflammatory response|inhibition of chronic inflammatory response http://purl.obolibrary.org/obo/GO_0002677 GO:0099622 biolink:BiologicalProcess cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0099622 GO:0051688 biolink:BiologicalProcess maintenance of plastid location Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of plastid localization http://purl.obolibrary.org/obo/GO_0051688 GO:0002678 biolink:BiologicalProcess positive regulation of chronic inflammatory response Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response. go.json activation of chronic inflammatory response|stimulation of chronic inflammatory response|up regulation of chronic inflammatory response|up-regulation of chronic inflammatory response|upregulation of chronic inflammatory response http://purl.obolibrary.org/obo/GO_0002678 GO:0051685 biolink:BiologicalProcess maintenance of ER location Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of ER localization|maintenance of endoplasmic reticulum localization http://purl.obolibrary.org/obo/GO_0051685 GO:0051686 biolink:BiologicalProcess establishment of ER localization The directed movement of the endoplasmic reticulum to a specific location. go.json establishment of ER localisation|establishment of endoplasmic reticulum localization http://purl.obolibrary.org/obo/GO_0051686 GO:0099620 biolink:MolecularActivity UDP-4-amino-4-deoxy-L-arabinose aminotransferase Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate. EC:2.6.1.87|RHEA:24710 go.json UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase|UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase|UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase|UDP-Ara4O aminotransferase|UDP-L-Ara4N transaminase http://purl.obolibrary.org/obo/GO_0099620 GO:0002679 biolink:BiologicalProcess respiratory burst involved in defense response A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0002679 GO:0002672 biolink:BiologicalProcess positive regulation of B cell anergy Any process that activates or increases the frequency, rate, or extent of B cell anergy. go.json activation of B cell anergy|positive regulation of B lymphocyte anergy|positive regulation of B-cell anergy|positive regulation of B-lymphocyte anergy|stimulation of B cell anergy|up regulation of B cell anergy|up-regulation of B cell anergy|upregulation of B cell anergy http://purl.obolibrary.org/obo/GO_0002672 GO:0002673 biolink:BiologicalProcess regulation of acute inflammatory response Any process that modulates the frequency, rate, or extent of an acute inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0002673 GO:0002674 biolink:BiologicalProcess negative regulation of acute inflammatory response Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. go.json down regulation of acute inflammatory response|down-regulation of acute inflammatory response|downregulation of acute inflammatory response|inhibition of acute inflammatory response http://purl.obolibrary.org/obo/GO_0002674 GO:0051689 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051689 GO:0002675 biolink:BiologicalProcess positive regulation of acute inflammatory response Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. go.json activation of acute inflammatory response|stimulation of acute inflammatory response|up regulation of acute inflammatory response|up-regulation of acute inflammatory response|upregulation of acute inflammatory response http://purl.obolibrary.org/obo/GO_0002675 GO:0002670 biolink:BiologicalProcess regulation of B cell anergy Any process that modulates the frequency, rate, or extent of B cell anergy. go.json regulation of B lymphocyte anergy|regulation of B-cell anergy|regulation of B-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002670 GO:0002671 biolink:BiologicalProcess negative regulation of B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy. go.json down regulation of B cell anergy|down-regulation of B cell anergy|downregulation of B cell anergy|inhibition of B cell anergy|negative regulation of B lymphocyte anergy|negative regulation of B-cell anergy|negative regulation of B-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002671 GO:1905860 biolink:BiologicalProcess positive regulation of heparan sulfate proteoglycan binding Any process that activates or increases the frequency, rate or extent of heparan sulfate proteoglycan binding. go.json activation of heparan sulfate proteoglycan binding|activation of heparin proteoglycan binding|positive regulation of heparin proteoglycan binding|up regulation of heparan sulfate proteoglycan binding|up regulation of heparin proteoglycan binding|up-regulation of heparan sulfate proteoglycan binding|up-regulation of heparin proteoglycan binding|upregulation of heparan sulfate proteoglycan binding|upregulation of heparin proteoglycan binding http://purl.obolibrary.org/obo/GO_1905860 gocheck_do_not_annotate GO:1905861 biolink:BiologicalProcess intranuclear rod assembly The aggregation, arrangement and bonding together of a set of components to form an intranuclear rod. go.json intranuclear actin rod assembly|intranuclear actin rod formation|intranuclear rod formation http://purl.obolibrary.org/obo/GO_1905861 GO:1905851 biolink:BiologicalProcess negative regulation of backward locomotion Any process that stops, prevents or reduces the frequency, rate or extent of backward locomotion. go.json down regulation of backward locomotion|down-regulation of backward locomotion|downregulation of backward locomotion|inhibition of backward locomotion http://purl.obolibrary.org/obo/GO_1905851 GO:1905852 biolink:BiologicalProcess positive regulation of backward locomotion Any process that activates or increases the frequency, rate or extent of backward locomotion. go.json activation of backward locomotion|up regulation of backward locomotion|up-regulation of backward locomotion|upregulation of backward locomotion http://purl.obolibrary.org/obo/GO_1905852 GO:1905853 biolink:BiologicalProcess regulation of heparan sulfate binding Any process that modulates the frequency, rate or extent of heparan sulfate binding. go.json http://purl.obolibrary.org/obo/GO_1905853 gocheck_do_not_annotate GO:1905854 biolink:BiologicalProcess negative regulation of heparan sulfate binding Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding. go.json down regulation of heparan sulfate binding|down-regulation of heparan sulfate binding|downregulation of heparan sulfate binding|inhibition of heparan sulfate binding http://purl.obolibrary.org/obo/GO_1905854 gocheck_do_not_annotate GO:1905855 biolink:BiologicalProcess positive regulation of heparan sulfate binding Any process that activates or increases the frequency, rate or extent of heparan sulfate binding. go.json activation of heparan sulfate binding|up regulation of heparan sulfate binding|up-regulation of heparan sulfate binding|upregulation of heparan sulfate binding http://purl.obolibrary.org/obo/GO_1905855 gocheck_do_not_annotate GO:1905856 biolink:BiologicalProcess negative regulation of pentose-phosphate shunt Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt. go.json http://purl.obolibrary.org/obo/GO_1905856 GO:1905857 biolink:BiologicalProcess positive regulation of pentose-phosphate shunt Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt. go.json http://purl.obolibrary.org/obo/GO_1905857 GO:1905858 biolink:BiologicalProcess regulation of heparan sulfate proteoglycan binding Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding. go.json regulation of heparin proteoglycan binding http://purl.obolibrary.org/obo/GO_1905858 gocheck_do_not_annotate GO:1905859 biolink:BiologicalProcess negative regulation of heparan sulfate proteoglycan binding Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding. go.json down regulation of heparan sulfate proteoglycan binding|down regulation of heparin proteoglycan binding|down-regulation of heparan sulfate proteoglycan binding|down-regulation of heparin proteoglycan binding|downregulation of heparan sulfate proteoglycan binding|downregulation of heparin proteoglycan binding|inhibition of heparan sulfate proteoglycan binding|inhibition of heparin proteoglycan binding|negative regulation of heparin proteoglycan binding http://purl.obolibrary.org/obo/GO_1905859 gocheck_do_not_annotate GO:0099629 biolink:CellularComponent postsynaptic specialization of symmetric synapse A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. go.json postsynaptic density of inhibitory synapse http://purl.obolibrary.org/obo/GO_0099629 goslim_synapse GO:0051680 biolink:BiologicalProcess 6-alpha-maltosylglucose biosynthetic process The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose. go.json isopanose biosynthesis|isopanose biosynthetic process http://purl.obolibrary.org/obo/GO_0051680 GO:0099627 biolink:BiologicalProcess neurotransmitter receptor cycle The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping). go.json http://purl.obolibrary.org/obo/GO_0099627 GO:0099628 biolink:BiologicalProcess neurotransmitter receptor diffusion trapping The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0099628 goslim_synapse GO:0099625 biolink:BiologicalProcess ventricular cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0099625 GO:0051683 biolink:BiologicalProcess establishment of Golgi localization The directed movement of the Golgi to a specific location. go.json establishment of Golgi apparatus localization|establishment of Golgi body localization|establishment of Golgi localisation http://purl.obolibrary.org/obo/GO_0051683 GO:0051684 biolink:BiologicalProcess maintenance of Golgi location Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of Golgi apparatus localization|maintenance of Golgi body localization|maintenance of Golgi localization http://purl.obolibrary.org/obo/GO_0051684 GO:0099626 biolink:MolecularActivity voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. go.json voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0099626 goslim_synapse GO:0051681 biolink:BiologicalProcess 6-alpha-maltosylglucose catabolic process The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose. go.json isopanose catabolic process|isopanose catabolism http://purl.obolibrary.org/obo/GO_0051681 GO:0099623 biolink:BiologicalProcess regulation of cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. go.json heart repolarization|regulation of cardiac muscle cell repolarization|regulation of cardiomyocyte membrane repolarization http://purl.obolibrary.org/obo/GO_0099623 GO:0051682 biolink:BiologicalProcess galactomannan catabolic process The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. go.json http://purl.obolibrary.org/obo/GO_0051682 GO:0099624 biolink:BiologicalProcess atrial cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0099624 GO:0002643 biolink:BiologicalProcess regulation of tolerance induction Any process that modulates the frequency, rate, or extent of tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0002643 GO:0051698 biolink:MolecularActivity saccharopine oxidase activity Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2. go.json SAX activity http://purl.obolibrary.org/obo/GO_0051698 GO:0002644 biolink:BiologicalProcess negative regulation of tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. go.json down regulation of tolerance induction|down-regulation of tolerance induction|downregulation of tolerance induction|inhibition of tolerance induction http://purl.obolibrary.org/obo/GO_0002644 GO:0051699 biolink:MolecularActivity obsolete proline oxidase activity OBSOLETE. Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2. go.json True http://purl.obolibrary.org/obo/GO_0051699 GO:0051696 biolink:BiologicalProcess pointed-end actin filament uncapping The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. go.json minus end F-actin uncapping|minus end actin filament uncapping|minus-end F-actin uncapping|minus-end actin filament uncapping|pointed end F-actin uncapping|pointed end actin filament uncapping|pointed-end F-actin uncapping http://purl.obolibrary.org/obo/GO_0051696 GO:0002645 biolink:BiologicalProcess positive regulation of tolerance induction Any process that activates or increases the frequency, rate, or extent of tolerance induction. go.json activation of tolerance induction|stimulation of tolerance induction|up regulation of tolerance induction|up-regulation of tolerance induction|upregulation of tolerance induction http://purl.obolibrary.org/obo/GO_0002645 GO:0051697 biolink:BiologicalProcess protein delipidation The breakage of covalent bonds to detach lipid groups from a protein. go.json http://purl.obolibrary.org/obo/GO_0051697 gocheck_do_not_annotate GO:0002646 biolink:BiologicalProcess regulation of central tolerance induction Any process that modulates the frequency, rate, or extent of central tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0002646 GO:0002640 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002640 GO:0002641 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002641 GO:0002642 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002642 GO:0061020 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061020 GO:1905870 biolink:BiologicalProcess positive regulation of 3'-UTR-mediated mRNA stabilization Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. go.json activation of 3'-UTR-mediated mRNA stabilization|activation of 3'-untranslated region-mediated mRNA stabilization|positive regulation of 3'-untranslated region-mediated mRNA stabilization|up regulation of 3'-UTR-mediated mRNA stabilization|up regulation of 3'-untranslated region-mediated mRNA stabilization|up-regulation of 3'-UTR-mediated mRNA stabilization|up-regulation of 3'-untranslated region-mediated mRNA stabilization|upregulation of 3'-UTR-mediated mRNA stabilization|upregulation of 3'-untranslated region-mediated mRNA stabilization http://purl.obolibrary.org/obo/GO_1905870 GO:0061021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061021 GO:1905871 biolink:BiologicalProcess regulation of protein localization to cell leading edge Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. go.json regulation of protein localisation in cell leading edge|regulation of protein localisation to cell leading edge|regulation of protein localization in cell leading edge http://purl.obolibrary.org/obo/GO_1905871 GO:0061022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061022 GO:1905872 biolink:BiologicalProcess negative regulation of protein localization to cell leading edge Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. go.json down regulation of protein localisation in cell leading edge|down regulation of protein localisation to cell leading edge|down regulation of protein localization in cell leading edge|down regulation of protein localization to cell leading edge|down-regulation of protein localisation in cell leading edge|down-regulation of protein localisation to cell leading edge|down-regulation of protein localization in cell leading edge|down-regulation of protein localization to cell leading edge|downregulation of protein localisation in cell leading edge|downregulation of protein localisation to cell leading edge|downregulation of protein localization in cell leading edge|downregulation of protein localization to cell leading edge|inhibition of protein localisation in cell leading edge|inhibition of protein localisation to cell leading edge|inhibition of protein localization in cell leading edge|inhibition of protein localization to cell leading edge|negative regulation of protein localisation in cell leading edge|negative regulation of protein localisation to cell leading edge|negative regulation of protein localization in cell leading edge http://purl.obolibrary.org/obo/GO_1905872 GO:0061023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061023 GO:0061024 biolink:BiologicalProcess membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. go.json cellular membrane organisation|cellular membrane organization|membrane organisation|membrane organization and biogenesis|single-organism membrane organization http://purl.obolibrary.org/obo/GO_0061024 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|prokaryote_subset GO:1905862 biolink:CellularComponent ferroxidase complex A protein complex which is capable of ferroxidase activity. go.json http://purl.obolibrary.org/obo/GO_1905862 GO:1905863 biolink:BiologicalProcess obsolete invadopodium organization OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an invadopodium. go.json True http://purl.obolibrary.org/obo/GO_1905863 GO:0061025 biolink:BiologicalProcess membrane fusion The membrane organization process that joins two lipid bilayers to form a single membrane. Wikipedia:Lipid_bilayer_fusion go.json cellular membrane fusion|single-organism membrane fusion http://purl.obolibrary.org/obo/GO_0061025 goslim_yeast GO:1905864 biolink:BiologicalProcess regulation of Atg1/ULK1 kinase complex assembly Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. go.json regulation of ATG1 kinase complex assembly|regulation of ATG1 kinase complex formation|regulation of ATG1-ATG13 complex assembly|regulation of ATG1-ATG13 complex formation|regulation of ATG1/ULK1 kinase complex formation|regulation of ATG1/ULK1 signaling complex assembly|regulation of ATG1/ULK1 signaling complex formation|regulation of Atg1p signalling complex assembly|regulation of Atg1p signalling complex formation|regulation of ULK1 signaling complex assembly|regulation of ULK1 signaling complex formation|regulation of ULK1-ATG13-FIP200 complex assembly|regulation of ULK1-ATG13-FIP200 complex formation|regulation of ULK1-ATG13-RB1CC1 complex assembly|regulation of ULK1-ATG13-RB1CC1 complex formation http://purl.obolibrary.org/obo/GO_1905864 GO:0061026 biolink:BiologicalProcess cardiac muscle tissue regeneration The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. go.json http://purl.obolibrary.org/obo/GO_0061026 GO:1905865 biolink:BiologicalProcess negative regulation of Atg1/ULK1 kinase complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. go.json down regulation of ATG1 kinase complex assembly|down regulation of ATG1 kinase complex formation|down regulation of ATG1-ATG13 complex assembly|down regulation of ATG1-ATG13 complex formation|down regulation of ATG1/ULK1 kinase complex assembly|down regulation of ATG1/ULK1 kinase complex formation|down regulation of ATG1/ULK1 signaling complex assembly|down regulation of ATG1/ULK1 signaling complex formation|down regulation of Atg1p signalling complex assembly|down regulation of Atg1p signalling complex formation|down regulation of ULK1 signaling complex assembly|down regulation of ULK1 signaling complex formation|down regulation of ULK1-ATG13-FIP200 complex assembly|down regulation of ULK1-ATG13-FIP200 complex formation|down regulation of ULK1-ATG13-RB1CC1 complex assembly|down regulation of ULK1-ATG13-RB1CC1 complex formation|down-regulation of ATG1 kinase complex assembly|down-regulation of ATG1 kinase complex formation|down-regulation of ATG1-ATG13 complex assembly|down-regulation of ATG1-ATG13 complex formation|down-regulation of ATG1/ULK1 kinase complex assembly|down-regulation of ATG1/ULK1 kinase complex formation|down-regulation of ATG1/ULK1 signaling complex assembly|down-regulation of ATG1/ULK1 signaling complex formation|down-regulation of Atg1p signalling complex assembly|down-regulation of Atg1p signalling complex formation|down-regulation of ULK1 signaling complex assembly|down-regulation of ULK1 signaling complex formation|down-regulation of ULK1-ATG13-FIP200 complex assembly|down-regulation of ULK1-ATG13-FIP200 complex formation|down-regulation of ULK1-ATG13-RB1CC1 complex assembly|down-regulation of ULK1-ATG13-RB1CC1 complex formation|downregulation of ATG1 kinase complex assembly|downregulation of ATG1 kinase complex formation|downregulation of ATG1-ATG13 complex assembly|downregulation of ATG1-ATG13 complex formation|downregulation of ATG1/ULK1 kinase complex assembly|downregulation of ATG1/ULK1 kinase complex formation|downregulation of ATG1/ULK1 signaling complex assembly|downregulation of ATG1/ULK1 signaling complex formation|downregulation of Atg1p signalling complex assembly|downregulation of Atg1p signalling complex formation|downregulation of ULK1 signaling complex assembly|downregulation of ULK1 signaling complex formation|downregulation of ULK1-ATG13-FIP200 complex assembly|downregulation of ULK1-ATG13-FIP200 complex formation|downregulation of ULK1-ATG13-RB1CC1 complex assembly|downregulation of ULK1-ATG13-RB1CC1 complex formation|inhibition of ATG1 kinase complex assembly|inhibition of ATG1 kinase complex formation|inhibition of ATG1-ATG13 complex assembly|inhibition of ATG1-ATG13 complex formation|inhibition of ATG1/ULK1 kinase complex assembly|inhibition of ATG1/ULK1 kinase complex formation|inhibition of ATG1/ULK1 signaling complex assembly|inhibition of ATG1/ULK1 signaling complex formation|inhibition of Atg1p signalling complex assembly|inhibition of Atg1p signalling complex formation|inhibition of ULK1 signaling complex assembly|inhibition of ULK1 signaling complex formation|inhibition of ULK1-ATG13-FIP200 complex assembly|inhibition of ULK1-ATG13-FIP200 complex formation|inhibition of ULK1-ATG13-RB1CC1 complex assembly|inhibition of ULK1-ATG13-RB1CC1 complex formation|negative regulation of ATG1 kinase complex assembly|negative regulation of ATG1 kinase complex formation|negative regulation of ATG1-ATG13 complex assembly|negative regulation of ATG1-ATG13 complex formation|negative regulation of ATG1/ULK1 kinase complex formation|negative regulation of ATG1/ULK1 signaling complex assembly|negative regulation of ATG1/ULK1 signaling complex formation|negative regulation of Atg1p signalling complex assembly|negative regulation of Atg1p signalling complex formation|negative regulation of ULK1 signaling complex assembly|negative regulation of ULK1 signaling complex formation|negative regulation of ULK1-ATG13-FIP200 complex assembly|negative regulation of ULK1-ATG13-FIP200 complex formation|negative regulation of ULK1-ATG13-RB1CC1 complex assembly|negative regulation of ULK1-ATG13-RB1CC1 complex formation http://purl.obolibrary.org/obo/GO_1905865 GO:0061027 biolink:BiologicalProcess umbilical cord development The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. go.json http://purl.obolibrary.org/obo/GO_0061027 GO:1905866 biolink:BiologicalProcess positive regulation of Atg1/ULK1 kinase complex assembly Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. go.json activation of ATG1 kinase complex assembly|activation of ATG1 kinase complex formation|activation of ATG1-ATG13 complex assembly|activation of ATG1-ATG13 complex formation|activation of ATG1/ULK1 kinase complex assembly|activation of ATG1/ULK1 kinase complex formation|activation of ATG1/ULK1 signaling complex assembly|activation of ATG1/ULK1 signaling complex formation|activation of Atg1p signalling complex assembly|activation of Atg1p signalling complex formation|activation of ULK1 signaling complex assembly|activation of ULK1 signaling complex formation|activation of ULK1-ATG13-FIP200 complex assembly|activation of ULK1-ATG13-FIP200 complex formation|activation of ULK1-ATG13-RB1CC1 complex assembly|activation of ULK1-ATG13-RB1CC1 complex formation|positive regulation of ATG1 kinase complex assembly|positive regulation of ATG1 kinase complex formation|positive regulation of ATG1-ATG13 complex assembly|positive regulation of ATG1-ATG13 complex formation|positive regulation of ATG1/ULK1 kinase complex formation|positive regulation of ATG1/ULK1 signaling complex assembly|positive regulation of ATG1/ULK1 signaling complex formation|positive regulation of Atg1p signalling complex assembly|positive regulation of Atg1p signalling complex formation|positive regulation of ULK1 signaling complex assembly|positive regulation of ULK1 signaling complex formation|positive regulation of ULK1-ATG13-FIP200 complex assembly|positive regulation of ULK1-ATG13-FIP200 complex formation|positive regulation of ULK1-ATG13-RB1CC1 complex assembly|positive regulation of ULK1-ATG13-RB1CC1 complex formation|up regulation of ATG1 kinase complex assembly|up regulation of ATG1 kinase complex formation|up regulation of ATG1-ATG13 complex assembly|up regulation of ATG1-ATG13 complex formation|up regulation of ATG1/ULK1 kinase complex assembly|up regulation of ATG1/ULK1 kinase complex formation|up regulation of ATG1/ULK1 signaling complex assembly|up regulation of ATG1/ULK1 signaling complex formation|up regulation of Atg1p signalling complex assembly|up regulation of Atg1p signalling complex formation|up regulation of ULK1 signaling complex assembly|up regulation of ULK1 signaling complex formation|up regulation of ULK1-ATG13-FIP200 complex assembly|up regulation of ULK1-ATG13-FIP200 complex formation|up regulation of ULK1-ATG13-RB1CC1 complex assembly|up regulation of ULK1-ATG13-RB1CC1 complex formation|up-regulation of ATG1 kinase complex assembly|up-regulation of ATG1 kinase complex formation|up-regulation of ATG1-ATG13 complex assembly|up-regulation of ATG1-ATG13 complex formation|up-regulation of ATG1/ULK1 kinase complex assembly|up-regulation of ATG1/ULK1 kinase complex formation|up-regulation of ATG1/ULK1 signaling complex assembly|up-regulation of ATG1/ULK1 signaling complex formation|up-regulation of Atg1p signalling complex assembly|up-regulation of Atg1p signalling complex formation|up-regulation of ULK1 signaling complex assembly|up-regulation of ULK1 signaling complex formation|up-regulation of ULK1-ATG13-FIP200 complex assembly|up-regulation of ULK1-ATG13-FIP200 complex formation|up-regulation of ULK1-ATG13-RB1CC1 complex assembly|up-regulation of ULK1-ATG13-RB1CC1 complex formation|upregulation of ATG1 kinase complex assembly|upregulation of ATG1 kinase complex formation|upregulation of ATG1-ATG13 complex assembly|upregulation of ATG1-ATG13 complex formation|upregulation of ATG1/ULK1 kinase complex assembly|upregulation of ATG1/ULK1 kinase complex formation|upregulation of ATG1/ULK1 signaling complex assembly|upregulation of ATG1/ULK1 signaling complex formation|upregulation of Atg1p signalling complex assembly|upregulation of Atg1p signalling complex formation|upregulation of ULK1 signaling complex assembly|upregulation of ULK1 signaling complex formation|upregulation of ULK1-ATG13-FIP200 complex assembly|upregulation of ULK1-ATG13-FIP200 complex formation|upregulation of ULK1-ATG13-RB1CC1 complex assembly|upregulation of ULK1-ATG13-RB1CC1 complex formation http://purl.obolibrary.org/obo/GO_1905866 GO:0061028 biolink:BiologicalProcess establishment of endothelial barrier The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. go.json http://purl.obolibrary.org/obo/GO_0061028 GO:1905867 biolink:BiologicalProcess epididymis development The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure. go.json epididymus development http://purl.obolibrary.org/obo/GO_1905867 GO:0061029 biolink:BiologicalProcess eyelid development in camera-type eye The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. go.json http://purl.obolibrary.org/obo/GO_0061029 GO:1905868 biolink:BiologicalProcess regulation of 3'-UTR-mediated mRNA stabilization Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. go.json regulation of 3'-untranslated region-mediated mRNA stabilization http://purl.obolibrary.org/obo/GO_1905868 GO:1905869 biolink:BiologicalProcess negative regulation of 3'-UTR-mediated mRNA stabilization Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. go.json down regulation of 3'-UTR-mediated mRNA stabilization|down regulation of 3'-untranslated region-mediated mRNA stabilization|down-regulation of 3'-UTR-mediated mRNA stabilization|down-regulation of 3'-untranslated region-mediated mRNA stabilization|downregulation of 3'-UTR-mediated mRNA stabilization|downregulation of 3'-untranslated region-mediated mRNA stabilization|inhibition of 3'-UTR-mediated mRNA stabilization|inhibition of 3'-untranslated region-mediated mRNA stabilization|negative regulation of 3'-untranslated region-mediated mRNA stabilization http://purl.obolibrary.org/obo/GO_1905869 GO:0051690 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051690 GO:0051691 biolink:BiologicalProcess obsolete cellular oligosaccharide metabolic process OBSOLETE. The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. go.json cellular oligosaccharide metabolism True http://purl.obolibrary.org/obo/GO_0051691 GO:0051694 biolink:BiologicalProcess pointed-end actin filament capping The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. go.json minus-end F-actin capping activity|minus-end actin filament capping activity|pointed-end F-actin capping activity|pointed-end actin capping activity http://purl.obolibrary.org/obo/GO_0051694 GO:0002647 biolink:BiologicalProcess negative regulation of central tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction. go.json down regulation of central tolerance induction|down-regulation of central tolerance induction|downregulation of central tolerance induction|inhibition of central tolerance induction http://purl.obolibrary.org/obo/GO_0002647 GO:0002648 biolink:BiologicalProcess positive regulation of central tolerance induction Any process that activates or increases the frequency, rate, or extent of central tolerance induction. go.json activation of central tolerance induction|stimulation of central tolerance induction|up regulation of central tolerance induction|up-regulation of central tolerance induction|upregulation of central tolerance induction http://purl.obolibrary.org/obo/GO_0002648 GO:0051695 biolink:BiologicalProcess actin filament uncapping The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. go.json F-actin uncapping http://purl.obolibrary.org/obo/GO_0051695 GO:0051692 biolink:BiologicalProcess obsolete cellular oligosaccharide catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. go.json cellular oligosaccharide breakdown|cellular oligosaccharide catabolism|cellular oligosaccharide degradation True http://purl.obolibrary.org/obo/GO_0051692 GO:0002649 biolink:BiologicalProcess regulation of tolerance induction to self antigen Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen. go.json http://purl.obolibrary.org/obo/GO_0002649 GO:0051693 biolink:BiologicalProcess actin filament capping The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. go.json F-actin capping activity|actin capping activity http://purl.obolibrary.org/obo/GO_0051693 GO:0002654 biolink:BiologicalProcess positive regulation of tolerance induction dependent upon immune response Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response. go.json activation of tolerance induction dependent upon immune response|positive regulation of immune response-dependent tolerance induction|stimulation of tolerance induction dependent upon immune response|up regulation of tolerance induction dependent upon immune response|up-regulation of tolerance induction dependent upon immune response|upregulation of tolerance induction dependent upon immune response http://purl.obolibrary.org/obo/GO_0002654 GO:0099600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099600 GO:0002655 biolink:BiologicalProcess regulation of tolerance induction to nonself antigen Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen. go.json http://purl.obolibrary.org/obo/GO_0002655 GO:0002656 biolink:BiologicalProcess negative regulation of tolerance induction to nonself antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen. go.json down regulation of tolerance induction to nonself antigen|down-regulation of tolerance induction to nonself antigen|downregulation of tolerance induction to nonself antigen|inhibition of tolerance induction to nonself antigen http://purl.obolibrary.org/obo/GO_0002656 GO:0002657 biolink:BiologicalProcess positive regulation of tolerance induction to nonself antigen Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen. go.json activation of tolerance induction to nonself antigen|stimulation of tolerance induction to nonself antigen|up regulation of tolerance induction to nonself antigen|up-regulation of tolerance induction to nonself antigen|upregulation of tolerance induction to nonself antigen http://purl.obolibrary.org/obo/GO_0002657 GO:0002650 biolink:BiologicalProcess negative regulation of tolerance induction to self antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen. go.json down regulation of tolerance induction to self antigen|down-regulation of tolerance induction to self antigen|downregulation of tolerance induction to self antigen|inhibition of tolerance induction to self antigen http://purl.obolibrary.org/obo/GO_0002650 GO:0002651 biolink:BiologicalProcess positive regulation of tolerance induction to self antigen Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen. go.json activation of tolerance induction to self antigen|stimulation of tolerance induction to self antigen|up regulation of tolerance induction to self antigen|up-regulation of tolerance induction to self antigen|upregulation of tolerance induction to self antigen http://purl.obolibrary.org/obo/GO_0002651 GO:0002652 biolink:BiologicalProcess regulation of tolerance induction dependent upon immune response Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response. go.json regulation of immune response-dependent tolerance induction http://purl.obolibrary.org/obo/GO_0002652 GO:0002653 biolink:BiologicalProcess negative regulation of tolerance induction dependent upon immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response. go.json down regulation of tolerance induction dependent upon immune response|down-regulation of tolerance induction dependent upon immune response|downregulation of tolerance induction dependent upon immune response|inhibition of tolerance induction dependent upon immune response|negative regulation of immune response-dependent tolerance induction http://purl.obolibrary.org/obo/GO_0002653 GO:1905880 biolink:BiologicalProcess negative regulation of oogenesis Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. go.json down regulation of oogenesis|down regulation of ovum development|down-regulation of oogenesis|down-regulation of ovum development|downregulation of oogenesis|downregulation of ovum development|inhibition of oogenesis|inhibition of ovum development|negative regulation of ovum development http://purl.obolibrary.org/obo/GO_1905880 GO:0061010 biolink:BiologicalProcess gallbladder development The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. go.json http://purl.obolibrary.org/obo/GO_0061010 GO:1905881 biolink:BiologicalProcess positive regulation of oogenesis Any process that activates or increases the frequency, rate or extent of oogenesis. go.json activation of oogenesis|activation of ovum development|positive regulation of ovum development|up regulation of oogenesis|up regulation of ovum development|up-regulation of oogenesis|up-regulation of ovum development|upregulation of oogenesis|upregulation of ovum development http://purl.obolibrary.org/obo/GO_1905881 GO:1905882 biolink:CellularComponent obsolete other organism cell wall OBSOLETE. Any cell wall that is part of a other organism. go.json True http://purl.obolibrary.org/obo/GO_1905882 GO:0061011 biolink:BiologicalProcess hepatic duct development The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. go.json http://purl.obolibrary.org/obo/GO_0061011 GO:1905883 biolink:BiologicalProcess regulation of triglyceride transport Any process that modulates the frequency, rate or extent of triglyceride transport. go.json regulation of triacylglycerol transport http://purl.obolibrary.org/obo/GO_1905883 GO:0061012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061012 GO:1905873 biolink:BiologicalProcess positive regulation of protein localization to cell leading edge Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. go.json activation of protein localisation in cell leading edge|activation of protein localisation to cell leading edge|activation of protein localization in cell leading edge|activation of protein localization to cell leading edge|positive regulation of protein localisation in cell leading edge|positive regulation of protein localisation to cell leading edge|positive regulation of protein localization in cell leading edge|up regulation of protein localisation in cell leading edge|up regulation of protein localisation to cell leading edge|up regulation of protein localization in cell leading edge|up regulation of protein localization to cell leading edge|up-regulation of protein localisation in cell leading edge|up-regulation of protein localisation to cell leading edge|up-regulation of protein localization in cell leading edge|up-regulation of protein localization to cell leading edge|upregulation of protein localisation in cell leading edge|upregulation of protein localisation to cell leading edge|upregulation of protein localization in cell leading edge|upregulation of protein localization to cell leading edge http://purl.obolibrary.org/obo/GO_1905873 GO:0061013 biolink:BiologicalProcess regulation of mRNA catabolic process Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. go.json regulation of mRNA decay http://purl.obolibrary.org/obo/GO_0061013 GO:1905874 biolink:BiologicalProcess regulation of postsynaptic density organization Any process that modulates the frequency, rate or extent of postsynaptic density organization. go.json regulation of PSD organization|regulation of post synaptic density organization|regulation of post-synaptic density organization|regulation of postsynaptic density organisation http://purl.obolibrary.org/obo/GO_1905874 GO:0061014 biolink:BiologicalProcess positive regulation of mRNA catabolic process Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. go.json positive regulation of mRNA decay http://purl.obolibrary.org/obo/GO_0061014 GO:1905875 biolink:BiologicalProcess negative regulation of postsynaptic density organization Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic density organization. go.json down regulation of PSD organization|down regulation of post synaptic density organization|down regulation of post-synaptic density organization|down regulation of postsynaptic density organisation|down regulation of postsynaptic density organization|down-regulation of PSD organization|down-regulation of post synaptic density organization|down-regulation of post-synaptic density organization|down-regulation of postsynaptic density organisation|down-regulation of postsynaptic density organization|downregulation of PSD organization|downregulation of post synaptic density organization|downregulation of post-synaptic density organization|downregulation of postsynaptic density organisation|downregulation of postsynaptic density organization|inhibition of PSD organization|inhibition of post synaptic density organization|inhibition of post-synaptic density organization|inhibition of postsynaptic density organisation|inhibition of postsynaptic density organization|negative regulation of PSD organization|negative regulation of post synaptic density organization|negative regulation of post-synaptic density organization|negative regulation of postsynaptic density organisation http://purl.obolibrary.org/obo/GO_1905875 GO:0061015 biolink:BiologicalProcess snRNA import into nucleus The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus. go.json http://purl.obolibrary.org/obo/GO_0061015 GO:1905876 biolink:BiologicalProcess positive regulation of postsynaptic density organization Any process that activates or increases the frequency, rate or extent of postsynaptic density organization. go.json activation of PSD organization|activation of post synaptic density organization|activation of post-synaptic density organization|activation of postsynaptic density organisation|activation of postsynaptic density organization|positive regulation of PSD organization|positive regulation of post synaptic density organization|positive regulation of post-synaptic density organization|positive regulation of postsynaptic density organisation|up regulation of PSD organization|up regulation of post synaptic density organization|up regulation of post-synaptic density organization|up regulation of postsynaptic density organisation|up regulation of postsynaptic density organization|up-regulation of PSD organization|up-regulation of post synaptic density organization|up-regulation of post-synaptic density organization|up-regulation of postsynaptic density organisation|up-regulation of postsynaptic density organization|upregulation of PSD organization|upregulation of post synaptic density organization|upregulation of post-synaptic density organization|upregulation of postsynaptic density organisation|upregulation of postsynaptic density organization http://purl.obolibrary.org/obo/GO_1905876 GO:0061016 biolink:BiologicalProcess snRNA localization to Cajal body The directed movement of snRNA, small nuclear ribonucleic acid, to a Cajal body. go.json http://purl.obolibrary.org/obo/GO_0061016 GO:0061017 biolink:BiologicalProcess hepatoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. go.json http://purl.obolibrary.org/obo/GO_0061017 GO:1905877 biolink:BiologicalProcess obsolete invadopodium assembly OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form an invadopodium. go.json invadopodium formation True http://purl.obolibrary.org/obo/GO_1905877 GO:0061018 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061018 GO:1905878 biolink:BiologicalProcess obsolete invadopodium disassembly OBSOLETE. The disaggregation of an invadopodium into its constituent components. go.json True http://purl.obolibrary.org/obo/GO_1905878 GO:0061019 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061019 GO:1905879 biolink:BiologicalProcess regulation of oogenesis Any process that modulates the frequency, rate or extent of oogenesis. go.json regulation of ovum development http://purl.obolibrary.org/obo/GO_1905879 GO:0099609 biolink:MolecularActivity microtubule lateral binding Binding to the side of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0099609 GO:0099607 biolink:BiologicalProcess lateral attachment of mitotic spindle microtubules to kinetochore The cellular process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate). go.json http://purl.obolibrary.org/obo/GO_0099607 GO:0099608 biolink:BiologicalProcess regulation of action potential firing pattern Any process that regulates the temporal pattern of a sequence of action potentials in a neuron. go.json spike train sculpting http://purl.obolibrary.org/obo/GO_0099608 GO:0099605 biolink:BiologicalProcess regulation of action potential firing rate Any process that regulates the frequency of action potentials in a spike train. go.json http://purl.obolibrary.org/obo/GO_0099605 GO:0099606 biolink:BiologicalProcess microtubule plus-end directed mitotic chromosome migration The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression. go.json plus-end directed chromosome gliding http://purl.obolibrary.org/obo/GO_0099606 GO:0099603 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099603 GO:0002658 biolink:BiologicalProcess regulation of peripheral tolerance induction Any process that modulates the frequency, rate, or extent of peripheral tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0002658 GO:0002659 biolink:BiologicalProcess negative regulation of peripheral tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction. go.json down regulation of peripheral tolerance induction|down-regulation of peripheral tolerance induction|downregulation of peripheral tolerance induction|inhibition of peripheral tolerance induction http://purl.obolibrary.org/obo/GO_0002659 GO:0099604 biolink:MolecularActivity ligand-gated calcium channel activity Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0099604 GO:0099601 biolink:BiologicalProcess regulation of neurotransmitter receptor activity Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. go.json http://purl.obolibrary.org/obo/GO_0099601 gocheck_do_not_annotate|goslim_synapse GO:0099602 biolink:MolecularActivity neurotransmitter receptor regulator activity A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing. go.json http://purl.obolibrary.org/obo/GO_0099602 GO:0036080 biolink:MolecularActivity purine nucleotide-sugar transmembrane transporter activity Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json http://purl.obolibrary.org/obo/GO_0036080 GO:0036081 biolink:MolecularActivity extracellular ammonia-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts. go.json extracellular ammonia-gated ion channel activity|ionotropic ammonia receptor activity http://purl.obolibrary.org/obo/GO_0036081 GO:0036079 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036079 GO:0036071 biolink:BiologicalProcess N-glycan fucosylation The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains. go.json glycoprotein fucosylation http://purl.obolibrary.org/obo/GO_0036071 GO:0036072 biolink:BiologicalProcess direct ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. go.json http://purl.obolibrary.org/obo/GO_0036072 GO:0036073 biolink:BiologicalProcess perichondral ossification Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage. go.json http://purl.obolibrary.org/obo/GO_0036073 GO:0036074 biolink:BiologicalProcess metaplastic ossification Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division. go.json metaplasia http://purl.obolibrary.org/obo/GO_0036074 GO:0036075 biolink:BiologicalProcess replacement ossification Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. go.json indirect ossification http://purl.obolibrary.org/obo/GO_0036075 GO:0036076 biolink:BiologicalProcess ligamentous ossification Ossification wherein bone tissue forms within ligamentous tissue. go.json http://purl.obolibrary.org/obo/GO_0036076 GO:0036077 biolink:BiologicalProcess intratendonous ossification Ossification wherein bone tissue forms within tendonous tissue. go.json http://purl.obolibrary.org/obo/GO_0036077 GO:0036078 biolink:BiologicalProcess minus-end specific microtubule depolymerization The removal of tubulin heterodimers from the minus end of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0036078 GO:0036070 biolink:BiologicalProcess light-independent bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants. go.json light independent bacteriochlorophyll biosynthetic process|light-independent bacteriochlorophyll anabolism|light-independent bacteriochlorophyll biosynthesis|light-independent bacteriochlorophyll formation|light-independent bacteriochlorophyll synthesis http://purl.obolibrary.org/obo/GO_0036070 GO:0036068 biolink:BiologicalProcess light-independent chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light. go.json light independent chlorophyll biosynthetic process|light-independent chlorophyll anabolism|light-independent chlorophyll biosynthesis|light-independent chlorophyll formation|light-independent chlorophyll synthesis http://purl.obolibrary.org/obo/GO_0036068 GO:0036069 biolink:BiologicalProcess light-dependent bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants. go.json light dependent bacteriochlorophyll biosynthetic process|light-dependent bacteriochlorophyll anabolism|light-dependent bacteriochlorophyll biosynthesis|light-dependent bacteriochlorophyll formation|light-dependent bacteriochlorophyll synthesis http://purl.obolibrary.org/obo/GO_0036069 GO:0036060 biolink:BiologicalProcess slit diaphragm assembly The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. go.json http://purl.obolibrary.org/obo/GO_0036060 GO:0036061 biolink:BiologicalProcess muscle cell chemotaxis toward tendon cell The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells. go.json muscle cell attraction|muscle cell chemotaxis towards tendon cell http://purl.obolibrary.org/obo/GO_0036061 GO:0036062 biolink:CellularComponent presynaptic periactive zone A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development. go.json periactive zone|pre-synaptic periactive zone http://purl.obolibrary.org/obo/GO_0036062 GO:0036063 biolink:CellularComponent acroblast A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle. go.json spermatid acroblast http://purl.obolibrary.org/obo/GO_0036063 GO:0036064 biolink:CellularComponent ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. NIF_Subcellular:sao11978067 go.json basal body|cilial basal body|cilium basal body|kinetosome|microtubule basal body http://purl.obolibrary.org/obo/GO_0036064 GO:0036065 biolink:BiologicalProcess fucosylation The covalent attachment of a fucosyl group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0036065 GO:0036066 biolink:BiologicalProcess protein O-linked fucosylation The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. go.json http://purl.obolibrary.org/obo/GO_0036066 GO:0036067 biolink:BiologicalProcess light-dependent chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light. go.json light dependent chlorophyll biosynthetic process|light-dependent chlorophyll anabolism|light-dependent chlorophyll biosynthesis|light-dependent chlorophyll formation|light-dependent chlorophyll synthesis http://purl.obolibrary.org/obo/GO_0036067 GO:0036057 biolink:CellularComponent slit diaphragm A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. go.json http://purl.obolibrary.org/obo/GO_0036057 GO:0036058 biolink:BiologicalProcess filtration diaphragm assembly The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph. go.json http://purl.obolibrary.org/obo/GO_0036058 GO:0036059 biolink:BiologicalProcess nephrocyte diaphragm assembly The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney. go.json http://purl.obolibrary.org/obo/GO_0036059 GO:0036050 biolink:BiologicalProcess peptidyl-lysine succinylation The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine. RESID:AA0545 go.json http://purl.obolibrary.org/obo/GO_0036050 gocheck_do_not_annotate GO:0036051 biolink:BiologicalProcess protein localization to trailing edge A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement. go.json protein localisation to trailing edge http://purl.obolibrary.org/obo/GO_0036051 GO:0036052 biolink:BiologicalProcess protein localization to uropod A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell. go.json protein localisation to uropod http://purl.obolibrary.org/obo/GO_0036052 GO:0036053 biolink:CellularComponent glomerular endothelium fenestra A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes. go.json GEnC fenestration|glomerular endothelial cell fenestration http://purl.obolibrary.org/obo/GO_0036053 GO:0036054 biolink:MolecularActivity protein-malonyllysine demalonylase activity Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide. go.json peptidyl-malonyllysine demalonylase activity|protein lysine demalonylation activity|protein malonyl lysine demalonylation activity http://purl.obolibrary.org/obo/GO_0036054 GO:0036055 biolink:MolecularActivity protein-succinyllysine desuccinylase activity Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:47668 go.json peptidyl-succinyllysine desuccinylase activity|succinyl lysine desuccinylase activity|succinyllysine desuccinylase activity http://purl.obolibrary.org/obo/GO_0036055 GO:0036056 biolink:CellularComponent filtration diaphragm A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph. go.json http://purl.obolibrary.org/obo/GO_0036056 GO:0036046 biolink:BiologicalProcess protein demalonylation The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide. go.json http://purl.obolibrary.org/obo/GO_0036046 gocheck_do_not_annotate GO:0036047 biolink:BiologicalProcess peptidyl-lysine demalonylation The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0036047 gocheck_do_not_annotate GO:0036048 biolink:BiologicalProcess protein desuccinylation The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0036048 gocheck_do_not_annotate GO:0036049 biolink:BiologicalProcess peptidyl-lysine desuccinylation The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0036049 gocheck_do_not_annotate GO:0036040 biolink:BiologicalProcess curcumin catabolic process The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin. go.json (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown|(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process|(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism|(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation|curcumin breakdown|curcumin catabolism|curcumin degradation|diferuloylmethane breakdown|diferuloylmethane catabolic process|diferuloylmethane catabolism|diferuloylmethane degradation|turmeric yellow breakdown|turmeric yellow catabolic process|turmeric yellow catabolism|turmeric yellow degradation http://purl.obolibrary.org/obo/GO_0036040 GO:0036041 biolink:MolecularActivity long-chain fatty acid binding Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json long chain fatty acid binding http://purl.obolibrary.org/obo/GO_0036041 GO:0036042 biolink:MolecularActivity long-chain fatty acyl-CoA binding Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json long-chain fatty acyl-coenyme A binding http://purl.obolibrary.org/obo/GO_0036042 GO:0036043 biolink:CellularComponent obsolete microspike OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell. go.json microspike True http://purl.obolibrary.org/obo/GO_0036043 GO:0036044 biolink:BiologicalProcess obsolete protein malonylation OBSOLETE. The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group. go.json protein malonylation True http://purl.obolibrary.org/obo/GO_0036044 GO:0036045 biolink:BiologicalProcess obsolete peptidyl-lysine malonylation OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine. go.json lysine malonylation|peptidyl-lysine malonylation True http://purl.obolibrary.org/obo/GO_0036045 GO:0036035 biolink:BiologicalProcess osteoclast development The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. go.json osteoclast cell development http://purl.obolibrary.org/obo/GO_0036035 GO:0036036 biolink:BiologicalProcess cardiac neural crest cell delamination The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube. go.json http://purl.obolibrary.org/obo/GO_0036036 GO:0036037 biolink:BiologicalProcess CD8-positive, alpha-beta T cell activation The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json http://purl.obolibrary.org/obo/GO_0036037 GO:0036038 biolink:CellularComponent MKS complex A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. go.json B9 complex|MKS module|TCTN-B9D complex|tectonic complex|tectonic-like complex http://purl.obolibrary.org/obo/GO_0036038 GO:0036039 biolink:BiologicalProcess curcumin metabolic process The chemical reactions and pathways involving the polyphenol, curcumin. go.json (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolic process|(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolism|curcumin metabolism|diferuloylmethane metabolic process|diferuloylmethane metabolism|turmeric yellow metabolic process|turmeric yellow metabolism http://purl.obolibrary.org/obo/GO_0036039 GO:0036030 biolink:CellularComponent protein C inhibitor-plasma kallikrein complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein. go.json PCI-plasma kallikrein complex|SERPINA5-plasma kallikrein complex|plasma serine protease inhibitor-plasma kallikrein complex|protein C inhibitor-KLKB1 complex|serpin A5-plasma kallikrein complex http://purl.obolibrary.org/obo/GO_0036030 GO:0036031 biolink:BiologicalProcess recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript. go.json capping enzyme targeting to RNA polymerase II|recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex http://purl.obolibrary.org/obo/GO_0036031 GO:0036032 biolink:BiologicalProcess neural crest cell delamination The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube. go.json neural crest cell emigration|neural crest cell individualization|neural crest cell segregation http://purl.obolibrary.org/obo/GO_0036032 GO:0036033 biolink:MolecularActivity mediator complex binding Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. go.json http://purl.obolibrary.org/obo/GO_0036033 GO:0036034 biolink:BiologicalProcess mediator complex assembly The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. go.json http://purl.obolibrary.org/obo/GO_0036034 GO:0051600 biolink:BiologicalProcess regulation of endocytosis by exocyst localization Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. go.json regulation of endocytosis by exocyst localisation|regulation of site selection of endocytosis|relocation of endocytosis|spatial regulation of endocytosis http://purl.obolibrary.org/obo/GO_0051600 GO:0051603 biolink:BiologicalProcess proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. go.json peptidolysis during cellular protein catabolic process|peptidolysis during cellular protein catabolism|peptidolysis involved in cellular protein catabolic process|peptidolysis involved in cellular protein catabolism|proteolysis during cellular protein catabolic process|proteolysis during cellular protein catabolism|proteolysis involved in cellular protein catabolic process http://purl.obolibrary.org/obo/GO_0051603 goslim_yeast GO:0051604 biolink:BiologicalProcess protein maturation Any process leading to the attainment of the full functional capacity of a protein. go.json http://purl.obolibrary.org/obo/GO_0051604 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast|prokaryote_subset GO:0051601 biolink:BiologicalProcess exocyst localization Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. go.json establishment and maintenance of exocyst localization|exocyst localisation http://purl.obolibrary.org/obo/GO_0051601 GO:0051602 biolink:BiologicalProcess response to electrical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. go.json response to electricity http://purl.obolibrary.org/obo/GO_0051602 GO:0051607 biolink:BiologicalProcess defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism. go.json antiviral response|defence response to virus|defense response to viruses http://purl.obolibrary.org/obo/GO_0051607 GO:0051608 biolink:BiologicalProcess histamine transport The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json http://purl.obolibrary.org/obo/GO_0051608 GO:0051605 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051605 GO:0051606 biolink:BiologicalProcess detection of stimulus The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. go.json perception of stimulus|stimulus detection|stimulus sensing http://purl.obolibrary.org/obo/GO_0051606 goslim_pir GO:0051609 biolink:BiologicalProcess inhibition of neurotransmitter uptake Any process that prevents the activation of the directed movement of a neurotransmitter into a cell. go.json inhibition of neurotransmitter import http://purl.obolibrary.org/obo/GO_0051609 GO:0036024 biolink:CellularComponent protein C inhibitor-TMPRSS7 complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7. go.json PCI-TMPRSS7 complex|SERPINA5-TMPRSS7 complex|plasma serine protease inhibitor-TMPRSS7 complex|protein C inhibitor-matriptase-3 complex|protein C inhibitor-transmembrane protease serine 7 complex|serpin A5-TMPRSS7 complex http://purl.obolibrary.org/obo/GO_0036024 GO:0036025 biolink:CellularComponent protein C inhibitor-TMPRSS11E complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E. go.json PCI-TMPRSS11E complex|SERPINA5-TMPRSS11E complex|plasma serine protease inhibitor-TMPRSS11E complex|protein C inhibitor-transmembrane protease serine 11E complex|serpin A5-TMPRSS11E complex http://purl.obolibrary.org/obo/GO_0036025 GO:0036026 biolink:CellularComponent protein C inhibitor-PLAT complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator. go.json PCI-PLAT complex|SERPINA5-PLAT complex|plasma serine protease inhibitor-PLAT complex|protein C inhibitor-tPA complex|protein C inhibitor-tissue-type plasminogen activator complex|serpin A5-PLAT complex http://purl.obolibrary.org/obo/GO_0036026 GO:0036027 biolink:CellularComponent protein C inhibitor-PLAU complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator. go.json PCI-PLAU complex|SERPINA5-PLAU complex|plasma serine protease inhibitor-PLAU complex|protein C inhibitor-U-plasminogen activator complex|protein C inhibitor-uPA complex|protein C inhibitor-urokinase-type plasminogen activator complex|serpin A5-PLAU complex http://purl.obolibrary.org/obo/GO_0036027 GO:0036028 biolink:CellularComponent protein C inhibitor-thrombin complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin. go.json PCI-thrombin complex|SERPINA5-thrombin complex|plasma serine protease inhibitor-thrombin complex|protein C inhibitor-F2 complex|protein C inhibitor-coagulation factor II complex|serpin A5-thrombin complex http://purl.obolibrary.org/obo/GO_0036028 GO:0036029 biolink:CellularComponent protein C inhibitor-KLK3 complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen. go.json PCI-KLK3 complex|SERPINA5-KLK3 complex|plasma serine protease inhibitor-KLK3 complex|protein C inhibitor-kallikrein-3 complex|protein C inhibitor-prostate-specific antigen complex|serpin A5-KLK3 complex http://purl.obolibrary.org/obo/GO_0036029 GO:0036020 biolink:CellularComponent endolysosome membrane The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. go.json endolysosomal membrane http://purl.obolibrary.org/obo/GO_0036020 GO:0036021 biolink:CellularComponent endolysosome lumen The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. go.json endolysosomal lumen http://purl.obolibrary.org/obo/GO_0036021 GO:0036022 biolink:BiologicalProcess limb joint morphogenesis The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner. go.json knee morphogenesis|leg joint morphogenesis http://purl.obolibrary.org/obo/GO_0036022 GO:0036023 biolink:BiologicalProcess embryonic skeletal limb joint morphogenesis The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb. go.json http://purl.obolibrary.org/obo/GO_0036023 GO:0051610 biolink:BiologicalProcess serotonin uptake The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. go.json 5-HT uptake|5-hydroxytryptamine uptake|5HT uptake|serotonin import http://purl.obolibrary.org/obo/GO_0051610 GO:0051611 biolink:BiologicalProcess regulation of serotonin uptake Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell. go.json regulation of 5-HT uptake|regulation of 5-hydroxytryptamine uptake|regulation of 5HT uptake|regulation of serotonin import http://purl.obolibrary.org/obo/GO_0051611 GO:0051614 biolink:BiologicalProcess inhibition of serotonin uptake Any process that prevents the activation of the directed movement of serotonin into a cell. go.json inhibition of 5-HT uptake|inhibition of 5-hydroxytryptamine uptake|inhibition of 5HT uptake|inhibition of serotonin import http://purl.obolibrary.org/obo/GO_0051614 GO:0051615 biolink:BiologicalProcess histamine uptake The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json histamine import http://purl.obolibrary.org/obo/GO_0051615 GO:0051612 biolink:BiologicalProcess negative regulation of serotonin uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. go.json down regulation of serotonin uptake|down-regulation of serotonin uptake|downregulation of serotonin uptake|negative regulation of 5-HT uptake|negative regulation of 5-hydroxytryptamine uptake|negative regulation of 5HT uptake|negative regulation of serotonin import http://purl.obolibrary.org/obo/GO_0051612 GO:0051613 biolink:BiologicalProcess positive regulation of serotonin uptake Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell. go.json activation of serotonin uptake|positive regulation of 5-HT uptake|positive regulation of 5-hydroxytryptamine uptake|positive regulation of 5HT uptake|positive regulation of serotonin import|stimulation of serotonin uptake|up regulation of serotonin uptake|up-regulation of serotonin uptake|upregulation of serotonin uptake http://purl.obolibrary.org/obo/GO_0051613 GO:0051618 biolink:BiologicalProcess positive regulation of histamine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell. go.json activation of histamine uptake|positive regulation of histamine import|stimulation of histamine uptake|up regulation of histamine uptake|up-regulation of histamine uptake|upregulation of histamine uptake http://purl.obolibrary.org/obo/GO_0051618 GO:0051619 biolink:BiologicalProcess inhibition of histamine uptake Any process that prevents the activation of the directed movement of histamine into a cell. go.json inhibition of histamine import http://purl.obolibrary.org/obo/GO_0051619 GO:0051616 biolink:BiologicalProcess regulation of histamine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell. go.json regulation of histamine import http://purl.obolibrary.org/obo/GO_0051616 GO:0051617 biolink:BiologicalProcess negative regulation of histamine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell. go.json down regulation of histamine uptake|down-regulation of histamine uptake|downregulation of histamine uptake|negative regulation of histamine import http://purl.obolibrary.org/obo/GO_0051617 GO:0036013 biolink:CellularComponent cyanelle outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope. go.json http://purl.obolibrary.org/obo/GO_0036013 GO:0036014 biolink:CellularComponent cyanelle intermembrane space The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer. go.json cyanelle envelope lumen|cyanelle periplasm http://purl.obolibrary.org/obo/GO_0036014 GO:0036015 biolink:BiologicalProcess response to interleukin-3 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. go.json response to IL-3 http://purl.obolibrary.org/obo/GO_0036015 GO:0036016 biolink:BiologicalProcess cellular response to interleukin-3 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. go.json cellular response to IL-3 http://purl.obolibrary.org/obo/GO_0036016 GO:0036017 biolink:BiologicalProcess response to erythropoietin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis. go.json http://purl.obolibrary.org/obo/GO_0036017 GO:0036018 biolink:BiologicalProcess cellular response to erythropoietin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. go.json http://purl.obolibrary.org/obo/GO_0036018 GO:0036019 biolink:CellularComponent endolysosome An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. go.json http://purl.obolibrary.org/obo/GO_0036019 GO:0036010 biolink:BiologicalProcess protein localization to endosome A process in which a protein is transported to, or maintained in, a location within an endosome. go.json protein localisation in endosome|protein localization in endosome http://purl.obolibrary.org/obo/GO_0036010 GO:0036011 biolink:BiologicalProcess imaginal disc-derived leg segmentation Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint. go.json http://purl.obolibrary.org/obo/GO_0036011 GO:0036012 biolink:CellularComponent cyanelle inner membrane The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma. go.json cyanelle inner envelope membrane http://purl.obolibrary.org/obo/GO_0036012 GO:0051621 biolink:BiologicalProcess regulation of norepinephrine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. go.json regulation of levarterenol uptake|regulation of noradrenaline uptake|regulation of norepinephrine import http://purl.obolibrary.org/obo/GO_0051621 GO:0051622 biolink:BiologicalProcess negative regulation of norepinephrine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. go.json down regulation of norepinephrine uptake|down-regulation of norepinephrine uptake|downregulation of norepinephrine uptake|negative regulation of levarterenol uptake|negative regulation of noradrenaline uptake|negative regulation of norepinephrine import http://purl.obolibrary.org/obo/GO_0051622 GO:0051620 biolink:BiologicalProcess norepinephrine uptake The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. go.json levarterenol reuptake|levarterenol uptake|noradrenaline reuptake|noradrenaline uptake|norepinephrine import|norepinephrine reuptake http://purl.obolibrary.org/obo/GO_0051620 GO:0051625 biolink:BiologicalProcess epinephrine uptake The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. go.json adrenaline reuptake|adrenaline uptake|epinephrine import|epinephrine reuptake http://purl.obolibrary.org/obo/GO_0051625 GO:0051626 biolink:BiologicalProcess regulation of epinephrine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell. go.json regulation of adrenaline uptake|regulation of epinephrine import http://purl.obolibrary.org/obo/GO_0051626 GO:0051623 biolink:BiologicalProcess positive regulation of norepinephrine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. go.json activation of norepinephrine uptake|positive regulation of levarterenol uptake|positive regulation of noradrenaline uptake|positive regulation of norepinephrine import|stimulation of norepinephrine uptake|up regulation of norepinephrine uptake|up-regulation of norepinephrine uptake|upregulation of norepinephrine uptake http://purl.obolibrary.org/obo/GO_0051623 GO:0051624 biolink:BiologicalProcess inhibition of norepinephrine uptake Any process that prevents the activation of the directed movement of norepinephrine into a cell. go.json inhibition of levarterenol uptake|inhibition of noradrenaline uptake|inhibition of norepinephrine import http://purl.obolibrary.org/obo/GO_0051624 GO:0051629 biolink:BiologicalProcess inhibition of epinephrine uptake Any process that prevents the activation of the directed movement of epinephrine into a cell. go.json inhibition of adrenaline uptake|inhibition of epinephrine import http://purl.obolibrary.org/obo/GO_0051629 GO:0051627 biolink:BiologicalProcess negative regulation of epinephrine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell. go.json down regulation of epinephrine uptake|down-regulation of epinephrine uptake|downregulation of epinephrine uptake|negative regulation of adrenaline uptake|negative regulation of epinephrine import http://purl.obolibrary.org/obo/GO_0051627 GO:0051628 biolink:BiologicalProcess positive regulation of epinephrine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell. go.json activation of epinephrine uptake|positive regulation of adrenaline uptake|positive regulation of epinephrine import|stimulation of epinephrine uptake|up regulation of epinephrine uptake|up-regulation of epinephrine uptake|upregulation of epinephrine uptake http://purl.obolibrary.org/obo/GO_0051628 GO:0036002 biolink:MolecularActivity pre-mRNA binding Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. go.json protein-coding primary transcript binding http://purl.obolibrary.org/obo/GO_0036002 GO:0036003 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0036003 GO:0036004 biolink:MolecularActivity GAF domain binding Binding to a GAF protein domain. go.json http://purl.obolibrary.org/obo/GO_0036004 GO:0036005 biolink:BiologicalProcess response to macrophage colony-stimulating factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. go.json response to M-CSF|response to macrophage colony-stimulating factor stimulus http://purl.obolibrary.org/obo/GO_0036005 GO:0036006 biolink:BiologicalProcess cellular response to macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. go.json cellular response to M-CSF stimulus|cellular response to macrophage colony-stimulating factor http://purl.obolibrary.org/obo/GO_0036006 GO:0036007 biolink:CellularComponent scintillon A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen. go.json http://purl.obolibrary.org/obo/GO_0036007 GO:0036008 biolink:BiologicalProcess sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate. MetaCyc:SUCUTIL-PWY go.json http://purl.obolibrary.org/obo/GO_0036008 GO:0036009 biolink:MolecularActivity protein-glutamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine. Reactome:R-HSA-6800138 go.json protein glutamine N-methylase activity|protein glutamine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0036009 GO:0036000 biolink:CellularComponent mucocyst A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion. go.json http://purl.obolibrary.org/obo/GO_0036000 GO:0036001 biolink:BiologicalProcess 'de novo' pyridoxal 5'-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components. MetaCyc:PYRIDOXSYN-PWY go.json 'de novo' PLP biosynthesis|'de novo' pyridoxal 5'-phosphate anabolism|'de novo' pyridoxal 5'-phosphate biosynthesis|'de novo' pyridoxal 5'-phosphate formation|'de novo' pyridoxal 5'-phosphate synthesis|'de novo' pyridoxal phosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0036001 GO:0120057 biolink:BiologicalProcess regulation of small intestinal transit Any process that modulates the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. go.json regulation of small bowel transit|regulation of small intestine transit http://purl.obolibrary.org/obo/GO_0120057 GO:0120058 biolink:BiologicalProcess positive regulation of small intestinal transit Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. go.json positive regulation of small bowel transit|positive regulation of small intestine transit http://purl.obolibrary.org/obo/GO_0120058 GO:0120059 biolink:BiologicalProcess negative regulation of small intestinal transit Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. go.json negative regulation of small bowel transit|negative regulation of small intestine transit http://purl.obolibrary.org/obo/GO_0120059 GO:0120053 biolink:MolecularActivity ribitol beta-1,4-xylosyltransferase activity Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R. go.json http://purl.obolibrary.org/obo/GO_0120053 GO:0120054 biolink:BiologicalProcess intestinal motility Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth). go.json http://purl.obolibrary.org/obo/GO_0120054 GO:0120055 biolink:BiologicalProcess small intestinal transit Migration of ingested material along the length of the small intestine. go.json small bowel transit|small intestine transit http://purl.obolibrary.org/obo/GO_0120055 GO:0120056 biolink:BiologicalProcess large intestinal transit Migration of ingested material along the length of the large intestine. go.json colon transit|colonic transit|large bowel transit|large intestine transit http://purl.obolibrary.org/obo/GO_0120056 GO:0120068 biolink:BiologicalProcess regulation of stomach fundus smooth muscle contraction Any process that modulates the frequency, rate or extent of any stomach fundus smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0120068 GO:0120069 biolink:BiologicalProcess positive regulation of stomach fundus smooth muscle contraction Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0120069 GO:0120064 biolink:BiologicalProcess stomach pylorus smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach. go.json http://purl.obolibrary.org/obo/GO_0120064 GO:0120065 biolink:BiologicalProcess pyloric antrum smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach. go.json antrum smooth muscle contraction http://purl.obolibrary.org/obo/GO_0120065 GO:0120066 biolink:BiologicalProcess pyloric canal smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter. go.json http://purl.obolibrary.org/obo/GO_0120066 GO:0120067 biolink:BiologicalProcess pyloric sphincter smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum. go.json http://purl.obolibrary.org/obo/GO_0120067 GO:0120060 biolink:BiologicalProcess regulation of gastric emptying Any process that modulates the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. go.json regulation of small bowel emptying|regulation of small intestine emptying http://purl.obolibrary.org/obo/GO_0120060 GO:0120061 biolink:BiologicalProcess negative regulation of gastric emptying Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. go.json http://purl.obolibrary.org/obo/GO_0120061 GO:0120062 biolink:BiologicalProcess positive regulation of gastric emptying Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. go.json http://purl.obolibrary.org/obo/GO_0120062 GO:0120063 biolink:BiologicalProcess stomach smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach. go.json http://purl.obolibrary.org/obo/GO_0120063 GO:0120079 biolink:BiologicalProcess obsolete regulation of microfilament motor activity OBSOLETE. Any process that modulates the frequency, rate or extent of microfilament motor activity. go.json regulation of actin filament motor activity|regulation of actin-activated ATPase activity|regulation of actin-dependent ATPase activity|regulation of actin-filament motor activity|regulation of muscle motor activity|regulation of myosin ATPase activity True http://purl.obolibrary.org/obo/GO_0120079 GO:0120075 biolink:BiologicalProcess positive regulation of endocardial cushion cell differentiation Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0120075 GO:0120076 biolink:BiologicalProcess negative regulation of endocardial cushion cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0120076 GO:0120077 biolink:BiologicalProcess angiogenic sprout fusion The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis. go.json blood vessel anastomosis http://purl.obolibrary.org/obo/GO_0120077 GO:0120078 biolink:BiologicalProcess cell adhesion involved in sprouting angiogenesis The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network. go.json cell adhesion involved in blood vessel anastomosis|cell adhesion involved in vascular anastomosis http://purl.obolibrary.org/obo/GO_0120078 GO:0120071 biolink:BiologicalProcess regulation of pyloric antrum smooth muscle contraction Any process that modulates the frequency, rate or extent of any pyloric antrum smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0120071 GO:0120072 biolink:BiologicalProcess positive regulation of pyloric antrum smooth muscle contraction Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0120072 GO:0120073 biolink:BiologicalProcess negative regulation of pyloric antrum smooth muscle contraction Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0120073 GO:0120074 biolink:BiologicalProcess regulation of endocardial cushion cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell. go.json http://purl.obolibrary.org/obo/GO_0120074 GO:0120070 biolink:BiologicalProcess negative regulation of stomach fundus smooth muscle contraction Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0120070 GO:0120086 biolink:MolecularActivity (3S)-(+)-asterisca-2(9),6-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene. go.json asterisca-2(9),6-diene synthase activity http://purl.obolibrary.org/obo/GO_0120086 GO:0120082 biolink:CellularComponent smooth endoplasmic reticulum cisterna A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity. go.json http://purl.obolibrary.org/obo/GO_0120082 GO:0120083 biolink:CellularComponent rough endoplasmic reticulum cisterna A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity. go.json http://purl.obolibrary.org/obo/GO_0120083 GO:0120084 biolink:BiologicalProcess endothelial tip cell filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout. go.json http://purl.obolibrary.org/obo/GO_0120084 GO:0120085 biolink:BiologicalProcess obsolete transposon integration involved in RNA-mediated transposition OBSOLETE. Any transposon integration that contributes to a process of RNA-mediated transposition. go.json retrotransposon integration True http://purl.obolibrary.org/obo/GO_0120085 GO:0120080 biolink:BiologicalProcess obsolete negative regulation of microfilament motor activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of microfilament motor activity. go.json down regulation of actin-activated ATPase activity|down regulation of actin-dependent ATPase activity|inhibition of actin-activated ATPase activity|inhibition of actin-dependent ATPase activity|negative regulation of actin filament motor activity|negative regulation of actin-activated ATPase activity|negative regulation of actin-dependent ATPase activity|negative regulation of actin-filament motor activity|negative regulation of muscle motor activity|negative regulation of myosin ATPase activity True http://purl.obolibrary.org/obo/GO_0120080 GO:0120081 biolink:BiologicalProcess obsolete positive regulation of microfilament motor activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of microfilament motor activity. go.json activation of actin-activated ATPase activity|activation of actin-dependent ATPase activity|positive regulation of actin filament motor activity|positive regulation of actin-activated ATPase activity|positive regulation of actin-dependent ATPase activity|positive regulation of actin-filament motor activity|positive regulation of muscle motor activity|positive regulation of myosin ATPase activity|upregulation of actin-dependent ATPase activity True http://purl.obolibrary.org/obo/GO_0120081 GO:0120017 biolink:MolecularActivity ceramide transfer activity Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json ceramide carrier activity|ceramide transporter activity|intermembrane ceramide transfer activity http://purl.obolibrary.org/obo/GO_0120017 GO:0120018 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0120018 GO:0120019 biolink:MolecularActivity phosphatidylcholine transfer activity Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json intermembrane phosphatidylcholine transfer activity|phosphatidylcholine carrier activity http://purl.obolibrary.org/obo/GO_0120019 GO:0120013 biolink:MolecularActivity lipid transfer activity Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. go.json intermembrane lipid transfer activity|lipid carrier activity http://purl.obolibrary.org/obo/GO_0120013 GO:0120014 biolink:MolecularActivity phospholipid transfer activity Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json intermembrane phospholipid transfer activity|phospholipid carrier activity http://purl.obolibrary.org/obo/GO_0120014 GO:0120015 biolink:MolecularActivity sterol transfer activity Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json intermembrane sterol transfer activity|sterol carrier activity http://purl.obolibrary.org/obo/GO_0120015 GO:0120016 biolink:MolecularActivity sphingolipid transfer activity Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json intermembrane sphingolipid transfer activity|sphingolipid carrier activity http://purl.obolibrary.org/obo/GO_0120016 GO:0120010 biolink:BiologicalProcess intermembrane phospholipid transfer The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. go.json http://purl.obolibrary.org/obo/GO_0120010 GO:0120011 biolink:BiologicalProcess intermembrane sterol transfer The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). go.json http://purl.obolibrary.org/obo/GO_0120011 GO:0120012 biolink:BiologicalProcess intermembrane sphingolipid transfer The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). go.json http://purl.obolibrary.org/obo/GO_0120012 GO:0120028 biolink:BiologicalProcess negative regulation of osmosensory signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120028 GO:0120029 biolink:BiologicalProcess proton export across plasma membrane The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region. go.json hydrogen ion export across plasma membrane|hydrogen ion export from cell|proton export from cell http://purl.obolibrary.org/obo/GO_0120029 GO:0120024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0120024 GO:0120025 biolink:CellularComponent plasma membrane bounded cell projection A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. go.json http://purl.obolibrary.org/obo/GO_0120025 GO:0120026 biolink:CellularComponent host cell uropod A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. go.json host cell uropodium http://purl.obolibrary.org/obo/GO_0120026 GO:0120027 biolink:BiologicalProcess regulation of osmosensory signaling pathway Any process that modulates the frequency, rate or extent of osmosensory signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120027 GO:0120020 biolink:MolecularActivity cholesterol transfer activity Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Reactome:R-HSA-1454928|Reactome:R-HSA-216723|Reactome:R-HSA-265443|Reactome:R-HSA-265545|Reactome:R-HSA-266082|Reactome:R-HSA-5682111|Reactome:R-HSA-8951850 go.json cholesterol carrier activity|cholesterol transporter activity|intermembrane cholesterol transfer activity http://purl.obolibrary.org/obo/GO_0120020 GO:0120021 biolink:MolecularActivity oxysterol transfer activity Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json intermembrane oxysterol transfer activity|oxysterol carrier activity http://purl.obolibrary.org/obo/GO_0120021 GO:0120022 biolink:MolecularActivity glucagon family peptide binding Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP). go.json glucagon binding|glucagon-like peptide binding http://purl.obolibrary.org/obo/GO_0120022 GO:0120023 biolink:MolecularActivity somatostatin binding Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin. go.json http://purl.obolibrary.org/obo/GO_0120023 GO:0120039 biolink:BiologicalProcess plasma membrane bounded cell projection morphogenesis The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0120039 GO:0120035 biolink:BiologicalProcess regulation of plasma membrane bounded cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. go.json http://purl.obolibrary.org/obo/GO_0120035 GO:0120036 biolink:BiologicalProcess plasma membrane bounded cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. go.json http://purl.obolibrary.org/obo/GO_0120036 GO:0120038 biolink:CellularComponent obsolete plasma membrane bounded cell projection part OBSOLETE. Any constituent part of a plasma membrane bounded cell projection, a prolongation or process extending from a cell, e.g. a cilium or axon. go.json True http://purl.obolibrary.org/obo/GO_0120038 GO:0120031 biolink:BiologicalProcess plasma membrane bounded cell projection assembly Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. go.json eupodium http://purl.obolibrary.org/obo/GO_0120031 GO:0120032 biolink:BiologicalProcess regulation of plasma membrane bounded cell projection assembly Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. go.json http://purl.obolibrary.org/obo/GO_0120032 GO:0120033 biolink:BiologicalProcess negative regulation of plasma membrane bounded cell projection assembly Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. go.json http://purl.obolibrary.org/obo/GO_0120033 GO:0120034 biolink:BiologicalProcess positive regulation of plasma membrane bounded cell projection assembly Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. go.json http://purl.obolibrary.org/obo/GO_0120034 GO:0120030 biolink:BiologicalProcess positive regulation of cilium beat frequency involved in ciliary motility Any process that activates or increases the frequency of cilium beating involved in ciliary motility. go.json http://purl.obolibrary.org/obo/GO_0120030 GO:0120046 biolink:BiologicalProcess regulation of protein localization to medial cortical node Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node. go.json http://purl.obolibrary.org/obo/GO_0120046 GO:0120047 biolink:BiologicalProcess positive regulation of protein localization to medial cortical node Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node. go.json http://purl.obolibrary.org/obo/GO_0120047 GO:0120048 biolink:MolecularActivity U6 snRNA (adenine-(43)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA. go.json http://purl.obolibrary.org/obo/GO_0120048 GO:0120049 biolink:BiologicalProcess snRNA (adenine-N6)-methylation The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0120049 GO:0120042 biolink:BiologicalProcess negative regulation of macrophage proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation. go.json http://purl.obolibrary.org/obo/GO_0120042 GO:0120043 biolink:CellularComponent stereocilium shaft The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle. go.json http://purl.obolibrary.org/obo/GO_0120043 GO:0120044 biolink:CellularComponent stereocilium base The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium. go.json stereocilium taper http://purl.obolibrary.org/obo/GO_0120044 GO:0120045 biolink:BiologicalProcess stereocilium maintenance The organization process that preserves a stereocilium in a stable functional or structural state. go.json http://purl.obolibrary.org/obo/GO_0120045 GO:0120040 biolink:BiologicalProcess regulation of macrophage proliferation Any process that modulates the frequency, rate or extent of macrophage proliferation. go.json http://purl.obolibrary.org/obo/GO_0120040 GO:0120041 biolink:BiologicalProcess positive regulation of macrophage proliferation Any process that activates or increases the frequency, rate or extent of macrophage proliferation. go.json http://purl.obolibrary.org/obo/GO_0120041 GO:0002863 biolink:BiologicalProcess positive regulation of inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. go.json activation of inflammatory response to antigenic stimulus|stimulation of inflammatory response to antigenic stimulus|up regulation of inflammatory response to antigenic stimulus|up-regulation of inflammatory response to antigenic stimulus|upregulation of inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002863 GO:0002864 biolink:BiologicalProcess regulation of acute inflammatory response to antigenic stimulus Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. go.json http://purl.obolibrary.org/obo/GO_0002864 GO:0002865 biolink:BiologicalProcess negative regulation of acute inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. go.json down regulation of acute inflammatory response to antigenic stimulus|down-regulation of acute inflammatory response to antigenic stimulus|downregulation of acute inflammatory response to antigenic stimulus|inhibition of acute inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002865 GO:0002866 biolink:BiologicalProcess positive regulation of acute inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. go.json activation of acute inflammatory response to antigenic stimulus|stimulation of acute inflammatory response to antigenic stimulus|up regulation of acute inflammatory response to antigenic stimulus|up-regulation of acute inflammatory response to antigenic stimulus|upregulation of acute inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002866 GO:0002860 biolink:BiologicalProcess positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. go.json activation of natural killer cell mediated cytotoxicity directed against tumor cell target|stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target|up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target http://purl.obolibrary.org/obo/GO_0002860 GO:0002861 biolink:BiologicalProcess regulation of inflammatory response to antigenic stimulus Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. go.json http://purl.obolibrary.org/obo/GO_0002861 GO:0002862 biolink:BiologicalProcess negative regulation of inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. go.json down regulation of inflammatory response to antigenic stimulus|down-regulation of inflammatory response to antigenic stimulus|downregulation of inflammatory response to antigenic stimulus|inhibition of inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002862 GO:0061160 biolink:BiologicalProcess regulation of establishment of bipolar cell polarity regulating cell shape Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell. go.json http://purl.obolibrary.org/obo/GO_0061160 GO:0061161 biolink:BiologicalProcess positive regulation of establishment of bipolar cell polarity regulating cell shape Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell. go.json http://purl.obolibrary.org/obo/GO_0061161 GO:0061162 biolink:BiologicalProcess establishment of monopolar cell polarity The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. go.json http://purl.obolibrary.org/obo/GO_0061162 GO:0061163 biolink:BiologicalProcess endoplasmic reticulum polarization The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. Endoplasmic reticulum polarization serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. go.json ER localization involved in ER polarization at cell division site|ER polarization|endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site|endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site|establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site|establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site|maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site|transitional endoplasmic reticulum polarization at cell division site http://purl.obolibrary.org/obo/GO_0061163 GO:0061164 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061164 GO:0061165 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061165 GO:0061166 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061166 GO:0061167 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061167 GO:0061168 biolink:BiologicalProcess regulation of hair follicle placode formation Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. go.json http://purl.obolibrary.org/obo/GO_0061168 GO:0061169 biolink:BiologicalProcess positive regulation of hair placode formation Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. go.json http://purl.obolibrary.org/obo/GO_0061169 GO:0002867 biolink:BiologicalProcess regulation of B cell deletion Any process that modulates the frequency, rate, or extent of B cell deletion. go.json regulation of B lymphocyte deletion|regulation of B-cell deletion|regulation of B-lymphocyte deletion http://purl.obolibrary.org/obo/GO_0002867 GO:0002868 biolink:BiologicalProcess negative regulation of B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion. go.json down regulation of B cell deletion|down-regulation of B cell deletion|downregulation of B cell deletion|inhibition of B cell deletion|negative regulation of B lymphocyte deletion|negative regulation of B-cell deletion|negative regulation of B-lymphocyte deletion http://purl.obolibrary.org/obo/GO_0002868 GO:0002869 biolink:BiologicalProcess positive regulation of B cell deletion Any process that activates or increases the frequency, rate, or extent of B cell deletion. go.json activation of B cell deletion|positive regulation of B lymphocyte deletion|positive regulation of B-cell deletion|positive regulation of B-lymphocyte deletion|stimulation of B cell deletion|up regulation of B cell deletion|up-regulation of B cell deletion|upregulation of B cell deletion http://purl.obolibrary.org/obo/GO_0002869 GO:0002874 biolink:BiologicalProcess regulation of chronic inflammatory response to antigenic stimulus Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. go.json http://purl.obolibrary.org/obo/GO_0002874 GO:0002875 biolink:BiologicalProcess negative regulation of chronic inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. go.json down regulation of chronic inflammatory response to antigenic stimulus|down-regulation of chronic inflammatory response to antigenic stimulus|downregulation of chronic inflammatory response to antigenic stimulus|inhibition of chronic inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002875 GO:0002876 biolink:BiologicalProcess positive regulation of chronic inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. go.json activation of chronic inflammatory response to antigenic stimulus|stimulation of chronic inflammatory response to antigenic stimulus|up regulation of chronic inflammatory response to antigenic stimulus|up-regulation of chronic inflammatory response to antigenic stimulus|upregulation of chronic inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002876 GO:0002877 biolink:BiologicalProcess regulation of acute inflammatory response to non-antigenic stimulus Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. go.json http://purl.obolibrary.org/obo/GO_0002877 GO:0002870 biolink:BiologicalProcess T cell anergy Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction. go.json T lymphocyte anergy|T-cell anergy|T-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002870 GO:0002871 biolink:BiologicalProcess regulation of natural killer cell tolerance induction Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction. go.json regulation of NK cell tolerance induction http://purl.obolibrary.org/obo/GO_0002871 GO:0002872 biolink:BiologicalProcess negative regulation of natural killer cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction. go.json down regulation of natural killer cell tolerance induction|down-regulation of natural killer cell tolerance induction|downregulation of natural killer cell tolerance induction|inhibition of natural killer cell tolerance induction|negative regulation of NK cell tolerance induction http://purl.obolibrary.org/obo/GO_0002872 GO:0002873 biolink:BiologicalProcess positive regulation of natural killer cell tolerance induction Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction. go.json activation of natural killer cell tolerance induction|positive regulation of NK cell tolerance induction|stimulation of natural killer cell tolerance induction|up regulation of natural killer cell tolerance induction|up-regulation of natural killer cell tolerance induction|upregulation of natural killer cell tolerance induction http://purl.obolibrary.org/obo/GO_0002873 GO:0061150 biolink:BiologicalProcess renal system segmentation The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis. go.json urinary tract segmentation http://purl.obolibrary.org/obo/GO_0061150 GO:0061151 biolink:BiologicalProcess obsolete BMP signaling pathway involved in renal system segmentation OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the segmentation of the renal system. go.json BMP signalling pathway involved in renal system segmentation True http://purl.obolibrary.org/obo/GO_0061151 GO:0061152 biolink:BiologicalProcess trachea submucosa development The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. go.json http://purl.obolibrary.org/obo/GO_0061152 GO:0061153 biolink:BiologicalProcess trachea gland development The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. go.json http://purl.obolibrary.org/obo/GO_0061153 GO:0061154 biolink:BiologicalProcess endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. go.json http://purl.obolibrary.org/obo/GO_0061154 GO:0061155 biolink:BiologicalProcess pulmonary artery endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. go.json http://purl.obolibrary.org/obo/GO_0061155 GO:0061156 biolink:BiologicalProcess pulmonary artery morphogenesis The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. go.json http://purl.obolibrary.org/obo/GO_0061156 GO:0061157 biolink:BiologicalProcess mRNA destabilization Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. go.json http://purl.obolibrary.org/obo/GO_0061157 GO:0061158 biolink:BiologicalProcess 3'-UTR-mediated mRNA destabilization An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. go.json http://purl.obolibrary.org/obo/GO_0061158 GO:0061159 biolink:BiologicalProcess establishment of bipolar cell polarity involved in cell morphogenesis The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane. go.json http://purl.obolibrary.org/obo/GO_0061159 GO:0002878 biolink:BiologicalProcess negative regulation of acute inflammatory response to non-antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. go.json down regulation of acute inflammatory response to non-antigenic stimulus|down-regulation of acute inflammatory response to non-antigenic stimulus|downregulation of acute inflammatory response to non-antigenic stimulus|inhibition of acute inflammatory response to non-antigenic stimulus http://purl.obolibrary.org/obo/GO_0002878 GO:0002879 biolink:BiologicalProcess positive regulation of acute inflammatory response to non-antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. go.json activation of acute inflammatory response to non-antigenic stimulus|stimulation of acute inflammatory response to non-antigenic stimulus|up regulation of acute inflammatory response to non-antigenic stimulus|up-regulation of acute inflammatory response to non-antigenic stimulus|upregulation of acute inflammatory response to non-antigenic stimulus http://purl.obolibrary.org/obo/GO_0002879 GO:0002841 biolink:BiologicalProcess negative regulation of T cell mediated immune response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell. go.json down regulation of T cell mediated immune response to tumor cell|down-regulation of T cell mediated immune response to tumor cell|downregulation of T cell mediated immune response to tumor cell|inhibition of T cell mediated immune response to tumor cell|negative regulation of T cell mediated immune response to tumour cell|negative regulation of T lymphocyte mediated immune response to tumor cell|negative regulation of T-cell mediated immune response to tumor cell|negative regulation of T-lymphocyte mediated immune response to tumor cell http://purl.obolibrary.org/obo/GO_0002841 GO:0002842 biolink:BiologicalProcess positive regulation of T cell mediated immune response to tumor cell Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell. go.json activation of T cell mediated immune response to tumor cell|positive regulation of T cell mediated immune response to tumour cell|positive regulation of T lymphocyte mediated immune response to tumor cell|positive regulation of T-cell mediated immune response to tumor cell|positive regulation of T-lymphocyte mediated immune response to tumor cell|stimulation of T cell mediated immune response to tumor cell|up regulation of T cell mediated immune response to tumor cell|up-regulation of T cell mediated immune response to tumor cell|upregulation of T cell mediated immune response to tumor cell http://purl.obolibrary.org/obo/GO_0002842 GO:0002843 biolink:BiologicalProcess regulation of tolerance induction to tumor cell Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell. go.json regulation of tolerance induction to tumour cell http://purl.obolibrary.org/obo/GO_0002843 GO:0002844 biolink:BiologicalProcess negative regulation of tolerance induction to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell. go.json down regulation of tolerance induction to tumor cell|down-regulation of tolerance induction to tumor cell|downregulation of tolerance induction to tumor cell|inhibition of tolerance induction to tumor cell|negative regulation of tolerance induction to tumour cell http://purl.obolibrary.org/obo/GO_0002844 GO:0002840 biolink:BiologicalProcess regulation of T cell mediated immune response to tumor cell Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell. go.json regulation of T cell mediated immune response to tumour cell|regulation of T lymphocyte mediated immune response to tumor cell|regulation of T-cell mediated immune response to tumor cell|regulation of T-lymphocyte mediated immune response to tumor cell http://purl.obolibrary.org/obo/GO_0002840 GO:0061180 biolink:BiologicalProcess mammary gland epithelium development The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. go.json breast epithelium development http://purl.obolibrary.org/obo/GO_0061180 GO:0061181 biolink:BiologicalProcess regulation of chondrocyte development Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. go.json http://purl.obolibrary.org/obo/GO_0061181 GO:0061182 biolink:BiologicalProcess negative regulation of chondrocyte development Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. go.json http://purl.obolibrary.org/obo/GO_0061182 GO:0061183 biolink:BiologicalProcess regulation of dermatome development Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. go.json http://purl.obolibrary.org/obo/GO_0061183 GO:0061184 biolink:BiologicalProcess positive regulation of dermatome development Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. go.json http://purl.obolibrary.org/obo/GO_0061184 GO:0061185 biolink:BiologicalProcess negative regulation of dermatome development Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. go.json http://purl.obolibrary.org/obo/GO_0061185 GO:0061186 biolink:BiologicalProcess negative regulation of silent mating-type cassette heterochromatin formation Any process that decreases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette. go.json negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of silent mating-type cassette heterochromatin assembly http://purl.obolibrary.org/obo/GO_0061186 GO:0061187 biolink:BiologicalProcess regulation of rDNA heterochromatin formation Any process that modulates the rate, frequency, or extent of rDNA heterochromatin formation. go.json regulation of chromatin silencing at rDNA|regulation of ribosomal DNA heterochromatin assembly http://purl.obolibrary.org/obo/GO_0061187 GO:0061188 biolink:BiologicalProcess negative regulation of rDNA heterochromatin formation Any process that decreases the rate, frequency, or extent of ribosomal DNA heterochromatin formation. go.json negative regulation of chromatin silencing at rDNA|negative regulation of ribosomal DNA heterochromatin assembly|negative regulation of ribosomal DNA heterochromatin formation http://purl.obolibrary.org/obo/GO_0061188 GO:0061189 biolink:BiologicalProcess positive regulation of sclerotome development Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. go.json http://purl.obolibrary.org/obo/GO_0061189 GO:0002849 biolink:BiologicalProcess regulation of peripheral T cell tolerance induction Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0002849 GO:0002845 biolink:BiologicalProcess positive regulation of tolerance induction to tumor cell Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell. go.json activation of tolerance induction to tumor cell|positive regulation of tolerance induction to tumour cell|stimulation of tolerance induction to tumor cell|up regulation of tolerance induction to tumor cell|up-regulation of tolerance induction to tumor cell|upregulation of tolerance induction to tumor cell http://purl.obolibrary.org/obo/GO_0002845 GO:0002846 biolink:BiologicalProcess regulation of T cell tolerance induction to tumor cell Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell. go.json http://purl.obolibrary.org/obo/GO_0002846 GO:0002847 biolink:BiologicalProcess negative regulation of T cell tolerance induction to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell. go.json down regulation of T cell tolerance induction to tumor cell|down-regulation of T cell tolerance induction to tumor cell|downregulation of T cell tolerance induction to tumor cell|inhibition of T cell tolerance induction to tumor cell http://purl.obolibrary.org/obo/GO_0002847 GO:0002848 biolink:BiologicalProcess positive regulation of T cell tolerance induction to tumor cell Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell. go.json activation of T cell tolerance induction to tumor cell|stimulation of T cell tolerance induction to tumor cell|up regulation of T cell tolerance induction to tumor cell|up-regulation of T cell tolerance induction to tumor cell|upregulation of T cell tolerance induction to tumor cell http://purl.obolibrary.org/obo/GO_0002848 GO:0002852 biolink:BiologicalProcess regulation of T cell mediated cytotoxicity directed against tumor cell target Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. go.json http://purl.obolibrary.org/obo/GO_0002852 GO:0002853 biolink:BiologicalProcess negative regulation of T cell mediated cytotoxicity directed against tumor cell target Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. go.json down regulation of T cell mediated cytotoxicity directed against tumor cell target|down-regulation of T cell mediated cytotoxicity directed against tumor cell target|downregulation of T cell mediated cytotoxicity directed against tumor cell target|inhibition of T cell mediated cytotoxicity directed against tumor cell target http://purl.obolibrary.org/obo/GO_0002853 GO:0002854 biolink:BiologicalProcess positive regulation of T cell mediated cytotoxicity directed against tumor cell target Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. go.json activation of T cell mediated cytotoxicity directed against tumor cell target|stimulation of T cell mediated cytotoxicity directed against tumor cell target|up regulation of T cell mediated cytotoxicity directed against tumor cell target|up-regulation of T cell mediated cytotoxicity directed against tumor cell target|upregulation of T cell mediated cytotoxicity directed against tumor cell target http://purl.obolibrary.org/obo/GO_0002854 GO:0002855 biolink:BiologicalProcess regulation of natural killer cell mediated immune response to tumor cell Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. go.json http://purl.obolibrary.org/obo/GO_0002855 GO:0002850 biolink:BiologicalProcess negative regulation of peripheral T cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction. go.json down regulation of peripheral T cell tolerance induction|down-regulation of peripheral T cell tolerance induction|downregulation of peripheral T cell tolerance induction|inhibition of peripheral T cell tolerance induction http://purl.obolibrary.org/obo/GO_0002850 GO:0002851 biolink:BiologicalProcess positive regulation of peripheral T cell tolerance induction Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction. go.json activation of peripheral T cell tolerance induction|stimulation of peripheral T cell tolerance induction|up regulation of peripheral T cell tolerance induction|up-regulation of peripheral T cell tolerance induction|upregulation of peripheral T cell tolerance induction http://purl.obolibrary.org/obo/GO_0002851 GO:0061170 biolink:BiologicalProcess negative regulation of hair follicle placode formation Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. go.json http://purl.obolibrary.org/obo/GO_0061170 GO:0061171 biolink:BiologicalProcess establishment of bipolar cell polarity The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane. go.json http://purl.obolibrary.org/obo/GO_0061171 GO:0061172 biolink:BiologicalProcess regulation of establishment of bipolar cell polarity Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane. go.json http://purl.obolibrary.org/obo/GO_0061172 GO:0061173 biolink:BiologicalProcess positive regulation of establishment of bipolar cell polarity Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity. go.json http://purl.obolibrary.org/obo/GO_0061173 GO:0061174 biolink:CellularComponent type I terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. go.json type I terminal button http://purl.obolibrary.org/obo/GO_0061174 GO:0061175 biolink:CellularComponent type II terminal bouton Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. go.json type II terminal button http://purl.obolibrary.org/obo/GO_0061175 GO:0061176 biolink:CellularComponent type Ib terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons. go.json type Ib terminal button http://purl.obolibrary.org/obo/GO_0061176 GO:0061177 biolink:CellularComponent type Is terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons. go.json type Is terminal button http://purl.obolibrary.org/obo/GO_0061177 GO:0061178 biolink:BiologicalProcess regulation of insulin secretion involved in cellular response to glucose stimulus Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. go.json regulation of insulin secretion in response to glucose http://purl.obolibrary.org/obo/GO_0061178 GO:0061179 biolink:BiologicalProcess negative regulation of insulin secretion involved in cellular response to glucose stimulus Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. go.json negative regulation of insulin secretion in response to glucose|negative regulation of insulin secretion involved in cellular response to glucose http://purl.obolibrary.org/obo/GO_0061179 GO:0002856 biolink:BiologicalProcess negative regulation of natural killer cell mediated immune response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. go.json down regulation of natural killer cell mediated immune response to tumor cell|down-regulation of natural killer cell mediated immune response to tumor cell|downregulation of natural killer cell mediated immune response to tumor cell|inhibition of natural killer cell mediated immune response to tumor cell http://purl.obolibrary.org/obo/GO_0002856 GO:0002857 biolink:BiologicalProcess positive regulation of natural killer cell mediated immune response to tumor cell Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. go.json activation of natural killer cell mediated immune response to tumor cell|stimulation of natural killer cell mediated immune response to tumor cell|up regulation of natural killer cell mediated immune response to tumor cell|up-regulation of natural killer cell mediated immune response to tumor cell|upregulation of natural killer cell mediated immune response to tumor cell http://purl.obolibrary.org/obo/GO_0002857 GO:0002858 biolink:BiologicalProcess regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. go.json http://purl.obolibrary.org/obo/GO_0002858 GO:0002859 biolink:BiologicalProcess negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. go.json down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target|inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target http://purl.obolibrary.org/obo/GO_0002859 GO:0002820 biolink:BiologicalProcess negative regulation of adaptive immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. go.json down regulation of adaptive immune response|down-regulation of adaptive immune response|downregulation of adaptive immune response|inhibition of adaptive immune response http://purl.obolibrary.org/obo/GO_0002820 GO:0002821 biolink:BiologicalProcess positive regulation of adaptive immune response Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. go.json activation of adaptive immune response|stimulation of adaptive immune response|up regulation of adaptive immune response|up-regulation of adaptive immune response|upregulation of adaptive immune response http://purl.obolibrary.org/obo/GO_0002821 GO:0002822 biolink:BiologicalProcess regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. go.json http://purl.obolibrary.org/obo/GO_0002822 GO:0120097 biolink:CellularComponent glycosylphosphatidylinositol-mannosyltransferase II complex A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p. go.json GPI-MT-I complex http://purl.obolibrary.org/obo/GO_0120097 GO:0120098 biolink:CellularComponent procentriole A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primative land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells. go.json http://purl.obolibrary.org/obo/GO_0120098 GO:0120099 biolink:CellularComponent procentriole replication complex A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates. go.json http://purl.obolibrary.org/obo/GO_0120099 GO:0120093 biolink:BiologicalProcess regulation of peptidyl-lysine crotonylation Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0120093 GO:0002827 biolink:BiologicalProcess positive regulation of T-helper 1 type immune response Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. go.json activation of T-helper 1 type immune response|stimulation of T-helper 1 type immune response|up regulation of T-helper 1 type immune response|up-regulation of T-helper 1 type immune response|upregulation of T-helper 1 type immune response http://purl.obolibrary.org/obo/GO_0002827 GO:0120094 biolink:BiologicalProcess negative regulation of peptidyl-lysine crotonylation Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0120094 GO:0002828 biolink:BiologicalProcess regulation of type 2 immune response Any process that modulates the frequency, rate, or extent of a type 2 immune response. go.json regulation of T-helper 2 type immune response|regulation of Th2 immune response http://purl.obolibrary.org/obo/GO_0002828 GO:0002829 biolink:BiologicalProcess negative regulation of type 2 immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. go.json down regulation of type 2 immune response|down-regulation of type 2 immune response|downregulation of type 2 immune response|inhibition of type 2 immune response|negative regulation of T-helper 2 type immune response|negative regulation of Th2 immune response http://purl.obolibrary.org/obo/GO_0002829 GO:0120095 biolink:CellularComponent vacuole-isolation membrane contact site An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome. go.json VICS|vacuole-IM contact site|vacuole-phagophore contact site http://purl.obolibrary.org/obo/GO_0120095 GO:0002823 biolink:BiologicalProcess negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. go.json http://purl.obolibrary.org/obo/GO_0002823 GO:0002824 biolink:BiologicalProcess positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. go.json http://purl.obolibrary.org/obo/GO_0002824 GO:0120091 biolink:MolecularActivity jasmonic acid hydrolase Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid. go.json 2-oxoglutarate dioxygenase http://purl.obolibrary.org/obo/GO_0120091 GO:0002825 biolink:BiologicalProcess regulation of T-helper 1 type immune response Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. go.json http://purl.obolibrary.org/obo/GO_0002825 GO:0120092 biolink:MolecularActivity crotonyl-CoA hydratase activity Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. RHEA:45584 go.json http://purl.obolibrary.org/obo/GO_0120092 GO:0002826 biolink:BiologicalProcess negative regulation of T-helper 1 type immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. go.json down regulation of T-helper 1 type immune response|down-regulation of T-helper 1 type immune response|downregulation of T-helper 1 type immune response|inhibition of T-helper 1 type immune response http://purl.obolibrary.org/obo/GO_0002826 GO:0002830 biolink:BiologicalProcess positive regulation of type 2 immune response Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. go.json activation of type 2 immune response|positive regulation of T-helper 2 type immune response|positive regulation of Th2 immune response|stimulation of type 2 immune response|up regulation of type 2 immune response|up-regulation of type 2 immune response|upregulation of type 2 immune response http://purl.obolibrary.org/obo/GO_0002830 GO:0002831 biolink:BiologicalProcess regulation of response to biotic stimulus Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. go.json http://purl.obolibrary.org/obo/GO_0002831 gocheck_do_not_manually_annotate GO:0002832 biolink:BiologicalProcess negative regulation of response to biotic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. go.json down regulation of response to biotic stimulus|down-regulation of response to biotic stimulus|downregulation of response to biotic stimulus|inhibition of response to biotic stimulus http://purl.obolibrary.org/obo/GO_0002832 gocheck_do_not_manually_annotate GO:0002833 biolink:BiologicalProcess positive regulation of response to biotic stimulus Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. go.json activation of response to biotic stimulus|stimulation of response to biotic stimulus|up regulation of response to biotic stimulus|up-regulation of response to biotic stimulus|upregulation of response to biotic stimulus http://purl.obolibrary.org/obo/GO_0002833 gocheck_do_not_manually_annotate GO:0061190 biolink:BiologicalProcess regulation of sclerotome development Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. go.json http://purl.obolibrary.org/obo/GO_0061190 GO:0061191 biolink:BiologicalProcess positive regulation of vacuole fusion, non-autophagic Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. go.json http://purl.obolibrary.org/obo/GO_0061191 GO:0061192 biolink:BiologicalProcess negative regulation of vacuole fusion, non-autophagic Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. go.json http://purl.obolibrary.org/obo/GO_0061192 GO:0061193 biolink:BiologicalProcess taste bud development The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors. go.json http://purl.obolibrary.org/obo/GO_0061193 GO:0061194 biolink:BiologicalProcess taste bud morphogenesis The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors. go.json http://purl.obolibrary.org/obo/GO_0061194 GO:0061195 biolink:BiologicalProcess taste bud formation The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors. go.json http://purl.obolibrary.org/obo/GO_0061195 GO:0061196 biolink:BiologicalProcess fungiform papilla development The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue. go.json http://purl.obolibrary.org/obo/GO_0061196 GO:0061197 biolink:BiologicalProcess fungiform papilla morphogenesis The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue. go.json http://purl.obolibrary.org/obo/GO_0061197 GO:0061198 biolink:BiologicalProcess fungiform papilla formation The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue. go.json http://purl.obolibrary.org/obo/GO_0061198 GO:0061199 biolink:BiologicalProcess striated muscle contraction involved in embryonic body morphogenesis The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology. go.json http://purl.obolibrary.org/obo/GO_0061199 GO:0002838 biolink:BiologicalProcess negative regulation of immune response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell. go.json down regulation of immune response to tumor cell|down-regulation of immune response to tumor cell|downregulation of immune response to tumor cell|inhibition of immune response to tumor cell|negative regulation of immune response to tumour cell http://purl.obolibrary.org/obo/GO_0002838 GO:0002839 biolink:BiologicalProcess positive regulation of immune response to tumor cell Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. go.json activation of immune response to tumor cell|positive regulation of immune response to tumour cell|stimulation of immune response to tumor cell|up regulation of immune response to tumor cell|up-regulation of immune response to tumor cell|upregulation of immune response to tumor cell http://purl.obolibrary.org/obo/GO_0002839 GO:0002834 biolink:BiologicalProcess regulation of response to tumor cell Any process that modulates the frequency, rate, or extent of a response to tumor cell. go.json regulation of response to tumour cell http://purl.obolibrary.org/obo/GO_0002834 GO:0002835 biolink:BiologicalProcess negative regulation of response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell. go.json down regulation of response to tumor cell|down-regulation of response to tumor cell|downregulation of response to tumor cell|inhibition of response to tumor cell|negative regulation of response to tumour cell http://purl.obolibrary.org/obo/GO_0002835 GO:0002836 biolink:BiologicalProcess positive regulation of response to tumor cell Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. go.json activation of response to tumor cell|positive regulation of response to tumour cell|stimulation of response to tumor cell|up regulation of response to tumor cell|up-regulation of response to tumor cell|upregulation of response to tumor cell http://purl.obolibrary.org/obo/GO_0002836 GO:0002837 biolink:BiologicalProcess regulation of immune response to tumor cell Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. go.json regulation of immune response to tumour cell http://purl.obolibrary.org/obo/GO_0002837 GO:0002800 biolink:BiologicalProcess regulation of antifungal peptide secretion Any process that modulates the frequency, rate, or extent of antifungal peptide secretion. go.json http://purl.obolibrary.org/obo/GO_0002800 GO:0002809 biolink:BiologicalProcess negative regulation of antibacterial peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis. go.json down regulation of antibacterial peptide biosynthetic process|down-regulation of antibacterial peptide biosynthetic process|downregulation of antibacterial peptide biosynthetic process|inhibition of antibacterial peptide biosynthetic process http://purl.obolibrary.org/obo/GO_0002809 GO:0002805 biolink:BiologicalProcess regulation of antimicrobial peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0002805 GO:0002806 biolink:BiologicalProcess negative regulation of antimicrobial peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis. go.json down regulation of antimicrobial peptide biosynthetic process|down-regulation of antimicrobial peptide biosynthetic process|downregulation of antimicrobial peptide biosynthetic process|inhibition of antimicrobial peptide biosynthetic process http://purl.obolibrary.org/obo/GO_0002806 GO:0002807 biolink:BiologicalProcess positive regulation of antimicrobial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis. go.json activation of antimicrobial peptide biosynthetic process|stimulation of antimicrobial peptide biosynthetic process|up regulation of antimicrobial peptide biosynthetic process|up-regulation of antimicrobial peptide biosynthetic process|upregulation of antimicrobial peptide biosynthetic process http://purl.obolibrary.org/obo/GO_0002807 GO:0002808 biolink:BiologicalProcess regulation of antibacterial peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0002808 OBO:go#systematic_synonym biolink:OntologyClass Systematic synonym go.json http://purl.obolibrary.org/obo/go#systematic_synonym GO:0002801 biolink:BiologicalProcess negative regulation of antifungal peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion. go.json down regulation of antifungal peptide secretion|down-regulation of antifungal peptide secretion|downregulation of antifungal peptide secretion|inhibition of antifungal peptide secretion http://purl.obolibrary.org/obo/GO_0002801 GO:0002802 biolink:BiologicalProcess positive regulation of antifungal peptide secretion Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion. go.json activation of antifungal peptide secretion|stimulation of antifungal peptide secretion|up regulation of antifungal peptide secretion|up-regulation of antifungal peptide secretion|upregulation of antifungal peptide secretion http://purl.obolibrary.org/obo/GO_0002802 GO:0002803 biolink:BiologicalProcess positive regulation of antibacterial peptide production Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production. go.json activation of antibacterial peptide production|stimulation of antibacterial peptide production|up regulation of antibacterial peptide production|up-regulation of antibacterial peptide production|upregulation of antibacterial peptide production http://purl.obolibrary.org/obo/GO_0002803 GO:0002804 biolink:BiologicalProcess positive regulation of antifungal peptide production Any process that activates or increases the frequency, rate, or extent of antifungal peptide production. go.json activation of antifungal peptide production|stimulation of antifungal peptide production|up regulation of antifungal peptide production|up-regulation of antifungal peptide production|upregulation of antifungal peptide production http://purl.obolibrary.org/obo/GO_0002804 GO:0002810 biolink:BiologicalProcess regulation of antifungal peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0002810 GO:0002811 biolink:BiologicalProcess negative regulation of antifungal peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis. go.json down regulation of antifungal peptide biosynthetic process|down-regulation of antifungal peptide biosynthetic process|downregulation of antifungal peptide biosynthetic process|inhibition of antifungal peptide biosynthetic process http://purl.obolibrary.org/obo/GO_0002811 GO:0002816 biolink:BiologicalProcess regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria. go.json http://purl.obolibrary.org/obo/GO_0002816 GO:0002817 biolink:BiologicalProcess negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria. go.json down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria http://purl.obolibrary.org/obo/GO_0002817 GO:0002818 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002818 GO:0002819 biolink:BiologicalProcess regulation of adaptive immune response Any process that modulates the frequency, rate, or extent of an adaptive immune response. go.json http://purl.obolibrary.org/obo/GO_0002819 GO:0002812 biolink:BiologicalProcess biosynthetic process of antibacterial peptides active against Gram-negative bacteria The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria. go.json http://purl.obolibrary.org/obo/GO_0002812 GO:0002813 biolink:BiologicalProcess regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria. go.json http://purl.obolibrary.org/obo/GO_0002813 GO:0002814 biolink:BiologicalProcess negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria. go.json down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria http://purl.obolibrary.org/obo/GO_0002814 GO:0002815 biolink:BiologicalProcess biosynthetic process of antibacterial peptides active against Gram-positive bacteria The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria. go.json http://purl.obolibrary.org/obo/GO_0002815 GO:0075720 biolink:BiologicalProcess establishment of episomal latency A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity. go.json establishment as a plasmid prophage|establishment of plasmid latency http://purl.obolibrary.org/obo/GO_0075720 GO:0051753 biolink:MolecularActivity mannan synthase activity Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan. go.json galactomannan beta-1,4-mannosyltransferase activity|mannan beta-1,4-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0051753 GO:0051754 biolink:BiologicalProcess meiotic sister chromatid cohesion, centromeric The cell cycle process in which centromeres of sister chromatids are joined during meiosis. go.json centromeric meiotic sister chromatin cohesion|meiotic sister chromatid cohesion at centromere|sister chromatid cohesion at centromere at meiosis I http://purl.obolibrary.org/obo/GO_0051754 GO:0051751 biolink:MolecularActivity alpha-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage. go.json http://purl.obolibrary.org/obo/GO_0051751 GO:0051752 biolink:MolecularActivity phosphoglucan, water dikinase activity Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate. EC:2.7.9.5|MetaCyc:2.7.9.5-RXN go.json ATP:phospho-alpha-glucan, water phosphotransferase activity|OK1|PWD http://purl.obolibrary.org/obo/GO_0051752 GO:0051757 biolink:BiologicalProcess meiotic sister chromatid separation The process in which sister chromatids are physically detached from each other during meiosis. go.json meiotic sister chromatid resolution http://purl.obolibrary.org/obo/GO_0051757 GO:0051758 biolink:BiologicalProcess homologous chromosome movement towards spindle pole in meiosis I anaphase The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I anaphase. go.json homologous chromosome movement towards spindle pole during meiosis I|meiosis I, homologous chromosome movement towards spindle pole http://purl.obolibrary.org/obo/GO_0051758 GO:0051755 biolink:BiologicalProcess meiotic sister chromatid arm separation The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis. go.json http://purl.obolibrary.org/obo/GO_0051755 GO:0051756 biolink:BiologicalProcess meiotic sister chromatid centromere separation The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis. go.json http://purl.obolibrary.org/obo/GO_0051756 GO:0051759 biolink:BiologicalProcess sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II. go.json meiosis II, sister chromosome movement towards spindle pole|sister chromosome movement towards spindle pole during meiosis II http://purl.obolibrary.org/obo/GO_0051759 GO:0036112 biolink:BiologicalProcess medium-chain fatty-acyl-CoA metabolic process The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. go.json medium-chain fatty acyl CoA metabolic process|medium-chain fatty acyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0036112 GO:0036113 biolink:BiologicalProcess very long-chain fatty-acyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. go.json very long-chain fatty-acyl-CoA breakdown|very long-chain fatty-acyl-CoA catabolism|very long-chain fatty-acyl-CoA degradation http://purl.obolibrary.org/obo/GO_0036113 GO:0036114 biolink:BiologicalProcess medium-chain fatty-acyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. go.json medium-chain fatty-acyl-CoA breakdown|medium-chain fatty-acyl-CoA catabolism|medium-chain fatty-acyl-CoA degradation http://purl.obolibrary.org/obo/GO_0036114 GO:0036115 biolink:BiologicalProcess fatty-acyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. go.json fatty-acyl-CoA breakdown|fatty-acyl-CoA catabolism|fatty-acyl-CoA degradation http://purl.obolibrary.org/obo/GO_0036115 GO:0036116 biolink:BiologicalProcess long-chain fatty-acyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. go.json long-chain fatty-acyl-CoA breakdown|long-chain fatty-acyl-CoA catabolism|long-chain fatty-acyl-CoA degradation http://purl.obolibrary.org/obo/GO_0036116 GO:0036117 biolink:CellularComponent hyaluranon cable A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. go.json HA cable http://purl.obolibrary.org/obo/GO_0036117 GO:0036118 biolink:BiologicalProcess hyaluranon cable assembly A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. go.json HA cable assembly http://purl.obolibrary.org/obo/GO_0036118 GO:0036119 biolink:BiologicalProcess response to platelet-derived growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. go.json response to PDGF stimulus|response to platelet-derived growth factor stimulus http://purl.obolibrary.org/obo/GO_0036119 GO:0051750 biolink:MolecularActivity delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA. EC:5.3.3.21|RHEA:45240 go.json delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity|delta3,5-delta2,4-dienoyl-CoA isomerase activity|delta5-delta2,4-dienoyl-CoA isomerase activity http://purl.obolibrary.org/obo/GO_0051750 GO:0036110 biolink:BiologicalProcess cellular response to inositol starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol. go.json http://purl.obolibrary.org/obo/GO_0036110 GO:0036111 biolink:BiologicalProcess very long-chain fatty-acyl-CoA metabolic process The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. go.json very long-chain fatty acyl CoA metabolic process|very long-chain fatty acyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0036111 GO:0051764 biolink:BiologicalProcess actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. go.json actin bundling|actin crosslinking|bridging actin filaments|formation of actin crosslink http://purl.obolibrary.org/obo/GO_0051764 GO:0075710 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075710 GO:0051765 biolink:MolecularActivity inositol tetrakisphosphate kinase activity Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. go.json http://purl.obolibrary.org/obo/GO_0051765 GO:0051762 biolink:BiologicalProcess sesquiterpene biosynthetic process The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. go.json http://purl.obolibrary.org/obo/GO_0051762 GO:0051763 biolink:BiologicalProcess sesquiterpene catabolic process The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. go.json http://purl.obolibrary.org/obo/GO_0051763 GO:0075713 biolink:BiologicalProcess establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage. VZ:980 go.json prophage integration|provirus integration http://purl.obolibrary.org/obo/GO_0075713 GO:0051768 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051768 GO:0051769 biolink:BiologicalProcess regulation of nitric-oxide synthase biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. go.json regulation of NO synthase biosynthesis|regulation of NO synthase biosynthetic process|regulation of NOS biosynthesis|regulation of NOS biosynthetic process|regulation of NOS2 synthase biosynthesis|regulation of NOS2 synthase biosynthetic process|regulation of nitric-oxide synthase (type 2) biosynthesis|regulation of nitric-oxide synthase (type 2) biosynthetic process|regulation of nitric-oxide synthase (type II) biosynthesis|regulation of nitric-oxide synthase (type II) biosynthetic process|regulation of nitric-oxide synthase 2 biosynthetic process http://purl.obolibrary.org/obo/GO_0051769 GO:0051766 biolink:MolecularActivity inositol trisphosphate kinase activity Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. go.json IP3K http://purl.obolibrary.org/obo/GO_0051766 GO:0051767 biolink:BiologicalProcess nitric-oxide synthase biosynthetic process The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. go.json NO synthase biosynthesis|NO synthase biosynthetic process|NOS biosynthesis|NOS biosynthetic process|NOS1 biosynthesis|NOS2 biosynthesis|NOS2 synthase biosynthesis|NOS2 synthase biosynthetic process|NOS3 biosynthesis|brain nitric-oxide synthase biosynthetic process|endothelial nitric-oxide synthase biosynthetic process|inducible nitric-oxide synthase biosynthetic process|nitric-oxide synthase (type 2) biosynthesis|nitric-oxide synthase (type 2) biosynthetic process|nitric-oxide synthase (type II) biosynthesis|nitric-oxide synthase (type II) biosynthetic process|nitric-oxide synthase 2 biosynthetic process|nitric-oxide synthase-1 biosynthetic process|nitric-oxide synthase-2 biosynthetic process|nitric-oxide synthase-3 biosynthetic process http://purl.obolibrary.org/obo/GO_0051767 GO:0075716 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075716 GO:0036109 biolink:BiologicalProcess alpha-linolenic acid metabolic process The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. Wikipedia:Linoleic_acid go.json ALA metabolism|alpha-linolenic acid metabolism http://purl.obolibrary.org/obo/GO_0036109 GO:0075717 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075717 GO:0036101 biolink:BiologicalProcess leukotriene B4 catabolic process The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. go.json LTB4 catabolism|leukotriene B4 breakdown|leukotriene B4 catabolism|leukotriene B4 degradation http://purl.obolibrary.org/obo/GO_0036101 GO:0036102 biolink:BiologicalProcess leukotriene B4 metabolic process The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. go.json LTB4 metabolism http://purl.obolibrary.org/obo/GO_0036102 GO:0036103 biolink:BiologicalProcess Kdo2-lipid A metabolic process The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component. go.json Kdo2-lipid A metabolism http://purl.obolibrary.org/obo/GO_0036103 GO:0036104 biolink:BiologicalProcess Kdo2-lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component. go.json 3-deoxy-d-manno-octulosonic acid-lipid A biosynthesis|Kdo2-lipid A anabolism|Kdo2-lipid A biosynthesis|Kdo2-lipid A formation|Kdo2-lipid A synthesis http://purl.obolibrary.org/obo/GO_0036104 GO:0036105 biolink:MolecularActivity peroxisome membrane class-1 targeting sequence binding Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner. go.json PEX19-dependent mPTS binding|class 1 mPTS binding http://purl.obolibrary.org/obo/GO_0036105 GO:0036106 biolink:MolecularActivity peroxisome membrane class-2 targeting sequence binding Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner. go.json PEX19-independent mPTS binding|class 2 mPTS binding http://purl.obolibrary.org/obo/GO_0036106 GO:0036107 biolink:BiologicalProcess 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N). go.json 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate metabolic process|undecaprenyl phosphate alpha-L-Ara4N metabolism http://purl.obolibrary.org/obo/GO_0036107 GO:0036108 biolink:BiologicalProcess 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N). go.json 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism|4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis|4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation|4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis|undecaprenyl phosphate alpha-L-Ara4N biosynthesis http://purl.obolibrary.org/obo/GO_0036108 GO:0051760 biolink:BiologicalProcess obsolete meiotic sister chromatid cohesion, arms OBSOLETE. The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis. go.json meiotic sister chromatid cohesion along arms|sister chromatid cohesion along arms at meiosis I True http://purl.obolibrary.org/obo/GO_0051760 GO:0099703 biolink:BiologicalProcess induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0099703 goslim_synapse GO:0051761 biolink:BiologicalProcess sesquiterpene metabolic process The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. go.json sesquiterpene metabolism http://purl.obolibrary.org/obo/GO_0051761 GO:0036100 biolink:BiologicalProcess leukotriene catabolic process The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. go.json leukotriene breakdown|leukotriene catabolism|leukotriene degradation http://purl.obolibrary.org/obo/GO_0036100 GO:0051775 biolink:BiologicalProcess response to redox state Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. go.json redox signal response http://purl.obolibrary.org/obo/GO_0051775 GO:0051776 biolink:BiologicalProcess detection of redox state The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. go.json redox sensing http://purl.obolibrary.org/obo/GO_0051776 GO:0051773 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051773 GO:0051774 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051774 GO:0051779 biolink:MolecularActivity gibberellin 12-aldehyde oxidase activity Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). MetaCyc:RXN1F-161|RHEA:22700 go.json GA12-aldehyde oxidase activity http://purl.obolibrary.org/obo/GO_0051779 GO:0051777 biolink:MolecularActivity ent-kaurenoate oxidase activity Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). MetaCyc:1.14.13.79-RXN|RHEA:19241 go.json ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity|ent-kaurenoic acid oxidase activity http://purl.obolibrary.org/obo/GO_0051777 GO:0051778 biolink:MolecularActivity ent-7-alpha-hydroxykaurenoate oxidase activity Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). MetaCyc:RXN1F-160|RHEA:22904 go.json http://purl.obolibrary.org/obo/GO_0051778 GO:0061100 biolink:BiologicalProcess lung neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. go.json http://purl.obolibrary.org/obo/GO_0061100 GO:0061101 biolink:BiologicalProcess neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. go.json http://purl.obolibrary.org/obo/GO_0061101 GO:0061102 biolink:BiologicalProcess stomach neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. go.json gastric neuroendocrine cell differentiation http://purl.obolibrary.org/obo/GO_0061102 GO:0061103 biolink:BiologicalProcess carotid body glomus cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia. go.json http://purl.obolibrary.org/obo/GO_0061103 GO:0061104 biolink:BiologicalProcess adrenal chromaffin cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles. go.json http://purl.obolibrary.org/obo/GO_0061104 GO:0061105 biolink:BiologicalProcess regulation of stomach neuroendocrine cell differentiation Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. go.json http://purl.obolibrary.org/obo/GO_0061105 GO:0061106 biolink:BiologicalProcess negative regulation of stomach neuroendocrine cell differentiation Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. go.json http://purl.obolibrary.org/obo/GO_0061106 GO:0061107 biolink:BiologicalProcess seminal vesicle development The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen. go.json http://purl.obolibrary.org/obo/GO_0061107 GO:0061108 biolink:BiologicalProcess seminal vesicle epithelium development The progression of the seminal vesicle epithelium over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061108 GO:0061109 biolink:BiologicalProcess dense core granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. go.json dense core granule organisation http://purl.obolibrary.org/obo/GO_0061109 GO:0051771 biolink:BiologicalProcess negative regulation of nitric-oxide synthase biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. go.json down regulation of nitric-oxide synthase 2 biosynthetic process|down regulation of nitric-oxide synthase biosynthetic process|down-regulation of nitric-oxide synthase 2 biosynthetic process|down-regulation of nitric-oxide synthase biosynthetic process|downregulation of nitric-oxide synthase 2 biosynthetic process|downregulation of nitric-oxide synthase biosynthetic process|inhibition of nitric-oxide synthase 2 biosynthetic process|inhibition of nitric-oxide synthase biosynthetic process|negative regulation of NO synthase biosynthesis|negative regulation of NO synthase biosynthetic process|negative regulation of NOS biosynthesis|negative regulation of NOS biosynthetic process|negative regulation of NOS2 synthase biosynthesis|negative regulation of NOS2 synthase biosynthetic process|negative regulation of nitric-oxide synthase (type 2) biosynthesis|negative regulation of nitric-oxide synthase (type 2) biosynthetic process|negative regulation of nitric-oxide synthase (type II) biosynthesis|negative regulation of nitric-oxide synthase (type II) biosynthetic process|negative regulation of nitric-oxide synthase 2 biosynthetic process http://purl.obolibrary.org/obo/GO_0051771 GO:0051772 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051772 GO:0051770 biolink:BiologicalProcess positive regulation of nitric-oxide synthase biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. go.json activation of nitric-oxide synthase 2 biosynthetic process|activation of nitric-oxide synthase biosynthetic process|positive regulation of NO synthase biosynthesis|positive regulation of NO synthase biosynthetic process|positive regulation of NOS biosynthesis|positive regulation of NOS biosynthetic process|positive regulation of NOS2 synthase biosynthesis|positive regulation of NOS2 synthase biosynthetic process|positive regulation of nitric-oxide synthase (type 2) biosynthesis|positive regulation of nitric-oxide synthase (type 2) biosynthetic process|positive regulation of nitric-oxide synthase (type II) biosynthesis|positive regulation of nitric-oxide synthase (type II) biosynthetic process|positive regulation of nitric-oxide synthase 2 biosynthetic process|stimulation of nitric-oxide synthase 2 biosynthetic process|stimulation of nitric-oxide synthase biosynthetic process|up regulation of nitric-oxide synthase 2 biosynthetic process|up regulation of nitric-oxide synthase biosynthetic process|up-regulation of nitric-oxide synthase 2 biosynthetic process|up-regulation of nitric-oxide synthase biosynthetic process|upregulation of nitric-oxide synthase 2 biosynthetic process|upregulation of nitric-oxide synthase biosynthetic process http://purl.obolibrary.org/obo/GO_0051770 GO:0051786 biolink:MolecularActivity all-trans-retinol 13,14-reductase activity Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction. EC:1.3.99.23|KEGG_REACTION:R07163|MetaCyc:1.3.99.23-RXN|RHEA:19193|Reactome:R-HSA-8956427 go.json (13,14)-all-trans-retinol saturase activity|RetSat activity|all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity|all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity|retinol saturase activity http://purl.obolibrary.org/obo/GO_0051786 GO:0051787 biolink:MolecularActivity misfolded protein binding Binding to a misfolded protein. Reactome:R-HSA-5324632 go.json http://purl.obolibrary.org/obo/GO_0051787 GO:0075732 biolink:BiologicalProcess viral penetration into host nucleus The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid. VZ:989 go.json viral entry into host nucleus|viral import into host nucleus http://purl.obolibrary.org/obo/GO_0075732 GO:0051784 biolink:BiologicalProcess negative regulation of nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. go.json down regulation of nuclear division|down-regulation of nuclear division|downregulation of nuclear division|inhibition of nuclear division http://purl.obolibrary.org/obo/GO_0051784 GO:0075733 biolink:BiologicalProcess intracellular transport of virus The directed movement of a virus, or part of a virus, within the host cell. go.json egress of virus within host cell|intracellular transport of viral material|intracellular virion transport|movement of virus within host cell|viral egress|viral genome transport in host cell http://purl.obolibrary.org/obo/GO_0075733 GO:0051785 biolink:BiologicalProcess positive regulation of nuclear division Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. go.json activation of nuclear division|stimulation of nuclear division|up regulation of nuclear division|up-regulation of nuclear division|upregulation of nuclear division http://purl.obolibrary.org/obo/GO_0051785 GO:0051788 biolink:BiologicalProcess response to misfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. go.json http://purl.obolibrary.org/obo/GO_0051788 GO:0051789 biolink:BiologicalProcess obsolete response to protein OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus. go.json response to protein|response to protein stimulus True http://purl.obolibrary.org/obo/GO_0051789 GO:0051782 biolink:BiologicalProcess negative regulation of cell division Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. go.json down regulation of cell division|down-regulation of cell division|downregulation of cell division|inhibition of cell division http://purl.obolibrary.org/obo/GO_0051782 GO:0051783 biolink:BiologicalProcess regulation of nuclear division Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. go.json http://purl.obolibrary.org/obo/GO_0051783 GO:0051780 biolink:BiologicalProcess behavioral response to nutrient Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus. go.json behavioural response to nutrient http://purl.obolibrary.org/obo/GO_0051780 GO:0051781 biolink:BiologicalProcess positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division. go.json activation of cell division|stimulation of cell division|up regulation of cell division|up-regulation of cell division|upregulation of cell division http://purl.obolibrary.org/obo/GO_0051781 GO:0051797 biolink:BiologicalProcess regulation of hair follicle development Any process that modulates the frequency, rate or extent of hair follicle development. go.json http://purl.obolibrary.org/obo/GO_0051797 GO:0002786 biolink:BiologicalProcess regulation of antibacterial peptide production Any process that modulates the frequency, rate, or extent of antibacterial peptide production. go.json http://purl.obolibrary.org/obo/GO_0002786 GO:0002787 biolink:BiologicalProcess negative regulation of antibacterial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production. go.json down regulation of antibacterial peptide production|down-regulation of antibacterial peptide production|downregulation of antibacterial peptide production|inhibition of antibacterial peptide production http://purl.obolibrary.org/obo/GO_0002787 GO:0051798 biolink:BiologicalProcess positive regulation of hair follicle development Any process that activates or increases the frequency, rate or extent of hair follicle development. go.json activation of hair follicle development|stimulation of hair follicle development|up regulation of hair follicle development|up-regulation of hair follicle development|upregulation of hair follicle development http://purl.obolibrary.org/obo/GO_0051798 GO:0002788 biolink:BiologicalProcess regulation of antifungal peptide production Any process that modulates the frequency, rate, or extent of antifungal peptide production. go.json http://purl.obolibrary.org/obo/GO_0002788 GO:0051795 biolink:BiologicalProcess positive regulation of timing of catagen Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. go.json activation of catagen|positive regulation of catagen|stimulation of catagen|up regulation of catagen|up-regulation of catagen|upregulation of catagen http://purl.obolibrary.org/obo/GO_0051795 GO:0051796 biolink:BiologicalProcess negative regulation of timing of catagen Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. go.json down regulation of catagen|down-regulation of catagen|downregulation of catagen|inhibition of catagen|negative regulation of catagen http://purl.obolibrary.org/obo/GO_0051796 GO:0002789 biolink:BiologicalProcess negative regulation of antifungal peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production. go.json down regulation of antifungal peptide production|down-regulation of antifungal peptide production|downregulation of antifungal peptide production|inhibition of antifungal peptide production http://purl.obolibrary.org/obo/GO_0002789 GO:0002782 biolink:BiologicalProcess antifungal peptide secretion The regulated release of an antifungal peptide from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0002782 GO:0002783 biolink:BiologicalProcess antifungal peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antifungal peptide. go.json http://purl.obolibrary.org/obo/GO_0002783 GO:0051799 biolink:BiologicalProcess negative regulation of hair follicle development Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development. go.json down regulation of hair follicle development|down-regulation of hair follicle development|downregulation of hair follicle development|inhibition of hair follicle development http://purl.obolibrary.org/obo/GO_0051799 GO:0002784 biolink:BiologicalProcess regulation of antimicrobial peptide production Any process that modulates the frequency, rate, or extent of antimicrobial peptide production. go.json http://purl.obolibrary.org/obo/GO_0002784 GO:0002785 biolink:BiologicalProcess negative regulation of antimicrobial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production. go.json down regulation of antimicrobial peptide production|down-regulation of antimicrobial peptide production|downregulation of antimicrobial peptide production|inhibition of antimicrobial peptide production http://purl.obolibrary.org/obo/GO_0002785 GO:0002780 biolink:BiologicalProcess antibacterial peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antibacterial peptide. go.json http://purl.obolibrary.org/obo/GO_0002780 GO:0002781 biolink:BiologicalProcess antifungal peptide production The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0002781 gocheck_do_not_annotate GO:0061120 biolink:BiologicalProcess regulation of positive chemotaxis to cAMP by DIF-1 Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. go.json http://purl.obolibrary.org/obo/GO_0061120 GO:0061121 biolink:BiologicalProcess regulation of positive chemotaxis to cAMP by DIF-2 Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. go.json http://purl.obolibrary.org/obo/GO_0061121 GO:0061122 biolink:BiologicalProcess positive regulation of positive chemotaxis to cAMP Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. go.json http://purl.obolibrary.org/obo/GO_0061122 GO:0061123 biolink:BiologicalProcess negative regulation of positive chemotaxis to cAMP Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. go.json http://purl.obolibrary.org/obo/GO_0061123 GO:0061124 biolink:BiologicalProcess positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. go.json http://purl.obolibrary.org/obo/GO_0061124 GO:0061125 biolink:BiologicalProcess negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. go.json http://purl.obolibrary.org/obo/GO_0061125 GO:0061126 biolink:BiologicalProcess positive regulation of positive chemotaxis to cAMP by DIF-1 Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. go.json http://purl.obolibrary.org/obo/GO_0061126 GO:0061127 biolink:BiologicalProcess negative regulation of positive chemotaxis to cAMP by DIF-1 Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. go.json http://purl.obolibrary.org/obo/GO_0061127 GO:0061128 biolink:BiologicalProcess positive regulation of chemotaxis to cAMP by DIF-2 Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. go.json http://purl.obolibrary.org/obo/GO_0061128 GO:0061129 biolink:BiologicalProcess negative regulation of positive chemotaxis to cAMP by DIF-2 Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. go.json http://purl.obolibrary.org/obo/GO_0061129 GO:0051790 biolink:BiologicalProcess short-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of less than 6 carbons. go.json short chain fatty acid biosynthesis|short chain fatty acid biosynthetic process|short-chain fatty acid anabolism|short-chain fatty acid biosynthesis|short-chain fatty acid formation|short-chain fatty acid synthesis http://purl.obolibrary.org/obo/GO_0051790 GO:0099738 biolink:CellularComponent cell cortex region The complete extent of cell cortex that underlies some some region of the plasma membrane. go.json perimembrane region http://purl.obolibrary.org/obo/GO_0099738 gocheck_do_not_annotate GO:0051793 biolink:BiologicalProcess medium-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of 6 to 12 carbons. go.json medium chain fatty acid catabolic process|medium chain fatty acid catabolism|medium-chain fatty acid breakdown|medium-chain fatty acid catabolism|medium-chain fatty acid degradation http://purl.obolibrary.org/obo/GO_0051793 GO:0051794 biolink:BiologicalProcess regulation of timing of catagen Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. go.json regulation of catagen http://purl.obolibrary.org/obo/GO_0051794 GO:0051791 biolink:BiologicalProcess medium-chain fatty acid metabolic process The chemical reactions and pathways involving a medium-chain fatty acid, a fatty acid with an aliphatic tail of 6 to 12 carbons. go.json medium chain fatty acid metabolic process|medium chain fatty acid metabolism|medium-chain fatty acid metabolism http://purl.obolibrary.org/obo/GO_0051791 GO:0051792 biolink:BiologicalProcess medium-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of 6 to 12 carbons. go.json medium chain fatty acid biosynthesis|medium chain fatty acid biosynthetic process|medium-chain fatty acid anabolism|medium-chain fatty acid biosynthesis|medium-chain fatty acid formation|medium-chain fatty acid synthesis http://purl.obolibrary.org/obo/GO_0051792 GO:0002797 biolink:BiologicalProcess regulation of antibacterial peptide secretion Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion. go.json http://purl.obolibrary.org/obo/GO_0002797 GO:0002798 biolink:BiologicalProcess negative regulation of antibacterial peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion. go.json down regulation of antibacterial peptide secretion|down-regulation of antibacterial peptide secretion|downregulation of antibacterial peptide secretion|inhibition of antibacterial peptide secretion http://purl.obolibrary.org/obo/GO_0002798 GO:0002799 biolink:BiologicalProcess positive regulation of antibacterial peptide secretion Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion. go.json activation of antibacterial peptide secretion|stimulation of antibacterial peptide secretion|up regulation of antibacterial peptide secretion|up-regulation of antibacterial peptide secretion|upregulation of antibacterial peptide secretion http://purl.obolibrary.org/obo/GO_0002799 GO:0002793 biolink:BiologicalProcess positive regulation of peptide secretion Any process that activates or increases the frequency, rate, or extent of peptide secretion. go.json activation of peptide secretion|stimulation of peptide secretion|up regulation of peptide secretion|up-regulation of peptide secretion|upregulation of peptide secretion http://purl.obolibrary.org/obo/GO_0002793 GO:0002794 biolink:BiologicalProcess regulation of antimicrobial peptide secretion Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion. go.json http://purl.obolibrary.org/obo/GO_0002794 GO:0002795 biolink:BiologicalProcess negative regulation of antimicrobial peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion. go.json down regulation of antimicrobial peptide secretion|down-regulation of antimicrobial peptide secretion|downregulation of antimicrobial peptide secretion|inhibition of antimicrobial peptide secretion http://purl.obolibrary.org/obo/GO_0002795 GO:0002796 biolink:BiologicalProcess positive regulation of antimicrobial peptide secretion Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion. go.json activation of antimicrobial peptide secretion|stimulation of antimicrobial peptide secretion|up regulation of antimicrobial peptide secretion|up-regulation of antimicrobial peptide secretion|upregulation of antimicrobial peptide secretion http://purl.obolibrary.org/obo/GO_0002796 GO:0002790 biolink:BiologicalProcess peptide secretion The controlled release of a peptide from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0002790 GO:0002791 biolink:BiologicalProcess regulation of peptide secretion Any process that modulates the frequency, rate, or extent of peptide secretion. go.json http://purl.obolibrary.org/obo/GO_0002791 GO:0002792 biolink:BiologicalProcess negative regulation of peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. go.json down regulation of peptide secretion|down-regulation of peptide secretion|downregulation of peptide secretion|inhibition of peptide secretion http://purl.obolibrary.org/obo/GO_0002792 GO:0061110 biolink:BiologicalProcess dense core granule biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule. go.json http://purl.obolibrary.org/obo/GO_0061110 GO:0061111 biolink:BiologicalProcess epithelial-mesenchymal cell signaling involved in lung development Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. go.json epithelial-mesenchymal cell signalling involved in lung development http://purl.obolibrary.org/obo/GO_0061111 GO:0061112 biolink:BiologicalProcess negative regulation of bud outgrowth involved in lung branching Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching. go.json http://purl.obolibrary.org/obo/GO_0061112 GO:0061113 biolink:BiologicalProcess pancreas morphogenesis Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061113 GO:0061114 biolink:BiologicalProcess branching involved in pancreas morphogenesis The process in which the branches of the pancreas are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061114 GO:0061115 biolink:BiologicalProcess lung proximal/distal axis specification The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli. go.json http://purl.obolibrary.org/obo/GO_0061115 GO:0061116 biolink:BiologicalProcess ductus venosus closure The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth. go.json http://purl.obolibrary.org/obo/GO_0061116 GO:0061117 biolink:BiologicalProcess negative regulation of heart growth Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. go.json http://purl.obolibrary.org/obo/GO_0061117 GO:0061118 biolink:BiologicalProcess regulation of positive chemotaxis to cAMP Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. go.json http://purl.obolibrary.org/obo/GO_0061118 GO:0061119 biolink:BiologicalProcess regulation of positive chemotaxis to cAMP by chlorinated alkylphenone Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. go.json http://purl.obolibrary.org/obo/GO_0061119 GO:0002764 biolink:BiologicalProcess immune response-regulating signaling pathway The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response. go.json immune response-regulating signalling pathway http://purl.obolibrary.org/obo/GO_0002764 GO:0002765 biolink:BiologicalProcess immune response-inhibiting signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response. go.json http://purl.obolibrary.org/obo/GO_0002765 GO:0002766 biolink:BiologicalProcess innate immune response-inhibiting signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response. go.json http://purl.obolibrary.org/obo/GO_0002766 GO:0002767 biolink:BiologicalProcess immune response-inhibiting cell surface receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response. go.json immune response-inhibiting cell surface receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002767 GO:0002760 biolink:BiologicalProcess positive regulation of antimicrobial humoral response Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response. go.json activation of antimicrobial humoral response|stimulation of antimicrobial humoral response|up regulation of antimicrobial humoral response|up-regulation of antimicrobial humoral response|upregulation of antimicrobial humoral response http://purl.obolibrary.org/obo/GO_0002760 GO:0002761 biolink:BiologicalProcess regulation of myeloid leukocyte differentiation Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0002761 GO:0002762 biolink:BiologicalProcess negative regulation of myeloid leukocyte differentiation Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. go.json down regulation of myeloid leukocyte differentiation|down-regulation of myeloid leukocyte differentiation|downregulation of myeloid leukocyte differentiation|inhibition of myeloid leukocyte differentiation http://purl.obolibrary.org/obo/GO_0002762 GO:0002763 biolink:BiologicalProcess positive regulation of myeloid leukocyte differentiation Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. go.json activation of myeloid leukocyte differentiation|stimulation of myeloid leukocyte differentiation|up regulation of myeloid leukocyte differentiation|up-regulation of myeloid leukocyte differentiation|upregulation of myeloid leukocyte differentiation http://purl.obolibrary.org/obo/GO_0002763 GO:0061140 biolink:BiologicalProcess lung secretory cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. go.json http://purl.obolibrary.org/obo/GO_0061140 GO:0061141 biolink:BiologicalProcess lung ciliated cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. go.json http://purl.obolibrary.org/obo/GO_0061141 GO:0061142 biolink:BiologicalProcess mesothelial-mesenchymal cell signaling involved in early lung development Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung. go.json mesothelial-mesenchymal cell signalling involved in early lung development http://purl.obolibrary.org/obo/GO_0061142 GO:0061143 biolink:BiologicalProcess alveolar primary septum development The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms. go.json http://purl.obolibrary.org/obo/GO_0061143 GO:0061144 biolink:BiologicalProcess alveolar secondary septum development The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule. go.json http://purl.obolibrary.org/obo/GO_0061144 GO:0061145 biolink:BiologicalProcess lung smooth muscle development The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061145 GO:0061146 biolink:BiologicalProcess Peyer's patch morphogenesis The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. go.json http://purl.obolibrary.org/obo/GO_0061146 GO:0061147 biolink:BiologicalProcess endocardial endothelium development The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. go.json http://purl.obolibrary.org/obo/GO_0061147 GO:0061148 biolink:BiologicalProcess extracellular matrix organization involved in endocardium development A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. go.json extracellular matrix organisation involved in endocardium development http://purl.obolibrary.org/obo/GO_0061148 GO:0061149 biolink:BiologicalProcess obsolete BMP signaling pathway involved in ureter morphogenesis OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder. go.json BMP signalling pathway involved in ureter morphogenesis True http://purl.obolibrary.org/obo/GO_0061149 GO:0002768 biolink:BiologicalProcess immune response-regulating cell surface receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. go.json immune response-regulating cell surface receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002768 GO:0002769 biolink:BiologicalProcess natural killer cell inhibitory signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response. go.json Ly49 inhibitory receptor signaling pathway|NK cell inhibitory signaling pathway|inhibitory KIR signaling pathway|killer cell inhibitory receptor signaling pathway|natural killer cell inhibitory signalling pathway http://purl.obolibrary.org/obo/GO_0002769 GO:0002775 biolink:BiologicalProcess antimicrobial peptide production The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. go.json http://purl.obolibrary.org/obo/GO_0002775 gocheck_do_not_annotate GO:0002776 biolink:BiologicalProcess antimicrobial peptide secretion The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. go.json http://purl.obolibrary.org/obo/GO_0002776 GO:0002777 biolink:BiologicalProcess antimicrobial peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. go.json http://purl.obolibrary.org/obo/GO_0002777 GO:0002778 biolink:BiologicalProcess antibacterial peptide production The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0002778 gocheck_do_not_annotate GO:0002771 biolink:BiologicalProcess inhibitory killer cell immunoglobulin-like receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response. go.json KIR signaling pathway|inhibitory killer cell immunoglobulin-like receptor signalling pathway|killer cell inhibitory receptor signaling pathway http://purl.obolibrary.org/obo/GO_0002771 GO:0002772 biolink:BiologicalProcess inhibitory C-type lectin receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response. go.json Ly49 inhibitory receptor signaling pathway|inhibitory C-type lectin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002772 GO:0002773 biolink:BiologicalProcess B cell inhibitory signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response. go.json B cell inhibitory signalling pathway|B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway|B-cell inhibitory signaling pathway http://purl.obolibrary.org/obo/GO_0002773 GO:0002774 biolink:BiologicalProcess Fc receptor mediated inhibitory signaling pathway The series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. go.json Fc receptor mediated inhibitory signalling pathway|Fc-receptor mediated inhibitory signaling pathway http://purl.obolibrary.org/obo/GO_0002774 GO:0002770 biolink:BiologicalProcess T cell inhibitory signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response. go.json T cell inhibitory signalling pathway|T lymphocyte inhibitory signaling pathway|T-cell inhibitory signaling pathway|T-lymphocyte inhibitory signaling pathway http://purl.obolibrary.org/obo/GO_0002770 GO:0061130 biolink:BiologicalProcess pancreatic bud formation The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. go.json http://purl.obolibrary.org/obo/GO_0061130 GO:0061131 biolink:BiologicalProcess pancreas field specification The process in which a specific region of the gut is delineated into the area in which the pancreas will develop. go.json http://purl.obolibrary.org/obo/GO_0061131 GO:0061132 biolink:BiologicalProcess pancreas induction The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas. go.json http://purl.obolibrary.org/obo/GO_0061132 GO:0061133 biolink:MolecularActivity endopeptidase activator activity Binds to and increases the activity of an endopeptidase. go.json http://purl.obolibrary.org/obo/GO_0061133 GO:0061134 biolink:MolecularActivity peptidase regulator activity Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. go.json http://purl.obolibrary.org/obo/GO_0061134 GO:0061135 biolink:MolecularActivity endopeptidase regulator activity Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. go.json http://purl.obolibrary.org/obo/GO_0061135 GO:0061136 biolink:BiologicalProcess regulation of proteasomal protein catabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. go.json http://purl.obolibrary.org/obo/GO_0061136 GO:0061137 biolink:BiologicalProcess bud dilation The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch. go.json http://purl.obolibrary.org/obo/GO_0061137 GO:0061138 biolink:BiologicalProcess morphogenesis of a branching epithelium The process in which the anatomical structures of a branched epithelium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061138 GO:0061139 biolink:BiologicalProcess bud field specification The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0061139 GO:0002779 biolink:BiologicalProcess antibacterial peptide secretion The regulated release of an antibacterial peptide from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0002779 GO:0036192 biolink:MolecularActivity 3-hydroxyindolin-2-one monooxygenase activity Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O. EC:1.14.14.109|KEGG_REACTION:R07422|RHEA:31927 go.json 3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming) http://purl.obolibrary.org/obo/GO_0036192 GO:0036193 biolink:MolecularActivity 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O. EC:1.14.14.110|KEGG_REACTION:R07423|RHEA:31939 go.json http://purl.obolibrary.org/obo/GO_0036193 GO:0036194 biolink:CellularComponent muscle cell projection A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. go.json muscle arm|myocyte projection|myopodia http://purl.obolibrary.org/obo/GO_0036194 GO:0036195 biolink:CellularComponent muscle cell projection membrane The portion of the plasma membrane surrounding a muscle cell projection. go.json http://purl.obolibrary.org/obo/GO_0036195 GO:0036196 biolink:BiologicalProcess zymosterol metabolic process The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol). go.json http://purl.obolibrary.org/obo/GO_0036196 GO:0036197 biolink:BiologicalProcess zymosterol biosynthetic process The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol). MetaCyc:PWY-6074 go.json zymosterol anabolism|zymosterol biosynthesis|zymosterol formation|zymosterol synthesis http://purl.obolibrary.org/obo/GO_0036197 GO:0036198 biolink:BiologicalProcess dTMP salvage Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis. go.json dTMP biosynthesis via salvage pathway|deoxythymidine monophosphate biosynthesis via salvage pathway http://purl.obolibrary.org/obo/GO_0036198 GO:0036199 biolink:MolecularActivity cholest-4-en-3-one 26-monooxygenase activity Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate. EC:1.14.15.29|KEGG_REACTION:R09859|RHEA:51564 go.json http://purl.obolibrary.org/obo/GO_0036199 GO:0036190 biolink:MolecularActivity indole-2-monooxygenase activity Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O. EC:1.14.14.153|KEGG_REACTION:R07403|RHEA:31899 go.json http://purl.obolibrary.org/obo/GO_0036190 GO:0036191 biolink:MolecularActivity indolin-2-one monooxygenase activity Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O. EC:1.14.14.157|KEGG_REACTION:R07421|RHEA:31919 go.json indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating) http://purl.obolibrary.org/obo/GO_0036191 GO:0120109 biolink:BiologicalProcess mitotic telomere clustering and tethering at nuclear periphery The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0120109 GO:0120105 biolink:CellularComponent mitotic actomyosin contractile ring, intermediate layer The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer. go.json actomyosin contractile ring, intermediate layer http://purl.obolibrary.org/obo/GO_0120105 GO:0120106 biolink:CellularComponent mitotic actomyosin contractile ring, distal actin filament layer The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to. go.json actomyosin contractile ring, distal actin filament layer http://purl.obolibrary.org/obo/GO_0120106 GO:0120107 biolink:CellularComponent bacterial-type flagellum rotor complex The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation. go.json http://purl.obolibrary.org/obo/GO_0120107 GO:0120108 biolink:MolecularActivity DNA-3'-diphospho-5'-guanosine diphosphatase Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP. EC:3.6.1.72|RHEA:52140 go.json DNA-3'pp5'G guanylate hydrolase http://purl.obolibrary.org/obo/GO_0120108 GO:0036189 biolink:MolecularActivity abieta-7,13-diene hydroxylase activity Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O. EC:1.14.14.144|KEGG_REACTION:R06351|MetaCyc:RXN-8507|RHEA:26217 go.json abietadiene hydroxylase http://purl.obolibrary.org/obo/GO_0036189 GO:0120101 biolink:CellularComponent bacterial-type flagellum stator complex A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. go.json bacterial-type flagellum motor force generator complex|bacterial-type flagellum torque generator complex http://purl.obolibrary.org/obo/GO_0120101 GO:0120102 biolink:CellularComponent bacterial-type flagellum secretion apparatus A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament. go.json bacterial-type flagellum export apparatus http://purl.obolibrary.org/obo/GO_0120102 GO:0120103 biolink:CellularComponent centriolar subdistal appendage A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68. go.json subdistal appendage of basal body|subdistal appendage of centriole|subdistal appendage of mother centriole http://purl.obolibrary.org/obo/GO_0120103 GO:0120104 biolink:CellularComponent mitotic actomyosin contractile ring, proximal layer The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located. go.json actomyosin contractile ring, proximal layer http://purl.obolibrary.org/obo/GO_0120104 GO:0120100 biolink:CellularComponent bacterial-type flagellum motor A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation. go.json http://purl.obolibrary.org/obo/GO_0120100 GO:0036181 biolink:BiologicalProcess protein localization to linear element A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. go.json protein localisation to linear element http://purl.obolibrary.org/obo/GO_0036181 GO:0036182 biolink:BiologicalProcess asperthecin metabolic process The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. go.json asperthecin metabolism http://purl.obolibrary.org/obo/GO_0036182 GO:0036183 biolink:BiologicalProcess asperthecin catabolic process The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. go.json asperthecin breakdown|asperthecin catabolism|asperthecin degradation http://purl.obolibrary.org/obo/GO_0036183 GO:0036184 biolink:BiologicalProcess asperthecin biosynthetic process The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. go.json asperthecin biosynthesis|asperthecin formation|asperthecin synthesis http://purl.obolibrary.org/obo/GO_0036184 GO:0036185 biolink:MolecularActivity 13-lipoxin reductase activity Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+. Reactome:R-HSA-2161844 go.json http://purl.obolibrary.org/obo/GO_0036185 GO:0036186 biolink:CellularComponent early phagosome membrane The lipid bilayer surrounding an early phagosome. go.json early phagocytic vesicle membrane http://purl.obolibrary.org/obo/GO_0036186 GO:0036187 biolink:BiologicalProcess cell growth mode switching, budding to filamentous The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans. go.json yeast to hyphal transition http://purl.obolibrary.org/obo/GO_0036187 GO:0036188 biolink:MolecularActivity abieta-7,13-dien-18-al dehydrogenase activity Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+. EC:1.2.1.74|KEGG_REACTION:R06357|MetaCyc:RXN-10624|RHEA:26225 go.json abietadienal dehydrogenase http://purl.obolibrary.org/obo/GO_0036188 GO:0036180 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms in response to biotic stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus. go.json http://purl.obolibrary.org/obo/GO_0036180 GO:0120116 biolink:BiologicalProcess glucagon processing The formation of mature glucagon by proteolysis of the precursor proglucagon. go.json http://purl.obolibrary.org/obo/GO_0120116 GO:0120117 biolink:BiologicalProcess T cell meandering migration The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs). go.json T cell meandering search|lymph node surveillance http://purl.obolibrary.org/obo/GO_0120117 GO:0120118 biolink:CellularComponent flagella connector A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum. go.json http://purl.obolibrary.org/obo/GO_0120118 GO:0120119 biolink:CellularComponent flagellum attachment zone A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species. go.json FAZ http://purl.obolibrary.org/obo/GO_0120119 GO:0120112 biolink:BiologicalProcess UDP-glucose transmembrane transport into endoplasmic reticulum The directed movement of UDP-glucose from cytosol to endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0120112 GO:0036178 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms in response to neutral pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus. go.json http://purl.obolibrary.org/obo/GO_0036178 GO:0120113 biolink:BiologicalProcess cytoplasm to vacuole transport by the NVT pathway A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe. go.json cytoplasm to vacuole targeting|cytoplasm-to-vacuole targeting|protein localization by the NVT pathway|protein localization by the Nbr1-mediated vacuolar targeting pathway http://purl.obolibrary.org/obo/GO_0120113 GO:0036179 biolink:BiologicalProcess osteoclast maturation A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. go.json chondroclast maturation http://purl.obolibrary.org/obo/GO_0036179 GO:0120114 biolink:CellularComponent Sm-like protein family complex A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles. go.json http://purl.obolibrary.org/obo/GO_0120114 GO:0120115 biolink:CellularComponent Lsm2-8 complex A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus. go.json http://purl.obolibrary.org/obo/GO_0120115 GO:0120110 biolink:BiologicalProcess interphase mitotic telomere clustering The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope. go.json mitotic telomere clustering during interphase http://purl.obolibrary.org/obo/GO_0120110 GO:0120111 biolink:CellularComponent neuron projection cytoplasm All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. go.json http://purl.obolibrary.org/obo/GO_0120111 GO:0036170 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms in response to starvation The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment. go.json http://purl.obolibrary.org/obo/GO_0036170 GO:0036171 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms in response to chemical stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus. go.json http://purl.obolibrary.org/obo/GO_0036171 GO:0036172 biolink:BiologicalProcess thiamine salvage A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis. MetaCyc:PWY-6896|MetaCyc:PWY-6897|MetaCyc:PWY-6898 go.json http://purl.obolibrary.org/obo/GO_0036172 GO:0036173 biolink:MolecularActivity thiosulfate binding Binding to a thiosulfate, a sulfur oxide that has formula O3S2. go.json http://purl.obolibrary.org/obo/GO_0036173 GO:0036174 biolink:MolecularActivity butane monooxygenase activity Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O. go.json sBMO|soluble butane monooxygenase http://purl.obolibrary.org/obo/GO_0036174 GO:0036175 biolink:MolecularActivity ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin. Reactome:R-HSA-111742|Reactome:R-HSA-8866405 go.json http://purl.obolibrary.org/obo/GO_0036175 GO:0036176 biolink:BiologicalProcess response to neutral pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. go.json http://purl.obolibrary.org/obo/GO_0036176 GO:0036177 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms in response to pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. go.json http://purl.obolibrary.org/obo/GO_0036177 GO:0051702 biolink:BiologicalProcess biological process involved in interaction with symbiont An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. go.json interaction with symbiont http://purl.obolibrary.org/obo/GO_0051702 GO:0051703 biolink:BiologicalProcess biological process involved in intraspecies interaction between organisms Any process in which an organism has an effect on an organism of the same species. go.json intraspecies interaction between organisms|intraspecies interaction with other organisms http://purl.obolibrary.org/obo/GO_0051703 gocheck_do_not_annotate|goslim_pir GO:0051700 biolink:MolecularActivity fructosyl-amino acid oxidase activity Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2. go.json FAOD activity http://purl.obolibrary.org/obo/GO_0051700 GO:0051701 biolink:BiologicalProcess biological process involved in interaction with host An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. go.json growth of symbiont in host|growth of symbiont in host cell|growth of symbiont in host organelle|growth of symbiont in host vacuole|interaction with host http://purl.obolibrary.org/obo/GO_0051701 GO:0051706 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051706 GO:0051707 biolink:BiologicalProcess response to other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. go.json http://purl.obolibrary.org/obo/GO_0051707 GO:0051704 biolink:BiologicalProcess obsolete multi-organism process OBSOLETE. A biological process which involves another organism of the same or different species. go.json interaction between organisms|physiological interaction between organisms|physiological interaction with other organism True http://purl.obolibrary.org/obo/GO_0051704 GO:0051705 biolink:BiologicalProcess obsolete multi-organism behavior OBSOLETE. Any process in which an organism has a behavioral effect on another organism of the same or different species. go.json behavioral interaction between organisms|behavioral interaction with other organism|behavioral signaling|behavioral signalling|behavioural interaction between organisms|behavioural interaction with other organism True http://purl.obolibrary.org/obo/GO_0051705 GO:0120127 biolink:BiologicalProcess response to zinc ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion. go.json http://purl.obolibrary.org/obo/GO_0120127 GO:0051708 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051708 GO:0051709 biolink:BiologicalProcess regulation of killing of cells of another organism Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism. go.json modulation by organism of apoptotic process in other organism involved in symbiotic interaction|modulation of programmed cell death in other organism|modulation of programmed cell death in other organism involved in symbiotic interaction|regulation of killing of cells of other organism http://purl.obolibrary.org/obo/GO_0051709 GO:0120123 biolink:CellularComponent ubiquitin activating enzyme complex A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. go.json E1 complex|E1 ubiquitin-activating enzyme http://purl.obolibrary.org/obo/GO_0120123 GO:0036167 biolink:BiologicalProcess phenotypic switching in response to host A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. go.json http://purl.obolibrary.org/obo/GO_0036167 GO:0036168 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms in response to heat The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature. go.json http://purl.obolibrary.org/obo/GO_0036168 GO:0120124 biolink:CellularComponent membrane fusion priming complex A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes. go.json GATE-16 complex|LMA1 complex http://purl.obolibrary.org/obo/GO_0120124 GO:0120125 biolink:CellularComponent PNGase complex A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. go.json http://purl.obolibrary.org/obo/GO_0120125 GO:0036169 biolink:MolecularActivity 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2. Reactome:R-HSA-2162195 go.json http://purl.obolibrary.org/obo/GO_0036169 GO:0120126 biolink:BiologicalProcess response to copper ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion. go.json http://purl.obolibrary.org/obo/GO_0120126 GO:0120120 biolink:CellularComponent bilobe structure A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). go.json kinetoplastid flagellar hook complex http://purl.obolibrary.org/obo/GO_0120120 GO:0120121 biolink:CellularComponent tripartite attachment complex A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body. go.json TAC http://purl.obolibrary.org/obo/GO_0120121 GO:0120122 biolink:BiologicalProcess prolactin metabolic process The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals. go.json prolactin metabolism http://purl.obolibrary.org/obo/GO_0120122 GO:0036160 biolink:BiologicalProcess melanocyte-stimulating hormone secretion The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation. go.json MSH secretion http://purl.obolibrary.org/obo/GO_0036160 GO:0036161 biolink:BiologicalProcess calcitonin secretion The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell. go.json http://purl.obolibrary.org/obo/GO_0036161 GO:0036162 biolink:BiologicalProcess oxytocin production The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain. go.json oxytocin biosynthesis|oxytocin secretion http://purl.obolibrary.org/obo/GO_0036162 GO:0036163 biolink:MolecularActivity 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2. KEGG_REACTION:R06866|RHEA:44768 go.json http://purl.obolibrary.org/obo/GO_0036163 GO:0036164 biolink:BiologicalProcess cell-abiotic substrate adhesion The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules. go.json cell-abiotic surface adhesion http://purl.obolibrary.org/obo/GO_0036164 GO:0036165 biolink:BiologicalProcess invasive growth in response to heat The growth of colonies in filamentous chains of cells as a result of an increase in temperature. go.json invasive growth in response to elevated temperature|invasive growth in response to high temperature|invasive growth in response to temperature stimulus http://purl.obolibrary.org/obo/GO_0036165 GO:0036166 biolink:BiologicalProcess phenotypic switching A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues. go.json phenotypic dimorphism http://purl.obolibrary.org/obo/GO_0036166 GO:0051710 biolink:BiologicalProcess obsolete regulation of cytolysis in another organism OBSOLETE. Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism. go.json regulation of cytolysis in other organism|regulation of cytolysis of cells of another organism True http://purl.obolibrary.org/obo/GO_0051710 GO:0051713 biolink:BiologicalProcess obsolete negative regulation of cytolysis in another organism OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism. go.json down regulation of cytolysis of cells of another organism|down-regulation of cytolysis of cells of another organism|downregulation of cytolysis of cells of another organism|inhibition of cytolysis of cells of another organism|negative regulation of cytolysis in other organism|negative regulation of cytolysis of cells of another organism True http://purl.obolibrary.org/obo/GO_0051713 GO:0051714 biolink:BiologicalProcess obsolete positive regulation of cytolysis in another organism OBSOLETE. Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism. go.json activation of cytolysis of cells of another organism|positive regulation of cytolysis in other organism|positive regulation of cytolysis of cells of another organism|stimulation of cytolysis of cells of another organism|up regulation of cytolysis of cells of another organism|up-regulation of cytolysis of cells of another organism|upregulation of cytolysis of cells of another organism True http://purl.obolibrary.org/obo/GO_0051714 GO:0051711 biolink:BiologicalProcess negative regulation of killing of cells of another organism Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism. go.json down regulation of killing of cells of another organism|down-regulation of killing of cells of another organism|downregulation of killing of cells of another organism|inhibition of killing of cells of another organism|negative regulation of killing of cells of other organism http://purl.obolibrary.org/obo/GO_0051711 GO:0051712 biolink:BiologicalProcess positive regulation of killing of cells of another organism Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism. go.json activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction|activation of killing of cells of another organism|enhancement of other organism programmed cell death by organism|positive regulation of killing of cells of other organism|stimulation of killing of cells of another organism|up regulation of killing of cells of another organism|up-regulation of killing of cells of another organism|upregulation of killing of cells of another organism http://purl.obolibrary.org/obo/GO_0051712 GO:0051717 biolink:MolecularActivity inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. MetaCyc:3.1.3.62-RXN|Reactome:R-HSA-1855200|Reactome:R-HSA-1855205 go.json inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity|inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity|inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity http://purl.obolibrary.org/obo/GO_0051717 GO:0051718 biolink:MolecularActivity DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). Reactome:R-HSA-5334151 go.json HpaII methylase|HpaII' methylase|M.BsuRIa|M.BsuRIb http://purl.obolibrary.org/obo/GO_0051718 GO:0051715 biolink:BiologicalProcess cytolysis in another organism The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm. go.json cytolysis in other organism|cytolysis of cells of another organism|envenomation resulting in cytolysis in another organism|envenomation resulting in cytolysis in other organism http://purl.obolibrary.org/obo/GO_0051715 GO:0051716 biolink:BiologicalProcess cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. go.json http://purl.obolibrary.org/obo/GO_0051716 gocheck_do_not_manually_annotate GO:0051719 biolink:MolecularActivity DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN. Reactome:R-HSA-5334097|Reactome:R-HSA-5334152 go.json http://purl.obolibrary.org/obo/GO_0051719 GO:0036156 biolink:CellularComponent inner dynein arm Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. go.json inner dynein arm complex http://purl.obolibrary.org/obo/GO_0036156 GO:0036157 biolink:CellularComponent outer dynein arm Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. go.json outer dynein arm complex http://purl.obolibrary.org/obo/GO_0036157 GO:0036158 biolink:BiologicalProcess outer dynein arm assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. go.json ODA assembly http://purl.obolibrary.org/obo/GO_0036158 GO:0036159 biolink:BiologicalProcess inner dynein arm assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. go.json IDA assembly http://purl.obolibrary.org/obo/GO_0036159 GO:0036150 biolink:BiologicalProcess phosphatidylserine acyl-chain remodeling Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. go.json phosphatidyl-L-serine acyl-chain remodeling|phosphatidylserine acyl-chain remodelling http://purl.obolibrary.org/obo/GO_0036150 GO:0036151 biolink:BiologicalProcess phosphatidylcholine acyl-chain remodeling Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. go.json phosphatidylcholine acyl-chain remodelling http://purl.obolibrary.org/obo/GO_0036151 GO:0036152 biolink:BiologicalProcess phosphatidylethanolamine acyl-chain remodeling Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. go.json phosphatidylethanolamine acyl-chain remodelling http://purl.obolibrary.org/obo/GO_0036152 GO:0036153 biolink:BiologicalProcess triglyceride acyl-chain remodeling Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains. go.json triacylglycerol acyl-chain remodeling|triglyceride acyl-chain remodelling http://purl.obolibrary.org/obo/GO_0036153 GO:0036154 biolink:BiologicalProcess diacylglycerol acyl-chain remodeling Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains. go.json diacylglycerol acyl-chain remodelling|diglyceride acyl-chain remodeling http://purl.obolibrary.org/obo/GO_0036154 GO:0036155 biolink:BiologicalProcess acylglycerol acyl-chain remodeling Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains. go.json acylglycerol acyl-chain remodelling|glyceride acyl-chain remodeling http://purl.obolibrary.org/obo/GO_0036155 GO:0051720 biolink:MolecularActivity DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG. go.json http://purl.obolibrary.org/obo/GO_0051720 GO:0051721 biolink:MolecularActivity protein phosphatase 2A binding Binding to protein phosphatase 2A. go.json protein phosphatase 2 binding http://purl.obolibrary.org/obo/GO_0051721 GO:0051724 biolink:MolecularActivity NAD transmembrane transporter activity Enables the transfer of NAD from one side of a membrane to the other. go.json NAD (oxidized) transporter activity|NAD (reduced) transporter activity|NAD transporter activity|NAD+ transporter activity|NADH transporter activity|nicotinamide adenine dinucleotide transmembrane transporter activity|oxidized NAD transporter activity|oxidized nicotinamide adenine dinucleotide transmembrane transporter activity|reduced NAD transporter activity|reduced nicotinamide adenine dinucleotide transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0051724 GO:0051725 biolink:BiologicalProcess protein de-ADP-ribosylation The process of removing one or more ADP-ribose residues from a protein. go.json poly(ADP-ribose) removal from protein|protein amino acid de-ADP-ribosylation|protein poly(ADP-ribose) catabolic process|protein poly(ADP-ribose) catabolism|protein poly(ADP-ribose) degradation|protein poly(ADP-ribose) hydrolysis|removal of ADP-ribose from protein http://purl.obolibrary.org/obo/GO_0051725 gocheck_do_not_annotate GO:0051722 biolink:MolecularActivity protein C-terminal methylesterase activity Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. Reactome:R-HSA-8856951 go.json protein phosphatase methylesterase activity http://purl.obolibrary.org/obo/GO_0051722 GO:0051723 biolink:MolecularActivity protein methylesterase activity Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. Reactome:R-HSA-5367022 go.json PME activity|protein carboxyl methylesterase activity|protein carboxylic ester hydrolase activity|protein methyl-esterase activity http://purl.obolibrary.org/obo/GO_0051723 GO:0051728 biolink:BiologicalProcess cell cycle switching, mitotic to meiotic cell cycle The process in which a cell switches cell cycle mode from mitotic to meiotic division. go.json cell cycle switching, mitosis to meiosis|conversion to meiosis|conversion to meiotic cell cycle|entry into meiosis|entry into meiotic cell cycle|initiation of meiosis|initiation of meiotic cell cycle|meiotic entry http://purl.obolibrary.org/obo/GO_0051728 GO:0051729 biolink:BiologicalProcess germline cell cycle switching, mitotic to meiotic cell cycle The process in which a germline cell switches cell cycle mode from mitotic to meiotic division. go.json germline cell cycle switching, mitosis to meiosis|germline conversion to meiosis|germline conversion to meiotic cell cycle|germline entry into meiosis|germline entry into meiotic cell cycle|germline initiation of meiosis|germline initiation of meiotic cell cycle|germline meiotic entry http://purl.obolibrary.org/obo/GO_0051729 GO:0051726 biolink:BiologicalProcess regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle. go.json arrest of mitotic cell cycle progression|cell cycle arrest|cell cycle modulation|cell cycle regulation|cell cycle regulator|control of cell cycle progression|mitotic cell cycle arrest|modulation of cell cycle progression|negative regulation of cell cycle arrest|positive regulation of cell cycle arrest|regulation of cell cycle arrest|regulation of cell cycle progression|regulation of progression through cell cycle|tumor suppressor http://purl.obolibrary.org/obo/GO_0051726 goslim_yeast GO:0051727 biolink:BiologicalProcess obsolete cell cycle switching, meiotic to mitotic cell cycle OBSOLETE. The process in which a cell switches cell cycle mode from meiotic to mitotic division. go.json cell cycle switching, meiosis to mitosis|cell cycle switching, meiotic to mitotic cell cycle|conversion to mitosis|conversion to mitotic cell cycle|entry into mitosis|entry into mitotic cell cycle|initiation of mitosis|initiation of mitotic cell cycle|mitotic entry True http://purl.obolibrary.org/obo/GO_0051727 GO:0036145 biolink:BiologicalProcess dendritic cell homeostasis The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json DC homeostasis http://purl.obolibrary.org/obo/GO_0036145 GO:0036146 biolink:BiologicalProcess cellular response to mycotoxin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi. go.json http://purl.obolibrary.org/obo/GO_0036146 GO:0036147 biolink:BiologicalProcess rumination A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again. go.json digestive rumination http://purl.obolibrary.org/obo/GO_0036147 GO:0036148 biolink:BiologicalProcess phosphatidylglycerol acyl-chain remodeling Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. go.json phosphatidylglycerol acyl-chain remodelling http://purl.obolibrary.org/obo/GO_0036148 GO:0036149 biolink:BiologicalProcess phosphatidylinositol acyl-chain remodeling Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. go.json phosphatidylinositol acyl-chain remodelling http://purl.obolibrary.org/obo/GO_0036149 GO:0036140 biolink:MolecularActivity [protein]-asparagine 3-dioxygenase activity Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2. RHEA:54260 go.json hypoxia-inducible factor-asparagine oxygenase activity|peptidyl-asparagine 3-dioxygenase activity http://purl.obolibrary.org/obo/GO_0036140 GO:0036141 biolink:MolecularActivity L-phenylalanine-oxaloacetate transaminase activity Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate. go.json L-phenylalanine:oxaloacetate transaminase activity http://purl.obolibrary.org/obo/GO_0036141 GO:0036142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036142 GO:0036143 biolink:MolecularActivity kringle domain binding Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. go.json http://purl.obolibrary.org/obo/GO_0036143 GO:0036144 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036144 GO:0051731 biolink:MolecularActivity polynucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. go.json 5'-dephosphopolynucleotide kinase activity|5'-hydroxyl polynucleotide kinase activity|PNK|polynucleotide 5'-hydroxy-kinase activity|polynucleotide 5'-hydroxyl kinase (phosphorylating) activity|polynucleotide kinase activity http://purl.obolibrary.org/obo/GO_0051731 GO:0051732 biolink:MolecularActivity obsolete polyribonucleotide kinase activity OBSOLETE. Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA. go.json 5'-hydroxyl RNA kinase activity|5'-hydroxyl polyribonucleotide kinase activity|RNA 5'-hydroxyl kinase activity|RNA kinase activity True http://purl.obolibrary.org/obo/GO_0051732 GO:0051730 biolink:MolecularActivity GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA. go.json GTP-dependent RNA 5'-hydroxyl-kinase activity|GTP-dependent RNA kinase activity|GTP-dependent polyribonucleotide kinase activity http://purl.obolibrary.org/obo/GO_0051730 GO:0051735 biolink:MolecularActivity GTP-dependent polynucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. go.json GTP-dependent polynucleotide kinase activity http://purl.obolibrary.org/obo/GO_0051735 GO:0051736 biolink:MolecularActivity ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA. RHEA:54580 go.json ATP-dependent RNA kinase activity|ATP-dependent polyribonucleotide kinase activity|polyribonucleotide 5'-hydroxyl-kinase activity http://purl.obolibrary.org/obo/GO_0051736 GO:0051733 biolink:MolecularActivity obsolete polydeoxyribonucleotide kinase activity OBSOLETE. Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA. go.json DNA 5'-hydroxyl kinase activity|DNA kinase activity True http://purl.obolibrary.org/obo/GO_0051733 GO:0075705 biolink:BiologicalProcess obsolete viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane OBSOLETE. The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when the viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane. go.json viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane|viral penetration via endocytosis followed by genetic injection through the endosome membrane True http://purl.obolibrary.org/obo/GO_0075705 GO:0051734 biolink:MolecularActivity ATP-dependent polynucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. EC:2.7.1.78 go.json ATP-dependent polynucleotide kinase activity|polynucleotide kinase activity http://purl.obolibrary.org/obo/GO_0051734 GO:0075706 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075706 GO:0051739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051739 GO:0051737 biolink:MolecularActivity GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA. go.json GTP-dependent DNA 5'-hydroxyl-kinase activity|GTP-dependent DNA kinase activity|GTP-dependent polydeoxyribonucleotide kinase activity http://purl.obolibrary.org/obo/GO_0051737 GO:0051738 biolink:MolecularActivity xanthophyll binding Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen. go.json http://purl.obolibrary.org/obo/GO_0051738 GO:0036134 biolink:MolecularActivity 12-hydroxyheptadecatrienoic acid synthase activity Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA). RHEA:48644|Reactome:R-HSA-2161613 go.json prostaglandin H2 degradation activity http://purl.obolibrary.org/obo/GO_0036134 GO:0036135 biolink:BiologicalProcess Schwann cell migration The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function. go.json http://purl.obolibrary.org/obo/GO_0036135 GO:0036136 biolink:MolecularActivity kynurenine-oxaloacetate transaminase activity Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate. go.json L-kynurenine-oxaloacetate transaminase activity http://purl.obolibrary.org/obo/GO_0036136 GO:0036137 biolink:MolecularActivity kynurenine aminotransferase activity Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid. go.json L-kynurenine transaminase activity|kynurenine-oxo-acid transaminase activity http://purl.obolibrary.org/obo/GO_0036137 GO:0036138 biolink:BiologicalProcess peptidyl-histidine hydroxylation The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine. go.json http://purl.obolibrary.org/obo/GO_0036138 gocheck_do_not_annotate GO:0036139 biolink:MolecularActivity peptidyl-histidine dioxygenase activity Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2. Reactome:R-HSA-9630967|Reactome:R-HSA-9630993 go.json http://purl.obolibrary.org/obo/GO_0036139 GO:0036130 biolink:MolecularActivity prostaglandin H2 endoperoxidase reductase activity Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate). KEGG_REACTION:R02264|RHEA:45312|Reactome:R-HSA-2161549 go.json PGH2 9,11-endoperoxidase|PGH2 9-,11-endoperoxide reductase http://purl.obolibrary.org/obo/GO_0036130 GO:0036131 biolink:MolecularActivity prostaglandin D2 11-ketoreductase activity Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+. EC:1.1.1.188|KEGG_REACTION:R02799|RHEA:45316|Reactome:R-HSA-2161614 go.json PGD2 11-ketoreductase|prostaglandin 11-keto reductase http://purl.obolibrary.org/obo/GO_0036131 GO:0036132 biolink:MolecularActivity 13-prostaglandin reductase activity Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin. EC:1.3.1.48|KEGG_REACTION:R04556|KEGG_REACTION:R04557|Reactome:R-HSA-2161692 go.json 15-ketoprostaglandin delta13-reductase activity|15-oxo-delta13-prostaglandin reductase activity|15-oxoprostaglandin 13-reductase activity|delta13-15-ketoprostaglandin reductase activity|prostaglandin 13-reductase activity|prostaglandin delta13-reductase activity http://purl.obolibrary.org/obo/GO_0036132 GO:0036133 biolink:MolecularActivity 11-hydroxythromboxane B2 dehydrogenase activity Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+. KEGG_REACTION:R05060|RHEA:52312|Reactome:R-HSA-2161732 go.json NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity http://purl.obolibrary.org/obo/GO_0036133 GO:0051742 biolink:MolecularActivity 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine. MetaCyc:RXN-2762|RHEA:37999 go.json MSBQ methyltransferase activity http://purl.obolibrary.org/obo/GO_0051742 GO:0051743 biolink:MolecularActivity red chlorophyll catabolite reductase activity Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence. MetaCyc:RXN-7741|RHEA:24752 go.json RCC reductase activity http://purl.obolibrary.org/obo/GO_0051743 GO:0051740 biolink:MolecularActivity ethylene binding Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. go.json ethene binding http://purl.obolibrary.org/obo/GO_0051740 GO:0051741 biolink:MolecularActivity 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine. MetaCyc:RXN-2542|RHEA:37979 go.json MPBQ methyltransferase activity http://purl.obolibrary.org/obo/GO_0051741 GO:0051746 biolink:MolecularActivity thalianol synthase activity Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol). EC:5.4.99.31|RHEA:26160 go.json http://purl.obolibrary.org/obo/GO_0051746 GO:0051747 biolink:MolecularActivity cytosine C-5 DNA demethylase activity Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. go.json DNA demethylase activity|DNA methyltransferase activity acting on cytosine C-5|hydrolytic DNA demethylase activity http://purl.obolibrary.org/obo/GO_0051747 GO:0051744 biolink:MolecularActivity 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+. MetaCyc:RXN1F-72|RHEA:48884 go.json http://purl.obolibrary.org/obo/GO_0051744 GO:0051745 biolink:MolecularActivity 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. EC:1.17.7.4|MetaCyc:ISPH2-RXN go.json 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity|isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0051745 GO:0051748 biolink:MolecularActivity UTP-monosaccharide-1-phosphate uridylyltransferase activity Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide. EC:2.7.7.64|MetaCyc:2.7.7.64-RXN|RHEA:13205 go.json PsUSP|UDP-monosaccharide diphosphorylase activity|UDP-monosaccharide pyrophosphorylase activity|UDP-sugar pyrophosphorylase activity|USP http://purl.obolibrary.org/obo/GO_0051748 GO:0051749 biolink:MolecularActivity indole acetic acid carboxyl methyltransferase activity Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine. go.json IAA carboxyl methyltransferase activity http://purl.obolibrary.org/obo/GO_0051749 GO:0036123 biolink:BiologicalProcess histone H3-K9 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone. go.json histone H3 K9 dimethylation|histone lysine H3 K9 dimethylation http://purl.obolibrary.org/obo/GO_0036123 gocheck_do_not_annotate GO:0036124 biolink:BiologicalProcess histone H3-K9 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone. go.json http://purl.obolibrary.org/obo/GO_0036124 gocheck_do_not_annotate GO:0036125 biolink:CellularComponent fatty acid beta-oxidation multienzyme complex A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT). go.json http://purl.obolibrary.org/obo/GO_0036125 GO:0036126 biolink:CellularComponent sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. go.json sperm cilium|sperm tail http://purl.obolibrary.org/obo/GO_0036126 GO:0036127 biolink:MolecularActivity 3-sulfino-L-alanine binding Binding to 3-sulfino-L-alanine (cysteine sulfinate). go.json cysteine sulfinate binding http://purl.obolibrary.org/obo/GO_0036127 GO:0036128 biolink:CellularComponent CatSper complex A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits. go.json CATSPER channel|CatSper channel complex http://purl.obolibrary.org/obo/GO_0036128 GO:0036129 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus. go.json True http://purl.obolibrary.org/obo/GO_0036129 GO:0036120 biolink:BiologicalProcess cellular response to platelet-derived growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. go.json cellular response to PDGF stimulus http://purl.obolibrary.org/obo/GO_0036120 GO:0036121 biolink:MolecularActivity double-stranded DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix. go.json double-stranded DNA-dependent ATP-dependent DNA helicase activity|double-stranded DNA-dependent ATPase activity|dsDNA-dependent ATP-dependent DNA helicase activity|dsDNA-dependent ATPase activity http://purl.obolibrary.org/obo/GO_0036121 GO:0036122 biolink:MolecularActivity BMP binding Binding to a member of the bone morphogenetic protein (BMP) family. go.json bone morphogenetic protein binding http://purl.obolibrary.org/obo/GO_0036122 GO:0002908 biolink:BiologicalProcess regulation of peripheral B cell deletion Any process that modulates the frequency, rate, or extent of peripheral B cell deletion. go.json http://purl.obolibrary.org/obo/GO_0002908 GO:0002909 biolink:BiologicalProcess negative regulation of peripheral B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion. go.json down regulation of peripheral B cell deletion|down-regulation of peripheral B cell deletion|downregulation of peripheral B cell deletion|inhibition of peripheral B cell deletion http://purl.obolibrary.org/obo/GO_0002909 GO:0002904 biolink:BiologicalProcess positive regulation of B cell apoptotic process Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process. go.json activation of B cell apoptosis|positive regulation of B cell apoptosis|stimulation of B cell apoptosis|up regulation of B cell apoptosis|up-regulation of B cell apoptosis|upregulation of B cell apoptosis http://purl.obolibrary.org/obo/GO_0002904 GO:0002905 biolink:BiologicalProcess regulation of mature B cell apoptotic process Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process. go.json regulation of mature B cell apoptosis http://purl.obolibrary.org/obo/GO_0002905 GO:0002906 biolink:BiologicalProcess negative regulation of mature B cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process. go.json down regulation of mature B cell apoptosis|down-regulation of mature B cell apoptosis|downregulation of mature B cell apoptosis|inhibition of mature B cell apoptosis|negative regulation of mature B cell apoptosis http://purl.obolibrary.org/obo/GO_0002906 GO:0002907 biolink:BiologicalProcess positive regulation of mature B cell apoptotic process Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process. go.json activation of mature B cell apoptosis|positive regulation of mature B cell apoptosis|stimulation of mature B cell apoptosis|up regulation of mature B cell apoptosis|up-regulation of mature B cell apoptosis|upregulation of mature B cell apoptosis http://purl.obolibrary.org/obo/GO_0002907 GO:0002900 biolink:BiologicalProcess positive regulation of central B cell deletion Any process that activates or increases the frequency, rate, or extent of central B cell deletion. go.json activation of central B cell deletion|stimulation of central B cell deletion|up regulation of central B cell deletion|up-regulation of central B cell deletion|upregulation of central B cell deletion http://purl.obolibrary.org/obo/GO_0002900 GO:0002901 biolink:BiologicalProcess mature B cell apoptotic process Any apoptotic process in a B cell that is mature, having left the bone marrow. go.json apoptosis of mature B cells|apoptosis of mature B lymphocytes|apoptosis of mature B-cells|apoptosis of mature B-lymphocytes|mature B cell apoptosis|mature B cell programmed cell death by apoptosis|mature B lymphocyte apoptosis|mature B lymphocyte programmed cell death by apoptosis|mature B-cell apoptosis|mature B-cell programmed cell death by apoptosis|mature B-lymphocyte apoptosis|mature B-lymphocyte programmed cell death by apoptosis|programmed cell death of mature B cells by apoptosis|programmed cell death of mature B lymphocytes by apoptosis|programmed cell death of mature B-cells by apoptosis|programmed cell death of mature B-lymphocytes by apoptosis|programmed cell death, mature B cells|programmed cell death, mature B lymphocytes|programmed cell death, mature B-cells|programmed cell death, mature B-lymphocytes http://purl.obolibrary.org/obo/GO_0002901 GO:0002902 biolink:BiologicalProcess regulation of B cell apoptotic process Any process that modulates the frequency, rate, or extent of B cell apoptotic process. go.json regulation of B cell apoptosis http://purl.obolibrary.org/obo/GO_0002902 GO:0002903 biolink:BiologicalProcess negative regulation of B cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. go.json down regulation of B cell apoptosis|down-regulation of B cell apoptosis|downregulation of B cell apoptosis|inhibition of B cell apoptosis|negative regulation of B cell apoptosis http://purl.obolibrary.org/obo/GO_0002903 GO:0002910 biolink:BiologicalProcess positive regulation of peripheral B cell deletion Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion. go.json activation of peripheral B cell deletion|stimulation of peripheral B cell deletion|up regulation of peripheral B cell deletion|up-regulation of peripheral B cell deletion|upregulation of peripheral B cell deletion http://purl.obolibrary.org/obo/GO_0002910 GO:0002919 biolink:BiologicalProcess positive regulation of peripheral B cell anergy Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy. go.json activation of peripheral B cell anergy|stimulation of peripheral B cell anergy|up regulation of peripheral B cell anergy|up-regulation of peripheral B cell anergy|upregulation of peripheral B cell anergy http://purl.obolibrary.org/obo/GO_0002919 GO:0002915 biolink:BiologicalProcess negative regulation of central B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy. go.json down regulation of central B cell anergy|down-regulation of central B cell anergy|downregulation of central B cell anergy|inhibition of central B cell anergy http://purl.obolibrary.org/obo/GO_0002915 GO:0002916 biolink:BiologicalProcess positive regulation of central B cell anergy Any process that activates or increases the frequency, rate, or extent of central B cell anergy. go.json activation of central B cell anergy|stimulation of central B cell anergy|up regulation of central B cell anergy|up-regulation of central B cell anergy|upregulation of central B cell anergy http://purl.obolibrary.org/obo/GO_0002916 GO:0002917 biolink:BiologicalProcess regulation of peripheral B cell anergy Any process that modulates the frequency, rate, or extent of peripheral B cell anergy. go.json http://purl.obolibrary.org/obo/GO_0002917 GO:0002918 biolink:BiologicalProcess negative regulation of peripheral B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy. go.json down regulation of peripheral B cell anergy|down-regulation of peripheral B cell anergy|downregulation of peripheral B cell anergy|inhibition of peripheral B cell anergy http://purl.obolibrary.org/obo/GO_0002918 GO:0002911 biolink:BiologicalProcess regulation of lymphocyte anergy Any process that modulates the frequency, rate, or extent of lymphocyte anergy. go.json http://purl.obolibrary.org/obo/GO_0002911 GO:0002912 biolink:BiologicalProcess negative regulation of lymphocyte anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy. go.json down regulation of lymphocyte anergy|down-regulation of lymphocyte anergy|downregulation of lymphocyte anergy|inhibition of lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002912 GO:0002913 biolink:BiologicalProcess positive regulation of lymphocyte anergy Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy. go.json activation of lymphocyte anergy|stimulation of lymphocyte anergy|up regulation of lymphocyte anergy|up-regulation of lymphocyte anergy|upregulation of lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002913 GO:0002914 biolink:BiologicalProcess regulation of central B cell anergy Any process that modulates the frequency, rate, or extent of central B cell anergy. go.json http://purl.obolibrary.org/obo/GO_0002914 GO:0051900 biolink:BiologicalProcess regulation of mitochondrial depolarization Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. go.json http://purl.obolibrary.org/obo/GO_0051900 GO:0051901 biolink:BiologicalProcess positive regulation of mitochondrial depolarization Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. go.json activation of mitochondrial depolarization|stimulation of mitochondrial depolarization|up regulation of mitochondrial depolarization|up-regulation of mitochondrial depolarization|upregulation of mitochondrial depolarization http://purl.obolibrary.org/obo/GO_0051901 GO:0051904 biolink:BiologicalProcess pigment granule transport The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json pigment granule translocation http://purl.obolibrary.org/obo/GO_0051904 GO:0051905 biolink:BiologicalProcess establishment of pigment granule localization The directed movement of a pigment granule to a specific location. go.json establishment of pigment granule localisation http://purl.obolibrary.org/obo/GO_0051905 GO:0051902 biolink:BiologicalProcess negative regulation of mitochondrial depolarization Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. go.json down regulation of mitochondrial depolarization|down-regulation of mitochondrial depolarization|downregulation of mitochondrial depolarization|inhibition of mitochondrial depolarization http://purl.obolibrary.org/obo/GO_0051902 GO:0051903 biolink:MolecularActivity S-(hydroxymethyl)glutathione dehydrogenase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. EC:1.1.1.284|KEGG_REACTION:R06983|KEGG_REACTION:R07140|MetaCyc:RXN-2962|Reactome:R-HSA-5692237|UM-BBD_reactionID:r1146 go.json ADH3 activity|FDH activity|GD-FALDH activity|GS-FDH activity|NAD- and glutathione-dependent formaldehyde dehydrogenase activity|NAD-dependent formaldehyde dehydrogenase activity|NAD-linked formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity|chi-ADH activity|class III alcohol dehydrogenase activity|formic dehydrogenase activity|glutathione-dependent formaldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0051903 GO:0051908 biolink:MolecularActivity double-stranded DNA 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. go.json double-stranded DNA specific 5'-3' exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0051908 GO:0051909 biolink:MolecularActivity acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O. EC:4.2.1.27 go.json 3-hydroxypropenoate dehydratase activity|acetylenecarboxylate hydratase activity|acetylenemonocarboxylate hydratase activity|alkynoate hydratase activity http://purl.obolibrary.org/obo/GO_0051909 GO:0051906 biolink:BiologicalProcess maintenance of pigment granule location Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere. go.json maintenance of pigment granule localization http://purl.obolibrary.org/obo/GO_0051906 GO:0051907 biolink:MolecularActivity S-(hydroxymethyl)glutathione synthase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione. EC:4.4.1.22|KEGG_REACTION:R06982|MetaCyc:RXN-2961|RHEA:22488|UM-BBD_reactionID:r1145 go.json Gfa|S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)|S-(hydroxymethyl)glutathione formaldehyde-lyase activity|glutathione-dependent formaldehyde-activating enzyme activity http://purl.obolibrary.org/obo/GO_0051907 GO:0061280 biolink:BiologicalProcess epithelial cell migration involved in mesonephric proximal tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0061280 GO:0061281 biolink:BiologicalProcess specification of mesonephric connecting tubule identity The process in which the connecting tubule of the mesonephric nephron acquires its identity. go.json specification of mesonephric collecting tubule identity http://purl.obolibrary.org/obo/GO_0061281 GO:0061282 biolink:BiologicalProcess specification of mesonephric nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0061282 GO:0061283 biolink:BiologicalProcess specification of mesonephric distal tubule identity The process in which the distal tubule of the mesonephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0061283 GO:0061284 biolink:BiologicalProcess specification of mesonephric proximal tubule identity The process in which the proximal tubule of the mesonephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0061284 GO:0061285 biolink:BiologicalProcess mesonephric capsule development The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. go.json http://purl.obolibrary.org/obo/GO_0061285 GO:0061286 biolink:BiologicalProcess mesonephric capsule morphogenesis The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. go.json http://purl.obolibrary.org/obo/GO_0061286 GO:0061287 biolink:BiologicalProcess mesonephric capsule formation The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. go.json http://purl.obolibrary.org/obo/GO_0061287 GO:0061288 biolink:BiologicalProcess mesonephric capsule specification The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0061288 GO:0061289 biolink:BiologicalProcess Wnt signaling pathway involved in kidney development The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time. go.json Wnt receptor signaling pathway involved in kidney development|Wnt receptor signalling pathway involved in kidney development|Wnt-activated signaling pathway involved in kidney development http://purl.obolibrary.org/obo/GO_0061289 GO:0061270 biolink:BiologicalProcess mesonephric intraglomerular mesangial cell proliferation The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0061270 GO:0061271 biolink:BiologicalProcess mesenchymal to epithelial transition involved in mesonephric renal vesicle formation A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle. go.json http://purl.obolibrary.org/obo/GO_0061271 GO:0061272 biolink:BiologicalProcess mesonephric connecting tubule development The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros. go.json mesonephric collecting tubule development|mesonephric connecting duct development http://purl.obolibrary.org/obo/GO_0061272 GO:0061273 biolink:BiologicalProcess mesonephric distal tubule morphogenesis The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule. go.json http://purl.obolibrary.org/obo/GO_0061273 GO:0061274 biolink:BiologicalProcess mesonephric distal tubule development The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule. go.json http://purl.obolibrary.org/obo/GO_0061274 GO:0061275 biolink:BiologicalProcess mesonephric proximal tubule development The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule. go.json http://purl.obolibrary.org/obo/GO_0061275 GO:0061276 biolink:BiologicalProcess mesonephric proximal tubule morphogenesis The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule. go.json http://purl.obolibrary.org/obo/GO_0061276 GO:0061277 biolink:BiologicalProcess mesonephric nephron tubule formation The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061277 GO:0061278 biolink:BiologicalProcess epithelial cell migration involved in mesonephric nephron tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0061278 GO:0061279 biolink:BiologicalProcess epithelial cell migration involved in mesonephric distal tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0061279 GO:0061290 biolink:BiologicalProcess canonical Wnt signaling pathway involved in metanephric kidney development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json canonical Wnt receptor signaling pathway involved in metanephric kidney development|canonical Wnt receptor signalling pathway involved in metanephric kidney development|canonical Wnt-activated signaling pathway involved in metanephric kidney development http://purl.obolibrary.org/obo/GO_0061290 GO:0061291 biolink:BiologicalProcess canonical Wnt signaling pathway involved in ureteric bud branching The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json canonical Wnt receptor signaling pathway involved in ureteric bud branching|canonical Wnt receptor signalling pathway involved in ureteric bud branching http://purl.obolibrary.org/obo/GO_0061291 GO:0061292 biolink:BiologicalProcess canonical Wnt signaling pathway involved in mesonephros development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json canonical Wnt receptor signaling pathway involved in mesonephros development|canonical Wnt receptor signalling pathway involved in mesonephros development|canonical Wnt-activated signaling pathway involved in mesonephros development http://purl.obolibrary.org/obo/GO_0061292 GO:0061293 biolink:BiologicalProcess canonical Wnt signaling pathway involved in mesonephric nephron development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json canonical Wnt receptor signaling pathway involved in mesonephric nephron development|canonical Wnt receptor signalling pathway involved in mesonephric nephron development|canonical Wnt-activated signaling pathway involved in mesonephric nephron development http://purl.obolibrary.org/obo/GO_0061293 GO:0061294 biolink:BiologicalProcess mesonephric renal vesicle induction Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle. go.json http://purl.obolibrary.org/obo/GO_0061294 GO:0061295 biolink:BiologicalProcess regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. go.json regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis|regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0061295 GO:0061296 biolink:BiologicalProcess negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. go.json negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis|negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0061296 GO:0061297 biolink:BiologicalProcess positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. go.json positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis|positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0061297 GO:0061298 biolink:BiologicalProcess retina vasculature development in camera-type eye The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. go.json retinal vasculature development http://purl.obolibrary.org/obo/GO_0061298 GO:0061299 biolink:BiologicalProcess retina vasculature morphogenesis in camera-type eye The process in which the vasculature of the retina is generated and organized. go.json retinal vasculature morphogenesis http://purl.obolibrary.org/obo/GO_0061299 GO:0002940 biolink:BiologicalProcess tRNA N2-guanine methylation The process whereby a guanine in a tRNA is methylated at the N2 position of guanine. go.json tRNA m2-guanine biosynthesis http://purl.obolibrary.org/obo/GO_0002940 GO:0002941 biolink:BiologicalProcess synoviocyte proliferation The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues. go.json http://purl.obolibrary.org/obo/GO_0002941 GO:0002942 biolink:BiologicalProcess tRNA m2,2-guanine biosynthesis The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position. go.json http://purl.obolibrary.org/obo/GO_0002942 GO:0002943 biolink:BiologicalProcess tRNA dihydrouridine synthesis The process whereby a uridine in a transfer RNA is converted to dihydrouridine. go.json http://purl.obolibrary.org/obo/GO_0002943 GO:0002948 biolink:MolecularActivity archaeosine synthase activity Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA. EC:2.6.1.97|RHEA:54084|Wikipedia:Archaeosine_synthase go.json ArcS|glutamine:preQ0-tRNA amidinotransferase http://purl.obolibrary.org/obo/GO_0002948 GO:0002949 biolink:BiologicalProcess tRNA threonylcarbamoyladenosine modification The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). go.json t6A biosynthesis|t6A biosynthetic process|t6A tRNA modification|threonylcarbamoyladenosine anabolism|threonylcarbamoyladenosine biosynthesis|threonylcarbamoyladenosine biosynthetic process|threonylcarbamoyladenosine formation|threonylcarbamoyladenosine synthesis http://purl.obolibrary.org/obo/GO_0002949 GO:0002944 biolink:CellularComponent cyclin K-CDK12 complex A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json CycK/Cdk12 complex http://purl.obolibrary.org/obo/GO_0002944 GO:0002945 biolink:CellularComponent cyclin K-CDK13 complex A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json CycK/Cdk13 complex http://purl.obolibrary.org/obo/GO_0002945 GO:0002946 biolink:BiologicalProcess tRNA C5-cytosine methylation The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine. go.json tRNA 5-methylcytosine biosynthesis http://purl.obolibrary.org/obo/GO_0002946 GO:0002947 biolink:CellularComponent tumor necrosis factor receptor superfamily complex A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily. go.json TNF receptor superfamily complex http://purl.obolibrary.org/obo/GO_0002947 GO:0002951 biolink:MolecularActivity leukotriene-C(4) hydrolase Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate. EC:3.4.19.14|RHEA:31563 go.json http://purl.obolibrary.org/obo/GO_0002951 GO:0002952 biolink:MolecularActivity (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione. go.json phospho-AI-2 isomerase activity http://purl.obolibrary.org/obo/GO_0002952 GO:0002953 biolink:MolecularActivity 5'-deoxynucleotidase activity Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate. go.json http://purl.obolibrary.org/obo/GO_0002953 GO:0002950 biolink:MolecularActivity ceramide phosphoethanolamine synthase activity Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine. EC:2.7.8.n3|Reactome:R-HSA-8959462 go.json http://purl.obolibrary.org/obo/GO_0002950 GO:0002920 biolink:BiologicalProcess regulation of humoral immune response Any process that modulates the frequency, rate, or extent of a humoral immune response. go.json http://purl.obolibrary.org/obo/GO_0002920 GO:0002921 biolink:BiologicalProcess negative regulation of humoral immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. go.json down regulation of humoral immune response|down-regulation of humoral immune response|downregulation of humoral immune response|inhibition of humoral immune response http://purl.obolibrary.org/obo/GO_0002921 GO:0002926 biolink:BiologicalProcess tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine. go.json mcm5 modification|mcm5s2U34 biosynthesis|tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis http://purl.obolibrary.org/obo/GO_0002926 GO:0002927 biolink:BiologicalProcess archaeosine-tRNA biosynthetic process The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs. go.json http://purl.obolibrary.org/obo/GO_0002927 GO:0002928 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002928 GO:0002929 biolink:CellularComponent MECO complex A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II. go.json meta-coactivator complex http://purl.obolibrary.org/obo/GO_0002929 GO:0002922 biolink:BiologicalProcess positive regulation of humoral immune response Any process that activates or increases the frequency, rate, or extent of a humoral immune response. go.json activation of humoral immune response|stimulation of humoral immune response|up regulation of humoral immune response|up-regulation of humoral immune response|upregulation of humoral immune response http://purl.obolibrary.org/obo/GO_0002922 GO:0002923 biolink:BiologicalProcess regulation of humoral immune response mediated by circulating immunoglobulin Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. go.json http://purl.obolibrary.org/obo/GO_0002923 GO:0002924 biolink:BiologicalProcess negative regulation of humoral immune response mediated by circulating immunoglobulin Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. go.json down regulation of humoral immune response mediated by circulating immunoglobulin|down-regulation of humoral immune response mediated by circulating immunoglobulin|downregulation of humoral immune response mediated by circulating immunoglobulin|inhibition of humoral immune response mediated by circulating immunoglobulin http://purl.obolibrary.org/obo/GO_0002924 GO:0002925 biolink:BiologicalProcess positive regulation of humoral immune response mediated by circulating immunoglobulin Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. go.json activation of humoral immune response mediated by circulating immunoglobulin|stimulation of humoral immune response mediated by circulating immunoglobulin|up regulation of humoral immune response mediated by circulating immunoglobulin|up-regulation of humoral immune response mediated by circulating immunoglobulin|upregulation of humoral immune response mediated by circulating immunoglobulin http://purl.obolibrary.org/obo/GO_0002925 GO:0002930 biolink:BiologicalProcess trabecular meshwork development The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor. go.json http://purl.obolibrary.org/obo/GO_0002930 GO:0002931 biolink:BiologicalProcess response to ischemia Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. go.json http://purl.obolibrary.org/obo/GO_0002931 GO:0002932 biolink:BiologicalProcess tendon sheath development The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. go.json http://purl.obolibrary.org/obo/GO_0002932 GO:0002937 biolink:BiologicalProcess tRNA 4-thiouridine biosynthesis The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs. go.json http://purl.obolibrary.org/obo/GO_0002937 GO:0002938 biolink:BiologicalProcess tRNA guanine ribose methylation The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety. go.json http://purl.obolibrary.org/obo/GO_0002938 GO:0002939 biolink:BiologicalProcess tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine. go.json tRNA m1-guanine biosynthesis http://purl.obolibrary.org/obo/GO_0002939 GO:0002933 biolink:BiologicalProcess lipid hydroxylation The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. go.json fatty acid hydroxylation http://purl.obolibrary.org/obo/GO_0002933 GO:0002934 biolink:BiologicalProcess desmosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0002934 GO:0002935 biolink:MolecularActivity tRNA (adenine(37)-C2)-methyltransferase activity Catalysis of the reaction: adenosine37 in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine37 in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine. EC:2.1.1.192|MetaCyc:RXN0-7007|RHEA:43332 go.json tRNA (adenine(37)-C(2))-methyltransferase activity|tRNA (adenosine(37)-C2-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0002935 GO:0002936 biolink:BiologicalProcess bradykinin biosynthetic process The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin. go.json http://purl.obolibrary.org/obo/GO_0002936 GO:0051874 biolink:BiologicalProcess sphinganine-1-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. go.json dihydrosphingosine-1-phosphate catabolic process|dihydrosphingosine-1-phosphate catabolism http://purl.obolibrary.org/obo/GO_0051874 GO:0051875 biolink:BiologicalProcess pigment granule localization Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. go.json pigment granule localisation http://purl.obolibrary.org/obo/GO_0051875 GO:0051872 biolink:BiologicalProcess sphingosine catabolic process The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. go.json (4E)-sphing-4-enine catabolic process|(4E)-sphing-4-enine catabolism|sphing-4-enine catabolic process|sphing-4-enine catabolism http://purl.obolibrary.org/obo/GO_0051872 GO:0051873 biolink:BiologicalProcess killing by host of symbiont cells Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json disruption by host of symbiont cells http://purl.obolibrary.org/obo/GO_0051873 GO:0051878 biolink:BiologicalProcess lateral element assembly The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements. go.json http://purl.obolibrary.org/obo/GO_0051878 GO:0051879 biolink:MolecularActivity Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. go.json Hsp90 binding|Hsp90 class protein binding http://purl.obolibrary.org/obo/GO_0051879 GO:0051876 biolink:BiologicalProcess pigment granule dispersal The directed movement of pigment granules within a cell towards the cell periphery. go.json http://purl.obolibrary.org/obo/GO_0051876 GO:0051877 biolink:BiologicalProcess pigment granule aggregation in cell center The directed movement of dispersed pigment granules towards the center of the cell. go.json http://purl.obolibrary.org/obo/GO_0051877 GO:0061200 biolink:CellularComponent clathrin-sculpted gamma-aminobutyric acid transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle. go.json clathrin sculpted GABA transport vesicle|clathrin sculpted gamma-aminobutyric acid transport vesicle http://purl.obolibrary.org/obo/GO_0061200 GO:0036233 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036233 GO:0061201 biolink:CellularComponent clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle. go.json clathrin sculpted GABA transport vesicle lumen|clathrin sculpted gamma-aminobutyric acid transport vesicle lumen http://purl.obolibrary.org/obo/GO_0061201 GO:0036234 biolink:BiologicalProcess deglucuronidation The removal of glucuronic acid from a conjugated substrate. go.json http://purl.obolibrary.org/obo/GO_0036234 GO:0036235 biolink:BiologicalProcess acyl deglucuronidation The removal of glucuronic acid from an acyl-glucuronide. go.json http://purl.obolibrary.org/obo/GO_0036235 GO:0061202 biolink:CellularComponent clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle. go.json clathrin sculpted GABA transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane http://purl.obolibrary.org/obo/GO_0061202 GO:0036236 biolink:BiologicalProcess acyl glucuronidation The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside). go.json http://purl.obolibrary.org/obo/GO_0036236 GO:0061203 biolink:BiologicalProcess striated muscle paramyosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle. go.json http://purl.obolibrary.org/obo/GO_0061203 GO:0036237 biolink:MolecularActivity acyl-glucuronidase activity Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate. go.json acyl-glucuronide deglucuronidation activity http://purl.obolibrary.org/obo/GO_0036237 GO:0061204 biolink:BiologicalProcess paramyosin filament assembly or disassembly The formation or disassembly of a filament composed of paramyosin molecules. go.json http://purl.obolibrary.org/obo/GO_0061204 GO:0061205 biolink:BiologicalProcess paramesonephric duct development The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin. go.json Mullerian duct development http://purl.obolibrary.org/obo/GO_0061205 GO:0036238 biolink:MolecularActivity gallate dioxygenase activity Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate. EC:1.13.11.57|KEGG_REACTION:R09565|MetaCyc:GALLATE-DIOXYGENASE-RXN|RHEA:28927 go.json http://purl.obolibrary.org/obo/GO_0036238 GO:0061206 biolink:BiologicalProcess mesonephros morphogenesis The process in which the anatomical structures of the mesonephros are generated and organized. go.json Wolffian body morphogenesis http://purl.obolibrary.org/obo/GO_0061206 GO:0036239 biolink:MolecularActivity taxoid 7beta-hydroxylase activity Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O and 2alpha-hydroxytaxusin + [reduced NADPH-hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O. EC:1.14.14.182|KEGG_REACTION:R09868|MetaCyc:RXN-12885 go.json http://purl.obolibrary.org/obo/GO_0036239 GO:0061207 biolink:BiologicalProcess mesonephric juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061207 GO:0061208 biolink:BiologicalProcess cell differentiation involved in mesonephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061208 GO:0061209 biolink:BiologicalProcess cell proliferation involved in mesonephros development The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061209 GO:0051870 biolink:MolecularActivity methotrexate binding Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. go.json http://purl.obolibrary.org/obo/GO_0051870 GO:0051871 biolink:MolecularActivity dihydrofolic acid binding Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms. go.json DHF binding|dihydrofolate binding http://purl.obolibrary.org/obo/GO_0051871 GO:0036230 biolink:BiologicalProcess granulocyte activation The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0036230 GO:0036231 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036231 GO:0036232 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036232 GO:0051885 biolink:BiologicalProcess positive regulation of timing of anagen Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. go.json activation of anagen|positive regulation of anagen|stimulation of anagen|up regulation of anagen|up-regulation of anagen|upregulation of anagen http://purl.obolibrary.org/obo/GO_0051885 GO:0051886 biolink:BiologicalProcess negative regulation of timing of anagen Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. go.json down regulation of anagen|down-regulation of anagen|downregulation of anagen|inhibition of anagen|negative regulation of anagen http://purl.obolibrary.org/obo/GO_0051886 GO:0051883 biolink:BiologicalProcess obsolete killing of cells in other organism involved in symbiotic interaction OBSOLETE. Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. go.json killing of cells in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051883 GO:0051884 biolink:BiologicalProcess regulation of timing of anagen Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. go.json regulation of anagen http://purl.obolibrary.org/obo/GO_0051884 GO:0051889 biolink:BiologicalProcess negative regulation of timing of exogen Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. go.json down regulation of exogen|down-regulation of exogen|downregulation of exogen|inhibition of exogen|negative regulation of exogen http://purl.obolibrary.org/obo/GO_0051889 GO:0051887 biolink:BiologicalProcess regulation of timing of exogen Any process that modulates the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. go.json regulation of exogen http://purl.obolibrary.org/obo/GO_0051887 GO:0051888 biolink:BiologicalProcess positive regulation of timing of exogen Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. go.json activation of exogen|positive regulation of exogen|stimulation of exogen|up regulation of exogen|up-regulation of exogen|upregulation of exogen http://purl.obolibrary.org/obo/GO_0051888 GO:0036222 biolink:MolecularActivity XTP diphosphatase activity Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate. EC:3.6.1.66|KEGG_REACTION:R02720|MetaCyc:RXN0-1603|MetaCyc:RXN0-5074|RHEA:28610|Reactome:R-HSA-2509831 go.json XTP pyrophosphohydrolase activity|XTP/dITP diphosphatase|XTPase activity|hypoxanthine/xanthine dNTP pyrophosphatase http://purl.obolibrary.org/obo/GO_0036222 GO:0036223 biolink:BiologicalProcess cellular response to adenine starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine. go.json cellular response to adenine deprivation http://purl.obolibrary.org/obo/GO_0036223 GO:0036224 biolink:CellularComponent pairing center A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment. go.json homolog recognition region http://purl.obolibrary.org/obo/GO_0036224 GO:0036225 biolink:BiologicalProcess cellular response to vitamin B1 starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine). go.json cellular response to thiamin starvation|cellular response to vitamin B1 deprivation http://purl.obolibrary.org/obo/GO_0036225 GO:0036226 biolink:BiologicalProcess obsolete mitotic cell cycle arrest in response to glucose starvation OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose. go.json cell cycle arrest in response to glucose starvation True http://purl.obolibrary.org/obo/GO_0036226 GO:0036227 biolink:BiologicalProcess mitotic G2 cell cycle arrest in response to glucose starvation The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose. go.json http://purl.obolibrary.org/obo/GO_0036227 GO:0036228 biolink:BiologicalProcess protein localization to nuclear inner membrane A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane. go.json protein targeting to INM|protein targeting to nuclear inner membrane http://purl.obolibrary.org/obo/GO_0036228 GO:0036229 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036229 GO:0051881 biolink:BiologicalProcess regulation of mitochondrial membrane potential Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json http://purl.obolibrary.org/obo/GO_0051881 GO:0051882 biolink:BiologicalProcess mitochondrial depolarization The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level. go.json mitochondria depolarization|mitochondrial depolarisation|mitochondrial membrane depolarization|mitochondrion depolarization http://purl.obolibrary.org/obo/GO_0051882 GO:0036220 biolink:MolecularActivity ITP diphosphatase activity Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate. EC:3.6.1.66|KEGG_REACTION:R00720|MetaCyc:RXN0-6382|RHEA:29399|Reactome:R-HSA-2509827 go.json ITP pyrophosphatase activity|inosine-5'-triphosphate pyrophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0036220 GO:0036221 biolink:MolecularActivity UTP diphosphatase activity Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate. KEGG_REACTION:R00662|RHEA:29395 go.json uridine triphosphate pyrophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0036221 GO:0051880 biolink:MolecularActivity G-quadruplex DNA binding Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. go.json G quadruplex DNA binding|G quartet DNA binding|G quartet binding|G-DNA binding|G-quartet DNA binding|G-quartet binding|quadruplex DNA binding|tetraplex DNA binding http://purl.obolibrary.org/obo/GO_0051880 GO:0051896 biolink:BiologicalProcess regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. go.json regulation of AKT signaling cascade|regulation of AKT signalling cascade|regulation of PI3K-PKB/Akt pathway|regulation of PI3K/Akt signal transduction|regulation of PI3K/PKB signal transduction|regulation of PKB signaling cascade|regulation of PKB signalling cascade|regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction|regulation of protein kinase B signaling|regulation of protein kinase B signaling cascade|regulation of protein kinase B signalling cascade http://purl.obolibrary.org/obo/GO_0051896 GO:0051897 biolink:BiologicalProcess positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. go.json activation of protein kinase B signaling cascade|positive regulation of AKT signaling cascade|positive regulation of AKT signalling cascade|positive regulation of PI3K-PKB/Akt pathway|positive regulation of PI3K/Akt signal transduction|positive regulation of PI3K/PKB signal transduction|positive regulation of PKB signaling cascade|positive regulation of PKB signalling cascade|positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction|positive regulation of protein kinase B signaling|positive regulation of protein kinase B signaling cascade|positive regulation of protein kinase B signalling cascade|stimulation of protein kinase B signaling cascade|up regulation of protein kinase B signaling cascade|up-regulation of protein kinase B signaling cascade|upregulation of protein kinase B signaling cascade http://purl.obolibrary.org/obo/GO_0051897 GO:0051894 biolink:BiologicalProcess positive regulation of focal adhesion assembly Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. go.json activation of focal adhesion formation|stimulation of focal adhesion formation|up regulation of focal adhesion formation|up-regulation of focal adhesion formation|upregulation of focal adhesion formation http://purl.obolibrary.org/obo/GO_0051894 GO:0051895 biolink:BiologicalProcess negative regulation of focal adhesion assembly Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. go.json down regulation of focal adhesion formation|down-regulation of focal adhesion formation|downregulation of focal adhesion formation|inhibition of focal adhesion formation http://purl.obolibrary.org/obo/GO_0051895 GO:0051898 biolink:BiologicalProcess negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. go.json down regulation of protein kinase B signaling cascade|down-regulation of protein kinase B signaling cascade|downregulation of protein kinase B signaling cascade|inhibition of protein kinase B signaling cascade|negative regulation of AKT signaling cascade|negative regulation of AKT signalling cascade|negative regulation of PI3K-PKB/Akt pathway|negative regulation of PI3K/Akt signal transduction|negative regulation of PI3K/PKB signal transduction|negative regulation of PKB signaling cascade|negative regulation of PKB signalling cascade|negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction|negative regulation of protein kinase B signaling|negative regulation of protein kinase B signaling cascade|negative regulation of protein kinase B signalling cascade http://purl.obolibrary.org/obo/GO_0051898 GO:0051899 biolink:BiologicalProcess membrane depolarization The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. go.json http://purl.obolibrary.org/obo/GO_0051899 GO:0036219 biolink:MolecularActivity GTP diphosphatase activity Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate. KEGG_REACTION:R00426|RHEA:29391 go.json GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase|GTP diphosphohydrolase activity|GTP pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0036219 GO:0061220 biolink:BiologicalProcess mesonephric macula densa development The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus. go.json http://purl.obolibrary.org/obo/GO_0061220 GO:0061221 biolink:BiologicalProcess mesonephric mesenchyme morphogenesis The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061221 GO:0036211 biolink:BiologicalProcess protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). go.json cellular protein modification process|process resulting in protein modification|protein modification http://purl.obolibrary.org/obo/GO_0036211 goslim_candida|goslim_chembl|goslim_pir|goslim_plant|prokaryote_subset GO:0061222 biolink:BiologicalProcess mesonephric mesenchymal cell proliferation involved in mesonephros development The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population. go.json http://purl.obolibrary.org/obo/GO_0061222 GO:0036212 biolink:BiologicalProcess obsolete contractile ring maintenance OBSOLETE. The process in which the contractile ring is maintained, typically in response to an internal or external cue. go.json True http://purl.obolibrary.org/obo/GO_0036212 GO:0061223 biolink:BiologicalProcess mesonephric mesenchymal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061223 GO:0036213 biolink:BiologicalProcess contractile ring contraction The process of an actomyosin ring getting smaller in diameter. go.json contractile ring constriction http://purl.obolibrary.org/obo/GO_0036213 GO:0061224 biolink:BiologicalProcess mesonephric glomerulus development The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061224 GO:0061225 biolink:BiologicalProcess mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. go.json mesonephric Goormaghtigh proliferation|mesonephric lacis cell proliferation http://purl.obolibrary.org/obo/GO_0061225 GO:0036214 biolink:BiologicalProcess obsolete contractile ring localization OBSOLETE. The process in which a contractile ring is positioned or maintained in a specific location. go.json True http://purl.obolibrary.org/obo/GO_0036214 GO:0036215 biolink:BiologicalProcess response to stem cell factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus. go.json response to KIT ligand|response to SCF|response to hematopoietic growth factor KL|response to stem cell factor stimulus http://purl.obolibrary.org/obo/GO_0036215 GO:0061226 biolink:BiologicalProcess proximal/distal pattern formation involved in mesonephric nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end). go.json http://purl.obolibrary.org/obo/GO_0061226 GO:0036216 biolink:BiologicalProcess cellular response to stem cell factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus. go.json cellular response to KIT ligand|cellular response to KITLG|cellular response to SCF|cellular response to hematopoietic growth factor KL http://purl.obolibrary.org/obo/GO_0036216 GO:0061227 biolink:BiologicalProcess pattern specification involved in mesonephros development Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate. go.json mesonephros pattern formation|mesonephros pattern specification http://purl.obolibrary.org/obo/GO_0061227 GO:0036217 biolink:MolecularActivity dGTP diphosphatase activity Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate. KEGG_REACTION:R01855|RHEA:28362 go.json 2'-deoxyguanosine 5'-triphosphate diphosphohydrolase|dGTP pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0036217 GO:0061228 biolink:BiologicalProcess mesonephric nephron morphogenesis The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061228 GO:0036218 biolink:MolecularActivity dTTP diphosphatase activity Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate. MetaCyc:RXN0-5107|RHEA:28534 go.json dTTP pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0036218 GO:0061229 biolink:BiologicalProcess mesonephric juxtaglomerulus cell development The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061229 GO:0051892 biolink:BiologicalProcess negative regulation of cardioblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json down regulation of cardioblast differentiation|down-regulation of cardioblast differentiation|downregulation of cardioblast differentiation|inhibition of cardioblast differentiation http://purl.obolibrary.org/obo/GO_0051892 GO:0051893 biolink:BiologicalProcess regulation of focal adhesion assembly Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. go.json regulation of adhesion plaque assembly http://purl.obolibrary.org/obo/GO_0051893 GO:0051890 biolink:BiologicalProcess regulation of cardioblast differentiation Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0051890 GO:0036210 biolink:BiologicalProcess protein modification process in another organism The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). go.json protein modification in other organism|protein modification process in other organism http://purl.obolibrary.org/obo/GO_0036210 GO:0051891 biolink:BiologicalProcess positive regulation of cardioblast differentiation Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json activation of cardioblast differentiation|stimulation of cardioblast differentiation|up regulation of cardioblast differentiation|up-regulation of cardioblast differentiation|upregulation of cardioblast differentiation http://purl.obolibrary.org/obo/GO_0051891 GO:0036208 biolink:BiologicalProcess obsolete negative regulation of histone gene expression OBSOLETE. Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. go.json down-regulation of histone gene expression|downregulation of histone gene expression|inhibition of histone gene expression|negative regulation of expression of histone-encoding gene True http://purl.obolibrary.org/obo/GO_0036208 GO:0036209 biolink:MolecularActivity 9beta-pimara-7,15-diene oxidase activity Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.111|KEGG_REACTION:R09865|MetaCyc:RXN-15437|RHEA:31951 go.json 9-beta-stemod-13(17)-ene oxidase activity http://purl.obolibrary.org/obo/GO_0036209 GO:0061210 biolink:BiologicalProcess cell-cell signaling involved in mesonephros development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ. go.json cell-cell signalling involved in mesonephros development http://purl.obolibrary.org/obo/GO_0061210 GO:0061211 biolink:BiologicalProcess mesonephric collecting duct development The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. go.json http://purl.obolibrary.org/obo/GO_0061211 GO:0036200 biolink:MolecularActivity 3-ketosteroid 9-alpha-monooxygenase activity Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. EC:1.14.15.30|KEGG_REACTION:R09860|RHEA:32199 go.json 3-ketosteroid 9alpha-hydroxylase activity|KshAB activity http://purl.obolibrary.org/obo/GO_0036200 GO:0036201 biolink:MolecularActivity ent-isokaurene C2-hydroxylase activity Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+. EC:1.14.14.76|KEGG_REACTION:R09861|RHEA:56336 go.json http://purl.obolibrary.org/obo/GO_0036201 GO:0061212 biolink:BiologicalProcess mesonephric juxtaglomerular apparatus development The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate. go.json http://purl.obolibrary.org/obo/GO_0061212 GO:0036202 biolink:MolecularActivity ent-cassa-12,15-diene 11-hydroxylase activity Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O. EC:1.14.14.112|KEGG_REACTION:R09866|RHEA:31967 go.json ent-cassadiene C11alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0036202 GO:0061213 biolink:BiologicalProcess positive regulation of mesonephros development Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0061213 GO:0061214 biolink:BiologicalProcess mesonephric smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061214 GO:0036203 biolink:MolecularActivity taxoid 14-beta-hydroxylase activity Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O. EC:1.14.13.146|KEGG_REACTION:R09867|RHEA:31971 go.json http://purl.obolibrary.org/obo/GO_0036203 GO:0036204 biolink:MolecularActivity abieta-7,13-dien-18-ol hydroxylase activity Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O. EC:1.14.14.145|KEGG_REACTION:R06354|MetaCyc:RXN-12799|RHEA:26221 go.json http://purl.obolibrary.org/obo/GO_0036204 GO:0061215 biolink:BiologicalProcess mesonephric nephron development The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. go.json http://purl.obolibrary.org/obo/GO_0061215 GO:0061216 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in mesonephros development OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state. go.json True http://purl.obolibrary.org/obo/GO_0061216 GO:0036205 biolink:BiologicalProcess histone catabolic process The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells. go.json histone protein catabolic process http://purl.obolibrary.org/obo/GO_0036205 GO:0036206 biolink:BiologicalProcess obsolete regulation of histone gene expression OBSOLETE. Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. go.json regulation of expression of histone-encoding gene True http://purl.obolibrary.org/obo/GO_0036206 GO:0061217 biolink:BiologicalProcess regulation of mesonephros development Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0061217 GO:0061218 biolink:BiologicalProcess negative regulation of mesonephros development Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0061218 GO:0036207 biolink:BiologicalProcess obsolete positive regulation of histone gene expression OBSOLETE. Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. go.json activation of histone gene expression|positive regulation of expression of histone-encoding gene|up-regulation of histone gene expression|upregulation of histone gene expression True http://purl.obolibrary.org/obo/GO_0036207 GO:0061219 biolink:BiologicalProcess mesonephric mesenchyme development The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061219 GO:0061240 biolink:BiologicalProcess mesonephric nephron tubule morphogenesis The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061240 GO:0061241 biolink:BiologicalProcess mesonephric nephron epithelium development The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061241 GO:0061242 biolink:BiologicalProcess mesonephric nephron tubule development The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061242 GO:0061243 biolink:BiologicalProcess mesonephric renal vesicle morphogenesis The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0061243 GO:0061244 biolink:BiologicalProcess mesonephric S-shaped body morphogenesis The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061244 GO:0061245 biolink:BiologicalProcess establishment or maintenance of bipolar cell polarity Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. go.json http://purl.obolibrary.org/obo/GO_0061245 GO:0061246 biolink:BiologicalProcess establishment or maintenance of bipolar cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell. go.json http://purl.obolibrary.org/obo/GO_0061246 GO:0061247 biolink:BiologicalProcess mesonephric glomerular mesangium development The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus. go.json http://purl.obolibrary.org/obo/GO_0061247 GO:0061248 biolink:BiologicalProcess mesonephric glomerulus vasculature morphogenesis The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus. go.json http://purl.obolibrary.org/obo/GO_0061248 GO:0061249 biolink:BiologicalProcess mesonephric glomerular capillary formation The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0061249 GO:0061230 biolink:BiologicalProcess mesonephric juxtaglomerulus cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell. go.json http://purl.obolibrary.org/obo/GO_0061230 GO:0061231 biolink:BiologicalProcess mesonephric glomerulus vasculature development The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus. go.json http://purl.obolibrary.org/obo/GO_0061231 GO:0061232 biolink:BiologicalProcess mesonephric glomerular epithelium development The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061232 GO:0061233 biolink:BiologicalProcess mesonephric glomerular basement membrane development The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration. go.json http://purl.obolibrary.org/obo/GO_0061233 GO:0061234 biolink:BiologicalProcess mesonephric glomerulus morphogenesis The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061234 GO:0061235 biolink:BiologicalProcess mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0061235 GO:0061236 biolink:BiologicalProcess mesonephric comma-shaped body morphogenesis The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061236 GO:0061237 biolink:BiologicalProcess convergent extension involved in mesonephric nephron morphogenesis The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0061237 GO:0061238 biolink:BiologicalProcess establishment of planar polarity involved in mesonephric nephron morphogenesis Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros. go.json establishment of planar cell polarity involved in mesonephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0061238 GO:0061239 biolink:BiologicalProcess mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0061239 GO:0002885 biolink:BiologicalProcess positive regulation of hypersensitivity Any process that activates or increases the frequency, rate, or extent of hypersensitivity. go.json activation of hypersensitivity|stimulation of hypersensitivity|up regulation of hypersensitivity|up-regulation of hypersensitivity|upregulation of hypersensitivity http://purl.obolibrary.org/obo/GO_0002885 GO:0002886 biolink:BiologicalProcess regulation of myeloid leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. go.json http://purl.obolibrary.org/obo/GO_0002886 GO:0002887 biolink:BiologicalProcess negative regulation of myeloid leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. go.json down regulation of myeloid leukocyte mediated immunity|down-regulation of myeloid leukocyte mediated immunity|downregulation of myeloid leukocyte mediated immunity|inhibition of myeloid leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002887 GO:0002888 biolink:BiologicalProcess positive regulation of myeloid leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. go.json activation of myeloid leukocyte mediated immunity|stimulation of myeloid leukocyte mediated immunity|up regulation of myeloid leukocyte mediated immunity|up-regulation of myeloid leukocyte mediated immunity|upregulation of myeloid leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002888 GO:0002881 biolink:BiologicalProcess negative regulation of chronic inflammatory response to non-antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. go.json down regulation of chronic inflammatory response to non-antigenic stimulus|down-regulation of chronic inflammatory response to non-antigenic stimulus|downregulation of chronic inflammatory response to non-antigenic stimulus|inhibition of chronic inflammatory response to non-antigenic stimulus http://purl.obolibrary.org/obo/GO_0002881 GO:0002882 biolink:BiologicalProcess positive regulation of chronic inflammatory response to non-antigenic stimulus Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. go.json activation of chronic inflammatory response to non-antigenic stimulus|stimulation of chronic inflammatory response to non-antigenic stimulus|up regulation of chronic inflammatory response to non-antigenic stimulus|up-regulation of chronic inflammatory response to non-antigenic stimulus|upregulation of chronic inflammatory response to non-antigenic stimulus http://purl.obolibrary.org/obo/GO_0002882 GO:0002883 biolink:BiologicalProcess regulation of hypersensitivity Any process that modulates the frequency, rate, or extent of hypersensitivity. go.json http://purl.obolibrary.org/obo/GO_0002883 GO:0002884 biolink:BiologicalProcess negative regulation of hypersensitivity Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity. go.json down regulation of hypersensitivity|down-regulation of hypersensitivity|downregulation of hypersensitivity|inhibition of hypersensitivity http://purl.obolibrary.org/obo/GO_0002884 GO:0061260 biolink:BiologicalProcess mesonephric mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061260 GO:0061261 biolink:BiologicalProcess mesenchymal to epithelial transition involved in mesonephros morphogenesis A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros. go.json mesonephric mesenchyme to epithelial transition http://purl.obolibrary.org/obo/GO_0061261 GO:0002880 biolink:BiologicalProcess regulation of chronic inflammatory response to non-antigenic stimulus Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. go.json http://purl.obolibrary.org/obo/GO_0002880 GO:0061262 biolink:BiologicalProcess mesonephric renal vesicle formation The developmental process pertaining to the initial formation of the mesonephros. go.json mesonephros formation http://purl.obolibrary.org/obo/GO_0061262 GO:0061263 biolink:BiologicalProcess mesonephric glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061263 GO:0061264 biolink:BiologicalProcess mesonephric glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell. go.json http://purl.obolibrary.org/obo/GO_0061264 GO:0061265 biolink:BiologicalProcess mesonephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061265 GO:0061266 biolink:BiologicalProcess mesonephric interstitial fibroblast differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state. go.json mesonephros interstitial cell differentiation http://purl.obolibrary.org/obo/GO_0061266 GO:0061267 biolink:BiologicalProcess mesonephric interstitial fibroblast development The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure. go.json mesonephros interstitial cell development http://purl.obolibrary.org/obo/GO_0061267 GO:0061268 biolink:BiologicalProcess mesonephric interstitial fibroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast. go.json http://purl.obolibrary.org/obo/GO_0061268 GO:0061269 biolink:BiologicalProcess mesonephric glomerular mesangial cell proliferation involved in mesonephros development The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population. go.json http://purl.obolibrary.org/obo/GO_0061269 GO:0002889 biolink:BiologicalProcess regulation of immunoglobulin mediated immune response Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response. go.json http://purl.obolibrary.org/obo/GO_0002889 GO:0002896 biolink:BiologicalProcess negative regulation of central B cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction. go.json down regulation of central B cell tolerance induction|down-regulation of central B cell tolerance induction|downregulation of central B cell tolerance induction|inhibition of central B cell tolerance induction http://purl.obolibrary.org/obo/GO_0002896 GO:0002897 biolink:BiologicalProcess positive regulation of central B cell tolerance induction Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction. go.json activation of central B cell tolerance induction|stimulation of central B cell tolerance induction|up regulation of central B cell tolerance induction|up-regulation of central B cell tolerance induction|upregulation of central B cell tolerance induction http://purl.obolibrary.org/obo/GO_0002897 GO:0002898 biolink:BiologicalProcess regulation of central B cell deletion Any process that modulates the frequency, rate, or extent of central B cell deletion. go.json http://purl.obolibrary.org/obo/GO_0002898 GO:0002899 biolink:BiologicalProcess negative regulation of central B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion. go.json down regulation of central B cell deletion|down-regulation of central B cell deletion|downregulation of central B cell deletion|inhibition of central B cell deletion http://purl.obolibrary.org/obo/GO_0002899 GO:0002892 biolink:BiologicalProcess regulation of type II hypersensitivity Any process that modulates the frequency, rate, or extent of type II hypersensitivity. go.json http://purl.obolibrary.org/obo/GO_0002892 GO:0002893 biolink:BiologicalProcess negative regulation of type II hypersensitivity Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity. go.json down regulation of type II hypersensitivity|down-regulation of type II hypersensitivity|downregulation of type II hypersensitivity|inhibition of type II hypersensitivity http://purl.obolibrary.org/obo/GO_0002893 GO:0002894 biolink:BiologicalProcess positive regulation of type II hypersensitivity Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity. go.json activation of type II hypersensitivity|stimulation of type II hypersensitivity|up regulation of type II hypersensitivity|up-regulation of type II hypersensitivity|upregulation of type II hypersensitivity http://purl.obolibrary.org/obo/GO_0002894 GO:0002895 biolink:BiologicalProcess regulation of central B cell tolerance induction Any process that modulates the frequency, rate, or extent of central B cell tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0002895 GO:0002890 biolink:BiologicalProcess negative regulation of immunoglobulin mediated immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response. go.json down regulation of immunoglobulin mediated immune response|down-regulation of immunoglobulin mediated immune response|downregulation of immunoglobulin mediated immune response|inhibition of immunoglobulin mediated immune response http://purl.obolibrary.org/obo/GO_0002890 GO:0002891 biolink:BiologicalProcess positive regulation of immunoglobulin mediated immune response Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. go.json activation of immunoglobulin mediated immune response|stimulation of immunoglobulin mediated immune response|up regulation of immunoglobulin mediated immune response|up-regulation of immunoglobulin mediated immune response|upregulation of immunoglobulin mediated immune response http://purl.obolibrary.org/obo/GO_0002891 GO:0061250 biolink:BiologicalProcess mesonephric glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0061250 GO:0061251 biolink:BiologicalProcess mesonephric glomerular epithelial cell development The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0061251 GO:0061252 biolink:BiologicalProcess mesonephric glomerular epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0061252 GO:0061253 biolink:BiologicalProcess mesonephric glomerular parietal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. go.json http://purl.obolibrary.org/obo/GO_0061253 GO:0061254 biolink:BiologicalProcess mesonephric glomerular parietal epithelial cell development The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. go.json http://purl.obolibrary.org/obo/GO_0061254 GO:0061255 biolink:BiologicalProcess mesonephric glomerular parietal epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. go.json http://purl.obolibrary.org/obo/GO_0061255 GO:0061256 biolink:BiologicalProcess mesonephric podocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. go.json mesonephric glomerular visceral epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0061256 GO:0061257 biolink:BiologicalProcess mesonephric podocyte development The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. go.json mesonephric glomerular visceral epithelial cell development http://purl.obolibrary.org/obo/GO_0061257 GO:0061258 biolink:BiologicalProcess mesonephric podocyte cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. go.json mesonephric glomerular visceral epithelial cell fate commitment http://purl.obolibrary.org/obo/GO_0061258 GO:0061259 biolink:BiologicalProcess mesonephric glomerular mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061259 GO:0051801 biolink:BiologicalProcess obsolete cytolysis in other organism involved in symbiotic interaction OBSOLETE. The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction. go.json cytolysis of cells in other organism during symbiotic interaction|cytolysis of cells in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051801 GO:0051802 biolink:BiologicalProcess obsolete regulation of cytolysis in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. go.json regulation of cytolysis of cells in other organism during symbiotic interaction|regulation of cytolysis of cells in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051802 GO:0051800 biolink:MolecularActivity phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. Reactome:R-HSA-1676149|Reactome:R-HSA-1676204 go.json PTEN activity http://purl.obolibrary.org/obo/GO_0051800 GO:0051805 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051805 GO:0051806 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051806 GO:0051803 biolink:BiologicalProcess obsolete negative regulation of cytolysis in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. go.json down regulation of cytolysis of cells in other organism during symbiotic interaction|down-regulation of cytolysis of cells in other organism during symbiotic interaction|downregulation of cytolysis of cells in other organism during symbiotic interaction|inhibition of cytolysis of cells in other organism during symbiotic interaction|negative regulation of cytolysis of cells in other organism during symbiotic interaction|negative regulation of cytolysis of cells in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051803 GO:0051804 biolink:BiologicalProcess obsolete positive regulation of cytolysis in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. go.json activation of cytolysis of cells in other organism during symbiotic interaction|positive regulation of cytolysis of cells in other organism during symbiotic interaction|positive regulation of cytolysis of cells in other organism involved in symbiotic interaction|stimulation of cytolysis of cells in other organism during symbiotic interaction|up regulation of cytolysis of cells in other organism during symbiotic interaction|up-regulation of cytolysis of cells in other organism during symbiotic interaction|upregulation of cytolysis of cells in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051804 GO:0051809 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051809 GO:0051807 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051807 GO:0051808 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051808 GO:0051812 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051812 GO:0051813 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051813 GO:0051810 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051810 GO:0051811 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051811 GO:0051816 biolink:BiologicalProcess obsolete acquisition of nutrients from other organism during symbiotic interaction OBSOLETE. The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0051816 GO:0051817 biolink:BiologicalProcess obsolete modulation of process of other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction. go.json modification of morphology or physiology of other organism during symbiotic interaction|modification of morphology or physiology of other organism involved in symbiotic interaction|modulation of biological process of other organism involved in symbiotic interaction|modulation of morphology or physiology of other organism during symbiotic interaction|regulation of morphology of other organism during symbiotic interaction|regulation of morphology or physiology of other organism during symbiotic interaction|regulation of physiological process in other organism during symbiotic interaction|regulation of physiology of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051817 GO:0051814 biolink:BiologicalProcess obsolete movement in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction. go.json movement in other organism during symbiotic interaction|movement within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051814 GO:0051815 biolink:BiologicalProcess obsolete migration in other organism involved in symbiotic interaction OBSOLETE. The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction. go.json migration in other organism during symbiotic interaction|migration within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051815 GO:0051818 biolink:BiologicalProcess obsolete disruption of cells of other organism involved in symbiotic interaction OBSOLETE. A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. go.json disruption of cells of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051818 GO:0051819 biolink:BiologicalProcess induction by symbiont of tumor or growth in host The process in which a symbiont causes the formation of a mass of cells in a host organism. While these growths are often called nodules, they are not formed as nitrogen-fixing structures, but rather to provide an environment for the symbiont to grow. In this sense they are parasitic structures rather than mutualistic. go.json induction by symbiont in host of tumor, nodule, or growth|induction by symbiont in host of tumor, nodule, or growth containing transformed cells|induction by symbiont of nodulation, tumor or growth in host|induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction|induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction|induction of tumor, nodule, or growth in other organism during symbiotic interaction|induction of tumor, nodule, or growth in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0051819 GO:0036299 biolink:BiologicalProcess non-recombinational interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination. go.json recombination-independent ICL repair|recombination-independent interstrand cross-link repair http://purl.obolibrary.org/obo/GO_0036299 GO:0036291 biolink:BiologicalProcess protein cis-autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues. go.json cis-autophosphorylation http://purl.obolibrary.org/obo/GO_0036291 gocheck_do_not_annotate GO:0036292 biolink:BiologicalProcess DNA rewinding The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA. go.json DNA annealing|RPA-dependent DNA rewinding|single-stranded DNA bubble rewinding http://purl.obolibrary.org/obo/GO_0036292 GO:0036293 biolink:BiologicalProcess response to decreased oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. go.json response to lowered oxygen levels http://purl.obolibrary.org/obo/GO_0036293 GO:0036294 biolink:BiologicalProcess cellular response to decreased oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. go.json cellular response to lowered oxygen levels http://purl.obolibrary.org/obo/GO_0036294 GO:0036295 biolink:BiologicalProcess cellular response to increased oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. go.json cellular response to raised oxygen levels http://purl.obolibrary.org/obo/GO_0036295 GO:0036296 biolink:BiologicalProcess response to increased oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. go.json response to raised oxygen levels http://purl.obolibrary.org/obo/GO_0036296 GO:0036297 biolink:BiologicalProcess interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. go.json ICL repair http://purl.obolibrary.org/obo/GO_0036297 GO:0036298 biolink:BiologicalProcess recombinational interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. go.json recombination-dependent interstrand cross-link repair http://purl.obolibrary.org/obo/GO_0036298 GO:0051820 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051820 GO:0051823 biolink:BiologicalProcess regulation of synapse structural plasticity Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane. go.json regulation of synaptic structural plasticity http://purl.obolibrary.org/obo/GO_0051823 GO:0051824 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051824 GO:0051821 biolink:BiologicalProcess obsolete dissemination or transmission of organism from other organism involved in symbiotic interaction OBSOLETE. The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism. go.json dissemination or transmission of organism from other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051821 GO:0036290 biolink:BiologicalProcess protein trans-autophosphorylation The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer. go.json trans-autophosphorylation http://purl.obolibrary.org/obo/GO_0036290 gocheck_do_not_annotate GO:0051822 biolink:BiologicalProcess obsolete dissemination or transmission of organism from other organism by vector involved in symbiotic interaction OBSOLETE. The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal. go.json dissemination or transmission of organism from other organism by vector during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051822 GO:0051827 biolink:BiologicalProcess obsolete growth or development on or near surface of other organism during symbiotic interaction OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction. go.json growth or development on or near surface of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0051827 GO:0051828 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051828 GO:0051825 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051825 GO:0051826 biolink:BiologicalProcess negative regulation of synapse structural plasticity Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity. go.json down regulation of synapse structural plasticity|down-regulation of synapse structural plasticity|downregulation of synapse structural plasticity|inhibition of synapse structural plasticity http://purl.obolibrary.org/obo/GO_0051826 GO:0120006 biolink:BiologicalProcess regulation of glutamatergic neuron differentiation Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_0120006 GO:0120007 biolink:BiologicalProcess negative regulation of glutamatergic neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_0120007 GO:0120008 biolink:BiologicalProcess positive regulation of glutamatergic neuron differentiation Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_0120008 GO:0051829 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051829 GO:0120009 biolink:BiologicalProcess intermembrane lipid transfer The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). go.json http://purl.obolibrary.org/obo/GO_0120009 GO:0036288 biolink:BiologicalProcess response to ximelagatran Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus. go.json http://purl.obolibrary.org/obo/GO_0036288 gocheck_do_not_manually_annotate GO:0120002 biolink:CellularComponent fusiform vesicle A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder. go.json http://purl.obolibrary.org/obo/GO_0120002 GO:0120003 biolink:CellularComponent hinge region between urothelial plaques of apical plasma membrane A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0120003 GO:0036289 biolink:BiologicalProcess peptidyl-serine autophosphorylation The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. go.json serine autophosphorylation http://purl.obolibrary.org/obo/GO_0036289 gocheck_do_not_annotate GO:0120001 biolink:CellularComponent apical plasma membrane urothelial plaque A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array. go.json AUM|asymmetric unit membrane http://purl.obolibrary.org/obo/GO_0120001 GO:0036280 biolink:BiologicalProcess cellular response to L-canavanine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. go.json http://purl.obolibrary.org/obo/GO_0036280 GO:0036281 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036281 GO:0036282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036282 GO:0036283 biolink:BiologicalProcess obsolete positive regulation of transcription factor import into nucleus in response to oxidative stress OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress. go.json positive regulation of transcription factor import into nucleus in response to hydrogen peroxide True http://purl.obolibrary.org/obo/GO_0036283 GO:0036284 biolink:CellularComponent tubulobulbar complex Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes. go.json TBC http://purl.obolibrary.org/obo/GO_0036284 GO:0036285 biolink:BiologicalProcess SAGA complex assembly The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof. go.json SAGA complex formation http://purl.obolibrary.org/obo/GO_0036285 GO:0036286 biolink:CellularComponent eisosome filament A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1. go.json linear eisosome http://purl.obolibrary.org/obo/GO_0036286 GO:0036287 biolink:BiologicalProcess response to iloperidone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus. go.json http://purl.obolibrary.org/obo/GO_0036287 gocheck_do_not_manually_annotate GO:0051830 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051830 GO:0051831 biolink:BiologicalProcess obsolete growth or development in other organism during symbiotic interaction OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism. go.json growth or development in other organism during symbiotic interaction|growth or development within other organism during symbiotic interaction|invasive growth True http://purl.obolibrary.org/obo/GO_0051831 GO:0051834 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051834 GO:0051835 biolink:BiologicalProcess positive regulation of synapse structural plasticity Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity. go.json activation of synapse structural plasticity|stimulation of synapse structural plasticity|up regulation of synapse structural plasticity|up-regulation of synapse structural plasticity|upregulation of synapse structural plasticity http://purl.obolibrary.org/obo/GO_0051835 GO:0051832 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051832 GO:0051833 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051833 GO:0051838 biolink:BiologicalProcess cytolysis by host of symbiont cells The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0051838 GO:0051839 biolink:BiologicalProcess obsolete regulation by host of cytolysis of symbiont cells OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0051839 GO:0051836 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051836 GO:0051837 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051837 GO:0036277 biolink:BiologicalProcess response to anticonvulsant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity. go.json http://purl.obolibrary.org/obo/GO_0036277 gocheck_do_not_manually_annotate GO:0036278 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen. go.json True http://purl.obolibrary.org/obo/GO_0036278 GO:0036279 biolink:BiologicalProcess positive regulation of protein export from nucleus in response to glucose starvation Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose. go.json http://purl.obolibrary.org/obo/GO_0036279 GO:0036270 biolink:BiologicalProcess response to diuretic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function. go.json http://purl.obolibrary.org/obo/GO_0036270 gocheck_do_not_manually_annotate GO:0036271 biolink:BiologicalProcess response to methylphenidate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus. go.json response to MPD|response to MPH|response to ritalin http://purl.obolibrary.org/obo/GO_0036271 gocheck_do_not_manually_annotate GO:0036272 biolink:BiologicalProcess response to gemcitabine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas. go.json response to 2',2'-difluorodeoxycytidine|response to 2'-deoxy-2',2'-difluorocytidine http://purl.obolibrary.org/obo/GO_0036272 gocheck_do_not_manually_annotate GO:0036273 biolink:BiologicalProcess response to statin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties. go.json response to HMG-CoA reductase inhibitor|response to hydroxymethylglutaryl-CoA reductase inhibitor http://purl.obolibrary.org/obo/GO_0036273 gocheck_do_not_manually_annotate GO:0036274 biolink:BiologicalProcess response to lapatinib Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus. go.json http://purl.obolibrary.org/obo/GO_0036274 gocheck_do_not_manually_annotate GO:0036275 biolink:BiologicalProcess response to 5-fluorouracil Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus. go.json response to 5-fluoropyrimidine-2,4(1H,3H)-dione|response to fluorouracil http://purl.obolibrary.org/obo/GO_0036275 gocheck_do_not_manually_annotate GO:0036276 biolink:BiologicalProcess response to antidepressant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug. go.json http://purl.obolibrary.org/obo/GO_0036276 gocheck_do_not_manually_annotate GO:0051841 biolink:BiologicalProcess obsolete positive regulation by host of cytolysis of symbiont cells OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of cytolysis of symbiont cells|stimulation by host of cytolysis of symbiont cells|up regulation by host of cytolysis of symbiont cells|up-regulation by host of cytolysis of symbiont cells|upregulation by host of cytolysis of symbiont cells True http://purl.obolibrary.org/obo/GO_0051841 GO:0051842 biolink:BiologicalProcess obsolete evasion or tolerance of symbiont immune response OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json evasion or tolerance of symbiont immune response|immune evasion True http://purl.obolibrary.org/obo/GO_0051842 GO:0051840 biolink:BiologicalProcess obsolete negative regulation by host of cytolysis of symbiont cells OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json down regulation by host of cytolysis of symbiont cells|down-regulation by host of cytolysis of symbiont cells|downregulation by host of cytolysis of symbiont cells|inhibition by host of cytolysis of symbiont cells True http://purl.obolibrary.org/obo/GO_0051840 GO:0051845 biolink:BiologicalProcess obsolete passive evasion of symbiont immune response OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json passive evasion of symbiont immune response|passive immune evasion True http://purl.obolibrary.org/obo/GO_0051845 GO:0051846 biolink:BiologicalProcess obsolete active evasion of symbiont immune response OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json active evasion of symbiont immune response|active immune evasion True http://purl.obolibrary.org/obo/GO_0051846 GO:0051843 biolink:BiologicalProcess obsolete evasion or tolerance of symbiont defense response OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json evasion of symbiont defence response|evasion or tolerance of symbiont defense response True http://purl.obolibrary.org/obo/GO_0051843 GO:0051844 biolink:BiologicalProcess translocation of peptides or proteins into symbiont The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json transport of peptides or proteins into symbiont http://purl.obolibrary.org/obo/GO_0051844 GO:0051849 biolink:BiologicalProcess obsolete active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation|active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway|active immune evasion via modulation of symbiont antigen processing and presentation|active immune evasion via modulation of symbiont antigen processing/presentation|active immune evasion via regulation of symbiont antigen processing or presentation True http://purl.obolibrary.org/obo/GO_0051849 GO:0051847 biolink:BiologicalProcess obsolete active evasion of symbiont immune response via regulation of symbiont complement system OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json active evasion of symbiont immune response via regulation of symbiont complement system|active immune evasion via modulation of symbiont complement system|active immune evasion via regulation of symbiont complement system True http://purl.obolibrary.org/obo/GO_0051847 GO:0051848 biolink:BiologicalProcess obsolete active evasion of symbiont immune response via regulation of symbiont cytokine network OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json active evasion of symbiont immune response via regulation of symbiont cytokine network|active immune evasion via modulation of symbiont cytokine network|active immune evasion via regulation of symbiont cytokine network True http://purl.obolibrary.org/obo/GO_0051848 GO:0036266 biolink:CellularComponent Cdc48p-Npl4p-Vms1p AAA ATPase complex A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p. go.json Cdc48p-Npl4p-Vms1p complex|Vms1-Cdc48-Npl4 complex|Vms1p-Cdc48p-Npl4p complex http://purl.obolibrary.org/obo/GO_0036266 GO:0036267 biolink:BiologicalProcess invasive filamentous growth The growth of colonies in filamentous chains of cells into a substrate. go.json invasive growth http://purl.obolibrary.org/obo/GO_0036267 GO:0036268 biolink:BiologicalProcess swimming Self-propelled movement of an organism from one location to another through water, often by means of active fin movement. go.json http://purl.obolibrary.org/obo/GO_0036268 GO:0036269 biolink:BiologicalProcess swimming behavior The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water. go.json swimming behaviour http://purl.obolibrary.org/obo/GO_0036269 GO:0036260 biolink:BiologicalProcess RNA capping The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts. go.json http://purl.obolibrary.org/obo/GO_0036260 GO:0036261 biolink:BiologicalProcess 7-methylguanosine cap hypermethylation Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation. go.json 2,2,7-trimethylguanosine cap formation|TMG cap formation|conversion of m(7)G to m(3)G|hypermethylation of snRNA cap|hypermethylation of snoRNA cap|m(7)G cap hypermethylation|snRNA capping|snoRNA capping http://purl.obolibrary.org/obo/GO_0036261 GO:0036262 biolink:BiologicalProcess granulysin production The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0036262 gocheck_do_not_annotate GO:0036263 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036263 GO:0036264 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036264 GO:0036265 biolink:BiologicalProcess RNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0036265 GO:0051852 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051852 GO:0051853 biolink:BiologicalProcess obsolete induction in symbiont of tumor, nodule, or growth OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction in symbiont of tumor, nodule, or growth True http://purl.obolibrary.org/obo/GO_0051853 GO:0051850 biolink:BiologicalProcess acquisition of nutrients from symbiont The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0051850 GO:0051851 biolink:BiologicalProcess modulation by host of symbiont process The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modification by host of symbiont morphology or physiology http://purl.obolibrary.org/obo/GO_0051851 GO:0051856 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051856 GO:0051857 biolink:BiologicalProcess obsolete growth or development of organism on or near symbiont surface OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json growth or development of organism during interaction with symbiont|growth or development of organism on or near symbiont surface True http://purl.obolibrary.org/obo/GO_0051857 GO:0051854 biolink:BiologicalProcess obsolete induction in symbiont of tumor, nodule, or growth containing transformed cells OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction in symbiont of tumor, nodule, or growth containing transformed cells True http://purl.obolibrary.org/obo/GO_0051854 GO:0051855 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051855 GO:0051858 biolink:BiologicalProcess obsolete avoidance of symbiont defenses OBSOLETE. Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0051858 GO:0051859 biolink:BiologicalProcess obsolete suppression of symbiont defenses OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0051859 GO:0036255 biolink:BiologicalProcess response to methylamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus. go.json http://purl.obolibrary.org/obo/GO_0036255 GO:0036256 biolink:BiologicalProcess cellular response to methylamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus. go.json http://purl.obolibrary.org/obo/GO_0036256 GO:0036257 biolink:BiologicalProcess multivesicular body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. go.json MVB organization http://purl.obolibrary.org/obo/GO_0036257 GO:0036258 biolink:BiologicalProcess multivesicular body assembly The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. go.json MVB biogenesis|MVB formation|multivesicular body biogenesis http://purl.obolibrary.org/obo/GO_0036258 GO:0036259 biolink:BiologicalProcess aerobic raffinose catabolic process The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen. go.json aerobic raffinose breakdown|aerobic raffinose catabolism|aerobic raffinose degradation http://purl.obolibrary.org/obo/GO_0036259 GO:0036250 biolink:BiologicalProcess peroxisome transport along microtubule The directed movement of a peroxisome along a microtubule, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_0036250 GO:0036251 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to salt stress OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json True http://purl.obolibrary.org/obo/GO_0036251 GO:0036252 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to menadione OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position. go.json positive regulation of transcription from RNA polymerase II promoter in response to menadione stress True http://purl.obolibrary.org/obo/GO_0036252 GO:0036253 biolink:BiologicalProcess obsolete response to amiloride OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus. go.json True http://purl.obolibrary.org/obo/GO_0036253 GO:0036254 biolink:BiologicalProcess obsolete cellular response to amiloride OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus. go.json True http://purl.obolibrary.org/obo/GO_0036254 GO:0051863 biolink:BiologicalProcess obsolete translocation of DNA into symbiont OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json translocation of DNA into symbiont True http://purl.obolibrary.org/obo/GO_0051863 GO:0051864 biolink:MolecularActivity histone H3K36 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. go.json [histone-H3]-lysine-36 demethylase activity|histone H3-K36 demethylase activity|histone H3-lysine-36 demethylase activity|histone H3-methyl-lysine-36 demethylase activity|histone demethylase activity (H3-K36 specific)|histone-lysine (H3-K36) demethylase activity|histone-lysine demethylase activity (H3-K36 specific)|histone-lysine(H3-K36) demethylase activity http://purl.obolibrary.org/obo/GO_0051864 GO:0051861 biolink:MolecularActivity glycolipid binding Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. go.json http://purl.obolibrary.org/obo/GO_0051861 GO:0051862 biolink:BiologicalProcess translocation of molecules into symbiont The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json transport of molecules into symbiont http://purl.obolibrary.org/obo/GO_0051862 GO:0051867 biolink:BiologicalProcess general adaptation syndrome, behavioral process The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus. go.json behavioral process during general adaptation syndrome|behavioral response during general adaptation syndrome|behavioural process during general adaptation syndrome|behavioural response during general adaptation syndrome|general adaptation syndrome, behavioral response|general adaptation syndrome, behavioural process|general adaptation syndrome, behavioural response http://purl.obolibrary.org/obo/GO_0051867 GO:0051868 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051868 GO:0051865 biolink:BiologicalProcess protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. go.json protein auto-ubiquitination|protein auto-ubiquitinylation|protein autoubiquitinylation|protein self-ubiquitination|protein self-ubiquitinylation http://purl.obolibrary.org/obo/GO_0051865 GO:0051866 biolink:BiologicalProcess general adaptation syndrome General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses. go.json general adaptation syndrome, physiological process|general adaptation syndrome, physiological response|physiological process during general adaptation syndrome|physiological response during general adaptation syndrome http://purl.obolibrary.org/obo/GO_0051866 GO:0051869 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051869 GO:0036244 biolink:BiologicalProcess cellular response to neutral pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. go.json http://purl.obolibrary.org/obo/GO_0036244 GO:0036245 biolink:BiologicalProcess cellular response to menadione Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position. go.json cellular response to vitamin K3 http://purl.obolibrary.org/obo/GO_0036245 GO:0036246 biolink:BiologicalProcess phytochelatin 2 import into vacuole The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond. go.json PC2 import into vacuole http://purl.obolibrary.org/obo/GO_0036246 GO:0036247 biolink:BiologicalProcess phytochelatin 3 import into vacuole The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond. go.json PC3 import into vacuole http://purl.obolibrary.org/obo/GO_0036247 GO:0036248 biolink:BiologicalProcess phytochelatin 4 import into vacuole The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond. go.json PC4 import into vacuole http://purl.obolibrary.org/obo/GO_0036248 GO:0036249 biolink:BiologicalProcess cadmium ion import into vacuole The directed movement of cadmium ions into the vacuole. go.json vacuolar cadmium import http://purl.obolibrary.org/obo/GO_0036249 GO:0036240 biolink:CellularComponent septal periplasm The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi. go.json cell wall-enclosed septal periplasm http://purl.obolibrary.org/obo/GO_0036240 GO:0036241 biolink:BiologicalProcess glutamate catabolic process to 4-hydroxybutyrate The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate. go.json glutamate degradation to 4-hydroxybutyrate http://purl.obolibrary.org/obo/GO_0036241 GO:0051860 biolink:BiologicalProcess obsolete evasion or tolerance of symbiont defenses OBSOLETE. The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0051860 GO:0036242 biolink:BiologicalProcess glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase. go.json http://purl.obolibrary.org/obo/GO_0036242 GO:0036243 biolink:MolecularActivity succinate-semialdehyde dehydrogenase (NADP+) activity Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+. EC:1.2.1.79|MetaCyc:SUCCSEMIALDDEHYDROG-RXN|RHEA:13213 go.json NADP-dependent succinate-semialdehyde dehydrogenase activity|succinate semialdehyde:NADP+ oxidoreductase activity|succinic semialdehyde dehydrogenase (NADP+) activity|succinyl semialdehyde dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0036243 GO:0120299 biolink:MolecularActivity peptide histaminyltransferase activity Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]. RHEA:66564 go.json http://purl.obolibrary.org/obo/GO_0120299 GO:0120295 biolink:MolecularActivity histone serotonyltransferase activity Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+). go.json http://purl.obolibrary.org/obo/GO_0120295 GO:0120296 biolink:MolecularActivity peptide dopaminyltransferase activity Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+). RHEA:66556 go.json http://purl.obolibrary.org/obo/GO_0120296 GO:0120297 biolink:MolecularActivity histone dopaminyltransferase activity Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+). go.json http://purl.obolibrary.org/obo/GO_0120297 GO:0120298 biolink:MolecularActivity peptide noradrenalinyltransferase activity Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+). RHEA:66560 go.json http://purl.obolibrary.org/obo/GO_0120298 GO:0120291 biolink:BiologicalProcess negative regulation of mitotic recombination-dependent replication fork processing Any process that inhibits or decreases the rate of mitotic recombination-dependent replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching. go.json maintenance of template fidelity during replication fork processing|negative regulation of mitotic recombination involved in replication fork processing|negative regulation of template switch recombination involved in replication fork processing|suppression of template switching during replication fork processing http://purl.obolibrary.org/obo/GO_0120291 GO:0120292 biolink:BiologicalProcess positive regulation of mitotic recombination-dependent replication fork processing Any process that activates or increases the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. Proteins involved in homologous recombination are required for replication restart. go.json positive regulation of homologous recombination dependent replication fork recovery|positive regulation of mitotic recombination involved in replication fork processing|positive regulation of recombination-dependent DNA replication http://purl.obolibrary.org/obo/GO_0120292 GO:0120293 biolink:CellularComponent dynein axonemal particle An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. go.json DynAP http://purl.obolibrary.org/obo/GO_0120293 GO:0120294 biolink:MolecularActivity peptide serotonyltransferase activity Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+). RHEA:66552 go.json http://purl.obolibrary.org/obo/GO_0120294 GO:0120290 biolink:BiologicalProcess stalled replication fork localization to nuclear periphery A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication. go.json stalled replication fork localization to nuclear periphery involved in replication fork processing http://purl.obolibrary.org/obo/GO_0120290 GO:0120259 biolink:CellularComponent 7SK snRNP A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. go.json snRNP 7SK http://purl.obolibrary.org/obo/GO_0120259 GO:0120255 biolink:BiologicalProcess olefinic compound biosynthetic process The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). go.json alkene substituted compound anabolic process|alkene substituted compound anabolism|alkene substituted compound biosynthesis|alkene substituted compound biosynthetic process|alkene substituted compound synthesis http://purl.obolibrary.org/obo/GO_0120255 GO:0120256 biolink:BiologicalProcess olefinic compound catabolic process The chemical reactions and pathways resulting in the breakdown of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). go.json alkene substituted compound breakdown|alkene substituted compound catabolic process|alkene substituted compound catabolism|alkene substituted compound degradation http://purl.obolibrary.org/obo/GO_0120256 GO:0120257 biolink:BiologicalProcess peptidyl-threonine acetylation The acetylation of peptidyl-threonine. go.json http://purl.obolibrary.org/obo/GO_0120257 gocheck_do_not_annotate GO:0120258 biolink:BiologicalProcess peptidyl-threonine O-acetylation The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine. RESID:AA0364 go.json http://purl.obolibrary.org/obo/GO_0120258 gocheck_do_not_annotate GO:0120251 biolink:BiologicalProcess hydrocarbon biosynthetic process The chemical reactions and pathways resulting in the formation of a hydrocarbon, a compound consisting of carbon and hydrogen only. go.json hydrocarbon anabolism|hydrocarbon biosynthesis|hydrocarbon formation|hydrocarbon synthesis http://purl.obolibrary.org/obo/GO_0120251 GO:0120252 biolink:BiologicalProcess hydrocarbon metabolic process The chemical reactions and pathways involving a hydrocarbon, a compound consisting of carbon and hydrogen only. go.json hydrocarbon metabolism http://purl.obolibrary.org/obo/GO_0120252 GO:0120253 biolink:BiologicalProcess hydrocarbon catabolic process The chemical reactions and pathways resulting in the breakdown of a hydrocarbon, a compound consisting of carbon and hydrogen only. go.json hydrocarbon breakdown|hydrocarbon catabolism|hydrocarbon degradation http://purl.obolibrary.org/obo/GO_0120253 GO:0120254 biolink:BiologicalProcess olefinic compound metabolic process The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). go.json alkene substituted compound metabolic process|alkene substituted compound metabolism http://purl.obolibrary.org/obo/GO_0120254 GO:0120250 biolink:MolecularActivity fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. RHEA:39023 go.json http://purl.obolibrary.org/obo/GO_0120250 GO:0120266 biolink:BiologicalProcess positive regulation of chromosome attachment to the nuclear envelope Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope. go.json activation of chromosome attachment to the nuclear envelope|stimulation of chromosome attachment to the nuclear envelope|up regulation of chromosome attachment to the nuclear envelope|up-regulation of chromosome attachment to the nuclear envelope|upregulation of chromosome attachment to the nuclear envelope http://purl.obolibrary.org/obo/GO_0120266 GO:0120267 biolink:CellularComponent pellicular membrane The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles. go.json pellicle membrane|pellicular plasma membrane http://purl.obolibrary.org/obo/GO_0120267 GO:0120268 biolink:BiologicalProcess paraflagellar rod assembly The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. go.json PFR assembly|paraflagellar rod biogenesis|paraflagellar rod formation http://purl.obolibrary.org/obo/GO_0120268 GO:0120269 biolink:CellularComponent ciliary centrin arm A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules. go.json http://purl.obolibrary.org/obo/GO_0120269 GO:0120262 biolink:BiologicalProcess negative regulation of heterochromatin organization Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization. go.json down regulation of heterochromatin organization|down-regulation of heterochromatin organization|downregulation of heterochromatin organization|inhibition of heterochromatin organization http://purl.obolibrary.org/obo/GO_0120262 GO:0120263 biolink:BiologicalProcess positive regulation of heterochromatin organization Any process that activates or increases the frequency, rate or extent of heterochromatin organization. go.json activation of heterochromatin organization|stimulation of heterochromatin organization|up regulation of heterochromatin organization|up-regulation of heterochromatin organization|upregulation of heterochromatin organization http://purl.obolibrary.org/obo/GO_0120263 GO:0120264 biolink:BiologicalProcess regulation of chromosome attachment to the nuclear envelope Any process that modulates the frequency, rate, extent or location of chromosome attachment to the nuclear envelope. go.json http://purl.obolibrary.org/obo/GO_0120264 GO:0120265 biolink:BiologicalProcess negative regulation of chromosome attachment to the nuclear envelope Any process that stops, prevents, or reduces the frequency, rate or extent of the chromosome attachment to the nuclear envelope. go.json down regulation of chromosome attachment to the nuclear envelope|down-regulation of chromosome attachment to the nuclear envelope|downregulation of chromosome attachment to the nuclear envelope|inhibition of chromosome attachment to the nuclear envelope http://purl.obolibrary.org/obo/GO_0120265 GO:0120260 biolink:CellularComponent ciliary microtubule quartet A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape. go.json ciliary MtQ http://purl.obolibrary.org/obo/GO_0120260 GO:0120261 biolink:BiologicalProcess regulation of heterochromatin organization Any process that modulates the frequency, rate, extent or location of heterochromatin organization. go.json http://purl.obolibrary.org/obo/GO_0120261 GO:0120277 biolink:BiologicalProcess positive regulation of cerebral blood circulation Any process that activates or increases the frequency, rate or extent of cerebral blood circulation. go.json activation of cerebral blood circulation|positive regulation of cerebrum blood circulation|positive regulation of telencephalon blood circulation|up regulation of cerebral blood circulation|up-regulation of cerebral blood circulation|upregulation of cerebral blood circulation http://purl.obolibrary.org/obo/GO_0120277 GO:0120278 biolink:BiologicalProcess negative regulation of cerebral blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation. go.json down regulation of cerebral blood circulation|down-regulation of cerebral blood circulation|downregulation of cerebral blood circulation|inhibition of cerebral blood circulation|negative regulation of cerebrum blood circulation|negative regulation of telencephalon blood circulation http://purl.obolibrary.org/obo/GO_0120278 GO:0120279 biolink:CellularComponent Z granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans. go.json germline granule http://purl.obolibrary.org/obo/GO_0120279 GO:0120273 biolink:BiologicalProcess ciliary centrin arm assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules. go.json ciliary centrin arm formation http://purl.obolibrary.org/obo/GO_0120273 GO:0120274 biolink:MolecularActivity virus coreceptor activity Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity. go.json viral coreceptor activity http://purl.obolibrary.org/obo/GO_0120274 goslim_generic GO:0120275 biolink:BiologicalProcess cerebral blood circulation The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products. go.json cerebrum blood circulation|telencephelon blood circulation http://purl.obolibrary.org/obo/GO_0120275 GO:0120276 biolink:BiologicalProcess regulation of cerebral blood circulation Any process that modulates the frequency, rate or extent of cerebral blood circulation. go.json regulation of cerebrum blood circulation|regulation of telencephalon blood circulation http://purl.obolibrary.org/obo/GO_0120276 GO:0120270 biolink:BiologicalProcess regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. go.json http://purl.obolibrary.org/obo/GO_0120270 GO:0120271 biolink:BiologicalProcess negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. go.json http://purl.obolibrary.org/obo/GO_0120271 GO:0120272 biolink:BiologicalProcess positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts Any process that activates or increases the frequency, rate or extent of degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. go.json http://purl.obolibrary.org/obo/GO_0120272 GO:0120288 biolink:BiologicalProcess obsolete negative regulation of aspartic endopeptidase activity, intramembrane cleaving OBSOLETE. Any process that decreases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity. go.json True http://purl.obolibrary.org/obo/GO_0120288 GO:0120289 biolink:BiologicalProcess obsolete positive regulation of aspartic endopeptidase activity, intramembrane cleaving OBSOLETE. Any process that increases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity. go.json True http://purl.obolibrary.org/obo/GO_0120289 GO:0120284 biolink:MolecularActivity tryptophan binding Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid. go.json Trp binding http://purl.obolibrary.org/obo/GO_0120284 GO:0120285 biolink:MolecularActivity tyrosine sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine. go.json tyrosine sensing activity http://purl.obolibrary.org/obo/GO_0120285 GO:0120286 biolink:MolecularActivity tryptophan sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan. go.json tryptophan sensing activity http://purl.obolibrary.org/obo/GO_0120286 GO:0120287 biolink:BiologicalProcess obsolete regulation of aspartic endopeptidase activity, intramembrane cleaving OBSOLETE. Any process that modulates the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity. go.json True http://purl.obolibrary.org/obo/GO_0120287 GO:0120280 biolink:CellularComponent ciliary pro-basal body The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium. go.json flagellar pro-basal body|flagellar probasal body|pro-basal body|pro-centriole|probasal body http://purl.obolibrary.org/obo/GO_0120280 GO:0120281 biolink:CellularComponent autolysosome membrane A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded. go.json http://purl.obolibrary.org/obo/GO_0120281 GO:0120282 biolink:CellularComponent autolysosome lumen The volume that is enclosed within the autolysosome single-membrane. go.json http://purl.obolibrary.org/obo/GO_0120282 GO:0120283 biolink:MolecularActivity protein serine/threonine kinase binding Binding to a protein serine/threonine kinase. go.json http://purl.obolibrary.org/obo/GO_0120283 GO:1901169 biolink:BiologicalProcess 3-chlorocatechol biosynthetic process The chemical reactions and pathways resulting in the formation of 3-chlorocatechol. go.json 3-chlorocatechol anabolism|3-chlorocatechol biosynthesis|3-chlorocatechol formation|3-chlorocatechol synthesis http://purl.obolibrary.org/obo/GO_1901169 GO:1901167 biolink:BiologicalProcess 3-chlorocatechol metabolic process The chemical reactions and pathways involving 3-chlorocatechol. go.json 3-chlorocatechol metabolism http://purl.obolibrary.org/obo/GO_1901167 GO:1901168 biolink:BiologicalProcess 3-chlorocatechol catabolic process The chemical reactions and pathways resulting in the breakdown of 3-chlorocatechol. go.json 3-chlorocatechol breakdown|3-chlorocatechol catabolism|3-chlorocatechol degradation http://purl.obolibrary.org/obo/GO_1901168 GO:1901165 biolink:BiologicalProcess positive regulation of trophoblast cell migration Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. go.json activation of trophoblast cell migration|up regulation of trophoblast cell migration|up-regulation of trophoblast cell migration|upregulation of trophoblast cell migration http://purl.obolibrary.org/obo/GO_1901165 GO:1901166 biolink:BiologicalProcess neural crest cell migration involved in autonomic nervous system development Any neural crest cell migration that is involved in autonomic nervous system development. go.json http://purl.obolibrary.org/obo/GO_1901166 GO:1901174 biolink:BiologicalProcess phytoene biosynthetic process The chemical reactions and pathways resulting in the formation of phytoene. go.json phytoene anabolism|phytoene biosynthesis|phytoene formation|phytoene synthesis http://purl.obolibrary.org/obo/GO_1901174 GO:1901175 biolink:BiologicalProcess lycopene metabolic process The chemical reactions and pathways involving lycopene. go.json lycopene metabolism http://purl.obolibrary.org/obo/GO_1901175 GO:1901172 biolink:BiologicalProcess phytoene metabolic process The chemical reactions and pathways involving phytoene. go.json phytoene metabolism http://purl.obolibrary.org/obo/GO_1901172 GO:1901173 biolink:BiologicalProcess phytoene catabolic process The chemical reactions and pathways resulting in the breakdown of phytoene. go.json phytoene breakdown|phytoene catabolism|phytoene degradation http://purl.obolibrary.org/obo/GO_1901173 GO:1901170 biolink:BiologicalProcess naphthalene catabolic process The chemical reactions and pathways resulting in the breakdown of naphthalene. UM-BBD_pathwayID:naph go.json naphthalene breakdown|naphthalene catabolism|naphthalene degradation|naphthalene metabolic process|naphthalene metabolism http://purl.obolibrary.org/obo/GO_1901170 GO:1901171 biolink:BiologicalProcess obsolete naphthalene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of naphthalene. go.json naphthalene anabolism|naphthalene biosynthesis|naphthalene formation|naphthalene synthesis True http://purl.obolibrary.org/obo/GO_1901171 GO:0061390 biolink:BiologicalProcess positive regulation of direction of cell growth Any process that increases the direction of cell growth. go.json http://purl.obolibrary.org/obo/GO_0061390 GO:0061391 biolink:BiologicalProcess negative regulation of direction of cell growth Any process that decreases the direction of cell growth. go.json http://purl.obolibrary.org/obo/GO_0061391 GO:0061392 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to osmotic stress OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0061392 GO:0061393 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0061393 GO:0061394 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. go.json True http://purl.obolibrary.org/obo/GO_0061394 GO:1901178 biolink:BiologicalProcess spheroidene metabolic process The chemical reactions and pathways involving spheroidene. go.json spheroidene metabolism http://purl.obolibrary.org/obo/GO_1901178 GO:0061395 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. go.json True http://purl.obolibrary.org/obo/GO_0061395 GO:1901179 biolink:BiologicalProcess spheroidene catabolic process The chemical reactions and pathways resulting in the breakdown of spheroidene. go.json spheroidene breakdown|spheroidene catabolism|spheroidene degradation http://purl.obolibrary.org/obo/GO_1901179 GO:1901176 biolink:BiologicalProcess lycopene catabolic process The chemical reactions and pathways resulting in the breakdown of lycopene. go.json lycopene breakdown|lycopene catabolism|lycopene degradation http://purl.obolibrary.org/obo/GO_1901176 GO:0061396 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061396 GO:1901177 biolink:BiologicalProcess lycopene biosynthetic process The chemical reactions and pathways resulting in the formation of lycopene. go.json lycopene anabolism|lycopene biosynthesis|lycopene formation|lycopene synthesis http://purl.obolibrary.org/obo/GO_1901177 GO:0061397 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to copper ion OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061397 GO:1901185 biolink:BiologicalProcess negative regulation of ERBB signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. go.json down regulation of EGF receptor family signaling pathway|down regulation of EGFR family signaling pathway|down regulation of ERBB signaling pathway|down regulation of ERBB signalling pathway|down regulation of ErbB signaling|down-regulation of EGF receptor family signaling pathway|down-regulation of EGFR family signaling pathway|down-regulation of ERBB signaling pathway|down-regulation of ERBB signalling pathway|down-regulation of ErbB signaling|downregulation of EGF receptor family signaling pathway|downregulation of EGFR family signaling pathway|downregulation of ERBB signaling pathway|downregulation of ERBB signalling pathway|downregulation of ErbB signaling|inhibition of EGF receptor family signaling pathway|inhibition of EGFR family signaling pathway|inhibition of ERBB signaling pathway|inhibition of ERBB signalling pathway|inhibition of ErbB signaling|negative regulation of EGF receptor family signaling pathway|negative regulation of EGFR family signaling pathway|negative regulation of ERBB signalling pathway|negative regulation of ErbB signaling http://purl.obolibrary.org/obo/GO_1901185 GO:0061398 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter in response to copper ion OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061398 GO:1901186 biolink:BiologicalProcess positive regulation of ERBB signaling pathway Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. go.json activation of EGF receptor family signaling pathway|activation of EGFR family signaling pathway|activation of ERBB signaling pathway|activation of ERBB signalling pathway|activation of ErbB signaling|positive regulation of EGF receptor family signaling pathway|positive regulation of EGFR family signaling pathway|positive regulation of ERBB signalling pathway|positive regulation of ErbB signaling|up regulation of EGF receptor family signaling pathway|up regulation of EGFR family signaling pathway|up regulation of ERBB signaling pathway|up regulation of ERBB signalling pathway|up regulation of ErbB signaling|up-regulation of EGF receptor family signaling pathway|up-regulation of EGFR family signaling pathway|up-regulation of ERBB signaling pathway|up-regulation of ERBB signalling pathway|up-regulation of ErbB signaling|upregulation of EGF receptor family signaling pathway|upregulation of EGFR family signaling pathway|upregulation of ERBB signaling pathway|upregulation of ERBB signalling pathway|upregulation of ErbB signaling http://purl.obolibrary.org/obo/GO_1901186 GO:0061399 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061399 GO:1901183 biolink:BiologicalProcess positive regulation of camalexin biosynthetic process Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process. go.json activation of camalexin anabolism|activation of camalexin biosynthesis|activation of camalexin biosynthetic process|activation of camalexin formation|activation of camalexin synthesis|positive regulation of camalexin anabolism|positive regulation of camalexin biosynthesis|positive regulation of camalexin formation|positive regulation of camalexin synthesis|up regulation of camalexin anabolism|up regulation of camalexin biosynthesis|up regulation of camalexin biosynthetic process|up regulation of camalexin formation|up regulation of camalexin synthesis|up-regulation of camalexin anabolism|up-regulation of camalexin biosynthesis|up-regulation of camalexin biosynthetic process|up-regulation of camalexin formation|up-regulation of camalexin synthesis|upregulation of camalexin anabolism|upregulation of camalexin biosynthesis|upregulation of camalexin biosynthetic process|upregulation of camalexin formation|upregulation of camalexin synthesis http://purl.obolibrary.org/obo/GO_1901183 GO:1901184 biolink:BiologicalProcess regulation of ERBB signaling pathway Any process that modulates the frequency, rate or extent of ERBB signaling pathway. go.json regulation of EGF receptor family signaling pathway|regulation of EGFR family signaling pathway|regulation of ERBB signalling pathway|regulation of ErbB signaling http://purl.obolibrary.org/obo/GO_1901184 GO:1901181 biolink:BiologicalProcess negative regulation of cellular response to caffeine Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to caffeine. go.json down regulation of cellular response to caffeine|down-regulation of cellular response to caffeine|downregulation of cellular response to caffeine|inhibition of cellular response to caffeine http://purl.obolibrary.org/obo/GO_1901181 GO:1901182 biolink:BiologicalProcess regulation of camalexin biosynthetic process Any process that modulates the frequency, rate or extent of camalexin biosynthetic process. go.json regulation of camalexin anabolism|regulation of camalexin biosynthesis|regulation of camalexin formation|regulation of camalexin synthesis http://purl.obolibrary.org/obo/GO_1901182 GO:1901180 biolink:BiologicalProcess spheroidene biosynthetic process The chemical reactions and pathways resulting in the formation of spheroidene. go.json spheroidene anabolism|spheroidene biosynthesis|spheroidene formation|spheroidene synthesis http://purl.obolibrary.org/obo/GO_1901180 GO:1901189 biolink:BiologicalProcess positive regulation of ephrin receptor signaling pathway Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway. go.json activation of Eph receptor signaling pathway|activation of Eph receptor signalling pathway|activation of ephrin receptor signaling pathway|positive regulation of Eph receptor signaling pathway|positive regulation of Eph receptor signalling pathway|up regulation of Eph receptor signaling pathway|up regulation of Eph receptor signalling pathway|up regulation of ephrin receptor signaling pathway|up-regulation of Eph receptor signaling pathway|up-regulation of Eph receptor signalling pathway|up-regulation of ephrin receptor signaling pathway|upregulation of Eph receptor signaling pathway|upregulation of Eph receptor signalling pathway|upregulation of ephrin receptor signaling pathway http://purl.obolibrary.org/obo/GO_1901189 GO:1901187 biolink:BiologicalProcess regulation of ephrin receptor signaling pathway Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway. go.json regulation of Eph receptor signaling pathway|regulation of Eph receptor signalling pathway http://purl.obolibrary.org/obo/GO_1901187 GO:1901188 biolink:BiologicalProcess negative regulation of ephrin receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway. go.json down regulation of Eph receptor signaling pathway|down regulation of Eph receptor signalling pathway|down regulation of ephrin receptor signaling pathway|down-regulation of Eph receptor signaling pathway|down-regulation of Eph receptor signalling pathway|down-regulation of ephrin receptor signaling pathway|downregulation of Eph receptor signaling pathway|downregulation of Eph receptor signalling pathway|downregulation of ephrin receptor signaling pathway|inhibition of Eph receptor signaling pathway|inhibition of Eph receptor signalling pathway|inhibition of ephrin receptor signaling pathway|negative regulation of Eph receptor signaling pathway|negative regulation of Eph receptor signalling pathway http://purl.obolibrary.org/obo/GO_1901188 GO:1901196 biolink:BiologicalProcess positive regulation of calcium-mediated signaling involved in cellular response to salt stress Any positive regulation of calcium-mediated signaling that is involved in cellular response to salt stress. go.json activation of calcium-mediated signaling involved in cellular response to ionic osmotic stress|activation of calcium-mediated signaling involved in cellular response to salt stress|activation of calcium-mediated signaling involved in cellular salinity response|positive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress|positive regulation of calcium-mediated signaling involved in cellular salinity response|positive regulation of calcium-mediated signalling involved in cellular response to ionic osmotic stress|positive regulation of calcium-mediated signalling involved in cellular response to salt stress|positive regulation of calcium-mediated signalling involved in cellular salinity response|stimulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress|stimulation of calcium-mediated signaling involved in cellular response to salt stress|stimulation of calcium-mediated signaling involved in cellular salinity response|up regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress|up regulation of calcium-mediated signaling involved in cellular response to salt stress|up regulation of calcium-mediated signaling involved in cellular salinity response|up-regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress|up-regulation of calcium-mediated signaling involved in cellular response to salt stress|up-regulation of calcium-mediated signaling involved in cellular salinity response|upregulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress|upregulation of calcium-mediated signaling involved in cellular response to salt stress|upregulation of calcium-mediated signaling involved in cellular salinity response http://purl.obolibrary.org/obo/GO_1901196 GO:1901197 biolink:BiologicalProcess positive regulation of calcium-mediated signaling involved in cellular response to calcium ion Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion. go.json activation of calcium-mediated signaling involved in cellular response to Ca2+ ion|activation of calcium-mediated signaling involved in cellular response to calcium ion|positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion|positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion|positive regulation of calcium-mediated signalling involved in cellular response to calcium ion|stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion|stimulation of calcium-mediated signaling involved in cellular response to calcium ion|up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion|up regulation of calcium-mediated signaling involved in cellular response to calcium ion|up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion|up-regulation of calcium-mediated signaling involved in response to calcium ion|upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion|upregulation of calcium-mediated signaling involved in cellular response to calcium ion http://purl.obolibrary.org/obo/GO_1901197 GO:1901194 biolink:BiologicalProcess negative regulation of formation of translation preinitiation complex Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex. go.json down regulation of formation of translation pre-initiation complex|down regulation of formation of translation preinitiation complex|down regulation of translation preinitiation complex assembly|down-regulation of formation of translation pre-initiation complex|down-regulation of formation of translation preinitiation complex|down-regulation of translation preinitiation complex assembly|downregulation of formation of translation pre-initiation complex|downregulation of formation of translation preinitiation complex|downregulation of translation preinitiation complex assembly|inhibition of formation of translation pre-initiation complex|inhibition of formation of translation preinitiation complex|inhibition of translation preinitiation complex assembly|negative regulation of formation of translation pre-initiation complex|negative regulation of translation preinitiation complex assembly http://purl.obolibrary.org/obo/GO_1901194 GO:1901195 biolink:BiologicalProcess positive regulation of formation of translation preinitiation complex Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex. go.json activation of formation of translation pre-initiation complex|activation of formation of translation preinitiation complex|activation of translation preinitiation complex assembly|positive regulation of formation of translation pre-initiation complex|positive regulation of translation preinitiation complex assembly|up regulation of formation of translation pre-initiation complex|up regulation of formation of translation preinitiation complex|up regulation of translation preinitiation complex assembly|up-regulation of formation of translation pre-initiation complex|up-regulation of formation of translation preinitiation complex|up-regulation of translation preinitiation complex assembly|upregulation of formation of translation pre-initiation complex|upregulation of formation of translation preinitiation complex|upregulation of translation preinitiation complex assembly http://purl.obolibrary.org/obo/GO_1901195 GO:1901192 biolink:BiologicalProcess positive regulation of formation of translation initiation ternary complex Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. go.json activation of formation of translation initiation ternary complex|activation of translation initiation ternary complex assembly|positive regulation of translation initiation ternary complex assembly|up regulation of formation of translation initiation ternary complex|up regulation of translation initiation ternary complex assembly|up-regulation of formation of translation initiation ternary complex|up-regulation of translation initiation ternary complex assembly|upregulation of formation of translation initiation ternary complex|upregulation of translation initiation ternary complex assembly http://purl.obolibrary.org/obo/GO_1901192 GO:1901193 biolink:BiologicalProcess regulation of formation of translation preinitiation complex Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex. go.json regulation of formation of translation pre-initiation complex|regulation of translation preinitiation complex assembly http://purl.obolibrary.org/obo/GO_1901193 GO:1901190 biolink:BiologicalProcess regulation of formation of translation initiation ternary complex Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. go.json regulation of translation initiation ternary complex assembly http://purl.obolibrary.org/obo/GO_1901190 GO:1901191 biolink:BiologicalProcess negative regulation of formation of translation initiation ternary complex Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. go.json down regulation of formation of translation initiation ternary complex|down regulation of translation initiation ternary complex assembly|down-regulation of formation of translation initiation ternary complex|down-regulation of translation initiation ternary complex assembly|downregulation of formation of translation initiation ternary complex|downregulation of translation initiation ternary complex assembly|inhibition of formation of translation initiation ternary complex|inhibition of translation initiation ternary complex assembly|negative regulation of translation initiation ternary complex assembly http://purl.obolibrary.org/obo/GO_1901191 GO:1901198 biolink:BiologicalProcess positive regulation of calcium ion transport into cytosol involved in cellular response to calcium ion Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to calcium ion. go.json positive regulation of calcium ion transport into cytosol involved in cellular response to Ca2+ ion http://purl.obolibrary.org/obo/GO_1901198 GO:1901199 biolink:BiologicalProcess positive regulation of calcium ion transport into cytosol involved in cellular response to salt stress Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress. go.json positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress|positive regulation of calcium ion transport into cytosol involved in cellular salinity response http://purl.obolibrary.org/obo/GO_1901199 GO:0051995 biolink:MolecularActivity Se-methyltransferase activity Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0051995 GO:0051996 biolink:MolecularActivity squalene synthase activity Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate. EC:2.5.1.21|MetaCyc:RXN66-281 go.json squalene synthetase activity http://purl.obolibrary.org/obo/GO_0051996 GO:0051993 biolink:MolecularActivity abscisic acid glucose ester beta-glucosidase activity Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose. EC:3.2.1.175|MetaCyc:RXN-11469|RHEA:31347 go.json ABA-GE beta-glucosidase activity http://purl.obolibrary.org/obo/GO_0051993 GO:0051994 biolink:MolecularActivity P-methyltransferase activity Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0051994 GO:0051999 biolink:BiologicalProcess mannosyl-inositol phosphorylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative. go.json MIPC biosynthetic process|mannose inositol phosphoceramide biosynthetic process|mannose-inositol-P-ceramide (MIPC) biosynthetic process|mannosyl-inositol phosphorylceramide anabolism|mannosyl-inositol phosphorylceramide biosynthesis|mannosyl-inositol phosphorylceramide formation|mannosyl-inositol phosphorylceramide synthesis http://purl.obolibrary.org/obo/GO_0051999 GO:0051997 biolink:MolecularActivity 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2. EC:4.1.1.97|KEGG_REACTION:R06604|MetaCyc:RXN-6201|RHEA:26301 go.json 4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity|OHCU decarboxylase activity http://purl.obolibrary.org/obo/GO_0051997 GO:0051998 biolink:MolecularActivity protein carboxyl O-methyltransferase activity Catalysis of the transfer of a methyl group to a carboxyl group on a protein. go.json protein carboxyl methyltransferase activity http://purl.obolibrary.org/obo/GO_0051998 GO:2000104 biolink:BiologicalProcess negative regulation of DNA-templated DNA replication Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. go.json negative regulation of DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_2000104 GO:2000105 biolink:BiologicalProcess positive regulation of DNA-templated DNA replication Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication. go.json positive regulation of DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_2000105 GO:2000106 biolink:BiologicalProcess regulation of leukocyte apoptotic process Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. go.json regulation of leukocyte apoptosis http://purl.obolibrary.org/obo/GO_2000106 GO:2000107 biolink:BiologicalProcess negative regulation of leukocyte apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. go.json negative regulation of leukocyte apoptosis http://purl.obolibrary.org/obo/GO_2000107 GO:2000108 biolink:BiologicalProcess positive regulation of leukocyte apoptotic process Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. go.json positive regulation of leukocyte apoptosis http://purl.obolibrary.org/obo/GO_2000108 GO:2000109 biolink:BiologicalProcess regulation of macrophage apoptotic process Any process that modulates the frequency, rate or extent of macrophage apoptotic process. go.json regulation of AICD|regulation of activation-induced cell death|regulation of macrophage apoptosis http://purl.obolibrary.org/obo/GO_2000109 GO:0061320 biolink:BiologicalProcess pericardial nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. go.json pericardial cell differentiation http://purl.obolibrary.org/obo/GO_0061320 GO:0036354 biolink:MolecularActivity 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+. MetaCyc:RXN-8787|RHEA:19733 go.json http://purl.obolibrary.org/obo/GO_0036354 GO:0061321 biolink:BiologicalProcess garland nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. go.json garland cell differentiation http://purl.obolibrary.org/obo/GO_0061321 GO:0036355 biolink:MolecularActivity 2-iminoacetate synthase activity Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+. EC:4.1.99.19|MetaCyc:RXN-11319|RHEA:26361 go.json http://purl.obolibrary.org/obo/GO_0036355 GO:0061322 biolink:BiologicalProcess disseminated nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061322 GO:0036356 biolink:MolecularActivity cyclic 2,3-diphosphoglycerate synthetase activity Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate. go.json CPGS activity|cDPGS activity http://purl.obolibrary.org/obo/GO_0036356 GO:0061323 biolink:BiologicalProcess cell proliferation involved in heart morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0061323 GO:0061324 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells. go.json canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation|canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation http://purl.obolibrary.org/obo/GO_0061324 GO:0036357 biolink:MolecularActivity 2-phosphoglycerate kinase activity Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP. EC:2.7.2.- go.json 2PGK activity http://purl.obolibrary.org/obo/GO_0036357 GO:0061325 biolink:BiologicalProcess cell proliferation involved in outflow tract morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. go.json http://purl.obolibrary.org/obo/GO_0061325 GO:2000100 biolink:BiologicalProcess regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000100 GO:0036358 biolink:BiologicalProcess lipoteichoic acid D-alanylation The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA). go.json D-alanyl LTA formation|D-alanyl lipoteichoic acid formation|LTA D-alanylation http://purl.obolibrary.org/obo/GO_0036358 GO:2000101 biolink:BiologicalProcess regulation of mammary stem cell proliferation Any process that modulates the frequency, rate or extent of mammary stem cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000101 GO:0061326 biolink:BiologicalProcess renal tubule development The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. go.json http://purl.obolibrary.org/obo/GO_0061326 GO:0036359 biolink:BiologicalProcess renal potassium excretion The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. go.json renal K(+) excretion|renal K+ elimination|renal potassium ion excretion http://purl.obolibrary.org/obo/GO_0036359 GO:2000102 biolink:BiologicalProcess negative regulation of mammary stem cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000102 GO:0061327 biolink:BiologicalProcess anterior Malpighian tubule development The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut. go.json http://purl.obolibrary.org/obo/GO_0061327 GO:0061328 biolink:BiologicalProcess posterior Malpighian tubule development The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut. go.json http://purl.obolibrary.org/obo/GO_0061328 GO:2000103 biolink:BiologicalProcess positive regulation of mammary stem cell proliferation Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000103 GO:0061329 biolink:BiologicalProcess Malpighian tubule principal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule. go.json http://purl.obolibrary.org/obo/GO_0061329 GO:0051991 biolink:MolecularActivity UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP. EC:2.4.1.227|MetaCyc:NACGLCTRANS-RXN|RHEA:31227 go.json http://purl.obolibrary.org/obo/GO_0051991 GO:0036350 biolink:BiologicalProcess mannose-specific flocculation The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other. go.json cell-cell adhesion involved in mannose-specific flocculation http://purl.obolibrary.org/obo/GO_0036350 GO:0036351 biolink:BiologicalProcess histone H2A-K13 ubiquitination The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin. go.json histone H2A ubiquitination (H2A-K13) http://purl.obolibrary.org/obo/GO_0036351 gocheck_do_not_annotate GO:0051992 biolink:MolecularActivity UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol. EC:2.7.8.13|MetaCyc:PHOSNACMURPENTATRANS-RXN|RHEA:28386 go.json http://purl.obolibrary.org/obo/GO_0051992 goslim_chembl GO:0036352 biolink:BiologicalProcess histone H2A-K15 ubiquitination The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin. go.json histone H2A ubiquitination (H2A-K15) http://purl.obolibrary.org/obo/GO_0036352 gocheck_do_not_annotate GO:0036353 biolink:BiologicalProcess histone H2A-K119 monoubiquitination The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. go.json histone H2A monoubiquitination (H2A-K119) http://purl.obolibrary.org/obo/GO_0036353 gocheck_do_not_annotate GO:0051990 biolink:MolecularActivity (R)-2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. EC:1.1.99.39|RHEA:38295|Reactome:R-HSA-880007|Reactome:R-HSA-880053 go.json D-2-hydroxyglutarate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0051990 GO:2000115 biolink:BiologicalProcess regulation of maintenance of bipolar cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape. go.json http://purl.obolibrary.org/obo/GO_2000115 GO:2000116 biolink:BiologicalProcess regulation of cysteine-type endopeptidase activity Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. go.json regulation of lysosomal cysteine-type endopeptidase|regulation of thiol endopeptidase activity http://purl.obolibrary.org/obo/GO_2000116 gocheck_do_not_annotate GO:2000117 biolink:BiologicalProcess negative regulation of cysteine-type endopeptidase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. go.json negative regulation of lysosomal cysteine-type endopeptidase|negative regulation of thiol endopeptidase activity http://purl.obolibrary.org/obo/GO_2000117 gocheck_do_not_annotate GO:2000118 biolink:BiologicalProcess regulation of sodium-dependent phosphate transport Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport. go.json http://purl.obolibrary.org/obo/GO_2000118 GO:2000119 biolink:BiologicalProcess negative regulation of sodium-dependent phosphate transport Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport. go.json http://purl.obolibrary.org/obo/GO_2000119 GO:0061310 biolink:BiologicalProcess canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation. go.json canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development|canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development|canonical Wnt-activated signaling pathway involved in cardiac neural crest cell differentiation involved in heart development http://purl.obolibrary.org/obo/GO_0061310 GO:0036343 biolink:BiologicalProcess psychomotor behavior The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. go.json http://purl.obolibrary.org/obo/GO_0036343 GO:0061311 biolink:BiologicalProcess cell surface receptor signaling pathway involved in heart development The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time. go.json cell surface receptor linked signaling pathway involved in heart development|cell surface receptor linked signalling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0061311 GO:0036344 biolink:BiologicalProcess platelet morphogenesis Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. go.json http://purl.obolibrary.org/obo/GO_0036344 GO:0061312 biolink:BiologicalProcess obsolete BMP signaling pathway involved in heart development OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the progression of the heart over time. go.json BMP signalling pathway involved in heart development True http://purl.obolibrary.org/obo/GO_0061312 GO:0036345 biolink:BiologicalProcess platelet maturation A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. go.json http://purl.obolibrary.org/obo/GO_0036345 GO:0061313 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in heart development The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time. go.json fibroblast growth factor receptor signalling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0061313 GO:0036346 biolink:BiologicalProcess cellular response to L-cysteine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration. go.json http://purl.obolibrary.org/obo/GO_0036346 GO:2000110 biolink:BiologicalProcess negative regulation of macrophage apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. go.json negative regulation of AICD|negative regulation of activation-induced cell death|negative regulation of macrophage apoptosis http://purl.obolibrary.org/obo/GO_2000110 GO:2000111 biolink:BiologicalProcess positive regulation of macrophage apoptotic process Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. go.json positive regulation of AICD|positive regulation of activation-induced cell death|positive regulation of macrophage apoptosis http://purl.obolibrary.org/obo/GO_2000111 GO:0061314 biolink:BiologicalProcess Notch signaling involved in heart development The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time. go.json Notch signalling involved in heart development http://purl.obolibrary.org/obo/GO_0061314 GO:0036347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036347 GO:2000112 biolink:BiologicalProcess obsolete regulation of cellular macromolecule biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. go.json regulation of cellular biopolymer biosynthetic process|regulation of cellular macromolecule anabolism|regulation of cellular macromolecule biosynthesis|regulation of cellular macromolecule formation|regulation of cellular macromolecule synthesis True http://purl.obolibrary.org/obo/GO_2000112 GO:0061315 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells. go.json canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation|canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation http://purl.obolibrary.org/obo/GO_0061315 GO:0036348 biolink:MolecularActivity hydantoin racemase activity Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin. EC:5.1.99.5|KEGG_REACTION:R09704|MetaCyc:RXN-9781|RHEA:46624 go.json http://purl.obolibrary.org/obo/GO_0036348 GO:2000113 biolink:BiologicalProcess obsolete negative regulation of cellular macromolecule biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. go.json negative regulation of cellular biopolymer biosynthetic process|negative regulation of cellular macromolecule anabolism|negative regulation of cellular macromolecule biosynthesis|negative regulation of cellular macromolecule formation|negative regulation of cellular macromolecule synthesis True http://purl.obolibrary.org/obo/GO_2000113 GO:0061316 biolink:BiologicalProcess canonical Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json canonical Wnt receptor signaling pathway involved in heart development|canonical Wnt receptor signalling pathway involved in heart development|canonical Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0061316 GO:0036349 biolink:BiologicalProcess galactose-specific flocculation The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other. go.json cell-cell adhesion involved in galactose-specific flocculation http://purl.obolibrary.org/obo/GO_0036349 GO:0061317 biolink:BiologicalProcess canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment http://purl.obolibrary.org/obo/GO_0061317 GO:2000114 biolink:BiologicalProcess regulation of establishment of cell polarity Any process that modulates the frequency, rate or extent of establishment of cell polarity. go.json regulation of bud site selection/establishment of cell polarity|regulation of cell polarization http://purl.obolibrary.org/obo/GO_2000114 GO:0061318 biolink:BiologicalProcess renal filtration cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061318 GO:0061319 biolink:BiologicalProcess nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061319 GO:0036340 biolink:BiologicalProcess chitin-based cuticle sclerotization by biomineralization The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate. go.json chitin-based cuticle hardening by biomineralisation http://purl.obolibrary.org/obo/GO_0036340 GO:0036341 biolink:BiologicalProcess chitin-based cuticle sclerotization by protein cross-linking The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle. go.json chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning http://purl.obolibrary.org/obo/GO_0036341 GO:0036342 biolink:BiologicalProcess post-anal tail morphogenesis The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. go.json http://purl.obolibrary.org/obo/GO_0036342 GO:1901109 biolink:BiologicalProcess granaticin biosynthetic process The chemical reactions and pathways resulting in the formation of granaticin. go.json granaticin anabolism|granaticin biosynthesis|granaticin formation|granaticin synthesis http://purl.obolibrary.org/obo/GO_1901109 GO:1901107 biolink:BiologicalProcess granaticin metabolic process The chemical reactions and pathways involving granaticin. go.json granaticin metabolism http://purl.obolibrary.org/obo/GO_1901107 GO:1901108 biolink:BiologicalProcess granaticin catabolic process The chemical reactions and pathways resulting in the breakdown of granaticin. go.json granaticin breakdown|granaticin catabolism|granaticin degradation http://purl.obolibrary.org/obo/GO_1901108 GO:1901105 biolink:BiologicalProcess tetracenomycin C catabolic process The chemical reactions and pathways resulting in the breakdown of tetracenomycin C. go.json tetracenomycin C breakdown|tetracenomycin C catabolism|tetracenomycin C degradation http://purl.obolibrary.org/obo/GO_1901105 GO:2000126 biolink:BiologicalProcess negative regulation of octopamine or tyramine signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway. go.json negative regulation of octopamine or tyramine signalling pathway|negative regulation of octopamine/tyramine signaling pathway http://purl.obolibrary.org/obo/GO_2000126 GO:1901106 biolink:BiologicalProcess tetracenomycin C biosynthetic process The chemical reactions and pathways resulting in the formation of tetracenomycin C. go.json tetracenomycin C anabolism|tetracenomycin C biosynthesis|tetracenomycin C formation|tetracenomycin C synthesis http://purl.obolibrary.org/obo/GO_1901106 GO:2000127 biolink:BiologicalProcess positive regulation of octopamine or tyramine signaling pathway Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway. go.json positive regulation of octopamine or tyramine signalling pathway|positive regulation of octopamine/tyramine signaling pathway http://purl.obolibrary.org/obo/GO_2000127 GO:1901103 biolink:BiologicalProcess gramicidin S biosynthetic process The chemical reactions and pathways resulting in the formation of gramicidin S. go.json gramicidin S anabolism|gramicidin S biosynthesis|gramicidin S formation|gramicidin S synthesis http://purl.obolibrary.org/obo/GO_1901103 GO:2000128 biolink:BiologicalProcess regulation of octopamine signaling pathway Any process that modulates the frequency, rate or extent of octopamine signaling pathway. go.json regulation of octopamine signalling pathway http://purl.obolibrary.org/obo/GO_2000128 GO:2000129 biolink:BiologicalProcess negative regulation of octopamine signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway. go.json negative regulation of octopamine signalling pathway http://purl.obolibrary.org/obo/GO_2000129 GO:1901104 biolink:BiologicalProcess tetracenomycin C metabolic process The chemical reactions and pathways involving tetracenomycin C. go.json tetracenomycin C metabolism http://purl.obolibrary.org/obo/GO_1901104 GO:1901101 biolink:BiologicalProcess gramicidin S metabolic process The chemical reactions and pathways involving gramicidin S. go.json gramicidin S metabolism http://purl.obolibrary.org/obo/GO_1901101 GO:0061340 biolink:BiologicalProcess establishment or maintenance of monopolar cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell. go.json http://purl.obolibrary.org/obo/GO_0061340 GO:1901102 biolink:BiologicalProcess gramicidin S catabolic process The chemical reactions and pathways resulting in the breakdown of gramicidin S. go.json gramicidin S breakdown|gramicidin S catabolism|gramicidin S degradation http://purl.obolibrary.org/obo/GO_1901102 GO:0061341 biolink:BiologicalProcess non-canonical Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time. go.json non-canonical Wnt receptor signaling pathway involved in heart development|non-canonical Wnt receptor signalling pathway involved in heart development|non-canonical Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0061341 GO:0061342 biolink:BiologicalProcess regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart. go.json regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway http://purl.obolibrary.org/obo/GO_0061342 GO:0036332 biolink:MolecularActivity placental growth factor receptor activity Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json PlGF receptor activity|PlGF-activated receptor activity|placental growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0036332 GO:0061343 biolink:BiologicalProcess cell adhesion involved in heart morphogenesis The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0061343 GO:0061344 biolink:BiologicalProcess regulation of cell adhesion involved in heart morphogenesis Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0061344 GO:0036333 biolink:BiologicalProcess hepatocyte homeostasis Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. go.json http://purl.obolibrary.org/obo/GO_0036333 GO:2000120 biolink:BiologicalProcess positive regulation of sodium-dependent phosphate transport Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport. go.json http://purl.obolibrary.org/obo/GO_2000120 GO:0036334 biolink:BiologicalProcess epidermal stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. go.json http://purl.obolibrary.org/obo/GO_0036334 GO:0061345 biolink:BiologicalProcess planar cell polarity pathway involved in cardiac muscle cell fate commitment The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate. go.json http://purl.obolibrary.org/obo/GO_0061345 GO:0061346 biolink:BiologicalProcess planar cell polarity pathway involved in heart morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0061346 GO:2000121 biolink:BiologicalProcess regulation of removal of superoxide radicals Any process that modulates the frequency, rate or extent of removal of superoxide radicals. go.json regulation of removal of O2-|regulation of removal of oxygen free radicals http://purl.obolibrary.org/obo/GO_2000121 GO:0036335 biolink:BiologicalProcess intestinal stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. go.json intestinal crypt stem cell homeostasis http://purl.obolibrary.org/obo/GO_0036335 GO:0061347 biolink:BiologicalProcess planar cell polarity pathway involved in outflow tract morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract. go.json http://purl.obolibrary.org/obo/GO_0061347 GO:2000122 biolink:BiologicalProcess negative regulation of stomatal complex development Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development. go.json http://purl.obolibrary.org/obo/GO_2000122 GO:0036336 biolink:BiologicalProcess dendritic cell migration The movement of a dendritic cell within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0036336 GO:0061348 biolink:BiologicalProcess planar cell polarity pathway involved in ventricular septum morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum. go.json http://purl.obolibrary.org/obo/GO_0061348 GO:0036337 biolink:BiologicalProcess Fas signaling pathway The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily. go.json Apo-1 signaling pathway|CD95 signaling pathway|FAS ligand-Fas signaling pathway|Fas receptor signaling pathway|Fas-FasL signaling pathway|FasL signaling pathway|FasR signaling pathway http://purl.obolibrary.org/obo/GO_0036337 GO:2000123 biolink:BiologicalProcess positive regulation of stomatal complex development Any process that activates or increases the frequency, rate or extent of stomatal complex development. go.json http://purl.obolibrary.org/obo/GO_2000123 GO:2000124 biolink:BiologicalProcess regulation of endocannabinoid signaling pathway Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway. go.json regulation of endocannabinoid signalling pathway http://purl.obolibrary.org/obo/GO_2000124 GO:0061349 biolink:BiologicalProcess planar cell polarity pathway involved in cardiac right atrium morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium. go.json http://purl.obolibrary.org/obo/GO_0061349 GO:0036338 biolink:CellularComponent viral membrane The lipid bilayer of a virion, a complete fully infectious extracellular virus particle. go.json http://purl.obolibrary.org/obo/GO_0036338 GO:2000125 biolink:BiologicalProcess regulation of octopamine or tyramine signaling pathway Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway. go.json regulation of octopamine or tyramine signalling pathway|regulation of octopamine/tyramine signaling pathway http://purl.obolibrary.org/obo/GO_2000125 GO:0036339 biolink:BiologicalProcess lymphocyte adhesion to endothelial cell of high endothelial venule The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream. go.json lymphocyte adhesion to HEV cell|lymphocyte adhesion to high endothelial venule http://purl.obolibrary.org/obo/GO_0036339 GO:0036330 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036330 GO:0036331 biolink:BiologicalProcess avascular cornea development in camera-type eye The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees. go.json avascular cornea development http://purl.obolibrary.org/obo/GO_0036331 GO:1901118 biolink:BiologicalProcess cephamycin C biosynthetic process The chemical reactions and pathways resulting in the formation of cephamycin C. go.json cephamycin C anabolism|cephamycin C biosynthesis|cephamycin C formation|cephamycin C synthesis http://purl.obolibrary.org/obo/GO_1901118 GO:1901119 biolink:BiologicalProcess tobramycin metabolic process The chemical reactions and pathways involving tobramycin. go.json tobramycin metabolism http://purl.obolibrary.org/obo/GO_1901119 GO:1901116 biolink:BiologicalProcess cephamycin C metabolic process The chemical reactions and pathways involving cephamycin C. go.json cephamycin C metabolism http://purl.obolibrary.org/obo/GO_1901116 GO:2000137 biolink:BiologicalProcess negative regulation of cell proliferation involved in heart morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000137 GO:0036329 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036329 GO:1901117 biolink:BiologicalProcess cephamycin C catabolic process The chemical reactions and pathways resulting in the breakdown of cephamycin C. go.json cephamycin C breakdown|cephamycin C catabolism|cephamycin C degradation http://purl.obolibrary.org/obo/GO_1901117 GO:2000138 biolink:BiologicalProcess positive regulation of cell proliferation involved in heart morphogenesis Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000138 GO:1901114 biolink:BiologicalProcess erythromycin catabolic process The chemical reactions and pathways resulting in the breakdown of erythromycin. go.json erythromycin breakdown|erythromycin catabolism|erythromycin degradation http://purl.obolibrary.org/obo/GO_1901114 GO:2000139 biolink:BiologicalProcess regulation of octopamine signaling pathway involved in response to food Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food. go.json regulation of octopamine signalling pathway involved in response to food http://purl.obolibrary.org/obo/GO_2000139 GO:1901115 biolink:BiologicalProcess erythromycin biosynthetic process The chemical reactions and pathways resulting in the formation of erythromycin. go.json erythromycin anabolism|erythromycin biosynthesis|erythromycin formation|erythromycin synthesis http://purl.obolibrary.org/obo/GO_1901115 GO:1901112 biolink:BiologicalProcess actinorhodin biosynthetic process The chemical reactions and pathways resulting in the formation of actinorhodin. go.json actinorhodin anabolism|actinorhodin biosynthesis|actinorhodin formation|actinorhodin synthesis http://purl.obolibrary.org/obo/GO_1901112 GO:1901113 biolink:BiologicalProcess erythromycin metabolic process The chemical reactions and pathways involving erythromycin. go.json erythromycin metabolism http://purl.obolibrary.org/obo/GO_1901113 GO:1901110 biolink:BiologicalProcess actinorhodin metabolic process The chemical reactions and pathways involving actinorhodin. go.json actinorhodin metabolism http://purl.obolibrary.org/obo/GO_1901110 GO:0061330 biolink:BiologicalProcess Malpighian tubule stellate cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium. go.json http://purl.obolibrary.org/obo/GO_0061330 GO:1901111 biolink:BiologicalProcess actinorhodin catabolic process The chemical reactions and pathways resulting in the breakdown of actinorhodin. go.json actinorhodin breakdown|actinorhodin catabolism|actinorhodin degradation http://purl.obolibrary.org/obo/GO_1901111 GO:0061331 biolink:BiologicalProcess epithelial cell proliferation involved in Malpighian tubule morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule. go.json http://purl.obolibrary.org/obo/GO_0061331 GO:0061332 biolink:BiologicalProcess Malpighian tubule bud morphogenesis The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position. go.json Malpighian tubule formation http://purl.obolibrary.org/obo/GO_0061332 GO:0036321 biolink:BiologicalProcess ghrelin secretion The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone. go.json pancreatic ghrelin secretion http://purl.obolibrary.org/obo/GO_0036321 GO:0061333 biolink:BiologicalProcess renal tubule morphogenesis The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. go.json http://purl.obolibrary.org/obo/GO_0061333 GO:1901120 biolink:BiologicalProcess tobramycin catabolic process The chemical reactions and pathways resulting in the breakdown of tobramycin. go.json tobramycin breakdown|tobramycin catabolism|tobramycin degradation http://purl.obolibrary.org/obo/GO_1901120 GO:0036322 biolink:BiologicalProcess pancreatic polypeptide secretion The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas. go.json PP secretion http://purl.obolibrary.org/obo/GO_0036322 GO:2000130 biolink:BiologicalProcess positive regulation of octopamine signaling pathway Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway. go.json positive regulation of octopamine signalling pathway http://purl.obolibrary.org/obo/GO_2000130 GO:0061334 biolink:BiologicalProcess cell rearrangement involved in Malpighian tubule morphogenesis The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule. go.json cell migration involved in Malpighian tubule morphogenesis http://purl.obolibrary.org/obo/GO_0061334 GO:0036323 biolink:BiologicalProcess vascular endothelial growth factor receptor-1 signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json FLT1 signaling pathway|VEGFR-1 signaling pathway|VEGFR1 signaling pathway http://purl.obolibrary.org/obo/GO_0036323 GO:2000131 biolink:BiologicalProcess regulation of tyramine signaling pathway Any process that modulates the frequency, rate or extent of tyramine signaling pathway. go.json regulation of tyramine signalling pathway http://purl.obolibrary.org/obo/GO_2000131 GO:0036324 biolink:BiologicalProcess vascular endothelial growth factor receptor-2 signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json FLK-1 signaling pathway|KDR signaling pathway|VEGFR-2 signaling pathway|VEGFR2 signaling pathway http://purl.obolibrary.org/obo/GO_0036324 GO:0061335 biolink:BiologicalProcess cell growth involved in Malpighian tubule morphogenesis The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule. go.json http://purl.obolibrary.org/obo/GO_0061335 GO:2000132 biolink:BiologicalProcess negative regulation of tyramine signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway. go.json negative regulation of tyramine signalling pathway http://purl.obolibrary.org/obo/GO_2000132 GO:0061336 biolink:BiologicalProcess cell morphogenesis involved in Malpighian tubule morphogenesis The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule. go.json http://purl.obolibrary.org/obo/GO_0061336 GO:2000133 biolink:BiologicalProcess positive regulation of tyramine signaling pathway Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway. go.json positive regulation of tyramine signalling pathway http://purl.obolibrary.org/obo/GO_2000133 GO:0036325 biolink:BiologicalProcess vascular endothelial growth factor receptor-3 signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json FLT4 signaling pathway|VEGFR-3 signaling pathway|VEGFR3 signaling pathway http://purl.obolibrary.org/obo/GO_0036325 GO:0061337 biolink:BiologicalProcess cardiac conduction Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. go.json http://purl.obolibrary.org/obo/GO_0061337 GO:2000134 biolink:BiologicalProcess negative regulation of G1/S transition of mitotic cell cycle Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_2000134 GO:0036326 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036326 GO:2000135 biolink:BiologicalProcess obsolete positive regulation of regulation of secondary heart field cardioblast proliferation OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation. go.json positive regulation of regulation of second heart field cardioblast proliferation|positive regulation of regulation of secondary heart field cardioblast proliferation True http://purl.obolibrary.org/obo/GO_2000135 GO:0061338 biolink:BiologicalProcess obsolete atrioventricular node impulse conduction delay OBSOLETE. A heart process that modulates the propagation of the signal that causes the heart muscle to contract. go.json atrioventricular node impulse conduction delay True http://purl.obolibrary.org/obo/GO_0061338 GO:0036327 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036327 GO:0061339 biolink:BiologicalProcess establishment or maintenance of monopolar cell polarity Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. go.json http://purl.obolibrary.org/obo/GO_0061339 GO:0036328 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036328 GO:2000136 biolink:BiologicalProcess regulation of cell proliferation involved in heart morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000136 GO:0036320 biolink:MolecularActivity mating-type P-factor pheromone receptor activity Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus. go.json P-factor mating pheromone receptor activity|P-factor receptor activity http://purl.obolibrary.org/obo/GO_0036320 GO:1901129 biolink:BiologicalProcess gentamycin catabolic process The chemical reactions and pathways resulting in the breakdown of gentamycin. go.json gentamycin breakdown|gentamycin catabolism|gentamycin degradation http://purl.obolibrary.org/obo/GO_1901129 GO:1901127 biolink:BiologicalProcess candicidin biosynthetic process The chemical reactions and pathways resulting in the formation of candicidin. go.json candicidin anabolism|candicidin biosynthesis|candicidin formation|candicidin synthesis http://purl.obolibrary.org/obo/GO_1901127 GO:0036318 biolink:MolecularActivity peptide pheromone receptor activity Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0036318 GO:0036319 biolink:MolecularActivity mating-type M-factor pheromone receptor activity Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus. go.json M-factor mating pheromone receptor activity|M-factor receptor activity http://purl.obolibrary.org/obo/GO_0036319 GO:1901128 biolink:BiologicalProcess gentamycin metabolic process The chemical reactions and pathways involving gentamycin. go.json gentamycin metabolism http://purl.obolibrary.org/obo/GO_1901128 GO:1901125 biolink:BiologicalProcess candicidin metabolic process The chemical reactions and pathways involving candicidin. go.json candicidin metabolism http://purl.obolibrary.org/obo/GO_1901125 GO:1901126 biolink:BiologicalProcess candicidin catabolic process The chemical reactions and pathways resulting in the breakdown of candicidin. go.json candicidin breakdown|candicidin catabolism|candicidin degradation http://purl.obolibrary.org/obo/GO_1901126 GO:0061360 biolink:BiologicalProcess optic chiasma development The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature. go.json optic chiasm development http://purl.obolibrary.org/obo/GO_0061360 GO:1901123 biolink:BiologicalProcess bacitracin A catabolic process The chemical reactions and pathways resulting in the breakdown of bacitracin A. go.json bacitracin A breakdown|bacitracin A catabolism|bacitracin A degradation http://purl.obolibrary.org/obo/GO_1901123 GO:0061361 biolink:BiologicalProcess positive regulation of maintenance of bipolar cell polarity regulating cell shape Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_0061361 GO:1901124 biolink:BiologicalProcess bacitracin A biosynthetic process The chemical reactions and pathways resulting in the formation of bacitracin A. go.json bacitracin A anabolism|bacitracin A biosynthesis|bacitracin A formation|bacitracin A synthesis http://purl.obolibrary.org/obo/GO_1901124 GO:0061362 biolink:BiologicalProcess negative regulation of maintenance of bipolar cell polarity regulating cell shape Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_0061362 GO:1901121 biolink:BiologicalProcess tobramycin biosynthetic process The chemical reactions and pathways resulting in the formation of tobramycin. go.json tobramycin anabolism|tobramycin biosynthesis|tobramycin formation|tobramycin synthesis http://purl.obolibrary.org/obo/GO_1901121 GO:0061363 biolink:BiologicalProcess negative regulation of progesterone biosynthesis involved in luteolysis Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis. go.json functional luteolysis http://purl.obolibrary.org/obo/GO_0061363 GO:1901122 biolink:BiologicalProcess bacitracin A metabolic process The chemical reactions and pathways involving bacitracin A. go.json bacitracin A metabolism http://purl.obolibrary.org/obo/GO_1901122 GO:0061364 biolink:BiologicalProcess apoptotic process involved in luteolysis The apoptotic process that contributes to luteolysis. go.json apoptosis involved in luteolysis|structural luteolysis http://purl.obolibrary.org/obo/GO_0061364 GO:0036310 biolink:MolecularActivity ATP-dependent DNA/DNA annealing activity An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule. go.json ATP-dependent DNA annealing activity|DNA rewinding activity|annealing helicase activity|nucleoside-triphosphatase activity involved in DNA annealing http://purl.obolibrary.org/obo/GO_0036310 GO:0061365 biolink:BiologicalProcess positive regulation of triglyceride lipase activity Any process that increases the activity of triglyceride lipase. go.json positive regulation of TAG activity http://purl.obolibrary.org/obo/GO_0061365 gocheck_do_not_annotate GO:1901130 biolink:BiologicalProcess gentamycin biosynthetic process The chemical reactions and pathways resulting in the formation of gentamycin. go.json gentamycin anabolism|gentamycin biosynthesis|gentamycin formation|gentamycin synthesis http://purl.obolibrary.org/obo/GO_1901130 GO:0061366 biolink:BiologicalProcess behavioral response to chemical pain Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus. go.json http://purl.obolibrary.org/obo/GO_0061366 GO:0036311 biolink:MolecularActivity chitin disaccharide deacetylase activity Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate. go.json chitin oligosaccharide amidohydrolase activity|chitin oligosaccharide deacetylase activity|chitobiose amidohydrolase activity http://purl.obolibrary.org/obo/GO_0036311 GO:1901131 biolink:BiologicalProcess kanamycin metabolic process The chemical reactions and pathways involving kanamycin. go.json kanamycin metabolism http://purl.obolibrary.org/obo/GO_1901131 GO:0061367 biolink:BiologicalProcess behavioral response to acetic acid induced pain Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus. go.json http://purl.obolibrary.org/obo/GO_0061367 GO:0036312 biolink:MolecularActivity phosphatidylinositol 3-kinase regulatory subunit binding Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. go.json PI3K regulatory subunit binding|p85 binding http://purl.obolibrary.org/obo/GO_0036312 GO:0036313 biolink:MolecularActivity phosphatidylinositol 3-kinase catalytic subunit binding Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. go.json PI3K catalytic subunit binding|p110 binding http://purl.obolibrary.org/obo/GO_0036313 GO:0061368 biolink:BiologicalProcess behavioral response to formalin induced pain Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus. go.json http://purl.obolibrary.org/obo/GO_0061368 GO:0061369 biolink:BiologicalProcess negative regulation of testicular blood vessel morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle. go.json negative regulation of testicular vasculature morphogenesis http://purl.obolibrary.org/obo/GO_0061369 GO:0036314 biolink:BiologicalProcess response to sterol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. go.json http://purl.obolibrary.org/obo/GO_0036314 GO:0036315 biolink:BiologicalProcess cellular response to sterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. go.json http://purl.obolibrary.org/obo/GO_0036315 GO:0036316 biolink:BiologicalProcess SREBP-SCAP complex retention in endoplasmic reticulum Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER. go.json http://purl.obolibrary.org/obo/GO_0036316 GO:0036317 biolink:MolecularActivity tyrosyl-RNA phosphodiesterase activity Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. go.json VPg unlinkase activity|Y-pUpN PDE activity|unlinkase activity|uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0036317 GO:0036307 biolink:MolecularActivity 23S rRNA (adenine(2030)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA. EC:2.1.1.266|RHEA:43736 go.json http://purl.obolibrary.org/obo/GO_0036307 GO:1901138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901138 GO:0036308 biolink:MolecularActivity 16S rRNA (guanine(1516)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine. go.json http://purl.obolibrary.org/obo/GO_0036308 GO:1901139 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901139 GO:1901136 biolink:BiologicalProcess carbohydrate derivative catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. go.json carbohydrate derivative breakdown|carbohydrate derivative catabolism|carbohydrate derivative degradation http://purl.obolibrary.org/obo/GO_1901136 GO:0036309 biolink:BiologicalProcess protein localization to M-band Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere. go.json cellular protein localization to M-band|protein localization to M disc|protein localization to M line|protein localization to mesophragma http://purl.obolibrary.org/obo/GO_0036309 GO:1901137 biolink:BiologicalProcess carbohydrate derivative biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrate derivative. go.json carbohydrate derivative anabolism|carbohydrate derivative biosynthesis|carbohydrate derivative formation|carbohydrate derivative synthesis http://purl.obolibrary.org/obo/GO_1901137 GO:0061350 biolink:BiologicalProcess planar cell polarity pathway involved in cardiac muscle tissue morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue. go.json http://purl.obolibrary.org/obo/GO_0061350 GO:1901134 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901134 GO:1901135 biolink:BiologicalProcess carbohydrate derivative metabolic process The chemical reactions and pathways involving carbohydrate derivative. go.json carbohydrate derivative metabolism http://purl.obolibrary.org/obo/GO_1901135 goslim_agr|goslim_generic|goslim_mouse|prokaryote_subset GO:0061351 biolink:BiologicalProcess neural precursor cell proliferation The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. go.json http://purl.obolibrary.org/obo/GO_0061351 GO:1901132 biolink:BiologicalProcess kanamycin catabolic process The chemical reactions and pathways resulting in the breakdown of kanamycin. go.json kanamycin breakdown|kanamycin catabolism|kanamycin degradation http://purl.obolibrary.org/obo/GO_1901132 GO:0061352 biolink:BiologicalProcess cell chemotaxis involved in Malpighian tubule morphogenesis The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule. go.json http://purl.obolibrary.org/obo/GO_0061352 GO:0061353 biolink:BiologicalProcess obsolete BMP signaling pathway involved in Malpighian tubule cell chemotaxis OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule. go.json bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis True http://purl.obolibrary.org/obo/GO_0061353 GO:1901133 biolink:BiologicalProcess kanamycin biosynthetic process The chemical reactions and pathways resulting in the formation of kanamycin. go.json kanamycin anabolism|kanamycin biosynthesis|kanamycin formation|kanamycin synthesis http://purl.obolibrary.org/obo/GO_1901133 GO:1901141 biolink:BiologicalProcess regulation of lignin biosynthetic process Any process that modulates the frequency, rate or extent of lignin biosynthetic process. go.json regulation of lignin anabolism|regulation of lignin biosynthesis|regulation of lignin formation|regulation of lignin synthesis http://purl.obolibrary.org/obo/GO_1901141 GO:0061354 biolink:BiologicalProcess planar cell polarity pathway involved in pericardium morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium. go.json http://purl.obolibrary.org/obo/GO_0061354 GO:0036300 biolink:BiologicalProcess B cell receptor internalization A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell. go.json B cell receptor uptake of antigen|BCR endocytosis|BCR receptor internalization http://purl.obolibrary.org/obo/GO_0036300 GO:1901142 biolink:BiologicalProcess insulin metabolic process The chemical reactions and pathways involving insulin. go.json insulin metabolism http://purl.obolibrary.org/obo/GO_1901142 GO:0061355 biolink:BiologicalProcess Wnt protein secretion The controlled release of a Wnt protein from a cell. go.json http://purl.obolibrary.org/obo/GO_0061355 GO:0036301 biolink:BiologicalProcess macrophage colony-stimulating factor production The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json M-CSF production http://purl.obolibrary.org/obo/GO_0036301 gocheck_do_not_annotate GO:0061356 biolink:BiologicalProcess regulation of Wnt protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell. go.json http://purl.obolibrary.org/obo/GO_0061356 GO:0036302 biolink:BiologicalProcess atrioventricular canal development The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. go.json http://purl.obolibrary.org/obo/GO_0036302 GO:0061357 biolink:BiologicalProcess positive regulation of Wnt protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell. go.json http://purl.obolibrary.org/obo/GO_0061357 GO:1901140 biolink:BiologicalProcess p-coumaryl alcohol transport The directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 4-hydroxycinnamyl alcohol transport http://purl.obolibrary.org/obo/GO_1901140 GO:0061358 biolink:BiologicalProcess negative regulation of Wnt protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell. go.json http://purl.obolibrary.org/obo/GO_0061358 GO:0036303 biolink:BiologicalProcess lymph vessel morphogenesis The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. go.json http://purl.obolibrary.org/obo/GO_0036303 GO:0061359 biolink:BiologicalProcess regulation of Wnt signaling pathway by Wnt protein secretion Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell. go.json regulation of Wnt receptor signaling pathway by Wnt protein secretion|regulation of Wnt receptor signalling pathway by Wnt protein secretion|regulation of Wnt-activated signaling pathway by Wnt protein secretion http://purl.obolibrary.org/obo/GO_0061359 GO:0036304 biolink:BiologicalProcess umbilical cord morphogenesis The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. go.json http://purl.obolibrary.org/obo/GO_0036304 GO:0036305 biolink:BiologicalProcess ameloblast differentiation The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ. go.json http://purl.obolibrary.org/obo/GO_0036305 GO:0036306 biolink:BiologicalProcess embryonic heart tube elongation The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. go.json http://purl.obolibrary.org/obo/GO_0036306 GO:1901149 biolink:MolecularActivity salicylic acid binding Binding to salicylic acid. go.json salicylic acid receptor http://purl.obolibrary.org/obo/GO_1901149 GO:0061380 biolink:BiologicalProcess superior colliculus development The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain. go.json http://purl.obolibrary.org/obo/GO_0061380 GO:0061381 biolink:BiologicalProcess cell migration in diencephalon The orderly movement of a cell that will reside in the diencephalon. go.json http://purl.obolibrary.org/obo/GO_0061381 GO:1901147 biolink:BiologicalProcess mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1901147 GO:1901148 biolink:BiologicalProcess gene expression involved in extracellular matrix organization Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. go.json expression of extracellular matrix proteins|extracellular matrix protein production http://purl.obolibrary.org/obo/GO_1901148 GO:0061382 biolink:BiologicalProcess Malpighian tubule tip cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells. go.json http://purl.obolibrary.org/obo/GO_0061382 GO:1901145 biolink:BiologicalProcess mesenchymal cell apoptotic process involved in nephron morphogenesis Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1901145 GO:0061383 biolink:BiologicalProcess trabecula morphogenesis The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. go.json http://purl.obolibrary.org/obo/GO_0061383 GO:1901146 biolink:BiologicalProcess mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1901146 GO:0061384 biolink:BiologicalProcess heart trabecula morphogenesis The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. go.json http://purl.obolibrary.org/obo/GO_0061384 GO:1901143 biolink:BiologicalProcess insulin catabolic process The chemical reactions and pathways resulting in the breakdown of insulin. go.json insulin breakdown|insulin catabolism|insulin degradation http://purl.obolibrary.org/obo/GO_1901143 GO:0061385 biolink:BiologicalProcess fibroblast proliferation involved in heart morphogenesis The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0061385 GO:1901144 biolink:BiologicalProcess obsolete insulin biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of insulin. go.json insulin anabolism|insulin biosynthesis|insulin biosynthetic process|insulin formation|insulin synthesis True http://purl.obolibrary.org/obo/GO_1901144 GO:0061386 biolink:BiologicalProcess closure of optic fissure The closure of the temporary ventral gap in the optic cup that contributes to its shaping. go.json closure or choriod fissure http://purl.obolibrary.org/obo/GO_0061386 GO:1901152 biolink:BiologicalProcess vistamycin biosynthetic process The chemical reactions and pathways resulting in the formation of vistamycin. go.json ribostamycin anabolism|ribostamycin biosynthesis|ribostamycin biosynthetic process|ribostamycin formation|ribostamycin synthesis|vistamycin anabolism|vistamycin biosynthesis|vistamycin formation|vistamycin synthesis http://purl.obolibrary.org/obo/GO_1901152 GO:0061387 biolink:BiologicalProcess regulation of extent of cell growth Any process that modulates the extent of cell growth. go.json http://purl.obolibrary.org/obo/GO_0061387 GO:0061388 biolink:BiologicalProcess regulation of rate of cell growth Any process that modulates the rate of cell growth. go.json http://purl.obolibrary.org/obo/GO_0061388 GO:1901153 biolink:BiologicalProcess paromomycin metabolic process The chemical reactions and pathways involving paromomycin. go.json paromomycin metabolism http://purl.obolibrary.org/obo/GO_1901153 GO:1901150 biolink:BiologicalProcess vistamycin metabolic process The chemical reactions and pathways involving vistamycin. go.json ribostamycin metabolic process|ribostamycin metabolism|vistamycin metabolism http://purl.obolibrary.org/obo/GO_1901150 GO:0061389 biolink:BiologicalProcess regulation of direction of cell growth Any process that modulates the direction of cell growth. go.json http://purl.obolibrary.org/obo/GO_0061389 GO:1901151 biolink:BiologicalProcess vistamycin catabolic process The chemical reactions and pathways resulting in the breakdown of vistamycin. go.json ribostamycin breakdown|ribostamycin catabolic process|ribostamycin catabolism|ribostamycin degradation|vistamycin breakdown|vistamycin catabolism|vistamycin degradation http://purl.obolibrary.org/obo/GO_1901151 GO:1901158 biolink:BiologicalProcess neomycin biosynthetic process The chemical reactions and pathways resulting in the formation of neomycin. go.json neomycin anabolism|neomycin biosynthesis|neomycin formation|neomycin synthesis http://purl.obolibrary.org/obo/GO_1901158 GO:0061370 biolink:BiologicalProcess testosterone biosynthetic process The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5. go.json http://purl.obolibrary.org/obo/GO_0061370 GO:0061371 biolink:BiologicalProcess determination of heart left/right asymmetry Determination of the asymmetric location of the heart with respect to the left and right halves of the organism. go.json determination of cardiac left/right asymmetry http://purl.obolibrary.org/obo/GO_0061371 GO:1901159 biolink:BiologicalProcess xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate. go.json xylulose 5-phosphate anabolism|xylulose 5-phosphate biosynthesis|xylulose 5-phosphate formation|xylulose 5-phosphate synthesis http://purl.obolibrary.org/obo/GO_1901159 GO:0061372 biolink:BiologicalProcess obsolete activin receptor signaling pathway involved in heart jogging OBSOLETE. The series of molecular signals initiated by the binding of a member of the activin family to its receptor on the surface of a target cell, and contributing to the process of heart jogging. go.json activin receptor signalling pathway involved in heart jogging True http://purl.obolibrary.org/obo/GO_0061372 GO:1901156 biolink:BiologicalProcess neomycin metabolic process The chemical reactions and pathways involving neomycin. go.json neomycin metabolism http://purl.obolibrary.org/obo/GO_1901156 GO:1901157 biolink:BiologicalProcess neomycin catabolic process The chemical reactions and pathways resulting in the breakdown of neomycin. go.json neomycin breakdown|neomycin catabolism|neomycin degradation http://purl.obolibrary.org/obo/GO_1901157 GO:0061373 biolink:BiologicalProcess mammillary axonal complex development The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain. go.json http://purl.obolibrary.org/obo/GO_0061373 GO:1901154 biolink:BiologicalProcess paromomycin catabolic process The chemical reactions and pathways resulting in the breakdown of paromomycin. go.json paromomycin breakdown|paromomycin catabolism|paromomycin degradation http://purl.obolibrary.org/obo/GO_1901154 GO:0061374 biolink:BiologicalProcess mammillothalamic axonal tract development The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit. go.json http://purl.obolibrary.org/obo/GO_0061374 GO:0061375 biolink:BiologicalProcess mammillotectal axonal tract development The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus. go.json http://purl.obolibrary.org/obo/GO_0061375 GO:1901155 biolink:BiologicalProcess paromomycin biosynthetic process The chemical reactions and pathways resulting in the formation of paromomycin. go.json paromomycin anabolism|paromomycin biosynthesis|paromomycin formation|paromomycin synthesis http://purl.obolibrary.org/obo/GO_1901155 GO:1901163 biolink:BiologicalProcess regulation of trophoblast cell migration Any process that modulates the frequency, rate or extent of trophoblast cell migration. go.json http://purl.obolibrary.org/obo/GO_1901163 GO:0061376 biolink:BiologicalProcess mammillotegmental axonal tract development The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons. go.json http://purl.obolibrary.org/obo/GO_0061376 GO:0061377 biolink:BiologicalProcess mammary gland lobule development The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. go.json http://purl.obolibrary.org/obo/GO_0061377 GO:1901164 biolink:BiologicalProcess negative regulation of trophoblast cell migration Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. go.json down regulation of trophoblast cell migration|down-regulation of trophoblast cell migration|downregulation of trophoblast cell migration|inhibition of trophoblast cell migration http://purl.obolibrary.org/obo/GO_1901164 GO:1901161 biolink:BiologicalProcess primary amino compound catabolic process The chemical reactions and pathways resulting in the breakdown of primary amino compound. go.json primary amino compound breakdown|primary amino compound catabolism|primary amino compound degradation http://purl.obolibrary.org/obo/GO_1901161 GO:0061378 biolink:BiologicalProcess corpora quadrigemina development The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi. go.json http://purl.obolibrary.org/obo/GO_0061378 GO:1901162 biolink:BiologicalProcess primary amino compound biosynthetic process The chemical reactions and pathways resulting in the formation of primary amino compound. go.json primary amino compound anabolism|primary amino compound biosynthesis|primary amino compound formation|primary amino compound synthesis http://purl.obolibrary.org/obo/GO_1901162 GO:0061379 biolink:BiologicalProcess inferior colliculus development The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally. go.json http://purl.obolibrary.org/obo/GO_0061379 GO:1901160 biolink:BiologicalProcess primary amino compound metabolic process The chemical reactions and pathways involving primary amino compound. go.json primary amino compound metabolism http://purl.obolibrary.org/obo/GO_1901160 GO:0051911 biolink:MolecularActivity Methanosarcina-phenazine hydrogenase activity Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine. EC:1.12.98.3|MetaCyc:RXN-7733|RHEA:24436 go.json coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity|hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity|methanophenazine hydrogenase activity|methylviologen-reducing hydrogenase activity http://purl.obolibrary.org/obo/GO_0051911 GO:0051912 biolink:MolecularActivity CoB--CoM heterodisulfide reductase activity Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine. EC:1.8.98.1|MetaCyc:1.8.98.1-RXN|RHEA:18085 go.json CoB-CoM heterodisulfide reductase activity|coenzyme B--coenzyme M heterodisulfide reductase activity|coenzyme B:coenzyme M:methanophenazine oxidoreductase activity|coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity|heterodisulfide reductase activity|soluble heterodisulfide reductase activity http://purl.obolibrary.org/obo/GO_0051912 GO:0051910 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051910 GO:0051915 biolink:BiologicalProcess induction of synaptic plasticity by chemical substance The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require. go.json activation of synaptic plasticity by chemical substance|activation of synaptic plasticity by drug|induction of synaptic plasticity by drug http://purl.obolibrary.org/obo/GO_0051915 GO:0051916 biolink:MolecularActivity granulocyte colony-stimulating factor binding Binding to granulocyte colony-stimulating factor, G-CSF. go.json G-CSF binding|granulocyte colony stimulating factor binding http://purl.obolibrary.org/obo/GO_0051916 GO:0051913 biolink:BiologicalProcess regulation of synaptic plasticity by chemical substance The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require. go.json regulation of synaptic plasticity by drug http://purl.obolibrary.org/obo/GO_0051913 GO:0051914 biolink:BiologicalProcess positive regulation of synaptic plasticity by chemical substance The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require. go.json activation of synaptic plasticity by chemical substance|positive regulation of synaptic plasticity by drug|stimulation of synaptic plasticity by chemical substance|up regulation of synaptic plasticity by chemical substance|up-regulation of synaptic plasticity by chemical substance|upregulation of synaptic plasticity by chemical substance http://purl.obolibrary.org/obo/GO_0051914 GO:0051919 biolink:BiologicalProcess positive regulation of fibrinolysis Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. go.json activation of fibrinolysis|stimulation of fibrinolysis|up regulation of fibrinolysis|up-regulation of fibrinolysis|upregulation of fibrinolysis http://purl.obolibrary.org/obo/GO_0051919 GO:0120336 biolink:CellularComponent radial spoke head 1 The portion of the radial spoke 1 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme. go.json radial spokehead 1 http://purl.obolibrary.org/obo/GO_0120336 GO:0120337 biolink:CellularComponent radial spoke head 2 The portion of the radial spoke 2 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme. go.json radial spokehead 2 http://purl.obolibrary.org/obo/GO_0120337 GO:0120338 biolink:CellularComponent radial spoke head 3 The portion of the radial spoke 3 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme. go.json radial spokehead 3 http://purl.obolibrary.org/obo/GO_0120338 GO:0051917 biolink:BiologicalProcess regulation of fibrinolysis Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. go.json http://purl.obolibrary.org/obo/GO_0051917 GO:0120339 biolink:CellularComponent radial spoke base The short portion of the radial spoke that is directly anchored to the A microtubule of an axonemal microtubule doublet. go.json http://purl.obolibrary.org/obo/GO_0120339 GO:0051918 biolink:BiologicalProcess negative regulation of fibrinolysis Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. go.json down regulation of fibrinolysis|down-regulation of fibrinolysis|downregulation of fibrinolysis|inhibition of fibrinolysis http://purl.obolibrary.org/obo/GO_0051918 GO:2000184 biolink:BiologicalProcess positive regulation of progesterone biosynthetic process Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process. go.json positive regulation of progesterone anabolism|positive regulation of progesterone biosynthesis|positive regulation of progesterone formation|positive regulation of progesterone synthesis http://purl.obolibrary.org/obo/GO_2000184 GO:0120332 biolink:BiologicalProcess host-mediated regulation of oral microbiota composition The biological process involved in maintaining the steady-state number of cells within a population of free-living cells, such as the bacteria, in the mouth. go.json host-induced regulation of oral microbiota composition http://purl.obolibrary.org/obo/GO_0120332 GO:0120333 biolink:CellularComponent radial spoke 1 The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is most proximal to the base of the cilium. Radial spoke 1 (RS1), similarly to radial spoke 2, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS1 is connected to the tail of the inner dynein arm a/d. go.json RS1 http://purl.obolibrary.org/obo/GO_0120333 GO:2000185 biolink:BiologicalProcess regulation of phosphate transmembrane transport Any process that modulates the frequency, rate or extent of phosphate transmembrane transport. go.json regulation of phosphate membrane transport http://purl.obolibrary.org/obo/GO_2000185 GO:0120334 biolink:CellularComponent radial spoke 2 The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is immediately distal to radial spoke 1 (RS1). Radial spoke 2 (RS2), similarly to RS1, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS2 is connected to the tail of the inner dynein arm c. go.json RS2 http://purl.obolibrary.org/obo/GO_0120334 GO:2000186 biolink:BiologicalProcess negative regulation of phosphate transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport. go.json negative regulation of phosphate membrane transport http://purl.obolibrary.org/obo/GO_2000186 GO:0120335 biolink:CellularComponent radial spoke 3 Radial spoke 3 (RS3), when present, is the most distal of each group of radial spokes, whether grouped as triplets or doublets. RS3 has significantly different morphology and protein composition than RS1 and RS2 and also extends at a slant from the microtubule doublet, rather than perpendicularly like RS1 and RS2. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), RS3 is represented only as a stump attached to the A-microtubule lacking the rest of the stalk structure and entirely lacking the head structure. go.json RS3 http://purl.obolibrary.org/obo/GO_0120335 GO:2000187 biolink:BiologicalProcess positive regulation of phosphate transmembrane transport Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport. go.json positive regulation of phosphate membrane transport http://purl.obolibrary.org/obo/GO_2000187 GO:2000188 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000188 GO:2000189 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000189 GO:0120330 biolink:CellularComponent rixosome complex A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans. go.json http://purl.obolibrary.org/obo/GO_0120330 GO:0120331 biolink:BiologicalProcess endothelial tube formation The developmental process pertaining to the initial formation of an endothelial tube. go.json http://purl.obolibrary.org/obo/GO_0120331 GO:2000180 biolink:BiologicalProcess negative regulation of androgen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process. go.json negative regulation of androgen anabolism|negative regulation of androgen biosynthesis|negative regulation of androgen formation|negative regulation of androgen synthesis http://purl.obolibrary.org/obo/GO_2000180 GO:2000181 biolink:BiologicalProcess negative regulation of blood vessel morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000181 GO:2000182 biolink:BiologicalProcess regulation of progesterone biosynthetic process Any process that modulates the frequency, rate or extent of progesterone biosynthetic process. go.json regulation of progesterone anabolism|regulation of progesterone biosynthesis|regulation of progesterone formation|regulation of progesterone synthesis http://purl.obolibrary.org/obo/GO_2000182 GO:2000183 biolink:BiologicalProcess negative regulation of progesterone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process. go.json negative regulation of progesterone anabolism|negative regulation of progesterone biosynthesis|negative regulation of progesterone formation|negative regulation of progesterone synthesis http://purl.obolibrary.org/obo/GO_2000183 GO:0051922 biolink:MolecularActivity cholesterol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+. RHEA:52368 go.json http://purl.obolibrary.org/obo/GO_0051922 GO:0051923 biolink:BiologicalProcess sulfation The addition of a sulfate group to a molecule. go.json phase II metabolism|sulfonation|sulfur addition|sulphation|sulphur addition http://purl.obolibrary.org/obo/GO_0051923 GO:0051920 biolink:MolecularActivity peroxiredoxin activity Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. RHEA:10008|Reactome:R-HSA-1222431|Reactome:R-HSA-1222755|Reactome:R-HSA-1500804 go.json PRDX activity|Prx activity http://purl.obolibrary.org/obo/GO_0051920 GO:0051921 biolink:MolecularActivity adenosylcobyric acid synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate. EC:6.3.5.10|KEGG_REACTION:R05225|MetaCyc:R345-RXN|RHEA:23256 go.json 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity|Ado-cobyric acid synthase [glutamine hydrolyzing] activity|CobQ activity|adenosylcobyric acid synthase (glutamine-hydrolysing) activity|adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)|cobyric acid synthase activity http://purl.obolibrary.org/obo/GO_0051921 GO:0051926 biolink:BiologicalProcess negative regulation of calcium ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of calcium ion transport|down-regulation of calcium ion transport|downregulation of calcium ion transport|inhibition of calcium ion transport|negative regulation of calcium transport http://purl.obolibrary.org/obo/GO_0051926 GO:0051927 biolink:BiologicalProcess obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel. go.json down regulation of calcium ion transport via voltage gated calcium channel|down-regulation of calcium ion transport via voltage gated calcium channel|downregulation of calcium ion transport via voltage gated calcium channel|inhibition of calcium ion transport via voltage gated calcium channel|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of calcium transport via voltage gated calcium channel True http://purl.obolibrary.org/obo/GO_0051927 GO:0051924 biolink:BiologicalProcess regulation of calcium ion transport Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of calcium transport http://purl.obolibrary.org/obo/GO_0051924 GO:0051925 biolink:BiologicalProcess obsolete regulation of calcium ion transport via voltage-gated calcium channel activity OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel. go.json regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of calcium transport via voltage-gated calcium channel True http://purl.obolibrary.org/obo/GO_0051925 GO:0051928 biolink:BiologicalProcess positive regulation of calcium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of calcium ion transport|positive regulation of calcium transport|stimulation of calcium ion transport|up regulation of calcium ion transport|up-regulation of calcium ion transport|upregulation of calcium ion transport http://purl.obolibrary.org/obo/GO_0051928 GO:0051929 biolink:BiologicalProcess obsolete positive regulation of calcium ion transport via voltage-gated calcium channel activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels. go.json activation of calcium ion transport via voltage gated calcium channel|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of calcium transport via voltage gated calcium channel|stimulation of calcium ion transport via voltage gated calcium channel|up regulation of calcium ion transport via voltage gated calcium channel|up-regulation of calcium ion transport via voltage gated calcium channel|upregulation of calcium ion transport via voltage gated calcium channel True http://purl.obolibrary.org/obo/GO_0051929 GO:2000195 biolink:BiologicalProcess negative regulation of female gonad development Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. go.json negative regulation of ovarian development|negative regulation of ovary development http://purl.obolibrary.org/obo/GO_2000195 GO:0120343 biolink:CellularComponent radial spoke neck The radial spoke neck is a complex that connects the spoke stalk to the head. go.json http://purl.obolibrary.org/obo/GO_0120343 GO:2000196 biolink:BiologicalProcess positive regulation of female gonad development Any process that activates or increases the frequency, rate or extent of female gonad development. go.json positive regulation of ovarian development|positive regulation of ovary development http://purl.obolibrary.org/obo/GO_2000196 GO:2000197 biolink:BiologicalProcess regulation of ribonucleoprotein complex localization Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization. go.json regulation of RNP localization|regulation of cellular ribonucleoprotein complex localization|regulation of establishment and maintenance of ribonucleoprotein complex localization|regulation of ribonucleoprotein complex localisation http://purl.obolibrary.org/obo/GO_2000197 GO:2000198 biolink:BiologicalProcess negative regulation of ribonucleoprotein complex localization Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization. go.json negative regulation of RNP localization|negative regulation of cellular ribonucleoprotein complex localization|negative regulation of establishment and maintenance of ribonucleoprotein complex localization|negative regulation of ribonucleoprotein complex localisation http://purl.obolibrary.org/obo/GO_2000198 GO:2000199 biolink:BiologicalProcess positive regulation of ribonucleoprotein complex localization Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization. go.json positive regulation of RNP localization|positive regulation of cellular ribonucleoprotein complex localization|positive regulation of establishment and maintenance of ribonucleoprotein complex localization|positive regulation of ribonucleoprotein complex localisation http://purl.obolibrary.org/obo/GO_2000199 GO:0120340 biolink:CellularComponent radial spoke base 1 The short portion of the radial spoke 1 (RS1) that is directly anchored to the A microtubule of an axonemal microtubule doublet. go.json http://purl.obolibrary.org/obo/GO_0120340 GO:0120341 biolink:CellularComponent radial spoke base 2 The short portion of the radial spoke 2 (RS2) that is directly anchored to the A microtubule of an axonemal microtubule doublet. go.json http://purl.obolibrary.org/obo/GO_0120341 GO:0120342 biolink:CellularComponent radial spoke base 3 The short portion of the radial spoke 3 (RS3 )that is directly anchored to the A microtubule of an axonemal microtubule doublet. go.json http://purl.obolibrary.org/obo/GO_0120342 GO:2000190 biolink:BiologicalProcess obsolete negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor. go.json negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor True http://purl.obolibrary.org/obo/GO_2000190 GO:2000191 biolink:BiologicalProcess regulation of fatty acid transport Any process that modulates the frequency, rate or extent of fatty acid transport. go.json http://purl.obolibrary.org/obo/GO_2000191 GO:2000192 biolink:BiologicalProcess negative regulation of fatty acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport. go.json http://purl.obolibrary.org/obo/GO_2000192 GO:2000193 biolink:BiologicalProcess positive regulation of fatty acid transport Any process that activates or increases the frequency, rate or extent of fatty acid transport. go.json http://purl.obolibrary.org/obo/GO_2000193 GO:2000194 biolink:BiologicalProcess regulation of female gonad development Any process that modulates the frequency, rate or extent of female gonad development. go.json regulation of ovarian development|regulation of ovary development http://purl.obolibrary.org/obo/GO_2000194 GO:0051930 biolink:BiologicalProcess regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. go.json http://purl.obolibrary.org/obo/GO_0051930 GO:0051933 biolink:BiologicalProcess amino acid neurotransmitter reuptake The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. go.json amino acid neurotransmitter import into glial cell|amino acid neurotransmitter import into neuron|amino acid neurotransmitter recycling|amino acid uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051933 GO:0051934 biolink:BiologicalProcess catecholamine uptake involved in synaptic transmission The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. go.json catecholamine neurotransmitter import into glial cell|catecholamine neurotransmitter import into neuron|catecholamine neurotransmitter recycling|catecholamine neurotransmitter reuptake|catecholamine reuptake during transmission of nerve impulse|catecholamine uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051934 GO:0051931 biolink:BiologicalProcess regulation of sensory perception Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. go.json http://purl.obolibrary.org/obo/GO_0051931 GO:0051932 biolink:BiologicalProcess synaptic transmission, GABAergic The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json GABAergic synaptic transmission|synaptic transmission, GABA mediated|synaptic transmission, gamma-aminobutyric acid mediated|synaptic transmission, gamma-aminobutyric acid-ergic http://purl.obolibrary.org/obo/GO_0051932 GO:0051937 biolink:BiologicalProcess catecholamine transport The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. go.json http://purl.obolibrary.org/obo/GO_0051937 GO:0051938 biolink:BiologicalProcess L-glutamate import The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. go.json L-glutamate uptake http://purl.obolibrary.org/obo/GO_0051938 GO:0051935 biolink:BiologicalProcess glutamate reuptake The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. go.json L-glutamate reuptake|L-glutamate uptake during transmission of nerve impulse|L-glutamate uptake involved in synaptic transmission|glutamate import into glial cell|glutamate import into neuron|glutamate recycling|glutamate uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051935 GO:0051936 biolink:BiologicalProcess gamma-aminobutyric acid reuptake The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. go.json GABA import into glial cell|GABA import into neuron|GABA recycling|GABA reuptake|gamma-aminobutyric acid import into glial cell|gamma-aminobutyric acid import into neuron|gamma-aminobutyric acid recycling|gamma-aminobutyric acid uptake during transmission of nerve impulse|gamma-aminobutyric acid uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051936 GO:0051939 biolink:BiologicalProcess gamma-aminobutyric acid import The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. go.json 4-aminobutyrate import|GABA import|gamma-aminobutyrate import|gamma-aminobutyric acid uptake http://purl.obolibrary.org/obo/GO_0051939 GO:0051940 biolink:BiologicalProcess regulation of catecholamine uptake involved in synaptic transmission Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. go.json regulation of catecholamine neurotransmitter reuptake|regulation of catecholamine neurotransmitter uptake|regulation of catecholamine uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051940 GO:0051941 biolink:BiologicalProcess regulation of amino acid uptake involved in synaptic transmission Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. go.json regulation of amino acid neurotransmitter reuptake|regulation of amino acid neurotransmitter uptake|regulation of amino acid uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051941 GO:0051944 biolink:BiologicalProcess positive regulation of catecholamine uptake involved in synaptic transmission Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. go.json activation of catecholamine uptake during transmission of nerve impulse|positive regulation of catecholamine neurotransmitter reuptake|positive regulation of catecholamine neurotransmitter uptake|positive regulation of catecholamine uptake during transmission of nerve impulse|stimulation of catecholamine uptake during transmission of nerve impulse|up regulation of catecholamine uptake during transmission of nerve impulse|up-regulation of catecholamine uptake during transmission of nerve impulse|upregulation of catecholamine uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051944 GO:0051945 biolink:BiologicalProcess negative regulation of catecholamine uptake involved in synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. go.json down regulation of catecholamine uptake during transmission of nerve impulse|down-regulation of catecholamine uptake during transmission of nerve impulse|downregulation of catecholamine uptake during transmission of nerve impulse|inhibition of catecholamine uptake during transmission of nerve impulse|negative regulation of catecholamine neurotransmitter reuptake|negative regulation of catecholamine neurotransmitter uptake|negative regulation of catecholamine uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051945 GO:0051942 biolink:BiologicalProcess negative regulation of amino acid uptake involved in synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. go.json down regulation of amino acid uptake during transmission of nerve impulse|down-regulation of amino acid uptake during transmission of nerve impulse|downregulation of amino acid uptake during transmission of nerve impulse|inhibition of amino acid uptake during transmission of nerve impulse|negative regulation of amino acid neurotransmitter reuptake|negative regulation of amino acid neurotransmitter uptake|negative regulation of amino acid uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051942 GO:0051943 biolink:BiologicalProcess positive regulation of amino acid uptake involved in synaptic transmission Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. go.json activation of amino acid uptake during transmission of nerve impulse|positive regulation of amino acid neurotransmitter reuptake|positive regulation of amino acid neurotransmitter uptake|stimulation of amino acid uptake during transmission of nerve impulse|up regulation of amino acid uptake during transmission of nerve impulse|up-regulation of amino acid uptake during transmission of nerve impulse|upregulation of amino acid uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051943 GO:0051948 biolink:BiologicalProcess negative regulation of glutamate uptake involved in transmission of nerve impulse Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. go.json down regulation of glutamate uptake during transmission of nerve impulse|down-regulation of glutamate uptake during transmission of nerve impulse|downregulation of glutamate uptake during transmission of nerve impulse|inhibition of glutamate uptake during transmission of nerve impulse|negative regulation of glutamate reuptake|negative regulation of glutamate uptake during transmission of nerve impulse|negative regulation of glutamate uptake involved in conduction of nerve impulse http://purl.obolibrary.org/obo/GO_0051948 GO:0051949 biolink:BiologicalProcess negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. go.json down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse|negative regulation of 4-aminobutyrate reuptake|negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse|negative regulation of GABA reuptake|negative regulation of GABA uptake during transmission of nerve impulse|negative regulation of gamma-aminobutyric acid reuptake|negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse http://purl.obolibrary.org/obo/GO_0051949 GO:0051946 biolink:BiologicalProcess regulation of glutamate uptake involved in transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. go.json regulation of L-glutamate reuptake|regulation of L-glutamate uptake during transmission of nerve impulse|regulation of glutamate reuptake|regulation of glutamate uptake during transmission of nerve impulse|regulation of glutamate uptake involved in conduction of nerve impulse http://purl.obolibrary.org/obo/GO_0051946 GO:0051947 biolink:BiologicalProcess regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. go.json regulation of 4-aminobutyrate reuptake|regulation of 4-aminobutyrate uptake during transmission of nerve impulse|regulation of GABA reuptake|regulation of GABA uptake during transmission of nerve impulse|regulation of gamma-aminobutyric acid reuptake|regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse http://purl.obolibrary.org/obo/GO_0051947 GO:0051951 biolink:BiologicalProcess positive regulation of glutamate uptake involved in transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. go.json activation of glutamate uptake during transmission of nerve impulse|positive regulation of glutamate reuptake|positive regulation of glutamate uptake during transmission of nerve impulse|positive regulation of glutamate uptake involved in conduction of nerve impulse|stimulation of glutamate uptake during transmission of nerve impulse|up regulation of glutamate uptake during transmission of nerve impulse|up-regulation of glutamate uptake during transmission of nerve impulse|upregulation of glutamate uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051951 GO:0051952 biolink:BiologicalProcess regulation of amine transport Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051952 GO:0051950 biolink:BiologicalProcess positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. go.json activation of gamma-aminobutyric acid uptake during transmission of nerve impulse|positive regulation of 4-aminobutyrate reuptake|positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse|positive regulation of GABA reuptake|positive regulation of GABA uptake during transmission of nerve impulse|positive regulation of gamma-aminobutyric acid reuptake|positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse|stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse|upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051950 GO:0051955 biolink:BiologicalProcess regulation of amino acid transport Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051955 GO:0051956 biolink:BiologicalProcess negative regulation of amino acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of amino acid transport|down-regulation of amino acid transport|downregulation of amino acid transport|inhibition of amino acid transport|negative regulation of amino acid transmembrane transport http://purl.obolibrary.org/obo/GO_0051956 GO:0051953 biolink:BiologicalProcess negative regulation of amine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of amine transport|down-regulation of amine transport|downregulation of amine transport|inhibition of amine transport http://purl.obolibrary.org/obo/GO_0051953 GO:0051954 biolink:BiologicalProcess positive regulation of amine transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of amine transport|stimulation of amine transport|up regulation of amine transport|up-regulation of amine transport|upregulation of amine transport http://purl.obolibrary.org/obo/GO_0051954 GO:0051959 biolink:MolecularActivity dynein light intermediate chain binding Binding to a light intermediate chain of the dynein complex. go.json http://purl.obolibrary.org/obo/GO_0051959 GO:2000148 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000148 GO:2000149 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000149 GO:0051957 biolink:BiologicalProcess positive regulation of amino acid transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of amino acid transport|positive regulation of amino acid transmembrane transport|stimulation of amino acid transport|up regulation of amino acid transport|up-regulation of amino acid transport|upregulation of amino acid transport http://purl.obolibrary.org/obo/GO_0051957 GO:0051958 biolink:BiologicalProcess methotrexate transport The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. go.json http://purl.obolibrary.org/obo/GO_0051958 GO:0036398 biolink:CellularComponent TCR signalosome A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. go.json LAT signalosome|linker for activation of T cells signalosome http://purl.obolibrary.org/obo/GO_0036398 GO:2000140 biolink:BiologicalProcess negative regulation of octopamine signaling pathway involved in response to food Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food. go.json negative regulation of octopamine signalling pathway involved in response to food http://purl.obolibrary.org/obo/GO_2000140 GO:0036399 biolink:BiologicalProcess TCR signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome. go.json LAT signalosome assembly|linker for activation of T cells signalosome assembly http://purl.obolibrary.org/obo/GO_0036399 GO:2000141 biolink:BiologicalProcess positive regulation of octopamine signaling pathway involved in response to food Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food. go.json positive regulation of octopamine signalling pathway involved in response to food http://purl.obolibrary.org/obo/GO_2000141 GO:2000142 biolink:BiologicalProcess regulation of DNA-templated transcription initiation Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. go.json regulation of DNA-dependent transcription, initiation|regulation of DNA-templated transcription, initiation|regulation of initiation of DNA-dependent transcription|regulation of transcription initiation, DNA-dependent http://purl.obolibrary.org/obo/GO_2000142 GO:2000143 biolink:BiologicalProcess negative regulation of DNA-templated transcription initiation Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. go.json negative regulation of DNA-dependent transcription, initiation|negative regulation of DNA-templated transcription, initiation|negative regulation of initiation of DNA-dependent transcription|negative regulation of transcription initiation, DNA-dependent http://purl.obolibrary.org/obo/GO_2000143 GO:2000144 biolink:BiologicalProcess positive regulation of DNA-templated transcription initiation Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. go.json positive regulation of DNA-dependent transcription, initiation|positive regulation of DNA-templated transcription, initiation|positive regulation of initiation of DNA-dependent transcription|positive regulation of transcription initiation, DNA-dependent|transactivation|transcriptional transactivation http://purl.obolibrary.org/obo/GO_2000144 GO:2000145 biolink:BiologicalProcess regulation of cell motility Any process that modulates the frequency, rate or extent of cell motility. go.json regulation of cell locomotion|regulation of cell movement|regulation of movement of a cell http://purl.obolibrary.org/obo/GO_2000145 GO:2000146 biolink:BiologicalProcess negative regulation of cell motility Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. go.json negative regulation of cell locomotion|negative regulation of cell movement|negative regulation of movement of a cell http://purl.obolibrary.org/obo/GO_2000146 GO:2000147 biolink:BiologicalProcess positive regulation of cell motility Any process that activates or increases the frequency, rate or extent of cell motility. go.json positive regulation of cell locomotion|positive regulation of cell movement|positive regulation of movement of a cell http://purl.obolibrary.org/obo/GO_2000147 GO:0036390 biolink:BiologicalProcess pre-replicative complex assembly involved in bacterial-type DNA replication The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. go.json bacterial pre-RC assembly|bacterial pre-replicative complex assembly http://purl.obolibrary.org/obo/GO_0036390 GO:0036391 biolink:CellularComponent medial cortex septin ring A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. go.json http://purl.obolibrary.org/obo/GO_0036391 GO:0036392 biolink:BiologicalProcess chemokine (C-C motif) ligand 20 production The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json C-C motif chemokine 20 production|CCL-20 production|CCL20 production http://purl.obolibrary.org/obo/GO_0036392 gocheck_do_not_annotate GO:0036393 biolink:MolecularActivity thiocyanate peroxidase activity Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate. go.json lactoperoxidase activity http://purl.obolibrary.org/obo/GO_0036393 GO:0036394 biolink:BiologicalProcess amylase secretion The controlled release of amylase from a cell. go.json amylase release http://purl.obolibrary.org/obo/GO_0036394 GO:0036395 biolink:BiologicalProcess pancreatic amylase secretion The controlled release of amylase from a cell of the pancreas. go.json http://purl.obolibrary.org/obo/GO_0036395 GO:0036396 biolink:CellularComponent RNA N6-methyladenosine methyltransferase complex A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). go.json METTL3-METTL14-WTAP methyltransferase complex|MIS complex|Mum2, Ime4, and Slz1 complex|WMM complex|m(6)A writer complex|m6A methyltransferase complex http://purl.obolibrary.org/obo/GO_0036396 GO:0036397 biolink:MolecularActivity formate dehydrogenase (quinone) activity Catalysis of the reaction: formate + a quinone = CO2 + a quinol. EC:1.17.5.3|KEGG_REACTION:R09494|MetaCyc:FORMATEDEHYDROG-RXN|RHEA:48592 go.json Fdh-N activity|formate dehydrogenase-N activity|formate:quinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0036397 GO:0051962 biolink:BiologicalProcess positive regulation of nervous system development Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. go.json activation of nervous system development|stimulation of nervous system development|up regulation of nervous system development|up-regulation of nervous system development|upregulation of nervous system development http://purl.obolibrary.org/obo/GO_0051962 GO:0051963 biolink:BiologicalProcess regulation of synapse assembly Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. go.json regulation of synapse biogenesis|regulation of synaptogenesis http://purl.obolibrary.org/obo/GO_0051963 goslim_synapse GO:0051960 biolink:BiologicalProcess regulation of nervous system development Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. go.json http://purl.obolibrary.org/obo/GO_0051960 GO:0051961 biolink:BiologicalProcess negative regulation of nervous system development Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. go.json down regulation of nervous system development|down-regulation of nervous system development|downregulation of nervous system development|inhibition of nervous system development http://purl.obolibrary.org/obo/GO_0051961 GO:0051966 biolink:BiologicalProcess regulation of synaptic transmission, glutamatergic Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. go.json http://purl.obolibrary.org/obo/GO_0051966 GO:0051967 biolink:BiologicalProcess negative regulation of synaptic transmission, glutamatergic Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. go.json down regulation of synaptic transmission, glutamatergic|down-regulation of synaptic transmission, glutamatergic|downregulation of synaptic transmission, glutamatergic|inhibition of synaptic transmission, glutamatergic http://purl.obolibrary.org/obo/GO_0051967 GO:0051964 biolink:BiologicalProcess negative regulation of synapse assembly Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. go.json down regulation of synapse assembly|down-regulation of synapse assembly|downregulation of synapse assembly|inhibition of synapse assembly|negative regulation of synapse biogenesis|negative regulation of synaptogenesis http://purl.obolibrary.org/obo/GO_0051964 GO:0051965 biolink:BiologicalProcess positive regulation of synapse assembly Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. go.json activation of synapse assembly|positive regulation of synapse biogenesis|positive regulation of synaptogenesis|stimulation of synapse assembly|up regulation of synapse assembly|up-regulation of synapse assembly|upregulation of synapse assembly http://purl.obolibrary.org/obo/GO_0051965 GO:2000159 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in heart morphogenesis Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000159 GO:0120307 biolink:CellularComponent Hechtian strand An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely. Wikipedia:Hechtian_strand go.json http://purl.obolibrary.org/obo/GO_0120307 GO:0120308 biolink:BiologicalProcess axonemal outer doublet assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule. go.json axonemal outer doublet biogenesis|axonemal outer doublet formation|axonemal outer doublet morphogenesis|axoneme outer doublet assembly|outer doublet assembly|outer-doublet microtubule assembly http://purl.obolibrary.org/obo/GO_0120308 GO:0051968 biolink:BiologicalProcess positive regulation of synaptic transmission, glutamatergic Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. go.json activation of synaptic transmission, glutamatergic|stimulation of synaptic transmission, glutamatergic|up regulation of synaptic transmission, glutamatergic|up-regulation of synaptic transmission, glutamatergic|upregulation of synaptic transmission, glutamatergic http://purl.obolibrary.org/obo/GO_0051968 GO:0120309 biolink:BiologicalProcess cilium attachment to cell body A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species. go.json cilial attachment to cell body|ciliary attachment to cell body|flagellar attachment to cell body|flagellum attachment to cell body http://purl.obolibrary.org/obo/GO_0120309 GO:0051969 biolink:BiologicalProcess regulation of transmission of nerve impulse Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. go.json regulation of conduction of nerve impulse http://purl.obolibrary.org/obo/GO_0051969 GO:0120303 biolink:BiologicalProcess visually-mediated background adaptation Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells. go.json http://purl.obolibrary.org/obo/GO_0120303 GO:0120304 biolink:BiologicalProcess integument-mediated background adaptation Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument. go.json http://purl.obolibrary.org/obo/GO_0120304 GO:0120305 biolink:BiologicalProcess regulation of pigmentation Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. go.json http://purl.obolibrary.org/obo/GO_0120305 GO:0120306 biolink:BiologicalProcess cellular response to actin cytoskeletal stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton. go.json cellular response to actin cytoskeleton stress|cellular response to latrunculin A|cellular response to latrunculin B|response to latrunculin A|response to latrunculin B http://purl.obolibrary.org/obo/GO_0120306 GO:0036387 biolink:CellularComponent pre-replicative complex A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. go.json pre-RC|pre-replication complex http://purl.obolibrary.org/obo/GO_0036387 GO:2000151 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000151 GO:0120300 biolink:MolecularActivity peptide lactyltransferase activity Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein]. RHEA:61996 go.json http://purl.obolibrary.org/obo/GO_0120300 GO:0036388 biolink:BiologicalProcess pre-replicative complex assembly The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. go.json pre-RC assembly|pre-replication complex assembly http://purl.obolibrary.org/obo/GO_0036388 GO:2000152 biolink:BiologicalProcess regulation of ubiquitin-specific protease activity Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity. go.json regulation of UBP|regulation of UCH2|regulation of deubiquitinase activity http://purl.obolibrary.org/obo/GO_2000152 gocheck_do_not_annotate GO:0036389 biolink:CellularComponent bacterial pre-replicative complex A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. go.json bacterial pre-RC http://purl.obolibrary.org/obo/GO_0036389 GO:2000153 biolink:BiologicalProcess obsolete regulation of flagellar cell motility OBSOLETE. Any process that modulates the frequency, rate or extent of flagellar cell motility. go.json regulation of flagellar cell motility True http://purl.obolibrary.org/obo/GO_2000153 GO:0120301 biolink:MolecularActivity histone lactyltransferase activity Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone]. go.json http://purl.obolibrary.org/obo/GO_0120301 GO:2000154 biolink:BiologicalProcess obsolete negative regulation of flagellar cell motility OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility. go.json negative regulation of flagellar cell motility True http://purl.obolibrary.org/obo/GO_2000154 GO:0120302 biolink:BiologicalProcess background adaptation Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity. go.json http://purl.obolibrary.org/obo/GO_0120302 GO:2000155 biolink:BiologicalProcess positive regulation of cilium-dependent cell motility Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. go.json positive regulation of ciliary cell motility http://purl.obolibrary.org/obo/GO_2000155 GO:2000156 biolink:BiologicalProcess regulation of retrograde vesicle-mediated transport, Golgi to ER Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER. go.json regulation of cis-Golgi to rough ER transport|regulation of cis-Golgi to rough ER vesicle-mediated transport|regulation of cis-Golgi to rough endoplasmic reticulum transport|regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport|regulation of retrograde (Golgi to ER) transport|regulation of retrograde transport, Golgi to ER|regulation of retrograde transport, Golgi to endoplasmic reticulum|regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum http://purl.obolibrary.org/obo/GO_2000156 GO:2000157 biolink:BiologicalProcess negative regulation of ubiquitin-specific protease activity Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity. go.json negative regulation of UBP|negative regulation of UCH2|negative regulation of deubiquitinase activity|negative regulation of ubiquitin hydrolase activity http://purl.obolibrary.org/obo/GO_2000157 gocheck_do_not_annotate GO:2000158 biolink:BiologicalProcess positive regulation of ubiquitin-specific protease activity Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity. go.json positive regulation of UBP|positive regulation of UCH2|positive regulation of deubiquitinase activity|positive regulation of ubiquitin hydrolase activity http://purl.obolibrary.org/obo/GO_2000158 gocheck_do_not_annotate GO:0036380 biolink:MolecularActivity UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. EC:2.7.8.33|KEGG_REACTION:R08856|MetaCyc:GLCNACPTRANS-RXN|RHEA:28090 go.json GlcNAc-P-P-Und synthase activity|UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity|UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity|UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity|UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity http://purl.obolibrary.org/obo/GO_0036380 GO:0036381 biolink:MolecularActivity pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate. EC:4.3.3.6|KEGG_REACTION:R10089|MetaCyc:RXN-11322|RHEA:31507 go.json PdxST activity|pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity http://purl.obolibrary.org/obo/GO_0036381 GO:0036382 biolink:MolecularActivity flavin reductase (NADH) activity Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH. EC:1.5.1.36|KEGG_REACTION:R09662|MetaCyc:RXN-12446|RHEA:31303 go.json http://purl.obolibrary.org/obo/GO_0036382 GO:0036383 biolink:MolecularActivity 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O. EC:1.14.14.12|KEGG_REACTION:R09819|MetaCyc:RXN-12717|RHEA:31731 go.json http://purl.obolibrary.org/obo/GO_0036383 GO:0036384 biolink:MolecularActivity CDP phosphatase activity Catalysis of the reaction: CDP + H2O = CMP + phosphate. RHEA:64880 go.json CDP diphosphatase activity|CDPase activity|cytidine diphosphatase activity|cytidine-diphosphatase activity http://purl.obolibrary.org/obo/GO_0036384 GO:0036385 biolink:BiologicalProcess obsolete nucleoid DNA packaging OBSOLETE. Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid. go.json True http://purl.obolibrary.org/obo/GO_0036385 GO:2000150 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000150 GO:0036386 biolink:BiologicalProcess bacterial nucleoid packaging A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling. go.json bacterial nucleoid DNA packaging|chromosomal compaction|nucleoid compaction|prokaryotic DNA condensation http://purl.obolibrary.org/obo/GO_0036386 prokaryote_subset GO:0051973 biolink:BiologicalProcess positive regulation of telomerase activity Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). go.json activation of telomerase activity|stimulation of telomerase activity|telomerase activator|up regulation of telomerase activity|up-regulation of telomerase activity|upregulation of telomerase activity http://purl.obolibrary.org/obo/GO_0051973 gocheck_do_not_annotate GO:0051974 biolink:BiologicalProcess negative regulation of telomerase activity Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). go.json down regulation of telomerase activity|down-regulation of telomerase activity|downregulation of telomerase activity|inhibition of telomerase activity|telomerase inhibitor http://purl.obolibrary.org/obo/GO_0051974 gocheck_do_not_annotate GO:0051971 biolink:BiologicalProcess positive regulation of transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. go.json activation of transmission of nerve impulse|positive regulation of conduction of nerve impulse|stimulation of transmission of nerve impulse|up regulation of transmission of nerve impulse|up-regulation of transmission of nerve impulse|upregulation of transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0051971 GO:0051972 biolink:BiologicalProcess regulation of telomerase activity Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. go.json telomerase regulator http://purl.obolibrary.org/obo/GO_0051972 gocheck_do_not_annotate GO:0051977 biolink:BiologicalProcess lysophospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. go.json http://purl.obolibrary.org/obo/GO_0051977 GO:0051978 biolink:MolecularActivity lysophospholipid:sodium symporter activity Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. go.json lysophospholipid transporter activity http://purl.obolibrary.org/obo/GO_0051978 GO:0051975 biolink:BiologicalProcess lysine biosynthetic process via alpha-aminoadipate and saccharopine The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine. MetaCyc:LYSINE-AMINOAD-PWY go.json lysine biosynthesis via aminoadipic acid and saccharopine|lysine biosynthetic process via aminoadipic acid and saccharopine http://purl.obolibrary.org/obo/GO_0051975 GO:0051976 biolink:BiologicalProcess lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine. MetaCyc:PWY-3081 go.json lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate|lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate http://purl.obolibrary.org/obo/GO_0051976 GO:0120318 biolink:BiologicalProcess olfactory sociosexual communication The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system. go.json http://purl.obolibrary.org/obo/GO_0120318 GO:0120319 biolink:MolecularActivity long-chain fatty acid omega-1 hydroxylase activity Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. RHEA:60936 go.json cytochrome P450 fatty acid omega-1 hydroxylase activity http://purl.obolibrary.org/obo/GO_0120319 GO:0051979 biolink:BiologicalProcess alginic acid acetylation The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate. go.json alginate acetylation http://purl.obolibrary.org/obo/GO_0051979 GO:0120314 biolink:BiologicalProcess negative regulation of oocyte karyosome formation Any process that stops, prevents, or reduces the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. go.json http://purl.obolibrary.org/obo/GO_0120314 GO:0120315 biolink:BiologicalProcess positive regulation of oocyte karyosome formation Any process that activates or increases the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. go.json http://purl.obolibrary.org/obo/GO_0120315 GO:0120316 biolink:BiologicalProcess sperm flagellum assembly The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium). go.json http://purl.obolibrary.org/obo/GO_0120316 GO:0120317 biolink:BiologicalProcess sperm mitochondrial sheath assembly The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. go.json http://purl.obolibrary.org/obo/GO_0120317 GO:0036376 biolink:BiologicalProcess sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json sodium export|sodium ion export|sodium ion export from cell http://purl.obolibrary.org/obo/GO_0036376 GO:0120310 biolink:BiologicalProcess amastigogenesis The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites. go.json http://purl.obolibrary.org/obo/GO_0120310 GO:2000162 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000162 GO:0036377 biolink:BiologicalProcess arbuscular mycorrhizal association A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil. go.json arbuscular mycorrhizae formation|arbuscular mycorrhizal symbiosis|arbuscular mycorrhizas formation http://purl.obolibrary.org/obo/GO_0036377 GO:2000163 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in outflow tract morphogenesis Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000163 GO:0061300 biolink:BiologicalProcess cerebellum vasculature development The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061300 GO:0120311 biolink:BiologicalProcess ciliary pro-basal body maturation A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium. go.json flagellar pro-basal body maturation|flagellar probasal body maturation|pro-basal body maturation http://purl.obolibrary.org/obo/GO_0120311 GO:0061301 biolink:BiologicalProcess cerebellum vasculature morphogenesis The process in which the vasculature of the cerebellum is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061301 GO:0036378 biolink:BiologicalProcess calcitriol biosynthetic process from calciol Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. go.json 1alpha,25(OH)2D3 biosynthesis|1alpha,25-dihydroxycholecalciferol biosynthesis|1alpha,25-dihydroxyvitamin D3 biosynthesis|calcitriol biosynthesis from calciol|vitamin D3 activation http://purl.obolibrary.org/obo/GO_0036378 GO:0120312 biolink:BiologicalProcess ciliary basal body segregation The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites. go.json ciliary basal body separation|microtubule basal body segregation|microtubule basal body separation http://purl.obolibrary.org/obo/GO_0120312 GO:2000164 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000164 GO:0120313 biolink:BiologicalProcess regulation of oocyte karyosome formation Any process that modulates the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. go.json http://purl.obolibrary.org/obo/GO_0120313 GO:0061302 biolink:BiologicalProcess smooth muscle cell-matrix adhesion The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0061302 GO:2000165 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in pericardium morphogenesis Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000165 GO:0036379 biolink:CellularComponent myofilament Any of the smallest contractile units of a myofibril (striated muscle fiber). go.json striated muscle filament http://purl.obolibrary.org/obo/GO_0036379 GO:2000166 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000166 GO:0061303 biolink:BiologicalProcess cornea development in camera-type eye The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. go.json http://purl.obolibrary.org/obo/GO_0061303 GO:2000167 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in neural tube closure Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure. go.json http://purl.obolibrary.org/obo/GO_2000167 GO:0061304 biolink:BiologicalProcess retinal blood vessel morphogenesis The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061304 GO:0061305 biolink:BiologicalProcess maintenance of bipolar cell polarity regulating cell shape The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell. go.json http://purl.obolibrary.org/obo/GO_0061305 GO:2000168 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in neural tube closure Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure. go.json http://purl.obolibrary.org/obo/GO_2000168 GO:0061306 biolink:BiologicalProcess obsolete DNA strand renaturation involved in double-strand break repair OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair. go.json True http://purl.obolibrary.org/obo/GO_0061306 GO:2000169 biolink:BiologicalProcess regulation of peptidyl-cysteine S-nitrosylation Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation. go.json http://purl.obolibrary.org/obo/GO_2000169 GO:0061307 biolink:BiologicalProcess cardiac neural crest cell differentiation involved in heart development The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. go.json http://purl.obolibrary.org/obo/GO_0061307 GO:0061308 biolink:BiologicalProcess cardiac neural crest cell development involved in heart development The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. go.json http://purl.obolibrary.org/obo/GO_0061308 GO:0061309 biolink:BiologicalProcess cardiac neural crest cell development involved in outflow tract morphogenesis The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. go.json http://purl.obolibrary.org/obo/GO_0061309 GO:0036370 biolink:MolecularActivity D-alanyl carrier activity Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG). go.json D-alanyl carrier protein http://purl.obolibrary.org/obo/GO_0036370 GO:0036371 biolink:BiologicalProcess protein localization to T-tubule A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. go.json protein localisation to T-tubule|protein localization to T tubule|protein localization to transverse tubule http://purl.obolibrary.org/obo/GO_0036371 GO:0036372 biolink:BiologicalProcess opsin transport The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. go.json ciliary transport of opsin http://purl.obolibrary.org/obo/GO_0036372 GO:0051970 biolink:BiologicalProcess negative regulation of transmission of nerve impulse Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. go.json down regulation of transmission of nerve impulse|down-regulation of transmission of nerve impulse|downregulation of transmission of nerve impulse|inhibition of transmission of nerve impulse|negative regulation of conduction of nerve impulse http://purl.obolibrary.org/obo/GO_0051970 GO:0036373 biolink:MolecularActivity L-fucose mutarotase activity Catalysis of the reaction: alpha-L-fucose = beta-L-fucose. EC:5.1.3.29|MetaCyc:RXN0-5298|RHEA:25580 go.json alpha-L-fucose 1-epimerase activity|fucose 1-epimerase activity|type-2 mutarotase activity http://purl.obolibrary.org/obo/GO_0036373 GO:0036374 biolink:MolecularActivity glutathione hydrolase activity Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. EC:3.4.19.13|KEGG_REACTION:R00494|MetaCyc:RXN-12618|RHEA:28807|Reactome:R-HSA-1222712|Reactome:R-HSA-266046|Reactome:R-HSA-5433072|Reactome:R-HSA-5602984|Reactome:R-HSA-8943279|Reactome:R-HSA-9026757|Reactome:R-HSA-9026907|Reactome:R-HSA-9026912|Reactome:R-HSA-9026916|Reactome:R-HSA-9026927|Reactome:R-HSA-9035966|Reactome:R-HSA-9753634 go.json gamma-glutamyltranspeptidase activity|glutathionase activity http://purl.obolibrary.org/obo/GO_0036374 GO:2000160 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in heart morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000160 GO:2000161 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000161 GO:0036375 biolink:CellularComponent Kibra-Ex-Mer complex An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2. go.json KEM complex|Kbr, Ex and Mer complex http://purl.obolibrary.org/obo/GO_0036375 GO:0051984 biolink:BiologicalProcess positive regulation of chromosome segregation Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. go.json activation of chromosome segregation|stimulation of chromosome segregation|up regulation of chromosome segregation|up-regulation of chromosome segregation|upregulation of chromosome segregation http://purl.obolibrary.org/obo/GO_0051984 GO:0051985 biolink:BiologicalProcess negative regulation of chromosome segregation Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. go.json down regulation of chromosome segregation|down-regulation of chromosome segregation|downregulation of chromosome segregation|inhibition of chromosome segregation http://purl.obolibrary.org/obo/GO_0051985 GO:0051982 biolink:MolecularActivity copper-nicotianamine transmembrane transporter activity Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other. go.json Cu-NA chelate transporter activity http://purl.obolibrary.org/obo/GO_0051982 GO:0051983 biolink:BiologicalProcess regulation of chromosome segregation Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. go.json http://purl.obolibrary.org/obo/GO_0051983 GO:0051988 biolink:BiologicalProcess regulation of attachment of spindle microtubules to kinetochore Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. go.json regulation of kinetochore-microtubule attachment http://purl.obolibrary.org/obo/GO_0051988 GO:0051989 biolink:MolecularActivity coproporphyrinogen dehydrogenase activity Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine. EC:1.3.98.3|MetaCyc:HEMN-RXN|RHEA:15425 go.json HemN|coproporphyrinogen III oxidase activity|coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)|oxygen-independent coproporphyrinogen-III oxidase activity|radical SAM enzyme activity http://purl.obolibrary.org/obo/GO_0051989 GO:0051986 biolink:BiologicalProcess negative regulation of attachment of spindle microtubules to kinetochore Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. go.json down regulation of attachment of spindle microtubules to kinetochore|down-regulation of attachment of spindle microtubules to kinetochore|downregulation of attachment of spindle microtubules to kinetochore|inhibition of attachment of spindle microtubules to kinetochore http://purl.obolibrary.org/obo/GO_0051986 GO:0051987 biolink:BiologicalProcess positive regulation of attachment of spindle microtubules to kinetochore Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. go.json activation of attachment of spindle microtubules to kinetochore|stimulation of attachment of spindle microtubules to kinetochore|up regulation of attachment of spindle microtubules to kinetochore|up-regulation of attachment of spindle microtubules to kinetochore|upregulation of attachment of spindle microtubules to kinetochore http://purl.obolibrary.org/obo/GO_0051987 GO:0120329 biolink:BiologicalProcess protein localization to centriolar satellite A process in which a protein is transported to, or maintained in, a location within a centriolar satellite. go.json protein localisation to centriolar satellite http://purl.obolibrary.org/obo/GO_0120329 GO:0120325 biolink:MolecularActivity NuRD complex binding Binding to a NuRD complex. go.json http://purl.obolibrary.org/obo/GO_0120325 GO:0120326 biolink:BiologicalProcess appressorium-mediated entry into host Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json appressorium-mediated host invasion|appressorium-mediated host penetration|appressorium-mediated invasion into host|appressorium-mediated penetration into host http://purl.obolibrary.org/obo/GO_0120326 GO:0120327 biolink:CellularComponent telopode A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions. go.json http://purl.obolibrary.org/obo/GO_0120327 GO:0120328 biolink:MolecularActivity ATP-dependent DNA (cytosine-5-)-methyltransferase activity Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis. RHEA:68984 go.json http://purl.obolibrary.org/obo/GO_0120328 GO:0036365 biolink:BiologicalProcess transforming growth factor beta2 activation The release of transforming growth factor beta 2 (TGF-beta2) from its latent state. go.json TGF-beta 2 activation|TGFB2 activation|TGFbeta 2 activation http://purl.obolibrary.org/obo/GO_0036365 GO:2000173 biolink:BiologicalProcess negative regulation of branching morphogenesis of a nerve Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. go.json http://purl.obolibrary.org/obo/GO_2000173 GO:0120321 biolink:CellularComponent nuclear envelope adjacent to nuclear pore complex The region of the nuclear envelope situated in close proximity to a nuclear pore complex. go.json associated with the nuclear pore|nuclear envelope adjacent to NPC|nuclear envelope periphery of the nuclear pore complex http://purl.obolibrary.org/obo/GO_0120321 GO:2000174 biolink:BiologicalProcess regulation of pro-T cell differentiation Any process that modulates the frequency, rate or extent of pro-T cell differentiation. go.json regulation of pro-T lymphocyte differentiation http://purl.obolibrary.org/obo/GO_2000174 GO:0036366 biolink:BiologicalProcess transforming growth factor beta3 activation The release of transforming growth factor beta 3 (TGF-beta3) from its latent state. go.json TGF-beta 3 activation|TGFB3 activation|TGFbeta 3 activation http://purl.obolibrary.org/obo/GO_0036366 GO:0120322 biolink:BiologicalProcess lipid modification by small protein conjugation A lipid modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target lipid. go.json http://purl.obolibrary.org/obo/GO_0120322 GO:0036367 biolink:BiologicalProcess light adaption The ability of a photoreceptor to adjust to varying levels of light. go.json http://purl.obolibrary.org/obo/GO_0036367 GO:2000175 biolink:BiologicalProcess negative regulation of pro-T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. go.json negative regulation of pro-T lymphocyte differentiation http://purl.obolibrary.org/obo/GO_2000175 GO:0120323 biolink:BiologicalProcess lipid ubiquitination The process in which one or more ubiquitin groups are added to a lipid. go.json http://purl.obolibrary.org/obo/GO_0120323 GO:0036368 biolink:BiologicalProcess cone photoresponse recovery The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers. go.json cone phototransduction termination|cone response recovery http://purl.obolibrary.org/obo/GO_0036368 GO:2000176 biolink:BiologicalProcess positive regulation of pro-T cell differentiation Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. go.json positive regulation of pro-T lymphocyte differentiation http://purl.obolibrary.org/obo/GO_2000176 GO:0120324 biolink:BiologicalProcess procyclogenesis The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei. go.json http://purl.obolibrary.org/obo/GO_0120324 GO:0036369 biolink:BiologicalProcess obsolete transcription factor catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. go.json proteasome-mediated transcription factor catabolism|sequence-specific DNA binding transcription factor catabolic process|transcription factor breakdown|transcription factor catabolism|transcription factor degradation True http://purl.obolibrary.org/obo/GO_0036369 GO:2000177 biolink:BiologicalProcess regulation of neural precursor cell proliferation Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000177 GO:2000178 biolink:BiologicalProcess negative regulation of neural precursor cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000178 GO:2000179 biolink:BiologicalProcess positive regulation of neural precursor cell proliferation Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000179 GO:0120320 biolink:BiologicalProcess lateral pseudopodium retraction The myosin-based contraction and retraction of a lateral pseudopodium. go.json lateral pseudopodium suppression http://purl.obolibrary.org/obo/GO_0120320 GO:0036360 biolink:BiologicalProcess sorocarp stalk morphogenesis The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum. go.json fruiting body stalk morphogenesis http://purl.obolibrary.org/obo/GO_0036360 GO:0036361 biolink:MolecularActivity racemase activity, acting on amino acids and derivatives Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. go.json http://purl.obolibrary.org/obo/GO_0036361 GO:0051980 biolink:MolecularActivity iron-nicotianamine transmembrane transporter activity Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other. go.json Fe-NA chelate transporter activity http://purl.obolibrary.org/obo/GO_0051980 GO:2000170 biolink:BiologicalProcess positive regulation of peptidyl-cysteine S-nitrosylation Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation. go.json http://purl.obolibrary.org/obo/GO_2000170 GO:0036362 biolink:CellularComponent ascus membrane A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi. go.json http://purl.obolibrary.org/obo/GO_0036362 GO:0051981 biolink:MolecularActivity copper chelate transmembrane transporter activity Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. go.json http://purl.obolibrary.org/obo/GO_0051981 GO:0036363 biolink:BiologicalProcess transforming growth factor beta activation The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms. go.json L-TGF-beta activation|TGF-B activation|TGF-beta activation|TGFB activation|TGFbeta activation|latent TGF-beta activation http://purl.obolibrary.org/obo/GO_0036363 GO:2000171 biolink:BiologicalProcess negative regulation of dendrite development Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. go.json http://purl.obolibrary.org/obo/GO_2000171 GO:0036364 biolink:BiologicalProcess transforming growth factor beta1 activation The release of transforming growth factor beta1 (TGF-beta1) from its latent state. go.json L-TGF-beta 1 activation|TGF-beta 1 activation|TGFB1 activation|TGFbeta 1 activation|latent-TGF-beta1 activation|transforming growth factor-beta1 activation http://purl.obolibrary.org/obo/GO_0036364 GO:2000172 biolink:BiologicalProcess regulation of branching morphogenesis of a nerve Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. go.json http://purl.obolibrary.org/obo/GO_2000172 GO:0120178 biolink:BiologicalProcess steroid hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. go.json http://purl.obolibrary.org/obo/GO_0120178 GO:0120179 biolink:BiologicalProcess adherens junction disassembly The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json http://purl.obolibrary.org/obo/GO_0120179 GO:0120174 biolink:BiologicalProcess stress-induced homeostatically regulated protein degradation pathway A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway. go.json SHRED pathway http://purl.obolibrary.org/obo/GO_0120174 GO:0120175 biolink:BiologicalProcess regulation of torso signaling pathway Any process that modulates the frequency, rate or extent of the torso signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120175 GO:0120176 biolink:BiologicalProcess positive regulation of torso signaling pathway Any process that activates or increases the frequency, rate or extent of the torso signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120176 GO:0120177 biolink:BiologicalProcess negative regulation of torso signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120177 GO:0120170 biolink:MolecularActivity intraciliary transport particle B binding Binding to an intraciliary transport particle B (IFT B) complex. go.json IFT B complex binding|intraciliary transport complex B binding|intraflagellar transport complex B binding|intraflagellar transport particle B binding http://purl.obolibrary.org/obo/GO_0120170 GO:0120171 biolink:CellularComponent Cdc24p-Far1p-Gbetagamma complex A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit). go.json CDC24-FAR1-BG complex|CDC24-FAR1-Gbetagamma complex|Cdc24p-Far1p-BG complex http://purl.obolibrary.org/obo/GO_0120171 GO:0120172 biolink:BiologicalProcess obsolete positive regulation of actin filament bundle convergence involved in mitotic contractile ring assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly. go.json True http://purl.obolibrary.org/obo/GO_0120172 GO:0120173 biolink:BiologicalProcess obsolete regulation of actin filament bundle convergence involved in mitotic contractile ring assembly OBSOLETE. Any process that modulates the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly. go.json True http://purl.obolibrary.org/obo/GO_0120173 GO:0120189 biolink:BiologicalProcess positive regulation of bile acid secretion Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0120189 GO:0120185 biolink:BiologicalProcess MBF transcription complex assembly The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex. go.json DSC1 transcription factor complex assembly|MBF complex assembly|Mlu1-box binding factor assembly http://purl.obolibrary.org/obo/GO_0120185 GO:0120186 biolink:BiologicalProcess negative regulation of protein localization to chromatin Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. go.json negative regulation of protein localisation to chromatin http://purl.obolibrary.org/obo/GO_0120186 GO:0120187 biolink:BiologicalProcess positive regulation of protein localization to chromatin Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. go.json positive regulation of protein localisation to chromatin http://purl.obolibrary.org/obo/GO_0120187 GO:0120188 biolink:BiologicalProcess regulation of bile acid secretion Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0120188 GO:0120181 biolink:BiologicalProcess focal adhesion disassembly The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity. go.json http://purl.obolibrary.org/obo/GO_0120181 GO:0120182 biolink:BiologicalProcess regulation of focal adhesion disassembly Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0120182 GO:0120183 biolink:BiologicalProcess positive regulation of focal adhesion disassembly Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0120183 GO:0120184 biolink:BiologicalProcess negative regulation of focal adhesion disassembly Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0120184 GO:0120180 biolink:BiologicalProcess cell-substrate junction disassembly The disaggregation of a cell-substrate junction into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0120180 GO:0120196 biolink:BiologicalProcess negative regulation of anther dehiscence Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence. go.json http://purl.obolibrary.org/obo/GO_0120196 GO:0120197 biolink:BiologicalProcess mucociliary clearance The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways. go.json MCC|MCT|mucociliary transport http://purl.obolibrary.org/obo/GO_0120197 GO:0120198 biolink:BiologicalProcess positive regulation of imaginal disc-derived wing size Any process that increases the size of an imaginal disc-derived wing. go.json http://purl.obolibrary.org/obo/GO_0120198 GO:0120199 biolink:CellularComponent cone photoreceptor outer segment The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins. go.json http://purl.obolibrary.org/obo/GO_0120199 GO:0120192 biolink:BiologicalProcess tight junction assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. go.json occluding cell junction assembly|occluding junction assembly http://purl.obolibrary.org/obo/GO_0120192 GO:0120193 biolink:BiologicalProcess tight junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. go.json occluding cell junction organization|occluding junction organization http://purl.obolibrary.org/obo/GO_0120193 GO:0120194 biolink:BiologicalProcess regulation of anther dehiscence Any process involved in the dehiscence of an anther to release the pollen grains contained within it. go.json http://purl.obolibrary.org/obo/GO_0120194 GO:0120195 biolink:BiologicalProcess positive regulation of anther dehiscence Any process that activates or increases the frequency, rate or extent of anther dehiscence. go.json http://purl.obolibrary.org/obo/GO_0120195 GO:0120190 biolink:BiologicalProcess negative regulation of bile acid secretion Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0120190 GO:0120191 biolink:BiologicalProcess negative regulation of termination of RNA polymerase II transcription Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription. go.json down regulation of RNA 3'-end formation by RNA polymerase II|down regulation of RNA polymerase II transcription termination|down regulation of RNA polymerase II transcription termination factor activity|down regulation of termination of RNA polymerase II transcription|down regulation of transcription termination from Pol II promoter|down regulation of transcription termination from RNA polymerase II promoter|down-regulation of RNA 3'-end formation by RNA polymerase II|down-regulation of RNA polymerase II transcription termination|down-regulation of RNA polymerase II transcription termination factor activity|down-regulation of termination of RNA polymerase II transcription|down-regulation of transcription termination from Pol II promoter|down-regulation of transcription termination from RNA polymerase II promoter|downregulation of RNA 3'-end formation by RNA polymerase II|downregulation of RNA polymerase II transcription termination|downregulation of RNA polymerase II transcription termination factor activity|downregulation of termination of RNA polymerase II transcription|downregulation of transcription termination from Pol II promoter|downregulation of transcription termination from RNA polymerase II promoter|negative regulation of RNA 3'-end formation by RNA polymerase II|negative regulation of RNA polymerase II transcription termination|negative regulation of RNA polymerase II transcription termination factor activity|negative regulation of transcription termination from Pol II promoter|negative regulation of transcription termination from RNA polymerase II promoter|repression of RNA 3'-end formation by RNA polymerase II|repression of RNA polymerase II transcription termination|repression of RNA polymerase II transcription termination factor activity|repression of termination of RNA polymerase II transcription|repression of transcription termination from Pol II promoter|repression of transcription termination from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0120191 GO:0120138 biolink:BiologicalProcess regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_0120138 gocheck_do_not_annotate GO:0120139 biolink:BiologicalProcess positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_0120139 gocheck_do_not_annotate GO:0120134 biolink:CellularComponent proximal portion of axoneme The portion of the axoneme that is close to the base of the cilium. go.json proximal part of axoneme http://purl.obolibrary.org/obo/GO_0120134 GO:0120135 biolink:CellularComponent distal portion of axoneme The portion of the axoneme that is close to the tip of the cilium. go.json distal part of axoneme http://purl.obolibrary.org/obo/GO_0120135 GO:0120136 biolink:MolecularActivity dUMP kinase activity Catalysis of the reaction: ATP + dUMP = ADP + dUDP. RHEA:30655 go.json ATP:dUMP phosphotransferase activity|dUMP-kinase activity|deoxyuridine monophosphate kinase activity http://purl.obolibrary.org/obo/GO_0120136 GO:0120137 biolink:BiologicalProcess positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. go.json http://purl.obolibrary.org/obo/GO_0120137 gocheck_do_not_annotate GO:0120132 biolink:BiologicalProcess positive regulation of apoptotic process in bone marrow cell Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow. go.json activation of apoptosis in bone marrow|positive regulation of apoptosis in bone marrow|positive regulation of apoptotic process in bone marrow|positive regulation of bone marrow cell apoptosis|positive regulation of bone marrow cell programmed cell death by apoptosis|positive regulation of killing of bone marrow cells|positive regulation of programmed cell death of bone marrow cells by apoptosis|positive regulation of programmed cell death, bone marrow cells|up regulation of apoptosis in bone marrow|up-regulation of apoptosis in bone marrow|upregulation of apoptosis in bone marrow http://purl.obolibrary.org/obo/GO_0120132 GO:0120133 biolink:BiologicalProcess negative regulation of actin cortical patch assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches. go.json down regulation of actin cortical patch assembly|down-regulation of actin cortical patch assembly|downregulation of actin cortical patch assembly|inhibition of actin cortical patch assembly http://purl.obolibrary.org/obo/GO_0120133 GO:0120149 biolink:CellularComponent host cell peroxisome A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. go.json host peroxisome http://purl.obolibrary.org/obo/GO_0120149 GO:0120145 biolink:BiologicalProcess protein localization to basal ectoplasmic specialization A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization. go.json protein localisation in basal ectoplasmic specialization|protein localisation to basal ectoplasmic specialization|protein localization in basal ectoplasmic specialization http://purl.obolibrary.org/obo/GO_0120145 GO:0120146 biolink:MolecularActivity sulfatide binding Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group. go.json 3-O-sulfogalactosylceramide binding|SM4 binding|sulfated galactocerebroside binding http://purl.obolibrary.org/obo/GO_0120146 GO:0120147 biolink:MolecularActivity formylglycine-generating oxidase activity Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O. EC:1.8.3.7|MetaCyc:RXN-16226|RHEA:51152 go.json http://purl.obolibrary.org/obo/GO_0120147 GO:0120148 biolink:CellularComponent host cell centrosome A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. go.json host centrosome http://purl.obolibrary.org/obo/GO_0120148 GO:0120141 biolink:BiologicalProcess regulation of ecdysone receptor-mediated signaling pathway Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor-mediated signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120141 GO:0120142 biolink:BiologicalProcess positive regulation of ecdysone receptor-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120142 GO:0120143 biolink:BiologicalProcess negative regulation of ecdysone receptor-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120143 GO:0120140 biolink:BiologicalProcess negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_0120140 gocheck_do_not_annotate GO:0120157 biolink:CellularComponent PAR polarity complex A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. go.json BEM1-CDC24-CLA4 complex|Cdc42p GEF-PAK complex|PAR3-PAR6-atypical PKC|PAR3/PAR6/aPKC|PAR6-PAR3-aPKC complex|apical polarity complex http://purl.obolibrary.org/obo/GO_0120157 GO:0120158 biolink:BiologicalProcess positive regulation of collagen catabolic process Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. go.json activation of collagen catabolic process|positive regulation of collagen breakdown|positive regulation of collagen catabolism|positive regulation of collagen degradation|up regulation of collagen catabolic process|up-regulation of collagen catabolic process|upregulation of collagen catabolic process http://purl.obolibrary.org/obo/GO_0120158 GO:0120159 biolink:MolecularActivity rRNA pseudouridine synthase activity Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. EC:5.4.99.19|EC:5.4.99.20|EC:5.4.99.21|EC:5.4.99.22|EC:5.4.99.23|EC:5.4.99.24|EC:5.4.99.29|EC:5.4.99.43 go.json 16S rRNA pseudouridine(516) synthase|21S rRNA pseudouridine(2819) synthase|23S rRNA pseudouridine(1911/1915/1917) synthase|23S rRNA pseudouridine(2457) synthase|23S rRNA pseudouridine(2604) synthase|23S rRNA pseudouridine(2605) synthase|23S rRNA pseudouridine(746) synthase|23S rRNA pseudouridine(955/2504/2580) synthase http://purl.obolibrary.org/obo/GO_0120159 GO:0120152 biolink:MolecularActivity calcium-dependent outer dynein arm binding Binding to an outer dynein arm in the presence of calcium. go.json http://purl.obolibrary.org/obo/GO_0120152 GO:0120153 biolink:MolecularActivity calcium-dependent carbohydrate binding Binding to a carbohydrate in the presence of calcium. go.json http://purl.obolibrary.org/obo/GO_0120153 GO:0120154 biolink:BiologicalProcess negative regulation of ERBB4 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0120154 GO:0120155 biolink:CellularComponent MIH complex A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins. go.json Mlc1p-Iqg1p-Hof1p complex http://purl.obolibrary.org/obo/GO_0120155 GO:0120150 biolink:BiologicalProcess regulation of mitotic actomyosin contractile ring disassembly Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring disassembly. go.json regulation of mitotic CAR disassembly|regulation of mitotic actomyosin ring disassembly|regulation of mitotic constriction ring disassembly|regulation of mitotic contractile actomyosin ring disassembly|regulation of mitotic cytokinetic ring disassembly http://purl.obolibrary.org/obo/GO_0120150 GO:0120151 biolink:BiologicalProcess positive regulation of mitotic actomyosin contractile ring disassembly Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring disassembly. go.json positive regulation of mitotic CAR disassembly|positive regulation of mitotic actomyosin ring disassembly|positive regulation of mitotic constriction ring disassembly|positive regulation of mitotic contractile actomyosin ring disassembly|positive regulation of mitotic cytokinetic ring disassembly http://purl.obolibrary.org/obo/GO_0120151 GO:0120168 biolink:BiologicalProcess detection of hot stimulus involved in thermoception The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception. go.json sensory detection of heat stimulus during thermoception|sensory detection of hot stimulus during thermoception|sensory transduction of heat stimulus during thermoception|sensory transduction of hot stimulus during thermoception|thermoception, sensory detection of heat stimulus|thermoception, sensory detection of hot stimulus|thermoception, sensory transduction of heat stimulus|thermoception, sensory transduction of hot stimulus http://purl.obolibrary.org/obo/GO_0120168 GO:0120169 biolink:BiologicalProcess detection of cold stimulus involved in thermoception The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception. go.json sensory detection of cold stimulus during thermoception|sensory transduction of cold stimulus during thermoception|thermoception, sensory detection of cold stimulus|thermoception, sensory transduction of cold stimulus http://purl.obolibrary.org/obo/GO_0120169 GO:0120163 biolink:BiologicalProcess negative regulation of cold-induced thermogenesis Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. go.json negative regulation of CIT http://purl.obolibrary.org/obo/GO_0120163 GO:0120164 biolink:BiologicalProcess conidium germination The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination. go.json http://purl.obolibrary.org/obo/GO_0120164 GO:0120165 biolink:BiologicalProcess perithecium development The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck. go.json http://purl.obolibrary.org/obo/GO_0120165 GO:0120166 biolink:BiologicalProcess protoperithecium formation The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium. go.json http://purl.obolibrary.org/obo/GO_0120166 GO:0120160 biolink:MolecularActivity intraciliary transport particle A binding Binding to an intraciliary transport particle A (IFT A) complex. go.json IFT A complex binding|intraciliary transport complex A binding|intraflagellar transport complex A binding|intraflagellar transport particle A binding http://purl.obolibrary.org/obo/GO_0120160 GO:0120161 biolink:BiologicalProcess regulation of cold-induced thermogenesis Any process that modulates the frequency, rate or extent of cold-induced thermogenesis. go.json regulation of CIT http://purl.obolibrary.org/obo/GO_0120161 GO:0120162 biolink:BiologicalProcess positive regulation of cold-induced thermogenesis Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. go.json positive regulation of CIT http://purl.obolibrary.org/obo/GO_0120162 GO:0036516 biolink:BiologicalProcess chemoattraction of dopaminergic neuron axon The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal. go.json chemoattraction of DA axon|chemoattraction of dopaminergic axon http://purl.obolibrary.org/obo/GO_0036516 GO:0036517 biolink:BiologicalProcess chemoattraction of serotonergic neuron axon The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal. go.json chemoattraction of 5-HT axon|chemoattraction of serotonergic axon http://purl.obolibrary.org/obo/GO_0036517 GO:1901048 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. go.json TGF-beta receptor signaling pathway of regulation of body growth|TGF-beta receptor signaling pathway of regulation of body size|TGF-beta receptor signaling pathway of regulation of multicellular organism growth|TGF-beta receptor signalling pathway of regulation of body growth|TGF-beta receptor signalling pathway of regulation of body size|TGF-beta receptor signalling pathway of regulation of multicellular organism growth|TGFbeta receptor signaling pathway of regulation of body growth|TGFbeta receptor signaling pathway of regulation of body size|TGFbeta receptor signaling pathway of regulation of multicellular organism growth|TGFbeta receptor signalling pathway of regulation of body growth|TGFbeta receptor signalling pathway of regulation of body size|TGFbeta receptor signalling pathway of regulation of multicellular organism growth|transforming growth factor beta receptor signaling pathway of regulation of body growth|transforming growth factor beta receptor signaling pathway of regulation of body size|transforming growth factor beta receptor signaling pathway of regulation of multicellular organism growth|transforming growth factor beta receptor signalling pathway of regulation of body growth|transforming growth factor beta receptor signalling pathway of regulation of body size|transforming growth factor beta receptor signalling pathway of regulation of multicellular organism growth True http://purl.obolibrary.org/obo/GO_1901048 GO:0036518 biolink:BiologicalProcess chemorepulsion of dopaminergic neuron axon The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. go.json chemorepulsion of DA axon|chemorepulsion of dopaminergic axon http://purl.obolibrary.org/obo/GO_0036518 GO:1901049 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901049 GO:0036519 biolink:BiologicalProcess chemorepulsion of serotonergic neuron axon The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. go.json chemorepulsion of 5-HT axon|chemorepulsion of serotonergic axon http://purl.obolibrary.org/obo/GO_0036519 GO:1901046 biolink:BiologicalProcess positive regulation of egg-laying behavior Any process that activates or increases the frequency, rate or extent of oviposition. go.json activation of egg laying|activation of egg-laying|activation of oviposition|positive regulation of egg laying|positive regulation of egg-laying|positive regulation of oviposition|up regulation of egg laying|up regulation of egg-laying|up regulation of oviposition|up-regulation of egg laying|up-regulation of egg-laying|up-regulation of oviposition|upregulation of egg laying|upregulation of egg-laying|upregulation of oviposition http://purl.obolibrary.org/obo/GO_1901046 GO:1901047 biolink:BiologicalProcess obsolete insulin receptor signaling pathway involved in determination of adult lifespan OBSOLETE. The series of molecular signals generated as a consequence of the insulin receptor binding to insulin that controls viability and duration in the adult phase of the life-cycle. go.json daf-2 receptor signaling pathway of determination of adult lifespan|insulin receptor signaling pathway of determination of adult lifespan|insulin receptor signalling pathway of determination of adult lifespan True http://purl.obolibrary.org/obo/GO_1901047 GO:1901044 biolink:BiologicalProcess obsolete protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process OBSOLETE. Any protein polyubiquitination that is involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process. go.json True http://purl.obolibrary.org/obo/GO_1901044 GO:1901045 biolink:BiologicalProcess negative regulation of egg-laying behavior Any process that stops, prevents or reduces the frequency, rate or extent of oviposition. go.json down regulation of egg laying|down regulation of egg-laying|down regulation of oviposition|down-regulation of egg laying|down-regulation of egg-laying|down-regulation of oviposition|downregulation of egg laying|downregulation of egg-laying|downregulation of oviposition|inhibition of egg laying|inhibition of egg-laying|inhibition of oviposition|negative regulation of egg laying|negative regulation of egg-laying|negative regulation of oviposition http://purl.obolibrary.org/obo/GO_1901045 GO:1901053 biolink:BiologicalProcess sarcosine catabolic process The chemical reactions and pathways resulting in the breakdown of sarcosine. go.json sarcosine breakdown|sarcosine catabolism|sarcosine degradation http://purl.obolibrary.org/obo/GO_1901053 GO:1901054 biolink:BiologicalProcess sarcosine biosynthetic process The chemical reactions and pathways resulting in the formation of sarcosine. go.json sarcosine anabolism|sarcosine biosynthesis|sarcosine formation|sarcosine synthesis http://purl.obolibrary.org/obo/GO_1901054 GO:0036510 biolink:BiologicalProcess trimming of terminal mannose on C branch The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. go.json conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2|conversion of M9 to M8C|glycoprotein mannose trimming on C branch http://purl.obolibrary.org/obo/GO_0036510 gocheck_do_not_annotate GO:1901051 biolink:BiologicalProcess atropine biosynthetic process The chemical reactions and pathways resulting in the formation of atropine. Atropine is the racemic mixture of hyoscyamine. go.json atropine anabolism|atropine biosynthesis|atropine formation|atropine metabolic process|atropine metabolism|atropine synthesis|hyoscyamine biosynthetic process http://purl.obolibrary.org/obo/GO_1901051 GO:0036511 biolink:BiologicalProcess trimming of first mannose on A branch The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. go.json conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2|conversion of M9 to M8A|glycoprotein mannose trimming on A branch http://purl.obolibrary.org/obo/GO_0036511 gocheck_do_not_annotate GO:1901052 biolink:BiologicalProcess sarcosine metabolic process The chemical reactions and pathways involving sarcosine. go.json sarcosine metabolism http://purl.obolibrary.org/obo/GO_1901052 GO:0036512 biolink:BiologicalProcess trimming of second mannose on A branch The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. go.json conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2|conversion of M8A to M7AA|glycoprotein mannose trimming on A branch http://purl.obolibrary.org/obo/GO_0036512 gocheck_do_not_annotate GO:0036513 biolink:CellularComponent Derlin-1 retrotranslocation complex A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. go.json Derlin-1 complex|Derlin-1 protein dislocation complex|Derlin-1 retro-translocation complex|Derlin-1 retrotranslocon|ERAD protein dislocation complex http://purl.obolibrary.org/obo/GO_0036513 GO:1901050 biolink:BiologicalProcess obsolete atropine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atropine. go.json atropine breakdown|atropine catabolism|atropine degradation True http://purl.obolibrary.org/obo/GO_1901050 GO:0036514 biolink:BiologicalProcess dopaminergic neuron axon guidance The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues. go.json DA axon guidance|dopaminergic axon guidance|mdDA axon guidance http://purl.obolibrary.org/obo/GO_0036514 GO:0036515 biolink:BiologicalProcess serotonergic neuron axon guidance The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues. go.json 5-HT axon guidance|serotonergic axon guidance http://purl.obolibrary.org/obo/GO_0036515 GO:0036505 biolink:MolecularActivity prosaposin receptor activity Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D). go.json prosaposin-activated receptor activity http://purl.obolibrary.org/obo/GO_0036505 GO:0036506 biolink:BiologicalProcess maintenance of unfolded protein Maintaining a protein in an unfolded, soluble state. go.json http://purl.obolibrary.org/obo/GO_0036506 GO:0036507 biolink:BiologicalProcess protein demannosylation The removal of one or more mannose residues from a mannosylated protein. go.json protein de-mannosylation http://purl.obolibrary.org/obo/GO_0036507 gocheck_do_not_annotate GO:1901059 biolink:BiologicalProcess p-hydroxyphenyl lignin catabolic process The chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin. go.json H-lignin catabolic process|p-hydroxyphenyl lignin breakdown|p-hydroxyphenyl lignin catabolism|p-hydroxyphenyl lignin degradation http://purl.obolibrary.org/obo/GO_1901059 GO:0036508 biolink:BiologicalProcess protein alpha-1,2-demannosylation The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. go.json glycoprotein mannose trimming|mannose trimming http://purl.obolibrary.org/obo/GO_0036508 gocheck_do_not_annotate GO:1901057 biolink:BiologicalProcess trimethylenediamine biosynthetic process The chemical reactions and pathways resulting in the formation of trimethylenediamine. go.json trimethylenediamine anabolism|trimethylenediamine biosynthesis|trimethylenediamine formation|trimethylenediamine synthesis http://purl.obolibrary.org/obo/GO_1901057 GO:0036509 biolink:BiologicalProcess trimming of terminal mannose on B branch The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. KEGG_REACTION:R06722 go.json conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2|conversion of M9 to M8B|glycoprotein mannose trimming on B branch http://purl.obolibrary.org/obo/GO_0036509 gocheck_do_not_annotate GO:1901058 biolink:BiologicalProcess p-hydroxyphenyl lignin metabolic process The chemical reactions and pathways involving p-hydroxyphenyl lignin. go.json H-lignin metabolic process|p-hydroxyphenyl lignin metabolism http://purl.obolibrary.org/obo/GO_1901058 GO:1901055 biolink:BiologicalProcess trimethylenediamine metabolic process The chemical reactions and pathways involving trimethylenediamine. go.json trimethylenediamine metabolism http://purl.obolibrary.org/obo/GO_1901055 GO:1901056 biolink:BiologicalProcess trimethylenediamine catabolic process The chemical reactions and pathways resulting in the breakdown of trimethylenediamine. go.json trimethylenediamine breakdown|trimethylenediamine catabolism|trimethylenediamine degradation http://purl.obolibrary.org/obo/GO_1901056 GO:1901064 biolink:BiologicalProcess syringal lignin metabolic process The chemical reactions and pathways involving syringal lignin. go.json S-lignin metabolic process|syringal lignin metabolism http://purl.obolibrary.org/obo/GO_1901064 GO:1901065 biolink:BiologicalProcess syringal lignin catabolic process The chemical reactions and pathways resulting in the breakdown of syringal lignin. go.json S-lignin catabolic process|syringal lignin breakdown|syringal lignin catabolism|syringal lignin degradation http://purl.obolibrary.org/obo/GO_1901065 GO:1901062 biolink:BiologicalProcess guaiacyl lignin catabolic process The chemical reactions and pathways resulting in the breakdown of guaiacyl lignin. go.json G-lignin catabolic process|guaiacyl lignin breakdown|guaiacyl lignin catabolism|guaiacyl lignin degradation http://purl.obolibrary.org/obo/GO_1901062 GO:0036500 biolink:BiologicalProcess ATF6-mediated unfolded protein response The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. go.json ATF6 branch of UPR|ATF6 signal transduction pathway|ATF6 signaling in response to endoplasmic reticulum stress|ATF6-alpha UPR branch|ATF6-beta UPR branch|UPR signaling by ATF6 stress sensor|activating transcription factor 6 signaling in unfolded protein response|endoplasmic reticulum unfolded protein response; ATF6 signaling http://purl.obolibrary.org/obo/GO_0036500 GO:1901063 biolink:BiologicalProcess guaiacyl lignin biosynthetic process The chemical reactions and pathways resulting in the formation of guaiacyl lignin. go.json G-lignin biosynthetic process|guaiacyl lignin anabolism|guaiacyl lignin biosynthesis|guaiacyl lignin formation|guaiacyl lignin synthesis http://purl.obolibrary.org/obo/GO_1901063 GO:1901060 biolink:BiologicalProcess p-hydroxyphenyl lignin biosynthetic process The chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin. go.json H-lignin biosynthetic process|p-hydroxyphenyl lignin anabolism|p-hydroxyphenyl lignin biosynthesis|p-hydroxyphenyl lignin formation|p-hydroxyphenyl lignin synthesis http://purl.obolibrary.org/obo/GO_1901060 GO:0036501 biolink:CellularComponent UFD1-NPL4 complex A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. go.json Npl4p-Ufd1p complex|UFD1L-NPLOC4 complex|Ufd1-Npl4 binary complex|Ufd1-Npl4 cofactor complex|Ufd1/Npl4 complex http://purl.obolibrary.org/obo/GO_0036501 GO:0036502 biolink:CellularComponent Derlin-1-VIMP complex A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome. go.json Derlin-1/VIMP complex http://purl.obolibrary.org/obo/GO_0036502 GO:1901061 biolink:BiologicalProcess guaiacyl lignin metabolic process The chemical reactions and pathways involving guaiacyl lignin. go.json G-lignin metabolic process|guaiacyl lignin metabolism http://purl.obolibrary.org/obo/GO_1901061 GO:0036503 biolink:BiologicalProcess ERAD pathway The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. go.json ER-associated degradation pathway|endoplasmic reticulum-associated degradation|endoplasmic reticulum-associated protein degradation pathway|protein degradation by ERAD http://purl.obolibrary.org/obo/GO_0036503 GO:0036504 biolink:BiologicalProcess Golgi membrane fusion The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. go.json Golgi apparatus membrane fusion|membrane fusion involved in Golgi reassembly|post-mitotic fusion of Golgi membranes http://purl.obolibrary.org/obo/GO_0036504 GO:1901068 biolink:BiologicalProcess guanosine-containing compound metabolic process The chemical reactions and pathways involving guanosine-containing compounds (guanosines). go.json guanosine-containing compound metabolism|guanosines metabolic process|guanosines metabolism http://purl.obolibrary.org/obo/GO_1901068 GO:1901069 biolink:BiologicalProcess guanosine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines). go.json guanosine-containing compound breakdown|guanosine-containing compound catabolism|guanosine-containing compound degradation|guanosines breakdown|guanosines catabolic process|guanosines catabolism|guanosines degradation http://purl.obolibrary.org/obo/GO_1901069 GO:1901066 biolink:BiologicalProcess syringal lignin biosynthetic process The chemical reactions and pathways resulting in the formation of syringal lignin. go.json S-lignin biosynthetic process|syringal lignin anabolism|syringal lignin biosynthesis|syringal lignin formation|syringal lignin synthesis http://purl.obolibrary.org/obo/GO_1901066 GO:1901067 biolink:BiologicalProcess ferulate catabolic process The chemical reactions and pathways resulting in the breakdown of ferulate. go.json ferulate breakdown|ferulate catabolism|ferulate degradation http://purl.obolibrary.org/obo/GO_1901067 GO:1901075 biolink:BiologicalProcess negative regulation of engulfment of apoptotic cell Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell. go.json down regulation of engulfment of apoptotic cell|down regulation of engulfment of apoptotic cell corpse|down regulation of engulfment of cell corpse|down-regulation of engulfment of apoptotic cell|down-regulation of engulfment of apoptotic cell corpse|down-regulation of engulfment of cell corpse|downregulation of engulfment of apoptotic cell|downregulation of engulfment of apoptotic cell corpse|downregulation of engulfment of cell corpse|inhibition of engulfment of apoptotic cell|inhibition of engulfment of apoptotic cell corpse|inhibition of engulfment of cell corpse|negative regulation of engulfment of apoptotic cell corpse|negative regulation of engulfment of cell corpse http://purl.obolibrary.org/obo/GO_1901075 GO:1901076 biolink:BiologicalProcess positive regulation of engulfment of apoptotic cell Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell. go.json activation of engulfment of apoptotic cell|activation of engulfment of apoptotic cell corpse|activation of engulfment of cell corpse|positive regulation of engulfment of apoptotic cell corpse|positive regulation of engulfment of cell corpse|up regulation of engulfment of apoptotic cell|up regulation of engulfment of apoptotic cell corpse|up regulation of engulfment of cell corpse|up-regulation of engulfment of apoptotic cell|up-regulation of engulfment of apoptotic cell corpse|up-regulation of engulfment of cell corpse|upregulation of engulfment of apoptotic cell|upregulation of engulfment of apoptotic cell corpse|upregulation of engulfment of cell corpse http://purl.obolibrary.org/obo/GO_1901076 GO:1901073 biolink:BiologicalProcess glucosamine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines). go.json glucosamine-containing compound anabolism|glucosamine-containing compound biosynthesis|glucosamine-containing compound formation|glucosamine-containing compound synthesis|glucosamines anabolism|glucosamines biosynthesis|glucosamines biosynthetic process|glucosamines formation|glucosamines synthesis http://purl.obolibrary.org/obo/GO_1901073 GO:1901074 biolink:BiologicalProcess regulation of engulfment of apoptotic cell Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell. go.json regulation of engulfment of apoptotic cell corpse|regulation of engulfment of cell corpse http://purl.obolibrary.org/obo/GO_1901074 GO:1901071 biolink:BiologicalProcess glucosamine-containing compound metabolic process The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). go.json glucosamine-containing compound metabolism|glucosamines metabolic process|glucosamines metabolism http://purl.obolibrary.org/obo/GO_1901071 GO:1901072 biolink:BiologicalProcess glucosamine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines). go.json glucosamine-containing compound breakdown|glucosamine-containing compound catabolism|glucosamine-containing compound degradation|glucosamines breakdown|glucosamines catabolic process|glucosamines catabolism|glucosamines degradation http://purl.obolibrary.org/obo/GO_1901072 GO:1901070 biolink:BiologicalProcess guanosine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). go.json guanosine-containing compound anabolism|guanosine-containing compound biosynthesis|guanosine-containing compound formation|guanosine-containing compound synthesis|guanosines anabolism|guanosines biosynthesis|guanosines biosynthetic process|guanosines formation|guanosines synthesis http://purl.obolibrary.org/obo/GO_1901070 GO:1901079 biolink:BiologicalProcess positive regulation of relaxation of muscle Any process that activates or increases the frequency, rate or extent of relaxation of muscle. go.json activation of relaxation of muscle|up regulation of relaxation of muscle|up-regulation of relaxation of muscle|upregulation of relaxation of muscle http://purl.obolibrary.org/obo/GO_1901079 GO:1901077 biolink:BiologicalProcess regulation of relaxation of muscle Any process that modulates the frequency, rate or extent of relaxation of muscle. go.json http://purl.obolibrary.org/obo/GO_1901077 GO:1901078 biolink:BiologicalProcess negative regulation of relaxation of muscle Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle. go.json down regulation of relaxation of muscle|down-regulation of relaxation of muscle|downregulation of relaxation of muscle|inhibition of relaxation of muscle http://purl.obolibrary.org/obo/GO_1901078 GO:1901086 biolink:BiologicalProcess benzylpenicillin metabolic process The chemical reactions and pathways involving benzylpenicillin. go.json benzylpenicillin metabolism|penicillin G metabolism http://purl.obolibrary.org/obo/GO_1901086 GO:1901087 biolink:BiologicalProcess benzylpenicillin catabolic process The chemical reactions and pathways resulting in the breakdown of benzylpenicillin. go.json benzylpenicillin breakdown|benzylpenicillin catabolism|benzylpenicillin degradation|penicillin G breakdown|penicillin G catabolic process|penicillin G catabolism|penicillin G degradation http://purl.obolibrary.org/obo/GO_1901087 GO:1901084 biolink:BiologicalProcess obsolete pyrrolizidine alkaloid catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of pyrrolizidine alkaloid. go.json pyrrolizidine alkaloid breakdown|pyrrolizidine alkaloid catabolism|pyrrolizidine alkaloid degradation True http://purl.obolibrary.org/obo/GO_1901084 GO:1901085 biolink:BiologicalProcess pyrrolizidine alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid. go.json pyrrolizidine alkaloid anabolism|pyrrolizidine alkaloid biosynthesis|pyrrolizidine alkaloid formation|pyrrolizidine alkaloid synthesis http://purl.obolibrary.org/obo/GO_1901085 GO:1901082 biolink:BiologicalProcess positive regulation of relaxation of smooth muscle Any process that activates or increases the frequency, rate or extent of relaxation of smooth muscle. go.json activation of relaxation of smooth muscle|activation of smooth muscle relaxation|positive regulation of smooth muscle relaxation|up regulation of relaxation of smooth muscle|up regulation of smooth muscle relaxation|up-regulation of relaxation of smooth muscle|up-regulation of smooth muscle relaxation|upregulation of relaxation of smooth muscle|upregulation of smooth muscle relaxation http://purl.obolibrary.org/obo/GO_1901082 GO:1901083 biolink:BiologicalProcess pyrrolizidine alkaloid metabolic process The chemical reactions and pathways involving pyrrolizidine alkaloid. go.json pyrrolizidine alkaloid metabolism http://purl.obolibrary.org/obo/GO_1901083 GO:1901080 biolink:BiologicalProcess regulation of relaxation of smooth muscle Any process that modulates the frequency, rate or extent of relaxation of smooth muscle. go.json regulation of smooth muscle relaxation http://purl.obolibrary.org/obo/GO_1901080 GO:1901081 biolink:BiologicalProcess negative regulation of relaxation of smooth muscle Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle. go.json down regulation of relaxation of smooth muscle|down regulation of smooth muscle relaxation|down-regulation of relaxation of smooth muscle|down-regulation of smooth muscle relaxation|downregulation of relaxation of smooth muscle|downregulation of smooth muscle relaxation|inhibition of relaxation of smooth muscle|inhibition of smooth muscle relaxation|negative regulation of smooth muscle relaxation http://purl.obolibrary.org/obo/GO_1901081 GO:0012505 biolink:CellularComponent endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. Wikipedia:Endomembrane_system go.json http://purl.obolibrary.org/obo/GO_0012505 goslim_candida|goslim_flybase_ribbon|goslim_yeast GO:0012506 biolink:CellularComponent vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell. NIF_Subcellular:sao1153182838 go.json http://purl.obolibrary.org/obo/GO_0012506 GO:0012503 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0012503 GO:0012504 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0012504 GO:0012509 biolink:CellularComponent inter-Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances within the Golgi. go.json inter-Golgi transport constitutive secretory pathway transport vesicle membrane http://purl.obolibrary.org/obo/GO_0012509 GO:1901088 biolink:BiologicalProcess benzylpenicillin biosynthetic process The chemical reactions and pathways resulting in the formation of benzylpenicillin. go.json benzylpenicillin anabolism|benzylpenicillin biosynthesis|benzylpenicillin formation|benzylpenicillin synthesis|penicillin G anabolism|penicillin G biosynthesis|penicillin G formation|penicillin G synthesis http://purl.obolibrary.org/obo/GO_1901088 GO:0012507 biolink:CellularComponent ER to Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. go.json COPII coated vesicle membrane|ER to Golgi constitutive secretory pathway transport vesicle membrane|ER-Golgi transport vesicle membrane|endoplasmic reticulum to Golgi transport vesicle membrane|endoplasmic reticulum-Golgi transport vesicle membrane http://purl.obolibrary.org/obo/GO_0012507 GO:0012508 biolink:CellularComponent Golgi to ER transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER. go.json Golgi to ER constitutive secretory pathway transport vesicle membrane|Golgi to endoplasmic reticulum transport vesicle membrane|Golgi-ER transport vesicle membrane|Golgi-endoplasmic reticulum transport vesicle membrane http://purl.obolibrary.org/obo/GO_0012508 GO:1901089 biolink:BiologicalProcess acetate ester metabolic process involved in fermentation Any acetate ester metabolic process that is involved in fermentation. go.json acetate ester metabolic process during fermentation http://purl.obolibrary.org/obo/GO_1901089 GO:1901097 biolink:BiologicalProcess negative regulation of autophagosome maturation Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation. go.json down regulation of amphisome-lysosome fusion|down regulation of autolysosome formation|down regulation of autophagic vacuole fusion|down regulation of autophagic vacuole maturation|down regulation of autophagosome maturation|down regulation of fusion of autophagosome with lysosome|down-regulation of amphisome-lysosome fusion|down-regulation of autolysosome formation|down-regulation of autophagic vacuole fusion|down-regulation of autophagic vacuole maturation|down-regulation of autophagosome maturation|down-regulation of fusion of autophagosome with lysosome|downregulation of amphisome-lysosome fusion|downregulation of autolysosome formation|downregulation of autophagic vacuole fusion|downregulation of autophagic vacuole maturation|downregulation of autophagosome maturation|downregulation of fusion of autophagosome with lysosome|inhibition of amphisome-lysosome fusion|inhibition of autolysosome formation|inhibition of autophagic vacuole fusion|inhibition of autophagic vacuole maturation|inhibition of autophagosome maturation|inhibition of fusion of autophagosome with lysosome|negative regulation of amphisome-lysosome fusion|negative regulation of autolysosome formation|negative regulation of autophagic vacuole fusion|negative regulation of autophagosome fusion|negative regulation of fusion of autophagosome with lysosome http://purl.obolibrary.org/obo/GO_1901097 GO:1901098 biolink:BiologicalProcess positive regulation of autophagosome maturation Any process that activates or increases the frequency, rate or extent of autophagosome maturation. go.json activation of amphisome-lysosome fusion|activation of autolysosome formation|activation of autophagic vacuole fusion|activation of autophagic vacuole maturation|activation of autophagosome maturation|activation of fusion of autophagosome with lysosome|positive regulation of amphisome-lysosome fusion|positive regulation of autolysosome formation|positive regulation of autophagic vacuole fusion|positive regulation of autophagosome fusion|positive regulation of fusion of autophagosome with lysosome|up regulation of amphisome-lysosome fusion|up regulation of autolysosome formation|up regulation of autophagic vacuole fusion|up regulation of autophagic vacuole maturation|up regulation of autophagosome maturation|up regulation of fusion of autophagosome with lysosome|up-regulation of amphisome-lysosome fusion|up-regulation of autolysosome formation|up-regulation of autophagic vacuole fusion|up-regulation of autophagic vacuole maturation|up-regulation of autophagosome maturation|up-regulation of fusion of autophagosome with lysosome|upregulation of amphisome-lysosome fusion|upregulation of autolysosome formation|upregulation of autophagic vacuole fusion|upregulation of autophagic vacuole maturation|upregulation of autophagosome maturation|upregulation of fusion of autophagosome with lysosome http://purl.obolibrary.org/obo/GO_1901098 GO:1901095 biolink:BiologicalProcess positive regulation of protein homotetramerization Any process that activates or increases the frequency, rate or extent of protein homotetramerization. go.json activation of protein homotetramer assembly|activation of protein homotetramer biosynthesis|activation of protein homotetramer biosynthetic process|activation of protein homotetramer formation|activation of protein homotetramerization|positive regulation of protein homotetramer assembly|positive regulation of protein homotetramer biosynthesis|positive regulation of protein homotetramer biosynthetic process|positive regulation of protein homotetramer formation|up regulation of protein homotetramer assembly|up regulation of protein homotetramer biosynthesis|up regulation of protein homotetramer biosynthetic process|up regulation of protein homotetramer formation|up regulation of protein homotetramerization|up-regulation of protein homotetramer assembly|up-regulation of protein homotetramer biosynthesis|up-regulation of protein homotetramer biosynthetic process|up-regulation of protein homotetramer formation|up-regulation of protein homotetramerization|upregulation of protein homotetramer assembly|upregulation of protein homotetramer biosynthesis|upregulation of protein homotetramer biosynthetic process|upregulation of protein homotetramer formation|upregulation of protein homotetramerization http://purl.obolibrary.org/obo/GO_1901095 GO:1901096 biolink:BiologicalProcess regulation of autophagosome maturation Any process that modulates the frequency, rate or extent of autophagosome maturation. go.json regulation of amphisome-lysosome fusion|regulation of autolysosome formation|regulation of autophagic vacuole fusion|regulation of autophagosome fusion|regulation of fusion of autophagosome with lysosome http://purl.obolibrary.org/obo/GO_1901096 GO:0012501 biolink:BiologicalProcess programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. Wikipedia:Programmed_cell_death go.json PCD|RCD|caspase-independent apoptosis|caspase-independent cell death|non-apoptotic programmed cell death|nonapoptotic programmed cell death|regulated cell death http://purl.obolibrary.org/obo/GO_0012501 goslim_agr|goslim_chembl|goslim_drosophila|goslim_generic|goslim_mouse|goslim_plant|prokaryote_subset GO:1901093 biolink:BiologicalProcess regulation of protein homotetramerization Any process that modulates the frequency, rate or extent of protein homotetramerization. go.json regulation of protein homotetramer assembly|regulation of protein homotetramer biosynthesis|regulation of protein homotetramer biosynthetic process|regulation of protein homotetramer formation http://purl.obolibrary.org/obo/GO_1901093 GO:1901094 biolink:BiologicalProcess negative regulation of protein homotetramerization Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization. go.json down regulation of protein homotetramer assembly|down regulation of protein homotetramer biosynthesis|down regulation of protein homotetramer biosynthetic process|down regulation of protein homotetramer formation|down regulation of protein homotetramerization|down-regulation of protein homotetramer assembly|down-regulation of protein homotetramer biosynthesis|down-regulation of protein homotetramer biosynthetic process|down-regulation of protein homotetramer formation|down-regulation of protein homotetramerization|downregulation of protein homotetramer assembly|downregulation of protein homotetramer biosynthesis|downregulation of protein homotetramer biosynthetic process|downregulation of protein homotetramer formation|downregulation of protein homotetramerization|inhibition of protein homotetramer assembly|inhibition of protein homotetramer biosynthesis|inhibition of protein homotetramer biosynthetic process|inhibition of protein homotetramer formation|inhibition of protein homotetramerization|negative regulation of protein homotetramer assembly|negative regulation of protein homotetramer biosynthesis|negative regulation of protein homotetramer biosynthetic process|negative regulation of protein homotetramer formation http://purl.obolibrary.org/obo/GO_1901094 GO:0012502 biolink:BiologicalProcess induction of programmed cell death A process which directly activates any of the steps required for programmed cell death. go.json induction of non-apoptotic programmed cell death|induction of nonapoptotic programmed cell death http://purl.obolibrary.org/obo/GO_0012502 GO:1901091 biolink:BiologicalProcess negative regulation of protein tetramerization Any process that stops, prevents or reduces the frequency, rate or extent of protein tetramerization. go.json down regulation of protein tetramer assembly|down regulation of protein tetramer biosynthesis|down regulation of protein tetramer biosynthetic process|down regulation of protein tetramer formation|down regulation of protein tetramerization|down-regulation of protein tetramer assembly|down-regulation of protein tetramer biosynthesis|down-regulation of protein tetramer biosynthetic process|down-regulation of protein tetramer formation|down-regulation of protein tetramerization|downregulation of protein tetramer assembly|downregulation of protein tetramer biosynthesis|downregulation of protein tetramer biosynthetic process|downregulation of protein tetramer formation|downregulation of protein tetramerization|inhibition of protein tetramer assembly|inhibition of protein tetramer biosynthesis|inhibition of protein tetramer biosynthetic process|inhibition of protein tetramer formation|inhibition of protein tetramerization|negative regulation of protein tetramer assembly|negative regulation of protein tetramer biosynthesis|negative regulation of protein tetramer biosynthetic process|negative regulation of protein tetramer formation http://purl.obolibrary.org/obo/GO_1901091 GO:1901092 biolink:BiologicalProcess positive regulation of protein tetramerization Any process that activates or increases the frequency, rate or extent of protein tetramerization. go.json activation of protein tetramer assembly|activation of protein tetramer biosynthesis|activation of protein tetramer biosynthetic process|activation of protein tetramer formation|activation of protein tetramerization|positive regulation of protein tetramer assembly|positive regulation of protein tetramer biosynthesis|positive regulation of protein tetramer biosynthetic process|positive regulation of protein tetramer formation|up regulation of protein tetramer assembly|up regulation of protein tetramer biosynthesis|up regulation of protein tetramer biosynthetic process|up regulation of protein tetramer formation|up regulation of protein tetramerization|up-regulation of protein tetramer assembly|up-regulation of protein tetramer biosynthesis|up-regulation of protein tetramer biosynthetic process|up-regulation of protein tetramer formation|up-regulation of protein tetramerization|upregulation of protein tetramer assembly|upregulation of protein tetramer biosynthesis|upregulation of protein tetramer biosynthetic process|upregulation of protein tetramer formation|upregulation of protein tetramerization http://purl.obolibrary.org/obo/GO_1901092 GO:1901090 biolink:BiologicalProcess regulation of protein tetramerization Any process that modulates the frequency, rate or extent of protein tetramerization. go.json regulation of protein tetramer assembly|regulation of protein tetramer biosynthesis|regulation of protein tetramer biosynthetic process|regulation of protein tetramer formation http://purl.obolibrary.org/obo/GO_1901090 GO:1901099 biolink:BiologicalProcess negative regulation of signal transduction in absence of ligand Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. go.json down regulation of basal signaling|down regulation of non-classical signal transduction|down regulation of signal transduction in absence of agonist|down regulation of signal transduction in absence of ligand|down-regulation of basal signaling|down-regulation of non-classical signal transduction|down-regulation of signal transduction in absence of agonist|down-regulation of signal transduction in absence of ligand|downregulation of basal signaling|downregulation of non-classical signal transduction|downregulation of signal transduction in absence of agonist|downregulation of signal transduction in absence of ligand|inhibition of signal transduction in absence of ligand|negative regulation of non-classical signal transduction|negative regulation of signal transduction in absence of agonist http://purl.obolibrary.org/obo/GO_1901099 GO:0012510 biolink:CellularComponent trans-Golgi network transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. go.json TGN transport vesicle membrane|trans-Golgi network constitutive secretory pathway transport vesicle membrane http://purl.obolibrary.org/obo/GO_0012510 GO:0012511 biolink:CellularComponent monolayer-surrounded lipid storage body A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. Wikipedia:Oil_body go.json oil body|oilbody|oleosome|spherosome http://purl.obolibrary.org/obo/GO_0012511 GO:0061440 biolink:BiologicalProcess kidney vasculature development The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061440 GO:0061441 biolink:BiologicalProcess renal artery morphogenesis The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood. go.json http://purl.obolibrary.org/obo/GO_0061441 GO:0061442 biolink:BiologicalProcess cardiac muscle cell fate determination The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. go.json http://purl.obolibrary.org/obo/GO_0061442 GO:0036475 biolink:BiologicalProcess obsolete neuron death in response to oxidative stress OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus. go.json neuronal cell death in response to oxidative stress|oxidative stress-induced neuron death True http://purl.obolibrary.org/obo/GO_0036475 GO:0061443 biolink:BiologicalProcess endocardial cushion cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell. go.json http://purl.obolibrary.org/obo/GO_0061443 GO:0036476 biolink:BiologicalProcess obsolete neuron death in response to hydrogen peroxide OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2). go.json hydrogen peroxide-induced neuron death|neuron death in response to H2O2|neuronal cell death in response to hydrogen peroxide True http://purl.obolibrary.org/obo/GO_0036476 GO:0061444 biolink:BiologicalProcess endocardial cushion cell development The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0061444 GO:0036477 biolink:CellularComponent somatodendritic compartment The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. go.json http://purl.obolibrary.org/obo/GO_0036477 GO:0061445 biolink:BiologicalProcess endocardial cushion cell fate commitment The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell. go.json http://purl.obolibrary.org/obo/GO_0061445 GO:0036478 biolink:MolecularActivity L-dopa decarboxylase activator activity Interacts with and increases L-dopa decarboxylase activity. go.json DDC activator activity http://purl.obolibrary.org/obo/GO_0036478 GO:0061446 biolink:BiologicalProcess endocardial cushion cell fate determination The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. go.json http://purl.obolibrary.org/obo/GO_0061446 GO:0036479 biolink:MolecularActivity peroxidase inhibitor activity Binds to and stops, prevents or reduces the activity of peroxidase. go.json http://purl.obolibrary.org/obo/GO_0036479 GO:0061447 biolink:BiologicalProcess endocardial cushion cell fate specification The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. go.json http://purl.obolibrary.org/obo/GO_0061447 GO:0061448 biolink:BiologicalProcess connective tissue development The progression of a connective tissue over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061448 GO:0061449 biolink:BiologicalProcess olfactory bulb tufted cell development The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0061449 GO:0036470 biolink:MolecularActivity tyrosine 3-monooxygenase activator activity Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase). go.json TH activator activity|tyrosine hydroxylase activator activity http://purl.obolibrary.org/obo/GO_0036470 GO:0036471 biolink:BiologicalProcess cellular response to glyoxal Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus. go.json http://purl.obolibrary.org/obo/GO_0036471 GO:0036472 biolink:BiologicalProcess obsolete suppression by virus of host protein-protein interaction OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins. go.json suppression by virus of host protein binding|suppression by virus of host protein interaction|suppression by virus of host protein:protein binding|suppression by virus of host protein:protein interaction True http://purl.obolibrary.org/obo/GO_0036472 GO:0036473 biolink:BiologicalProcess obsolete cell death in response to oxidative stress OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. go.json True http://purl.obolibrary.org/obo/GO_0036473 GO:0036474 biolink:BiologicalProcess obsolete cell death in response to hydrogen peroxide OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2). go.json cell death in response to H2O2|hydrogen peroxide-mediated cell death True http://purl.obolibrary.org/obo/GO_0036474 GO:0061430 biolink:BiologicalProcess bone trabecula morphogenesis The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. go.json http://purl.obolibrary.org/obo/GO_0061430 GO:0061431 biolink:BiologicalProcess cellular response to methionine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus. go.json http://purl.obolibrary.org/obo/GO_0061431 GO:0036464 biolink:CellularComponent cytoplasmic ribonucleoprotein granule A ribonucleoprotein granule located in the cytoplasm. go.json Staufen granule http://purl.obolibrary.org/obo/GO_0036464 GO:0036465 biolink:BiologicalProcess synaptic vesicle recycling The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. go.json kiss-and-run synaptic vesicle recycling|kiss-and-stay synaptic vesicle recycling http://purl.obolibrary.org/obo/GO_0036465 GO:0061432 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to methionine OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061432 GO:0061433 biolink:BiologicalProcess cellular response to caloric restriction Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake. go.json http://purl.obolibrary.org/obo/GO_0061433 GO:0036466 biolink:BiologicalProcess synaptic vesicle recycling via endosome Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate. go.json recycling endosome localization within postsynapse http://purl.obolibrary.org/obo/GO_0036466 goslim_synapse GO:0036467 biolink:MolecularActivity 5-hydroxy-L-tryptophan decarboxylase activity Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. RHEA:18533 go.json 5-hydroxytryptophan decarboxylase activity http://purl.obolibrary.org/obo/GO_0036467 GO:0061434 biolink:BiologicalProcess obsolete regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061434 GO:0061435 biolink:BiologicalProcess positive regulation of transcription from a mobile element promoter Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter. go.json http://purl.obolibrary.org/obo/GO_0061435 GO:0036468 biolink:MolecularActivity L-dopa decarboxylase activity Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. RHEA:12272 go.json 4-dihydroxyl-L-phenylalanine decarboxylase activity|DDC activity|DOPA decarboxylase activity http://purl.obolibrary.org/obo/GO_0036468 GO:0061436 biolink:BiologicalProcess establishment of skin barrier Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. go.json epithelial barrier development|establishment of epithelial barrier|skin barrier development http://purl.obolibrary.org/obo/GO_0061436 GO:0036469 biolink:MolecularActivity L-tryptophan decarboxylase activity Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine. EC:4.1.1.105|RHEA:30339 go.json http://purl.obolibrary.org/obo/GO_0036469 GO:0061437 biolink:BiologicalProcess renal system vasculature development The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061437 GO:0061438 biolink:BiologicalProcess renal system vasculature morphogenesis The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form. go.json http://purl.obolibrary.org/obo/GO_0061438 GO:0061439 biolink:BiologicalProcess kidney vasculature morphogenesis The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form. go.json http://purl.obolibrary.org/obo/GO_0061439 GO:0036460 biolink:BiologicalProcess cellular response to cell envelope stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope. go.json envelope stress response http://purl.obolibrary.org/obo/GO_0036460 GO:0036461 biolink:MolecularActivity BLOC-2 complex binding Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. go.json http://purl.obolibrary.org/obo/GO_0036461 GO:0036462 biolink:BiologicalProcess TRAIL-activated apoptotic signaling pathway An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface. go.json TRAIL-activated extrinsic apoptotic signaling pathway|TRAIL-induced apoptotic signaling pathway|tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_0036462 GO:0036463 biolink:MolecularActivity TRAIL receptor activity Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death. go.json tumor necrosis factor-related apoptosis-inducing ligand receptor http://purl.obolibrary.org/obo/GO_0036463 GO:2000005 biolink:BiologicalProcess negative regulation of metanephric S-shaped body morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000005 GO:2000006 biolink:BiologicalProcess regulation of metanephric comma-shaped body morphogenesis Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000006 GO:2000007 biolink:BiologicalProcess negative regulation of metanephric comma-shaped body morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000007 GO:2000008 biolink:BiologicalProcess regulation of protein localization to cell surface Any process that modulates the frequency, rate or extent of protein localization to the cell surface. go.json regulation of protein localisation at cell surface|regulation of protein localization at cell surface http://purl.obolibrary.org/obo/GO_2000008 GO:0061460 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061460 GO:2000009 biolink:BiologicalProcess negative regulation of protein localization to cell surface Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface. go.json negative regulation of protein localisation at cell surface|negative regulation of protein localization at cell surface http://purl.obolibrary.org/obo/GO_2000009 GO:0061461 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061461 GO:0061462 biolink:BiologicalProcess protein localization to lysosome A process in which a protein is transported to, or maintained in, a location within a lysosome. go.json http://purl.obolibrary.org/obo/GO_0061462 GO:0061463 biolink:MolecularActivity O-acetyl-ADP-ribose deacetylase activity Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. go.json http://purl.obolibrary.org/obo/GO_0061463 GO:0061464 biolink:CellularComponent obsolete plasma membrane part of cell-substrate junction OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell-substrate junction. go.json True http://purl.obolibrary.org/obo/GO_0061464 GO:0036453 biolink:BiologicalProcess transitive RNA interference An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence. go.json transitive RNAi http://purl.obolibrary.org/obo/GO_0036453 GO:0061465 biolink:CellularComponent obsolete plasma membrane part of hemidesmosome OBSOLETE. The part of the plasma membrane that contributes to the structure of a hemidesmosome. go.json True http://purl.obolibrary.org/obo/GO_0061465 GO:0036454 biolink:CellularComponent growth factor complex A protein complex that has growth factor activity. go.json http://purl.obolibrary.org/obo/GO_0036454 GO:0036455 biolink:MolecularActivity iron-sulfur transferase activity Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor). Reactome:R-HSA-2564828 go.json Fe-S transferase activity http://purl.obolibrary.org/obo/GO_0036455 GO:0061466 biolink:CellularComponent obsolete plasma membrane part of cell junction OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell junction. go.json True http://purl.obolibrary.org/obo/GO_0061466 GO:0036456 biolink:MolecularActivity L-methionine-(S)-S-oxide reductase activity Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O. RHEA:19995 go.json http://purl.obolibrary.org/obo/GO_0036456 GO:0061467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061467 GO:0061468 biolink:CellularComponent karyomere A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division. go.json http://purl.obolibrary.org/obo/GO_0061468 GO:0036457 biolink:CellularComponent keratohyalin granule A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope. go.json http://purl.obolibrary.org/obo/GO_0036457 GO:2000001 biolink:BiologicalProcess regulation of DNA damage checkpoint Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. go.json regulation of DNA damage response, signal transduction resulting in cell cycle arrest http://purl.obolibrary.org/obo/GO_2000001 GO:0036458 biolink:MolecularActivity hepatocyte growth factor binding Binding to a hepatocyte growth factor. go.json HGF binding http://purl.obolibrary.org/obo/GO_0036458 GO:0061469 biolink:BiologicalProcess regulation of type B pancreatic cell proliferation Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0061469 GO:2000002 biolink:BiologicalProcess negative regulation of DNA damage checkpoint Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint. go.json negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest http://purl.obolibrary.org/obo/GO_2000002 GO:2000003 biolink:BiologicalProcess positive regulation of DNA damage checkpoint Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint. go.json positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest http://purl.obolibrary.org/obo/GO_2000003 GO:0036459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036459 GO:2000004 biolink:BiologicalProcess regulation of metanephric S-shaped body morphogenesis Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000004 GO:0036450 biolink:BiologicalProcess polyuridylation-dependent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end. go.json uridylation-dependent decapping of nuclear-transcribed mRNA http://purl.obolibrary.org/obo/GO_0036450 GO:0036451 biolink:BiologicalProcess cap mRNA methylation Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA. go.json http://purl.obolibrary.org/obo/GO_0036451 GO:0036452 biolink:CellularComponent ESCRT complex An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes. Wikipedia:ESCRT go.json endosomal sorting complex required for transport http://purl.obolibrary.org/obo/GO_0036452 GO:2000016 biolink:BiologicalProcess negative regulation of determination of dorsal identity Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity. go.json negative regulation of determination of adaxial identity http://purl.obolibrary.org/obo/GO_2000016 GO:2000017 biolink:BiologicalProcess positive regulation of determination of dorsal identity Any process that activates or increases the frequency, rate or extent of determination of dorsal identity. go.json positive regulation of determination of adaxial identity http://purl.obolibrary.org/obo/GO_2000017 GO:2000018 biolink:BiologicalProcess regulation of male gonad development Any process that modulates the frequency, rate or extent of male gonad development. go.json regulation of testicular development|regulation of testis development http://purl.obolibrary.org/obo/GO_2000018 GO:2000019 biolink:BiologicalProcess negative regulation of male gonad development Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development. go.json negative regulation of testicular development|negative regulation of testis development http://purl.obolibrary.org/obo/GO_2000019 GO:0061450 biolink:BiologicalProcess trophoblast cell migration Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. go.json http://purl.obolibrary.org/obo/GO_0061450 GO:0061451 biolink:BiologicalProcess retrotrapezoid nucleus development The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration. go.json http://purl.obolibrary.org/obo/GO_0061451 GO:0061452 biolink:BiologicalProcess retrotrapezoid nucleus neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus. go.json http://purl.obolibrary.org/obo/GO_0061452 GO:0061453 biolink:BiologicalProcess interstitial cell of Cajal differentiation The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. go.json ICC differentiation http://purl.obolibrary.org/obo/GO_0061453 GO:0036442 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036442 GO:0061454 biolink:BiologicalProcess release of sequestered calcium ion into cytosol by Golgi The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol. go.json Golgi calcium ion export http://purl.obolibrary.org/obo/GO_0061454 GO:0036443 biolink:MolecularActivity dermatan 6-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate. KEGG_REACTION:R07288 go.json http://purl.obolibrary.org/obo/GO_0036443 GO:2000010 biolink:BiologicalProcess positive regulation of protein localization to cell surface Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. go.json positive regulation of protein localisation at cell surface|positive regulation of protein localization at cell surface http://purl.obolibrary.org/obo/GO_2000010 GO:0036444 biolink:BiologicalProcess calcium import into the mitochondrion A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix. go.json calcium ion import into mitochondrion|calcium ion transmembrane import into mitochondrion|mitochondrial calcium ion import|mitochondrial calcium uptake http://purl.obolibrary.org/obo/GO_0036444 GO:0061455 biolink:CellularComponent obsolete integral component of muscle cell projection membrane OBSOLETE. The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to muscle cell projection membrane True http://purl.obolibrary.org/obo/GO_0061455 GO:0061456 biolink:BiologicalProcess mesenchymal stem cell migration involved in uteric bud morphogenesis The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0061456 GO:2000011 biolink:BiologicalProcess regulation of adaxial/abaxial pattern formation Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation. go.json regulation of adaxial/abaxial pattern specification http://purl.obolibrary.org/obo/GO_2000011 GO:0036445 biolink:BiologicalProcess neuronal stem cell division The self-renewing division of a neuronal stem cell. go.json NSC division http://purl.obolibrary.org/obo/GO_0036445 GO:0061457 biolink:BiologicalProcess mesonephric cell migration involved in male gonad development The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development. go.json http://purl.obolibrary.org/obo/GO_0061457 GO:0036446 biolink:BiologicalProcess myofibroblast differentiation The process in which an undifferentiated cell acquires the features of a myofibroblast cell. go.json myofibroblast cell differentiation http://purl.obolibrary.org/obo/GO_0036446 GO:2000012 biolink:BiologicalProcess regulation of auxin polar transport Any process that modulates the frequency, rate or extent of auxin polar transport. go.json http://purl.obolibrary.org/obo/GO_2000012 GO:2000013 biolink:BiologicalProcess regulation of arginine biosynthetic process via ornithine Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine. go.json regulation of arginine anabolism via ornithine|regulation of arginine formation via ornithine|regulation of arginine synthesis via ornithine http://purl.obolibrary.org/obo/GO_2000013 GO:0061458 biolink:BiologicalProcess reproductive system development The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. go.json http://purl.obolibrary.org/obo/GO_0061458 GO:0036447 biolink:BiologicalProcess cellular response to sugar-phosphate stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate. go.json cellular response to presence of non-metabolizable sugars http://purl.obolibrary.org/obo/GO_0036447 GO:0061459 biolink:MolecularActivity L-arginine transmembrane transporter activity Enables the transfer of L-arginine from one side of a membrane to the other. RHEA:32143 go.json ATP-dependent L-arginine transmembrane transporter activity|ATPase-coupled L-arginine transmembrane transporter activity|L-arginine transporter activity|L-arginine-importing ATPase activity|arginine permease activity|arginine porter activity|arginine transmembrane transporter activity|arginine-importing ATPase activity|histidine/arginine/lysine/ornithine porter activity http://purl.obolibrary.org/obo/GO_0061459 GO:0036448 biolink:BiologicalProcess cellular response to glucose-phosphate stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate. go.json http://purl.obolibrary.org/obo/GO_0036448 GO:2000014 biolink:BiologicalProcess regulation of endosperm development Any process that modulates the frequency, rate or extent of endosperm development. go.json http://purl.obolibrary.org/obo/GO_2000014 GO:0036449 biolink:CellularComponent microtubule minus-end The end of a microtubule that does not preferentially grow (polymerize). go.json microtubule minus end http://purl.obolibrary.org/obo/GO_0036449 GO:2000015 biolink:BiologicalProcess regulation of determination of dorsal identity Any process that modulates the frequency, rate or extent of determination of dorsal identity. go.json regulation of determination of adaxial identity http://purl.obolibrary.org/obo/GO_2000015 GO:0036440 biolink:MolecularActivity citrate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. EC:2.3.3.16|KEGG_REACTION:R00351|MetaCyc:CITSYN-RXN|RHEA:16845 go.json http://purl.obolibrary.org/obo/GO_0036440 GO:0036441 biolink:MolecularActivity 2-dehydropantolactone reductase activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. KEGG_REACTION:R03155|RHEA:18981 go.json http://purl.obolibrary.org/obo/GO_0036441 GO:1901008 biolink:BiologicalProcess obsolete (S)-scoulerine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of (S)-scoulerine. go.json (S)-scoulerine breakdown|(S)-scoulerine catabolism|(S)-scoulerine degradation True http://purl.obolibrary.org/obo/GO_1901008 GO:1901009 biolink:BiologicalProcess (S)-scoulerine biosynthetic process The chemical reactions and pathways resulting in the formation of (S)-scoulerine. go.json (S)-scoulerine anabolism|(S)-scoulerine biosynthesis|(S)-scoulerine formation|(S)-scoulerine synthesis http://purl.obolibrary.org/obo/GO_1901009 GO:1901006 biolink:BiologicalProcess ubiquinone-6 biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone-6. go.json ubiquinone-6 anabolism|ubiquinone-6 biosynthesis|ubiquinone-6 formation|ubiquinone-6 synthesis http://purl.obolibrary.org/obo/GO_1901006 GO:0036439 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036439 GO:1901007 biolink:BiologicalProcess (S)-scoulerine metabolic process The chemical reactions and pathways involving (S)-scoulerine. go.json (S)-scoulerine metabolism http://purl.obolibrary.org/obo/GO_1901007 GO:1901004 biolink:BiologicalProcess ubiquinone-6 metabolic process The chemical reactions and pathways involving ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2. go.json coenzyme Q6 metabolic process|coenzyme Q6 metabolism|ubiquinone-6 metabolism http://purl.obolibrary.org/obo/GO_1901004 GO:0061480 biolink:BiologicalProcess response to asparaginase Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus. go.json http://purl.obolibrary.org/obo/GO_0061480 GO:1901005 biolink:BiologicalProcess ubiquinone-6 catabolic process The chemical reactions and pathways resulting in the breakdown of ubiquinone-6. go.json ubiquinone-6 breakdown|ubiquinone-6 catabolism|ubiquinone-6 degradation http://purl.obolibrary.org/obo/GO_1901005 GO:0061481 biolink:BiologicalProcess response to TNF agonist Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus. go.json http://purl.obolibrary.org/obo/GO_0061481 GO:1901002 biolink:BiologicalProcess positive regulation of response to salt stress Any process that activates or increases the frequency, rate or extent of response to salt stress. go.json activation of response to ionic osmotic stress|activation of response to salt stress|activation of salinity response|positive regulation of response to ionic osmotic stress|positive regulation of salinity response|up regulation of response to ionic osmotic stress|up regulation of response to salt stress|up regulation of salinity response|up-regulation of response to ionic osmotic stress|up-regulation of response to salt stress|up-regulation of salinity response|upregulation of response to ionic osmotic stress|upregulation of response to salt stress|upregulation of salinity response http://purl.obolibrary.org/obo/GO_1901002 GO:0061482 biolink:BiologicalProcess response to irinotecan Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus. go.json http://purl.obolibrary.org/obo/GO_0061482 GO:1901003 biolink:BiologicalProcess negative regulation of fermentation Any process that stops, prevents or reduces the frequency, rate or extent of fermentation. go.json down regulation of fermentation|down-regulation of fermentation|downregulation of fermentation|inhibition of fermentation http://purl.obolibrary.org/obo/GO_1901003 GO:0061483 biolink:MolecularActivity sulfinylpropanyl adenylate synthase Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate. go.json SPA synthase http://purl.obolibrary.org/obo/GO_0061483 GO:1901000 biolink:BiologicalProcess regulation of response to salt stress Any process that modulates the frequency, rate or extent of response to salt stress. go.json regulation of response to ionic osmotic stress|regulation of salinity response http://purl.obolibrary.org/obo/GO_1901000 GO:0061484 biolink:BiologicalProcess hematopoietic stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. go.json http://purl.obolibrary.org/obo/GO_0061484 GO:1901001 biolink:BiologicalProcess negative regulation of response to salt stress Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress. go.json down regulation of response to ionic osmotic stress|down regulation of response to salt stress|down regulation of salinity response|down-regulation of response to ionic osmotic stress|down-regulation of response to salt stress|down-regulation of salinity response|downregulation of response to ionic osmotic stress|downregulation of response to salt stress|downregulation of salinity response|inhibition of response to ionic osmotic stress|inhibition of response to salt stress|inhibition of salinity response|negative regulation of response to ionic osmotic stress|negative regulation of salinity response http://purl.obolibrary.org/obo/GO_1901001 GO:0061485 biolink:BiologicalProcess memory T cell proliferation The expansion of a memory T cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0061485 GO:0036431 biolink:MolecularActivity dCMP kinase activity Catalysis of the reaction: ATP + dCMP = ADP + dCDP. KEGG_REACTION:R01665|MetaCyc:RXN-7913|RHEA:25094 go.json ATP:dCMP phosphotransferase activity http://purl.obolibrary.org/obo/GO_0036431 GO:0061486 biolink:MolecularActivity high-affinity fructose transmembrane transporter activity Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity fructose transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0061486 GO:0036432 biolink:MolecularActivity all-trans undecaprenol kinase activity Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+. RHEA:23752 go.json http://purl.obolibrary.org/obo/GO_0036432 GO:0061487 biolink:BiologicalProcess obsolete DNA replication initiation from late origin OBSOLETE. The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase. go.json late replication origin firing True http://purl.obolibrary.org/obo/GO_0061487 GO:1901010 biolink:BiologicalProcess (S)-reticuline metabolic process The chemical reactions and pathways involving (S)-reticuline. go.json (S)-reticuline metabolism http://purl.obolibrary.org/obo/GO_1901010 GO:0036433 biolink:MolecularActivity di-trans, poly-cis-undecaprenol kinase activity Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+. KEGG_REACTION:R05626|MetaCyc:UNDECAPRENOL-KINASE-RXN|RHEA:28122 go.json ditrans,polycis-undecaprenol kinase activity http://purl.obolibrary.org/obo/GO_0036433 GO:0061488 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061488 GO:0036434 biolink:MolecularActivity nitronate monooxygenase (FMN-linked) activity Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite. KEGG_REACTION:R00025|RHEA:26458 go.json http://purl.obolibrary.org/obo/GO_0036434 GO:0061489 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061489 GO:0036435 biolink:MolecularActivity K48-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein. Reactome:R-HSA-5683077 go.json http://purl.obolibrary.org/obo/GO_0036435 GO:0036436 biolink:CellularComponent Isw1a complex An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p. go.json http://purl.obolibrary.org/obo/GO_0036436 GO:0036437 biolink:CellularComponent Isw1b complex An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p. go.json http://purl.obolibrary.org/obo/GO_0036437 GO:0036438 biolink:BiologicalProcess maintenance of lens transparency A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. go.json maintenance of ocular lens transparency|preservation of lens transparency http://purl.obolibrary.org/obo/GO_0036438 GO:0036430 biolink:MolecularActivity CMP kinase activity Catalysis of the reaction: ATP + CMP = ADP + CDP. KEGG_REACTION:R00512|MetaCyc:RXN-11832|RHEA:11600 go.json http://purl.obolibrary.org/obo/GO_0036430 GO:1901019 biolink:BiologicalProcess regulation of calcium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. go.json http://purl.obolibrary.org/obo/GO_1901019 gocheck_do_not_annotate GO:1901017 biolink:BiologicalProcess negative regulation of potassium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. go.json down regulation of potassium ion transmembrane transporter activity|down regulation of potassium transporter activity|down-regulation of potassium ion transmembrane transporter activity|down-regulation of potassium transporter activity|downregulation of potassium ion transmembrane transporter activity|downregulation of potassium transporter activity|inhibition of potassium ion transmembrane transporter activity|inhibition of potassium transporter activity|negative regulation of potassium transporter activity http://purl.obolibrary.org/obo/GO_1901017 gocheck_do_not_annotate GO:0036428 biolink:MolecularActivity adenosylcobinamide kinase (GTP-specific) activity Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+. KEGG_REACTION:R06558|MetaCyc:RXN-14063|RHEA:15765 go.json http://purl.obolibrary.org/obo/GO_0036428 GO:1901018 biolink:BiologicalProcess positive regulation of potassium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. go.json activation of potassium ion transmembrane transporter activity|activation of potassium transporter activity|positive regulation of potassium transporter activity|up regulation of potassium ion transmembrane transporter activity|up regulation of potassium transporter activity|up-regulation of potassium ion transmembrane transporter activity|up-regulation of potassium transporter activity|upregulation of potassium ion transmembrane transporter activity|upregulation of potassium transporter activity http://purl.obolibrary.org/obo/GO_1901018 gocheck_do_not_annotate GO:0036429 biolink:MolecularActivity adenosylcobinamide kinase (ATP-specific) activity Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+. KEGG_REACTION:R05221|MetaCyc:COBINAMIDEKIN-RXN|RHEA:15769 go.json http://purl.obolibrary.org/obo/GO_0036429 GO:1901015 biolink:BiologicalProcess 3alpha(S)-strictosidine biosynthetic process The chemical reactions and pathways resulting in the formation of 3alpha(S)-strictosidine. go.json 3alpha(S)-strictosidine anabolism|3alpha(S)-strictosidine biosynthesis|3alpha(S)-strictosidine formation|3alpha(S)-strictosidine metabolic process|3alpha(S)-strictosidine metabolism|3alpha(S)-strictosidine synthesis http://purl.obolibrary.org/obo/GO_1901015 GO:0061470 biolink:BiologicalProcess T follicular helper cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell. go.json T-helper follicular cell differentiation http://purl.obolibrary.org/obo/GO_0061470 GO:1901016 biolink:BiologicalProcess regulation of potassium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. go.json regulation of potassium transporter activity http://purl.obolibrary.org/obo/GO_1901016 gocheck_do_not_annotate GO:0061471 biolink:BiologicalProcess karyomere assembly The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0061471 GO:1901013 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901013 GO:1901014 biolink:BiologicalProcess obsolete 3alpha(S)-strictosidine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 3alpha(S)-strictosidine. go.json 3alpha(S)-strictosidine breakdown|3alpha(S)-strictosidine catabolism|3alpha(S)-strictosidine degradation True http://purl.obolibrary.org/obo/GO_1901014 GO:0061472 biolink:BiologicalProcess karyomere membrane fusion Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus. go.json http://purl.obolibrary.org/obo/GO_0061472 GO:1901011 biolink:BiologicalProcess obsolete (S)-reticuline catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of (S)-reticuline. go.json (S)-reticuline breakdown|(S)-reticuline catabolism|(S)-reticuline degradation True http://purl.obolibrary.org/obo/GO_1901011 GO:0061473 biolink:MolecularActivity murein tripeptide carboxypeptidase activity Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate. go.json http://purl.obolibrary.org/obo/GO_0061473 GO:1901012 biolink:BiologicalProcess (S)-reticuline biosynthetic process The chemical reactions and pathways resulting in the formation of (S)-reticuline. go.json (S)-reticuline anabolism|(S)-reticuline biosynthesis|(S)-reticuline formation|(S)-reticuline synthesis http://purl.obolibrary.org/obo/GO_1901012 GO:0061474 biolink:CellularComponent phagolysosome membrane The lipid bilayer surrounding a phagolysosome. go.json http://purl.obolibrary.org/obo/GO_0061474 GO:1901020 biolink:BiologicalProcess negative regulation of calcium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity. go.json down regulation of calcium ion transmembrane transporter activity|down-regulation of calcium ion transmembrane transporter activity|downregulation of calcium ion transmembrane transporter activity|inhibition of calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901020 gocheck_do_not_annotate GO:0036420 biolink:CellularComponent extrinsic component of mycolate outer membrane The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to MOM|extrinsic to mycolate outer membrane|extrinsic to mycomembrane http://purl.obolibrary.org/obo/GO_0036420 GO:0061475 biolink:BiologicalProcess cytosolic valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0061475 GO:0036421 biolink:CellularComponent extrinsic component of external side of mycolate outer membrane The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. go.json extrinsic to external side of MOM|extrinsic to external side of mycolate outer membrane|extrinsic to external side of mycomembrane http://purl.obolibrary.org/obo/GO_0036421 GO:1901021 biolink:BiologicalProcess positive regulation of calcium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. go.json activation of calcium ion transmembrane transporter activity|up regulation of calcium ion transmembrane transporter activity|up-regulation of calcium ion transmembrane transporter activity|upregulation of calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901021 gocheck_do_not_annotate GO:0061476 biolink:BiologicalProcess response to anticoagulant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus. go.json http://purl.obolibrary.org/obo/GO_0061476 GO:0036422 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0036422 GO:0061477 biolink:BiologicalProcess response to aromatase inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus. go.json http://purl.obolibrary.org/obo/GO_0061477 GO:0061478 biolink:BiologicalProcess response to platelet aggregation inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus. go.json http://purl.obolibrary.org/obo/GO_0061478 GO:0036423 biolink:MolecularActivity hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate. EC:2.5.1.83|KEGG_REACTION:R09245|MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN|RHEA:27559 go.json hexaprenyl diphosphate synthase activity|hexaprenyl pyrophosphate synthetase activity http://purl.obolibrary.org/obo/GO_0036423 GO:0061479 biolink:BiologicalProcess response to reverse transcriptase inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus. go.json http://purl.obolibrary.org/obo/GO_0061479 GO:0036424 biolink:MolecularActivity L-phosphoserine phosphatase activity Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. EC:3.1.3.3|KEGG_REACTION:R00582|MetaCyc:PSERPHOSPHA-RXN|MetaCyc:RXN0-5114|RHEA:21208|Reactome:R-HSA-977324 go.json O-phosphoserine phosphohydrolase activity|phosphoserine phosphatase activity http://purl.obolibrary.org/obo/GO_0036424 GO:0036425 biolink:MolecularActivity obsolete D-phosphoserine phosphatase activity OBSOLETE. Catalysis of the reaction: O-phospho-D-serine + H2O = L-serine + phosphate, on a free amino acid. go.json True http://purl.obolibrary.org/obo/GO_0036425 GO:0036426 biolink:MolecularActivity ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP. KEGG_REACTION:R07257|MetaCyc:2.4.1.54-RXN go.json http://purl.obolibrary.org/obo/GO_0036426 GO:0036427 biolink:MolecularActivity all-trans-undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP. RHEA:28118 go.json http://purl.obolibrary.org/obo/GO_0036427 GO:1901028 biolink:BiologicalProcess regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. go.json regulation of MOMP|regulation of mitochondrial outer membrane permeabilization http://purl.obolibrary.org/obo/GO_1901028 GO:0036417 biolink:BiologicalProcess tRNA destabilization Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes. go.json http://purl.obolibrary.org/obo/GO_0036417 GO:1901029 biolink:BiologicalProcess negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. go.json down regulation of MOMP|down regulation of mitochondrial outer membrane permeabilization|down-regulation of MOMP|down-regulation of mitochondrial outer membrane permeabilization|downregulation of MOMP|downregulation of mitochondrial outer membrane permeabilization|inhibition of MOMP|inhibition of mitochondrial outer membrane permeabilization|negative regulation of MOMP|negative regulation of mitochondrial outer membrane permeabilization http://purl.obolibrary.org/obo/GO_1901029 GO:0036418 biolink:CellularComponent obsolete intrinsic component of mycolate outer membrane OBSOLETE. The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to MOM|intrinsic to mycolate outer membrane|intrinsic to mycomembrane True http://purl.obolibrary.org/obo/GO_0036418 GO:1901026 biolink:BiologicalProcess ripoptosome assembly involved in necroptotic process The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process. go.json ripoptosome assembly involved in necroptosis http://purl.obolibrary.org/obo/GO_1901026 GO:0036419 biolink:CellularComponent obsolete integral component of mycolate outer membrane OBSOLETE. The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to MOM|integral to mycolate outer membrane|integral to mycomembrane True http://purl.obolibrary.org/obo/GO_0036419 GO:1901027 biolink:BiologicalProcess dextrin catabolic process The chemical reactions and pathways resulting in the breakdown of dextrin. go.json dextrin breakdown|dextrin catabolism|dextrin degradation http://purl.obolibrary.org/obo/GO_1901027 GO:1901024 biolink:BiologicalProcess 4-hydroxyphenylacetate biosynthetic process The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate. go.json 4-hydroxyphenylacetate anabolism|4-hydroxyphenylacetate biosynthesis|4-hydroxyphenylacetate formation|4-hydroxyphenylacetate synthesis http://purl.obolibrary.org/obo/GO_1901024 GO:1901025 biolink:BiologicalProcess ripoptosome assembly involved in extrinsic apoptotic signaling pathway The aggregation, arrangement and bonding together of ripoptosome components leading to apoptosis via the extrinsic apoptotic signaling pathway. go.json http://purl.obolibrary.org/obo/GO_1901025 GO:1901022 biolink:BiologicalProcess 4-hydroxyphenylacetate metabolic process The chemical reactions and pathways involving 4-hydroxyphenylacetate. go.json 4-hydroxyphenylacetate metabolism http://purl.obolibrary.org/obo/GO_1901022 GO:1901023 biolink:BiologicalProcess 4-hydroxyphenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate. go.json 4-hydroxyphenylacetate breakdown|4-hydroxyphenylacetate catabolism|4-hydroxyphenylacetate degradation http://purl.obolibrary.org/obo/GO_1901023 GO:1901031 biolink:BiologicalProcess regulation of response to reactive oxygen species Any process that modulates the frequency, rate or extent of response to reactive oxygen species. go.json regulation of response to AOS|regulation of response to ROI|regulation of response to ROS|regulation of response to active oxygen species|regulation of response to reactive oxidative species|regulation of response to reactive oxygen intermediate http://purl.obolibrary.org/obo/GO_1901031 GO:1901032 biolink:BiologicalProcess negative regulation of response to reactive oxygen species Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. go.json down regulation of response to AOS|down regulation of response to ROI|down regulation of response to ROS|down regulation of response to active oxygen species|down regulation of response to reactive oxidative species|down regulation of response to reactive oxygen intermediate|down regulation of response to reactive oxygen species|down-regulation of response to AOS|down-regulation of response to ROI|down-regulation of response to ROS|down-regulation of response to active oxygen species|down-regulation of response to reactive oxidative species|down-regulation of response to reactive oxygen intermediate|down-regulation of response to reactive oxygen species|downregulation of response to AOS|downregulation of response to ROI|downregulation of response to ROS|downregulation of response to active oxygen species|downregulation of response to reactive oxidative species|downregulation of response to reactive oxygen intermediate|downregulation of response to reactive oxygen species|inhibition of response to AOS|inhibition of response to ROI|inhibition of response to ROS|inhibition of response to active oxygen species|inhibition of response to reactive oxidative species|inhibition of response to reactive oxygen intermediate|inhibition of response to reactive oxygen species|negative regulation of response to AOS|negative regulation of response to ROI|negative regulation of response to ROS|negative regulation of response to active oxygen species|negative regulation of response to reactive oxidative species|negative regulation of response to reactive oxygen intermediate http://purl.obolibrary.org/obo/GO_1901032 GO:0036410 biolink:CellularComponent Mst2 histone acetyltransferase complex A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6. go.json Mst2 H3K14 acetyltransferase complex|Mst2 complex|Mst2 histone H3K14 acetyltransferase complex http://purl.obolibrary.org/obo/GO_0036410 GO:0036411 biolink:CellularComponent H-NS-Cnu complex A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes. go.json http://purl.obolibrary.org/obo/GO_0036411 GO:1901030 biolink:BiologicalProcess positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. go.json activation of MOMP|activation of mitochondrial outer membrane permeabilization|positive regulation of MOMP|positive regulation of mitochondrial outer membrane permeabilization|up regulation of MOMP|up regulation of mitochondrial outer membrane permeabilization|up-regulation of MOMP|up-regulation of mitochondrial outer membrane permeabilization|upregulation of MOMP|upregulation of mitochondrial outer membrane permeabilization http://purl.obolibrary.org/obo/GO_1901030 GO:0036412 biolink:MolecularActivity acetyl-CoA:oxalate CoA-transferase Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA. RHEA:37883 go.json http://purl.obolibrary.org/obo/GO_0036412 GO:0036413 biolink:BiologicalProcess obsolete histone H3-R26 citrullination OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3. go.json histone H3 arginine 26 citrullination True http://purl.obolibrary.org/obo/GO_0036413 GO:0036414 biolink:BiologicalProcess obsolete histone citrullination OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein. go.json histone deimination True http://purl.obolibrary.org/obo/GO_0036414 GO:0036415 biolink:BiologicalProcess regulation of tRNA stability Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs. go.json http://purl.obolibrary.org/obo/GO_0036415 GO:0036416 biolink:BiologicalProcess tRNA stabilization Prevention of degradation of tRNA molecules. go.json http://purl.obolibrary.org/obo/GO_0036416 GO:0036406 biolink:CellularComponent obsolete anchored component of periplasmic side of cell outer membrane OBSOLETE. The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only. go.json anchored to internal side of cell outer membrane|anchored to periplasmic side of cell outer membrane True http://purl.obolibrary.org/obo/GO_0036406 GO:1901039 biolink:BiologicalProcess regulation of peptide antigen transport Any process that modulates the frequency, rate or extent of peptide antigen transport. go.json http://purl.obolibrary.org/obo/GO_1901039 GO:0061490 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061490 GO:0036407 biolink:CellularComponent mycolate outer membrane A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria). go.json MOM|mycobacterial outer membrane|mycomembrane http://purl.obolibrary.org/obo/GO_0036407 GO:1901037 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle OBSOLETE. Any process that regulates transcription such that the target genes are transcribed during the M/G1 transition of the mitotic cell cycle. go.json global transcription regulation from Pol II promoter during M/G1 transition of mitotic cell cycle|regulation of gene-specific transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle|regulation of global transcription from Pol II promoter during M/G1 transition of mitotic cell cycle|regulation of transcription during M/G1 transition of mitotic cell cycle|regulation of transcription from Pol II promoter during M/G1 transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter involved in M/G1 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_1901037 GO:0036408 biolink:MolecularActivity histone H3K14 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14). go.json histone H3-K14 acetyltransferase activity|histone acetylase activity (H3-K14 specific)|histone acetyltransferase activity (H3-K14 specific)|histone lysine N-acetyltransferase activity (H3-K14 specific) http://purl.obolibrary.org/obo/GO_0036408 GO:0061491 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061491 GO:0036409 biolink:CellularComponent histone H3-K14 acetyltransferase complex A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3. go.json H3-K14 histone acetyltransferase complex|histone H3 Lys 14 (H3K14) acetyltransferase complex|histone H3K14 acetyltransferase complex|histone acetyltransferase complex (H3-K14 specific) http://purl.obolibrary.org/obo/GO_0036409 GO:0061492 biolink:BiologicalProcess asymmetric protein localization to old or new spindle pole body Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically. go.json http://purl.obolibrary.org/obo/GO_0061492 GO:1901038 biolink:BiologicalProcess cyanidin 3-O-glucoside metabolic process The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside. go.json cyanidin 3-O-beta-D-glucoside metabolic process|cyanidin 3-O-beta-D-glucoside metabolism http://purl.obolibrary.org/obo/GO_1901038 GO:0061493 biolink:CellularComponent central plaque of mitotic spindle pole body One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0061493 GO:1901035 biolink:BiologicalProcess negative regulation of L-glutamine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine import into a cell. go.json down regulation of L-glutamine import|down regulation of L-glutamine uptake|down-regulation of L-glutamine import|down-regulation of L-glutamine uptake|downregulation of L-glutamine import|downregulation of L-glutamine uptake|inhibition of L-glutamine import|inhibition of L-glutamine uptake|negative regulation of L-glutamine import|negative regulation of L-glutamine uptake http://purl.obolibrary.org/obo/GO_1901035 GO:1901036 biolink:BiologicalProcess positive regulation of L-glutamine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-glutamine import into cell. go.json activation of L-glutamine import|activation of L-glutamine uptake|positive regulation of L-glutamine import|positive regulation of L-glutamine uptake|up regulation of L-glutamine import|up regulation of L-glutamine uptake|up-regulation of L-glutamine import|up-regulation of L-glutamine uptake|upregulation of L-glutamine import|upregulation of L-glutamine uptake http://purl.obolibrary.org/obo/GO_1901036 GO:0061494 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061494 GO:1901033 biolink:BiologicalProcess positive regulation of response to reactive oxygen species Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species. go.json activation of response to AOS|activation of response to ROI|activation of response to ROS|activation of response to active oxygen species|activation of response to reactive oxidative species|activation of response to reactive oxygen intermediate|activation of response to reactive oxygen species|positive regulation of response to AOS|positive regulation of response to ROI|positive regulation of response to ROS|positive regulation of response to active oxygen species|positive regulation of response to reactive oxidative species|positive regulation of response to reactive oxygen intermediate|up regulation of response to AOS|up regulation of response to ROI|up regulation of response to ROS|up regulation of response to active oxygen species|up regulation of response to reactive oxidative species|up regulation of response to reactive oxygen intermediate|up regulation of response to reactive oxygen species|up-regulation of response to AOS|up-regulation of response to ROI|up-regulation of response to ROS|up-regulation of response to active oxygen species|up-regulation of response to reactive oxidative species|up-regulation of response to reactive oxygen intermediate|up-regulation of response to reactive oxygen species|upregulation of response to AOS|upregulation of response to ROI|upregulation of response to ROS|upregulation of response to active oxygen species|upregulation of response to reactive oxidative species|upregulation of response to reactive oxygen intermediate|upregulation of response to reactive oxygen species http://purl.obolibrary.org/obo/GO_1901033 GO:0061495 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061495 GO:0061496 biolink:CellularComponent half bridge of mitotic spindle pole body Structure adjacent to the plaques of the mitotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0061496 GO:1901034 biolink:BiologicalProcess regulation of L-glutamine import across plasma membrane Any process that modulates the frequency, rate or extent of L-glutamine import into cell. go.json regulation of L-glutamine import|regulation of L-glutamine uptake http://purl.obolibrary.org/obo/GO_1901034 GO:0061497 biolink:CellularComponent inner plaque of mitotic spindle pole body One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus. go.json http://purl.obolibrary.org/obo/GO_0061497 GO:1901042 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901042 GO:1901043 biolink:BiologicalProcess obsolete protein polyubiquitination involved in cellular response to misfolded protein OBSOLETE. Any protein polyubiquitination that is involved in cellular response to misfolded protein. go.json polyubiquitin of cellular response to misfolded protein|protein polyubiquitination involved in cellular response to misfolded protein|protein polyubiquitination of cellular response to misfolded protein|protein polyubiquitinylation of cellular response to misfolded protein|protein polyubiquitylation of cellular response to misfolded protein True http://purl.obolibrary.org/obo/GO_1901043 GO:0061498 biolink:CellularComponent intermediate layer of mitotic spindle pole body Structure between the central and outer plaques of the mitotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0061498 GO:1901040 biolink:BiologicalProcess negative regulation of peptide antigen transport Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport. go.json down regulation of peptide antigen transport|down-regulation of peptide antigen transport|downregulation of peptide antigen transport|inhibition of peptide antigen transport http://purl.obolibrary.org/obo/GO_1901040 GO:0036400 biolink:MolecularActivity short neuropeptide F receptor activity Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide. go.json sNPF receptor activity http://purl.obolibrary.org/obo/GO_0036400 GO:0061499 biolink:CellularComponent outer plaque of mitotic spindle pole body One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0061499 GO:0036401 biolink:MolecularActivity pyrokinin receptor activity Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation. go.json PK receptor activity http://purl.obolibrary.org/obo/GO_0036401 GO:1901041 biolink:BiologicalProcess positive regulation of peptide antigen transport Any process that activates or increases the frequency, rate or extent of peptide antigen transport. go.json activation of peptide antigen transport|up regulation of peptide antigen transport|up-regulation of peptide antigen transport|upregulation of peptide antigen transport http://purl.obolibrary.org/obo/GO_1901041 GO:0036402 biolink:MolecularActivity proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. EC:5.6.1.5 go.json ATPase involved in positive regulation of proteasomal protein catabolic process|proteasomal ATPase activity|proteasome channel gating activity|proteasome channel opening activity|proteasome-activating ATPase activity http://purl.obolibrary.org/obo/GO_0036402 GO:0036403 biolink:MolecularActivity arachidonate 8(S)-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. KEGG_REACTION:R07053|RHEA:38675 go.json 8(S)-lipoxygenase activity|8-lipoxygenase (S-type) http://purl.obolibrary.org/obo/GO_0036403 GO:0036404 biolink:BiologicalProcess obsolete conversion of ds siRNA to ss siRNA OBSOLETE. The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA). go.json conversion of double-stranded small interfering RNA to single-stranded small interfering RNA True http://purl.obolibrary.org/obo/GO_0036404 GO:0036405 biolink:CellularComponent obsolete anchored component of cell outer membrane OBSOLETE. The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json anchored to cell outer membrane True http://purl.obolibrary.org/obo/GO_0036405 GO:0120219 biolink:CellularComponent subapical part of cell The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina. go.json subapical region of cell http://purl.obolibrary.org/obo/GO_0120219 GO:0120215 biolink:BiologicalProcess positive regulation of histidine biosynthetic process Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process. go.json activation of histidine anabolism|activation of histidine biosynthesis|activation of histidine biosynthetic process|activation of histidine formation|activation of histidine synthesis|positive regulation of histidine anabolism|positive regulation of histidine biosynthesis|positive regulation of histidine formation|positive regulation of histidine synthesis|up regulation of histidine anabolism|up regulation of histidine biosynthesis|up regulation of histidine biosynthetic process|up regulation of histidine formation|up regulation of histidine synthesis|up-regulation of histidine anabolism|up-regulation of histidine biosynthesis|up-regulation of histidine biosynthetic process|up-regulation of histidine formation|up-regulation of histidine synthesis|upregulation of histidine anabolism|upregulation of histidine biosynthesis|upregulation of histidine biosynthetic process|upregulation of histidine formation|upregulation of histidine synthesis http://purl.obolibrary.org/obo/GO_0120215 GO:0120216 biolink:CellularComponent matrilin complex A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer. go.json matrilin family complex|matrilin-1 complex|matrilin-2 complex|matrilin-3 complex|matrilin-4 complex http://purl.obolibrary.org/obo/GO_0120216 GO:0120217 biolink:CellularComponent DNA gyrase complex A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB). go.json topoisomerase II complex http://purl.obolibrary.org/obo/GO_0120217 GO:0120218 biolink:BiologicalProcess host interaction involved in quorum sensing A quorum sensing process that is modulated by some interaction with a host cell or organism. go.json http://purl.obolibrary.org/obo/GO_0120218 GO:2000063 biolink:BiologicalProcess positive regulation of ureter smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000063 GO:0120211 biolink:BiologicalProcess proacrosomal vesicle fusion Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome. go.json http://purl.obolibrary.org/obo/GO_0120211 GO:2000064 biolink:BiologicalProcess regulation of cortisol biosynthetic process Any process that modulates the frequency, rate or extent of cortisol biosynthetic process. go.json regulation of cortisol anabolism|regulation of cortisol biosynthesis|regulation of cortisol formation|regulation of cortisol synthesis http://purl.obolibrary.org/obo/GO_2000064 GO:0120212 biolink:CellularComponent sperm head-tail coupling apparatus A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head. go.json HTCA|head-tail coupling apparatus|implantation fossa http://purl.obolibrary.org/obo/GO_0120212 GO:2000065 biolink:BiologicalProcess negative regulation of cortisol biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process. go.json negative regulation of cortisol anabolism|negative regulation of cortisol biosynthesis|negative regulation of cortisol formation|negative regulation of cortisol synthesis http://purl.obolibrary.org/obo/GO_2000065 GO:0120213 biolink:BiologicalProcess regulation of histidine biosynthetic process Any process that modulates the frequency, rate or extent of histidine biosynthetic process. go.json regulation of histidine anabolism|regulation of histidine biosynthesis|regulation of histidine formation|regulation of histidine synthesis http://purl.obolibrary.org/obo/GO_0120213 GO:2000066 biolink:BiologicalProcess positive regulation of cortisol biosynthetic process Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process. go.json positive regulation of cortisol anabolism|positive regulation of cortisol biosynthesis|positive regulation of cortisol formation|positive regulation of cortisol synthesis http://purl.obolibrary.org/obo/GO_2000066 GO:0120214 biolink:BiologicalProcess negative regulation of histidine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process. go.json down regulation of histidine anabolism|down regulation of histidine biosynthesis|down regulation of histidine biosynthetic process|down regulation of histidine formation|down regulation of histidine synthesis|down-regulation of histidine anabolism|down-regulation of histidine biosynthesis|down-regulation of histidine biosynthetic process|down-regulation of histidine formation|down-regulation of histidine synthesis|downregulation of histidine anabolism|downregulation of histidine biosynthesis|downregulation of histidine biosynthetic process|downregulation of histidine formation|downregulation of histidine synthesis|inhibition of histidine anabolism|inhibition of histidine biosynthesis|inhibition of histidine biosynthetic process|inhibition of histidine formation|inhibition of histidine synthesis|negative regulation of histidine anabolism|negative regulation of histidine biosynthesis|negative regulation of histidine formation|negative regulation of histidine synthesis http://purl.obolibrary.org/obo/GO_0120214 GO:2000067 biolink:BiologicalProcess regulation of root morphogenesis Any process that modulates the frequency, rate or extent of root morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000067 GO:2000068 biolink:BiologicalProcess regulation of defense response to insect Any process that modulates the frequency, rate or extent of defense response to insect. go.json regulation of physiological defense response to insect http://purl.obolibrary.org/obo/GO_2000068 GO:2000069 biolink:BiologicalProcess regulation of post-embryonic root development Any process that modulates the frequency, rate or extent of post-embryonic root development. go.json http://purl.obolibrary.org/obo/GO_2000069 GO:0120210 biolink:CellularComponent rod telodendria Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina. go.json http://purl.obolibrary.org/obo/GO_0120210 GO:2000060 biolink:BiologicalProcess positive regulation of ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process. go.json positive regulation of protein degradation tagging activity|positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown|positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism|positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism|positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism http://purl.obolibrary.org/obo/GO_2000060 GO:2000061 biolink:BiologicalProcess regulation of ureter smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000061 GO:2000062 biolink:BiologicalProcess negative regulation of ureter smooth muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000062 GO:0120226 biolink:MolecularActivity succinyl-CoA binding Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component. go.json succinyl-coenzyme A binding http://purl.obolibrary.org/obo/GO_0120226 GO:0120227 biolink:MolecularActivity acyl-CoA binding Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid. go.json acyl binding|acyl-coenzyme A binding http://purl.obolibrary.org/obo/GO_0120227 GO:0120228 biolink:CellularComponent outer dynein arm docking complex A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules. go.json ODA docking complex|ODA-DC http://purl.obolibrary.org/obo/GO_0120228 GO:0120229 biolink:BiologicalProcess protein localization to motile cilium A process in which a protein is transported to, or maintained in, a location within a motile cilium. go.json protein localization to nonmotile primary cilium http://purl.obolibrary.org/obo/GO_0120229 GO:0120222 biolink:BiologicalProcess regulation of blastocyst development Any process that modulates the frequency, rate or extent of blastocyst development. go.json http://purl.obolibrary.org/obo/GO_0120222 GO:2000074 biolink:BiologicalProcess regulation of type B pancreatic cell development Any process that modulates the frequency, rate or extent of pancreatic B cell development. go.json regulation of pancreatic B cell development|regulation of pancreatic beta cell development http://purl.obolibrary.org/obo/GO_2000074 GO:2000075 biolink:BiologicalProcess negative regulation of cytokinesis, site selection Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis. go.json negative regulation of site selection involved in cell cycle cytokinesis http://purl.obolibrary.org/obo/GO_2000075 GO:0120223 biolink:BiologicalProcess larynx morphogenesis The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. go.json laryngeal morphogenesis http://purl.obolibrary.org/obo/GO_0120223 GO:0120224 biolink:BiologicalProcess larynx development The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. go.json http://purl.obolibrary.org/obo/GO_0120224 GO:2000076 biolink:BiologicalProcess positive regulation of cytokinesis, site selection Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis. go.json positive regulation of site selection involved in cell cycle cytokinesis http://purl.obolibrary.org/obo/GO_2000076 GO:2000077 biolink:BiologicalProcess negative regulation of type B pancreatic cell development Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. go.json negative regulation of pancreatic B cell development|negative regulation of pancreatic beta cell development http://purl.obolibrary.org/obo/GO_2000077 GO:0120225 biolink:MolecularActivity coenzyme A binding Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. go.json CoA binding http://purl.obolibrary.org/obo/GO_0120225 GO:2000078 biolink:BiologicalProcess positive regulation of type B pancreatic cell development Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. go.json positive regulation of pancreatic B cell development|positive regulation of pancreatic beta cell development http://purl.obolibrary.org/obo/GO_2000078 GO:2000079 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. go.json regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation|regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation|regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation|regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation|regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation http://purl.obolibrary.org/obo/GO_2000079 GO:0120220 biolink:CellularComponent basal body patch The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster. go.json centriolar patch http://purl.obolibrary.org/obo/GO_0120220 GO:0120221 biolink:BiologicalProcess maintenance of ciliary planar beating movement pattern Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement. go.json http://purl.obolibrary.org/obo/GO_0120221 GO:2000070 biolink:BiologicalProcess regulation of response to water deprivation Any process that modulates the frequency, rate or extent of response to water deprivation. go.json regulation of drought tolerance|regulation of response to dehydration|regulation of response to drought|regulation of response to thirst http://purl.obolibrary.org/obo/GO_2000070 GO:2000071 biolink:BiologicalProcess regulation of defense response by callose deposition Any process that modulates the frequency, rate or extent of defense response by callose deposition. go.json regulation of callose deposition during defense response|regulation of callose localization during defense response http://purl.obolibrary.org/obo/GO_2000071 GO:2000072 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000072 GO:2000073 biolink:BiologicalProcess regulation of cytokinesis, site selection Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis. go.json regulation of site selection involved in cell cycle cytokinesis http://purl.obolibrary.org/obo/GO_2000073 GO:0120237 biolink:BiologicalProcess terminal acetylenic compound biosynthetic process The chemical reactions and pathways resulting in the formation of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom. go.json terminal alkyne substituted compound anabolic process|terminal alkyne substituted compound anabolism|terminal alkyne substituted compound biosynthesis|terminal alkyne substituted compound biosynthetic process|terminal alkyne substituted compound synthesis http://purl.obolibrary.org/obo/GO_0120237 GO:0120238 biolink:CellularComponent sperm glycocalyx The carbohydrate rich layer at the outermost periphery of a sperm cell. go.json http://purl.obolibrary.org/obo/GO_0120238 GO:0120239 biolink:CellularComponent vascular endothelial glycocalyx The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated. go.json endothelial glycocalyx http://purl.obolibrary.org/obo/GO_0120239 GO:2000085 biolink:BiologicalProcess negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis. go.json negative regulation of mesonephric mesenchyme to epithelial transition http://purl.obolibrary.org/obo/GO_2000085 GO:0120233 biolink:MolecularActivity prenyl-FMNH2 binding Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1. go.json prenylated FMNH2 binding http://purl.obolibrary.org/obo/GO_0120233 GO:2000086 biolink:BiologicalProcess positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis. go.json positive regulation of mesonephric mesenchyme to epithelial transition http://purl.obolibrary.org/obo/GO_2000086 GO:0120234 biolink:CellularComponent stereocilium coat A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle. go.json auditory hair cell glycocalyx|stereocilium glycocalyx http://purl.obolibrary.org/obo/GO_0120234 GO:0120235 biolink:BiologicalProcess regulation of post-translational protein targeting to membrane, translocation Any process that modulates the frequency, rate or extent of posttranslational protein translocation through the ER membrane. go.json regulation of N-terminal signal peptide-independent translocation into the ER|regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation|regulation of posttranslational endoplasmic reticulum membrane protein translocation|regulation of posttranslational protein targeting to membrane, translocation http://purl.obolibrary.org/obo/GO_0120235 GO:2000087 biolink:BiologicalProcess regulation of mesonephric glomerulus development Any process that modulates the frequency, rate or extent of mesonephric glomerulus development. go.json http://purl.obolibrary.org/obo/GO_2000087 GO:2000088 biolink:BiologicalProcess negative regulation of mesonephric glomerulus development Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development. go.json http://purl.obolibrary.org/obo/GO_2000088 GO:0120236 biolink:BiologicalProcess negative regulation of post-translational protein targeting to membrane, translocation Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane. go.json negative regulation of N-terminal signal peptide-independent translocation into the ER|negative regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation|negative regulation of posttranslational endoplasmic reticulum membrane protein translocation|negative regulation of posttranslational protein targeting to membrane, translocation http://purl.obolibrary.org/obo/GO_0120236 GO:2000089 biolink:BiologicalProcess positive regulation of mesonephric glomerulus development Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development. go.json http://purl.obolibrary.org/obo/GO_2000089 GO:0120230 biolink:MolecularActivity recombinase activator activity Binds to and increases the activity of a recombinase. go.json http://purl.obolibrary.org/obo/GO_0120230 GO:0120231 biolink:CellularComponent DNA recombinase auxiliary factor complex A protein complex that binds to a recombinase and incrseases its activity. go.json DNA recombinase accessory factor complex|DNA recombinase activator complex http://purl.obolibrary.org/obo/GO_0120231 GO:0120232 biolink:BiologicalProcess prenyl-FMNH2 biosynthetic process The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1. go.json prenyl-FMNH2 anabolism|prenyl-FMNH2 biosynthesis|prenyl-FMNH2 formation|prenyl-FMNH2 synthesis|prenylated FMNH2 anabolism|prenylated FMNH2 biosynthesis|prenylated FMNH2 biosynthetic process|prenylated FMNH2 formation|prenylated FMNH2 synthesis http://purl.obolibrary.org/obo/GO_0120232 GO:2000080 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. go.json negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation|negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation|negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation http://purl.obolibrary.org/obo/GO_2000080 GO:2000081 biolink:BiologicalProcess positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. go.json positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation|positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation|positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation|positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation|positive regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation http://purl.obolibrary.org/obo/GO_2000081 GO:2000082 biolink:BiologicalProcess regulation of L-ascorbic acid biosynthetic process Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process. go.json regulation of L-ascorbic acid anabolism|regulation of L-ascorbic acid biosynthesis|regulation of L-ascorbic acid formation|regulation of L-ascorbic acid synthesis|regulation of ascorbate biosynthesis|regulation of ascorbate biosynthetic process|regulation of vitamin C biosynthesis|regulation of vitamin C biosynthetic process http://purl.obolibrary.org/obo/GO_2000082 GO:2000083 biolink:BiologicalProcess negative regulation of L-ascorbic acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process. go.json negative regulation of L-ascorbic acid anabolism|negative regulation of L-ascorbic acid biosynthesis|negative regulation of L-ascorbic acid formation|negative regulation of L-ascorbic acid synthesis|negative regulation of ascorbate biosynthesis|negative regulation of ascorbate biosynthetic process|negative regulation of vitamin C biosynthesis|negative regulation of vitamin C biosynthetic process http://purl.obolibrary.org/obo/GO_2000083 GO:2000084 biolink:BiologicalProcess regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis. go.json regulation of mesonephric mesenchyme to epithelial transition http://purl.obolibrary.org/obo/GO_2000084 GO:0120248 biolink:BiologicalProcess acetylenic compound catabolic process The chemical reactions and pathways resulting in the breakdown of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C). go.json alkyne substituted compound breakdown|alkyne substituted compound catabolic process|alkyne substituted compound catabolism|alkyne substituted compound degradation http://purl.obolibrary.org/obo/GO_0120248 GO:0120249 biolink:CellularComponent lateral wall of outer hair cell The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae. go.json OHC lateral wall|lateral wall of OHC|outer hair cell lateral wall http://purl.obolibrary.org/obo/GO_0120249 GO:2000096 biolink:BiologicalProcess positive regulation of Wnt signaling pathway, planar cell polarity pathway Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. go.json positive regulation of PCP pathway|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway|positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway|positive regulation of Wnt-JNK signaling pathway|positive regulation of Wnt-PCP signaling pathway|positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway|positive regulation of non-canonical Wnt signaling pathway http://purl.obolibrary.org/obo/GO_2000096 GO:0120244 biolink:BiologicalProcess terminal acetylenic compound metabolic process The chemical reactions and pathways involving a terminal acetylenic compound, involving a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom. go.json terminal alkyne substituted compound metabolic process|terminal alkyne substituted compound metabolism http://purl.obolibrary.org/obo/GO_0120244 GO:2000097 biolink:BiologicalProcess regulation of smooth muscle cell-matrix adhesion Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_2000097 GO:0120245 biolink:BiologicalProcess terminal acetylenic compound catabolic process The chemical reactions and pathways resulting in the breakdown of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom. go.json terminal alkyne substituted compound breakdown|terminal alkyne substituted compound catabolic process|terminal alkyne substituted compound catabolism|terminal alkyne substituted compound degradation http://purl.obolibrary.org/obo/GO_0120245 GO:0120246 biolink:BiologicalProcess acetylenic compound metabolic process The chemical reactions and pathways involving an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C). go.json alkyne substituted compound metabolic process|alkyne substituted compound metabolism http://purl.obolibrary.org/obo/GO_0120246 GO:2000098 biolink:BiologicalProcess negative regulation of smooth muscle cell-matrix adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_2000098 GO:0120247 biolink:BiologicalProcess acetylenic compound biosynthetic process The chemical reactions and pathways resulting in the formation of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C). go.json alkyne substituted compound anabolic process|alkyne substituted compound anabolism|alkyne substituted compound biosynthesis|alkyne substituted compound biosynthetic process|alkyne substituted compound synthesis http://purl.obolibrary.org/obo/GO_0120247 GO:2000099 biolink:BiologicalProcess regulation of establishment or maintenance of bipolar cell polarity Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity. go.json http://purl.obolibrary.org/obo/GO_2000099 GO:0120240 biolink:CellularComponent platelet glycocalyx The carbohydrate rich layer at the outermost periphery of a platelet. go.json http://purl.obolibrary.org/obo/GO_0120240 GO:0120241 biolink:MolecularActivity 2-iminobutanoate/2-iminopropanoate deaminase Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. EC:3.5.99.10 go.json 2-iminobutanoate deaminase|2-iminopropanoate deaminase|enamine/imine deaminase|imine intermediate deaminase activity http://purl.obolibrary.org/obo/GO_0120241 GO:0120242 biolink:MolecularActivity 2-iminobutanoate deaminase activity Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+). KEGG_REACTION:R11098|MetaCyc:RXN-15123|RHEA:39975 go.json 2-iminobutanoate/2-iminopropanoate deaminase http://purl.obolibrary.org/obo/GO_0120242 GO:0120243 biolink:MolecularActivity 2-iminopropanoate deaminase activity Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate. KEGG_REACTION:R11099|MetaCyc:RXN-15127|RHEA:40671 go.json 2-iminobutanoate/2-iminopropanoate deaminase http://purl.obolibrary.org/obo/GO_0120243 GO:2000090 biolink:BiologicalProcess regulation of mesonephric glomerular mesangial cell proliferation Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000090 GO:2000091 biolink:BiologicalProcess negative regulation of mesonephric glomerular mesangial cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000091 GO:2000092 biolink:BiologicalProcess positive regulation of mesonephric glomerular mesangial cell proliferation Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000092 GO:2000093 biolink:BiologicalProcess regulation of mesonephric nephron tubule epithelial cell differentiation Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000093 GO:2000094 biolink:BiologicalProcess negative regulation of mesonephric nephron tubule epithelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000094 GO:2000095 biolink:BiologicalProcess regulation of Wnt signaling pathway, planar cell polarity pathway Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. go.json regulation of PCP pathway|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|regulation of Wnt receptor signalling pathway, planar cell polarity pathway|regulation of Wnt-JNK signaling pathway|regulation of Wnt-PCP signaling pathway|regulation of Wnt-activated signaling pathway, planar cell polarity pathway|regulation of non-canonical Wnt signaling pathway http://purl.obolibrary.org/obo/GO_2000095 GO:2000027 biolink:BiologicalProcess regulation of animal organ morphogenesis Any process that modulates the frequency, rate or extent of animal organ morphogenesis. go.json regulation of histogenesis and organogenesis http://purl.obolibrary.org/obo/GO_2000027 GO:2000028 biolink:BiologicalProcess regulation of photoperiodism, flowering Any process that modulates the frequency, rate or extent of photoperiodism, flowering. go.json regulation of photoperiodic control of flowering time|regulation of photoperiodic control of inflorescence development|regulation of response to day length, flowering|regulation of response to night length, flowering|regulation of response to photoperiod, flowering http://purl.obolibrary.org/obo/GO_2000028 GO:2000029 biolink:BiologicalProcess regulation of proanthocyanidin biosynthetic process Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process. go.json regulation of proanthocyanidin anabolism|regulation of proanthocyanidin biosynthesis|regulation of proanthocyanidin formation|regulation of proanthocyanidin synthesis http://purl.obolibrary.org/obo/GO_2000029 GO:2000020 biolink:BiologicalProcess positive regulation of male gonad development Any process that activates or increases the frequency, rate or extent of male gonad development. go.json positive regulation of testicular development|positive regulation of testis development http://purl.obolibrary.org/obo/GO_2000020 GO:2000021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000021 GO:0061400 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to calcium ion OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061400 GO:0061401 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json True http://purl.obolibrary.org/obo/GO_0061401 GO:2000022 biolink:BiologicalProcess regulation of jasmonic acid mediated signaling pathway Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway. go.json regulation of jasmonic acid mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000022 GO:0061402 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7. go.json positive regulation of transcription from RNA polymerase II promoter in response to acidity http://purl.obolibrary.org/obo/GO_0061402 GO:2000023 biolink:BiologicalProcess regulation of lateral root development Any process that modulates the frequency, rate or extent of lateral root development. go.json http://purl.obolibrary.org/obo/GO_2000023 GO:0061403 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. go.json True http://purl.obolibrary.org/obo/GO_0061403 GO:2000024 biolink:BiologicalProcess regulation of leaf development Any process that modulates the frequency, rate or extent of leaf development. go.json http://purl.obolibrary.org/obo/GO_2000024 GO:0061404 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to increased salt OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json True http://purl.obolibrary.org/obo/GO_0061404 GO:2000025 biolink:BiologicalProcess regulation of leaf formation Any process that modulates the frequency, rate or extent of leaf formation. go.json http://purl.obolibrary.org/obo/GO_2000025 GO:2000026 biolink:BiologicalProcess regulation of multicellular organismal development Any process that modulates the frequency, rate or extent of multicellular organismal development. go.json http://purl.obolibrary.org/obo/GO_2000026 GO:0061405 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. go.json True http://purl.obolibrary.org/obo/GO_0061405 GO:0061406 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose. go.json http://purl.obolibrary.org/obo/GO_0061406 GO:0061407 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0061407 GO:0061408 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to heat stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. go.json http://purl.obolibrary.org/obo/GO_0061408 GO:0061409 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to freezing OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius. go.json True http://purl.obolibrary.org/obo/GO_0061409 GO:2000038 biolink:BiologicalProcess regulation of stomatal complex development Any process that modulates the frequency, rate or extent of stomatal complex development. go.json http://purl.obolibrary.org/obo/GO_2000038 GO:2000039 biolink:BiologicalProcess regulation of trichome morphogenesis Any process that modulates the frequency, rate or extent of trichome morphogenesis. go.json regulation of trichome cell morphogenesis during differentiation http://purl.obolibrary.org/obo/GO_2000039 GO:2000030 biolink:BiologicalProcess regulation of response to red or far red light Any process that modulates the frequency, rate or extent of response to red or far red light. go.json http://purl.obolibrary.org/obo/GO_2000030 GO:2000031 biolink:BiologicalProcess regulation of salicylic acid mediated signaling pathway Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway. go.json regulation of salicylic acid mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000031 GO:2000032 biolink:BiologicalProcess regulation of secondary shoot formation Any process that modulates the frequency, rate or extent of secondary shoot formation. go.json regulation of auxiliary shoot formation|regulation of axillary shoot formation|regulation of axillary shoot system formation|regulation of shoot branching http://purl.obolibrary.org/obo/GO_2000032 GO:2000033 biolink:BiologicalProcess regulation of seed dormancy process Any process that modulates the frequency, rate or extent of seed dormancy process. go.json regulation of seed dormancy http://purl.obolibrary.org/obo/GO_2000033 GO:2000034 biolink:BiologicalProcess regulation of seed maturation Any process that modulates the frequency, rate or extent of seed maturation. go.json http://purl.obolibrary.org/obo/GO_2000034 GO:2000035 biolink:BiologicalProcess regulation of stem cell division Any process that modulates the frequency, rate or extent of stem cell division. go.json regulation of stem cell renewal http://purl.obolibrary.org/obo/GO_2000035 GO:2000036 biolink:BiologicalProcess regulation of stem cell population maintenance Any process that modulates the frequency, rate or extent of stem cell population maintenance. go.json regulation of maintenance of pluripotency http://purl.obolibrary.org/obo/GO_2000036 GO:2000037 biolink:BiologicalProcess regulation of stomatal complex patterning Any process that modulates the frequency, rate or extent of stomatal complex patterning. go.json http://purl.obolibrary.org/obo/GO_2000037 GO:2000049 biolink:BiologicalProcess positive regulation of cell-cell adhesion mediated by cadherin Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. go.json http://purl.obolibrary.org/obo/GO_2000049 GO:0061420 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to biotin starvation OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin. go.json True http://purl.obolibrary.org/obo/GO_0061420 GO:2000041 biolink:BiologicalProcess negative regulation of planar cell polarity pathway involved in axis elongation Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation. go.json http://purl.obolibrary.org/obo/GO_2000041 GO:0036497 biolink:BiologicalProcess eIF2alpha dephosphorylation in response to endoplasmic reticulum stress The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. go.json eIF2alpha dephosphorylation in response to ER stress|regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_0036497 gocheck_do_not_annotate GO:0036498 biolink:BiologicalProcess IRE1-mediated unfolded protein response The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. go.json ERN1-mediated unfolded protein response|IRE1 branch of UPR|IRE1 signal transduction pathway|IRE1 signaling in response to endoplasmic reticulum stress|IRE1alpha unfolded protein response|IRE1p unfolded protein response|UPR signaling by IRE1 stress sensor|endoplasmic reticulum unfolded protein response; IRE1 signaling|inositol-requiring enzyme 1-mediated unfolded protein response|inositol-requiring transmembrane kinase/endonuclease signal transduction http://purl.obolibrary.org/obo/GO_0036498 GO:0061421 biolink:BiologicalProcess obsolete positive regulation of transcription by oleic acid OBSOLETE. Any process involving oleic acid that activates or increases the rate of transcription. go.json True http://purl.obolibrary.org/obo/GO_0061421 GO:2000042 biolink:BiologicalProcess negative regulation of double-strand break repair via homologous recombination Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination. go.json negative regulation of HDR|negative regulation of HRR|negative regulation of Rad51-dependent recombinational repair|negative regulation of Rhp51-dependent recombinational repair|negative regulation of homologous recombinational repair|negative regulation of homology-directed repair http://purl.obolibrary.org/obo/GO_2000042 GO:0036499 biolink:BiologicalProcess PERK-mediated unfolded protein response The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. go.json EIF2AK3-mediated unfolded protein response|PERK branch of UPR|PERK signal transduction pathway|PERK signaling in response to endoplasmic reticulum stress|PKR-like ER kinase signal transduction|UPR signaling by PERK stress sensor|endoplasmic reticulum unfolded protein response; PERK signaling|eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response http://purl.obolibrary.org/obo/GO_0036499 GO:2000043 biolink:BiologicalProcess regulation of cardiac cell fate specification Any process that modulates the frequency, rate or extent of cardiac cell fate specification. go.json http://purl.obolibrary.org/obo/GO_2000043 GO:0061422 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0. go.json positive regulation of transcription from RNA polymerase II promoter in response to alkalinity True http://purl.obolibrary.org/obo/GO_0061422 GO:0061423 biolink:BiologicalProcess obsolete positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json True http://purl.obolibrary.org/obo/GO_0061423 GO:2000044 biolink:BiologicalProcess negative regulation of cardiac cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification. go.json http://purl.obolibrary.org/obo/GO_2000044 GO:2000045 biolink:BiologicalProcess regulation of G1/S transition of mitotic cell cycle Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_2000045 GO:0061424 biolink:BiologicalProcess obsolete positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization. go.json positive regulation of peroxisome organisation by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0061424 GO:2000046 biolink:BiologicalProcess obsolete regulation of G2 phase of mitotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle. go.json regulation of G2 phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2000046 GO:0061425 biolink:BiologicalProcess positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process. go.json http://purl.obolibrary.org/obo/GO_0061425 GO:2000047 biolink:BiologicalProcess regulation of cell-cell adhesion mediated by cadherin Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. go.json http://purl.obolibrary.org/obo/GO_2000047 GO:0061426 biolink:BiologicalProcess obsolete positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport. go.json True http://purl.obolibrary.org/obo/GO_0061426 GO:2000048 biolink:BiologicalProcess negative regulation of cell-cell adhesion mediated by cadherin Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin. go.json http://purl.obolibrary.org/obo/GO_2000048 GO:0061427 biolink:BiologicalProcess obsolete negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0061427 GO:0061428 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. go.json http://purl.obolibrary.org/obo/GO_0061428 GO:0036490 biolink:BiologicalProcess regulation of translation in response to endoplasmic reticulum stress Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. go.json regulation of translation in response to ER stress http://purl.obolibrary.org/obo/GO_0036490 GO:0061429 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter by oleic acid Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_0061429 GO:0036491 biolink:BiologicalProcess regulation of translation initiation in response to endoplasmic reticulum stress Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress. go.json regulation of translation initiation in response to ER stress http://purl.obolibrary.org/obo/GO_0036491 GO:0036492 biolink:BiologicalProcess eiF2alpha phosphorylation in response to endoplasmic reticulum stress The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. go.json eiF2alpha phosphorylation in response to ER stress|regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_0036492 gocheck_do_not_annotate GO:0036493 biolink:BiologicalProcess positive regulation of translation in response to endoplasmic reticulum stress Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. go.json positive regulation of translation in response to ER stress http://purl.obolibrary.org/obo/GO_0036493 GO:0036494 biolink:BiologicalProcess positive regulation of translation initiation in response to endoplasmic reticulum stress Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress. go.json positive regulation of translation initiation in response to ER stress http://purl.obolibrary.org/obo/GO_0036494 GO:0036495 biolink:BiologicalProcess negative regulation of translation initiation in response to endoplasmic reticulum stress Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress. go.json negative regulation of translation initiation in response to ER stress http://purl.obolibrary.org/obo/GO_0036495 GO:2000040 biolink:BiologicalProcess regulation of planar cell polarity pathway involved in axis elongation Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation. go.json http://purl.obolibrary.org/obo/GO_2000040 GO:0036496 biolink:BiologicalProcess regulation of translational initiation by eIF2 alpha dephosphorylation Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha. go.json http://purl.obolibrary.org/obo/GO_0036496 gocheck_do_not_annotate GO:0120208 biolink:CellularComponent telodendria Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons. go.json http://purl.obolibrary.org/obo/GO_0120208 GO:0120209 biolink:CellularComponent cone telodendria Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina. go.json http://purl.obolibrary.org/obo/GO_0120209 GO:0120204 biolink:MolecularActivity methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2. go.json http://purl.obolibrary.org/obo/GO_0120204 GO:0120205 biolink:CellularComponent photoreceptor proximal connecting cilium The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR. go.json PCC|photoreceptor PCC http://purl.obolibrary.org/obo/GO_0120205 GO:0120206 biolink:CellularComponent photoreceptor distal connecting cilium The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability. go.json DCC|photoreceptor DCC http://purl.obolibrary.org/obo/GO_0120206 GO:0120207 biolink:BiologicalProcess endocytosis, site selection The process of selecting and or marking the position where endocytosis will occur. go.json http://purl.obolibrary.org/obo/GO_0120207 GO:2000052 biolink:BiologicalProcess positive regulation of non-canonical Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. go.json positive regulation of beta-catenin-independent Wnt receptor signaling pathway|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of non-canonical Wnt receptor signalling pathway|positive regulation of non-canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_2000052 GO:0036486 biolink:BiologicalProcess ventral trunk neural crest cell migration The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta. go.json trunk NCC migration through anterior sclerotome|trunk NCC migration within somite|ventral trunk NCC migration http://purl.obolibrary.org/obo/GO_0036486 GO:0120200 biolink:CellularComponent rod photoreceptor outer segment The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. go.json http://purl.obolibrary.org/obo/GO_0120200 GO:0120201 biolink:CellularComponent cone photoreceptor disc membrane Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane. go.json http://purl.obolibrary.org/obo/GO_0120201 GO:0036487 biolink:MolecularActivity nitric-oxide synthase inhibitor activity Binds to and stops, prevents or reduces the activity of nitric oxide synthase. go.json NOS inhibitor activity|nitric oxide synthase inhibitor activity http://purl.obolibrary.org/obo/GO_0036487 GO:2000053 biolink:BiologicalProcess regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. go.json regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification|regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification http://purl.obolibrary.org/obo/GO_2000053 GO:0061410 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to ethanol OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus. go.json True http://purl.obolibrary.org/obo/GO_0061410 GO:0120202 biolink:CellularComponent rod photoreceptor disc membrane Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment. go.json http://purl.obolibrary.org/obo/GO_0120202 GO:0036488 biolink:CellularComponent CHOP-C/EBP complex A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors. go.json CHOP-C/EBP dimer|CHOP-C/EBP heterodimer|GADD153-C/EBP complex|GADD153-C/EBP-alpha complex http://purl.obolibrary.org/obo/GO_0036488 GO:2000054 biolink:BiologicalProcess negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. go.json negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification|negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification http://purl.obolibrary.org/obo/GO_2000054 GO:0061411 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to cold Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. go.json http://purl.obolibrary.org/obo/GO_0061411 GO:0120203 biolink:CellularComponent rod photoreceptor disc lumen The volume enclosed by the membrane of a rod photoreceptor cell disc membrane. go.json http://purl.obolibrary.org/obo/GO_0120203 GO:0036489 biolink:BiologicalProcess neuromelanin biosynthetic process The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers. go.json neuromelanin anabolism|neuromelanin biosynthesis|neuromelanin formation|neuromelanin synthesis http://purl.obolibrary.org/obo/GO_0036489 GO:2000055 biolink:BiologicalProcess positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. go.json positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification|positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification http://purl.obolibrary.org/obo/GO_2000055 GO:0061412 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids. go.json True http://purl.obolibrary.org/obo/GO_0061412 GO:0061413 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. go.json http://purl.obolibrary.org/obo/GO_0061413 GO:2000056 biolink:BiologicalProcess regulation of Wnt signaling pathway involved in digestive tract morphogenesis Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. go.json regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis|regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis|regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis http://purl.obolibrary.org/obo/GO_2000056 GO:2000057 biolink:BiologicalProcess negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. go.json negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis|negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis|negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis http://purl.obolibrary.org/obo/GO_2000057 GO:0061414 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. go.json http://purl.obolibrary.org/obo/GO_0061414 GO:2000058 biolink:BiologicalProcess regulation of ubiquitin-dependent protein catabolic process Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process. go.json regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown|regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process|regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism|regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation|regulation of protein degradation tagging activity|regulation of protein ubiquitination during ubiquitin-dependent protein breakdown|regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination during ubiquitin-dependent protein catabolism|regulation of protein ubiquitination during ubiquitin-dependent protein degradation|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process|regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism|regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process|regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism http://purl.obolibrary.org/obo/GO_2000058 GO:0061415 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. go.json http://purl.obolibrary.org/obo/GO_0061415 GO:2000059 biolink:BiologicalProcess negative regulation of ubiquitin-dependent protein catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process. go.json negative regulation of protein degradation tagging activity|negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown|negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism|negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism|negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism http://purl.obolibrary.org/obo/GO_2000059 GO:0061416 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to salt stress OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json True http://purl.obolibrary.org/obo/GO_0061416 GO:0061417 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0061417 GO:0061418 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. go.json http://purl.obolibrary.org/obo/GO_0061418 GO:0036480 biolink:BiologicalProcess neuron intrinsic apoptotic signaling pathway in response to oxidative stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. go.json neuron apoptosis in response to oxidative stress|oxidative stress-induced neuron apoptosis|oxidative stress-induced neuronal apoptosis http://purl.obolibrary.org/obo/GO_0036480 GO:0061419 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. go.json http://purl.obolibrary.org/obo/GO_0061419 GO:0036481 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to hydrogen peroxide The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). go.json H2O2-induced intrinsic apoptotic signaling pathway|hydrogen peroxide-induced apoptosis|hydrogen peroxide-induced intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway in response to H2O2 http://purl.obolibrary.org/obo/GO_0036481 GO:0036482 biolink:BiologicalProcess neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide. go.json H2O2-induced neuron intrinsic apoptotic signaling pathway|hydrogen peroxide-induced neuron apoptosis|hydrogen peroxide-induced neuronal apoptosis|neuron apoptosis in response to hydrogen peroxide|neuron intrinsic apoptotic signaling pathway in response to H2O2 http://purl.obolibrary.org/obo/GO_0036482 GO:0036483 biolink:BiologicalProcess neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. go.json ER stress-induced neuron apoptosis|ER stress-induced neuron intrinsic apoptotic signaling pathway|endoplasmic reticulum stress-induced neuron apoptosis|endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_0036483 GO:2000050 biolink:BiologicalProcess regulation of non-canonical Wnt signaling pathway Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. go.json regulation of beta-catenin-independent Wnt receptor signaling pathway|regulation of non-canonical Wnt receptor signaling pathway|regulation of non-canonical Wnt receptor signalling pathway|regulation of non-canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_2000050 GO:0036484 biolink:BiologicalProcess trunk neural crest cell migration The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. go.json trunk NCC migration http://purl.obolibrary.org/obo/GO_0036484 GO:0036485 biolink:BiologicalProcess dorsolateral trunk neural crest cell migration The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells. go.json dorsolateral trunk NCC migration http://purl.obolibrary.org/obo/GO_0036485 GO:2000051 biolink:BiologicalProcess negative regulation of non-canonical Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway. go.json negative regulation of beta-catenin-independent Wnt receptor signaling pathway|negative regulation of non-canonical Wnt receptor signaling pathway|negative regulation of non-canonical Wnt receptor signalling pathway|negative regulation of non-canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_2000051 GO:1901329 biolink:BiologicalProcess regulation of odontoblast differentiation Any process that modulates the frequency, rate or extent of odontoblast differentiation. go.json http://purl.obolibrary.org/obo/GO_1901329 GO:1901327 biolink:BiologicalProcess response to tacrolimus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus. go.json response to FK506|response to tacrolimus hydrate http://purl.obolibrary.org/obo/GO_1901327 GO:1901328 biolink:BiologicalProcess response to cytochalasin B Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus. go.json http://purl.obolibrary.org/obo/GO_1901328 GO:1901325 biolink:BiologicalProcess response to antimycin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus. go.json http://purl.obolibrary.org/obo/GO_1901325 GO:1901326 biolink:BiologicalProcess response to tetracycline Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus. go.json http://purl.obolibrary.org/obo/GO_1901326 GO:1901323 biolink:BiologicalProcess response to erythromycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901323 GO:1901324 biolink:BiologicalProcess response to trichodermin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901324 GO:1901321 biolink:BiologicalProcess positive regulation of heart induction Any process that activates or increases the frequency, rate or extent of heart induction. go.json activation of heart induction|up regulation of heart induction|up-regulation of heart induction|upregulation of heart induction http://purl.obolibrary.org/obo/GO_1901321 GO:0061560 biolink:BiologicalProcess cranial ganglion formation The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. go.json cranial ganglia formation http://purl.obolibrary.org/obo/GO_0061560 GO:1901322 biolink:BiologicalProcess response to chloramphenicol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus. go.json http://purl.obolibrary.org/obo/GO_1901322 GO:0061561 biolink:BiologicalProcess trigeminal ganglion formation The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. go.json trigeminal ganglia formation http://purl.obolibrary.org/obo/GO_0061561 GO:0061562 biolink:BiologicalProcess cranial ganglion structural organization The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure. go.json cranial ganglia structural organization http://purl.obolibrary.org/obo/GO_0061562 GO:1901320 biolink:BiologicalProcess negative regulation of heart induction Any process that stops, prevents or reduces the frequency, rate or extent of heart induction. go.json down regulation of heart induction|down-regulation of heart induction|downregulation of heart induction|inhibition of heart induction http://purl.obolibrary.org/obo/GO_1901320 GO:0061563 biolink:BiologicalProcess trigeminal ganglion structural organization The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure. go.json trigeminal ganglia organization http://purl.obolibrary.org/obo/GO_0061563 GO:0061564 biolink:BiologicalProcess axon development The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation). go.json http://purl.obolibrary.org/obo/GO_0061564 GO:0061565 biolink:BiologicalProcess dAMP phosphorylation The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP. go.json http://purl.obolibrary.org/obo/GO_0061565 GO:0061566 biolink:BiologicalProcess CMP phosphorylation The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP. go.json http://purl.obolibrary.org/obo/GO_0061566 GO:0061567 biolink:BiologicalProcess dCMP phosphorylation The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP. go.json http://purl.obolibrary.org/obo/GO_0061567 GO:0061568 biolink:BiologicalProcess obsolete GDP phosphorylation OBSOLETE. The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP. go.json True http://purl.obolibrary.org/obo/GO_0061568 GO:0061569 biolink:BiologicalProcess obsolete UDP phosphorylation OBSOLETE. The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP. go.json True http://purl.obolibrary.org/obo/GO_0061569 GO:1901338 biolink:MolecularActivity catecholamine binding Binding to catecholamine. go.json http://purl.obolibrary.org/obo/GO_1901338 GO:1901339 biolink:BiologicalProcess regulation of store-operated calcium channel activity Any process that modulates the frequency, rate or extent of store-operated calcium channel activity. go.json http://purl.obolibrary.org/obo/GO_1901339 gocheck_do_not_annotate GO:1901336 biolink:BiologicalProcess lactone biosynthetic process The chemical reactions and pathways resulting in the formation of lactone. go.json lactone anabolism|lactone biosynthesis|lactone formation|lactone synthesis http://purl.obolibrary.org/obo/GO_1901336 GO:1901337 biolink:BiologicalProcess thioester transport The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901337 GO:1901334 biolink:BiologicalProcess lactone metabolic process The chemical reactions and pathways involving lactone. go.json lactone metabolism http://purl.obolibrary.org/obo/GO_1901334 GO:1901335 biolink:BiologicalProcess lactone catabolic process The chemical reactions and pathways resulting in the breakdown of lactone. go.json lactone breakdown|lactone catabolism|lactone degradation http://purl.obolibrary.org/obo/GO_1901335 GO:1901332 biolink:BiologicalProcess negative regulation of lateral root development Any process that stops, prevents or reduces the frequency, rate or extent of lateral root development. go.json down regulation of lateral root development|down-regulation of lateral root development|downregulation of lateral root development|inhibition of lateral root development http://purl.obolibrary.org/obo/GO_1901332 GO:1901333 biolink:BiologicalProcess positive regulation of lateral root development Any process that activates or increases the frequency, rate or extent of lateral root development. go.json activation of lateral root development|up regulation of lateral root development|up-regulation of lateral root development|upregulation of lateral root development http://purl.obolibrary.org/obo/GO_1901333 GO:0061550 biolink:BiologicalProcess cranial ganglion development The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. go.json cranial ganglia development http://purl.obolibrary.org/obo/GO_0061550 GO:1901330 biolink:BiologicalProcess negative regulation of odontoblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation. go.json down regulation of odontoblast differentiation|down-regulation of odontoblast differentiation|downregulation of odontoblast differentiation|inhibition of odontoblast differentiation http://purl.obolibrary.org/obo/GO_1901330 GO:1901331 biolink:BiologicalProcess positive regulation of odontoblast differentiation Any process that activates or increases the frequency, rate or extent of odontoblast differentiation. go.json activation of odontoblast differentiation|up regulation of odontoblast differentiation|up-regulation of odontoblast differentiation|upregulation of odontoblast differentiation http://purl.obolibrary.org/obo/GO_1901331 GO:0061551 biolink:BiologicalProcess trigeminal ganglion development The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. go.json trigeminal ganglia development http://purl.obolibrary.org/obo/GO_0061551 GO:0061552 biolink:BiologicalProcess ganglion morphogenesis The process in which the anatomical structures of ganglion are generated and organized. go.json ganglia morphogenesis http://purl.obolibrary.org/obo/GO_0061552 GO:0061553 biolink:BiologicalProcess ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. go.json ganglia maturation http://purl.obolibrary.org/obo/GO_0061553 GO:1901340 biolink:BiologicalProcess negative regulation of store-operated calcium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity. go.json down regulation of store-operated calcium channel activity|down-regulation of store-operated calcium channel activity|downregulation of store-operated calcium channel activity|inhibition of store-operated calcium channel activity http://purl.obolibrary.org/obo/GO_1901340 gocheck_do_not_annotate GO:0061554 biolink:BiologicalProcess ganglion formation The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. go.json ganglia formation http://purl.obolibrary.org/obo/GO_0061554 GO:0061555 biolink:BiologicalProcess ganglion structural organization The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure. go.json ganglia structural organization http://purl.obolibrary.org/obo/GO_0061555 GO:0061556 biolink:BiologicalProcess trigeminal ganglion morphogenesis The process in which the anatomical structure of a trigeminal ganglion is generated and organized. go.json trigeminal ganglia morphogenesis http://purl.obolibrary.org/obo/GO_0061556 GO:0061557 biolink:BiologicalProcess trigeminal ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. go.json trigeminal ganglia maturation http://purl.obolibrary.org/obo/GO_0061557 GO:0061558 biolink:BiologicalProcess cranial ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. go.json cranial ganglia maturation http://purl.obolibrary.org/obo/GO_0061558 GO:0061559 biolink:BiologicalProcess cranial ganglion morphogenesis The process in which the anatomical structure of a cranial ganglion is generated and organized. go.json cranial ganglia morphogenesis http://purl.obolibrary.org/obo/GO_0061559 GO:1901349 biolink:BiologicalProcess glucosinolate transport The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901349 GO:1901347 biolink:BiologicalProcess negative regulation of secondary cell wall biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell wall biogenesis. go.json down regulation of cellulose and pectin-containing secondary cell wall biogenesis|down regulation of plant-type secondary cell wall biogenesis|down regulation of secondary cell wall anabolism|down regulation of secondary cell wall biogenesis|down regulation of secondary cell wall biosynthetic process|down regulation of secondary cell wall formation|down regulation of secondary cell wall synthesis|down-regulation of cellulose and pectin-containing secondary cell wall biogenesis|down-regulation of plant-type secondary cell wall biogenesis|down-regulation of secondary cell wall anabolism|down-regulation of secondary cell wall biogenesis|down-regulation of secondary cell wall biosynthetic process|down-regulation of secondary cell wall formation|down-regulation of secondary cell wall synthesis|downregulation of cellulose and pectin-containing secondary cell wall biogenesis|downregulation of plant-type secondary cell wall biogenesis|downregulation of secondary cell wall anabolism|downregulation of secondary cell wall biogenesis|downregulation of secondary cell wall biosynthetic process|downregulation of secondary cell wall formation|downregulation of secondary cell wall synthesis|inhibition of cellulose and pectin-containing secondary cell wall biogenesis|inhibition of plant-type secondary cell wall biogenesis|inhibition of secondary cell wall anabolism|inhibition of secondary cell wall biogenesis|inhibition of secondary cell wall biosynthetic process|inhibition of secondary cell wall formation|inhibition of secondary cell wall synthesis|negative regulation of cellulose and pectin-containing secondary cell wall biogenesis|negative regulation of plant-type secondary cell wall biogenesis|negative regulation of secondary cell wall anabolism|negative regulation of secondary cell wall biosynthetic process|negative regulation of secondary cell wall formation|negative regulation of secondary cell wall synthesis http://purl.obolibrary.org/obo/GO_1901347 GO:1901348 biolink:BiologicalProcess positive regulation of secondary cell wall biogenesis Any process that activates or increases the frequency, rate or extent of secondary cell wall biogenesis. go.json activation of cellulose and pectin-containing secondary cell wall biogenesis|activation of plant-type secondary cell wall biogenesis|activation of secondary cell wall anabolism|activation of secondary cell wall biogenesis|activation of secondary cell wall biosynthetic process|activation of secondary cell wall formation|activation of secondary cell wall synthesis|positive regulation of cellulose and pectin-containing secondary cell wall biogenesis|positive regulation of plant-type secondary cell wall biogenesis|positive regulation of secondary cell wall anabolism|positive regulation of secondary cell wall biosynthetic process|positive regulation of secondary cell wall formation|positive regulation of secondary cell wall synthesis|up regulation of cellulose and pectin-containing secondary cell wall biogenesis|up regulation of plant-type secondary cell wall biogenesis|up regulation of secondary cell wall anabolism|up regulation of secondary cell wall biogenesis|up regulation of secondary cell wall biosynthetic process|up regulation of secondary cell wall formation|up regulation of secondary cell wall synthesis|up-regulation of cellulose and pectin-containing secondary cell wall biogenesis|up-regulation of plant-type secondary cell wall biogenesis|up-regulation of secondary cell wall anabolism|up-regulation of secondary cell wall biogenesis|up-regulation of secondary cell wall biosynthetic process|up-regulation of secondary cell wall formation|up-regulation of secondary cell wall synthesis|upregulation of cellulose and pectin-containing secondary cell wall biogenesis|upregulation of plant-type secondary cell wall biogenesis|upregulation of secondary cell wall anabolism|upregulation of secondary cell wall biogenesis|upregulation of secondary cell wall biosynthetic process|upregulation of secondary cell wall formation|upregulation of secondary cell wall synthesis http://purl.obolibrary.org/obo/GO_1901348 GO:1901345 biolink:BiologicalProcess response to L-thialysine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus. go.json response to thialysine http://purl.obolibrary.org/obo/GO_1901345 GO:1901346 biolink:BiologicalProcess negative regulation of vasculature development involved in avascular cornea development in camera-type eye Any negative regulation of vasculature development that is involved in developing an avascular cornea of a camera-type eye. go.json down regulation of vascular system development involved in avascular cornea development|down regulation of vascular system development involved in avascular cornea development in camera-type eye|down regulation of vasculature development involved in avascular cornea development|down regulation of vasculature development involved in avascular cornea development in camera-type eye|down-regulation of vascular system development involved in avascular cornea development|down-regulation of vascular system development involved in avascular cornea development in camera-type eye|down-regulation of vasculature development involved in avascular cornea development|down-regulation of vasculature development involved in avascular cornea development in camera-type eye|downregulation of vascular system development involved in avascular cornea development|downregulation of vascular system development involved in avascular cornea development in camera-type eye|downregulation of vasculature development involved in avascular cornea development|downregulation of vasculature development involved in avascular cornea development in camera-type eye|inhibition of vascular system development involved in avascular cornea development|inhibition of vascular system development involved in avascular cornea development in camera-type eye|inhibition of vasculature development involved in avascular cornea development|inhibition of vasculature development involved in avascular cornea development in camera-type eye|negative regulation of vascular system development involved in avascular cornea development|negative regulation of vascular system development involved in avascular cornea development in camera-type eye|negative regulation of vasculature development involved in avascular cornea development http://purl.obolibrary.org/obo/GO_1901346 GO:0061580 biolink:BiologicalProcess colon epithelial cell migration The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0061580 GO:1901343 biolink:BiologicalProcess negative regulation of vasculature development Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. go.json down regulation of vascular system development|down regulation of vasculature development|down-regulation of vascular system development|down-regulation of vasculature development|downregulation of vascular system development|downregulation of vasculature development|inhibition of vascular system development|inhibition of vasculature development|negative regulation of vascular system development http://purl.obolibrary.org/obo/GO_1901343 GO:0061581 biolink:BiologicalProcess corneal epithelial cell migration The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0061581 GO:0061582 biolink:BiologicalProcess intestinal epithelial cell migration The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0061582 GO:1901344 biolink:BiologicalProcess response to leptomycin B Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus. go.json http://purl.obolibrary.org/obo/GO_1901344 GO:0061583 biolink:BiologicalProcess colon epithelial cell chemotaxis The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_0061583 GO:1901341 biolink:BiologicalProcess positive regulation of store-operated calcium channel activity Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity. go.json activation of store-operated calcium channel activity|up regulation of store-operated calcium channel activity|up-regulation of store-operated calcium channel activity|upregulation of store-operated calcium channel activity http://purl.obolibrary.org/obo/GO_1901341 gocheck_do_not_annotate GO:1901342 biolink:BiologicalProcess regulation of vasculature development Any process that modulates the frequency, rate or extent of vasculature development. go.json regulation of vascular system development http://purl.obolibrary.org/obo/GO_1901342 GO:0061584 biolink:BiologicalProcess orexin secretion The controlled release of orexin from a cell or a tissue. go.json hypocretin secretion http://purl.obolibrary.org/obo/GO_0061584 GO:1901350 biolink:BiologicalProcess obsolete cell-cell signaling involved in cell-cell junction organization OBSOLETE. Any cell-cell signaling that is involved in cell-cell junction organization. go.json cell-cell signaling involved in cell-cell junction assembly and maintenance|cell-cell signaling involved in cell-cell junction biogenesis|cell-cell signaling involved in cell-cell junction organisation|cell-cell signaling involved in intercellular junction assembly and maintenance|cell-cell signalling involved in cell-cell junction assembly and maintenance|cell-cell signalling involved in cell-cell junction biogenesis|cell-cell signalling involved in cell-cell junction organisation|cell-cell signalling involved in cell-cell junction organization|cell-cell signalling involved in intercellular junction assembly and maintenance True http://purl.obolibrary.org/obo/GO_1901350 GO:0061585 biolink:BiologicalProcess orexin secretion, neurotransmission The controlled release of orexin from a cell in which orexin acts as a neurotransmitter. go.json hypocretin secretion, neurotransmission http://purl.obolibrary.org/obo/GO_0061585 GO:1901351 biolink:BiologicalProcess regulation of phosphatidylglycerol biosynthetic process Any process that modulates the frequency, rate or extent of phosphatidylglycerol biosynthetic process. go.json regulation of phosphatidylglycerol anabolism|regulation of phosphatidylglycerol biosynthesis|regulation of phosphatidylglycerol formation|regulation of phosphatidylglycerol synthesis http://purl.obolibrary.org/obo/GO_1901351 GO:0061586 biolink:BiologicalProcess positive regulation of transcription by transcription factor localization Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. go.json http://purl.obolibrary.org/obo/GO_0061586 GO:0061587 biolink:BiologicalProcess obsolete tRNA locus-associated negative regulation of gene expression OBSOLETE. The chromatin silencing process that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes. go.json tDNA-mediated gene silencing|tRNA gene-mediated chromatin silencing|tRNA gene-mediated gene silencing|tgm silencing|transfer RNA gene-mediated chromatin silencing|transfer RNA gene-mediated gene silencing|transfer RNA gene-mediated silencinga True http://purl.obolibrary.org/obo/GO_0061587 GO:0061588 biolink:BiologicalProcess calcium activated phospholipid scrambling The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. go.json http://purl.obolibrary.org/obo/GO_0061588 GO:0061589 biolink:BiologicalProcess calcium activated phosphatidylserine scrambling The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. go.json http://purl.obolibrary.org/obo/GO_0061589 GO:1901358 biolink:BiologicalProcess beta-D-galactofuranose biosynthetic process The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose. go.json beta-D-galactofuranose anabolism|beta-D-galactofuranose biosynthesis|beta-D-galactofuranose formation|beta-D-galactofuranose synthesis http://purl.obolibrary.org/obo/GO_1901358 GO:1901359 biolink:MolecularActivity tungstate binding Binding to tungstate. go.json http://purl.obolibrary.org/obo/GO_1901359 GO:1901356 biolink:BiologicalProcess beta-D-galactofuranose metabolic process The chemical reactions and pathways involving beta-D-galactofuranose. go.json beta-D-galactofuranose metabolism http://purl.obolibrary.org/obo/GO_1901356 GO:1901357 biolink:BiologicalProcess beta-D-galactofuranose catabolic process The chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose. go.json beta-D-galactofuranose breakdown|beta-D-galactofuranose catabolism|beta-D-galactofuranose degradation http://purl.obolibrary.org/obo/GO_1901357 GO:0061570 biolink:BiologicalProcess obsolete dCDP phosphorylation OBSOLETE. The process of introducing a phosphate group into dCDP to produce a dCTP. go.json True http://purl.obolibrary.org/obo/GO_0061570 GO:1901354 biolink:BiologicalProcess response to L-canavanine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. go.json http://purl.obolibrary.org/obo/GO_1901354 GO:0061571 biolink:BiologicalProcess obsolete TDP phosphorylation OBSOLETE. The process of introducing a phosphate group into TDP to produce a TTP. go.json True http://purl.obolibrary.org/obo/GO_0061571 GO:1901355 biolink:BiologicalProcess response to rapamycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901355 GO:1901352 biolink:BiologicalProcess negative regulation of phosphatidylglycerol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process. go.json down regulation of phosphatidylglycerol anabolism|down regulation of phosphatidylglycerol biosynthesis|down regulation of phosphatidylglycerol biosynthetic process|down regulation of phosphatidylglycerol formation|down regulation of phosphatidylglycerol synthesis|down-regulation of phosphatidylglycerol anabolism|down-regulation of phosphatidylglycerol biosynthesis|down-regulation of phosphatidylglycerol biosynthetic process|down-regulation of phosphatidylglycerol formation|down-regulation of phosphatidylglycerol synthesis|downregulation of phosphatidylglycerol anabolism|downregulation of phosphatidylglycerol biosynthesis|downregulation of phosphatidylglycerol biosynthetic process|downregulation of phosphatidylglycerol formation|downregulation of phosphatidylglycerol synthesis|inhibition of phosphatidylglycerol anabolism|inhibition of phosphatidylglycerol biosynthesis|inhibition of phosphatidylglycerol biosynthetic process|inhibition of phosphatidylglycerol formation|inhibition of phosphatidylglycerol synthesis|negative regulation of phosphatidylglycerol anabolism|negative regulation of phosphatidylglycerol biosynthesis|negative regulation of phosphatidylglycerol formation|negative regulation of phosphatidylglycerol synthesis http://purl.obolibrary.org/obo/GO_1901352 GO:0061572 biolink:BiologicalProcess actin filament bundle organization A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. go.json actin filament cable organization http://purl.obolibrary.org/obo/GO_0061572 GO:0061573 biolink:BiologicalProcess actin filament bundle retrograde transport A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell. go.json actin filament cable retrograde transport http://purl.obolibrary.org/obo/GO_0061573 GO:1901353 biolink:BiologicalProcess positive regulation of phosphatidylglycerol biosynthetic process Any process that activates or increases the frequency, rate or extent of phosphatidylglycerol biosynthetic process. go.json activation of phosphatidylglycerol anabolism|activation of phosphatidylglycerol biosynthesis|activation of phosphatidylglycerol biosynthetic process|activation of phosphatidylglycerol formation|activation of phosphatidylglycerol synthesis|positive regulation of phosphatidylglycerol anabolism|positive regulation of phosphatidylglycerol biosynthesis|positive regulation of phosphatidylglycerol formation|positive regulation of phosphatidylglycerol synthesis|up regulation of phosphatidylglycerol anabolism|up regulation of phosphatidylglycerol biosynthesis|up regulation of phosphatidylglycerol biosynthetic process|up regulation of phosphatidylglycerol formation|up regulation of phosphatidylglycerol synthesis|up-regulation of phosphatidylglycerol anabolism|up-regulation of phosphatidylglycerol biosynthesis|up-regulation of phosphatidylglycerol biosynthetic process|up-regulation of phosphatidylglycerol formation|up-regulation of phosphatidylglycerol synthesis|upregulation of phosphatidylglycerol anabolism|upregulation of phosphatidylglycerol biosynthesis|upregulation of phosphatidylglycerol biosynthetic process|upregulation of phosphatidylglycerol formation|upregulation of phosphatidylglycerol synthesis http://purl.obolibrary.org/obo/GO_1901353 GO:1901361 biolink:BiologicalProcess organic cyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. go.json organic cyclic compound breakdown|organic cyclic compound catabolism|organic cyclic compound degradation http://purl.obolibrary.org/obo/GO_1901361 GO:0061574 biolink:CellularComponent ASAP complex A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1. go.json http://purl.obolibrary.org/obo/GO_0061574 GO:0061575 biolink:MolecularActivity cyclin-dependent protein serine/threonine kinase activator activity Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. go.json cyclin-dependent protein kinase 5 activator activity http://purl.obolibrary.org/obo/GO_0061575 GO:1901362 biolink:BiologicalProcess organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. go.json organic cyclic compound anabolism|organic cyclic compound biosynthesis|organic cyclic compound formation|organic cyclic compound synthesis http://purl.obolibrary.org/obo/GO_1901362 GO:0061576 biolink:CellularComponent acyl-CoA ceramide synthase complex A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1. go.json http://purl.obolibrary.org/obo/GO_0061576 GO:1901360 biolink:BiologicalProcess organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound. go.json organic cyclic compound metabolism http://purl.obolibrary.org/obo/GO_1901360 GO:0061577 biolink:BiologicalProcess calcium ion transmembrane transport via high voltage-gated calcium channel A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel. go.json generation of L-type calcium current http://purl.obolibrary.org/obo/GO_0061577 GO:0061578 biolink:MolecularActivity K63-linked deubiquitinase activity Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin. Reactome:R-HSA-5357845|Reactome:R-HSA-5690856|Reactome:R-HSA-5691411|Reactome:R-HSA-5691431|Reactome:R-HSA-5691439|Reactome:R-HSA-5696547|Reactome:R-HSA-688136|Reactome:R-HSA-741411|Reactome:R-HSA-8869506|Reactome:R-HSA-936381|Reactome:R-HSA-936390|Reactome:R-HSA-9685219|Reactome:R-HSA-9711016|Reactome:R-HSA-9750942|Reactome:R-HSA-9817400 go.json K63-specific deubiquitinase activity|Lys63-specific deubiquitinase activity http://purl.obolibrary.org/obo/GO_0061578 GO:0061579 biolink:MolecularActivity N-acyl homoserine lactone synthase activity Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone. EC:2.3.1.184|RHEA:10096 go.json autoinducer-1 synthase http://purl.obolibrary.org/obo/GO_0061579 GO:1901369 biolink:BiologicalProcess cyclic 2,3-bisphospho-D-glycerate biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid. go.json cDPG biosynthesis|cyclic 2,3-bisphospho-D-glyceric acid anabolism|cyclic 2,3-bisphospho-D-glyceric acid biosynthesis|cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process|cyclic 2,3-bisphospho-D-glyceric acid formation|cyclic 2,3-bisphospho-D-glyceric acid synthesis|cyclic 2,3-diphosphoglycerate biosynthesis http://purl.obolibrary.org/obo/GO_1901369 GO:1901367 biolink:BiologicalProcess response to L-cysteine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. go.json http://purl.obolibrary.org/obo/GO_1901367 GO:1901368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901368 GO:1901365 biolink:BiologicalProcess funalenone catabolic process The chemical reactions and pathways resulting in the breakdown of funalenone. go.json funalenone breakdown|funalenone catabolism|funalenone degradation http://purl.obolibrary.org/obo/GO_1901365 GO:1901366 biolink:BiologicalProcess funalenone biosynthetic process The chemical reactions and pathways resulting in the formation of funalenone. go.json funalenone anabolism|funalenone biosynthesis|funalenone formation|funalenone synthesis http://purl.obolibrary.org/obo/GO_1901366 GO:1901363 biolink:MolecularActivity heterocyclic compound binding Binding to heterocyclic compound. go.json http://purl.obolibrary.org/obo/GO_1901363 GO:1901364 biolink:BiologicalProcess funalenone metabolic process The chemical reactions and pathways involving funalenone. go.json funalenone metabolism http://purl.obolibrary.org/obo/GO_1901364 GO:1901372 biolink:BiologicalProcess obsolete trehalose biosynthetic process involved in ascospore formation OBSOLETE. Any trehalose biosynthetic process that is involved in ascospore formation. go.json mycose biosynthesis involved in ascospore biosynthesis|mycose biosynthesis involved in ascospore formation|mycose biosynthetic process involved in ascospore biosynthesis|mycose biosynthetic process involved in ascospore formation|mykose biosynthesis involved in ascospore biosynthesis|mykose biosynthesis involved in ascospore formation|mykose biosynthetic process involved in ascospore biosynthesis|mykose biosynthetic process involved in ascospore formation|trehalose anabolism involved in ascospore biosynthesis|trehalose anabolism involved in ascospore formation|trehalose biosynthesis involved in ascospore biosynthesis|trehalose biosynthesis involved in ascospore formation|trehalose biosynthetic process involved in ascospore biosynthesis|trehalose formation involved in ascospore biosynthesis|trehalose formation involved in ascospore formation|trehalose synthesis involved in ascospore biosynthesis|trehalose synthesis involved in ascospore formation True http://purl.obolibrary.org/obo/GO_1901372 GO:1901373 biolink:BiologicalProcess lipid hydroperoxide transport The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901373 GO:1901370 biolink:BiologicalProcess response to glutathione Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus. go.json http://purl.obolibrary.org/obo/GO_1901370 GO:1901371 biolink:BiologicalProcess regulation of leaf morphogenesis Any process that modulates the frequency, rate or extent of leaf morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1901371 GO:1901378 biolink:BiologicalProcess organic heteropentacyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic heteropentacyclic compound. go.json organic heteropentacyclic compound anabolism|organic heteropentacyclic compound biosynthesis|organic heteropentacyclic compound formation|organic heteropentacyclic compound synthesis http://purl.obolibrary.org/obo/GO_1901378 GO:0061590 biolink:BiologicalProcess calcium activated phosphatidylcholine scrambling The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. go.json http://purl.obolibrary.org/obo/GO_0061590 GO:1901379 biolink:BiologicalProcess regulation of potassium ion transmembrane transport Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. go.json regulation of potassium ion membrane transport http://purl.obolibrary.org/obo/GO_1901379 GO:0061591 biolink:BiologicalProcess calcium activated galactosylceramide scrambling The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. go.json http://purl.obolibrary.org/obo/GO_0061591 GO:1901376 biolink:BiologicalProcess organic heteropentacyclic compound metabolic process The chemical reactions and pathways involving organic heteropentacyclic compound. go.json organic heteropentacyclic compound metabolism http://purl.obolibrary.org/obo/GO_1901376 GO:0061592 biolink:BiologicalProcess phosphatidylserine exposure on osteoblast involved in bone mineralization A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization. go.json http://purl.obolibrary.org/obo/GO_0061592 GO:1901377 biolink:BiologicalProcess organic heteropentacyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound. go.json organic heteropentacyclic compound breakdown|organic heteropentacyclic compound catabolism|organic heteropentacyclic compound degradation http://purl.obolibrary.org/obo/GO_1901377 GO:0061593 biolink:MolecularActivity sulfoquinovose isomerase activity Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose. go.json http://purl.obolibrary.org/obo/GO_0061593 GO:1901374 biolink:BiologicalProcess acetate ester transport The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901374 GO:0061594 biolink:MolecularActivity 6-deoxy-6-sulfofructose kinase activity Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP. EC:2.7.1.184|MetaCyc:RXN-15297|RHEA:40443 go.json http://purl.obolibrary.org/obo/GO_0061594 GO:1901375 biolink:MolecularActivity acetate ester transmembrane transporter activity Enables the transfer of an acetate ester from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901375 GO:0061595 biolink:MolecularActivity 6-deoxy-6-sulfofructose-1-phosphate aldolase activity Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate. go.json http://purl.obolibrary.org/obo/GO_0061595 GO:0061596 biolink:MolecularActivity 3-sulfolactaldehyde reductase activity Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+. EC:1.1.1.373|MetaCyc:RXN-15299|RHEA:40511 go.json http://purl.obolibrary.org/obo/GO_0061596 GO:1901383 biolink:BiologicalProcess negative regulation of chorionic trophoblast cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation. go.json down regulation of chorionic trophoblast cell proliferation|down-regulation of chorionic trophoblast cell proliferation|downregulation of chorionic trophoblast cell proliferation|inhibition of chorionic trophoblast cell proliferation http://purl.obolibrary.org/obo/GO_1901383 GO:0061597 biolink:MolecularActivity obsolete cyclic pyranopterin monophosphate synthase activity OBSOLETE. Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate. go.json True http://purl.obolibrary.org/obo/GO_0061597 GO:1901384 biolink:BiologicalProcess positive regulation of chorionic trophoblast cell proliferation Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation. go.json activation of chorionic trophoblast cell proliferation|up regulation of chorionic trophoblast cell proliferation|up-regulation of chorionic trophoblast cell proliferation|upregulation of chorionic trophoblast cell proliferation http://purl.obolibrary.org/obo/GO_1901384 GO:0061598 biolink:MolecularActivity molybdopterin adenylyltransferase activity Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin. EC:2.7.7.75|RHEA:31331 go.json http://purl.obolibrary.org/obo/GO_0061598 GO:1901381 biolink:BiologicalProcess positive regulation of potassium ion transmembrane transport Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. go.json activation of potassium ion transmembrane transport|positive regulation of potassium ion membrane transport|up regulation of potassium ion transmembrane transport|up-regulation of potassium ion transmembrane transport|upregulation of potassium ion transmembrane transport http://purl.obolibrary.org/obo/GO_1901381 GO:0061599 biolink:MolecularActivity molybdopterin molybdotransferase activity Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. EC:2.10.1.1|RHEA:35047|Reactome:R-HSA-947531 go.json http://purl.obolibrary.org/obo/GO_0061599 GO:1901382 biolink:BiologicalProcess regulation of chorionic trophoblast cell proliferation Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation. go.json http://purl.obolibrary.org/obo/GO_1901382 GO:1901380 biolink:BiologicalProcess negative regulation of potassium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. go.json down regulation of potassium ion transmembrane transport|down-regulation of potassium ion transmembrane transport|downregulation of potassium ion transmembrane transport|inhibition of potassium ion transmembrane transport|negative regulation of potassium ion membrane transport http://purl.obolibrary.org/obo/GO_1901380 GO:1901389 biolink:BiologicalProcess negative regulation of transforming growth factor beta activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation. go.json down regulation of L-TGF-beta activation|down regulation of TGF-B activation|down regulation of TGF-beta activation|down regulation of TGFB activation|down regulation of TGFbeta activation|down regulation of latent TGF-beta activation|down regulation of transforming growth factor beta activation|down-regulation of L-TGF-beta activation|down-regulation of TGF-B activation|down-regulation of TGF-beta activation|down-regulation of TGFB activation|down-regulation of TGFbeta activation|down-regulation of latent TGF-beta activation|down-regulation of transforming growth factor beta activation|downregulation of L-TGF-beta activation|downregulation of TGF-B activation|downregulation of TGF-beta activation|downregulation of TGFB activation|downregulation of TGFbeta activation|downregulation of latent TGF-beta activation|downregulation of transforming growth factor beta activation|inhibition of L-TGF-beta activation|inhibition of TGF-B activation|inhibition of TGF-beta activation|inhibition of TGFB activation|inhibition of TGFbeta activation|inhibition of latent TGF-beta activation|inhibition of transforming growth factor beta activation|negative regulation of L-TGF-beta activation|negative regulation of TGF-B activation|negative regulation of TGF-beta activation|negative regulation of TGFB activation|negative regulation of TGFbeta activation|negative regulation of latent TGF-beta activation http://purl.obolibrary.org/obo/GO_1901389 GO:1901387 biolink:BiologicalProcess positive regulation of voltage-gated calcium channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity. go.json activation of depolarization-activated calcium channel|activation of depolarization-activated voltage gated calcium channel activity|activation of depolarization-activated voltage-gated calcium channel|activation of depolarization-activated voltage-gated calcium channel activity|activation of dihydropyridine-sensitive calcium channel activity|activation of voltage gated calcium channel activity|activation of voltage-dependent calcium channel activity|activation of voltage-gated calcium channel activity|activation of voltage-gated calcium ion channel activity|activation of voltage-sensitive calcium channel|positive regulation of depolarization-activated calcium channel|positive regulation of depolarization-activated voltage gated calcium channel activity|positive regulation of depolarization-activated voltage-gated calcium channel|positive regulation of depolarization-activated voltage-gated calcium channel activity|positive regulation of dihydropyridine-sensitive calcium channel activity|positive regulation of voltage gated calcium channel activity|positive regulation of voltage-dependent calcium channel activity|positive regulation of voltage-gated calcium ion channel activity|positive regulation of voltage-sensitive calcium channel|up regulation of depolarization-activated calcium channel|up regulation of depolarization-activated voltage gated calcium channel activity|up regulation of depolarization-activated voltage-gated calcium channel|up regulation of depolarization-activated voltage-gated calcium channel activity|up regulation of dihydropyridine-sensitive calcium channel activity|up regulation of voltage gated calcium channel activity|up regulation of voltage-dependent calcium channel activity|up regulation of voltage-gated calcium channel activity|up regulation of voltage-gated calcium ion channel activity|up regulation of voltage-sensitive calcium channel|up-regulation of depolarization-activated calcium channel|up-regulation of depolarization-activated voltage gated calcium channel activity|up-regulation of depolarization-activated voltage-gated calcium channel|up-regulation of depolarization-activated voltage-gated calcium channel activity|up-regulation of dihydropyridine-sensitive calcium channel activity|up-regulation of voltage gated calcium channel activity|up-regulation of voltage-dependent calcium channel activity|up-regulation of voltage-gated calcium channel activity|up-regulation of voltage-gated calcium ion channel activity|up-regulation of voltage-sensitive calcium channel|upregulation of depolarization-activated calcium channel|upregulation of depolarization-activated voltage gated calcium channel activity|upregulation of depolarization-activated voltage-gated calcium channel|upregulation of depolarization-activated voltage-gated calcium channel activity|upregulation of dihydropyridine-sensitive calcium channel activity|upregulation of voltage gated calcium channel activity|upregulation of voltage-dependent calcium channel activity|upregulation of voltage-gated calcium channel activity|upregulation of voltage-gated calcium ion channel activity|upregulation of voltage-sensitive calcium channel http://purl.obolibrary.org/obo/GO_1901387 gocheck_do_not_annotate GO:1901388 biolink:BiologicalProcess regulation of transforming growth factor beta activation Any process that modulates the frequency, rate or extent of transforming growth factor beta activation. go.json regulation of L-TGF-beta activation|regulation of TGF-B activation|regulation of TGF-beta activation|regulation of TGFB activation|regulation of TGFbeta activation|regulation of latent TGF-beta activation http://purl.obolibrary.org/obo/GO_1901388 GO:1901385 biolink:BiologicalProcess regulation of voltage-gated calcium channel activity Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. go.json regulation of depolarization-activated calcium channel|regulation of depolarization-activated voltage gated calcium channel activity|regulation of depolarization-activated voltage-gated calcium channel|regulation of depolarization-activated voltage-gated calcium channel activity|regulation of dihydropyridine-sensitive calcium channel activity|regulation of voltage gated calcium channel activity|regulation of voltage-dependent calcium channel activity|regulation of voltage-gated calcium ion channel activity|regulation of voltage-sensitive calcium channel http://purl.obolibrary.org/obo/GO_1901385 gocheck_do_not_annotate GO:1901386 biolink:BiologicalProcess negative regulation of voltage-gated calcium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. go.json down regulation of depolarization-activated calcium channel|down regulation of depolarization-activated voltage gated calcium channel activity|down regulation of depolarization-activated voltage-gated calcium channel|down regulation of depolarization-activated voltage-gated calcium channel activity|down regulation of dihydropyridine-sensitive calcium channel activity|down regulation of voltage gated calcium channel activity|down regulation of voltage-dependent calcium channel activity|down regulation of voltage-gated calcium channel activity|down regulation of voltage-gated calcium ion channel activity|down regulation of voltage-sensitive calcium channel|down-regulation of depolarization-activated calcium channel|down-regulation of depolarization-activated voltage gated calcium channel activity|down-regulation of depolarization-activated voltage-gated calcium channel|down-regulation of depolarization-activated voltage-gated calcium channel activity|down-regulation of dihydropyridine-sensitive calcium channel activity|down-regulation of voltage gated calcium channel activity|down-regulation of voltage-dependent calcium channel activity|down-regulation of voltage-gated calcium channel activity|down-regulation of voltage-gated calcium ion channel activity|down-regulation of voltage-sensitive calcium channel|downregulation of depolarization-activated calcium channel|downregulation of depolarization-activated voltage gated calcium channel activity|downregulation of depolarization-activated voltage-gated calcium channel|downregulation of depolarization-activated voltage-gated calcium channel activity|downregulation of dihydropyridine-sensitive calcium channel activity|downregulation of voltage gated calcium channel activity|downregulation of voltage-dependent calcium channel activity|downregulation of voltage-gated calcium channel activity|downregulation of voltage-gated calcium ion channel activity|downregulation of voltage-sensitive calcium channel|inhibition of depolarization-activated calcium channel|inhibition of depolarization-activated voltage gated calcium channel activity|inhibition of depolarization-activated voltage-gated calcium channel|inhibition of depolarization-activated voltage-gated calcium channel activity|inhibition of dihydropyridine-sensitive calcium channel activity|inhibition of voltage gated calcium channel activity|inhibition of voltage-dependent calcium channel activity|inhibition of voltage-gated calcium channel activity|inhibition of voltage-gated calcium ion channel activity|inhibition of voltage-sensitive calcium channel|negative regulation of depolarization-activated calcium channel|negative regulation of depolarization-activated voltage gated calcium channel activity|negative regulation of depolarization-activated voltage-gated calcium channel|negative regulation of depolarization-activated voltage-gated calcium channel activity|negative regulation of dihydropyridine-sensitive calcium channel activity|negative regulation of voltage gated calcium channel activity|negative regulation of voltage-dependent calcium channel activity|negative regulation of voltage-gated calcium ion channel activity|negative regulation of voltage-sensitive calcium channel http://purl.obolibrary.org/obo/GO_1901386 gocheck_do_not_annotate GO:1901394 biolink:BiologicalProcess positive regulation of transforming growth factor beta1 activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation. go.json activation of L-TGF-beta 1 activation|activation of TGF-beta 1 activation|activation of TGFB1 activation|activation of TGFbeta 1 activation|activation of latent-TGF-beta1 activation|activation of transforming growth factor beta1 activation|activation of transforming growth factor-beta1 activation|positive regulation of L-TGF-beta 1 activation|positive regulation of TGF-beta 1 activation|positive regulation of TGFB1 activation|positive regulation of TGFbeta 1 activation|positive regulation of latent-TGF-beta1 activation|positive regulation of transforming growth factor-beta1 activation|up regulation of L-TGF-beta 1 activation|up regulation of TGF-beta 1 activation|up regulation of TGFB1 activation|up regulation of TGFbeta 1 activation|up regulation of latent-TGF-beta1 activation|up regulation of transforming growth factor beta1 activation|up regulation of transforming growth factor-beta1 activation|up-regulation of L-TGF-beta 1 activation|up-regulation of TGF-beta 1 activation|up-regulation of TGFB1 activation|up-regulation of TGFbeta 1 activation|up-regulation of latent-TGF-beta1 activation|up-regulation of transforming growth factor beta1 activation|up-regulation of transforming growth factor-beta1 activation|upregulation of L-TGF-beta 1 activation|upregulation of TGF-beta 1 activation|upregulation of TGFB1 activation|upregulation of TGFbeta 1 activation|upregulation of latent-TGF-beta1 activation|upregulation of transforming growth factor beta1 activation|upregulation of transforming growth factor-beta1 activation http://purl.obolibrary.org/obo/GO_1901394 GO:0036530 biolink:BiologicalProcess protein deglycation, methylglyoxal removal The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein. go.json protein deglycation of methylglyoxal-glycated protein http://purl.obolibrary.org/obo/GO_0036530 gocheck_do_not_annotate GO:0036531 biolink:BiologicalProcess glutathione deglycation The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine. go.json http://purl.obolibrary.org/obo/GO_0036531 GO:1901395 biolink:BiologicalProcess regulation of transforming growth factor beta2 activation Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation. go.json regulation of TGF-beta 2 activation|regulation of TGFB2 activation|regulation of TGFbeta 2 activation http://purl.obolibrary.org/obo/GO_1901395 GO:1901392 biolink:BiologicalProcess regulation of transforming growth factor beta1 activation Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation. go.json regulation of L-TGF-beta 1 activation|regulation of TGF-beta 1 activation|regulation of TGFB1 activation|regulation of TGFbeta 1 activation|regulation of latent-TGF-beta1 activation|regulation of transforming growth factor-beta1 activation http://purl.obolibrary.org/obo/GO_1901392 GO:1901393 biolink:BiologicalProcess negative regulation of transforming growth factor beta1 activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation. go.json down regulation of L-TGF-beta 1 activation|down regulation of TGF-beta 1 activation|down regulation of TGFB1 activation|down regulation of TGFbeta 1 activation|down regulation of latent-TGF-beta1 activation|down regulation of transforming growth factor beta1 activation|down regulation of transforming growth factor-beta1 activation|down-regulation of L-TGF-beta 1 activation|down-regulation of TGF-beta 1 activation|down-regulation of TGFB1 activation|down-regulation of TGFbeta 1 activation|down-regulation of latent-TGF-beta1 activation|down-regulation of transforming growth factor beta1 activation|down-regulation of transforming growth factor-beta1 activation|downregulation of L-TGF-beta 1 activation|downregulation of TGF-beta 1 activation|downregulation of TGFB1 activation|downregulation of TGFbeta 1 activation|downregulation of latent-TGF-beta1 activation|downregulation of transforming growth factor beta1 activation|downregulation of transforming growth factor-beta1 activation|inhibition of L-TGF-beta 1 activation|inhibition of TGF-beta 1 activation|inhibition of TGFB1 activation|inhibition of TGFbeta 1 activation|inhibition of latent-TGF-beta1 activation|inhibition of transforming growth factor beta1 activation|inhibition of transforming growth factor-beta1 activation|negative regulation of L-TGF-beta 1 activation|negative regulation of TGF-beta 1 activation|negative regulation of TGFB1 activation|negative regulation of TGFbeta 1 activation|negative regulation of latent-TGF-beta1 activation|negative regulation of transforming growth factor-beta1 activation http://purl.obolibrary.org/obo/GO_1901393 GO:1901390 biolink:BiologicalProcess positive regulation of transforming growth factor beta activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation. go.json activation of L-TGF-beta activation|activation of TGF-B activation|activation of TGF-beta activation|activation of TGFB activation|activation of TGFbeta activation|activation of latent TGF-beta activation|activation of transforming growth factor beta activation|positive regulation of L-TGF-beta activation|positive regulation of TGF-B activation|positive regulation of TGF-beta activation|positive regulation of TGFB activation|positive regulation of TGFbeta activation|positive regulation of latent TGF-beta activation|up regulation of L-TGF-beta activation|up regulation of TGF-B activation|up regulation of TGF-beta activation|up regulation of TGFB activation|up regulation of TGFbeta activation|up regulation of latent TGF-beta activation|up regulation of transforming growth factor beta activation|up-regulation of L-TGF-beta activation|up-regulation of TGF-B activation|up-regulation of TGF-beta activation|up-regulation of TGFB activation|up-regulation of TGFbeta activation|up-regulation of latent TGF-beta activation|up-regulation of transforming growth factor beta activation|upregulation of L-TGF-beta activation|upregulation of TGF-B activation|upregulation of TGF-beta activation|upregulation of TGFB activation|upregulation of TGFbeta activation|upregulation of latent TGF-beta activation|upregulation of transforming growth factor beta activation http://purl.obolibrary.org/obo/GO_1901390 GO:0036527 biolink:BiologicalProcess peptidyl-arginine deglycation The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein. go.json deglycation of N-acetylarginine http://purl.obolibrary.org/obo/GO_0036527 gocheck_do_not_annotate GO:0036528 biolink:BiologicalProcess peptidyl-lysine deglycation The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. go.json deglycation of N-acetyllysine http://purl.obolibrary.org/obo/GO_0036528 gocheck_do_not_annotate GO:0036529 biolink:BiologicalProcess protein deglycation, glyoxal removal The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein. go.json protein deglycation of glyoxal-glycated protein http://purl.obolibrary.org/obo/GO_0036529 gocheck_do_not_annotate GO:1901398 biolink:BiologicalProcess regulation of transforming growth factor beta3 activation Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation. go.json regulation of TGF-beta 3 activation|regulation of TGFB3 activation|regulation of TGFbeta 3 activation http://purl.obolibrary.org/obo/GO_1901398 GO:1901399 biolink:BiologicalProcess negative regulation of transforming growth factor beta3 activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation. go.json down regulation of TGF-beta 3 activation|down regulation of TGFB3 activation|down regulation of TGFbeta 3 activation|down regulation of transforming growth factor beta3 activation|down-regulation of TGF-beta 3 activation|down-regulation of TGFB3 activation|down-regulation of TGFbeta 3 activation|down-regulation of transforming growth factor beta3 activation|downregulation of TGF-beta 3 activation|downregulation of TGFB3 activation|downregulation of TGFbeta 3 activation|downregulation of transforming growth factor beta3 activation|inhibition of TGF-beta 3 activation|inhibition of TGFB3 activation|inhibition of TGFbeta 3 activation|inhibition of transforming growth factor beta3 activation|negative regulation of TGF-beta 3 activation|negative regulation of TGFB3 activation|negative regulation of TGFbeta 3 activation http://purl.obolibrary.org/obo/GO_1901399 GO:1901396 biolink:BiologicalProcess negative regulation of transforming growth factor beta2 activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation. go.json down regulation of TGF-beta 2 activation|down regulation of TGFB2 activation|down regulation of TGFbeta 2 activation|down regulation of transforming growth factor beta2 activation|down-regulation of TGF-beta 2 activation|down-regulation of TGFB2 activation|down-regulation of TGFbeta 2 activation|down-regulation of transforming growth factor beta2 activation|downregulation of TGF-beta 2 activation|downregulation of TGFB2 activation|downregulation of TGFbeta 2 activation|downregulation of transforming growth factor beta2 activation|inhibition of TGF-beta 2 activation|inhibition of TGFB2 activation|inhibition of TGFbeta 2 activation|inhibition of transforming growth factor beta2 activation|negative regulation of TGF-beta 2 activation|negative regulation of TGFB2 activation|negative regulation of TGFbeta 2 activation http://purl.obolibrary.org/obo/GO_1901396 GO:1901397 biolink:BiologicalProcess positive regulation of transforming growth factor beta2 activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation. go.json activation of TGF-beta 2 activation|activation of TGFB2 activation|activation of TGFbeta 2 activation|activation of transforming growth factor beta2 activation|positive regulation of TGF-beta 2 activation|positive regulation of TGFB2 activation|positive regulation of TGFbeta 2 activation|up regulation of TGF-beta 2 activation|up regulation of TGFB2 activation|up regulation of TGFbeta 2 activation|up regulation of transforming growth factor beta2 activation|up-regulation of TGF-beta 2 activation|up-regulation of TGFB2 activation|up-regulation of TGFbeta 2 activation|up-regulation of transforming growth factor beta2 activation|upregulation of TGF-beta 2 activation|upregulation of TGFB2 activation|upregulation of TGFbeta 2 activation|upregulation of transforming growth factor beta2 activation http://purl.obolibrary.org/obo/GO_1901397 GO:0036520 biolink:BiologicalProcess astrocyte-dopaminergic neuron signaling Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron. go.json astrocyte-dopaminergic neuron cell signaling|dopaminergic neuron-astrocyte crosstalk|mesencephalic dopaminergic neuron-astrocyte crosstalk|midbrain dopaminergic neuron-astrocyte crosstalk http://purl.obolibrary.org/obo/GO_0036520 GO:0036521 biolink:BiologicalProcess modulation by symbiont of host protein localization to phagocytic vesicle Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host protein localisation to phagosome http://purl.obolibrary.org/obo/GO_0036521 GO:0036522 biolink:BiologicalProcess negative regulation by symbiont of host protein localization to phagocytic vesicle Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host protein localisation to phagosome|inhibition of host protein localisation to phagosome|suppression of host protein localisation to phagosome http://purl.obolibrary.org/obo/GO_0036522 GO:0036523 biolink:BiologicalProcess obsolete induction by symbiont of host cytokine production OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json 'induction by symbiont of host cytokine secretion'|induction by symbiont of host cytokine secretion|positive regulation by symbiont of host cytokine secretion True http://purl.obolibrary.org/obo/GO_0036523 GO:0036524 biolink:MolecularActivity protein deglycase activity Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. EC:3.5.1.124|MetaCyc:RXN-17630|MetaCyc:RXN-17632|MetaCyc:RXN-17634 go.json glyoxylase III|protein deglycating enzyme http://purl.obolibrary.org/obo/GO_0036524 GO:0036525 biolink:BiologicalProcess protein deglycation The removal of a sugar or dicarbonyl from a glycated protein. go.json glycated protein repair http://purl.obolibrary.org/obo/GO_0036525 gocheck_do_not_annotate GO:0036526 biolink:BiologicalProcess peptidyl-cysteine deglycation The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein. go.json deglycation of N-acetylcysteine http://purl.obolibrary.org/obo/GO_0036526 gocheck_do_not_annotate GO:0061500 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061500 GO:0061501 biolink:MolecularActivity 2',3'-cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP). EC:2.7.7.86|RHEA:42064|Reactome:R-HSA-3244614 go.json 2',3' cyclic GMP-AMP synthase activity|2',3' cyclic-GMP-AMP synthase activity|cyclic 2',3' GAMP synthase activity|cyclic-GMP-AMP synthase activity http://purl.obolibrary.org/obo/GO_0061501 GO:0061502 biolink:BiologicalProcess early endosome to recycling endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes. go.json http://purl.obolibrary.org/obo/GO_0061502 GO:0061503 biolink:MolecularActivity tRNA threonylcarbamoyladenosine dehydratase Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. go.json http://purl.obolibrary.org/obo/GO_0061503 GO:0061504 biolink:BiologicalProcess cyclic threonylcarbamoyladenosine biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. go.json http://purl.obolibrary.org/obo/GO_0061504 GO:0061505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061505 GO:0061506 biolink:MolecularActivity obsolete DNA topoisomerase type II (ATP-independent) activity OBSOLETE. Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. go.json True http://purl.obolibrary.org/obo/GO_0061506 GO:0061507 biolink:MolecularActivity 2',3'-cyclic GMP-AMP binding Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages. go.json 2',3' cGAMP binding|2',3' cyclic GAMP binding|2',3'-cGAMP binding|2',3'-cyclic GAMP binding|2',5-3',5'-cyclic GMP-AMP binding|c[G(2',5')pA(3',5')p] binding|cyclic-GMP-AMP binding http://purl.obolibrary.org/obo/GO_0061507 GO:0061508 biolink:BiologicalProcess obsolete CDP phosphorylation OBSOLETE. The process of introducing a phosphate group into CDP to produce a CTP. go.json True http://purl.obolibrary.org/obo/GO_0061508 GO:0061509 biolink:BiologicalProcess asymmetric protein localization to old mitotic spindle pole body Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically. go.json http://purl.obolibrary.org/obo/GO_0061509 GO:0061520 biolink:BiologicalProcess Langerhans cell differentiation The process in which a precursor cell type acquires the specialized features of a Langerhans cell. go.json http://purl.obolibrary.org/obo/GO_0061520 GO:0061521 biolink:BiologicalProcess hepatic stellate cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell. go.json http://purl.obolibrary.org/obo/GO_0061521 GO:0061522 biolink:MolecularActivity 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA. go.json http://purl.obolibrary.org/obo/GO_0061522 GO:0061523 biolink:BiologicalProcess cilium disassembly A cellular process that results in the breakdown of a cilium. go.json cilium resorption http://purl.obolibrary.org/obo/GO_0061523 GO:0061524 biolink:BiologicalProcess central canal development The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0061524 GO:0061525 biolink:BiologicalProcess hindgut development The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. go.json http://purl.obolibrary.org/obo/GO_0061525 GO:0061526 biolink:BiologicalProcess acetylcholine secretion The regulated release of acetylcholine by a cell. go.json http://purl.obolibrary.org/obo/GO_0061526 GO:0061527 biolink:BiologicalProcess dopamine secretion, neurotransmission The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061527 GO:0061528 biolink:BiologicalProcess aspartate secretion The regulated release of aspartate by a cell. go.json http://purl.obolibrary.org/obo/GO_0061528 GO:0061529 biolink:BiologicalProcess epinephrine secretion, neurotransmission The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter. go.json adrenaline secretion, neurotransmission http://purl.obolibrary.org/obo/GO_0061529 GO:0061510 biolink:BiologicalProcess asymmetric protein localization to new mitotic spindle pole body Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically. go.json http://purl.obolibrary.org/obo/GO_0061510 GO:0061511 biolink:BiologicalProcess centriole elongation The centrosome organization process by which a centriole increases in length as part of the process of replication. go.json http://purl.obolibrary.org/obo/GO_0061511 GO:0061512 biolink:BiologicalProcess protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium. go.json http://purl.obolibrary.org/obo/GO_0061512 GO:0061513 biolink:MolecularActivity glucose 6-phosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out). Reactome:R-HSA-198513|Reactome:R-HSA-3229118|Reactome:R-HSA-3257122 go.json glucose 6-phosphate:phosphate antiporter activity http://purl.obolibrary.org/obo/GO_0061513 GO:0061514 biolink:BiologicalProcess interleukin-34-mediated signaling pathway The series of molecular signals initiated by interleukin-34 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json http://purl.obolibrary.org/obo/GO_0061514 GO:0061515 biolink:BiologicalProcess myeloid cell development The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061515 GO:0061516 biolink:BiologicalProcess monocyte proliferation The expansion of a monocyte population by cell division. go.json http://purl.obolibrary.org/obo/GO_0061516 GO:0061517 biolink:BiologicalProcess macrophage proliferation The expansion of a macrophage population by cell division. go.json http://purl.obolibrary.org/obo/GO_0061517 GO:0061518 biolink:BiologicalProcess microglial cell proliferation The expansion of a microglial cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0061518 GO:0061519 biolink:BiologicalProcess macrophage homeostasis The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0061519 GO:1901309 biolink:BiologicalProcess obsolete negative regulation of sterol regulatory element binding protein cleavage OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage. go.json down regulation of SREBP cleavage|down regulation of sterol regulatory element binding protein cleavage|down-regulation of SREBP cleavage|down-regulation of sterol regulatory element binding protein cleavage|downregulation of SREBP cleavage|downregulation of sterol regulatory element binding protein cleavage|inhibition of SREBP cleavage|inhibition of SREBP processing|inhibition of sterol regulatory element binding protein cleavage|negative regulation of SREBP cleavage True http://purl.obolibrary.org/obo/GO_1901309 GO:1901307 biolink:BiologicalProcess positive regulation of spermidine biosynthetic process Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process. go.json activation of spermidine anabolism|activation of spermidine biosynthesis|activation of spermidine biosynthetic process|activation of spermidine formation|activation of spermidine synthesis|positive regulation of spermidine anabolism|positive regulation of spermidine biosynthesis|positive regulation of spermidine formation|positive regulation of spermidine synthesis|up regulation of spermidine anabolism|up regulation of spermidine biosynthesis|up regulation of spermidine biosynthetic process|up regulation of spermidine formation|up regulation of spermidine synthesis|up-regulation of spermidine anabolism|up-regulation of spermidine biosynthesis|up-regulation of spermidine biosynthetic process|up-regulation of spermidine formation|up-regulation of spermidine synthesis|upregulation of spermidine anabolism|upregulation of spermidine biosynthesis|upregulation of spermidine biosynthetic process|upregulation of spermidine formation|upregulation of spermidine synthesis http://purl.obolibrary.org/obo/GO_1901307 GO:1901308 biolink:BiologicalProcess obsolete regulation of sterol regulatory element binding protein cleavage OBSOLETE. Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage. go.json regulation of SREBP cleavage True http://purl.obolibrary.org/obo/GO_1901308 GO:1901305 biolink:BiologicalProcess negative regulation of spermidine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of spermidine biosynthetic process. go.json down regulation of spermidine anabolism|down regulation of spermidine biosynthesis|down regulation of spermidine biosynthetic process|down regulation of spermidine formation|down regulation of spermidine synthesis|down-regulation of spermidine anabolism|down-regulation of spermidine biosynthesis|down-regulation of spermidine biosynthetic process|down-regulation of spermidine formation|down-regulation of spermidine synthesis|downregulation of spermidine anabolism|downregulation of spermidine biosynthesis|downregulation of spermidine biosynthetic process|downregulation of spermidine formation|downregulation of spermidine synthesis|inhibition of spermidine anabolism|inhibition of spermidine biosynthesis|inhibition of spermidine biosynthetic process|inhibition of spermidine formation|inhibition of spermidine synthesis|negative regulation of spermidine anabolism|negative regulation of spermidine biosynthesis|negative regulation of spermidine formation|negative regulation of spermidine synthesis http://purl.obolibrary.org/obo/GO_1901305 GO:1901303 biolink:BiologicalProcess negative regulation of cargo loading into COPII-coated vesicle Any process that stops, prevents or reduces the frequency, rate or extent of cargo loading into a COPII-coated vesicle. go.json down regulation of COPII coat-cargo complex assembly|down regulation of cargo loading into COPII vesicle|down regulation of cargo loading into COPII-coated vesicle|down regulation of cargo selection into COPII-coated vesicle|down-regulation of COPII coat-cargo complex assembly|down-regulation of cargo loading into COPII vesicle|down-regulation of cargo loading into COPII-coated vesicle|down-regulation of cargo selection into COPII-coated vesicle|downregulation of COPII coat-cargo complex assembly|downregulation of cargo loading into COPII vesicle|downregulation of cargo loading into COPII-coated vesicle|downregulation of cargo selection into COPII-coated vesicle|inhibition of COPII coat-cargo complex assembly|inhibition of COPII vesicle protein binding|inhibition of cargo loading into COPII vesicle|inhibition of cargo loading into COPII-coated vesicle|inhibition of cargo selection into COPII-coated vesicle|inhibition of protein sorting into COPII-coated vesicles|negative regulation of COPII coat-cargo complex assembly|negative regulation of cargo loading into COPII vesicle|negative regulation of cargo selection into COPII-coated vesicle http://purl.obolibrary.org/obo/GO_1901303 GO:1901304 biolink:BiologicalProcess regulation of spermidine biosynthetic process Any process that modulates the frequency, rate or extent of spermidine biosynthetic process. go.json regulation of spermidine anabolism|regulation of spermidine biosynthesis|regulation of spermidine formation|regulation of spermidine synthesis http://purl.obolibrary.org/obo/GO_1901304 GO:1901301 biolink:BiologicalProcess regulation of cargo loading into COPII-coated vesicle Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle. go.json regulation of COPII coat-cargo complex assembly|regulation of cargo loading into COPII vesicle|regulation of cargo selection into COPII-coated vesicle http://purl.obolibrary.org/obo/GO_1901301 GO:1901300 biolink:BiologicalProcess positive regulation of hydrogen peroxide-mediated programmed cell death Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. go.json activation of hydrogen peroxide-mediated programmed cell death|up regulation of hydrogen peroxide-mediated programmed cell death|up-regulation of hydrogen peroxide-mediated programmed cell death|upregulation of hydrogen peroxide-mediated programmed cell death http://purl.obolibrary.org/obo/GO_1901300 GO:0061540 biolink:BiologicalProcess octopamine secretion, neurotransmission The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061540 GO:0061541 biolink:BiologicalProcess rhabdomere morphogenesis The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. go.json http://purl.obolibrary.org/obo/GO_0061541 GO:0061542 biolink:MolecularActivity 3-demethylubiquinol-n 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. EC:2.1.1.64|RHEA:44380 go.json 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase|5-demethylubiquinone-10 methyltransferase|5-demethylubiquinone-9 methyltransferase|OMHMB-methyltransferase|S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase http://purl.obolibrary.org/obo/GO_0061542 GO:0061543 biolink:MolecularActivity 3-demethylubiquinol-6 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6. go.json http://purl.obolibrary.org/obo/GO_0061543 GO:0061544 biolink:BiologicalProcess peptide secretion, neurotransmission The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061544 GO:0061545 biolink:BiologicalProcess tyramine secretion The regulated release of a tyramine by a cell. go.json http://purl.obolibrary.org/obo/GO_0061545 GO:0061546 biolink:BiologicalProcess tyramine secretion, neurotransmission The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061546 GO:0061547 biolink:MolecularActivity glycogen synthase activity, transferring glucose-1-phosphate Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. Reactome:R-HSA-3780994|Reactome:R-HSA-3781024 go.json http://purl.obolibrary.org/obo/GO_0061547 GO:0061548 biolink:BiologicalProcess ganglion development The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. go.json ganglia development|gangliogenesis http://purl.obolibrary.org/obo/GO_0061548 GO:0061549 biolink:BiologicalProcess sympathetic ganglion development The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. go.json sympathetic ganglia development http://purl.obolibrary.org/obo/GO_0061549 GO:1901318 biolink:BiologicalProcess negative regulation of flagellated sperm motility Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility. go.json down regulation of sperm motility|down regulation of sperm movement|down-regulation of sperm motility|down-regulation of sperm movement|downregulation of sperm motility|downregulation of sperm movement|inhibition of sperm motility|inhibition of sperm movement|negative regulation of sperm motility|negative regulation of sperm movement http://purl.obolibrary.org/obo/GO_1901318 GO:1901319 biolink:BiologicalProcess positive regulation of trehalose catabolic process Any process that activates or increases the frequency, rate or extent of trehalose catabolic process. go.json activation of mycose catabolic process|activation of mycose catabolism|activation of mykose catabolic process|activation of mykose catabolism|activation of trehalose breakdown|activation of trehalose catabolic process|activation of trehalose catabolism|activation of trehalose degradation|positive regulation of mycose catabolic process|positive regulation of mycose catabolism|positive regulation of mykose catabolic process|positive regulation of mykose catabolism|positive regulation of trehalose breakdown|positive regulation of trehalose catabolism|positive regulation of trehalose degradation|up regulation of mycose catabolic process|up regulation of mycose catabolism|up regulation of mykose catabolic process|up regulation of mykose catabolism|up regulation of trehalose breakdown|up regulation of trehalose catabolic process|up regulation of trehalose catabolism|up regulation of trehalose degradation|up-regulation of mycose catabolic process|up-regulation of mycose catabolism|up-regulation of mykose catabolic process|up-regulation of mykose catabolism|up-regulation of trehalose breakdown|up-regulation of trehalose catabolic process|up-regulation of trehalose catabolism|up-regulation of trehalose degradation|upregulation of mycose catabolic process|upregulation of mycose catabolism|upregulation of mykose catabolic process|upregulation of mykose catabolism|upregulation of trehalose breakdown|upregulation of trehalose catabolic process|upregulation of trehalose catabolism|upregulation of trehalose degradation http://purl.obolibrary.org/obo/GO_1901319 GO:1901316 biolink:BiologicalProcess positive regulation of histone H2A K63-linked ubiquitination Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination. go.json activation of histone H2A K63-linked ubiquitination|up regulation of histone H2A K63-linked ubiquitination|up-regulation of histone H2A K63-linked ubiquitination|upregulation of histone H2A K63-linked ubiquitination http://purl.obolibrary.org/obo/GO_1901316 GO:1901317 biolink:BiologicalProcess regulation of flagellated sperm motility Any process that modulates the frequency, rate or extent of flagellated sperm motility. go.json regulation of sperm motility|regulation of sperm movement http://purl.obolibrary.org/obo/GO_1901317 GO:1901314 biolink:BiologicalProcess regulation of histone H2A K63-linked ubiquitination Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination. go.json http://purl.obolibrary.org/obo/GO_1901314 GO:1901315 biolink:BiologicalProcess negative regulation of histone H2A K63-linked ubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination. go.json down regulation of histone H2A K63-linked ubiquitination|down-regulation of histone H2A K63-linked ubiquitination|downregulation of histone H2A K63-linked ubiquitination|inhibition of histone H2A K63-linked ubiquitination http://purl.obolibrary.org/obo/GO_1901315 GO:1901312 biolink:BiologicalProcess obsolete negative regulation of gene expression involved in extracellular matrix organization OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of gene expression involved in extracellular matrix organization. go.json down regulation of expression of extracellular matrix proteins|down regulation of extracellular matrix protein production|down regulation of gene expression involved in extracellular matrix organization|down-regulation of expression of extracellular matrix proteins|down-regulation of extracellular matrix protein production|down-regulation of gene expression involved in extracellular matrix organization|downregulation of expression of extracellular matrix proteins|downregulation of extracellular matrix protein production|downregulation of gene expression involved in extracellular matrix organization|inhibition of expression of extracellular matrix proteins|inhibition of extracellular matrix protein production|inhibition of gene expression involved in extracellular matrix organization|negative regulation of expression of extracellular matrix proteins|negative regulation of extracellular matrix protein production True http://purl.obolibrary.org/obo/GO_1901312 GO:1901313 biolink:BiologicalProcess obsolete positive regulation of gene expression involved in extracellular matrix organization OBSOLETE. Any process that activates or increases the frequency, rate or extent of gene expression involved in extracellular matrix organization. go.json activation of expression of extracellular matrix proteins|activation of extracellular matrix protein production|activation of gene expression involved in extracellular matrix organization|positive regulation of expression of extracellular matrix proteins|positive regulation of extracellular matrix protein production|up regulation of expression of extracellular matrix proteins|up regulation of extracellular matrix protein production|up regulation of gene expression involved in extracellular matrix organization|up-regulation of expression of extracellular matrix proteins|up-regulation of extracellular matrix protein production|up-regulation of gene expression involved in extracellular matrix organization|upregulation of expression of extracellular matrix proteins|upregulation of extracellular matrix protein production|upregulation of gene expression involved in extracellular matrix organization True http://purl.obolibrary.org/obo/GO_1901313 GO:1901310 biolink:BiologicalProcess obsolete positive regulation of sterol regulatory element binding protein cleavage OBSOLETE. Any process that activates or increases the frequency, rate or extent of sterol regulatory element binding protein cleavage. go.json activation of SREBP cleavage|activation of sterol regulatory element binding protein cleavage|positive regulation of SREBP cleavage|up regulation of SREBP cleavage|up regulation of sterol regulatory element binding protein cleavage|up-regulation of SREBP cleavage|up-regulation of sterol regulatory element binding protein cleavage|upregulation of SREBP cleavage|upregulation of sterol regulatory element binding protein cleavage True http://purl.obolibrary.org/obo/GO_1901310 GO:1901311 biolink:BiologicalProcess obsolete regulation of gene expression involved in extracellular matrix organization OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression involved in extracellular matrix organization. go.json regulation of expression of extracellular matrix proteins|regulation of extracellular matrix protein production True http://purl.obolibrary.org/obo/GO_1901311 GO:0061530 biolink:BiologicalProcess aspartate secretion, neurotransmission The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061530 GO:0061531 biolink:BiologicalProcess primary amine secretion The regulated release of a primary amine by a cell. go.json http://purl.obolibrary.org/obo/GO_0061531 GO:0061532 biolink:BiologicalProcess primary amine secretion, neurotransmission The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061532 GO:0061533 biolink:BiologicalProcess norepinephrine secretion, neurotransmission The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter. go.json noradrenaline secretion, neurotransmission http://purl.obolibrary.org/obo/GO_0061533 GO:0061534 biolink:BiologicalProcess gamma-aminobutyric acid secretion, neurotransmission The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061534 GO:0061535 biolink:BiologicalProcess glutamate secretion, neurotransmission The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061535 GO:0061536 biolink:BiologicalProcess glycine secretion The controlled release of glycine by a cell. go.json http://purl.obolibrary.org/obo/GO_0061536 GO:0061537 biolink:BiologicalProcess glycine secretion, neurotransmission The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061537 GO:0061538 biolink:BiologicalProcess histamine secretion, neurotransmission The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061538 GO:0061539 biolink:BiologicalProcess octopamine secretion The controlled release of octopamine by a cell. go.json http://purl.obolibrary.org/obo/GO_0061539 GO:0061700 biolink:CellularComponent GATOR2 complex A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. go.json SEACAT complex http://purl.obolibrary.org/obo/GO_0061700 GO:0061701 biolink:CellularComponent bacterial outer membrane vesicle A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes. go.json http://purl.obolibrary.org/obo/GO_0061701 GO:0061702 biolink:CellularComponent canonical inflammasome complex A cytosolic protein complex that is capable of activating caspase-1. go.json http://purl.obolibrary.org/obo/GO_0061702 GO:0061703 biolink:CellularComponent pyroptosome complex A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis. go.json ASC pyroptosome http://purl.obolibrary.org/obo/GO_0061703 GO:0061704 biolink:BiologicalProcess glycolytic process from sucrose The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. go.json http://purl.obolibrary.org/obo/GO_0061704 GO:0061705 biolink:BiologicalProcess sucrose catabolic process to fructose-6-phosphate through glucose and fructose The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates. MetaCyc:PWY-621 go.json http://purl.obolibrary.org/obo/GO_0061705 GO:0061706 biolink:BiologicalProcess glycolytic process from sucrose through glucose and fructose The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. MetaCyc:PWY-1042 go.json http://purl.obolibrary.org/obo/GO_0061706 GO:0061707 biolink:BiologicalProcess extracellular exosome macropinocytosis The single-organism macropinocytosis process that results in the uptake of an extracellular exosome. go.json http://purl.obolibrary.org/obo/GO_0061707 GO:0061708 biolink:MolecularActivity tRNA-5-taurinomethyluridine 2-sulfurtransferase Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. EC:2.8.1.14|MetaCyc:RXN-16821|RHEA:47040|Reactome:R-HSA-6787447 go.json http://purl.obolibrary.org/obo/GO_0061708 GO:0061709 biolink:BiologicalProcess reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. go.json ER autophagy|ER degradation|ER-phagy|autophagy of the ER|autophagy of the endoplasmic reticulum|endoplasmic reticulum autophagy|endoplasmic reticulum degradation http://purl.obolibrary.org/obo/GO_0061709 GO:0071087 biolink:CellularComponent alpha11-beta1 integrin-collagen type I complex A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen. go.json ITGA11-ITGB1-COL1A1 complex http://purl.obolibrary.org/obo/GO_0071087 GO:0071088 biolink:CellularComponent alpha5-beta1 integrin-tissue transglutaminase complex A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase. go.json ITGA5-ITGB1-TGM2 complex http://purl.obolibrary.org/obo/GO_0071088 GO:0071085 biolink:CellularComponent alphaIIb-beta3 integrin-CD9 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9. go.json ITGA2b-ITGB3-CD9 complex http://purl.obolibrary.org/obo/GO_0071085 GO:0071086 biolink:CellularComponent alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib. go.json ITGA2b-ITGB3-CD9-GP1b-CD47 complex http://purl.obolibrary.org/obo/GO_0071086 GO:0071083 biolink:CellularComponent alphaV-beta3 integrin-CD47-FCER2 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2). go.json ITGAV-ITGB3-CD447-FCER2 complex http://purl.obolibrary.org/obo/GO_0071083 GO:0071084 biolink:CellularComponent alpha2-beta1 integrin-CD47 complex A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47. go.json ITGA2-ITGB1-CD47 complex http://purl.obolibrary.org/obo/GO_0071084 GO:0071081 biolink:CellularComponent alpha3-beta1 integrin-CD63 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63. go.json ITGA3-ITGB1-CD63 complex http://purl.obolibrary.org/obo/GO_0071081 GO:0071082 biolink:CellularComponent alpha9-beta1 integrin-tenascin complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin. go.json ITGA9-ITGB1-TNC complex http://purl.obolibrary.org/obo/GO_0071082 GO:0071080 biolink:CellularComponent alpha3-beta1 integrin-basigin complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin. go.json ITGA3-ITGB1-BSG complex http://purl.obolibrary.org/obo/GO_0071080 GO:1901288 biolink:BiologicalProcess iron-sulfur-molybdenum cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor. go.json FeMo-co anabolism|FeMo-co biosynthesis|FeMo-co biosynthetic process|FeMo-co formation|FeMo-co synthesis|iron-molybdenum cofactor anabolism|iron-molybdenum cofactor biosynthesis|iron-molybdenum cofactor biosynthetic process|iron-molybdenum cofactor formation|iron-molybdenum cofactor synthesis|iron-sulfur-molybdenum cofactor anabolism|iron-sulfur-molybdenum cofactor biosynthesis|iron-sulfur-molybdenum cofactor formation|iron-sulfur-molybdenum cofactor synthesis http://purl.obolibrary.org/obo/GO_1901288 GO:1901289 biolink:BiologicalProcess succinyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of succinyl-CoA. go.json succinyl-CoA breakdown|succinyl-CoA catabolism|succinyl-CoA degradation http://purl.obolibrary.org/obo/GO_1901289 GO:1901286 biolink:BiologicalProcess iron-sulfur-molybdenum cofactor metabolic process The chemical reactions and pathways involving iron-sulfur-molybdenum cofactor. go.json FeMo-co metabolic process|FeMo-co metabolism|iron-molybdenum cofactor metabolic process|iron-molybdenum cofactor metabolism|iron-sulfur-molybdenum cofactor metabolism http://purl.obolibrary.org/obo/GO_1901286 GO:1901287 biolink:BiologicalProcess iron-sulfur-molybdenum cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor. go.json FeMo-co breakdown|FeMo-co catabolic process|FeMo-co catabolism|FeMo-co degradation|iron-molybdenum breakdown|iron-molybdenum catabolic process|iron-molybdenum catabolism|iron-molybdenum degradation|iron-sulfur-molybdenum cofactor breakdown|iron-sulfur-molybdenum cofactor catabolism|iron-sulfur-molybdenum cofactor degradation http://purl.obolibrary.org/obo/GO_1901287 GO:1901295 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment. go.json regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment http://purl.obolibrary.org/obo/GO_1901295 GO:1901296 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment. go.json down regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|down regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|down-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|down-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|downregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|downregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|inhibition of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|inhibition of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|negative regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|negative regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment http://purl.obolibrary.org/obo/GO_1901296 GO:1901293 biolink:BiologicalProcess nucleoside phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. go.json nucleoside phosphate anabolism|nucleoside phosphate biosynthesis|nucleoside phosphate formation|nucleoside phosphate synthesis http://purl.obolibrary.org/obo/GO_1901293 GO:1901294 biolink:BiologicalProcess obsolete negative regulation of SREBP signaling pathway by negative regulation of DNA binding OBSOLETE. Negative regulation of DNA binding that results in negative regulation of a SREBP signaling pathway. go.json inhibition of SREBP-dependent transcription by blocking DNA binding|negative regulation of SREBP signaling pathway by down regulation of DNA binding|negative regulation of SREBP signaling pathway by down-regulation of DNA binding|negative regulation of SREBP signaling pathway by downregulation of DNA binding|negative regulation of SREBP signaling pathway by inhibition of DNA binding|negative regulation of SREBP-mediated signaling pathway by down regulation of DNA binding|negative regulation of SREBP-mediated signaling pathway by down-regulation of DNA binding|negative regulation of SREBP-mediated signaling pathway by downregulation of DNA binding|negative regulation of SREBP-mediated signaling pathway by inhibition of DNA binding|negative regulation of SREBP-mediated signaling pathway by negative regulation of DNA binding|negative regulation of SREBP-mediated signalling pathway by down regulation of DNA binding|negative regulation of SREBP-mediated signalling pathway by down-regulation of DNA binding|negative regulation of SREBP-mediated signalling pathway by downregulation of DNA binding|negative regulation of SREBP-mediated signalling pathway by inhibition of DNA binding|negative regulation of SREBP-mediated signalling pathway by negative regulation of DNA binding True http://purl.obolibrary.org/obo/GO_1901294 GO:1901291 biolink:BiologicalProcess negative regulation of double-strand break repair via single-strand annealing Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing. go.json down regulation of double-strand break repair via single-strand annealing|down-regulation of double-strand break repair via single-strand annealing|downregulation of double-strand break repair via single-strand annealing|inhibition of double-strand break repair via single-strand annealing http://purl.obolibrary.org/obo/GO_1901291 GO:1901292 biolink:BiologicalProcess nucleoside phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. go.json nucleoside phosphate breakdown|nucleoside phosphate catabolism|nucleoside phosphate degradation http://purl.obolibrary.org/obo/GO_1901292 GO:1901290 biolink:BiologicalProcess succinyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of succinyl-CoA. go.json succinyl-CoA anabolism|succinyl-CoA biosynthesis|succinyl-CoA formation|succinyl-CoA synthesis http://purl.obolibrary.org/obo/GO_1901290 GO:0071089 biolink:CellularComponent alphaV-beta3 integrin-tissue transglutaminase complex A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase. go.json ITGAV-ITGB3-TGM2 complex http://purl.obolibrary.org/obo/GO_0071089 GO:0071076 biolink:BiologicalProcess RNA 3' uridylation The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0071076 GO:0071077 biolink:MolecularActivity adenosine 3',5'-bisphosphate transmembrane transporter activity Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other. go.json adenosine 3',5'-diphosphate transporter activity|adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0071077 GO:0071074 biolink:MolecularActivity eukaryotic initiation factor eIF2 binding Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. go.json http://purl.obolibrary.org/obo/GO_0071074 GO:0071075 biolink:CellularComponent CUGBP1-eIF2 complex A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation. go.json http://purl.obolibrary.org/obo/GO_0071075 GO:0071072 biolink:BiologicalProcess negative regulation of phospholipid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. go.json down regulation of phospholipid biosynthetic process|down-regulation of phospholipid biosynthetic process|downregulation of phospholipid biosynthetic process|inhibition of phospholipid biosynthetic process|negative regulation of phospholipid anabolism|negative regulation of phospholipid biosynthesis|negative regulation of phospholipid formation|negative regulation of phospholipid synthesis http://purl.obolibrary.org/obo/GO_0071072 GO:0071073 biolink:BiologicalProcess positive regulation of phospholipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. go.json activation of phospholipid biosynthetic process|positive regulation of phospholipid anabolism|positive regulation of phospholipid biosynthesis|positive regulation of phospholipid formation|positive regulation of phospholipid synthesis|stimulation of phospholipid biosynthetic process|up regulation of phospholipid biosynthetic process|up-regulation of phospholipid biosynthetic process|upregulation of phospholipid biosynthetic process http://purl.obolibrary.org/obo/GO_0071073 GO:0071070 biolink:CellularComponent alpha4-beta1 integrin-thrombospondin-2 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2. go.json ITGA4-ITGB1-THBS2 complex http://purl.obolibrary.org/obo/GO_0071070 GO:0071071 biolink:BiologicalProcess regulation of phospholipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. go.json regulation of phospholipid anabolism|regulation of phospholipid biosynthesis|regulation of phospholipid formation|regulation of phospholipid synthesis http://purl.obolibrary.org/obo/GO_0071071 GO:1901299 biolink:BiologicalProcess negative regulation of hydrogen peroxide-mediated programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. go.json down regulation of hydrogen peroxide-mediated programmed cell death|down-regulation of hydrogen peroxide-mediated programmed cell death|downregulation of hydrogen peroxide-mediated programmed cell death|inhibition of hydrogen peroxide-mediated programmed cell death http://purl.obolibrary.org/obo/GO_1901299 GO:1901297 biolink:BiologicalProcess positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment. go.json activation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|activation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|positive regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|positive regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|positive regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment|up regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|up regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|up-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|up-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment|upregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment|upregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment http://purl.obolibrary.org/obo/GO_1901297 GO:1901298 biolink:BiologicalProcess regulation of hydrogen peroxide-mediated programmed cell death Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. go.json http://purl.obolibrary.org/obo/GO_1901298 GO:0071078 biolink:CellularComponent fibronectin-tissue transglutaminase complex A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion. go.json FN-TGM2 complex http://purl.obolibrary.org/obo/GO_0071078 GO:0071079 biolink:CellularComponent alpha2-beta1 integrin-chondroadherin complex A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin. go.json ITGA2-ITGB1-CHAD complex http://purl.obolibrary.org/obo/GO_0071079 GO:0071098 biolink:CellularComponent alpha6-beta4 integrin-Fyn complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn. go.json ITGA6-ITGB4-FYN complex http://purl.obolibrary.org/obo/GO_0071098 GO:0071099 biolink:CellularComponent alphaV-beta6 integrin-TGFbeta-3 complex A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3). go.json ITGAV-ITGB6-TFGB3 complex http://purl.obolibrary.org/obo/GO_0071099 GO:0071096 biolink:CellularComponent alphaV-beta3 integrin-gelsolin complex A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin. go.json ITGAV-ITGB3-Gsn complex http://purl.obolibrary.org/obo/GO_0071096 GO:0071097 biolink:CellularComponent alphaV-beta3 integrin-paxillin-Pyk2 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2. go.json ITGAV-ITGB3-PXN-PTK2b complex http://purl.obolibrary.org/obo/GO_0071097 GO:0071094 biolink:CellularComponent alpha6-beta4 integrin-CD9 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9. go.json ITGA6-ITGB4-CD9 complex http://purl.obolibrary.org/obo/GO_0071094 GO:0071095 biolink:CellularComponent alpha3-beta1 integrin-thrombospondin complex A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin. go.json ITGA3-ITGB1-THBS1 complex http://purl.obolibrary.org/obo/GO_0071095 GO:0071092 biolink:CellularComponent alpha3-beta1 integrin-tissue transglutaminase complex A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase. go.json ITGA3-ITGB1-TGM2 complex http://purl.obolibrary.org/obo/GO_0071092 GO:0071093 biolink:CellularComponent alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase. go.json ITGA5-ITGB1-FN1-TGM2 complex http://purl.obolibrary.org/obo/GO_0071093 GO:0071090 biolink:CellularComponent alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase. go.json ITGA2b-ITGB3-FN1-TGM2 complex http://purl.obolibrary.org/obo/GO_0071090 GO:0071091 biolink:CellularComponent alpha1-beta1 integrin-tissue transglutaminase complex A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase. go.json ITGA1-ITGB1-TGM2 complex http://purl.obolibrary.org/obo/GO_0071091 GO:0046043 biolink:BiologicalProcess TDP metabolic process The chemical reactions and pathways involving TDP, ribosylthymine diphosphate. go.json TDP metabolism http://purl.obolibrary.org/obo/GO_0046043 GO:0046044 biolink:BiologicalProcess TMP metabolic process The chemical reactions and pathways involving TMP, ribosylthymine monophosphate. go.json TMP metabolism http://purl.obolibrary.org/obo/GO_0046044 GO:0071000 biolink:BiologicalProcess response to magnetism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. go.json response to magnetic stimulus http://purl.obolibrary.org/obo/GO_0071000 GO:0046041 biolink:BiologicalProcess ITP metabolic process The chemical reactions and pathways involving ITP, inosine triphosphate. go.json ITP metabolism http://purl.obolibrary.org/obo/GO_0046041 GO:0046042 biolink:BiologicalProcess ITP biosynthetic process The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate. go.json ITP anabolism|ITP biosynthesis|ITP formation|ITP synthesis http://purl.obolibrary.org/obo/GO_0046042 GO:1901208 biolink:BiologicalProcess negative regulation of heart looping Any process that stops, prevents or reduces the frequency, rate or extent of heart looping. go.json down regulation of cardiac looping|down regulation of heart looping|down-regulation of cardiac looping|down-regulation of heart looping|downregulation of cardiac looping|downregulation of heart looping|inhibition of cardiac looping|inhibition of heart looping|negative regulation of cardiac looping http://purl.obolibrary.org/obo/GO_1901208 GO:1901209 biolink:BiologicalProcess positive regulation of heart looping Any process that activates or increases the frequency, rate or extent of heart looping. go.json activation of cardiac looping|activation of heart looping|positive regulation of cardiac looping|up regulation of cardiac looping|up regulation of heart looping|up-regulation of cardiac looping|up-regulation of heart looping|upregulation of cardiac looping|upregulation of heart looping http://purl.obolibrary.org/obo/GO_1901209 GO:0046040 biolink:BiologicalProcess IMP metabolic process The chemical reactions and pathways involving IMP, inosine monophosphate. go.json IMP metabolism http://purl.obolibrary.org/obo/GO_0046040 GO:1901206 biolink:BiologicalProcess obsolete positive regulation of adrenergic receptor signaling pathway involved in heart process OBSOLETE. Any process that activates or increases the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway. go.json activation of adrenergic receptor signaling pathway involved in heart process|activation of adrenergic receptor signalling pathway involved in heart process|activation of beta-adrenergic receptor signalling pathway involved in heart process|positive regulation of adrenergic receptor signalling pathway involved in heart process|positive regulation of beta-adrenergic receptor signalling pathway involved in heart process|up regulation of adrenergic receptor signaling pathway involved in heart process|up regulation of adrenergic receptor signalling pathway involved in heart process|up regulation of beta-adrenergic receptor signalling pathway involved in heart process|up-regulation of adrenergic receptor signaling pathway involved in heart process|up-regulation of adrenergic receptor signalling pathway involved in heart process|up-regulation of beta-adrenergic receptor signalling pathway involved in heart process|upregulation of adrenergic receptor signaling pathway involved in heart process|upregulation of adrenergic receptor signalling pathway involved in heart process|upregulation of beta-adrenergic receptor signalling pathway involved in heart process True http://purl.obolibrary.org/obo/GO_1901206 GO:1901207 biolink:BiologicalProcess regulation of heart looping Any process that modulates the frequency, rate or extent of heart looping. go.json regulation of cardiac looping http://purl.obolibrary.org/obo/GO_1901207 GO:1901204 biolink:BiologicalProcess obsolete regulation of adrenergic receptor signaling pathway involved in heart process OBSOLETE. Any process that modulates the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway. go.json regulation of adrenergic receptor signalling pathway involved in heart process|regulation of beta-adrenergic receptor signalling pathway involved in heart process True http://purl.obolibrary.org/obo/GO_1901204 GO:1901205 biolink:BiologicalProcess obsolete negative regulation of adrenergic receptor signaling pathway involved in heart process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway. go.json down regulation of adrenergic receptor signaling pathway involved in heart process|down regulation of adrenergic receptor signalling pathway involved in heart process|down regulation of beta-adrenergic receptor signalling pathway involved in heart process|down-regulation of adrenergic receptor signaling pathway involved in heart process|down-regulation of adrenergic receptor signalling pathway involved in heart process|down-regulation of beta-adrenergic receptor signalling pathway involved in heart process|downregulation of adrenergic receptor signaling pathway involved in heart process|downregulation of adrenergic receptor signalling pathway involved in heart process|downregulation of beta-adrenergic receptor signalling pathway involved in heart process|inhibition of adrenergic receptor signaling pathway involved in heart process|inhibition of adrenergic receptor signalling pathway involved in heart process|inhibition of beta-adrenergic receptor signalling pathway involved in heart process|negative regulation of adrenergic receptor signalling pathway involved in heart process|negative regulation of beta-adrenergic receptor signalling pathway involved in heart process True http://purl.obolibrary.org/obo/GO_1901205 GO:1901202 biolink:BiologicalProcess negative regulation of extracellular matrix assembly Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. go.json down regulation of extracellular matrix assembly|down-regulation of extracellular matrix assembly|downregulation of extracellular matrix assembly|inhibition of extracellular matrix assembly http://purl.obolibrary.org/obo/GO_1901202 GO:0046049 biolink:BiologicalProcess UMP metabolic process The chemical reactions and pathways involving UMP, uridine monophosphate. go.json UMP metabolism http://purl.obolibrary.org/obo/GO_0046049 GO:1901203 biolink:BiologicalProcess positive regulation of extracellular matrix assembly Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. go.json activation of extracellular matrix assembly|up regulation of extracellular matrix assembly|up-regulation of extracellular matrix assembly|upregulation of extracellular matrix assembly http://purl.obolibrary.org/obo/GO_1901203 GO:0061680 biolink:BiologicalProcess Entner-Doudoroff pathway through gluconate to D-glyceraldehyde The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde. MetaCyc:NPGLUCAT-PWY go.json http://purl.obolibrary.org/obo/GO_0061680 GO:0046047 biolink:BiologicalProcess TTP catabolic process The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate. go.json TTP breakdown|TTP catabolism|TTP degradation|TTP hydrolysis http://purl.obolibrary.org/obo/GO_0046047 GO:1901200 biolink:BiologicalProcess negative regulation of calcium ion transport into cytosol involved in cellular response to salt stress Any negative regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress. go.json negative regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress|negative regulation of calcium ion transport into cytosol involved in cellular salinity response http://purl.obolibrary.org/obo/GO_1901200 GO:0061681 biolink:BiologicalProcess Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate. MetaCyc:PWY-2221 go.json http://purl.obolibrary.org/obo/GO_0061681 GO:1901201 biolink:BiologicalProcess regulation of extracellular matrix assembly Any process that modulates the frequency, rate or extent of extracellular matrix assembly. go.json http://purl.obolibrary.org/obo/GO_1901201 GO:0046048 biolink:BiologicalProcess UDP metabolic process The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate. go.json UDP metabolism http://purl.obolibrary.org/obo/GO_0046048 GO:0046045 biolink:BiologicalProcess TMP catabolic process The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate. go.json TMP breakdown|TMP catabolism|TMP degradation http://purl.obolibrary.org/obo/GO_0046045 GO:0061682 biolink:BiologicalProcess seminal vesicle morphogenesis The process in which the anatomical structures of a seminal vesicle are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061682 GO:0046046 biolink:BiologicalProcess TTP metabolic process The chemical reactions and pathways involving TTP, ribosylthymine triphosphate. go.json TTP metabolism http://purl.obolibrary.org/obo/GO_0046046 GO:0061683 biolink:BiologicalProcess branching involved in seminal vesicle morphogenesis The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem. go.json gonecyst branching morphogenesis|seminal gland branching morphogenesis|seminal vesicle branching|seminal vesicle branching morphogenesis http://purl.obolibrary.org/obo/GO_0061683 GO:0061684 biolink:BiologicalProcess chaperone-mediated autophagy The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded. Wikipedia:Chaperone-mediated_autophagy go.json CASA|CMA|chaperone-assisted selective autophagy http://purl.obolibrary.org/obo/GO_0061684 GO:0061685 biolink:MolecularActivity diphthine methylesterase activity Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol. EC:3.1.1.97|RHEA:42656 go.json http://purl.obolibrary.org/obo/GO_0061685 GO:0061686 biolink:MolecularActivity hercynylcysteine sulfoxide synthase activity Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O. EC:1.21.3.10|RHEA:42704 go.json hercynylcysteine S-oxide synthase|hercynylcysteine sulfoxide synthase http://purl.obolibrary.org/obo/GO_0061686 GO:0061687 biolink:BiologicalProcess detoxification of inorganic compound Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. go.json http://purl.obolibrary.org/obo/GO_0061687 GO:0061688 biolink:BiologicalProcess glycolytic process via Entner-Doudoroff Pathway A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes. go.json gluconate pathway http://purl.obolibrary.org/obo/GO_0061688 GO:0061689 biolink:CellularComponent tricellular tight junction An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0061689 GO:0071009 biolink:CellularComponent U4atac/U6atac x U5 tri-snRNP complex A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs. go.json U4atac/U6atac.U5 snRNP complex http://purl.obolibrary.org/obo/GO_0071009 GO:0071007 biolink:CellularComponent U2-type catalytic step 2 spliceosome A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. go.json GT-AG catalytic step 2 spliceosome|major catalytic step 2 spliceosome|mammalian U2-type spliceosomal complex C|mammalian U2-type spliceosomal complex C1|yeast U2-type spliceosomal complex A2-2 http://purl.obolibrary.org/obo/GO_0071007 GO:0071008 biolink:CellularComponent U2-type post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs. go.json GT-AG post-mRNA release spliceosomal complex|U2/U5/U6 snRNP complex|U2/U5/U6 tri-snRNP complex|major post-mRNA release spliceosomal complex|mammalian U2-type spliceosomal complex I http://purl.obolibrary.org/obo/GO_0071008 GO:0071005 biolink:CellularComponent U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. go.json GT-AG precatalytic spliceosome|major precatalytic spliceosome|mammalian U2-type spliceosomal complex B|mammalian U2-type spliceosomal complex B1|yeast U12-type spliceosomal complex A2-1 http://purl.obolibrary.org/obo/GO_0071005 GO:0071006 biolink:CellularComponent U2-type catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs. go.json GT-AG catalytic step 1 spliceosome|U2-type activated spliceosome|major catalytic step 1 spliceosome|mammalian U2-type spliceosomal complex B*|mammalian U2-type spliceosomal complex B2|yeast U2-type spliceosomal complex A1 http://purl.obolibrary.org/obo/GO_0071006 GO:0071003 biolink:CellularComponent penta-snRNP complex A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins. go.json penta-RNP complex http://purl.obolibrary.org/obo/GO_0071003 GO:0071004 biolink:CellularComponent U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. go.json GT-AG prespliceosome|major prespliceosome|mammalian U2-type spliceosomal complex A|yeast U2-type spliceosomal complex B http://purl.obolibrary.org/obo/GO_0071004 GO:0071001 biolink:CellularComponent U4/U6 snRNP A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes. go.json http://purl.obolibrary.org/obo/GO_0071001 GO:0071002 biolink:CellularComponent U4atac/U6atac snRNP A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes. go.json http://purl.obolibrary.org/obo/GO_0071002 GO:0046054 biolink:BiologicalProcess dGMP metabolic process The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). go.json dGMP metabolism http://purl.obolibrary.org/obo/GO_0046054 GO:0046055 biolink:BiologicalProcess dGMP catabolic process The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). go.json dGMP breakdown|dGMP catabolism|dGMP degradation http://purl.obolibrary.org/obo/GO_0046055 GO:0046052 biolink:BiologicalProcess UTP catabolic process The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate. go.json UTP breakdown|UTP catabolism|UTP degradation|UTP hydrolysis http://purl.obolibrary.org/obo/GO_0046052 GO:0046053 biolink:BiologicalProcess dAMP metabolic process The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). go.json dAMP metabolism http://purl.obolibrary.org/obo/GO_0046053 GO:0046050 biolink:BiologicalProcess UMP catabolic process The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. go.json UMP breakdown|UMP catabolism|UMP degradation http://purl.obolibrary.org/obo/GO_0046050 GO:1901219 biolink:BiologicalProcess regulation of cardiac chamber morphogenesis Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. go.json regulation of heart chamber morphogenesis http://purl.obolibrary.org/obo/GO_1901219 GO:0046051 biolink:BiologicalProcess UTP metabolic process The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. go.json UTP metabolism http://purl.obolibrary.org/obo/GO_0046051 GO:1901217 biolink:BiologicalProcess obsolete regulation of holin activity OBSOLETE. Any process that modulates the frequency, rate or extent of holin activity. go.json True http://purl.obolibrary.org/obo/GO_1901217 GO:1901218 biolink:BiologicalProcess obsolete negative regulation of holin activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of holin activity. go.json antiholin activity|down regulation of holin activity|down-regulation of holin activity|downregulation of holin activity|inhibition of holin activity|phage antiholin True http://purl.obolibrary.org/obo/GO_1901218 GO:1901215 biolink:BiologicalProcess obsolete negative regulation of neuron death OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. go.json down regulation of neuron cell death|down regulation of neuron death|down regulation of neuronal cell death|down-regulation of neuron cell death|down-regulation of neuron death|down-regulation of neuronal cell death|downregulation of neuron cell death|downregulation of neuron death|downregulation of neuronal cell death|inhibition of neuron cell death|inhibition of neuron death|inhibition of neuronal cell death|negative regulation of neuron cell death|negative regulation of neuronal cell death True http://purl.obolibrary.org/obo/GO_1901215 GO:1901216 biolink:BiologicalProcess obsolete positive regulation of neuron death OBSOLETE. Any process that activates or increases the frequency, rate or extent of neuron death. go.json activation of neuron cell death|activation of neuron death|activation of neuronal cell death|positive regulation of neuron cell death|positive regulation of neuronal cell death|up regulation of neuron cell death|up regulation of neuron death|up regulation of neuronal cell death|up-regulation of neuron cell death|up-regulation of neuron death|up-regulation of neuronal cell death|upregulation of neuron cell death|upregulation of neuron death|upregulation of neuronal cell death True http://purl.obolibrary.org/obo/GO_1901216 GO:1901213 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in heart development OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time. go.json global transcription regulation from Pol II promoter involved in cardiac development|global transcription regulation from Pol II promoter involved in dorsal vessel development|global transcription regulation from Pol II promoter involved in heart development|regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|regulation of global transcription from Pol II promoter involved in cardiac development|regulation of global transcription from Pol II promoter involved in dorsal vessel development|regulation of global transcription from Pol II promoter involved in heart development|regulation of transcription from Pol II promoter involved in cardiac development|regulation of transcription from Pol II promoter involved in dorsal vessel development|regulation of transcription from Pol II promoter involved in heart development|regulation of transcription from RNA polymerase II promoter involved in cardiac development|regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|regulation of transcription from RNA polymerase II promoter, global involved in heart development True http://purl.obolibrary.org/obo/GO_1901213 GO:1901214 biolink:BiologicalProcess obsolete regulation of neuron death OBSOLETE. Any process that modulates the frequency, rate or extent of neuron death. go.json regulation of neuron cell death|regulation of neuronal cell death True http://purl.obolibrary.org/obo/GO_1901214 GO:0046058 biolink:BiologicalProcess cAMP metabolic process The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json 3',5' cAMP metabolic process|3',5' cAMP metabolism|3',5'-cAMP metabolic process|3',5'-cAMP metabolism|adenosine 3',5'-cyclophosphate metabolic process|adenosine 3',5'-cyclophosphate metabolism|cAMP generating peptide activity|cAMP metabolism|cyclic AMP metabolic process|cyclic AMP metabolism http://purl.obolibrary.org/obo/GO_0046058 GO:1901211 biolink:BiologicalProcess negative regulation of cardiac chamber formation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. go.json down regulation of cardiac chamber formation|down regulation of heart chamber formation|down-regulation of cardiac chamber formation|down-regulation of heart chamber formation|downregulation of cardiac chamber formation|downregulation of heart chamber formation|inhibition of cardiac chamber formation|inhibition of heart chamber formation|negative regulation of heart chamber formation http://purl.obolibrary.org/obo/GO_1901211 GO:1901212 biolink:BiologicalProcess positive regulation of cardiac chamber formation Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. go.json activation of cardiac chamber formation|activation of heart chamber formation|positive regulation of heart chamber formation|up regulation of cardiac chamber formation|up regulation of heart chamber formation|up-regulation of cardiac chamber formation|up-regulation of heart chamber formation|upregulation of cardiac chamber formation|upregulation of heart chamber formation http://purl.obolibrary.org/obo/GO_1901212 GO:0046059 biolink:BiologicalProcess dAMP catabolic process The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). go.json dAMP breakdown|dAMP catabolism|dAMP degradation http://purl.obolibrary.org/obo/GO_0046059 GO:0061670 biolink:BiologicalProcess evoked neurotransmitter secretion Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential. go.json stimulus-dependant neurotransmitter secretion http://purl.obolibrary.org/obo/GO_0061670 GO:0061671 biolink:CellularComponent Cbp3p-Cbp6 complex A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly. go.json http://purl.obolibrary.org/obo/GO_0061671 GO:0046056 biolink:BiologicalProcess dADP metabolic process The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). go.json dADP metabolism http://purl.obolibrary.org/obo/GO_0046056 GO:1901210 biolink:BiologicalProcess regulation of cardiac chamber formation Any process that modulates the frequency, rate or extent of cardiac chamber formation. go.json regulation of heart chamber formation http://purl.obolibrary.org/obo/GO_1901210 GO:0061672 biolink:CellularComponent glutathione hydrolase complex Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly. go.json gamma-glutamyltranspeptidase complex|glutamine amidotransferase II complex|glutathionase complex http://purl.obolibrary.org/obo/GO_0061672 GO:0046057 biolink:BiologicalProcess dADP catabolic process The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). go.json dADP breakdown|dADP catabolism|dADP degradation http://purl.obolibrary.org/obo/GO_0046057 GO:0061673 biolink:CellularComponent mitotic spindle astral microtubule Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. go.json http://purl.obolibrary.org/obo/GO_0061673 GO:0061674 biolink:BiologicalProcess gap filling involved in double-strand break repair via nonhomologous end joining Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining. go.json http://purl.obolibrary.org/obo/GO_0061674 GO:0061675 biolink:MolecularActivity RBL family protein binding Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose. go.json rhamnose-binding lectin family protein binding http://purl.obolibrary.org/obo/GO_0061675 GO:0061676 biolink:MolecularActivity importin-alpha family protein binding Binding to a member of the importin-alpha family. go.json http://purl.obolibrary.org/obo/GO_0061676 GO:0061677 biolink:MolecularActivity 2-dehydro-3-deoxy-D-gluconate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde. EC:4.1.2.51|MetaCyc:DHDOGALDOL-RXN|RHEA:35583 go.json 2-keto-3-deoxygluconate aldolase activity|KDG aldolase activity http://purl.obolibrary.org/obo/GO_0061677 GO:0061678 biolink:BiologicalProcess Entner-Doudoroff pathway A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate. MetaCyc:Entner-Doudoroff-Pathways go.json http://purl.obolibrary.org/obo/GO_0061678 GO:0061679 biolink:BiologicalProcess Entner-Doudoroff pathway through gluconate The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate. go.json gluconate pathway http://purl.obolibrary.org/obo/GO_0061679 GO:0071021 biolink:CellularComponent U2-type post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6. go.json GT-AG post-spliceosomal complex|major post-spliceosomal complex|mammalian U2-type spliceosomal complex C2|yeast U2-type spliceosomal complex A2-3 http://purl.obolibrary.org/obo/GO_0071021 GO:0046065 biolink:BiologicalProcess dCTP metabolic process The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate. go.json dCTP metabolism http://purl.obolibrary.org/obo/GO_0046065 GO:0071022 biolink:CellularComponent U12-type post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac. go.json AT-AC post-spliceosomal complex|mammalian U12-type spliceosomal complex C2|minor post-spliceosomal complex|yeast U12-type spliceosomal complex A2-3 http://purl.obolibrary.org/obo/GO_0071022 GO:0046066 biolink:BiologicalProcess dGDP metabolic process The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). go.json dGDP metabolism http://purl.obolibrary.org/obo/GO_0046066 GO:0046063 biolink:BiologicalProcess dCMP metabolic process The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate. go.json dCMP metabolism http://purl.obolibrary.org/obo/GO_0046063 GO:0046064 biolink:BiologicalProcess dCMP biosynthetic process The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate. go.json dCMP anabolism|dCMP biosynthesis|dCMP formation|dCMP synthesis http://purl.obolibrary.org/obo/GO_0046064 GO:0071020 biolink:CellularComponent post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5. go.json mammalian spliceosomal complex C2|yeast spliceosomal complex A2-3 http://purl.obolibrary.org/obo/GO_0071020 GO:0046061 biolink:BiologicalProcess dATP catabolic process The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). go.json dATP breakdown|dATP catabolism|dATP degradation http://purl.obolibrary.org/obo/GO_0046061 GO:0046062 biolink:BiologicalProcess dCDP metabolic process The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate. go.json dCDP metabolism http://purl.obolibrary.org/obo/GO_0046062 GO:1901228 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development. go.json activation of global transcription from RNA polymerase II promoter involved in cardiac development|activation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|activation of global transcription from RNA polymerase II promoter involved in heart development|activation of transcription from RNA polymerase II promoter involved in cardiac development|activation of transcription from RNA polymerase II promoter involved in dorsal vessel development|activation of transcription from RNA polymerase II promoter involved in heart development|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|positive regulation of global transcription from Pol II promoter involved in cardiac development|positive regulation of global transcription from Pol II promoter involved in dorsal vessel development|positive regulation of global transcription from Pol II promoter involved in heart development|positive regulation of transcription from Pol II promoter involved in cardiac development|positive regulation of transcription from Pol II promoter involved in dorsal vessel development|positive regulation of transcription from Pol II promoter involved in heart development|positive regulation of transcription from RNA polymerase II promoter involved in cardiac development|positive regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|stimulation of global transcription from RNA polymerase II promoter involved in cardiac development|stimulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|stimulation of global transcription from RNA polymerase II promoter involved in heart development|stimulation of transcription from RNA polymerase II promoter involved in cardiac development|stimulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|stimulation of transcription from RNA polymerase II promoter involved in heart development|up regulation of global transcription from RNA polymerase II promoter involved in cardiac development|up regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|up regulation of global transcription from RNA polymerase II promoter involved in heart development|up regulation of transcription from RNA polymerase II promoter involved in cardiac development|up regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|up regulation of transcription from RNA polymerase II promoter involved in heart development|up-regulation of global transcription from RNA polymerase II promoter involved in cardiac development|up-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|up-regulation of global transcription from RNA polymerase II promoter involved in heart development|up-regulation of transcription from RNA polymerase II promoter involved in cardiac development|up-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|up-regulation of transcription from RNA polymerase II promoter involved in heart development|upregulation of global transcription from RNA polymerase II promoter involved in cardiac development|upregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|upregulation of global transcription from RNA polymerase II promoter involved in heart development|upregulation of transcription from RNA polymerase II promoter involved in cardiac development|upregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|upregulation of transcription from RNA polymerase II promoter involved in heart development True http://purl.obolibrary.org/obo/GO_1901228 GO:1901229 biolink:BiologicalProcess regulation of non-canonical Wnt signaling pathway via JNK cascade Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade. go.json regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|regulation of non-canonical Wnt-activated signaling pathway via JNK cascade http://purl.obolibrary.org/obo/GO_1901229 GO:0046060 biolink:BiologicalProcess dATP metabolic process The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). go.json dATP metabolism http://purl.obolibrary.org/obo/GO_0046060 GO:1901226 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development. go.json activation of global transcription regulation from Pol II promoter involved in cardiac development|activation of global transcription regulation from Pol II promoter involved in dorsal vessel development|activation of global transcription regulation from Pol II promoter involved in heart development|activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|activation of regulation of global transcription from Pol II promoter involved in cardiac development|activation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|activation of regulation of global transcription from Pol II promoter involved in heart development|activation of regulation of transcription from Pol II promoter involved in cardiac development|activation of regulation of transcription from Pol II promoter involved in dorsal vessel development|activation of regulation of transcription from Pol II promoter involved in heart development|activation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|activation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|activation of regulation of transcription from RNA polymerase II promoter involved in heart development|activation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|activation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|activation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|positive regulation of global transcription regulation from Pol II promoter involved in cardiac development|positive regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|positive regulation of global transcription regulation from Pol II promoter involved in heart development|positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|positive regulation of regulation of global transcription from Pol II promoter involved in cardiac development|positive regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|positive regulation of regulation of global transcription from Pol II promoter involved in heart development|positive regulation of regulation of transcription from Pol II promoter involved in cardiac development|positive regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|positive regulation of regulation of transcription from Pol II promoter involved in heart development|positive regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|positive regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|positive regulation of transcription from RNA polymerase II promoter involved in heart development|up regulation of global transcription regulation from Pol II promoter involved in cardiac development|up regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|up regulation of global transcription regulation from Pol II promoter involved in heart development|up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|up regulation of regulation of global transcription from Pol II promoter involved in cardiac development|up regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|up regulation of regulation of global transcription from Pol II promoter involved in heart development|up regulation of regulation of transcription from Pol II promoter involved in cardiac development|up regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|up regulation of regulation of transcription from Pol II promoter involved in heart development|up regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|up regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|up regulation of regulation of transcription from RNA polymerase II promoter involved in heart development|up regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|up regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|up regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|up-regulation of global transcription regulation from Pol II promoter involved in cardiac development|up-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|up-regulation of global transcription regulation from Pol II promoter involved in heart development|up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|up-regulation of regulation of global transcription from Pol II promoter involved in cardiac development|up-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|up-regulation of regulation of global transcription from Pol II promoter involved in heart development|up-regulation of regulation of transcription from Pol II promoter involved in cardiac development|up-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|up-regulation of regulation of transcription from Pol II promoter involved in heart development|up-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|up-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|up-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development|up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|upregulation of global transcription regulation from Pol II promoter involved in cardiac development|upregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|upregulation of global transcription regulation from Pol II promoter involved in heart development|upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|upregulation of regulation of global transcription from Pol II promoter involved in cardiac development|upregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|upregulation of regulation of global transcription from Pol II promoter involved in heart development|upregulation of regulation of transcription from Pol II promoter involved in cardiac development|upregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|upregulation of regulation of transcription from Pol II promoter involved in heart development|upregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|upregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|upregulation of regulation of transcription from RNA polymerase II promoter involved in heart development|upregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|upregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|upregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development True http://purl.obolibrary.org/obo/GO_1901226 GO:1901227 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development. go.json down regulation of global transcription from RNA polymerase II promoter involved in cardiac development|down regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|down regulation of global transcription from RNA polymerase II promoter involved in heart development|down regulation of transcription from RNA polymerase II promoter involved in cardiac development|down regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|down regulation of transcription from RNA polymerase II promoter involved in heart development|down-regulation of global transcription from RNA polymerase II promoter involved in cardiac development|down-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|down-regulation of global transcription from RNA polymerase II promoter involved in heart development|down-regulation of transcription from RNA polymerase II promoter involved in cardiac development|down-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|down-regulation of transcription from RNA polymerase II promoter involved in heart development|downregulation of global transcription from RNA polymerase II promoter involved in cardiac development|downregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development|downregulation of global transcription from RNA polymerase II promoter involved in heart development|downregulation of transcription from RNA polymerase II promoter involved in cardiac development|downregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|downregulation of transcription from RNA polymerase II promoter involved in heart development|inhibition of global transcription from RNA polymerase II promoter involved in cardiac development|inhibition of global transcription from RNA polymerase II promoter involved in dorsal vessel development|inhibition of global transcription from RNA polymerase II promoter involved in heart development|inhibition of transcription from RNA polymerase II promoter involved in cardiac development|inhibition of transcription from RNA polymerase II promoter involved in dorsal vessel development|inhibition of transcription from RNA polymerase II promoter involved in heart development|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|negative regulation of global transcription from Pol II promoter involved in cardiac development|negative regulation of global transcription from Pol II promoter involved in dorsal vessel development|negative regulation of global transcription from Pol II promoter involved in heart development|negative regulation of transcription from Pol II promoter involved in cardiac development|negative regulation of transcription from Pol II promoter involved in dorsal vessel development|negative regulation of transcription from Pol II promoter involved in heart development|negative regulation of transcription from RNA polymerase II promoter involved in cardiac development|negative regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development True http://purl.obolibrary.org/obo/GO_1901227 GO:1901224 biolink:BiologicalProcess positive regulation of non-canonical NF-kappaB signal transduction Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade. go.json activation of NIK/NF-kappaB cascade|activation of non-canonical NF-KB signaling|activation of noncanonical NF-kappaB signaling|activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|activation of p52-dependent NF-kappaB signaling|positive regulation of NF-kappaB import into nucleus|positive regulation of NIK/NF-kappaB cascade|positive regulation of NIK/NF-kappaB signaling|positive regulation of non-canonical NF-KB signaling|positive regulation of noncanonical NF-kappaB signaling|positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|positive regulation of p52-dependent NF-kappaB signaling|up regulation of NIK/NF-kappaB cascade|up regulation of non-canonical NF-KB signaling|up regulation of noncanonical NF-kappaB signaling|up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|up regulation of p52-dependent NF-kappaB signaling|up-regulation of NIK/NF-kappaB cascade|up-regulation of non-canonical NF-KB signaling|up-regulation of noncanonical NF-kappaB signaling|up-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|up-regulation of p52-dependent NF-kappaB signaling|upregulation of NIK/NF-kappaB cascade|upregulation of non-canonical NF-KB signaling|upregulation of noncanonical NF-kappaB signaling|upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|upregulation of p52-dependent NF-kappaB signaling http://purl.obolibrary.org/obo/GO_1901224 GO:1901225 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development. go.json down regulation of global transcription regulation from Pol II promoter involved in cardiac development|down regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|down regulation of global transcription regulation from Pol II promoter involved in heart development|down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|down regulation of regulation of global transcription from Pol II promoter involved in cardiac development|down regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|down regulation of regulation of global transcription from Pol II promoter involved in heart development|down regulation of regulation of transcription from Pol II promoter involved in cardiac development|down regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|down regulation of regulation of transcription from Pol II promoter involved in heart development|down regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|down regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|down regulation of regulation of transcription from RNA polymerase II promoter involved in heart development|down regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|down regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|down regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|down-regulation of global transcription regulation from Pol II promoter involved in cardiac development|down-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|down-regulation of global transcription regulation from Pol II promoter involved in heart development|down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|down-regulation of regulation of global transcription from Pol II promoter involved in cardiac development|down-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|down-regulation of regulation of global transcription from Pol II promoter involved in heart development|down-regulation of regulation of transcription from Pol II promoter involved in cardiac development|down-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|down-regulation of regulation of transcription from Pol II promoter involved in heart development|down-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|down-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|down-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development|down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|downregulation of global transcription regulation from Pol II promoter involved in cardiac development|downregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|downregulation of global transcription regulation from Pol II promoter involved in heart development|downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|downregulation of regulation of global transcription from Pol II promoter involved in cardiac development|downregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|downregulation of regulation of global transcription from Pol II promoter involved in heart development|downregulation of regulation of transcription from Pol II promoter involved in cardiac development|downregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|downregulation of regulation of transcription from Pol II promoter involved in heart development|downregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|downregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|downregulation of regulation of transcription from RNA polymerase II promoter involved in heart development|downregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|downregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|downregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|inhibition of global transcription regulation from Pol II promoter involved in cardiac development|inhibition of global transcription regulation from Pol II promoter involved in dorsal vessel development|inhibition of global transcription regulation from Pol II promoter involved in heart development|inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|inhibition of regulation of global transcription from Pol II promoter involved in cardiac development|inhibition of regulation of global transcription from Pol II promoter involved in dorsal vessel development|inhibition of regulation of global transcription from Pol II promoter involved in heart development|inhibition of regulation of transcription from Pol II promoter involved in cardiac development|inhibition of regulation of transcription from Pol II promoter involved in dorsal vessel development|inhibition of regulation of transcription from Pol II promoter involved in heart development|inhibition of regulation of transcription from RNA polymerase II promoter involved in cardiac development|inhibition of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|inhibition of regulation of transcription from RNA polymerase II promoter involved in heart development|inhibition of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|inhibition of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|inhibition of regulation of transcription from RNA polymerase II promoter, global involved in heart development|negative regulation of global transcription regulation from Pol II promoter involved in cardiac development|negative regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development|negative regulation of global transcription regulation from Pol II promoter involved in heart development|negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development|negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development|negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development|negative regulation of regulation of global transcription from Pol II promoter involved in cardiac development|negative regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development|negative regulation of regulation of global transcription from Pol II promoter involved in heart development|negative regulation of regulation of transcription from Pol II promoter involved in cardiac development|negative regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development|negative regulation of regulation of transcription from Pol II promoter involved in heart development|negative regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development|negative regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development|negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development|negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development|negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development|negative regulation of transcription from RNA polymerase II promoter involved in heart development True http://purl.obolibrary.org/obo/GO_1901225 GO:1901222 biolink:BiologicalProcess regulation of non-canonical NF-kappaB signal transduction Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade. go.json NF-KB import into nucleus|NF-kappaB import into nucleus|regulation of NF-kappaB import into nucleus|regulation of NIK/NF-kappaB cascade|regulation of NIK/NF-kappaB signaling|regulation of non-canonical NF-KB signaling|regulation of noncanonical NF-kappaB signaling|regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|regulation of p52-dependent NF-kappaB signaling http://purl.obolibrary.org/obo/GO_1901222 GO:0046069 biolink:BiologicalProcess cGMP catabolic process The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate. go.json cGMP breakdown|cGMP catabolism|cGMP degradation http://purl.obolibrary.org/obo/GO_0046069 GO:1901223 biolink:BiologicalProcess negative regulation of non-canonical NF-kappaB signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade. go.json down regulation of NIK/NF-kappaB cascade|down regulation of non-canonical NF-KB signaling|down regulation of noncanonical NF-kappaB signaling|down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|down regulation of p52-dependent NF-kappaB signaling|down-regulation of NIK/NF-kappaB cascade|down-regulation of non-canonical NF-KB signaling|down-regulation of noncanonical NF-kappaB signaling|down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|down-regulation of p52-dependent NF-kappaB signaling|downregulation of NIK/NF-kappaB cascade|downregulation of non-canonical NF-KB signaling|downregulation of noncanonical NF-kappaB signaling|downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|downregulation of p52-dependent NF-kappaB signaling|inhibition of NIK/NF-kappaB cascade|inhibition of non-canonical NF-KB signaling|inhibition of noncanonical NF-kappaB signaling|inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway|inhibition of p52-dependent NF-kappaB signaling|negative regulation of NF-kappaB import into nucleus|negative regulation of NIK/NF-kappaB cascade|negative regulation of NIK/NF-kappaB signaling|negative regulation of non-canonical NF-KB signaling|negative regulation of noncanonical NF-kappaB signaling|negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|negative regulation of p52-dependent NF-kappaB signaling http://purl.obolibrary.org/obo/GO_1901223 GO:1901220 biolink:BiologicalProcess negative regulation of cardiac chamber morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. go.json down regulation of cardiac chamber morphogenesis|down regulation of heart chamber morphogenesis|down-regulation of cardiac chamber morphogenesis|down-regulation of heart chamber morphogenesis|downregulation of cardiac chamber morphogenesis|downregulation of heart chamber morphogenesis|inhibition of cardiac chamber morphogenesis|inhibition of heart chamber morphogenesis|negative regulation of heart chamber morphogenesis http://purl.obolibrary.org/obo/GO_1901220 GO:0046067 biolink:BiologicalProcess dGDP catabolic process The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). go.json dGDP breakdown|dGDP catabolism|dGDP degradation http://purl.obolibrary.org/obo/GO_0046067 GO:0046068 biolink:BiologicalProcess cGMP metabolic process The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. go.json cGMP metabolism http://purl.obolibrary.org/obo/GO_0046068 GO:1901221 biolink:BiologicalProcess positive regulation of cardiac chamber morphogenesis Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. go.json activation of cardiac chamber morphogenesis|activation of heart chamber morphogenesis|positive regulation of heart chamber morphogenesis|up regulation of cardiac chamber morphogenesis|up regulation of heart chamber morphogenesis|up-regulation of cardiac chamber morphogenesis|up-regulation of heart chamber morphogenesis|upregulation of cardiac chamber morphogenesis|upregulation of heart chamber morphogenesis http://purl.obolibrary.org/obo/GO_1901221 GO:1901230 biolink:BiologicalProcess negative regulation of non-canonical Wnt signaling pathway via JNK cascade Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade. go.json down regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|down regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|down-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|down-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|downregulation of non-canonical Wnt receptor signaling pathway via JNK cascade|downregulation of non-canonical Wnt receptor signalling pathway via JNK cascade|inhibition of non-canonical Wnt receptor signaling pathway via JNK cascade|inhibition of non-canonical Wnt receptor signalling pathway via JNK cascade|negative regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|negative regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|negative regulation of non-canonical Wnt-activated signaling pathway via JNK cascade http://purl.obolibrary.org/obo/GO_1901230 GO:0071029 biolink:BiologicalProcess nuclear ncRNA surveillance The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus. go.json nuclear aberrant ncRNA catabolic process|nuclear ncRNA quality control http://purl.obolibrary.org/obo/GO_0071029 GO:0071027 biolink:BiologicalProcess nuclear RNA surveillance A process that identifies and degrades defective or aberrant RNAs within the nucleus. go.json nuclear RNA quality control|nuclear aberrant RNA catabolic process http://purl.obolibrary.org/obo/GO_0071027 GO:0071028 biolink:BiologicalProcess nuclear mRNA surveillance A process that identifies and degrades defective or aberrant mRNAs within the nucleus. go.json nuclear aberrant mRNA catabolic process|nuclear mRNA quality control|nuclear retention of pre-mRNA at the site of transcription|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|nuclear retention of unspliced pre-mRNA at the site of transcription http://purl.obolibrary.org/obo/GO_0071028 GO:0071025 biolink:BiologicalProcess RNA surveillance A process that identifies and degrades defective or aberrant RNAs. go.json RNA quality control|aberrant RNA catabolic process http://purl.obolibrary.org/obo/GO_0071025 GO:0071026 biolink:BiologicalProcess cytoplasmic RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm. go.json cytoplasmic RNA quality control|cytoplasmic aberrant RNA catabolic process http://purl.obolibrary.org/obo/GO_0071026 GO:0071023 biolink:CellularComponent trans spliceosomal complex A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates. go.json http://purl.obolibrary.org/obo/GO_0071023 GO:0071024 biolink:CellularComponent SL snRNP A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins. go.json http://purl.obolibrary.org/obo/GO_0071024 GO:0071010 biolink:CellularComponent prespliceosome A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. go.json mammalian spliceosomal complex A|prespliceosomal complex|yeast spliceosomal complex B http://purl.obolibrary.org/obo/GO_0071010 GO:0046076 biolink:BiologicalProcess dTTP catabolic process The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate. go.json dTTP breakdown|dTTP catabolism|dTTP degradation http://purl.obolibrary.org/obo/GO_0046076 GO:0071011 biolink:CellularComponent precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. go.json mammalian spliceosomal complex B|mammalian spliceosomal complex B1|yeast spliceosomal complex A2-1 http://purl.obolibrary.org/obo/GO_0071011 GO:0046077 biolink:BiologicalProcess dUDP metabolic process The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate. go.json dUDP metabolism http://purl.obolibrary.org/obo/GO_0046077 GO:0046074 biolink:BiologicalProcess dTMP catabolic process The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate. go.json dTMP breakdown|dTMP catabolism|dTMP degradation http://purl.obolibrary.org/obo/GO_0046074 GO:0046075 biolink:BiologicalProcess dTTP metabolic process The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate. go.json dTTP metabolism http://purl.obolibrary.org/obo/GO_0046075 GO:0046072 biolink:BiologicalProcess dTDP metabolic process The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate. go.json dTDP metabolism http://purl.obolibrary.org/obo/GO_0046072 GO:0046073 biolink:BiologicalProcess dTMP metabolic process The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). go.json dTMP metabolism http://purl.obolibrary.org/obo/GO_0046073 GO:1901239 biolink:MolecularActivity malonate(1-) transmembrane transporter activity Enables the transfer of malonate(1-) from one side of a membrane to the other. RHEA:33115 go.json malonic acid uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901239 GO:0046070 biolink:BiologicalProcess dGTP metabolic process The chemical reactions and pathways involving dGTP, guanosine triphosphate. go.json dGTP metabolism http://purl.obolibrary.org/obo/GO_0046070 GO:0046071 biolink:BiologicalProcess dGTP biosynthetic process The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate. go.json dGTP anabolism|dGTP biosynthesis|dGTP formation|dGTP synthesis http://purl.obolibrary.org/obo/GO_0046071 GO:1901237 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901237 GO:1901238 biolink:MolecularActivity ABC-type tungstate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out). EC:7.3.2.6|RHEA:35027 go.json ATPase-coupled tungstate transmembrane transporter activity|tungstate transmembrane transporter activity|tungstate transmembrane-transporting ATPase activity http://purl.obolibrary.org/obo/GO_1901238 GO:1901235 biolink:MolecularActivity (R)-carnitine transmembrane transporter activity Enables the transfer of (R)-carnitine from one side of a membrane to the other. RHEA:34959 go.json http://purl.obolibrary.org/obo/GO_1901235 GO:1901236 biolink:MolecularActivity 4-(trimethylammonio)butanoate transmembrane transporter activity Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other. RHEA:32835 go.json http://purl.obolibrary.org/obo/GO_1901236 GO:0061690 biolink:MolecularActivity lipoamidase activity Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein. MetaCyc:RXN-13031 go.json lipoyl-X-hydrolase http://purl.obolibrary.org/obo/GO_0061690 GO:0061691 biolink:BiologicalProcess detoxification of hydrogen peroxide Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration. go.json http://purl.obolibrary.org/obo/GO_0061691 GO:1901233 biolink:BiologicalProcess negative regulation of convergent extension involved in axis elongation Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation. go.json down regulation of convergent extension involved in axis elongation|down-regulation of convergent extension involved in axis elongation|downregulation of convergent extension involved in axis elongation|inhibition of convergent extension involved in axis elongation http://purl.obolibrary.org/obo/GO_1901233 GO:1901234 biolink:BiologicalProcess positive regulation of convergent extension involved in axis elongation Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation. go.json activation of convergent extension involved in axis elongation|up regulation of convergent extension involved in axis elongation|up-regulation of convergent extension involved in axis elongation|upregulation of convergent extension involved in axis elongation http://purl.obolibrary.org/obo/GO_1901234 GO:0061692 biolink:BiologicalProcess cellular detoxification of hydrogen peroxide Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration. go.json http://purl.obolibrary.org/obo/GO_0061692 GO:1901231 biolink:BiologicalProcess positive regulation of non-canonical Wnt signaling pathway via JNK cascade Any process that activates or increases the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade. go.json activation of non-canonical Wnt receptor signaling pathway via JNK cascade|activation of non-canonical Wnt receptor signalling pathway via JNK cascade|positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|positive regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|positive regulation of non-canonical Wnt-activated signaling pathway via JNK cascade|up regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|up regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|up-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade|up-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade|upregulation of non-canonical Wnt receptor signaling pathway via JNK cascade|upregulation of non-canonical Wnt receptor signalling pathway via JNK cascade http://purl.obolibrary.org/obo/GO_1901231 GO:0061693 biolink:MolecularActivity alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine. EC:2.7.8.37|MetaCyc:RXN0-6732|RHEA:34679 go.json http://purl.obolibrary.org/obo/GO_0061693 GO:0046078 biolink:BiologicalProcess dUMP metabolic process The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate). go.json dUMP metabolism http://purl.obolibrary.org/obo/GO_0046078 GO:0046079 biolink:BiologicalProcess dUMP catabolic process The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate. go.json dUMP breakdown|dUMP catabolism|dUMP degradation http://purl.obolibrary.org/obo/GO_0046079 GO:1901232 biolink:BiologicalProcess regulation of convergent extension involved in axis elongation Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation. go.json http://purl.obolibrary.org/obo/GO_1901232 GO:0061694 biolink:CellularComponent alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity. go.json http://purl.obolibrary.org/obo/GO_0061694 GO:0061695 biolink:CellularComponent transferase complex, transferring phosphorus-containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). go.json http://purl.obolibrary.org/obo/GO_0061695 GO:1901240 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901240 GO:0061696 biolink:CellularComponent pituitary gonadotropin complex A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function. go.json http://purl.obolibrary.org/obo/GO_0061696 GO:1901241 biolink:MolecularActivity 4-hydroxyphenylacetate transmembrane transporter activity Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other. RHEA:33175 go.json http://purl.obolibrary.org/obo/GO_1901241 GO:0061697 biolink:MolecularActivity protein-glutaryllysine deglutarylase activity Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:47664 go.json http://purl.obolibrary.org/obo/GO_0061697 GO:0061698 biolink:BiologicalProcess protein deglutarylation The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0061698 gocheck_do_not_annotate GO:0061699 biolink:BiologicalProcess peptidyl-lysine deglutarylation The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0061699 gocheck_do_not_annotate GO:0071018 biolink:CellularComponent U12-type catalytic step 2 spliceosome A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs. go.json AT-AC catalytic step 2 spliceosome|mammalian U12-type spliceosomal complex C|mammalian U12-type spliceosomal complex C1|minor catalytic step 2 spliceosome|yeast U12-type spliceosomal complex A2-2 http://purl.obolibrary.org/obo/GO_0071018 GO:0046080 biolink:BiologicalProcess dUTP metabolic process The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. go.json dUTP metabolism http://purl.obolibrary.org/obo/GO_0046080 GO:0071019 biolink:CellularComponent U12-type post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs. go.json AT-AC post-mRNA release spliceosomal complex|mammalian U12-type spliceosomal complex I|minor post-mRNA release spliceosomal complex http://purl.obolibrary.org/obo/GO_0071019 GO:0071016 biolink:CellularComponent U12-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs. go.json AT-AC precatalytic spliceosome|mammalian U12-type spliceosomal complex B|mammalian U12-type spliceosomal complex B1|minor precatalytic spliceosome|yeast U12-type spliceosomal complex A2-1 http://purl.obolibrary.org/obo/GO_0071016 GO:0071017 biolink:CellularComponent U12-type catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs. go.json AT-AC catalytic step 1 spliceosome|U12-type activated spliceosome|mammalian U12-type spliceosomal complex B*|mammalian U12-type spliceosomal complex B2|minor catalytic step 1 spliceosome|yeast U12-type spliceosomal complex A1 http://purl.obolibrary.org/obo/GO_0071017 GO:0071014 biolink:CellularComponent post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac. go.json mammalian spliceosomal complex I http://purl.obolibrary.org/obo/GO_0071014 GO:0071015 biolink:CellularComponent U12-type prespliceosome A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. go.json AT-AC prespliceosome|mammalian U12-type spliceosomal complex A|minor prespliceosome|yeast U12-type spliceosomal complex B http://purl.obolibrary.org/obo/GO_0071015 GO:0071012 biolink:CellularComponent catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs. go.json activated spliceosome|mammalian spliceosomal complex B*|mammalian spliceosomal complex B2|yeast spliceosomal complex A1 http://purl.obolibrary.org/obo/GO_0071012 GO:0071013 biolink:CellularComponent catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. go.json mammalian spliceosomal complex C|mammalian spliceosomal complex C1|yeast spliceosomal complex A2-2 http://purl.obolibrary.org/obo/GO_0071013 GO:0022032 biolink:BiologicalProcess telencephalon oligodendrocyte cell migration The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0022032 GO:0071043 biolink:BiologicalProcess CUT metabolic process The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome. go.json http://purl.obolibrary.org/obo/GO_0071043 GO:0046087 biolink:BiologicalProcess cytidine metabolic process The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside. go.json cytidine metabolism http://purl.obolibrary.org/obo/GO_0046087 GO:0071044 biolink:BiologicalProcess histone mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). go.json http://purl.obolibrary.org/obo/GO_0071044 GO:0022033 biolink:BiologicalProcess telencephalon microglial cell migration The orderly movement of microglial cells through the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0022033 GO:0046088 biolink:BiologicalProcess cytidine biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside. go.json cytidine anabolism|cytidine biosynthesis|cytidine formation|cytidine synthesis http://purl.obolibrary.org/obo/GO_0046088 GO:0071041 biolink:BiologicalProcess antisense RNA transcript catabolic process The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product. go.json http://purl.obolibrary.org/obo/GO_0071041 GO:0022034 biolink:BiologicalProcess rhombomere cell proliferation The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population. go.json http://purl.obolibrary.org/obo/GO_0022034 GO:0046085 biolink:BiologicalProcess adenosine metabolic process The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. go.json adenosine metabolism http://purl.obolibrary.org/obo/GO_0046085 GO:0071042 biolink:BiologicalProcess nuclear polyadenylation-dependent mRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. go.json nuclear poly(A)-dependent mRNA catabolic process http://purl.obolibrary.org/obo/GO_0071042 GO:0022035 biolink:BiologicalProcess rhombomere cell migration The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. go.json http://purl.obolibrary.org/obo/GO_0022035 GO:0046086 biolink:BiologicalProcess adenosine biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. go.json adenosine anabolism|adenosine biosynthesis|adenosine formation|adenosine synthesis http://purl.obolibrary.org/obo/GO_0046086 GO:0046083 biolink:BiologicalProcess adenine metabolic process The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. go.json adenine metabolism http://purl.obolibrary.org/obo/GO_0046083 GO:0022036 biolink:BiologicalProcess rhombomere cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell. go.json http://purl.obolibrary.org/obo/GO_0022036 GO:0046084 biolink:BiologicalProcess adenine biosynthetic process The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. go.json adenine anabolism|adenine biosynthesis|adenine formation|adenine synthesis http://purl.obolibrary.org/obo/GO_0046084 GO:0022037 biolink:BiologicalProcess metencephalon development The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0022037 GO:0071040 biolink:BiologicalProcess nuclear polyadenylation-dependent antisense transcript catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript. go.json nuclear poly(A)-dependent antisense transcript catabolic process http://purl.obolibrary.org/obo/GO_0071040 GO:0046081 biolink:BiologicalProcess dUTP catabolic process The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. go.json dUTP breakdown|dUTP catabolism|dUTP degradation http://purl.obolibrary.org/obo/GO_0046081 GO:0022038 biolink:BiologicalProcess corpus callosum development The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. go.json http://purl.obolibrary.org/obo/GO_0022038 GO:0046082 biolink:BiologicalProcess 5-methylcytosine biosynthetic process The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA. go.json 5-methylcytosine anabolism|5-methylcytosine biosynthesis|5-methylcytosine formation|5-methylcytosine synthesis http://purl.obolibrary.org/obo/GO_0046082 GO:1901248 biolink:BiologicalProcess positive regulation of lung ciliated cell differentiation Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. go.json activation of lung ciliated cell differentiation|up regulation of lung ciliated cell differentiation|up-regulation of lung ciliated cell differentiation|upregulation of lung ciliated cell differentiation http://purl.obolibrary.org/obo/GO_1901248 GO:1901249 biolink:BiologicalProcess regulation of lung goblet cell differentiation Any process that modulates the frequency, rate or extent of lung goblet cell differentiation. go.json regulation of pulmonary goblet cell differentiation http://purl.obolibrary.org/obo/GO_1901249 GO:1901246 biolink:BiologicalProcess regulation of lung ciliated cell differentiation Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1901246 GO:1901247 biolink:BiologicalProcess negative regulation of lung ciliated cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. go.json down regulation of lung ciliated cell differentiation|down-regulation of lung ciliated cell differentiation|downregulation of lung ciliated cell differentiation|inhibition of lung ciliated cell differentiation http://purl.obolibrary.org/obo/GO_1901247 GO:1901244 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter to protect the cell or organism in response to the presence of a fungus. go.json activation of global transcription from RNA polymerase II promoter involved in defence response to fungi|activation of global transcription from RNA polymerase II promoter involved in defence response to fungus|activation of global transcription from RNA polymerase II promoter involved in defense response to fungi|activation of global transcription from RNA polymerase II promoter involved in defense response to fungus|activation of transcription from RNA polymerase II promoter involved in defence response to fungi|activation of transcription from RNA polymerase II promoter involved in defence response to fungus|activation of transcription from RNA polymerase II promoter involved in defense response to fungi|activation of transcription from RNA polymerase II promoter involved in defense response to fungus|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungi|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungus|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungi|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungus|positive regulation of global transcription from Pol II promoter involved in defence response to fungi|positive regulation of global transcription from Pol II promoter involved in defence response to fungus|positive regulation of global transcription from Pol II promoter involved in defense response to fungi|positive regulation of global transcription from Pol II promoter involved in defense response to fungus|positive regulation of transcription from Pol II promoter involved in defence response to fungi|positive regulation of transcription from Pol II promoter involved in defence response to fungus|positive regulation of transcription from Pol II promoter involved in defense response to fungi|positive regulation of transcription from Pol II promoter involved in defense response to fungus|positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungi|positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungus|positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungi|stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungi|stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungus|stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungi|stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungus|stimulation of transcription from RNA polymerase II promoter involved in defence response to fungi|stimulation of transcription from RNA polymerase II promoter involved in defence response to fungus|stimulation of transcription from RNA polymerase II promoter involved in defense response to fungi|stimulation of transcription from RNA polymerase II promoter involved in defense response to fungus|up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi|up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus|up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi|up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus|up regulation of transcription from RNA polymerase II promoter involved in defence response to fungi|up regulation of transcription from RNA polymerase II promoter involved in defence response to fungus|up regulation of transcription from RNA polymerase II promoter involved in defense response to fungi|up regulation of transcription from RNA polymerase II promoter involved in defense response to fungus|up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi|up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus|up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi|up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus|up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungi|up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungus|up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungi|up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungus|upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungi|upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungus|upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungi|upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungus|upregulation of transcription from RNA polymerase II promoter involved in defence response to fungi|upregulation of transcription from RNA polymerase II promoter involved in defence response to fungus|upregulation of transcription from RNA polymerase II promoter involved in defense response to fungi|upregulation of transcription from RNA polymerase II promoter involved in defense response to fungus True http://purl.obolibrary.org/obo/GO_1901244 GO:1901245 biolink:BiologicalProcess positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization The movement of a B cell receptor (BCR) from the plasma membrane to the inside of the cell, which results in positive regulation of toll-like receptor 9 (TLR9) signaling. For example, internalized BCR signals to recruit TLR9 from multiple small endosomes to large autophagosome-like compartments to enhance TLR9 signaling. go.json BCR-induced TLR9 recruitment|positive regulation of TLR9 signaling pathway by B cell receptor internalization|positive regulation of TLR9 signaling pathway by BCR endocytosis|positive regulation of TLR9 signaling pathway by BCR receptor internalization|positive regulation of toll-like receptor 9 signaling pathway by BCR endocytosis|positive regulation of toll-like receptor 9 signaling pathway by BCR receptor internalization|positive regulation of toll-like receptor 9 signalling pathway by B cell receptor internalization|positive regulation of toll-like receptor 9 signalling pathway by BCR endocytosis|positive regulation of toll-like receptor 9 signalling pathway by BCR receptor internalization http://purl.obolibrary.org/obo/GO_1901245 GO:1901242 biolink:MolecularActivity ABC-type doxorubicin transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out). TC:3.A.1.105.1 go.json ATPase-coupled doxorubicin transmembrane transporter activity|doxorubicin transmembrane-transporting ATPase activity http://purl.obolibrary.org/obo/GO_1901242 GO:0046089 biolink:BiologicalProcess cytosine biosynthetic process The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. go.json cytosine anabolism|cytosine biosynthesis|cytosine formation|cytosine synthesis http://purl.obolibrary.org/obo/GO_0046089 GO:0022030 biolink:BiologicalProcess telencephalon glial cell migration The orderly movement of glial cells through the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0022030 GO:0022031 biolink:BiologicalProcess telencephalon astrocyte cell migration The orderly movement of an astrocyte cell through the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0022031 GO:1901243 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901243 GO:1901251 biolink:BiologicalProcess positive regulation of lung goblet cell differentiation Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation. go.json activation of lung goblet cell differentiation|activation of pulmonary goblet cell differentiation|positive regulation of pulmonary goblet cell differentiation|up regulation of lung goblet cell differentiation|up regulation of pulmonary goblet cell differentiation|up-regulation of lung goblet cell differentiation|up-regulation of pulmonary goblet cell differentiation|upregulation of lung goblet cell differentiation|upregulation of pulmonary goblet cell differentiation http://purl.obolibrary.org/obo/GO_1901251 GO:1901252 biolink:BiologicalProcess regulation of intracellular transport of viral material Any process that modulates the frequency, rate or extent of egress of virus within host cell. go.json regulation of egress of virus within host cell|regulation of movement of virus within host cell|regulation of viral egress http://purl.obolibrary.org/obo/GO_1901252 GO:1901250 biolink:BiologicalProcess negative regulation of lung goblet cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation. go.json down regulation of lung goblet cell differentiation|down regulation of pulmonary goblet cell differentiation|down-regulation of lung goblet cell differentiation|down-regulation of pulmonary goblet cell differentiation|downregulation of lung goblet cell differentiation|downregulation of pulmonary goblet cell differentiation|inhibition of lung goblet cell differentiation|inhibition of pulmonary goblet cell differentiation|negative regulation of pulmonary goblet cell differentiation http://purl.obolibrary.org/obo/GO_1901250 GO:0046090 biolink:BiologicalProcess deoxyadenosine metabolic process The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. go.json deoxyadenosine metabolism http://purl.obolibrary.org/obo/GO_0046090 GO:0046091 biolink:BiologicalProcess deoxyadenosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. go.json deoxyadenosine anabolism|deoxyadenosine biosynthesis|deoxyadenosine formation|deoxyadenosine synthesis http://purl.obolibrary.org/obo/GO_0046091 GO:0071049 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071049 GO:0071047 biolink:BiologicalProcess polyadenylation-dependent mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. go.json poly(A)-dependent mRNA catabolic process http://purl.obolibrary.org/obo/GO_0071047 GO:0071048 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071048 GO:0071045 biolink:BiologicalProcess nuclear histone mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus. go.json http://purl.obolibrary.org/obo/GO_0071045 GO:0071046 biolink:BiologicalProcess nuclear polyadenylation-dependent ncRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA. go.json nuclear poly(A)-dependent ncRNA catabolic process http://purl.obolibrary.org/obo/GO_0071046 GO:0046098 biolink:BiologicalProcess guanine metabolic process The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. go.json guanine metabolism http://purl.obolibrary.org/obo/GO_0046098 GO:0071032 biolink:BiologicalProcess nuclear mRNA surveillance of mRNP export The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm. go.json nuclear mRNA catabolic process of mRNAs in aberrant mRNPs|nuclear mRNA quality control of mRNAs in aberrant mRNPs http://purl.obolibrary.org/obo/GO_0071032 GO:0022021 biolink:BiologicalProcess caudal ganglionic eminence cell proliferation The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0022021 GO:0022022 biolink:BiologicalProcess septal cell proliferation The multiplication or reproduction of septal cells, resulting in the expansion of a cell population. go.json septum cell proliferation http://purl.obolibrary.org/obo/GO_0022022 GO:0071033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071033 GO:0046099 biolink:BiologicalProcess guanine biosynthetic process The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. go.json guanine anabolism|guanine biosynthesis|guanine formation|guanine synthesis http://purl.obolibrary.org/obo/GO_0046099 GO:0071030 biolink:BiologicalProcess nuclear mRNA surveillance of spliceosomal pre-mRNA splicing The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus. go.json nuclear RNA catabolic process of incorrectly spliced pre-mRNA|nuclear mRNA quality control of incorrectly spliced pre-mRNA http://purl.obolibrary.org/obo/GO_0071030 GO:0046096 biolink:BiologicalProcess deoxyuridine metabolic process The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. go.json deoxyuridine metabolism http://purl.obolibrary.org/obo/GO_0046096 GO:0022023 biolink:BiologicalProcess radial glial cell fate commitment in forebrain The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0022023 GO:0022024 biolink:BiologicalProcess obsolete BMP signaling pathway involved in forebrain neuron fate commitment OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. go.json BMP signalling pathway involved in forebrain neuron fate commitment|bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment|bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment True http://purl.obolibrary.org/obo/GO_0022024 GO:0046097 biolink:BiologicalProcess deoxyuridine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. go.json deoxyuridine anabolism|deoxyuridine biosynthesis|deoxyuridine formation|deoxyuridine synthesis http://purl.obolibrary.org/obo/GO_0046097 GO:0071031 biolink:BiologicalProcess nuclear mRNA surveillance of mRNA 3'-end processing The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus. go.json nuclear mRNA catabolic process of mRNA with aberrant 3'-ends|nuclear mRNA quality control of mRNAs with aberrant 3'-ends http://purl.obolibrary.org/obo/GO_0071031 GO:0046094 biolink:BiologicalProcess deoxyinosine metabolic process The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside. go.json deoxyinosine metabolism http://purl.obolibrary.org/obo/GO_0046094 GO:0022025 biolink:BiologicalProcess leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by the binding of leukemia inhibitory factor to its receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. go.json leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment http://purl.obolibrary.org/obo/GO_0022025 GO:0046095 biolink:BiologicalProcess deoxyinosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside. go.json deoxyinosine anabolism|deoxyinosine biosynthesis|deoxyinosine formation|deoxyinosine synthesis http://purl.obolibrary.org/obo/GO_0046095 GO:0022026 biolink:BiologicalProcess epidermal growth factor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. go.json epidermal growth factor signalling pathway involved in forebrain neuron fate commitment http://purl.obolibrary.org/obo/GO_0022026 GO:0046092 biolink:BiologicalProcess deoxycytidine metabolic process The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. go.json deoxycytidine metabolism http://purl.obolibrary.org/obo/GO_0046092 GO:0022027 biolink:BiologicalProcess interkinetic nuclear migration The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle. go.json http://purl.obolibrary.org/obo/GO_0022027 GO:0046093 biolink:BiologicalProcess deoxycytidine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. go.json deoxycytidine anabolism|deoxycytidine biosynthesis|deoxycytidine formation|deoxycytidine synthesis http://purl.obolibrary.org/obo/GO_0046093 GO:0022028 biolink:BiologicalProcess tangential migration from the subventricular zone to the olfactory bulb The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. go.json rostral migratory stream migration http://purl.obolibrary.org/obo/GO_0022028 GO:1901259 biolink:BiologicalProcess chloroplast rRNA processing Any rRNA processing that takes place in chloroplast. go.json http://purl.obolibrary.org/obo/GO_1901259 GO:1901257 biolink:BiologicalProcess negative regulation of macrophage colony-stimulating factor production Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production. go.json down regulation of M-CSF production|down regulation of macrophage colony-stimulating factor production|down-regulation of M-CSF production|down-regulation of macrophage colony-stimulating factor production|downregulation of M-CSF production|downregulation of macrophage colony-stimulating factor production|inhibition of M-CSF production|inhibition of macrophage colony-stimulating factor production|negative regulation of M-CSF production http://purl.obolibrary.org/obo/GO_1901257 GO:1901258 biolink:BiologicalProcess positive regulation of macrophage colony-stimulating factor production Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production. go.json activation of M-CSF production|activation of macrophage colony-stimulating factor production|positive regulation of M-CSF production|up regulation of M-CSF production|up regulation of macrophage colony-stimulating factor production|up-regulation of M-CSF production|up-regulation of macrophage colony-stimulating factor production|upregulation of M-CSF production|upregulation of macrophage colony-stimulating factor production http://purl.obolibrary.org/obo/GO_1901258 GO:1901255 biolink:BiologicalProcess nucleotide-excision repair involved in interstrand cross-link repair Any nucleotide-excision repair that is involved in interstrand cross-link repair. go.json NER involved in ICL repair|NER involved in interstrand cross-link repair|nucleotide-excision repair involved in ICL repair http://purl.obolibrary.org/obo/GO_1901255 GO:1901256 biolink:BiologicalProcess regulation of macrophage colony-stimulating factor production Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production. go.json regulation of M-CSF production http://purl.obolibrary.org/obo/GO_1901256 GO:1901253 biolink:BiologicalProcess negative regulation of intracellular transport of viral material Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material. go.json down regulation of egress of virus within host cell|down regulation of movement of virus within host cell|down regulation of viral egress|down-regulation of egress of virus within host cell|down-regulation of movement of virus within host cell|down-regulation of viral egress|downregulation of egress of virus within host cell|downregulation of movement of virus within host cell|downregulation of viral egress|inhibition of egress of virus within host cell|inhibition of movement of virus within host cell|inhibition of viral egress|negative regulation of egress of virus within host cell|negative regulation of movement of virus within host cell|negative regulation of viral egress http://purl.obolibrary.org/obo/GO_1901253 GO:1901254 biolink:BiologicalProcess positive regulation of intracellular transport of viral material Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material. go.json activation of egress of virus within host cell|activation of movement of virus within host cell|activation of viral egress|positive regulation of egress of virus within host cell|positive regulation of movement of virus within host cell|positive regulation of viral egress|up regulation of egress of virus within host cell|up regulation of movement of virus within host cell|up regulation of viral egress|up-regulation of egress of virus within host cell|up-regulation of movement of virus within host cell|up-regulation of viral egress|upregulation of egress of virus within host cell|upregulation of movement of virus within host cell|upregulation of viral egress http://purl.obolibrary.org/obo/GO_1901254 GO:0022020 biolink:BiologicalProcess medial ganglionic eminence cell proliferation The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0022020 GO:1901262 biolink:BiologicalProcess negative regulation of sorocarp spore cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp spore cell differentiation. go.json down regulation of sorocarp spore cell differentiation|down-regulation of sorocarp spore cell differentiation|downregulation of sorocarp spore cell differentiation|inhibition of sorocarp spore cell differentiation http://purl.obolibrary.org/obo/GO_1901262 GO:1901263 biolink:BiologicalProcess positive regulation of sorocarp spore cell differentiation Any process that activates or increases the frequency, rate or extent of sorocarp spore cell differentiation. go.json activation of sorocarp spore cell differentiation|up regulation of sorocarp spore cell differentiation|up-regulation of sorocarp spore cell differentiation|upregulation of sorocarp spore cell differentiation http://purl.obolibrary.org/obo/GO_1901263 GO:1901260 biolink:BiologicalProcess peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification Any peptidyl-lysine hydroxylation that is involved in bacterial-type EF-P lysine modification. go.json EF-P lysine hydroxylation http://purl.obolibrary.org/obo/GO_1901260 gocheck_do_not_annotate GO:1901261 biolink:BiologicalProcess regulation of sorocarp spore cell differentiation Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1901261 GO:0022029 biolink:BiologicalProcess telencephalon cell migration The orderly movement of a cell from one site to another at least one of which is located in the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0022029 GO:0071038 biolink:BiologicalProcess nuclear polyadenylation-dependent tRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. go.json nuclear poly(A)-dependent tRNA catabolic process http://purl.obolibrary.org/obo/GO_0071038 GO:0071039 biolink:BiologicalProcess nuclear polyadenylation-dependent CUT catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. go.json nuclear poly(A)-dependent CUT catabolic process http://purl.obolibrary.org/obo/GO_0071039 GO:0071036 biolink:BiologicalProcess nuclear polyadenylation-dependent snoRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. go.json nuclear poly(A)-dependent snoRNA catabolic process http://purl.obolibrary.org/obo/GO_0071036 GO:0071037 biolink:BiologicalProcess nuclear polyadenylation-dependent snRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. go.json nuclear poly(A)-dependent snRNA catabolic process http://purl.obolibrary.org/obo/GO_0071037 GO:0071034 biolink:BiologicalProcess CUT catabolic process The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs). go.json cryptic unstable transcript catabolic process http://purl.obolibrary.org/obo/GO_0071034 GO:0071035 biolink:BiologicalProcess nuclear polyadenylation-dependent rRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. go.json nuclear poly(A)-dependent rRNA catabolic process http://purl.obolibrary.org/obo/GO_0071035 GO:0022010 biolink:BiologicalProcess central nervous system myelination The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. go.json myelination in central nervous system http://purl.obolibrary.org/obo/GO_0022010 GO:0071065 biolink:CellularComponent alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1. go.json ITGA9-ITGB1-VCAM1 complex http://purl.obolibrary.org/obo/GO_0071065 GO:0071066 biolink:BiologicalProcess detection of mechanical stimulus involved in sensory perception of wind The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal. go.json detection of mechanical stimulus involved in sensory perception of air flow|detection of wind|perception of wind, detection of mechanical stimulus|perception of wind, sensory detection of mechanical stimulus|perception of wind, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during perception of wind|sensory transduction of mechanical stimulus during perception of wind|sensory transduction of wind http://purl.obolibrary.org/obo/GO_0071066 GO:0022011 biolink:BiologicalProcess myelination in peripheral nervous system The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. go.json peripheral nervous system myelination http://purl.obolibrary.org/obo/GO_0022011 GO:0071063 biolink:BiologicalProcess sensory perception of wind The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal. go.json perception of wind|sensory perception of air flow http://purl.obolibrary.org/obo/GO_0071063 GO:0022012 biolink:BiologicalProcess subpallium cell proliferation in forebrain The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0022012 GO:0071064 biolink:CellularComponent alphaE-beta7 integrin-E-cadherin complex A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin. go.json ITGAE-ITGB7-CDH1 complex http://purl.obolibrary.org/obo/GO_0071064 GO:0022013 biolink:BiologicalProcess pallium cell proliferation in forebrain The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population. go.json http://purl.obolibrary.org/obo/GO_0022013 GO:0071061 biolink:CellularComponent alpha6-beta4 integrin-CD151 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151. go.json ITGA6-ITGB4-CD151 complex http://purl.obolibrary.org/obo/GO_0071061 GO:0022014 biolink:BiologicalProcess obsolete radial glial cell division in subpallium OBSOLETE. The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. go.json True http://purl.obolibrary.org/obo/GO_0022014 GO:0071062 biolink:CellularComponent alphav-beta3 integrin-vitronectin complex A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin. go.json ITGAV-ITGB3-VTN complex http://purl.obolibrary.org/obo/GO_0071062 GO:0022015 biolink:BiologicalProcess radial glial cell division in pallium The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. go.json http://purl.obolibrary.org/obo/GO_0022015 GO:0022016 biolink:BiologicalProcess pallium glioblast division The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells. go.json glioblast cell division in pallium http://purl.obolibrary.org/obo/GO_0022016 GO:0071060 biolink:CellularComponent alpha7-beta1 integrin-CD151 complex A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151. go.json ITGA7-ITGB1-CD151 complex http://purl.obolibrary.org/obo/GO_0071060 GO:0022017 biolink:BiologicalProcess neuroblast division in pallium The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons. go.json http://purl.obolibrary.org/obo/GO_0022017 GO:1901268 biolink:BiologicalProcess cephalosporin C biosynthetic process The chemical reactions and pathways resulting in the formation of cephalosporin C. go.json cephalosporin C anabolism|cephalosporin C biosynthesis|cephalosporin C formation|cephalosporin C synthesis http://purl.obolibrary.org/obo/GO_1901268 GO:1901269 biolink:BiologicalProcess lipooligosaccharide metabolic process The chemical reactions and pathways involving lipooligosaccharide. go.json lipooligosaccharide metabolism http://purl.obolibrary.org/obo/GO_1901269 GO:1901266 biolink:BiologicalProcess cephalosporin C metabolic process The chemical reactions and pathways involving cephalosporin C. go.json cephalosporin C metabolism http://purl.obolibrary.org/obo/GO_1901266 GO:1901267 biolink:BiologicalProcess cephalosporin C catabolic process The chemical reactions and pathways resulting in the breakdown of cephalosporin C. go.json cephalosporin C breakdown|cephalosporin C catabolism|cephalosporin C degradation http://purl.obolibrary.org/obo/GO_1901267 GO:1901264 biolink:BiologicalProcess carbohydrate derivative transport The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901264 GO:1901265 biolink:MolecularActivity nucleoside phosphate binding Binding to nucleoside phosphate. go.json http://purl.obolibrary.org/obo/GO_1901265 GO:1901273 biolink:BiologicalProcess 2-dehydro-3-deoxy-D-gluconic acid catabolic process The chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid. go.json 2-dehydro-3-deoxy-D-gluconic acid breakdown|2-dehydro-3-deoxy-D-gluconic acid catabolism|2-dehydro-3-deoxy-D-gluconic acid degradation http://purl.obolibrary.org/obo/GO_1901273 GO:1901274 biolink:BiologicalProcess 2-dehydro-3-deoxy-D-gluconic acid biosynthetic process The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid. go.json 2-dehydro-3-deoxy-D-gluconic acid anabolism|2-dehydro-3-deoxy-D-gluconic acid biosynthesis|2-dehydro-3-deoxy-D-gluconic acid formation|2-dehydro-3-deoxy-D-gluconic acid synthesis http://purl.obolibrary.org/obo/GO_1901274 GO:1901271 biolink:BiologicalProcess lipooligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipooligosaccharide. go.json lipooligosaccharide anabolism|lipooligosaccharide biosynthesis|lipooligosaccharide formation|lipooligosaccharide synthesis http://purl.obolibrary.org/obo/GO_1901271 GO:1901272 biolink:BiologicalProcess 2-dehydro-3-deoxy-D-gluconic acid metabolic process The chemical reactions and pathways involving 2-dehydro-3-deoxy-D-gluconic acid. go.json 2-dehydro-3-deoxy-D-gluconic acid metabolism http://purl.obolibrary.org/obo/GO_1901272 GO:1901270 biolink:BiologicalProcess lipooligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide. go.json lipooligosaccharide breakdown|lipooligosaccharide catabolism|lipooligosaccharide degradation http://purl.obolibrary.org/obo/GO_1901270 GO:0022018 biolink:BiologicalProcess lateral ganglionic eminence cell proliferation The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population. go.json http://purl.obolibrary.org/obo/GO_0022018 GO:0022019 biolink:BiologicalProcess dorsal lateral ganglionic eminence cell proliferation The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population. go.json http://purl.obolibrary.org/obo/GO_0022019 GO:0071069 biolink:CellularComponent alpha4-beta1 integrin-thrombospondin-1 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1. go.json ITGA4-ITGB1-THBS1 complex http://purl.obolibrary.org/obo/GO_0071069 GO:0071067 biolink:CellularComponent alphav-beta3 integrin-ADAM23 complex A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23. go.json ITGAV-ITGB3-ADAM23 complex http://purl.obolibrary.org/obo/GO_0071067 GO:0071068 biolink:CellularComponent alpha9-beta1 integrin-ADAM12 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12. go.json ITGA9-ITGB1-ADAM12 complex http://purl.obolibrary.org/obo/GO_0071068 GO:0071054 biolink:CellularComponent alpha9-beta1 integrin-ADAM3 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3. go.json ITGA9-ITGB1-ADAM3 complex http://purl.obolibrary.org/obo/GO_0071054 GO:0071055 biolink:CellularComponent alpha9-beta1 integrin-ADAM9 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9. go.json ITGA9-ITGB1-ADAM9 complex http://purl.obolibrary.org/obo/GO_0071055 GO:0022000 biolink:BiologicalProcess forebrain induction by the anterior neural ridge The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate. go.json http://purl.obolibrary.org/obo/GO_0022000 GO:0071052 biolink:CellularComponent alpha9-beta1 integrin-ADAM1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1. go.json ITGA9-ITGB1-ADAM1 complex http://purl.obolibrary.org/obo/GO_0071052 GO:0022001 biolink:BiologicalProcess negative regulation of anterior neural cell fate commitment of the neural plate Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate. go.json caudalization of neural plate|down regulation of anterior neural cell fate of the neural plate|down-regulation of anterior neural cell fate of the neural plate|downregulation of anterior neural cell fate of the neural plate|inhibition of anterior neural cell fate of the neural plate|negative regulation of anterior neural cell fate of the neural plate|posteriorization http://purl.obolibrary.org/obo/GO_0022001 GO:0071053 biolink:CellularComponent alpha9-beta1 integrin-ADAM2 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2. go.json ITGA9-ITGB1-ADAM2 complex http://purl.obolibrary.org/obo/GO_0071053 GO:0022002 biolink:BiologicalProcess negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell. go.json Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate|Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0022002 GO:0022003 biolink:BiologicalProcess negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. go.json fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate|fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate|fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate http://purl.obolibrary.org/obo/GO_0022003 GO:0071050 biolink:BiologicalProcess obsolete sno(s)RNA polyadenylation OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA class molecule (referred to as an sRNA in Archaea). In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation. go.json sRNA polyadenylation|snoRNA polyadenylation True http://purl.obolibrary.org/obo/GO_0071050 GO:0022004 biolink:BiologicalProcess midbrain-hindbrain boundary maturation during brain development A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. go.json http://purl.obolibrary.org/obo/GO_0022004 GO:0071051 biolink:BiologicalProcess polyadenylation-dependent snoRNA 3'-end processing Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. go.json poly(A)-dependent snoRNA 3'-end processing|sno(s)RNA polyadenylation http://purl.obolibrary.org/obo/GO_0071051 GO:0022005 biolink:BiologicalProcess midbrain-hindbrain boundary maturation during neural plate development A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. go.json midbrain-hindbrain boundary maturation involved in neural plate development http://purl.obolibrary.org/obo/GO_0022005 GO:0022006 biolink:BiologicalProcess zona limitans intrathalamica formation The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon. go.json zli biosynthesis|zli formation http://purl.obolibrary.org/obo/GO_0022006 GO:1901279 biolink:BiologicalProcess D-ribose 5-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of D-ribose 5-phosphate. go.json D-ribose 5-phosphate breakdown|D-ribose 5-phosphate catabolism|D-ribose 5-phosphate degradation http://purl.obolibrary.org/obo/GO_1901279 GO:1901277 biolink:BiologicalProcess tartrate biosynthetic process The chemical reactions and pathways resulting in the formation of tartrate. go.json tartrate anabolism|tartrate biosynthesis|tartrate formation|tartrate synthesis http://purl.obolibrary.org/obo/GO_1901277 GO:1901278 biolink:BiologicalProcess D-ribose 5-phosphate metabolic process The chemical reactions and pathways involving D-ribose 5-phosphate. go.json D-ribose 5-phosphate metabolism http://purl.obolibrary.org/obo/GO_1901278 GO:1901275 biolink:BiologicalProcess tartrate metabolic process The chemical reactions and pathways involving tartrate. go.json tartrate metabolism http://purl.obolibrary.org/obo/GO_1901275 GO:1901276 biolink:BiologicalProcess tartrate catabolic process The chemical reactions and pathways resulting in the breakdown of tartrate. go.json tartrate breakdown|tartrate catabolism|tartrate degradation http://purl.obolibrary.org/obo/GO_1901276 GO:1901284 biolink:BiologicalProcess 5,6,7,8-tetrahydromethanopterin catabolic process The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydromethanopterin. go.json 5,6,7,8-tetrahydromethanopterin breakdown|5,6,7,8-tetrahydromethanopterin catabolism|5,6,7,8-tetrahydromethanopterin degradation http://purl.obolibrary.org/obo/GO_1901284 GO:1901285 biolink:BiologicalProcess 5,6,7,8-tetrahydromethanopterin biosynthetic process The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin. go.json 5,6,7,8-tetrahydromethanopterin anabolism|5,6,7,8-tetrahydromethanopterin biosynthesis|5,6,7,8-tetrahydromethanopterin formation|5,6,7,8-tetrahydromethanopterin synthesis http://purl.obolibrary.org/obo/GO_1901285 GO:1901282 biolink:BiologicalProcess fructoselysine biosynthetic process The chemical reactions and pathways resulting in the formation of fructoselysine. go.json fructosyllysine anabolism|fructosyllysine biosynthesis|fructosyllysine biosynthetic process|fructosyllysine formation|fructosyllysine synthesis http://purl.obolibrary.org/obo/GO_1901282 GO:1901283 biolink:BiologicalProcess 5,6,7,8-tetrahydromethanopterin metabolic process The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin. go.json 5,6,7,8-tetrahydromethanopterin metabolism http://purl.obolibrary.org/obo/GO_1901283 GO:1901280 biolink:BiologicalProcess D-ribose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of D-ribose 5-phosphate. go.json D-ribose 5-phosphate anabolism|D-ribose 5-phosphate biosynthesis|D-ribose 5-phosphate formation|D-ribose 5-phosphate synthesis http://purl.obolibrary.org/obo/GO_1901280 GO:1901281 biolink:BiologicalProcess fructoselysine catabolic process The chemical reactions and pathways resulting in the breakdown of fructoselysine. go.json fructosyllysine breakdown|fructosyllysine catabolic process|fructosyllysine catabolism|fructosyllysine degradation http://purl.obolibrary.org/obo/GO_1901281 GO:0022007 biolink:BiologicalProcess convergent extension involved in neural plate elongation The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate. go.json http://purl.obolibrary.org/obo/GO_0022007 GO:0022008 biolink:BiologicalProcess neurogenesis Generation of cells within the nervous system. Wikipedia:Neurogenesis go.json nervous system cell generation|neural cell differentiation http://purl.obolibrary.org/obo/GO_0022008 GO:0022009 biolink:BiologicalProcess central nervous system vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. go.json http://purl.obolibrary.org/obo/GO_0022009 GO:0071058 biolink:CellularComponent alpha3-beta1 integrin-CD151 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151. go.json ITGA3-ITGB1-CD151 complex http://purl.obolibrary.org/obo/GO_0071058 GO:0071059 biolink:CellularComponent alpha6-beta1 integrin-CD151 complex A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151. go.json ITGA6-ITGB1-CD151 complex http://purl.obolibrary.org/obo/GO_0071059 GO:0071056 biolink:CellularComponent alpha9-beta1 integrin-ADAM15 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15. go.json ITGA9-ITGB1-ADAM15 complex http://purl.obolibrary.org/obo/GO_0071056 GO:0071057 biolink:CellularComponent alphav-beta3 integrin-ADAM15 complex A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15. go.json ITGAV-ITGB3-ADAM15 complex http://purl.obolibrary.org/obo/GO_0071057 GO:0061600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061600 GO:0061601 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061601 GO:0061602 biolink:MolecularActivity molybdenum cofactor cytidylyltransferase activity Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor. EC:2.7.7.76|RHEA:31335 go.json http://purl.obolibrary.org/obo/GO_0061602 GO:0061603 biolink:MolecularActivity molybdenum cofactor guanylyltransferase activity Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor. EC:2.7.7.77|RHEA:34243 go.json http://purl.obolibrary.org/obo/GO_0061603 GO:0061604 biolink:MolecularActivity molybdopterin-synthase sulfurtransferase activity Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase. EC:2.8.1.11|RHEA:48612 go.json http://purl.obolibrary.org/obo/GO_0061604 GO:0061605 biolink:MolecularActivity molybdopterin-synthase adenylyltransferase activity Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP. EC:2.7.7.80|RHEA:43616 go.json http://purl.obolibrary.org/obo/GO_0061605 GO:0061606 biolink:BiologicalProcess N-terminal protein amino acid propionylation The propionylation of the N-terminal amino acid of proteins. go.json http://purl.obolibrary.org/obo/GO_0061606 gocheck_do_not_annotate GO:0061607 biolink:MolecularActivity peptide alpha-N-propionyltransferase activity Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein. go.json N-terminal propionyltransferase activity http://purl.obolibrary.org/obo/GO_0061607 GO:0061608 biolink:MolecularActivity nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. go.json importin activity http://purl.obolibrary.org/obo/GO_0061608 GO:0061609 biolink:MolecularActivity fructose-1-phosphate aldolase activity Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde. RHEA:30851|Reactome:R-HSA-5656438|Reactome:R-HSA-70342 go.json http://purl.obolibrary.org/obo/GO_0061609 GO:0061620 biolink:BiologicalProcess glycolytic process through glucose-6-phosphate The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP. MetaCyc:GLYCOLYSIS go.json http://purl.obolibrary.org/obo/GO_0061620 GO:0061621 biolink:BiologicalProcess canonical glycolysis The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. MetaCyc:ANAGLYCOLYSIS-PWY|Reactome:R-HSA-70171|Wikipedia:Glycolysis go.json http://purl.obolibrary.org/obo/GO_0061621 GO:0061622 biolink:BiologicalProcess glycolytic process through glucose-1-phosphate The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. go.json http://purl.obolibrary.org/obo/GO_0061622 GO:0061623 biolink:BiologicalProcess glycolytic process from galactose The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP. go.json http://purl.obolibrary.org/obo/GO_0061623 GO:0061624 biolink:BiologicalProcess fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. go.json http://purl.obolibrary.org/obo/GO_0061624 GO:0061625 biolink:BiologicalProcess glycolytic process through fructose-1-phosphate The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH. go.json http://purl.obolibrary.org/obo/GO_0061625 GO:0061626 biolink:BiologicalProcess pharyngeal arch artery morphogenesis The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. go.json aortic arch artery morphogenesis http://purl.obolibrary.org/obo/GO_0061626 GO:0061627 biolink:MolecularActivity S-methylmethionine-homocysteine S-methyltransferase activity Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+. EC:2.1.1.10|MetaCyc:MMUM-RXN|RHEA:26337|Reactome:R-HSA-5696838 go.json S-methylmethionine homocysteine transmethylase activity|homocysteine methyltransferase activity|homocysteine transmethylase activity|methylmethionine:homocysteine methyltransferase activity http://purl.obolibrary.org/obo/GO_0061627 GO:0061628 biolink:MolecularActivity H3K27me3 modified histone binding Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation. go.json H3-K27me3 modified histone binding http://purl.obolibrary.org/obo/GO_0061628 GO:0061629 biolink:MolecularActivity RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. go.json RNA polymerase II activating transcription factor binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II sequence-specific DNA binding transcription factor binding|RNA polymerase II sequence-specific DNA-binding transcription factor binding|RNA polymerase II transcription factor binding http://purl.obolibrary.org/obo/GO_0061629 GO:0061610 biolink:BiologicalProcess glycerol to glycerone phosphate metabolic process The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate. go.json glycerol metabolism to DHAP|glycerol metabolism to dihydroxyacetone phosphate|glycerol metabolism to glycerone phosphate|glycerol to DHAP metabolic process|glycerol to dihydroxyacetone phosphate metabolic process http://purl.obolibrary.org/obo/GO_0061610 GO:0061611 biolink:BiologicalProcess mannose to fructose-6-phosphate metabolic process The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate. go.json mannose metabolism to fructose-6-phosphate http://purl.obolibrary.org/obo/GO_0061611 GO:0061612 biolink:BiologicalProcess galactose to glucose-1-phosphate metabolic process The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate. go.json http://purl.obolibrary.org/obo/GO_0061612 GO:0061613 biolink:BiologicalProcess glycolytic process from glycerol The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH. go.json http://purl.obolibrary.org/obo/GO_0061613 GO:0061614 biolink:BiologicalProcess miRNA transcription The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation. go.json miRNA gene transcription|microRNA gene transcription|pri-miRNA transcription by RNA polymerase II|pri-miRNA transcription from RNA polymerase II promoter|primary miRNA gene transcription http://purl.obolibrary.org/obo/GO_0061614 GO:0061615 biolink:BiologicalProcess glycolytic process through fructose-6-phosphate The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. MetaCyc:PWY-5484 go.json glycolysis through fructose-6-phosphate http://purl.obolibrary.org/obo/GO_0061615 GO:0061616 biolink:BiologicalProcess glycolytic process from fructose through fructose-6-phosphate The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate. MetaCyc:PWY-5484 go.json glycolysis from fructose through fructose-6-phosphate http://purl.obolibrary.org/obo/GO_0061616 GO:0061617 biolink:CellularComponent MICOS complex Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60. go.json Fcj1 complex|MINOS complex|MitOS complex|mitochondrial contact site and cristae organizing system http://purl.obolibrary.org/obo/GO_0061617 GO:0061618 biolink:CellularComponent obsolete sublamina densa OBSOLETE. The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers. go.json True http://purl.obolibrary.org/obo/GO_0061618 GO:0061619 biolink:BiologicalProcess glycolytic process from mannose through fructose-6-phosphate The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. go.json http://purl.obolibrary.org/obo/GO_0061619 GO:0046000 biolink:BiologicalProcess positive regulation of ecdysteroid secretion Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid. go.json activation of ecdysteroid secretion|stimulation of ecdysteroid secretion|up regulation of ecdysteroid secretion|up-regulation of ecdysteroid secretion|upregulation of ecdysteroid secretion http://purl.obolibrary.org/obo/GO_0046000 GO:0046007 biolink:BiologicalProcess negative regulation of activated T cell proliferation Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. go.json down regulation of activated T cell proliferation|down-regulation of activated T cell proliferation|downregulation of activated T cell proliferation|inhibition of activated T cell proliferation|negative regulation of activated T lymphocyte proliferation|negative regulation of activated T-cell proliferation|negative regulation of activated T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046007 GO:0046008 biolink:BiologicalProcess regulation of female receptivity, post-mating Any process that modulates the receptiveness of a female to male advances subsequent to mating. go.json http://purl.obolibrary.org/obo/GO_0046008 GO:0046005 biolink:BiologicalProcess positive regulation of circadian sleep/wake cycle, REM sleep Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep. go.json activation of circadian sleep/wake cycle, REM sleep|positive regulation of REM sleep|stimulation of circadian sleep/wake cycle, REM sleep|up regulation of circadian sleep/wake cycle, REM sleep|up-regulation of circadian sleep/wake cycle, REM sleep|upregulation of circadian sleep/wake cycle, REM sleep http://purl.obolibrary.org/obo/GO_0046005 GO:0046006 biolink:BiologicalProcess regulation of activated T cell proliferation Any process that modulates the frequency, rate or extent of activated T cell proliferation. go.json regulation of activated T lymphocyte proliferation|regulation of activated T-cell proliferation|regulation of activated T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046006 GO:0046003 biolink:BiologicalProcess negative regulation of syncytial blastoderm mitotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle. go.json down regulation of progression through syncytial blastoderm mitotic cell cycle|down-regulation of progression through syncytial blastoderm mitotic cell cycle|downregulation of progression through syncytial blastoderm mitotic cell cycle|inhibition of progression through syncytial blastoderm mitotic cell cycle|negative regulation of progression through syncytial blastoderm mitotic cell cycle|negative regulation of syncytial blastoderm cell cycle progression http://purl.obolibrary.org/obo/GO_0046003 GO:0046004 biolink:BiologicalProcess positive regulation of syncytial blastoderm mitotic cell cycle Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle. go.json activation of progression through syncytial blastoderm mitotic cell cycle|positive regulation of progression through syncytial blastoderm mitotic cell cycle|positive regulation of syncytial blastoderm cell cycle progression|stimulation of progression through syncytial blastoderm mitotic cell cycle|up regulation of progression through syncytial blastoderm mitotic cell cycle|up-regulation of progression through syncytial blastoderm mitotic cell cycle|upregulation of progression through syncytial blastoderm mitotic cell cycle http://purl.obolibrary.org/obo/GO_0046004 GO:0046001 biolink:BiologicalProcess negative regulation of preblastoderm mitotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle. go.json down regulation of progression through preblastoderm mitotic cell cycle|down-regulation of progression through preblastoderm mitotic cell cycle|downregulation of progression through preblastoderm mitotic cell cycle|inhibition of progression through preblastoderm mitotic cell cycle|negative regulation of preblastoderm mitotic cell cycle progression|negative regulation of progression through preblastoderm mitotic cell cycle http://purl.obolibrary.org/obo/GO_0046001 GO:0046002 biolink:BiologicalProcess positive regulation of preblastoderm mitotic cell cycle Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle. go.json activation of progression through preblastoderm mitotic cell cycle|positive regulation of preblastoderm mitotic cell cycle progression|positive regulation of progression through preblastoderm mitotic cell cycle|stimulation of progression through preblastoderm mitotic cell cycle|up regulation of progression through preblastoderm mitotic cell cycle|up-regulation of progression through preblastoderm mitotic cell cycle|upregulation of progression through preblastoderm mitotic cell cycle http://purl.obolibrary.org/obo/GO_0046002 GO:0061640 biolink:BiologicalProcess cytoskeleton-dependent cytokinesis A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0061640 GO:0061641 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061641 GO:0061642 biolink:BiologicalProcess chemoattraction of axon The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal. go.json http://purl.obolibrary.org/obo/GO_0061642 GO:0061643 biolink:BiologicalProcess chemorepulsion of axon The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. go.json http://purl.obolibrary.org/obo/GO_0061643 GO:0061644 biolink:BiologicalProcess protein localization to CENP-A containing chromatin Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin. go.json http://purl.obolibrary.org/obo/GO_0061644 GO:0061645 biolink:CellularComponent endocytic patch The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0061645 GO:0061646 biolink:BiologicalProcess positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0061646 GO:0046009 biolink:BiologicalProcess positive regulation of female receptivity, post-mating Any process that increases the receptiveness of a female to male advances subsequent to mating. go.json activation of female receptivity, post-mating|stimulation of female receptivity, post-mating|up regulation of female receptivity, post-mating|up-regulation of female receptivity, post-mating|upregulation of female receptivity, post-mating http://purl.obolibrary.org/obo/GO_0046009 GO:0061647 biolink:BiologicalProcess histone H3-K9 modification The modification of histone H3 at a lysine in position 9 of the histone. go.json http://purl.obolibrary.org/obo/GO_0061647 gocheck_do_not_annotate GO:0061648 biolink:BiologicalProcess tooth replacement The process whose specific outcome is the replacement of an existing tooth with another tooth. go.json http://purl.obolibrary.org/obo/GO_0061648 GO:0061649 biolink:MolecularActivity ubiquitin modification-dependent histone binding Binding to a histone protein in which a residue has been modified by ubiquitination. go.json ubiquitinated histone binding http://purl.obolibrary.org/obo/GO_0061649 GO:0046010 biolink:BiologicalProcess positive regulation of circadian sleep/wake cycle, non-REM sleep Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. go.json activation of circadian sleep/wake cycle, non-REM sleep|positive regulation of non-REM sleep|stimulation of circadian sleep/wake cycle, non-REM sleep|up regulation of circadian sleep/wake cycle, non-REM sleep|up-regulation of circadian sleep/wake cycle, non-REM sleep|upregulation of circadian sleep/wake cycle, non-REM sleep http://purl.obolibrary.org/obo/GO_0046010 GO:0046011 biolink:BiologicalProcess regulation of oskar mRNA translation Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex. go.json http://purl.obolibrary.org/obo/GO_0046011 GO:0046018 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle. go.json activation of transcription from RNA polymerase I promoter during mitosis|mitotic activation of transcription from Pol I promoter|positive regulation of transcription from Pol I promoter during mitosis|positive regulation of transcription from RNA polymerase I promoter, mitotic|stimulation of transcription from RNA polymerase I promoter during mitosis|up regulation of transcription from RNA polymerase I promoter during mitosis|up-regulation of transcription from RNA polymerase I promoter during mitosis|upregulation of transcription from RNA polymerase I promoter during mitosis True http://purl.obolibrary.org/obo/GO_0046018 GO:0046019 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter by pheromones OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter. go.json regulation of transcription from Pol II promoter by pheromones True http://purl.obolibrary.org/obo/GO_0046019 GO:0046016 biolink:BiologicalProcess positive regulation of transcription by glucose Any process involving glucose that activates or increases the rate of transcription. go.json activation of transcription by glucose|stimulation of transcription by glucose|up regulation of transcription by glucose|up-regulation of transcription by glucose|upregulation of transcription by glucose http://purl.obolibrary.org/obo/GO_0046016 GO:0046017 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle. go.json mitotic regulation of transcription from Pol I promoter|regulation of transcription from Pol I promoter during mitosis|regulation of transcription from RNA polymerase I promoter during mitosis True http://purl.obolibrary.org/obo/GO_0046017 GO:0046014 biolink:BiologicalProcess negative regulation of T cell homeostatic proliferation Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. go.json down regulation of T cell homeostatic proliferation|down-regulation of T cell homeostatic proliferation|downregulation of T cell homeostatic proliferation|inhibition of T cell homeostatic proliferation|negative regulation of T lymphocyte homeostatic proliferation|negative regulation of T-cell homeostatic proliferation|negative regulation of T-lymphocyte homeostatic proliferation|negative regulation of resting T cell proliferation http://purl.obolibrary.org/obo/GO_0046014 GO:0046015 biolink:BiologicalProcess regulation of transcription by glucose Any process involving glucose that modulates the frequency, rate or extent or transcription. go.json http://purl.obolibrary.org/obo/GO_0046015 GO:0046012 biolink:BiologicalProcess positive regulation of oskar mRNA translation Any process that activates or increases the frequency, rate or extent of oskar mRNA translation. go.json activation of oskar mRNA translation|stimulation of oskar mRNA translation|up regulation of oskar mRNA translation|up-regulation of oskar mRNA translation|upregulation of oskar mRNA translation http://purl.obolibrary.org/obo/GO_0046012 GO:0046013 biolink:BiologicalProcess regulation of T cell homeostatic proliferation Any process that modulates the frequency, rate or extent of resting T cell proliferation. go.json regulation of T lymphocyte homeostatic proliferation|regulation of T-cell homeostatic proliferation|regulation of T-lymphocyte homeostatic proliferation|regulation of resting T cell proliferation http://purl.obolibrary.org/obo/GO_0046013 GO:0061630 biolink:MolecularActivity ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. Reactome:R-HSA-1225956|Reactome:R-HSA-1504190|Reactome:R-HSA-201445|Reactome:R-HSA-3322429|Reactome:R-HSA-3640861|Reactome:R-HSA-4608852|Reactome:R-HSA-4641129|Reactome:R-HSA-4641159|Reactome:R-HSA-4641246|Reactome:R-HSA-4641253|Reactome:R-HSA-5246693|Reactome:R-HSA-5610737|Reactome:R-HSA-5632648|Reactome:R-HSA-5635856|Reactome:R-HSA-5635864|Reactome:R-HSA-5654672|Reactome:R-HSA-5654677|Reactome:R-HSA-5654679|Reactome:R-HSA-5654684|Reactome:R-HSA-5658424|Reactome:R-HSA-5674022|Reactome:R-HSA-5682858|Reactome:R-HSA-5684071|Reactome:R-HSA-5687081|Reactome:R-HSA-5689111|Reactome:R-HSA-5690827|Reactome:R-HSA-6781867|Reactome:R-HSA-6782943|Reactome:R-HSA-6785361|Reactome:R-HSA-6790487|Reactome:R-HSA-6798373|Reactome:R-HSA-6804253|Reactome:R-HSA-6804441|Reactome:R-HSA-6804724|Reactome:R-HSA-6804879|Reactome:R-HSA-6804942|Reactome:R-HSA-6807106|Reactome:R-HSA-6807134|Reactome:R-HSA-68946|Reactome:R-HSA-69015|Reactome:R-HSA-8848829|Reactome:R-HSA-8851011|Reactome:R-HSA-8854041|Reactome:R-HSA-8854051|Reactome:R-HSA-8854628|Reactome:R-HSA-8866546|Reactome:R-HSA-8866856|Reactome:R-HSA-8867288|Reactome:R-HSA-8875183|Reactome:R-HSA-8875431|Reactome:R-HSA-8876258|Reactome:R-HSA-8877003|Reactome:R-HSA-8938773|Reactome:R-HSA-8938815|Reactome:R-HSA-8939335|Reactome:R-HSA-8939706|Reactome:R-HSA-8942101|Reactome:R-HSA-8943003|Reactome:R-HSA-8943040|Reactome:R-HSA-8943080|Reactome:R-HSA-8948775|Reactome:R-HSA-8948832|Reactome:R-HSA-8952382|Reactome:R-HSA-8952419|Reactome:R-HSA-8953946|Reactome:R-HSA-8956026|Reactome:R-HSA-8956684|Reactome:R-HSA-9008076|Reactome:R-HSA-9008479|Reactome:R-HSA-9009308|Reactome:R-HSA-9009403|Reactome:R-HSA-9011300|Reactome:R-HSA-9021523|Reactome:R-HSA-9033485|Reactome:R-HSA-934604|Reactome:R-HSA-936462|Reactome:R-HSA-936475|Reactome:R-HSA-9604629|Reactome:R-HSA-9685195|Reactome:R-HSA-9686920|Reactome:R-HSA-9686969|Reactome:R-HSA-9705738|Reactome:R-HSA-9706354|Reactome:R-HSA-9706356|Reactome:R-HSA-9708517|Reactome:R-HSA-9733316|Reactome:R-HSA-9755304|Reactome:R-HSA-9755505|Reactome:R-HSA-9759154|Reactome:R-HSA-9759172|Reactome:R-HSA-9762091|Reactome:R-HSA-9766645|Reactome:R-HSA-990526 go.json E3|ER-associated E3 ligase|protein ubiquitination activity|ubiquitin ligase activity http://purl.obolibrary.org/obo/GO_0061630 GO:0061631 biolink:MolecularActivity ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. EC:2.3.2.23 go.json E2|HECT E3 http://purl.obolibrary.org/obo/GO_0061631 GO:0061632 biolink:MolecularActivity RNA lariat debranching enzyme activator activity Binds to and increases the activity of an RNA lariat debranching enzyme. go.json http://purl.obolibrary.org/obo/GO_0061632 GO:0061633 biolink:BiologicalProcess transport-coupled glycolytic process through glucose-6-phosphate The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport. go.json http://purl.obolibrary.org/obo/GO_0061633 GO:0061634 biolink:MolecularActivity alpha-D-xyloside xylohydrolase Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose. EC:3.2.1.177 go.json alpha-xylosidase http://purl.obolibrary.org/obo/GO_0061634 GO:0061635 biolink:BiologicalProcess regulation of protein complex stability Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly. go.json http://purl.obolibrary.org/obo/GO_0061635 GO:0061636 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061636 GO:0061637 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061637 GO:0061638 biolink:CellularComponent CENP-A containing chromatin The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment. go.json centromeric core domain chromatin|centromeric core region chromatin|chromatin containing CENP-A|nuclear CENP-A containing chromatin http://purl.obolibrary.org/obo/GO_0061638 GO:0061639 biolink:BiologicalProcess Cdv-dependent cytokinesis A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells. go.json http://purl.obolibrary.org/obo/GO_0061639 GO:0046021 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle. go.json mitotic regulation of transcription from Pol II promoter|regulation of transcription from Pol II promoter, mitotic|regulation of transcription from RNA polymerase II promoter during mitosis True http://purl.obolibrary.org/obo/GO_0046021 GO:0046022 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle. go.json activation of transcription from RNA polymerase II promoter during mitosis|mitotic activation of transcription from Pol II promoter|positive regulation of transcription from Pol II promoter during mitosis|positive regulation of transcription from RNA polymerase II promoter, mitotic|stimulation of transcription from RNA polymerase II promoter during mitosis|up regulation of transcription from RNA polymerase II promoter during mitosis|up-regulation of transcription from RNA polymerase II promoter during mitosis|upregulation of transcription from RNA polymerase II promoter during mitosis True http://purl.obolibrary.org/obo/GO_0046022 GO:0046020 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter by pheromones OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. go.json down regulation of transcription from RNA polymerase II promoter by pheromones|down-regulation of transcription from RNA polymerase II promoter by pheromones|downregulation of transcription from RNA polymerase II promoter by pheromones|inhibition of transcription from RNA polymerase II promoter by pheromones|negative regulation of transcription from Pol II promoter by pheromones True http://purl.obolibrary.org/obo/GO_0046020 GO:0046029 biolink:MolecularActivity mannitol dehydrogenase activity Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + H+ + NADH. EC:1.1.1.255|KEGG_REACTION:R07135|MetaCyc:1.1.1.255-RXN|RHEA:15029 go.json MTD activity|NAD-dependent mannitol dehydrogenase activity|mannitol:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0046029 GO:0046027 biolink:MolecularActivity phospholipid:diacylglycerol acyltransferase activity Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol. EC:2.3.1.158|MetaCyc:2.3.1.158-RXN|RHEA:14057 go.json PDAT activity|phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0046027 GO:0046028 biolink:MolecularActivity electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II. go.json plastocyanin http://purl.obolibrary.org/obo/GO_0046028 GO:0046025 biolink:MolecularActivity precorrin-6Y C5,15-methyltransferase (decarboxylating) activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2. EC:2.1.1.132|MetaCyc:2.1.1.132-RXN|RHEA:17477 go.json S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)|precorrin-6 methyltransferase activity|precorrin-6Y methylase activity http://purl.obolibrary.org/obo/GO_0046025 GO:0046026 biolink:MolecularActivity precorrin-4 C11-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. EC:2.1.1.133|MetaCyc:2.1.1.133-RXN|RHEA:22012 go.json CobM|S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity http://purl.obolibrary.org/obo/GO_0046026 GO:0046023 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle. go.json mitotic regulation of transcription from Pol III promoter|regulation of transcription from Pol III promoter, mitotic|regulation of transcription from RNA polymerase III promoter during mitosis True http://purl.obolibrary.org/obo/GO_0046023 GO:0061660 biolink:MolecularActivity Atg12 ligase activity Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061660 GO:0046024 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III that occurs during the mitotic cell cycle. go.json activation of transcription from RNA polymerase III promoter during mitosis|mitotic activation of transcription from Pol III promoter|positive regulation of transcription from Pol III promoter during mitosis|positive regulation of transcription from RNA polymerase III promoter, mitotic|stimulation of transcription from RNA polymerase III promoter during mitosis|up regulation of transcription from RNA polymerase III promoter during mitosis|up-regulation of transcription from RNA polymerase III promoter during mitosis|upregulation of transcription from RNA polymerase III promoter during mitosis True http://purl.obolibrary.org/obo/GO_0046024 GO:0061661 biolink:MolecularActivity FAT10 ligase activity Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S = X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061661 GO:0061662 biolink:MolecularActivity ISG15 ligase activity Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061662 GO:0061663 biolink:MolecularActivity NEDD8 ligase activity Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061663 GO:0061664 biolink:MolecularActivity Pup ligase activity Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061664 GO:0061665 biolink:MolecularActivity SUMO ligase activity Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. Reactome:R-HSA-9834809 go.json E3 http://purl.obolibrary.org/obo/GO_0061665 GO:0061666 biolink:MolecularActivity UFM1 ligase activity Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061666 GO:0061667 biolink:MolecularActivity URM1 ligase activity Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate. go.json E3 http://purl.obolibrary.org/obo/GO_0061667 GO:0061668 biolink:BiologicalProcess mitochondrial ribosome assembly The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits. go.json http://purl.obolibrary.org/obo/GO_0061668 GO:0061669 biolink:BiologicalProcess spontaneous neurotransmitter secretion Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential. go.json stimulus-independent neurotransmitter secretion http://purl.obolibrary.org/obo/GO_0061669 GO:0046032 biolink:BiologicalProcess ADP catabolic process The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate. go.json ADP breakdown|ADP catabolism|ADP degradation http://purl.obolibrary.org/obo/GO_0046032 GO:0046033 biolink:BiologicalProcess AMP metabolic process The chemical reactions and pathways involving AMP, adenosine monophosphate. go.json AMP metabolism|adenylate forming enzyme activity http://purl.obolibrary.org/obo/GO_0046033 GO:0046030 biolink:MolecularActivity inositol trisphosphate phosphatase activity Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. go.json IP(3) phosphatase activity|IP3 phosphatase activity http://purl.obolibrary.org/obo/GO_0046030 GO:0046031 biolink:BiologicalProcess ADP metabolic process The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. go.json ADP metabolism http://purl.obolibrary.org/obo/GO_0046031 GO:0046038 biolink:BiologicalProcess GMP catabolic process The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate. go.json GMP breakdown|GMP catabolism|GMP degradation http://purl.obolibrary.org/obo/GO_0046038 GO:0046039 biolink:BiologicalProcess GTP metabolic process The chemical reactions and pathways involving GTP, guanosine triphosphate. go.json GTP metabolism http://purl.obolibrary.org/obo/GO_0046039 GO:0046036 biolink:BiologicalProcess CTP metabolic process The chemical reactions and pathways involving CTP, cytidine triphosphate. go.json CTP deamination|CTP metabolism http://purl.obolibrary.org/obo/GO_0046036 GO:0046037 biolink:BiologicalProcess GMP metabolic process The chemical reactions and pathways involving GMP, guanosine monophosphate. go.json GMP metabolism http://purl.obolibrary.org/obo/GO_0046037 GO:0046034 biolink:BiologicalProcess ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. go.json ATP metabolism http://purl.obolibrary.org/obo/GO_0046034 GO:0061650 biolink:MolecularActivity ubiquitin-like protein conjugating enzyme activity Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. go.json E2|small conjugating protein conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0061650 GO:0046035 biolink:BiologicalProcess CMP metabolic process The chemical reactions and pathways involving CMP, cytidine monophosphate. go.json CMP metabolism http://purl.obolibrary.org/obo/GO_0046035 GO:0061651 biolink:MolecularActivity Atg12 conjugating enzyme activity Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061651 GO:0061652 biolink:MolecularActivity FAT10 conjugating enzyme activity Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061652 GO:0061653 biolink:MolecularActivity ISG15 conjugating enzyme activity Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061653 GO:0061654 biolink:MolecularActivity NEDD8 conjugating enzyme activity Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue. EC:2.3.2.34 go.json E2 http://purl.obolibrary.org/obo/GO_0061654 GO:0061655 biolink:MolecularActivity Pup conjugating enzyme activity Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061655 GO:0061656 biolink:MolecularActivity SUMO conjugating enzyme activity Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061656 GO:0061657 biolink:MolecularActivity UFM1 conjugating enzyme activity Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061657 GO:0061658 biolink:MolecularActivity URM1 conjugating enzyme activity Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue. go.json E2 http://purl.obolibrary.org/obo/GO_0061658 GO:0061659 biolink:MolecularActivity ubiquitin-like protein ligase activity Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. go.json E3|small conjugating protein ligase activity http://purl.obolibrary.org/obo/GO_0061659 GO:1905130 biolink:BiologicalProcess carcinine import across plasma membrane The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_1905130 GO:1905131 biolink:MolecularActivity carcinine transmembrane transporter activity Enables the transfer of carcinine from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1905131 GO:1905132 biolink:BiologicalProcess regulation of meiotic chromosome separation Any process that modulates the frequency, rate or extent of meiotic chromosome separation. go.json regulation of chromosome separation during meiosis|regulation of meiotic chromosome resolution http://purl.obolibrary.org/obo/GO_1905132 GO:1905133 biolink:BiologicalProcess negative regulation of meiotic chromosome separation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation. go.json down regulation of chromosome separation during meiosis|down regulation of meiotic chromosome resolution|down regulation of meiotic chromosome separation|down-regulation of chromosome separation during meiosis|down-regulation of meiotic chromosome resolution|down-regulation of meiotic chromosome separation|downregulation of chromosome separation during meiosis|downregulation of meiotic chromosome resolution|downregulation of meiotic chromosome separation|inhibition of chromosome separation during meiosis|inhibition of meiotic chromosome resolution|inhibition of meiotic chromosome separation|negative regulation of chromosome separation during meiosis|negative regulation of meiotic chromosome resolution http://purl.obolibrary.org/obo/GO_1905133 GO:1905134 biolink:BiologicalProcess positive regulation of meiotic chromosome separation Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation. go.json activation of chromosome separation during meiosis|activation of meiotic chromosome resolution|activation of meiotic chromosome separation|positive regulation of chromosome separation during meiosis|positive regulation of meiotic chromosome resolution|up regulation of chromosome separation during meiosis|up regulation of meiotic chromosome resolution|up regulation of meiotic chromosome separation|up-regulation of chromosome separation during meiosis|up-regulation of meiotic chromosome resolution|up-regulation of meiotic chromosome separation|upregulation of chromosome separation during meiosis|upregulation of meiotic chromosome resolution|upregulation of meiotic chromosome separation http://purl.obolibrary.org/obo/GO_1905134 GO:1905135 biolink:BiologicalProcess biotin import across plasma membrane The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol. go.json biotin import|biotin import into cell http://purl.obolibrary.org/obo/GO_1905135 GO:1905125 biolink:BiologicalProcess positive regulation of glucosylceramidase activity Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity. go.json activation of D-glucosyl-N-acylsphingosine glucohydrolase activity|activation of GlcCer-beta-glucosidase activity|activation of acid beta-glucosidase activity|activation of beta-D-glucocerebrosidase activity|activation of beta-glucocerebrosidase activity|activation of beta-glucosylceramidase activity|activation of ceramide glucosidase activity|activation of glucocerebrosidase activity|activation of glucosphingosine glucosylhydrolase activity|activation of glucosylceramidase activity|activation of glucosylcerebrosidase activity|activation of glucosylsphingosine beta-D-glucosidase activity|activation of glucosylsphingosine beta-glucosidase activity|activation of psychosine hydrolase activity|positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|positive regulation of GCase activity|positive regulation of GlcCer-beta-glucosidase activity|positive regulation of acid beta-glucosidase activity|positive regulation of beta-D-glucocerebrosidase activity|positive regulation of beta-glucocerebrosidase activity|positive regulation of beta-glucosylceramidase activity|positive regulation of ceramide glucosidase activity|positive regulation of glucocerebrosidase activity|positive regulation of glucosphingosine glucosylhydrolase activity|positive regulation of glucosylcerebrosidase activity|positive regulation of glucosylsphingosine beta-D-glucosidase activity|positive regulation of glucosylsphingosine beta-glucosidase activity|positive regulation of psychosine hydrolase activity|up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|up regulation of GlcCer-beta-glucosidase activity|up regulation of acid beta-glucosidase activity|up regulation of beta-D-glucocerebrosidase activity|up regulation of beta-glucocerebrosidase activity|up regulation of beta-glucosylceramidase activity|up regulation of ceramide glucosidase activity|up regulation of glucocerebrosidase activity|up regulation of glucosphingosine glucosylhydrolase activity|up regulation of glucosylceramidase activity|up regulation of glucosylcerebrosidase activity|up regulation of glucosylsphingosine beta-D-glucosidase activity|up regulation of glucosylsphingosine beta-glucosidase activity|up regulation of psychosine hydrolase activity|up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|up-regulation of GlcCer-beta-glucosidase activity|up-regulation of acid beta-glucosidase activity|up-regulation of beta-D-glucocerebrosidase activity|up-regulation of beta-glucocerebrosidase activity|up-regulation of beta-glucosylceramidase activity|up-regulation of ceramide glucosidase activity|up-regulation of glucocerebrosidase activity|up-regulation of glucosphingosine glucosylhydrolase activity|up-regulation of glucosylceramidase activity|up-regulation of glucosylcerebrosidase activity|up-regulation of glucosylsphingosine beta-D-glucosidase activity|up-regulation of glucosylsphingosine beta-glucosidase activity|up-regulation of psychosine hydrolase activity|upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|upregulation of GlcCer-beta-glucosidase activity|upregulation of acid beta-glucosidase activity|upregulation of beta-D-glucocerebrosidase activity|upregulation of beta-glucocerebrosidase activity|upregulation of beta-glucosylceramidase activity|upregulation of ceramide glucosidase activity|upregulation of glucocerebrosidase activity|upregulation of glucosphingosine glucosylhydrolase activity|upregulation of glucosylceramidase activity|upregulation of glucosylcerebrosidase activity|upregulation of glucosylsphingosine beta-D-glucosidase activity|upregulation of glucosylsphingosine beta-glucosidase activity|upregulation of psychosine hydrolase activity http://purl.obolibrary.org/obo/GO_1905125 gocheck_do_not_annotate GO:0090327 biolink:BiologicalProcess negative regulation of locomotion involved in locomotory behavior Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. go.json http://purl.obolibrary.org/obo/GO_0090327 GO:1905126 biolink:BiologicalProcess regulation of axo-dendritic protein transport Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. go.json regulation of axonal protein transport http://purl.obolibrary.org/obo/GO_1905126 GO:0090328 biolink:BiologicalProcess regulation of olfactory learning Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. go.json http://purl.obolibrary.org/obo/GO_0090328 GO:0090325 biolink:BiologicalProcess regulation of locomotion involved in locomotory behavior Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. go.json http://purl.obolibrary.org/obo/GO_0090325 GO:1905127 biolink:BiologicalProcess negative regulation of axo-dendritic protein transport Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. go.json down regulation of axo-dendritic protein transport|down regulation of axonal protein transport|down-regulation of axo-dendritic protein transport|down-regulation of axonal protein transport|downregulation of axo-dendritic protein transport|downregulation of axonal protein transport|inhibition of axo-dendritic protein transport|inhibition of axonal protein transport|negative regulation of axonal protein transport http://purl.obolibrary.org/obo/GO_1905127 GO:1905128 biolink:BiologicalProcess positive regulation of axo-dendritic protein transport Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. go.json activation of axo-dendritic protein transport|activation of axonal protein transport|positive regulation of axonal protein transport|up regulation of axo-dendritic protein transport|up regulation of axonal protein transport|up-regulation of axo-dendritic protein transport|up-regulation of axonal protein transport|upregulation of axo-dendritic protein transport|upregulation of axonal protein transport http://purl.obolibrary.org/obo/GO_1905128 GO:0090326 biolink:BiologicalProcess positive regulation of locomotion involved in locomotory behavior Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. go.json http://purl.obolibrary.org/obo/GO_0090326 GO:1905129 biolink:BiologicalProcess endocannabinoid signaling pathway involved in trans-synaptic signaling Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid. go.json endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid http://purl.obolibrary.org/obo/GO_1905129 GO:0090329 biolink:BiologicalProcess regulation of DNA-templated DNA replication Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized. go.json regulation of DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0090329 GO:0090320 biolink:BiologicalProcess regulation of chylomicron remnant clearance Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0090320 GO:0090323 biolink:BiologicalProcess prostaglandin secretion involved in immune response The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring. go.json http://purl.obolibrary.org/obo/GO_0090323 gocheck_do_not_annotate GO:0090324 biolink:BiologicalProcess negative regulation of oxidative phosphorylation Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. go.json http://purl.obolibrary.org/obo/GO_0090324 GO:0090321 biolink:BiologicalProcess positive regulation of chylomicron remnant clearance Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0090321 GO:0090322 biolink:BiologicalProcess regulation of superoxide metabolic process Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. go.json regulation of superoxide metabolism http://purl.obolibrary.org/obo/GO_0090322 GO:1905140 biolink:BiologicalProcess regulation of apical ectodermal ridge formation Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. go.json regulation of AER formation|regulation of apical epidermal ridge formation|regulation of crista ectodermalis apicalis formation http://purl.obolibrary.org/obo/GO_1905140 GO:1905141 biolink:BiologicalProcess negative regulation of apical ectodermal ridge formation Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. go.json down regulation of AER formation|down regulation of apical ectodermal ridge formation|down regulation of apical epidermal ridge formation|down regulation of crista ectodermalis apicalis formation|down-regulation of AER formation|down-regulation of apical ectodermal ridge formation|down-regulation of apical epidermal ridge formation|down-regulation of crista ectodermalis apicalis formation|downregulation of AER formation|downregulation of apical ectodermal ridge formation|downregulation of apical epidermal ridge formation|downregulation of crista ectodermalis apicalis formation|inhibition of AER formation|inhibition of apical ectodermal ridge formation|inhibition of apical epidermal ridge formation|inhibition of crista ectodermalis apicalis formation|negative regulation of AER formation|negative regulation of apical epidermal ridge formation|negative regulation of crista ectodermalis apicalis formation http://purl.obolibrary.org/obo/GO_1905141 GO:1905142 biolink:BiologicalProcess positive regulation of apical ectodermal ridge formation Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. go.json activation of AER formation|positive regulation of AER formation|positive regulation of apical epidermal ridge formation|positive regulation of crista ectodermalis apicalis formation|up regulation of AER formation|up regulation of apical ectodermal ridge formation|up regulation of apical epidermal ridge formation|up regulation of crista ectodermalis apicalis formation|up-regulation of AER formation|up-regulation of apical ectodermal ridge formation|up-regulation of apical epidermal ridge formation|up-regulation of crista ectodermalis apicalis formation|upregulation of AER formation|upregulation of apical ectodermal ridge formation|upregulation of apical epidermal ridge formation|upregulation of crista ectodermalis apicalis formation http://purl.obolibrary.org/obo/GO_1905142 GO:1905143 biolink:BiologicalProcess eukaryotic translation initiation factor 2 complex assembly The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex. go.json eIF-2 assembly|eIF-2 formation|eIF2 assembly|eIF2 formation|eukaryotic translation initiation factor 2 complex formation http://purl.obolibrary.org/obo/GO_1905143 GO:1905144 biolink:BiologicalProcess response to acetylcholine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. go.json http://purl.obolibrary.org/obo/GO_1905144 GO:1905145 biolink:BiologicalProcess cellular response to acetylcholine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. go.json http://purl.obolibrary.org/obo/GO_1905145 GO:1905146 biolink:BiologicalProcess lysosomal protein catabolic process Any cellular protein catabolic process that takes place in a lysosome. go.json cellular protein breakdown in lysosome|cellular protein catabolic process in lysosome|cellular protein catabolism in lysosome|cellular protein degradation in lysosome|lysosomal protein catabolism|lysosomal protein degradation|lysosomal proteolysis|proteolysis within lysosome http://purl.obolibrary.org/obo/GO_1905146 GO:1905136 biolink:BiologicalProcess dethiobiotin import across plasma membrane The directed movement of dethiobiotin from outside of a cell, across the plasma membrane and into the cytosol. go.json dethiobiotin import|dethiobiotin import into cell http://purl.obolibrary.org/obo/GO_1905136 GO:0090338 biolink:BiologicalProcess positive regulation of formin-nucleated actin cable assembly Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. go.json http://purl.obolibrary.org/obo/GO_0090338 GO:1905137 biolink:BiologicalProcess regulation of viral DNA genome packaging via site-specific sequence recognition Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. go.json http://purl.obolibrary.org/obo/GO_1905137 GO:0090339 biolink:BiologicalProcess negative regulation of formin-nucleated actin cable assembly Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. go.json http://purl.obolibrary.org/obo/GO_0090339 GO:1905138 biolink:BiologicalProcess positive regulation of viral DNA genome packaging via site-specific sequence recognition Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. go.json activation of viral DNA genome packaging via site-specific sequence recognition|up regulation of viral DNA genome packaging via site-specific sequence recognition|up-regulation of viral DNA genome packaging via site-specific sequence recognition|upregulation of viral DNA genome packaging via site-specific sequence recognition http://purl.obolibrary.org/obo/GO_1905138 GO:0090336 biolink:BiologicalProcess positive regulation of brown fat cell differentiation Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. go.json http://purl.obolibrary.org/obo/GO_0090336 GO:1905139 biolink:BiologicalProcess apical ectodermal ridge formation The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. go.json AER formation|apical epidermal ridge formation|crista ectodermalis apicalis formation http://purl.obolibrary.org/obo/GO_1905139 GO:0090337 biolink:BiologicalProcess regulation of formin-nucleated actin cable assembly Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. go.json http://purl.obolibrary.org/obo/GO_0090337 GO:0090330 biolink:BiologicalProcess regulation of platelet aggregation Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0090330 GO:0090331 biolink:BiologicalProcess negative regulation of platelet aggregation Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. go.json platelet disaggregation http://purl.obolibrary.org/obo/GO_0090331 GO:0090334 biolink:BiologicalProcess regulation of cell wall (1->3)-beta-D-glucan biosynthetic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. go.json regulation of cell wall 1,3-beta-D-glucan biosynthetic process|regulation of cell wall 1,3-beta-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0090334 GO:0090335 biolink:BiologicalProcess regulation of brown fat cell differentiation Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. go.json http://purl.obolibrary.org/obo/GO_0090335 GO:0090332 biolink:BiologicalProcess stomatal closure The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. go.json http://purl.obolibrary.org/obo/GO_0090332 GO:0090333 biolink:BiologicalProcess regulation of stomatal closure Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. go.json http://purl.obolibrary.org/obo/GO_0090333 GO:1905150 biolink:BiologicalProcess regulation of voltage-gated sodium channel activity Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity. go.json regulation of voltage gated sodium channel activity|regulation of voltage-dependent sodium channel activity|regulation of voltage-gated sodium ion channel activity|regulation of voltage-sensitive sodium channel http://purl.obolibrary.org/obo/GO_1905150 gocheck_do_not_annotate GO:1905151 biolink:BiologicalProcess negative regulation of voltage-gated sodium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity. go.json down regulation of voltage gated sodium channel activity|down regulation of voltage-dependent sodium channel activity|down regulation of voltage-gated sodium channel activity|down regulation of voltage-gated sodium ion channel activity|down regulation of voltage-sensitive sodium channel|down-regulation of voltage gated sodium channel activity|down-regulation of voltage-dependent sodium channel activity|down-regulation of voltage-gated sodium channel activity|down-regulation of voltage-gated sodium ion channel activity|down-regulation of voltage-sensitive sodium channel|downregulation of voltage gated sodium channel activity|downregulation of voltage-dependent sodium channel activity|downregulation of voltage-gated sodium channel activity|downregulation of voltage-gated sodium ion channel activity|downregulation of voltage-sensitive sodium channel|inhibition of voltage gated sodium channel activity|inhibition of voltage-dependent sodium channel activity|inhibition of voltage-gated sodium channel activity|inhibition of voltage-gated sodium ion channel activity|inhibition of voltage-sensitive sodium channel|negative regulation of voltage gated sodium channel activity|negative regulation of voltage-dependent sodium channel activity|negative regulation of voltage-gated sodium ion channel activity|negative regulation of voltage-sensitive sodium channel http://purl.obolibrary.org/obo/GO_1905151 gocheck_do_not_annotate GO:1905152 biolink:BiologicalProcess positive regulation of voltage-gated sodium channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity. go.json activation of voltage gated sodium channel activity|activation of voltage-dependent sodium channel activity|activation of voltage-gated sodium channel activity|activation of voltage-gated sodium ion channel activity|activation of voltage-sensitive sodium channel|positive regulation of voltage gated sodium channel activity|positive regulation of voltage-dependent sodium channel activity|positive regulation of voltage-gated sodium ion channel activity|positive regulation of voltage-sensitive sodium channel|up regulation of voltage gated sodium channel activity|up regulation of voltage-dependent sodium channel activity|up regulation of voltage-gated sodium channel activity|up regulation of voltage-gated sodium ion channel activity|up regulation of voltage-sensitive sodium channel|up-regulation of voltage gated sodium channel activity|up-regulation of voltage-dependent sodium channel activity|up-regulation of voltage-gated sodium channel activity|up-regulation of voltage-gated sodium ion channel activity|up-regulation of voltage-sensitive sodium channel|upregulation of voltage gated sodium channel activity|upregulation of voltage-dependent sodium channel activity|upregulation of voltage-gated sodium channel activity|upregulation of voltage-gated sodium ion channel activity|upregulation of voltage-sensitive sodium channel http://purl.obolibrary.org/obo/GO_1905152 gocheck_do_not_annotate GO:1905153 biolink:BiologicalProcess regulation of membrane invagination Any process that modulates the frequency, rate or extent of membrane invagination. go.json http://purl.obolibrary.org/obo/GO_1905153 GO:1905154 biolink:BiologicalProcess negative regulation of membrane invagination Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. go.json down regulation of membrane invagination|down-regulation of membrane invagination|downregulation of membrane invagination|inhibition of membrane invagination http://purl.obolibrary.org/obo/GO_1905154 GO:1905155 biolink:BiologicalProcess positive regulation of membrane invagination Any process that activates or increases the frequency, rate or extent of membrane invagination. go.json activation of membrane invagination|up regulation of membrane invagination|up-regulation of membrane invagination|upregulation of membrane invagination http://purl.obolibrary.org/obo/GO_1905155 GO:1905156 biolink:BiologicalProcess negative regulation of photosynthesis Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis. go.json down regulation of photosynthesis|down-regulation of photosynthesis|downregulation of photosynthesis|inhibition of photosynthesis http://purl.obolibrary.org/obo/GO_1905156 GO:1905157 biolink:BiologicalProcess positive regulation of photosynthesis Any process that activates or increases the frequency, rate or extent of photosynthesis. go.json activation of photosynthesis|up regulation of photosynthesis|up-regulation of photosynthesis|upregulation of photosynthesis http://purl.obolibrary.org/obo/GO_1905157 GO:0090305 biolink:BiologicalProcess nucleic acid phosphodiester bond hydrolysis The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. go.json nucleic acid cleavage http://purl.obolibrary.org/obo/GO_0090305 GO:1905147 biolink:BiologicalProcess regulation of smooth muscle hypertrophy Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. go.json http://purl.obolibrary.org/obo/GO_1905147 GO:1905148 biolink:BiologicalProcess negative regulation of smooth muscle hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. go.json down regulation of smooth muscle hypertrophy|down-regulation of smooth muscle hypertrophy|downregulation of smooth muscle hypertrophy|inhibition of smooth muscle hypertrophy http://purl.obolibrary.org/obo/GO_1905148 GO:0090306 biolink:BiologicalProcess meiotic spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis. go.json spindle assembly involved in meiosis http://purl.obolibrary.org/obo/GO_0090306 GO:1905149 biolink:BiologicalProcess positive regulation of smooth muscle hypertrophy Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. go.json activation of smooth muscle hypertrophy|up regulation of smooth muscle hypertrophy|up-regulation of smooth muscle hypertrophy|upregulation of smooth muscle hypertrophy http://purl.obolibrary.org/obo/GO_1905149 GO:0090303 biolink:BiologicalProcess positive regulation of wound healing Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. go.json http://purl.obolibrary.org/obo/GO_0090303 GO:0090304 biolink:BiologicalProcess nucleic acid metabolic process Any cellular metabolic process involving nucleic acids. go.json http://purl.obolibrary.org/obo/GO_0090304 GO:0090309 biolink:BiologicalProcess positive regulation of DNA methylation-dependent heterochromatin formation Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. go.json positive regulation of DNA methylation-dependent heterochromatin assembly|positive regulation of methylation-dependent chromatin silencing http://purl.obolibrary.org/obo/GO_0090309 GO:0090307 biolink:BiologicalProcess mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. go.json spindle assembly involved in mitosis http://purl.obolibrary.org/obo/GO_0090307 GO:0090308 biolink:BiologicalProcess regulation of DNA methylation-dependent heterochromatin formation Any process that modulates the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. go.json regulation of DNA methylation-dependent heterochromatin assembly|regulation of methylation-dependent chromatin silencing http://purl.obolibrary.org/obo/GO_0090308 GO:0090301 biolink:BiologicalProcess negative regulation of neural crest formation Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. go.json http://purl.obolibrary.org/obo/GO_0090301 GO:0090302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090302 GO:0090300 biolink:BiologicalProcess positive regulation of neural crest formation Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. go.json http://purl.obolibrary.org/obo/GO_0090300 GO:1905160 biolink:BiologicalProcess obsolete positive regulation of Factor XII activation OBSOLETE. Any process that activates or increases the frequency, rate or extent of Factor XII activation. go.json activation of Factor XII activation|activation of Hageman factor activation|positive regulation of Hageman factor activation|up regulation of Factor XII activation|up regulation of Hageman factor activation|up-regulation of Factor XII activation|up-regulation of Hageman factor activation|upregulation of Factor XII activation|upregulation of Hageman factor activation True http://purl.obolibrary.org/obo/GO_1905160 GO:1905161 biolink:BiologicalProcess protein localization to phagocytic vesicle A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle. go.json protein localisation in phagocytic vesicle|protein localisation to phagocytic vesicle|protein localisation to phagosome|protein localization in phagocytic vesicle|protein recruitment to phagosome http://purl.obolibrary.org/obo/GO_1905161 GO:1905162 biolink:BiologicalProcess regulation of phagosome maturation Any process that modulates the frequency, rate or extent of phagosome maturation. go.json http://purl.obolibrary.org/obo/GO_1905162 GO:1905163 biolink:BiologicalProcess negative regulation of phagosome maturation Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation. go.json down regulation of phagosome maturation|down-regulation of phagosome maturation|downregulation of phagosome maturation|inhibition of phagosome maturation http://purl.obolibrary.org/obo/GO_1905163 GO:1905164 biolink:BiologicalProcess positive regulation of phagosome maturation Any process that activates or increases the frequency, rate or extent of phagosome maturation. go.json activation of phagosome maturation|up regulation of phagosome maturation|up-regulation of phagosome maturation|upregulation of phagosome maturation http://purl.obolibrary.org/obo/GO_1905164 GO:1905165 biolink:BiologicalProcess regulation of lysosomal protein catabolic process Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. go.json regulation of cellular protein breakdown in lysosome|regulation of cellular protein catabolic process in lysosome|regulation of cellular protein catabolism in lysosome|regulation of cellular protein degradation in lysosome|regulation of lysosomal protein catabolism|regulation of lysosomal protein degradation|regulation of lysosomal proteolysis|regulation of proteolysis within lysosome http://purl.obolibrary.org/obo/GO_1905165 GO:1905166 biolink:BiologicalProcess negative regulation of lysosomal protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. go.json down regulation of cellular protein breakdown in lysosome|down regulation of cellular protein catabolic process in lysosome|down regulation of cellular protein catabolism in lysosome|down regulation of cellular protein degradation in lysosome|down regulation of lysosomal protein catabolic process|down regulation of lysosomal protein catabolism|down regulation of lysosomal protein degradation|down regulation of lysosomal proteolysis|down regulation of proteolysis within lysosome|down-regulation of cellular protein breakdown in lysosome|down-regulation of cellular protein catabolic process in lysosome|down-regulation of cellular protein catabolism in lysosome|down-regulation of cellular protein degradation in lysosome|down-regulation of lysosomal protein catabolic process|down-regulation of lysosomal protein catabolism|down-regulation of lysosomal protein degradation|down-regulation of lysosomal proteolysis|down-regulation of proteolysis within lysosome|downregulation of cellular protein breakdown in lysosome|downregulation of cellular protein catabolic process in lysosome|downregulation of cellular protein catabolism in lysosome|downregulation of cellular protein degradation in lysosome|downregulation of lysosomal protein catabolic process|downregulation of lysosomal protein catabolism|downregulation of lysosomal protein degradation|downregulation of lysosomal proteolysis|downregulation of proteolysis within lysosome|inhibition of cellular protein breakdown in lysosome|inhibition of cellular protein catabolic process in lysosome|inhibition of cellular protein catabolism in lysosome|inhibition of cellular protein degradation in lysosome|inhibition of lysosomal protein catabolic process|inhibition of lysosomal protein catabolism|inhibition of lysosomal protein degradation|inhibition of lysosomal proteolysis|inhibition of proteolysis within lysosome|negative regulation of cellular protein breakdown in lysosome|negative regulation of cellular protein catabolic process in lysosome|negative regulation of cellular protein catabolism in lysosome|negative regulation of cellular protein degradation in lysosome|negative regulation of lysosomal protein catabolism|negative regulation of lysosomal protein degradation|negative regulation of lysosomal proteolysis|negative regulation of proteolysis within lysosome http://purl.obolibrary.org/obo/GO_1905166 GO:1905167 biolink:BiologicalProcess positive regulation of lysosomal protein catabolic process Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. go.json activation of cellular protein breakdown in lysosome|activation of cellular protein catabolic process in lysosome|activation of cellular protein catabolism in lysosome|activation of cellular protein degradation in lysosome|activation of lysosomal protein catabolic process|activation of lysosomal protein catabolism|activation of lysosomal protein degradation|activation of lysosomal proteolysis|activation of proteolysis within lysosome|positive regulation of cellular protein breakdown in lysosome|positive regulation of cellular protein catabolic process in lysosome|positive regulation of cellular protein catabolism in lysosome|positive regulation of cellular protein degradation in lysosome|positive regulation of lysosomal protein catabolism|positive regulation of lysosomal protein degradation|positive regulation of lysosomal proteolysis|positive regulation of proteolysis within lysosome|up regulation of cellular protein breakdown in lysosome|up regulation of cellular protein catabolic process in lysosome|up regulation of cellular protein catabolism in lysosome|up regulation of cellular protein degradation in lysosome|up regulation of lysosomal protein catabolic process|up regulation of lysosomal protein catabolism|up regulation of lysosomal protein degradation|up regulation of lysosomal proteolysis|up regulation of proteolysis within lysosome|up-regulation of cellular protein breakdown in lysosome|up-regulation of cellular protein catabolic process in lysosome|up-regulation of cellular protein catabolism in lysosome|up-regulation of cellular protein degradation in lysosome|up-regulation of lysosomal protein catabolic process|up-regulation of lysosomal protein catabolism|up-regulation of lysosomal protein degradation|up-regulation of lysosomal proteolysis|up-regulation of proteolysis within lysosome|upregulation of cellular protein breakdown in lysosome|upregulation of cellular protein catabolic process in lysosome|upregulation of cellular protein catabolism in lysosome|upregulation of cellular protein degradation in lysosome|upregulation of lysosomal protein catabolic process|upregulation of lysosomal protein catabolism|upregulation of lysosomal protein degradation|upregulation of lysosomal proteolysis|upregulation of proteolysis within lysosome http://purl.obolibrary.org/obo/GO_1905167 GO:1905168 biolink:BiologicalProcess positive regulation of double-strand break repair via homologous recombination Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination. go.json activation of HDR|activation of HRR|activation of Rad51-dependent recombinational repair|activation of Rhp51-dependent recombinational repair|activation of double-strand break repair via homologous recombination|activation of homologous recombinational repair|activation of homology-directed repair|positive regulation of HDR|positive regulation of HRR|positive regulation of Rad51-dependent recombinational repair|positive regulation of Rhp51-dependent recombinational repair|positive regulation of homologous recombinational repair|positive regulation of homology-directed repair|up regulation of HDR|up regulation of HRR|up regulation of Rad51-dependent recombinational repair|up regulation of Rhp51-dependent recombinational repair|up regulation of double-strand break repair via homologous recombination|up regulation of homologous recombinational repair|up regulation of homology-directed repair|up-regulation of HDR|up-regulation of HRR|up-regulation of Rad51-dependent recombinational repair|up-regulation of Rhp51-dependent recombinational repair|up-regulation of double-strand break repair via homologous recombination|up-regulation of homologous recombinational repair|up-regulation of homology-directed repair|upregulation of HDR|upregulation of HRR|upregulation of Rad51-dependent recombinational repair|upregulation of Rhp51-dependent recombinational repair|upregulation of double-strand break repair via homologous recombination|upregulation of homologous recombinational repair|upregulation of homology-directed repair http://purl.obolibrary.org/obo/GO_1905168 GO:0090316 biolink:BiologicalProcess positive regulation of intracellular protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. go.json http://purl.obolibrary.org/obo/GO_0090316 GO:1905158 biolink:BiologicalProcess obsolete regulation of Factor XII activation OBSOLETE. Any process that modulates the frequency, rate or extent of Factor XII activation. go.json regulation of Hageman factor activation True http://purl.obolibrary.org/obo/GO_1905158 GO:1905159 biolink:BiologicalProcess obsolete negative regulation of Factor XII activation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Factor XII activation. go.json down regulation of Factor XII activation|down regulation of Hageman factor activation|down-regulation of Factor XII activation|down-regulation of Hageman factor activation|downregulation of Factor XII activation|downregulation of Hageman factor activation|inhibition of Factor XII activation|inhibition of Hageman factor activation|negative regulation of Hageman factor activation True http://purl.obolibrary.org/obo/GO_1905159 GO:0090317 biolink:BiologicalProcess negative regulation of intracellular protein transport Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. go.json http://purl.obolibrary.org/obo/GO_0090317 GO:0090314 biolink:BiologicalProcess positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. go.json http://purl.obolibrary.org/obo/GO_0090314 GO:0090315 biolink:BiologicalProcess negative regulation of protein targeting to membrane Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. go.json http://purl.obolibrary.org/obo/GO_0090315 GO:0090318 biolink:BiologicalProcess regulation of chylomicron remodeling Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. go.json regulation of chylomicron remodelling http://purl.obolibrary.org/obo/GO_0090318 GO:0090319 biolink:BiologicalProcess positive regulation of chylomicron remodeling Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. go.json positive regulation of chylomicron remodelling http://purl.obolibrary.org/obo/GO_0090319 GO:0090312 biolink:BiologicalProcess positive regulation of protein deacetylation Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json positive regulation of protein amino acid deacetylation http://purl.obolibrary.org/obo/GO_0090312 GO:0090313 biolink:BiologicalProcess regulation of protein targeting to membrane Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. go.json http://purl.obolibrary.org/obo/GO_0090313 GO:0090310 biolink:BiologicalProcess negative regulation of DNA methylation-dependent heterochromatin formation Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. go.json negative regulation of DNA methylation-dependent heterochromatin assembly|negative regulation of methylation-dependent chromatin silencing http://purl.obolibrary.org/obo/GO_0090310 GO:0090311 biolink:BiologicalProcess regulation of protein deacetylation Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json regulation of protein amino acid deacetylation http://purl.obolibrary.org/obo/GO_0090311 GO:0090360 biolink:BiologicalProcess platelet-derived growth factor production The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090360 gocheck_do_not_annotate GO:1905170 biolink:BiologicalProcess negative regulation of protein localization to phagocytic vesicle Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle. go.json down regulation of protein localisation in phagocytic vesicle|down regulation of protein localisation to phagocytic vesicle|down regulation of protein localisation to phagosome|down regulation of protein localization in phagocytic vesicle|down regulation of protein localization to phagocytic vesicle|down regulation of protein recruitment to phagosome|down-regulation of protein localisation in phagocytic vesicle|down-regulation of protein localisation to phagocytic vesicle|down-regulation of protein localisation to phagosome|down-regulation of protein localization in phagocytic vesicle|down-regulation of protein localization to phagocytic vesicle|down-regulation of protein recruitment to phagosome|downregulation of protein localisation in phagocytic vesicle|downregulation of protein localisation to phagocytic vesicle|downregulation of protein localisation to phagosome|downregulation of protein localization in phagocytic vesicle|downregulation of protein localization to phagocytic vesicle|downregulation of protein recruitment to phagosome|inhibition of protein localisation in phagocytic vesicle|inhibition of protein localisation to phagocytic vesicle|inhibition of protein localisation to phagosome|inhibition of protein localization in phagocytic vesicle|inhibition of protein localization to phagocytic vesicle|inhibition of protein recruitment to phagosome|negative regulation of protein localisation in phagocytic vesicle|negative regulation of protein localisation to phagocytic vesicle|negative regulation of protein localisation to phagosome|negative regulation of protein localization in phagocytic vesicle|negative regulation of protein recruitment to phagosome http://purl.obolibrary.org/obo/GO_1905170 GO:1905171 biolink:BiologicalProcess positive regulation of protein localization to phagocytic vesicle Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle. go.json activation of protein localisation in phagocytic vesicle|activation of protein localisation to phagocytic vesicle|activation of protein localisation to phagosome|activation of protein localization in phagocytic vesicle|activation of protein localization to phagocytic vesicle|activation of protein recruitment to phagosome|positive regulation of protein localisation in phagocytic vesicle|positive regulation of protein localisation to phagocytic vesicle|positive regulation of protein localisation to phagosome|positive regulation of protein localization in phagocytic vesicle|positive regulation of protein recruitment to phagosome|up regulation of protein localisation in phagocytic vesicle|up regulation of protein localisation to phagocytic vesicle|up regulation of protein localisation to phagosome|up regulation of protein localization in phagocytic vesicle|up regulation of protein localization to phagocytic vesicle|up regulation of protein recruitment to phagosome|up-regulation of protein localisation in phagocytic vesicle|up-regulation of protein localisation to phagocytic vesicle|up-regulation of protein localisation to phagosome|up-regulation of protein localization in phagocytic vesicle|up-regulation of protein localization to phagocytic vesicle|up-regulation of protein recruitment to phagosome|upregulation of protein localisation in phagocytic vesicle|upregulation of protein localisation to phagocytic vesicle|upregulation of protein localisation to phagosome|upregulation of protein localization in phagocytic vesicle|upregulation of protein localization to phagocytic vesicle|upregulation of protein recruitment to phagosome http://purl.obolibrary.org/obo/GO_1905171 GO:1905172 biolink:MolecularActivity RISC complex binding Binding to a RISC complex. go.json RNA-induced silencing complex binding http://purl.obolibrary.org/obo/GO_1905172 GO:1905173 biolink:BiologicalProcess eukaryotic translation initiation factor 2B complex assembly The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2B complex. go.json eIF-2B assembly|eIF-2B formation|eif2B assembly|eif2B formation|eukaryotic translation initiation factor 2B complex formation http://purl.obolibrary.org/obo/GO_1905173 GO:1905174 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell dedifferentiation Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. go.json regulation of vascular smooth muscle cell dedifferentiation http://purl.obolibrary.org/obo/GO_1905174 GO:1905175 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle cell dedifferentiation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. go.json down regulation of vascular smooth muscle cell dedifferentiation|down-regulation of vascular smooth muscle cell dedifferentiation|downregulation of vascular smooth muscle cell dedifferentiation|inhibition of vascular smooth muscle cell dedifferentiation|negative regulation of vascular smooth muscle cell dedifferentiation http://purl.obolibrary.org/obo/GO_1905175 GO:1905176 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle cell dedifferentiation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. go.json activation of vascular smooth muscle cell dedifferentiation|positive regulation of vascular smooth muscle cell dedifferentiation|up regulation of vascular smooth muscle cell dedifferentiation|up-regulation of vascular smooth muscle cell dedifferentiation|upregulation of vascular smooth muscle cell dedifferentiation http://purl.obolibrary.org/obo/GO_1905176 GO:1905177 biolink:BiologicalProcess tracheary element differentiation The process in which a relatively unspecialized cell acquires the specialized features of a tracheary element. go.json http://purl.obolibrary.org/obo/GO_1905177 GO:1905178 biolink:BiologicalProcess regulation of cardiac muscle tissue regeneration Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration. go.json http://purl.obolibrary.org/obo/GO_1905178 GO:1905179 biolink:BiologicalProcess negative regulation of cardiac muscle tissue regeneration Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration. go.json down regulation of cardiac muscle tissue regeneration|down-regulation of cardiac muscle tissue regeneration|downregulation of cardiac muscle tissue regeneration|inhibition of cardiac muscle tissue regeneration http://purl.obolibrary.org/obo/GO_1905179 GO:1905169 biolink:BiologicalProcess regulation of protein localization to phagocytic vesicle Any process that modulates the frequency, rate or extent of protein localization to phagocytic vesicle. go.json regulation of protein localisation in phagocytic vesicle|regulation of protein localisation to phagocytic vesicle|regulation of protein localisation to phagosome|regulation of protein localization in phagocytic vesicle|regulation of protein recruitment to phagosome http://purl.obolibrary.org/obo/GO_1905169 GO:0090369 biolink:MolecularActivity ornithine carbamoyltransferase inhibitor activity Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase. go.json http://purl.obolibrary.org/obo/GO_0090369 GO:0090363 biolink:BiologicalProcess regulation of proteasome core complex assembly Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles. go.json http://purl.obolibrary.org/obo/GO_0090363 GO:0090364 biolink:BiologicalProcess regulation of proteasome assembly Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex. go.json http://purl.obolibrary.org/obo/GO_0090364 GO:0090361 biolink:BiologicalProcess regulation of platelet-derived growth factor production Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090361 GO:0090362 biolink:BiologicalProcess positive regulation of platelet-derived growth factor production Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090362 GO:0090367 biolink:BiologicalProcess negative regulation of mRNA modification Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. go.json http://purl.obolibrary.org/obo/GO_0090367 GO:0090368 biolink:BiologicalProcess regulation of ornithine metabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0090368 GO:0090365 biolink:BiologicalProcess regulation of mRNA modification Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. go.json regulation of mRNA editing http://purl.obolibrary.org/obo/GO_0090365 GO:0090366 biolink:BiologicalProcess positive regulation of mRNA modification Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. go.json http://purl.obolibrary.org/obo/GO_0090366 GO:0090370 biolink:BiologicalProcess negative regulation of cholesterol efflux Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0090370 GO:1905180 biolink:BiologicalProcess positive regulation of cardiac muscle tissue regeneration Any process that activates or increases the frequency, rate or extent of cardiac muscle tissue regeneration. go.json activation of cardiac muscle tissue regeneration|up regulation of cardiac muscle tissue regeneration|up-regulation of cardiac muscle tissue regeneration|upregulation of cardiac muscle tissue regeneration http://purl.obolibrary.org/obo/GO_1905180 GO:0090371 biolink:BiologicalProcess regulation of glycerol transport Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0090371 GO:1905181 biolink:BiologicalProcess regulation of urease activity Any process that modulates the frequency, rate or extent of urease activity. go.json regulation of urea amidohydrolase activity http://purl.obolibrary.org/obo/GO_1905181 gocheck_do_not_annotate GO:1905182 biolink:BiologicalProcess positive regulation of urease activity Any process that activates or increases the frequency, rate or extent of urease activity. go.json activation of urea amidohydrolase activity|activation of urease activity|positive regulation of urea amidohydrolase activity|up regulation of urea amidohydrolase activity|up regulation of urease activity|up-regulation of urea amidohydrolase activity|up-regulation of urease activity|upregulation of urea amidohydrolase activity|upregulation of urease activity http://purl.obolibrary.org/obo/GO_1905182 gocheck_do_not_annotate GO:1905183 biolink:BiologicalProcess negative regulation of protein serine/threonine phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity. go.json down regulation of protein serine/threonine phosphatase activity|down regulation of serine/threonine specific protein phosphatase activity|down-regulation of protein serine/threonine phosphatase activity|down-regulation of serine/threonine specific protein phosphatase activity|downregulation of protein serine/threonine phosphatase activity|downregulation of serine/threonine specific protein phosphatase activity|inhibition of protein serine/threonine phosphatase activity|inhibition of serine/threonine specific protein phosphatase activity|negative regulation of serine/threonine specific protein phosphatase activity http://purl.obolibrary.org/obo/GO_1905183 gocheck_do_not_annotate GO:1905184 biolink:BiologicalProcess positive regulation of protein serine/threonine phosphatase activity Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity. go.json activation of protein serine/threonine phosphatase activity|activation of serine/threonine specific protein phosphatase activity|positive regulation of serine/threonine specific protein phosphatase activity|up regulation of protein serine/threonine phosphatase activity|up regulation of serine/threonine specific protein phosphatase activity|up-regulation of protein serine/threonine phosphatase activity|up-regulation of serine/threonine specific protein phosphatase activity|upregulation of protein serine/threonine phosphatase activity|upregulation of serine/threonine specific protein phosphatase activity http://purl.obolibrary.org/obo/GO_1905184 gocheck_do_not_annotate GO:1905185 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905185 GO:1905186 biolink:BiologicalProcess regulation of metaphase/anaphase transition of meiosis I Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I. go.json regulation of first meiotic metaphase/anaphase transition|regulation of meiosis I metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1905186 GO:1905187 biolink:BiologicalProcess negative regulation of metaphase/anaphase transition of meiosis I Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis I. go.json http://purl.obolibrary.org/obo/GO_1905187 GO:1905188 biolink:BiologicalProcess positive regulation of metaphase/anaphase transition of meiosis I Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I. go.json positive regulation of meiosis I metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1905188 GO:1905189 biolink:BiologicalProcess regulation of metaphase/anaphase transition of meiosis II Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis II. go.json regulation of meiosis II metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1905189 GO:0090374 biolink:BiologicalProcess oligopeptide export from mitochondrion The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. go.json http://purl.obolibrary.org/obo/GO_0090374 GO:0090375 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. go.json negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency http://purl.obolibrary.org/obo/GO_0090375 GO:0090372 biolink:BiologicalProcess positive regulation of glycerol transport Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0090372 GO:0090373 biolink:BiologicalProcess negative regulation of glycerol transport Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0090373 GO:0090378 biolink:BiologicalProcess seed trichome elongation The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. go.json http://purl.obolibrary.org/obo/GO_0090378 GO:0090379 biolink:BiologicalProcess secondary cell wall biogenesis involved in seed trichome differentiation A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete. go.json secondary cell wall biosynthesis involved in seed trichome differentiation|seed trichome secondary wall biosynthesis http://purl.obolibrary.org/obo/GO_0090379 GO:0090376 biolink:BiologicalProcess seed trichome differentiation The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function. go.json cotton fiber development|seed hair differentiation|seed trichome development http://purl.obolibrary.org/obo/GO_0090376 GO:0090377 biolink:BiologicalProcess seed trichome initiation The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis. go.json seed trichome fate commitment http://purl.obolibrary.org/obo/GO_0090377 GO:1905190 biolink:BiologicalProcess negative regulation of metaphase/anaphase transition of meiosis II Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis II. go.json negative regulation of meiosis II metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1905190 GO:1905191 biolink:BiologicalProcess positive regulation of metaphase/anaphase transition of meiosis II Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis II. go.json positive regulation of meiosis II metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1905191 GO:1905192 biolink:BiologicalProcess regulation of chloroplast fission Any process that modulates the frequency, rate or extent of chloroplast fission. go.json regulation of chloroplast division http://purl.obolibrary.org/obo/GO_1905192 GO:1905193 biolink:BiologicalProcess negative regulation of chloroplast fission Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission. go.json down regulation of chloroplast division|down regulation of chloroplast fission|down-regulation of chloroplast division|down-regulation of chloroplast fission|downregulation of chloroplast division|downregulation of chloroplast fission|inhibition of chloroplast division|inhibition of chloroplast fission|negative regulation of chloroplast division http://purl.obolibrary.org/obo/GO_1905193 GO:1905194 biolink:BiologicalProcess positive regulation of chloroplast fission Any process that activates or increases the frequency, rate or extent of chloroplast fission. go.json activation of chloroplast division|activation of chloroplast fission|positive regulation of chloroplast division|up regulation of chloroplast division|up regulation of chloroplast fission|up-regulation of chloroplast division|up-regulation of chloroplast fission|upregulation of chloroplast division|upregulation of chloroplast fission http://purl.obolibrary.org/obo/GO_1905194 GO:1905195 biolink:BiologicalProcess obsolete regulation of ATPase activity, uncoupled OBSOLETE. Any process that modulates the frequency, rate or extent of ATPase activity, uncoupled. go.json regulation of adenylpyrophosphatase activity True http://purl.obolibrary.org/obo/GO_1905195 GO:1905196 biolink:BiologicalProcess obsolete positive regulation of ATPase activity, uncoupled OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATPase activity, uncoupled. go.json activation of ATPase activity, uncoupled|activation of adenylpyrophosphatase activity|positive regulation of adenylpyrophosphatase activity|up regulation of ATPase activity, uncoupled|up regulation of adenylpyrophosphatase activity|up-regulation of ATPase activity, uncoupled|up-regulation of adenylpyrophosphatase activity|upregulation of ATPase activity, uncoupled|upregulation of adenylpyrophosphatase activity True http://purl.obolibrary.org/obo/GO_1905196 GO:1905197 biolink:BiologicalProcess endocannabinoid signaling pathway involved in retrograde trans-synaptic signaling Any endocannabinoid signaling pathway that is involved in retrograde trans-synaptic signaling by endocannabinoid. go.json endocannabinoid signalling pathway involved in retrograde trans-synaptic signaling by endocannabinoid http://purl.obolibrary.org/obo/GO_1905197 GO:1905198 biolink:BiologicalProcess manchette assembly The aggregation, arrangement and bonding together of a set of components to form a manchette. go.json manchette formation http://purl.obolibrary.org/obo/GO_1905198 GO:1905199 biolink:BiologicalProcess manchette disassembly The disaggregation of a manchette into its constituent components. go.json http://purl.obolibrary.org/obo/GO_1905199 GO:0090349 biolink:BiologicalProcess negative regulation of cellular organohalogen metabolic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0090349 GO:0090347 biolink:BiologicalProcess regulation of cellular organohalogen metabolic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0090347 GO:0090348 biolink:BiologicalProcess regulation of cellular organofluorine metabolic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0090348 GO:0090341 biolink:BiologicalProcess negative regulation of secretion of lysosomal enzymes Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. go.json http://purl.obolibrary.org/obo/GO_0090341 GO:0016363 biolink:CellularComponent nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane. Wikipedia:Nuclear_matrix go.json nucleoskeleton http://purl.obolibrary.org/obo/GO_0016363 GO:0090342 biolink:BiologicalProcess obsolete regulation of cell aging OBSOLETE. Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. go.json True http://purl.obolibrary.org/obo/GO_0090342 GO:0090340 biolink:BiologicalProcess positive regulation of secretion of lysosomal enzymes Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. go.json http://purl.obolibrary.org/obo/GO_0090340 GO:0090345 biolink:BiologicalProcess cellular organohalogen metabolic process The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0090345 GO:0016360 biolink:BiologicalProcess sensory organ precursor cell fate determination The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json sense organ precursor cell fate determination http://purl.obolibrary.org/obo/GO_0016360 GO:0090346 biolink:BiologicalProcess cellular organofluorine metabolic process The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0090346 GO:0090343 biolink:BiologicalProcess obsolete positive regulation of cell aging OBSOLETE. Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. go.json True http://purl.obolibrary.org/obo/GO_0090343 GO:0016361 biolink:MolecularActivity activin receptor activity, type I Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. go.json type I activin receptor activity http://purl.obolibrary.org/obo/GO_0016361 GO:0016362 biolink:MolecularActivity activin receptor activity, type II Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. Reactome:R-HSA-201443 go.json type II activin receptor activity http://purl.obolibrary.org/obo/GO_0016362 GO:0090344 biolink:BiologicalProcess obsolete negative regulation of cell aging OBSOLETE. Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. go.json True http://purl.obolibrary.org/obo/GO_0090344 GO:0031999 biolink:BiologicalProcess negative regulation of fatty acid beta-oxidation Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation. go.json down regulation of fatty acid beta-oxidation|down-regulation of fatty acid beta-oxidation|downregulation of fatty acid beta-oxidation|inhibition of fatty acid beta-oxidation http://purl.obolibrary.org/obo/GO_0031999 GO:0031997 biolink:MolecularActivity obsolete N-terminal myristoylation domain binding OBSOLETE. Binding to the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin. go.json True http://purl.obolibrary.org/obo/GO_0031997 GO:0031998 biolink:BiologicalProcess regulation of fatty acid beta-oxidation Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. go.json http://purl.obolibrary.org/obo/GO_0031998 GO:0031995 biolink:MolecularActivity insulin-like growth factor II binding Binding to insulin-like growth factor II. go.json IGF-II binding http://purl.obolibrary.org/obo/GO_0031995 goslim_chembl GO:0031996 biolink:MolecularActivity thioesterase binding Binding to a thioesterase. go.json thiolesterase binding http://purl.obolibrary.org/obo/GO_0031996 GO:0090358 biolink:BiologicalProcess positive regulation of tryptophan metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. go.json positive regulation of tryptophan metabolism http://purl.obolibrary.org/obo/GO_0090358 GO:0090359 biolink:BiologicalProcess negative regulation of abscisic acid biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. go.json negative regulation of abscisic acid biosynthesis http://purl.obolibrary.org/obo/GO_0090359 GO:0090352 biolink:BiologicalProcess regulation of nitrate assimilation Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances. go.json http://purl.obolibrary.org/obo/GO_0090352 GO:0031993 biolink:MolecularActivity light transducer activity Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell. go.json http://purl.obolibrary.org/obo/GO_0031993 GO:0090353 biolink:MolecularActivity polygalacturonase inhibitor activity Binds to and stops, prevents or reduces the activity of polygalacturonase. go.json http://purl.obolibrary.org/obo/GO_0090353 GO:0031994 biolink:MolecularActivity insulin-like growth factor I binding Binding to insulin-like growth factor I. go.json IGF-I binding http://purl.obolibrary.org/obo/GO_0031994 goslim_chembl GO:0031991 biolink:BiologicalProcess regulation of actomyosin contractile ring contraction Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle. go.json regulation of actomyosin contractile ring constriction|regulation of contractile ring contraction involved in cell cycle cytokinesis|regulation of contractile ring contraction involved in cytokinesis during cell cycle http://purl.obolibrary.org/obo/GO_0031991 GO:0090350 biolink:BiologicalProcess negative regulation of cellular organofluorine metabolic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0090350 GO:0090351 biolink:BiologicalProcess seedling development The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge. PO:0008037 go.json http://purl.obolibrary.org/obo/GO_0090351 GO:0031992 biolink:MolecularActivity energy transducer activity The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. go.json light harvesting activity|photon capture http://purl.obolibrary.org/obo/GO_0031992 goslim_pir GO:0090356 biolink:BiologicalProcess negative regulation of auxin metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth. go.json negative regulation of auxin metabolism http://purl.obolibrary.org/obo/GO_0090356 GO:0090357 biolink:BiologicalProcess regulation of tryptophan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. go.json regulation of tryptophan metabolism http://purl.obolibrary.org/obo/GO_0090357 GO:0031990 biolink:BiologicalProcess mRNA export from nucleus in response to heat stress The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export. go.json mRNA export from cell nucleus during heat stress|mRNA export from nucleus during heat stress http://purl.obolibrary.org/obo/GO_0031990 GO:0090354 biolink:BiologicalProcess regulation of auxin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth. go.json regulation of auxin metabolism http://purl.obolibrary.org/obo/GO_0090354 GO:0090355 biolink:BiologicalProcess positive regulation of auxin metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth. go.json positive regulation of auxin metabolism http://purl.obolibrary.org/obo/GO_0090355 GO:2000508 biolink:BiologicalProcess regulation of dendritic cell chemotaxis Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000508 GO:2000509 biolink:BiologicalProcess negative regulation of dendritic cell chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000509 GO:2000500 biolink:BiologicalProcess obsolete positive regulation of induction of apoptosis in response to chemical stimulus OBSOLETE. Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus. go.json positive regulation of induction of apoptosis in response to chemical stimulus|positive regulation of induction of apoptosis in response to chemical substance True http://purl.obolibrary.org/obo/GO_2000500 GO:2000501 biolink:BiologicalProcess regulation of natural killer cell chemotaxis Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000501 GO:2000502 biolink:BiologicalProcess negative regulation of natural killer cell chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000502 GO:2000503 biolink:BiologicalProcess positive regulation of natural killer cell chemotaxis Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000503 GO:2000504 biolink:BiologicalProcess positive regulation of blood vessel remodeling Any process that activates or increases the frequency, rate or extent of blood vessel remodeling. go.json positive regulation of blood vessel remodelling http://purl.obolibrary.org/obo/GO_2000504 GO:2000505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000505 GO:2000506 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000506 GO:2000507 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000507 GO:2000519 biolink:BiologicalProcess positive regulation of T-helper 1 cell activation Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation. go.json positive regulation of Th1 cell activation http://purl.obolibrary.org/obo/GO_2000519 GO:2000511 biolink:BiologicalProcess regulation of granzyme A production Any process that modulates the frequency, rate or extent of granzyme A production. go.json http://purl.obolibrary.org/obo/GO_2000511 GO:2000512 biolink:BiologicalProcess negative regulation of granzyme A production Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production. go.json http://purl.obolibrary.org/obo/GO_2000512 GO:2000513 biolink:BiologicalProcess positive regulation of granzyme A production Any process that activates or increases the frequency, rate or extent of granzyme A production. go.json http://purl.obolibrary.org/obo/GO_2000513 GO:2000514 biolink:BiologicalProcess regulation of CD4-positive, alpha-beta T cell activation Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. go.json http://purl.obolibrary.org/obo/GO_2000514 GO:2000515 biolink:BiologicalProcess negative regulation of CD4-positive, alpha-beta T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. go.json http://purl.obolibrary.org/obo/GO_2000515 GO:2000516 biolink:BiologicalProcess positive regulation of CD4-positive, alpha-beta T cell activation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. go.json http://purl.obolibrary.org/obo/GO_2000516 GO:2000517 biolink:BiologicalProcess regulation of T-helper 1 cell activation Any process that modulates the frequency, rate or extent of T-helper 1 cell activation. go.json regulation of Th1 cell activation http://purl.obolibrary.org/obo/GO_2000517 GO:2000518 biolink:BiologicalProcess negative regulation of T-helper 1 cell activation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation. go.json negative regulation of Th1 cell activation http://purl.obolibrary.org/obo/GO_2000518 GO:2000510 biolink:BiologicalProcess positive regulation of dendritic cell chemotaxis Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000510 GO:2000522 biolink:BiologicalProcess positive regulation of immunological synapse formation Any process that activates or increases the frequency, rate or extent of immunological synapse formation. go.json positive regulation of formation of immunological synapse http://purl.obolibrary.org/obo/GO_2000522 GO:2000523 biolink:BiologicalProcess regulation of T cell costimulation Any process that modulates the frequency, rate or extent of T cell costimulation. go.json regulation of T cell co-stimulation|regulation of T lymphocyte costimulation|regulation of T-cell co-stimulation|regulation of T-cell costimulation|regulation of T-lymphocyte costimulation http://purl.obolibrary.org/obo/GO_2000523 GO:2000524 biolink:BiologicalProcess negative regulation of T cell costimulation Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation. go.json negative regulation of T cell co-stimulation|negative regulation of T lymphocyte costimulation|negative regulation of T-cell co-stimulation|negative regulation of T-cell costimulation|negative regulation of T-lymphocyte costimulation http://purl.obolibrary.org/obo/GO_2000524 GO:2000525 biolink:BiologicalProcess positive regulation of T cell costimulation Any process that activates or increases the frequency, rate or extent of T cell costimulation. go.json positive regulation of T cell co-stimulation|positive regulation of T lymphocyte costimulation|positive regulation of T-cell co-stimulation|positive regulation of T-cell costimulation|positive regulation of T-lymphocyte costimulation http://purl.obolibrary.org/obo/GO_2000525 GO:2000526 biolink:BiologicalProcess positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation. go.json positive regulation of glycoprotein biosynthetic process of formation of immunological synapse|positive regulation of glycoprotein biosynthetic process of immunological synapse formation http://purl.obolibrary.org/obo/GO_2000526 GO:2000527 biolink:BiologicalProcess regulation of myeloid dendritic cell chemotaxis Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000527 GO:2000528 biolink:BiologicalProcess negative regulation of myeloid dendritic cell chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000528 GO:2000529 biolink:BiologicalProcess positive regulation of myeloid dendritic cell chemotaxis Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000529 GO:2000520 biolink:BiologicalProcess regulation of immunological synapse formation Any process that modulates the frequency, rate or extent of immunological synapse formation. go.json regulation of formation of immunological synapse http://purl.obolibrary.org/obo/GO_2000520 GO:2000521 biolink:BiologicalProcess negative regulation of immunological synapse formation Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation. go.json negative regulation of formation of immunological synapse http://purl.obolibrary.org/obo/GO_2000521 GO:2000533 biolink:BiologicalProcess negative regulation of renal albumin absorption Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption. go.json http://purl.obolibrary.org/obo/GO_2000533 GO:2000534 biolink:BiologicalProcess positive regulation of renal albumin absorption Any process that activates or increases the frequency, rate or extent of renal albumin absorption. go.json http://purl.obolibrary.org/obo/GO_2000534 GO:2000535 biolink:BiologicalProcess regulation of entry of bacterium into host cell Any process that modulates the frequency, rate or extent of entry of bacterium into host cell. go.json regulation of bacterial entry into host cell|regulation of invasion of bacteria into host cell http://purl.obolibrary.org/obo/GO_2000535 GO:2000536 biolink:BiologicalProcess negative regulation of entry of bacterium into host cell Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell. go.json negative regulation of bacterial entry into host cell|negative regulation of invasion of bacteria into host cell http://purl.obolibrary.org/obo/GO_2000536 GO:2000537 biolink:BiologicalProcess regulation of B cell chemotaxis Any process that modulates the frequency, rate or extent of B cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000537 GO:2000538 biolink:BiologicalProcess positive regulation of B cell chemotaxis Any process that activates or increases the frequency, rate or extent of B cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000538 GO:2000539 biolink:BiologicalProcess regulation of protein geranylgeranylation Any process that modulates the frequency, rate or extent of protein geranylgeranylation. go.json regulation of C-terminal protein geranylgeranylation|regulation of protein amino acid geranylgeranylation http://purl.obolibrary.org/obo/GO_2000539 GO:2000530 biolink:BiologicalProcess obsolete positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus. go.json positive regulation of regulation of insulin secretion in response to glucose|positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus True http://purl.obolibrary.org/obo/GO_2000530 GO:2000531 biolink:BiologicalProcess obsolete regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_2000531 GO:2000532 biolink:BiologicalProcess regulation of renal albumin absorption Any process that modulates the frequency, rate or extent of renal albumin absorption. go.json http://purl.obolibrary.org/obo/GO_2000532 GO:1905100 biolink:BiologicalProcess regulation of apoptosome assembly Any process that modulates the frequency, rate or extent of apoptosome assembly. go.json regulation of apoptosome formation http://purl.obolibrary.org/obo/GO_1905100 GO:1905101 biolink:BiologicalProcess negative regulation of apoptosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly. go.json down regulation of apoptosome assembly|down regulation of apoptosome formation|down-regulation of apoptosome assembly|down-regulation of apoptosome formation|downregulation of apoptosome assembly|downregulation of apoptosome formation|inhibition of apoptosome assembly|inhibition of apoptosome formation|negative regulation of apoptosome formation http://purl.obolibrary.org/obo/GO_1905101 GO:1905102 biolink:BiologicalProcess positive regulation of apoptosome assembly Any process that activates or increases the frequency, rate or extent of apoptosome assembly. go.json activation of apoptosome assembly|activation of apoptosome formation|positive regulation of apoptosome formation|up regulation of apoptosome assembly|up regulation of apoptosome formation|up-regulation of apoptosome assembly|up-regulation of apoptosome formation|upregulation of apoptosome assembly|upregulation of apoptosome formation http://purl.obolibrary.org/obo/GO_1905102 GO:1905110 biolink:BiologicalProcess negative regulation of pulmonary blood vessel remodeling Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling. go.json down regulation of pulmonary blood vessel remodeling|down-regulation of pulmonary blood vessel remodeling|downregulation of pulmonary blood vessel remodeling|inhibition of pulmonary blood vessel remodeling|negative regulation of pulmonary blood vessel remodelling http://purl.obolibrary.org/obo/GO_1905110 GO:1905111 biolink:BiologicalProcess positive regulation of pulmonary blood vessel remodeling Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling. go.json activation of pulmonary blood vessel remodeling|positive regulation of pulmonary blood vessel remodelling|up regulation of pulmonary blood vessel remodeling|up-regulation of pulmonary blood vessel remodeling|upregulation of pulmonary blood vessel remodeling http://purl.obolibrary.org/obo/GO_1905111 GO:1905112 biolink:BiologicalProcess obsolete regulation of centromere clustering at the mitotic nuclear envelope OBSOLETE. Any process that modulates the frequency, rate or extent of centromere clustering at the nuclear envelope. go.json regulation of centromere clustering at the nuclear periphery|regulation of centromere-SPB clustering|regulation of kinetochore clustering at SPB|regulation of kinetochore clustering at spindle pole body|regulation of kinetochore clustering at the old mitotic spindle pole body|regulation of kinetochore localization at spindle pole body|regulation of rabl configuration True http://purl.obolibrary.org/obo/GO_1905112 GO:1905113 biolink:BiologicalProcess obsolete positive regulation of centromere clustering at the mitotic nuclear envelope OBSOLETE. Any process that activates or increases the frequency, rate or extent of centromere clustering at the nuclear envelope. go.json activation of centromere clustering at the nuclear envelope|activation of centromere clustering at the nuclear periphery|activation of centromere-SPB clustering|activation of kinetochore clustering at SPB|activation of kinetochore clustering at spindle pole body|activation of kinetochore clustering at the old mitotic spindle pole body|activation of kinetochore localization at spindle pole body|activation of rabl configuration|positive regulation of centromere clustering at the nuclear periphery|positive regulation of centromere-SPB clustering|positive regulation of kinetochore clustering at SPB|positive regulation of kinetochore clustering at spindle pole body|positive regulation of kinetochore clustering at the old mitotic spindle pole body|positive regulation of kinetochore localization at spindle pole body|positive regulation of rabl configuration|up regulation of centromere clustering at the nuclear envelope|up regulation of centromere clustering at the nuclear periphery|up regulation of centromere-SPB clustering|up regulation of kinetochore clustering at SPB|up regulation of kinetochore clustering at spindle pole body|up regulation of kinetochore clustering at the old mitotic spindle pole body|up regulation of kinetochore localization at spindle pole body|up regulation of rabl configuration|up-regulation of centromere clustering at the nuclear envelope|up-regulation of centromere clustering at the nuclear periphery|up-regulation of centromere-SPB clustering|up-regulation of kinetochore clustering at SPB|up-regulation of kinetochore clustering at spindle pole body|up-regulation of kinetochore clustering at the old mitotic spindle pole body|up-regulation of kinetochore localization at spindle pole body|up-regulation of rabl configuration|upregulation of centromere clustering at the nuclear envelope|upregulation of centromere clustering at the nuclear periphery|upregulation of centromere-SPB clustering|upregulation of kinetochore clustering at SPB|upregulation of kinetochore clustering at spindle pole body|upregulation of kinetochore clustering at the old mitotic spindle pole body|upregulation of kinetochore localization at spindle pole body|upregulation of rabl configuration True http://purl.obolibrary.org/obo/GO_1905113 GO:1905103 biolink:CellularComponent obsolete integral component of lysosomal membrane OBSOLETE. The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral component of lysosome membrane|integral to lysosomal membrane True http://purl.obolibrary.org/obo/GO_1905103 GO:1905104 biolink:BiologicalProcess obsolete response to ouabain OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus. go.json True http://purl.obolibrary.org/obo/GO_1905104 GO:1905105 biolink:BiologicalProcess obsolete cellular response to ouabain OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus. go.json True http://purl.obolibrary.org/obo/GO_1905105 GO:1905106 biolink:BiologicalProcess obsolete response to Dizocilpine OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus. go.json True http://purl.obolibrary.org/obo/GO_1905106 GO:1905107 biolink:BiologicalProcess obsolete cellular response to Dizocilpine OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus. go.json True http://purl.obolibrary.org/obo/GO_1905107 GO:1905108 biolink:MolecularActivity guanosine binding Binding to guanosine. go.json http://purl.obolibrary.org/obo/GO_1905108 GO:1905109 biolink:BiologicalProcess regulation of pulmonary blood vessel remodeling Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling. go.json regulation of pulmonary blood vessel remodelling http://purl.obolibrary.org/obo/GO_1905109 GO:1905120 biolink:BiologicalProcess cellular response to haloperidol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. go.json http://purl.obolibrary.org/obo/GO_1905120 gocheck_do_not_manually_annotate GO:1905121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905121 GO:1905122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905122 GO:1905123 biolink:BiologicalProcess regulation of glucosylceramidase activity Any process that modulates the frequency, rate or extent of glucosylceramidase activity. go.json regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|regulation of GCase activity|regulation of GlcCer-beta-glucosidase activity|regulation of acid beta-glucosidase activity|regulation of beta-D-glucocerebrosidase activity|regulation of beta-glucocerebrosidase activity|regulation of beta-glucosylceramidase activity|regulation of ceramide glucosidase activity|regulation of glucocerebrosidase activity|regulation of glucosphingosine glucosylhydrolase activity|regulation of glucosylcerebrosidase activity|regulation of glucosylsphingosine beta-D-glucosidase activity|regulation of glucosylsphingosine beta-glucosidase activity|regulation of psychosine hydrolase activity http://purl.obolibrary.org/obo/GO_1905123 gocheck_do_not_annotate GO:1905124 biolink:BiologicalProcess negative regulation of glucosylceramidase activity Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity. go.json down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|down regulation of GlcCer-beta-glucosidase activity|down regulation of acid beta-glucosidase activity|down regulation of beta-D-glucocerebrosidase activity|down regulation of beta-glucocerebrosidase activity|down regulation of beta-glucosylceramidase activity|down regulation of ceramide glucosidase activity|down regulation of glucocerebrosidase activity|down regulation of glucosphingosine glucosylhydrolase activity|down regulation of glucosylceramidase activity|down regulation of glucosylcerebrosidase activity|down regulation of glucosylsphingosine beta-D-glucosidase activity|down regulation of glucosylsphingosine beta-glucosidase activity|down regulation of psychosine hydrolase activity|down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|down-regulation of GlcCer-beta-glucosidase activity|down-regulation of acid beta-glucosidase activity|down-regulation of beta-D-glucocerebrosidase activity|down-regulation of beta-glucocerebrosidase activity|down-regulation of beta-glucosylceramidase activity|down-regulation of ceramide glucosidase activity|down-regulation of glucocerebrosidase activity|down-regulation of glucosphingosine glucosylhydrolase activity|down-regulation of glucosylceramidase activity|down-regulation of glucosylcerebrosidase activity|down-regulation of glucosylsphingosine beta-D-glucosidase activity|down-regulation of glucosylsphingosine beta-glucosidase activity|down-regulation of psychosine hydrolase activity|downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|downregulation of GlcCer-beta-glucosidase activity|downregulation of acid beta-glucosidase activity|downregulation of beta-D-glucocerebrosidase activity|downregulation of beta-glucocerebrosidase activity|downregulation of beta-glucosylceramidase activity|downregulation of ceramide glucosidase activity|downregulation of glucocerebrosidase activity|downregulation of glucosphingosine glucosylhydrolase activity|downregulation of glucosylceramidase activity|downregulation of glucosylcerebrosidase activity|downregulation of glucosylsphingosine beta-D-glucosidase activity|downregulation of glucosylsphingosine beta-glucosidase activity|downregulation of psychosine hydrolase activity|inhibition of D-glucosyl-N-acylsphingosine glucohydrolase activity|inhibition of GlcCer-beta-glucosidase activity|inhibition of acid beta-glucosidase activity|inhibition of beta-D-glucocerebrosidase activity|inhibition of beta-glucocerebrosidase activity|inhibition of beta-glucosylceramidase activity|inhibition of ceramide glucosidase activity|inhibition of glucocerebrosidase activity|inhibition of glucosphingosine glucosylhydrolase activity|inhibition of glucosylceramidase activity|inhibition of glucosylcerebrosidase activity|inhibition of glucosylsphingosine beta-D-glucosidase activity|inhibition of glucosylsphingosine beta-glucosidase activity|inhibition of psychosine hydrolase activity|negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity|negative regulation of GCase activity|negative regulation of GlcCer-beta-glucosidase activity|negative regulation of acid beta-glucosidase activity|negative regulation of beta-D-glucocerebrosidase activity|negative regulation of beta-glucocerebrosidase activity|negative regulation of beta-glucosylceramidase activity|negative regulation of ceramide glucosidase activity|negative regulation of glucocerebrosidase activity|negative regulation of glucosphingosine glucosylhydrolase activity|negative regulation of glucosylcerebrosidase activity|negative regulation of glucosylsphingosine beta-D-glucosidase activity|negative regulation of glucosylsphingosine beta-glucosidase activity|negative regulation of psychosine hydrolase activity http://purl.obolibrary.org/obo/GO_1905124 gocheck_do_not_annotate GO:1905114 biolink:BiologicalProcess obsolete cell surface receptor signaling pathway involved in cell-cell signaling OBSOLETE. Any cell surface receptor signaling pathway that is involved in cell-cell signaling. go.json cell surface receptor linked signal transduction involved in cell-cell signaling|cell surface receptor linked signal transduction involved in cell-cell signalling|cell surface receptor linked signaling pathway involved in cell-cell signaling|cell surface receptor linked signaling pathway involved in cell-cell signalling|cell surface receptor linked signalling pathway involved in cell-cell signaling|cell surface receptor linked signalling pathway involved in cell-cell signalling|cell surface receptor signaling pathway involved in cell-cell signalling True http://purl.obolibrary.org/obo/GO_1905114 GO:1905115 biolink:BiologicalProcess regulation of lateral attachment of mitotic spindle microtubules to kinetochore Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore. go.json http://purl.obolibrary.org/obo/GO_1905115 GO:1905116 biolink:BiologicalProcess positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore. go.json activation of lateral attachment of mitotic spindle microtubules to kinetochore|up regulation of lateral attachment of mitotic spindle microtubules to kinetochore|up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore|upregulation of lateral attachment of mitotic spindle microtubules to kinetochore http://purl.obolibrary.org/obo/GO_1905116 GO:1905117 biolink:BiologicalProcess regulation of ribonucleoside-diphosphate reductase activity Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity. go.json regulation of RNR|regulation of adenosylcobalamin-dependent ribonucleotide reductase activity|regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity|regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity|regulation of class I ribonucleotide reductase activity|regulation of class II ribonucleoside-diphosphate reductase activity|regulation of class II ribonucleotide reductase activity|regulation of class III ribonucleotide reductase activity|regulation of nucleoside diphosphate reductase activity|regulation of purine/pyrimidine nucleoside diphosphate reduction|regulation of ribonucleoside 5'-diphosphate reductase activity|regulation of ribonucleotide diphosphate reductase activity|regulation of ribonucleotide reductase activity http://purl.obolibrary.org/obo/GO_1905117 gocheck_do_not_annotate GO:1905118 biolink:BiologicalProcess positive regulation of ribonucleoside-diphosphate reductase activity Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity. go.json activation of RNR|activation of adenosylcobalamin-dependent ribonucleotide reductase activity|activation of aerobic non-heme iron-dependent ribonucleotide reductase activity|activation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity|activation of class I ribonucleotide reductase activity|activation of class II ribonucleoside-diphosphate reductase activity|activation of class II ribonucleotide reductase activity|activation of class III ribonucleotide reductase activity|activation of nucleoside diphosphate reductase activity|activation of purine/pyrimidine nucleoside diphosphate reduction|activation of ribonucleoside 5'-diphosphate reductase activity|activation of ribonucleoside-diphosphate reductase activity|activation of ribonucleotide diphosphate reductase activity|positive regulation of RNR|positive regulation of adenosylcobalamin-dependent ribonucleotide reductase activity|positive regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity|positive regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity|positive regulation of class I ribonucleotide reductase activity|positive regulation of class II ribonucleoside-diphosphate reductase activity|positive regulation of class II ribonucleotide reductase activity|positive regulation of class III ribonucleotide reductase activity|positive regulation of nucleoside diphosphate reductase activity|positive regulation of purine/pyrimidine nucleoside diphosphate reduction|positive regulation of ribonucleoside 5'-diphosphate reductase activity|positive regulation of ribonucleotide diphosphate reductase activity|up regulation of RNR|up regulation of adenosylcobalamin-dependent ribonucleotide reductase activity|up regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity|up regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity|up regulation of class I ribonucleotide reductase activity|up regulation of class II ribonucleoside-diphosphate reductase activity|up regulation of class II ribonucleotide reductase activity|up regulation of class III ribonucleotide reductase activity|up regulation of nucleoside diphosphate reductase activity|up regulation of purine/pyrimidine nucleoside diphosphate reduction|up regulation of ribonucleoside 5'-diphosphate reductase activity|up regulation of ribonucleoside-diphosphate reductase activity|up regulation of ribonucleotide diphosphate reductase activity|up-regulation of RNR|up-regulation of adenosylcobalamin-dependent ribonucleotide reductase activity|up-regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity|up-regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity|up-regulation of class I ribonucleotide reductase activity|up-regulation of class II ribonucleoside-diphosphate reductase activity|up-regulation of class II ribonucleotide reductase activity|up-regulation of class III ribonucleotide reductase activity|up-regulation of nucleoside diphosphate reductase activity|up-regulation of purine/pyrimidine nucleoside diphosphate reduction|up-regulation of ribonucleoside 5'-diphosphate reductase activity|up-regulation of ribonucleoside-diphosphate reductase activity|up-regulation of ribonucleotide diphosphate reductase activity|upregulation of RNR|upregulation of adenosylcobalamin-dependent ribonucleotide reductase activity|upregulation of aerobic non-heme iron-dependent ribonucleotide reductase activity|upregulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity|upregulation of class I ribonucleotide reductase activity|upregulation of class II ribonucleoside-diphosphate reductase activity|upregulation of class II ribonucleotide reductase activity|upregulation of class III ribonucleotide reductase activity|upregulation of nucleoside diphosphate reductase activity|upregulation of purine/pyrimidine nucleoside diphosphate reduction|upregulation of ribonucleoside 5'-diphosphate reductase activity|upregulation of ribonucleoside-diphosphate reductase activity|upregulation of ribonucleotide diphosphate reductase activity http://purl.obolibrary.org/obo/GO_1905118 gocheck_do_not_annotate GO:1905119 biolink:BiologicalProcess response to haloperidol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. go.json http://purl.obolibrary.org/obo/GO_1905119 gocheck_do_not_manually_annotate GO:0031902 biolink:CellularComponent late endosome membrane The lipid bilayer surrounding a late endosome. go.json http://purl.obolibrary.org/obo/GO_0031902 GO:0006946 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006946 GO:0031903 biolink:CellularComponent microbody membrane The lipid bilayer surrounding a microbody. go.json http://purl.obolibrary.org/obo/GO_0031903 GO:0006947 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006947 GO:0031900 biolink:CellularComponent chromoplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope. go.json http://purl.obolibrary.org/obo/GO_0031900 GO:0006944 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006944 GO:0031901 biolink:CellularComponent early endosome membrane The lipid bilayer surrounding an early endosome. go.json http://purl.obolibrary.org/obo/GO_0031901 GO:0006945 biolink:BiologicalProcess obsolete nuclear fusion during karyogamy OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process. go.json nuclear fusion during karyogamy True http://purl.obolibrary.org/obo/GO_0006945 GO:0006942 biolink:BiologicalProcess regulation of striated muscle contraction Any process that modulates the frequency, rate or extent of striated muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0006942 GO:0006943 biolink:BiologicalProcess obsolete chemi-mechanical coupling OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle). go.json chemi-mechanical coupling|mechanochemical coupling True http://purl.obolibrary.org/obo/GO_0006943 GO:0006940 biolink:BiologicalProcess regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0006940 GO:0006941 biolink:BiologicalProcess striated muscle contraction A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. go.json sarcomeric muscle contraction http://purl.obolibrary.org/obo/GO_0006941 GO:2000588 biolink:BiologicalProcess positive regulation of platelet-derived growth factor receptor-beta signaling pathway Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. go.json positive regulation of PDGF receptor-beta signaling pathway|positive regulation of PDGFR-beta signaling pathway|positive regulation of betaPDGF receptor signaling pathway|positive regulation of platelet-derived growth factor receptor-beta signalling pathway http://purl.obolibrary.org/obo/GO_2000588 GO:2000589 biolink:BiologicalProcess regulation of metanephric mesenchymal cell migration Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration. go.json regulation of metanephric mesenchyme chemotaxis http://purl.obolibrary.org/obo/GO_2000589 GO:0031908 biolink:CellularComponent glyoxysomal lumen The volume enclosed by the membranes of a glyoxysome. go.json http://purl.obolibrary.org/obo/GO_0031908 GO:0031909 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031909 GO:0031906 biolink:CellularComponent late endosome lumen The volume enclosed by the membrane of a late endosome. go.json http://purl.obolibrary.org/obo/GO_0031906 GO:0031907 biolink:CellularComponent microbody lumen The volume enclosed by the membranes of a microbody. go.json http://purl.obolibrary.org/obo/GO_0031907 GO:0031904 biolink:CellularComponent endosome lumen The volume enclosed by the membrane of an endosome. NIF_Subcellular:sao1547508851 go.json http://purl.obolibrary.org/obo/GO_0031904 GO:0031905 biolink:CellularComponent early endosome lumen The volume enclosed by the membrane of an early endosome. go.json http://purl.obolibrary.org/obo/GO_0031905 GO:2000580 biolink:BiologicalProcess obsolete regulation of microtubule motor activity, plus-end-directed OBSOLETE. Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed. go.json regulation of ATP-dependent microtubule motor activity, plus-end-directed|regulation of kinesin ATP phosphohydrolase (plus-end-directed)|regulation of kinesin activity|regulation of plus-end-directed kinesin ATPase activity|regulation of plus-end-directed microtubule motor activity True http://purl.obolibrary.org/obo/GO_2000580 GO:2000581 biolink:BiologicalProcess obsolete negative regulation of microtubule motor activity, plus-end-directed OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed. go.json negative regulation of ATP-dependent microtubule motor activity, plus-end-directed|negative regulation of kinesin ATP phosphohydrolase (plus-end-directed)|negative regulation of kinesin activity|negative regulation of plus-end-directed kinesin ATPase activity|negative regulation of plus-end-directed microtubule motor activity True http://purl.obolibrary.org/obo/GO_2000581 GO:2000582 biolink:BiologicalProcess obsolete positive regulation of microtubule motor activity, plus-end-directed OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed. go.json positive regulation of ATP-dependent microtubule motor activity, plus-end-directed|positive regulation of kinesin ATP phosphohydrolase (plus-end-directed)|positive regulation of kinesin activity|positive regulation of plus-end-directed kinesin ATPase activity|positive regulation of plus-end-directed microtubule motor activity True http://purl.obolibrary.org/obo/GO_2000582 GO:2000583 biolink:BiologicalProcess regulation of platelet-derived growth factor receptor-alpha signaling pathway Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. go.json regulation of PDGF receptor-alpha signaling pathway|regulation of PDGFR-alpha signaling pathway|regulation of alphaPDGF receptor signaling pathway|regulation of platelet-derived growth factor receptor-alpha signalling pathway http://purl.obolibrary.org/obo/GO_2000583 GO:2000584 biolink:BiologicalProcess negative regulation of platelet-derived growth factor receptor-alpha signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. go.json negative regulation of PDGF receptor-alpha signaling pathway|negative regulation of PDGFR-alpha signaling pathway|negative regulation of alphaPDGF receptor signaling pathway|negative regulation of platelet-derived growth factor receptor-alpha signalling pathway http://purl.obolibrary.org/obo/GO_2000584 GO:2000585 biolink:BiologicalProcess positive regulation of platelet-derived growth factor receptor-alpha signaling pathway Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. go.json positive regulation of PDGF receptor-alpha signaling pathway|positive regulation of PDGFR-alpha signaling pathway|positive regulation of alphaPDGF receptor signaling pathway|positive regulation of platelet-derived growth factor receptor-alpha signalling pathway http://purl.obolibrary.org/obo/GO_2000585 GO:2000586 biolink:BiologicalProcess regulation of platelet-derived growth factor receptor-beta signaling pathway Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. go.json regulation of PDGF receptor-beta signaling pathway|regulation of PDGFR-beta signaling pathway|regulation of betaPDGF receptor signaling pathway|regulation of platelet-derived growth factor receptor-beta signalling pathway http://purl.obolibrary.org/obo/GO_2000586 GO:2000587 biolink:BiologicalProcess negative regulation of platelet-derived growth factor receptor-beta signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. go.json negative regulation of PDGF receptor-beta signaling pathway|negative regulation of PDGFR-beta signaling pathway|negative regulation of betaPDGF receptor signaling pathway|negative regulation of platelet-derived growth factor receptor-beta signalling pathway http://purl.obolibrary.org/obo/GO_2000587 GO:0006948 biolink:BiologicalProcess induction by virus of host cell-cell fusion The process of syncytia-forming cell-cell fusion, caused by a virus. go.json induction by virus of cell-cell fusion in host|viral-induced cell-cell fusion|viral-induced host cell-cell fusion|viral-induced membrane fusion http://purl.obolibrary.org/obo/GO_0006948 GO:0006949 biolink:BiologicalProcess syncytium formation The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. go.json http://purl.obolibrary.org/obo/GO_0006949 goslim_pir GO:0006957 biolink:BiologicalProcess complement activation, alternative pathway Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. go.json complement cascade, alternative pathway http://purl.obolibrary.org/obo/GO_0006957 GO:0006958 biolink:BiologicalProcess complement activation, classical pathway Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. go.json complement cascade, classical pathway http://purl.obolibrary.org/obo/GO_0006958 GO:0006955 biolink:BiologicalProcess immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. go.json http://purl.obolibrary.org/obo/GO_0006955 goslim_drosophila GO:0006956 biolink:BiologicalProcess complement activation Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. go.json complement activity|complement cascade|complement response http://purl.obolibrary.org/obo/GO_0006956 GO:0006953 biolink:BiologicalProcess acute-phase response An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. go.json http://purl.obolibrary.org/obo/GO_0006953 GO:0006954 biolink:BiologicalProcess inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. Wikipedia:Inflammation go.json inflammation http://purl.obolibrary.org/obo/GO_0006954 goslim_generic GO:0006951 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006951 GO:0006952 biolink:BiologicalProcess defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. go.json antimicrobial peptide activity|defence response|defense/immunity protein activity|physiological defense response http://purl.obolibrary.org/obo/GO_0006952 GO:2000599 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000599 GO:0006950 biolink:BiologicalProcess response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json response to abiotic stress|response to biotic stress http://purl.obolibrary.org/obo/GO_0006950 gocheck_do_not_manually_annotate|goslim_candida|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_plant GO:2000591 biolink:BiologicalProcess positive regulation of metanephric mesenchymal cell migration Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration. go.json positive regulation of metanephric mesenchyme chemotaxis http://purl.obolibrary.org/obo/GO_2000591 GO:2000592 biolink:BiologicalProcess regulation of metanephric DCT cell differentiation Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation. go.json regulation of metanephric distal convoluted tubule cell differentiation http://purl.obolibrary.org/obo/GO_2000592 GO:2000593 biolink:BiologicalProcess negative regulation of metanephric DCT cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation. go.json negative regulation of metanephric distal convoluted tubule cell differentiation http://purl.obolibrary.org/obo/GO_2000593 GO:2000594 biolink:BiologicalProcess positive regulation of metanephric DCT cell differentiation Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation. go.json positive regulation of metanephric distal convoluted tubule cell differentiation http://purl.obolibrary.org/obo/GO_2000594 GO:2000595 biolink:BiologicalProcess regulation of optic nerve formation Any process that modulates the frequency, rate or extent of optic nerve formation. go.json regulation of CN II biosynthesis|regulation of CN II formation http://purl.obolibrary.org/obo/GO_2000595 GO:2000596 biolink:BiologicalProcess negative regulation of optic nerve formation Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation. go.json negative regulation of CN II biosynthesis|negative regulation of CN II formation http://purl.obolibrary.org/obo/GO_2000596 GO:2000597 biolink:BiologicalProcess positive regulation of optic nerve formation Any process that activates or increases the frequency, rate or extent of optic nerve formation. go.json positive regulation of CN II biosynthesis|positive regulation of CN II formation http://purl.obolibrary.org/obo/GO_2000597 GO:2000598 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000598 GO:0006959 biolink:BiologicalProcess humoral immune response An immune response mediated through a body fluid. Wikipedia:Humoral_immunity go.json http://purl.obolibrary.org/obo/GO_0006959 GO:2000590 biolink:BiologicalProcess negative regulation of metanephric mesenchymal cell migration Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration. go.json negative regulation of metanephric mesenchyme chemotaxis http://purl.obolibrary.org/obo/GO_2000590 GO:0006924 biolink:BiologicalProcess activation-induced cell death of T cells A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors. go.json AICD|activated T cell apoptosis|activation-induced cell death of T lymphocytes|activation-induced cell death of T-cells|activation-induced cell death of T-lymphocytes|antigen-driven apoptosis http://purl.obolibrary.org/obo/GO_0006924 GO:0006925 biolink:BiologicalProcess inflammatory cell apoptotic process Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. go.json apoptosis of inflammatory cells|inflammatory cell apoptosis|inflammatory cell programmed cell death by apoptosis|killing of inflammatory cells|programmed cell death of inflammatory cells by apoptosis|programmed cell death, inflammatory cells http://purl.obolibrary.org/obo/GO_0006925 GO:0006922 biolink:BiologicalProcess obsolete cleavage of lamin involved in execution phase of apoptosis OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina. go.json cleavage of lamin|cleavage of lamin involved in execution phase of apoptosis True http://purl.obolibrary.org/obo/GO_0006922 GO:0006923 biolink:BiologicalProcess obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures. go.json apoptotic cleavage of cytoskeletal proteins|cleavage of cytoskeletal proteins involved in apoptosis|cleavage of cytoskeletal proteins involved in execution phase of apoptosis True http://purl.obolibrary.org/obo/GO_0006923 GO:0006920 biolink:BiologicalProcess obsolete commitment to apoptosis OBSOLETE. (Was not defined before being made obsolete). go.json commitment to apoptosis True http://purl.obolibrary.org/obo/GO_0006920 GO:0006921 biolink:BiologicalProcess cellular component disassembly involved in execution phase of apoptosis The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. go.json cellular component disassembly involved in apoptosis|cellular component disassembly involved in apoptotic process|disassembly of cell structures http://purl.obolibrary.org/obo/GO_0006921 GO:0006928 biolink:BiologicalProcess obsolete movement of cell or subcellular component OBSOLETE. The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. go.json cell movement|cellular component motion|cellular component movement True http://purl.obolibrary.org/obo/GO_0006928 GO:0006929 biolink:BiologicalProcess substrate-dependent cell migration The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. go.json substrate-bound cell migration http://purl.obolibrary.org/obo/GO_0006929 GO:0006926 biolink:BiologicalProcess obsolete virus-infected cell apoptotic process OBSOLETE. Any apoptotic process in a cell infected with a virus. go.json apoptosis of virus-infected cells|killing virus-infected cells|programmed cell death of virus-infected cells by apoptosis|programmed cell death, virus-infected cells|virus-infected cell apoptosis|virus-infected cell apoptotic process|virus-infected cell programmed cell death by apoptosis True http://purl.obolibrary.org/obo/GO_0006926 GO:0006927 biolink:BiologicalProcess obsolete transformed cell apoptotic process OBSOLETE. Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm. go.json apoptosis of transformed cells|killing transformed cells|programmed cell death of transformed cells by apoptosis|programmed cell death, transformed cells|transformed cell apoptosis|transformed cell programmed cell death by apoptosis True http://purl.obolibrary.org/obo/GO_0006927 GO:0006935 biolink:BiologicalProcess chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). Wikipedia:Chemotaxis go.json taxis in response to chemical stimulus http://purl.obolibrary.org/obo/GO_0006935 GO:0006936 biolink:BiologicalProcess muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Wikipedia:Muscle_contraction go.json http://purl.obolibrary.org/obo/GO_0006936 goslim_pir GO:0006933 biolink:BiologicalProcess negative regulation of cell adhesion involved in substrate-bound cell migration The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. go.json substrate-bound cell migration, cell release from substrate http://purl.obolibrary.org/obo/GO_0006933 GO:0006934 biolink:BiologicalProcess substrate-bound cell migration, adhesion receptor recycling The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions. go.json http://purl.obolibrary.org/obo/GO_0006934 GO:0006931 biolink:BiologicalProcess substrate-dependent cell migration, cell attachment to substrate The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions. go.json substrate-bound cell migration, cell attachment to substrate http://purl.obolibrary.org/obo/GO_0006931 GO:0006932 biolink:BiologicalProcess substrate-dependent cell migration, cell contraction The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves. go.json substrate-bound cell migration, cell contraction http://purl.obolibrary.org/obo/GO_0006932 GO:0006930 biolink:BiologicalProcess substrate-dependent cell migration, cell extension The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. go.json substrate-bound cell migration, cell extension http://purl.obolibrary.org/obo/GO_0006930 GO:0006939 biolink:BiologicalProcess smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. go.json visceral muscle contraction http://purl.obolibrary.org/obo/GO_0006939 GO:0006937 biolink:BiologicalProcess regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0006937 GO:0006938 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006938 GO:0006902 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006902 GO:0006903 biolink:BiologicalProcess vesicle targeting The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. go.json http://purl.obolibrary.org/obo/GO_0006903 GO:0006900 biolink:BiologicalProcess vesicle budding from membrane The evagination of a membrane, resulting in formation of a vesicle. go.json membrane evagination|nonselective vesicle assembly|single organism membrane budding|single-organism membrane budding|vesicle biosynthesis|vesicle budding|vesicle formation http://purl.obolibrary.org/obo/GO_0006900 GO:0006901 biolink:BiologicalProcess vesicle coating A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. go.json vesicle coat assembly http://purl.obolibrary.org/obo/GO_0006901 GO:2000544 biolink:BiologicalProcess regulation of endothelial cell chemotaxis to fibroblast growth factor Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. go.json http://purl.obolibrary.org/obo/GO_2000544 GO:2000545 biolink:BiologicalProcess negative regulation of endothelial cell chemotaxis to fibroblast growth factor Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. go.json http://purl.obolibrary.org/obo/GO_2000545 GO:2000546 biolink:BiologicalProcess positive regulation of endothelial cell chemotaxis to fibroblast growth factor Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. go.json http://purl.obolibrary.org/obo/GO_2000546 GO:2000547 biolink:BiologicalProcess regulation of dendritic cell dendrite assembly Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. go.json regulation of dendritic extension http://purl.obolibrary.org/obo/GO_2000547 GO:2000548 biolink:BiologicalProcess negative regulation of dendritic cell dendrite assembly Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly. go.json negative regulation of dendritic extension http://purl.obolibrary.org/obo/GO_2000548 GO:2000549 biolink:BiologicalProcess positive regulation of dendritic cell dendrite assembly Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly. go.json positive regulation of dendritic extension http://purl.obolibrary.org/obo/GO_2000549 GO:2000540 biolink:BiologicalProcess negative regulation of protein geranylgeranylation Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation. go.json negative regulation of C-terminal protein geranylgeranylation|negative regulation of protein amino acid geranylgeranylation http://purl.obolibrary.org/obo/GO_2000540 GO:2000541 biolink:BiologicalProcess positive regulation of protein geranylgeranylation Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation. go.json positive regulation of C-terminal protein geranylgeranylation|positive regulation of protein amino acid geranylgeranylation http://purl.obolibrary.org/obo/GO_2000541 GO:2000542 biolink:BiologicalProcess negative regulation of gastrulation Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. go.json http://purl.obolibrary.org/obo/GO_2000542 GO:2000543 biolink:BiologicalProcess positive regulation of gastrulation Any process that activates or increases the frequency, rate or extent of gastrulation. go.json http://purl.obolibrary.org/obo/GO_2000543 GO:0006908 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006908 GO:0006909 biolink:BiologicalProcess phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. Wikipedia:Phagocytosis go.json http://purl.obolibrary.org/obo/GO_0006909 GO:0006906 biolink:BiologicalProcess vesicle fusion Fusion of the membrane of a transport vesicle with its target membrane. go.json http://purl.obolibrary.org/obo/GO_0006906 GO:0006907 biolink:BiologicalProcess pinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. Wikipedia:Pinocytosis go.json clathrin-independent pinocytosis|fluid-phase endocytosis|single-organism pinocytosis http://purl.obolibrary.org/obo/GO_0006907 GO:0006904 biolink:BiologicalProcess vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. go.json vesicle docking during exocytosis http://purl.obolibrary.org/obo/GO_0006904 GO:0006905 biolink:BiologicalProcess obsolete vesicle transport OBSOLETE. (Was not defined before being made obsolete). go.json vesicle transport True http://purl.obolibrary.org/obo/GO_0006905 GO:0006913 biolink:BiologicalProcess nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. go.json nucleocytoplasmic shuttling http://purl.obolibrary.org/obo/GO_0006913 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pombe GO:0006914 biolink:BiologicalProcess autophagy The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation. Wikipedia:Autophagy_(cellular) go.json http://purl.obolibrary.org/obo/GO_0006914 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe GO:0006911 biolink:BiologicalProcess phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. go.json phagosome biosynthesis|phagosome formation http://purl.obolibrary.org/obo/GO_0006911 GO:0006912 biolink:BiologicalProcess obsolete phagosome formation OBSOLETE. (Was not defined before being made obsolete). go.json phagosome formation True http://purl.obolibrary.org/obo/GO_0006912 GO:0006910 biolink:BiologicalProcess phagocytosis, recognition The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. go.json recognition of phagocytosed substance by phagocytic cell http://purl.obolibrary.org/obo/GO_0006910 GO:2000555 biolink:BiologicalProcess negative regulation of T-helper 1 cell cytokine production Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production. go.json negative regulation of Th1 cell cytokine production http://purl.obolibrary.org/obo/GO_2000555 GO:2000556 biolink:BiologicalProcess positive regulation of T-helper 1 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production. go.json positive regulation of Th1 cell cytokine production http://purl.obolibrary.org/obo/GO_2000556 GO:2000557 biolink:BiologicalProcess regulation of immunoglobulin production in mucosal tissue Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue. go.json regulation of antibody production in mucosal tissue http://purl.obolibrary.org/obo/GO_2000557 GO:2000558 biolink:BiologicalProcess positive regulation of immunoglobulin production in mucosal tissue Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue. go.json positive regulation of antibody production in mucosal tissue http://purl.obolibrary.org/obo/GO_2000558 GO:2000559 biolink:BiologicalProcess regulation of CD24 production Any process that modulates the frequency, rate or extent of CD24 biosynthetic process. go.json regulation of CD24 anabolism|regulation of CD24 biosynthesis|regulation of CD24 biosynthetic process|regulation of CD24 formation|regulation of CD24 synthesis http://purl.obolibrary.org/obo/GO_2000559 GO:2000550 biolink:BiologicalProcess negative regulation of B cell chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000550 GO:2000551 biolink:BiologicalProcess regulation of T-helper 2 cell cytokine production Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production. go.json regulation of Th2 cell cytokine production http://purl.obolibrary.org/obo/GO_2000551 GO:2000552 biolink:BiologicalProcess negative regulation of T-helper 2 cell cytokine production Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production. go.json negative regulation of Th2 cell cytokine production http://purl.obolibrary.org/obo/GO_2000552 GO:2000553 biolink:BiologicalProcess positive regulation of T-helper 2 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. go.json positive regulation of Th2 cell cytokine production http://purl.obolibrary.org/obo/GO_2000553 GO:2000554 biolink:BiologicalProcess regulation of T-helper 1 cell cytokine production Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production. go.json regulation of Th1 cell cytokine production http://purl.obolibrary.org/obo/GO_2000554 GO:0006919 biolink:BiologicalProcess activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. go.json activation of caspase activity|activation of metacaspase activity|caspase activation http://purl.obolibrary.org/obo/GO_0006919 gocheck_do_not_annotate GO:0006917 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006917 GO:0006918 biolink:BiologicalProcess obsolete induction of apoptosis by p53 OBSOLETE. (Was not defined before being made obsolete). go.json induction of apoptosis by p53 True http://purl.obolibrary.org/obo/GO_0006918 GO:0006915 biolink:BiologicalProcess apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. Wikipedia:Apoptosis go.json activation of apoptosis|apoptosis|apoptosis activator activity|apoptosis signaling|apoptotic cell death|apoptotic program|apoptotic programmed cell death|caspase-dependent programmed cell death|cell suicide|cellular suicide|commitment to apoptosis|induction of apoptosis|induction of apoptosis by p53|programmed cell death by apoptosis|signaling (initiator) caspase activity|type I programmed cell death http://purl.obolibrary.org/obo/GO_0006915 GO:0006916 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006916 GO:2000566 biolink:BiologicalProcess positive regulation of CD8-positive, alpha-beta T cell proliferation Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000566 GO:2000567 biolink:BiologicalProcess regulation of memory T cell activation Any process that modulates the frequency, rate or extent of memory T cell activation. go.json http://purl.obolibrary.org/obo/GO_2000567 GO:2000568 biolink:BiologicalProcess positive regulation of memory T cell activation Any process that activates or increases the frequency, rate or extent of memory T cell activation. go.json http://purl.obolibrary.org/obo/GO_2000568 GO:2000569 biolink:BiologicalProcess regulation of T-helper 2 cell activation Any process that modulates the frequency, rate or extent of T-helper 2 cell activation. go.json regulation of Th2 cell activation http://purl.obolibrary.org/obo/GO_2000569 GO:2000560 biolink:BiologicalProcess positive regulation of CD24 production Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process. go.json positive regulation of CD24 anabolism|positive regulation of CD24 biosynthesis|positive regulation of CD24 biosynthetic process|positive regulation of CD24 formation|positive regulation of CD24 synthesis http://purl.obolibrary.org/obo/GO_2000560 GO:2000561 biolink:BiologicalProcess regulation of CD4-positive, alpha-beta T cell proliferation Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000561 GO:2000562 biolink:BiologicalProcess negative regulation of CD4-positive, alpha-beta T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000562 GO:2000563 biolink:BiologicalProcess positive regulation of CD4-positive, alpha-beta T cell proliferation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000563 GO:2000564 biolink:BiologicalProcess regulation of CD8-positive, alpha-beta T cell proliferation Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000564 GO:2000565 biolink:BiologicalProcess negative regulation of CD8-positive, alpha-beta T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000565 GO:2000577 biolink:BiologicalProcess obsolete regulation of microtubule motor activity, minus-end-directed OBSOLETE. Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed. go.json regulation of ATP-dependent microtubule motor activity, minus-end-directed|regulation of kinesin ATP phosphohydrolase (minus-end-directed)|regulation of minus-end-directed kinesin ATPase activity|regulation of minus-end-directed microtubule motor activity True http://purl.obolibrary.org/obo/GO_2000577 GO:2000578 biolink:BiologicalProcess obsolete negative regulation of microtubule motor activity, minus-end-directed OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed. go.json negative regulation of ATP-dependent microtubule motor activity, minus-end-directed|negative regulation of kinesin ATP phosphohydrolase (minus-end-directed)|negative regulation of minus-end-directed kinesin ATPase activity|negative regulation of minus-end-directed microtubule motor activity True http://purl.obolibrary.org/obo/GO_2000578 GO:2000579 biolink:BiologicalProcess obsolete positive regulation of microtubule motor activity, minus-end-directed OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed. go.json positive regulation of ATP-dependent microtubule motor activity, minus-end-directed|positive regulation of kinesin ATP phosphohydrolase (minus-end-directed)|positive regulation of minus-end-directed kinesin ATPase activity|positive regulation of minus-end-directed microtubule motor activity True http://purl.obolibrary.org/obo/GO_2000579 GO:2000570 biolink:BiologicalProcess positive regulation of T-helper 2 cell activation Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation. go.json positive regulation of Th2 cell activation http://purl.obolibrary.org/obo/GO_2000570 GO:2000571 biolink:BiologicalProcess regulation of interleukin-4-dependent isotype switching to IgE isotypes Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes. go.json regulation of IL-4-dependent isotype switching to IgE isotypes http://purl.obolibrary.org/obo/GO_2000571 GO:2000572 biolink:BiologicalProcess positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes. go.json positive regulation of IL-4-dependent isotype switching to IgE isotypes http://purl.obolibrary.org/obo/GO_2000572 GO:2000573 biolink:BiologicalProcess positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. go.json positive regulation of DNA anabolism|positive regulation of DNA biosynthesis|positive regulation of DNA formation|positive regulation of DNA synthesis http://purl.obolibrary.org/obo/GO_2000573 GO:2000574 biolink:BiologicalProcess obsolete regulation of microtubule motor activity OBSOLETE. Any process that modulates the frequency, rate or extent of microtubule motor activity. go.json regulation of axonemal motor activity|regulation of dynein|regulation of dynein ATPase activity|regulation of kinesin|regulation of kinesin motor activity|regulation of kinetochore motor activity True http://purl.obolibrary.org/obo/GO_2000574 GO:2000575 biolink:BiologicalProcess obsolete negative regulation of microtubule motor activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity. go.json negative regulation of axonemal motor activity|negative regulation of dynein|negative regulation of dynein ATPase activity|negative regulation of kinesin|negative regulation of kinesin motor activity|negative regulation of kinetochore motor activity True http://purl.obolibrary.org/obo/GO_2000575 GO:2000576 biolink:BiologicalProcess obsolete positive regulation of microtubule motor activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of microtubule motor activity. go.json positive regulation of axonemal motor activity|positive regulation of dynein|positive regulation of dynein ATPase activity|positive regulation of kinesin|positive regulation of kinesin motor activity|positive regulation of kinetochore motor activity True http://purl.obolibrary.org/obo/GO_2000576 GO:0031988 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031988 GO:0031989 biolink:BiologicalProcess bombesin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json bombesin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0031989 GO:1905090 biolink:BiologicalProcess negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization. go.json down regulation of parkin-mediated mitophagy in response to mitochondrial depolarization|down-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization|downregulation of parkin-mediated mitophagy in response to mitochondrial depolarization|inhibition of parkin-mediated mitophagy in response to mitochondrial depolarization|negative regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization|negative regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_1905090 GO:1905091 biolink:BiologicalProcess positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization. go.json activation of parkin-mediated mitophagy in response to mitochondrial depolarization|positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization|positive regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization|up regulation of parkin-mediated mitophagy in response to mitochondrial depolarization|up-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization|upregulation of parkin-mediated mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_1905091 GO:0031986 biolink:CellularComponent proteinoplast A leucoplast in which protein is stored. Wikipedia:Proteinoplast go.json http://purl.obolibrary.org/obo/GO_0031986 GO:0090282 biolink:BiologicalProcess obsolete positive regulation of transcription involved in G2/M transition of mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle. go.json activation of G2/M-specific transcription in the mitotic cell cycle|activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle|activation of transcription involved in G2/M transition of mitotic cell cycle|positive regulation of G2/M-specific transcription in the mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle|up-regulation of G2/M-specific transcription in the mitotic cell cycle|up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle|up-regulation of transcription involved in G2/M transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0090282 GO:0090283 biolink:BiologicalProcess obsolete regulation of protein glycosylation in Golgi OBSOLETE. Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus. go.json regulation of protein amino acid glycosylation in Golgi True http://purl.obolibrary.org/obo/GO_0090283 GO:1905092 biolink:BiologicalProcess response to diosgenin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus. go.json http://purl.obolibrary.org/obo/GO_1905092 GO:0031987 biolink:BiologicalProcess locomotion involved in locomotory behavior Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. go.json locomotion during locomotory behaviour http://purl.obolibrary.org/obo/GO_0031987 GO:0090280 biolink:BiologicalProcess positive regulation of calcium ion import Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. go.json positive regulation of transmembrane calcium influx http://purl.obolibrary.org/obo/GO_0090280 GO:1905093 biolink:BiologicalProcess cellular response to diosgenin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus. go.json http://purl.obolibrary.org/obo/GO_1905093 GO:0031984 biolink:CellularComponent organelle subcompartment A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. go.json suborganelle compartment http://purl.obolibrary.org/obo/GO_0031984 GO:0031985 biolink:CellularComponent Golgi cisterna Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. NIF_Subcellular:sao561419532 go.json Golgi apparatus cisterna|Golgi lamellae http://purl.obolibrary.org/obo/GO_0031985 GO:1905094 biolink:BiologicalProcess regulation of apolipoprotein A-I-mediated signaling pathway Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. go.json regulation of apolipoprotein A-I-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1905094 GO:0090281 biolink:BiologicalProcess negative regulation of calcium ion import Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. go.json negative regulation of transmembrane calcium influx http://purl.obolibrary.org/obo/GO_0090281 GO:1905095 biolink:BiologicalProcess negative regulation of apolipoprotein A-I-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. go.json down regulation of apolipoprotein A-I-mediated signaling pathway|down regulation of apolipoprotein A-I-mediated signalling pathway|down-regulation of apolipoprotein A-I-mediated signaling pathway|down-regulation of apolipoprotein A-I-mediated signalling pathway|downregulation of apolipoprotein A-I-mediated signaling pathway|downregulation of apolipoprotein A-I-mediated signalling pathway|inhibition of apolipoprotein A-I-mediated signaling pathway|inhibition of apolipoprotein A-I-mediated signalling pathway|negative regulation of apolipoprotein A-I-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1905095 GO:1905096 biolink:BiologicalProcess positive regulation of apolipoprotein A-I-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. go.json activation of apolipoprotein A-I-mediated signaling pathway|activation of apolipoprotein A-I-mediated signalling pathway|positive regulation of apolipoprotein A-I-mediated signalling pathway|up regulation of apolipoprotein A-I-mediated signaling pathway|up regulation of apolipoprotein A-I-mediated signalling pathway|up-regulation of apolipoprotein A-I-mediated signaling pathway|up-regulation of apolipoprotein A-I-mediated signalling pathway|upregulation of apolipoprotein A-I-mediated signaling pathway|upregulation of apolipoprotein A-I-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1905096 GO:1905097 biolink:BiologicalProcess regulation of guanyl-nucleotide exchange factor activity Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity. go.json regulation of GDP-dissociation stimulator activity|regulation of GDS|regulation of GEF|regulation of GNRP|regulation of guanyl-nucleotide release factor activity|regulation of guanyl-nucleotide releasing factor http://purl.obolibrary.org/obo/GO_1905097 gocheck_do_not_annotate GO:1905098 biolink:BiologicalProcess negative regulation of guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity. go.json down regulation of GDP-dissociation stimulator activity|down regulation of GDS|down regulation of GEF|down regulation of GNRP|down regulation of guanyl-nucleotide exchange factor activity|down regulation of guanyl-nucleotide release factor activity|down regulation of guanyl-nucleotide releasing factor|down-regulation of GDP-dissociation stimulator activity|down-regulation of GDS|down-regulation of GEF|down-regulation of GNRP|down-regulation of guanyl-nucleotide exchange factor activity|down-regulation of guanyl-nucleotide release factor activity|down-regulation of guanyl-nucleotide releasing factor|downregulation of GDP-dissociation stimulator activity|downregulation of GDS|downregulation of GEF|downregulation of GNRP|downregulation of guanyl-nucleotide exchange factor activity|downregulation of guanyl-nucleotide release factor activity|downregulation of guanyl-nucleotide releasing factor|inhibition of GDP-dissociation stimulator activity|inhibition of GDS|inhibition of GEF|inhibition of GNRP|inhibition of guanyl-nucleotide exchange factor activity|inhibition of guanyl-nucleotide release factor activity|inhibition of guanyl-nucleotide releasing factor|negative regulation of GDP-dissociation stimulator activity|negative regulation of GDS|negative regulation of GEF|negative regulation of GNRP|negative regulation of guanyl-nucleotide release factor activity|negative regulation of guanyl-nucleotide releasing factor http://purl.obolibrary.org/obo/GO_1905098 gocheck_do_not_annotate GO:1905099 biolink:BiologicalProcess positive regulation of guanyl-nucleotide exchange factor activity Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity. go.json activation of GDP-dissociation stimulator activity|activation of GDS|activation of GEF|activation of GNRP|activation of guanyl-nucleotide exchange factor activity|activation of guanyl-nucleotide release factor activity|activation of guanyl-nucleotide releasing factor|positive regulation of GDP-dissociation stimulator activity|positive regulation of GDS|positive regulation of GEF|positive regulation of GNRP|positive regulation of guanyl-nucleotide release factor activity|positive regulation of guanyl-nucleotide releasing factor|up regulation of GDP-dissociation stimulator activity|up regulation of GDS|up regulation of GEF|up regulation of GNRP|up regulation of guanyl-nucleotide exchange factor activity|up regulation of guanyl-nucleotide release factor activity|up regulation of guanyl-nucleotide releasing factor|up-regulation of GDP-dissociation stimulator activity|up-regulation of GDS|up-regulation of GEF|up-regulation of GNRP|up-regulation of guanyl-nucleotide exchange factor activity|up-regulation of guanyl-nucleotide release factor activity|up-regulation of guanyl-nucleotide releasing factor|upregulation of GDP-dissociation stimulator activity|upregulation of GDS|upregulation of GEF|upregulation of GNRP|upregulation of guanyl-nucleotide exchange factor activity|upregulation of guanyl-nucleotide release factor activity|upregulation of guanyl-nucleotide releasing factor http://purl.obolibrary.org/obo/GO_1905099 gocheck_do_not_annotate GO:0016349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016349 GO:0016345 biolink:BiologicalProcess female meiotic chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis. go.json chromosome movement towards spindle pole during female meiosis|female meiotic chromosome movement|female meiotic chromosome movement to spindle pole http://purl.obolibrary.org/obo/GO_0016345 GO:0016346 biolink:BiologicalProcess male meiotic chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis. go.json chromosome movement towards spindle pole during male meiosis|male meiotic chromosome movement|male meiotic chromosome movement to spindle pole http://purl.obolibrary.org/obo/GO_0016346 GO:0016347 biolink:MolecularActivity obsolete calcium-independent cell adhesion molecule activity OBSOLETE. (Was not defined before being made obsolete). go.json calcium-independent cell adhesion molecule activity True http://purl.obolibrary.org/obo/GO_0016347 GO:0016348 biolink:BiologicalProcess imaginal disc-derived leg joint morphogenesis The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0016348 GO:0090286 biolink:BiologicalProcess obsolete cytoskeletal anchoring at nuclear membrane OBSOLETE. The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane. go.json True http://purl.obolibrary.org/obo/GO_0090286 GO:0031982 biolink:CellularComponent vesicle Any small, fluid-filled, spherical organelle enclosed by membrane. NIF_Subcellular:sao221389602|Wikipedia:Vesicle_(biology) go.json membrane-bounded vesicle|membrane-enclosed vesicle http://purl.obolibrary.org/obo/GO_0031982 goslim_pir GO:0016341 biolink:CellularComponent obsolete other collagen OBSOLETE. (Was not defined before being made obsolete). go.json other collagen True http://purl.obolibrary.org/obo/GO_0016341 GO:0090287 biolink:BiologicalProcess regulation of cellular response to growth factor stimulus Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. go.json http://purl.obolibrary.org/obo/GO_0090287 GO:0031983 biolink:CellularComponent vesicle lumen The volume enclosed by the membrane or protein that forms a vesicle. NIF_Subcellular:sao797538226 go.json http://purl.obolibrary.org/obo/GO_0031983 GO:0016342 biolink:CellularComponent catenin complex Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0016342 GO:0090284 biolink:BiologicalProcess obsolete positive regulation of protein glycosylation in Golgi OBSOLETE. Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus. go.json positive regulation of protein amino acid glycosylation in Golgi True http://purl.obolibrary.org/obo/GO_0090284 GO:0016343 biolink:MolecularActivity obsolete cytoskeletal anchoring activity OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane. go.json cytoskeletal anchoring activity True http://purl.obolibrary.org/obo/GO_0016343 GO:0031980 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031980 GO:0016344 biolink:BiologicalProcess meiotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis. go.json chromosome migration to spindle pole during meiosis|chromosome movement towards spindle pole during meiosis|meiotic chromosome movement|meiotic chromosome movement to spindle pole http://purl.obolibrary.org/obo/GO_0016344 GO:0031981 biolink:CellularComponent nuclear lumen The volume enclosed by the nuclear inner membrane. go.json http://purl.obolibrary.org/obo/GO_0031981 GO:0090285 biolink:BiologicalProcess obsolete negative regulation of protein glycosylation in Golgi OBSOLETE. Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus. go.json negative regulation of protein amino acid glycosylation in Golgi True http://purl.obolibrary.org/obo/GO_0090285 GO:0090288 biolink:BiologicalProcess negative regulation of cellular response to growth factor stimulus Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. go.json http://purl.obolibrary.org/obo/GO_0090288 GO:0090289 biolink:BiologicalProcess regulation of osteoclast proliferation Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. go.json http://purl.obolibrary.org/obo/GO_0090289 GO:0016340 biolink:BiologicalProcess calcium-dependent cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction. go.json http://purl.obolibrary.org/obo/GO_0016340 GO:0031979 biolink:CellularComponent plasma membrane-derived thylakoid lumen The volume enclosed by a plasma membrane-derived thylakoid. go.json plasma membrane thylakoid lumen http://purl.obolibrary.org/obo/GO_0031979 GO:0090290 biolink:BiologicalProcess positive regulation of osteoclast proliferation Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. go.json http://purl.obolibrary.org/obo/GO_0090290 GO:0031977 biolink:CellularComponent thylakoid lumen The volume enclosed by a thylakoid membrane. go.json http://purl.obolibrary.org/obo/GO_0031977 GO:0031978 biolink:CellularComponent plastid thylakoid lumen The volume enclosed by a plastid thylakoid membrane. go.json http://purl.obolibrary.org/obo/GO_0031978 GO:0090293 biolink:BiologicalProcess nitrogen catabolite regulation of transcription A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. go.json regulation of transcription by nitrogen catabolites http://purl.obolibrary.org/obo/GO_0090293 GO:0031975 biolink:CellularComponent envelope A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. go.json http://purl.obolibrary.org/obo/GO_0031975 GO:0090294 biolink:BiologicalProcess nitrogen catabolite activation of transcription A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. go.json positive regulation of transcription by nitrogen catabolites http://purl.obolibrary.org/obo/GO_0090294 GO:0031976 biolink:CellularComponent plastid thylakoid Any thylakoid within a plastid. go.json http://purl.obolibrary.org/obo/GO_0031976 GO:0090291 biolink:BiologicalProcess negative regulation of osteoclast proliferation Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. go.json http://purl.obolibrary.org/obo/GO_0090291 GO:0031973 biolink:CellularComponent chromoplast intermembrane space The region between the inner and outer lipid bilayers of a chromoplast envelope. go.json chromoplast envelope lumen http://purl.obolibrary.org/obo/GO_0031973 GO:0031974 biolink:CellularComponent membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. go.json http://purl.obolibrary.org/obo/GO_0031974 GO:0090292 biolink:BiologicalProcess nuclear matrix anchoring at nuclear membrane The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane. go.json nucleoskeleton anchoring at nuclear membrane http://purl.obolibrary.org/obo/GO_0090292 GO:0016356 biolink:BiologicalProcess obsolete organophosphorus susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json organophosphorus susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016356 GO:0016357 biolink:BiologicalProcess obsolete pyrethroid susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json pyrethroid susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016357 GO:0016358 biolink:BiologicalProcess dendrite development The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0016358 GO:0016359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016359 GO:0090297 biolink:BiologicalProcess positive regulation of mitochondrial DNA replication Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. go.json positive regulation of mitochondrial DNA synthesis http://purl.obolibrary.org/obo/GO_0090297 GO:0016352 biolink:BiologicalProcess obsolete insecticide susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json insecticide susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016352 GO:0031971 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031971 GO:0016353 biolink:BiologicalProcess obsolete carbamate susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json carbamate susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016353 GO:0031972 biolink:CellularComponent chloroplast intermembrane space The region between the inner and outer lipid bilayers of a chloroplast envelope. go.json chloroplast envelope lumen http://purl.obolibrary.org/obo/GO_0031972 GO:0090298 biolink:BiologicalProcess negative regulation of mitochondrial DNA replication Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. go.json negative regulation of mitochondrial DNA synthesis http://purl.obolibrary.org/obo/GO_0090298 GO:0090295 biolink:BiologicalProcess nitrogen catabolite repression of transcription A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. go.json negative regulation of transcription by nitrogen catabolites|nitrogen catabolite repression http://purl.obolibrary.org/obo/GO_0090295 GO:0016354 biolink:BiologicalProcess obsolete cyclodiene susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json cyclodiene susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016354 GO:0016355 biolink:BiologicalProcess obsolete DDT susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json DDT susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016355 GO:0090296 biolink:BiologicalProcess regulation of mitochondrial DNA replication Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. go.json regulation of mitochondrial DNA synthesis http://purl.obolibrary.org/obo/GO_0090296 GO:0031970 biolink:CellularComponent organelle envelope lumen The region between the inner and outer lipid bilayers of an organelle envelope. go.json organelle intermembrane space http://purl.obolibrary.org/obo/GO_0031970 GO:0090299 biolink:BiologicalProcess regulation of neural crest formation Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. go.json http://purl.obolibrary.org/obo/GO_0090299 GO:0016350 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016350 GO:0016351 biolink:BiologicalProcess obsolete drug susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json drug susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0016351 GO:0031968 biolink:CellularComponent organelle outer membrane The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. go.json http://purl.obolibrary.org/obo/GO_0031968 GO:0031969 biolink:CellularComponent chloroplast membrane Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. Wikipedia:Chloroplast_membrane go.json http://purl.obolibrary.org/obo/GO_0031969 GO:0031966 biolink:CellularComponent mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. NIF_Subcellular:sao1045389829 go.json http://purl.obolibrary.org/obo/GO_0031966 GO:0031967 biolink:CellularComponent organelle envelope A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. go.json http://purl.obolibrary.org/obo/GO_0031967 goslim_mouse GO:0090260 biolink:BiologicalProcess negative regulation of retinal ganglion cell axon guidance Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. go.json axon growth cone collapse http://purl.obolibrary.org/obo/GO_0090260 GO:0031964 biolink:MolecularActivity beta-alanyl-histamine hydrolase activity Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine. go.json carcinine hydrolase activity http://purl.obolibrary.org/obo/GO_0031964 GO:0090261 biolink:BiologicalProcess positive regulation of inclusion body assembly Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. go.json http://purl.obolibrary.org/obo/GO_0090261 GO:0031965 biolink:CellularComponent nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. NIF_Subcellular:sao1687101204 go.json http://purl.obolibrary.org/obo/GO_0031965 GO:0031962 biolink:MolecularActivity nuclear mineralocorticoid receptor binding Binding to a nuclear mineralocorticoid receptor. go.json mineralocorticoid receptor binding http://purl.obolibrary.org/obo/GO_0031962 GO:0031963 biolink:MolecularActivity nuclear cortisol receptor activity Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function. go.json cortisol receptor activity http://purl.obolibrary.org/obo/GO_0031963 GO:0016327 biolink:CellularComponent apicolateral plasma membrane The apical end of the lateral plasma membrane of epithelial cells. go.json apical lateral plasma membrane http://purl.obolibrary.org/obo/GO_0016327 GO:0016328 biolink:CellularComponent lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. go.json http://purl.obolibrary.org/obo/GO_0016328 GO:0016329 biolink:MolecularActivity obsolete apoptosis regulator activity OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis. go.json apoptosis regulator activity True http://purl.obolibrary.org/obo/GO_0016329 GO:0016323 biolink:CellularComponent basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. go.json http://purl.obolibrary.org/obo/GO_0016323 GO:0016324 biolink:CellularComponent apical plasma membrane The region of the plasma membrane located at the apical end of the cell. go.json http://purl.obolibrary.org/obo/GO_0016324 GO:0016325 biolink:BiologicalProcess oocyte microtubule cytoskeleton organization Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. go.json oocyte microtubule cytoskeleton organisation http://purl.obolibrary.org/obo/GO_0016325 GO:0016326 biolink:MolecularActivity obsolete kinesin motor activity OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules. go.json kinesin motor activity True http://purl.obolibrary.org/obo/GO_0016326 GO:0031960 biolink:BiologicalProcess response to corticosteroid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. go.json response to corticosteroid stimulus http://purl.obolibrary.org/obo/GO_0031960 GO:0090264 biolink:BiologicalProcess regulation of immune complex clearance by monocytes and macrophages Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. go.json http://purl.obolibrary.org/obo/GO_0090264 GO:0031961 biolink:MolecularActivity nuclear cortisol receptor binding Binding to a nuclear cortisol receptor. go.json cortisol receptor binding http://purl.obolibrary.org/obo/GO_0031961 GO:0090265 biolink:BiologicalProcess positive regulation of immune complex clearance by monocytes and macrophages Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. go.json http://purl.obolibrary.org/obo/GO_0090265 GO:0016320 biolink:BiologicalProcess endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum. go.json ER membrane fusion http://purl.obolibrary.org/obo/GO_0016320 GO:0090262 biolink:BiologicalProcess regulation of transcription-coupled nucleotide-excision repair Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. go.json http://purl.obolibrary.org/obo/GO_0090262 GO:0016321 biolink:BiologicalProcess female meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. go.json http://purl.obolibrary.org/obo/GO_0016321 GO:0090263 biolink:BiologicalProcess positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json positive regulation of Wnt receptor signaling pathway through beta-catenin|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signalling pathway|positive regulation of canonical Wnt-activated signaling pathway|positive regulation of catenin import into nucleus|positive regulation of catenin protein nuclear translocation http://purl.obolibrary.org/obo/GO_0090263 GO:0016322 biolink:BiologicalProcess neuron remodeling The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. go.json axon pruning|neuron remodelling|neuronal remodeling http://purl.obolibrary.org/obo/GO_0016322 GO:0090268 biolink:BiologicalProcess activation of mitotic cell cycle spindle assembly checkpoint Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint. go.json http://purl.obolibrary.org/obo/GO_0090268 GO:0090269 biolink:BiologicalProcess fibroblast growth factor production The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090269 gocheck_do_not_annotate GO:0090266 biolink:BiologicalProcess regulation of mitotic cell cycle spindle assembly checkpoint Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. go.json http://purl.obolibrary.org/obo/GO_0090266 GO:0090267 biolink:BiologicalProcess positive regulation of mitotic cell cycle spindle assembly checkpoint Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. go.json http://purl.obolibrary.org/obo/GO_0090267 GO:0031957 biolink:MolecularActivity very long-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22. Reactome:R-HSA-5695957|Reactome:R-HSA-5696007|Reactome:R-HSA-8875077 go.json very-long-chain fatty acid activation|very-long-chain fatty acid-CoA ligase activity|very-long-chain-fatty-acid-CoA ligase activity http://purl.obolibrary.org/obo/GO_0031957 GO:0031958 biolink:BiologicalProcess corticosteroid receptor signaling pathway The series of molecular signals initiated by corticosteroid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json corticosteroid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0031958 GO:0031955 biolink:MolecularActivity short-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons. go.json short-chain fatty acid activation|short-chain fatty-acid-CoA ligase activity|short-chain-fatty-acid-CoA ligase activity http://purl.obolibrary.org/obo/GO_0031955 GO:0031956 biolink:MolecularActivity medium-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. EC:6.2.1.2|RHEA:48340 go.json medium-chain fatty acid activation|medium-chain fatty-acid-CoA ligase activity|medium-chain-fatty-acid-CoA ligase activity http://purl.obolibrary.org/obo/GO_0031956 GO:0090271 biolink:BiologicalProcess positive regulation of fibroblast growth factor production Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090271 GO:0031953 biolink:BiologicalProcess negative regulation of protein autophosphorylation Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. go.json down regulation of protein amino acid autophosphorylation|down-regulation of protein amino acid autophosphorylation|downregulation of protein amino acid autophosphorylation|inhibition of protein amino acid autophosphorylation|negative regulation of protein amino acid autophosphorylation http://purl.obolibrary.org/obo/GO_0031953 GO:0031954 biolink:BiologicalProcess positive regulation of protein autophosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. go.json activation of protein amino acid autophosphorylation|positive regulation of protein amino acid autophosphorylation|stimulation of protein amino acid autophosphorylation|up regulation of protein amino acid autophosphorylation|up-regulation of protein amino acid autophosphorylation|upregulation of protein amino acid autophosphorylation http://purl.obolibrary.org/obo/GO_0031954 GO:0090272 biolink:BiologicalProcess negative regulation of fibroblast growth factor production Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090272 GO:0031951 biolink:BiologicalProcess positive regulation of glucocorticoid catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. go.json activation of glucocorticoid catabolic process|stimulation of glucocorticoid catabolic process|up regulation of glucocorticoid catabolic process|up-regulation of glucocorticoid catabolic process|upregulation of glucocorticoid catabolic process http://purl.obolibrary.org/obo/GO_0031951 GO:0031952 biolink:BiologicalProcess regulation of protein autophosphorylation Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. go.json regulation of protein amino acid autophosphorylation http://purl.obolibrary.org/obo/GO_0031952 GO:0090270 biolink:BiologicalProcess regulation of fibroblast growth factor production Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0090270 GO:0031959 biolink:BiologicalProcess mineralocorticoid receptor signaling pathway The series of molecular signals initiated by mineralocorticoid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json mineralocorticoid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0031959 GO:0016338 biolink:BiologicalProcess calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. go.json calcium-independent cell adhesion molecule activity http://purl.obolibrary.org/obo/GO_0016338 GO:0016339 biolink:BiologicalProcess calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. go.json calcium-dependent cell adhesion molecule activity http://purl.obolibrary.org/obo/GO_0016339 GO:0016334 biolink:BiologicalProcess establishment or maintenance of polarity of follicular epithelium Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0016334 GO:0016335 biolink:BiologicalProcess morphogenesis of larval imaginal disc epithelium The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0016335 GO:0016336 biolink:BiologicalProcess establishment or maintenance of polarity of larval imaginal disc epithelium Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium. go.json http://purl.obolibrary.org/obo/GO_0016336 GO:0016337 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016337 GO:0090275 biolink:BiologicalProcess negative regulation of somatostatin secretion Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. go.json http://purl.obolibrary.org/obo/GO_0090275 GO:0016330 biolink:BiologicalProcess second mitotic wave involved in compound eye morphogenesis A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia. go.json second mitotic wave during compound eye morphogenesis http://purl.obolibrary.org/obo/GO_0016330 GO:0090276 biolink:BiologicalProcess regulation of peptide hormone secretion Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. go.json http://purl.obolibrary.org/obo/GO_0090276 GO:0016331 biolink:BiologicalProcess morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0016331 GO:0031950 biolink:BiologicalProcess negative regulation of glucocorticoid catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. go.json down regulation of glucocorticoid catabolic process|down-regulation of glucocorticoid catabolic process|downregulation of glucocorticoid catabolic process|inhibition of glucocorticoid catabolic process http://purl.obolibrary.org/obo/GO_0031950 GO:0090273 biolink:BiologicalProcess regulation of somatostatin secretion Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. go.json http://purl.obolibrary.org/obo/GO_0090273 GO:0016332 biolink:BiologicalProcess establishment or maintenance of polarity of embryonic epithelium Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo. go.json http://purl.obolibrary.org/obo/GO_0016332 GO:0016333 biolink:BiologicalProcess morphogenesis of follicular epithelium The process in which the anatomical structures of a follicular epithelium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0016333 GO:0090274 biolink:BiologicalProcess positive regulation of somatostatin secretion Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. go.json http://purl.obolibrary.org/obo/GO_0090274 GO:0090279 biolink:BiologicalProcess regulation of calcium ion import Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. go.json regulation of transmembrane calcium influx http://purl.obolibrary.org/obo/GO_0090279 GO:0090277 biolink:BiologicalProcess positive regulation of peptide hormone secretion Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. go.json http://purl.obolibrary.org/obo/GO_0090277 GO:0090278 biolink:BiologicalProcess negative regulation of peptide hormone secretion Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. go.json http://purl.obolibrary.org/obo/GO_0090278 GO:0031946 biolink:BiologicalProcess regulation of glucocorticoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. go.json http://purl.obolibrary.org/obo/GO_0031946 GO:0031947 biolink:BiologicalProcess negative regulation of glucocorticoid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. go.json down regulation of glucocorticoid biosynthetic process|down-regulation of glucocorticoid biosynthetic process|downregulation of glucocorticoid biosynthetic process|inhibition of glucocorticoid biosynthetic process http://purl.obolibrary.org/obo/GO_0031947 GO:0031944 biolink:BiologicalProcess negative regulation of glucocorticoid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. go.json down regulation of glucocorticoid metabolic process|down-regulation of glucocorticoid metabolic process|downregulation of glucocorticoid metabolic process|inhibition of glucocorticoid metabolic process|negative regulation of glucocorticoid metabolism http://purl.obolibrary.org/obo/GO_0031944 GO:0006988 biolink:BiologicalProcess obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor OBSOLETE. (Was not defined before being made obsolete). go.json unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor True http://purl.obolibrary.org/obo/GO_0006988 GO:0006989 biolink:BiologicalProcess obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase OBSOLETE. (Was not defined before being made obsolete). go.json unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase True http://purl.obolibrary.org/obo/GO_0006989 GO:0031945 biolink:BiologicalProcess positive regulation of glucocorticoid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. go.json activation of glucocorticoid metabolic process|positive regulation of glucocorticoid metabolism|stimulation of glucocorticoid metabolic process|up regulation of glucocorticoid metabolic process|up-regulation of glucocorticoid metabolic process|upregulation of glucocorticoid metabolic process http://purl.obolibrary.org/obo/GO_0031945 GO:0006986 biolink:BiologicalProcess response to unfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. go.json heat shock protein activity http://purl.obolibrary.org/obo/GO_0006986 GO:0031942 biolink:CellularComponent i-AAA complex Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. go.json http://purl.obolibrary.org/obo/GO_0031942 GO:0006987 biolink:BiologicalProcess obsolete activation of signaling protein activity involved in unfolded protein response OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response. go.json unfolded protein response, activation of signaling protein activity|unfolded protein response, activation of signaling protein kinase/endonuclease|unfolded protein response, activation of signalling protein kinase/endonuclease True http://purl.obolibrary.org/obo/GO_0006987 GO:0031943 biolink:BiologicalProcess regulation of glucocorticoid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. go.json regulation of glucocorticoid metabolism http://purl.obolibrary.org/obo/GO_0031943 GO:0031940 biolink:BiologicalProcess obsolete positive regulation of chromatin silencing at telomere OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres. go.json activation of chromatin silencing at telomere|positive regulation of heterochromatic silencing at telomere|stimulation of chromatin silencing at telomere|up regulation of chromatin silencing at telomere|up-regulation of chromatin silencing at telomere|upregulation of chromatin silencing at telomere True http://purl.obolibrary.org/obo/GO_0031940 GO:0006984 biolink:BiologicalProcess ER-nucleus signaling pathway The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. go.json ER to nucleus signaling pathway|ER to nucleus signalling pathway|ER-nuclear signaling pathway|ER-nuclear signalling pathway|endoplasmic reticulum to nucleus signaling pathway|endoplasmic reticulum-nuclear signaling pathway http://purl.obolibrary.org/obo/GO_0006984 GO:0006985 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006985 GO:0031941 biolink:CellularComponent filamentous actin A two-stranded helical polymer of the protein actin. Wikipedia:Actin go.json F-actin http://purl.obolibrary.org/obo/GO_0031941 GO:0006982 biolink:BiologicalProcess response to lipid hydroperoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids. go.json response to LHPO http://purl.obolibrary.org/obo/GO_0006982 GO:0006983 biolink:BiologicalProcess ER overload response The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB. go.json EOR|EOR-mediated NF-kappaB activation|EOR-mediated activation of NF-kappaB|ER-overload response|endoplasmic reticulum overload response|positive regulation of NF-kappaB transcription factor activity by EOR|positive regulation of NF-kappaB transcription factor activity by ER overload response http://purl.obolibrary.org/obo/GO_0006983 GO:0006980 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006980 GO:0006981 biolink:BiologicalProcess obsolete activation of SoxR protein OBSOLETE. The conversion of the SoxR transcription factor to its active (oxidized) form. go.json True http://purl.obolibrary.org/obo/GO_0006981 GO:0016309 biolink:MolecularActivity 1-phosphatidylinositol-5-phosphate 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. EC:2.7.1.149|MetaCyc:2.7.1.149-RXN|RHEA:12280|Reactome:R-HSA-1675776|Reactome:R-HSA-6811522 go.json 1-phosphatidylinositol-5-phosphate kinase|ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity|PIP4K|type II PIP kinase activity http://purl.obolibrary.org/obo/GO_0016309 GO:0031948 biolink:BiologicalProcess positive regulation of glucocorticoid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. go.json activation of glucocorticoid biosynthetic process|stimulation of glucocorticoid biosynthetic process|up regulation of glucocorticoid biosynthetic process|up-regulation of glucocorticoid biosynthetic process|upregulation of glucocorticoid biosynthetic process http://purl.obolibrary.org/obo/GO_0031948 GO:0031949 biolink:BiologicalProcess regulation of glucocorticoid catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. go.json http://purl.obolibrary.org/obo/GO_0031949 GO:0016305 biolink:MolecularActivity obsolete phosphatidylinositol 3-kinase activity, class II OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine. go.json PI3KC2|phosphatidylinositol 3-kinase activity, class II True http://purl.obolibrary.org/obo/GO_0016305 GO:0016306 biolink:MolecularActivity obsolete phosphatidylinositol 3-kinase activity, class III OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol. go.json phosphatidylinositol 3-kinase activity, class III True http://purl.obolibrary.org/obo/GO_0016306 GO:0016307 biolink:MolecularActivity obsolete phosphatidylinositol phosphate kinase activity OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. go.json phosphatidylinositol monophosphate kinase activity True http://purl.obolibrary.org/obo/GO_0016307 GO:0016308 biolink:MolecularActivity 1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+. EC:2.7.1.68|KEGG_REACTION:R03469|MetaCyc:2.7.1.68-RXN|RHEA:14425|Reactome:R-HSA-1676082|Reactome:R-HSA-3772436|Reactome:R-HSA-8868066 go.json 1-phosphatidylinositol-4-phosphate kinase activity|1-phosphatidylinositol-4-phosphate kinase, class IA|1-phosphatidylinositol-4-phosphate kinase, class IB|ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity|PI(4)5K|PIP kinase activity|PIP5K|PtdIns(4)P-5-kinase activity|diphosphoinositide kinase activity|phosphatidylinositol 4-phosphate kinase activity|phosphatidylinositol-4-phosphate 5-kinase activity|type I PIP kinase activity http://purl.obolibrary.org/obo/GO_0016308 GO:0016301 biolink:MolecularActivity kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. Reactome:R-HSA-6788855|Reactome:R-HSA-6788867 go.json phosphokinase activity http://purl.obolibrary.org/obo/GO_0016301 goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_plant|goslim_yeast GO:0016302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016302 GO:0016303 biolink:MolecularActivity 1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+. EC:2.7.1.137|KEGG_REACTION:R03362|MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN|RHEA:12709|Reactome:R-HSA-109699|Reactome:R-HSA-1433514|Reactome:R-HSA-1675939|Reactome:R-HSA-1675961|Reactome:R-HSA-1676024|Reactome:R-HSA-2045911|Reactome:R-HSA-5672012|Reactome:R-HSA-6798174|Reactome:R-HSA-9028519|Reactome:R-HSA-9670433|Reactome:R-HSA-9680389|Wikipedia:Phosphoinositide_3-kinase go.json 1-phosphatidylinositol 3-kinase activity|PI3-kinase activity|PI3K|PtdIns-3-kinase activity|phosphatidylinositol 3-kinase activity, class I|phosphatidylinositol 3-kinase activity, class II|phosphatidylinositol 3-kinase activity, class III|phosphatidylinositol 3-kinase, class I, catalyst activity|type I phosphatidylinositol kinase activity|type III phosphoinositide 3-kinase activity http://purl.obolibrary.org/obo/GO_0016303 GO:0016304 biolink:MolecularActivity obsolete phosphatidylinositol 3-kinase activity, class I OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity. go.json phosphatidylinositol 3-kinase activity, class I True http://purl.obolibrary.org/obo/GO_0016304 GO:0016300 biolink:MolecularActivity tRNA (uridine) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. go.json tRNA (uracil) methyltransferase activity http://purl.obolibrary.org/obo/GO_0016300 GO:0031935 biolink:BiologicalProcess obsolete regulation of chromatin silencing OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing. go.json regulation of heterochromatic silencing True http://purl.obolibrary.org/obo/GO_0031935 GO:0031936 biolink:BiologicalProcess obsolete negative regulation of chromatin silencing OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing. go.json down regulation of chromatin silencing|down-regulation of chromatin silencing|downregulation of chromatin silencing|inhibition of chromatin silencing|loss of chromatin silencing|negative regulation of heterochromatic silencing True http://purl.obolibrary.org/obo/GO_0031936 GO:0031933 biolink:CellularComponent obsolete telomeric heterochromatin OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres. go.json telomeric chromatin True http://purl.obolibrary.org/obo/GO_0031933 GO:0006999 biolink:BiologicalProcess nuclear pore organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. go.json nuclear pore complex organization and biogenesis|nuclear pore organisation|nuclear pore organization and biogenesis http://purl.obolibrary.org/obo/GO_0006999 GO:0031934 biolink:CellularComponent mating-type region heterochromatin Heterochromatic regions of the chromosome found at silenced mating-type loci. go.json http://purl.obolibrary.org/obo/GO_0031934 GO:0031931 biolink:CellularComponent TORC1 complex A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. Wikipedia:MTORC1 go.json TOR complex 1|TORC 1 complex|TORC1|dTOR/dRaptor complex|dTORC1|mTORC1|nutrient sensitive complex|rapamycin and nutrient-sensitive TOR complex http://purl.obolibrary.org/obo/GO_0031931 GO:0006997 biolink:BiologicalProcess nucleus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. go.json nuclear morphology|nuclear organisation|nuclear organization|nuclear organization and biogenesis|nucleus organization and biogenesis http://purl.obolibrary.org/obo/GO_0006997 goslim_candida|goslim_drosophila|goslim_pir|goslim_yeast GO:0031932 biolink:CellularComponent TORC2 complex A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. Wikipedia:MTORC1 go.json TOR complex 2|TORC 2 complex|TORC2|mTORC2|rapamycin and nutrient-insensitive TOR complex http://purl.obolibrary.org/obo/GO_0031932 GO:0006998 biolink:BiologicalProcess nuclear envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. go.json nuclear envelope organisation|nuclear envelope organization and biogenesis http://purl.obolibrary.org/obo/GO_0006998 GO:0006995 biolink:BiologicalProcess cellular response to nitrogen starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. go.json http://purl.obolibrary.org/obo/GO_0006995 GO:0031930 biolink:BiologicalProcess mitochondria-nucleus signaling pathway The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function. go.json mitochondria-nucleus signal transduction|mitochondrial signaling pathway|mitochondrial signalling pathway|retrograde response http://purl.obolibrary.org/obo/GO_0031930 GO:0006996 biolink:BiologicalProcess organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. go.json organelle organisation|organelle organization and biogenesis|single organism organelle organization|single-organism organelle organization http://purl.obolibrary.org/obo/GO_0006996 goslim_candida|goslim_pir GO:0006993 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006993 GO:0006994 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006994 GO:0006991 biolink:BiologicalProcess response to sterol depletion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json sterol depletion response http://purl.obolibrary.org/obo/GO_0006991 GO:0006992 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006992 GO:0031939 biolink:BiologicalProcess obsolete negative regulation of chromatin silencing at telomere OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres. go.json down regulation of chromatin silencing at telomere|down-regulation of chromatin silencing at telomere|downregulation of chromatin silencing at telomere|inhibition of chromatin silencing at telomere|negative regulation of heterochromatic silencing at telomere True http://purl.obolibrary.org/obo/GO_0031939 GO:0006990 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response. go.json positive regulation of transcription of target genes involved in unfolded protein response|unfolded protein response, activation of target gene transcription|unfolded protein response, positive regulation of target gene transcription|unfolded protein response, stimulation of target gene transcription|unfolded protein response, target gene transcriptional activation|unfolded protein response, up regulation of target gene transcription|unfolded protein response, up-regulation of target gene transcription|unfolded protein response, upregulation of target gene transcription True http://purl.obolibrary.org/obo/GO_0006990 GO:0031937 biolink:BiologicalProcess obsolete positive regulation of chromatin silencing OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing. go.json activation of chromatin silencing|positive regulation of heterochromatic silencing|stimulation of chromatin silencing|up regulation of chromatin silencing|up-regulation of chromatin silencing|upregulation of chromatin silencing True http://purl.obolibrary.org/obo/GO_0031937 GO:0031938 biolink:BiologicalProcess obsolete regulation of chromatin silencing at telomere OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing at telomeres. go.json regulation of heterochromatic silencing at telomere True http://purl.obolibrary.org/obo/GO_0031938 GO:0016316 biolink:MolecularActivity phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. EC:3.1.3.66|MetaCyc:3.1.3.66-RXN|RHEA:17193|Reactome:R-HSA-1676162|Reactome:R-HSA-1676164 go.json 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity|inositol polyphosphate 4-phosphatase type II activity http://purl.obolibrary.org/obo/GO_0016316 GO:0016318 biolink:BiologicalProcess ommatidial rotation The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification. go.json http://purl.obolibrary.org/obo/GO_0016318 GO:0016319 biolink:BiologicalProcess mushroom body development The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells. go.json http://purl.obolibrary.org/obo/GO_0016319 GO:0016312 biolink:MolecularActivity inositol bisphosphate phosphatase activity Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. RHEA:57840|Reactome:R-HSA-6809561|Reactome:R-HSA-6809565 go.json http://purl.obolibrary.org/obo/GO_0016312 GO:0016313 biolink:MolecularActivity obsolete inositol-1,4,5-trisphosphate phosphatase OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate. go.json inositol-1,4,5-trisphosphate phosphatase True http://purl.obolibrary.org/obo/GO_0016313 GO:0016314 biolink:MolecularActivity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. EC:3.1.3.67|MetaCyc:3.1.3.67-RXN|RHEA:25017|Reactome:R-HSA-199456|Reactome:R-HSA-202237|Reactome:R-HSA-2317387 go.json 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity|MMAC1|PI(3)P 3-phosphatase activity|PI(3,4,5)P3 3-phosphatase activity|PtdIns(3,4,5)P3 3-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0016314 GO:0016315 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016315 GO:0016310 biolink:BiologicalProcess phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. Wikipedia:Phosphorylation go.json http://purl.obolibrary.org/obo/GO_0016310 goslim_chembl|goslim_metagenomics GO:0016311 biolink:BiologicalProcess dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. Wikipedia:Dephosphorylation go.json http://purl.obolibrary.org/obo/GO_0016311 GO:0031924 biolink:MolecularActivity vitamin B6 transmembrane transporter activity Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other. go.json vitamin B6 transporter activity http://purl.obolibrary.org/obo/GO_0031924 GO:0006968 biolink:BiologicalProcess cellular defense response A defense response that is mediated by cells. go.json cellular defence response|intracellular defence response|intracellular defense response http://purl.obolibrary.org/obo/GO_0006968 GO:0006969 biolink:BiologicalProcess obsolete melanotic tumor response OBSOLETE. (Was not defined before being made obsolete). go.json melanotic mass response|melanotic tumor response True http://purl.obolibrary.org/obo/GO_0006969 GO:0031925 biolink:MolecularActivity pyridoxal transmembrane transporter activity Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json pyridoxal transporter activity http://purl.obolibrary.org/obo/GO_0031925 GO:0031922 biolink:BiologicalProcess pyridoxamine transport The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0031922 GO:0006966 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006966 GO:0006967 biolink:BiologicalProcess positive regulation of antifungal peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis. go.json activation of antifungal peptide biosynthetic process|antifungal peptide induction|antifungal polypeptide induction|stimulation of antifungal peptide biosynthetic process|up regulation of antifungal peptide biosynthetic process|up-regulation of antifungal peptide biosynthetic process|upregulation of antifungal peptide biosynthetic process http://purl.obolibrary.org/obo/GO_0006967 GO:0031923 biolink:BiologicalProcess pyridoxine transport The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0031923 GO:0006964 biolink:BiologicalProcess positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria. go.json activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|anti-Gram-negative bacterial peptide induction|anti-Gram-negative bacterial polypeptide induction|stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria|upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria http://purl.obolibrary.org/obo/GO_0006964 GO:0031920 biolink:BiologicalProcess pyridoxal transport The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0031920 GO:0006965 biolink:BiologicalProcess positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria. go.json activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|anti-Gram-positive bacterial peptide induction|anti-Gram-positive bacterial polypeptide induction|stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria http://purl.obolibrary.org/obo/GO_0006965 GO:0031921 biolink:BiologicalProcess pyridoxal phosphate transport The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0031921 GO:0006962 biolink:BiologicalProcess male-specific antibacterial humoral response An immune response against bacteria, specific to males and mediated through a body fluid. go.json http://purl.obolibrary.org/obo/GO_0006962 GO:0006963 biolink:BiologicalProcess positive regulation of antibacterial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis. go.json activation of antibacterial peptide biosynthetic process|antibacterial peptide induction|antibacterial polypeptide induction|stimulation of antibacterial peptide biosynthetic process|up regulation of antibacterial peptide biosynthetic process|up-regulation of antibacterial peptide biosynthetic process|upregulation of antibacterial peptide biosynthetic process http://purl.obolibrary.org/obo/GO_0006963 GO:0006960 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006960 GO:0006961 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006961 GO:0031928 biolink:MolecularActivity pyridoxine transmembrane transporter activity Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json pyridoxine transporter activity http://purl.obolibrary.org/obo/GO_0031928 GO:0031929 biolink:BiologicalProcess TOR signaling The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. go.json TOR signal transduction|TOR signaling cascade|TOR signaling pathway|TOR signalling pathway|target of rapamycin signaling pathway|target of rapamycin signalling pathway http://purl.obolibrary.org/obo/GO_0031929 GO:0031926 biolink:MolecularActivity pyridoxal phosphate transmembrane transporter activity Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0031926 GO:0031927 biolink:MolecularActivity pyridoxamine transmembrane transporter activity Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0031927 GO:0031913 biolink:CellularComponent contractile vacuole pore Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium. go.json http://purl.obolibrary.org/obo/GO_0031913 GO:0006979 biolink:BiologicalProcess response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0006979 goslim_yeast GO:0031914 biolink:BiologicalProcess negative regulation of synaptic plasticity A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. go.json down regulation of synaptic plasticity|down-regulation of synaptic plasticity|downregulation of synaptic plasticity|inhibition of synaptic plasticity http://purl.obolibrary.org/obo/GO_0031914 GO:0006977 biolink:BiologicalProcess DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle. go.json positive regulation of cell cycle arrest by p53-mediated DNA damage response http://purl.obolibrary.org/obo/GO_0006977 GO:0031911 biolink:CellularComponent cytoproct Stable, specialized structure for extrusion of waste by the cell into the surrounding medium. go.json http://purl.obolibrary.org/obo/GO_0031911 GO:0031912 biolink:CellularComponent oral apparatus Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems. go.json http://purl.obolibrary.org/obo/GO_0031912 GO:0006978 biolink:BiologicalProcess DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. go.json http://purl.obolibrary.org/obo/GO_0006978 GO:0006975 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006975 GO:0031910 biolink:CellularComponent cytostome Stable, specialized structure for the ingestion of food by the cell into phagosomes. Wikipedia:Cytostome go.json http://purl.obolibrary.org/obo/GO_0031910 GO:0006976 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006976 GO:0006973 biolink:BiologicalProcess intracellular accumulation of glycerol The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment. go.json http://purl.obolibrary.org/obo/GO_0006973 GO:0006974 biolink:BiologicalProcess DNA damage response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. go.json cellular DNA damage response|cellular response to DNA damage stimulus|response to DNA damage stimulus|response to genotoxic stress http://purl.obolibrary.org/obo/GO_0006974 goslim_yeast GO:0006971 biolink:BiologicalProcess hypotonic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. go.json hypo-osmotic response http://purl.obolibrary.org/obo/GO_0006971 GO:0006972 biolink:BiologicalProcess hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. go.json HOG response|hypertonic response|response to hypertonicity http://purl.obolibrary.org/obo/GO_0006972 GO:0031919 biolink:BiologicalProcess vitamin B6 transport The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0031919 GO:0006970 biolink:BiologicalProcess response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json osmotic response|osmotic stress response http://purl.obolibrary.org/obo/GO_0006970 goslim_yeast GO:0031917 biolink:BiologicalProcess negative regulation of synaptic metaplasticity A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. go.json down regulation of synaptic metaplasticity|down-regulation of synaptic metaplasticity|downregulation of synaptic metaplasticity|inhibition of synaptic metaplasticity http://purl.obolibrary.org/obo/GO_0031917 GO:0031918 biolink:BiologicalProcess positive regulation of synaptic metaplasticity A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. go.json activation of synaptic metaplasticity|stimulation of synaptic metaplasticity|up regulation of synaptic metaplasticity|up-regulation of synaptic metaplasticity|upregulation of synaptic metaplasticity http://purl.obolibrary.org/obo/GO_0031918 GO:0031915 biolink:BiologicalProcess positive regulation of synaptic plasticity A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. go.json activation of synaptic plasticity|stimulation of synaptic plasticity|up regulation of synaptic plasticity|up-regulation of synaptic plasticity|upregulation of synaptic plasticity http://purl.obolibrary.org/obo/GO_0031915 GO:0031916 biolink:BiologicalProcess regulation of synaptic metaplasticity A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. go.json http://purl.obolibrary.org/obo/GO_0031916 GO:1905010 biolink:BiologicalProcess positive regulation of L-lysine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-lysine import into cell. go.json activation of L-lysine import into cell|positive regulation of L-lysine import into cell|up regulation of L-lysine import into cell|up-regulation of L-lysine import into cell|upregulation of L-lysine import into cell http://purl.obolibrary.org/obo/GO_1905010 GO:1905011 biolink:BiologicalProcess transmembrane phosphate ion transport from cytosol to vacuole The directed movement of phosphate ions from the cytosol across the vacuolar membrane and into the vacuolar lumen. go.json vacuolar phosphate transport http://purl.obolibrary.org/obo/GO_1905011 GO:1905012 biolink:BiologicalProcess regulation of 'de novo' NAD biosynthetic process from tryptophan Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. go.json regulation of de novo NAD biosynthetic process from tryptophan http://purl.obolibrary.org/obo/GO_1905012 GO:1905013 biolink:BiologicalProcess negative regulation of 'de novo' NAD biosynthetic process from tryptophan Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. go.json down regulation of 'de novo' NAD biosynthetic process from tryptophan|down regulation of de novo NAD biosynthetic process from tryptophan|down-regulation of 'de novo' NAD biosynthetic process from tryptophan|down-regulation of de novo NAD biosynthetic process from tryptophan|downregulation of 'de novo' NAD biosynthetic process from tryptophan|downregulation of de novo NAD biosynthetic process from tryptophan|inhibition of 'de novo' NAD biosynthetic process from tryptophan|inhibition of de novo NAD biosynthetic process from tryptophan|negative regulation of de novo NAD biosynthetic process from tryptophan http://purl.obolibrary.org/obo/GO_1905013 GO:1905014 biolink:BiologicalProcess positive regulation of 'de novo' NAD biosynthetic process from tryptophan Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. go.json activation of 'de novo' NAD biosynthetic process from tryptophan|activation of de novo NAD biosynthetic process from tryptophan|positive regulation of de novo NAD biosynthetic process from tryptophan|up regulation of 'de novo' NAD biosynthetic process from tryptophan|up regulation of de novo NAD biosynthetic process from tryptophan|up-regulation of 'de novo' NAD biosynthetic process from tryptophan|up-regulation of de novo NAD biosynthetic process from tryptophan|upregulation of 'de novo' NAD biosynthetic process from tryptophan|upregulation of de novo NAD biosynthetic process from tryptophan http://purl.obolibrary.org/obo/GO_1905014 GO:1905004 biolink:BiologicalProcess picolinic acid biosynthetic process The chemical reactions and pathways resulting in the formation of picolinic acid. go.json picolinate biosynthesis|picolinate biosynthetic process|picolinic acid anabolism|picolinic acid biosynthesis|picolinic acid formation|picolinic acid synthesis http://purl.obolibrary.org/obo/GO_1905004 GO:0090448 biolink:MolecularActivity glucosinolate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in). go.json glucosinolate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0090448 GO:0090449 biolink:BiologicalProcess phloem glucosinolate loading The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink. go.json http://purl.obolibrary.org/obo/GO_0090449 GO:1905005 biolink:BiologicalProcess regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. go.json http://purl.obolibrary.org/obo/GO_1905005 GO:1905006 biolink:BiologicalProcess negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. go.json down regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|down-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|downregulation of epithelial to mesenchymal transition involved in endocardial cushion formation|inhibition of epithelial to mesenchymal transition involved in endocardial cushion formation http://purl.obolibrary.org/obo/GO_1905006 GO:0090446 biolink:BiologicalProcess negative regulation of nematode larval development, heterochronic Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached. go.json http://purl.obolibrary.org/obo/GO_0090446 GO:1905007 biolink:BiologicalProcess positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. go.json activation of epithelial to mesenchymal transition involved in endocardial cushion formation|up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|up-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|upregulation of epithelial to mesenchymal transition involved in endocardial cushion formation http://purl.obolibrary.org/obo/GO_1905007 GO:0090447 biolink:MolecularActivity glycerol-3-phosphate 2-O-acyltransferase activity Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate. EC:2.3.1.198|RHEA:33559 go.json http://purl.obolibrary.org/obo/GO_0090447 GO:1905008 biolink:BiologicalProcess regulation of L-lysine import across plasma membrane Any process that modulates the frequency, rate or extent of L-lysine import into cell. go.json regulation of L-lysine import into cell|regulation of lysine import|regulation of lysine uptake http://purl.obolibrary.org/obo/GO_1905008 GO:1905009 biolink:BiologicalProcess negative regulation of L-lysine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-lysine import into cell. go.json down regulation of L-lysine import into cell|down-regulation of L-lysine import into cell|downregulation of L-lysine import into cell|inhibition of L-lysine import into cell|negative regulation of L-lysine import into cell|negative regulation of lysine import|negative regulation of lysine uptake http://purl.obolibrary.org/obo/GO_1905009 GO:0090440 biolink:MolecularActivity abscisic acid transmembrane transporter activity Enables the transfer of abscisic acid from one side of a membrane to the other. go.json abscisic acid transporter activity http://purl.obolibrary.org/obo/GO_0090440 GO:0090441 biolink:BiologicalProcess trehalose biosynthesis in response to heat stress The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. go.json trehalose biosynthetic process in response to heat stress http://purl.obolibrary.org/obo/GO_0090441 GO:0090444 biolink:BiologicalProcess regulation of nematode larval development, heterochronic Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached. go.json http://purl.obolibrary.org/obo/GO_0090444 GO:0090445 biolink:BiologicalProcess positive regulation of nematode larval development, heterochronic Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached. go.json http://purl.obolibrary.org/obo/GO_0090445 GO:0090442 biolink:BiologicalProcess trehalose catabolism in response to heat stress The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. go.json trehalose catabolic process in response to heat stress http://purl.obolibrary.org/obo/GO_0090442 GO:0090443 biolink:CellularComponent FAR/SIN/STRIPAK complex A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body. go.json FAR complex|SIN inhibitory phosphatase (SIP) complex|SIN inhibitory phosphatase complex|SIP complex|STRIPAK signalling complex|striatin interacting phosphatase and kinase complex http://purl.obolibrary.org/obo/GO_0090443 GO:1905020 biolink:BiologicalProcess positive regulation of methionine-tRNA ligase activity Any process that activates or increases the frequency, rate or extent of methionine-tRNA ligase activity. go.json activation of L-methionine:tRNAMet ligase (AMP-forming)|activation of MetRS activity|activation of methionine translase activity|activation of methionine-tRNA ligase activity|activation of methionyl-tRNA synthetase activity|activation of methionyl-transfer RNA synthetase activity|activation of methionyl-transfer ribonucleate synthetase activity|activation of methionyl-transfer ribonucleic acid synthetase activity|positive regulation of L-methionine:tRNAMet ligase (AMP-forming)|positive regulation of MetRS activity|positive regulation of methionine translase activity|positive regulation of methionyl-tRNA synthetase activity|positive regulation of methionyl-transfer RNA synthetase activity|positive regulation of methionyl-transfer ribonucleate synthetase activity|positive regulation of methionyl-transfer ribonucleic acid synthetase activity|up regulation of L-methionine:tRNAMet ligase (AMP-forming)|up regulation of MetRS activity|up regulation of methionine translase activity|up regulation of methionine-tRNA ligase activity|up regulation of methionyl-tRNA synthetase activity|up regulation of methionyl-transfer RNA synthetase activity|up regulation of methionyl-transfer ribonucleate synthetase activity|up regulation of methionyl-transfer ribonucleic acid synthetase activity|up-regulation of L-methionine:tRNAMet ligase (AMP-forming)|up-regulation of MetRS activity|up-regulation of methionine translase activity|up-regulation of methionine-tRNA ligase activity|up-regulation of methionyl-tRNA synthetase activity|up-regulation of methionyl-transfer RNA synthetase activity|up-regulation of methionyl-transfer ribonucleate synthetase activity|up-regulation of methionyl-transfer ribonucleic acid synthetase activity|upregulation of L-methionine:tRNAMet ligase (AMP-forming)|upregulation of MetRS activity|upregulation of methionine translase activity|upregulation of methionine-tRNA ligase activity|upregulation of methionyl-tRNA synthetase activity|upregulation of methionyl-transfer RNA synthetase activity|upregulation of methionyl-transfer ribonucleate synthetase activity|upregulation of methionyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_1905020 gocheck_do_not_annotate GO:1905021 biolink:BiologicalProcess obsolete regulation of threonine-tRNA ligase activity OBSOLETE. Any process that modulates the frequency, rate or extent of threonine-tRNA ligase activity. go.json regulation of L-threonine:tRNAThr ligase (AMP-forming)|regulation of TRS|regulation of threonine translase activity|regulation of threonine-transfer ribonucleate synthetase activity|regulation of threonyl ribonucleic synthetase activity|regulation of threonyl-tRNA synthetase activity|regulation of threonyl-transfer RNA synthetase activity|regulation of threonyl-transfer ribonucleate synthetase activity|regulation of threonyl-transfer ribonucleic acid synthetase activity True http://purl.obolibrary.org/obo/GO_1905021 GO:1905022 biolink:BiologicalProcess obsolete negative regulation of threonine-tRNA ligase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of threonine-tRNA ligase activity. go.json down regulation of L-threonine:tRNAThr ligase (AMP-forming)|down regulation of TRS|down regulation of threonine translase activity|down regulation of threonine-tRNA ligase activity|down regulation of threonine-transfer ribonucleate synthetase activity|down regulation of threonyl ribonucleic synthetase activity|down regulation of threonyl-tRNA synthetase activity|down regulation of threonyl-transfer RNA synthetase activity|down regulation of threonyl-transfer ribonucleate synthetase activity|down regulation of threonyl-transfer ribonucleic acid synthetase activity|down-regulation of L-threonine:tRNAThr ligase (AMP-forming)|down-regulation of TRS|down-regulation of threonine translase activity|down-regulation of threonine-tRNA ligase activity|down-regulation of threonine-transfer ribonucleate synthetase activity|down-regulation of threonyl ribonucleic synthetase activity|down-regulation of threonyl-tRNA synthetase activity|down-regulation of threonyl-transfer RNA synthetase activity|down-regulation of threonyl-transfer ribonucleate synthetase activity|down-regulation of threonyl-transfer ribonucleic acid synthetase activity|downregulation of L-threonine:tRNAThr ligase (AMP-forming)|downregulation of TRS|downregulation of threonine translase activity|downregulation of threonine-tRNA ligase activity|downregulation of threonine-transfer ribonucleate synthetase activity|downregulation of threonyl ribonucleic synthetase activity|downregulation of threonyl-tRNA synthetase activity|downregulation of threonyl-transfer RNA synthetase activity|downregulation of threonyl-transfer ribonucleate synthetase activity|downregulation of threonyl-transfer ribonucleic acid synthetase activity|inhibition of L-threonine:tRNAThr ligase (AMP-forming)|inhibition of TRS|inhibition of threonine translase activity|inhibition of threonine-tRNA ligase activity|inhibition of threonine-transfer ribonucleate synthetase activity|inhibition of threonyl ribonucleic synthetase activity|inhibition of threonyl-tRNA synthetase activity|inhibition of threonyl-transfer RNA synthetase activity|inhibition of threonyl-transfer ribonucleate synthetase activity|inhibition of threonyl-transfer ribonucleic acid synthetase activity|negative regulation of L-threonine:tRNAThr ligase (AMP-forming)|negative regulation of TRS|negative regulation of threonine translase activity|negative regulation of threonine-transfer ribonucleate synthetase activity|negative regulation of threonyl ribonucleic synthetase activity|negative regulation of threonyl-tRNA synthetase activity|negative regulation of threonyl-transfer RNA synthetase activity|negative regulation of threonyl-transfer ribonucleate synthetase activity|negative regulation of threonyl-transfer ribonucleic acid synthetase activity True http://purl.obolibrary.org/obo/GO_1905022 GO:1905023 biolink:BiologicalProcess positive regulation of threonine-tRNA ligase activity Any process that activates or increases the frequency, rate or extent of threonine-tRNA ligase activity. go.json activation of L-threonine:tRNAThr ligase (AMP-forming)|activation of TRS|activation of threonine translase activity|activation of threonine-tRNA ligase activity|activation of threonine-transfer ribonucleate synthetase activity|activation of threonyl ribonucleic synthetase activity|activation of threonyl-tRNA synthetase activity|activation of threonyl-transfer RNA synthetase activity|activation of threonyl-transfer ribonucleate synthetase activity|activation of threonyl-transfer ribonucleic acid synthetase activity|positive regulation of L-threonine:tRNAThr ligase (AMP-forming)|positive regulation of TRS|positive regulation of threonine translase activity|positive regulation of threonine-transfer ribonucleate synthetase activity|positive regulation of threonyl ribonucleic synthetase activity|positive regulation of threonyl-tRNA synthetase activity|positive regulation of threonyl-transfer RNA synthetase activity|positive regulation of threonyl-transfer ribonucleate synthetase activity|positive regulation of threonyl-transfer ribonucleic acid synthetase activity|up regulation of L-threonine:tRNAThr ligase (AMP-forming)|up regulation of TRS|up regulation of threonine translase activity|up regulation of threonine-tRNA ligase activity|up regulation of threonine-transfer ribonucleate synthetase activity|up regulation of threonyl ribonucleic synthetase activity|up regulation of threonyl-tRNA synthetase activity|up regulation of threonyl-transfer RNA synthetase activity|up regulation of threonyl-transfer ribonucleate synthetase activity|up regulation of threonyl-transfer ribonucleic acid synthetase activity|up-regulation of L-threonine:tRNAThr ligase (AMP-forming)|up-regulation of TRS|up-regulation of threonine translase activity|up-regulation of threonine-tRNA ligase activity|up-regulation of threonine-transfer ribonucleate synthetase activity|up-regulation of threonyl ribonucleic synthetase activity|up-regulation of threonyl-tRNA synthetase activity|up-regulation of threonyl-transfer RNA synthetase activity|up-regulation of threonyl-transfer ribonucleate synthetase activity|up-regulation of threonyl-transfer ribonucleic acid synthetase activity|upregulation of L-threonine:tRNAThr ligase (AMP-forming)|upregulation of TRS|upregulation of threonine translase activity|upregulation of threonine-tRNA ligase activity|upregulation of threonine-transfer ribonucleate synthetase activity|upregulation of threonyl ribonucleic synthetase activity|upregulation of threonyl-tRNA synthetase activity|upregulation of threonyl-transfer RNA synthetase activity|upregulation of threonyl-transfer ribonucleate synthetase activity|upregulation of threonyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_1905023 gocheck_do_not_annotate GO:1905024 biolink:BiologicalProcess regulation of membrane repolarization during ventricular cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. go.json regulation of electrocardiogram T wave|regulation of regulation of ventricular cardiac muscle repolarization|regulation of ventricular repolarization http://purl.obolibrary.org/obo/GO_1905024 GO:1905025 biolink:BiologicalProcess negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. go.json down regulation of electrocardiogram T wave|down regulation of membrane repolarization during ventricular cardiac muscle cell action potential|down regulation of regulation of ventricular cardiac muscle repolarization|down regulation of ventricular repolarization|down-regulation of electrocardiogram T wave|down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential|down-regulation of regulation of ventricular cardiac muscle repolarization|down-regulation of ventricular repolarization|downregulation of electrocardiogram T wave|downregulation of membrane repolarization during ventricular cardiac muscle cell action potential|downregulation of regulation of ventricular cardiac muscle repolarization|downregulation of ventricular repolarization|inhibition of electrocardiogram T wave|inhibition of membrane repolarization during ventricular cardiac muscle cell action potential|inhibition of regulation of ventricular cardiac muscle repolarization|inhibition of ventricular repolarization|negative regulation of electrocardiogram T wave|negative regulation of regulation of ventricular cardiac muscle repolarization|negative regulation of ventricular repolarization http://purl.obolibrary.org/obo/GO_1905025 GO:1905015 biolink:BiologicalProcess obsolete regulation of isoleucine-tRNA ligase activity OBSOLETE. Any process that modulates the frequency, rate or extent of isoleucine-tRNA ligase activity. go.json regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|regulation of isoleucine translase activity|regulation of isoleucine-tRNA synthetase activity|regulation of isoleucine-transfer RNA ligase activity|regulation of isoleucyl-tRNA synthetase activity|regulation of isoleucyl-transfer RNA synthetase activity|regulation of isoleucyl-transfer ribonucleate synthetase activity True http://purl.obolibrary.org/obo/GO_1905015 GO:0090459 biolink:BiologicalProcess intracellular aspartate homeostasis A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell. go.json aspartate homeostasis|cellular aspartate homeostasis http://purl.obolibrary.org/obo/GO_0090459 GO:1905016 biolink:BiologicalProcess obsolete negative regulation of isoleucine-tRNA ligase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of isoleucine-tRNA ligase activity. go.json down regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|down regulation of isoleucine translase activity|down regulation of isoleucine-tRNA ligase activity|down regulation of isoleucine-tRNA synthetase activity|down regulation of isoleucine-transfer RNA ligase activity|down regulation of isoleucyl-tRNA synthetase activity|down regulation of isoleucyl-transfer RNA synthetase activity|down regulation of isoleucyl-transfer ribonucleate synthetase activity|down-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|down-regulation of isoleucine translase activity|down-regulation of isoleucine-tRNA ligase activity|down-regulation of isoleucine-tRNA synthetase activity|down-regulation of isoleucine-transfer RNA ligase activity|down-regulation of isoleucyl-tRNA synthetase activity|down-regulation of isoleucyl-transfer RNA synthetase activity|down-regulation of isoleucyl-transfer ribonucleate synthetase activity|downregulation of L-isoleucine:tRNAIle ligase (AMP-forming)|downregulation of isoleucine translase activity|downregulation of isoleucine-tRNA ligase activity|downregulation of isoleucine-tRNA synthetase activity|downregulation of isoleucine-transfer RNA ligase activity|downregulation of isoleucyl-tRNA synthetase activity|downregulation of isoleucyl-transfer RNA synthetase activity|downregulation of isoleucyl-transfer ribonucleate synthetase activity|inhibition of L-isoleucine:tRNAIle ligase (AMP-forming)|inhibition of isoleucine translase activity|inhibition of isoleucine-tRNA ligase activity|inhibition of isoleucine-tRNA synthetase activity|inhibition of isoleucine-transfer RNA ligase activity|inhibition of isoleucyl-tRNA synthetase activity|inhibition of isoleucyl-transfer RNA synthetase activity|inhibition of isoleucyl-transfer ribonucleate synthetase activity|negative regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|negative regulation of isoleucine translase activity|negative regulation of isoleucine-tRNA synthetase activity|negative regulation of isoleucine-transfer RNA ligase activity|negative regulation of isoleucyl-tRNA synthetase activity|negative regulation of isoleucyl-transfer RNA synthetase activity|negative regulation of isoleucyl-transfer ribonucleate synthetase activity True http://purl.obolibrary.org/obo/GO_1905016 GO:1905017 biolink:BiologicalProcess positive regulation of isoleucine-tRNA ligase activity Any process that activates or increases the frequency, rate or extent of isoleucine-tRNA ligase activity. go.json activation of L-isoleucine:tRNAIle ligase (AMP-forming)|activation of isoleucine translase activity|activation of isoleucine-tRNA ligase activity|activation of isoleucine-tRNA synthetase activity|activation of isoleucine-transfer RNA ligase activity|activation of isoleucyl-tRNA synthetase activity|activation of isoleucyl-transfer RNA synthetase activity|activation of isoleucyl-transfer ribonucleate synthetase activity|positive regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|positive regulation of isoleucine translase activity|positive regulation of isoleucine-tRNA synthetase activity|positive regulation of isoleucine-transfer RNA ligase activity|positive regulation of isoleucyl-tRNA synthetase activity|positive regulation of isoleucyl-transfer RNA synthetase activity|positive regulation of isoleucyl-transfer ribonucleate synthetase activity|up regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|up regulation of isoleucine translase activity|up regulation of isoleucine-tRNA ligase activity|up regulation of isoleucine-tRNA synthetase activity|up regulation of isoleucine-transfer RNA ligase activity|up regulation of isoleucyl-tRNA synthetase activity|up regulation of isoleucyl-transfer RNA synthetase activity|up regulation of isoleucyl-transfer ribonucleate synthetase activity|up-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)|up-regulation of isoleucine translase activity|up-regulation of isoleucine-tRNA ligase activity|up-regulation of isoleucine-tRNA synthetase activity|up-regulation of isoleucine-transfer RNA ligase activity|up-regulation of isoleucyl-tRNA synthetase activity|up-regulation of isoleucyl-transfer RNA synthetase activity|up-regulation of isoleucyl-transfer ribonucleate synthetase activity|upregulation of L-isoleucine:tRNAIle ligase (AMP-forming)|upregulation of isoleucine translase activity|upregulation of isoleucine-tRNA ligase activity|upregulation of isoleucine-tRNA synthetase activity|upregulation of isoleucine-transfer RNA ligase activity|upregulation of isoleucyl-tRNA synthetase activity|upregulation of isoleucyl-transfer RNA synthetase activity|upregulation of isoleucyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_1905017 gocheck_do_not_annotate GO:0090457 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090457 GO:1905018 biolink:BiologicalProcess obsolete regulation of methionine-tRNA ligase activity OBSOLETE. Any process that modulates the frequency, rate or extent of methionine-tRNA ligase activity. go.json regulation of L-methionine:tRNAMet ligase (AMP-forming)|regulation of MetRS activity|regulation of methionine translase activity|regulation of methionyl-tRNA synthetase activity|regulation of methionyl-transfer RNA synthetase activity|regulation of methionyl-transfer ribonucleate synthetase activity|regulation of methionyl-transfer ribonucleic acid synthetase activity True http://purl.obolibrary.org/obo/GO_1905018 GO:0090458 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090458 GO:1905019 biolink:BiologicalProcess obsolete negative regulation of methionine-tRNA ligase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of methionine-tRNA ligase activity. go.json down regulation of L-methionine:tRNAMet ligase (AMP-forming)|down regulation of MetRS activity|down regulation of methionine translase activity|down regulation of methionine-tRNA ligase activity|down regulation of methionyl-tRNA synthetase activity|down regulation of methionyl-transfer RNA synthetase activity|down regulation of methionyl-transfer ribonucleate synthetase activity|down regulation of methionyl-transfer ribonucleic acid synthetase activity|down-regulation of L-methionine:tRNAMet ligase (AMP-forming)|down-regulation of MetRS activity|down-regulation of methionine translase activity|down-regulation of methionine-tRNA ligase activity|down-regulation of methionyl-tRNA synthetase activity|down-regulation of methionyl-transfer RNA synthetase activity|down-regulation of methionyl-transfer ribonucleate synthetase activity|down-regulation of methionyl-transfer ribonucleic acid synthetase activity|downregulation of L-methionine:tRNAMet ligase (AMP-forming)|downregulation of MetRS activity|downregulation of methionine translase activity|downregulation of methionine-tRNA ligase activity|downregulation of methionyl-tRNA synthetase activity|downregulation of methionyl-transfer RNA synthetase activity|downregulation of methionyl-transfer ribonucleate synthetase activity|downregulation of methionyl-transfer ribonucleic acid synthetase activity|inhibition of L-methionine:tRNAMet ligase (AMP-forming)|inhibition of MetRS activity|inhibition of methionine translase activity|inhibition of methionine-tRNA ligase activity|inhibition of methionyl-tRNA synthetase activity|inhibition of methionyl-transfer RNA synthetase activity|inhibition of methionyl-transfer ribonucleate synthetase activity|inhibition of methionyl-transfer ribonucleic acid synthetase activity|negative regulation of L-methionine:tRNAMet ligase (AMP-forming)|negative regulation of MetRS activity|negative regulation of methionine translase activity|negative regulation of methionyl-tRNA synthetase activity|negative regulation of methionyl-transfer RNA synthetase activity|negative regulation of methionyl-transfer ribonucleate synthetase activity|negative regulation of methionyl-transfer ribonucleic acid synthetase activity True http://purl.obolibrary.org/obo/GO_1905019 GO:0090451 biolink:BiologicalProcess cotyledon boundary formation The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained. go.json http://purl.obolibrary.org/obo/GO_0090451 GO:0090452 biolink:BiologicalProcess lithium ion transmembrane transport The directed movement of lithium ions across a membrane. go.json lithium ion import|lithium ion uptake http://purl.obolibrary.org/obo/GO_0090452 GO:0090450 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090450 GO:0090455 biolink:BiologicalProcess ornithine transmembrane import into vacuole The directed movement of ornithine into the vacuole across the vacuolar membrane. go.json vacuolar ornithine import http://purl.obolibrary.org/obo/GO_0090455 GO:0090456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090456 GO:0090453 biolink:BiologicalProcess aspartate transmembrane import into vacuole The directed movement of aspartate into the vacuole across the vacuolar membrane. go.json vacuolar aspartate import http://purl.obolibrary.org/obo/GO_0090453 GO:0090454 biolink:BiologicalProcess glutamate transmembrane import into vacuole The directed movement of glutamate into the vacuole across the vacuolar membrane. go.json vacuolar glutamate import http://purl.obolibrary.org/obo/GO_0090454 GO:1905030 biolink:MolecularActivity voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. go.json voltage gated ion channel activity involved in regulation of post-synaptic membrane potential|voltage gated ion channel activity involved in regulation of postsynaptic membrane potential|voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential|voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential|voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential|voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_1905030 goslim_synapse GO:1905031 biolink:BiologicalProcess regulation of membrane repolarization during cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. go.json http://purl.obolibrary.org/obo/GO_1905031 GO:1905032 biolink:BiologicalProcess negative regulation of membrane repolarization during cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. go.json down regulation of membrane repolarization during cardiac muscle cell action potential|down-regulation of membrane repolarization during cardiac muscle cell action potential|downregulation of membrane repolarization during cardiac muscle cell action potential|inhibition of membrane repolarization during cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1905032 GO:1905033 biolink:BiologicalProcess positive regulation of membrane repolarization during cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. go.json activation of membrane repolarization during cardiac muscle cell action potential|up regulation of membrane repolarization during cardiac muscle cell action potential|up-regulation of membrane repolarization during cardiac muscle cell action potential|upregulation of membrane repolarization during cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1905033 GO:1905034 biolink:BiologicalProcess regulation of antifungal innate immune response Any process that modulates the frequency, rate or extent of an antifungal innate immune response. go.json http://purl.obolibrary.org/obo/GO_1905034 GO:1905035 biolink:BiologicalProcess negative regulation of antifungal innate immune response Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response. go.json down regulation of antifungal innate immune response|down-regulation of antifungal innate immune response|downregulation of antifungal innate immune response|inhibition of antifungal innate immune response http://purl.obolibrary.org/obo/GO_1905035 GO:1905036 biolink:BiologicalProcess positive regulation of antifungal innate immune response Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response. go.json activation of antifungal innate immune response|up regulation of antifungal innate immune response|up-regulation of antifungal innate immune response|upregulation of antifungal innate immune response http://purl.obolibrary.org/obo/GO_1905036 GO:1905026 biolink:BiologicalProcess positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. go.json activation of electrocardiogram T wave|activation of membrane repolarization during ventricular cardiac muscle cell action potential|activation of regulation of ventricular cardiac muscle repolarization|activation of ventricular repolarization|positive regulation of electrocardiogram T wave|positive regulation of regulation of ventricular cardiac muscle repolarization|positive regulation of ventricular repolarization|up regulation of electrocardiogram T wave|up regulation of membrane repolarization during ventricular cardiac muscle cell action potential|up regulation of regulation of ventricular cardiac muscle repolarization|up regulation of ventricular repolarization|up-regulation of electrocardiogram T wave|up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential|up-regulation of regulation of ventricular cardiac muscle repolarization|up-regulation of ventricular repolarization|upregulation of electrocardiogram T wave|upregulation of membrane repolarization during ventricular cardiac muscle cell action potential|upregulation of regulation of ventricular cardiac muscle repolarization|upregulation of ventricular repolarization http://purl.obolibrary.org/obo/GO_1905026 GO:0090426 biolink:BiologicalProcess actin filament bundle convergence A process of actin filament bundle distribution that results in the compaction of actin filaments. go.json http://purl.obolibrary.org/obo/GO_0090426 GO:1905027 biolink:BiologicalProcess regulation of membrane depolarization during AV node cell action potential Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential. go.json regulation of membrane depolarization during AV node cardiac muscle cell action potential|regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1905027 GO:0090427 biolink:BiologicalProcess activation of meiosis Any process that starts the inactive process of meiosis. go.json http://purl.obolibrary.org/obo/GO_0090427 GO:1905028 biolink:BiologicalProcess negative regulation of membrane depolarization during AV node cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential. go.json down regulation of membrane depolarization during AV node cardiac muscle cell action potential|down regulation of membrane depolarization during AV node cell action potential|down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|down-regulation of membrane depolarization during AV node cardiac muscle cell action potential|down-regulation of membrane depolarization during AV node cell action potential|down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|downregulation of membrane depolarization during AV node cardiac muscle cell action potential|downregulation of membrane depolarization during AV node cell action potential|downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|inhibition of membrane depolarization during AV node cardiac muscle cell action potential|inhibition of membrane depolarization during AV node cell action potential|inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential|negative regulation of membrane depolarization during AV node cardiac muscle cell action potential|negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1905028 GO:0090424 biolink:BiologicalProcess phytochelatin-metal-sulfur complex formation A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex. go.json HWM phytochelatin complex formation|high molecular weight phytochelatin complex formation http://purl.obolibrary.org/obo/GO_0090424 GO:1905029 biolink:BiologicalProcess positive regulation of membrane depolarization during AV node cell action potential Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential. go.json activation of membrane depolarization during AV node cardiac muscle cell action potential|activation of membrane depolarization during AV node cell action potential|activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|positive regulation of membrane depolarization during AV node cardiac muscle cell action potential|positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|up regulation of membrane depolarization during AV node cardiac muscle cell action potential|up regulation of membrane depolarization during AV node cell action potential|up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|up-regulation of membrane depolarization during AV node cardiac muscle cell action potential|up-regulation of membrane depolarization during AV node cell action potential|up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential|upregulation of membrane depolarization during AV node cardiac muscle cell action potential|upregulation of membrane depolarization during AV node cell action potential|upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1905029 GO:0090425 biolink:BiologicalProcess acinar cell differentiation The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. go.json http://purl.obolibrary.org/obo/GO_0090425 GO:0090428 biolink:BiologicalProcess perianth development The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals. go.json http://purl.obolibrary.org/obo/GO_0090428 GO:0090429 biolink:BiologicalProcess detection of endogenous biotic stimulus The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0090429 GO:0090422 biolink:MolecularActivity thiamine pyrophosphate transmembrane transporter activity Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other. Reactome:R-HSA-8875838 go.json thiamine diphosphate transporter activity|thiamine pyrophosphate transporter activity http://purl.obolibrary.org/obo/GO_0090422 GO:0090423 biolink:BiologicalProcess phytochelatin-metal complex formation A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex. go.json LWM phytochelatin complex formation|low molecular weight phytochelatin complex formation http://purl.obolibrary.org/obo/GO_0090423 GO:0090420 biolink:BiologicalProcess obsolete naphthalene-containing compound metabolic process OBSOLETE. The chemical reactions and pathways involving naphthalene-containing compounds. go.json True http://purl.obolibrary.org/obo/GO_0090420 GO:0090421 biolink:BiologicalProcess embryonic meristem initiation Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. go.json http://purl.obolibrary.org/obo/GO_0090421 GO:1905040 biolink:BiologicalProcess otic placode development The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure. go.json auditory placode development|ear placode development|ear/otic placode development|octaval VIII placode development|octaval placode development|placoda otica development http://purl.obolibrary.org/obo/GO_1905040 GO:1905041 biolink:BiologicalProcess regulation of epithelium regeneration Any process that modulates the frequency, rate or extent of epithelium regeneration. go.json regulation of regeneration of epithelium http://purl.obolibrary.org/obo/GO_1905041 GO:1905042 biolink:BiologicalProcess negative regulation of epithelium regeneration Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration. go.json down regulation of epithelium regeneration|down regulation of regeneration of epithelium|down-regulation of epithelium regeneration|down-regulation of regeneration of epithelium|downregulation of epithelium regeneration|downregulation of regeneration of epithelium|inhibition of epithelium regeneration|inhibition of regeneration of epithelium|negative regulation of regeneration of epithelium http://purl.obolibrary.org/obo/GO_1905042 GO:1905043 biolink:BiologicalProcess positive regulation of epithelium regeneration Any process that activates or increases the frequency, rate or extent of epithelium regeneration. go.json activation of epithelium regeneration|activation of regeneration of epithelium|positive regulation of regeneration of epithelium|up regulation of epithelium regeneration|up regulation of regeneration of epithelium|up-regulation of epithelium regeneration|up-regulation of regeneration of epithelium|upregulation of epithelium regeneration|upregulation of regeneration of epithelium http://purl.obolibrary.org/obo/GO_1905043 GO:1905044 biolink:BiologicalProcess regulation of Schwann cell proliferation involved in axon regeneration Any process that modulates the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration. go.json http://purl.obolibrary.org/obo/GO_1905044 GO:1905045 biolink:BiologicalProcess negative regulation of Schwann cell proliferation involved in axon regeneration Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration. go.json down regulation of Schwann cell proliferation involved in axon regeneration|down-regulation of Schwann cell proliferation involved in axon regeneration|downregulation of Schwann cell proliferation involved in axon regeneration|inhibition of Schwann cell proliferation involved in axon regeneration http://purl.obolibrary.org/obo/GO_1905045 GO:1905046 biolink:BiologicalProcess positive regulation of Schwann cell proliferation involved in axon regeneration Any process that activates or increases the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration. go.json activation of Schwann cell proliferation involved in axon regeneration|up regulation of Schwann cell proliferation involved in axon regeneration|up-regulation of Schwann cell proliferation involved in axon regeneration|upregulation of Schwann cell proliferation involved in axon regeneration http://purl.obolibrary.org/obo/GO_1905046 GO:1905047 biolink:BiologicalProcess mitotic spindle pole body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_1905047 GO:0090437 biolink:BiologicalProcess socket cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support. go.json http://purl.obolibrary.org/obo/GO_0090437 GO:1905037 biolink:BiologicalProcess autophagosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. go.json autophagic vacuole organization|initial autophagic vacuole organization http://purl.obolibrary.org/obo/GO_1905037 GO:1905038 biolink:BiologicalProcess regulation of membrane lipid metabolic process Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. go.json regulation of membrane lipid metabolism http://purl.obolibrary.org/obo/GO_1905038 GO:0090438 biolink:MolecularActivity camelliol C synthase activity Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C. go.json (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming) http://purl.obolibrary.org/obo/GO_0090438 GO:0090435 biolink:BiologicalProcess protein localization to nuclear envelope A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. go.json protein localization in nuclear envelope http://purl.obolibrary.org/obo/GO_0090435 GO:1905039 biolink:BiologicalProcess carboxylic acid transmembrane transport The process in which carboxylic acid is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1905039 GO:0090436 biolink:BiologicalProcess leaf pavement cell development The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate. go.json http://purl.obolibrary.org/obo/GO_0090436 GO:0090439 biolink:MolecularActivity tetraketide alpha-pyrone synthase activity Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A . go.json http://purl.obolibrary.org/obo/GO_0090439 GO:0090430 biolink:MolecularActivity caffeoyl-CoA: alcohol caffeoyl transferase activity Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA. go.json http://purl.obolibrary.org/obo/GO_0090430 GO:0090433 biolink:MolecularActivity palmitoyl-CoA ligase activity Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA. Reactome:R-HSA-434382 go.json palmitoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0090433 GO:0090434 biolink:MolecularActivity oleoyl-CoA ligase activity Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA. go.json oleoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0090434 GO:0090431 biolink:BiologicalProcess alkyl caffeate ester biosynthetic process The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate. go.json alkyl caffeate ester anabolism|alkyl caffeate ester biosynthesis|alkyl caffeate ester formation|alkyl caffeate ester synthesis http://purl.obolibrary.org/obo/GO_0090431 GO:0090432 biolink:MolecularActivity myristoyl-CoA ligase activity Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA. go.json myristoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0090432 GO:0090480 biolink:BiologicalProcess purine nucleotide-sugar transmembrane transport The process in which a purine nucleotide-sugar is transported across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json purine nucleotide-sugar membrane transport|purine nucleotide-sugar transport http://purl.obolibrary.org/obo/GO_0090480 GO:0090481 biolink:BiologicalProcess pyrimidine nucleotide-sugar transmembrane transport The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json pyrimidine nucleotide-sugar membrane transport|pyrimidine nucleotide-sugar transport http://purl.obolibrary.org/obo/GO_0090481 GO:1905050 biolink:BiologicalProcess positive regulation of metallopeptidase activity Any process that activates or increases the frequency, rate or extent of metallopeptidase activity. go.json activation of metallopeptidase activity|activation of metalloprotease activity|activation of metalloproteinase activity|positive regulation of metalloprotease activity|positive regulation of metalloproteinase activity|up regulation of metallopeptidase activity|up regulation of metalloprotease activity|up regulation of metalloproteinase activity|up-regulation of metallopeptidase activity|up-regulation of metalloprotease activity|up-regulation of metalloproteinase activity|upregulation of metallopeptidase activity|upregulation of metalloprotease activity|upregulation of metalloproteinase activity http://purl.obolibrary.org/obo/GO_1905050 gocheck_do_not_annotate GO:1905051 biolink:BiologicalProcess regulation of base-excision repair Any process that modulates the frequency, rate or extent of base-excision repair. go.json regulation of BER http://purl.obolibrary.org/obo/GO_1905051 GO:1905052 biolink:BiologicalProcess negative regulation of base-excision repair Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair. go.json down regulation of BER|down regulation of base-excision repair|down-regulation of BER|down-regulation of base-excision repair|downregulation of BER|downregulation of base-excision repair|inhibition of BER|inhibition of base-excision repair|negative regulation of BER http://purl.obolibrary.org/obo/GO_1905052 GO:1905053 biolink:BiologicalProcess positive regulation of base-excision repair Any process that activates or increases the frequency, rate or extent of base-excision repair. go.json activation of BER|activation of base-excision repair|positive regulation of BER|up regulation of BER|up regulation of base-excision repair|up-regulation of BER|up-regulation of base-excision repair|upregulation of BER|upregulation of base-excision repair http://purl.obolibrary.org/obo/GO_1905053 GO:1905054 biolink:MolecularActivity calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. go.json calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_1905054 goslim_synapse GO:1905055 biolink:MolecularActivity calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. go.json calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels|calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_1905055 goslim_synapse GO:1905056 biolink:MolecularActivity P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration. go.json ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration|ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels|Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration|calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration|calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_1905056 goslim_synapse GO:1905057 biolink:MolecularActivity voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. go.json depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration|depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration|depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration|dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration|voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration|voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration|voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels|voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration|voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_1905057 goslim_synapse GO:1905058 biolink:MolecularActivity calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. go.json calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_1905058 goslim_synapse GO:1905048 biolink:BiologicalProcess regulation of metallopeptidase activity Any process that modulates the frequency, rate or extent of metallopeptidase activity. go.json regulation of metalloprotease activity|regulation of metalloproteinase activity http://purl.obolibrary.org/obo/GO_1905048 gocheck_do_not_annotate GO:1905049 biolink:BiologicalProcess negative regulation of metallopeptidase activity Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity. go.json down regulation of metallopeptidase activity|down regulation of metalloprotease activity|down regulation of metalloproteinase activity|down-regulation of metallopeptidase activity|down-regulation of metalloprotease activity|down-regulation of metalloproteinase activity|downregulation of metallopeptidase activity|downregulation of metalloprotease activity|downregulation of metalloproteinase activity|inhibition of metallopeptidase activity|inhibition of metalloprotease activity|inhibition of metalloproteinase activity|negative regulation of metalloprotease activity|negative regulation of metalloproteinase activity http://purl.obolibrary.org/obo/GO_1905049 gocheck_do_not_annotate GO:0090484 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090484 GO:0090485 biolink:BiologicalProcess obsolete chromosome number maintenance OBSOLETE. The maintenance of the standard number of chromosomes in a cell. go.json diploidization|haploidization True http://purl.obolibrary.org/obo/GO_0090485 GO:0090482 biolink:MolecularActivity vitamin transmembrane transporter activity Enables the transfer of a vitamin from one side of a membrane to the other. go.json vitamin or cofactor transporter activity|vitamin transporter activity http://purl.obolibrary.org/obo/GO_0090482 GO:0090483 biolink:MolecularActivity phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine. go.json cardiolipin synthase http://purl.obolibrary.org/obo/GO_0090483 GO:0090488 biolink:MolecularActivity polo box domain specific binding Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases. go.json http://purl.obolibrary.org/obo/GO_0090488 GO:0090489 biolink:MolecularActivity L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O. go.json tryptophan N-monooxygenase activity http://purl.obolibrary.org/obo/GO_0090489 GO:0090486 biolink:MolecularActivity small RNA 2'-O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide. EC:2.1.1.386|RHEA:37887 go.json small RNA 2'-O-methyltransferase http://purl.obolibrary.org/obo/GO_0090486 GO:0090487 biolink:BiologicalProcess secondary metabolite catabolic process The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. go.json secondary metabolite breakdown|secondary metabolite catabolism|secondary metabolite degradation http://purl.obolibrary.org/obo/GO_0090487 GO:0090491 biolink:MolecularActivity N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0090491 GO:0090492 biolink:MolecularActivity N,N-Dihydroxy-L-tryptophan decarboxylase activity Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O. go.json http://purl.obolibrary.org/obo/GO_0090492 GO:1905060 biolink:MolecularActivity calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. go.json calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels http://purl.obolibrary.org/obo/GO_1905060 goslim_synapse GO:1905061 biolink:BiologicalProcess negative regulation of cardioblast proliferation Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast proliferation. go.json down regulation of cardioblast proliferation|down-regulation of cardioblast proliferation|downregulation of cardioblast proliferation|inhibition of cardioblast proliferation http://purl.obolibrary.org/obo/GO_1905061 GO:0090490 biolink:MolecularActivity L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0090490 GO:1905062 biolink:BiologicalProcess positive regulation of cardioblast proliferation Any process that activates or increases the frequency, rate or extent of cardioblast proliferation. go.json activation of cardioblast proliferation|up regulation of cardioblast proliferation|up-regulation of cardioblast proliferation|upregulation of cardioblast proliferation http://purl.obolibrary.org/obo/GO_1905062 GO:1905063 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. go.json regulation of VSMC differentiation|regulation of vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_1905063 GO:1905064 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. go.json down regulation of VSMC differentiation|down regulation of vascular associated smooth muscle cell differentiation|down regulation of vascular smooth muscle cell differentiation|down-regulation of VSMC differentiation|down-regulation of vascular associated smooth muscle cell differentiation|down-regulation of vascular smooth muscle cell differentiation|downregulation of VSMC differentiation|downregulation of vascular associated smooth muscle cell differentiation|downregulation of vascular smooth muscle cell differentiation|inhibition of VSMC differentiation|inhibition of vascular associated smooth muscle cell differentiation|inhibition of vascular smooth muscle cell differentiation|negative regulation of VSMC differentiation|negative regulation of vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_1905064 GO:1905065 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. go.json activation of VSMC differentiation|activation of vascular associated smooth muscle cell differentiation|activation of vascular smooth muscle cell differentiation|positive regulation of VSMC differentiation|positive regulation of vascular smooth muscle cell differentiation|up regulation of VSMC differentiation|up regulation of vascular associated smooth muscle cell differentiation|up regulation of vascular smooth muscle cell differentiation|up-regulation of VSMC differentiation|up-regulation of vascular associated smooth muscle cell differentiation|up-regulation of vascular smooth muscle cell differentiation|upregulation of VSMC differentiation|upregulation of vascular associated smooth muscle cell differentiation|upregulation of vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_1905065 GO:1905066 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway involved in heart development Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. go.json regulation of canonical Wnt receptor signaling pathway involved in heart development|regulation of canonical Wnt receptor signalling pathway involved in heart development|regulation of canonical Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_1905066 GO:1905067 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway involved in heart development Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. go.json down regulation of canonical Wnt receptor signaling pathway involved in heart development|down regulation of canonical Wnt receptor signalling pathway involved in heart development|down regulation of canonical Wnt signaling pathway involved in heart development|down regulation of canonical Wnt-activated signaling pathway involved in heart development|down-regulation of canonical Wnt receptor signaling pathway involved in heart development|down-regulation of canonical Wnt receptor signalling pathway involved in heart development|down-regulation of canonical Wnt signaling pathway involved in heart development|down-regulation of canonical Wnt-activated signaling pathway involved in heart development|downregulation of canonical Wnt receptor signaling pathway involved in heart development|downregulation of canonical Wnt receptor signalling pathway involved in heart development|downregulation of canonical Wnt signaling pathway involved in heart development|downregulation of canonical Wnt-activated signaling pathway involved in heart development|inhibition of canonical Wnt receptor signaling pathway involved in heart development|inhibition of canonical Wnt receptor signalling pathway involved in heart development|inhibition of canonical Wnt signaling pathway involved in heart development|inhibition of canonical Wnt-activated signaling pathway involved in heart development|negative regulation of canonical Wnt receptor signaling pathway involved in heart development|negative regulation of canonical Wnt receptor signalling pathway involved in heart development|negative regulation of canonical Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_1905067 GO:1905068 biolink:BiologicalProcess positive regulation of canonical Wnt signaling pathway involved in heart development Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. go.json activation of canonical Wnt receptor signaling pathway involved in heart development|activation of canonical Wnt receptor signalling pathway involved in heart development|activation of canonical Wnt signaling pathway involved in heart development|activation of canonical Wnt-activated signaling pathway involved in heart development|positive regulation of canonical Wnt receptor signaling pathway involved in heart development|positive regulation of canonical Wnt receptor signalling pathway involved in heart development|positive regulation of canonical Wnt-activated signaling pathway involved in heart development|up regulation of canonical Wnt receptor signaling pathway involved in heart development|up regulation of canonical Wnt receptor signalling pathway involved in heart development|up regulation of canonical Wnt signaling pathway involved in heart development|up regulation of canonical Wnt-activated signaling pathway involved in heart development|up-regulation of canonical Wnt receptor signaling pathway involved in heart development|up-regulation of canonical Wnt receptor signalling pathway involved in heart development|up-regulation of canonical Wnt signaling pathway involved in heart development|up-regulation of canonical Wnt-activated signaling pathway involved in heart development|upregulation of canonical Wnt receptor signaling pathway involved in heart development|upregulation of canonical Wnt receptor signalling pathway involved in heart development|upregulation of canonical Wnt signaling pathway involved in heart development|upregulation of canonical Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_1905068 GO:1905069 biolink:BiologicalProcess allantois development The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure. go.json allantoic bud development http://purl.obolibrary.org/obo/GO_1905069 GO:1905059 biolink:MolecularActivity P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration. go.json ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration|ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels|Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels|plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration|sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration|sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_1905059 goslim_synapse GO:0090495 biolink:BiologicalProcess low-density lipoprotein particle disassembly The disaggregation of a low-density lipoprotein particle into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0090495 GO:0090496 biolink:BiologicalProcess mesenchyme migration involved in limb bud formation The migration of mesenchymal tissue that contributes to the formation of a limb bud. go.json http://purl.obolibrary.org/obo/GO_0090496 GO:0090493 biolink:BiologicalProcess catecholamine uptake The directed movement of catecholamine into a cell. go.json http://purl.obolibrary.org/obo/GO_0090493 GO:0090494 biolink:BiologicalProcess dopamine uptake The directed movement of dopamine into a cell. go.json http://purl.obolibrary.org/obo/GO_0090494 GO:0090499 biolink:MolecularActivity pimelyl-[acyl-carrier protein] methyl ester esterase activity Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol. go.json pimelyl-[acyl-carrier protein] methyl ester hydrolase activity http://purl.obolibrary.org/obo/GO_0090499 GO:0090497 biolink:BiologicalProcess mesenchymal cell migration The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0090497 GO:0090498 biolink:CellularComponent extrinsic component of Golgi membrane The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to Golgi membrane http://purl.obolibrary.org/obo/GO_0090498 GO:0016490 biolink:MolecularActivity structural constituent of peritrophic membrane The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster. go.json structural constituent of peritrophic matrix http://purl.obolibrary.org/obo/GO_0016490 GO:1905070 biolink:BiologicalProcess anterior visceral endoderm cell migration The orderly movement of an anterior visceral endoderm cell from one site to another. go.json http://purl.obolibrary.org/obo/GO_1905070 GO:1905071 biolink:BiologicalProcess tight junction disassembly The disaggregation of an tight junction into its constituent components. go.json occluding cell junction disassembly|occluding junction disassembly http://purl.obolibrary.org/obo/GO_1905071 GO:1905072 biolink:BiologicalProcess cardiac jelly development The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure. The cardiac jelly is an acellular gelatinous matrix secreted by the myocardium and plays a central role in the septation of the heart. go.json heart cardiac jelly development http://purl.obolibrary.org/obo/GO_1905072 GO:1905073 biolink:BiologicalProcess regulation of tight junction disassembly Any process that modulates the frequency, rate or extent of tight junction disassembly. go.json regulation of occluding cell junction disassembly|regulation of occluding junction disassembly http://purl.obolibrary.org/obo/GO_1905073 GO:1905074 biolink:BiologicalProcess negative regulation of tight junction disassembly Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly. go.json down regulation of occluding cell junction disassembly|down regulation of tight junction disassembly|down-regulation of occluding cell junction disassembly|down-regulation of tight junction disassembly|downregulation of occluding cell junction disassembly|downregulation of occluding junction disassembly|downregulation of tight junction disassembly|inhibition of occluding cell junction disassembly|inhibition of occluding junction disassembly|inhibition of tight junction disassembly|negative regulation of occluding cell junction disassembly http://purl.obolibrary.org/obo/GO_1905074 GO:1905075 biolink:BiologicalProcess positive regulation of tight junction disassembly Any process that activates or increases the frequency, rate or extent of tight junction disassembly. go.json activation of occluding cell junction disassembly|activation of occluding junction disassembly|activation of tight junction disassembly|positive regulation of occluding cell junction disassembly|positive regulation of occluding junction disassembly|up regulation of occluding cell junction disassembly|up regulation of tight junction disassembly|up-regulation of occluding cell junction disassembly|up-regulation of tight junction disassembly|upregulation of occluding cell junction disassembly|upregulation of tight junction disassembly http://purl.obolibrary.org/obo/GO_1905075 GO:1905076 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905076 GO:1905077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905077 GO:1905078 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905078 GO:1905079 biolink:BiologicalProcess regulation of cerebellar neuron development Any process that modulates the frequency, rate or extent of cerebellar neuron development. go.json http://purl.obolibrary.org/obo/GO_1905079 GO:0090468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090468 GO:0090469 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090469 GO:0016488 biolink:BiologicalProcess farnesol catabolic process The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. go.json farnesol breakdown|farnesol catabolism|farnesol degradation http://purl.obolibrary.org/obo/GO_0016488 GO:0016489 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016489 GO:0016484 biolink:MolecularActivity obsolete proprotein convertase 2 activator activity OBSOLETE. Required for the maturation and activation of proprotein convertase 2. go.json proprotein convertase 2 activator activity True http://purl.obolibrary.org/obo/GO_0016484 GO:0090462 biolink:BiologicalProcess intracellular ornithine homeostasis A homeostatic process involved in the maintenance of a steady state level of orthinine within a cell. go.json cellular ornithine homeostasis|ornithine homeostasis http://purl.obolibrary.org/obo/GO_0090462 GO:0090463 biolink:BiologicalProcess intracellular lysine homeostasis A homeostatic process involved in the maintenance of a steady state level of lysine within a cell. go.json cellular lysine homeostasis|lysine homeostasis http://purl.obolibrary.org/obo/GO_0090463 GO:0016485 biolink:BiologicalProcess protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. go.json peptidolysis during protein maturation|protein maturation by peptide bond cleavage|protein maturation by peptide bond hydrolysis|protein maturation by proteolysis http://purl.obolibrary.org/obo/GO_0016485 goslim_chembl GO:0090460 biolink:BiologicalProcess intracellular threonine homeostasis A homeostatic process involved in the maintenance of a steady state level of threonine within a cell. go.json cellular threonine homeostasis|threonine homeostasis http://purl.obolibrary.org/obo/GO_0090460 GO:0016486 biolink:BiologicalProcess peptide hormone processing The generation of a mature peptide hormone by posttranslational processing of a prohormone. go.json http://purl.obolibrary.org/obo/GO_0016486 GO:0090461 biolink:BiologicalProcess intracellular glutamate homeostasis A homeostatic process involved in the maintenance of a steady state level of glutamate within a cell. go.json cellular glutamate homeostasis|glutamate homeostasis http://purl.obolibrary.org/obo/GO_0090461 GO:0016487 biolink:BiologicalProcess farnesol metabolic process The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. go.json farnesol metabolism http://purl.obolibrary.org/obo/GO_0016487 GO:0016480 biolink:BiologicalProcess negative regulation of transcription by RNA polymerase III Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III. go.json down regulation of transcription from RNA polymerase III promoter|down-regulation of transcription from RNA polymerase III promoter|downregulation of transcription from RNA polymerase III promoter|inhibition of transcription from RNA polymerase III promoter|negative regulation of transcription from Pol III promoter|negative regulation of transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0016480 GO:0090466 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090466 GO:0016481 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016481 GO:0090467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090467 GO:0090464 biolink:BiologicalProcess intracellular histidine homeostasis A homeostatic process involved in the maintenance of a steady state level of histidine within a cell. go.json cellular histidine homeostasis|histidine homeostasis http://purl.obolibrary.org/obo/GO_0090464 GO:0016482 biolink:BiologicalProcess cytosolic transport The directed movement of substances or organelles within the cytosol. go.json http://purl.obolibrary.org/obo/GO_0016482 GO:0090465 biolink:BiologicalProcess intracellular arginine homeostasis A homeostatic process involved in the maintenance of a steady state level of arginine within a cell. go.json arginine homeostasis|cellular arginine homeostasis http://purl.obolibrary.org/obo/GO_0090465 GO:0016483 biolink:MolecularActivity tryptophan hydroxylase activator activity Increases the activity of the enzyme tryptophase hydroxylase. go.json http://purl.obolibrary.org/obo/GO_0016483 GO:1905080 biolink:BiologicalProcess negative regulation of cerebellar neuron development Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development. go.json down regulation of cerebellar neuron development|down-regulation of cerebellar neuron development|downregulation of cerebellar neuron development|inhibition of cerebellar neuron development http://purl.obolibrary.org/obo/GO_1905080 GO:0090470 biolink:BiologicalProcess shoot organ boundary specification The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained. go.json http://purl.obolibrary.org/obo/GO_0090470 GO:1905081 biolink:BiologicalProcess positive regulation of cerebellar neuron development Any process that activates or increases the frequency, rate or extent of cerebellar neuron development. go.json activation of cerebellar neuron development|up regulation of cerebellar neuron development|up-regulation of cerebellar neuron development|upregulation of cerebellar neuron development http://purl.obolibrary.org/obo/GO_1905081 GO:1905082 biolink:BiologicalProcess regulation of mitochondrial translational elongation Any process that modulates the frequency, rate or extent of mitochondrial translational elongation. go.json regulation of mitochondrial translation elongation http://purl.obolibrary.org/obo/GO_1905082 GO:1905083 biolink:BiologicalProcess negative regulation of mitochondrial translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation. go.json down regulation of mitochondrial translation elongation|down regulation of mitochondrial translational elongation|down-regulation of mitochondrial translation elongation|down-regulation of mitochondrial translational elongation|downregulation of mitochondrial translation elongation|downregulation of mitochondrial translational elongation|inhibition of mitochondrial translation elongation|inhibition of mitochondrial translational elongation|negative regulation of mitochondrial translation elongation http://purl.obolibrary.org/obo/GO_1905083 GO:1905084 biolink:BiologicalProcess positive regulation of mitochondrial translational elongation Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation. go.json activation of mitochondrial translation elongation|activation of mitochondrial translational elongation|positive regulation of mitochondrial translation elongation|up regulation of mitochondrial translation elongation|up regulation of mitochondrial translational elongation|up-regulation of mitochondrial translation elongation|up-regulation of mitochondrial translational elongation|upregulation of mitochondrial translation elongation|upregulation of mitochondrial translational elongation http://purl.obolibrary.org/obo/GO_1905084 GO:1905085 biolink:BiologicalProcess regulation of bioluminescence Any process that modulates the frequency, rate or extent of bioluminescence. go.json http://purl.obolibrary.org/obo/GO_1905085 GO:1905086 biolink:BiologicalProcess negative regulation of bioluminescence Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence. go.json down regulation of bioluminescence|down-regulation of bioluminescence|downregulation of bioluminescence|inhibition of bioluminescence http://purl.obolibrary.org/obo/GO_1905086 GO:1905087 biolink:BiologicalProcess positive regulation of bioluminescence Any process that activates or increases the frequency, rate or extent of bioluminescence. go.json activation of bioluminescence|up regulation of bioluminescence|up-regulation of bioluminescence|upregulation of bioluminescence http://purl.obolibrary.org/obo/GO_1905087 GO:1905088 biolink:BiologicalProcess positive regulation of synaptonemal complex assembly Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly. go.json activation of synaptonemal complex assembly|activation of synaptonemal complex formation|positive regulation of synaptonemal complex formation|up regulation of synaptonemal complex assembly|up regulation of synaptonemal complex formation|up-regulation of synaptonemal complex assembly|up-regulation of synaptonemal complex formation|upregulation of synaptonemal complex assembly|upregulation of synaptonemal complex formation http://purl.obolibrary.org/obo/GO_1905088 GO:1905089 biolink:BiologicalProcess regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization Any process that modulates the frequency, rate or extent of a parkin-mediated process that positively regulates mitophagy in response to mitochondrial depolarization. go.json regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization|regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_1905089 GO:0090479 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090479 GO:0016499 biolink:MolecularActivity orexin receptor activity Combining with orexin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0016499 GO:0016495 biolink:MolecularActivity C-X3-C chemokine receptor activity Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. go.json http://purl.obolibrary.org/obo/GO_0016495 GO:0090473 biolink:BiologicalProcess lys-arg specific dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein. go.json http://purl.obolibrary.org/obo/GO_0090473 GO:0016496 biolink:MolecularActivity substance P receptor activity Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0016496 GO:0090474 biolink:BiologicalProcess arg-arg specific dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein. go.json http://purl.obolibrary.org/obo/GO_0090474 GO:0090471 biolink:MolecularActivity 9,15,9'-tri-cis-zeta-carotene isomerase activity Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene. go.json 9,15,9'-tricis-zeta-carotene cis-trans-isomerase http://purl.obolibrary.org/obo/GO_0090471 GO:0016497 biolink:MolecularActivity substance K receptor activity Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. go.json neurokinin A receptor activity|neuromedin L receptor activity http://purl.obolibrary.org/obo/GO_0016497 GO:0016498 biolink:MolecularActivity neuromedin K receptor activity Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity. go.json neurokinin B receptor activity http://purl.obolibrary.org/obo/GO_0016498 GO:0090472 biolink:BiologicalProcess dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein. go.json http://purl.obolibrary.org/obo/GO_0090472 GO:0016491 biolink:MolecularActivity oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. EC:1.-.-.-|Reactome:R-HSA-1614362|Reactome:R-HSA-209921|Reactome:R-HSA-209960|Reactome:R-HSA-3095889|Reactome:R-HSA-390425|Reactome:R-HSA-390438|Reactome:R-HSA-5662660|Reactome:R-HSA-8878581|Reactome:R-HSA-8936442|Reactome:R-HSA-9020249|Reactome:R-HSA-9020260|Reactome:R-HSA-9024624|Reactome:R-HSA-9024630|Reactome:R-HSA-9025007|Reactome:R-HSA-9026001|Reactome:R-HSA-9026917|Reactome:R-HSA-9027033|Reactome:R-HSA-9693722 go.json oxidoreductase activity, acting on other substrates|redox activity http://purl.obolibrary.org/obo/GO_0016491 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_yeast|prokaryote_subset GO:0090477 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090477 GO:0090478 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090478 GO:0016492 biolink:MolecularActivity G protein-coupled neurotensin receptor activity Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. go.json G protein coupled neurotensin receptor activity|G-protein coupled neurotensin receptor activity|neurotensin receptor activity, G protein coupled|neurotensin receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0016492 GO:0090475 biolink:BiologicalProcess lys-lys specific dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein. go.json http://purl.obolibrary.org/obo/GO_0090475 GO:0016493 biolink:MolecularActivity C-C chemokine receptor activity Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. go.json http://purl.obolibrary.org/obo/GO_0016493 GO:0090476 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090476 GO:0016494 biolink:MolecularActivity C-X-C chemokine receptor activity Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. go.json http://purl.obolibrary.org/obo/GO_0016494 GO:2000409 biolink:BiologicalProcess positive regulation of T cell extravasation Any process that activates or increases the frequency, rate or extent of T cell extravasation. go.json positive regulation of T lymphocyte extravasation|positive regulation of T-cell extravasation|positive regulation of T-lymphocyte extravasation http://purl.obolibrary.org/obo/GO_2000409 GO:2000401 biolink:BiologicalProcess regulation of lymphocyte migration Any process that modulates the frequency, rate or extent of lymphocyte migration. go.json http://purl.obolibrary.org/obo/GO_2000401 GO:2000402 biolink:BiologicalProcess negative regulation of lymphocyte migration Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. go.json http://purl.obolibrary.org/obo/GO_2000402 GO:2000403 biolink:BiologicalProcess positive regulation of lymphocyte migration Any process that activates or increases the frequency, rate or extent of lymphocyte migration. go.json http://purl.obolibrary.org/obo/GO_2000403 GO:2000404 biolink:BiologicalProcess regulation of T cell migration Any process that modulates the frequency, rate or extent of T cell migration. go.json regulation of T lymphocyte migration|regulation of T-cell migration|regulation of T-lymphocyte migration http://purl.obolibrary.org/obo/GO_2000404 GO:2000405 biolink:BiologicalProcess negative regulation of T cell migration Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. go.json negative regulation of T lymphocyte migration|negative regulation of T-cell migration|negative regulation of T-lymphocyte migration http://purl.obolibrary.org/obo/GO_2000405 GO:2000406 biolink:BiologicalProcess positive regulation of T cell migration Any process that activates or increases the frequency, rate or extent of T cell migration. go.json positive regulation of T lymphocyte migration|positive regulation of T-cell migration|positive regulation of T-lymphocyte migration http://purl.obolibrary.org/obo/GO_2000406 GO:2000407 biolink:BiologicalProcess regulation of T cell extravasation Any process that modulates the frequency, rate or extent of T cell extravasation. go.json regulation of T lymphocyte extravasation|regulation of T-cell extravasation|regulation of T-lymphocyte extravasation http://purl.obolibrary.org/obo/GO_2000407 GO:2000408 biolink:BiologicalProcess negative regulation of T cell extravasation Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation. go.json negative regulation of T lymphocyte extravasation|negative regulation of T-cell extravasation|negative regulation of T-lymphocyte extravasation http://purl.obolibrary.org/obo/GO_2000408 GO:2000400 biolink:BiologicalProcess positive regulation of thymocyte aggregation Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. go.json positive regulation of T cell precursor aggregation|positive regulation of immature T cell aggregation|positive regulation of immature T-cell aggregation|positive regulation of immature T-lymphocyte aggregation|positive regulation of thymic lymphocyte aggregation http://purl.obolibrary.org/obo/GO_2000400 GO:2000412 biolink:BiologicalProcess positive regulation of thymocyte migration Any process that activates or increases the frequency, rate or extent of thymocyte migration. go.json positive regulation of immature T cell migration|positive regulation of immature T lymphocyte migration|positive regulation of immature T-cell migration|positive regulation of immature T-lymphocyte migration|positive regulation of thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_2000412 GO:2000413 biolink:BiologicalProcess regulation of fibronectin-dependent thymocyte migration Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration. go.json regulation of fibronectin-dependent immature T cell migration|regulation of fibronectin-dependent immature T lymphocyte migration|regulation of fibronectin-dependent immature T-cell migration|regulation of fibronectin-dependent immature T-lymphocyte migration|regulation of fibronectin-dependent thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_2000413 GO:2000414 biolink:BiologicalProcess negative regulation of fibronectin-dependent thymocyte migration Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration. go.json negative regulation of fibronectin-dependent immature T cell migration|negative regulation of fibronectin-dependent immature T lymphocyte migration|negative regulation of fibronectin-dependent immature T-cell migration|negative regulation of fibronectin-dependent immature T-lymphocyte migration|negative regulation of fibronectin-dependent thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_2000414 GO:2000415 biolink:BiologicalProcess positive regulation of fibronectin-dependent thymocyte migration Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration. go.json positive regulation of fibronectin-dependent immature T cell migration|positive regulation of fibronectin-dependent immature T lymphocyte migration|positive regulation of fibronectin-dependent immature T-cell migration|positive regulation of fibronectin-dependent immature T-lymphocyte migration|positive regulation of fibronectin-dependent thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_2000415 GO:2000416 biolink:BiologicalProcess regulation of eosinophil migration Any process that modulates the frequency, rate or extent of eosinophil migration. go.json http://purl.obolibrary.org/obo/GO_2000416 GO:2000417 biolink:BiologicalProcess negative regulation of eosinophil migration Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration. go.json http://purl.obolibrary.org/obo/GO_2000417 GO:2000418 biolink:BiologicalProcess positive regulation of eosinophil migration Any process that activates or increases the frequency, rate or extent of eosinophil migration. go.json http://purl.obolibrary.org/obo/GO_2000418 GO:2000419 biolink:BiologicalProcess regulation of eosinophil extravasation Any process that modulates the frequency, rate or extent of eosinophil extravasation. go.json http://purl.obolibrary.org/obo/GO_2000419 GO:2000410 biolink:BiologicalProcess regulation of thymocyte migration Any process that modulates the frequency, rate or extent of thymocyte migration. go.json regulation of immature T cell migration|regulation of immature T lymphocyte migration|regulation of immature T-cell migration|regulation of immature T-lymphocyte migration|regulation of thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_2000410 GO:2000411 biolink:BiologicalProcess negative regulation of thymocyte migration Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration. go.json negative regulation of immature T cell migration|negative regulation of immature T lymphocyte migration|negative regulation of immature T-cell migration|negative regulation of immature T-lymphocyte migration|negative regulation of thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_2000411 GO:0090404 biolink:CellularComponent pollen tube tip The region at growing end of the pollen tube cell, where polarized growth occurs. go.json http://purl.obolibrary.org/obo/GO_0090404 GO:0090405 biolink:CellularComponent unicellular trichome branch A cell projection part that is a branch of a unicellular trichome. go.json http://purl.obolibrary.org/obo/GO_0090405 GO:0090402 biolink:BiologicalProcess oncogene-induced cell senescence A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family. go.json OIS http://purl.obolibrary.org/obo/GO_0090402 GO:0090403 biolink:BiologicalProcess oxidative stress-induced premature senescence A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0090403 GO:0090408 biolink:BiologicalProcess phloem nitrate loading The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink. go.json http://purl.obolibrary.org/obo/GO_0090408 GO:0090409 biolink:MolecularActivity malonyl-CoA synthetase activity Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate. EC:6.2.1.76|MetaCyc:RXN-12359|RHEA:32139 go.json http://purl.obolibrary.org/obo/GO_0090409 GO:0090406 biolink:CellularComponent pollen tube A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain. go.json http://purl.obolibrary.org/obo/GO_0090406 GO:0090407 biolink:BiologicalProcess organophosphate biosynthetic process The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. go.json http://purl.obolibrary.org/obo/GO_0090407 GO:0090400 biolink:BiologicalProcess stress-induced premature senescence A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. go.json SIPS http://purl.obolibrary.org/obo/GO_0090400 GO:0090401 biolink:BiologicalProcess obsolete viral-induced premature senescence OBSOLETE. A cellular senescence process associated with the dismantling of a cell as a response to viral infection. go.json True http://purl.obolibrary.org/obo/GO_0090401 GO:0090415 biolink:MolecularActivity 7-hydroxymethyl chlorophyll a reductase activity Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O. go.json http://purl.obolibrary.org/obo/GO_0090415 GO:0090416 biolink:MolecularActivity nicotinate transmembrane transporter activity Enables the transfer of nicotinate from one side of a membrane to the other. Reactome:R-HSA-8869603 go.json http://purl.obolibrary.org/obo/GO_0090416 GO:0090413 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process. go.json negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process True http://purl.obolibrary.org/obo/GO_0090413 GO:0090414 biolink:BiologicalProcess molybdate ion export from vacuole The directed movement of molybdate ions out of the vacuole. go.json http://purl.obolibrary.org/obo/GO_0090414 GO:0090419 biolink:BiologicalProcess obsolete negative regulation of transcription involved in G2/M transition of mitotic cell cycle OBSOLETE. Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle. go.json down-regulation of transcription from RNA polymerase II promoter during the G2/M transition of the mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0090419 GO:0090417 biolink:MolecularActivity N-methylnicotinate transmembrane transporter activity Enables the transfer of N-methylnicotinate from one side of a membrane to the other. go.json N-methylnicotinate transporter activity http://purl.obolibrary.org/obo/GO_0090417 GO:0090418 biolink:BiologicalProcess obsolete positive regulation of transcription involved in S-phase of mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the S phase of the mitotic cell cycle. go.json activation of S phase specific transcription in the mitotic cell cycle|activation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle|activation of transcription involved in S phase of mitotic cell cycle|positive regulation of S phase specific transcription in the mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle|positive regulation of transcription involved in S-phase of mitotic cell cycle|up-regulation of S phase specific transcription in the mitotic cell cycle|up-regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle|up-regulation of transcription involved in S phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0090418 GO:0090411 biolink:MolecularActivity brassinosteroid binding Binding to a brassinosteroid. go.json http://purl.obolibrary.org/obo/GO_0090411 GO:0090412 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process. go.json positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process True http://purl.obolibrary.org/obo/GO_0090412 GO:0090410 biolink:BiologicalProcess malonate catabolic process The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion. go.json http://purl.obolibrary.org/obo/GO_0090410 GO:1905000 biolink:BiologicalProcess regulation of membrane repolarization during atrial cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. go.json regulation of atrial repolarization|regulation of electrocardiogram QRS complex http://purl.obolibrary.org/obo/GO_1905000 GO:1905001 biolink:BiologicalProcess negative regulation of membrane repolarization during atrial cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. go.json down regulation of atrial repolarization|down regulation of electrocardiogram QRS complex|down regulation of membrane repolarization during atrial cardiac muscle cell action potential|down-regulation of atrial repolarization|down-regulation of electrocardiogram QRS complex|down-regulation of membrane repolarization during atrial cardiac muscle cell action potential|downregulation of atrial repolarization|downregulation of electrocardiogram QRS complex|downregulation of membrane repolarization during atrial cardiac muscle cell action potential|inhibition of atrial repolarization|inhibition of electrocardiogram QRS complex|inhibition of membrane repolarization during atrial cardiac muscle cell action potential|negative regulation of atrial repolarization|negative regulation of electrocardiogram QRS complex http://purl.obolibrary.org/obo/GO_1905001 GO:1905002 biolink:BiologicalProcess positive regulation of membrane repolarization during atrial cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. go.json activation of atrial repolarization|activation of electrocardiogram QRS complex|activation of membrane repolarization during atrial cardiac muscle cell action potential|positive regulation of atrial repolarization|positive regulation of electrocardiogram QRS complex|up regulation of atrial repolarization|up regulation of electrocardiogram QRS complex|up regulation of membrane repolarization during atrial cardiac muscle cell action potential|up-regulation of atrial repolarization|up-regulation of electrocardiogram QRS complex|up-regulation of membrane repolarization during atrial cardiac muscle cell action potential|upregulation of atrial repolarization|upregulation of electrocardiogram QRS complex|upregulation of membrane repolarization during atrial cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1905002 GO:1905003 biolink:BiologicalProcess picolinic acid metabolic process The chemical reactions and pathways involving picolinic acid. go.json picolinate metabolism|picolinic acid metabolism http://purl.obolibrary.org/obo/GO_1905003 GO:2000467 biolink:BiologicalProcess positive regulation of glycogen (starch) synthase activity Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity. go.json positive regulation of UDP-glucose-glycogen glucosyltransferase activity|positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity|positive regulation of UDP-glycogen synthase activity|positive regulation of UDPG-glycogen synthetase activity|positive regulation of UDPG-glycogen transglucosylase activity|positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity|positive regulation of glycogen (starch) synthetase activity|positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity http://purl.obolibrary.org/obo/GO_2000467 gocheck_do_not_annotate GO:2000468 biolink:BiologicalProcess regulation of peroxidase activity Any process that modulates the frequency, rate or extent of peroxidase activity. go.json regulation of donor:hydrogen-peroxide oxidoreductase activity|regulation of oxyperoxidase activity|regulation of peroxidase reaction http://purl.obolibrary.org/obo/GO_2000468 gocheck_do_not_annotate GO:2000469 biolink:BiologicalProcess negative regulation of peroxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity. go.json negative regulation of donor:hydrogen-peroxide oxidoreductase activity|negative regulation of oxyperoxidase activity|negative regulation of peroxidase reaction http://purl.obolibrary.org/obo/GO_2000469 gocheck_do_not_annotate GO:2000460 biolink:BiologicalProcess obsolete regulation of eukaryotic cell surface binding OBSOLETE. Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding. go.json regulation of eukaryotic cell surface binding True http://purl.obolibrary.org/obo/GO_2000460 GO:2000461 biolink:BiologicalProcess obsolete negative regulation of eukaryotic cell surface binding OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding. go.json negative regulation of eukaryotic cell surface binding True http://purl.obolibrary.org/obo/GO_2000461 GO:2000462 biolink:BiologicalProcess obsolete positive regulation of eukaryotic cell surface binding OBSOLETE. Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding. go.json positive regulation of eukaryotic cell surface binding True http://purl.obolibrary.org/obo/GO_2000462 GO:2000463 biolink:BiologicalProcess positive regulation of excitatory postsynaptic potential Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. go.json positive regulation of EPSP|positive regulation of excitatory post-synaptic membrane potential http://purl.obolibrary.org/obo/GO_2000463 GO:2000464 biolink:BiologicalProcess positive regulation of astrocyte chemotaxis Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000464 GO:2000465 biolink:BiologicalProcess regulation of glycogen (starch) synthase activity Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity. go.json regulation of UDP-glucose-glycogen glucosyltransferase activity|regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity|regulation of UDP-glycogen synthase activity|regulation of UDPG-glycogen synthetase activity|regulation of UDPG-glycogen transglucosylase activity|regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity|regulation of glycogen (starch) synthetase activity|regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity http://purl.obolibrary.org/obo/GO_2000465 gocheck_do_not_annotate GO:2000466 biolink:BiologicalProcess negative regulation of glycogen (starch) synthase activity Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity. go.json negative regulation of UDP-glucose-glycogen glucosyltransferase activity|negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity|negative regulation of UDP-glycogen synthase activity|negative regulation of UDPG-glycogen synthetase activity|negative regulation of UDPG-glycogen transglucosylase activity|negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity|negative regulation of glycogen (starch) synthetase activity|negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity http://purl.obolibrary.org/obo/GO_2000466 gocheck_do_not_annotate GO:2000478 biolink:BiologicalProcess positive regulation of metanephric podocyte development Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development. go.json positive regulation of metanephric glomerular visceral epithelial cell development http://purl.obolibrary.org/obo/GO_2000478 GO:2000479 biolink:BiologicalProcess regulation of cAMP-dependent protein kinase activity Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. go.json regulation of 3',5' cAMP-dependent protein kinase activity|regulation of 3',5'-cAMP-dependent protein kinase activity|regulation of AMPK|regulation of ATP:protein phosphotransferase (cAMP-dependent) activity|regulation of PKA|regulation of PKA C|regulation of STK22|regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity|regulation of cAMP-dependent protein kinase, intrinsic catalyst activity|regulation of cyclic AMP-dependent protein kinase activity|regulation of protein kinase A activity http://purl.obolibrary.org/obo/GO_2000479 gocheck_do_not_annotate GO:2000470 biolink:BiologicalProcess positive regulation of peroxidase activity Any process that activates or increases the frequency, rate or extent of peroxidase activity. go.json positive regulation of donor:hydrogen-peroxide oxidoreductase activity|positive regulation of oxyperoxidase activity|positive regulation of peroxidase reaction http://purl.obolibrary.org/obo/GO_2000470 gocheck_do_not_annotate GO:2000471 biolink:BiologicalProcess regulation of hematopoietic stem cell migration Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration. go.json regulation of hemopoietic stem cell migration http://purl.obolibrary.org/obo/GO_2000471 GO:2000472 biolink:BiologicalProcess negative regulation of hematopoietic stem cell migration Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration. go.json negative regulation of hemopoietic stem cell migration http://purl.obolibrary.org/obo/GO_2000472 GO:2000473 biolink:BiologicalProcess positive regulation of hematopoietic stem cell migration Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. go.json positive regulation of hemopoietic stem cell migration http://purl.obolibrary.org/obo/GO_2000473 GO:2000474 biolink:BiologicalProcess regulation of opioid receptor signaling pathway Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway. go.json regulation of opioid receptor signalling pathway http://purl.obolibrary.org/obo/GO_2000474 GO:2000475 biolink:BiologicalProcess negative regulation of opioid receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway. go.json negative regulation of opioid receptor signalling pathway http://purl.obolibrary.org/obo/GO_2000475 GO:2000476 biolink:BiologicalProcess positive regulation of opioid receptor signaling pathway Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway. go.json positive regulation of opioid receptor signalling pathway http://purl.obolibrary.org/obo/GO_2000476 GO:2000477 biolink:BiologicalProcess regulation of metanephric podocyte development Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development. go.json regulation of metanephric glomerular visceral epithelial cell development http://purl.obolibrary.org/obo/GO_2000477 OIO:hasRelatedSynonym biolink:OntologyClass has_related_synonym go.json http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym GO:2000489 biolink:BiologicalProcess regulation of hepatic stellate cell activation Any process that modulates the frequency, rate or extent of hepatic stellate cell activation. go.json http://purl.obolibrary.org/obo/GO_2000489 GO:2000481 biolink:BiologicalProcess positive regulation of cAMP-dependent protein kinase activity Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity. go.json positive regulation of 3',5' cAMP-dependent protein kinase activity|positive regulation of 3',5'-cAMP-dependent protein kinase activity|positive regulation of AMPK|positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity|positive regulation of PKA|positive regulation of PKA C|positive regulation of STK22|positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity|positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity|positive regulation of cyclic AMP-dependent protein kinase activity|positive regulation of protein kinase A activity http://purl.obolibrary.org/obo/GO_2000481 gocheck_do_not_annotate GO:2000482 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000482 GO:2000483 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000483 GO:2000484 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000484 GO:2000485 biolink:BiologicalProcess regulation of glutamine transport Any process that modulates the frequency, rate or extent of glutamine transport. go.json regulation of L-glutamine transport http://purl.obolibrary.org/obo/GO_2000485 GO:2000486 biolink:BiologicalProcess negative regulation of glutamine transport Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport. go.json negative regulation of L-glutamine transport http://purl.obolibrary.org/obo/GO_2000486 GO:2000487 biolink:BiologicalProcess positive regulation of glutamine transport Any process that activates or increases the frequency, rate or extent of glutamine transport. go.json positive regulation of L-glutamine transport http://purl.obolibrary.org/obo/GO_2000487 GO:2000488 biolink:BiologicalProcess positive regulation of brassinosteroid biosynthetic process Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process. go.json positive regulation of brassinosteroid anabolism|positive regulation of brassinosteroid biosynthesis|positive regulation of brassinosteroid formation|positive regulation of brassinosteroid synthesis http://purl.obolibrary.org/obo/GO_2000488 GO:2000480 biolink:BiologicalProcess negative regulation of cAMP-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. go.json negative regulation of 3',5' cAMP-dependent protein kinase activity|negative regulation of 3',5'-cAMP-dependent protein kinase activity|negative regulation of AMPK|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity|negative regulation of PKA|negative regulation of PKA C|negative regulation of STK22|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity|negative regulation of cyclic AMP-dependent protein kinase activity|negative regulation of protein kinase A activity http://purl.obolibrary.org/obo/GO_2000480 gocheck_do_not_annotate GO:2000492 biolink:BiologicalProcess regulation of interleukin-18-mediated signaling pathway Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway. go.json regulation of interleukin-18-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000492 GO:2000493 biolink:BiologicalProcess negative regulation of interleukin-18-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway. go.json negative regulation of interleukin-18-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000493 GO:2000494 biolink:BiologicalProcess positive regulation of interleukin-18-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway. go.json positive regulation of interleukin-18-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000494 GO:2000495 biolink:BiologicalProcess regulation of cell proliferation involved in compound eye morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000495 GO:2000496 biolink:BiologicalProcess negative regulation of cell proliferation involved in compound eye morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000496 GO:2000497 biolink:BiologicalProcess positive regulation of cell proliferation involved in compound eye morphogenesis Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000497 GO:2000498 biolink:BiologicalProcess obsolete regulation of induction of apoptosis in response to chemical stimulus OBSOLETE. Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus. go.json regulation of induction of apoptosis in response to chemical stimulus|regulation of induction of apoptosis in response to chemical substance True http://purl.obolibrary.org/obo/GO_2000498 GO:2000499 biolink:BiologicalProcess obsolete negative regulation of induction of apoptosis in response to chemical stimulus OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus. go.json negative regulation of induction of apoptosis in response to chemical stimulus|negative regulation of induction of apoptosis in response to chemical substance True http://purl.obolibrary.org/obo/GO_2000499 GO:2000490 biolink:BiologicalProcess negative regulation of hepatic stellate cell activation Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation. go.json http://purl.obolibrary.org/obo/GO_2000490 GO:2000491 biolink:BiologicalProcess positive regulation of hepatic stellate cell activation Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation. go.json http://purl.obolibrary.org/obo/GO_2000491 GO:2000423 biolink:BiologicalProcess negative regulation of eosinophil chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000423 GO:2000424 biolink:BiologicalProcess positive regulation of eosinophil chemotaxis Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000424 GO:2000425 biolink:BiologicalProcess regulation of apoptotic cell clearance Any process that modulates the frequency, rate or extent of apoptotic cell clearance. go.json regulation of apoptotic cell removal|regulation of efferocytosis|regulation of programmed cell clearance http://purl.obolibrary.org/obo/GO_2000425 GO:2000426 biolink:BiologicalProcess negative regulation of apoptotic cell clearance Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance. go.json negative regulation of apoptotic cell removal|negative regulation of efferocytosis|negative regulation of programmed cell clearance http://purl.obolibrary.org/obo/GO_2000426 GO:2000427 biolink:BiologicalProcess positive regulation of apoptotic cell clearance Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance. go.json positive regulation of apoptotic cell removal|positive regulation of efferocytosis|positive regulation of programmed cell clearance http://purl.obolibrary.org/obo/GO_2000427 GO:2000428 biolink:BiologicalProcess regulation of neutrophil aggregation Any process that modulates the frequency, rate or extent of neutrophil aggregation. go.json regulation of neutrocyte aggregation|regulation of neutrophil leucocyte aggregation|regulation of neutrophilic leukocyte aggregation http://purl.obolibrary.org/obo/GO_2000428 GO:2000429 biolink:BiologicalProcess negative regulation of neutrophil aggregation Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation. go.json negative regulation of neutrocyte aggregation|negative regulation of neutrophil leucocyte aggregation|negative regulation of neutrophilic leukocyte aggregation http://purl.obolibrary.org/obo/GO_2000429 GO:2000420 biolink:BiologicalProcess negative regulation of eosinophil extravasation Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation. go.json http://purl.obolibrary.org/obo/GO_2000420 GO:2000421 biolink:BiologicalProcess positive regulation of eosinophil extravasation Any process that activates or increases the frequency, rate or extent of eosinophil extravasation. go.json http://purl.obolibrary.org/obo/GO_2000421 GO:2000422 biolink:BiologicalProcess regulation of eosinophil chemotaxis Any process that modulates the frequency, rate or extent of eosinophil chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000422 GO:2000434 biolink:BiologicalProcess regulation of protein neddylation Any process that modulates the frequency, rate or extent of protein neddylation. go.json regulation of RUB1-protein conjugation http://purl.obolibrary.org/obo/GO_2000434 GO:2000435 biolink:BiologicalProcess negative regulation of protein neddylation Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation. go.json negative regulation of RUB1-protein conjugation http://purl.obolibrary.org/obo/GO_2000435 GO:2000436 biolink:BiologicalProcess positive regulation of protein neddylation Any process that activates or increases the frequency, rate or extent of protein neddylation. go.json positive regulation of RUB1-protein conjugation http://purl.obolibrary.org/obo/GO_2000436 GO:2000437 biolink:BiologicalProcess regulation of monocyte extravasation Any process that modulates the frequency, rate or extent of monocyte extravasation. go.json http://purl.obolibrary.org/obo/GO_2000437 GO:2000438 biolink:BiologicalProcess negative regulation of monocyte extravasation Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation. go.json http://purl.obolibrary.org/obo/GO_2000438 GO:2000439 biolink:BiologicalProcess positive regulation of monocyte extravasation Any process that activates or increases the frequency, rate or extent of monocyte extravasation. go.json http://purl.obolibrary.org/obo/GO_2000439 GO:2000430 biolink:BiologicalProcess positive regulation of neutrophil aggregation Any process that activates or increases the frequency, rate or extent of neutrophil aggregation. go.json positive regulation of neutrocyte aggregation|positive regulation of neutrophil leucocyte aggregation|positive regulation of neutrophilic leukocyte aggregation http://purl.obolibrary.org/obo/GO_2000430 GO:2000431 biolink:BiologicalProcess regulation of cytokinesis, actomyosin contractile ring assembly Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. go.json regulation of contractile ring assembly http://purl.obolibrary.org/obo/GO_2000431 GO:2000432 biolink:BiologicalProcess negative regulation of cytokinesis, actomyosin contractile ring assembly Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. go.json negative regulation of contractile ring assembly http://purl.obolibrary.org/obo/GO_2000432 GO:2000433 biolink:BiologicalProcess positive regulation of cytokinesis, actomyosin contractile ring assembly Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. go.json positive regulation of contractile ring assembly http://purl.obolibrary.org/obo/GO_2000433 GO:2000445 biolink:BiologicalProcess positive regulation of toll-like receptor 21 signaling pathway Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway. go.json positive regulation of TLR21 signaling pathway|positive regulation of toll-like receptor 21 signalling pathway http://purl.obolibrary.org/obo/GO_2000445 GO:2000446 biolink:BiologicalProcess regulation of macrophage migration inhibitory factor signaling pathway Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway. go.json regulation of MIF signaling pathway|regulation of macrophage migration inhibitory factor signalling pathway http://purl.obolibrary.org/obo/GO_2000446 GO:2000447 biolink:BiologicalProcess negative regulation of macrophage migration inhibitory factor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway. go.json negative regulation of MIF signaling pathway|negative regulation of macrophage migration inhibitory factor signalling pathway http://purl.obolibrary.org/obo/GO_2000447 GO:2000448 biolink:BiologicalProcess positive regulation of macrophage migration inhibitory factor signaling pathway Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway. go.json positive regulation of MIF signaling pathway|positive regulation of macrophage migration inhibitory factor signalling pathway http://purl.obolibrary.org/obo/GO_2000448 GO:2000449 biolink:BiologicalProcess regulation of CD8-positive, alpha-beta T cell extravasation Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000449 GO:2000440 biolink:BiologicalProcess regulation of toll-like receptor 15 signaling pathway Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway. go.json regulation of TLR15 signaling pathway|regulation of toll-like receptor 15 signalling pathway http://purl.obolibrary.org/obo/GO_2000440 GO:2000441 biolink:BiologicalProcess negative regulation of toll-like receptor 15 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway. go.json negative regulation of TLR15 signaling pathway|negative regulation of toll-like receptor 15 signalling pathway http://purl.obolibrary.org/obo/GO_2000441 GO:2000442 biolink:BiologicalProcess positive regulation of toll-like receptor 15 signaling pathway Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway. go.json positive regulation of TLR15 signaling pathway|positive regulation of toll-like receptor 15 signalling pathway http://purl.obolibrary.org/obo/GO_2000442 GO:2000443 biolink:BiologicalProcess regulation of toll-like receptor 21 signaling pathway Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway. go.json regulation of TLR21 signaling pathway|regulation of toll-like receptor 21 signalling pathway http://purl.obolibrary.org/obo/GO_2000443 GO:2000444 biolink:BiologicalProcess negative regulation of toll-like receptor 21 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway. go.json negative regulation of TLR21 signaling pathway|negative regulation of toll-like receptor 21 signalling pathway http://purl.obolibrary.org/obo/GO_2000444 GO:2000456 biolink:BiologicalProcess negative regulation of T-helper 17 cell extravasation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000456 GO:2000457 biolink:BiologicalProcess positive regulation of T-helper 17 cell extravasation Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000457 GO:2000458 biolink:BiologicalProcess regulation of astrocyte chemotaxis Any process that modulates the frequency, rate or extent of astrocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000458 GO:2000459 biolink:BiologicalProcess negative regulation of astrocyte chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2000459 GO:2000450 biolink:BiologicalProcess negative regulation of CD8-positive, alpha-beta T cell extravasation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000450 GO:2000451 biolink:BiologicalProcess positive regulation of CD8-positive, alpha-beta T cell extravasation Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000451 GO:2000452 biolink:BiologicalProcess regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000452 GO:2000453 biolink:BiologicalProcess negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000453 GO:2000454 biolink:BiologicalProcess positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000454 GO:2000455 biolink:BiologicalProcess regulation of T-helper 17 cell extravasation Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation. go.json http://purl.obolibrary.org/obo/GO_2000455 GO:0016466 biolink:MolecularActivity obsolete hydrogen-translocating A-type ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae. go.json hydrogen-translocating A-type ATPase activity|proton-translocating A-type ATPase activity True http://purl.obolibrary.org/obo/GO_0016466 GO:0016467 biolink:MolecularActivity obsolete hydrogen-translocating F-type ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria. go.json ATP synthase|F1-ATPase activity|hydrogen-translocating F-type ATPase activity|proton-translocating F-type ATPase activity True http://purl.obolibrary.org/obo/GO_0016467 GO:0016468 biolink:MolecularActivity obsolete sodium-translocating F-type ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria. go.json ATP synthase|sodium-translocating F-type ATPase activity True http://purl.obolibrary.org/obo/GO_0016468 GO:0016469 biolink:CellularComponent proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. go.json hydrogen-transporting two-sector ATPase complex|vacuolar hydrogen-transporting ATPase http://purl.obolibrary.org/obo/GO_0016469 goslim_metagenomics|goslim_pir GO:0016462 biolink:MolecularActivity pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. Reactome:R-HSA-6810472 go.json http://purl.obolibrary.org/obo/GO_0016462 GO:0016463 biolink:MolecularActivity P-type zinc transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out). EC:7.2.2.12|MetaCyc:RXN0-5205|RHEA:20621 go.json ATP phosphohydrolase (Zn2+-exporting)|P(1B)-type ATPase activity|P1B-type ATPase activity|Zn(2+)-exporting ATPase activity|Zn2+-exporting ATPase activity|zinc exporting ATPase activity|zinc transmembrane transporter activity, phosphorylative mechanism|zinc-exporting ATPase activity|zinc-translocating P-type ATPase activity http://purl.obolibrary.org/obo/GO_0016463 GO:0016464 biolink:MolecularActivity chloroplast protein-transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma. EC:7.4.2.4|MetaCyc:3.6.3.52-RXN go.json AAA chloroplast protein-transporting ATPase|ATPase-coupled chloroplast protein transporter activity http://purl.obolibrary.org/obo/GO_0016464 GO:0016465 biolink:CellularComponent chaperonin ATPase complex Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. go.json http://purl.obolibrary.org/obo/GO_0016465 GO:0016460 biolink:CellularComponent myosin II complex A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. go.json conventional myosin http://purl.obolibrary.org/obo/GO_0016460 GO:0016461 biolink:CellularComponent unconventional myosin complex A portmanteau term for myosins other than myosin II. go.json non-muscle myosin http://purl.obolibrary.org/obo/GO_0016461 GO:0016477 biolink:BiologicalProcess cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Wikipedia:Cell_migration go.json http://purl.obolibrary.org/obo/GO_0016477 GO:0016478 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016478 GO:0016479 biolink:BiologicalProcess negative regulation of transcription by RNA polymerase I Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I. go.json down regulation of transcription from RNA polymerase I promoter|down-regulation of transcription from RNA polymerase I promoter|downregulation of transcription from RNA polymerase I promoter|inhibition of transcription from RNA polymerase I promoter|negative regulation of transcription from Pol I promoter|negative regulation of transcription from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_0016479 GO:0016473 biolink:CellularComponent sodium ion-transporting F-type ATPase complex A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism. go.json sodium-translocating F-type ATPase complex http://purl.obolibrary.org/obo/GO_0016473 GO:0016474 biolink:CellularComponent sodium ion-transporting V-type ATPase complex A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. go.json sodium-translocating V-type ATPase complex http://purl.obolibrary.org/obo/GO_0016474 GO:0016475 biolink:BiologicalProcess detection of nuclear:cytoplasmic ratio The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell. go.json interpretation of nuclear:cytoplasmic ratio|sensing of nuclear:cytoplasmic ratio http://purl.obolibrary.org/obo/GO_0016475 GO:0016476 biolink:BiologicalProcess regulation of embryonic cell shape Any process that modulates the surface configuration of an embryonic cell. go.json shape changes of embryonic cells http://purl.obolibrary.org/obo/GO_0016476 GO:0016470 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016470 GO:0016471 biolink:CellularComponent vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. go.json vacuolar hydrogen-translocating V-type ATPase complex http://purl.obolibrary.org/obo/GO_0016471 GO:0016472 biolink:CellularComponent sodium ion-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis. go.json sodium-transporting two-sector ATPase complex http://purl.obolibrary.org/obo/GO_0016472 goslim_pir GO:0090381 biolink:BiologicalProcess regulation of heart induction Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. go.json http://purl.obolibrary.org/obo/GO_0090381 GO:0090382 biolink:BiologicalProcess phagosome maturation A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. go.json http://purl.obolibrary.org/obo/GO_0090382 GO:0090380 biolink:BiologicalProcess seed trichome maturation A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0090380 GO:0016448 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016448 GO:0016449 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016449 GO:0016444 biolink:BiologicalProcess somatic cell DNA recombination Recombination occurring within or between DNA molecules in somatic cells. go.json http://purl.obolibrary.org/obo/GO_0016444 GO:0016445 biolink:BiologicalProcess somatic diversification of immunoglobulins The somatic process that results in the generation of sequence diversity of immunoglobulins. go.json somatic diversification of antibodies http://purl.obolibrary.org/obo/GO_0016445 GO:0016446 biolink:BiologicalProcess somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. go.json somatic hypermutation of antibody genes http://purl.obolibrary.org/obo/GO_0016446 GO:0016447 biolink:BiologicalProcess somatic recombination of immunoglobulin gene segments The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. go.json somatic recombination of antibody gene segments http://purl.obolibrary.org/obo/GO_0016447 GO:0090385 biolink:BiologicalProcess phagosome-lysosome fusion The creation of a phagolysosome from a phagosome and a lysosome. go.json http://purl.obolibrary.org/obo/GO_0090385 GO:0016440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016440 GO:0016441 biolink:BiologicalProcess post-transcriptional gene silencing The inactivation of gene expression that occurs after transcription. Wikipedia:Post_transcriptional_gene_silencing go.json PTGS|posttranscriptional gene silencing http://purl.obolibrary.org/obo/GO_0016441 GO:0090386 biolink:BiologicalProcess phagosome maturation involved in apoptotic cell clearance A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. go.json http://purl.obolibrary.org/obo/GO_0090386 GO:0090383 biolink:BiologicalProcess phagosome acidification Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. go.json phagosomal acidification http://purl.obolibrary.org/obo/GO_0090383 GO:0016442 biolink:CellularComponent RISC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. Wikipedia:RNA-induced_silencing_complex go.json RNA-induced silencing complex|miRNP complex|micro-ribonucleoprotein complex http://purl.obolibrary.org/obo/GO_0016442 GO:0090384 biolink:BiologicalProcess phagosome-lysosome docking The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere. go.json lysosome recruitment to phagosome http://purl.obolibrary.org/obo/GO_0090384 GO:0016443 biolink:MolecularActivity bidentate ribonuclease III activity Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference. EC:3.1.26.- go.json bidentate RNase III activity http://purl.obolibrary.org/obo/GO_0016443 GO:0090389 biolink:BiologicalProcess phagosome-lysosome fusion involved in apoptotic cell clearance The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance. go.json http://purl.obolibrary.org/obo/GO_0090389 GO:0090387 biolink:BiologicalProcess phagolysosome assembly involved in apoptotic cell clearance The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance. go.json http://purl.obolibrary.org/obo/GO_0090387 GO:0090388 biolink:BiologicalProcess phagosome-lysosome docking involved in apoptotic cell clearance The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere. go.json http://purl.obolibrary.org/obo/GO_0090388 GO:0090392 biolink:BiologicalProcess sepal giant cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C. go.json http://purl.obolibrary.org/obo/GO_0090392 GO:0090393 biolink:BiologicalProcess sepal giant cell development The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json sepal giant cell formation http://purl.obolibrary.org/obo/GO_0090393 GO:0090390 biolink:BiologicalProcess phagosome acidification involved in apoptotic cell clearance Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance. go.json http://purl.obolibrary.org/obo/GO_0090390 GO:0090391 biolink:BiologicalProcess granum assembly A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts. go.json grana formation http://purl.obolibrary.org/obo/GO_0090391 GO:0016459 biolink:CellularComponent myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. go.json http://purl.obolibrary.org/obo/GO_0016459 GO:0016455 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016455 GO:0016456 biolink:CellularComponent X chromosome located dosage compensation complex, transcription activating An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster. go.json dosage compensation complex http://purl.obolibrary.org/obo/GO_0016456 GO:0016457 biolink:BiologicalProcess obsolete dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome OBSOLETE. The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster. go.json dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome True http://purl.obolibrary.org/obo/GO_0016457 GO:0016458 biolink:BiologicalProcess obsolete gene silencing OBSOLETE. Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. Wikipedia:Gene_silencing go.json True http://purl.obolibrary.org/obo/GO_0016458 GO:0090396 biolink:CellularComponent leaf papilla A plant cell papilla that is part of a leaf papilla cell. go.json http://purl.obolibrary.org/obo/GO_0090396 GO:0016451 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016451 GO:0016452 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016452 GO:0090397 biolink:CellularComponent stigma papilla A plant cell papilla that is part of a stigma papilla cell. go.json http://purl.obolibrary.org/obo/GO_0090397 GO:0090394 biolink:BiologicalProcess negative regulation of excitatory postsynaptic potential Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. go.json negative regulation of EPSP|negative regulation of excitatory post-synaptic membrane potential|reduction of excitatory postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_0090394 GO:0016453 biolink:MolecularActivity C-acetyltransferase activity Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016453 GO:0090395 biolink:CellularComponent plant cell papilla A cell projection that is a short, rounded projection from a plant epidermal cell. go.json http://purl.obolibrary.org/obo/GO_0090395 GO:0016454 biolink:MolecularActivity C-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016454 GO:0090398 biolink:BiologicalProcess cellular senescence A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. go.json http://purl.obolibrary.org/obo/GO_0090398 GO:0016450 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016450 GO:0090399 biolink:BiologicalProcess replicative senescence A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. go.json http://purl.obolibrary.org/obo/GO_0090399 GO:0016426 biolink:MolecularActivity tRNA (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine. go.json tRNA (adenine-C2-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016426 GO:0016427 biolink:MolecularActivity tRNA (cytidine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. go.json tRNA (cytosine) methyltransferase activity http://purl.obolibrary.org/obo/GO_0016427 GO:0016428 biolink:MolecularActivity tRNA (cytidine-5-)-methyltransferase activity Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49). EC:2.1.1.202|RHEA:61468|Reactome:R-HSA-6782388|Reactome:R-HSA-6782419|Reactome:R-HSA-6785409|Reactome:R-HSA-6785438|Reactome:R-HSA-8932765 go.json S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity|tRNA (cytosine-5-)-methyltransferase activity|transfer RNA cytosine 5-methyltransferase activity|transfer ribonucleate cytosine 5-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016428 GO:0016429 biolink:MolecularActivity tRNA (adenine-N1)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. Reactome:R-HSA-6783492|Reactome:R-HSA-6787525|Reactome:R-HSA-6787594 go.json 1-methyladenine transfer RNA methyltransferase activity|S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity|adenine-1-methylase activity|tRNA (adenine-N1-)-methyltransferase activity|transfer RNA (adenine-1) methyltransferase activity|transfer ribonucleate adenine 1-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016429 GO:0016422 biolink:MolecularActivity mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. EC:2.1.1.62|MetaCyc:2.1.1.62-RXN|RHEA:22744 go.json S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity|S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016422 GO:0016423 biolink:MolecularActivity tRNA (guanine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. go.json tRNA (guanosine) methyltransferase activity http://purl.obolibrary.org/obo/GO_0016423 GO:0016424 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016424 GO:0016425 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016425 GO:0016420 biolink:MolecularActivity malonyltransferase activity Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016420 GO:0016421 biolink:MolecularActivity CoA carboxylase activity Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. go.json http://purl.obolibrary.org/obo/GO_0016421 GO:0016437 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016437 GO:0016438 biolink:MolecularActivity tRNA-queuosine beta-mannosyltransferase activity Catalysis of the reaction: GDP-alpha-D-mannose + queuosine34 in tRNA(Asp) = GDP + H+ + O-4''-alpha-D-mannosylqueuosine34 in tRNA(Asp). EC:2.4.1.110|MetaCyc:2.4.1.110-RXN|RHEA:12885 go.json GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0016438 GO:0016439 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016439 GO:0016433 biolink:MolecularActivity rRNA (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. go.json http://purl.obolibrary.org/obo/GO_0016433 GO:0016434 biolink:MolecularActivity rRNA (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. go.json http://purl.obolibrary.org/obo/GO_0016434 GO:0016435 biolink:MolecularActivity rRNA (guanine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine. go.json http://purl.obolibrary.org/obo/GO_0016435 GO:0016436 biolink:MolecularActivity rRNA (uridine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine. go.json http://purl.obolibrary.org/obo/GO_0016436 GO:0016430 biolink:MolecularActivity tRNA (adenine-N6)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. EC:2.1.1.55|MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN|RHEA:16785 go.json S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity|tRNA (adenine-N6-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016430 GO:0016431 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016431 GO:0016432 biolink:MolecularActivity tRNA-uridine aminocarboxypropyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine. EC:2.5.1.25|MetaCyc:2.5.1.25-RXN|RHEA:12300 go.json S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity http://purl.obolibrary.org/obo/GO_0016432 GO:0016408 biolink:MolecularActivity C-acyltransferase activity Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016408 GO:0016409 biolink:MolecularActivity palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. Reactome:R-HSA-203567|Reactome:R-HSA-5686304 go.json http://purl.obolibrary.org/obo/GO_0016409 GO:0016404 biolink:MolecularActivity 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. EC:1.1.1.141|MetaCyc:1.1.1.141-RXN|RHEA:11876|Reactome:R-HSA-2161662|Reactome:R-HSA-2161779|Reactome:R-HSA-9023968|Reactome:R-HSA-9024766 go.json (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity|11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity|15-OH-PGDH|15-hydroxyprostaglandin dehydrogenase activity|15-hydroxyprostanoic dehydrogenase activity|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)|NAD-specific 15-hydroxyprostaglandin dehydrogenase activity|prostaglandin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0016404 GO:0016405 biolink:MolecularActivity CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. Reactome:R-HSA-159443|Reactome:R-HSA-159567|Reactome:R-HSA-177157|Reactome:R-HSA-6798345|Reactome:R-HSA-9749971 go.json http://purl.obolibrary.org/obo/GO_0016405 GO:0016406 biolink:MolecularActivity carnitine O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. go.json http://purl.obolibrary.org/obo/GO_0016406 GO:0016407 biolink:MolecularActivity acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule. Reactome:R-HSA-5628871|Reactome:R-HSA-5660660|Reactome:R-HSA-5682044|Reactome:R-HSA-6792712|Reactome:R-HSA-6805638|Reactome:R-HSA-73736 go.json acetylase activity http://purl.obolibrary.org/obo/GO_0016407 GO:0016400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016400 GO:0016401 biolink:MolecularActivity palmitoyl-CoA oxidase activity Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. go.json http://purl.obolibrary.org/obo/GO_0016401 GO:0016402 biolink:MolecularActivity pristanoyl-CoA oxidase activity Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. RHEA:40459|Reactome:R-HSA-389889|Reactome:R-HSA-389891 go.json http://purl.obolibrary.org/obo/GO_0016402 GO:0016403 biolink:MolecularActivity dimethylargininase activity Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. EC:3.5.3.18|MetaCyc:DIMETHYLARGININASE-RXN|RHEA:17305|Reactome:R-HSA-5693373 go.json N(G),N(G)-dimethylarginine dimethylaminohydrolase activity|NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity|NG,NG-dimethylarginine dimethylaminohydrolase activity|dimethylarginine dimethylaminohydrolase activity http://purl.obolibrary.org/obo/GO_0016403 GO:0016419 biolink:MolecularActivity S-malonyltransferase activity Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule. EC:2.3.1.39 go.json http://purl.obolibrary.org/obo/GO_0016419 GO:0016415 biolink:MolecularActivity octanoyltransferase activity Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. EC:2.3.1.181 go.json http://purl.obolibrary.org/obo/GO_0016415 GO:0016416 biolink:MolecularActivity O-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. Reactome:R-HSA-2404137|Reactome:R-HSA-2453855|Reactome:R-HSA-2466710 go.json http://purl.obolibrary.org/obo/GO_0016416 GO:0016417 biolink:MolecularActivity S-acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016417 GO:0016418 biolink:MolecularActivity S-acetyltransferase activity Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016418 GO:0016411 biolink:MolecularActivity acylglycerol O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. Reactome:R-HSA-1482647|Reactome:R-HSA-1482654 go.json http://purl.obolibrary.org/obo/GO_0016411 GO:0016412 biolink:MolecularActivity serine O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. EC:2.3.1.30 go.json http://purl.obolibrary.org/obo/GO_0016412 GO:0016413 biolink:MolecularActivity O-acetyltransferase activity Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016413 GO:0016414 biolink:MolecularActivity O-octanoyltransferase activity Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016414 GO:0016410 biolink:MolecularActivity N-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. Reactome:R-HSA-177160 go.json http://purl.obolibrary.org/obo/GO_0016410 GO:1905370 biolink:CellularComponent serine-type endopeptidase complex A protein complex which is capable of serine-type endopeptidase activity. go.json http://purl.obolibrary.org/obo/GO_1905370 GO:1905371 biolink:BiologicalProcess ceramide phosphoethanolamine metabolic process The chemical reactions and pathways involving ceramide phosphoethanolamine. go.json ceramide phosphoethanolamine metabolism http://purl.obolibrary.org/obo/GO_1905371 GO:1905372 biolink:BiologicalProcess ceramide phosphoethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of ceramide phosphoethanolamine. go.json ceramide phosphoethanolamine breakdown|ceramide phosphoethanolamine catabolism|ceramide phosphoethanolamine degradation http://purl.obolibrary.org/obo/GO_1905372 GO:1905373 biolink:BiologicalProcess ceramide phosphoethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of ceramide phosphoethanolamine. go.json ceramide phosphoethanolamine anabolism|ceramide phosphoethanolamine biosynthesis|ceramide phosphoethanolamine formation|ceramide phosphoethanolamine synthesis http://purl.obolibrary.org/obo/GO_1905373 GO:1905374 biolink:BiologicalProcess response to homocysteine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus. go.json response to 2-amino-4-mercaptobutyric acid|response to 2-amino-4-sulfanylbutanoic acid|response to Hcy http://purl.obolibrary.org/obo/GO_1905374 GO:1905375 biolink:BiologicalProcess cellular response to homocysteine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus. go.json cellular response to 2-amino-4-mercaptobutyric acid|cellular response to 2-amino-4-sulfanylbutanoic acid|cellular response to Hcy http://purl.obolibrary.org/obo/GO_1905375 GO:1905376 biolink:BiologicalProcess negative regulation of cytochrome-c oxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity. go.json down regulation of NADH cytochrome c oxidase|down regulation of aa3-type cytochrome c oxidase|down regulation of ba3-type cytochrome c oxidase|down regulation of caa3-type cytochrome c oxidase|down regulation of cbb3-type cytochrome c oxidase|down regulation of complex IV (mitochondrial electron transport) activity|down regulation of cytochrome a3 activity|down regulation of cytochrome aa3 activity|down regulation of cytochrome c oxidase activity|down regulation of cytochrome oxidase activity|down regulation of cytochrome-c oxidase activity|down regulation of ferrocytochrome c oxidase|down regulation of ferrocytochrome-c:oxygen oxidoreductase|down regulation of indophenol oxidase|down regulation of indophenolase|down regulation of warburg's respiratory enzyme activity|down-regulation of NADH cytochrome c oxidase|down-regulation of aa3-type cytochrome c oxidase|down-regulation of ba3-type cytochrome c oxidase|down-regulation of caa3-type cytochrome c oxidase|down-regulation of cbb3-type cytochrome c oxidase|down-regulation of complex IV (mitochondrial electron transport) activity|down-regulation of cytochrome a3 activity|down-regulation of cytochrome aa3 activity|down-regulation of cytochrome c oxidase activity|down-regulation of cytochrome oxidase activity|down-regulation of cytochrome-c oxidase activity|down-regulation of ferrocytochrome c oxidase|down-regulation of ferrocytochrome-c:oxygen oxidoreductase|down-regulation of indophenol oxidase|down-regulation of indophenolase|down-regulation of warburg's respiratory enzyme activity|downregulation of NADH cytochrome c oxidase|downregulation of aa3-type cytochrome c oxidase|downregulation of ba3-type cytochrome c oxidase|downregulation of caa3-type cytochrome c oxidase|downregulation of cbb3-type cytochrome c oxidase|downregulation of complex IV (mitochondrial electron transport) activity|downregulation of cytochrome a3 activity|downregulation of cytochrome aa3 activity|downregulation of cytochrome c oxidase activity|downregulation of cytochrome oxidase activity|downregulation of cytochrome-c oxidase activity|downregulation of ferrocytochrome c oxidase|downregulation of ferrocytochrome-c:oxygen oxidoreductase|downregulation of indophenol oxidase|downregulation of indophenolase|downregulation of warburg's respiratory enzyme activity|inhibition of NADH cytochrome c oxidase|inhibition of aa3-type cytochrome c oxidase|inhibition of ba3-type cytochrome c oxidase|inhibition of caa3-type cytochrome c oxidase|inhibition of cbb3-type cytochrome c oxidase|inhibition of complex IV (mitochondrial electron transport) activity|inhibition of cytochrome a3 activity|inhibition of cytochrome aa3 activity|inhibition of cytochrome c oxidase activity|inhibition of cytochrome oxidase activity|inhibition of cytochrome-c oxidase activity|inhibition of ferrocytochrome c oxidase|inhibition of ferrocytochrome-c:oxygen oxidoreductase|inhibition of indophenol oxidase|inhibition of indophenolase|inhibition of warburg's respiratory enzyme activity|negative regulation of NADH cytochrome c oxidase|negative regulation of aa3-type cytochrome c oxidase|negative regulation of ba3-type cytochrome c oxidase|negative regulation of caa3-type cytochrome c oxidase|negative regulation of cbb3-type cytochrome c oxidase|negative regulation of complex IV (mitochondrial electron transport) activity|negative regulation of cytochrome a3 activity|negative regulation of cytochrome aa3 activity|negative regulation of cytochrome c oxidase activity|negative regulation of cytochrome oxidase activity|negative regulation of ferrocytochrome c oxidase|negative regulation of ferrocytochrome-c:oxygen oxidoreductase|negative regulation of indophenol oxidase|negative regulation of indophenolase|negative regulation of warburg's respiratory enzyme activity http://purl.obolibrary.org/obo/GO_1905376 gocheck_do_not_annotate GO:1905377 biolink:BiologicalProcess response to D-galactose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus. go.json response to D-Gal|response to D-galacto-hexose http://purl.obolibrary.org/obo/GO_1905377 GO:1905367 biolink:BiologicalProcess positive regulation of intralumenal vesicle formation Any process that activates or increases the frequency, rate or extent of intralumenal vesicle formation. go.json activation of endosome membrane budding|activation of intralumenal vesicle formation|positive regulation of endosome membrane budding|up regulation of endosome membrane budding|up regulation of intralumenal vesicle formation|up-regulation of endosome membrane budding|up-regulation of intralumenal vesicle formation|upregulation of endosome membrane budding|upregulation of intralumenal vesicle formation http://purl.obolibrary.org/obo/GO_1905367 GO:0090569 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090569 GO:1905368 biolink:CellularComponent peptidase complex A protein complex which is capable of peptidase activity. go.json protease complex|tryptase complex http://purl.obolibrary.org/obo/GO_1905368 GO:1905369 biolink:CellularComponent endopeptidase complex A protein complex which is capable of endopeptidase activity. go.json http://purl.obolibrary.org/obo/GO_1905369 GO:0090567 biolink:BiologicalProcess reproductive shoot system development The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0090567 GO:0090568 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090568 GO:0090561 biolink:BiologicalProcess nuclear migration during mitotic telophase The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0090561 GO:0090562 biolink:MolecularActivity protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090562 GO:0090560 biolink:MolecularActivity 2-(3-amino-3-carboxypropyl)histidine synthase activity Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]. EC:2.5.1.108|MetaCyc:RXN-11371|RHEA:36783|Reactome:R-HSA-5358494 go.json http://purl.obolibrary.org/obo/GO_0090560 GO:0090565 biolink:MolecularActivity protein-phosphocysteine-mannitol phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json http://purl.obolibrary.org/obo/GO_0090565 GO:0090566 biolink:MolecularActivity protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090566 GO:0090563 biolink:MolecularActivity protein-phosphocysteine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json http://purl.obolibrary.org/obo/GO_0090563 GO:0090564 biolink:MolecularActivity protein-phosphocysteine-glucose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json http://purl.obolibrary.org/obo/GO_0090564 GO:1905380 biolink:BiologicalProcess regulation of snRNA transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. go.json regulation of snRNA transcription from Pol II promoter|regulation of snRNA transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_1905380 GO:1905381 biolink:BiologicalProcess negative regulation of snRNA transcription by RNA polymerase II Any process that stops, prevents or reduces the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. go.json down regulation of snRNA transcription from Pol II promoter|down regulation of snRNA transcription from RNA polymerase II promoter|down-regulation of snRNA transcription from Pol II promoter|down-regulation of snRNA transcription from RNA polymerase II promoter|downregulation of snRNA transcription from Pol II promoter|downregulation of snRNA transcription from RNA polymerase II promoter|inhibition of snRNA transcription from Pol II promoter|inhibition of snRNA transcription from RNA polymerase II promoter|negative regulation of snRNA transcription from Pol II promoter|negative regulation of snRNA transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_1905381 GO:1905382 biolink:BiologicalProcess positive regulation of snRNA transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. go.json activation of snRNA transcription from Pol II promoter|activation of snRNA transcription from RNA polymerase II promoter|positive regulation of snRNA transcription from Pol II promoter|positive regulation of snRNA transcription from RNA polymerase II promoter|up regulation of snRNA transcription from Pol II promoter|up regulation of snRNA transcription from RNA polymerase II promoter|up-regulation of snRNA transcription from Pol II promoter|up-regulation of snRNA transcription from RNA polymerase II promoter|upregulation of snRNA transcription from Pol II promoter|upregulation of snRNA transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_1905382 GO:1905383 biolink:BiologicalProcess protein localization to presynapse A process in which a protein is transported to, or maintained in, a location within a presynapse. go.json protein localisation in presynapse|protein localisation to presynapse|protein localization in presynapse|recruitment of presynaptic proteins http://purl.obolibrary.org/obo/GO_1905383 GO:1905384 biolink:BiologicalProcess regulation of protein localization to presynapse Any process that modulates the frequency, rate or extent of protein localization to presynapse. go.json regulation of protein localisation in presynapse|regulation of protein localisation to presynapse|regulation of protein localization in presynapse|regulation of recruitment of presynaptic proteins http://purl.obolibrary.org/obo/GO_1905384 GO:1905385 biolink:BiologicalProcess negative regulation of protein localization to presynapse Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. go.json down regulation of protein localisation in presynapse|down regulation of protein localisation to presynapse|down regulation of protein localization in presynapse|down regulation of protein localization to presynapse|down regulation of recruitment of presynaptic proteins|down-regulation of protein localisation in presynapse|down-regulation of protein localisation to presynapse|down-regulation of protein localization in presynapse|down-regulation of protein localization to presynapse|down-regulation of recruitment of presynaptic proteins|downregulation of protein localisation in presynapse|downregulation of protein localisation to presynapse|downregulation of protein localization in presynapse|downregulation of protein localization to presynapse|downregulation of recruitment of presynaptic proteins|inhibition of protein localisation in presynapse|inhibition of protein localisation to presynapse|inhibition of protein localization in presynapse|inhibition of protein localization to presynapse|inhibition of recruitment of presynaptic proteins|negative regulation of protein localisation in presynapse|negative regulation of protein localisation to presynapse|negative regulation of protein localization in presynapse|negative regulation of recruitment of presynaptic proteins http://purl.obolibrary.org/obo/GO_1905385 GO:1905386 biolink:BiologicalProcess positive regulation of protein localization to presynapse Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. go.json activation of protein localisation in presynapse|activation of protein localisation to presynapse|activation of protein localization in presynapse|activation of protein localization to presynapse|activation of recruitment of presynaptic proteins|positive regulation of protein localisation in presynapse|positive regulation of protein localisation to presynapse|positive regulation of protein localization in presynapse|positive regulation of recruitment of presynaptic proteins|up regulation of protein localisation in presynapse|up regulation of protein localisation to presynapse|up regulation of protein localization in presynapse|up regulation of protein localization to presynapse|up regulation of recruitment of presynaptic proteins|up-regulation of protein localisation in presynapse|up-regulation of protein localisation to presynapse|up-regulation of protein localization in presynapse|up-regulation of protein localization to presynapse|up-regulation of recruitment of presynaptic proteins|upregulation of protein localisation in presynapse|upregulation of protein localisation to presynapse|upregulation of protein localization in presynapse|upregulation of protein localization to presynapse|upregulation of recruitment of presynaptic proteins http://purl.obolibrary.org/obo/GO_1905386 GO:1905387 biolink:BiologicalProcess response to beta-carotene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus. go.json response to beta,beta-carotene http://purl.obolibrary.org/obo/GO_1905387 GO:1905388 biolink:BiologicalProcess cellular response to beta-carotene Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus. go.json cellular response to beta,beta-carotene http://purl.obolibrary.org/obo/GO_1905388 GO:1905378 biolink:BiologicalProcess cellular response to D-galactose Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus. go.json cellular response to D-Gal|cellular response to D-galacto-hexose http://purl.obolibrary.org/obo/GO_1905378 GO:1905379 biolink:CellularComponent beta-N-acetylhexosaminidase complex A protein complex which is capable of beta-N-acetylhexosaminidase activity. go.json HEX A complex|HEX B complex|HEX S complex http://purl.obolibrary.org/obo/GO_1905379 GO:0090578 biolink:CellularComponent RNA polymerase V transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V. go.json RNA polymerase V transcription factor complex http://purl.obolibrary.org/obo/GO_0090578 GO:0090579 biolink:BiologicalProcess obsolete dsDNA loop formation OBSOLETE. The formation and maintenance of DNA loops that juxtapose separated regions on the same dsDNA molecule. go.json chromatin looping|dsDNA looping True http://purl.obolibrary.org/obo/GO_0090579 GO:0090572 biolink:CellularComponent RNA polymerase III transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter. go.json http://purl.obolibrary.org/obo/GO_0090572 GO:0090573 biolink:CellularComponent RNA polymerase IV transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter. go.json http://purl.obolibrary.org/obo/GO_0090573 GO:0090570 biolink:CellularComponent RNA polymerase I transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter. go.json http://purl.obolibrary.org/obo/GO_0090570 GO:0090571 biolink:CellularComponent RNA polymerase II transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_0090571 GO:0090576 biolink:CellularComponent RNA polymerase III transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III. go.json RNA polymerase III transcription factor complex http://purl.obolibrary.org/obo/GO_0090576 GO:0090577 biolink:CellularComponent RNA polymerase IV transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV. go.json RNA polymerase IV transcription factor complex http://purl.obolibrary.org/obo/GO_0090577 GO:0090574 biolink:CellularComponent RNA polymerase V transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter. go.json http://purl.obolibrary.org/obo/GO_0090574 GO:0090575 biolink:CellularComponent RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. go.json RNA polymerase II transcription factor complex http://purl.obolibrary.org/obo/GO_0090575 GO:1905390 biolink:BiologicalProcess cellular response to leukotriene B4 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus. go.json cellular response to LTB4 http://purl.obolibrary.org/obo/GO_1905390 GO:1905391 biolink:BiologicalProcess regulation of protein localization to cell division site involved in cell separation after cytokinesis Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis. go.json regulation of protein localisation to cell division site involved in cell separation after cytokinesis|regulation of protein localisation to cell division site involved in cell separation following cytokinesis|regulation of protein localisation to cell division site involved in cytokinetic cell separation|regulation of protein localisation to cell division site involved in mitotic cytokinetic cell separation http://purl.obolibrary.org/obo/GO_1905391 GO:1905392 biolink:BiologicalProcess plant organ morphogenesis The developmental process by which a plant organ is generated and organized. go.json http://purl.obolibrary.org/obo/GO_1905392 GO:1905393 biolink:BiologicalProcess plant organ formation The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_1905393 GO:1905394 biolink:MolecularActivity retromer complex binding Binding to a retromer complex. go.json http://purl.obolibrary.org/obo/GO_1905394 GO:1905395 biolink:BiologicalProcess response to flavonoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus. go.json http://purl.obolibrary.org/obo/GO_1905395 GO:1905396 biolink:BiologicalProcess cellular response to flavonoid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus. go.json http://purl.obolibrary.org/obo/GO_1905396 GO:1905397 biolink:BiologicalProcess activated CD8-positive, alpha-beta T cell apoptotic process Any apoptotic process in an activated CD8-positive, alpha-beta T cell. go.json activated CD8-positive, alpha-beta T cell apoptosis|activated CD8-positive, alpha-beta T lymphocyte apoptosis|activated CD8-positive, alpha-beta T lymphocyte apoptotic process|activated CD8-positive, alpha-beta T-cell apoptosis|activated CD8-positive, alpha-beta T-cell apoptotic process|activated CD8-positive, alpha-beta T-lymphocyte apoptosis|activated CD8-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905397 GO:1905398 biolink:BiologicalProcess activated CD4-positive, alpha-beta T cell apoptotic process Any apoptotic process in an activated CD4-positive, alpha-beta T cell. go.json activated CD4-positive, alpha-beta T cell apoptosis|activated CD4-positive, alpha-beta T lymphocyte apoptosis|activated CD4-positive, alpha-beta T lymphocyte apoptotic process|activated CD4-positive, alpha-beta T-cell apoptosis|activated CD4-positive, alpha-beta T-cell apoptotic process|activated CD4-positive, alpha-beta T-lymphocyte apoptosis|activated CD4-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905398 GO:1905399 biolink:BiologicalProcess regulation of activated CD4-positive, alpha-beta T cell apoptotic process Any process that modulates the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process. go.json regulation of activated CD4-positive, alpha-beta T cell apoptosis|regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|regulation of activated CD4-positive, alpha-beta T-cell apoptosis|regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905399 GO:0090547 biolink:BiologicalProcess response to low humidity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere. go.json http://purl.obolibrary.org/obo/GO_0090547 GO:1905389 biolink:BiologicalProcess response to leukotriene B4 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus. go.json response to LTB4 http://purl.obolibrary.org/obo/GO_1905389 GO:0090548 biolink:BiologicalProcess response to nitrate starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate. go.json http://purl.obolibrary.org/obo/GO_0090548 GO:0090545 biolink:CellularComponent CHD-type complex A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. go.json http://purl.obolibrary.org/obo/GO_0090545 GO:0090546 biolink:BiologicalProcess chlorophyll fluorescence The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light. go.json http://purl.obolibrary.org/obo/GO_0090546 GO:0090549 biolink:BiologicalProcess response to carbon starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source. go.json http://purl.obolibrary.org/obo/GO_0090549 GO:0090540 biolink:BiologicalProcess bacterial cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria. go.json bacterial cellulose biosynthesis http://purl.obolibrary.org/obo/GO_0090540 GO:0090543 biolink:CellularComponent Flemming body A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. go.json Midbody ring http://purl.obolibrary.org/obo/GO_0090543 GO:0090544 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090544 GO:0090541 biolink:MolecularActivity MIT domain binding Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. go.json http://purl.obolibrary.org/obo/GO_0090541 GO:0090542 biolink:MolecularActivity ELYC domain binding Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC. go.json http://purl.obolibrary.org/obo/GO_0090542 GO:0090558 biolink:BiologicalProcess plant epidermis development The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0090558 GO:0090559 biolink:BiologicalProcess regulation of membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. go.json http://purl.obolibrary.org/obo/GO_0090559 GO:0090556 biolink:MolecularActivity phosphatidylserine floppase activity Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. RHEA:38567 go.json ATPase-coupled phosphatidylserine transporter activity|ATPase-dependent phosphatidylserine transporter activity|phosphatidylserine floppase activity (cytosolic to exoplasmic leaftlet)|phosphatidylserine-translocating ATPase activity http://purl.obolibrary.org/obo/GO_0090556 GO:0090557 biolink:BiologicalProcess establishment of endothelial intestinal barrier The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. go.json http://purl.obolibrary.org/obo/GO_0090557 GO:0090550 biolink:BiologicalProcess response to molybdenum starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum. go.json http://purl.obolibrary.org/obo/GO_0090550 GO:0090551 biolink:BiologicalProcess response to manganese starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese. go.json http://purl.obolibrary.org/obo/GO_0090551 GO:0090554 biolink:MolecularActivity phosphatidylcholine floppase activity Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. RHEA:38583 go.json ATP-dependent phosphatidylcholine transporter activity|ATPase-coupled phosphatidylcholine transporter activity|phosphatidylcholine floppase activity (cytosolic to exoplasmic leaftlet)|phosphatidylcholine-translocating ATPase activity http://purl.obolibrary.org/obo/GO_0090554 GO:0090555 biolink:MolecularActivity phosphatidylethanolamine flippase activity Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. RHEA:66132 go.json ATP-dependent phosphatidylethanolamine transporter activity|ATPase-coupled phosphatidylethanolamine transporter activity|phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)|phosphatidylethanolamine-translocating ATPase activity http://purl.obolibrary.org/obo/GO_0090555 GO:0090552 biolink:CellularComponent unicellular trichome apex A cell projection part that is the apical most portion of a unicellular trichome. go.json http://purl.obolibrary.org/obo/GO_0090552 GO:0090553 biolink:CellularComponent unicellular trichome tip A cell projection part that is the apical most portion of a unicellular trichome apex. go.json http://purl.obolibrary.org/obo/GO_0090553 GO:0090580 biolink:MolecularActivity phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand. go.json http://purl.obolibrary.org/obo/GO_0090580 GO:0090589 biolink:MolecularActivity protein-phosphocysteine-trehalose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in). go.json http://purl.obolibrary.org/obo/GO_0090589 GO:0090583 biolink:MolecularActivity protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090583 GO:0090584 biolink:MolecularActivity protein-phosphocysteine-galactitol-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090584 GO:0090581 biolink:MolecularActivity protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090581 GO:0090582 biolink:MolecularActivity protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090582 GO:0090587 biolink:MolecularActivity protein-phosphocysteine-glucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in). go.json http://purl.obolibrary.org/obo/GO_0090587 GO:0090588 biolink:MolecularActivity protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in). go.json http://purl.obolibrary.org/obo/GO_0090588 GO:0090585 biolink:MolecularActivity protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090585 GO:0090586 biolink:MolecularActivity protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in). go.json http://purl.obolibrary.org/obo/GO_0090586 GO:0090590 biolink:MolecularActivity protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090590 GO:0090591 biolink:MolecularActivity protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0090591 GO:0090594 biolink:BiologicalProcess inflammatory response to wounding The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. go.json http://purl.obolibrary.org/obo/GO_0090594 GO:0090595 biolink:MolecularActivity acetyl-CoA:L-lysine N6-acetyltransferase Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H+. go.json http://purl.obolibrary.org/obo/GO_0090595 GO:0090592 biolink:BiologicalProcess DNA synthesis involved in DNA replication Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA. go.json http://purl.obolibrary.org/obo/GO_0090592 GO:0090593 biolink:BiologicalProcess peptidyl-histidine autophosphorylation The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein. go.json http://purl.obolibrary.org/obo/GO_0090593 gocheck_do_not_annotate GO:0090598 biolink:BiologicalProcess male anatomical structure morphogenesis The processes by which anatomical structures that are only present in the male organism are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0090598 GO:0090599 biolink:MolecularActivity alpha-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. EC:3.2.1.20|Reactome:R-HSA-9036727|Reactome:R-HSA-9036729 go.json http://purl.obolibrary.org/obo/GO_0090599 GO:0090596 biolink:BiologicalProcess sensory organ morphogenesis Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json http://purl.obolibrary.org/obo/GO_0090596 GO:0090597 biolink:BiologicalProcess nematode male tail mating organ morphogenesis The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules. go.json http://purl.obolibrary.org/obo/GO_0090597 GO:1905300 biolink:BiologicalProcess positive regulation of intestinal epithelial cell development Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. go.json activation of intestinal epithelial cell development|up regulation of intestinal epithelial cell development|up-regulation of intestinal epithelial cell development|upregulation of intestinal epithelial cell development http://purl.obolibrary.org/obo/GO_1905300 GO:1905310 biolink:BiologicalProcess regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1905310 GO:1905311 biolink:BiologicalProcess negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. go.json down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_1905311 GO:1905301 biolink:BiologicalProcess regulation of macropinocytosis Any process that modulates the frequency, rate or extent of macropinocytosis. go.json regulation of clathrin-independent pinocytosis http://purl.obolibrary.org/obo/GO_1905301 GO:1905302 biolink:BiologicalProcess negative regulation of macropinocytosis Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis. go.json down regulation of macropinocytosis|down-regulation of macropinocytosis|downregulation of macropinocytosis|inhibition of macropinocytosis http://purl.obolibrary.org/obo/GO_1905302 GO:1905303 biolink:BiologicalProcess positive regulation of macropinocytosis Any process that activates or increases the frequency, rate or extent of macropinocytosis. go.json activation of macropinocytosis|up regulation of macropinocytosis|up-regulation of macropinocytosis|upregulation of macropinocytosis http://purl.obolibrary.org/obo/GO_1905303 GO:1905304 biolink:BiologicalProcess regulation of cardiac myofibril assembly Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. go.json regulation of cardiac myofibril development|regulation of cardiac myofibril morphogenesis|regulation of heart myofibril assembly http://purl.obolibrary.org/obo/GO_1905304 GO:1905305 biolink:BiologicalProcess negative regulation of cardiac myofibril assembly Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. go.json down regulation of cardiac myofibril assembly|down regulation of cardiac myofibril development|down regulation of cardiac myofibril morphogenesis|down regulation of heart myofibril assembly|down-regulation of cardiac myofibril assembly|down-regulation of cardiac myofibril development|down-regulation of cardiac myofibril morphogenesis|down-regulation of heart myofibril assembly|downregulation of cardiac myofibril assembly|downregulation of cardiac myofibril development|downregulation of cardiac myofibril morphogenesis|downregulation of heart myofibril assembly|inhibition of cardiac myofibril assembly|inhibition of cardiac myofibril development|inhibition of cardiac myofibril morphogenesis|inhibition of heart myofibril assembly|negative regulation of cardiac myofibril development|negative regulation of cardiac myofibril morphogenesis|negative regulation of heart myofibril assembly http://purl.obolibrary.org/obo/GO_1905305 GO:1905306 biolink:BiologicalProcess positive regulation of cardiac myofibril assembly Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. go.json activation of cardiac myofibril assembly|activation of cardiac myofibril development|activation of cardiac myofibril morphogenesis|activation of heart myofibril assembly|positive regulation of cardiac myofibril development|positive regulation of cardiac myofibril morphogenesis|positive regulation of heart myofibril assembly|up regulation of cardiac myofibril assembly|up regulation of cardiac myofibril development|up regulation of cardiac myofibril morphogenesis|up regulation of heart myofibril assembly|up-regulation of cardiac myofibril assembly|up-regulation of cardiac myofibril development|up-regulation of cardiac myofibril morphogenesis|up-regulation of heart myofibril assembly|upregulation of cardiac myofibril assembly|upregulation of cardiac myofibril development|upregulation of cardiac myofibril morphogenesis|upregulation of heart myofibril assembly http://purl.obolibrary.org/obo/GO_1905306 GO:1905307 biolink:BiologicalProcess response to miconazole Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus. go.json http://purl.obolibrary.org/obo/GO_1905307 GO:1905308 biolink:BiologicalProcess cellular response to miconazole Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus. go.json http://purl.obolibrary.org/obo/GO_1905308 GO:1905309 biolink:BiologicalProcess positive regulation of cohesin loading Any process that activates or increases the frequency, rate or extent of cohesin loading. go.json positive regulation of cohesin association with chromatin|positive regulation of cohesin localization to chromatin http://purl.obolibrary.org/obo/GO_1905309 GO:1905320 biolink:BiologicalProcess regulation of mesenchymal stem cell migration Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration. go.json http://purl.obolibrary.org/obo/GO_1905320 GO:1905321 biolink:BiologicalProcess negative regulation of mesenchymal stem cell migration Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration. go.json down regulation of mesenchymal stem cell migration|down-regulation of mesenchymal stem cell migration|downregulation of mesenchymal stem cell migration|inhibition of mesenchymal stem cell migration http://purl.obolibrary.org/obo/GO_1905321 GO:1905322 biolink:BiologicalProcess positive regulation of mesenchymal stem cell migration Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration. go.json activation of mesenchymal stem cell migration|up regulation of mesenchymal stem cell migration|up-regulation of mesenchymal stem cell migration|upregulation of mesenchymal stem cell migration http://purl.obolibrary.org/obo/GO_1905322 GO:1905312 biolink:BiologicalProcess positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. go.json activation of cardiac neural crest cell migration involved in outflow tract morphogenesis|up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_1905312 GO:1905313 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in heart development OBSOLETE. Any transforming growth factor beta receptor signaling pathway that is involved in heart development. go.json TGF-beta receptor signaling pathway involved in cardiac development|TGF-beta receptor signaling pathway involved in dorsal vessel development|TGF-beta receptor signaling pathway involved in heart development|TGF-beta receptor signalling pathway involved in cardiac development|TGF-beta receptor signalling pathway involved in dorsal vessel development|TGF-beta receptor signalling pathway involved in heart development|TGFbeta receptor signaling pathway involved in cardiac development|TGFbeta receptor signaling pathway involved in dorsal vessel development|TGFbeta receptor signaling pathway involved in heart development|TGFbeta receptor signalling pathway involved in cardiac development|TGFbeta receptor signalling pathway involved in dorsal vessel development|TGFbeta receptor signalling pathway involved in heart development|transforming growth factor beta receptor signaling pathway involved in cardiac development|transforming growth factor beta receptor signaling pathway involved in dorsal vessel development|transforming growth factor beta receptor signalling pathway involved in cardiac development|transforming growth factor beta receptor signalling pathway involved in dorsal vessel development|transforming growth factor beta receptor signalling pathway involved in heart development True http://purl.obolibrary.org/obo/GO_1905313 GO:1905314 biolink:BiologicalProcess semi-lunar valve development The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure. go.json semilunar valve development|semilunar valves development http://purl.obolibrary.org/obo/GO_1905314 GO:1905315 biolink:BiologicalProcess cell proliferation involved in endocardial cushion morphogenesis Any cell proliferation that is involved in endocardial cushion morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1905315 GO:1905316 biolink:BiologicalProcess superior endocardial cushion morphogenesis The developmental process by which a superior endocardial cushion is generated and organized. go.json dorsal endocardial cushion morphogenesis http://purl.obolibrary.org/obo/GO_1905316 GO:1905317 biolink:BiologicalProcess inferior endocardial cushion morphogenesis The developmental process by which an inferior endocardial cushion is generated and organized. go.json ventral endocardial cushion morphogenesis http://purl.obolibrary.org/obo/GO_1905317 GO:1905318 biolink:BiologicalProcess meiosis I spindle assembly checkpoint signaling Any spindle assembly checkpoint that is involved in meiosis I. go.json meiosis I spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_1905318 GO:1905319 biolink:BiologicalProcess mesenchymal stem cell migration The orderly movement of a mesenchymal stem cell from one site to another. go.json http://purl.obolibrary.org/obo/GO_1905319 GO:1905330 biolink:BiologicalProcess regulation of morphogenesis of an epithelium Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. go.json regulation of epithelium morphogenesis http://purl.obolibrary.org/obo/GO_1905330 GO:1905331 biolink:BiologicalProcess negative regulation of morphogenesis of an epithelium Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. go.json down regulation of epithelium morphogenesis|down regulation of morphogenesis of an epithelium|down-regulation of epithelium morphogenesis|down-regulation of morphogenesis of an epithelium|downregulation of epithelium morphogenesis|downregulation of morphogenesis of an epithelium|inhibition of epithelium morphogenesis|inhibition of morphogenesis of an epithelium|negative regulation of epithelium morphogenesis http://purl.obolibrary.org/obo/GO_1905331 GO:1905332 biolink:BiologicalProcess positive regulation of morphogenesis of an epithelium Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. go.json activation of epithelium morphogenesis|activation of morphogenesis of an epithelium|positive regulation of epithelium morphogenesis|up regulation of epithelium morphogenesis|up regulation of morphogenesis of an epithelium|up-regulation of epithelium morphogenesis|up-regulation of morphogenesis of an epithelium|upregulation of epithelium morphogenesis|upregulation of morphogenesis of an epithelium http://purl.obolibrary.org/obo/GO_1905332 GO:1905333 biolink:BiologicalProcess regulation of gastric motility Any process that modulates the frequency, rate or extent of gastric motility. go.json http://purl.obolibrary.org/obo/GO_1905333 GO:0090525 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090525 GO:1905323 biolink:BiologicalProcess telomerase holoenzyme complex assembly The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex. go.json telomerase holoenzyme complex formation http://purl.obolibrary.org/obo/GO_1905323 GO:1905324 biolink:BiologicalProcess telomere-telomerase complex assembly The aggregation, arrangement and bonding together of a set of components to form a telomere-telomerase complex. go.json telomere-telomerase complex formation http://purl.obolibrary.org/obo/GO_1905324 GO:0090526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090526 GO:1905325 biolink:BiologicalProcess regulation of meiosis I spindle assembly checkpoint Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint. go.json http://purl.obolibrary.org/obo/GO_1905325 GO:0090523 biolink:MolecularActivity cytochrome-b5 reductase activity, acting on NADPH Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5). RHEA:64576 go.json cytochrome-b5 reductase activity http://purl.obolibrary.org/obo/GO_0090523 GO:0090524 biolink:MolecularActivity cytochrome-b5 reductase activity, acting on NADH Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5). go.json cytochrome b5 reductase activity http://purl.obolibrary.org/obo/GO_0090524 GO:1905326 biolink:BiologicalProcess positive regulation of meiosis I spindle assembly checkpoint Any process that activates or increases the frequency, rate or extent of the meiosis I spindle assembly checkpoint. go.json activation of meiosis I spindle assembly checkpoint|up regulation of meiosis I spindle assembly checkpoint|up-regulation of meiosis I spindle assembly checkpoint|upregulation of meiosis I spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_1905326 GO:0090529 biolink:BiologicalProcess cell septum assembly The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. go.json cell septum assembly involved in cell cycle cytokinesis http://purl.obolibrary.org/obo/GO_0090529 GO:1905327 biolink:BiologicalProcess tracheoesophageal septum formation The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts. go.json esophagotracheal septum formation|tracheoesophageal ridges formation http://purl.obolibrary.org/obo/GO_1905327 GO:1905328 biolink:BiologicalProcess plant septum development The process whose specific outcome is the progression of a septum over time, from its formation to the mature structure. go.json dissepiment development http://purl.obolibrary.org/obo/GO_1905328 GO:1905329 biolink:BiologicalProcess sphingoid long-chain base transport The directed movement of a sphingoid long-chain base, sometimes referred to as long-chain base, or sphingoid base, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sphingoid long-chain bases are long-chain aliphatic amines that are the fundamental building blocks of sphingolipids. The main mammalian sphingoid long-chain bases are dihydrosphingosine and sphingosine, while dihydrosphingosine and phytosphingosine are the main sphingoid long-chain bases in yeast. go.json dihydrosphingosine transport|long-chain base transport|phytosphingosine transport|sphingoid base(1+) transport|sphingoid transport|sphingosine transport http://purl.obolibrary.org/obo/GO_1905329 GO:0090527 biolink:BiologicalProcess obsolete actin filament reorganization OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments. go.json True http://purl.obolibrary.org/obo/GO_0090527 GO:0090528 biolink:BiologicalProcess smooth septate junction assembly The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions. go.json http://purl.obolibrary.org/obo/GO_0090528 GO:0090521 biolink:BiologicalProcess podocyte cell migration The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell. go.json glomerular visceral epithelial cell migration http://purl.obolibrary.org/obo/GO_0090521 GO:0090522 biolink:BiologicalProcess vesicle tethering involved in exocytosis The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. go.json vesicle tethering to plasma membrane http://purl.obolibrary.org/obo/GO_0090522 GO:0090520 biolink:BiologicalProcess sphingolipid mediated signaling pathway The series of molecular signals mediated by a sphingolipid. go.json ceramide 1-phosphate signaling pathway|ceramide signaling pathway|sphingolipid mediated signal transduction|sphingolipid signaling pathway|sphingolipid-mediated signaling pathway|sphingosine signaling pathway http://purl.obolibrary.org/obo/GO_0090520 GO:1905340 biolink:BiologicalProcess regulation of protein localization to kinetochore Any process that modulates the frequency, rate or extent of protein localization to kinetochore. go.json regulation of condensin localization to kinetochore|regulation of protein localisation to kinetochore http://purl.obolibrary.org/obo/GO_1905340 GO:1905341 biolink:BiologicalProcess negative regulation of protein localization to kinetochore Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to kinetochore. go.json down regulation of condensin localization to kinetochore|down regulation of protein localisation to kinetochore|down regulation of protein localization to kinetochore|down-regulation of condensin localization to kinetochore|down-regulation of protein localisation to kinetochore|down-regulation of protein localization to kinetochore|downregulation of condensin localization to kinetochore|downregulation of protein localisation to kinetochore|downregulation of protein localization to kinetochore|inhibition of condensin localization to kinetochore|inhibition of protein localisation to kinetochore|inhibition of protein localization to kinetochore|negative regulation of condensin localization to kinetochore|negative regulation of protein localisation to kinetochore http://purl.obolibrary.org/obo/GO_1905341 GO:1905342 biolink:BiologicalProcess positive regulation of protein localization to kinetochore Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore. go.json activation of condensin localization to kinetochore|activation of protein localisation to kinetochore|activation of protein localization to kinetochore|positive regulation of condensin localization to kinetochore|positive regulation of protein localisation to kinetochore|up regulation of condensin localization to kinetochore|up regulation of protein localisation to kinetochore|up regulation of protein localization to kinetochore|up-regulation of condensin localization to kinetochore|up-regulation of protein localisation to kinetochore|up-regulation of protein localization to kinetochore|upregulation of condensin localization to kinetochore|upregulation of protein localisation to kinetochore|upregulation of protein localization to kinetochore http://purl.obolibrary.org/obo/GO_1905342 GO:1905343 biolink:BiologicalProcess regulation of cohesin unloading Any process that modulates the frequency, rate or extent of cohesin unloading. go.json http://purl.obolibrary.org/obo/GO_1905343 gocheck_do_not_annotate GO:1905344 biolink:BiologicalProcess prostaglandin catabolic process The chemical reactions and pathways resulting in the breakdown of prostaglandin. go.json prostaglandin breakdown|prostaglandin catabolism|prostaglandin degradation http://purl.obolibrary.org/obo/GO_1905344 GO:0090536 biolink:CellularComponent NoRC complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters. go.json http://purl.obolibrary.org/obo/GO_0090536 GO:1905334 biolink:MolecularActivity Swi5-Sfr1 complex binding Binding to a Swi5-Sfr1 complex. go.json Sae3-Mei5 complex binding http://purl.obolibrary.org/obo/GO_1905334 GO:0090537 biolink:CellularComponent CERF complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters. go.json http://purl.obolibrary.org/obo/GO_0090537 GO:1905335 biolink:BiologicalProcess regulation of aggrephagy Any process that modulates the frequency, rate or extent of aggrephagy. go.json http://purl.obolibrary.org/obo/GO_1905335 GO:1905336 biolink:BiologicalProcess negative regulation of aggrephagy Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy. go.json down regulation of aggrephagy|down-regulation of aggrephagy|downregulation of aggrephagy|inhibition of aggrephagy http://purl.obolibrary.org/obo/GO_1905336 GO:0090534 biolink:CellularComponent calcium ion-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in). go.json http://purl.obolibrary.org/obo/GO_0090534 GO:0090535 biolink:CellularComponent WICH complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair. go.json http://purl.obolibrary.org/obo/GO_0090535 GO:1905337 biolink:BiologicalProcess positive regulation of aggrephagy Any process that activates or increases the frequency, rate or extent of aggrephagy. go.json activation of aggrephagy|up regulation of aggrephagy|up-regulation of aggrephagy|upregulation of aggrephagy http://purl.obolibrary.org/obo/GO_1905337 GO:1905338 biolink:BiologicalProcess negative regulation of cohesin unloading Any process that stops, prevents or reduces the frequency, rate or extent of cohesin unloading. go.json down regulation of cohesin unloading|down-regulation of cohesin unloading|downregulation of cohesin unloading|inhibition of cohesin unloading http://purl.obolibrary.org/obo/GO_1905338 gocheck_do_not_annotate GO:1905339 biolink:BiologicalProcess positive regulation of cohesin unloading Any process that activates or increases the frequency, rate or extent of cohesin unloading. go.json activation of cohesin unloading|up regulation of cohesin unloading|up-regulation of cohesin unloading|upregulation of cohesin unloading http://purl.obolibrary.org/obo/GO_1905339 gocheck_do_not_annotate GO:0090538 biolink:BiologicalProcess peptide pheromone secretion The regulated release of a peptide pheromone from a cell. go.json http://purl.obolibrary.org/obo/GO_0090538 GO:0090539 biolink:BiologicalProcess peptide pheromone export by transmembrane transport The directed movement of a peptide pheromone across a membrane and out of a cell. go.json peptide pheromone export by membrane transport http://purl.obolibrary.org/obo/GO_0090539 GO:0090532 biolink:BiologicalProcess L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate. go.json L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate http://purl.obolibrary.org/obo/GO_0090532 GO:0090533 biolink:CellularComponent cation-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). go.json http://purl.obolibrary.org/obo/GO_0090533 GO:0090530 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090530 GO:0090531 biolink:BiologicalProcess L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose. BioCyc:PWY-882 go.json L-ascorbic acid biosynthesis via GDP-alpha-D-mannose|Smirnoff-Wheeler's pathway http://purl.obolibrary.org/obo/GO_0090531 GO:1905350 biolink:BiologicalProcess Y-shaped link assembly The aggregation, arrangement and bonding together of a set of components to form a Y-shaped link. Two distinct protein complexes are known to be involved in proper linker assembly: the MKS complex and the NPHP complex. Improper assembly of Y-shaped links may cause malfunctioning of the transition zone as a molecular gate. go.json Y-link assembly|Y-link formation|Y-link structure assembly|Y-link structure formation|Y-shaped assemblage assembly|Y-shaped assemblage formation|Y-shaped fiber assembly|Y-shaped fiber formation|Y-shaped fibre assembly|Y-shaped fibre formation|Y-shaped link formation|Y-shaped linker assembly|Y-shaped linker formation|membrane-microtubule complex assembly|membrane-microtubule complex formation http://purl.obolibrary.org/obo/GO_1905350 GO:1905351 biolink:BiologicalProcess pericyte cell migration The orderly movement of a pericyte cell from one site to another. go.json http://purl.obolibrary.org/obo/GO_1905351 GO:1905352 biolink:BiologicalProcess ciliary necklace assembly The aggregation, arrangement and bonding together of a set of components to form a ciliary necklace. go.json cilial necklace assembly|cilial necklace formation|ciliary necklace formation|cilium necklace assembly|cilium necklace formation http://purl.obolibrary.org/obo/GO_1905352 GO:1905353 biolink:BiologicalProcess ciliary transition fiber assembly The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber. go.json centriolar distal appendage assembly|centriolar distal appendage formation|cilial transition fiber assembly|cilial transition fiber formation|cilial transition fibre assembly|cilial transition fibre formation|ciliary transition fiber formation|ciliary transition fibre assembly|ciliary transition fibre formation|cilium transition fiber assembly|cilium transition fiber formation|cilium transition fibre assembly|cilium transition fibre formation|distal appendage of basal body assembly|distal appendage of basal body formation|distal appendage of centriole assembly|distal appendage of centriole formation|distal appendage of mother centriole assembly|distal appendage of mother centriole formation http://purl.obolibrary.org/obo/GO_1905353 GO:1905354 biolink:CellularComponent exoribonuclease complex A protein complex which is capable of exoribonuclease activity. go.json http://purl.obolibrary.org/obo/GO_1905354 GO:1905355 biolink:BiologicalProcess spine apparatus assembly The aggregation, arrangement and bonding together of a set of components to form a spine apparatus. go.json dense material assembly|dense material formation|spine apparatus formation http://purl.obolibrary.org/obo/GO_1905355 GO:1905345 biolink:BiologicalProcess protein localization to cleavage furrow A process in which a protein is transported to, or maintained in, a location within a cleavage furrow. go.json protein localisation in cleavage furrow|protein localisation to cleavage furrow|protein localization in cleavage furrow http://purl.obolibrary.org/obo/GO_1905345 GO:0090503 biolink:BiologicalProcess obsolete RNA phosphodiester bond hydrolysis, exonucleolytic OBSOLETE. The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. go.json True http://purl.obolibrary.org/obo/GO_0090503 GO:1905346 biolink:BiologicalProcess protein localization to cleavage furrow rim A process in which a protein is transported to, or maintained in, a location within a cleavage furrow rim. go.json protein localisation in cleavage furrow rim|protein localisation to cleavage furrow rim|protein localization in cleavage furrow rim http://purl.obolibrary.org/obo/GO_1905346 GO:0090504 biolink:BiologicalProcess epiboly The expansion of one cell sheet over other cells or yolk. go.json http://purl.obolibrary.org/obo/GO_0090504 GO:0090501 biolink:BiologicalProcess obsolete RNA phosphodiester bond hydrolysis OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. go.json True http://purl.obolibrary.org/obo/GO_0090501 GO:1905347 biolink:CellularComponent endodeoxyribonuclease complex A protein complex which is capable of endodeoxyribonuclease activity. go.json Mus81-Eme1 complex|Mus81-Eme2 complex http://purl.obolibrary.org/obo/GO_1905347 GO:0090502 biolink:BiologicalProcess obsolete RNA phosphodiester bond hydrolysis, endonucleolytic OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. go.json True http://purl.obolibrary.org/obo/GO_0090502 GO:1905348 biolink:CellularComponent endonuclease complex A protein complex which is capable of endonuclease activity. go.json http://purl.obolibrary.org/obo/GO_1905348 GO:1905349 biolink:BiologicalProcess ciliary transition zone assembly The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. go.json cilial transition zone assembly|cilial transition zone formation|ciliary transition zone formation|cilium transition zone assembly|cilium transition zone formation http://purl.obolibrary.org/obo/GO_1905349 GO:0090507 biolink:BiologicalProcess phenylethylamine metabolic process involved in synaptic transmission The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0090507 GO:0090508 biolink:BiologicalProcess phenylethylamine biosynthetic process involved in synaptic transmission The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0090508 GO:0090505 biolink:BiologicalProcess epiboly involved in wound healing The expansion of one cell sheet over other cells involved in wound healing. go.json http://purl.obolibrary.org/obo/GO_0090505 GO:0090506 biolink:BiologicalProcess axillary shoot meristem initiation A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf. go.json axillary bud meristem initiation http://purl.obolibrary.org/obo/GO_0090506 GO:0090500 biolink:BiologicalProcess endocardial cushion to mesenchymal transition A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0090500 GO:1905360 biolink:CellularComponent GTPase complex A protein complex which is capable of GTPase activity. go.json HRAS-SOS1 complex|RASH-SOS1 complex http://purl.obolibrary.org/obo/GO_1905360 GO:1905361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905361 GO:0090509 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090509 GO:1905362 biolink:BiologicalProcess negative regulation of endosomal vesicle fusion Any process that stops, prevents or reduces the frequency, rate or extent of endosomal vesicle fusion. go.json down regulation of endosomal vesicle fusion|down regulation of endosome vesicle fusion|down-regulation of endosomal vesicle fusion|down-regulation of endosome vesicle fusion|downregulation of endosomal vesicle fusion|downregulation of endosome vesicle fusion|inhibition of endosomal vesicle fusion|inhibition of endosome vesicle fusion|negative regulation of endosome vesicle fusion http://purl.obolibrary.org/obo/GO_1905362 GO:1905363 biolink:BiologicalProcess positive regulation of endosomal vesicle fusion Any process that activates or increases the frequency, rate or extent of endosomal vesicle fusion. go.json activation of endosomal vesicle fusion|activation of endosome vesicle fusion|positive regulation of endosome vesicle fusion|up regulation of endosomal vesicle fusion|up regulation of endosome vesicle fusion|up-regulation of endosomal vesicle fusion|up-regulation of endosome vesicle fusion|upregulation of endosomal vesicle fusion|upregulation of endosome vesicle fusion http://purl.obolibrary.org/obo/GO_1905363 GO:1905364 biolink:BiologicalProcess regulation of endosomal vesicle fusion Any process that modulates the frequency, rate or extent of endosomal vesicle fusion. go.json regulation of endosome vesicle fusion http://purl.obolibrary.org/obo/GO_1905364 GO:1905365 biolink:BiologicalProcess regulation of intralumenal vesicle formation Any process that modulates the frequency, rate or extent of intralumenal vesicle formation. go.json regulation of endosome membrane budding http://purl.obolibrary.org/obo/GO_1905365 GO:1905366 biolink:BiologicalProcess negative regulation of intralumenal vesicle formation Any process that stops, prevents or reduces the frequency, rate or extent of intralumenal vesicle formation. go.json down regulation of endosome membrane budding|down regulation of intralumenal vesicle formation|down-regulation of endosome membrane budding|down-regulation of intralumenal vesicle formation|downregulation of endosome membrane budding|downregulation of intralumenal vesicle formation|inhibition of endosome membrane budding|inhibition of intralumenal vesicle formation|negative regulation of endosome membrane budding http://purl.obolibrary.org/obo/GO_1905366 GO:1905356 biolink:BiologicalProcess regulation of snRNA pseudouridine synthesis Any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis. go.json http://purl.obolibrary.org/obo/GO_1905356 GO:0090514 biolink:BiologicalProcess L-tyrosine transmembrane import into vacuole The directed movement of L-tyrosine into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0090514 GO:1905357 biolink:BiologicalProcess negative regulation of snRNA pseudouridine synthesis Any process that stops, prevents or reduces the frequency, rate or extent of snRNA pseudouridine synthesis. go.json down regulation of snRNA pseudouridine synthesis|down-regulation of snRNA pseudouridine synthesis|downregulation of snRNA pseudouridine synthesis|inhibition of snRNA pseudouridine synthesis http://purl.obolibrary.org/obo/GO_1905357 GO:0090515 biolink:BiologicalProcess L-glutamate transmembrane import into vacuole The directed movement of L-glutamate into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0090515 GO:1905358 biolink:BiologicalProcess positive regulation of snRNA pseudouridine synthesis Any process that activates or increases the frequency, rate or extent of snRNA pseudouridine synthesis. go.json activation of snRNA pseudouridine synthesis|up regulation of snRNA pseudouridine synthesis|up-regulation of snRNA pseudouridine synthesis|upregulation of snRNA pseudouridine synthesis http://purl.obolibrary.org/obo/GO_1905358 GO:0090512 biolink:CellularComponent eisosome membrane domain/MCC A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins. go.json http://purl.obolibrary.org/obo/GO_0090512 GO:1905359 biolink:BiologicalProcess protein localization to meiotic spindle A process in which a protein is transported to, or maintained in, a location within a meiotic spindle. go.json protein localisation to meiotic spindle http://purl.obolibrary.org/obo/GO_1905359 GO:0090513 biolink:BiologicalProcess L-histidine transmembrane import into vacuole The directed movement of L-histidine into the vacuole across the vacuolar membrane. go.json histidine transmembrane import into vacuole|vacuolar histidine import http://purl.obolibrary.org/obo/GO_0090513 GO:0090518 biolink:BiologicalProcess L-arginine transmembrane import into vacuole The directed movement of L-arginine into the vacuole across the vacuolar membrane. go.json arginine transmembrane import into vacuole|vacuolar arginine import http://purl.obolibrary.org/obo/GO_0090518 GO:0090519 biolink:BiologicalProcess anoxia protection Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia. go.json http://purl.obolibrary.org/obo/GO_0090519 GO:0090516 biolink:BiologicalProcess L-serine transmembrane import into vacuole The directed movement of L-serine into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0090516 GO:0090517 biolink:BiologicalProcess L-lysine transmembrane import into vacuole The directed movement of L-lysine into the vacuole across the vacuolar membrane. go.json lysine transmembrane import into vacuole|vacuolar lysine import http://purl.obolibrary.org/obo/GO_0090517 GO:0090510 biolink:BiologicalProcess anticlinal cell division A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file. go.json http://purl.obolibrary.org/obo/GO_0090510 GO:0090511 biolink:BiologicalProcess periclinal cell division A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file. go.json http://purl.obolibrary.org/obo/GO_0090511 GO:2000346 biolink:BiologicalProcess negative regulation of hepatocyte proliferation Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation. go.json http://purl.obolibrary.org/obo/GO_2000346 GO:2000347 biolink:BiologicalProcess positive regulation of hepatocyte proliferation Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation. go.json http://purl.obolibrary.org/obo/GO_2000347 GO:2000348 biolink:BiologicalProcess regulation of CD40 signaling pathway Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway. go.json regulation of CD40 signalling pathway http://purl.obolibrary.org/obo/GO_2000348 GO:2000349 biolink:BiologicalProcess negative regulation of CD40 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway. go.json negative regulation of CD40 signalling pathway http://purl.obolibrary.org/obo/GO_2000349 GO:0016507 biolink:CellularComponent mitochondrial fatty acid beta-oxidation multienzyme complex A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. go.json fatty acid beta-oxidation multienzyme complex|trifunctional enzyme http://purl.obolibrary.org/obo/GO_0016507 GO:0016508 biolink:MolecularActivity obsolete long-chain-enoyl-CoA hydratase activity OBSOLETE. Catalysis of the reaction: a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. go.json long-chain enoyl coenzyme A hydratase activity|long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity True http://purl.obolibrary.org/obo/GO_0016508 GO:0016509 biolink:MolecularActivity long-chain-3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. EC:1.1.1.211|MetaCyc:1.1.1.211-RXN|RHEA:52656 go.json LCHAD|beta-hydroxyacyl-CoA dehydrogenase activity|long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity|long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016509 GO:0016503 biolink:MolecularActivity pheromone receptor activity Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior. go.json http://purl.obolibrary.org/obo/GO_0016503 GO:0016504 biolink:MolecularActivity peptidase activator activity Binds to and increases the activity of a peptidase. Reactome:R-HSA-168865 go.json protease activator activity http://purl.obolibrary.org/obo/GO_0016504 GO:2000340 biolink:BiologicalProcess positive regulation of chemokine (C-X-C motif) ligand 1 production Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. go.json positive regulation of CXCL1 production|positive regulation of KC production|positive regulation of SCYB1 production|positive regulation of keratinocyte derived chemokine production http://purl.obolibrary.org/obo/GO_2000340 GO:0016505 biolink:MolecularActivity peptidase activator activity involved in apoptotic process Binds to and increases the activity of a peptidase that is involved in the apoptotic process. go.json apoptotic protease activator activity http://purl.obolibrary.org/obo/GO_0016505 GO:2000341 biolink:BiologicalProcess regulation of chemokine (C-X-C motif) ligand 2 production Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. go.json chemokine (C-C motif) ligand 2 secretion|regulation of CCL2 secretion|regulation of CXCL2 production|regulation of MIP-2 production|regulation of MIP2 production|regulation of SCYB2 production|regulation of chemokine (C-C motif) ligand 2 secretion http://purl.obolibrary.org/obo/GO_2000341 GO:0016506 biolink:MolecularActivity obsolete apoptosis activator activity OBSOLETE. The function held by products which directly activate any step in the process of apoptosis. go.json apoptosis activator activity True http://purl.obolibrary.org/obo/GO_0016506 GO:2000342 biolink:BiologicalProcess negative regulation of chemokine (C-X-C motif) ligand 2 production Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. go.json inhibition of CCL2 secretion|inhibition of chemokine (C-C motif) ligand 2 secretion|negative regulation of CXCL2 production|negative regulation of MIP-2 production|negative regulation of MIP2 production|negative regulation of SCYB2 production|negative regulation of chemokine (C-C motif) ligand 2 secretion http://purl.obolibrary.org/obo/GO_2000342 GO:2000343 biolink:BiologicalProcess positive regulation of chemokine (C-X-C motif) ligand 2 production Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. go.json positive regulation of CCL2 secretion|positive regulation of CXCL2 production|positive regulation of MIP-2 production|positive regulation of MIP2 production|positive regulation of SCYB2 production|positive regulation of chemokine (C-C motif) ligand 2 secretion http://purl.obolibrary.org/obo/GO_2000343 GO:0016500 biolink:MolecularActivity protein-hormone receptor activity Combining with a protein hormone to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0016500 GO:2000344 biolink:BiologicalProcess positive regulation of acrosome reaction Any process that activates or increases the frequency, rate or extent of the acrosome reaction. go.json http://purl.obolibrary.org/obo/GO_2000344 GO:0016501 biolink:MolecularActivity prostacyclin receptor activity Combining with prostacyclin (PGI(2)) to initiate a change in cell activity. go.json PGI receptor activity|PGI(2) receptor activity|prostaglandin I receptor activity http://purl.obolibrary.org/obo/GO_0016501 GO:0016502 biolink:MolecularActivity nucleotide receptor activity Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. go.json http://purl.obolibrary.org/obo/GO_0016502 GO:2000345 biolink:BiologicalProcess regulation of hepatocyte proliferation Any process that modulates the frequency, rate or extent of hepatocyte proliferation. go.json http://purl.obolibrary.org/obo/GO_2000345 GO:2000357 biolink:BiologicalProcess negative regulation of kidney smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000357 GO:2000358 biolink:BiologicalProcess positive regulation of kidney smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000358 GO:2000359 biolink:BiologicalProcess regulation of binding of sperm to zona pellucida Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida. go.json regulation of ZPG binding http://purl.obolibrary.org/obo/GO_2000359 GO:0016518 biolink:MolecularActivity obsolete interleukin-14 receptor activity OBSOLETE. Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-14 receptor activity|IL-14R True http://purl.obolibrary.org/obo/GO_0016518 GO:0016519 biolink:MolecularActivity gastric inhibitory peptide receptor activity Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein. go.json GIP receptor activity|glucose-dependent insulinotropic polypeptide receptor activity http://purl.obolibrary.org/obo/GO_0016519 GO:0016514 biolink:CellularComponent SWI/SNF complex A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. go.json SWI-SNF complex http://purl.obolibrary.org/obo/GO_0016514 GO:2000350 biolink:BiologicalProcess positive regulation of CD40 signaling pathway Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway. go.json positive regulation of CD40 signalling pathway http://purl.obolibrary.org/obo/GO_2000350 GO:0016515 biolink:MolecularActivity interleukin-13 receptor activity Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-13 receptor activity|IL-13R http://purl.obolibrary.org/obo/GO_0016515 GO:2000351 biolink:BiologicalProcess regulation of endothelial cell apoptotic process Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. go.json regulation of apoptosis of endothelial cells|regulation of endothelial cell apoptosis|regulation of endothelial cell programmed cell death by apoptosis|regulation of killing of endothelial cells|regulation of programmed cell death of endothelial cells by apoptosis|regulation of programmed cell death, endothelial cells http://purl.obolibrary.org/obo/GO_2000351 GO:0016516 biolink:CellularComponent interleukin-4 receptor complex A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor. go.json IL-4 receptor complex http://purl.obolibrary.org/obo/GO_0016516 GO:2000352 biolink:BiologicalProcess negative regulation of endothelial cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. go.json negative regulation of apoptosis of endothelial cells|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell programmed cell death by apoptosis|negative regulation of killing of endothelial cells|negative regulation of programmed cell death of endothelial cells by apoptosis|negative regulation of programmed cell death, endothelial cells http://purl.obolibrary.org/obo/GO_2000352 GO:0016517 biolink:MolecularActivity interleukin-12 receptor activity Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-12 receptor activity|IL-12R http://purl.obolibrary.org/obo/GO_0016517 GO:2000353 biolink:BiologicalProcess positive regulation of endothelial cell apoptotic process Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. go.json positive regulation of apoptosis of endothelial cells|positive regulation of endothelial cell apoptosis|positive regulation of endothelial cell programmed cell death by apoptosis|positive regulation of killing of endothelial cells|positive regulation of programmed cell death of endothelial cells by apoptosis|positive regulation of programmed cell death, endothelial cells http://purl.obolibrary.org/obo/GO_2000353 GO:0016510 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016510 GO:2000354 biolink:BiologicalProcess regulation of ovarian follicle development Any process that modulates the frequency, rate or extent of ovarian follicle development. go.json regulation of follicular phase http://purl.obolibrary.org/obo/GO_2000354 GO:0016511 biolink:MolecularActivity obsolete endothelin-converting enzyme activity OBSOLETE. (Was not defined before being made obsolete). go.json endothelin-converting enzyme activity True http://purl.obolibrary.org/obo/GO_0016511 GO:2000355 biolink:BiologicalProcess negative regulation of ovarian follicle development Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development. go.json negative regulation of follicular phase http://purl.obolibrary.org/obo/GO_2000355 GO:0016512 biolink:MolecularActivity obsolete endothelin-converting enzyme 1 activity OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor. go.json ECE-1 activity|endothelin-converting enzyme 1 activity True http://purl.obolibrary.org/obo/GO_0016512 GO:2000356 biolink:BiologicalProcess regulation of kidney smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000356 GO:0016513 biolink:CellularComponent core-binding factor complex A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. go.json AML1 complex|CBF complex|PEPB2 complex http://purl.obolibrary.org/obo/GO_0016513 GO:2000368 biolink:BiologicalProcess positive regulation of acrosomal vesicle exocytosis Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis. go.json positive regulation of acrosomal granule exocytosis|positive regulation of acrosome exocytosis http://purl.obolibrary.org/obo/GO_2000368 GO:2000369 biolink:BiologicalProcess regulation of clathrin-dependent endocytosis Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. go.json regulation of clathrin coated pit-dependent endocytosis|regulation of clathrin-mediated endocytosis http://purl.obolibrary.org/obo/GO_2000369 GO:2000360 biolink:BiologicalProcess negative regulation of binding of sperm to zona pellucida Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida. go.json negative regulation of ZPG binding http://purl.obolibrary.org/obo/GO_2000360 GO:2000361 biolink:BiologicalProcess regulation of prostaglandin-E synthase activity Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity. go.json regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity|regulation of PGE isomerase activity|regulation of PGE2 isomerase activity|regulation of PGH-PGE isomerase activity|regulation of Prostaglandin-H(2) E-isomerase activity|regulation of endoperoxide isomerase activity|regulation of prostaglandin H-E isomerase activity|regulation of prostaglandin R-prostaglandin E isomerase activity|regulation of prostaglandin endoperoxide E isomerase activity|regulation of prostaglandin endoperoxide E2 isomerase activity|regulation of prostaglandin-H2 E-isomerase activity http://purl.obolibrary.org/obo/GO_2000361 gocheck_do_not_annotate GO:2000362 biolink:BiologicalProcess negative regulation of prostaglandin-E synthase activity Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity. go.json negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity|negative regulation of PGE isomerase activity|negative regulation of PGE2 isomerase activity|negative regulation of PGH-PGE isomerase activity|negative regulation of Prostaglandin-H(2) E-isomerase activity|negative regulation of endoperoxide isomerase activity|negative regulation of prostaglandin H-E isomerase activity|negative regulation of prostaglandin R-prostaglandin E isomerase activity|negative regulation of prostaglandin endoperoxide E isomerase activity|negative regulation of prostaglandin endoperoxide E2 isomerase activity|negative regulation of prostaglandin-H2 E-isomerase activity http://purl.obolibrary.org/obo/GO_2000362 gocheck_do_not_annotate GO:2000363 biolink:BiologicalProcess positive regulation of prostaglandin-E synthase activity Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity. go.json positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity|positive regulation of PGE isomerase activity|positive regulation of PGE2 isomerase activity|positive regulation of PGH-PGE isomerase activity|positive regulation of Prostaglandin-H(2) E-isomerase activity|positive regulation of endoperoxide isomerase activity|positive regulation of prostaglandin H-E isomerase activity|positive regulation of prostaglandin R-prostaglandin E isomerase activity|positive regulation of prostaglandin endoperoxide E isomerase activity|positive regulation of prostaglandin endoperoxide E2 isomerase activity|positive regulation of prostaglandin-H2 E-isomerase activity http://purl.obolibrary.org/obo/GO_2000363 gocheck_do_not_annotate GO:2000364 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000364 GO:2000365 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000365 GO:2000366 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000366 GO:2000367 biolink:BiologicalProcess regulation of acrosomal vesicle exocytosis Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis. go.json regulation of acrosomal granule exocytosis|regulation of acrosome exocytosis http://purl.obolibrary.org/obo/GO_2000367 GO:2000379 biolink:BiologicalProcess positive regulation of reactive oxygen species metabolic process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. go.json positive regulation of ROS metabolic process|positive regulation of reactive oxygen species metabolism http://purl.obolibrary.org/obo/GO_2000379 GO:2000371 biolink:BiologicalProcess regulation of DNA topoisomerase (ATP-hydrolyzing) activity Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. go.json regulation of DNA topoisomerase (ATP-hydrolysing)|regulation of DNA topoisomerase II|regulation of DNA topoisomerase IV activity|regulation of DNA topoisomerase type II activity|regulation of deoxyribonucleate topoisomerase|regulation of deoxyribonucleic topoisomerase activity|regulation of topoisomerase|regulation of topoisomerase II|regulation of type II DNA topoisomerase activity http://purl.obolibrary.org/obo/GO_2000371 gocheck_do_not_annotate GO:2000372 biolink:BiologicalProcess negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. go.json negative regulation of DNA topoisomerase (ATP-hydrolysing)|negative regulation of DNA topoisomerase II|negative regulation of DNA topoisomerase IV activity|negative regulation of DNA topoisomerase type II activity|negative regulation of deoxyribonucleate topoisomerase|negative regulation of deoxyribonucleic topoisomerase activity|negative regulation of topoisomerase|negative regulation of topoisomerase II|negative regulation of type II DNA topoisomerase activity http://purl.obolibrary.org/obo/GO_2000372 gocheck_do_not_annotate GO:2000373 biolink:BiologicalProcess positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. go.json positive regulation of DNA topoisomerase (ATP-hydrolysing)|positive regulation of DNA topoisomerase II|positive regulation of DNA topoisomerase IV activity|positive regulation of DNA topoisomerase type II activity|positive regulation of deoxyribonucleate topoisomerase|positive regulation of deoxyribonucleic topoisomerase activity|positive regulation of topoisomerase|positive regulation of topoisomerase II|positive regulation of type II DNA topoisomerase activity http://purl.obolibrary.org/obo/GO_2000373 gocheck_do_not_annotate GO:2000374 biolink:BiologicalProcess regulation of oxygen metabolic process Any process that modulates the frequency, rate or extent of oxygen metabolic process. go.json regulation of diatomic oxygen metabolic process|regulation of oxygen metabolism http://purl.obolibrary.org/obo/GO_2000374 GO:2000375 biolink:BiologicalProcess negative regulation of oxygen metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. go.json negative regulation of diatomic oxygen metabolic process|negative regulation of oxygen metabolism http://purl.obolibrary.org/obo/GO_2000375 GO:2000376 biolink:BiologicalProcess positive regulation of oxygen metabolic process Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. go.json positive regulation of diatomic oxygen metabolic process|positive regulation of oxygen metabolism http://purl.obolibrary.org/obo/GO_2000376 GO:2000377 biolink:BiologicalProcess regulation of reactive oxygen species metabolic process Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. go.json regulation of ROS metabolic process|regulation of reactive oxygen species metabolism http://purl.obolibrary.org/obo/GO_2000377 GO:2000378 biolink:BiologicalProcess negative regulation of reactive oxygen species metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. go.json negative regulation of ROS metabolic process|negative regulation of reactive oxygen species metabolism http://purl.obolibrary.org/obo/GO_2000378 GO:2000370 biolink:BiologicalProcess positive regulation of clathrin-dependent endocytosis Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis. go.json positive regulation of clathrin coated pit-dependent endocytosis|positive regulation of clathrin-mediated endocytosis http://purl.obolibrary.org/obo/GO_2000370 GO:2000302 biolink:BiologicalProcess positive regulation of synaptic vesicle exocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis. go.json http://purl.obolibrary.org/obo/GO_2000302 GO:2000303 biolink:BiologicalProcess regulation of ceramide biosynthetic process Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. go.json regulation of ceramide anabolism|regulation of ceramide biosynthesis|regulation of ceramide formation|regulation of ceramide synthesis http://purl.obolibrary.org/obo/GO_2000303 GO:2000304 biolink:BiologicalProcess positive regulation of ceramide biosynthetic process Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process. go.json positive regulation of ceramide anabolism|positive regulation of ceramide biosynthesis|positive regulation of ceramide formation|positive regulation of ceramide synthesis http://purl.obolibrary.org/obo/GO_2000304 GO:2000305 biolink:BiologicalProcess semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance. go.json semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance|semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding|semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance|semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding http://purl.obolibrary.org/obo/GO_2000305 GO:2000306 biolink:BiologicalProcess positive regulation of photomorphogenesis Any process that activates or increases the frequency, rate or extent of photomorphogenesis. go.json positive regulation of plant development in response to light http://purl.obolibrary.org/obo/GO_2000306 GO:2000307 biolink:BiologicalProcess regulation of tumor necrosis factor (ligand) superfamily member 11 production Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. go.json regulation of RANKL production|regulation of TNFSF11 production http://purl.obolibrary.org/obo/GO_2000307 GO:2000308 biolink:BiologicalProcess negative regulation of tumor necrosis factor (ligand) superfamily member 11 production Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. go.json negative regulation of RANKL production|negative regulation of TNFSF11 production http://purl.obolibrary.org/obo/GO_2000308 GO:2000309 biolink:BiologicalProcess positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. go.json positive regulation of RANKL production|positive regulation of TNFSF11 production http://purl.obolibrary.org/obo/GO_2000309 GO:2000300 biolink:BiologicalProcess regulation of synaptic vesicle exocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. go.json http://purl.obolibrary.org/obo/GO_2000300 goslim_synapse GO:2000301 biolink:BiologicalProcess negative regulation of synaptic vesicle exocytosis Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis. go.json http://purl.obolibrary.org/obo/GO_2000301 GO:2000313 biolink:BiologicalProcess regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. go.json regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_2000313 GO:2000314 biolink:BiologicalProcess negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. go.json negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_2000314 GO:2000315 biolink:BiologicalProcess positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. go.json positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_2000315 GO:2000316 biolink:BiologicalProcess regulation of T-helper 17 type immune response Any process that modulates the frequency, rate or extent of T-helper 17 type immune response. go.json regulation of Th17 immune response http://purl.obolibrary.org/obo/GO_2000316 GO:2000317 biolink:BiologicalProcess negative regulation of T-helper 17 type immune response Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response. go.json negative regulation of Th17 immune response http://purl.obolibrary.org/obo/GO_2000317 GO:2000318 biolink:BiologicalProcess positive regulation of T-helper 17 type immune response Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response. go.json positive regulation of Th17 immune response http://purl.obolibrary.org/obo/GO_2000318 GO:2000319 biolink:BiologicalProcess regulation of T-helper 17 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation. go.json regulation of T-helper 17 cell development http://purl.obolibrary.org/obo/GO_2000319 GO:2000310 biolink:BiologicalProcess regulation of NMDA receptor activity Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. go.json regulation of N-methyl-D-aspartate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_2000310 gocheck_do_not_annotate GO:2000311 biolink:BiologicalProcess regulation of AMPA receptor activity Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. go.json regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_2000311 gocheck_do_not_annotate GO:2000312 biolink:BiologicalProcess regulation of kainate selective glutamate receptor activity Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity. go.json http://purl.obolibrary.org/obo/GO_2000312 gocheck_do_not_annotate GO:2000324 biolink:BiologicalProcess positive regulation of glucocorticoid receptor signaling pathway Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway. go.json positive regulation of glucocorticoid receptor signalling pathway http://purl.obolibrary.org/obo/GO_2000324 GO:2000325 biolink:BiologicalProcess obsolete regulation of nuclear receptor coactivator activity OBSOLETE. Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity. go.json regulation of ligand-dependent nuclear receptor transcription co-activator activity|regulation of ligand-dependent nuclear receptor transcription coactivator activity|regulation of nuclear receptor transcription coactivator activity True http://purl.obolibrary.org/obo/GO_2000325 GO:2000326 biolink:BiologicalProcess obsolete negative regulation of nuclear receptor transcription coactivator activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity. go.json negative regulation of ligand-dependent nuclear receptor transcription co-activator activity|negative regulation of ligand-dependent nuclear receptor transcription coactivator activity True http://purl.obolibrary.org/obo/GO_2000326 GO:2000327 biolink:BiologicalProcess obsolete positive regulation of nuclear receptor transcription coactivator activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity. go.json positive regulation of ligand-dependent nuclear receptor transcription co-activator activity|positive regulation of ligand-dependent nuclear receptor transcription coactivator activity True http://purl.obolibrary.org/obo/GO_2000327 GO:2000328 biolink:BiologicalProcess regulation of T-helper 17 cell lineage commitment Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment. go.json regulation of T-helper 17 cell fate commitment|regulation of Th17 cell lineage commitment|regulation of Th17 fate commitment http://purl.obolibrary.org/obo/GO_2000328 GO:2000329 biolink:BiologicalProcess negative regulation of T-helper 17 cell lineage commitment Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment. go.json negative regulation of T-helper 17 cell fate commitment|negative regulation of Th17 cell lineage commitment|negative regulation of Th17 fate commitment http://purl.obolibrary.org/obo/GO_2000329 GO:2000320 biolink:BiologicalProcess negative regulation of T-helper 17 cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation. go.json negative regulation of T-helper 17 cell development http://purl.obolibrary.org/obo/GO_2000320 GO:2000321 biolink:BiologicalProcess positive regulation of T-helper 17 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation. go.json positive regulation of T-helper 17 cell development http://purl.obolibrary.org/obo/GO_2000321 GO:2000322 biolink:BiologicalProcess regulation of glucocorticoid receptor signaling pathway Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway. go.json regulation of glucocorticoid receptor signalling pathway http://purl.obolibrary.org/obo/GO_2000322 GO:2000323 biolink:BiologicalProcess negative regulation of glucocorticoid receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway. go.json negative regulation of glucocorticoid receptor signalling pathway http://purl.obolibrary.org/obo/GO_2000323 GO:2000335 biolink:BiologicalProcess regulation of endothelial microparticle formation Any process that modulates the frequency, rate or extent of endothelial microparticle formation. go.json regulation of endothelial microparticle generation|regulation of endothelial microparticle release http://purl.obolibrary.org/obo/GO_2000335 GO:2000336 biolink:BiologicalProcess negative regulation of endothelial microparticle formation Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation. go.json negative regulation of endothelial microparticle generation|negative regulation of endothelial microparticle release http://purl.obolibrary.org/obo/GO_2000336 GO:2000337 biolink:BiologicalProcess positive regulation of endothelial microparticle formation Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation. go.json positive regulation of endothelial microparticle generation|positive regulation of endothelial microparticle release http://purl.obolibrary.org/obo/GO_2000337 GO:2000338 biolink:BiologicalProcess regulation of chemokine (C-X-C motif) ligand 1 production Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. go.json regulation of CXCL1 production|regulation of KC production|regulation of SCYB1 production|regulation of keratinocyte derived chemokine production http://purl.obolibrary.org/obo/GO_2000338 GO:2000339 biolink:BiologicalProcess negative regulation of chemokine (C-X-C motif) ligand 1 production Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. go.json negative regulation of CXCL1 production|negative regulation of KC production|negative regulation of SCYB1 production|negative regulation of keratinocyte derived chemokine production http://purl.obolibrary.org/obo/GO_2000339 GO:2000330 biolink:BiologicalProcess positive regulation of T-helper 17 cell lineage commitment Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment. go.json positive regulation of T-helper 17 cell fate commitment|positive regulation of Th17 cell lineage commitment|positive regulation of Th17 fate commitment http://purl.obolibrary.org/obo/GO_2000330 GO:2000331 biolink:BiologicalProcess regulation of terminal button organization Any process that modulates the frequency, rate or extent of terminal button organization. go.json regulation of bouton organization|regulation of presynaptic bouton organization|regulation of synaptic bouton organization|regulation of terminal bouton organization|regulation of terminal button organisation http://purl.obolibrary.org/obo/GO_2000331 GO:2000332 biolink:BiologicalProcess regulation of blood microparticle formation Any process that modulates the frequency, rate or extent of blood microparticle formation. go.json regulation of microparticle generation|regulation of microparticle release http://purl.obolibrary.org/obo/GO_2000332 GO:2000333 biolink:BiologicalProcess negative regulation of blood microparticle formation Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation. go.json negative regulation of microparticle generation|negative regulation of microparticle release http://purl.obolibrary.org/obo/GO_2000333 GO:2000334 biolink:BiologicalProcess positive regulation of blood microparticle formation Any process that activates or increases the frequency, rate or extent of blood microparticle formation. go.json positive regulation of microparticle generation|positive regulation of microparticle release http://purl.obolibrary.org/obo/GO_2000334 GO:0016587 biolink:CellularComponent Isw1 complex A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure. go.json http://purl.obolibrary.org/obo/GO_0016587 GO:0016588 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016588 GO:0016589 biolink:CellularComponent NURF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters. go.json nucleosome remodeling factor complex http://purl.obolibrary.org/obo/GO_0016589 GO:0016583 biolink:BiologicalProcess obsolete nucleosome modeling OBSOLETE. (Was not defined before being made obsolete). go.json nucleosome modeling True http://purl.obolibrary.org/obo/GO_0016583 GO:0016584 biolink:BiologicalProcess obsolete nucleosome positioning OBSOLETE. Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another. go.json nucleosome spacing True http://purl.obolibrary.org/obo/GO_0016584 GO:0016585 biolink:CellularComponent obsolete chromatin remodeling complex OBSOLETE. Any complex that mediates dynamic changes in eukaryotic chromatin. go.json chromatin remodeling complex|chromatin remodelling complex|nucleosome remodeling complex True http://purl.obolibrary.org/obo/GO_0016585 GO:0016586 biolink:CellularComponent RSC-type complex A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. go.json PBAF complex|Polybromo- and BAF containing complex|SWI/SNF complex B http://purl.obolibrary.org/obo/GO_0016586 GO:0016580 biolink:CellularComponent obsolete Sin3 complex OBSOLETE. A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. go.json True http://purl.obolibrary.org/obo/GO_0016580 GO:0016581 biolink:CellularComponent NuRD complex An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. go.json Mi-2 complex|NRD complex|nucleosome remodeling and histone deacetylation complex http://purl.obolibrary.org/obo/GO_0016581 GO:0016582 biolink:BiologicalProcess obsolete non-covalent chromatin modification OBSOLETE. The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups. go.json True http://purl.obolibrary.org/obo/GO_0016582 GO:0016598 biolink:BiologicalProcess protein arginylation The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. go.json protein amino acid arginylation http://purl.obolibrary.org/obo/GO_0016598 gocheck_do_not_annotate GO:0016599 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016599 GO:0016594 biolink:MolecularActivity glycine binding Binding to glycine, aminoethanoic acid. go.json Gly binding|aminoacetic acid binding|aminoethanoic acid binding http://purl.obolibrary.org/obo/GO_0016594 GO:0016595 biolink:MolecularActivity glutamate binding Binding to glutamate, the anion of 2-aminopentanedioic acid. go.json glutamic acid binding http://purl.obolibrary.org/obo/GO_0016595 GO:0016596 biolink:MolecularActivity thienylcyclohexylpiperidine binding Binding to thienylcyclohexylpiperidine. go.json TCP binding http://purl.obolibrary.org/obo/GO_0016596 GO:0016597 biolink:MolecularActivity amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents. go.json http://purl.obolibrary.org/obo/GO_0016597 goslim_metagenomics|goslim_pir GO:0016590 biolink:CellularComponent ACF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair. go.json ATP-utilizing chromatin assembly and remodeling factor complex http://purl.obolibrary.org/obo/GO_0016590 GO:0016591 biolink:CellularComponent RNA polymerase II, holoenzyme A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters. go.json DNA-directed RNA polymerase II, holoenzyme http://purl.obolibrary.org/obo/GO_0016591 goslim_pir GO:0016592 biolink:CellularComponent mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Wikipedia:Mediator_(coactivator) go.json CDK8-containing TRAP/mediator complex|L mediator complex|Srb-mediator complex|TRAP complex http://purl.obolibrary.org/obo/GO_0016592 GO:0016593 biolink:CellularComponent Cdc73/Paf1 complex A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. go.json Paf1 complex|Paf1p complex http://purl.obolibrary.org/obo/GO_0016593 GO:0016569 biolink:BiologicalProcess obsolete covalent chromatin modification OBSOLETE. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. go.json chromatin modification True http://purl.obolibrary.org/obo/GO_0016569 GO:0016565 biolink:MolecularActivity obsolete general transcriptional repressor activity OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set. go.json general transcriptional repressor activity True http://purl.obolibrary.org/obo/GO_0016565 GO:0016566 biolink:MolecularActivity obsolete specific transcriptional repressor activity OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes. go.json specific transcriptional repressor activity True http://purl.obolibrary.org/obo/GO_0016566 GO:0016567 biolink:BiologicalProcess protein ubiquitination The process in which one or more ubiquitin groups are added to a protein. go.json protein ubiquitinylation|protein ubiquitylation http://purl.obolibrary.org/obo/GO_0016567 GO:0016568 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016568 GO:0016561 biolink:BiologicalProcess protein import into peroxisome matrix, translocation The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. go.json peroxisome matrix protein import, translocation|peroxisome receptor translocation|protein translocation during peroxisome matrix protein import|protein translocation during protein import into peroxisome matrix|protein translocation during protein transport into peroxisome matrix|protein transport into peroxisome matrix, translocation http://purl.obolibrary.org/obo/GO_0016561 GO:0016562 biolink:BiologicalProcess protein import into peroxisome matrix, receptor recycling The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol. go.json PTS receptor recycling|peroxisome matrix protein import, receptor recycling|peroxisome receptor recycling|protein transport into peroxisome matrix, receptor recycling|receptor recycling during peroxisome matrix protein import|receptor recycling during protein import into peroxisome matrix|receptor recycling during protein transport into peroxisome matrix http://purl.obolibrary.org/obo/GO_0016562 GO:0016563 biolink:MolecularActivity obsolete transcription activator activity OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription. go.json transcription activating factor|transcription activator activity|transcriptional activator activity True http://purl.obolibrary.org/obo/GO_0016563 GO:0016564 biolink:MolecularActivity obsolete transcription repressor activity OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription. go.json negative transcriptional regulator activity|transcription repressor activity|transcriptional repressor activity True http://purl.obolibrary.org/obo/GO_0016564 GO:0016560 biolink:BiologicalProcess protein import into peroxisome matrix, docking The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane. go.json peroxisome matrix protein import, docking|peroxisome receptor docking|protein docking during peroxisome matrix protein import|protein docking during protein import into peroxisome matrix|protein docking during protein transport into peroxisome matrix|protein transport into peroxisome matrix, docking http://purl.obolibrary.org/obo/GO_0016560 GO:0016576 biolink:BiologicalProcess obsolete histone dephosphorylation OBSOLETE. The modification of histones by removal of phosphate groups. go.json True http://purl.obolibrary.org/obo/GO_0016576 GO:0016577 biolink:BiologicalProcess histone demethylation The modification of histones by removal of methyl groups. go.json http://purl.obolibrary.org/obo/GO_0016577 gocheck_do_not_annotate GO:0016578 biolink:BiologicalProcess histone deubiquitination The modification of histones by removal of ubiquitin groups. go.json histone deubiquitinylation|histone deubiquitylation http://purl.obolibrary.org/obo/GO_0016578 GO:0016579 biolink:BiologicalProcess protein deubiquitination The removal of one or more ubiquitin groups from a protein. go.json deubiquitination|protein deubiquitinylation|protein deubiquitylation http://purl.obolibrary.org/obo/GO_0016579 gocheck_do_not_annotate GO:0016572 biolink:BiologicalProcess obsolete histone phosphorylation OBSOLETE. The modification of histones by addition of phosphate groups. go.json True http://purl.obolibrary.org/obo/GO_0016572 GO:0016573 biolink:BiologicalProcess histone acetylation The modification of a histone by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0016573 gocheck_do_not_annotate GO:0016574 biolink:BiologicalProcess histone ubiquitination The modification of histones by addition of ubiquitin groups. go.json histone ubiquitinylation|histone ubiquitylation http://purl.obolibrary.org/obo/GO_0016574 gocheck_do_not_annotate GO:0016575 biolink:BiologicalProcess histone deacetylation The modification of histones by removal of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0016575 gocheck_do_not_annotate GO:0016570 biolink:BiologicalProcess histone modification The covalent alteration of one or more amino acid residues within a histone protein. Wikipedia:Histone#Histone_modifications_in_chromatin_regulation go.json http://purl.obolibrary.org/obo/GO_0016570 gocheck_do_not_annotate|goslim_yeast GO:0016571 biolink:BiologicalProcess histone methylation The modification of histones by addition of methyl groups. Wikipedia:Histone_methylation go.json http://purl.obolibrary.org/obo/GO_0016571 gocheck_do_not_annotate GO:2000382 biolink:BiologicalProcess positive regulation of mesoderm development Any process that activates or increases the frequency, rate or extent of mesoderm development. go.json http://purl.obolibrary.org/obo/GO_2000382 GO:0016547 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016547 GO:0016548 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016548 GO:2000383 biolink:BiologicalProcess regulation of ectoderm development Any process that modulates the frequency, rate or extent of ectoderm development. go.json http://purl.obolibrary.org/obo/GO_2000383 GO:2000384 biolink:BiologicalProcess negative regulation of ectoderm development Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. go.json http://purl.obolibrary.org/obo/GO_2000384 GO:0016549 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016549 GO:2000385 biolink:BiologicalProcess positive regulation of ectoderm development Any process that activates or increases the frequency, rate or extent of ectoderm development. go.json http://purl.obolibrary.org/obo/GO_2000385 GO:0016543 biolink:BiologicalProcess male courtship behavior, orientation prior to leg tapping and wing vibration The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster. go.json male courtship behavior, orientation|male courtship behaviour, orientation|male courtship behaviour, orientation prior to leg tapping and wing vibration http://purl.obolibrary.org/obo/GO_0016543 GO:2000386 biolink:BiologicalProcess positive regulation of ovarian follicle development Any process that activates or increases the frequency, rate or extent of ovarian follicle development. go.json positive regulation of follicular phase http://purl.obolibrary.org/obo/GO_2000386 GO:0016544 biolink:BiologicalProcess male courtship behavior, tapping to detect pheromone The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster. go.json male courtship behavior, tapping|male courtship behaviour, tapping|male courtship behaviour, tapping to detect pheromone http://purl.obolibrary.org/obo/GO_0016544 GO:2000387 biolink:BiologicalProcess regulation of antral ovarian follicle growth Any process that modulates the frequency, rate or extent of antral ovarian follicle growth. go.json http://purl.obolibrary.org/obo/GO_2000387 GO:0016545 biolink:BiologicalProcess male courtship behavior, veined wing vibration The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster. go.json male courtship behavior, wing vibration|male courtship behaviour, veined wing vibration|male courtship behaviour, wing vibration http://purl.obolibrary.org/obo/GO_0016545 GO:2000388 biolink:BiologicalProcess positive regulation of antral ovarian follicle growth Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth. go.json http://purl.obolibrary.org/obo/GO_2000388 GO:0016546 biolink:BiologicalProcess male courtship behavior, proboscis-mediated licking The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster. go.json male courtship behavior, licking|male courtship behaviour, licking|male courtship behaviour, proboscis-mediated licking http://purl.obolibrary.org/obo/GO_0016546 GO:2000389 biolink:BiologicalProcess regulation of neutrophil extravasation Any process that modulates the frequency, rate or extent of neutrophil extravasation. go.json http://purl.obolibrary.org/obo/GO_2000389 GO:0016540 biolink:BiologicalProcess protein autoprocessing Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. go.json http://purl.obolibrary.org/obo/GO_0016540 goslim_chembl GO:0016541 biolink:MolecularActivity obsolete intein OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity. go.json intein True http://purl.obolibrary.org/obo/GO_0016541 GO:0016542 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016542 GO:2000380 biolink:BiologicalProcess regulation of mesoderm development Any process that modulates the frequency, rate or extent of mesoderm development. go.json http://purl.obolibrary.org/obo/GO_2000380 GO:2000381 biolink:BiologicalProcess negative regulation of mesoderm development Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. go.json http://purl.obolibrary.org/obo/GO_2000381 GO:2000393 biolink:BiologicalProcess negative regulation of lamellipodium morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis. go.json negative regulation of lamellipodium organization http://purl.obolibrary.org/obo/GO_2000393 GO:0016558 biolink:BiologicalProcess protein import into peroxisome matrix The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. go.json peroxisome matrix protein import|protein transport to peroxisome matrix http://purl.obolibrary.org/obo/GO_0016558 GO:0016559 biolink:BiologicalProcess peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. go.json peroxisome division|peroxisome proliferation http://purl.obolibrary.org/obo/GO_0016559 GO:2000394 biolink:BiologicalProcess positive regulation of lamellipodium morphogenesis Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis. go.json positive regulation of lamellipodium organization http://purl.obolibrary.org/obo/GO_2000394 GO:2000395 biolink:BiologicalProcess regulation of ubiquitin-dependent endocytosis Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis. go.json regulation of ubiquitin-mediated endocytosis http://purl.obolibrary.org/obo/GO_2000395 GO:2000396 biolink:BiologicalProcess negative regulation of ubiquitin-dependent endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis. go.json negative regulation of ubiquitin-mediated endocytosis http://purl.obolibrary.org/obo/GO_2000396 GO:2000397 biolink:BiologicalProcess positive regulation of ubiquitin-dependent endocytosis Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis. go.json positive regulation of ubiquitin-mediated endocytosis http://purl.obolibrary.org/obo/GO_2000397 GO:0016554 biolink:BiologicalProcess cytidine to uridine editing The conversion of a cytosine residue to uridine in an RNA molecule by deamination. go.json http://purl.obolibrary.org/obo/GO_0016554 GO:2000398 biolink:BiologicalProcess regulation of thymocyte aggregation Any process that modulates the frequency, rate or extent of thymocyte aggregation. go.json regulation of T cell precursor aggregation|regulation of immature T cell aggregation|regulation of immature T-cell aggregation|regulation of immature T-lymphocyte aggregation|regulation of thymic lymphocyte aggregation http://purl.obolibrary.org/obo/GO_2000398 GO:0016555 biolink:BiologicalProcess uridine to cytidine editing The conversion of a uridine residue to cytosine in an RNA molecule by amination. go.json http://purl.obolibrary.org/obo/GO_0016555 GO:2000399 biolink:BiologicalProcess negative regulation of thymocyte aggregation Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation. go.json negative regulation of T cell precursor aggregation|negative regulation of immature T cell aggregation|negative regulation of immature T-cell aggregation|negative regulation of immature T-lymphocyte aggregation|negative regulation of thymic lymphocyte aggregation http://purl.obolibrary.org/obo/GO_2000399 GO:0016556 biolink:BiologicalProcess mRNA modification The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. go.json mRNA editing http://purl.obolibrary.org/obo/GO_0016556 GO:0016557 biolink:BiologicalProcess peroxisome membrane biogenesis The process in which a peroxisome membrane is synthesized, aggregates, and bonds together. go.json http://purl.obolibrary.org/obo/GO_0016557 GO:0016550 biolink:BiologicalProcess obsolete insertion or deletion editing OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription. go.json insertion or deletion editing|insertion/deletion editing True http://purl.obolibrary.org/obo/GO_0016550 GO:0016551 biolink:BiologicalProcess obsolete posttranscriptional insertion or deletion editing OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription. go.json posttranscriptional insertion or deletion editing|posttranscriptional insertion/deletion editing True http://purl.obolibrary.org/obo/GO_0016551 GO:0016552 biolink:BiologicalProcess obsolete cotranscriptional insertion or deletion editing OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription. go.json cotranscriptional insertion or deletion editing|cotranscriptional insertion/deletion editing True http://purl.obolibrary.org/obo/GO_0016552 GO:0016553 biolink:BiologicalProcess base conversion or substitution editing Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s). go.json base conversion/substitution editing http://purl.obolibrary.org/obo/GO_0016553 GO:2000390 biolink:BiologicalProcess negative regulation of neutrophil extravasation Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation. go.json http://purl.obolibrary.org/obo/GO_2000390 GO:2000391 biolink:BiologicalProcess positive regulation of neutrophil extravasation Any process that activates or increases the frequency, rate or extent of neutrophil extravasation. go.json http://purl.obolibrary.org/obo/GO_2000391 GO:2000392 biolink:BiologicalProcess regulation of lamellipodium morphogenesis Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis. go.json regulation of lamellipodium organization http://purl.obolibrary.org/obo/GO_2000392 GO:0016529 biolink:CellularComponent sarcoplasmic reticulum A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum go.json http://purl.obolibrary.org/obo/GO_0016529 GO:0016525 biolink:BiologicalProcess negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. go.json down regulation of angiogenesis|down-regulation of angiogenesis|downregulation of angiogenesis|inhibition of angiogenesis http://purl.obolibrary.org/obo/GO_0016525 GO:0016526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016526 GO:0016527 biolink:MolecularActivity obsolete brain-specific angiogenesis inhibitor activity OBSOLETE. (Was not defined before being made obsolete). go.json brain-specific angiogenesis inhibitor activity True http://purl.obolibrary.org/obo/GO_0016527 GO:0016528 biolink:CellularComponent sarcoplasm The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. Wikipedia:Sarcoplasm go.json http://purl.obolibrary.org/obo/GO_0016528 GO:0016521 biolink:MolecularActivity pituitary adenylate cyclase activating polypeptide activity The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. go.json pituitary adenylyl cyclase activating polypeptide activity http://purl.obolibrary.org/obo/GO_0016521 GO:0016522 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016522 GO:0016523 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016523 GO:0016524 biolink:MolecularActivity latrotoxin receptor activity Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json latrophilin http://purl.obolibrary.org/obo/GO_0016524 GO:0016520 biolink:MolecularActivity growth hormone-releasing hormone receptor activity Combining with growth hormone-releasing hormone to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0016520 GO:0016536 biolink:MolecularActivity obsolete cyclin-dependent protein kinase 5 activator regulator activity OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator. go.json cyclin-dependent protein kinase 5 activator regulator activity|cyclin-dependent protein kinase 5 activator, intrinsic regulator activity True http://purl.obolibrary.org/obo/GO_0016536 GO:0016537 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016537 GO:0016538 biolink:MolecularActivity cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. Reactome:R-HSA-3215385 go.json G1/S-specific cyclin|G2/M-specific cyclin|cyclin|cyclin-dependent protein kinase regulator activity|cyclin-dependent protein kinase, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0016538 GO:0016539 biolink:BiologicalProcess intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. go.json intein http://purl.obolibrary.org/obo/GO_0016539 GO:0016532 biolink:MolecularActivity superoxide dismutase copper chaperone activity A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. go.json http://purl.obolibrary.org/obo/GO_0016532 GO:0016533 biolink:CellularComponent protein kinase 5 complex A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent. go.json cyclin-dependent protein kinase 5 holoenzyme complex http://purl.obolibrary.org/obo/GO_0016533 GO:0016534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016534 GO:0016535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016535 GO:0016530 biolink:MolecularActivity metallochaperone activity Binding to and delivering metal ions to a target protein. go.json http://purl.obolibrary.org/obo/GO_0016530 goslim_pir GO:0016531 biolink:MolecularActivity copper chaperone activity Directly binding to and delivering copper ions to a target protein. go.json http://purl.obolibrary.org/obo/GO_0016531 GO:0075049 biolink:BiologicalProcess obsolete modulation of symbiont cell wall strengthening involved in entry into host OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation of symbiont cell wall strengthening during entry into host True http://purl.obolibrary.org/obo/GO_0075049 GO:0099016 biolink:BiologicalProcess evasion by virus of DNA end degradation A process by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases. VZ:3963 go.json DNA end degradation evasion by virus http://purl.obolibrary.org/obo/GO_0099016 GO:0099017 biolink:BiologicalProcess maintenance of protein localization at cell tip Any process in which localization of a protein is maintained at the cell tip. go.json maintenance of protein location at cell tip http://purl.obolibrary.org/obo/GO_0099017 GO:0099014 biolink:BiologicalProcess neuronal dense core vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. go.json http://purl.obolibrary.org/obo/GO_0099014 GO:0099015 biolink:BiologicalProcess degradation of host chromosome by virus The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis. VZ:3947 go.json http://purl.obolibrary.org/obo/GO_0099015 GO:0099012 biolink:CellularComponent neuronal dense core vesicle membrane The lipid bilayer surrounding a neuronal dense core vesicle. go.json http://purl.obolibrary.org/obo/GO_0099012 goslim_synapse GO:0099013 biolink:CellularComponent neuronal dense core vesicle lumen The volume enclosed by a neuronal dense core vesicle membrane. go.json http://purl.obolibrary.org/obo/GO_0099013 goslim_synapse GO:0099010 biolink:BiologicalProcess modification of postsynaptic structure Any process that modifies the structure of a postsynapse. go.json synapse remodelling http://purl.obolibrary.org/obo/GO_0099010 goslim_synapse GO:0099011 biolink:BiologicalProcess neuronal dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels. go.json http://purl.obolibrary.org/obo/GO_0099011 GO:1905250 biolink:BiologicalProcess obsolete positive regulation of memory OBSOLETE. Any process that activates or increases the frequency, rate or extent of memory. go.json enhancement of memory True http://purl.obolibrary.org/obo/GO_1905250 GO:1905251 biolink:BiologicalProcess epidermal growth factor receptor signaling pathway involved in heart process Any epidermal growth factor receptor signaling pathway that is involved in heart process. go.json EGF receptor signaling pathway involved in cardiac process|EGF receptor signaling pathway involved in heart process|EGF receptor signalling pathway involved in cardiac process|EGF receptor signalling pathway involved in heart process|EGFR signaling pathway involved in cardiac process|EGFR signaling pathway involved in heart process|ERBB1 signaling pathway involved in cardiac process|ERBB1 signaling pathway involved in heart process|epidermal growth factor receptor signaling pathway involved in cardiac process|epidermal growth factor receptor signalling pathway involved in cardiac process|epidermal growth factor receptor signalling pathway involved in heart process|receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_1905251 GO:1905252 biolink:BiologicalProcess obsolete regulation of epidermal growth factor receptor signaling pathway involved in heart process OBSOLETE. Any regulation of epidermal growth factor receptor signaling pathway that is involved in heart process. go.json regulation of EGF receptor signaling pathway involved in cardiac process|regulation of EGF receptor signaling pathway involved in heart process|regulation of EGF receptor signalling pathway involved in cardiac process|regulation of EGF receptor signalling pathway involved in heart process|regulation of EGFR signaling pathway involved in cardiac process|regulation of EGFR signaling pathway involved in heart process|regulation of epidermal growth factor receptor signaling pathway involved in cardiac process True http://purl.obolibrary.org/obo/GO_1905252 GO:1905253 biolink:BiologicalProcess obsolete negative regulation of epidermal growth factor receptor signaling pathway involved in heart process OBSOLETE. Any negative regulation of epidermal growth factor receptor signaling pathway that is involved in heart process. go.json down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|down regulation of epidermal growth factor receptor signaling pathway involved in heart process|down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|down-regulation of epidermal growth factor receptor signaling pathway involved in heart process|downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|downregulation of epidermal growth factor receptor signaling pathway involved in heart process|inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process|inhibition of epidermal growth factor receptor signaling pathway involved in heart process|negative regulation of EGF receptor signaling pathway involved in cardiac process|negative regulation of EGF receptor signaling pathway involved in heart process|negative regulation of EGF receptor signalling pathway involved in cardiac process|negative regulation of EGF receptor signalling pathway involved in heart process|negative regulation of EGFR signaling pathway involved in cardiac process|negative regulation of EGFR signaling pathway involved in heart process|negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process True http://purl.obolibrary.org/obo/GO_1905253 GO:1905254 biolink:BiologicalProcess obsolete positive regulation of epidermal growth factor receptor signaling pathway involved in heart process OBSOLETE. Any positive regulation of epidermal growth factor receptor signaling pathway that is involved in heart process. go.json activation of epidermal growth factor receptor signaling pathway involved in cardiac process|activation of epidermal growth factor receptor signaling pathway involved in heart process|positive regulation of EGF receptor signaling pathway involved in cardiac process|positive regulation of EGF receptor signaling pathway involved in heart process|positive regulation of EGF receptor signalling pathway involved in cardiac process|positive regulation of EGF receptor signalling pathway involved in heart process|positive regulation of EGFR signaling pathway involved in cardiac process|positive regulation of EGFR signaling pathway involved in heart process|positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|stimulation of epidermal growth factor receptor signaling pathway involved in cardiac process|stimulation of epidermal growth factor receptor signaling pathway involved in heart process|up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signaling pathway involved in heart process|up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|upregulation of epidermal growth factor receptor signaling pathway involved in heart process True http://purl.obolibrary.org/obo/GO_1905254 GO:1905255 biolink:BiologicalProcess regulation of RNA binding transcription factor activity Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity. go.json regulation of transcription factor activity http://purl.obolibrary.org/obo/GO_1905255 gocheck_do_not_annotate GO:1905256 biolink:BiologicalProcess negative regulation of RNA binding transcription factor activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding transcription factor activity. go.json down regulation of RNA binding transcription factor activity|down-regulation of RNA binding transcription factor activity|downregulation of RNA binding transcription factor activity|inhibition of RNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_1905256 gocheck_do_not_annotate GO:1905246 biolink:BiologicalProcess negative regulation of aspartic-type peptidase activity Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity. go.json down regulation of aspartic-type peptidase activity|down-regulation of aspartic-type peptidase activity|downregulation of aspartic-type peptidase activity|inhibition of aspartic-type peptidase activity|pepsin inhibitor http://purl.obolibrary.org/obo/GO_1905246 gocheck_do_not_annotate GO:1905247 biolink:BiologicalProcess positive regulation of aspartic-type peptidase activity Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity. go.json activation of aspartic-type peptidase activity|up regulation of aspartic-type peptidase activity|up-regulation of aspartic-type peptidase activity|upregulation of aspartic-type peptidase activity http://purl.obolibrary.org/obo/GO_1905247 gocheck_do_not_annotate GO:0090688 biolink:CellularComponent cleavage furrow rim The part of the cleavage furrow closest to the cell surface. go.json http://purl.obolibrary.org/obo/GO_0090688 GO:1905248 biolink:BiologicalProcess obsolete regulation of memory OBSOLETE. Any process that modulates the frequency, rate or extent of memory. go.json modulation of memory True http://purl.obolibrary.org/obo/GO_1905248 GO:0090689 biolink:CellularComponent cleavage furrow leading edge The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring. go.json http://purl.obolibrary.org/obo/GO_0090689 GO:1905249 biolink:BiologicalProcess obsolete negative regulation of memory OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of memory. go.json inhibition of memory|suppression of memory True http://purl.obolibrary.org/obo/GO_1905249 GO:0051070 biolink:BiologicalProcess galactomannan biosynthetic process The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. go.json galactomannan anabolism|galactomannan biosynthesis|galactomannan formation|galactomannan synthesis http://purl.obolibrary.org/obo/GO_0051070 GO:0051071 biolink:BiologicalProcess 4,6-pyruvylated galactose residue metabolic process The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. go.json 4,6-pyruvylated galactose residue metabolism|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism|PvGal metabolic process|PvGal metabolism http://purl.obolibrary.org/obo/GO_0051071 GO:0075040 biolink:BiologicalProcess obsolete regulation of establishment of turgor in appressorium OBSOLETE. Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium. go.json regulation of turgor formation in appressorium True http://purl.obolibrary.org/obo/GO_0075040 GO:0090682 biolink:MolecularActivity GPCR bitter taste receptor activity A G protein-coupled receptor activity that is responsible for the sense of bitter taste. go.json G protein-coupled receptor bitter taste receptor activity|G-protein coupled receptor bitter taste receptor activity http://purl.obolibrary.org/obo/GO_0090682 GO:0051074 biolink:MolecularActivity obsolete protein tetramerization activity OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. go.json protein tetramerization activity True http://purl.obolibrary.org/obo/GO_0051074 GO:0075041 biolink:BiologicalProcess obsolete positive regulation of establishment of turgor in appressorium OBSOLETE. Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium. go.json True http://purl.obolibrary.org/obo/GO_0075041 GO:0090683 biolink:MolecularActivity GPCR sweet taste receptor activity A G protein-coupled receptor activity that is responsible for the sense of sweet taste. go.json G-protein coupled receptor sweet taste receptor activity http://purl.obolibrary.org/obo/GO_0090683 GO:0051075 biolink:MolecularActivity S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. EC:2.4.99.17|RHEA:32155 go.json S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity http://purl.obolibrary.org/obo/GO_0051075 GO:0075042 biolink:BiologicalProcess obsolete negative regulation of establishment of turgor in appressorium OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium. go.json True http://purl.obolibrary.org/obo/GO_0075042 GO:0051072 biolink:BiologicalProcess 4,6-pyruvylated galactose residue biosynthetic process The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. go.json 4,6-pyruvylated galactose residue anabolism|4,6-pyruvylated galactose residue biosynthesis|4,6-pyruvylated galactose residue formation|4,6-pyruvylated galactose residue synthesis|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process|PvGal biosynthesis|PvGal biosynthetic process http://purl.obolibrary.org/obo/GO_0051072 GO:0090680 biolink:BiologicalProcess viral release via disruption of host outer membrane The dissemination of mature viral particles from a host cell via the destabilization of the cell outer membrane. go.json disruption by virus of host outer membrane http://purl.obolibrary.org/obo/GO_0090680 GO:0075043 biolink:BiologicalProcess melanization of appressorium wall The process in which melanin is produced in the appressorium of the symbiont. Melanization of the appressorium increases turgor pressure in the appressorium. go.json maintenance of turgor in appressorium by melanization|melanization of appressorium to maintain turgor pressure http://purl.obolibrary.org/obo/GO_0075043 GO:0051073 biolink:MolecularActivity adenosylcobinamide-GDP ribazoletransferase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin. EC:2.7.8.26|MetaCyc:COBALAMINSYN-RXN|RHEA:16049 go.json CobS|adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity|cobalamin (5'-phosphate) synthase activity|cobalamin synthase activity|cobalamin-5'-phosphate synthase activity http://purl.obolibrary.org/obo/GO_0051073 GO:0090681 biolink:MolecularActivity GPCR taste receptor activity A G protein-coupled receptor activity that is responsible for the sense of taste. go.json G-protein coupled taste receptor activity|G-protein-coupled taste receptor activity http://purl.obolibrary.org/obo/GO_0090681 GO:0075044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075044 GO:0090686 biolink:MolecularActivity glycine betaine-activated nonselective monoatomic cation channel activity Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts. go.json glycine betaine-activated nonselective monovalent cation channel activity http://purl.obolibrary.org/obo/GO_0090686 GO:0051078 biolink:BiologicalProcess meiotic nuclear membrane disassembly The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. go.json meiotic nuclear envelope breakdown|meiotic nuclear envelope catabolism|meiotic nuclear envelope degradation|meiotic nuclear envelope disassembly http://purl.obolibrary.org/obo/GO_0051078 GO:0075045 biolink:BiologicalProcess regulation of formation by symbiont of haustorium for nutrient acquisition from host Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075045 GO:0051079 biolink:BiologicalProcess meiosis I nuclear membrane disassembly The controlled breakdown of the nuclear membranes during the first division of meiosis. go.json meiosis I nuclear envelope breakdown|meiosis I nuclear envelope catabolism|meiosis I nuclear envelope degradation|meiosis I nuclear envelope disassembly http://purl.obolibrary.org/obo/GO_0051079 GO:0090687 biolink:BiologicalProcess activation of meiosis I spindle assembly checkpoint Any process that starts the inactive process of a meiosis I cell cycle spindle assembly checkpoint. go.json http://purl.obolibrary.org/obo/GO_0090687 GO:0075046 biolink:BiologicalProcess positive regulation of formation by symbiont of haustorium for nutrient acquisition from host Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075046 GO:0075047 biolink:BiologicalProcess negative regulation of formation by symbiont of haustorium for nutrient acquisition from host Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075047 GO:0090684 biolink:MolecularActivity contact chemoreceptor activity A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception. go.json contact chemosensation receptor activity http://purl.obolibrary.org/obo/GO_0090684 GO:0051076 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051076 GO:0099018 biolink:BiologicalProcess evasion by virus of host restriction-modification system Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction. VZ:3966 go.json restriction-modification system evasion by virus http://purl.obolibrary.org/obo/GO_0099018 GO:0099019 biolink:BiologicalProcess maintenance of protein localization at growing cell tip Any process in which localization of a protein is maintained at the growing cell tip. go.json maintenance of protein location at growing cell tip http://purl.obolibrary.org/obo/GO_0099019 GO:0075048 biolink:BiologicalProcess obsolete cell wall strengthening in symbiont involved in entry into host OBSOLETE. A process in which the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json cell wall strengthening in symbiont during entry into host|cell wall thickening in symbiont during entry into host|symbiont cell wall strengthening during entry into host True http://purl.obolibrary.org/obo/GO_0075048 GO:0090685 biolink:BiologicalProcess RNA localization to nucleus A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. go.json RNA localisation to nucleus http://purl.obolibrary.org/obo/GO_0090685 GO:0051077 biolink:CellularComponent secondary cell septum Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum. go.json secondary septum http://purl.obolibrary.org/obo/GO_0051077 GO:0099027 biolink:CellularComponent obsolete anchored component of presynaptic endocytic zone membrane OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099027 GO:0075038 biolink:BiologicalProcess obsolete negative regulation of appressorium maturation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation. go.json negative regulation of appressorium maturation on or near host|negative regulation of maturation of appressorium on or near host True http://purl.obolibrary.org/obo/GO_0075038 GO:0075039 biolink:BiologicalProcess establishment of turgor in appressorium The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json establishment of turgor in symbiont appressorium on or near host|formation of turgor in appressorium|generation of turgor in appressorium http://purl.obolibrary.org/obo/GO_0075039 GO:0099028 biolink:CellularComponent obsolete anchored component of postynaptic endocytic zone membrane OBSOLETE. The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099028 GO:0099025 biolink:CellularComponent obsolete anchored component of postsynaptic membrane OBSOLETE. The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099025 GO:0099026 biolink:CellularComponent obsolete anchored component of presynaptic membrane OBSOLETE. The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json anchored component of presynaptic plasma membrane True http://purl.obolibrary.org/obo/GO_0099026 GO:0099023 biolink:CellularComponent vesicle tethering complex Any protein complex that plays a role in vesicle tethering. go.json http://purl.obolibrary.org/obo/GO_0099023 GO:0090690 biolink:CellularComponent obsolete heteroreceptor complex OBSOLETE. A receptor complex that consists of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger. The formation of the higher level complex initiates a change in cell function. go.json True http://purl.obolibrary.org/obo/GO_0090690 GO:0099024 biolink:BiologicalProcess plasma membrane invagination An infolding of the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0099024 GO:0099021 biolink:CellularComponent cortical endoplasmic reticulum lumen The volume enclosed by the membranes of the cortical endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0099021 GO:0099022 biolink:BiologicalProcess vesicle tethering The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion. go.json http://purl.obolibrary.org/obo/GO_0099022 GO:1905260 biolink:BiologicalProcess positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress. go.json activation of intrinsic apoptotic signaling pathway in response to nitrosative stress|activation of nitrosative stress-induced apoptosis|activation of nitrosative stress-induced intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|positive regulation of nitrosative stress-induced apoptosis|up regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|up regulation of nitrosative stress-induced apoptosis|up regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|up-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|up-regulation of nitrosative stress-induced apoptosis|up-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|upregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|upregulation of nitrosative stress-induced apoptosis|upregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_1905260 GO:0099020 biolink:CellularComponent perinuclear endoplasmic reticulum lumen The volume enclosed by the membranes of the perinuclear endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0099020 GO:1905261 biolink:BiologicalProcess regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. go.json http://purl.obolibrary.org/obo/GO_1905261 GO:1905262 biolink:BiologicalProcess negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. go.json down regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|downregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|inhibition of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination http://purl.obolibrary.org/obo/GO_1905262 GO:1905263 biolink:BiologicalProcess positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. go.json activation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|up regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|up-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|upregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination http://purl.obolibrary.org/obo/GO_1905263 GO:1905264 biolink:BiologicalProcess blasticidin S metabolic process The chemical reactions and pathways involving blasticidin S. go.json blasticidin S metabolism http://purl.obolibrary.org/obo/GO_1905264 GO:1905265 biolink:BiologicalProcess blasticidin S catabolic process The chemical reactions and pathways resulting in the breakdown of blasticidin S. go.json blasticidin S breakdown|blasticidin S catabolism|blasticidin S degradation http://purl.obolibrary.org/obo/GO_1905265 GO:1905266 biolink:BiologicalProcess blasticidin S biosynthetic process The chemical reactions and pathways resulting in the formation of blasticidin S. go.json blasticidin S anabolism|blasticidin S biosynthesis|blasticidin S formation|blasticidin S synthesis http://purl.obolibrary.org/obo/GO_1905266 GO:1905267 biolink:BiologicalProcess obsolete endonucleolytic cleavage involved in tRNA processing OBSOLETE. Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing. go.json RNA phosphodiester bond hydrolysis, endonucleolytic involved in tRNA maturation True http://purl.obolibrary.org/obo/GO_1905267 GO:1905257 biolink:BiologicalProcess positive regulation of RNA binding transcription factor activity Any process that activates or increases the frequency, rate or extent of RNA binding transcription factor activity. go.json activation of RNA binding transcription factor activity|up regulation of RNA binding transcription factor activity|up-regulation of RNA binding transcription factor activity|upregulation of RNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_1905257 gocheck_do_not_annotate GO:1905258 biolink:BiologicalProcess regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress. go.json regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|regulation of nitrosative stress-induced apoptosis http://purl.obolibrary.org/obo/GO_1905258 GO:1905259 biolink:BiologicalProcess negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress. go.json down regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|down regulation of nitrosative stress-induced apoptosis|down regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|down-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|down-regulation of nitrosative stress-induced apoptosis|down-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|downregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|downregulation of nitrosative stress-induced apoptosis|downregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|inhibition of intrinsic apoptotic signaling pathway in response to nitrosative stress|inhibition of nitrosative stress-induced apoptosis|inhibition of nitrosative stress-induced intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress|negative regulation of nitrosative stress-induced apoptosis http://purl.obolibrary.org/obo/GO_1905259 GO:0090699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090699 GO:0051081 biolink:BiologicalProcess nuclear membrane disassembly The controlled breakdown of the nuclear membranes, for example during cellular division. go.json nuclear envelope breakdown|nuclear envelope catabolism|nuclear envelope degradation|nuclear envelope disassembly http://purl.obolibrary.org/obo/GO_0051081 GO:0051082 biolink:MolecularActivity unfolded protein binding Binding to an unfolded protein. Reactome:R-HSA-9683772|Reactome:R-HSA-9694337 go.json chaperone activity http://purl.obolibrary.org/obo/GO_0051082 goslim_chembl|goslim_drosophila|goslim_yeast GO:0051080 biolink:BiologicalProcess meiosis II nuclear membrane disassembly The controlled breakdown of the nuclear membranes during the second division of meiosis. go.json meiosis II nuclear envelope breakdown|meiosis II nuclear envelope catabolism|meiosis II nuclear envelope degradation|meiosis II nuclear envelope disassembly http://purl.obolibrary.org/obo/GO_0051080 GO:0051085 biolink:BiologicalProcess chaperone cofactor-dependent protein refolding The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. go.json chaperone co-factor-dependent protein folding|chaperone co-factor-dependent protein refolding|chaperone cofactor-dependent 'de novo' protein folding|chaperone cofactor-dependent protein folding|chaperone mediated protein folding requiring cofactor http://purl.obolibrary.org/obo/GO_0051085 GO:0075030 biolink:BiologicalProcess modulation of formation of symbiont germ tube hook structure for appressorium development Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation. go.json modulation of germ tube tip of symbiont on or near the exterior of host|modulation of symbiont germ tube hook structure formation on or near host|regulation of formation of symbiont germ tube hook structure on or near host http://purl.obolibrary.org/obo/GO_0075030 GO:0090693 biolink:BiologicalProcess plant organ senescence A plant organ developmental process during which a plant dismantles cellular components to reclaim the cellular building blocks and nutrients that have been deposited in the plant organs during growth. go.json http://purl.obolibrary.org/obo/GO_0090693 GO:0075031 biolink:BiologicalProcess positive regulation of formation of symbiont germ tube hook structure for appressorium development Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation. go.json positive regulation of formation of symbiont germ tube hook structure on or near host|positive regulation of germ tube tip of symbiont on or near the exterior of host|positive regulation of symbiont germ tube hook structure formation on or near host http://purl.obolibrary.org/obo/GO_0075031 GO:0051086 biolink:BiologicalProcess chaperone mediated protein folding independent of cofactor The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release. go.json chaperone cofactor-independent protein folding http://purl.obolibrary.org/obo/GO_0051086 GO:0090694 biolink:CellularComponent Scc2-Scc4 cohesin loading complex A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA. go.json Mis4-Ssl3 cohesin loading complex http://purl.obolibrary.org/obo/GO_0090694 GO:0075032 biolink:BiologicalProcess negative regulation of formation of symbiont germ tube hook structure for appressorium development Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation. go.json negative regulation of formation of symbiont germ tube hook structure on or near host|negative regulation of germ tube tip of symbiont on or near the exterior of host|negative regulation of symbiont germ tube hook structure formation on or near host http://purl.obolibrary.org/obo/GO_0075032 GO:0051083 biolink:BiologicalProcess 'de novo' cotranslational protein folding The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. go.json 'de novo' co-translational protein folding|multidomain protein assembly|nascent polypeptide association http://purl.obolibrary.org/obo/GO_0051083 GO:0090691 biolink:BiologicalProcess formation of plant organ boundary The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. go.json http://purl.obolibrary.org/obo/GO_0090691 GO:0090692 biolink:CellularComponent mitochondrial membrane scission site The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission. go.json http://purl.obolibrary.org/obo/GO_0090692 GO:0051084 biolink:BiologicalProcess 'de novo' post-translational protein folding The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. go.json 'de novo' posttranslational protein folding http://purl.obolibrary.org/obo/GO_0051084 GO:0075033 biolink:BiologicalProcess obsolete appressorium septum formation OBSOLETE. The process in which a symbiont partition is formed to separate the appressorium from the germination tube, occurring during appressorium formation. go.json septum formation during appressorium formation on or near host|septum formation involved in appressorium formation|septum formation involved in appressorium formation on or near host True http://purl.obolibrary.org/obo/GO_0075033 GO:0090697 biolink:BiologicalProcess post-embryonic plant organ morphogenesis Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json http://purl.obolibrary.org/obo/GO_0090697 GO:0075034 biolink:BiologicalProcess obsolete nuclear division involved in appressorium formation OBSOLETE. The process in which nuclear division occurs within a symbiont spore that contributes to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json nuclear division during appressorium formation on or near host|nuclear division involved in appressorium formation on or near host True http://purl.obolibrary.org/obo/GO_0075034 GO:0051089 biolink:BiologicalProcess constitutive protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. go.json http://purl.obolibrary.org/obo/GO_0051089 GO:0075035 biolink:BiologicalProcess appressorium maturation The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json appressorium maturation on or near host|maturation of appressorium on or near host|maturation of symbiont appressorium on or near host http://purl.obolibrary.org/obo/GO_0075035 GO:0090698 biolink:BiologicalProcess post-embryonic plant morphogenesis The process, occurring after plant embryonic development, by which anatomical structures are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0090698 GO:0090695 biolink:CellularComponent Wpl/Pds5 cohesin loading/unloading complex A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA. go.json http://purl.obolibrary.org/obo/GO_0090695 GO:0075036 biolink:BiologicalProcess obsolete regulation of appressorium maturation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont appressorium maturation. go.json regulation of appressorium maturation on or near host|regulation of maturation of appressorium on or near host True http://purl.obolibrary.org/obo/GO_0075036 GO:0051087 biolink:MolecularActivity protein-folding chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. go.json chaperone binding|chaperone protein binding|co-chaperone activity|co-chaperonin activity http://purl.obolibrary.org/obo/GO_0051087 GO:0099029 biolink:CellularComponent obsolete anchored component of presynaptic active zone membrane OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099029 GO:0090696 biolink:BiologicalProcess post-embryonic plant organ development Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json http://purl.obolibrary.org/obo/GO_0090696 GO:0051088 biolink:BiologicalProcess obsolete PMA-inducible membrane protein ectodomain proteolysis OBSOLETE. The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist. go.json True http://purl.obolibrary.org/obo/GO_0051088 GO:0075037 biolink:BiologicalProcess obsolete positive regulation of appressorium maturation OBSOLETE. Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation. go.json positive regulation maturation of appressorium on or near host|positive regulation of appressorium maturation on or near host True http://purl.obolibrary.org/obo/GO_0075037 GO:1905270 biolink:BiologicalProcess Meynert cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a Meynert cell. go.json http://purl.obolibrary.org/obo/GO_1905270 GO:1905271 biolink:BiologicalProcess regulation of proton-transporting ATP synthase activity, rotational mechanism Any process that modulates the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. go.json regulation of H+-transporting ATP synthase activity|regulation of hydrogen ion translocating F-type ATPase activity|regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|regulation of hydrogen ion transporting two-sector ATPase activity http://purl.obolibrary.org/obo/GO_1905271 gocheck_do_not_annotate GO:1905272 biolink:BiologicalProcess negative regulation of proton-transporting ATP synthase activity, rotational mechanism Any process that stops, prevents or reduces the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. go.json down regulation of H+-transporting ATP synthase activity|down regulation of hydrogen ion translocating F-type ATPase activity|down regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|down regulation of hydrogen ion transporting two-sector ATPase activity|down regulation of proton-transporting ATP synthase activity, rotational mechanism|down-regulation of H+-transporting ATP synthase activity|down-regulation of hydrogen ion translocating F-type ATPase activity|down-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|down-regulation of hydrogen ion transporting two-sector ATPase activity|down-regulation of proton-transporting ATP synthase activity, rotational mechanism|downregulation of H+-transporting ATP synthase activity|downregulation of hydrogen ion translocating F-type ATPase activity|downregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|downregulation of hydrogen ion transporting two-sector ATPase activity|downregulation of proton-transporting ATP synthase activity, rotational mechanism|inhibition of H+-transporting ATP synthase activity|inhibition of hydrogen ion translocating F-type ATPase activity|inhibition of hydrogen ion transporting ATP synthase activity, rotational mechanism|inhibition of hydrogen ion transporting two-sector ATPase activity|inhibition of proton-transporting ATP synthase activity, rotational mechanism|negative regulation of H+-transporting ATP synthase activity|negative regulation of hydrogen ion translocating F-type ATPase activity|negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|negative regulation of hydrogen ion transporting two-sector ATPase activity http://purl.obolibrary.org/obo/GO_1905272 gocheck_do_not_annotate GO:1905273 biolink:BiologicalProcess positive regulation of proton-transporting ATP synthase activity, rotational mechanism Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. go.json activation of H+-transporting ATP synthase activity|activation of hydrogen ion translocating F-type ATPase activity|activation of hydrogen ion transporting ATP synthase activity, rotational mechanism|activation of hydrogen ion transporting two-sector ATPase activity|activation of proton-transporting ATP synthase activity, rotational mechanism|positive regulation of H+-transporting ATP synthase activity|positive regulation of hydrogen ion translocating F-type ATPase activity|positive regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|positive regulation of hydrogen ion transporting two-sector ATPase activity|up regulation of H+-transporting ATP synthase activity|up regulation of hydrogen ion translocating F-type ATPase activity|up regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|up regulation of hydrogen ion transporting two-sector ATPase activity|up regulation of proton-transporting ATP synthase activity, rotational mechanism|up-regulation of H+-transporting ATP synthase activity|up-regulation of hydrogen ion translocating F-type ATPase activity|up-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|up-regulation of hydrogen ion transporting two-sector ATPase activity|up-regulation of proton-transporting ATP synthase activity, rotational mechanism|upregulation of H+-transporting ATP synthase activity|upregulation of hydrogen ion translocating F-type ATPase activity|upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|upregulation of hydrogen ion transporting two-sector ATPase activity|upregulation of proton-transporting ATP synthase activity, rotational mechanism http://purl.obolibrary.org/obo/GO_1905273 gocheck_do_not_annotate GO:1905274 biolink:BiologicalProcess regulation of modification of postsynaptic actin cytoskeleton Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton. go.json regulation of postsynaptic actin cytoskeleton remodelling http://purl.obolibrary.org/obo/GO_1905274 goslim_synapse GO:1905275 biolink:BiologicalProcess Rohon-Beard neuron differentiation The process in which a relatively unspecialized cell acquires the specialized features of a Rohon-Beard neuron. go.json http://purl.obolibrary.org/obo/GO_1905275 GO:1905276 biolink:BiologicalProcess regulation of epithelial tube formation Any process that modulates the frequency, rate or extent of epithelial tube formation. go.json http://purl.obolibrary.org/obo/GO_1905276 GO:1905277 biolink:BiologicalProcess negative regulation of epithelial tube formation Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. go.json down regulation of epithelial tube formation|down-regulation of epithelial tube formation|downregulation of epithelial tube formation|inhibition of epithelial tube formation http://purl.obolibrary.org/obo/GO_1905277 GO:1905278 biolink:BiologicalProcess positive regulation of epithelial tube formation Any process that activates or increases the frequency, rate or extent of epithelial tube formation. go.json activation of epithelial tube formation|up regulation of epithelial tube formation|up-regulation of epithelial tube formation|upregulation of epithelial tube formation http://purl.obolibrary.org/obo/GO_1905278 GO:1905268 biolink:BiologicalProcess negative regulation of chromatin organization Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. go.json down regulation of chromatin assembly or disassembly|down regulation of chromatin organisation|down regulation of chromatin organization|down regulation of establishment or maintenance of chromatin architecture|down-regulation of chromatin assembly or disassembly|down-regulation of chromatin organisation|down-regulation of chromatin organization|down-regulation of establishment or maintenance of chromatin architecture|downregulation of chromatin assembly or disassembly|downregulation of chromatin organisation|downregulation of chromatin organization|downregulation of establishment or maintenance of chromatin architecture|inhibition of chromatin assembly or disassembly|inhibition of chromatin organisation|inhibition of chromatin organization|inhibition of establishment or maintenance of chromatin architecture|negative regulation of chromatin assembly or disassembly|negative regulation of chromatin assembly/disassembly|negative regulation of chromatin modification|negative regulation of chromatin organisation|negative regulation of establishment or maintenance of chromatin architecture http://purl.obolibrary.org/obo/GO_1905268 GO:0090668 biolink:BiologicalProcess endothelial cell chemotaxis to vascular endothelial growth factor The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF). go.json http://purl.obolibrary.org/obo/GO_0090668 GO:1905269 biolink:BiologicalProcess positive regulation of chromatin organization Any process that activates or increases the frequency, rate or extent of chromatin organization. go.json activation of chromatin assembly or disassembly|activation of chromatin organisation|activation of chromatin organization|activation of establishment or maintenance of chromatin architecture|positive regulation of chromatin assembly or disassembly|positive regulation of chromatin assembly/disassembly|positive regulation of chromatin modification|positive regulation of chromatin organisation|positive regulation of establishment or maintenance of chromatin architecture|stimulation of chromatin assembly or disassembly|up regulation of chromatin assembly or disassembly|up regulation of chromatin organisation|up regulation of chromatin organization|up regulation of establishment or maintenance of chromatin architecture|up-regulation of chromatin assembly or disassembly|up-regulation of chromatin organisation|up-regulation of chromatin organization|up-regulation of establishment or maintenance of chromatin architecture|upregulation of chromatin assembly or disassembly|upregulation of chromatin organisation|upregulation of chromatin organization|upregulation of establishment or maintenance of chromatin architecture http://purl.obolibrary.org/obo/GO_1905269 GO:0090669 biolink:BiologicalProcess telomerase RNA stabilization Prevention of degradation of telomerase RNA (TERC) molecules. go.json TERC stabilization http://purl.obolibrary.org/obo/GO_0090669 GO:0090666 biolink:BiologicalProcess scaRNA localization to Cajal body A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body. go.json http://purl.obolibrary.org/obo/GO_0090666 GO:0090667 biolink:BiologicalProcess cell chemotaxis to vascular endothelial growth factor The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF). go.json http://purl.obolibrary.org/obo/GO_0090667 GO:0051092 biolink:BiologicalProcess positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. go.json NF-kappaB activation|activation of NF-kappaB|activation of NF-kappaB transcription factor http://purl.obolibrary.org/obo/GO_0051092 gocheck_do_not_annotate GO:0051093 biolink:BiologicalProcess negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). go.json down regulation of developmental process|down-regulation of developmental process|downregulation of developmental process|inhibition of developmental process http://purl.obolibrary.org/obo/GO_0051093 GO:0075060 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075060 GO:0051090 biolink:BiologicalProcess regulation of DNA-binding transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. go.json regulation of DNA binding transcription factor activity|regulation of androgen receptor activity|regulation of sequence-specific DNA binding transcription factor activity|regulation of thyroid hormone receptor activity|regulation of transcription factor activity http://purl.obolibrary.org/obo/GO_0051090 gocheck_do_not_annotate GO:0075061 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075061 GO:0051091 biolink:BiologicalProcess positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. go.json activation of transcription factor activity|positive regulation of DNA binding transcription factor activity|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of thyroid hormone receptor activity|positive regulation of transcription factor activity|stimulation of transcription factor activity|up regulation of transcription factor activity|up-regulation of transcription factor activity|upregulation of transcription factor activity http://purl.obolibrary.org/obo/GO_0051091 gocheck_do_not_annotate GO:0075062 biolink:BiologicalProcess obsolete regulation of invasive hypha growth OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont invasive hypha formation in host|regulation of symbiont invasive hypha formation within host True http://purl.obolibrary.org/obo/GO_0075062 GO:0090660 biolink:BiologicalProcess cerebrospinal fluid circulation The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional. go.json CSF circulation|CSF flow|cerebrospinal fluid flow http://purl.obolibrary.org/obo/GO_0090660 GO:0075063 biolink:BiologicalProcess obsolete positive regulation of invasive hypha growth OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont invasive hypha formation in host|positive regulation of symbiont invasive hypha formation within host True http://purl.obolibrary.org/obo/GO_0075063 GO:0051096 biolink:BiologicalProcess positive regulation of helicase activity Any process that activates or increases the activity of a helicase. go.json activation of helicase activity|stimulation of helicase activity|up regulation of helicase activity|up-regulation of helicase activity|upregulation of helicase activity http://purl.obolibrary.org/obo/GO_0051096 gocheck_do_not_annotate GO:0051097 biolink:BiologicalProcess negative regulation of helicase activity Any process that stops or reduces the activity of a helicase. go.json down regulation of helicase activity|down-regulation of helicase activity|downregulation of helicase activity|inhibition of helicase activity http://purl.obolibrary.org/obo/GO_0051097 gocheck_do_not_annotate GO:0090661 biolink:CellularComponent box H/ACA telomerase RNP complex A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell. go.json http://purl.obolibrary.org/obo/GO_0090661 GO:0075064 biolink:BiologicalProcess obsolete negative regulation invasive hypha growth OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont invasive hypha formation in host|negative regulation of symbiont invasive hypha formation within host True http://purl.obolibrary.org/obo/GO_0075064 GO:0051094 biolink:BiologicalProcess positive regulation of developmental process Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). go.json activation of developmental process|stimulation of developmental process|up regulation of developmental process|up-regulation of developmental process|upregulation of developmental process http://purl.obolibrary.org/obo/GO_0051094 GO:0075065 biolink:BiologicalProcess obsolete growth or development of symbiont in host cell OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of symbiont in host cell True http://purl.obolibrary.org/obo/GO_0075065 GO:0051095 biolink:BiologicalProcess regulation of helicase activity Any process that modulates the frequency, rate or extent of helicase activity. go.json http://purl.obolibrary.org/obo/GO_0051095 gocheck_do_not_annotate GO:0075066 biolink:BiologicalProcess obsolete growth or development of symbiont in host organelle OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of symbiont in host organelle True http://purl.obolibrary.org/obo/GO_0075066 GO:0075067 biolink:BiologicalProcess obsolete growth or development of symbiont in host intercellular space OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of symbiont in host intercellular space True http://purl.obolibrary.org/obo/GO_0075067 GO:0090664 biolink:BiologicalProcess response to high population density Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area. go.json response to crowding http://purl.obolibrary.org/obo/GO_0090664 GO:0090665 biolink:CellularComponent glycoprotein complex A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. go.json http://purl.obolibrary.org/obo/GO_0090665 GO:0075068 biolink:BiologicalProcess obsolete growth or development of symbiont in host vascular tissue OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of symbiont in host vascular tissue True http://purl.obolibrary.org/obo/GO_0075068 GO:0075069 biolink:BiologicalProcess adhesion of symbiont infection cushion to host The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont infection cushion to host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075069 GO:0051098 biolink:BiologicalProcess regulation of binding Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. go.json http://purl.obolibrary.org/obo/GO_0051098 gocheck_do_not_annotate GO:0090662 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090662 GO:0090663 biolink:BiologicalProcess galanin-activated signaling pathway The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor. go.json galanin signaling pathway|galanin signalling pathway|galanin-activated signalling pathway http://purl.obolibrary.org/obo/GO_0090663 GO:0051099 biolink:BiologicalProcess positive regulation of binding Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. go.json activation of binding|stimulation of binding|up regulation of binding|up-regulation of binding|upregulation of binding http://purl.obolibrary.org/obo/GO_0051099 gocheck_do_not_annotate GO:0099005 biolink:CellularComponent extrinsic component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0099005 goslim_synapse GO:0099006 biolink:BiologicalProcess viral entry via permeabilization of endosomal membrane The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen. VZ:985 go.json viral penetration via permeabilization of host membrane http://purl.obolibrary.org/obo/GO_0099006 GO:0099003 biolink:BiologicalProcess vesicle-mediated transport in synapse Any vesicle-mediated transport that occurs in a synapse. go.json http://purl.obolibrary.org/obo/GO_0099003 goslim_synapse GO:0099004 biolink:BiologicalProcess calmodulin dependent kinase signaling pathway Any signal transduction pathway involving calmodulin dependent kinase activity. go.json CAMK signaling pathway http://purl.obolibrary.org/obo/GO_0099004 GO:0099001 biolink:BiologicalProcess viral genome ejection through host cell envelope, long flexible tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. VZ:3952 go.json viral long flexible tail ejection system http://purl.obolibrary.org/obo/GO_0099001 GO:0099002 biolink:BiologicalProcess viral genome ejection through host cell envelope, short tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. VZ:3954 go.json viral short tail ejection system http://purl.obolibrary.org/obo/GO_0099002 GO:1905280 biolink:BiologicalProcess negative regulation of retrograde transport, endosome to Golgi Any process that stops, prevents or reduces the frequency, rate or extent of retrograde transport, endosome to Golgi. go.json down regulation of retrograde (endosome to Golgi) transport|down regulation of retrograde transport, endosome to Golgi|down-regulation of retrograde (endosome to Golgi) transport|down-regulation of retrograde transport, endosome to Golgi|downregulation of retrograde (endosome to Golgi) transport|downregulation of retrograde transport, endosome to Golgi|inhibition of retrograde (endosome to Golgi) transport|inhibition of retrograde transport, endosome to Golgi|negative regulation of retrograde (endosome to Golgi) transport http://purl.obolibrary.org/obo/GO_1905280 GO:0099000 biolink:BiologicalProcess viral genome ejection through host cell envelope, contractile tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. VZ:3950 go.json viral contractile tail ejection system http://purl.obolibrary.org/obo/GO_0099000 GO:1905281 biolink:BiologicalProcess positive regulation of retrograde transport, endosome to Golgi Any process that activates or increases the frequency, rate or extent of retrograde transport, endosome to Golgi. go.json activation of retrograde (endosome to Golgi) transport|activation of retrograde transport, endosome to Golgi|positive regulation of retrograde (endosome to Golgi) transport|up regulation of retrograde (endosome to Golgi) transport|up regulation of retrograde transport, endosome to Golgi|up-regulation of retrograde (endosome to Golgi) transport|up-regulation of retrograde transport, endosome to Golgi|upregulation of retrograde (endosome to Golgi) transport|upregulation of retrograde transport, endosome to Golgi http://purl.obolibrary.org/obo/GO_1905281 GO:1905282 biolink:BiologicalProcess regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. go.json regulation of EGF receptor signaling pathway involved in cardiac process|regulation of EGF receptor signaling pathway involved in heart process|regulation of EGF receptor signalling pathway involved in cardiac process|regulation of EGF receptor signalling pathway involved in heart process|regulation of EGFR signaling pathway involved in cardiac process|regulation of EGFR signaling pathway involved in heart process|regulation of ERBB1 signaling pathway involved in cardiac process|regulation of ERBB1 signaling pathway involved in heart process|regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|regulation of epidermal growth factor receptor signalling pathway involved in heart process|regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_1905282 GO:1905283 biolink:BiologicalProcess negative regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. go.json down regulation of EGF receptor signaling pathway involved in cardiac process|down regulation of EGF receptor signaling pathway involved in heart process|down regulation of EGF receptor signalling pathway involved in cardiac process|down regulation of EGF receptor signalling pathway involved in heart process|down regulation of EGFR signaling pathway involved in cardiac process|down regulation of EGFR signaling pathway involved in heart process|down regulation of ERBB1 signaling pathway involved in cardiac process|down regulation of ERBB1 signaling pathway involved in heart process|down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|down regulation of epidermal growth factor receptor signaling pathway involved in heart process|down regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|down regulation of epidermal growth factor receptor signalling pathway involved in heart process|down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|down-regulation of EGF receptor signaling pathway involved in cardiac process|down-regulation of EGF receptor signaling pathway involved in heart process|down-regulation of EGF receptor signalling pathway involved in cardiac process|down-regulation of EGF receptor signalling pathway involved in heart process|down-regulation of EGFR signaling pathway involved in cardiac process|down-regulation of EGFR signaling pathway involved in heart process|down-regulation of ERBB1 signaling pathway involved in cardiac process|down-regulation of ERBB1 signaling pathway involved in heart process|down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|down-regulation of epidermal growth factor receptor signaling pathway involved in heart process|down-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|down-regulation of epidermal growth factor receptor signalling pathway involved in heart process|down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|downregulation of EGF receptor signaling pathway involved in cardiac process|downregulation of EGF receptor signaling pathway involved in heart process|downregulation of EGF receptor signalling pathway involved in cardiac process|downregulation of EGF receptor signalling pathway involved in heart process|downregulation of EGFR signaling pathway involved in cardiac process|downregulation of EGFR signaling pathway involved in heart process|downregulation of ERBB1 signaling pathway involved in cardiac process|downregulation of ERBB1 signaling pathway involved in heart process|downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|downregulation of epidermal growth factor receptor signaling pathway involved in heart process|downregulation of epidermal growth factor receptor signalling pathway involved in cardiac process|downregulation of epidermal growth factor receptor signalling pathway involved in heart process|downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|inhibition of EGF receptor signaling pathway involved in cardiac process|inhibition of EGF receptor signaling pathway involved in heart process|inhibition of EGF receptor signalling pathway involved in cardiac process|inhibition of EGF receptor signalling pathway involved in heart process|inhibition of EGFR signaling pathway involved in cardiac process|inhibition of EGFR signaling pathway involved in heart process|inhibition of ERBB1 signaling pathway involved in cardiac process|inhibition of ERBB1 signaling pathway involved in heart process|inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process|inhibition of epidermal growth factor receptor signaling pathway involved in heart process|inhibition of epidermal growth factor receptor signalling pathway involved in cardiac process|inhibition of epidermal growth factor receptor signalling pathway involved in heart process|inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|negative regulation of EGF receptor signaling pathway involved in cardiac process|negative regulation of EGF receptor signaling pathway involved in heart process|negative regulation of EGF receptor signalling pathway involved in cardiac process|negative regulation of EGF receptor signalling pathway involved in heart process|negative regulation of EGFR signaling pathway involved in cardiac process|negative regulation of EGFR signaling pathway involved in heart process|negative regulation of ERBB1 signaling pathway involved in cardiac process|negative regulation of ERBB1 signaling pathway involved in heart process|negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|negative regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|negative regulation of epidermal growth factor receptor signalling pathway involved in heart process|negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_1905283 GO:1905284 biolink:BiologicalProcess positive regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. go.json activation of EGF receptor signaling pathway involved in cardiac process|activation of EGF receptor signaling pathway involved in heart process|activation of EGF receptor signalling pathway involved in cardiac process|activation of EGF receptor signalling pathway involved in heart process|activation of EGFR signaling pathway involved in cardiac process|activation of EGFR signaling pathway involved in heart process|activation of ERBB1 signaling pathway involved in cardiac process|activation of ERBB1 signaling pathway involved in heart process|activation of epidermal growth factor receptor signaling pathway involved in cardiac process|activation of epidermal growth factor receptor signaling pathway involved in heart process|activation of epidermal growth factor receptor signalling pathway involved in cardiac process|activation of epidermal growth factor receptor signalling pathway involved in heart process|activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|positive regulation of EGF receptor signaling pathway involved in cardiac process|positive regulation of EGF receptor signaling pathway involved in heart process|positive regulation of EGF receptor signalling pathway involved in cardiac process|positive regulation of EGF receptor signalling pathway involved in heart process|positive regulation of EGFR signaling pathway involved in cardiac process|positive regulation of EGFR signaling pathway involved in heart process|positive regulation of ERBB1 signaling pathway involved in cardiac process|positive regulation of ERBB1 signaling pathway involved in heart process|positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|positive regulation of epidermal growth factor receptor signalling pathway involved in heart process|positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up regulation of EGF receptor signaling pathway involved in cardiac process|up regulation of EGF receptor signaling pathway involved in heart process|up regulation of EGF receptor signalling pathway involved in cardiac process|up regulation of EGF receptor signalling pathway involved in heart process|up regulation of EGFR signaling pathway involved in cardiac process|up regulation of EGFR signaling pathway involved in heart process|up regulation of ERBB1 signaling pathway involved in cardiac process|up regulation of ERBB1 signaling pathway involved in heart process|up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signaling pathway involved in heart process|up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signalling pathway involved in heart process|up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up-regulation of EGF receptor signaling pathway involved in cardiac process|up-regulation of EGF receptor signaling pathway involved in heart process|up-regulation of EGF receptor signalling pathway involved in cardiac process|up-regulation of EGF receptor signalling pathway involved in heart process|up-regulation of EGFR signaling pathway involved in cardiac process|up-regulation of EGFR signaling pathway involved in heart process|up-regulation of ERBB1 signaling pathway involved in cardiac process|up-regulation of ERBB1 signaling pathway involved in heart process|up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signaling pathway involved in heart process|up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signalling pathway involved in heart process|up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|upregulation of EGF receptor signaling pathway involved in cardiac process|upregulation of EGF receptor signaling pathway involved in heart process|upregulation of EGF receptor signalling pathway involved in cardiac process|upregulation of EGF receptor signalling pathway involved in heart process|upregulation of EGFR signaling pathway involved in cardiac process|upregulation of EGFR signaling pathway involved in heart process|upregulation of ERBB1 signaling pathway involved in cardiac process|upregulation of ERBB1 signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|upregulation of epidermal growth factor receptor signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process|upregulation of epidermal growth factor receptor signalling pathway involved in heart process|upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_1905284 GO:1905285 biolink:BiologicalProcess fibrous ring of heart morphogenesis The developmental process by which a fibrous ring of heart is generated and organized. go.json Lower's ring morphogenesis|annulus fibrosus cordis morphogenesis|anulus fibrosus cordis morphogenesis|anulus fibrosus of heart morphogenesis|aortic annulus morphogenesis|atrioventricular ring morphogenesis|coronary tendon morphogenesis http://purl.obolibrary.org/obo/GO_1905285 GO:1905286 biolink:CellularComponent serine-type peptidase complex A protein complex which is capable of serine-type peptidase activity. go.json Factor VII - TF complex http://purl.obolibrary.org/obo/GO_1905286 GO:1905287 biolink:BiologicalProcess positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation Any positive regulation of G2/M transition of mitotic cell cycle that is involved in cellular response to nitrogen starvation. go.json positive regulation of mitotic entry involved in cellular response to nitrogen starvation http://purl.obolibrary.org/obo/GO_1905287 GO:1905288 biolink:BiologicalProcess vascular associated smooth muscle cell apoptotic process Any apoptotic process in a vascular associated smooth muscle cell. go.json VSMC apoptosis|VSMC apoptotic process|vascular associated smooth muscle cell apoptosis|vascular smooth muscle cell apoptosis|vascular smooth muscle cell apoptotic process http://purl.obolibrary.org/obo/GO_1905288 GO:1905289 biolink:BiologicalProcess regulation of CAMKK-AMPK signaling cascade Any process that modulates the frequency, rate or extent of CAMKK-AMPK signaling cascade. go.json regulation of stress-activated AMP-activated protein kinase signaling cascade http://purl.obolibrary.org/obo/GO_1905289 GO:1905279 biolink:BiologicalProcess regulation of retrograde transport, endosome to Golgi Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi. go.json regulation of retrograde (endosome to Golgi) transport http://purl.obolibrary.org/obo/GO_1905279 GO:0090679 biolink:BiologicalProcess cell differentiation involved in phenotypic switching A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. go.json http://purl.obolibrary.org/obo/GO_0090679 GO:0090677 biolink:BiologicalProcess reversible differentiation A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another. go.json http://purl.obolibrary.org/obo/GO_0090677 GO:0090678 biolink:BiologicalProcess cell dedifferentiation involved in phenotypic switching A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. go.json http://purl.obolibrary.org/obo/GO_0090678 GO:0075050 biolink:BiologicalProcess obsolete positive regulation of symbiont cell wall strengthening involved in entry into host OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont cell wall strengthening during entry into host True http://purl.obolibrary.org/obo/GO_0075050 GO:0075051 biolink:BiologicalProcess obsolete negative regulation of symbiont cell wall strengthening involved in entry into host OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont cell wall strengthening during entry into host True http://purl.obolibrary.org/obo/GO_0075051 GO:0090671 biolink:BiologicalProcess telomerase RNA localization to Cajal body A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body. go.json http://purl.obolibrary.org/obo/GO_0090671 GO:0075052 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075052 GO:0090672 biolink:BiologicalProcess telomerase RNA localization Any process in which telomerase RNA is transported to, or maintained in, a specific location. go.json http://purl.obolibrary.org/obo/GO_0090672 GO:0075053 biolink:BiologicalProcess penetration peg formation The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation of symbiont penetration peg for entry into host|initiation of symbiont penetration peg|symbiont penetration peg formation for entry into host|symbiont penetration peg initiation http://purl.obolibrary.org/obo/GO_0075053 GO:0075054 biolink:BiologicalProcess modulation of penetration peg formation Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation of symbiont penetration peg formation for entry into host|modulation of symbiont penetration peg initiation http://purl.obolibrary.org/obo/GO_0075054 GO:0075055 biolink:BiologicalProcess positive regulation of penetration peg formation Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont penetration peg formation for entry into host|positive regulation of symbiont penetration peg initiation http://purl.obolibrary.org/obo/GO_0075055 GO:0090670 biolink:BiologicalProcess RNA localization to Cajal body A process in which an RNA is transported to, or maintained in, a Cajal body. go.json http://purl.obolibrary.org/obo/GO_0090670 GO:0075056 biolink:BiologicalProcess obsolete negative regulation of penetration peg formation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont penetration peg formation for entry into host|negative regulation of symbiont penetration peg initiation True http://purl.obolibrary.org/obo/GO_0075056 GO:0090675 biolink:BiologicalProcess intermicrovillar adhesion The cell-cell adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin. go.json http://purl.obolibrary.org/obo/GO_0090675 GO:0099009 biolink:BiologicalProcess viral genome circularization The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities. VZ:3968 go.json http://purl.obolibrary.org/obo/GO_0099009 GO:0075057 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075057 GO:0090676 biolink:BiologicalProcess calcium ion transmembrane transport via low voltage-gated calcium channel A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel. go.json generation of T-type calcium current http://purl.obolibrary.org/obo/GO_0090676 GO:0090673 biolink:BiologicalProcess endothelial cell-matrix adhesion The binding of an endothelial cell to the extracellular matrix via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0090673 GO:0075058 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075058 GO:0099007 biolink:CellularComponent extrinsic component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0099007 goslim_synapse GO:0090674 biolink:BiologicalProcess endothelial cell-matrix adhesion via fibronectin The binding of an endothelial cell to the extracellular matrix via fibronectin. go.json http://purl.obolibrary.org/obo/GO_0090674 GO:0075059 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075059 GO:0099008 biolink:BiologicalProcess viral entry via permeabilization of inner membrane The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane. VZ:985 go.json viral penetration via permeabilization of host membrane http://purl.obolibrary.org/obo/GO_0099008 GO:0099058 biolink:CellularComponent obsolete integral component of postsynaptic endocytic zone membrane OBSOLETE. The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099058 GO:0099059 biolink:CellularComponent obsolete integral component of presynaptic active zone membrane OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099059 GO:0099056 biolink:CellularComponent obsolete integral component of presynaptic membrane OBSOLETE. The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral component of presynaptic plasma membrane True http://purl.obolibrary.org/obo/GO_0099056 GO:1905290 biolink:BiologicalProcess negative regulation of CAMKK-AMPK signaling cascade Any process that stops, prevents or reduces the frequency, rate or extent of CAMKK-AMPK signaling cascade. go.json down regulation of CAMKK-AMPK signaling cascade|down regulation of stress-activated AMP-activated protein kinase signaling cascade|down-regulation of CAMKK-AMPK signaling cascade|down-regulation of stress-activated AMP-activated protein kinase signaling cascade|downregulation of CAMKK-AMPK signaling cascade|downregulation of stress-activated AMP-activated protein kinase signaling cascade|inhibition of CAMKK-AMPK signaling cascade|inhibition of stress-activated AMP-activated protein kinase signaling cascade|negative regulation of stress-activated AMP-activated protein kinase signaling cascade http://purl.obolibrary.org/obo/GO_1905290 GO:0099057 biolink:CellularComponent obsolete integral component of presynaptic endocytic zone membrane OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099057 GO:0099054 biolink:BiologicalProcess presynapse assembly The aggregation, arrangement and bonding together of a set of components to form a presynapse. go.json presynapse biogenesis|presynaptic terminal assembly http://purl.obolibrary.org/obo/GO_0099054 goslim_synapse GO:1905291 biolink:BiologicalProcess positive regulation of CAMKK-AMPK signaling cascade Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade. go.json activation of CAMKK-AMPK signaling cascade|activation of stress-activated AMP-activated protein kinase signaling cascade|positive regulation of stress-activated AMP-activated protein kinase signaling cascade|up regulation of CAMKK-AMPK signaling cascade|up regulation of stress-activated AMP-activated protein kinase signaling cascade|up-regulation of CAMKK-AMPK signaling cascade|up-regulation of stress-activated AMP-activated protein kinase signaling cascade|upregulation of CAMKK-AMPK signaling cascade|upregulation of stress-activated AMP-activated protein kinase signaling cascade http://purl.obolibrary.org/obo/GO_1905291 GO:1905292 biolink:BiologicalProcess regulation of neural crest cell differentiation Any process that modulates the frequency, rate or extent of neural crest cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1905292 GO:0099055 biolink:CellularComponent obsolete integral component of postsynaptic membrane OBSOLETE. The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099055 GO:1905293 biolink:BiologicalProcess negative regulation of neural crest cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. go.json down regulation of neural crest cell differentiation|down-regulation of neural crest cell differentiation|downregulation of neural crest cell differentiation|inhibition of neural crest cell differentiation http://purl.obolibrary.org/obo/GO_1905293 GO:0099052 biolink:BiologicalProcess vesicle scission involved in clathrin-mediated endocytosis The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0099052 GO:1905294 biolink:BiologicalProcess positive regulation of neural crest cell differentiation Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. go.json activation of neural crest cell differentiation|up regulation of neural crest cell differentiation|up-regulation of neural crest cell differentiation|upregulation of neural crest cell differentiation http://purl.obolibrary.org/obo/GO_1905294 GO:0099053 biolink:CellularComponent activating signal cointegrator 1 complex A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3. go.json ASC-1 complex http://purl.obolibrary.org/obo/GO_0099053 GO:1905295 biolink:BiologicalProcess regulation of neural crest cell fate specification Any process that modulates the frequency, rate or extent of neural crest cell fate specification. go.json http://purl.obolibrary.org/obo/GO_1905295 GO:0099050 biolink:BiologicalProcess vesicle scission The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane. go.json http://purl.obolibrary.org/obo/GO_0099050 GO:0099051 biolink:BiologicalProcess vesicle scission involved in endocytosis The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0099051 GO:1905296 biolink:BiologicalProcess negative regulation of neural crest cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell fate specification. go.json down regulation of neural crest cell fate specification|down-regulation of neural crest cell fate specification|downregulation of neural crest cell fate specification|inhibition of neural crest cell fate specification http://purl.obolibrary.org/obo/GO_1905296 GO:1905297 biolink:BiologicalProcess positive regulation of neural crest cell fate specification Any process that activates or increases the frequency, rate or extent of neural crest cell fate specification. go.json activation of neural crest cell fate specification|up regulation of neural crest cell fate specification|up-regulation of neural crest cell fate specification|upregulation of neural crest cell fate specification http://purl.obolibrary.org/obo/GO_1905297 GO:1905298 biolink:BiologicalProcess regulation of intestinal epithelial cell development Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. go.json http://purl.obolibrary.org/obo/GO_1905298 GO:1905299 biolink:BiologicalProcess negative regulation of intestinal epithelial cell development Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. go.json down regulation of intestinal epithelial cell development|down-regulation of intestinal epithelial cell development|downregulation of intestinal epithelial cell development|inhibition of intestinal epithelial cell development http://purl.obolibrary.org/obo/GO_1905299 GO:0075080 biolink:BiologicalProcess obsolete negative regulation by host of symbiont receptor-mediated signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075080 GO:0075081 biolink:BiologicalProcess obsolete modulation by host of symbiont transmembrane receptor-mediated signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075081 GO:0075082 biolink:BiologicalProcess obsolete positive regulation by host of symbiont transmembrane receptor-mediated signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075082 GO:0075083 biolink:BiologicalProcess obsolete negative regulation by host of symbiont transmembrane receptor-mediated signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075083 GO:0075084 biolink:BiologicalProcess obsolete modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by host of symbiont transmembrane receptor-mediated cAMP signaling True http://purl.obolibrary.org/obo/GO_0075084 GO:0075085 biolink:BiologicalProcess obsolete positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction|positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling|promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction|stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction|upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction True http://purl.obolibrary.org/obo/GO_0075085 GO:0075086 biolink:BiologicalProcess obsolete negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction|inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction|negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling True http://purl.obolibrary.org/obo/GO_0075086 GO:0075087 biolink:BiologicalProcess obsolete modulation by host of symbiont G protein-coupled receptor signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by host of symbiont G-protein coupled receptor protein signal transduction True http://purl.obolibrary.org/obo/GO_0075087 GO:0075088 biolink:BiologicalProcess obsolete positive regulation by host of symbiont G protein-coupled receptor signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by host of symbiont G-protein coupled receptor protein signal transduction True http://purl.obolibrary.org/obo/GO_0075088 GO:0075089 biolink:BiologicalProcess obsolete negative regulation by host of symbiont G protein-coupled receptor signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by host of symbiont G-protein coupled receptor protein signal transduction True http://purl.obolibrary.org/obo/GO_0075089 GO:0099069 biolink:BiologicalProcess synaptic vesicle tethering involved in synaptic vesicle exocytosis The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion. go.json http://purl.obolibrary.org/obo/GO_0099069 GO:0099067 biolink:CellularComponent obsolete integral component of presynaptic endosome membrane OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099067 GO:0099068 biolink:BiologicalProcess postsynapse assembly The aggregation, arrangement and bonding together of a set of components to form a postsynapse. go.json postsynapse biogenesis http://purl.obolibrary.org/obo/GO_0099068 GO:0099065 biolink:CellularComponent obsolete integral component of spine apparatus membrane OBSOLETE. The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099065 GO:0099066 biolink:CellularComponent obsolete integral component of neuronal dense core vesicle membrane OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099066 GO:0099063 biolink:CellularComponent obsolete integral component of postsynaptic recycling endosome membrane OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099063 GO:0099064 biolink:CellularComponent obsolete integral component of postsynaptic endosome membrane OBSOLETE. The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099064 GO:0099061 biolink:CellularComponent obsolete integral component of postsynaptic density membrane OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099061 GO:0099062 biolink:CellularComponent obsolete integral component of postsynaptic early endosome membrane OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099062 GO:0099060 biolink:CellularComponent obsolete integral component of postsynaptic specialization membrane OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099060 GO:0075070 biolink:BiologicalProcess adhesion of symbiont hyphopodium to host The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont hyphopodium to host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075070 GO:0075071 biolink:BiologicalProcess symbiont-mediated perturbation of host autophagy Any process in which a symbiont organism modulates the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json autophagy during symbiotic interaction|autophagy involved in symbiotic interaction|modulation by symbiont of host autophagic process|modulation by symbiont of host autophagy|symbiont-mediated modulation of host autophagy http://purl.obolibrary.org/obo/GO_0075071 GO:0075072 biolink:BiologicalProcess obsolete autophagy of symbiont cells involved in interaction with host OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json autophagy of symbiont cells during interaction with host True http://purl.obolibrary.org/obo/GO_0075072 GO:0075073 biolink:BiologicalProcess obsolete autophagy of symbiont cells on or near host surface OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075073 GO:0075074 biolink:BiologicalProcess obsolete spore autophagy involved in appressorium formation on or near host OBSOLETE. The process in which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json autophagy of spores during appressorium formation on or near host|spore autophagy during appressorium formation on or near host True http://purl.obolibrary.org/obo/GO_0075074 GO:0075075 biolink:BiologicalProcess obsolete modulation by host of symbiont adenylate cyclase activity OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075075 GO:0075076 biolink:BiologicalProcess obsolete positive regulation by host of symbiont adenylate cyclase activity OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075076 GO:0075077 biolink:BiologicalProcess obsolete negative regulation by host of symbiont adenylate cyclase activity OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075077 GO:0075078 biolink:BiologicalProcess obsolete modulation by host of symbiont receptor-mediated signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075078 GO:0075079 biolink:BiologicalProcess obsolete positive regulation by host of symbiont receptor-mediated signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075079 GO:0099038 biolink:MolecularActivity ceramide floppase activity Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json ATP-dependent ceramide transporter activity|ATPase-coupled ceramide transporter activity|ceramide floppase activity (cytosolic to exoplasmic leaftlet)|ceramide-translocating ATPase activity http://purl.obolibrary.org/obo/GO_0099038 GO:0099039 biolink:BiologicalProcess sphingolipid translocation The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. go.json http://purl.obolibrary.org/obo/GO_0099039 GO:0099036 biolink:CellularComponent obsolete anchored component of neuronal dense core vesicle membrane OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099036 GO:0099037 biolink:CellularComponent obsolete anchored component of presynaptic endosome membrane OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099037 GO:0002089 biolink:BiologicalProcess lens morphogenesis in camera-type eye The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. go.json lens morphogenesis|lens morphogenesis in camera-style eye http://purl.obolibrary.org/obo/GO_0002089 GO:0099034 biolink:CellularComponent obsolete anchored component of postsynaptic endosome membrane OBSOLETE. The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099034 GO:0099035 biolink:CellularComponent obsolete anchored component of spine apparatus membrane OBSOLETE. The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099035 GO:0099032 biolink:CellularComponent obsolete anchored component of postsynaptic early endosome membrane OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099032 GO:0099033 biolink:CellularComponent obsolete anchored component of postsynaptic recycling endosome membrane OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099033 GO:0002085 biolink:BiologicalProcess inhibition of neuroepithelial cell differentiation Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. go.json negative regulation of neural plate formation|repression of premature neural plate formation http://purl.obolibrary.org/obo/GO_0002085 GO:0099030 biolink:CellularComponent obsolete anchored component of postsynaptic specialization membrane OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099030 GO:0002086 biolink:BiologicalProcess diaphragm contraction A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange. go.json http://purl.obolibrary.org/obo/GO_0002086 GO:0099031 biolink:CellularComponent obsolete anchored component of postsynaptic density membrane OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099031 GO:0002087 biolink:BiologicalProcess regulation of respiratory gaseous exchange by nervous system process A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. go.json neurological control of breathing|regulation of respiratory gaseous exchange by neurological system process http://purl.obolibrary.org/obo/GO_0002087 GO:0002088 biolink:BiologicalProcess lens development in camera-type eye The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. go.json lens development|lens development in camera-style eye http://purl.obolibrary.org/obo/GO_0002088 GO:0002081 biolink:CellularComponent outer acrosomal membrane The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction. go.json http://purl.obolibrary.org/obo/GO_0002081 GO:0002082 biolink:BiologicalProcess regulation of oxidative phosphorylation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. go.json OXPHOS http://purl.obolibrary.org/obo/GO_0002082 GO:0002083 biolink:MolecularActivity 4-hydroxybenzoate decaprenyltransferase activity Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate. EC:2.5.1.39|MetaCyc:RXN-9230|RHEA:44564|Reactome:R-HSA-2162192 go.json http://purl.obolibrary.org/obo/GO_0002083 GO:0002084 biolink:BiologicalProcess protein depalmitoylation The removal of palymitoyl groups from a lipoprotein. go.json http://purl.obolibrary.org/obo/GO_0002084 gocheck_do_not_annotate GO:0002090 biolink:BiologicalProcess regulation of receptor internalization Any process that modulates the frequency, rate or extent of receptor internalization. go.json http://purl.obolibrary.org/obo/GO_0002090 GO:0002091 biolink:BiologicalProcess negative regulation of receptor internalization Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization. go.json down regulation of receptor internalization|down-regulation of receptor internalization|downregulation of receptor internalization|inhibition of receptor internalization http://purl.obolibrary.org/obo/GO_0002091 GO:0099049 biolink:BiologicalProcess clathrin coat assembly involved in endocytosis The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation. go.json http://purl.obolibrary.org/obo/GO_0099049 GO:0099047 biolink:BiologicalProcess clearance of foreign intracellular RNA A defense process that protects an organism from invading foreign RNA. go.json http://purl.obolibrary.org/obo/GO_0099047 GO:0099048 biolink:BiologicalProcess CRISPR-cas system A defense response of that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci. go.json http://purl.obolibrary.org/obo/GO_0099048 GO:0099045 biolink:BiologicalProcess viral extrusion The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded. VZ:3951 go.json http://purl.obolibrary.org/obo/GO_0099045 GO:0099046 biolink:BiologicalProcess clearance of foreign intracellular nucleic acids A defense process that protects an organism from DNA or RNA from an invading organism. go.json http://purl.obolibrary.org/obo/GO_0099046 GO:0099043 biolink:BiologicalProcess cargo loading involved in clathrin-dependent endocytosis Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat. go.json http://purl.obolibrary.org/obo/GO_0099043 GO:0099044 biolink:BiologicalProcess vesicle tethering to endoplasmic reticulum The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion. go.json http://purl.obolibrary.org/obo/GO_0099044 GO:0099041 biolink:BiologicalProcess vesicle tethering to Golgi The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion. go.json http://purl.obolibrary.org/obo/GO_0099041 GO:0002096 biolink:CellularComponent polkadots A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals. go.json http://purl.obolibrary.org/obo/GO_0002096 GO:0099042 biolink:BiologicalProcess obsolete nucleation of clathrin-coated pit OBSOLETE. The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit. go.json True http://purl.obolibrary.org/obo/GO_0099042 GO:0002097 biolink:BiologicalProcess tRNA wobble base modification The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified. go.json http://purl.obolibrary.org/obo/GO_0002097 GO:0002098 biolink:BiologicalProcess tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. go.json http://purl.obolibrary.org/obo/GO_0002098 GO:0099040 biolink:BiologicalProcess ceramide translocation The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet. go.json http://purl.obolibrary.org/obo/GO_0099040 GO:0002099 biolink:BiologicalProcess tRNA wobble guanine modification The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified. go.json http://purl.obolibrary.org/obo/GO_0002099 GO:0002092 biolink:BiologicalProcess positive regulation of receptor internalization Any process that activates or increases the frequency, rate or extent of receptor internalization. go.json activation of receptor internalization|stimulation of receptor internalization|up regulation of receptor internalization|up-regulation of receptor internalization|upregulation of receptor internalization http://purl.obolibrary.org/obo/GO_0002092 GO:0002093 biolink:BiologicalProcess auditory receptor cell morphogenesis Any process that alters the size or shape of an auditory receptor cell. go.json hair cell morphogenesis http://purl.obolibrary.org/obo/GO_0002093 GO:0002094 biolink:MolecularActivity polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). go.json http://purl.obolibrary.org/obo/GO_0002094 GO:0002095 biolink:CellularComponent caveolar macromolecular signaling complex A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3). go.json caveolar macromolecular signalling complex http://purl.obolibrary.org/obo/GO_0002095 GO:0075090 biolink:BiologicalProcess obsolete modulation by host of symbiont signal transduction mediated by G-protein alpha subunit OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075090 GO:0075091 biolink:BiologicalProcess obsolete positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075091 GO:0075092 biolink:BiologicalProcess obsolete negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075092 GO:0075093 biolink:BiologicalProcess obsolete modulation by host of symbiont signal transduction mediated by G-protein beta subunit OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075093 GO:0075094 biolink:BiologicalProcess obsolete positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075094 GO:0075095 biolink:BiologicalProcess obsolete negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075095 GO:0075096 biolink:BiologicalProcess obsolete modulation by host of symbiont signal transduction mediated by G-protein gamma subunit OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075096 GO:0075097 biolink:BiologicalProcess obsolete positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075097 GO:0075098 biolink:BiologicalProcess obsolete negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075098 GO:0075099 biolink:BiologicalProcess obsolete modulation by host of symbiont protein kinase-mediated signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075099 GO:0090602 biolink:BiologicalProcess sieve element enucleation The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded. go.json http://purl.obolibrary.org/obo/GO_0090602 GO:0090603 biolink:BiologicalProcess sieve element differentiation The process whereby a relatively unspecialized cell acquires specialized features of a sieve element. go.json http://purl.obolibrary.org/obo/GO_0090603 GO:0090600 biolink:MolecularActivity alpha-1,3-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose. go.json http://purl.obolibrary.org/obo/GO_0090600 GO:0090601 biolink:BiologicalProcess enucleation The process in which nucleated precursor cells lose their nucleus. go.json http://purl.obolibrary.org/obo/GO_0090601 GO:0090606 biolink:BiologicalProcess single-species surface biofilm formation A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface. go.json multicellular pellicle formation http://purl.obolibrary.org/obo/GO_0090606 GO:0090607 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090607 GO:0090604 biolink:BiologicalProcess surface biofilm formation A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. go.json http://purl.obolibrary.org/obo/GO_0090604 GO:0090605 biolink:BiologicalProcess submerged biofilm formation A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription. go.json solid substrate biofilm formation http://purl.obolibrary.org/obo/GO_0090605 GO:0051005 biolink:BiologicalProcess negative regulation of lipoprotein lipase activity Any process that stops or reduces the activity of the enzyme lipoprotein lipase. go.json down regulation of lipoprotein lipase activity|down-regulation of lipoprotein lipase activity|downregulation of lipoprotein lipase activity|inhibition of lipoprotein lipase activity http://purl.obolibrary.org/obo/GO_0051005 gocheck_do_not_annotate GO:0051006 biolink:BiologicalProcess positive regulation of lipoprotein lipase activity Any process that activates or increases the activity of the enzyme lipoprotein lipase. go.json activation of lipoprotein lipase activity|stimulation of lipoprotein lipase activity|up regulation of lipoprotein lipase activity|up-regulation of lipoprotein lipase activity|upregulation of lipoprotein lipase activity http://purl.obolibrary.org/obo/GO_0051006 gocheck_do_not_annotate GO:0051003 biolink:MolecularActivity ligase activity, forming nitrogen-metal bonds, forming coordination complexes Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex. EC:6.6.1.- go.json http://purl.obolibrary.org/obo/GO_0051003 GO:0051004 biolink:BiologicalProcess regulation of lipoprotein lipase activity Any process that modulates the activity of the enzyme lipoprotein lipase. go.json http://purl.obolibrary.org/obo/GO_0051004 gocheck_do_not_annotate GO:0051009 biolink:MolecularActivity O-acetylhomoserine sulfhydrylase activity Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate. MetaCyc:ACETYLHOMOSER-CYS-RXN|RHEA:27822 go.json http://purl.obolibrary.org/obo/GO_0051009 GO:0051007 biolink:MolecularActivity squalene-hopene cyclase activity Catalysis of the reaction: squalene = hop-22(29)-ene. EC:5.4.99.17|MetaCyc:5.4.99.17-RXN|RHEA:17637 go.json squalene mutase (cyclizing)|squalene:hopene cyclase activity http://purl.obolibrary.org/obo/GO_0051007 GO:0051008 biolink:MolecularActivity Hsp27 protein binding Binding to Hsp27 proteins, a lightweight heat shock protein. go.json http://purl.obolibrary.org/obo/GO_0051008 GO:0090608 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090608 GO:0090609 biolink:BiologicalProcess single-species submerged biofilm formation A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription. go.json http://purl.obolibrary.org/obo/GO_0090609 GO:0090613 biolink:MolecularActivity 5'-deoxyadenosine deaminase activity Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3. EC:3.5.4.41|RHEA:42892 go.json http://purl.obolibrary.org/obo/GO_0090613 GO:0090614 biolink:MolecularActivity 5'-methylthioadenosine deaminase activity Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. EC:3.5.4.31|RHEA:25025 go.json http://purl.obolibrary.org/obo/GO_0090614 GO:0090611 biolink:BiologicalProcess ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination. go.json http://purl.obolibrary.org/obo/GO_0090611 GO:0090612 biolink:MolecularActivity cAMP deaminase activity Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3. EC:3.5.4.46|RHEA:22908 go.json cyclic adenosine monophosphate deaminase activity http://purl.obolibrary.org/obo/GO_0090612 GO:0090617 biolink:BiologicalProcess mitochondrial mRNA 5'-end processing Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome. go.json http://purl.obolibrary.org/obo/GO_0090617 GO:0090618 biolink:BiologicalProcess DNA clamp unloading The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates. go.json PCNA unloading http://purl.obolibrary.org/obo/GO_0090618 GO:0090615 biolink:BiologicalProcess mitochondrial mRNA processing Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs. go.json http://purl.obolibrary.org/obo/GO_0090615 GO:0090616 biolink:BiologicalProcess mitochondrial mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome. go.json http://purl.obolibrary.org/obo/GO_0090616 GO:0051001 biolink:BiologicalProcess negative regulation of nitric-oxide synthase activity Any process that stops or reduces the activity of the enzyme nitric-oxide synthase. go.json NOS inhibitor|down regulation of nitric-oxide synthase activity|down-regulation of nitric-oxide synthase activity|downregulation of nitric-oxide synthase activity|inhibition of nitric-oxide synthase activity|negative regulation of NOS activity|nitric-oxide synthase inhibitor http://purl.obolibrary.org/obo/GO_0051001 gocheck_do_not_annotate GO:0051002 biolink:MolecularActivity ligase activity, forming nitrogen-metal bonds Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.6.-.- go.json http://purl.obolibrary.org/obo/GO_0051002 GO:0090610 biolink:BiologicalProcess bundle sheath cell fate specification The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0090610 GO:0051000 biolink:BiologicalProcess positive regulation of nitric-oxide synthase activity Any process that activates or increases the activity of the enzyme nitric-oxide synthase. go.json NOS activator|activation of nitric-oxide synthase activity|nitric-oxide synthase activator|positive regulation of NOS activity|stimulation of nitric-oxide synthase activity|up regulation of nitric-oxide synthase activity|up-regulation of nitric-oxide synthase activity|upregulation of nitric-oxide synthase activity http://purl.obolibrary.org/obo/GO_0051000 gocheck_do_not_annotate GO:0051016 biolink:BiologicalProcess barbed-end actin filament capping The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. go.json barbed-end F-actin capping activity|barbed-end actin capping activity|plus-end F-actin capping activity|plus-end actin filament capping activity http://purl.obolibrary.org/obo/GO_0051016 GO:0051017 biolink:BiologicalProcess actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. go.json actin bundling activity|actin cable assembly|actin cable formation http://purl.obolibrary.org/obo/GO_0051017 GO:0051014 biolink:BiologicalProcess actin filament severing The process in which an actin filament is broken down into smaller filaments. go.json F-actin severing|actin filament severing activity|barbed-end actin capping/severing activity http://purl.obolibrary.org/obo/GO_0051014 GO:0051015 biolink:MolecularActivity actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. go.json F-actin binding|actin cross-linking activity http://purl.obolibrary.org/obo/GO_0051015 GO:0051018 biolink:MolecularActivity protein kinase A binding Binding to a protein kinase A. go.json PKA binding|protein kinase A anchoring activity http://purl.obolibrary.org/obo/GO_0051018 GO:0051019 biolink:MolecularActivity mitogen-activated protein kinase binding Binding to a mitogen-activated protein kinase. go.json MAP kinase binding|MAP-kinase anchoring activity|MAPK binding http://purl.obolibrary.org/obo/GO_0051019 GO:0051012 biolink:BiologicalProcess microtubule sliding The movement of one microtubule along another microtubule. go.json microtubule translocation http://purl.obolibrary.org/obo/GO_0051012 GO:0051013 biolink:BiologicalProcess microtubule severing The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends. go.json microtubule severing activity http://purl.obolibrary.org/obo/GO_0051013 GO:0051010 biolink:MolecularActivity microtubule plus-end binding Binding to the plus end of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0051010 GO:0051011 biolink:MolecularActivity microtubule minus-end binding Binding to the minus end of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0051011 GO:0051027 biolink:BiologicalProcess DNA transport The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051027 GO:0051028 biolink:BiologicalProcess mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051028 GO:0051025 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051025 GO:0051026 biolink:BiologicalProcess chiasma assembly The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids. go.json http://purl.obolibrary.org/obo/GO_0051026 GO:0051029 biolink:BiologicalProcess rRNA transport The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051029 GO:1905200 biolink:BiologicalProcess gibberellic acid transmembrane transport The directed movement of gibberellic acid across a membrane. go.json http://purl.obolibrary.org/obo/GO_1905200 GO:1905201 biolink:MolecularActivity gibberellin transmembrane transporter activity Enables the transfer of gibberellin from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1905201 GO:0051020 biolink:MolecularActivity GTPase binding Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP. go.json http://purl.obolibrary.org/obo/GO_0051020 GO:0051023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051023 GO:0051024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051024 GO:0051021 biolink:MolecularActivity GDP-dissociation inhibitor binding Binding to a GDP-dissociation inhibitor protein. go.json GDI binding http://purl.obolibrary.org/obo/GO_0051021 GO:0051022 biolink:MolecularActivity Rho GDP-dissociation inhibitor binding Binding to a Rho GDP-dissociation inhibitor protein. go.json Rho GDI binding http://purl.obolibrary.org/obo/GO_0051022 GO:0051038 biolink:BiologicalProcess obsolete negative regulation of transcription involved in meiotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle. go.json down regulation of transcription during meiosis|down-regulation of transcription during meiosis|downregulation of transcription during meiosis|inhibition of transcription during meiosis|meiotic repression of transcription|negative regulation of meiotic transcription|negative regulation of transcription, meiotic True http://purl.obolibrary.org/obo/GO_0051038 GO:0075005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075005 GO:0051039 biolink:BiologicalProcess obsolete positive regulation of transcription involved in meiotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle. go.json activation of transcription during meiosis|positive regulation of meiotic transcription|positive regulation of transcription, meiotic|stimulation of transcription during meiosis|up regulation of transcription during meiosis|up-regulation of transcription during meiosis|upregulation of transcription during meiosis True http://purl.obolibrary.org/obo/GO_0051039 GO:0075006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075006 GO:0075007 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075007 GO:0051036 biolink:BiologicalProcess regulation of endosome size Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. go.json endosome enlargement http://purl.obolibrary.org/obo/GO_0051036 GO:0051037 biolink:BiologicalProcess obsolete regulation of transcription involved in meiotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle. go.json meiotic regulation of transcription|regulation of transcription, meiotic True http://purl.obolibrary.org/obo/GO_0051037 GO:0075008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075008 GO:0075009 biolink:BiologicalProcess germ tube formation Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json germ tube formation on or near host http://purl.obolibrary.org/obo/GO_0075009 GO:1905210 biolink:BiologicalProcess regulation of fibroblast chemotaxis Any process that modulates the frequency, rate or extent of fibroblast chemotaxis. go.json http://purl.obolibrary.org/obo/GO_1905210 GO:1905211 biolink:BiologicalProcess negative regulation of fibroblast chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis. go.json down regulation of fibroblast chemotaxis|down-regulation of fibroblast chemotaxis|downregulation of fibroblast chemotaxis|inhibition of fibroblast chemotaxis http://purl.obolibrary.org/obo/GO_1905211 GO:1905212 biolink:BiologicalProcess positive regulation of fibroblast chemotaxis Any process that activates or increases the frequency, rate or extent of fibroblast chemotaxis. go.json activation of fibroblast chemotaxis|up regulation of fibroblast chemotaxis|up-regulation of fibroblast chemotaxis|upregulation of fibroblast chemotaxis http://purl.obolibrary.org/obo/GO_1905212 GO:1905202 biolink:CellularComponent methylcrotonoyl-CoA carboxylase complex A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity. go.json http://purl.obolibrary.org/obo/GO_1905202 GO:0090646 biolink:BiologicalProcess mitochondrial tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0090646 GO:1905203 biolink:BiologicalProcess regulation of connective tissue replacement Any process that modulates the frequency, rate or extent of connective tissue replacement. go.json http://purl.obolibrary.org/obo/GO_1905203 GO:0090647 biolink:BiologicalProcess obsolete modulation of age-related behavioral decline OBSOLETE. Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory. go.json True http://purl.obolibrary.org/obo/GO_0090647 GO:1905204 biolink:BiologicalProcess negative regulation of connective tissue replacement Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement. go.json down regulation of connective tissue replacement|down-regulation of connective tissue replacement|downregulation of connective tissue replacement|inhibition of connective tissue replacement http://purl.obolibrary.org/obo/GO_1905204 GO:0090644 biolink:BiologicalProcess age-related resistance An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR). go.json ARR|adult seedling resistance|developmental resistance|flowering-induced resistance|mature seedling resistance|ontogenic resistance|senescence-induced resistance http://purl.obolibrary.org/obo/GO_0090644 GO:1905205 biolink:BiologicalProcess positive regulation of connective tissue replacement Any process that activates or increases the frequency, rate or extent of connective tissue replacement. go.json activation of connective tissue replacement|up regulation of connective tissue replacement|up-regulation of connective tissue replacement|upregulation of connective tissue replacement http://purl.obolibrary.org/obo/GO_1905205 GO:0090645 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090645 GO:1905206 biolink:BiologicalProcess obsolete positive regulation of hydrogen peroxide-induced cell death OBSOLETE. Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide. go.json activation of cell death in response to H2O2|activation of cell death in response to hydrogen peroxide|activation of hydrogen peroxide-mediated cell death|positive regulation of cell death in response to H2O2|positive regulation of cell death in response to hydrogen peroxide|positive regulation of hydrogen peroxide-mediated cell death|up regulation of cell death in response to H2O2|up regulation of cell death in response to hydrogen peroxide|up regulation of hydrogen peroxide-mediated cell death|up-regulation of cell death in response to H2O2|up-regulation of cell death in response to hydrogen peroxide|up-regulation of hydrogen peroxide-mediated cell death|upregulation of cell death in response to H2O2|upregulation of cell death in response to hydrogen peroxide|upregulation of hydrogen peroxide-mediated cell death True http://purl.obolibrary.org/obo/GO_1905206 GO:1905207 biolink:BiologicalProcess regulation of cardiocyte differentiation Any process that modulates the frequency, rate or extent of cardiocyte differentiation. go.json regulation of cardiac cell differentiation|regulation of heart cell differentiation http://purl.obolibrary.org/obo/GO_1905207 GO:1905208 biolink:BiologicalProcess negative regulation of cardiocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. go.json down regulation of cardiac cell differentiation|down regulation of cardiocyte differentiation|down regulation of heart cell differentiation|down-regulation of cardiac cell differentiation|down-regulation of cardiocyte differentiation|down-regulation of heart cell differentiation|downregulation of cardiac cell differentiation|downregulation of cardiocyte differentiation|downregulation of heart cell differentiation|inhibition of cardiac cell differentiation|inhibition of cardiocyte differentiation|inhibition of heart cell differentiation|negative regulation of cardiac cell differentiation|negative regulation of heart cell differentiation http://purl.obolibrary.org/obo/GO_1905208 GO:0090648 biolink:BiologicalProcess response to environmental enrichment Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment. go.json response to the introduction of novel objects http://purl.obolibrary.org/obo/GO_0090648 GO:0090649 biolink:BiologicalProcess response to oxygen-glucose deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. go.json response to OGD http://purl.obolibrary.org/obo/GO_0090649 GO:1905209 biolink:BiologicalProcess positive regulation of cardiocyte differentiation Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. go.json activation of cardiac cell differentiation|activation of cardiocyte differentiation|activation of heart cell differentiation|positive regulation of cardiac cell differentiation|positive regulation of heart cell differentiation|up regulation of cardiac cell differentiation|up regulation of cardiocyte differentiation|up regulation of heart cell differentiation|up-regulation of cardiac cell differentiation|up-regulation of cardiocyte differentiation|up-regulation of heart cell differentiation|upregulation of cardiac cell differentiation|upregulation of cardiocyte differentiation|upregulation of heart cell differentiation http://purl.obolibrary.org/obo/GO_1905209 GO:0051030 biolink:BiologicalProcess snRNA transport The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051030 GO:0051031 biolink:BiologicalProcess tRNA transport The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051031 GO:0075000 biolink:BiologicalProcess response to host osmotic environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response of symbiont to host osmotic environment http://purl.obolibrary.org/obo/GO_0075000 GO:0090642 biolink:CellularComponent microsporidian-type exospore The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore. go.json http://purl.obolibrary.org/obo/GO_0090642 GO:0051034 biolink:MolecularActivity tRNA transmembrane transporter activity Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0051034 GO:0075001 biolink:BiologicalProcess adhesion of symbiont infection structure to host The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont infection structure to host during symbiotic interaction|attachment of symbiont infection structure to host http://purl.obolibrary.org/obo/GO_0075001 GO:0090643 biolink:BiologicalProcess inflorescence phyllotactic patterning The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem. go.json http://purl.obolibrary.org/obo/GO_0090643 GO:0075002 biolink:BiologicalProcess adhesion of symbiont germination tube to host The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont germination tube to host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075002 GO:0051035 biolink:MolecularActivity DNA transmembrane transporter activity Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0051035 GO:0075003 biolink:BiologicalProcess adhesion of symbiont appressorium to host The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont appressorium to host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075003 GO:0090640 biolink:BiologicalProcess phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine. go.json http://purl.obolibrary.org/obo/GO_0090640 GO:0051032 biolink:MolecularActivity nucleic acid transmembrane transporter activity Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. go.json http://purl.obolibrary.org/obo/GO_0051032 GO:0090641 biolink:CellularComponent microsporidian-type endospore The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins. go.json http://purl.obolibrary.org/obo/GO_0090641 GO:0051033 biolink:MolecularActivity RNA transmembrane transporter activity Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. Reactome:R-HSA-203906 go.json http://purl.obolibrary.org/obo/GO_0051033 GO:0075004 biolink:BiologicalProcess adhesion of symbiont spore to host The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont spore to host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075004 GO:0051049 biolink:BiologicalProcess regulation of transport Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051049 goslim_yeast GO:0051047 biolink:BiologicalProcess positive regulation of secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. go.json activation of secretion|stimulation of secretion|up regulation of secretion|up-regulation of secretion|upregulation of secretion http://purl.obolibrary.org/obo/GO_0051047 GO:0051048 biolink:BiologicalProcess negative regulation of secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. go.json down regulation of secretion|down-regulation of secretion|downregulation of secretion|inhibition of secretion http://purl.obolibrary.org/obo/GO_0051048 GO:1905220 biolink:BiologicalProcess negative regulation of platelet formation Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation. go.json down regulation of platelet extrusion|down regulation of platelet formation|down-regulation of platelet extrusion|down-regulation of platelet formation|downregulation of platelet extrusion|downregulation of platelet formation|inhibition of platelet extrusion|inhibition of platelet formation|negative regulation of platelet extrusion http://purl.obolibrary.org/obo/GO_1905220 GO:1905221 biolink:BiologicalProcess positive regulation of platelet formation Any process that activates or increases the frequency, rate or extent of platelet formation. go.json activation of platelet extrusion|activation of platelet formation|positive regulation of platelet extrusion|up regulation of platelet extrusion|up regulation of platelet formation|up-regulation of platelet extrusion|up-regulation of platelet formation|upregulation of platelet extrusion|upregulation of platelet formation http://purl.obolibrary.org/obo/GO_1905221 GO:1905222 biolink:BiologicalProcess atrioventricular canal morphogenesis The developmental process by which an atrioventricular canal is generated and organized. go.json AV canal morphogenesis|AVC morphogenesis|atrial canal morphogenesis|atrio-ventricular canal morphogenesis|canalis atrioventricularis morphogenesis|ependymal canal morphogenesis http://purl.obolibrary.org/obo/GO_1905222 GO:1905223 biolink:BiologicalProcess epicardium morphogenesis The developmental process by which an epicardium is generated and organized. go.json heart epicardium morphogenesis|pericardium visceral mesothelium morphogenesis|visceral serous pericardium of heart morphogenesis|visceral serous pericardium proper morphogenesis http://purl.obolibrary.org/obo/GO_1905223 GO:1905213 biolink:BiologicalProcess negative regulation of mitotic chromosome condensation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. go.json http://purl.obolibrary.org/obo/GO_1905213 GO:0090657 biolink:BiologicalProcess telomeric loop disassembly The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication. go.json T loop disassembly|t-loop disassembly http://purl.obolibrary.org/obo/GO_0090657 GO:1905214 biolink:BiologicalProcess regulation of RNA binding Any process that modulates the frequency, rate or extent of RNA binding. go.json http://purl.obolibrary.org/obo/GO_1905214 gocheck_do_not_annotate GO:0090658 biolink:CellularComponent cone matrix sheath A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments. go.json http://purl.obolibrary.org/obo/GO_0090658 GO:0090655 biolink:MolecularActivity double-stranded/single-stranded junction telomeric DNA binding Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang. go.json http://purl.obolibrary.org/obo/GO_0090655 GO:1905215 biolink:BiologicalProcess negative regulation of RNA binding Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding. go.json down regulation of RNA binding|down-regulation of RNA binding|downregulation of RNA binding|inhibition of RNA binding http://purl.obolibrary.org/obo/GO_1905215 gocheck_do_not_annotate GO:1905216 biolink:BiologicalProcess positive regulation of RNA binding Any process that activates or increases the frequency, rate or extent of RNA binding. go.json activation of RNA binding|up regulation of RNA binding|up-regulation of RNA binding|upregulation of RNA binding http://purl.obolibrary.org/obo/GO_1905216 gocheck_do_not_annotate GO:0090656 biolink:BiologicalProcess t-circle formation A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD). go.json telomeric circle formation http://purl.obolibrary.org/obo/GO_0090656 GO:1905217 biolink:BiologicalProcess response to astaxanthin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus. go.json response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione http://purl.obolibrary.org/obo/GO_1905217 GO:1905218 biolink:BiologicalProcess cellular response to astaxanthin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus. go.json cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione http://purl.obolibrary.org/obo/GO_1905218 GO:1905219 biolink:BiologicalProcess regulation of platelet formation Any process that modulates the frequency, rate or extent of platelet formation. go.json regulation of platelet extrusion http://purl.obolibrary.org/obo/GO_1905219 GO:0090659 biolink:BiologicalProcess walking behavior The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. go.json locomotor gait pattern http://purl.obolibrary.org/obo/GO_0090659 GO:0051041 biolink:BiologicalProcess positive regulation of calcium-independent cell-cell adhesion Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion. go.json activation of calcium-independent cell-cell adhesion|stimulation of calcium-independent cell-cell adhesion|up regulation of calcium-independent cell-cell adhesion|up-regulation of calcium-independent cell-cell adhesion|upregulation of calcium-independent cell-cell adhesion http://purl.obolibrary.org/obo/GO_0051041 GO:0051042 biolink:BiologicalProcess negative regulation of calcium-independent cell-cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion. go.json down regulation of calcium-independent cell-cell adhesion|down-regulation of calcium-independent cell-cell adhesion|downregulation of calcium-independent cell-cell adhesion|inhibition of calcium-independent cell-cell adhesion http://purl.obolibrary.org/obo/GO_0051042 GO:0090650 biolink:BiologicalProcess cellular response to oxygen-glucose deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. go.json cellular response to OGD http://purl.obolibrary.org/obo/GO_0090650 GO:0051040 biolink:BiologicalProcess regulation of calcium-independent cell-cell adhesion Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. go.json http://purl.obolibrary.org/obo/GO_0051040 GO:0051045 biolink:BiologicalProcess negative regulation of membrane protein ectodomain proteolysis Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. go.json down regulation of membrane protein ectodomain proteolysis|down-regulation of membrane protein ectodomain proteolysis|downregulation of membrane protein ectodomain proteolysis|inhibition of membrane protein ectodomain proteolysis http://purl.obolibrary.org/obo/GO_0051045 GO:0090653 biolink:CellularComponent apical recycling endosome Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0090653 GO:0051046 biolink:BiologicalProcess regulation of secretion Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0051046 GO:0090654 biolink:CellularComponent basolateral recycling endosome Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0090654 GO:0090651 biolink:CellularComponent apical cytoplasm The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0090651 GO:0051043 biolink:BiologicalProcess regulation of membrane protein ectodomain proteolysis Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). go.json http://purl.obolibrary.org/obo/GO_0051043 GO:0051044 biolink:BiologicalProcess positive regulation of membrane protein ectodomain proteolysis Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. go.json activation of membrane protein ectodomain proteolysis|stimulation of membrane protein ectodomain proteolysis|up regulation of membrane protein ectodomain proteolysis|up-regulation of membrane protein ectodomain proteolysis|upregulation of membrane protein ectodomain proteolysis http://purl.obolibrary.org/obo/GO_0051044 GO:0090652 biolink:CellularComponent basolateral cytoplasm The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0090652 GO:0075027 biolink:BiologicalProcess obsolete positive regulation of appressorium initiation OBSOLETE. Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation. go.json positive regulation of appressorium initiation on or near host|positive regulation of initiation of appressorium on or near host True http://purl.obolibrary.org/obo/GO_0075027 GO:0075028 biolink:BiologicalProcess obsolete negative regulation of appressorium initiation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation. go.json negative regulation of appressorium initiation on or near host|negative regulation of initiation of appressorium on or near host True http://purl.obolibrary.org/obo/GO_0075028 GO:0051058 biolink:BiologicalProcess negative regulation of small GTPase mediated signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. go.json down regulation of small GTPase mediated signal transduction|down-regulation of small GTPase mediated signal transduction|downregulation of small GTPase mediated signal transduction|inhibition of small GTPase mediated signal transduction|negative regulation of small GTPase-mediated signal transduction http://purl.obolibrary.org/obo/GO_0051058 GO:0075029 biolink:BiologicalProcess formation of appressorium germ tube hook structure The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. go.json formation of germ tube tip of symbiont on or near the exterior of host|formation of symbiont germ tube hook structure for appressorium development|formation of symbiont germ tube hook structure on or near host|symbiont germ tube hook structure formation on or near host http://purl.obolibrary.org/obo/GO_0075029 GO:0051059 biolink:MolecularActivity NF-kappaB binding Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. go.json http://purl.obolibrary.org/obo/GO_0051059 GO:0090619 biolink:CellularComponent meiotic spindle pole Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. go.json http://purl.obolibrary.org/obo/GO_0090619 GO:1905230 biolink:BiologicalProcess response to borneol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus. go.json http://purl.obolibrary.org/obo/GO_1905230 GO:1905231 biolink:BiologicalProcess cellular response to borneol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus. go.json http://purl.obolibrary.org/obo/GO_1905231 GO:1905232 biolink:BiologicalProcess cellular response to L-glutamate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus. go.json cellular response to L-glutamate(1-) http://purl.obolibrary.org/obo/GO_1905232 GO:1905233 biolink:BiologicalProcess response to codeine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus. go.json http://purl.obolibrary.org/obo/GO_1905233 GO:1905234 biolink:BiologicalProcess cellular response to codeine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus. go.json http://purl.obolibrary.org/obo/GO_1905234 GO:1905224 biolink:BiologicalProcess obsolete clathrin-coated pit assembly OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a clathrin-coated pit. go.json clathrin-coated pit formation|coated pit assembly|coated pit formation True http://purl.obolibrary.org/obo/GO_1905224 GO:0090624 biolink:MolecularActivity endoribonuclease activity, cleaving miRNA-paired mRNA Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA. go.json http://purl.obolibrary.org/obo/GO_0090624 GO:0090625 biolink:BiologicalProcess siRNA-mediated gene silencing by mRNA destabilization An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA. go.json gene silencing by mRNA cleavage|mRNA cleavage involved in gene silencing by siRNA|mRNA destabilization-mediated gene silencing by siRNA http://purl.obolibrary.org/obo/GO_0090625 GO:1905225 biolink:BiologicalProcess response to thyrotropin-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. go.json response to TRH|response to protirelin http://purl.obolibrary.org/obo/GO_1905225 GO:1905226 biolink:BiologicalProcess obsolete regulation of adhesion of symbiont to host epithelial cell OBSOLETE. Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell. go.json True http://purl.obolibrary.org/obo/GO_1905226 GO:0090622 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090622 GO:1905227 biolink:BiologicalProcess obsolete negative regulation of adhesion of symbiont to host epithelial cell OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of adhesion of symbiont to host epithelial cell. go.json down regulation of adhesion of symbiont to host epithelial cell|down-regulation of adhesion of symbiont to host epithelial cell|downregulation of adhesion of symbiont to host epithelial cell|inhibition of adhesion of symbiont to host epithelial cell True http://purl.obolibrary.org/obo/GO_1905227 GO:0090623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090623 GO:1905228 biolink:BiologicalProcess obsolete positive regulation of adhesion of symbiont to host epithelial cell OBSOLETE. Any process that activates or increases the frequency, rate or extent of adhesion of symbiont to host epithelial cell. go.json activation of adhesion of symbiont to host epithelial cell|up regulation of adhesion of symbiont to host epithelial cell|up-regulation of adhesion of symbiont to host epithelial cell|upregulation of adhesion of symbiont to host epithelial cell True http://purl.obolibrary.org/obo/GO_1905228 GO:0090628 biolink:BiologicalProcess plant epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0090628 GO:1905229 biolink:BiologicalProcess cellular response to thyrotropin-releasing hormone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. go.json cellular response to TRH|cellular response to protirelin http://purl.obolibrary.org/obo/GO_1905229 GO:0090629 biolink:BiologicalProcess lagging strand initiation The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started. go.json http://purl.obolibrary.org/obo/GO_0090629 GO:0090626 biolink:BiologicalProcess plant epidermis morphogenesis The process in which the anatomical structures of the plant epidermis are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0090626 GO:0090627 biolink:BiologicalProcess plant epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell. go.json http://purl.obolibrary.org/obo/GO_0090627 GO:0051052 biolink:BiologicalProcess regulation of DNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. go.json regulation of DNA metabolism http://purl.obolibrary.org/obo/GO_0051052 goslim_yeast GO:0075020 biolink:BiologicalProcess obsolete calcium or calmodulin-mediated activation of appressorium formation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json Ca++ or calmodulin-mediated activation of appressorium formation|Ca2+ or calmodulin-mediated activation of appressorium formation True http://purl.obolibrary.org/obo/GO_0075020 GO:0051053 biolink:BiologicalProcess negative regulation of DNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. go.json down regulation of DNA metabolic process|down-regulation of DNA metabolic process|downregulation of DNA metabolic process|inhibition of DNA metabolic process|negative regulation of DNA metabolism http://purl.obolibrary.org/obo/GO_0051053 GO:0075021 biolink:BiologicalProcess obsolete cAMP-mediated activation of appressorium formation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json cyclic AMP mediated activation of appressorium formation True http://purl.obolibrary.org/obo/GO_0075021 GO:0051050 biolink:BiologicalProcess positive regulation of transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of transport|stimulation of transport|up regulation of transport|up-regulation of transport|upregulation of transport http://purl.obolibrary.org/obo/GO_0051050 GO:0051051 biolink:BiologicalProcess negative regulation of transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of transport|down-regulation of transport|downregulation of transport|inhibition of transport http://purl.obolibrary.org/obo/GO_0051051 GO:0075022 biolink:BiologicalProcess obsolete ethylene-mediated activation of appressorium formation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075022 GO:0090620 biolink:CellularComponent obsolete APC-Cdc20 complex OBSOLETE. An anaphase promoting complex bound to the fizzy family APC activator Cdc20/Slp1 which regulates the metaphase anaphase transition by activating the APC/C to target the anaphase inhibitor securin and promotes sister chromatid separation. go.json APC-Slp1 complex|APC-fizzy complex|mitotic anaphase promotic complex True http://purl.obolibrary.org/obo/GO_0090620 GO:0051056 biolink:BiologicalProcess regulation of small GTPase mediated signal transduction Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. go.json regulation of small GTPase-mediated signal transduction http://purl.obolibrary.org/obo/GO_0051056 GO:0075023 biolink:BiologicalProcess obsolete MAPK-mediated regulation of appressorium formation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json mitogen-activated protein kinase-mediated activation of appressorium formation True http://purl.obolibrary.org/obo/GO_0075023 GO:0090621 biolink:CellularComponent obsolete APC-fizzy-related complex OBSOLETE. An anaphase promoting complex bound to the fizzy-related family APC activator FZR1/Cdh1/Srw1 that regulates mitotic exit by activating the APC/C to target mitotic cyclins for destruction during anaphase and telophase. Is also active during G1. go.json APC-Hct1/Cdh1 complex|APC-Srw1 complex True http://purl.obolibrary.org/obo/GO_0090621 GO:0051057 biolink:BiologicalProcess positive regulation of small GTPase mediated signal transduction Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. go.json activation of small GTPase mediated signal transduction|positive regulation of small GTPase-mediated signal transduction|stimulation of small GTPase mediated signal transduction|up regulation of small GTPase mediated signal transduction|up-regulation of small GTPase mediated signal transduction|upregulation of small GTPase mediated signal transduction http://purl.obolibrary.org/obo/GO_0051057 GO:0075024 biolink:BiologicalProcess obsolete phospholipase C-mediated activation of appressorium formation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075024 GO:0051054 biolink:BiologicalProcess positive regulation of DNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. go.json activation of DNA metabolic process|positive regulation of DNA metabolism|stimulation of DNA metabolic process|up regulation of DNA metabolic process|up-regulation of DNA metabolic process|upregulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_0051054 GO:0075025 biolink:BiologicalProcess initiation of appressorium formation The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json appressorium initiation on or near host|initiation of appressorium by symbiont on or near host|initiation of appressorium on or near host|initiation of symbiont appressorium on or near host http://purl.obolibrary.org/obo/GO_0075025 GO:0051055 biolink:BiologicalProcess negative regulation of lipid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. go.json down regulation of lipid biosynthetic process|down-regulation of lipid biosynthetic process|downregulation of lipid biosynthetic process|inhibition of lipid biosynthetic process|negative regulation of lipid anabolism|negative regulation of lipid biosynthesis|negative regulation of lipid formation|negative regulation of lipid synthesis|negative regulation of lipogenesis http://purl.obolibrary.org/obo/GO_0051055 GO:0075026 biolink:BiologicalProcess obsolete regulation of appressorium initiation OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont appressorium initiation. go.json regulation of appressorium initiation on or near host|regulation of initiation of appressorium on or near host True http://purl.obolibrary.org/obo/GO_0075026 GO:0075016 biolink:BiologicalProcess appressorium formation The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. go.json appressorium formation for entry into host, on or near host|appressorium formation on or near host|formation of an appressorium by symbiont on or near host http://purl.obolibrary.org/obo/GO_0075016 GO:0075017 biolink:BiologicalProcess regulation of appressorium formation Any process that modulates the frequency, rate or extent of symbiont appressorium formation. go.json regulation of appressorium formation on or near host http://purl.obolibrary.org/obo/GO_0075017 GO:0051069 biolink:BiologicalProcess galactomannan metabolic process The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units. go.json galactomannan metabolism http://purl.obolibrary.org/obo/GO_0051069 GO:0075018 biolink:BiologicalProcess positive regulation of appressorium formation Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation. go.json positive regulation of appressorium formation on or near host http://purl.obolibrary.org/obo/GO_0075018 GO:0075019 biolink:BiologicalProcess negative regulation of appressorium formation Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation. go.json negative regulation of appressorium formation on or near host http://purl.obolibrary.org/obo/GO_0075019 GO:1905240 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation. go.json down regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|down regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|down regulation of canonical Wnt signaling pathway involved in osteoblast differentiation|down regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|down-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|down-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|down-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation|down-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|downregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|downregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|downregulation of canonical Wnt signaling pathway involved in osteoblast differentiation|downregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|inhibition of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|inhibition of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|inhibition of canonical Wnt signaling pathway involved in osteoblast differentiation|inhibition of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|negative regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|negative regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|negative regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation http://purl.obolibrary.org/obo/GO_1905240 GO:1905241 biolink:BiologicalProcess positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation. go.json activation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|activation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|activation of canonical Wnt signaling pathway involved in osteoblast differentiation|activation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|positive regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|positive regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|up regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|up regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|up regulation of canonical Wnt signaling pathway involved in osteoblast differentiation|up regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|up-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|up-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|up-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation|up-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation|upregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|upregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|upregulation of canonical Wnt signaling pathway involved in osteoblast differentiation|upregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation http://purl.obolibrary.org/obo/GO_1905241 GO:1905242 biolink:BiologicalProcess response to 3,3',5-triiodo-L-thyronine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus. go.json response to Liothyronin|response to Liothyronine|response to Liothyroninum http://purl.obolibrary.org/obo/GO_1905242 GO:1905243 biolink:BiologicalProcess cellular response to 3,3',5-triiodo-L-thyronine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus. go.json cellular response to Liothyronin|cellular response to Liothyronine|cellular response to Liothyroninum http://purl.obolibrary.org/obo/GO_1905243 GO:1905244 biolink:BiologicalProcess regulation of modification of synaptic structure Any process that modulates the frequency, rate or extent of modification of synaptic structure. go.json regulation of synapse remodelling http://purl.obolibrary.org/obo/GO_1905244 goslim_synapse GO:1905245 biolink:BiologicalProcess regulation of aspartic-type peptidase activity Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity. go.json http://purl.obolibrary.org/obo/GO_1905245 gocheck_do_not_annotate GO:0090635 biolink:CellularComponent extracellular core region of desmosome The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner. go.json desmoglea http://purl.obolibrary.org/obo/GO_0090635 GO:1905235 biolink:BiologicalProcess response to quercetin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus. go.json http://purl.obolibrary.org/obo/GO_1905235 GO:0090636 biolink:CellularComponent outer dense plaque of desmosome The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0090636 GO:1905236 biolink:BiologicalProcess cellular response to quercetin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus. go.json http://purl.obolibrary.org/obo/GO_1905236 GO:1905237 biolink:BiologicalProcess response to cyclosporin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus. go.json response to cyclophilin http://purl.obolibrary.org/obo/GO_1905237 GO:0090633 biolink:MolecularActivity keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN. go.json CMP-KDN synthetase activity|cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity http://purl.obolibrary.org/obo/GO_0090633 GO:0090634 biolink:BiologicalProcess microglial cell mediated cytotoxicity The directed killing of a target cell by a microglial cell. go.json http://purl.obolibrary.org/obo/GO_0090634 GO:1905238 biolink:BiologicalProcess cellular response to cyclosporin A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus. go.json cellular response to cyclophilin http://purl.obolibrary.org/obo/GO_1905238 GO:1905239 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway involved in osteoblast differentiation Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation. go.json regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation|regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation|regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation http://purl.obolibrary.org/obo/GO_1905239 GO:0090639 biolink:BiologicalProcess phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine. go.json http://purl.obolibrary.org/obo/GO_0090639 GO:0051060 biolink:MolecularActivity pullulanase activity Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen. EC:3.2.1.41|MetaCyc:RXN-1824 go.json R-enzyme|alpha-dextrin endo-1,6-alpha-glucosidase activity|amylopectin 6-glucanohydrolase activity|bacterial debranching enzyme|debranching enzyme activity|limit dextrinase|pullulan 6-glucanohydrolase activity|pullulan alpha-1,6-glucanohydrolase activity http://purl.obolibrary.org/obo/GO_0051060 GO:0090637 biolink:CellularComponent inner dense plaque of desmosome The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0090637 GO:0090638 biolink:BiologicalProcess phosphatidylcholine biosynthesis from phosphatidylethanolamine The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations. go.json http://purl.obolibrary.org/obo/GO_0090638 GO:0051063 biolink:MolecularActivity CDP reductase activity Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin. MetaCyc:CDPREDUCT-RXN go.json CDP reduction http://purl.obolibrary.org/obo/GO_0051063 GO:0051064 biolink:MolecularActivity TTP reductase activity Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. EC:1.17.4.- go.json TTP reduction http://purl.obolibrary.org/obo/GO_0051064 GO:0051061 biolink:MolecularActivity ADP reductase activity Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin. MetaCyc:ADPREDUCT-RXN|RHEA:28034 go.json ADP reduction http://purl.obolibrary.org/obo/GO_0051061 GO:0075010 biolink:BiologicalProcess regulation of germ tube formation Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075010 GO:0051062 biolink:MolecularActivity UDP reductase activity Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin. MetaCyc:UDPREDUCT-RXN|RHEA:28026 go.json UDP reduction http://purl.obolibrary.org/obo/GO_0051062 GO:0075011 biolink:BiologicalProcess positive regulation of germ tube formation Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of germ tube formation on or near host http://purl.obolibrary.org/obo/GO_0075011 GO:0051067 biolink:BiologicalProcess dihydropteridine metabolic process The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4. go.json 6,7-dihydropteridine metabolic process|dihydropteridine metabolism|dihydropteridine reduction http://purl.obolibrary.org/obo/GO_0051067 GO:0075012 biolink:BiologicalProcess negative regulation of germ tube formation Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of germ tube formation on or near host http://purl.obolibrary.org/obo/GO_0075012 GO:0090631 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090631 GO:0090632 biolink:MolecularActivity N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc. go.json CMP-Neu5Gc synthetase activity http://purl.obolibrary.org/obo/GO_0090632 GO:0051068 biolink:BiologicalProcess dihydrolipoamide metabolic process The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor. go.json dihydrolipoamide metabolism|dihydrolipoamide reduction|dihydrothioctamide metabolic process|dihydrothioctamide metabolism http://purl.obolibrary.org/obo/GO_0051068 GO:0075013 biolink:BiologicalProcess obsolete growth or development of symbiont on or near host phyllosphere OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of symbiont on or near host phyllosphere True http://purl.obolibrary.org/obo/GO_0075013 GO:0051065 biolink:MolecularActivity CTP reductase activity Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. EC:1.17.4.- go.json CTP reduction http://purl.obolibrary.org/obo/GO_0051065 GO:0075014 biolink:BiologicalProcess obsolete growth or development of symbiont on or near host rhizosphere OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of symbiont on or near host rhizosphere True http://purl.obolibrary.org/obo/GO_0075014 GO:0090630 biolink:BiologicalProcess activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. go.json ARF GTPase activation|Cdc42 GTPase activation|Rab GTPase activation|Rac GTPase activation|Ral GTPase activation|Ran GTPase activation|Rap GTPase activation|Ras GTPase activation|Rho GTPase activation|activation of ARF GTPase activity|activation of Cdc42 GTPase activity|activation of Rab GTPase activity|activation of Rac GTPase activity|activation of Ral GTPase activity|activation of Ran GTPase activity|activation of Rap GTPase activity|activation of Ras GTPase activity|activation of Rho GTPase activity http://purl.obolibrary.org/obo/GO_0090630 gocheck_do_not_annotate GO:0051066 biolink:BiologicalProcess dihydrobiopterin metabolic process The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions. go.json 6,7-dihydrobiopterin metabolic process|7,8-dihydrobiopterin metabolic process|dihydrobiopterin reduction|dihydropterin metabolic process|dihydropterin metabolism http://purl.obolibrary.org/obo/GO_0051066 GO:0075015 biolink:BiologicalProcess formation of infection structure The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by symbiont of infection structure on or near host|formation of host infection structure|formation of host penetration structure|formation of infection structure on or near host http://purl.obolibrary.org/obo/GO_0075015 GO:2000225 biolink:BiologicalProcess negative regulation of testosterone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_2000225 GO:2000226 biolink:BiologicalProcess regulation of pancreatic A cell differentiation Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. go.json regulation of pancreatic alpha cell differentiation http://purl.obolibrary.org/obo/GO_2000226 GO:2000227 biolink:BiologicalProcess negative regulation of pancreatic A cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. go.json negative regulation of pancreatic alpha cell differentiation http://purl.obolibrary.org/obo/GO_2000227 GO:2000228 biolink:BiologicalProcess positive regulation of pancreatic A cell differentiation Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. go.json positive regulation of pancreatic alpha cell differentiation http://purl.obolibrary.org/obo/GO_2000228 GO:0016628 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.3.1.-|Reactome:R-HSA-4419979|Reactome:R-HSA-4755572|Reactome:R-HSA-9661726|Reactome:R-HSA-9661745 go.json http://purl.obolibrary.org/obo/GO_0016628 GO:2000229 biolink:BiologicalProcess regulation of pancreatic stellate cell proliferation Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000229 GO:0016629 biolink:MolecularActivity 12-oxophytodienoate reductase activity Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + H+ + NADPH. EC:1.3.1.42|KEGG_REACTION:R03401|MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN|RHEA:21888 go.json 12-oxo-phytodienoate reductase activity|12-oxo-phytodienoic acid reductase activity|8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016629 GO:0016624 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. EC:1.2.4.- go.json oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor http://purl.obolibrary.org/obo/GO_0016624 GO:0016625 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.2.7.- go.json oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0016625 GO:0016626 biolink:MolecularActivity obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome. go.json oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016626 GO:0016627 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.3.-.-|Reactome:R-HSA-2995334|Reactome:R-HSA-9661710 go.json oxidoreductase activity, acting on the CH-CH group of donors, other acceptors http://purl.obolibrary.org/obo/GO_0016627 GO:2000220 biolink:BiologicalProcess regulation of pseudohyphal growth Any process that modulates the frequency, rate or extent of pseudohyphal growth. go.json http://purl.obolibrary.org/obo/GO_2000220 GO:0016620 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.2.1.-|Reactome:R-HSA-1222583 go.json http://purl.obolibrary.org/obo/GO_0016620 GO:2000221 biolink:BiologicalProcess negative regulation of pseudohyphal growth Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth. go.json http://purl.obolibrary.org/obo/GO_2000221 GO:2000222 biolink:BiologicalProcess positive regulation of pseudohyphal growth Any process that activates or increases the frequency, rate or extent of pseudohyphal growth. go.json http://purl.obolibrary.org/obo/GO_2000222 GO:0016621 biolink:MolecularActivity cinnamoyl-CoA reductase activity Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+. EC:1.2.1.44|MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN|RHEA:10620 go.json cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)|cinnamoyl CoA reductase activity|cinnamoyl-CoA:NADPH reductase activity|cinnamoyl-coenzyme A reductase activity|feruloyl coenzyme A reductase activity|feruloyl-CoA reductase activity|ferulyl-CoA reductase activity|p-hydroxycinnamoyl coenzyme A reductase activity http://purl.obolibrary.org/obo/GO_0016621 GO:2000223 biolink:BiologicalProcess obsolete regulation of BMP signaling pathway involved in heart jogging OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging. go.json regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis True http://purl.obolibrary.org/obo/GO_2000223 GO:0016622 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome. EC:1.2.2.- go.json http://purl.obolibrary.org/obo/GO_0016622 GO:2000224 biolink:BiologicalProcess regulation of testosterone biosynthetic process Any process that modulates the frequency, rate or extent of testosterone biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_2000224 GO:0016623 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. EC:1.2.3.- go.json http://purl.obolibrary.org/obo/GO_0016623 GO:2000236 biolink:BiologicalProcess negative regulation of tRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing. go.json negative regulation of tRNA maturation http://purl.obolibrary.org/obo/GO_2000236 GO:2000237 biolink:BiologicalProcess positive regulation of tRNA processing Any process that activates or increases the frequency, rate or extent of tRNA processing. go.json positive regulation of tRNA maturation http://purl.obolibrary.org/obo/GO_2000237 GO:2000238 biolink:BiologicalProcess regulation of tRNA export from nucleus Any process that modulates the frequency, rate or extent of tRNA export from nucleus. go.json regulation of tRNA export from cell nucleus|regulation of tRNA export out of nucleus|regulation of tRNA transport from nucleus to cytoplasm|regulation of tRNA-nucleus export http://purl.obolibrary.org/obo/GO_2000238 GO:2000239 biolink:BiologicalProcess negative regulation of tRNA export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus. go.json negative regulation of tRNA export from cell nucleus|negative regulation of tRNA export out of nucleus|negative regulation of tRNA transport from nucleus to cytoplasm|negative regulation of tRNA-nucleus export http://purl.obolibrary.org/obo/GO_2000239 GO:0016639 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. EC:1.4.1.- go.json http://purl.obolibrary.org/obo/GO_0016639 GO:0016635 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. EC:1.3.5.- go.json http://purl.obolibrary.org/obo/GO_0016635 GO:0016636 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.3.7.- go.json oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0016636 GO:2000230 biolink:BiologicalProcess negative regulation of pancreatic stellate cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000230 GO:0016637 biolink:MolecularActivity obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen. go.json oxidoreductase activity, acting on the CH-CH group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016637 GO:0016638 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.4.-.- go.json oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors http://purl.obolibrary.org/obo/GO_0016638 GO:2000231 biolink:BiologicalProcess positive regulation of pancreatic stellate cell proliferation Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000231 GO:0016631 biolink:MolecularActivity enoyl-[acyl-carrier-protein] reductase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+. MetaCyc:RXN1G-2527|MetaCyc:RXN1G-2544|MetaCyc:RXN1G-3232|MetaCyc:RXN1G-3256|MetaCyc:RXN1G-3613|MetaCyc:RXN1G-3641|MetaCyc:RXN1G-3667|MetaCyc:RXN1G-3993|MetaCyc:RXN1G-4140|MetaCyc:RXN1G-45|Wikipedia:Enoyl-acyl_carrier_protein_reductase go.json enoyl-ACP reductase activity|enoyl-[acyl-carrier protein] reductase activity|enoyl-acyl carrier protein reductase http://purl.obolibrary.org/obo/GO_0016631 GO:2000232 biolink:BiologicalProcess regulation of rRNA processing Any process that modulates the frequency, rate or extent of rRNA processing. go.json regulation of 35S primary transcript processing http://purl.obolibrary.org/obo/GO_2000232 GO:0016632 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome. EC:1.3.2.- go.json http://purl.obolibrary.org/obo/GO_0016632 GO:2000233 biolink:BiologicalProcess negative regulation of rRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing. go.json negative regulation of 35S primary transcript processing http://purl.obolibrary.org/obo/GO_2000233 GO:0016633 biolink:MolecularActivity galactonolactone dehydrogenase activity Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. EC:1.3.2.3|MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN|RHEA:32367 go.json GLDHase activity|GLDase activity|L-galactono-1,4-lactone dehydrogenase activity|L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity|L-galactono-gamma-lactone dehydrogenase activity|L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity|L-galactonolactone dehydrogenase activity http://purl.obolibrary.org/obo/GO_0016633 GO:2000234 biolink:BiologicalProcess positive regulation of rRNA processing Any process that activates or increases the frequency, rate or extent of rRNA processing. go.json positive regulation of 35S primary transcript processing http://purl.obolibrary.org/obo/GO_2000234 GO:0016634 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. EC:1.3.3.- go.json http://purl.obolibrary.org/obo/GO_0016634 GO:2000235 biolink:BiologicalProcess regulation of tRNA processing Any process that modulates the frequency, rate or extent of tRNA processing. go.json regulation of tRNA maturation http://purl.obolibrary.org/obo/GO_2000235 GO:0016630 biolink:MolecularActivity protochlorophyllide reductase activity Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+. EC:1.3.1.33|MetaCyc:RXN1F-10|RHEA:11132 go.json NADPH-protochlorophyllide oxidoreductase activity|NADPH-protochlorophyllide reductase activity|NADPH2-protochlorophyllide oxidoreductase activity|chlorophyllide-a:NADP+ 7,8-oxidoreductase activity|protochlorophyllide oxidoreductase activity|protochlorophyllide photooxidoreductase activity http://purl.obolibrary.org/obo/GO_0016630 GO:2000247 biolink:BiologicalProcess positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000247 GO:2000248 biolink:BiologicalProcess negative regulation of establishment or maintenance of neuroblast polarity Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. go.json negative regulation of establishment and/or maintenance of neuroblast cell polarity http://purl.obolibrary.org/obo/GO_2000248 GO:2000249 biolink:BiologicalProcess obsolete regulation of actin cytoskeleton reorganization OBSOLETE. Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. go.json regulation of actin cytoskeleton remodeling|regulation of actin cytoskeleton reorganisation True http://purl.obolibrary.org/obo/GO_2000249 GO:0016606 biolink:CellularComponent LYSP100-associated nuclear domain A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies. go.json LANDs http://purl.obolibrary.org/obo/GO_0016606 GO:0016607 biolink:CellularComponent nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. go.json nuclear speckle|nuclear speckles|speckle domain|speckle focus|splicing speckle http://purl.obolibrary.org/obo/GO_0016607 GO:0016608 biolink:MolecularActivity growth hormone-releasing hormone activity The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. go.json GHRF activity|GHRH activity http://purl.obolibrary.org/obo/GO_0016608 GO:0016609 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016609 GO:0016602 biolink:CellularComponent CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. go.json CBF complex|NF-Y transcription factor complex|nuclear transcription factor Y complex http://purl.obolibrary.org/obo/GO_0016602 GO:0016603 biolink:MolecularActivity glutaminyl-peptide cyclotransferase activity Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+. EC:2.3.2.5|MetaCyc:RXN-19145|RHEA:23652 go.json L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)|glutaminyl cyclase activity|glutaminyl-tRNA cyclotransferase activity|glutaminyl-transfer ribonucleate cyclotransferase activity http://purl.obolibrary.org/obo/GO_0016603 GO:2000240 biolink:BiologicalProcess positive regulation of tRNA export from nucleus Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus. go.json positive regulation of tRNA export from cell nucleus|positive regulation of tRNA export out of nucleus|positive regulation of tRNA transport from nucleus to cytoplasm|positive regulation of tRNA-nucleus export http://purl.obolibrary.org/obo/GO_2000240 GO:2000241 biolink:BiologicalProcess regulation of reproductive process Any process that modulates the frequency, rate or extent of reproductive process. go.json http://purl.obolibrary.org/obo/GO_2000241 GO:0016604 biolink:CellularComponent nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. NIF_Subcellular:sao505137457 go.json http://purl.obolibrary.org/obo/GO_0016604 GO:2000242 biolink:BiologicalProcess negative regulation of reproductive process Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. go.json http://purl.obolibrary.org/obo/GO_2000242 GO:0016605 biolink:CellularComponent PML body A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. go.json ND10|PML NB|PML nuclear body|nuclear dot http://purl.obolibrary.org/obo/GO_0016605 GO:2000243 biolink:BiologicalProcess positive regulation of reproductive process Any process that activates or increases the frequency, rate or extent of reproductive process. go.json http://purl.obolibrary.org/obo/GO_2000243 GO:2000244 biolink:BiologicalProcess regulation of FtsZ-dependent cytokinesis Any process that modulates the frequency, rate or extent of FtsZ-dependent cytokinesis. go.json regulation of prokaryote-type cytokinesis|regulation of prokaryotic fission http://purl.obolibrary.org/obo/GO_2000244 GO:2000245 biolink:BiologicalProcess negative regulation of FtsZ-dependent cytokinesis Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis. go.json negative regulation of prokaryote-type cytokinesis|negative regulation of prokaryotic fission http://purl.obolibrary.org/obo/GO_2000245 GO:0016600 biolink:CellularComponent flotillin complex A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. go.json http://purl.obolibrary.org/obo/GO_0016600 GO:2000246 biolink:BiologicalProcess positive regulation of FtsZ-dependent cytokinesis Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis. go.json positive regulation of prokaryote-type cytokinesis|positive regulation of prokaryotic fission http://purl.obolibrary.org/obo/GO_2000246 GO:0016601 biolink:BiologicalProcess Rac protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. go.json Rac mediated signal transduction http://purl.obolibrary.org/obo/GO_0016601 GO:2000258 biolink:BiologicalProcess negative regulation of protein activation cascade Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. go.json negative regulation of protein activation pathway|negative regulation of protein activitory cascade http://purl.obolibrary.org/obo/GO_2000258 GO:2000259 biolink:BiologicalProcess positive regulation of protein activation cascade Any process that activates or increases the frequency, rate or extent of protein activation cascade. go.json positive regulation of protein activation pathway|positive regulation of protein activitory cascade http://purl.obolibrary.org/obo/GO_2000259 GO:0016617 biolink:MolecularActivity 4-oxoproline reductase activity Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+. EC:1.1.1.104|MetaCyc:4-OXOPROLINE-REDUCTASE-RXN|RHEA:13601 go.json 4-hydroxy-L-proline:NAD+ oxidoreductase activity|hydroxy-L-proline oxidase activity|hydroxyproline oxidase activity http://purl.obolibrary.org/obo/GO_0016617 GO:0016618 biolink:MolecularActivity hydroxypyruvate reductase activity Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. EC:1.1.1.81|MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN|MetaCyc:RXN0-300|RHEA:18657 go.json D-glycerate dehydrogenase activity|D-glycerate:NADP+ 2-oxidoreductase activity|NADH:hydroxypyruvate reductase activity|beta-hydroxypyruvate reductase activity http://purl.obolibrary.org/obo/GO_0016618 GO:0016619 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016619 GO:0016613 biolink:CellularComponent vanadium-iron nitrogenase complex An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. go.json vanadium-iron nitrogenase activity http://purl.obolibrary.org/obo/GO_0016613 GO:2000250 biolink:BiologicalProcess obsolete negative regulation of actin cytoskeleton reorganization OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization. go.json negative regulation of actin cytoskeleton remodeling|negative regulation of actin cytoskeleton reorganisation True http://purl.obolibrary.org/obo/GO_2000250 GO:2000251 biolink:BiologicalProcess obsolete positive regulation of actin cytoskeleton reorganization OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. go.json positive regulation of actin cytoskeleton remodeling|positive regulation of actin cytoskeleton reorganisation True http://purl.obolibrary.org/obo/GO_2000251 GO:0016614 biolink:MolecularActivity oxidoreductase activity, acting on CH-OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.1.-.-|Reactome:R-HSA-1500781 go.json oxidoreductase activity, acting on the CH-OH group of donors, other acceptors http://purl.obolibrary.org/obo/GO_0016614 GO:2000252 biolink:BiologicalProcess negative regulation of feeding behavior Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. go.json negative regulation of behavioral response to food|negative regulation of behavioural response to food|negative regulation of drinking|negative regulation of eating|negative regulation of feeding behaviour http://purl.obolibrary.org/obo/GO_2000252 GO:0016615 biolink:MolecularActivity malate dehydrogenase activity Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. go.json http://purl.obolibrary.org/obo/GO_0016615 GO:0016616 biolink:MolecularActivity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. EC:1.1.1.-|Reactome:R-HSA-975629 go.json NADH-dependent glyoxylate reductase|glycolate reductase|glyoxylic acid reductase http://purl.obolibrary.org/obo/GO_0016616 GO:2000253 biolink:BiologicalProcess positive regulation of feeding behavior Any process that activates or increases the frequency, rate or extent of feeding behavior. go.json positive regulation of behavioral response to food|positive regulation of behavioural response to food|positive regulation of drinking|positive regulation of eating|positive regulation of feeding behaviour http://purl.obolibrary.org/obo/GO_2000253 GO:2000254 biolink:BiologicalProcess regulation of male germ cell proliferation Any process that modulates the frequency, rate or extent of male germ cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000254 GO:0016610 biolink:CellularComponent nitrogenase complex An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. go.json http://purl.obolibrary.org/obo/GO_0016610 goslim_pir GO:2000255 biolink:BiologicalProcess negative regulation of male germ cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000255 GO:0016611 biolink:CellularComponent iron-iron nitrogenase complex An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. go.json http://purl.obolibrary.org/obo/GO_0016611 GO:2000256 biolink:BiologicalProcess positive regulation of male germ cell proliferation Any process that activates or increases the frequency, rate or extent of male germ cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000256 GO:0016612 biolink:CellularComponent molybdenum-iron nitrogenase complex An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. MetaCyc:CPLX-186|MetaCyc:CPLX-525 go.json molybdenum-iron nitrogenase activity http://purl.obolibrary.org/obo/GO_0016612 GO:2000257 biolink:BiologicalProcess regulation of protein activation cascade Any process that modulates the frequency, rate or extent of protein activation cascade. go.json regulation of protein activation pathway|regulation of protein activitory cascade http://purl.obolibrary.org/obo/GO_2000257 GO:2000203 biolink:BiologicalProcess regulation of ribosomal large subunit export from nucleus Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus. go.json regulation of 50S ribosomal subunit export from nucleus|regulation of 60S ribosomal subunit export from nucleus|regulation of ribosomal large subunit export from cell nucleus|regulation of ribosomal large subunit export out of nucleus|regulation of ribosomal large subunit transport from nucleus to cytoplasm|regulation of ribosomal large subunit-nucleus export http://purl.obolibrary.org/obo/GO_2000203 GO:2000204 biolink:BiologicalProcess negative regulation of ribosomal large subunit export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus. go.json negative regulation of 50S ribosomal subunit export from nucleus|negative regulation of 60S ribosomal subunit export from nucleus|negative regulation of ribosomal large subunit export from cell nucleus|negative regulation of ribosomal large subunit export out of nucleus|negative regulation of ribosomal large subunit transport from nucleus to cytoplasm|negative regulation of ribosomal large subunit-nucleus export http://purl.obolibrary.org/obo/GO_2000204 GO:2000205 biolink:BiologicalProcess positive regulation of ribosomal large subunit export from nucleus Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus. go.json positive regulation of 50S ribosomal subunit export from nucleus|positive regulation of 60S ribosomal subunit export from nucleus|positive regulation of ribosomal large subunit export from cell nucleus|positive regulation of ribosomal large subunit export out of nucleus|positive regulation of ribosomal large subunit transport from nucleus to cytoplasm|positive regulation of ribosomal large subunit-nucleus export http://purl.obolibrary.org/obo/GO_2000205 GO:2000206 biolink:BiologicalProcess regulation of ribosomal small subunit export from nucleus Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus. go.json regulation of 30S ribosomal subunit export from nucleus|regulation of 40S ribosomal subunit export from nucleus|regulation of ribosomal small subunit export from cell nucleus|regulation of ribosomal small subunit export out of nucleus|regulation of ribosomal small subunit transport from nucleus to cytoplasm|regulation of ribosomal small subunit-nucleus export http://purl.obolibrary.org/obo/GO_2000206 GO:2000207 biolink:BiologicalProcess negative regulation of ribosomal small subunit export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus. go.json negative regulation of 30S ribosomal subunit export from nucleus|negative regulation of 40S ribosomal subunit export from nucleus|negative regulation of ribosomal small subunit export from cell nucleus|negative regulation of ribosomal small subunit export out of nucleus|negative regulation of ribosomal small subunit transport from nucleus to cytoplasm|negative regulation of ribosomal small subunit-nucleus export http://purl.obolibrary.org/obo/GO_2000207 GO:2000208 biolink:BiologicalProcess positive regulation of ribosomal small subunit export from nucleus Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus. go.json positive regulation of 30S ribosomal subunit export from nucleus|positive regulation of 40S ribosomal subunit export from nucleus|positive regulation of ribosomal small subunit export from cell nucleus|positive regulation of ribosomal small subunit export out of nucleus|positive regulation of ribosomal small subunit transport from nucleus to cytoplasm|positive regulation of ribosomal small subunit-nucleus export http://purl.obolibrary.org/obo/GO_2000208 GO:2000209 biolink:BiologicalProcess regulation of anoikis Any process that modulates the frequency, rate or extent of anoikis. go.json regulation of detachment induced cell death|regulation of suspension induced apoptosis http://purl.obolibrary.org/obo/GO_2000209 GO:2000200 biolink:BiologicalProcess regulation of ribosomal subunit export from nucleus Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus. go.json regulation of ribosomal subunit export from cell nucleus|regulation of ribosomal subunit export out of nucleus|regulation of ribosomal subunit transport from nucleus to cytoplasm|regulation of ribosomal subunit-nucleus export|regulation of ribosome export from nucleus http://purl.obolibrary.org/obo/GO_2000200 GO:2000201 biolink:BiologicalProcess negative regulation of ribosomal subunit export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus. go.json negative regulation of ribosomal subunit export from cell nucleus|negative regulation of ribosomal subunit export out of nucleus|negative regulation of ribosomal subunit transport from nucleus to cytoplasm|negative regulation of ribosomal subunit-nucleus export|negative regulation of ribosome export from nucleus http://purl.obolibrary.org/obo/GO_2000201 GO:2000202 biolink:BiologicalProcess positive regulation of ribosomal subunit export from nucleus Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus. go.json positive regulation of ribosomal subunit export from cell nucleus|positive regulation of ribosomal subunit export out of nucleus|positive regulation of ribosomal subunit transport from nucleus to cytoplasm|positive regulation of ribosomal subunit-nucleus export|positive regulation of ribosome export from nucleus http://purl.obolibrary.org/obo/GO_2000202 GO:2000214 biolink:BiologicalProcess regulation of proline metabolic process Any process that modulates the frequency, rate or extent of proline metabolic process. go.json regulation of proline metabolism http://purl.obolibrary.org/obo/GO_2000214 GO:2000215 biolink:BiologicalProcess negative regulation of proline metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process. go.json negative regulation of proline metabolism http://purl.obolibrary.org/obo/GO_2000215 GO:2000216 biolink:BiologicalProcess positive regulation of proline metabolic process Any process that activates or increases the frequency, rate or extent of proline metabolic process. go.json positive regulation of proline metabolism http://purl.obolibrary.org/obo/GO_2000216 GO:2000217 biolink:BiologicalProcess regulation of invasive growth in response to glucose limitation Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation. go.json regulation of colony morphology http://purl.obolibrary.org/obo/GO_2000217 GO:2000218 biolink:BiologicalProcess negative regulation of invasive growth in response to glucose limitation Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation. go.json negative regulation of colony morphology http://purl.obolibrary.org/obo/GO_2000218 GO:2000219 biolink:BiologicalProcess positive regulation of invasive growth in response to glucose limitation Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation. go.json positive regulation of colony morphology http://purl.obolibrary.org/obo/GO_2000219 GO:2000210 biolink:BiologicalProcess positive regulation of anoikis Any process that activates or increases the frequency, rate or extent of anoikis. go.json positive regulation of detachment induced cell death|positive regulation of suspension induced apoptosis http://purl.obolibrary.org/obo/GO_2000210 GO:2000211 biolink:BiologicalProcess regulation of glutamate metabolic process Any process that modulates the frequency, rate or extent of glutamate metabolic process. go.json regulation of glutamate metabolism|regulation of glutamic acid metabolic process|regulation of glutamic acid metabolism http://purl.obolibrary.org/obo/GO_2000211 GO:2000212 biolink:BiologicalProcess negative regulation of glutamate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process. go.json negative regulation of glutamate metabolism|negative regulation of glutamic acid metabolic process|negative regulation of glutamic acid metabolism http://purl.obolibrary.org/obo/GO_2000212 GO:2000213 biolink:BiologicalProcess positive regulation of glutamate metabolic process Any process that activates or increases the frequency, rate or extent of glutamate metabolic process. go.json positive regulation of glutamate metabolism|positive regulation of glutamic acid metabolic process|positive regulation of glutamic acid metabolism http://purl.obolibrary.org/obo/GO_2000213 GO:0002067 biolink:BiologicalProcess glandular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. go.json http://purl.obolibrary.org/obo/GO_0002067 GO:0002068 biolink:BiologicalProcess glandular epithelial cell development The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. go.json http://purl.obolibrary.org/obo/GO_0002068 GO:0002069 biolink:BiologicalProcess columnar/cuboidal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. go.json http://purl.obolibrary.org/obo/GO_0002069 GO:0002063 biolink:BiologicalProcess chondrocyte development The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. go.json http://purl.obolibrary.org/obo/GO_0002063 GO:0002064 biolink:BiologicalProcess epithelial cell development The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. go.json http://purl.obolibrary.org/obo/GO_0002064 GO:0002065 biolink:BiologicalProcess columnar/cuboidal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. go.json http://purl.obolibrary.org/obo/GO_0002065 GO:0002066 biolink:BiologicalProcess columnar/cuboidal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. go.json http://purl.obolibrary.org/obo/GO_0002066 GO:0002060 biolink:MolecularActivity purine nucleobase binding Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton. go.json purine base binding|purine binding http://purl.obolibrary.org/obo/GO_0002060 GO:0002061 biolink:MolecularActivity pyrimidine nucleobase binding Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton. go.json 1,3-diazine binding|pyrimidine base binding|pyrimidine binding http://purl.obolibrary.org/obo/GO_0002061 GO:0002062 biolink:BiologicalProcess chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. go.json http://purl.obolibrary.org/obo/GO_0002062 GO:0002078 biolink:BiologicalProcess membrane fusion involved in acrosome reaction The fusion of the plasma membrane of the sperm with the outer acrosomal membrane. go.json membrane fusion involved in the acrosomal reaction http://purl.obolibrary.org/obo/GO_0002078 GO:0002079 biolink:CellularComponent inner acrosomal membrane The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0002079 GO:0002074 biolink:BiologicalProcess extraocular skeletal muscle development The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0002074 GO:0002075 biolink:BiologicalProcess somitomeric trunk muscle development The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0002075 GO:0002076 biolink:BiologicalProcess osteoblast development The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. go.json http://purl.obolibrary.org/obo/GO_0002076 GO:0002077 biolink:BiologicalProcess acrosome matrix dispersal The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0002077 GO:0002070 biolink:BiologicalProcess epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. go.json http://purl.obolibrary.org/obo/GO_0002070 GO:0002071 biolink:BiologicalProcess glandular epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. go.json http://purl.obolibrary.org/obo/GO_0002071 GO:0002072 biolink:BiologicalProcess optic cup morphogenesis involved in camera-type eye development The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. go.json optic cup morphogenesis involved in camera-style eye development http://purl.obolibrary.org/obo/GO_0002072 GO:0002073 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002073 GO:0002080 biolink:CellularComponent acrosomal membrane The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. go.json http://purl.obolibrary.org/obo/GO_0002080 GO:0002049 biolink:BiologicalProcess pyoverdine biosynthetic process The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. go.json http://purl.obolibrary.org/obo/GO_0002049 GO:0002045 biolink:BiologicalProcess regulation of cell adhesion involved in intussusceptive angiogenesis The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0002045 GO:0002046 biolink:MolecularActivity opsin binding Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. go.json metarhodopsin binding http://purl.obolibrary.org/obo/GO_0002046 GO:0002047 biolink:BiologicalProcess phenazine biosynthetic process The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. go.json acridizine biosynthesis|acridizine biosynthetic process|azophenylene biosynthesis|azophenylene biosynthetic process|dibenzo-p-diazine biosynthesis|dibenzo-p-diazine biosynthetic process|dibenzopyrazine biosynthesis|dibenzopyrazine biosynthetic process http://purl.obolibrary.org/obo/GO_0002047 GO:0002048 biolink:BiologicalProcess pyoverdine metabolic process The chemical reactions and pathways involving the siderochrome pyoverdine. go.json pyoverdine metabolism http://purl.obolibrary.org/obo/GO_0002048 GO:0002041 biolink:BiologicalProcess intussusceptive angiogenesis The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars. go.json http://purl.obolibrary.org/obo/GO_0002041 GO:0002042 biolink:BiologicalProcess cell migration involved in sprouting angiogenesis The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0002042 GO:0002043 biolink:BiologicalProcess blood vessel endothelial cell proliferation involved in sprouting angiogenesis The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis. go.json blood vessel endothelial cell proliferation during sprouting angiogenesis http://purl.obolibrary.org/obo/GO_0002043 GO:0002044 biolink:BiologicalProcess blood vessel endothelial cell migration involved in intussusceptive angiogenesis The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0002044 GO:0002040 biolink:BiologicalProcess sprouting angiogenesis The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. go.json http://purl.obolibrary.org/obo/GO_0002040 GO:0016686 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016686 GO:0016687 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016687 GO:0016688 biolink:MolecularActivity L-ascorbate peroxidase activity Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O. EC:1.11.1.11|MetaCyc:RXN-12440|RHEA:22996 go.json L-ascorbate:hydrogen-peroxide oxidoreductase activity|L-ascorbic acid peroxidase activity|L-ascorbic acid-specific peroxidase activity|ascorbate peroxidase activity|ascorbic acid peroxidase activity http://purl.obolibrary.org/obo/GO_0016688 GO:0016689 biolink:MolecularActivity manganese peroxidase activity Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O. EC:1.11.1.13|MetaCyc:MANGANESE-PEROXIDASE-RXN|RHEA:22776 go.json Mn(II):hydrogen-peroxide oxidoreductase activity|Mn-dependent (NADH-oxidizing) peroxidase activity|Mn-dependent peroxidase activity|peroxidase-M2 http://purl.obolibrary.org/obo/GO_0016689 GO:0016682 biolink:MolecularActivity oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. EC:1.10.3.- go.json laccase activity http://purl.obolibrary.org/obo/GO_0016682 GO:0016683 biolink:MolecularActivity obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen. go.json oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016683 GO:0016684 biolink:MolecularActivity oxidoreductase activity, acting on peroxide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. EC:1.11.-.- go.json http://purl.obolibrary.org/obo/GO_0016684 GO:0016685 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016685 GO:0016680 biolink:MolecularActivity oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.10.1.- go.json http://purl.obolibrary.org/obo/GO_0016680 GO:0016681 biolink:MolecularActivity obsolete oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome. EC:1.10.2.- go.json True http://purl.obolibrary.org/obo/GO_0016681 GO:0002056 biolink:MolecularActivity cytosine binding Binding to cytosine. go.json http://purl.obolibrary.org/obo/GO_0002056 GO:0002057 biolink:MolecularActivity guanine binding Binding to guanine. go.json http://purl.obolibrary.org/obo/GO_0002057 GO:0002058 biolink:MolecularActivity uracil binding Binding to uracil. go.json http://purl.obolibrary.org/obo/GO_0002058 GO:0002059 biolink:MolecularActivity thymine binding Binding to thymine. go.json http://purl.obolibrary.org/obo/GO_0002059 GO:0002052 biolink:BiologicalProcess positive regulation of neuroblast proliferation Any process that activates or increases the rate of neuroblast proliferation. go.json activation of neuroblast proliferation|stimulation of neuroblast proliferation|up regulation of neuroblast proliferation|up-regulation of neuroblast proliferation|upregulation of neuroblast proliferation http://purl.obolibrary.org/obo/GO_0002052 GO:0002053 biolink:BiologicalProcess positive regulation of mesenchymal cell proliferation The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. go.json activation of mesenchymal cell proliferation|stimulation of mesenchymal cell proliferation|up regulation of mesenchymal cell proliferation|up-regulation of mesenchymal cell proliferation|upregulation of mesenchymal cell proliferation http://purl.obolibrary.org/obo/GO_0002053 GO:0002054 biolink:MolecularActivity nucleobase binding Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. go.json http://purl.obolibrary.org/obo/GO_0002054 goslim_pir GO:0002055 biolink:MolecularActivity adenine binding Binding to adenine, a purine base. go.json 6-aminopurine binding http://purl.obolibrary.org/obo/GO_0002055 GO:0002050 biolink:BiologicalProcess pyoverdine catabolic process The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine. go.json http://purl.obolibrary.org/obo/GO_0002050 GO:0002051 biolink:BiologicalProcess osteoblast fate commitment The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. go.json http://purl.obolibrary.org/obo/GO_0002051 GO:0016697 biolink:MolecularActivity oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome. EC:1.12.2.- go.json http://purl.obolibrary.org/obo/GO_0016697 GO:0016698 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016698 GO:0016699 biolink:MolecularActivity oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein. EC:1.12.7.- go.json oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0016699 GO:0016693 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016693 GO:0016694 biolink:MolecularActivity obsolete bacterial catalase-peroxidase activity OBSOLETE. (Was not defined before being made obsolete). go.json bacterial catalase-peroxidase activity True http://purl.obolibrary.org/obo/GO_0016694 GO:0016695 biolink:MolecularActivity oxidoreductase activity, acting on hydrogen as donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor. EC:1.12.-.- go.json oxidoreductase activity, acting on hydrogen as donor, other acceptors http://purl.obolibrary.org/obo/GO_0016695 GO:0016696 biolink:MolecularActivity oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP. EC:1.12.1.- go.json http://purl.obolibrary.org/obo/GO_0016696 GO:0016690 biolink:MolecularActivity diarylpropane peroxidase activity Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O. EC:1.11.1.14|MetaCyc:RXN-17136|RHEA:30271 go.json 1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity|LiP activity|diarylpropane oxygenase activity|diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)|lignin peroxidase activity|ligninase I activity|ligninase activity http://purl.obolibrary.org/obo/GO_0016690 GO:0016691 biolink:MolecularActivity chloride peroxidase activity Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O. EC:1.11.1.10|MetaCyc:CHLORIDE-PEROXIDASE-RXN go.json chloride:hydrogen-peroxide oxidoreductase|chloroperoxidase activity|cofactor-free chloroperoxidase activity|flavin-haem chloroperoxidase activity|flavin-heme chloroperoxidase activity|haem chloroperoxidase activity|heme chloroperoxidase activity|vanadium chloroperoxidase activity http://purl.obolibrary.org/obo/GO_0016691 GO:0016692 biolink:MolecularActivity NADH peroxidase activity Catalysis of the reaction: H2O2 + NADH + H+ = 2 H2O + NAD+. EC:1.11.1.1|KEGG_REACTION:R00090|MetaCyc:NADH-PEROXIDASE-RXN|RHEA:18509 go.json DPNH peroxidase activity|NAD peroxidase activity|NADH-peroxidase activity|NADH:hydrogen-peroxide oxidoreductase activity|diphosphopyridine nucleotide peroxidase activity|nicotinamide adenine dinucleotide peroxidase activity http://purl.obolibrary.org/obo/GO_0016692 GO:0002027 biolink:BiologicalProcess regulation of heart rate Any process that modulates the frequency or rate of heart contraction. go.json cardiac chronotropy|regulation of heart contraction rate|regulation of rate of heart contraction http://purl.obolibrary.org/obo/GO_0002027 GO:0002028 biolink:BiologicalProcess regulation of sodium ion transport Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of Na+ transport|regulation of sodium transport http://purl.obolibrary.org/obo/GO_0002028 GO:0002029 biolink:BiologicalProcess desensitization of G protein-coupled receptor signaling pathway The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway. go.json desensitisation of G-protein coupled receptor protein signalling pathway|desensitization of G-protein coupled receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0002029 GO:0002023 biolink:BiologicalProcess reduction of food intake in response to dietary excess An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients. go.json http://purl.obolibrary.org/obo/GO_0002023 GO:0002024 biolink:BiologicalProcess diet induced thermogenesis The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system. go.json http://purl.obolibrary.org/obo/GO_0002024 GO:0002025 biolink:BiologicalProcess norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change. go.json noradrenaline-adrenaline vasodilation involved in regulation of blood pressure|norepinephrine-epinephrine vasodilation during blood pressure regulation|vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0002025 GO:0002026 biolink:BiologicalProcess regulation of the force of heart contraction Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. go.json cardiac inotropy|heart inotropy http://purl.obolibrary.org/obo/GO_0002026 GO:2000269 biolink:BiologicalProcess regulation of fibroblast apoptotic process Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. go.json regulation of fibroblast apoptosis http://purl.obolibrary.org/obo/GO_2000269 GO:0002020 biolink:MolecularActivity protease binding Binding to a protease or a peptidase. Reactome:R-HSA-1297354 go.json http://purl.obolibrary.org/obo/GO_0002020 GO:0002021 biolink:BiologicalProcess response to dietary excess The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. go.json http://purl.obolibrary.org/obo/GO_0002021 GO:0002022 biolink:BiologicalProcess detection of dietary excess The neurological process in which the brain senses excessive caloric intake. go.json http://purl.obolibrary.org/obo/GO_0002022 GO:0016668 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.8.1.- go.json oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor|oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor|oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor|oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016668 GO:2000261 biolink:BiologicalProcess negative regulation of blood coagulation, common pathway Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway. go.json http://purl.obolibrary.org/obo/GO_2000261 GO:0016669 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome. EC:1.8.2.- go.json oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor http://purl.obolibrary.org/obo/GO_0016669 GO:2000262 biolink:BiologicalProcess positive regulation of blood coagulation, common pathway Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway. go.json http://purl.obolibrary.org/obo/GO_2000262 GO:2000263 biolink:BiologicalProcess regulation of blood coagulation, extrinsic pathway Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway. go.json http://purl.obolibrary.org/obo/GO_2000263 GO:2000264 biolink:BiologicalProcess negative regulation of blood coagulation, extrinsic pathway Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway. go.json http://purl.obolibrary.org/obo/GO_2000264 GO:0016664 biolink:MolecularActivity oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.7.7.- go.json oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0016664 GO:2000265 biolink:BiologicalProcess positive regulation of blood coagulation, extrinsic pathway Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway. go.json http://purl.obolibrary.org/obo/GO_2000265 GO:2000266 biolink:BiologicalProcess regulation of blood coagulation, intrinsic pathway Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway. go.json http://purl.obolibrary.org/obo/GO_2000266 GO:0016665 biolink:MolecularActivity obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP. go.json oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016665 GO:2000267 biolink:BiologicalProcess negative regulation of blood coagulation, intrinsic pathway Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway. go.json http://purl.obolibrary.org/obo/GO_2000267 GO:0016666 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016666 GO:0016667 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.8.-.-|Reactome:R-HSA-2213240 go.json oxidoreductase activity, acting on sulfur group of donors, other acceptors|oxidoreductase activity, acting on sulphur group of donors http://purl.obolibrary.org/obo/GO_0016667 GO:2000268 biolink:BiologicalProcess positive regulation of blood coagulation, intrinsic pathway Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway. go.json http://purl.obolibrary.org/obo/GO_2000268 GO:0016660 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016660 GO:0016661 biolink:MolecularActivity oxidoreductase activity, acting on other nitrogenous compounds as donors Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.7.-.- go.json oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors http://purl.obolibrary.org/obo/GO_0016661 GO:0016662 biolink:MolecularActivity oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. EC:1.7.2.- go.json http://purl.obolibrary.org/obo/GO_0016662 GO:0016663 biolink:MolecularActivity oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen. EC:1.7.3.- go.json http://purl.obolibrary.org/obo/GO_0016663 GO:2000260 biolink:BiologicalProcess regulation of blood coagulation, common pathway Any process that modulates the frequency, rate or extent of blood coagulation, common pathway. go.json http://purl.obolibrary.org/obo/GO_2000260 GO:0002038 biolink:BiologicalProcess positive regulation of L-glutamate import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell. go.json activation of L-glutamate import|activation of L-glutamate transport|activation of L-glutamate uptake|positive regulation of L-glutamate import|positive regulation of L-glutamate transport|positive regulation of L-glutamate uptake|stimulation of L-glutamate transport|up regulation of L-glutamate import|up regulation of L-glutamate transport|up regulation of L-glutamate uptake|up-regulation of L-glutamate import|up-regulation of L-glutamate transport|up-regulation of L-glutamate uptake|upregulation of L-glutamate import|upregulation of L-glutamate transport|upregulation of L-glutamate uptake http://purl.obolibrary.org/obo/GO_0002038 GO:0002039 biolink:MolecularActivity p53 binding Binding to one of the p53 family of proteins. go.json http://purl.obolibrary.org/obo/GO_0002039 GO:0002034 biolink:BiologicalProcess maintenance of blood vessel diameter homeostasis by renin-angiotensin The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system. go.json regulation of blood vessel diameter by renin-angiotensin|regulation of blood vessel size by renin-angiotensin|renin-angiotensin regulation of blood vessel size http://purl.obolibrary.org/obo/GO_0002034 GO:0002035 biolink:BiologicalProcess brain renin-angiotensin system The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system. go.json http://purl.obolibrary.org/obo/GO_0002035 GO:0002036 biolink:BiologicalProcess regulation of L-glutamate import across plasma membrane Any process that modulates the frequency, rate or extent of L-glutamate import into a cell. go.json regulation of L-glutamate import|regulation of L-glutamate transport|regulation of L-glutamate uptake http://purl.obolibrary.org/obo/GO_0002036 GO:0002037 biolink:BiologicalProcess negative regulation of L-glutamate import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell. go.json down regulation of L-glutamate import|down regulation of L-glutamate transport|down regulation of L-glutamate uptake|down-regulation of L-glutamate import|down-regulation of L-glutamate transport|down-regulation of L-glutamate uptake|downregulation of L-glutamate import|downregulation of L-glutamate transport|downregulation of L-glutamate uptake|inhibition of L-glutamate import|inhibition of L-glutamate transport|inhibition of L-glutamate uptake|negative regulation of L-glutamate import|negative regulation of L-glutamate transport|negative regulation of L-glutamate uptake|regulation of L-glutamate import http://purl.obolibrary.org/obo/GO_0002037 GO:0002030 biolink:BiologicalProcess inhibitory G protein-coupled receptor phosphorylation The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site. go.json inhibitory G-protein coupled receptor phosphorylation http://purl.obolibrary.org/obo/GO_0002030 gocheck_do_not_annotate GO:0002031 biolink:BiologicalProcess G protein-coupled receptor internalization The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle. go.json G-protein coupled receptor internalization http://purl.obolibrary.org/obo/GO_0002031 GO:0002032 biolink:BiologicalProcess desensitization of G protein-coupled receptor signaling pathway by arrestin The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins. go.json arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway|arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway|arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway|desensitization of G-protein coupled receptor protein signaling pathway by arrestin http://purl.obolibrary.org/obo/GO_0002032 gocheck_do_not_annotate GO:0002033 biolink:BiologicalProcess angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure The process that increases the diameter of a blood vessel via the renin-angiotensin system. go.json vasodilation by angiotensin involved in regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0002033 GO:2000272 biolink:BiologicalProcess negative regulation of signaling receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. go.json negative regulation of receptor activity|negative regulation of signalling receptor activity http://purl.obolibrary.org/obo/GO_2000272 gocheck_do_not_annotate GO:0016679 biolink:MolecularActivity oxidoreductase activity, acting on diphenols and related substances as donors Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.10.-.- go.json oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors http://purl.obolibrary.org/obo/GO_0016679 GO:2000273 biolink:BiologicalProcess positive regulation of signaling receptor activity Any process that activates or increases the frequency, rate or extent of signaling receptor activity. go.json positive regulation of signalling receptor activity http://purl.obolibrary.org/obo/GO_2000273 gocheck_do_not_annotate GO:2000274 biolink:BiologicalProcess regulation of epithelial cell migration, open tracheal system Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system. go.json regulation of tracheal cell migration|regulation of tracheal epithelial cell migration http://purl.obolibrary.org/obo/GO_2000274 GO:2000275 biolink:BiologicalProcess regulation of oxidative phosphorylation uncoupler activity Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity. go.json regulation of mitochondrial uncoupling protein activity|regulation of uncoupling protein activity http://purl.obolibrary.org/obo/GO_2000275 gocheck_do_not_annotate GO:0016675 biolink:MolecularActivity oxidoreductase activity, acting on a heme group of donors Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.9.-.- go.json oxidoreductase activity, acting on haem group of donors|oxidoreductase activity, acting on heme group of donors, other acceptors http://purl.obolibrary.org/obo/GO_0016675 GO:2000276 biolink:BiologicalProcess negative regulation of oxidative phosphorylation uncoupler activity Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity. go.json negative regulation of mitochondrial uncoupling protein activity|negative regulation of uncoupling protein activity http://purl.obolibrary.org/obo/GO_2000276 gocheck_do_not_annotate GO:2000277 biolink:BiologicalProcess positive regulation of oxidative phosphorylation uncoupler activity Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity. go.json positive regulation of mitochondrial uncoupling protein activity|positive regulation of uncoupling protein activity http://purl.obolibrary.org/obo/GO_2000277 gocheck_do_not_annotate GO:0016676 biolink:MolecularActivity obsolete oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen. EC:1.9.3.- go.json oxidoreductase activity, acting on haem group of donors, oxygen as acceptor True http://purl.obolibrary.org/obo/GO_0016676 GO:2000278 biolink:BiologicalProcess regulation of DNA biosynthetic process Any process that modulates the frequency, rate or extent of DNA biosynthetic process. go.json regulation of DNA anabolism|regulation of DNA biosynthesis|regulation of DNA formation|regulation of DNA synthesis http://purl.obolibrary.org/obo/GO_2000278 GO:0016677 biolink:MolecularActivity oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group. EC:1.9.6.- go.json oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor http://purl.obolibrary.org/obo/GO_0016677 GO:0016678 biolink:MolecularActivity obsolete oxidoreductase activity, acting on heme group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen. go.json oxidoreductase activity, acting on haem group of donors, other acceptors|oxidoreductase activity, acting on heme group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016678 GO:2000279 biolink:BiologicalProcess negative regulation of DNA biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. go.json negative regulation of DNA anabolism|negative regulation of DNA biosynthesis|negative regulation of DNA formation|negative regulation of DNA synthesis http://purl.obolibrary.org/obo/GO_2000279 GO:0016671 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. EC:1.8.4.- go.json oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor http://purl.obolibrary.org/obo/GO_0016671 GO:0016672 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. EC:1.8.5.- go.json oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor http://purl.obolibrary.org/obo/GO_0016672 GO:0016673 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.8.7.- go.json oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0016673 GO:0016674 biolink:MolecularActivity obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome. go.json oxidoreductase activity, acting on sulfur group of donors, other acceptors|oxidoreductase activity, acting on sulphur group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016674 GO:2000270 biolink:BiologicalProcess negative regulation of fibroblast apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. go.json negative regulation of fibroblast apoptosis http://purl.obolibrary.org/obo/GO_2000270 GO:2000271 biolink:BiologicalProcess positive regulation of fibroblast apoptotic process Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. go.json positive regulation of fibroblast apoptosis http://purl.obolibrary.org/obo/GO_2000271 GO:0016670 biolink:MolecularActivity oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. EC:1.8.3.- go.json oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0016670 GO:0002005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002005 GO:0002006 biolink:BiologicalProcess vasoconstriction by vasopressin involved in systemic arterial blood pressure control The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream. go.json vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control http://purl.obolibrary.org/obo/GO_0002006 GO:0002007 biolink:BiologicalProcess detection of hypoxic conditions in blood by chemoreceptor signaling The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. go.json detection of hypoxic conditions in blood by chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0002007 GO:0002008 biolink:BiologicalProcess excitation of vasomotor center by chemoreceptor signaling The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure. go.json excitation of vasomotor center by chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0002008 GO:0002001 biolink:BiologicalProcess renin secretion into blood stream The regulated release of renin into the blood stream by juxtoglomerular cells. go.json renin release into blood stream http://purl.obolibrary.org/obo/GO_0002001 GO:0002002 biolink:BiologicalProcess regulation of angiotensin levels in blood The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation. go.json control of angiotensin levels in blood|control of blood angiotensin level|regulation of blood angiotensin level http://purl.obolibrary.org/obo/GO_0002002 GO:0002003 biolink:BiologicalProcess angiotensin maturation The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood. go.json angiotensin catabolic process in blood http://purl.obolibrary.org/obo/GO_0002003 GO:0002004 biolink:BiologicalProcess secretion of vasopressin involved in fast regulation of systemic arterial blood pressure The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure. go.json secretion of vasopressin during fast control of blood pressure|secretion of vasopressin during fast regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0002004 GO:0002000 biolink:BiologicalProcess detection of renal blood flow The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0002000 GO:2000283 biolink:BiologicalProcess negative regulation of amino acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process. go.json negative regulation of amino acid anabolism|negative regulation of amino acid biosynthesis|negative regulation of amino acid formation|negative regulation of amino acid synthesis|negative regulation of cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_2000283 GO:0016646 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.5.1.- go.json http://purl.obolibrary.org/obo/GO_0016646 GO:2000284 biolink:BiologicalProcess positive regulation of amino acid biosynthetic process Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. go.json positive regulation of amino acid anabolism|positive regulation of amino acid biosynthesis|positive regulation of amino acid formation|positive regulation of amino acid synthesis|positive regulation of cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_2000284 GO:0016647 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. EC:1.5.3.- go.json http://purl.obolibrary.org/obo/GO_0016647 GO:0016648 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide. EC:1.5.4.- go.json oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor http://purl.obolibrary.org/obo/GO_0016648 GO:2000285 biolink:BiologicalProcess obsolete negative regulation of regulation of excitatory postsynaptic membrane potential OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential. go.json negative regulation of EPSP|negative regulation of regulation of excitatory postsynaptic membrane potential True http://purl.obolibrary.org/obo/GO_2000285 GO:0016649 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. EC:1.5.5.- go.json http://purl.obolibrary.org/obo/GO_0016649 GO:2000286 biolink:BiologicalProcess receptor internalization involved in canonical Wnt signaling pathway A receptor internalization process that contributes to canonical Wnt signaling pathway. go.json receptor internalization involved in Wnt receptor signaling pathway through beta-catenin|receptor internalization involved in Wnt receptor signaling pathway via beta-catenin|receptor internalization involved in Wnt receptor signalling pathway through beta-catenin|receptor internalization involved in canonical Wnt receptor signaling pathway|receptor internalization involved in canonical Wnt receptor signalling pathway|receptor internalization involved in canonical Wnt-activated signaling pathway|receptor internalization involved in frizzled-1 receptor signaling pathway http://purl.obolibrary.org/obo/GO_2000286 GO:0016642 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group. EC:1.4.4.- go.json oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor http://purl.obolibrary.org/obo/GO_0016642 GO:2000287 biolink:BiologicalProcess positive regulation of myotome development Any process that activates or increases the frequency, rate or extent of myotome development. go.json http://purl.obolibrary.org/obo/GO_2000287 GO:0016643 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.4.7.- go.json oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0016643 GO:2000288 biolink:BiologicalProcess positive regulation of myoblast proliferation Any process that activates or increases the frequency, rate or extent of myoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_2000288 GO:0016644 biolink:MolecularActivity obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen. go.json oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016644 GO:2000289 biolink:BiologicalProcess regulation of photoreceptor cell axon guidance Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance. go.json regulation of photoreceptor cell axon pathfinding http://purl.obolibrary.org/obo/GO_2000289 GO:0016645 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.5.-.- go.json oxidoreductase activity, acting on the CH-NH group of donors, other acceptors http://purl.obolibrary.org/obo/GO_0016645 GO:0016640 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule. EC:1.4.2.- go.json http://purl.obolibrary.org/obo/GO_0016640 GO:0016641 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. EC:1.4.3.- go.json http://purl.obolibrary.org/obo/GO_0016641 GO:0002009 biolink:BiologicalProcess morphogenesis of an epithelium The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. go.json epithelium morphogenesis http://purl.obolibrary.org/obo/GO_0002009 GO:2000280 biolink:BiologicalProcess regulation of root development Any process that modulates the frequency, rate or extent of root development. go.json http://purl.obolibrary.org/obo/GO_2000280 GO:2000281 biolink:BiologicalProcess obsolete regulation of histone H3-T3 phosphorylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation. go.json True http://purl.obolibrary.org/obo/GO_2000281 GO:2000282 biolink:BiologicalProcess regulation of cellular amino acid biosynthetic process Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process. go.json regulation of amino acid biosynthetic process|regulation of cellular amino acid anabolism|regulation of cellular amino acid biosynthesis|regulation of cellular amino acid formation|regulation of cellular amino acid synthesis http://purl.obolibrary.org/obo/GO_2000282 GO:0002016 biolink:BiologicalProcess regulation of blood volume by renin-angiotensin The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. go.json renin-angiotensin control of body fluid levels|renin-angiotensin regulation of blood volume http://purl.obolibrary.org/obo/GO_0002016 GO:0002017 biolink:BiologicalProcess regulation of blood volume by renal aldosterone The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume. go.json aldosterone mediated control of body fluids|aldosterone mediated regulation of blood volume|renal regulation of blood volume by aldosterone http://purl.obolibrary.org/obo/GO_0002017 GO:0002018 biolink:BiologicalProcess renin-angiotensin regulation of aldosterone production The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. go.json renin-angiotensin control of aldosterone production http://purl.obolibrary.org/obo/GO_0002018 GO:0002019 biolink:BiologicalProcess regulation of renal output by angiotensin The process in which angiotensin directly modulates the rate of urine output by the kidney. go.json angiotensin mediated control of renal output|angiotensin mediated regulation of renal output|angiotensin-mediated regulation of renal output http://purl.obolibrary.org/obo/GO_0002019 GO:0002012 biolink:BiologicalProcess vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. go.json http://purl.obolibrary.org/obo/GO_0002012 GO:0002013 biolink:BiologicalProcess detection of carbon dioxide by vasomotor center The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0002013 GO:0002014 biolink:BiologicalProcess vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0002014 GO:0002015 biolink:BiologicalProcess regulation of systemic arterial blood pressure by atrial baroreceptor feedback A process that controls blood pressure by sensing the amount of stretch occurring in the atria. go.json atrial baroreceptor regulation of systemic arterial blood pressure|atrial control of blood pressure|atrial low pressure baroreceptor regulation of blood pressure|atrial reflex http://purl.obolibrary.org/obo/GO_0002015 GO:0002010 biolink:BiologicalProcess excitation of vasomotor center by baroreceptor signaling The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure. go.json excitation of vasomotor center by baroreceptor signalling http://purl.obolibrary.org/obo/GO_0002010 GO:0002011 biolink:BiologicalProcess morphogenesis of an epithelial sheet The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0002011 GO:2000294 biolink:BiologicalProcess positive regulation of defecation Any process that activates or increases the frequency, rate or extent of defecation. go.json http://purl.obolibrary.org/obo/GO_2000294 GO:0016657 biolink:MolecularActivity oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group. EC:1.6.6.- go.json oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor http://purl.obolibrary.org/obo/GO_0016657 GO:0016658 biolink:MolecularActivity obsolete oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor OBSOLETE. (Was not defined before being made obsolete). go.json oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor True http://purl.obolibrary.org/obo/GO_0016658 GO:2000295 biolink:BiologicalProcess regulation of hydrogen peroxide catabolic process Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process. go.json regulation of H2O2 catabolic process|regulation of H2O2 scavenging|regulation of detoxification of H2O2|regulation of detoxification of hydrogen peroxide|regulation of hydrogen peroxide breakdown|regulation of hydrogen peroxide catabolism|regulation of hydrogen peroxide degradation|regulation of hydrogen peroxide removal|regulation of hydrogen peroxide scavenging http://purl.obolibrary.org/obo/GO_2000295 GO:2000296 biolink:BiologicalProcess negative regulation of hydrogen peroxide catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process. go.json negative regulation of H2O2 catabolic process|negative regulation of H2O2 scavenging|negative regulation of detoxification of H2O2|negative regulation of detoxification of hydrogen peroxide|negative regulation of hydrogen peroxide breakdown|negative regulation of hydrogen peroxide catabolism|negative regulation of hydrogen peroxide degradation|negative regulation of hydrogen peroxide removal|negative regulation of hydrogen peroxide scavenging http://purl.obolibrary.org/obo/GO_2000296 GO:0016659 biolink:MolecularActivity obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen. go.json oxidoreductase activity, acting on NADH or NADPH, other acceptor True http://purl.obolibrary.org/obo/GO_0016659 GO:2000297 biolink:BiologicalProcess negative regulation of synapse maturation Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation. go.json negative regulation of synaptic maturation http://purl.obolibrary.org/obo/GO_2000297 GO:2000298 biolink:BiologicalProcess regulation of Rho-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity. go.json regulation of ROCK kinase activity|regulation of Rho-associated protein kinase activity http://purl.obolibrary.org/obo/GO_2000298 gocheck_do_not_annotate GO:0016653 biolink:MolecularActivity oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. EC:1.6.2.- go.json oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor|oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor http://purl.obolibrary.org/obo/GO_0016653 GO:0016654 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016654 GO:2000299 biolink:BiologicalProcess negative regulation of Rho-dependent protein serine/threonine kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity. go.json negative regulation of ROCK kinase activity|negative regulation of Rho-associated protein kinase activity http://purl.obolibrary.org/obo/GO_2000299 gocheck_do_not_annotate GO:0016655 biolink:MolecularActivity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. EC:1.6.5.- go.json oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor http://purl.obolibrary.org/obo/GO_0016655 GO:0016656 biolink:MolecularActivity monodehydroascorbate reductase (NADH) activity Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate. EC:1.6.5.4|MetaCyc:1.6.5.4-RXN|RHEA:14581 go.json AFR|AFR-reductase activity|MDAsA reductase (NADPH)|MDHA|NADH-semidehydroascorbate oxidoreductase activity|NADH:AFR oxidoreductase activity|NADH:ascorbate radical oxidoreductase activity|NADH:monodehydroascorbate oxidoreductase activity|NADH:semidehydroascorbic acid oxidoreductase activity|SDA reductase activity|ascorbate free radical reductase activity|ascorbate free-radical reductase activity|ascorbic free radical reductase activity|monodehydroascorbate reductase activity|semidehydroascorbate reductase activity http://purl.obolibrary.org/obo/GO_0016656 GO:0016650 biolink:MolecularActivity obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin. go.json oxidoreductase activity, acting on the CH-NH group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016650 GO:0016651 biolink:MolecularActivity oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.6.-.-|Reactome:R-HSA-109343|Reactome:R-HSA-8956458 go.json NAD(P)H dehydrogenase|oxidoreductase activity, acting on NADH or NADPH|oxidoreductase activity, acting on NADH or NADPH, other acceptor http://purl.obolibrary.org/obo/GO_0016651 GO:0016652 biolink:MolecularActivity oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. EC:1.6.1.- go.json oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016652 GO:2000290 biolink:BiologicalProcess regulation of myotome development Any process that modulates the frequency, rate or extent of myotome development. go.json http://purl.obolibrary.org/obo/GO_2000290 GO:2000291 biolink:BiologicalProcess regulation of myoblast proliferation Any process that modulates the frequency, rate or extent of myoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_2000291 GO:2000292 biolink:BiologicalProcess regulation of defecation Any process that modulates the frequency, rate or extent of defecation. go.json http://purl.obolibrary.org/obo/GO_2000292 GO:2000293 biolink:BiologicalProcess negative regulation of defecation Any process that stops, prevents or reduces the frequency, rate or extent of defecation. go.json http://purl.obolibrary.org/obo/GO_2000293 GO:0099137 biolink:BiologicalProcess altruistic, chimeric, non-reproductive fruiting body development Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell. go.json fully co-operative, chimeric, non-reproductive fruiting body development http://purl.obolibrary.org/obo/GO_0099137 GO:2000904 biolink:BiologicalProcess regulation of starch metabolic process Any process that modulates the frequency, rate or extent of starch metabolic process. go.json regulation of starch metabolism http://purl.obolibrary.org/obo/GO_2000904 GO:0110016 biolink:CellularComponent B-WICH complex A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself. go.json http://purl.obolibrary.org/obo/GO_0110016 GO:2000905 biolink:BiologicalProcess negative regulation of starch metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process. go.json negative regulation of starch metabolism http://purl.obolibrary.org/obo/GO_2000905 GO:0110017 biolink:BiologicalProcess cap-independent translational initiation of linear mRNA The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation. go.json http://purl.obolibrary.org/obo/GO_0110017 GO:0099138 biolink:BiologicalProcess altruistic, chimeric sorocarp development Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell. go.json fully co-operative, chimeric sorocarp development http://purl.obolibrary.org/obo/GO_0099138 GO:0110014 biolink:BiologicalProcess negative regulation of aggregation involved in sorocarp development Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. go.json http://purl.obolibrary.org/obo/GO_0110014 GO:2000906 biolink:BiologicalProcess positive regulation of starch metabolic process Any process that activates or increases the frequency, rate or extent of starch metabolic process. go.json positive regulation of starch metabolism http://purl.obolibrary.org/obo/GO_2000906 GO:0099135 biolink:BiologicalProcess chimeric colonial development Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype. go.json http://purl.obolibrary.org/obo/GO_0099135 gocheck_do_not_manually_annotate GO:0099136 biolink:BiologicalProcess chimeric non-reproductive fruiting body development Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes. go.json http://purl.obolibrary.org/obo/GO_0099136 gocheck_do_not_manually_annotate GO:2000907 biolink:BiologicalProcess negative regulation of glucomannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process. go.json negative regulation of glucomannan catabolism http://purl.obolibrary.org/obo/GO_2000907 GO:0110015 biolink:BiologicalProcess positive regulation of elastin catabolic process Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. go.json http://purl.obolibrary.org/obo/GO_0110015 GO:2000908 biolink:BiologicalProcess positive regulation of glucomannan catabolic process Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process. go.json positive regulation of glucomannan catabolism http://purl.obolibrary.org/obo/GO_2000908 GO:0110012 biolink:BiologicalProcess protein localization to P-body Any process in which a protein is transported to, or maintained at, a P-body. go.json protein localisation to P-body|protein localization to P body|protein localization to cytoplasmic mRNA processing body http://purl.obolibrary.org/obo/GO_0110012 GO:0099133 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099133 GO:2000909 biolink:BiologicalProcess regulation of sterol import Any process that modulates the frequency, rate or extent of sterol import. go.json regulation of sterol influx|regulation of sterol uptake http://purl.obolibrary.org/obo/GO_2000909 GO:0110013 biolink:BiologicalProcess positive regulation of aggregation involved in sorocarp development Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. go.json http://purl.obolibrary.org/obo/GO_0110013 GO:0099134 biolink:BiologicalProcess chimeric sorocarp development Development of a sorocarp formed by aggregation of cells with different genotypes. go.json http://purl.obolibrary.org/obo/GO_0099134 gocheck_do_not_manually_annotate GO:0099131 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099131 GO:0110010 biolink:BiologicalProcess basolateral protein secretion The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base. go.json http://purl.obolibrary.org/obo/GO_0110010 GO:0110011 biolink:BiologicalProcess regulation of basement membrane organization Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. go.json http://purl.obolibrary.org/obo/GO_0110011 GO:0099132 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099132 GO:0099130 biolink:MolecularActivity estrogen binding Binding to an estrogen. go.json http://purl.obolibrary.org/obo/GO_0099130 GO:2000900 biolink:BiologicalProcess cyclodextrin metabolic process The chemical reactions and pathways involving a cyclodextrin. go.json cyclodextrin metabolism http://purl.obolibrary.org/obo/GO_2000900 GO:2000901 biolink:BiologicalProcess cyclodextrin catabolic process The chemical reactions and pathways resulting in the breakdown of a cyclodextrin. go.json cyclodextrin catabolism http://purl.obolibrary.org/obo/GO_2000901 GO:2000902 biolink:BiologicalProcess cellooligosaccharide metabolic process The chemical reactions and pathways involving a cellooligosaccharide. go.json cellooligosaccharide metabolism http://purl.obolibrary.org/obo/GO_2000902 GO:2000903 biolink:BiologicalProcess cellooligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of a cellooligosaccharide. go.json cellooligosaccharide catabolism http://purl.obolibrary.org/obo/GO_2000903 GO:0051191 biolink:BiologicalProcess prosthetic group biosynthetic process The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. go.json coenzyme and prosthetic group biosynthesis|coenzyme and prosthetic group biosynthetic process|prosthetic group anabolism|prosthetic group biosynthesis|prosthetic group formation|prosthetic group synthesis http://purl.obolibrary.org/obo/GO_0051191 GO:0051192 biolink:MolecularActivity prosthetic group binding Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. go.json http://purl.obolibrary.org/obo/GO_0051192 GO:0075160 biolink:BiologicalProcess obsolete positive regulation of G-protein alpha subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075160 GO:0075161 biolink:BiologicalProcess obsolete negative regulation of G-protein alpha subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075161 GO:0051190 biolink:BiologicalProcess prosthetic group catabolic process The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. go.json coenzyme and prosthetic group catabolic process|coenzyme and prosthetic group catabolism|prosthetic group breakdown|prosthetic group catabolism|prosthetic group degradation http://purl.obolibrary.org/obo/GO_0051190 GO:0075162 biolink:BiologicalProcess obsolete regulation of G-protein beta subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075162 GO:0051195 biolink:BiologicalProcess obsolete negative regulation of cofactor metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. go.json down regulation of cofactor metabolic process|down-regulation of cofactor metabolic process|downregulation of cofactor metabolic process|inhibition of cofactor metabolic process|negative regulation of cofactor metabolism True http://purl.obolibrary.org/obo/GO_0051195 GO:0051196 biolink:BiologicalProcess obsolete regulation of coenzyme metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. go.json regulation of coenzyme and prosthetic group metabolic process|regulation of coenzyme and prosthetic group metabolism|regulation of coenzyme metabolism True http://purl.obolibrary.org/obo/GO_0051196 GO:0075163 biolink:BiologicalProcess obsolete positive regulation of G-protein beta subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075163 GO:0051193 biolink:BiologicalProcess obsolete regulation of cofactor metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. go.json regulation of cofactor metabolism True http://purl.obolibrary.org/obo/GO_0051193 GO:0075164 biolink:BiologicalProcess obsolete negative regulation of G-protein beta subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075164 GO:0075165 biolink:BiologicalProcess obsolete regulation of G-protein gamma subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075165 GO:0051194 biolink:BiologicalProcess obsolete positive regulation of cofactor metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. go.json activation of cofactor metabolic process|positive regulation of cofactor metabolism|stimulation of cofactor metabolic process|up regulation of cofactor metabolic process|up-regulation of cofactor metabolic process|upregulation of cofactor metabolic process True http://purl.obolibrary.org/obo/GO_0051194 GO:0075166 biolink:BiologicalProcess obsolete positive regulation of G-protein gamma subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075166 GO:0051199 biolink:BiologicalProcess obsolete regulation of prosthetic group metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. go.json regulation of coenzyme and prosthetic group metabolic process|regulation of coenzyme and prosthetic group metabolism|regulation of prosthetic group metabolism True http://purl.obolibrary.org/obo/GO_0051199 GO:0075167 biolink:BiologicalProcess obsolete negative regulation of G-protein gamma subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075167 GO:0051197 biolink:BiologicalProcess obsolete positive regulation of coenzyme metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. go.json activation of coenzyme metabolic process|positive regulation of coenzyme and prosthetic group metabolic process|positive regulation of coenzyme and prosthetic group metabolism|positive regulation of coenzyme metabolism|stimulation of coenzyme metabolic process|up regulation of coenzyme metabolic process|up-regulation of coenzyme metabolic process|upregulation of coenzyme metabolic process True http://purl.obolibrary.org/obo/GO_0051197 GO:0110018 biolink:BiologicalProcess cap-independent translational initiation of circular RNA The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation. go.json cap-independent translational initiation of circRNA http://purl.obolibrary.org/obo/GO_0110018 GO:0075168 biolink:BiologicalProcess obsolete regulation of protein kinase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont protein kinase-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075168 GO:0099139 biolink:BiologicalProcess cheating during chimeric sorocarp development Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes. go.json http://purl.obolibrary.org/obo/GO_0099139 GO:0110019 biolink:BiologicalProcess IRES-dependent translational initiation of circular RNA The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation. go.json IRES-dependent translational initiation of circRNA http://purl.obolibrary.org/obo/GO_0110019 GO:0051198 biolink:BiologicalProcess obsolete negative regulation of coenzyme metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. go.json down regulation of coenzyme metabolic process|down-regulation of coenzyme metabolic process|downregulation of coenzyme metabolic process|inhibition of coenzyme metabolic process|negative regulation of coenzyme and prosthetic group metabolic process|negative regulation of coenzyme and prosthetic group metabolism|negative regulation of coenzyme metabolism True http://purl.obolibrary.org/obo/GO_0051198 GO:0075169 biolink:BiologicalProcess obsolete positive regulation of symbiont protein kinase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075169 GO:0099148 biolink:BiologicalProcess regulation of synaptic vesicle docking Any process that modulates the frequency, rate or extent of synaptic vesicle docking. go.json http://purl.obolibrary.org/obo/GO_0099148 goslim_synapse GO:2000915 biolink:BiologicalProcess regulation of glucuronoxylan catabolic process Any process that modulates the frequency, rate or extent of glucuronoxylan catabolic process. go.json regulation of glucuronoxylan catabolism http://purl.obolibrary.org/obo/GO_2000915 GO:0110027 biolink:BiologicalProcess negative regulation of DNA strand resection involved in replication fork processing Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing. go.json http://purl.obolibrary.org/obo/GO_0110027 GO:0075159 biolink:BiologicalProcess obsolete regulation of G-protein alpha subunit-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075159 GO:0099149 biolink:BiologicalProcess regulation of postsynaptic neurotransmitter receptor internalization Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. go.json regulation of postsynaptic neurotransmitter receptor endocytosis http://purl.obolibrary.org/obo/GO_0099149 goslim_synapse GO:0110028 biolink:BiologicalProcess positive regulation of mitotic spindle organization Any process that activates or increases the frequency, rate or extent of mitotic spindle organization. go.json http://purl.obolibrary.org/obo/GO_0110028 GO:2000916 biolink:BiologicalProcess negative regulation of glucuronoxylan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process. go.json negative regulation of glucuronoxylan catabolism http://purl.obolibrary.org/obo/GO_2000916 GO:0110025 biolink:BiologicalProcess DNA strand resection involved in replication fork processing The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing. go.json http://purl.obolibrary.org/obo/GO_0110025 GO:0099146 biolink:CellularComponent obsolete intrinsic component of postsynaptic density membrane OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic specialization membrane True http://purl.obolibrary.org/obo/GO_0099146 GO:2000917 biolink:BiologicalProcess positive regulation of glucuronoxylan catabolic process Any process that activates or increases the frequency, rate or extent of glucuronoxylan catabolic process. go.json positive regulation of glucuronoxylan catabolism http://purl.obolibrary.org/obo/GO_2000917 GO:0110026 biolink:BiologicalProcess regulation of DNA strand resection involved in replication fork processing Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing. go.json http://purl.obolibrary.org/obo/GO_0110026 GO:0099147 biolink:CellularComponent extrinsic component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0099147 goslim_synapse GO:2000918 biolink:BiologicalProcess regulation of glucuronoarabinoxylan catabolic process Any process that modulates the frequency, rate or extent of glucuronoarabinoxylan catabolic process. go.json regulation of glucuronoarabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000918 GO:0099144 biolink:CellularComponent obsolete anchored component of synaptic membrane OBSOLETE. The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099144 GO:0110023 biolink:BiologicalProcess negative regulation of cardiac muscle myoblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_0110023 GO:2000919 biolink:BiologicalProcess negative regulation of glucuronoarabinoxylan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process. go.json negative regulation of glucuronoarabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000919 GO:0099145 biolink:BiologicalProcess regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane. go.json http://purl.obolibrary.org/obo/GO_0099145 goslim_synapse GO:0110024 biolink:BiologicalProcess positive regulation of cardiac muscle myoblast proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_0110024 GO:0110021 biolink:BiologicalProcess cardiac muscle myoblast proliferation The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. go.json http://purl.obolibrary.org/obo/GO_0110021 GO:0099142 biolink:MolecularActivity intracellularly ATP-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0099142 GO:0099143 biolink:CellularComponent presynaptic actin cytoskeleton The actin cytoskeleton that is part of a presynapse. go.json http://purl.obolibrary.org/obo/GO_0099143 goslim_synapse GO:0110022 biolink:BiologicalProcess regulation of cardiac muscle myoblast proliferation Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_0110022 GO:0099140 biolink:BiologicalProcess presynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0099140 goslim_synapse GO:0110020 biolink:BiologicalProcess regulation of actomyosin structure organization Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. go.json http://purl.obolibrary.org/obo/GO_0110020 GO:0099141 biolink:BiologicalProcess cellular response to protozoan Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. go.json http://purl.obolibrary.org/obo/GO_0099141 GO:2000910 biolink:BiologicalProcess negative regulation of sterol import Any process that stops, prevents or reduces the frequency, rate or extent of sterol import. go.json negative regulation of sterol influx|negative regulation of sterol uptake http://purl.obolibrary.org/obo/GO_2000910 GO:2000911 biolink:BiologicalProcess positive regulation of sterol import Any process that activates or increases the frequency, rate or extent of sterol import. go.json positive regulation of sterol influx|positive regulation of sterol uptake http://purl.obolibrary.org/obo/GO_2000911 GO:2000912 biolink:BiologicalProcess regulation of galactoglucomannan catabolic process Any process that modulates the frequency, rate or extent of galactoglucomannan catabolic process. go.json regulation of galactoglucomannan catabolism http://purl.obolibrary.org/obo/GO_2000912 GO:2000913 biolink:BiologicalProcess negative regulation of galactoglucomannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process. go.json negative regulation of galactoglucomannan catabolism http://purl.obolibrary.org/obo/GO_2000913 GO:2000914 biolink:BiologicalProcess positive regulation of galactoglucomannan catabolic process Any process that activates or increases the frequency, rate or extent of galactoglucomannan catabolic process. go.json positive regulation of galactoglucomannan catabolism http://purl.obolibrary.org/obo/GO_2000914 GO:0075150 biolink:BiologicalProcess obsolete regulation of receptor-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont receptor-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075150 GO:0075151 biolink:BiologicalProcess obsolete positive regulation of receptor-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont receptor-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075151 GO:0075152 biolink:BiologicalProcess obsolete negative regulation of receptor-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont receptor-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075152 GO:0075153 biolink:BiologicalProcess obsolete regulation of transmembrane receptor-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont transmembrane receptor-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075153 GO:0075154 biolink:BiologicalProcess obsolete positive regulation of transmembrane receptor-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075154 GO:0075155 biolink:BiologicalProcess obsolete negative regulation of transmembrane receptor-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075155 GO:0075156 biolink:BiologicalProcess obsolete regulation of G protein-coupled receptor signaling pathway in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of G-protein coupled receptor protein signaling pathway in response to host|regulation of G-protein coupled receptor protein signalling pathway in response to host|regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075156 GO:0075157 biolink:BiologicalProcess obsolete positive regulation of G protein-coupled receptor signaling pathway in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of G-protein coupled receptor protein signaling pathway in response to host|positive regulation of G-protein coupled receptor protein signalling pathway in response to host|positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075157 GO:0110029 biolink:BiologicalProcess negative regulation of meiosis I Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. go.json http://purl.obolibrary.org/obo/GO_0110029 GO:0075158 biolink:BiologicalProcess obsolete negative regulation of G protein-coupled receptor signaling pathway in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of G-protein coupled receptor protein signaling pathway in response to host|negative regulation of G-protein coupled receptor protein signalling pathway in response to host|negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075158 GO:0099115 biolink:CellularComponent chromosome, subtelomeric region A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin. SO:0001997 go.json nuclear subtelomeric heterochromatin|sub-telomeric heterochromatin|subtelomere|subtelomeric heterochromatin http://purl.obolibrary.org/obo/GO_0099115 GO:2000926 biolink:BiologicalProcess positive regulation of cellodextrin metabolic process Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process. go.json positive regulation of cellodextrin metabolism http://purl.obolibrary.org/obo/GO_2000926 GO:0110038 biolink:BiologicalProcess negative regulation of nematode male tail tip morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110038 GO:0099116 biolink:BiologicalProcess tRNA 5'-end processing The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA. go.json tRNA 5' processing http://purl.obolibrary.org/obo/GO_0099116 GO:2000927 biolink:BiologicalProcess regulation of cellodextrin catabolic process Any process that modulates the frequency, rate or extent of cellodextrin catabolic process. go.json regulation of cellodextrin catabolism http://purl.obolibrary.org/obo/GO_2000927 GO:0110039 biolink:BiologicalProcess positive regulation of nematode male tail tip morphogenesis Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110039 GO:0099113 biolink:BiologicalProcess negative regulation of presynaptic cytosolic calcium concentration Any process that decreases the concentration of calcium ions in the presynaptic cytosol. go.json http://purl.obolibrary.org/obo/GO_0099113 goslim_synapse GO:0110036 biolink:MolecularActivity C2 domain binding Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes. go.json http://purl.obolibrary.org/obo/GO_0110036 GO:2000928 biolink:BiologicalProcess negative regulation of cellodextrin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process. go.json negative regulation of cellodextrin catabolism http://purl.obolibrary.org/obo/GO_2000928 GO:0110037 biolink:BiologicalProcess regulation of nematode male tail tip morphogenesis Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0110037 GO:2000929 biolink:BiologicalProcess positive regulation of cellodextrin catabolic process Any process that activates or increases the frequency, rate or extent of cellodextrin catabolic process. go.json positive regulation of cellodextrin catabolism http://purl.obolibrary.org/obo/GO_2000929 GO:0099114 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099114 GO:0110034 biolink:BiologicalProcess negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway. go.json negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0110034 GO:0099111 biolink:BiologicalProcess microtubule-based transport A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. go.json http://purl.obolibrary.org/obo/GO_0099111 GO:0110035 biolink:MolecularActivity rDNA spacer replication fork barrier binding, bending The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. go.json http://purl.obolibrary.org/obo/GO_0110035 GO:0099112 biolink:BiologicalProcess microtubule polymerization based protein transport The transport of a protein driven by polymerization of a microtubule to which it is attached. go.json http://purl.obolibrary.org/obo/GO_0099112 GO:0110032 biolink:BiologicalProcess positive regulation of G2/MI transition of meiotic cell cycle Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0110032 GO:0110033 biolink:BiologicalProcess regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). go.json regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0110033 GO:0099110 biolink:BiologicalProcess microtubule polymerization based protein transport to cell tip cortex The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached. go.json http://purl.obolibrary.org/obo/GO_0099110 GO:0110030 biolink:BiologicalProcess regulation of G2/MI transition of meiotic cell cycle Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0110030 GO:0110031 biolink:BiologicalProcess negative regulation of G2/MI transition of meiotic cell cycle Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0110031 GO:2000920 biolink:BiologicalProcess positive regulation of glucuronoarabinoxylan catabolic process Any process that activates or increases the frequency, rate or extent of glucuronoarabinoxylan catabolic process. go.json positive regulation of glucuronoarabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000920 GO:2000921 biolink:BiologicalProcess regulation of arabinoxylan-containing compound catabolic process Any process that modulates the frequency, rate or extent of arabinoxylan-containing compound catabolic process. go.json regulation of arabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000921 GO:2000922 biolink:BiologicalProcess negative regulation of arabinoxylan-containing compound catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process. go.json negative regulation of arabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000922 GO:2000923 biolink:BiologicalProcess positive regulation of arabinoxylan-containing compound catabolic process Any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process. go.json positive regulation of arabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000923 GO:2000924 biolink:BiologicalProcess regulation of cellodextrin metabolic process Any process that modulates the frequency, rate or extent of cellodextrin metabolic process. go.json regulation of cellodextrin metabolism http://purl.obolibrary.org/obo/GO_2000924 GO:2000925 biolink:BiologicalProcess negative regulation of cellodextrin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process. go.json negative regulation of cellodextrin metabolism http://purl.obolibrary.org/obo/GO_2000925 GO:0075180 biolink:BiologicalProcess obsolete regulation of transcription in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075180 GO:0075181 biolink:BiologicalProcess obsolete positive regulation of symbiont transcription in response to host OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075181 GO:0075182 biolink:BiologicalProcess obsolete negative regulation of symbiont transcription in response to host OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075182 GO:0075183 biolink:BiologicalProcess infection cushion formation The process in which an organized mass of hyphae is formed and numerous infective hyphae develop from the hyphae mass. go.json infection cushion formation on or near host http://purl.obolibrary.org/obo/GO_0075183 GO:0075184 biolink:BiologicalProcess regulation of infection cushion formation Any process that modulates the frequency, rate or extent of symbiont infection cushion formation. go.json regulation of infection cushion formation on or near host http://purl.obolibrary.org/obo/GO_0075184 GO:0075185 biolink:BiologicalProcess positive regulation of infection cushion formation Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of infection cushion formation on or near host http://purl.obolibrary.org/obo/GO_0075185 GO:0075186 biolink:BiologicalProcess negative regulation of infection cushion formation Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of infection cushion formation on or near host http://purl.obolibrary.org/obo/GO_0075186 GO:0075187 biolink:BiologicalProcess hyphopodium formation The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json hyphopodium formation on or near host http://purl.obolibrary.org/obo/GO_0075187 GO:0075188 biolink:BiologicalProcess regulation of hyphopodium formation Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of hyphopodium formation on or near host http://purl.obolibrary.org/obo/GO_0075188 GO:0099119 biolink:MolecularActivity 3-demethylubiquinol-8 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8. go.json http://purl.obolibrary.org/obo/GO_0099119 GO:0075189 biolink:BiologicalProcess positive regulation of hyphopodium formation Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of hyphopodium formation on or near host http://purl.obolibrary.org/obo/GO_0075189 GO:0099117 biolink:BiologicalProcess protein transport along microtubule to cell tip The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_0099117 GO:0099118 biolink:BiologicalProcess microtubule-based protein transport A microtubule-based process that results in the transport of proteins. go.json http://purl.obolibrary.org/obo/GO_0099118 GO:2000937 biolink:BiologicalProcess negative regulation of cellotriose catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process. go.json negative regulation of cellotriose catabolism http://purl.obolibrary.org/obo/GO_2000937 GO:0099126 biolink:CellularComponent transforming growth factor beta complex A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP. go.json TGF-beta complex|TGF-beta dimer|TGFB complex|TGFB dimer|TGFbeta complex|TGFbeta dimer http://purl.obolibrary.org/obo/GO_0099126 GO:0099127 biolink:BiologicalProcess obsolete envenomation resulting in positive regulation of argininosuccinate synthase activity in another organism OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of the cytosolic argininosuccinate synthase in the bitten organism. go.json envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism True http://purl.obolibrary.org/obo/GO_0099127 GO:2000938 biolink:BiologicalProcess positive regulation of cellotriose catabolic process Any process that activates or increases the frequency, rate or extent of cellotriose catabolic process. go.json positive regulation of cellotriose catabolism http://purl.obolibrary.org/obo/GO_2000938 GO:0099124 biolink:BiologicalProcess axonal dopamine secretion The regulated release of dopamine from an axon. go.json axonal DA release|axonal dopamine release http://purl.obolibrary.org/obo/GO_0099124 GO:2000939 biolink:BiologicalProcess regulation of plant-type cell wall cellulose catabolic process Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose catabolic process. go.json regulation of plant-type cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_2000939 GO:0099125 biolink:CellularComponent PAK family kinase-Sog2 complex A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network. go.json http://purl.obolibrary.org/obo/GO_0099125 GO:0110045 biolink:BiologicalProcess negative regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. go.json http://purl.obolibrary.org/obo/GO_0110045 GO:0099122 biolink:MolecularActivity RNA polymerase II C-terminal domain binding Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. go.json RNAP II C-terminal binding http://purl.obolibrary.org/obo/GO_0099122 GO:0110046 biolink:BiologicalProcess signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle A signal transduction process that contributes to cell cycle switching, mitotic to meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0110046 GO:0099123 biolink:BiologicalProcess somato-dendritic dopamine secretion The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron. go.json STD DA release|STD dopamine release|somatodendritic dopamine release http://purl.obolibrary.org/obo/GO_0099123 GO:0110043 biolink:BiologicalProcess positive regulation of nematode pharynx morphogenesis Any process that activates or increases the frequency, rate or extent of nematode pharynx morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110043 GO:0099120 biolink:BiologicalProcess socially cooperative development The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies. go.json colonial development|non-reproductive fruiting body development|socially co-operative development http://purl.obolibrary.org/obo/GO_0099120 GO:0110044 biolink:BiologicalProcess regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. go.json sexual differentiation http://purl.obolibrary.org/obo/GO_0110044 GO:0099121 biolink:BiologicalProcess fungal sorus development The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure. go.json http://purl.obolibrary.org/obo/GO_0099121 GO:0110041 biolink:BiologicalProcess regulation of nematode pharynx morphogenesis Any process that modulates the frequency, rate or extent of nematode pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0110041 GO:0110042 biolink:BiologicalProcess negative regulation of nematode pharynx morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of nematode pharynx morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110042 GO:2000930 biolink:BiologicalProcess regulation of cellobiose metabolic process Any process that modulates the frequency, rate or extent of cellobiose metabolic process. go.json regulation of cellobiose metabolism http://purl.obolibrary.org/obo/GO_2000930 GO:2000931 biolink:BiologicalProcess negative regulation of cellobiose metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose metabolic process. go.json negative regulation of cellobiose metabolism http://purl.obolibrary.org/obo/GO_2000931 GO:2000932 biolink:BiologicalProcess positive regulation of cellobiose metabolic process Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process. go.json positive regulation of cellobiose metabolism http://purl.obolibrary.org/obo/GO_2000932 GO:0110040 biolink:BiologicalProcess nematode pharynx morphogenesis The process in which the anatomical structures of the nematode pharynx are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0110040 GO:2000933 biolink:BiologicalProcess regulation of cellotriose metabolic process Any process that modulates the frequency, rate or extent of cellotriose metabolic process. go.json regulation of cellotriose metabolism http://purl.obolibrary.org/obo/GO_2000933 GO:2000934 biolink:BiologicalProcess negative regulation of cellotriose metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process. go.json negative regulation of cellotriose metabolism http://purl.obolibrary.org/obo/GO_2000934 GO:2000935 biolink:BiologicalProcess positive regulation of cellotriose metabolic process Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process. go.json positive regulation of cellotriose metabolism http://purl.obolibrary.org/obo/GO_2000935 GO:2000936 biolink:BiologicalProcess regulation of cellotriose catabolic process Any process that modulates the frequency, rate or extent of cellotriose catabolic process. go.json regulation of cellotriose catabolism http://purl.obolibrary.org/obo/GO_2000936 GO:0075170 biolink:BiologicalProcess obsolete negative regulation of protein kinase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont protein kinase-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075170 GO:0075171 biolink:BiologicalProcess obsolete regulation of MAP kinase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont MAP kinase-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075171 GO:0075172 biolink:BiologicalProcess obsolete positive regulation of MAP kinase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont MAP kinase-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075172 GO:0075173 biolink:BiologicalProcess obsolete negative regulation of MAP kinase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont MAP kinase-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075173 GO:0075174 biolink:BiologicalProcess obsolete regulation of cAMP-mediated signaling in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of cAMP-mediated signal transduction in response to host|regulation of cAMP-mediated signalling in response to host|regulation of symbiont cAMP-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075174 GO:0075175 biolink:BiologicalProcess obsolete positive regulation of cAMP-mediated signaling in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of cAMP-mediated signal transduction in response to host|positive regulation of cAMP-mediated signalling in response to host|positive regulation of symbiont cAMP-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075175 GO:0075176 biolink:BiologicalProcess obsolete negative regulation of cAMP-mediated signaling in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of cAMP-mediated signal transduction in response to host|negative regulation of cAMP-mediated signalling in response to host|negative regulation of symbiont cAMP-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075176 GO:0075177 biolink:BiologicalProcess obsolete regulation of calcium or calmodulin-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host|modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075177 GO:0075178 biolink:BiologicalProcess obsolete positive regulation of calcium or calmodulin-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host|positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075178 GO:0075179 biolink:BiologicalProcess obsolete negative regulation of calcium or calmodulin-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host|negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075179 GO:0099128 biolink:CellularComponent mitochondrial iron-sulfur cluster assembly complex A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine. go.json http://purl.obolibrary.org/obo/GO_0099128 GO:0099129 biolink:BiologicalProcess cochlear outer hair cell electromotile response A rapid, force generating length change of an outer hair cell in response to electical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification. go.json http://purl.obolibrary.org/obo/GO_0099129 GO:0099179 biolink:BiologicalProcess regulation of synaptic membrane adhesion Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes. go.json regulation of synapse adhesion between pre- and post-synapse http://purl.obolibrary.org/obo/GO_0099179 goslim_synapse GO:0099177 biolink:BiologicalProcess regulation of trans-synaptic signaling Any process that modulates the frequency, rate or extent of trans-synaptic signaling. go.json http://purl.obolibrary.org/obo/GO_0099177 GO:0099178 biolink:BiologicalProcess regulation of retrograde trans-synaptic signaling by endocanabinoid Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid. go.json regulation of endocannabinoid-mediated retrograde trans-synaptic signaling http://purl.obolibrary.org/obo/GO_0099178 GO:0099175 biolink:BiologicalProcess regulation of postsynapse organization Any process that modulates the physical form of a postsynapse. go.json regulation of postsynapse organisation|regulation of postsynapse organization and biogenesis|regulation of postsynapse structure http://purl.obolibrary.org/obo/GO_0099175 goslim_synapse GO:0099176 biolink:BiologicalProcess regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex. go.json regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling http://purl.obolibrary.org/obo/GO_0099176 goslim_synapse GO:0099173 biolink:BiologicalProcess postsynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. go.json postsynapse development|postsynapse morphogenesis|postsynapse organisation|postsynapse organization and biogenesis http://purl.obolibrary.org/obo/GO_0099173 goslim_synapse GO:0099174 biolink:BiologicalProcess regulation of presynapse organization Any process that modulates the physical form of a presynapse. go.json regulation of presynapse organisation|regulation of presynapse organization and biogenesis|regulation of presynapse structure http://purl.obolibrary.org/obo/GO_0099174 goslim_synapse GO:0099171 biolink:BiologicalProcess presynaptic modulation of chemical synaptic transmission Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0099171 goslim_synapse GO:0099172 biolink:BiologicalProcess presynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. go.json presynapse development|presynapse morphogenesis|presynapse organisation|presynapse organization and biogenesis http://purl.obolibrary.org/obo/GO_0099172 goslim_synapse GO:0099170 biolink:BiologicalProcess postsynaptic modulation of chemical synaptic transmission Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0099170 goslim_synapse GO:0099188 biolink:BiologicalProcess postsynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0099188 goslim_synapse GO:0099189 biolink:CellularComponent postsynaptic spectrin-associated cytoskeleton The portion of the spectrin-associated cytoskeleton contained within the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099189 goslim_synapse GO:0099186 biolink:MolecularActivity structural constituent of postsynapse The action of a molecule that contributes to the structural integrity of a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099186 goslim_synapse GO:0099187 biolink:BiologicalProcess presynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0099187 GO:0099184 biolink:MolecularActivity structural constituent of postsynaptic intermediate filament cytoskeleton The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0099184 goslim_synapse GO:0099185 biolink:BiologicalProcess postsynaptic intermediate filament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0099185 goslim_synapse GO:0099182 biolink:CellularComponent presynaptic intermediate filament cytoskeleton The intermediate filament cytoskeleton that is part of a presynapse. go.json http://purl.obolibrary.org/obo/GO_0099182 goslim_synapse GO:0099183 biolink:BiologicalProcess trans-synaptic signaling by BDNF, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse. go.json http://purl.obolibrary.org/obo/GO_0099183 goslim_synapse GO:0099180 biolink:BiologicalProcess zinc ion import into synaptic vesicle The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle. go.json Zn2+ import into synaptic vesicle|zinc import into synaptic vesicle http://purl.obolibrary.org/obo/GO_0099180 goslim_synapse GO:0099181 biolink:MolecularActivity structural constituent of presynapse The action of a molecule that contributes to the structural integrity of a presynapse. go.json http://purl.obolibrary.org/obo/GO_0099181 goslim_synapse GO:0075190 biolink:BiologicalProcess negative regulation of hyphopodium formation Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of hyphopodium formation on or near host http://purl.obolibrary.org/obo/GO_0075190 GO:0075191 biolink:BiologicalProcess obsolete autophagy of host cells on or near symbiont surface OBSOLETE. The process in which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075191 GO:0075192 biolink:BiologicalProcess haustorium mother cell formation The process in which a symbiont cell is formed, separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json haustorium mother cell formation on or near host http://purl.obolibrary.org/obo/GO_0075192 GO:0075193 biolink:BiologicalProcess regulation of haustorium mother cell formation Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of haustorium mother cell formation on or near host http://purl.obolibrary.org/obo/GO_0075193 GO:0075194 biolink:BiologicalProcess positive regulation of haustorium mother cell formation Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of haustorium mother cell formation on or near host http://purl.obolibrary.org/obo/GO_0075194 GO:0075195 biolink:BiologicalProcess negative regulation of haustorium mother cell formation Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of haustorium mother cell formation on or near host http://purl.obolibrary.org/obo/GO_0075195 GO:0075196 biolink:BiologicalProcess adhesion of symbiont haustorium mother cell to host The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont haustorium mother cell to host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075196 GO:0075197 biolink:BiologicalProcess haustorium neck formation The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation of symbiont haustorium neck for entry into host|symbiont haustorium neck formation for entry into host http://purl.obolibrary.org/obo/GO_0075197 GO:0075198 biolink:BiologicalProcess modulation of symbiont haustorium neck formation for entry into host Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075198 GO:0075199 biolink:BiologicalProcess positive regulation of symbiont haustorium neck formation for entry into host Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075199 GO:0099159 biolink:BiologicalProcess regulation of modification of postsynaptic structure Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. go.json regulation of postsynapse remodelling http://purl.obolibrary.org/obo/GO_0099159 goslim_synapse GO:0099157 biolink:BiologicalProcess trans-synaptic signaling via exosome Transynaptic signaling in which the ligand is carried across the synapse by an exosome. go.json exosome mediated transynaptic signalling|trans-synaptic signalling via exosome http://purl.obolibrary.org/obo/GO_0099157 goslim_synapse GO:0099158 biolink:BiologicalProcess regulation of recycling endosome localization within postsynapse Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099158 goslim_synapse GO:0099155 biolink:BiologicalProcess synaptic transmission, noradrenergic The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json noradrenergic synaptic transmission http://purl.obolibrary.org/obo/GO_0099155 GO:0099156 biolink:BiologicalProcess cell-cell signaling via exosome Cell-cell signaling in which the ligand is carried between cells by an exosome. go.json exosome mediated http://purl.obolibrary.org/obo/GO_0099156 GO:0099153 biolink:BiologicalProcess synaptic transmission, serotonergic The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json serotonergic synaptic transmission http://purl.obolibrary.org/obo/GO_0099153 GO:0099154 biolink:CellularComponent serotonergic synapse A synapse that uses serotonin as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0099154 goslim_synapse GO:0099151 biolink:BiologicalProcess regulation of postsynaptic density assembly Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density. go.json http://purl.obolibrary.org/obo/GO_0099151 goslim_synapse GO:0099152 biolink:BiologicalProcess regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. go.json http://purl.obolibrary.org/obo/GO_0099152 goslim_synapse GO:0099150 biolink:BiologicalProcess regulation of postsynaptic specialization assembly Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization. go.json http://purl.obolibrary.org/obo/GO_0099150 goslim_synapse GO:0110005 biolink:BiologicalProcess positive regulation of tRNA C5-cytosine methylation Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation. go.json http://purl.obolibrary.org/obo/GO_0110005 GO:0110003 biolink:BiologicalProcess regulation of tRNA C5-cytosine methylation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA C5-cytosine methylation. go.json http://purl.obolibrary.org/obo/GO_0110003 GO:0099168 biolink:CellularComponent obsolete extrinsic component of postsynaptic specialization membrane of symmetric synapse OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json True http://purl.obolibrary.org/obo/GO_0099168 GO:0099169 biolink:CellularComponent obsolete anchored component of postsynaptic specialization membrane of symmetric synapse OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0099169 GO:0110004 biolink:BiologicalProcess positive regulation of tRNA methylation Any process that activates or increases the frequency, rate or extent of tRNA methylation. go.json http://purl.obolibrary.org/obo/GO_0110004 GO:0099166 biolink:CellularComponent obsolete intrinsic component of postsynaptic specialization membrane of symmetric synapse OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic specialization membrane of symmetric synapse True http://purl.obolibrary.org/obo/GO_0099166 GO:0110001 biolink:CellularComponent toxin-antitoxin complex A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon. go.json http://purl.obolibrary.org/obo/GO_0110001 GO:0099167 biolink:CellularComponent obsolete integral component of postsynaptic specialization membrane of symmetric synapse OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0099167 GO:0110002 biolink:BiologicalProcess regulation of tRNA methylation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation. go.json http://purl.obolibrary.org/obo/GO_0110002 GO:0099164 biolink:CellularComponent postsynaptic specialization membrane of symmetric synapse The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. go.json http://purl.obolibrary.org/obo/GO_0099164 goslim_synapse GO:0099165 biolink:CellularComponent postsynaptic specialization of symmetric synapse, intracellular component A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses. go.json http://purl.obolibrary.org/obo/GO_0099165 goslim_synapse GO:0099162 biolink:BiologicalProcess regulation of neurotransmitter loading into synaptic vesicle Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles. go.json regulation of neurotransmitter uptake into synaptic vesicle|regulation of synaptic vesicle neurotransmitter loading http://purl.obolibrary.org/obo/GO_0099162 goslim_synapse GO:0099163 biolink:BiologicalProcess synaptic signaling by nitric oxide Cell-cell signaling to or from a synapse, mediated by nitric oxide. go.json http://purl.obolibrary.org/obo/GO_0099163 goslim_synapse GO:0099160 biolink:CellularComponent postsynaptic intermediate filament cytoskeleton The intermediate filament cytoskeleton that is part of a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099160 goslim_synapse GO:0099161 biolink:BiologicalProcess regulation of presynaptic dense core granule exocytosis Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis. go.json regulation of presynaptic dense core vesicle exocytosis http://purl.obolibrary.org/obo/GO_0099161 goslim_synapse GO:0110009 biolink:BiologicalProcess formin-nucleated actin cable organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable. go.json http://purl.obolibrary.org/obo/GO_0110009 GO:0110008 biolink:BiologicalProcess ncRNA deadenylation Shortening of the poly(A) tail of a nuclear-transcribed ncRNA. go.json http://purl.obolibrary.org/obo/GO_0110008 GO:0051115 biolink:BiologicalProcess obsolete enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine OBSOLETE. The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine). RESID:AA0372 go.json True http://purl.obolibrary.org/obo/GO_0051115 GO:0051116 biolink:MolecularActivity cobaltochelatase activity Catalysis of the reaction: ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H+ + phosphate. EC:6.6.1.2|KEGG_REACTION:R05227|MetaCyc:R342-RXN|RHEA:15341 go.json CobN-CobST|CobNST|hydrogenobyrinic acid a,c-diamide cobaltochelatase activity|hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0051116 GO:0051113 biolink:BiologicalProcess obsolete enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine OBSOLETE. The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine). RESID:AA0371 go.json True http://purl.obolibrary.org/obo/GO_0051113 GO:0051114 biolink:BiologicalProcess peptidyl-histidine uridylylation The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine). RESID:AA0372 go.json http://purl.obolibrary.org/obo/GO_0051114 gocheck_do_not_annotate GO:0051119 biolink:MolecularActivity sugar transmembrane transporter activity Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. Reactome:R-HSA-428779|Reactome:R-HSA-8875902|Reactome:R-HSA-8876319 go.json sugar/polyol channel activity http://purl.obolibrary.org/obo/GO_0051119 GO:0051117 biolink:MolecularActivity ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. go.json http://purl.obolibrary.org/obo/GO_0051117 GO:0110098 biolink:BiologicalProcess positive regulation of calcium import into the mitochondrion Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0110098 GO:0051118 biolink:MolecularActivity glucan endo-1,3-alpha-glucosidase activity Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran. EC:3.2.1.59|MetaCyc:3.2.1.59-RXN go.json 1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity|cariogenanase activity|cariogenase activity|endo-(1->3)-alpha-glucanase activity|endo-1,3-alpha-D-glucanase activity|endo-1,3-alpha-glucanase activity|mutanase activity http://purl.obolibrary.org/obo/GO_0051118 GO:0110099 biolink:BiologicalProcess negative regulation of calcium import into the mitochondrion Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0110099 GO:2000984 biolink:BiologicalProcess negative regulation of ATP citrate synthase activity Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity. go.json negative regulation of ATP citrate (pro-S)-lyase activity|negative regulation of ATP-citrate (pro-S)-lyase activity|negative regulation of ATP-citrate (pro-S-)-lyase activity|negative regulation of ATP-citric lyase activity|negative regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity|negative regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)|negative regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]|negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity|negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)|negative regulation of adenosine triphosphate citrate lyase activity|negative regulation of citrate cleavage enzyme activity|negative regulation of citrate-ATP lyase activity|negative regulation of citric cleavage enzyme activity http://purl.obolibrary.org/obo/GO_2000984 gocheck_do_not_annotate GO:0110096 biolink:BiologicalProcess cellular response to aldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_0110096 GO:2000985 biolink:BiologicalProcess positive regulation of ATP citrate synthase activity Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity. go.json positive regulation of ATP citrate (pro-S)-lyase activity|positive regulation of ATP-citrate (pro-S)-lyase activity|positive regulation of ATP-citrate (pro-S-)-lyase activity|positive regulation of ATP-citric lyase activity|positive regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity|positive regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)|positive regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]|positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity|positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)|positive regulation of adenosine triphosphate citrate lyase activity|positive regulation of citrate cleavage enzyme activity|positive regulation of citrate-ATP lyase activity|positive regulation of citric cleavage enzyme activity http://purl.obolibrary.org/obo/GO_2000985 gocheck_do_not_annotate GO:0110097 biolink:BiologicalProcess regulation of calcium import into the mitochondrion Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0110097 GO:2000986 biolink:BiologicalProcess negative regulation of behavioral fear response Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response. go.json negative regulation of behavioural fear response http://purl.obolibrary.org/obo/GO_2000986 GO:0110094 biolink:BiologicalProcess polyphosphate-mediated signaling Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal. go.json polyphosphate signaling http://purl.obolibrary.org/obo/GO_0110094 GO:0090718 biolink:BiologicalProcess adaptive immune effector response An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response. go.json http://purl.obolibrary.org/obo/GO_0090718 GO:0110095 biolink:BiologicalProcess cellular detoxification of aldehyde Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. go.json http://purl.obolibrary.org/obo/GO_0110095 GO:0090719 biolink:BiologicalProcess adaptive immune effector response involving T cells and B lineage cells An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells. go.json http://purl.obolibrary.org/obo/GO_0090719 GO:2000987 biolink:BiologicalProcess positive regulation of behavioral fear response Any process that activates or increases the frequency, rate or extent of behavioral fear response. go.json positive regulation of behavioural fear response http://purl.obolibrary.org/obo/GO_2000987 GO:2000988 biolink:BiologicalProcess regulation of hemicellulose catabolic process Any process that modulates the frequency, rate or extent of hemicellulose catabolic process. go.json regulation of hemicellulose catabolism http://purl.obolibrary.org/obo/GO_2000988 GO:0110092 biolink:CellularComponent nucleus leading edge The area of a motile nucleus closest to the direction of movement. go.json horsetail nucleus leading edge http://purl.obolibrary.org/obo/GO_0110092 GO:0110093 biolink:CellularComponent nucleus lagging edge The area of a motile nucleus furthest from the direction of movement. go.json http://purl.obolibrary.org/obo/GO_0110093 GO:2000989 biolink:BiologicalProcess negative regulation of hemicellulose catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process. go.json negative regulation of hemicellulose catabolism http://purl.obolibrary.org/obo/GO_2000989 GO:1905530 biolink:BiologicalProcess negative regulation of uracil import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905530 GO:0110090 biolink:BiologicalProcess positive regulation of hippocampal neuron apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons. go.json http://purl.obolibrary.org/obo/GO_0110090 GO:1905531 biolink:BiologicalProcess positive regulation of uracil import across plasma membrane Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905531 GO:0110091 biolink:BiologicalProcess negative regulation of hippocampal neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons. go.json http://purl.obolibrary.org/obo/GO_0110091 GO:1905521 biolink:BiologicalProcess regulation of macrophage migration Any process that modulates the frequency, rate or extent of macrophage migration. go.json http://purl.obolibrary.org/obo/GO_1905521 GO:0090723 biolink:CellularComponent obsolete growth cone part OBSOLETE. Any constituent part of a growth cone, the migrating motile tip of a growing nerve cell axon or dendrite. go.json True http://purl.obolibrary.org/obo/GO_0090723 GO:0090724 biolink:CellularComponent central region of growth cone The center of the migrating motile tip of a growing nerve cell axon or dendrite. go.json http://purl.obolibrary.org/obo/GO_0090724 GO:1905522 biolink:BiologicalProcess negative regulation of macrophage migration Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. go.json down regulation of macrophage migration|down-regulation of macrophage migration|downregulation of macrophage migration|inhibition of macrophage migration http://purl.obolibrary.org/obo/GO_1905522 GO:0090721 biolink:BiologicalProcess primary adaptive immune response involving T cells and B cells An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system. go.json http://purl.obolibrary.org/obo/GO_0090721 GO:1905523 biolink:BiologicalProcess positive regulation of macrophage migration Any process that activates or increases the frequency, rate or extent of macrophage migration. go.json activation of macrophage migration|up regulation of macrophage migration|up-regulation of macrophage migration|upregulation of macrophage migration http://purl.obolibrary.org/obo/GO_1905523 GO:0090722 biolink:MolecularActivity receptor-receptor interaction The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function. go.json hetero-receptor complex formation http://purl.obolibrary.org/obo/GO_0090722 GO:1905524 biolink:BiologicalProcess negative regulation of protein autoubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination. go.json down regulation of protein auto-ubiquitination|down regulation of protein auto-ubiquitinylation|down regulation of protein autoubiquitination|down regulation of protein autoubiquitinylation|down regulation of protein self-ubiquitination|down regulation of protein self-ubiquitinylation|down-regulation of protein auto-ubiquitination|down-regulation of protein auto-ubiquitinylation|down-regulation of protein autoubiquitination|down-regulation of protein autoubiquitinylation|down-regulation of protein self-ubiquitination|down-regulation of protein self-ubiquitinylation|downregulation of protein auto-ubiquitination|downregulation of protein auto-ubiquitinylation|downregulation of protein autoubiquitination|downregulation of protein autoubiquitinylation|downregulation of protein self-ubiquitination|downregulation of protein self-ubiquitinylation|inhibition of protein auto-ubiquitination|inhibition of protein auto-ubiquitinylation|inhibition of protein autoubiquitination|inhibition of protein autoubiquitinylation|inhibition of protein self-ubiquitination|inhibition of protein self-ubiquitinylation|negative regulation of protein auto-ubiquitination|negative regulation of protein auto-ubiquitinylation|negative regulation of protein autoubiquitinylation|negative regulation of protein self-ubiquitination|negative regulation of protein self-ubiquitinylation http://purl.obolibrary.org/obo/GO_1905524 GO:1905525 biolink:BiologicalProcess obsolete regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter in response to iron that results in regulation of ferrichrome biosynthetic process. go.json regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron|regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron True http://purl.obolibrary.org/obo/GO_1905525 GO:0090727 biolink:BiologicalProcess positive regulation of brood size Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. go.json http://purl.obolibrary.org/obo/GO_0090727 GO:2000980 biolink:BiologicalProcess regulation of inner ear receptor cell differentiation Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation. go.json regulation of inner ear hair cell differentiation http://purl.obolibrary.org/obo/GO_2000980 GO:1905526 biolink:BiologicalProcess regulation of Golgi lumen acidification Any process that modulates the frequency, rate or extent of Golgi lumen acidification. go.json http://purl.obolibrary.org/obo/GO_1905526 GO:2000981 biolink:BiologicalProcess negative regulation of inner ear receptor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation. go.json negative regulation of inner ear hair cell differentiation http://purl.obolibrary.org/obo/GO_2000981 GO:0090728 biolink:BiologicalProcess negative regulation of brood size Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. go.json http://purl.obolibrary.org/obo/GO_0090728 GO:2000982 biolink:BiologicalProcess positive regulation of inner ear receptor cell differentiation Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation. go.json positive regulation of inner ear hair cell differentiation http://purl.obolibrary.org/obo/GO_2000982 GO:1905527 biolink:BiologicalProcess negative regulation of Golgi lumen acidification Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification. go.json down regulation of Golgi lumen acidification|down-regulation of Golgi lumen acidification|downregulation of Golgi lumen acidification|inhibition of Golgi lumen acidification http://purl.obolibrary.org/obo/GO_1905527 GO:0090725 biolink:CellularComponent peripheral region of growth cone The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite. go.json http://purl.obolibrary.org/obo/GO_0090725 GO:2000983 biolink:BiologicalProcess regulation of ATP citrate synthase activity Any process that modulates the frequency, rate or extent of ATP citrate synthase activity. go.json regulation of ATP citrate (pro-S)-lyase activity|regulation of ATP-citrate (pro-S)-lyase activity|regulation of ATP-citrate (pro-S-)-lyase activity|regulation of ATP-citric lyase activity|regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity|regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)|regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]|regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity|regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)|regulation of adenosine triphosphate citrate lyase activity|regulation of citrate cleavage enzyme activity|regulation of citrate-ATP lyase activity|regulation of citric cleavage enzyme activity http://purl.obolibrary.org/obo/GO_2000983 gocheck_do_not_annotate GO:1905528 biolink:BiologicalProcess positive regulation of Golgi lumen acidification Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification. go.json activation of Golgi lumen acidification|up regulation of Golgi lumen acidification|up-regulation of Golgi lumen acidification|upregulation of Golgi lumen acidification http://purl.obolibrary.org/obo/GO_1905528 GO:0090726 biolink:CellularComponent cortical dynamic polarity patch A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation. go.json dynamic polarity patch at the cell cortex http://purl.obolibrary.org/obo/GO_0090726 GO:1905529 biolink:BiologicalProcess regulation of uracil import across plasma membrane Any process that modulates the frequency, rate or extent of uracil import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905529 GO:0051111 biolink:BiologicalProcess peptidyl-histidine adenylylation The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine). RESID:AA0371 go.json http://purl.obolibrary.org/obo/GO_0051111 gocheck_do_not_annotate GO:0051112 biolink:BiologicalProcess peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine). RESID:AA0371 go.json http://purl.obolibrary.org/obo/GO_0051112 gocheck_do_not_annotate GO:0090720 biolink:BiologicalProcess primary adaptive immune response An adaptive immune response against an antigen not previously encountered by immune system. go.json http://purl.obolibrary.org/obo/GO_0090720 GO:0051110 biolink:BiologicalProcess peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine). RESID:AA0372 go.json http://purl.obolibrary.org/obo/GO_0051110 gocheck_do_not_annotate GO:0051126 biolink:BiologicalProcess negative regulation of actin nucleation Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. go.json down regulation of actin nucleation|down-regulation of actin nucleation|downregulation of actin nucleation|inhibition of actin nucleation http://purl.obolibrary.org/obo/GO_0051126 GO:0051127 biolink:BiologicalProcess positive regulation of actin nucleation Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. go.json activation of actin nucleation|stimulation of actin nucleation|up regulation of actin nucleation|up-regulation of actin nucleation|upregulation of actin nucleation http://purl.obolibrary.org/obo/GO_0051127 GO:0051124 biolink:BiologicalProcess synaptic assembly at neuromuscular junction The assembly of a synapse at a neuromuscular junction. go.json cholinergic synaptogenesis|synaptic growth at neuromuscular junction http://purl.obolibrary.org/obo/GO_0051124 GO:0051125 biolink:BiologicalProcess regulation of actin nucleation Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. go.json http://purl.obolibrary.org/obo/GO_0051125 GO:0051128 biolink:BiologicalProcess regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. go.json regulation of cell organisation|regulation of cell organization|regulation of cellular component organisation|regulation of cellular component organization and biogenesis http://purl.obolibrary.org/obo/GO_0051128 GO:0051129 biolink:BiologicalProcess negative regulation of cellular component organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. go.json down regulation of cell organization|down-regulation of cell organization|downregulation of cell organization|inhibition of cell organization|negative regulation of cell organisation|negative regulation of cellular component organization and biogenesis http://purl.obolibrary.org/obo/GO_0051129 GO:2000995 biolink:BiologicalProcess negative regulation of mannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process. go.json negative regulation of mannan breakdown|negative regulation of mannan catabolism|negative regulation of mannan degradation http://purl.obolibrary.org/obo/GO_2000995 GO:2000996 biolink:BiologicalProcess positive regulation of mannan catabolic process Any process that activates or increases the frequency, rate or extent of mannan catabolic process. go.json positive regulation of mannan breakdown|positive regulation of mannan catabolism|positive regulation of mannan degradation http://purl.obolibrary.org/obo/GO_2000996 GO:0090729 biolink:MolecularActivity toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom. Wikipedia:Toxin go.json toxin receptor binding http://purl.obolibrary.org/obo/GO_0090729 goslim_generic|prokaryote_subset GO:2000997 biolink:BiologicalProcess regulation of cellulose catabolic process Any process that modulates the frequency, rate or extent of cellulose catabolic process. go.json regulation of cellulose breakdown|regulation of cellulose catabolism|regulation of cellulose degradation http://purl.obolibrary.org/obo/GO_2000997 GO:2000998 biolink:BiologicalProcess negative regulation of cellulose catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process. go.json negative regulation of cellulose breakdown|negative regulation of cellulose catabolism|negative regulation of cellulose degradation http://purl.obolibrary.org/obo/GO_2000998 GO:2000999 biolink:BiologicalProcess positive regulation of cellulose catabolic process Any process that activates or increases the frequency, rate or extent of cellulose catabolic process. go.json positive regulation of cellulose breakdown|positive regulation of cellulose catabolism|positive regulation of cellulose degradation http://purl.obolibrary.org/obo/GO_2000999 GO:1905540 biolink:CellularComponent interleukin-7 receptor complex A protein complex that binds interleukin-7 (IL-7) and that consists of, at a minimum, an interleukin, an alpha and a gamma chain as well as optional additional kinase subunits. The alpha chain binds IL-7 with high affinity and subsequently binds the cytokine receptor common gamma chain that forms part of multiple interleukin receptors. go.json IL-7 receptor complex|IL-7-receptor complex|IL7 receptor complex|IL7-receptor complex http://purl.obolibrary.org/obo/GO_1905540 GO:1905541 biolink:BiologicalProcess regulation of L-arginine import across plasma membrane Any process that modulates the frequency, rate or extent of L-arginine import across plasma membrane. go.json regulation of L-arginine import|regulation of L-arginine import into cell http://purl.obolibrary.org/obo/GO_1905541 GO:1905542 biolink:BiologicalProcess negative regulation of L-arginine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import across plasma membrane. go.json down regulation of L-arginine import into cell|downregulation of L-arginine import into cell|inhibition of L-arginine import into cell|negative regulation of L-arginine import into cell http://purl.obolibrary.org/obo/GO_1905542 GO:1905532 biolink:BiologicalProcess regulation of leucine import across plasma membrane Any process that modulates the frequency, rate or extent of leucine import across plasma membrane. go.json regulation of L-leucine import into cell|regulation of leucine import into cell http://purl.obolibrary.org/obo/GO_1905532 GO:0090734 biolink:CellularComponent site of DNA damage A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. Wikipedia:DNA_repair go.json http://purl.obolibrary.org/obo/GO_0090734 GO:0090735 biolink:BiologicalProcess DNA repair complex assembly The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex. go.json http://purl.obolibrary.org/obo/GO_0090735 GO:1905533 biolink:BiologicalProcess negative regulation of leucine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of leucine import across plasma membrane. go.json down regulation of L-leucine import into cell|down regulation of leucine import into cell|down-regulation of L-leucine import into cell|down-regulation of leucine import into cell|downregulation of L-leucine import into cell|downregulation of leucine import into cell|inhibition of L-leucine import into cell|inhibition of leucine import into cell|negative regulation of L-leucine import into cell|negative regulation of leucine import into cell http://purl.obolibrary.org/obo/GO_1905533 GO:0090732 biolink:CellularComponent cofilin-actin rod A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers. go.json http://purl.obolibrary.org/obo/GO_0090732 GO:1905534 biolink:BiologicalProcess positive regulation of leucine import across plasma membrane Any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane. go.json activation of L-leucine import into cell|activation of leucine import into cell|positive regulation of L-leucine import into cell|positive regulation of leucine import into cell|up regulation of L-leucine import into cell|up regulation of leucine import into cell|up-regulation of L-leucine import into cell|up-regulation of leucine import into cell|upregulation of L-leucine import into cell|upregulation of leucine import into cell http://purl.obolibrary.org/obo/GO_1905534 GO:1905535 biolink:BiologicalProcess regulation of eukaryotic translation initiation factor 4F complex assembly Any process that modulates the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. go.json regulation of eIF-4F assembly|regulation of eIF4F assembly http://purl.obolibrary.org/obo/GO_1905535 GO:2000990 biolink:BiologicalProcess positive regulation of hemicellulose catabolic process Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process. go.json positive regulation of hemicellulose catabolism http://purl.obolibrary.org/obo/GO_2000990 GO:0090733 biolink:CellularComponent tenascin complex A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R. go.json Tenascin-C|Tenascin-N|Tenascin-R|Tenascin-W|Tenascin-X http://purl.obolibrary.org/obo/GO_0090733 GO:1905536 biolink:BiologicalProcess negative regulation of eukaryotic translation initiation factor 4F complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. go.json down regulation of eIF-4F assembly|down regulation of eIF4F assembly|down regulation of eukaryotic translation initiation factor 4F complex assembly|down-regulation of eIF-4F assembly|down-regulation of eIF4F assembly|down-regulation of eukaryotic translation initiation factor 4F complex assembly|downregulation of eIF-4F assembly|downregulation of eIF4F assembly|downregulation of eukaryotic translation initiation factor 4F complex assembly|inhibition of eIF-4F assembly|inhibition of eIF4F assembly|inhibition of eukaryotic translation initiation factor 4F complex assembly|negative regulation of eIF-4F assembly|negative regulation of eIF4F assembly http://purl.obolibrary.org/obo/GO_1905536 GO:2000991 biolink:BiologicalProcess regulation of galactomannan catabolic process Any process that modulates the frequency, rate or extent of galactomannan catabolic process. go.json http://purl.obolibrary.org/obo/GO_2000991 GO:1905537 biolink:BiologicalProcess positive regulation of eukaryotic translation initiation factor 4F complex assembly Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. go.json activation of eIF-4F assembly|activation of eIF4F assembly|activation of eukaryotic translation initiation factor 4F complex assembly|positive regulation of eIF-4F assembly|positive regulation of eIF4F assembly|up regulation of eIF-4F assembly|up regulation of eIF4F assembly|up regulation of eukaryotic translation initiation factor 4F complex assembly|up-regulation of eIF-4F assembly|up-regulation of eIF4F assembly|up-regulation of eukaryotic translation initiation factor 4F complex assembly|upregulation of eIF-4F assembly|upregulation of eIF4F assembly|upregulation of eukaryotic translation initiation factor 4F complex assembly http://purl.obolibrary.org/obo/GO_1905537 GO:2000992 biolink:BiologicalProcess negative regulation of galactomannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process. go.json http://purl.obolibrary.org/obo/GO_2000992 GO:0090736 biolink:MolecularActivity MATH domain binding Binding to a meprin and TRAF homology (MATH) domain. go.json http://purl.obolibrary.org/obo/GO_0090736 GO:1905538 biolink:MolecularActivity polysome binding Binding to a polysome. go.json polyribosome binding http://purl.obolibrary.org/obo/GO_1905538 GO:2000993 biolink:BiologicalProcess positive regulation of galactomannan catabolic process Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process. go.json http://purl.obolibrary.org/obo/GO_2000993 GO:0090737 biolink:BiologicalProcess telomere maintenance via telomere trimming A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication. go.json http://purl.obolibrary.org/obo/GO_0090737 GO:1905539 biolink:BiologicalProcess regulation of postsynapse to nucleus signaling pathway Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway. go.json regulation of postsynaptic signaling to nucleus http://purl.obolibrary.org/obo/GO_1905539 goslim_synapse GO:2000994 biolink:BiologicalProcess regulation of mannan catabolic process Any process that modulates the frequency, rate or extent of mannan catabolic process. go.json regulation of mannan breakdown|regulation of mannan catabolism|regulation of mannan degradation http://purl.obolibrary.org/obo/GO_2000994 GO:0051122 biolink:BiologicalProcess hepoxilin biosynthetic process The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. go.json hepoxilin anabolism|hepoxilin biosynthesis|hepoxilin formation|hepoxilin synthesis http://purl.obolibrary.org/obo/GO_0051122 GO:0090730 biolink:CellularComponent Las1 complex A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448). go.json Las1-Grc3-Rat1-Rai1 http://purl.obolibrary.org/obo/GO_0090730 GO:0051123 biolink:BiologicalProcess RNA polymerase II preinitiation complex assembly The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA. go.json RNA polymerase II transcription PIC biosynthesis|RNA polymerase II transcription PIC formation|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase II transcriptional preinitiation complex formation http://purl.obolibrary.org/obo/GO_0051123 GO:0090731 biolink:BiologicalProcess cellular response to very-low-density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very-low-density lipoprotein particle stimulus. go.json cellular response to VLDL particle stimulus http://purl.obolibrary.org/obo/GO_0090731 GO:0051120 biolink:MolecularActivity hepoxilin A3 synthase activity Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3. Reactome:R-HSA-2161794|Reactome:R-HSA-8942208 go.json http://purl.obolibrary.org/obo/GO_0051120 GO:0051121 biolink:BiologicalProcess hepoxilin metabolic process The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. go.json hepoxilin metabolism http://purl.obolibrary.org/obo/GO_0051121 GO:0051137 biolink:BiologicalProcess negative regulation of NK T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation. go.json down regulation of NK T cell differentiation|down-regulation of NK T cell differentiation|downregulation of NK T cell differentiation|inhibition of NK T cell differentiation|negative regulation of NK T cell development|negative regulation of NK T lymphocyte differentiation|negative regulation of NK T-cell differentiation|negative regulation of NK T-lymphocyte differentiation|negative regulation of NKT cell differentiation|negative regulation of NT cell differentiation|negative regulation of natural T cell differentiation|negative regulation of natural killer T cell differentiation http://purl.obolibrary.org/obo/GO_0051137 GO:0075104 biolink:BiologicalProcess obsolete positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075104 GO:0051138 biolink:BiologicalProcess positive regulation of NK T cell differentiation Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation. go.json activation of NK T cell differentiation|positive regulation of NK T cell development|positive regulation of NK T lymphocyte differentiation|positive regulation of NK T-cell differentiation|positive regulation of NK T-lymphocyte differentiation|positive regulation of NKT cell differentiation|positive regulation of NT cell differentiation|positive regulation of natural T cell differentiation|positive regulation of natural killer T cell differentiation|stimulation of NK T cell differentiation|up regulation of NK T cell differentiation|up-regulation of NK T cell differentiation|upregulation of NK T cell differentiation http://purl.obolibrary.org/obo/GO_0051138 GO:0075105 biolink:BiologicalProcess obsolete negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075105 GO:0051135 biolink:BiologicalProcess positive regulation of NK T cell activation Any process that activates or increases the frequency, rate or extent of natural killer T cell activation. go.json activation of NK T cell activation|positive regulation of NK T lymphocyte activation|positive regulation of NK T-cell activation|positive regulation of NK T-lymphocyte activation|positive regulation of NKT cell activation|positive regulation of NT cell activation|positive regulation of natural T cell activation|positive regulation of natural killer T cell activation|stimulation of NK T cell activation|up regulation of NK T cell activation|up-regulation of NK T cell activation|upregulation of NK T cell activation http://purl.obolibrary.org/obo/GO_0051135 GO:0075106 biolink:BiologicalProcess obsolete modulation by symbiont of host adenylate cyclase activity OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity|Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity|Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity|Modulation by symbiont of host ATP pyrophosphate-lyase activity|Modulation by symbiont of host adenyl cyclase activity|Modulation by symbiont of host adenylyl cyclase activity|Modulation by symbiont of host adenylylcyclase activity|Modulation by symbiont of host cAMP generating peptide activity True http://purl.obolibrary.org/obo/GO_0075106 GO:0051136 biolink:BiologicalProcess regulation of NK T cell differentiation Any process that modulates the frequency, rate or extent of natural killer T cell differentiation. go.json regulation of NK T cell development|regulation of NK T lymphocyte differentiation|regulation of NK T-cell differentiation|regulation of NK T-lymphocyte differentiation|regulation of NKT cell differentiation|regulation of NT cell differentiation|regulation of natural T cell differentiation|regulation of natural killer T cell differentiation http://purl.obolibrary.org/obo/GO_0051136 GO:0075107 biolink:BiologicalProcess obsolete positive regulation by symbiont of host adenylate cyclase activity OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity|positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity|positive regulation by symbiont of host adenyl cyclase activity|positive regulation by symbiont of host adenylyl cyclase activity|positive regulation by symbiont of host adenylylcyclase activity True http://purl.obolibrary.org/obo/GO_0075107 GO:0075108 biolink:BiologicalProcess obsolete negative regulation by symbiont of host adenylate cyclase activity OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity|Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity|Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity|Negative regulation by symbiont of host ATP pyrophosphate-lyase activity|Negative regulation by symbiont of host adenyl cyclase activity|Negative regulation by symbiont of host adenylyl cyclase activity|Negative regulation by symbiont of host adenylylcyclase activity|Negative regulation by symbiont of host cAMP generating peptide activity True http://purl.obolibrary.org/obo/GO_0075108 GO:0075109 biolink:BiologicalProcess perturbation of host receptor-mediated signal transduction A process in which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075109 GO:0051139 biolink:MolecularActivity metal cation:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). Reactome:R-HSA-435171 go.json metal ion:hydrogen antiporter activity|metal ion:proton antiporter activity http://purl.obolibrary.org/obo/GO_0051139 GO:1905550 biolink:BiologicalProcess regulation of protein localization to endoplasmic reticulum Any process that modulates the frequency, rate or extent of protein localization to endoplasmic reticulum. go.json regulation of protein localisation in endoplasmic reticulum|regulation of protein localization in ER|regulation of protein localization in endoplasmic reticulum http://purl.obolibrary.org/obo/GO_1905550 GO:1905551 biolink:BiologicalProcess negative regulation of protein localization to endoplasmic reticulum Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum. go.json down regulation of protein localisation in endoplasmic reticulum|down regulation of protein localization in ER|down regulation of protein localization in endoplasmic reticulum|down regulation of protein localization to endoplasmic reticulum|down-regulation of protein localisation in endoplasmic reticulum|down-regulation of protein localization in ER|down-regulation of protein localization in endoplasmic reticulum|down-regulation of protein localization to endoplasmic reticulum|downregulation of protein localisation in endoplasmic reticulum|downregulation of protein localization in ER|downregulation of protein localization in endoplasmic reticulum|downregulation of protein localization to endoplasmic reticulum|inhibition of protein localisation in endoplasmic reticulum|inhibition of protein localization in ER|inhibition of protein localization in endoplasmic reticulum|inhibition of protein localization to endoplasmic reticulum|negative regulation of protein localisation in endoplasmic reticulum|negative regulation of protein localization in ER|negative regulation of protein localization in endoplasmic reticulum http://purl.obolibrary.org/obo/GO_1905551 GO:0089710 biolink:MolecularActivity endocytic targeting sequence binding Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits. go.json http://purl.obolibrary.org/obo/GO_0089710 GO:1905552 biolink:BiologicalProcess positive regulation of protein localization to endoplasmic reticulum Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum. go.json activation of protein localisation in endoplasmic reticulum|activation of protein localization in ER|activation of protein localization in endoplasmic reticulum|activation of protein localization to endoplasmic reticulum|positive regulation of protein localisation in endoplasmic reticulum|positive regulation of protein localization in ER|positive regulation of protein localization in endoplasmic reticulum|up regulation of protein localisation in endoplasmic reticulum|up regulation of protein localization in ER|up regulation of protein localization in endoplasmic reticulum|up regulation of protein localization to endoplasmic reticulum|up-regulation of protein localisation in endoplasmic reticulum|up-regulation of protein localization in ER|up-regulation of protein localization in endoplasmic reticulum|up-regulation of protein localization to endoplasmic reticulum|upregulation of protein localisation in endoplasmic reticulum|upregulation of protein localization in ER|upregulation of protein localization in endoplasmic reticulum|upregulation of protein localization to endoplasmic reticulum http://purl.obolibrary.org/obo/GO_1905552 GO:1905553 biolink:BiologicalProcess regulation of blood vessel branching Any process that modulates the frequency, rate or extent of blood vessel branching. go.json regulation of branching involved in blood vessel morphogenesis http://purl.obolibrary.org/obo/GO_1905553 GO:0089711 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0089711 GO:1905543 biolink:CellularComponent interleukin-15 receptor complex A protein complex that binds interleukin-15 (IL-15) and that consists of, at a minimum, an interleukin, an alpha, beta and gamma chain as well as optional additional kinase subunits. The alpha chain is unique to binds IL-15 while it shares the beta chain with the IL-2 receptor and the cytokine receptor common gamma chain with multiple interleukin receptors. go.json IL-15 receptor complex|IL-15-receptor complex|IL15 receptor complex|IL15-receptor complex|interleukin-15-receptor complex http://purl.obolibrary.org/obo/GO_1905543 GO:0090701 biolink:BiologicalProcess specification of plant organ identity The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0090701 GO:0089712 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0089712 GO:0090702 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090702 GO:0089713 biolink:CellularComponent Cbf1-Met4-Met28 complex A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation. go.json http://purl.obolibrary.org/obo/GO_0089713 GO:1905544 biolink:BiologicalProcess L-methionine import across plasma membrane The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-methionine import into cell http://purl.obolibrary.org/obo/GO_1905544 GO:1905545 biolink:BiologicalProcess obsolete negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron. go.json down regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron|down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron|down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron|downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron|inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron|negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron True http://purl.obolibrary.org/obo/GO_1905545 GO:0089714 biolink:MolecularActivity UDP-N-acetyl-D-mannosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+. EC:1.1.1.336|RHEA:25780 go.json http://purl.obolibrary.org/obo/GO_0089714 GO:0089715 biolink:MolecularActivity tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37. MetaCyc:RXN0-7114|RHEA:70027 go.json tRNA (L-threonylcarbamoyladenosine(37)-C(2)) methyltransferase activity|tRNA (L-threonylcarbamoyladenosine37-C2-) methyltransferase activity|tRNA m6t6A37 methyltransferase activity http://purl.obolibrary.org/obo/GO_0089715 GO:1905546 biolink:BiologicalProcess cellular response to phenylpropanoid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylpropanoid stimulus. go.json http://purl.obolibrary.org/obo/GO_1905546 GO:0090700 biolink:BiologicalProcess maintenance of plant organ identity The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0090700 GO:0089716 biolink:CellularComponent Pip2-Oaf1 complex A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins. go.json http://purl.obolibrary.org/obo/GO_0089716 GO:1905547 biolink:BiologicalProcess obsolete regulation of subtelomeric heterochromatin assembly OBSOLETE. Any process that modulates the frequency, rate or extent of subtelomeric heterochromatin assembly. go.json regulation of telomeric heterochromatin assembly|regulation of telomeric heterochromatin formation True http://purl.obolibrary.org/obo/GO_1905547 GO:0090705 biolink:CellularComponent trichome papilla A plant cell papilla that is part of a trichome cell. go.json http://purl.obolibrary.org/obo/GO_0090705 GO:0089717 biolink:CellularComponent obsolete spanning component of membrane OBSOLETE. The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0089717 GO:1905548 biolink:BiologicalProcess obsolete negative regulation of subtelomeric heterochromatin assembly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of subtelomeric heterochromatin assembly. go.json down regulation of telomeric heterochromatin assembly|down regulation of telomeric heterochromatin formation|down-regulation of telomeric heterochromatin assembly|down-regulation of telomeric heterochromatin formation|downregulation of telomeric heterochromatin assembly|downregulation of telomeric heterochromatin formation|inhibition of telomeric heterochromatin assembly|inhibition of telomeric heterochromatin formation|negative regulation of telomeric heterochromatin assembly|negative regulation of telomeric heterochromatin formation True http://purl.obolibrary.org/obo/GO_1905548 GO:0090706 biolink:BiologicalProcess specification of plant organ position The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ. go.json http://purl.obolibrary.org/obo/GO_0090706 GO:1905549 biolink:BiologicalProcess obsolete positive regulation of subtelomeric heterochromatin assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of subtelomeric heterochromatin assembly. go.json activation of telomeric heterochromatin assembly|activation of telomeric heterochromatin formation|positive regulation of telomeric heterochromatin assembly|positive regulation of telomeric heterochromatin formation|up regulation of telomeric heterochromatin assembly|up regulation of telomeric heterochromatin formation|up-regulation of telomeric heterochromatin assembly|up-regulation of telomeric heterochromatin formation|upregulation of telomeric heterochromatin assembly|upregulation of telomeric heterochromatin formation True http://purl.obolibrary.org/obo/GO_1905549 GO:0089718 biolink:BiologicalProcess amino acid import across plasma membrane The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. go.json L-amino acid import|L-amino acid uptake|amino acid import into cell|amino acid transmembrane import http://purl.obolibrary.org/obo/GO_0089718 GO:0090703 biolink:BiologicalProcess obsolete triplex DNA unwinding OBSOLETE. The process by which a three-stranded D-loop DNA is unwound or 'melted'. go.json True http://purl.obolibrary.org/obo/GO_0090703 GO:0089719 biolink:MolecularActivity RHG protein domain binding Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif). go.json RHG domain binding|iap binding domain binding|inhibitor of apoptosis binding domain binding|reaper hid grim domain binding http://purl.obolibrary.org/obo/GO_0089719 GO:0090704 biolink:MolecularActivity nicotinate-O-glucosyltransferase activity Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP. go.json http://purl.obolibrary.org/obo/GO_0090704 GO:0051130 biolink:BiologicalProcess positive regulation of cellular component organization Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. go.json activation of cell organization|positive regulation of cell organisation|positive regulation of cellular component organization and biogenesis|stimulation of cell organization|up regulation of cell organization|up-regulation of cell organization|upregulation of cell organization http://purl.obolibrary.org/obo/GO_0051130 GO:0051133 biolink:BiologicalProcess regulation of NK T cell activation Any process that modulates the frequency, rate or extent of natural killer T cell activation. go.json regulation of NK T lymphocyte activation|regulation of NK T-cell activation|regulation of NK T-lymphocyte activation|regulation of NKT cell activation|regulation of NT cell activation|regulation of natural T cell activation|regulation of natural killer T cell activation http://purl.obolibrary.org/obo/GO_0051133 GO:0075100 biolink:BiologicalProcess obsolete positive regulation by host of symbiont protein kinase-mediated signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075100 GO:0051134 biolink:BiologicalProcess negative regulation of NK T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation. go.json down regulation of NK T cell activation|down-regulation of NK T cell activation|downregulation of NK T cell activation|inhibition of NK T cell activation|negative regulation of NK T lymphocyte activation|negative regulation of NK T-cell activation|negative regulation of NK T-lymphocyte activation|negative regulation of NKT cell activation|negative regulation of NT cell activation|negative regulation of natural T cell activation|negative regulation of natural killer T cell activation http://purl.obolibrary.org/obo/GO_0051134 GO:0075101 biolink:BiologicalProcess obsolete negative regulation by host of symbiont protein kinase-mediated signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075101 GO:0051131 biolink:BiologicalProcess chaperone-mediated protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. go.json cellular chaperone-mediated protein complex assembly|chaperone activity|protein complex assembly, multichaperone pathway http://purl.obolibrary.org/obo/GO_0051131 GO:0075102 biolink:BiologicalProcess obsolete negative regulation by host of symbiont MAP kinase-mediated signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075102 GO:0051132 biolink:BiologicalProcess NK T cell activation The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json NK T lymphocyte activation|NK T-cell activation|NK T-lymphocyte activation|NKT cell activation|NT cell activation|natural T cell activation|natural killer T cell activation http://purl.obolibrary.org/obo/GO_0051132 GO:0075103 biolink:BiologicalProcess obsolete modulation by host of symbiont calcium or calmodulin-mediated signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075103 GO:0051148 biolink:BiologicalProcess negative regulation of muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. go.json down regulation of muscle cell differentiation|down-regulation of muscle cell differentiation|downregulation of muscle cell differentiation|inhibition of muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051148 GO:0051149 biolink:BiologicalProcess positive regulation of muscle cell differentiation Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. go.json activation of muscle cell differentiation|stimulation of muscle cell differentiation|up regulation of muscle cell differentiation|up-regulation of muscle cell differentiation|upregulation of muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051149 GO:0051146 biolink:BiologicalProcess striated muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. go.json voluntary muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051146 GO:0051147 biolink:BiologicalProcess regulation of muscle cell differentiation Any process that modulates the frequency, rate or extent of muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0051147 GO:0090709 biolink:BiologicalProcess regulation of timing of plant organ formation Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development. go.json http://purl.obolibrary.org/obo/GO_0090709 GO:0090707 biolink:BiologicalProcess establishment of plant organ orientation The process that determines the orientation of a plant organ or tissue with reference to an axis. go.json http://purl.obolibrary.org/obo/GO_0090707 GO:1905560 biolink:BiologicalProcess negative regulation of kinetochore assembly Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly. go.json down regulation of centromere and kinetochore complex maturation|down regulation of centromere/kinetochore complex maturation|down regulation of chromosome-kinetochore attachment|down regulation of kinetochore assembly|down regulation of kinetochore biogenesis|down regulation of kinetochore formation|down-regulation of centromere and kinetochore complex maturation|down-regulation of centromere/kinetochore complex maturation|down-regulation of chromosome-kinetochore attachment|down-regulation of kinetochore assembly|down-regulation of kinetochore formation|downregulation of centromere and kinetochore complex maturation|downregulation of centromere/kinetochore complex maturation|downregulation of chromosome-kinetochore attachment|downregulation of kinetochore assembly|downregulation of kinetochore formation|inhibition of centromere and kinetochore complex maturation|inhibition of centromere/kinetochore complex maturation|inhibition of chromosome-kinetochore attachment|inhibition of kinetochore assembly|inhibition of kinetochore formation|negative regulation of NMS complex assembly|negative regulation of centromere and kinetochore complex maturation|negative regulation of centromere/kinetochore complex maturation|negative regulation of chromosome-kinetochore attachment|negative regulation of kinetochore formation http://purl.obolibrary.org/obo/GO_1905560 GO:0090708 biolink:BiologicalProcess specification of plant organ axis polarity The process in which the polarity of a plant organ axis is specified. go.json http://purl.obolibrary.org/obo/GO_0090708 GO:1905561 biolink:BiologicalProcess positive regulation of kinetochore assembly Any process that activates or increases the frequency, rate or extent of kinetochore assembly. go.json activation of centromere and kinetochore complex maturation|activation of centromere/kinetochore complex maturation|activation of chromosome-kinetochore attachment|activation of kinetochore assembly|activation of kinetochore formation|positive regulation of NMS complex assembly|positive regulation of centromere and kinetochore complex maturation|positive regulation of centromere/kinetochore complex maturation|positive regulation of chromosome-kinetochore attachment|positive regulation of kinetochore formation|up regulation of centromere and kinetochore complex maturation|up regulation of centromere/kinetochore complex maturation|up regulation of chromosome-kinetochore attachment|up regulation of kinetochore assembly|up regulation of kinetochore formation|up-regulation of centromere and kinetochore complex maturation|up-regulation of centromere/kinetochore complex maturation|up-regulation of chromosome-kinetochore attachment|up-regulation of kinetochore assembly|up-regulation of kinetochore formation|upregulation of centromere and kinetochore complex maturation|upregulation of centromere/kinetochore complex maturation|upregulation of chromosome-kinetochore attachment|upregulation of kinetochore assembly|upregulation of kinetochore formation http://purl.obolibrary.org/obo/GO_1905561 GO:0089720 biolink:MolecularActivity caspase binding Binding to a caspase family protein. go.json http://purl.obolibrary.org/obo/GO_0089720 GO:1905562 biolink:BiologicalProcess regulation of vascular endothelial cell proliferation Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_1905562 GO:0089721 biolink:MolecularActivity phosphoenolpyruvate transmembrane transporter activity Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0089721 GO:1905563 biolink:BiologicalProcess negative regulation of vascular endothelial cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. go.json down regulation of vascular endothelial cell proliferation|down-regulation of vascular endothelial cell proliferation|downregulation of vascular endothelial cell proliferation|inhibition of vascular endothelial cell proliferation http://purl.obolibrary.org/obo/GO_1905563 GO:0089722 biolink:BiologicalProcess phosphoenolpyruvate transmembrane transport The directed movement of phosphoenolpytuvate across a membrane. go.json http://purl.obolibrary.org/obo/GO_0089722 GO:1905564 biolink:BiologicalProcess positive regulation of vascular endothelial cell proliferation Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. go.json activation of vascular endothelial cell proliferation|up regulation of vascular endothelial cell proliferation|up-regulation of vascular endothelial cell proliferation|upregulation of vascular endothelial cell proliferation http://purl.obolibrary.org/obo/GO_1905564 GO:1905554 biolink:BiologicalProcess negative regulation of vessel branching Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. go.json down regulation of branching involved in blood vessel morphogenesis|down regulation of patterning of blood vessels|down-regulation of branching involved in blood vessel morphogenesis|down-regulation of patterning of blood vessels|downregulation of branching involved in blood vessel morphogenesis|downregulation of patterning of blood vessels|inhibition of branching involved in blood vessel morphogenesis|inhibition of patterning of blood vessels|negative regulation of branching involved in blood vessel morphogenesis http://purl.obolibrary.org/obo/GO_1905554 GO:0090712 biolink:CellularComponent basal pole of outer hair cell The end of the outer hair cell which receives and transmits neural signals. go.json http://purl.obolibrary.org/obo/GO_0090712 GO:0090713 biolink:BiologicalProcess immunological memory process Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory. go.json http://purl.obolibrary.org/obo/GO_0090713 GO:1905555 biolink:BiologicalProcess positive regulation of blood vessel branching Any process that activates or increases the frequency, rate or extent of blood vessel branching. go.json activation of branching involved in blood vessel morphogenesis|activation of patterning of blood vessels|positive regulation of branching involved in blood vessel morphogenesis|up regulation of branching involved in blood vessel morphogenesis|up regulation of patterning of blood vessels|up-regulation of branching involved in blood vessel morphogenesis|up-regulation of patterning of blood vessels|upregulation of branching involved in blood vessel morphogenesis|upregulation of patterning of blood vessels http://purl.obolibrary.org/obo/GO_1905555 GO:1905556 biolink:BiologicalProcess ciliary vesicle assembly The aggregation, arrangement and bonding together of a set of components to form a ciliary vesicle. Multiple smaller vesicles dock to the transitional fibers on a mature basal body and then fuse together to form a larger single vesicle. This then fuses with the plasma membrane and forms the ciliary membrane. go.json CV assembly|CV formation|ciliary vesicle formation|primary ciliary vesicle assembly|primary ciliary vesicle formation http://purl.obolibrary.org/obo/GO_1905556 GO:0090710 biolink:MolecularActivity phosphomevalonate decarboxylase activity Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate. go.json http://purl.obolibrary.org/obo/GO_0090710 GO:1905557 biolink:BiologicalProcess regulation of mitotic nuclear envelope disassembly Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. go.json regulation of mitotic nuclear envelope breakdown|regulation of mitotic nuclear envelope catabolism|regulation of mitotic nuclear envelope degradation http://purl.obolibrary.org/obo/GO_1905557 GO:0090711 biolink:MolecularActivity FMN hydrolase activity Catalysis of the reaction: FMN + H2O = riboflavin + phosphate. go.json http://purl.obolibrary.org/obo/GO_0090711 GO:1905558 biolink:BiologicalProcess negative regulation of mitotic nuclear envelope disassembly Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. go.json down regulation of mitotic nuclear envelope breakdown|down regulation of mitotic nuclear envelope catabolism|down regulation of mitotic nuclear envelope degradation|down regulation of mitotic nuclear envelope disassembly|down-regulation of mitotic nuclear envelope breakdown|down-regulation of mitotic nuclear envelope catabolism|down-regulation of mitotic nuclear envelope degradation|down-regulation of mitotic nuclear envelope disassembly|downregulation of mitotic nuclear envelope breakdown|downregulation of mitotic nuclear envelope catabolism|downregulation of mitotic nuclear envelope degradation|downregulation of mitotic nuclear envelope disassembly|inhibition of mitotic nuclear envelope breakdown|inhibition of mitotic nuclear envelope catabolism|inhibition of mitotic nuclear envelope degradation|inhibition of mitotic nuclear envelope disassembly|negative regulation of mitotic nuclear envelope breakdown|negative regulation of mitotic nuclear envelope catabolism|negative regulation of mitotic nuclear envelope degradation http://purl.obolibrary.org/obo/GO_1905558 GO:0090716 biolink:BiologicalProcess adaptive immune memory response An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. go.json http://purl.obolibrary.org/obo/GO_0090716 GO:0090717 biolink:BiologicalProcess adaptive immune memory response involving T cells and B cells An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. go.json http://purl.obolibrary.org/obo/GO_0090717 GO:1905559 biolink:BiologicalProcess positive regulation of mitotic nuclear envelope disassembly Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. go.json activation of mitotic nuclear envelope breakdown|activation of mitotic nuclear envelope catabolism|activation of mitotic nuclear envelope degradation|activation of mitotic nuclear envelope disassembly|positive regulation of mitotic nuclear envelope breakdown|positive regulation of mitotic nuclear envelope catabolism|positive regulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope breakdown|up regulation of mitotic nuclear envelope catabolism|up regulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope disassembly|up-regulation of mitotic nuclear envelope breakdown|up-regulation of mitotic nuclear envelope catabolism|up-regulation of mitotic nuclear envelope degradation|up-regulation of mitotic nuclear envelope disassembly|upregulation of mitotic nuclear envelope breakdown|upregulation of mitotic nuclear envelope catabolism|upregulation of mitotic nuclear envelope degradation|upregulation of mitotic nuclear envelope disassembly http://purl.obolibrary.org/obo/GO_1905559 GO:0090714 biolink:BiologicalProcess innate immunity memory response An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus. go.json http://purl.obolibrary.org/obo/GO_0090714 GO:0090715 biolink:BiologicalProcess immunological memory formation process Any immunological memory process that can contribute to the formation of immunological memory. go.json http://purl.obolibrary.org/obo/GO_0090715 GO:0051140 biolink:BiologicalProcess regulation of NK T cell proliferation Any process that modulates the frequency, rate or extent of natural killer T cell proliferation. go.json regulation of NK T lymphocyte proliferation|regulation of NK T-cell proliferation|regulation of NK T-lymphocyte proliferation|regulation of NKT cell proliferation|regulation of NT cell proliferation|regulation of natural T cell proliferation|regulation of natural killer T cell proliferation http://purl.obolibrary.org/obo/GO_0051140 GO:0051141 biolink:BiologicalProcess negative regulation of NK T cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation. go.json down regulation of NK T cell proliferation|down-regulation of NK T cell proliferation|downregulation of NK T cell proliferation|inhibition of NK T cell proliferation|negative regulation of NK T lymphocyte proliferation|negative regulation of NK T-cell proliferation|negative regulation of NK T-lymphocyte proliferation|negative regulation of NKT cell proliferation|negative regulation of NT cell proliferation|negative regulation of natural T cell proliferation|negative regulation of natural killer T cell proliferation http://purl.obolibrary.org/obo/GO_0051141 GO:0051144 biolink:BiologicalProcess propanediol catabolic process The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH. go.json 1,2-dihydroxypropane catabolic process|1,2-dihydroxypropane catabolism|propanediol breakdown|propanediol catabolism|propanediol degradation|propylene glycol catabolic process|propylene glycol catabolism http://purl.obolibrary.org/obo/GO_0051144 GO:0051145 biolink:BiologicalProcess smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. go.json nonstriated muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051145 GO:0051142 biolink:BiologicalProcess positive regulation of NK T cell proliferation Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation. go.json activation of NK T cell proliferation|positive regulation of NK T lymphocyte proliferation|positive regulation of NK T-cell proliferation|positive regulation of NK T-lymphocyte proliferation|positive regulation of NKT cell proliferation|positive regulation of NT cell proliferation|positive regulation of natural T cell proliferation|positive regulation of natural killer T cell proliferation|stimulation of NK T cell proliferation|up regulation of NK T cell proliferation|up-regulation of NK T cell proliferation|upregulation of NK T cell proliferation http://purl.obolibrary.org/obo/GO_0051142 GO:0051143 biolink:BiologicalProcess propanediol metabolic process The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items. go.json 1,2-dihydroxypropane metabolic process|1,2-dihydroxypropane metabolism|propanediol metabolism|propylene glycol metabolic process|propylene glycol metabolism http://purl.obolibrary.org/obo/GO_0051143 GO:2000948 biolink:BiologicalProcess regulation of xyloglucan metabolic process Any process that modulates the frequency, rate or extent of xyloglucan metabolic process. go.json regulation of xyloglucan metabolism http://purl.obolibrary.org/obo/GO_2000948 GO:0051159 biolink:BiologicalProcess D-arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. go.json D-arabitol breakdown|D-arabitol catabolism|D-arabitol degradation http://purl.obolibrary.org/obo/GO_0051159 GO:0075126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075126 GO:2000949 biolink:BiologicalProcess negative regulation of xyloglucan metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan metabolic process. go.json negative regulation of xyloglucan metabolism http://purl.obolibrary.org/obo/GO_2000949 GO:0075127 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075127 GO:0051157 biolink:BiologicalProcess arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. go.json arabitol breakdown|arabitol catabolism|arabitol degradation|arabitol utilization http://purl.obolibrary.org/obo/GO_0051157 GO:0110058 biolink:BiologicalProcess positive regulation of blood vessel endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0110058 GO:0075128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075128 GO:0110059 biolink:BiologicalProcess negative regulation of blood vessel endothelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0110059 GO:0051158 biolink:BiologicalProcess L-arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. go.json L-arabitol breakdown|L-arabitol catabolism|L-arabitol degradation http://purl.obolibrary.org/obo/GO_0051158 GO:0075129 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075129 GO:0110056 biolink:BiologicalProcess positive regulation of actin filament annealing Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. go.json http://purl.obolibrary.org/obo/GO_0110056 GO:0110057 biolink:BiologicalProcess regulation of blood vessel endothelial cell differentiation Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0110057 GO:0110054 biolink:BiologicalProcess regulation of actin filament annealing Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. go.json http://purl.obolibrary.org/obo/GO_0110054 GO:0110055 biolink:BiologicalProcess negative regulation of actin filament annealing Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. go.json http://purl.obolibrary.org/obo/GO_0110055 GO:2000940 biolink:BiologicalProcess negative regulation of plant-type cell wall cellulose catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose catabolic process. go.json negative regulation of plant-type cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_2000940 GO:0110052 biolink:BiologicalProcess toxic metabolite repair A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites. go.json http://purl.obolibrary.org/obo/GO_0110052 GO:0110053 biolink:BiologicalProcess regulation of actin filament organization Any process that modulates the frequency, rate or extent of actin filament organization. go.json http://purl.obolibrary.org/obo/GO_0110053 GO:2000941 biolink:BiologicalProcess positive regulation of plant-type cell wall cellulose catabolic process Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process. go.json positive regulation of plant-type cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_2000941 GO:1905570 biolink:BiologicalProcess positive regulation of ferrichrome biosynthetic process Any process that activates or increases the frequency, rate or extent of ferrichrome biosynthetic process. go.json activation of ferrichrome anabolism|activation of ferrichrome biosynthesis|activation of ferrichrome biosynthetic process|activation of ferrichrome biosynthetic process, peptide formation|activation of ferrichrome biosynthetic process, peptide modification|activation of ferrichrome formation|activation of ferrichrome synthesis|positive regulation of ferrichrome anabolism|positive regulation of ferrichrome biosynthesis|positive regulation of ferrichrome biosynthetic process, peptide formation|positive regulation of ferrichrome biosynthetic process, peptide modification|positive regulation of ferrichrome formation|positive regulation of ferrichrome synthesis|up regulation of ferrichrome anabolism|up regulation of ferrichrome biosynthesis|up regulation of ferrichrome biosynthetic process|up regulation of ferrichrome biosynthetic process, peptide formation|up regulation of ferrichrome biosynthetic process, peptide modification|up regulation of ferrichrome formation|up regulation of ferrichrome synthesis|up-regulation of ferrichrome anabolism|up-regulation of ferrichrome biosynthesis|up-regulation of ferrichrome biosynthetic process|up-regulation of ferrichrome biosynthetic process, peptide formation|up-regulation of ferrichrome biosynthetic process, peptide modification|up-regulation of ferrichrome formation|up-regulation of ferrichrome synthesis|upregulation of ferrichrome anabolism|upregulation of ferrichrome biosynthesis|upregulation of ferrichrome biosynthetic process|upregulation of ferrichrome biosynthetic process, peptide formation|upregulation of ferrichrome biosynthetic process, peptide modification|upregulation of ferrichrome formation|upregulation of ferrichrome synthesis http://purl.obolibrary.org/obo/GO_1905570 GO:0110050 biolink:MolecularActivity deaminated glutathione amidase activity Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine. EC:3.5.1.128|RHEA:54532 go.json http://purl.obolibrary.org/obo/GO_0110050 GO:2000942 biolink:BiologicalProcess regulation of amylopectin metabolic process Any process that modulates the frequency, rate or extent of amylopectin metabolic process. go.json regulation of Amylopectin metabolism http://purl.obolibrary.org/obo/GO_2000942 GO:2000943 biolink:BiologicalProcess negative regulation of amylopectin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process. go.json negative regulation of Amylopectin metabolism http://purl.obolibrary.org/obo/GO_2000943 GO:1905571 biolink:CellularComponent interleukin-10 receptor complex A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors. go.json IL-10 receptor complex|IL-10-receptor complex|IL10 receptor complex|interleukin-10-receptor complex http://purl.obolibrary.org/obo/GO_1905571 GO:0110051 biolink:BiologicalProcess metabolite repair A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites. go.json http://purl.obolibrary.org/obo/GO_0110051 GO:1905572 biolink:BiologicalProcess ganglioside GM1 transport to membrane The directed movement of ganglioside GM1 to membrane. go.json http://purl.obolibrary.org/obo/GO_1905572 GO:2000944 biolink:BiologicalProcess positive regulation of amylopectin metabolic process Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process. go.json positive regulation of Amylopectin metabolism http://purl.obolibrary.org/obo/GO_2000944 GO:2000945 biolink:BiologicalProcess regulation of amylopectin catabolic process Any process that modulates the frequency, rate or extent of amylopectin catabolic process. go.json regulation of Amylopectin catabolism http://purl.obolibrary.org/obo/GO_2000945 GO:1905573 biolink:MolecularActivity ganglioside GM1 binding Binding to ganglioside GM1. go.json http://purl.obolibrary.org/obo/GO_1905573 GO:2000946 biolink:BiologicalProcess negative regulation of amylopectin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process. go.json negative regulation of Amylopectin catabolism http://purl.obolibrary.org/obo/GO_2000946 GO:1905574 biolink:MolecularActivity ganglioside GM2 binding Binding to ganglioside GM2. go.json http://purl.obolibrary.org/obo/GO_1905574 GO:2000947 biolink:BiologicalProcess positive regulation of amylopectin catabolic process Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process. go.json positive regulation of Amylopectin catabolism http://purl.obolibrary.org/obo/GO_2000947 GO:1905575 biolink:MolecularActivity ganglioside GM3 binding Binding to ganglioside GM3. go.json http://purl.obolibrary.org/obo/GO_1905575 GO:1905565 biolink:BiologicalProcess obsolete regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport OBSOLETE. Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport. go.json regulation of receptor-mediated endocytosis of LDL|regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport True http://purl.obolibrary.org/obo/GO_1905565 GO:1905566 biolink:BiologicalProcess obsolete negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport. go.json down regulation of receptor-mediated endocytosis of LDL|down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|down-regulation of receptor-mediated endocytosis of LDL|down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|downregulation of receptor-mediated endocytosis of LDL|downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|inhibition of receptor-mediated endocytosis of LDL|inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|negative regulation of receptor-mediated endocytosis of LDL|negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport True http://purl.obolibrary.org/obo/GO_1905566 GO:1905567 biolink:BiologicalProcess obsolete positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport OBSOLETE. Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport. go.json activation of receptor-mediated endocytosis of LDL|activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|positive regulation of receptor-mediated endocytosis of LDL|positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up regulation of receptor-mediated endocytosis of LDL|up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|up-regulation of receptor-mediated endocytosis of LDL|up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|upregulation of receptor-mediated endocytosis of LDL|upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport True http://purl.obolibrary.org/obo/GO_1905567 GO:1905568 biolink:BiologicalProcess regulation of ferrichrome biosynthetic process Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process. go.json regulation of ferrichrome anabolism|regulation of ferrichrome biosynthesis|regulation of ferrichrome biosynthetic process, peptide formation|regulation of ferrichrome biosynthetic process, peptide modification|regulation of ferrichrome formation|regulation of ferrichrome synthesis http://purl.obolibrary.org/obo/GO_1905568 GO:1905569 biolink:BiologicalProcess negative regulation of ferrichrome biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process. go.json down regulation of ferrichrome anabolism|down regulation of ferrichrome biosynthesis|down regulation of ferrichrome biosynthetic process|down regulation of ferrichrome biosynthetic process, peptide formation|down regulation of ferrichrome biosynthetic process, peptide modification|down regulation of ferrichrome formation|down regulation of ferrichrome synthesis|down-regulation of ferrichrome anabolism|down-regulation of ferrichrome biosynthesis|down-regulation of ferrichrome biosynthetic process|down-regulation of ferrichrome biosynthetic process, peptide formation|down-regulation of ferrichrome biosynthetic process, peptide modification|down-regulation of ferrichrome formation|down-regulation of ferrichrome synthesis|downregulation of ferrichrome anabolism|downregulation of ferrichrome biosynthesis|downregulation of ferrichrome biosynthetic process|downregulation of ferrichrome biosynthetic process, peptide formation|downregulation of ferrichrome biosynthetic process, peptide modification|downregulation of ferrichrome formation|downregulation of ferrichrome synthesis|inhibition of ferrichrome anabolism|inhibition of ferrichrome biosynthesis|inhibition of ferrichrome biosynthetic process|inhibition of ferrichrome biosynthetic process, peptide formation|inhibition of ferrichrome biosynthetic process, peptide modification|inhibition of ferrichrome formation|inhibition of ferrichrome synthesis|negative regulation of ferrichrome anabolism|negative regulation of ferrichrome biosynthesis|negative regulation of ferrichrome biosynthetic process, peptide formation|negative regulation of ferrichrome biosynthetic process, peptide modification|negative regulation of ferrichrome formation|negative regulation of ferrichrome synthesis http://purl.obolibrary.org/obo/GO_1905569 GO:0051151 biolink:BiologicalProcess negative regulation of smooth muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. go.json down regulation of smooth muscle cell differentiation|down-regulation of smooth muscle cell differentiation|downregulation of smooth muscle cell differentiation|inhibition of smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051151 GO:0051152 biolink:BiologicalProcess positive regulation of smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. go.json activation of smooth muscle cell differentiation|stimulation of smooth muscle cell differentiation|up regulation of smooth muscle cell differentiation|up-regulation of smooth muscle cell differentiation|upregulation of smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051152 GO:0075120 biolink:BiologicalProcess symbiont-mediated suppression of host G protein-coupled receptor signal transduction A process in which a symbiont interferes with, inhibits or disrupts a G protein-coupled receptor signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host G protein-coupled receptor signal transduction|negative regulation by symbiont of host G protein-coupled receptor signal transduction|negative regulation by symbiont of host G-protein coupled receptor protein signal transduction|negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit|negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit|negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit|suppression by symbiont of host G protein-coupled receptor signal transduction http://purl.obolibrary.org/obo/GO_0075120 GO:0051150 biolink:BiologicalProcess regulation of smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0051150 GO:0075121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075121 GO:0051155 biolink:BiologicalProcess positive regulation of striated muscle cell differentiation Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. go.json activation of striated muscle cell differentiation|stimulation of striated muscle cell differentiation|up regulation of striated muscle cell differentiation|up-regulation of striated muscle cell differentiation|upregulation of striated muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051155 GO:0075122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075122 GO:0051156 biolink:BiologicalProcess glucose 6-phosphate metabolic process The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. go.json glucose 6-phosphate metabolism|glucose 6-phosphate utilization http://purl.obolibrary.org/obo/GO_0051156 GO:0075123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075123 GO:0051153 biolink:BiologicalProcess regulation of striated muscle cell differentiation Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0051153 GO:0075124 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075124 GO:0051154 biolink:BiologicalProcess negative regulation of striated muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. go.json down regulation of striated muscle cell differentiation|down-regulation of striated muscle cell differentiation|downregulation of striated muscle cell differentiation|inhibition of striated muscle cell differentiation http://purl.obolibrary.org/obo/GO_0051154 GO:0075125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075125 GO:2000959 biolink:BiologicalProcess positive regulation of cyclodextrin catabolic process Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process. go.json positive regulation of cyclodextrin catabolism http://purl.obolibrary.org/obo/GO_2000959 GO:0099104 biolink:MolecularActivity potassium channel activator activity Binds to and increases the activity of a potassium channel, resulting in its opening. go.json http://purl.obolibrary.org/obo/GO_0099104 GO:0075115 biolink:BiologicalProcess obsolete modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host transmembrane receptor-mediated cAMP signaling True http://purl.obolibrary.org/obo/GO_0075115 GO:0099105 biolink:BiologicalProcess ion channel modulating, G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel. go.json ion channel modulating, G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0099105 GO:0075116 biolink:BiologicalProcess obsolete induction by symbiont of host transmembrane receptor-mediated cAMP signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction|positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction|positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling|promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction|stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction|upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction True http://purl.obolibrary.org/obo/GO_0075116 GO:0051168 biolink:BiologicalProcess nuclear export The directed movement of substances out of the nucleus. go.json export from nucleus|nucleus export|substance nuclear export http://purl.obolibrary.org/obo/GO_0051168 GO:0099102 biolink:MolecularActivity G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential. go.json http://purl.obolibrary.org/obo/GO_0099102 goslim_synapse GO:0110069 biolink:BiologicalProcess syncytial embryo cellularization The separation of a syncytial embryo into individual cells. go.json http://purl.obolibrary.org/obo/GO_0110069 GO:0075117 biolink:BiologicalProcess obsolete suppression by symbiont of host transmembrane receptor-mediated cAMP signal transduction OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction|inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction|negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling True http://purl.obolibrary.org/obo/GO_0075117 GO:0051169 biolink:BiologicalProcess nuclear transport The directed movement of substances into, out of, or within the nucleus. Wikipedia:Nuclear_transport go.json nucleus transport http://purl.obolibrary.org/obo/GO_0051169 goslim_yeast GO:0075118 biolink:BiologicalProcess perturbation of host G protein-coupled receptor signal transduction pathway Any process in which the symbiont alters a host G protein-coupled receptor signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host G protein-coupled receptor signal transduction|modulation by symbiont of host G-protein coupled receptor protein signal transduction|modulation by symbiont of host signal transduction mediated by G-protein alpha subunit|modulation by symbiont of host signal transduction mediated by G-protein beta subunit|modulation by symbiont of host signal transduction mediated by G-protein gamma subunit http://purl.obolibrary.org/obo/GO_0075118 GO:0099103 biolink:MolecularActivity channel activator activity Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. go.json channel gating activity http://purl.obolibrary.org/obo/GO_0099103 GO:0075119 biolink:BiologicalProcess obsolete induction by symbiont of host G protein-coupled receptor signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host G protein-coupled receptor signal transduction|positive regulation by symbiont of host G-protein coupled receptor protein signal transduction|positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit|positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit|positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit True http://purl.obolibrary.org/obo/GO_0075119 GO:0110067 biolink:CellularComponent ammonium transmembrane transporter complex High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other. go.json AMT1 complex http://purl.obolibrary.org/obo/GO_0110067 GO:0099100 biolink:MolecularActivity G-protein gated monoatomic cation channel activity A cation channel activity that is gated by binding of a G-protein beta-gamma dimer. go.json G-protein gated cation channel activity http://purl.obolibrary.org/obo/GO_0099100 GO:0099101 biolink:MolecularActivity G-protein gated potassium channel activity A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer. go.json http://purl.obolibrary.org/obo/GO_0099101 GO:0110068 biolink:MolecularActivity glucosylglycerate phosphorylase activity Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate. go.json http://purl.obolibrary.org/obo/GO_0110068 GO:0110065 biolink:BiologicalProcess regulation of interphase mitotic telomere clustering Any process that modulates the frequency, rate or extent of mitotic telomere clustering during interphase. go.json regulation of mitotic telomere clustering during interphase http://purl.obolibrary.org/obo/GO_0110065 GO:0110066 biolink:BiologicalProcess negative regulation of interphase mitotic telomere clustering Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase. go.json negative regulation of mitotic telomere clustering during interphase|telomere dispersion during interphase http://purl.obolibrary.org/obo/GO_0110066 GO:2000951 biolink:BiologicalProcess regulation of xyloglucan catabolic process Any process that modulates the frequency, rate or extent of xyloglucan catabolic process. go.json regulation of xyloglucan catabolism http://purl.obolibrary.org/obo/GO_2000951 GO:0110063 biolink:BiologicalProcess positive regulation of angiotensin-activated signaling pathway Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0110063 GO:1905580 biolink:BiologicalProcess positive regulation of ERBB3 signaling pathway Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway. go.json activation of ERBB3 signaling pathway|activation of ERBB3 signalling pathway|activation of HER3 signaling pathway|activation of receptor tyrosine-protein kinase erbB-3 signaling pathway|positive regulation of ERBB3 signalling pathway|positive regulation of HER3 signaling pathway|positive regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway|up regulation of ERBB3 signaling pathway|up regulation of ERBB3 signalling pathway|up regulation of HER3 signaling pathway|up regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway|up-regulation of ERBB3 signaling pathway|up-regulation of ERBB3 signalling pathway|up-regulation of HER3 signaling pathway|up-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway|upregulation of ERBB3 signaling pathway|upregulation of ERBB3 signalling pathway|upregulation of HER3 signaling pathway|upregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway http://purl.obolibrary.org/obo/GO_1905580 GO:2000952 biolink:BiologicalProcess negative regulation of xyloglucan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan catabolic process. go.json negative regulation of xyloglucan catabolism http://purl.obolibrary.org/obo/GO_2000952 GO:0110064 biolink:BiologicalProcess lncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length. go.json lncRNA breakdown|lncRNA catabolism|lncRNA degradation http://purl.obolibrary.org/obo/GO_0110064 GO:1905581 biolink:BiologicalProcess positive regulation of low-density lipoprotein particle clearance Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance. go.json activation of LDL clearance|activation of low-density lipoprotein particle clearance|positive regulation of LDL clearance|up regulation of LDL clearance|up regulation of low-density lipoprotein particle clearance|up-regulation of LDL clearance|up-regulation of low-density lipoprotein particle clearance|upregulation of LDL clearance|upregulation of low-density lipoprotein particle clearance http://purl.obolibrary.org/obo/GO_1905581 GO:0110061 biolink:BiologicalProcess regulation of angiotensin-activated signaling pathway Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0110061 GO:2000953 biolink:BiologicalProcess positive regulation of xyloglucan catabolic process Any process that activates or increases the frequency, rate or extent of xyloglucan catabolic process. go.json positive regulation of xyloglucan catabolism http://purl.obolibrary.org/obo/GO_2000953 GO:0110062 biolink:BiologicalProcess negative regulation of angiotensin-activated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0110062 GO:1905582 biolink:BiologicalProcess response to mannose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus. go.json http://purl.obolibrary.org/obo/GO_1905582 GO:2000954 biolink:BiologicalProcess regulation of cyclodextrin metabolic process Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process. go.json regulation of cyclodextrin metabolism http://purl.obolibrary.org/obo/GO_2000954 GO:1905583 biolink:BiologicalProcess cellular response to mannose Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus. go.json http://purl.obolibrary.org/obo/GO_1905583 GO:2000955 biolink:BiologicalProcess negative regulation of cyclodextrin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin metabolic process. go.json negative regulation of cyclodextrin metabolism http://purl.obolibrary.org/obo/GO_2000955 GO:1905584 biolink:BiologicalProcess outer hair cell apoptotic process Any apoptotic process in an outer hair cell. go.json cochlear outer hair cell apoptosis|cochlear outer hair cell apoptotic process|outer hair cell apoptosis http://purl.obolibrary.org/obo/GO_1905584 GO:2000956 biolink:BiologicalProcess positive regulation of cyclodextrin metabolic process Any process that activates or increases the frequency, rate or extent of cyclodextrin metabolic process. go.json positive regulation of cyclodextrin metabolism http://purl.obolibrary.org/obo/GO_2000956 GO:1905585 biolink:BiologicalProcess regulation of outer hair cell apoptotic process Any process that modulates the frequency, rate or extent of outer hair cell apoptotic process. go.json regulation of cochlear outer hair cell apoptosis|regulation of cochlear outer hair cell apoptotic process|regulation of outer hair cell apoptosis http://purl.obolibrary.org/obo/GO_1905585 GO:2000957 biolink:BiologicalProcess regulation of cyclodextrin catabolic process Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process. go.json regulation of cyclodextrin catabolism http://purl.obolibrary.org/obo/GO_2000957 GO:1905586 biolink:BiologicalProcess negative regulation of outer hair cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of outer hair cell apoptotic process. go.json down regulation of cochlear outer hair cell apoptosis|down regulation of cochlear outer hair cell apoptotic process|down regulation of outer hair cell apoptosis|down regulation of outer hair cell apoptotic process|down-regulation of cochlear outer hair cell apoptosis|down-regulation of cochlear outer hair cell apoptotic process|down-regulation of outer hair cell apoptosis|down-regulation of outer hair cell apoptotic process|downregulation of cochlear outer hair cell apoptosis|downregulation of cochlear outer hair cell apoptotic process|downregulation of outer hair cell apoptosis|downregulation of outer hair cell apoptotic process|inhibition of cochlear outer hair cell apoptosis|inhibition of cochlear outer hair cell apoptotic process|inhibition of outer hair cell apoptosis|inhibition of outer hair cell apoptotic process|negative regulation of cochlear outer hair cell apoptosis|negative regulation of cochlear outer hair cell apoptotic process|negative regulation of outer hair cell apoptosis http://purl.obolibrary.org/obo/GO_1905586 GO:2000958 biolink:BiologicalProcess negative regulation of cyclodextrin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process. go.json negative regulation of cyclodextrin catabolism http://purl.obolibrary.org/obo/GO_2000958 GO:1905576 biolink:MolecularActivity ganglioside GT1b binding Binding to ganglioside GT1b. go.json http://purl.obolibrary.org/obo/GO_1905576 GO:1905577 biolink:MolecularActivity ganglioside GP1c binding Binding to ganglioside GP1c. go.json http://purl.obolibrary.org/obo/GO_1905577 GO:1905578 biolink:BiologicalProcess regulation of ERBB3 signaling pathway Any process that modulates the frequency, rate or extent of ERBB3 signaling pathway. go.json regulation of ERBB3 signalling pathway|regulation of HER3 signaling pathway|regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway http://purl.obolibrary.org/obo/GO_1905578 GO:1905579 biolink:BiologicalProcess negative regulation of ERBB3 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of ERBB3 signaling pathway. go.json down regulation of ERBB3 signaling pathway|down regulation of ERBB3 signalling pathway|down regulation of HER3 signaling pathway|down regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway|down-regulation of ERBB3 signaling pathway|down-regulation of ERBB3 signalling pathway|down-regulation of HER3 signaling pathway|down-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway|downregulation of ERBB3 signaling pathway|downregulation of ERBB3 signalling pathway|downregulation of HER3 signaling pathway|downregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway|inhibition of ERBB3 signaling pathway|inhibition of ERBB3 signalling pathway|inhibition of HER3 signaling pathway|inhibition of receptor tyrosine-protein kinase erbB-3 signaling pathway|negative regulation of ERBB3 signalling pathway|negative regulation of HER3 signaling pathway|negative regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway http://purl.obolibrary.org/obo/GO_1905579 GO:2000950 biolink:BiologicalProcess positive regulation of xyloglucan metabolic process Any process that activates or increases the frequency, rate or extent of xyloglucan metabolic process. go.json positive regulation of xyloglucan metabolism http://purl.obolibrary.org/obo/GO_2000950 GO:0051162 biolink:BiologicalProcess L-arabitol metabolic process The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. go.json L-arabitol metabolism http://purl.obolibrary.org/obo/GO_0051162 GO:0051163 biolink:BiologicalProcess D-arabitol metabolic process The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. go.json D-arabitol metabolism http://purl.obolibrary.org/obo/GO_0051163 GO:0051160 biolink:BiologicalProcess L-xylitol catabolic process The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. go.json L-xylitol breakdown|L-xylitol catabolism|L-xylitol degradation http://purl.obolibrary.org/obo/GO_0051160 GO:0075110 biolink:BiologicalProcess obsolete induction by symbiont of host receptor-mediated signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host receptor-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075110 GO:0051161 biolink:BiologicalProcess arabitol metabolic process The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. go.json arabitol metabolism http://purl.obolibrary.org/obo/GO_0051161 GO:0075111 biolink:BiologicalProcess symbiont-mediated suppression of host receptor-mediated signal transduction A process in which a virus interferes with, inhibits or disrupts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host receptor-mediated signal transduction|negative regulation by symbiont of host receptor-mediated signal transduction|suppression by symbiont of host receptor-mediated signal transduction http://purl.obolibrary.org/obo/GO_0075111 GO:0051166 biolink:BiologicalProcess 2,5-dihydroxypyridine catabolic process The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine. go.json 2,5-dihydroxypyridine breakdown|2,5-dihydroxypyridine catabolism|2,5-dihydroxypyridine degradation|pyridine-2,5-diol catabolic process http://purl.obolibrary.org/obo/GO_0051166 GO:0099108 biolink:MolecularActivity potassium channel activator activity involved in G protein-coupled receptor signaling pathway Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling. go.json potassium channel activator activity involved in G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0099108 goslim_synapse GO:0075112 biolink:BiologicalProcess perturbation of host transmembrane receptor-mediated signal transduction Any process in which the symbiont alters a transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host transmembrane receptor-mediated signal transduction http://purl.obolibrary.org/obo/GO_0075112 GO:0099109 biolink:BiologicalProcess potassium channel activating, G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel. go.json potassium channel activating, G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0099109 GO:0051167 biolink:BiologicalProcess xylulose 5-phosphate metabolic process The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway. go.json D-xylulose 5-phosphate metabolic process|D-xylulose 5-phosphate metabolism|D-xylulose-5-phosphate metabolic process|D-xylulose-5-phosphate metabolism|xylulose 5-phosphate metabolism|xylulose-5-phosphate metabolic process|xylulose-5-phosphate metabolism http://purl.obolibrary.org/obo/GO_0051167 GO:0075113 biolink:BiologicalProcess obsolete induction by symbiont of host transmembrane receptor-mediated signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host transmembrane receptor-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075113 GO:0051164 biolink:BiologicalProcess L-xylitol metabolic process The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets. go.json L-xylitol metabolism http://purl.obolibrary.org/obo/GO_0051164 GO:0099106 biolink:MolecularActivity ion channel regulator activity Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. go.json http://purl.obolibrary.org/obo/GO_0099106 GO:0075114 biolink:BiologicalProcess symbiont-mediated suppression of host transmembrane receptor-mediated signal transduction A process in which a symbiont interferes with, inhibits or disrupts a transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host transmembrane receptor-mediated signal transduction|negative regulation by symbiont of host transmembrane receptor-mediated signal transduction|suppression by symbiont of host transmembrane receptor-mediated signal transduction http://purl.obolibrary.org/obo/GO_0075114 GO:0099107 biolink:MolecularActivity ion channel regulator activity involved in G protein-coupled receptor signaling pathway Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling. go.json ion channel regulator activity involved in G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0099107 GO:0051165 biolink:BiologicalProcess 2,5-dihydroxypyridine metabolic process The chemical reactions and pathways involving 2,5-dihydroxypyridine. go.json 2,5-dihydroxypyridine metabolism|pyridine-2,5-diol metabolic process http://purl.obolibrary.org/obo/GO_0051165 GO:0075148 biolink:BiologicalProcess obsolete positive regulation of signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075148 GO:0075149 biolink:BiologicalProcess obsolete negative regulation of signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075149 GO:0051179 biolink:BiologicalProcess localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. go.json establishment and maintenance of cellular component location|establishment and maintenance of localization|establishment and maintenance of position|establishment and maintenance of substance location|establishment and maintenance of substrate location|localisation|single organism localization|single-organism localization http://purl.obolibrary.org/obo/GO_0051179 goslim_pir GO:0110078 biolink:CellularComponent TTT Hsp90 cochaperone complex A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family. go.json TELO2-TTI1-TTI2|TTT complex|Tel2-Tti1-Tti2|Triple T complex http://purl.obolibrary.org/obo/GO_0110078 GO:0110079 biolink:BiologicalProcess regulation of placenta blood vessel development Any process that modulates the frequency, rate or extent of placenta blood vessel development. go.json http://purl.obolibrary.org/obo/GO_0110079 GO:0110076 biolink:BiologicalProcess negative regulation of ferroptosis Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis. go.json http://purl.obolibrary.org/obo/GO_0110076 GO:0110077 biolink:BiologicalProcess vesicle-mediated intercellular transport A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. go.json http://purl.obolibrary.org/obo/GO_0110077 GO:1905590 biolink:BiologicalProcess fibronectin fibril organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril. go.json http://purl.obolibrary.org/obo/GO_1905590 GO:0110074 biolink:BiologicalProcess positive regulation of apical constriction involved in ventral furrow formation Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation. go.json http://purl.obolibrary.org/obo/GO_0110074 GO:2000962 biolink:BiologicalProcess positive regulation of cellooligosaccharide metabolic process Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process. go.json positive regulation of cellooligosaccharide metabolism http://purl.obolibrary.org/obo/GO_2000962 GO:0110075 biolink:BiologicalProcess regulation of ferroptosis Any process that modulates the frequency, rate or extent of ferroptosis. go.json http://purl.obolibrary.org/obo/GO_0110075 GO:2000963 biolink:BiologicalProcess regulation of cellooligosaccharide catabolic process Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process. go.json regulation of cellooligosaccharide catabolism http://purl.obolibrary.org/obo/GO_2000963 GO:1905591 biolink:BiologicalProcess regulation of optical nerve axon regeneration Any process that modulates the frequency, rate or extent of optical nerve axon regeneration. go.json http://purl.obolibrary.org/obo/GO_1905591 GO:1905592 biolink:BiologicalProcess negative regulation of optical nerve axon regeneration Any process that stops, prevents or reduces the frequency, rate or extent of optical nerve axon regeneration. go.json down regulation of optical nerve axon regeneration|down-regulation of optical nerve axon regeneration|downregulation of optical nerve axon regeneration|inhibition of optical nerve axon regeneration http://purl.obolibrary.org/obo/GO_1905592 GO:0110072 biolink:BiologicalProcess apical constriction involved in ventral furrow formation The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0110072 GO:2000964 biolink:BiologicalProcess negative regulation of cellooligosaccharide catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process. go.json negative regulation of cellooligosaccharide catabolism http://purl.obolibrary.org/obo/GO_2000964 GO:1905593 biolink:BiologicalProcess positive regulation of optical nerve axon regeneration Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration. go.json activation of optical nerve axon regeneration|up regulation of optical nerve axon regeneration|up-regulation of optical nerve axon regeneration|upregulation of optical nerve axon regeneration http://purl.obolibrary.org/obo/GO_1905593 GO:2000965 biolink:BiologicalProcess positive regulation of cellooligosaccharide catabolic process Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process. go.json positive regulation of cellooligosaccharide catabolism http://purl.obolibrary.org/obo/GO_2000965 GO:0110073 biolink:BiologicalProcess regulation of apical constriction involved in ventral furrow formation Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation. go.json http://purl.obolibrary.org/obo/GO_0110073 GO:1905594 biolink:MolecularActivity resveratrol binding Binding to resveratrol. go.json http://purl.obolibrary.org/obo/GO_1905594 GO:2000966 biolink:BiologicalProcess regulation of cell wall polysaccharide catabolic process Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process. go.json regulation of cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_2000966 GO:0110070 biolink:CellularComponent cellularization cleavage furrow A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells. go.json http://purl.obolibrary.org/obo/GO_0110070 GO:2000967 biolink:BiologicalProcess negative regulation of cell wall polysaccharide catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process. go.json negative regulation of cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_2000967 GO:1905595 biolink:BiologicalProcess regulation of low-density lipoprotein particle receptor binding Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding. go.json regulation of LDL receptor binding|regulation of low-density lipoprotein receptor binding http://purl.obolibrary.org/obo/GO_1905595 gocheck_do_not_annotate GO:0110071 biolink:CellularComponent cellularization cleavage furrow invagination front The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0110071 GO:1905596 biolink:BiologicalProcess negative regulation of low-density lipoprotein particle receptor binding Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding. go.json down regulation of LDL receptor binding|down regulation of low-density lipoprotein particle receptor binding|down regulation of low-density lipoprotein receptor binding|down-regulation of LDL receptor binding|down-regulation of low-density lipoprotein particle receptor binding|down-regulation of low-density lipoprotein receptor binding|downregulation of LDL receptor binding|downregulation of low-density lipoprotein particle receptor binding|downregulation of low-density lipoprotein receptor binding|inhibition of LDL receptor binding|inhibition of low-density lipoprotein particle receptor binding|inhibition of low-density lipoprotein receptor binding|negative regulation of LDL receptor binding|negative regulation of low-density lipoprotein receptor binding http://purl.obolibrary.org/obo/GO_1905596 gocheck_do_not_annotate GO:2000968 biolink:BiologicalProcess positive regulation of cell wall polysaccharide catabolic process Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process. go.json positive regulation of cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_2000968 GO:1905597 biolink:BiologicalProcess positive regulation of low-density lipoprotein particle receptor binding Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding. go.json activation of LDL receptor binding|activation of low-density lipoprotein particle receptor binding|activation of low-density lipoprotein receptor binding|positive regulation of LDL receptor binding|positive regulation of low-density lipoprotein receptor binding|up regulation of LDL receptor binding|up regulation of low-density lipoprotein particle receptor binding|up regulation of low-density lipoprotein receptor binding|up-regulation of LDL receptor binding|up-regulation of low-density lipoprotein particle receptor binding|up-regulation of low-density lipoprotein receptor binding|upregulation of LDL receptor binding|upregulation of low-density lipoprotein particle receptor binding|upregulation of low-density lipoprotein receptor binding http://purl.obolibrary.org/obo/GO_1905597 gocheck_do_not_annotate GO:2000969 biolink:BiologicalProcess positive regulation of AMPA receptor activity Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity. go.json positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_2000969 gocheck_do_not_annotate GO:1905587 biolink:BiologicalProcess positive regulation of outer hair cell apoptotic process Any process that activates or increases the frequency, rate or extent of outer hair cell apoptotic process. go.json activation of cochlear outer hair cell apoptosis|activation of cochlear outer hair cell apoptotic process|activation of outer hair cell apoptosis|activation of outer hair cell apoptotic process|positive regulation of cochlear outer hair cell apoptosis|positive regulation of cochlear outer hair cell apoptotic process|positive regulation of outer hair cell apoptosis|up regulation of cochlear outer hair cell apoptosis|up regulation of cochlear outer hair cell apoptotic process|up regulation of outer hair cell apoptosis|up regulation of outer hair cell apoptotic process|up-regulation of cochlear outer hair cell apoptosis|up-regulation of cochlear outer hair cell apoptotic process|up-regulation of outer hair cell apoptosis|up-regulation of outer hair cell apoptotic process|upregulation of cochlear outer hair cell apoptosis|upregulation of cochlear outer hair cell apoptotic process|upregulation of outer hair cell apoptosis|upregulation of outer hair cell apoptotic process http://purl.obolibrary.org/obo/GO_1905587 GO:1905588 biolink:BiologicalProcess plant-type cell wall modification involved in stomatal movement Any plant-type cell wall modification that is involved in stomatal movement. go.json cellulose and pectin-containing cell wall modification involved in stomatal movement http://purl.obolibrary.org/obo/GO_1905588 GO:1905589 biolink:BiologicalProcess positive regulation of L-arginine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane. go.json activation of L-arginine import|activation of L-arginine import across plasma membrane|activation of L-arginine import into cell|activation of L-arginine uptake|positive regulation of L-arginine import|positive regulation of L-arginine import into cell|positive regulation of L-arginine uptake|up regulation of L-arginine import|up regulation of L-arginine uptake|up-regulation of L-arginine import|up-regulation of L-arginine import into cell|up-regulation of L-arginine uptake|upregulation of L-arginine import|upregulation of L-arginine import into cell|upregulation of L-arginine uptake http://purl.obolibrary.org/obo/GO_1905589 GO:0051170 biolink:BiologicalProcess import into nucleus The directed movement of substances into the nucleus. go.json nuclear import|nuclear translocation http://purl.obolibrary.org/obo/GO_0051170 GO:2000960 biolink:BiologicalProcess regulation of cellooligosaccharide metabolic process Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process. go.json regulation of cellooligosaccharide metabolism http://purl.obolibrary.org/obo/GO_2000960 GO:2000961 biolink:BiologicalProcess negative regulation of cellooligosaccharide metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process. go.json negative regulation of cellooligosaccharide metabolism http://purl.obolibrary.org/obo/GO_2000961 GO:0051173 biolink:BiologicalProcess positive regulation of nitrogen compound metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. go.json activation of nitrogen metabolic process|positive regulation of nitrogen metabolic process|positive regulation of nitrogen metabolism|stimulation of nitrogen metabolic process|up regulation of nitrogen metabolic process|up-regulation of nitrogen metabolic process|upregulation of nitrogen metabolic process http://purl.obolibrary.org/obo/GO_0051173 GO:0075140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075140 GO:0075141 biolink:BiologicalProcess obsolete symbiont tolerance to host environment OBSOLETE. Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json maintenance of symbiont tolerance to host environment|maintenance of symbiont tolerance to host iron concentration|maintenance of symbiont tolerance to host osmotic environment|maintenance of symbiont tolerance to host oxygen tension environment|maintenance of symbiont tolerance to host pH environment|maintenance of symbiont tolerance to host redox environment True http://purl.obolibrary.org/obo/GO_0075141 GO:0051174 biolink:BiologicalProcess regulation of phosphorus metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. go.json regulation of phosphorus metabolism http://purl.obolibrary.org/obo/GO_0051174 GO:0051171 biolink:BiologicalProcess regulation of nitrogen compound metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. go.json regulation of nitrogen metabolic process|regulation of nitrogen metabolism http://purl.obolibrary.org/obo/GO_0051171 GO:0075142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075142 GO:0051172 biolink:BiologicalProcess negative regulation of nitrogen compound metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. go.json down regulation of nitrogen metabolic process|down-regulation of nitrogen metabolic process|downregulation of nitrogen metabolic process|inhibition of nitrogen metabolic process|negative regulation of nitrogen metabolic process|negative regulation of nitrogen metabolism http://purl.obolibrary.org/obo/GO_0051172 GO:0075143 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075143 GO:0090741 biolink:CellularComponent pigment granule membrane Any membrane that is part of a pigment granule. go.json http://purl.obolibrary.org/obo/GO_0090741 GO:0051177 biolink:BiologicalProcess meiotic sister chromatid cohesion The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. go.json http://purl.obolibrary.org/obo/GO_0051177 GO:0075144 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075144 GO:0051178 biolink:BiologicalProcess obsolete meiotic chromosome decondensation OBSOLETE. The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells. go.json True http://purl.obolibrary.org/obo/GO_0051178 GO:0075145 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075145 GO:0051175 biolink:BiologicalProcess negative regulation of sulfur metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. go.json down regulation of sulfur metabolic process|down-regulation of sulfur metabolic process|downregulation of sulfur metabolic process|inhibition of sulfur metabolic process|negative regulation of sulfur metabolism|negative regulation of sulphur metabolic process|negative regulation of sulphur metabolism http://purl.obolibrary.org/obo/GO_0051175 GO:0075146 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075146 GO:0090740 biolink:CellularComponent obsolete integral component of pigment granule membrane OBSOLETE. The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0090740 GO:0051176 biolink:BiologicalProcess positive regulation of sulfur metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. go.json activation of sulfur metabolic process|positive regulation of sulfur metabolism|positive regulation of sulphur metabolic process|positive regulation of sulphur metabolism|stimulation of sulfur metabolic process|up regulation of sulfur metabolic process|up-regulation of sulfur metabolic process|upregulation of sulfur metabolic process http://purl.obolibrary.org/obo/GO_0051176 GO:0075147 biolink:BiologicalProcess obsolete regulation of signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075147 GO:0075137 biolink:BiologicalProcess response to host redox environment Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response of symbiont to host redox environment http://purl.obolibrary.org/obo/GO_0075137 GO:0075138 biolink:BiologicalProcess response to host oxygen tension environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response of symbiont to host oxygen tension environment http://purl.obolibrary.org/obo/GO_0075138 GO:0075139 biolink:BiologicalProcess response to host iron concentration Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response of symbiont to host iron concentration http://purl.obolibrary.org/obo/GO_0075139 GO:0110089 biolink:BiologicalProcess regulation of hippocampal neuron apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons. go.json http://purl.obolibrary.org/obo/GO_0110089 GO:0110087 biolink:BiologicalProcess obsolete suppression by virus of host protease activator activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protease activator activity. go.json True http://purl.obolibrary.org/obo/GO_0110087 GO:0110088 biolink:BiologicalProcess hippocampal neuron apoptotic process Any apoptotic process that occurs in a hippocampal neuron. go.json http://purl.obolibrary.org/obo/GO_0110088 GO:2000973 biolink:BiologicalProcess regulation of pro-B cell differentiation Any process that modulates the frequency, rate or extent of pro-B cell differentiation. go.json regulation of pro-B cell development|regulation of pro-B lymphocyte differentiation http://purl.obolibrary.org/obo/GO_2000973 GO:0110085 biolink:CellularComponent mitotic actomyosin contractile ring A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. go.json http://purl.obolibrary.org/obo/GO_0110085 GO:0110086 biolink:CellularComponent meiotic actomyosin contractile ring A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0110086 GO:2000974 biolink:BiologicalProcess negative regulation of pro-B cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation. go.json negative regulation of pro-B cell development|negative regulation of pro-B lymphocyte differentiation http://purl.obolibrary.org/obo/GO_2000974 GO:0110083 biolink:BiologicalProcess positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. go.json http://purl.obolibrary.org/obo/GO_0110083 GO:2000975 biolink:BiologicalProcess positive regulation of pro-B cell differentiation Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation. go.json positive regulation of pro-B cell development|positive regulation of pro-B lymphocyte differentiation http://purl.obolibrary.org/obo/GO_2000975 GO:2000976 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in detection of glucose OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in detection of glucose. go.json global transcription regulation from Pol II promoter involved in detection of glucose|global transcription regulation from Pol II promoter involved in glucose detection|global transcription regulation from Pol II promoter involved in glucose perception|global transcription regulation from Pol II promoter involved in glucose sensing|regulation of gene-specific transcription from RNA polymerase II promoter involved in detection of glucose|regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose detection|regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose perception|regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose sensing|regulation of global transcription from Pol II promoter involved in detection of glucose|regulation of global transcription from Pol II promoter involved in glucose detection|regulation of global transcription from Pol II promoter involved in glucose perception|regulation of global transcription from Pol II promoter involved in glucose sensing|regulation of transcription from Pol II promoter involved in detection of glucose|regulation of transcription from Pol II promoter involved in glucose detection|regulation of transcription from Pol II promoter involved in glucose perception|regulation of transcription from Pol II promoter involved in glucose sensing|regulation of transcription from RNA polymerase II promoter involved in glucose detection|regulation of transcription from RNA polymerase II promoter involved in glucose perception|regulation of transcription from RNA polymerase II promoter involved in glucose sensing|regulation of transcription from RNA polymerase II promoter, global involved in detection of glucose|regulation of transcription from RNA polymerase II promoter, global involved in glucose detection|regulation of transcription from RNA polymerase II promoter, global involved in glucose perception|regulation of transcription from RNA polymerase II promoter, global involved in glucose sensing True http://purl.obolibrary.org/obo/GO_2000976 GO:0110084 biolink:BiologicalProcess negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. go.json http://purl.obolibrary.org/obo/GO_0110084 GO:0110081 biolink:BiologicalProcess negative regulation of placenta blood vessel development Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development. go.json http://purl.obolibrary.org/obo/GO_0110081 GO:2000977 biolink:BiologicalProcess regulation of forebrain neuron differentiation Any process that modulates the frequency, rate or extent of forebrain neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_2000977 GO:2000978 biolink:BiologicalProcess negative regulation of forebrain neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_2000978 GO:0110082 biolink:BiologicalProcess regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. go.json http://purl.obolibrary.org/obo/GO_0110082 GO:2000979 biolink:BiologicalProcess positive regulation of forebrain neuron differentiation Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_2000979 GO:0110080 biolink:BiologicalProcess positive regulation of placenta blood vessel development Any process that activates or increases the frequency, rate or extent of placenta blood vessel development. go.json http://purl.obolibrary.org/obo/GO_0110080 GO:1905598 biolink:BiologicalProcess negative regulation of low-density lipoprotein receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity. go.json down regulation of LDL receptor|down regulation of LDLR activity|down regulation of low-density lipoprotein receptor activity|down-regulation of LDL receptor|down-regulation of LDLR activity|down-regulation of low-density lipoprotein receptor activity|downregulation of LDL receptor|downregulation of LDLR activity|downregulation of low-density lipoprotein receptor activity|inhibition of LDL receptor|inhibition of LDLR activity|inhibition of low-density lipoprotein receptor activity|negative regulation of LDL receptor|negative regulation of LDLR activity http://purl.obolibrary.org/obo/GO_1905598 gocheck_do_not_annotate GO:1905599 biolink:BiologicalProcess positive regulation of low-density lipoprotein receptor activity Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity. go.json activation of LDL receptor|activation of LDLR activity|activation of low-density lipoprotein receptor activity|positive regulation of LDL receptor|positive regulation of LDLR activity|up regulation of LDL receptor|up regulation of LDLR activity|up regulation of low-density lipoprotein receptor activity|up-regulation of LDL receptor|up-regulation of LDLR activity|up-regulation of low-density lipoprotein receptor activity|upregulation of LDL receptor|upregulation of LDLR activity|upregulation of low-density lipoprotein receptor activity http://purl.obolibrary.org/obo/GO_1905599 gocheck_do_not_annotate GO:0051180 biolink:BiologicalProcess vitamin transport The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json vitamin or cofactor transport http://purl.obolibrary.org/obo/GO_0051180 goslim_pir GO:0051181 biolink:BiologicalProcess obsolete cofactor transport OBSOLETE. The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. go.json vitamin or cofactor transport True http://purl.obolibrary.org/obo/GO_0051181 GO:2000970 biolink:BiologicalProcess regulation of detection of glucose Any process that modulates the frequency, rate or extent of detection of glucose. go.json regulation of glucose detection|regulation of glucose perception|regulation of glucose sensing http://purl.obolibrary.org/obo/GO_2000970 GO:2000971 biolink:BiologicalProcess negative regulation of detection of glucose Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose. go.json negative regulation of glucose detection|negative regulation of glucose perception|negative regulation of glucose sensing http://purl.obolibrary.org/obo/GO_2000971 GO:2000972 biolink:BiologicalProcess positive regulation of detection of glucose Any process that activates or increases the frequency, rate or extent of detection of glucose. go.json positive regulation of glucose detection|positive regulation of glucose perception|positive regulation of glucose sensing http://purl.obolibrary.org/obo/GO_2000972 GO:0051184 biolink:MolecularActivity obsolete cofactor transmembrane transporter activity OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein. go.json cofactor transporter activity|vitamin or cofactor transporter activity True http://purl.obolibrary.org/obo/GO_0051184 GO:0051185 biolink:MolecularActivity obsolete coenzyme transmembrane transporter activity OBSOLETE. Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. go.json coenzyme transporter activity True http://purl.obolibrary.org/obo/GO_0051185 GO:0075130 biolink:BiologicalProcess obsolete perturbation of host protein kinase-mediated signal transduction OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host protein kinase-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075130 GO:0051182 biolink:BiologicalProcess obsolete coenzyme transport OBSOLETE. The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. go.json True http://purl.obolibrary.org/obo/GO_0051182 GO:0075131 biolink:BiologicalProcess obsolete induction by symbiont of host protein kinase-mediated signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075131 GO:0075132 biolink:BiologicalProcess obsolete disruption of host protein kinase-mediated signal transduction OBSOLETE. Any process in which a symbiont interferes with protein kinase-mediated signal transduction in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by symbiont of host protein kinase-mediated signal transduction|suppression by symbiont of host protein kinase-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075132 GO:0051183 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051183 GO:0051188 biolink:BiologicalProcess obsolete cofactor biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. go.json cofactor anabolism|cofactor biosynthesis|cofactor formation|cofactor synthesis True http://purl.obolibrary.org/obo/GO_0051188 GO:0075133 biolink:BiologicalProcess perturbation of host calcium or calmodulin-mediated signal transduction A process in which a symbiont alters or subverts a calcium or calmodulin-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction http://purl.obolibrary.org/obo/GO_0075133 GO:0051189 biolink:BiologicalProcess prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. go.json coenzyme and prosthetic group metabolic process|coenzyme and prosthetic group metabolism|prosthetic group metabolism http://purl.obolibrary.org/obo/GO_0051189 goslim_pir GO:0075134 biolink:BiologicalProcess obsolete induction by symbiont of host calcium or calmodulin-mediated signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction|positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0075134 GO:0075135 biolink:BiologicalProcess symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction A process in which a virus interferes with, inhibits or disrupts a calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host calcium or calmodulin-mediated signal transduction|negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction|negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction|suppression by symbiont of host calcium or calmodulin-mediated signal transduction http://purl.obolibrary.org/obo/GO_0075135 GO:0051186 biolink:BiologicalProcess obsolete cofactor metabolic process OBSOLETE. The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. go.json cofactor metabolism True http://purl.obolibrary.org/obo/GO_0051186 GO:0051187 biolink:BiologicalProcess obsolete cofactor catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. go.json cofactor breakdown|cofactor catabolism|cofactor degradation True http://purl.obolibrary.org/obo/GO_0051187 GO:0075136 biolink:BiologicalProcess response to host Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response of symbiont to host http://purl.obolibrary.org/obo/GO_0075136 GO:0002104 biolink:BiologicalProcess endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0002104 GO:0002105 biolink:BiologicalProcess endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0002105 GO:0002106 biolink:BiologicalProcess endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0002106 GO:0002107 biolink:BiologicalProcess generation of mature 3'-end of 5S rRNA generated by RNA polymerase III The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end. go.json http://purl.obolibrary.org/obo/GO_0002107 GO:0002100 biolink:BiologicalProcess tRNA wobble adenosine to inosine editing The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine. go.json http://purl.obolibrary.org/obo/GO_0002100 GO:0002101 biolink:BiologicalProcess tRNA wobble cytosine modification The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified. go.json http://purl.obolibrary.org/obo/GO_0002101 GO:0002102 biolink:CellularComponent podosome An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. Wikipedia:Podosome go.json http://purl.obolibrary.org/obo/GO_0002102 GO:0002103 biolink:BiologicalProcess endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0002103 GO:0016749 biolink:MolecularActivity N-succinyltransferase activity Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016749 GO:0016745 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016745 GO:0016746 biolink:MolecularActivity acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). EC:2.3.-.-|Reactome:R-HSA-159431|Reactome:R-HSA-192312|Reactome:R-HSA-193491|Reactome:R-HSA-6792572|Reactome:R-HSA-8858298 go.json transferase activity, transferring acyl groups http://purl.obolibrary.org/obo/GO_0016746 goslim_chembl|goslim_drosophila GO:0016747 biolink:MolecularActivity acyltransferase activity, transferring groups other than amino-acyl groups Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). EC:2.3.1.- go.json transferase activity, transferring acyl groups other than amino-acyl groups|transferase activity, transferring groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0016747 GO:0016748 biolink:MolecularActivity succinyltransferase activity Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016748 GO:0016741 biolink:MolecularActivity transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). EC:2.1.-.- go.json methyltransferase activity http://purl.obolibrary.org/obo/GO_0016741 GO:0016742 biolink:MolecularActivity hydroxymethyl-, formyl- and related transferase activity Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). EC:2.1.2.- go.json http://purl.obolibrary.org/obo/GO_0016742 GO:0016743 biolink:MolecularActivity carboxyl- or carbamoyltransferase activity Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). EC:2.1.3.- go.json carboxyl- and carbamoyltransferase activity http://purl.obolibrary.org/obo/GO_0016743 GO:0016744 biolink:MolecularActivity transketolase or transaldolase activity Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). EC:2.2.1.- go.json transferase activity, transferring aldehyde or ketonic groups http://purl.obolibrary.org/obo/GO_0016744 GO:0016740 biolink:MolecularActivity transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. EC:2.-.-.-|Reactome:R-HSA-1483089|Reactome:R-HSA-1483186|Reactome:R-HSA-5668414|Reactome:R-HSA-8868783 go.json http://purl.obolibrary.org/obo/GO_0016740 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0002108 biolink:BiologicalProcess maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0002108 GO:0002109 biolink:BiologicalProcess maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0002109 GO:0002115 biolink:BiologicalProcess store-operated calcium entry A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. go.json SOCE|calcium ion import|capacitative calcium entry|store-operated calcium import http://purl.obolibrary.org/obo/GO_0002115 GO:0002116 biolink:CellularComponent semaphorin receptor complex A stable binary complex of a semaphorin and a plexin, together forming a functional semaphorin receptor. go.json plexin-neurophilin complex http://purl.obolibrary.org/obo/GO_0002116 GO:0002117 biolink:BiologicalProcess amphibian larval development The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form. go.json http://purl.obolibrary.org/obo/GO_0002117 GO:0002118 biolink:BiologicalProcess aggressive behavior A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual. Wikipedia:Aggression go.json aggression http://purl.obolibrary.org/obo/GO_0002118 GO:0002111 biolink:CellularComponent BRCA2-BRAF35 complex A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis. go.json http://purl.obolibrary.org/obo/GO_0002111 GO:0002112 biolink:MolecularActivity interleukin-33 receptor binding Binding to an interleukin-33 receptor. go.json IL-33|interleukin-33 receptor ligand http://purl.obolibrary.org/obo/GO_0002112 GO:0002113 biolink:MolecularActivity interleukin-33 binding Binding to interleukin-33. go.json IL-33 binding http://purl.obolibrary.org/obo/GO_0002113 GO:0002114 biolink:MolecularActivity interleukin-33 receptor activity Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-33 receptor activity|IL-33R http://purl.obolibrary.org/obo/GO_0002114 GO:0002110 biolink:BiologicalProcess cotranscriptional mitochondrial rRNA nucleotide insertion The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis. go.json http://purl.obolibrary.org/obo/GO_0002110 GO:0016756 biolink:MolecularActivity glutathione gamma-glutamylcysteinyltransferase activity Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. EC:2.3.2.15|MetaCyc:2.3.2.15-RXN|RHEA:17917 go.json phytochelatin synthase activity http://purl.obolibrary.org/obo/GO_0016756 GO:0016757 biolink:MolecularActivity glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). EC:2.4.-.-|Reactome:R-HSA-5173005|Reactome:R-HSA-6785565 go.json transferase activity, transferring glycosyl groups|transferase activity, transferring other glycosyl groups|transglycosidase activity|transglycosylase activity http://purl.obolibrary.org/obo/GO_0016757 goslim_chembl|goslim_drosophila|goslim_yeast GO:0016758 biolink:MolecularActivity hexosyltransferase activity Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). EC:2.4.1.- go.json transferase activity, transferring hexosyl groups http://purl.obolibrary.org/obo/GO_0016758 GO:0016759 biolink:MolecularActivity cellulose synthase activity Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). go.json cellulose synthetase activity http://purl.obolibrary.org/obo/GO_0016759 GO:0016752 biolink:MolecularActivity sinapoyltransferase activity Catalysis of the transfer of a sinapoyl group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016752 GO:0016753 biolink:MolecularActivity O-sinapoyltransferase activity Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016753 GO:0016754 biolink:MolecularActivity sinapoylglucose-malate O-sinapoyltransferase activity Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate. EC:2.3.1.92|KEGG_REACTION:R03323|MetaCyc:2.3.1.92-RXN|RHEA:12625 go.json 1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity|1-sinapoylglucose-L-malate sinapoyltransferase activity|sinapoylglucose:malate sinapoyltransferase activity http://purl.obolibrary.org/obo/GO_0016754 GO:0016755 biolink:MolecularActivity aminoacyltransferase activity Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). EC:2.3.2.- go.json transferase activity, transferring amino-acyl groups http://purl.obolibrary.org/obo/GO_0016755 GO:0016750 biolink:MolecularActivity O-succinyltransferase activity Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016750 GO:0016751 biolink:MolecularActivity S-succinyltransferase activity Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0016751 GO:0002119 biolink:BiologicalProcess nematode larval development The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. go.json http://purl.obolibrary.org/obo/GO_0002119 GO:0016727 biolink:MolecularActivity oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. EC:1.17.3.- go.json http://purl.obolibrary.org/obo/GO_0016727 GO:0016728 biolink:MolecularActivity oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. EC:1.17.4.- go.json oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor http://purl.obolibrary.org/obo/GO_0016728 GO:0016729 biolink:MolecularActivity obsolete oxidoreductase activity, acting on CH2 groups, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen. go.json oxidoreductase activity, acting on CH2 groups, other acceptors True http://purl.obolibrary.org/obo/GO_0016729 GO:0016723 biolink:MolecularActivity oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor. EC:1.16.1.-|Reactome:R-HSA-917811 go.json oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016723 GO:0016724 biolink:MolecularActivity oxidoreductase activity, acting on metal ions, oxygen as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. EC:1.16.3.- go.json oxidoreductase activity, oxidizing metal ions, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0016724 GO:0016725 biolink:MolecularActivity oxidoreductase activity, acting on CH or CH2 groups Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.17.-.- go.json oxidoreductase activity, acting on CH or CH2 groups, other acceptors http://purl.obolibrary.org/obo/GO_0016725 GO:0016726 biolink:MolecularActivity oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. EC:1.17.1.- go.json http://purl.obolibrary.org/obo/GO_0016726 GO:0016720 biolink:MolecularActivity delta12-fatty acid dehydrogenase activity Catalysis of the reaction: AH(2) + linoleate + O2 = A + crepenynate + 2 H2O. EC:1.14.99.33|KEGG_REACTION:R05740|MetaCyc:1.14.99.33-RXN|RHEA:23456 go.json D12-fatty acid dehydrogenase activity|crepenynate synthase activity|delta-12 fatty acid acetylenase activity|delta12 fatty acid acetylenase activity|linoleate delta-12-fatty acid acetylenase (desaturase) activity|linoleate delta12-fatty acid acetylenase (desaturase)|linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating) http://purl.obolibrary.org/obo/GO_0016720 GO:0016721 biolink:MolecularActivity oxidoreductase activity, acting on superoxide radicals as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor. EC:1.15.-.- go.json http://purl.obolibrary.org/obo/GO_0016721 GO:0016722 biolink:MolecularActivity oxidoreductase activity, acting on metal ions Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. EC:1.16.-.-|Reactome:R-HSA-917805 go.json oxidoreductase activity, oxidizing metal ions|oxidoreductase activity, reducing metal ions http://purl.obolibrary.org/obo/GO_0016722 GO:0016738 biolink:MolecularActivity oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen. EC:1.19.6.- go.json http://purl.obolibrary.org/obo/GO_0016738 GO:0016739 biolink:MolecularActivity obsolete oxidoreductase activity, acting on other substrates OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized. go.json oxidoreductase activity, acting on other substrates True http://purl.obolibrary.org/obo/GO_0016739 GO:0016734 biolink:MolecularActivity obsolete molybdenum-iron nitrogenase activity OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. go.json molybdenum-iron nitrogenase activity True http://purl.obolibrary.org/obo/GO_0016734 GO:0016735 biolink:MolecularActivity obsolete vanadium-iron nitrogenase activity OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. go.json vanadium-iron nitrogenase activity True http://purl.obolibrary.org/obo/GO_0016735 GO:0016736 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016736 GO:0016737 biolink:MolecularActivity oxidoreductase activity, acting on reduced flavodoxin as donor Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.19.-.- go.json http://purl.obolibrary.org/obo/GO_0016737 GO:0016730 biolink:MolecularActivity oxidoreductase activity, acting on iron-sulfur proteins as donors Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.18.-.- go.json oxidoreductase activity, acting on iron-sulphur proteins as donors http://purl.obolibrary.org/obo/GO_0016730 GO:0016731 biolink:MolecularActivity oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.18.1.- go.json http://purl.obolibrary.org/obo/GO_0016731 GO:0016732 biolink:MolecularActivity oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen. EC:1.18.6.- go.json http://purl.obolibrary.org/obo/GO_0016732 GO:0016733 biolink:MolecularActivity obsolete iron-iron nitrogenase activity OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. go.json iron-iron nitrogenase activity True http://purl.obolibrary.org/obo/GO_0016733 GO:0016709 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. EC:1.14.13.-|Reactome:R-HSA-2162187|Reactome:R-HSA-2162194 go.json oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016709 GO:0016705 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. EC:1.14.-.- go.json oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous http://purl.obolibrary.org/obo/GO_0016705 GO:0016706 biolink:MolecularActivity 2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. EC:1.14.11.-|Reactome:R-HSA-1234164|Reactome:R-HSA-6783455 go.json 2-oxoglutarate dioxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors http://purl.obolibrary.org/obo/GO_0016706 GO:0016707 biolink:MolecularActivity gibberellin 3-beta-dioxygenase activity Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2. EC:1.14.11.15|MetaCyc:RXN1F-170|RHEA:10104 go.json (gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)|(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)|gibberellin 3-beta-hydroxylase activity|gibberellin 3beta-dioxygenase activity|gibberellin 3beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0016707 GO:0016708 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor. EC:1.14.12.- go.json oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor http://purl.obolibrary.org/obo/GO_0016708 GO:0016701 biolink:MolecularActivity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. EC:1.13.-.- go.json oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous|oxygenase http://purl.obolibrary.org/obo/GO_0016701 GO:0016702 biolink:MolecularActivity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. EC:1.13.11.-|Reactome:R-HSA-2161775|Reactome:R-HSA-2161907|Reactome:R-HSA-2161917|Reactome:R-HSA-5164399|Reactome:R-HSA-9018880|Reactome:R-HSA-9020274|Reactome:R-HSA-9026408|Reactome:R-HSA-9026918 go.json http://purl.obolibrary.org/obo/GO_0016702 GO:0016703 biolink:MolecularActivity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor. EC:1.13.12.- go.json http://purl.obolibrary.org/obo/GO_0016703 GO:0016704 biolink:MolecularActivity obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized. go.json oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous True http://purl.obolibrary.org/obo/GO_0016704 GO:0016700 biolink:MolecularActivity obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound. go.json oxidoreductase activity, acting on hydrogen as donor, other acceptors True http://purl.obolibrary.org/obo/GO_0016700 GO:0016716 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. EC:1.14.18.- go.json http://purl.obolibrary.org/obo/GO_0016716 GO:0016717 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. EC:1.14.19.- go.json http://purl.obolibrary.org/obo/GO_0016717 GO:0016718 biolink:MolecularActivity obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized. go.json oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous True http://purl.obolibrary.org/obo/GO_0016718 GO:0016719 biolink:MolecularActivity 9,9'-di-cis-zeta-carotene desaturase activity Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol. EC:1.3.5.6|MetaCyc:RXN-12242|RHEA:30955 go.json carotene 7,8-desaturase activity|carotene,hydrogen-donor:oxygen oxidoreductase activity|zeta-carotene desaturase activity http://purl.obolibrary.org/obo/GO_0016719 GO:0089700 biolink:BiologicalProcess protein kinase D signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound. go.json PKD signal transduction|PKD signaling cascade|protein kinase D signal transduction|protein kinase D signaling cascade|protein kinase D signalling cascade http://purl.obolibrary.org/obo/GO_0089700 GO:0016712 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. EC:1.14.14.-|Reactome:R-HSA-211966|UM-BBD_enzymeID:e0551 go.json aryl hydrocarbon hydroxylase activity|aryl-4-monooxygenase activity|cytochrome P450 CYP19|cytochrome p450 activity|flavoprotein monooxygenase activity|flavoprotein-linked monooxygenase activity|microsomal P-450|microsomal monooxygenase activity|microsomal p450 activity|substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)|unspecific monooxygenase activity|xenobiotic monooxygenase activity http://purl.obolibrary.org/obo/GO_0016712 GO:0089701 biolink:CellularComponent U2AF complex A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point. go.json U2 accessory factor|U2AF http://purl.obolibrary.org/obo/GO_0089701 GO:0016713 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. EC:1.14.15.- go.json oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016713 GO:0089702 biolink:MolecularActivity undecaprenyl-phosphate glucose phosphotransferase activity Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol. go.json http://purl.obolibrary.org/obo/GO_0089702 GO:0089703 biolink:BiologicalProcess L-aspartate transmembrane export from vacuole The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0089703 GO:0016714 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. EC:1.14.16.- go.json http://purl.obolibrary.org/obo/GO_0016714 GO:0089704 biolink:BiologicalProcess L-glutamate transmembrane export from vacuole The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0089704 GO:0016715 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. EC:1.14.17.- go.json http://purl.obolibrary.org/obo/GO_0016715 GO:0089705 biolink:BiologicalProcess protein localization to outer membrane A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane. go.json http://purl.obolibrary.org/obo/GO_0089705 GO:0089706 biolink:BiologicalProcess L-ornithine transmembrane export from vacuole The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0089706 GO:0016710 biolink:MolecularActivity trans-cinnamate 4-monooxygenase activity Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O. EC:1.14.14.91|MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN|RHEA:10608 go.json CA4H activity|cinnamate 4-hydroxylase activity|cinnamate 4-monooxygenase activity|cinnamate hydroxylase activity|cinnamic 4-hydroxylase activity|cinnamic acid 4-hydroxylase activity|cinnamic acid 4-monooxygenase activity|cinnamic acid p-hydroxylase activity|cytochrome P450 cinnamate 4-hydroxylase activity|hydroxylase, cinnamate 4-|oxygenase, cinnamate 4-mono-|t-cinnamic acid hydroxylase activity|trans-cinnamate 4-hydroxylase activity|trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)|trans-cinnamic acid 4-hydroxylase activity http://purl.obolibrary.org/obo/GO_0016710 GO:0089707 biolink:BiologicalProcess L-lysine transmembrane export from vacuole The directed movement of L-lysine out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0089707 GO:0016711 biolink:MolecularActivity flavonoid 3'-monooxygenase activity Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. EC:1.14.14.82|MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN|RHEA:16337 go.json NADPH:flavonoid-3'-hydroxylase activity|flavonoid 3'-hydroxylase activity|flavonoid 3-hydroxylase|flavonoid 3-monooxygenase|flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating) http://purl.obolibrary.org/obo/GO_0016711 GO:0089708 biolink:BiologicalProcess L-histidine transmembrane export from vacuole The directed movement of L-histidine out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0089708 GO:0089709 biolink:BiologicalProcess L-histidine transmembrane transport The directed movement of L-histidine across a membrane. go.json http://purl.obolibrary.org/obo/GO_0089709 GO:1905500 biolink:BiologicalProcess obsolete heteroreceptor complex assembly OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a heteroreceptor complex. go.json heteroreceptor complex formation True http://purl.obolibrary.org/obo/GO_1905500 GO:1905501 biolink:BiologicalProcess obsolete heteroreceptor complex disassembly OBSOLETE. The disaggregation of a heteroreceptor complex into its constituent components. go.json True http://purl.obolibrary.org/obo/GO_1905501 GO:1905502 biolink:MolecularActivity acetyl-CoA binding Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component. go.json acetyl-coenzyme A binding http://purl.obolibrary.org/obo/GO_1905502 GO:1905503 biolink:BiologicalProcess regulation of motile cilium assembly Any process that modulates the frequency, rate or extent of motile cilium assembly. go.json regulation of motile primary cilia assembly|regulation of motile primary cilia formation|regulation of motile primary cilium assembly|regulation of motile primary cilium formation|regulation of nodal cilium assembly|regulation of nodal cilium formation http://purl.obolibrary.org/obo/GO_1905503 GO:1905504 biolink:BiologicalProcess negative regulation of motile cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. go.json down regulation of motile primary cilia assembly|down regulation of motile primary cilia formation|down regulation of motile primary cilium assembly|down regulation of motile primary cilium formation|down regulation of nodal cilium assembly|down regulation of nodal cilium formation|down-regulation of motile primary cilia assembly|down-regulation of motile primary cilia formation|down-regulation of motile primary cilium assembly|down-regulation of motile primary cilium formation|down-regulation of nodal cilium assembly|down-regulation of nodal cilium formation|downregulation of motile primary cilia assembly|downregulation of motile primary cilia formation|downregulation of motile primary cilium assembly|downregulation of motile primary cilium formation|downregulation of nodal cilium assembly|downregulation of nodal cilium formation|inhibition of motile primary cilia assembly|inhibition of motile primary cilia formation|inhibition of motile primary cilium assembly|inhibition of motile primary cilium formation|inhibition of nodal cilium assembly|inhibition of nodal cilium formation|negative regulation of motile primary cilia assembly|negative regulation of motile primary cilia formation|negative regulation of motile primary cilium assembly|negative regulation of motile primary cilium formation|negative regulation of nodal cilium assembly|negative regulation of nodal cilium formation http://purl.obolibrary.org/obo/GO_1905504 GO:1905505 biolink:BiologicalProcess positive regulation of motile cilium assembly Any process that activates or increases the frequency, rate or extent of motile cilium assembly. go.json activation of motile primary cilia assembly|activation of motile primary cilia formation|activation of motile primary cilium assembly|activation of motile primary cilium formation|activation of nodal cilium assembly|activation of nodal cilium formation|positive regulation of motile primary cilia assembly|positive regulation of motile primary cilia formation|positive regulation of motile primary cilium assembly|positive regulation of motile primary cilium formation|positive regulation of nodal cilium assembly|positive regulation of nodal cilium formation|up regulation of motile primary cilia assembly|up regulation of motile primary cilia formation|up regulation of motile primary cilium assembly|up regulation of motile primary cilium formation|up regulation of nodal cilium assembly|up regulation of nodal cilium formation|up-regulation of motile primary cilia assembly|up-regulation of motile primary cilia formation|up-regulation of motile primary cilium assembly|up-regulation of motile primary cilium formation|up-regulation of nodal cilium assembly|up-regulation of nodal cilium formation|upregulation of motile primary cilia assembly|upregulation of motile primary cilia formation|upregulation of motile primary cilium assembly|upregulation of motile primary cilium formation|upregulation of nodal cilium assembly|upregulation of nodal cilium formation http://purl.obolibrary.org/obo/GO_1905505 GO:1905506 biolink:CellularComponent gerontoplast stroma Any plastid stroma that is part of a gerontoplast. go.json http://purl.obolibrary.org/obo/GO_1905506 GO:1905507 biolink:BiologicalProcess obsolete cytoplasmic sequestering of protein involved in mitotic G2 DNA damage checkpoint OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic G2 DNA damage checkpoint. go.json True http://purl.obolibrary.org/obo/GO_1905507 GO:1905508 biolink:BiologicalProcess protein localization to microtubule organizing center A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center. go.json protein localisation in microtubule organizing center|protein localisation to microtubule organizing center|protein localization in microtubule organizing center http://purl.obolibrary.org/obo/GO_1905508 GO:1905509 biolink:BiologicalProcess protein localization to interphase microtubule organizing center A process in which a protein is transported to, or maintained in, a location within an interphase microtubule organizing center. go.json protein localisation in interphase microtubule organizing center|protein localisation to interphase microtubule organizing center|protein localization in interphase microtubule organizing center http://purl.obolibrary.org/obo/GO_1905509 GO:0051104 biolink:BiologicalProcess DNA-dependent DNA replication DNA ligation The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication. go.json DNA ligation during DNA-dependent DNA replication|DNA ligation involved in DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0051104 GO:0051105 biolink:BiologicalProcess regulation of DNA ligation Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. go.json http://purl.obolibrary.org/obo/GO_0051105 GO:0051102 biolink:BiologicalProcess DNA ligation involved in DNA recombination The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination. go.json DNA ligation during DNA recombination http://purl.obolibrary.org/obo/GO_0051102 GO:0051103 biolink:BiologicalProcess DNA ligation involved in DNA repair The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. go.json DNA ligation during DNA repair http://purl.obolibrary.org/obo/GO_0051103 GO:0051108 biolink:MolecularActivity carnitine-CoA ligase activity Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA. MetaCyc:DCARNCOALIG-RXN|RHEA:30543 go.json carnitine synthetase activity|crotonobetaine/carnitine-CoA ligase activity http://purl.obolibrary.org/obo/GO_0051108 GO:0051109 biolink:MolecularActivity crotonobetaine-CoA ligase activity Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA. MetaCyc:CROTCOALIG-RXN|RHEA:30079 go.json crotonobetaine-CoA synthase activity|crotonobetaine/carnitine-CoA ligase activity http://purl.obolibrary.org/obo/GO_0051109 GO:0051106 biolink:BiologicalProcess positive regulation of DNA ligation Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. go.json activation of DNA ligation|stimulation of DNA ligation|up regulation of DNA ligation|up-regulation of DNA ligation|upregulation of DNA ligation http://purl.obolibrary.org/obo/GO_0051106 GO:0051107 biolink:BiologicalProcess negative regulation of DNA ligation Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. go.json down regulation of DNA ligation|down-regulation of DNA ligation|downregulation of DNA ligation|inhibition of DNA ligation http://purl.obolibrary.org/obo/GO_0051107 GO:1905520 biolink:BiologicalProcess positive regulation of presynaptic active zone assembly Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly. go.json activation of pre-synaptic active zone assembly|activation of pre-synaptic active zone component assembly|activation of pre-synaptic active zone component formation|activation of pre-synaptic active zone formation|activation of presynaptic active zone assembly|activation of presynaptic active zone formation|positive regulation of pre-synaptic active zone assembly|positive regulation of pre-synaptic active zone component assembly|positive regulation of pre-synaptic active zone component formation|positive regulation of pre-synaptic active zone formation|positive regulation of presynaptic active zone formation|up regulation of pre-synaptic active zone assembly|up regulation of pre-synaptic active zone component assembly|up regulation of pre-synaptic active zone component formation|up regulation of pre-synaptic active zone formation|up regulation of presynaptic active zone assembly|up regulation of presynaptic active zone formation|up-regulation of pre-synaptic active zone assembly|up-regulation of pre-synaptic active zone component assembly|up-regulation of pre-synaptic active zone component formation|up-regulation of pre-synaptic active zone formation|up-regulation of presynaptic active zone assembly|up-regulation of presynaptic active zone formation|upregulation of pre-synaptic active zone assembly|upregulation of pre-synaptic active zone component assembly|upregulation of pre-synaptic active zone component formation|upregulation of pre-synaptic active zone formation|upregulation of presynaptic active zone assembly|upregulation of presynaptic active zone formation http://purl.obolibrary.org/obo/GO_1905520 GO:1905510 biolink:BiologicalProcess negative regulation of myosin II filament assembly Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament assembly. go.json down regulation of myosin II filament assembly|down regulation of myosin II polymerization|down-regulation of myosin II filament assembly|down-regulation of myosin II polymerization|downregulation of myosin II filament assembly|downregulation of myosin II polymerization|inhibition of myosin II filament assembly|inhibition of myosin II polymerization|negative regulation of myosin II polymerization http://purl.obolibrary.org/obo/GO_1905510 GO:1905511 biolink:BiologicalProcess positive regulation of myosin II filament assembly Any process that activates or increases the frequency, rate or extent of myosin II filament assembly. go.json activation of myosin II filament assembly|activation of myosin II polymerization|positive regulation of myosin II polymerization|up regulation of myosin II filament assembly|up regulation of myosin II polymerization|up-regulation of myosin II filament assembly|up-regulation of myosin II polymerization|upregulation of myosin II filament assembly|upregulation of myosin II polymerization http://purl.obolibrary.org/obo/GO_1905511 GO:1905512 biolink:BiologicalProcess regulation of short-term synaptic potentiation Any process that modulates the frequency, rate or extent of short-term synaptic potentiation. go.json regulation of synaptic facilitation http://purl.obolibrary.org/obo/GO_1905512 GO:1905513 biolink:BiologicalProcess negative regulation of short-term synaptic potentiation Any process that stops, prevents or reduces the frequency, rate or extent of short-term synaptic potentiation. go.json down regulation of short-term synaptic potentiation|down regulation of synaptic facilitation|down-regulation of short-term synaptic potentiation|down-regulation of synaptic facilitation|downregulation of short-term synaptic potentiation|downregulation of synaptic facilitation|inhibition of short-term synaptic potentiation|inhibition of synaptic facilitation|negative regulation of synaptic facilitation http://purl.obolibrary.org/obo/GO_1905513 GO:1905514 biolink:BiologicalProcess positive regulation of short-term synaptic potentiation Any process that activates or increases the frequency, rate or extent of short-term synaptic potentiation. go.json activation of short-term synaptic potentiation|activation of synaptic facilitation|positive regulation of synaptic facilitation|up regulation of short-term synaptic potentiation|up regulation of synaptic facilitation|up-regulation of short-term synaptic potentiation|up-regulation of synaptic facilitation|upregulation of short-term synaptic potentiation|upregulation of synaptic facilitation http://purl.obolibrary.org/obo/GO_1905514 GO:1905515 biolink:BiologicalProcess non-motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium. go.json immotile primary cilium assembly|non-motile cilium formation|nonmotile cilium assembly|nonmotile cilium formation|nonmotile primary cilia assembly|nonmotile primary cilium assembly|sensory cilium assembly|sensory cilium biogenesis http://purl.obolibrary.org/obo/GO_1905515 GO:1905516 biolink:BiologicalProcess positive regulation of fertilization Any process that activates or increases the frequency, rate or extent of fertilization. go.json activation of fertilization|activation of syngamy|positive regulation of syngamy|up regulation of fertilization|up regulation of syngamy|up-regulation of fertilization|up-regulation of syngamy|upregulation of fertilization|upregulation of syngamy http://purl.obolibrary.org/obo/GO_1905516 GO:1905517 biolink:BiologicalProcess macrophage migration The orderly movement of a macrophage from one site to another. go.json http://purl.obolibrary.org/obo/GO_1905517 GO:1905518 biolink:BiologicalProcess regulation of presynaptic active zone assembly Any process that modulates the frequency, rate or extent of presynaptic active zone assembly. go.json regulation of pre-synaptic active zone assembly|regulation of pre-synaptic active zone component assembly|regulation of pre-synaptic active zone component formation|regulation of pre-synaptic active zone formation|regulation of presynaptic active zone formation http://purl.obolibrary.org/obo/GO_1905518 GO:1905519 biolink:BiologicalProcess negative regulation of presynaptic active zone assembly Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic active zone assembly. go.json down regulation of pre-synaptic active zone assembly|down regulation of pre-synaptic active zone component assembly|down regulation of pre-synaptic active zone component formation|down regulation of pre-synaptic active zone formation|down regulation of presynaptic active zone assembly|down regulation of presynaptic active zone formation|down-regulation of pre-synaptic active zone assembly|down-regulation of pre-synaptic active zone component assembly|down-regulation of pre-synaptic active zone component formation|down-regulation of pre-synaptic active zone formation|down-regulation of presynaptic active zone assembly|down-regulation of presynaptic active zone formation|downregulation of pre-synaptic active zone assembly|downregulation of pre-synaptic active zone component assembly|downregulation of pre-synaptic active zone component formation|downregulation of pre-synaptic active zone formation|downregulation of presynaptic active zone assembly|downregulation of presynaptic active zone formation|inhibition of pre-synaptic active zone assembly|inhibition of pre-synaptic active zone component assembly|inhibition of pre-synaptic active zone component formation|inhibition of pre-synaptic active zone formation|inhibition of presynaptic active zone assembly|inhibition of presynaptic active zone formation|negative regulation of pre-synaptic active zone assembly|negative regulation of pre-synaptic active zone component assembly|negative regulation of pre-synaptic active zone component formation|negative regulation of pre-synaptic active zone formation|negative regulation of presynaptic active zone formation http://purl.obolibrary.org/obo/GO_1905519 GO:0051100 biolink:BiologicalProcess negative regulation of binding Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. go.json down regulation of binding|down-regulation of binding|downregulation of binding|inhibition of binding http://purl.obolibrary.org/obo/GO_0051100 gocheck_do_not_annotate GO:0051101 biolink:BiologicalProcess regulation of DNA binding Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). go.json http://purl.obolibrary.org/obo/GO_0051101 gocheck_do_not_annotate GO:0002188 biolink:BiologicalProcess translation reinitiation A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon. go.json http://purl.obolibrary.org/obo/GO_0002188 GO:0002189 biolink:CellularComponent ribose phosphate diphosphokinase complex A protein complex having ribose phosphate diphosphokinase activity. go.json PRPP synthetase complex|phosphoribosylpyrophosphate synthetase complex http://purl.obolibrary.org/obo/GO_0002189 GO:0099098 biolink:BiologicalProcess microtubule polymerization based movement The movement of a cellular component as a result of microtubule polymerization. go.json http://purl.obolibrary.org/obo/GO_0099098 GO:0099099 biolink:MolecularActivity G-protein gated monoatomic ion channel activity An ion channel activity that is gated by binding of a G-protein beta-gamma dimer. go.json G-protein gated ion channel activity http://purl.obolibrary.org/obo/GO_0099099 GO:0002184 biolink:BiologicalProcess cytoplasmic translational termination The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon. go.json http://purl.obolibrary.org/obo/GO_0002184 GO:0099096 biolink:CellularComponent vestibular calyx terminal The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell. go.json http://purl.obolibrary.org/obo/GO_0099096 GO:0002185 biolink:CellularComponent creatine kinase complex A protein complex having creatine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0002185 GO:0099097 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099097 GO:0099094 biolink:MolecularActivity ligand-gated monoatomic cation channel activity Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. go.json ligand-gated cation channel activity http://purl.obolibrary.org/obo/GO_0099094 GO:0002186 biolink:CellularComponent cytosolic creatine kinase complex A dimeric protein complex having creatine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0002186 GO:0099095 biolink:MolecularActivity ligand-gated monoatomic anion channel activity Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. go.json ligand-gated anion channel activity http://purl.obolibrary.org/obo/GO_0099095 GO:0002187 biolink:CellularComponent mitochondrial creatine kinase complex An octomeric protein complex having creatine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0002187 GO:0099092 biolink:CellularComponent postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. go.json http://purl.obolibrary.org/obo/GO_0099092 goslim_synapse GO:0002180 biolink:CellularComponent 5-lipoxygenase complex An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity. go.json http://purl.obolibrary.org/obo/GO_0002180 GO:0002181 biolink:BiologicalProcess cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. go.json http://purl.obolibrary.org/obo/GO_0002181 goslim_generic|goslim_pombe|goslim_yeast GO:0099093 biolink:BiologicalProcess calcium export from the mitochondrion A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol. go.json calcium ion transmembrane export from mitochondrion|mitochondrial calcium ion export|mitochondrial calcium release http://purl.obolibrary.org/obo/GO_0099093 GO:0002182 biolink:BiologicalProcess cytoplasmic translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0002182 GO:0099090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0099090 GO:0099091 biolink:CellularComponent postsynaptic specialization, intracellular component A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. go.json http://purl.obolibrary.org/obo/GO_0099091 goslim_synapse GO:0002183 biolink:BiologicalProcess cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. go.json http://purl.obolibrary.org/obo/GO_0002183 GO:0002190 biolink:BiologicalProcess cap-independent translational initiation The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation. go.json http://purl.obolibrary.org/obo/GO_0002190 GO:0002199 biolink:CellularComponent zona pellucida receptor complex A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction. go.json sperm protein complex I http://purl.obolibrary.org/obo/GO_0002199 GO:0002195 biolink:BiologicalProcess 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs. go.json http://purl.obolibrary.org/obo/GO_0002195 GO:0002196 biolink:MolecularActivity Ser-tRNA(Ala) hydrolase activity Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala). go.json http://purl.obolibrary.org/obo/GO_0002196 GO:0002197 biolink:CellularComponent xanthine dehydrogenase complex A homodimeric protein complex having xanthine dehydrogenase activity. go.json http://purl.obolibrary.org/obo/GO_0002197 GO:0002198 biolink:BiologicalProcess obsolete S/G2 transition of mitotic cell cycle OBSOLETE. The transition from a cell in the S phase to the G2 phase. go.json S/G2 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0002198 GO:0002191 biolink:BiologicalProcess cap-dependent translational initiation The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation. go.json http://purl.obolibrary.org/obo/GO_0002191 GO:0002192 biolink:BiologicalProcess IRES-dependent translational initiation of linear mRNA The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation. go.json http://purl.obolibrary.org/obo/GO_0002192 GO:0002193 biolink:CellularComponent MAML1-RBP-Jkappa- ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML1-CSL-ICN1|MAML1-CSL-Notch1 complex|MAML1-RBP-Jkappa-Notch1 complex http://purl.obolibrary.org/obo/GO_0002193 GO:0002194 biolink:BiologicalProcess hepatocyte cell migration The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes. go.json http://purl.obolibrary.org/obo/GO_0002194 GO:0099078 biolink:CellularComponent BORC complex A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors. go.json http://purl.obolibrary.org/obo/GO_0099078 GO:0002166 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002166 GO:0002167 biolink:CellularComponent VRK3/VHR/ERK complex A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0002167 GO:0099079 biolink:CellularComponent actin body An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin. go.json http://purl.obolibrary.org/obo/GO_0099079 GO:0002168 biolink:BiologicalProcess instar larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0002168 GO:0099076 biolink:BiologicalProcess mitochondrion to peroxisome transport Transport from the mitochondrion to the peroxisome, mediated by mitochondrion-derived vesicles. go.json http://purl.obolibrary.org/obo/GO_0099076 GO:0002169 biolink:CellularComponent 3-methylcrotonyl-CoA carboxylase complex, mitochondrial A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. go.json mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme|mitochondrial MCCC complex|mitochondrial methylcrotonoyl-CoA carboxylase complex http://purl.obolibrary.org/obo/GO_0002169 GO:0099077 biolink:MolecularActivity histone-dependent DNA binding DNA-binding activity that is dependent on binding to a histone. go.json http://purl.obolibrary.org/obo/GO_0099077 GO:0002162 biolink:MolecularActivity dystroglycan binding Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). go.json alpha-dystroglycan binding|beta-dystroglycan binding http://purl.obolibrary.org/obo/GO_0002162 GO:0099074 biolink:BiologicalProcess mitochondrion to lysosome transport Transport from the mitochondrion to the lysosome, mediated by mitochondrion-derived vesicles. go.json http://purl.obolibrary.org/obo/GO_0099074 GO:0099075 biolink:BiologicalProcess mitochondrion-derived vesicle mediated transport Transport from the mitochondrion, mediated by mitochondrion derived vesicles. go.json http://purl.obolibrary.org/obo/GO_0099075 GO:0002163 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002163 GO:0099072 biolink:BiologicalProcess regulation of postsynaptic membrane neurotransmitter receptor levels Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. go.json http://purl.obolibrary.org/obo/GO_0099072 goslim_synapse GO:0002164 biolink:BiologicalProcess larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. go.json http://purl.obolibrary.org/obo/GO_0002164 GO:0099073 biolink:CellularComponent mitochondrion-derived vesicle A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae. go.json MDV http://purl.obolibrary.org/obo/GO_0099073 GO:0002165 biolink:BiologicalProcess instar larval or pupal development The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0002165 GO:0099070 biolink:CellularComponent static microtubule bundle A microtubule bundle that has a constant length, and in which microtubule sliding does not take place. go.json Q-MT bundle|quiescent cell MT bundle|quiescent cell microtubule bundle http://purl.obolibrary.org/obo/GO_0099070 GO:0099071 biolink:CellularComponent dynamic microtubule bundle A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place. go.json http://purl.obolibrary.org/obo/GO_0099071 GO:0002160 biolink:BiologicalProcess desmosome maintenance The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0002160 GO:0002161 biolink:MolecularActivity aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA. go.json amino acid proofreading activity|aminoacyl-tRNA hydrolysis activity http://purl.obolibrary.org/obo/GO_0002161 GO:0002177 biolink:CellularComponent manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments. go.json http://purl.obolibrary.org/obo/GO_0002177 GO:0099089 biolink:BiologicalProcess establishment of endoplasmic reticulum localization to postsynapse The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine. go.json establishment of ER localization to postsynapse http://purl.obolibrary.org/obo/GO_0099089 goslim_synapse GO:0002178 biolink:CellularComponent palmitoyltransferase complex A protein complex with palmitoyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0002178 GO:0099087 biolink:BiologicalProcess anterograde axonal transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse. go.json anterograde axonal transport of mRNA RNP complex http://purl.obolibrary.org/obo/GO_0099087 goslim_synapse GO:0002179 biolink:CellularComponent homodimeric serine palmitoyltransferase complex A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine. go.json http://purl.obolibrary.org/obo/GO_0002179 GO:0099088 biolink:BiologicalProcess axonal transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in axons. go.json axonal transport of mRNA RNP complex http://purl.obolibrary.org/obo/GO_0099088 goslim_synapse GO:0099085 biolink:MolecularActivity DIF dechlorinase activity Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-. go.json 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity|1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity|DIF-1 3(5)-dechlorinase activity|DIF-1 dechlorinase activity|differentiation-inducing factor 1 dechlorinase activity|differentiation-inducing factor dechlorinase activity http://purl.obolibrary.org/obo/GO_0099085 GO:0002173 biolink:MolecularActivity low-affinity IgM receptor activity Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json low affinity IgM receptor activity http://purl.obolibrary.org/obo/GO_0002173 GO:0002174 biolink:BiologicalProcess mammary stem cell proliferation The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ. go.json http://purl.obolibrary.org/obo/GO_0002174 GO:0099086 biolink:CellularComponent synaptonemal structure A proteinaceous scaffold found between homologous chromosomes during meiosis. go.json http://purl.obolibrary.org/obo/GO_0099086 GO:0002175 biolink:BiologicalProcess protein localization to paranode region of axon A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon. go.json protein localisation to paranode region of axon http://purl.obolibrary.org/obo/GO_0002175 GO:0099083 biolink:BiologicalProcess retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. go.json http://purl.obolibrary.org/obo/GO_0099083 goslim_synapse GO:0002176 biolink:BiologicalProcess male germ cell proliferation The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0002176 GO:0099084 biolink:BiologicalProcess postsynaptic specialization organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane. go.json post synaptic specialization organization|post-synaptic specialization organization|postsynaptic specialization organisation http://purl.obolibrary.org/obo/GO_0099084 goslim_synapse GO:0099081 biolink:CellularComponent supramolecular polymer A polymeric supramolecular structure. go.json http://purl.obolibrary.org/obo/GO_0099081 GO:0099082 biolink:BiologicalProcess retrograde trans-synaptic signaling by neuropeptide Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. go.json http://purl.obolibrary.org/obo/GO_0099082 goslim_synapse GO:0002170 biolink:MolecularActivity high-affinity IgA receptor activity Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json high affinity IgA receptor activity http://purl.obolibrary.org/obo/GO_0002170 GO:0002171 biolink:MolecularActivity low-affinity IgA receptor activity Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json low affinity IgA receptor activity http://purl.obolibrary.org/obo/GO_0002171 GO:0099080 biolink:CellularComponent supramolecular complex A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. go.json http://purl.obolibrary.org/obo/GO_0099080 GO:0002172 biolink:MolecularActivity high-affinity IgM receptor activity Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json high affinity IgM receptor activity http://purl.obolibrary.org/obo/GO_0002172 GO:0002148 biolink:BiologicalProcess hypochlorous acid metabolic process The chemical reactions and pathways involving hypochlorous acid. go.json HClO metabolic process|HOCl metabolic process|hypochlorite metabolic process|hypochlorous acid metabolism http://purl.obolibrary.org/obo/GO_0002148 GO:0002149 biolink:BiologicalProcess hypochlorous acid biosynthetic process The chemical reactions and pathways resulting in the formation of hypochlorous acid. go.json HClO biosynthetic process|HOCl biosynthetic process|hypochlorite biosynthetic process|hypochlorous acid biosynthesis http://purl.obolibrary.org/obo/GO_0002149 GO:0002144 biolink:CellularComponent cytosolic tRNA wobble base thiouridylase complex A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets. go.json Ctu1-Ctu2 complex|tRNA thiouridylase http://purl.obolibrary.org/obo/GO_0002144 GO:0002145 biolink:MolecularActivity 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+. MetaCyc:RXN0-3543|RHEA:27914 go.json HMP-PP diphosphatase|HMP-PP pyrophosphatase http://purl.obolibrary.org/obo/GO_0002145 GO:0002146 biolink:BiologicalProcess obsolete steroid hormone receptor import into nucleus OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus. go.json steroid hormone receptor nuclear translocation True http://purl.obolibrary.org/obo/GO_0002146 GO:0002147 biolink:BiologicalProcess obsolete glucocorticoid receptor import into nucleus OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus. go.json glucocorticoid receptor nuclear translocation True http://purl.obolibrary.org/obo/GO_0002147 GO:0002140 biolink:CellularComponent stereocilia tip link A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia. go.json http://purl.obolibrary.org/obo/GO_0002140 GO:0002141 biolink:CellularComponent stereocilia ankle link A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia. go.json http://purl.obolibrary.org/obo/GO_0002141 GO:0002142 biolink:CellularComponent stereocilia ankle link complex A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin. go.json http://purl.obolibrary.org/obo/GO_0002142 GO:0002143 biolink:BiologicalProcess tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. go.json tRNA wobble uridine thiolation|wobble position s2U biosynthesis http://purl.obolibrary.org/obo/GO_0002143 GO:0016789 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016789 GO:0016785 biolink:MolecularActivity selenotransferase activity Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor). EC:2.9.1.- go.json transferase activity, transferring selenium-containing groups http://purl.obolibrary.org/obo/GO_0016785 GO:0016786 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016786 GO:0016787 biolink:MolecularActivity hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. EC:3.-.-.-|Reactome:R-HSA-1236938|Reactome:R-HSA-2029475|Reactome:R-HSA-5694583|Reactome:R-HSA-5695964|Reactome:R-HSA-6786190|Reactome:R-HSA-6788295|Reactome:R-HSA-8938314|Reactome:R-HSA-8952137 go.json http://purl.obolibrary.org/obo/GO_0016787 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0016788 biolink:MolecularActivity hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond. EC:3.1.-.-|Reactome:R-HSA-162729|Reactome:R-HSA-9023617|Reactome:R-HSA-9023619|Reactome:R-HSA-9749609 go.json esterase activity http://purl.obolibrary.org/obo/GO_0016788 goslim_chembl GO:0016781 biolink:MolecularActivity phosphotransferase activity, paired acceptors Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. EC:2.7.9.- go.json http://purl.obolibrary.org/obo/GO_0016781 GO:0016782 biolink:MolecularActivity transferase activity, transferring sulphur-containing groups Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). EC:2.8.-.- go.json http://purl.obolibrary.org/obo/GO_0016782 GO:0016783 biolink:MolecularActivity sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). EC:2.8.1.-|Reactome:R-HSA-1614618|Reactome:R-HSA-6782264|Reactome:R-HSA-947538 go.json sulphurtransferase activity http://purl.obolibrary.org/obo/GO_0016783 GO:0016784 biolink:MolecularActivity 3-mercaptopyruvate sulfurtransferase activity Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. EC:2.8.1.2|MetaCyc:MERCAPYSTRANS-RXN|RHEA:21740|Reactome:R-HSA-9012721|Reactome:R-HSA-9013471|Reactome:R-HSA-9013533|Reactome:R-HSA-9034756 go.json 3-mercaptopyruvate sulphurtransferase activity|3-mercaptopyruvate:cyanide sulfurtransferase activity|beta-mercaptopyruvate sulfurtransferase activity|mercaptopyruvate sulfurtransferase activity http://purl.obolibrary.org/obo/GO_0016784 GO:0016780 biolink:MolecularActivity phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). EC:2.7.8.-|Reactome:R-HSA-162742|Reactome:R-HSA-163069 go.json http://purl.obolibrary.org/obo/GO_0016780 GO:0002159 biolink:BiologicalProcess desmosome assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0002159 GO:0002155 biolink:BiologicalProcess regulation of thyroid hormone mediated signaling pathway Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway. go.json regulation of thyroid hormone mediated signalling pathway http://purl.obolibrary.org/obo/GO_0002155 GO:0002156 biolink:BiologicalProcess negative regulation of thyroid hormone mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway. go.json negative regulation of thyroid hormone mediated signalling pathway http://purl.obolibrary.org/obo/GO_0002156 GO:0002157 biolink:BiologicalProcess positive regulation of thyroid hormone mediated signaling pathway Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway. go.json positive regulation of thyroid hormone mediated signalling pathway http://purl.obolibrary.org/obo/GO_0002157 GO:0002158 biolink:BiologicalProcess osteoclast proliferation The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. go.json http://purl.obolibrary.org/obo/GO_0002158 GO:0002151 biolink:MolecularActivity G-quadruplex RNA binding Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. Reactome:R-HSA-9836998 go.json G quadruplex binding|G quartet RNA binding|G quartet binding|G-quartet binding http://purl.obolibrary.org/obo/GO_0002151 GO:0002152 biolink:BiologicalProcess bile acid conjugation The process in which bile acids are covalently linked to taurine or glycine. go.json http://purl.obolibrary.org/obo/GO_0002152 GO:0002153 biolink:MolecularActivity steroid receptor RNA activator RNA binding Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding. go.json SRA binding http://purl.obolibrary.org/obo/GO_0002153 GO:0002154 biolink:BiologicalProcess thyroid hormone mediated signaling pathway The series of molecular signals mediated by the detection of a thyroid hormone. go.json thyroid hormone mediated signalling pathway http://purl.obolibrary.org/obo/GO_0002154 GO:0002150 biolink:BiologicalProcess hypochlorous acid catabolic process The chemical reactions and pathways resulting in the breakdown of hypochlorous acid. go.json HClO catabolic process|HOCl catabolic process|hypochlorite catabolic process|hypochlorous acid catabolism http://purl.obolibrary.org/obo/GO_0002150 GO:0016796 biolink:MolecularActivity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. EC:3.1.15.- go.json exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters http://purl.obolibrary.org/obo/GO_0016796 GO:0016797 biolink:MolecularActivity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. EC:3.1.16.- go.json http://purl.obolibrary.org/obo/GO_0016797 GO:0016798 biolink:MolecularActivity hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond. EC:3.2.-.-|Reactome:R-HSA-1793176|Reactome:R-HSA-2065233 go.json N-glycosylase|glycosidase activity|glycosylase http://purl.obolibrary.org/obo/GO_0016798 goslim_chembl|goslim_drosophila|goslim_yeast GO:0016799 biolink:MolecularActivity hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond. EC:3.2.2.- go.json http://purl.obolibrary.org/obo/GO_0016799 GO:0016792 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016792 GO:0016793 biolink:MolecularActivity triphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. EC:3.1.5.-|Reactome:R-HSA-8866601 go.json http://purl.obolibrary.org/obo/GO_0016793 GO:0016794 biolink:MolecularActivity diphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. EC:3.1.7.- go.json http://purl.obolibrary.org/obo/GO_0016794 GO:0016795 biolink:MolecularActivity phosphoric triester hydrolase activity Catalysis of the hydrolysis of a phosphoric triester. EC:3.1.8.- go.json http://purl.obolibrary.org/obo/GO_0016795 GO:0016790 biolink:MolecularActivity thiolester hydrolase activity Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. EC:3.1.2.- go.json thiolesterase activity http://purl.obolibrary.org/obo/GO_0016790 GO:0016791 biolink:MolecularActivity phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. EC:3.1.3.-|Reactome:R-HSA-4419986|Reactome:R-HSA-9636457|Reactome:R-HSA-9837419 go.json phosphatase|phosphoric monoester hydrolase activity http://purl.obolibrary.org/obo/GO_0016791 goslim_candida|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_yeast GO:0002126 biolink:BiologicalProcess instrumental aggressive behavior Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation. go.json instrumental aggression http://purl.obolibrary.org/obo/GO_0002126 GO:0002127 biolink:BiologicalProcess tRNA wobble base cytosine methylation The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position. go.json wobble position m5C biosynthesis http://purl.obolibrary.org/obo/GO_0002127 GO:0002128 biolink:BiologicalProcess tRNA nucleoside ribose methylation The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position. go.json http://purl.obolibrary.org/obo/GO_0002128 GO:0002129 biolink:BiologicalProcess wobble position guanine ribose methylation The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. go.json http://purl.obolibrary.org/obo/GO_0002129 GO:0002122 biolink:BiologicalProcess fear-induced aggressive behavior Aggressive behavior associated with attempts to flee from a threat. go.json fear-induced aggression http://purl.obolibrary.org/obo/GO_0002122 GO:0002123 biolink:BiologicalProcess irritable aggressive behavior Aggressive behavior induced by frustration and directed against an available target. go.json irritable aggression http://purl.obolibrary.org/obo/GO_0002123 GO:0002124 biolink:BiologicalProcess territorial aggressive behavior Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics. go.json territorial aggression http://purl.obolibrary.org/obo/GO_0002124 GO:0002125 biolink:BiologicalProcess maternal aggressive behavior Aggressive behavior of a female to protect her offspring from a threat. go.json maternal aggression http://purl.obolibrary.org/obo/GO_0002125 GO:0002120 biolink:BiologicalProcess obsolete predatory behavior OBSOLETE. Aggressive behavior involving attack on prey by a predator. go.json predatory aggression|predatory aggressive behavior True http://purl.obolibrary.org/obo/GO_0002120 GO:0002121 biolink:BiologicalProcess inter-male aggressive behavior Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious. go.json inter-male aggression http://purl.obolibrary.org/obo/GO_0002121 GO:0016767 biolink:MolecularActivity geranylgeranyl-diphosphate geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate. EC:2.5.1.32|MetaCyc:2.5.1.32-RXN|RHEA:22296 go.json PSase activity|geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity|phytoene synthetase activity|prephytoene-diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0016767 GO:0016768 biolink:MolecularActivity spermine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. EC:2.5.1.22|MetaCyc:SPERMINE-SYNTHASE-RXN|RHEA:19973|Reactome:R-HSA-351210 go.json S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity|spermidine aminopropyltransferase activity|spermine synthetase activity http://purl.obolibrary.org/obo/GO_0016768 GO:0016769 biolink:MolecularActivity transferase activity, transferring nitrogenous groups Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). EC:2.6.-.- go.json transferase activity, transferring other nitrogenous groups http://purl.obolibrary.org/obo/GO_0016769 GO:0016763 biolink:MolecularActivity pentosyltransferase activity Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). EC:2.4.2.-|Reactome:R-HSA-112265|Reactome:R-HSA-112266 go.json transferase activity, transferring pentosyl groups http://purl.obolibrary.org/obo/GO_0016763 GO:0016764 biolink:MolecularActivity obsolete transferase activity, transferring other glycosyl groups OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor). go.json transferase activity, transferring other glycosyl groups True http://purl.obolibrary.org/obo/GO_0016764 GO:0016765 biolink:MolecularActivity transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). EC:2.5.1.-|Reactome:R-HSA-3159253|Reactome:R-HSA-4419978|Reactome:R-HSA-4755545|Reactome:R-HSA-6782893 go.json transferase activity, transferring alkyl or aryl groups, other than methyl groups http://purl.obolibrary.org/obo/GO_0016765 goslim_chembl|goslim_drosophila GO:0016766 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016766 GO:0016760 biolink:MolecularActivity cellulose synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1). EC:2.4.1.12|MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN|RHEA:19929 go.json 1,4-beta-D-glucan synthase activity|1,4-beta-glucan synthase activity|GS-I|UDP-glucose-1,4-beta-glucan glucosyltransferase activity|UDP-glucose-beta-D-glucan glucosyltransferase activity|UDP-glucose-cellulose glucosyltransferase activity|UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|UDPglucose-beta-glucan glucosyltransferase activity|UDPglucose-cellulose glucosyltransferase activity|UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|beta-1,4-glucan synthase activity|beta-1,4-glucan synthetase activity|beta-1,4-glucosyltransferase activity|beta-glucan synthase activity|glucan synthase activity|uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity|uridine diphosphoglucose-cellulose glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0016760 GO:0016761 biolink:MolecularActivity cellulose synthase (GDP-forming) activity Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1). EC:2.4.1.29|MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN|RHEA:17797 go.json GDP-glucose-beta-D-glucan glucosyltransferase activity|GDP-glucose-cellulose glucosyltransferase activity|GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|cellulose synthase (guanosine diphosphate-forming) activity|guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity|guanosine diphosphoglucose-cellulose glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0016761 GO:0016762 biolink:MolecularActivity xyloglucan:xyloglucosyl transferase activity Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. EC:2.4.1.207|MetaCyc:2.4.1.207-RXN go.json endo-xyloglucan transferase activity|endoxyloglucan transferase activity|xyloglucan endotransglucosylase activity|xyloglucan:xyloglucan xyloglucanotransferase activity http://purl.obolibrary.org/obo/GO_0016762 GO:0002137 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002137 GO:0002138 biolink:BiologicalProcess retinoic acid biosynthetic process The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A. go.json retinoic acid anabolic process|retinoic acid biosynthesis http://purl.obolibrary.org/obo/GO_0002138 GO:0002139 biolink:CellularComponent stereocilia coupling link A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle. go.json http://purl.obolibrary.org/obo/GO_0002139 GO:0002133 biolink:CellularComponent polycystin complex A stable heterodimeric complex composed of polycystin-1 and polycystin-2. go.json http://purl.obolibrary.org/obo/GO_0002133 GO:0002134 biolink:MolecularActivity UTP binding Binding to UTP, uridine 5'-triphosphate. go.json http://purl.obolibrary.org/obo/GO_0002134 GO:0002135 biolink:MolecularActivity CTP binding Binding to CTP, cytidine 5'-triphosphate. go.json http://purl.obolibrary.org/obo/GO_0002135 GO:0002136 biolink:BiologicalProcess tRNA wobble base lysidine biosynthesis The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine. go.json http://purl.obolibrary.org/obo/GO_0002136 GO:0002130 biolink:BiologicalProcess wobble position ribose methylation The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position. go.json http://purl.obolibrary.org/obo/GO_0002130 GO:0002131 biolink:BiologicalProcess wobble position cytosine ribose methylation The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. go.json http://purl.obolibrary.org/obo/GO_0002131 GO:0002132 biolink:BiologicalProcess wobble position uridine ribose methylation The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. go.json http://purl.obolibrary.org/obo/GO_0002132 GO:0016778 biolink:MolecularActivity diphosphotransferase activity Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). EC:2.7.6.- go.json http://purl.obolibrary.org/obo/GO_0016778 GO:0016779 biolink:MolecularActivity nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant. EC:2.7.7.-|Reactome:R-HSA-6782434 go.json http://purl.obolibrary.org/obo/GO_0016779 goslim_candida|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_yeast GO:0016774 biolink:MolecularActivity phosphotransferase activity, carboxyl group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). EC:2.7.2.- go.json http://purl.obolibrary.org/obo/GO_0016774 GO:0016775 biolink:MolecularActivity phosphotransferase activity, nitrogenous group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). EC:2.7.3.- go.json http://purl.obolibrary.org/obo/GO_0016775 GO:0016776 biolink:MolecularActivity phosphotransferase activity, phosphate group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). EC:2.7.4.- go.json http://purl.obolibrary.org/obo/GO_0016776 GO:0016777 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016777 GO:0016770 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016770 GO:0016771 biolink:MolecularActivity obsolete transferase activity, transferring other nitrogenous groups OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor). go.json transferase activity, transferring other nitrogenous groups True http://purl.obolibrary.org/obo/GO_0016771 GO:0016772 biolink:MolecularActivity transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). EC:2.7.-.- go.json http://purl.obolibrary.org/obo/GO_0016772 goslim_chembl GO:0016773 biolink:MolecularActivity phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). EC:2.7.1.-|Reactome:R-HSA-2161193 go.json http://purl.obolibrary.org/obo/GO_0016773 goslim_drosophila GO:1905490 biolink:BiologicalProcess negative regulation of sensory neuron axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of sensory neuron axon guidance. go.json down regulation of sensory neuron axon guidance|down-regulation of sensory neuron axon guidance|downregulation of sensory neuron axon guidance|inhibition of sensory neuron axon guidance http://purl.obolibrary.org/obo/GO_1905490 GO:1905491 biolink:BiologicalProcess positive regulation of sensory neuron axon guidance Any process that activates or increases the frequency, rate or extent of sensory neuron axon guidance. go.json activation of sensory neuron axon guidance|up regulation of sensory neuron axon guidance|up-regulation of sensory neuron axon guidance|upregulation of sensory neuron axon guidance http://purl.obolibrary.org/obo/GO_1905491 GO:1905492 biolink:BiologicalProcess positive regulation of branching morphogenesis of a nerve Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. go.json activation of branching morphogenesis of a nerve|up regulation of branching morphogenesis of a nerve|up-regulation of branching morphogenesis of a nerve|upregulation of branching morphogenesis of a nerve http://purl.obolibrary.org/obo/GO_1905492 GO:1905493 biolink:BiologicalProcess regulation of G-quadruplex DNA binding Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding. go.json regulation of G quadruplex DNA binding|regulation of G quartet DNA binding|regulation of G quartet binding|regulation of G-DNA binding|regulation of G-quartet DNA binding|regulation of G-quartet binding|regulation of quadruplex DNA binding|regulation of tetraplex DNA binding http://purl.obolibrary.org/obo/GO_1905493 gocheck_do_not_annotate GO:1905494 biolink:BiologicalProcess negative regulation of G-quadruplex DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding. go.json down regulation of G quadruplex DNA binding|down regulation of G quartet DNA binding|down regulation of G-DNA binding|down regulation of G-quadruplex DNA binding|down regulation of G-quartet DNA binding|down regulation of quadruplex DNA binding|down regulation of tetraplex DNA binding|down-regulation of G quadruplex DNA binding|down-regulation of G quartet DNA binding|down-regulation of G-DNA binding|down-regulation of G-quadruplex DNA binding|down-regulation of G-quartet DNA binding|down-regulation of quadruplex DNA binding|down-regulation of tetraplex DNA binding|downregulation of G quadruplex DNA binding|downregulation of G quartet DNA binding|downregulation of G-DNA binding|downregulation of G-quadruplex DNA binding|downregulation of G-quartet DNA binding|downregulation of quadruplex DNA binding|downregulation of tetraplex DNA binding|inhibition of G quadruplex DNA binding|inhibition of G quartet DNA binding|inhibition of G-DNA binding|inhibition of G-quadruplex DNA binding|inhibition of G-quartet DNA binding|inhibition of quadruplex DNA binding|inhibition of tetraplex DNA binding|negative regulation of G quadruplex DNA binding|negative regulation of G quartet DNA binding|negative regulation of G-DNA binding|negative regulation of G-quartet DNA binding|negative regulation of quadruplex DNA binding|negative regulation of tetraplex DNA binding http://purl.obolibrary.org/obo/GO_1905494 gocheck_do_not_annotate GO:1905495 biolink:BiologicalProcess positive regulation of G-quadruplex DNA binding Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA binding. go.json activation of G quadruplex DNA binding|activation of G quartet DNA binding|activation of G-DNA binding|activation of G-quadruplex DNA binding|activation of G-quartet DNA binding|activation of quadruplex DNA binding|activation of tetraplex DNA binding|positive regulation of G quadruplex DNA binding|positive regulation of G quartet DNA binding|positive regulation of G-DNA binding|positive regulation of G-quartet DNA binding|positive regulation of quadruplex DNA binding|positive regulation of tetraplex DNA binding|up regulation of G quadruplex DNA binding|up regulation of G quartet DNA binding|up regulation of G-DNA binding|up regulation of G-quadruplex DNA binding|up regulation of G-quartet DNA binding|up regulation of quadruplex DNA binding|up regulation of tetraplex DNA binding|up-regulation of G quadruplex DNA binding|up-regulation of G quartet DNA binding|up-regulation of G-DNA binding|up-regulation of G-quadruplex DNA binding|up-regulation of G-quartet DNA binding|up-regulation of quadruplex DNA binding|up-regulation of tetraplex DNA binding|upregulation of G quadruplex DNA binding|upregulation of G quartet DNA binding|upregulation of G-DNA binding|upregulation of G-quadruplex DNA binding|upregulation of G-quartet DNA binding|upregulation of quadruplex DNA binding|upregulation of tetraplex DNA binding http://purl.obolibrary.org/obo/GO_1905495 gocheck_do_not_annotate GO:1905496 biolink:BiologicalProcess regulation of triplex DNA binding Any process that modulates the frequency, rate or extent of triplex DNA binding. go.json http://purl.obolibrary.org/obo/GO_1905496 gocheck_do_not_annotate GO:1905497 biolink:BiologicalProcess negative regulation of triplex DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding. go.json down regulation of triplex DNA binding|down-regulation of triplex DNA binding|downregulation of triplex DNA binding|inhibition of triplex DNA binding http://purl.obolibrary.org/obo/GO_1905497 gocheck_do_not_annotate GO:1905498 biolink:BiologicalProcess positive regulation of triplex DNA binding Any process that activates or increases the frequency, rate or extent of triplex DNA binding. go.json activation of triplex DNA binding|up regulation of triplex DNA binding|up-regulation of triplex DNA binding|upregulation of triplex DNA binding http://purl.obolibrary.org/obo/GO_1905498 gocheck_do_not_annotate GO:1905488 biolink:BiologicalProcess positive regulation of anterior/posterior axon guidance Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance. go.json activation of anterior-posterior axon guidance|activation of anterior/posterior axon guidance|activation of anterior/posterior axon pathfinding|positive regulation of anterior-posterior axon guidance|positive regulation of anterior/posterior axon pathfinding|up regulation of anterior-posterior axon guidance|up regulation of anterior/posterior axon guidance|up regulation of anterior/posterior axon pathfinding|up-regulation of anterior-posterior axon guidance|up-regulation of anterior/posterior axon guidance|up-regulation of anterior/posterior axon pathfinding|upregulation of anterior-posterior axon guidance|upregulation of anterior/posterior axon guidance|upregulation of anterior/posterior axon pathfinding http://purl.obolibrary.org/obo/GO_1905488 GO:1905489 biolink:BiologicalProcess regulation of sensory neuron axon guidance Any process that modulates the frequency, rate or extent of sensory neuron axon guidance. go.json http://purl.obolibrary.org/obo/GO_1905489 GO:0075280 biolink:BiologicalProcess regulation of uredinium development Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. go.json http://purl.obolibrary.org/obo/GO_0075280 GO:0075281 biolink:BiologicalProcess positive regulation of uredinium development Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. go.json http://purl.obolibrary.org/obo/GO_0075281 GO:0075282 biolink:BiologicalProcess negative regulation of uredinium development Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. go.json http://purl.obolibrary.org/obo/GO_0075282 GO:0075283 biolink:BiologicalProcess sporulation resulting in formation of a multicellular or syncytial spore The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure. go.json multicellular or syncytial spore formation by sporulation http://purl.obolibrary.org/obo/GO_0075283 GO:0075284 biolink:BiologicalProcess asexual sporulation resulting in formation of a multicellular or syncytial spore The formation of a multicellular or syncytial spore via septations derived from mitosis. go.json http://purl.obolibrary.org/obo/GO_0075284 GO:0075285 biolink:BiologicalProcess sexual sporulation resulting in formation of a multicellular or syncytial spore The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. go.json http://purl.obolibrary.org/obo/GO_0075285 GO:0075286 biolink:BiologicalProcess regulation of sporangiospore formation Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0075286 GO:0075287 biolink:BiologicalProcess positive regulation of sporangiospore formation Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0075287 GO:0075288 biolink:BiologicalProcess negative regulation of sporangiospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0075288 GO:0075289 biolink:BiologicalProcess aplanospore formation The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. go.json http://purl.obolibrary.org/obo/GO_0075289 GO:1905499 biolink:BiologicalProcess trichome papilla formation The aggregation, arrangement and bonding together of a set of components to form a trichome papilla. go.json trichome papilla assembly http://purl.obolibrary.org/obo/GO_1905499 GO:0075270 biolink:BiologicalProcess negative regulation of aecium development Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed. go.json http://purl.obolibrary.org/obo/GO_0075270 GO:0075271 biolink:BiologicalProcess zygosporangium development The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes. go.json http://purl.obolibrary.org/obo/GO_0075271 GO:0075272 biolink:BiologicalProcess regulation of zygosporangium development Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed. go.json http://purl.obolibrary.org/obo/GO_0075272 GO:0075273 biolink:BiologicalProcess positive regulation of zygosporangium development Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed. go.json http://purl.obolibrary.org/obo/GO_0075273 GO:0075274 biolink:BiologicalProcess negative regulation of zygosporangium development Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed. go.json http://purl.obolibrary.org/obo/GO_0075274 GO:0075275 biolink:BiologicalProcess telium development The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi. go.json http://purl.obolibrary.org/obo/GO_0075275 GO:0075276 biolink:BiologicalProcess regulation of telium development Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi. go.json http://purl.obolibrary.org/obo/GO_0075276 GO:0075277 biolink:BiologicalProcess positive regulation of telium development Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi. go.json http://purl.obolibrary.org/obo/GO_0075277 GO:0075278 biolink:BiologicalProcess negative regulation of telium development Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi. go.json http://purl.obolibrary.org/obo/GO_0075278 GO:0075279 biolink:BiologicalProcess uredinium development The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. go.json development of uredium http://purl.obolibrary.org/obo/GO_0075279 GO:2000805 biolink:BiologicalProcess negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. go.json negative regulation of termination of RNA polymerase II transcription, polyadenylation-coupled|negative regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled|negative regulation of transcription termination from Pol II promoter, poly(A) coupled http://purl.obolibrary.org/obo/GO_2000805 GO:2000806 biolink:BiologicalProcess positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. go.json positive regulation of termination of RNA polymerase II transcription, polyadenylation-coupled|positive regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled|positive regulation of transcription termination from Pol II promoter, poly(A) coupled http://purl.obolibrary.org/obo/GO_2000806 GO:2000807 biolink:BiologicalProcess regulation of synaptic vesicle clustering Any process that modulates the frequency, rate or extent of synaptic vesicle clustering. go.json http://purl.obolibrary.org/obo/GO_2000807 GO:2000808 biolink:BiologicalProcess negative regulation of synaptic vesicle clustering Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering. go.json http://purl.obolibrary.org/obo/GO_2000808 GO:2000809 biolink:BiologicalProcess positive regulation of synaptic vesicle clustering Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering. go.json http://purl.obolibrary.org/obo/GO_2000809 GO:2000800 biolink:BiologicalProcess regulation of endocardial cushion to mesenchymal transition involved in heart valve formation Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. go.json regulation of endocardial cushion to mesenchymal transition involved in valve formation http://purl.obolibrary.org/obo/GO_2000800 GO:2000801 biolink:BiologicalProcess negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. go.json negative regulation of endocardial cushion to mesenchymal transition involved in valve formation http://purl.obolibrary.org/obo/GO_2000801 GO:2000802 biolink:BiologicalProcess positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. go.json positive regulation of endocardial cushion to mesenchymal transition involved in valve formation http://purl.obolibrary.org/obo/GO_2000802 GO:2000803 biolink:BiologicalProcess obsolete endosomal signal transduction OBSOLETE. The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction. go.json endosome-based signaling|signaling cascade in endosome|signaling from endosome|signaling pathway in endosome|signalling cascade in endosome|signalling pathway in endosome True http://purl.obolibrary.org/obo/GO_2000803 GO:2000804 biolink:BiologicalProcess regulation of termination of RNA polymerase II transcription, poly(A)-coupled Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. go.json regulation of termination of RNA polymerase II transcription, polyadenylation-coupled|regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled|regulation of transcription termination from Pol II promoter, poly(A) coupled http://purl.obolibrary.org/obo/GO_2000804 GO:2000816 biolink:BiologicalProcess negative regulation of mitotic sister chromatid separation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation. go.json negative regulation of chromosome separation during mitosis|negative regulation of mitotic chromosome separation|negative regulation of mitotic sister chromatid resolution|negative regulation of sister chromatid separation during mitosis http://purl.obolibrary.org/obo/GO_2000816 GO:2000817 biolink:BiologicalProcess obsolete regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore OBSOLETE. Any regulation of histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore. go.json regulation of histone H3-T3 phosphorylation involved in CPC complex localization to kinetochore|regulation of histone H3-T3 phosphorylation involved in CPC localization to kinetochore|regulation of histone H3-T3 phosphorylation involved in chromosomal passenger complex localization to kinetochore|regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localisation to kinetochore True http://purl.obolibrary.org/obo/GO_2000817 GO:2000818 biolink:BiologicalProcess negative regulation of myoblast proliferation Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_2000818 GO:2000819 biolink:BiologicalProcess regulation of nucleotide-excision repair Any process that modulates the frequency, rate or extent of nucleotide-excision repair. go.json regulation of NER|regulation of interstrand crosslink repair|regulation of intrastrand cross-link repair|regulation of pyrimidine-dimer repair, DNA damage excision http://purl.obolibrary.org/obo/GO_2000819 GO:0099243 biolink:CellularComponent extrinsic component of synaptic membrane The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0099243 goslim_synapse GO:0099240 biolink:CellularComponent obsolete intrinsic component of synaptic membrane OBSOLETE. The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to synaptic membrane True http://purl.obolibrary.org/obo/GO_0099240 GO:2000810 biolink:BiologicalProcess regulation of bicellular tight junction assembly Any process that modulates the frequency, rate or extent of tight junction assembly. go.json regulation of tight junction formation http://purl.obolibrary.org/obo/GO_2000810 GO:2000811 biolink:BiologicalProcess negative regulation of anoikis Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. go.json negative regulation of detachment induced cell death|negative regulation of suspension induced apoptosis http://purl.obolibrary.org/obo/GO_2000811 GO:2000812 biolink:BiologicalProcess regulation of barbed-end actin filament capping Any process that modulates the frequency, rate or extent of barbed-end actin filament capping. go.json regulation of barbed-end F-actin capping activity|regulation of barbed-end actin capping activity|regulation of plus-end F-actin capping activity|regulation of plus-end actin filament capping activity http://purl.obolibrary.org/obo/GO_2000812 GO:2000813 biolink:BiologicalProcess negative regulation of barbed-end actin filament capping Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping. go.json negative regulation of barbed-end F-actin capping activity|negative regulation of barbed-end actin capping activity|negative regulation of plus-end F-actin capping activity|negative regulation of plus-end actin filament capping activity http://purl.obolibrary.org/obo/GO_2000813 GO:2000814 biolink:BiologicalProcess positive regulation of barbed-end actin filament capping Any process that activates or increases the frequency, rate or extent of barbed-end actin filament capping. go.json positive regulation of barbed-end F-actin capping activity|positive regulation of barbed-end actin capping activity|positive regulation of plus-end F-actin capping activity|positive regulation of plus-end actin filament capping activity http://purl.obolibrary.org/obo/GO_2000814 GO:2000815 biolink:BiologicalProcess regulation of mRNA stability involved in response to oxidative stress A process of regulation of mRNA stability that is involved in a response to oxidative stress. go.json http://purl.obolibrary.org/obo/GO_2000815 GO:0075290 biolink:BiologicalProcess regulation of aplanospore formation Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. go.json http://purl.obolibrary.org/obo/GO_0075290 GO:0075291 biolink:BiologicalProcess positive regulation of aplanospore formation Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. go.json http://purl.obolibrary.org/obo/GO_0075291 GO:0075292 biolink:BiologicalProcess negative regulation of aplanospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. go.json http://purl.obolibrary.org/obo/GO_0075292 GO:0075293 biolink:BiologicalProcess response to host pH environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response of symbiont to host pH environment http://purl.obolibrary.org/obo/GO_0075293 GO:0075294 biolink:BiologicalProcess positive regulation by symbiont of entry into host Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. go.json activation by organism of entry into other organism during symbiotic interaction|activation by symbiont of entry into host|positive regulation by organism of entry into other organism during symbiotic interaction|positive regulation by organism of entry into other organism involved in symbiotic interaction|up regulation by organism of entry into other organism during symbiotic interaction|up regulation by symbiont of entry into host|up-regulation by organism of entry into other organism during symbiotic interaction|up-regulation by symbiont of entry into host|upregulation by organism of entry into other organism during symbiotic interaction|upregulation by symbiont of entry into host http://purl.obolibrary.org/obo/GO_0075294 GO:0075295 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075295 GO:0075296 biolink:BiologicalProcess positive regulation of ascospore formation Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus. go.json http://purl.obolibrary.org/obo/GO_0075296 GO:0075297 biolink:BiologicalProcess negative regulation of ascospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus. go.json http://purl.obolibrary.org/obo/GO_0075297 GO:0075298 biolink:BiologicalProcess regulation of zygospore formation Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase. go.json http://purl.obolibrary.org/obo/GO_0075298 GO:0075299 biolink:BiologicalProcess positive regulation of zygospore formation Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase. go.json http://purl.obolibrary.org/obo/GO_0075299 GO:0075203 biolink:BiologicalProcess positive regulation of penetration hypha formation Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont penetration hypha formation for entry into host http://purl.obolibrary.org/obo/GO_0075203 GO:0051236 biolink:BiologicalProcess establishment of RNA localization The directed movement of RNA to a specific location. go.json RNA positioning|RNA recruitment|establishment of RNA localisation http://purl.obolibrary.org/obo/GO_0051236 GO:0075204 biolink:BiologicalProcess obsolete negative regulation of symbiont penetration hypha formation for entry into host OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075204 GO:0051237 biolink:BiologicalProcess maintenance of RNA location Any process in which RNA is maintained in a location and prevented from moving elsewhere. go.json RNA retention|maintenance of RNA localization http://purl.obolibrary.org/obo/GO_0051237 GO:0051234 biolink:BiologicalProcess establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. go.json establishment of localisation http://purl.obolibrary.org/obo/GO_0051234 gocheck_do_not_annotate|goslim_agr|goslim_flybase_ribbon|goslim_mouse|goslim_pir GO:0075205 biolink:BiologicalProcess obsolete modulation by host of symbiont cAMP-mediated signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by host of symbiont cAMP-mediated signaling|modulation by host of symbiont cAMP-mediated signalling|regulation by host of symbiont cAMP-mediated signaling True http://purl.obolibrary.org/obo/GO_0075205 GO:0075206 biolink:BiologicalProcess obsolete positive regulation by host of symbiont cAMP-mediated signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by host of symbiont cAMP-mediated signaling True http://purl.obolibrary.org/obo/GO_0075206 GO:0051235 biolink:BiologicalProcess maintenance of location Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. go.json maintenance of localization|retention|sequestering|storage http://purl.obolibrary.org/obo/GO_0051235 GO:0075207 biolink:BiologicalProcess obsolete negative regulation by host of symbiont cAMP-mediated signal transduction OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by host of symbiont cAMP-mediated signaling True http://purl.obolibrary.org/obo/GO_0075207 GO:0075208 biolink:BiologicalProcess obsolete modulation by symbiont of host cAMP-mediated signal transduction OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host cAMP-mediated signaling True http://purl.obolibrary.org/obo/GO_0075208 GO:0075209 biolink:BiologicalProcess obsolete induction by symbiont of host cAMP-mediated signal transduction OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host cAMP-mediated signal transduction|positive regulation by symbiont of host cAMP-mediated signaling True http://purl.obolibrary.org/obo/GO_0075209 GO:0051238 biolink:BiologicalProcess sequestering of metal ion The process of binding or confining metal ions such that they are separated from other components of a biological system. go.json metal ion retention|metal ion sequestering|metal ion sequestration|metal ion storage|retention of metal ion|sequestration of metal ion|storage of metal ion http://purl.obolibrary.org/obo/GO_0051238 GO:0051239 biolink:BiologicalProcess regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. go.json http://purl.obolibrary.org/obo/GO_0051239 GO:2000863 biolink:BiologicalProcess positive regulation of estrogen secretion Any process that activates or increases the frequency, rate or extent of estrogen secretion. go.json positive regulation of oestrogen secretion http://purl.obolibrary.org/obo/GO_2000863 GO:0016907 biolink:MolecularActivity G protein-coupled acetylcholine receptor activity Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled acetylcholine receptor activity|G-protein coupled acetylcholine receptor activity|acetylcholine receptor activity, G-protein coupled|metabotropic acetylcholine receptor activity|muscarinic acetylcholine receptor activity http://purl.obolibrary.org/obo/GO_0016907 GO:2000864 biolink:BiologicalProcess regulation of estradiol secretion Any process that modulates the frequency, rate or extent of estradiol secretion. go.json regulation of oestradiol secretion http://purl.obolibrary.org/obo/GO_2000864 GO:0016908 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016908 GO:2000865 biolink:BiologicalProcess negative regulation of estradiol secretion Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion. go.json negative regulation of oestradiol secretion http://purl.obolibrary.org/obo/GO_2000865 GO:0016909 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016909 GO:2000866 biolink:BiologicalProcess positive regulation of estradiol secretion Any process that activates or increases the frequency, rate or extent of estradiol secretion. go.json positive regulation of oestradiol secretion http://purl.obolibrary.org/obo/GO_2000866 GO:0016903 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.2.-.- go.json oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors http://purl.obolibrary.org/obo/GO_0016903 GO:2000867 biolink:BiologicalProcess regulation of estrone secretion Any process that modulates the frequency, rate or extent of estrone secretion. go.json regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion|regulation of folliculin secretion http://purl.obolibrary.org/obo/GO_2000867 GO:2000868 biolink:BiologicalProcess negative regulation of estrone secretion Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion. go.json negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion|negative regulation of folliculin secretion http://purl.obolibrary.org/obo/GO_2000868 GO:0016904 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016904 GO:0016905 biolink:MolecularActivity myosin heavy chain kinase activity Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate. EC:2.7.11.7|RHEA:11424 go.json ATP:myosin heavy-chain O-phosphotransferase activity|ATP:myosin-heavy-chain O-phosphotransferase activity|MHCK|MIHC kinase activity|STK6|calmodulin-dependent myosin heavy chain kinase activity|myosin I heavy chain kinase activity|myosin I heavy-chain kinase activity|myosin II heavy chain kinase activity|myosin II heavy-chain kinase activity|myosin heavy chain kinase A activity|myosin heavy-chain kinase activity|myosin-heavy-chain kinase activity http://purl.obolibrary.org/obo/GO_0016905 GO:2000869 biolink:BiologicalProcess positive regulation of estrone secretion Any process that activates or increases the frequency, rate or extent of estrone secretion. go.json positive regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion|positive regulation of folliculin secretion http://purl.obolibrary.org/obo/GO_2000869 GO:0016906 biolink:MolecularActivity sterol 3-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol. EC:2.4.1.173|MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN|RHEA:22724 go.json UDP-glucose-sterol beta-glucosyltransferase activity|UDP-glucose-sterol glucosyltransferase activity|UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity|UDP-glucose:sterol glucosyltransferase activity|UDPG-SGTase activity|UDPG:sterol glucosyltransferase activity|UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity|sterol 3beta-glucosyltransferase activity|sterol glucosyltransferase activity|sterol-beta-D-glucosyltransferase activity|sterol:UDPG glucosyltransferase activity|uridine diphosphoglucose-poriferasterol glucosyltransferase activity|uridine diphosphoglucose-sterol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0016906 GO:1905410 biolink:BiologicalProcess regulation of mitotic cohesin unloading Any process that modulates the frequency, rate or extent of mitotic cohesin unloading. go.json http://purl.obolibrary.org/obo/GO_1905410 gocheck_do_not_annotate GO:1905400 biolink:BiologicalProcess negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process. go.json down regulation of activated CD4-positive, alpha-beta T cell apoptosis|down regulation of activated CD4-positive, alpha-beta T cell apoptotic process|down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|down regulation of activated CD4-positive, alpha-beta T-cell apoptosis|down regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|down-regulation of activated CD4-positive, alpha-beta T cell apoptosis|down-regulation of activated CD4-positive, alpha-beta T cell apoptotic process|down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|down-regulation of activated CD4-positive, alpha-beta T-cell apoptosis|down-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|downregulation of activated CD4-positive, alpha-beta T cell apoptosis|downregulation of activated CD4-positive, alpha-beta T cell apoptotic process|downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|downregulation of activated CD4-positive, alpha-beta T-cell apoptosis|downregulation of activated CD4-positive, alpha-beta T-cell apoptotic process|downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|inhibition of activated CD4-positive, alpha-beta T cell apoptosis|inhibition of activated CD4-positive, alpha-beta T cell apoptotic process|inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptosis|inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|inhibition of activated CD4-positive, alpha-beta T-cell apoptosis|inhibition of activated CD4-positive, alpha-beta T-cell apoptotic process|inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|negative regulation of activated CD4-positive, alpha-beta T cell apoptosis|negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|negative regulation of activated CD4-positive, alpha-beta T-cell apoptosis|negative regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905400 GO:1905401 biolink:BiologicalProcess positive regulation of activated CD4-positive, alpha-beta T cell apoptotic process Any process that activates or increases the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process. go.json activation of activated CD4-positive, alpha-beta T cell apoptosis|activation of activated CD4-positive, alpha-beta T cell apoptotic process|activation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|activation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|activation of activated CD4-positive, alpha-beta T-cell apoptosis|activation of activated CD4-positive, alpha-beta T-cell apoptotic process|activation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|activation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|positive regulation of activated CD4-positive, alpha-beta T cell apoptosis|positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|positive regulation of activated CD4-positive, alpha-beta T-cell apoptosis|positive regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|up regulation of activated CD4-positive, alpha-beta T cell apoptosis|up regulation of activated CD4-positive, alpha-beta T cell apoptotic process|up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|up regulation of activated CD4-positive, alpha-beta T-cell apoptosis|up regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|up-regulation of activated CD4-positive, alpha-beta T cell apoptosis|up-regulation of activated CD4-positive, alpha-beta T cell apoptotic process|up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|up-regulation of activated CD4-positive, alpha-beta T-cell apoptosis|up-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process|up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process|upregulation of activated CD4-positive, alpha-beta T cell apoptosis|upregulation of activated CD4-positive, alpha-beta T cell apoptotic process|upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis|upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process|upregulation of activated CD4-positive, alpha-beta T-cell apoptosis|upregulation of activated CD4-positive, alpha-beta T-cell apoptotic process|upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis|upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905401 GO:0016900 biolink:MolecularActivity oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule. EC:1.1.4.- go.json oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor http://purl.obolibrary.org/obo/GO_0016900 GO:0016901 biolink:MolecularActivity oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. EC:1.1.5.- go.json http://purl.obolibrary.org/obo/GO_0016901 GO:1905402 biolink:BiologicalProcess regulation of activated CD8-positive, alpha-beta T cell apoptotic process Any process that modulates the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. go.json regulation of activated CD8-positive, alpha-beta T cell apoptosis|regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|regulation of activated CD8-positive, alpha-beta T-cell apoptosis|regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905402 GO:1905403 biolink:BiologicalProcess negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. go.json down regulation of activated CD8-positive, alpha-beta T cell apoptosis|down regulation of activated CD8-positive, alpha-beta T cell apoptotic process|down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|down regulation of activated CD8-positive, alpha-beta T-cell apoptosis|down regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|down-regulation of activated CD8-positive, alpha-beta T cell apoptosis|down-regulation of activated CD8-positive, alpha-beta T cell apoptotic process|down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|down-regulation of activated CD8-positive, alpha-beta T-cell apoptosis|down-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|downregulation of activated CD8-positive, alpha-beta T cell apoptosis|downregulation of activated CD8-positive, alpha-beta T cell apoptotic process|downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|downregulation of activated CD8-positive, alpha-beta T-cell apoptosis|downregulation of activated CD8-positive, alpha-beta T-cell apoptotic process|downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|inhibition of activated CD8-positive, alpha-beta T cell apoptosis|inhibition of activated CD8-positive, alpha-beta T cell apoptotic process|inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptosis|inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|inhibition of activated CD8-positive, alpha-beta T-cell apoptosis|inhibition of activated CD8-positive, alpha-beta T-cell apoptotic process|inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|negative regulation of activated CD8-positive, alpha-beta T cell apoptosis|negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|negative regulation of activated CD8-positive, alpha-beta T-cell apoptosis|negative regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905403 GO:0016902 biolink:MolecularActivity obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound. go.json oxidoreductase activity, acting on the CH-OH group of donors, other acceptors True http://purl.obolibrary.org/obo/GO_0016902 GO:1905404 biolink:BiologicalProcess positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. go.json activation of activated CD8-positive, alpha-beta T cell apoptosis|activation of activated CD8-positive, alpha-beta T cell apoptotic process|activation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|activation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|activation of activated CD8-positive, alpha-beta T-cell apoptosis|activation of activated CD8-positive, alpha-beta T-cell apoptotic process|activation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|activation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|positive regulation of activated CD8-positive, alpha-beta T cell apoptosis|positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|positive regulation of activated CD8-positive, alpha-beta T-cell apoptosis|positive regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|up regulation of activated CD8-positive, alpha-beta T cell apoptosis|up regulation of activated CD8-positive, alpha-beta T cell apoptotic process|up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|up regulation of activated CD8-positive, alpha-beta T-cell apoptosis|up regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|up-regulation of activated CD8-positive, alpha-beta T cell apoptosis|up-regulation of activated CD8-positive, alpha-beta T cell apoptotic process|up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|up-regulation of activated CD8-positive, alpha-beta T-cell apoptosis|up-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process|up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process|upregulation of activated CD8-positive, alpha-beta T cell apoptosis|upregulation of activated CD8-positive, alpha-beta T cell apoptotic process|upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis|upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process|upregulation of activated CD8-positive, alpha-beta T-cell apoptosis|upregulation of activated CD8-positive, alpha-beta T-cell apoptotic process|upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis|upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1905404 GO:2000860 biolink:BiologicalProcess positive regulation of aldosterone secretion Any process that activates or increases the frequency, rate or extent of aldosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000860 GO:1905405 biolink:BiologicalProcess regulation of mitotic cohesin loading Any process that modulates the frequency, rate or extent of mitotic cohesin loading. go.json http://purl.obolibrary.org/obo/GO_1905405 GO:2000861 biolink:BiologicalProcess regulation of estrogen secretion Any process that modulates the frequency, rate or extent of estrogen secretion. go.json regulation of oestrogen secretion http://purl.obolibrary.org/obo/GO_2000861 GO:1905406 biolink:BiologicalProcess positive regulation of mitotic cohesin loading Any process that activates or increases the frequency, rate or extent of mitotic cohesin loading. go.json http://purl.obolibrary.org/obo/GO_1905406 GO:1905407 biolink:BiologicalProcess regulation of creatine transmembrane transporter activity Any process that modulates the frequency, rate or extent of creatine transmembrane transporter activity. go.json http://purl.obolibrary.org/obo/GO_1905407 gocheck_do_not_annotate GO:2000862 biolink:BiologicalProcess negative regulation of estrogen secretion Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion. go.json negative regulation of oestrogen secretion http://purl.obolibrary.org/obo/GO_2000862 GO:1905408 biolink:BiologicalProcess negative regulation of creatine transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity. go.json down regulation of creatine transmembrane transporter activity|down-regulation of creatine transmembrane transporter activity|downregulation of creatine transmembrane transporter activity|inhibition of creatine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1905408 gocheck_do_not_annotate GO:1905409 biolink:BiologicalProcess positive regulation of creatine transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of creatine transmembrane transporter activity. go.json activation of creatine transmembrane transporter activity|up regulation of creatine transmembrane transporter activity|up-regulation of creatine transmembrane transporter activity|upregulation of creatine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1905409 gocheck_do_not_annotate GO:0051232 biolink:BiologicalProcess meiotic spindle elongation The lengthening of the distance between poles of the spindle during a meiotic cell cycle. go.json spindle elongation during meiosis http://purl.obolibrary.org/obo/GO_0051232 GO:0051233 biolink:CellularComponent spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap. go.json central spindle|spindle equator http://purl.obolibrary.org/obo/GO_0051233 GO:0075200 biolink:BiologicalProcess obsolete negative regulation of symbiont haustorium neck formation for entry into host OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075200 GO:0075201 biolink:BiologicalProcess penetration hypha formation The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation of symbiont penetration hypha for entry into host|symbiont penetration hypha formation for entry into host http://purl.obolibrary.org/obo/GO_0075201 GO:0051230 biolink:BiologicalProcess spindle disassembly The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. go.json spindle breakdown|spindle catabolism|spindle degradation http://purl.obolibrary.org/obo/GO_0051230 GO:0051231 biolink:BiologicalProcess spindle elongation The cell cycle process in which the distance is lengthened between poles of the spindle. go.json http://purl.obolibrary.org/obo/GO_0051231 GO:0075202 biolink:BiologicalProcess regulation of penetration hypha formation Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation of symbiont penetration hypha formation for entry into host http://purl.obolibrary.org/obo/GO_0075202 GO:0051247 biolink:BiologicalProcess positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. go.json activation of cellular protein metabolic process|activation of protein metabolic process|positive regulation of cellular protein metabolic process|positive regulation of cellular protein metabolism|positive regulation of protein metabolism|stimulation of cellular protein metabolic process|stimulation of protein metabolic process|up regulation of cellular protein metabolic process|up regulation of protein metabolic process|up-regulation of cellular protein metabolic process|up-regulation of protein metabolic process|upregulation of cellular protein metabolic process|upregulation of protein metabolic process http://purl.obolibrary.org/obo/GO_0051247 GO:0051248 biolink:BiologicalProcess negative regulation of protein metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. go.json down regulation of cellular protein metabolic process|down regulation of protein metabolic process|down-regulation of cellular protein metabolic process|down-regulation of protein metabolic process|downregulation of cellular protein metabolic process|downregulation of protein metabolic process|inhibition of cellular protein metabolic process|inhibition of protein metabolic process|negative regulation of cellular protein metabolic process|negative regulation of cellular protein metabolism|negative regulation of protein metabolism http://purl.obolibrary.org/obo/GO_0051248 GO:0051245 biolink:BiologicalProcess negative regulation of cellular defense response Any process that stops, prevents, or reduces the rate of the cellular defense response. go.json down regulation of cellular defense response|down-regulation of cellular defense response|downregulation of cellular defense response|inhibition of cellular defense response|negative regulation of cellular defence response http://purl.obolibrary.org/obo/GO_0051245 GO:0051246 biolink:BiologicalProcess regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. go.json regulation of cellular protein metabolic process|regulation of cellular protein metabolism|regulation of protein metabolism http://purl.obolibrary.org/obo/GO_0051246 GO:0051249 biolink:BiologicalProcess regulation of lymphocyte activation Any process that modulates the frequency, rate or extent of lymphocyte activation. go.json http://purl.obolibrary.org/obo/GO_0051249 GO:0016918 biolink:MolecularActivity retinal binding Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. go.json UV-sensitive opsin|blue-sensitive opsin|green-sensitive opsin|long-wave-sensitive opsin|opsin|red-sensitive opsin|retinaldehyde binding|short-wave-sensitive opsin|violet-sensitive opsin|vitamin A binding http://purl.obolibrary.org/obo/GO_0016918 GO:2000874 biolink:BiologicalProcess regulation of glyoxylate cycle Any process that modulates the frequency, rate or extent of glyoxylate cycle. go.json regulation of glyoxylate bypass http://purl.obolibrary.org/obo/GO_2000874 GO:0016919 biolink:MolecularActivity obsolete nardilysin activity OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys. go.json N-arginine dibasic convertase activity|NRD convertase activity|NRD-convertase activity|nardilysin activity True http://purl.obolibrary.org/obo/GO_0016919 GO:2000875 biolink:BiologicalProcess negative regulation of glyoxylate cycle Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle. go.json negative regulation of glyoxylate bypass http://purl.obolibrary.org/obo/GO_2000875 GO:2000876 biolink:BiologicalProcess positive regulation of glyoxylate cycle Any process that activates or increases the frequency, rate or extent of glyoxylate cycle. go.json positive regulation of glyoxylate bypass http://purl.obolibrary.org/obo/GO_2000876 GO:2000877 biolink:BiologicalProcess negative regulation of oligopeptide transport Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport. go.json http://purl.obolibrary.org/obo/GO_2000877 GO:0016914 biolink:CellularComponent follicle-stimulating hormone complex A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity. go.json FSH complex|follicle stimulating hormone complex http://purl.obolibrary.org/obo/GO_0016914 GO:2000878 biolink:BiologicalProcess positive regulation of oligopeptide transport Any process that activates or increases the frequency, rate or extent of oligopeptide transport. go.json http://purl.obolibrary.org/obo/GO_2000878 GO:2000879 biolink:BiologicalProcess negative regulation of dipeptide transport Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport. go.json http://purl.obolibrary.org/obo/GO_2000879 GO:0016915 biolink:MolecularActivity obsolete activin OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. go.json activin True http://purl.obolibrary.org/obo/GO_0016915 GO:1905420 biolink:BiologicalProcess vascular associated smooth muscle cell differentiation involved in phenotypic switching Any vascular smooth muscle cell differentiation that is involved in phenotypic switching. go.json VSMC differentiation involved in phenotypic dimorphism|VSMC differentiation involved in phenotypic switching|vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism|vascular smooth muscle cell differentiation involved in phenotypic dimorphism|vascular smooth muscle cell differentiation involved in phenotypic switching http://purl.obolibrary.org/obo/GO_1905420 GO:0016916 biolink:MolecularActivity obsolete inhibin OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. go.json inhibin True http://purl.obolibrary.org/obo/GO_0016916 GO:0016917 biolink:MolecularActivity GABA receptor activity Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. go.json 4-aminobutanoate receptor activity|4-aminobutyrate receptor activity|GABA binding|gamma-aminobutyrate binding|gamma-aminobutyric acid binding|gamma-aminobutyric acid receptor activity http://purl.obolibrary.org/obo/GO_0016917 GO:1905421 biolink:BiologicalProcess regulation of plant organ morphogenesis Any process that modulates the frequency, rate or extent of plant organ morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1905421 GO:0016910 biolink:MolecularActivity obsolete SAP kinase 3 activity OBSOLETE. (Was not defined before being made obsolete). go.json SAP kinase 3 activity|SAPK3 True http://purl.obolibrary.org/obo/GO_0016910 GO:1905411 biolink:BiologicalProcess positive regulation of mitotic cohesin unloading Any process that activates or increases the frequency, rate or extent of mitotic cohesin unloading. go.json http://purl.obolibrary.org/obo/GO_1905411 gocheck_do_not_annotate GO:0016911 biolink:MolecularActivity obsolete SAP kinase 4 activity OBSOLETE. (Was not defined before being made obsolete). go.json SAP kinase 4 activity|SAPK4 True http://purl.obolibrary.org/obo/GO_0016911 GO:1905412 biolink:BiologicalProcess negative regulation of mitotic cohesin loading Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin loading. go.json http://purl.obolibrary.org/obo/GO_1905412 GO:0016912 biolink:MolecularActivity obsolete SAP kinase 5 activity OBSOLETE. (Was not defined before being made obsolete). go.json SAP kinase 5 activity|SAPK5 True http://purl.obolibrary.org/obo/GO_0016912 GO:1905413 biolink:BiologicalProcess regulation of dense core granule exocytosis Any process that modulates the frequency, rate or extent of dense core granule exocytosis. go.json regulation of dense core vesicle exocytosis http://purl.obolibrary.org/obo/GO_1905413 GO:1905414 biolink:BiologicalProcess negative regulation of dense core granule exocytosis Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule exocytosis. go.json down regulation of dense core granule exocytosis|down regulation of dense core vesicle exocytosis|down-regulation of dense core granule exocytosis|down-regulation of dense core vesicle exocytosis|downregulation of dense core granule exocytosis|downregulation of dense core vesicle exocytosis|inhibition of dense core granule exocytosis|inhibition of dense core vesicle exocytosis|negative regulation of dense core vesicle exocytosis http://purl.obolibrary.org/obo/GO_1905414 GO:0016913 biolink:MolecularActivity follicle-stimulating hormone activity The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. go.json FSH activity|follicle stimulating hormone activity|follitropin activity http://purl.obolibrary.org/obo/GO_0016913 GO:2000870 biolink:BiologicalProcess regulation of progesterone secretion Any process that modulates the frequency, rate or extent of progesterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000870 GO:1905415 biolink:BiologicalProcess positive regulation of dense core granule exocytosis Any process that activates or increases the frequency, rate or extent of dense core granule exocytosis. go.json activation of dense core granule exocytosis|activation of dense core vesicle exocytosis|positive regulation of dense core vesicle exocytosis|up regulation of dense core granule exocytosis|up regulation of dense core vesicle exocytosis|up-regulation of dense core granule exocytosis|up-regulation of dense core vesicle exocytosis|upregulation of dense core granule exocytosis|upregulation of dense core vesicle exocytosis http://purl.obolibrary.org/obo/GO_1905415 GO:1905416 biolink:BiologicalProcess regulation of amoeboid sperm motility Any process that modulates the frequency, rate or extent of amoeboid sperm motility. go.json regulation of ameboid sperm motility|regulation of ameboid sperm movement|regulation of amoeboid sperm movement http://purl.obolibrary.org/obo/GO_1905416 GO:2000871 biolink:BiologicalProcess negative regulation of progesterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000871 GO:1905417 biolink:BiologicalProcess negative regulation of amoeboid sperm motility Any process that stops, prevents or reduces the frequency, rate or extent of amoeboid sperm motility. go.json down regulation of ameboid sperm motility|down regulation of ameboid sperm movement|down regulation of amoeboid sperm motility|down regulation of amoeboid sperm movement|down-regulation of ameboid sperm motility|down-regulation of ameboid sperm movement|down-regulation of amoeboid sperm motility|down-regulation of amoeboid sperm movement|downregulation of ameboid sperm motility|downregulation of ameboid sperm movement|downregulation of amoeboid sperm motility|downregulation of amoeboid sperm movement|inhibition of ameboid sperm motility|inhibition of ameboid sperm movement|inhibition of amoeboid sperm motility|inhibition of amoeboid sperm movement|negative regulation of ameboid sperm motility|negative regulation of ameboid sperm movement|negative regulation of amoeboid sperm movement http://purl.obolibrary.org/obo/GO_1905417 GO:2000872 biolink:BiologicalProcess positive regulation of progesterone secretion Any process that activates or increases the frequency, rate or extent of progesterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000872 GO:1905418 biolink:BiologicalProcess positive regulation of amoeboid sperm motility Any process that activates or increases the frequency, rate or extent of amoeboid sperm motility. go.json activation of ameboid sperm motility|activation of ameboid sperm movement|activation of amoeboid sperm motility|activation of amoeboid sperm movement|positive regulation of ameboid sperm motility|positive regulation of ameboid sperm movement|positive regulation of amoeboid sperm movement|up regulation of ameboid sperm motility|up regulation of ameboid sperm movement|up regulation of amoeboid sperm motility|up regulation of amoeboid sperm movement|up-regulation of ameboid sperm motility|up-regulation of ameboid sperm movement|up-regulation of amoeboid sperm motility|up-regulation of amoeboid sperm movement|upregulation of ameboid sperm motility|upregulation of ameboid sperm movement|upregulation of amoeboid sperm motility|upregulation of amoeboid sperm movement http://purl.obolibrary.org/obo/GO_1905418 GO:2000873 biolink:BiologicalProcess obsolete regulation of histone H4 acetylation involved in response to DNA damage stimulus OBSOLETE. Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus. go.json regulation of histone H4 acetylation involved in DNA damage response|regulation of histone H4 acetylation involved in cellular DNA damage response|regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus|regulation of histone H4 acetylation involved in response to DNA damage|regulation of histone H4 acetylation involved in response to genotoxic stress True http://purl.obolibrary.org/obo/GO_2000873 GO:1905419 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905419 GO:0051240 biolink:BiologicalProcess positive regulation of multicellular organismal process Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. go.json activation of multicellular organismal process|stimulation of multicellular organismal process|up regulation of multicellular organismal process|up-regulation of multicellular organismal process|upregulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_0051240 GO:0051243 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051243 GO:0051244 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051244 GO:0051241 biolink:BiologicalProcess negative regulation of multicellular organismal process Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. go.json down regulation of multicellular organismal process|down-regulation of multicellular organismal process|downregulation of multicellular organismal process|inhibition of multicellular organismal process http://purl.obolibrary.org/obo/GO_0051241 GO:0051242 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051242 GO:0051258 biolink:BiologicalProcess protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. go.json protein polymer biosynthesis|protein polymer biosynthetic process|protein polymer formation http://purl.obolibrary.org/obo/GO_0051258 goslim_pir GO:0075225 biolink:BiologicalProcess negative regulation of sporangium germination Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination. go.json negative regulation of sporangium germination on or near host http://purl.obolibrary.org/obo/GO_0075225 GO:0051259 biolink:BiologicalProcess protein complex oligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. go.json protein multimerization|protein oligomer assembly|protein oligomer biosynthesis|protein oligomer biosynthetic process|protein oligomer formation|protein oligomerization http://purl.obolibrary.org/obo/GO_0051259 GO:0075226 biolink:BiologicalProcess encysted zoospore germination The physiological, developmental and morphological changes that occur in an encysted zoospore, that germinates by developing a germ tube that may penetrate the host directly or indirectly through an appressorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json encysted zoospore germination on or near host http://purl.obolibrary.org/obo/GO_0075226 GO:0051256 biolink:BiologicalProcess mitotic spindle midzone assembly The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. go.json mitotic spindle midzone biogenesis|mitotic spindle midzone biosynthesis|mitotic spindle midzone formation|spindle midzone assembly involved in mitosis|spindle midzone biogenesis involved in mitosis|spindle midzone formation involved in mitosis http://purl.obolibrary.org/obo/GO_0051256 GO:0075227 biolink:BiologicalProcess regulation of encysted zoospore germination Any process that modulates the frequency, rate or extent of an encysted zoospore germination. go.json modulation of encysted zoospore germination on or near host|regulation of encysted zoospore germination on or near host http://purl.obolibrary.org/obo/GO_0075227 GO:0075228 biolink:BiologicalProcess positive regulation of encysted zoospore germination Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination. go.json positive regulation of encysted zoospore germination on or near host http://purl.obolibrary.org/obo/GO_0075228 GO:0051257 biolink:BiologicalProcess meiotic spindle midzone assembly The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis. go.json meiotic spindle midzone biogenesis|meiotic spindle midzone biosynthesis|meiotic spindle midzone formation|spindle midzone assembly involved in meiosis|spindle midzone biogenesis involved in meiosis|spindle midzone biosynthesis involved in meiosis|spindle midzone formation involved in meiosis http://purl.obolibrary.org/obo/GO_0051257 GO:0075229 biolink:BiologicalProcess negative regulation of encysted zoospore germination Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination. go.json negative regulation of encysted zoospore germination on or near host http://purl.obolibrary.org/obo/GO_0075229 GO:2000885 biolink:BiologicalProcess galactoglucomannan catabolic process The chemical reactions and pathways resulting in the breakdown of a galactoglucomannan. go.json galactoglucomannan catabolism http://purl.obolibrary.org/obo/GO_2000885 GO:2000886 biolink:BiologicalProcess glucuronoxylan catabolic process The chemical reactions and pathways resulting in the breakdown of a glucuronoxylan. go.json glucuronoxylan catabolism http://purl.obolibrary.org/obo/GO_2000886 GO:2000887 biolink:BiologicalProcess glucuronoarabinoxylan catabolic process The chemical reactions and pathways resulting in the breakdown of a glucuronoarabinoxylan. go.json glucuronoarabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000887 GO:2000888 biolink:BiologicalProcess arabinoxylan-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of an arabinoxylan. go.json arabinoxylan catabolic process|arabinoxylan catabolism http://purl.obolibrary.org/obo/GO_2000888 GO:2000889 biolink:BiologicalProcess cellodextrin metabolic process The chemical reactions and pathways involving a cellodextrin. go.json cellodextrin metabolism http://purl.obolibrary.org/obo/GO_2000889 GO:1905430 biolink:BiologicalProcess cellular response to glycine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus. go.json cellular response to Gly|cellular response to aminoacetic acid|cellular response to aminoethanoic acid|cellular response to glycin http://purl.obolibrary.org/obo/GO_1905430 GO:1905431 biolink:BiologicalProcess microcystin transport The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1905431 GO:1905432 biolink:BiologicalProcess regulation of retrograde trans-synaptic signaling by neuropeptide Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. go.json regulation of neuropeptide-mediated retrograde trans-synaptic signaling http://purl.obolibrary.org/obo/GO_1905432 GO:1905422 biolink:BiologicalProcess negative regulation of plant organ morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of plant organ morphogenesis. go.json down regulation of plant organ morphogenesis|down-regulation of plant organ morphogenesis|downregulation of plant organ morphogenesis|inhibition of plant organ morphogenesis http://purl.obolibrary.org/obo/GO_1905422 GO:1905423 biolink:BiologicalProcess positive regulation of plant organ morphogenesis Any process that activates or increases the frequency, rate or extent of plant organ morphogenesis. go.json activation of plant organ morphogenesis|up regulation of plant organ morphogenesis|up-regulation of plant organ morphogenesis|upregulation of plant organ morphogenesis http://purl.obolibrary.org/obo/GO_1905423 GO:1905424 biolink:BiologicalProcess regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. go.json regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wg signaling pathway involved in mDA neuron differentiation|regulation of Wg signaling pathway involved in midbrain DA neurogenesis|regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wg signalling pathway involved in mDA neuron differentiation|regulation of Wg signalling pathway involved in midbrain DA neurogenesis|regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wingless signaling pathway involved in mDA neuron differentiation|regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wingless signalling pathway involved in mDA neuron differentiation|regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt signaling pathway involved in mDA neuron differentiation|regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt-mediated midbrain DA neuron differentiation|regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of frizzled signaling pathway involved in mDA neuron differentiation|regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of frizzled signalling pathway involved in mDA neuron differentiation|regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|regulation of midbrain dopaminergic neuron differentiation by regulation of Wnt signaling http://purl.obolibrary.org/obo/GO_1905424 GO:1905425 biolink:BiologicalProcess negative regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. go.json down regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wg signaling pathway involved in mDA neuron differentiation|down regulation of Wg signaling pathway involved in midbrain DA neurogenesis|down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|down regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wg signalling pathway involved in mDA neuron differentiation|down regulation of Wg signalling pathway involved in midbrain DA neurogenesis|down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|down regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wingless signaling pathway involved in mDA neuron differentiation|down regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|down regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wingless signalling pathway involved in mDA neuron differentiation|down regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|down regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|down regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|down regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|down regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|down regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wnt signaling pathway involved in mDA neuron differentiation|down regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|down regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|down regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|down regulation of Wnt-mediated midbrain DA neuron differentiation|down regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of frizzled signaling pathway involved in mDA neuron differentiation|down regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|down regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|down regulation of frizzled signalling pathway involved in mDA neuron differentiation|down regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wg signaling pathway involved in mDA neuron differentiation|down-regulation of Wg signaling pathway involved in midbrain DA neurogenesis|down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wg signalling pathway involved in mDA neuron differentiation|down-regulation of Wg signalling pathway involved in midbrain DA neurogenesis|down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wingless signaling pathway involved in mDA neuron differentiation|down-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wingless signalling pathway involved in mDA neuron differentiation|down-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|down-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|down-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wnt signaling pathway involved in mDA neuron differentiation|down-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|down-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|down-regulation of Wnt-mediated midbrain DA neuron differentiation|down-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of frizzled signaling pathway involved in mDA neuron differentiation|down-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|down-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|down-regulation of frizzled signalling pathway involved in mDA neuron differentiation|down-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|downregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wg signaling pathway involved in mDA neuron differentiation|downregulation of Wg signaling pathway involved in midbrain DA neurogenesis|downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|downregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wg signalling pathway involved in mDA neuron differentiation|downregulation of Wg signalling pathway involved in midbrain DA neurogenesis|downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|downregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wingless signaling pathway involved in mDA neuron differentiation|downregulation of Wingless signaling pathway involved in midbrain DA neurogenesis|downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|downregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wingless signalling pathway involved in mDA neuron differentiation|downregulation of Wingless signalling pathway involved in midbrain DA neurogenesis|downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|downregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|downregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|downregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|downregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|downregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wnt signaling pathway involved in mDA neuron differentiation|downregulation of Wnt signaling pathway involved in midbrain DA neurogenesis|downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|downregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|downregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|downregulation of Wnt-mediated midbrain DA neuron differentiation|downregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of frizzled signaling pathway involved in mDA neuron differentiation|downregulation of frizzled signaling pathway involved in midbrain DA neurogenesis|downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|downregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|downregulation of frizzled signalling pathway involved in mDA neuron differentiation|downregulation of frizzled signalling pathway involved in midbrain DA neurogenesis|downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|inhibition of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wg signaling pathway involved in mDA neuron differentiation|inhibition of Wg signaling pathway involved in midbrain DA neurogenesis|inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron production|inhibition of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wg signalling pathway involved in mDA neuron differentiation|inhibition of Wg signalling pathway involved in midbrain DA neurogenesis|inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron production|inhibition of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wingless signaling pathway involved in mDA neuron differentiation|inhibition of Wingless signaling pathway involved in midbrain DA neurogenesis|inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron production|inhibition of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wingless signalling pathway involved in mDA neuron differentiation|inhibition of Wingless signalling pathway involved in midbrain DA neurogenesis|inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron production|inhibition of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wnt receptor signaling pathway involved in mDA neuron differentiation|inhibition of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|inhibition of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wnt receptor signalling pathway involved in mDA neuron differentiation|inhibition of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|inhibition of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wnt signaling pathway involved in mDA neuron differentiation|inhibition of Wnt signaling pathway involved in midbrain DA neurogenesis|inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron production|inhibition of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of Wnt-activated signaling pathway involved in mDA neuron differentiation|inhibition of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|inhibition of Wnt-mediated midbrain DA neuron differentiation|inhibition of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of frizzled signaling pathway involved in mDA neuron differentiation|inhibition of frizzled signaling pathway involved in midbrain DA neurogenesis|inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron production|inhibition of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|inhibition of frizzled signalling pathway involved in mDA neuron differentiation|inhibition of frizzled signalling pathway involved in midbrain DA neurogenesis|inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wg signaling pathway involved in mDA neuron differentiation|negative regulation of Wg signaling pathway involved in midbrain DA neurogenesis|negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wg signalling pathway involved in mDA neuron differentiation|negative regulation of Wg signalling pathway involved in midbrain DA neurogenesis|negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wingless signaling pathway involved in mDA neuron differentiation|negative regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wingless signalling pathway involved in mDA neuron differentiation|negative regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|negative regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|negative regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wnt signaling pathway involved in mDA neuron differentiation|negative regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|negative regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|negative regulation of Wnt-mediated midbrain DA neuron differentiation|negative regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of frizzled signaling pathway involved in mDA neuron differentiation|negative regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|negative regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|negative regulation of frizzled signalling pathway involved in mDA neuron differentiation|negative regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|negative regulation of midbrain dopaminergic neuron differentiation by negative regulation of Wnt signaling http://purl.obolibrary.org/obo/GO_1905425 GO:2000880 biolink:BiologicalProcess positive regulation of dipeptide transport Any process that activates or increases the frequency, rate or extent of dipeptide transport. go.json http://purl.obolibrary.org/obo/GO_2000880 GO:1905426 biolink:BiologicalProcess positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. go.json activation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wg signaling pathway involved in mDA neuron differentiation|activation of Wg signaling pathway involved in midbrain DA neurogenesis|activation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wg signaling pathway involved in midbrain dopaminergic neuron production|activation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wg signalling pathway involved in mDA neuron differentiation|activation of Wg signalling pathway involved in midbrain DA neurogenesis|activation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wg signalling pathway involved in midbrain dopaminergic neuron production|activation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wingless signaling pathway involved in mDA neuron differentiation|activation of Wingless signaling pathway involved in midbrain DA neurogenesis|activation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|activation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wingless signalling pathway involved in mDA neuron differentiation|activation of Wingless signalling pathway involved in midbrain DA neurogenesis|activation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|activation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt receptor signaling pathway involved in mDA neuron differentiation|activation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|activation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt receptor signalling pathway involved in mDA neuron differentiation|activation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|activation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt signaling pathway involved in mDA neuron differentiation|activation of Wnt signaling pathway involved in midbrain DA neurogenesis|activation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|activation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt-activated signaling pathway involved in mDA neuron differentiation|activation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|activation of Wnt-mediated midbrain DA neuron differentiation|activation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of frizzled signaling pathway involved in mDA neuron differentiation|activation of frizzled signaling pathway involved in midbrain DA neurogenesis|activation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|activation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of frizzled signalling pathway involved in mDA neuron differentiation|activation of frizzled signalling pathway involved in midbrain DA neurogenesis|activation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wg signaling pathway involved in mDA neuron differentiation|positive regulation of Wg signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wg signalling pathway involved in mDA neuron differentiation|positive regulation of Wg signalling pathway involved in midbrain DA neurogenesis|positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wingless signaling pathway involved in mDA neuron differentiation|positive regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wingless signalling pathway involved in mDA neuron differentiation|positive regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|positive regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|positive regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt signaling pathway involved in mDA neuron differentiation|positive regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|positive regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt-mediated midbrain DA neuron differentiation|positive regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of frizzled signaling pathway involved in mDA neuron differentiation|positive regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of frizzled signalling pathway involved in mDA neuron differentiation|positive regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of midbrain dopaminergic neuron differentiation by positive regulation of Wnt signaling|up regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wg signaling pathway involved in mDA neuron differentiation|up regulation of Wg signaling pathway involved in midbrain DA neurogenesis|up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wg signalling pathway involved in mDA neuron differentiation|up regulation of Wg signalling pathway involved in midbrain DA neurogenesis|up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wingless signaling pathway involved in mDA neuron differentiation|up regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wingless signalling pathway involved in mDA neuron differentiation|up regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|up regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt signaling pathway involved in mDA neuron differentiation|up regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|up regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt-mediated midbrain DA neuron differentiation|up regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of frizzled signaling pathway involved in mDA neuron differentiation|up regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|up regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of frizzled signalling pathway involved in mDA neuron differentiation|up regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wg signaling pathway involved in mDA neuron differentiation|up-regulation of Wg signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wg signalling pathway involved in mDA neuron differentiation|up-regulation of Wg signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wingless signaling pathway involved in mDA neuron differentiation|up-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wingless signalling pathway involved in mDA neuron differentiation|up-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|up-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt signaling pathway involved in mDA neuron differentiation|up-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|up-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wnt-mediated midbrain DA neuron differentiation|up-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of frizzled signaling pathway involved in mDA neuron differentiation|up-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of frizzled signalling pathway involved in mDA neuron differentiation|up-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wg signaling pathway involved in mDA neuron differentiation|upregulation of Wg signaling pathway involved in midbrain DA neurogenesis|upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wg signalling pathway involved in mDA neuron differentiation|upregulation of Wg signalling pathway involved in midbrain DA neurogenesis|upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wingless signaling pathway involved in mDA neuron differentiation|upregulation of Wingless signaling pathway involved in midbrain DA neurogenesis|upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wingless signalling pathway involved in mDA neuron differentiation|upregulation of Wingless signalling pathway involved in midbrain DA neurogenesis|upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|upregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|upregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt signaling pathway involved in mDA neuron differentiation|upregulation of Wnt signaling pathway involved in midbrain DA neurogenesis|upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|upregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt-mediated midbrain DA neuron differentiation|upregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of frizzled signaling pathway involved in mDA neuron differentiation|upregulation of frizzled signaling pathway involved in midbrain DA neurogenesis|upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|upregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of frizzled signalling pathway involved in mDA neuron differentiation|upregulation of frizzled signalling pathway involved in midbrain DA neurogenesis|upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1905426 GO:2000881 biolink:BiologicalProcess regulation of starch catabolic process Any process that modulates the frequency, rate or extent of starch catabolic process. go.json regulation of starch breakdown|regulation of starch catabolism|regulation of starch degradation http://purl.obolibrary.org/obo/GO_2000881 GO:1905427 biolink:BiologicalProcess intracellular signal transduction involved in positive regulation of cell growth Any intracellular signal transduction that is involved in positive regulation of cell growth. go.json intracellular protein kinase cascade involved in activation of cell growth|intracellular protein kinase cascade involved in positive regulation of cell growth|intracellular protein kinase cascade involved in stimulation of cell growth|intracellular protein kinase cascade involved in up regulation of cell growth|intracellular protein kinase cascade involved in up-regulation of cell growth|intracellular protein kinase cascade involved in upregulation of cell growth|intracellular signal transduction involved in activation of cell growth|intracellular signal transduction involved in stimulation of cell growth|intracellular signal transduction involved in up regulation of cell growth|intracellular signal transduction involved in up-regulation of cell growth|intracellular signal transduction involved in upregulation of cell growth|intracellular signal transduction pathway involved in activation of cell growth|intracellular signal transduction pathway involved in positive regulation of cell growth|intracellular signal transduction pathway involved in stimulation of cell growth|intracellular signal transduction pathway involved in up regulation of cell growth|intracellular signal transduction pathway involved in up-regulation of cell growth|intracellular signal transduction pathway involved in upregulation of cell growth|intracellular signaling cascade involved in activation of cell growth|intracellular signaling cascade involved in positive regulation of cell growth|intracellular signaling cascade involved in stimulation of cell growth|intracellular signaling cascade involved in up regulation of cell growth|intracellular signaling cascade involved in up-regulation of cell growth|intracellular signaling cascade involved in upregulation of cell growth|intracellular signaling chain involved in activation of cell growth|intracellular signaling chain involved in positive regulation of cell growth|intracellular signaling chain involved in stimulation of cell growth|intracellular signaling chain involved in up regulation of cell growth|intracellular signaling chain involved in up-regulation of cell growth|intracellular signaling chain involved in upregulation of cell growth|intracellular signaling pathway involved in activation of cell growth|intracellular signaling pathway involved in positive regulation of cell growth|intracellular signaling pathway involved in stimulation of cell growth|intracellular signaling pathway involved in up regulation of cell growth|intracellular signaling pathway involved in up-regulation of cell growth|intracellular signaling pathway involved in upregulation of cell growth|protein kinase cascade involved in activation of cell growth|protein kinase cascade involved in positive regulation of cell growth|protein kinase cascade involved in stimulation of cell growth|protein kinase cascade involved in up regulation of cell growth|protein kinase cascade involved in up-regulation of cell growth|protein kinase cascade involved in upregulation of cell growth|signal transduction via intracellular signaling cascade involved in activation of cell growth|signal transduction via intracellular signaling cascade involved in positive regulation of cell growth|signal transduction via intracellular signaling cascade involved in stimulation of cell growth|signal transduction via intracellular signaling cascade involved in up regulation of cell growth|signal transduction via intracellular signaling cascade involved in up-regulation of cell growth|signal transduction via intracellular signaling cascade involved in upregulation of cell growth|signal transmission via intracellular cascade involved in activation of cell growth|signal transmission via intracellular cascade involved in positive regulation of cell growth|signal transmission via intracellular cascade involved in stimulation of cell growth|signal transmission via intracellular cascade involved in up regulation of cell growth|signal transmission via intracellular cascade involved in up-regulation of cell growth|signal transmission via intracellular cascade involved in upregulation of cell growth http://purl.obolibrary.org/obo/GO_1905427 GO:2000882 biolink:BiologicalProcess negative regulation of starch catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process. go.json negative regulation of starch breakdown|negative regulation of starch catabolism|negative regulation of starch degradation http://purl.obolibrary.org/obo/GO_2000882 GO:2000883 biolink:BiologicalProcess positive regulation of starch catabolic process Any process that activates or increases the frequency, rate or extent of starch catabolic process. go.json positive regulation of starch breakdown|positive regulation of starch catabolism|positive regulation of starch degradation http://purl.obolibrary.org/obo/GO_2000883 GO:1905428 biolink:BiologicalProcess regulation of plant organ formation Any process that modulates the frequency, rate or extent of plant organ formation. go.json http://purl.obolibrary.org/obo/GO_1905428 GO:1905429 biolink:BiologicalProcess response to glycine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus. go.json response to Gly|response to aminoacetic acid|response to aminoethanoic acid|response to glycin http://purl.obolibrary.org/obo/GO_1905429 GO:2000884 biolink:BiologicalProcess glucomannan catabolic process The chemical reactions and pathways resulting in the breakdown of a glucomannan. go.json glucomannan catabolism http://purl.obolibrary.org/obo/GO_2000884 GO:0051250 biolink:BiologicalProcess negative regulation of lymphocyte activation Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. go.json down regulation of lymphocyte activation|down-regulation of lymphocyte activation|downregulation of lymphocyte activation|inhibition of lymphocyte activation http://purl.obolibrary.org/obo/GO_0051250 GO:0051251 biolink:BiologicalProcess positive regulation of lymphocyte activation Any process that activates or increases the frequency, rate or extent of lymphocyte activation. go.json activation of lymphocyte activation|stimulation of lymphocyte activation|up regulation of lymphocyte activation|up-regulation of lymphocyte activation|upregulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_0051251 GO:0075220 biolink:BiologicalProcess positive regulation of zoospore encystment on host Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075220 GO:0051254 biolink:BiologicalProcess positive regulation of RNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. go.json activation of RNA metabolic process|positive regulation of RNA metabolism|stimulation of RNA metabolic process|up regulation of RNA metabolic process|up-regulation of RNA metabolic process|upregulation of RNA metabolic process http://purl.obolibrary.org/obo/GO_0051254 GO:0075221 biolink:BiologicalProcess negative regulation of zoospore encystment on host Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075221 GO:0051255 biolink:BiologicalProcess spindle midzone assembly The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. go.json spindle midzone biogenesis|spindle midzone biosynthesis|spindle midzone formation http://purl.obolibrary.org/obo/GO_0051255 GO:0075222 biolink:BiologicalProcess sporangium germination The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth. A sporangium is a structure producing and containing spores. go.json direct germination on or near host|germination of symbiont sporangium on or near host|sporangium germination on or near host|symbiont sporangium germination on or near host http://purl.obolibrary.org/obo/GO_0075222 GO:0051252 biolink:BiologicalProcess regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. go.json regulation of RNA metabolism http://purl.obolibrary.org/obo/GO_0051252 GO:0075223 biolink:BiologicalProcess regulation of sporangium germination Any process that modulates the frequency, rate or extent of sporangium germination. go.json modulation of sporangium germination|modulation of sporangium germination on or near host http://purl.obolibrary.org/obo/GO_0075223 GO:0051253 biolink:BiologicalProcess negative regulation of RNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. go.json down regulation of RNA metabolic process|down-regulation of RNA metabolic process|downregulation of RNA metabolic process|inhibition of RNA metabolic process|negative regulation of RNA metabolism http://purl.obolibrary.org/obo/GO_0051253 GO:0075224 biolink:BiologicalProcess positive regulation of sporangium germination Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination. go.json positive regulation of sporangium germination on or near host http://purl.obolibrary.org/obo/GO_0075224 GO:0075214 biolink:BiologicalProcess spore encystment The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json spore encystment on host http://purl.obolibrary.org/obo/GO_0075214 GO:0051269 biolink:MolecularActivity alpha-keto ester reductase activity Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic. EC:1.2.-.- go.json http://purl.obolibrary.org/obo/GO_0051269 GO:0075215 biolink:BiologicalProcess modulation of spore encystment on host Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075215 GO:0051267 biolink:MolecularActivity CP2 mannose-ethanolamine phosphotransferase activity Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. go.json CP2 EtN-P transferase activity|CP2 ethanolamine phosphate transferase activity|CP2 phosphoethanolamine transferase activity|addition of ethanolamine phosphate to mannose of GPI precursor CP2|gpi7 activity http://purl.obolibrary.org/obo/GO_0051267 GO:0075216 biolink:BiologicalProcess positive regulation of spore encystment on host Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075216 GO:0075217 biolink:BiologicalProcess negative regulation of spore encystment on host Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075217 GO:0051268 biolink:MolecularActivity alpha-keto amide reductase activity Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic. go.json http://purl.obolibrary.org/obo/GO_0051268 GO:0075218 biolink:BiologicalProcess zoospore encystment on host The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075218 GO:0075219 biolink:BiologicalProcess modulation of zoospore encystment on host Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075219 GO:2000896 biolink:BiologicalProcess amylopectin metabolic process The chemical reactions and pathways involving an amylopectin. go.json Amylopectin metabolism http://purl.obolibrary.org/obo/GO_2000896 GO:2000897 biolink:BiologicalProcess amylopectin catabolic process The chemical reactions and pathways resulting in the breakdown of an amylopectin. go.json Amylopectin catabolism http://purl.obolibrary.org/obo/GO_2000897 GO:2000898 biolink:BiologicalProcess regulation of glucomannan catabolic process Any process that modulates the frequency, rate or extent of glucomannan catabolic process. go.json regulation of glucomannan catabolism http://purl.obolibrary.org/obo/GO_2000898 GO:2000899 biolink:BiologicalProcess xyloglucan catabolic process The chemical reactions and pathways resulting in the breakdown of a xyloglucan. go.json xyloglucan catabolism http://purl.obolibrary.org/obo/GO_2000899 GO:1905440 biolink:BiologicalProcess cellular response to chondroitin 6'-sulfate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus. go.json http://purl.obolibrary.org/obo/GO_1905440 GO:1905441 biolink:BiologicalProcess response to chondroitin 4'-sulfate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus. go.json http://purl.obolibrary.org/obo/GO_1905441 GO:1905442 biolink:BiologicalProcess cellular response to chondroitin 4'-sulfate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus. go.json http://purl.obolibrary.org/obo/GO_1905442 GO:1905443 biolink:BiologicalProcess regulation of clathrin coat assembly Any process that modulates the frequency, rate or extent of clathrin coat assembly. go.json regulation of clathrin cage assembly http://purl.obolibrary.org/obo/GO_1905443 GO:1905433 biolink:BiologicalProcess negative regulation of retrograde trans-synaptic signaling by neuropeptide Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. go.json down regulation of retrograde trans-synaptic signaling by neuropeptide|down-regulation of retrograde trans-synaptic signaling by neuropeptide|downregulation of retrograde trans-synaptic signaling by neuropeptide|inhibition of neuropeptide-mediated retrograde trans-synaptic signaling|inhibition of retrograde trans-synaptic signaling by neuropeptide|negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling http://purl.obolibrary.org/obo/GO_1905433 GO:1905434 biolink:BiologicalProcess positive regulation of retrograde trans-synaptic signaling by neuropeptide Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. go.json activation of retrograde trans-synaptic signaling by neuropeptide|positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling|up regulation of retrograde trans-synaptic signaling by neuropeptide|up-regulation of retrograde trans-synaptic signaling by neuropeptide|upregulation of retrograde trans-synaptic signaling by neuropeptide http://purl.obolibrary.org/obo/GO_1905434 GO:1905435 biolink:BiologicalProcess obsolete regulation of histone H3-K4 trimethylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K4 trimethylation. go.json True http://purl.obolibrary.org/obo/GO_1905435 GO:2000890 biolink:BiologicalProcess cellodextrin catabolic process The chemical reactions and pathways resulting in the breakdown of a cellodextrin. go.json cellodextrin catabolism http://purl.obolibrary.org/obo/GO_2000890 GO:2000891 biolink:BiologicalProcess cellobiose metabolic process The chemical reactions and pathways involving a cellobiose. go.json cellobiose metabolism http://purl.obolibrary.org/obo/GO_2000891 GO:1905436 biolink:BiologicalProcess obsolete negative regulation of histone H3-K4 trimethylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 trimethylation. go.json down regulation of histone H3-K4 trimethylation|down-regulation of histone H3-K4 trimethylation|downregulation of histone H3-K4 trimethylation|inhibition of histone H3-K4 trimethylation True http://purl.obolibrary.org/obo/GO_1905436 GO:1905437 biolink:BiologicalProcess obsolete positive regulation of histone H3-K4 trimethylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K4 trimethylation. go.json activation of histone H3-K4 trimethylation|up regulation of histone H3-K4 trimethylation|up-regulation of histone H3-K4 trimethylation|upregulation of histone H3-K4 trimethylation True http://purl.obolibrary.org/obo/GO_1905437 GO:2000892 biolink:BiologicalProcess cellobiose catabolic process The chemical reactions and pathways resulting in the breakdown of a cellobiose. go.json cellobiose catabolism http://purl.obolibrary.org/obo/GO_2000892 GO:1905438 biolink:BiologicalProcess non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Any non-canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. go.json beta-catenin-independent Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|beta-catenin-independent Wnt receptor signaling pathway involved in mDA neuron differentiation|beta-catenin-independent Wnt receptor signaling pathway involved in midbrain DA neurogenesis|beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|non-canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|non-canonical Wnt receptor signaling pathway involved in mDA neuron differentiation|non-canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis|non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|non-canonical Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|non-canonical Wnt receptor signalling pathway involved in mDA neuron differentiation|non-canonical Wnt receptor signalling pathway involved in midbrain DA neurogenesis|non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|non-canonical Wnt signaling pathway involved in mDA neuron differentiation|non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production|non-canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|non-canonical Wnt-activated signaling pathway involved in mDA neuron differentiation|non-canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis|non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1905438 GO:2000893 biolink:BiologicalProcess cellotriose metabolic process The chemical reactions and pathways involving a cellotriose. go.json cellotriose metabolism http://purl.obolibrary.org/obo/GO_2000893 GO:2000894 biolink:BiologicalProcess cellotriose catabolic process The chemical reactions and pathways resulting in the breakdown of a cellotriose. go.json cellotriose catabolism http://purl.obolibrary.org/obo/GO_2000894 GO:1905439 biolink:BiologicalProcess response to chondroitin 6'-sulfate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus. go.json http://purl.obolibrary.org/obo/GO_1905439 GO:2000895 biolink:BiologicalProcess hemicellulose catabolic process The chemical reactions and pathways resulting in the breakdown of a hemicellulose. go.json hemicellulose catabolism http://purl.obolibrary.org/obo/GO_2000895 GO:0051261 biolink:BiologicalProcess protein depolymerization The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. go.json protein polymer breakdown|protein polymer catabolic process|protein polymer catabolism|protein polymer degradation http://purl.obolibrary.org/obo/GO_0051261 goslim_pir GO:0051262 biolink:BiologicalProcess protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. go.json protein tetramer assembly|protein tetramer biosynthesis|protein tetramer biosynthetic process|protein tetramer formation http://purl.obolibrary.org/obo/GO_0051262 GO:0051260 biolink:BiologicalProcess protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. go.json protein homooligomer assembly|protein homooligomer biosynthesis|protein homooligomer biosynthetic process|protein homooligomer formation|protein homooligomerization activity http://purl.obolibrary.org/obo/GO_0051260 GO:0051265 biolink:MolecularActivity diolein transacylation activity Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. go.json DOG transacylation|acyl-CoA-independent diolein transacylation|dioleoylglycerol O-acyltransferase activity|dioleoylglycerol transacylase activity http://purl.obolibrary.org/obo/GO_0051265 GO:0075210 biolink:BiologicalProcess symbiont-mediated suppression of host cAMP-mediated signal transduction A process in which a virus interferes with, inhibits or disrupts a cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host cAMP-mediated signal transduction|negative regulation by symbiont of host cAMP-mediated signal transduction|negative regulation by symbiont of host cAMP-mediated signaling|suppression by symbiont of host cAMP-mediated signal transduction http://purl.obolibrary.org/obo/GO_0075210 GO:0051266 biolink:MolecularActivity sirohydrochlorin ferrochelatase activity Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. EC:4.99.1.4|KEGG_REACTION:R02864|MetaCyc:SIROHEME-FERROCHELAT-RXN|RHEA:24360 go.json siroheme ferro-lyase (sirohydrochlorin-forming)|siroheme synthase activity|sirohydrochlorin ferro-lyase activity http://purl.obolibrary.org/obo/GO_0051266 GO:0075211 biolink:BiologicalProcess obsolete regulation of transmembrane receptor-mediated cAMP signaling in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host|regulation of transmembrane receptor-mediated cAMP signal transduction in response to host|regulation of transmembrane receptor-mediated cAMP signalling in response to host True http://purl.obolibrary.org/obo/GO_0075211 GO:0075212 biolink:BiologicalProcess obsolete positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075212 GO:0051263 biolink:BiologicalProcess obsolete microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine OBSOLETE. The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain. go.json microcin E492 anabolism by siderophore ester modification of peptidyl-serine|microcin E492 formation by siderophore ester modification of peptidyl-serine|microcin E492 synthesis by siderophore ester modification of peptidyl-serine True http://purl.obolibrary.org/obo/GO_0051263 GO:0051264 biolink:MolecularActivity mono-olein transacylation activity Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. go.json MOG transacylation|acyl-CoA-independent mono-olein transacylation|mono-oleoylglycerol O-acyltransferase activity|mono-oleoylglycerol transacylase activity|monoolein transacylation|monooleoylglycerol O-acyltransferase activity|monooleoylglycerol transacylase activity http://purl.obolibrary.org/obo/GO_0051264 GO:0075213 biolink:BiologicalProcess obsolete negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host True http://purl.obolibrary.org/obo/GO_0075213 GO:2000827 biolink:BiologicalProcess mitochondrial RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion. go.json RNA quality control in mitochondria|RNA quality control in mitochondrion|RNA surveillance in mitochondria|aberrant RNA catabolic process in mitochondria|aberrant RNA catabolic process in mitochondrion http://purl.obolibrary.org/obo/GO_2000827 GO:0075247 biolink:BiologicalProcess aeciospore formation The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host. go.json http://purl.obolibrary.org/obo/GO_0075247 GO:2000828 biolink:BiologicalProcess regulation of parathyroid hormone secretion Any process that modulates the frequency, rate or extent of parathyroid hormone secretion. go.json regulation of PTH secretion|regulation of parathormone secretion|regulation of parathyrin secretion http://purl.obolibrary.org/obo/GO_2000828 GO:0075248 biolink:BiologicalProcess regulation of aeciospore formation Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium. go.json http://purl.obolibrary.org/obo/GO_0075248 GO:2000829 biolink:BiologicalProcess negative regulation of parathyroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion. go.json negative regulation of PTH secretion|negative regulation of parathormone secretion|negative regulation of parathyrin secretion http://purl.obolibrary.org/obo/GO_2000829 GO:0051278 biolink:BiologicalProcess fungal-type cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall. go.json cell wall polysaccharide anabolism|cell wall polysaccharide formation|cell wall polysaccharide synthesis|chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0051278 GO:0075249 biolink:BiologicalProcess positive regulation of aeciospore formation Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium. go.json http://purl.obolibrary.org/obo/GO_0075249 GO:0051279 biolink:BiologicalProcess regulation of release of sequestered calcium ion into cytosol Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. go.json regulation of calcium ion (Ca2+) mobilization|regulation of calcium mobilization|regulation of cytoplasmic release of sequestered calcium ion (Ca2+)|regulation of cytoplasmic release of stored calcium ion (Ca2+)|regulation of release of sequestered calcium ion (Ca2+)|regulation of release of stored calcium ion (Ca2+)|regulation of release of stored calcium ion (Ca2+) into cytoplasm|regulation of release of stored calcium ion (Ca2+) into cytosol http://purl.obolibrary.org/obo/GO_0051279 GO:2000820 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation. go.json down regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|down regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|down regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|down regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|down-regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|down-regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|down-regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|down-regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|downregulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|downregulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|downregulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|downregulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|inhibition of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|inhibition of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|inhibition of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|inhibition of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|negative regulation of global transcription from Pol II promoter involved in nonstriated muscle cell differentiation|negative regulation of global transcription from Pol II promoter involved in smooth muscle cell differentiation|negative regulation of transcription from Pol II promoter involved in nonstriated muscle cell differentiation|negative regulation of transcription from Pol II promoter involved in smooth muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter, global involved in nonstriated muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter, global involved in smooth muscle cell differentiation True http://purl.obolibrary.org/obo/GO_2000820 GO:2000821 biolink:BiologicalProcess regulation of grooming behavior Any process that modulates the frequency, rate or extent of grooming behavior. go.json regulation of grooming behaviour http://purl.obolibrary.org/obo/GO_2000821 GO:1905450 biolink:BiologicalProcess negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. go.json down regulation of Fc gamma receptor-dependent phagocytosis|down regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|down regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|down regulation of Fcgamma receptor-mediated phagocytosis|down regulation of IgG-mediated phagocytosis|down-regulation of Fc gamma receptor-dependent phagocytosis|down-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|down-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|down-regulation of Fcgamma receptor-mediated phagocytosis|down-regulation of IgG-mediated phagocytosis|downregulation of Fc gamma receptor-dependent phagocytosis|downregulation of Fc-gamma receptor signaling pathway involved in phagocytosis|downregulation of Fc-gamma receptor signalling pathway involved in phagocytosis|downregulation of Fcgamma receptor-mediated phagocytosis|downregulation of IgG-mediated phagocytosis|inhibition of Fc gamma receptor-dependent phagocytosis|inhibition of Fc-gamma receptor signaling pathway involved in phagocytosis|inhibition of Fc-gamma receptor signalling pathway involved in phagocytosis|inhibition of Fcgamma receptor-mediated phagocytosis|inhibition of IgG-mediated phagocytosis|negative regulation of Fc gamma receptor-dependent phagocytosis|negative regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|negative regulation of Fcgamma receptor-mediated phagocytosis|negative regulation of IgG-mediated phagocytosis http://purl.obolibrary.org/obo/GO_1905450 GO:2000822 biolink:BiologicalProcess regulation of behavioral fear response Any process that modulates the frequency, rate or extent of behavioral fear response. go.json regulation of behavioural fear response http://purl.obolibrary.org/obo/GO_2000822 GO:1905451 biolink:BiologicalProcess positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. go.json activation of Fc gamma receptor-dependent phagocytosis|activation of Fc-gamma receptor signaling pathway involved in phagocytosis|activation of Fc-gamma receptor signalling pathway involved in phagocytosis|activation of Fcgamma receptor-mediated phagocytosis|activation of IgG-mediated phagocytosis|positive regulation of Fc gamma receptor-dependent phagocytosis|positive regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|positive regulation of Fcgamma receptor-mediated phagocytosis|positive regulation of IgG-mediated phagocytosis|up regulation of Fc gamma receptor-dependent phagocytosis|up regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|up regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|up regulation of Fcgamma receptor-mediated phagocytosis|up regulation of IgG-mediated phagocytosis|up-regulation of Fc gamma receptor-dependent phagocytosis|up-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|up-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|up-regulation of Fcgamma receptor-mediated phagocytosis|up-regulation of IgG-mediated phagocytosis|upregulation of Fc gamma receptor-dependent phagocytosis|upregulation of Fc-gamma receptor signaling pathway involved in phagocytosis|upregulation of Fc-gamma receptor signalling pathway involved in phagocytosis|upregulation of Fcgamma receptor-mediated phagocytosis|upregulation of IgG-mediated phagocytosis http://purl.obolibrary.org/obo/GO_1905451 GO:2000823 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000823 GO:1905452 biolink:BiologicalProcess obsolete canonical Wnt signaling pathway involved in regulation of stem cell proliferation OBSOLETE. Any canonical Wnt signaling pathway that is involved in regulation of stem cell proliferation. go.json Wnt receptor signaling pathway through beta-catenin involved in regulation of stem cell proliferation|Wnt receptor signaling pathway via beta-catenin involved in regulation of stem cell proliferation|Wnt receptor signalling pathway through beta-catenin involved in regulation of stem cell proliferation|canonical Wnt receptor signaling pathway involved in regulation of stem cell proliferation|canonical Wnt-activated signaling pathway involved in regulation of stem cell proliferation|frizzled-1 receptor signaling pathway involved in regulation of stem cell proliferation True http://purl.obolibrary.org/obo/GO_1905452 GO:2000824 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000824 GO:1905453 biolink:BiologicalProcess regulation of myeloid progenitor cell differentiation Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1905453 GO:2000825 biolink:BiologicalProcess positive regulation of androgen receptor activity Any process that activates or increases the frequency, rate or extent of androgen receptor activity. go.json http://purl.obolibrary.org/obo/GO_2000825 gocheck_do_not_annotate GO:1905454 biolink:BiologicalProcess negative regulation of myeloid progenitor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. go.json down regulation of myeloid progenitor cell differentiation|down-regulation of myeloid progenitor cell differentiation|downregulation of myeloid progenitor cell differentiation|inhibition of myeloid progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1905454 GO:2000826 biolink:BiologicalProcess regulation of heart morphogenesis Any process that modulates the frequency, rate or extent of heart morphogenesis. go.json regulation of cardiac morphogenesis http://purl.obolibrary.org/obo/GO_2000826 GO:1905444 biolink:BiologicalProcess negative regulation of clathrin coat assembly Any process that stops, prevents or reduces the frequency, rate or extent of clathrin coat assembly. go.json down regulation of clathrin cage assembly|down regulation of clathrin coat assembly|down-regulation of clathrin cage assembly|down-regulation of clathrin coat assembly|downregulation of clathrin cage assembly|downregulation of clathrin coat assembly|inhibition of clathrin cage assembly|inhibition of clathrin coat assembly|negative regulation of clathrin cage assembly http://purl.obolibrary.org/obo/GO_1905444 GO:1905445 biolink:BiologicalProcess positive regulation of clathrin coat assembly Any process that activates or increases the frequency, rate or extent of clathrin coat assembly. go.json activation of clathrin cage assembly|activation of clathrin coat assembly|positive regulation of clathrin cage assembly|up regulation of clathrin cage assembly|up regulation of clathrin coat assembly|up-regulation of clathrin cage assembly|up-regulation of clathrin coat assembly|upregulation of clathrin cage assembly|upregulation of clathrin coat assembly http://purl.obolibrary.org/obo/GO_1905445 GO:1905446 biolink:BiologicalProcess regulation of mitochondrial ATP synthesis coupled electron transport Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. go.json regulation of mitochondrial electron transport|regulation of organelle ATP synthesis coupled electron transport http://purl.obolibrary.org/obo/GO_1905446 GO:1905447 biolink:BiologicalProcess negative regulation of mitochondrial ATP synthesis coupled electron transport Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. go.json down regulation of mitochondrial ATP synthesis coupled electron transport|down-regulation of mitochondrial ATP synthesis coupled electron transport|downregulation of mitochondrial ATP synthesis coupled electron transport|inhibition of mitochondrial ATP synthesis coupled electron transport http://purl.obolibrary.org/obo/GO_1905447 GO:1905448 biolink:BiologicalProcess positive regulation of mitochondrial ATP synthesis coupled electron transport Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. go.json activation of mitochondrial ATP synthesis coupled electron transport|up regulation of mitochondrial ATP synthesis coupled electron transport|up-regulation of mitochondrial ATP synthesis coupled electron transport|upregulation of mitochondrial ATP synthesis coupled electron transport http://purl.obolibrary.org/obo/GO_1905448 GO:1905449 biolink:BiologicalProcess regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Any process that modulates the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. go.json regulation of Fc gamma receptor-dependent phagocytosis|regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|regulation of Fcgamma receptor-mediated phagocytosis|regulation of IgG-mediated phagocytosis http://purl.obolibrary.org/obo/GO_1905449 GO:0051272 biolink:BiologicalProcess obsolete positive regulation of cellular component movement OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a cellular component. go.json positive regulation of cellular component motion True http://purl.obolibrary.org/obo/GO_0051272 GO:0051273 biolink:BiologicalProcess beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds. go.json beta-glucan metabolism http://purl.obolibrary.org/obo/GO_0051273 GO:0075240 biolink:BiologicalProcess regulation of zoospore formation Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. go.json http://purl.obolibrary.org/obo/GO_0075240 GO:0075241 biolink:BiologicalProcess positive regulation of zoospore formation Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. go.json http://purl.obolibrary.org/obo/GO_0075241 GO:0051270 biolink:BiologicalProcess obsolete regulation of cellular component movement OBSOLETE. Any process that modulates the frequency, rate or extent of the movement of a cellular component. go.json regulation of cell movement|regulation of cellular component motion True http://purl.obolibrary.org/obo/GO_0051270 GO:0051271 biolink:BiologicalProcess obsolete negative regulation of cellular component movement OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component. go.json negative regulation of cellular component motion True http://purl.obolibrary.org/obo/GO_0051271 GO:0075242 biolink:BiologicalProcess negative regulation of zoospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. go.json http://purl.obolibrary.org/obo/GO_0075242 GO:0051276 biolink:BiologicalProcess chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. go.json DNA condensation|DNA packaging|chromosome organisation|chromosome organization and biogenesis|maintenance of genome integrity|nuclear genome maintenance http://purl.obolibrary.org/obo/GO_0051276 goslim_chembl|goslim_drosophila|goslim_pir GO:0075243 biolink:BiologicalProcess oospore formation The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of Oomycetes and certain algae and fungi. go.json http://purl.obolibrary.org/obo/GO_0075243 GO:0075244 biolink:BiologicalProcess regulation of oospore formation Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes. go.json http://purl.obolibrary.org/obo/GO_0075244 GO:0051277 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051277 GO:0051274 biolink:BiologicalProcess beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans. go.json beta-glucan anabolism|beta-glucan biosynthesis|beta-glucan formation|beta-glucan synthesis http://purl.obolibrary.org/obo/GO_0051274 GO:0075245 biolink:BiologicalProcess positive regulation of oospore formation Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes. go.json http://purl.obolibrary.org/obo/GO_0075245 GO:0051275 biolink:BiologicalProcess beta-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of beta-glucans. go.json beta-glucan breakdown|beta-glucan catabolism|beta-glucan degradation http://purl.obolibrary.org/obo/GO_0051275 GO:0075246 biolink:BiologicalProcess negative regulation of oospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes. go.json http://purl.obolibrary.org/obo/GO_0075246 GO:0075236 biolink:BiologicalProcess obsolete positive regulation of zoospore movement on or near host OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075236 GO:2000838 biolink:BiologicalProcess negative regulation of androstenedione secretion Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion. go.json negative regulation of androst-4-ene-3,17-dione secretion http://purl.obolibrary.org/obo/GO_2000838 GO:2000839 biolink:BiologicalProcess positive regulation of androstenedione secretion Any process that activates or increases the frequency, rate or extent of androstenedione secretion. go.json positive regulation of androst-4-ene-3,17-dione secretion http://purl.obolibrary.org/obo/GO_2000839 GO:0075237 biolink:BiologicalProcess obsolete obsolete negative regulation of zoospore movement on or near host OBSOLETE. OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075237 GO:0075238 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075238 GO:0051289 biolink:BiologicalProcess protein homotetramerization The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. go.json protein homotetramer assembly|protein homotetramer biosynthesis|protein homotetramer biosynthetic process|protein homotetramer formation http://purl.obolibrary.org/obo/GO_0051289 GO:0075239 biolink:BiologicalProcess zoospore formation The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. go.json http://purl.obolibrary.org/obo/GO_0075239 GO:2000830 biolink:BiologicalProcess positive regulation of parathyroid hormone secretion Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion. go.json positive regulation of PTH secretion|positive regulation of parathormone secretion|positive regulation of parathyrin secretion http://purl.obolibrary.org/obo/GO_2000830 GO:2000831 biolink:BiologicalProcess regulation of steroid hormone secretion Any process that modulates the frequency, rate or extent of steroid hormone secretion. go.json http://purl.obolibrary.org/obo/GO_2000831 GO:1905460 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. go.json down regulation of VSMC apoptosis|down regulation of VSMC apoptotic process|down regulation of vascular associated smooth muscle cell apoptosis|down regulation of vascular associated smooth muscle cell apoptotic process|down regulation of vascular smooth muscle cell apoptosis|down regulation of vascular smooth muscle cell apoptotic process|down-regulation of VSMC apoptosis|down-regulation of VSMC apoptotic process|down-regulation of vascular associated smooth muscle cell apoptosis|down-regulation of vascular associated smooth muscle cell apoptotic process|down-regulation of vascular smooth muscle cell apoptosis|down-regulation of vascular smooth muscle cell apoptotic process|downregulation of VSMC apoptosis|downregulation of VSMC apoptotic process|downregulation of vascular associated smooth muscle cell apoptosis|downregulation of vascular associated smooth muscle cell apoptotic process|downregulation of vascular smooth muscle cell apoptosis|downregulation of vascular smooth muscle cell apoptotic process|inhibition of VSMC apoptosis|inhibition of VSMC apoptotic process|inhibition of vascular associated smooth muscle cell apoptosis|inhibition of vascular associated smooth muscle cell apoptotic process|inhibition of vascular smooth muscle cell apoptosis|inhibition of vascular smooth muscle cell apoptotic process|negative regulation of VSMC apoptosis|negative regulation of VSMC apoptotic process|negative regulation of vascular associated smooth muscle cell apoptosis|negative regulation of vascular smooth muscle cell apoptosis|negative regulation of vascular smooth muscle cell apoptotic process http://purl.obolibrary.org/obo/GO_1905460 GO:2000832 biolink:BiologicalProcess negative regulation of steroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. go.json http://purl.obolibrary.org/obo/GO_2000832 GO:1905461 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle cell apoptotic process Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. go.json activation of VSMC apoptosis|activation of VSMC apoptotic process|activation of vascular associated smooth muscle cell apoptosis|activation of vascular associated smooth muscle cell apoptotic process|activation of vascular smooth muscle cell apoptosis|activation of vascular smooth muscle cell apoptotic process|positive regulation of VSMC apoptosis|positive regulation of VSMC apoptotic process|positive regulation of vascular associated smooth muscle cell apoptosis|positive regulation of vascular smooth muscle cell apoptosis|positive regulation of vascular smooth muscle cell apoptotic process|up regulation of VSMC apoptosis|up regulation of VSMC apoptotic process|up regulation of vascular associated smooth muscle cell apoptosis|up regulation of vascular associated smooth muscle cell apoptotic process|up regulation of vascular smooth muscle cell apoptosis|up regulation of vascular smooth muscle cell apoptotic process|up-regulation of VSMC apoptosis|up-regulation of VSMC apoptotic process|up-regulation of vascular associated smooth muscle cell apoptosis|up-regulation of vascular associated smooth muscle cell apoptotic process|up-regulation of vascular smooth muscle cell apoptosis|up-regulation of vascular smooth muscle cell apoptotic process|upregulation of VSMC apoptosis|upregulation of VSMC apoptotic process|upregulation of vascular associated smooth muscle cell apoptosis|upregulation of vascular associated smooth muscle cell apoptotic process|upregulation of vascular smooth muscle cell apoptosis|upregulation of vascular smooth muscle cell apoptotic process http://purl.obolibrary.org/obo/GO_1905461 GO:2000833 biolink:BiologicalProcess positive regulation of steroid hormone secretion Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. go.json http://purl.obolibrary.org/obo/GO_2000833 GO:1905462 biolink:BiologicalProcess regulation of DNA duplex unwinding Any process that modulates the frequency, rate or extent of DNA duplex unwinding. go.json regulation of DNA unwinding|regulation of duplex DNA melting http://purl.obolibrary.org/obo/GO_1905462 GO:2000834 biolink:BiologicalProcess regulation of androgen secretion Any process that modulates the frequency, rate or extent of androgen secretion. go.json http://purl.obolibrary.org/obo/GO_2000834 GO:1905463 biolink:BiologicalProcess negative regulation of DNA duplex unwinding Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding. go.json down regulation of DNA duplex unwinding|down regulation of DNA unwinding|down regulation of duplex DNA melting|down-regulation of DNA duplex unwinding|down-regulation of DNA unwinding|down-regulation of duplex DNA melting|downregulation of DNA duplex unwinding|downregulation of DNA unwinding|downregulation of duplex DNA melting|inhibition of DNA duplex unwinding|inhibition of DNA unwinding|inhibition of duplex DNA melting|negative regulation of DNA unwinding|negative regulation of duplex DNA melting http://purl.obolibrary.org/obo/GO_1905463 GO:2000835 biolink:BiologicalProcess negative regulation of androgen secretion Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. go.json http://purl.obolibrary.org/obo/GO_2000835 GO:1905464 biolink:BiologicalProcess positive regulation of DNA duplex unwinding Any process that activates or increases the frequency, rate or extent of DNA duplex unwinding. go.json activation of DNA duplex unwinding|activation of DNA unwinding|activation of duplex DNA melting|positive regulation of DNA unwinding|positive regulation of duplex DNA melting|up regulation of DNA duplex unwinding|up regulation of DNA unwinding|up regulation of duplex DNA melting|up-regulation of DNA duplex unwinding|up-regulation of DNA unwinding|up-regulation of duplex DNA melting|upregulation of DNA duplex unwinding|upregulation of DNA unwinding|upregulation of duplex DNA melting http://purl.obolibrary.org/obo/GO_1905464 GO:2000836 biolink:BiologicalProcess positive regulation of androgen secretion Any process that activates or increases the frequency, rate or extent of androgen secretion. go.json http://purl.obolibrary.org/obo/GO_2000836 GO:2000837 biolink:BiologicalProcess regulation of androstenedione secretion Any process that modulates the frequency, rate or extent of androstenedione secretion. go.json regulation of androst-4-ene-3,17-dione secretion http://purl.obolibrary.org/obo/GO_2000837 GO:1905465 biolink:BiologicalProcess regulation of G-quadruplex DNA unwinding Any process that modulates the frequency, rate or extent of G-quadruplex DNA unwinding. go.json http://purl.obolibrary.org/obo/GO_1905465 GO:1905455 biolink:BiologicalProcess positive regulation of myeloid progenitor cell differentiation Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. go.json activation of myeloid progenitor cell differentiation|up regulation of myeloid progenitor cell differentiation|up-regulation of myeloid progenitor cell differentiation|upregulation of myeloid progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1905455 GO:1905456 biolink:BiologicalProcess regulation of lymphoid progenitor cell differentiation Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1905456 GO:1905457 biolink:BiologicalProcess negative regulation of lymphoid progenitor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation. go.json down regulation of lymphoid progenitor cell differentiation|down-regulation of lymphoid progenitor cell differentiation|downregulation of lymphoid progenitor cell differentiation|inhibition of lymphoid progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1905457 GO:1905458 biolink:BiologicalProcess positive regulation of lymphoid progenitor cell differentiation Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation. go.json activation of lymphoid progenitor cell differentiation|up regulation of lymphoid progenitor cell differentiation|up-regulation of lymphoid progenitor cell differentiation|upregulation of lymphoid progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1905458 GO:1905459 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell apoptotic process Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. go.json regulation of VSMC apoptosis|regulation of VSMC apoptotic process|regulation of vascular associated smooth muscle cell apoptosis|regulation of vascular smooth muscle cell apoptosis|regulation of vascular smooth muscle cell apoptotic process http://purl.obolibrary.org/obo/GO_1905459 GO:0051280 biolink:BiologicalProcess negative regulation of release of sequestered calcium ion into cytosol Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. go.json down regulation of release of sequestered calcium ion into cytosol|down-regulation of release of sequestered calcium ion into cytosol|downregulation of release of sequestered calcium ion into cytosol|inhibition of release of sequestered calcium ion into cytosol|negative regulation of calcium ion (Ca2+) mobilization|negative regulation of calcium mobilization|negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)|negative regulation of cytoplasmic release of stored calcium ion (Ca2+)|negative regulation of cytosolic release of sequestered calcium ion (Ca2+)|negative regulation of cytosolic release of stored calcium ion (Ca2+)|negative regulation of release of sequestered calcium ion (Ca2+)|negative regulation of release of sequestered calcium ion into cytoplasm|negative regulation of release of stored calcium ion (Ca2+)|negative regulation of release of stored calcium ion (Ca2+) into cytoplasm|negative regulation of release of stored calcium ion (Ca2+) into cytosol http://purl.obolibrary.org/obo/GO_0051280 GO:0051283 biolink:BiologicalProcess negative regulation of sequestering of calcium ion Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. go.json down regulation of sequestering of calcium ion|down-regulation of sequestering of calcium ion|downregulation of sequestering of calcium ion|inhibition of sequestering of calcium ion|negative regulation of calcium ion (Ca2+) retention|negative regulation of calcium ion (Ca2+) sequestering|negative regulation of calcium ion (Ca2+) sequestration|negative regulation of calcium ion (Ca2+) storage|negative regulation of retention of calcium ion (Ca2+)|negative regulation of sequestering of calcium ion (Ca2+)|negative regulation of sequestration of calcium ion (Ca2+)|negative regulation of storage of calcium ion (Ca2+) http://purl.obolibrary.org/obo/GO_0051283 GO:0051284 biolink:BiologicalProcess positive regulation of sequestering of calcium ion Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. go.json activation of sequestering of calcium ion|positive regulation of calcium ion (Ca2+) retention|positive regulation of calcium ion (Ca2+) sequestering|positive regulation of calcium ion (Ca2+) sequestration|positive regulation of calcium ion (Ca2+) storage|positive regulation of retention of calcium ion (Ca2+)|positive regulation of sequestering of calcium ion (Ca2+)|positive regulation of sequestration of calcium ion (Ca2+)|positive regulation of storage of calcium ion (Ca2+)|stimulation of sequestering of calcium ion|up regulation of sequestering of calcium ion|up-regulation of sequestering of calcium ion|upregulation of sequestering of calcium ion http://purl.obolibrary.org/obo/GO_0051284 GO:0051281 biolink:BiologicalProcess positive regulation of release of sequestered calcium ion into cytosol Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. go.json activation of release of sequestered calcium ion into cytosol|positive regulation of calcium ion (Ca2+) mobilization|positive regulation of calcium mobilization|positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)|positive regulation of cytoplasmic release of stored calcium ion (Ca2+)|positive regulation of cytosolic release of sequestered calcium ion (Ca2+)|positive regulation of cytosolic release of stored calcium ion (Ca2+)|positive regulation of release of sequestered calcium ion (Ca2+)|positive regulation of release of sequestered calcium ion into cytoplasm|positive regulation of release of stored calcium ion (Ca2+)|positive regulation of release of stored calcium ion (Ca2+) into cytoplasm|positive regulation of release of stored calcium ion (Ca2+) into cytosol|stimulation of release of sequestered calcium ion into cytosol|up regulation of release of sequestered calcium ion into cytosol|up-regulation of release of sequestered calcium ion into cytosol|upregulation of release of sequestered calcium ion into cytosol http://purl.obolibrary.org/obo/GO_0051281 GO:0075230 biolink:BiologicalProcess obsolete spore movement on or near host OBSOLETE. Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075230 GO:0051282 biolink:BiologicalProcess regulation of sequestering of calcium ion Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. go.json regulation of calcium ion (Ca2+) retention|regulation of calcium ion (Ca2+) sequestering|regulation of calcium ion (Ca2+) sequestration|regulation of calcium ion (Ca2+) storage|regulation of retention of calcium ion (Ca2+)|regulation of sequestering of calcium ion (Ca2+)|regulation of sequestration of calcium ion (Ca2+)|regulation of storage of calcium ion (Ca2+) http://purl.obolibrary.org/obo/GO_0051282 GO:0075231 biolink:BiologicalProcess obsolete modulation of spore movement on or near host OBSOLETE. Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075231 GO:0051287 biolink:MolecularActivity NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. go.json NAD or NADH binding|NAD+ or NADH binding|nicotinamide adenine dinucleotide binding http://purl.obolibrary.org/obo/GO_0051287 goslim_chembl GO:0075232 biolink:BiologicalProcess obsolete positive regulation of spore movement on or near host OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075232 GO:0075233 biolink:BiologicalProcess obsolete negative regulation of spore movement on or near host OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075233 GO:0051288 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051288 GO:0075234 biolink:BiologicalProcess obsolete zoospore movement on or near host OBSOLETE. Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json zoospore motility on or near host True http://purl.obolibrary.org/obo/GO_0075234 GO:0051285 biolink:CellularComponent cell cortex of cell tip The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell. go.json cell cortex of cell end http://purl.obolibrary.org/obo/GO_0051285 GO:0075235 biolink:BiologicalProcess obsolete modulation of zoospore movement on or near host OBSOLETE. Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation of zoospore motility on or near host True http://purl.obolibrary.org/obo/GO_0075235 GO:0051286 biolink:CellularComponent cell tip The region at the end of the longest axis of a cylindrical or elongated cell. go.json cell end http://purl.obolibrary.org/obo/GO_0051286 GO:0075269 biolink:BiologicalProcess positive regulation of aecium development Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed. go.json http://purl.obolibrary.org/obo/GO_0075269 GO:2000849 biolink:BiologicalProcess regulation of glucocorticoid secretion Any process that modulates the frequency, rate or extent of glucocorticoid secretion. go.json http://purl.obolibrary.org/obo/GO_2000849 GO:2000841 biolink:BiologicalProcess negative regulation of dehydroepiandrosterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion. go.json negative regulation of 3beta-hydroxyandrost-5-en-17-one secretion|negative regulation of DHEA secretion|negative regulation of dehydroisoandrosterone secretion http://purl.obolibrary.org/obo/GO_2000841 GO:1905470 biolink:BiologicalProcess obsolete positive regulation of clathrin-coated pit assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly. go.json activation of clathrin-coated pit assembly|activation of clathrin-coated pit formation|activation of coated pit assembly|activation of coated pit formation|positive regulation of clathrin-coated pit formation|positive regulation of coated pit assembly|positive regulation of coated pit formation|up regulation of clathrin-coated pit assembly|up regulation of clathrin-coated pit formation|up regulation of coated pit assembly|up regulation of coated pit formation|up-regulation of clathrin-coated pit assembly|up-regulation of clathrin-coated pit formation|up-regulation of coated pit assembly|up-regulation of coated pit formation|upregulation of clathrin-coated pit assembly|upregulation of clathrin-coated pit formation|upregulation of coated pit assembly|upregulation of coated pit formation True http://purl.obolibrary.org/obo/GO_1905470 GO:2000842 biolink:BiologicalProcess positive regulation of dehydroepiandrosterone secretion Any process that activates or increases the frequency, rate or extent of dehydroepiandrosterone secretion. go.json positive regulation of 3beta-hydroxyandrost-5-en-17-one secretion|positive regulation of DHEA secretion|positive regulation of dehydroisoandrosterone secretion http://purl.obolibrary.org/obo/GO_2000842 GO:1905471 biolink:BiologicalProcess obsolete regulation of histone H3-K79 dimethylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K79 dimethylation. go.json regulation of histone H3 K79 dimethylation|regulation of histone lysine H3 K79 dimethylation True http://purl.obolibrary.org/obo/GO_1905471 GO:2000843 biolink:BiologicalProcess regulation of testosterone secretion Any process that modulates the frequency, rate or extent of testosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000843 GO:1905472 biolink:BiologicalProcess obsolete negative regulation of histone H3-K79 dimethylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 dimethylation. go.json down regulation of histone H3 K79 dimethylation|down regulation of histone H3-K79 dimethylation|down regulation of histone lysine H3 K79 dimethylation|down-regulation of histone H3 K79 dimethylation|down-regulation of histone H3-K79 dimethylation|down-regulation of histone lysine H3 K79 dimethylation|downregulation of histone H3 K79 dimethylation|downregulation of histone H3-K79 dimethylation|downregulation of histone lysine H3 K79 dimethylation|inhibition of histone H3 K79 dimethylation|inhibition of histone H3-K79 dimethylation|inhibition of histone lysine H3 K79 dimethylation|negative regulation of histone H3 K79 dimethylation|negative regulation of histone lysine H3 K79 dimethylation True http://purl.obolibrary.org/obo/GO_1905472 GO:2000844 biolink:BiologicalProcess negative regulation of testosterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000844 GO:1905473 biolink:BiologicalProcess obsolete positive regulation of histone H3-K79 dimethylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K79 dimethylation. go.json activation of histone H3 K79 dimethylation|activation of histone H3-K79 dimethylation|activation of histone lysine H3 K79 dimethylation|positive regulation of histone H3 K79 dimethylation|positive regulation of histone lysine H3 K79 dimethylation|up regulation of histone H3 K79 dimethylation|up regulation of histone H3-K79 dimethylation|up regulation of histone lysine H3 K79 dimethylation|up-regulation of histone H3 K79 dimethylation|up-regulation of histone H3-K79 dimethylation|up-regulation of histone lysine H3 K79 dimethylation|upregulation of histone H3 K79 dimethylation|upregulation of histone H3-K79 dimethylation|upregulation of histone lysine H3 K79 dimethylation True http://purl.obolibrary.org/obo/GO_1905473 GO:2000845 biolink:BiologicalProcess positive regulation of testosterone secretion Any process that activates or increases the frequency, rate or extent of testosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000845 GO:1905474 biolink:BiologicalProcess canonical Wnt signaling pathway involved in stem cell proliferation Any canonical Wnt signaling pathway that is involved in stem cell proliferation. go.json Wnt receptor signaling pathway through beta-catenin involved in stem cell proliferation|Wnt receptor signaling pathway via beta-catenin involved in stem cell proliferation|Wnt receptor signalling pathway through beta-catenin involved in stem cell proliferation|canonical Wnt receptor signaling pathway involved in stem cell proliferation|canonical Wnt-activated signaling pathway involved in stem cell proliferation|frizzled-1 receptor signaling pathway involved in stem cell proliferation http://purl.obolibrary.org/obo/GO_1905474 GO:2000846 biolink:BiologicalProcess regulation of corticosteroid hormone secretion Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. go.json regulation of corticosteroid secretion http://purl.obolibrary.org/obo/GO_2000846 GO:1905475 biolink:BiologicalProcess regulation of protein localization to membrane Any process that modulates the frequency, rate or extent of protein localization to membrane. go.json regulation of protein localisation in membrane|regulation of protein localization in membrane http://purl.obolibrary.org/obo/GO_1905475 GO:2000847 biolink:BiologicalProcess negative regulation of corticosteroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion. go.json negative regulation of corticosteroid secretion http://purl.obolibrary.org/obo/GO_2000847 GO:1905476 biolink:BiologicalProcess negative regulation of protein localization to membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. go.json down regulation of protein localisation in membrane|down regulation of protein localization in membrane|down regulation of protein localization to membrane|down-regulation of protein localisation in membrane|down-regulation of protein localization in membrane|down-regulation of protein localization to membrane|downregulation of protein localisation in membrane|downregulation of protein localization in membrane|downregulation of protein localization to membrane|inhibition of protein localisation in membrane|inhibition of protein localization in membrane|inhibition of protein localization to membrane|negative regulation of protein localisation in membrane|negative regulation of protein localization in membrane http://purl.obolibrary.org/obo/GO_1905476 GO:2000848 biolink:BiologicalProcess positive regulation of corticosteroid hormone secretion Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. go.json positive regulation of corticosteroid secretion http://purl.obolibrary.org/obo/GO_2000848 GO:1905466 biolink:BiologicalProcess negative regulation of G-quadruplex DNA unwinding Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA unwinding. go.json down regulation of G-quadruplex DNA unwinding|down-regulation of G-quadruplex DNA unwinding|downregulation of G-quadruplex DNA unwinding|inhibition of G-quadruplex DNA unwinding http://purl.obolibrary.org/obo/GO_1905466 GO:1905467 biolink:BiologicalProcess positive regulation of G-quadruplex DNA unwinding Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA unwinding. go.json activation of G-quadruplex DNA unwinding|up regulation of G-quadruplex DNA unwinding|up-regulation of G-quadruplex DNA unwinding|upregulation of G-quadruplex DNA unwinding http://purl.obolibrary.org/obo/GO_1905467 GO:1905468 biolink:BiologicalProcess obsolete regulation of clathrin-coated pit assembly OBSOLETE. Any process that modulates the frequency, rate or extent of clathrin-coated pit assembly. go.json regulation of clathrin-coated pit formation|regulation of coated pit assembly|regulation of coated pit formation True http://purl.obolibrary.org/obo/GO_1905468 GO:1905469 biolink:BiologicalProcess obsolete negative regulation of clathrin-coated pit assembly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-coated pit assembly. go.json down regulation of clathrin-coated pit assembly|down regulation of clathrin-coated pit formation|down regulation of coated pit assembly|down regulation of coated pit formation|down-regulation of clathrin-coated pit assembly|down-regulation of clathrin-coated pit formation|down-regulation of coated pit assembly|down-regulation of coated pit formation|downregulation of clathrin-coated pit assembly|downregulation of clathrin-coated pit formation|downregulation of coated pit assembly|downregulation of coated pit formation|inhibition of clathrin-coated pit assembly|inhibition of clathrin-coated pit formation|inhibition of coated pit assembly|inhibition of coated pit formation|negative regulation of clathrin-coated pit formation|negative regulation of coated pit assembly|negative regulation of coated pit formation True http://purl.obolibrary.org/obo/GO_1905469 GO:0051290 biolink:BiologicalProcess protein heterotetramerization The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. go.json protein heterotetramer assembly|protein heterotetramer biosynthesis|protein heterotetramer biosynthetic process|protein heterotetramer formation http://purl.obolibrary.org/obo/GO_0051290 GO:0051291 biolink:BiologicalProcess protein heterooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. go.json protein heterooligomer assembly|protein heterooligomer biosynthesis|protein heterooligomer biosynthetic process|protein heterooligomer formation http://purl.obolibrary.org/obo/GO_0051291 GO:2000840 biolink:BiologicalProcess regulation of dehydroepiandrosterone secretion Any process that modulates the frequency, rate or extent of dehydroepiandrosterone secretion. go.json regulation of 3beta-hydroxyandrost-5-en-17-one secretion|regulation of DHEA secretion|regulation of dehydroisoandrosterone secretion http://purl.obolibrary.org/obo/GO_2000840 GO:0075260 biolink:BiologicalProcess regulation of spore-bearing organ development Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. go.json http://purl.obolibrary.org/obo/GO_0075260 GO:0051294 biolink:BiologicalProcess establishment of spindle orientation Any process that set the alignment of spindle relative to other cellular structures. go.json orienting of spindle|spindle orientation http://purl.obolibrary.org/obo/GO_0051294 GO:0075261 biolink:BiologicalProcess positive regulation of spore-bearing organ development Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. go.json http://purl.obolibrary.org/obo/GO_0075261 GO:0051295 biolink:BiologicalProcess establishment of meiotic spindle localization The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs. go.json establishment of meiotic spindle localisation|meiotic spindle positioning|spindle positioning during meiosis|spindle positioning involved in meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051295 GO:0075262 biolink:BiologicalProcess negative regulation of spore-bearing organ development Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. go.json http://purl.obolibrary.org/obo/GO_0075262 GO:0051292 biolink:BiologicalProcess nuclear pore complex assembly The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. go.json NPC assembly|nuclear pore assembly|nuclear pore biogenesis|nuclear pore biosynthesis|nuclear pore complex biogenesis|nuclear pore complex biosynthesis|nuclear pore complex formation|nuclear pore formation http://purl.obolibrary.org/obo/GO_0051292 GO:0075263 biolink:BiologicalProcess oogonium development The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes. go.json http://purl.obolibrary.org/obo/GO_0075263 GO:0051293 biolink:BiologicalProcess establishment of spindle localization The directed movement of the spindle to a specific location in the cell. go.json establishment of spindle localisation|spindle positioning http://purl.obolibrary.org/obo/GO_0051293 GO:0075264 biolink:BiologicalProcess regulation of oogonium development Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes. go.json http://purl.obolibrary.org/obo/GO_0075264 GO:0051298 biolink:BiologicalProcess centrosome duplication The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. go.json centrosome replication http://purl.obolibrary.org/obo/GO_0051298 GO:0075265 biolink:BiologicalProcess positive regulation of oogonium development Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes. go.json http://purl.obolibrary.org/obo/GO_0075265 GO:0075266 biolink:BiologicalProcess negative regulation of oogonium development Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes. go.json http://purl.obolibrary.org/obo/GO_0075266 GO:0051299 biolink:BiologicalProcess centrosome separation The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. go.json http://purl.obolibrary.org/obo/GO_0051299 GO:0051296 biolink:BiologicalProcess establishment of meiotic spindle orientation Any process that set the alignment of meiotic spindle relative to other cellular structures. go.json establishment of spindle orientation during meiosis|establishment of spindle orientation involved in meiotic cell cycle|meiotic spindle orientation|orienting of meiotic spindle http://purl.obolibrary.org/obo/GO_0051296 GO:0075267 biolink:BiologicalProcess aecium development The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium. go.json http://purl.obolibrary.org/obo/GO_0075267 GO:0075268 biolink:BiologicalProcess regulation of aecium development Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed. go.json http://purl.obolibrary.org/obo/GO_0075268 GO:0051297 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051297 GO:0075258 biolink:BiologicalProcess negative regulation of teliospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. go.json http://purl.obolibrary.org/obo/GO_0075258 GO:0075259 biolink:BiologicalProcess spore-bearing structure development The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores. go.json fruiting structure development|sporangium development|spore-bearing organ development|sporophore development http://purl.obolibrary.org/obo/GO_0075259 GO:1905480 biolink:BiologicalProcess obsolete positive regulation of glutamate-ammonia ligase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of glutamate-ammonia ligase activity. go.json activation of L-glutamate:ammonia ligase (ADP-forming)|activation of L-glutamine synthetase activity|activation of glutamate-ammonia ligase activity|activation of glutamine synthetase activity|activation of glutamylhydroxamic synthetase activity|positive regulation of L-glutamate:ammonia ligase (ADP-forming)|positive regulation of L-glutamine synthetase activity|positive regulation of glutamine synthetase activity|positive regulation of glutamylhydroxamic synthetase activity|up regulation of L-glutamate:ammonia ligase (ADP-forming)|up regulation of L-glutamine synthetase activity|up regulation of glutamate-ammonia ligase activity|up regulation of glutamine synthetase activity|up regulation of glutamylhydroxamic synthetase activity|up-regulation of L-glutamate:ammonia ligase (ADP-forming)|up-regulation of L-glutamine synthetase activity|up-regulation of glutamate-ammonia ligase activity|up-regulation of glutamine synthetase activity|up-regulation of glutamylhydroxamic synthetase activity|upregulation of L-glutamate:ammonia ligase (ADP-forming)|upregulation of L-glutamine synthetase activity|upregulation of glutamate-ammonia ligase activity|upregulation of glutamine synthetase activity|upregulation of glutamylhydroxamic synthetase activity True http://purl.obolibrary.org/obo/GO_1905480 GO:2000852 biolink:BiologicalProcess regulation of corticosterone secretion Any process that modulates the frequency, rate or extent of corticosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000852 GO:2000853 biolink:BiologicalProcess negative regulation of corticosterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000853 GO:1905481 biolink:BiologicalProcess obsolete cytoplasmic sequestering of protein involved in mitotic DNA replication checkpoint OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic DNA replication checkpoint. go.json True http://purl.obolibrary.org/obo/GO_1905481 GO:1905482 biolink:BiologicalProcess obsolete cytoplasmic sequestering of protein involved in G2 DNA damage checkpoint OBSOLETE. Any cytoplasmic sequestering of protein that is involved in G2 DNA damage checkpoint. go.json True http://purl.obolibrary.org/obo/GO_1905482 GO:2000854 biolink:BiologicalProcess positive regulation of corticosterone secretion Any process that activates or increases the frequency, rate or extent of corticosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000854 GO:2000855 biolink:BiologicalProcess regulation of mineralocorticoid secretion Any process that modulates the frequency, rate or extent of mineralocorticoid secretion. go.json http://purl.obolibrary.org/obo/GO_2000855 GO:1905483 biolink:BiologicalProcess regulation of motor neuron migration Any process that modulates the frequency, rate or extent of motor neuron migration. go.json http://purl.obolibrary.org/obo/GO_1905483 GO:1905484 biolink:BiologicalProcess negative regulation of motor neuron migration Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration. go.json down regulation of motor neuron migration|down-regulation of motor neuron migration|downregulation of motor neuron migration|inhibition of motor neuron migration http://purl.obolibrary.org/obo/GO_1905484 GO:2000856 biolink:BiologicalProcess negative regulation of mineralocorticoid secretion Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion. go.json http://purl.obolibrary.org/obo/GO_2000856 GO:2000857 biolink:BiologicalProcess positive regulation of mineralocorticoid secretion Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion. go.json http://purl.obolibrary.org/obo/GO_2000857 GO:1905485 biolink:BiologicalProcess positive regulation of motor neuron migration Any process that activates or increases the frequency, rate or extent of motor neuron migration. go.json activation of motor neuron migration|up regulation of motor neuron migration|up-regulation of motor neuron migration|upregulation of motor neuron migration http://purl.obolibrary.org/obo/GO_1905485 GO:1905486 biolink:BiologicalProcess regulation of anterior/posterior axon guidance Any process that modulates the frequency, rate or extent of anterior/posterior axon guidance. go.json regulation of anterior-posterior axon guidance|regulation of anterior/posterior axon pathfinding http://purl.obolibrary.org/obo/GO_1905486 GO:2000858 biolink:BiologicalProcess regulation of aldosterone secretion Any process that modulates the frequency, rate or extent of aldosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000858 GO:1905487 biolink:BiologicalProcess negative regulation of anterior/posterior axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of anterior/posterior axon guidance. go.json down regulation of anterior-posterior axon guidance|down regulation of anterior/posterior axon guidance|down regulation of anterior/posterior axon pathfinding|down-regulation of anterior-posterior axon guidance|down-regulation of anterior/posterior axon guidance|down-regulation of anterior/posterior axon pathfinding|downregulation of anterior-posterior axon guidance|downregulation of anterior/posterior axon guidance|downregulation of anterior/posterior axon pathfinding|inhibition of anterior-posterior axon guidance|inhibition of anterior/posterior axon guidance|inhibition of anterior/posterior axon pathfinding|negative regulation of anterior-posterior axon guidance|negative regulation of anterior/posterior axon pathfinding http://purl.obolibrary.org/obo/GO_1905487 GO:2000859 biolink:BiologicalProcess negative regulation of aldosterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion. go.json http://purl.obolibrary.org/obo/GO_2000859 GO:1905477 biolink:BiologicalProcess positive regulation of protein localization to membrane Any process that activates or increases the frequency, rate or extent of protein localization to membrane. go.json activation of protein localisation in membrane|activation of protein localization in membrane|activation of protein localization to membrane|positive regulation of protein localisation in membrane|positive regulation of protein localization in membrane|up regulation of protein localisation in membrane|up regulation of protein localization in membrane|up regulation of protein localization to membrane|up-regulation of protein localisation in membrane|up-regulation of protein localization in membrane|up-regulation of protein localization to membrane|upregulation of protein localisation in membrane|upregulation of protein localization in membrane|upregulation of protein localization to membrane http://purl.obolibrary.org/obo/GO_1905477 GO:1905478 biolink:BiologicalProcess obsolete regulation of glutamate-ammonia ligase activity OBSOLETE. Any process that modulates the frequency, rate or extent of glutamate-ammonia ligase activity. go.json regulation of L-glutamate:ammonia ligase (ADP-forming)|regulation of L-glutamine synthetase activity|regulation of glutamine synthetase activity|regulation of glutamylhydroxamic synthetase activity True http://purl.obolibrary.org/obo/GO_1905478 GO:1905479 biolink:BiologicalProcess obsolete negative regulation of glutamate-ammonia ligase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glutamate-ammonia ligase activity. go.json down regulation of L-glutamate:ammonia ligase (ADP-forming)|down regulation of L-glutamine synthetase activity|down regulation of glutamate-ammonia ligase activity|down regulation of glutamine synthetase activity|down regulation of glutamylhydroxamic synthetase activity|down-regulation of L-glutamate:ammonia ligase (ADP-forming)|down-regulation of L-glutamine synthetase activity|down-regulation of glutamate-ammonia ligase activity|down-regulation of glutamine synthetase activity|down-regulation of glutamylhydroxamic synthetase activity|downregulation of L-glutamate:ammonia ligase (ADP-forming)|downregulation of L-glutamine synthetase activity|downregulation of glutamate-ammonia ligase activity|downregulation of glutamine synthetase activity|downregulation of glutamylhydroxamic synthetase activity|inhibition of L-glutamate:ammonia ligase (ADP-forming)|inhibition of L-glutamine synthetase activity|inhibition of glutamate-ammonia ligase activity|inhibition of glutamine synthetase activity|inhibition of glutamylhydroxamic synthetase activity|negative regulation of L-glutamate:ammonia ligase (ADP-forming)|negative regulation of L-glutamine synthetase activity|negative regulation of glutamine synthetase activity|negative regulation of glutamylhydroxamic synthetase activity True http://purl.obolibrary.org/obo/GO_1905479 GO:2000850 biolink:BiologicalProcess negative regulation of glucocorticoid secretion Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion. go.json http://purl.obolibrary.org/obo/GO_2000850 GO:2000851 biolink:BiologicalProcess positive regulation of glucocorticoid secretion Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion. go.json http://purl.obolibrary.org/obo/GO_2000851 GO:0075250 biolink:BiologicalProcess negative regulation of aeciospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium. go.json http://purl.obolibrary.org/obo/GO_0075250 GO:0075251 biolink:BiologicalProcess uredospore formation The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus. go.json urediniospore formation|ureidospore formation http://purl.obolibrary.org/obo/GO_0075251 GO:0075252 biolink:BiologicalProcess regulation of uredospore formation Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium. go.json regulation of ureidospore formation http://purl.obolibrary.org/obo/GO_0075252 GO:0075253 biolink:BiologicalProcess positive regulation of uredospore formation Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium. go.json positive regulation of ureidospore formation http://purl.obolibrary.org/obo/GO_0075253 GO:0075254 biolink:BiologicalProcess negative regulation of uredospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium. go.json negative regulation of ureidospore formation http://purl.obolibrary.org/obo/GO_0075254 GO:0075255 biolink:BiologicalProcess teliospore formation The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. go.json http://purl.obolibrary.org/obo/GO_0075255 GO:0075256 biolink:BiologicalProcess regulation of teliospore formation Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. go.json http://purl.obolibrary.org/obo/GO_0075256 GO:0075257 biolink:BiologicalProcess positive regulation of teliospore formation Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. go.json http://purl.obolibrary.org/obo/GO_0075257 GO:0002225 biolink:BiologicalProcess positive regulation of antimicrobial peptide production Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production. go.json activation of antimicrobial peptide production|antimicrobial peptide induction|stimulation of antimicrobial peptide production|up regulation of antimicrobial peptide production|up-regulation of antimicrobial peptide production|upregulation of antimicrobial peptide production http://purl.obolibrary.org/obo/GO_0002225 GO:0002226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002226 GO:0002227 biolink:BiologicalProcess innate immune response in mucosa Any process of the innate immune response that takes place in the mucosal tissues. go.json http://purl.obolibrary.org/obo/GO_0002227 GO:0002228 biolink:BiologicalProcess natural killer cell mediated immunity The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. go.json NK cell mediated immunity http://purl.obolibrary.org/obo/GO_0002228 GO:0002221 biolink:BiologicalProcess pattern recognition receptor signaling pathway The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. go.json PRR signaling pathway|pathogen receptor signaling pathway|pathogen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002221 GO:0002222 biolink:BiologicalProcess stimulatory killer cell immunoglobulin-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a killer cell immunoglobulin-like receptor capable of cellular activation. go.json stimulatory KIR signaling pathway|stimulatory killer cell immunoglobulin-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002222 GO:0002223 biolink:BiologicalProcess stimulatory C-type lectin receptor signaling pathway The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation. go.json stimulatory C-type lectin receptor signalling pathway|stimulatory Ly49 family receptor signaling pathway http://purl.obolibrary.org/obo/GO_0002223 GO:0002224 biolink:BiologicalProcess toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. go.json TLR signaling pathway|toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002224 GO:0002220 biolink:BiologicalProcess innate immune response activating cell surface receptor signaling pathway The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response. go.json activation of innate immune response by cell surface receptor signaling pathway|innate immune response activating cell surface receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002220 GO:0016866 biolink:MolecularActivity intramolecular transferase activity Catalysis of the transfer of a functional group from one position to another within a single molecule. EC:5.4.-.- go.json intramolecular transferase activity, transferring other groups|mutase activity http://purl.obolibrary.org/obo/GO_0016866 GO:0016867 biolink:MolecularActivity intramolecular acyltransferase activity Catalysis of the transfer of an acyl group from one position to another within a single molecule. EC:5.4.1.- go.json intramolecular transferase activity, transferring acyl groups http://purl.obolibrary.org/obo/GO_0016867 GO:0016868 biolink:MolecularActivity intramolecular phosphotransferase activity Catalysis of the transfer of a phosphate group from one position to another within a single molecule. EC:5.4.2.- go.json intramolecular transferase activity, phosphotransferases|phosphomutase activity|phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers http://purl.obolibrary.org/obo/GO_0016868 GO:0016869 biolink:MolecularActivity intramolecular aminotransferase activity Catalysis of the transfer of an amino group from one position to another within a single molecule. EC:5.4.3.- go.json intramolecular transferase activity, transferring amino groups http://purl.obolibrary.org/obo/GO_0016869 GO:0016862 biolink:MolecularActivity intramolecular oxidoreductase activity, interconverting keto- and enol-groups Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. EC:5.3.2.- go.json intramolecular isomerase activity, interconverting keto- and enol-groups http://purl.obolibrary.org/obo/GO_0016862 GO:0016863 biolink:MolecularActivity intramolecular oxidoreductase activity, transposing C=C bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. EC:5.3.3.- go.json intramolecular isomerase activity, transposing C=C bonds http://purl.obolibrary.org/obo/GO_0016863 GO:0016864 biolink:MolecularActivity intramolecular oxidoreductase activity, transposing S-S bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. EC:5.3.4.- go.json intramolecular isomerase activity, transposing S-S bonds http://purl.obolibrary.org/obo/GO_0016864 GO:0016865 biolink:MolecularActivity obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized. go.json intramolecular isomerase activity, other intramolecular oxidoreductases|intramolecular oxidoreductase activity, other intramolecular oxidoreductases True http://purl.obolibrary.org/obo/GO_0016865 GO:0016860 biolink:MolecularActivity intramolecular oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. EC:5.3.-.-|Reactome:R-HSA-109998 go.json intramolecular isomerase activity|intramolecular oxidoreductase activity, other intramolecular oxidoreductases http://purl.obolibrary.org/obo/GO_0016860 GO:0016861 biolink:MolecularActivity intramolecular oxidoreductase activity, interconverting aldoses and ketoses Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. EC:5.3.1.- go.json intramolecular isomerase activity, interconverting aldoses and ketoses http://purl.obolibrary.org/obo/GO_0016861 GO:0002229 biolink:BiologicalProcess defense response to oomycetes Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. go.json http://purl.obolibrary.org/obo/GO_0002229 GO:0002236 biolink:BiologicalProcess detection of misfolded protein The series of events in which a misfolded protein stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0002236 GO:0002237 biolink:BiologicalProcess response to molecule of bacterial origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. go.json response to bacteria associated molecule|response to bacterial associated molecule|response to bacterium associated molecule http://purl.obolibrary.org/obo/GO_0002237 GO:0002238 biolink:BiologicalProcess response to molecule of fungal origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. go.json response to fungus associated molecule http://purl.obolibrary.org/obo/GO_0002238 GO:0002239 biolink:BiologicalProcess response to oomycetes Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes. go.json http://purl.obolibrary.org/obo/GO_0002239 GO:0002232 biolink:BiologicalProcess leukocyte chemotaxis involved in inflammatory response The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. go.json immune cell chemotaxis during inflammatory response|leucocyte chemotaxis during inflammatory response|leukocyte chemotaxis during inflammatory response http://purl.obolibrary.org/obo/GO_0002232 GO:0002233 biolink:BiologicalProcess leukocyte chemotaxis involved in immune response The movement of an immune cell in response to an external stimulus a part of an immune response. go.json immune cell chemotaxis during immune response|leucocyte chemotaxis during immune response http://purl.obolibrary.org/obo/GO_0002233 GO:0002234 biolink:BiologicalProcess detection of endoplasmic reticulum overloading The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal. go.json detection of ER overloading http://purl.obolibrary.org/obo/GO_0002234 GO:0002235 biolink:BiologicalProcess detection of unfolded protein The series of events in which an unfolded protein stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0002235 GO:0002230 biolink:BiologicalProcess positive regulation of defense response to virus by host Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. go.json activation of antiviral response by host|positive regulation of antiviral response by host|stimulation of antiviral response by host|up regulation of antiviral response by host|up-regulation of antiviral response by host|upregulation of antiviral response by host http://purl.obolibrary.org/obo/GO_0002230 GO:0002231 biolink:BiologicalProcess detection of oomycetes The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0002231 GO:0016877 biolink:MolecularActivity ligase activity, forming carbon-sulfur bonds Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.2.-.- go.json ligase activity, forming carbon-sulphur bonds http://purl.obolibrary.org/obo/GO_0016877 GO:0016878 biolink:MolecularActivity acid-thiol ligase activity Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.2.1.- go.json http://purl.obolibrary.org/obo/GO_0016878 GO:0016879 biolink:MolecularActivity ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.3.-.- go.json other carbon-nitrogen ligase activity http://purl.obolibrary.org/obo/GO_0016879 GO:0016873 biolink:MolecularActivity obsolete other isomerase activity OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized. go.json other isomerase activity True http://purl.obolibrary.org/obo/GO_0016873 GO:0016874 biolink:MolecularActivity ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. EC:6.-.-.- go.json synthetase activity http://purl.obolibrary.org/obo/GO_0016874 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_yeast|prokaryote_subset GO:0016875 biolink:MolecularActivity ligase activity, forming carbon-oxygen bonds Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.1.-.- go.json http://purl.obolibrary.org/obo/GO_0016875 GO:0016876 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016876 GO:0016870 biolink:MolecularActivity obsolete intramolecular transferase activity, transferring other groups OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized. go.json intramolecular transferase activity, transferring other groups True http://purl.obolibrary.org/obo/GO_0016870 GO:0016871 biolink:MolecularActivity cycloartenol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. EC:5.4.99.8|KEGG_REACTION:R03200|MetaCyc:CYCLOARTENOL-SYNTHASE-RXN|RHEA:21308 go.json (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)|2,3-epoxysqualene cycloartenol-cyclase activity|2,3-epoxysqualene--cycloartenol cyclase activity|2,3-oxidosqualene-cycloartenol cyclase activity|oxidosqualene:cycloartenol cyclase activity|squalene-2,3-epoxide-cycloartenol cyclase activity http://purl.obolibrary.org/obo/GO_0016871 GO:0016872 biolink:MolecularActivity intramolecular lyase activity The catalysis of certain rearrangements of a molecule to break or form a ring. EC:5.5.1.- go.json http://purl.obolibrary.org/obo/GO_0016872 GO:0002203 biolink:BiologicalProcess proteolysis by cytosolic proteases associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002203 GO:0002204 biolink:BiologicalProcess somatic recombination of immunoglobulin genes involved in immune response The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. go.json somatic recombination of antibody genes during immune response|somatic recombination of immunoglobulin genes during immune response http://purl.obolibrary.org/obo/GO_0002204 GO:0002205 biolink:BiologicalProcess somatic hypermutation of immunoglobulin genes involved in immune response Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response. go.json somatic hypermutation of antibody genes during immune response|somatic hypermutation of immunoglobulin genes during immune response http://purl.obolibrary.org/obo/GO_0002205 GO:0002206 biolink:BiologicalProcess gene conversion of immunoglobulin genes The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion. go.json gene conversion of antibody genes http://purl.obolibrary.org/obo/GO_0002206 GO:0002200 biolink:BiologicalProcess somatic diversification of immune receptors The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. go.json http://purl.obolibrary.org/obo/GO_0002200 GO:0002201 biolink:BiologicalProcess somatic diversification of DSCAM-based immune receptors The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects. go.json http://purl.obolibrary.org/obo/GO_0002201 GO:0002202 biolink:BiologicalProcess somatic diversification of variable lymphocyte receptors of jawless fish The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish. go.json http://purl.obolibrary.org/obo/GO_0002202 GO:0016848 biolink:MolecularActivity carbon-halide lyase activity Catalysis of the breakage of a bond between carbon and any halogen atom. EC:4.5.-.- go.json http://purl.obolibrary.org/obo/GO_0016848 GO:0016849 biolink:MolecularActivity phosphorus-oxygen lyase activity Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. EC:4.6.-.- go.json http://purl.obolibrary.org/obo/GO_0016849 GO:0016844 biolink:MolecularActivity strictosidine synthase activity Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine. EC:4.3.3.2|KEGG_REACTION:R03738|MetaCyc:STRICTOSIDINE-SYNTHASE-RXN|RHEA:15013 go.json 3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)|3-alpha(S)-strictosidine tryptamine-lyase activity|STR activity|strictosidine synthetase activity http://purl.obolibrary.org/obo/GO_0016844 GO:0016845 biolink:MolecularActivity obsolete other carbon-nitrogen lyase activity OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases. go.json other carbon-nitrogen lyase activity True http://purl.obolibrary.org/obo/GO_0016845 GO:0016846 biolink:MolecularActivity carbon-sulfur lyase activity Catalysis of the elimination of hydrogen sulfide or substituted H2S. EC:4.4.-.-|Reactome:R-HSA-1614567 go.json carbon-sulphur lyase activity http://purl.obolibrary.org/obo/GO_0016846 GO:0016847 biolink:MolecularActivity 1-aminocyclopropane-1-carboxylate synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H+. EC:4.4.1.14|KEGG_REACTION:R00179|MetaCyc:4.4.1.14-RXN|RHEA:21744 go.json 1-aminocyclopropane-1-carboxylate synthetase activity|1-aminocyclopropane-1-carboxylic acid synthase activity|1-aminocyclopropanecarboxylate synthase activity|ACC synthase activity|L-VG deaminase activity|L-vinylglycine deaminase activity|S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)|S-adenosyl-L-methionine methylthioadenosine-lyase activity|aminocyclopropanecarboxylate synthase activity|aminocyclopropanecarboxylic acid synthase activity http://purl.obolibrary.org/obo/GO_0016847 GO:0016840 biolink:MolecularActivity carbon-nitrogen lyase activity Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). EC:4.3.-.- go.json other carbon-nitrogen lyase activity http://purl.obolibrary.org/obo/GO_0016840 GO:0016841 biolink:MolecularActivity ammonia-lyase activity Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. EC:4.3.1.- go.json http://purl.obolibrary.org/obo/GO_0016841 GO:0016842 biolink:MolecularActivity amidine-lyase activity Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. EC:4.3.2.- go.json http://purl.obolibrary.org/obo/GO_0016842 GO:0016843 biolink:MolecularActivity amine-lyase activity Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. EC:4.3.3.- go.json http://purl.obolibrary.org/obo/GO_0016843 GO:0002207 biolink:BiologicalProcess gene conversion of immunoglobulin genes involved in immune response The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response. go.json gene conversion of antibody genes during immune response|gene conversion of immunoglobulin genes during immune response http://purl.obolibrary.org/obo/GO_0002207 GO:0002208 biolink:BiologicalProcess somatic diversification of immunoglobulins involved in immune response The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. go.json somatic diversification of antibodies during immune response|somatic diversification of immunoglobulins during immune response http://purl.obolibrary.org/obo/GO_0002208 GO:0002209 biolink:BiologicalProcess behavioral defense response A behavioral response seeking to protect an organism from an a perceived external threat to that organism. go.json behavioural defense response http://purl.obolibrary.org/obo/GO_0002209 GO:0002214 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002214 GO:0002215 biolink:BiologicalProcess defense response to nematode A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. go.json physiological defense response to nematode http://purl.obolibrary.org/obo/GO_0002215 GO:0002216 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002216 GO:0002217 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002217 GO:0002210 biolink:BiologicalProcess behavioral response to wounding A behavioral response resulting from wounding. go.json behavioural response to wounding http://purl.obolibrary.org/obo/GO_0002210 GO:0002211 biolink:BiologicalProcess behavioral defense response to insect A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism. go.json behavioural defense response to insect http://purl.obolibrary.org/obo/GO_0002211 GO:0002212 biolink:BiologicalProcess behavioral defense response to nematode A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism. go.json behavioural defense response to nematode http://purl.obolibrary.org/obo/GO_0002212 GO:0002213 biolink:BiologicalProcess defense response to insect A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. go.json physiological defense response to insect http://purl.obolibrary.org/obo/GO_0002213 GO:0016859 biolink:MolecularActivity cis-trans isomerase activity Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. EC:5.2.-.- go.json http://purl.obolibrary.org/obo/GO_0016859 GO:0016855 biolink:MolecularActivity racemase and epimerase activity, acting on amino acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. EC:5.1.1.- go.json http://purl.obolibrary.org/obo/GO_0016855 GO:0016856 biolink:MolecularActivity racemase and epimerase activity, acting on hydroxy acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule. EC:5.1.2.- go.json http://purl.obolibrary.org/obo/GO_0016856 GO:0016857 biolink:MolecularActivity racemase and epimerase activity, acting on carbohydrates and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. EC:5.1.3.-|Reactome:R-HSA-6787677 go.json http://purl.obolibrary.org/obo/GO_0016857 GO:0016858 biolink:MolecularActivity obsolete racemase and epimerase activity, acting on other compounds OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives. go.json racemase and epimerase activity, acting on other compounds True http://purl.obolibrary.org/obo/GO_0016858 GO:0016851 biolink:MolecularActivity magnesium chelatase activity Catalysis of the reaction: ATP + H2O + Mg2+ + protoporphyrin IX = ADP + 3 H+ + Mg-protoporphyrin IX + phosphate. EC:6.6.1.1|KEGG_REACTION:R03877|MetaCyc:RXN1F-20|RHEA:13961 go.json Mg-chelatase activity|Mg-protoporphyrin IX chelatase activity|Mg-protoporphyrin IX magnesio-lyase activity|Mg-protoporphyrin IX magnesium-lyase activity|magnesium-chelatase activity|magnesium-protoporphyrin IX chelatase activity|magnesium-protoporphyrin chelatase activity|protoporphyrin IX Mg-chelatase activity|protoporphyrin IX magnesium-chelatase activity http://purl.obolibrary.org/obo/GO_0016851 GO:0016852 biolink:MolecularActivity sirohydrochlorin cobaltochelatase activity Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+. EC:4.99.1.3|MetaCyc:4.99.1.3-RXN|RHEA:15893 go.json anaerobic cobalt chelatase activity|cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)|cobaltochelatase|sirohydrochlorin cobalt-lyase activity http://purl.obolibrary.org/obo/GO_0016852 GO:0016853 biolink:MolecularActivity isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. EC:5.-.-.-|Reactome:R-HSA-6787623 go.json other isomerase activity http://purl.obolibrary.org/obo/GO_0016853 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_yeast|prokaryote_subset GO:0016854 biolink:MolecularActivity racemase and epimerase activity Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. EC:5.1.-.- go.json racemase and epimerase activity, acting on other compounds http://purl.obolibrary.org/obo/GO_0016854 GO:0016850 biolink:MolecularActivity obsolete other lyase activity OBSOLETE. A grouping term for lyases that cannot be more accurately categorized. go.json other lyase activity True http://purl.obolibrary.org/obo/GO_0016850 GO:0002218 biolink:BiologicalProcess activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. go.json http://purl.obolibrary.org/obo/GO_0002218 GO:0002219 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002219 GO:0016826 biolink:MolecularActivity hydrolase activity, acting on acid sulfur-nitrogen bonds Catalysis of the hydrolysis of any acid sulfur-nitrogen bond. EC:3.10.-.- go.json hydrolase activity, acting on acid sulphur-nitrogen bonds http://purl.obolibrary.org/obo/GO_0016826 GO:0016827 biolink:MolecularActivity hydrolase activity, acting on acid carbon-phosphorus bonds Catalysis of the hydrolysis of any acid carbon-phosphorus bond. EC:3.11.-.- go.json http://purl.obolibrary.org/obo/GO_0016827 GO:0016828 biolink:MolecularActivity hydrolase activity, acting on acid sulfur-sulfur bonds Catalysis of the hydrolysis of any acid sulfur-sulfur bond. EC:3.12.-.- go.json hydrolase activity, acting on acid sulphur-sulphur bonds http://purl.obolibrary.org/obo/GO_0016828 GO:0016829 biolink:MolecularActivity lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. EC:4.-.-.-|Reactome:R-HSA-5696408|Reactome:R-HSA-6782895 go.json http://purl.obolibrary.org/obo/GO_0016829 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_yeast|prokaryote_subset GO:0016822 biolink:MolecularActivity hydrolase activity, acting on acid carbon-carbon bonds Catalysis of the hydrolysis of any acid carbon-carbon bond. EC:3.7.-.- go.json http://purl.obolibrary.org/obo/GO_0016822 GO:0016823 biolink:MolecularActivity hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. EC:3.7.1.- go.json http://purl.obolibrary.org/obo/GO_0016823 GO:0016824 biolink:MolecularActivity hydrolase activity, acting on acid halide bonds Catalysis of the hydrolysis of any acid halide bond. EC:3.8.-.- go.json http://purl.obolibrary.org/obo/GO_0016824 GO:0016825 biolink:MolecularActivity hydrolase activity, acting on acid phosphorus-nitrogen bonds Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond. EC:3.9.1.- go.json http://purl.obolibrary.org/obo/GO_0016825 GO:0016820 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016820 GO:0016821 biolink:MolecularActivity obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement OBSOLETE. (Was not defined before being made obsolete). go.json hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement True http://purl.obolibrary.org/obo/GO_0016821 GO:0051203 biolink:BiologicalProcess peptidyl-aspartic acid reduction to form L-aspartyl aldehyde The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein. RESID:AA0373 go.json peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde|peptidyl-aspartic acid reduction to form L-beta-formylalanine http://purl.obolibrary.org/obo/GO_0051203 gocheck_do_not_annotate GO:0051204 biolink:BiologicalProcess protein insertion into mitochondrial membrane The process that results in the incorporation of a protein into a mitochondrial membrane. go.json integral mitochondrial membrane protein localization|integral mitochondrial membrane protein positioning|localization of protein in mitochondrial membrane|positioning of protein in mitochondrial membrane|protein insertion into mitochondrion membrane|protein-mitochondrial membrane insertion|protein-mitochondrion membrane insertion http://purl.obolibrary.org/obo/GO_0051204 GO:0051201 biolink:BiologicalProcess obsolete negative regulation of prosthetic group metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. go.json down regulation of prosthetic group metabolic process|down-regulation of prosthetic group metabolic process|downregulation of prosthetic group metabolic process|inhibition of prosthetic group metabolic process|negative regulation of coenzyme and prosthetic group metabolic process|negative regulation of coenzyme and prosthetic group metabolism|negative regulation of prosthetic group metabolism True http://purl.obolibrary.org/obo/GO_0051201 GO:0051202 biolink:BiologicalProcess phytochromobilin metabolic process The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity. go.json phytochromobilin metabolism http://purl.obolibrary.org/obo/GO_0051202 GO:0051207 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051207 GO:0051208 biolink:BiologicalProcess sequestering of calcium ion The process of binding or confining calcium ions such that they are separated from other components of a biological system. go.json calcium ion (Ca2+) retention|calcium ion (Ca2+) sequestering|calcium ion (Ca2+) sequestration|calcium ion (Ca2+) storage|calcium ion storage activity|negative regulation of calcium ion (Ca2+) transport|retention of calcium ion (Ca2+)|sequestering of calcium ion (Ca2+)|sequestration of calcium ion (Ca2+)|storage of calcium ion (Ca2+) http://purl.obolibrary.org/obo/GO_0051208 GO:0051205 biolink:BiologicalProcess protein insertion into membrane The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. go.json integral membrane protein localization|integral membrane protein positioning|membrane protein localization|membrane protein positioning|protein-membrane insertion http://purl.obolibrary.org/obo/GO_0051205 GO:0051206 biolink:BiologicalProcess silicate metabolic process The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. go.json silicate metabolism http://purl.obolibrary.org/obo/GO_0051206 GO:0051209 biolink:BiologicalProcess release of sequestered calcium ion into cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. go.json calcium ion (Ca2+) mobilization|calcium mobilization|cytoplasmic release of sequestered calcium ion (Ca2+)|cytoplasmic release of stored calcium ion (Ca2+)|cytosolic release of sequestered calcium ion (Ca2+)|cytosolic release of stored calcium ion (Ca2+)|release of sequestered calcium ion (Ca2+)|release of sequestered calcium ion into cytoplasm|release of stored calcium ion (Ca2+)|release of stored calcium ion (Ca2+) into cytoplasm|release of stored calcium ion (Ca2+) into cytosol http://purl.obolibrary.org/obo/GO_0051209 GO:0016837 biolink:MolecularActivity carbon-oxygen lyase activity, acting on polysaccharides Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. EC:4.2.2.- go.json http://purl.obolibrary.org/obo/GO_0016837 GO:0016838 biolink:MolecularActivity carbon-oxygen lyase activity, acting on phosphates Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. EC:4.2.3.- go.json http://purl.obolibrary.org/obo/GO_0016838 GO:0016839 biolink:MolecularActivity obsolete other carbon-oxygen lyase activity OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases. go.json other carbon-oxygen lyase activity True http://purl.obolibrary.org/obo/GO_0016839 GO:0016833 biolink:MolecularActivity oxo-acid-lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. EC:4.1.3.- go.json oxo-acid lyase activity|oxoacid lyase activity http://purl.obolibrary.org/obo/GO_0016833 GO:0016834 biolink:MolecularActivity obsolete other carbon-carbon lyase activity OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized. go.json other carbon-carbon lyase activity True http://purl.obolibrary.org/obo/GO_0016834 GO:0016835 biolink:MolecularActivity carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond. EC:4.2.-.- go.json other carbon-oxygen lyase activity http://purl.obolibrary.org/obo/GO_0016835 GO:0016836 biolink:MolecularActivity hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. EC:4.2.1.-|Reactome:R-HSA-9014627 go.json http://purl.obolibrary.org/obo/GO_0016836 GO:0016830 biolink:MolecularActivity carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. EC:4.1.-.-|Reactome:R-HSA-389611 go.json other carbon-carbon lyase activity http://purl.obolibrary.org/obo/GO_0016830 GO:0016831 biolink:MolecularActivity carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. EC:4.1.1.-|Reactome:R-HSA-6787757|Reactome:R-HSA-6814165|Reactome:R-HSA-71223 go.json decarboxylase activity http://purl.obolibrary.org/obo/GO_0016831 GO:0016832 biolink:MolecularActivity aldehyde-lyase activity Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. EC:4.1.2.-|Reactome:R-HSA-200651|Reactome:R-HSA-200735|Reactome:R-HSA-71249 go.json aldolase activity http://purl.obolibrary.org/obo/GO_0016832 GO:0051200 biolink:BiologicalProcess obsolete positive regulation of prosthetic group metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. go.json activation of prosthetic group metabolic process|positive regulation of coenzyme and prosthetic group metabolic process|positive regulation of coenzyme and prosthetic group metabolism|positive regulation of prosthetic group metabolism|stimulation of prosthetic group metabolic process|up regulation of prosthetic group metabolic process|up-regulation of prosthetic group metabolic process|upregulation of prosthetic group metabolic process True http://purl.obolibrary.org/obo/GO_0051200 GO:0051214 biolink:BiologicalProcess RNAi-mediated antiviral immunity against RNA virus An RNAi-mediated post-transcriptional gene silencing pathway induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL4 is the primary Dicer to detect RNA viruses. go.json RNA VIGS|RNA virus induced gene silencing|RNA virus-induced PTGS|RNA virus-induced gene silencing http://purl.obolibrary.org/obo/GO_0051214 GO:0051215 biolink:BiologicalProcess RNAi-mediated antiviral immunity against DNA virus An RNAi-mediated post-transcriptional gene silencing pathway induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL3 is the primary Dicer to detect DNA viruses. go.json DNA VIGS|DNA virus induced gene silencing|DNA virus-induced PTGS|DNA virus-induced gene silencing http://purl.obolibrary.org/obo/GO_0051215 GO:0051212 biolink:MolecularActivity vanadium ion binding Binding to a vanadium ion (V). go.json V ion binding http://purl.obolibrary.org/obo/GO_0051212 GO:0051213 biolink:MolecularActivity dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. Reactome:R-HSA-112120|Reactome:R-HSA-112121|Reactome:R-HSA-112124|Reactome:R-HSA-112125 go.json http://purl.obolibrary.org/obo/GO_0051213 goslim_pir GO:0051218 biolink:BiologicalProcess tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). RESID:AA0376 go.json http://purl.obolibrary.org/obo/GO_0051218 gocheck_do_not_annotate GO:0051219 biolink:MolecularActivity phosphoprotein binding Binding to a phosphorylated protein. go.json phosphorylated protein binding http://purl.obolibrary.org/obo/GO_0051219 goslim_chembl GO:0051216 biolink:BiologicalProcess cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. Wikipedia:Chondrogenesis go.json cartilage biogenesis|cartilage biosynthesis|cartilage element development|cartilage formation|cartilage organ development|chondrogenesis http://purl.obolibrary.org/obo/GO_0051216 GO:0051217 biolink:BiologicalProcess molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). RESID:AA0375 go.json http://purl.obolibrary.org/obo/GO_0051217 gocheck_do_not_annotate GO:0016808 biolink:MolecularActivity obsolete proprotein convertase activity OBSOLETE. Was not defined before being made obsolete. go.json proprotein convertase activity True http://purl.obolibrary.org/obo/GO_0016808 GO:0016809 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016809 GO:0016804 biolink:MolecularActivity obsolete prolyl aminopeptidase activity OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide. go.json Pro-X aminopeptidase activity|cytosol aminopeptidase V|proline aminopeptidase|proline iminopeptidase activity|prolyl aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0016804 GO:0016805 biolink:MolecularActivity dipeptidase activity Catalysis of the hydrolysis of a dipeptide. EC:3.4.13.-|Reactome:R-HSA-266012|Reactome:R-HSA-5433067|Reactome:R-HSA-5693783|Reactome:R-HSA-9026771 go.json cytosolic dipeptidase activity http://purl.obolibrary.org/obo/GO_0016805 GO:0016806 biolink:MolecularActivity obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain. EC:3.4.14.- go.json dipeptidyl-peptidase and tripeptidyl-peptidase activity True http://purl.obolibrary.org/obo/GO_0016806 GO:0016807 biolink:MolecularActivity cysteine-type carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. EC:3.4.18.-|MetaCyc:3.4.18.1-RXN go.json http://purl.obolibrary.org/obo/GO_0016807 GO:0016800 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016800 GO:0016801 biolink:MolecularActivity hydrolase activity, acting on ether bonds Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. EC:3.3.-.- go.json http://purl.obolibrary.org/obo/GO_0016801 GO:0016802 biolink:MolecularActivity trialkylsulfonium hydrolase activity Catalysis of the hydrolysis of a thioether bond, -S-. EC:3.3.1.- go.json thioether hydrolase activity|trialkylsulphonium hydrolase activity http://purl.obolibrary.org/obo/GO_0016802 GO:0016803 biolink:MolecularActivity ether hydrolase activity Catalysis of the hydrolysis of an ether bond, -O-. EC:3.3.2.-|Reactome:R-HSA-8874435 go.json http://purl.obolibrary.org/obo/GO_0016803 GO:0051210 biolink:BiologicalProcess isotropic cell growth The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth. go.json uniform cell growth http://purl.obolibrary.org/obo/GO_0051210 GO:0051211 biolink:BiologicalProcess anisotropic cell growth The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell. go.json non-isotropic cell growth http://purl.obolibrary.org/obo/GO_0051211 GO:0051225 biolink:BiologicalProcess spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. go.json bipolar spindle biosynthesis|bipolar spindle formation|spindle biosynthesis|spindle formation http://purl.obolibrary.org/obo/GO_0051225 GO:0051226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051226 GO:0051223 biolink:BiologicalProcess regulation of protein transport Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0051223 GO:0051224 biolink:BiologicalProcess negative regulation of protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of protein transport|down-regulation of protein transport|downregulation of protein transport|inhibition of protein transport http://purl.obolibrary.org/obo/GO_0051224 GO:0051229 biolink:BiologicalProcess meiotic spindle disassembly The controlled breakdown of the spindle during a meiotic cell cycle. go.json meiotic spindle breakdown|meiotic spindle catabolism|meiotic spindle degradation|spindle breakdown during meiosis|spindle degradation during meiosis|spindle disassembly during meiosis http://purl.obolibrary.org/obo/GO_0051229 GO:0051227 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051227 GO:0051228 biolink:BiologicalProcess mitotic spindle disassembly The controlled breakdown of the spindle during a mitotic cell cycle. go.json mitotic spindle breakdown|mitotic spindle catabolism|mitotic spindle degradation|spindle breakdown during mitosis|spindle degradation during mitosis|spindle disassembly during mitosis http://purl.obolibrary.org/obo/GO_0051228 GO:0016819 biolink:MolecularActivity hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-. EC:3.6.2.- go.json hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides http://purl.obolibrary.org/obo/GO_0016819 GO:0016815 biolink:MolecularActivity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. EC:3.5.5.- go.json http://purl.obolibrary.org/obo/GO_0016815 GO:0016816 biolink:MolecularActivity obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles. go.json hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds True http://purl.obolibrary.org/obo/GO_0016816 GO:0016817 biolink:MolecularActivity hydrolase activity, acting on acid anhydrides Catalysis of the hydrolysis of any acid anhydride. EC:3.6.-.- go.json hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement http://purl.obolibrary.org/obo/GO_0016817 GO:0016818 biolink:MolecularActivity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. EC:3.6.1.-|Reactome:R-HSA-9731590|Reactome:R-HSA-9731613|Reactome:R-HSA-9731632 go.json http://purl.obolibrary.org/obo/GO_0016818 GO:0016811 biolink:MolecularActivity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. EC:3.5.1.-|Reactome:R-HSA-9673053|Reactome:R-HSA-9673054 go.json http://purl.obolibrary.org/obo/GO_0016811 GO:0016812 biolink:MolecularActivity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. EC:3.5.2.-|Reactome:R-HSA-70906 go.json http://purl.obolibrary.org/obo/GO_0016812 GO:0016813 biolink:MolecularActivity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. EC:3.5.3.- go.json http://purl.obolibrary.org/obo/GO_0016813 GO:0016814 biolink:MolecularActivity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. EC:3.5.4.- go.json http://purl.obolibrary.org/obo/GO_0016814 GO:0016810 biolink:MolecularActivity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. EC:3.5.-.-|Reactome:R-HSA-6803753 go.json hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds http://purl.obolibrary.org/obo/GO_0016810 goslim_chembl|goslim_drosophila GO:0051221 biolink:BiologicalProcess tungsten incorporation into metallo-sulfur cluster The incorporation of tungsten into a metallo-sulfur cluster. go.json tungsten incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0051221 gocheck_do_not_annotate GO:0051222 biolink:BiologicalProcess positive regulation of protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of protein transport|stimulation of protein transport|up regulation of protein transport|up-regulation of protein transport|upregulation of protein transport http://purl.obolibrary.org/obo/GO_0051222 GO:0051220 biolink:BiologicalProcess cytoplasmic sequestering of protein The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. go.json cytoplasmic retention of protein|cytoplasmic sequestration of protein|cytoplasmic storage of protein|maintenance of protein location in cytoplasm|retention of protein in cytoplasm|sequestering of protein in cytoplasm|sequestration of protein in cytoplasm|storage of protein in cytoplasm http://purl.obolibrary.org/obo/GO_0051220 GO:0002287 biolink:BiologicalProcess alpha-beta T cell activation involved in immune response The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. go.json alpha-beta T cell activation during immune response|alpha-beta T lymphocyte activation during immune response|alpha-beta T-cell activation during immune response|alpha-beta T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002287 GO:0002288 biolink:BiologicalProcess NK T cell activation involved in immune response The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. go.json NK T cell activation during immune response|NK T lymphocyte activation during immune response|NK T-cell activation during immune response|NK T-lymphocyte activation during immune response|natural killer T lymphocyte activation during immune response|natural killer T-cell activation during immune response|natural killer T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002288 GO:0002289 biolink:BiologicalProcess NK T cell proliferation involved in immune response The expansion of a NK T cell population by cell division as part of an immune response. go.json NK T cell proliferation during immune response|NK T lymphocyte proliferation during immune response|NK T-cell proliferation during immune response|NK T-lymphocyte proliferation during immune response|natural killer T lymphocyte proliferation during immune response|natural killer T-cell proliferation during immune response|natural killer T-lymphocyte proliferation during immune response http://purl.obolibrary.org/obo/GO_0002289 GO:0002283 biolink:BiologicalProcess neutrophil activation involved in immune response The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json neutrophil activation during immune response http://purl.obolibrary.org/obo/GO_0002283 GO:0002284 biolink:BiologicalProcess myeloid dendritic cell differentiation involved in immune response The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response. go.json myeloid dendritic cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0002284 GO:0002285 biolink:BiologicalProcess lymphocyte activation involved in immune response A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002285 GO:0002286 biolink:BiologicalProcess T cell activation involved in immune response The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. go.json T cell activation during immune response|T lymphocyte activation during immune response|T-cell activation during immune response|T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002286 GO:0099191 biolink:BiologicalProcess trans-synaptic signaling by BDNF Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft. go.json trans-synaptic signaling by brain-derived neurotrophic factor http://purl.obolibrary.org/obo/GO_0099191 goslim_synapse GO:0099192 biolink:CellularComponent cerebellar Golgi cell to granule cell synapse A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell. go.json http://purl.obolibrary.org/obo/GO_0099192 goslim_synapse GO:0002280 biolink:BiologicalProcess monocyte activation involved in immune response The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json monocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002280 GO:0002281 biolink:BiologicalProcess macrophage activation involved in immune response A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json macrophage activation during immune response|macrophage polarization involved in immune response http://purl.obolibrary.org/obo/GO_0002281 GO:0099190 biolink:BiologicalProcess postsynaptic spectrin-associated cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0099190 goslim_synapse GO:0002282 biolink:BiologicalProcess microglial cell activation involved in immune response The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json microglial cell activation during immune response http://purl.obolibrary.org/obo/GO_0002282 GO:0002298 biolink:BiologicalProcess CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response. go.json CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0002298 GO:0002299 biolink:BiologicalProcess alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. go.json alpha-beta intraepithelial T cell development|alpha-beta intraepithelial T lymphocyte differentiation|alpha-beta intraepithelial T-cell differentiation|alpha-beta intraepithelial T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002299 GO:0002294 biolink:BiologicalProcess CD4-positive, alpha-beta T cell differentiation involved in immune response The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. go.json CD4-positive, alpha-beta T cell development involved in immune response|CD4-positive, alpha-beta T cell differentiation during immune response|CD4-positive, alpha-beta T lymphocyte differentiation during immune response|CD4-positive, alpha-beta T-cell differentiation during immune response|CD4-positive, alpha-beta T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0002294 GO:0002295 biolink:BiologicalProcess T-helper cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes. go.json T-helper cell fate commitment|Th0 lineage commitment|Thp lineage commitment http://purl.obolibrary.org/obo/GO_0002295 GO:0002296 biolink:BiologicalProcess T-helper 1 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis. go.json T-helper 1 cell fate commitment|Th1 cell lineage commitment|Th1 fate commitment http://purl.obolibrary.org/obo/GO_0002296 GO:0002297 biolink:BiologicalProcess T-helper 2 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy. go.json T-helper 2 cell fate commitment|Th2 fate commitment http://purl.obolibrary.org/obo/GO_0002297 GO:0002290 biolink:BiologicalProcess gamma-delta T cell activation involved in immune response The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. go.json gamma-delta T cell activation during immune response|gamma-delta T lymphocyte activation during immune response|gamma-delta T-cell activation during immune response|gamma-delta T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002290 GO:0002291 biolink:BiologicalProcess T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. go.json T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell http://purl.obolibrary.org/obo/GO_0002291 GO:0002292 biolink:BiologicalProcess T cell differentiation involved in immune response The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. go.json T cell development involved in immune response|T cell differentiation during immune response|T lymphocyte differentiation during immune response|T-cell differentiation during immune response|T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0002292 GO:0002293 biolink:BiologicalProcess alpha-beta T cell differentiation involved in immune response The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. go.json alpha-beta T cell development involved in immune response|alpha-beta T cell differentiation during immune response|alpha-beta T lymphocyte differentiation during immune response|alpha-beta T-cell differentiation during immune response|alpha-beta T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0002293 GO:0002269 biolink:BiologicalProcess leukocyte activation involved in inflammatory response A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. go.json immune cell activation during inflammatory response|leukocyte activation during inflammatory response http://purl.obolibrary.org/obo/GO_0002269 GO:0002265 biolink:BiologicalProcess astrocyte activation involved in immune response A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json astrocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002265 GO:0002266 biolink:BiologicalProcess follicular dendritic cell activation A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. go.json http://purl.obolibrary.org/obo/GO_0002266 GO:0002267 biolink:BiologicalProcess follicular dendritic cell activation involved in immune response A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json follicular dendritic cell activation during immune response http://purl.obolibrary.org/obo/GO_0002267 GO:0002268 biolink:BiologicalProcess follicular dendritic cell differentiation The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell. go.json http://purl.obolibrary.org/obo/GO_0002268 GO:0002261 biolink:BiologicalProcess mucosal lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0002261 GO:0002262 biolink:BiologicalProcess myeloid cell homeostasis The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0002262 GO:0002263 biolink:BiologicalProcess cell activation involved in immune response A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json cell activation during immune response http://purl.obolibrary.org/obo/GO_0002263 GO:0002264 biolink:BiologicalProcess endothelial cell activation involved in immune response A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json endothelial cell activation during immune response http://purl.obolibrary.org/obo/GO_0002264 GO:0002260 biolink:BiologicalProcess lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0002260 GO:0002276 biolink:BiologicalProcess basophil activation involved in immune response A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. go.json basophil activation during immune response http://purl.obolibrary.org/obo/GO_0002276 GO:0002277 biolink:BiologicalProcess myeloid dendritic cell activation involved in immune response The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json myeloid dendritic cell activation during immune response http://purl.obolibrary.org/obo/GO_0002277 GO:0002278 biolink:BiologicalProcess eosinophil activation involved in immune response The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json eosinophil activation during immune response http://purl.obolibrary.org/obo/GO_0002278 GO:0002279 biolink:BiologicalProcess mast cell activation involved in immune response The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. go.json mast cell activation during immune response http://purl.obolibrary.org/obo/GO_0002279 GO:0002272 biolink:BiologicalProcess plasmacytoid dendritic cell differentiation involved in immune response The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response. go.json plasmacytoid dendritic cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0002272 GO:0002273 biolink:BiologicalProcess plasmacytoid dendritic cell differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell. go.json http://purl.obolibrary.org/obo/GO_0002273 GO:0002274 biolink:BiologicalProcess myeloid leukocyte activation A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. go.json myeloid leucocyte activation http://purl.obolibrary.org/obo/GO_0002274 GO:0002275 biolink:BiologicalProcess myeloid cell activation involved in immune response A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json myeloid cell activation during immune response http://purl.obolibrary.org/obo/GO_0002275 GO:0002270 biolink:BiologicalProcess plasmacytoid dendritic cell activation A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. go.json http://purl.obolibrary.org/obo/GO_0002270 GO:0002271 biolink:BiologicalProcess plasmacytoid dendritic cell activation involved in immune response A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json plasmacytoid dendritic cell activation during immune response http://purl.obolibrary.org/obo/GO_0002271 GO:0002247 biolink:BiologicalProcess clearance of damaged tissue involved in inflammatory response wound healing The series of events leading to removal of necrotic debris that contribute to an inflammatory response. go.json clearance of damaged tissue during inflammatory response http://purl.obolibrary.org/obo/GO_0002247 GO:0002248 biolink:BiologicalProcess connective tissue replacement involved in inflammatory response wound healing The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared, as part of an inflammatory response. go.json connective tissue replacement during inflammatory response|fibrosis during inflammatory response|tissue fibrosis development http://purl.obolibrary.org/obo/GO_0002248 GO:0002249 biolink:BiologicalProcess lymphocyte anergy Any process contributing to lymphocyte anergy, a state of functional inactivation. go.json http://purl.obolibrary.org/obo/GO_0002249 GO:0002243 biolink:BiologicalProcess detection of parasitic plant The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0002243 GO:0002244 biolink:BiologicalProcess hematopoietic progenitor cell differentiation The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. go.json haematopoietic progenitor cell differentiation|haemopoietic progenitor cell differentiation|hemopoietic progenitor cell differentiation http://purl.obolibrary.org/obo/GO_0002244 GO:0002245 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002245 GO:0002246 biolink:BiologicalProcess wound healing involved in inflammatory response The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. go.json healing during inflammatory response|inflammatory response wound healing http://purl.obolibrary.org/obo/GO_0002246 GO:0002240 biolink:BiologicalProcess response to molecule of oomycetes origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. go.json response to oomycetes associated molecule http://purl.obolibrary.org/obo/GO_0002240 GO:0002241 biolink:BiologicalProcess response to parasitic plant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant. go.json http://purl.obolibrary.org/obo/GO_0002241 GO:0002242 biolink:BiologicalProcess defense response to parasitic plant Reactions triggered in response to the presence of a parasitic plant that act to protect an organism. go.json http://purl.obolibrary.org/obo/GO_0002242 GO:0016888 biolink:MolecularActivity endodeoxyribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. EC:3.1.21.-|Reactome:R-HSA-912368 go.json endodeoxyribonuclease activity, producing 5' phosphomonoesters http://purl.obolibrary.org/obo/GO_0016888 GO:0016889 biolink:MolecularActivity DNA endonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. EC:3.1.22.- go.json endodeoxyribonuclease activity, producing 3'-phosphomonoesters|endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016889 GO:0016884 biolink:MolecularActivity carbon-nitrogen ligase activity, with glutamine as amido-N-donor Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen. EC:6.3.5.- go.json http://purl.obolibrary.org/obo/GO_0016884 GO:0016885 biolink:MolecularActivity ligase activity, forming carbon-carbon bonds Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.4.-.- go.json http://purl.obolibrary.org/obo/GO_0016885 GO:0016886 biolink:MolecularActivity ligase activity, forming phosphoric ester bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.5.-.- go.json http://purl.obolibrary.org/obo/GO_0016886 GO:0016887 biolink:MolecularActivity ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. RHEA:13065|Reactome:R-HSA-159101|Reactome:R-HSA-3371422|Reactome:R-HSA-416985|Reactome:R-HSA-5618093|Reactome:R-HSA-5654989|Reactome:R-HSA-5694425|Reactome:R-HSA-6809015|Reactome:R-HSA-6811422|Reactome:R-HSA-6814670|Reactome:R-HSA-6814678|Reactome:R-HSA-6814683|Reactome:R-HSA-8847638|Reactome:R-HSA-8868658|Reactome:R-HSA-8939203|Reactome:R-HSA-9038161|Reactome:R-HSA-917693|Reactome:R-HSA-9609860|Reactome:R-HSA-9668415|Reactome:R-HSA-9706399|Reactome:R-HSA-9749350 go.json ATP hydrolase activity|ATP monophosphatase activity|ATP phosphohydrolase activity|adenosine 5'-triphosphatase activity|adenosine triphosphatase activity|adenosinetriphosphatase activity http://purl.obolibrary.org/obo/GO_0016887 GO:0016880 biolink:MolecularActivity acid-ammonia (or amide) ligase activity Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.3.1.- go.json amide synthase activity http://purl.obolibrary.org/obo/GO_0016880 GO:0016881 biolink:MolecularActivity acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.3.2.- go.json peptide synthase activity http://purl.obolibrary.org/obo/GO_0016881 GO:0016882 biolink:MolecularActivity cyclo-ligase activity Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. EC:6.3.3.- go.json http://purl.obolibrary.org/obo/GO_0016882 GO:0016883 biolink:MolecularActivity obsolete other carbon-nitrogen ligase activity OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized. go.json other carbon-nitrogen ligase activity True http://purl.obolibrary.org/obo/GO_0016883 GO:0002258 biolink:BiologicalProcess positive regulation of kinin cascade Any process that activates or increases the frequency, rate, or extent of the kinin cascade. go.json activation of kinin cascade|stimulation of kinin cascade|up regulation of kinin cascade|up-regulation of kinin cascade|upregulation of kinin cascade http://purl.obolibrary.org/obo/GO_0002258 GO:0002259 biolink:BiologicalProcess endothelial cell activation within high endothelial venule involved in immune response A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. go.json endothelial cell activation within high endothelial venule during immune response http://purl.obolibrary.org/obo/GO_0002259 GO:0002254 biolink:BiologicalProcess kinin cascade A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. go.json http://purl.obolibrary.org/obo/GO_0002254 GO:0002255 biolink:BiologicalProcess tissue kallikrein-kinin cascade A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. go.json glandular kallikrein-kinin cascade http://purl.obolibrary.org/obo/GO_0002255 GO:0002256 biolink:BiologicalProcess regulation of kinin cascade Any process that modulates the frequency, rate, or extent of the kinin cascade. go.json http://purl.obolibrary.org/obo/GO_0002256 GO:0002257 biolink:BiologicalProcess negative regulation of kinin cascade Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade. go.json down regulation of kinin cascade|down-regulation of kinin cascade|downregulation of kinin cascade|inhibition of kinin cascade http://purl.obolibrary.org/obo/GO_0002257 GO:0002250 biolink:BiologicalProcess adaptive immune response An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). Wikipedia:Adaptive_immune_system go.json acquired immune response|immune memory response http://purl.obolibrary.org/obo/GO_0002250 GO:0002251 biolink:BiologicalProcess organ or tissue specific immune response An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. go.json immune response in organ or tissue http://purl.obolibrary.org/obo/GO_0002251 GO:0002252 biolink:BiologicalProcess immune effector process Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. go.json http://purl.obolibrary.org/obo/GO_0002252 GO:0002253 biolink:BiologicalProcess activation of immune response Any process that initiates an immune response. go.json http://purl.obolibrary.org/obo/GO_0002253 GO:0016899 biolink:MolecularActivity oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. EC:1.1.3.- go.json http://purl.obolibrary.org/obo/GO_0016899 GO:0016895 biolink:MolecularActivity DNA exonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. EC:3.1.11.- go.json exodeoxyribonuclease activity, producing 5' phosphomonoesters|exonuclease VIII activity http://purl.obolibrary.org/obo/GO_0016895 GO:0016896 biolink:MolecularActivity RNA exonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. EC:3.1.13.-|Reactome:R-HSA-429860 go.json exoribonuclease activity, producing 5' phosphomonoesters|exoribonuclease activity, producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016896 GO:0016897 biolink:MolecularActivity RNA exonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. EC:3.1.14.- go.json exoribonuclease activity, producing 3'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016897 GO:0016898 biolink:MolecularActivity oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. EC:1.1.2.- go.json http://purl.obolibrary.org/obo/GO_0016898 GO:0016891 biolink:MolecularActivity RNA endonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. EC:3.1.26.- go.json endoribonuclease activity, producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016891 GO:0016892 biolink:MolecularActivity RNA endonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. EC:3.1.27.-|Reactome:R-HSA-9705961|Reactome:R-HSA-9755252 go.json endoribonuclease activity, producing 3'-phosphomonoesters|endoribonuclease activity, producing other than 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016892 GO:0016893 biolink:MolecularActivity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. EC:3.1.30.- go.json 5'-endonuclease activity|endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016893 GO:0016894 biolink:MolecularActivity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. EC:3.1.31.1 go.json 3'-endonuclease activity|endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016894 OIO:SubsetProperty biolink:OntologyClass subset_property go.json http://www.geneontology.org/formats/oboInOwl#SubsetProperty GO:0016890 biolink:MolecularActivity site-specific endodeoxyribonuclease activity, specific for altered base Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. EC:3.1.25.- go.json http://purl.obolibrary.org/obo/GO_0016890 GO:0075324 biolink:BiologicalProcess negative regulation of oomycete sporangium development Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated. go.json http://purl.obolibrary.org/obo/GO_0075324 GO:0051357 biolink:BiologicalProcess obsolete peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one OBSOLETE. The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. RESID:AA0377 go.json biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine|biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine True http://purl.obolibrary.org/obo/GO_0051357 GO:0075325 biolink:BiologicalProcess spore dispersal Any process in which an organism disseminates its spores. go.json active spore dispersal on or near host|active spore dispersal on or near host during symbiotic interaction|passive spore dispersal on or near host|spore dispersal on or near host|spore dispersal on or near host during symbiotic interaction http://purl.obolibrary.org/obo/GO_0075325 GO:0051358 biolink:BiologicalProcess obsolete peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine OBSOLETE. The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus. RESID:AA0378 go.json biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0051358 GO:0051355 biolink:BiologicalProcess proprioception involved in equilibrioception The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity. go.json equilibrioception by proprioception|perception of orientation with respect to gravity by proprioception|proprioception during equilibrioception http://purl.obolibrary.org/obo/GO_0051355 GO:0075326 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075326 GO:0051356 biolink:BiologicalProcess visual perception involved in equilibrioception The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity. go.json equilibrioception by visual perception|perception of orientation with respect to gravity by visual perception|visual perception during equilibrioception http://purl.obolibrary.org/obo/GO_0051356 GO:0075327 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0075327 GO:0075328 biolink:BiologicalProcess formation of arbuscule for nutrient acquisition The assembly of an arbuscule, a fine, tree-like hyphal symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by symbiont of arbuscule for nutrient acquisition from host http://purl.obolibrary.org/obo/GO_0075328 GO:0075329 biolink:BiologicalProcess regulation of arbuscule formation for nutrient acquisition from host Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075329 GO:0051359 biolink:BiologicalProcess obsolete peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine OBSOLETE. The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor. RESID:AA0379 go.json biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0051359 GO:2000742 biolink:BiologicalProcess regulation of anterior head development Any process that modulates the frequency, rate or extent of anterior head development. go.json http://purl.obolibrary.org/obo/GO_2000742 GO:2000743 biolink:BiologicalProcess negative regulation of anterior head development Any process that stops, prevents or reduces the frequency, rate or extent of anterior head development. go.json http://purl.obolibrary.org/obo/GO_2000743 GO:2000744 biolink:BiologicalProcess positive regulation of anterior head development Any process that activates or increases the frequency, rate or extent of anterior head development. go.json http://purl.obolibrary.org/obo/GO_2000744 GO:2000745 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation OBSOLETE. Any positive regulation of transcription from RNA polymerase III promoter that is involved in smooth muscle cell differentiation. go.json activation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation|activation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation|positive regulation of transcription from Pol III promoter of nonstriated muscle cell differentiation|positive regulation of transcription from Pol III promoter of smooth muscle cell differentiation|positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation|positive regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation|positive regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation|stimulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation|stimulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation|up regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation|up regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation|up-regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation|up-regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation|upregulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation|upregulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation True http://purl.obolibrary.org/obo/GO_2000745 GO:2000746 biolink:BiologicalProcess regulation of defecation rhythm Any process that modulates the frequency, rate or extent of defecation rhythm. go.json regulation of DMP|regulation of defecation behavior|regulation of defecation cycle|regulation of defecation motor program http://purl.obolibrary.org/obo/GO_2000746 GO:1905770 biolink:BiologicalProcess regulation of mesodermal cell differentiation Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. go.json regulation of mesoderm cell differentiation http://purl.obolibrary.org/obo/GO_1905770 GO:1905771 biolink:BiologicalProcess negative regulation of mesodermal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. go.json down regulation of mesoderm cell differentiation|down regulation of mesodermal cell differentiation|down-regulation of mesoderm cell differentiation|down-regulation of mesodermal cell differentiation|downregulation of mesoderm cell differentiation|downregulation of mesodermal cell differentiation|inhibition of mesoderm cell differentiation|inhibition of mesodermal cell differentiation|negative regulation of mesoderm cell differentiation http://purl.obolibrary.org/obo/GO_1905771 GO:2000747 biolink:BiologicalProcess negative regulation of defecation rhythm Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm. go.json negative regulation of DMP|negative regulation of defecation behavior|negative regulation of defecation cycle|negative regulation of defecation motor program http://purl.obolibrary.org/obo/GO_2000747 GO:1905772 biolink:BiologicalProcess positive regulation of mesodermal cell differentiation Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. go.json activation of mesoderm cell differentiation|activation of mesodermal cell differentiation|positive regulation of mesoderm cell differentiation|up regulation of mesoderm cell differentiation|up regulation of mesodermal cell differentiation|up-regulation of mesoderm cell differentiation|up-regulation of mesodermal cell differentiation|upregulation of mesoderm cell differentiation|upregulation of mesodermal cell differentiation http://purl.obolibrary.org/obo/GO_1905772 GO:2000748 biolink:BiologicalProcess positive regulation of defecation rhythm Any process that activates or increases the frequency, rate or extent of defecation rhythm. go.json positive regulation of DMP|positive regulation of defecation behavior|positive regulation of defecation cycle|positive regulation of defecation motor program http://purl.obolibrary.org/obo/GO_2000748 GO:2000749 biolink:BiologicalProcess positive regulation of rDNA heterochromatin formation Any process that activates or increases the frequency, rate or extent of rDNA heterochromatin formation. go.json positive regulation of chromatin silencing at rDNA|positive regulation of chromatin silencing at ribosomal DNA|positive regulation of heterochromatic silencing at rDNA|positive regulation of rDNA chromatin silencing|positive regulation of rDNA heterochromatin assembly|positive regulation of ribosomal DNA heterochromatin assembly http://purl.obolibrary.org/obo/GO_2000749 GO:1905773 biolink:MolecularActivity 8-hydroxy-2'-deoxyguanosine DNA binding Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA. go.json http://purl.obolibrary.org/obo/GO_1905773 GO:1905763 biolink:MolecularActivity MTREC complex binding Binding to a MTREC complex. go.json Mtl1-Red1 core complex binding|NURS complex binding|PAXT complex binding http://purl.obolibrary.org/obo/GO_1905763 GO:1905764 biolink:BiologicalProcess regulation of protection from non-homologous end joining at telomere Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere. go.json regulation of protection from NHEJ-mediated telomere fusion http://purl.obolibrary.org/obo/GO_1905764 GO:1905765 biolink:BiologicalProcess negative regulation of protection from non-homologous end joining at telomere Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere. go.json down regulation of protection from NHEJ-mediated telomere fusion|down regulation of protection from non-homologous end joining at telomere|down-regulation of protection from NHEJ-mediated telomere fusion|down-regulation of protection from non-homologous end joining at telomere|downregulation of protection from NHEJ-mediated telomere fusion|downregulation of protection from non-homologous end joining at telomere|inhibition of protection from NHEJ-mediated telomere fusion|inhibition of protection from non-homologous end joining at telomere|negative regulation of protection from NHEJ-mediated telomere fusion http://purl.obolibrary.org/obo/GO_1905765 GO:1905766 biolink:BiologicalProcess positive regulation of protection from non-homologous end joining at telomere Any process that activates or increases the frequency, rate or extent of protection from non-homologous end joining at telomere. go.json activation of protection from NHEJ-mediated telomere fusion|activation of protection from non-homologous end joining at telomere|positive regulation of protection from NHEJ-mediated telomere fusion|up regulation of protection from NHEJ-mediated telomere fusion|up regulation of protection from non-homologous end joining at telomere|up-regulation of protection from NHEJ-mediated telomere fusion|up-regulation of protection from non-homologous end joining at telomere|upregulation of protection from NHEJ-mediated telomere fusion|upregulation of protection from non-homologous end joining at telomere http://purl.obolibrary.org/obo/GO_1905766 GO:1905767 biolink:BiologicalProcess regulation of double-stranded telomeric DNA binding Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding. go.json http://purl.obolibrary.org/obo/GO_1905767 gocheck_do_not_annotate GO:1905768 biolink:BiologicalProcess negative regulation of double-stranded telomeric DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding. go.json down regulation of double-stranded telomeric DNA binding|down-regulation of double-stranded telomeric DNA binding|downregulation of double-stranded telomeric DNA binding|inhibition of double-stranded telomeric DNA binding http://purl.obolibrary.org/obo/GO_1905768 gocheck_do_not_annotate GO:1905769 biolink:BiologicalProcess positive regulation of double-stranded telomeric DNA binding Any process that activates or increases the frequency, rate or extent of double-stranded telomeric DNA binding. go.json activation of double-stranded telomeric DNA binding|up regulation of double-stranded telomeric DNA binding|up-regulation of double-stranded telomeric DNA binding|upregulation of double-stranded telomeric DNA binding http://purl.obolibrary.org/obo/GO_1905769 gocheck_do_not_annotate GO:2000740 biolink:BiologicalProcess negative regulation of mesenchymal stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000740 GO:2000741 biolink:BiologicalProcess positive regulation of mesenchymal stem cell differentiation Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000741 GO:0051350 biolink:BiologicalProcess negative regulation of lyase activity Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. go.json down regulation of lyase activity|down-regulation of lyase activity|downregulation of lyase activity|inhibition of lyase activity|lyase inhibitor http://purl.obolibrary.org/obo/GO_0051350 gocheck_do_not_annotate IAO:0000115 biolink:OntologyClass definition go.json http://purl.obolibrary.org/obo/IAO_0000115 GO:0051353 biolink:BiologicalProcess positive regulation of oxidoreductase activity Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. go.json activation of oxidoreductase activity|oxidoreductase activator|ribonucleotide reductase activating enzyme activity|stimulation of oxidoreductase activity|up regulation of oxidoreductase activity|up-regulation of oxidoreductase activity|upregulation of oxidoreductase activity http://purl.obolibrary.org/obo/GO_0051353 gocheck_do_not_annotate GO:0075320 biolink:BiologicalProcess negative regulation of ascus development Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. go.json http://purl.obolibrary.org/obo/GO_0075320 GO:0051354 biolink:BiologicalProcess negative regulation of oxidoreductase activity Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. go.json down regulation of oxidoreductase activity|down-regulation of oxidoreductase activity|downregulation of oxidoreductase activity|inhibition of oxidoreductase activity|oxidoreductase inhibitor http://purl.obolibrary.org/obo/GO_0051354 gocheck_do_not_annotate GO:0075321 biolink:BiologicalProcess oomycete sporangium development The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated. go.json http://purl.obolibrary.org/obo/GO_0075321 GO:0051351 biolink:BiologicalProcess positive regulation of ligase activity Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. go.json activation of ligase activity|ligase activator|stimulation of ligase activity|up regulation of ligase activity|up-regulation of ligase activity|upregulation of ligase activity http://purl.obolibrary.org/obo/GO_0051351 gocheck_do_not_annotate GO:0075322 biolink:BiologicalProcess regulation of oomycete sporangium development Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated. go.json http://purl.obolibrary.org/obo/GO_0075322 GO:0051352 biolink:BiologicalProcess negative regulation of ligase activity Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. go.json down regulation of ligase activity|down-regulation of ligase activity|downregulation of ligase activity|inhibition of ligase activity|ligase inhibitor http://purl.obolibrary.org/obo/GO_0051352 gocheck_do_not_annotate GO:0075323 biolink:BiologicalProcess positive regulation of oomycete sporangium development Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated. go.json http://purl.obolibrary.org/obo/GO_0075323 GO:0051368 biolink:BiologicalProcess peptidyl-threonine octanoylation The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin. RESID:AA0386 go.json http://purl.obolibrary.org/obo/GO_0051368 gocheck_do_not_annotate GO:0075313 biolink:BiologicalProcess basidium development The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi. go.json http://purl.obolibrary.org/obo/GO_0075313 GO:0051369 biolink:BiologicalProcess peptidyl-threonine decanoylation The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin. RESID:AA0387 go.json http://purl.obolibrary.org/obo/GO_0051369 gocheck_do_not_annotate GO:0075314 biolink:BiologicalProcess regulation of basidium development Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi. go.json http://purl.obolibrary.org/obo/GO_0075314 GO:0075315 biolink:BiologicalProcess positive regulation of basidium development Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi. go.json http://purl.obolibrary.org/obo/GO_0075315 GO:0051366 biolink:BiologicalProcess protein decanoylation The modification of a protein amino acid by formation of an ester or amide with decanoic acid. go.json protein amino acid decanoylation http://purl.obolibrary.org/obo/GO_0051366 gocheck_do_not_annotate GO:0051367 biolink:BiologicalProcess peptidyl-serine decanoylation The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin. RESID:AA0385 go.json http://purl.obolibrary.org/obo/GO_0051367 gocheck_do_not_annotate GO:0075316 biolink:BiologicalProcess negative regulation of basidium development Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi. go.json http://purl.obolibrary.org/obo/GO_0075316 GO:0075317 biolink:BiologicalProcess ascus development The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. go.json http://purl.obolibrary.org/obo/GO_0075317 GO:0075318 biolink:BiologicalProcess regulation of ascus development Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. go.json http://purl.obolibrary.org/obo/GO_0075318 GO:0075319 biolink:BiologicalProcess positive regulation of ascus development Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. go.json http://purl.obolibrary.org/obo/GO_0075319 GO:2000753 biolink:BiologicalProcess positive regulation of glucosylceramide catabolic process Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process. go.json positive regulation of glucosylceramide breakdown|positive regulation of glucosylceramide catabolism|positive regulation of glucosylceramide degradation http://purl.obolibrary.org/obo/GO_2000753 GO:2000754 biolink:BiologicalProcess regulation of sphingomyelin catabolic process Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process. go.json regulation of sphingomyelin breakdown|regulation of sphingomyelin catabolism|regulation of sphingomyelin degradation http://purl.obolibrary.org/obo/GO_2000754 GO:2000755 biolink:BiologicalProcess positive regulation of sphingomyelin catabolic process Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process. go.json positive regulation of sphingomyelin breakdown|positive regulation of sphingomyelin catabolism|positive regulation of sphingomyelin degradation http://purl.obolibrary.org/obo/GO_2000755 GO:2000756 biolink:BiologicalProcess regulation of peptidyl-lysine acetylation Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation. go.json http://purl.obolibrary.org/obo/GO_2000756 GO:1905780 biolink:BiologicalProcess regulation of phosphatidylserine exposure on apoptotic cell surface Any process that modulates the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. go.json regulation of externalization of phosphatidylserine http://purl.obolibrary.org/obo/GO_1905780 GO:1905781 biolink:BiologicalProcess negative regulation of phosphatidylserine exposure on apoptotic cell surface Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. go.json down regulation of externalization of phosphatidylserine|down regulation of phosphatidylserine exposure on apoptotic cell surface|down-regulation of externalization of phosphatidylserine|down-regulation of phosphatidylserine exposure on apoptotic cell surface|downregulation of externalization of phosphatidylserine|downregulation of phosphatidylserine exposure on apoptotic cell surface|inhibition of externalization of phosphatidylserine|inhibition of phosphatidylserine exposure on apoptotic cell surface|negative regulation of externalization of phosphatidylserine http://purl.obolibrary.org/obo/GO_1905781 GO:2000757 biolink:BiologicalProcess negative regulation of peptidyl-lysine acetylation Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation. go.json http://purl.obolibrary.org/obo/GO_2000757 GO:1905782 biolink:BiologicalProcess positive regulation of phosphatidylserine exposure on apoptotic cell surface Any process that activates or increases the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. go.json activation of externalization of phosphatidylserine|activation of phosphatidylserine exposure on apoptotic cell surface|positive regulation of externalization of phosphatidylserine|up regulation of externalization of phosphatidylserine|up regulation of phosphatidylserine exposure on apoptotic cell surface|up-regulation of externalization of phosphatidylserine|up-regulation of phosphatidylserine exposure on apoptotic cell surface|upregulation of externalization of phosphatidylserine|upregulation of phosphatidylserine exposure on apoptotic cell surface http://purl.obolibrary.org/obo/GO_1905782 GO:2000758 biolink:BiologicalProcess positive regulation of peptidyl-lysine acetylation Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation. go.json http://purl.obolibrary.org/obo/GO_2000758 GO:1905783 biolink:BiologicalProcess obsolete CENP-A containing nucleosome disassembly OBSOLETE. The disaggregation of a CENP-A containing nucleosome into its constituent components. go.json centromere specific nucleosome disassembly|centromere-specific nucleosome disassembly|centromeric nucleosome disassembly True http://purl.obolibrary.org/obo/GO_1905783 GO:2000759 biolink:BiologicalProcess regulation of N-terminal peptidyl-lysine acetylation Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation. go.json http://purl.obolibrary.org/obo/GO_2000759 GO:1905784 biolink:BiologicalProcess regulation of anaphase-promoting complex-dependent catabolic process Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. go.json http://purl.obolibrary.org/obo/GO_1905784 GO:1905774 biolink:BiologicalProcess regulation of DNA helicase activity Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity. go.json regulation of ATP-dependent DNA helicase activity http://purl.obolibrary.org/obo/GO_1905774 gocheck_do_not_annotate GO:1905775 biolink:BiologicalProcess negative regulation of DNA helicase activity Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity. go.json down regulation of ATP-dependent DNA helicase activity|down regulation of DNA helicase activity|down-regulation of ATP-dependent DNA helicase activity|down-regulation of DNA helicase activity|downregulation of ATP-dependent DNA helicase activity|downregulation of DNA helicase activity|inhibition of ATP-dependent DNA helicase activity|inhibition of DNA helicase activity|negative regulation of ATP-dependent DNA helicase activity http://purl.obolibrary.org/obo/GO_1905775 gocheck_do_not_annotate GO:1905776 biolink:BiologicalProcess positive regulation of DNA helicase activity Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity. go.json activation of ATP-dependent DNA helicase activity|activation of DNA helicase activity|positive regulation of ATP-dependent DNA helicase activity|up regulation of ATP-dependent DNA helicase activity|up regulation of DNA helicase activity|up-regulation of ATP-dependent DNA helicase activity|up-regulation of DNA helicase activity|upregulation of ATP-dependent DNA helicase activity|upregulation of DNA helicase activity http://purl.obolibrary.org/obo/GO_1905776 gocheck_do_not_annotate GO:1905777 biolink:BiologicalProcess regulation of exonuclease activity Any process that modulates the frequency, rate or extent of exonuclease activity. go.json regulation of exonuclease IX activity http://purl.obolibrary.org/obo/GO_1905777 gocheck_do_not_annotate GO:1905778 biolink:BiologicalProcess negative regulation of exonuclease activity Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity. go.json down regulation of exonuclease IX activity|down regulation of exonuclease activity|down-regulation of exonuclease IX activity|down-regulation of exonuclease activity|downregulation of exonuclease IX activity|downregulation of exonuclease activity|inhibition of exonuclease IX activity|inhibition of exonuclease activity|negative regulation of exonuclease IX activity http://purl.obolibrary.org/obo/GO_1905778 gocheck_do_not_annotate GO:2000750 biolink:BiologicalProcess negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000750 GO:1905779 biolink:BiologicalProcess positive regulation of exonuclease activity Any process that activates or increases the frequency, rate or extent of exonuclease activity. go.json activation of exonuclease IX activity|activation of exonuclease activity|positive regulation of exonuclease IX activity|up regulation of exonuclease IX activity|up regulation of exonuclease activity|up-regulation of exonuclease IX activity|up-regulation of exonuclease activity|upregulation of exonuclease IX activity|upregulation of exonuclease activity http://purl.obolibrary.org/obo/GO_1905779 gocheck_do_not_annotate GO:2000751 biolink:BiologicalProcess obsolete histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore OBSOLETE. Any histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore. go.json histone H3-T3 phosphorylation of CPC complex localization to kinetochore|histone H3-T3 phosphorylation of CPC localization to kinetochore|histone H3-T3 phosphorylation of chromosomal passenger complex localization to kinetochore|histone H3-T3 phosphorylation of chromosome passenger complex localisation to kinetochore|histone H3-T3 phosphorylation of chromosome passenger complex localization to kinetochore True http://purl.obolibrary.org/obo/GO_2000751 GO:2000752 biolink:BiologicalProcess regulation of glucosylceramide catabolic process Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process. go.json regulation of glucosylceramide breakdown|regulation of glucosylceramide catabolism|regulation of glucosylceramide degradation http://purl.obolibrary.org/obo/GO_2000752 GO:0051360 biolink:BiologicalProcess obsolete peptide cross-linking via L-asparagine 5-imidazolinone glycine OBSOLETE. The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. RESID:AA0380 go.json biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0051360 GO:0051361 biolink:BiologicalProcess obsolete peptide cross-linking via L-lysine 5-imidazolinone glycine OBSOLETE. The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. RESID:AA0381 go.json biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0051361 GO:0051364 biolink:BiologicalProcess N-terminal peptidyl-proline N-formylation The formylation of the N-terminal proline of proteins to form the derivative N-formylproline. RESID:AA0384 go.json http://purl.obolibrary.org/obo/GO_0051364 gocheck_do_not_annotate GO:0051365 biolink:BiologicalProcess cellular response to potassium ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions. go.json cellular response to K+ ion deprivation|cellular response to K+ ion starvation|cellular response to potassium ion deprivation|cellular response to potassium starvation http://purl.obolibrary.org/obo/GO_0051365 GO:0075310 biolink:BiologicalProcess regulation of sporangium development Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms. go.json http://purl.obolibrary.org/obo/GO_0075310 GO:0075311 biolink:BiologicalProcess positive regulation of sporangium development Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms. go.json http://purl.obolibrary.org/obo/GO_0075311 GO:0051362 biolink:BiologicalProcess obsolete peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine OBSOLETE. The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species. RESID:AA0382 go.json biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0051362 GO:0051363 biolink:BiologicalProcess peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. RESID:AA0383 go.json http://purl.obolibrary.org/obo/GO_0051363 gocheck_do_not_annotate GO:0075312 biolink:BiologicalProcess negative regulation of sporangium development Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms. go.json http://purl.obolibrary.org/obo/GO_0075312 GO:0051379 biolink:MolecularActivity epinephrine binding Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. go.json adrenaline binding http://purl.obolibrary.org/obo/GO_0051379 GO:0075346 biolink:BiologicalProcess obsolete modification by symbiont of host protein by ubiquitination OBSOLETE. The process in which an organism adds one or more ubiquitin groups to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification by symbiont of host protein by ubiquitinylation|modification by symbiont of host protein by ubiquitylation True http://purl.obolibrary.org/obo/GO_0075346 GO:0051377 biolink:MolecularActivity mannose-ethanolamine phosphotransferase activity Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. Reactome:R-HSA-162798 go.json EtN-P transferase activity|addition of ethanolamine phosphate to mannose of GPI precursor|ethanolamine phosphate transferase activity|phosphoethanolamine transferase activity http://purl.obolibrary.org/obo/GO_0051377 GO:0051378 biolink:MolecularActivity serotonin binding Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. go.json 5-hydroxytryptamine binding http://purl.obolibrary.org/obo/GO_0051378 GO:2000764 biolink:BiologicalProcess positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. go.json positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_2000764 GO:2000765 biolink:BiologicalProcess regulation of cytoplasmic translation Any process that modulates the frequency, rate or extent of cytoplasmic translation. go.json http://purl.obolibrary.org/obo/GO_2000765 GO:2000766 biolink:BiologicalProcess negative regulation of cytoplasmic translation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation. go.json http://purl.obolibrary.org/obo/GO_2000766 GO:1905790 biolink:BiologicalProcess regulation of mechanosensory behavior Any process that modulates the frequency, rate or extent of mechanosensory behavior. go.json regulation of behavioral response to mechanical stimulus|regulation of behavioural response to mechanical stimulus|regulation of mechanosensory behaviour http://purl.obolibrary.org/obo/GO_1905790 GO:1905791 biolink:BiologicalProcess negative regulation of mechanosensory behavior Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior. go.json down regulation of behavioral response to mechanical stimulus|down regulation of behavioural response to mechanical stimulus|down regulation of mechanosensory behavior|down regulation of mechanosensory behaviour|down-regulation of behavioral response to mechanical stimulus|down-regulation of behavioural response to mechanical stimulus|down-regulation of mechanosensory behavior|down-regulation of mechanosensory behaviour|downregulation of behavioral response to mechanical stimulus|downregulation of behavioural response to mechanical stimulus|downregulation of mechanosensory behavior|downregulation of mechanosensory behaviour|inhibition of behavioral response to mechanical stimulus|inhibition of behavioural response to mechanical stimulus|inhibition of mechanosensory behavior|inhibition of mechanosensory behaviour|negative regulation of behavioral response to mechanical stimulus|negative regulation of behavioural response to mechanical stimulus|negative regulation of mechanosensory behaviour http://purl.obolibrary.org/obo/GO_1905791 GO:2000767 biolink:BiologicalProcess positive regulation of cytoplasmic translation Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. go.json http://purl.obolibrary.org/obo/GO_2000767 GO:1905792 biolink:BiologicalProcess positive regulation of mechanosensory behavior Any process that activates or increases the frequency, rate or extent of mechanosensory behavior. go.json activation of behavioral response to mechanical stimulus|activation of behavioural response to mechanical stimulus|activation of mechanosensory behavior|activation of mechanosensory behaviour|positive regulation of behavioral response to mechanical stimulus|positive regulation of behavioural response to mechanical stimulus|positive regulation of mechanosensory behaviour|up regulation of behavioral response to mechanical stimulus|up regulation of behavioural response to mechanical stimulus|up regulation of mechanosensory behavior|up regulation of mechanosensory behaviour|up-regulation of behavioral response to mechanical stimulus|up-regulation of behavioural response to mechanical stimulus|up-regulation of mechanosensory behavior|up-regulation of mechanosensory behaviour|upregulation of behavioral response to mechanical stimulus|upregulation of behavioural response to mechanical stimulus|upregulation of mechanosensory behavior|upregulation of mechanosensory behaviour http://purl.obolibrary.org/obo/GO_1905792 GO:2000768 biolink:BiologicalProcess positive regulation of nephron tubule epithelial cell differentiation Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000768 GO:1905793 biolink:BiologicalProcess protein localization to pericentriolar material A process in which a protein is transported to, or maintained in, a location within a pericentriolar material. go.json protein localisation in pericentriolar material|protein localisation to pericentriolar material|protein localization in pericentriolar material http://purl.obolibrary.org/obo/GO_1905793 GO:2000769 biolink:BiologicalProcess regulation of establishment or maintenance of cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000769 GO:1905794 biolink:BiologicalProcess response to puromycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus. go.json response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine http://purl.obolibrary.org/obo/GO_1905794 GO:1905795 biolink:BiologicalProcess cellular response to puromycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus. go.json cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine http://purl.obolibrary.org/obo/GO_1905795 GO:1905785 biolink:BiologicalProcess negative regulation of anaphase-promoting complex-dependent catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. go.json http://purl.obolibrary.org/obo/GO_1905785 GO:1905786 biolink:BiologicalProcess positive regulation of anaphase-promoting complex-dependent catabolic process Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. go.json http://purl.obolibrary.org/obo/GO_1905786 GO:1905787 biolink:BiologicalProcess regulation of detection of mechanical stimulus involved in sensory perception of touch Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. go.json regulation of perception of touch, detection of mechanical stimulus|regulation of perception of touch, sensory detection of mechanical stimulus|regulation of perception of touch, sensory transduction of mechanical stimulus|regulation of sensory detection of mechanical stimulus during perception of touch|regulation of sensory transduction of mechanical stimulus during perception of touch|regulation of tactition, sensory detection of mechanical stimulus http://purl.obolibrary.org/obo/GO_1905787 GO:1905788 biolink:BiologicalProcess negative regulation of detection of mechanical stimulus involved in sensory perception of touch Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. go.json down regulation of detection of mechanical stimulus involved in sensory perception of touch|down regulation of perception of touch, detection of mechanical stimulus|down regulation of perception of touch, sensory detection of mechanical stimulus|down regulation of perception of touch, sensory transduction of mechanical stimulus|down regulation of sensory detection of mechanical stimulus during perception of touch|down regulation of sensory transduction of mechanical stimulus during perception of touch|down regulation of tactition, sensory detection of mechanical stimulus|down-regulation of detection of mechanical stimulus involved in sensory perception of touch|down-regulation of perception of touch, detection of mechanical stimulus|down-regulation of perception of touch, sensory detection of mechanical stimulus|down-regulation of perception of touch, sensory transduction of mechanical stimulus|down-regulation of sensory detection of mechanical stimulus during perception of touch|down-regulation of sensory transduction of mechanical stimulus during perception of touch|down-regulation of tactition, sensory detection of mechanical stimulus|downregulation of detection of mechanical stimulus involved in sensory perception of touch|downregulation of perception of touch, detection of mechanical stimulus|downregulation of perception of touch, sensory detection of mechanical stimulus|downregulation of perception of touch, sensory transduction of mechanical stimulus|downregulation of sensory detection of mechanical stimulus during perception of touch|downregulation of sensory transduction of mechanical stimulus during perception of touch|downregulation of tactition, sensory detection of mechanical stimulus|inhibition of detection of mechanical stimulus involved in sensory perception of touch|inhibition of perception of touch, detection of mechanical stimulus|inhibition of perception of touch, sensory detection of mechanical stimulus|inhibition of perception of touch, sensory transduction of mechanical stimulus|inhibition of sensory detection of mechanical stimulus during perception of touch|inhibition of sensory transduction of mechanical stimulus during perception of touch|inhibition of tactition, sensory detection of mechanical stimulus|negative regulation of perception of touch, detection of mechanical stimulus|negative regulation of perception of touch, sensory detection of mechanical stimulus|negative regulation of perception of touch, sensory transduction of mechanical stimulus|negative regulation of sensory detection of mechanical stimulus during perception of touch|negative regulation of sensory transduction of mechanical stimulus during perception of touch|negative regulation of tactition, sensory detection of mechanical stimulus http://purl.obolibrary.org/obo/GO_1905788 GO:1905789 biolink:BiologicalProcess positive regulation of detection of mechanical stimulus involved in sensory perception of touch Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. go.json activation of detection of mechanical stimulus involved in sensory perception of touch|activation of perception of touch, detection of mechanical stimulus|activation of perception of touch, sensory detection of mechanical stimulus|activation of perception of touch, sensory transduction of mechanical stimulus|activation of sensory detection of mechanical stimulus during perception of touch|activation of sensory transduction of mechanical stimulus during perception of touch|activation of tactition, sensory detection of mechanical stimulus|positive regulation of perception of touch, detection of mechanical stimulus|positive regulation of perception of touch, sensory detection of mechanical stimulus|positive regulation of perception of touch, sensory transduction of mechanical stimulus|positive regulation of sensory detection of mechanical stimulus during perception of touch|positive regulation of sensory transduction of mechanical stimulus during perception of touch|positive regulation of tactition, sensory detection of mechanical stimulus|up regulation of detection of mechanical stimulus involved in sensory perception of touch|up regulation of perception of touch, detection of mechanical stimulus|up regulation of perception of touch, sensory detection of mechanical stimulus|up regulation of perception of touch, sensory transduction of mechanical stimulus|up regulation of sensory detection of mechanical stimulus during perception of touch|up regulation of sensory transduction of mechanical stimulus during perception of touch|up regulation of tactition, sensory detection of mechanical stimulus|up-regulation of detection of mechanical stimulus involved in sensory perception of touch|up-regulation of perception of touch, detection of mechanical stimulus|up-regulation of perception of touch, sensory detection of mechanical stimulus|up-regulation of perception of touch, sensory transduction of mechanical stimulus|up-regulation of sensory detection of mechanical stimulus during perception of touch|up-regulation of sensory transduction of mechanical stimulus during perception of touch|up-regulation of tactition, sensory detection of mechanical stimulus|upregulation of detection of mechanical stimulus involved in sensory perception of touch|upregulation of perception of touch, detection of mechanical stimulus|upregulation of perception of touch, sensory detection of mechanical stimulus|upregulation of perception of touch, sensory transduction of mechanical stimulus|upregulation of sensory detection of mechanical stimulus during perception of touch|upregulation of sensory transduction of mechanical stimulus during perception of touch|upregulation of tactition, sensory detection of mechanical stimulus http://purl.obolibrary.org/obo/GO_1905789 GO:2000760 biolink:BiologicalProcess negative regulation of N-terminal peptidyl-lysine acetylation Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation. go.json http://purl.obolibrary.org/obo/GO_2000760 GO:2000761 biolink:BiologicalProcess positive regulation of N-terminal peptidyl-lysine acetylation Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation. go.json http://purl.obolibrary.org/obo/GO_2000761 GO:2000762 biolink:BiologicalProcess regulation of phenylpropanoid metabolic process Any process that modulates the frequency, rate or extent of phenylpropanoid metabolic process. go.json regulation of phenylpropanoid metabolism http://purl.obolibrary.org/obo/GO_2000762 GO:2000763 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in norepinephrine biosynthetic process. go.json positive regulation of transcription from Pol II promoter involved in levarterenol biosynthesis|positive regulation of transcription from Pol II promoter involved in levarterenol biosynthetic process|positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthesis|positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process|positive regulation of transcription from Pol II promoter involved in norepinephrine anabolism|positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthesis|positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthetic process|positive regulation of transcription from Pol II promoter involved in norepinephrine formation|positive regulation of transcription from Pol II promoter involved in norepinephrine synthesis True http://purl.obolibrary.org/obo/GO_2000763 GO:0051371 biolink:MolecularActivity muscle alpha-actinin binding Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. go.json alpha-actinin 2 binding|alpha-actinin 3 binding http://purl.obolibrary.org/obo/GO_0051371 GO:0051372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051372 GO:0075340 biolink:BiologicalProcess obsolete negative regulation of growth or development of symbiont during interaction with host OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. go.json negative regulation of growth or development of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0075340 GO:0075341 biolink:CellularComponent host cell PML body A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism. go.json host cell PML NB|host cell PML nuclear body http://purl.obolibrary.org/obo/GO_0075341 GO:0051370 biolink:MolecularActivity obsolete ZASP binding OBSOLETE. Binding to Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain. go.json Z-band alternatively spliced PDZ-motif protein binding|ZASP binding True http://purl.obolibrary.org/obo/GO_0051370 GO:0075342 biolink:BiologicalProcess symbiont-mediated disruption of host cell PML body The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by symbiont of host cell PML body|degradation by symbiont of host cell PML body|disassembly by symbiont of host cell PML NB|disassembly by symbiont of host cell PML body|disassembly by symbiont of host cell PML body during symbiotic interaction|disassembly by symbiont of host cell PML nuclear body|disruption by symbiont of host cell PML body http://purl.obolibrary.org/obo/GO_0075342 GO:0051375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051375 GO:0051376 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051376 GO:0075343 biolink:BiologicalProcess modulation by symbiont of abscisic acid levels in host The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075343 GO:0051373 biolink:MolecularActivity FATZ binding Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. go.json FATZ 1 binding|FATZ 2 binding|FATZ 3 binding|calsarcin 1 binding|calsarcin 2 binding|calsarcin 3 binding|calsarcin binding|filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle http://purl.obolibrary.org/obo/GO_0051373 GO:0075344 biolink:BiologicalProcess obsolete modulation by symbiont of host protein levels OBSOLETE. The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075344 GO:0075345 biolink:BiologicalProcess obsolete modification by symbiont of host protein OBSOLETE. The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075345 GO:0051374 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051374 GO:0075335 biolink:BiologicalProcess obsolete positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075335 GO:0075336 biolink:BiologicalProcess obsolete negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075336 GO:0051388 biolink:BiologicalProcess positive regulation of neurotrophin TRK receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. go.json activation of nerve growth factor receptor signaling pathway|positive regulation of NGF receptor signaling pathway|positive regulation of NGF receptor signalling pathway|positive regulation of nerve growth factor receptor signaling pathway|positive regulation of nerve growth factor receptor signalling pathway|stimulation of nerve growth factor receptor signaling pathway|up regulation of nerve growth factor receptor signaling pathway|up-regulation of nerve growth factor receptor signaling pathway|upregulation of nerve growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0051388 GO:0075337 biolink:BiologicalProcess obsolete positive regulation of growth or development of symbiont on or near host surface OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism. go.json positive regulation of growth or development of symbiont on or near host surface True http://purl.obolibrary.org/obo/GO_0075337 GO:0075338 biolink:BiologicalProcess obsolete modulation of growth or development of symbiont during interaction with host OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. go.json modulation of growth or development of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0075338 GO:0051389 biolink:BiologicalProcess obsolete inactivation of MAPKK activity OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK). go.json inactivation of MAP kinase kinase activity|termination of MAP kinase kinase activity|termination of MAPKK activity True http://purl.obolibrary.org/obo/GO_0051389 GO:0075339 biolink:BiologicalProcess obsolete positive regulation of growth or development of symbiont during interaction with host OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. go.json positive regulation of growth or development of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0075339 GO:2000775 biolink:BiologicalProcess obsolete histone H3-S10 phosphorylation involved in chromosome condensation OBSOLETE. Any histone H3-S10 phosphorylation that is involved in chromosome condensation. go.json histone H3 phosphorylation at S10 of chromosome condensation|histone H3-S10 phosphorylation of chromosome condensation True http://purl.obolibrary.org/obo/GO_2000775 GO:2000776 biolink:BiologicalProcess obsolete histone H4 acetylation involved in response to DNA damage stimulus OBSOLETE. Any histone H4 acetylation that is involved in a response to DNA damage stimulus. go.json histone H4 acetylation of DNA damage response|histone H4 acetylation of cellular DNA damage response|histone H4 acetylation of cellular response to DNA damage stimulus|histone H4 acetylation of response to DNA damage stimulus|histone H4 acetylation of response to genotoxic stress True http://purl.obolibrary.org/obo/GO_2000776 GO:2000777 biolink:BiologicalProcess positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia. go.json positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxic stress|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to lowered oxygen tension http://purl.obolibrary.org/obo/GO_2000777 GO:2000778 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000778 GO:2000779 biolink:BiologicalProcess regulation of double-strand break repair Any process that modulates the frequency, rate or extent of double-strand break repair. go.json http://purl.obolibrary.org/obo/GO_2000779 GO:1905796 biolink:BiologicalProcess regulation of intraciliary anterograde transport Any process that modulates the frequency, rate or extent of intraciliary anterograde transport. go.json regulation of intraflagellar anterograde transport http://purl.obolibrary.org/obo/GO_1905796 GO:1905797 biolink:BiologicalProcess negative regulation of intraciliary anterograde transport Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary anterograde transport. go.json down regulation of intraciliary anterograde transport|down regulation of intraflagellar anterograde transport|down-regulation of intraciliary anterograde transport|down-regulation of intraflagellar anterograde transport|downregulation of intraciliary anterograde transport|downregulation of intraflagellar anterograde transport|inhibition of intraciliary anterograde transport|inhibition of intraflagellar anterograde transport|negative regulation of intraflagellar anterograde transport http://purl.obolibrary.org/obo/GO_1905797 GO:1905798 biolink:BiologicalProcess positive regulation of intraciliary anterograde transport Any process that activates or increases the frequency, rate or extent of intraciliary anterograde transport. go.json activation of intraciliary anterograde transport|activation of intraflagellar anterograde transport|positive regulation of intraflagellar anterograde transport|up regulation of intraciliary anterograde transport|up regulation of intraflagellar anterograde transport|up-regulation of intraciliary anterograde transport|up-regulation of intraflagellar anterograde transport|upregulation of intraciliary anterograde transport|upregulation of intraflagellar anterograde transport http://purl.obolibrary.org/obo/GO_1905798 GO:1905799 biolink:BiologicalProcess regulation of intraciliary retrograde transport Any process that modulates the frequency, rate or extent of intraciliary retrograde transport. go.json regulation of intraflagellar retrograde transport http://purl.obolibrary.org/obo/GO_1905799 GO:2000770 biolink:BiologicalProcess negative regulation of establishment or maintenance of cell polarity regulating cell shape Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000770 GO:2000771 biolink:BiologicalProcess positive regulation of establishment or maintenance of cell polarity regulating cell shape Any process that activates or increases the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000771 GO:2000772 biolink:BiologicalProcess regulation of cellular senescence Any process that modulates the frequency, rate or extent of cellular senescence. go.json http://purl.obolibrary.org/obo/GO_2000772 GO:2000773 biolink:BiologicalProcess negative regulation of cellular senescence Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. go.json http://purl.obolibrary.org/obo/GO_2000773 GO:2000774 biolink:BiologicalProcess positive regulation of cellular senescence Any process that activates or increases the frequency, rate or extent of cellular senescence. go.json http://purl.obolibrary.org/obo/GO_2000774 GO:0051382 biolink:BiologicalProcess kinetochore assembly The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. go.json NMS complex assembly|centromere and kinetochore complex maturation|centromere/kinetochore complex maturation|chromosome-kinetochore attachment|kinetochore formation http://purl.obolibrary.org/obo/GO_0051382 GO:0051383 biolink:BiologicalProcess kinetochore organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. go.json kinetochore organisation|kinetochore organization and biogenesis http://purl.obolibrary.org/obo/GO_0051383 GO:0051380 biolink:MolecularActivity norepinephrine binding Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. go.json noradrenaline binding http://purl.obolibrary.org/obo/GO_0051380 GO:0075330 biolink:BiologicalProcess positive regulation of arbuscule formation for nutrient acquisition from host Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075330 GO:0051381 biolink:MolecularActivity histamine binding Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json http://purl.obolibrary.org/obo/GO_0051381 GO:0051386 biolink:BiologicalProcess regulation of neurotrophin TRK receptor signaling pathway Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. go.json regulation of NGF receptor signaling pathway|regulation of NGF receptor signalling pathway|regulation of nerve growth factor receptor signaling pathway|regulation of nerve growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0051386 GO:0075331 biolink:BiologicalProcess negative regulation of arbuscule formation for nutrient acquisition from host Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0075331 GO:0051387 biolink:BiologicalProcess negative regulation of neurotrophin TRK receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. go.json down regulation of nerve growth factor receptor signaling pathway|down-regulation of nerve growth factor receptor signaling pathway|downregulation of nerve growth factor receptor signaling pathway|inhibition of nerve growth factor receptor signaling pathway|negative regulation of NGF receptor signaling pathway|negative regulation of NGF receptor signalling pathway|negative regulation of nerve growth factor receptor signaling pathway|negative regulation of nerve growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0051387 GO:0075332 biolink:BiologicalProcess obsolete modulation by host of symbiont adenylate cyclase-mediated signal transduction OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075332 GO:0051384 biolink:BiologicalProcess response to glucocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. go.json response to glucocorticoid stimulus http://purl.obolibrary.org/obo/GO_0051384 GO:0075333 biolink:BiologicalProcess obsolete positive regulation by host of symbiont adenylate cyclase-mediated signal transduction OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075333 GO:0051385 biolink:BiologicalProcess response to mineralocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. go.json response to mineralocorticoid stimulus http://purl.obolibrary.org/obo/GO_0051385 GO:0075334 biolink:BiologicalProcess obsolete modulation of symbiont adenylate cyclase-mediated signal transduction in response to host OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0075334 GO:2000706 biolink:BiologicalProcess negative regulation of dense core granule biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis. go.json http://purl.obolibrary.org/obo/GO_2000706 GO:2000707 biolink:BiologicalProcess positive regulation of dense core granule biogenesis Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis. go.json http://purl.obolibrary.org/obo/GO_2000707 GO:0051399 biolink:MolecularActivity obsolete N-terminal arginine aminopeptidase activity OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain. go.json N-terminal arginine aminopeptidase activity|arginine aminopeptidase activity|argininyl aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0051399 GO:2000708 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000708 GO:2000709 biolink:BiologicalProcess regulation of maintenance of meiotic sister chromatid cohesion, centromeric Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. go.json regulation of maintenance of centromeric meiotic sister chromatin cohesion|regulation of maintenance of meiotic sister chromatin cohesion at centromere|regulation of maintenance of sister chromatin cohesion at centromere at meiosis I http://purl.obolibrary.org/obo/GO_2000709 GO:2000700 biolink:BiologicalProcess positive regulation of cardiac muscle cell myoblast differentiation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. go.json positive regulation of cardiac myoblast differentiation|positive regulation of myocardial precursor cell differentiation http://purl.obolibrary.org/obo/GO_2000700 GO:2000701 biolink:BiologicalProcess glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct. go.json GDNF receptor signaling pathway of ureteric bud formation|glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation|glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation|glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation|glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000701 GO:2000702 biolink:BiologicalProcess regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation. go.json regulation of FGF receptor signaling pathway of ureteric bud formation|regulation of FGF receptor signalling pathway of ureteric bud formation|regulation of FGFR signaling pathway of ureteric bud formation|regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation|regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000702 GO:2000703 biolink:BiologicalProcess negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation. go.json negative regulation of FGF receptor signaling pathway of ureteric bud formation|negative regulation of FGF receptor signalling pathway of ureteric bud formation|negative regulation of FGFR signaling pathway of ureteric bud formation|negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation|negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000703 GO:2000704 biolink:BiologicalProcess positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation. go.json positive regulation of FGF receptor signaling pathway of ureteric bud formation|positive regulation of FGF receptor signalling pathway of ureteric bud formation|positive regulation of FGFR signaling pathway of ureteric bud formation|positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation|positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000704 GO:2000705 biolink:BiologicalProcess regulation of dense core granule biogenesis Any process that modulates the frequency, rate or extent of dense core granule biogenesis. go.json http://purl.obolibrary.org/obo/GO_2000705 GO:0051390 biolink:BiologicalProcess obsolete inactivation of MAPKKK activity OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase kinase (MAPKKK). go.json inactivation of MAP kinase kinase kinase activity|termination of MAP kinase kinase kinase activity|termination of MAPKKK activity True http://purl.obolibrary.org/obo/GO_0051390 GO:0051393 biolink:MolecularActivity alpha-actinin binding Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. go.json alpha-actinin 1 binding|alpha-actinin 4 binding|nonmuscle alpha-actinin binding http://purl.obolibrary.org/obo/GO_0051393 GO:0051394 biolink:BiologicalProcess regulation of nerve growth factor receptor activity Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. go.json regulation of NGF receptor activity http://purl.obolibrary.org/obo/GO_0051394 gocheck_do_not_annotate GO:0051391 biolink:BiologicalProcess tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json http://purl.obolibrary.org/obo/GO_0051391 GO:0051392 biolink:MolecularActivity tRNA N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA. go.json tRNA cytidine N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0051392 GO:0051397 biolink:MolecularActivity obsolete N-terminal basic amino acid aminopeptidase activity OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain. go.json N-terminal basic amino acid aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0051397 GO:0051398 biolink:MolecularActivity obsolete N-terminal lysine aminopeptidase activity OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain. go.json N-terminal lysine aminopeptidase activity|lysine aminopeptidase activity|lysyl aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0051398 GO:0051395 biolink:BiologicalProcess negative regulation of nerve growth factor receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. go.json down regulation of nerve growth factor receptor activity|down-regulation of nerve growth factor receptor activity|downregulation of nerve growth factor receptor activity|inhibition of nerve growth factor receptor activity|negative regulation of NGF receptor activity http://purl.obolibrary.org/obo/GO_0051395 gocheck_do_not_annotate GO:0051396 biolink:BiologicalProcess positive regulation of nerve growth factor receptor activity Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. go.json activation of nerve growth factor receptor activity|positive regulation of NGF receptor activity|stimulation of nerve growth factor receptor activity|up regulation of nerve growth factor receptor activity|up-regulation of nerve growth factor receptor activity|upregulation of nerve growth factor receptor activity http://purl.obolibrary.org/obo/GO_0051396 gocheck_do_not_annotate GO:2000717 biolink:BiologicalProcess positive regulation of maintenance of mitotic sister chromatid cohesion, arms Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms. go.json positive regulation of maintenance of mitotic sister chromatin cohesion along arms|positive regulation of maintenance of sister chromatin cohesion along arms at mitosis http://purl.obolibrary.org/obo/GO_2000717 GO:2000718 biolink:BiologicalProcess regulation of maintenance of mitotic sister chromatid cohesion, centromeric Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. go.json regulation of maintenance of centromeric mitotic sister chromatin cohesion|regulation of maintenance of mitotic sister chromatin cohesion at centromere|regulation of maintenance of sister chromatin cohesion at centromere at mitosis http://purl.obolibrary.org/obo/GO_2000718 GO:2000719 biolink:BiologicalProcess negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. go.json negative regulation of maintenance of centromeric mitotic sister chromatin cohesion|negative regulation of maintenance of mitotic sister chromatin cohesion at centromere|negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis http://purl.obolibrary.org/obo/GO_2000719 GO:2000710 biolink:BiologicalProcess negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. go.json negative regulation of maintenance of centromeric meiotic sister chromatin cohesion|negative regulation of maintenance of meiotic sister chromatin cohesion at centromere|negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I http://purl.obolibrary.org/obo/GO_2000710 GO:2000711 biolink:BiologicalProcess positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. go.json positive regulation of maintenance of centromeric meiotic sister chromatin cohesion|positive regulation of maintenance of meiotic sister chromatin cohesion at centromere|positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I http://purl.obolibrary.org/obo/GO_2000711 GO:2000712 biolink:BiologicalProcess obsolete regulation of maintenance of meiotic sister chromatid cohesion, arms OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms. go.json regulation of maintenance of meiotic sister chromatin cohesion along arms|regulation of maintenance of sister chromatin cohesion along arms at meiosis I True http://purl.obolibrary.org/obo/GO_2000712 GO:2000713 biolink:BiologicalProcess obsolete negative regulation of maintenance of meiotic sister chromatid cohesion, arms OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms. go.json negative regulation of maintenance of meiotic sister chromatin cohesion along arms|negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I True http://purl.obolibrary.org/obo/GO_2000713 GO:2000714 biolink:BiologicalProcess obsolete positive regulation of maintenance of meiotic sister chromatid cohesion, arms OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms. go.json positive regulation of maintenance of meiotic sister chromatin cohesion along arms|positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I True http://purl.obolibrary.org/obo/GO_2000714 GO:2000715 biolink:BiologicalProcess regulation of maintenance of mitotic sister chromatid cohesion, arms Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms. go.json regulation of maintenance of mitotic sister chromatin cohesion along arms|regulation of maintenance of sister chromatin cohesion along arms at mitosis http://purl.obolibrary.org/obo/GO_2000715 GO:2000716 biolink:BiologicalProcess negative regulation of maintenance of mitotic sister chromatid cohesion, arms Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms. go.json negative regulation of maintenance of mitotic sister chromatin cohesion along arms|negative regulation of maintenance of sister chromatin cohesion along arms at mitosis http://purl.obolibrary.org/obo/GO_2000716 GO:2000728 biolink:BiologicalProcess regulation of mRNA export from nucleus in response to heat stress Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress. go.json regulation of mRNA export from cell nucleus during heat stress|regulation of mRNA export from nucleus during heat stress http://purl.obolibrary.org/obo/GO_2000728 GO:2000729 biolink:BiologicalProcess positive regulation of mesenchymal cell proliferation involved in ureter development Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development. go.json positive regulation of ureter mesenchymal cell proliferation|positive regulation of ureteral mesenchymal cell proliferation http://purl.obolibrary.org/obo/GO_2000729 GO:2000720 biolink:BiologicalProcess positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. go.json positive regulation of maintenance of centromeric mitotic sister chromatin cohesion|positive regulation of maintenance of mitotic sister chromatin cohesion at centromere|positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis http://purl.obolibrary.org/obo/GO_2000720 GO:2000721 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation. go.json activation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|activation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation|activation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|activation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation|positive regulation of gene-specific transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|positive regulation of gene-specific transcription from RNA polymerase II promoter of smooth muscle cell differentiation|positive regulation of global transcription from Pol II promoter of nonstriated muscle cell differentiation|positive regulation of global transcription from Pol II promoter of smooth muscle cell differentiation|positive regulation of transcription from Pol II promoter of nonstriated muscle cell differentiation|positive regulation of transcription from Pol II promoter of smooth muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter, global of nonstriated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter, global of smooth muscle cell differentiation|stimulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|stimulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation|stimulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|stimulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation|up regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|up regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation|up regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|up regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation|up-regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|up-regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation|up-regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|up-regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation|upregulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation|upregulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation True http://purl.obolibrary.org/obo/GO_2000721 GO:2000722 biolink:BiologicalProcess regulation of cardiac vascular smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation. go.json regulation of heart vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_2000722 GO:2000723 biolink:BiologicalProcess negative regulation of cardiac vascular smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation. go.json negative regulation of heart vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_2000723 GO:2000724 biolink:BiologicalProcess positive regulation of cardiac vascular smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation. go.json positive regulation of heart vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_2000724 GO:2000725 biolink:BiologicalProcess regulation of cardiac muscle cell differentiation Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. go.json regulation of cardiomyocyte differentiation|regulation of heart muscle cell differentiation http://purl.obolibrary.org/obo/GO_2000725 GO:2000726 biolink:BiologicalProcess negative regulation of cardiac muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. go.json negative regulation of cardiomyocyte differentiation|negative regulation of heart muscle cell differentiation http://purl.obolibrary.org/obo/GO_2000726 GO:2000727 biolink:BiologicalProcess positive regulation of cardiac muscle cell differentiation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. go.json positive regulation of cardiomyocyte differentiation|positive regulation of heart muscle cell differentiation http://purl.obolibrary.org/obo/GO_2000727 GO:2000739 biolink:BiologicalProcess regulation of mesenchymal stem cell differentiation Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000739 GO:2000731 biolink:BiologicalProcess negative regulation of termination of RNA polymerase I transcription Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription. go.json negative regulation of RNA polymerase I transcription termination|negative regulation of transcription termination from Pol I promoter|negative regulation of transcription termination from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_2000731 GO:2000732 biolink:BiologicalProcess positive regulation of termination of RNA polymerase I transcription Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription. go.json positive regulation of RNA polymerase I transcription termination|positive regulation of transcription termination from Pol I promoter|positive regulation of transcription termination from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_2000732 GO:2000733 biolink:BiologicalProcess regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. go.json regulation of GDNF receptor signaling pathway of ureteric bud formation|regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation|regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation|regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation|regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000733 GO:2000734 biolink:BiologicalProcess negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. go.json negative regulation of GDNF receptor signaling pathway of ureteric bud formation|negative regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation|negative regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000734 GO:2000735 biolink:BiologicalProcess positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. go.json positive regulation of GDNF receptor signaling pathway of ureteric bud formation|positive regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation|positive regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation|positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation|positive regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000735 GO:2000736 biolink:BiologicalProcess regulation of stem cell differentiation Any process that modulates the frequency, rate or extent of stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000736 GO:2000737 biolink:BiologicalProcess negative regulation of stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000737 GO:2000738 biolink:BiologicalProcess positive regulation of stem cell differentiation Any process that activates or increases the frequency, rate or extent of stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000738 GO:2000730 biolink:BiologicalProcess regulation of termination of RNA polymerase I transcription Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription. go.json regulation of RNA polymerase I transcription termination|regulation of transcription termination from Pol I promoter|regulation of transcription termination from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_2000730 GO:0002346 biolink:BiologicalProcess B cell positive selection Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor. go.json B lymphocyte positive selection|B-cell positive selection|B-lymphocyte positive selection http://purl.obolibrary.org/obo/GO_0002346 GO:0002347 biolink:BiologicalProcess response to tumor cell Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. go.json http://purl.obolibrary.org/obo/GO_0002347 GO:0002348 biolink:BiologicalProcess central B cell positive selection Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors. go.json central B lymphocyte positive selection|central B-cell positive selection|central B-lymphocyte positive selection http://purl.obolibrary.org/obo/GO_0002348 GO:0002349 biolink:BiologicalProcess histamine production involved in inflammatory response The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json histamine production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002349 GO:0002342 biolink:BiologicalProcess central B cell deletion The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection. go.json central B lymphocyte deletion|central B-cell deletion|central B-lymphocyte deletion http://purl.obolibrary.org/obo/GO_0002342 GO:0002343 biolink:BiologicalProcess peripheral B cell selection Any B cell selection process that occurs in the periphery. go.json peripheral B lymphocyte selection|peripheral B-cell selection|peripheral B-lymphocyte selection http://purl.obolibrary.org/obo/GO_0002343 GO:0002344 biolink:BiologicalProcess B cell affinity maturation The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen. go.json B lymphocyte affinity maturation|B-cell affinity maturation|B-lymphocyte affinity maturation http://purl.obolibrary.org/obo/GO_0002344 GO:0002345 biolink:BiologicalProcess peripheral B cell receptor editing The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation. go.json peripheral B lymphocyte receptor editing|peripheral B-cell receptor editing|peripheral B-lymphocyte receptor editing http://purl.obolibrary.org/obo/GO_0002345 GO:0002340 biolink:BiologicalProcess central B cell selection Any B cell selection process that occurs in the bone marrow. go.json central B lymphocyte selection|central B-cell selection|central B-lymphocyte selection http://purl.obolibrary.org/obo/GO_0002340 GO:0002341 biolink:BiologicalProcess central B cell anergy Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow. go.json central B lymphocyte anergy|central B-cell anergy|central B-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002341 GO:0016987 biolink:MolecularActivity sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. go.json DNA-dependent RNA polymerase promoter selection factor|bacterial sigma factor activity|core DNA-dependent RNA polymerase binding promoter specificity activity|plastid sigma factor activity|promoter selection factor activity|sigma transcription factor http://purl.obolibrary.org/obo/GO_0016987 GO:0016988 biolink:MolecularActivity obsolete transcription initiation factor antagonist activity OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity. go.json transcription initiation factor antagonist activity|transcriptional initiation factor antagonist activity True http://purl.obolibrary.org/obo/GO_0016988 GO:0016989 biolink:MolecularActivity sigma factor antagonist activity The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. go.json anti-sigma factor activity http://purl.obolibrary.org/obo/GO_0016989 GO:0016983 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016983 GO:0016984 biolink:MolecularActivity ribulose-bisphosphate carboxylase activity Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O. EC:4.1.1.39|MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN|RHEA:23124 go.json D-ribulose 1,5-diphosphate carboxylase activity|D-ribulose-1,5-bisphosphate carboxylase activity|RuBP carboxylase activity|RuBisCO activity|carboxydismutase activity|diphosphoribulose carboxylase activity|ribulose 1,5-bisphosphate carboxylase activity|ribulose 1,5-bisphosphate carboxylase/oxygenase activity|ribulose 1,5-diphosphate carboxylase activity|ribulose 1,5-diphosphate carboxylase/oxygenase activity|ribulose bisphosphate carboxylase/oxygenase activity|ribulose diphosphate carboxylase activity|ribulose diphosphate carboxylase/oxygenase activity http://purl.obolibrary.org/obo/GO_0016984 GO:0016985 biolink:MolecularActivity mannan endo-1,4-beta-mannosidase activity Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans. EC:3.2.1.78|MetaCyc:3.2.1.78-RXN go.json 1,4-beta-D-mannan mannanohydrolase activity|beta-1,4-mannan 4-mannanohydrolase activity|beta-D-mannanase activity|beta-mannanase B|beta-mannanase activity|endo-1,4-beta-mannanase activity|endo-1,4-mannanase activity|endo-beta-1,4-mannase activity|endo-beta-mannanase activity http://purl.obolibrary.org/obo/GO_0016985 GO:0016986 biolink:MolecularActivity obsolete transcription initiation factor activity OBSOLETE. Plays a role in regulating transcription initiation. go.json transcription initiation factor activity|transcriptional initiation factor activity True http://purl.obolibrary.org/obo/GO_0016986 GO:0016980 biolink:MolecularActivity creatinase activity Catalysis of the reaction: creatine + H2O = sarcosine + urea. EC:3.5.3.3|KEGG_REACTION:R01566|MetaCyc:CREATINASE-RXN|RHEA:22456 go.json creatine amidinohydrolase activity http://purl.obolibrary.org/obo/GO_0016980 GO:0016982 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016982 GO:0002357 biolink:BiologicalProcess defense response to tumor cell Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. go.json http://purl.obolibrary.org/obo/GO_0002357 GO:0002358 biolink:BiologicalProcess B cell homeostatic proliferation The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus. go.json B lymphocyte homeostatic proliferation|B-cell homeostatic proliferation|B-lymphocyte homeostatic proliferation http://purl.obolibrary.org/obo/GO_0002358 GO:0002359 biolink:BiologicalProcess B-1 B cell proliferation The expansion of a B-1 B cell by cell division. Follows B cell activation. go.json B-1 B lymphocyte proliferation|B-1 B-cell proliferation|B-1 B-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0002359 GO:0002353 biolink:BiologicalProcess plasma kallikrein-kinin cascade A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. go.json http://purl.obolibrary.org/obo/GO_0002353 GO:0002354 biolink:BiologicalProcess central B cell negative selection Any process leading to negative selection of B cells in the bone marrow. go.json central B lymphocyte negative selection|central B-cell negative selection|central B-lymphocyte negative selection http://purl.obolibrary.org/obo/GO_0002354 GO:0002355 biolink:BiologicalProcess detection of tumor cell The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0002355 GO:0002356 biolink:BiologicalProcess peripheral B cell negative selection Any process leading to negative selection of B cells in the periphery. go.json peripheral B lymphocyte negative selection|peripheral B-cell negative selection|peripheral B-lymphocyte negative selection http://purl.obolibrary.org/obo/GO_0002356 GO:0002350 biolink:BiologicalProcess peripheral B cell positive selection Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors. go.json peripheral B lymphocyte positive selection|peripheral B-cell positive selection|peripheral B-lymphocyte positive selection http://purl.obolibrary.org/obo/GO_0002350 GO:0002351 biolink:BiologicalProcess serotonin production involved in inflammatory response The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json serotonin production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002351 GO:0002352 biolink:BiologicalProcess B cell negative selection Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion. go.json B lymphocyte negative selection|B-cell negative selection|B-lymphocyte negative selection http://purl.obolibrary.org/obo/GO_0002352 GO:0016998 biolink:BiologicalProcess cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. go.json cell wall breakdown|cell wall catabolism|cell wall degradation|cellular cell wall macromolecule breakdown|cellular cell wall macromolecule catabolic process|cellular cell wall macromolecule catabolism|cellular cell wall macromolecule degradation http://purl.obolibrary.org/obo/GO_0016998 GO:0016999 biolink:BiologicalProcess antibiotic metabolic process The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. go.json antibiotic metabolism http://purl.obolibrary.org/obo/GO_0016999 GO:0016994 biolink:MolecularActivity precorrin-6A reductase activity Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+. EC:1.3.1.54|MetaCyc:1.3.1.54-RXN|RHEA:23408 go.json precorrin-6B:NADP+ oxidoreductase activity|precorrin-6X reductase activity|precorrin-6Y:NADP(+) oxidoreductase activity|precorrin-6Y:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016994 GO:0016995 biolink:MolecularActivity cholesterol oxidase activity Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2. EC:1.1.3.6|KEGG_REACTION:R01459|MetaCyc:CHOLESTEROL-OXIDASE-RXN|RHEA:32183 go.json 3beta-hydroxy steroid oxidoreductase activity|3beta-hydroxysteroid:oxygen oxidoreductase activity|cholesterol- O2 oxidoreductase activity|cholesterol-O2 oxidoreductase activity|cholesterol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016995 GO:0016996 biolink:MolecularActivity endo-alpha-(2,8)-sialidase activity Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids. EC:3.2.1.129|MetaCyc:3.2.1.129-RXN go.json alpha-2,8-sialosylhydrolase activity|endo-N-acetylneuraminidase activity|endo-N-acylneuraminidase activity|endoneuraminidase activity|endosialidase activity|poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity|poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity|polysialoside (2->8)-alpha-sialosylhydrolase activity http://purl.obolibrary.org/obo/GO_0016996 GO:0016997 biolink:MolecularActivity alpha-sialidase activity Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. go.json http://purl.obolibrary.org/obo/GO_0016997 GO:0016990 biolink:MolecularActivity arginine deiminase activity Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. EC:3.5.3.6|MetaCyc:ARGININE-DEIMINASE-RXN|RHEA:19597 go.json L-arginine deiminase activity|L-arginine iminohydrolase activity|arginine dihydrolase activity|citrulline iminase activity http://purl.obolibrary.org/obo/GO_0016990 GO:0016991 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016991 GO:0016992 biolink:MolecularActivity lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. EC:2.8.1.8|MetaCyc:RXN-14950|MetaCyc:RXN-14957|MetaCyc:RXN-14959|MetaCyc:RXN0-949|RHEA:16585|Reactome:R-HSA-6793591 go.json LS|LipA|lipoic acid synthase|lipoyl synthase activity|protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity|protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity http://purl.obolibrary.org/obo/GO_0016992 GO:0016993 biolink:MolecularActivity precorrin-8X methylmutase activity Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. EC:5.4.99.61|MetaCyc:5.4.1.2-RXN|RHEA:22512 go.json HBA synthase activity|hydrogenobyrinic acid-binding protein activity|precorrin isomerase activity|precorrin-8X 11,12-methylmutase activity http://purl.obolibrary.org/obo/GO_0016993 GO:0002324 biolink:BiologicalProcess natural killer cell proliferation involved in immune response The expansion of a natural killer cell population by cell division as part of an immune response. go.json NK cell proliferation during immune response|natural killer cell proliferation during immune response http://purl.obolibrary.org/obo/GO_0002324 GO:0002325 biolink:BiologicalProcess natural killer cell differentiation involved in immune response The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response. go.json NK cell differentiation during immune response|natural killer cell development involved in immune response|natural killer cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0002325 GO:0002326 biolink:BiologicalProcess B cell lineage commitment The process in which a lymphoid progenitor cell becomes committed to become any type of B cell. go.json B lymphocyte lineage commitment|B-cell lineage commitment|B-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002326 GO:0002327 biolink:BiologicalProcess immature B cell differentiation The process in which a precursor cell type acquires the specialized features of an immature B cell. go.json immature B cell development|immature B lymphocyte differentiation|immature B-cell differentiation|immature B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002327 GO:0002320 biolink:BiologicalProcess lymphoid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. go.json http://purl.obolibrary.org/obo/GO_0002320 GO:0002321 biolink:BiologicalProcess natural killer cell progenitor differentiation The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor. go.json http://purl.obolibrary.org/obo/GO_0002321 GO:0002322 biolink:BiologicalProcess B cell proliferation involved in immune response The expansion of a B cell population by cell division following B cell activation during an immune response. go.json B cell proliferation during immune response|B lymphocyte proliferation during immune response|B-cell proliferation during immune response|B-lymphocyte proliferation during immune response http://purl.obolibrary.org/obo/GO_0002322 GO:0002323 biolink:BiologicalProcess natural killer cell activation involved in immune response The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json NK cell activation during immune response|natural killer cell activation during immune response http://purl.obolibrary.org/obo/GO_0002323 GO:0016969 biolink:MolecularActivity obsolete hemerythrin OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans. go.json hemerythrin True http://purl.obolibrary.org/obo/GO_0016969 GO:0016965 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016965 GO:0016966 biolink:MolecularActivity nitric oxide reductase activity Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide. EC:1.7.2.5|KEGG_REACTION:R00294|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN|RHEA:30211 go.json CYP55|P450 nitric oxide reductase activity|P450nor|cytochrome bc nitric oxide reductase activity|nitric-oxide reductase activity|nitrogen oxide reductase activity|nitrous-oxide:(acceptor) oxidoreductase (NO-forming)|nitrous-oxide:acceptor oxidoreductase (NO-forming) http://purl.obolibrary.org/obo/GO_0016966 GO:0016967 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016967 GO:1905700 biolink:BiologicalProcess negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json down regulation of drug transmembrane export|down-regulation of drug transmembrane export|downregulation of drug transmembrane export|inhibition of drug transmembrane export|negative regulation of drug transmembrane export|negative regulation of xenobiotic transmembrane export http://purl.obolibrary.org/obo/GO_1905700 GO:0016968 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016968 GO:1905701 biolink:BiologicalProcess positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane Any process that activates or increases the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json activation of drug transmembrane export|positive regulation of drug transmembrane export|positive regulation of xenobiotic transmembrane export|up regulation of drug transmembrane export|up-regulation of drug transmembrane export|upregulation of drug transmembrane export http://purl.obolibrary.org/obo/GO_1905701 GO:0016961 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016961 GO:1905702 biolink:BiologicalProcess regulation of inhibitory synapse assembly Any process that modulates the frequency, rate or extent of inhibitory synapse assembly. go.json regulation of inhibitory synapse formation http://purl.obolibrary.org/obo/GO_1905702 GO:0016962 biolink:MolecularActivity obsolete receptor-associated protein activity OBSOLETE. (Was not defined before being made obsolete). go.json receptor-associated protein activity True http://purl.obolibrary.org/obo/GO_0016962 GO:1905703 biolink:BiologicalProcess negative regulation of inhibitory synapse assembly Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory synapse assembly. go.json down regulation of inhibitory synapse assembly|down regulation of inhibitory synapse formation|down-regulation of inhibitory synapse assembly|down-regulation of inhibitory synapse formation|downregulation of inhibitory synapse assembly|downregulation of inhibitory synapse formation|inhibition of inhibitory synapse assembly|inhibition of inhibitory synapse formation|negative regulation of inhibitory synapse formation http://purl.obolibrary.org/obo/GO_1905703 GO:0016963 biolink:MolecularActivity obsolete alpha-2 macroglobulin receptor-associated protein activity OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains. go.json alpha-2 macroglobulin receptor-associated protein activity True http://purl.obolibrary.org/obo/GO_0016963 GO:1905704 biolink:BiologicalProcess positive regulation of inhibitory synapse assembly Any process that activates or increases the frequency, rate or extent of inhibitory synapse assembly. go.json activation of inhibitory synapse assembly|activation of inhibitory synapse formation|positive regulation of inhibitory synapse formation|up regulation of inhibitory synapse assembly|up regulation of inhibitory synapse formation|up-regulation of inhibitory synapse assembly|up-regulation of inhibitory synapse formation|upregulation of inhibitory synapse assembly|upregulation of inhibitory synapse formation http://purl.obolibrary.org/obo/GO_1905704 GO:0016964 biolink:MolecularActivity alpha-2 macroglobulin receptor activity Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis. go.json http://purl.obolibrary.org/obo/GO_0016964 GO:1905705 biolink:BiologicalProcess obsolete cellular response to paclitaxel OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus. go.json True http://purl.obolibrary.org/obo/GO_1905705 GO:1905706 biolink:BiologicalProcess regulation of mitochondrial ATP synthesis coupled proton transport Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport. go.json http://purl.obolibrary.org/obo/GO_1905706 GO:1905707 biolink:BiologicalProcess negative regulation of mitochondrial ATP synthesis coupled proton transport Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport. go.json http://purl.obolibrary.org/obo/GO_1905707 GO:1905708 biolink:BiologicalProcess regulation of cell morphogenesis involved in conjugation with cellular fusion Any process that modulates the location, frequency, rate or extent of cell morphogenesis involved in conjugation with cellular fusion. go.json regulation of shmoo orientation|regulation of shmooing http://purl.obolibrary.org/obo/GO_1905708 GO:0016960 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016960 GO:0002328 biolink:BiologicalProcess pro-B cell differentiation The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed. go.json pro-B cell development|pro-B lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002328 GO:1905709 biolink:BiologicalProcess negative regulation of membrane permeability Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane. go.json http://purl.obolibrary.org/obo/GO_1905709 GO:0002329 biolink:BiologicalProcess pre-B cell differentiation The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments. go.json pre-B cell development|pre-B lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002329 GO:0051302 biolink:BiologicalProcess regulation of cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. go.json http://purl.obolibrary.org/obo/GO_0051302 GO:0002335 biolink:BiologicalProcess mature B cell differentiation The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. go.json mature B lymphocyte differentiation|mature B-cell differentiation|mature B-lymphocyte differentiation|mature cell development http://purl.obolibrary.org/obo/GO_0002335 GO:0002336 biolink:BiologicalProcess B-1 B cell lineage commitment The process in which an immature B cell becomes committed to become a B-1 B cell. go.json B-1 B lymphocyte lineage commitment|B-1 B-cell lineage commitment|B-1 B-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002336 GO:0051303 biolink:BiologicalProcess establishment of chromosome localization The directed movement of a chromosome to a specific location. go.json chromosome positioning|establishment of chromosome localisation http://purl.obolibrary.org/obo/GO_0051303 GO:0051300 biolink:BiologicalProcess spindle pole body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome. go.json SPB maturation|SPB organization|spindle pole body maturation|spindle pole body organisation|spindle pole body organization and biogenesis http://purl.obolibrary.org/obo/GO_0051300 GO:0002337 biolink:BiologicalProcess B-1a B cell differentiation The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors. go.json B-1a B cell development|B-1a B lymphocyte differentiation|B-1a B-cell differentiation|B-1a B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002337 GO:0002338 biolink:BiologicalProcess B-1b B cell differentiation The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5. go.json B-1b B cell development|B-1b B lymphocyte differentiation|B-1b B-cell differentiation|B-1b B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002338 GO:0051301 biolink:BiologicalProcess cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. Wikipedia:Cell_division go.json http://purl.obolibrary.org/obo/GO_0051301 goslim_chembl|goslim_drosophila|goslim_pir GO:0051306 biolink:BiologicalProcess mitotic sister chromatid separation The process in which sister chromatids are physically detached from each other during mitosis. go.json chromosome separation during mitosis|mitotic chromosome separation|mitotic sister chromatid resolution|sister chromatid separation during mitosis http://purl.obolibrary.org/obo/GO_0051306 GO:0002331 biolink:BiologicalProcess pre-B cell allelic exclusion Expression of a single heavy chain allele during pre-B cell differentiation. go.json pre-B lymphocyte allelic exclusion http://purl.obolibrary.org/obo/GO_0002331 GO:0051307 biolink:BiologicalProcess meiotic chromosome separation The process in which chromosomes are physically detached from each other during meiosis. go.json chromosome separation during meiosis|meiotic chromosome resolution http://purl.obolibrary.org/obo/GO_0051307 GO:0002332 biolink:BiologicalProcess transitional stage B cell differentiation The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent. go.json transitional stage B cell development|transitional stage B lymphocyte differentiation|transitional stage B-cell differentiation|transitional stage B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002332 GO:0002333 biolink:BiologicalProcess transitional one stage B cell differentiation The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21. go.json T1 stage B cell differentiation|transitional one stage B cell development|transitional one stage B lymphocyte differentiation|transitional one stage B-cell differentiation|transitional one stage B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002333 GO:0051304 biolink:BiologicalProcess chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). go.json chromatid release|rDNA separation http://purl.obolibrary.org/obo/GO_0051304 GO:0002334 biolink:BiologicalProcess transitional two stage B cell differentiation The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21. go.json T2 stage B cell differentiation|transitional two stage B cell development|transitional two stage B lymphocyte differentiation|transitional two stage B-cell differentiation|transitional two stage B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002334 GO:0051305 biolink:BiologicalProcess chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes. go.json chromosome migration to spindle pole|chromosome movement|chromosome movement to spindle pole http://purl.obolibrary.org/obo/GO_0051305 GO:0051308 biolink:BiologicalProcess male meiosis chromosome separation The process in which paired chromosomes are physically detached from each other during male meiosis. go.json chromosome separation during male meiosis|male meiosis chromosome resolution http://purl.obolibrary.org/obo/GO_0051308 GO:0051309 biolink:BiologicalProcess female meiosis chromosome separation The process in which paired chromosomes are physically detached from each other during female meiosis. go.json chromosome separation during female meiosis|female meiosis chromosome resolution http://purl.obolibrary.org/obo/GO_0051309 GO:0002330 biolink:BiologicalProcess pre-B cell receptor expression The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell. go.json http://purl.obolibrary.org/obo/GO_0002330 GO:0016976 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016976 GO:0016977 biolink:MolecularActivity chitosanase activity Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan. EC:3.2.1.132|MetaCyc:3.2.1.132-RXN go.json chitosan N-acetylglucosaminohydrolase activity http://purl.obolibrary.org/obo/GO_0016977 GO:1905710 biolink:BiologicalProcess positive regulation of membrane permeability Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane. go.json http://purl.obolibrary.org/obo/GO_1905710 GO:0016978 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016978 GO:0016979 biolink:MolecularActivity lipoate-protein ligase activity Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP. EC:6.3.1.20|MetaCyc:RXN-13039|MetaCyc:RXN-8654|MetaCyc:RXN-8655|MetaCyc:RXN0-1141|RHEA:49288 go.json lipoate-protein ligase A activity|lipoate-protein ligase B activity|lipoate-protein ligase activity (lipoylation of glycine cleavage complex) http://purl.obolibrary.org/obo/GO_0016979 GO:1905711 biolink:BiologicalProcess response to phosphatidylethanolamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus. go.json response to PE|response to PtdEtn|response to phosphatidyl(amino)ethanols|response to phosphatidylethanolamines http://purl.obolibrary.org/obo/GO_1905711 GO:0016972 biolink:MolecularActivity thiol oxidase activity Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2. EC:1.8.3.2|MetaCyc:THIOL-OXIDASE-RXN|RHEA:17357|UM-BBD_reactionID:r1293 go.json sulfhydryl oxidase activity|thiol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016972 GO:1905712 biolink:BiologicalProcess cellular response to phosphatidylethanolamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus. go.json cellular response to PE|cellular response to PtdEtn|cellular response to phosphatidyl(amino)ethanols|cellular response to phosphatidylethanolamines http://purl.obolibrary.org/obo/GO_1905712 GO:1905713 biolink:BiologicalProcess obsolete mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium ion concentration OBSOLETE. Any mitochondrial calcium uptake that is involved in regulation of presynaptic cytosolic calcium ion concentration. go.json calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration|calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium levels|mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium levels True http://purl.obolibrary.org/obo/GO_1905713 GO:0016973 biolink:BiologicalProcess poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. go.json poly(A) mRNA export from nucleus|poly(A)+ mRNA export from cell nucleus|poly(A)+ mRNA export out of nucleus|poly(A)+ mRNA transport from nucleus to cytoplasm|poly(A)+ mRNA-nucleus export|polyadenylated mRNA export from nucleus http://purl.obolibrary.org/obo/GO_0016973 GO:1905714 biolink:BiologicalProcess obsolete mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium ion concentration OBSOLETE. Any mitochondrial calcium release that is involved in regulation of presynaptic cytosolic calcium ion concentration. go.json calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration|calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium levels|mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium levels True http://purl.obolibrary.org/obo/GO_1905714 GO:0016974 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016974 GO:1905715 biolink:BiologicalProcess regulation of cornification Any process that modulates the frequency, rate or extent of cornification. go.json http://purl.obolibrary.org/obo/GO_1905715 GO:0016975 biolink:MolecularActivity obsolete alpha-2 macroglobulin OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates. go.json alpha-2 macroglobulin True http://purl.obolibrary.org/obo/GO_0016975 GO:1905716 biolink:BiologicalProcess negative regulation of cornification Any process that stops, prevents or reduces the frequency, rate or extent of cornification. go.json down regulation of cornification|down-regulation of cornification|downregulation of cornification|inhibition of cornification http://purl.obolibrary.org/obo/GO_1905716 GO:1905717 biolink:BiologicalProcess positive regulation of cornification Any process that activates or increases the frequency, rate or extent of cornification. go.json activation of cornification|up regulation of cornification|up-regulation of cornification|upregulation of cornification http://purl.obolibrary.org/obo/GO_1905717 GO:1905718 biolink:CellularComponent obsolete mitotic spindle astral microtubule end OBSOLETE. Any microtubule end that is part of a mitotic spindle astral microtubule. go.json mitotic spindle astral microtubule tip True http://purl.obolibrary.org/obo/GO_1905718 GO:0016970 biolink:MolecularActivity obsolete hemocyanin OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods. go.json hemocyanin True http://purl.obolibrary.org/obo/GO_0016970 GO:1905719 biolink:BiologicalProcess protein localization to perinuclear region of cytoplasm A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm. go.json protein localisation in perinuclear region of cytoplasm|protein localisation to perinuclear region of cytoplasm|protein localization in perinuclear region of cytoplasm|protein localization to perinuclear cytoplasm http://purl.obolibrary.org/obo/GO_1905719 GO:0016971 biolink:MolecularActivity flavin-dependent sulfhydryl oxidase activity Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins. RHEA:59116 go.json flavin-linked sulfhydryl oxidase activity http://purl.obolibrary.org/obo/GO_0016971 GO:0002339 biolink:BiologicalProcess B cell selection The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival. go.json B lymphocyte selection|B-cell selection|B-lymphocyte selection http://purl.obolibrary.org/obo/GO_0002339 GO:0002302 biolink:BiologicalProcess CD8-positive, alpha-beta T cell differentiation involved in immune response The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. go.json CD8-positive, alpha-beta T cell differentiation during immune response|CD8-positive, alpha-beta T lymphocyte differentiation during immune response|CD8-positive, alpha-beta T-cell differentiation during immune response|CD8-positive, alpha-beta T-lymphocyte differentiation during immune response|CD8-positive, alpha-beta intraepithelial T cell development http://purl.obolibrary.org/obo/GO_0002302 GO:0051313 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051313 GO:0002303 biolink:BiologicalProcess gamma-delta T cell differentiation involved in immune response The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. go.json gamma-delta T cell development involved in immune response|gamma-delta T cell differentiation during immune response|gamma-delta T lymphocyte differentiation during immune response|gamma-delta T-cell differentiation during immune response|gamma-delta T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0002303 GO:0051314 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051314 GO:0002304 biolink:BiologicalProcess gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. go.json gamma-delta intraepithelial T cell development|gamma-delta intraepithelial T lymphocyte differentiation|gamma-delta intraepithelial T-cell differentiation|gamma-delta intraepithelial T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002304 GO:0051311 biolink:BiologicalProcess meiotic metaphase chromosome alignment A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during meiotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. go.json metaphase plate congression during meiosis http://purl.obolibrary.org/obo/GO_0051311 GO:0051312 biolink:BiologicalProcess obsolete chromosome decondensation OBSOLETE. The alteration of chromosome structure from the condensed form to a relaxed disperse form. go.json True http://purl.obolibrary.org/obo/GO_0051312 GO:0002305 biolink:BiologicalProcess CD8-positive, gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. go.json CD8-positive, gamma-delta intraepithelial T cell development|CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation|CD8-positive, gamma-delta intraepithelial T-cell differentiation|CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002305 GO:0051317 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051317 GO:0051318 biolink:BiologicalProcess G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. Wikipedia:G1_phase go.json http://purl.obolibrary.org/obo/GO_0051318 gocheck_do_not_annotate GO:0002300 biolink:BiologicalProcess CD8-positive, alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. go.json CD8-positive, alpha-beta intraepithelial T cell development|CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation|CD8-positive, alpha-beta intraepithelial T-cell differentiation|CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002300 GO:0051315 biolink:BiologicalProcess attachment of mitotic spindle microtubules to kinetochore The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis. go.json attachment of spindle microtubules to kinetochore during mitosis|attachment of spindle microtubules to kinetochore involved in mitosis|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|attachment of spindle microtubules to mitotic chromosome|mitotic bipolar attachment http://purl.obolibrary.org/obo/GO_0051315 GO:0002301 biolink:BiologicalProcess CD4-positive, alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. go.json CD4-positive, alpha-beta intraepithelial T cell development|CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation|CD4-positive, alpha-beta intraepithelial T-cell differentiation|CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002301 GO:0051316 biolink:BiologicalProcess attachment of meiotic spindle microtubules to kinetochore The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis. go.json attachment of spindle microtubules to kinetochore during meiosis|attachment of spindle microtubules to kinetochore during meiotic chromosome segregation|attachment of spindle microtubules to meiotic chromosome http://purl.obolibrary.org/obo/GO_0051316 GO:2000786 biolink:BiologicalProcess positive regulation of autophagosome assembly Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly. go.json positive regulation of PAS formation|positive regulation of autophagic vacuole assembly|positive regulation of autophagic vacuole formation|positive regulation of autophagosome biosynthesis|positive regulation of autophagosome formation http://purl.obolibrary.org/obo/GO_2000786 GO:2000787 biolink:BiologicalProcess regulation of venous endothelial cell fate commitment Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment. go.json http://purl.obolibrary.org/obo/GO_2000787 GO:2000788 biolink:BiologicalProcess negative regulation of venous endothelial cell fate commitment Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment. go.json http://purl.obolibrary.org/obo/GO_2000788 GO:0051319 biolink:BiologicalProcess G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). Wikipedia:G2_phase go.json http://purl.obolibrary.org/obo/GO_0051319 gocheck_do_not_annotate GO:2000789 biolink:BiologicalProcess positive regulation of venous endothelial cell fate commitment Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment. go.json http://purl.obolibrary.org/obo/GO_2000789 GO:0016947 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016947 GO:0016948 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016948 GO:0016949 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016949 GO:0016943 biolink:MolecularActivity obsolete RNA polymerase I transcription elongation factor activity OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation. go.json Pol I transcription elongation factor activity|RNA polymerase I transcription elongation factor activity True http://purl.obolibrary.org/obo/GO_0016943 GO:0016944 biolink:MolecularActivity obsolete RNA polymerase II transcription elongation factor activity OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation. go.json Pol II transcription elongation factor activity|RNA polymerase II transcription elongation factor activity True http://purl.obolibrary.org/obo/GO_0016944 GO:1905720 biolink:CellularComponent cytoplasmic microtubule bundle Any microtubule bundle that is part of a cytoplasm. go.json microtubule bundle of cytoplasm|microtubule fascicle of cytoplasm http://purl.obolibrary.org/obo/GO_1905720 GO:1905721 biolink:CellularComponent mitotic spindle astral microtubule end Any microtubule end that is part of a mitotic spindle astral microtubule. go.json mitotic spindle astral microtubule tip http://purl.obolibrary.org/obo/GO_1905721 GO:0016945 biolink:MolecularActivity obsolete RNA polymerase III transcription elongation factor activity OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation. go.json Pol III transcription elongation factor activity|RNA polymerase III transcription elongation factor activity True http://purl.obolibrary.org/obo/GO_0016945 GO:2000780 biolink:BiologicalProcess negative regulation of double-strand break repair Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair. go.json http://purl.obolibrary.org/obo/GO_2000780 GO:0016946 biolink:MolecularActivity obsolete cathepsin F activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2. go.json cathepsin F activity True http://purl.obolibrary.org/obo/GO_0016946 GO:1905722 biolink:BiologicalProcess regulation of trypanothione biosynthetic process Any process that modulates the frequency, rate or extent of trypanothione biosynthetic process. go.json regulation of trypanothione anabolism|regulation of trypanothione biosynthesis|regulation of trypanothione formation|regulation of trypanothione synthesis http://purl.obolibrary.org/obo/GO_1905722 GO:2000781 biolink:BiologicalProcess positive regulation of double-strand break repair Any process that activates or increases the frequency, rate or extent of double-strand break repair. go.json http://purl.obolibrary.org/obo/GO_2000781 GO:1905723 biolink:BiologicalProcess negative regulation of trypanothione biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of trypanothione biosynthetic process. go.json down regulation of trypanothione anabolism|down regulation of trypanothione biosynthesis|down regulation of trypanothione biosynthetic process|down regulation of trypanothione formation|down regulation of trypanothione synthesis|down-regulation of trypanothione anabolism|down-regulation of trypanothione biosynthesis|down-regulation of trypanothione biosynthetic process|down-regulation of trypanothione formation|down-regulation of trypanothione synthesis|downregulation of trypanothione anabolism|downregulation of trypanothione biosynthesis|downregulation of trypanothione biosynthetic process|downregulation of trypanothione formation|downregulation of trypanothione synthesis|inhibition of trypanothione anabolism|inhibition of trypanothione biosynthesis|inhibition of trypanothione biosynthetic process|inhibition of trypanothione formation|inhibition of trypanothione synthesis|negative regulation of trypanothione anabolism|negative regulation of trypanothione biosynthesis|negative regulation of trypanothione formation|negative regulation of trypanothione synthesis http://purl.obolibrary.org/obo/GO_1905723 GO:2000782 biolink:BiologicalProcess regulation of establishment of cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of establishment of cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000782 GO:1905724 biolink:BiologicalProcess positive regulation of trypanothione biosynthetic process Any process that activates or increases the frequency, rate or extent of trypanothione biosynthetic process. go.json activation of trypanothione anabolism|activation of trypanothione biosynthesis|activation of trypanothione biosynthetic process|activation of trypanothione formation|activation of trypanothione synthesis|positive regulation of trypanothione anabolism|positive regulation of trypanothione biosynthesis|positive regulation of trypanothione formation|positive regulation of trypanothione synthesis|up regulation of trypanothione anabolism|up regulation of trypanothione biosynthesis|up regulation of trypanothione biosynthetic process|up regulation of trypanothione formation|up regulation of trypanothione synthesis|up-regulation of trypanothione anabolism|up-regulation of trypanothione biosynthesis|up-regulation of trypanothione biosynthetic process|up-regulation of trypanothione formation|up-regulation of trypanothione synthesis|upregulation of trypanothione anabolism|upregulation of trypanothione biosynthesis|upregulation of trypanothione biosynthetic process|upregulation of trypanothione formation|upregulation of trypanothione synthesis http://purl.obolibrary.org/obo/GO_1905724 GO:2000783 biolink:BiologicalProcess negative regulation of establishment of cell polarity regulating cell shape Any process that stops, prevents or reduces the frequency, rate or extent of establishment of cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000783 GO:0016940 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016940 GO:2000784 biolink:BiologicalProcess positive regulation of establishment of cell polarity regulating cell shape Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape. go.json http://purl.obolibrary.org/obo/GO_2000784 GO:0016941 biolink:MolecularActivity natriuretic peptide receptor activity Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0016941 GO:1905725 biolink:BiologicalProcess protein localization to microtubule end A process in which a protein is transported to, or maintained in, a location at a microtubule end. go.json protein localisation to microtubule end http://purl.obolibrary.org/obo/GO_1905725 GO:2000785 biolink:BiologicalProcess regulation of autophagosome assembly Any process that modulates the frequency, rate or extent of autophagosome assembly. go.json regulation of PAS formation|regulation of autophagic vacuole assembly|regulation of autophagic vacuole formation|regulation of autophagosome biosynthesis|regulation of autophagosome formation http://purl.obolibrary.org/obo/GO_2000785 GO:0016942 biolink:CellularComponent insulin-like growth factor binding protein complex A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. go.json IGF binding protein complex http://purl.obolibrary.org/obo/GO_0016942 goslim_pir GO:0002306 biolink:BiologicalProcess CD4-positive gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. go.json CD4-positive, gamma-delta intraepithelial T cell development|CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation|CD4-positive, gamma-delta intraepithelial T-cell differentiation|CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002306 GO:0051310 biolink:BiologicalProcess metaphase chromosome alignment A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. go.json chromosome congression http://purl.obolibrary.org/obo/GO_0051310 GO:0002307 biolink:BiologicalProcess CD8-positive, alpha-beta regulatory T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell. go.json CD8-positive, alpha-beta regulatory T cell development|CD8-positive, alpha-beta regulatory T lymphocyte differentiation|CD8-positive, alpha-beta regulatory T-cell differentiation|CD8-positive, alpha-beta regulatory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002307 GO:0002308 biolink:BiologicalProcess CD8-positive, alpha-beta cytotoxic T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell. go.json CD8-positive, alpha-beta cytotoxic T cell development|CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation|CD8-positive, alpha-beta cytotoxic T-cell differentiation|CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002308 GO:0002309 biolink:BiologicalProcess T cell proliferation involved in immune response The expansion of a T cell population by cell division as part of an immune response. go.json T cell proliferation during immune response|T lymphocyte proliferation during immune response|T-cell proliferation during immune response|T-lymphocyte proliferation during immune response http://purl.obolibrary.org/obo/GO_0002309 GO:0002313 biolink:BiologicalProcess mature B cell differentiation involved in immune response The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. go.json mature B cell development involved in immune response|mature B cell differentiation during immune response|mature B lymphocyte differentiation during immune response|mature B-cell differentiation during immune response|mature B-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0002313 GO:0051324 biolink:BiologicalProcess prophase The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Wikipedia:Prophase go.json http://purl.obolibrary.org/obo/GO_0051324 gocheck_do_not_annotate GO:0051325 biolink:BiologicalProcess interphase The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs. Wikipedia:Interphase go.json karyostasis|resting phase http://purl.obolibrary.org/obo/GO_0051325 gocheck_do_not_annotate GO:0002314 biolink:BiologicalProcess germinal center B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). go.json germinal center B cell development|germinal center B lymphocyte differentiation|germinal center B-cell differentiation|germinal center B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002314 GO:0002315 biolink:BiologicalProcess marginal zone B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). go.json marginal zone B cell development|marginal zone B lymphocyte differentiation|marginal zone B-cell differentiation|marginal zone B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002315 GO:0051322 biolink:BiologicalProcess anaphase The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle. Wikipedia:Anaphase go.json http://purl.obolibrary.org/obo/GO_0051322 gocheck_do_not_annotate GO:0002316 biolink:BiologicalProcess follicular B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region. go.json follicular B cell development|follicular B lymphocyte differentiation|follicular B-cell differentiation|follicular B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002316 GO:0051323 biolink:BiologicalProcess metaphase The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell. Wikipedia:Metaphase go.json http://purl.obolibrary.org/obo/GO_0051323 gocheck_do_not_annotate GO:0051328 biolink:BiologicalProcess meiotic interphase The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA. go.json interphase of meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051328 gocheck_do_not_annotate GO:0051329 biolink:BiologicalProcess mitotic interphase The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs. go.json interphase of mitotic cell cycle http://purl.obolibrary.org/obo/GO_0051329 gocheck_do_not_annotate GO:0002310 biolink:BiologicalProcess alpha-beta T cell proliferation involved in immune response The expansion of an alpha-beta T cell population by cell division as part of an immune response. go.json alpha-beta T cell proliferation during immune response|alpha-beta T lymphocyte proliferation during immune response|alpha-beta T-cell proliferation during immune response|alpha-beta T-lymphocyte proliferation during immune response http://purl.obolibrary.org/obo/GO_0002310 GO:0051326 biolink:BiologicalProcess telophase The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Wikipedia:Telophase go.json http://purl.obolibrary.org/obo/GO_0051326 gocheck_do_not_annotate GO:0002311 biolink:BiologicalProcess gamma-delta T cell proliferation involved in immune response The expansion of a gamma-delta T cell population by cell division as part of an immune response. go.json gamma-delta T cell proliferation during immune response|gamma-delta T lymphocyte proliferation during immune response|gamma-delta T-cell proliferation during immune response|gamma-delta T-lymphocyte proliferation during immune response http://purl.obolibrary.org/obo/GO_0002311 GO:0002312 biolink:BiologicalProcess B cell activation involved in immune response The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json B cell activation during immune response|B lymphocyte activation during immune response|B-cell activation during immune response|B-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002312 GO:0051327 biolink:BiologicalProcess meiotic M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle. go.json M phase of meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051327 gocheck_do_not_annotate GO:2000797 biolink:BiologicalProcess regulation of amniotic stem cell differentiation Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000797 GO:2000798 biolink:BiologicalProcess negative regulation of amniotic stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000798 GO:2000799 biolink:BiologicalProcess positive regulation of amniotic stem cell differentiation Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2000799 GO:0016958 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016958 GO:0016959 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016959 GO:0016954 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016954 GO:2000790 biolink:BiologicalProcess regulation of mesenchymal cell proliferation involved in lung development Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. go.json http://purl.obolibrary.org/obo/GO_2000790 GO:0016955 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016955 GO:2000791 biolink:BiologicalProcess negative regulation of mesenchymal cell proliferation involved in lung development Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. go.json http://purl.obolibrary.org/obo/GO_2000791 GO:0016956 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016956 GO:0016957 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016957 GO:2000792 biolink:BiologicalProcess positive regulation of mesenchymal cell proliferation involved in lung development Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. go.json http://purl.obolibrary.org/obo/GO_2000792 GO:2000793 biolink:BiologicalProcess cell proliferation involved in heart valve development Any cell proliferation that is involved in heart valve development. go.json cell proliferation of cardiac valve development|cell proliferation of heart valve development http://purl.obolibrary.org/obo/GO_2000793 GO:0016950 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016950 GO:1905735 biolink:BiologicalProcess regulation of L-proline import across plasma membrane Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905735 GO:2000794 biolink:BiologicalProcess regulation of epithelial cell proliferation involved in lung morphogenesis Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000794 GO:0016951 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016951 GO:2000795 biolink:BiologicalProcess negative regulation of epithelial cell proliferation involved in lung morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2000795 GO:1905736 biolink:BiologicalProcess negative regulation of L-proline import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905736 GO:0016952 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016952 GO:2000796 biolink:BiologicalProcess Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment Any Notch signaling pathway that is involved in negative regulation of venous endothelial cell fate commitment. go.json N signaling pathway involved in negative regulation of venous endothelial cell fate commitment|Notch receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment|Notch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment|Notch signalling pathway involved in negative regulation of venous endothelial cell fate commitment|Notch-receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment|Notch-receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment http://purl.obolibrary.org/obo/GO_2000796 GO:1905737 biolink:BiologicalProcess positive regulation of L-proline import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905737 GO:0016953 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016953 GO:0051320 biolink:BiologicalProcess S phase The cell cycle phase, following G1, during which DNA synthesis takes place. Wikipedia:S_phase go.json S-phase http://purl.obolibrary.org/obo/GO_0051320 gocheck_do_not_annotate GO:0002317 biolink:BiologicalProcess plasma cell differentiation The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. go.json plasma cell development http://purl.obolibrary.org/obo/GO_0002317 GO:0051321 biolink:BiologicalProcess meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. Wikipedia:Meiosis go.json meiosis http://purl.obolibrary.org/obo/GO_0051321 goslim_drosophila|goslim_yeast GO:0002318 biolink:BiologicalProcess myeloid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. go.json http://purl.obolibrary.org/obo/GO_0002318 GO:0002319 biolink:BiologicalProcess memory B cell differentiation The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody. go.json memory B cell development|memory B lymphocyte differentiation|memory B-cell differentiation|memory B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002319 GO:0051335 biolink:BiologicalProcess meiosis II nuclear membrane reassembly The reformation of the nuclear membrane during meiosis II. go.json meiosis II nuclear envelope reassembly http://purl.obolibrary.org/obo/GO_0051335 GO:0075302 biolink:BiologicalProcess regulation of basidiospore formation Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes. go.json http://purl.obolibrary.org/obo/GO_0075302 GO:0075303 biolink:BiologicalProcess positive regulation of basidiospore formation Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes. go.json http://purl.obolibrary.org/obo/GO_0075303 GO:0051336 biolink:BiologicalProcess regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. go.json hydrolase regulator http://purl.obolibrary.org/obo/GO_0051336 gocheck_do_not_annotate GO:0075304 biolink:BiologicalProcess negative regulation of basidiospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes. go.json http://purl.obolibrary.org/obo/GO_0075304 GO:0051333 biolink:BiologicalProcess meiotic nuclear membrane reassembly The cell cycle process in which the reformation of the nuclear membranes during meiosis occurs. go.json meiotic nuclear envelope reassembly http://purl.obolibrary.org/obo/GO_0051333 GO:0075305 biolink:BiologicalProcess obsolete modulation of growth or development of symbiont on or near host OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism. go.json modulation of growth or development of symbiont on or near host|modulation of growth or development of symbiont on or near host surface True http://purl.obolibrary.org/obo/GO_0075305 GO:0051334 biolink:BiologicalProcess meiosis I nuclear membrane reassembly The reformation of the nuclear membranes during meiosis I. go.json meiosis I nuclear envelope reassembly http://purl.obolibrary.org/obo/GO_0051334 GO:0075306 biolink:BiologicalProcess regulation of conidium formation Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. go.json http://purl.obolibrary.org/obo/GO_0075306 GO:0051339 biolink:BiologicalProcess regulation of lyase activity Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. go.json lyase regulator http://purl.obolibrary.org/obo/GO_0051339 gocheck_do_not_annotate GO:0075307 biolink:BiologicalProcess positive regulation of conidium formation Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. go.json http://purl.obolibrary.org/obo/GO_0075307 GO:0051337 biolink:BiologicalProcess amitosis Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation. go.json Remak nuclear division|direct nuclear division http://purl.obolibrary.org/obo/GO_0051337 GO:0075308 biolink:BiologicalProcess negative regulation of conidium formation Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. go.json http://purl.obolibrary.org/obo/GO_0075308 GO:0075309 biolink:BiologicalProcess obsolete negative regulation of growth or development of symbiont on or near host surface OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism. go.json negative regulation of growth or development of symbiont on or near host surface True http://purl.obolibrary.org/obo/GO_0075309 GO:0051338 biolink:BiologicalProcess regulation of transferase activity Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. go.json transferase regulator http://purl.obolibrary.org/obo/GO_0051338 gocheck_do_not_annotate|gocheck_do_not_manually_annotate GO:0016929 biolink:MolecularActivity deSUMOylase activity An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated. go.json SUMO-specific isopeptidase activity|SUMO-specific protease activity|SUSP|ULP http://purl.obolibrary.org/obo/GO_0016929 GO:0016925 biolink:BiologicalProcess protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. Wikipedia:SUMO_protein go.json SUMO-protein conjugation|Smt3-protein conjugation|Smt3p-protein conjugation|protein sumolation|small ubiquitin-related protein 1 conjugation|sumoylation http://purl.obolibrary.org/obo/GO_0016925 GO:0016926 biolink:BiologicalProcess protein desumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. go.json desumoylation|protein desumolation http://purl.obolibrary.org/obo/GO_0016926 GO:0016927 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016927 GO:1905750 biolink:BiologicalProcess negative regulation of endosome to plasma membrane protein transport Any process that stops, prevents or reduces the frequency, rate or extent of endosome to plasma membrane protein transport. go.json down regulation of endosome to plasma membrane protein transport|down-regulation of endosome to plasma membrane protein transport|downregulation of endosome to plasma membrane protein transport|inhibition of endosome to plasma membrane protein transport http://purl.obolibrary.org/obo/GO_1905750 GO:1905751 biolink:BiologicalProcess positive regulation of endosome to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport. go.json activation of endosome to plasma membrane protein transport|up regulation of endosome to plasma membrane protein transport|up-regulation of endosome to plasma membrane protein transport|upregulation of endosome to plasma membrane protein transport http://purl.obolibrary.org/obo/GO_1905751 GO:0016928 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016928 GO:0016921 biolink:MolecularActivity obsolete pyroglutamyl-peptidase II activity OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides. EC:3.4.19.6|MetaCyc:3.4.19.6-RXN go.json PAP-II activity|TRH-DE activity|TRH-degrading ectoenzyme activity|TRH-specific aminopeptidase activity|pyroglutamate aminopeptidase II|pyroglutamyl aminopeptidase II activity|pyroglutamyl peptidase II|pyroglutamyl-peptidase II activity|thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity|thyroliberinase activity|thyrotropin-releasing factor pyroglutamate aminopeptidase activity|thyrotropin-releasing hormone degrading ectoenzyme activity|thyrotropin-releasing hormone-degrading peptidase activity|thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0016921 GO:1905741 biolink:BiologicalProcess calcium export from the mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration Any mitochondrial calcium release that is involved in positive regulation of presynaptic cytosolic calcium concentration. go.json calcium ion transmembrane export from mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration|mitochondrial calcium release involved in positive regulation of presynaptic cytosolic calcium concentration http://purl.obolibrary.org/obo/GO_1905741 GO:0016922 biolink:MolecularActivity nuclear receptor binding Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. go.json ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor interactor activity|nuclear hormone receptor binding|steroid hormone receptor binding http://purl.obolibrary.org/obo/GO_0016922 GO:1905742 biolink:CellularComponent Ras guanyl-nucleotide exchange factor complex A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity. go.json http://purl.obolibrary.org/obo/GO_1905742 GO:0016923 biolink:MolecularActivity obsolete ligand-dependent thyroid hormone receptor interactor activity OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor. go.json TRIP4|ligand-dependent thyroid hormone receptor interactor activity True http://purl.obolibrary.org/obo/GO_0016923 GO:1905743 biolink:BiologicalProcess calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration. go.json calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration|mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration http://purl.obolibrary.org/obo/GO_1905743 goslim_synapse GO:1905744 biolink:BiologicalProcess regulation of mRNA cis splicing, via spliceosome Any process that modulates the frequency, rate or extent of mRNA cis splicing, via spliceosome. go.json regulation of nuclear mRNA cis splicing, via U2-type spliceosome|regulation of nuclear mRNA cis splicing, via spliceosome|regulation of splicing http://purl.obolibrary.org/obo/GO_1905744 GO:0016924 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016924 GO:1905745 biolink:BiologicalProcess negative regulation of mRNA cis splicing, via spliceosome Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cis splicing, via spliceosome. go.json http://purl.obolibrary.org/obo/GO_1905745 GO:1905746 biolink:BiologicalProcess positive regulation of mRNA cis splicing, via spliceosome Any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome. go.json http://purl.obolibrary.org/obo/GO_1905746 GO:1905747 biolink:BiologicalProcess negative regulation of saliva secretion Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion. go.json down regulation of saliva secretion|down regulation of salivation|down-regulation of saliva secretion|down-regulation of salivation|downregulation of saliva secretion|downregulation of salivation|inhibition of saliva secretion|inhibition of salivation|negative regulation of salivation http://purl.obolibrary.org/obo/GO_1905747 GO:0016920 biolink:MolecularActivity pyroglutamyl-peptidase activity Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0016920 GO:1905748 biolink:BiologicalProcess hard palate morphogenesis The developmental process by which a hard palate is generated and organized. go.json palatum durum morphogenesis http://purl.obolibrary.org/obo/GO_1905748 GO:1905749 biolink:BiologicalProcess regulation of endosome to plasma membrane protein transport Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport. go.json http://purl.obolibrary.org/obo/GO_1905749 GO:0051331 biolink:BiologicalProcess meiotic G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis. go.json G2 phase of meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051331 gocheck_do_not_annotate GO:0051332 biolink:BiologicalProcess meiotic S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle. go.json S phase of meiotic cell cycle|S-phase of meiotic cell cycle|premeiotic S-phase http://purl.obolibrary.org/obo/GO_0051332 gocheck_do_not_annotate GO:0075300 biolink:BiologicalProcess negative regulation of zygospore formation Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase. go.json http://purl.obolibrary.org/obo/GO_0075300 GO:0075301 biolink:BiologicalProcess obsolete cell differentiation involved in spore germination OBSOLETE. The process in which a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth. go.json True http://purl.obolibrary.org/obo/GO_0075301 GO:0051330 biolink:BiologicalProcess meiotic G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis. go.json G1 phase of meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051330 gocheck_do_not_annotate GO:0051346 biolink:BiologicalProcess negative regulation of hydrolase activity Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. go.json down regulation of hydrolase activity|down-regulation of hydrolase activity|downregulation of hydrolase activity|hydrolase inhibitor|inhibition of hydrolase activity http://purl.obolibrary.org/obo/GO_0051346 gocheck_do_not_annotate GO:0051347 biolink:BiologicalProcess positive regulation of transferase activity Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. go.json activation of transferase activity|stimulation of transferase activity|transferase activator|up regulation of transferase activity|up-regulation of transferase activity|upregulation of transferase activity http://purl.obolibrary.org/obo/GO_0051347 gocheck_do_not_annotate|gocheck_do_not_manually_annotate GO:0051344 biolink:BiologicalProcess negative regulation of cyclic-nucleotide phosphodiesterase activity Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. go.json 3',5' cyclic nucleotide phosphodiesterase inhibitor|3',5'-cyclic-AMP phosphodiesterase inhibitor|cAMP phosphodiesterase inhibitor|down regulation of cyclic nucleotide phosphodiesterase activity|down-regulation of cyclic nucleotide phosphodiesterase activity|downregulation of cyclic nucleotide phosphodiesterase activity|inhibition of cyclic nucleotide phosphodiesterase activity|negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity|negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity|negative regulation of cAMP phosphodiesterase activity|negative regulation of cGMP phosphodiesterase activity|negative regulation of cyclic nucleotide phosphodiesterase activity|phosphodiesterase inhibitor http://purl.obolibrary.org/obo/GO_0051344 gocheck_do_not_annotate GO:0051345 biolink:BiologicalProcess positive regulation of hydrolase activity Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. go.json activation of hydrolase activity|hydrolase activator|stimulation of hydrolase activity|up regulation of hydrolase activity|up-regulation of hydrolase activity|upregulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0051345 gocheck_do_not_annotate GO:0051348 biolink:BiologicalProcess negative regulation of transferase activity Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. go.json down regulation of transferase activity|down-regulation of transferase activity|downregulation of transferase activity|inhibition of transferase activity|transferase inhibitor http://purl.obolibrary.org/obo/GO_0051348 gocheck_do_not_annotate|gocheck_do_not_manually_annotate GO:0051349 biolink:BiologicalProcess positive regulation of lyase activity Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. go.json activation of lyase activity|lyase activator|stimulation of lyase activity|up regulation of lyase activity|up-regulation of lyase activity|upregulation of lyase activity http://purl.obolibrary.org/obo/GO_0051349 gocheck_do_not_annotate GO:0016936 biolink:MolecularActivity galactoside binding Binding to a glycoside in which the sugar group is galactose. go.json http://purl.obolibrary.org/obo/GO_0016936 goslim_chembl GO:0016937 biolink:MolecularActivity short-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short chain fatty acid residue. EC:1.3.8.1|RHEA:47196 go.json http://purl.obolibrary.org/obo/GO_0016937 GO:1905760 biolink:CellularComponent post-anaphase array microtubule end Any microtubule end that is part of a post-anaphase array microtubule. go.json microtubule end of microtubule of PAA|microtubule end of microtubule of post-anaphase array|microtubule end of microtubule of post-anaphase microtubule array|microtubule end of microtubuli of PAA|microtubule end of microtubuli of post-anaphase array|microtubule end of microtubuli of post-anaphase microtubule array|microtubule end of microtubulus of PAA|microtubule end of microtubulus of post-anaphase array|microtubule end of microtubulus of post-anaphase microtubule array|microtubule end of neurotubule of PAA|microtubule end of neurotubule of post-anaphase array|microtubule end of neurotubule of post-anaphase microtubule array|microtubule end of post-anaphase array microtubule http://purl.obolibrary.org/obo/GO_1905760 GO:1905761 biolink:MolecularActivity SCF ubiquitin ligase complex binding Binding to a SCF ubiquitin ligase complex. go.json CDL1 complex binding|CRL1 complex binding|Cul1-RING ubiquitin ligase complex binding|SCF complex binding|SCF complex substrate recognition subunit binding|Skp1/Cul1/F-box protein complex binding|cullin-RING ligase 1 binding http://purl.obolibrary.org/obo/GO_1905761 GO:0016938 biolink:CellularComponent kinesin I complex A complex of two kinesin heavy chains and two kinesin light chains. go.json http://purl.obolibrary.org/obo/GO_0016938 GO:0016939 biolink:CellularComponent kinesin II complex A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes. go.json http://purl.obolibrary.org/obo/GO_0016939 GO:1905762 biolink:MolecularActivity CCR4-NOT complex binding Binding to a CCR4-NOT complex. go.json http://purl.obolibrary.org/obo/GO_1905762 GO:1905752 biolink:BiologicalProcess obsolete regulation of argininosuccinate synthase activity OBSOLETE. Any process that modulates the frequency, rate or extent of argininosuccinate synthase activity. go.json regulation of L-citrulline:L-aspartate ligase (AMP-forming)|regulation of arginine succinate synthetase activity|regulation of argininosuccinate synthetase activity|regulation of argininosuccinic acid synthetase activity|regulation of arginosuccinate synthetase activity|regulation of citrulline--aspartate ligase activity True http://purl.obolibrary.org/obo/GO_1905752 GO:0016932 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016932 GO:1905753 biolink:BiologicalProcess obsolete positive regulation of argininosuccinate synthase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of argininosuccinate synthase activity. go.json activation of L-citrulline:L-aspartate ligase (AMP-forming)|activation of arginine succinate synthetase activity|activation of argininosuccinate synthase activity|activation of argininosuccinate synthetase activity|activation of argininosuccinic acid synthetase activity|activation of arginosuccinate synthetase activity|activation of citrulline--aspartate ligase activity|positive regulation of L-citrulline:L-aspartate ligase (AMP-forming)|positive regulation of arginine succinate synthetase activity|positive regulation of argininosuccinate synthetase activity|positive regulation of argininosuccinic acid synthetase activity|positive regulation of arginosuccinate synthetase activity|positive regulation of citrulline--aspartate ligase activity|up regulation of L-citrulline:L-aspartate ligase (AMP-forming)|up regulation of arginine succinate synthetase activity|up regulation of argininosuccinate synthase activity|up regulation of argininosuccinate synthetase activity|up regulation of argininosuccinic acid synthetase activity|up regulation of arginosuccinate synthetase activity|up regulation of citrulline--aspartate ligase activity|up-regulation of L-citrulline:L-aspartate ligase (AMP-forming)|up-regulation of arginine succinate synthetase activity|up-regulation of argininosuccinate synthase activity|up-regulation of argininosuccinate synthetase activity|up-regulation of argininosuccinic acid synthetase activity|up-regulation of arginosuccinate synthetase activity|up-regulation of citrulline--aspartate ligase activity|upregulation of L-citrulline:L-aspartate ligase (AMP-forming)|upregulation of arginine succinate synthetase activity|upregulation of argininosuccinate synthase activity|upregulation of argininosuccinate synthetase activity|upregulation of argininosuccinic acid synthetase activity|upregulation of arginosuccinate synthetase activity|upregulation of citrulline--aspartate ligase activity True http://purl.obolibrary.org/obo/GO_1905753 GO:0016933 biolink:MolecularActivity extracellularly glycine-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. go.json extracellular-glycine-gated ion channel activity|glycine receptor http://purl.obolibrary.org/obo/GO_0016933 GO:0016934 biolink:MolecularActivity extracellularly glycine-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. Reactome:R-HSA-975389 go.json extracellular-glycine-gated chloride channel activity|glycine receptor|glycine-inhibited chloride channel activity http://purl.obolibrary.org/obo/GO_0016934 GO:1905754 biolink:CellularComponent ascospore-type prospore nucleus Any nucleus that is part of a ascospore-type prospore. go.json cell nucleus of ascospore-type prospore|nucleus of ascospore-type prospore http://purl.obolibrary.org/obo/GO_1905754 GO:0016935 biolink:CellularComponent glycine-gated chloride channel complex A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0016935 GO:1905755 biolink:BiologicalProcess protein localization to cytoplasmic microtubule A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. go.json protein localisation to cytoplasmic microtubule http://purl.obolibrary.org/obo/GO_1905755 GO:1905756 biolink:BiologicalProcess regulation of primary cell septum biogenesis Any process that modulates the frequency, rate or extent of primary cell septum biogenesis. go.json http://purl.obolibrary.org/obo/GO_1905756 GO:1905757 biolink:BiologicalProcess negative regulation of primary cell septum biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis. go.json http://purl.obolibrary.org/obo/GO_1905757 GO:1905758 biolink:BiologicalProcess positive regulation of primary cell septum biogenesis Any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis. go.json http://purl.obolibrary.org/obo/GO_1905758 GO:0016930 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016930 GO:1905759 biolink:CellularComponent post-anaphase array microtubule Any microtubule that is part of a post-anaphase microtubule array. go.json microtubule of PAA|microtubule of post-anaphase array|microtubule of post-anaphase microtubule array|microtubuli of PAA|microtubuli of post-anaphase array|microtubuli of post-anaphase microtubule array|microtubulus of PAA|microtubulus of post-anaphase array|microtubulus of post-anaphase microtubule array|neurotubule of PAA|neurotubule of post-anaphase array|neurotubule of post-anaphase microtubule array http://purl.obolibrary.org/obo/GO_1905759 GO:0016931 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016931 GO:0051342 biolink:BiologicalProcess regulation of cyclic-nucleotide phosphodiesterase activity Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. go.json 3',5' cyclic nucleotide phosphodiesterase regulator|3',5'-cyclic-AMP phosphodiesterase regulator|cAMP phosphodiesterase regulator|phosphodiesterase regulator|regulation of 3',5' cyclic nucleotide phosphodiesterase activity|regulation of 3',5'-cyclic-AMP phosphodiesterase activity|regulation of cAMP phosphodiesterase activity|regulation of cGMP phosphodiesterase activity|regulation of cyclic nucleotide phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0051342 gocheck_do_not_annotate GO:0051343 biolink:BiologicalProcess positive regulation of cyclic-nucleotide phosphodiesterase activity Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. go.json 3',5' cyclic nucleotide phosphodiesterase activator|3',5'-cyclic-AMP phosphodiesterase activator|activation of cyclic nucleotide phosphodiesterase activity|cAMP phosphodiesterase activator|phosphodiesterase activator|positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity|positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity|positive regulation of cAMP phosphodiesterase activity|positive regulation of cGMP phosphodiesterase activity|positive regulation of cyclic nucleotide phosphodiesterase activity|stimulation of cyclic nucleotide phosphodiesterase activity|up regulation of cyclic nucleotide phosphodiesterase activity|up-regulation of cyclic nucleotide phosphodiesterase activity|upregulation of cyclic nucleotide phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0051343 gocheck_do_not_annotate GO:0051340 biolink:BiologicalProcess regulation of ligase activity Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. go.json ligase regulator http://purl.obolibrary.org/obo/GO_0051340 gocheck_do_not_annotate GO:0051341 biolink:BiologicalProcess regulation of oxidoreductase activity Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. go.json oxidoreductase regulator http://purl.obolibrary.org/obo/GO_0051341 gocheck_do_not_annotate GO:0002386 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002386 GO:0002387 biolink:BiologicalProcess immune response in gut-associated lymphoid tissue Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules. go.json immune response in GALT http://purl.obolibrary.org/obo/GO_0002387 GO:0002388 biolink:BiologicalProcess immune response in Peyer's patch Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine. go.json http://purl.obolibrary.org/obo/GO_0002388 GO:0002389 biolink:BiologicalProcess tolerance induction in Peyer's patch Tolerance induction taking place in the Peyer's patches. go.json http://purl.obolibrary.org/obo/GO_0002389 GO:0002382 biolink:BiologicalProcess regulation of tissue kallikrein-kinin cascade Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade. go.json regulation of glandular kallikrein-kinin cascade http://purl.obolibrary.org/obo/GO_0002382 GO:0002383 biolink:BiologicalProcess immune response in brain or nervous system An immune response taking place in the brain or nervous system. go.json http://purl.obolibrary.org/obo/GO_0002383 GO:0002384 biolink:BiologicalProcess hepatic immune response An immune response taking place in the liver. go.json http://purl.obolibrary.org/obo/GO_0002384 GO:0002385 biolink:BiologicalProcess mucosal immune response An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. go.json immune response in MALT|immune response in mucosal-associated lymphoid tissue|immune response in urogenital tract http://purl.obolibrary.org/obo/GO_0002385 GO:0002380 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002380 GO:0002381 biolink:BiologicalProcess immunoglobulin production involved in immunoglobulin-mediated immune response The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. go.json antibody production during immune response|antibody secretion during immune response|immunoglobulin biosynthetic process involved in immune response|immunoglobulin production during immune response|immunoglobulin production involved in immune response|immunoglobulin production involved in immunoglobulin mediated immune response|immunoglobulin secretion involved in immune response http://purl.obolibrary.org/obo/GO_0002381 gocheck_do_not_annotate GO:0002397 biolink:BiologicalProcess MHC class I protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules. go.json http://purl.obolibrary.org/obo/GO_0002397 GO:0002398 biolink:BiologicalProcess MHC class Ib protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules. go.json http://purl.obolibrary.org/obo/GO_0002398 GO:0002399 biolink:BiologicalProcess MHC class II protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. go.json http://purl.obolibrary.org/obo/GO_0002399 GO:0002393 biolink:BiologicalProcess lysosomal enzyme production involved in inflammatory response The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels. go.json lysosomal enzyme production involved in acute inflammatory response|production of lysosomal enzymes involved in acute inflammatory response|production of lysosomal enzymes involved in inflammatory response http://purl.obolibrary.org/obo/GO_0002393 GO:0002394 biolink:BiologicalProcess tolerance induction in gut-associated lymphoid tissue Tolerance induction taking place in the gut-associated lymphoid tissue (GALT). go.json oral tolerance|tolerance induction in GALT http://purl.obolibrary.org/obo/GO_0002394 GO:0002395 biolink:BiologicalProcess immune response in nasopharyngeal-associated lymphoid tissue An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids. go.json immune response in NALT http://purl.obolibrary.org/obo/GO_0002395 GO:0002396 biolink:BiologicalProcess MHC protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002396 GO:0002390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002390 GO:0002391 biolink:BiologicalProcess platelet activating factor production involved in inflammatory response The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. go.json platelet activating factor production|platelet activating factor production involved in acute inflammatory response|platelet activating factor secretion|platelet activating factor secretion involved in acute inflammatory response|platelet activating factor secretion involved in inflammatory response http://purl.obolibrary.org/obo/GO_0002391 GO:0002392 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002392 GO:0002368 biolink:BiologicalProcess B cell cytokine production Any process that contributes to cytokine production by a B cell. go.json B lymphocyte cytokine production|B-cell cytokine production|B-lymphocyte cytokine production http://purl.obolibrary.org/obo/GO_0002368 gocheck_do_not_annotate GO:0002369 biolink:BiologicalProcess T cell cytokine production Any process that contributes to cytokine production by a T cell. go.json T lymphocyte cytokine production|T-cell cytokine production|T-lymphocyte cytokine production http://purl.obolibrary.org/obo/GO_0002369 gocheck_do_not_annotate GO:0002364 biolink:BiologicalProcess NK T cell lineage commitment The process in which a pro-T cell becomes committed to becoming an NK T cell. go.json NK T lymphocyte lineage commitment|NK T-cell lineage commitment|NK T-lymphocyte lineage commitment|natural killer T lymphocyte lineage commitment|natural killer T-cell lineage commitment|natural killer T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002364 GO:0002365 biolink:BiologicalProcess gamma-delta T cell lineage commitment The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell. go.json gamma-delta T lymphocyte lineage commitment|gamma-delta T-cell lineage commitment|gamma-delta T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002365 GO:0002366 biolink:BiologicalProcess leukocyte activation involved in immune response A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. go.json immune cell activation during immune response|leucocyte activation during immune response|leukocyte activation during immune response http://purl.obolibrary.org/obo/GO_0002366 GO:0002367 biolink:BiologicalProcess cytokine production involved in immune response The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. go.json cytokine biosynthetic process involved in immune response|cytokine production during immune response|cytokine secretion during immune response|cytokine secretion involved in immune response http://purl.obolibrary.org/obo/GO_0002367 gocheck_do_not_annotate GO:0002360 biolink:BiologicalProcess T cell lineage commitment The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. go.json T lymphocyte lineage commitment|T-cell lineage commitment|T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002360 GO:0002361 biolink:BiologicalProcess CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell. go.json CD4-positive, CD25-positive, alpha-beta regulatory T cell development|CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation|CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation|CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0002361 GO:0002362 biolink:BiologicalProcess CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell. go.json CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment|CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment|CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002362 GO:0002363 biolink:BiologicalProcess alpha-beta T cell lineage commitment The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell. go.json alpha-beta T lymphocyte lineage commitment|alpha-beta T-cell lineage commitment|alpha-beta T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0002363 GO:0002379 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002379 GO:0002375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002375 GO:0002376 biolink:BiologicalProcess immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. Wikipedia:Immune_system go.json http://purl.obolibrary.org/obo/GO_0002376 goslim_agr|goslim_chembl|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_pir GO:0002377 biolink:BiologicalProcess immunoglobulin production The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json antibody production|immunoglobulin biosynthetic process|immunoglobulin secretion http://purl.obolibrary.org/obo/GO_0002377 gocheck_do_not_annotate GO:0002378 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002378 GO:0002371 biolink:BiologicalProcess dendritic cell cytokine production Any process that contributes to cytokine production by a dendritic cell. go.json http://purl.obolibrary.org/obo/GO_0002371 gocheck_do_not_annotate GO:0002372 biolink:BiologicalProcess myeloid dendritic cell cytokine production Any process that contributes to cytokine production by a myeloid dendritic cell. go.json http://purl.obolibrary.org/obo/GO_0002372 gocheck_do_not_annotate GO:0002373 biolink:BiologicalProcess plasmacytoid dendritic cell cytokine production Any process that contributes to cytokine production by a plasmacytoid dendritic cell. go.json http://purl.obolibrary.org/obo/GO_0002373 gocheck_do_not_annotate GO:0002374 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002374 GO:0002370 biolink:BiologicalProcess natural killer cell cytokine production Any process that contributes to cytokine production by a natural killer cell. go.json NK cell cytokine production http://purl.obolibrary.org/obo/GO_0002370 gocheck_do_not_annotate GO:0110137 biolink:BiologicalProcess regulation of imaginal disc-derived leg joint morphogenesis Any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0110137 GO:0110138 biolink:BiologicalProcess positive regulation of imaginal disc-derived leg joint morphogenesis Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110138 GO:0110135 biolink:BiologicalProcess Norrin signaling pathway The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state. go.json http://purl.obolibrary.org/obo/GO_0110135 GO:0110136 biolink:BiologicalProcess protein-RNA complex remodeling The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex. go.json protein-RNA complex remodelling http://purl.obolibrary.org/obo/GO_0110136 GO:0110133 biolink:BiologicalProcess obsolete negative regulation of CRISPR-cas system OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a CRISPR-cas system. go.json True http://purl.obolibrary.org/obo/GO_0110133 GO:0110134 biolink:BiologicalProcess meiotic drive A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis. go.json http://purl.obolibrary.org/obo/GO_0110134 goslim_pombe GO:0110131 biolink:CellularComponent Aim21-Tda2 complex A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables. go.json Aim21/Tda2 complex http://purl.obolibrary.org/obo/GO_0110131 GO:0110132 biolink:BiologicalProcess obsolete regulation of CRISPR-cas system OBSOLETE. Any process that modulates the frequency, rate or extent of a CRISPR-cas system. go.json True http://purl.obolibrary.org/obo/GO_0110132 GO:0110130 biolink:MolecularActivity ribitol-5-phosphatase activity Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate. RHEA:47648 go.json http://purl.obolibrary.org/obo/GO_0110130 GO:0110139 biolink:BiologicalProcess negative regulation of imaginal disc-derived leg joint morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110139 GO:0110148 biolink:BiologicalProcess obsolete biomineralization OBSOLETE. The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products. Wikipedia:Biomineralization go.json biomineral formation|biomineralisation|mineralisation|mineralization True http://purl.obolibrary.org/obo/GO_0110148 GO:0110149 biolink:BiologicalProcess obsolete regulation of biomineralization OBSOLETE. Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. go.json regulation of biomineral formation|regulation of biomineralisation|regulation of mineralisation|regulation of mineralization True http://purl.obolibrary.org/obo/GO_0110149 GO:0110146 biolink:CellularComponent magnetosome membrane The lipid bilayer surrounding a magnetosome. go.json http://purl.obolibrary.org/obo/GO_0110146 GO:0110147 biolink:BiologicalProcess protein maturation by nickel ion transfer A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation. go.json http://purl.obolibrary.org/obo/GO_0110147 GO:0110144 biolink:CellularComponent obsolete magnetosome part OBSOLETE. Any constituent part of a magnetosome, a membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. go.json True http://purl.obolibrary.org/obo/GO_0110144 GO:0110145 biolink:CellularComponent magnetosome lumen The volume enclosed by the membrane of a magnetosome. go.json http://purl.obolibrary.org/obo/GO_0110145 GO:0110142 biolink:CellularComponent ubiquinone biosynthesis complex The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. go.json CoQ metabolon|Ubi complex http://purl.obolibrary.org/obo/GO_0110142 GO:0110143 biolink:CellularComponent magnetosome A membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. Magnetosomes form linear chains that align along the cellular motility axis at midcell and function in bacterial navigation along the Earth's magnetic field. They are formed by invagination of the cell inner membrane; in some species they remain connected to the inner membrane, in others they pinch off to form independent intracellular vesicles. go.json http://purl.obolibrary.org/obo/GO_0110143 GO:0110140 biolink:BiologicalProcess flagellum attachment zone organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species. go.json FAZ organization|flagellum attachment zone organisation http://purl.obolibrary.org/obo/GO_0110140 GO:0110141 biolink:BiologicalProcess L-glutamate import into mitochondrion The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix. go.json http://purl.obolibrary.org/obo/GO_0110141 GO:0110159 biolink:BiologicalProcess regulation of mitotic spindle formation (spindle phase one) Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). go.json http://purl.obolibrary.org/obo/GO_0110159 GO:0110157 biolink:CellularComponent reelin complex An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain. go.json http://purl.obolibrary.org/obo/GO_0110157 GO:0110158 biolink:CellularComponent calpain complex A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate. go.json M-calpain|mu-calpain http://purl.obolibrary.org/obo/GO_0110158 GO:0110155 biolink:BiologicalProcess NAD-cap decapping Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes. go.json http://purl.obolibrary.org/obo/GO_0110155 GO:0110156 biolink:BiologicalProcess methylguanosine-cap decapping Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA. go.json http://purl.obolibrary.org/obo/GO_0110156 GO:0110153 biolink:MolecularActivity RNA NAD-cap (NMN-forming) hydrolase activity Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+. RHEA:60876 go.json http://purl.obolibrary.org/obo/GO_0110153 GO:0110154 biolink:BiologicalProcess RNA decapping Cleavage of the 5'-cap of an RNA. go.json http://purl.obolibrary.org/obo/GO_0110154 GO:0110151 biolink:BiologicalProcess obsolete positive regulation of biomineralization OBSOLETE. Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. go.json positive regulation of biomineral formation|positive regulation of biomineralisation|positive regulation of mineralisation|positive regulation of mineralization True http://purl.obolibrary.org/obo/GO_0110151 GO:0110152 biolink:MolecularActivity RNA NAD-cap (NAD-forming) hydrolase activity Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+. RHEA:60880 go.json http://purl.obolibrary.org/obo/GO_0110152 GO:0110150 biolink:BiologicalProcess obsolete negative regulation of biomineralization OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. go.json negative regulation of biomineral formation|negative regulation of biomineralisation|negative regulation of mineralisation|negative regulation of mineralization True http://purl.obolibrary.org/obo/GO_0110150 GO:0110166 biolink:BiologicalProcess DNA synthesis involved in mitochondrial DNA replication Any DNA biosynthetic process that is involved in mitochondrial DNA replication. go.json DNA biosynthetic process involved in mitochondrial DNA replication http://purl.obolibrary.org/obo/GO_0110166 GO:0110164 biolink:BiologicalProcess positive regulation of mitotic spindle elongation (spindle phase three) Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three). go.json http://purl.obolibrary.org/obo/GO_0110164 GO:0110165 biolink:CellularComponent cellular anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. go.json http://purl.obolibrary.org/obo/GO_0110165 gocheck_do_not_annotate|goslim_pir GO:0110162 biolink:BiologicalProcess regulation of mitotic spindle elongation (spindle phase three) Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three). go.json http://purl.obolibrary.org/obo/GO_0110162 GO:0110163 biolink:BiologicalProcess negative regulation of mitotic spindle elongation (spindle phase three) Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three). go.json http://purl.obolibrary.org/obo/GO_0110163 GO:0110160 biolink:BiologicalProcess negative regulation of mitotic spindle formation (spindle phase one) Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). go.json http://purl.obolibrary.org/obo/GO_0110160 GO:0110161 biolink:BiologicalProcess positive regulation of mitotic spindle formation (spindle phase one) Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). go.json http://purl.obolibrary.org/obo/GO_0110161 GO:0110104 biolink:BiologicalProcess mRNA alternative polyadenylation The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals). go.json http://purl.obolibrary.org/obo/GO_0110104 GO:0110105 biolink:BiologicalProcess mRNA cleavage and polyadenylation specificity factor complex assembly The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex. go.json http://purl.obolibrary.org/obo/GO_0110105 GO:0110102 biolink:BiologicalProcess ribulose bisphosphate carboxylase complex assembly The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex. go.json RuBisCO assembly http://purl.obolibrary.org/obo/GO_0110102 GO:0110103 biolink:CellularComponent RNA polymerase II termination complex A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end. go.json TXT complex http://purl.obolibrary.org/obo/GO_0110103 GO:0110100 biolink:BiologicalProcess spindle pole body separation The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble. go.json http://purl.obolibrary.org/obo/GO_0110100 gocheck_do_not_manually_annotate GO:0110101 biolink:BiologicalProcess L-valine transmembrane import into vacuole The directed movement of L-valine into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0110101 GO:0110108 biolink:BiologicalProcess positive regulation of imaginal disc-derived wing vein specification Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification. go.json http://purl.obolibrary.org/obo/GO_0110108 GO:0110109 biolink:BiologicalProcess negative regulation of imaginal disc-derived wing vein specification Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification. go.json http://purl.obolibrary.org/obo/GO_0110109 GO:0110107 biolink:BiologicalProcess regulation of imaginal disc-derived wing vein specification Any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification. go.json http://purl.obolibrary.org/obo/GO_0110107 GO:0110115 biolink:CellularComponent Cdr2 medial cortical node complex A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase. go.json interphase cortical node|interphase node http://purl.obolibrary.org/obo/GO_0110115 GO:0110116 biolink:BiologicalProcess regulation of compound eye photoreceptor cell differentiation Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0110116 GO:0110113 biolink:BiologicalProcess positive regulation of lipid transporter activity Any process that increases the frequency, rate, or extent of lipid transporter activity. go.json http://purl.obolibrary.org/obo/GO_0110113 gocheck_do_not_annotate GO:0110114 biolink:BiologicalProcess negative regulation of lipid transporter activity Any process that decreases the frequency, rate, or extent of lipid transporter activity. go.json http://purl.obolibrary.org/obo/GO_0110114 gocheck_do_not_annotate GO:0110111 biolink:BiologicalProcess negative regulation of animal organ morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110111 GO:0110112 biolink:BiologicalProcess regulation of lipid transporter activity Any process that modulates the frequency, rate, or extent of lipid transporter activity. go.json http://purl.obolibrary.org/obo/GO_0110112 gocheck_do_not_annotate GO:0110110 biolink:BiologicalProcess positive regulation of animal organ morphogenesis Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0110110 GO:0110119 biolink:BiologicalProcess positive regulation of very-low-density lipoprotein particle clearance Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance. go.json http://purl.obolibrary.org/obo/GO_0110119 GO:0110117 biolink:BiologicalProcess positive regulation of compound eye photoreceptor cell differentiation Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0110117 GO:0110118 biolink:BiologicalProcess negative regulation of compound eye photoreceptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0110118 GO:0110126 biolink:BiologicalProcess phloem loading The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink. go.json http://purl.obolibrary.org/obo/GO_0110126 GO:0110127 biolink:BiologicalProcess phloem unloading The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues. go.json http://purl.obolibrary.org/obo/GO_0110127 GO:0110124 biolink:BiologicalProcess positive regulation of myotube cell migration Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration. go.json http://purl.obolibrary.org/obo/GO_0110124 GO:0110125 biolink:BiologicalProcess negative regulation of myotube cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration. go.json http://purl.obolibrary.org/obo/GO_0110125 GO:0110122 biolink:BiologicalProcess myotube cell migration The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. go.json http://purl.obolibrary.org/obo/GO_0110122 GO:0110123 biolink:BiologicalProcess regulation of myotube cell migration Any process that modulates the frequency, rate or extent of myotube cell migration. go.json http://purl.obolibrary.org/obo/GO_0110123 GO:0110120 biolink:BiologicalProcess gamma-tubulin complex localization to nuclear side of mitotic spindle pole body Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0110120 GO:0110121 biolink:BiologicalProcess gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0110121 GO:0110128 biolink:BiologicalProcess phloem sucrose unloading The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues. go.json http://purl.obolibrary.org/obo/GO_0110128 GO:0110129 biolink:CellularComponent obsolete SHREC2 complex OBSOLETE. A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2. go.json True http://purl.obolibrary.org/obo/GO_0110129 GO:0051478 biolink:BiologicalProcess mannosylglycerate metabolic process The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. go.json mannosylglycerate metabolism http://purl.obolibrary.org/obo/GO_0051478 GO:2000629 biolink:BiologicalProcess negative regulation of miRNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process. go.json negative regulation of microRNA metabolic process http://purl.obolibrary.org/obo/GO_2000629 GO:0002500 biolink:BiologicalProcess proteolysis within lysosome associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation. go.json lysosomal proteolysis associated with antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002500 GO:0051479 biolink:BiologicalProcess mannosylglycerate biosynthetic process The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. go.json mannosylglycerate anabolism|mannosylglycerate biosynthesis|mannosylglycerate formation|mannosylglycerate synthesis http://purl.obolibrary.org/obo/GO_0051479 GO:0002501 biolink:BiologicalProcess peptide antigen assembly with MHC protein complex The binding of a peptide to the antigen binding groove of an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002501 GO:0051476 biolink:BiologicalProcess phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system A phosphoenolpyruvate-dependent sugar phosphotransferase transport specific for mammosylglycerate. go.json mannosylglycerate transport http://purl.obolibrary.org/obo/GO_0051476 GO:0002502 biolink:BiologicalProcess peptide antigen assembly with MHC class I protein complex The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules. go.json http://purl.obolibrary.org/obo/GO_0002502 GO:0051477 biolink:MolecularActivity mannosylglycerate transmembrane transporter activity Enables the transfer of a mannosylglycerate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0051477 GO:0002503 biolink:BiologicalProcess peptide antigen assembly with MHC class II protein complex The binding of a peptide to the antigen binding groove of an MHC class II protein complex. go.json http://purl.obolibrary.org/obo/GO_0002503 GO:2000621 biolink:BiologicalProcess regulation of DNA replication termination Any process that modulates the frequency, rate or extent of DNA replication termination. go.json http://purl.obolibrary.org/obo/GO_2000621 GO:2000622 biolink:BiologicalProcess regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. go.json regulation of mRNA breakdown, nonsense-mediated decay|regulation of mRNA catabolic process, nonsense-mediated|regulation of mRNA catabolism, nonsense-mediated|regulation of mRNA degradation, nonsense-mediated decay|regulation of nonsense-mediated mRNA decay|regulation of nuclear mRNA catabolic process, nonsense-mediated decay http://purl.obolibrary.org/obo/GO_2000622 GO:2000623 biolink:BiologicalProcess negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. go.json negative regulation of mRNA breakdown, nonsense-mediated decay|negative regulation of mRNA catabolic process, nonsense-mediated|negative regulation of mRNA catabolism, nonsense-mediated|negative regulation of mRNA degradation, nonsense-mediated decay|negative regulation of nonsense-mediated mRNA decay|negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay http://purl.obolibrary.org/obo/GO_2000623 GO:2000624 biolink:BiologicalProcess positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. go.json positive regulation of mRNA breakdown, nonsense-mediated decay|positive regulation of mRNA catabolic process, nonsense-mediated|positive regulation of mRNA catabolism, nonsense-mediated|positive regulation of mRNA degradation, nonsense-mediated decay|positive regulation of nonsense-mediated mRNA decay|positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay http://purl.obolibrary.org/obo/GO_2000624 GO:2000625 biolink:BiologicalProcess regulation of miRNA catabolic process Any process that modulates the frequency, rate or extent of miRNA catabolic process. go.json regulation of microRNA catabolic process http://purl.obolibrary.org/obo/GO_2000625 GO:1905650 biolink:BiologicalProcess positive regulation of shell calcification Any process that activates or increases the frequency, rate or extent of shell calcification. go.json activation of shell calcification|up regulation of shell calcification|up-regulation of shell calcification|upregulation of shell calcification http://purl.obolibrary.org/obo/GO_1905650 GO:2000626 biolink:BiologicalProcess negative regulation of miRNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process. go.json negative regulation of microRNA catabolic process http://purl.obolibrary.org/obo/GO_2000626 GO:1905651 biolink:BiologicalProcess regulation of artery morphogenesis Any process that modulates the frequency, rate or extent of artery morphogenesis. go.json regulation of arterial morphogenesis|regulation of arteriogenesis http://purl.obolibrary.org/obo/GO_1905651 GO:2000627 biolink:BiologicalProcess positive regulation of miRNA catabolic process Any process that activates or increases the frequency, rate or extent of miRNA catabolic process. go.json positive regulation of microRNA catabolic process http://purl.obolibrary.org/obo/GO_2000627 GO:1905652 biolink:BiologicalProcess negative regulation of artery morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. go.json down regulation of arterial morphogenesis|down regulation of arteriogenesis|down regulation of artery morphogenesis|down-regulation of arterial morphogenesis|down-regulation of arteriogenesis|down-regulation of artery morphogenesis|downregulation of arterial morphogenesis|downregulation of arteriogenesis|downregulation of artery morphogenesis|inhibition of arterial morphogenesis|inhibition of arteriogenesis|inhibition of artery morphogenesis|negative regulation of arterial morphogenesis|negative regulation of arteriogenesis http://purl.obolibrary.org/obo/GO_1905652 GO:2000628 biolink:BiologicalProcess regulation of miRNA metabolic process Any process that modulates the frequency, rate or extent of miRNA metabolic process. go.json regulation of microRNA metabolic process http://purl.obolibrary.org/obo/GO_2000628 GO:1905642 biolink:BiologicalProcess negative regulation of DNA methylation Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation. go.json down regulation of DNA methylation|down-regulation of DNA methylation|downregulation of DNA methylation|inhibition of DNA methylation http://purl.obolibrary.org/obo/GO_1905642 GO:1905643 biolink:BiologicalProcess positive regulation of DNA methylation Any process that activates or increases the frequency, rate or extent of DNA methylation. go.json activation of DNA methylation|up regulation of DNA methylation|up-regulation of DNA methylation|upregulation of DNA methylation http://purl.obolibrary.org/obo/GO_1905643 GO:1905644 biolink:BiologicalProcess regulation of FACT complex assembly Any process that modulates the frequency, rate or extent of FACT complex assembly. go.json regulation of FACT complex formation|regulation of Facilitates chromatin transcription complex assembly|regulation of Facilitates chromatin transcription complex formation http://purl.obolibrary.org/obo/GO_1905644 GO:1905645 biolink:BiologicalProcess negative regulation of FACT complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of FACT complex assembly. go.json down regulation of FACT complex assembly|down regulation of FACT complex formation|down regulation of Facilitates chromatin transcription complex assembly|down regulation of Facilitates chromatin transcription complex formation|down-regulation of FACT complex assembly|down-regulation of FACT complex formation|down-regulation of Facilitates chromatin transcription complex assembly|down-regulation of Facilitates chromatin transcription complex formation|downregulation of FACT complex assembly|downregulation of FACT complex formation|downregulation of Facilitates chromatin transcription complex assembly|downregulation of Facilitates chromatin transcription complex formation|inhibition of FACT complex assembly|inhibition of FACT complex formation|inhibition of Facilitates chromatin transcription complex assembly|inhibition of Facilitates chromatin transcription complex formation|negative regulation of FACT complex formation|negative regulation of Facilitates chromatin transcription complex assembly|negative regulation of Facilitates chromatin transcription complex formation http://purl.obolibrary.org/obo/GO_1905645 GO:1905646 biolink:BiologicalProcess positive regulation of FACT complex assembly Any process that activates or increases the frequency, rate or extent of FACT complex assembly. go.json activation of FACT complex assembly|activation of FACT complex formation|activation of Facilitates chromatin transcription complex assembly|activation of Facilitates chromatin transcription complex formation|positive regulation of FACT complex formation|positive regulation of Facilitates chromatin transcription complex assembly|positive regulation of Facilitates chromatin transcription complex formation|up regulation of FACT complex assembly|up regulation of FACT complex formation|up regulation of Facilitates chromatin transcription complex assembly|up regulation of Facilitates chromatin transcription complex formation|up-regulation of FACT complex assembly|up-regulation of FACT complex formation|up-regulation of Facilitates chromatin transcription complex assembly|up-regulation of Facilitates chromatin transcription complex formation|upregulation of FACT complex assembly|upregulation of FACT complex formation|upregulation of Facilitates chromatin transcription complex assembly|upregulation of Facilitates chromatin transcription complex formation http://purl.obolibrary.org/obo/GO_1905646 GO:1905647 biolink:BiologicalProcess proline import across plasma membrane The directed movement of proline from outside of a cell into the cytoplasmic compartment. go.json proline import into cell http://purl.obolibrary.org/obo/GO_1905647 GO:1905648 biolink:BiologicalProcess regulation of shell calcification Any process that modulates the frequency, rate or extent of shell calcification. go.json http://purl.obolibrary.org/obo/GO_1905648 GO:2000620 biolink:BiologicalProcess positive regulation of histone H4-K16 acetylation Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation. go.json positive regulation of histone H4 acetylation at K16 http://purl.obolibrary.org/obo/GO_2000620 GO:1905649 biolink:BiologicalProcess negative regulation of shell calcification Any process that stops, prevents or reduces the frequency, rate or extent of shell calcification. go.json down regulation of shell calcification|down-regulation of shell calcification|downregulation of shell calcification|inhibition of shell calcification http://purl.obolibrary.org/obo/GO_1905649 GO:0051470 biolink:BiologicalProcess ectoine transport The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria. RHEA:32791 go.json http://purl.obolibrary.org/obo/GO_0051470 GO:0002508 biolink:BiologicalProcess central tolerance induction Tolerance induction in the central lymphoid organs: the thymus and bone marrow. go.json http://purl.obolibrary.org/obo/GO_0002508 GO:0051471 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051471 GO:0002509 biolink:BiologicalProcess central tolerance induction to self antigen Tolerance induction in the central lymphoid organs directed at self antigens. go.json http://purl.obolibrary.org/obo/GO_0002509 GO:0051474 biolink:MolecularActivity glucosylglycerol transmembrane transporter activity Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. go.json http://purl.obolibrary.org/obo/GO_0051474 IAO:0000233 biolink:OntologyClass term tracker item IAO:0000233 go.json http://purl.obolibrary.org/obo/IAO_0000233 GO:0002504 biolink:BiologicalProcess antigen processing and presentation of peptide or polysaccharide antigen via MHC class II The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. go.json peptide or polysaccharide antigen processing and presentation of via MHC class II http://purl.obolibrary.org/obo/GO_0002504 GO:0051475 biolink:BiologicalProcess glucosylglycerol transmembrane transport The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, across a membrane. go.json glucosylglycerol transport http://purl.obolibrary.org/obo/GO_0051475 GO:0002505 biolink:BiologicalProcess antigen processing and presentation of polysaccharide antigen via MHC class II The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex. go.json polysaccharide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002505 GO:0051472 biolink:BiologicalProcess glucosylglycerol metabolic process The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. go.json glucosylglycerol metabolism http://purl.obolibrary.org/obo/GO_0051472 GO:0002506 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002506 GO:0051473 biolink:BiologicalProcess glucosylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. go.json glucosylglycerol anabolism|glucosylglycerol biosynthesis|glucosylglycerol formation|glucosylglycerol synthesis http://purl.obolibrary.org/obo/GO_0051473 GO:0002507 biolink:BiologicalProcess tolerance induction A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. go.json http://purl.obolibrary.org/obo/GO_0002507 GO:0051489 biolink:BiologicalProcess regulation of filopodium assembly Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. go.json regulation of filopodia biosynthesis|regulation of filopodia formation|regulation of filopodium formation http://purl.obolibrary.org/obo/GO_0051489 GO:0002511 biolink:BiologicalProcess central B cell receptor editing Receptor editing occurring in B cells in the bone marrow. go.json central B lymphocyte receptor editing|central B-cell receptor editing|central B-lymphocyte receptor editing http://purl.obolibrary.org/obo/GO_0002511 GO:0002512 biolink:BiologicalProcess central T cell tolerance induction Tolerance induction of T cells in the thymus. go.json central T lymphocyte tolerance induction|central T-cell tolerance induction|central T-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002512 GO:0002513 biolink:BiologicalProcess tolerance induction to self antigen Tolerance induction directed at self antigens. go.json http://purl.obolibrary.org/obo/GO_0002513 GO:0051487 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051487 GO:0002514 biolink:BiologicalProcess B cell tolerance induction A process involving any mechanism for tolerance induction in B cells. go.json B lymphocyte tolerance induction|B-cell tolerance induction|B-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002514 GO:0051488 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051488 GO:0002510 biolink:BiologicalProcess central B cell tolerance induction Tolerance induction of B cells in the bone marrow. go.json central B lymphocyte tolerance induction|central B-cell tolerance induction|central B-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002510 GO:2000632 biolink:BiologicalProcess negative regulation of pre-miRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing. go.json negative regulation of miRNA maturation|negative regulation of pre-microRNA processing http://purl.obolibrary.org/obo/GO_2000632 GO:2000633 biolink:BiologicalProcess positive regulation of pre-miRNA processing Any process that activates or increases the frequency, rate or extent of pre-microRNA processing. go.json positive regulation of miRNA maturation|positive regulation of pre-microRNA processing http://purl.obolibrary.org/obo/GO_2000633 GO:2000634 biolink:BiologicalProcess regulation of primary miRNA processing Any process that modulates the frequency, rate or extent of primary microRNA processing. go.json regulation of pri-miRNA processing|regulation of primary microRNA processing http://purl.obolibrary.org/obo/GO_2000634 GO:2000635 biolink:BiologicalProcess negative regulation of primary miRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing. go.json negative regulation of pri-miRNA processing|negative regulation of primary microRNA processing http://purl.obolibrary.org/obo/GO_2000635 GO:1905660 biolink:BiologicalProcess mitotic checkpoint complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitotic checkpoint complex. go.json MCC assembly|MCC formation|mitotic checkpoint complex formation http://purl.obolibrary.org/obo/GO_1905660 GO:2000636 biolink:BiologicalProcess positive regulation of primary miRNA processing Any process that activates or increases the frequency, rate or extent of primary microRNA processing. go.json positive regulation of pri-miRNA processing|positive regulation of primary microRNA processing http://purl.obolibrary.org/obo/GO_2000636 GO:1905661 biolink:BiologicalProcess regulation of telomerase RNA reverse transcriptase activity Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity. go.json regulation of telomerase, catalyst http://purl.obolibrary.org/obo/GO_1905661 gocheck_do_not_annotate GO:2000637 biolink:BiologicalProcess positive regulation of miRNA-mediated gene silencing A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA). go.json positive regulation of gene silencing by miRNA|positive regulation of gene silencing by microRNA|positive regulation of microRNA-mediated gene silencing http://purl.obolibrary.org/obo/GO_2000637 GO:1905662 biolink:BiologicalProcess negative regulation of telomerase RNA reverse transcriptase activity Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity. go.json down regulation of telomerase RNA reverse transcriptase activity|down regulation of telomerase, catalyst|down-regulation of telomerase RNA reverse transcriptase activity|down-regulation of telomerase, catalyst|downregulation of telomerase RNA reverse transcriptase activity|downregulation of telomerase, catalyst|inhibition of telomerase RNA reverse transcriptase activity|inhibition of telomerase, catalyst|negative regulation of telomerase, catalyst http://purl.obolibrary.org/obo/GO_1905662 gocheck_do_not_annotate GO:2000638 biolink:BiologicalProcess regulation of SREBP signaling pathway Any process that modulates the frequency, rate or extent of the SREBP signaling pathway. go.json regulation of SREBP-mediated signaling pathway|regulation of SREBP-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000638 GO:1905663 biolink:BiologicalProcess positive regulation of telomerase RNA reverse transcriptase activity Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity. go.json activation of telomerase RNA reverse transcriptase activity|activation of telomerase, catalyst|positive regulation of telomerase, catalyst|up regulation of telomerase RNA reverse transcriptase activity|up regulation of telomerase, catalyst|up-regulation of telomerase RNA reverse transcriptase activity|up-regulation of telomerase, catalyst|upregulation of telomerase RNA reverse transcriptase activity|upregulation of telomerase, catalyst http://purl.obolibrary.org/obo/GO_1905663 gocheck_do_not_annotate GO:2000639 biolink:BiologicalProcess negative regulation of SREBP signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway. go.json negative regulation of SREBP-mediated signaling pathway|negative regulation of SREBP-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000639 GO:1905653 biolink:BiologicalProcess positive regulation of artery morphogenesis Any process that activates or increases the frequency, rate or extent of artery morphogenesis. go.json activation of arterial morphogenesis|activation of arteriogenesis|activation of artery morphogenesis|positive regulation of arterial morphogenesis|positive regulation of arteriogenesis|up regulation of arterial morphogenesis|up regulation of arteriogenesis|up regulation of artery morphogenesis|up-regulation of arterial morphogenesis|up-regulation of arteriogenesis|up-regulation of artery morphogenesis|upregulation of arterial morphogenesis|upregulation of arteriogenesis|upregulation of artery morphogenesis http://purl.obolibrary.org/obo/GO_1905653 GO:1905654 biolink:BiologicalProcess regulation of artery smooth muscle contraction Any process that modulates the frequency, rate or extent of artery smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_1905654 GO:1905655 biolink:BiologicalProcess negative regulation of artery smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of artery smooth muscle contraction. go.json down regulation of artery smooth muscle contraction|down-regulation of artery smooth muscle contraction|downregulation of artery smooth muscle contraction|inhibition of artery smooth muscle contraction http://purl.obolibrary.org/obo/GO_1905655 GO:1905656 biolink:BiologicalProcess positive regulation of artery smooth muscle contraction Any process that activates or increases the frequency, rate or extent of artery smooth muscle contraction. go.json activation of artery smooth muscle contraction|up regulation of artery smooth muscle contraction|up-regulation of artery smooth muscle contraction|upregulation of artery smooth muscle contraction http://purl.obolibrary.org/obo/GO_1905656 GO:1905657 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905657 GO:1905658 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905658 GO:2000630 biolink:BiologicalProcess positive regulation of miRNA metabolic process Any process that activates or increases the frequency, rate or extent of miRNA metabolic process. go.json positive regulation of microRNA metabolic process http://purl.obolibrary.org/obo/GO_2000630 GO:1905659 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1905659 GO:2000631 biolink:BiologicalProcess regulation of pre-miRNA processing Any process that modulates the frequency, rate or extent of pre-microRNA processing. go.json regulation of miRNA maturation|regulation of pre-microRNA processing http://purl.obolibrary.org/obo/GO_2000631 GO:0002519 biolink:BiologicalProcess natural killer cell tolerance induction Tolerance induction of natural killer cells. go.json NK cell tolerance induction http://purl.obolibrary.org/obo/GO_0002519 GO:0051481 biolink:BiologicalProcess negative regulation of cytosolic calcium ion concentration Any process that decreases the concentration of calcium ions in the cytosol. go.json cytoplasmic calcium ion concentration reduction|cytosolic calcium ion concentration reduction|reduction of calcium ion concentration in cytoplasm|reduction of calcium ion concentration in cytosol|reduction of cytoplasmic calcium ion concentration|reduction of cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_0051481 GO:0051482 biolink:BiologicalProcess obsolete positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway OBSOLETE. Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. go.json elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway True http://purl.obolibrary.org/obo/GO_0051482 GO:0051480 biolink:BiologicalProcess regulation of cytosolic calcium ion concentration Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. go.json calcium ion homeostasis in cytoplasm|calcium ion homeostasis in cytosol|cytoplasmic calcium ion concentration regulation|cytoplasmic calcium ion homeostasis|cytosolic calcium ion concentration regulation|regulation of calcium ion concentration in cytoplasm|regulation of calcium ion concentration in cytosol|regulation of cytoplasmic calcium ion concentration http://purl.obolibrary.org/obo/GO_0051480 GO:0002515 biolink:BiologicalProcess B cell anergy Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction. go.json B lymphocyte anergy|B-cell anergy|B-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002515 GO:0051485 biolink:BiologicalProcess terpenoid biosynthetic process, mevalonate-dependent The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. go.json terpene biosynthesis, mevalonate-dependent|terpene biosynthetic process, mevalonate-dependent|terpenoid anabolism, mevalonate-dependent|terpenoid formation, mevalonate-dependent|terpenoid synthesis, mevalonate-dependent http://purl.obolibrary.org/obo/GO_0051485 GO:0002516 biolink:BiologicalProcess B cell deletion The apoptotic death of B cells which is part of B cell tolerance induction. go.json B lymphocyte deletion|B-cell deletion|B-lymphocyte deletion http://purl.obolibrary.org/obo/GO_0002516 GO:0051486 biolink:BiologicalProcess isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. go.json isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism|isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process|isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis|isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation|isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis http://purl.obolibrary.org/obo/GO_0051486 GO:0002517 biolink:BiologicalProcess T cell tolerance induction A process involving any mechanism for tolerance induction in T cells. go.json T lymphocyte tolerance induction|T-cell tolerance induction|T-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002517 GO:0051483 biolink:BiologicalProcess terpenoid biosynthetic process, mevalonate-independent The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate. go.json mevalonate-independent terpene biosynthesis|mevalonate-independent terpene biosynthetic process|mevalonate-independent terpenoid biosynthesis|mevalonate-independent terpenoid biosynthetic process|terpene biosynthesis, mevalonate-independent|terpene biosynthetic process, mevalonate-independent|terpenoid anabolism, mevalonate-independent|terpenoid formation, mevalonate-independent|terpenoid synthesis, mevalonate-independent http://purl.obolibrary.org/obo/GO_0051483 GO:0051484 biolink:BiologicalProcess isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. MetaCyc:NONMEVIPP-PWY go.json isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism|isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process|isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis|isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation|isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis http://purl.obolibrary.org/obo/GO_0051484 GO:0002518 biolink:BiologicalProcess lymphocyte chemotaxis across high endothelial venule The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002518 GO:0051498 biolink:MolecularActivity syn-copalyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate. EC:5.5.1.14|MetaCyc:RXN-8528|RHEA:25524 go.json diterpene cyclase activity http://purl.obolibrary.org/obo/GO_0051498 GO:0051499 biolink:MolecularActivity D-aminoacyl-tRNA deacylase activity Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA. EC:3.1.1.96|MetaCyc:RXN-15041|RHEA:13953 go.json http://purl.obolibrary.org/obo/GO_0051499 GO:2000643 biolink:BiologicalProcess positive regulation of early endosome to late endosome transport Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport. go.json http://purl.obolibrary.org/obo/GO_2000643 GO:2000644 biolink:BiologicalProcess regulation of receptor catabolic process Any process that modulates the frequency, rate or extent of receptor catabolic process. go.json regulation of receptor breakdown|regulation of receptor catabolism|regulation of receptor degradation http://purl.obolibrary.org/obo/GO_2000644 GO:2000645 biolink:BiologicalProcess negative regulation of receptor catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process. go.json negative regulation of receptor breakdown|negative regulation of receptor catabolism|negative regulation of receptor degradation http://purl.obolibrary.org/obo/GO_2000645 GO:2000646 biolink:BiologicalProcess positive regulation of receptor catabolic process Any process that activates or increases the frequency, rate or extent of receptor catabolic process. go.json positive regulation of receptor breakdown|positive regulation of receptor catabolism|positive regulation of receptor degradation http://purl.obolibrary.org/obo/GO_2000646 GO:1905670 biolink:BiologicalProcess TORC2 complex disassembly The disaggregation of a TORC2 complex into its constituent components. go.json TOR complex 2 disassembly|TORC 2 complex disassembly|TORC2 disassembly|mTORC2 disassembly|rapamycin and nutrient-insensitive TOR complex disassembly http://purl.obolibrary.org/obo/GO_1905670 GO:1905671 biolink:BiologicalProcess regulation of lysosome organization Any process that modulates the frequency, rate or extent of lysosome organization. go.json regulation of lysosome organisation|regulation of lysosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1905671 GO:2000647 biolink:BiologicalProcess negative regulation of stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000647 GO:1905672 biolink:BiologicalProcess negative regulation of lysosome organization Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization. go.json down regulation of lysosome organisation|down regulation of lysosome organization|down regulation of lysosome organization and biogenesis|down-regulation of lysosome organisation|down-regulation of lysosome organization|down-regulation of lysosome organization and biogenesis|downregulation of lysosome organisation|downregulation of lysosome organization|downregulation of lysosome organization and biogenesis|inhibition of lysosome organisation|inhibition of lysosome organization|inhibition of lysosome organization and biogenesis|negative regulation of lysosome organisation|negative regulation of lysosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1905672 GO:2000648 biolink:BiologicalProcess positive regulation of stem cell proliferation Any process that activates or increases the frequency, rate or extent of stem cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2000648 GO:1905673 biolink:BiologicalProcess positive regulation of lysosome organization Any process that activates or increases the frequency, rate or extent of lysosome organization. go.json activation of lysosome organisation|activation of lysosome organization|activation of lysosome organization and biogenesis|positive regulation of lysosome organisation|positive regulation of lysosome organization and biogenesis|up regulation of lysosome organisation|up regulation of lysosome organization|up regulation of lysosome organization and biogenesis|up-regulation of lysosome organisation|up-regulation of lysosome organization|up-regulation of lysosome organization and biogenesis|upregulation of lysosome organisation|upregulation of lysosome organization|upregulation of lysosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1905673 GO:2000649 biolink:BiologicalProcess regulation of sodium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. go.json regulation of sodium transporter activity http://purl.obolibrary.org/obo/GO_2000649 gocheck_do_not_annotate GO:1905674 biolink:BiologicalProcess regulation of adaptive immune memory response Any process that modulates the frequency, rate or extent of adaptive immune memory response. go.json http://purl.obolibrary.org/obo/GO_1905674 GO:1905664 biolink:BiologicalProcess regulation of calcium ion import across plasma membrane Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905664 GO:1905665 biolink:BiologicalProcess positive regulation of calcium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane. go.json activation of calcium ion import across plasma membrane|up regulation of calcium ion import across plasma membrane|up-regulation of calcium ion import across plasma membrane|upregulation of calcium ion import across plasma membrane http://purl.obolibrary.org/obo/GO_1905665 GO:1905666 biolink:BiologicalProcess regulation of protein localization to endosome Any process that modulates the frequency, rate or extent of protein localization to endosome. go.json regulation of protein localisation in endosome|regulation of protein localization in endosome http://purl.obolibrary.org/obo/GO_1905666 GO:1905667 biolink:BiologicalProcess negative regulation of protein localization to endosome Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endosome. go.json down regulation of protein localisation in endosome|down regulation of protein localization in endosome|down regulation of protein localization to endosome|down-regulation of protein localisation in endosome|down-regulation of protein localization in endosome|down-regulation of protein localization to endosome|downregulation of protein localisation in endosome|downregulation of protein localization in endosome|downregulation of protein localization to endosome|inhibition of protein localisation in endosome|inhibition of protein localization in endosome|inhibition of protein localization to endosome|negative regulation of protein localisation in endosome|negative regulation of protein localization in endosome http://purl.obolibrary.org/obo/GO_1905667 GO:1905668 biolink:BiologicalProcess positive regulation of protein localization to endosome Any process that activates or increases the frequency, rate or extent of protein localization to endosome. go.json activation of protein localisation in endosome|activation of protein localization in endosome|activation of protein localization to endosome|positive regulation of protein localisation in endosome|positive regulation of protein localization in endosome|up regulation of protein localisation in endosome|up regulation of protein localization in endosome|up regulation of protein localization to endosome|up-regulation of protein localisation in endosome|up-regulation of protein localization in endosome|up-regulation of protein localization to endosome|upregulation of protein localisation in endosome|upregulation of protein localization in endosome|upregulation of protein localization to endosome http://purl.obolibrary.org/obo/GO_1905668 GO:1905669 biolink:BiologicalProcess TORC1 complex assembly The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex. go.json TOR complex 1 assembly|TOR complex 1 formation|TORC 1 complex assembly|TORC 1 complex formation|TORC1 assembly|TORC1 complex formation|TORC1 formation|dTOR/dRaptor complex assembly|dTOR/dRaptor complex formation|dTORC1 assembly|dTORC1 formation|mTORC1 assembly|mTORC1 formation|nutrient sensitive complex assembly|nutrient sensitive complex formation|rapamycin and nutrient-sensitive TOR complex assembly|rapamycin and nutrient-sensitive TOR complex formation http://purl.obolibrary.org/obo/GO_1905669 GO:2000640 biolink:BiologicalProcess positive regulation of SREBP signaling pathway Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway. go.json positive regulation of SREBP-mediated signaling pathway|positive regulation of SREBP-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000640 GO:2000641 biolink:BiologicalProcess regulation of early endosome to late endosome transport Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. go.json http://purl.obolibrary.org/obo/GO_2000641 GO:2000642 biolink:BiologicalProcess negative regulation of early endosome to late endosome transport Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport. go.json http://purl.obolibrary.org/obo/GO_2000642 GO:0051492 biolink:BiologicalProcess regulation of stress fiber assembly Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. go.json regulation of stress fibre biosynthesis|regulation of stress fibre formation http://purl.obolibrary.org/obo/GO_0051492 GO:0051493 biolink:BiologicalProcess regulation of cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. go.json regulation of cytoskeleton organisation|regulation of cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0051493 GO:0051490 biolink:BiologicalProcess negative regulation of filopodium assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. go.json down regulation of filopodium formation|down-regulation of filopodium formation|downregulation of filopodium formation|inhibition of filopodium formation|negative regulation of filopodia biosynthesis|negative regulation of filopodia formation|negative regulation of filopodium formation http://purl.obolibrary.org/obo/GO_0051490 GO:0051491 biolink:BiologicalProcess positive regulation of filopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. go.json activation of filopodium formation|positive regulation of filopodia biosynthesis|positive regulation of filopodia formation|positive regulation of filopodium formation|stimulation of filopodium formation|up regulation of filopodium formation|up-regulation of filopodium formation|upregulation of filopodium formation http://purl.obolibrary.org/obo/GO_0051491 GO:0051496 biolink:BiologicalProcess positive regulation of stress fiber assembly Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. go.json activation of stress fiber formation|positive regulation of stress fibre biosynthesis|positive regulation of stress fibre formation|stimulation of stress fiber formation|up regulation of stress fiber formation|up-regulation of stress fiber formation|upregulation of stress fiber formation http://purl.obolibrary.org/obo/GO_0051496 GO:0051497 biolink:BiologicalProcess negative regulation of stress fiber assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. go.json down regulation of stress fiber formation|down-regulation of stress fiber formation|downregulation of stress fiber formation|inhibition of stress fiber formation|negative regulation of stress fibre biosynthesis|negative regulation of stress fibre formation http://purl.obolibrary.org/obo/GO_0051497 GO:0051494 biolink:BiologicalProcess negative regulation of cytoskeleton organization Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. go.json down regulation of cytoskeleton organization|down-regulation of cytoskeleton organization|downregulation of cytoskeleton organization|inhibition of cytoskeleton organization|negative regulation of cytoskeleton organisation|negative regulation of cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0051494 GO:0051495 biolink:BiologicalProcess positive regulation of cytoskeleton organization Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. go.json activation of cytoskeleton organization|positive regulation of cytoskeleton organisation|positive regulation of cytoskeleton organization and biogenesis|stimulation of cytoskeleton organization|up regulation of cytoskeleton organization|up-regulation of cytoskeleton organization|upregulation of cytoskeleton organization http://purl.obolibrary.org/obo/GO_0051495 GO:0099401 biolink:CellularComponent caveola bulb The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins. go.json caveola crater http://purl.obolibrary.org/obo/GO_0099401 GO:0099402 biolink:BiologicalProcess plant organ development Development of a plant organ, a multi-tissue plant structure that forms a functional unit. go.json development of a plant organ http://purl.obolibrary.org/obo/GO_0099402 GO:0099400 biolink:CellularComponent caveola neck A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it. go.json http://purl.obolibrary.org/obo/GO_0099400 GO:2000654 biolink:BiologicalProcess regulation of cellular response to testosterone stimulus Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_2000654 GO:2000655 biolink:BiologicalProcess negative regulation of cellular response to testosterone stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_2000655 GO:2000656 biolink:BiologicalProcess regulation of apolipoprotein binding Any process that modulates the frequency, rate or extent of apolipoprotein binding. go.json http://purl.obolibrary.org/obo/GO_2000656 gocheck_do_not_annotate GO:1905680 biolink:BiologicalProcess regulation of innate immunity memory response Any process that modulates the frequency, rate or extent of innate immunity memory response. go.json http://purl.obolibrary.org/obo/GO_1905680 GO:2000657 biolink:BiologicalProcess negative regulation of apolipoprotein binding Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding. go.json http://purl.obolibrary.org/obo/GO_2000657 gocheck_do_not_annotate GO:1905681 biolink:BiologicalProcess negative regulation of innate immunity memory response Any process that stops, prevents or reduces the frequency, rate or extent of innate immunity memory response. go.json down regulation of innate immunity memory response|down-regulation of innate immunity memory response|downregulation of innate immunity memory response|inhibition of innate immunity memory response http://purl.obolibrary.org/obo/GO_1905681 GO:2000658 biolink:BiologicalProcess positive regulation of apolipoprotein binding Any process that activates or increases the frequency, rate or extent of apolipoprotein binding. go.json http://purl.obolibrary.org/obo/GO_2000658 gocheck_do_not_annotate GO:1905682 biolink:BiologicalProcess positive regulation of innate immunity memory response Any process that activates or increases the frequency, rate or extent of innate immunity memory response. go.json activation of innate immunity memory response|up regulation of innate immunity memory response|up-regulation of innate immunity memory response|upregulation of innate immunity memory response http://purl.obolibrary.org/obo/GO_1905682 GO:2000659 biolink:BiologicalProcess regulation of interleukin-1-mediated signaling pathway Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway. go.json regulation of IL-1 alpha-mediated signaling pathway|regulation of IL-1 beta-mediated signaling pathway|regulation of IL-1-mediated signaling pathway|regulation of interleukin-1 alpha-mediated signaling pathway|regulation of interleukin-1 beta-mediated signaling pathway|regulation of interleukin-1-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000659 GO:1905683 biolink:BiologicalProcess obsolete peroxisome disassembly OBSOLETE. The disaggregation of a peroxisome into its constituent components. go.json True http://purl.obolibrary.org/obo/GO_1905683 GO:1905684 biolink:BiologicalProcess regulation of plasma membrane repair Any process that modulates the frequency, rate or extent of plasma membrane repair. go.json http://purl.obolibrary.org/obo/GO_1905684 GO:1905685 biolink:BiologicalProcess negative regulation of plasma membrane repair Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane repair. go.json down regulation of plasma membrane repair|down-regulation of plasma membrane repair|downregulation of plasma membrane repair|inhibition of plasma membrane repair http://purl.obolibrary.org/obo/GO_1905685 GO:1905675 biolink:BiologicalProcess negative regulation of adaptive immune memory response Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response. go.json down regulation of adaptive immune memory response|down-regulation of adaptive immune memory response|downregulation of adaptive immune memory response|inhibition of adaptive immune memory response http://purl.obolibrary.org/obo/GO_1905675 GO:1905676 biolink:BiologicalProcess positive regulation of adaptive immune memory response Any process that activates or increases the frequency, rate or extent of adaptive immune memory response. go.json activation of adaptive immune memory response|up regulation of adaptive immune memory response|up-regulation of adaptive immune memory response|upregulation of adaptive immune memory response http://purl.obolibrary.org/obo/GO_1905676 GO:1905677 biolink:BiologicalProcess regulation of adaptive immune effector response Any process that modulates the frequency, rate or extent of adaptive immune effector response. go.json http://purl.obolibrary.org/obo/GO_1905677 GO:1905678 biolink:BiologicalProcess negative regulation of adaptive immune effector response Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune effector response. go.json down regulation of adaptive immune effector response|down-regulation of adaptive immune effector response|downregulation of adaptive immune effector response|inhibition of adaptive immune effector response http://purl.obolibrary.org/obo/GO_1905678 GO:1905679 biolink:BiologicalProcess positive regulation of adaptive immune effector response Any process that activates or increases the frequency, rate or extent of adaptive immune effector response. go.json activation of adaptive immune effector response|up regulation of adaptive immune effector response|up-regulation of adaptive immune effector response|upregulation of adaptive immune effector response http://purl.obolibrary.org/obo/GO_1905679 GO:2000650 biolink:BiologicalProcess negative regulation of sodium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. go.json negative regulation of sodium transporter activity http://purl.obolibrary.org/obo/GO_2000650 gocheck_do_not_annotate GO:2000651 biolink:BiologicalProcess positive regulation of sodium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. go.json positive regulation of sodium transporter activity http://purl.obolibrary.org/obo/GO_2000651 gocheck_do_not_annotate GO:2000652 biolink:BiologicalProcess regulation of secondary cell wall biogenesis Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis. go.json regulation of cellulose and pectin-containing secondary cell wall biogenesis|regulation of plant-type secondary cell wall biogenesis|regulation of secondary cell wall anabolism|regulation of secondary cell wall biosynthetic process|regulation of secondary cell wall formation|regulation of secondary cell wall synthesis http://purl.obolibrary.org/obo/GO_2000652 GO:2000653 biolink:BiologicalProcess obsolete regulation of genetic imprinting OBSOLETE. Any process that modulates the frequency, rate or extent of genetic imprinting. go.json regulation of DNA imprinting True http://purl.obolibrary.org/obo/GO_2000653 GO:0099403 biolink:BiologicalProcess maintenance of mitotic sister chromatid cohesion, telomeric The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. go.json maintenance of mitotic sister chromatin cohesion at telomere|maintenance of sister chromatin cohesion at telomere at mitosis|maintenance of telomeric mitotic sister chromatin cohesion http://purl.obolibrary.org/obo/GO_0099403 GO:0099404 biolink:BiologicalProcess mitotic sister chromatid cohesion, telomeric The cell cycle process in which telomeres of sister chromatids are joined during mitosis. go.json mitotic sister chromatid cohesion at telomere|sister chromatid cohesion at telomere at mitosis|telomeric mitotic sister chromatin cohesion http://purl.obolibrary.org/obo/GO_0099404 GO:1905690 biolink:BiologicalProcess nucleus disassembly The disaggregation of a nucleus into its constituent components. go.json cell nucleus disassembly http://purl.obolibrary.org/obo/GO_1905690 GO:1905691 biolink:BiologicalProcess lipid droplet disassembly The disaggregation of a lipid particle into its constituent components. go.json adiposome disassembly|lipid body disassembly|lipid droplet reserve breakdown|lipid particle disassembly http://purl.obolibrary.org/obo/GO_1905691 GO:1905692 biolink:BiologicalProcess endoplasmic reticulum disassembly The disaggregation of an endoplasmic reticulum into its constituent components. go.json ER disassembly http://purl.obolibrary.org/obo/GO_1905692 GO:1905693 biolink:BiologicalProcess regulation of phosphatidic acid biosynthetic process Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process. go.json regulation of phosphatidic acid anabolism|regulation of phosphatidic acid biosynthesis|regulation of phosphatidic acid formation|regulation of phosphatidic acid synthesis http://purl.obolibrary.org/obo/GO_1905693 GO:1905694 biolink:BiologicalProcess negative regulation of phosphatidic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidic acid biosynthetic process. go.json down regulation of phosphatidic acid anabolism|down regulation of phosphatidic acid biosynthesis|down regulation of phosphatidic acid biosynthetic process|down regulation of phosphatidic acid formation|down regulation of phosphatidic acid synthesis|down-regulation of phosphatidic acid anabolism|down-regulation of phosphatidic acid biosynthesis|down-regulation of phosphatidic acid biosynthetic process|down-regulation of phosphatidic acid formation|down-regulation of phosphatidic acid synthesis|downregulation of phosphatidic acid anabolism|downregulation of phosphatidic acid biosynthesis|downregulation of phosphatidic acid biosynthetic process|downregulation of phosphatidic acid formation|downregulation of phosphatidic acid synthesis|inhibition of phosphatidic acid anabolism|inhibition of phosphatidic acid biosynthesis|inhibition of phosphatidic acid biosynthetic process|inhibition of phosphatidic acid formation|inhibition of phosphatidic acid synthesis|negative regulation of phosphatidic acid anabolism|negative regulation of phosphatidic acid biosynthesis|negative regulation of phosphatidic acid formation|negative regulation of phosphatidic acid synthesis http://purl.obolibrary.org/obo/GO_1905694 GO:1905695 biolink:BiologicalProcess positive regulation of phosphatidic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process. go.json activation of phosphatidic acid anabolism|activation of phosphatidic acid biosynthesis|activation of phosphatidic acid biosynthetic process|activation of phosphatidic acid formation|activation of phosphatidic acid synthesis|positive regulation of phosphatidic acid anabolism|positive regulation of phosphatidic acid biosynthesis|positive regulation of phosphatidic acid formation|positive regulation of phosphatidic acid synthesis|up regulation of phosphatidic acid anabolism|up regulation of phosphatidic acid biosynthesis|up regulation of phosphatidic acid biosynthetic process|up regulation of phosphatidic acid formation|up regulation of phosphatidic acid synthesis|up-regulation of phosphatidic acid anabolism|up-regulation of phosphatidic acid biosynthesis|up-regulation of phosphatidic acid biosynthetic process|up-regulation of phosphatidic acid formation|up-regulation of phosphatidic acid synthesis|upregulation of phosphatidic acid anabolism|upregulation of phosphatidic acid biosynthesis|upregulation of phosphatidic acid biosynthetic process|upregulation of phosphatidic acid formation|upregulation of phosphatidic acid synthesis http://purl.obolibrary.org/obo/GO_1905695 GO:1905696 biolink:BiologicalProcess regulation of polysome binding Any process that modulates the frequency, rate or extent of polysome binding. go.json regulation of polyribosome binding http://purl.obolibrary.org/obo/GO_1905696 gocheck_do_not_annotate GO:1905686 biolink:BiologicalProcess positive regulation of plasma membrane repair Any process that activates or increases the frequency, rate or extent of plasma membrane repair. go.json activation of plasma membrane repair|up regulation of plasma membrane repair|up-regulation of plasma membrane repair|upregulation of plasma membrane repair http://purl.obolibrary.org/obo/GO_1905686 GO:1905687 biolink:BiologicalProcess regulation of diacylglycerol kinase activity Any process that modulates the frequency, rate or extent of diacylglycerol kinase activity. go.json regulation of 1,2-diacylglycerol kinase (phosphorylating)|regulation of 1,2-diacylglycerol kinase activity|regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|regulation of ATP:diacylglycerol phosphotransferase activity|regulation of CTP:diacylglycerol kinase activity|regulation of DG kinase activity|regulation of DGK activity|regulation of arachidonoyl-specific diacylglycerol kinase activity|regulation of diacylglycerol:ATP kinase activity|regulation of diglyceride kinase activity|regulation of sn-1,2-diacylglycerol kinase activity http://purl.obolibrary.org/obo/GO_1905687 gocheck_do_not_annotate GO:1905688 biolink:BiologicalProcess negative regulation of diacylglycerol kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity. go.json down regulation of 1,2-diacylglycerol kinase (phosphorylating)|down regulation of 1,2-diacylglycerol kinase activity|down regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|down regulation of ATP:diacylglycerol phosphotransferase activity|down regulation of CTP:diacylglycerol kinase activity|down regulation of DG kinase activity|down regulation of DGK activity|down regulation of arachidonoyl-specific diacylglycerol kinase activity|down regulation of diacylglycerol kinase activity|down regulation of diacylglycerol:ATP kinase activity|down regulation of diglyceride kinase activity|down regulation of sn-1,2-diacylglycerol kinase activity|down-regulation of 1,2-diacylglycerol kinase (phosphorylating)|down-regulation of 1,2-diacylglycerol kinase activity|down-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|down-regulation of ATP:diacylglycerol phosphotransferase activity|down-regulation of CTP:diacylglycerol kinase activity|down-regulation of DG kinase activity|down-regulation of DGK activity|down-regulation of arachidonoyl-specific diacylglycerol kinase activity|down-regulation of diacylglycerol kinase activity|down-regulation of diacylglycerol:ATP kinase activity|down-regulation of diglyceride kinase activity|down-regulation of sn-1,2-diacylglycerol kinase activity|downregulation of 1,2-diacylglycerol kinase (phosphorylating)|downregulation of 1,2-diacylglycerol kinase activity|downregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|downregulation of ATP:diacylglycerol phosphotransferase activity|downregulation of CTP:diacylglycerol kinase activity|downregulation of DG kinase activity|downregulation of DGK activity|downregulation of arachidonoyl-specific diacylglycerol kinase activity|downregulation of diacylglycerol kinase activity|downregulation of diacylglycerol:ATP kinase activity|downregulation of diglyceride kinase activity|downregulation of sn-1,2-diacylglycerol kinase activity|inhibition of 1,2-diacylglycerol kinase (phosphorylating)|inhibition of 1,2-diacylglycerol kinase activity|inhibition of ATP:1,2-diacylglycerol 3-phosphotransferase activity|inhibition of ATP:diacylglycerol phosphotransferase activity|inhibition of CTP:diacylglycerol kinase activity|inhibition of DG kinase activity|inhibition of DGK activity|inhibition of arachidonoyl-specific diacylglycerol kinase activity|inhibition of diacylglycerol kinase activity|inhibition of diacylglycerol:ATP kinase activity|inhibition of diglyceride kinase activity|inhibition of sn-1,2-diacylglycerol kinase activity|negative regulation of 1,2-diacylglycerol kinase (phosphorylating)|negative regulation of 1,2-diacylglycerol kinase activity|negative regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|negative regulation of ATP:diacylglycerol phosphotransferase activity|negative regulation of CTP:diacylglycerol kinase activity|negative regulation of DG kinase activity|negative regulation of DGK activity|negative regulation of arachidonoyl-specific diacylglycerol kinase activity|negative regulation of diacylglycerol:ATP kinase activity|negative regulation of diglyceride kinase activity|negative regulation of sn-1,2-diacylglycerol kinase activity http://purl.obolibrary.org/obo/GO_1905688 gocheck_do_not_annotate GO:1905689 biolink:BiologicalProcess positive regulation of diacylglycerol kinase activity Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity. go.json activation of 1,2-diacylglycerol kinase (phosphorylating)|activation of 1,2-diacylglycerol kinase activity|activation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|activation of ATP:diacylglycerol phosphotransferase activity|activation of CTP:diacylglycerol kinase activity|activation of DG kinase activity|activation of DGK activity|activation of arachidonoyl-specific diacylglycerol kinase activity|activation of diacylglycerol kinase activity|activation of diacylglycerol:ATP kinase activity|activation of diglyceride kinase activity|activation of sn-1,2-diacylglycerol kinase activity|positive regulation of 1,2-diacylglycerol kinase (phosphorylating)|positive regulation of 1,2-diacylglycerol kinase activity|positive regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|positive regulation of ATP:diacylglycerol phosphotransferase activity|positive regulation of CTP:diacylglycerol kinase activity|positive regulation of DG kinase activity|positive regulation of DGK activity|positive regulation of arachidonoyl-specific diacylglycerol kinase activity|positive regulation of diacylglycerol:ATP kinase activity|positive regulation of diglyceride kinase activity|positive regulation of sn-1,2-diacylglycerol kinase activity|up regulation of 1,2-diacylglycerol kinase (phosphorylating)|up regulation of 1,2-diacylglycerol kinase activity|up regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|up regulation of ATP:diacylglycerol phosphotransferase activity|up regulation of CTP:diacylglycerol kinase activity|up regulation of DG kinase activity|up regulation of DGK activity|up regulation of arachidonoyl-specific diacylglycerol kinase activity|up regulation of diacylglycerol kinase activity|up regulation of diacylglycerol:ATP kinase activity|up regulation of diglyceride kinase activity|up regulation of sn-1,2-diacylglycerol kinase activity|up-regulation of 1,2-diacylglycerol kinase (phosphorylating)|up-regulation of 1,2-diacylglycerol kinase activity|up-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|up-regulation of ATP:diacylglycerol phosphotransferase activity|up-regulation of CTP:diacylglycerol kinase activity|up-regulation of DG kinase activity|up-regulation of DGK activity|up-regulation of arachidonoyl-specific diacylglycerol kinase activity|up-regulation of diacylglycerol kinase activity|up-regulation of diacylglycerol:ATP kinase activity|up-regulation of diglyceride kinase activity|up-regulation of sn-1,2-diacylglycerol kinase activity|upregulation of 1,2-diacylglycerol kinase (phosphorylating)|upregulation of 1,2-diacylglycerol kinase activity|upregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity|upregulation of ATP:diacylglycerol phosphotransferase activity|upregulation of CTP:diacylglycerol kinase activity|upregulation of DG kinase activity|upregulation of DGK activity|upregulation of arachidonoyl-specific diacylglycerol kinase activity|upregulation of diacylglycerol kinase activity|upregulation of diacylglycerol:ATP kinase activity|upregulation of diglyceride kinase activity|upregulation of sn-1,2-diacylglycerol kinase activity http://purl.obolibrary.org/obo/GO_1905689 gocheck_do_not_annotate GO:1905697 biolink:BiologicalProcess negative regulation of polysome binding Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding. go.json down regulation of polyribosome binding|down regulation of polysome binding|down-regulation of polyribosome binding|down-regulation of polysome binding|downregulation of polyribosome binding|downregulation of polysome binding|inhibition of polyribosome binding|inhibition of polysome binding|negative regulation of polyribosome binding http://purl.obolibrary.org/obo/GO_1905697 gocheck_do_not_annotate GO:1905698 biolink:BiologicalProcess positive regulation of polysome binding Any process that activates or increases the frequency, rate or extent of polysome binding. go.json activation of polyribosome binding|activation of polysome binding|positive regulation of polyribosome binding|up regulation of polyribosome binding|up regulation of polysome binding|up-regulation of polyribosome binding|up-regulation of polysome binding|upregulation of polyribosome binding|upregulation of polysome binding http://purl.obolibrary.org/obo/GO_1905698 gocheck_do_not_annotate GO:1905699 biolink:BiologicalProcess regulation of xenobiotic detoxification by transmembrane export across the plasma membrane Any process that modulates the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json regulation of drug transmembrane export|regulation of xenobiotic transmembrane export http://purl.obolibrary.org/obo/GO_1905699 GO:2000607 biolink:BiologicalProcess negative regulation of cell proliferation involved in mesonephros development Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development. go.json http://purl.obolibrary.org/obo/GO_2000607 GO:2000608 biolink:BiologicalProcess positive regulation of cell proliferation involved in mesonephros development Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development. go.json http://purl.obolibrary.org/obo/GO_2000608 GO:2000609 biolink:BiologicalProcess regulation of thyroid hormone generation Any process that modulates the frequency, rate or extent of thyroid hormone generation. go.json http://purl.obolibrary.org/obo/GO_2000609 GO:2000600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000600 GO:2000601 biolink:BiologicalProcess positive regulation of Arp2/3 complex-mediated actin nucleation Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation. go.json positive regulation of actin filament branch nucleation|positive regulation of branched actin filament nucleation http://purl.obolibrary.org/obo/GO_2000601 GO:2000602 biolink:BiologicalProcess obsolete regulation of interphase of mitotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle. go.json regulation of interphase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2000602 GO:2000603 biolink:BiologicalProcess regulation of secondary growth Any process that modulates the frequency, rate or extent of secondary growth. go.json http://purl.obolibrary.org/obo/GO_2000603 GO:2000604 biolink:BiologicalProcess negative regulation of secondary growth Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth. go.json http://purl.obolibrary.org/obo/GO_2000604 GO:2000605 biolink:BiologicalProcess positive regulation of secondary growth Any process that activates or increases the frequency, rate or extent of secondary growth. go.json http://purl.obolibrary.org/obo/GO_2000605 GO:2000606 biolink:BiologicalProcess regulation of cell proliferation involved in mesonephros development Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development. go.json http://purl.obolibrary.org/obo/GO_2000606 GO:2000618 biolink:BiologicalProcess obsolete regulation of histone H4-K16 acetylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation. go.json regulation of histone H4 acetylation at K16 True http://purl.obolibrary.org/obo/GO_2000618 GO:2000619 biolink:BiologicalProcess obsolete negative regulation of histone H4-K16 acetylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation. go.json negative regulation of histone H4 acetylation at K16 True http://purl.obolibrary.org/obo/GO_2000619 GO:2000610 biolink:BiologicalProcess negative regulation of thyroid hormone generation Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation. go.json http://purl.obolibrary.org/obo/GO_2000610 GO:2000611 biolink:BiologicalProcess positive regulation of thyroid hormone generation Any process that activates or increases the frequency, rate or extent of thyroid hormone generation. go.json http://purl.obolibrary.org/obo/GO_2000611 GO:2000612 biolink:BiologicalProcess regulation of thyroid-stimulating hormone secretion Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion. go.json regulation of TSH secretion|regulation of thyroid stimulating hormone secretion http://purl.obolibrary.org/obo/GO_2000612 GO:2000613 biolink:BiologicalProcess negative regulation of thyroid-stimulating hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion. go.json negative regulation of TSH secretion|negative regulation of thyroid stimulating hormone secretion http://purl.obolibrary.org/obo/GO_2000613 GO:2000614 biolink:BiologicalProcess positive regulation of thyroid-stimulating hormone secretion Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion. go.json positive regulation of TSH secretion|positive regulation of thyroid stimulating hormone secretion http://purl.obolibrary.org/obo/GO_2000614 GO:2000615 biolink:BiologicalProcess regulation of histone H3-K9 acetylation Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. go.json regulation of histone H3 acetylation at K9|regulation of histone H3K9 acetylation http://purl.obolibrary.org/obo/GO_2000615 GO:2000616 biolink:BiologicalProcess negative regulation of histone H3-K9 acetylation Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation. go.json negative regulation of histone H3 acetylation at K9|negative regulation of histone H3K9 acetylation http://purl.obolibrary.org/obo/GO_2000616 GO:2000617 biolink:BiologicalProcess positive regulation of histone H3-K9 acetylation Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation. go.json positive regulation of histone H3 acetylation at K9|positive regulation of histone H3K9 acetylation http://purl.obolibrary.org/obo/GO_2000617 GO:0002467 biolink:BiologicalProcess germinal center formation The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. go.json http://purl.obolibrary.org/obo/GO_0002467 GO:0002468 biolink:BiologicalProcess dendritic cell antigen processing and presentation The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002468 GO:0002469 biolink:BiologicalProcess myeloid dendritic cell antigen processing and presentation The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002469 GO:0002463 biolink:BiologicalProcess central tolerance induction to nonself antigen Tolerance induction to nonself antigens in the central lymphoid organs. go.json http://purl.obolibrary.org/obo/GO_0002463 GO:0002464 biolink:BiologicalProcess peripheral tolerance induction to nonself antigen Tolerance induction to nonself antigens in the periphery. go.json http://purl.obolibrary.org/obo/GO_0002464 GO:0002465 biolink:BiologicalProcess peripheral tolerance induction Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. go.json http://purl.obolibrary.org/obo/GO_0002465 GO:0002466 biolink:BiologicalProcess peripheral tolerance induction to self antigen Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. go.json http://purl.obolibrary.org/obo/GO_0002466 GO:0002460 biolink:BiologicalProcess adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0002460 GO:0002461 biolink:BiologicalProcess tolerance induction dependent upon immune response Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation. go.json immune response-dependent tolerance induction http://purl.obolibrary.org/obo/GO_0002461 GO:0002462 biolink:BiologicalProcess tolerance induction to nonself antigen Tolerance induction in response to nonself antigens. go.json http://purl.obolibrary.org/obo/GO_0002462 GO:0051401 biolink:MolecularActivity CH domain binding Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins. go.json calponin homology domain binding http://purl.obolibrary.org/obo/GO_0051401 GO:0002478 biolink:BiologicalProcess antigen processing and presentation of exogenous peptide antigen The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. go.json exogenous peptide antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002478 GO:0002479 biolink:BiologicalProcess antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules. go.json TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I|TAP-dependent exogenous peptide antigen processing and presentation via MHC class I|cross presentation|cross-presentation|exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent http://purl.obolibrary.org/obo/GO_0002479 GO:0051402 biolink:BiologicalProcess neuron apoptotic process Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. go.json apoptosis of neuronal cells|apoptosis of neurons|neuron apoptosis|neuron programmed cell death by apoptosis|neuronal cell apoptosis|neuronal cell programmed cell death by apoptosis|programmed cell death of neuronal cells by apoptosis|programmed cell death of neurons by apoptosis|programmed cell death, neuronal cells|programmed cell death, neurons http://purl.obolibrary.org/obo/GO_0051402 GO:0051400 biolink:MolecularActivity BH domain binding Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. go.json Bcl-2 homology domain binding http://purl.obolibrary.org/obo/GO_0051400 goslim_chembl GO:0051405 biolink:MolecularActivity obsolete microbial collagenase activity OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds. go.json Achromobacter iophagus collagenase|Clostridium histolyticum collagenase activity|Clostridium histolyticum proteinase A|aspergillopeptidase C|azocollase activity|clostridiopeptidase A activity|clostridiopeptidase I|clostridiopeptidase II|collagen peptidase activity|collagen protease activity|collagenase 1 activity|collagenase A activity|collagenase I activity|collagenase MMP-1|kollaza|matirx metalloproteinase-18|matrix metalloproteinase-1|matrix metalloproteinase-8|metallocollagenase activity|metalloproteinase-1|microbial collagenase activity|nucleolysin|soycollagestin True http://purl.obolibrary.org/obo/GO_0051405 GO:0002474 biolink:BiologicalProcess antigen processing and presentation of peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. go.json peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_0002474 GO:0002475 biolink:BiologicalProcess antigen processing and presentation via MHC class Ib The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. go.json http://purl.obolibrary.org/obo/GO_0002475 GO:0051406 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051406 GO:0002476 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json endogenous peptide antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002476 GO:0051403 biolink:BiologicalProcess stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. go.json MAPK11 cascade|MAPK12 cascade|MAPK13 cascade|MAPK14 cascade|SAPK cascade|p38 MAPK signaling|p38 MAPK signalling|p38 cascade|stress-activated MAPK signaling pathway|stress-activated MAPK signalling pathway|stress-activated MAPKKK cascade|stress-activated MAPKKK signaling pathway|stress-activated MAPKKK signalling pathway http://purl.obolibrary.org/obo/GO_0051403 GO:0051404 biolink:MolecularActivity obsolete clostripain activity OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds. go.json Clostridium histolyticum proteinase B|alpha-clostridipain|clostridiopeptidase B activity|clostripain activity True http://purl.obolibrary.org/obo/GO_0051404 GO:0002477 biolink:BiologicalProcess antigen processing and presentation of exogenous peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json exogenous peptide antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002477 GO:0051409 biolink:BiologicalProcess response to nitrosative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. go.json http://purl.obolibrary.org/obo/GO_0051409 GO:0002470 biolink:BiologicalProcess plasmacytoid dendritic cell antigen processing and presentation The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002470 GO:0002471 biolink:BiologicalProcess monocyte antigen processing and presentation The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002471 GO:0002472 biolink:BiologicalProcess macrophage antigen processing and presentation The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json http://purl.obolibrary.org/obo/GO_0002472 GO:0051407 biolink:MolecularActivity glycerone phosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out). go.json dihydroxyacetone-phosphate:inorganic phosphate antiporter activity http://purl.obolibrary.org/obo/GO_0051407 GO:0051408 biolink:MolecularActivity glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out). go.json http://purl.obolibrary.org/obo/GO_0051408 GO:0002473 biolink:BiologicalProcess non-professional antigen presenting cell antigen processing and presentation The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils. go.json http://purl.obolibrary.org/obo/GO_0002473 GO:0051412 biolink:BiologicalProcess response to corticosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. go.json response to corticosterone stimulus http://purl.obolibrary.org/obo/GO_0051412 GO:0002445 biolink:BiologicalProcess type II hypersensitivity An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. Wikipedia:Type_II_hypersensitivity go.json http://purl.obolibrary.org/obo/GO_0002445 GO:0002446 biolink:BiologicalProcess neutrophil mediated immunity Any process involved in the carrying out of an immune response by a neutrophil. go.json http://purl.obolibrary.org/obo/GO_0002446 GO:0051413 biolink:BiologicalProcess response to cortisone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues. go.json response to cortisone stimulus http://purl.obolibrary.org/obo/GO_0051413 GO:0051410 biolink:BiologicalProcess detoxification of nitrogen compound Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. go.json detoxification of nitrogenous compound|nitric oxide (NO) detoxification http://purl.obolibrary.org/obo/GO_0051410 GO:0002447 biolink:BiologicalProcess eosinophil mediated immunity Any process involved in the carrying out of an immune response by an eosinophil. go.json http://purl.obolibrary.org/obo/GO_0002447 GO:0002448 biolink:BiologicalProcess mast cell mediated immunity Any process involved in the carrying out of an immune response by a mast cell. go.json http://purl.obolibrary.org/obo/GO_0002448 GO:0051411 biolink:MolecularActivity obsolete ALP binding OBSOLETE. Interacting selectively and non-covalently wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band. go.json ALP binding|actinin-associated LIM protein binding True http://purl.obolibrary.org/obo/GO_0051411 GO:0051416 biolink:MolecularActivity obsolete myotilin binding OBSOLETE. Binding to myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C. go.json myotilin binding True http://purl.obolibrary.org/obo/GO_0051416 GO:0002441 biolink:BiologicalProcess histamine secretion involved in inflammatory response The regulated release of histamine by a cell as part of an inflammatory response. go.json histamine secretion involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002441 GO:0002442 biolink:BiologicalProcess serotonin secretion involved in inflammatory response The regulated release of serotonin by a cell as part of an inflammatory response. go.json serotonin release involved in inflammatory response|serotonin secretion involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0002442 GO:0051417 biolink:BiologicalProcess microtubule nucleation by spindle pole body The 'de novo' formation of a microtubule, mediated by the spindle pole body. go.json SPB-mediated microtubule nucleation|microtubule nucleation by SPB|spindle pole body-mediated microtubule nucleation http://purl.obolibrary.org/obo/GO_0051417 GO:0002443 biolink:BiologicalProcess leukocyte mediated immunity Any process involved in the carrying out of an immune response by a leukocyte. go.json cell-mediated immune response|cellular immune response|immune cell effector process|immune cell mediated immunity|leucocyte immune effector process|leucocyte mediated immunity|leukocyte immune effector process http://purl.obolibrary.org/obo/GO_0002443 GO:0051414 biolink:BiologicalProcess response to cortisol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. go.json response to cortisol stimulus|response to hydrocortisone stimulus http://purl.obolibrary.org/obo/GO_0051414 GO:0051415 biolink:BiologicalProcess microtubule nucleation by interphase microtubule organizing center The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation. go.json IMTOC-mediated microtubule nucleation during interphase|interphase microtubule nucleation by interphase microtubule organising centre|interphase microtubule nucleation by interphase microtubule organizing center|interphase microtubule organizing center-mediated microtubule nucleation during interphase|microtubule nucleation during interphase by IMTOC|microtubule nucleation during interphase by interphase microtubule organizing center http://purl.obolibrary.org/obo/GO_0051415 GO:0002444 biolink:BiologicalProcess myeloid leukocyte mediated immunity Any process involved in the carrying out of an immune response by a myeloid leukocyte. go.json myeloid leucocyte immune effector process|myeloid leucocyte mediated immunity|myeloid leukocyte immune effector process http://purl.obolibrary.org/obo/GO_0002444 GO:0051418 biolink:BiologicalProcess microtubule nucleation by microtubule organizing center The 'de novo' formation of a microtubule, mediated by the microtubule organizing center. go.json MTOC-mediated microtubule nucleation|microtubule nucleation by MTOC|microtubule nucleation by microtubule organising centre|microtubule organizing center-mediated microtubule nucleation http://purl.obolibrary.org/obo/GO_0051418 GO:0002440 biolink:BiologicalProcess production of molecular mediator of immune response The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. go.json production of cellular mediator of immune response http://purl.obolibrary.org/obo/GO_0002440 gocheck_do_not_annotate GO:0051419 biolink:MolecularActivity obsolete nebulin binding OBSOLETE. Binding to nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone. go.json nebulin binding True http://purl.obolibrary.org/obo/GO_0051419 GO:0002449 biolink:BiologicalProcess lymphocyte mediated immunity Any process involved in the carrying out of an immune response by a lymphocyte. go.json cell-mediated immunity|cellular immune response http://purl.obolibrary.org/obo/GO_0002449 GO:0002456 biolink:BiologicalProcess T cell mediated immunity Any process involved in the carrying out of an immune response by a T cell. go.json T lymphocyte mediated immunity|T-cell mediated immunity|T-lymphocyte mediated immunity|cell-mediated immunity|cellular immune response http://purl.obolibrary.org/obo/GO_0002456 GO:0051423 biolink:BiologicalProcess obsolete positive regulation of endo-1,4-beta-xylanase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. go.json activation of endo-1,4-beta-xylanase activity|endo-1,4-beta-xylanase activator|stimulation of endo-1,4-beta-xylanase activity|up regulation of endo-1,4-beta-xylanase activity|up-regulation of endo-1,4-beta-xylanase activity|upregulation of endo-1,4-beta-xylanase activity|xylanase activator True http://purl.obolibrary.org/obo/GO_0051423 GO:0051424 biolink:MolecularActivity corticotropin-releasing hormone binding Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. go.json CRF binding|CRH binding|corticoliberin binding|corticotropin-releasing factor binding http://purl.obolibrary.org/obo/GO_0051424 GO:0002457 biolink:BiologicalProcess T cell antigen processing and presentation The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json T lymphocyte antigen processing and presentation|T-cell antigen processing and presentation|T-lymphocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002457 GO:0002458 biolink:BiologicalProcess peripheral T cell tolerance induction Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus. go.json peripheral T lymphocyte tolerance induction|peripheral T-cell tolerance induction|peripheral T-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002458 GO:0051421 biolink:BiologicalProcess obsolete regulation of endo-1,4-beta-xylanase activity OBSOLETE. Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. go.json endo-1,4-beta-xylanase regulator|xylanase regulator True http://purl.obolibrary.org/obo/GO_0051421 GO:0002459 biolink:BiologicalProcess adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae). go.json adaptive immune response based on somatic recombination of VLR built from LRR domains|adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains|adaptive immune response in jawless fish http://purl.obolibrary.org/obo/GO_0002459 GO:0051422 biolink:BiologicalProcess obsolete negative regulation of endo-1,4-beta-xylanase activity OBSOLETE. Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. go.json down regulation of endo-1,4-beta-xylanase activity|down-regulation of endo-1,4-beta-xylanase activity|downregulation of endo-1,4-beta-xylanase activity|endo-1,4-beta-xylanase inhibitor|inhibition of endo-1,4-beta-xylanase activity|xylanase inhibitor True http://purl.obolibrary.org/obo/GO_0051422 GO:0002452 biolink:BiologicalProcess B cell receptor editing The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor. go.json B lymphocyte receptor editing|B-cell receptor editing|B-lymphocyte receptor editing http://purl.obolibrary.org/obo/GO_0002452 GO:0051427 biolink:MolecularActivity hormone receptor binding Binding to a receptor for a hormone. go.json http://purl.obolibrary.org/obo/GO_0051427 GO:0002453 biolink:BiologicalProcess peripheral B cell anergy Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells. go.json peripheral B lymphocyte anergy|peripheral B-cell anergy|peripheral B-lymphocyte anergy http://purl.obolibrary.org/obo/GO_0002453 GO:0051428 biolink:MolecularActivity peptide hormone receptor binding Binding to a receptor for a peptide hormone. go.json polypeptide hormone receptor binding http://purl.obolibrary.org/obo/GO_0051428 goslim_chembl GO:0002454 biolink:BiologicalProcess peripheral B cell deletion The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection. go.json peripheral B lymphocyte deletion|peripheral B-cell deletion|peripheral B-lymphocyte deletion http://purl.obolibrary.org/obo/GO_0002454 GO:0051425 biolink:MolecularActivity PTB domain binding Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain. go.json PID binding|phosphotyrosine-interacting domain binding http://purl.obolibrary.org/obo/GO_0051425 GO:0002455 biolink:BiologicalProcess humoral immune response mediated by circulating immunoglobulin An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. go.json circulating antibody mediated immune response|circulating immunoglobulin mediated immune response|humoral defence mechanism|humoral immune response mediated by circulating antibody http://purl.obolibrary.org/obo/GO_0002455 GO:0051426 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0051426 GO:0002450 biolink:BiologicalProcess B cell antigen processing and presentation The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. go.json B lymphocyte antigen processing and presentation|B-cell antigen processing and presentation|B-lymphocyte antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002450 GO:0051429 biolink:MolecularActivity corticotropin-releasing hormone receptor binding Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. go.json CRF receptor binding|CRH receptor binding|CRHR binding|corticotropin releasing factor receptor binding|corticotropin releasing factor receptor ligand|corticotropin-releasing factor receptor binding http://purl.obolibrary.org/obo/GO_0051429 GO:0002451 biolink:BiologicalProcess peripheral B cell tolerance induction Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue. go.json peripheral B lymphocyte tolerance induction|peripheral B-cell tolerance induction|peripheral B-lymphocyte tolerance induction http://purl.obolibrary.org/obo/GO_0002451 GO:0051420 biolink:MolecularActivity obsolete nebulette binding OBSOLETE. Binding to nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin. go.json nebulette binding True http://purl.obolibrary.org/obo/GO_0051420 GO:0002423 biolink:BiologicalProcess natural killer cell mediated immune response to tumor cell An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell. go.json http://purl.obolibrary.org/obo/GO_0002423 GO:0051434 biolink:MolecularActivity BH3 domain binding Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. go.json http://purl.obolibrary.org/obo/GO_0051434 goslim_chembl GO:0051435 biolink:MolecularActivity BH4 domain binding Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein. go.json http://purl.obolibrary.org/obo/GO_0051435 GO:0002424 biolink:BiologicalProcess T cell mediated immune response to tumor cell An immune response mediated by a T cell triggered in response to the presence of a tumor cell. go.json http://purl.obolibrary.org/obo/GO_0002424 GO:0002425 biolink:BiologicalProcess tolerance induction in urogenital tract Tolerance induction taking place in the urogenital tract. go.json http://purl.obolibrary.org/obo/GO_0002425 GO:0051432 biolink:MolecularActivity BH1 domain binding Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. go.json http://purl.obolibrary.org/obo/GO_0051432 GO:0051433 biolink:MolecularActivity BH2 domain binding Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. go.json http://purl.obolibrary.org/obo/GO_0051433 GO:0002426 biolink:BiologicalProcess immunoglobulin production in mucosal tissue The synthesis and release of immunoglobulin in the mucosal tissue. go.json antibody production in mucosal tissue http://purl.obolibrary.org/obo/GO_0002426 gocheck_do_not_annotate GO:0051438 biolink:BiologicalProcess regulation of ubiquitin-protein transferase activity Any process that modulates the frequency, rate or extent of ubiquitin transferase activity. go.json APC regulator|SCF complex regulator|anaphase-promoting complex regulator|regulation of ubiquitin transferase activity|ubiquitin transferase regulator|ubiquitin-protein transferase regulator http://purl.obolibrary.org/obo/GO_0051438 gocheck_do_not_annotate GO:0051439 biolink:BiologicalProcess obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. go.json mitotic APC regulator|mitotic SCF complex regulator|mitotic anaphase-promoting complex regulator|mitotic ubiquitin ligase regulator|mitotic ubiquitin-protein ligase regulator|regulation of ubiquitin ligase activity during mitotic cell cycle|regulation of ubiquitin-protein ligase activity during mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0051439 GO:0002420 biolink:BiologicalProcess natural killer cell mediated cytotoxicity directed against tumor cell target The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. go.json NK cell mediated cytotoxicity directed against tumor cell target http://purl.obolibrary.org/obo/GO_0002420 GO:0051436 biolink:BiologicalProcess obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. go.json APC inhibition during mitotic cell cycle|anaphase promoting complex inhibition during mitotic cell cycle|anaphase-promoting complex inhibition during mitotic cell cycle|down regulation of ubiquitin ligase activity during mitotic cell cycle|down-regulation of ubiquitin ligase activity during mitotic cell cycle|downregulation of ubiquitin ligase activity during mitotic cell cycle|inhibition of ubiquitin ligase activity during mitotic cell cycle|mitotic APC inhibition|mitotic APC inhibitor|mitotic SCF complex inhibitor|mitotic anaphase promoting complex inhibition|mitotic anaphase promoting complex inhibitor|mitotic anaphase-promoting complex inhibition|mitotic anaphase-promoting complex inhibitor|mitotic ubiquitin ligase inhibitor|negative regulation of ubiquitin ligase activity during mitotic cell cycle|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0051436 GO:0002421 biolink:BiologicalProcess B cell antigen processing and presentation following pinocytosis B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. go.json B lymphocyte antigen processing and presentation following pinocytosis|B-cell antigen processing and presentation following pinocytosis|B-lymphocyte antigen processing and presentation following pinocytosis http://purl.obolibrary.org/obo/GO_0002421 GO:0051437 biolink:BiologicalProcess obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition. go.json activation of ubiquitin ligase activity during mitotic cell cycle|mitotic SCF complex activator|mitotic ubiquitin ligase activator|positive regulation of ubiquitin ligase activity during mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle|stimulation of ubiquitin ligase activity during mitotic cell cycle|up regulation of ubiquitin ligase activity during mitotic cell cycle|up-regulation of ubiquitin ligase activity during mitotic cell cycle|upregulation of ubiquitin ligase activity during mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0051437 GO:0002422 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0002422 GO:2000665 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000665 GO:2000666 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000666 GO:2000667 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000667 GO:2000668 biolink:BiologicalProcess regulation of dendritic cell apoptotic process Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process. go.json regulation of dendritic cell apoptosis http://purl.obolibrary.org/obo/GO_2000668 GO:2000669 biolink:BiologicalProcess negative regulation of dendritic cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. go.json negative regulation of dendritic cell apoptosis http://purl.obolibrary.org/obo/GO_2000669 GO:1905600 biolink:BiologicalProcess regulation of receptor-mediated endocytosis involved in cholesterol transport Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. go.json regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|regulation of receptor-mediated endocytosis of LDL|regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport http://purl.obolibrary.org/obo/GO_1905600 GO:1905601 biolink:BiologicalProcess negative regulation of receptor-mediated endocytosis involved in cholesterol transport Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. go.json down regulation of receptor-mediated endocytosis involved in cholesterol transport|down regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|down regulation of receptor-mediated endocytosis of LDL|down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|down-regulation of receptor-mediated endocytosis involved in cholesterol transport|down-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|down-regulation of receptor-mediated endocytosis of LDL|down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|downregulation of receptor-mediated endocytosis involved in cholesterol transport|downregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|downregulation of receptor-mediated endocytosis of LDL|downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|inhibition of receptor-mediated endocytosis involved in cholesterol transport|inhibition of receptor-mediated endocytosis involved in intracellular cholesterol transport|inhibition of receptor-mediated endocytosis of LDL|inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|negative regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|negative regulation of receptor-mediated endocytosis of LDL|negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport http://purl.obolibrary.org/obo/GO_1905601 GO:2000660 biolink:BiologicalProcess negative regulation of interleukin-1-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway. go.json negative regulation of IL-1 alpha-mediated signaling pathway|negative regulation of IL-1 beta-mediated signaling pathway|negative regulation of IL-1-mediated signaling pathway|negative regulation of interleukin-1 alpha-mediated signaling pathway|negative regulation of interleukin-1 beta-mediated signaling pathway|negative regulation of interleukin-1-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000660 GO:1905602 biolink:BiologicalProcess positive regulation of receptor-mediated endocytosis involved in cholesterol transport Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. go.json activation of receptor-mediated endocytosis involved in cholesterol transport|activation of receptor-mediated endocytosis involved in intracellular cholesterol transport|activation of receptor-mediated endocytosis of LDL|activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|positive regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|positive regulation of receptor-mediated endocytosis of LDL|positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|up regulation of receptor-mediated endocytosis involved in cholesterol transport|up regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|up regulation of receptor-mediated endocytosis of LDL|up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|up-regulation of receptor-mediated endocytosis involved in cholesterol transport|up-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|up-regulation of receptor-mediated endocytosis of LDL|up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|upregulation of receptor-mediated endocytosis involved in cholesterol transport|upregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|upregulation of receptor-mediated endocytosis of LDL|upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport http://purl.obolibrary.org/obo/GO_1905602 GO:2000661 biolink:BiologicalProcess positive regulation of interleukin-1-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway. go.json positive regulation of IL-1 alpha-mediated signaling pathway|positive regulation of IL-1 beta-mediated signaling pathway|positive regulation of IL-1-mediated signaling pathway|positive regulation of interleukin-1 alpha-mediated signaling pathway|positive regulation of interleukin-1 beta-mediated signaling pathway|positive regulation of interleukin-1-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2000661 GO:1905603 biolink:BiologicalProcess regulation of blood-brain barrier permeability Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. go.json regulation of BBB permeability|regulation of blood/brain barrier permeability http://purl.obolibrary.org/obo/GO_1905603 GO:2000662 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000662 GO:1905604 biolink:BiologicalProcess negative regulation of blood-brain barrier permeability Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. go.json down-regulation of BBB permeability|down-regulation of blood-brain barrier permeability|down-regulation of blood/brain barrier permeability|downregulation of BBB permeability|downregulation of blood-brain barrier permeability|downregulation of blood/brain barrier permeability|inhibition of maintenance of permeability of BBB|inhibition of maintenance of permeability of blood-brain barrier|negative regulation of BBB permeability|negative regulation of blood/brain barrier permeability http://purl.obolibrary.org/obo/GO_1905604 GO:2000663 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000663 GO:1905605 biolink:BiologicalProcess positive regulation of blood-brain barrier permeability Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. go.json activation of maintenance of permeability of BBB|activation of maintenance of permeability of blood-brain barrier|positive regulation of BBB permeability|positive regulation of blood/brain barrier permeability|up-regulation of BBB permeability|up-regulation of blood-brain barrier permeability|up-regulation of blood/brain barrier permeability|upregulation of BBB permeability|upregulation of blood-brain barrier permeability|upregulation of blood/brain barrier permeability http://purl.obolibrary.org/obo/GO_1905605 GO:2000664 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000664 GO:1905606 biolink:BiologicalProcess regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly. go.json regulation of presynapse biogenesis|regulation of presynaptic terminal assembly http://purl.obolibrary.org/obo/GO_1905606 goslim_synapse GO:1905607 biolink:BiologicalProcess negative regulation of presynapse assembly Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. go.json down regulation of presynapse assembly|down regulation of presynapse biogenesis|down regulation of presynaptic terminal assembly|down-regulation of presynapse assembly|down-regulation of presynapse biogenesis|down-regulation of presynaptic terminal assembly|downregulation of presynapse assembly|downregulation of presynapse biogenesis|downregulation of presynaptic terminal assembly|inhibition of presynapse assembly|inhibition of presynapse biogenesis|inhibition of presynaptic terminal assembly|negative regulation of presynapse biogenesis|negative regulation of presynaptic terminal assembly http://purl.obolibrary.org/obo/GO_1905607 GO:1905608 biolink:BiologicalProcess positive regulation of presynapse assembly Any process that activates or increases the frequency, rate or extent of presynapse assembly. go.json activation of presynapse assembly|activation of presynapse biogenesis|activation of presynaptic terminal assembly|positive regulation of presynapse biogenesis|positive regulation of presynaptic terminal assembly|up regulation of presynapse assembly|up regulation of presynapse biogenesis|up regulation of presynaptic terminal assembly|up-regulation of presynapse assembly|up-regulation of presynapse biogenesis|up-regulation of presynaptic terminal assembly|upregulation of presynapse assembly|upregulation of presynapse biogenesis|upregulation of presynaptic terminal assembly http://purl.obolibrary.org/obo/GO_1905608 GO:1905609 biolink:BiologicalProcess positive regulation of smooth muscle cell-matrix adhesion Any process that activates or increases the frequency, rate or extent of smooth muscle cell-matrix adhesion. go.json activation of smooth muscle cell-matrix adhesion|up regulation of smooth muscle cell-matrix adhesion|up-regulation of smooth muscle cell-matrix adhesion|upregulation of smooth muscle cell-matrix adhesion http://purl.obolibrary.org/obo/GO_1905609 GO:0051430 biolink:MolecularActivity corticotropin-releasing hormone receptor 1 binding Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. go.json CRHR1 binding|type 1 corticotropin releasing factor receptor binding|type 1 corticotropin releasing factor receptor ligand|type 1 corticotropin-releasing factor receptor binding http://purl.obolibrary.org/obo/GO_0051430 GO:0002427 biolink:BiologicalProcess mucosal tolerance induction Tolerance induction taking place in the mucosal tissues. go.json http://purl.obolibrary.org/obo/GO_0002427 GO:0002428 biolink:BiologicalProcess antigen processing and presentation of peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family. go.json peptide antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0002428 GO:0051431 biolink:MolecularActivity corticotropin-releasing hormone receptor 2 binding Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery. go.json CRHR2 binding|type 2 corticotropin releasing factor receptor binding|type 2 corticotropin releasing factor receptor ligand|type 2 corticotropin-releasing factor receptor binding http://purl.obolibrary.org/obo/GO_0051431 GO:0002429 biolink:BiologicalProcess immune response-activating cell surface receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell, leading to the activation or perpetuation of an immune response. go.json activation of immune response by cell surface receptor signaling pathway|immune response-activating cell surface receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002429 GO:0051445 biolink:BiologicalProcess regulation of meiotic cell cycle Any process that modulates the rate or extent of progression through the meiotic cell cycle. go.json meiotic cell cycle modulation|meiotic cell cycle regulation|meiotic cell cycle regulator|modulation of meiotic cell cycle progression|regulation of meiotic cell cycle progression|regulation of progression through meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051445 GO:0002434 biolink:BiologicalProcess immune complex clearance A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. go.json http://purl.obolibrary.org/obo/GO_0002434 GO:0002435 biolink:BiologicalProcess immune complex clearance by erythrocytes The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation. Wikipedia:Immune_complex go.json immune complex clearance by RBCs|immune complex clearance by red blood cells http://purl.obolibrary.org/obo/GO_0002435 GO:0051446 biolink:BiologicalProcess positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. go.json activation of progression through meiotic cell cycle|positive regulation of meiotic cell cycle progression|positive regulation of progression through meiotic cell cycle|stimulation of progression through meiotic cell cycle|up regulation of progression through meiotic cell cycle|up-regulation of progression through meiotic cell cycle|upregulation of progression through meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051446 GO:0051443 biolink:BiologicalProcess positive regulation of ubiquitin-protein transferase activity Any process that activates, maintains or increases the rate of ubiquitin transferase activity. go.json APC activation|APC activator|SCF complex activator|activation of ubiquitin transferase activity|anaphase promoting complex activator|anaphase-promoting complex activator|positive regulation of ubiquitin transferase activity|stimulation of ubiquitin transferase activity|ubiquitin transferase activator|up regulation of ubiquitin ligase activity|up-regulation of ubiquitin transferase activity|upregulation of ubiquitin transferase activity http://purl.obolibrary.org/obo/GO_0051443 gocheck_do_not_annotate GO:0002436 biolink:BiologicalProcess immune complex clearance by monocytes and macrophages The process of immune complex clearance by monocytes or macrophages. go.json http://purl.obolibrary.org/obo/GO_0002436 GO:0051444 biolink:BiologicalProcess negative regulation of ubiquitin-protein transferase activity Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. go.json APC inhibition|APC inhibitor|SCF complex inhibitor|anaphase promoting complex inhibition|anaphase promoting complex inhibitor|anaphase-promoting complex inhibition|anaphase-promoting complex inhibitor|down regulation of ubiquitin transferase activity|down-regulation of ubiquitin transferase activity|downregulation of ubiquitin transferase activity|inhibition of ubiquitin transferase activity|negative regulation of ubiquitin transferase activity|ubiquitin transferase inhibitor http://purl.obolibrary.org/obo/GO_0051444 gocheck_do_not_annotate GO:0002437 biolink:BiologicalProcess inflammatory response to antigenic stimulus An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. go.json http://purl.obolibrary.org/obo/GO_0002437 GO:0002430 biolink:BiologicalProcess complement receptor mediated signaling pathway The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway. go.json complement receptor mediated signalling pathway|immune response-regulating cell surface receptor signalling pathway http://purl.obolibrary.org/obo/GO_0002430 GO:0051449 biolink:MolecularActivity thyrotropin-releasing hormone binding Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system. go.json thyrotropin releasing hormone binding http://purl.obolibrary.org/obo/GO_0051449 GO:0002431 biolink:BiologicalProcess Fc receptor mediated stimulatory signaling pathway The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. go.json Fc receptor mediated stimulatory signalling pathway|Fc-receptor mediated stimulatory signaling pathway http://purl.obolibrary.org/obo/GO_0002431 GO:0051447 biolink:BiologicalProcess negative regulation of meiotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. go.json down regulation of progression through meiotic cell cycle|down-regulation of progression through meiotic cell cycle|downregulation of progression through meiotic cell cycle|inhibition of progression through meiotic cell cycle|negative regulation of meiotic cell cycle progression|negative regulation of progression through meiotic cell cycle http://purl.obolibrary.org/obo/GO_0051447 GO:0002432 biolink:BiologicalProcess granuloma formation The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic. go.json http://purl.obolibrary.org/obo/GO_0002432 GO:0002433 biolink:BiologicalProcess immune response-regulating cell surface receptor signaling pathway involved in phagocytosis An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. go.json immune response-regulating cell surface receptor signalling pathway involved in phagocytosis|phagocytosis triggered by activation of immune response cell surface activating receptor http://purl.obolibrary.org/obo/GO_0002433 GO:0051448 biolink:MolecularActivity gonadotropin-releasing hormone binding Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. go.json GnRH binding|gonadotrophin releasing hormone binding http://purl.obolibrary.org/obo/GO_0051448 GO:2000676 biolink:BiologicalProcess positive regulation of type B pancreatic cell apoptotic process Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. go.json positive regulation of pancreatic B cell apoptosis|positive regulation of pancreatic beta cell apoptosis|positive regulation of type B pancreatic cell apoptosis http://purl.obolibrary.org/obo/GO_2000676 GO:2000677 biolink:BiologicalProcess regulation of transcription regulatory region DNA binding Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. go.json http://purl.obolibrary.org/obo/GO_2000677 gocheck_do_not_annotate GO:2000678 biolink:BiologicalProcess negative regulation of transcription regulatory region DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. go.json http://purl.obolibrary.org/obo/GO_2000678 gocheck_do_not_annotate GO:2000679 biolink:BiologicalProcess positive regulation of transcription regulatory region DNA binding Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. go.json http://purl.obolibrary.org/obo/GO_2000679 gocheck_do_not_annotate GO:1905610 biolink:BiologicalProcess regulation of mRNA cap binding Any process that modulates the frequency, rate or extent of mRNA cap binding. go.json http://purl.obolibrary.org/obo/GO_1905610 gocheck_do_not_annotate GO:1905611 biolink:BiologicalProcess negative regulation of mRNA cap binding Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding. go.json down regulation of mRNA cap binding|down-regulation of mRNA cap binding|downregulation of mRNA cap binding|inhibition of mRNA cap binding http://purl.obolibrary.org/obo/GO_1905611 gocheck_do_not_annotate GO:2000670 biolink:BiologicalProcess positive regulation of dendritic cell apoptotic process Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process. go.json positive regulation of dendritic cell apoptosis http://purl.obolibrary.org/obo/GO_2000670 GO:2000671 biolink:BiologicalProcess regulation of motor neuron apoptotic process Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. go.json regulation of motoneuron apoptosis|regulation of motor neuron apoptosis http://purl.obolibrary.org/obo/GO_2000671 GO:1905612 biolink:BiologicalProcess positive regulation of mRNA cap binding Any process that activates or increases the frequency, rate or extent of mRNA cap binding. go.json activation of mRNA cap binding|up regulation of mRNA cap binding|up-regulation of mRNA cap binding|upregulation of mRNA cap binding http://purl.obolibrary.org/obo/GO_1905612 gocheck_do_not_annotate GO:1905613 biolink:BiologicalProcess regulation of developmental vegetative growth Any process that modulates the frequency, rate or extent of developmental vegetative growth. go.json http://purl.obolibrary.org/obo/GO_1905613 GO:2000672 biolink:BiologicalProcess negative regulation of motor neuron apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. go.json negative regulation of motoneuron apoptosis|negative regulation of motor neuron apoptosis http://purl.obolibrary.org/obo/GO_2000672 GO:1905614 biolink:BiologicalProcess negative regulation of developmental vegetative growth Any process that stops, prevents or reduces the frequency, rate or extent of developmental vegetative growth. go.json down regulation of developmental vegetative growth|down-regulation of developmental vegetative growth|downregulation of developmental vegetative growth|inhibition of developmental vegetative growth http://purl.obolibrary.org/obo/GO_1905614 GO:2000673 biolink:BiologicalProcess positive regulation of motor neuron apoptotic process Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. go.json positive regulation of motoneuron apoptosis|positive regulation of motor neuron apoptosis http://purl.obolibrary.org/obo/GO_2000673 GO:2000674 biolink:BiologicalProcess regulation of type B pancreatic cell apoptotic process Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. go.json regulation of pancreatic B cell apoptosis|regulation of pancreatic beta cell apoptosis|regulation of type B pancreatic cell apoptosis http://purl.obolibrary.org/obo/GO_2000674 GO:1905615 biolink:BiologicalProcess positive regulation of developmental vegetative growth Any process that activates or increases the frequency, rate or extent of developmental vegetative growth. go.json activation of developmental vegetative growth|up regulation of developmental vegetative growth|up-regulation of developmental vegetative growth|upregulation of developmental vegetative growth http://purl.obolibrary.org/obo/GO_1905615 GO:2000675 biolink:BiologicalProcess negative regulation of type B pancreatic cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. go.json negative regulation of pancreatic B cell apoptosis|negative regulation of pancreatic beta cell apoptosis|negative regulation of type B pancreatic cell apoptosis http://purl.obolibrary.org/obo/GO_2000675 GO:1905616 biolink:BiologicalProcess obsolete regulation of miRNA-mediated gene silencing by inhibition of translation OBSOLETE. Any process that modulates the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation. go.json regulation of down regulation of translation involved in gene silencing by miRNA|regulation of down-regulation of translation involved in gene silencing by miRNA|regulation of downregulation of translation involved in gene silencing by miRNA|regulation of gene silencing by miRNA, negative regulation of translation|regulation of inhibition of translation involved in gene silencing by miRNA|regulation of miRNA mediated inhibition of translation|regulation of miRNA-mediated gene silencing, negative regulation of translation|regulation of negative regulation of translation involved in gene silencing by microRNA True http://purl.obolibrary.org/obo/GO_1905616 GO:1905617 biolink:BiologicalProcess obsolete negative regulation of miRNA-mediated gene silencing by inhibition of translation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation. go.json down regulation of down regulation of translation involved in gene silencing by miRNA|down regulation of down-regulation of translation involved in gene silencing by miRNA|down regulation of downregulation of translation involved in gene silencing by miRNA|down regulation of gene silencing by miRNA, negative regulation of translation|down regulation of inhibition of translation involved in gene silencing by miRNA|down regulation of miRNA mediated inhibition of translation|down regulation of miRNA-mediated gene silencing, negative regulation of translation|down regulation of negative regulation of translation involved in gene silencing by microRNA|down-regulation of down regulation of translation involved in gene silencing by miRNA|down-regulation of down-regulation of translation involved in gene silencing by miRNA|down-regulation of downregulation of translation involved in gene silencing by miRNA|down-regulation of gene silencing by miRNA, negative regulation of translation|down-regulation of inhibition of translation involved in gene silencing by miRNA|down-regulation of miRNA mediated inhibition of translation|down-regulation of miRNA-mediated gene silencing, negative regulation of translation|down-regulation of negative regulation of translation involved in gene silencing by microRNA|downregulation of down regulation of translation involved in gene silencing by miRNA|downregulation of down-regulation of translation involved in gene silencing by miRNA|downregulation of downregulation of translation involved in gene silencing by miRNA|downregulation of gene silencing by miRNA, negative regulation of translation|downregulation of inhibition of translation involved in gene silencing by miRNA|downregulation of miRNA mediated inhibition of translation|downregulation of miRNA-mediated gene silencing, negative regulation of translation|downregulation of negative regulation of translation involved in gene silencing by microRNA|inhibition of down regulation of translation involved in gene silencing by miRNA|inhibition of down-regulation of translation involved in gene silencing by miRNA|inhibition of downregulation of translation involved in gene silencing by miRNA|inhibition of gene silencing by miRNA, negative regulation of translation|inhibition of inhibition of translation involved in gene silencing by miRNA|inhibition of miRNA mediated inhibition of translation|inhibition of miRNA-mediated gene silencing, negative regulation of translation|inhibition of negative regulation of translation involved in gene silencing by microRNA|negative regulation of down regulation of translation involved in gene silencing by miRNA|negative regulation of down-regulation of translation involved in gene silencing by miRNA|negative regulation of downregulation of translation involved in gene silencing by miRNA|negative regulation of gene silencing by miRNA, negative regulation of translation|negative regulation of inhibition of translation involved in gene silencing by miRNA|negative regulation of miRNA mediated inhibition of translation|negative regulation of miRNA-mediated gene silencing, negative regulation of translation|negative regulation of negative regulation of translation involved in gene silencing by microRNA True http://purl.obolibrary.org/obo/GO_1905617 GO:1905618 biolink:BiologicalProcess obsolete positive regulation of miRNA-mediated gene silencing by inhibition of translation OBSOLETE. Any process that activates or increases the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation. go.json activation of down regulation of translation involved in gene silencing by miRNA|activation of down-regulation of translation involved in gene silencing by miRNA|activation of downregulation of translation involved in gene silencing by miRNA|activation of gene silencing by miRNA, negative regulation of translation|activation of inhibition of translation involved in gene silencing by miRNA|activation of miRNA mediated inhibition of translation|activation of miRNA-mediated gene silencing, negative regulation of translation|activation of negative regulation of translation involved in gene silencing by microRNA|positive regulation of down regulation of translation involved in gene silencing by miRNA|positive regulation of down-regulation of translation involved in gene silencing by miRNA|positive regulation of downregulation of translation involved in gene silencing by miRNA|positive regulation of gene silencing by miRNA, negative regulation of translation|positive regulation of inhibition of translation involved in gene silencing by miRNA|positive regulation of miRNA mediated inhibition of translation|positive regulation of miRNA-mediated gene silencing, negative regulation of translation|positive regulation of negative regulation of translation involved in gene silencing by microRNA|up regulation of down regulation of translation involved in gene silencing by miRNA|up regulation of down-regulation of translation involved in gene silencing by miRNA|up regulation of downregulation of translation involved in gene silencing by miRNA|up regulation of gene silencing by miRNA, negative regulation of translation|up regulation of inhibition of translation involved in gene silencing by miRNA|up regulation of miRNA mediated inhibition of translation|up regulation of miRNA-mediated gene silencing, negative regulation of translation|up regulation of negative regulation of translation involved in gene silencing by microRNA|up-regulation of down regulation of translation involved in gene silencing by miRNA|up-regulation of down-regulation of translation involved in gene silencing by miRNA|up-regulation of downregulation of translation involved in gene silencing by miRNA|up-regulation of gene silencing by miRNA, negative regulation of translation|up-regulation of inhibition of translation involved in gene silencing by miRNA|up-regulation of miRNA mediated inhibition of translation|up-regulation of miRNA-mediated gene silencing, negative regulation of translation|up-regulation of negative regulation of translation involved in gene silencing by microRNA|upregulation of down regulation of translation involved in gene silencing by miRNA|upregulation of down-regulation of translation involved in gene silencing by miRNA|upregulation of downregulation of translation involved in gene silencing by miRNA|upregulation of gene silencing by miRNA, negative regulation of translation|upregulation of inhibition of translation involved in gene silencing by miRNA|upregulation of miRNA mediated inhibition of translation|upregulation of miRNA-mediated gene silencing, negative regulation of translation|upregulation of negative regulation of translation involved in gene silencing by microRNA True http://purl.obolibrary.org/obo/GO_1905618 GO:1905619 biolink:BiologicalProcess regulation of alpha-(1->3)-fucosyltransferase activity Any process that modulates the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. go.json regulation of alpha(1,3)-fucosyltransferase activity|regulation of alpha-(1,3)-fucosyltransferase activity|regulation of alpha-1,3-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_1905619 gocheck_do_not_annotate GO:0051441 biolink:BiologicalProcess obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle. go.json APC activation during meiotic cell cycle|activation of anaphase-promoting complex activity during meiotic cell cycle|activation of anaphase-promoting complex activity involved in meiotic cell cycle|activation of ubiquitin ligase activity during meiotic cell cycle|activation of ubiquitin ligase activity of APC during meiotic cell cycle|activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle|activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle|anaphase promoting complex activation during meiotic cell cycle|anaphase-promoting complex activation during meiotic cell cycle|meiotic APC activation|meiotic APC activator|meiotic SCF complex activator|meiotic anaphase promoting complex activation|meiotic anaphase promoting complex activator|meiotic anaphase-promoting complex activator|meiotic ubiquitin ligase activator|positive regulation of ubiquitin ligase activity during meiotic cell cycle|positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle|stimulation of ubiquitin ligase activity during meiotic cell cycle|up regulation of ubiquitin ligase activity during meiotic cell cycle|up-regulation of ubiquitin ligase activity during meiotic cell cycle|upregulation of ubiquitin ligase activity during meiotic cell cycle True http://purl.obolibrary.org/obo/GO_0051441 GO:0002438 biolink:BiologicalProcess acute inflammatory response to antigenic stimulus An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0002438 GO:0002439 biolink:BiologicalProcess chronic inflammatory response to antigenic stimulus A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual. go.json http://purl.obolibrary.org/obo/GO_0002439 GO:0051442 biolink:BiologicalProcess obsolete negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle. go.json APC inhibition during meiotic cell cycle|anaphase promoting complex inhibition during meiotic cell cycle|anaphase-promoting complex inhibition during meiotic cell cycle|down regulation of ubiquitin ligase activity during meiotic cell cycle|down-regulation of ubiquitin ligase activity during meiotic cell cycle|downregulation of ubiquitin ligase activity during meiotic cell cycle|inhibition of ubiquitin ligase activity during meiotic cell cycle|meiotic APC inhibition|meiotic APC inhibitor|meiotic SCF complex inhibitor|meiotic anaphase promoting complex inhibition|meiotic anaphase promoting complex inhibitor|meiotic anaphase-promoting complex inhibition|meiotic anaphase-promoting complex inhibitor|meiotic ubiquitin ligase inhibitor|negative regulation of ubiquitin ligase activity during meiotic cell cycle True http://purl.obolibrary.org/obo/GO_0051442 GO:0051440 biolink:BiologicalProcess obsolete regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle. go.json meiotic APC regulator|meiotic SCF complex regulator|meiotic anaphase-promoting complex regulator|meiotic ubiquitin ligase regulator|meiotic ubiquitin-protein ligase regulator|regulation of ubiquitin ligase activity during meiotic cell cycle|regulation of ubiquitin-protein ligase activity during meiotic cell cycle True http://purl.obolibrary.org/obo/GO_0051440 GO:0002401 biolink:BiologicalProcess tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT). go.json tolerance induction in MALT http://purl.obolibrary.org/obo/GO_0002401 GO:0051456 biolink:BiologicalProcess attachment of meiotic spindle microtubules to meiosis II kinetochore The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs. go.json attachment of meiotic spindle microtubules to kinetochore in meiosis II|attachment of spindle microtubules to kinetochore during meiosis II|meiotic bipolar attachment http://purl.obolibrary.org/obo/GO_0051456 GO:0051457 biolink:BiologicalProcess maintenance of protein location in nucleus Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. go.json maintenance of nuclear protein localization|maintenance of protein localization in nucleus|maintenance of protein location in cell nucleus|nuclear protein retention|nuclear protein sequestering|nuclear protein sequestration|protein retention in nucleus|protein sequestration in nucleus|protein storage in nucleus|protein-nuclear retention|sequestration of protein in nucleus|storage of protein in nucleus http://purl.obolibrary.org/obo/GO_0051457 GO:0002402 biolink:BiologicalProcess B cell tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells. go.json B cell tolerance induction in MALT http://purl.obolibrary.org/obo/GO_0002402 GO:0002403 biolink:BiologicalProcess T cell tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells. go.json T cell tolerance induction in MALT http://purl.obolibrary.org/obo/GO_0002403 GO:0051454 biolink:BiologicalProcess intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. go.json cell pH elevation|cellular alkalinization|elevation of cellular pH|intracellular alkalinization|pH elevation in cell http://purl.obolibrary.org/obo/GO_0051454 GO:0051455 biolink:BiologicalProcess spindle attachment to meiosis I kinetochore The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs. go.json attachment of spindle microtubules to kinetochore during meiosis I|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|attachment of spindle microtubules to kinetochore involved in meiosis I|monopolar attachment|sister kinetochore mono-orientation http://purl.obolibrary.org/obo/GO_0051455 GO:0002404 biolink:BiologicalProcess antigen sampling in mucosal-associated lymphoid tissue The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue. go.json antigen sampling in MALT|antigen transport in MALT|antigen transport in mucosal-associated lymphoid tissue http://purl.obolibrary.org/obo/GO_0002404 GO:0051458 biolink:BiologicalProcess corticotropin secretion The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. go.json ACTH secretion|adrenocorticotropic hormone secretion|adrenocorticotropin secretion|adrenotropic hormone secretion|adrenotropin secretion|corticotropic hormone secretion http://purl.obolibrary.org/obo/GO_0051458 GO:0051459 biolink:BiologicalProcess regulation of corticotropin secretion Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. go.json regulation of ACTH secretion|regulation of adrenocorticotropic hormone secretion|regulation of adrenocorticotropin secretion|regulation of adrenotropin hormone secretion|regulation of adrenotropin secretion|regulation of corticotropic hormone secretion http://purl.obolibrary.org/obo/GO_0051459 GO:0002400 biolink:BiologicalProcess tolerance induction in nasopharyngeal-associated lymphoid tissue Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT). go.json nasal tolerance|tolerance induction in NALT http://purl.obolibrary.org/obo/GO_0002400 GO:2000687 biolink:BiologicalProcess obsolete negative regulation of rubidium ion transmembrane transporter activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transmembrane transporter activity. go.json negative regulation of Rb+ transmembrane transporter activity|negative regulation of rubidium cation transmembrane transporter activity|negative regulation of rubidium transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_2000687 GO:2000688 biolink:BiologicalProcess obsolete positive regulation of rubidium ion transmembrane transporter activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transmembrane transporter activity. go.json positive regulation of Rb+ transmembrane transporter activity|positive regulation of rubidium cation transmembrane transporter activity|positive regulation of rubidium transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_2000688 GO:2000689 biolink:BiologicalProcess actomyosin contractile ring assembly actin filament organization An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis. go.json actin filament organisation of constriction ring assembly|actin filament organisation of contractile ring assembly|actin filament organisation of cytokinesis, actomyosin contractile ring assembly|actin filament organisation of cytokinesis, actomyosin contractile ring formation|actin filament organisation of cytokinesis, actomyosin ring biosynthesis|actin filament organisation of cytokinesis, actomyosin ring formation|actin filament organisation of cytokinesis, contractile ring assembly|actin filament organization involved in cytokinetic actomyosin contractile ring assembly|actin filament organization of constriction ring assembly|actin filament organization of contractile ring assembly|actin filament organization of cytokinesis, actomyosin contractile ring assembly|actin filament organization of cytokinesis, actomyosin contractile ring formation|actin filament organization of cytokinesis, actomyosin ring biosynthesis|actin filament organization of cytokinesis, actomyosin ring formation|actin filament organization of cytokinesis, contractile ring assembly|regulation of actin filament localization of constriction ring assembly|regulation of actin filament localization of contractile ring assembly|regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly|regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation|regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis|regulation of actin filament localization of cytokinesis, actomyosin ring formation|regulation of actin filament localization of cytokinesis, contractile ring assembly http://purl.obolibrary.org/obo/GO_2000689 GO:1905630 biolink:BiologicalProcess response to glyceraldehyde Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_1905630 GO:1905620 biolink:BiologicalProcess negative regulation of alpha-(1->3)-fucosyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. go.json down regulation of alpha(1,3)-fucosyltransferase activity|down regulation of alpha-(1,3)-fucosyltransferase activity|down regulation of alpha-(1->3)-fucosyltransferase activity|down regulation of alpha-1,3-fucosyltransferase activity|down-regulation of alpha(1,3)-fucosyltransferase activity|down-regulation of alpha-(1,3)-fucosyltransferase activity|down-regulation of alpha-(1->3)-fucosyltransferase activity|down-regulation of alpha-1,3-fucosyltransferase activity|downregulation of alpha(1,3)-fucosyltransferase activity|downregulation of alpha-(1,3)-fucosyltransferase activity|downregulation of alpha-(1->3)-fucosyltransferase activity|downregulation of alpha-1,3-fucosyltransferase activity|inhibition of alpha(1,3)-fucosyltransferase activity|inhibition of alpha-(1,3)-fucosyltransferase activity|inhibition of alpha-(1->3)-fucosyltransferase activity|inhibition of alpha-1,3-fucosyltransferase activity|negative regulation of alpha(1,3)-fucosyltransferase activity|negative regulation of alpha-(1,3)-fucosyltransferase activity|negative regulation of alpha-1,3-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_1905620 gocheck_do_not_annotate GO:1905621 biolink:BiologicalProcess positive regulation of alpha-(1->3)-fucosyltransferase activity Any process that activates or increases the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. go.json activation of alpha(1,3)-fucosyltransferase activity|activation of alpha-(1,3)-fucosyltransferase activity|activation of alpha-(1->3)-fucosyltransferase activity|activation of alpha-1,3-fucosyltransferase activity|positive regulation of alpha(1,3)-fucosyltransferase activity|positive regulation of alpha-(1,3)-fucosyltransferase activity|positive regulation of alpha-1,3-fucosyltransferase activity|up regulation of alpha(1,3)-fucosyltransferase activity|up regulation of alpha-(1,3)-fucosyltransferase activity|up regulation of alpha-(1->3)-fucosyltransferase activity|up regulation of alpha-1,3-fucosyltransferase activity|up-regulation of alpha(1,3)-fucosyltransferase activity|up-regulation of alpha-(1,3)-fucosyltransferase activity|up-regulation of alpha-(1->3)-fucosyltransferase activity|up-regulation of alpha-1,3-fucosyltransferase activity|upregulation of alpha(1,3)-fucosyltransferase activity|upregulation of alpha-(1,3)-fucosyltransferase activity|upregulation of alpha-(1->3)-fucosyltransferase activity|upregulation of alpha-1,3-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_1905621 gocheck_do_not_annotate GO:2000680 biolink:BiologicalProcess obsolete regulation of rubidium ion transport OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transport. go.json regulation of Rb+ transport|regulation of rubidium cation transport True http://purl.obolibrary.org/obo/GO_2000680 GO:2000681 biolink:BiologicalProcess obsolete negative regulation of rubidium ion transport OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transport. go.json negative regulation of Rb+ transport|negative regulation of rubidium cation transport True http://purl.obolibrary.org/obo/GO_2000681 GO:1905622 biolink:BiologicalProcess negative regulation of leaf development Any process that stops, prevents or reduces the frequency, rate or extent of leaf development. go.json down regulation of leaf development|down-regulation of leaf development|downregulation of leaf development|inhibition of leaf development http://purl.obolibrary.org/obo/GO_1905622 GO:1905623 biolink:BiologicalProcess positive regulation of leaf development Any process that activates or increases the frequency, rate or extent of leaf development. go.json activation of leaf development|up regulation of leaf development|up-regulation of leaf development|upregulation of leaf development http://purl.obolibrary.org/obo/GO_1905623 GO:2000682 biolink:BiologicalProcess obsolete positive regulation of rubidium ion transport OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transport. go.json positive regulation of Rb+ transport|positive regulation of rubidium cation transport True http://purl.obolibrary.org/obo/GO_2000682 GO:1905624 biolink:BiologicalProcess regulation of L-methionine import across plasma membrane Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905624 GO:2000683 biolink:BiologicalProcess regulation of cellular response to X-ray Any process that modulates the frequency, rate or extent of cellular response to X-ray. go.json regulation of cellular response to X-ray radiation stimulus http://purl.obolibrary.org/obo/GO_2000683 GO:1905625 biolink:BiologicalProcess negative regulation of L-methionine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-methionine import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905625 GO:2000684 biolink:BiologicalProcess negative regulation of cellular response to X-ray Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray. go.json negative regulation of cellular response to X-ray radiation stimulus http://purl.obolibrary.org/obo/GO_2000684 GO:2000685 biolink:BiologicalProcess positive regulation of cellular response to X-ray Any process that activates or increases the frequency, rate or extent of cellular response to X-ray. go.json positive regulation of cellular response to X-ray radiation stimulus http://purl.obolibrary.org/obo/GO_2000685 GO:1905626 biolink:BiologicalProcess positive regulation of L-methionine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-methionine import across plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1905626 GO:2000686 biolink:BiologicalProcess obsolete regulation of rubidium ion transmembrane transporter activity OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transmembrane transporter activity. go.json regulation of Rb+ transmembrane transporter activity|regulation of rubidium cation transmembrane transporter activity|regulation of rubidium transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_2000686 GO:1905627 biolink:BiologicalProcess regulation of serotonin biosynthetic process Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. go.json regulation of serotonin anabolism|regulation of serotonin biosynthesis|regulation of serotonin formation|regulation of serotonin synthesis http://purl.obolibrary.org/obo/GO_1905627 GO:1905628 biolink:BiologicalProcess negative regulation of serotonin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. go.json down regulation of serotonin anabolism|down regulation of serotonin biosynthesis|down regulation of serotonin biosynthetic process|down regulation of serotonin formation|down regulation of serotonin synthesis|down-regulation of serotonin anabolism|down-regulation of serotonin biosynthesis|down-regulation of serotonin biosynthetic process|down-regulation of serotonin formation|down-regulation of serotonin synthesis|downregulation of serotonin anabolism|downregulation of serotonin biosynthesis|downregulation of serotonin biosynthetic process|downregulation of serotonin formation|downregulation of serotonin synthesis|inhibition of serotonin anabolism|inhibition of serotonin biosynthesis|inhibition of serotonin biosynthetic process|inhibition of serotonin formation|inhibition of serotonin synthesis|negative regulation of serotonin anabolism|negative regulation of serotonin biosynthesis|negative regulation of serotonin formation|negative regulation of serotonin synthesis http://purl.obolibrary.org/obo/GO_1905628 GO:0002409 biolink:BiologicalProcess Langerhans cell chemotaxis The movement of a Langerhans cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002409 GO:1905629 biolink:BiologicalProcess positive regulation of serotonin biosynthetic process Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. go.json activation of serotonin anabolism|activation of serotonin biosynthesis|activation of serotonin biosynthetic process|activation of serotonin formation|activation of serotonin synthesis|positive regulation of serotonin anabolism|positive regulation of serotonin biosynthesis|positive regulation of serotonin formation|positive regulation of serotonin synthesis|up regulation of serotonin anabolism|up regulation of serotonin biosynthesis|up regulation of serotonin biosynthetic process|up regulation of serotonin formation|up regulation of serotonin synthesis|up-regulation of serotonin anabolism|up-regulation of serotonin biosynthesis|up-regulation of serotonin biosynthetic process|up-regulation of serotonin formation|up-regulation of serotonin synthesis|upregulation of serotonin anabolism|upregulation of serotonin biosynthesis|upregulation of serotonin biosynthetic process|upregulation of serotonin formation|upregulation of serotonin synthesis http://purl.obolibrary.org/obo/GO_1905629 GO:0051452 biolink:BiologicalProcess intracellular pH reduction Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. go.json cell pH reduction|cellular acidification|intracellular acidification|reduction of cellular pH|reduction of pH in cell http://purl.obolibrary.org/obo/GO_0051452 GO:0002405 biolink:BiologicalProcess antigen sampling by dendritic cells in mucosal-associated lymphoid tissue The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue. go.json antigen sampling by dendritic cells in MALT http://purl.obolibrary.org/obo/GO_0002405 GO:0051453 biolink:BiologicalProcess regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. go.json cell pH regulation|cellular pH regulation|pH regulation in cell|regulation of cell pH http://purl.obolibrary.org/obo/GO_0051453 GO:0002406 biolink:BiologicalProcess antigen sampling by M cells in mucosal-associated lymphoid tissue The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue. go.json antigen sampling by M cells in MALT http://purl.obolibrary.org/obo/GO_0002406 GO:0051450 biolink:BiologicalProcess myoblast proliferation The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0051450 GO:0002407 biolink:BiologicalProcess dendritic cell chemotaxis The movement of a dendritic cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002407 GO:0002408 biolink:BiologicalProcess myeloid dendritic cell chemotaxis The movement of a myeloid dendritic cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002408 GO:0051451 biolink:BiologicalProcess myoblast migration The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0051451 GO:0002412 biolink:BiologicalProcess antigen transcytosis by M cells in mucosal-associated lymphoid tissue The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT. go.json antigen transcytosis by M cells in MALT|antigen transport by M cells in MALT|antigen transport by M cells in mucosal-associated lymphoid tissue http://purl.obolibrary.org/obo/GO_0002412 GO:0051467 biolink:BiologicalProcess detection of steroid hormone stimulus The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0051467 GO:0002413 biolink:BiologicalProcess tolerance induction to tumor cell A process of tolerance induction which leads to immunological tolerance of a tumor. go.json http://purl.obolibrary.org/obo/GO_0002413 GO:0051468 biolink:BiologicalProcess detection of glucocorticoid hormone stimulus The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. go.json http://purl.obolibrary.org/obo/GO_0051468 GO:0051465 biolink:BiologicalProcess negative regulation of corticotropin-releasing hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell. go.json down regulation of corticotropin-releasing hormone secretion|down-regulation of corticotropin-releasing hormone secretion|downregulation of corticotropin-releasing hormone secretion|inhibition of corticotropin-releasing hormone secretion|negative regulation of CRF secretion|negative regulation of CRH secretion|negative regulation of corticotropin-releasing factor secretion http://purl.obolibrary.org/obo/GO_0051465 GO:0002414 biolink:BiologicalProcess immunoglobulin transcytosis in epithelial cells The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other. go.json http://purl.obolibrary.org/obo/GO_0002414 GO:0002415 biolink:BiologicalProcess immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa. go.json antibody transcytosis mediated by pIgR|immunoglobulin transcytosis mediated by pIgR http://purl.obolibrary.org/obo/GO_0002415 GO:0051466 biolink:BiologicalProcess positive regulation of corticotropin-releasing hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell. go.json activation of corticotropin-releasing hormone secretion|positive regulation of CRF secretion|positive regulation of CRH secretion|positive regulation of corticotropin-releasing factor secretion|stimulation of corticotropin-releasing hormone secretion|up regulation of corticotropin-releasing hormone secretion|up-regulation of corticotropin-releasing hormone secretion|upregulation of corticotropin-releasing hormone secretion http://purl.obolibrary.org/obo/GO_0051466 GO:0002410 biolink:BiologicalProcess plasmacytoid dendritic cell chemotaxis The movement of a plasmacytoid dendritic cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0002410 GO:0051469 biolink:BiologicalProcess vesicle fusion with vacuole The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. go.json heterotypic vacuole fusion (non-autophagic)|heterotypic vacuole fusion, non-autophagic http://purl.obolibrary.org/obo/GO_0051469 GO:0002411 biolink:BiologicalProcess T cell tolerance induction to tumor cell A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor. go.json http://purl.obolibrary.org/obo/GO_0002411 GO:2000698 biolink:BiologicalProcess positive regulation of epithelial cell differentiation involved in kidney development Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development. go.json http://purl.obolibrary.org/obo/GO_2000698 GO:2000699 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in ureteric bud formation The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct. go.json FGF receptor signaling pathway of ureteric bud formation|FGF receptor signalling pathway of ureteric bud formation|FGFR signaling pathway of ureteric bud formation|fibroblast growth factor receptor signaling pathway of ureteric bud formation|fibroblast growth factor receptor signalling pathway of ureteric bud formation http://purl.obolibrary.org/obo/GO_2000699 GO:1905640 biolink:BiologicalProcess response to acetaldehyde Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_1905640 GO:1905641 biolink:BiologicalProcess cellular response to acetaldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_1905641 GO:1905631 biolink:BiologicalProcess cellular response to glyceraldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_1905631 GO:2000690 biolink:BiologicalProcess regulation of cardiac muscle cell myoblast differentiation Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. go.json regulation of cardiac myoblast differentiation|regulation of myocardial precursor cell differentiation http://purl.obolibrary.org/obo/GO_2000690 GO:2000691 biolink:BiologicalProcess negative regulation of cardiac muscle cell myoblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. go.json negative regulation of cardiac myoblast differentiation|negative regulation of myocardial precursor cell differentiation http://purl.obolibrary.org/obo/GO_2000691 GO:1905632 biolink:BiologicalProcess protein localization to euchromatin A process in which a protein is transported to, or maintained in, a location within an euchromatin. go.json protein localisation in euchromatin|protein localisation to euchromatin|protein localization in euchromatin http://purl.obolibrary.org/obo/GO_1905632 GO:1905633 biolink:BiologicalProcess establishment of protein localization to euchromatin The directed movement of a protein to a specific location in an euchromatin. go.json establishment of protein localisation in euchromatin|establishment of protein localisation to euchromatin|establishment of protein localization in euchromatin http://purl.obolibrary.org/obo/GO_1905633 GO:2000692 biolink:BiologicalProcess negative regulation of seed maturation Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation. go.json http://purl.obolibrary.org/obo/GO_2000692 GO:1905634 biolink:BiologicalProcess regulation of protein localization to chromatin Any process that modulates the frequency, rate or extent of protein localization to chromatin. go.json regulation of protein localisation to chromatin http://purl.obolibrary.org/obo/GO_1905634 GO:2000693 biolink:BiologicalProcess positive regulation of seed maturation Any process that activates or increases the frequency, rate or extent of seed maturation. go.json http://purl.obolibrary.org/obo/GO_2000693 GO:1905635 biolink:BiologicalProcess FACT complex assembly The aggregation, arrangement and bonding together of a set of components to form a FACT complex. go.json FACT complex formation|Facilitates chromatin transcription complex assembly|Facilitates chromatin transcription complex formation http://purl.obolibrary.org/obo/GO_1905635 GO:2000694 biolink:BiologicalProcess regulation of phragmoplast microtubule organization Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization. go.json regulation of phragmoplast microtubule cytoskeleton organization|regulation of phragmoplast microtubule organisation http://purl.obolibrary.org/obo/GO_2000694 GO:1905636 biolink:BiologicalProcess positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. go.json activation of RNA polymerase II regulatory region sequence-specific DNA binding|up regulation of RNA polymerase II regulatory region sequence-specific DNA binding|up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding|upregulation of RNA polymerase II regulatory region sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_1905636 gocheck_do_not_annotate GO:2000695 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2000695 GO:1905637 biolink:BiologicalProcess regulation of mitochondrial mRNA catabolic process Any process that modulates the frequency, rate or extent of mitochondrial mRNA catabolic process. go.json http://purl.obolibrary.org/obo/GO_1905637 GO:2000696 biolink:BiologicalProcess regulation of epithelial cell differentiation involved in kidney development Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. go.json http://purl.obolibrary.org/obo/GO_2000696 GO:1905638 biolink:BiologicalProcess negative regulation of mitochondrial mRNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial mRNA catabolic process. go.json down regulation of mitochondrial mRNA catabolic process|down-regulation of mitochondrial mRNA catabolic process|downregulation of mitochondrial mRNA catabolic process|inhibition of mitochondrial mRNA catabolic process http://purl.obolibrary.org/obo/GO_1905638 GO:2000697 biolink:BiologicalProcess negative regulation of epithelial cell differentiation involved in kidney development Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development. go.json http://purl.obolibrary.org/obo/GO_2000697 GO:1905639 biolink:BiologicalProcess positive regulation of mitochondrial mRNA catabolic process Any process that activates or increases the frequency, rate or extent of mitochondrial mRNA catabolic process. go.json activation of mitochondrial mRNA catabolic process|up regulation of mitochondrial mRNA catabolic process|up-regulation of mitochondrial mRNA catabolic process|upregulation of mitochondrial mRNA catabolic process http://purl.obolibrary.org/obo/GO_1905639 GO:0051460 biolink:BiologicalProcess negative regulation of corticotropin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. go.json down regulation of adrenocorticotropin secretion|down-regulation of adrenocorticotropin secretion|downregulation of adrenocorticotropin secretion|inhibition of adrenocorticotropin secretion|negative regulation of ACTH secretion|negative regulation of adrenocorticotropic hormone secretion|negative regulation of adrenocorticotropin secretion|negative regulation of adrenotropic hormone secretion|negative regulation of adrenotropin secretion|negative regulation of corticotropic hormone secretion http://purl.obolibrary.org/obo/GO_0051460 GO:0051463 biolink:BiologicalProcess negative regulation of cortisol secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell. go.json down regulation of cortisol secretion|down-regulation of cortisol secretion|downregulation of cortisol secretion|inhibition of cortisol secretion http://purl.obolibrary.org/obo/GO_0051463 GO:0002416 biolink:BiologicalProcess IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals. go.json IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor|IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor http://purl.obolibrary.org/obo/GO_0002416 GO:0051464 biolink:BiologicalProcess positive regulation of cortisol secretion Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell. go.json activation of cortisol secretion|stimulation of cortisol secretion|up regulation of cortisol secretion|up-regulation of cortisol secretion|upregulation of cortisol secretion http://purl.obolibrary.org/obo/GO_0051464 GO:0002417 biolink:BiologicalProcess B cell antigen processing and presentation mediated by B cell receptor uptake of antigen B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor. go.json B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen|B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen|B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen http://purl.obolibrary.org/obo/GO_0002417 GO:0051461 biolink:BiologicalProcess positive regulation of corticotropin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell. go.json activation of adrenocorticotropin secretion|positive regulation of ACTH secretion|positive regulation of adrenocorticotropic hormone secretion|positive regulation of adrenocorticotropin secretion|positive regulation of adrenotropic hormone secretion|positive regulation of adrenotropin secretion|positive regulation of corticotropic hormone secretion|stimulation of adrenocorticotropin secretion|up regulation of adrenocorticotropin secretion|up-regulation of adrenocorticotropin secretion|upregulation of adrenocorticotropin secretion http://purl.obolibrary.org/obo/GO_0051461 GO:0002418 biolink:BiologicalProcess immune response to tumor cell An immune system process that functions in the response of an organism to a tumor cell. go.json http://purl.obolibrary.org/obo/GO_0002418 GO:0002419 biolink:BiologicalProcess T cell mediated cytotoxicity directed against tumor cell target The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. go.json T lymphocyte mediated cytotoxicity directed against tumor cell target|T-cell mediated cytotoxicity directed against tumor cell target|T-lymphocyte mediated cytotoxicity directed against tumor cell target http://purl.obolibrary.org/obo/GO_0002419 GO:0051462 biolink:BiologicalProcess regulation of cortisol secretion Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell. go.json http://purl.obolibrary.org/obo/GO_0051462 GO:0002489 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway|TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway|endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent http://purl.obolibrary.org/obo/GO_0002489 GO:0002485 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules. go.json TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway|endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent http://purl.obolibrary.org/obo/GO_0002485 GO:0002486 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules. go.json TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway|endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent http://purl.obolibrary.org/obo/GO_0002486 GO:0002487 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules. go.json endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway http://purl.obolibrary.org/obo/GO_0002487 GO:0002488 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway http://purl.obolibrary.org/obo/GO_0002488 GO:0002481 biolink:BiologicalProcess antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib|TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib|exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent http://purl.obolibrary.org/obo/GO_0002481 GO:0002482 biolink:BiologicalProcess antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib|TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib|exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent http://purl.obolibrary.org/obo/GO_0002482 GO:0002483 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. go.json endogenous peptide antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002483 GO:0002484 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules. go.json endogenous peptide antigen processing and presentation via MHC class I via ER pathway http://purl.obolibrary.org/obo/GO_0002484 GO:0002480 biolink:BiologicalProcess antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules. go.json TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I|TAP-independent exogenous peptide antigen processing and presentation via MHC class I|cross presentation|cross-presentation|exogenous peptide antigen processing and presentation via MHC class I, TAP-independent http://purl.obolibrary.org/obo/GO_0002480 GO:0002496 biolink:BiologicalProcess proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002496 GO:0002497 biolink:BiologicalProcess proteasomal proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation. go.json http://purl.obolibrary.org/obo/GO_0002497 GO:0002498 biolink:BiologicalProcess proteolysis within endoplasmic reticulum associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation. go.json ER proteolysis associated with antigen processing and presentation|endoplasmic reticulum proteolysis associated with antigen processing and presentation|proteolysis within ER associated with antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002498 GO:0002499 biolink:BiologicalProcess proteolysis within endosome associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation. go.json endosomal proteolysis associated with antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002499 GO:0002492 biolink:BiologicalProcess peptide antigen assembly with MHC class Ib protein complex The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json http://purl.obolibrary.org/obo/GO_0002492 GO:0002493 biolink:BiologicalProcess lipid antigen assembly with MHC class Ib protein complex The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family. go.json http://purl.obolibrary.org/obo/GO_0002493 GO:0002494 biolink:BiologicalProcess lipid antigen transport The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0002494 GO:0002495 biolink:BiologicalProcess antigen processing and presentation of peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. go.json peptide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002495 GO:0002490 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. go.json TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway|TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway|endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent http://purl.obolibrary.org/obo/GO_0002490 GO:0002491 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. go.json endogenous peptide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0002491 GO:0021780 biolink:BiologicalProcess glial cell fate specification The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0021780 GO:0031108 biolink:BiologicalProcess holo-[acyl-carrier-protein] biosynthetic process The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]. go.json holo-[acyl-carrier protein] biosynthesis|holo-[acyl-carrier-protein] anabolism|holo-[acyl-carrier-protein] biosynthesis|holo-[acyl-carrier-protein] formation|holo-[acyl-carrier-protein] synthesis http://purl.obolibrary.org/obo/GO_0031108 GO:0021781 biolink:BiologicalProcess glial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. go.json http://purl.obolibrary.org/obo/GO_0021781 GO:0031109 biolink:BiologicalProcess microtubule polymerization or depolymerization Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. go.json microtubule dynamics http://purl.obolibrary.org/obo/GO_0031109 GO:0021782 biolink:BiologicalProcess glial cell development The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0021782 GO:0031106 biolink:BiologicalProcess septin ring organization Control of the formation, spatial distribution, and breakdown of the septin ring. go.json septin ring organisation http://purl.obolibrary.org/obo/GO_0031106 GO:0021783 biolink:BiologicalProcess preganglionic parasympathetic fiber development The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion. go.json http://purl.obolibrary.org/obo/GO_0021783 GO:0021784 biolink:BiologicalProcess postganglionic parasympathetic fiber development The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. go.json http://purl.obolibrary.org/obo/GO_0021784 GO:0031107 biolink:BiologicalProcess septin ring disassembly The controlled breakdown of a septin ring. go.json http://purl.obolibrary.org/obo/GO_0031107 GO:0006148 biolink:BiologicalProcess inosine catabolic process The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. go.json inosine breakdown|inosine catabolism|inosine degradation http://purl.obolibrary.org/obo/GO_0006148 GO:0021785 biolink:BiologicalProcess branchiomotor neuron axon guidance The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json BMN axon guidance|branchial motor axon guidance|special visceral motor neuron axon guidance http://purl.obolibrary.org/obo/GO_0021785 GO:0031104 biolink:BiologicalProcess dendrite regeneration The regrowth of dendrites in response to their loss or damage. go.json http://purl.obolibrary.org/obo/GO_0031104 GO:0031105 biolink:CellularComponent septin complex A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. go.json http://purl.obolibrary.org/obo/GO_0031105 goslim_pir GO:0006149 biolink:BiologicalProcess deoxyinosine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside. go.json deoxyinosine breakdown|deoxyinosine catabolism|deoxyinosine degradation http://purl.obolibrary.org/obo/GO_0006149 GO:0021786 biolink:BiologicalProcess branchiomotor neuron axon guidance in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json http://purl.obolibrary.org/obo/GO_0021786 GO:0006146 biolink:BiologicalProcess adenine catabolic process The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. go.json adenine breakdown|adenine catabolism|adenine degradation http://purl.obolibrary.org/obo/GO_0006146 GO:0045754 biolink:BiologicalProcess positive regulation of acetate catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. go.json activation of acetate catabolic process|positive regulation of acetate breakdown|positive regulation of acetate catabolism|positive regulation of acetate degradation|stimulation of acetate catabolic process|up regulation of acetate catabolic process|up-regulation of acetate catabolic process|upregulation of acetate catabolic process http://purl.obolibrary.org/obo/GO_0045754 GO:0045755 biolink:BiologicalProcess negative regulation of initiation of acetate catabolic process by acetate Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. go.json down regulation of initiation of acetate catabolic process by acetate|down-regulation of initiation of acetate catabolic process by acetate|downregulation of initiation of acetate catabolic process by acetate|inhibition of initiation of acetate catabolic process by acetate|negative regulation of initiation of acetate breakdown by acetate|negative regulation of initiation of acetate degradation by acetate http://purl.obolibrary.org/obo/GO_0045755 GO:0006147 biolink:BiologicalProcess guanine catabolic process The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. go.json guanine breakdown|guanine catabolism|guanine degradation http://purl.obolibrary.org/obo/GO_0006147 GO:0006144 biolink:BiologicalProcess purine nucleobase metabolic process The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. go.json purine base metabolic process|purine base metabolism|purine metabolic process|purine metabolism http://purl.obolibrary.org/obo/GO_0006144 GO:0045752 biolink:BiologicalProcess positive regulation of Toll signaling pathway Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway. go.json activation of Toll signaling pathway|positive regulation of Tl signaling pathway|positive regulation of Tl signalling pathway|stimulation of Toll signaling pathway|up regulation of Toll signaling pathway|up-regulation of Toll signaling pathway|upregulation of Toll signaling pathway http://purl.obolibrary.org/obo/GO_0045752 GO:0006145 biolink:BiologicalProcess purine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. go.json purine base breakdown|purine base catabolic process|purine base catabolism|purine base degradation http://purl.obolibrary.org/obo/GO_0006145 GO:0045753 biolink:BiologicalProcess negative regulation of acetate catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. go.json down regulation of acetate catabolic process|down-regulation of acetate catabolic process|downregulation of acetate catabolic process|inhibition of acetate catabolic process|negative regulation of acetate breakdown|negative regulation of acetate catabolism|negative regulation of acetate degradation http://purl.obolibrary.org/obo/GO_0045753 GO:0045750 biolink:BiologicalProcess obsolete positive regulation of S phase of mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity. go.json activation of S phase of mitotic cell cycle|positive regulation of S phase of mitotic cell cycle|positive regulation of S-phase of mitotic cell cycle|stimulation of S phase of mitotic cell cycle|up regulation of S phase of mitotic cell cycle|up-regulation of S phase of mitotic cell cycle|upregulation of S phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0045750 GO:0006142 biolink:BiologicalProcess regulation of pyrimidine nucleobase metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases. go.json regulation of pyrimidine base metabolic process|regulation of pyrimidine base metabolism http://purl.obolibrary.org/obo/GO_0006142 GO:0006143 biolink:BiologicalProcess obsolete purine metabolic process OBSOLETE. (Was not defined before being made obsolete). go.json purine metabolic process True http://purl.obolibrary.org/obo/GO_0006143 GO:0045751 biolink:BiologicalProcess negative regulation of Toll signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway. go.json down regulation of Toll signaling pathway|down-regulation of Toll signaling pathway|downregulation of Toll signaling pathway|inhibition of Toll signaling pathway|negative regulation of Tl signaling pathway|negative regulation of Tl signalling pathway http://purl.obolibrary.org/obo/GO_0045751 GO:0070709 biolink:BiologicalProcess RNA guanosine insertion The modification of an RNA molecule by insertion of a guanosine nucleotide. go.json RNA G insertion http://purl.obolibrary.org/obo/GO_0070709 GO:0006140 biolink:BiologicalProcess regulation of nucleotide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. go.json regulation of nucleotide metabolism http://purl.obolibrary.org/obo/GO_0006140 GO:0006141 biolink:BiologicalProcess regulation of purine nucleobase metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines. go.json regulation of purine base metabolic process|regulation of purine base metabolism http://purl.obolibrary.org/obo/GO_0006141 GO:0070718 biolink:CellularComponent alphaPDGFR-SHP-2 complex A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway. go.json PDGFRA-SHP-2 complex, PDGF stimulated http://purl.obolibrary.org/obo/GO_0070718 GO:0006150 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006150 GO:0070719 biolink:CellularComponent alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway. go.json PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated http://purl.obolibrary.org/obo/GO_0070719 GO:0070716 biolink:BiologicalProcess mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication. go.json mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0070716 GO:0070717 biolink:MolecularActivity poly-purine tract binding Binding to a stretch of purines (adenine or guanine) in an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070717 GO:0070714 biolink:BiologicalProcess RNA guanosine-uridine insertion The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide. go.json RNA GU insertion http://purl.obolibrary.org/obo/GO_0070714 GO:0045758 biolink:BiologicalProcess obsolete positive regulation of actin polymerization and/or depolymerization OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization. go.json positive regulation of actin polymerization and/or depolymerization True http://purl.obolibrary.org/obo/GO_0045758 GO:0045759 biolink:BiologicalProcess negative regulation of action potential Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json down regulation of action potential|down-regulation of action potential|downregulation of action potential|inhibition of action potential http://purl.obolibrary.org/obo/GO_0045759 GO:0070715 biolink:BiologicalProcess sodium-dependent organic cation transport The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0070715 GO:0045756 biolink:BiologicalProcess positive regulation of initiation of acetate catabolic process by acetate Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. go.json activation of initiation of acetate catabolic process by acetate|positive regulation of initiation of acetate breakdown by acetate|positive regulation of initiation of acetate degradation by acetate|stimulation of initiation of acetate catabolic process by acetate|up regulation of initiation of acetate catabolic process by acetate|up-regulation of initiation of acetate catabolic process by acetate|upregulation of initiation of acetate catabolic process by acetate http://purl.obolibrary.org/obo/GO_0045756 GO:0070712 biolink:BiologicalProcess RNA cytidine-uridine insertion The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide. go.json RNA CU insertion http://purl.obolibrary.org/obo/GO_0070712 GO:0070713 biolink:BiologicalProcess RNA guanosine-cytidine insertion The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide. go.json RNA GC insertion http://purl.obolibrary.org/obo/GO_0070713 GO:0045757 biolink:BiologicalProcess obsolete negative regulation of actin polymerization and/or depolymerization OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization. go.json negative regulation of actin polymerization and/or depolymerization True http://purl.obolibrary.org/obo/GO_0045757 GO:0070710 biolink:BiologicalProcess RNA uridine deletion The modification of an RNA molecule by removal of a uridine nucleotide. go.json RNA U deletion|RNA uridine excision http://purl.obolibrary.org/obo/GO_0070710 GO:0021787 biolink:BiologicalProcess chemorepulsion of branchiomotor neuron axon in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json negative chemotaxis of branchiomotor neuron axon in neural tube http://purl.obolibrary.org/obo/GO_0021787 GO:0031102 biolink:BiologicalProcess neuron projection regeneration The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. go.json neurite regeneration http://purl.obolibrary.org/obo/GO_0031102 GO:0070711 biolink:BiologicalProcess RNA adenosine-uridine insertion The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide. go.json RNA AU insertion http://purl.obolibrary.org/obo/GO_0070711 GO:0031103 biolink:BiologicalProcess axon regeneration The regrowth of axons following their loss or damage. go.json http://purl.obolibrary.org/obo/GO_0031103 GO:0021788 biolink:BiologicalProcess chemoattraction of branchiomotor neuron axon in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json positive chemotaxis of branchiomotor neuron axon in neural tube http://purl.obolibrary.org/obo/GO_0021788 GO:0021789 biolink:BiologicalProcess branchiomotor neuron axon guidance in branchial arch mesenchyme The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json http://purl.obolibrary.org/obo/GO_0021789 GO:0031100 biolink:BiologicalProcess animal organ regeneration The regrowth of a lost or destroyed animal organ. go.json http://purl.obolibrary.org/obo/GO_0031100 GO:0031101 biolink:BiologicalProcess fin regeneration The regrowth of fin tissue following its loss or destruction. go.json http://purl.obolibrary.org/obo/GO_0031101 GO:0021770 biolink:BiologicalProcess parahippocampal gyrus development The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex. Wikipedia:parahippocampal_gyrus go.json hippocampal gyrus development http://purl.obolibrary.org/obo/GO_0021770 GO:0021771 biolink:BiologicalProcess lateral geniculate nucleus development The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina. go.json LGN development http://purl.obolibrary.org/obo/GO_0021771 GO:0021772 biolink:BiologicalProcess olfactory bulb development The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. go.json http://purl.obolibrary.org/obo/GO_0021772 GO:0021773 biolink:BiologicalProcess striatal medium spiny neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum. go.json medium-sized spiny neuron differentiation|striatal MSN differentiation http://purl.obolibrary.org/obo/GO_0021773 GO:0006159 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006159 GO:0021774 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. go.json retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification http://purl.obolibrary.org/obo/GO_0021774 GO:0021775 biolink:BiologicalProcess smoothened signaling pathway involved in ventral spinal cord interneuron specification The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. go.json hedgehog signaling pathway involved in ventral spinal cord interneuron specification|hh signaling pathway involved in ventral spinal cord interneuron specification|smoothened signalling pathway involved in ventral spinal cord interneuron specification http://purl.obolibrary.org/obo/GO_0021775 GO:0045765 biolink:BiologicalProcess regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0045765 GO:0006157 biolink:BiologicalProcess deoxyadenosine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. go.json deoxyadenosine breakdown|deoxyadenosine catabolism|deoxyadenosine degradation|deoxyadenosine phosphorolysis http://purl.obolibrary.org/obo/GO_0006157 GO:0045766 biolink:BiologicalProcess positive regulation of angiogenesis Any process that activates or increases angiogenesis. go.json activation of angiogenesis|stimulation of angiogenesis|up regulation of angiogenesis|up-regulation of angiogenesis|upregulation of angiogenesis http://purl.obolibrary.org/obo/GO_0045766 GO:0006158 biolink:BiologicalProcess obsolete deoxyadenosine deaminase reaction OBSOLETE. (Was not defined before being made obsolete). go.json deoxyadenosine deaminase reaction True http://purl.obolibrary.org/obo/GO_0006158 GO:0045763 biolink:BiologicalProcess negative regulation of cellular amino acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. go.json down regulation of amino acid metabolic process|down-regulation of amino acid metabolic process|downregulation of amino acid metabolic process|inhibition of amino acid metabolic process|negative regulation of amino acid metabolism http://purl.obolibrary.org/obo/GO_0045763 GO:0006155 biolink:BiologicalProcess obsolete adenosine deaminase reaction OBSOLETE. (Was not defined before being made obsolete). go.json adenosine deaminase reaction True http://purl.obolibrary.org/obo/GO_0006155 GO:0006156 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006156 GO:0045764 biolink:BiologicalProcess positive regulation of amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. go.json activation of amino acid metabolic process|positive regulation of amino acid metabolism|positive regulation of cellular amino acid metabolic process|stimulation of amino acid metabolic process|up regulation of amino acid metabolic process|up-regulation of amino acid metabolic process|upregulation of amino acid metabolic process http://purl.obolibrary.org/obo/GO_0045764 GO:0045761 biolink:BiologicalProcess regulation of adenylate cyclase activity Any process that modulates the frequency, rate or extent of adenylate cyclase activity. go.json adenylate cyclase regulator|regulation of adenylyl cyclase activity http://purl.obolibrary.org/obo/GO_0045761 gocheck_do_not_annotate GO:0006153 biolink:BiologicalProcess obsolete purine nucleosidase reaction OBSOLETE. (Was not defined before being made obsolete). go.json purine nucleosidase reaction True http://purl.obolibrary.org/obo/GO_0006153 GO:0045762 biolink:BiologicalProcess positive regulation of adenylate cyclase activity Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. go.json adenylate cyclase activator|positive regulation of adenylyl cyclase activity|stimulation of adenylate cyclase activity|up regulation of adenylate cyclase activity|up-regulation of adenylate cyclase activity|upregulation of adenylate cyclase activity http://purl.obolibrary.org/obo/GO_0045762 gocheck_do_not_annotate GO:0006154 biolink:BiologicalProcess adenosine catabolic process The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. go.json adenosine breakdown|adenosine catabolism|adenosine degradation|adenosine phosphorolysis http://purl.obolibrary.org/obo/GO_0006154 GO:0006151 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006151 GO:0045760 biolink:BiologicalProcess positive regulation of action potential Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json activation of action potential|stimulation of action potential|up regulation of action potential|up-regulation of action potential|upregulation of action potential http://purl.obolibrary.org/obo/GO_0045760 GO:0006152 biolink:BiologicalProcess purine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json purine nucleoside breakdown|purine nucleoside catabolism|purine nucleoside degradation http://purl.obolibrary.org/obo/GO_0006152 GO:0006160 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006160 GO:0070707 biolink:BiologicalProcess RNA dinucleotide insertion The modification of an RNA molecule by insertion of a dinucleotide. go.json http://purl.obolibrary.org/obo/GO_0070707 GO:0070708 biolink:BiologicalProcess RNA cytidine insertion The modification of an RNA molecule by insertion of a cytidine nucleotide. go.json RNA C insertion http://purl.obolibrary.org/obo/GO_0070708 GO:0006161 biolink:BiologicalProcess deoxyguanosine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. go.json deoxyguanosine breakdown|deoxyguanosine catabolism|deoxyguanosine degradation http://purl.obolibrary.org/obo/GO_0006161 GO:0070705 biolink:BiologicalProcess RNA nucleotide insertion The modification of an RNA molecule by insertion of one or more nucleotides. go.json http://purl.obolibrary.org/obo/GO_0070705 GO:0070706 biolink:BiologicalProcess RNA nucleotide deletion The modification of an RNA molecule by removal of a single nucleotide. go.json RNA nucleotide excision http://purl.obolibrary.org/obo/GO_0070706 GO:0070703 biolink:CellularComponent outer mucus layer The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria. go.json http://purl.obolibrary.org/obo/GO_0070703 GO:0045769 biolink:BiologicalProcess negative regulation of asymmetric cell division Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. go.json down regulation of asymmetric cell division|down-regulation of asymmetric cell division|downregulation of asymmetric cell division|inhibition of asymmetric cell division http://purl.obolibrary.org/obo/GO_0045769 GO:0070704 biolink:MolecularActivity sterol desaturase activity Catalysis of the introduction of a double bond into a sterol molecule. go.json http://purl.obolibrary.org/obo/GO_0070704 GO:0045767 biolink:BiologicalProcess obsolete regulation of anti-apoptosis OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis. go.json regulation of anti-apoptosis True http://purl.obolibrary.org/obo/GO_0045767 GO:0070701 biolink:CellularComponent mucus layer An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. go.json extracellular proteinaceous gel|mucous|mucous layer|mucus http://purl.obolibrary.org/obo/GO_0070701 GO:0070702 biolink:CellularComponent inner mucus layer The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria. go.json http://purl.obolibrary.org/obo/GO_0070702 GO:0045768 biolink:BiologicalProcess obsolete positive regulation of anti-apoptosis OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis. go.json activation of anti-apoptosis|positive regulation of anti-apoptosis|stimulation of anti-apoptosis|up regulation of anti-apoptosis|up-regulation of anti-apoptosis|upregulation of anti-apoptosis True http://purl.obolibrary.org/obo/GO_0045768 GO:0021776 biolink:BiologicalProcess smoothened signaling pathway involved in spinal cord motor neuron cell fate specification The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. go.json hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification|hh signaling pathway involved in spinal cord motor neuron cell fate specification|smoothened signalling pathway involved in spinal cord motor neuron cell fate specification http://purl.obolibrary.org/obo/GO_0021776 GO:0070700 biolink:MolecularActivity BMP receptor binding Binding to a BMP receptor. go.json bone morphogenetic protein receptor binding http://purl.obolibrary.org/obo/GO_0070700 GO:0021777 biolink:BiologicalProcess obsolete BMP signaling pathway involved in spinal cord association neuron specification OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate. go.json BMP signalling pathway involved in spinal cord association neuron specification|bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification True http://purl.obolibrary.org/obo/GO_0021777 GO:0021778 biolink:BiologicalProcess oligodendrocyte cell fate specification The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0021778 GO:0021779 biolink:BiologicalProcess oligodendrocyte cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte. go.json http://purl.obolibrary.org/obo/GO_0021779 GO:0006128 biolink:BiologicalProcess obsolete oxidized glutathione reduction OBSOLETE. (Was not defined before being made obsolete). go.json oxidized glutathione reduction True http://purl.obolibrary.org/obo/GO_0006128 GO:0021761 biolink:BiologicalProcess limbic system development The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. go.json http://purl.obolibrary.org/obo/GO_0021761 GO:0006129 biolink:BiologicalProcess obsolete protein-disulfide reduction OBSOLETE. (Was not defined before being made obsolete). go.json protein-disulfide reduction|protein-disulphide reduction True http://purl.obolibrary.org/obo/GO_0006129 GO:0021762 biolink:BiologicalProcess substantia nigra development The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). go.json http://purl.obolibrary.org/obo/GO_0021762 GO:0021763 biolink:BiologicalProcess subthalamic nucleus development The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function. go.json corpus luysi development http://purl.obolibrary.org/obo/GO_0021763 GO:0006126 biolink:BiologicalProcess obsolete other pathways of electron transport OBSOLETE. (Was not defined before being made obsolete). go.json other pathways of electron transport True http://purl.obolibrary.org/obo/GO_0006126 GO:0006127 biolink:BiologicalProcess glycerophosphate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle. MetaCyc:PWY-6118 go.json http://purl.obolibrary.org/obo/GO_0006127 GO:0021764 biolink:BiologicalProcess amygdala development The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. go.json http://purl.obolibrary.org/obo/GO_0021764 GO:0045776 biolink:BiologicalProcess negative regulation of blood pressure Any process in which the force of blood traveling through the circulatory system is decreased. go.json down regulation of blood pressure|down-regulation of blood pressure|downregulation of blood pressure|inhibition of blood pressure http://purl.obolibrary.org/obo/GO_0045776 GO:0006124 biolink:BiologicalProcess ferredoxin metabolic process The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each. go.json ferredoxin metabolism http://purl.obolibrary.org/obo/GO_0006124 GO:0045777 biolink:BiologicalProcess positive regulation of blood pressure Any process in which the force of blood traveling through the circulatory system is increased. go.json activation of blood pressure|stimulation of blood pressure|up regulation of blood pressure|up-regulation of blood pressure|upregulation of blood pressure http://purl.obolibrary.org/obo/GO_0045777 GO:0006125 biolink:BiologicalProcess obsolete thioredoxin pathway OBSOLETE. This term was not defined before being made obsolete. MetaCyc:THIOREDOX-PWY go.json thioredoxin pathway|thioredoxin reduction True http://purl.obolibrary.org/obo/GO_0006125 GO:0045774 biolink:BiologicalProcess negative regulation of beta 2 integrin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. go.json down regulation of beta 2 integrin biosynthetic process|down-regulation of beta 2 integrin biosynthetic process|downregulation of beta 2 integrin biosynthetic process|inhibition of beta 2 integrin biosynthetic process|negative regulation of beta 2 integrin anabolism|negative regulation of beta 2 integrin biosynthesis|negative regulation of beta 2 integrin formation|negative regulation of beta 2 integrin synthesis http://purl.obolibrary.org/obo/GO_0045774 GO:0006122 biolink:BiologicalProcess mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. go.json complex III (ubiquinone to cytochrome c) http://purl.obolibrary.org/obo/GO_0006122 GO:0045775 biolink:BiologicalProcess positive regulation of beta 2 integrin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. go.json activation of beta 2 integrin biosynthetic process|positive regulation of beta 2 integrin anabolism|positive regulation of beta 2 integrin biosynthesis|positive regulation of beta 2 integrin formation|positive regulation of beta 2 integrin synthesis|stimulation of beta 2 integrin biosynthetic process|up regulation of beta 2 integrin biosynthetic process|up-regulation of beta 2 integrin biosynthetic process|upregulation of beta 2 integrin biosynthetic process http://purl.obolibrary.org/obo/GO_0045775 GO:0006123 biolink:BiologicalProcess mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. go.json complex IV (reduction of O2) http://purl.obolibrary.org/obo/GO_0006123 GO:0045772 biolink:BiologicalProcess positive regulation of autophagosome size Any process that increases autophagosome size. go.json activation of autophagic vacuole size|positive regulation of autophagic vacuole size|stimulation of autophagic vacuole size|up regulation of autophagic vacuole size|up-regulation of autophagic vacuole size|upregulation of autophagic vacuole size http://purl.obolibrary.org/obo/GO_0045772 GO:0006120 biolink:BiologicalProcess mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. go.json complex I (NADH to ubiquinone)|oxidative phosphorylation, NADH to ubiquinone http://purl.obolibrary.org/obo/GO_0006120 GO:0045773 biolink:BiologicalProcess positive regulation of axon extension Any process that activates or increases the frequency, rate or extent of axon extension. go.json activation of axon extension|stimulation of axon extension|up regulation of axon extension|up-regulation of axon extension|upregulation of axon extension http://purl.obolibrary.org/obo/GO_0045773 GO:0006121 biolink:BiologicalProcess mitochondrial electron transport, succinate to ubiquinone The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II. go.json complex II (succinate to ubiquinone)|mitochondrial electron transport, succinate to coenzyme Q|oxidative phosphorylation, succinate to ubiquinone http://purl.obolibrary.org/obo/GO_0006121 GO:0045770 biolink:BiologicalProcess positive regulation of asymmetric cell division Any process that activates or increases the frequency, rate or extent of asymmetric cell division. go.json activation of asymmetric cell division|stimulation of asymmetric cell division|up regulation of asymmetric cell division|up-regulation of asymmetric cell division|upregulation of asymmetric cell division http://purl.obolibrary.org/obo/GO_0045770 GO:0045771 biolink:BiologicalProcess negative regulation of autophagosome size Any process that reduces autophagosome size. go.json down regulation of autophagic vacuole size|down-regulation of autophagic vacuole size|downregulation of autophagic vacuole size|inhibition of autophagic vacuole size|negative regulation of autophagic vacuole size http://purl.obolibrary.org/obo/GO_0045771 GO:0070738 biolink:MolecularActivity tubulin-glycine ligase activity Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin. go.json tubulin glycylase activity http://purl.obolibrary.org/obo/GO_0070738 GO:0070739 biolink:MolecularActivity protein-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. go.json protein glutamylase activity|protein-glutamate ligase activity http://purl.obolibrary.org/obo/GO_0070739 GO:0070736 biolink:MolecularActivity protein-glycine ligase activity, initiating Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein. go.json protein glycylase activity, initiating http://purl.obolibrary.org/obo/GO_0070736 GO:0070737 biolink:MolecularActivity protein-glycine ligase activity, elongating Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain. go.json protein glycylase activity, elongating http://purl.obolibrary.org/obo/GO_0070737 GO:0070734 biolink:BiologicalProcess histone H3-K27 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone. go.json histone H3 K27 methylation|histone H3K27me|histone lysine H3 K27 methylation http://purl.obolibrary.org/obo/GO_0070734 gocheck_do_not_annotate GO:0045778 biolink:BiologicalProcess positive regulation of ossification Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. go.json activation of ossification|positive regulation of bone biosynthesis|positive regulation of bone formation|stimulation of ossification|up regulation of ossification|up-regulation of ossification|upregulation of ossification http://purl.obolibrary.org/obo/GO_0045778 GO:0070735 biolink:MolecularActivity protein-glycine ligase activity Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate. RHEA:67180|Reactome:R-HSA-8867370 go.json protein glycylase activity http://purl.obolibrary.org/obo/GO_0070735 GO:0045779 biolink:BiologicalProcess negative regulation of bone resorption Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. go.json down regulation of bone resorption|down-regulation of bone resorption|downregulation of bone resorption|inhibition of bone resorption http://purl.obolibrary.org/obo/GO_0045779 GO:0021765 biolink:BiologicalProcess cingulate gyrus development The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum. go.json http://purl.obolibrary.org/obo/GO_0021765 GO:0070732 biolink:CellularComponent spindle envelope An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase. go.json http://purl.obolibrary.org/obo/GO_0070732 goslim_candida GO:0021766 biolink:BiologicalProcess hippocampus development The progression of the hippocampus over time from its initial formation until its mature state. go.json hippocampal formation development http://purl.obolibrary.org/obo/GO_0021766 GO:0070733 biolink:MolecularActivity AMPylase activity Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins. EC:2.7.7.108 go.json AMPylator|adenosine monophosphate-protein transferase activity|protein adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0070733 GO:0021767 biolink:BiologicalProcess mammillary body development The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei. go.json http://purl.obolibrary.org/obo/GO_0021767 GO:0070730 biolink:BiologicalProcess cAMP transport The directed movement of cyclic AMP (cAMP), into, out of or within a cell. go.json cyclic AMP transport http://purl.obolibrary.org/obo/GO_0070730 GO:0070731 biolink:BiologicalProcess cGMP transport The directed movement of cyclic GMP (cGMP), into, out of or within a cell. go.json cyclic GMP transport http://purl.obolibrary.org/obo/GO_0070731 GO:0021768 biolink:BiologicalProcess nucleus accumbens development The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia. go.json accumbens nucleus development|ventral striatum development http://purl.obolibrary.org/obo/GO_0021768 GO:0021769 biolink:BiologicalProcess orbitofrontal cortex development The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe. go.json http://purl.obolibrary.org/obo/GO_0021769 GO:0045780 biolink:BiologicalProcess positive regulation of bone resorption Any process that activates or increases the frequency, rate or extent of bone resorption. go.json activation of bone resorption|stimulation of bone resorption|up regulation of bone resorption|up-regulation of bone resorption|upregulation of bone resorption http://purl.obolibrary.org/obo/GO_0045780 GO:0055106 biolink:MolecularActivity ubiquitin-protein transferase regulator activity Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. go.json http://purl.obolibrary.org/obo/GO_0055106 GO:0006139 biolink:BiologicalProcess nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. go.json cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism|nucleobase, nucleoside and nucleotide metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolism http://purl.obolibrary.org/obo/GO_0006139 goslim_pir|goslim_plant GO:0021750 biolink:BiologicalProcess vestibular nucleus development The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021750 GO:0021751 biolink:BiologicalProcess salivary nucleus development The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021751 GO:0055107 biolink:BiologicalProcess Golgi to secretory granule transport The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. go.json http://purl.obolibrary.org/obo/GO_0055107 GO:0055108 biolink:BiologicalProcess Golgi to transport vesicle transport The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. go.json http://purl.obolibrary.org/obo/GO_0055108 GO:0006137 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006137 GO:0021752 biolink:BiologicalProcess inferior salivary nucleus development The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021752 GO:0021753 biolink:BiologicalProcess superior salivary nucleus development The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021753 GO:0055109 biolink:BiologicalProcess invagination involved in gastrulation with mouth forming second The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation. go.json http://purl.obolibrary.org/obo/GO_0055109 GO:0006138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006138 GO:0045787 biolink:BiologicalProcess positive regulation of cell cycle Any process that activates or increases the rate or extent of progression through the cell cycle. go.json activation of progression through cell cycle|positive regulation of cell cycle progression|positive regulation of progression through cell cycle|stimulation of progression through cell cycle|up regulation of progression through cell cycle|up-regulation of progression through cell cycle|upregulation of progression through cell cycle http://purl.obolibrary.org/obo/GO_0045787 GO:0006135 biolink:BiologicalProcess obsolete dihydropteridine reduction OBSOLETE. (Was not defined before being made obsolete). go.json dihydropteridine reduction True http://purl.obolibrary.org/obo/GO_0006135 GO:0045788 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045788 GO:0006136 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006136 GO:0006133 biolink:BiologicalProcess obsolete 5,10-methylenetetrahydrofolate oxidation OBSOLETE. This term was not defined before being made obsolete. go.json 5,10-methylenetetrahydrofolate oxidation True http://purl.obolibrary.org/obo/GO_0006133 GO:0045785 biolink:BiologicalProcess positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion. go.json activation of cell adhesion|stimulation of cell adhesion|up regulation of cell adhesion|up-regulation of cell adhesion|upregulation of cell adhesion http://purl.obolibrary.org/obo/GO_0045785 GO:0006134 biolink:BiologicalProcess obsolete dihydrobiopterin reduction OBSOLETE. (Was not defined before being made obsolete). go.json dihydrobiopterin reduction True http://purl.obolibrary.org/obo/GO_0006134 GO:0045786 biolink:BiologicalProcess negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. go.json down regulation of progression through cell cycle|down-regulation of progression through cell cycle|downregulation of progression through cell cycle|inhibition of progression through cell cycle|negative regulation of cell cycle progression|negative regulation of progression through cell cycle http://purl.obolibrary.org/obo/GO_0045786 GO:0045783 biolink:BiologicalProcess obsolete negative regulation of calcium in ER OBSOLETE. Any process that reduces the concentration of calcium in the ER. go.json negative regulation of calcium in ER True http://purl.obolibrary.org/obo/GO_0045783 GO:0006131 biolink:BiologicalProcess obsolete dihydrolipoamide reduction OBSOLETE. (Was not defined before being made obsolete). go.json dihydrolipoamide reduction True http://purl.obolibrary.org/obo/GO_0006131 GO:0045784 biolink:BiologicalProcess obsolete positive regulation of calcium in ER OBSOLETE. Any process that increases the concentration of calcium in the ER. go.json positive regulation of calcium in ER True http://purl.obolibrary.org/obo/GO_0045784 GO:0006132 biolink:BiologicalProcess obsolete dihydrolipoylprotein reduction OBSOLETE. (Was not defined before being made obsolete). go.json dihydrolipoylprotein reduction True http://purl.obolibrary.org/obo/GO_0006132 GO:0045781 biolink:BiologicalProcess negative regulation of cell budding Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding. go.json down regulation of cell budding|down-regulation of cell budding|downregulation of cell budding|inhibition of cell budding|negative regulation of budding http://purl.obolibrary.org/obo/GO_0045781 GO:0045782 biolink:BiologicalProcess positive regulation of cell budding Any process that activates or increases the frequency, rate or extent of cell budding. go.json activation of cell budding|positive regulation of budding|stimulation of cell budding|up regulation of cell budding|up-regulation of cell budding|upregulation of cell budding http://purl.obolibrary.org/obo/GO_0045782 GO:0006130 biolink:BiologicalProcess obsolete 6-phosphofructokinase reduction OBSOLETE. (Was not defined before being made obsolete). go.json 6-phosphofructokinase reduction True http://purl.obolibrary.org/obo/GO_0006130 GO:0070729 biolink:BiologicalProcess cyclic nucleotide transport The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0070729 GO:0070727 biolink:BiologicalProcess cellular macromolecule localization Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. go.json cellular macromolecule localisation http://purl.obolibrary.org/obo/GO_0070727 GO:0070728 biolink:MolecularActivity leucine binding Binding to 2-amino-4-methylpentanoic acid. go.json Leu binding http://purl.obolibrary.org/obo/GO_0070728 GO:0070725 biolink:CellularComponent Yb body A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell. go.json http://purl.obolibrary.org/obo/GO_0070725 GO:0070726 biolink:BiologicalProcess cell wall assembly The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells. go.json http://purl.obolibrary.org/obo/GO_0070726 GO:0070723 biolink:BiologicalProcess response to cholesterol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. go.json http://purl.obolibrary.org/obo/GO_0070723 GO:0045789 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045789 GO:0070724 biolink:CellularComponent BMP receptor complex A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits. go.json bone morphogenetic protein receptor complex http://purl.obolibrary.org/obo/GO_0070724 GO:0070721 biolink:CellularComponent ISGF3 complex A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein. go.json interferon-stimulated gene factor 3 transcription complex http://purl.obolibrary.org/obo/GO_0070721 GO:0021754 biolink:BiologicalProcess facial nucleus development The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021754 GO:0055102 biolink:MolecularActivity lipase inhibitor activity Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. go.json http://purl.obolibrary.org/obo/GO_0055102 GO:0070722 biolink:CellularComponent Tle3-Aes complex A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product. go.json Grg3b-Grg5 complex http://purl.obolibrary.org/obo/GO_0070722 GO:0055103 biolink:MolecularActivity ligase regulator activity Binds to and modulates the activity of a ligase. go.json http://purl.obolibrary.org/obo/GO_0055103 GO:0021755 biolink:BiologicalProcess eurydendroid cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts. go.json http://purl.obolibrary.org/obo/GO_0021755 GO:0021756 biolink:BiologicalProcess striatum development The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. go.json neostriatum development|striate nucleus development http://purl.obolibrary.org/obo/GO_0021756 GO:0055104 biolink:MolecularActivity ligase inhibitor activity Binds to and stops, prevents or reduces the activity of a ligase. go.json http://purl.obolibrary.org/obo/GO_0055104 GO:0070720 biolink:CellularComponent Grb2-SHP-2 complex A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway. go.json GRB2-SHP-2 complex, PDGF stimulated http://purl.obolibrary.org/obo/GO_0070720 GO:0055105 biolink:MolecularActivity ubiquitin-protein transferase inhibitor activity Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase. go.json http://purl.obolibrary.org/obo/GO_0055105 GO:0021757 biolink:BiologicalProcess caudate nucleus development The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain. go.json http://purl.obolibrary.org/obo/GO_0021757 GO:0021758 biolink:BiologicalProcess putamen development The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain. go.json http://purl.obolibrary.org/obo/GO_0021758 GO:0021759 biolink:BiologicalProcess globus pallidus development The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain. go.json pallidum development http://purl.obolibrary.org/obo/GO_0021759 GO:0055100 biolink:MolecularActivity adiponectin binding Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. go.json http://purl.obolibrary.org/obo/GO_0055100 GO:0055101 biolink:MolecularActivity obsolete glycerophospholipase inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. go.json glycerophospholipase inhibitor activity True http://purl.obolibrary.org/obo/GO_0055101 GO:0045790 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045790 GO:0045791 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045791 GO:0006108 biolink:BiologicalProcess malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. go.json malate metabolism http://purl.obolibrary.org/obo/GO_0006108 GO:0006109 biolink:BiologicalProcess regulation of carbohydrate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. go.json regulation of carbohydrate metabolism http://purl.obolibrary.org/obo/GO_0006109 GO:0006106 biolink:BiologicalProcess fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. go.json fumarate metabolism http://purl.obolibrary.org/obo/GO_0006106 GO:0055117 biolink:BiologicalProcess regulation of cardiac muscle contraction Any process that modulates the frequency, rate or extent of cardiac muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0055117 GO:0006107 biolink:BiologicalProcess oxaloacetate metabolic process The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. go.json oxaloacetate metabolism http://purl.obolibrary.org/obo/GO_0006107 GO:0055118 biolink:BiologicalProcess negative regulation of cardiac muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0055118 GO:0021740 biolink:BiologicalProcess principal sensory nucleus of trigeminal nerve development The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure. go.json pontine nucleus development http://purl.obolibrary.org/obo/GO_0021740 GO:0055119 biolink:BiologicalProcess relaxation of cardiac muscle The process in which the extent of cardiac muscle contraction is reduced. go.json http://purl.obolibrary.org/obo/GO_0055119 GO:0006104 biolink:BiologicalProcess succinyl-CoA metabolic process The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A. go.json succinyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0006104 GO:0021741 biolink:BiologicalProcess spinal trigeminal nucleus development The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021741 GO:0006105 biolink:BiologicalProcess succinate metabolic process The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle. go.json succinate metabolism http://purl.obolibrary.org/obo/GO_0006105 GO:0021742 biolink:BiologicalProcess abducens nucleus development The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021742 GO:0045798 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045798 GO:0006102 biolink:BiologicalProcess isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. go.json isocitrate metabolism http://purl.obolibrary.org/obo/GO_0006102 GO:0006103 biolink:BiologicalProcess 2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. go.json 2-ketoglutarate metabolic process|2-ketoglutarate metabolism|2-oxoglutarate metabolism|alpha-ketoglutarate metabolic process|alpha-ketoglutarate metabolism|alpha-oxoglutarate metabolic process|alpha-oxoglutarate metabolism http://purl.obolibrary.org/obo/GO_0006103 GO:0045799 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045799 GO:0006100 biolink:BiologicalProcess obsolete tricarboxylic acid cycle intermediate metabolic process OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle. go.json Krebs cycle intermediate metabolic process|Krebs cycle intermediate metabolism|TCA intermediate metabolic process|TCA intermediate metabolism|citric acid cycle intermediate metabolic process|citric acid cycle intermediate metabolism|tricarboxylic acid cycle intermediate metabolic process|tricarboxylic acid cycle intermediate metabolism True http://purl.obolibrary.org/obo/GO_0006100 GO:0045796 biolink:BiologicalProcess negative regulation of intestinal cholesterol absorption Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine. go.json down regulation of cholesterol absorption|down-regulation of cholesterol absorption|downregulation of cholesterol absorption|inhibition of cholesterol absorption http://purl.obolibrary.org/obo/GO_0045796 GO:0045797 biolink:BiologicalProcess positive regulation of intestinal cholesterol absorption Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine. go.json activation of cholesterol absorption|stimulation of cholesterol absorption|up regulation of cholesterol absorption|up-regulation of cholesterol absorption|upregulation of cholesterol absorption http://purl.obolibrary.org/obo/GO_0045797 GO:0006101 biolink:BiologicalProcess citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle. go.json citrate metabolism http://purl.obolibrary.org/obo/GO_0006101 GO:0045794 biolink:BiologicalProcess negative regulation of cell volume Any process that decreases cell volume. go.json RVD|cell regulatory volume decrease http://purl.obolibrary.org/obo/GO_0045794 GO:0045795 biolink:BiologicalProcess positive regulation of cell volume Any process that increases cell volume. go.json http://purl.obolibrary.org/obo/GO_0045795 GO:0045792 biolink:BiologicalProcess negative regulation of cell size Any process that reduces cell size. go.json down regulation of cell size|down-regulation of cell size|downregulation of cell size|inhibition of cell size http://purl.obolibrary.org/obo/GO_0045792 GO:0045793 biolink:BiologicalProcess positive regulation of cell size Any process that increases cell size. go.json activation of cell size|stimulation of cell size|up regulation of cell size|up-regulation of cell size|upregulation of cell size http://purl.obolibrary.org/obo/GO_0045793 GO:0070758 biolink:BiologicalProcess regulation of interleukin-35-mediated signaling pathway Any process that modulates the rate, frequency or extent of an interleukin-35-mediated signaling pathway. go.json regulation of IL-35-mediated signaling pathway|regulation of interleukin-35-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070758 GO:0070759 biolink:BiologicalProcess negative regulation of interleukin-35-mediated signaling pathway Any process that decreases the rate, frequency or extent of an interleukin-35-mediated signaling pathway. go.json negative regulation of IL-35-mediated signaling pathway|negative regulation of interleukin-35-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070759 GO:0070756 biolink:BiologicalProcess positive regulation of interleukin-35 production Any process that activates or increases the frequency, rate, or extent of interleukin-35 production. go.json activation of interleukin-35 production|positive regulation of IL-35 production|positive regulation of interleukin-35 biosynthetic process|stimulation of interleukin-35 production|up regulation of interleukin-35 production|up-regulation of interleukin-35 production|upregulation of interleukin-35 production http://purl.obolibrary.org/obo/GO_0070756 GO:0070757 biolink:BiologicalProcess interleukin-35-mediated signaling pathway The series of molecular signals initiated by interleukin-35 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-35-mediated signaling pathway|interleukin-35-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070757 GO:0070754 biolink:BiologicalProcess regulation of interleukin-35 production Any process that modulates the frequency, rate, or extent of interleukin-35 production. go.json regulation of IL-35 production|regulation of interleukin-35 biosynthetic process http://purl.obolibrary.org/obo/GO_0070754 GO:0055113 biolink:BiologicalProcess epiboly involved in gastrulation with mouth forming second The expansion of one cell sheet over other cells involved in deuterostomic gastrulation. go.json http://purl.obolibrary.org/obo/GO_0055113 GO:0021743 biolink:BiologicalProcess hypoglossal nucleus development The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021743 GO:0055114 biolink:BiologicalProcess obsolete oxidation-reduction process OBSOLETE. A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. go.json oxidation reduction|oxidoreductase process True http://purl.obolibrary.org/obo/GO_0055114 GO:0070755 biolink:BiologicalProcess negative regulation of interleukin-35 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production. go.json down regulation of interleukin-35 production|down-regulation of interleukin-35 production|downregulation of interleukin-35 production|inhibition of interleukin-35 production|negative regulation of IL-35 production|negative regulation of interleukin-35 biosynthetic process http://purl.obolibrary.org/obo/GO_0070755 GO:0021744 biolink:BiologicalProcess dorsal motor nucleus of vagus nerve development The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021744 GO:0021745 biolink:BiologicalProcess nucleus ambiguus development The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021745 GO:0055115 biolink:BiologicalProcess entry into diapause The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. Wikipedia:Diapause go.json http://purl.obolibrary.org/obo/GO_0055115 GO:0070752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070752 GO:0070753 biolink:BiologicalProcess interleukin-35 production The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-35 production|interleukin-35 biosynthetic process|interleukin-35 secretion http://purl.obolibrary.org/obo/GO_0070753 gocheck_do_not_annotate GO:0055116 biolink:BiologicalProcess entry into reproductive diapause The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. go.json http://purl.obolibrary.org/obo/GO_0055116 GO:0021746 biolink:BiologicalProcess solitary nucleus development The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021746 GO:0070750 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070750 GO:0021747 biolink:BiologicalProcess cochlear nucleus development The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021747 GO:0055110 biolink:BiologicalProcess involution involved in gastrulation with mouth forming second The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation. go.json http://purl.obolibrary.org/obo/GO_0055110 GO:0070751 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070751 GO:0021748 biolink:BiologicalProcess dorsal cochlear nucleus development The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021748 GO:0055111 biolink:BiologicalProcess ingression involved in gastrulation with mouth forming second The migration of individual cells into the embryo involved in deuterostomic gastrulation. go.json http://purl.obolibrary.org/obo/GO_0055111 GO:0021749 biolink:BiologicalProcess ventral cochlear nucleus development The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021749 GO:0055112 biolink:BiologicalProcess delamination involved in gastrulation with mouth forming second The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation. go.json http://purl.obolibrary.org/obo/GO_0055112 GO:0006119 biolink:BiologicalProcess oxidative phosphorylation The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. Wikipedia:Oxidative_phosphorylation go.json respiratory-chain phosphorylation http://purl.obolibrary.org/obo/GO_0006119 goslim_pir GO:0006117 biolink:BiologicalProcess acetaldehyde metabolic process The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. go.json acetaldehyde metabolism|ethanal metabolic process|ethanal metabolism http://purl.obolibrary.org/obo/GO_0006117 GO:0055128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055128 GO:0055129 biolink:BiologicalProcess L-proline biosynthetic process The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. go.json pyrrolidine-2-carboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0055129 GO:0006118 biolink:BiologicalProcess obsolete electron transport OBSOLETE. The transport of electrons from an electron donor to an electron acceptor. go.json 6-phosphofructokinase reduction|dihydrobiopterin reduction|dihydrolipoamide reduction|dihydrolipoylprotein reduction|dihydropteridine reduction|electron transfer|electron transport|other pathways of electron transport|oxidized glutathione reduction|protein-disulfide reduction True http://purl.obolibrary.org/obo/GO_0006118 GO:0006115 biolink:BiologicalProcess ethanol biosynthetic process The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. go.json ethanol anabolism|ethanol biosynthesis|ethanol formation|ethanol synthesis http://purl.obolibrary.org/obo/GO_0006115 GO:0021730 biolink:BiologicalProcess trigeminal sensory nucleus development The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021730 GO:0021731 biolink:BiologicalProcess trigeminal motor nucleus development The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021731 GO:0006116 biolink:BiologicalProcess NADH oxidation A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+. go.json NAD (reduced) dehydrogenation|NAD (reduced) oxidation|NADH dehydrogenation|reduced NAD dehydrogenation|reduced NAD oxidation|reduced nicotinamide adenine dinucleotide dehydrogenation|reduced nicotinamide adenine dinucleotide oxidation http://purl.obolibrary.org/obo/GO_0006116 GO:0006113 biolink:BiologicalProcess fermentation The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP). MetaCyc:FERMENTATION-PWY|Wikipedia:Fermentation_(biochemistry) go.json http://purl.obolibrary.org/obo/GO_0006113 goslim_pir GO:0006114 biolink:BiologicalProcess glycerol biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. go.json glycerol anabolism|glycerol biosynthesis|glycerol formation|glycerol synthesis http://purl.obolibrary.org/obo/GO_0006114 GO:0006111 biolink:BiologicalProcess regulation of gluconeogenesis Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. go.json regulation of gluconeogenesis involved in cellular glucose homeostasis|regulation of glucose biosynthesis|regulation of glucose biosynthetic process http://purl.obolibrary.org/obo/GO_0006111 GO:0006112 biolink:BiologicalProcess energy reserve metabolic process The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. go.json energy reserve metabolism http://purl.obolibrary.org/obo/GO_0006112 goslim_pir GO:0006110 biolink:BiologicalProcess regulation of glycolytic process Any process that modulates the frequency, rate or extent of glycolysis. go.json regulation of glycolysis involved in cellular glucose homeostasis http://purl.obolibrary.org/obo/GO_0006110 GO:0070749 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070749 GO:0070747 biolink:MolecularActivity interleukin-35 receptor activity Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-35 receptor activity|IL-35R http://purl.obolibrary.org/obo/GO_0070747 GO:0070748 biolink:MolecularActivity interleukin-35 receptor binding Binding to an interleukin-35 receptor. go.json IL-35|interleukin-35 receptor ligand http://purl.obolibrary.org/obo/GO_0070748 GO:0070745 biolink:CellularComponent interleukin-35 complex A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space. go.json EBI3|IL-35 complex|IL12A|p35 http://purl.obolibrary.org/obo/GO_0070745 GO:0070746 biolink:MolecularActivity interleukin-35 binding Binding to interleukin-35. go.json IL-35 binding http://purl.obolibrary.org/obo/GO_0070746 GO:0021732 biolink:BiologicalProcess midbrain-hindbrain boundary maturation A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. go.json MHB maturation|isthmus maturation http://purl.obolibrary.org/obo/GO_0021732 GO:0070743 biolink:CellularComponent interleukin-23 complex A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. go.json IL-23 complex|IL12B|IL23A|p19|p40 http://purl.obolibrary.org/obo/GO_0070743 GO:0055124 biolink:BiologicalProcess obsolete premature neural plate formation OBSOLETE. The formation of the neural plate before the appropriate time. go.json premature neural plate formation True http://purl.obolibrary.org/obo/GO_0055124 GO:0055125 biolink:CellularComponent obsolete Nic96 complex OBSOLETE. A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p. go.json Nic96 complex True http://purl.obolibrary.org/obo/GO_0055125 GO:0070744 biolink:CellularComponent interleukin-27 complex A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space. go.json EBI3|IL-27 complex|IL27|p28 http://purl.obolibrary.org/obo/GO_0070744 GO:0021733 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0021733 GO:0070741 biolink:BiologicalProcess response to interleukin-6 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. go.json response to IL-6 http://purl.obolibrary.org/obo/GO_0070741 GO:0055126 biolink:CellularComponent obsolete Nup82 complex OBSOLETE. A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p. go.json Nup82 complex True http://purl.obolibrary.org/obo/GO_0055126 GO:0021734 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0021734 GO:0055127 biolink:BiologicalProcess vibrational conductance of sound to the inner ear The transmission of vibrations via ossicles to the inner ear. go.json http://purl.obolibrary.org/obo/GO_0055127 GO:0070742 biolink:MolecularActivity C2H2 zinc finger domain binding Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. go.json http://purl.obolibrary.org/obo/GO_0070742 GO:0021735 biolink:BiologicalProcess dentate nucleus development The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021735 GO:0055120 biolink:CellularComponent striated muscle dense body A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere. go.json http://purl.obolibrary.org/obo/GO_0055120 GO:0021736 biolink:BiologicalProcess globose nucleus development The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021736 GO:0055121 biolink:BiologicalProcess response to high fluence blue light stimulus by blue high-fluence system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2. go.json response to high fluence blue light|response to high fluence blue light by bhf system http://purl.obolibrary.org/obo/GO_0055121 GO:0070740 biolink:MolecularActivity tubulin-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. EC:6.3.2.61|Reactome:R-HSA-8865774|Reactome:R-HSA-8955869 go.json tubulin glutamylase activity|tubulin-glutamate ligase activity http://purl.obolibrary.org/obo/GO_0070740 GO:0021737 biolink:BiologicalProcess emboliform nucleus development The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021737 GO:0021738 biolink:BiologicalProcess fastigial nucleus development The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021738 GO:0055122 biolink:BiologicalProcess response to very low light intensity stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec. go.json http://purl.obolibrary.org/obo/GO_0055122 GO:0021739 biolink:BiologicalProcess mesencephalic trigeminal nucleus development The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021739 GO:0055123 biolink:BiologicalProcess digestive system development The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0055123 GO:0021720 biolink:BiologicalProcess superior olivary nucleus formation The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. go.json http://purl.obolibrary.org/obo/GO_0021720 GO:0021729 biolink:BiologicalProcess superior reticular formation development The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021729 GO:0055130 biolink:BiologicalProcess D-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine. go.json (2R)-2-aminopropanoic acid catabolic process http://purl.obolibrary.org/obo/GO_0055130 GO:0070778 biolink:BiologicalProcess L-aspartate transmembrane transport The directed movement of L-aspartate across a membrane. go.json L-aspartate transport http://purl.obolibrary.org/obo/GO_0070778 GO:0070779 biolink:BiologicalProcess D-aspartate import across plasma membrane The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. go.json D-aspartate import|D-aspartate import into cell|D-aspartate uptake http://purl.obolibrary.org/obo/GO_0070779 GO:0070776 biolink:CellularComponent MOZ/MORF histone acetyltransferase complex A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. go.json http://purl.obolibrary.org/obo/GO_0070776 GO:0021721 biolink:BiologicalProcess superior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. go.json superior olivary nucleus structural organisation http://purl.obolibrary.org/obo/GO_0021721 GO:0070777 biolink:BiologicalProcess D-aspartate transport The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0070777 GO:0021722 biolink:BiologicalProcess superior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. go.json superior olive maturation http://purl.obolibrary.org/obo/GO_0021722 GO:0070774 biolink:MolecularActivity phytoceramidase activity Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine. KEGG_REACTION:R06528|MetaCyc:CERAMIDASE-YEAST-RXN|Reactome:R-HSA-428262 go.json http://purl.obolibrary.org/obo/GO_0070774 GO:0021723 biolink:BiologicalProcess medullary reticular formation development The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata. go.json rhombencephalic reticular formation development http://purl.obolibrary.org/obo/GO_0021723 GO:0070775 biolink:CellularComponent H3 histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histone H3. go.json H3 HAT complex http://purl.obolibrary.org/obo/GO_0070775 GO:0021724 biolink:BiologicalProcess inferior raphe nucleus development The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure. go.json inferior central nucleus development|posterior raphe nucleus development http://purl.obolibrary.org/obo/GO_0021724 GO:0055131 biolink:MolecularActivity C3HC4-type RING finger domain binding Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. go.json http://purl.obolibrary.org/obo/GO_0055131 GO:0070772 biolink:CellularComponent PAS complex A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p. go.json autophagy-specific phosphatidylinositol 3-kinase complex http://purl.obolibrary.org/obo/GO_0070772 GO:0021725 biolink:BiologicalProcess superior raphe nucleus development The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure. go.json anterior raphe nucleus development|superior central nucleus development http://purl.obolibrary.org/obo/GO_0021725 GO:0021726 biolink:BiologicalProcess lateral reticular nucleus development The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021726 GO:0070773 biolink:MolecularActivity protein-N-terminal glutamine amidohydrolase activity Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein. EC:3.5.1.122|RHEA:50680 go.json NtQ-amidase activity http://purl.obolibrary.org/obo/GO_0070773 GO:0055132 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055132 GO:0021727 biolink:BiologicalProcess intermediate reticular formation development The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure. go.json intermediate reticular nucleus development http://purl.obolibrary.org/obo/GO_0021727 GO:0055133 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055133 GO:0070770 biolink:CellularComponent alphaIIb-beta3 integrin-CD47-FAK complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK. go.json ITGA2b-ITGB3-CD47-FAK complex http://purl.obolibrary.org/obo/GO_0070770 GO:0021728 biolink:BiologicalProcess inferior reticular formation development The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021728 GO:0070771 biolink:CellularComponent alphaIIb-beta3 integrin-CD47-Src complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src. go.json ITGA2b-ITGB3-CD47-SRC complex http://purl.obolibrary.org/obo/GO_0070771 GO:0055134 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055134 GO:0021718 biolink:BiologicalProcess superior olivary nucleus development The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. go.json superior olive development http://purl.obolibrary.org/obo/GO_0021718 GO:0021719 biolink:BiologicalProcess superior olivary nucleus morphogenesis The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. go.json superior olive morphogenesis http://purl.obolibrary.org/obo/GO_0021719 GO:0070769 biolink:CellularComponent alphaIIb-beta3 integrin-CIB complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin. go.json ITGA2B-ITGB3-CIB1 complex http://purl.obolibrary.org/obo/GO_0070769 GO:0070767 biolink:CellularComponent BRCA1-Rad51 complex A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity. go.json http://purl.obolibrary.org/obo/GO_0070767 GO:0070768 biolink:CellularComponent synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof). go.json SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)|Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex http://purl.obolibrary.org/obo/GO_0070768 GO:0070765 biolink:CellularComponent gamma-secretase complex A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. go.json CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)|PS1 complex|PS2 complex|gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)|gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)|gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)|gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)|presenilin complex http://purl.obolibrary.org/obo/GO_0070765 GO:0021710 biolink:BiologicalProcess cerebellar stellate cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021710 GO:0070766 biolink:CellularComponent endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof). go.json SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)|Stx4-Napa-Vamp3-Nsf-Vamp2 complex http://purl.obolibrary.org/obo/GO_0070766 GO:0021711 biolink:BiologicalProcess cerebellar unipolar brush cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021711 GO:0021712 biolink:BiologicalProcess candelabrum cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021712 GO:0070763 biolink:CellularComponent Delta1 complex A protein complex that consists of homodimer of the Notch ligand Delta1. go.json Delta1 homodimer complex http://purl.obolibrary.org/obo/GO_0070763 GO:0070764 biolink:CellularComponent gamma-secretase-Delta1 complex A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex. go.json http://purl.obolibrary.org/obo/GO_0070764 GO:0021713 biolink:BiologicalProcess inferior olivary nucleus development The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. go.json inferior olive development http://purl.obolibrary.org/obo/GO_0021713 GO:0070761 biolink:CellularComponent pre-snoRNP complex A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. go.json pre-small nucleolar ribonucleoprotein complex http://purl.obolibrary.org/obo/GO_0070761 GO:0021714 biolink:BiologicalProcess inferior olivary nucleus morphogenesis The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. go.json inferior olive morphogenesis http://purl.obolibrary.org/obo/GO_0021714 GO:0070762 biolink:CellularComponent nuclear pore transmembrane ring A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex. go.json NDC1 complex|NDC1 subcomplex http://purl.obolibrary.org/obo/GO_0070762 GO:0021715 biolink:BiologicalProcess inferior olivary nucleus formation The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. go.json inferior olive biosynthesis|inferior olive formation http://purl.obolibrary.org/obo/GO_0021715 GO:0021716 biolink:BiologicalProcess inferior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. go.json inferior olivary nucleus structural organisation|inferior olive structural organization http://purl.obolibrary.org/obo/GO_0021716 GO:0070760 biolink:BiologicalProcess positive regulation of interleukin-35-mediated signaling pathway Any process that increases the rate, frequency or extent of an interleukin-35-mediated signaling pathway. go.json positive regulation of IL-35-mediated signaling pathway|positive regulation of interleukin-35-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070760 GO:0021717 biolink:BiologicalProcess inferior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. go.json inferior olive maturation http://purl.obolibrary.org/obo/GO_0021717 GO:0031182 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031182 GO:0031183 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031183 GO:0031180 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031180 GO:0031181 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031181 GO:0031188 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031188 GO:0031189 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031189 GO:0031186 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031186 GO:0031187 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031187 GO:0031184 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031184 GO:0031185 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031185 GO:0031171 biolink:BiologicalProcess ferricrocin biosynthetic process The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. go.json ferricrocin anabolism|ferricrocin biosynthesis|ferricrocin biosynthetic process, peptide formation|ferricrocin biosynthetic process, peptide modification|ferricrocin formation|ferricrocin synthesis http://purl.obolibrary.org/obo/GO_0031171 GO:0031172 biolink:MolecularActivity ornithine N5-monooxygenase activity Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O. MetaCyc:RXN-11128|RHEA:41508 go.json L-ornithine 5-monooxygenase activity http://purl.obolibrary.org/obo/GO_0031172 GO:0031170 biolink:BiologicalProcess ferricrocin metabolic process The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. go.json ferricrocin metabolism http://purl.obolibrary.org/obo/GO_0031170 GO:0031179 biolink:BiologicalProcess peptide modification The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide. go.json http://purl.obolibrary.org/obo/GO_0031179 GO:0031177 biolink:MolecularActivity phosphopantetheine binding Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). go.json http://purl.obolibrary.org/obo/GO_0031177 GO:0031178 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031178 GO:0031175 biolink:BiologicalProcess neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). go.json neurite biosynthesis|neurite development|neurite formation|neurite growth|neurite outgrowth http://purl.obolibrary.org/obo/GO_0031175 GO:0031176 biolink:MolecularActivity endo-1,4-beta-xylanase activity Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. EC:3.2.1.8|MetaCyc:3.2.1.8-RXN go.json 1,4-beta-D-xylan xylanohydrolase activity|1,4-beta-xylan xylanohydrolase activity|beta-1,4-xylan xylanohydrolase activity|beta-1,4-xylanase activity|beta-D-xylanase activity|beta-xylanase activity|endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity|endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity|endo-1,4-beta-D-xylanase activity|endo-1,4-xylanase activity|endo-beta-1,4-xylanase activity|xylanase http://purl.obolibrary.org/obo/GO_0031176 GO:0031173 biolink:BiologicalProcess otolith mineralization completed early in development The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear. go.json otoconia mineralization|otoconium mineralization http://purl.obolibrary.org/obo/GO_0031173 GO:0031174 biolink:BiologicalProcess lifelong otolith mineralization The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added. go.json http://purl.obolibrary.org/obo/GO_0031174 GO:0031160 biolink:CellularComponent spore wall The specialized envelope lying outside the cell membrane of a spore. go.json spore coat http://purl.obolibrary.org/obo/GO_0031160 GO:0031161 biolink:BiologicalProcess phosphatidylinositol catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. go.json PtdIns catabolic process|PtdIns catabolism|phosphatidylinositol breakdown|phosphatidylinositol catabolism|phosphatidylinositol degradation http://purl.obolibrary.org/obo/GO_0031161 GO:0031168 biolink:BiologicalProcess ferrichrome metabolic process The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. go.json ferrichrome metabolism http://purl.obolibrary.org/obo/GO_0031168 GO:0031169 biolink:BiologicalProcess ferrichrome biosynthetic process The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. go.json ferrichrome anabolism|ferrichrome biosynthesis|ferrichrome biosynthetic process, peptide formation|ferrichrome biosynthetic process, peptide modification|ferrichrome formation|ferrichrome synthesis http://purl.obolibrary.org/obo/GO_0031169 GO:0031166 biolink:CellularComponent obsolete integral component of vacuolar membrane OBSOLETE. The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. go.json integral to vacuolar membrane True http://purl.obolibrary.org/obo/GO_0031166 GO:0031167 biolink:BiologicalProcess rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0031167 GO:0031164 biolink:CellularComponent contractile vacuolar membrane The lipid bilayer surrounding the contractile vacuole. go.json contractile vacuole membrane http://purl.obolibrary.org/obo/GO_0031164 GO:0031165 biolink:CellularComponent obsolete integral component of contractile vacuolar membrane OBSOLETE. The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer. go.json integral to contractile vacuolar membrane True http://purl.obolibrary.org/obo/GO_0031165 GO:0031162 biolink:BiologicalProcess sulfur incorporation into metallo-sulfur cluster The incorporation of exogenous sulfur into a metallo-sulfur cluster. go.json sulphur incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0031162 gocheck_do_not_annotate GO:0031163 biolink:BiologicalProcess metallo-sulfur cluster assembly The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. go.json metal-sulfur cluster assembly|metallo-sulfur cluster biosynthesis|metallo-sulphur cluster assembly http://purl.obolibrary.org/obo/GO_0031163 GO:0031159 biolink:BiologicalProcess positive regulation of aggregate size involved in sorocarp development Any process that increases the size of the aggregate formed during sorocarp formation. go.json activation of aggregate size|stimulation of aggregate size|up regulation of aggregate size|up-regulation of aggregate size|upregulation of aggregate size http://purl.obolibrary.org/obo/GO_0031159 GO:0045700 biolink:BiologicalProcess regulation of spermatid nuclear differentiation Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation. go.json http://purl.obolibrary.org/obo/GO_0045700 GO:0045707 biolink:BiologicalProcess regulation of adult salivary gland boundary specification Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism. go.json regulation of adult salivary gland determination http://purl.obolibrary.org/obo/GO_0045707 GO:0045708 biolink:BiologicalProcess regulation of larval salivary gland boundary specification Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism. go.json regulation of larval salivary gland determination http://purl.obolibrary.org/obo/GO_0045708 GO:0031150 biolink:BiologicalProcess sorocarp stalk development The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum. go.json sorophore development|stalk development|stalk formation http://purl.obolibrary.org/obo/GO_0031150 GO:0045705 biolink:BiologicalProcess negative regulation of salivary gland boundary specification Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination. go.json down regulation of salivary gland determination|down-regulation of salivary gland determination|downregulation of salivary gland determination|inhibition of salivary gland determination|negative regulation of salivary gland determination http://purl.obolibrary.org/obo/GO_0045705 GO:0045706 biolink:BiologicalProcess positive regulation of salivary gland boundary specification Any process that activates or increases the frequency, rate or extent of salivary gland determination. go.json activation of salivary gland determination|positive regulation of salivary gland determination|stimulation of salivary gland determination|up regulation of salivary gland determination|up-regulation of salivary gland determination|upregulation of salivary gland determination http://purl.obolibrary.org/obo/GO_0045706 GO:0045703 biolink:MolecularActivity ketoreductase activity Catalysis of the reduction of a ketone group to form the corresponding alcohol. go.json http://purl.obolibrary.org/obo/GO_0045703 GO:0045704 biolink:BiologicalProcess regulation of salivary gland boundary specification Any process that modulates the frequency, rate or extent of salivary gland determination. go.json regulation of salivary gland determination http://purl.obolibrary.org/obo/GO_0045704 GO:0045701 biolink:BiologicalProcess negative regulation of spermatid nuclear differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation. go.json down regulation of spermatid nuclear differentiation|down-regulation of spermatid nuclear differentiation|downregulation of spermatid nuclear differentiation|inhibition of spermatid nuclear differentiation http://purl.obolibrary.org/obo/GO_0045701 GO:0045702 biolink:BiologicalProcess positive regulation of spermatid nuclear differentiation Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation. go.json activation of spermatid nuclear differentiation|stimulation of spermatid nuclear differentiation|up regulation of spermatid nuclear differentiation|up-regulation of spermatid nuclear differentiation|upregulation of spermatid nuclear differentiation http://purl.obolibrary.org/obo/GO_0045702 GO:0031157 biolink:BiologicalProcess regulation of aggregate size involved in sorocarp development Any process that modulates the size of the aggregate formed during sorocarp formation. go.json regulation of aggregation during fruiting body biosynthesis|regulation of aggregation during fruiting body formation http://purl.obolibrary.org/obo/GO_0031157 GO:0031158 biolink:BiologicalProcess negative regulation of aggregate size involved in sorocarp development Any process that decreases the size of the aggregate formed during sorocarp formation. go.json down regulation of aggregate size|down-regulation of aggregate size|downregulation of aggregate size|inhibition of aggregate size http://purl.obolibrary.org/obo/GO_0031158 GO:0031155 biolink:BiologicalProcess regulation of reproductive fruiting body development Any process that modulates the frequency, rate or extent of reproductive fruiting body development. go.json regulation of fruiting body formation http://purl.obolibrary.org/obo/GO_0031155 GO:0031156 biolink:BiologicalProcess regulation of sorocarp development Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum. go.json regulation of fruiting body development|regulation of fruiting body formation http://purl.obolibrary.org/obo/GO_0031156 GO:0031153 biolink:BiologicalProcess slug development involved in sorocarp development The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development. go.json migratory slug development during sorocarp development|pseudoplasmodium biosynthesis|pseudoplasmodium formation|slug development during fruiting body development|slug development during sorocarp development|standing slug development during sorocarp development http://purl.obolibrary.org/obo/GO_0031153 GO:0031154 biolink:BiologicalProcess culmination involved in sorocarp development The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development. go.json culminant development|culmination during fruiting body development|culmination during sorocarp development http://purl.obolibrary.org/obo/GO_0031154 GO:0031151 biolink:MolecularActivity histone H3K79 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein. go.json histone H3K79 methylase activity|histone lysine N-methyltransferase activity (H3-K79 specific)|histone methylase activity (H3-K79 specific)|histone methyltransferase activity (H3-K79 specific)|histone-H3K79 methyltransferase activity http://purl.obolibrary.org/obo/GO_0031151 GO:0045709 biolink:BiologicalProcess negative regulation of adult salivary gland boundary specification Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism. go.json down regulation of adult salivary gland determination|down-regulation of adult salivary gland determination|downregulation of adult salivary gland determination|inhibition of adult salivary gland determination|negative regulation of adult salivary gland determination http://purl.obolibrary.org/obo/GO_0045709 GO:0031152 biolink:BiologicalProcess aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. go.json aggregate development involved in sorocarp development|aggregation during fruiting body development http://purl.obolibrary.org/obo/GO_0031152 GO:0031148 biolink:BiologicalProcess DIF-1 biosynthetic process The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. go.json 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism|1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis|1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process|1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation|1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis|DIF-1 biosynthesis http://purl.obolibrary.org/obo/GO_0031148 GO:0031149 biolink:BiologicalProcess sorocarp stalk cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum. go.json stalk cell differentiation http://purl.obolibrary.org/obo/GO_0031149 GO:0045710 biolink:BiologicalProcess negative regulation of larval salivary gland boundary specification Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism. go.json down regulation of larval salivary gland determination|down-regulation of larval salivary gland determination|downregulation of larval salivary gland determination|inhibition of larval salivary gland determination|negative regulation of larval salivary gland determination http://purl.obolibrary.org/obo/GO_0045710 GO:0045711 biolink:BiologicalProcess positive regulation of adult salivary gland boundary specification Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism. go.json activation of adult salivary gland determination|positive regulation of adult salivary gland determination|stimulation of adult salivary gland determination|up regulation of adult salivary gland determination|up-regulation of adult salivary gland determination|upregulation of adult salivary gland determination http://purl.obolibrary.org/obo/GO_0045711 GO:0006188 biolink:BiologicalProcess IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. go.json IMP anabolism|IMP biosynthesis|IMP formation|IMP synthesis http://purl.obolibrary.org/obo/GO_0006188 GO:0006189 biolink:BiologicalProcess 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. go.json 'de novo' IMP anabolism|'de novo' IMP biosynthesis|'de novo' IMP formation|'de novo' IMP synthesis|'de novo' purine biosynthesis|'de novo' purine biosynthetic process http://purl.obolibrary.org/obo/GO_0006189 GO:0006186 biolink:BiologicalProcess obsolete dGDP phosphorylation OBSOLETE. The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP. go.json True http://purl.obolibrary.org/obo/GO_0006186 GO:0006187 biolink:BiologicalProcess dGTP biosynthetic process from dGDP The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate. go.json dGTP anabolism from dGDP|dGTP formation from dGDP|dGTP synthesis from dGDP http://purl.obolibrary.org/obo/GO_0006187 GO:0006184 biolink:BiologicalProcess obsolete GTP catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate. go.json GTP breakdown|GTP catabolism|GTP degradation|GTP hydrolysis True http://purl.obolibrary.org/obo/GO_0006184 GO:0006185 biolink:BiologicalProcess dGDP biosynthetic process The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). go.json dGDP anabolism|dGDP biosynthesis|dGDP formation|dGDP synthesis http://purl.obolibrary.org/obo/GO_0006185 GO:0006193 biolink:BiologicalProcess ITP catabolic process The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate. go.json ITP breakdown|ITP catabolism|ITP degradation|ITP hydrolysis http://purl.obolibrary.org/obo/GO_0006193 GO:0045718 biolink:BiologicalProcess obsolete negative regulation of flagellum assembly OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum. go.json down regulation of flagellum assembly|down-regulation of flagellum assembly|downregulation of flagellum assembly|inhibition of flagellum assembly|negative regulation of flagella assembly|negative regulation of flagellum assembly|negative regulation of flagellum biogenesis True http://purl.obolibrary.org/obo/GO_0045718 GO:0045719 biolink:BiologicalProcess negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. go.json down regulation of glycogen biosynthetic process|down-regulation of glycogen biosynthetic process|downregulation of glycogen biosynthetic process|inhibition of glycogen biosynthetic process|negative regulation of glycogen anabolism|negative regulation of glycogen biosynthesis|negative regulation of glycogen formation|negative regulation of glycogen synthesis http://purl.obolibrary.org/obo/GO_0045719 GO:0006194 biolink:BiologicalProcess obsolete dIDP phosphorylation OBSOLETE. The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP. go.json True http://purl.obolibrary.org/obo/GO_0006194 GO:0006191 biolink:BiologicalProcess deoxyinosine salvage Any process that generates deoxyinosine from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0006191 GO:0045716 biolink:BiologicalProcess obsolete positive regulation of low-density lipoprotein particle receptor biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors. go.json activation of low-density lipoprotein receptor biosynthetic process|positive regulation of low-density lipoprotein receptor anabolism|positive regulation of low-density lipoprotein receptor biosynthesis|positive regulation of low-density lipoprotein receptor biosynthetic process|positive regulation of low-density lipoprotein receptor formation|positive regulation of low-density lipoprotein receptor synthesis|stimulation of low-density lipoprotein receptor biosynthetic process|up regulation of low-density lipoprotein receptor biosynthetic process|up-regulation of low-density lipoprotein receptor biosynthetic process|upregulation of low-density lipoprotein receptor biosynthetic process True http://purl.obolibrary.org/obo/GO_0045716 GO:0006192 biolink:BiologicalProcess obsolete IDP phosphorylation OBSOLETE. The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP. go.json True http://purl.obolibrary.org/obo/GO_0006192 GO:0045717 biolink:BiologicalProcess negative regulation of fatty acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. go.json down regulation of fatty acid biosynthetic process|down-regulation of fatty acid biosynthetic process|downregulation of fatty acid biosynthetic process|inhibition of fatty acid biosynthetic process|negative regulation of fatty acid anabolism|negative regulation of fatty acid biosynthesis|negative regulation of fatty acid formation|negative regulation of fatty acid synthesis http://purl.obolibrary.org/obo/GO_0045717 GO:0045714 biolink:BiologicalProcess obsolete regulation of low-density lipoprotein particle receptor biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors. go.json regulation of LDLr biosynthesis|regulation of LDLr biosynthetic process|regulation of low-density lipoprotein receptor anabolism|regulation of low-density lipoprotein receptor biosynthesis|regulation of low-density lipoprotein receptor biosynthetic process|regulation of low-density lipoprotein receptor formation|regulation of low-density lipoprotein receptor synthesis True http://purl.obolibrary.org/obo/GO_0045714 GO:0045715 biolink:BiologicalProcess obsolete negative regulation of low-density lipoprotein particle receptor biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors. go.json down regulation of low-density lipoprotein receptor biosynthetic process|down-regulation of low-density lipoprotein receptor biosynthetic process|downregulation of low-density lipoprotein receptor biosynthetic process|inhibition of low-density lipoprotein receptor biosynthetic process|negative regulation of low-density lipoprotein receptor anabolism|negative regulation of low-density lipoprotein receptor biosynthesis|negative regulation of low-density lipoprotein receptor biosynthetic process|negative regulation of low-density lipoprotein receptor formation|negative regulation of low-density lipoprotein receptor synthesis True http://purl.obolibrary.org/obo/GO_0045715 GO:0006190 biolink:BiologicalProcess inosine salvage Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis. go.json adenine, hypoxanthine and their nucleoside salvage|guanine, xanthine and their nucleoside salvage http://purl.obolibrary.org/obo/GO_0006190 GO:0045712 biolink:BiologicalProcess positive regulation of larval salivary gland boundary specification Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism. go.json activation of larval salivary gland determination|positive regulation of larval salivary gland determination|stimulation of larval salivary gland determination|up regulation of larval salivary gland determination|up-regulation of larval salivary gland determination|upregulation of larval salivary gland determination http://purl.obolibrary.org/obo/GO_0045712 GO:0045713 biolink:BiologicalProcess obsolete low-density lipoprotein particle receptor biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells. go.json LDLr biosynthesis|LDLr biosynthetic process|low-density lipoprotein receptor anabolism|low-density lipoprotein receptor biosynthesis|low-density lipoprotein receptor biosynthetic process|low-density lipoprotein receptor formation|low-density lipoprotein receptor synthesis True http://purl.obolibrary.org/obo/GO_0045713 GO:0031146 biolink:BiologicalProcess SCF-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. go.json SCF-dependent proteasomal ubiquitin-dependent protein breakdown|SCF-dependent proteasomal ubiquitin-dependent protein catabolism|SCF-dependent proteasomal ubiquitin-dependent protein degradation http://purl.obolibrary.org/obo/GO_0031146 GO:0031147 biolink:BiologicalProcess 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. go.json 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism|DIF-1 metabolic process|DIF-1 metabolism http://purl.obolibrary.org/obo/GO_0031147 GO:0031144 biolink:BiologicalProcess proteasome localization Any process in which the proteasome is transported to, or maintained in, a specific location. go.json establishment and maintenance of proteasome localization|proteasome localisation http://purl.obolibrary.org/obo/GO_0031144 GO:0031145 biolink:BiologicalProcess anaphase-promoting complex-dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. go.json APC-dependent proteasomal ubiquitin-dependent protein catabolic process|APC-dependent proteasomal ubiquitin-dependent protein catabolism|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation|cyclin breakdown|cyclin catabolic process|cyclin catabolism|cyclin degradation|degradation of cyclin|negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation http://purl.obolibrary.org/obo/GO_0031145 GO:0031142 biolink:BiologicalProcess induction of conjugation upon nitrogen starvation The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation. go.json http://purl.obolibrary.org/obo/GO_0031142 GO:0031143 biolink:CellularComponent pseudopodium A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. Wikipedia:Pseudopod go.json axopodium|lobopodium|pseudopod|pseudopodial protrusion|reticulopodium http://purl.obolibrary.org/obo/GO_0031143 goslim_pir GO:0031140 biolink:BiologicalProcess induction of conjugation upon nutrient starvation The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients. go.json http://purl.obolibrary.org/obo/GO_0031140 GO:0031141 biolink:BiologicalProcess induction of conjugation upon carbon starvation The process in which a cell initiates conjugation with cellular fusion upon carbon starvation. go.json http://purl.obolibrary.org/obo/GO_0031141 GO:0031139 biolink:BiologicalProcess positive regulation of conjugation with cellular fusion Any process that increases the rate or frequency of conjugation with cellular fusion. go.json activation of conjugation with cellular fusion|stimulation of conjugation with cellular fusion|up regulation of conjugation with cellular fusion|up-regulation of conjugation with cellular fusion|upregulation of conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0031139 GO:0031137 biolink:BiologicalProcess regulation of conjugation with cellular fusion Any process that modulates the rate or frequency of conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0031137 GO:0031138 biolink:BiologicalProcess negative regulation of conjugation with cellular fusion Any process that decreases the rate or frequency of conjugation with cellular fusion. go.json down regulation of conjugation with cellular fusion|down-regulation of conjugation with cellular fusion|downregulation of conjugation with cellular fusion|inhibition of conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0031138 GO:0045721 biolink:BiologicalProcess negative regulation of gluconeogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. go.json down regulation of gluconeogenesis|down-regulation of gluconeogenesis|downregulation of gluconeogenesis|inhibition of gluconeogenesis http://purl.obolibrary.org/obo/GO_0045721 GO:0045722 biolink:BiologicalProcess positive regulation of gluconeogenesis Any process that activates or increases the frequency, rate or extent of gluconeogenesis. go.json activation of gluconeogenesis|stimulation of gluconeogenesis|up regulation of gluconeogenesis|up-regulation of gluconeogenesis|upregulation of gluconeogenesis http://purl.obolibrary.org/obo/GO_0045722 GO:0006199 biolink:BiologicalProcess obsolete ADP reduction OBSOLETE. (Was not defined before being made obsolete). go.json ADP reduction True http://purl.obolibrary.org/obo/GO_0006199 GO:0045720 biolink:BiologicalProcess negative regulation of integrin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. go.json down regulation of integrin biosynthetic process|down-regulation of integrin biosynthetic process|downregulation of integrin biosynthetic process|inhibition of integrin biosynthetic process|negative regulation of integrin anabolism|negative regulation of integrin biosynthesis|negative regulation of integrin formation|negative regulation of integrin synthesis http://purl.obolibrary.org/obo/GO_0045720 GO:0006197 biolink:BiologicalProcess obsolete adenylate deaminase reaction OBSOLETE. (Was not defined before being made obsolete). go.json adenylate deaminase reaction True http://purl.obolibrary.org/obo/GO_0006197 GO:0006198 biolink:BiologicalProcess cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json 3',5' cAMP catabolic process|3',5' cAMP catabolism|3',5'-cAMP catabolic process|3',5'-cAMP catabolism|adenosine 3',5'-cyclophosphate catabolic process|adenosine 3',5'-cyclophosphate catabolism|cAMP breakdown|cAMP catabolism|cAMP degradation|cyclic AMP catabolic process|cyclic AMP catabolism http://purl.obolibrary.org/obo/GO_0006198 GO:0006195 biolink:BiologicalProcess purine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine nucleotide breakdown|purine nucleotide catabolism|purine nucleotide degradation http://purl.obolibrary.org/obo/GO_0006195 GO:0006196 biolink:BiologicalProcess AMP catabolic process The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. go.json AMP breakdown|AMP catabolism|AMP degradation http://purl.obolibrary.org/obo/GO_0006196 GO:0045729 biolink:BiologicalProcess respiratory burst at fertilization The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes. go.json metabolic burst at fertilization|oxidative burst at fertilization http://purl.obolibrary.org/obo/GO_0045729 GO:0045727 biolink:BiologicalProcess positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. go.json activation of protein biosynthetic process|positive regulation of protein anabolism|positive regulation of protein biosynthesis|positive regulation of protein biosynthetic process|positive regulation of protein formation|positive regulation of protein synthesis|stimulation of protein biosynthetic process|up regulation of protein biosynthetic process|up-regulation of protein biosynthetic process|upregulation of protein biosynthetic process http://purl.obolibrary.org/obo/GO_0045727 GO:0045728 biolink:BiologicalProcess respiratory burst after phagocytosis A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity. go.json metabolic burst after phagocytosis|oxidative burst after phagocytosis http://purl.obolibrary.org/obo/GO_0045728 GO:0045725 biolink:BiologicalProcess positive regulation of glycogen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. go.json activation of glycogen biosynthetic process|positive regulation of glycogen anabolism|positive regulation of glycogen biosynthesis|positive regulation of glycogen formation|positive regulation of glycogen synthesis|stimulation of glycogen biosynthetic process|up regulation of glycogen biosynthetic process|up-regulation of glycogen biosynthetic process|upregulation of glycogen biosynthetic process http://purl.obolibrary.org/obo/GO_0045725 GO:0045726 biolink:BiologicalProcess positive regulation of integrin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. go.json activation of integrin biosynthetic process|positive regulation of integrin anabolism|positive regulation of integrin biosynthesis|positive regulation of integrin formation|positive regulation of integrin synthesis|stimulation of integrin biosynthetic process|up regulation of integrin biosynthetic process|up-regulation of integrin biosynthetic process|upregulation of integrin biosynthetic process http://purl.obolibrary.org/obo/GO_0045726 GO:0045723 biolink:BiologicalProcess positive regulation of fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. go.json activation of fatty acid biosynthetic process|positive regulation of fatty acid anabolism|positive regulation of fatty acid biosynthesis|positive regulation of fatty acid formation|positive regulation of fatty acid synthesis|stimulation of fatty acid biosynthetic process|up regulation of fatty acid biosynthetic process|up-regulation of fatty acid biosynthetic process|upregulation of fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0045723 GO:0045724 biolink:BiologicalProcess positive regulation of cilium assembly Any process that activates or increases the frequency, rate or extent of the formation of a cilium. go.json activation of cilium assembly|positive regulation of flagellum assembly|positive regulation of flagellum biogenesis|stimulation of cilium assembly|up regulation of cilium assembly|up-regulation of cilium assembly|upregulation of cilium assembly http://purl.obolibrary.org/obo/GO_0045724 GO:0031135 biolink:BiologicalProcess obsolete negative regulation of conjugation OBSOLETE. Any process that decreases the rate of conjugation. go.json down regulation of conjugation|down-regulation of conjugation|downregulation of conjugation|inhibition of conjugation True http://purl.obolibrary.org/obo/GO_0031135 GO:0031136 biolink:BiologicalProcess obsolete positive regulation of conjugation OBSOLETE. Any process that increases the rate or frequency of conjugation. go.json activation of conjugation|stimulation of conjugation|up regulation of conjugation|up-regulation of conjugation|upregulation of conjugation True http://purl.obolibrary.org/obo/GO_0031136 GO:0031133 biolink:BiologicalProcess regulation of axon diameter Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained. go.json http://purl.obolibrary.org/obo/GO_0031133 GO:0031134 biolink:BiologicalProcess sister chromatid biorientation The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. go.json chromosome biorientation|sister kinetochore biorientation http://purl.obolibrary.org/obo/GO_0031134 GO:0031131 biolink:BiologicalProcess reception of an inductive signal The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change. go.json http://purl.obolibrary.org/obo/GO_0031131 GO:0031132 biolink:MolecularActivity serine 3-dehydrogenase activity Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH. EC:1.1.1.276|KEGG_REACTION:R06126|MetaCyc:RXN0-2201|RHEA:21596|Wikipedia:Serine_3-dehydrogenase go.json L-serine:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0031132 GO:0031130 biolink:BiologicalProcess obsolete creation of an inductive signal OBSOLETE. The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter. go.json True http://purl.obolibrary.org/obo/GO_0031130 GO:0031128 biolink:BiologicalProcess developmental induction A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). go.json http://purl.obolibrary.org/obo/GO_0031128 GO:0031129 biolink:BiologicalProcess inductive cell-cell signaling Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate. go.json inductive cell-cell signalling http://purl.obolibrary.org/obo/GO_0031129 GO:0031126 biolink:BiologicalProcess sno(s)RNA 3'-end processing Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea. go.json sRNA 3'-end processing|sno(s)RNA 3' end processing|snoRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0031126 GO:0031127 biolink:MolecularActivity alpha-(1,2)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. go.json alpha-(1->2)-fucosyltransferase activity|alpha-1,2-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0031127 GO:0045732 biolink:BiologicalProcess positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. go.json activation of cellular protein breakdown|activation of cellular protein catabolic process|activation of cellular protein catabolism|activation of cellular protein degradation|activation of protein catabolic process|positive regulation of cellular protein breakdown|positive regulation of cellular protein catabolic process|positive regulation of cellular protein catabolism|positive regulation of cellular protein degradation|positive regulation of cyclin breakdown|positive regulation of cyclin catabolic process|positive regulation of cyclin catabolism|positive regulation of cyclin degradation|positive regulation of degradation of cyclin|positive regulation of protein breakdown|positive regulation of protein catabolism|positive regulation of protein degradation|stimulation of protein catabolic process|up regulation of cellular protein breakdown|up regulation of cellular protein catabolic process|up regulation of cellular protein catabolism|up regulation of cellular protein degradation|up regulation of protein catabolic process|up-regulation of cellular protein breakdown|up-regulation of cellular protein catabolic process|up-regulation of cellular protein catabolism|up-regulation of cellular protein degradation|up-regulation of protein catabolic process|upregulation of cellular protein breakdown|upregulation of cellular protein catabolic process|upregulation of cellular protein catabolism|upregulation of cellular protein degradation|upregulation of protein catabolic process http://purl.obolibrary.org/obo/GO_0045732 GO:0006168 biolink:BiologicalProcess adenine salvage Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. go.json adenine salvage pathway|adenine, hypoxanthine and their nucleoside salvage http://purl.obolibrary.org/obo/GO_0006168 GO:0045733 biolink:BiologicalProcess acetate catabolic process The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. go.json acetate breakdown|acetate catabolism|acetate degradation|homoacetate catabolic process http://purl.obolibrary.org/obo/GO_0045733 GO:0006169 biolink:BiologicalProcess adenosine salvage Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis. go.json adenine, hypoxanthine and their nucleoside salvage http://purl.obolibrary.org/obo/GO_0006169 GO:0006166 biolink:BiologicalProcess purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. MetaCyc:P121-PWY go.json http://purl.obolibrary.org/obo/GO_0006166 GO:0045730 biolink:BiologicalProcess respiratory burst A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Wikipedia:Respiratory_burst go.json metabolic burst|oxidative burst http://purl.obolibrary.org/obo/GO_0045730 GO:0006167 biolink:BiologicalProcess AMP biosynthetic process The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. go.json AMP anabolism|AMP biosynthesis|AMP formation|AMP synthesis http://purl.obolibrary.org/obo/GO_0006167 GO:0045731 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045731 GO:0006164 biolink:BiologicalProcess purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. MetaCyc:DENOVOPURINE2-PWY go.json purine nucleotide anabolism|purine nucleotide biosynthesis|purine nucleotide formation|purine nucleotide synthesis http://purl.obolibrary.org/obo/GO_0006164 GO:0006165 biolink:BiologicalProcess obsolete nucleoside diphosphate phosphorylation OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate. go.json True http://purl.obolibrary.org/obo/GO_0006165 GO:0006162 biolink:BiologicalProcess obsolete purine/pyrimidine nucleoside diphosphate reduction OBSOLETE. (Was not defined before being made obsolete). go.json purine/pyrimidine nucleoside diphosphate reduction True http://purl.obolibrary.org/obo/GO_0006162 GO:0006163 biolink:BiologicalProcess purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine metabolic process|purine metabolism|purine nucleotide metabolism http://purl.obolibrary.org/obo/GO_0006163 GO:0006171 biolink:BiologicalProcess cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json 3',5' cAMP biosynthesis|3',5' cAMP biosynthetic process|3',5'-cAMP biosynthesis|3',5'-cAMP biosynthetic process|adenosine 3',5'-cyclophosphate biosynthesis|adenosine 3',5'-cyclophosphate biosynthetic process|cAMP anabolism|cAMP biosynthesis|cAMP formation|cAMP synthesis|cyclic AMP biosynthesis|cyclic AMP biosynthetic process http://purl.obolibrary.org/obo/GO_0006171 GO:0006172 biolink:BiologicalProcess ADP biosynthetic process The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate. go.json ADP anabolism|ADP biosynthesis|ADP formation|ADP synthesis http://purl.obolibrary.org/obo/GO_0006172 GO:0045738 biolink:BiologicalProcess negative regulation of DNA repair Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. go.json down regulation of DNA repair|down-regulation of DNA repair|downregulation of DNA repair|inhibition of DNA repair http://purl.obolibrary.org/obo/GO_0045738 GO:0006170 biolink:BiologicalProcess dAMP biosynthetic process The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). go.json dAMP anabolism|dAMP biosynthesis|dAMP formation|dAMP synthesis http://purl.obolibrary.org/obo/GO_0006170 GO:0045739 biolink:BiologicalProcess positive regulation of DNA repair Any process that activates or increases the frequency, rate or extent of DNA repair. go.json activation of DNA repair|stimulation of DNA repair|up regulation of DNA repair|up-regulation of DNA repair|upregulation of DNA repair http://purl.obolibrary.org/obo/GO_0045739 GO:0045736 biolink:BiologicalProcess negative regulation of cyclin-dependent protein serine/threonine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0045736 gocheck_do_not_annotate GO:0045737 biolink:BiologicalProcess positive regulation of cyclin-dependent protein serine/threonine kinase activity Any process that activates or increases the frequency, rate or extent of CDK activity. go.json activation of cyclin-dependent protein kinase activity|positive regulation of CDK activity|positive regulation of cyclin-dependent protein kinase activity|stimulation of cyclin-dependent protein kinase activity|up regulation of cyclin-dependent protein kinase activity|up-regulation of cyclin-dependent protein kinase activity|upregulation of cyclin-dependent protein kinase activity http://purl.obolibrary.org/obo/GO_0045737 gocheck_do_not_annotate GO:0045734 biolink:BiologicalProcess regulation of acetate catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. go.json regulation of acetate breakdown|regulation of acetate catabolism|regulation of acetate degradation http://purl.obolibrary.org/obo/GO_0045734 GO:0045735 biolink:MolecularActivity nutrient reservoir activity Functions in the storage of nutritious substrates. go.json storage protein|storage protein of fat body|yolk protein http://purl.obolibrary.org/obo/GO_0045735 goslim_generic|goslim_pir|prokaryote_subset GO:0031124 biolink:BiologicalProcess mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule. go.json mRNA 3' end processing http://purl.obolibrary.org/obo/GO_0031124 GO:0031125 biolink:BiologicalProcess rRNA 3'-end processing Any process involved in forming the mature 3' end of an rRNA molecule. go.json rRNA 3' end processing http://purl.obolibrary.org/obo/GO_0031125 GO:0031122 biolink:BiologicalProcess cytoplasmic microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. go.json cytoplasmic microtubule organisation|cytoplasmic microtubule organization and biogenesis http://purl.obolibrary.org/obo/GO_0031122 GO:0031123 biolink:BiologicalProcess RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. go.json RNA 3' end processing http://purl.obolibrary.org/obo/GO_0031123 GO:0031120 biolink:BiologicalProcess snRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0031120 GO:0031121 biolink:BiologicalProcess equatorial microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell. go.json equatorial microtubule organisation|equatorial microtubule organization and biogenesis http://purl.obolibrary.org/obo/GO_0031121 GO:0021790 biolink:BiologicalProcess chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme http://purl.obolibrary.org/obo/GO_0021790 GO:0021791 biolink:BiologicalProcess chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme http://purl.obolibrary.org/obo/GO_0021791 GO:0021792 biolink:BiologicalProcess chemoattraction of branchiomotor axon The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json positive chemotaxis of branchiomotor axon http://purl.obolibrary.org/obo/GO_0021792 GO:0031119 biolink:BiologicalProcess tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0031119 GO:0021793 biolink:BiologicalProcess chemorepulsion of branchiomotor axon The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. go.json negative chemotaxis of branchiomotor axon http://purl.obolibrary.org/obo/GO_0021793 GO:0021794 biolink:BiologicalProcess thalamus development The process in which the thalamus changes over time, from its initial formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0021794 GO:0031117 biolink:BiologicalProcess positive regulation of microtubule depolymerization Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. go.json activation of microtubule depolymerization|microtubule destabilization|positive regulation of microtubule catastrophe|positive regulation of microtubule disassembly|stimulation of microtubule depolymerization|up regulation of microtubule depolymerization|up-regulation of microtubule depolymerization|upregulation of microtubule depolymerization http://purl.obolibrary.org/obo/GO_0031117 GO:0021795 biolink:BiologicalProcess cerebral cortex cell migration The orderly movement of cells from one site to another in the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021795 GO:0031118 biolink:BiologicalProcess rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0031118 GO:0021796 biolink:BiologicalProcess cerebral cortex regionalization The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops. go.json cerebral cortex arealization|cerebral cortex pattern biosynthesis|cerebral cortex pattern formation http://purl.obolibrary.org/obo/GO_0021796 GO:0031115 biolink:BiologicalProcess negative regulation of microtubule polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. go.json down regulation of microtubule polymerization|down-regulation of microtubule polymerization|downregulation of microtubule polymerization|inhibition of microtubule polymerization http://purl.obolibrary.org/obo/GO_0031115 GO:0031116 biolink:BiologicalProcess positive regulation of microtubule polymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization. go.json activation of microtubule polymerization|stimulation of microtubule polymerization|up regulation of microtubule polymerization|up-regulation of microtubule polymerization|upregulation of microtubule polymerization http://purl.obolibrary.org/obo/GO_0031116 GO:0021797 biolink:BiologicalProcess forebrain anterior/posterior pattern specification The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain. go.json forebrain anterior-posterior pattern specification http://purl.obolibrary.org/obo/GO_0021797 GO:0045743 biolink:BiologicalProcess positive regulation of fibroblast growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. go.json activation of fibroblast growth factor receptor signaling pathway|positive regulation of FGF receptor signaling pathway|positive regulation of FGF receptor signalling pathway|positive regulation of FGFR signaling pathway|stimulation of fibroblast growth factor receptor signaling pathway|up regulation of fibroblast growth factor receptor signaling pathway|up-regulation of fibroblast growth factor receptor signaling pathway|upregulation of fibroblast growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0045743 GO:0006179 biolink:BiologicalProcess guanosine salvage Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis. go.json guanine, xanthine and their nucleoside salvage http://purl.obolibrary.org/obo/GO_0006179 GO:0045744 biolink:BiologicalProcess negative regulation of G protein-coupled receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway. go.json down regulation of G-protein coupled receptor protein signaling pathway|down-regulation of G-protein coupled receptor protein signaling pathway|downregulation of G-protein coupled receptor protein signaling pathway|inhibition of G-protein coupled receptor protein signaling pathway|negative regulation of G protein coupled receptor protein signaling pathway|negative regulation of G protein coupled receptor protein signalling pathway|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of G-protein coupled receptor protein signalling pathway|negative regulation of G-protein-coupled receptor protein signalling pathway|negative regulation of GPCR protein signaling pathway|negative regulation of GPCR protein signalling pathway http://purl.obolibrary.org/obo/GO_0045744 GO:0045741 biolink:BiologicalProcess positive regulation of epidermal growth factor-activated receptor activity Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. go.json activation of epidermal growth factor receptor activity|positive regulation of EGF receptor activity|positive regulation of EGFR activity|positive regulation of epidermal growth factor receptor activity|stimulation of epidermal growth factor receptor activity|up regulation of epidermal growth factor receptor activity|up-regulation of epidermal growth factor receptor activity|upregulation of epidermal growth factor receptor activity http://purl.obolibrary.org/obo/GO_0045741 gocheck_do_not_annotate GO:0006177 biolink:BiologicalProcess GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. go.json GMP anabolism|GMP biosynthesis|GMP formation|GMP synthesis http://purl.obolibrary.org/obo/GO_0006177 GO:0006178 biolink:BiologicalProcess guanine salvage Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis. go.json guanine, xanthine and their nucleoside salvage http://purl.obolibrary.org/obo/GO_0006178 GO:0045742 biolink:BiologicalProcess positive regulation of epidermal growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. go.json activation of epidermal growth factor receptor signaling pathway|positive regulation of EGF receptor signaling pathway|positive regulation of EGF receptor signalling pathway|positive regulation of EGFR signaling pathway|stimulation of epidermal growth factor receptor signaling pathway|up regulation of epidermal growth factor receptor signaling pathway|up-regulation of epidermal growth factor receptor signaling pathway|upregulation of epidermal growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0045742 GO:0006175 biolink:BiologicalProcess dATP biosynthetic process The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). go.json dATP anabolism|dATP biosynthesis|dATP formation|dATP synthesis http://purl.obolibrary.org/obo/GO_0006175 GO:0045740 biolink:BiologicalProcess positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication. go.json activation of DNA replication|stimulation of DNA replication|up regulation of DNA replication|up-regulation of DNA replication|upregulation of DNA replication http://purl.obolibrary.org/obo/GO_0045740 GO:0006176 biolink:BiologicalProcess dATP biosynthetic process from ADP The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate. go.json dATP anabolism from ADP|dATP formation from ADP|dATP synthesis from ADP http://purl.obolibrary.org/obo/GO_0006176 GO:0006173 biolink:BiologicalProcess dADP biosynthetic process The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). go.json dADP anabolism|dADP biosynthesis|dADP formation|dADP synthesis http://purl.obolibrary.org/obo/GO_0006173 GO:0006174 biolink:BiologicalProcess obsolete dADP phosphorylation OBSOLETE. The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP. go.json True http://purl.obolibrary.org/obo/GO_0006174 GO:0006182 biolink:BiologicalProcess cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. go.json cGMP anabolism|cGMP biosynthesis|cGMP formation|cGMP synthesis http://purl.obolibrary.org/obo/GO_0006182 GO:0006183 biolink:BiologicalProcess GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. go.json GTP anabolism|GTP biosynthesis|GTP formation|GTP synthesis http://purl.obolibrary.org/obo/GO_0006183 GO:0006180 biolink:BiologicalProcess deoxyguanosine salvage Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0006180 GO:0045749 biolink:BiologicalProcess obsolete negative regulation of S phase of mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity. go.json down regulation of S phase of mitotic cell cycle|down-regulation of S phase of mitotic cell cycle|downregulation of S phase of mitotic cell cycle|inhibition of S phase of mitotic cell cycle|negative regulation of S phase of mitotic cell cycle|negative regulation of S-phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0045749 GO:0006181 biolink:BiologicalProcess dGMP biosynthetic process The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). go.json dGMP anabolism|dGMP biosynthesis|dGMP formation|dGMP synthesis http://purl.obolibrary.org/obo/GO_0006181 GO:0045747 biolink:BiologicalProcess positive regulation of Notch signaling pathway Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. go.json activation of Notch signaling pathway|positive regulation of N signaling pathway|positive regulation of N signalling pathway|positive regulation of Notch signalling pathway|stimulation of Notch signaling pathway|up regulation of Notch signaling pathway|up-regulation of Notch signaling pathway|upregulation of Notch signaling pathway http://purl.obolibrary.org/obo/GO_0045747 GO:0045748 biolink:BiologicalProcess positive regulation of R8 cell spacing in compound eye Any process that activates or enforces the correct R8 cell spacing in a compound eye. go.json activation of R8 spacing|positive regulation of R8 spacing|stimulation of R8 spacing|up regulation of R8 spacing|up-regulation of R8 spacing|upregulation of R8 spacing http://purl.obolibrary.org/obo/GO_0045748 GO:0045745 biolink:BiologicalProcess positive regulation of G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. go.json activation of G-protein coupled receptor protein signaling pathway|positive regulation of G protein coupled receptor protein signaling pathway|positive regulation of G protein coupled receptor protein signalling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signalling pathway|positive regulation of G-protein-coupled receptor protein signaling pathway|positive regulation of G-protein-coupled receptor protein signalling pathway|positive regulation of GPCR protein signaling pathway|positive regulation of GPCR protein signalling pathway|stimulation of G-protein coupled receptor protein signaling pathway|up regulation of G-protein coupled receptor protein signaling pathway|up-regulation of G-protein coupled receptor protein signaling pathway|upregulation of G-protein coupled receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0045745 GO:0045746 biolink:BiologicalProcess negative regulation of Notch signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. go.json down regulation of Notch signaling pathway|down-regulation of Notch signaling pathway|downregulation of Notch signaling pathway|inhibition of Notch signaling pathway|negative regulation of N signaling pathway|negative regulation of N signalling pathway|negative regulation of Notch signalling pathway http://purl.obolibrary.org/obo/GO_0045746 GO:0021798 biolink:BiologicalProcess forebrain dorsal/ventral pattern formation The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain. go.json forebrain dorsal-ventral pattern formation|forebrain dorsoventral pattern formation http://purl.obolibrary.org/obo/GO_0021798 GO:0031113 biolink:BiologicalProcess regulation of microtubule polymerization Any process that modulates the frequency, rate or extent of microtubule polymerization. go.json http://purl.obolibrary.org/obo/GO_0031113 GO:0031114 biolink:BiologicalProcess regulation of microtubule depolymerization Any process that modulates the frequency, rate or extent of microtubule depolymerization. go.json regulation of microtubule disassembly http://purl.obolibrary.org/obo/GO_0031114 GO:0021799 biolink:BiologicalProcess cerebral cortex radially oriented cell migration The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. go.json http://purl.obolibrary.org/obo/GO_0021799 GO:0031111 biolink:BiologicalProcess negative regulation of microtubule polymerization or depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. go.json down regulation of microtubule polymerization or depolymerization|down-regulation of microtubule polymerization or depolymerization|downregulation of microtubule polymerization or depolymerization|inhibition of microtubule polymerization or depolymerization http://purl.obolibrary.org/obo/GO_0031111 GO:0031112 biolink:BiologicalProcess positive regulation of microtubule polymerization or depolymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. go.json activation of microtubule polymerization or depolymerization|stimulation of microtubule polymerization or depolymerization|up regulation of microtubule polymerization or depolymerization|up-regulation of microtubule polymerization or depolymerization|upregulation of microtubule polymerization or depolymerization http://purl.obolibrary.org/obo/GO_0031112 GO:0031110 biolink:BiologicalProcess regulation of microtubule polymerization or depolymerization Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. go.json http://purl.obolibrary.org/obo/GO_0031110 GO:0080076 biolink:MolecularActivity caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule. go.json http://purl.obolibrary.org/obo/GO_0080076 GO:0080077 biolink:MolecularActivity trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule. go.json http://purl.obolibrary.org/obo/GO_0080077 GO:0080078 biolink:MolecularActivity tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule. go.json http://purl.obolibrary.org/obo/GO_0080078 GO:0080079 biolink:MolecularActivity cellobiose glucosidase activity Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose. MetaCyc:RXN-10773|RHEA:30679 go.json D-cellobiose glucosidase activity|cellobiose glucohydrolase activity http://purl.obolibrary.org/obo/GO_0080079 GO:0080072 biolink:MolecularActivity spermidine:sinapoyl CoA N-acyltransferase activity Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule. go.json http://purl.obolibrary.org/obo/GO_0080072 GO:0080073 biolink:MolecularActivity spermidine:coumaroyl CoA N-acyltransferase activity Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule. go.json http://purl.obolibrary.org/obo/GO_0080073 GO:0080074 biolink:MolecularActivity spermidine:caffeoyl CoA N-acyltransferase activity Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule. go.json http://purl.obolibrary.org/obo/GO_0080074 GO:0080075 biolink:MolecularActivity spermidine:feruloyl CoA N-acyltransferase activity Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule. go.json http://purl.obolibrary.org/obo/GO_0080075 GO:0080070 biolink:MolecularActivity 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate. MetaCyc:RXNQT-4333 go.json http://purl.obolibrary.org/obo/GO_0080070 GO:0080071 biolink:MolecularActivity indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate. MetaCyc:RXN-1443 go.json http://purl.obolibrary.org/obo/GO_0080071 GO:0080069 biolink:MolecularActivity 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate. MetaCyc:RXNQT-4332 go.json http://purl.obolibrary.org/obo/GO_0080069 GO:0080065 biolink:BiologicalProcess 4-alpha-methyl-delta7-sterol oxidation A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O. go.json 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity http://purl.obolibrary.org/obo/GO_0080065 GO:0080066 biolink:MolecularActivity 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate. MetaCyc:RXN-2209 go.json http://purl.obolibrary.org/obo/GO_0080066 GO:0080067 biolink:MolecularActivity 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate. MetaCyc:RXNQT-4329 go.json http://purl.obolibrary.org/obo/GO_0080067 GO:0080068 biolink:MolecularActivity 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate. MetaCyc:RXNQT-4330 go.json http://purl.obolibrary.org/obo/GO_0080068 GO:0080061 biolink:MolecularActivity indole-3-acetonitrile nitrilase activity Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3. EC:3.5.5.1|MetaCyc:RXN-1404|RHEA:45776 go.json http://purl.obolibrary.org/obo/GO_0080061 GO:0080062 biolink:MolecularActivity cytokinin 9-beta-glucosyltransferase activity Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event. KEGG_REACTION:R08369 go.json http://purl.obolibrary.org/obo/GO_0080062 GO:0080063 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080063 GO:0080064 biolink:BiologicalProcess 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O. go.json 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity http://purl.obolibrary.org/obo/GO_0080064 GO:0080060 biolink:BiologicalProcess integument development The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex. go.json http://purl.obolibrary.org/obo/GO_0080060 GO:0080098 biolink:MolecularActivity L-tyrosine:pyruvate aminotransferase activity Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine. EC:2.6.1.58|MetaCyc:RXN3O-4157 go.json http://purl.obolibrary.org/obo/GO_0080098 GO:0080099 biolink:MolecularActivity L-methionine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate. go.json L-methionine:alpha-ketoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0080099 GO:0080094 biolink:BiologicalProcess response to trehalose-6-phosphate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus. go.json response to trehalose-6-phosphate stimulus http://purl.obolibrary.org/obo/GO_0080094 GO:0080095 biolink:MolecularActivity phosphatidylethanolamine-sterol O-acyltransferase activity Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine. go.json http://purl.obolibrary.org/obo/GO_0080095 GO:0080096 biolink:MolecularActivity phosphatidate-sterol O-acyltransferase activity Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate. go.json http://purl.obolibrary.org/obo/GO_0080096 GO:0080097 biolink:MolecularActivity L-tryptophan:pyruvate aminotransferase activity Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine. EC:2.6.1.99|MetaCyc:RXN-10139|RHEA:27586 go.json http://purl.obolibrary.org/obo/GO_0080097 GO:0080090 biolink:BiologicalProcess regulation of primary metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. go.json http://purl.obolibrary.org/obo/GO_0080090 GO:0080091 biolink:BiologicalProcess regulation of raffinose metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose. go.json http://purl.obolibrary.org/obo/GO_0080091 GO:0080092 biolink:BiologicalProcess regulation of pollen tube growth Any process that modulates the frequency, rate or extent of pollen tube growth. go.json http://purl.obolibrary.org/obo/GO_0080092 GO:0080093 biolink:BiologicalProcess regulation of photorespiration Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. go.json http://purl.obolibrary.org/obo/GO_0080093 GO:0080087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080087 GO:0080088 biolink:BiologicalProcess spermidine hydroxycinnamate conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates. go.json http://purl.obolibrary.org/obo/GO_0080088 GO:0080089 biolink:MolecularActivity sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative. go.json http://purl.obolibrary.org/obo/GO_0080089 GO:0080083 biolink:MolecularActivity beta-gentiobiose beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose. go.json http://purl.obolibrary.org/obo/GO_0080083 GO:0080084 biolink:MolecularActivity 5S rDNA binding Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists. go.json http://purl.obolibrary.org/obo/GO_0080084 GO:0080085 biolink:CellularComponent signal recognition particle, chloroplast targeting A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast. go.json http://purl.obolibrary.org/obo/GO_0080085 GO:0080086 biolink:BiologicalProcess stamen filament development The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen. go.json filament development http://purl.obolibrary.org/obo/GO_0080086 GO:0080080 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080080 GO:0080081 biolink:MolecularActivity 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside. go.json http://purl.obolibrary.org/obo/GO_0080081 GO:0080082 biolink:MolecularActivity esculin beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in esculin. go.json http://purl.obolibrary.org/obo/GO_0080082 GO:0031094 biolink:CellularComponent platelet dense tubular network A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. go.json http://purl.obolibrary.org/obo/GO_0031094 goslim_pir GO:0031095 biolink:CellularComponent platelet dense tubular network membrane The lipid bilayer surrounding the platelet dense tubular network. go.json http://purl.obolibrary.org/obo/GO_0031095 GO:0031092 biolink:CellularComponent platelet alpha granule membrane The lipid bilayer surrounding the platelet alpha granule. go.json platelet alpha-granule membrane http://purl.obolibrary.org/obo/GO_0031092 GO:0031093 biolink:CellularComponent platelet alpha granule lumen The volume enclosed by the membrane of the platelet alpha granule. go.json platelet alpha-granule lumen http://purl.obolibrary.org/obo/GO_0031093 GO:0031090 biolink:CellularComponent organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. NIF_Subcellular:sao830981606 go.json intracellular membrane http://purl.obolibrary.org/obo/GO_0031090 GO:0031091 biolink:CellularComponent platelet alpha granule A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). Wikipedia:Platelet_alpha-granule go.json platelet alpha-granule http://purl.obolibrary.org/obo/GO_0031091 GO:0031098 biolink:BiologicalProcess stress-activated protein kinase signaling cascade The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. go.json JNK signaling pathway|JNK signalling pathway|SAPK signaling pathway|SAPK signalling pathway|stress-activated protein kinase signaling pathway|stress-activated protein kinase signalling pathway http://purl.obolibrary.org/obo/GO_0031098 GO:0031099 biolink:BiologicalProcess regeneration The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). Wikipedia:Regeneration_(biology) go.json http://purl.obolibrary.org/obo/GO_0031099 GO:0031096 biolink:CellularComponent platelet dense tubular network lumen The volume enclosed by the membranes of the platelet dense tubular network. go.json http://purl.obolibrary.org/obo/GO_0031096 GO:0031097 biolink:CellularComponent medial cortex A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation. go.json medial ring http://purl.obolibrary.org/obo/GO_0031097 GO:0031083 biolink:CellularComponent BLOC-1 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. go.json http://purl.obolibrary.org/obo/GO_0031083 GO:0031084 biolink:CellularComponent BLOC-2 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru. go.json http://purl.obolibrary.org/obo/GO_0031084 GO:0031081 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031081 GO:0031082 biolink:CellularComponent BLOC complex Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. go.json BLOC-1 related complex http://purl.obolibrary.org/obo/GO_0031082 goslim_pir GO:0031080 biolink:CellularComponent nuclear pore outer ring A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). go.json Nup107-120 complex|Nup107-160 complex|Nup84 complex http://purl.obolibrary.org/obo/GO_0031080 GO:0031089 biolink:CellularComponent platelet dense granule lumen The volume enclosed by the membrane of the platelet dense granule. go.json http://purl.obolibrary.org/obo/GO_0031089 GO:0031087 biolink:BiologicalProcess deadenylation-independent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening. go.json deadenylation-independent decapping of nuclear mRNA|deadenylylation-independent decapping http://purl.obolibrary.org/obo/GO_0031087 GO:0031088 biolink:CellularComponent platelet dense granule membrane The lipid bilayer surrounding the platelet dense granule. go.json http://purl.obolibrary.org/obo/GO_0031088 GO:0031085 biolink:CellularComponent BLOC-3 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins. go.json http://purl.obolibrary.org/obo/GO_0031085 GO:0031086 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, deadenylation-independent decay A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. go.json deadenylation-independent mRNA decay|deadenylylation-independent mRNA decay|mRNA breakdown, deadenylation-independent decay|mRNA catabolic process, deadenylation-independent|mRNA catabolic process, deadenylylation-independent|mRNA catabolism, deadenylation-independent|mRNA catabolism, deadenylation-independent decay|mRNA catabolism, deadenylylation-independent|mRNA degradation, deadenylation-independent decay|nuclear mRNA catabolic process, deadenylation-independent decay http://purl.obolibrary.org/obo/GO_0031086 GO:0031072 biolink:MolecularActivity heat shock protein binding Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. go.json http://purl.obolibrary.org/obo/GO_0031072 GO:0031073 biolink:MolecularActivity cholesterol 26-hydroxylase activity Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol. go.json http://purl.obolibrary.org/obo/GO_0031073 GO:0031070 biolink:BiologicalProcess intronic snoRNA processing The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA. go.json http://purl.obolibrary.org/obo/GO_0031070 GO:0031071 biolink:MolecularActivity cysteine desulfurase activity Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. EC:2.8.1.7|RHEA:43892|Reactome:R-HSA-1362408|Reactome:R-HSA-947514 go.json IscS|L-cysteine:enzyme cysteine sulfurtransferase activity|NIFS|SufS|cysteine desulfurylase activity http://purl.obolibrary.org/obo/GO_0031071 GO:0031078 biolink:MolecularActivity histone H3K14 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. go.json histone H3-K14 deacetylase activity|histone deacetylase activity (H3-K14 specific) http://purl.obolibrary.org/obo/GO_0031078 GO:0031079 biolink:MolecularActivity obsolete picornain 3C activity OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. go.json 3C protease activity|3C proteinase activity|coxsackievirus 3C proteinase activity|cysteine proteinase 3C|foot-and-mouth protease 3C activity|foot-and-mouth-disease virus proteinase 3C|hepatitis A virus 3C proteinase activity|picornain 3C activity|picornavirus endopeptidase 3C activity|poliovirus protease 3C activity|poliovirus proteinase 3C|protease 3C|rhinovirus protease 3C activity|rhinovirus proteinase 3C|tomato ringspot nepovirus 3C-related protease True http://purl.obolibrary.org/obo/GO_0031079 GO:0031076 biolink:BiologicalProcess embryonic camera-type eye development The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. go.json embryonic eye development http://purl.obolibrary.org/obo/GO_0031076 GO:0031077 biolink:BiologicalProcess post-embryonic camera-type eye development The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. go.json post-embryonic camera-style eye development http://purl.obolibrary.org/obo/GO_0031077 GO:0031074 biolink:CellularComponent nucleocytoplasmic transport complex Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores. go.json nucleocytoplasmic shuttling complex http://purl.obolibrary.org/obo/GO_0031074 gocheck_do_not_annotate|goslim_pir GO:0031075 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031075 GO:0070670 biolink:BiologicalProcess response to interleukin-4 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. go.json response to IL-4 http://purl.obolibrary.org/obo/GO_0070670 GO:0021707 biolink:BiologicalProcess cerebellar granule cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021707 GO:0021708 biolink:BiologicalProcess Lugaro cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021708 GO:0055030 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055030 GO:0021709 biolink:BiologicalProcess cerebellar basket cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021709 GO:0055031 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055031 GO:0070679 biolink:MolecularActivity inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate. go.json IP3 binding|InsP3 binding http://purl.obolibrary.org/obo/GO_0070679 GO:0055036 biolink:CellularComponent virion membrane The lipid bilayer surrounding a virion. go.json http://purl.obolibrary.org/obo/GO_0055036 goslim_chembl GO:0070677 biolink:MolecularActivity rRNA (cytosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine. go.json http://purl.obolibrary.org/obo/GO_0070677 GO:0021700 biolink:BiologicalProcess developmental maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0021700 goslim_chembl GO:0055037 biolink:CellularComponent recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. go.json ERC|endosomal recycling compartment|endosome recycling compartment http://purl.obolibrary.org/obo/GO_0055037 GO:0070678 biolink:MolecularActivity preprotein binding Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing. go.json unprocessed protein binding http://purl.obolibrary.org/obo/GO_0070678 GO:0055038 biolink:CellularComponent recycling endosome membrane The lipid bilayer surrounding a recycling endosome. go.json http://purl.obolibrary.org/obo/GO_0055038 GO:0070675 biolink:MolecularActivity hypoxanthine oxidase activity Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2. Reactome:R-HSA-74247 go.json Schardinger enzyme activity|hypoxanthine-xanthine oxidase activity|hypoxanthine:O2 oxidoreductase activity|hypoxanthine:oxygen oxidoreductase activity|schardinger enzyme|xanthine oxidoreductase activity http://purl.obolibrary.org/obo/GO_0070675 GO:0021701 biolink:BiologicalProcess cerebellar Golgi cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021701 GO:0021702 biolink:BiologicalProcess cerebellar Purkinje cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. go.json http://purl.obolibrary.org/obo/GO_0021702 GO:0070676 biolink:BiologicalProcess intralumenal vesicle formation The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome. go.json endosome membrane budding http://purl.obolibrary.org/obo/GO_0070676 GO:0055039 biolink:CellularComponent trichocyst A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in net-like structures, to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft. Wikipedia:Trichocyst go.json http://purl.obolibrary.org/obo/GO_0055039 GO:0055032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055032 GO:0021703 biolink:BiologicalProcess locus ceruleus development The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. go.json locus caeruleus development|locus coeruleus development http://purl.obolibrary.org/obo/GO_0021703 GO:0070673 biolink:BiologicalProcess response to interleukin-18 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. go.json response to IL-18 http://purl.obolibrary.org/obo/GO_0070673 GO:0070674 biolink:MolecularActivity hypoxanthine dehydrogenase activity Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+. Reactome:R-HSA-9727347 go.json NAD-hypoxanthine dehydrogenase activity|hypoxanthine oxidoreductase activity|hypoxanthine-NAD oxidoreductase activity|hypoxanthine/NAD(+) oxidoreductase activity|hypoxanthine/NAD+ oxidoreductase activity|hypoxanthine:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0070674 GO:0055033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055033 GO:0021704 biolink:BiologicalProcess locus ceruleus morphogenesis The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. go.json http://purl.obolibrary.org/obo/GO_0021704 GO:0021705 biolink:BiologicalProcess locus ceruleus formation The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. go.json http://purl.obolibrary.org/obo/GO_0021705 GO:0055034 biolink:BiologicalProcess Bolwig's organ development The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. go.json http://purl.obolibrary.org/obo/GO_0055034 GO:0070671 biolink:BiologicalProcess response to interleukin-12 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. go.json response to IL-12 http://purl.obolibrary.org/obo/GO_0070671 GO:0055035 biolink:CellularComponent plastid thylakoid membrane The lipid bilayer membrane of any thylakoid within a plastid. go.json http://purl.obolibrary.org/obo/GO_0055035 GO:0021706 biolink:BiologicalProcess locus ceruleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. go.json http://purl.obolibrary.org/obo/GO_0021706 GO:0070672 biolink:BiologicalProcess response to interleukin-15 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. go.json response to IL-15 http://purl.obolibrary.org/obo/GO_0070672 GO:0055040 biolink:CellularComponent periplasmic flagellum Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella. go.json http://purl.obolibrary.org/obo/GO_0055040 GO:0055041 biolink:MolecularActivity cyclopentanol dehydrogenase activity Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + H+ + NADH. EC:1.1.1.163|KEGG_REACTION:R02553|MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN|RHEA:11728 go.json cyclopentanol:NAD+ oxidoreductase activity|cyclopentanol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0055041 GO:0055042 biolink:MolecularActivity 5-valerolactone hydrolase activity Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate. go.json http://purl.obolibrary.org/obo/GO_0055042 GO:0070668 biolink:BiologicalProcess positive regulation of mast cell proliferation Any process that activates or increases the rate or extent of mast cell proliferation. go.json activation of mast cell proliferation|stimulation of mast cell proliferation|up regulation of mast cell proliferation|up-regulation of mast cell proliferation|upregulation of mast cell proliferation http://purl.obolibrary.org/obo/GO_0070668 GO:0070669 biolink:BiologicalProcess response to interleukin-2 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. go.json response to IL-2 http://purl.obolibrary.org/obo/GO_0070669 GO:0070666 biolink:BiologicalProcess regulation of mast cell proliferation Any process that modulates the frequency, rate or extent of mast cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0070666 GO:0055047 biolink:BiologicalProcess generative cell mitosis The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells. go.json http://purl.obolibrary.org/obo/GO_0055047 GO:0070667 biolink:BiologicalProcess negative regulation of mast cell proliferation Any process that stops, prevents or reduces the rate or extent of mast cell proliferation. go.json down regulation of mast cell proliferation|down-regulation of mast cell proliferation|downregulation of mast cell proliferation|inhibition of mast cell proliferation http://purl.obolibrary.org/obo/GO_0070667 GO:0055048 biolink:BiologicalProcess anastral spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins. go.json http://purl.obolibrary.org/obo/GO_0055048 GO:0070664 biolink:BiologicalProcess negative regulation of leukocyte proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. go.json down regulation of leukocyte proliferation|down-regulation of leukocyte proliferation|downregulation of leukocyte proliferation|inhibition of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0070664 GO:0055049 biolink:BiologicalProcess obsolete astral spindle assembly OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes. go.json True http://purl.obolibrary.org/obo/GO_0055049 GO:0070665 biolink:BiologicalProcess positive regulation of leukocyte proliferation Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. go.json activation of leukocyte proliferation|stimulation of leukocyte proliferation|up regulation of leukocyte proliferation|up-regulation of leukocyte proliferation|upregulation of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0070665 GO:0070662 biolink:BiologicalProcess mast cell proliferation The expansion of a mast cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0070662 GO:0055043 biolink:MolecularActivity 5-oxovalerate dehydrogenase activity Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+. go.json http://purl.obolibrary.org/obo/GO_0055043 GO:0070663 biolink:BiologicalProcess regulation of leukocyte proliferation Any process that modulates the frequency, rate or extent of leukocyte proliferation. go.json http://purl.obolibrary.org/obo/GO_0070663 GO:0055044 biolink:CellularComponent symplast The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata. Wikipedia:Symplast go.json http://purl.obolibrary.org/obo/GO_0055044 goslim_pir GO:0070660 biolink:BiologicalProcess inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury. go.json http://purl.obolibrary.org/obo/GO_0070660 GO:0055045 biolink:BiologicalProcess antipodal cell degeneration The process in which the antipodal cells undergo programmed cell death. go.json http://purl.obolibrary.org/obo/GO_0055045 GO:0070661 biolink:BiologicalProcess leukocyte proliferation The expansion of a leukocyte population by cell division. go.json http://purl.obolibrary.org/obo/GO_0070661 GO:0055046 biolink:BiologicalProcess microgametogenesis The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure. Wikipedia:Microgametogenesis go.json pollen development from the microspore http://purl.obolibrary.org/obo/GO_0055046 GO:0070691 biolink:CellularComponent P-TEFb complex A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. go.json Bur1/Bur2 complex|Sgv1/Bur2 complex|cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex|cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex|dimeric positive transcription elongation factor complex b http://purl.obolibrary.org/obo/GO_0070691 GO:0070692 biolink:CellularComponent CTDK-1 complex A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638). go.json C-terminal domain kinase I complex|CTDK-I complex|Ctk complex|trimeric positive transcription elongation factor complex b http://purl.obolibrary.org/obo/GO_0070692 GO:0070690 biolink:BiologicalProcess L-threonine catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA. MetaCyc:PWY-5436 go.json L-threonine breakdown to acetyl-CoA|L-threonine catabolism to acetyl-CoA|L-threonine degradation to acetyl-CoA|threonine catabolic process to acetyl-CoA http://purl.obolibrary.org/obo/GO_0070690 GO:0080018 biolink:MolecularActivity anthocyanin 5-O-glucosyltransferase activity Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP. go.json http://purl.obolibrary.org/obo/GO_0080018 GO:0080019 biolink:MolecularActivity alcohol-forming very long-chain fatty acyl-CoA reductase activity Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons. go.json fatty acyl CoA reductase (alcohol-forming) activity|fatty acyl-CoA reductase (alcohol-forming) activity|fatty-acyl-CoA reductase (alcohol-forming) activity http://purl.obolibrary.org/obo/GO_0080019 GO:0080014 biolink:MolecularActivity thalianol hydroxylase activity Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X. EC:1.14.13.-|MetaCyc:RXN-9631 go.json http://purl.obolibrary.org/obo/GO_0080014 GO:0080015 biolink:MolecularActivity sabinene synthase activity Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate. EC:4.2.3.-|MetaCyc:RXN-5103 go.json http://purl.obolibrary.org/obo/GO_0080015 GO:0080016 biolink:MolecularActivity (-)-E-beta-caryophyllene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate. EC:4.2.3.57|MetaCyc:RXN-8414|RHEA:28294 go.json http://purl.obolibrary.org/obo/GO_0080016 GO:0080017 biolink:MolecularActivity alpha-humulene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate. EC:4.2.3.104|MetaCyc:RXN-8415|RHEA:31895 go.json http://purl.obolibrary.org/obo/GO_0080017 GO:0080010 biolink:BiologicalProcess obsolete regulation of oxygen and reactive oxygen species metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH). go.json regulation of oxygen and reactive oxygen species metabolic process True http://purl.obolibrary.org/obo/GO_0080010 GO:0080011 biolink:MolecularActivity baruol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol. EC:5.4.99.57|MetaCyc:RXN-9685|RHEA:31987 go.json http://purl.obolibrary.org/obo/GO_0080011 GO:0080012 biolink:MolecularActivity trihydroxyferuloyl spermidine O-methyltransferase activity Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-11263 go.json N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0080012 GO:0080013 biolink:MolecularActivity (E,E)-geranyllinalool synthase activity Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate. MetaCyc:RXN-10441|RHEA:38155 go.json http://purl.obolibrary.org/obo/GO_0080013 GO:0055050 biolink:BiologicalProcess obsolete astral spindle assembly involved in male meiosis OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells. go.json True http://purl.obolibrary.org/obo/GO_0055050 GO:0055051 biolink:CellularComponent ATP-binding cassette (ABC) transporter complex, integrated substrate binding A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. go.json http://purl.obolibrary.org/obo/GO_0055051 GO:0055052 biolink:CellularComponent ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. go.json http://purl.obolibrary.org/obo/GO_0055052 GO:0055053 biolink:MolecularActivity mannose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+. go.json mannose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0055053 GO:0055058 biolink:BiologicalProcess symmetric neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells. go.json http://purl.obolibrary.org/obo/GO_0055058 GO:0070699 biolink:MolecularActivity type II activin receptor binding Binding to a type II activin receptor. go.json http://purl.obolibrary.org/obo/GO_0070699 GO:0055059 biolink:BiologicalProcess asymmetric neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. go.json http://purl.obolibrary.org/obo/GO_0055059 GO:0070697 biolink:MolecularActivity activin receptor binding Binding to an activin receptor. go.json http://purl.obolibrary.org/obo/GO_0070697 GO:0070698 biolink:MolecularActivity type I activin receptor binding Binding to a type I activin receptor. go.json http://purl.obolibrary.org/obo/GO_0070698 GO:0055054 biolink:MolecularActivity fructose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+. go.json fructose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0055054 GO:0070695 biolink:CellularComponent FHF complex A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex). go.json http://purl.obolibrary.org/obo/GO_0070695 GO:0070696 biolink:MolecularActivity transmembrane receptor protein serine/threonine kinase binding Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0070696 GO:0055055 biolink:MolecularActivity D-glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose. go.json D-glucose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0055055 GO:0070693 biolink:CellularComponent P-TEFb-cap methyltransferase complex A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase. go.json Cdk9-Pcm1 complex|P-TEFb-Pcm1 complex http://purl.obolibrary.org/obo/GO_0070693 GO:0055056 biolink:MolecularActivity D-glucose transmembrane transporter activity Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other. Reactome:R-HSA-429094|Reactome:R-HSA-450095|Reactome:R-HSA-5339524|Reactome:R-HSA-5632804|Reactome:R-HSA-5632871|Reactome:R-HSA-8981553|Reactome:R-HSA-8981564|Reactome:R-HSA-8981570|Reactome:R-HSA-8981574 go.json http://purl.obolibrary.org/obo/GO_0055056 GO:0070694 biolink:MolecularActivity deoxyribonucleoside 5'-monophosphate N-glycosidase activity Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. Reactome:R-HSA-8953339 go.json deoxynucleoside 5'-monophosphate N-glycosidase activity http://purl.obolibrary.org/obo/GO_0070694 GO:0055057 biolink:BiologicalProcess neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. go.json neuroblast cell division http://purl.obolibrary.org/obo/GO_0055057 GO:0070680 biolink:BiologicalProcess asparaginyl-tRNAAsn biosynthesis via transamidation A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase. MetaCyc:PWY490-4 go.json http://purl.obolibrary.org/obo/GO_0070680 GO:0070681 biolink:BiologicalProcess glutaminyl-tRNAGln biosynthesis via transamidation A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase. MetaCyc:PWY-5921 go.json http://purl.obolibrary.org/obo/GO_0070681 GO:0080007 biolink:MolecularActivity S-nitrosoglutathione reductase activity Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+. go.json http://purl.obolibrary.org/obo/GO_0080007 GO:0080008 biolink:CellularComponent Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. go.json http://purl.obolibrary.org/obo/GO_0080008 GO:0080009 biolink:BiologicalProcess mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0080009 GO:0080003 biolink:BiologicalProcess thalianol metabolic process The chemical reactions and pathways involving the triterpene thalianol. go.json thalianol metabolism http://purl.obolibrary.org/obo/GO_0080003 GO:0080004 biolink:MolecularActivity thalian-diol desaturase activity Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15. EC:1.14.21.-|MetaCyc:RXN-9637 go.json http://purl.obolibrary.org/obo/GO_0080004 GO:0080005 biolink:BiologicalProcess photosystem stoichiometry adjustment Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0080005 GO:0080006 biolink:BiologicalProcess internode patterning Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached. go.json http://purl.obolibrary.org/obo/GO_0080006 GO:0080001 biolink:BiologicalProcess mucilage extrusion from seed coat The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat. go.json mucilage release from seed coat|secretion of mucilage from seed coat http://purl.obolibrary.org/obo/GO_0080001 GO:0080002 biolink:MolecularActivity UDP-glucose:4-aminobenzoate acylglucosyltransferase activity Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP. MetaCyc:RXN-6142 go.json UDP-glucose:p-aminobenzoate acylglucosyltransferase activity|UDP-glucose:p-aminobenzoate glucosyltransferase activity|UDP-glucose:pABA acylglucosyltransferase activity http://purl.obolibrary.org/obo/GO_0080002 GO:0055061 biolink:BiologicalProcess obsolete di-, tri-valent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions within an organism or cell. go.json di-, tri-valent inorganic anion homeostasis True http://purl.obolibrary.org/obo/GO_0055061 GO:0055062 biolink:BiologicalProcess phosphate ion homeostasis Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055062 GO:0055063 biolink:BiologicalProcess sulfate ion homeostasis Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell. go.json sulfate homeostasis|sulphate ion homeostasis http://purl.obolibrary.org/obo/GO_0055063 GO:0055064 biolink:BiologicalProcess chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055064 GO:0055060 biolink:BiologicalProcess asymmetric neuroblast division resulting in ganglion mother cell formation Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell. go.json http://purl.obolibrary.org/obo/GO_0055060 GO:0070688 biolink:CellularComponent obsolete MLL5-L complex OBSOLETE. A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively. go.json True http://purl.obolibrary.org/obo/GO_0070688 GO:0055069 biolink:BiologicalProcess obsolete zinc ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. go.json zinc homeostasis True http://purl.obolibrary.org/obo/GO_0055069 GO:0070689 biolink:BiologicalProcess L-threonine catabolic process to propionate The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate. MetaCyc:PWY-5437 go.json L-threonine breakdown to propionate|L-threonine catabolism to propionate|L-threonine degradation to propionate|threonine catabolic process to propionate http://purl.obolibrary.org/obo/GO_0070689 GO:0070686 biolink:CellularComponent macropinocytic cup membrane The portion of the plasma membrane surrounding a macropinocytic cup. go.json crown membrane http://purl.obolibrary.org/obo/GO_0070686 GO:0070687 biolink:CellularComponent macropinocytic cup cytoskeleton The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup. go.json crown cytoskeleton http://purl.obolibrary.org/obo/GO_0070687 GO:0055065 biolink:BiologicalProcess obsolete metal ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0055065 GO:0070684 biolink:BiologicalProcess seminal clot liquefaction The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa. go.json semen liquefaction http://purl.obolibrary.org/obo/GO_0070684 GO:0070685 biolink:CellularComponent macropinocytic cup A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin. go.json crown http://purl.obolibrary.org/obo/GO_0070685 GO:0055066 biolink:BiologicalProcess obsolete di-, tri-valent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations within an organism or cell. go.json di-, tri-valent inorganic cation homeostasis True http://purl.obolibrary.org/obo/GO_0055066 GO:0055067 biolink:BiologicalProcess obsolete monovalent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0055067 GO:0070682 biolink:BiologicalProcess proteasome regulatory particle assembly The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex. go.json proteasome regulatory complex assembly http://purl.obolibrary.org/obo/GO_0070682 GO:0055068 biolink:BiologicalProcess cobalt ion homeostasis Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell. go.json cobalt homeostasis http://purl.obolibrary.org/obo/GO_0055068 GO:0070683 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070683 GO:0080036 biolink:BiologicalProcess regulation of cytokinin-activated signaling pathway Any process that modulates the frequency, rate or extent of cytokinin signaling. go.json regulation of cytokinin mediated signaling pathway|regulation of cytokinin mediated signalling http://purl.obolibrary.org/obo/GO_0080036 GO:0080037 biolink:BiologicalProcess negative regulation of cytokinin-activated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinin signaling. go.json negative regulation of cytokinin mediated signaling pathway|negative regulation of cytokinin mediated signalling http://purl.obolibrary.org/obo/GO_0080037 GO:0080038 biolink:BiologicalProcess positive regulation of cytokinin-activated signaling pathway Any process that activates or increases the frequency, rate or extent of cytokinin signaling. go.json positive regulation of cytokinin mediated signaling pathway|positive regulation of cytokinin mediated signalling http://purl.obolibrary.org/obo/GO_0080038 GO:0080039 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080039 GO:0080032 biolink:MolecularActivity methyl jasmonate esterase activity Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol. MetaCyc:RXN-10767 go.json MEJA esterase activity|jasmonic acid methyl ester esterase activity|methyl JA esterase activity http://purl.obolibrary.org/obo/GO_0080032 GO:0080033 biolink:BiologicalProcess response to nitrite Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus. go.json http://purl.obolibrary.org/obo/GO_0080033 GO:0080034 biolink:BiologicalProcess host response to induction by symbiont of tumor, nodule or growth in host Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0080034 GO:0080035 biolink:BiologicalProcess 2-hydroxy-but-3-enyl glucosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables. go.json 2-hydroxy-but-3-enyl glucosinolate anabolism|2-hydroxy-but-3-enyl glucosinolate biosynthesis|2-hydroxy-but-3-enyl glucosinolate formation|2-hydroxy-but-3-enyl glucosinolate synthesis|progoitrin biosynthesis|progoitrin biosynthetic process|progoitrin synthesis http://purl.obolibrary.org/obo/GO_0080035 GO:0055072 biolink:BiologicalProcess obsolete iron ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. go.json iron homeostasis True http://purl.obolibrary.org/obo/GO_0055072 GO:0055073 biolink:BiologicalProcess obsolete cadmium ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell. go.json cadmium homeostasis True http://purl.obolibrary.org/obo/GO_0055073 GO:0055074 biolink:BiologicalProcess calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. go.json regulation of calcium ion concentration http://purl.obolibrary.org/obo/GO_0055074 GO:0080030 biolink:MolecularActivity methyl indole-3-acetate esterase activity Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+. MetaCyc:RXN-10711 go.json MeIAA esterase activity|Methyl IAA esterase activity|indole-3-Acetic acid methyl ester esterase activity http://purl.obolibrary.org/obo/GO_0080030 GO:0055075 biolink:BiologicalProcess potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055075 GO:0080031 biolink:MolecularActivity methyl salicylate esterase activity Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+. MetaCyc:RXNQT-4366 go.json MESA esterase activity|methyl SA esterase activity|methylsalicylate esterase activity|salicylic acid methyl ester esterase activity http://purl.obolibrary.org/obo/GO_0080031 GO:0055070 biolink:BiologicalProcess copper ion homeostasis Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. go.json copper homeostasis http://purl.obolibrary.org/obo/GO_0055070 GO:0055071 biolink:BiologicalProcess manganese ion homeostasis Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell. go.json manganese homeostasis http://purl.obolibrary.org/obo/GO_0055071 GO:0055076 biolink:BiologicalProcess obsolete transition metal ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. go.json True http://purl.obolibrary.org/obo/GO_0055076 GO:0055077 biolink:MolecularActivity gap junction hemi-channel activity A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. go.json connexon channel activity http://purl.obolibrary.org/obo/GO_0055077 GO:0055078 biolink:BiologicalProcess sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055078 GO:0055079 biolink:BiologicalProcess obsolete aluminum ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell. go.json aluminium ion homeostasis True http://purl.obolibrary.org/obo/GO_0055079 GO:0080029 biolink:BiologicalProcess cellular response to boron-containing substance levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances. go.json cellular response to boron levels http://purl.obolibrary.org/obo/GO_0080029 GO:0080025 biolink:MolecularActivity phosphatidylinositol-3,5-bisphosphate binding Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. go.json PtdIns(3,5)P2 binding http://purl.obolibrary.org/obo/GO_0080025 GO:0080026 biolink:BiologicalProcess response to indolebutyric acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus. go.json response to IBA stimulus|response to indole-3-butyric acid stimulus|response to indolebutyric acid stimulus http://purl.obolibrary.org/obo/GO_0080026 GO:0080027 biolink:BiologicalProcess response to herbivore Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore. go.json http://purl.obolibrary.org/obo/GO_0080027 GO:0080028 biolink:BiologicalProcess nitrile biosynthetic process The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. go.json http://purl.obolibrary.org/obo/GO_0080028 GO:0080021 biolink:BiologicalProcess response to benzoic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus. go.json response to benzoic acid stimulus http://purl.obolibrary.org/obo/GO_0080021 GO:0080022 biolink:BiologicalProcess primary root development The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle. go.json http://purl.obolibrary.org/obo/GO_0080022 GO:0080023 biolink:MolecularActivity obsolete (3R)-3-hydroxyacyl-CoA dehydratase activity OBSOLETE. Catalysis of the reaction: a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. go.json 3R-hydroxyacyl-CoA dehydratase activity True http://purl.obolibrary.org/obo/GO_0080023 GO:0080024 biolink:BiologicalProcess indolebutyric acid metabolic process The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants. go.json IBA metabolic process|IBA metabolism|indole-3-butyric acid metabolic process http://purl.obolibrary.org/obo/GO_0080024 GO:0055083 biolink:BiologicalProcess obsolete monovalent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0055083 GO:0055084 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055084 GO:0055085 biolink:BiologicalProcess transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. go.json ATP hydrolysis coupled transmembrane transport|membrane transport http://purl.obolibrary.org/obo/GO_0055085 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pombe|goslim_yeast GO:0055086 biolink:BiologicalProcess nucleobase-containing small molecule metabolic process The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. go.json nucleobase, nucleoside and nucleotide metabolic process|nucleobase, nucleoside and nucleotide metabolism http://purl.obolibrary.org/obo/GO_0055086 goslim_drosophila|goslim_generic|goslim_pombe|goslim_yeast|prokaryote_subset GO:0080020 biolink:BiologicalProcess regulation of coenzyme A biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A. go.json http://purl.obolibrary.org/obo/GO_0080020 GO:0055080 biolink:BiologicalProcess monoatomic cation homeostasis Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom. go.json cation homeostasis http://purl.obolibrary.org/obo/GO_0055080 GO:0055081 biolink:BiologicalProcess monoatomic anion homeostasis Any process involved in the maintenance of an internal steady state of monoatomic anions within an organism or cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom. go.json anion homeostasis http://purl.obolibrary.org/obo/GO_0055081 GO:0055082 biolink:BiologicalProcess intracellular chemical homeostasis A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell. go.json cellular chemical homeostasis http://purl.obolibrary.org/obo/GO_0055082 GO:0055087 biolink:CellularComponent Ski complex A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p. Wikipedia:Ski_complex go.json http://purl.obolibrary.org/obo/GO_0055087 GO:0055088 biolink:BiologicalProcess lipid homeostasis Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055088 GO:0055089 biolink:BiologicalProcess fatty acid homeostasis Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055089 GO:0080058 biolink:BiologicalProcess protein deglutathionylation The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage. go.json protein amino acid deglutathionylation http://purl.obolibrary.org/obo/GO_0080058 gocheck_do_not_annotate GO:0080059 biolink:MolecularActivity flavonol 3-O-arabinosyltransferase activity Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside. go.json http://purl.obolibrary.org/obo/GO_0080059 GO:0080054 biolink:MolecularActivity low-affinity nitrate transmembrane transporter activity Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity nitrate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0080054 GO:0080055 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080055 GO:0080056 biolink:BiologicalProcess petal vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the petal of vascular plants. go.json http://purl.obolibrary.org/obo/GO_0080056 GO:0080057 biolink:BiologicalProcess sepal vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the sepal of vascular plants. go.json http://purl.obolibrary.org/obo/GO_0080057 GO:0080050 biolink:BiologicalProcess regulation of seed development Any process that modulates the frequency, rate or extent of seed development. go.json http://purl.obolibrary.org/obo/GO_0080050 GO:0055094 biolink:BiologicalProcess response to lipoprotein particle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. go.json response to lipoprotein particle stimulus http://purl.obolibrary.org/obo/GO_0055094 GO:0055095 biolink:BiologicalProcess lipoprotein particle mediated signaling The series of molecular signals mediated by the detection of a lipoprotein particle. go.json lipoprotein mediated signalling|lipoprotein particle mediated signal transduction|lipoprotein particle-mediated signaling http://purl.obolibrary.org/obo/GO_0055095 GO:0080051 biolink:BiologicalProcess cutin transport The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface. go.json http://purl.obolibrary.org/obo/GO_0080051 GO:0055096 biolink:BiologicalProcess low-density lipoprotein particle mediated signaling The series of molecular signals mediated by the detection of low-density lipoprotein particle. go.json low-density lipoprotein mediated signalling|low-density lipoprotein particle mediated signal transduction|low-density lipoprotein particle-mediated signaling http://purl.obolibrary.org/obo/GO_0055096 GO:0080052 biolink:BiologicalProcess response to histidine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus. go.json http://purl.obolibrary.org/obo/GO_0080052 GO:0080053 biolink:BiologicalProcess response to phenylalanine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus. go.json http://purl.obolibrary.org/obo/GO_0080053 GO:0055097 biolink:BiologicalProcess high density lipoprotein particle mediated signaling The series of molecular signals mediated by the detection of high density lipoprotein particle. go.json high density lipoprotein mediated signalling|high density lipoprotein particle mediated signal transduction|high density lipoprotein particle-mediated signaling http://purl.obolibrary.org/obo/GO_0055097 GO:0055090 biolink:BiologicalProcess acylglycerol homeostasis Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. go.json glyceride homeostasis http://purl.obolibrary.org/obo/GO_0055090 GO:0055091 biolink:BiologicalProcess phospholipid homeostasis Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055091 GO:0055092 biolink:BiologicalProcess sterol homeostasis Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0055092 GO:0055093 biolink:BiologicalProcess response to hyperoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. go.json response to hyperoxic stress|response to increased oxygen tension http://purl.obolibrary.org/obo/GO_0055093 GO:0055098 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055098 GO:0055099 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055099 GO:0080047 biolink:MolecularActivity GDP-L-galactose phosphorylase activity Catalysis of the reaction: GDP-beta-L-galactose + phosphate = beta-L-galactose-1-phosphate + GDP. EC:2.7.7.69|MetaCyc:RXNQT-4141|RHEA:27698 go.json GDP:galactose-1-phosphate guanyltransferase activity|galactose-1-phosphate guanylyltransferase (GDP) activity http://purl.obolibrary.org/obo/GO_0080047 GO:0080048 biolink:MolecularActivity GDP-D-glucose phosphorylase activity Catalysis of the reaction: GDP-alpha-D-glucose + phosphate = alpha-D-glucose-1-phosphate + GDP. EC:2.7.7.78|MetaCyc:RXN-12486|RHEA:30387 go.json GDP:glucose-1-phosphate guanyltransferase activity|glucose-1-phosphate guanylyltransferase (GDP) activity http://purl.obolibrary.org/obo/GO_0080048 GO:0080049 biolink:MolecularActivity L-gulono-1,4-lactone dehydrogenase activity Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. MetaCyc:RXN-1439 go.json http://purl.obolibrary.org/obo/GO_0080049 GO:0080043 biolink:MolecularActivity quercetin 3-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule. go.json http://purl.obolibrary.org/obo/GO_0080043 GO:0080044 biolink:MolecularActivity quercetin 7-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule. go.json http://purl.obolibrary.org/obo/GO_0080044 GO:0080045 biolink:MolecularActivity quercetin 3'-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule. go.json http://purl.obolibrary.org/obo/GO_0080045 GO:0080046 biolink:MolecularActivity quercetin 4'-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule. MetaCyc:RXN-10788 go.json http://purl.obolibrary.org/obo/GO_0080046 GO:0080040 biolink:BiologicalProcess positive regulation of cellular response to phosphate starvation Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation. go.json http://purl.obolibrary.org/obo/GO_0080040 GO:0080041 biolink:MolecularActivity ADP-ribose pyrophosphohydrolase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate. go.json http://purl.obolibrary.org/obo/GO_0080041 GO:0080042 biolink:MolecularActivity ADP-glucose pyrophosphohydrolase activity Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate. go.json http://purl.obolibrary.org/obo/GO_0080042 GO:0031229 biolink:CellularComponent obsolete intrinsic component of nuclear inner membrane OBSOLETE. The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to nuclear inner membrane True http://purl.obolibrary.org/obo/GO_0031229 GO:0031227 biolink:CellularComponent obsolete intrinsic component of endoplasmic reticulum membrane OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to endoplasmic reticulum membrane True http://purl.obolibrary.org/obo/GO_0031227 GO:0031228 biolink:CellularComponent obsolete intrinsic component of Golgi membrane OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to Golgi membrane True http://purl.obolibrary.org/obo/GO_0031228 GO:0031225 biolink:CellularComponent obsolete anchored component of membrane OBSOLETE. The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json anchored to membrane True http://purl.obolibrary.org/obo/GO_0031225 GO:0006269 biolink:BiologicalProcess DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. go.json replication priming http://purl.obolibrary.org/obo/GO_0006269 GO:0031226 biolink:CellularComponent obsolete intrinsic component of plasma membrane OBSOLETE. The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to plasma membrane True http://purl.obolibrary.org/obo/GO_0031226 GO:0045875 biolink:BiologicalProcess negative regulation of sister chromatid cohesion Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion. go.json down regulation of sister chromatid cohesion|down-regulation of sister chromatid cohesion|downregulation of sister chromatid cohesion|inhibition of sister chromatid cohesion http://purl.obolibrary.org/obo/GO_0045875 GO:0006267 biolink:BiologicalProcess pre-replicative complex assembly involved in nuclear cell cycle DNA replication The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation. go.json nuclear pre-replicative complex assembly|pre-RC complex assembly|pre-replicative complex assembly|pre-replicative complex formation http://purl.obolibrary.org/obo/GO_0006267 GO:0045876 biolink:BiologicalProcess positive regulation of sister chromatid cohesion Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion. go.json activation of sister chromatid cohesion|stimulation of sister chromatid cohesion|up regulation of sister chromatid cohesion|up-regulation of sister chromatid cohesion|upregulation of sister chromatid cohesion http://purl.obolibrary.org/obo/GO_0045876 GO:0006268 biolink:BiologicalProcess DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. go.json DNA unwinding during replication|DNA unwinding factor http://purl.obolibrary.org/obo/GO_0006268 GO:0045873 biolink:BiologicalProcess negative regulation of sevenless signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway. go.json down regulation of sevenless signaling pathway|down-regulation of sevenless signaling pathway|downregulation of sevenless signaling pathway|inhibition of sevenless signaling pathway|negative regulation of sev signaling pathway|negative regulation of sevenless signalling pathway http://purl.obolibrary.org/obo/GO_0045873 GO:0006265 biolink:BiologicalProcess DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. go.json DNA underwinding http://purl.obolibrary.org/obo/GO_0006265 GO:0045874 biolink:BiologicalProcess positive regulation of sevenless signaling pathway Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway. go.json activation of sevenless signaling pathway|positive regulation of sev signaling pathway|positive regulation of sevenless signalling pathway|stimulation of sevenless signaling pathway|up regulation of sevenless signaling pathway|up-regulation of sevenless signaling pathway|upregulation of sevenless signaling pathway http://purl.obolibrary.org/obo/GO_0045874 GO:0006266 biolink:BiologicalProcess DNA ligation The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. go.json http://purl.obolibrary.org/obo/GO_0006266 goslim_pir GO:0045871 biolink:BiologicalProcess obsolete negative regulation of rhodopsin gene expression OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression. go.json down regulation of rhodopsin gene activity|down-regulation of rhodopsin gene activity|downregulation of rhodopsin gene activity|inhibition of rhodopsin gene activity|negative regulation of rhodopsin gene activity True http://purl.obolibrary.org/obo/GO_0045871 GO:0006263 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006263 GO:0006264 biolink:BiologicalProcess mitochondrial DNA replication The process in which new strands of DNA are synthesized in the mitochondrion. go.json mitochondrial DNA synthesis|mtDNA replication|mtDNA synthesis|replication of mitochondrial DNA http://purl.obolibrary.org/obo/GO_0006264 GO:0045872 biolink:BiologicalProcess obsolete positive regulation of rhodopsin gene expression OBSOLETE. Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression. go.json activation of rhodopsin gene activity|positive regulation of rhodopsin gene activity|stimulation of rhodopsin gene activity|up regulation of rhodopsin gene activity|up-regulation of rhodopsin gene activity|upregulation of rhodopsin gene activity True http://purl.obolibrary.org/obo/GO_0045872 GO:0006261 biolink:BiologicalProcess DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. go.json DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0006261 GO:0045870 biolink:BiologicalProcess positive regulation of single stranded viral RNA replication via double stranded DNA intermediate Any process that activates or increases the frequency, rate or extent of retroviral genome replication. go.json activation of retroviral genome replication|positive regulation of retroviral genome replication|stimulation of retroviral genome replication|up regulation of retroviral genome replication|up-regulation of retroviral genome replication|upregulation of retroviral genome replication http://purl.obolibrary.org/obo/GO_0045870 GO:0006262 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006262 GO:0006270 biolink:BiologicalProcess DNA replication initiation The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. go.json DNA endoreduplication initiation|DNA re-replication initiation|DNA-dependent DNA replication initiation http://purl.obolibrary.org/obo/GO_0006270 GO:0070839 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070839 GO:0006271 biolink:BiologicalProcess DNA strand elongation involved in DNA replication The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. go.json DNA replication elongation|DNA strand elongation during DNA replication http://purl.obolibrary.org/obo/GO_0006271 GO:0070837 biolink:BiologicalProcess dehydroascorbic acid transport The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C. go.json dehydroascorbate transport http://purl.obolibrary.org/obo/GO_0070837 GO:0070838 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070838 GO:0045879 biolink:BiologicalProcess negative regulation of smoothened signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. go.json down regulation of smoothened signaling pathway|down-regulation of smoothened signaling pathway|downregulation of smoothened signaling pathway|inhibition of smoothened signaling pathway|negative regulation of hedgehog signaling pathway|negative regulation of hh signaling pathway|negative regulation of smoothened activity|negative regulation of smoothened by patched|negative regulation of smoothened receptor activity by patched|negative regulation of smoothened signalling pathway http://purl.obolibrary.org/obo/GO_0045879 GO:0070835 biolink:MolecularActivity chromium ion transmembrane transporter activity Enables the transfer of chromium (Cr) ions from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0070835 GO:0070836 biolink:BiologicalProcess caveola assembly The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. go.json caveola formation|caveolar biogenesis http://purl.obolibrary.org/obo/GO_0070836 GO:0070833 biolink:BiologicalProcess phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine. MetaCyc:PWY4FS-3 go.json http://purl.obolibrary.org/obo/GO_0070833 GO:0045877 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045877 GO:0070834 biolink:BiologicalProcess phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine. MetaCyc:PWY4FS-4 go.json http://purl.obolibrary.org/obo/GO_0070834 GO:0045878 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045878 GO:0070831 biolink:BiologicalProcess basement membrane assembly The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. go.json http://purl.obolibrary.org/obo/GO_0070831 GO:0031223 biolink:BiologicalProcess auditory behavior The behavior of an organism in response to a sound. go.json auditory behaviour|behavioral response to sound|behavioural response to sound http://purl.obolibrary.org/obo/GO_0031223 GO:0031224 biolink:CellularComponent obsolete intrinsic component of membrane OBSOLETE. The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. go.json intrinsic to membrane True http://purl.obolibrary.org/obo/GO_0031224 GO:0070832 biolink:BiologicalProcess phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine. MetaCyc:PWY4FS-2 go.json http://purl.obolibrary.org/obo/GO_0070832 GO:0031221 biolink:BiologicalProcess arabinan metabolic process The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues. go.json arabinan metabolism http://purl.obolibrary.org/obo/GO_0031221 GO:0070830 biolink:BiologicalProcess bicellular tight junction assembly The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. go.json tight junction formation http://purl.obolibrary.org/obo/GO_0070830 GO:0031222 biolink:BiologicalProcess arabinan catabolic process The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues. go.json arabinan breakdown|arabinan catabolism|arabinan degradation http://purl.obolibrary.org/obo/GO_0031222 GO:0031220 biolink:MolecularActivity maltodextrin phosphorylase activity Catalysis of the reaction: maltodextrin = glucose-1-phosphate. MetaCyc:RXN-9025|MetaCyc:RXN0-5182|RHEA:29691 go.json http://purl.obolibrary.org/obo/GO_0031220 GO:0021890 biolink:BiologicalProcess olfactory bulb interneuron fate commitment The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb. go.json http://purl.obolibrary.org/obo/GO_0021890 GO:0021891 biolink:BiologicalProcess olfactory bulb interneuron development The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0021891 GO:0031218 biolink:MolecularActivity arabinogalactan endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. EC:3.2.1.89|MetaCyc:3.2.1.89-RXN go.json arabinogalactan 4-beta-D-galactanohydrolase activity|arabinogalactanase activity|endo-1,4-beta-galactanase activity|galactanase activity http://purl.obolibrary.org/obo/GO_0031218 GO:0021892 biolink:BiologicalProcess cerebral cortex GABAergic interneuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021892 GO:0031219 biolink:MolecularActivity levanase activity Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units. EC:3.2.1.65|MetaCyc:3.2.1.65-RXN go.json 2,6-beta-D-fructan fructanohydrolase activity|levan hydrolase activity http://purl.obolibrary.org/obo/GO_0031219 GO:0021893 biolink:BiologicalProcess cerebral cortex GABAergic interneuron fate commitment The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021893 GO:0031216 biolink:MolecularActivity neopullulanase activity Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose). EC:3.2.1.135|MetaCyc:3.2.1.135-RXN go.json pullulan 4-D-glucanohydrolase (panose-forming)|pullulanase II activity http://purl.obolibrary.org/obo/GO_0031216 GO:0021894 biolink:BiologicalProcess cerebral cortex GABAergic interneuron development The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0021894 GO:0031217 biolink:MolecularActivity glucan 1,4-beta-glucosidase activity Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units. EC:3.2.1.74|MetaCyc:3.2.1.74-RXN go.json 1,4-beta-D-glucan glucohydrolase activity|beta-1,4-beta-glucanase activity|beta-1,4-glucanase activity|exo-1,4-beta-D-glucosidase activity|exo-1,4-beta-glucanase activity|exo-1,4-beta-glucosidase activity|exo-beta-1,4-glucanase activity|exo-beta-1,4-glucosidase activity|exocellulase activity http://purl.obolibrary.org/obo/GO_0031217 GO:0021895 biolink:BiologicalProcess cerebral cortex neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021895 GO:0031214 biolink:BiologicalProcess biomineral tissue development Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. Wikipedia:Biomineralization go.json http://purl.obolibrary.org/obo/GO_0031214 GO:0021896 biolink:BiologicalProcess forebrain astrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. go.json http://purl.obolibrary.org/obo/GO_0021896 GO:0031215 biolink:BiologicalProcess shell calcification The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell. go.json http://purl.obolibrary.org/obo/GO_0031215 GO:0045886 biolink:BiologicalProcess negative regulation of synaptic assembly at neuromuscular junction Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic assembly at neuromuscular junction. go.json down regulation of synaptic growth at neuromuscular junction|down-regulation of synaptic growth at neuromuscular junction|downregulation of synaptic growth at neuromuscular junction|inhibition of synaptic growth at neuromuscular junction|negative regulation of synaptic growth at neuromuscular junction http://purl.obolibrary.org/obo/GO_0045886 GO:0006278 biolink:BiologicalProcess RNA-templated DNA biosynthetic process A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. go.json RNA-dependent DNA biosynthetic process http://purl.obolibrary.org/obo/GO_0006278 GO:0006279 biolink:BiologicalProcess premeiotic DNA replication The replication of DNA that precedes meiotic cell division. go.json DNA replication during S phase involved in meiotic cell cycle|DNA replication involved in S phase involved in meiotic cell cycle|DNA replication involved in S-phase involved in meiotic cell cycle|meiotic DNA replication|meiotic DNA synthesis|meiotic cell cycle DNA replication|meiotic nuclear cell cycle DNA replication|nuclear cell cycle DNA replication involved in meiotic cell cycle|premeiotic DNA synthesis http://purl.obolibrary.org/obo/GO_0006279 GO:0045887 biolink:BiologicalProcess positive regulation of synaptic assembly at neuromuscular junction Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction. go.json activation of synaptic growth at neuromuscular junction|positive regulation of synaptic growth at neuromuscular junction|stimulation of synaptic growth at neuromuscular junction|up regulation of synaptic growth at neuromuscular junction|up-regulation of synaptic growth at neuromuscular junction|upregulation of synaptic growth at neuromuscular junction http://purl.obolibrary.org/obo/GO_0045887 GO:0006276 biolink:BiologicalProcess plasmid maintenance The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. go.json http://purl.obolibrary.org/obo/GO_0006276 goslim_pir GO:0045884 biolink:BiologicalProcess obsolete regulation of survival gene product expression OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level. go.json regulation of survival gene product activity|regulation of survival gene product expression|regulation of survival gene products True http://purl.obolibrary.org/obo/GO_0045884 GO:0045885 biolink:BiologicalProcess obsolete positive regulation of survival gene product expression OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level. go.json activation of survival gene product activity|positive regulation of survival gene product activity|positive regulation of survival gene product expression|positive regulation of survival gene products|stimulation of survival gene product activity|up regulation of survival gene product activity|up-regulation of survival gene product activity|upregulation of survival gene product activity True http://purl.obolibrary.org/obo/GO_0045885 GO:0006277 biolink:BiologicalProcess DNA amplification The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. go.json http://purl.obolibrary.org/obo/GO_0006277 GO:0045882 biolink:BiologicalProcess negative regulation of sulfur utilization Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization. go.json down regulation of sulfur utilization|down-regulation of sulfur utilization|downregulation of sulfur utilization|inhibition of sulfur utilization|negative regulation of sulphur utilization http://purl.obolibrary.org/obo/GO_0045882 GO:0006274 biolink:BiologicalProcess DNA replication termination The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. go.json http://purl.obolibrary.org/obo/GO_0006274 GO:0045883 biolink:BiologicalProcess positive regulation of sulfur utilization Any process that activates or increases the frequency, rate or extent of sulfur utilization. go.json activation of sulfur utilization|positive regulation of sulphur utilization|stimulation of sulfur utilization|up regulation of sulfur utilization|up-regulation of sulfur utilization|upregulation of sulfur utilization http://purl.obolibrary.org/obo/GO_0045883 GO:0006275 biolink:BiologicalProcess regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. go.json http://purl.obolibrary.org/obo/GO_0006275 GO:0045880 biolink:BiologicalProcess positive regulation of smoothened signaling pathway Any process that activates or increases the frequency, rate or extent of smoothened signaling. go.json activation of smoothened signaling pathway|positive regulation of hedgehog signaling pathway|positive regulation of hh signaling pathway|positive regulation of smoothened by patched|positive regulation of smoothened receptor activity by patched|positive regulation of smoothened signalling pathway|stimulation of smoothened signaling pathway|up regulation of smoothened signaling pathway|up-regulation of smoothened signaling pathway|upregulation of smoothened signaling pathway http://purl.obolibrary.org/obo/GO_0045880 GO:0006272 biolink:BiologicalProcess leading strand elongation The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork. go.json http://purl.obolibrary.org/obo/GO_0006272 GO:0070819 biolink:MolecularActivity menaquinone-dependent protoporphyrinogen oxidase activity Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone. go.json protoporphyrinogen-IX:menaquinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0070819 GO:0045881 biolink:BiologicalProcess positive regulation of sporulation resulting in formation of a cellular spore Any process that activates or increases the frequency, rate or extent of sporulation. go.json activation of sporulation|stimulation of sporulation|up regulation of sporulation|up-regulation of sporulation|upregulation of sporulation http://purl.obolibrary.org/obo/GO_0045881 GO:0006273 biolink:BiologicalProcess lagging strand elongation The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. go.json http://purl.obolibrary.org/obo/GO_0006273 GO:0006281 biolink:BiologicalProcess DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. Wikipedia:DNA_repair go.json http://purl.obolibrary.org/obo/GO_0006281 goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast|prokaryote_subset GO:0070828 biolink:BiologicalProcess heterochromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. go.json heterochromatin organisation http://purl.obolibrary.org/obo/GO_0070828 GO:0070829 biolink:BiologicalProcess obsolete heterochromatin maintenance OBSOLETE. The chromatin organization process that preserves heterochromatin in a stable functional or structural state. go.json heterochromatin maintenance involved in chromatin silencing|maintenance of chromatin silencing|maintenance of heterochromatic silencing True http://purl.obolibrary.org/obo/GO_0070829 GO:0006282 biolink:BiologicalProcess regulation of DNA repair Any process that modulates the frequency, rate or extent of DNA repair. go.json http://purl.obolibrary.org/obo/GO_0006282 goslim_metagenomics GO:0070826 biolink:CellularComponent paraferritin complex A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme. go.json http://purl.obolibrary.org/obo/GO_0070826 GO:0070827 biolink:BiologicalProcess obsolete chromatin maintenance OBSOLETE. The chromatin organization process that preserves chromatin in a stable functional or structural state. go.json True http://purl.obolibrary.org/obo/GO_0070827 GO:0006280 biolink:BiologicalProcess obsolete mutagenesis OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level. go.json mutagenesis True http://purl.obolibrary.org/obo/GO_0006280 GO:0070824 biolink:CellularComponent SHREC complex A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures. go.json Snf2/HDAC containing repressor complex|Snf2/Hdac repressive complex http://purl.obolibrary.org/obo/GO_0070824 GO:0070825 biolink:CellularComponent chrorion micropyle A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization. go.json http://purl.obolibrary.org/obo/GO_0070825 GO:0070822 biolink:CellularComponent Sin3-type complex Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. go.json http://purl.obolibrary.org/obo/GO_0070822 GO:0045888 biolink:BiologicalProcess obsolete regulation of transcription of homeotic gene (Polycomb group) OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group. go.json regulation of transcription of homeotic gene (Polycomb group) True http://purl.obolibrary.org/obo/GO_0045888 GO:0045889 biolink:BiologicalProcess obsolete positive regulation of transcription of homeotic gene (Polycomb group) OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group. go.json positive regulation of transcription of homeotic gene (Polycomb group) True http://purl.obolibrary.org/obo/GO_0045889 GO:0070823 biolink:CellularComponent HDA1 complex A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p. go.json http://purl.obolibrary.org/obo/GO_0070823 GO:0070820 biolink:CellularComponent tertiary granule A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. go.json gelatinase granule http://purl.obolibrary.org/obo/GO_0070820 GO:0031212 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031212 GO:0021897 biolink:BiologicalProcess forebrain astrocyte development The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. go.json http://purl.obolibrary.org/obo/GO_0021897 GO:0031213 biolink:CellularComponent RSF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters). go.json remodeling and spacing factor complex http://purl.obolibrary.org/obo/GO_0031213 GO:0021898 biolink:BiologicalProcess commitment of multipotent stem cells to neuronal lineage in forebrain The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021898 GO:0070821 biolink:CellularComponent tertiary granule membrane The lipid bilayer surrounding a tertiary granule. go.json http://purl.obolibrary.org/obo/GO_0070821 GO:0021899 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. go.json fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment http://purl.obolibrary.org/obo/GO_0021899 GO:0031210 biolink:MolecularActivity phosphatidylcholine binding Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. go.json http://purl.obolibrary.org/obo/GO_0031210 GO:0031211 biolink:CellularComponent endoplasmic reticulum palmitoyltransferase complex A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. go.json http://purl.obolibrary.org/obo/GO_0031211 GO:0031209 biolink:CellularComponent SCAR complex A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. go.json WAVE complex|WAVE regulatory complex|WRC http://purl.obolibrary.org/obo/GO_0031209 GO:0045890 biolink:BiologicalProcess obsolete regulation of transcription of homeotic gene (trithorax group) OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group. go.json regulation of transcription of homeotic gene (trithorax group) True http://purl.obolibrary.org/obo/GO_0045890 GO:0021880 biolink:BiologicalProcess Notch signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. go.json Notch signalling pathway involved in forebrain neuron fate commitment http://purl.obolibrary.org/obo/GO_0021880 GO:0031207 biolink:CellularComponent Sec62/Sec63 complex A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p. go.json ER protein translocation subcomplex|Sec62/63 complex http://purl.obolibrary.org/obo/GO_0031207 GO:0031208 biolink:MolecularActivity POZ domain binding Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. go.json BTB domain|broad-complex, tramtrack, and bric-a-brac domain binding http://purl.obolibrary.org/obo/GO_0031208 GO:0021881 biolink:BiologicalProcess Wnt-activated signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain. go.json Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signalling pathway involved in forebrain neuron fate commitment http://purl.obolibrary.org/obo/GO_0021881 GO:0006249 biolink:BiologicalProcess dCMP catabolic process The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate. go.json dCMP breakdown|dCMP catabolism|dCMP degradation http://purl.obolibrary.org/obo/GO_0006249 GO:0031205 biolink:CellularComponent endoplasmic reticulum Sec complex An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. go.json http://purl.obolibrary.org/obo/GO_0031205 goslim_pir GO:0021882 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. go.json True http://purl.obolibrary.org/obo/GO_0021882 GO:0021883 biolink:BiologicalProcess obsolete cell cycle arrest of committed forebrain neuronal progenitor cell OBSOLETE. The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain. go.json True http://purl.obolibrary.org/obo/GO_0021883 GO:0031206 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031206 GO:0006247 biolink:BiologicalProcess obsolete TTP reduction OBSOLETE. (Was not defined before being made obsolete). go.json TTP reduction True http://purl.obolibrary.org/obo/GO_0006247 GO:0021884 biolink:BiologicalProcess forebrain neuron development The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0021884 GO:0031203 biolink:BiologicalProcess post-translational protein targeting to membrane, docking The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex. go.json Sec-translated protein complex assembly|posttranslational protein membrane targeting, docking|posttranslational protein targeting to membrane, docking|protein docking during posttranslational protein targeting to membrane http://purl.obolibrary.org/obo/GO_0031203 GO:0006248 biolink:BiologicalProcess CMP catabolic process The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate. go.json CMP breakdown|CMP catabolism|CMP degradation http://purl.obolibrary.org/obo/GO_0006248 GO:0021885 biolink:BiologicalProcess forebrain cell migration The orderly movement of a cell from one site to another at least one of which is located in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021885 GO:0031204 biolink:BiologicalProcess post-translational protein targeting to membrane, translocation The process in which a protein translocates through the ER membrane posttranslationally. go.json posttranslational protein membrane targeting, translocation|posttranslational protein targeting to membrane, translocation|protein translocation during posttranslational protein targeting to membrane http://purl.obolibrary.org/obo/GO_0031204 GO:0006245 biolink:BiologicalProcess TDP catabolic process The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate. go.json TDP breakdown|TDP catabolism|TDP degradation http://purl.obolibrary.org/obo/GO_0006245 GO:0045897 biolink:BiologicalProcess obsolete positive regulation of transcription during mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription that occurs during the mitotic cell cycle. go.json activation of transcription during mitosis|mitotic activation of transcription|positive regulation of transcription, mitotic|stimulation of transcription during mitosis|up regulation of transcription during mitosis|up-regulation of transcription during mitosis|upregulation of transcription during mitosis True http://purl.obolibrary.org/obo/GO_0045897 GO:0006246 biolink:BiologicalProcess dTDP catabolic process The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate. go.json dTDP breakdown|dTDP catabolism|dTDP degradation http://purl.obolibrary.org/obo/GO_0006246 GO:0045898 biolink:BiologicalProcess regulation of RNA polymerase II transcription preinitiation complex assembly Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. go.json regulation of RNA polymerase II transcriptional pre-initiation complex assembly|regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis|regulation of RNA polymerase II transcriptional preinitiation complex assembly|regulation of RNA polymerase II transcriptional preinitiation complex formation http://purl.obolibrary.org/obo/GO_0045898 GO:0045895 biolink:BiologicalProcess positive regulation of mating-type specific transcription, DNA-templated Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription. go.json activation of transcription, mating-type specific|positive regulation of mating-type specific transcription, DNA-dependent|stimulation of transcription, mating-type specific|up regulation of transcription, mating-type specific|up-regulation of transcription, mating-type specific|upregulation of transcription, mating-type specific http://purl.obolibrary.org/obo/GO_0045895 GO:0006243 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006243 GO:0006244 biolink:BiologicalProcess pyrimidine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine nucleotide breakdown|pyrimidine nucleotide catabolism|pyrimidine nucleotide degradation http://purl.obolibrary.org/obo/GO_0006244 GO:0045896 biolink:BiologicalProcess obsolete regulation of transcription during mitotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription that occurs during the mitotic cell cycle. go.json mitotic regulation of transcription|regulation of transcription, mitotic True http://purl.obolibrary.org/obo/GO_0045896 GO:0045893 biolink:BiologicalProcess positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. go.json activation of gene-specific transcription|activation of transcription, DNA-dependent|positive regulation of cellular transcription, DNA-dependent|positive regulation of gene-specific transcription|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-templated|stimulation of gene-specific transcription|stimulation of transcription, DNA-dependent|transcription activator activity|up regulation of gene-specific transcription|up regulation of transcription, DNA-dependent|up-regulation of gene-specific transcription|up-regulation of transcription, DNA-dependent|upregulation of gene-specific transcription|upregulation of transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0045893 GO:0006241 biolink:BiologicalProcess CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. go.json CTP anabolism|CTP biosynthesis|CTP formation|CTP synthesis http://purl.obolibrary.org/obo/GO_0006241 GO:0045894 biolink:BiologicalProcess negative regulation of mating-type specific transcription, DNA-templated Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription. go.json down regulation of transcription, mating-type specific|down-regulation of transcription, mating-type specific|downregulation of transcription, mating-type specific|inhibition of transcription, mating-type specific|negative regulation of mating-type specific transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0045894 GO:0006242 biolink:BiologicalProcess dCTP biosynthetic process The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate. go.json dCTP anabolism|dCTP biosynthesis|dCTP formation|dCTP synthesis http://purl.obolibrary.org/obo/GO_0006242 GO:0045891 biolink:BiologicalProcess obsolete negative regulation of transcription of homeotic gene (trithorax group) OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group. go.json negative regulation of transcription of homeotic gene (trithorax group) True http://purl.obolibrary.org/obo/GO_0045891 GO:0045892 biolink:BiologicalProcess negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. go.json down regulation of gene-specific transcription|down regulation of transcription, DNA-dependent|down-regulation of gene-specific transcription|down-regulation of transcription, DNA-dependent|downregulation of gene-specific transcription|downregulation of transcription, DNA-dependent|inhibition of gene-specific transcription|inhibition of transcription, DNA-dependent|negative regulation of cellular transcription, DNA-dependent|negative regulation of gene-specific transcription|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-templated|transcription repressor activity http://purl.obolibrary.org/obo/GO_0045892 GO:0006240 biolink:BiologicalProcess dCDP biosynthetic process The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate. go.json dCDP anabolism|dCDP biosynthesis|dCDP formation|dCDP synthesis http://purl.obolibrary.org/obo/GO_0006240 GO:0070859 biolink:BiologicalProcess positive regulation of bile acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. go.json activation of bile acid biosynthetic process|positive regulation of bile acid anabolism|positive regulation of bile acid biosynthesis|positive regulation of bile acid formation|positive regulation of bile acid synthesis|stimulation of bile acid biosynthetic process|up regulation of bile acid biosynthetic process|up-regulation of bile acid biosynthetic process|upregulation of bile acid biosynthetic process http://purl.obolibrary.org/obo/GO_0070859 GO:0070857 biolink:BiologicalProcess regulation of bile acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. go.json regulation of bile acid anabolism|regulation of bile acid biosynthesis|regulation of bile acid formation|regulation of bile acid synthesis http://purl.obolibrary.org/obo/GO_0070857 GO:0070858 biolink:BiologicalProcess negative regulation of bile acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. go.json down regulation of bile acid biosynthetic process|down-regulation of bile acid biosynthetic process|downregulation of bile acid biosynthetic process|inhibition of bile acid biosynthetic process|negative regulation of bile acid anabolism|negative regulation of bile acid biosynthesis|negative regulation of bile acid formation|negative regulation of bile acid synthesis http://purl.obolibrary.org/obo/GO_0070858 GO:0045899 biolink:BiologicalProcess positive regulation of RNA polymerase II transcription preinitiation complex assembly Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. go.json activation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly|positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex formation|stimulation of RNA polymerase II transcriptional preinitiation complex assembly|up regulation of RNA polymerase II transcriptional preinitiation complex assembly|up-regulation of RNA polymerase II transcriptional preinitiation complex assembly|upregulation of RNA polymerase II transcriptional preinitiation complex assembly http://purl.obolibrary.org/obo/GO_0045899 GO:0070855 biolink:MolecularActivity myosin VI head/neck binding Binding to the head/neck region of a myosin VI heavy chain. go.json http://purl.obolibrary.org/obo/GO_0070855 GO:0070856 biolink:MolecularActivity myosin VI light chain binding Binding to a light chain of a myosin VI complex. go.json http://purl.obolibrary.org/obo/GO_0070856 GO:0070853 biolink:MolecularActivity myosin VI binding Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. go.json http://purl.obolibrary.org/obo/GO_0070853 GO:0031201 biolink:CellularComponent SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. go.json http://purl.obolibrary.org/obo/GO_0031201 GO:0021886 biolink:BiologicalProcess hypothalamus gonadotrophin-releasing hormone neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter. go.json hypothalamus gonadotropin-releasing hormone neuron differentiation http://purl.obolibrary.org/obo/GO_0021886 GO:0021887 biolink:BiologicalProcess hypothalamus gonadotrophin-releasing hormone neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone. go.json hypothalamus gonadotropin-releasing hormone neuron fate commitment http://purl.obolibrary.org/obo/GO_0021887 GO:0070854 biolink:MolecularActivity myosin VI heavy chain binding Binding to a heavy chain of a myosin VI complex. go.json http://purl.obolibrary.org/obo/GO_0070854 GO:0031202 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031202 GO:0070851 biolink:MolecularActivity growth factor receptor binding Binding to a growth factor receptor. go.json http://purl.obolibrary.org/obo/GO_0070851 GO:0021888 biolink:BiologicalProcess hypothalamus gonadotrophin-releasing hormone neuron development The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell. go.json hypothalamus gonadotropin-releasing hormone neuron development http://purl.obolibrary.org/obo/GO_0021888 GO:0070852 biolink:CellularComponent cell body fiber A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches. go.json cell body fibre|primary neurite http://purl.obolibrary.org/obo/GO_0070852 GO:0031200 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031200 GO:0021889 biolink:BiologicalProcess olfactory bulb interneuron differentiation The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. go.json http://purl.obolibrary.org/obo/GO_0021889 GO:0070850 biolink:CellularComponent TACC/TOG complex A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase. go.json http://purl.obolibrary.org/obo/GO_0070850 GO:0021870 biolink:BiologicalProcess Cajal-Retzius cell differentiation The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene. go.json http://purl.obolibrary.org/obo/GO_0021870 GO:0021871 biolink:BiologicalProcess forebrain regionalization The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. go.json http://purl.obolibrary.org/obo/GO_0021871 GO:0021872 biolink:BiologicalProcess forebrain generation of neurons The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. go.json generation of neurons in forebrain http://purl.obolibrary.org/obo/GO_0021872 GO:0006258 biolink:BiologicalProcess UDP-glucose catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. go.json UDP-glucose breakdown|UDP-glucose catabolism|UDP-glucose conversion|UDP-glucose degradation http://purl.obolibrary.org/obo/GO_0006258 GO:0021873 biolink:BiologicalProcess forebrain neuroblast division The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast. go.json http://purl.obolibrary.org/obo/GO_0021873 GO:0006259 biolink:BiologicalProcess DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. go.json DNA metabolism|cellular DNA metabolism http://purl.obolibrary.org/obo/GO_0006259 goslim_agr|goslim_candida|goslim_chembl|goslim_flybase_ribbon|goslim_metagenomics|goslim_pir|goslim_plant GO:0021874 biolink:BiologicalProcess Wnt signaling pathway involved in forebrain neuroblast division The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. go.json Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signalling pathway in forebrain neuroblast division|Wnt-activated signaling pathway involved in forebrain neuroblast division http://purl.obolibrary.org/obo/GO_0021874 GO:0006256 biolink:BiologicalProcess UDP catabolic process The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate. go.json UDP breakdown|UDP catabolism|UDP degradation http://purl.obolibrary.org/obo/GO_0006256 GO:0006257 biolink:BiologicalProcess dUDP catabolic process The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate. go.json dUDP breakdown|dUDP catabolism|dUDP degradation http://purl.obolibrary.org/obo/GO_0006257 GO:0006254 biolink:BiologicalProcess CTP catabolic process The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate. go.json CTP breakdown|CTP catabolism|CTP degradation|CTP hydrolysis http://purl.obolibrary.org/obo/GO_0006254 GO:0006255 biolink:BiologicalProcess obsolete UDP reduction OBSOLETE. (Was not defined before being made obsolete). go.json UDP reduction True http://purl.obolibrary.org/obo/GO_0006255 GO:0006252 biolink:BiologicalProcess obsolete CTP reduction OBSOLETE. (Was not defined before being made obsolete). go.json CTP reduction True http://purl.obolibrary.org/obo/GO_0006252 GO:0006253 biolink:BiologicalProcess dCTP catabolic process The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate. go.json dCTP breakdown|dCTP catabolism|dCTP degradation http://purl.obolibrary.org/obo/GO_0006253 GO:0006250 biolink:BiologicalProcess obsolete CDP reduction OBSOLETE. (Was not defined before being made obsolete). go.json CDP reduction True http://purl.obolibrary.org/obo/GO_0006250 GO:0006251 biolink:BiologicalProcess dCDP catabolic process The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate. go.json dCDP breakdown|dCDP catabolism|dCDP degradation http://purl.obolibrary.org/obo/GO_0006251 GO:0006260 biolink:BiologicalProcess DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. Wikipedia:DNA_replication go.json http://purl.obolibrary.org/obo/GO_0006260 goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast|prokaryote_subset GO:0070848 biolink:BiologicalProcess response to growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. go.json response to growth factor stimulus http://purl.obolibrary.org/obo/GO_0070848 GO:0070849 biolink:BiologicalProcess response to epidermal growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. go.json response to EGF stimulus|response to epidermal growth factor stimulus http://purl.obolibrary.org/obo/GO_0070849 GO:0070846 biolink:BiologicalProcess Hsp90 deacetylation The modification of an Hsp90 protein by removal of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0070846 gocheck_do_not_annotate GO:0070847 biolink:CellularComponent core mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. go.json C mediator complex|S mediator complex http://purl.obolibrary.org/obo/GO_0070847 GO:0070844 biolink:BiologicalProcess polyubiquitinated protein transport The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. go.json polyubiquitylated protein transport http://purl.obolibrary.org/obo/GO_0070844 GO:0070845 biolink:BiologicalProcess polyubiquitinated misfolded protein transport The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. go.json misfolded polyubiquitinated protein transport|polyubiquitylated misfolded protein transport http://purl.obolibrary.org/obo/GO_0070845 GO:0070842 biolink:BiologicalProcess aggresome assembly The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein. go.json http://purl.obolibrary.org/obo/GO_0070842 GO:0021875 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain. go.json fibroblast growth factor receptor signalling pathway in forebrain neuroblast division http://purl.obolibrary.org/obo/GO_0021875 GO:0070843 biolink:BiologicalProcess misfolded protein transport The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. go.json http://purl.obolibrary.org/obo/GO_0070843 GO:0021876 biolink:BiologicalProcess Notch signaling pathway involved in forebrain neuroblast division The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. go.json Notch signalling pathway in forebrain neuroblast division http://purl.obolibrary.org/obo/GO_0021876 GO:0070840 biolink:MolecularActivity dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. go.json dynein binding http://purl.obolibrary.org/obo/GO_0070840 GO:0021877 biolink:BiologicalProcess forebrain neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021877 GO:0070841 biolink:BiologicalProcess inclusion body assembly The aggregation, arrangement and bonding together of a set of components to form an inclusion body. go.json http://purl.obolibrary.org/obo/GO_0070841 GO:0021878 biolink:BiologicalProcess forebrain astrocyte fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021878 GO:0021879 biolink:BiologicalProcess forebrain neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021879 GO:0006229 biolink:BiologicalProcess dUTP biosynthetic process The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate. go.json dUTP anabolism|dUTP biosynthesis|dUTP formation|dUTP synthesis http://purl.obolibrary.org/obo/GO_0006229 GO:0006227 biolink:BiologicalProcess dUDP biosynthetic process The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate). go.json dUDP anabolism|dUDP biosynthesis|dUDP formation|dUDP synthesis http://purl.obolibrary.org/obo/GO_0006227 GO:0021860 biolink:BiologicalProcess pyramidal neuron development The progression of a pyramidal neuron from its initial formation to its mature state. go.json projection neuron development http://purl.obolibrary.org/obo/GO_0021860 GO:0021861 biolink:BiologicalProcess forebrain radial glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json radial glial cell differentiation in forebrain http://purl.obolibrary.org/obo/GO_0021861 GO:0006228 biolink:BiologicalProcess UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. go.json UTP anabolism|UTP biosynthesis|UTP formation|UTP synthesis http://purl.obolibrary.org/obo/GO_0006228 GO:0006225 biolink:BiologicalProcess UDP biosynthetic process The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate. go.json UDP anabolism|UDP biosynthesis|UDP formation|UDP synthesis http://purl.obolibrary.org/obo/GO_0006225 GO:0021862 biolink:BiologicalProcess early neuron differentiation in forebrain The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021862 GO:0021863 biolink:BiologicalProcess forebrain neuroblast differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json abventricular progenitor cell differentiation|intermediate progenitor cell differentiation|non-surface dividing progenitor cell differentiation http://purl.obolibrary.org/obo/GO_0021863 GO:0006226 biolink:BiologicalProcess dUMP biosynthetic process The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). go.json dUMP anabolism|dUMP biosynthesis|dUMP formation|dUMP synthesis http://purl.obolibrary.org/obo/GO_0006226 GO:0006223 biolink:BiologicalProcess uracil salvage Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0006223 GO:0006224 biolink:BiologicalProcess obsolete uridine kinase reaction OBSOLETE. (Was not defined before being made obsolete). go.json uridine kinase reaction True http://purl.obolibrary.org/obo/GO_0006224 GO:0006221 biolink:BiologicalProcess pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine nucleotide anabolism|pyrimidine nucleotide biosynthesis|pyrimidine nucleotide formation|pyrimidine nucleotide synthesis http://purl.obolibrary.org/obo/GO_0006221 GO:0006222 biolink:BiologicalProcess UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. go.json UMP anabolism|UMP biosynthesis|UMP formation|UMP synthesis http://purl.obolibrary.org/obo/GO_0006222 GO:0006220 biolink:BiologicalProcess pyrimidine nucleotide metabolic process The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine metabolic process|pyrimidine metabolism|pyrimidine nucleotide metabolism http://purl.obolibrary.org/obo/GO_0006220 GO:0070879 biolink:BiologicalProcess fungal-type cell wall beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. go.json fungal-type cell wall beta-glucan metabolism http://purl.obolibrary.org/obo/GO_0070879 GO:0070877 biolink:CellularComponent microprocessor complex A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs. go.json http://purl.obolibrary.org/obo/GO_0070877 GO:0070878 biolink:MolecularActivity primary miRNA binding Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. go.json pri-miRNA binding|primary microRNA binding http://purl.obolibrary.org/obo/GO_0070878 GO:0021864 biolink:BiologicalProcess obsolete radial glial cell division in forebrain OBSOLETE. The mitotic division of radial glial cells in the developing forebrain. go.json True http://purl.obolibrary.org/obo/GO_0021864 GO:0070875 biolink:BiologicalProcess positive regulation of glycogen metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. go.json positive regulation of glycogen metabolism http://purl.obolibrary.org/obo/GO_0070875 GO:0070876 biolink:CellularComponent SOSS complex A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. go.json http://purl.obolibrary.org/obo/GO_0070876 GO:0021865 biolink:BiologicalProcess obsolete symmetric radial glial cell division in forebrain OBSOLETE. The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain. go.json True http://purl.obolibrary.org/obo/GO_0021865 GO:0070873 biolink:BiologicalProcess regulation of glycogen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. go.json regulation of glycogen metabolism http://purl.obolibrary.org/obo/GO_0070873 GO:0021866 biolink:BiologicalProcess obsolete asymmetric radial glial cell division in forebrain OBSOLETE. The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type. go.json True http://purl.obolibrary.org/obo/GO_0021866 GO:0070874 biolink:BiologicalProcess negative regulation of glycogen metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. go.json negative regulation of glycogen metabolism http://purl.obolibrary.org/obo/GO_0070874 GO:0021867 biolink:BiologicalProcess obsolete neuron-producing asymmetric radial glial cell division in forebrain OBSOLETE. The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor. go.json True http://purl.obolibrary.org/obo/GO_0021867 GO:0021868 biolink:BiologicalProcess obsolete ventricular zone cell-producing asymmetric radial glial cell division in forebrain OBSOLETE. The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell. go.json True http://purl.obolibrary.org/obo/GO_0021868 GO:0070871 biolink:BiologicalProcess cell wall organization involved in conjugation with cellular fusion A process of cell wall organization that contributes to conjugation with cellular fusion. go.json cell wall organisation involved in conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0070871 GO:0021869 biolink:BiologicalProcess forebrain ventricular zone progenitor cell division The mitotic division of a basal progenitor giving rise to two neurons. go.json http://purl.obolibrary.org/obo/GO_0021869 GO:0070872 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070872 GO:0070870 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070870 GO:0006238 biolink:BiologicalProcess CMP salvage Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis. go.json cytidine monophosphate salvage http://purl.obolibrary.org/obo/GO_0006238 GO:0006239 biolink:BiologicalProcess dCMP salvage Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis. go.json deoxycytidine monophosphate salvage http://purl.obolibrary.org/obo/GO_0006239 GO:0021850 biolink:BiologicalProcess subpallium glioblast cell division The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes. go.json glioblast cell division in subpallium|glioblast division in ventral telencephalon http://purl.obolibrary.org/obo/GO_0021850 GO:0006236 biolink:BiologicalProcess cytidine salvage Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0006236 GO:0021851 biolink:BiologicalProcess neuroblast division in dorsal lateral ganglionic eminence The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb. go.json http://purl.obolibrary.org/obo/GO_0021851 GO:0021852 biolink:BiologicalProcess pyramidal neuron migration to cerebral cortex The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex. go.json projection neuron migration|pyramidal neuron migration http://purl.obolibrary.org/obo/GO_0021852 GO:0006237 biolink:BiologicalProcess deoxycytidine salvage Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0006237 GO:0006234 biolink:BiologicalProcess TTP biosynthetic process The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate. go.json TTP anabolism|TTP biosynthesis|TTP formation|TTP synthesis http://purl.obolibrary.org/obo/GO_0006234 GO:0006235 biolink:BiologicalProcess dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. go.json dTTP anabolism|dTTP biosynthesis|dTTP formation|dTTP synthesis http://purl.obolibrary.org/obo/GO_0006235 GO:0006232 biolink:BiologicalProcess TDP biosynthetic process The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate. go.json TDP anabolism|TDP biosynthesis|TDP formation|TDP synthesis http://purl.obolibrary.org/obo/GO_0006232 GO:0006233 biolink:BiologicalProcess dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). go.json dTDP anabolism|dTDP biosynthesis|dTDP formation|dTDP synthesis http://purl.obolibrary.org/obo/GO_0006233 GO:0006230 biolink:BiologicalProcess TMP biosynthetic process The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate. go.json TMP anabolism|TMP biosynthesis|TMP formation|TMP synthesis http://purl.obolibrary.org/obo/GO_0006230 GO:0006231 biolink:BiologicalProcess dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). go.json dTMP anabolism|dTMP biosynthesis|dTMP formation|dTMP synthesis http://purl.obolibrary.org/obo/GO_0006231 GO:0070868 biolink:BiologicalProcess obsolete heterochromatin organization involved in chromatin silencing OBSOLETE. Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing. go.json heterochromatin organisation involved in chromatin silencing True http://purl.obolibrary.org/obo/GO_0070868 GO:0070869 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070869 GO:0070866 biolink:MolecularActivity sterol-dependent protein binding Binding to a protein or protein complex in the presence of sterols. go.json http://purl.obolibrary.org/obo/GO_0070866 GO:0070867 biolink:CellularComponent mating projection tip membrane The portion of the plasma membrane surrounding a mating projection tip. go.json mating projection membrane fusion domain|shmoo tip membrane http://purl.obolibrary.org/obo/GO_0070867 GO:0070864 biolink:CellularComponent sperm individualization complex A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst. go.json http://purl.obolibrary.org/obo/GO_0070864 GO:0021853 biolink:BiologicalProcess cerebral cortex GABAergic interneuron migration The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021853 GO:0070865 biolink:CellularComponent investment cone A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization. go.json F-actin cone http://purl.obolibrary.org/obo/GO_0070865 GO:0021854 biolink:BiologicalProcess hypothalamus development The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0021854 GO:0070862 biolink:BiologicalProcess negative regulation of protein exit from endoplasmic reticulum Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. go.json down regulation of protein exit from endoplasmic reticulum|down-regulation of protein exit from endoplasmic reticulum|downregulation of protein exit from endoplasmic reticulum|inhibition of protein exit from endoplasmic reticulum|negative regulation of protein exit from ER|negative regulation of protein export from ER|negative regulation of protein export from endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0070862 GO:0021855 biolink:BiologicalProcess hypothalamus cell migration The directed movement of a cell into the hypothalamus region of the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021855 GO:0070863 biolink:BiologicalProcess positive regulation of protein exit from endoplasmic reticulum Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum. go.json activation of protein exit from endoplasmic reticulum|positive regulation of protein exit from ER|positive regulation of protein export from ER|positive regulation of protein export from endoplasmic reticulum|stimulation of protein exit from endoplasmic reticulum|up regulation of protein exit from endoplasmic reticulum|up-regulation of protein exit from endoplasmic reticulum|upregulation of protein exit from endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0070863 GO:0021856 biolink:BiologicalProcess hypothalamic tangential migration using cell-axon interactions The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons. go.json http://purl.obolibrary.org/obo/GO_0021856 GO:0070860 biolink:CellularComponent RNA polymerase I core factor complex A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p. go.json http://purl.obolibrary.org/obo/GO_0070860 GO:0021857 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0021857 GO:0070861 biolink:BiologicalProcess regulation of protein exit from endoplasmic reticulum Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. go.json regulation of protein exit from ER|regulation of protein export from ER|regulation of protein export from endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0070861 GO:0021858 biolink:BiologicalProcess GABAergic neuron differentiation in basal ganglia The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron. go.json http://purl.obolibrary.org/obo/GO_0021858 GO:0021859 biolink:BiologicalProcess pyramidal neuron differentiation The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron. go.json projection neuron differentiation http://purl.obolibrary.org/obo/GO_0021859 GO:0006209 biolink:BiologicalProcess cytosine catabolic process The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. go.json cytosine breakdown|cytosine catabolism|cytosine degradation http://purl.obolibrary.org/obo/GO_0006209 GO:0070890 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070890 GO:0006207 biolink:BiologicalProcess 'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. go.json 'de novo' pyrimidine base anabolism|'de novo' pyrimidine base biosynthesis|'de novo' pyrimidine base biosynthetic process|'de novo' pyrimidine base formation|'de novo' pyrimidine base synthesis http://purl.obolibrary.org/obo/GO_0006207 GO:0006208 biolink:BiologicalProcess pyrimidine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. go.json pyrimidine base breakdown|pyrimidine base catabolic process|pyrimidine base catabolism|pyrimidine base degradation http://purl.obolibrary.org/obo/GO_0006208 GO:0006205 biolink:BiologicalProcess obsolete pyrimidine metabolic process OBSOLETE. (Was not defined before being made obsolete). go.json pyrimidine metabolic process True http://purl.obolibrary.org/obo/GO_0006205 GO:0006206 biolink:BiologicalProcess pyrimidine nucleobase metabolic process The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. go.json pyrimidine base metabolic process|pyrimidine base metabolism|pyrimidine metabolic process|pyrimidine metabolism http://purl.obolibrary.org/obo/GO_0006206 GO:0006203 biolink:BiologicalProcess dGTP catabolic process The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. go.json dGTP breakdown|dGTP catabolism|dGTP degradation http://purl.obolibrary.org/obo/GO_0006203 GO:0021840 biolink:BiologicalProcess directional guidance of interneurons involved in migration from the subpallium to the cortex The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex. go.json http://purl.obolibrary.org/obo/GO_0021840 GO:0006204 biolink:BiologicalProcess IMP catabolic process The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate. go.json IMP breakdown|IMP catabolism|IMP degradation http://purl.obolibrary.org/obo/GO_0006204 GO:0021841 biolink:BiologicalProcess chemoattraction involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex. go.json positive chemotaxis involved in interneuron migration from the subpallium to the cortex http://purl.obolibrary.org/obo/GO_0021841 GO:0006201 biolink:BiologicalProcess GMP catabolic process to IMP The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate. go.json GMP breakdown to IMP|GMP degradation to IMP http://purl.obolibrary.org/obo/GO_0006201 GO:0006202 biolink:BiologicalProcess GMP catabolic process to guanine The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine. go.json GMP breakdown to guanine|GMP degradation to guanine http://purl.obolibrary.org/obo/GO_0006202 GO:0006200 biolink:BiologicalProcess obsolete ATP catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. Wikipedia:ATP_hydrolysis go.json ATP breakdown|ATP catabolism|ATP degradation|ATP hydrolysis True http://purl.obolibrary.org/obo/GO_0006200 GO:0070899 biolink:BiologicalProcess mitochondrial tRNA wobble uridine modification The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified. go.json http://purl.obolibrary.org/obo/GO_0070899 GO:0070897 biolink:BiologicalProcess transcription preinitiation complex assembly The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides. go.json DNA-dependent transcriptional preinitiation complex assembly|DNA-templated transcriptional preinitiation complex assembly|bacterial-type RNA polymerase preinitiation complex assembly|bacterial-type RNA polymerase transcription PIC formation|bacterial-type RNA polymerase transcriptional preinitiation complex formation|transcription PIC biosynthesis|transcription PIC formation|transcriptional preinitiation complex formation http://purl.obolibrary.org/obo/GO_0070897 GO:0021842 biolink:BiologicalProcess chemorepulsion involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex. go.json negative chemotaxis involved in interneuron migration from the subpallium to the cortex http://purl.obolibrary.org/obo/GO_0021842 GO:0070898 biolink:BiologicalProcess RNA polymerase III preinitiation complex assembly The formation of a large multiprotein-DNA complex that self-assembles on a tRNA gene through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC), (which includes BDP1, BRF1, TBP, TFIIIC in human). The PIC engages RNA polymerase III on its DNA template strand and sparks polymerization of the first few RNA nucleotides. go.json RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly|RNA polymerase III transcription PIC biosynthesis|RNA polymerase III transcription PIC formation|RNA polymerase III transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex formation|RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly|RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly|RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly http://purl.obolibrary.org/obo/GO_0070898 GO:0021843 biolink:BiologicalProcess substrate-independent telencephalic tangential interneuron migration The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. go.json http://purl.obolibrary.org/obo/GO_0021843 GO:0021844 biolink:BiologicalProcess interneuron sorting involved in substrate-independent cerebral cortex tangential migration The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures. go.json http://purl.obolibrary.org/obo/GO_0021844 GO:0070895 biolink:BiologicalProcess obsolete negative regulation of transposon integration OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. go.json down regulation of transposon integration|down-regulation of transposon integration|downregulation of transposon integration|inhibition of transposon integration True http://purl.obolibrary.org/obo/GO_0070895 GO:0021845 biolink:BiologicalProcess neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner. go.json http://purl.obolibrary.org/obo/GO_0021845 GO:0070896 biolink:BiologicalProcess obsolete positive regulation of transposon integration OBSOLETE. Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. go.json activation of transposon integration|stimulation of transposon integration|up regulation of transposon integration|up-regulation of transposon integration|upregulation of transposon integration True http://purl.obolibrary.org/obo/GO_0070896 GO:0070893 biolink:BiologicalProcess obsolete transposon integration OBSOLETE. Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome. go.json True http://purl.obolibrary.org/obo/GO_0070893 GO:0021846 biolink:BiologicalProcess cell proliferation in forebrain The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. go.json http://purl.obolibrary.org/obo/GO_0021846 GO:0070894 biolink:BiologicalProcess obsolete regulation of transposon integration OBSOLETE. Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0070894 GO:0021847 biolink:BiologicalProcess ventricular zone neuroblast division The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially. go.json neuroblast division in ventricular zone http://purl.obolibrary.org/obo/GO_0021847 GO:0021848 biolink:BiologicalProcess neuroblast division in subpallium The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially. go.json neuroblast division in the ventral telencephalon http://purl.obolibrary.org/obo/GO_0021848 GO:0070891 biolink:MolecularActivity lipoteichoic acid binding Binding to lipoteichoic acid. go.json http://purl.obolibrary.org/obo/GO_0070891 GO:0021849 biolink:BiologicalProcess neuroblast division in subventricular zone The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially. go.json http://purl.obolibrary.org/obo/GO_0021849 GO:0070892 biolink:MolecularActivity lipoteichoic acid immune receptor activity Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response. go.json lipoteichoic acid receptor activity http://purl.obolibrary.org/obo/GO_0070892 GO:0006218 biolink:BiologicalProcess uridine catabolic process The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. go.json uridine breakdown|uridine catabolism|uridine degradation http://purl.obolibrary.org/obo/GO_0006218 GO:0006219 biolink:BiologicalProcess deoxyuridine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. go.json deoxyuridine breakdown|deoxyuridine catabolism|deoxyuridine degradation http://purl.obolibrary.org/obo/GO_0006219 GO:0006216 biolink:BiologicalProcess cytidine catabolic process The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside. go.json cytidine breakdown|cytidine catabolism|cytidine degradation http://purl.obolibrary.org/obo/GO_0006216 GO:0006217 biolink:BiologicalProcess deoxycytidine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. go.json deoxycytidine breakdown|deoxycytidine catabolism|deoxycytidine degradation http://purl.obolibrary.org/obo/GO_0006217 GO:0006214 biolink:BiologicalProcess thymidine catabolic process The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. go.json deoxyribosylthymine catabolic process|deoxyribosylthymine catabolism|thymidine breakdown|thymidine catabolism|thymidine degradation http://purl.obolibrary.org/obo/GO_0006214 GO:0006215 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006215 GO:0021830 biolink:BiologicalProcess interneuron migration from the subpallium to the cortex The directed movement of interneurons from the subpallium to the cortex during forebrain development. go.json http://purl.obolibrary.org/obo/GO_0021830 GO:0006212 biolink:BiologicalProcess uracil catabolic process The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. go.json uracil breakdown|uracil catabolism|uracil degradation http://purl.obolibrary.org/obo/GO_0006212 GO:0006213 biolink:BiologicalProcess pyrimidine nucleoside metabolic process The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json pyrimidine metabolic process|pyrimidine metabolism|pyrimidine nucleoside metabolism http://purl.obolibrary.org/obo/GO_0006213 GO:0006210 biolink:BiologicalProcess thymine catabolic process The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. go.json thymine breakdown|thymine catabolism|thymine degradation http://purl.obolibrary.org/obo/GO_0006210 GO:0006211 biolink:BiologicalProcess 5-methylcytosine catabolic process The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA. go.json 5-methylcytosine breakdown|5-methylcytosine catabolism|5-methylcytosine degradation http://purl.obolibrary.org/obo/GO_0006211 GO:0021839 biolink:BiologicalProcess interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex. go.json http://purl.obolibrary.org/obo/GO_0021839 GO:0070888 biolink:MolecularActivity E-box binding Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. go.json E-box promoter binding http://purl.obolibrary.org/obo/GO_0070888 GO:0070889 biolink:BiologicalProcess platelet alpha granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets. go.json platelet alpha granule organisation|platelet alpha granule organization and biogenesis|platelet alpha-granule organization http://purl.obolibrary.org/obo/GO_0070889 GO:0021831 biolink:BiologicalProcess embryonic olfactory bulb interneuron precursor migration The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb. go.json http://purl.obolibrary.org/obo/GO_0021831 GO:0070886 biolink:BiologicalProcess positive regulation of calcineurin-NFAT signaling cascade Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. go.json activation of calcineurin-NFAT signaling cascade|positive regulation of NFAT protein import into nucleus|positive regulation of calcineurin-NFAT signaling pathway|positive regulation of calcineurin-NFAT signalling cascade|stimulation of calcineurin-NFAT signaling cascade|up regulation of calcineurin-NFAT signaling cascade|up-regulation of calcineurin-NFAT signaling cascade|upregulation of calcineurin-NFAT signaling cascade http://purl.obolibrary.org/obo/GO_0070886 GO:0021832 biolink:BiologicalProcess cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration. go.json http://purl.obolibrary.org/obo/GO_0021832 GO:0070887 biolink:BiologicalProcess cellular response to chemical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. go.json http://purl.obolibrary.org/obo/GO_0070887 gocheck_do_not_manually_annotate GO:0070884 biolink:BiologicalProcess regulation of calcineurin-NFAT signaling cascade Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. go.json NFAT protein import into nucleus|regulation of NFAT protein import into nucleus|regulation of calcineurin-NFAT signaling pathway|regulation of calcineurin-NFAT signalling cascade http://purl.obolibrary.org/obo/GO_0070884 GO:0021833 biolink:BiologicalProcess cell-matrix adhesion involved in tangential migration using cell-cell interactions The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021833 GO:0021834 biolink:BiologicalProcess chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb. go.json negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration http://purl.obolibrary.org/obo/GO_0021834 GO:0070885 biolink:BiologicalProcess negative regulation of calcineurin-NFAT signaling cascade Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. go.json down regulation of calcineurin-NFAT signaling cascade|down-regulation of calcineurin-NFAT signaling cascade|downregulation of calcineurin-NFAT signaling cascade|inhibition of NFAT protein import into nucleus|inhibition of calcineurin-NFAT signaling cascade|negative regulation of NFAT protein import into nucleus|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of calcineurin-NFAT signalling cascade|termination of calcineurin-NFAT signaling cascade http://purl.obolibrary.org/obo/GO_0070885 GO:0021835 biolink:BiologicalProcess chemoattraction involved in embryonic olfactory bulb interneuron precursor migration The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb. go.json positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration http://purl.obolibrary.org/obo/GO_0021835 GO:0070882 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070882 GO:0070883 biolink:MolecularActivity pre-miRNA binding Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. go.json pre-microRNA binding|precursor microRNA binding http://purl.obolibrary.org/obo/GO_0070883 GO:0021836 biolink:BiologicalProcess chemorepulsion involved in postnatal olfactory bulb interneuron migration The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration. go.json negative chemotaxis involved in postnatal olfactory bulb interneuron migration http://purl.obolibrary.org/obo/GO_0021836 GO:0070880 biolink:BiologicalProcess fungal-type cell wall beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. go.json fungal-type cell wall beta-glucan anabolism|fungal-type cell wall beta-glucan biosynthesis|fungal-type cell wall beta-glucan formation|fungal-type cell wall beta-glucan synthesis http://purl.obolibrary.org/obo/GO_0070880 GO:0021837 biolink:BiologicalProcess motogenic signaling involved in postnatal olfactory bulb interneuron migration The signaling that results in the stimulation of cell movement in the rostral migratory stream. go.json motogenic signalling involved in postnatal olfactory bulb interneuron migration http://purl.obolibrary.org/obo/GO_0021837 GO:0070881 biolink:BiologicalProcess regulation of proline transport Any process that modulates the frequency, rate or extent of proline transport. go.json http://purl.obolibrary.org/obo/GO_0070881 GO:0021838 biolink:BiologicalProcess motogenic signaling involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex. go.json motogenic signalling involved in interneuron migration from the subpallium to the cortex http://purl.obolibrary.org/obo/GO_0021838 GO:0031292 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031292 GO:0045806 biolink:BiologicalProcess negative regulation of endocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. go.json down regulation of endocytosis|down-regulation of endocytosis|downregulation of endocytosis|inhibition of endocytosis http://purl.obolibrary.org/obo/GO_0045806 GO:0031293 biolink:BiologicalProcess membrane protein intracellular domain proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. go.json membrane protein solubilization http://purl.obolibrary.org/obo/GO_0031293 GO:0045807 biolink:BiologicalProcess positive regulation of endocytosis Any process that activates or increases the frequency, rate or extent of endocytosis. go.json activation of endocytosis|stimulation of endocytosis|up regulation of endocytosis|up-regulation of endocytosis|upregulation of endocytosis http://purl.obolibrary.org/obo/GO_0045807 GO:0045804 biolink:BiologicalProcess negative regulation of eclosion Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion. go.json down regulation of eclosion|down-regulation of eclosion|downregulation of eclosion|inhibition of eclosion http://purl.obolibrary.org/obo/GO_0045804 GO:0031290 biolink:BiologicalProcess retinal ganglion cell axon guidance The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. go.json retinal ganglion cell axon pathfinding http://purl.obolibrary.org/obo/GO_0031290 GO:0031291 biolink:BiologicalProcess Ran protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state. go.json http://purl.obolibrary.org/obo/GO_0031291 GO:0045805 biolink:BiologicalProcess positive regulation of eclosion Any process that activates or increases the frequency, rate or extent of eclosion. go.json activation of eclosion|stimulation of eclosion|up regulation of eclosion|up-regulation of eclosion|upregulation of eclosion http://purl.obolibrary.org/obo/GO_0045805 GO:0045802 biolink:BiologicalProcess obsolete negative regulation of cytoskeleton OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton. go.json negative regulation of cytoskeleton True http://purl.obolibrary.org/obo/GO_0045802 GO:0045803 biolink:BiologicalProcess obsolete positive regulation of cytoskeleton OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton. go.json positive regulation of cytoskeleton True http://purl.obolibrary.org/obo/GO_0045803 GO:0045800 biolink:BiologicalProcess negative regulation of chitin-based cuticle tanning Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning. go.json down regulation of cuticle tanning|down-regulation of cuticle tanning|downregulation of cuticle tanning|inhibition of cuticle tanning|negative regulation of cuticle hardening|negative regulation of cuticle tanning http://purl.obolibrary.org/obo/GO_0045800 GO:0045801 biolink:BiologicalProcess positive regulation of chitin-based cuticle tanning Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning. go.json activation of cuticle tanning|positive regulation of cuticle hardening|positive regulation of cuticle tanning|stimulation of cuticle tanning|up regulation of cuticle tanning|up-regulation of cuticle tanning|upregulation of cuticle tanning http://purl.obolibrary.org/obo/GO_0045801 GO:0031298 biolink:CellularComponent replication fork protection complex A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. go.json Swi1-Swi3 complex|TIMELESS-TIPIN complex|replisome progression complex http://purl.obolibrary.org/obo/GO_0031298 GO:0031299 biolink:MolecularActivity taurine-pyruvate aminotransferase activity Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde. EC:2.6.1.77|KEGG_REACTION:R05652|MetaCyc:TAURINE-AMINOTRANSFERASE-RXN|RHEA:10420 go.json Tpa|taurine:pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0031299 GO:0031296 biolink:BiologicalProcess B cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation. go.json B cell co-stimulation|B lymphocyte co-stimulation|B lymphocyte costimulation|B-cell co-stimulation|B-cell costimulation|B-lymphocyte co-stimulation|B-lymphocyte costimulation http://purl.obolibrary.org/obo/GO_0031296 GO:0031297 biolink:BiologicalProcess replication fork processing The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. go.json collapsed replication fork processing|recovery from replication fork arrest|recovery from replication fork arrest at rDNA locus|recovery from replication fork stalling|recovery from replication fork stalling at rDNA locus|replication fork processing at rDNA locus|replication fork processing at ribosomal DNA locus|replication fork restart|replication restart http://purl.obolibrary.org/obo/GO_0031297 GO:0031294 biolink:BiologicalProcess lymphocyte costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. go.json lymphocyte co-stimulation http://purl.obolibrary.org/obo/GO_0031294 GO:0045808 biolink:BiologicalProcess negative regulation of establishment of competence for transformation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation. go.json down regulation of establishment of competence for transformation|down-regulation of establishment of competence for transformation|downregulation of establishment of competence for transformation|inhibition of establishment of competence for transformation|inhibitor of the establishment of competence for transformation activity http://purl.obolibrary.org/obo/GO_0045808 GO:0031295 biolink:BiologicalProcess T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. go.json T cell co-stimulation|T lymphocyte costimulation|T-cell co-stimulation|T-cell costimulation|T-lymphocyte costimulation http://purl.obolibrary.org/obo/GO_0031295 GO:0045809 biolink:BiologicalProcess positive regulation of establishment of competence for transformation Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation. go.json activation of establishment of competence for transformation|activator of the establishment of competence for transformation activity|stimulation of establishment of competence for transformation|up regulation of establishment of competence for transformation|up-regulation of establishment of competence for transformation|upregulation of establishment of competence for transformation http://purl.obolibrary.org/obo/GO_0045809 GO:0045810 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045810 GO:0031281 biolink:BiologicalProcess positive regulation of cyclase activity Any process that activates or increases the activity of a cyclase. go.json activation of cyclase activity|stimulation of cyclase activity|up regulation of cyclase activity|up-regulation of cyclase activity|upregulation of cyclase activity http://purl.obolibrary.org/obo/GO_0031281 gocheck_do_not_annotate GO:0045817 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045817 GO:0045818 biolink:BiologicalProcess negative regulation of glycogen catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. go.json down regulation of glycogen catabolic process|down-regulation of glycogen catabolic process|downregulation of glycogen catabolic process|inhibition of glycogen catabolic process|negative regulation of glycogen breakdown|negative regulation of glycogen catabolism|negative regulation of glycogen degradation|negative regulation of glycogenolysis http://purl.obolibrary.org/obo/GO_0045818 GO:0031282 biolink:BiologicalProcess regulation of guanylate cyclase activity Any process that modulates the frequency, rate or extent of guanylate cyclase activity. go.json http://purl.obolibrary.org/obo/GO_0031282 gocheck_do_not_annotate GO:0045815 biolink:BiologicalProcess transcription initiation-coupled chromatin remodeling An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. go.json DNA replication-independent chromatin organization|activation of gene expression, epigenetic|chromatin-mediated maintenance of transcription|epigenetic maintenance of chromatin in transcription-competent conformation|euchromatin assembly|euchromatin organisation|euchromatin organization|long-term maintenance of gene activation|maintenance of chromatin in transcription-competent conformation|positive regulation of gene expression, epigenetic|stimulation of gene expression, epigenetic|transciptional initiation-coupled chromatin remodeling|transciptional initiation-coupled chromatin remodelling|transcription initiation coupled chromatin remodeling|transcription initiation coupled chromatin remodelling|transcriptional initiation-coupled chromatin remodeling|transcriptional initiation-coupled chromatin remodelling|up regulation of gene expression, epigenetic|up-regulation of gene expression, epigenetic|upregulation of gene expression, epigenetic http://purl.obolibrary.org/obo/GO_0045815 GO:0031280 biolink:BiologicalProcess negative regulation of cyclase activity Any process that stops or reduces the activity of a cyclase. go.json down regulation of cyclase activity|down-regulation of cyclase activity|downregulation of cyclase activity|inhibition of cyclase activity http://purl.obolibrary.org/obo/GO_0031280 gocheck_do_not_annotate GO:0045816 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045816 GO:0045813 biolink:BiologicalProcess positive regulation of Wnt signaling pathway, calcium modulating pathway Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). go.json activation of frizzled-2 signaling pathway|positive regulation of Wnt receptor signaling pathway, calcium modulating pathway|positive regulation of Wnt-activated signaling pathway, calcium modulating pathway|positive regulation of frizzled-2 signaling pathway|positive regulation of frizzled-2 signalling pathway|stimulation of frizzled-2 signaling pathway|up regulation of frizzled-2 signaling pathway|up-regulation of frizzled-2 signaling pathway|upregulation of frizzled-2 signaling pathway http://purl.obolibrary.org/obo/GO_0045813 GO:0045814 biolink:BiologicalProcess negative regulation of gene expression, epigenetic An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. go.json down regulation of gene expression, epigenetic|down-regulation of gene expression, epigenetic|downregulation of gene expression, epigenetic|gene silencing|inhibition of gene expression, epigenetic http://purl.obolibrary.org/obo/GO_0045814 GO:0045811 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045811 GO:0045812 biolink:BiologicalProcess negative regulation of Wnt signaling pathway, calcium modulating pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). go.json down regulation of frizzled-2 signaling pathway|down-regulation of frizzled-2 signaling pathway|downregulation of frizzled-2 signaling pathway|inhibition of frizzled-2 signaling pathway|negative regulation of Wnt receptor signaling pathway, calcium modulating pathway|negative regulation of Wnt-activated signaling pathway, calcium modulating pathway|negative regulation of frizzled-2 signaling pathway|negative regulation of frizzled-2 signalling pathway http://purl.obolibrary.org/obo/GO_0045812 GO:0031289 biolink:BiologicalProcess actin phosphorylation The transfer of one or more phosphate groups to an actin molecule. go.json http://purl.obolibrary.org/obo/GO_0031289 gocheck_do_not_annotate GO:0031287 biolink:BiologicalProcess positive regulation of sorocarp stalk cell differentiation Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. go.json activation of stalk cell differentiation|positive regulation of stalk cell differentiation|stimulation of stalk cell differentiation|up regulation of stalk cell differentiation|up-regulation of stalk cell differentiation|upregulation of stalk cell differentiation http://purl.obolibrary.org/obo/GO_0031287 GO:0031288 biolink:BiologicalProcess sorocarp morphogenesis The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum. go.json fruiting body morphogenesis http://purl.obolibrary.org/obo/GO_0031288 GO:0031285 biolink:BiologicalProcess regulation of sorocarp stalk cell differentiation Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. go.json regulation of stalk cell differentiation http://purl.obolibrary.org/obo/GO_0031285 GO:0031286 biolink:BiologicalProcess negative regulation of sorocarp stalk cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. go.json down regulation of stalk cell differentiation|down-regulation of stalk cell differentiation|downregulation of stalk cell differentiation|inhibition of stalk cell differentiation|negative regulation of stalk cell differentiation http://purl.obolibrary.org/obo/GO_0031286 GO:0031283 biolink:BiologicalProcess negative regulation of guanylate cyclase activity Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity. go.json down regulation of guanylate cyclase activity|down-regulation of guanylate cyclase activity|downregulation of guanylate cyclase activity|inhibition of guanylate cyclase activity http://purl.obolibrary.org/obo/GO_0031283 gocheck_do_not_annotate GO:0045819 biolink:BiologicalProcess positive regulation of glycogen catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. go.json activation of glycogen catabolic process|positive regulation of glycogen breakdown|positive regulation of glycogen catabolism|positive regulation of glycogen degradation|positive regulation of glycogenolysis|stimulation of glycogen catabolic process|up regulation of glycogen catabolic process|up-regulation of glycogen catabolic process|upregulation of glycogen catabolic process http://purl.obolibrary.org/obo/GO_0045819 GO:0031284 biolink:BiologicalProcess positive regulation of guanylate cyclase activity Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. go.json activation of guanylate cyclase activity|stimulation of guanylate cyclase activity|up regulation of guanylate cyclase activity|up-regulation of guanylate cyclase activity|upregulation of guanylate cyclase activity http://purl.obolibrary.org/obo/GO_0031284 gocheck_do_not_annotate GO:0045820 biolink:BiologicalProcess negative regulation of glycolytic process Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. go.json down regulation of glycolysis|down-regulation of glycolysis|downregulation of glycolysis|inhibition of glycolysis http://purl.obolibrary.org/obo/GO_0045820 GO:0045821 biolink:BiologicalProcess positive regulation of glycolytic process Any process that activates or increases the frequency, rate or extent of glycolysis. go.json activation of glycolysis|stimulation of glycolysis|up regulation of glycolysis|up-regulation of glycolysis|upregulation of glycolysis http://purl.obolibrary.org/obo/GO_0045821 GO:0045828 biolink:BiologicalProcess positive regulation of isoprenoid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. go.json activation of isoprenoid metabolic process|positive regulation of isoprenoid metabolism|stimulation of isoprenoid metabolic process|up regulation of isoprenoid metabolic process|up-regulation of isoprenoid metabolic process|upregulation of isoprenoid metabolic process http://purl.obolibrary.org/obo/GO_0045828 GO:0031270 biolink:BiologicalProcess pseudopodium retraction The myosin-based contraction and retraction of a pseudopodium. go.json http://purl.obolibrary.org/obo/GO_0031270 GO:0045829 biolink:BiologicalProcess negative regulation of isotype switching Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching. go.json down regulation of isotype switching|down-regulation of isotype switching|downregulation of isotype switching|inhibition of isotype switching|negative regulation of class switch recombination|negative regulation of class switching|negative regulation of isotype switch recombination http://purl.obolibrary.org/obo/GO_0045829 GO:0031271 biolink:BiologicalProcess lateral pseudopodium assembly The extension of a pseudopodium from the lateral area of a cell. go.json lateral pseudopodium formation http://purl.obolibrary.org/obo/GO_0031271 GO:0045826 biolink:BiologicalProcess obsolete positive regulation of intermediate filament polymerization and/or depolymerization OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization. go.json positive regulation of intermediate filament polymerization and/or depolymerization True http://purl.obolibrary.org/obo/GO_0045826 GO:0045827 biolink:BiologicalProcess negative regulation of isoprenoid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. go.json down regulation of isoprenoid metabolic process|down-regulation of isoprenoid metabolic process|downregulation of isoprenoid metabolic process|inhibition of isoprenoid metabolic process|negative regulation of isoprenoid metabolism http://purl.obolibrary.org/obo/GO_0045827 GO:0045824 biolink:BiologicalProcess negative regulation of innate immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. go.json down regulation of innate immune response|down-regulation of innate immune response|downregulation of innate immune response|inhibition of innate immune response http://purl.obolibrary.org/obo/GO_0045824 GO:0045825 biolink:BiologicalProcess obsolete negative regulation of intermediate filament polymerization and/or depolymerization OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization. go.json negative regulation of intermediate filament polymerization and/or depolymerization True http://purl.obolibrary.org/obo/GO_0045825 GO:0045822 biolink:BiologicalProcess negative regulation of heart contraction Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. go.json down regulation of heart contraction|down-regulation of heart contraction|downregulation of heart contraction|inhibition of heart contraction|negative regulation of cardiac contraction http://purl.obolibrary.org/obo/GO_0045822 GO:0045823 biolink:BiologicalProcess positive regulation of heart contraction Any process that activates or increases the frequency, rate or extent of heart contraction. go.json activation of heart contraction|positive regulation of cardiac contraction|stimulation of heart contraction|up regulation of heart contraction|up-regulation of heart contraction|upregulation of heart contraction http://purl.obolibrary.org/obo/GO_0045823 GO:0031278 biolink:MolecularActivity alpha-1,2-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage. go.json http://purl.obolibrary.org/obo/GO_0031278 GO:0031279 biolink:BiologicalProcess regulation of cyclase activity Any process that modulates the frequency, rate or extent of cyclase activity. go.json http://purl.obolibrary.org/obo/GO_0031279 gocheck_do_not_annotate GO:0031276 biolink:BiologicalProcess obsolete negative regulation of lateral pseudopodium assembly OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell. go.json down regulation of lateral pseudopodium formation|down-regulation of lateral pseudopodium formation|downregulation of lateral pseudopodium formation|inhibition of lateral pseudopodium formation|negative regulation of lateral pseudopodium formation True http://purl.obolibrary.org/obo/GO_0031276 GO:0031277 biolink:BiologicalProcess obsolete positive regulation of lateral pseudopodium assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell. go.json activation of lateral pseudopodium formation|positive regulation of lateral pseudopodium formation|stimulation of lateral pseudopodium formation|up regulation of lateral pseudopodium formation|up-regulation of lateral pseudopodium formation|upregulation of lateral pseudopodium formation True http://purl.obolibrary.org/obo/GO_0031277 GO:0031274 biolink:BiologicalProcess positive regulation of pseudopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. go.json activation of pseudopodium formation|positive regulation of pseudopodium formation|stimulation of pseudopodium formation|up regulation of pseudopodium formation|up-regulation of pseudopodium formation|upregulation of pseudopodium formation http://purl.obolibrary.org/obo/GO_0031274 GO:0031275 biolink:BiologicalProcess obsolete regulation of lateral pseudopodium assembly OBSOLETE. Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell. go.json regulation of lateral pseudopodium formation True http://purl.obolibrary.org/obo/GO_0031275 GO:0031272 biolink:BiologicalProcess regulation of pseudopodium assembly Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. go.json regulation of pseudopodium formation http://purl.obolibrary.org/obo/GO_0031272 GO:0031273 biolink:BiologicalProcess negative regulation of pseudopodium assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia. go.json down regulation of pseudopodium formation|down-regulation of pseudopodium formation|downregulation of pseudopodium formation|inhibition of pseudopodium formation|negative regulation of pseudopodium formation http://purl.obolibrary.org/obo/GO_0031273 GO:0031269 biolink:BiologicalProcess pseudopodium assembly The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. go.json pseudopodium extension|pseudopodium formation http://purl.obolibrary.org/obo/GO_0031269 GO:0045831 biolink:BiologicalProcess negative regulation of light-activated channel activity Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity. go.json down regulation of light-activated channel activity|down-regulation of light-activated channel activity|downregulation of light-activated channel activity|inhibition of light-activated channel activity http://purl.obolibrary.org/obo/GO_0045831 gocheck_do_not_annotate GO:0045832 biolink:BiologicalProcess positive regulation of light-activated channel activity Any process that activates or increases the frequency, rate or extent of light-activated channel activity. go.json activation of light-activated channel activity|stimulation of light-activated channel activity|up regulation of light-activated channel activity|up-regulation of light-activated channel activity|upregulation of light-activated channel activity http://purl.obolibrary.org/obo/GO_0045832 gocheck_do_not_annotate GO:0045830 biolink:BiologicalProcess positive regulation of isotype switching Any process that activates or increases the frequency, rate or extent of isotype switching. go.json activation of isotype switching|positive regulation of class switch recombination|positive regulation of class switching|positive regulation of isotype switch recombination|stimulation of isotype switching|up regulation of isotype switching|up-regulation of isotype switching|upregulation of isotype switching http://purl.obolibrary.org/obo/GO_0045830 GO:0045839 biolink:BiologicalProcess negative regulation of mitotic nuclear division Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. go.json down regulation of mitosis|down-regulation of mitosis|downregulation of mitosis|inhibition of mitosis|negative regulation of mitosis http://purl.obolibrary.org/obo/GO_0045839 GO:0031260 biolink:CellularComponent pseudopodium membrane The portion of the plasma membrane surrounding a pseudopodium. go.json http://purl.obolibrary.org/obo/GO_0031260 GO:0045837 biolink:BiologicalProcess negative regulation of membrane potential Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json down regulation of membrane potential|down-regulation of membrane potential|downregulation of membrane potential|inhibition of membrane potential|reduction of membrane potential http://purl.obolibrary.org/obo/GO_0045837 GO:0045838 biolink:BiologicalProcess positive regulation of membrane potential Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json activation of membrane potential|elevation of membrane potential|stimulation of membrane potential|up regulation of membrane potential|up-regulation of membrane potential|upregulation of membrane potential http://purl.obolibrary.org/obo/GO_0045838 GO:0045835 biolink:BiologicalProcess negative regulation of meiotic nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. go.json down regulation of meiosis|down-regulation of meiosis|downregulation of meiosis|inhibition of meiosis|negative regulation of meiosis http://purl.obolibrary.org/obo/GO_0045835 GO:0045836 biolink:BiologicalProcess positive regulation of meiotic nuclear division Any process that activates or increases the frequency, rate or extent of meiosis. go.json activation of meiosis|positive regulation of meiosis|stimulation of meiosis|up regulation of meiosis|up-regulation of meiosis|upregulation of meiosis http://purl.obolibrary.org/obo/GO_0045836 GO:0045833 biolink:BiologicalProcess negative regulation of lipid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. go.json down regulation of lipid metabolic process|down-regulation of lipid metabolic process|downregulation of lipid metabolic process|inhibition of lipid metabolic process|negative regulation of lipid metabolism http://purl.obolibrary.org/obo/GO_0045833 GO:0045834 biolink:BiologicalProcess positive regulation of lipid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. go.json activation of lipid metabolic process|positive regulation of lipid metabolism|stimulation of lipid metabolic process|up regulation of lipid metabolic process|up-regulation of lipid metabolic process|upregulation of lipid metabolic process http://purl.obolibrary.org/obo/GO_0045834 GO:0031267 biolink:MolecularActivity small GTPase binding Binding to a small monomeric GTPase. go.json ADP-ribosylation factor binding|ARF binding|GTP-Ral binding|GTP-Rho binding|REP|Rab GTPase binding|Rab escort protein activity|Rab interactor activity|Rac GTPase binding|Ral GTPase binding|Ran GTPase binding|Ran protein binding|Ran-binding protein|Ras GTPase binding|Ras interactor activity|Rho GTPase binding http://purl.obolibrary.org/obo/GO_0031267 GO:0031268 biolink:BiologicalProcess pseudopodium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. go.json pseudopodium organisation|pseudopodium organization and biogenesis http://purl.obolibrary.org/obo/GO_0031268 GO:0031265 biolink:CellularComponent CD95 death-inducing signaling complex A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor. go.json CD95 DISC|CD95 death-inducing signalling complex|Fas death-inducing signaling complex http://purl.obolibrary.org/obo/GO_0031265 GO:0031266 biolink:CellularComponent TRAIL death-inducing signaling complex A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor. go.json TRAIL DISC|TRAIL death-inducing signalling complex http://purl.obolibrary.org/obo/GO_0031266 GO:0031263 biolink:MolecularActivity obsolete ATPase-coupled amine transporter activity OBSOLETE. Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in). go.json ATP-dependent amine transporter activity|amine ABC transporter|amine-transporting ATPase activity True http://purl.obolibrary.org/obo/GO_0031263 GO:0031264 biolink:CellularComponent death-inducing signaling complex A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. Wikipedia:Death-inducing_signaling_complex go.json DISC|DISC protein complex|death receptor-induced signaling complex|death receptor-induced signalling complex|death-inducing signalling complex http://purl.obolibrary.org/obo/GO_0031264 goslim_pir GO:0031261 biolink:CellularComponent DNA replication preinitiation complex A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. go.json pre-IC http://purl.obolibrary.org/obo/GO_0031261 GO:0031262 biolink:CellularComponent Ndc80 complex An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis. go.json Nuf2-Ndc80 complex http://purl.obolibrary.org/obo/GO_0031262 GO:0031258 biolink:CellularComponent lamellipodium membrane The portion of the plasma membrane surrounding a lamellipodium. go.json http://purl.obolibrary.org/obo/GO_0031258 GO:0031259 biolink:CellularComponent uropod membrane The portion of the plasma membrane surrounding a uropod. go.json uropodium membrane http://purl.obolibrary.org/obo/GO_0031259 GO:0045842 biolink:BiologicalProcess positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. go.json activation of mitotic metaphase/anaphase transition|stimulation of mitotic metaphase/anaphase transition|up regulation of mitotic metaphase/anaphase transition|up-regulation of mitotic metaphase/anaphase transition|upregulation of mitotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_0045842 GO:0045843 biolink:BiologicalProcess negative regulation of striated muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. go.json down regulation of striated muscle development|down-regulation of striated muscle development|downregulation of striated muscle development|inhibition of striated muscle development http://purl.obolibrary.org/obo/GO_0045843 GO:0045840 biolink:BiologicalProcess positive regulation of mitotic nuclear division Any process that activates or increases the frequency, rate or extent of mitosis. go.json activation of mitosis|mitogenic activity|positive regulation of mitosis|stimulation of mitosis|up regulation of mitosis|up-regulation of mitosis|upregulation of mitosis http://purl.obolibrary.org/obo/GO_0045840 GO:0045841 biolink:BiologicalProcess negative regulation of mitotic metaphase/anaphase transition Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. go.json down regulation of mitotic metaphase/anaphase transition|down-regulation of mitotic metaphase/anaphase transition|downregulation of mitotic metaphase/anaphase transition|inhibition of mitotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_0045841 GO:0045848 biolink:BiologicalProcess positive regulation of nitrogen utilization Any process that activates or increases the frequency, rate or extent of nitrogen utilization. go.json activation of nitrogen utilization|stimulation of nitrogen utilization|up regulation of nitrogen utilization|up-regulation of nitrogen utilization|upregulation of nitrogen utilization http://purl.obolibrary.org/obo/GO_0045848 GO:0045849 biolink:BiologicalProcess negative regulation of nurse cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process. go.json down regulation of nurse cell apoptosis|down-regulation of nurse cell apoptosis|downregulation of nurse cell apoptosis|inhibition of nurse cell apoptosis|negative regulation of nurse cell apoptosis http://purl.obolibrary.org/obo/GO_0045849 GO:0045846 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045846 GO:0045847 biolink:BiologicalProcess negative regulation of nitrogen utilization Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization. go.json down regulation of nitrogen utilization|down-regulation of nitrogen utilization|downregulation of nitrogen utilization|inhibition of nitrogen utilization http://purl.obolibrary.org/obo/GO_0045847 GO:0045844 biolink:BiologicalProcess positive regulation of striated muscle tissue development Any process that activates or increases the frequency, rate or extent of striated muscle development. go.json activation of striated muscle development|stimulation of striated muscle development|up regulation of striated muscle development|up-regulation of striated muscle development|upregulation of striated muscle development http://purl.obolibrary.org/obo/GO_0045844 GO:0045845 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045845 GO:0031256 biolink:CellularComponent leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell. go.json http://purl.obolibrary.org/obo/GO_0031256 GO:0031257 biolink:CellularComponent cell trailing edge membrane The portion of the plasma membrane surrounding the trailing edge of a motile cell. go.json trailing edge membrane http://purl.obolibrary.org/obo/GO_0031257 GO:0031254 biolink:CellularComponent cell trailing edge The area of a motile cell opposite to the direction of movement. go.json back of cell|trailing edge http://purl.obolibrary.org/obo/GO_0031254 goslim_pir GO:0031255 biolink:CellularComponent lateral part of motile cell The area of a motile cell perpendicular to the direction of movement. go.json http://purl.obolibrary.org/obo/GO_0031255 GO:0031252 biolink:CellularComponent cell leading edge The area of a motile cell closest to the direction of movement. go.json front of cell|leading edge of cell http://purl.obolibrary.org/obo/GO_0031252 goslim_pir GO:0031253 biolink:CellularComponent cell projection membrane The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. go.json membrane extension|membrane projection http://purl.obolibrary.org/obo/GO_0031253 GO:0031250 biolink:CellularComponent anaerobic ribonucleoside-triphosphate reductase complex An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit. go.json http://purl.obolibrary.org/obo/GO_0031250 GO:0031251 biolink:CellularComponent PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. go.json poly(A) nuclease complex http://purl.obolibrary.org/obo/GO_0031251 GO:0031249 biolink:MolecularActivity denatured protein binding Binding to a denatured protein. go.json http://purl.obolibrary.org/obo/GO_0031249 GO:0031247 biolink:BiologicalProcess actin rod assembly The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules. go.json actin rod formation http://purl.obolibrary.org/obo/GO_0031247 GO:0031248 biolink:CellularComponent protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0031248 goslim_pir GO:0045853 biolink:BiologicalProcess negative regulation of bicoid mRNA localization Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. go.json down regulation of bicoid mRNA localization|down-regulation of bicoid mRNA localization|downregulation of bicoid mRNA localization|inhibition of bicoid mRNA localization|negative regulation of bicoid mRNA localisation http://purl.obolibrary.org/obo/GO_0045853 GO:0006289 biolink:BiologicalProcess nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). go.json NER|intrastrand cross-link repair|pyrimidine-dimer repair, DNA damage excision http://purl.obolibrary.org/obo/GO_0006289 GO:0045854 biolink:BiologicalProcess positive regulation of bicoid mRNA localization Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. go.json activation of bicoid mRNA localization|positive regulation of bicoid mRNA localisation|stimulation of bicoid mRNA localization|up regulation of bicoid mRNA localization|up-regulation of bicoid mRNA localization|upregulation of bicoid mRNA localization http://purl.obolibrary.org/obo/GO_0045854 GO:0045851 biolink:BiologicalProcess pH reduction Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. go.json acidification http://purl.obolibrary.org/obo/GO_0045851 GO:0006287 biolink:BiologicalProcess base-excision repair, gap-filling Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. go.json http://purl.obolibrary.org/obo/GO_0006287 GO:0045852 biolink:BiologicalProcess pH elevation Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. go.json http://purl.obolibrary.org/obo/GO_0045852 GO:0006288 biolink:BiologicalProcess base-excision repair, DNA ligation The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair. go.json http://purl.obolibrary.org/obo/GO_0006288 GO:0006285 biolink:BiologicalProcess base-excision repair, AP site formation The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. go.json http://purl.obolibrary.org/obo/GO_0006285 GO:0045850 biolink:BiologicalProcess positive regulation of nurse cell apoptotic process Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process. go.json activation of nurse cell apoptosis|positive regulation of nurse cell apoptosis|stimulation of nurse cell apoptosis|up regulation of nurse cell apoptosis|up-regulation of nurse cell apoptosis|upregulation of nurse cell apoptosis http://purl.obolibrary.org/obo/GO_0045850 GO:0006286 biolink:BiologicalProcess obsolete base-excision repair, base-free sugar-phosphate removal OBSOLETE. Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme. go.json True http://purl.obolibrary.org/obo/GO_0006286 GO:0006283 biolink:BiologicalProcess transcription-coupled nucleotide-excision repair The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. go.json TC-NER|TCR|transcription-coupled NER|transcription-coupled repair http://purl.obolibrary.org/obo/GO_0006283 GO:0070808 biolink:BiologicalProcess regulation of Hulle cell development Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. go.json http://purl.obolibrary.org/obo/GO_0070808 GO:0070809 biolink:BiologicalProcess negative regulation of Hulle cell development Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. go.json http://purl.obolibrary.org/obo/GO_0070809 GO:0006284 biolink:BiologicalProcess base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Wikipedia:Base_excision_repair go.json BER http://purl.obolibrary.org/obo/GO_0006284 GO:0070817 biolink:BiologicalProcess P-TEFb-cap methyltransferase complex localization Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location. go.json P-TEFb-cap methyltransferase complex localisation|establishment and maintenance of P-TEFb-cap methyltransferase complex localization http://purl.obolibrary.org/obo/GO_0070817 GO:0006292 biolink:BiologicalProcess obsolete pyrimidine-dimer repair, DNA damage recognition OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers. go.json pyrimidine-dimer repair, DNA damage recognition True http://purl.obolibrary.org/obo/GO_0006292 GO:0070818 biolink:MolecularActivity protoporphyrinogen oxidase activity Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor. go.json protoporphyrinogen IX oxidase activity|protoporphyrinogen-IX oxidase activity|protoporphyrinogenase activity http://purl.obolibrary.org/obo/GO_0070818 GO:0006293 biolink:BiologicalProcess nucleotide-excision repair, preincision complex stabilization The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. go.json http://purl.obolibrary.org/obo/GO_0006293 GO:0070815 biolink:MolecularActivity peptidyl-lysine 5-dioxygenase activity Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2. Reactome:R-HSA-9630022 go.json lysine hydroxylase activity|lysine,2-oxoglutarate 5-dioxygenase activity|lysine-2-oxoglutarate dioxygenase activity|lysyl hydroxylase activity|peptide-lysine 5-dioxygenase activity|peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity|peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity|protein lysine hydroxylase activity http://purl.obolibrary.org/obo/GO_0070815 GO:0045859 biolink:BiologicalProcess regulation of protein kinase activity Any process that modulates the frequency, rate or extent of protein kinase activity. go.json http://purl.obolibrary.org/obo/GO_0045859 gocheck_do_not_annotate GO:0006290 biolink:BiologicalProcess pyrimidine dimer repair The repair of UV-induced T-T, C-T and C-C dimers. go.json http://purl.obolibrary.org/obo/GO_0006290 GO:0070816 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. go.json CTD domain phosphorylation of RNA polymerase II|generation of II(0) form of RNA polymerase II|generation of hyperphosphorylated CTD of RNA polymerase II|hyperphosphorylation of RNA polymerase II C-terminal domain True http://purl.obolibrary.org/obo/GO_0070816 GO:0006291 biolink:BiologicalProcess obsolete pyrimidine-dimer repair, DNA damage excision OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme. go.json pyrimidine-dimer repair, DNA damage excision True http://purl.obolibrary.org/obo/GO_0006291 GO:0045857 biolink:BiologicalProcess obsolete negative regulation of molecular function, epigenetic OBSOLETE. Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. go.json down regulation of protein activity, epigenetic|down-regulation of protein activity, epigenetic|downregulation of protein activity, epigenetic|inhibition of protein activity, epigenetic|negative regulation of protein activity, epigenetic True http://purl.obolibrary.org/obo/GO_0045857 GO:0070813 biolink:BiologicalProcess hydrogen sulfide metabolic process The chemical reactions and pathways involving hydrogen sulfide, H2S. go.json hydrogen sulfide metabolism|hydrogen sulphide metabolic process|hydrogen sulphide metabolism http://purl.obolibrary.org/obo/GO_0070813 GO:0070814 biolink:BiologicalProcess hydrogen sulfide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. go.json hydrogen sulfide anabolism|hydrogen sulfide biosynthesis|hydrogen sulfide formation|hydrogen sulfide synthesis|hydrogen sulphide biosynthesis|hydrogen sulphide biosynthetic process http://purl.obolibrary.org/obo/GO_0070814 GO:0045858 biolink:BiologicalProcess obsolete positive regulation of molecular function, epigenetic OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. go.json activation of protein activity, epigenetic|positive regulation of protein activity, epigenetic|stimulation of protein activity, epigenetic|up regulation of protein activity, epigenetic|up-regulation of protein activity, epigenetic|upregulation of protein activity, epigenetic True http://purl.obolibrary.org/obo/GO_0045858 GO:0070811 biolink:BiologicalProcess glycerol-2-phosphate transmembrane transport The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol. go.json glycerol-2-phosphate transport http://purl.obolibrary.org/obo/GO_0070811 GO:0045855 biolink:BiologicalProcess negative regulation of pole plasm oskar mRNA localization Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. go.json down regulation of pole plasm oskar mRNA localization|down-regulation of pole plasm oskar mRNA localization|downregulation of pole plasm oskar mRNA localization|inhibition of pole plasm oskar mRNA localization|negative regulation of oocyte pole plasm oskar mRNA localization|negative regulation of pole plasm oskar mRNA localisation http://purl.obolibrary.org/obo/GO_0045855 GO:0045856 biolink:BiologicalProcess positive regulation of pole plasm oskar mRNA localization Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. go.json activation of pole plasm oskar mRNA localization|positive regulation of oocyte pole plasm oskar mRNA localization|positive regulation of pole plasm oskar mRNA localisation|stimulation of pole plasm oskar mRNA localization|up regulation of pole plasm oskar mRNA localization|up-regulation of pole plasm oskar mRNA localization|upregulation of pole plasm oskar mRNA localization http://purl.obolibrary.org/obo/GO_0045856 GO:0070812 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070812 GO:0031245 biolink:CellularComponent extrinsic component of periplasmic side of cell outer membrane The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region. go.json extrinsic to internal leaflet of cell outer membrane|extrinsic to internal side of cell outer membrane|extrinsic to internal side of outer membrane|extrinsic to periplasmic side of cell outer membrane http://purl.obolibrary.org/obo/GO_0031245 GO:0031246 biolink:CellularComponent obsolete intrinsic component of periplasmic side of cell outer membrane OBSOLETE. The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor. go.json intrinsic to external side of cell outer membrane|intrinsic to internal leaflet of cell outer membrane|intrinsic to internal side of cell outer membrane|intrinsic to internal side of outer membrane True http://purl.obolibrary.org/obo/GO_0031246 GO:0070810 biolink:BiologicalProcess positive regulation of Hulle cell development Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. go.json http://purl.obolibrary.org/obo/GO_0070810 GO:0031243 biolink:CellularComponent obsolete intrinsic component of external side of cell outer membrane OBSOLETE. The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor. go.json intrinsic to external leaflet of cell outer membrane|intrinsic to external side of cell outer membrane|intrinsic to external side of outer membrane True http://purl.obolibrary.org/obo/GO_0031243 GO:0031244 biolink:CellularComponent extrinsic component of cell outer membrane The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to cell outer membrane http://purl.obolibrary.org/obo/GO_0031244 GO:0031241 biolink:CellularComponent periplasmic side of cell outer membrane The side (leaflet) of the outer membrane that faces the periplasm of the cell. go.json internal leaflet of cell outer membrane|internal side of cell outer membrane|internal side of outer membrane http://purl.obolibrary.org/obo/GO_0031241 GO:0031242 biolink:CellularComponent extrinsic component of external side of cell outer membrane The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. go.json extrinsic to external leaflet of cell outer membrane|extrinsic to external side of cell outer membrane|extrinsic to external side of outer membrane http://purl.obolibrary.org/obo/GO_0031242 GO:0031240 biolink:CellularComponent external side of cell outer membrane The side of the outer membrane that is opposite to the side that faces the periplasm of the cell. go.json external leaflet of cell outer membrane|external side of outer membrane http://purl.obolibrary.org/obo/GO_0031240 GO:0031238 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031238 GO:0031239 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031239 GO:0031236 biolink:CellularComponent extrinsic component of periplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region. go.json extrinsic to external leaflet of plasma membrane, in periplasmic space|extrinsic to external side of plasma membrane, in periplasmic space http://purl.obolibrary.org/obo/GO_0031236 GO:0031237 biolink:CellularComponent obsolete intrinsic component of periplasmic side of plasma membrane OBSOLETE. The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. go.json intrinsic to external leaflet of plasma membrane, in periplasmic space|intrinsic to periplasmic side of plasma membrane True http://purl.obolibrary.org/obo/GO_0031237 GO:0045864 biolink:BiologicalProcess positive regulation of pteridine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine. go.json activation of pteridine metabolic process|positive regulation of pteridine metabolism|stimulation of pteridine metabolic process|up regulation of pteridine metabolic process|up-regulation of pteridine metabolic process|upregulation of pteridine metabolic process http://purl.obolibrary.org/obo/GO_0045864 GO:0045865 biolink:BiologicalProcess obsolete regulation of recombination within rDNA repeats OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. go.json regulation of recombination within rDNA repeats True http://purl.obolibrary.org/obo/GO_0045865 GO:0006298 biolink:BiologicalProcess mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. Wikipedia:DNA_mismatch_repair go.json MMR|MutS/MutL/MutH pathway|long patch mismatch repair system|mismatch repair, MutL-like pathway http://purl.obolibrary.org/obo/GO_0006298 GO:0045862 biolink:BiologicalProcess positive regulation of proteolysis Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. go.json activation of proteolysis|positive regulation of peptidolysis|stimulation of proteolysis|up regulation of proteolysis|up-regulation of proteolysis|upregulation of proteolysis http://purl.obolibrary.org/obo/GO_0045862 GO:0045863 biolink:BiologicalProcess negative regulation of pteridine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine. go.json down regulation of pteridine metabolic process|down-regulation of pteridine metabolic process|downregulation of pteridine metabolic process|inhibition of pteridine metabolic process|negative regulation of pteridine metabolism http://purl.obolibrary.org/obo/GO_0045863 GO:0006299 biolink:BiologicalProcess obsolete short patch mismatch repair system OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site. go.json short patch mismatch repair system True http://purl.obolibrary.org/obo/GO_0006299 GO:0006296 biolink:BiologicalProcess obsolete nucleotide-excision repair, DNA incision, 5'-to lesion OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage. go.json nucleotide-excision repair, DNA incision, 5' to lesion True http://purl.obolibrary.org/obo/GO_0006296 GO:0045860 biolink:BiologicalProcess positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity. go.json stimulation of protein kinase activity|up regulation of protein kinase activity|up-regulation of protein kinase activity|upregulation of protein kinase activity http://purl.obolibrary.org/obo/GO_0045860 gocheck_do_not_annotate GO:0045861 biolink:BiologicalProcess negative regulation of proteolysis Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. go.json down regulation of proteolysis|down-regulation of proteolysis|downregulation of proteolysis|inhibition of proteolysis|negative regulation of peptidolysis http://purl.obolibrary.org/obo/GO_0045861 GO:0006297 biolink:BiologicalProcess nucleotide-excision repair, DNA gap filling Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. go.json http://purl.obolibrary.org/obo/GO_0006297 GO:0006294 biolink:BiologicalProcess nucleotide-excision repair, preincision complex assembly The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. go.json nucleotide-excision repair, preincision complex formation http://purl.obolibrary.org/obo/GO_0006294 GO:0006295 biolink:BiologicalProcess obsolete nucleotide-excision repair, DNA incision, 3'-to lesion OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. go.json nucleotide-excision repair, DNA incision, 3' to lesion True http://purl.obolibrary.org/obo/GO_0006295 GO:0070806 biolink:BiologicalProcess negative regulation of phialide development Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. go.json http://purl.obolibrary.org/obo/GO_0070806 GO:0070807 biolink:BiologicalProcess positive regulation of phialide development Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. go.json http://purl.obolibrary.org/obo/GO_0070807 GO:0070804 biolink:BiologicalProcess positive regulation of metula development Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. go.json http://purl.obolibrary.org/obo/GO_0070804 GO:0070805 biolink:BiologicalProcess regulation of phialide development Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. go.json http://purl.obolibrary.org/obo/GO_0070805 GO:0070802 biolink:BiologicalProcess regulation of metula development Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. go.json http://purl.obolibrary.org/obo/GO_0070802 GO:0045868 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045868 GO:0045869 biolink:BiologicalProcess negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. go.json down regulation of retroviral genome replication|down-regulation of retroviral genome replication|downregulation of retroviral genome replication|inhibition of retroviral genome replication|negative regulation of retroviral genome replication|regulation of retroviral genome replication http://purl.obolibrary.org/obo/GO_0045869 GO:0070803 biolink:BiologicalProcess negative regulation of metula development Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. go.json http://purl.obolibrary.org/obo/GO_0070803 GO:0070800 biolink:BiologicalProcess negative regulation of conidiophore stalk development Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. go.json http://purl.obolibrary.org/obo/GO_0070800 GO:0045866 biolink:BiologicalProcess obsolete positive regulation of recombination within rDNA repeats OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. go.json positive regulation of recombination within rDNA repeats True http://purl.obolibrary.org/obo/GO_0045866 GO:0070801 biolink:BiologicalProcess positive regulation of conidiophore stalk development Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. go.json http://purl.obolibrary.org/obo/GO_0070801 GO:0045867 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045867 GO:0031234 biolink:CellularComponent extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. go.json extrinsic to cytoplasmic side of plasma membrane|extrinsic to internal leaflet of plasma membrane|extrinsic to internal side of plasma membrane http://purl.obolibrary.org/obo/GO_0031234 GO:0031235 biolink:CellularComponent obsolete intrinsic component of the cytoplasmic side of the plasma membrane OBSOLETE. The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. go.json intrinsic to cytoplasmic side of plasma membrane|intrinsic to internal leaflet of plasma membrane|intrinsic to internal side of plasma membrane True http://purl.obolibrary.org/obo/GO_0031235 GO:0031232 biolink:CellularComponent extrinsic component of external side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. go.json extrinsic to external leaflet of plasma membrane|extrinsic to external side of plasma membrane http://purl.obolibrary.org/obo/GO_0031232 GO:0031233 biolink:CellularComponent obsolete intrinsic component of external side of plasma membrane OBSOLETE. The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. go.json intrinsic to external leaflet of plasma membrane|intrinsic to external side of plasma membrane True http://purl.obolibrary.org/obo/GO_0031233 GO:0031230 biolink:CellularComponent obsolete intrinsic component of cell outer membrane OBSOLETE. The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to cell outer membrane True http://purl.obolibrary.org/obo/GO_0031230 GO:0031231 biolink:CellularComponent obsolete intrinsic component of peroxisomal membrane OBSOLETE. The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to peroxisomal membrane True http://purl.obolibrary.org/obo/GO_0031231 GO:0080193 biolink:BiologicalProcess diffuse secondary thickening Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem. go.json http://purl.obolibrary.org/obo/GO_0080193 GO:0080190 biolink:BiologicalProcess lateral growth Growth of a plant axis (shoot axis or root) that originates from a lateral meristem. go.json http://purl.obolibrary.org/obo/GO_0080190 GO:0080191 biolink:BiologicalProcess secondary thickening Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem. go.json http://purl.obolibrary.org/obo/GO_0080191 GO:0080192 biolink:BiologicalProcess primary thickening Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem. go.json http://purl.obolibrary.org/obo/GO_0080192 GO:0080186 biolink:BiologicalProcess developmental vegetative growth The increase in size or mass of non-reproductive plant parts. go.json http://purl.obolibrary.org/obo/GO_0080186 GO:0080187 biolink:BiologicalProcess floral organ senescence The last stage of flower development during which programmed degradation of macromolecules and nutrient recycling take place. go.json http://purl.obolibrary.org/obo/GO_0080187 GO:0080188 biolink:BiologicalProcess gene silencing by RNA-directed DNA methylation A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. go.json RNA-directed DNA methylation|RdDM http://purl.obolibrary.org/obo/GO_0080188 GO:0080189 biolink:BiologicalProcess primary growth Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed. go.json http://purl.obolibrary.org/obo/GO_0080189 GO:0080182 biolink:BiologicalProcess histone H3-K4 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. go.json http://purl.obolibrary.org/obo/GO_0080182 gocheck_do_not_annotate GO:0080183 biolink:BiologicalProcess response to photooxidative stress Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. go.json http://purl.obolibrary.org/obo/GO_0080183 GO:0080184 biolink:BiologicalProcess response to phenylpropanoid Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. go.json http://purl.obolibrary.org/obo/GO_0080184 GO:0080185 biolink:BiologicalProcess effector-mediated activation of plant hypersensitive response by symbiont A symbiont process in which a molecule secreted by the symbiont activates a resistance gene-dependent defense response signaling pathway in the plant host, in order to activate a hypersensitive response to induce necrosis. In the plant, this process involves the direct or indirect recognition of the symbiont effector protein for example through plant resistance receptor or R proteins (or R genes). Wikipedia:Effector-triggered_immunity go.json ETI triggered of host innate immune response|ETI-triggered of host innate immune response|activation by organism of defense response in host by specific elicitors|activation by organism of host gene-for-gene resistance|activation by organism of host resistance gene-dependent defense response|activation by symbiont of host resistance gene-dependent defense response|activation of HR|activation of hypersensitive response|avirulence protein|effector-mediated induction of plant hypersensitive response by symbiont|effector-triggered immunity|effector-triggered induction of host innate immune response|effector-triggered induction of plant hypersensitive response by symbiont|effector-triggered necrosis|induction by organism of defense response in host by specific elicitors|induction by organism of host gene-for-gene resistance|induction by organism of pathogen-race/host plant cultivar-specific resistance in host|induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction|induction by symbiont of host resistance gene-dependent defense response|induction of effector-triggered immunity (ETI)|necrotrophic effector|positive regulation by organism of defense response in host by specific elicitors|positive regulation by organism of host gene-for-gene resistance|positive regulation by symbiont of host resistance gene-dependent defense response|positive regulation by symbiont of plant HR|positive regulation by symbiont of plant hypersensitive response http://purl.obolibrary.org/obo/GO_0080185 GO:0080180 biolink:BiologicalProcess 2-methylguanosine metabolic process The chemical reactions and pathways involving 2-methylguanosine. go.json http://purl.obolibrary.org/obo/GO_0080180 GO:0080181 biolink:BiologicalProcess lateral root branching Any process involved in the formation of branches in lateral roots. go.json http://purl.obolibrary.org/obo/GO_0080181 GO:0031193 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031193 GO:0031194 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031194 GO:0031191 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031191 GO:0031192 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031192 GO:0031190 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031190 GO:0031199 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031199 GO:0031197 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031197 GO:0031198 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031198 GO:0031195 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031195 GO:0031196 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031196 GO:0070790 biolink:BiologicalProcess phialide development The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips. go.json development of secondary sterigmata http://purl.obolibrary.org/obo/GO_0070790 GO:0070791 biolink:BiologicalProcess cleistothecium development The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. go.json http://purl.obolibrary.org/obo/GO_0070791 GO:0080117 biolink:BiologicalProcess secondary growth Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium. go.json cambial secondary growth http://purl.obolibrary.org/obo/GO_0080117 GO:0080118 biolink:MolecularActivity brassinosteroid sulfotransferase activity Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative. go.json http://purl.obolibrary.org/obo/GO_0080118 GO:0080119 biolink:BiologicalProcess ER body organization A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species. go.json ER body organisation|ER body organization and biogenesis|endoplasmic reticulum body organization|endoplasmic reticulum body organization and biogenesis http://purl.obolibrary.org/obo/GO_0080119 GO:0080113 biolink:BiologicalProcess regulation of seed growth Any process that modulates the frequency, rate or extent of growth of the seed of an plant. go.json regulation of seed size http://purl.obolibrary.org/obo/GO_0080113 GO:0080114 biolink:BiologicalProcess positive regulation of glycine hydroxymethyltransferase activity Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. go.json http://purl.obolibrary.org/obo/GO_0080114 gocheck_do_not_annotate GO:0080115 biolink:MolecularActivity myosin XI tail binding Binding to the tail region of a myosin XI heavy chain. go.json http://purl.obolibrary.org/obo/GO_0080115 GO:0080116 biolink:MolecularActivity glucuronoxylan glucuronosyltransferase activity Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule. go.json http://purl.obolibrary.org/obo/GO_0080116 GO:0080110 biolink:BiologicalProcess sporopollenin biosynthetic process The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer. go.json sporopollenin biosynthesis http://purl.obolibrary.org/obo/GO_0080110 GO:0080111 biolink:BiologicalProcess DNA demethylation The removal of a methyl group from one or more nucleotides within an DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0080111 GO:0080112 biolink:BiologicalProcess seed growth The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo. go.json http://purl.obolibrary.org/obo/GO_0080112 GO:0021828 biolink:BiologicalProcess gonadotrophin-releasing hormone neuronal migration to the hypothalamus The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus. go.json gonadotropin-releasing hormone neuronal migration to the hypothalamus http://purl.obolibrary.org/obo/GO_0021828 GO:0021829 biolink:BiologicalProcess oligodendrocyte cell migration from the subpallium to the cortex The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development. go.json http://purl.obolibrary.org/obo/GO_0021829 GO:0070798 biolink:BiologicalProcess positive regulation of cleistothecium development Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. go.json http://purl.obolibrary.org/obo/GO_0070798 GO:0021820 biolink:BiologicalProcess extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells. go.json extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration|organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021820 GO:0021821 biolink:BiologicalProcess negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. go.json down regulation of cell-glial cell adhesion involved in cerebral cortex lamination|down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination|downregulation of cell-glial cell adhesion involved in cerebral cortex lamination|inhibition of cell-glial cell adhesion involved in cerebral cortex lamination http://purl.obolibrary.org/obo/GO_0021821 GO:0070799 biolink:BiologicalProcess regulation of conidiophore stalk development Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. go.json http://purl.obolibrary.org/obo/GO_0070799 GO:0021822 biolink:BiologicalProcess negative regulation of cell motility involved in cerebral cortex radial glia guided migration The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex. go.json down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration|negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration http://purl.obolibrary.org/obo/GO_0021822 GO:0070796 biolink:BiologicalProcess regulation of cleistothecium development Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. go.json http://purl.obolibrary.org/obo/GO_0070796 GO:0021823 biolink:BiologicalProcess cerebral cortex tangential migration using cell-cell interactions The process in which neurons interact with each other to promote migration along a tangential plane. go.json chain migration http://purl.obolibrary.org/obo/GO_0021823 GO:0070797 biolink:BiologicalProcess negative regulation of cleistothecium development Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. go.json http://purl.obolibrary.org/obo/GO_0070797 GO:0070794 biolink:BiologicalProcess negative regulation of conidiophore development Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. go.json http://purl.obolibrary.org/obo/GO_0070794 GO:0021824 biolink:BiologicalProcess cerebral cortex tangential migration using cell-axon interactions The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons. go.json http://purl.obolibrary.org/obo/GO_0021824 GO:0070795 biolink:BiologicalProcess positive regulation of conidiophore development Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. go.json http://purl.obolibrary.org/obo/GO_0070795 GO:0021825 biolink:BiologicalProcess substrate-dependent cerebral cortex tangential migration The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions. go.json http://purl.obolibrary.org/obo/GO_0021825 GO:0070792 biolink:BiologicalProcess Hulle cell development The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. go.json Huelle cell development|Hulle cell formation http://purl.obolibrary.org/obo/GO_0070792 GO:0021826 biolink:BiologicalProcess substrate-independent telencephalic tangential migration The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. go.json http://purl.obolibrary.org/obo/GO_0021826 GO:0070793 biolink:BiologicalProcess regulation of conidiophore development Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. go.json http://purl.obolibrary.org/obo/GO_0070793 GO:0021827 biolink:BiologicalProcess postnatal olfactory bulb interneuron migration The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth. go.json http://purl.obolibrary.org/obo/GO_0021827 GO:0070780 biolink:MolecularActivity dihydrosphingosine-1-phosphate phosphatase activity Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate. MetaCyc:RXN3DJ-25|RHEA:27514|Reactome:R-HSA-428664 go.json dihydrosphingosine-1-phosphate phosphohydrolase activity|sphinganine-1-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0070780 GO:0080106 biolink:MolecularActivity 7-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate. go.json http://purl.obolibrary.org/obo/GO_0080106 GO:0080107 biolink:MolecularActivity 8-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate. go.json http://purl.obolibrary.org/obo/GO_0080107 GO:0080108 biolink:MolecularActivity S-alkylthiohydroximate lyase activity Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate. go.json S-alkylthiohydroximate C-S lyase activity http://purl.obolibrary.org/obo/GO_0080108 GO:0080109 biolink:MolecularActivity indole-3-acetonitrile nitrile hydratase activity Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide. EC:4.2.1.84|KEGG_REACTION:R04020|MetaCyc:RXN-7567 go.json http://purl.obolibrary.org/obo/GO_0080109 GO:0080102 biolink:MolecularActivity 3-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate. MetaCyc:RXN-2221 go.json http://purl.obolibrary.org/obo/GO_0080102 GO:0080103 biolink:MolecularActivity 4-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate. go.json http://purl.obolibrary.org/obo/GO_0080103 GO:0080104 biolink:MolecularActivity 5-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate. go.json http://purl.obolibrary.org/obo/GO_0080104 GO:0080105 biolink:MolecularActivity 6-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate. go.json http://purl.obolibrary.org/obo/GO_0080105 GO:0080100 biolink:MolecularActivity L-glutamine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate. EC:2.6.1.50 go.json L-glutamine:alpha-ketoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0080100 GO:0080101 biolink:MolecularActivity phosphatidyl-N-dimethylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine. EC:2.1.1.71|KEGG_REACTION:R01320|MetaCyc:RXN4FS-2|RHEA:32739 go.json http://purl.obolibrary.org/obo/GO_0080101 GO:0021817 biolink:BiologicalProcess nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration. go.json nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration|nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration http://purl.obolibrary.org/obo/GO_0021817 GO:0021818 biolink:BiologicalProcess obsolete modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration OBSOLETE. The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. go.json modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration True http://purl.obolibrary.org/obo/GO_0021818 GO:0021819 biolink:BiologicalProcess layer formation in cerebral cortex The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. go.json cerebral cortex lamination http://purl.obolibrary.org/obo/GO_0021819 GO:0070789 biolink:BiologicalProcess metula development The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. go.json development of primary sterigmata http://purl.obolibrary.org/obo/GO_0070789 GO:0070787 biolink:BiologicalProcess conidiophore development The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. go.json http://purl.obolibrary.org/obo/GO_0070787 GO:0021810 biolink:BiologicalProcess neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration. go.json neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021810 GO:0070788 biolink:BiologicalProcess conidiophore stalk development The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. go.json http://purl.obolibrary.org/obo/GO_0070788 GO:0070785 biolink:BiologicalProcess negative regulation of growth of unicellular organism as a thread of attached cells Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. go.json http://purl.obolibrary.org/obo/GO_0070785 GO:0021811 biolink:BiologicalProcess growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex. go.json growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration|growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021811 GO:0021812 biolink:BiologicalProcess neuronal-glial interaction involved in cerebral cortex radial glia guided migration The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. go.json neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021812 GO:0070786 biolink:BiologicalProcess positive regulation of growth of unicellular organism as a thread of attached cells Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. go.json http://purl.obolibrary.org/obo/GO_0070786 GO:0021813 biolink:BiologicalProcess cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex. go.json cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021813 GO:0070783 biolink:BiologicalProcess growth of unicellular organism as a thread of attached cells A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions. go.json http://purl.obolibrary.org/obo/GO_0070783 goslim_candida GO:0070784 biolink:BiologicalProcess regulation of growth of unicellular organism as a thread of attached cells Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. go.json http://purl.obolibrary.org/obo/GO_0070784 GO:0021814 biolink:BiologicalProcess cell motility involved in cerebral cortex radial glia guided migration The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration. go.json cell locomotion involved in cerebral cortex glial-mediated radial migration|cell locomotion involved in cerebral cortex radial glia guided migration http://purl.obolibrary.org/obo/GO_0021814 GO:0021815 biolink:BiologicalProcess modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration. go.json modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021815 GO:0070781 biolink:BiologicalProcess response to biotin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus. go.json response to Bios IIB|response to coenzyme R|response to vitamin B7|response to vitamin H http://purl.obolibrary.org/obo/GO_0070781 GO:0070782 biolink:BiologicalProcess phosphatidylserine exposure on apoptotic cell surface A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity. go.json externalization of phosphatidylserine http://purl.obolibrary.org/obo/GO_0070782 GO:0021816 biolink:BiologicalProcess extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells. go.json http://purl.obolibrary.org/obo/GO_0021816 GO:0080139 biolink:MolecularActivity borate efflux transmembrane transporter activity Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane. go.json boron efflux transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0080139 GO:0080135 biolink:BiologicalProcess regulation of cellular response to stress Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0080135 GO:0080136 biolink:BiologicalProcess priming of cellular response to stress The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress. go.json priming of response to stress|priming of stress response http://purl.obolibrary.org/obo/GO_0080136 GO:0080137 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080137 GO:0080138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080138 GO:0080131 biolink:MolecularActivity hydroxyjasmonate sulfotransferase activity Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate. go.json 11-OHJA sulfotransferase activity|11-hydroxyjasmonate sulfotransferase activity|11-hydroxyjasmonic acid sulfotransferase activity|12-OHJA sulfotransferase activity|12-hydroxyjasmonate sulfotransferase activity|12-hydroxyjasmonic acid sulfotransferase activity|OHJA sulfotransferase activity|hydroxyjasmonic acid sulfotransferase activity http://purl.obolibrary.org/obo/GO_0080131 GO:0080132 biolink:MolecularActivity fatty acid alpha-hydroxylase activity Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain. Reactome:R-HSA-5693761 go.json fatty acid 2-hydroxylase http://purl.obolibrary.org/obo/GO_0080132 GO:0080133 biolink:MolecularActivity midchain alkane hydroxylase activity Catalysis of the conversion of an alkane to a secondary alcohol. go.json http://purl.obolibrary.org/obo/GO_0080133 GO:0080134 biolink:BiologicalProcess regulation of response to stress Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0080134 gocheck_do_not_manually_annotate GO:0021806 biolink:BiologicalProcess initiation of movement involved in cerebral cortex radial glia guided migration The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex. go.json initiation of movement involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021806 GO:0021807 biolink:BiologicalProcess motogenic signaling initiating cell movement in cerebral cortex The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex. go.json motogenic signalling initiating cell movement in the cerebral cortex http://purl.obolibrary.org/obo/GO_0021807 GO:0021808 biolink:BiologicalProcess cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration. go.json cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration http://purl.obolibrary.org/obo/GO_0021808 GO:0080130 biolink:MolecularActivity L-phenylalanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate. EC:2.6.1.57|KEGG_REACTION:R00694|MetaCyc:RXN-10814|RHEA:25152 go.json L-phenylalanine:alpha-ketoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0080130 GO:0021809 biolink:BiologicalProcess neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration. go.json neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration http://purl.obolibrary.org/obo/GO_0021809 GO:0021800 biolink:BiologicalProcess cerebral cortex tangential migration The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. go.json http://purl.obolibrary.org/obo/GO_0021800 GO:0021801 biolink:BiologicalProcess cerebral cortex radial glia-guided migration The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. go.json cerebral cortex radial glia guided migration|cerebral cortex radial glia-dependent cell migration|glial-guided locomotion http://purl.obolibrary.org/obo/GO_0021801 GO:0021802 biolink:BiologicalProcess somal translocation The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate. go.json perikaryal translocation of Morest http://purl.obolibrary.org/obo/GO_0021802 GO:0021803 biolink:BiologicalProcess extension of leading cell process to pial surface The extension of a long process to the pial surface as a cell leaves the ventricular zone. go.json http://purl.obolibrary.org/obo/GO_0021803 GO:0021804 biolink:BiologicalProcess negative regulation of cell adhesion in ventricular zone The process that results in the loss of attachments of a cell in the ventricular zone. go.json down regulation of cell adhesion in ventricular zone|down-regulation of cell adhesion in ventricular zone|downregulation of cell adhesion in ventricular zone|inhibition of cell adhesion in ventricular zone http://purl.obolibrary.org/obo/GO_0021804 GO:0021805 biolink:BiologicalProcess cell movement involved in somal translocation The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface. go.json cell motility involved in somal translocation http://purl.obolibrary.org/obo/GO_0021805 GO:0080128 biolink:BiologicalProcess anther septum development The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone. go.json http://purl.obolibrary.org/obo/GO_0080128 GO:0080129 biolink:BiologicalProcess proteasome core complex assembly The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles. go.json 20S proteasome assembly http://purl.obolibrary.org/obo/GO_0080129 GO:0080124 biolink:MolecularActivity pheophytinase activity Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide. go.json pheophytin pheophorbide hydrolase activity http://purl.obolibrary.org/obo/GO_0080124 GO:0080125 biolink:BiologicalProcess obsolete multicellular structure septum development OBSOLETE. The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue. go.json True http://purl.obolibrary.org/obo/GO_0080125 GO:0080126 biolink:BiologicalProcess ovary septum development The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s). go.json http://purl.obolibrary.org/obo/GO_0080126 GO:0080127 biolink:BiologicalProcess fruit septum development The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit. go.json http://purl.obolibrary.org/obo/GO_0080127 GO:0080120 biolink:BiologicalProcess CAAX-box protein maturation A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase. go.json CAAX-box protein processing|farnesylated protein maturation http://purl.obolibrary.org/obo/GO_0080120 GO:0080121 biolink:BiologicalProcess AMP transport The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json adenosine monophosphate transport http://purl.obolibrary.org/obo/GO_0080121 GO:0080122 biolink:MolecularActivity AMP transmembrane transporter activity Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other. go.json adenosine monophosphate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0080122 GO:0080123 biolink:MolecularActivity jasmonate-amino synthetase activity Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate). go.json ja-amino synthetase activity|jasmonate-amido synthetase activity|jasmonate-amino acid conjugate synthetase activity|jasmonate-amino acid synthetase activity|jasmonate:amino acid synthetase activity|jasmonic acid-amino synthetase activity|jasmonyl-amino synthetase activity http://purl.obolibrary.org/obo/GO_0080123 GO:0080157 biolink:BiologicalProcess regulation of plant-type cell wall organization or biogenesis Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall. go.json regulation of plant-type cell wall organisation or biogenesis http://purl.obolibrary.org/obo/GO_0080157 GO:0080158 biolink:BiologicalProcess obsolete chloroplast ribulose bisphosphate carboxylase complex biogenesis OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a chloroplast ribulose bisphosphate carboxylase (RubisCO) complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. go.json True http://purl.obolibrary.org/obo/GO_0080158 GO:0080159 biolink:BiologicalProcess zygote elongation The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0080159 GO:0080153 biolink:BiologicalProcess negative regulation of reductive pentose-phosphate cycle Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle. go.json negative regulation of C3 photosynthesis|negative regulation of Calvin cycle http://purl.obolibrary.org/obo/GO_0080153 GO:0080154 biolink:BiologicalProcess regulation of fertilization Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). go.json http://purl.obolibrary.org/obo/GO_0080154 GO:0080155 biolink:BiologicalProcess regulation of double fertilization forming a zygote and endosperm Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0080155 GO:0080156 biolink:BiologicalProcess mitochondrial mRNA modification The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically. go.json mitochondrial RNA editing|mitochondrial mRNA editing http://purl.obolibrary.org/obo/GO_0080156 GO:0080150 biolink:MolecularActivity S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine. MetaCyc:RXN-6722|RHEA:36099 go.json S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity http://purl.obolibrary.org/obo/GO_0080150 GO:0080151 biolink:BiologicalProcess positive regulation of salicylic acid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction. go.json positive regulation of salicylic acid mediated signalling pathway http://purl.obolibrary.org/obo/GO_0080151 GO:0080152 biolink:BiologicalProcess regulation of reductive pentose-phosphate cycle Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle. go.json regulation of C3 photosynthesis|regulation of Calvin cycle http://purl.obolibrary.org/obo/GO_0080152 GO:0080146 biolink:MolecularActivity L-cysteine desulfhydrase activity Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+. EC:4.4.1.1|MetaCyc:LCYSDESULF-RXN|RHEA:24931|Reactome:R-HSA-1614591|Reactome:R-HSA-1614614 go.json http://purl.obolibrary.org/obo/GO_0080146 GO:0080147 biolink:BiologicalProcess root hair cell development The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0080147 GO:0080148 biolink:BiologicalProcess negative regulation of response to water deprivation Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. go.json http://purl.obolibrary.org/obo/GO_0080148 GO:0080149 biolink:BiologicalProcess sucrose induced translational repression Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level. go.json negative regulation of translation in response to sucrose http://purl.obolibrary.org/obo/GO_0080149 GO:0080142 biolink:BiologicalProcess regulation of salicylic acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid. go.json http://purl.obolibrary.org/obo/GO_0080142 GO:0080143 biolink:BiologicalProcess regulation of amino acid export Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0080143 GO:0080144 biolink:BiologicalProcess intracellular amino acid homeostasis A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell. go.json amino acid homeostasis|cellular amino acid homeostasis http://purl.obolibrary.org/obo/GO_0080144 GO:0080145 biolink:BiologicalProcess intracellular cysteine homeostasis A homeostatic process involved in the maintenance of a steady state level of cysteine within a cell. go.json cellular cysteine homeostasis|cysteine homeostasis http://purl.obolibrary.org/obo/GO_0080145 GO:0080140 biolink:BiologicalProcess regulation of jasmonic acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid. go.json http://purl.obolibrary.org/obo/GO_0080140 GO:0080141 biolink:BiologicalProcess regulation of jasmonic acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid. go.json http://purl.obolibrary.org/obo/GO_0080141 GO:0080179 biolink:BiologicalProcess 1-methylguanosine metabolic process The chemical reactions and pathways involving 1-methylguanosine. go.json http://purl.obolibrary.org/obo/GO_0080179 GO:0080175 biolink:BiologicalProcess phragmoplast microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells. go.json phragmoplast microtubule cytoskeleton organization|phragmoplast microtubule organisation http://purl.obolibrary.org/obo/GO_0080175 GO:0080176 biolink:MolecularActivity xyloglucan 1,6-alpha-xylosidase activity Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus. go.json http://purl.obolibrary.org/obo/GO_0080176 GO:0080177 biolink:BiologicalProcess plastoglobule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. go.json plastoglobule organisation http://purl.obolibrary.org/obo/GO_0080177 GO:0080178 biolink:BiologicalProcess 5-carbamoylmethyl uridine residue modification The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA. go.json 5-carbamoylmethyluridine metabolic process http://purl.obolibrary.org/obo/GO_0080178 GO:0080171 biolink:BiologicalProcess lytic vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. go.json lytic vacuolar assembly|lytic vacuole biogenesis|lytic vacuole organisation|lytic vacuole organization and biogenesis http://purl.obolibrary.org/obo/GO_0080171 GO:0080172 biolink:BiologicalProcess petal epidermis patterning The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis. go.json http://purl.obolibrary.org/obo/GO_0080172 GO:0080173 biolink:BiologicalProcess male-female gamete recognition during double fertilization forming a zygote and endosperm The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana. go.json gamete recognition|male-female gamete recognition http://purl.obolibrary.org/obo/GO_0080173 GO:0080174 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0080174 GO:0080170 biolink:BiologicalProcess hydrogen peroxide transmembrane transport The process in which hydrogen peroxide is transported across a membrane. go.json hydrogen peroxide membrane transport http://purl.obolibrary.org/obo/GO_0080170 GO:0080168 biolink:BiologicalProcess abscisic acid transport The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0080168 GO:0080169 biolink:BiologicalProcess cellular response to boron-containing substance deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances. go.json cellular response to boron deprivation|cellular response to boron starvation http://purl.obolibrary.org/obo/GO_0080169 GO:0080164 biolink:BiologicalProcess regulation of nitric oxide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. go.json http://purl.obolibrary.org/obo/GO_0080164 GO:0080165 biolink:BiologicalProcess callose deposition in phloem sieve plate Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. go.json http://purl.obolibrary.org/obo/GO_0080165 GO:0080166 biolink:BiologicalProcess stomium development The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released. go.json http://purl.obolibrary.org/obo/GO_0080166 GO:0080167 biolink:BiologicalProcess response to karrikin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants). go.json http://purl.obolibrary.org/obo/GO_0080167 GO:0080160 biolink:BiologicalProcess selenate transport The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0080160 GO:0080161 biolink:MolecularActivity auxin transmembrane transporter activity Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth. go.json http://purl.obolibrary.org/obo/GO_0080161 GO:0080162 biolink:BiologicalProcess endoplasmic reticulum to cytosol auxin transport The directed movement of auxins from endoplasmic reticulum to cytosol. go.json intracellular auxin transport http://purl.obolibrary.org/obo/GO_0080162 GO:0080163 biolink:BiologicalProcess regulation of protein serine/threonine phosphatase activity Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. go.json regulation of protein phosphatase type 2c activity http://purl.obolibrary.org/obo/GO_0080163 gocheck_do_not_annotate GO:0031348 biolink:BiologicalProcess negative regulation of defense response Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. go.json down regulation of defense response|down-regulation of defense response|downregulation of defense response|inhibition of defense response http://purl.obolibrary.org/obo/GO_0031348 GO:0031349 biolink:BiologicalProcess positive regulation of defense response Any process that activates or increases the frequency, rate or extent of a defense response. go.json activation of defense response|stimulation of defense response|up regulation of defense response|up-regulation of defense response|upregulation of defense response http://purl.obolibrary.org/obo/GO_0031349 GO:0031346 biolink:BiologicalProcess positive regulation of cell projection organization Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. go.json activation of cell projection organization|positive regulation of cell projection organisation|positive regulation of cell projection organization and biogenesis|stimulation of cell projection organization|up regulation of cell projection organization|up-regulation of cell projection organization|upregulation of cell projection organization http://purl.obolibrary.org/obo/GO_0031346 GO:0031347 biolink:BiologicalProcess regulation of defense response Any process that modulates the frequency, rate or extent of a defense response. go.json http://purl.obolibrary.org/obo/GO_0031347 GO:0045996 biolink:BiologicalProcess obsolete negative regulation of transcription by pheromones OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription. go.json down regulation of transcription by pheromones|down-regulation of transcription by pheromones|downregulation of transcription by pheromones|inhibition of transcription by pheromones True http://purl.obolibrary.org/obo/GO_0045996 GO:0006388 biolink:BiologicalProcess tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. go.json tRNA-Y splicing http://purl.obolibrary.org/obo/GO_0006388 GO:0006389 biolink:BiologicalProcess obsolete tRNA-Y splicing OBSOLETE. (Was not defined before being made obsolete). go.json tRNA-Y splicing True http://purl.obolibrary.org/obo/GO_0006389 GO:0045997 biolink:BiologicalProcess negative regulation of ecdysteroid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. go.json down regulation of ecdysteroid biosynthetic process|down-regulation of ecdysteroid biosynthetic process|downregulation of ecdysteroid biosynthetic process|inhibition of ecdysteroid biosynthetic process|negative regulation of ecdysteroid anabolism|negative regulation of ecdysteroid biosynthesis|negative regulation of ecdysteroid formation|negative regulation of ecdysteroid synthesis http://purl.obolibrary.org/obo/GO_0045997 GO:0006386 biolink:BiologicalProcess termination of RNA polymerase III transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues. go.json RNA polymerase III transcription termination|RNA polymerase III transcription termination factor activity|transcription termination from Pol III promoter|transcription termination from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0006386 GO:0045994 biolink:BiologicalProcess positive regulation of translational initiation by iron Any process involving iron that activates or increases the rate of translational initiation. go.json activation of translational initiation by iron|stimulation of translational initiation by iron|up regulation of translational initiation by iron|up-regulation of translational initiation by iron|upregulation of translational initiation by iron http://purl.obolibrary.org/obo/GO_0045994 GO:0006387 biolink:BiologicalProcess obsolete snRNA capping OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript. go.json snRNA capping True http://purl.obolibrary.org/obo/GO_0006387 GO:0045995 biolink:BiologicalProcess regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development. go.json http://purl.obolibrary.org/obo/GO_0045995 GO:0006384 biolink:BiologicalProcess transcription initiation at RNA polymerase III promoter A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III. go.json transcription initiation from Pol III promoter|transcription initiation from RNA polymerase III hybrid type promoter|transcription initiation from RNA polymerase III promoter|transcription initiation from RNA polymerase III type 1 promoter|transcription initiation from RNA polymerase III type 2 promoter|transcription initiation from RNA polymerase III type 3 promoter http://purl.obolibrary.org/obo/GO_0006384 GO:0045992 biolink:BiologicalProcess negative regulation of embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. go.json down regulation of embryonic development|down-regulation of embryonic development|downregulation of embryonic development|inhibition of embryonic development http://purl.obolibrary.org/obo/GO_0045992 GO:0045993 biolink:BiologicalProcess negative regulation of translational initiation by iron Any process involving iron that stops, prevents or reduces the rate of translational initiation. go.json down regulation of translational initiation by iron|down-regulation of translational initiation by iron|downregulation of translational initiation by iron|inhibition of translational initiation by iron http://purl.obolibrary.org/obo/GO_0045993 GO:0006385 biolink:BiologicalProcess transcription elongation by RNA polymerase III The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III. go.json RNA elongation from Pol III promoter|RNA polymerase III transcription elongation factor activity|transcription elongation by RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0006385 GO:0045990 biolink:BiologicalProcess carbon catabolite regulation of transcription A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. go.json regulation of transcription by carbon catabolites http://purl.obolibrary.org/obo/GO_0045990 GO:0006382 biolink:BiologicalProcess adenosine to inosine editing The conversion of an adenosine residue to inosine in an RNA molecule by deamination. go.json http://purl.obolibrary.org/obo/GO_0006382 GO:0006383 biolink:BiologicalProcess transcription by RNA polymerase III The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. go.json RNA polymerase III transcription factor activity|U2 snRNA transcription (S. cerevisiae)|U6 snRNA transcription (mammalian)|transcription from Pol III promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase III type 2 promoter|transcription from RNA polymerase III type 3 promoter|transcription from a RNA polymerase III hybrid type promoter http://purl.obolibrary.org/obo/GO_0006383 goslim_yeast GO:0045991 biolink:BiologicalProcess carbon catabolite activation of transcription A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. go.json positive regulation of transcription by carbon catabolites http://purl.obolibrary.org/obo/GO_0045991 GO:0006391 biolink:BiologicalProcess transcription initiation at mitochondrial promoter A transcription initiation process that takes place at a promoter on the mitochondrial chromosome. go.json transcription initiation from mitochondrial promoter http://purl.obolibrary.org/obo/GO_0006391 GO:0006392 biolink:BiologicalProcess transcription elongation by mitochondrial RNA polymerase The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase. go.json RNA elongation from mitochondrial promoter|transcription elongation from mitochondrial promoter http://purl.obolibrary.org/obo/GO_0006392 GO:0070958 biolink:BiologicalProcess negative regulation of neutrophil mediated killing of gram-positive bacterium Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil. go.json down regulation of neutrophil mediated killing of gram-positive bacterium|down-regulation of neutrophil mediated killing of gram-positive bacterium|downregulation of neutrophil mediated killing of gram-positive bacterium|inhibition of neutrophil mediated killing of gram-positive bacterium http://purl.obolibrary.org/obo/GO_0070958 GO:0070959 biolink:BiologicalProcess negative regulation of neutrophil mediated killing of fungus Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil. go.json down regulation of neutrophil mediated killing of fungus|down-regulation of neutrophil mediated killing of fungus|downregulation of neutrophil mediated killing of fungus|inhibition of neutrophil mediated killing of fungus http://purl.obolibrary.org/obo/GO_0070959 GO:0006390 biolink:BiologicalProcess mitochondrial transcription The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. go.json transcription from mitochondrial promoter http://purl.obolibrary.org/obo/GO_0006390 GO:0070956 biolink:BiologicalProcess negative regulation of neutrophil mediated killing of bacterium Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil. go.json down regulation of neutrophil mediated killing of bacterium|down-regulation of neutrophil mediated killing of bacterium|downregulation of neutrophil mediated killing of bacterium|inhibition of neutrophil mediated killing of bacterium http://purl.obolibrary.org/obo/GO_0070956 GO:0070957 biolink:BiologicalProcess negative regulation of neutrophil mediated killing of gram-negative bacterium Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil. go.json down regulation of neutrophil mediated killing of gram-negative bacterium|down-regulation of neutrophil mediated killing of gram-negative bacterium|downregulation of neutrophil mediated killing of gram-negative bacterium|inhibition of neutrophil mediated killing of gram-negative bacterium http://purl.obolibrary.org/obo/GO_0070957 GO:0070954 biolink:BiologicalProcess negative regulation of neutrophil mediated cytotoxicity Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil. go.json down regulation of neutrophil mediated cytotoxicity|down-regulation of neutrophil mediated cytotoxicity|downregulation of neutrophil mediated cytotoxicity|inhibition of neutrophil mediated cytotoxicity|negative regulation of neutrophil mediated cell killing http://purl.obolibrary.org/obo/GO_0070954 GO:0045998 biolink:BiologicalProcess positive regulation of ecdysteroid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. go.json activation of ecdysteroid biosynthetic process|positive regulation of ecdysteroid anabolism|positive regulation of ecdysteroid biosynthesis|positive regulation of ecdysteroid formation|positive regulation of ecdysteroid synthesis|stimulation of ecdysteroid biosynthetic process|up regulation of ecdysteroid biosynthetic process|up-regulation of ecdysteroid biosynthetic process|upregulation of ecdysteroid biosynthetic process http://purl.obolibrary.org/obo/GO_0045998 GO:0045999 biolink:BiologicalProcess negative regulation of ecdysteroid secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid. go.json down regulation of ecdysteroid secretion|down-regulation of ecdysteroid secretion|downregulation of ecdysteroid secretion|inhibition of ecdysteroid secretion http://purl.obolibrary.org/obo/GO_0045999 GO:0070955 biolink:BiologicalProcess negative regulation of neutrophil mediated killing of symbiont cell Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil. go.json down regulation of neutrophil mediated killing of symbiont cell|down-regulation of neutrophil mediated killing of symbiont cell|downregulation of neutrophil mediated killing of symbiont cell|inhibition of neutrophil mediated killing of symbiont cell http://purl.obolibrary.org/obo/GO_0070955 GO:0070952 biolink:BiologicalProcess regulation of neutrophil mediated killing of gram-positive bacterium Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil. go.json http://purl.obolibrary.org/obo/GO_0070952 GO:0031344 biolink:BiologicalProcess regulation of cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. go.json regulation of cell projection organisation|regulation of cell projection organization and biogenesis http://purl.obolibrary.org/obo/GO_0031344 GO:0070953 biolink:BiologicalProcess regulation of neutrophil mediated killing of fungus Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil. go.json http://purl.obolibrary.org/obo/GO_0070953 GO:0031345 biolink:BiologicalProcess negative regulation of cell projection organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. go.json down regulation of cell projection organization|down-regulation of cell projection organization|downregulation of cell projection organization|inhibition of cell projection organization|negative regulation of cell projection organisation|negative regulation of cell projection organization and biogenesis http://purl.obolibrary.org/obo/GO_0031345 GO:0031342 biolink:BiologicalProcess negative regulation of cell killing Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. go.json down regulation of cell killing|down-regulation of cell killing|downregulation of cell killing|inhibition of cell killing http://purl.obolibrary.org/obo/GO_0031342 GO:0070950 biolink:BiologicalProcess regulation of neutrophil mediated killing of bacterium Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil. go.json http://purl.obolibrary.org/obo/GO_0070950 GO:0070951 biolink:BiologicalProcess regulation of neutrophil mediated killing of gram-negative bacterium Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil. go.json http://purl.obolibrary.org/obo/GO_0070951 GO:0031343 biolink:BiologicalProcess positive regulation of cell killing Any process that activates or increases the frequency, rate or extent of cell killing. go.json activation of cell killing|stimulation of cell killing|up regulation of cell killing|up-regulation of cell killing|upregulation of cell killing http://purl.obolibrary.org/obo/GO_0031343 GO:0031340 biolink:BiologicalProcess positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion. go.json activation of vesicle fusion|stimulation of vesicle fusion|up regulation of vesicle fusion|up-regulation of vesicle fusion|upregulation of vesicle fusion http://purl.obolibrary.org/obo/GO_0031340 GO:0031341 biolink:BiologicalProcess regulation of cell killing Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. go.json http://purl.obolibrary.org/obo/GO_0031341 GO:0031339 biolink:BiologicalProcess negative regulation of vesicle fusion Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. go.json down regulation of vesicle fusion|down-regulation of vesicle fusion|downregulation of vesicle fusion|inhibition of vesicle fusion http://purl.obolibrary.org/obo/GO_0031339 GO:0031337 biolink:BiologicalProcess positive regulation of sulfur amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. go.json activation of sulfur amino acid metabolic process|positive regulation of sulfur amino acid metabolism|stimulation of sulfur amino acid metabolic process|up regulation of sulfur amino acid metabolic process|up-regulation of sulfur amino acid metabolic process|upregulation of sulfur amino acid metabolic process http://purl.obolibrary.org/obo/GO_0031337 GO:0031338 biolink:BiologicalProcess regulation of vesicle fusion Any process that modulates the frequency, rate or extent of vesicle fusion. go.json http://purl.obolibrary.org/obo/GO_0031338 GO:0031335 biolink:BiologicalProcess regulation of sulfur amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. go.json regulation of sulfur amino acid metabolism http://purl.obolibrary.org/obo/GO_0031335 GO:0031336 biolink:BiologicalProcess negative regulation of sulfur amino acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. go.json down regulation of sulfur amino acid metabolic process|down-regulation of sulfur amino acid metabolic process|downregulation of sulfur amino acid metabolic process|inhibition of sulfur amino acid metabolic process|negative regulation of sulfur amino acid metabolism http://purl.obolibrary.org/obo/GO_0031336 GO:0006399 biolink:BiologicalProcess tRNA metabolic process The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. go.json tRNA metabolism http://purl.obolibrary.org/obo/GO_0006399 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pombe GO:0006397 biolink:BiologicalProcess mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. go.json mRNA maturation http://purl.obolibrary.org/obo/GO_0006397 goslim_chembl|goslim_yeast GO:0006398 biolink:BiologicalProcess mRNA 3'-end processing by stem-loop binding and cleavage Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine. go.json histone mRNA 3' end processing http://purl.obolibrary.org/obo/GO_0006398 GO:0006395 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006395 GO:0006396 biolink:BiologicalProcess RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. Wikipedia:Post-transcriptional_modification go.json http://purl.obolibrary.org/obo/GO_0006396 goslim_drosophila|goslim_pir GO:0006393 biolink:BiologicalProcess termination of mitochondrial transcription A transcription termination process that completes the production of a primary mitochondrial transcript. go.json RNA transcription termination from mitochondrial promoter|mitochondrial transcription termination http://purl.obolibrary.org/obo/GO_0006393 GO:0006394 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006394 GO:0070949 biolink:BiologicalProcess regulation of neutrophil mediated killing of symbiont cell Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil. go.json http://purl.obolibrary.org/obo/GO_0070949 GO:0070947 biolink:BiologicalProcess neutrophil-mediated killing of fungus The directed killing of a fungal cell by a neutrophil. go.json neutrophil mediated killing of fungus http://purl.obolibrary.org/obo/GO_0070947 GO:0070948 biolink:BiologicalProcess regulation of neutrophil mediated cytotoxicity Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil. go.json regulation of neutrophil mediated cell killing http://purl.obolibrary.org/obo/GO_0070948 GO:0070945 biolink:BiologicalProcess neutrophil-mediated killing of gram-negative bacterium The directed killing of a gram-negative bacterium by a neutrophil. go.json neutrophil mediated killing of gram-negative bacterium http://purl.obolibrary.org/obo/GO_0070945 GO:0070946 biolink:BiologicalProcess neutrophil-mediated killing of gram-positive bacterium The directed killing of a gram-positive bacterium by a neutrophil. go.json neutrophil mediated killing of gram-positive bacterium http://purl.obolibrary.org/obo/GO_0070946 GO:0070943 biolink:BiologicalProcess neutrophil-mediated killing of symbiont cell The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json neutrophil mediated killing of symbiont cell http://purl.obolibrary.org/obo/GO_0070943 GO:0070944 biolink:BiologicalProcess neutrophil-mediated killing of bacterium The directed killing of a bacterium by a neutrophil. go.json neutrophil mediated killing of bacterium http://purl.obolibrary.org/obo/GO_0070944 GO:0031333 biolink:BiologicalProcess negative regulation of protein-containing complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. go.json down regulation of protein complex assembly|down-regulation of protein complex assembly|downregulation of protein complex assembly|inhibition of protein complex assembly|negative regulation of protein complex assembly http://purl.obolibrary.org/obo/GO_0031333 GO:0070941 biolink:BiologicalProcess eisosome assembly The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane. go.json http://purl.obolibrary.org/obo/GO_0070941 GO:0031334 biolink:BiologicalProcess positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly. go.json activation of protein complex assembly|positive regulation of protein complex assembly|stimulation of protein complex assembly|up regulation of protein complex assembly|up-regulation of protein complex assembly|upregulation of protein complex assembly http://purl.obolibrary.org/obo/GO_0031334 GO:0070942 biolink:BiologicalProcess neutrophil mediated cytotoxicity The directed killing of a target cell by a neutrophil. go.json neutrophil mediated cell killing http://purl.obolibrary.org/obo/GO_0070942 GO:0031331 biolink:BiologicalProcess positive regulation of cellular catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. go.json activation of cellular catabolic process|positive regulation of cellular breakdown|positive regulation of cellular catabolism|positive regulation of cellular degradation|stimulation of cellular catabolic process|up regulation of cellular catabolic process|up-regulation of cellular catabolic process|upregulation of cellular catabolic process http://purl.obolibrary.org/obo/GO_0031331 GO:0070940 biolink:BiologicalProcess obsolete dephosphorylation of RNA polymerase II C-terminal domain OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. go.json CTD domain dephosphorylation of RNA polymerase II|generation of II(A) form of RNA polymerase II|generation of hypophosphorylated CTD of RNA polymerase II True http://purl.obolibrary.org/obo/GO_0070940 GO:0031332 biolink:CellularComponent RNAi effector complex Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. go.json http://purl.obolibrary.org/obo/GO_0031332 goslim_pir GO:0031330 biolink:BiologicalProcess negative regulation of cellular catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. go.json down regulation of cellular catabolic process|down-regulation of cellular catabolic process|downregulation of cellular catabolic process|inhibition of cellular catabolic process|negative regulation of cellular breakdown|negative regulation of cellular catabolism|negative regulation of cellular degradation http://purl.obolibrary.org/obo/GO_0031330 GO:0031328 biolink:BiologicalProcess positive regulation of cellular biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. go.json activation of cellular biosynthetic process|positive regulation of cellular anabolism|positive regulation of cellular biosynthesis|positive regulation of cellular formation|positive regulation of cellular synthesis|stimulation of cellular biosynthetic process|up regulation of cellular biosynthetic process|up-regulation of cellular biosynthetic process|upregulation of cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0031328 GO:0031329 biolink:BiologicalProcess regulation of cellular catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. go.json regulation of cellular breakdown|regulation of cellular catabolism|regulation of cellular degradation http://purl.obolibrary.org/obo/GO_0031329 GO:0031326 biolink:BiologicalProcess regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. go.json regulation of cellular anabolism|regulation of cellular biosynthesis|regulation of cellular formation|regulation of cellular synthesis http://purl.obolibrary.org/obo/GO_0031326 GO:0031327 biolink:BiologicalProcess negative regulation of cellular biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. go.json down regulation of cellular biosynthetic process|down-regulation of cellular biosynthetic process|downregulation of cellular biosynthetic process|inhibition of cellular biosynthetic process|negative regulation of cellular anabolism|negative regulation of cellular biosynthesis|negative regulation of cellular formation|negative regulation of cellular synthesis http://purl.obolibrary.org/obo/GO_0031327 GO:0031324 biolink:BiologicalProcess negative regulation of cellular metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. go.json down regulation of cellular metabolic process|down-regulation of cellular metabolic process|downregulation of cellular metabolic process|inhibition of cellular metabolic process|negative regulation of cellular metabolism http://purl.obolibrary.org/obo/GO_0031324 gocheck_do_not_annotate GO:0006368 biolink:BiologicalProcess transcription elongation by RNA polymerase II The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. go.json RNA elongation from Pol II promoter|RNA polymerase II transcription elongation factor activity|transcription elongation by RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006368 GO:0006369 biolink:BiologicalProcess termination of RNA polymerase II transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript. go.json RNA 3'-end formation by RNA polymerase II|RNA polymerase II transcription termination|RNA polymerase II transcription termination factor activity|transcription termination from Pol II promoter|transcription termination from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006369 GO:0031325 biolink:BiologicalProcess positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. go.json activation of cellular metabolic process|positive regulation of cellular metabolism|stimulation of cellular metabolic process|up regulation of cellular metabolic process|up-regulation of cellular metabolic process|upregulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0031325 gocheck_do_not_annotate GO:0006366 biolink:BiologicalProcess transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). go.json RNA polymerase II transcription factor activity|gene-specific transcription from RNA polymerase II promoter|general transcription from RNA polymerase II promoter|specific transcription from RNA polymerase II promoter|transcription from Pol II promoter|transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006366 goslim_yeast GO:0006367 biolink:BiologicalProcess transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. go.json transcription initiation from Pol II promoter|transcription initiation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006367 GO:0006364 biolink:BiologicalProcess rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. go.json 35S primary transcript processing http://purl.obolibrary.org/obo/GO_0006364 goslim_yeast GO:0006365 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006365 GO:0006362 biolink:BiologicalProcess transcription elongation by RNA polymerase I The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. go.json RNA elongation from Pol I promoter|RNA polymerase I transcription elongation factor activity|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript http://purl.obolibrary.org/obo/GO_0006362 GO:0006363 biolink:BiologicalProcess termination of RNA polymerase I transcription A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit. go.json RNA polymerase I transcription termination|RNA polymerase I transcription termination factor activity|termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript|transcription termination from Pol I promoter|transcription termination from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_0006363 GO:0006360 biolink:BiologicalProcess transcription by RNA polymerase I The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. go.json RNA polymerase I transcription factor activity|transcription from Pol I promoter|transcription from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_0006360 goslim_yeast GO:0006361 biolink:BiologicalProcess transcription initiation at RNA polymerase I promoter A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I. go.json transcription initiation from Pol I promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript http://purl.obolibrary.org/obo/GO_0006361 GO:0006370 biolink:BiologicalProcess 7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. go.json 5' end capping|5' mRNA capping|5'-end mRNA processing|5'-end processing|mRNA capping http://purl.obolibrary.org/obo/GO_0006370 GO:0070978 biolink:BiologicalProcess voltage-gated calcium channel complex assembly Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex. go.json http://purl.obolibrary.org/obo/GO_0070978 GO:0070979 biolink:BiologicalProcess protein K11-linked ubiquitination A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. go.json http://purl.obolibrary.org/obo/GO_0070979 GO:0070976 biolink:MolecularActivity TIR domain binding Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. go.json Toll-Interleukin receptor domain binding http://purl.obolibrary.org/obo/GO_0070976 goslim_chembl GO:0070977 biolink:BiologicalProcess bone maturation A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0070977 GO:0031322 biolink:BiologicalProcess ascospore-type prospore-specific spindle pole body remodeling A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP). go.json ascospore-type prospore-specific spindle pole body modification|ascospore-type prospore-specific spindle pole body remodelling|forespore specific spindle pole body remodeling|forespore-specific spindle pole body remodeling|prospore-specific spindle pole body remodeling|sporulation-specific spindle pole body remodeling http://purl.obolibrary.org/obo/GO_0031322 GO:0070974 biolink:MolecularActivity POU domain binding Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors. go.json http://purl.obolibrary.org/obo/GO_0070974 GO:0031323 biolink:BiologicalProcess regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. go.json regulation of cellular metabolism http://purl.obolibrary.org/obo/GO_0031323 gocheck_do_not_annotate GO:0070975 biolink:MolecularActivity FHA domain binding Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich. go.json Forkhead-associated domain binding http://purl.obolibrary.org/obo/GO_0070975 GO:0070972 biolink:BiologicalProcess protein localization to endoplasmic reticulum A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. go.json protein localisation in endoplasmic reticulum|protein localization in ER|protein localization in endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0070972 GO:0031320 biolink:MolecularActivity hexitol dehydrogenase activity Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor. go.json http://purl.obolibrary.org/obo/GO_0031320 GO:0070973 biolink:BiologicalProcess protein localization to endoplasmic reticulum exit site A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site. go.json protein localisation to endoplasmic reticulum exit site|protein localization to ER exit site http://purl.obolibrary.org/obo/GO_0070973 GO:0031321 biolink:BiologicalProcess ascospore-type prospore assembly During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane. go.json ascospore-type prospore formation|forespore formation http://purl.obolibrary.org/obo/GO_0031321 GO:0070970 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070970 GO:0070971 biolink:CellularComponent endoplasmic reticulum exit site An endoplasmic reticulum part at which COPII-coated vesicles are produced. NIF_Subcellular:sao124393998 go.json ER exit site|transitional ER http://purl.obolibrary.org/obo/GO_0070971 GO:0031319 biolink:BiologicalProcess detection of cAMP The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP. go.json 3',5'-cAMP detection|3',5'-cAMP sensing|cAMP detection|cAMP sensing|cyclic AMP detection|detection of 3',5' cAMP|detection of 3',5'-cAMP|detection of adenosine 3',5'-cyclophosphate|detection of cyclic AMP http://purl.obolibrary.org/obo/GO_0031319 GO:0031317 biolink:CellularComponent tripartite ATP-independent periplasmic transporter complex A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients. go.json TRAP transporter complex|TRAP-T transporter complex http://purl.obolibrary.org/obo/GO_0031317 GO:0021990 biolink:BiologicalProcess neural plate formation The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0021990 GO:0031318 biolink:BiologicalProcess detection of folic acid The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal. go.json detection of folate|folate detection|folate sensing|folic acid detection|folic acid sensing http://purl.obolibrary.org/obo/GO_0031318 GO:0021991 biolink:BiologicalProcess neural plate thickening The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode. go.json http://purl.obolibrary.org/obo/GO_0021991 GO:0031315 biolink:CellularComponent extrinsic component of mitochondrial outer membrane The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to mitochondrial outer membrane http://purl.obolibrary.org/obo/GO_0031315 GO:0021992 biolink:BiologicalProcess cell proliferation involved in neural plate elongation The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue. go.json http://purl.obolibrary.org/obo/GO_0021992 GO:0021993 biolink:BiologicalProcess initiation of neural tube closure The process in which closure points are established at multiple points and along the neural rostrocaudal axis. go.json http://purl.obolibrary.org/obo/GO_0021993 GO:0031316 biolink:CellularComponent extrinsic component of nuclear outer membrane The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to nuclear outer membrane http://purl.obolibrary.org/obo/GO_0031316 GO:0006379 biolink:BiologicalProcess obsolete mRNA cleavage OBSOLETE. Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. go.json cleavage stimulation factor activity True http://purl.obolibrary.org/obo/GO_0006379 GO:0031313 biolink:CellularComponent extrinsic component of endosome membrane The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to endosome membrane http://purl.obolibrary.org/obo/GO_0031313 GO:0021994 biolink:BiologicalProcess progression of neural tube closure The process in which the neural folds are fused extending from the initial closure points. go.json http://purl.obolibrary.org/obo/GO_0021994 GO:0031314 biolink:CellularComponent extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to mitochondrial inner membrane http://purl.obolibrary.org/obo/GO_0031314 GO:0021995 biolink:BiologicalProcess neuropore closure The process of joining together the neural folds at either end of the neural tube. go.json http://purl.obolibrary.org/obo/GO_0021995 GO:0006377 biolink:BiologicalProcess obsolete MATa1 (A1) pre-mRNA splicing OBSOLETE. (Was not defined before being made obsolete). go.json MATa1 (A1) pre-mRNA splicing True http://purl.obolibrary.org/obo/GO_0006377 GO:0006378 biolink:BiologicalProcess mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. go.json http://purl.obolibrary.org/obo/GO_0006378 GO:0006375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006375 GO:0006376 biolink:BiologicalProcess mRNA splice site recognition Selection of a splice site by components of the assembling spliceosome. go.json spliceosomal E complex biosynthesis|spliceosomal E complex formation|spliceosomal commitment complex biosynthesis|spliceosomal commitment complex formation http://purl.obolibrary.org/obo/GO_0006376 GO:0006373 biolink:BiologicalProcess obsolete 3'-splice site cleavage, exon ligation OBSOLETE. (Was not defined before being made obsolete). go.json 3'-splice site cleavage, exon ligation True http://purl.obolibrary.org/obo/GO_0006373 GO:0006374 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006374 GO:0006371 biolink:BiologicalProcess obsolete mRNA splicing OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced. go.json mRNA splicing True http://purl.obolibrary.org/obo/GO_0006371 GO:0006372 biolink:BiologicalProcess obsolete lariat formation, 5'-splice site cleavage OBSOLETE. (Was not defined before being made obsolete). go.json lariat formation, 5'-splice site cleavage True http://purl.obolibrary.org/obo/GO_0006372 GO:0006380 biolink:BiologicalProcess obsolete poly-A binding OBSOLETE. (Was not defined before being made obsolete). go.json poly-A binding True http://purl.obolibrary.org/obo/GO_0006380 GO:0006381 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006381 GO:0070969 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070969 GO:0070967 biolink:MolecularActivity coenzyme F420 binding Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. go.json http://purl.obolibrary.org/obo/GO_0070967 GO:0070968 biolink:MolecularActivity pyrroloquinoline quinone binding Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases. go.json PQQ binding http://purl.obolibrary.org/obo/GO_0070968 GO:0070965 biolink:BiologicalProcess positive regulation of neutrophil mediated killing of fungus Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil. go.json activation of neutrophil mediated killing of fungus|stimulation of neutrophil mediated killing of fungus|up regulation of neutrophil mediated killing of fungus|up-regulation of neutrophil mediated killing of fungus|upregulation of neutrophil mediated killing of fungus http://purl.obolibrary.org/obo/GO_0070965 GO:0070966 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, no-go decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation. go.json no-go decay|no-go mRNA decay|nuclear-transcribed mRNA breakdown, no-go decay|nuclear-transcribed mRNA catabolism, no-go decay|nuclear-transcribed mRNA degradation, no-go decay http://purl.obolibrary.org/obo/GO_0070966 GO:0070963 biolink:BiologicalProcess positive regulation of neutrophil mediated killing of gram-negative bacterium Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil. go.json activation of neutrophil mediated killing of gram-negative bacterium|stimulation of neutrophil mediated killing of gram-negative bacterium|up regulation of neutrophil mediated killing of gram-negative bacterium|up-regulation of neutrophil mediated killing of gram-negative bacterium|upregulation of neutrophil mediated killing of gram-negative bacterium http://purl.obolibrary.org/obo/GO_0070963 GO:0031311 biolink:CellularComponent obsolete intrinsic component of contractile vacuolar membrane OBSOLETE. The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to contractile vacuolar membrane True http://purl.obolibrary.org/obo/GO_0031311 GO:0021996 biolink:BiologicalProcess lamina terminalis formation The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore. go.json http://purl.obolibrary.org/obo/GO_0021996 GO:0070964 biolink:BiologicalProcess positive regulation of neutrophil mediated killing of gram-positive bacterium Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil. go.json activation of neutrophil mediated killing of gram-positive bacterium|stimulation of neutrophil mediated killing of gram-positive bacterium|up regulation of neutrophil mediated killing of gram-positive bacterium|up-regulation of neutrophil mediated killing of gram-positive bacterium|upregulation of neutrophil mediated killing of gram-positive bacterium http://purl.obolibrary.org/obo/GO_0070964 GO:0031312 biolink:CellularComponent extrinsic component of organelle membrane The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to organelle membrane http://purl.obolibrary.org/obo/GO_0031312 GO:0021997 biolink:BiologicalProcess neural plate axis specification The pattern specification process in which the axes of the nervous system are established. go.json neural plate axis determination http://purl.obolibrary.org/obo/GO_0021997 GO:0070961 biolink:BiologicalProcess positive regulation of neutrophil mediated killing of symbiont cell Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil. go.json activation of neutrophil mediated killing of symbiont cell|stimulation of neutrophil mediated killing of symbiont cell|up regulation of neutrophil mediated killing of symbiont cell|up-regulation of neutrophil mediated killing of symbiont cell|upregulation of neutrophil mediated killing of symbiont cell http://purl.obolibrary.org/obo/GO_0070961 GO:0021998 biolink:BiologicalProcess neural plate mediolateral regionalization The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate. go.json neural plate mediolateral pattern formation http://purl.obolibrary.org/obo/GO_0021998 GO:0070962 biolink:BiologicalProcess positive regulation of neutrophil mediated killing of bacterium Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil. go.json activation of neutrophil mediated killing of bacterium|stimulation of neutrophil mediated killing of bacterium|up regulation of neutrophil mediated killing of bacterium|up-regulation of neutrophil mediated killing of bacterium|upregulation of neutrophil mediated killing of bacterium http://purl.obolibrary.org/obo/GO_0070962 GO:0031310 biolink:CellularComponent obsolete intrinsic component of vacuolar membrane OBSOLETE. The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to vacuolar membrane True http://purl.obolibrary.org/obo/GO_0031310 GO:0021999 biolink:BiologicalProcess neural plate anterior/posterior regionalization The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. go.json neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0021999 GO:0070960 biolink:BiologicalProcess positive regulation of neutrophil mediated cytotoxicity Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil. go.json activation of neutrophil mediated cytotoxicity|positive regulation of neutrophil mediated cell killing|stimulation of neutrophil mediated cytotoxicity|up regulation of neutrophil mediated cytotoxicity|up-regulation of neutrophil mediated cytotoxicity|upregulation of neutrophil mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0070960 GO:0031308 biolink:CellularComponent obsolete intrinsic component of nuclear outer membrane OBSOLETE. The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to nuclear outer membrane True http://purl.obolibrary.org/obo/GO_0031308 GO:0031309 biolink:CellularComponent obsolete integral component of nuclear outer membrane OBSOLETE. The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to nuclear outer membrane True http://purl.obolibrary.org/obo/GO_0031309 GO:0031306 biolink:CellularComponent obsolete intrinsic component of mitochondrial outer membrane OBSOLETE. The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to mitochondrial outer membrane True http://purl.obolibrary.org/obo/GO_0031306 GO:0021980 biolink:BiologicalProcess subpallium cell migration The orderly movement of cells from one site to another in the subpallium. go.json http://purl.obolibrary.org/obo/GO_0021980 GO:0031307 biolink:CellularComponent obsolete integral component of mitochondrial outer membrane OBSOLETE. The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to mitochondrial outer membrane True http://purl.obolibrary.org/obo/GO_0031307 GO:0006348 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006348 GO:0021981 biolink:BiologicalProcess subpallium radially oriented migration The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. go.json http://purl.obolibrary.org/obo/GO_0021981 GO:0031304 biolink:CellularComponent obsolete intrinsic component of mitochondrial inner membrane OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to mitochondrial inner membrane True http://purl.obolibrary.org/obo/GO_0031304 GO:0006349 biolink:BiologicalProcess obsolete regulation of gene expression by genomic imprinting OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles. go.json regulation of gene expression by DNA imprinting|regulation of gene expression by genetic imprinting True http://purl.obolibrary.org/obo/GO_0006349 GO:0021982 biolink:BiologicalProcess pineal gland development The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms. go.json epiphysis development http://purl.obolibrary.org/obo/GO_0021982 GO:0031305 biolink:CellularComponent obsolete integral component of mitochondrial inner membrane OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to mitochondrial inner membrane True http://purl.obolibrary.org/obo/GO_0031305 GO:0031302 biolink:CellularComponent obsolete intrinsic component of endosome membrane OBSOLETE. The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to endosome membrane True http://purl.obolibrary.org/obo/GO_0031302 GO:0006346 biolink:BiologicalProcess DNA methylation-dependent heterochromatin formation Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. go.json DNA methylation-dependent heterochromatin assembly|methylation-dependent chromatin silencing|methylation-dependent heterochromatic silencing http://purl.obolibrary.org/obo/GO_0006346 GO:0021983 biolink:BiologicalProcess pituitary gland development The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. go.json hypophysis development http://purl.obolibrary.org/obo/GO_0021983 GO:0031303 biolink:CellularComponent obsolete integral component of endosome membrane OBSOLETE. The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to endosome membrane True http://purl.obolibrary.org/obo/GO_0031303 GO:0006347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006347 GO:0021984 biolink:BiologicalProcess adenohypophysis development The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. go.json adenophysis development|anterior pituitary development|anterior pituitary gland development http://purl.obolibrary.org/obo/GO_0021984 GO:0006344 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006344 GO:0006345 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006345 GO:0006342 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006342 GO:0006343 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006343 GO:0006340 biolink:BiologicalProcess obsolete negative regulation of transcription of homeotic gene (Polycomb group) OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group. go.json negative regulation of transcription of homeotic gene (Polycomb group) True http://purl.obolibrary.org/obo/GO_0006340 GO:0006341 biolink:BiologicalProcess obsolete chromatin insulator sequence binding OBSOLETE. (Was not defined before being made obsolete). go.json chromatin insulator sequence binding True http://purl.obolibrary.org/obo/GO_0006341 GO:0070998 biolink:BiologicalProcess sensory perception of gravity The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json http://purl.obolibrary.org/obo/GO_0070998 GO:0070999 biolink:BiologicalProcess detection of mechanical stimulus involved in sensory perception of gravity The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0070999 GO:0021985 biolink:BiologicalProcess neurohypophysis development The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. go.json neurophysis development|posterior pituitary development|posterior pituitary gland development http://purl.obolibrary.org/obo/GO_0021985 GO:0031300 biolink:CellularComponent obsolete intrinsic component of organelle membrane OBSOLETE. The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to organelle membrane True http://purl.obolibrary.org/obo/GO_0031300 GO:0070996 biolink:MolecularActivity type 1 melanocortin receptor binding Binding to a type 1 melanocortin receptor. go.json type 1 melanocortin receptor ligand http://purl.obolibrary.org/obo/GO_0070996 GO:0070997 biolink:BiologicalProcess obsolete neuron death OBSOLETE. The process of cell death in a neuron. go.json neuron cell death|neuronal cell death True http://purl.obolibrary.org/obo/GO_0070997 GO:0031301 biolink:CellularComponent obsolete integral component of organelle membrane OBSOLETE. The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to organelle membrane True http://purl.obolibrary.org/obo/GO_0031301 GO:0021986 biolink:BiologicalProcess habenula development The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland. go.json http://purl.obolibrary.org/obo/GO_0021986 GO:0021987 biolink:BiologicalProcess cerebral cortex development The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. go.json corticogenesis|neocortex development http://purl.obolibrary.org/obo/GO_0021987 GO:0070994 biolink:BiologicalProcess detection of oxidative stress The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0070994 GO:0070995 biolink:BiologicalProcess NADPH oxidation A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP. go.json NADP (reduced) dehydrogenation|NADP (reduced) oxidation|NADPH dehydrogenation|reduced NADP dehydrogenation|reduced NADP oxidation|reduced nicotinamide adenine dinucleotide phosphate dehydrogenation|reduced nicotinamide adenine dinucleotide phosphate oxidation http://purl.obolibrary.org/obo/GO_0070995 GO:0021988 biolink:BiologicalProcess olfactory lobe development The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. go.json http://purl.obolibrary.org/obo/GO_0021988 GO:0070992 biolink:CellularComponent translation initiation complex A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. go.json http://purl.obolibrary.org/obo/GO_0070992 GO:0021989 biolink:BiologicalProcess olfactory cortex development The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors. go.json http://purl.obolibrary.org/obo/GO_0021989 GO:0070993 biolink:CellularComponent translation preinitiation complex A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. go.json http://purl.obolibrary.org/obo/GO_0070993 GO:0070990 biolink:MolecularActivity snRNP binding Binding to a small nuclear ribonucleoprotein particle. go.json http://purl.obolibrary.org/obo/GO_0070990 GO:0070991 biolink:MolecularActivity medium-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. EC:1.3.8.7|RHEA:14477 go.json MCAD activity http://purl.obolibrary.org/obo/GO_0070991 GO:0006359 biolink:BiologicalProcess regulation of transcription by RNA polymerase III Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III. go.json regulation of transcription from Pol III promoter|regulation of transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0006359 GO:0021970 biolink:BiologicalProcess corticospinal neuron axon guidance through the basilar pons The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding through the basilar pons http://purl.obolibrary.org/obo/GO_0021970 GO:0021971 biolink:BiologicalProcess corticospinal neuron axon guidance through the medullary pyramid The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding through the medullary pyramid http://purl.obolibrary.org/obo/GO_0021971 GO:0021972 biolink:BiologicalProcess corticospinal neuron axon guidance through spinal cord The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding through spinal cord http://purl.obolibrary.org/obo/GO_0021972 GO:0006357 biolink:BiologicalProcess regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. go.json global transcription regulation from Pol II promoter|regulation of gene-specific transcription from RNA polymerase II promoter|regulation of global transcription from Pol II promoter|regulation of transcription from Pol II promoter|regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter, global http://purl.obolibrary.org/obo/GO_0006357 GO:0021973 biolink:BiologicalProcess corticospinal neuron axon decussation The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side. go.json http://purl.obolibrary.org/obo/GO_0021973 GO:0006358 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006358 GO:0006355 biolink:BiologicalProcess regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. go.json regulation of cellular transcription, DNA-dependent|regulation of gene-specific transcription|regulation of transcription, DNA-dependent|regulation of transcription, DNA-templated|transcriptional control http://purl.obolibrary.org/obo/GO_0006355 goslim_drosophila|goslim_generic|prokaryote_subset GO:0006356 biolink:BiologicalProcess regulation of transcription by RNA polymerase I Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I. go.json regulation of transcription from Pol I promoter|regulation of transcription from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_0006356 GO:0006353 biolink:BiologicalProcess DNA-templated transcription termination The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. go.json DNA-dependent transcription, termination|DNA-templated transcription, termination|termination of DNA-dependent transcription|termination of transcription, DNA-dependent|transcription termination factor activity|transcription termination from bacterial-type RNA polymerase promoter|transcription termination, DNA-dependent|transcriptional complex disassembly http://purl.obolibrary.org/obo/GO_0006353 goslim_yeast GO:0006354 biolink:BiologicalProcess DNA-templated transcription elongation The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. go.json DNA-dependent transcription, elongation|DNA-templated transcription, elongation|RNA elongation|RNA elongation from bacterial-type RNA polymerase promoter|transcription elongation from bacterial-type RNA polymerase promoter|transcription elongation, DNA-dependent|transcriptional elongation, DNA-dependent http://purl.obolibrary.org/obo/GO_0006354 goslim_pir|goslim_yeast GO:0006351 biolink:BiologicalProcess DNA-templated transcription The synthesis of an RNA transcript from a DNA template. Wikipedia:Transcription_(genetics) go.json DNA-dependent transcription|bacterial transcription|cellular transcription|transcription|transcription from bacterial-type RNA polymerase promoter|transcription, DNA-dependent|transcription, DNA-templated http://purl.obolibrary.org/obo/GO_0006351 goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_pombe|prokaryote_subset GO:0006352 biolink:BiologicalProcess DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. go.json DNA-dependent RNA polymerase complex assembly at promoter|DNA-dependent transcription, initiation|DNA-templated transcription, initiation|initiation of DNA-dependent transcription|initiation of transcription, DNA-dependent|transcription initiation factor activity|transcription initiation from bacterial-type RNA polymerase promoter|transcription initiation, DNA-dependent http://purl.obolibrary.org/obo/GO_0006352 goslim_yeast GO:0006350 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006350 GO:0070989 biolink:BiologicalProcess oxidative demethylation The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. go.json http://purl.obolibrary.org/obo/GO_0070989 goslim_chembl GO:0070987 biolink:BiologicalProcess error-free translesion synthesis The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. go.json http://purl.obolibrary.org/obo/GO_0070987 GO:0070988 biolink:BiologicalProcess demethylation The process of removing one or more methyl groups from a molecule. go.json http://purl.obolibrary.org/obo/GO_0070988 GO:0070985 biolink:CellularComponent transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. go.json Mcs6/Mcs2/Pmh1 complex|TFIIK complex|cyclin H-CDK7 complex http://purl.obolibrary.org/obo/GO_0070985 GO:0021974 biolink:BiologicalProcess trigeminothalamic tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face. go.json http://purl.obolibrary.org/obo/GO_0021974 GO:0070986 biolink:BiologicalProcess left/right axis specification The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). go.json left-right axis specification|left/right axis determination http://purl.obolibrary.org/obo/GO_0070986 GO:0021975 biolink:BiologicalProcess pons reticulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021975 GO:0021976 biolink:BiologicalProcess medulla reticulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021976 GO:0070983 biolink:BiologicalProcess dendrite guidance The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues. go.json dendritic guidance http://purl.obolibrary.org/obo/GO_0070983 GO:0021977 biolink:BiologicalProcess tectospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021977 GO:0070984 biolink:MolecularActivity SET domain binding Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation. go.json SET binding http://purl.obolibrary.org/obo/GO_0070984 GO:0021978 biolink:BiologicalProcess telencephalon regionalization The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. go.json http://purl.obolibrary.org/obo/GO_0021978 GO:0070981 biolink:BiologicalProcess L-asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid. go.json L-asparagine anabolism|L-asparagine biosynthesis|L-asparagine formation|L-asparagine synthesis http://purl.obolibrary.org/obo/GO_0070981 GO:0021979 biolink:BiologicalProcess hypothalamus cell differentiation The differentiation of cells that will contribute to the structure and function of the hypothalamus. go.json http://purl.obolibrary.org/obo/GO_0021979 GO:0070982 biolink:BiologicalProcess L-asparagine metabolic process The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid. go.json L-asparagine metabolism http://purl.obolibrary.org/obo/GO_0070982 GO:0070980 biolink:BiologicalProcess biphenyl catabolic process The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). go.json biphenyl breakdown|biphenyl catabolism|biphenyl degradation http://purl.obolibrary.org/obo/GO_0070980 GO:0006328 biolink:BiologicalProcess obsolete AT binding OBSOLETE. (Was not defined before being made obsolete). go.json AT binding True http://purl.obolibrary.org/obo/GO_0006328 GO:0006329 biolink:BiologicalProcess obsolete satellite DNA binding OBSOLETE. (Was not defined before being made obsolete). go.json satellite DNA binding True http://purl.obolibrary.org/obo/GO_0006329 GO:0006326 biolink:BiologicalProcess obsolete bent DNA binding OBSOLETE. (Was not defined before being made obsolete). go.json bent DNA binding True http://purl.obolibrary.org/obo/GO_0006326 GO:0021960 biolink:BiologicalProcess anterior commissure morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. go.json http://purl.obolibrary.org/obo/GO_0021960 GO:0006327 biolink:BiologicalProcess obsolete random coil binding OBSOLETE. (Was not defined before being made obsolete). go.json random coil binding True http://purl.obolibrary.org/obo/GO_0006327 GO:0006324 biolink:BiologicalProcess obsolete S phase-specific histone modification OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle. go.json S phase-specific histone modification|S-phase-specific histone modification True http://purl.obolibrary.org/obo/GO_0006324 GO:0021961 biolink:BiologicalProcess posterior commissure morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon. go.json http://purl.obolibrary.org/obo/GO_0021961 GO:0006325 biolink:BiologicalProcess chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. go.json DNA replication-independent chromatin assembly|DNA replication-independent chromatin organization|DNA replication-independent nucleosome organisation|DNA replication-independent nuclesome assembly|chromatin assembly|chromatin assembly or disassembly|chromatin assembly/disassembly|chromatin maintenance|chromatin modification|chromatin organisation|establishment of chromatin architecture|establishment or maintenance of chromatin architecture|transcription-coupled nucleosome assembly http://purl.obolibrary.org/obo/GO_0006325 goslim_generic|goslim_pombe|goslim_yeast GO:0021962 biolink:BiologicalProcess vestibulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021962 GO:0006322 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006322 GO:0006323 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006323 GO:0006320 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006320 GO:0006321 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006321 GO:0021963 biolink:BiologicalProcess spinothalamic tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling. go.json dorsolateral tract of Lissauer morphogenesis http://purl.obolibrary.org/obo/GO_0021963 GO:0021964 biolink:BiologicalProcess rubrospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021964 GO:0021965 biolink:BiologicalProcess spinal cord ventral commissure morphogenesis The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0021965 GO:0021966 biolink:BiologicalProcess corticospinal neuron axon guidance The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding http://purl.obolibrary.org/obo/GO_0021966 GO:0021967 biolink:BiologicalProcess corticospinal neuron axon guidance through the cerebral cortex The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding through the cerebral cortex http://purl.obolibrary.org/obo/GO_0021967 GO:0021968 biolink:BiologicalProcess corticospinal neuron axon guidance through the internal capsule The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding through the internal capsule http://purl.obolibrary.org/obo/GO_0021968 GO:0021969 biolink:BiologicalProcess corticospinal neuron axon guidance through the cerebral peduncle The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues. go.json corticospinal neuron axon pathfinding through the cerebral peduncle http://purl.obolibrary.org/obo/GO_0021969 GO:0006339 biolink:BiologicalProcess obsolete positive regulation of transcription of homeotic gene (trithorax group) OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group. go.json positive regulation of transcription of homeotic gene (trithorax group) True http://purl.obolibrary.org/obo/GO_0006339 GO:0006337 biolink:BiologicalProcess nucleosome disassembly The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. go.json http://purl.obolibrary.org/obo/GO_0006337 GO:0006338 biolink:BiologicalProcess chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. go.json ATP-dependent chromatin remodeling|ATP-dependent chromatin remodelling|chromatin modeling|chromatin modelling|chromatin remodelling http://purl.obolibrary.org/obo/GO_0006338 GO:0006335 biolink:BiologicalProcess DNA replication-dependent chromatin assembly The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation. go.json DNA replication-dependent chromatin organization|DNA replication-dependent nucleosome assembly|DNA replication-dependent nucleosome organisation|DNA replication-dependent nucleosome organization http://purl.obolibrary.org/obo/GO_0006335 GO:0021950 biolink:BiologicalProcess chemorepulsion involved in precerebellar neuron migration The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration. go.json negative chemotaxis involved in precerebellar neuron migration http://purl.obolibrary.org/obo/GO_0021950 GO:0021951 biolink:BiologicalProcess chemoattraction involved in precerebellar neuron migration The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration. go.json positive chemotaxis involved in precerebellar neuron migration http://purl.obolibrary.org/obo/GO_0021951 GO:0006336 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006336 GO:0006333 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006333 GO:0006334 biolink:BiologicalProcess nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. go.json histone chaperone|nucleosome modeling http://purl.obolibrary.org/obo/GO_0006334 GO:0006331 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006331 GO:0006332 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006332 GO:0006330 biolink:BiologicalProcess obsolete single-stranded DNA binding OBSOLETE. (Was not defined before being made obsolete). go.json single-stranded DNA binding True http://purl.obolibrary.org/obo/GO_0006330 GO:0021952 biolink:BiologicalProcess central nervous system projection neuron axonogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. go.json central nervous system axon tract development http://purl.obolibrary.org/obo/GO_0021952 GO:0021953 biolink:BiologicalProcess central nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0021953 GO:0021954 biolink:BiologicalProcess central nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. go.json http://purl.obolibrary.org/obo/GO_0021954 GO:0021955 biolink:BiologicalProcess central nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. go.json http://purl.obolibrary.org/obo/GO_0021955 GO:0021956 biolink:BiologicalProcess central nervous system interneuron axonogenesis Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region. go.json http://purl.obolibrary.org/obo/GO_0021956 GO:0021957 biolink:BiologicalProcess corticospinal tract morphogenesis Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract. go.json CST axonogenesis|corticospinal tract axonogenesis http://purl.obolibrary.org/obo/GO_0021957 GO:0021958 biolink:BiologicalProcess gracilis tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb. go.json tract of Goll morphogenesis http://purl.obolibrary.org/obo/GO_0021958 GO:0021959 biolink:BiologicalProcess cuneatus tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb. go.json tract of Burdach morphogenesis http://purl.obolibrary.org/obo/GO_0021959 GO:0045916 biolink:BiologicalProcess negative regulation of complement activation Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation. go.json down regulation of complement activation|down-regulation of complement activation|downregulation of complement activation|inhibition of complement activation|negative regulation of complement cascade http://purl.obolibrary.org/obo/GO_0045916 GO:0045917 biolink:BiologicalProcess positive regulation of complement activation Any process that activates or increases the frequency, rate or extent of complement activation. go.json activation of complement activation|positive regulation of complement cascade|stimulation of complement activation|up regulation of complement activation|up-regulation of complement activation|upregulation of complement activation http://purl.obolibrary.org/obo/GO_0045917 GO:0045914 biolink:BiologicalProcess negative regulation of catecholamine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. go.json down regulation of catecholamine metabolic process|down-regulation of catecholamine metabolic process|downregulation of catecholamine metabolic process|inhibition of catecholamine metabolic process|negative regulation of catecholamine metabolism http://purl.obolibrary.org/obo/GO_0045914 GO:0045915 biolink:BiologicalProcess positive regulation of catecholamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. go.json activation of catecholamine metabolic process|positive regulation of catecholamine metabolism|stimulation of catecholamine metabolic process|up regulation of catecholamine metabolic process|up-regulation of catecholamine metabolic process|upregulation of catecholamine metabolic process http://purl.obolibrary.org/obo/GO_0045915 GO:0045912 biolink:BiologicalProcess negative regulation of carbohydrate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. go.json down regulation of carbohydrate metabolic process|down-regulation of carbohydrate metabolic process|downregulation of carbohydrate metabolic process|inhibition of carbohydrate metabolic process|negative regulation of carbohydrate metabolism http://purl.obolibrary.org/obo/GO_0045912 GO:0045913 biolink:BiologicalProcess positive regulation of carbohydrate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. go.json activation of carbohydrate metabolic process|positive regulation of carbohydrate metabolism|stimulation of carbohydrate metabolic process|up regulation of carbohydrate metabolic process|up-regulation of carbohydrate metabolic process|upregulation of carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0045913 GO:0045910 biolink:BiologicalProcess negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. go.json down regulation of DNA recombination|down-regulation of DNA recombination|downregulation of DNA recombination|inhibition of DNA recombination http://purl.obolibrary.org/obo/GO_0045910 GO:0045911 biolink:BiologicalProcess positive regulation of DNA recombination Any process that activates or increases the frequency, rate or extent of DNA recombination. go.json activation of DNA recombination|stimulation of DNA recombination|up regulation of DNA recombination|up-regulation of DNA recombination|upregulation of DNA recombination http://purl.obolibrary.org/obo/GO_0045911 GO:0045918 biolink:BiologicalProcess negative regulation of cytolysis Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis. go.json down regulation of cytolysis|down-regulation of cytolysis|downregulation of cytolysis|inhibition of cytolysis http://purl.obolibrary.org/obo/GO_0045918 GO:0045919 biolink:BiologicalProcess positive regulation of cytolysis Any process that activates or increases the frequency, rate or extent of cytolysis. go.json activation of cytolysis|stimulation of cytolysis|up regulation of cytolysis|up-regulation of cytolysis|upregulation of cytolysis http://purl.obolibrary.org/obo/GO_0045919 GO:0045920 biolink:BiologicalProcess negative regulation of exocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. go.json down regulation of exocytosis|down-regulation of exocytosis|downregulation of exocytosis|inhibition of exocytosis http://purl.obolibrary.org/obo/GO_0045920 GO:0045927 biolink:BiologicalProcess positive regulation of growth Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. go.json activation of growth|stimulation of growth|up regulation of growth|up-regulation of growth|upregulation of growth http://purl.obolibrary.org/obo/GO_0045927 GO:0045928 biolink:BiologicalProcess negative regulation of juvenile hormone metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. go.json down regulation of juvenile hormone metabolic process|down-regulation of juvenile hormone metabolic process|downregulation of juvenile hormone metabolic process|inhibition of juvenile hormone metabolic process|negative regulation of juvenile hormone metabolism http://purl.obolibrary.org/obo/GO_0045928 GO:0045925 biolink:BiologicalProcess positive regulation of female receptivity Any process that activates or increases the receptiveness of a female to male advances. go.json activation of female receptivity|stimulation of female receptivity|up regulation of female receptivity|up-regulation of female receptivity|upregulation of female receptivity http://purl.obolibrary.org/obo/GO_0045925 GO:0045926 biolink:BiologicalProcess negative regulation of growth Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. go.json down regulation of growth|down-regulation of growth|downregulation of growth|inhibition of growth http://purl.obolibrary.org/obo/GO_0045926 GO:0045923 biolink:BiologicalProcess positive regulation of fatty acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. go.json activation of fatty acid metabolic process|positive regulation of fatty acid metabolism|stimulation of fatty acid metabolic process|up regulation of fatty acid metabolic process|up-regulation of fatty acid metabolic process|upregulation of fatty acid metabolic process http://purl.obolibrary.org/obo/GO_0045923 GO:0045924 biolink:BiologicalProcess regulation of female receptivity Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances. go.json female receptivity http://purl.obolibrary.org/obo/GO_0045924 GO:0045921 biolink:BiologicalProcess positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis. go.json activation of exocytosis|stimulation of exocytosis|up regulation of exocytosis|up-regulation of exocytosis|upregulation of exocytosis http://purl.obolibrary.org/obo/GO_0045921 GO:0045922 biolink:BiologicalProcess negative regulation of fatty acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. go.json down regulation of fatty acid metabolic process|down-regulation of fatty acid metabolic process|downregulation of fatty acid metabolic process|inhibition of fatty acid metabolic process|negative regulation of fatty acid metabolism http://purl.obolibrary.org/obo/GO_0045922 GO:0045929 biolink:BiologicalProcess positive regulation of juvenile hormone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. go.json activation of juvenile hormone metabolic process|positive regulation of juvenile hormone metabolism|stimulation of juvenile hormone metabolic process|up regulation of juvenile hormone metabolic process|up-regulation of juvenile hormone metabolic process|upregulation of juvenile hormone metabolic process http://purl.obolibrary.org/obo/GO_0045929 GO:0045930 biolink:BiologicalProcess negative regulation of mitotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. go.json down regulation of progression through mitotic cell cycle|down-regulation of progression through mitotic cell cycle|downregulation of progression through mitotic cell cycle|inhibition of progression through mitotic cell cycle|negative regulation of mitotic cell cycle progression|negative regulation of progression through mitotic cell cycle http://purl.obolibrary.org/obo/GO_0045930 GO:0045931 biolink:BiologicalProcess positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. go.json activation of progression through mitotic cell cycle|positive regulation of mitotic cell cycle progression|positive regulation of progression through mitotic cell cycle|stimulation of progression through mitotic cell cycle|up regulation of progression through mitotic cell cycle|up-regulation of progression through mitotic cell cycle|upregulation of progression through mitotic cell cycle http://purl.obolibrary.org/obo/GO_0045931 GO:0045938 biolink:BiologicalProcess positive regulation of circadian sleep/wake cycle, sleep Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. go.json activation of circadian sleep/wake cycle, sleep|positive regulation of sleep|stimulation of circadian sleep/wake cycle, sleep|up regulation of circadian sleep/wake cycle, sleep|up-regulation of circadian sleep/wake cycle, sleep|upregulation of circadian sleep/wake cycle, sleep http://purl.obolibrary.org/obo/GO_0045938 GO:0045939 biolink:BiologicalProcess negative regulation of steroid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. go.json down regulation of steroid metabolic process|down-regulation of steroid metabolic process|downregulation of steroid metabolic process|inhibition of steroid metabolic process|negative regulation of steroid metabolism http://purl.obolibrary.org/obo/GO_0045939 GO:0045936 biolink:BiologicalProcess negative regulation of phosphate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. go.json down regulation of phosphate metabolic process|down-regulation of phosphate metabolic process|downregulation of phosphate metabolic process|inhibition of phosphate metabolic process|negative regulation of phosphate metabolism http://purl.obolibrary.org/obo/GO_0045936 GO:0045937 biolink:BiologicalProcess positive regulation of phosphate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. go.json activation of phosphate metabolic process|positive regulation of phosphate metabolism|stimulation of phosphate metabolic process|up regulation of phosphate metabolic process|up-regulation of phosphate metabolic process|upregulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0045937 GO:0045934 biolink:BiologicalProcess negative regulation of nucleobase-containing compound metabolic process Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. go.json down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism http://purl.obolibrary.org/obo/GO_0045934 GO:0045935 biolink:BiologicalProcess positive regulation of nucleobase-containing compound metabolic process Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. go.json activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism|stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0045935 GO:0045932 biolink:BiologicalProcess negative regulation of muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. go.json down regulation of muscle contraction|down-regulation of muscle contraction|downregulation of muscle contraction|inhibition of muscle contraction http://purl.obolibrary.org/obo/GO_0045932 GO:0045933 biolink:BiologicalProcess positive regulation of muscle contraction Any process that activates or increases the frequency, rate or extent of muscle contraction. go.json activation of muscle contraction|stimulation of muscle contraction|up regulation of muscle contraction|up-regulation of muscle contraction|upregulation of muscle contraction http://purl.obolibrary.org/obo/GO_0045933 GO:0045941 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045941 GO:0045942 biolink:BiologicalProcess negative regulation of phosphorus utilization Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization. go.json down regulation of phosphorus utilization|down-regulation of phosphorus utilization|downregulation of phosphorus utilization|inhibition of phosphorus utilization http://purl.obolibrary.org/obo/GO_0045942 GO:0045940 biolink:BiologicalProcess positive regulation of steroid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. go.json activation of steroid metabolic process|positive regulation of steroid metabolism|stimulation of steroid metabolic process|up regulation of steroid metabolic process|up-regulation of steroid metabolic process|upregulation of steroid metabolic process http://purl.obolibrary.org/obo/GO_0045940 GO:0031391 biolink:CellularComponent Elg1 RFC-like complex A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. go.json Elg1-RFC|Elg1-RLC|RFC (Elg1) http://purl.obolibrary.org/obo/GO_0031391 GO:0045949 biolink:BiologicalProcess positive regulation of phosphorus utilization Any process that activates or increases the frequency, rate or extent of phosphorus utilization. go.json activation of phosphorus utilization|stimulation of phosphorus utilization|up regulation of phosphorus utilization|up-regulation of phosphorus utilization|upregulation of phosphorus utilization http://purl.obolibrary.org/obo/GO_0045949 GO:0031392 biolink:BiologicalProcess regulation of prostaglandin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. go.json regulation of prostaglandin anabolism|regulation of prostaglandin biosynthesis|regulation of prostaglandin formation|regulation of prostaglandin synthesis http://purl.obolibrary.org/obo/GO_0031392 GO:0045947 biolink:BiologicalProcess negative regulation of translational initiation Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. go.json down regulation of translational initiation|down-regulation of translational initiation|downregulation of translational initiation|inhibition of translational initiation http://purl.obolibrary.org/obo/GO_0045947 GO:0045948 biolink:BiologicalProcess positive regulation of translational initiation Any process that activates or increases the frequency, rate or extent of translational initiation. go.json activation of translational initiation|stimulation of translational initiation|up regulation of translational initiation|up-regulation of translational initiation|upregulation of translational initiation http://purl.obolibrary.org/obo/GO_0045948 GO:0031390 biolink:CellularComponent Ctf18 RFC-like complex A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. go.json Ctf18-RFC|Ctf18-RLC|RFC (Ctf18) http://purl.obolibrary.org/obo/GO_0031390 GO:0045945 biolink:BiologicalProcess positive regulation of transcription by RNA polymerase III Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III. go.json activation of transcription from RNA polymerase III promoter|positive regulation of transcription from Pol III promoter|positive regulation of transcription from RNA polymerase III promoter|stimulation of transcription from RNA polymerase III promoter|up regulation of transcription from RNA polymerase III promoter|up-regulation of transcription from RNA polymerase III promoter|upregulation of transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0045945 GO:0045946 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045946 GO:0045943 biolink:BiologicalProcess positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. go.json activation of transcription from RNA polymerase I promoter|positive regulation of transcription from Pol I promoter|positive regulation of transcription from RNA polymerase I promoter|stimulation of transcription from RNA polymerase I promoter|up regulation of transcription from RNA polymerase I promoter|up-regulation of transcription from RNA polymerase I promoter|upregulation of transcription from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_0045943 GO:0045944 biolink:BiologicalProcess positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json activation of global transcription from RNA polymerase II promoter|activation of transcription from RNA polymerase II promoter|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of global transcription from Pol II promoter|positive regulation of transcription from Pol II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter, global|stimulation of global transcription from RNA polymerase II promoter|stimulation of transcription from RNA polymerase II promoter|up regulation of global transcription from RNA polymerase II promoter|up regulation of transcription from RNA polymerase II promoter|up-regulation of global transcription from RNA polymerase II promoter|up-regulation of transcription from RNA polymerase II promoter|upregulation of global transcription from RNA polymerase II promoter|upregulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0045944 GO:0031399 biolink:BiologicalProcess regulation of protein modification process Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. go.json http://purl.obolibrary.org/obo/GO_0031399 goslim_yeast GO:0031397 biolink:BiologicalProcess negative regulation of protein ubiquitination Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. go.json down regulation of protein ubiquitination|down-regulation of protein ubiquitination|downregulation of protein ubiquitination|inhibition of protein ubiquitination http://purl.obolibrary.org/obo/GO_0031397 GO:0031398 biolink:BiologicalProcess positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. go.json activation of protein ubiquitination|stimulation of protein ubiquitination|up regulation of protein ubiquitination|up-regulation of protein ubiquitination|upregulation of protein ubiquitination http://purl.obolibrary.org/obo/GO_0031398 GO:0031395 biolink:CellularComponent bursicon neuropeptide hormone complex A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits. go.json http://purl.obolibrary.org/obo/GO_0031395 GO:0031396 biolink:BiologicalProcess regulation of protein ubiquitination Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein. go.json http://purl.obolibrary.org/obo/GO_0031396 GO:0031393 biolink:BiologicalProcess negative regulation of prostaglandin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. go.json down regulation of prostaglandin biosynthetic process|down-regulation of prostaglandin biosynthetic process|downregulation of prostaglandin biosynthetic process|inhibition of prostaglandin biosynthetic process|negative regulation of prostaglandin anabolism|negative regulation of prostaglandin biosynthesis|negative regulation of prostaglandin formation|negative regulation of prostaglandin synthesis http://purl.obolibrary.org/obo/GO_0031393 GO:0031394 biolink:BiologicalProcess positive regulation of prostaglandin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. go.json activation of prostaglandin biosynthetic process|positive regulation of prostaglandin anabolism|positive regulation of prostaglandin biosynthesis|positive regulation of prostaglandin formation|positive regulation of prostaglandin synthesis|stimulation of prostaglandin biosynthetic process|up regulation of prostaglandin biosynthetic process|up-regulation of prostaglandin biosynthetic process|upregulation of prostaglandin biosynthetic process http://purl.obolibrary.org/obo/GO_0031394 GO:0045952 biolink:BiologicalProcess regulation of juvenile hormone catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. go.json regulation of juvenile hormone breakdown|regulation of juvenile hormone catabolism|regulation of juvenile hormone degradation http://purl.obolibrary.org/obo/GO_0045952 GO:0045953 biolink:BiologicalProcess negative regulation of natural killer cell mediated cytotoxicity Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. go.json down regulation of natural killer cell mediated cytotoxicity|down-regulation of natural killer cell mediated cytotoxicity|downregulation of natural killer cell mediated cytotoxicity|inhibition of natural killer cell mediated cytotoxicity|negative regulation of NK cell mediated cell death|negative regulation of NK cell mediated cell killing|negative regulation of NK cell mediated cytolysis|negative regulation of NK cell mediated cytotoxicity|negative regulation of natural killer cell mediated cell death|negative regulation of natural killer cell mediated cell killing|negative regulation of natural killer cell mediated cytolysis http://purl.obolibrary.org/obo/GO_0045953 GO:0045950 biolink:BiologicalProcess negative regulation of mitotic recombination Any process that inhibits or decreases the rate of DNA recombination during mitosis. go.json down regulation of mitotic recombination|down-regulation of mitotic recombination|downregulation of mitotic recombination|inhibition of mitotic recombination|negative regulation of recombination within rDNA repeats http://purl.obolibrary.org/obo/GO_0045950 GO:0045951 biolink:BiologicalProcess positive regulation of mitotic recombination Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis. go.json activation of mitotic recombination|positive regulation of recombination within rDNA repeats|stimulation of mitotic recombination|up regulation of mitotic recombination|up-regulation of mitotic recombination|upregulation of mitotic recombination http://purl.obolibrary.org/obo/GO_0045951 GO:0070909 biolink:MolecularActivity glutamate:gamma-aminobutyric acid antiporter activity Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out). go.json glutamate-gamma-aminobutyric acid antiporter activity|glutamate/gamma-aminobutyric acid antiporter activity|glutamate: GABA antiporter activity http://purl.obolibrary.org/obo/GO_0070909 GO:0070907 biolink:MolecularActivity histidine:histamine antiporter activity Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out). go.json histidine-histamine antiporter activity|histidine/histamine antiporter activity http://purl.obolibrary.org/obo/GO_0070907 GO:0070908 biolink:MolecularActivity tyrosine:tyramine antiporter activity Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out). go.json tyrosine-tyramine antiporter activity|tyrosine/tyramine antiporter activity http://purl.obolibrary.org/obo/GO_0070908 GO:0070916 biolink:CellularComponent inositol phosphoceramide synthase complex A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces). go.json IPC synthase complex http://purl.obolibrary.org/obo/GO_0070916 GO:0031380 biolink:CellularComponent nuclear RNA-directed RNA polymerase complex A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain. go.json RDRC|Rdr1 complex http://purl.obolibrary.org/obo/GO_0031380 GO:0070917 biolink:MolecularActivity inositol phosphoceramide synthase regulator activity Binds to and modulates the activity of inositol phosphoceramide synthase. go.json IPC synthase regulator activity http://purl.obolibrary.org/obo/GO_0070917 GO:0031381 biolink:CellularComponent viral RNA-directed RNA polymerase complex A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus. go.json http://purl.obolibrary.org/obo/GO_0031381 GO:0045958 biolink:BiologicalProcess positive regulation of complement activation, alternative pathway Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway. go.json activation of complement activation, alternative pathway|positive regulation of complement cascade, alternative pathway|stimulation of complement activation, alternative pathway|up regulation of complement activation, alternative pathway|up-regulation of complement activation, alternative pathway|upregulation of complement activation, alternative pathway http://purl.obolibrary.org/obo/GO_0045958 GO:0070914 biolink:BiologicalProcess UV-damage excision repair A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). go.json AER|UV-damaged DNA endonuclease-dependent excision repair|UVDE-dependent excision repair|UVER|alternative excision repair http://purl.obolibrary.org/obo/GO_0070914 GO:0045959 biolink:BiologicalProcess negative regulation of complement activation, classical pathway Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway. go.json down regulation of complement activation, classical pathway|down-regulation of complement activation, classical pathway|downregulation of complement activation, classical pathway|inhibition of complement activation, classical pathway|negative regulation of complement cascade, classical pathway http://purl.obolibrary.org/obo/GO_0045959 GO:0070915 biolink:MolecularActivity lysophosphatidic acid receptor activity Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. go.json LPA receptor activity http://purl.obolibrary.org/obo/GO_0070915 GO:0045956 biolink:BiologicalProcess positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. go.json activation of calcium ion-dependent exocytosis|stimulation of calcium ion-dependent exocytosis|up regulation of calcium ion-dependent exocytosis|up-regulation of calcium ion-dependent exocytosis|upregulation of calcium ion-dependent exocytosis http://purl.obolibrary.org/obo/GO_0045956 GO:0070912 biolink:CellularComponent Ddb1-Ckn1 complex A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases. go.json http://purl.obolibrary.org/obo/GO_0070912 GO:0045957 biolink:BiologicalProcess negative regulation of complement activation, alternative pathway Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway. go.json down regulation of complement activation, alternative pathway|down-regulation of complement activation, alternative pathway|downregulation of complement activation, alternative pathway|inhibition of complement activation, alternative pathway|negative regulation of complement cascade, alternative pathway http://purl.obolibrary.org/obo/GO_0045957 GO:0070913 biolink:CellularComponent Ddb1-Wdr21 complex A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases. go.json http://purl.obolibrary.org/obo/GO_0070913 GO:0045954 biolink:BiologicalProcess positive regulation of natural killer cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. go.json activation of natural killer cell mediated cytotoxicity|positive regulation of NK cell mediated cell death|positive regulation of NK cell mediated cell killing|positive regulation of NK cell mediated cytolysis|positive regulation of NK cell mediated cytotoxicity|positive regulation of natural killer cell mediated cell death|positive regulation of natural killer cell mediated cell killing|positive regulation of natural killer cell mediated cytolysis|stimulation of natural killer cell mediated cytotoxicity|up regulation of natural killer cell mediated cytotoxicity|up-regulation of natural killer cell mediated cytotoxicity|upregulation of natural killer cell mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0045954 GO:0070910 biolink:BiologicalProcess cell wall macromolecule catabolic process involved in cell wall disassembly The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall. go.json http://purl.obolibrary.org/obo/GO_0070910 GO:0070911 biolink:BiologicalProcess global genome nucleotide-excision repair The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. go.json GG-NER|GGR|global genome NER|global genomic nucleotide-excision repair|global genomic repair http://purl.obolibrary.org/obo/GO_0070911 GO:0045955 biolink:BiologicalProcess negative regulation of calcium ion-dependent exocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. go.json down regulation of calcium ion-dependent exocytosis|down-regulation of calcium ion-dependent exocytosis|downregulation of calcium ion-dependent exocytosis|inhibition of calcium ion-dependent exocytosis http://purl.obolibrary.org/obo/GO_0045955 GO:0031388 biolink:BiologicalProcess organic acid phosphorylation The process of introducing one or more phosphate groups into an organic acid. go.json http://purl.obolibrary.org/obo/GO_0031388 GO:0031389 biolink:CellularComponent Rad17 RFC-like complex A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. go.json RFC (Rad17)|Rad17-RFC|Rad17-RLC|Rad24p RFC-like complex http://purl.obolibrary.org/obo/GO_0031389 GO:0031386 biolink:MolecularActivity protein tag activity A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. go.json covalent modifier|protein tag|protein tagging activity|ubiquitin|ubiquitin-like protein modifier http://purl.obolibrary.org/obo/GO_0031386 goslim_drosophila|goslim_generic|goslim_pir|prokaryote_subset GO:0031387 biolink:CellularComponent MPF complex A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC). go.json http://purl.obolibrary.org/obo/GO_0031387 GO:0031384 biolink:BiologicalProcess regulation of initiation of mating projection growth Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi. go.json http://purl.obolibrary.org/obo/GO_0031384 GO:0031385 biolink:BiologicalProcess regulation of termination of mating projection growth Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi. go.json http://purl.obolibrary.org/obo/GO_0031385 GO:0031382 biolink:BiologicalProcess mating projection formation The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi. go.json mating projection assembly|mating projection biogenesis|shmooing http://purl.obolibrary.org/obo/GO_0031382 GO:0031383 biolink:BiologicalProcess regulation of mating projection assembly Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi. go.json regulation of mating projection biogenesis http://purl.obolibrary.org/obo/GO_0031383 GO:0031379 biolink:CellularComponent RNA-directed RNA polymerase complex A protein complex that possesses RNA-directed RNA polymerase activity. go.json http://purl.obolibrary.org/obo/GO_0031379 GO:0045963 biolink:BiologicalProcess negative regulation of dopamine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine. go.json down regulation of dopamine metabolic process|down-regulation of dopamine metabolic process|downregulation of dopamine metabolic process|inhibition of dopamine metabolic process|negative regulation of dopamine metabolism http://purl.obolibrary.org/obo/GO_0045963 GO:0045964 biolink:BiologicalProcess positive regulation of dopamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. go.json activation of dopamine metabolic process|positive regulation of dopamine metabolism|stimulation of dopamine metabolic process|up regulation of dopamine metabolic process|up-regulation of dopamine metabolic process|upregulation of dopamine metabolic process http://purl.obolibrary.org/obo/GO_0045964 GO:0045961 biolink:BiologicalProcess negative regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached. go.json down regulation of development, heterochronic|down-regulation of development, heterochronic|downregulation of development, heterochronic|inhibition of development, heterochronic http://purl.obolibrary.org/obo/GO_0045961 GO:0045962 biolink:BiologicalProcess positive regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached. go.json activation of development, heterochronic|stimulation of development, heterochronic|up regulation of development, heterochronic|up-regulation of development, heterochronic|upregulation of development, heterochronic http://purl.obolibrary.org/obo/GO_0045962 GO:0045960 biolink:BiologicalProcess positive regulation of complement activation, classical pathway Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway. go.json activation of complement activation, classical pathway|positive regulation of complement cascade, classical pathway|stimulation of complement activation, classical pathway|up regulation of complement activation, classical pathway|up-regulation of complement activation, classical pathway|upregulation of complement activation, classical pathway http://purl.obolibrary.org/obo/GO_0045960 GO:0070905 biolink:MolecularActivity serine binding Binding to 2-amino-3-hydroxypropanoic acid. go.json Ser binding http://purl.obolibrary.org/obo/GO_0070905 GO:0070906 biolink:MolecularActivity aspartate:alanine antiporter activity Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out). RHEA:33139 go.json aspartate-alanine antiporter activity|aspartate/alanine antiporter activity http://purl.obolibrary.org/obo/GO_0070906 GO:0031370 biolink:MolecularActivity eukaryotic initiation factor 4G binding Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. go.json eIF4G binding http://purl.obolibrary.org/obo/GO_0031370 GO:0045969 biolink:BiologicalProcess positive regulation of juvenile hormone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. go.json activation of juvenile hormone biosynthetic process|positive regulation of juvenile hormone anabolism|positive regulation of juvenile hormone biosynthesis|positive regulation of juvenile hormone formation|positive regulation of juvenile hormone synthesis|stimulation of juvenile hormone biosynthetic process|up regulation of juvenile hormone biosynthetic process|up-regulation of juvenile hormone biosynthetic process|upregulation of juvenile hormone biosynthetic process http://purl.obolibrary.org/obo/GO_0045969 GO:0070903 biolink:BiologicalProcess mitochondrial tRNA thio-modification The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070903 GO:0070904 biolink:BiologicalProcess obsolete transepithelial L-ascorbic acid transport OBSOLETE. The directed movement of L-ascorbic acid from one side of an epithelium to the other. go.json transepithelial L-ascorbate transport|transepithelial vitamin C transport True http://purl.obolibrary.org/obo/GO_0070904 GO:0070901 biolink:BiologicalProcess mitochondrial tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070901 GO:0045967 biolink:BiologicalProcess negative regulation of growth rate Any process that reduces the rate of growth of all or part of an organism. go.json down regulation of growth rate|down-regulation of growth rate|downregulation of growth rate|inhibition of growth rate http://purl.obolibrary.org/obo/GO_0045967 GO:0045968 biolink:BiologicalProcess negative regulation of juvenile hormone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. go.json down regulation of juvenile hormone biosynthetic process|down-regulation of juvenile hormone biosynthetic process|downregulation of juvenile hormone biosynthetic process|inhibition of juvenile hormone biosynthetic process|negative regulation of juvenile hormone anabolism|negative regulation of juvenile hormone biosynthesis|negative regulation of juvenile hormone formation|negative regulation of juvenile hormone synthesis http://purl.obolibrary.org/obo/GO_0045968 GO:0070902 biolink:BiologicalProcess mitochondrial tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070902 GO:0045965 biolink:BiologicalProcess negative regulation of ecdysteroid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids. go.json down regulation of ecdysteroid metabolic process|down-regulation of ecdysteroid metabolic process|downregulation of ecdysteroid metabolic process|inhibition of ecdysteroid metabolic process|negative regulation of ecdysteroid metabolism http://purl.obolibrary.org/obo/GO_0045965 GO:0045966 biolink:BiologicalProcess positive regulation of ecdysteroid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids. go.json activation of ecdysteroid metabolic process|positive regulation of ecdysteroid metabolism|stimulation of ecdysteroid metabolic process|up regulation of ecdysteroid metabolic process|up-regulation of ecdysteroid metabolic process|upregulation of ecdysteroid metabolic process http://purl.obolibrary.org/obo/GO_0045966 GO:0070900 biolink:BiologicalProcess mitochondrial tRNA modification The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically. go.json http://purl.obolibrary.org/obo/GO_0070900 GO:0031377 biolink:CellularComponent obsolete mitochondrial type II fatty acid synthase complex OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion. go.json mitochondrial type II FAS complex|mitochondrial type II fatty acid synthase complex True http://purl.obolibrary.org/obo/GO_0031377 GO:0031378 biolink:CellularComponent obsolete plastid type II fatty acid synthase complex OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid. go.json plastid type II FAS complex|plastid type II fatty acid synthase complex True http://purl.obolibrary.org/obo/GO_0031378 GO:0031375 biolink:CellularComponent obsolete type II fatty acid synthase complex OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity. go.json type II FAS|type II FAS complex|type II fatty acid synthase|type II fatty acid synthase complex True http://purl.obolibrary.org/obo/GO_0031375 GO:0031376 biolink:CellularComponent obsolete cytosolic type II fatty acid synthase complex OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol. go.json cytosolic type II FAS complex|cytosolic type II fatty acid synthase complex True http://purl.obolibrary.org/obo/GO_0031376 GO:0031373 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031373 GO:0031374 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031374 GO:0031371 biolink:CellularComponent ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity. go.json E2 complex http://purl.obolibrary.org/obo/GO_0031371 goslim_pir GO:0031372 biolink:CellularComponent UBC13-MMS2 complex A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p. go.json http://purl.obolibrary.org/obo/GO_0031372 GO:0031368 biolink:MolecularActivity obsolete Pro-X metallocarboxypeptidase activity OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid. EC:3.4.17.16 go.json Pro-X metallocarboxypeptidase activity|carboxypeptidase P activity|membrane Pro-X carboxypeptidase activity|membrane Pro-Xaa carboxypeptidase|microsomal carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0031368 GO:0031369 biolink:MolecularActivity translation initiation factor binding Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. go.json http://purl.obolibrary.org/obo/GO_0031369 GO:0045974 biolink:BiologicalProcess regulation of translation, ncRNA-mediated Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein. go.json http://purl.obolibrary.org/obo/GO_0045974 GO:0045975 biolink:BiologicalProcess positive regulation of translation, ncRNA-mediated Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein. go.json activation of mRNA translation, ncRNA-mediated|stimulation of mRNA translation, ncRNA-mediated|up regulation of mRNA translation, ncRNA-mediated|up-regulation of mRNA translation, ncRNA-mediated|upregulation of mRNA translation, ncRNA-mediated http://purl.obolibrary.org/obo/GO_0045975 GO:0045972 biolink:BiologicalProcess negative regulation of juvenile hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone. go.json down regulation of juvenile hormone secretion|down-regulation of juvenile hormone secretion|downregulation of juvenile hormone secretion|inhibition of juvenile hormone secretion http://purl.obolibrary.org/obo/GO_0045972 GO:0045973 biolink:BiologicalProcess positive regulation of juvenile hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone. go.json activation of juvenile hormone secretion|stimulation of juvenile hormone secretion|up regulation of juvenile hormone secretion|up-regulation of juvenile hormone secretion|upregulation of juvenile hormone secretion http://purl.obolibrary.org/obo/GO_0045973 GO:0045970 biolink:BiologicalProcess negative regulation of juvenile hormone catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. go.json down regulation of juvenile hormone catabolic process|down-regulation of juvenile hormone catabolic process|downregulation of juvenile hormone catabolic process|inhibition of juvenile hormone catabolic process|negative regulation of juvenile hormone breakdown|negative regulation of juvenile hormone catabolism|negative regulation of juvenile hormone degradation http://purl.obolibrary.org/obo/GO_0045970 GO:0045971 biolink:BiologicalProcess positive regulation of juvenile hormone catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. go.json activation of juvenile hormone catabolic process|positive regulation of juvenile hormone breakdown|positive regulation of juvenile hormone catabolism|positive regulation of juvenile hormone degradation|stimulation of juvenile hormone catabolic process|up regulation of juvenile hormone catabolic process|up-regulation of juvenile hormone catabolic process|upregulation of juvenile hormone catabolic process http://purl.obolibrary.org/obo/GO_0045971 GO:0070929 biolink:BiologicalProcess trans-translation A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes. go.json http://purl.obolibrary.org/obo/GO_0070929 GO:0070938 biolink:CellularComponent contractile ring A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles. go.json constriction ring|cytokinetic ring http://purl.obolibrary.org/obo/GO_0070938 GO:0070939 biolink:CellularComponent Dsl1/NZR complex A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p. go.json CATCHR family complex|Dsl1p complex|NZR complex http://purl.obolibrary.org/obo/GO_0070939 GO:0070936 biolink:BiologicalProcess protein K48-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. go.json protein K48-linked polyubiquitination http://purl.obolibrary.org/obo/GO_0070936 GO:0070937 biolink:CellularComponent CRD-mediated mRNA stability complex A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. go.json coding-region determinant of instability-mediated mRNA stability complex|coding-region instability determinant -mediated mRNA stability complex http://purl.obolibrary.org/obo/GO_0070937 GO:0070934 biolink:BiologicalProcess CRD-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). go.json coding region determinant-mediated mRNA stabilization http://purl.obolibrary.org/obo/GO_0070934 GO:0045978 biolink:BiologicalProcess negative regulation of nucleoside metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. go.json down regulation of nucleoside metabolic process|down-regulation of nucleoside metabolic process|downregulation of nucleoside metabolic process|inhibition of nucleoside metabolic process|negative regulation of nucleoside metabolism http://purl.obolibrary.org/obo/GO_0045978 GO:0045979 biolink:BiologicalProcess positive regulation of nucleoside metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. go.json activation of nucleoside metabolic process|positive regulation of nucleoside metabolism|stimulation of nucleoside metabolic process|up regulation of nucleoside metabolic process|up-regulation of nucleoside metabolic process|upregulation of nucleoside metabolic process http://purl.obolibrary.org/obo/GO_0045979 GO:0070935 biolink:BiologicalProcess 3'-UTR-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. go.json 3'-untranslated region-mediated mRNA stabilization http://purl.obolibrary.org/obo/GO_0070935 GO:0070932 biolink:BiologicalProcess histone H3 deacetylation The modification of histone H3 by the removal of one or more acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0070932 gocheck_do_not_annotate GO:0045976 biolink:BiologicalProcess negative regulation of mitotic cell cycle, embryonic Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle. go.json down regulation of progression through embryonic mitotic cell cycle|down-regulation of progression through embryonic mitotic cell cycle|downregulation of progression through embryonic mitotic cell cycle|inhibition of progression through embryonic mitotic cell cycle|negative regulation of embryonic mitotic cell cycle|negative regulation of embryonic mitotic cell cycle progression|negative regulation of progression through embryonic mitotic cell cycle http://purl.obolibrary.org/obo/GO_0045976 GO:0045977 biolink:BiologicalProcess positive regulation of mitotic cell cycle, embryonic Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle. go.json activation of mitotic cell cycle, embryonic|positive regulation of embryonic mitotic cell cycle|positive regulation of embryonic mitotic cell cycle progression|positive regulation of progression through embryonic mitotic cell cycle|stimulation of mitotic cell cycle, embryonic|up regulation of mitotic cell cycle, embryonic|up-regulation of mitotic cell cycle, embryonic|upregulation of mitotic cell cycle, embryonic http://purl.obolibrary.org/obo/GO_0045977 GO:0070933 biolink:BiologicalProcess histone H4 deacetylation The modification of histone H4 by the removal of one or more acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0070933 gocheck_do_not_annotate GO:0070930 biolink:BiologicalProcess trans-translation-dependent protein tagging A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation. go.json co-translational protein tagging|cotranslational protein tagging|protein modification by trans-translation http://purl.obolibrary.org/obo/GO_0070930 gocheck_do_not_annotate GO:0031366 biolink:BiologicalProcess N-terminal peptidyl-asparagine deamination The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0031366 gocheck_do_not_annotate GO:0070931 biolink:CellularComponent Golgi-associated vesicle lumen The volume enclosed by the membrane of a Golgi-associated vesicle. go.json http://purl.obolibrary.org/obo/GO_0070931 GO:0031367 biolink:BiologicalProcess N-terminal peptidyl-glutamine deamination The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0031367 gocheck_do_not_annotate GO:0031364 biolink:BiologicalProcess N-terminal protein amino acid deamination, from side chain The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0031364 gocheck_do_not_annotate GO:0031365 biolink:BiologicalProcess N-terminal protein amino acid modification The alteration of the N-terminal amino acid residue in a protein. go.json peptide or protein amino-terminal blocking|peptide/protein amino-terminal blocking http://purl.obolibrary.org/obo/GO_0031365 gocheck_do_not_annotate GO:0031362 biolink:CellularComponent obsolete anchored component of external side of plasma membrane OBSOLETE. The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json anchored to external leaflet of plasma membrane|anchored to external side of plasma membrane True http://purl.obolibrary.org/obo/GO_0031362 GO:0031363 biolink:BiologicalProcess N-terminal protein amino acid deamination The removal of an amino group from the N-terminal amino acid residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0031363 gocheck_do_not_annotate GO:0031360 biolink:CellularComponent obsolete intrinsic component of thylakoid membrane OBSOLETE. The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to thylakoid membrane True http://purl.obolibrary.org/obo/GO_0031360 GO:0031361 biolink:CellularComponent obsolete integral component of thylakoid membrane OBSOLETE. The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to thylakoid membrane True http://purl.obolibrary.org/obo/GO_0031361 GO:0031359 biolink:CellularComponent obsolete integral component of chloroplast outer membrane OBSOLETE. The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to chloroplast outer membrane True http://purl.obolibrary.org/obo/GO_0031359 GO:0031357 biolink:CellularComponent obsolete integral component of chloroplast inner membrane OBSOLETE. The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to chloroplast inner membrane True http://purl.obolibrary.org/obo/GO_0031357 GO:0031358 biolink:CellularComponent obsolete intrinsic component of chloroplast outer membrane OBSOLETE. The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to chloroplast outer membrane True http://purl.obolibrary.org/obo/GO_0031358 GO:0045985 biolink:BiologicalProcess positive regulation of pyrimidine nucleobase metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases. go.json activation of pyrimidine base metabolic process|positive regulation of pyrimidine base metabolic process|positive regulation of pyrimidine base metabolism|stimulation of pyrimidine base metabolic process|up regulation of pyrimidine base metabolic process|up-regulation of pyrimidine base metabolic process|upregulation of pyrimidine base metabolic process http://purl.obolibrary.org/obo/GO_0045985 GO:0045986 biolink:BiologicalProcess negative regulation of smooth muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. go.json down regulation of smooth muscle contraction|down-regulation of smooth muscle contraction|downregulation of smooth muscle contraction|inhibition of smooth muscle contraction|smooth muscle relaxation http://purl.obolibrary.org/obo/GO_0045986 GO:0045983 biolink:BiologicalProcess positive regulation of purine nucleobase metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases. go.json activation of purine base metabolic process|positive regulation of purine base metabolic process|positive regulation of purine base metabolism|stimulation of purine base metabolic process|up regulation of purine base metabolic process|up-regulation of purine base metabolic process|upregulation of purine base metabolic process http://purl.obolibrary.org/obo/GO_0045983 GO:0045984 biolink:BiologicalProcess negative regulation of pyrimidine nucleobase metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases. go.json down regulation of pyrimidine base metabolic process|down-regulation of pyrimidine base metabolic process|downregulation of pyrimidine base metabolic process|inhibition of pyrimidine base metabolic process|negative regulation of pyrimidine base metabolic process|negative regulation of pyrimidine base metabolism http://purl.obolibrary.org/obo/GO_0045984 GO:0045981 biolink:BiologicalProcess positive regulation of nucleotide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. go.json activation of nucleotide metabolic process|positive regulation of nucleotide metabolism|stimulation of nucleotide metabolic process|up regulation of nucleotide metabolic process|up-regulation of nucleotide metabolic process|upregulation of nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0045981 GO:0045982 biolink:BiologicalProcess negative regulation of purine nucleobase metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases. go.json down regulation of purine base metabolic process|down-regulation of purine base metabolic process|downregulation of purine base metabolic process|inhibition of purine base metabolic process|negative regulation of purine base metabolic process|negative regulation of purine base metabolism http://purl.obolibrary.org/obo/GO_0045982 GO:0070918 biolink:BiologicalProcess regulatory ncRNA processing A process leading to the generation of a functional regulatory non-coding RNA. go.json gene silencing by RNA, production of guide RNA|gene silencing by RNA, production of small RNA|primary sncRNA processing|production of small RNA involved in gene silencing by RNA|small regulatory ncRNA maturation|small regulatory ncRNA processing|sncRNA processing|sncRNA production http://purl.obolibrary.org/obo/GO_0070918 gocheck_do_not_annotate GO:0045980 biolink:BiologicalProcess negative regulation of nucleotide metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. go.json down regulation of nucleotide metabolic process|down-regulation of nucleotide metabolic process|downregulation of nucleotide metabolic process|inhibition of nucleotide metabolic process|negative regulation of nucleotide metabolism http://purl.obolibrary.org/obo/GO_0045980 GO:0070919 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070919 GO:0070927 biolink:BiologicalProcess negative regulation of ATP:ADP antiporter activity Any process that stops or reduces the activity of an ATP:ADP antiporter. go.json down regulation of ATP:ADP antiporter activity|down-regulation of ATP:ADP antiporter activity|downregulation of ATP:ADP antiporter activity|inhibition of ATP:ADP antiporter activity http://purl.obolibrary.org/obo/GO_0070927 gocheck_do_not_annotate GO:0070928 biolink:BiologicalProcess obsolete regulation of mRNA stability, ncRNA-mediated OBSOLETE. Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. go.json ncRNA-mediated regulation of mRNA stability|regulation of mRNA stability, non-coding RNA-mediated True http://purl.obolibrary.org/obo/GO_0070928 GO:0070925 biolink:BiologicalProcess organelle assembly The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0070925 goslim_yeast GO:0070926 biolink:BiologicalProcess regulation of ATP:ADP antiporter activity Any process that modulates the activity of an ATP:ADP antiporter. go.json http://purl.obolibrary.org/obo/GO_0070926 gocheck_do_not_annotate GO:0070923 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070923 GO:0045989 biolink:BiologicalProcess positive regulation of striated muscle contraction Any process that activates or increases the frequency, rate or extent of striated muscle contraction. go.json activation of striated muscle contraction|stimulation of striated muscle contraction|up regulation of striated muscle contraction|up-regulation of striated muscle contraction|upregulation of striated muscle contraction http://purl.obolibrary.org/obo/GO_0045989 GO:0070924 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070924 GO:0070921 biolink:BiologicalProcess regulation of siRNA processing Any process that modulates the frequency, rate or extent of siRNA processing. go.json regulation of RNA interference, production of siRNA|regulation of chromatin silencing by small RNA, production of siRNA|regulation of production of siRNA involved in PTGS|regulation of production of siRNA involved in RNA interference|regulation of production of siRNA involved in chromatin silencing by small RNA|regulation of production of siRNA involved in gene silencing by small RNA|regulation of production of siRNA involved in post-transcriptional gene silencing by RNA|regulation of siRNA production http://purl.obolibrary.org/obo/GO_0070921 GO:0045987 biolink:BiologicalProcess positive regulation of smooth muscle contraction Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. go.json activation of smooth muscle contraction|stimulation of smooth muscle contraction|up regulation of smooth muscle contraction|up-regulation of smooth muscle contraction|upregulation of smooth muscle contraction http://purl.obolibrary.org/obo/GO_0045987 GO:0070922 biolink:BiologicalProcess RISC complex assembly The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA. go.json RISC assembly|gene silencing by RNA, small RNA loading onto RISC|miRISC assembly|miRNA loading onto RISC|siRNA loading onto RISC involved in RNA interference|siRNA loading onto RISC involved in gene silencing by small RNA|small RNA loading onto RISC http://purl.obolibrary.org/obo/GO_0070922 GO:0045988 biolink:BiologicalProcess negative regulation of striated muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. go.json down regulation of striated muscle contraction|down-regulation of striated muscle contraction|downregulation of striated muscle contraction|inhibition of striated muscle contraction http://purl.obolibrary.org/obo/GO_0045988 GO:0031355 biolink:CellularComponent obsolete integral component of plastid outer membrane OBSOLETE. The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to plastid outer membrane True http://purl.obolibrary.org/obo/GO_0031355 GO:0031356 biolink:CellularComponent obsolete intrinsic component of chloroplast inner membrane OBSOLETE. The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to chloroplast inner membrane True http://purl.obolibrary.org/obo/GO_0031356 GO:0070920 biolink:BiologicalProcess regulation of regulatory ncRNA processing Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing. go.json regulation of gene silencing by RNA, production of guide RNA|regulation of gene silencing by RNA, production of small RNA|regulation of production of small RNA involved in gene silencing by RNA http://purl.obolibrary.org/obo/GO_0070920 GO:0031353 biolink:CellularComponent obsolete integral component of plastid inner membrane OBSOLETE. The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to plastid inner membrane True http://purl.obolibrary.org/obo/GO_0031353 GO:0031354 biolink:CellularComponent obsolete intrinsic component of plastid outer membrane OBSOLETE. The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to plastid outer membrane True http://purl.obolibrary.org/obo/GO_0031354 GO:0031351 biolink:CellularComponent obsolete integral component of plastid membrane OBSOLETE. The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to plastid membrane True http://purl.obolibrary.org/obo/GO_0031351 GO:0031352 biolink:CellularComponent obsolete intrinsic component of plastid inner membrane OBSOLETE. The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to plastid inner membrane True http://purl.obolibrary.org/obo/GO_0031352 GO:0031350 biolink:CellularComponent obsolete intrinsic component of plastid membrane OBSOLETE. The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to plastid membrane True http://purl.obolibrary.org/obo/GO_0031350 GO:0045905 biolink:BiologicalProcess positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. go.json activation of translational termination|stimulation of translational termination|up regulation of translational termination|up-regulation of translational termination|upregulation of translational termination http://purl.obolibrary.org/obo/GO_0045905 GO:0045906 biolink:BiologicalProcess negative regulation of vasoconstriction Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction. go.json down regulation of vasoconstriction|down-regulation of vasoconstriction|downregulation of vasoconstriction|inhibition of vasoconstriction http://purl.obolibrary.org/obo/GO_0045906 GO:0045903 biolink:BiologicalProcess positive regulation of translational fidelity Any process that increases the ability of the translational apparatus to interpret the genetic code. go.json activation of translational fidelity|stimulation of translational fidelity|up regulation of translational fidelity|up-regulation of translational fidelity|upregulation of translational fidelity http://purl.obolibrary.org/obo/GO_0045903 GO:0045904 biolink:BiologicalProcess negative regulation of translational termination Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. go.json down regulation of translational termination|down-regulation of translational termination|downregulation of translational termination|inhibition of translational termination http://purl.obolibrary.org/obo/GO_0045904 GO:0045901 biolink:BiologicalProcess positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. go.json activation of translational elongation|stimulation of translational elongation|up regulation of translational elongation|up-regulation of translational elongation|upregulation of translational elongation http://purl.obolibrary.org/obo/GO_0045901 GO:0045902 biolink:BiologicalProcess negative regulation of translational fidelity Any process that decreases the ability of the translational apparatus to interpret the genetic code. go.json down regulation of translational fidelity|down-regulation of translational fidelity|downregulation of translational fidelity|inhibition of translational fidelity http://purl.obolibrary.org/obo/GO_0045902 GO:0045900 biolink:BiologicalProcess negative regulation of translational elongation Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. go.json down regulation of translational elongation|down-regulation of translational elongation|downregulation of translational elongation|inhibition of translational elongation http://purl.obolibrary.org/obo/GO_0045900 GO:0045909 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045909 GO:0045907 biolink:BiologicalProcess positive regulation of vasoconstriction Any process that activates or increases the frequency, rate or extent of vasoconstriction. go.json activation of vasoconstriction|stimulation of vasoconstriction|up regulation of vasoconstriction|up-regulation of vasoconstriction|upregulation of vasoconstriction http://purl.obolibrary.org/obo/GO_0045907 GO:0045908 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045908 GO:0006308 biolink:BiologicalProcess DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. go.json DNA breakdown|DNA catabolism|DNA degradation http://purl.obolibrary.org/obo/GO_0006308 GO:0006309 biolink:BiologicalProcess apoptotic DNA fragmentation The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. go.json DNA catabolic process during apoptosis|DNA catabolism during apoptosis|DNA fragmentation|DNA fragmentation involved in apoptotic nuclear change|chromatinolysis|endonucleolytic DNA catabolic process involved in apoptosis http://purl.obolibrary.org/obo/GO_0006309 GO:0006306 biolink:BiologicalProcess DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. Wikipedia:DNA_methylation go.json http://purl.obolibrary.org/obo/GO_0006306 GO:0006307 biolink:BiologicalProcess DNA dealkylation involved in DNA repair The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT). go.json http://purl.obolibrary.org/obo/GO_0006307 GO:0006304 biolink:BiologicalProcess DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. go.json http://purl.obolibrary.org/obo/GO_0006304 goslim_pir GO:0006305 biolink:BiologicalProcess DNA alkylation The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. go.json http://purl.obolibrary.org/obo/GO_0006305 GO:0006302 biolink:BiologicalProcess double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. go.json http://purl.obolibrary.org/obo/GO_0006302 GO:0006303 biolink:BiologicalProcess double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. go.json NHEJ http://purl.obolibrary.org/obo/GO_0006303 GO:0021940 biolink:BiologicalProcess positive regulation of cerebellar granule cell precursor proliferation The process that activates or increases the rate or extent of granule cell precursor proliferation. go.json activation of granule cell precursor proliferation|stimulation of granule cell precursor proliferation|up regulation of granule cell precursor proliferation|up-regulation of granule cell precursor proliferation|upregulation of granule cell precursor proliferation http://purl.obolibrary.org/obo/GO_0021940 GO:0006300 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006300 GO:0006301 biolink:BiologicalProcess postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. Wikipedia:Postreplication_repair go.json postreplication DNA repair http://purl.obolibrary.org/obo/GO_0006301 GO:0021949 biolink:BiologicalProcess brainstem precerebellar neuron precursor migration The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem. go.json http://purl.obolibrary.org/obo/GO_0021949 GO:0021941 biolink:BiologicalProcess negative regulation of cerebellar granule cell precursor proliferation The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation. go.json down regulation of granule cell precursor proliferation|down-regulation of granule cell precursor proliferation|downregulation of granule cell precursor proliferation|inhibition of granule cell precursor proliferation http://purl.obolibrary.org/obo/GO_0021941 GO:0021942 biolink:BiologicalProcess radial glia guided migration of Purkinje cell The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer. go.json http://purl.obolibrary.org/obo/GO_0021942 GO:0021943 biolink:BiologicalProcess formation of radial glial scaffolds The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells. go.json Bergmann fiber biosynthesis|Bergmann fiber formation http://purl.obolibrary.org/obo/GO_0021943 GO:0021944 biolink:BiologicalProcess neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration. go.json http://purl.obolibrary.org/obo/GO_0021944 GO:0021945 biolink:BiologicalProcess positive regulation of cerebellar granule cell migration by calcium The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration. go.json calcium-mediated activation of granule cell migration|calcium-mediated positive regulation of granule cell migration|calcium-mediated stimulation of granule cell migration|calcium-mediated up regulation of granule cell migration|calcium-mediated up-regulation of granule cell migration|calcium-mediated upregulation of granule cell migration http://purl.obolibrary.org/obo/GO_0021945 GO:0021946 biolink:BiologicalProcess deep nuclear neuron cell migration The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei. go.json http://purl.obolibrary.org/obo/GO_0021946 GO:0021947 biolink:BiologicalProcess outward migration of deep nuclear neurons The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate. go.json http://purl.obolibrary.org/obo/GO_0021947 GO:0021948 biolink:BiologicalProcess inward migration of deep nuclear neurons The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position. go.json http://purl.obolibrary.org/obo/GO_0021948 GO:0006319 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006319 GO:0006317 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006317 GO:0006318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006318 GO:0006315 biolink:BiologicalProcess homing of group II introns Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure. go.json http://purl.obolibrary.org/obo/GO_0006315 GO:0006316 biolink:BiologicalProcess movement of group I intron Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction. go.json http://purl.obolibrary.org/obo/GO_0006316 GO:0006313 biolink:BiologicalProcess DNA transposition A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. Wikipedia:Transposable_element|Wikipedia:Transposase go.json Class II transposition|transposition, DNA-mediated http://purl.obolibrary.org/obo/GO_0006313 GO:0006314 biolink:BiologicalProcess intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. go.json http://purl.obolibrary.org/obo/GO_0006314 GO:0006311 biolink:BiologicalProcess meiotic gene conversion The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele. go.json gene conversion without reciprocal crossover http://purl.obolibrary.org/obo/GO_0006311 GO:0006312 biolink:BiologicalProcess mitotic recombination The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. Wikipedia:Mitotic_crossover go.json http://purl.obolibrary.org/obo/GO_0006312 GO:0006310 biolink:BiologicalProcess DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. go.json http://purl.obolibrary.org/obo/GO_0006310 goslim_drosophila|goslim_generic|goslim_pombe|goslim_yeast|prokaryote_subset GO:0021938 biolink:BiologicalProcess smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells. go.json hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation|hh signaling pathway involved in regulation of granule cell precursor cell proliferation|smoothened signalling pathway in regulation of granule cell precursor cell proliferation http://purl.obolibrary.org/obo/GO_0021938 GO:0021939 biolink:BiologicalProcess extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation. go.json extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation http://purl.obolibrary.org/obo/GO_0021939 GO:0021930 biolink:BiologicalProcess cerebellar granule cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021930 GO:0021931 biolink:BiologicalProcess rostral hindbrain neuronal precursor cell proliferation The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus. go.json http://purl.obolibrary.org/obo/GO_0021931 GO:0021932 biolink:BiologicalProcess hindbrain radial glia guided cell migration The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain. go.json http://purl.obolibrary.org/obo/GO_0021932 GO:0021933 biolink:BiologicalProcess radial glia guided migration of cerebellar granule cell The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer. go.json http://purl.obolibrary.org/obo/GO_0021933 GO:0021934 biolink:BiologicalProcess hindbrain tangential cell migration The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration. go.json hindbrain neurophilic migration http://purl.obolibrary.org/obo/GO_0021934 GO:0021935 biolink:BiologicalProcess cerebellar granule cell precursor tangential migration The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium. go.json http://purl.obolibrary.org/obo/GO_0021935 GO:0021936 biolink:BiologicalProcess regulation of cerebellar granule cell precursor proliferation The process that modulates the frequency, rate or extent of granule cell precursor proliferation. go.json http://purl.obolibrary.org/obo/GO_0021936 GO:0021937 biolink:BiologicalProcess cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation. go.json Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation http://purl.obolibrary.org/obo/GO_0021937 GO:0021927 biolink:BiologicalProcess deep nuclear neuron precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons. go.json http://purl.obolibrary.org/obo/GO_0021927 GO:0021928 biolink:BiologicalProcess basket cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021928 GO:0021929 biolink:BiologicalProcess stellate cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021929 GO:0021920 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord. go.json True http://purl.obolibrary.org/obo/GO_0021920 GO:0021921 biolink:BiologicalProcess regulation of cell proliferation in dorsal spinal cord The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021921 GO:0021922 biolink:BiologicalProcess Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division. go.json Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord|Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord|Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord http://purl.obolibrary.org/obo/GO_0021922 GO:0021923 biolink:BiologicalProcess cell proliferation in hindbrain ventricular zone The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity. go.json http://purl.obolibrary.org/obo/GO_0021923 GO:0021924 biolink:BiologicalProcess cell proliferation in external granule layer The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere. go.json http://purl.obolibrary.org/obo/GO_0021924 GO:0021925 biolink:BiologicalProcess cerebellar Purkinje cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. go.json http://purl.obolibrary.org/obo/GO_0021925 GO:0021926 biolink:BiologicalProcess Golgi cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. go.json http://purl.obolibrary.org/obo/GO_0021926 GO:0021916 biolink:BiologicalProcess inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis. go.json inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors http://purl.obolibrary.org/obo/GO_0021916 GO:0021917 biolink:BiologicalProcess somatic motor neuron fate commitment The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons. go.json http://purl.obolibrary.org/obo/GO_0021917 GO:0021918 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis. go.json True http://purl.obolibrary.org/obo/GO_0021918 GO:0021919 biolink:BiologicalProcess obsolete BMP signaling pathway involved in spinal cord dorsal/ventral patterning OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord. go.json BMP signaling pathway in spinal cord dorsoventral patterning|BMP signaling pathway involved in spinal cord dorsal-ventral patterning|BMP signalling pathway involved in spinal cord dorsal-ventral patterning|bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning|bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning True http://purl.obolibrary.org/obo/GO_0021919 GO:0021910 biolink:BiologicalProcess smoothened signaling pathway involved in ventral spinal cord patterning The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. go.json hedgehog signaling pathway involved in ventral spinal cord patterning|hh signaling pathway involved in ventral spinal cord patterning|smoothened signalling pathway in ventral spinal cord patterning http://purl.obolibrary.org/obo/GO_0021910 GO:0021911 biolink:BiologicalProcess retinoic acid metabolic process in spinal cord anterior-posterior patterning The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. go.json retinoic acid metabolism in spinal cord anterior-posterior patterning http://purl.obolibrary.org/obo/GO_0021911 GO:0021912 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord. go.json True http://purl.obolibrary.org/obo/GO_0021912 GO:0021913 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord. go.json True http://purl.obolibrary.org/obo/GO_0021913 GO:0021914 biolink:BiologicalProcess negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord. go.json down regulation of smoothened signaling pathway in ventral spinal cord patterning|down-regulation of smoothened signaling pathway in ventral spinal cord patterning|downregulation of smoothened signaling pathway in ventral spinal cord patterning|inhibition of smoothened signaling pathway in ventral spinal cord patterning|negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning|negative regulation of hh signaling pathway involved in ventral spinal cord patterning|negative regulation of smoothened signalling pathway in ventral spinal cord patterning http://purl.obolibrary.org/obo/GO_0021914 GO:0021915 biolink:BiologicalProcess neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. go.json http://purl.obolibrary.org/obo/GO_0021915 GO:0021905 biolink:BiologicalProcess forebrain-midbrain boundary formation The process whose specific outcome is the creation of the forebrain-midbrain boundary. go.json http://purl.obolibrary.org/obo/GO_0021905 GO:0021906 biolink:BiologicalProcess hindbrain-spinal cord boundary formation The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. go.json http://purl.obolibrary.org/obo/GO_0021906 GO:0021907 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. go.json fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning http://purl.obolibrary.org/obo/GO_0021907 GO:0021908 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. go.json retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning http://purl.obolibrary.org/obo/GO_0021908 GO:0021909 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. go.json True http://purl.obolibrary.org/obo/GO_0021909 GO:0021900 biolink:BiologicalProcess ventricular zone cell fate commitment The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons. go.json http://purl.obolibrary.org/obo/GO_0021900 GO:0021901 biolink:BiologicalProcess early neuron fate commitment in forebrain The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021901 GO:0021902 biolink:BiologicalProcess commitment of neuronal cell to specific neuron type in forebrain The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain. go.json http://purl.obolibrary.org/obo/GO_0021902 GO:0021903 biolink:BiologicalProcess rostrocaudal neural tube patterning The process in which the neural tube is divided into specific regions along the rostrocaudal axis. go.json anterior-posterior neural tube patterning http://purl.obolibrary.org/obo/GO_0021903 GO:0021904 biolink:BiologicalProcess dorsal/ventral neural tube patterning The process in which the neural tube is regionalized in the dorsoventral axis. go.json dorsal-ventral neural tube patterning|dorsoventral neural tube patterning http://purl.obolibrary.org/obo/GO_0021904 OBO:GOREL_0000040 biolink:OntologyClass results in GOREL:0000040 go.json http://purl.obolibrary.org/obo/GOREL_0000040 GO:0031469 biolink:CellularComponent bacterial microcompartment An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. go.json BAC|BMC|MCP|polyhedral organelle http://purl.obolibrary.org/obo/GO_0031469 goslim_pir GO:0031467 biolink:CellularComponent Cul7-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein. go.json CDL7 complex|CRL7 complex|SCF7 complex|cullin-RING ligase 7 http://purl.obolibrary.org/obo/GO_0031467 GO:0031468 biolink:BiologicalProcess nuclear membrane reassembly The reformation of the nuclear membranes following their breakdown in the context of a normal process. go.json nuclear envelope reassembly http://purl.obolibrary.org/obo/GO_0031468 GO:0031465 biolink:CellularComponent Cul4B-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits. go.json cullin-RING ligase 4B http://purl.obolibrary.org/obo/GO_0031465 GO:0031466 biolink:CellularComponent Cul5-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. go.json CDL5 complex|CRL5 complex|EC2S complex|SCF5 complex|cullin-RING ligase 5 http://purl.obolibrary.org/obo/GO_0031466 GO:0031463 biolink:CellularComponent Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. go.json BC3B complex|BCR3 complex|CDL3 complex|CRL3 complex|SCF3 complex|cullin-RING ligase 3 http://purl.obolibrary.org/obo/GO_0031463 GO:0031464 biolink:CellularComponent Cul4A-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. go.json CDL4 complex|CRL4 complex|DCX complex|SCF4 complex|VDC complex|cullin-RING ligase 4A http://purl.obolibrary.org/obo/GO_0031464 GO:0031461 biolink:CellularComponent cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. go.json CRL complex|cullin complex|cullin-RING ligase http://purl.obolibrary.org/obo/GO_0031461 GO:0031462 biolink:CellularComponent Cul2-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. go.json CBC complex|CDL2 complex|CRL2 complex|EC2S complex|ECS complex|SCF2 complex|VBC complex|cullin-RING ligase 2 http://purl.obolibrary.org/obo/GO_0031462 GO:0031460 biolink:BiologicalProcess glycine betaine transport The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json N-trimethylglycine transport http://purl.obolibrary.org/obo/GO_0031460 GO:0031458 biolink:MolecularActivity ABC-type betaine transporter activity Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in). go.json ABC-type betaine transmembrane transporter activity|ATP-dependent betaine transporter activity|ATPase-coupled betaine transporter activity|betaine ABC transporter|betaine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0031458 GO:0031459 biolink:MolecularActivity ABC-type glycine betaine transporter activity Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). RHEA:32783 go.json ATP-dependent glycine betaine transporter activity|ATPase-coupled glycine betaine transporter activity|N-trimethylglycine-transporting ATPase activity|glycine betaine ABC transporter|glycine betaine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0031459 GO:0031456 biolink:BiologicalProcess glycine betaine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine. go.json N-trimethylglycine biosynthesis|N-trimethylglycine biosynthetic process|glycine betaine anabolism|glycine betaine biosynthesis|glycine betaine formation|glycine betaine synthesis http://purl.obolibrary.org/obo/GO_0031456 GO:0031457 biolink:BiologicalProcess glycine betaine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine. go.json N-trimethylglycine catabolic process|N-trimethylglycine catabolism|glycine betaine breakdown|glycine betaine catabolism|glycine betaine degradation http://purl.obolibrary.org/obo/GO_0031457 GO:0031454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031454 GO:0031455 biolink:BiologicalProcess glycine betaine metabolic process The chemical reactions and pathways involving glycine betaine, N-trimethylglycine. go.json N-trimethylglycine metabolic process|N-trimethylglycine metabolism|glycine betaine metabolism http://purl.obolibrary.org/obo/GO_0031455 GO:0031452 biolink:BiologicalProcess negative regulation of heterochromatin formation Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation. go.json chromatin decompaction|chromatin decondensation|down regulation of heterochromatin formation|down-regulation of heterochromatin formation|downregulation of heterochromatin formation|inhibition of heterochromatin formation|negative regulation of heterochromatin assembly http://purl.obolibrary.org/obo/GO_0031452 GO:0031453 biolink:BiologicalProcess positive regulation of heterochromatin formation Any process that activates or increases the frequency, rate or extent of heterochromatin formation. go.json activation of heterochromatin formation|positive regulation of heterochromatin assembly|stimulation of heterochromatin formation|up regulation of heterochromatin formation|up-regulation of heterochromatin formation|upregulation of heterochromatin formation http://purl.obolibrary.org/obo/GO_0031453 GO:0031450 biolink:BiologicalProcess negative regulation of slow-twitch skeletal muscle fiber contraction Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction. go.json down regulation of slow-twitch skeletal muscle contraction|down-regulation of slow-twitch skeletal muscle contraction|downregulation of slow-twitch skeletal muscle contraction|inhibition of slow-twitch skeletal muscle contraction|negative regulation of slow-twitch skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0031450 GO:0031451 biolink:BiologicalProcess positive regulation of slow-twitch skeletal muscle fiber contraction Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction. go.json activation of slow-twitch skeletal muscle contraction|positive regulation of slow-twitch skeletal muscle contraction|stimulation of slow-twitch skeletal muscle contraction|up regulation of slow-twitch skeletal muscle contraction|up-regulation of slow-twitch skeletal muscle contraction|upregulation of slow-twitch skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0031451 GO:0031449 biolink:BiologicalProcess regulation of slow-twitch skeletal muscle fiber contraction Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction. go.json regulation of slow-twitch skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0031449 GO:0031447 biolink:BiologicalProcess negative regulation of fast-twitch skeletal muscle fiber contraction Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction. go.json down regulation of fast-twitch skeletal muscle contraction|down-regulation of fast-twitch skeletal muscle contraction|downregulation of fast-twitch skeletal muscle contraction|inhibition of fast-twitch skeletal muscle contraction|negative regulation of fast-twitch skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0031447 GO:0031448 biolink:BiologicalProcess positive regulation of fast-twitch skeletal muscle fiber contraction Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction. go.json activation of fast-twitch skeletal muscle contraction|positive regulation of fast-twitch skeletal muscle contraction|stimulation of fast-twitch skeletal muscle contraction|up regulation of fast-twitch skeletal muscle contraction|up-regulation of fast-twitch skeletal muscle contraction|upregulation of fast-twitch skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0031448 GO:0006489 biolink:BiologicalProcess dolichyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative. go.json dolichyl diphosphate anabolism|dolichyl diphosphate biosynthesis|dolichyl diphosphate formation|dolichyl diphosphate synthesis http://purl.obolibrary.org/obo/GO_0006489 GO:0031445 biolink:BiologicalProcess regulation of heterochromatin formation Any process that modulates the frequency, rate, extent or location of heterochromatin formation. go.json regulation of heterochromatin assembly http://purl.obolibrary.org/obo/GO_0031445 GO:0031446 biolink:BiologicalProcess regulation of fast-twitch skeletal muscle fiber contraction Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction. go.json regulation of fast-twitch skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0031446 GO:0006487 biolink:BiologicalProcess protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. RESID:AA0151|RESID:AA0156|RESID:AA0327 go.json N-glycan biosynthesis|N-glycan metabolism|protein amino acid N-linked glycosylation http://purl.obolibrary.org/obo/GO_0006487 GO:0006488 biolink:BiologicalProcess dolichol-linked oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. go.json N-linked glycan precursor biosynthesis|N-linked glycan precursor biosynthetic process|dolichol-linked oligosaccharide anabolism|dolichol-linked oligosaccharide biosynthesis|dolichol-linked oligosaccharide formation|dolichol-linked oligosaccharide synthesis|oligosaccharide-PP-dolichol assembly http://purl.obolibrary.org/obo/GO_0006488 GO:0006485 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006485 GO:0006486 biolink:BiologicalProcess protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. go.json protein amino acid glycosylation|protein-carbohydrate complex assembly http://purl.obolibrary.org/obo/GO_0006486 goslim_generic|goslim_pombe|goslim_yeast|prokaryote_subset GO:0006483 biolink:BiologicalProcess obsolete peptidyl-aspartic acid/asparagine hydroxylation OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine. go.json aspartic acid/asparagine hydroxylation|peptidyl-aspartic acid/asparagine hydroxylation True http://purl.obolibrary.org/obo/GO_0006483 GO:0006484 biolink:BiologicalProcess obsolete protein cysteine-thiol oxidation OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine. go.json protein cysteine-thiol oxidation True http://purl.obolibrary.org/obo/GO_0006484 GO:0006481 biolink:BiologicalProcess C-terminal protein methylation The methylation of the C-terminal amino acid of a protein. go.json C-terminal protein amino acid methylation http://purl.obolibrary.org/obo/GO_0006481 gocheck_do_not_annotate GO:0006482 biolink:BiologicalProcess protein demethylation The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. go.json protein amino acid demethylation http://purl.obolibrary.org/obo/GO_0006482 gocheck_do_not_annotate GO:0006490 biolink:BiologicalProcess oligosaccharide-lipid intermediate biosynthetic process The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. go.json oligosaccharide-lipid intermediate assembly http://purl.obolibrary.org/obo/GO_0006490 GO:0006491 biolink:BiologicalProcess N-glycan processing The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. go.json N-linked glycoprotein maturation|glycoprotein trimming involved in glycoprotein maturation http://purl.obolibrary.org/obo/GO_0006491 GO:0031443 biolink:BiologicalProcess fast-twitch skeletal muscle fiber contraction A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability. go.json fast-twitch skeletal fiber contraction|fast-twitch skeletal fibre contraction|fast-twitch skeletal muscle fibre contraction|fast-twitch skeletal myofiber contraction|fast-twitch skeletal myofibre contraction http://purl.obolibrary.org/obo/GO_0031443 GO:0031444 biolink:BiologicalProcess slow-twitch skeletal muscle fiber contraction A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue. go.json slow-twitch skeletal muscle fibre contraction http://purl.obolibrary.org/obo/GO_0031444 GO:0031441 biolink:BiologicalProcess negative regulation of mRNA 3'-end processing Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing. go.json down regulation of mRNA 3'-end processing|down-regulation of mRNA 3'-end processing|downregulation of mRNA 3'-end processing|inhibition of mRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0031441 GO:0031442 biolink:BiologicalProcess positive regulation of mRNA 3'-end processing Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. go.json activation of mRNA 3'-end processing|stimulation of mRNA 3'-end processing|up regulation of mRNA 3'-end processing|up-regulation of mRNA 3'-end processing|upregulation of mRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0031442 GO:0031440 biolink:BiologicalProcess regulation of mRNA 3'-end processing Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0031440 GO:0031438 biolink:BiologicalProcess obsolete negative regulation of mRNA cleavage OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage. go.json down regulation of mRNA cleavage|down-regulation of mRNA cleavage|downregulation of mRNA cleavage|inhibition of mRNA cleavage True http://purl.obolibrary.org/obo/GO_0031438 GO:0031439 biolink:BiologicalProcess obsolete positive regulation of mRNA cleavage OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA cleavage. go.json activation of mRNA cleavage|stimulation of mRNA cleavage|up regulation of mRNA cleavage|up-regulation of mRNA cleavage|upregulation of mRNA cleavage True http://purl.obolibrary.org/obo/GO_0031439 GO:0031436 biolink:CellularComponent BRCA1-BARD1 complex A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage. go.json http://purl.obolibrary.org/obo/GO_0031436 GO:0031437 biolink:BiologicalProcess obsolete regulation of mRNA cleavage OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. go.json True http://purl.obolibrary.org/obo/GO_0031437 GO:0031434 biolink:MolecularActivity mitogen-activated protein kinase kinase binding Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase. go.json MAPKK binding http://purl.obolibrary.org/obo/GO_0031434 GO:0031435 biolink:MolecularActivity mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. go.json MAPKKK binding http://purl.obolibrary.org/obo/GO_0031435 GO:0006498 biolink:BiologicalProcess N-terminal protein lipidation The covalent attachment of a lipid group to the amino terminus of a protein. go.json http://purl.obolibrary.org/obo/GO_0006498 gocheck_do_not_annotate GO:0006499 biolink:BiologicalProcess N-terminal protein myristoylation The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0006499 gocheck_do_not_annotate GO:0006496 biolink:BiologicalProcess obsolete protein amino acid terminal N-glycosylation OBSOLETE. The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide. go.json protein amino acid terminal N-glycosylation True http://purl.obolibrary.org/obo/GO_0006496 GO:0006497 biolink:BiologicalProcess protein lipidation The covalent attachment of lipid groups to an amino acid in a protein. RESID:AA0059|RESID:AA0060|RESID:AA0077|RESID:AA0078|RESID:AA0079|RESID:AA0080|RESID:AA0102|RESID:AA0103|RESID:AA0104|RESID:AA0106|RESID:AA0107|RESID:AA0158|RESID:AA0159|RESID:AA0160|RESID:AA0161|RESID:AA0162|RESID:AA0163|RESID:AA0166|RESID:AA0223|RESID:AA0290|RESID:AA0307|RESID:AA0308|RESID:AA0309|RESID:AA0316 go.json lipid:protein modification|protein amino acid lipidation http://purl.obolibrary.org/obo/GO_0006497 gocheck_do_not_annotate|goslim_drosophila|goslim_yeast GO:0006494 biolink:BiologicalProcess obsolete protein amino acid terminal glycosylation OBSOLETE. A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide. go.json protein amino acid terminal glycosylation True http://purl.obolibrary.org/obo/GO_0006494 GO:0006495 biolink:BiologicalProcess obsolete terminal O-glycosylation OBSOLETE. (Was not defined before being made obsolete). go.json terminal O-glycosylation True http://purl.obolibrary.org/obo/GO_0006495 GO:0006492 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006492 GO:0006493 biolink:BiologicalProcess protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. RESID:AA0153|RESID:AA0154|RESID:AA0155|RESID:AA0157|RESID:AA0212 go.json protein amino acid O-linked glycosylation http://purl.obolibrary.org/obo/GO_0006493 GO:0031432 biolink:MolecularActivity titin binding Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. go.json http://purl.obolibrary.org/obo/GO_0031432 GO:0031433 biolink:MolecularActivity telethonin binding Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. go.json http://purl.obolibrary.org/obo/GO_0031433 GO:0031430 biolink:CellularComponent M band The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. Wikipedia:Sarcomere#bands go.json M disc|M line|mesophragma|midline http://purl.obolibrary.org/obo/GO_0031430 GO:0031431 biolink:CellularComponent Dbf4-dependent protein kinase complex A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins. go.json Cdc7-Dbf4 complex|DDK|Hsk1-Dfp1 kinase complex http://purl.obolibrary.org/obo/GO_0031431 GO:0031429 biolink:CellularComponent box H/ACA snoRNP complex A box H/ACA RNP complex that is located in the nucleolus. go.json box H/ACA small nucleolar ribonucleoprotein complex|box H/ACA snoRNP pseudouridylase complex http://purl.obolibrary.org/obo/GO_0031429 GO:0031427 biolink:BiologicalProcess response to methotrexate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase. go.json http://purl.obolibrary.org/obo/GO_0031427 GO:0031428 biolink:CellularComponent box C/D RNP complex A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya. go.json box C/D sRNP complex|box C/D small nucleolar ribonucleoprotein complex|box C/D snoRNP complex|box C/D snoRNP ribose 2'-O methylase complex|box C/D snoRNP ribose-2'-O-methyltransferase complex http://purl.obolibrary.org/obo/GO_0031428 GO:0031425 biolink:BiologicalProcess chloroplast RNA processing The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules. go.json http://purl.obolibrary.org/obo/GO_0031425 GO:0006469 biolink:BiologicalProcess negative regulation of protein kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. go.json down regulation of protein kinase activity|down-regulation of protein kinase activity|downregulation of protein kinase activity|inhibition of protein kinase activity http://purl.obolibrary.org/obo/GO_0006469 gocheck_do_not_annotate GO:0031426 biolink:BiologicalProcess polycistronic mRNA processing The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules. go.json http://purl.obolibrary.org/obo/GO_0031426 GO:0006467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006467 GO:0031423 biolink:MolecularActivity hexon binding Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus. go.json http://purl.obolibrary.org/obo/GO_0031423 GO:0006468 biolink:BiologicalProcess protein phosphorylation The process of introducing a phosphate group on to a protein. go.json protein amino acid phosphorylation http://purl.obolibrary.org/obo/GO_0006468 gocheck_do_not_annotate|goslim_yeast GO:0031424 biolink:BiologicalProcess keratinization The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. go.json http://purl.obolibrary.org/obo/GO_0031424 GO:0006465 biolink:BiologicalProcess signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. go.json leader peptide processing http://purl.obolibrary.org/obo/GO_0006465 GO:0006466 biolink:BiologicalProcess obsolete protein disulfide-isomerase reaction OBSOLETE. (Was not defined before being made obsolete). go.json protein disulfide-isomerase reaction|protein disulphide-isomerase reaction True http://purl.obolibrary.org/obo/GO_0006466 GO:0006463 biolink:BiologicalProcess steroid hormone receptor complex assembly The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. go.json http://purl.obolibrary.org/obo/GO_0006463 GO:0006464 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006464 GO:0006461 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006461 GO:0006462 biolink:BiologicalProcess obsolete protein complex assembly, multichaperone pathway OBSOLETE. (Was not defined before being made obsolete). go.json protein complex assembly, multichaperone pathway True http://purl.obolibrary.org/obo/GO_0006462 GO:0006460 biolink:BiologicalProcess obsolete peptidyl-prolyl isomerase B reaction OBSOLETE. (Was not defined before being made obsolete). go.json peptidyl-prolyl isomerase B reaction True http://purl.obolibrary.org/obo/GO_0006460 GO:0031421 biolink:CellularComponent invertasome A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts. go.json http://purl.obolibrary.org/obo/GO_0031421 GO:0031422 biolink:CellularComponent RecQ family helicase-topoisomerase III complex A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human. go.json RecQ helicase-Topo III complex|Sgs1-Top3 complex http://purl.obolibrary.org/obo/GO_0031422 GO:0031420 biolink:MolecularActivity alkali metal ion binding Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. go.json http://purl.obolibrary.org/obo/GO_0031420 GO:0031418 biolink:MolecularActivity L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. go.json L-ascorbate binding|vitamin C binding http://purl.obolibrary.org/obo/GO_0031418 GO:0031419 biolink:MolecularActivity cobalamin binding Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. go.json vitamin B12 binding http://purl.obolibrary.org/obo/GO_0031419 GO:0031416 biolink:CellularComponent NatB complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. go.json N-terminal acetyltransferase B complex http://purl.obolibrary.org/obo/GO_0031416 GO:0031417 biolink:CellularComponent NatC complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p. go.json N-terminal acetyltransferase C complex http://purl.obolibrary.org/obo/GO_0031417 GO:0031414 biolink:CellularComponent N-terminal protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. go.json NAT complex http://purl.obolibrary.org/obo/GO_0031414 GO:0031415 biolink:CellularComponent NatA complex A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. go.json N-terminal acetyltransferase A complex http://purl.obolibrary.org/obo/GO_0031415 GO:0031412 biolink:BiologicalProcess gas vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. go.json gas vesicle biosynthesis|gas vesicle formation|gas vesicle organisation|gas vesicle organization and biogenesis http://purl.obolibrary.org/obo/GO_0031412 GO:0006478 biolink:BiologicalProcess peptidyl-tyrosine sulfation The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine. RESID:AA0172 go.json peptidyl-tyrosine sulphation http://purl.obolibrary.org/obo/GO_0006478 gocheck_do_not_annotate GO:0031413 biolink:BiologicalProcess regulation of buoyancy Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases. go.json buoyancy regulation http://purl.obolibrary.org/obo/GO_0031413 GO:0006479 biolink:BiologicalProcess protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. go.json protein amino acid methylation http://purl.obolibrary.org/obo/GO_0006479 gocheck_do_not_annotate GO:0006476 biolink:BiologicalProcess protein deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json protein amino acid deacetylation http://purl.obolibrary.org/obo/GO_0006476 gocheck_do_not_annotate GO:0006477 biolink:BiologicalProcess protein sulfation The addition of a sulfate group as an ester to a protein amino acid. go.json protein amino acid sulfation|protein amino acid sulphation http://purl.obolibrary.org/obo/GO_0006477 gocheck_do_not_annotate GO:0006474 biolink:BiologicalProcess N-terminal protein amino acid acetylation The acetylation of the N-terminal amino acid of proteins. go.json N(alpha)-terminal acetylation http://purl.obolibrary.org/obo/GO_0006474 gocheck_do_not_annotate GO:0006475 biolink:BiologicalProcess internal protein amino acid acetylation The addition of an acetyl group to a non-terminal amino acid in a protein. go.json http://purl.obolibrary.org/obo/GO_0006475 gocheck_do_not_annotate GO:0006472 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006472 GO:0006473 biolink:BiologicalProcess protein acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json protein amino acid acetylation http://purl.obolibrary.org/obo/GO_0006473 gocheck_do_not_annotate GO:0006470 biolink:BiologicalProcess protein dephosphorylation The process of removing one or more phosphoric residues from a protein. go.json protein amino acid dephosphorylation http://purl.obolibrary.org/obo/GO_0006470 gocheck_do_not_annotate|goslim_yeast GO:0006471 biolink:BiologicalProcess obsolete protein ADP-ribosylation OBSOLETE. The transfer, from NAD, of ADP-ribose to protein amino acids. RESID:AA0040|RESID:AA0168|RESID:AA0169|RESID:AA0231|RESID:AA0237|RESID:AA0295 go.json protein amino acid ADP-ribosylation True http://purl.obolibrary.org/obo/GO_0006471 GO:0006480 biolink:BiologicalProcess N-terminal protein amino acid methylation The methylation of the N-terminal amino acid of a protein. go.json http://purl.obolibrary.org/obo/GO_0006480 gocheck_do_not_annotate GO:0031410 biolink:CellularComponent cytoplasmic vesicle A vesicle found in the cytoplasm of a cell. NIF_Subcellular:sao180601769 go.json cytoplasmic membrane bounded vesicle|cytoplasmic membrane-enclosed vesicle|cytoplasmic, membrane-bounded vesicle http://purl.obolibrary.org/obo/GO_0031410 goslim_agr|goslim_candida|goslim_chembl|goslim_generic|goslim_mouse|goslim_yeast GO:0031411 biolink:CellularComponent gas vesicle An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations. go.json gas vacuole http://purl.obolibrary.org/obo/GO_0031411 GO:0031407 biolink:BiologicalProcess oxylipin metabolic process The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. go.json oxylipin metabolism http://purl.obolibrary.org/obo/GO_0031407 GO:0031408 biolink:BiologicalProcess oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. go.json oxylipin anabolism|oxylipin biosynthesis|oxylipin formation|oxylipin synthesis http://purl.obolibrary.org/obo/GO_0031408 GO:0006449 biolink:BiologicalProcess regulation of translational termination Any process that modulates the frequency, rate or extent of translational termination. go.json http://purl.obolibrary.org/obo/GO_0006449 GO:0031405 biolink:MolecularActivity lipoic acid binding Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid. go.json http://purl.obolibrary.org/obo/GO_0031405 GO:0031406 biolink:MolecularActivity carboxylic acid binding Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-). go.json http://purl.obolibrary.org/obo/GO_0031406 goslim_pir GO:0031403 biolink:MolecularActivity lithium ion binding Binding to a lithium ion (Li+). go.json Li+ ion binding http://purl.obolibrary.org/obo/GO_0031403 GO:0006447 biolink:BiologicalProcess regulation of translational initiation by iron Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron. go.json http://purl.obolibrary.org/obo/GO_0006447 GO:0031404 biolink:MolecularActivity chloride ion binding Binding to a chloride ion (Cl-). go.json Cl- ion binding|chloride binding http://purl.obolibrary.org/obo/GO_0031404 GO:0006448 biolink:BiologicalProcess regulation of translational elongation Any process that modulates the frequency, rate, extent or accuracy of translational elongation. go.json http://purl.obolibrary.org/obo/GO_0006448 GO:0006445 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006445 GO:0031401 biolink:BiologicalProcess positive regulation of protein modification process Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. go.json activation of protein modification|stimulation of protein modification|up regulation of protein modification|up-regulation of protein modification|upregulation of protein modification http://purl.obolibrary.org/obo/GO_0031401 GO:0031402 biolink:MolecularActivity sodium ion binding Binding to a sodium ion (Na+). go.json Na+ ion binding http://purl.obolibrary.org/obo/GO_0031402 GO:0006446 biolink:BiologicalProcess regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. go.json http://purl.obolibrary.org/obo/GO_0006446 GO:0006443 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006443 GO:0006444 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006444 GO:0006441 biolink:BiologicalProcess obsolete binding to mRNA cap OBSOLETE. (Was not defined before being made obsolete). go.json binding to mRNA cap True http://purl.obolibrary.org/obo/GO_0006441 GO:0006442 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006442 GO:0006440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006440 GO:0031409 biolink:MolecularActivity pigment binding Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin. go.json http://purl.obolibrary.org/obo/GO_0031409 goslim_pir GO:0031400 biolink:BiologicalProcess negative regulation of protein modification process Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. go.json down regulation of protein modification|down-regulation of protein modification|downregulation of protein modification|inhibition of protein modification http://purl.obolibrary.org/obo/GO_0031400 GO:0006458 biolink:BiologicalProcess 'de novo' protein folding The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. go.json nascent chain protein folding http://purl.obolibrary.org/obo/GO_0006458 GO:0006459 biolink:BiologicalProcess obsolete binding unfolded ER proteins OBSOLETE. (Was not defined before being made obsolete). go.json binding unfolded ER proteins True http://purl.obolibrary.org/obo/GO_0006459 GO:0006456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006456 GO:0006457 biolink:BiologicalProcess protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. Wikipedia:Protein_folding go.json alpha-tubulin folding|beta-tubulin folding|chaperone activity|chaperonin ATPase activity|chaperonin-mediated tubulin folding|co-chaperone activity|co-chaperonin activity|glycoprotein-specific chaperone activity|non-chaperonin molecular chaperone ATPase activity|protein complex assembly, multichaperone pathway http://purl.obolibrary.org/obo/GO_0006457 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_pombe|goslim_yeast|prokaryote_subset GO:0006454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006454 GO:0006455 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006455 GO:0006452 biolink:BiologicalProcess translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. Wikipedia:Translational_frameshift go.json http://purl.obolibrary.org/obo/GO_0006452 GO:0006453 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006453 GO:0006450 biolink:BiologicalProcess regulation of translational fidelity Any process that modulates the ability of the translational apparatus to interpret the genetic code. go.json regulation of translational accuracy http://purl.obolibrary.org/obo/GO_0006450 GO:0006451 biolink:BiologicalProcess translational readthrough The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. go.json natural nonsense suppression http://purl.obolibrary.org/obo/GO_0006451 GO:0031490 biolink:MolecularActivity chromatin DNA binding Binding to DNA that is assembled into chromatin. go.json http://purl.obolibrary.org/obo/GO_0031490 GO:0031491 biolink:MolecularActivity nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. go.json http://purl.obolibrary.org/obo/GO_0031491 GO:0031498 biolink:BiologicalProcess obsolete chromatin disassembly OBSOLETE. The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. go.json chromatin maintenance True http://purl.obolibrary.org/obo/GO_0031498 GO:0031499 biolink:CellularComponent TRAMP complex A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. Wikipedia:TRAMP_complex go.json TRAMP4 complex|TRAMP5 complex|Trf4 complex|Trf4 poly(A) polymerase complex|Trf4p-Air2p-Mtr4p polyadenylation complex http://purl.obolibrary.org/obo/GO_0031499 GO:0031496 biolink:BiologicalProcess positive regulation of mating type switching Any process that activates or increases the frequency, rate or extent of mating type switching. go.json activation of mating type switching|stimulation of mating type switching|up regulation of mating type switching|up-regulation of mating type switching|upregulation of mating type switching http://purl.obolibrary.org/obo/GO_0031496 GO:0031497 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031497 GO:0031494 biolink:BiologicalProcess regulation of mating type switching Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. go.json http://purl.obolibrary.org/obo/GO_0031494 GO:0031495 biolink:BiologicalProcess negative regulation of mating type switching Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching. go.json down regulation of mating type switching|down-regulation of mating type switching|downregulation of mating type switching|inhibition of mating type switching http://purl.obolibrary.org/obo/GO_0031495 GO:0031492 biolink:MolecularActivity nucleosomal DNA binding Binding to the DNA portion of a nucleosome. go.json http://purl.obolibrary.org/obo/GO_0031492 GO:0031493 biolink:MolecularActivity obsolete nucleosomal histone binding OBSOLETE. Binding to a histone that is assembled into a nucleosome. go.json True http://purl.obolibrary.org/obo/GO_0031493 GO:0031489 biolink:MolecularActivity myosin V binding Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. go.json http://purl.obolibrary.org/obo/GO_0031489 GO:0031480 biolink:CellularComponent myosin X complex A myosin complex containing one or more class X myosin heavy chains and associated light chains. go.json http://purl.obolibrary.org/obo/GO_0031480 GO:0031487 biolink:CellularComponent myosin XVII complex A myosin complex containing one or more class XVII myosin heavy chains and associated light chains. go.json http://purl.obolibrary.org/obo/GO_0031487 GO:0031488 biolink:CellularComponent myosin XVIII complex A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain. go.json http://purl.obolibrary.org/obo/GO_0031488 GO:0031485 biolink:CellularComponent myosin XV complex A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII. go.json http://purl.obolibrary.org/obo/GO_0031485 GO:0031486 biolink:CellularComponent myosin XVI complex A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat. go.json http://purl.obolibrary.org/obo/GO_0031486 GO:0031483 biolink:CellularComponent myosin XIII complex A myosin complex containing one or more class XIII myosin heavy chains and associated light chains. go.json http://purl.obolibrary.org/obo/GO_0031483 GO:0031484 biolink:CellularComponent myosin XIV complex A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails. go.json http://purl.obolibrary.org/obo/GO_0031484 GO:0031481 biolink:CellularComponent myosin XI complex A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions. go.json http://purl.obolibrary.org/obo/GO_0031481 GO:0031482 biolink:CellularComponent myosin XII complex A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil. go.json http://purl.obolibrary.org/obo/GO_0031482 GO:0031478 biolink:CellularComponent myosin VIII complex A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain. go.json http://purl.obolibrary.org/obo/GO_0031478 GO:0031479 biolink:CellularComponent myosin IX complex A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins. go.json http://purl.obolibrary.org/obo/GO_0031479 GO:0031476 biolink:CellularComponent myosin VI complex A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. go.json http://purl.obolibrary.org/obo/GO_0031476 GO:0031477 biolink:CellularComponent myosin VII complex A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain. go.json http://purl.obolibrary.org/obo/GO_0031477 GO:0031474 biolink:CellularComponent myosin IV complex A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV. go.json http://purl.obolibrary.org/obo/GO_0031474 GO:0031475 biolink:CellularComponent myosin V complex A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region. go.json http://purl.obolibrary.org/obo/GO_0031475 GO:0031472 biolink:CellularComponent propanediol degradation polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase. go.json http://purl.obolibrary.org/obo/GO_0031472 GO:0031473 biolink:MolecularActivity myosin III binding Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain. go.json http://purl.obolibrary.org/obo/GO_0031473 GO:0031470 biolink:CellularComponent carboxysome An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO2. It augments the concentration of CO2 in the vicinity of RuBisCO to increase the efficiency of CO2 fixation under atmospheric conditions. Wikipedia:Carboxysome go.json http://purl.obolibrary.org/obo/GO_0031470 GO:0031471 biolink:CellularComponent ethanolamine degradation polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. go.json ethanolamine metabolosome http://purl.obolibrary.org/obo/GO_0031471 GO:0006429 biolink:BiologicalProcess leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006429 GO:0006427 biolink:BiologicalProcess histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006427 GO:0006428 biolink:BiologicalProcess isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006428 GO:0006425 biolink:BiologicalProcess glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006425 GO:0006426 biolink:BiologicalProcess glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. go.json http://purl.obolibrary.org/obo/GO_0006426 GO:0006423 biolink:BiologicalProcess cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006423 GO:0006424 biolink:BiologicalProcess glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006424 GO:0006421 biolink:BiologicalProcess asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006421 GO:0006422 biolink:BiologicalProcess aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006422 GO:0006420 biolink:BiologicalProcess arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006420 GO:0006438 biolink:BiologicalProcess valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006438 GO:0006439 biolink:BiologicalProcess obsolete aminoacyl-tRNA hydrolase reaction OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA. go.json aminoacyl-tRNA hydrolase reaction True http://purl.obolibrary.org/obo/GO_0006439 GO:0006436 biolink:BiologicalProcess tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006436 GO:0006437 biolink:BiologicalProcess tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006437 GO:0006434 biolink:BiologicalProcess seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006434 GO:0006435 biolink:BiologicalProcess threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006435 GO:0006432 biolink:BiologicalProcess phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006432 GO:0006433 biolink:BiologicalProcess prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006433 GO:0006430 biolink:BiologicalProcess lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006430 GO:0006431 biolink:BiologicalProcess methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. go.json http://purl.obolibrary.org/obo/GO_0006431 GO:0006407 biolink:BiologicalProcess rRNA export from nucleus The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins. go.json rRNA export from cell nucleus|rRNA export out of nucleus|rRNA transport from nucleus to cytoplasm|rRNA-nucleus export http://purl.obolibrary.org/obo/GO_0006407 GO:0006408 biolink:BiologicalProcess snRNA export from nucleus The directed movement of snRNA from the nucleus to the cytoplasm. go.json snRNA export from cell nucleus|snRNA export out of nucleus|snRNA transport from nucleus to cytoplasm|snRNA-nucleus export http://purl.obolibrary.org/obo/GO_0006408 GO:0006405 biolink:BiologicalProcess RNA export from nucleus The directed movement of RNA from the nucleus to the cytoplasm. go.json RNA export from cell nucleus|RNA export out of nucleus|RNA transport from nucleus to cytoplasm|RNA-nucleus export http://purl.obolibrary.org/obo/GO_0006405 GO:0006406 biolink:BiologicalProcess mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm. go.json mRNA export from cell nucleus|mRNA export out of nucleus|mRNA transport from nucleus to cytoplasm|mRNA-nucleus export http://purl.obolibrary.org/obo/GO_0006406 GO:0006403 biolink:BiologicalProcess RNA localization A process in which RNA is transported to, or maintained in, a specific location. go.json RNA localisation|establishment and maintenance of RNA localization http://purl.obolibrary.org/obo/GO_0006403 goslim_drosophila GO:0006404 biolink:BiologicalProcess RNA import into nucleus The import of RNA from the cytoplasm to the nucleus. go.json RNA import into cell nucleus|RNA transport from cytoplasm to nucleus|RNA-nucleus import http://purl.obolibrary.org/obo/GO_0006404 GO:0006401 biolink:BiologicalProcess RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. go.json RNA breakdown|RNA catabolism|RNA degradation http://purl.obolibrary.org/obo/GO_0006401 goslim_yeast GO:0006402 biolink:BiologicalProcess mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. go.json mRNA breakdown|mRNA catabolism|mRNA decay|mRNA degradation http://purl.obolibrary.org/obo/GO_0006402 GO:0006400 biolink:BiologicalProcess tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. go.json tRNA editing http://purl.obolibrary.org/obo/GO_0006400 GO:0006409 biolink:BiologicalProcess tRNA export from nucleus The directed movement of tRNA from the nucleus to the cytoplasm. go.json tRNA export from cell nucleus|tRNA export out of nucleus|tRNA transport from nucleus to cytoplasm|tRNA-nucleus export http://purl.obolibrary.org/obo/GO_0006409 GO:0006418 biolink:BiologicalProcess tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. MetaCyc:TRNA-CHARGING-PWY go.json tRNA charging http://purl.obolibrary.org/obo/GO_0006418 goslim_yeast GO:0006419 biolink:BiologicalProcess alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. go.json http://purl.obolibrary.org/obo/GO_0006419 GO:0006416 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006416 GO:0006417 biolink:BiologicalProcess regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. go.json regulation of protein anabolism|regulation of protein biosynthesis|regulation of protein formation|regulation of protein synthesis http://purl.obolibrary.org/obo/GO_0006417 goslim_yeast GO:0006414 biolink:BiologicalProcess translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. go.json protein synthesis elongation|translation elongation http://purl.obolibrary.org/obo/GO_0006414 goslim_yeast GO:0006415 biolink:BiologicalProcess translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). go.json protein synthesis termination|translation termination|translational complex disassembly http://purl.obolibrary.org/obo/GO_0006415 GO:0006412 biolink:BiologicalProcess translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. Wikipedia:Translation_(genetics) go.json protein anabolism|protein biosynthesis|protein biosynthetic process|protein formation|protein synthesis|protein translation http://purl.obolibrary.org/obo/GO_0006412 goslim_candida|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_pir|goslim_plant|prokaryote_subset GO:0006413 biolink:BiologicalProcess translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. go.json biopolymerisation|biopolymerization|protein synthesis initiation|translation initiation http://purl.obolibrary.org/obo/GO_0006413 goslim_yeast GO:0006410 biolink:BiologicalProcess obsolete transcription, RNA-dependent OBSOLETE. The cellular synthesis of DNA on a template of RNA. go.json transcription, RNA-dependent True http://purl.obolibrary.org/obo/GO_0006410 GO:0006411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006411 GO:0031588 biolink:CellularComponent nucleotide-activated protein kinase complex A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). go.json 5'-AMP-activated protein kinase complex|ADP-activated protein kinase complex|AMP-activated protein kinase complex|AMPK complex|SNF1/AMPK protein kinase complex|Snf1 kinase complex|Snf1 serine/threonine protein kinase complex http://purl.obolibrary.org/obo/GO_0031588 GO:0031589 biolink:BiologicalProcess cell-substrate adhesion The attachment of a cell to the underlying substrate via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0031589 GO:0031586 biolink:BiologicalProcess negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. go.json down regulation of IP3 receptor activity|down-regulation of IP3 receptor activity|downregulation of IP3 receptor activity|inhibition of IP3 receptor activity|negative regulation of IP3 receptor activity|negative regulation of inositol 1,4,5-trisphosphate receptor activity http://purl.obolibrary.org/obo/GO_0031586 gocheck_do_not_annotate GO:0031587 biolink:BiologicalProcess positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. go.json activation of IP3 receptor activity|positive regulation of IP3 receptor activity|positive regulation of inositol-1,4,5-trisphosphate receptor activity|stimulation of IP3 receptor activity|up regulation of IP3 receptor activity|up-regulation of IP3 receptor activity|upregulation of IP3 receptor activity http://purl.obolibrary.org/obo/GO_0031587 gocheck_do_not_annotate GO:0031584 biolink:BiologicalProcess activation of phospholipase D activity Any process that initiates the activity of inactive phospholipase D. go.json http://purl.obolibrary.org/obo/GO_0031584 gocheck_do_not_annotate GO:0031585 biolink:BiologicalProcess regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. go.json regulation of IP3 receptor activity|regulation of inositol-1,4,5-triphosphate receptor activity http://purl.obolibrary.org/obo/GO_0031585 gocheck_do_not_annotate GO:0031582 biolink:BiologicalProcess replication fork arrest at rDNA repeats A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer. go.json replication fork arrest at ribosomal DNA repeats|replication fork blocking at rDNA repeats http://purl.obolibrary.org/obo/GO_0031582 GO:0031583 biolink:BiologicalProcess phospholipase D-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase D (PLD) and a subsequent increase in the intracellular concentration of phosphatidic acid (PA). go.json G-protein signalling, phospholipase D activating pathway|activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway|phospholipase D-activating G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0031583 GO:0031580 biolink:BiologicalProcess membrane raft distribution The process that establishes the spatial arrangement of membrane rafts within a cellular membrane. go.json lipid raft distribution http://purl.obolibrary.org/obo/GO_0031580 GO:0031581 biolink:BiologicalProcess hemidesmosome assembly Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. go.json http://purl.obolibrary.org/obo/GO_0031581 GO:0031579 biolink:BiologicalProcess membrane raft organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. go.json lipid raft organization|membrane raft organisation|membrane raft organization and biogenesis http://purl.obolibrary.org/obo/GO_0031579 GO:0031577 biolink:BiologicalProcess spindle checkpoint signaling A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle. Wikipedia:Spindle_checkpoint go.json signal transduction involved in spindle checkpoint|spindle checkpoint http://purl.obolibrary.org/obo/GO_0031577 gocheck_do_not_manually_annotate GO:0031578 biolink:BiologicalProcess mitotic spindle orientation checkpoint signaling A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected. go.json SOC|SPOC|mitotic cell cycle spindle orientation checkpoint|mitotic spindle orientation checkpoint|signal transduction involved in mitotic cell cycle spindle orientation checkpoint|spindle position checkpoint http://purl.obolibrary.org/obo/GO_0031578 GO:0031575 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031575 GO:0031576 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031576 GO:0031573 biolink:BiologicalProcess mitotic intra-S DNA damage checkpoint signaling A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. go.json S-phase checkpoint|intra-S DNA damage checkpoint|mitotic intra-S DNA damage checkpoint|signal transduction involved in intra-S DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0031573 GO:0031574 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031574 GO:0031571 biolink:BiologicalProcess mitotic G1 DNA damage checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. go.json G1 DNA damage checkpoint|G1/S DNA damage checkpoint|intracellular signal transduction involved in G1 DNA damage checkpoint|intracellular signal transduction involved in G1/S DNA damage checkpoint|intracellular signal transduction pathway involved in G1 DNA damage checkpoint|intracellular signal transduction pathway involved in G1/S DNA damage checkpoint|intracellular signaling cascade involved in G1 DNA damage checkpoint|intracellular signaling cascade involved in G1/S DNA damage checkpoint|intracellular signaling chain involved in G1 DNA damage checkpoint|intracellular signaling chain involved in G1/S DNA damage checkpoint|intracellular signaling pathway involved in G1 DNA damage checkpoint|intracellular signaling pathway involved in G1/S DNA damage checkpoint|mitotic G1 DNA damage checkpoint|mitotic cell cycle G1/S transition DNA damage checkpoint|signal transduction involved in mitotic G1 DNA damage checkpoint|signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint|signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint|signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint|signal transmission via intracellular cascade involved in G1 DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0031571 GO:0031572 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031572 GO:0031570 biolink:BiologicalProcess DNA integrity checkpoint signaling A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. go.json DNA integrity checkpoint|signal transduction involved in DNA integrity checkpoint http://purl.obolibrary.org/obo/GO_0031570 GO:0031568 biolink:BiologicalProcess mitotic G1 cell size control checkpoint signaling A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle. go.json G1 cell size control checkpoint|G1 cell size control checkpoint signalling|mitotic G1 cell size control checkpoint|mitotic cell cycle G1/S transition size control checkpoint|signal transduction involved in G1 cell size control checkpoint|signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint http://purl.obolibrary.org/obo/GO_0031568 GO:0031569 biolink:BiologicalProcess mitotic G2 cell size control checkpoint signaling A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis. go.json G2 cell size control checkpoint|G2/M transition size control checkpoint|mitotic G2 cell size control checkpoint|mitotic cell cycle G2/M transition size control checkpoint|signal transduction involved in G2 cell size control checkpoint|signal transduction involved in G2/M transition size control checkpoint|signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint http://purl.obolibrary.org/obo/GO_0031569 GO:0031566 biolink:BiologicalProcess actomyosin contractile ring maturation The cellular process in which the contractile ring cytokinetic ring attains its fully functional state. go.json actomyosin contractile ring maintenance http://purl.obolibrary.org/obo/GO_0031566 GO:0031567 biolink:BiologicalProcess mitotic cell size control checkpoint signaling A signal transduction process that contributes to a cell size control checkpoint during mitosis. go.json mitotic cell cycle cell size control checkpoint|mitotic cell size control checkpoint|signal transduction involved in cell size control checkpoint http://purl.obolibrary.org/obo/GO_0031567 GO:0031564 biolink:BiologicalProcess transcription antitermination A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions. go.json transcriptional readthrough http://purl.obolibrary.org/obo/GO_0031564 GO:0031565 biolink:BiologicalProcess obsolete cytokinesis checkpoint OBSOLETE. A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition. go.json contractile ring checkpoint|septin checkpoint True http://purl.obolibrary.org/obo/GO_0031565 GO:0031562 biolink:CellularComponent hyphal tip polarisome Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha. go.json http://purl.obolibrary.org/obo/GO_0031562 GO:0031563 biolink:CellularComponent mating projection tip polarisome Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone. go.json http://purl.obolibrary.org/obo/GO_0031563 GO:0031560 biolink:CellularComponent cellular bud neck polarisome Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0031560 GO:0031561 biolink:CellularComponent cellular bud tip polarisome Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud. go.json http://purl.obolibrary.org/obo/GO_0031561 GO:0031559 biolink:MolecularActivity oxidosqualene cyclase activity Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene. go.json 2,3-oxidosqualene cyclase activity http://purl.obolibrary.org/obo/GO_0031559 GO:0031557 biolink:BiologicalProcess obsolete induction of programmed cell death in response to chemical stimulus OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus. go.json induction of programmed cell death in response to chemical stimulus|induction of programmed cell death in response to chemical substance True http://purl.obolibrary.org/obo/GO_0031557 GO:0031558 biolink:BiologicalProcess obsolete induction of apoptosis in response to chemical stimulus OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus. go.json induction of apoptosis in response to chemical stimulus|induction of apoptosis in response to chemical substance True http://purl.obolibrary.org/obo/GO_0031558 GO:0031555 biolink:BiologicalProcess transcriptional attenuation A negative regulation of gene expression mechanism by which bacteria and archae can direct RNA polymerase to prematurely terminate transcription in response to a specific metabolic signal. Wikipedia:Attenuator_(genetics) go.json http://purl.obolibrary.org/obo/GO_0031555 GO:0031556 biolink:BiologicalProcess transcriptional attenuation by ribosome A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch. go.json ribosome-mediated transcriptional attenuation http://purl.obolibrary.org/obo/GO_0031556 GO:0031553 biolink:BiologicalProcess positive regulation of brain-derived neurotrophic factor-activated receptor activity Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. go.json activation of brain-derived neurotrophic factor receptor activity|positive regulation of BDNF receptor activity|positive regulation of brain-derived neurotrophic factor receptor activity|stimulation of brain-derived neurotrophic factor receptor activity|up regulation of brain-derived neurotrophic factor receptor activity|up-regulation of brain-derived neurotrophic factor receptor activity|upregulation of brain-derived neurotrophic factor receptor activity http://purl.obolibrary.org/obo/GO_0031553 gocheck_do_not_annotate GO:0031554 biolink:BiologicalProcess regulation of termination of DNA-templated transcription Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. go.json regulation of DNA-dependent transcription, termination|regulation of DNA-templated transcription, termination|regulation of transcription termination, DNA-dependent|transcription antiterminator activity http://purl.obolibrary.org/obo/GO_0031554 GO:0031551 biolink:BiologicalProcess regulation of brain-derived neurotrophic factor-activated receptor activity Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. go.json regulation of BDNF receptor activity|regulation of brain-derived neurotrophic factor receptor activity http://purl.obolibrary.org/obo/GO_0031551 gocheck_do_not_annotate GO:0031552 biolink:BiologicalProcess negative regulation of brain-derived neurotrophic factor-activated receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. go.json down regulation of brain-derived neurotrophic factor receptor activity|down-regulation of brain-derived neurotrophic factor receptor activity|downregulation of brain-derived neurotrophic factor receptor activity|inhibition of brain-derived neurotrophic factor receptor activity|negative regulation of BDNF receptor activity|negative regulation of brain-derived neurotrophic factor receptor activity http://purl.obolibrary.org/obo/GO_0031552 gocheck_do_not_annotate GO:0031550 biolink:BiologicalProcess positive regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. go.json activation of brain-derived neurotrophic factor receptor signaling pathway|positive regulation of BDNF receptor signaling pathway|positive regulation of BDNF receptor signalling pathway|positive regulation of brain-derived neurotrophic factor receptor signalling pathway|stimulation of brain-derived neurotrophic factor receptor signaling pathway|up regulation of brain-derived neurotrophic factor receptor signaling pathway|up-regulation of brain-derived neurotrophic factor receptor signaling pathway|upregulation of brain-derived neurotrophic factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0031550 GO:0031548 biolink:BiologicalProcess regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. go.json regulation of BDNF receptor signaling pathway|regulation of BDNF receptor signalling pathway|regulation of brain-derived neurotrophic factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0031548 GO:0031549 biolink:BiologicalProcess negative regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. go.json down regulation of brain-derived neurotrophic factor receptor signaling pathway|down-regulation of brain-derived neurotrophic factor receptor signaling pathway|downregulation of brain-derived neurotrophic factor receptor signaling pathway|inhibition of brain-derived neurotrophic factor receptor signaling pathway|negative regulation of BDNF receptor signaling pathway|negative regulation of BDNF receptor signalling pathway|negative regulation of brain-derived neurotrophic factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0031549 GO:0031546 biolink:MolecularActivity brain-derived neurotrophic factor receptor binding Binding to a brain-derived neurotrophic factor receptor. go.json BDNF receptor binding|brain-derived neurotrophic factor ligand http://purl.obolibrary.org/obo/GO_0031546 GO:0031547 biolink:BiologicalProcess brain-derived neurotrophic factor receptor signaling pathway The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands. go.json BDNF receptor signaling pathway|BDNF signalling pathway|brain-derived neurotrophic factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0031547 GO:0006588 biolink:BiologicalProcess obsolete activation of tryptophan 5-monooxygenase activity OBSOLETE. The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity. go.json tryptophan hydroxylase activation True http://purl.obolibrary.org/obo/GO_0006588 GO:0031544 biolink:MolecularActivity peptidyl-proline 3-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2. Reactome:R-HSA-9630769 go.json http://purl.obolibrary.org/obo/GO_0031544 GO:0031545 biolink:MolecularActivity peptidyl-proline 4-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. RHEA:63484|Reactome:R-HSA-1234165|Reactome:R-HSA-1234166|Reactome:R-HSA-1234173|Reactome:R-HSA-1234177|Reactome:R-HSA-1234179|Reactome:R-HSA-1234181 go.json HIF-type prolyl 4-hydroxylase|prolyl 4-hydroxylase http://purl.obolibrary.org/obo/GO_0031545 GO:0006589 biolink:BiologicalProcess octopamine biosynthetic process The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. go.json octopamine anabolism|octopamine biosynthesis|octopamine formation|octopamine synthesis http://purl.obolibrary.org/obo/GO_0006589 GO:0006586 biolink:BiologicalProcess indolalkylamine metabolic process The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. go.json indolalkylamine metabolism|indolamine metabolic process|indolamine metabolism http://purl.obolibrary.org/obo/GO_0006586 GO:0006587 biolink:BiologicalProcess serotonin biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. go.json serotonin anabolism from tryptophan|serotonin formation from tryptophan|serotonin synthesis from tryptophan http://purl.obolibrary.org/obo/GO_0006587 GO:0006584 biolink:BiologicalProcess catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. go.json catecholamine metabolism http://purl.obolibrary.org/obo/GO_0006584 GO:0006585 biolink:BiologicalProcess dopamine biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine. go.json dopamine anabolism from tyrosine|dopamine formation from tyrosine|dopamine synthesis from tyrosine http://purl.obolibrary.org/obo/GO_0006585 GO:0006582 biolink:BiologicalProcess melanin metabolic process The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. go.json melanin metabolism http://purl.obolibrary.org/obo/GO_0006582 GO:0006583 biolink:BiologicalProcess melanin biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine. go.json melanin anabolism from tyrosine|melanin formation from tyrosine|melanin synthesis from tyrosine http://purl.obolibrary.org/obo/GO_0006583 GO:0006580 biolink:BiologicalProcess ethanolamine metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). go.json ethanolamine metabolism http://purl.obolibrary.org/obo/GO_0006580 GO:0006581 biolink:BiologicalProcess acetylcholine catabolic process The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. go.json acetylcholine breakdown|acetylcholine catabolism|acetylcholine degradation http://purl.obolibrary.org/obo/GO_0006581 GO:0006590 biolink:BiologicalProcess thyroid hormone generation The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. go.json http://purl.obolibrary.org/obo/GO_0006590 GO:0031542 biolink:BiologicalProcess positive regulation of anthocyanin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. go.json activation of anthocyanin biosynthetic process|positive regulation of anthocyanin anabolism|positive regulation of anthocyanin biosynthesis|positive regulation of anthocyanin formation|positive regulation of anthocyanin synthesis|stimulation of anthocyanin biosynthetic process|up regulation of anthocyanin biosynthetic process|up-regulation of anthocyanin biosynthetic process|upregulation of anthocyanin biosynthetic process http://purl.obolibrary.org/obo/GO_0031542 GO:0031543 biolink:MolecularActivity peptidyl-proline dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. go.json proline hydroxylase activity|proline,2-oxoglutarate 4-dioxygenase activity|prolyl 4-hydroxylase activity|prolyl hydroxylase activity http://purl.obolibrary.org/obo/GO_0031543 GO:0031540 biolink:BiologicalProcess regulation of anthocyanin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. go.json regulation of anthocyanin anabolism|regulation of anthocyanin biosynthesis|regulation of anthocyanin formation|regulation of anthocyanin synthesis http://purl.obolibrary.org/obo/GO_0031540 GO:0031541 biolink:BiologicalProcess negative regulation of anthocyanin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. go.json down regulation of anthocyanin biosynthetic process|down-regulation of anthocyanin biosynthetic process|downregulation of anthocyanin biosynthetic process|inhibition of anthocyanin biosynthetic process|negative regulation of anthocyanin anabolism|negative regulation of anthocyanin biosynthesis|negative regulation of anthocyanin formation|negative regulation of anthocyanin synthesis http://purl.obolibrary.org/obo/GO_0031541 GO:0031539 biolink:BiologicalProcess positive regulation of anthocyanin metabolic process Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. go.json activation of anthocyanin metabolic process|positive regulation of anthocyanin metabolism|stimulation of anthocyanin metabolic process|up regulation of anthocyanin metabolic process|up-regulation of anthocyanin metabolic process|upregulation of anthocyanin metabolic process http://purl.obolibrary.org/obo/GO_0031539 GO:0031537 biolink:BiologicalProcess regulation of anthocyanin metabolic process Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. go.json regulation of anthocyanin metabolism http://purl.obolibrary.org/obo/GO_0031537 GO:0031538 biolink:BiologicalProcess negative regulation of anthocyanin metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. go.json down regulation of anthocyanin metabolic process|down-regulation of anthocyanin metabolic process|downregulation of anthocyanin metabolic process|inhibition of anthocyanin metabolic process|negative regulation of anthocyanin metabolism http://purl.obolibrary.org/obo/GO_0031538 GO:0031535 biolink:BiologicalProcess plus-end directed microtubule sliding The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules. go.json http://purl.obolibrary.org/obo/GO_0031535 GO:0031536 biolink:BiologicalProcess positive regulation of exit from mitosis Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). go.json activation of exit from mitosis|stimulation of exit from mitosis|up regulation of exit from mitosis|up-regulation of exit from mitosis|upregulation of exit from mitosis http://purl.obolibrary.org/obo/GO_0031536 GO:0006599 biolink:BiologicalProcess phosphagen metabolic process The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. go.json phosphagen metabolism http://purl.obolibrary.org/obo/GO_0006599 GO:0031533 biolink:CellularComponent mRNA cap methyltransferase complex A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. go.json mRNA (guanine-N7) methyltransferase complex|mRNA capping enzyme complex http://purl.obolibrary.org/obo/GO_0031533 GO:0031534 biolink:BiologicalProcess minus-end directed microtubule sliding The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules. go.json http://purl.obolibrary.org/obo/GO_0031534 GO:0006597 biolink:BiologicalProcess spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. go.json spermine anabolism|spermine biosynthesis|spermine formation|spermine synthesis http://purl.obolibrary.org/obo/GO_0006597 GO:0006598 biolink:BiologicalProcess polyamine catabolic process The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. go.json polyamine breakdown|polyamine catabolism|polyamine degradation http://purl.obolibrary.org/obo/GO_0006598 GO:0006595 biolink:BiologicalProcess polyamine metabolic process The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. go.json polyamine metabolism http://purl.obolibrary.org/obo/GO_0006595 goslim_drosophila GO:0006596 biolink:BiologicalProcess polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. MetaCyc:POLYAMSYN-PWY go.json polyamine anabolism|polyamine biosynthesis|polyamine formation|polyamine synthesis http://purl.obolibrary.org/obo/GO_0006596 GO:0006593 biolink:BiologicalProcess ornithine catabolic process The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. go.json ornithine breakdown|ornithine catabolism|ornithine degradation http://purl.obolibrary.org/obo/GO_0006593 GO:0006594 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006594 GO:0006591 biolink:BiologicalProcess ornithine metabolic process The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. go.json ornithine metabolism http://purl.obolibrary.org/obo/GO_0006591 GO:0006592 biolink:BiologicalProcess ornithine biosynthetic process The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. go.json ornithine anabolism|ornithine biosynthesis|ornithine formation|ornithine synthesis http://purl.obolibrary.org/obo/GO_0006592 GO:0031531 biolink:MolecularActivity thyrotropin-releasing hormone receptor binding Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. go.json thyrotropin releasing hormone receptor binding|thyrotropin-releasing hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031531 GO:0031532 biolink:BiologicalProcess obsolete actin cytoskeleton reorganization OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. go.json actin cytoskeleton remodeling|actin cytoskeleton reorganisation True http://purl.obolibrary.org/obo/GO_0031532 GO:0031530 biolink:MolecularActivity gonadotropin-releasing hormone receptor binding Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. go.json GnRH receptor binding|gonadotrophin-releasing hormone receptor binding http://purl.obolibrary.org/obo/GO_0031530 GO:0031528 biolink:CellularComponent microvillus membrane The portion of the plasma membrane surrounding a microvillus. go.json http://purl.obolibrary.org/obo/GO_0031528 GO:0031529 biolink:BiologicalProcess ruffle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. go.json ruffle organisation|ruffle organization and biogenesis http://purl.obolibrary.org/obo/GO_0031529 GO:0031526 biolink:CellularComponent brush border membrane The portion of the plasma membrane surrounding the brush border. go.json http://purl.obolibrary.org/obo/GO_0031526 GO:0031527 biolink:CellularComponent filopodium membrane The portion of the plasma membrane surrounding a filopodium. go.json http://purl.obolibrary.org/obo/GO_0031527 GO:0006568 biolink:BiologicalProcess tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. Wikipedia:Tryptophan go.json tryptophan metabolism http://purl.obolibrary.org/obo/GO_0006568 GO:0031524 biolink:BiologicalProcess menthol metabolic process The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol. go.json menthol metabolism http://purl.obolibrary.org/obo/GO_0031524 GO:0006569 biolink:BiologicalProcess tryptophan catabolic process The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. go.json tryptophan breakdown|tryptophan catabolic process, using tryptophanase|tryptophan catabolism|tryptophan catabolism, using tryptophanase|tryptophan degradation http://purl.obolibrary.org/obo/GO_0006569 GO:0031525 biolink:BiologicalProcess menthol biosynthetic process The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol. go.json menthol anabolism|menthol biosynthesis|menthol formation|menthol synthesis http://purl.obolibrary.org/obo/GO_0031525 GO:0006566 biolink:BiologicalProcess threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. UM-BBD_pathwayID:met go.json methionine and threonine metabolic process|methionine and threonine metabolism|threonine metabolism http://purl.obolibrary.org/obo/GO_0006566 GO:0031522 biolink:CellularComponent cell envelope Sec protein transport complex A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC. go.json Sec complex|Sec secretion complex|Sec translocation complex|plasma membrane Sec complex http://purl.obolibrary.org/obo/GO_0031522 GO:0006567 biolink:BiologicalProcess threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. MetaCyc:THREOCAT-PWY|UM-BBD_pathwayID:met go.json threonine breakdown|threonine catabolism|threonine degradation http://purl.obolibrary.org/obo/GO_0006567 GO:0031523 biolink:CellularComponent Myb complex A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression. go.json Myeloblastosis proto-oncogene protein complex http://purl.obolibrary.org/obo/GO_0031523 GO:0006564 biolink:BiologicalProcess L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. MetaCyc:SERSYN-PWY go.json L-serine anabolism|L-serine biosynthesis|L-serine formation|L-serine synthesis http://purl.obolibrary.org/obo/GO_0006564 GO:0006565 biolink:BiologicalProcess L-serine catabolic process The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. MetaCyc:SERDEG-PWY go.json L-serine breakdown|L-serine catabolism|L-serine degradation http://purl.obolibrary.org/obo/GO_0006565 GO:0006562 biolink:BiologicalProcess proline catabolic process The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. go.json proline breakdown|proline catabolism|proline degradation http://purl.obolibrary.org/obo/GO_0006562 GO:0006563 biolink:BiologicalProcess L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. go.json L-serine metabolism http://purl.obolibrary.org/obo/GO_0006563 GO:0006560 biolink:BiologicalProcess proline metabolic process The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. go.json proline metabolism http://purl.obolibrary.org/obo/GO_0006560 GO:0006561 biolink:BiologicalProcess proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. MetaCyc:PROSYN-PWY|MetaCyc:PWY-3341 go.json proline anabolism|proline biosynthesis|proline formation|proline synthesis http://purl.obolibrary.org/obo/GO_0006561 GO:0031520 biolink:CellularComponent plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip. go.json 'plasma membrane, cell tip' http://purl.obolibrary.org/obo/GO_0031520 GO:0031521 biolink:CellularComponent spitzenkorper Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments. go.json http://purl.obolibrary.org/obo/GO_0031521 GO:0031517 biolink:MolecularActivity red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation. go.json http://purl.obolibrary.org/obo/GO_0031517 GO:0031518 biolink:CellularComponent CBF3 complex A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p. go.json http://purl.obolibrary.org/obo/GO_0031518 GO:0031515 biolink:CellularComponent tRNA (m1A) methyltransferase complex A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. go.json http://purl.obolibrary.org/obo/GO_0031515 GO:0031516 biolink:MolecularActivity far-red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation. go.json http://purl.obolibrary.org/obo/GO_0031516 GO:0031513 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031513 GO:0006579 biolink:BiologicalProcess amino-acid betaine catabolic process The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid. go.json betaine breakdown|betaine catabolic process|betaine catabolism|betaine degradation http://purl.obolibrary.org/obo/GO_0006579 GO:0031514 biolink:CellularComponent motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. go.json microtubule-based flagellum|motile cilia|motile primary cilia|motile primary cilium|motile secondary cilium|nodal cilium http://purl.obolibrary.org/obo/GO_0031514 GO:0006577 biolink:BiologicalProcess amino-acid betaine metabolic process The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. go.json betaine metabolic process|betaine metabolism http://purl.obolibrary.org/obo/GO_0006577 GO:0031511 biolink:CellularComponent Mis6-Sim4 complex A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. go.json Mcm21|Mis6 centromere subcomplex|Mis6-Mal2-Sim4 centromere complex|Sim4 complex http://purl.obolibrary.org/obo/GO_0031511 GO:0031512 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031512 GO:0006578 biolink:BiologicalProcess amino-acid betaine biosynthetic process The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid. go.json betaine anabolism|betaine biosynthesis|betaine biosynthetic process|betaine formation|betaine synthesis http://purl.obolibrary.org/obo/GO_0006578 GO:0006575 biolink:BiologicalProcess cellular modified amino acid metabolic process The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. go.json amino acid derivative metabolic process|cellular amino acid derivative metabolic process|cellular amino acid derivative metabolism|cellular modified amino acid metabolism|modified amino acid metabolic process|modified amino acid metabolism http://purl.obolibrary.org/obo/GO_0006575 goslim_drosophila|goslim_generic|prokaryote_subset GO:0006576 biolink:BiologicalProcess biogenic amine metabolic process The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. go.json biogenic amine metabolism|cellular biogenic amine metabolic process http://purl.obolibrary.org/obo/GO_0006576 GO:0006573 biolink:BiologicalProcess valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. go.json valine metabolism http://purl.obolibrary.org/obo/GO_0006573 GO:0006574 biolink:BiologicalProcess valine catabolic process The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. MetaCyc:VALDEG-PWY go.json valine breakdown|valine catabolism|valine degradation http://purl.obolibrary.org/obo/GO_0006574 GO:0006571 biolink:BiologicalProcess tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. go.json tyrosine anabolism|tyrosine biosynthesis|tyrosine formation|tyrosine synthesis http://purl.obolibrary.org/obo/GO_0006571 GO:0006572 biolink:BiologicalProcess tyrosine catabolic process The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. go.json tyrosine breakdown|tyrosine catabolism|tyrosine degradation http://purl.obolibrary.org/obo/GO_0006572 GO:0031519 biolink:CellularComponent PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. go.json Polycomb Group protein complex http://purl.obolibrary.org/obo/GO_0031519 goslim_pir GO:0006570 biolink:BiologicalProcess tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. UM-BBD_pathwayID:tyr|Wikipedia:Tyrosine go.json tyrosine metabolism http://purl.obolibrary.org/obo/GO_0006570 GO:0031510 biolink:CellularComponent SUMO activating enzyme complex A conserved heterodimeric complex with SUMO activating enzyme activity. go.json SAE|SUMO E1 activator enzyme complex http://purl.obolibrary.org/obo/GO_0031510 OIO:hasOBONamespace biolink:OntologyClass has_obo_namespace go.json http://www.geneontology.org/formats/oboInOwl#hasOBONamespace GO:0031599 biolink:CellularComponent obsolete ER proteasome regulatory particle OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031599 GO:0031590 biolink:BiologicalProcess wybutosine metabolic process The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. go.json wybutosine metabolism|yW metabolic process|yW metabolism http://purl.obolibrary.org/obo/GO_0031590 GO:0031597 biolink:CellularComponent cytosolic proteasome complex A proteasome complex found in the cytosol of a cell. go.json http://purl.obolibrary.org/obo/GO_0031597 GO:0031598 biolink:CellularComponent nuclear proteasome regulatory particle The regulatory subcomplex of a proteasome located in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031598 GO:0031595 biolink:CellularComponent nuclear proteasome complex A proteasome found in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031595 GO:0031596 biolink:CellularComponent obsolete ER proteasome complex OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031596 GO:0031593 biolink:MolecularActivity polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination of the target protein. go.json http://purl.obolibrary.org/obo/GO_0031593 GO:0031594 biolink:CellularComponent neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. NIF_Subcellular:sao1124888485|Wikipedia:Neuromuscular_junction go.json NMJ|motor endplate http://purl.obolibrary.org/obo/GO_0031594 GO:0031591 biolink:BiologicalProcess wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. go.json yW biosynthesis|yW biosynthetic process http://purl.obolibrary.org/obo/GO_0031591 GO:0031592 biolink:CellularComponent centrosomal corona An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin. go.json http://purl.obolibrary.org/obo/GO_0031592 GO:0031506 biolink:BiologicalProcess cell wall glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues. go.json cell wall glycoprotein anabolism|cell wall glycoprotein biosynthesis|cell wall glycoprotein formation|cell wall glycoprotein synthesis http://purl.obolibrary.org/obo/GO_0031506 GO:0031507 biolink:BiologicalProcess heterochromatin formation An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. go.json TGS|chromatin silencing|chromatin-mediated silencing|establishment of chromatin silencing|establishment of heterochromatic silencing|establishment of heterochromatin architecture|establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region|establishment of heterochromatin architecture involved in chromatin silencing at pericentric region|heterochromatic silencing|heterochromatin assembly|heterochromatin assembly involved in chromatin silencing|heterochromatin assembly involved in chromatin silencing at centromere outer repeat region|heterochromatin assembly involved in chromatin silencing at pericentric region|heterochromatin formation involved in chromatin silencing|heterochromatin formation involved in chromatin silencing at centromere outer repeat region|heterochromatin formation involved in chromatin silencing at pericentric region|heterochromatin maintenance|transcriptional gene silencing http://purl.obolibrary.org/obo/GO_0031507 GO:0006548 biolink:BiologicalProcess histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. go.json histidine breakdown|histidine catabolism|histidine degradation http://purl.obolibrary.org/obo/GO_0006548 GO:0031504 biolink:BiologicalProcess peptidoglycan-based cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall. go.json peptidoglycan-based cell wall organisation|peptidoglycan-based cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0031504 GO:0006549 biolink:BiologicalProcess isoleucine metabolic process The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. go.json isoleucine metabolism http://purl.obolibrary.org/obo/GO_0006549 GO:0031505 biolink:BiologicalProcess fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall. go.json beta-glucan-containing cell wall organization and biogenesis|chitin- and beta-glucan-containing cell wall organisation|chitin- and beta-glucan-containing cell wall organization and biogenesis|chitin-containing cell wall organization and biogenesis|fungal-type cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0031505 GO:0006546 biolink:BiologicalProcess glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. go.json glycine breakdown|glycine catabolism|glycine degradation http://purl.obolibrary.org/obo/GO_0006546 GO:0031502 biolink:CellularComponent dolichyl-phosphate-mannose-protein mannosyltransferase complex A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies. go.json PMT family mannosyltransferase complex|protein O-mannosyltransferase complex http://purl.obolibrary.org/obo/GO_0031502 GO:0031503 biolink:BiologicalProcess protein-containing complex localization A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. go.json cellular protein complex localisation|cellular protein complex localization|cellular protein-containing complex localization|establishment and maintenance of cellular protein complex localization|establishment and maintenance of protein complex localization|protein complex localisation|protein complex localization http://purl.obolibrary.org/obo/GO_0031503 GO:0006547 biolink:BiologicalProcess histidine metabolic process The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. Wikipedia:Histidine go.json histidine metabolism http://purl.obolibrary.org/obo/GO_0006547 GO:0031500 biolink:CellularComponent Tea1 cell-end complex A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity. go.json http://purl.obolibrary.org/obo/GO_0031500 GO:0006544 biolink:BiologicalProcess glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. go.json glycine metabolism http://purl.obolibrary.org/obo/GO_0006544 GO:0006545 biolink:BiologicalProcess glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. MetaCyc:GLYCINE-SYN2-PWY go.json glycine anabolism|glycine biosynthesis|glycine formation|glycine synthesis http://purl.obolibrary.org/obo/GO_0006545 GO:0031501 biolink:CellularComponent mannosyltransferase complex A complex that posseses mannosyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0031501 goslim_pir GO:0006542 biolink:BiologicalProcess glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. MetaCyc:GLNSYN-PWY go.json glutamine anabolism|glutamine biosynthesis|glutamine formation|glutamine synthesis http://purl.obolibrary.org/obo/GO_0006542 GO:0006543 biolink:BiologicalProcess glutamine catabolic process The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. go.json glutamine breakdown|glutamine catabolism|glutamine degradation http://purl.obolibrary.org/obo/GO_0006543 GO:0006540 biolink:BiologicalProcess glutamate decarboxylation to succinate The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. MetaCyc:GLUDEG-I-PWY go.json 4-aminobutyrate shunt|GABA shunt|degradation of glutamate to succinate through GABA|gamma-aminobutyrate shunt|glutamate degradation via 4-aminobutyrate|glutamate degradation via GABA http://purl.obolibrary.org/obo/GO_0006540 GO:0006541 biolink:BiologicalProcess glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. go.json glutamine metabolism http://purl.obolibrary.org/obo/GO_0006541 GO:0031508 biolink:BiologicalProcess pericentric heterochromatin formation The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA. go.json centric heterochromatin formation|centromere chromatin silencing|centromeric heterochromatin biosynthesis|centromeric heterochromatin formation|centromeric silencing|chromatin silencing at centromere|chromatin silencing at centromere outer repeat region|chromatin silencing at pericentric region|heterochromatic silencing at centromere|pericentric heterochromatin assembly http://purl.obolibrary.org/obo/GO_0031508 GO:0031509 biolink:BiologicalProcess subtelomeric heterochromatin formation The compaction of chromatin into heterochromatin at the subtelomeric region. go.json Telomere Position Effect|chromatin silencing at subtelomere|chromatin silencing at telomere|establishment of chromatin silencing at telomere|heterochromatic silencing at subtelomere|heterochromatic silencing at telomere|regulation of chromatin silencing at telomere|regulation of subtelomeric heterochromatin assembly|subtelomere chromatin silencing|subtelomeric heterochromatin assembly|subtelomeric silencing|telomere chromatin silencing|telomeric heterochromatin assembly|telomeric heterochromatin formation|telomeric silencing http://purl.obolibrary.org/obo/GO_0031509 GO:0006559 biolink:BiologicalProcess L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. go.json L-phenylalanine breakdown|L-phenylalanine catabolism|L-phenylalanine degradation|phenylalanine catabolic process|phenylalanine catabolism http://purl.obolibrary.org/obo/GO_0006559 GO:0006557 biolink:BiologicalProcess obsolete S-adenosylmethioninamine biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. go.json S-adenosylmethioninamine anabolism|S-adenosylmethioninamine biosynthesis|S-adenosylmethioninamine formation|S-adenosylmethioninamine synthesis True http://purl.obolibrary.org/obo/GO_0006557 GO:0006558 biolink:BiologicalProcess L-phenylalanine metabolic process The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. go.json L-phenylalanine metabolism|phenylalanine metabolic process|phenylalanine metabolism http://purl.obolibrary.org/obo/GO_0006558 GO:0006555 biolink:BiologicalProcess methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. UM-BBD_pathwayID:met go.json methionine and threonine metabolic process|methionine and threonine metabolism|methionine metabolism http://purl.obolibrary.org/obo/GO_0006555 GO:0006556 biolink:BiologicalProcess S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. MetaCyc:SAM-PWY go.json S-adenosyl methionine biosynthesis|S-adenosyl methionine biosynthetic process|S-adenosylmethionine anabolism|S-adenosylmethionine biosynthesis|S-adenosylmethionine formation|S-adenosylmethionine synthesis|SAM biosynthetic process http://purl.obolibrary.org/obo/GO_0006556 GO:0006553 biolink:BiologicalProcess lysine metabolic process The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. Wikipedia:Lysine go.json lysine metabolism http://purl.obolibrary.org/obo/GO_0006553 GO:0006554 biolink:BiologicalProcess lysine catabolic process The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. go.json lysine breakdown|lysine catabolism|lysine degradation http://purl.obolibrary.org/obo/GO_0006554 GO:0006551 biolink:BiologicalProcess leucine metabolic process The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid. go.json leucine metabolism http://purl.obolibrary.org/obo/GO_0006551 GO:0006552 biolink:BiologicalProcess leucine catabolic process The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. MetaCyc:LEU-DEG2-PWY go.json leucine breakdown|leucine catabolism|leucine degradation http://purl.obolibrary.org/obo/GO_0006552 GO:0006550 biolink:BiologicalProcess isoleucine catabolic process The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. MetaCyc:ILEUDEG-PWY go.json isoleucine breakdown|isoleucine catabolism|isoleucine degradation http://purl.obolibrary.org/obo/GO_0006550 GO:0006528 biolink:BiologicalProcess asparagine metabolic process The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid. MetaCyc:ASPARAGINESYN-PWY go.json asparagine metabolism http://purl.obolibrary.org/obo/GO_0006528 GO:0006529 biolink:BiologicalProcess asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. go.json asparagine anabolism|asparagine biosynthesis|asparagine formation|asparagine synthesis http://purl.obolibrary.org/obo/GO_0006529 GO:0006526 biolink:BiologicalProcess arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. MetaCyc:ARGININE-SYN4-PWY|MetaCyc:ARGSYN-PWY|MetaCyc:ARGSYNBSUB-PWY go.json arginine anabolism|arginine biosynthesis|arginine formation|arginine synthesis http://purl.obolibrary.org/obo/GO_0006526 GO:0006527 biolink:BiologicalProcess arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. go.json arginine breakdown|arginine catabolism|arginine degradation http://purl.obolibrary.org/obo/GO_0006527 GO:0006524 biolink:BiologicalProcess alanine catabolic process The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. go.json alanine breakdown|alanine catabolism|alanine degradation http://purl.obolibrary.org/obo/GO_0006524 GO:0006525 biolink:BiologicalProcess arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. Wikipedia:Arginine go.json arginine metabolism http://purl.obolibrary.org/obo/GO_0006525 GO:0006522 biolink:BiologicalProcess alanine metabolic process The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. go.json alanine metabolism http://purl.obolibrary.org/obo/GO_0006522 GO:0006523 biolink:BiologicalProcess alanine biosynthetic process The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. go.json alanine anabolism|alanine biosynthesis|alanine formation|alanine synthesis http://purl.obolibrary.org/obo/GO_0006523 GO:0006520 biolink:BiologicalProcess amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. go.json amino acid and derivative metabolism|cellular amino acid and derivative metabolic process|cellular amino acid metabolic process|cellular amino acid metabolism http://purl.obolibrary.org/obo/GO_0006520 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast|prokaryote_subset GO:0006521 biolink:BiologicalProcess regulation of cellular amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. go.json regulation of amino acid metabolism http://purl.obolibrary.org/obo/GO_0006521 GO:0006539 biolink:BiologicalProcess glutamate catabolic process via 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate. MetaCyc:P162-PWY go.json glutamate breakdown via 2-oxoglutarate|glutamate catabolic process via 2-ketoglutarate|glutamate catabolic process via alpha-ketoglutarate|glutamate catabolic process via alpha-oxoglutarate|glutamate catabolism via 2-ketoglutarate|glutamate catabolism via alpha-ketoglutarate|glutamate catabolism via alpha-oxoglutarate|glutamate degradation via 2-oxoglutarate http://purl.obolibrary.org/obo/GO_0006539 GO:0006537 biolink:BiologicalProcess glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. go.json glutamate anabolism|glutamate biosynthesis|glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)|glutamate biosynthesis, using glutamate synthase (NADPH)|glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)|glutamate biosynthetic process, using glutamate synthase (NADPH)|glutamate formation|glutamate synthesis|glutamic acid biosynthesis|glutamic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0006537 GO:0006538 biolink:BiologicalProcess glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. go.json glutamate breakdown|glutamate catabolism|glutamate deamidation|glutamate degradation|glutamic acid catabolic process|glutamic acid catabolism http://purl.obolibrary.org/obo/GO_0006538 GO:0006535 biolink:BiologicalProcess cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. MetaCyc:CYSTSYN-PWY go.json cysteine anabolism from serine|cysteine formation from serine|cysteine synthesis from serine http://purl.obolibrary.org/obo/GO_0006535 GO:0006536 biolink:BiologicalProcess glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. Wikipedia:Glutamic_acid go.json glutamate metabolism|glutamic acid metabolic process|glutamic acid metabolism http://purl.obolibrary.org/obo/GO_0006536 GO:0006533 biolink:BiologicalProcess aspartate catabolic process The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. go.json aspartate breakdown|aspartate catabolism|aspartate degradation http://purl.obolibrary.org/obo/GO_0006533 GO:0006534 biolink:BiologicalProcess cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. Wikipedia:Cysteine_metabolism go.json cysteine metabolism http://purl.obolibrary.org/obo/GO_0006534 GO:0006531 biolink:BiologicalProcess aspartate metabolic process The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. go.json aspartate metabolism http://purl.obolibrary.org/obo/GO_0006531 GO:0006532 biolink:BiologicalProcess aspartate biosynthetic process The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. go.json aspartate anabolism|aspartate biosynthesis|aspartate formation|aspartate synthesis http://purl.obolibrary.org/obo/GO_0006532 GO:0006530 biolink:BiologicalProcess asparagine catabolic process The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid. go.json asparagine breakdown|asparagine catabolism|asparagine degradation http://purl.obolibrary.org/obo/GO_0006530 IAO:0000700 biolink:OntologyClass has ontology root term IAO:0000700 go.json http://purl.obolibrary.org/obo/IAO_0000700 GO:0006506 biolink:BiologicalProcess GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. go.json GPI anchor anabolism|GPI anchor biosynthesis|GPI anchor formation|GPI anchor synthesis|GPI/GSI anchor biosynthesis|GPI/GSI anchor biosynthetic process|glycosylphosphatidylinositol biosynthesis|glycosylphosphatidylinositol biosynthetic process http://purl.obolibrary.org/obo/GO_0006506 GO:0006507 biolink:BiologicalProcess GPI anchor release The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane. go.json http://purl.obolibrary.org/obo/GO_0006507 GO:0006504 biolink:BiologicalProcess obsolete C-terminal protein geranylgeranylation OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy-terminus of a protein. go.json C-terminal protein geranylgeranylation True http://purl.obolibrary.org/obo/GO_0006504 GO:0006505 biolink:BiologicalProcess GPI anchor metabolic process The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. go.json GPI anchor metabolism|GPI/GSI anchor metabolic process|GPI/GSI anchor metabolism|glycosylphosphatidylinositol metabolic process|glycosylphosphatidylinositol metabolism http://purl.obolibrary.org/obo/GO_0006505 GO:0006502 biolink:BiologicalProcess obsolete C-terminal protein prenylation OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy-terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added. go.json C-terminal protein prenylation True http://purl.obolibrary.org/obo/GO_0006502 GO:0006503 biolink:BiologicalProcess obsolete C-terminal protein farnesylation OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein. go.json C-terminal protein farnesylation True http://purl.obolibrary.org/obo/GO_0006503 GO:0006500 biolink:BiologicalProcess N-terminal protein palmitoylation The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0006500 gocheck_do_not_annotate GO:0006501 biolink:BiologicalProcess C-terminal protein lipidation The covalent attachment of a lipid group to the carboxy-terminus of a protein. go.json http://purl.obolibrary.org/obo/GO_0006501 gocheck_do_not_annotate GO:0006508 biolink:BiologicalProcess proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. Wikipedia:Proteolysis go.json ATP-dependent proteolysis|peptidolysis http://purl.obolibrary.org/obo/GO_0006508 goslim_chembl|goslim_metagenomics|goslim_pir GO:0006509 biolink:BiologicalProcess membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). go.json ectoderm shedding|ectodomain cleavage|membrane protein solubilization|receptor shedding http://purl.obolibrary.org/obo/GO_0006509 GO:0006517 biolink:BiologicalProcess protein deglycosylation The removal of sugar residues from a glycosylated protein. go.json glycoprotein deglycosylation http://purl.obolibrary.org/obo/GO_0006517 gocheck_do_not_annotate GO:0006518 biolink:BiologicalProcess peptide metabolic process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. go.json peptide metabolism http://purl.obolibrary.org/obo/GO_0006518 goslim_pir GO:0006515 biolink:BiologicalProcess protein quality control for misfolded or incompletely synthesized proteins The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. go.json degradation of misfolded or incompletely synthesized proteins|misfolded or incompletely synthesized protein breakdown|misfolded or incompletely synthesized protein catabolic process|misfolded or incompletely synthesized protein catabolism|misfolded or incompletely synthesized protein degradation|protein quality control (PQC)|protein quality control by the ubiquitin-proteasome system http://purl.obolibrary.org/obo/GO_0006515 GO:0006516 biolink:BiologicalProcess glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. go.json glycoprotein breakdown|glycoprotein catabolism|glycoprotein degradation http://purl.obolibrary.org/obo/GO_0006516 GO:0006513 biolink:BiologicalProcess protein monoubiquitination Addition of a single ubiquitin group to a protein. go.json protein monoubiquitinylation|protein monoubiquitylation http://purl.obolibrary.org/obo/GO_0006513 GO:0006514 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006514 GO:0006511 biolink:BiologicalProcess ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. go.json myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown|myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process|myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism|myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation|protein degradation tagging activity|protein ubiquitination during ubiquitin-dependent protein breakdown|protein ubiquitination during ubiquitin-dependent protein catabolic process|protein ubiquitination during ubiquitin-dependent protein catabolism|protein ubiquitination during ubiquitin-dependent protein degradation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitinylation during ubiquitin-dependent protein catabolic process|protein ubiquitinylation during ubiquitin-dependent protein catabolism|protein ubiquitylation during ubiquitin-dependent protein catabolic process|protein ubiquitylation during ubiquitin-dependent protein catabolism|ubiquitin-dependent protein breakdown|ubiquitin-dependent protein catabolism|ubiquitin-dependent protein degradation|ubiquitin-dependent proteolysis http://purl.obolibrary.org/obo/GO_0006511 GO:0006512 biolink:BiologicalProcess obsolete ubiquitin cycle OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein. go.json ubiquitin cycle True http://purl.obolibrary.org/obo/GO_0006512 GO:0006510 biolink:BiologicalProcess obsolete ATP-dependent proteolysis OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP. go.json ATP-dependent peptidolysis|ATP-dependent proteolysis True http://purl.obolibrary.org/obo/GO_0006510 GO:0006519 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006519 GO:0016070 biolink:BiologicalProcess RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. go.json RNA metabolism http://purl.obolibrary.org/obo/GO_0016070 goslim_agr|goslim_candida|goslim_metagenomics|goslim_pir|prokaryote_subset GO:0016071 biolink:BiologicalProcess mRNA metabolic process The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. go.json mRNA metabolism http://purl.obolibrary.org/obo/GO_0016071 goslim_drosophila|goslim_generic|goslim_pombe|prokaryote_subset GO:0016072 biolink:BiologicalProcess rRNA metabolic process The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. go.json rRNA metabolism http://purl.obolibrary.org/obo/GO_0016072 goslim_drosophila GO:0065001 biolink:BiologicalProcess specification of axis polarity The pattern specification process in which the polarity of a body or organ axis is established and maintained. go.json http://purl.obolibrary.org/obo/GO_0065001 GO:0065004 biolink:BiologicalProcess protein-DNA complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. go.json DNA-protein complex assembly http://purl.obolibrary.org/obo/GO_0065004 GO:0065005 biolink:BiologicalProcess protein-lipid complex assembly The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. go.json http://purl.obolibrary.org/obo/GO_0065005 GO:0065002 biolink:BiologicalProcess intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. go.json intracellular membrane translocation of a protein|intracellular protein membrane transport|intracellular protein transport across a membrane http://purl.obolibrary.org/obo/GO_0065002 GO:0065003 biolink:BiologicalProcess protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. go.json cellular macromolecule complex assembly|cellular protein complex assembly|cellular protein-containing complex assembly|chaperone activity|macromolecular complex assembly|macromolecule complex assembly|protein complex assembly|protein complex formation http://purl.obolibrary.org/obo/GO_0065003 goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_pombe|prokaryote_subset GO:0065008 biolink:BiologicalProcess regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. go.json regulation of biological attribute|regulation of biological characteristic http://purl.obolibrary.org/obo/GO_0065008 goslim_pir GO:0065009 biolink:BiologicalProcess regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. go.json regulation of a molecular function http://purl.obolibrary.org/obo/GO_0065009 gocheck_do_not_annotate|goslim_pir|goslim_plant GO:0065006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0065006 GO:0065007 biolink:BiologicalProcess biological regulation Any process that modulates a measurable attribute of any biological process, quality or function. go.json regulation http://purl.obolibrary.org/obo/GO_0065007 gocheck_do_not_annotate|goslim_pir GO:0016066 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016066 GO:0016067 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016067 GO:0016068 biolink:BiologicalProcess type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. Wikipedia:Type_I_hypersensitivity go.json immediate hypersensitivity response http://purl.obolibrary.org/obo/GO_0016068 GO:0016069 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016069 GO:0016062 biolink:BiologicalProcess adaptation of rhodopsin mediated signaling The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation. go.json adaptation of rhodopsin mediated signalling http://purl.obolibrary.org/obo/GO_0016062 GO:0016063 biolink:BiologicalProcess rhodopsin biosynthetic process The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. go.json rhodopsin anabolism|rhodopsin biosynthesis|rhodopsin formation|rhodopsin synthesis http://purl.obolibrary.org/obo/GO_0016063 GO:0016064 biolink:BiologicalProcess immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution. go.json antibody-mediated immune response http://purl.obolibrary.org/obo/GO_0016064 GO:0016065 biolink:BiologicalProcess obsolete humoral defense mechanism (sensu Protostomia) OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). go.json humoral defence mechanism (sensu Protostomia)|humoral defense mechanism (sensu Protostomia) True http://purl.obolibrary.org/obo/GO_0016065 GO:0016080 biolink:BiologicalProcess synaptic vesicle targeting The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. go.json http://purl.obolibrary.org/obo/GO_0016080 GO:0016081 biolink:BiologicalProcess synaptic vesicle docking The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. go.json synaptic vesicle docking during exocytosis|synaptic vesicle docking involved in exocytosis http://purl.obolibrary.org/obo/GO_0016081 goslim_synapse GO:0016082 biolink:BiologicalProcess synaptic vesicle priming A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. go.json http://purl.obolibrary.org/obo/GO_0016082 goslim_synapse GO:0016083 biolink:BiologicalProcess obsolete synaptic vesicle fusion OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane. go.json synaptic vesicle fusion True http://purl.obolibrary.org/obo/GO_0016083 GO:0031698 biolink:MolecularActivity beta-2 adrenergic receptor binding Binding to a beta-2 adrenergic receptor. go.json beta-2 adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031698 GO:0031699 biolink:MolecularActivity beta-3 adrenergic receptor binding Binding to a beta-3 adrenergic receptor. go.json beta-3 adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031699 GO:0016077 biolink:BiologicalProcess sno(s)RNA catabolic process The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. go.json sRNA catabolic process|sno(s)RNA breakdown|sno(s)RNA catabolism|sno(s)RNA degradation|snoRNA catabolic process http://purl.obolibrary.org/obo/GO_0016077 GO:0031696 biolink:MolecularActivity alpha-2C adrenergic receptor binding Binding to an alpha-2C adrenergic receptor. go.json alpha-2C adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031696 GO:0031697 biolink:MolecularActivity beta-1 adrenergic receptor binding Binding to a beta-1 adrenergic receptor. go.json beta-1 adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031697 GO:0016078 biolink:BiologicalProcess tRNA catabolic process The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. go.json tRNA breakdown|tRNA catabolism|tRNA degradation http://purl.obolibrary.org/obo/GO_0016078 GO:0016079 biolink:BiologicalProcess synaptic vesicle exocytosis Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. go.json http://purl.obolibrary.org/obo/GO_0016079 goslim_synapse GO:0031694 biolink:MolecularActivity alpha-2A adrenergic receptor binding Binding to an alpha-2A adrenergic receptor. go.json alpha-2A adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031694 GO:0031695 biolink:MolecularActivity alpha-2B adrenergic receptor binding Binding to an alpha-2B adrenergic receptor. go.json alpha-2B adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031695 GO:0031692 biolink:MolecularActivity alpha-1B adrenergic receptor binding Binding to an alpha-1B adrenergic receptor. go.json alpha-1B adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031692 GO:0016073 biolink:BiologicalProcess snRNA metabolic process The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. go.json snRNA metabolism http://purl.obolibrary.org/obo/GO_0016073 goslim_drosophila|goslim_generic|goslim_pombe GO:0016074 biolink:BiologicalProcess sno(s)RNA metabolic process The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. go.json box C/D sRNA metabolic process|snoRNA metabolism http://purl.obolibrary.org/obo/GO_0016074 goslim_drosophila|goslim_pombe GO:0031693 biolink:MolecularActivity alpha-1D adrenergic receptor binding Binding to an alpha-1D adrenergic receptor. go.json alpha-1D adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031693 GO:0016075 biolink:BiologicalProcess rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. go.json rRNA breakdown|rRNA catabolism|rRNA degradation http://purl.obolibrary.org/obo/GO_0016075 GO:0031690 biolink:MolecularActivity adrenergic receptor binding Binding to an adrenergic receptor. go.json adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031690 GO:0016076 biolink:BiologicalProcess snRNA catabolic process The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. go.json snRNA breakdown|snRNA catabolism|snRNA degradation http://purl.obolibrary.org/obo/GO_0016076 GO:0031691 biolink:MolecularActivity alpha-1A adrenergic receptor binding Binding to an alpha-1A adrenergic receptor. go.json alpha-1A adrenergic receptor ligand http://purl.obolibrary.org/obo/GO_0031691 GO:0016050 biolink:BiologicalProcess vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. go.json vesicle organisation|vesicle organization and biogenesis http://purl.obolibrary.org/obo/GO_0016050 goslim_pir|goslim_yeast GO:0031689 biolink:MolecularActivity A3 adenosine receptor binding Binding to an A3 adenosine receptor. go.json A3 adenosine receptor ligand http://purl.obolibrary.org/obo/GO_0031689 GO:0031687 biolink:MolecularActivity A2A adenosine receptor binding Binding to an A2A adenosine receptor. go.json A2A adenosine receptor ligand http://purl.obolibrary.org/obo/GO_0031687 GO:0031688 biolink:MolecularActivity A2B adenosine receptor binding Binding to an A2B adenosine receptor. go.json A2B adenosine receptor ligand http://purl.obolibrary.org/obo/GO_0031688 GO:0016048 biolink:BiologicalProcess detection of temperature stimulus The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. go.json detection of temperature|detection of thermal stimulus|perception of temperature http://purl.obolibrary.org/obo/GO_0016048 GO:0016049 biolink:BiologicalProcess cell growth The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. go.json cell expansion|cellular growth|growth of cell|metabolic process resulting in cell growth|metabolism resulting in cell growth|non-developmental cell growth|non-developmental growth of a unicellular organism http://purl.obolibrary.org/obo/GO_0016049 gocheck_do_not_annotate|goslim_drosophila|goslim_pir|goslim_plant GO:0031685 biolink:MolecularActivity adenosine receptor binding Binding to an adenosine receptor. go.json adenosine receptor ligand http://purl.obolibrary.org/obo/GO_0031685 GO:0016044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016044 GO:0031686 biolink:MolecularActivity A1 adenosine receptor binding Binding to an A1 adenosine receptor. go.json A1 adenosine receptor ligand http://purl.obolibrary.org/obo/GO_0031686 GO:0016045 biolink:BiologicalProcess detection of bacterium The series of events in which a stimulus from a bacterium is received and converted into a molecular signal. go.json detection of bacteria|perception of bacteria|perception of bacterium http://purl.obolibrary.org/obo/GO_0016045 GO:0016046 biolink:BiologicalProcess detection of fungus The series of events in which a stimulus from a fungus is received and converted into a molecular signal. go.json detection of fungi|detection of parasitic fungi|detection of parasitic fungus|perception of fungi|perception of fungus|perception of parasitic fungi|perception of parasitic fungus http://purl.obolibrary.org/obo/GO_0016046 GO:0031683 biolink:MolecularActivity G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits. go.json http://purl.obolibrary.org/obo/GO_0031683 GO:0016047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016047 GO:0031684 biolink:BiologicalProcess obsolete heterotrimeric G-protein complex cycle OBSOLETE. The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits. go.json True http://purl.obolibrary.org/obo/GO_0031684 GO:0016040 biolink:MolecularActivity glutamate synthase (NADH) activity Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH. EC:1.4.1.14|KEGG_REACTION:R00093|MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN|RHEA:13753 go.json GOGAT activity|L-glutamate synthase (NADH)|L-glutamate synthase activity|L-glutamate synthetase activity|L-glutamate:NAD+ oxidoreductase (transaminating)|NADH-dependent glutamate synthase activity|NADH-glutamate synthase activity|NADH: GOGAT|glutamate (reduced nicotinamide adenine dinucleotide) synthase http://purl.obolibrary.org/obo/GO_0016040 GO:0031681 biolink:MolecularActivity G-protein beta-subunit binding Binding to a G-protein beta subunit. go.json G-beta protein subunit binding http://purl.obolibrary.org/obo/GO_0031681 GO:0016041 biolink:MolecularActivity glutamate synthase (ferredoxin) activity Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. EC:1.4.7.1|MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN|MetaCyc:PWY-4341|RHEA:12128 go.json L-glutamate:ferredoxin oxidoreductase (transaminating)|ferredoxin-dependent glutamate synthase activity|ferredoxin-glutamate synthase activity|glutamate synthase (ferredoxin-dependent) http://purl.obolibrary.org/obo/GO_0016041 GO:0031682 biolink:MolecularActivity G-protein gamma-subunit binding Binding to a G-protein gamma subunit. go.json G-gamma protein subunit binding http://purl.obolibrary.org/obo/GO_0031682 GO:0016042 biolink:BiologicalProcess lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Wikipedia:Lipid_catabolism go.json lipid breakdown|lipid catabolism|lipid degradation|lipolysis|multicellular organism lipid catabolic process|multicellular organismal lipid catabolic process http://purl.obolibrary.org/obo/GO_0016042 GO:0016043 biolink:BiologicalProcess cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. go.json cell organisation|cell organization and biogenesis|cellular component organisation at cellular level|cellular component organisation in other organism|cellular component organization at cellular level|cellular component organization in other organism http://purl.obolibrary.org/obo/GO_0016043 goslim_agr|goslim_mouse|goslim_pir|goslim_plant GO:0031680 biolink:CellularComponent G-protein beta/gamma-subunit complex The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange. go.json G-beta/G-gamma complex|heterotrimeric G-protein GTPase, beta-subunit http://purl.obolibrary.org/obo/GO_0031680 GO:0016060 biolink:BiologicalProcess metarhodopsin inactivation The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it. go.json http://purl.obolibrary.org/obo/GO_0016060 GO:0016061 biolink:BiologicalProcess regulation of light-activated channel activity Any process that modulates the frequency, rate or extent of light-activated channel activity. go.json http://purl.obolibrary.org/obo/GO_0016061 gocheck_do_not_annotate GO:0031678 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031678 GO:0031679 biolink:MolecularActivity NADH dehydrogenase (plastoquinone) activity Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol. go.json NADH:plastoquinone reductase activity http://purl.obolibrary.org/obo/GO_0031679 GO:0031676 biolink:CellularComponent plasma membrane-derived thylakoid membrane The pigmented membrane of a plasma membrane-derived thylakoid. go.json plasma membrane thylakoid membrane http://purl.obolibrary.org/obo/GO_0031676 GO:0031677 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031677 GO:0065010 biolink:CellularComponent extracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. go.json extracellular membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0065010 GO:0016059 biolink:BiologicalProcess deactivation of rhodopsin mediated signaling The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon). go.json deactivation of rhodopsin mediated signalling|rod response recovery http://purl.obolibrary.org/obo/GO_0016059 GO:0016055 biolink:BiologicalProcess Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. go.json Wg signaling pathway|Wg signalling pathway|Wingless signaling pathway|Wingless signalling pathway|Wnt receptor signaling pathway|Wnt receptor signalling pathway|Wnt-activated signaling pathway|frizzled signaling pathway|frizzled signalling pathway http://purl.obolibrary.org/obo/GO_0016055 GO:0031674 biolink:CellularComponent I band A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. Wikipedia:Sarcomere#bands go.json I disc|J disc|isotropic disc http://purl.obolibrary.org/obo/GO_0031674 GO:0016056 biolink:BiologicalProcess rhodopsin mediated signaling pathway A G protein-coupled receptor signaling pathway initiated by the excitation of rhodopsin by a photon, and ending with the regulation of a downstream cellular process. go.json rhodopsin mediated phototransduction|rhodopsin mediated signalling pathway|rhodopsin signaling http://purl.obolibrary.org/obo/GO_0016056 GO:0031675 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031675 GO:0016057 biolink:BiologicalProcess regulation of membrane potential in photoreceptor cell Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. go.json changes in polarization state of photoreceptor cell membrane http://purl.obolibrary.org/obo/GO_0016057 GO:0031672 biolink:CellularComponent A band The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. Wikipedia:Sarcomere#bands go.json A disc|Q disc|anisotropic disc|transverse disc http://purl.obolibrary.org/obo/GO_0031672 GO:0016058 biolink:BiologicalProcess maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon. go.json maintenance of rhodopsin mediated signaling|maintenance of rhodopsin mediated signalling http://purl.obolibrary.org/obo/GO_0016058 GO:0031673 biolink:CellularComponent H zone A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments. Wikipedia:Sarcomere#bands go.json H band|H disc http://purl.obolibrary.org/obo/GO_0031673 GO:0016051 biolink:BiologicalProcess carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. go.json anabolic carbohydrate metabolic process|anabolic carbohydrate metabolism|carbohydrate anabolism|carbohydrate biosynthesis|carbohydrate formation|carbohydrate synthesis http://purl.obolibrary.org/obo/GO_0016051 GO:0031670 biolink:BiologicalProcess cellular response to nutrient Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. go.json http://purl.obolibrary.org/obo/GO_0031670 GO:0031671 biolink:BiologicalProcess primary cell septum biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division. go.json http://purl.obolibrary.org/obo/GO_0031671 GO:0016052 biolink:BiologicalProcess carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. go.json carbohydrate breakdown|carbohydrate catabolism|carbohydrate degradation|catabolic carbohydrate metabolic process|catabolic carbohydrate metabolism|multicellular organismal carbohydrate catabolic process|single-organism carbohydrate catabolic process http://purl.obolibrary.org/obo/GO_0016052 GO:0016053 biolink:BiologicalProcess organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. go.json organic acid anabolism|organic acid biosynthesis|organic acid formation|organic acid synthesis http://purl.obolibrary.org/obo/GO_0016053 GO:0016054 biolink:BiologicalProcess organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. go.json organic acid breakdown|organic acid catabolism|organic acid degradation http://purl.obolibrary.org/obo/GO_0016054 GO:0031669 biolink:BiologicalProcess cellular response to nutrient levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. go.json http://purl.obolibrary.org/obo/GO_0031669 GO:0031667 biolink:BiologicalProcess response to nutrient levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. go.json http://purl.obolibrary.org/obo/GO_0031667 GO:0031668 biolink:BiologicalProcess cellular response to extracellular stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. go.json http://purl.obolibrary.org/obo/GO_0031668 GO:0031665 biolink:BiologicalProcess negative regulation of lipopolysaccharide-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. go.json down regulation of lipopolysaccharide-mediated signaling pathway|down-regulation of lipopolysaccharide-mediated signaling pathway|downregulation of lipopolysaccharide-mediated signaling pathway|inhibition of lipopolysaccharide-mediated signaling pathway|negative regulation of LPS-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0031665 GO:0031666 biolink:BiologicalProcess positive regulation of lipopolysaccharide-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. go.json activation of lipopolysaccharide-mediated signaling pathway|positive regulation of LPS-mediated signaling pathway|positive regulation of lipopolysaccharide-mediated signalling pathway|stimulation of lipopolysaccharide-mediated signaling pathway|up regulation of lipopolysaccharide-mediated signaling pathway|up-regulation of lipopolysaccharide-mediated signaling pathway|upregulation of lipopolysaccharide-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0031666 GO:0090008 biolink:BiologicalProcess hypoblast development The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast. go.json http://purl.obolibrary.org/obo/GO_0090008 GO:0090009 biolink:BiologicalProcess primitive streak formation The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. go.json http://purl.obolibrary.org/obo/GO_0090009 GO:0090006 biolink:BiologicalProcess regulation of linear element assembly Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase. go.json http://purl.obolibrary.org/obo/GO_0090006 GO:0090007 biolink:BiologicalProcess obsolete regulation of mitotic anaphase OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other. go.json regulation of mitotic anaphase True http://purl.obolibrary.org/obo/GO_0090007 GO:0016026 biolink:MolecularActivity obsolete proteasome endopeptidase core OBSOLETE. (Was not defined before being made obsolete). go.json proteasome endopeptidase core True http://purl.obolibrary.org/obo/GO_0016026 GO:0016027 biolink:CellularComponent inaD signaling complex A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD. go.json inaD signalling complex http://purl.obolibrary.org/obo/GO_0016027 GO:0016028 biolink:CellularComponent rhabdomere The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction. go.json http://purl.obolibrary.org/obo/GO_0016028 goslim_pir GO:0016029 biolink:CellularComponent subrhabdomeral cisterna A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase. go.json SMC|submicrovillar cisterna http://purl.obolibrary.org/obo/GO_0016029 GO:0031663 biolink:BiologicalProcess lipopolysaccharide-mediated signaling pathway The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. go.json LPS-mediated signaling pathway|lipopolysaccharide-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0031663 GO:0016022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016022 GO:0031664 biolink:BiologicalProcess regulation of lipopolysaccharide-mediated signaling pathway Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. go.json regulation of LPS-mediated signaling pathway|regulation of lipopolysaccharide-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0031664 GO:0090001 biolink:BiologicalProcess replication fork arrest at tRNA locus A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit. go.json http://purl.obolibrary.org/obo/GO_0090001 GO:0016023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016023 GO:0031661 biolink:BiologicalProcess obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle. go.json G2/M-specific down regulation of cyclin-dependent protein kinase activity|G2/M-specific down-regulation of cyclin-dependent protein kinase activity|G2/M-specific downregulation of cyclin-dependent protein kinase activity|G2/M-specific inhibition of cyclin-dependent protein kinase activity|G2/M-specific negative regulation of cyclin-dependent protein kinase activity|negative regulation of cyclin-dependent protein kinase activity during G2/M|negative regulation of cyclin-dependent protein kinase activity involved in G2/M True http://purl.obolibrary.org/obo/GO_0031661 GO:0016024 biolink:BiologicalProcess CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. go.json CDP-diacylglycerol anabolism|CDP-diacylglycerol biosynthesis|CDP-diacylglycerol formation|CDP-diacylglycerol synthesis http://purl.obolibrary.org/obo/GO_0016024 GO:0016025 biolink:MolecularActivity obsolete proteasome endopeptidase regulator OBSOLETE. (Was not defined before being made obsolete). go.json proteasome endopeptidase regulator True http://purl.obolibrary.org/obo/GO_0016025 GO:0031662 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031662 GO:0090004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090004 GO:0031660 biolink:BiologicalProcess obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle. go.json G2/M-specific regulation of cyclin-dependent protein kinase activity|regulation of cyclin-dependent protein kinase activity during G2/M|regulation of cyclin-dependent protein kinase activity involved in G2/M True http://purl.obolibrary.org/obo/GO_0031660 GO:0090005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090005 GO:0016020 biolink:CellularComponent membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. Wikipedia:Biological_membrane|Wikipedia:Transmembrane_protein go.json integral component of membrane|integral to membrane|membrane region|region of membrane|transmembrane|whole membrane http://purl.obolibrary.org/obo/GO_0016020 goslim_candida|goslim_chembl|goslim_flybase_ribbon|goslim_metagenomics|goslim_pir|goslim_plant|goslim_yeast GO:0090002 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090002 GO:0016021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016021 GO:0090003 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090003 GO:0031658 biolink:BiologicalProcess obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle. go.json G1/S-specific down regulation of cyclin-dependent protein kinase activity|G1/S-specific down-regulation of cyclin-dependent protein kinase activity|G1/S-specific downregulation of cyclin-dependent protein kinase activity|G1/S-specific inhibition of cyclin-dependent protein kinase activity|G1/S-specific negative regulation of cyclin-dependent protein kinase activity|negative regulation of cyclin-dependent protein kinase activity during G1/S|negative regulation of cyclin-dependent protein kinase activity involved in G1/S True http://purl.obolibrary.org/obo/GO_0031658 GO:0031659 biolink:BiologicalProcess obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle. go.json G1/S-specific activation of cyclin-dependent protein kinase activity|G1/S-specific positive regulation of cyclin-dependent protein kinase activity|G1/S-specific stimulation of cyclin-dependent protein kinase activity|G1/S-specific up regulation of cyclin-dependent protein kinase activity|G1/S-specific up-regulation of cyclin-dependent protein kinase activity|G1/S-specific upregulation of cyclin-dependent protein kinase activity|positive regulation of cyclin-dependent protein kinase activity during G1/S|positive regulation of cyclin-dependent protein kinase activity involved in G1/S True http://purl.obolibrary.org/obo/GO_0031659 GO:0031656 biolink:BiologicalProcess positive regulation of heat dissipation Any process that activates or increases the rate or extent of heat dissipation. go.json activation of heat dissipation|stimulation of heat dissipation|up regulation of heat dissipation|up-regulation of heat dissipation|upregulation of heat dissipation http://purl.obolibrary.org/obo/GO_0031656 GO:0031657 biolink:BiologicalProcess obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle OBSOLETE. Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle. go.json G1/S-specific regulation of cyclin-dependent protein kinase activity|regulation of cyclin-dependent protein kinase activity during G1/S|regulation of cyclin-dependent protein kinase activity involved in G1/S True http://purl.obolibrary.org/obo/GO_0031657 GO:0031654 biolink:BiologicalProcess regulation of heat dissipation Any process that modulates the rate or extent of heat dissipation. go.json http://purl.obolibrary.org/obo/GO_0031654 GO:0031655 biolink:BiologicalProcess negative regulation of heat dissipation Any process that stops, prevents, or reduces the rate or extent of heat dissipation. go.json down regulation of heat dissipation|down-regulation of heat dissipation|downregulation of heat dissipation|inhibition of heat dissipation http://purl.obolibrary.org/obo/GO_0031655 GO:0090019 biolink:BiologicalProcess obsolete regulation of transcription involved in anterior neural plate formation OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate. go.json True http://purl.obolibrary.org/obo/GO_0090019 GO:0090017 biolink:BiologicalProcess anterior neural plate formation The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate. go.json http://purl.obolibrary.org/obo/GO_0090017 GO:0090018 biolink:BiologicalProcess posterior neural plate formation The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate. go.json http://purl.obolibrary.org/obo/GO_0090018 GO:0016037 biolink:BiologicalProcess light absorption The reception of a photon by a cell. go.json absorption of light http://purl.obolibrary.org/obo/GO_0016037 GO:0016038 biolink:BiologicalProcess absorption of visible light The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm. go.json http://purl.obolibrary.org/obo/GO_0016038 GO:0016039 biolink:BiologicalProcess absorption of UV light The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm. go.json http://purl.obolibrary.org/obo/GO_0016039 GO:0090011 biolink:BiologicalProcess Wnt signaling pathway involved in primitive streak formation The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak. go.json Wnt receptor signaling pathway involved in primitive streak formation|Wnt receptor signalling pathway involved in primitive streak formation|Wnt-activated signaling pathway involved in primitive streak formation http://purl.obolibrary.org/obo/GO_0090011 GO:0031652 biolink:BiologicalProcess positive regulation of heat generation Any process that activates or increases the rate or extent of heat generation. go.json activation of heat generation|stimulation of heat generation|up regulation of heat generation|up-regulation of heat generation|upregulation of heat generation http://purl.obolibrary.org/obo/GO_0031652 GO:0016033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016033 GO:0090012 biolink:BiologicalProcess obsolete negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak. go.json negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation True http://purl.obolibrary.org/obo/GO_0090012 GO:0016034 biolink:MolecularActivity maleylacetoacetate isomerase activity Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. EC:5.2.1.2|MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN|RHEA:14817|Reactome:R-HSA-71173|UM-BBD_reactionID:r0106 go.json 4-maleylacetoacetate cis-trans-isomerase activity|maleylacetoacetic isomerase activity|maleylacetone cis-trans-isomerase activity|maleylacetone isomerase activity http://purl.obolibrary.org/obo/GO_0016034 GO:0031653 biolink:BiologicalProcess heat dissipation Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature. go.json http://purl.obolibrary.org/obo/GO_0031653 GO:0031650 biolink:BiologicalProcess regulation of heat generation Any process that modulates the rate or extent of heat generation. go.json http://purl.obolibrary.org/obo/GO_0031650 GO:0016035 biolink:CellularComponent zeta DNA polymerase complex A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. go.json http://purl.obolibrary.org/obo/GO_0016035 GO:0031651 biolink:BiologicalProcess negative regulation of heat generation Any process that stops, prevents, or reduces the rate or extent of heat generation. go.json down regulation of heat generation|down-regulation of heat generation|downregulation of heat generation|inhibition of heat generation http://purl.obolibrary.org/obo/GO_0031651 GO:0090010 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in primitive streak formation OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak. go.json TGFbeta signaling pathway involved in primitive streak formation|transforming growth factor beta receptor signalling pathway involved in primitive streak formation True http://purl.obolibrary.org/obo/GO_0090010 GO:0016036 biolink:BiologicalProcess cellular response to phosphate starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. go.json http://purl.obolibrary.org/obo/GO_0016036 GO:0090015 biolink:BiologicalProcess positive regulation of leaflet formation by auxin mediated signaling pathway Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin. go.json positive regulation of leaflet formation by auxin mediated signalling pathway http://purl.obolibrary.org/obo/GO_0090015 GO:0090016 biolink:BiologicalProcess regulation of leaflet formation Any process that modulates the frequency, rate or extent of leaflet formation. go.json http://purl.obolibrary.org/obo/GO_0090016 GO:0016030 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016030 GO:0090013 biolink:BiologicalProcess obsolete regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation OBSOLETE. Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak. go.json regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation True http://purl.obolibrary.org/obo/GO_0090013 GO:0016031 biolink:BiologicalProcess tRNA import into mitochondrion The process in which a tRNA is transported from the cytosol into the mitochondrial matrix. go.json cytoplasmic tRNA import into mitochondria|cytoplasmic tRNA import into mitochondrion|cytoplasmic tRNA transport into mitochondrion|cytoplasmic tRNA, mitochondrial import|mitochondrial import of cytoplasmic tRNA|nuclear-encoded tRNA import into mitochondrion http://purl.obolibrary.org/obo/GO_0016031 GO:0016032 biolink:BiologicalProcess viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. Wikipedia:Viral_life_cycle go.json viral infection|virulence|virus process http://purl.obolibrary.org/obo/GO_0016032 goslim_metagenomics|goslim_pir GO:0090014 biolink:BiologicalProcess leaflet formation The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf. go.json http://purl.obolibrary.org/obo/GO_0090014 GO:0031649 biolink:BiologicalProcess heat generation Any homeostatic process in which an organism produces heat, thereby raising its internal temperature. go.json http://purl.obolibrary.org/obo/GO_0031649 GO:0031647 biolink:BiologicalProcess regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. go.json http://purl.obolibrary.org/obo/GO_0031647 goslim_pir GO:0031648 biolink:BiologicalProcess protein destabilization Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. go.json negative regulation of protein stability|protein destabilisation http://purl.obolibrary.org/obo/GO_0031648 GO:0031645 biolink:BiologicalProcess negative regulation of nervous system process Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. go.json down regulation of neurological process|down-regulation of neurological process|downregulation of neurological process|inhibition of neurological process|negative regulation of neurological process|negative regulation of neurological system process|negative regulation of neurophysiological process http://purl.obolibrary.org/obo/GO_0031645 GO:0006689 biolink:BiologicalProcess ganglioside catabolic process The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. go.json ganglioside breakdown|ganglioside catabolism|ganglioside degradation http://purl.obolibrary.org/obo/GO_0006689 GO:0031646 biolink:BiologicalProcess positive regulation of nervous system process Any process that activates or increases the frequency, rate or extent of a neurophysiological process. go.json activation of neurological process|positive regulation of neurological process|positive regulation of neurological system process|positive regulation of neurophysiological process|stimulation of neurological process|up regulation of neurological process|up-regulation of neurological process|upregulation of neurological process http://purl.obolibrary.org/obo/GO_0031646 GO:0031643 biolink:BiologicalProcess positive regulation of myelination Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. go.json activation of myelination|stimulation of myelination|up regulation of myelination|up-regulation of myelination|upregulation of myelination http://purl.obolibrary.org/obo/GO_0031643 GO:0006687 biolink:BiologicalProcess glycosphingolipid metabolic process The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. go.json glycosphingolipid metabolism http://purl.obolibrary.org/obo/GO_0006687 GO:0006688 biolink:BiologicalProcess glycosphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. go.json glycosphingolipid anabolism|glycosphingolipid biosynthesis|glycosphingolipid formation|glycosphingolipid synthesis http://purl.obolibrary.org/obo/GO_0006688 GO:0031644 biolink:BiologicalProcess regulation of nervous system process Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. go.json regulation of neurological process|regulation of neurological system process|regulation of neurophysiological process http://purl.obolibrary.org/obo/GO_0031644 GO:0006685 biolink:BiologicalProcess sphingomyelin catabolic process The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. go.json sphingomyelin breakdown|sphingomyelin catabolism|sphingomyelin degradation http://purl.obolibrary.org/obo/GO_0006685 GO:0006686 biolink:BiologicalProcess sphingomyelin biosynthetic process The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. go.json sphingomyelin anabolism|sphingomyelin biosynthesis|sphingomyelin formation|sphingomyelin synthesis http://purl.obolibrary.org/obo/GO_0006686 GO:0006683 biolink:BiologicalProcess galactosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. go.json galactosylceramide breakdown|galactosylceramide catabolism|galactosylceramide degradation http://purl.obolibrary.org/obo/GO_0006683 GO:0006684 biolink:BiologicalProcess sphingomyelin metabolic process The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. go.json sphingomyelin metabolism http://purl.obolibrary.org/obo/GO_0006684 GO:0006681 biolink:BiologicalProcess galactosylceramide metabolic process The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. go.json galactosylceramide metabolism http://purl.obolibrary.org/obo/GO_0006681 GO:0006682 biolink:BiologicalProcess galactosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. go.json galactosylceramide anabolism|galactosylceramide biosynthesis|galactosylceramide formation|galactosylceramide synthesis http://purl.obolibrary.org/obo/GO_0006682 GO:0006680 biolink:BiologicalProcess glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. go.json glucosylceramide breakdown|glucosylceramide catabolism|glucosylceramide degradation http://purl.obolibrary.org/obo/GO_0006680 GO:0016008 biolink:CellularComponent major mitochondrial derivative The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative. go.json http://purl.obolibrary.org/obo/GO_0016008 GO:0016009 biolink:CellularComponent minor mitochondrial derivative The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation. go.json http://purl.obolibrary.org/obo/GO_0016009 GO:0016004 biolink:MolecularActivity phospholipase activator activity Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. go.json http://purl.obolibrary.org/obo/GO_0016004 GO:0016005 biolink:MolecularActivity phospholipase A2 activator activity Binds to and increases the activity of the enzyme phospholipase A2. go.json http://purl.obolibrary.org/obo/GO_0016005 GO:0016006 biolink:CellularComponent Nebenkern A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme. go.json http://purl.obolibrary.org/obo/GO_0016006 GO:0016007 biolink:CellularComponent mitochondrial derivative The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation. go.json http://purl.obolibrary.org/obo/GO_0016007 GO:0031641 biolink:BiologicalProcess regulation of myelination Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. go.json http://purl.obolibrary.org/obo/GO_0031641 GO:0016000 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016000 GO:0016001 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016001 GO:0031642 biolink:BiologicalProcess negative regulation of myelination Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. go.json down regulation of myelination|down-regulation of myelination|downregulation of myelination|inhibition of myelination http://purl.obolibrary.org/obo/GO_0031642 GO:0016002 biolink:MolecularActivity sulfite reductase activity Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor. go.json assimilatory sulfite reductase activity|assimilatory-type sulfite reductase activity|hydrogen-sulfide:(acceptor) oxidoreductase activity|hydrogen-sulfide:acceptor oxidoreductase activity|sulphite reductase activity http://purl.obolibrary.org/obo/GO_0016002 GO:0031640 biolink:BiologicalProcess killing of cells of another organism Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. go.json killing of cells of other organism http://purl.obolibrary.org/obo/GO_0031640 goslim_pir GO:0016003 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016003 GO:0031638 biolink:BiologicalProcess zymogen activation The proteolytic processing of an inactive enzyme to an active form. go.json zymogen activation by proteolytic cleavage http://purl.obolibrary.org/obo/GO_0031638 goslim_chembl GO:0031639 biolink:BiologicalProcess plasminogen activation The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. go.json cleavage of plasminogen to plasmin http://purl.obolibrary.org/obo/GO_0031639 goslim_chembl GO:0031636 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031636 GO:0031637 biolink:BiologicalProcess regulation of neuronal synaptic plasticity in response to neurotrophin The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. go.json neurotrophin-induced neuronal synaptic plasticity http://purl.obolibrary.org/obo/GO_0031637 GO:0031634 biolink:MolecularActivity replication fork barrier binding Binding to replication fork barriers, sites that inhibit the progress of replication forks. go.json http://purl.obolibrary.org/obo/GO_0031634 GO:0031635 biolink:BiologicalProcess adenylate cyclase-inhibiting opioid receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process. go.json inhibition of adenylate cyclase activity by opioid receptor signaling pathway|inhibition of adenylate cyclase activity by opioid receptor signalling pathway|opioid receptor, adenylate cyclase inhibiting pathway http://purl.obolibrary.org/obo/GO_0031635 GO:0031632 biolink:BiologicalProcess positive regulation of synaptic vesicle fusion to presynaptic active zone membrane Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. go.json activation of synaptic vesicle fusion to presynaptic membrane|negative regulation of synaptic vesicle fusion to presynaptic membrane|positive regulation of synaptic vesicle fusion to pre-synaptic membrane|stimulation of synaptic vesicle fusion to presynaptic membrane|up regulation of synaptic vesicle fusion to presynaptic active zone membrane|up regulation of synaptic vesicle fusion to presynaptic membrane|up-regulation of synaptic vesicle fusion to presynaptic active zone membrane|up-regulation of synaptic vesicle fusion to presynaptic membrane|upregulation of synaptic vesicle fusion to presynaptic membrane http://purl.obolibrary.org/obo/GO_0031632 GO:0006698 biolink:BiologicalProcess obsolete ecdysone modification OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties. go.json ecdysone modification True http://purl.obolibrary.org/obo/GO_0006698 GO:0031633 biolink:CellularComponent xanthophore A chromatophore containing yellow pigment. go.json http://purl.obolibrary.org/obo/GO_0031633 GO:0006699 biolink:BiologicalProcess bile acid biosynthetic process The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. go.json bile acid anabolism|bile acid biosynthesis|bile acid formation|bile acid synthesis http://purl.obolibrary.org/obo/GO_0006699 GO:0006696 biolink:BiologicalProcess ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. go.json ergosterol anabolism|ergosterol biosynthesis|ergosterol formation|ergosterol synthesis http://purl.obolibrary.org/obo/GO_0006696 GO:0006697 biolink:BiologicalProcess ecdysone biosynthetic process The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. go.json ecdysone anabolism|ecdysone biosynthesis|ecdysone formation|ecdysone synthesis http://purl.obolibrary.org/obo/GO_0006697 GO:0006694 biolink:BiologicalProcess steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. Wikipedia:Steroid_metabolisms#Steroid_biosynthesis go.json steroid anabolism|steroid biosynthesis|steroid formation|steroid synthesis|steroidogenesis http://purl.obolibrary.org/obo/GO_0006694 GO:0006695 biolink:BiologicalProcess cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json cholesterol anabolism|cholesterol biosynthesis|cholesterol formation|cholesterol synthesis http://purl.obolibrary.org/obo/GO_0006695 GO:0006692 biolink:BiologicalProcess prostanoid metabolic process The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. go.json prostanoid metabolism http://purl.obolibrary.org/obo/GO_0006692 GO:0006693 biolink:BiologicalProcess prostaglandin metabolic process The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. go.json prostaglandin metabolism http://purl.obolibrary.org/obo/GO_0006693 GO:0006690 biolink:BiologicalProcess icosanoid metabolic process The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. go.json eicosanoid metabolic process|eicosanoid metabolism|icosanoid metabolism http://purl.obolibrary.org/obo/GO_0006690 GO:0006691 biolink:BiologicalProcess leukotriene metabolic process The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. go.json leukotriene metabolism http://purl.obolibrary.org/obo/GO_0006691 GO:0016019 biolink:MolecularActivity peptidoglycan immune receptor activity Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response. go.json peptidoglycan receptor activity|peptidoglycan recognition activity http://purl.obolibrary.org/obo/GO_0016019 GO:0016015 biolink:MolecularActivity morphogen activity Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. go.json http://purl.obolibrary.org/obo/GO_0016015 GO:0016016 biolink:MolecularActivity obsolete short-wave-sensitive opsin OBSOLETE. An opsin with maximal absorption between 400 and 500 nm. go.json short-wave-sensitive opsin True http://purl.obolibrary.org/obo/GO_0016016 GO:0016017 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016017 GO:0016018 biolink:MolecularActivity cyclosporin A binding Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. go.json cyclophilin http://purl.obolibrary.org/obo/GO_0016018 GO:0031630 biolink:BiologicalProcess regulation of synaptic vesicle fusion to presynaptic active zone membrane Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. go.json regulation of synaptic vesicle fusion to pre-synaptic membrane|regulation of synaptic vesicle fusion to presynaptic membrane http://purl.obolibrary.org/obo/GO_0031630 goslim_synapse GO:0016011 biolink:CellularComponent dystroglycan complex A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin. go.json http://purl.obolibrary.org/obo/GO_0016011 GO:0016012 biolink:CellularComponent sarcoglycan complex A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex. go.json sarcoglycan-sarcospan complex http://purl.obolibrary.org/obo/GO_0016012 GO:0031631 biolink:BiologicalProcess negative regulation of synaptic vesicle fusion to presynaptic active zone membrane Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. go.json down regulation of synaptic vesicle fusion to presynaptic active zone membrane|down regulation of synaptic vesicle fusion to presynaptic membrane|down-regulation of synaptic vesicle fusion to presynaptic active zone membrane|down-regulation of synaptic vesicle fusion to presynaptic membrane|downregulation of synaptic vesicle fusion to presynaptic active zone membrane|downregulation of synaptic vesicle fusion to presynaptic membrane|inhibition of synaptic vesicle fusion to presynaptic membrane|negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane|negative regulation of synaptic vesicle fusion to pre-synaptic membrane|negative regulation of synaptic vesicle fusion to presynaptic membrane http://purl.obolibrary.org/obo/GO_0031631 GO:0016013 biolink:CellularComponent syntrophin complex A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase. go.json nitric oxide synthase-dystrophin complex, skeletal muscle http://purl.obolibrary.org/obo/GO_0016013 GO:0016014 biolink:CellularComponent dystrobrevin complex A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex. go.json http://purl.obolibrary.org/obo/GO_0016014 GO:0016010 biolink:CellularComponent dystrophin-associated glycoprotein complex A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase. go.json DGC|dystrophin glycoprotein complex http://purl.obolibrary.org/obo/GO_0016010 goslim_pir GO:0016091 biolink:BiologicalProcess prenol biosynthetic process The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. go.json prenol anabolism|prenol biosynthesis|prenol formation|prenol synthesis http://purl.obolibrary.org/obo/GO_0016091 GO:0016092 biolink:BiologicalProcess prenol catabolic process The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. go.json prenol breakdown|prenol catabolism|prenol degradation http://purl.obolibrary.org/obo/GO_0016092 GO:0016093 biolink:BiologicalProcess polyprenol metabolic process The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. go.json polyprenol metabolism http://purl.obolibrary.org/obo/GO_0016093 GO:0016094 biolink:BiologicalProcess polyprenol biosynthetic process The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. go.json polyprenol anabolism|polyprenol biosynthesis|polyprenol formation|polyprenol synthesis http://purl.obolibrary.org/obo/GO_0016094 GO:0016090 biolink:BiologicalProcess prenol metabolic process The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. go.json prenol metabolism http://purl.obolibrary.org/obo/GO_0016090 GO:0016088 biolink:MolecularActivity obsolete insulin OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids. go.json insulin True http://purl.obolibrary.org/obo/GO_0016088 GO:0016089 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016089 GO:0016084 biolink:MolecularActivity myostimulatory hormone activity The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0016084 GO:0016085 biolink:MolecularActivity myoinhibitory hormone activity The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0016085 GO:0016086 biolink:MolecularActivity obsolete allatostatin OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone. go.json allatostatin True http://purl.obolibrary.org/obo/GO_0016086 GO:0016087 biolink:MolecularActivity ecdysiostatic hormone activity The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion. go.json http://purl.obolibrary.org/obo/GO_0016087 GO:0016099 biolink:BiologicalProcess monoterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton. MetaCyc:PWY-3041 go.json monoterpenoid anabolism|monoterpenoid biosynthesis|monoterpenoid formation|monoterpenoid synthesis http://purl.obolibrary.org/obo/GO_0016099 GO:0016095 biolink:BiologicalProcess polyprenol catabolic process The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. go.json polyprenol breakdown|polyprenol catabolism|polyprenol degradation http://purl.obolibrary.org/obo/GO_0016095 GO:0016096 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016096 GO:0016097 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016097 GO:0016098 biolink:BiologicalProcess monoterpenoid metabolic process The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. go.json monoterpenoid metabolism http://purl.obolibrary.org/obo/GO_0016098 GO:0031627 biolink:BiologicalProcess telomeric loop formation The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region. go.json T loop biosynthesis|T loop formation|t-loop biosynthesis|t-loop formation http://purl.obolibrary.org/obo/GO_0031627 GO:0031628 biolink:MolecularActivity opioid receptor binding Binding to an opioid receptor. go.json http://purl.obolibrary.org/obo/GO_0031628 GO:0006669 biolink:BiologicalProcess sphinganine-1-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. go.json dihydrosphingosine-1-phosphate biosynthesis|dihydrosphingosine-1-phosphate biosynthetic process|sphinganine-1-phosphate anabolism|sphinganine-1-phosphate biosynthesis|sphinganine-1-phosphate formation|sphinganine-1-phosphate synthesis http://purl.obolibrary.org/obo/GO_0006669 GO:0031625 biolink:MolecularActivity ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. go.json ubiquitin ligase binding http://purl.obolibrary.org/obo/GO_0031625 GO:0031626 biolink:MolecularActivity beta-endorphin binding Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin. go.json http://purl.obolibrary.org/obo/GO_0031626 GO:0006667 biolink:BiologicalProcess sphinganine metabolic process The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol. go.json dihydrosphingosine metabolic process|dihydrosphingosine metabolism|sphinganine metabolism http://purl.obolibrary.org/obo/GO_0006667 GO:0031623 biolink:BiologicalProcess receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0031623 GO:0006668 biolink:BiologicalProcess sphinganine-1-phosphate metabolic process The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. go.json dihydrosphingosine-1-phosphate metabolic process|dihydrosphingosine-1-phosphate metabolism|sphinganine-1-phosphate metabolism http://purl.obolibrary.org/obo/GO_0006668 GO:0031624 biolink:MolecularActivity ubiquitin conjugating enzyme binding Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. go.json http://purl.obolibrary.org/obo/GO_0031624 GO:0031621 biolink:BiologicalProcess negative regulation of fever generation Any process that stops, prevents, or reduces the rate or extent of fever generation. go.json down regulation of fever|down-regulation of fever|downregulation of fever|inhibition of fever|negative regulation of pyrexia http://purl.obolibrary.org/obo/GO_0031621 GO:0006665 biolink:BiologicalProcess sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). go.json sphingolipid metabolism http://purl.obolibrary.org/obo/GO_0006665 GO:0006666 biolink:BiologicalProcess 3-keto-sphinganine metabolic process The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine. go.json 3-keto-dihydrosphingosine metabolic process|3-keto-dihydrosphingosine metabolism|3-keto-sphinganine metabolism http://purl.obolibrary.org/obo/GO_0006666 GO:0031622 biolink:BiologicalProcess positive regulation of fever generation Any process that activates or increases the frequency, rate, or extent of fever generation. go.json activation of fever|positive regulation of pyrexia|stimulation of fever|up regulation of fever|up-regulation of fever|upregulation of fever http://purl.obolibrary.org/obo/GO_0031622 GO:0006663 biolink:BiologicalProcess platelet activating factor biosynthetic process The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. go.json PAF biosynthesis|PAF biosynthetic process|platelet activating factor anabolism|platelet activating factor biosynthesis|platelet activating factor formation|platelet activating factor synthesis http://purl.obolibrary.org/obo/GO_0006663 GO:0006664 biolink:BiologicalProcess glycolipid metabolic process The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent. go.json glycolipid metabolism http://purl.obolibrary.org/obo/GO_0006664 GO:0006661 biolink:BiologicalProcess phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. go.json PtdIns biosynthesis|PtdIns biosynthetic process|phosphatidylinositol anabolism|phosphatidylinositol biosynthesis|phosphatidylinositol formation|phosphatidylinositol synthesis|phosphoinositide biosynthesis|phosphoinositide biosynthetic process http://purl.obolibrary.org/obo/GO_0006661 GO:0006662 biolink:BiologicalProcess glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. go.json glycerol ether metabolism http://purl.obolibrary.org/obo/GO_0006662 goslim_pir GO:0006660 biolink:BiologicalProcess phosphatidylserine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. go.json phosphatidylserine breakdown|phosphatidylserine catabolism|phosphatidylserine degradation http://purl.obolibrary.org/obo/GO_0006660 GO:0031629 biolink:BiologicalProcess synaptic vesicle fusion to presynaptic active zone membrane Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. go.json synaptic vesicle fusion|synaptic vesicle fusion to pre-synaptic membrane|synaptic vesicle fusion to presynaptic membrane http://purl.obolibrary.org/obo/GO_0031629 goslim_synapse GO:0031620 biolink:BiologicalProcess regulation of fever generation Any process that modulates the rate or extent of fever generation. go.json regulation of pyrexia http://purl.obolibrary.org/obo/GO_0031620 GO:0031616 biolink:CellularComponent spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized. go.json http://purl.obolibrary.org/obo/GO_0031616 GO:0031617 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031617 GO:0031614 biolink:CellularComponent obsolete ER proteasome regulatory particle, lid subcomplex OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031614 GO:0031615 biolink:CellularComponent cytosolic proteasome regulatory particle, lid subcomplex The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. go.json http://purl.obolibrary.org/obo/GO_0031615 GO:0031612 biolink:CellularComponent cytosolic proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell. go.json http://purl.obolibrary.org/obo/GO_0031612 GO:0006678 biolink:BiologicalProcess glucosylceramide metabolic process The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative. go.json glucosylceramide metabolism http://purl.obolibrary.org/obo/GO_0006678 GO:0031613 biolink:CellularComponent nuclear proteasome regulatory particle, lid subcomplex The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031613 GO:0006679 biolink:BiologicalProcess glucosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. go.json glucosylceramide anabolism|glucosylceramide biosynthesis|glucosylceramide formation|glucosylceramide synthesis http://purl.obolibrary.org/obo/GO_0006679 GO:0031610 biolink:CellularComponent nuclear proteasome regulatory particle, base subcomplex The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031610 GO:0006676 biolink:BiologicalProcess mannosyl diphosphorylinositol ceramide metabolic process The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative. go.json M(IP)2C metabolic process|M(IP)2C metabolism|mannosyl diphosphorylinositol ceramide metabolism http://purl.obolibrary.org/obo/GO_0006676 GO:0031611 biolink:CellularComponent obsolete ER proteasome regulatory particle, base subcomplex OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031611 GO:0006677 biolink:BiologicalProcess glycosylceramide metabolic process The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. go.json glycosylceramide metabolism http://purl.obolibrary.org/obo/GO_0006677 GO:0006674 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006674 GO:0006675 biolink:BiologicalProcess mannosyl-inositol phosphorylceramide metabolic process The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative. go.json MIPC metabolic process|MIPC metabolism|mannose inositol phosphoceramide metabolic process|mannose inositol phosphoceramide metabolism|mannose-inositol-P-ceramide (MIPC) metabolic process|mannose-inositol-P-ceramide (MIPC) metabolism|mannosyl-inositol-phosphorylceramide metabolism http://purl.obolibrary.org/obo/GO_0006675 GO:0006672 biolink:BiologicalProcess ceramide metabolic process The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. go.json ceramide metabolism http://purl.obolibrary.org/obo/GO_0006672 GO:0006673 biolink:BiologicalProcess inositol phosphoceramide metabolic process The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group. go.json inositol phosphorylceramide metabolic process|inositol phosphorylceramide metabolism|inositolphosphoceramide metabolism http://purl.obolibrary.org/obo/GO_0006673 GO:0006670 biolink:BiologicalProcess sphingosine metabolic process The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. go.json (4E)-sphing-4-enine metabolic process|(4E)-sphing-4-enine metabolism|sphing-4-enine metabolic process|sphing-4-enine metabolism|sphingosine metabolism http://purl.obolibrary.org/obo/GO_0006670 GO:0006671 biolink:BiologicalProcess phytosphingosine metabolic process The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids. go.json phytosphingosine metabolism http://purl.obolibrary.org/obo/GO_0006671 GO:0031618 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031618 GO:0031619 biolink:BiologicalProcess homologous chromosome orientation in meiotic metaphase I The cell cycle process in which the sister centromeres and kinetochores of one chromosome are fused and orientated so the chromosomes attach to microtubules that emanate from the same spindle pole. This process ensures that homologous l chromosomes are segregated at anaphase of meiosis I. go.json homologous chromosome orientation during meiosis|homologous chromosome orientation during meiosis I http://purl.obolibrary.org/obo/GO_0031619 GO:0006649 biolink:BiologicalProcess phospholipid transfer to membrane The transfer of a phospholipid from its site of synthesis to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0006649 GO:0031605 biolink:CellularComponent obsolete ER proteasome core complex, alpha-subunit complex OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031605 GO:0031606 biolink:CellularComponent cytosolic proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex. go.json http://purl.obolibrary.org/obo/GO_0031606 GO:0006647 biolink:BiologicalProcess phosphatidyl-N-monomethylethanolamine biosynthetic process The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. go.json PMME biosynthesis|PMME biosynthetic process|phosphatidyl-N-monomethylethanolamine anabolism|phosphatidyl-N-monomethylethanolamine biosynthesis|phosphatidyl-N-monomethylethanolamine formation|phosphatidyl-N-monomethylethanolamine synthesis http://purl.obolibrary.org/obo/GO_0006647 GO:0031603 biolink:CellularComponent cytosolic proteasome core complex The core complex of a proteasome located in the cytosol of a cell. go.json http://purl.obolibrary.org/obo/GO_0031603 GO:0006648 biolink:BiologicalProcess dihydrosphingosine-1-P pathway A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase. go.json http://purl.obolibrary.org/obo/GO_0006648 GO:0031604 biolink:CellularComponent nuclear proteasome core complex, alpha-subunit complex The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031604 GO:0031601 biolink:CellularComponent nuclear proteasome core complex The core complex of a proteasome located in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031601 GO:0006645 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006645 GO:0031602 biolink:CellularComponent obsolete ER proteasome core complex OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031602 GO:0006646 biolink:BiologicalProcess phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. go.json phosphatidylethanolamine anabolism|phosphatidylethanolamine biosynthesis|phosphatidylethanolamine formation|phosphatidylethanolamine synthesis http://purl.obolibrary.org/obo/GO_0006646 GO:0006643 biolink:BiologicalProcess membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. go.json membrane lipid metabolism http://purl.obolibrary.org/obo/GO_0006643 GO:0006644 biolink:BiologicalProcess phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. go.json phospholipid metabolism http://purl.obolibrary.org/obo/GO_0006644 GO:0031600 biolink:CellularComponent cytosolic proteasome regulatory particle A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. go.json http://purl.obolibrary.org/obo/GO_0031600 GO:0006641 biolink:BiologicalProcess triglyceride metabolic process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. go.json triacylglycerol metabolic process|triacylglycerol metabolism|triglyceride metabolism http://purl.obolibrary.org/obo/GO_0006641 GO:0006642 biolink:BiologicalProcess triglyceride mobilization The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism. go.json triacylglycerol mobilization http://purl.obolibrary.org/obo/GO_0006642 GO:0006640 biolink:BiologicalProcess monoacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. go.json monoacylglycerol anabolism|monoacylglycerol biosynthesis|monoacylglycerol formation|monoacylglycerol synthesis|monoglyceride biosynthesis|monoglyceride biosynthetic process http://purl.obolibrary.org/obo/GO_0006640 GO:0031609 biolink:CellularComponent cytosolic proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex. go.json http://purl.obolibrary.org/obo/GO_0031609 GO:0031607 biolink:CellularComponent nuclear proteasome core complex, beta-subunit complex The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0031607 GO:0031608 biolink:CellularComponent obsolete ER proteasome core complex, beta-subunit complex OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell. go.json True http://purl.obolibrary.org/obo/GO_0031608 GO:0006658 biolink:BiologicalProcess phosphatidylserine metabolic process The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. go.json phosphatidylserine metabolism http://purl.obolibrary.org/obo/GO_0006658 GO:0006659 biolink:BiologicalProcess phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. go.json phosphatidylserine anabolism|phosphatidylserine biosynthesis|phosphatidylserine formation|phosphatidylserine synthesis http://purl.obolibrary.org/obo/GO_0006659 GO:0006656 biolink:BiologicalProcess phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. go.json phosphatidylcholine anabolism|phosphatidylcholine biosynthesis|phosphatidylcholine formation|phosphatidylcholine synthesis http://purl.obolibrary.org/obo/GO_0006656 GO:0006657 biolink:BiologicalProcess CDP-choline pathway The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. MetaCyc:PWY3O-450 go.json Kennedy pathway|phosphatidylcholine biosynthesis from choline http://purl.obolibrary.org/obo/GO_0006657 GO:0006654 biolink:BiologicalProcess phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. go.json phosphatidic acid anabolism|phosphatidic acid biosynthesis|phosphatidic acid formation|phosphatidic acid synthesis http://purl.obolibrary.org/obo/GO_0006654 GO:0006655 biolink:BiologicalProcess phosphatidylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. go.json phosphatidylglycerol anabolism|phosphatidylglycerol biosynthesis|phosphatidylglycerol formation|phosphatidylglycerol synthesis http://purl.obolibrary.org/obo/GO_0006655 GO:0006652 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006652 GO:0006653 biolink:BiologicalProcess 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin. go.json 1,2-diacyl-sn-glycero-3-phosphocholine metabolism|lecithin metabolic process http://purl.obolibrary.org/obo/GO_0006653 GO:0006650 biolink:BiologicalProcess glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. go.json alpha-glycerophosphate pathway|glycerophospholipid metabolism|phosphoglyceride metabolic process|phosphoglyceride metabolism http://purl.obolibrary.org/obo/GO_0006650 GO:0006651 biolink:BiologicalProcess diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. go.json diacylglycerol anabolism|diacylglycerol biosynthesis|diacylglycerol formation|diacylglycerol synthesis|diglyceride biosynthesis http://purl.obolibrary.org/obo/GO_0006651 GO:0006627 biolink:BiologicalProcess protein processing involved in protein targeting to mitochondrion The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. go.json mitochondrial processing|mitochondrial protein processing during import http://purl.obolibrary.org/obo/GO_0006627 GO:0006628 biolink:BiologicalProcess obsolete mitochondrial translocation OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery. go.json mitochondrial translocation True http://purl.obolibrary.org/obo/GO_0006628 GO:0006625 biolink:BiologicalProcess protein targeting to peroxisome The process of directing proteins towards the peroxisome, usually using signals contained within the protein. go.json protein-peroxisome targeting http://purl.obolibrary.org/obo/GO_0006625 GO:0006626 biolink:BiologicalProcess protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. go.json mitochondrial protein import|mitochondrial translocation|protein import into mitochondrion|protein targeting to mitochondria|protein-mitochondrial targeting http://purl.obolibrary.org/obo/GO_0006626 GO:0006623 biolink:BiologicalProcess protein targeting to vacuole The process of directing proteins towards the vacuole, usually using signals contained within the protein. go.json protein vacuolar targeting|protein-vacuolar targeting|protein-vacuole targeting|vacuolar protein sorting http://purl.obolibrary.org/obo/GO_0006623 GO:0006624 biolink:BiologicalProcess vacuolar protein processing Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes. go.json vacuolar protein maturation|vacuolar proteolysis http://purl.obolibrary.org/obo/GO_0006624 GO:0006621 biolink:BiologicalProcess protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. go.json maintenance of protein location in ER lumen http://purl.obolibrary.org/obo/GO_0006621 GO:0006622 biolink:BiologicalProcess protein targeting to lysosome The process of directing proteins towards the lysosome using signals contained within the protein. go.json protein-lysosome targeting http://purl.obolibrary.org/obo/GO_0006622 GO:0006620 biolink:BiologicalProcess post-translational protein targeting to endoplasmic reticulum membrane The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. go.json SRP-independent endoplasmic reticulum protein-membrane targeting|posttranslational endoplasmic reticulum membrane targeting|posttranslational endoplasmic reticulum protein-membrane targeting|posttranslational protein endoplasmic reticulum membrane targeting|posttranslational protein targeting to ER membrane|posttranslational protein targeting to endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0006620 GO:0006629 biolink:BiologicalProcess lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. Wikipedia:Lipid_metabolism go.json lipid metabolism http://purl.obolibrary.org/obo/GO_0006629 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant|goslim_pombe|goslim_yeast|prokaryote_subset GO:0006638 biolink:BiologicalProcess neutral lipid metabolic process The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. go.json neutral lipid metabolism http://purl.obolibrary.org/obo/GO_0006638 GO:0006639 biolink:BiologicalProcess acylglycerol metabolic process The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. go.json acylglycerol metabolism|glyceride metabolic process|glyceride metabolism http://purl.obolibrary.org/obo/GO_0006639 GO:0006636 biolink:BiologicalProcess unsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. MetaCyc:PWY-762|MetaCyc:PWY-782 go.json fatty acid desaturation|polyunsaturated fatty acid biosynthesis|unsaturated fatty acid anabolism|unsaturated fatty acid biosynthesis|unsaturated fatty acid formation|unsaturated fatty acid synthesis http://purl.obolibrary.org/obo/GO_0006636 GO:0006637 biolink:BiologicalProcess acyl-CoA metabolic process The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. go.json acyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0006637 GO:0006634 biolink:BiologicalProcess hexadecanal biosynthetic process The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde. go.json hexadecanal anabolism|hexadecanal biosynthesis|hexadecanal formation|hexadecanal synthesis|palmitaldehyde biosynthesis|palmitaldehyde biosynthetic process http://purl.obolibrary.org/obo/GO_0006634 GO:0006635 biolink:BiologicalProcess fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). go.json http://purl.obolibrary.org/obo/GO_0006635 GO:0006632 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006632 GO:0006633 biolink:BiologicalProcess fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. MetaCyc:FASYN-INITIAL-PWY|MetaCyc:PWY-4381|MetaCyc:PWY-5156|Wikipedia:Fatty_acid_synthesis go.json fatty acid anabolism|fatty acid biosynthesis|fatty acid formation|fatty acid synthesis http://purl.obolibrary.org/obo/GO_0006633 GO:0006630 biolink:BiologicalProcess obsolete lipid binding OBSOLETE. (Was not defined before being made obsolete). go.json lipid binding True http://purl.obolibrary.org/obo/GO_0006630 GO:0006631 biolink:BiologicalProcess fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. Wikipedia:Fatty_acid_metabolism go.json fatty acid metabolism http://purl.obolibrary.org/obo/GO_0006631 GO:0006605 biolink:BiologicalProcess protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. Wikipedia:Protein_targeting go.json nascent polypeptide association|protein sorting along secretory pathway http://purl.obolibrary.org/obo/GO_0006605 goslim_chembl|goslim_pombe|goslim_yeast GO:0006606 biolink:BiologicalProcess protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. go.json establishment of protein localization to nucleus|protein import into cell nucleus|protein nucleus import|protein transport from cytoplasm to nucleus http://purl.obolibrary.org/obo/GO_0006606 GO:0006603 biolink:BiologicalProcess phosphocreatine metabolic process The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle. go.json phosphocreatine metabolism http://purl.obolibrary.org/obo/GO_0006603 GO:0006604 biolink:BiologicalProcess phosphoarginine metabolic process The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates. go.json phosphoarginine metabolism http://purl.obolibrary.org/obo/GO_0006604 GO:0006601 biolink:BiologicalProcess creatine biosynthetic process The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle. go.json creatine anabolism|creatine biosynthesis|creatine formation|creatine synthesis http://purl.obolibrary.org/obo/GO_0006601 GO:0006602 biolink:BiologicalProcess creatinine catabolic process The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. go.json creatinine breakdown|creatinine catabolism|creatinine degradation http://purl.obolibrary.org/obo/GO_0006602 GO:0006600 biolink:BiologicalProcess creatine metabolic process The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. go.json creatine metabolism http://purl.obolibrary.org/obo/GO_0006600 GO:0006609 biolink:BiologicalProcess obsolete mRNA-binding (hnRNP) protein import into nucleus OBSOLETE. The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane. go.json mRNA-binding (hnRNP) protein import into cell nucleus|mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus|mRNA-binding (hnRNP) protein-nucleus import True http://purl.obolibrary.org/obo/GO_0006609 GO:0006607 biolink:BiologicalProcess NLS-bearing protein import into nucleus The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope. go.json NLS-bearing substrate import into cell nucleus|NLS-bearing substrate import into nucleus|NLS-bearing substrate transport from cytoplasm to nucleus|NLS-bearing substrate-nucleus import http://purl.obolibrary.org/obo/GO_0006607 GO:0006608 biolink:BiologicalProcess obsolete snRNP protein import into nucleus OBSOLETE. The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane. go.json snRNP protein import into cell nucleus|snRNP protein transport from cytoplasm to nucleus|snRNP protein-nucleus import True http://purl.obolibrary.org/obo/GO_0006608 GO:0006616 biolink:BiologicalProcess SRP-dependent cotranslational protein targeting to membrane, translocation The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. go.json ER translocation|SRP-dependent cotranslational membrane targeting, translocation|SRP-dependent cotranslational protein-membrane targeting, translocation|translocation during SRP-dependent cotranslational protein targeting to membrane http://purl.obolibrary.org/obo/GO_0006616 GO:0006617 biolink:BiologicalProcess SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. go.json SRP-dependent cotranslational membrane targeting, signal sequence recognition|SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition|signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane http://purl.obolibrary.org/obo/GO_0006617 GO:0006614 biolink:BiologicalProcess SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. go.json ER translocation|SRP-dependent cotranslational membrane targeting|SRP-dependent cotranslational protein-membrane targeting http://purl.obolibrary.org/obo/GO_0006614 GO:0006615 biolink:BiologicalProcess SRP-dependent cotranslational protein targeting to membrane, docking The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting. go.json SRP-dependent cotranslational membrane targeting, docking|SRP-dependent cotranslational protein-membrane targeting, docking|protein docking during SRP-dependent cotranslational protein targeting to membrane http://purl.obolibrary.org/obo/GO_0006615 GO:0006612 biolink:BiologicalProcess protein targeting to membrane The process of directing proteins towards a membrane, usually using signals contained within the protein. go.json protein membrane targeting|protein-membrane targeting http://purl.obolibrary.org/obo/GO_0006612 GO:0006613 biolink:BiologicalProcess cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. go.json cotranslational membrane targeting|cotranslational protein membrane targeting|cotranslational protein-membrane targeting http://purl.obolibrary.org/obo/GO_0006613 GO:0006610 biolink:BiologicalProcess ribosomal protein import into nucleus The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus. go.json ribosomal protein import into cell nucleus|ribosomal protein transport from cytoplasm to nucleus|ribosomal protein-nucleus import http://purl.obolibrary.org/obo/GO_0006610 GO:0006611 biolink:BiologicalProcess protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm. go.json copper-induced protein export from nucleus|protein export from cell nucleus|protein export out of nucleus|protein transport from nucleus to cytoplasm|protein-nucleus export http://purl.obolibrary.org/obo/GO_0006611 GO:0006618 biolink:BiologicalProcess SRP-dependent cotranslational protein targeting to membrane, signal sequence processing The removal of the signal peptide from a nascent protein during cotranslational membrane targeting. go.json SRP-dependent cotranslational membrane targeting, signal sequence processing|SRP-dependent cotranslational protein-membrane targeting, signal sequence processing|signal sequence processing during SRP-dependent cotranslational protein targeting to membrane http://purl.obolibrary.org/obo/GO_0006618 GO:0006619 biolink:BiologicalProcess obsolete SRP-independent cotranslational protein-membrane targeting OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition. go.json ER translocation|SRP-independent cotranslational membrane targeting|SRP-independent cotranslational protein-membrane targeting True http://purl.obolibrary.org/obo/GO_0006619 GO:0016190 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016190 GO:0016191 biolink:BiologicalProcess synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. go.json synaptic vesicle coat depolymerization|synaptic vesicle coat protein depolymerization http://purl.obolibrary.org/obo/GO_0016191 goslim_synapse GO:0016192 biolink:BiologicalProcess vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. go.json nonselective vesicle transport|protein sorting along secretory pathway|vesicle trafficking|vesicle transport|vesicular transport http://purl.obolibrary.org/obo/GO_0016192 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe GO:0016193 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016193 GO:0016187 biolink:BiologicalProcess obsolete synaptic vesicle internalization OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis. go.json synaptic vesicle internalization True http://purl.obolibrary.org/obo/GO_0016187 GO:0016188 biolink:BiologicalProcess synaptic vesicle maturation Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle. go.json http://purl.obolibrary.org/obo/GO_0016188 GO:0016189 biolink:BiologicalProcess synaptic vesicle to endosome fusion Fusion of a synaptic vesicle with an endosome. go.json http://purl.obolibrary.org/obo/GO_0016189 goslim_synapse GO:0016183 biolink:BiologicalProcess synaptic vesicle coating The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles. go.json http://purl.obolibrary.org/obo/GO_0016183 goslim_synapse GO:0016184 biolink:BiologicalProcess obsolete synaptic vesicle retrieval OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane. go.json synaptic vesicle retrieval True http://purl.obolibrary.org/obo/GO_0016184 GO:0016185 biolink:BiologicalProcess synaptic vesicle budding from presynaptic endocytic zone membrane Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle. go.json synaptic vesicle budding from pre-synaptic membrane|synaptic vesicle budding involved in synaptic vesicle endocytosis http://purl.obolibrary.org/obo/GO_0016185 goslim_synapse GO:0016186 biolink:BiologicalProcess obsolete synaptic vesicle fission OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane. go.json synaptic vesicle fission True http://purl.obolibrary.org/obo/GO_0016186 GO:0016198 biolink:BiologicalProcess axon choice point recognition The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth. go.json http://purl.obolibrary.org/obo/GO_0016198 GO:0016199 biolink:BiologicalProcess axon midline choice point recognition The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline. go.json http://purl.obolibrary.org/obo/GO_0016199 GO:0016194 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016194 GO:0016195 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016195 GO:0016196 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016196 GO:0016197 biolink:BiologicalProcess endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. go.json endosome localisation|endosome localization|endosome transport http://purl.obolibrary.org/obo/GO_0016197 goslim_yeast GO:0016170 biolink:MolecularActivity interleukin-15 receptor binding Binding to an interleukin-15 receptor. go.json IL-15|interleukin-15 receptor ligand http://purl.obolibrary.org/obo/GO_0016170 GO:0016171 biolink:MolecularActivity obsolete cell surface antigen OBSOLETE. (Was not defined before being made obsolete). go.json cell surface antigen True http://purl.obolibrary.org/obo/GO_0016171 GO:0016169 biolink:MolecularActivity bacteriochlorophyll c binding Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria. go.json http://purl.obolibrary.org/obo/GO_0016169 GO:0016165 biolink:MolecularActivity linoleate 13S-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. EC:1.13.11.12|MetaCyc:LIPOXYGENASE-RXN|RHEA:22780 go.json carotene oxidase activity|fat oxidase activity|linoleate:oxygen 13-oxidoreductase activity|lionoleate:O2 oxidoreductase activity|lipoperoxidase activity|lipoxidase activity|lipoxydase activity|lipoxygenase activity http://purl.obolibrary.org/obo/GO_0016165 GO:0016166 biolink:MolecularActivity phytoene dehydrogenase activity Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene. go.json http://purl.obolibrary.org/obo/GO_0016166 GO:0016167 biolink:MolecularActivity glial cell-derived neurotrophic factor receptor activity Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json GDNF receptor activity|glial cell line-derived neurotrophic factor receptor activity http://purl.obolibrary.org/obo/GO_0016167 GO:0016168 biolink:MolecularActivity chlorophyll binding Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. go.json http://purl.obolibrary.org/obo/GO_0016168 GO:0016161 biolink:MolecularActivity beta-amylase activity Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. EC:3.2.1.2|MetaCyc:RXN-12279|MetaCyc:RXN-1827 go.json 4-alpha-D-glucan maltohydrolase activity|beta amylase activity|glycogenase activity|saccharogen amylase activity http://purl.obolibrary.org/obo/GO_0016161 GO:0016162 biolink:MolecularActivity cellulose 1,4-beta-cellobiosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. EC:3.2.1.91|MetaCyc:3.2.1.91-RXN go.json 1,4-beta-D-glucan cellobiohydrolase activity|1,4-beta-cellobiohydrolase activity|1,4-beta-glucan cellobiosidase activity|C1 cellulase activity|CBH 1|avicelase activity|beta-1,4-glucan cellobiohydrolase activity|beta-1,4-glucan cellobiosylhydrolase activity|cellobiohydrolase I|cellobiohydrolase activity|cellobiosidase activity|exo-1,4-beta-D-glucanase activity|exo-beta-1,4-glucan cellobiohydrolase activity|exo-cellobiohydrolase activity|exocellobiohydrolase activity|exoglucanase activity http://purl.obolibrary.org/obo/GO_0016162 GO:0016163 biolink:MolecularActivity nitrogenase activity Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. EC:1.18.6.1|MetaCyc:NITROGENASE-RXN|RHEA:21448|UM-BBD_enzymeID:e0395 go.json iron-iron nitrogenase activity|molybdenum-iron nitrogenase activity|reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity|vanadium-iron nitrogenase activity http://purl.obolibrary.org/obo/GO_0016163 GO:0016164 biolink:MolecularActivity obsolete Mo-molybdopterin oxidoreductase activity OBSOLETE. (Was not defined before being made obsolete). go.json Mo-molybdopterin oxidoreductase activity|molybdopterin oxidoreductase activity True http://purl.obolibrary.org/obo/GO_0016164 GO:0016180 biolink:BiologicalProcess snRNA processing Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres. go.json snRNA maturation|snRNA production http://purl.obolibrary.org/obo/GO_0016180 GO:0016181 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016181 GO:0016182 biolink:BiologicalProcess synaptic vesicle budding from endosome Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes. go.json endosome to synaptic vesicle budding|synaptic vesicle budding involved in synaptic vesicle exocytosis http://purl.obolibrary.org/obo/GO_0016182 goslim_synapse GO:0031799 biolink:MolecularActivity type 2 metabotropic glutamate receptor binding Binding to a type 2 metabotropic glutamate receptor. go.json type 2 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031799 GO:0031797 biolink:MolecularActivity type 2 metabotropic GABA receptor binding Binding to a type 2 metabotropic GABA receptor. go.json type 2 metabotropic GABA receptor ligand http://purl.obolibrary.org/obo/GO_0031797 GO:0031798 biolink:MolecularActivity type 1 metabotropic glutamate receptor binding Binding to a type 1 metabotropic glutamate receptor. go.json type 1 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031798 GO:0100001 biolink:BiologicalProcess regulation of skeletal muscle contraction by action potential Any action potential process that regulates skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0100001 GO:0100002 biolink:BiologicalProcess obsolete negative regulation of protein kinase activity by protein phosphorylation OBSOLETE. Any protein phosphorylation process that negatively regulates protein kinase activity. go.json True http://purl.obolibrary.org/obo/GO_0100002 GO:0100003 biolink:BiologicalProcess obsolete positive regulation of sodium ion transport by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sodium ion transport. go.json True http://purl.obolibrary.org/obo/GO_0100003 GO:0100004 biolink:BiologicalProcess obsolete positive regulation of peroxisome organization by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates peroxisome organization. go.json True http://purl.obolibrary.org/obo/GO_0100004 GO:0100005 biolink:BiologicalProcess obsolete positive regulation of ethanol catabolic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates ethanol catabolic process. go.json True http://purl.obolibrary.org/obo/GO_0100005 GO:0100006 biolink:BiologicalProcess obsolete positive regulation of sulfite transport by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sulfite transport. go.json True http://purl.obolibrary.org/obo/GO_0100006 GO:0100007 biolink:BiologicalProcess obsolete negative regulation of ceramide biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates ceramide biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100007 GO:0100008 biolink:BiologicalProcess regulation of fever generation by prostaglandin biosynthetic process Any prostaglandin biosynthetic process process that regulates fever generation. go.json http://purl.obolibrary.org/obo/GO_0100008 GO:0100009 biolink:BiologicalProcess regulation of fever generation by prostaglandin secretion Any prostaglandin secretion process that regulates fever generation. go.json http://purl.obolibrary.org/obo/GO_0100009 GO:0016176 biolink:MolecularActivity superoxide-generating NADPH oxidase activator activity Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase. go.json neutrophil cytosol factor 2 http://purl.obolibrary.org/obo/GO_0016176 GO:0031795 biolink:MolecularActivity G protein-coupled GABA receptor binding Binding to a G protein-coupled (metabotropic) GABA receptor. go.json G-protein coupled GABA receptor binding|GABAB receptor binding|metabotropic GABA receptor binding|metabotropic GABA receptor ligand http://purl.obolibrary.org/obo/GO_0031795 GO:0016177 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016177 GO:0031796 biolink:MolecularActivity type 1 metabotropic GABA receptor binding Binding to a type 1 metabotropic GABA receptor. go.json type 1 metabotropic GABA receptor ligand http://purl.obolibrary.org/obo/GO_0031796 GO:0016178 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016178 GO:0031793 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031793 GO:0016179 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016179 GO:0031794 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031794 GO:0031791 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031791 GO:0016172 biolink:MolecularActivity obsolete antifreeze activity OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures. go.json antifreeze activity True http://purl.obolibrary.org/obo/GO_0016172 GO:0031792 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031792 GO:0016173 biolink:MolecularActivity obsolete ice nucleation inhibitor activity OBSOLETE. Inhibits the formation of ice crystals. go.json ice nucleation inhibitor activity True http://purl.obolibrary.org/obo/GO_0016173 GO:0016174 biolink:MolecularActivity NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. EC:1.6.3.1|Reactome:R-HSA-5693681|Reactome:R-HSA-9698758 go.json NAD(P)H oxidase activity|NAD(P)H:oxygen oxidoreductase activity|NADPH oxidase|THOX2 activity|ThOX activity|dual oxidase activity|p138tox|thyroid NADPH oxidase activity|thyroid oxidase 2 activity|thyroid oxidase activity http://purl.obolibrary.org/obo/GO_0016174 GO:0016175 biolink:MolecularActivity superoxide-generating NAD(P)H oxidase activity Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. Reactome:R-HSA-1222376|Reactome:R-HSA-1236967|Reactome:R-HSA-1497810|Reactome:R-HSA-5218841|Reactome:R-HSA-5668629|Reactome:R-HSA-5668718|Reactome:R-HSA-5668731|Reactome:R-HSA-6789092|Reactome:R-HSA-6807557|Reactome:R-HSA-9673797 go.json cytochrome B-245 http://purl.obolibrary.org/obo/GO_0016175 GO:0031790 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031790 GO:0031788 biolink:MolecularActivity motilin receptor binding Binding to a motilin receptor. go.json motilin receptor ligand http://purl.obolibrary.org/obo/GO_0031788 GO:0031789 biolink:MolecularActivity G protein-coupled acetylcholine receptor binding Binding to a G protein-coupled acetylcholine receptor. go.json G-protein coupled acetylcholine receptor binding|M1 muscarinic acetylcholine receptor binding|M1 muscarinic acetylcholine receptor ligand|M2 muscarinic acetylcholine receptor binding|M2 muscarinic acetylcholine receptor ligand|M3 muscarinic acetylcholine receptor binding|M3 muscarinic acetylcholine receptor ligand|M4 muscarinic acetylcholine receptor binding|M4 muscarinic acetylcholine receptor ligand|M5 muscarinic acetylcholine receptor binding|M5 muscarinic acetylcholine receptor ligand|muscarinic acetylcholine receptor binding|muscarinic acetylcholine receptor ligand http://purl.obolibrary.org/obo/GO_0031789 GO:0031786 biolink:MolecularActivity type 1B melatonin receptor binding Binding to a type 1B melatonin receptor. go.json type 1B melatonin receptor ligand http://purl.obolibrary.org/obo/GO_0031786 GO:0031787 biolink:MolecularActivity H9 melatonin receptor binding Binding to a H9 melatonin receptor. go.json H9 melatonin receptor ligand http://purl.obolibrary.org/obo/GO_0031787 GO:0090129 biolink:BiologicalProcess positive regulation of synapse maturation Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0090129 GO:0090127 biolink:BiologicalProcess positive regulation of synapse maturation by synaptic transmission Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse. go.json http://purl.obolibrary.org/obo/GO_0090127 GO:0090128 biolink:BiologicalProcess regulation of synapse maturation Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0090128 goslim_synapse GO:0016147 biolink:MolecularActivity obsolete protein-synthesizing GTPase activity, elongation OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json protein-synthesizing GTPase activity, elongation True http://purl.obolibrary.org/obo/GO_0016147 GO:0016148 biolink:MolecularActivity obsolete protein-synthesizing GTPase activity, termination OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json protein-synthesizing GTPase activity, termination True http://purl.obolibrary.org/obo/GO_0016148 GO:0016149 biolink:MolecularActivity translation release factor activity, codon specific A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. go.json http://purl.obolibrary.org/obo/GO_0016149 GO:0031784 biolink:MolecularActivity melatonin receptor binding Binding to a melatonin receptor. go.json melatonin receptor ligand http://purl.obolibrary.org/obo/GO_0031784 GO:0016143 biolink:BiologicalProcess S-glycoside metabolic process The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. go.json S-glycoside metabolism|thioglycoside metabolic process|thioglycoside metabolism http://purl.obolibrary.org/obo/GO_0016143 GO:0090121 biolink:BiologicalProcess low-density lipoprotein particle disassembly involved in cholesterol transport The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport. go.json http://purl.obolibrary.org/obo/GO_0090121 GO:0090122 biolink:BiologicalProcess cholesterol ester hydrolysis involved in cholesterol transport The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport. go.json http://purl.obolibrary.org/obo/GO_0090122 GO:0031785 biolink:MolecularActivity type 1A melatonin receptor binding Binding to a type 1A melatonin receptor. go.json type 1A melatonin receptor ligand http://purl.obolibrary.org/obo/GO_0031785 GO:0016144 biolink:BiologicalProcess S-glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. go.json S-glycoside anabolism|S-glycoside biosynthesis|S-glycoside formation|S-glycoside synthesis|thioglycoside biosynthesis|thioglycoside biosynthetic process http://purl.obolibrary.org/obo/GO_0016144 GO:0031782 biolink:MolecularActivity type 4 melanocortin receptor binding Binding to a type 4 melanocortin receptor. go.json type 4 melanocortin receptor ligand http://purl.obolibrary.org/obo/GO_0031782 GO:0016145 biolink:BiologicalProcess S-glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. go.json S-glycoside breakdown|S-glycoside catabolism|S-glycoside degradation|thioglycoside catabolic process|thioglycoside catabolism http://purl.obolibrary.org/obo/GO_0016145 GO:0090120 biolink:BiologicalProcess lysosome to ER cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum. go.json lysosome to endoplasmic reticulum cholesterol transport http://purl.obolibrary.org/obo/GO_0090120 GO:0031783 biolink:MolecularActivity type 5 melanocortin receptor binding Binding to a type 5 melanocortin receptor. go.json type 5 melanocortin receptor ligand http://purl.obolibrary.org/obo/GO_0031783 GO:0016146 biolink:MolecularActivity obsolete protein-synthesizing GTPase activity, initiation OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json protein-synthesizing GTPase activity, initiation True http://purl.obolibrary.org/obo/GO_0016146 GO:0031780 biolink:MolecularActivity corticotropin hormone receptor binding Binding to a corticotropin hormone receptor. go.json ACTH receptor binding|adrenocorticotropic hormone receptor ligand|adrenocorticotropin hormone receptor binding|adrenocorticotropin receptor binding|corticotropin receptor binding http://purl.obolibrary.org/obo/GO_0031780 GO:0090125 biolink:BiologicalProcess cell-cell adhesion involved in synapse maturation The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation. go.json trans-synaptic adhesion http://purl.obolibrary.org/obo/GO_0090125 GO:0090126 biolink:BiologicalProcess protein-containing complex assembly involved in synapse maturation The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation. go.json protein complex assembly involved in synapse maturation http://purl.obolibrary.org/obo/GO_0090126 GO:0016140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016140 GO:0031781 biolink:MolecularActivity type 3 melanocortin receptor binding Binding to a type 3 melanocortin receptor. go.json type 3 melanocortin receptor ligand http://purl.obolibrary.org/obo/GO_0031781 GO:0090123 biolink:CellularComponent lysosomal glycocalyx The polysaccharide-based coating on the inner side of a lysosomal membrane. It may be involved in protecting the membrane from digestion by lysosomal enzymes. go.json http://purl.obolibrary.org/obo/GO_0090123 GO:0016141 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016141 GO:0090124 biolink:BiologicalProcess N-4 methylation of cytosine The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0090124 GO:0016142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016142 GO:0031779 biolink:MolecularActivity melanocortin receptor binding Binding to a melanocortin receptor. go.json melanocortin receptor ligand http://purl.obolibrary.org/obo/GO_0031779 GO:0016160 biolink:MolecularActivity amylase activity Catalysis of the hydrolysis of amylose or an amylose derivative. go.json http://purl.obolibrary.org/obo/GO_0016160 GO:0031777 biolink:MolecularActivity type 1 melanin-concentrating hormone receptor binding Binding to a type 1 melanin-concentrating hormone receptor. go.json type 1 melanin-concentrating hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031777 GO:0031778 biolink:MolecularActivity type 2 melanin-concentrating hormone receptor binding Binding to a type 2 melanin-concentrating hormone receptor. go.json type 2 melanin-concentrating hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031778 GO:0031775 biolink:MolecularActivity lutropin-choriogonadotropic hormone receptor binding Binding to a lutropin-choriogonadotropic hormone receptor. go.json lutropin-choriogonadotropic hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031775 GO:0031776 biolink:MolecularActivity melanin-concentrating hormone receptor binding Binding to a melanin-concentrating hormone receptor. go.json melanin-concentrating hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031776 GO:0090138 biolink:BiologicalProcess regulation of actin cytoskeleton organization by cell-cell adhesion Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. go.json regulation of actin cytoskeleton organisation by cell-cell adhesion http://purl.obolibrary.org/obo/GO_0090138 GO:0090139 biolink:BiologicalProcess mitochondrial chromosome packaging A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure. go.json mitochondrial DNA packaging http://purl.obolibrary.org/obo/GO_0090139 GO:0016158 biolink:MolecularActivity 3-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. EC:3.1.3.8|MetaCyc:RXN0-1001|RHEA:16989 go.json 1-phytase activity|myo-inositol-hexakisphosphate 3-phosphohydrolase activity|myo-inositol-hexaphosphate 3-phosphohydrolase activity|phytase activity|phytate 1-phosphatase activity|phytate 3-phosphatase activity http://purl.obolibrary.org/obo/GO_0016158 GO:0016159 biolink:MolecularActivity muconolactone delta-isomerase activity Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate. EC:5.3.3.4|MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN|RHEA:12348 go.json 5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity|muconolactone D-isomerase activity|muconolactone isomerase activity http://purl.obolibrary.org/obo/GO_0016159 GO:0031773 biolink:MolecularActivity kisspeptin receptor binding Binding to a kisspeptin receptor. go.json G-protein coupled receptor 54 binding|KiSS-1 receptor binding|hOT7T175 receptor binding|hypogonadotropin-1 receptor binding|kisspeptin receptor ligand|metastin receptor binding http://purl.obolibrary.org/obo/GO_0031773 GO:0090132 biolink:BiologicalProcess epithelium migration The process in which the population of cells that make up an epithelium undergo directed movement. go.json http://purl.obolibrary.org/obo/GO_0090132 GO:0016154 biolink:MolecularActivity pyrimidine-nucleoside phosphorylase activity Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. EC:2.4.2.2 go.json Py-NPase activity|pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0016154 GO:0031774 biolink:MolecularActivity leukotriene receptor binding Binding to a leukotriene receptor. go.json leukotriene receptor ligand http://purl.obolibrary.org/obo/GO_0031774 GO:0016155 biolink:MolecularActivity formyltetrahydrofolate dehydrogenase activity Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH. EC:1.5.1.6|KEGG_REACTION:R00941|MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN|RHEA:10180 go.json 10-formyl tetrahydrofolate:NADP oxidoreductase activity|10-formyl-H2PtGlu:NADP oxidoreductase activity|10-formyl-H4folate dehydrogenase activity|10-formyltetrahydrofolate dehydrogenase activity|10-formyltetrahydrofolate:NADP+ oxidoreductase activity|N10-formyltetrahydrofolate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0016155 GO:0090133 biolink:BiologicalProcess mesendoderm migration The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm. go.json http://purl.obolibrary.org/obo/GO_0090133 GO:0090130 biolink:BiologicalProcess tissue migration The process in which the population of cells that make up a tissue undergo directed movement. go.json http://purl.obolibrary.org/obo/GO_0090130 GO:0016156 biolink:MolecularActivity fumarate reductase (NADH) activity Catalysis of the reaction: NAD+ + succinate = fumarate + H+ + NADH. EC:1.3.1.6|KEGG_REACTION:R00402|MetaCyc:FUMARATE-REDUCTASE-NADH-RXN|RHEA:18281 go.json NADH-dependent fumarate reductase activity http://purl.obolibrary.org/obo/GO_0016156 GO:0031771 biolink:MolecularActivity type 1 orexin receptor binding Binding to a type 1 orexin receptor. go.json OX1 orexin receptor binding|type 1 hypocretin receptor binding|type 1 hypocretin receptor ligand http://purl.obolibrary.org/obo/GO_0031771 GO:0016157 biolink:MolecularActivity sucrose synthase activity Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. EC:2.4.1.13|MetaCyc:SUCROSE-SYNTHASE-RXN go.json NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity|UDP-glucose-fructose glucosyltransferase activity|UDPglucose-fructose glucosyltransferase activity|sucrose synthetase activity|sucrose-UDP glucosyltransferase activity|sucrose-uridine diphosphate glucosyltransferase activity|uridine diphosphoglucose-fructose glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0016157 GO:0090131 biolink:BiologicalProcess mesenchyme migration The process in which the population of cells that make up a mesenchyme undergo directed movement. go.json http://purl.obolibrary.org/obo/GO_0090131 GO:0031772 biolink:MolecularActivity type 2 orexin receptor binding Binding to a type 2 orexin receptor. go.json OX2 orexin receptor binding|type 2 hypocretin receptor binding|type 2 hypocretin receptor ligand http://purl.obolibrary.org/obo/GO_0031772 GO:0016150 biolink:MolecularActivity translation release factor activity, codon nonspecific A translation release factor that is not specific to particular codons; binds to guanine nucleotides. go.json http://purl.obolibrary.org/obo/GO_0016150 GO:0090136 biolink:BiologicalProcess epithelial cell-cell adhesion The attachment of an epithelial cell to another epithelial cell via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0090136 GO:0016151 biolink:MolecularActivity nickel cation binding Binding to a nickel (Ni) cation. go.json Ni binding|nickel binding http://purl.obolibrary.org/obo/GO_0016151 GO:0090137 biolink:BiologicalProcess epithelial cell-cell adhesion involved in epithelium migration The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration. go.json http://purl.obolibrary.org/obo/GO_0090137 GO:0031770 biolink:MolecularActivity growth hormone-releasing hormone receptor binding Binding to a growth hormone-releasing hormone receptor. go.json growth hormone-releasing hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031770 GO:0016152 biolink:MolecularActivity mercury (II) reductase activity Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH. EC:1.16.1.1|KEGG_REACTION:R02807|MetaCyc:MERCURY-II-REDUCTASE-RXN|RHEA:23856|UM-BBD_reactionID:r0406 go.json Hg:NADP+ oxidoreductase activity|mer A|mercurate(II) reductase activity|mercuric ion reductase activity|mercuric reductase activity|mercury reductase activity|mercury(II) reductase activity|reduced NADP:mercuric ion oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016152 GO:0090134 biolink:BiologicalProcess cell migration involved in mesendoderm migration The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue. go.json http://purl.obolibrary.org/obo/GO_0090134 GO:0016153 biolink:MolecularActivity urocanate hydratase activity Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O. EC:4.2.1.49|KEGG_REACTION:R02914|MetaCyc:UROCANATE-HYDRATASE-RXN|RHEA:13101|Reactome:R-HSA-70903 go.json 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)|3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity|imidazolonepropionate hydrolase activity|urocanase activity http://purl.obolibrary.org/obo/GO_0016153 GO:0090135 biolink:BiologicalProcess actin filament branching The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments. go.json http://purl.obolibrary.org/obo/GO_0090135 GO:0031768 biolink:MolecularActivity ghrelin receptor binding Binding to a ghrelin receptor. go.json ghrelin receptor ligand|type 1 growth hormone secretagogue GH-releasing peptide receptor binding http://purl.obolibrary.org/obo/GO_0031768 GO:0031769 biolink:MolecularActivity glucagon receptor binding Binding to a glucagon receptor. go.json glucagon receptor ligand http://purl.obolibrary.org/obo/GO_0031769 GO:0031766 biolink:MolecularActivity type 3 galanin receptor binding Binding to a type 3 galanin receptor. go.json type 3 galanin receptor ligand http://purl.obolibrary.org/obo/GO_0031766 GO:0031767 biolink:MolecularActivity gastric inhibitory polypeptide receptor binding Binding to a gastric inhibitory polypeptide receptor. go.json gastric inhibitory polypeptide receptor ligand http://purl.obolibrary.org/obo/GO_0031767 GO:0031764 biolink:MolecularActivity type 1 galanin receptor binding Binding to a type 1 galanin receptor. go.json type 1 galanin receptor ligand http://purl.obolibrary.org/obo/GO_0031764 GO:0031765 biolink:MolecularActivity type 2 galanin receptor binding Binding to a type 2 galanin receptor. go.json type 2 galanin receptor ligand http://purl.obolibrary.org/obo/GO_0031765 GO:0016129 biolink:BiologicalProcess phytosteroid biosynthetic process The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi. go.json phytosteroid anabolism|phytosteroid biosynthesis|phytosteroid formation|phytosteroid synthesis http://purl.obolibrary.org/obo/GO_0016129 GO:0090107 biolink:BiologicalProcess regulation of high-density lipoprotein particle assembly Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. go.json http://purl.obolibrary.org/obo/GO_0090107 GO:0090108 biolink:BiologicalProcess positive regulation of high-density lipoprotein particle assembly Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. go.json http://purl.obolibrary.org/obo/GO_0090108 GO:0090105 biolink:BiologicalProcess pancreatic E cell development The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0090105 GO:0090106 biolink:BiologicalProcess pancreatic E cell fate commitment The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell. go.json http://purl.obolibrary.org/obo/GO_0090106 GO:0016125 biolink:BiologicalProcess sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json sterol metabolism http://purl.obolibrary.org/obo/GO_0016125 GO:0016126 biolink:BiologicalProcess sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. MetaCyc:PWY-2541 go.json sterol anabolism|sterol biosynthesis|sterol formation|sterol synthesis http://purl.obolibrary.org/obo/GO_0016126 GO:0016127 biolink:BiologicalProcess sterol catabolic process The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json sterol breakdown|sterol catabolism|sterol degradation http://purl.obolibrary.org/obo/GO_0016127 GO:0090109 biolink:BiologicalProcess regulation of cell-substrate junction assembly Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. go.json http://purl.obolibrary.org/obo/GO_0090109 GO:0016128 biolink:BiologicalProcess phytosteroid metabolic process The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi. go.json phytosteroid metabolism http://purl.obolibrary.org/obo/GO_0016128 GO:0016121 biolink:BiologicalProcess carotene catabolic process The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids. go.json carotene breakdown|carotene catabolism|carotene degradation http://purl.obolibrary.org/obo/GO_0016121 GO:0031762 biolink:MolecularActivity follicle-stimulating hormone receptor binding Binding to a follicle-stimulating hormone receptor. go.json FSH receptor binding|follicle stimulating hormone receptor binding|follicle stimulating hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031762 GO:0016122 biolink:BiologicalProcess xanthophyll metabolic process The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids. go.json xanthophyll metabolism http://purl.obolibrary.org/obo/GO_0016122 GO:0031763 biolink:MolecularActivity galanin receptor binding Binding to a galanin receptor. go.json galanin receptor ligand http://purl.obolibrary.org/obo/GO_0031763 GO:0090100 biolink:BiologicalProcess positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. go.json positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway http://purl.obolibrary.org/obo/GO_0090100 GO:0016123 biolink:BiologicalProcess xanthophyll biosynthetic process The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids. go.json xanthophyll anabolism|xanthophyll biosynthesis|xanthophyll formation|xanthophyll synthesis http://purl.obolibrary.org/obo/GO_0016123 GO:0031760 biolink:MolecularActivity Edg-7 lysophosphatidic acid receptor binding Binding to an Edg-7 lysophosphatidic acid receptor. go.json Edg-7 lysophosphatidic acid receptor ligand|LPA3 receptor binding http://purl.obolibrary.org/obo/GO_0031760 GO:0031761 biolink:MolecularActivity fMet-Leu-Phe receptor binding Binding to a fMet-Leu-Phe receptor. go.json N-formyl peptide receptor binding|fMet-Leu-Phe receptor ligand http://purl.obolibrary.org/obo/GO_0031761 GO:0016124 biolink:BiologicalProcess xanthophyll catabolic process The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids. go.json xanthophyll breakdown|xanthophyll catabolism|xanthophyll degradation http://purl.obolibrary.org/obo/GO_0016124 GO:0090103 biolink:BiologicalProcess cochlea morphogenesis The process in which the cochlea is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0090103 GO:0090104 biolink:BiologicalProcess pancreatic epsilon cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin. go.json pancreatic E cell differentiation http://purl.obolibrary.org/obo/GO_0090104 GO:0090101 biolink:BiologicalProcess negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. go.json negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway http://purl.obolibrary.org/obo/GO_0090101 GO:0016120 biolink:BiologicalProcess carotene biosynthetic process The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids. go.json carotene anabolism|carotene biosynthesis|carotene formation|carotene synthesis http://purl.obolibrary.org/obo/GO_0016120 GO:0090102 biolink:BiologicalProcess cochlea development The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. go.json http://purl.obolibrary.org/obo/GO_0090102 GO:0031759 biolink:MolecularActivity Edg-6 sphingosine 1-phosphate receptor binding Binding to an Edg-6 sphingosine 1-phosphate receptor. go.json Edg-6 sphingosine 1-phosphate receptor ligand http://purl.obolibrary.org/obo/GO_0031759 GO:0031757 biolink:MolecularActivity Edg-4 lysophosphatidic acid receptor binding Binding to an Edg-4 lysophosphatidic acid receptor. go.json Edg-4 lysophosphatidic acid receptor ligand|LPA2 receptor binding http://purl.obolibrary.org/obo/GO_0031757 GO:0031758 biolink:MolecularActivity Edg-5 sphingosine 1-phosphate receptor binding Binding to an Edg-5 sphingosine 1-phosphate receptor. go.json Edg-5 sphingosine 1-phosphate receptor ligand http://purl.obolibrary.org/obo/GO_0031758 GO:0031755 biolink:MolecularActivity Edg-2 lysophosphatidic acid receptor binding Binding to an Edg-2 lysophosphatidic acid receptor. go.json Edg-2 lysophosphatidic acid receptor ligand|LPA1 receptor binding http://purl.obolibrary.org/obo/GO_0031755 GO:0031756 biolink:MolecularActivity Edg-3 sphingosine 1-phosphate receptor binding Binding to an Edg-3 sphingosine 1-phosphate receptor. go.json Edg-3 sphingosine 1-phosphate receptor ligand http://purl.obolibrary.org/obo/GO_0031756 GO:0031753 biolink:MolecularActivity endothelial differentiation G protein-coupled receptor binding Binding to an endothelial differentiation G protein-coupled receptor. go.json endothelial differentiation G-protein coupled receptor binding|endothelial differentiation G-protein coupled receptor ligand http://purl.obolibrary.org/obo/GO_0031753 GO:0031754 biolink:MolecularActivity Edg-1 sphingosine 1-phosphate receptor binding Binding to an Edg-1 sphingosine 1-phosphate receptor. go.json Edg-1 sphingosine 1-phosphate receptor ligand http://purl.obolibrary.org/obo/GO_0031754 GO:0090118 biolink:BiologicalProcess receptor-mediated endocytosis involved in cholesterol transport A receptor-mediated endocytosis process involved in intracellular cholesterol transport. go.json receptor-mediated endocytosis involved in intracellular cholesterol transport|receptor-mediated endocytosis of LDL|receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport http://purl.obolibrary.org/obo/GO_0090118 GO:0090119 biolink:BiologicalProcess vesicle-mediated cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles. go.json http://purl.obolibrary.org/obo/GO_0090119 GO:0090116 biolink:BiologicalProcess C-5 methylation of cytosine The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0090116 GO:0090117 biolink:BiologicalProcess endosome to lysosome transport of low-density lipoprotein particle The directed movement of low-density lipoprotein particle from endosomes to lysosomes. go.json endosome to lysosome transport of LDL http://purl.obolibrary.org/obo/GO_0090117 GO:0016136 biolink:BiologicalProcess saponin catabolic process The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. go.json saponin breakdown|saponin catabolism|saponin degradation http://purl.obolibrary.org/obo/GO_0016136 GO:0016137 biolink:BiologicalProcess glycoside metabolic process The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. go.json O-glycoside metabolic process|O-glycoside metabolism|glycoside metabolism http://purl.obolibrary.org/obo/GO_0016137 GO:0016138 biolink:BiologicalProcess glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. go.json O-glycoside anabolism|O-glycoside biosynthesis|O-glycoside biosynthetic process|O-glycoside formation|O-glycoside synthesis|glycoside anabolism|glycoside biosynthesis|glycoside formation|glycoside synthesis http://purl.obolibrary.org/obo/GO_0016138 GO:0016139 biolink:BiologicalProcess glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. go.json O-glycoside breakdown|O-glycoside catabolic process|O-glycoside catabolism|O-glycoside degradation|glycoside breakdown|glycoside catabolism|glycoside degradation http://purl.obolibrary.org/obo/GO_0016139 GO:0090110 biolink:BiologicalProcess COPII-coated vesicle cargo loading The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi. go.json COPII coat-cargo complex assembly|cargo loading into COPII vesicle|cargo loading into COPII-coated vesicle|cargo selection into COPII-coated vesicle http://purl.obolibrary.org/obo/GO_0090110 GO:0016132 biolink:BiologicalProcess brassinosteroid biosynthetic process The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. MetaCyc:PWY-2582|MetaCyc:PWY-699 go.json brassinosteroid anabolism|brassinosteroid biosynthesis|brassinosteroid formation|brassinosteroid synthesis http://purl.obolibrary.org/obo/GO_0016132 GO:0031751 biolink:MolecularActivity D4 dopamine receptor binding Binding to a D4 dopamine receptor. go.json D4 dopamine receptor ligand http://purl.obolibrary.org/obo/GO_0031751 GO:0016133 biolink:BiologicalProcess brassinosteroid catabolic process The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. go.json brassinosteroid breakdown|brassinosteroid catabolism|brassinosteroid degradation http://purl.obolibrary.org/obo/GO_0016133 GO:0031752 biolink:MolecularActivity D5 dopamine receptor binding Binding to a D5 dopamine receptor. go.json D1B dopamine receptor binding|D5 dopamine receptor ligand http://purl.obolibrary.org/obo/GO_0031752 GO:0090111 biolink:BiologicalProcess regulation of COPII vesicle uncoating Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released. go.json http://purl.obolibrary.org/obo/GO_0090111 GO:0016134 biolink:BiologicalProcess saponin metabolic process The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. go.json saponin metabolism http://purl.obolibrary.org/obo/GO_0016134 GO:0016135 biolink:BiologicalProcess saponin biosynthetic process The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. go.json saponin anabolism|saponin biosynthesis|saponin formation|saponin synthesis http://purl.obolibrary.org/obo/GO_0016135 GO:0031750 biolink:MolecularActivity D3 dopamine receptor binding Binding to a D3 dopamine receptor. go.json D3 dopamine receptor ligand http://purl.obolibrary.org/obo/GO_0031750 GO:0090114 biolink:BiologicalProcess COPII-coated vesicle budding The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle. go.json COPII vesicle budding|ER exit|ER vesicle budding http://purl.obolibrary.org/obo/GO_0090114 GO:0090115 biolink:BiologicalProcess obsolete C-5 methylation on cytosine involved in chromatin silencing OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing. go.json True http://purl.obolibrary.org/obo/GO_0090115 GO:0016130 biolink:BiologicalProcess phytosteroid catabolic process The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi. go.json phytosteroid breakdown|phytosteroid catabolism|phytosteroid degradation http://purl.obolibrary.org/obo/GO_0016130 GO:0090112 biolink:BiologicalProcess COPII vesicle uncoating The process in which COPII vesicle coat proteins are disassembled, and released. go.json http://purl.obolibrary.org/obo/GO_0090112 GO:0016131 biolink:BiologicalProcess brassinosteroid metabolic process The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. go.json brassinosteroid metabolism http://purl.obolibrary.org/obo/GO_0016131 GO:0090113 biolink:BiologicalProcess obsolete regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis OBSOLETE. The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. go.json True http://purl.obolibrary.org/obo/GO_0090113 GO:0100050 biolink:BiologicalProcess obsolete negative regulation of mating type switching by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates mating type switching. go.json True http://purl.obolibrary.org/obo/GO_0100050 GO:0100051 biolink:BiologicalProcess obsolete positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates meiotic nuclear division. go.json True http://purl.obolibrary.org/obo/GO_0100051 GO:0100052 biolink:BiologicalProcess obsolete negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates G1/S transition of mitotic cell cycle. go.json True http://purl.obolibrary.org/obo/GO_0100052 GO:0100053 biolink:BiologicalProcess obsolete positive regulation of sulfate assimilation by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sulfate assimilation. go.json True http://purl.obolibrary.org/obo/GO_0100053 GO:0100054 biolink:BiologicalProcess obsolete positive regulation of flocculation via cell wall protein-carbohydrate interaction by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates flocculation via cell wall protein-carbohydrate interaction. go.json True http://purl.obolibrary.org/obo/GO_0100054 GO:0100055 biolink:BiologicalProcess obsolete positive regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phosphatidylserine biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100055 GO:0100056 biolink:BiologicalProcess obsolete negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phosphatidylserine biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100056 GO:0100057 biolink:BiologicalProcess obsolete regulation of phenotypic switching by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates phenotypic switching. go.json True http://purl.obolibrary.org/obo/GO_0100057 GO:0100058 biolink:BiologicalProcess obsolete positive regulation of phenotypic switching by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phenotypic switching. go.json True http://purl.obolibrary.org/obo/GO_0100058 GO:0100059 biolink:BiologicalProcess obsolete negative regulation of phenotypic switching by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phenotypic switching. go.json True http://purl.obolibrary.org/obo/GO_0100059 GO:0100060 biolink:MolecularActivity obsolete negative regulation of SREBP signaling pathway by DNA binding OBSOLETE. Any DNA binding that negatively regulates SREBP signaling pathway. go.json True http://purl.obolibrary.org/obo/GO_0100060 GO:0100061 biolink:BiologicalProcess obsolete negative regulation of SREBP signaling pathway by transcription factor catabolic process OBSOLETE. Any transcription factor catabolic process process that negatively regulates SREBP signaling pathway. go.json True http://purl.obolibrary.org/obo/GO_0100061 GO:0100062 biolink:BiologicalProcess obsolete positive regulation of SREBP signaling pathway by transcription factor catabolic process OBSOLETE. Any transcription factor catabolic process process that positively_regulates SREBP signaling pathway. go.json True http://purl.obolibrary.org/obo/GO_0100062 GO:0100063 biolink:BiologicalProcess obsolete regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates dipeptide transmembrane transport. go.json True http://purl.obolibrary.org/obo/GO_0100063 GO:0100064 biolink:BiologicalProcess obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates filamentous growth of a population of unicellular organisms in response to starvation. go.json True http://purl.obolibrary.org/obo/GO_0100064 GO:0100065 biolink:BiologicalProcess obsolete negative regulation of leucine import by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates leucine import. go.json True http://purl.obolibrary.org/obo/GO_0100065 GO:0100066 biolink:BiologicalProcess obsolete negative regulation of induction of conjugation with cellular fusion by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates induction of conjugation with cellular fusion. go.json True http://purl.obolibrary.org/obo/GO_0100066 GO:0100067 biolink:BiologicalProcess positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway Any canonical Wnt signaling pathway process that positively_regulates spinal cord association neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_0100067 GO:0100068 biolink:BiologicalProcess obsolete positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates pyrimidine-containing compound salvage. go.json True http://purl.obolibrary.org/obo/GO_0100068 GO:0100069 biolink:BiologicalProcess obsolete negative regulation of neuron apoptotic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates neuron apoptotic process. go.json True http://purl.obolibrary.org/obo/GO_0100069 GO:0100070 biolink:BiologicalProcess obsolete obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fatty acid biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100070 GO:0100010 biolink:BiologicalProcess positive regulation of fever generation by prostaglandin biosynthetic process Any prostaglandin biosynthetic process process that positively_regulates fever generation. go.json http://purl.obolibrary.org/obo/GO_0100010 GO:0100011 biolink:BiologicalProcess positive regulation of fever generation by prostaglandin secretion Any prostaglandin secretion process that positively_regulates fever generation. go.json http://purl.obolibrary.org/obo/GO_0100011 GO:0100012 biolink:BiologicalProcess regulation of heart induction by canonical Wnt signaling pathway Any canonical Wnt signaling pathway process that regulates heart induction. go.json http://purl.obolibrary.org/obo/GO_0100012 GO:0100013 biolink:BiologicalProcess obsolete positive regulation of fatty acid beta-oxidation by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates fatty acid beta-oxidation. go.json True http://purl.obolibrary.org/obo/GO_0100013 GO:0100014 biolink:BiologicalProcess obsolete positive regulation of mating type switching by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates mating type switching. go.json True http://purl.obolibrary.org/obo/GO_0100014 GO:0100015 biolink:BiologicalProcess obsolete positive regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates inositol biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100015 GO:0100016 biolink:BiologicalProcess obsolete regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates thiamine biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100016 GO:0100017 biolink:BiologicalProcess obsolete negative regulation of cell-cell adhesion by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates single organismal cell-cell adhesion. go.json True http://purl.obolibrary.org/obo/GO_0100017 GO:0100018 biolink:BiologicalProcess obsolete regulation of glucose import by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates glucose import. go.json True http://purl.obolibrary.org/obo/GO_0100018 GO:0100019 biolink:BiologicalProcess obsolete regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cAMP-mediated signaling. go.json True http://purl.obolibrary.org/obo/GO_0100019 GO:0100020 biolink:BiologicalProcess obsolete regulation of transport by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates transport. go.json True http://purl.obolibrary.org/obo/GO_0100020 GO:0100021 biolink:BiologicalProcess obsolete regulation of iron ion transport by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates iron ion transport. go.json regulation of iron ion import by transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0100021 GO:0100022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0100022 GO:0100023 biolink:BiologicalProcess obsolete regulation of meiotic nuclear division by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates meiotic nuclear division. go.json True http://purl.obolibrary.org/obo/GO_0100023 GO:0100024 biolink:BiologicalProcess obsolete regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates carbohydrate metabolic process. go.json True http://purl.obolibrary.org/obo/GO_0100024 GO:0100025 biolink:BiologicalProcess obsolete negative regulation of cellular amino acid biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular amino acid biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100025 GO:0100026 biolink:BiologicalProcess obsolete positive regulation of DNA repair by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates DNA repair. go.json True http://purl.obolibrary.org/obo/GO_0100026 GO:0100027 biolink:BiologicalProcess obsolete regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cell separation after cytokinesis. go.json True http://purl.obolibrary.org/obo/GO_0100027 GO:0100028 biolink:BiologicalProcess obsolete regulation of conjugation with cellular fusion by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates conjugation with cellular fusion. go.json True http://purl.obolibrary.org/obo/GO_0100028 GO:0100029 biolink:BiologicalProcess obsolete regulation of histone modification by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone modification. go.json True http://purl.obolibrary.org/obo/GO_0100029 GO:0100030 biolink:BiologicalProcess obsolete regulation of histone acetylation by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone acetylation. go.json True http://purl.obolibrary.org/obo/GO_0100030 GO:0100031 biolink:BiologicalProcess obsolete regulation of histone methylation by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone methylation. go.json True http://purl.obolibrary.org/obo/GO_0100031 GO:0100032 biolink:BiologicalProcess obsolete positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phospholipid biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100032 GO:0100033 biolink:BiologicalProcess obsolete regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fungal-type cell wall biogenesis. go.json True http://purl.obolibrary.org/obo/GO_0100033 GO:0100034 biolink:BiologicalProcess obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates 4,6-pyruvylated galactose residue biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100034 GO:0100035 biolink:BiologicalProcess obsolete negative regulation of transmembrane transport by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates transmembrane transport. go.json True http://purl.obolibrary.org/obo/GO_0100035 GO:0100036 biolink:BiologicalProcess obsolete positive regulation of purine nucleotide biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates purine nucleotide biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100036 GO:0100037 biolink:BiologicalProcess obsolete positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates cellular alcohol catabolic process. go.json True http://purl.obolibrary.org/obo/GO_0100037 GO:0100038 biolink:BiologicalProcess obsolete regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cellular response to oxidative stress. go.json True http://purl.obolibrary.org/obo/GO_0100038 GO:0100039 biolink:BiologicalProcess obsolete regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates pyrimidine nucleotide biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100039 GO:0100040 biolink:BiologicalProcess obsolete negative regulation of invasive growth in response to glucose limitation by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates invasive growth in response to glucose limitation. go.json True http://purl.obolibrary.org/obo/GO_0100040 GO:0100041 biolink:BiologicalProcess obsolete positive regulation of pseudohyphal growth by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates pseudohyphal growth. go.json True http://purl.obolibrary.org/obo/GO_0100041 GO:0100042 biolink:BiologicalProcess obsolete negative regulation of pseudohyphal growth by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates pseudohyphal growth. go.json True http://purl.obolibrary.org/obo/GO_0100042 GO:0100043 biolink:BiologicalProcess obsolete negative regulation of cellular response to alkaline pH by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular response to alkaline pH. go.json True http://purl.obolibrary.org/obo/GO_0100043 GO:0100044 biolink:BiologicalProcess obsolete negative regulation of cellular hyperosmotic salinity response by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular hyperosmotic salinity response. go.json True http://purl.obolibrary.org/obo/GO_0100044 GO:0100045 biolink:BiologicalProcess obsolete negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates arginine catabolic process. go.json True http://purl.obolibrary.org/obo/GO_0100045 GO:0100046 biolink:BiologicalProcess obsolete positive regulation of arginine biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates arginine biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100046 GO:0100047 biolink:BiologicalProcess obsolete negative regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates inositol biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100047 GO:0100048 biolink:BiologicalProcess obsolete positive regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phosphatidylcholine biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100048 GO:0100049 biolink:BiologicalProcess obsolete negative regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phosphatidylcholine biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_0100049 GO:0006704 biolink:BiologicalProcess glucocorticoid biosynthetic process The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. go.json glucocorticoid anabolism|glucocorticoid biosynthesis|glucocorticoid formation|glucocorticoid synthesis http://purl.obolibrary.org/obo/GO_0006704 GO:0006705 biolink:BiologicalProcess mineralocorticoid biosynthetic process The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. go.json mineralocorticoid anabolism|mineralocorticoid biosynthesis|mineralocorticoid formation|mineralocorticoid synthesis http://purl.obolibrary.org/obo/GO_0006705 GO:0006702 biolink:BiologicalProcess androgen biosynthetic process The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. go.json androgen anabolism|androgen biosynthesis|androgen formation|androgen synthesis http://purl.obolibrary.org/obo/GO_0006702 GO:0006703 biolink:BiologicalProcess estrogen biosynthetic process The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. go.json estrogen anabolism|estrogen biosynthesis|estrogen formation|estrogen synthesis|oestrogen biosynthesis|oestrogen biosynthetic process http://purl.obolibrary.org/obo/GO_0006703 GO:0006700 biolink:BiologicalProcess C21-steroid hormone biosynthetic process The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. go.json C21-steroid hormone anabolism|C21-steroid hormone biosynthesis|C21-steroid hormone formation|C21-steroid hormone synthesis http://purl.obolibrary.org/obo/GO_0006700 GO:0006701 biolink:BiologicalProcess progesterone biosynthetic process The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. go.json progesterone anabolism|progesterone biosynthesis|progesterone formation|progesterone synthesis http://purl.obolibrary.org/obo/GO_0006701 GO:0006708 biolink:BiologicalProcess ecdysone catabolic process The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. go.json ecdysone breakdown|ecdysone catabolism|ecdysone degradation http://purl.obolibrary.org/obo/GO_0006708 GO:0006709 biolink:BiologicalProcess progesterone catabolic process The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. go.json progesterone breakdown|progesterone catabolism|progesterone degradation http://purl.obolibrary.org/obo/GO_0006709 GO:0006706 biolink:BiologicalProcess steroid catabolic process The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. go.json steroid breakdown|steroid catabolism|steroid degradation http://purl.obolibrary.org/obo/GO_0006706 GO:0006707 biolink:BiologicalProcess cholesterol catabolic process The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json cholesterol breakdown|cholesterol catabolism|cholesterol degradation http://purl.obolibrary.org/obo/GO_0006707 GO:0006715 biolink:BiologicalProcess farnesol biosynthetic process The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. go.json farnesol anabolism|farnesol biosynthesis|farnesol formation|farnesol synthesis http://purl.obolibrary.org/obo/GO_0006715 GO:0006716 biolink:BiologicalProcess juvenile hormone metabolic process The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. go.json juvenile hormone metabolism http://purl.obolibrary.org/obo/GO_0006716 GO:0006713 biolink:BiologicalProcess glucocorticoid catabolic process The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. go.json glucocorticoid breakdown|glucocorticoid catabolism|glucocorticoid degradation http://purl.obolibrary.org/obo/GO_0006713 GO:0006714 biolink:BiologicalProcess sesquiterpenoid metabolic process The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units. go.json sesquiterpenoid metabolism http://purl.obolibrary.org/obo/GO_0006714 GO:0006711 biolink:BiologicalProcess estrogen catabolic process The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. go.json estrogen breakdown|estrogen catabolism|estrogen degradation|oestrogen catabolic process|oestrogen catabolism http://purl.obolibrary.org/obo/GO_0006711 GO:0006712 biolink:BiologicalProcess mineralocorticoid catabolic process The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. go.json mineralocorticoid breakdown|mineralocorticoid catabolism|mineralocorticoid degradation http://purl.obolibrary.org/obo/GO_0006712 GO:0006710 biolink:BiologicalProcess androgen catabolic process The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. go.json androgen breakdown|androgen catabolism|androgen degradation http://purl.obolibrary.org/obo/GO_0006710 GO:0006719 biolink:BiologicalProcess juvenile hormone catabolic process The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. go.json juvenile hormone breakdown|juvenile hormone catabolism|juvenile hormone degradation http://purl.obolibrary.org/obo/GO_0006719 GO:0006717 biolink:BiologicalProcess obsolete juvenile hormone binding OBSOLETE. (Was not defined before being made obsolete). go.json juvenile hormone binding True http://purl.obolibrary.org/obo/GO_0006717 GO:0006718 biolink:BiologicalProcess juvenile hormone biosynthetic process The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. go.json juvenile hormone anabolism|juvenile hormone biosynthesis|juvenile hormone formation|juvenile hormone synthesis http://purl.obolibrary.org/obo/GO_0006718 GO:0031748 biolink:MolecularActivity D1 dopamine receptor binding Binding to a D1 dopamine receptor. go.json D1 dopamine receptor ligand|D1A dopamine receptor binding http://purl.obolibrary.org/obo/GO_0031748 GO:0031749 biolink:MolecularActivity D2 dopamine receptor binding Binding to a D2 dopamine receptor. go.json D2 dopamine receptor ligand http://purl.obolibrary.org/obo/GO_0031749 GO:0031746 biolink:MolecularActivity type 1 cysteinyl leukotriene receptor binding Binding to a type 1 cysteinyl leukotriene receptor. go.json type 1 cysteinyl leukotriene receptor ligand http://purl.obolibrary.org/obo/GO_0031746 GO:0031747 biolink:MolecularActivity type 2 cysteinyl leukotriene receptor binding Binding to a type 2 cysteinyl leukotriene receptor. go.json type 2 cysteinyl leukotriene receptor ligand http://purl.obolibrary.org/obo/GO_0031747 GO:0006788 biolink:BiologicalProcess heme oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. go.json haem oxidation http://purl.obolibrary.org/obo/GO_0006788 GO:0090040 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090040 GO:0031744 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031744 GO:0006789 biolink:BiologicalProcess bilirubin conjugation The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin. go.json http://purl.obolibrary.org/obo/GO_0006789 GO:0090041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090041 GO:0031745 biolink:MolecularActivity cysteinyl leukotriene receptor binding Binding to a cysteinyl leukotriene receptor. go.json cysteinyl leukotriene receptor ligand http://purl.obolibrary.org/obo/GO_0031745 GO:0006786 biolink:BiologicalProcess heme C biosynthetic process The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f. go.json haem C biosynthesis|haem C biosynthetic process|heme C anabolism|heme C biosynthesis|heme C formation|heme C synthesis http://purl.obolibrary.org/obo/GO_0006786 GO:0031742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031742 GO:0006787 biolink:BiologicalProcess porphyrin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. go.json porphyrin breakdown|porphyrin catabolic process|porphyrin catabolism|porphyrin degradation http://purl.obolibrary.org/obo/GO_0006787 GO:0031743 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031743 GO:0006784 biolink:BiologicalProcess heme A biosynthetic process The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3. go.json haem A biosynthesis|haem A biosynthetic process|heme A anabolism|heme A biosynthesis|heme A formation|heme A synthesis http://purl.obolibrary.org/obo/GO_0006784 GO:0006785 biolink:BiologicalProcess heme B biosynthetic process The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. go.json haem B biosynthesis|haem B biosynthetic process|heme B anabolism|heme B biosynthesis|heme B formation|heme B synthesis|protoheme biosynthesis|protoheme biosynthetic process http://purl.obolibrary.org/obo/GO_0006785 GO:0006782 biolink:BiologicalProcess protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. go.json protoporphyrinogen IX anabolism|protoporphyrinogen IX biosynthesis|protoporphyrinogen IX formation|protoporphyrinogen IX synthesis http://purl.obolibrary.org/obo/GO_0006782 GO:0006783 biolink:BiologicalProcess heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. MetaCyc:HEMESYN2-PWY go.json haem biosynthesis|haem biosynthetic process|heme anabolism|heme biosynthesis|heme formation|heme synthesis http://purl.obolibrary.org/obo/GO_0006783 GO:0006780 biolink:BiologicalProcess uroporphyrinogen III biosynthetic process The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. go.json uroporphyrinogen III anabolism|uroporphyrinogen III biosynthesis|uroporphyrinogen III formation|uroporphyrinogen III synthesis http://purl.obolibrary.org/obo/GO_0006780 GO:0006781 biolink:BiologicalProcess succinyl-CoA pathway The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX. go.json biosynthesis of protoporphyrin IX via succinyl CoA|biosynthesis of protoporphyrin IX via succinyl-CoA|biosynthetic process of protoporphyrin IX via succinyl CoA|biosynthetic process of protoporphyrin IX via succinyl-CoA|succinyl CoA pathway http://purl.obolibrary.org/obo/GO_0006781 GO:0016107 biolink:BiologicalProcess sesquiterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units. go.json sesquiterpenoid breakdown|sesquiterpenoid catabolism|sesquiterpenoid degradation http://purl.obolibrary.org/obo/GO_0016107 GO:0016108 biolink:BiologicalProcess tetraterpenoid metabolic process The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units. go.json tetraterpene metabolic process|tetraterpene metabolism|tetraterpenoid metabolism http://purl.obolibrary.org/obo/GO_0016108 GO:0016109 biolink:BiologicalProcess tetraterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units. go.json tetraterpene biosynthesis|tetraterpene biosynthetic process|tetraterpenoid anabolism|tetraterpenoid biosynthesis|tetraterpenoid formation|tetraterpenoid synthesis http://purl.obolibrary.org/obo/GO_0016109 GO:0016103 biolink:BiologicalProcess diterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units. go.json diterpene catabolic process|diterpene catabolism|diterpenoid breakdown|diterpenoid catabolism|diterpenoid degradation http://purl.obolibrary.org/obo/GO_0016103 GO:0016104 biolink:BiologicalProcess triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units. go.json triterpene biosynthesis|triterpene biosynthetic process|triterpenoid anabolism|triterpenoid biosynthesis|triterpenoid formation|triterpenoid synthesis http://purl.obolibrary.org/obo/GO_0016104 GO:0016105 biolink:BiologicalProcess triterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units. go.json triterpene catabolic process|triterpene catabolism|triterpenoid breakdown|triterpenoid catabolism|triterpenoid degradation http://purl.obolibrary.org/obo/GO_0016105 GO:0016106 biolink:BiologicalProcess sesquiterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units. go.json sesquiterpenoid anabolism|sesquiterpenoid biosynthesis|sesquiterpenoid formation|sesquiterpenoid synthesis http://purl.obolibrary.org/obo/GO_0016106 GO:0090044 biolink:BiologicalProcess positive regulation of tubulin deacetylation Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. go.json http://purl.obolibrary.org/obo/GO_0090044 GO:0031740 biolink:MolecularActivity type A cholecystokinin receptor binding Binding to a type A cholecystokinin receptor. go.json type A cholecystokinin receptor ligand http://purl.obolibrary.org/obo/GO_0031740 GO:0016100 biolink:BiologicalProcess monoterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton. go.json monoterpenoid breakdown|monoterpenoid catabolism|monoterpenoid degradation http://purl.obolibrary.org/obo/GO_0016100 GO:0090045 biolink:BiologicalProcess positive regulation of deacetylase activity Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0090045 gocheck_do_not_annotate GO:0031741 biolink:MolecularActivity type B gastrin/cholecystokinin receptor binding Binding to a type B gastrin/cholecystokinin receptor. go.json type B gastrin/cholecystokinin receptor ligand http://purl.obolibrary.org/obo/GO_0031741 GO:0016101 biolink:BiologicalProcess diterpenoid metabolic process The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units. go.json diterpene metabolic process|diterpene metabolism|diterpenoid metabolism http://purl.obolibrary.org/obo/GO_0016101 GO:0090042 biolink:BiologicalProcess tubulin deacetylation The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json http://purl.obolibrary.org/obo/GO_0090042 gocheck_do_not_annotate GO:0016102 biolink:BiologicalProcess diterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units. go.json diterpene biosynthesis|diterpene biosynthetic process|diterpenoid anabolism|diterpenoid biosynthesis|diterpenoid formation|diterpenoid synthesis http://purl.obolibrary.org/obo/GO_0016102 GO:0090043 biolink:BiologicalProcess regulation of tubulin deacetylation Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. go.json http://purl.obolibrary.org/obo/GO_0090043 GO:0090048 biolink:BiologicalProcess obsolete negative regulation of transcription regulator activity OBSOLETE. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. go.json negative regulation of transcription regulator activity True http://purl.obolibrary.org/obo/GO_0090048 GO:0090049 biolink:BiologicalProcess regulation of cell migration involved in sprouting angiogenesis Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0090049 GO:0090046 biolink:BiologicalProcess obsolete regulation of transcription regulator activity OBSOLETE. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. go.json regulation of transcription regulator activity True http://purl.obolibrary.org/obo/GO_0090046 GO:0090047 biolink:BiologicalProcess obsolete positive regulation of transcription regulator activity OBSOLETE. Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. go.json positive regulation of transcription regulator activity True http://purl.obolibrary.org/obo/GO_0090047 GO:0031737 biolink:MolecularActivity CX3C chemokine receptor binding Binding to a CX3C chemokine receptor. go.json CX3C chemokine receptor ligand|fractalkine receptor binding http://purl.obolibrary.org/obo/GO_0031737 GO:0031738 biolink:MolecularActivity XCR1 chemokine receptor binding Binding to a XCR1 chemokine receptor. go.json XCR1 chemokine receptor ligand|lymphotactin receptor binding http://purl.obolibrary.org/obo/GO_0031738 GO:0031735 biolink:MolecularActivity CCR10 chemokine receptor binding Binding to a CCR10 chemokine receptor. go.json CCR10 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0031735 GO:0031736 biolink:MolecularActivity CCR11 chemokine receptor binding Binding to a CCR11 chemokine receptor. go.json CCR11 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0031736 GO:0006799 biolink:BiologicalProcess polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. go.json polyphosphate anabolism|polyphosphate biosynthesis|polyphosphate formation|polyphosphate synthesis http://purl.obolibrary.org/obo/GO_0006799 GO:0090051 biolink:BiologicalProcess negative regulation of cell migration involved in sprouting angiogenesis Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0090051 GO:0031733 biolink:MolecularActivity CCR8 chemokine receptor binding Binding to a CCR8 chemokine receptor. go.json CCR8 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0031733 GO:0090052 biolink:BiologicalProcess regulation of pericentric heterochromatin formation Any process that modulates the frequency, rate or extent of heterochromatin formation at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin. go.json regulation of chromatin silencing at centromere|regulation of pericentric heterochromatin assembly http://purl.obolibrary.org/obo/GO_0090052 GO:0031734 biolink:MolecularActivity CCR9 chemokine receptor binding Binding to a CCR9 chemokine receptor. go.json CCR9 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0031734 GO:0031731 biolink:MolecularActivity CCR6 chemokine receptor binding Binding to a CCR6 chemokine receptor. go.json CCR6 chemokine receptor ligand|LARC receptor binding http://purl.obolibrary.org/obo/GO_0031731 GO:0006797 biolink:BiologicalProcess polyphosphate metabolic process The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid. go.json polyphosphate metabolism http://purl.obolibrary.org/obo/GO_0006797 GO:0006798 biolink:BiologicalProcess polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid. go.json polyphosphate breakdown|polyphosphate catabolism|polyphosphate degradation http://purl.obolibrary.org/obo/GO_0006798 GO:0090050 biolink:BiologicalProcess positive regulation of cell migration involved in sprouting angiogenesis Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0090050 GO:0031732 biolink:MolecularActivity CCR7 chemokine receptor binding Binding to a CCR7 chemokine receptor. go.json CCR7 chemokine receptor ligand|MIP-3 beta receptor binding|type 1 EBV-induced G-protein coupled receptor binding http://purl.obolibrary.org/obo/GO_0031732 GO:0006795 biolink:BiologicalProcess regulation of phosphorus utilization Any process that modulates the frequency, rate or extent of phosphorus utilization. go.json http://purl.obolibrary.org/obo/GO_0006795 GO:0006796 biolink:BiologicalProcess phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. go.json phosphate metabolic process|phosphate metabolism http://purl.obolibrary.org/obo/GO_0006796 GO:0006793 biolink:BiologicalProcess phosphorus metabolic process The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). go.json phosphorus metabolism http://purl.obolibrary.org/obo/GO_0006793 goslim_pir GO:0006794 biolink:BiologicalProcess phosphorus utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism. go.json http://purl.obolibrary.org/obo/GO_0006794 GO:0006791 biolink:BiologicalProcess sulfur utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism. go.json sulphur utilization http://purl.obolibrary.org/obo/GO_0006791 GO:0006792 biolink:BiologicalProcess regulation of sulfur utilization Any process that modulates the frequency, rate or extent of sulfur utilization. go.json regulation of sulphur utilization http://purl.obolibrary.org/obo/GO_0006792 GO:0031739 biolink:MolecularActivity cholecystokinin receptor binding Binding to a cholecystokinin receptor. go.json cholecystokinin receptor ligand http://purl.obolibrary.org/obo/GO_0031739 GO:0006790 biolink:BiologicalProcess sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. Wikipedia:Sulfur_metabolism go.json sulfur metabolism|sulphur metabolic process|sulphur metabolism http://purl.obolibrary.org/obo/GO_0006790 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|prokaryote_subset GO:0016118 biolink:BiologicalProcess carotenoid catabolic process The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. go.json carotenoid breakdown|carotenoid catabolism|carotenoid degradation http://purl.obolibrary.org/obo/GO_0016118 GO:0016119 biolink:BiologicalProcess carotene metabolic process The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids. go.json carotene metabolism http://purl.obolibrary.org/obo/GO_0016119 GO:0016114 biolink:BiologicalProcess terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. Wikipedia:Terpenoid go.json terpenoid anabolism|terpenoid biosynthesis|terpenoid formation|terpenoid synthesis http://purl.obolibrary.org/obo/GO_0016114 GO:0016115 biolink:BiologicalProcess terpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. go.json terpenoid breakdown|terpenoid catabolism|terpenoid degradation http://purl.obolibrary.org/obo/GO_0016115 GO:0016116 biolink:BiologicalProcess carotenoid metabolic process The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. go.json carotenoid metabolism http://purl.obolibrary.org/obo/GO_0016116 GO:0016117 biolink:BiologicalProcess carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. MetaCyc:CAROTENOID-PWY go.json carotenoid anabolism|carotenoid biosynthesis|carotenoid formation|carotenoid synthesis http://purl.obolibrary.org/obo/GO_0016117 GO:0016110 biolink:BiologicalProcess tetraterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units. go.json tetraterpene catabolic process|tetraterpene catabolism|tetraterpenoid breakdown|tetraterpenoid catabolism|tetraterpenoid degradation http://purl.obolibrary.org/obo/GO_0016110 GO:0090055 biolink:BiologicalProcess positive regulation of silent mating-type cassette heterochromatin formation Any process that increases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette. go.json positive regulation of chromatin silencing at silent mating-type cassette|positive regulation of silent mating-type cassette heterochromatin assembly http://purl.obolibrary.org/obo/GO_0090055 GO:0016111 biolink:BiologicalProcess polyterpenoid metabolic process The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units. go.json polyterpene metabolic process|polyterpene metabolism|polyterpenoid metabolism http://purl.obolibrary.org/obo/GO_0016111 GO:0031730 biolink:MolecularActivity CCR5 chemokine receptor binding Binding to a CCR5 chemokine receptor. go.json CCR5 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0031730 GO:0090056 biolink:BiologicalProcess regulation of chlorophyll metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll. go.json http://purl.obolibrary.org/obo/GO_0090056 GO:0016112 biolink:BiologicalProcess polyterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units. go.json polyterpene biosynthesis|polyterpene biosynthetic process|polyterpenoid anabolism|polyterpenoid biosynthesis|polyterpenoid formation|polyterpenoid synthesis http://purl.obolibrary.org/obo/GO_0016112 GO:0090053 biolink:BiologicalProcess positive regulation of pericentric heterochromatin formation Any process that increases the frequency, rate or extent of pericentric heterochromatin formation. go.json positive regulation of chromatin silencing at centromere|positive regulation of pericentric heterochromatin assembly http://purl.obolibrary.org/obo/GO_0090053 GO:0016113 biolink:BiologicalProcess polyterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units. go.json polyterpene catabolic process|polyterpene catabolism|polyterpenoid breakdown|polyterpenoid catabolism|polyterpenoid degradation http://purl.obolibrary.org/obo/GO_0016113 GO:0090054 biolink:BiologicalProcess regulation of silent mating-type cassette heterochromatin formation Any process that modulates the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette. go.json regulation of chromatin silencing at silent mating-type cassette|regulation of silent mating-type cassette heterochromatin assembly http://purl.obolibrary.org/obo/GO_0090054 GO:0090059 biolink:BiologicalProcess protoxylem development The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem. go.json http://purl.obolibrary.org/obo/GO_0090059 GO:0090057 biolink:BiologicalProcess root radial pattern formation The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis. go.json http://purl.obolibrary.org/obo/GO_0090057 GO:0090058 biolink:BiologicalProcess metaxylem development The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. go.json http://purl.obolibrary.org/obo/GO_0090058 GO:0031726 biolink:MolecularActivity CCR1 chemokine receptor binding Binding to a CCR1 chemokine receptor. go.json CCR1 chemokine receptor ligand|macrophage inflammatory protein-1 alpha receptor binding http://purl.obolibrary.org/obo/GO_0031726 GO:0031727 biolink:MolecularActivity CCR2 chemokine receptor binding Binding to a CCR2 chemokine receptor. go.json CCR2 chemokine receptor ligand|monocyte chemoattractant protein 1 receptor binding http://purl.obolibrary.org/obo/GO_0031727 GO:0006768 biolink:BiologicalProcess biotin metabolic process The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. Wikipedia:Biotin go.json biotin metabolism|vitamin B7 metabolic process|vitamin B7 metabolism|vitamin H metabolic process|vitamin H metabolism http://purl.obolibrary.org/obo/GO_0006768 GO:0031724 biolink:MolecularActivity CXCR5 chemokine receptor binding Binding to a CXCR5 chemokine receptor. go.json CXCR5 chemokine receptor ligand|type 1 Burkitt's lymphoma receptor binding http://purl.obolibrary.org/obo/GO_0031724 GO:0006769 biolink:BiologicalProcess nicotinamide metabolic process The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. MetaCyc:PWY-5083 go.json niacin metabolic process|niacin metabolism|nicotinamide metabolism|vitamin B3 metabolic process|vitamin B3 metabolism http://purl.obolibrary.org/obo/GO_0006769 GO:0031725 biolink:MolecularActivity CXCR6 chemokine receptor binding Binding to a CXCR6 chemokine receptor. go.json CXCR6 chemokine receptor ligand|STRL33 receptor binding|bonzo receptor binding http://purl.obolibrary.org/obo/GO_0031725 GO:0006766 biolink:BiologicalProcess vitamin metabolic process The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. go.json vitamin metabolism http://purl.obolibrary.org/obo/GO_0006766 goslim_candida|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast GO:0031722 biolink:MolecularActivity hemoglobin beta binding Binding to a hemoglobin beta chain. go.json http://purl.obolibrary.org/obo/GO_0031722 GO:0031723 biolink:MolecularActivity CXCR4 chemokine receptor binding Binding to a CXCR4 chemokine receptor. go.json CXCR4 chemokine receptor ligand|stromal cell-derived factor 1 receptor binding http://purl.obolibrary.org/obo/GO_0031723 GO:0006767 biolink:BiologicalProcess water-soluble vitamin metabolic process The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. go.json water-soluble vitamin metabolism http://purl.obolibrary.org/obo/GO_0006767 GO:0031720 biolink:MolecularActivity haptoglobin binding Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. go.json http://purl.obolibrary.org/obo/GO_0031720 GO:0006764 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006764 GO:0031721 biolink:MolecularActivity hemoglobin alpha binding Binding to a hemoglobin alpha chain. go.json http://purl.obolibrary.org/obo/GO_0031721 GO:0006765 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006765 GO:0006762 biolink:BiologicalProcess obsolete dihydrofolate reduction OBSOLETE. (Was not defined before being made obsolete). go.json dihydrofolate reduction True http://purl.obolibrary.org/obo/GO_0006762 GO:0006763 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006763 GO:0006760 biolink:BiologicalProcess folic acid-containing compound metabolic process The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. go.json folate and derivative metabolic process|folate and derivative metabolism|folate-containing compound metabolic process|folate-containing compound metabolism|folic acid and derivative metabolic process|folic acid and derivative metabolism|folic acid-containing compound metabolism|vitamin B9 and derivative metabolic process|vitamin B9 and derivative metabolism|vitamin M and derivative metabolic process|vitamin M and derivative metabolism http://purl.obolibrary.org/obo/GO_0006760 GO:0006761 biolink:BiologicalProcess dihydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate. go.json 7,8-dihydrofolate biosynthesis|7,8-dihydrofolate biosynthetic process|dihydrofolate anabolism|dihydrofolate biosynthesis|dihydrofolate formation|dihydrofolate synthesis http://purl.obolibrary.org/obo/GO_0006761 GO:0031728 biolink:MolecularActivity CCR3 chemokine receptor binding Binding to a CCR3 chemokine receptor. go.json CCR3 chemokine receptor ligand|eosinophil eotaxin receptor binding http://purl.obolibrary.org/obo/GO_0031728 GO:0031729 biolink:MolecularActivity CCR4 chemokine receptor binding Binding to a CCR4 chemokine receptor. go.json CCR4 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0031729 GO:0090028 biolink:BiologicalProcess positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0090028 GO:0090029 biolink:BiologicalProcess negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0090029 GO:0090022 biolink:BiologicalProcess regulation of neutrophil chemotaxis Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. go.json http://purl.obolibrary.org/obo/GO_0090022 GO:0090023 biolink:BiologicalProcess positive regulation of neutrophil chemotaxis Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. go.json http://purl.obolibrary.org/obo/GO_0090023 GO:0090020 biolink:BiologicalProcess obsolete regulation of transcription involved in posterior neural plate formation OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate. go.json True http://purl.obolibrary.org/obo/GO_0090020 GO:0090021 biolink:BiologicalProcess positive regulation of posterior neural plate formation by Wnt signaling pathway The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation. go.json positive regulation of posterior neural plate formation by Wnt receptor signaling pathway|positive regulation of posterior neural plate formation by Wnt receptor signalling pathway|positive regulation of posterior neural plate formation by Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0090021 GO:0090026 biolink:BiologicalProcess positive regulation of monocyte chemotaxis Any process that increases the frequency, rate, or extent of monocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_0090026 GO:0090027 biolink:BiologicalProcess negative regulation of monocyte chemotaxis Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_0090027 GO:0090024 biolink:BiologicalProcess negative regulation of neutrophil chemotaxis Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. go.json http://purl.obolibrary.org/obo/GO_0090024 GO:0090025 biolink:BiologicalProcess regulation of monocyte chemotaxis Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_0090025 GO:0031715 biolink:MolecularActivity C5L2 anaphylatoxin chemotactic receptor binding Binding to a C5L2 anaphylatoxin chemotactic receptor. go.json C5L2 anaphylatoxin chemotactic receptor ligand http://purl.obolibrary.org/obo/GO_0031715 GO:0031716 biolink:MolecularActivity calcitonin receptor binding Binding to a calcitonin receptor. go.json calcitonin receptor ligand http://purl.obolibrary.org/obo/GO_0031716 GO:0031713 biolink:MolecularActivity B2 bradykinin receptor binding Binding to a B2 bradykinin receptor. go.json B2 bradykinin receptor ligand http://purl.obolibrary.org/obo/GO_0031713 GO:0006779 biolink:BiologicalProcess porphyrin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. go.json porphyrin anabolism|porphyrin biosynthesis|porphyrin biosynthetic process|porphyrin formation|porphyrin synthesis http://purl.obolibrary.org/obo/GO_0006779 GO:0031714 biolink:MolecularActivity C5a anaphylatoxin chemotactic receptor binding Binding to a C5a anaphylatoxin chemotactic receptor. go.json C5a anaphylatoxin chemotactic receptor ligand http://purl.obolibrary.org/obo/GO_0031714 GO:0031711 biolink:MolecularActivity bradykinin receptor binding Binding to a bradykinin receptor. go.json bradykinin receptor ligand http://purl.obolibrary.org/obo/GO_0031711 GO:0006777 biolink:BiologicalProcess Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. MetaCyc:PWY-6823 go.json Mo-molybdopterin cofactor anabolism|Mo-molybdopterin cofactor biosynthesis|Mo-molybdopterin cofactor formation|Mo-molybdopterin cofactor synthesis|Moco biosynthesis|Moco biosynthetic process|molybdenum cofactor biosynthetic process http://purl.obolibrary.org/obo/GO_0006777 GO:0031712 biolink:MolecularActivity B1 bradykinin receptor binding Binding to a B1 bradykinin receptor. go.json B1 bradykinin receptor ligand http://purl.obolibrary.org/obo/GO_0031712 GO:0090030 biolink:BiologicalProcess regulation of steroid hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. go.json http://purl.obolibrary.org/obo/GO_0090030 GO:0006778 biolink:BiologicalProcess porphyrin-containing compound metabolic process The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. go.json porphyrin metabolic process|porphyrin metabolism http://purl.obolibrary.org/obo/GO_0006778 GO:0006775 biolink:BiologicalProcess fat-soluble vitamin metabolic process The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. go.json fat-soluble vitamin metabolism http://purl.obolibrary.org/obo/GO_0006775 GO:0031710 biolink:MolecularActivity neuromedin B receptor binding Binding to a neuromedin B receptor. go.json neuromedin B receptor ligand http://purl.obolibrary.org/obo/GO_0031710 GO:0006776 biolink:BiologicalProcess vitamin A metabolic process The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene. go.json vitamin A metabolism http://purl.obolibrary.org/obo/GO_0006776 GO:0006773 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006773 GO:0006774 biolink:BiologicalProcess obsolete vitamin B12 reduction OBSOLETE. (Was not defined before being made obsolete). go.json vitamin B12 reduction True http://purl.obolibrary.org/obo/GO_0006774 GO:0006771 biolink:BiologicalProcess riboflavin metabolic process The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Wikipedia:Riboflavin go.json riboflavin metabolism|vitamin B2 metabolic process|vitamin B2 metabolism|vitamin G metabolic process|vitamin G metabolism http://purl.obolibrary.org/obo/GO_0006771 GO:0006772 biolink:BiologicalProcess thiamine metabolic process The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. Wikipedia:Thiamine go.json thiamin metabolic process|thiamin metabolism|thiamine metabolism|vitamin B1 metabolic process|vitamin B1 metabolism http://purl.obolibrary.org/obo/GO_0006772 GO:0031719 biolink:MolecularActivity type 2 cannabinoid receptor binding Binding to a type 2 cannabinoid receptor. go.json type 2 cannabinoid receptor ligand http://purl.obolibrary.org/obo/GO_0031719 GO:0006770 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006770 GO:0031717 biolink:MolecularActivity cannabinoid receptor binding Binding to a cannabinoid receptor. go.json cannabinoid receptor ligand http://purl.obolibrary.org/obo/GO_0031717 GO:0031718 biolink:MolecularActivity type 1 cannabinoid receptor binding Binding to a type 1 cannabinoid receptor. go.json type 1 cannabinoid receptor ligand http://purl.obolibrary.org/obo/GO_0031718 GO:0090039 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090039 GO:0090033 biolink:BiologicalProcess positive regulation of filamentous growth Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0090033 GO:0090034 biolink:BiologicalProcess regulation of chaperone-mediated protein complex assembly Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. go.json http://purl.obolibrary.org/obo/GO_0090034 GO:0090031 biolink:BiologicalProcess positive regulation of steroid hormone biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. go.json http://purl.obolibrary.org/obo/GO_0090031 GO:0090032 biolink:BiologicalProcess negative regulation of steroid hormone biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. go.json http://purl.obolibrary.org/obo/GO_0090032 GO:0090037 biolink:BiologicalProcess positive regulation of protein kinase C signaling Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. go.json positive regulation of protein kinase C signaling cascade|positive regulation of protein kinase C signalling cascade http://purl.obolibrary.org/obo/GO_0090037 GO:0090038 biolink:BiologicalProcess negative regulation of protein kinase C signaling Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. go.json negative regulation of protein kinase C signaling cascade|negative regulation of protein kinase C signalling cascade http://purl.obolibrary.org/obo/GO_0090038 GO:0090035 biolink:BiologicalProcess positive regulation of chaperone-mediated protein complex assembly Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. go.json http://purl.obolibrary.org/obo/GO_0090035 GO:0090036 biolink:BiologicalProcess regulation of protein kinase C signaling Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. go.json regulation of protein kinase C signaling cascade|regulation of protein kinase C signalling cascade http://purl.obolibrary.org/obo/GO_0090036 GO:0031704 biolink:MolecularActivity apelin receptor binding Binding to an apelin receptor. go.json APJ receptor binding|apelin receptor ligand http://purl.obolibrary.org/obo/GO_0031704 GO:0090080 biolink:BiologicalProcess positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade. go.json positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0090080 GO:0006748 biolink:BiologicalProcess lipoamide metabolic process The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. go.json lipoamide metabolism http://purl.obolibrary.org/obo/GO_0006748 GO:0090081 biolink:BiologicalProcess regulation of heart induction by regulation of canonical Wnt signaling pathway Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of heart induction by regulation of canonical Wnt receptor signalling pathway|regulation of heart induction by regulation of canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0090081 GO:0031705 biolink:MolecularActivity bombesin receptor binding Binding to a bombesin receptor. go.json bombesin receptor ligand http://purl.obolibrary.org/obo/GO_0031705 GO:0006749 biolink:BiologicalProcess glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. go.json glutathione metabolism|oxidized glutathione reduction http://purl.obolibrary.org/obo/GO_0006749 GO:0006746 biolink:BiologicalProcess FADH2 metabolic process The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide. go.json FADH2 metabolism|reduced flavin adenine dinucleotide metabolic process http://purl.obolibrary.org/obo/GO_0006746 GO:0031702 biolink:MolecularActivity type 1 angiotensin receptor binding Binding to a type 1 angiotensin receptor. go.json AT1 receptor binding|type 1 angiotensin receptor ligand http://purl.obolibrary.org/obo/GO_0031702 GO:0031703 biolink:MolecularActivity type 2 angiotensin receptor binding Binding to a type 2 angiotensin receptor. go.json AT2 receptor binding|type 2 angiotensin receptor ligand http://purl.obolibrary.org/obo/GO_0031703 GO:0006747 biolink:BiologicalProcess FAD biosynthetic process The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide. go.json FAD anabolism|FAD biosynthesis|FAD formation|FAD synthesis|oxidized flavin adenine dinucleotide biosynthesis|oxidized flavin adenine dinucleotide biosynthetic process|oxidized flavin-adenine dinucleotide biosynthesis|oxidized flavin-adenine dinucleotide biosynthetic process http://purl.obolibrary.org/obo/GO_0006747 GO:0006744 biolink:BiologicalProcess ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. MetaCyc:UBISYN-PWY go.json coenzyme Q biosynthesis|coenzyme Q biosynthetic process|coenzyme Q10 biosynthesis|coenzyme Q10 biosynthetic process|coenzyme Q6 biosynthesis|coenzyme Q6 biosynthetic process|coenzyme Q8 biosynthesis|coenzyme Q8 biosynthetic process|coenzyme Q9 biosynthesis|coenzyme Q9 biosynthetic process|ubiquinone anabolism|ubiquinone biosynthesis|ubiquinone formation|ubiquinone synthesis http://purl.obolibrary.org/obo/GO_0006744 goslim_drosophila|goslim_pombe GO:0090084 biolink:BiologicalProcess negative regulation of inclusion body assembly Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. go.json http://purl.obolibrary.org/obo/GO_0090084 GO:0031700 biolink:MolecularActivity adrenomedullin receptor binding Binding to an adrenomedullin receptor. go.json adrenomedullin receptor ligand http://purl.obolibrary.org/obo/GO_0031700 GO:0006745 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006745 GO:0090085 biolink:BiologicalProcess regulation of protein deubiquitination Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. go.json http://purl.obolibrary.org/obo/GO_0090085 GO:0031701 biolink:MolecularActivity angiotensin receptor binding Binding to an angiotensin receptor. go.json angiotensin receptor ligand http://purl.obolibrary.org/obo/GO_0031701 GO:0006742 biolink:BiologicalProcess NADP catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. go.json NADP (oxidized) catabolic process|NADP (oxidized) catabolism|NADP (reduced) catabolic process|NADP (reduced) catabolism|NADP breakdown|NADP catabolism|NADP degradation|NADPH catabolic process|NADPH catabolism|nicotinamide adenine dinucleotide phosphate catabolic process|nicotinamide adenine dinucleotide phosphate catabolism|oxidized NADP catabolic process|oxidized NADP catabolism|oxidized nicotinamide adenine dinucleotide phosphate catabolic process|oxidized nicotinamide adenine dinucleotide phosphate catabolism|reduced NADP catabolic process|reduced NADP catabolism|reduced nicotinamide adenine dinucleotide phosphate catabolic process|reduced nicotinamide adenine dinucleotide phosphate catabolism http://purl.obolibrary.org/obo/GO_0006742 GO:0090082 biolink:BiologicalProcess positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway|positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0090082 GO:0090083 biolink:BiologicalProcess regulation of inclusion body assembly Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. go.json http://purl.obolibrary.org/obo/GO_0090083 GO:0006743 biolink:BiologicalProcess ubiquinone metabolic process The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. go.json coenzyme Q metabolic process|coenzyme Q metabolism|ubiquinone metabolism http://purl.obolibrary.org/obo/GO_0006743 GO:0006740 biolink:BiologicalProcess NADPH regeneration A metabolic process that generates a pool of NADPH by the reduction of NADP+. go.json NADP (reduced) regeneration|reduced NADP regeneration|reduced nicotinamide adenine dinucleotide phosphate regeneration http://purl.obolibrary.org/obo/GO_0006740 GO:0006741 biolink:BiologicalProcess NADP biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. go.json NADP (oxidized) biosynthesis|NADP (oxidized) biosynthetic process|NADP (reduced) biosynthesis|NADP (reduced) biosynthetic process|NADP anabolism|NADP biosynthesis|NADP formation|NADP synthesis|NADPH biosynthesis|NADPH biosynthetic process|nicotinamide adenine dinucleotide phosphate biosynthesis|nicotinamide adenine dinucleotide phosphate biosynthetic process|oxidized NADP biosynthesis|oxidized NADP biosynthetic process|oxidized nicotinamide adenine dinucleotide phosphate biosynthesis|oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process|reduced NADP biosynthesis|reduced NADP biosynthetic process|reduced nicotinamide adenine dinucleotide phosphate biosynthesis|reduced nicotinamide adenine dinucleotide phosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0006741 GO:0031708 biolink:MolecularActivity endothelin B receptor binding Binding to an endothelin B receptor. go.json endothelin B receptor ligand http://purl.obolibrary.org/obo/GO_0031708 GO:0031709 biolink:MolecularActivity gastrin-releasing peptide receptor binding Binding to a gastrin-releasing peptide receptor. go.json GRP receptor binding|gastrin-releasing peptide receptor ligand http://purl.obolibrary.org/obo/GO_0031709 GO:0031706 biolink:MolecularActivity subtype 3 bombesin receptor binding Binding to a subtype 3 bombesin receptor. go.json subtype 3 bombesin receptor ligand http://purl.obolibrary.org/obo/GO_0031706 GO:0031707 biolink:MolecularActivity endothelin A receptor binding Binding to an endothelin A receptor. go.json endothelin A receptor ligand|endothelin-1 receptor binding http://purl.obolibrary.org/obo/GO_0031707 GO:0090088 biolink:BiologicalProcess regulation of oligopeptide transport Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. go.json http://purl.obolibrary.org/obo/GO_0090088 GO:0090089 biolink:BiologicalProcess regulation of dipeptide transport Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0090089 GO:0090086 biolink:BiologicalProcess negative regulation of protein deubiquitination Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. go.json http://purl.obolibrary.org/obo/GO_0090086 GO:0090087 biolink:BiologicalProcess regulation of peptide transport Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0090087 GO:0090091 biolink:BiologicalProcess positive regulation of extracellular matrix disassembly Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0090091 GO:0006759 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006759 GO:0090092 biolink:BiologicalProcess regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. go.json regulation of transmembrane receptor protein serine/threonine kinase signalling pathway http://purl.obolibrary.org/obo/GO_0090092 GO:0006757 biolink:BiologicalProcess obsolete ATP generation from ADP OBSOLETE. The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. go.json ADP phosphorylation True http://purl.obolibrary.org/obo/GO_0006757 GO:0090090 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json negative regulation of Wnt receptor signaling pathway through beta-catenin|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of canonical Wnt receptor signalling pathway|negative regulation of canonical Wnt-activated signaling pathway|negative regulation of catenin import into nucleus|negative regulation of catenin protein nuclear translocation http://purl.obolibrary.org/obo/GO_0090090 GO:0006758 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006758 GO:0090095 biolink:BiologicalProcess regulation of metanephric cap mesenchymal cell proliferation Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. go.json http://purl.obolibrary.org/obo/GO_0090095 GO:0006755 biolink:BiologicalProcess obsolete carbamoyl phosphate-ADP transphosphorylation OBSOLETE. (Was not defined before being made obsolete). go.json carbamoyl phosphate-ADP transphosphorylation True http://purl.obolibrary.org/obo/GO_0006755 GO:0090096 biolink:BiologicalProcess positive regulation of metanephric cap mesenchymal cell proliferation Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. go.json http://purl.obolibrary.org/obo/GO_0090096 GO:0006756 biolink:BiologicalProcess AMP phosphorylation The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP. go.json http://purl.obolibrary.org/obo/GO_0006756 GO:0090093 biolink:BiologicalProcess regulation of fungal-type cell wall beta-glucan biosynthetic process Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. go.json http://purl.obolibrary.org/obo/GO_0090093 GO:0006753 biolink:BiologicalProcess nucleoside phosphate metabolic process The chemical reactions and pathways involving any phosphorylated nucleoside. go.json nucleoside phosphate metabolism http://purl.obolibrary.org/obo/GO_0006753 GO:0006754 biolink:BiologicalProcess ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. go.json ATP anabolism|ATP biosynthesis|ATP formation|ATP regeneration|ATP synthesis http://purl.obolibrary.org/obo/GO_0006754 GO:0090094 biolink:BiologicalProcess metanephric cap mesenchymal cell proliferation involved in metanephros development The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. go.json http://purl.obolibrary.org/obo/GO_0090094 GO:0006751 biolink:BiologicalProcess glutathione catabolic process The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. go.json glutathione breakdown|glutathione catabolism|glutathione degradation http://purl.obolibrary.org/obo/GO_0006751 GO:0006752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006752 GO:0006750 biolink:BiologicalProcess glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. MetaCyc:GLUTATHIONESYN-PWY go.json glutathione anabolism|glutathione biosynthesis|glutathione formation|glutathione synthesis http://purl.obolibrary.org/obo/GO_0006750 GO:0090099 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090099 GO:0090097 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090097 GO:0090098 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090098 GO:0006726 biolink:BiologicalProcess eye pigment biosynthetic process The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. go.json eye pigment anabolism|eye pigment biosynthesis|eye pigment formation|eye pigment synthesis http://purl.obolibrary.org/obo/GO_0006726 GO:0006727 biolink:BiologicalProcess ommochrome biosynthetic process The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. go.json ommochrome anabolism|ommochrome biosynthesis|ommochrome formation|ommochrome synthesis http://purl.obolibrary.org/obo/GO_0006727 GO:0006724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006724 GO:0006725 biolink:BiologicalProcess cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. go.json aromatic compound metabolism|aromatic hydrocarbon metabolic process|aromatic hydrocarbon metabolism http://purl.obolibrary.org/obo/GO_0006725 goslim_pir GO:0006722 biolink:BiologicalProcess triterpenoid metabolic process The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units. go.json triterpene metabolic process|triterpene metabolism|triterpenoid metabolism http://purl.obolibrary.org/obo/GO_0006722 GO:0090062 biolink:BiologicalProcess regulation of trehalose metabolic process Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. go.json http://purl.obolibrary.org/obo/GO_0090062 GO:0090063 biolink:BiologicalProcess positive regulation of microtubule nucleation Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. go.json http://purl.obolibrary.org/obo/GO_0090063 GO:0006723 biolink:BiologicalProcess cuticle hydrocarbon biosynthetic process The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss. go.json cuticle hydrocarbon anabolism|cuticle hydrocarbon biosynthesis|cuticle hydrocarbon formation|cuticle hydrocarbon synthesis http://purl.obolibrary.org/obo/GO_0006723 GO:0006720 biolink:BiologicalProcess isoprenoid metabolic process The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. go.json isoprenoid metabolism|polyisoprenoid metabolic process|polyisoprenoid metabolism|polyterpene metabolic process|polyterpene metabolism http://purl.obolibrary.org/obo/GO_0006720 GO:0090060 biolink:BiologicalProcess regulation of metaxylem development Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. go.json http://purl.obolibrary.org/obo/GO_0090060 GO:0090061 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090061 GO:0006721 biolink:BiologicalProcess terpenoid metabolic process The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. go.json terpenoid metabolism http://purl.obolibrary.org/obo/GO_0006721 GO:0090066 biolink:BiologicalProcess regulation of anatomical structure size Any process that modulates the size of an anatomical structure. go.json http://purl.obolibrary.org/obo/GO_0090066 GO:0090067 biolink:BiologicalProcess regulation of thalamus size Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus. go.json http://purl.obolibrary.org/obo/GO_0090067 GO:0090064 biolink:BiologicalProcess activation of microtubule nucleation Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. go.json http://purl.obolibrary.org/obo/GO_0090064 GO:0090065 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090065 GO:0006728 biolink:BiologicalProcess pteridine biosynthetic process The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. go.json pteridine anabolism|pteridine biosynthesis|pteridine formation|pteridine synthesis|pterin biosynthesis|pterin biosynthetic process http://purl.obolibrary.org/obo/GO_0006728 GO:0090068 biolink:BiologicalProcess positive regulation of cell cycle process Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. go.json http://purl.obolibrary.org/obo/GO_0090068 GO:0090069 biolink:BiologicalProcess regulation of ribosome biogenesis Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. go.json http://purl.obolibrary.org/obo/GO_0090069 GO:0006729 biolink:BiologicalProcess tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. go.json 5,6,7,8-tetrahydrobiopterin biosynthetic process|tetrahydrobiopterin anabolism|tetrahydrobiopterin biosynthesis|tetrahydrobiopterin formation|tetrahydrobiopterin synthesis http://purl.obolibrary.org/obo/GO_0006729 GO:0006737 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006737 GO:0090070 biolink:BiologicalProcess positive regulation of ribosome biogenesis Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. go.json http://purl.obolibrary.org/obo/GO_0090070 GO:0006738 biolink:BiologicalProcess nicotinamide riboside catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. go.json N-ribosylnicotinamide catabolic process|nicotinamide riboside breakdown|nicotinamide riboside catabolism|nicotinamide riboside degradation http://purl.obolibrary.org/obo/GO_0006738 GO:0006735 biolink:BiologicalProcess NADH regeneration A metabolic process that generates a pool of NADH by the reduction of NAD+. go.json NAD (reduced) regeneration|reduced NAD regeneration|reduced nicotinamide adenine dinucleotide regeneration http://purl.obolibrary.org/obo/GO_0006735 GO:0006736 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006736 GO:0006733 biolink:BiologicalProcess obsolete oxidoreduction coenzyme metabolic process OBSOLETE. The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. go.json oxidoreduction coenzyme metabolism True http://purl.obolibrary.org/obo/GO_0006733 GO:0090073 biolink:BiologicalProcess positive regulation of protein homodimerization activity Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. go.json http://purl.obolibrary.org/obo/GO_0090073 gocheck_do_not_annotate GO:0006734 biolink:BiologicalProcess NADH metabolic process The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. go.json NAD (reduced) metabolic process|NAD (reduced) metabolism|NADH metabolism|reduced NAD metabolic process|reduced NAD metabolism|reduced nicotinamide adenine dinucleotide metabolic process|reduced nicotinamide adenine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_0006734 GO:0090074 biolink:BiologicalProcess negative regulation of protein homodimerization activity Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. go.json http://purl.obolibrary.org/obo/GO_0090074 gocheck_do_not_annotate GO:0006731 biolink:BiologicalProcess obsolete coenzyme and prosthetic group metabolic process OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups. go.json coenzyme and prosthetic group metabolic process True http://purl.obolibrary.org/obo/GO_0006731 GO:0090071 biolink:BiologicalProcess negative regulation of ribosome biogenesis Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. go.json http://purl.obolibrary.org/obo/GO_0090071 GO:0006732 biolink:BiologicalProcess obsolete coenzyme metabolic process OBSOLETE. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. go.json coenzyme and prosthetic group metabolic process|coenzyme and prosthetic group metabolism|coenzyme metabolism|group transfer coenzyme metabolic process|group transfer coenzyme metabolism True http://purl.obolibrary.org/obo/GO_0006732 GO:0090072 biolink:BiologicalProcess obsolete positive regulation of sodium ion transport via voltage-gated sodium channel activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels. go.json positive regulation of sodium ion transport via voltage-gated sodium channel activity True http://purl.obolibrary.org/obo/GO_0090072 GO:0006730 biolink:BiologicalProcess one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. UM-BBD_pathwayID:C1cyc go.json one carbon metabolic process|one carbon metabolism|one-carbon metabolism|one-carbon transfer metabolic process|one-carbon transfer metabolism http://purl.obolibrary.org/obo/GO_0006730 goslim_pir GO:0090077 biolink:BiologicalProcess foam cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. go.json http://purl.obolibrary.org/obo/GO_0090077 GO:0090078 biolink:BiologicalProcess smooth muscle derived foam cell differentiation The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. go.json http://purl.obolibrary.org/obo/GO_0090078 GO:0090075 biolink:BiologicalProcess relaxation of muscle A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. go.json http://purl.obolibrary.org/obo/GO_0090075 GO:0090076 biolink:BiologicalProcess relaxation of skeletal muscle A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. go.json http://purl.obolibrary.org/obo/GO_0090076 GO:0006739 biolink:BiologicalProcess NADP metabolic process The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. go.json NAD phosphorylation and dephosphorylation|NADP (oxidized) metabolic process|NADP (oxidized) metabolism|NADP (reduced) metabolic process|NADP (reduced) metabolism|NADP metabolism|NADPH metabolic process|NADPH metabolism|nicotinamide adenine dinucleotide phosphate metabolic process|nicotinamide adenine dinucleotide phosphate metabolism|oxidized NADP metabolic process|oxidized NADP metabolism|oxidized nicotinamide adenine dinucleotide phosphate metabolic process|oxidized nicotinamide adenine dinucleotide phosphate metabolism|reduced NADP metabolic process|reduced NADP metabolism|reduced nicotinamide adenine dinucleotide phosphate metabolic process|reduced nicotinamide adenine dinucleotide phosphate metabolism http://purl.obolibrary.org/obo/GO_0006739 GO:0090079 biolink:MolecularActivity translation regulator activity, nucleic acid binding Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. go.json http://purl.obolibrary.org/obo/GO_0090079 GO:0090206 biolink:BiologicalProcess negative regulation of cholesterol metabolic process Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json http://purl.obolibrary.org/obo/GO_0090206 GO:0090207 biolink:BiologicalProcess regulation of triglyceride metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. go.json http://purl.obolibrary.org/obo/GO_0090207 GO:0090204 biolink:BiologicalProcess protein localization to nuclear pore A process in which a protein is transported to, or maintained in, a nuclear pore. go.json protein localisation to nuclear pore http://purl.obolibrary.org/obo/GO_0090204 GO:0090205 biolink:BiologicalProcess positive regulation of cholesterol metabolic process Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json http://purl.obolibrary.org/obo/GO_0090205 GO:0090208 biolink:BiologicalProcess positive regulation of triglyceride metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. go.json http://purl.obolibrary.org/obo/GO_0090208 GO:0090209 biolink:BiologicalProcess negative regulation of triglyceride metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. go.json http://purl.obolibrary.org/obo/GO_0090209 GO:0090202 biolink:BiologicalProcess obsolete gene looping OBSOLETE. The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes. go.json True http://purl.obolibrary.org/obo/GO_0090202 GO:0090203 biolink:BiologicalProcess obsolete transcriptional activation by promoter-terminator looping OBSOLETE. The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter. go.json transcriptional activation by memory gene loops True http://purl.obolibrary.org/obo/GO_0090203 GO:0090200 biolink:BiologicalProcess positive regulation of release of cytochrome c from mitochondria Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. go.json http://purl.obolibrary.org/obo/GO_0090200 GO:0090201 biolink:BiologicalProcess negative regulation of release of cytochrome c from mitochondria Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. go.json http://purl.obolibrary.org/obo/GO_0090201 GO:0090217 biolink:BiologicalProcess obsolete negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity OBSOLETE. Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. go.json True http://purl.obolibrary.org/obo/GO_0090217 GO:0090218 biolink:BiologicalProcess positive regulation of lipid kinase activity Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. go.json http://purl.obolibrary.org/obo/GO_0090218 gocheck_do_not_annotate GO:0090215 biolink:BiologicalProcess obsolete regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity OBSOLETE. Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. go.json True http://purl.obolibrary.org/obo/GO_0090215 GO:0090216 biolink:BiologicalProcess obsolete positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity OBSOLETE. Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. go.json True http://purl.obolibrary.org/obo/GO_0090216 GO:0090219 biolink:BiologicalProcess negative regulation of lipid kinase activity Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. go.json http://purl.obolibrary.org/obo/GO_0090219 gocheck_do_not_annotate GO:0090210 biolink:BiologicalProcess regulation of establishment of blood-brain barrier Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. go.json regulation of establishment of BBB http://purl.obolibrary.org/obo/GO_0090210 GO:0090213 biolink:BiologicalProcess regulation of radial pattern formation Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur. go.json regulation of radial pattern specification http://purl.obolibrary.org/obo/GO_0090213 GO:0090214 biolink:BiologicalProcess spongiotrophoblast layer developmental growth The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0090214 GO:0090211 biolink:BiologicalProcess positive regulation of establishment of blood-brain barrier Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. go.json positive regulation of establishment of BBB http://purl.obolibrary.org/obo/GO_0090211 GO:0090212 biolink:BiologicalProcess negative regulation of establishment of blood-brain barrier Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. go.json negative regulation of establishment of BBB http://purl.obolibrary.org/obo/GO_0090212 GO:0016290 biolink:MolecularActivity palmitoyl-CoA hydrolase activity Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. EC:3.1.2.2|MetaCyc:PALMITOYL-COA-HYDROLASE-RXN|MetaCyc:PWY-5148|RHEA:16645 go.json fatty acyl thioesterase I|long-chain fatty-acyl-CoA hydrolase activity|palmitoyl coenzyme A hydrolase activity|palmitoyl thioesterase activity|palmitoyl-CoA deacylase activity|palmityl thioesterase I|palmityl thioesterase activity|palmityl-CoA deacylase activity http://purl.obolibrary.org/obo/GO_0016290 goslim_chembl GO:0016291 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016291 GO:0016292 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016292 GO:0016286 biolink:MolecularActivity small conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. go.json SK KCa channels|SK calcium-activated potassium channel activity|small conductance KCa channels http://purl.obolibrary.org/obo/GO_0016286 GO:0016287 biolink:MolecularActivity glycerone-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. EC:2.3.1.42|KEGG_REACTION:R01013|MetaCyc:2.3.1.42-RXN|RHEA:17657|Reactome:R-HSA-1483002|Reactome:R-HSA-75879 go.json acyl-CoA:glycerone-phosphate O-acyltransferase activity|dihydroxyacetone phosphate acyltransferase activity http://purl.obolibrary.org/obo/GO_0016287 GO:0016288 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016288 GO:0016289 biolink:MolecularActivity CoA hydrolase activity Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. Reactome:R-HSA-193385 go.json http://purl.obolibrary.org/obo/GO_0016289 GO:0016282 biolink:CellularComponent eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA. go.json eukaryotic 43S pre-initiation complex http://purl.obolibrary.org/obo/GO_0016282 GO:0016283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016283 GO:0016284 biolink:MolecularActivity obsolete alanine aminopeptidase activity OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide. EC:3.4.11.- go.json alanine aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0016284 GO:0016285 biolink:MolecularActivity obsolete cytosol alanyl aminopeptidase activity OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides. EC:3.4.11.14|MetaCyc:3.4.11.14-RXN go.json aminopolypeptidase activity|arylamidase activity|cytosol alanyl aminopeptidase activity|cytosol aminopeptidase III activity|human liver aminopeptidase|liver aminopeptidase activity|puromycin-sensitive aminopeptidase activity|soluble alanyl aminopeptidase activity|thiol-activated aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0016285 GO:0016297 biolink:MolecularActivity acyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid. EC:3.1.2.14|MetaCyc:RXN-7902|Reactome:R-HSA-5655955 go.json acyl-ACP hydrolase activity|acyl-ACP thioesterase activity|acyl-ACP-hydrolase activity|acyl-[acyl-carrier protein] hydrolase activity|acyl-acyl carrier protein hydrolase activity|acyl-acyl-carrier-protein hydrolase activity http://purl.obolibrary.org/obo/GO_0016297 GO:0016298 biolink:MolecularActivity lipase activity Catalysis of the hydrolysis of a lipid or phospholipid. Reactome:R-HSA-163402|Reactome:R-HSA-163432 go.json http://purl.obolibrary.org/obo/GO_0016298 goslim_chembl|goslim_drosophila GO:0016299 biolink:MolecularActivity obsolete regulator of G-protein signaling activity OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. go.json RGS|regulator of G protein signaling activity|regulator of G protein signalling activity|regulator of G-protein signaling activity|regulator of G-protein signalling activity True http://purl.obolibrary.org/obo/GO_0016299 GO:0016293 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016293 GO:0016294 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016294 GO:0016295 biolink:MolecularActivity myristoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H+. KEGG_REACTION:R08159|MetaCyc:RXN-10727|RHEA:30123 go.json myristoyl-ACP hydrolase activity|myristoyl-[acyl-carrier protein] hydrolase activity|tetradecanoyl-ACP hydrolase activity|tetradecanoyl-[acyl-carrier-protein] hydrolase activity http://purl.obolibrary.org/obo/GO_0016295 GO:0016296 biolink:MolecularActivity palmitoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: hexadecanoyl-[ACP] + H2O = H+ + hexadecanoate + holo-[ACP]. KEGG_REACTION:R08162|MetaCyc:RXN-9549|RHEA:41932 go.json palmitoyl-ACP hydrolase activity|palmitoyl-[acyl-carrier protein] hydrolase activity http://purl.obolibrary.org/obo/GO_0016296 GO:0016270 biolink:BiologicalProcess O-glycan processing, core 4 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0016270 gocheck_do_not_annotate GO:0090248 biolink:BiologicalProcess cell migration involved in somitogenic axis elongation Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation. go.json cell motility involved in somitogenic axis elongation http://purl.obolibrary.org/obo/GO_0090248 GO:0090249 biolink:BiologicalProcess regulation of cell migration involved in somitogenic axis elongation Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation. go.json regulation of cell motility involved in somitogenic axis elongation http://purl.obolibrary.org/obo/GO_0090249 GO:0016268 biolink:BiologicalProcess O-glycan processing, core 2 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0016268 gocheck_do_not_annotate GO:0016269 biolink:BiologicalProcess O-glycan processing, core 3 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0016269 gocheck_do_not_annotate GO:0016264 biolink:BiologicalProcess gap junction assembly Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids. go.json http://purl.obolibrary.org/obo/GO_0016264 GO:0090242 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in somitogenesis The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis. go.json retinoic acid receptor signalling pathway involved in somitogenesis http://purl.obolibrary.org/obo/GO_0090242 GO:0016265 biolink:BiologicalProcess obsolete death OBSOLETE. A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. Wikipedia:Death go.json True http://purl.obolibrary.org/obo/GO_0016265 GO:0090243 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in somitogenesis The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis. go.json fibroblast growth factor receptor signalling pathway involved in somitogenesis http://purl.obolibrary.org/obo/GO_0090243 GO:0016266 biolink:BiologicalProcess O-glycan processing The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. go.json http://purl.obolibrary.org/obo/GO_0016266 GO:0090240 biolink:BiologicalProcess positive regulation of histone H4 acetylation Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0090240 GO:0090241 biolink:BiologicalProcess negative regulation of histone H4 acetylation Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0090241 GO:0016267 biolink:BiologicalProcess O-glycan processing, core 1 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0016267 gocheck_do_not_annotate GO:0090246 biolink:BiologicalProcess convergent extension involved in somitogenesis The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis. go.json http://purl.obolibrary.org/obo/GO_0090246 GO:0016260 biolink:BiologicalProcess selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins. go.json selenocysteine anabolism|selenocysteine biosynthesis|selenocysteine formation|selenocysteine synthesis http://purl.obolibrary.org/obo/GO_0016260 GO:0090247 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090247 GO:0016261 biolink:BiologicalProcess selenocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins. go.json selenocysteine breakdown|selenocysteine catabolism|selenocysteine degradation http://purl.obolibrary.org/obo/GO_0016261 GO:0016262 biolink:MolecularActivity protein N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. EC:2.4.1.94|MetaCyc:2.4.1.94-RXN|RHEA:16533 go.json N-GlcNAc transferase activity|UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity|UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity|protein N-GlcNAc transferase activity|uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0016262 GO:0090244 biolink:BiologicalProcess Wnt signaling pathway involved in somitogenesis The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis. go.json Wnt receptor signaling pathway involved in somitogenesis|Wnt receptor signalling|Wnt-activated signaling pathway involved in somitogenesis http://purl.obolibrary.org/obo/GO_0090244 GO:0090245 biolink:BiologicalProcess axis elongation involved in somitogenesis The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis. go.json http://purl.obolibrary.org/obo/GO_0090245 GO:0016263 biolink:MolecularActivity glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan. EC:2.4.1.122|MetaCyc:2.4.1.122-RXN|RHEA:15621|Reactome:R-HSA-1964505|Reactome:R-HSA-6785524 go.json Core 1 GalT|UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity|UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity|uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0016263 GO:0016280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016280 GO:0016281 biolink:CellularComponent eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. go.json cytoplasmic cap-binding complex|eIF-4F|eukaryotic translation initiation factor 4 complex http://purl.obolibrary.org/obo/GO_0016281 GO:0031898 biolink:CellularComponent chromoplast envelope The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0031898 GO:0090250 biolink:BiologicalProcess cell-cell adhesion involved in establishment of planar polarity The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity. go.json http://purl.obolibrary.org/obo/GO_0090250 GO:0031899 biolink:CellularComponent chromoplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma. go.json http://purl.obolibrary.org/obo/GO_0031899 GO:0031896 biolink:MolecularActivity V2 vasopressin receptor binding Binding to a V2 vasopressin receptor. go.json V2 vasopressin receptor ligand http://purl.obolibrary.org/obo/GO_0031896 GO:0031897 biolink:CellularComponent Tic complex The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane. go.json chloroplast inner membrane translocase complex http://purl.obolibrary.org/obo/GO_0031897 GO:0090259 biolink:BiologicalProcess regulation of retinal ganglion cell axon guidance Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. go.json http://purl.obolibrary.org/obo/GO_0090259 GO:0016279 biolink:MolecularActivity protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. RHEA:51736|Reactome:R-HSA-212263|Reactome:R-HSA-8865237|Reactome:R-HSA-8931858|Reactome:R-HSA-8931974|Reactome:R-HSA-8932221|Reactome:R-HSA-8932243|Reactome:R-HSA-8932275|Reactome:R-HSA-8932276|Reactome:R-HSA-8932413 go.json protein (lysine) methyltransferase activity|protein lysine methylase activity http://purl.obolibrary.org/obo/GO_0016279 GO:0031894 biolink:MolecularActivity V1A vasopressin receptor binding Binding to a V1A vasopressin receptor. go.json V1A vasopressin receptor ligand http://purl.obolibrary.org/obo/GO_0031894 GO:0090253 biolink:BiologicalProcess convergent extension involved in imaginal disc-derived wing morphogenesis The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0090253 GO:0016275 biolink:MolecularActivity obsolete [cytochrome c]-arginine N-methyltransferase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine. go.json S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea|S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea|cytochrome c-arginine N-methyltransferase activity True http://purl.obolibrary.org/obo/GO_0016275 GO:0016276 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016276 GO:0031895 biolink:MolecularActivity V1B vasopressin receptor binding Binding to a V1B vasopressin receptor. go.json V1B vasopressin receptor ligand http://purl.obolibrary.org/obo/GO_0031895 GO:0090254 biolink:BiologicalProcess cell elongation involved in imaginal disc-derived wing morphogenesis The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0090254 GO:0090251 biolink:BiologicalProcess protein localization involved in establishment of planar polarity Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity. go.json protein localisation involved in establishment of planar polarity http://purl.obolibrary.org/obo/GO_0090251 GO:0031892 biolink:MolecularActivity type 2 vasoactive intestinal polypeptide receptor binding Binding to a type 2 vasoactive intestinal polypeptide receptor. go.json type 2 vasoactive intestinal polypeptide receptor ligand|type 3 PACAP receptor binding http://purl.obolibrary.org/obo/GO_0031892 GO:0016277 biolink:MolecularActivity obsolete [myelin basic protein]-arginine N-methyltransferase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine. go.json True http://purl.obolibrary.org/obo/GO_0016277 GO:0031893 biolink:MolecularActivity vasopressin receptor binding Binding to a vasopressin receptor. go.json vasopressin receptor ligand http://purl.obolibrary.org/obo/GO_0031893 GO:0090252 biolink:BiologicalProcess epithelium migration involved in imaginal disc-derived wing morphogenesis The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0090252 GO:0016278 biolink:MolecularActivity lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. Reactome:R-HSA-3222237|Reactome:R-HSA-6805730|Reactome:R-HSA-6805740|Reactome:R-HSA-6805755 go.json http://purl.obolibrary.org/obo/GO_0016278 GO:0031890 biolink:MolecularActivity vasoactive intestinal polypeptide receptor binding Binding to a vasoactive intestinal polypeptide receptor. go.json VIP receptor binding|vasoactive intestinal polypeptide receptor ligand http://purl.obolibrary.org/obo/GO_0031890 GO:0090257 biolink:BiologicalProcess regulation of muscle system process Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. go.json http://purl.obolibrary.org/obo/GO_0090257 GO:0016271 biolink:BiologicalProcess obsolete tissue death OBSOLETE. A permanent cessation of all vital functions of a tissue. go.json True http://purl.obolibrary.org/obo/GO_0016271 GO:0031891 biolink:MolecularActivity type 1 vasoactive intestinal polypeptide receptor binding Binding to a type 1 vasoactive intestinal polypeptide receptor. go.json type 1 vasoactive intestinal polypeptide receptor ligand|type 2 PACAP receptor binding http://purl.obolibrary.org/obo/GO_0031891 GO:0016272 biolink:CellularComponent prefoldin complex A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. Wikipedia:Prefoldin go.json GIM complex http://purl.obolibrary.org/obo/GO_0016272 GO:0090258 biolink:BiologicalProcess negative regulation of mitochondrial fission Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. go.json negative regulation of mitochondrial division http://purl.obolibrary.org/obo/GO_0090258 GO:0090255 biolink:BiologicalProcess cell proliferation involved in imaginal disc-derived wing morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0090255 GO:0016273 biolink:MolecularActivity arginine N-methyltransferase activity Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. go.json http://purl.obolibrary.org/obo/GO_0016273 GO:0016274 biolink:MolecularActivity protein-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. Reactome:R-HSA-191790|Reactome:R-HSA-5205798|Reactome:R-HSA-5205820|Reactome:R-HSA-5205822|Reactome:R-HSA-5205824|Reactome:R-HSA-5205867|Reactome:R-HSA-5218952|Reactome:R-HSA-5229010|Reactome:R-HSA-5229203|Reactome:R-HSA-5661126|Reactome:R-HSA-8879123|Reactome:R-HSA-8934735 go.json PRMT activity http://purl.obolibrary.org/obo/GO_0016274 GO:0090256 biolink:BiologicalProcess regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0090256 GO:0031889 biolink:MolecularActivity urotensin receptor binding Binding to a urotensin receptor. go.json urotensin receptor ligand http://purl.obolibrary.org/obo/GO_0031889 GO:0031887 biolink:BiologicalProcess lipid droplet transport along microtubule The directed movement of a lipid droplet along a microtubule, mediated by motor proteins. go.json adiposome transport along microtubule|lipid body transport along microtubule|lipid particle transport along microtubule http://purl.obolibrary.org/obo/GO_0031887 GO:0031888 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031888 GO:0031885 biolink:MolecularActivity type 1 member 2 taste receptor binding Binding to a type 1 member 2 taste receptor. go.json type 1 member 2 taste receptor ligand http://purl.obolibrary.org/obo/GO_0031885 GO:0031886 biolink:MolecularActivity type 1 member 3 taste receptor binding Binding to a type 1 member 3 taste receptor. go.json sweet taste receptor binding|type 1 member 3 taste receptor ligand http://purl.obolibrary.org/obo/GO_0031886 GO:0090228 biolink:BiologicalProcess positive regulation of red or far-red light signaling pathway Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. go.json positive regulation of phytochrome signaling pathway|positive regulation of red or far-red light signalling pathway http://purl.obolibrary.org/obo/GO_0090228 GO:0090229 biolink:BiologicalProcess negative regulation of red or far-red light signaling pathway Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. go.json negative regulation of phytochrome signaling pathway|negative regulation of red or far-red light signalling pathway http://purl.obolibrary.org/obo/GO_0090229 GO:0090226 biolink:BiologicalProcess regulation of microtubule nucleation by Ran protein signal transduction The series of molecular signals in which a Ran GTPase relays a signal resulting in the modulation of the rate, frequency or extent of microtubule nucleation. go.json http://purl.obolibrary.org/obo/GO_0090226 GO:0090227 biolink:BiologicalProcess regulation of red or far-red light signaling pathway Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. go.json regulation of phytochrome signaling pathway|regulation of red or far-red light signalling pathway http://purl.obolibrary.org/obo/GO_0090227 GO:0016246 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016246 GO:0016247 biolink:MolecularActivity channel regulator activity Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. go.json http://purl.obolibrary.org/obo/GO_0016247 GO:0016248 biolink:MolecularActivity channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a channel. go.json http://purl.obolibrary.org/obo/GO_0016248 GO:0016249 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016249 GO:0016242 biolink:BiologicalProcess negative regulation of macroautophagy Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. go.json down regulation of macroautophagy|down-regulation of macroautophagy|downregulation of macroautophagy|inhibition of macroautophagy|negative regulation of starvation-induced autophagy http://purl.obolibrary.org/obo/GO_0016242 GO:0031883 biolink:MolecularActivity taste receptor binding Binding to a taste receptor. go.json taste receptor ligand http://purl.obolibrary.org/obo/GO_0031883 GO:0090220 biolink:BiologicalProcess chromosome localization to nuclear envelope involved in homologous chromosome segregation The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. go.json chromosome localisation to nuclear envelope involved in homologous chromosome segregation http://purl.obolibrary.org/obo/GO_0090220 GO:0016243 biolink:BiologicalProcess regulation of autophagosome size Any process that modulates the size of the autophagosome. go.json regulation of autophagic vacuole size http://purl.obolibrary.org/obo/GO_0016243 GO:0031884 biolink:MolecularActivity type 1 member 1 taste receptor binding Binding to a type 1 member 1 taste receptor. go.json type 1 member 1 taste receptor ligand http://purl.obolibrary.org/obo/GO_0031884 GO:0090221 biolink:BiologicalProcess mitotic spindle-templated microtubule nucleation The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle. go.json http://purl.obolibrary.org/obo/GO_0090221 GO:0031881 biolink:MolecularActivity type 4 somatostatin receptor binding Binding to a type 4 somatostatin receptor. go.json type 4 somatostatin receptor ligand http://purl.obolibrary.org/obo/GO_0031881 GO:0016244 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016244 GO:0031882 biolink:MolecularActivity type 5 somatostatin receptor binding Binding to a type 5 somatostatin receptor. go.json type 5 somatostatin receptor ligand http://purl.obolibrary.org/obo/GO_0031882 GO:0016245 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016245 GO:0090224 biolink:BiologicalProcess regulation of spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. go.json regulation of spindle organisation http://purl.obolibrary.org/obo/GO_0090224 GO:0031880 biolink:MolecularActivity type 3 somatostatin receptor binding Binding to a type 3 somatostatin receptor. go.json type 3 somatostatin receptor ligand http://purl.obolibrary.org/obo/GO_0031880 GO:0090225 biolink:BiologicalProcess obsolete regulation of spindle density OBSOLETE. Any process that modulates the number of microtubules in a given region of the spindle. go.json True http://purl.obolibrary.org/obo/GO_0090225 GO:0090222 biolink:BiologicalProcess centrosome-templated microtubule nucleation The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome. go.json http://purl.obolibrary.org/obo/GO_0090222 GO:0016240 biolink:BiologicalProcess autophagosome membrane docking The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. go.json autophagic vacuole docking http://purl.obolibrary.org/obo/GO_0016240 GO:0090223 biolink:BiologicalProcess chromatin-templated microtubule nucleation The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin. go.json http://purl.obolibrary.org/obo/GO_0090223 GO:0016241 biolink:BiologicalProcess regulation of macroautophagy Any process that modulates the frequency, rate or extent of macroautophagy. go.json regulation of starvation-induced autophagy http://purl.obolibrary.org/obo/GO_0016241 GO:0031878 biolink:MolecularActivity type 1 somatostatin receptor binding Binding to a type 1 somatostatin receptor. go.json type 1 somatostatin receptor ligand http://purl.obolibrary.org/obo/GO_0031878 GO:0031879 biolink:MolecularActivity type 2 somatostatin receptor binding Binding to a type 2 somatostatin receptor. go.json type 2 somatostatin receptor ligand http://purl.obolibrary.org/obo/GO_0031879 GO:0031876 biolink:MolecularActivity secretin receptor binding Binding to a secretin receptor. go.json secretin receptor ligand http://purl.obolibrary.org/obo/GO_0031876 GO:0031877 biolink:MolecularActivity somatostatin receptor binding Binding to a somatostatin receptor. go.json somatostatin receptor ligand http://purl.obolibrary.org/obo/GO_0031877 GO:0031874 biolink:MolecularActivity type 3 proteinase activated receptor binding Binding to a type 3 proteinase activated receptor. go.json type 3 proteinase activated receptor ligand http://purl.obolibrary.org/obo/GO_0031874 GO:0031875 biolink:MolecularActivity type 4 proteinase activated receptor binding Binding to a type 4 proteinase activated receptor. go.json type 4 proteinase activated receptor ligand http://purl.obolibrary.org/obo/GO_0031875 GO:0090239 biolink:BiologicalProcess regulation of histone H4 acetylation Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0090239 GO:0090237 biolink:BiologicalProcess regulation of arachidonic acid secretion Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0090237 GO:0090238 biolink:BiologicalProcess positive regulation of arachidonic acid secretion Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0090238 GO:0016257 biolink:BiologicalProcess N-glycan processing to secreted and cell-surface N-glycans The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus. go.json http://purl.obolibrary.org/obo/GO_0016257 GO:0016258 biolink:BiologicalProcess N-glycan diversification The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases. go.json http://purl.obolibrary.org/obo/GO_0016258 GO:0016259 biolink:BiologicalProcess selenocysteine metabolic process The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins. go.json selenocysteine metabolism http://purl.obolibrary.org/obo/GO_0016259 GO:0031872 biolink:MolecularActivity type 1 proteinase activated receptor binding Binding to a type 1 proteinase activated receptor. go.json thrombin receptor binding|type 1 proteinase activated receptor ligand http://purl.obolibrary.org/obo/GO_0031872 GO:0090231 biolink:BiologicalProcess regulation of spindle checkpoint Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. go.json http://purl.obolibrary.org/obo/GO_0090231 gocheck_do_not_manually_annotate GO:0016253 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016253 GO:0031873 biolink:MolecularActivity type 2 proteinase activated receptor binding Binding to a type 2 proteinase activated receptor. go.json type 2 proteinase activated receptor ligand http://purl.obolibrary.org/obo/GO_0031873 GO:0090232 biolink:BiologicalProcess positive regulation of spindle checkpoint Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. go.json spindle checkpoint activation http://purl.obolibrary.org/obo/GO_0090232 gocheck_do_not_manually_annotate GO:0016254 biolink:BiologicalProcess preassembly of GPI anchor in ER membrane The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. go.json preassembly of GPI anchor in endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0016254 GO:0031870 biolink:MolecularActivity thromboxane A2 receptor binding Binding to a thromboxane A2 receptor. go.json prostanoid TP receptor binding|thromboxane A2 receptor ligand http://purl.obolibrary.org/obo/GO_0031870 GO:0016255 biolink:BiologicalProcess attachment of GPI anchor to protein A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. go.json http://purl.obolibrary.org/obo/GO_0016255 GO:0031871 biolink:MolecularActivity proteinase activated receptor binding Binding to a proteinase activated receptor. go.json proteinase activated receptor ligand http://purl.obolibrary.org/obo/GO_0031871 GO:0090230 biolink:BiologicalProcess regulation of centromere complex assembly Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. go.json centromere licensing http://purl.obolibrary.org/obo/GO_0090230 GO:0016256 biolink:BiologicalProcess N-glycan processing to lysosome The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome. go.json http://purl.obolibrary.org/obo/GO_0016256 GO:0090235 biolink:BiologicalProcess regulation of metaphase plate congression Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. go.json regulation of chromosome congression http://purl.obolibrary.org/obo/GO_0090235 GO:0090236 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in somitogenesis OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. go.json True http://purl.obolibrary.org/obo/GO_0090236 GO:0016250 biolink:MolecularActivity N-sulfoglucosamine sulfohydrolase activity Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate. EC:3.10.1.1|MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN|RHEA:17881|Reactome:R-HSA-1678708|Reactome:R-HSA-2090043|Reactome:R-HSA-2263444|Reactome:R-HSA-9036050 go.json 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)|N-sulfo-D-glucosamine sulfohydrolase activity|N-sulphoglucosamine sulphohydrolase activity|heparin sulfamidase activity|sulfoglucosamine sulfamidase activity|sulphamidase activity http://purl.obolibrary.org/obo/GO_0016250 GO:0090233 biolink:BiologicalProcess negative regulation of spindle checkpoint Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. go.json spindle checkpoint silencing http://purl.obolibrary.org/obo/GO_0090233 gocheck_do_not_manually_annotate GO:0016251 biolink:MolecularActivity RNA polymerase II general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. go.json GTF2 activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|basal RNA polymerase II transcription factor activity|general RNA polymerase II transcription factor activity|sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly http://purl.obolibrary.org/obo/GO_0016251 GO:0090234 biolink:BiologicalProcess regulation of kinetochore assembly Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. go.json regulation of NMS complex assembly|regulation of chromosome-kinetochore attachment http://purl.obolibrary.org/obo/GO_0090234 GO:0016252 biolink:MolecularActivity obsolete nonspecific RNA polymerase II transcription factor activity OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set. go.json nonspecific RNA polymerase II transcription factor activity True http://purl.obolibrary.org/obo/GO_0016252 GO:0006825 biolink:BiologicalProcess copper ion transport The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006825 GO:0006826 biolink:BiologicalProcess iron ion transport The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json ferric ion import|ferric ion transport|ferric iron import|ferric iron transport|ferric iron uptake|ferrous ion transport|ferrous iron transport|iron ion import|iron transport http://purl.obolibrary.org/obo/GO_0006826 GO:0006823 biolink:BiologicalProcess obsolete heavy metal ion transport OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. go.json heavy metal ion transport True http://purl.obolibrary.org/obo/GO_0006823 GO:0006824 biolink:BiologicalProcess cobalt ion transport The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json cobalt transport http://purl.obolibrary.org/obo/GO_0006824 GO:0006821 biolink:BiologicalProcess chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006821 GO:0006822 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006822 GO:0006820 biolink:BiologicalProcess monoatomic anion transport The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. go.json anion transport http://purl.obolibrary.org/obo/GO_0006820 GO:0006829 biolink:BiologicalProcess zinc ion transport The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json zinc II ion transport|zinc transport http://purl.obolibrary.org/obo/GO_0006829 GO:0006827 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006827 GO:0006828 biolink:BiologicalProcess manganese ion transport The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006828 GO:0006836 biolink:BiologicalProcess neurotransmitter transport The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. go.json sodium:neurotransmitter transport http://purl.obolibrary.org/obo/GO_0006836 goslim_pir GO:0006837 biolink:BiologicalProcess serotonin transport The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. go.json http://purl.obolibrary.org/obo/GO_0006837 GO:0006834 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006834 GO:0006835 biolink:BiologicalProcess dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json sodium:dicarboxylate transport http://purl.obolibrary.org/obo/GO_0006835 GO:0006832 biolink:BiologicalProcess obsolete small molecule transport OBSOLETE. (Was not defined before being made obsolete). go.json small molecule transport True http://purl.obolibrary.org/obo/GO_0006832 GO:0006833 biolink:BiologicalProcess water transport The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006833 GO:0006830 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006830 GO:0006831 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006831 GO:0006838 biolink:BiologicalProcess obsolete allantoin/allantoate transport OBSOLETE. (Was not defined before being made obsolete). go.json allantoin/allantoate transport True http://purl.obolibrary.org/obo/GO_0006838 GO:0006839 biolink:BiologicalProcess mitochondrial transport Transport of substances into, out of or within a mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0006839 goslim_drosophila GO:0006803 biolink:BiologicalProcess obsolete glutathione conjugation reaction OBSOLETE. (Was not defined before being made obsolete). go.json glutathione conjugation reaction True http://purl.obolibrary.org/obo/GO_0006803 GO:0006804 biolink:BiologicalProcess obsolete peroxidase reaction OBSOLETE. (Was not defined before being made obsolete). go.json peroxidase reaction True http://purl.obolibrary.org/obo/GO_0006804 GO:0006801 biolink:BiologicalProcess superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. go.json oxygen free radical metabolic process|oxygen free radical metabolism|superoxide free radical metabolic process|superoxide free radical metabolism|superoxide metabolism http://purl.obolibrary.org/obo/GO_0006801 GO:0006802 biolink:BiologicalProcess obsolete catalase reaction OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O. go.json catalase reaction|hydroperoxidase reaction True http://purl.obolibrary.org/obo/GO_0006802 GO:0006800 biolink:BiologicalProcess obsolete oxygen and reactive oxygen species metabolic process OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH). go.json oxygen and AOS metabolism|oxygen and ROI metabolism|oxygen and ROS metabolic process|oxygen and ROS metabolism|oxygen and active oxygen species metabolism|oxygen and reactive oxidative species metabolism|oxygen and reactive oxygen intermediate metabolism|oxygen and reactive oxygen species metabolic process|oxygen and reactive oxygen species metabolism True http://purl.obolibrary.org/obo/GO_0006800 GO:0006809 biolink:BiologicalProcess nitric oxide biosynthetic process The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. go.json nitric oxide anabolism|nitric oxide biosynthesis|nitric oxide formation|nitric oxide synthesis http://purl.obolibrary.org/obo/GO_0006809 GO:0006807 biolink:BiologicalProcess nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. go.json nitrogen compound metabolism http://purl.obolibrary.org/obo/GO_0006807 goslim_metagenomics|goslim_pir GO:0006808 biolink:BiologicalProcess regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization. go.json http://purl.obolibrary.org/obo/GO_0006808 goslim_metagenomics GO:0006805 biolink:BiologicalProcess xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. Wikipedia:Drug_metabolism|Wikipedia:Xenobiotic_metabolism go.json drug metabolic process|drug metabolism|xenobiotic metabolism http://purl.obolibrary.org/obo/GO_0006805 goslim_chembl|goslim_pir GO:0006806 biolink:BiologicalProcess obsolete insecticide resistance OBSOLETE. (Was not defined before being made obsolete). go.json insecticide resistance True http://purl.obolibrary.org/obo/GO_0006806 GO:0006814 biolink:BiologicalProcess sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json mitochondrial sodium/calcium ion exchange|sodium channel auxiliary protein activity|sodium transport|sodium/potassium transport|sodium:calcium exchange|sodium:solute transport http://purl.obolibrary.org/obo/GO_0006814 GO:0006815 biolink:BiologicalProcess obsolete sodium/potassium transport OBSOLETE. (Was not defined before being made obsolete). go.json sodium/potassium transport True http://purl.obolibrary.org/obo/GO_0006815 GO:0006812 biolink:BiologicalProcess monoatomic cation transport The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. go.json cation transport|di-, tri-valent inorganic cation transport|trivalent inorganic cation transport http://purl.obolibrary.org/obo/GO_0006812 GO:0006813 biolink:BiologicalProcess potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json K+ conductance|cellular potassium ion transport|low voltage-dependent potassium channel auxiliary protein activity|low voltage-gated potassium channel auxiliary protein activity|potassium conductance|potassium ion conductance|potassium transport|sodium/potassium transport http://purl.obolibrary.org/obo/GO_0006813 GO:0006810 biolink:BiologicalProcess transport The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. go.json single-organism transport http://purl.obolibrary.org/obo/GO_0006810 gocheck_do_not_annotate|goslim_candida|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant|prokaryote_subset GO:0006811 biolink:BiologicalProcess monoatomic ion transport The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. go.json ion transport http://purl.obolibrary.org/obo/GO_0006811 goslim_drosophila|goslim_pir|goslim_yeast GO:0006818 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006818 GO:0006819 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006819 GO:0006816 biolink:BiologicalProcess calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json calcium transport|mitochondrial sodium/calcium ion exchange|sodium:calcium exchange http://purl.obolibrary.org/obo/GO_0006816 GO:0006817 biolink:BiologicalProcess phosphate ion transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json phosphate transport http://purl.obolibrary.org/obo/GO_0006817 GO:0031869 biolink:MolecularActivity prostacyclin receptor binding Binding to a prostacyclin receptor. go.json prostacyclin receptor ligand|prostanoid IP receptor binding http://purl.obolibrary.org/obo/GO_0031869 GO:0031867 biolink:MolecularActivity EP4 subtype prostaglandin E2 receptor binding Binding to an EP4 subtype prostaglandin E2 receptor. go.json EP4 subtype prostaglandin E2 receptor ligand|prostanoid EP4 receptor binding http://purl.obolibrary.org/obo/GO_0031867 GO:0031868 biolink:MolecularActivity prostaglandin F2-alpha receptor binding Binding to a prostaglandin F2-alpha receptor. go.json prostaglandin F2-alpha receptor ligand|prostanoid FP receptor binding http://purl.obolibrary.org/obo/GO_0031868 GO:0031865 biolink:MolecularActivity EP2 subtype prostaglandin E2 receptor binding Binding to an EP2 subtype prostaglandin E2 receptor. go.json EP2 subtype prostaglandin E2 receptor ligand|prostanoid EP2 receptor binding http://purl.obolibrary.org/obo/GO_0031865 GO:0090161 biolink:BiologicalProcess Golgi ribbon formation The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. go.json http://purl.obolibrary.org/obo/GO_0090161 GO:0031866 biolink:MolecularActivity EP3 subtype prostaglandin E2 receptor binding Binding to an EP3 subtype prostaglandin E2 receptor. go.json EP3 subtype prostaglandin E2 receptor ligand|prostanoid EP3 receptor binding http://purl.obolibrary.org/obo/GO_0031866 GO:0090162 biolink:BiologicalProcess establishment of epithelial cell polarity The specification and formation of anisotropic intracellular organization of an epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0090162 GO:0031863 biolink:MolecularActivity prostaglandin D2 receptor binding Binding to a prostaglandin D2 receptor. go.json prostaglandin D2 receptor ligand|prostanoid DP receptor binding http://purl.obolibrary.org/obo/GO_0031863 GO:0031864 biolink:MolecularActivity EP1 subtype prostaglandin E2 receptor binding Binding to an EP1 subtype prostaglandin E2 receptor. go.json EP1 subtype prostaglandin E2 receptor ligand|prostanoid EP1 receptor binding http://purl.obolibrary.org/obo/GO_0031864 GO:0090160 biolink:BiologicalProcess Golgi to lysosome transport The directed movement of substances from the Golgi to lysosomes. go.json http://purl.obolibrary.org/obo/GO_0090160 GO:0016228 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016228 GO:0016229 biolink:MolecularActivity steroid dehydrogenase activity Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. go.json http://purl.obolibrary.org/obo/GO_0016229 GO:0016224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016224 GO:0016225 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016225 GO:0016226 biolink:BiologicalProcess iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. go.json iron-sulfur cluster biosynthesis|iron-sulphur cluster assembly http://purl.obolibrary.org/obo/GO_0016226 goslim_metagenomics|goslim_pombe GO:0016227 biolink:MolecularActivity obsolete tRNA sulfurtransferase activity OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide. go.json L-cysteine:tRNA sulfurtransferase activity|RNA sulfurtransferase activity|ribonucleate sulfurtransferase activity|tRNA sulfurtransferase activity|tRNA sulphurtransferase activity|transfer RNA sulfurtransferase activity|transfer RNA thiolase activity|transfer ribonucleate sulfurtransferase activity True http://purl.obolibrary.org/obo/GO_0016227 GO:0090165 biolink:BiologicalProcess regulation of secretion by asymmetric Golgi ribbon formation The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0090165 GO:0031861 biolink:MolecularActivity prolactin-releasing peptide receptor binding Binding to a prolactin-releasing peptide receptor. go.json prolactin-releasing peptide receptor ligand http://purl.obolibrary.org/obo/GO_0031861 GO:0016220 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016220 GO:0090166 biolink:BiologicalProcess Golgi disassembly A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. go.json Golgi apparatus disassembly http://purl.obolibrary.org/obo/GO_0090166 GO:0031862 biolink:MolecularActivity prostanoid receptor binding Binding to a prostanoid receptor. go.json prostanoid receptor ligand http://purl.obolibrary.org/obo/GO_0031862 GO:0090163 biolink:BiologicalProcess establishment of epithelial cell planar polarity The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue. go.json http://purl.obolibrary.org/obo/GO_0090163 GO:0016222 biolink:CellularComponent procollagen-proline 4-dioxygenase complex A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase. go.json procollagen-proline, 2-oxoglutarate-4-dioxygenase complex|prolyl 4-hydroxylase complex http://purl.obolibrary.org/obo/GO_0016222 GO:0090164 biolink:BiologicalProcess asymmetric Golgi ribbon formation The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity. go.json http://purl.obolibrary.org/obo/GO_0090164 GO:0016223 biolink:MolecularActivity beta-alanine-pyruvate transaminase activity Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine. EC:2.6.1.18|MetaCyc:2.6.1.18-RXN|RHEA:14077|Reactome:R-HSA-909776 go.json L-alanine:3-oxopropanoate aminotransferase activity|beta-alanine--pyruvate aminotransferase activity|beta-alanine-alpha-alanine transaminase activity|beta-alanine-pyruvate aminotransferase activity|omega-amino acid--pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0016223 GO:0031860 biolink:BiologicalProcess telomeric 3' overhang formation The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans. go.json telomere 3'-end processing|telomere end processing http://purl.obolibrary.org/obo/GO_0031860 GO:0090169 biolink:BiologicalProcess regulation of spindle assembly Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. go.json regulation of spindle formation http://purl.obolibrary.org/obo/GO_0090169 GO:0090167 biolink:BiologicalProcess Golgi distribution to daughter cells Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division. go.json Golgi apparatus distribution to daughter cells http://purl.obolibrary.org/obo/GO_0090167 GO:0090168 biolink:BiologicalProcess Golgi reassembly The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. go.json Golgi apparatus reassembly http://purl.obolibrary.org/obo/GO_0090168 GO:0031858 biolink:MolecularActivity pituitary adenylate cyclase-activating polypeptide receptor binding Binding to a pituitary adenylate cyclase-activating polypeptide receptor. go.json PACAP receptor binding|pituitary adenylate cyclase activating peptide receptor binding|pituitary adenylate cyclase-activating peptide receptor ligand http://purl.obolibrary.org/obo/GO_0031858 GO:0031859 biolink:MolecularActivity platelet activating factor receptor binding Binding to a platelet activating factor receptor. go.json platelet activating factor receptor ligand http://purl.obolibrary.org/obo/GO_0031859 GO:0031856 biolink:MolecularActivity parathyroid hormone receptor binding Binding to a parathyroid hormone receptor. go.json parathyroid hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031856 GO:0031857 biolink:MolecularActivity type 1 parathyroid hormone receptor binding Binding to a type 1 parathyroid hormone receptor. go.json type 1 parathyroid hormone receptor ligand http://purl.obolibrary.org/obo/GO_0031857 GO:0031854 biolink:MolecularActivity orexigenic neuropeptide QRFP receptor binding Binding to an orexigenic neuropeptide QRFP receptor. go.json orexigenic neuropeptide QRFP receptor ligand http://purl.obolibrary.org/obo/GO_0031854 GO:0090172 biolink:BiologicalProcess obsolete microtubule cytoskeleton organization involved in homologous chromosome segregation OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis. go.json microtubule cytoskeleton organisation involved in homologous chromosome segregation|microtubule organization involved in chromosome pairing True http://purl.obolibrary.org/obo/GO_0090172 GO:0031855 biolink:MolecularActivity oxytocin receptor binding Binding to an oxytocin receptor. go.json oxytocin receptor ligand http://purl.obolibrary.org/obo/GO_0031855 GO:0090173 biolink:BiologicalProcess regulation of synaptonemal complex assembly Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed. go.json http://purl.obolibrary.org/obo/GO_0090173 GO:0031852 biolink:MolecularActivity mu-type opioid receptor binding Binding to a mu-type opioid receptor. go.json morphine receptor binding|mu-type opioid receptor ligand http://purl.obolibrary.org/obo/GO_0031852 GO:0090170 biolink:BiologicalProcess regulation of Golgi inheritance Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. go.json http://purl.obolibrary.org/obo/GO_0090170 GO:0031853 biolink:MolecularActivity nociceptin receptor binding Binding to a nociceptin receptor. go.json nociceptin receptor ligand http://purl.obolibrary.org/obo/GO_0031853 GO:0090171 biolink:BiologicalProcess chondrocyte morphogenesis The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. go.json http://purl.obolibrary.org/obo/GO_0090171 GO:0016239 biolink:BiologicalProcess positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. go.json activation of macroautophagy|positive regulation of starvation-induced autophagy|stimulation of macroautophagy|up regulation of macroautophagy|up-regulation of macroautophagy|upregulation of macroautophagy http://purl.obolibrary.org/obo/GO_0016239 GO:0016235 biolink:CellularComponent aggresome An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. Wikipedia:Aggresome go.json http://purl.obolibrary.org/obo/GO_0016235 GO:0016236 biolink:BiologicalProcess macroautophagy The autophagic process that proceeds via the formation of an autophagosome. go.json autophagy|selective autophagy http://purl.obolibrary.org/obo/GO_0016236 GO:0016237 biolink:BiologicalProcess microautophagy A type of autophagy where cytosolic components are ingested by late endosomes, lysosomes or yeast-type lytic vacuoles by direct invagination of the compartment membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. go.json lysosomal microautophagy http://purl.obolibrary.org/obo/GO_0016237 GO:0016238 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016238 GO:0031850 biolink:MolecularActivity delta-type opioid receptor binding Binding to a delta-type opioid receptor. go.json delta-type opioid receptor ligand|enkephalin receptor binding http://purl.obolibrary.org/obo/GO_0031850 GO:0090176 biolink:BiologicalProcess microtubule cytoskeleton organization involved in establishment of planar polarity A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity. go.json microtubule cytoskeleton organisation involved in establishment of planar polarity http://purl.obolibrary.org/obo/GO_0090176 GO:0016231 biolink:MolecularActivity beta-N-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. go.json http://purl.obolibrary.org/obo/GO_0016231 GO:0016232 biolink:MolecularActivity HNK-1 sulfotransferase activity Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). Reactome:R-HSA-6786048 go.json HNK-1 sulphotransferase activity http://purl.obolibrary.org/obo/GO_0016232 GO:0090177 biolink:BiologicalProcess establishment of planar polarity involved in neural tube closure Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. go.json http://purl.obolibrary.org/obo/GO_0090177 GO:0031851 biolink:MolecularActivity kappa-type opioid receptor binding Binding to a kappa-type opioid receptor. go.json dynorphin receptor binding|kappa-type opioid receptor ligand http://purl.obolibrary.org/obo/GO_0031851 GO:0090174 biolink:BiologicalProcess organelle membrane fusion The joining of two lipid bilayers to form a single organelle membrane. go.json http://purl.obolibrary.org/obo/GO_0090174 GO:0016233 biolink:BiologicalProcess telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. go.json telomere end protection http://purl.obolibrary.org/obo/GO_0016233 GO:0090175 biolink:BiologicalProcess regulation of establishment of planar polarity Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. go.json http://purl.obolibrary.org/obo/GO_0090175 GO:0016234 biolink:CellularComponent inclusion body A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. NIF_Subcellular:sao120573470|Wikipedia:Inclusion_bodies go.json cellular inclusion|neuronal cytoplasmic inclusion http://purl.obolibrary.org/obo/GO_0016234 GO:0090178 biolink:BiologicalProcess regulation of establishment of planar polarity involved in neural tube closure Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. go.json http://purl.obolibrary.org/obo/GO_0090178 GO:0090179 biolink:BiologicalProcess planar cell polarity pathway involved in neural tube closure The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure. go.json http://purl.obolibrary.org/obo/GO_0090179 GO:0016230 biolink:MolecularActivity sphingomyelin phosphodiesterase activator activity Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase. go.json neutral sphingomyelinase activator http://purl.obolibrary.org/obo/GO_0016230 GO:0031847 biolink:MolecularActivity type 1 neurotensin receptor binding Binding to a type 1 neurotensin receptor. go.json type 1 neurotensin receptor ligand http://purl.obolibrary.org/obo/GO_0031847 GO:0031848 biolink:BiologicalProcess protection from non-homologous end joining at telomere A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. go.json protection from NHEJ-mediated telomere fusion http://purl.obolibrary.org/obo/GO_0031848 GO:0031845 biolink:MolecularActivity type 5 neuropeptide Y receptor binding Binding to a type 5 neuropeptide Y receptor. go.json type 5 neuropeptide Y receptor ligand http://purl.obolibrary.org/obo/GO_0031845 GO:0006889 biolink:BiologicalProcess obsolete regulation of calcium in ER OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum. go.json regulation of calcium in ER True http://purl.obolibrary.org/obo/GO_0006889 GO:0031846 biolink:MolecularActivity neurotensin receptor binding Binding to a neurotensin receptor. go.json neurotensin receptor ligand http://purl.obolibrary.org/obo/GO_0031846 GO:0006887 biolink:BiologicalProcess exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. Wikipedia:Exocytosis go.json nonselective vesicle exocytosis|vesicle exocytosis http://purl.obolibrary.org/obo/GO_0006887 goslim_yeast GO:0031843 biolink:MolecularActivity type 2 neuropeptide Y receptor binding Binding to a type 2 neuropeptide Y receptor. go.json type 2 neuropeptide Y receptor ligand http://purl.obolibrary.org/obo/GO_0031843 GO:0006888 biolink:BiologicalProcess endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. go.json ER to Golgi transport|ER to Golgi vesicle-mediated transport|anterograde (ER to Golgi) transport|anterograde transport, ER to Golgi|anterograde transport, endoplasmic reticulum to Golgi|anterograde vesicle-mediated transport, ER to Golgi|anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi|endoplasmic reticulum to Golgi transport|rough ER to cis-Golgi transport|rough ER to cis-Golgi vesicle-mediated transport|rough endoplasmic reticulum to cis-Golgi transport|rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport http://purl.obolibrary.org/obo/GO_0006888 GO:0090140 biolink:BiologicalProcess regulation of mitochondrial fission Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. go.json regulation of mitochondrial division http://purl.obolibrary.org/obo/GO_0090140 GO:0031844 biolink:MolecularActivity type 4 neuropeptide Y receptor binding Binding to a type 4 neuropeptide Y receptor. go.json pancreatic polypeptide receptor binding|type 4 neuropeptide Y receptor ligand http://purl.obolibrary.org/obo/GO_0031844 GO:0006885 biolink:BiologicalProcess regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. go.json hydrogen ion homeostasis http://purl.obolibrary.org/obo/GO_0006885 GO:0031841 biolink:MolecularActivity neuropeptide Y receptor binding Binding to a neuropeptide Y receptor. go.json NPY receptor binding|neuropeptide Y receptor ligand http://purl.obolibrary.org/obo/GO_0031841 GO:0006886 biolink:BiologicalProcess intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. go.json copper-induced intracellular protein transport http://purl.obolibrary.org/obo/GO_0006886 goslim_generic|prokaryote_subset GO:0031842 biolink:MolecularActivity type 1 neuropeptide Y receptor binding Binding to a type 1 neuropeptide Y receptor. go.json type 1 neuropeptide Y receptor ligand http://purl.obolibrary.org/obo/GO_0031842 GO:0006883 biolink:BiologicalProcess intracellular sodium ion homeostasis A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. go.json cellular sodium ion homeostasis http://purl.obolibrary.org/obo/GO_0006883 GO:0006884 biolink:BiologicalProcess cell volume homeostasis Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. go.json regulation of cell volume http://purl.obolibrary.org/obo/GO_0006884 GO:0006881 biolink:BiologicalProcess extracellular sequestering of iron ion The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system. go.json extracellular iron ion retention|extracellular iron ion sequestering|extracellular iron ion sequestration|extracellular iron ion storage|extracellular retention of iron ion|extracellular sequestration of iron ion|extracellular storage of iron ion http://purl.obolibrary.org/obo/GO_0006881 GO:0006882 biolink:BiologicalProcess intracellular zinc ion homeostasis A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell. go.json cellular zinc ion homeostasis|zinc homeostasis http://purl.obolibrary.org/obo/GO_0006882 GO:0006880 biolink:BiologicalProcess intracellular sequestering of iron ion The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system. go.json intracellular iron ion retention|intracellular iron ion sequestering|intracellular iron ion sequestration|intracellular iron ion storage|intracellular retention of iron ion|intracellular sequestration of iron ion|intracellular storage of iron ion http://purl.obolibrary.org/obo/GO_0006880 GO:0031849 biolink:MolecularActivity olfactory receptor binding Binding to an olfactory receptor. go.json olfactory receptor ligand http://purl.obolibrary.org/obo/GO_0031849 GO:0016206 biolink:MolecularActivity catechol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. EC:2.1.1.6|MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN|Reactome:R-HSA-175983|Reactome:R-HSA-8955010 go.json COMT I|COMT II|MB-COMT (membrane-bound form of catechol-O-methyltransferase)|S-COMT (soluble form of catechol-O-methyltransferase)|S-adenosyl-L-methionine:catechol O-methyltransferase activity|catechol methyltransferase activity|catecholamine O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016206 GO:0016207 biolink:MolecularActivity 4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA. EC:6.2.1.12|KEGG_REACTION:R01616|MetaCyc:4-COUMARATE--COA-LIGASE-RXN|RHEA:19641 go.json 4-coumarate-CoA synthetase activity|4-coumarate:CoA ligase (AMP-forming)|4-coumarate:CoA ligase activity|4-coumarate:coenzyme A ligase activity|4-coumaroyl-CoA synthase activity|4-coumaroyl-CoA synthetase activity|4-coumaryl-CoA synthetase activity|4CL|caffeolyl coenzyme A synthetase activity|feruloyl CoA ligase activity|feruloyl coenzyme A synthetase activity|hydroxycinnamate:CoA ligase activity|hydroxycinnamoyl CoA synthetase activity|p-coumaroyl CoA ligase activity|p-coumaryl coenzyme A synthetase activity|p-coumaryl-CoA ligase activity|p-coumaryl-CoA synthetase activity|p-hydroxycinnamic acid:CoA ligase activity|p-hydroxycinnamoyl coenzyme A synthetase activity|sinapoyl coenzyme A synthetase activity http://purl.obolibrary.org/obo/GO_0016207 GO:0090149 biolink:BiologicalProcess mitochondrial membrane fission A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission. go.json membrane fission involved in mitochondrial fission|mitochondrial membrane scission http://purl.obolibrary.org/obo/GO_0090149 GO:0016208 biolink:MolecularActivity AMP binding Binding to AMP, adenosine monophosphate. go.json http://purl.obolibrary.org/obo/GO_0016208 GO:0016209 biolink:MolecularActivity antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. go.json http://purl.obolibrary.org/obo/GO_0016209 goslim_generic|goslim_metagenomics|goslim_pir|prokaryote_subset GO:0016202 biolink:BiologicalProcess regulation of striated muscle tissue development Any process that modulates the frequency, rate or extent of striated muscle development. go.json http://purl.obolibrary.org/obo/GO_0016202 GO:0016203 biolink:BiologicalProcess muscle attachment The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall). go.json http://purl.obolibrary.org/obo/GO_0016203 GO:0016204 biolink:BiologicalProcess determination of muscle attachment site The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site. go.json http://purl.obolibrary.org/obo/GO_0016204 GO:0016205 biolink:MolecularActivity selenocysteine methyltransferase activity Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine. EC:2.1.1.280|MetaCyc:RXN-11061|RHEA:26341 go.json http://purl.obolibrary.org/obo/GO_0016205 GO:0090143 biolink:BiologicalProcess nucleoid organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined. go.json nucleoid organisation http://purl.obolibrary.org/obo/GO_0090143 GO:0031840 biolink:MolecularActivity type 2 neuromedin U receptor binding Binding to a type 2 neuromedin U receptor. go.json type 2 neuromedin U receptor ligand http://purl.obolibrary.org/obo/GO_0031840 GO:0090144 biolink:BiologicalProcess mitochondrial nucleoid organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined. go.json mitochondrial nucleoid organisation http://purl.obolibrary.org/obo/GO_0090144 GO:0090141 biolink:BiologicalProcess positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. go.json positive regulation of mitochondrial division http://purl.obolibrary.org/obo/GO_0090141 GO:0016200 biolink:BiologicalProcess synaptic target attraction The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets. go.json http://purl.obolibrary.org/obo/GO_0016200 GO:0016201 biolink:BiologicalProcess synaptic target inhibition The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source. go.json http://purl.obolibrary.org/obo/GO_0016201 GO:0090142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090142 GO:0090147 biolink:BiologicalProcess obsolete regulation of establishment of mitochondrion localization involved in mitochondrial fission OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission. go.json regulation of establishment of mitochondrion localisation involved in mitochondrial fission|regulation of mitochondrial localization involved in mitochondrial fission True http://purl.obolibrary.org/obo/GO_0090147 GO:0090148 biolink:BiologicalProcess membrane fission A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. go.json membrane scission http://purl.obolibrary.org/obo/GO_0090148 GO:0090145 biolink:BiologicalProcess obsolete mitochondrial nucleoid organization involved in mitochondrial fission OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division. go.json mitochondrial nucleoid organisation involved in mitochondrial fission True http://purl.obolibrary.org/obo/GO_0090145 GO:0090146 biolink:BiologicalProcess obsolete establishment of mitochondrion localization involved in mitochondrial fission OBSOLETE. The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission. go.json establishment of mitochondrion localisation involved in mitochondrial fission|mitochondrial localization involved in mitochondrial fission True http://purl.obolibrary.org/obo/GO_0090146 GO:0031836 biolink:MolecularActivity neuromedin K receptor binding Binding to a neuromedin K receptor. go.json neurokinin-B receptor binding|neuromedin K receptor ligand http://purl.obolibrary.org/obo/GO_0031836 GO:0031837 biolink:MolecularActivity substance K receptor binding Binding to a substance K receptor. go.json neurokinin-A receptor binding|substance K receptor ligand http://purl.obolibrary.org/obo/GO_0031837 GO:0031834 biolink:MolecularActivity neurokinin receptor binding Binding to a neurokinin receptor. go.json neurokinin receptor ligand http://purl.obolibrary.org/obo/GO_0031834 GO:0031835 biolink:MolecularActivity substance P receptor binding Binding to a substance P receptor. go.json neurokinin-1 receptor binding|substance P receptor ligand http://purl.obolibrary.org/obo/GO_0031835 GO:0090150 biolink:BiologicalProcess establishment of protein localization to membrane The directed movement of a protein to a specific location in a membrane. go.json establishment of protein localisation in membrane|establishment of protein localization in membrane http://purl.obolibrary.org/obo/GO_0090150 GO:0031832 biolink:MolecularActivity type 6 serotonin receptor binding Binding to a type 6 serotonin receptor. go.json 5-hydroxytryptamine 6 receptor binding|type 6 serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031832 GO:0006898 biolink:BiologicalProcess receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. Wikipedia:Receptor-mediated_endocytosis go.json receptor mediated endocytosis http://purl.obolibrary.org/obo/GO_0006898 GO:0006899 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006899 GO:0090151 biolink:BiologicalProcess establishment of protein localization to mitochondrial membrane The directed movement of a protein to a specific location in the mitochondrial membrane. go.json establishment of protein localisation in mitochondrial membrane|establishment of protein localization in mitochondrial membrane http://purl.obolibrary.org/obo/GO_0090151 GO:0031833 biolink:MolecularActivity type 7 serotonin receptor binding Binding to a type 7 serotonin receptor. go.json 5-hydroxytryptamine 7 receptor binding|type 7 serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031833 GO:0006896 biolink:BiologicalProcess Golgi to vacuole transport The directed movement of substances from the Golgi to the vacuole. go.json Golgi to vacuole vesicle-mediated transport http://purl.obolibrary.org/obo/GO_0006896 GO:0031830 biolink:MolecularActivity type 5A serotonin receptor binding Binding to a type 5A serotonin receptor. go.json 5-hydroxytryptamine 5A receptor binding|type 5A serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031830 GO:0006897 biolink:BiologicalProcess endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. Wikipedia:Endocytosis go.json endocytic import into cell|nonselective vesicle endocytosis|plasma membrane invagination|vesicle endocytosis http://purl.obolibrary.org/obo/GO_0006897 goslim_yeast GO:0031831 biolink:MolecularActivity type 5B serotonin receptor binding Binding to a type 5B serotonin receptor. go.json 5-hydroxytryptamine 5B receptor binding|type 5B serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031831 GO:0006894 biolink:BiologicalProcess obsolete Golgi to secretory vesicle transport OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release. go.json Golgi to secretory vesicle transport|Golgi to secretory vesicle transport, vesicle-mediated True http://purl.obolibrary.org/obo/GO_0006894 GO:0006895 biolink:BiologicalProcess Golgi to endosome transport The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. go.json Golgi to endosome vesicle-mediated transport|TGN to endosome transport|trans-Golgi to endosome transport http://purl.obolibrary.org/obo/GO_0006895 GO:0006892 biolink:BiologicalProcess post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. go.json post-Golgi transport http://purl.obolibrary.org/obo/GO_0006892 GO:0006893 biolink:BiologicalProcess Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. go.json Golgi to plasma membrane vesicle-mediated transport http://purl.obolibrary.org/obo/GO_0006893 GO:0006890 biolink:BiologicalProcess retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. go.json cis-Golgi to rough ER transport|cis-Golgi to rough ER vesicle-mediated transport|cis-Golgi to rough endoplasmic reticulum transport|cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport|retrograde (Golgi to ER) transport|retrograde transport, Golgi to ER|retrograde transport, Golgi to endoplasmic reticulum|retrograde vesicle-mediated transport, Golgi to ER http://purl.obolibrary.org/obo/GO_0006890 GO:0006891 biolink:BiologicalProcess intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). go.json intra-Golgi transport http://purl.obolibrary.org/obo/GO_0006891 GO:0031838 biolink:CellularComponent haptoglobin-hemoglobin complex A protein complex formed by the stable binding of a haptoglobin to hemoglobin. go.json http://purl.obolibrary.org/obo/GO_0031838 GO:0031839 biolink:MolecularActivity type 1 neuromedin U receptor binding Binding to a type 1 neuromedin U receptor. go.json type 1 neuromedin U receptor ligand http://purl.obolibrary.org/obo/GO_0031839 GO:0016217 biolink:MolecularActivity N-ethylammeline chlorohydrolase activity Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+. MetaCyc:R465-RXN go.json http://purl.obolibrary.org/obo/GO_0016217 GO:0016218 biolink:MolecularActivity polyketide synthase activity Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. go.json PKS activity http://purl.obolibrary.org/obo/GO_0016218 GO:0016219 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016219 GO:0016213 biolink:MolecularActivity linoleoyl-CoA desaturase activity Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA). EC:1.14.19.3|MetaCyc:1.14.19.3-RXN|Reactome:R-HSA-2046084|Reactome:R-HSA-2046096|Reactome:R-HSA-2046097|Reactome:R-HSA-2046099 go.json delta(6)-acyl CoA desaturase activity|delta(6)-desaturase activity|delta(6)-fatty acyl-CoA desaturase activity|delta6-acyl CoA desaturase activity|delta6-desaturase activity|delta6-fatty acyl-CoA desaturase activity|fatty acid 6-desaturase activity|fatty acid delta(6)-desaturase activity|fatty acid delta6-desaturase activity|linoleate desaturase activity|linoleic acid desaturase activity|linoleic desaturase activity|linoleoyl CoA desaturase activity|linoleoyl-coenzyme A desaturase activity|long-chain fatty acid delta(6)-desaturase activity|long-chain fatty acid delta6-desaturase activity http://purl.obolibrary.org/obo/GO_0016213 GO:0016214 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0016214 GO:0016215 biolink:MolecularActivity acyl-CoA desaturase activity Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O. RHEA:25416 go.json CoA desaturase activity http://purl.obolibrary.org/obo/GO_0016215 GO:0016216 biolink:MolecularActivity isopenicillin-N synthase activity Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N. EC:1.21.3.1|KEGG_REACTION:R04872|MetaCyc:1.21.3.1-RXN|RHEA:22428 go.json N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)|isopenicillin N synthase activity|isopenicillin-N synthetase activity http://purl.obolibrary.org/obo/GO_0016216 GO:0090154 biolink:BiologicalProcess positive regulation of sphingolipid biosynthetic process Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). go.json http://purl.obolibrary.org/obo/GO_0090154 GO:0016210 biolink:MolecularActivity naringenin-chalcone synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2. EC:2.3.1.74|MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN|RHEA:11128 go.json DOCS|malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) http://purl.obolibrary.org/obo/GO_0016210 GO:0090155 biolink:BiologicalProcess negative regulation of sphingolipid biosynthetic process Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). go.json negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis http://purl.obolibrary.org/obo/GO_0090155 GO:0090152 biolink:BiologicalProcess establishment of protein localization to mitochondrial membrane involved in mitochondrial fission The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission. go.json establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission|establishment of protein localization in mitochondrial membrane involved in mitochondrial fission http://purl.obolibrary.org/obo/GO_0090152 GO:0016211 biolink:MolecularActivity ammonia ligase activity Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. EC:6.3.1.- go.json http://purl.obolibrary.org/obo/GO_0016211 GO:0016212 biolink:MolecularActivity kynurenine-oxoglutarate transaminase activity Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. EC:2.6.1.7|MetaCyc:2.6.1.7-RXN|RHEA:20964|Reactome:R-HSA-893583|Reactome:R-HSA-893596|Reactome:R-HSA-901097 go.json L-kynurenine aminotransferase activity|L-kynurenine:2-oxoglutarate aminotransferase activity|kynurenine 2-oxoglutarate transaminase activity|kynurenine aminotransferase activity|kynurenine transaminase (cyclizing)|kynurenine--oxoglutarate aminotransferase activity|kynurenine-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0016212 GO:0090153 biolink:BiologicalProcess regulation of sphingolipid biosynthetic process Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). go.json http://purl.obolibrary.org/obo/GO_0090153 GO:0090158 biolink:BiologicalProcess endoplasmic reticulum membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. go.json endoplasmic reticulum membrane organisation http://purl.obolibrary.org/obo/GO_0090158 GO:0090159 biolink:BiologicalProcess sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization. go.json sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation http://purl.obolibrary.org/obo/GO_0090159 GO:0090156 biolink:BiologicalProcess intracellular sphingolipid homeostasis A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell. go.json cellular sphingolipid homeostasis http://purl.obolibrary.org/obo/GO_0090156 GO:0090157 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090157 GO:0031825 biolink:MolecularActivity type 1F serotonin receptor binding Binding to a type 1F serotonin receptor. go.json 5-hydroxytryptamine 1F receptor binding|type 1F serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031825 GO:0006869 biolink:BiologicalProcess lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. go.json http://purl.obolibrary.org/obo/GO_0006869 goslim_drosophila|goslim_pir|goslim_yeast GO:0031826 biolink:MolecularActivity type 2A serotonin receptor binding Binding to a type 2A serotonin receptor. go.json 5-hydroxytryptamine 2A receptor binding|type 2A serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031826 GO:0031823 biolink:MolecularActivity type 1D serotonin receptor binding Binding to a type 1D serotonin receptor. go.json 5-hydroxytryptamine 1D receptor binding|type 1D serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031823 GO:0006867 biolink:BiologicalProcess asparagine transport The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-asparagine transport http://purl.obolibrary.org/obo/GO_0006867 GO:0031824 biolink:MolecularActivity type 1E serotonin receptor binding Binding to a type 1E serotonin receptor. go.json 5-hydroxytryptamine 1E receptor binding|type 1E serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031824 GO:0006868 biolink:BiologicalProcess glutamine transport The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-glutamine transport http://purl.obolibrary.org/obo/GO_0006868 GO:0006865 biolink:BiologicalProcess amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006865 goslim_pir|goslim_yeast GO:0031821 biolink:MolecularActivity G protein-coupled serotonin receptor binding Binding to a metabotropic serotonin receptor. go.json G-protein coupled serotonin receptor binding|metabotropic 5-hydroxytryptamine receptor binding|metabotropic serotonin receptor binding|metabotropic serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031821 GO:0006866 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006866 GO:0031822 biolink:MolecularActivity type 1B serotonin receptor binding Binding to a type 1B serotonin receptor. go.json 5-hydroxytryptamine 1B receptor binding|type 1B serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031822 GO:0006863 biolink:BiologicalProcess purine nucleobase transport The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json purine base transmembrane transport|purine base transport|purine transmembrane transport|purine transport http://purl.obolibrary.org/obo/GO_0006863 GO:0031820 biolink:MolecularActivity P2Y11 nucleotide receptor binding Binding to a P2Y11 nucleotide receptor. go.json P2Y11 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031820 GO:0006864 biolink:BiologicalProcess pyrimidine nucleotide transport The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0006864 GO:0006861 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006861 GO:0006862 biolink:BiologicalProcess nucleotide transport The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0006862 GO:0006860 biolink:BiologicalProcess extracellular amino acid transport The directed extracellular movement of amino acids. go.json http://purl.obolibrary.org/obo/GO_0006860 GO:0031829 biolink:MolecularActivity type 4 serotonin receptor binding Binding to a type 4 serotonin receptor. go.json 5-hydroxytryptamine 4 receptor binding|type 4 serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031829 GO:0031827 biolink:MolecularActivity type 2B serotonin receptor binding Binding to a type 2B serotonin receptor. go.json 5-hydroxytryptamine 2B receptor binding|type 2B serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031827 GO:0031828 biolink:MolecularActivity type 2C serotonin receptor binding Binding to a type 2C serotonin receptor. go.json 5-hydroxytryptamine 2C receptor binding|type 2C serotonin receptor ligand http://purl.obolibrary.org/obo/GO_0031828 GO:0031814 biolink:MolecularActivity P2Y4 nucleotide receptor binding Binding to a P2Y4 nucleotide receptor. go.json P2Y4 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031814 GO:0031815 biolink:MolecularActivity P2Y5 nucleotide receptor binding Binding to a P2Y5 nucleotide receptor. go.json P2Y5 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031815 GO:0031812 biolink:MolecularActivity P2Y1 nucleotide receptor binding Binding to a P2Y1 nucleotide receptor. go.json P2Y1 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031812 GO:0006878 biolink:BiologicalProcess intracellular copper ion homeostasis A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell. go.json cellular copper ion homeostasis|copper homeostasis http://purl.obolibrary.org/obo/GO_0006878 GO:0031813 biolink:MolecularActivity P2Y2 nucleotide receptor binding Binding to a P2Y2 nucleotide receptor. go.json P2Y2 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031813 GO:0006879 biolink:BiologicalProcess intracellular iron ion homeostasis A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. go.json cellular iron ion homeostasis|iron homeostasis http://purl.obolibrary.org/obo/GO_0006879 GO:0031810 biolink:MolecularActivity H4 histamine receptor binding Binding to a H4 histamine receptor. go.json H4 histamine receptor ligand http://purl.obolibrary.org/obo/GO_0031810 GO:0006876 biolink:BiologicalProcess obsolete intracellular cadmium ion homeostasis OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of cadmium ions within a cell. go.json cadmium homeostasis|cellular cadmium ion homeostasis True http://purl.obolibrary.org/obo/GO_0006876 GO:0031811 biolink:MolecularActivity G protein-coupled nucleotide receptor binding Binding to a G protein-coupled (metabotropic) nucleotide receptor. go.json G-protein coupled nucleotide receptor binding|P2Y receptor binding|metabotropic nucleotide receptor binding|metabotropic nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031811 GO:0006877 biolink:BiologicalProcess intracellular cobalt ion homeostasis A homeostatic process involved in the maintenance of a steady state level of cobalt ions within a cell. go.json cellular cobalt ion homeostasis|cobalt homeostasis http://purl.obolibrary.org/obo/GO_0006877 GO:0006874 biolink:BiologicalProcess intracellular calcium ion homeostasis A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. go.json cellular calcium ion homeostasis|regulation of calcium ion concentration http://purl.obolibrary.org/obo/GO_0006874 GO:0006875 biolink:BiologicalProcess obsolete intracellular metal ion homeostasis OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of metal ions within a cell. go.json cellular heavy metal ion homeostasis|cellular metal ion homeostasis True http://purl.obolibrary.org/obo/GO_0006875 GO:0006872 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006872 GO:0006873 biolink:BiologicalProcess intracellular monoatomic ion homeostasis A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. go.json cellular ion homeostasis|cellular monoatomic ion homeostasis http://purl.obolibrary.org/obo/GO_0006873 goslim_yeast GO:0006870 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006870 GO:0006871 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006871 GO:0031818 biolink:MolecularActivity P2Y9 nucleotide receptor binding Binding to a P2Y9 nucleotide receptor. go.json P2Y9 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031818 GO:0031819 biolink:MolecularActivity P2Y10 nucleotide receptor binding Binding to a P2Y10 nucleotide receptor. go.json P2Y10 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031819 GO:0031816 biolink:MolecularActivity P2Y6 nucleotide receptor binding Binding to a P2Y6 nucleotide receptor. go.json P2Y6 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031816 GO:0031817 biolink:MolecularActivity P2Y8 nucleotide receptor binding Binding to a P2Y8 nucleotide receptor. go.json P2Y8 nucleotide receptor ligand http://purl.obolibrary.org/obo/GO_0031817 GO:0031803 biolink:MolecularActivity type 6 metabotropic glutamate receptor binding Binding to a type 6 metabotropic glutamate receptor. go.json type 6 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031803 GO:0006847 biolink:BiologicalProcess plasma membrane acetate transport The directed movement of acetate across a plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0006847 GO:0031804 biolink:MolecularActivity type 7 metabotropic glutamate receptor binding Binding to a type 7 metabotropic glutamate receptor. go.json type 7 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031804 GO:0006848 biolink:BiologicalProcess pyruvate transport The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006848 GO:0090180 biolink:BiologicalProcess positive regulation of thiamine biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. go.json positive regulation of thiamin biosynthetic process http://purl.obolibrary.org/obo/GO_0090180 GO:0031801 biolink:MolecularActivity type 4 metabotropic glutamate receptor binding Binding to a type 4 metabotropic glutamate receptor. go.json type 4 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031801 GO:0006845 biolink:BiologicalProcess obsolete mitochondrial aspartate/glutamate transport OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion. go.json mitochondrial aspartate/glutamate transport True http://purl.obolibrary.org/obo/GO_0006845 GO:0031802 biolink:MolecularActivity type 5 metabotropic glutamate receptor binding Binding to a type 5 metabotropic glutamate receptor. go.json type 5 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031802 GO:0006846 biolink:BiologicalProcess acetate transport The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006846 GO:0090183 biolink:BiologicalProcess regulation of kidney development Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json regulation of nephrogenesis http://purl.obolibrary.org/obo/GO_0090183 GO:0006843 biolink:BiologicalProcess mitochondrial citrate transmembrane transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix. go.json mitochondrial citrate transport http://purl.obolibrary.org/obo/GO_0006843 GO:0031800 biolink:MolecularActivity type 3 metabotropic glutamate receptor binding Binding to a type 3 metabotropic glutamate receptor. go.json type 3 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031800 GO:0006844 biolink:BiologicalProcess acyl carnitine transport The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. go.json http://purl.obolibrary.org/obo/GO_0006844 GO:0090184 biolink:BiologicalProcess positive regulation of kidney development Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json positive regulation of nephrogenesis http://purl.obolibrary.org/obo/GO_0090184 GO:0006841 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006841 GO:0090181 biolink:BiologicalProcess regulation of cholesterol metabolic process Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json http://purl.obolibrary.org/obo/GO_0090181 GO:0090182 biolink:BiologicalProcess regulation of secretion of lysosomal enzymes Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. go.json http://purl.obolibrary.org/obo/GO_0090182 GO:0006842 biolink:BiologicalProcess tricarboxylic acid transport The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006842 GO:0006840 biolink:BiologicalProcess obsolete mitochondrial alpha-ketoglutarate/malate transport OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion. go.json mitochondrial alpha-ketoglutarate/malate transport|mitochondrial oxoglutarate/malate transport True http://purl.obolibrary.org/obo/GO_0006840 GO:0031809 biolink:MolecularActivity H3 histamine receptor binding Binding to a H3 histamine receptor. go.json H3 histamine receptor ligand http://purl.obolibrary.org/obo/GO_0031809 GO:0031807 biolink:MolecularActivity H1 histamine receptor binding Binding to a H1 histamine receptor. go.json H1 histamine receptor ligand http://purl.obolibrary.org/obo/GO_0031807 GO:0031808 biolink:MolecularActivity H2 histamine receptor binding Binding to a H2 histamine receptor. go.json H2 histamine receptor ligand http://purl.obolibrary.org/obo/GO_0031808 GO:0031805 biolink:MolecularActivity type 8 metabotropic glutamate receptor binding Binding to a type 8 metabotropic glutamate receptor. go.json type 8 metabotropic glutamate receptor ligand http://purl.obolibrary.org/obo/GO_0031805 GO:0031806 biolink:MolecularActivity G protein-coupled histamine receptor binding Binding to a G protein-coupled (metabotropic) histamine receptor. go.json G-protein coupled histamine receptor binding|metabotropic histamine receptor binding|metabotropic histamine receptor ligand http://purl.obolibrary.org/obo/GO_0031806 GO:0090187 biolink:BiologicalProcess positive regulation of pancreatic juice secretion Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. go.json http://purl.obolibrary.org/obo/GO_0090187 GO:0090188 biolink:BiologicalProcess negative regulation of pancreatic juice secretion Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. go.json http://purl.obolibrary.org/obo/GO_0090188 GO:0090185 biolink:BiologicalProcess negative regulation of kidney development Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json negative regulation of nephrogenesis http://purl.obolibrary.org/obo/GO_0090185 GO:0090186 biolink:BiologicalProcess regulation of pancreatic juice secretion Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. go.json http://purl.obolibrary.org/obo/GO_0090186 GO:0006849 biolink:BiologicalProcess plasma membrane pyruvate transport The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0006849 GO:0090189 biolink:BiologicalProcess regulation of branching involved in ureteric bud morphogenesis Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. go.json http://purl.obolibrary.org/obo/GO_0090189 GO:0090190 biolink:BiologicalProcess positive regulation of branching involved in ureteric bud morphogenesis Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. go.json http://purl.obolibrary.org/obo/GO_0090190 GO:0006858 biolink:BiologicalProcess extracellular transport The transport of substances that occurs outside cells. go.json http://purl.obolibrary.org/obo/GO_0006858 GO:0006859 biolink:BiologicalProcess obsolete extracellular carbohydrate transport OBSOLETE. The directed extracellular movement of carbohydrates. go.json True http://purl.obolibrary.org/obo/GO_0006859 GO:0090191 biolink:BiologicalProcess negative regulation of branching involved in ureteric bud morphogenesis Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. go.json http://purl.obolibrary.org/obo/GO_0090191 GO:0006856 biolink:BiologicalProcess eye pigment precursor transport The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0006856 GO:0006857 biolink:BiologicalProcess oligopeptide transport The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. go.json http://purl.obolibrary.org/obo/GO_0006857 GO:0006854 biolink:BiologicalProcess obsolete ATP/ADP exchange OBSOLETE. (Was not defined before being made obsolete). go.json ATP/ADP exchange True http://purl.obolibrary.org/obo/GO_0006854 GO:0090194 biolink:BiologicalProcess negative regulation of glomerulus development Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. go.json http://purl.obolibrary.org/obo/GO_0090194 GO:0090195 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090195 GO:0006855 biolink:BiologicalProcess xenobiotic transmembrane transport The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json drug membrane transport|drug transmembrane transport|multidrug transport http://purl.obolibrary.org/obo/GO_0006855 GO:0006852 biolink:BiologicalProcess obsolete mitochondrial sodium/calcium ion exchange OBSOLETE. (Was not defined before being made obsolete). go.json mitochondrial sodium/calcium exchange|mitochondrial sodium/calcium ion exchange True http://purl.obolibrary.org/obo/GO_0006852 GO:0090192 biolink:BiologicalProcess regulation of glomerulus development Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. go.json http://purl.obolibrary.org/obo/GO_0090192 GO:0090193 biolink:BiologicalProcess positive regulation of glomerulus development Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. go.json http://purl.obolibrary.org/obo/GO_0090193 GO:0006853 biolink:BiologicalProcess carnitine shuttle The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine. Wikipedia:Carnitine#Role_in_fatty_acid_metabolism go.json http://purl.obolibrary.org/obo/GO_0006853 GO:0006850 biolink:BiologicalProcess mitochondrial pyruvate transmembrane transport The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json mitochondrial pyruvate transport|pyruvate membrane transport in mitochondria|pyruvate membrane transport in mitochondrion|pyruvate transmembrane transport in mitochondria|pyruvate transmembrane transport in mitochondrion http://purl.obolibrary.org/obo/GO_0006850 GO:0006851 biolink:BiologicalProcess mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json mitochondrial calcium transport http://purl.obolibrary.org/obo/GO_0006851 GO:0090198 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090198 GO:0090199 biolink:BiologicalProcess regulation of release of cytochrome c from mitochondria Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. go.json http://purl.obolibrary.org/obo/GO_0090199 GO:0090196 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090196 GO:0090197 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0090197 GO:0035548 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035548 GO:0035549 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035549 GO:0035540 biolink:BiologicalProcess positive regulation of SNARE complex disassembly Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035540 GO:0035541 biolink:BiologicalProcess negative regulation of SNARE complex disassembly Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035541 GO:0035542 biolink:BiologicalProcess regulation of SNARE complex assembly Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035542 GO:0035543 biolink:BiologicalProcess positive regulation of SNARE complex assembly Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035543 GO:0035544 biolink:BiologicalProcess negative regulation of SNARE complex assembly Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035544 GO:0035545 biolink:BiologicalProcess determination of left/right asymmetry in nervous system The establishment of the nervous system with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0035545 GO:0035546 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035546 GO:0035547 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035547 GO:0035537 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035537 GO:0035538 biolink:MolecularActivity carbohydrate response element binding Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes. go.json ChoRE binding http://purl.obolibrary.org/obo/GO_0035538 GO:0035539 biolink:MolecularActivity 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. EC:3.6.1.55|RHEA:31575|Reactome:R-HSA-2395849|Reactome:R-HSA-2395869|Reactome:R-HSA-9750555 go.json 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity|8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity|8-oxo-dGTP pyrophosphohydrolase activity|8-oxo-dGTPase activity http://purl.obolibrary.org/obo/GO_0035539 GO:0035530 biolink:BiologicalProcess chemokine (C-C motif) ligand 6 production The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL6 production http://purl.obolibrary.org/obo/GO_0035530 gocheck_do_not_annotate GO:0035531 biolink:BiologicalProcess regulation of chemokine (C-C motif) ligand 6 production Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). go.json chemokine (C-C motif) ligand 6 secretion|regulation of CCL6 production|regulation of chemokine (C-C motif) ligand 6 secretion http://purl.obolibrary.org/obo/GO_0035531 GO:0035532 biolink:BiologicalProcess negative regulation of chemokine (C-C motif) ligand 6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). go.json negative regulation of CCL6 production|negative regulation of chemokine (C-C motif) ligand 6 secretion http://purl.obolibrary.org/obo/GO_0035532 GO:0035533 biolink:BiologicalProcess positive regulation of chemokine (C-C motif) ligand 6 production Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). go.json positive regulation of CCL6 production|positive regulation of chemokine (C-C motif) ligand 6 secretion http://purl.obolibrary.org/obo/GO_0035533 GO:0035534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035534 GO:0035535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035535 GO:0035536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035536 GO:0035526 biolink:BiologicalProcess retrograde transport, plasma membrane to Golgi The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles. go.json http://purl.obolibrary.org/obo/GO_0035526 GO:0035527 biolink:MolecularActivity 3-hydroxypropionate dehydrogenase (NADP+) activity Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. EC:1.1.1.298|KEGG_REACTION:R09289|MetaCyc:RXN-8974|RHEA:26438 go.json 3-hydroxypropanoate dehydrogenase (NADP+) activity|3-hydroxypropanoate:NADP+ oxidoreductase|3-hydroxypropionate:NADP+ oxidoreductase http://purl.obolibrary.org/obo/GO_0035527 GO:0035528 biolink:BiologicalProcess obsolete UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis OBSOLETE. The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin. go.json UDP-GlcNAc biosynthesis involved in chitin biosynthesis|UDP-GlcNAc biosynthetic process involved in chitin biosynthesis|UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process|UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis|UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process|UDP-N-acetylglucosamine formation involved in chitin biosynthesis|UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis True http://purl.obolibrary.org/obo/GO_0035528 GO:0035529 biolink:MolecularActivity NADH pyrophosphatase activity Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+. EC:3.6.1.22|KEGG_REACTION:R00103|MetaCyc:RXN0-4401|RHEA:48868|Reactome:R-HSA-6809287 go.json NADH diphosphatase activity|NADH pyrophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0035529 GO:0035520 biolink:BiologicalProcess monoubiquitinated protein deubiquitination The removal of the ubiquitin group from a monoubiquitinated protein. go.json monoubiquitinated protein deubiquitinylation|monoubiquitinated protein deubiquitylation http://purl.obolibrary.org/obo/GO_0035520 GO:0035521 biolink:BiologicalProcess monoubiquitinated histone deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone protein. go.json monoubiquitinated histone deubiquitinylation|monoubiquitinated histone deubiquitylation http://purl.obolibrary.org/obo/GO_0035521 GO:0035522 biolink:BiologicalProcess monoubiquitinated histone H2A deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. go.json monoubiquitinated histone H2A deubiquitinylation|monoubiquitinated histone H2A deubiquitylation http://purl.obolibrary.org/obo/GO_0035522 GO:0035523 biolink:BiologicalProcess protein K29-linked deubiquitination A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein. go.json protein K29-linked deubiquitinylation|protein K29-linked deubiquitylation http://purl.obolibrary.org/obo/GO_0035523 gocheck_do_not_annotate GO:0035524 biolink:BiologicalProcess proline transmembrane transport The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. go.json proline membrane transport http://purl.obolibrary.org/obo/GO_0035524 GO:0035525 biolink:CellularComponent NF-kappaB p50/p65 complex A heterodimer of NF-kappa B p50 and p65 subunits. go.json NF-kappa B1/RelA complex|NF-kappa B1/p65 complex|NF-kappa p105/RelA complex|NF-kappa p105/p65 complex|NF-kappa p50/RelA complex http://purl.obolibrary.org/obo/GO_0035525 GO:0035515 biolink:MolecularActivity oxidative RNA demethylase activity Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. Reactome:R-HSA-8857692 go.json 2-oxoglutarate-dependent RNA demethylase http://purl.obolibrary.org/obo/GO_0035515 GO:0035516 biolink:MolecularActivity oxidative DNA demethylase activity Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. EC:1.14.11.33|MetaCyc:RXN-12353|RHEA:30299 go.json 1-ethyladenine demethylase activity|2-oxoglutarate-dependent DNA demethylase|N1-methyladenine demethylase activity|N3-methylcytosine demethylase activity http://purl.obolibrary.org/obo/GO_0035516 GO:0035517 biolink:CellularComponent PR-DUB complex A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. go.json Polycomb repressive deubiquitinase complex http://purl.obolibrary.org/obo/GO_0035517 GO:0035518 biolink:BiologicalProcess histone H2A monoubiquitination The modification of histone H2A by addition of a single ubiquitin group. go.json http://purl.obolibrary.org/obo/GO_0035518 gocheck_do_not_annotate GO:0035519 biolink:BiologicalProcess protein K29-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation. go.json protein K29-linked polyubiquitination http://purl.obolibrary.org/obo/GO_0035519 GO:0035510 biolink:BiologicalProcess DNA dealkylation The removal of an alkyl group from one or more nucleotides within an DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0035510 GO:0035511 biolink:BiologicalProcess obsolete oxidative DNA demethylation OBSOLETE. Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. go.json True http://purl.obolibrary.org/obo/GO_0035511 GO:0035512 biolink:BiologicalProcess obsolete hydrolytic DNA demethylation OBSOLETE. The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0035512 GO:0035513 biolink:BiologicalProcess oxidative RNA demethylation The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms. go.json http://purl.obolibrary.org/obo/GO_0035513 GO:0035514 biolink:MolecularActivity DNA demethylase activity Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0035514 GO:0035504 biolink:BiologicalProcess regulation of myosin light chain kinase activity Any process that modulates the frequency, rate or extent of myosin light chain kinase activity. go.json http://purl.obolibrary.org/obo/GO_0035504 gocheck_do_not_annotate GO:0035505 biolink:BiologicalProcess positive regulation of myosin light chain kinase activity Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity. go.json http://purl.obolibrary.org/obo/GO_0035505 gocheck_do_not_annotate GO:0035506 biolink:BiologicalProcess negative regulation of myosin light chain kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity. go.json http://purl.obolibrary.org/obo/GO_0035506 gocheck_do_not_annotate GO:0035507 biolink:BiologicalProcess regulation of myosin-light-chain-phosphatase activity Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_0035507 gocheck_do_not_annotate GO:0035508 biolink:BiologicalProcess positive regulation of myosin-light-chain-phosphatase activity Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_0035508 gocheck_do_not_annotate GO:0035509 biolink:BiologicalProcess negative regulation of myosin-light-chain-phosphatase activity Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_0035509 gocheck_do_not_annotate GO:0035500 biolink:MolecularActivity MH2 domain binding Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. go.json MAD homology 2 domain binding http://purl.obolibrary.org/obo/GO_0035500 GO:0035501 biolink:MolecularActivity MH1 domain binding Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors. go.json MAD homology 1 domain binding http://purl.obolibrary.org/obo/GO_0035501 GO:0035502 biolink:BiologicalProcess metanephric part of ureteric bud development The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0035502 GO:0035503 biolink:BiologicalProcess ureter part of ureteric bud development The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter. go.json http://purl.obolibrary.org/obo/GO_0035503 GO:1901569 biolink:BiologicalProcess fatty acid derivative catabolic process The chemical reactions and pathways resulting in the breakdown of fatty acid derivative. go.json fatty acid derivative breakdown|fatty acid derivative catabolism|fatty acid derivative degradation http://purl.obolibrary.org/obo/GO_1901569 GO:1901567 biolink:MolecularActivity fatty acid derivative binding Binding to fatty acid derivative. go.json http://purl.obolibrary.org/obo/GO_1901567 GO:1901568 biolink:BiologicalProcess fatty acid derivative metabolic process The chemical reactions and pathways involving fatty acid derivative. go.json fatty acid derivative metabolism http://purl.obolibrary.org/obo/GO_1901568 GO:1901565 biolink:BiologicalProcess organonitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. go.json organonitrogen compound breakdown|organonitrogen compound catabolism|organonitrogen compound degradation http://purl.obolibrary.org/obo/GO_1901565 GO:1901566 biolink:BiologicalProcess organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organonitrogen compound. go.json organonitrogen compound anabolism|organonitrogen compound biosynthesis|organonitrogen compound formation|organonitrogen compound synthesis http://purl.obolibrary.org/obo/GO_1901566 GO:0060470 biolink:BiologicalProcess positive regulation of cytosolic calcium ion concentration involved in egg activation The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg. go.json elevation of cytosolic calcium ion concentration involved in egg activation http://purl.obolibrary.org/obo/GO_0060470 GO:1901563 biolink:BiologicalProcess response to camptothecin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus. go.json response to CPT http://purl.obolibrary.org/obo/GO_1901563 GO:0060471 biolink:BiologicalProcess cortical granule exocytosis The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy. go.json cortical granule release|cortical reaction http://purl.obolibrary.org/obo/GO_0060471 GO:1901564 biolink:BiologicalProcess organonitrogen compound metabolic process The chemical reactions and pathways involving organonitrogen compound. go.json organonitrogen compound metabolism http://purl.obolibrary.org/obo/GO_1901564 GO:0060472 biolink:BiologicalProcess positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol. go.json positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_0060472 GO:1901561 biolink:BiologicalProcess obsolete response to benomyl OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus. go.json True http://purl.obolibrary.org/obo/GO_1901561 GO:1901562 biolink:BiologicalProcess response to paraquat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. go.json http://purl.obolibrary.org/obo/GO_1901562 GO:0060473 biolink:CellularComponent cortical granule A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. go.json cortical vesicle http://purl.obolibrary.org/obo/GO_0060473 GO:0060474 biolink:BiologicalProcess positive regulation of flagellated sperm motility involved in capacitation The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence. go.json positive regulation of sperm motility involved in capacitation http://purl.obolibrary.org/obo/GO_0060474 GO:1901570 biolink:BiologicalProcess fatty acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acid derivative. go.json fatty acid derivative anabolism|fatty acid derivative biosynthesis|fatty acid derivative formation|fatty acid derivative synthesis http://purl.obolibrary.org/obo/GO_1901570 GO:0060475 biolink:BiologicalProcess obsolete positive regulation of actin filament polymerization involved in acrosome reaction OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction. go.json positive regulation of actin polymerization involved in acrosome reaction True http://purl.obolibrary.org/obo/GO_0060475 GO:1901571 biolink:BiologicalProcess fatty acid derivative transport The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901571 GO:0060476 biolink:BiologicalProcess protein localization involved in acrosome reaction The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction. go.json protein localisation involved in acrosome reaction http://purl.obolibrary.org/obo/GO_0060476 GO:0060477 biolink:BiologicalProcess obsolete peptidyl-serine phosphorylation involved in acrosome reaction OBSOLETE. The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction. go.json True http://purl.obolibrary.org/obo/GO_0060477 GO:0060478 biolink:BiologicalProcess acrosomal vesicle exocytosis The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction. go.json acrosomal granule exocytosis|acrosome exocytosis http://purl.obolibrary.org/obo/GO_0060478 GO:0060479 biolink:BiologicalProcess lung cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json pulmonary cell differentiation http://purl.obolibrary.org/obo/GO_0060479 GO:1901578 biolink:BiologicalProcess negative regulation of alkane biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of alkane biosynthetic process. go.json down regulation of alkane anabolism|down regulation of alkane biosynthesis|down regulation of alkane biosynthetic process|down regulation of alkane formation|down regulation of alkane synthesis|down-regulation of alkane anabolism|down-regulation of alkane biosynthesis|down-regulation of alkane biosynthetic process|down-regulation of alkane formation|down-regulation of alkane synthesis|downregulation of alkane anabolism|downregulation of alkane biosynthesis|downregulation of alkane biosynthetic process|downregulation of alkane formation|downregulation of alkane synthesis|inhibition of alkane anabolism|inhibition of alkane biosynthesis|inhibition of alkane biosynthetic process|inhibition of alkane formation|inhibition of alkane synthesis|negative regulation of alkane anabolism|negative regulation of alkane biosynthesis|negative regulation of alkane formation|negative regulation of alkane synthesis http://purl.obolibrary.org/obo/GO_1901578 GO:1901579 biolink:BiologicalProcess positive regulation of alkane biosynthetic process Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process. go.json activation of alkane anabolism|activation of alkane biosynthesis|activation of alkane biosynthetic process|activation of alkane formation|activation of alkane synthesis|positive regulation of alkane anabolism|positive regulation of alkane biosynthesis|positive regulation of alkane formation|positive regulation of alkane synthesis|up regulation of alkane anabolism|up regulation of alkane biosynthesis|up regulation of alkane biosynthetic process|up regulation of alkane formation|up regulation of alkane synthesis|up-regulation of alkane anabolism|up-regulation of alkane biosynthesis|up-regulation of alkane biosynthetic process|up-regulation of alkane formation|up-regulation of alkane synthesis|upregulation of alkane anabolism|upregulation of alkane biosynthesis|upregulation of alkane biosynthetic process|upregulation of alkane formation|upregulation of alkane synthesis http://purl.obolibrary.org/obo/GO_1901579 GO:1901576 biolink:BiologicalProcess organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. go.json organic molecular entity anabolism|organic molecular entity biosynthesis|organic molecular entity biosynthetic process|organic molecular entity formation|organic molecular entity synthesis|organic substance anabolism|organic substance biosynthesis|organic substance formation|organic substance synthesis http://purl.obolibrary.org/obo/GO_1901576 GO:1901577 biolink:BiologicalProcess regulation of alkane biosynthetic process Any process that modulates the frequency, rate or extent of alkane biosynthetic process. go.json regulation of alkane anabolism|regulation of alkane biosynthesis|regulation of alkane formation|regulation of alkane synthesis http://purl.obolibrary.org/obo/GO_1901577 GO:1901574 biolink:BiologicalProcess obsolete chemical substance biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of chemical substance. go.json chemical substance anabolism|chemical substance biosynthesis|chemical substance biosynthetic process|chemical substance formation|chemical substance synthesis True http://purl.obolibrary.org/obo/GO_1901574 GO:1901575 biolink:BiologicalProcess organic substance catabolic process The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. go.json organic molecular entity breakdown|organic molecular entity catabolic process|organic molecular entity catabolism|organic molecular entity degradation|organic substance breakdown|organic substance catabolism|organic substance degradation http://purl.obolibrary.org/obo/GO_1901575 GO:0060460 biolink:BiologicalProcess left lung morphogenesis The process in which anatomical structures of the left lung are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060460 GO:1901572 biolink:BiologicalProcess obsolete chemical substance metabolic process OBSOLETE. The chemical reactions and pathways involving chemical substance. go.json chemical substance metabolic process|chemical substance metabolism True http://purl.obolibrary.org/obo/GO_1901572 GO:0060461 biolink:BiologicalProcess right lung morphogenesis The process in which anatomical structures of the right lung are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060461 GO:1901573 biolink:BiologicalProcess obsolete chemical substance catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chemical substance. go.json chemical substance breakdown|chemical substance catabolic process|chemical substance catabolism|chemical substance degradation True http://purl.obolibrary.org/obo/GO_1901573 GO:0060462 biolink:BiologicalProcess lung lobe development The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. go.json http://purl.obolibrary.org/obo/GO_0060462 GO:1901581 biolink:BiologicalProcess obsolete negative regulation of telomeric RNA transcription from RNA pol II promoter OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter. go.json down regulation of telomeric RNA transcription from Pol II promoter|down regulation of telomeric RNA transcription from RNA pol II promoter|down-regulation of telomeric RNA transcription from Pol II promoter|down-regulation of telomeric RNA transcription from RNA pol II promoter|downregulation of telomeric RNA transcription from Pol II promoter|downregulation of telomeric RNA transcription from RNA pol II promoter|inhibition of telomeric RNA transcription from Pol II promoter|inhibition of telomeric RNA transcription from RNA pol II promoter|negative regulation of telomeric RNA transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_1901581 GO:0060463 biolink:BiologicalProcess lung lobe morphogenesis The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. go.json http://purl.obolibrary.org/obo/GO_0060463 GO:0035496 biolink:MolecularActivity lipopolysaccharide-1,5-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide. go.json LPS-1,5-galactosyltransferase activity|UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase http://purl.obolibrary.org/obo/GO_0035496 GO:0035497 biolink:MolecularActivity cAMP response element binding Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. go.json CRE binding|cAMP-responsive element binding|cyclic AMP response element binding|cyclic-AMP response element binding|cyclic-AMP-responsive element binding http://purl.obolibrary.org/obo/GO_0035497 GO:1901582 biolink:BiologicalProcess obsolete positive regulation of telomeric RNA transcription from RNA pol II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter. go.json activation of telomeric RNA transcription from Pol II promoter|activation of telomeric RNA transcription from RNA pol II promoter|positive regulation of telomeric RNA transcription from Pol II promoter|up regulation of telomeric RNA transcription from Pol II promoter|up regulation of telomeric RNA transcription from RNA pol II promoter|up-regulation of telomeric RNA transcription from Pol II promoter|up-regulation of telomeric RNA transcription from RNA pol II promoter|upregulation of telomeric RNA transcription from Pol II promoter|upregulation of telomeric RNA transcription from RNA pol II promoter True http://purl.obolibrary.org/obo/GO_1901582 GO:0060464 biolink:BiologicalProcess lung lobe formation The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. go.json http://purl.obolibrary.org/obo/GO_0060464 GO:0060465 biolink:BiologicalProcess pharynx development The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. go.json pharyngeal development http://purl.obolibrary.org/obo/GO_0060465 GO:0035498 biolink:BiologicalProcess carnosine metabolic process The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine). go.json carnosine metabolism http://purl.obolibrary.org/obo/GO_0035498 GO:1901580 biolink:BiologicalProcess obsolete regulation of telomeric RNA transcription from RNA pol II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter. go.json regulation of telomeric RNA transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_1901580 GO:0060466 biolink:BiologicalProcess activation of meiosis involved in egg activation Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation. go.json reactivation of meiosis after fertilization|resumption of meiosis involved in egg activation http://purl.obolibrary.org/obo/GO_0060466 GO:0035499 biolink:BiologicalProcess carnosine biosynthetic process The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine). go.json carnosine anabolism|carnosine biosynthesis|carnosine formation|carnosine synthesis http://purl.obolibrary.org/obo/GO_0035499 GO:0060467 biolink:BiologicalProcess negative regulation of fertilization Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). go.json http://purl.obolibrary.org/obo/GO_0060467 GO:0060468 biolink:BiologicalProcess prevention of polyspermy The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. go.json negative regulation of fertilization involved in egg activation|polyspermy block http://purl.obolibrary.org/obo/GO_0060468 GO:0060469 biolink:BiologicalProcess obsolete positive regulation of transcription involved in egg activation OBSOLETE. Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation. go.json activation of the egg genome|activation of the maternal genome True http://purl.obolibrary.org/obo/GO_0060469 GO:0035490 biolink:BiologicalProcess regulation of leukotriene production involved in inflammatory response Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0035490 GO:0035491 biolink:BiologicalProcess positive regulation of leukotriene production involved in inflammatory response Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0035491 GO:0035492 biolink:BiologicalProcess negative regulation of leukotriene production involved in inflammatory response Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0035492 GO:0035493 biolink:BiologicalProcess SNARE complex assembly The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035493 GO:0035494 biolink:BiologicalProcess SNARE complex disassembly The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035494 GO:0035495 biolink:BiologicalProcess regulation of SNARE complex disassembly Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. go.json http://purl.obolibrary.org/obo/GO_0035495 GO:1901589 biolink:CellularComponent axon microtubule bundle An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment. NIF_Subcellular:sao707332678 go.json axon microtubule fascicle|microtubule bundle of axon|microtubule fascicle of axon http://purl.obolibrary.org/obo/GO_1901589 GO:1901587 biolink:BiologicalProcess positive regulation of acid-sensing ion channel activity Any process that activates or increases the frequency, rate or extent of acid-sensing ion channel activity. go.json activation of ASIC activity|activation of acid-sensing ion channel activity|positive regulation of ASIC activity|up regulation of ASIC activity|up regulation of acid-sensing ion channel activity|up-regulation of ASIC activity|up-regulation of acid-sensing ion channel activity|upregulation of ASIC activity|upregulation of acid-sensing ion channel activity http://purl.obolibrary.org/obo/GO_1901587 gocheck_do_not_annotate GO:0060490 biolink:BiologicalProcess lateral sprouting involved in lung morphogenesis The process in which a branch forms along the side of the lung epithelial tube. go.json http://purl.obolibrary.org/obo/GO_0060490 GO:0060491 biolink:BiologicalProcess regulation of cell projection assembly Any process that modulates the rate, frequency, or extent of cell projection assembly. go.json regulation of cell projection formation http://purl.obolibrary.org/obo/GO_0060491 GO:1901588 biolink:CellularComponent dendritic microtubule Any microtubule in a dendrite, a neuron projection. NIF_Subcellular:sao110773650 go.json microtubule of dendrite|microtubulus of dendrite http://purl.obolibrary.org/obo/GO_1901588 GO:1901585 biolink:BiologicalProcess regulation of acid-sensing ion channel activity Any process that modulates the frequency, rate or extent of acid-sensing ion channel activity. go.json regulation of ASIC activity http://purl.obolibrary.org/obo/GO_1901585 gocheck_do_not_annotate GO:0060492 biolink:BiologicalProcess lung induction The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung. go.json http://purl.obolibrary.org/obo/GO_0060492 GO:1901586 biolink:BiologicalProcess negative regulation of acid-sensing ion channel activity Any process that stops, prevents or reduces the frequency, rate or extent of acid-sensing ion channel activity. go.json down regulation of ASIC activity|down regulation of acid-sensing ion channel activity|down-regulation of ASIC activity|down-regulation of acid-sensing ion channel activity|downregulation of ASIC activity|downregulation of acid-sensing ion channel activity|inhibition of ASIC activity|inhibition of acid-sensing ion channel activity|negative regulation of ASIC activity http://purl.obolibrary.org/obo/GO_1901586 gocheck_do_not_annotate GO:0060493 biolink:BiologicalProcess mesenchymal-endodermal cell signaling involved in lung induction Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud. go.json mesenchymal-endodermal cell signalling involved in lung induction http://purl.obolibrary.org/obo/GO_0060493 GO:1901583 biolink:BiologicalProcess tetrapeptide import across plasma membrane The directed movement of a tetrapeptide from outside of a cell, across the plasma membrane and into the cytosol. go.json tetrapeptide membrane transport|tetrapeptide transmembrane transport http://purl.obolibrary.org/obo/GO_1901583 GO:0060494 biolink:BiologicalProcess inductive mesenchymal-endodermal cell signaling Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell. go.json inductive mesenchymal-endodermal cell signalling http://purl.obolibrary.org/obo/GO_0060494 GO:0060495 biolink:BiologicalProcess cell-cell signaling involved in lung development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. go.json cell-cell signalling involved in lung development http://purl.obolibrary.org/obo/GO_0060495 GO:1901584 biolink:MolecularActivity tetrapeptide transmembrane transporter activity Enables the transfer of tetrapeptide from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901584 GO:1901592 biolink:BiologicalProcess negative regulation of double-strand break repair via break-induced replication Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication. go.json down regulation of double-strand break repair via break-induced replication|down-regulation of double-strand break repair via break-induced replication|downregulation of double-strand break repair via break-induced replication|inhibition of double-strand break repair via break-induced replication http://purl.obolibrary.org/obo/GO_1901592 GO:0060496 biolink:BiologicalProcess mesenchymal-epithelial cell signaling involved in lung development Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. go.json mesenchymal-epithelial cell signalling involved in lung development http://purl.obolibrary.org/obo/GO_0060496 GO:0035485 biolink:MolecularActivity adenine/guanine mispair binding Binding to a double-stranded DNA region containing an A/G mispair. go.json A/G mispair binding|G/A mispair binding|guanine-adenine mispair binding http://purl.obolibrary.org/obo/GO_0035485 GO:1901593 biolink:BiologicalProcess response to GW 7647 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus. go.json http://purl.obolibrary.org/obo/GO_1901593 GO:0060497 biolink:BiologicalProcess mesenchymal-endodermal cell signaling Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. go.json mesenchymal-endodermal cell signalling http://purl.obolibrary.org/obo/GO_0060497 GO:0035486 biolink:MolecularActivity cytosine/cytosine mispair binding Binding to a double-stranded DNA region containing a C/C mispair. go.json C/C mispair binding http://purl.obolibrary.org/obo/GO_0035486 GO:0060498 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in lung bud formation The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud. go.json retinoic acid receptor signalling pathway involved in lung bud formation http://purl.obolibrary.org/obo/GO_0060498 GO:0035487 biolink:MolecularActivity thymine/thymine mispair binding Binding to a double-stranded DNA region containing a T/T mispair. go.json T/T mispair binding http://purl.obolibrary.org/obo/GO_0035487 GO:1901591 biolink:BiologicalProcess regulation of double-strand break repair via break-induced replication Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication. go.json http://purl.obolibrary.org/obo/GO_1901591 GO:0060499 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in lung induction The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus. go.json fibroblast growth factor receptor signalling pathway involved in lung induction http://purl.obolibrary.org/obo/GO_0060499 GO:0035488 biolink:MolecularActivity cytosine/thymine mispair binding Binding to a double-stranded DNA region containing a C/T mispair. go.json C/T mispair binding|T/C mispair binding|thymine/cytosine mispair binding http://purl.obolibrary.org/obo/GO_0035488 GO:0035489 biolink:MolecularActivity guanine/guanine mispair binding Binding to a double-stranded DNA region containing a G/G mispair. go.json G/G mispair binding http://purl.obolibrary.org/obo/GO_0035489 GO:0035480 biolink:BiologicalProcess regulation of Notch signaling pathway involved in heart induction Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. go.json regulation of Notch signalling pathway involved in heart induction http://purl.obolibrary.org/obo/GO_0035480 GO:0035481 biolink:BiologicalProcess positive regulation of Notch signaling pathway involved in heart induction Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. go.json positive regulation of Notch signalling pathway involved in heart induction http://purl.obolibrary.org/obo/GO_0035481 GO:0035482 biolink:BiologicalProcess gastric motility The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum. go.json http://purl.obolibrary.org/obo/GO_0035482 GO:0035483 biolink:BiologicalProcess gastric emptying The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. go.json http://purl.obolibrary.org/obo/GO_0035483 GO:0035484 biolink:MolecularActivity adenine/adenine mispair binding Binding to a double-stranded DNA region containing an A/A mispair. go.json A/A mispair binding http://purl.obolibrary.org/obo/GO_0035484 GO:1901598 biolink:BiologicalProcess (-)-pinoresinol metabolic process The chemical reactions and pathways involving (-)-pinoresinol. go.json (-)-pinoresinol metabolism http://purl.obolibrary.org/obo/GO_1901598 GO:0060480 biolink:BiologicalProcess lung goblet cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins. go.json pulmonary goblet cell differentiation http://purl.obolibrary.org/obo/GO_0060480 GO:1901599 biolink:BiologicalProcess (-)-pinoresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-pinoresinol. go.json (-)-pinoresinol anabolism|(-)-pinoresinol biosynthesis|(-)-pinoresinol formation|(-)-pinoresinol synthesis http://purl.obolibrary.org/obo/GO_1901599 GO:1901596 biolink:BiologicalProcess response to reversine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. go.json http://purl.obolibrary.org/obo/GO_1901596 GO:0060481 biolink:BiologicalProcess lobar bronchus epithelium development The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus. go.json http://purl.obolibrary.org/obo/GO_0060481 GO:1901597 biolink:BiologicalProcess response to carbendazim Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus. go.json http://purl.obolibrary.org/obo/GO_1901597 GO:0060482 biolink:BiologicalProcess lobar bronchus development The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi. go.json http://purl.obolibrary.org/obo/GO_0060482 GO:1901594 biolink:BiologicalProcess response to capsazepine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. go.json http://purl.obolibrary.org/obo/GO_1901594 GO:0060483 biolink:BiologicalProcess lobar bronchus mesenchyme development The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus. go.json http://purl.obolibrary.org/obo/GO_0060483 GO:1901595 biolink:BiologicalProcess response to hesperadin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901595 GO:0060484 biolink:BiologicalProcess lung-associated mesenchyme development The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung. go.json lung mesenchyme development|pulmonary mesenchyme development http://purl.obolibrary.org/obo/GO_0060484 GO:0035474 biolink:BiologicalProcess selective angioblast sprouting The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel. go.json http://purl.obolibrary.org/obo/GO_0035474 GO:0060485 biolink:BiologicalProcess mesenchyme development The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. go.json mesenchymal development http://purl.obolibrary.org/obo/GO_0060485 GO:0035475 biolink:BiologicalProcess angioblast cell migration involved in selective angioblast sprouting The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations. go.json http://purl.obolibrary.org/obo/GO_0035475 GO:0060486 biolink:BiologicalProcess club cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. go.json Clara cell differentiation http://purl.obolibrary.org/obo/GO_0060486 GO:0035476 biolink:BiologicalProcess angioblast cell migration The orderly movement of angioblasts, cells involved in blood vessel morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0035476 GO:0060487 biolink:BiologicalProcess lung epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. go.json pulmonary epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0060487 GO:0035477 biolink:BiologicalProcess regulation of angioblast cell migration involved in selective angioblast sprouting Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting. go.json http://purl.obolibrary.org/obo/GO_0035477 GO:0060488 biolink:BiologicalProcess orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis The process in which a lung bud bifurcates perpendicular to the plane of the previous bud. go.json perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis http://purl.obolibrary.org/obo/GO_0060488 GO:0060489 biolink:BiologicalProcess planar dichotomous subdivision of terminal units involved in lung branching morphogenesis The process in which a lung bud bifurcates parallel to the plane of the previous bud. go.json http://purl.obolibrary.org/obo/GO_0060489 GO:0035478 biolink:MolecularActivity chylomicron binding Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. go.json http://purl.obolibrary.org/obo/GO_0035478 GO:0035479 biolink:BiologicalProcess angioblast cell migration from lateral mesoderm to midline The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature. go.json http://purl.obolibrary.org/obo/GO_0035479 GO:0035470 biolink:BiologicalProcess positive regulation of vascular wound healing Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. go.json http://purl.obolibrary.org/obo/GO_0035470 GO:0035471 biolink:BiologicalProcess luteinizing hormone signaling pathway involved in ovarian follicle development The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure. go.json luteinizing hormone signalling pathway involved in ovarian follicle development http://purl.obolibrary.org/obo/GO_0035471 GO:0035472 biolink:MolecularActivity choriogonadotropin hormone receptor activity Combining with the choriogonadotropin hormone to initiate a change in cell activity. go.json CG receptor activity|chorio-gonadotrophin receptor activity|chorionic gonadotropin hormone receptor http://purl.obolibrary.org/obo/GO_0035472 GO:0035473 biolink:MolecularActivity lipase binding Binding to a lipase. go.json http://purl.obolibrary.org/obo/GO_0035473 GO:0035463 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves. go.json TGF-beta receptor signaling pathway involved in determination of left/right asymmetry|TGF-beta receptor signalling pathway involved in determination of left/right asymmetry|TGFbeta receptor signaling pathway involved in determination of left/right asymmetry|TGFbeta receptor signalling pathway involved in determination of left/right asymmetry|transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry True http://purl.obolibrary.org/obo/GO_0035463 GO:0035464 biolink:BiologicalProcess obsolete regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves. go.json regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry|regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry|regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry|regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry|regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry True http://purl.obolibrary.org/obo/GO_0035464 GO:0035465 biolink:BiologicalProcess obsolete regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves. go.json regulation of TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_0035465 GO:0035466 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035466 GO:0035467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035467 GO:0035468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035468 GO:0035469 biolink:BiologicalProcess determination of pancreatic left/right asymmetry Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. go.json http://purl.obolibrary.org/obo/GO_0035469 GO:0035460 biolink:MolecularActivity L-ascorbate 6-phosphate lactonase activity Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate. RHEA:28803 go.json http://purl.obolibrary.org/obo/GO_0035460 GO:0035461 biolink:BiologicalProcess vitamin transmembrane transport The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json vitamin membrane transport http://purl.obolibrary.org/obo/GO_0035461 GO:0035462 biolink:BiologicalProcess determination of left/right asymmetry in diencephalon The establishment of the diencephalon with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0035462 GO:0035452 biolink:CellularComponent extrinsic component of plastid membrane The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to plastid membrane|peripheral to plastid membrane http://purl.obolibrary.org/obo/GO_0035452 GO:0035453 biolink:CellularComponent extrinsic component of plastid inner membrane The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to plastid inner membrane|peripheral to plastid inner membrane http://purl.obolibrary.org/obo/GO_0035453 GO:0035454 biolink:CellularComponent extrinsic component of stromal side of plastid inner membrane The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. go.json extrinsic to stromal leaflet of plastid inner membrane|extrinsic to stromal side of plastid inner membrane|peripheral to stromal side of plastid inner membrane http://purl.obolibrary.org/obo/GO_0035454 GO:0035455 biolink:BiologicalProcess response to interferon-alpha Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. go.json response to interferon alfa-n1|response to interferon alfa-n3|response to leukocyte interferon|response to lymphoblast interferon|response to lymphoblastoid interferon http://purl.obolibrary.org/obo/GO_0035455 GO:0035456 biolink:BiologicalProcess response to interferon-beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. go.json response to beta-1 interferon|response to fiblaferon|response to fibroblast interferon|response to interferon beta http://purl.obolibrary.org/obo/GO_0035456 GO:0035457 biolink:BiologicalProcess cellular response to interferon-alpha Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. go.json cellular response to interferon alfa-n1|cellular response to interferon alfa-n3|cellular response to leukocyte interferon|cellular response to lymphoblast interferon|cellular response to lymphoblastoid interferon http://purl.obolibrary.org/obo/GO_0035457 GO:0035458 biolink:BiologicalProcess cellular response to interferon-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. go.json cellular response to beta-1 interferon|cellular response to fiblaferon|cellular response to fibroblast interferon http://purl.obolibrary.org/obo/GO_0035458 GO:0035459 biolink:BiologicalProcess vesicle cargo loading The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle. go.json cargo loading into vesicle|cargo selection http://purl.obolibrary.org/obo/GO_0035459 GO:0035450 biolink:CellularComponent extrinsic component of lumenal side of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region. go.json extrinsic to lumenal leaflet of plastid thylakoid membrane|extrinsic to lumenal side of plastid thylakoid membrane|peripheral to lumenal side of plastid thylakoid membrane http://purl.obolibrary.org/obo/GO_0035450 GO:0035451 biolink:CellularComponent extrinsic component of stromal side of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. go.json extrinsic to stromal leaflet of plastid thylakoid membrane|extrinsic to stromal side of plastid thylakoid membrane|peripheral to stromal side of plastid thylakoid membrane http://purl.obolibrary.org/obo/GO_0035451 GO:0035449 biolink:CellularComponent extrinsic component of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to plastid thylakoid membrane|peripheral to plastid thylakoid membrane http://purl.obolibrary.org/obo/GO_0035449 GO:0035441 biolink:BiologicalProcess cell migration involved in vasculogenesis The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. go.json http://purl.obolibrary.org/obo/GO_0035441 GO:0035442 biolink:BiologicalProcess dipeptide transmembrane transport The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. go.json dipeptide membrane transport http://purl.obolibrary.org/obo/GO_0035442 GO:0035443 biolink:BiologicalProcess tripeptide transmembrane transport The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds. go.json tripeptide membrane transport http://purl.obolibrary.org/obo/GO_0035443 GO:0035444 biolink:BiologicalProcess nickel cation transmembrane transport The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. go.json nickel cation membrane transport http://purl.obolibrary.org/obo/GO_0035444 GO:0035445 biolink:BiologicalProcess borate transmembrane transport The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. go.json borate membrane transport|boron transmembrane transport http://purl.obolibrary.org/obo/GO_0035445 GO:0035446 biolink:MolecularActivity cysteine-glucosaminylinositol ligase activity Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins. EC:6.3.1.13|MetaCyc:RXN1G-4|RHEA:26176 go.json L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase|MshC ligase|desacetylmycothiol synthase http://purl.obolibrary.org/obo/GO_0035446 GO:0035447 biolink:MolecularActivity mycothiol synthase activity Catalysis of the reaction: 1D-myo-inositol-2-(L-cysteinylamido)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coA + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol. EC:2.3.1.189|MetaCyc:RXN1G-4|RHEA:26172 go.json acetyl-CoA:Cys-GlcN-Ins acetyltransferase http://purl.obolibrary.org/obo/GO_0035447 GO:0035448 biolink:CellularComponent extrinsic component of thylakoid membrane The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to thylakoid membrane|peripheral to thylakoid membrane http://purl.obolibrary.org/obo/GO_0035448 GO:0035440 biolink:BiologicalProcess tuberculosinol biosynthetic process The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria. MetaCyc:PWY-5935 go.json halima-5,6,dien-15-ol biosynthesis|halima-5,6,dien-15-ol biosynthetic process|tuberculosinol biosynthesis http://purl.obolibrary.org/obo/GO_0035440 GO:0035438 biolink:MolecularActivity cyclic-di-GMP binding Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. go.json 3',5'-cyclic di-GMP binding|c-di-GMP binding|cyclic dinucleotide di-GMP binding http://purl.obolibrary.org/obo/GO_0035438 GO:0035439 biolink:MolecularActivity halimadienyl-diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate. EC:5.5.1.16|RHEA:25621 go.json halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)|halimadienyl diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0035439 GO:0035430 biolink:BiologicalProcess regulation of gluconate transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore. go.json regulation of gluconate membrane transport|regulation of gluconate transport http://purl.obolibrary.org/obo/GO_0035430 GO:0035431 biolink:BiologicalProcess negative regulation of gluconate transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. go.json down regulation of gluconate transport|down-regulation of gluconate transport|downregulation of gluconate transport|inhibition of gluconate transport|negative regulation of gluconate membrane transport|negative regulation of gluconate transport http://purl.obolibrary.org/obo/GO_0035431 GO:0035432 biolink:BiologicalProcess positive regulation of gluconate transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. go.json activation of gluconate transport|induction of gluconate transport|positive regulation of gluconate membrane transport|positive regulation of gluconate transport|stimulation of gluconate transport|up regulation of gluconate transport|up-regulation of gluconate transport|upregulation of gluconate transport http://purl.obolibrary.org/obo/GO_0035432 GO:0035433 biolink:BiologicalProcess acetate transmembrane transport The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid. go.json acetate membrane transport http://purl.obolibrary.org/obo/GO_0035433 GO:0035434 biolink:BiologicalProcess copper ion transmembrane transport The directed movement of copper cation across a membrane. go.json copper cation transmembrane transport|copper ion membrane transport http://purl.obolibrary.org/obo/GO_0035434 GO:0035435 biolink:BiologicalProcess phosphate ion transmembrane transport The process in which a phosphate is transported across a membrane. go.json phosphate ion membrane transport http://purl.obolibrary.org/obo/GO_0035435 GO:0035436 biolink:BiologicalProcess triose phosphate transmembrane transport The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester. go.json triose phosphate membrane transport http://purl.obolibrary.org/obo/GO_0035436 GO:0035437 biolink:BiologicalProcess maintenance of protein localization in endoplasmic reticulum Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. go.json maintenance of protein localisation in endoplasmic reticulum|maintenance of protein localization in ER|maintenance of protein location in ER|maintenance of protein location in endoplasmic reticulum|protein-ER retention|protein-endoplasmic reticulum retention|retention of protein in ER|retention of protein in endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0035437 GO:1901509 biolink:BiologicalProcess regulation of endothelial tube morphogenesis Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1901509 GO:1901507 biolink:BiologicalProcess negative regulation of acylglycerol transport Any process that stops, prevents or reduces the frequency, rate or extent of acylglycerol transport. go.json down regulation of acylglycerol transport|down regulation of glyceride transport|down-regulation of acylglycerol transport|down-regulation of glyceride transport|downregulation of acylglycerol transport|downregulation of glyceride transport|inhibition of acylglycerol transport|inhibition of glyceride transport|negative regulation of glyceride transport http://purl.obolibrary.org/obo/GO_1901507 GO:1901508 biolink:BiologicalProcess positive regulation of acylglycerol transport Any process that activates or increases the frequency, rate or extent of acylglycerol transport. go.json activation of acylglycerol transport|activation of glyceride transport|positive regulation of glyceride transport|up regulation of acylglycerol transport|up regulation of glyceride transport|up-regulation of acylglycerol transport|up-regulation of glyceride transport|upregulation of acylglycerol transport|upregulation of glyceride transport http://purl.obolibrary.org/obo/GO_1901508 GO:1901505 biolink:MolecularActivity carbohydrate derivative transmembrane transporter activity Enables the transfer of carbohydrate derivative from one side of a membrane to the other. go.json carbohydrate derivative transporter activity http://purl.obolibrary.org/obo/GO_1901505 GO:1901506 biolink:BiologicalProcess regulation of acylglycerol transport Any process that modulates the frequency, rate or extent of acylglycerol transport. go.json regulation of glyceride transport http://purl.obolibrary.org/obo/GO_1901506 GO:1901503 biolink:BiologicalProcess ether biosynthetic process The chemical reactions and pathways resulting in the formation of ether. go.json ether anabolism|ether biosynthesis|ether formation|ether synthesis http://purl.obolibrary.org/obo/GO_1901503 GO:1901504 biolink:BiologicalProcess triazole transport The directed movement of a triazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901504 GO:1901501 biolink:BiologicalProcess response to xylene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xylene stimulus. go.json http://purl.obolibrary.org/obo/GO_1901501 GO:1901502 biolink:BiologicalProcess ether catabolic process The chemical reactions and pathways resulting in the breakdown of ether. go.json ether breakdown|ether catabolism|ether degradation http://purl.obolibrary.org/obo/GO_1901502 GO:1901500 biolink:BiologicalProcess response to p-xylene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a p-xylene stimulus. go.json http://purl.obolibrary.org/obo/GO_1901500 GO:0060410 biolink:BiologicalProcess negative regulation of acetylcholine metabolic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. go.json http://purl.obolibrary.org/obo/GO_0060410 GO:0060411 biolink:BiologicalProcess cardiac septum morphogenesis The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. go.json heart septum morphogenesis http://purl.obolibrary.org/obo/GO_0060411 GO:0060412 biolink:BiologicalProcess ventricular septum morphogenesis The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. go.json interventricular septum morphogenesis http://purl.obolibrary.org/obo/GO_0060412 GO:0060413 biolink:BiologicalProcess atrial septum morphogenesis The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. go.json interatrial septum morphogenesis http://purl.obolibrary.org/obo/GO_0060413 GO:0060414 biolink:BiologicalProcess aorta smooth muscle tissue morphogenesis The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. go.json http://purl.obolibrary.org/obo/GO_0060414 GO:0060415 biolink:BiologicalProcess muscle tissue morphogenesis The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. go.json http://purl.obolibrary.org/obo/GO_0060415 GO:0060416 biolink:BiologicalProcess response to growth hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. go.json response to growth hormone stimulus http://purl.obolibrary.org/obo/GO_0060416 GO:0060417 biolink:CellularComponent yolk The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo. go.json http://purl.obolibrary.org/obo/GO_0060417 GO:0060418 biolink:CellularComponent yolk plasma Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed. go.json http://purl.obolibrary.org/obo/GO_0060418 GO:0060419 biolink:BiologicalProcess heart growth The increase in size or mass of the heart. go.json http://purl.obolibrary.org/obo/GO_0060419 GO:1901518 biolink:BiologicalProcess aspyridone A biosynthetic process The chemical reactions and pathways resulting in the formation of aspyridone A. go.json aspyridone A anabolism|aspyridone A biosynthesis|aspyridone A formation|aspyridone A synthesis http://purl.obolibrary.org/obo/GO_1901518 GO:1901519 biolink:BiologicalProcess aspyridone B metabolic process The chemical reactions and pathways involving aspyridone B. go.json aspyridone B metabolism http://purl.obolibrary.org/obo/GO_1901519 GO:1901516 biolink:BiologicalProcess aspyridone A metabolic process The chemical reactions and pathways involving aspyridone A. go.json aspyridone A metabolism http://purl.obolibrary.org/obo/GO_1901516 GO:1901517 biolink:BiologicalProcess aspyridone A catabolic process The chemical reactions and pathways resulting in the breakdown of aspyridone A. go.json aspyridone A breakdown|aspyridone A catabolism|aspyridone A degradation http://purl.obolibrary.org/obo/GO_1901517 GO:1901514 biolink:MolecularActivity ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out). go.json lipo-chitin oligosaccharide transmembrane-transporting ATPase activity http://purl.obolibrary.org/obo/GO_1901514 GO:1901515 biolink:MolecularActivity poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901515 GO:1901512 biolink:BiologicalProcess (-)-microperfuranone biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-microperfuranone. go.json (-)-microperfuranone anabolism|(-)-microperfuranone biosynthesis|(-)-microperfuranone formation|(-)-microperfuranone synthesis http://purl.obolibrary.org/obo/GO_1901512 GO:1901513 biolink:MolecularActivity lipo-chitin oligosaccharide transmembrane transporter activity Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901513 GO:1901510 biolink:BiologicalProcess (-)-microperfuranone metabolic process The chemical reactions and pathways involving (-)-microperfuranone. go.json (-)-microperfuranone metabolism http://purl.obolibrary.org/obo/GO_1901510 GO:1901511 biolink:BiologicalProcess (-)-microperfuranone catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone. go.json (-)-microperfuranone breakdown|(-)-microperfuranone catabolism|(-)-microperfuranone degradation http://purl.obolibrary.org/obo/GO_1901511 GO:0060400 biolink:BiologicalProcess negative regulation of growth hormone receptor signaling pathway Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. go.json negative regulation of growth hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060400 GO:0060401 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060401 GO:0060402 biolink:BiologicalProcess calcium ion transport into cytosol The directed movement of calcium ions (Ca2+) into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0060402 GO:0060403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060403 GO:0060404 biolink:BiologicalProcess axonemal microtubule depolymerization The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. go.json http://purl.obolibrary.org/obo/GO_0060404 GO:0060405 biolink:BiologicalProcess regulation of penile erection Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. go.json http://purl.obolibrary.org/obo/GO_0060405 GO:0060406 biolink:BiologicalProcess positive regulation of penile erection Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. go.json http://purl.obolibrary.org/obo/GO_0060406 GO:0060407 biolink:BiologicalProcess negative regulation of penile erection Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. go.json http://purl.obolibrary.org/obo/GO_0060407 GO:0060408 biolink:BiologicalProcess regulation of acetylcholine metabolic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. go.json http://purl.obolibrary.org/obo/GO_0060408 GO:0060409 biolink:BiologicalProcess positive regulation of acetylcholine metabolic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. go.json http://purl.obolibrary.org/obo/GO_0060409 GO:1901529 biolink:BiologicalProcess positive regulation of anion channel activity Any process that activates or increases the frequency, rate or extent of anion channel activity. go.json activation of anion channel activity|up regulation of anion channel activity|up-regulation of anion channel activity|upregulation of anion channel activity http://purl.obolibrary.org/obo/GO_1901529 gocheck_do_not_annotate GO:1901527 biolink:BiologicalProcess abscisic acid-activated signaling pathway involved in stomatal movement Any abscisic acid mediated signaling pathway that is involved in stomatal movement. go.json abscisic acid mediated signaling pathway involved in stomatal movement|abscisic acid mediated signalling involved in stomatal movement http://purl.obolibrary.org/obo/GO_1901527 GO:1901528 biolink:BiologicalProcess hydrogen peroxide mediated signaling pathway involved in stomatal movement Any hydrogen peroxide mediated signaling pathway that is involved in stomatal movement. go.json H2O2 mediated signaling pathway involved in stomatal movement|hydrogen peroxide mediated signalling pathway involved in stomatal movement http://purl.obolibrary.org/obo/GO_1901528 GO:1901525 biolink:BiologicalProcess negative regulation of mitophagy Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy. go.json down regulation of macromitophagy|down-regulation of macromitophagy|downregulation of macromitophagy|inhibition of macromitophagy|negative regulation of macromitophagy http://purl.obolibrary.org/obo/GO_1901525 GO:1901526 biolink:BiologicalProcess positive regulation of mitophagy Any process that activates or increases the frequency, rate or extent of mitophagy. go.json activation of macromitophagy|positive regulation of macromitophagy|up regulation of macromitophagy|up-regulation of macromitophagy|upregulation of macromitophagy http://purl.obolibrary.org/obo/GO_1901526 GO:1901523 biolink:BiologicalProcess icosanoid catabolic process The chemical reactions and pathways resulting in the breakdown of icosanoid. go.json icosanoid breakdown|icosanoid catabolism|icosanoid degradation http://purl.obolibrary.org/obo/GO_1901523 GO:1901524 biolink:BiologicalProcess regulation of mitophagy Any process that modulates the frequency, rate or extent of macromitophagy. go.json regulation of macromitophagy http://purl.obolibrary.org/obo/GO_1901524 GO:1901521 biolink:BiologicalProcess aspyridone B biosynthetic process The chemical reactions and pathways resulting in the formation of aspyridone B. go.json aspyridone B anabolism|aspyridone B biosynthesis|aspyridone B formation|aspyridone B synthesis http://purl.obolibrary.org/obo/GO_1901521 GO:1901522 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. go.json activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus|positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus|stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus True http://purl.obolibrary.org/obo/GO_1901522 GO:1901520 biolink:BiologicalProcess aspyridone B catabolic process The chemical reactions and pathways resulting in the breakdown of aspyridone B. go.json aspyridone B breakdown|aspyridone B catabolism|aspyridone B degradation http://purl.obolibrary.org/obo/GO_1901520 GO:0060430 biolink:BiologicalProcess lung saccule development The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells. go.json lung saccular development http://purl.obolibrary.org/obo/GO_0060430 GO:0060431 biolink:BiologicalProcess primary lung bud formation The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. go.json lung formation http://purl.obolibrary.org/obo/GO_0060431 GO:0060432 biolink:BiologicalProcess lung pattern specification process Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate. go.json http://purl.obolibrary.org/obo/GO_0060432 GO:0060433 biolink:BiologicalProcess bronchus development The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. go.json http://purl.obolibrary.org/obo/GO_0060433 GO:0060434 biolink:BiologicalProcess bronchus morphogenesis The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. go.json http://purl.obolibrary.org/obo/GO_0060434 GO:0060435 biolink:BiologicalProcess bronchiole development The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. go.json http://purl.obolibrary.org/obo/GO_0060435 GO:0060436 biolink:BiologicalProcess bronchiole morphogenesis The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. go.json http://purl.obolibrary.org/obo/GO_0060436 GO:0060437 biolink:BiologicalProcess lung growth The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. go.json http://purl.obolibrary.org/obo/GO_0060437 GO:0060438 biolink:BiologicalProcess trachea development The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. go.json http://purl.obolibrary.org/obo/GO_0060438 GO:0060439 biolink:BiologicalProcess trachea morphogenesis The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. go.json http://purl.obolibrary.org/obo/GO_0060439 GO:1901538 biolink:BiologicalProcess obsolete changes to DNA methylation involved in embryo development OBSOLETE. The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression. go.json DNA methylation or demethylation involved in embryogenesis|DNA methylation or demethylation involved in embryonal development|changes in DNA methylation involved in embryo development|changes in DNA methylation involved in embryogenesis|changes in DNA methylation involved in embryonal development True http://purl.obolibrary.org/obo/GO_1901538 GO:1901539 biolink:BiologicalProcess ent-pimara-8(14),15-diene metabolic process The chemical reactions and pathways involving ent-pimara-8(14),15-diene. go.json ent-pimara-8(14),15-diene metabolism http://purl.obolibrary.org/obo/GO_1901539 GO:1901536 biolink:BiologicalProcess negative regulation of DNA demethylation Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation. go.json down regulation of DNA demethylation|down-regulation of DNA demethylation|downregulation of DNA demethylation|inhibition of DNA demethylation http://purl.obolibrary.org/obo/GO_1901536 GO:1901537 biolink:BiologicalProcess positive regulation of DNA demethylation Any process that activates or increases the frequency, rate or extent of DNA demethylation. go.json activation of DNA demethylation|up regulation of DNA demethylation|up-regulation of DNA demethylation|upregulation of DNA demethylation http://purl.obolibrary.org/obo/GO_1901537 GO:1901534 biolink:BiologicalProcess positive regulation of hematopoietic progenitor cell differentiation Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. go.json activation of haematopoietic progenitor cell differentiation|activation of haemopoietic progenitor cell differentiation|activation of hematopoietic progenitor cell differentiation|activation of hemopoietic progenitor cell differentiation|positive regulation of haematopoietic progenitor cell differentiation|positive regulation of haemopoietic progenitor cell differentiation|positive regulation of hemopoietic progenitor cell differentiation|up regulation of haematopoietic progenitor cell differentiation|up regulation of haemopoietic progenitor cell differentiation|up regulation of hematopoietic progenitor cell differentiation|up regulation of hemopoietic progenitor cell differentiation|up-regulation of haematopoietic progenitor cell differentiation|up-regulation of haemopoietic progenitor cell differentiation|up-regulation of hematopoietic progenitor cell differentiation|up-regulation of hemopoietic progenitor cell differentiation|upregulation of haematopoietic progenitor cell differentiation|upregulation of haemopoietic progenitor cell differentiation|upregulation of hematopoietic progenitor cell differentiation|upregulation of hemopoietic progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1901534 GO:1901535 biolink:BiologicalProcess regulation of DNA demethylation Any process that modulates the frequency, rate or extent of DNA demethylation. go.json http://purl.obolibrary.org/obo/GO_1901535 GO:1901532 biolink:BiologicalProcess regulation of hematopoietic progenitor cell differentiation Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. go.json regulation of haematopoietic progenitor cell differentiation|regulation of haemopoietic progenitor cell differentiation|regulation of hemopoietic progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1901532 GO:1901533 biolink:BiologicalProcess negative regulation of hematopoietic progenitor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. go.json down regulation of haematopoietic progenitor cell differentiation|down regulation of haemopoietic progenitor cell differentiation|down regulation of hematopoietic progenitor cell differentiation|down regulation of hemopoietic progenitor cell differentiation|down-regulation of haematopoietic progenitor cell differentiation|down-regulation of haemopoietic progenitor cell differentiation|down-regulation of hematopoietic progenitor cell differentiation|down-regulation of hemopoietic progenitor cell differentiation|downregulation of haematopoietic progenitor cell differentiation|downregulation of haemopoietic progenitor cell differentiation|downregulation of hematopoietic progenitor cell differentiation|downregulation of hemopoietic progenitor cell differentiation|inhibition of haematopoietic progenitor cell differentiation|inhibition of haemopoietic progenitor cell differentiation|inhibition of hematopoietic progenitor cell differentiation|inhibition of hemopoietic progenitor cell differentiation|negative regulation of haematopoietic progenitor cell differentiation|negative regulation of haemopoietic progenitor cell differentiation|negative regulation of hemopoietic progenitor cell differentiation http://purl.obolibrary.org/obo/GO_1901533 GO:1901530 biolink:BiologicalProcess response to hypochlorite Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus. go.json http://purl.obolibrary.org/obo/GO_1901530 GO:1901531 biolink:MolecularActivity hypochlorite binding Binding to hypochlorite. go.json http://purl.obolibrary.org/obo/GO_1901531 GO:0060420 biolink:BiologicalProcess regulation of heart growth Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. go.json http://purl.obolibrary.org/obo/GO_0060420 GO:0060421 biolink:BiologicalProcess positive regulation of heart growth Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. go.json http://purl.obolibrary.org/obo/GO_0060421 GO:0060422 biolink:MolecularActivity peptidyl-dipeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain. go.json http://purl.obolibrary.org/obo/GO_0060422 GO:0060423 biolink:BiologicalProcess foregut regionalization The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place. go.json http://purl.obolibrary.org/obo/GO_0060423 GO:0060424 biolink:BiologicalProcess lung field specification The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop. go.json lung specification http://purl.obolibrary.org/obo/GO_0060424 GO:0060425 biolink:BiologicalProcess lung morphogenesis The process in which the anatomical structures of the lung are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060425 GO:0060426 biolink:BiologicalProcess lung vasculature development The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. go.json pulmonary vasculature development http://purl.obolibrary.org/obo/GO_0060426 GO:0060427 biolink:BiologicalProcess lung connective tissue development The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. go.json pulmonary connective tissue development http://purl.obolibrary.org/obo/GO_0060427 GO:0060428 biolink:BiologicalProcess lung epithelium development The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. go.json pulmonary epithelium development http://purl.obolibrary.org/obo/GO_0060428 GO:0060429 biolink:BiologicalProcess epithelium development The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. go.json http://purl.obolibrary.org/obo/GO_0060429 goslim_drosophila OIO:hasBroadSynonym biolink:OntologyClass has_broad_synonym go.json http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym GO:1901549 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901549 GO:1901547 biolink:BiologicalProcess negative regulation of synaptic vesicle lumen acidification Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification. go.json down regulation of synaptic vesicle lumen acidification|down regulation of synaptic vesicle lumen pH reduction|down-regulation of synaptic vesicle lumen acidification|down-regulation of synaptic vesicle lumen pH reduction|downregulation of synaptic vesicle lumen acidification|downregulation of synaptic vesicle lumen pH reduction|inhibition of synaptic vesicle lumen acidification|inhibition of synaptic vesicle lumen pH reduction|negative regulation of proton loading|negative regulation of synaptic vesicle lumen pH reduction http://purl.obolibrary.org/obo/GO_1901547 GO:1901548 biolink:BiologicalProcess positive regulation of synaptic vesicle lumen acidification Any process that activates or increases the frequency, rate or extent of synaptic vesicle lumen acidification. go.json activation of synaptic vesicle lumen acidification|activation of synaptic vesicle lumen pH reduction|positive regulation of proton loading|positive regulation of synaptic vesicle lumen pH reduction|up regulation of synaptic vesicle lumen acidification|up regulation of synaptic vesicle lumen pH reduction|up-regulation of synaptic vesicle lumen acidification|up-regulation of synaptic vesicle lumen pH reduction|upregulation of synaptic vesicle lumen acidification|upregulation of synaptic vesicle lumen pH reduction http://purl.obolibrary.org/obo/GO_1901548 GO:1901545 biolink:BiologicalProcess response to raffinose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus. go.json http://purl.obolibrary.org/obo/GO_1901545 GO:1901546 biolink:BiologicalProcess regulation of synaptic vesicle lumen acidification Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification. go.json regulation of synaptic vesicle lumen pH reduction|regulation of synaptic vesicle lumen proton loading http://purl.obolibrary.org/obo/GO_1901546 goslim_synapse GO:1901543 biolink:BiologicalProcess negative regulation of ent-pimara-8(14),15-diene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. go.json down regulation of ent-pimara-8(14),15-diene anabolism|down regulation of ent-pimara-8(14),15-diene biosynthesis|down regulation of ent-pimara-8(14),15-diene biosynthetic process|down regulation of ent-pimara-8(14),15-diene formation|down regulation of ent-pimara-8(14),15-diene synthesis|down-regulation of ent-pimara-8(14),15-diene anabolism|down-regulation of ent-pimara-8(14),15-diene biosynthesis|down-regulation of ent-pimara-8(14),15-diene biosynthetic process|down-regulation of ent-pimara-8(14),15-diene formation|down-regulation of ent-pimara-8(14),15-diene synthesis|downregulation of ent-pimara-8(14),15-diene anabolism|downregulation of ent-pimara-8(14),15-diene biosynthesis|downregulation of ent-pimara-8(14),15-diene biosynthetic process|downregulation of ent-pimara-8(14),15-diene formation|downregulation of ent-pimara-8(14),15-diene synthesis|inhibition of ent-pimara-8(14),15-diene anabolism|inhibition of ent-pimara-8(14),15-diene biosynthesis|inhibition of ent-pimara-8(14),15-diene biosynthetic process|inhibition of ent-pimara-8(14),15-diene formation|inhibition of ent-pimara-8(14),15-diene synthesis|negative regulation of ent-pimara-8(14),15-diene anabolism|negative regulation of ent-pimara-8(14),15-diene biosynthesis|negative regulation of ent-pimara-8(14),15-diene formation|negative regulation of ent-pimara-8(14),15-diene synthesis http://purl.obolibrary.org/obo/GO_1901543 GO:1901544 biolink:BiologicalProcess positive regulation of ent-pimara-8(14),15-diene biosynthetic process Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. go.json activation of ent-pimara-8(14),15-diene anabolism|activation of ent-pimara-8(14),15-diene biosynthesis|activation of ent-pimara-8(14),15-diene biosynthetic process|activation of ent-pimara-8(14),15-diene formation|activation of ent-pimara-8(14),15-diene synthesis|positive regulation of ent-pimara-8(14),15-diene anabolism|positive regulation of ent-pimara-8(14),15-diene biosynthesis|positive regulation of ent-pimara-8(14),15-diene formation|positive regulation of ent-pimara-8(14),15-diene synthesis|up regulation of ent-pimara-8(14),15-diene anabolism|up regulation of ent-pimara-8(14),15-diene biosynthesis|up regulation of ent-pimara-8(14),15-diene biosynthetic process|up regulation of ent-pimara-8(14),15-diene formation|up regulation of ent-pimara-8(14),15-diene synthesis|up-regulation of ent-pimara-8(14),15-diene anabolism|up-regulation of ent-pimara-8(14),15-diene biosynthesis|up-regulation of ent-pimara-8(14),15-diene biosynthetic process|up-regulation of ent-pimara-8(14),15-diene formation|up-regulation of ent-pimara-8(14),15-diene synthesis|upregulation of ent-pimara-8(14),15-diene anabolism|upregulation of ent-pimara-8(14),15-diene biosynthesis|upregulation of ent-pimara-8(14),15-diene biosynthetic process|upregulation of ent-pimara-8(14),15-diene formation|upregulation of ent-pimara-8(14),15-diene synthesis http://purl.obolibrary.org/obo/GO_1901544 GO:1901541 biolink:BiologicalProcess ent-pimara-8(14),15-diene biosynthetic process The chemical reactions and pathways resulting in the formation of ent-pimara-8(14),15-diene. go.json ent-pimara-8(14),15-diene anabolism|ent-pimara-8(14),15-diene biosynthesis|ent-pimara-8(14),15-diene formation|ent-pimara-8(14),15-diene synthesis http://purl.obolibrary.org/obo/GO_1901541 GO:1901542 biolink:BiologicalProcess regulation of ent-pimara-8(14),15-diene biosynthetic process Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. go.json regulation of ent-pimara-8(14),15-diene anabolism|regulation of ent-pimara-8(14),15-diene biosynthesis|regulation of ent-pimara-8(14),15-diene formation|regulation of ent-pimara-8(14),15-diene synthesis http://purl.obolibrary.org/obo/GO_1901542 GO:0060450 biolink:BiologicalProcess positive regulation of hindgut contraction Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. go.json http://purl.obolibrary.org/obo/GO_0060450 GO:0060451 biolink:BiologicalProcess negative regulation of hindgut contraction Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. go.json http://purl.obolibrary.org/obo/GO_0060451 GO:1901540 biolink:BiologicalProcess ent-pimara-8(14),15-diene catabolic process The chemical reactions and pathways resulting in the breakdown of ent-pimara-8(14),15-diene. go.json ent-pimara-8(14),15-diene breakdown|ent-pimara-8(14),15-diene catabolism|ent-pimara-8(14),15-diene degradation http://purl.obolibrary.org/obo/GO_1901540 GO:0060452 biolink:BiologicalProcess positive regulation of cardiac muscle contraction Any process that increases the frequency, rate or extent of cardiac muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0060452 GO:0060453 biolink:BiologicalProcess regulation of gastric acid secretion Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. go.json http://purl.obolibrary.org/obo/GO_0060453 GO:0060454 biolink:BiologicalProcess positive regulation of gastric acid secretion Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. go.json http://purl.obolibrary.org/obo/GO_0060454 GO:0060455 biolink:BiologicalProcess negative regulation of gastric acid secretion Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. go.json http://purl.obolibrary.org/obo/GO_0060455 GO:0060456 biolink:BiologicalProcess positive regulation of digestive system process Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0060456 GO:0060457 biolink:BiologicalProcess negative regulation of digestive system process Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0060457 GO:0060458 biolink:BiologicalProcess right lung development The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. go.json right pulmonary development http://purl.obolibrary.org/obo/GO_0060458 GO:0060459 biolink:BiologicalProcess left lung development The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. go.json left pulmonary development http://purl.obolibrary.org/obo/GO_0060459 GO:1901558 biolink:BiologicalProcess response to metformin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901558 GO:1901559 biolink:BiologicalProcess response to ribavirin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901559 GO:1901556 biolink:BiologicalProcess response to candesartan Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus. go.json http://purl.obolibrary.org/obo/GO_1901556 GO:1901557 biolink:BiologicalProcess response to fenofibrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus. go.json http://purl.obolibrary.org/obo/GO_1901557 GO:1901554 biolink:BiologicalProcess response to paracetamol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus. go.json response to acetaminophen http://purl.obolibrary.org/obo/GO_1901554 GO:1901555 biolink:BiologicalProcess obsolete response to paclitaxel OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus. go.json True http://purl.obolibrary.org/obo/GO_1901555 GO:1901552 biolink:BiologicalProcess positive regulation of endothelial cell development Any process that activates or increases the frequency, rate or extent of endothelial cell development. go.json activation of endothelial cell development|up regulation of endothelial cell development|up-regulation of endothelial cell development|upregulation of endothelial cell development http://purl.obolibrary.org/obo/GO_1901552 GO:1901553 biolink:BiologicalProcess malonic acid transmembrane transport The directed movement of malonic acid across a membrane. go.json malonic acid membrane transport http://purl.obolibrary.org/obo/GO_1901553 GO:1901550 biolink:BiologicalProcess regulation of endothelial cell development Any process that modulates the frequency, rate or extent of endothelial cell development. go.json http://purl.obolibrary.org/obo/GO_1901550 GO:1901551 biolink:BiologicalProcess negative regulation of endothelial cell development Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. go.json down regulation of endothelial cell development|down-regulation of endothelial cell development|downregulation of endothelial cell development|inhibition of endothelial cell development http://purl.obolibrary.org/obo/GO_1901551 GO:0060440 biolink:BiologicalProcess trachea formation The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. go.json http://purl.obolibrary.org/obo/GO_0060440 GO:0060441 biolink:BiologicalProcess epithelial tube branching involved in lung morphogenesis The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. go.json lung branching morphogenesis http://purl.obolibrary.org/obo/GO_0060441 GO:0060442 biolink:BiologicalProcess branching involved in prostate gland morphogenesis The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. go.json prostate branching|prostate gland branching morphogenesis http://purl.obolibrary.org/obo/GO_0060442 GO:1901560 biolink:BiologicalProcess response to purvalanol A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus. go.json http://purl.obolibrary.org/obo/GO_1901560 GO:0060443 biolink:BiologicalProcess mammary gland morphogenesis The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. go.json http://purl.obolibrary.org/obo/GO_0060443 GO:0060444 biolink:BiologicalProcess branching involved in mammary gland duct morphogenesis The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. go.json mammary gland branching morphogenesis http://purl.obolibrary.org/obo/GO_0060444 GO:0060445 biolink:BiologicalProcess branching involved in salivary gland morphogenesis The process in which the branching structure of the salivary gland is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060445 GO:0060446 biolink:BiologicalProcess branching involved in open tracheal system development The process in which the anatomical structures of branches in the open tracheal system are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060446 GO:0060447 biolink:BiologicalProcess bud outgrowth involved in lung branching The process in which a region of the lung epithelium initiates an outgrowth. go.json bud formation involved in lung branching http://purl.obolibrary.org/obo/GO_0060447 GO:0060448 biolink:BiologicalProcess dichotomous subdivision of terminal units involved in lung branching The process in which a lung bud bifurcates. go.json bud bifurcation involved in lung branching http://purl.obolibrary.org/obo/GO_0060448 GO:0060449 biolink:BiologicalProcess bud elongation involved in lung branching The process in which a bud in the lung grows out from the point where it is formed. go.json http://purl.obolibrary.org/obo/GO_0060449 GO:0060610 biolink:BiologicalProcess mesenchymal cell differentiation involved in mammary gland development The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts. go.json mammary gland mesenchymal cell differentiation http://purl.obolibrary.org/obo/GO_0060610 GO:0060611 biolink:BiologicalProcess mammary gland fat development The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts. go.json http://purl.obolibrary.org/obo/GO_0060611 GO:0060612 biolink:BiologicalProcess adipose tissue development The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. go.json adipogenesis http://purl.obolibrary.org/obo/GO_0060612 GO:0060613 biolink:BiologicalProcess fat pad development The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue. go.json http://purl.obolibrary.org/obo/GO_0060613 GO:0060614 biolink:BiologicalProcess negative regulation of mammary gland development in males by androgen receptor signaling pathway Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell. go.json negative regulation of mammary gland development in males by androgen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060614 GO:0060615 biolink:BiologicalProcess mammary gland bud formation The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis. go.json http://purl.obolibrary.org/obo/GO_0060615 GO:0060616 biolink:BiologicalProcess mammary gland cord formation The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad. go.json mammary gland sprout formation http://purl.obolibrary.org/obo/GO_0060616 GO:0060617 biolink:BiologicalProcess positive regulation of mammary placode formation by mesenchymal-epithelial signaling Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode. go.json positive regulation of mammary placode formation by mesenchymal-epithelial signalling http://purl.obolibrary.org/obo/GO_0060617 GO:0060618 biolink:BiologicalProcess nipple development The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm. go.json http://purl.obolibrary.org/obo/GO_0060618 GO:0060619 biolink:BiologicalProcess cell migration involved in mammary placode formation The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode. go.json http://purl.obolibrary.org/obo/GO_0060619 GO:0060600 biolink:BiologicalProcess dichotomous subdivision of an epithelial terminal unit The process in which an epithelial cord, rod or tube bifurcates at its end. go.json primary branching of an epithelium http://purl.obolibrary.org/obo/GO_0060600 GO:0060601 biolink:BiologicalProcess lateral sprouting from an epithelium The process in which a branch forms along the side of an epithelium. go.json http://purl.obolibrary.org/obo/GO_0060601 GO:0060602 biolink:BiologicalProcess branch elongation of an epithelium The growth process in which a branch increases in length from its base to its tip. go.json http://purl.obolibrary.org/obo/GO_0060602 GO:0060603 biolink:BiologicalProcess mammary gland duct morphogenesis The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. go.json http://purl.obolibrary.org/obo/GO_0060603 GO:0060604 biolink:BiologicalProcess mammary gland duct cavitation Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod. go.json milk duct cavitation http://purl.obolibrary.org/obo/GO_0060604 GO:0060605 biolink:BiologicalProcess tube lumen cavitation The formation of a lumen by hollowing out a solid rod or cord. go.json http://purl.obolibrary.org/obo/GO_0060605 GO:0060606 biolink:BiologicalProcess tube closure Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold. go.json http://purl.obolibrary.org/obo/GO_0060606 GO:0060607 biolink:BiologicalProcess cell-cell adhesion involved in sealing an epithelial fold The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube. go.json http://purl.obolibrary.org/obo/GO_0060607 GO:0060608 biolink:BiologicalProcess cell-cell adhesion involved in neural tube closure The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube. go.json http://purl.obolibrary.org/obo/GO_0060608 GO:0060609 biolink:BiologicalProcess apoptotic process involved in tube lumen cavitation Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube. go.json apoptosis involved in tube lumen cavitation http://purl.obolibrary.org/obo/GO_0060609 GO:0035669 biolink:BiologicalProcess TRAM-dependent toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. go.json TRAM-dependent TLR4 signaling pathway|TRAM-dependent toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0035669 GO:0035661 biolink:BiologicalProcess MyD88-dependent toll-like receptor 2 signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response. go.json MyD88-dependent TLR2 signaling pathway|MyD88-dependent toll-like receptor 2 signalling pathway http://purl.obolibrary.org/obo/GO_0035661 GO:0035662 biolink:MolecularActivity Toll-like receptor 4 binding Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. go.json TLR4 binding http://purl.obolibrary.org/obo/GO_0035662 GO:0035663 biolink:MolecularActivity Toll-like receptor 2 binding Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. go.json TLR2 binding http://purl.obolibrary.org/obo/GO_0035663 GO:0035664 biolink:BiologicalProcess TIRAP-dependent toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. go.json MAL-dependent toll-like receptor signaling pathway|MyD88 adapter-like dependent toll-like receptor signaling pathway|TIRAP-dependent TLR signaling pathway|TIRAP-dependent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0035664 GO:0035665 biolink:BiologicalProcess TIRAP-dependent toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. go.json MAL-dependent toll-like receptor 4 signaling pathway|MyD88 adapter-like dependent toll-like receptor 4 signaling pathway|TIRAP-dependent TLR4 signaling pathway|TIRAP-dependent toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0035665 GO:0035666 biolink:BiologicalProcess TRIF-dependent toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. go.json TRIF-dependent TLR signaling pathway|TRIF-dependent toll-like receptor signalling pathway|Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway http://purl.obolibrary.org/obo/GO_0035666 GO:0035667 biolink:BiologicalProcess TRIF-dependent toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. go.json TRIF-dependent TLR4 signaling pathway|TRIF-dependent toll-like receptor 4 signalling pathway|Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway http://purl.obolibrary.org/obo/GO_0035667 GO:0035668 biolink:BiologicalProcess TRAM-dependent toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. go.json TRAM-dependent TLR signaling pathway|TRAM-dependent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0035668 GO:0035660 biolink:BiologicalProcess MyD88-dependent toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. go.json MyD88-dependent TLR4 signaling pathway|MyD88-dependent toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0035660 GO:0035658 biolink:CellularComponent Mon1-Ccz1 complex A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. go.json http://purl.obolibrary.org/obo/GO_0035658 GO:0035659 biolink:BiologicalProcess Wnt signaling pathway involved in wound healing, spreading of epidermal cells The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis. go.json Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells|Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells http://purl.obolibrary.org/obo/GO_0035659 GO:0035650 biolink:MolecularActivity AP-1 adaptor complex binding Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). go.json http://purl.obolibrary.org/obo/GO_0035650 GO:0035651 biolink:MolecularActivity AP-3 adaptor complex binding Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). go.json http://purl.obolibrary.org/obo/GO_0035651 GO:0035652 biolink:BiologicalProcess clathrin-coated vesicle cargo loading Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle. go.json cargo loading into clathrin-coated vesicle http://purl.obolibrary.org/obo/GO_0035652 GO:0035653 biolink:BiologicalProcess clathrin-coated vesicle cargo loading, AP-1-mediated Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking. go.json cargo loading into clathrin-coated vesicle, AP-1-mediated http://purl.obolibrary.org/obo/GO_0035653 GO:0035654 biolink:BiologicalProcess clathrin-coated vesicle cargo loading, AP-3-mediated Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle. go.json cargo loading into clathrin-coated vesicle, AP-3-mediated http://purl.obolibrary.org/obo/GO_0035654 GO:0035655 biolink:BiologicalProcess interleukin-18-mediated signaling pathway The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json interleukin-18-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0035655 GO:0035656 biolink:MolecularActivity obsolete kinesin-associated melanosomal adaptor activity OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes. go.json kinesin-melanosome adaptor activity True http://purl.obolibrary.org/obo/GO_0035656 GO:0035657 biolink:CellularComponent eRF1 methyltransferase complex A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p. go.json eRF1 MTase complex http://purl.obolibrary.org/obo/GO_0035657 GO:0035647 biolink:MolecularActivity 3-oxo-delta(4,5)-steroid 5-beta-reductase activity Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H+ = a 5-beta-3-oxo-steroid + NADP+. go.json 3-oxo-delta4,5-steroid 5beta-reductase http://purl.obolibrary.org/obo/GO_0035647 GO:0035648 biolink:BiologicalProcess circadian mating behavior The fluctuation in mating behavior that occurs over an approximately 24 hour cycle. go.json circadian mating behaviour|circadian mating rhythm http://purl.obolibrary.org/obo/GO_0035648 GO:0035649 biolink:CellularComponent Nrd1 complex A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p. go.json http://purl.obolibrary.org/obo/GO_0035649 GO:0035640 biolink:BiologicalProcess exploration behavior The specific behavior of an organism in response to a novel environment or stimulus. go.json exploration behaviour|exploratory behavior|exploratory behaviour|open-field behavior http://purl.obolibrary.org/obo/GO_0035640 GO:0035641 biolink:BiologicalProcess locomotory exploration behavior The specific movement from place to place of an organism in response to a novel environment. go.json http://purl.obolibrary.org/obo/GO_0035641 GO:0035642 biolink:MolecularActivity histone H3R17 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3. go.json histone methylase activity (H3-R17 specific)|histone methyltransferase activity (H3-R17 specific)|histone-H3R17 methyltransferase activity|histone-arginine N-methyltransferase activity (H3-R17 specific) http://purl.obolibrary.org/obo/GO_0035642 GO:0035643 biolink:MolecularActivity L-DOPA receptor activity Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine. go.json L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity http://purl.obolibrary.org/obo/GO_0035643 GO:0035644 biolink:BiologicalProcess phosphoanandamide dephosphorylation The process of removing one or more phosphate groups from a phosphorylated anandamide. go.json http://purl.obolibrary.org/obo/GO_0035644 GO:0035645 biolink:BiologicalProcess enteric smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. go.json intestinal smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_0035645 GO:0035646 biolink:BiologicalProcess endosome to melanosome transport The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle. go.json http://purl.obolibrary.org/obo/GO_0035646 GO:0035636 biolink:BiologicalProcess obsolete multi-organism signaling OBSOLETE. The transfer of information between living organisms. go.json multi-organism signalling|pheromone signaling|signaling between organisms|signaling with other organism True http://purl.obolibrary.org/obo/GO_0035636 GO:0035637 biolink:BiologicalProcess obsolete multicellular organismal signaling OBSOLETE. The transfer of information occurring at the level of a multicellular organism. go.json multicellular organismal signalling True http://purl.obolibrary.org/obo/GO_0035637 GO:0035638 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035638 GO:0035639 biolink:MolecularActivity purine ribonucleoside triphosphate binding Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json purine NTP binding http://purl.obolibrary.org/obo/GO_0035639 GO:0035630 biolink:BiologicalProcess bone mineralization involved in bone maturation The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0035630 GO:0035631 biolink:CellularComponent CD40 receptor complex A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. go.json http://purl.obolibrary.org/obo/GO_0035631 GO:0035632 biolink:CellularComponent mitochondrial prohibitin complex A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death. go.json mitochondrial inner membrane prohibitin complex http://purl.obolibrary.org/obo/GO_0035632 GO:0035633 biolink:BiologicalProcess maintenance of blood-brain barrier Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation. go.json maintenance of BBB|maintenance of blood/brain barrier http://purl.obolibrary.org/obo/GO_0035633 GO:0035634 biolink:BiologicalProcess response to stilbenoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. go.json http://purl.obolibrary.org/obo/GO_0035634 goslim_chembl GO:0035635 biolink:BiologicalProcess entry of bacterium into host cell The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json bacterial entry into host cell|invasion of bacteria into host cell http://purl.obolibrary.org/obo/GO_0035635 GO:0035625 biolink:BiologicalProcess obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway OBSOLETE. The process in which an epidermal growth factor-activated receptor is activated via signaling events from a consequence of a G protein-coupled . This is an example of cross-talk between the EGF and GPCR signaling pathways. go.json EGFR transactivation by GPCR|EGFR transactivation upon GPCR stimulation|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signalling pathway True http://purl.obolibrary.org/obo/GO_0035625 GO:0035626 biolink:BiologicalProcess juvenile hormone mediated signaling pathway The series of molecular signals initiated by a juvenile hormone binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json juvenile hormone mediated signalling pathway|juvenile hormone-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0035626 GO:0035627 biolink:BiologicalProcess ceramide transport The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. go.json http://purl.obolibrary.org/obo/GO_0035627 GO:0035628 biolink:BiologicalProcess cystic duct development The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. go.json http://purl.obolibrary.org/obo/GO_0035628 GO:0035629 biolink:BiologicalProcess N-terminal protein amino acid N-linked glycosylation Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein. go.json http://purl.obolibrary.org/obo/GO_0035629 GO:0035620 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035620 GO:0035621 biolink:BiologicalProcess ER to Golgi ceramide transport The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. go.json ER to Golgi ceramide translocation|endoplasmic reticulum to Golgi ceramide transport|non-vesicular ceramide trafficking http://purl.obolibrary.org/obo/GO_0035621 GO:0035622 biolink:BiologicalProcess intrahepatic bile duct development The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). go.json IHBD development|intrahepatic biliary duct development http://purl.obolibrary.org/obo/GO_0035622 GO:0035623 biolink:BiologicalProcess renal glucose absorption A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. go.json glucose reabsorption|nephron glucose absorption http://purl.obolibrary.org/obo/GO_0035623 GO:0035624 biolink:BiologicalProcess receptor transactivation The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer. go.json http://purl.obolibrary.org/obo/GO_0035624 gocheck_do_not_annotate GO:0035614 biolink:MolecularActivity snRNA stem-loop binding Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. go.json small nuclear RNA stem-loop binding|snRNA hairpin binding|snRNA hairpin loop binding http://purl.obolibrary.org/obo/GO_0035614 GO:0035615 biolink:MolecularActivity clathrin adaptor activity Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. go.json clathrin-associated adaptor activity http://purl.obolibrary.org/obo/GO_0035615 GO:0035616 biolink:BiologicalProcess histone H2B conserved C-terminal lysine deubiquitination A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. go.json budding yeast H2B K123 deubiquitination|fission yeast H2B K119 deubiquitination|mammalian H2B K120 deubiquitination http://purl.obolibrary.org/obo/GO_0035616 GO:0035617 biolink:BiologicalProcess stress granule disassembly The disaggregation of a stress granule into its constituent protein and RNA parts. go.json SG disassembly http://purl.obolibrary.org/obo/GO_0035617 GO:0035618 biolink:CellularComponent root hair A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall. go.json http://purl.obolibrary.org/obo/GO_0035618 GO:0035619 biolink:CellularComponent root hair tip The tip portion of an outgrowth of a root epidermal cell. go.json root hair cell tip http://purl.obolibrary.org/obo/GO_0035619 GO:0035610 biolink:BiologicalProcess protein side chain deglutamylation The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation. go.json removal of posttranslational polyglutamylation|shortening of glutamate side chain http://purl.obolibrary.org/obo/GO_0035610 gocheck_do_not_annotate GO:0035611 biolink:BiologicalProcess protein branching point deglutamylation The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue. go.json http://purl.obolibrary.org/obo/GO_0035611 gocheck_do_not_annotate GO:0035612 biolink:MolecularActivity AP-2 adaptor complex binding Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). go.json AP-2 clathrin adaptor complex binding http://purl.obolibrary.org/obo/GO_0035612 GO:0035613 biolink:MolecularActivity RNA stem-loop binding Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. go.json RNA hairpin binding|RNA hairpin loop binding http://purl.obolibrary.org/obo/GO_0035613 GO:0035603 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in hemopoiesis The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis. go.json FGF receptor signaling pathway involved in hematopoiesis|FGFR signaling pathway involved in hematopoiesis|fibroblast growth factor receptor signaling pathway involved in hematopoiesis|fibroblast growth factor receptor signalling pathway involved in hemopoiesis http://purl.obolibrary.org/obo/GO_0035603 GO:0035604 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. go.json FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow|fibroblast growth factor receptor signalling pathway involved in positive regulation of cell proliferation in bone marrow http://purl.obolibrary.org/obo/GO_0035604 GO:0035605 biolink:MolecularActivity peptidyl-cysteine S-nitrosylase activity Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein. go.json S-nitrosylase activity|protein nitrosylase activity http://purl.obolibrary.org/obo/GO_0035605 GO:0035606 biolink:BiologicalProcess peptidyl-cysteine S-trans-nitrosylation Transfer of a nitric oxide (NO) group from one cysteine residue to another. go.json S-transnitrosylation|cysteine to cysteine nitrosylation|cysteine-to-cysteine transnitrosylation|protein-to-protein transnitrosylation http://purl.obolibrary.org/obo/GO_0035606 gocheck_do_not_annotate GO:0035607 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state. go.json FGF receptor signaling pathway involved in orbitofrontal cortex development|FGFR signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development http://purl.obolibrary.org/obo/GO_0035607 GO:0035608 biolink:BiologicalProcess protein deglutamylation The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation. go.json protein amino acid deglutamylation http://purl.obolibrary.org/obo/GO_0035608 gocheck_do_not_annotate GO:0035609 biolink:BiologicalProcess C-terminal protein deglutamylation The removal of a C-terminal, gene-encoded glutamate residue from a protein. go.json protein primary sequence deglutamylation http://purl.obolibrary.org/obo/GO_0035609 gocheck_do_not_annotate GO:0035600 biolink:BiologicalProcess tRNA methylthiolation The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0035600 GO:0035601 biolink:BiologicalProcess protein deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid. go.json protein amino acid deacylation http://purl.obolibrary.org/obo/GO_0035601 gocheck_do_not_annotate GO:0035602 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow. go.json FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow|fibroblast growth factor receptor signalling pathway involved in negative regulation of apoptotic process in bone marrow http://purl.obolibrary.org/obo/GO_0035602 GO:1901448 biolink:BiologicalProcess regulation of response to butan-1-ol Any process that modulates the frequency, rate or extent of response to butan-1-ol. go.json http://purl.obolibrary.org/obo/GO_1901448 GO:1901449 biolink:BiologicalProcess negative regulation of response to butan-1-ol Any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol. go.json down regulation of response to butan-1-ol|down-regulation of response to butan-1-ol|downregulation of response to butan-1-ol|inhibition of response to butan-1-ol http://purl.obolibrary.org/obo/GO_1901449 GO:1901446 biolink:BiologicalProcess negative regulation of response to propan-1-ol Any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol. go.json down regulation of response to propan-1-ol|down-regulation of response to propan-1-ol|downregulation of response to propan-1-ol|inhibition of response to propan-1-ol http://purl.obolibrary.org/obo/GO_1901446 GO:1901447 biolink:BiologicalProcess positive regulation of response to propan-1-ol Any process that activates or increases the frequency, rate or extent of response to propan-1-ol. go.json activation of response to propan-1-ol|up regulation of response to propan-1-ol|up-regulation of response to propan-1-ol|upregulation of response to propan-1-ol http://purl.obolibrary.org/obo/GO_1901447 GO:1901444 biolink:BiologicalProcess positive regulation of response to furfural Any process that activates or increases the frequency, rate or extent of response to furfural. go.json activation of response to furfural|up regulation of response to furfural|up-regulation of response to furfural|upregulation of response to furfural http://purl.obolibrary.org/obo/GO_1901444 GO:1901445 biolink:BiologicalProcess regulation of response to propan-1-ol Any process that modulates the frequency, rate or extent of response to propan-1-ol. go.json http://purl.obolibrary.org/obo/GO_1901445 GO:0060590 biolink:MolecularActivity ATPase regulator activity Binds to and modulates the activity of an ATP hydrolysis activity. go.json ATP hydrolysis regulator activity http://purl.obolibrary.org/obo/GO_0060590 GO:1901442 biolink:BiologicalProcess regulation of response to furfural Any process that modulates the frequency, rate or extent of response to furfural. go.json http://purl.obolibrary.org/obo/GO_1901442 GO:0060591 biolink:BiologicalProcess chondroblast differentiation The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. go.json chondrocyte progenitor cell differentiation http://purl.obolibrary.org/obo/GO_0060591 GO:0060592 biolink:BiologicalProcess mammary gland formation The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme. go.json mammary bud formation|mammary line formation|mammary placode formation|mammary sprout formation http://purl.obolibrary.org/obo/GO_0060592 GO:1901443 biolink:BiologicalProcess negative regulation of response to furfural Any process that stops, prevents or reduces the frequency, rate or extent of response to furfural. go.json down regulation of response to furfural|down-regulation of response to furfural|downregulation of response to furfural|inhibition of response to furfural http://purl.obolibrary.org/obo/GO_1901443 GO:0060593 biolink:BiologicalProcess Wnt signaling pathway involved in mammary gland specification The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes. go.json Wnt receptor signaling pathway involved in mammary gland specification|Wnt receptor signalling pathway involved in mammary gland specification|Wnt-activated signaling pathway involved in mammary gland specification http://purl.obolibrary.org/obo/GO_0060593 GO:1901440 biolink:BiologicalProcess poly(hydroxyalkanoate) metabolic process The chemical reactions and pathways involving poly(hydroxyalkanoate). go.json poly(hydroxyalkanoate) metabolism http://purl.obolibrary.org/obo/GO_1901440 GO:0060594 biolink:BiologicalProcess mammary gland specification The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes. go.json mammary line specification http://purl.obolibrary.org/obo/GO_0060594 GO:1901441 biolink:BiologicalProcess poly(hydroxyalkanoate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate). go.json poly(hydroxyalkanoate) anabolism|poly(hydroxyalkanoate) biosynthesis|poly(hydroxyalkanoate) formation|poly(hydroxyalkanoate) synthesis http://purl.obolibrary.org/obo/GO_1901441 GO:0060595 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in mammary gland specification The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes. go.json fibroblast growth factor receptor signalling pathway involved in mammary gland specification http://purl.obolibrary.org/obo/GO_0060595 GO:1901450 biolink:BiologicalProcess positive regulation of response to butan-1-ol Any process that activates or increases the frequency, rate or extent of response to butan-1-ol. go.json activation of response to butan-1-ol|up regulation of response to butan-1-ol|up-regulation of response to butan-1-ol|upregulation of response to butan-1-ol http://purl.obolibrary.org/obo/GO_1901450 GO:0060596 biolink:BiologicalProcess mammary placode formation The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper. go.json http://purl.obolibrary.org/obo/GO_0060596 GO:0060597 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in mammary gland formation OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud. go.json True http://purl.obolibrary.org/obo/GO_0060597 GO:0060598 biolink:BiologicalProcess dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis The process in which the terminal end of a mammary duct bifurcates. go.json primary mammary duct branching http://purl.obolibrary.org/obo/GO_0060598 GO:0060599 biolink:BiologicalProcess lateral sprouting involved in mammary gland duct morphogenesis The process in which a branch forms along the side of a mammary duct. go.json mammary gland duct secondary branching http://purl.obolibrary.org/obo/GO_0060599 GO:1901459 biolink:BiologicalProcess positive regulation of response to acetate Any process that activates or increases the frequency, rate or extent of response to acetate. go.json activation of response to acetate|up regulation of response to acetate|up-regulation of response to acetate|upregulation of response to acetate http://purl.obolibrary.org/obo/GO_1901459 GO:1901457 biolink:BiologicalProcess regulation of response to acetate Any process that modulates the frequency, rate or extent of response to acetate. go.json http://purl.obolibrary.org/obo/GO_1901457 GO:1901458 biolink:BiologicalProcess negative regulation of response to acetate Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate. go.json down regulation of response to acetate|down-regulation of response to acetate|downregulation of response to acetate|inhibition of response to acetate http://purl.obolibrary.org/obo/GO_1901458 GO:1901455 biolink:BiologicalProcess negative regulation of response to toluene Any process that stops, prevents or reduces the frequency, rate or extent of response to toluene. go.json down regulation of response to toluene|down-regulation of response to toluene|downregulation of response to toluene|inhibition of response to toluene http://purl.obolibrary.org/obo/GO_1901455 GO:1901456 biolink:BiologicalProcess positive regulation of response to toluene Any process that activates or increases the frequency, rate or extent of response to toluene. go.json activation of response to toluene|up regulation of response to toluene|up-regulation of response to toluene|upregulation of response to toluene http://purl.obolibrary.org/obo/GO_1901456 GO:0060580 biolink:BiologicalProcess ventral spinal cord interneuron fate determination The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. go.json http://purl.obolibrary.org/obo/GO_0060580 GO:1901453 biolink:BiologicalProcess positive regulation of response to benzene Any process that activates or increases the frequency, rate or extent of response to benzene. go.json activation of response to benzene|up regulation of response to benzene|up-regulation of response to benzene|upregulation of response to benzene http://purl.obolibrary.org/obo/GO_1901453 GO:0060581 biolink:BiologicalProcess cell fate commitment involved in pattern specification The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. go.json http://purl.obolibrary.org/obo/GO_0060581 GO:1901454 biolink:BiologicalProcess regulation of response to toluene Any process that modulates the frequency, rate or extent of response to toluene. go.json http://purl.obolibrary.org/obo/GO_1901454 GO:1901451 biolink:BiologicalProcess regulation of response to benzene Any process that modulates the frequency, rate or extent of response to benzene. go.json http://purl.obolibrary.org/obo/GO_1901451 GO:0060582 biolink:BiologicalProcess cell fate determination involved in pattern specification A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. go.json http://purl.obolibrary.org/obo/GO_0060582 GO:1901452 biolink:BiologicalProcess negative regulation of response to benzene Any process that stops, prevents or reduces the frequency, rate or extent of response to benzene. go.json down regulation of response to benzene|down-regulation of response to benzene|downregulation of response to benzene|inhibition of response to benzene http://purl.obolibrary.org/obo/GO_1901452 GO:0060583 biolink:BiologicalProcess regulation of actin cortical patch localization Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. go.json regulation of actin cortical patch localisation http://purl.obolibrary.org/obo/GO_0060583 GO:1901460 biolink:BiologicalProcess regulation of response to formic acid Any process that modulates the frequency, rate or extent of response to formic acid. go.json http://purl.obolibrary.org/obo/GO_1901460 GO:0060584 biolink:BiologicalProcess regulation of prostaglandin-endoperoxide synthase activity Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. go.json regulation of (PG)H synthase activity|regulation of PG synthetase activity|regulation of fatty acid cyclooxygenase activity|regulation of prostaglandin synthetase activity http://purl.obolibrary.org/obo/GO_0060584 gocheck_do_not_annotate GO:1901461 biolink:BiologicalProcess negative regulation of response to formic acid Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid. go.json down regulation of response to formic acid|down-regulation of response to formic acid|downregulation of response to formic acid|inhibition of response to formic acid http://purl.obolibrary.org/obo/GO_1901461 GO:0060585 biolink:BiologicalProcess positive regulation of prostaglandin-endoperoxide synthase activity Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. go.json positive regulation of (PG)H synthase activity|positive regulation of PG synthetase activity|positive regulation of fatty acid cyclooxygenase activity|positive regulation of prostaglandin synthetase activity http://purl.obolibrary.org/obo/GO_0060585 gocheck_do_not_annotate GO:0060586 biolink:BiologicalProcess multicellular organismal-level iron ion homeostasis A chemical homeostatic process involved in the maintenance of a steady state level of iron within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. go.json multicellular organismal iron ion homeostasis http://purl.obolibrary.org/obo/GO_0060586 GO:0060587 biolink:BiologicalProcess regulation of lipoprotein lipid oxidation Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group. go.json http://purl.obolibrary.org/obo/GO_0060587 GO:0060588 biolink:BiologicalProcess negative regulation of lipoprotein lipid oxidation Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group. go.json http://purl.obolibrary.org/obo/GO_0060588 GO:0060589 biolink:MolecularActivity nucleoside-triphosphatase regulator activity Binds to and modulates the activity of an NTPase. go.json NTPase regulator activity http://purl.obolibrary.org/obo/GO_0060589 GO:1901468 biolink:BiologicalProcess positive regulation of ferulate catabolic process Any process that activates or increases the frequency, rate or extent of ferulate catabolic process. go.json activation of ferulate breakdown|activation of ferulate catabolic process|activation of ferulate catabolism|activation of ferulate degradation|positive regulation of ferulate breakdown|positive regulation of ferulate catabolism|positive regulation of ferulate degradation|up regulation of ferulate breakdown|up regulation of ferulate catabolic process|up regulation of ferulate catabolism|up regulation of ferulate degradation|up-regulation of ferulate breakdown|up-regulation of ferulate catabolic process|up-regulation of ferulate catabolism|up-regulation of ferulate degradation|upregulation of ferulate breakdown|upregulation of ferulate catabolic process|upregulation of ferulate catabolism|upregulation of ferulate degradation http://purl.obolibrary.org/obo/GO_1901468 GO:1901469 biolink:BiologicalProcess regulation of syringal lignin catabolic process Any process that modulates the frequency, rate or extent of syringal lignin catabolic process. go.json regulation of S-lignin catabolic process|regulation of syringal lignin breakdown|regulation of syringal lignin catabolism|regulation of syringal lignin degradation http://purl.obolibrary.org/obo/GO_1901469 GO:1901466 biolink:BiologicalProcess regulation of ferulate catabolic process Any process that modulates the frequency, rate or extent of ferulate catabolic process. go.json regulation of ferulate breakdown|regulation of ferulate catabolism|regulation of ferulate degradation http://purl.obolibrary.org/obo/GO_1901466 GO:1901467 biolink:BiologicalProcess negative regulation of ferulate catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process. go.json down regulation of ferulate breakdown|down regulation of ferulate catabolic process|down regulation of ferulate catabolism|down regulation of ferulate degradation|down-regulation of ferulate breakdown|down-regulation of ferulate catabolic process|down-regulation of ferulate catabolism|down-regulation of ferulate degradation|downregulation of ferulate breakdown|downregulation of ferulate catabolic process|downregulation of ferulate catabolism|downregulation of ferulate degradation|inhibition of ferulate breakdown|inhibition of ferulate catabolic process|inhibition of ferulate catabolism|inhibition of ferulate degradation|negative regulation of ferulate breakdown|negative regulation of ferulate catabolism|negative regulation of ferulate degradation http://purl.obolibrary.org/obo/GO_1901467 GO:1901464 biolink:BiologicalProcess negative regulation of tetrapyrrole biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process. go.json down regulation of tetrapyrrole anabolism|down regulation of tetrapyrrole biosynthesis|down regulation of tetrapyrrole biosynthetic process|down regulation of tetrapyrrole formation|down regulation of tetrapyrrole synthesis|down-regulation of tetrapyrrole anabolism|down-regulation of tetrapyrrole biosynthesis|down-regulation of tetrapyrrole biosynthetic process|down-regulation of tetrapyrrole formation|down-regulation of tetrapyrrole synthesis|downregulation of tetrapyrrole anabolism|downregulation of tetrapyrrole biosynthesis|downregulation of tetrapyrrole biosynthetic process|downregulation of tetrapyrrole formation|downregulation of tetrapyrrole synthesis|inhibition of tetrapyrrole anabolism|inhibition of tetrapyrrole biosynthesis|inhibition of tetrapyrrole biosynthetic process|inhibition of tetrapyrrole formation|inhibition of tetrapyrrole synthesis|negative regulation of tetrapyrrole anabolism|negative regulation of tetrapyrrole biosynthesis|negative regulation of tetrapyrrole formation|negative regulation of tetrapyrrole synthesis http://purl.obolibrary.org/obo/GO_1901464 GO:1901465 biolink:BiologicalProcess positive regulation of tetrapyrrole biosynthetic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process. go.json activation of tetrapyrrole anabolism|activation of tetrapyrrole biosynthesis|activation of tetrapyrrole biosynthetic process|activation of tetrapyrrole formation|activation of tetrapyrrole synthesis|positive regulation of tetrapyrrole anabolism|positive regulation of tetrapyrrole biosynthesis|positive regulation of tetrapyrrole formation|positive regulation of tetrapyrrole synthesis|up regulation of tetrapyrrole anabolism|up regulation of tetrapyrrole biosynthesis|up regulation of tetrapyrrole biosynthetic process|up regulation of tetrapyrrole formation|up regulation of tetrapyrrole synthesis|up-regulation of tetrapyrrole anabolism|up-regulation of tetrapyrrole biosynthesis|up-regulation of tetrapyrrole biosynthetic process|up-regulation of tetrapyrrole formation|up-regulation of tetrapyrrole synthesis|upregulation of tetrapyrrole anabolism|upregulation of tetrapyrrole biosynthesis|upregulation of tetrapyrrole biosynthetic process|upregulation of tetrapyrrole formation|upregulation of tetrapyrrole synthesis http://purl.obolibrary.org/obo/GO_1901465 GO:1901462 biolink:BiologicalProcess positive regulation of response to formic acid Any process that activates or increases the frequency, rate or extent of response to formic acid. go.json activation of response to formic acid|up regulation of response to formic acid|up-regulation of response to formic acid|upregulation of response to formic acid http://purl.obolibrary.org/obo/GO_1901462 GO:1901463 biolink:BiologicalProcess regulation of tetrapyrrole biosynthetic process Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process. go.json regulation of tetrapyrrole anabolism|regulation of tetrapyrrole biosynthesis|regulation of tetrapyrrole formation|regulation of tetrapyrrole synthesis http://purl.obolibrary.org/obo/GO_1901463 GO:1901471 biolink:BiologicalProcess positive regulation of syringal lignin catabolic process Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process. go.json activation of S-lignin catabolic process|activation of syringal lignin breakdown|activation of syringal lignin catabolic process|activation of syringal lignin catabolism|activation of syringal lignin degradation|positive regulation of S-lignin catabolic process|positive regulation of syringal lignin breakdown|positive regulation of syringal lignin catabolism|positive regulation of syringal lignin degradation|up regulation of S-lignin catabolic process|up regulation of syringal lignin breakdown|up regulation of syringal lignin catabolic process|up regulation of syringal lignin catabolism|up regulation of syringal lignin degradation|up-regulation of S-lignin catabolic process|up-regulation of syringal lignin breakdown|up-regulation of syringal lignin catabolic process|up-regulation of syringal lignin catabolism|up-regulation of syringal lignin degradation|upregulation of S-lignin catabolic process|upregulation of syringal lignin breakdown|upregulation of syringal lignin catabolic process|upregulation of syringal lignin catabolism|upregulation of syringal lignin degradation http://purl.obolibrary.org/obo/GO_1901471 GO:1901472 biolink:BiologicalProcess regulation of Golgi calcium ion export Any process that modulates the frequency, rate or extent of Golgi calcium ion export. go.json http://purl.obolibrary.org/obo/GO_1901472 GO:1901470 biolink:BiologicalProcess negative regulation of syringal lignin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process. go.json down regulation of S-lignin catabolic process|down regulation of syringal lignin breakdown|down regulation of syringal lignin catabolic process|down regulation of syringal lignin catabolism|down regulation of syringal lignin degradation|down-regulation of S-lignin catabolic process|down-regulation of syringal lignin breakdown|down-regulation of syringal lignin catabolic process|down-regulation of syringal lignin catabolism|down-regulation of syringal lignin degradation|downregulation of S-lignin catabolic process|downregulation of syringal lignin breakdown|downregulation of syringal lignin catabolic process|downregulation of syringal lignin catabolism|downregulation of syringal lignin degradation|inhibition of S-lignin catabolic process|inhibition of syringal lignin breakdown|inhibition of syringal lignin catabolic process|inhibition of syringal lignin catabolism|inhibition of syringal lignin degradation|negative regulation of S-lignin catabolic process|negative regulation of syringal lignin breakdown|negative regulation of syringal lignin catabolism|negative regulation of syringal lignin degradation http://purl.obolibrary.org/obo/GO_1901470 GO:1901479 biolink:MolecularActivity obsolete benomyl transmembrane transporter activity OBSOLETE. Enables the transfer of benomyl from one side of a membrane to the other. go.json benomyl transporter activity True http://purl.obolibrary.org/obo/GO_1901479 GO:1901477 biolink:BiologicalProcess obsolete benomyl transmembrane transport OBSOLETE. The directed movement of benomyl across a membrane. go.json benomyl membrane transport True http://purl.obolibrary.org/obo/GO_1901477 GO:1901478 biolink:MolecularActivity aminotriazole transmembrane transporter activity Enables the transfer of amitrole from one side of a membrane to the other. go.json aminotriazole transporter activity http://purl.obolibrary.org/obo/GO_1901478 GO:1901475 biolink:BiologicalProcess pyruvate transmembrane transport The directed movement of pyruvate across a membrane. go.json pyruvate membrane transport http://purl.obolibrary.org/obo/GO_1901475 GO:1901476 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901476 GO:1901473 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901473 GO:1901474 biolink:MolecularActivity azole transmembrane transporter activity Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. go.json azole transporter activity http://purl.obolibrary.org/obo/GO_1901474 GO:0035595 biolink:MolecularActivity N-acetylglucosaminylinositol deacetylase activity Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol. EC:3.5.1.103|KEGG_REACTION:R09651|MetaCyc:RXN1G-2|RHEA:26180 go.json 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity|1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity|GlcNAc-Ins deacetylase activity|N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity http://purl.obolibrary.org/obo/GO_0035595 GO:1901482 biolink:BiologicalProcess L-lysine import into vacuole involved in cellular response to nitrogen starvation A L-lysine import into the vacuole that is involved in cellular response to nitrogen starvation. go.json http://purl.obolibrary.org/obo/GO_1901482 GO:1901483 biolink:BiologicalProcess obsolete regulation of transcription factor catabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of transcription factor catabolic process. go.json regulation of proteasome-mediated transcription factor catabolism|regulation of sequence-specific DNA binding transcription factor catabolic process|regulation of transcription factor breakdown|regulation of transcription factor catabolism|regulation of transcription factor degradation True http://purl.obolibrary.org/obo/GO_1901483 GO:0035596 biolink:MolecularActivity methylthiotransferase activity Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. go.json MTTase http://purl.obolibrary.org/obo/GO_0035596 GO:1901480 biolink:MolecularActivity oleate transmembrane transporter activity Enables the transfer of oleate from one side of a membrane to the other. RHEA:33655 go.json oleate transporter activity http://purl.obolibrary.org/obo/GO_1901480 GO:0035597 biolink:MolecularActivity N6-isopentenyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A). go.json i6A methylthiotransferase activity http://purl.obolibrary.org/obo/GO_0035597 GO:1901481 biolink:BiologicalProcess L-glutamate import involved in cellular response to nitrogen starvation Any L-glutamate import that is involved in cellular response to nitrogen starvation. go.json L-glutamate uptake involved in cellular response to nitrogen starvation http://purl.obolibrary.org/obo/GO_1901481 GO:0035598 biolink:MolecularActivity N6-threonylcarbomyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). Reactome:R-HSA-6786571 go.json t6A methylthiotransferase activity http://purl.obolibrary.org/obo/GO_0035598 GO:0035599 biolink:MolecularActivity aspartic acid methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid. RESID:AA0232 go.json http://purl.obolibrary.org/obo/GO_0035599 GO:0035590 biolink:BiologicalProcess purinergic nucleotide receptor signaling pathway The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json P2 receptor signaling pathway|purinergic nucleotide receptor signalling pathway|purinergic receptor signaling pathway|purinergic receptor signalling pathway|purinoceptor signaling pathway http://purl.obolibrary.org/obo/GO_0035590 GO:0035591 biolink:MolecularActivity signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. go.json signaling protein recruiting activity|signaling scaffold activity|signalling adaptor activity http://purl.obolibrary.org/obo/GO_0035591 GO:0035592 biolink:BiologicalProcess establishment of protein localization to extracellular region The directed movement of a protein to a specific location within the extracellular region. go.json establishment of protein localisation in extracellular region|establishment of protein localization in extracellular region http://purl.obolibrary.org/obo/GO_0035592 GO:0035593 biolink:BiologicalProcess positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region. go.json positive regulation of Wnt diffusion|positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region|positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region|positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region|positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region|positive regulation of Wnt signaling range|positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region http://purl.obolibrary.org/obo/GO_0035593 GO:0035594 biolink:MolecularActivity ganglioside binding Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues. go.json http://purl.obolibrary.org/obo/GO_0035594 GO:1901488 biolink:BiologicalProcess obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process OBSOLETE. Negative regulation of transcription factor catabolism that results in positive regulation of the SREBP signaling pathway. go.json positive regulation of SREBP signaling pathway by inhibition of SREBP degradation|positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation|positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolism|positive regulation of SREBP-mediated signaling pathway by negative regulation of transcription factor catabolic process|positive regulation of SREBP-mediated signalling pathway by negative regulation of transcription factor catabolic process True http://purl.obolibrary.org/obo/GO_1901488 GO:1901489 biolink:BiologicalProcess obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process in response to decreased oxygen levels OBSOLETE. Negative regulation of transcription factor catabolism in response to decreased oxygen levels, which results in positive regulation of the SREBP signaling pathway. go.json positive regulation of SREBP signaling by inhibition of SREBP degradation in response to decreased oxygen levels|positive regulation of SREBP signaling by negative regulation of transcription factor catabolism at low oxygen levels|positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation, in response to decreased oxygen|positive regulation of SREBP-mediated signaling pathway in absence of oxygen by negative regulation of transcription factor catabolic process|positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels by negative regulation of transcription factor catabolic process True http://purl.obolibrary.org/obo/GO_1901489 GO:1901486 biolink:BiologicalProcess obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process OBSOLETE. Positive regulation of transcription factor catabolism that results in negative regulation of the SREBP signaling pathway. go.json negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation|negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolism|negative regulation of SREBP-mediated signaling pathway by positive regulation of transcription factor catabolic process|negative regulation of SREBP-mediated signalling pathway by positive regulation of transcription factor catabolic process True http://purl.obolibrary.org/obo/GO_1901486 GO:1901487 biolink:BiologicalProcess obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels OBSOLETE. Positive regulation of transcription factor catabolism in response to increased oxygen levels, which results in negative regulation of the SREBP signaling pathway. go.json negative regulation of SREBP signaling by acceleration of SREBP degradation, in response to increased oxygen levels|negative regulation of SREBP signaling by positive regulation of transcription factor catabolism in response to increased oxygen levels|negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation, in response to elevated oxygen|negative regulation of SREBP-mediated signaling pathway in presence of oxygen by positive regulation of transcription factor catabolic process|negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels by positive regulation of transcription factor catabolic process True http://purl.obolibrary.org/obo/GO_1901487 GO:1901484 biolink:BiologicalProcess obsolete negative regulation of transcription factor catabolic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription factor catabolic process. go.json down regulation of proteasome-mediated transcription factor catabolism|down regulation of sequence-specific DNA binding transcription factor catabolic process|down regulation of transcription factor breakdown|down regulation of transcription factor catabolic process|down regulation of transcription factor catabolism|down regulation of transcription factor degradation|down-regulation of proteasome-mediated transcription factor catabolism|down-regulation of sequence-specific DNA binding transcription factor catabolic process|down-regulation of transcription factor breakdown|down-regulation of transcription factor catabolic process|down-regulation of transcription factor catabolism|down-regulation of transcription factor degradation|downregulation of proteasome-mediated transcription factor catabolism|downregulation of sequence-specific DNA binding transcription factor catabolic process|downregulation of transcription factor breakdown|downregulation of transcription factor catabolic process|downregulation of transcription factor catabolism|downregulation of transcription factor degradation|inhibition of proteasome-mediated transcription factor catabolism|inhibition of sequence-specific DNA binding transcription factor catabolic process|inhibition of transcription factor breakdown|inhibition of transcription factor catabolic process|inhibition of transcription factor catabolism|inhibition of transcription factor degradation|negative regulation of proteasome-mediated transcription factor catabolism|negative regulation of sequence-specific DNA binding transcription factor catabolic process|negative regulation of transcription factor breakdown|negative regulation of transcription factor catabolism|negative regulation of transcription factor degradation True http://purl.obolibrary.org/obo/GO_1901484 GO:1901485 biolink:BiologicalProcess obsolete positive regulation of transcription factor catabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process. go.json activation of proteasome-mediated transcription factor catabolism|activation of sequence-specific DNA binding transcription factor catabolic process|activation of transcription factor breakdown|activation of transcription factor catabolic process|activation of transcription factor catabolism|activation of transcription factor degradation|positive regulation of proteasome-mediated transcription factor catabolism|positive regulation of sequence-specific DNA binding transcription factor catabolic process|positive regulation of transcription factor breakdown|positive regulation of transcription factor catabolism|positive regulation of transcription factor degradation|up regulation of proteasome-mediated transcription factor catabolism|up regulation of sequence-specific DNA binding transcription factor catabolic process|up regulation of transcription factor breakdown|up regulation of transcription factor catabolic process|up regulation of transcription factor catabolism|up regulation of transcription factor degradation|up-regulation of proteasome-mediated transcription factor catabolism|up-regulation of sequence-specific DNA binding transcription factor catabolic process|up-regulation of transcription factor breakdown|up-regulation of transcription factor catabolic process|up-regulation of transcription factor catabolism|up-regulation of transcription factor degradation|upregulation of proteasome-mediated transcription factor catabolism|upregulation of sequence-specific DNA binding transcription factor catabolic process|upregulation of transcription factor breakdown|upregulation of transcription factor catabolic process|upregulation of transcription factor catabolism|upregulation of transcription factor degradation True http://purl.obolibrary.org/obo/GO_1901485 GO:1901493 biolink:BiologicalProcess response to decalin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901493 GO:0035584 biolink:BiologicalProcess calcium-mediated signaling using intracellular calcium source The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. go.json calcium signaling using intracellular calcium source|calcium signalling using intracellular calcium source|calcium-mediated signalling using intracellular calcium source http://purl.obolibrary.org/obo/GO_0035584 GO:0035585 biolink:BiologicalProcess calcium-mediated signaling using extracellular calcium source The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response. go.json calcium signaling using extracellular calcium source|calcium signalling using extracellular calcium source|calcium-mediated signalling using extracellular calcium source|extracellular calcium influx http://purl.obolibrary.org/obo/GO_0035585 GO:1901494 biolink:BiologicalProcess regulation of cysteine metabolic process Any process that modulates the frequency, rate or extent of cysteine metabolic process. go.json regulation of cysteine metabolism http://purl.obolibrary.org/obo/GO_1901494 GO:1901491 biolink:BiologicalProcess negative regulation of lymphangiogenesis Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis. go.json down regulation of lymph vessel formation|down regulation of lymphangiogenesis|down-regulation of lymph vessel formation|down-regulation of lymphangiogenesis|downregulation of lymph vessel formation|downregulation of lymphangiogenesis|inhibition of lymph vessel formation|inhibition of lymphangiogenesis|negative regulation of lymph vessel formation http://purl.obolibrary.org/obo/GO_1901491 GO:0035586 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035586 GO:0035587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035587 GO:1901492 biolink:BiologicalProcess positive regulation of lymphangiogenesis Any process that activates or increases the frequency, rate or extent of lymphangiogenesis. go.json activation of lymph vessel formation|activation of lymphangiogenesis|positive regulation of lymph vessel formation|up regulation of lymph vessel formation|up regulation of lymphangiogenesis|up-regulation of lymph vessel formation|up-regulation of lymphangiogenesis|upregulation of lymph vessel formation|upregulation of lymphangiogenesis http://purl.obolibrary.org/obo/GO_1901492 GO:0035588 biolink:BiologicalProcess G protein-coupled purinergic receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by an extracellular purine or purine derivative binding to its receptor, and ending with the regulation of a downstream cellular process. go.json G-protein coupled purinergic receptor signaling pathway|G-protein coupled purinergic receptor signalling pathway http://purl.obolibrary.org/obo/GO_0035588 GO:1901490 biolink:BiologicalProcess regulation of lymphangiogenesis Any process that modulates the frequency, rate or extent of lymphangiogenesis. go.json regulation of lymph vessel formation http://purl.obolibrary.org/obo/GO_1901490 GO:0035589 biolink:BiologicalProcess G protein-coupled purinergic nucleotide receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. go.json G-protein coupled purinergic nucleotide receptor signaling pathway|G-protein coupled purinergic nucleotide receptor signalling pathway|P2Y receptor signaling pathway http://purl.obolibrary.org/obo/GO_0035589 GO:0035580 biolink:CellularComponent specific granule lumen The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. go.json secondary granule lumen http://purl.obolibrary.org/obo/GO_0035580 GO:0035581 biolink:BiologicalProcess sequestering of extracellular ligand from receptor The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor. go.json extracellular sequestering of receptor ligand|negative regulation of protein bioavailability http://purl.obolibrary.org/obo/GO_0035581 GO:0035582 biolink:BiologicalProcess sequestering of BMP in extracellular matrix Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. go.json BMP sequestration in the ECM|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP|negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein http://purl.obolibrary.org/obo/GO_0035582 GO:0035583 biolink:BiologicalProcess sequestering of TGFbeta in extracellular matrix Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins. go.json negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta|negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta|sequestering of TGFbeta LLC in extracellular matrix|sequestering of TGFbeta large latency complex in extracellular matrix http://purl.obolibrary.org/obo/GO_0035583 GO:1901499 biolink:BiologicalProcess response to hexane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus. go.json http://purl.obolibrary.org/obo/GO_1901499 GO:1901497 biolink:BiologicalProcess response to diphenyl ether Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenyl ether stimulus. go.json http://purl.obolibrary.org/obo/GO_1901497 GO:1901498 biolink:BiologicalProcess response to tetralin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetralin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901498 GO:1901495 biolink:BiologicalProcess negative regulation of cysteine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process. go.json down regulation of cysteine metabolic process|down regulation of cysteine metabolism|down-regulation of cysteine metabolic process|down-regulation of cysteine metabolism|downregulation of cysteine metabolic process|downregulation of cysteine metabolism|inhibition of cysteine metabolic process|inhibition of cysteine metabolism|negative regulation of cysteine metabolism http://purl.obolibrary.org/obo/GO_1901495 GO:1901496 biolink:BiologicalProcess positive regulation of cysteine metabolic process Any process that activates or increases the frequency, rate or extent of cysteine metabolic process. go.json activation of cysteine metabolic process|activation of cysteine metabolism|positive regulation of cysteine metabolism|up regulation of cysteine metabolic process|up regulation of cysteine metabolism|up-regulation of cysteine metabolic process|up-regulation of cysteine metabolism|upregulation of cysteine metabolic process|upregulation of cysteine metabolism http://purl.obolibrary.org/obo/GO_1901496 GO:0035573 biolink:BiologicalProcess N-terminal peptidyl-serine trimethylation The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine. go.json http://purl.obolibrary.org/obo/GO_0035573 gocheck_do_not_annotate GO:0035574 biolink:BiologicalProcess obsolete histone H4-K20 demethylation OBSOLETE. The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone. go.json True http://purl.obolibrary.org/obo/GO_0035574 GO:0035575 biolink:MolecularActivity histone H4K20 demethylase activity Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. Reactome:R-HSA-2172678 go.json histone H4-K20 demethylase activity|histone H4-methyl-lysine-20 demethylase activity|histone H4K20me demethylase activity|histone demethylase activity (H4-K20 specific)|histone demethylase activity (H4K20-specific) http://purl.obolibrary.org/obo/GO_0035575 GO:0035576 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in pronephric field specification The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop. go.json retinoic acid receptor signalling pathway involved in pronephric field specification http://purl.obolibrary.org/obo/GO_0035576 GO:0035577 biolink:CellularComponent azurophil granule membrane The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. go.json primary granule membrane http://purl.obolibrary.org/obo/GO_0035577 GO:0035578 biolink:CellularComponent azurophil granule lumen The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. go.json primary granule lumen http://purl.obolibrary.org/obo/GO_0035578 GO:0035579 biolink:CellularComponent specific granule membrane The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. go.json secondary granule membrane http://purl.obolibrary.org/obo/GO_0035579 GO:0035570 biolink:BiologicalProcess N-terminal peptidyl-serine methylation The methylation of the N-terminal serine of proteins. go.json http://purl.obolibrary.org/obo/GO_0035570 gocheck_do_not_annotate GO:0035571 biolink:BiologicalProcess N-terminal peptidyl-serine monomethylation The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine. go.json http://purl.obolibrary.org/obo/GO_0035571 gocheck_do_not_annotate GO:0035572 biolink:BiologicalProcess N-terminal peptidyl-serine dimethylation The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine. go.json http://purl.obolibrary.org/obo/GO_0035572 gocheck_do_not_annotate GO:0035562 biolink:BiologicalProcess negative regulation of chromatin binding Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. go.json http://purl.obolibrary.org/obo/GO_0035562 gocheck_do_not_annotate GO:0035563 biolink:BiologicalProcess positive regulation of chromatin binding Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. go.json http://purl.obolibrary.org/obo/GO_0035563 gocheck_do_not_annotate GO:0035564 biolink:BiologicalProcess regulation of kidney size Any process that modulates the size of a kidney. go.json http://purl.obolibrary.org/obo/GO_0035564 GO:0035565 biolink:BiologicalProcess regulation of pronephros size Any process that modulates the size of a pronephric kidney. go.json regulation of pronephric kidney size http://purl.obolibrary.org/obo/GO_0035565 GO:0035566 biolink:BiologicalProcess regulation of metanephros size Any process that modulates the size of a metanephric kidney. go.json regulation of metanephric kidney size http://purl.obolibrary.org/obo/GO_0035566 GO:0035567 biolink:BiologicalProcess non-canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. go.json beta-catenin-independent Wnt receptor signaling pathway|non-canonical Wnt receptor signaling pathway|non-canonical Wnt receptor signalling pathway|non-canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0035567 GO:0035568 biolink:BiologicalProcess N-terminal peptidyl-proline methylation The methylation of the N-terminal proline of proteins. RESID:AA0419 go.json http://purl.obolibrary.org/obo/GO_0035568 gocheck_do_not_annotate GO:0035569 biolink:BiologicalProcess obsolete N-terminal peptidyl-proline trimethylation OBSOLETE. The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline. go.json N-terminal peptidyl-proline trimethylation True http://purl.obolibrary.org/obo/GO_0035569 GO:0035560 biolink:MolecularActivity pheophorbidase activity Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a. EC:3.1.1.82|RHEA:32483 go.json PPD activity|phedase activity|pheophoridase activity http://purl.obolibrary.org/obo/GO_0035560 GO:0035561 biolink:BiologicalProcess regulation of chromatin binding Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. go.json http://purl.obolibrary.org/obo/GO_0035561 gocheck_do_not_annotate GO:0035559 biolink:BiologicalProcess obsolete MAPKKK cascade involved in epidermal growth factor receptor signaling OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. go.json MAPKKK cascade involved in epidermal growth factor receptor signaling|MAPKKK cascade involved in epidermal growth factor receptor signalling|MAPKKK cascade involved in signaling from the EGFR True http://purl.obolibrary.org/obo/GO_0035559 GO:0035551 biolink:BiologicalProcess obsolete protein initiator methionine removal involved in protein maturation OBSOLETE. Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein. go.json True http://purl.obolibrary.org/obo/GO_0035551 GO:0035552 biolink:BiologicalProcess oxidative single-stranded DNA demethylation Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. go.json oxidative ssDNA demethylation http://purl.obolibrary.org/obo/GO_0035552 GO:0035553 biolink:BiologicalProcess oxidative single-stranded RNA demethylation Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. go.json oxidative ssRNA demethylation http://purl.obolibrary.org/obo/GO_0035553 GO:0035554 biolink:BiologicalProcess termination of Roundabout signal transduction The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated. go.json http://purl.obolibrary.org/obo/GO_0035554 GO:0035555 biolink:BiologicalProcess obsolete initiation of Roundabout signal transduction OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO). go.json initiation of Roundabout signal transduction True http://purl.obolibrary.org/obo/GO_0035555 GO:0035556 biolink:BiologicalProcess intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. go.json intracellular protein kinase cascade|intracellular signal transduction pathway|intracellular signaling cascade|intracellular signaling chain|intracellular signaling pathway|protein kinase cascade|signal transduction via intracellular signaling cascade|signal transmission via intracellular cascade http://purl.obolibrary.org/obo/GO_0035556 goslim_drosophila GO:0035557 biolink:BiologicalProcess obsolete intracellular signal transduction involved in cell surface receptor linked signaling OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. go.json intracellular signal transduction involved in cell surface receptor linked signaling|intracellular signal transduction involved in cell surface receptor linked signalling|intracellular signaling cascade involved in cell surface receptor linked signaling|intracellular signaling chain involved in cell surface receptor signaling True http://purl.obolibrary.org/obo/GO_0035557 GO:0035558 biolink:BiologicalProcess obsolete phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. go.json PI3K cascade involved in signaling from the insulin receptor|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling|phosphoinositide 3-kinase cascade involved in insulin receptor signaling|phosphoinositide 3-kinase cascade involved in insulin receptor signalling True http://purl.obolibrary.org/obo/GO_0035558 GO:0035550 biolink:CellularComponent urease complex A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). go.json http://purl.obolibrary.org/obo/GO_0035550 GO:0060510 biolink:BiologicalProcess type II pneumocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. go.json granular pneumocyte differentiation|great alveolar cell differentiation|large alveolar cell differentiation http://purl.obolibrary.org/obo/GO_0060510 GO:0060511 biolink:BiologicalProcess obsolete creation of an inductive signal by a mesenchymal cell involved in lung induction OBSOLETE. The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud. go.json True http://purl.obolibrary.org/obo/GO_0060511 GO:0060512 biolink:BiologicalProcess prostate gland morphogenesis The process in which the anatomical structures of a prostate gland are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060512 GO:0060513 biolink:BiologicalProcess prostatic bud formation The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. go.json primary prostate bud formation|prostate ductal budding|prostate gland formation http://purl.obolibrary.org/obo/GO_0060513 GO:0060514 biolink:BiologicalProcess prostate induction The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. go.json http://purl.obolibrary.org/obo/GO_0060514 GO:0060515 biolink:BiologicalProcess prostate field specification The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop. go.json http://purl.obolibrary.org/obo/GO_0060515 GO:0060516 biolink:BiologicalProcess primary prostatic bud elongation The increase in size of the prostatic bud as it forms. go.json prostate bud elongation|prostate bud elongation involved in prostate morphogenesis http://purl.obolibrary.org/obo/GO_0060516 GO:0060517 biolink:BiologicalProcess epithelial cell proliferation involved in prostatic bud elongation The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud. go.json http://purl.obolibrary.org/obo/GO_0060517 GO:0060518 biolink:BiologicalProcess cell migration involved in prostatic bud elongation The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud. go.json http://purl.obolibrary.org/obo/GO_0060518 GO:0060519 biolink:BiologicalProcess cell adhesion involved in prostatic bud elongation The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud. go.json http://purl.obolibrary.org/obo/GO_0060519 GO:0060500 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in lung bud formation OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed. go.json True http://purl.obolibrary.org/obo/GO_0060500 GO:0060501 biolink:BiologicalProcess positive regulation of epithelial cell proliferation involved in lung morphogenesis Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. go.json http://purl.obolibrary.org/obo/GO_0060501 GO:0060502 biolink:BiologicalProcess epithelial cell proliferation involved in lung morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. go.json http://purl.obolibrary.org/obo/GO_0060502 GO:0060503 biolink:BiologicalProcess bud dilation involved in lung branching The process in which a bud in the lung increases radially. go.json bud expansion http://purl.obolibrary.org/obo/GO_0060503 GO:0060504 biolink:BiologicalProcess positive regulation of epithelial cell proliferation involved in lung bud dilation Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially. go.json http://purl.obolibrary.org/obo/GO_0060504 GO:0060505 biolink:BiologicalProcess epithelial cell proliferation involved in lung bud dilation The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud. go.json http://purl.obolibrary.org/obo/GO_0060505 GO:0060506 biolink:BiologicalProcess smoothened signaling pathway involved in lung development The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development. go.json hedgehog signaling pathway involved in lung development|hh signaling pathway involved in lung development|smoothened signalling pathway involved in lung development http://purl.obolibrary.org/obo/GO_0060506 GO:0060507 biolink:BiologicalProcess epidermal growth factor receptor signaling pathway involved in lung development The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development. go.json epidermal growth factor receptor signalling pathway involved in lung development http://purl.obolibrary.org/obo/GO_0060507 GO:0060508 biolink:BiologicalProcess lung basal cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell. go.json pulmonary basal cell differentiation http://purl.obolibrary.org/obo/GO_0060508 GO:0060509 biolink:BiologicalProcess type I pneumocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. go.json membranous pneumocyte differentiation|small alveolar cell differentiation|squamous alveolar cell differentiation http://purl.obolibrary.org/obo/GO_0060509 GO:0060530 biolink:BiologicalProcess smooth muscle cell differentiation involved in prostate glandular acinus development The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus. go.json http://purl.obolibrary.org/obo/GO_0060530 GO:0060531 biolink:BiologicalProcess neuroendocrine cell differentiation involved in prostate gland acinus development The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus. go.json http://purl.obolibrary.org/obo/GO_0060531 GO:0060532 biolink:BiologicalProcess bronchus cartilage development The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. go.json pulmonary cartilage development http://purl.obolibrary.org/obo/GO_0060532 GO:0060533 biolink:BiologicalProcess bronchus cartilage morphogenesis The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. go.json http://purl.obolibrary.org/obo/GO_0060533 GO:0060534 biolink:BiologicalProcess trachea cartilage development The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. go.json http://purl.obolibrary.org/obo/GO_0060534 GO:0060535 biolink:BiologicalProcess trachea cartilage morphogenesis The process in which the anatomical structures of cartilage in the trachea are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060535 GO:0060536 biolink:BiologicalProcess cartilage morphogenesis The process in which the anatomical structures of cartilage are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060536 GO:0060537 biolink:BiologicalProcess muscle tissue development The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. go.json http://purl.obolibrary.org/obo/GO_0060537 GO:0060538 biolink:BiologicalProcess skeletal muscle organ development The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. go.json http://purl.obolibrary.org/obo/GO_0060538 GO:0060539 biolink:BiologicalProcess diaphragm development The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. go.json http://purl.obolibrary.org/obo/GO_0060539 GO:0060520 biolink:BiologicalProcess activation of prostate induction by androgen receptor signaling pathway The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. go.json activation of prostate induction by androgen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060520 GO:0060521 biolink:BiologicalProcess mesenchymal-epithelial cell signaling involved in prostate induction Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate. go.json mesenchymal-epithelial cell signalling involved in prostate induction http://purl.obolibrary.org/obo/GO_0060521 GO:0060522 biolink:BiologicalProcess inductive mesenchymal to epithelial cell signaling Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells. go.json inductive mesenchymal to epithelial cell signalling http://purl.obolibrary.org/obo/GO_0060522 GO:0060523 biolink:BiologicalProcess prostate epithelial cord elongation The developmental growth process in which solid chords of prostate epithelium increase in length. go.json http://purl.obolibrary.org/obo/GO_0060523 GO:0060524 biolink:BiologicalProcess dichotomous subdivision of prostate epithelial cord terminal unit The process in which a prostate epithelial cord bifurcates at its end. go.json prostate epithelial cord bifurcation http://purl.obolibrary.org/obo/GO_0060524 GO:0060525 biolink:BiologicalProcess prostate glandular acinus development The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. go.json http://purl.obolibrary.org/obo/GO_0060525 GO:0060526 biolink:BiologicalProcess prostate glandular acinus morphogenesis The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland. go.json http://purl.obolibrary.org/obo/GO_0060526 GO:0060527 biolink:BiologicalProcess prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini. go.json http://purl.obolibrary.org/obo/GO_0060527 GO:0060528 biolink:BiologicalProcess secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate. go.json http://purl.obolibrary.org/obo/GO_0060528 GO:0060529 biolink:BiologicalProcess squamous basal epithelial stem cell differentiation involved in prostate gland acinus development The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate. go.json http://purl.obolibrary.org/obo/GO_0060529 GO:1901408 biolink:BiologicalProcess obsolete negative regulation of phosphorylation of RNA polymerase II C-terminal domain OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. go.json down regulation of CTD domain phosphorylation of RNA polymerase II|down regulation of generation of II(0) form of RNA polymerase II|down regulation of generation of hyperphosphorylated CTD of RNA polymerase II|down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|down regulation of phosphorylation of RNA polymerase II C-terminal domain|down-regulation of CTD domain phosphorylation of RNA polymerase II|down-regulation of generation of II(0) form of RNA polymerase II|down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II|down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|down-regulation of phosphorylation of RNA polymerase II C-terminal domain|downregulation of CTD domain phosphorylation of RNA polymerase II|downregulation of generation of II(0) form of RNA polymerase II|downregulation of generation of hyperphosphorylated CTD of RNA polymerase II|downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain|downregulation of phosphorylation of RNA polymerase II C-terminal domain|inhibition of CTD domain phosphorylation of RNA polymerase II|inhibition of generation of II(0) form of RNA polymerase II|inhibition of generation of hyperphosphorylated CTD of RNA polymerase II|inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain|inhibition of phosphorylation of RNA polymerase II C-terminal domain|negative regulation of CTD domain phosphorylation of RNA polymerase II|negative regulation of generation of II(0) form of RNA polymerase II|negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II|negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain True http://purl.obolibrary.org/obo/GO_1901408 GO:1901409 biolink:BiologicalProcess obsolete positive regulation of phosphorylation of RNA polymerase II C-terminal domain OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. go.json activation of CTD domain phosphorylation of RNA polymerase II|activation of generation of II(0) form of RNA polymerase II|activation of generation of hyperphosphorylated CTD of RNA polymerase II|activation of hyperphosphorylation of RNA polymerase II C-terminal domain|activation of phosphorylation of RNA polymerase II C-terminal domain|positive regulation of CTD domain phosphorylation of RNA polymerase II|positive regulation of generation of II(0) form of RNA polymerase II|positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II|positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|up regulation of CTD domain phosphorylation of RNA polymerase II|up regulation of generation of II(0) form of RNA polymerase II|up regulation of generation of hyperphosphorylated CTD of RNA polymerase II|up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|up regulation of phosphorylation of RNA polymerase II C-terminal domain|up-regulation of CTD domain phosphorylation of RNA polymerase II|up-regulation of generation of II(0) form of RNA polymerase II|up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II|up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|up-regulation of phosphorylation of RNA polymerase II C-terminal domain|upregulation of CTD domain phosphorylation of RNA polymerase II|upregulation of generation of II(0) form of RNA polymerase II|upregulation of generation of hyperphosphorylated CTD of RNA polymerase II|upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain|upregulation of phosphorylation of RNA polymerase II C-terminal domain True http://purl.obolibrary.org/obo/GO_1901409 GO:1901406 biolink:BiologicalProcess positive regulation of tetrapyrrole catabolic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process. go.json activation of tetrapyrrole breakdown|activation of tetrapyrrole catabolic process|activation of tetrapyrrole catabolism|activation of tetrapyrrole degradation|positive regulation of tetrapyrrole breakdown|positive regulation of tetrapyrrole catabolism|positive regulation of tetrapyrrole degradation|up regulation of tetrapyrrole breakdown|up regulation of tetrapyrrole catabolic process|up regulation of tetrapyrrole catabolism|up regulation of tetrapyrrole degradation|up-regulation of tetrapyrrole breakdown|up-regulation of tetrapyrrole catabolic process|up-regulation of tetrapyrrole catabolism|up-regulation of tetrapyrrole degradation|upregulation of tetrapyrrole breakdown|upregulation of tetrapyrrole catabolic process|upregulation of tetrapyrrole catabolism|upregulation of tetrapyrrole degradation http://purl.obolibrary.org/obo/GO_1901406 GO:1901407 biolink:BiologicalProcess obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain OBSOLETE. Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. go.json regulation of CTD domain phosphorylation of RNA polymerase II|regulation of generation of II(0) form of RNA polymerase II|regulation of generation of hyperphosphorylated CTD of RNA polymerase II|regulation of hyperphosphorylation of RNA polymerase II C-terminal domain True http://purl.obolibrary.org/obo/GO_1901407 GO:1901404 biolink:BiologicalProcess regulation of tetrapyrrole catabolic process Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process. go.json regulation of tetrapyrrole breakdown|regulation of tetrapyrrole catabolism|regulation of tetrapyrrole degradation http://purl.obolibrary.org/obo/GO_1901404 GO:1901405 biolink:BiologicalProcess negative regulation of tetrapyrrole catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process. go.json down regulation of tetrapyrrole breakdown|down regulation of tetrapyrrole catabolic process|down regulation of tetrapyrrole catabolism|down regulation of tetrapyrrole degradation|down-regulation of tetrapyrrole breakdown|down-regulation of tetrapyrrole catabolic process|down-regulation of tetrapyrrole catabolism|down-regulation of tetrapyrrole degradation|downregulation of tetrapyrrole breakdown|downregulation of tetrapyrrole catabolic process|downregulation of tetrapyrrole catabolism|downregulation of tetrapyrrole degradation|inhibition of tetrapyrrole breakdown|inhibition of tetrapyrrole catabolic process|inhibition of tetrapyrrole catabolism|inhibition of tetrapyrrole degradation|negative regulation of tetrapyrrole breakdown|negative regulation of tetrapyrrole catabolism|negative regulation of tetrapyrrole degradation http://purl.obolibrary.org/obo/GO_1901405 GO:1901402 biolink:BiologicalProcess negative regulation of tetrapyrrole metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process. go.json down regulation of tetrapyrrole metabolic process|down regulation of tetrapyrrole metabolism|down-regulation of tetrapyrrole metabolic process|down-regulation of tetrapyrrole metabolism|downregulation of tetrapyrrole metabolic process|downregulation of tetrapyrrole metabolism|inhibition of tetrapyrrole metabolic process|inhibition of tetrapyrrole metabolism|negative regulation of tetrapyrrole metabolism http://purl.obolibrary.org/obo/GO_1901402 GO:1901403 biolink:BiologicalProcess positive regulation of tetrapyrrole metabolic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process. go.json activation of tetrapyrrole metabolic process|activation of tetrapyrrole metabolism|positive regulation of tetrapyrrole metabolism|up regulation of tetrapyrrole metabolic process|up regulation of tetrapyrrole metabolism|up-regulation of tetrapyrrole metabolic process|up-regulation of tetrapyrrole metabolism|upregulation of tetrapyrrole metabolic process|upregulation of tetrapyrrole metabolism http://purl.obolibrary.org/obo/GO_1901403 GO:1901400 biolink:BiologicalProcess positive regulation of transforming growth factor beta3 activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation. go.json activation of TGF-beta 3 activation|activation of TGFB3 activation|activation of TGFbeta 3 activation|activation of transforming growth factor beta3 activation|positive regulation of TGF-beta 3 activation|positive regulation of TGFB3 activation|positive regulation of TGFbeta 3 activation|up regulation of TGF-beta 3 activation|up regulation of TGFB3 activation|up regulation of TGFbeta 3 activation|up regulation of transforming growth factor beta3 activation|up-regulation of TGF-beta 3 activation|up-regulation of TGFB3 activation|up-regulation of TGFbeta 3 activation|up-regulation of transforming growth factor beta3 activation|upregulation of TGF-beta 3 activation|upregulation of TGFB3 activation|upregulation of TGFbeta 3 activation|upregulation of transforming growth factor beta3 activation http://purl.obolibrary.org/obo/GO_1901400 GO:1901401 biolink:BiologicalProcess regulation of tetrapyrrole metabolic process Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. go.json regulation of tetrapyrrole metabolism http://purl.obolibrary.org/obo/GO_1901401 GO:0060550 biolink:BiologicalProcess positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0060550 gocheck_do_not_annotate GO:0060551 biolink:BiologicalProcess regulation of fructose 1,6-bisphosphate metabolic process Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. go.json http://purl.obolibrary.org/obo/GO_0060551 GO:0060552 biolink:BiologicalProcess positive regulation of fructose 1,6-bisphosphate metabolic process Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. go.json http://purl.obolibrary.org/obo/GO_0060552 GO:0060553 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060553 GO:0060554 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060554 GO:0060555 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060555 GO:0060556 biolink:BiologicalProcess regulation of vitamin D biosynthetic process Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json http://purl.obolibrary.org/obo/GO_0060556 GO:0060557 biolink:BiologicalProcess positive regulation of vitamin D biosynthetic process Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json http://purl.obolibrary.org/obo/GO_0060557 GO:0060558 biolink:BiologicalProcess regulation of calcidiol 1-monooxygenase activity Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0060558 gocheck_do_not_annotate GO:0060559 biolink:BiologicalProcess positive regulation of calcidiol 1-monooxygenase activity Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0060559 gocheck_do_not_annotate GO:1901419 biolink:BiologicalProcess regulation of response to alcohol Any process that modulates the frequency, rate or extent of response to alcohol. go.json http://purl.obolibrary.org/obo/GO_1901419 GO:1901417 biolink:BiologicalProcess negative regulation of response to ethanol Any process that stops, prevents or reduces the frequency, rate or extent of response to ethanol. go.json down regulation of response to ethanol|down-regulation of response to ethanol|downregulation of response to ethanol|inhibition of response to ethanol http://purl.obolibrary.org/obo/GO_1901417 GO:1901418 biolink:BiologicalProcess positive regulation of response to ethanol Any process that activates or increases the frequency, rate or extent of response to ethanol. go.json activation of response to ethanol|up regulation of response to ethanol|up-regulation of response to ethanol|upregulation of response to ethanol http://purl.obolibrary.org/obo/GO_1901418 GO:1901415 biolink:BiologicalProcess positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA. go.json activation of tetrapyrrole anabolism from glycine and succinyl-CoA|activation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|activation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|activation of tetrapyrrole formation from glycine and succinyl-CoA|activation of tetrapyrrole synthesis from glycine and succinyl-CoA|positive regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|positive regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|positive regulation of tetrapyrrole formation from glycine and succinyl-CoA|positive regulation of tetrapyrrole synthesis from glycine and succinyl-CoA|up regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|up regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|up regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|up regulation of tetrapyrrole formation from glycine and succinyl-CoA|up regulation of tetrapyrrole synthesis from glycine and succinyl-CoA|up-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|up-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|up-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|up-regulation of tetrapyrrole formation from glycine and succinyl-CoA|up-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA|upregulation of tetrapyrrole anabolism from glycine and succinyl-CoA|upregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|upregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|upregulation of tetrapyrrole formation from glycine and succinyl-CoA|upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA http://purl.obolibrary.org/obo/GO_1901415 GO:1901416 biolink:BiologicalProcess regulation of response to ethanol Any process that modulates the frequency, rate or extent of response to ethanol. go.json http://purl.obolibrary.org/obo/GO_1901416 GO:1901413 biolink:BiologicalProcess regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA. go.json regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|regulation of tetrapyrrole formation from glycine and succinyl-CoA|regulation of tetrapyrrole synthesis from glycine and succinyl-CoA http://purl.obolibrary.org/obo/GO_1901413 GO:1901414 biolink:BiologicalProcess negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA. go.json down regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|down regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|down regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|down regulation of tetrapyrrole formation from glycine and succinyl-CoA|down regulation of tetrapyrrole synthesis from glycine and succinyl-CoA|down-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|down-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|down-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|down-regulation of tetrapyrrole formation from glycine and succinyl-CoA|down-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA|downregulation of tetrapyrrole anabolism from glycine and succinyl-CoA|downregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|downregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|downregulation of tetrapyrrole formation from glycine and succinyl-CoA|downregulation of tetrapyrrole synthesis from glycine and succinyl-CoA|inhibition of tetrapyrrole anabolism from glycine and succinyl-CoA|inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA|inhibition of tetrapyrrole biosynthetic process from glycine and succinyl-CoA|inhibition of tetrapyrrole formation from glycine and succinyl-CoA|inhibition of tetrapyrrole synthesis from glycine and succinyl-CoA|negative regulation of tetrapyrrole anabolism from glycine and succinyl-CoA|negative regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA|negative regulation of tetrapyrrole formation from glycine and succinyl-CoA|negative regulation of tetrapyrrole synthesis from glycine and succinyl-CoA http://purl.obolibrary.org/obo/GO_1901414 GO:1901411 biolink:BiologicalProcess negative regulation of tetrapyrrole biosynthetic process from glutamate Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate. go.json down regulation of tetrapyrrole anabolism from glutamate|down regulation of tetrapyrrole biosynthesis from glutamate|down regulation of tetrapyrrole biosynthetic process from glutamate|down regulation of tetrapyrrole formation from glutamate|down regulation of tetrapyrrole synthesis from glutamate|down-regulation of tetrapyrrole anabolism from glutamate|down-regulation of tetrapyrrole biosynthesis from glutamate|down-regulation of tetrapyrrole biosynthetic process from glutamate|down-regulation of tetrapyrrole formation from glutamate|down-regulation of tetrapyrrole synthesis from glutamate|downregulation of tetrapyrrole anabolism from glutamate|downregulation of tetrapyrrole biosynthesis from glutamate|downregulation of tetrapyrrole biosynthetic process from glutamate|downregulation of tetrapyrrole formation from glutamate|downregulation of tetrapyrrole synthesis from glutamate|inhibition of tetrapyrrole anabolism from glutamate|inhibition of tetrapyrrole biosynthesis from glutamate|inhibition of tetrapyrrole biosynthetic process from glutamate|inhibition of tetrapyrrole formation from glutamate|inhibition of tetrapyrrole synthesis from glutamate|negative regulation of tetrapyrrole anabolism from glutamate|negative regulation of tetrapyrrole biosynthesis from glutamate|negative regulation of tetrapyrrole formation from glutamate|negative regulation of tetrapyrrole synthesis from glutamate http://purl.obolibrary.org/obo/GO_1901411 GO:1901412 biolink:BiologicalProcess positive regulation of tetrapyrrole biosynthetic process from glutamate Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate. go.json activation of tetrapyrrole anabolism from glutamate|activation of tetrapyrrole biosynthesis from glutamate|activation of tetrapyrrole biosynthetic process from glutamate|activation of tetrapyrrole formation from glutamate|activation of tetrapyrrole synthesis from glutamate|positive regulation of tetrapyrrole anabolism from glutamate|positive regulation of tetrapyrrole biosynthesis from glutamate|positive regulation of tetrapyrrole formation from glutamate|positive regulation of tetrapyrrole synthesis from glutamate|up regulation of tetrapyrrole anabolism from glutamate|up regulation of tetrapyrrole biosynthesis from glutamate|up regulation of tetrapyrrole biosynthetic process from glutamate|up regulation of tetrapyrrole formation from glutamate|up regulation of tetrapyrrole synthesis from glutamate|up-regulation of tetrapyrrole anabolism from glutamate|up-regulation of tetrapyrrole biosynthesis from glutamate|up-regulation of tetrapyrrole biosynthetic process from glutamate|up-regulation of tetrapyrrole formation from glutamate|up-regulation of tetrapyrrole synthesis from glutamate|upregulation of tetrapyrrole anabolism from glutamate|upregulation of tetrapyrrole biosynthesis from glutamate|upregulation of tetrapyrrole biosynthetic process from glutamate|upregulation of tetrapyrrole formation from glutamate|upregulation of tetrapyrrole synthesis from glutamate http://purl.obolibrary.org/obo/GO_1901412 GO:1901410 biolink:BiologicalProcess regulation of tetrapyrrole biosynthetic process from glutamate Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate. go.json regulation of tetrapyrrole anabolism from glutamate|regulation of tetrapyrrole biosynthesis from glutamate|regulation of tetrapyrrole formation from glutamate|regulation of tetrapyrrole synthesis from glutamate http://purl.obolibrary.org/obo/GO_1901410 GO:0060540 biolink:BiologicalProcess diaphragm morphogenesis The process in which the anatomical structures of the diaphragm are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060540 GO:0060541 biolink:BiologicalProcess respiratory system development The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. go.json http://purl.obolibrary.org/obo/GO_0060541 goslim_drosophila GO:0060542 biolink:BiologicalProcess regulation of strand invasion Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. go.json http://purl.obolibrary.org/obo/GO_0060542 GO:0060543 biolink:BiologicalProcess negative regulation of strand invasion Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. go.json negative regulation of D-loop biosynthesis|negative regulation of D-loop formation|negative regulation of Rad51-mediated strand invasion http://purl.obolibrary.org/obo/GO_0060543 GO:0060544 biolink:BiologicalProcess regulation of necroptotic process Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. go.json regulation of necroptosis http://purl.obolibrary.org/obo/GO_0060544 GO:0060545 biolink:BiologicalProcess positive regulation of necroptotic process Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. go.json positive regulation of necroptosis http://purl.obolibrary.org/obo/GO_0060545 GO:0060546 biolink:BiologicalProcess negative regulation of necroptotic process Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. go.json negative regulation of necroptosis http://purl.obolibrary.org/obo/GO_0060546 GO:0060547 biolink:BiologicalProcess obsolete negative regulation of necrotic cell death OBSOLETE. Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. go.json True http://purl.obolibrary.org/obo/GO_0060547 GO:0060548 biolink:BiologicalProcess obsolete negative regulation of cell death OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. go.json True http://purl.obolibrary.org/obo/GO_0060548 GO:0060549 biolink:BiologicalProcess regulation of fructose 1,6-bisphosphate 1-phosphatase activity Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0060549 gocheck_do_not_annotate GO:1901428 biolink:BiologicalProcess regulation of syringal lignin biosynthetic process Any process that modulates the frequency, rate or extent of syringal lignin biosynthetic process. go.json regulation of S-lignin biosynthetic process|regulation of syringal lignin anabolism|regulation of syringal lignin biosynthesis|regulation of syringal lignin formation|regulation of syringal lignin synthesis http://purl.obolibrary.org/obo/GO_1901428 GO:1901429 biolink:BiologicalProcess negative regulation of syringal lignin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin biosynthetic process. go.json down regulation of S-lignin biosynthetic process|down regulation of syringal lignin anabolism|down regulation of syringal lignin biosynthesis|down regulation of syringal lignin biosynthetic process|down regulation of syringal lignin formation|down regulation of syringal lignin synthesis|down-regulation of S-lignin biosynthetic process|down-regulation of syringal lignin anabolism|down-regulation of syringal lignin biosynthesis|down-regulation of syringal lignin biosynthetic process|down-regulation of syringal lignin formation|down-regulation of syringal lignin synthesis|downregulation of S-lignin biosynthetic process|downregulation of syringal lignin anabolism|downregulation of syringal lignin biosynthesis|downregulation of syringal lignin biosynthetic process|downregulation of syringal lignin formation|downregulation of syringal lignin synthesis|inhibition of S-lignin biosynthetic process|inhibition of syringal lignin anabolism|inhibition of syringal lignin biosynthesis|inhibition of syringal lignin biosynthetic process|inhibition of syringal lignin formation|inhibition of syringal lignin synthesis|negative regulation of S-lignin biosynthetic process|negative regulation of syringal lignin anabolism|negative regulation of syringal lignin biosynthesis|negative regulation of syringal lignin formation|negative regulation of syringal lignin synthesis http://purl.obolibrary.org/obo/GO_1901429 GO:1901426 biolink:BiologicalProcess response to furfural Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus. go.json http://purl.obolibrary.org/obo/GO_1901426 GO:1901427 biolink:BiologicalProcess response to propan-1-ol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus. go.json http://purl.obolibrary.org/obo/GO_1901427 GO:1901424 biolink:BiologicalProcess response to toluene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus. go.json http://purl.obolibrary.org/obo/GO_1901424 GO:1901425 biolink:BiologicalProcess response to formic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1901425 GO:1901422 biolink:BiologicalProcess response to butan-1-ol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus. go.json process resulting in tolerance to butan-1-ol http://purl.obolibrary.org/obo/GO_1901422 GO:1901423 biolink:BiologicalProcess response to benzene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus. go.json http://purl.obolibrary.org/obo/GO_1901423 GO:1901420 biolink:BiologicalProcess negative regulation of response to alcohol Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol. go.json down regulation of response to alcohol|down-regulation of response to alcohol|downregulation of response to alcohol|inhibition of response to alcohol http://purl.obolibrary.org/obo/GO_1901420 GO:0060570 biolink:BiologicalProcess negative regulation of peptide hormone processing Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone. go.json http://purl.obolibrary.org/obo/GO_0060570 GO:1901421 biolink:BiologicalProcess positive regulation of response to alcohol Any process that activates or increases the frequency, rate or extent of response to alcohol. go.json activation of response to alcohol|up regulation of response to alcohol|up-regulation of response to alcohol|upregulation of response to alcohol http://purl.obolibrary.org/obo/GO_1901421 GO:0060571 biolink:BiologicalProcess morphogenesis of an epithelial fold The morphogenetic process in which an epithelial sheet bends along a linear axis. go.json epithelial folding|folding of an epithelial sheet http://purl.obolibrary.org/obo/GO_0060571 GO:0060572 biolink:BiologicalProcess morphogenesis of an epithelial bud The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. go.json http://purl.obolibrary.org/obo/GO_0060572 GO:0060573 biolink:BiologicalProcess cell fate specification involved in pattern specification The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. go.json http://purl.obolibrary.org/obo/GO_0060573 GO:0060574 biolink:BiologicalProcess intestinal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. go.json http://purl.obolibrary.org/obo/GO_0060574 GO:0060575 biolink:BiologicalProcess intestinal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. go.json http://purl.obolibrary.org/obo/GO_0060575 GO:0060576 biolink:BiologicalProcess intestinal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060576 GO:0060577 biolink:BiologicalProcess pulmonary vein morphogenesis The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. go.json pulmonary venous blood vessel morphogenesis http://purl.obolibrary.org/obo/GO_0060577 GO:0060578 biolink:BiologicalProcess superior vena cava morphogenesis The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. go.json http://purl.obolibrary.org/obo/GO_0060578 GO:0060579 biolink:BiologicalProcess ventral spinal cord interneuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. go.json http://purl.obolibrary.org/obo/GO_0060579 GO:1901439 biolink:BiologicalProcess positive regulation of toluene metabolic process Any process that activates or increases the frequency, rate or extent of toluene metabolic process. go.json activation of methylbenzene metabolic process|activation of methylbenzene metabolism|activation of toluene metabolic process|activation of toluene metabolism|positive regulation of methylbenzene metabolic process|positive regulation of methylbenzene metabolism|positive regulation of toluene metabolism|up regulation of methylbenzene metabolic process|up regulation of methylbenzene metabolism|up regulation of toluene metabolic process|up regulation of toluene metabolism|up-regulation of methylbenzene metabolic process|up-regulation of methylbenzene metabolism|up-regulation of toluene metabolic process|up-regulation of toluene metabolism|upregulation of methylbenzene metabolic process|upregulation of methylbenzene metabolism|upregulation of toluene metabolic process|upregulation of toluene metabolism http://purl.obolibrary.org/obo/GO_1901439 GO:1901437 biolink:BiologicalProcess regulation of toluene metabolic process Any process that modulates the frequency, rate or extent of toluene metabolic process. go.json regulation of methylbenzene metabolic process|regulation of methylbenzene metabolism|regulation of toluene metabolism http://purl.obolibrary.org/obo/GO_1901437 GO:1901438 biolink:BiologicalProcess negative regulation of toluene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of toluene metabolic process. go.json down regulation of methylbenzene metabolic process|down regulation of methylbenzene metabolism|down regulation of toluene metabolic process|down regulation of toluene metabolism|down-regulation of methylbenzene metabolic process|down-regulation of methylbenzene metabolism|down-regulation of toluene metabolic process|down-regulation of toluene metabolism|downregulation of methylbenzene metabolic process|downregulation of methylbenzene metabolism|downregulation of toluene metabolic process|downregulation of toluene metabolism|inhibition of methylbenzene metabolic process|inhibition of methylbenzene metabolism|inhibition of toluene metabolic process|inhibition of toluene metabolism|negative regulation of methylbenzene metabolic process|negative regulation of methylbenzene metabolism|negative regulation of toluene metabolism http://purl.obolibrary.org/obo/GO_1901438 GO:1901435 biolink:BiologicalProcess negative regulation of toluene catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process. go.json down regulation of toluene breakdown|down regulation of toluene catabolic process|down regulation of toluene catabolism|down regulation of toluene degradation|down-regulation of toluene breakdown|down-regulation of toluene catabolic process|down-regulation of toluene catabolism|down-regulation of toluene degradation|downregulation of toluene breakdown|downregulation of toluene catabolic process|downregulation of toluene catabolism|downregulation of toluene degradation|inhibition of toluene breakdown|inhibition of toluene catabolic process|inhibition of toluene catabolism|inhibition of toluene degradation|negative regulation of toluene breakdown|negative regulation of toluene catabolism|negative regulation of toluene degradation http://purl.obolibrary.org/obo/GO_1901435 GO:1901436 biolink:BiologicalProcess positive regulation of toluene catabolic process Any process that activates or increases the frequency, rate or extent of toluene catabolic process. go.json activation of toluene breakdown|activation of toluene catabolic process|activation of toluene catabolism|activation of toluene degradation|positive regulation of toluene breakdown|positive regulation of toluene catabolism|positive regulation of toluene degradation|up regulation of toluene breakdown|up regulation of toluene catabolic process|up regulation of toluene catabolism|up regulation of toluene degradation|up-regulation of toluene breakdown|up-regulation of toluene catabolic process|up-regulation of toluene catabolism|up-regulation of toluene degradation|upregulation of toluene breakdown|upregulation of toluene catabolic process|upregulation of toluene catabolism|upregulation of toluene degradation http://purl.obolibrary.org/obo/GO_1901436 GO:1901433 biolink:BiologicalProcess positive regulation of response to cycloalkane Any process that activates or increases the frequency, rate or extent of response to cycloalkane. go.json activation of response to cycloalkane|up regulation of response to cycloalkane|up-regulation of response to cycloalkane|upregulation of response to cycloalkane http://purl.obolibrary.org/obo/GO_1901433 GO:1901434 biolink:BiologicalProcess regulation of toluene catabolic process Any process that modulates the frequency, rate or extent of toluene catabolic process. go.json regulation of toluene breakdown|regulation of toluene catabolism|regulation of toluene degradation http://purl.obolibrary.org/obo/GO_1901434 GO:1901431 biolink:BiologicalProcess regulation of response to cycloalkane Any process that modulates the frequency, rate or extent of response to cycloalkane. go.json http://purl.obolibrary.org/obo/GO_1901431 GO:1901432 biolink:BiologicalProcess negative regulation of response to cycloalkane Any process that stops, prevents or reduces the frequency, rate or extent of response to cycloalkane. go.json down regulation of response to cycloalkane|down-regulation of response to cycloalkane|downregulation of response to cycloalkane|inhibition of response to cycloalkane http://purl.obolibrary.org/obo/GO_1901432 GO:0060560 biolink:BiologicalProcess developmental growth involved in morphogenesis The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. go.json differential growth http://purl.obolibrary.org/obo/GO_0060560 GO:1901430 biolink:BiologicalProcess positive regulation of syringal lignin biosynthetic process Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process. go.json activation of S-lignin biosynthetic process|activation of syringal lignin anabolism|activation of syringal lignin biosynthesis|activation of syringal lignin biosynthetic process|activation of syringal lignin formation|activation of syringal lignin synthesis|positive regulation of S-lignin biosynthetic process|positive regulation of syringal lignin anabolism|positive regulation of syringal lignin biosynthesis|positive regulation of syringal lignin formation|positive regulation of syringal lignin synthesis|up regulation of S-lignin biosynthetic process|up regulation of syringal lignin anabolism|up regulation of syringal lignin biosynthesis|up regulation of syringal lignin biosynthetic process|up regulation of syringal lignin formation|up regulation of syringal lignin synthesis|up-regulation of S-lignin biosynthetic process|up-regulation of syringal lignin anabolism|up-regulation of syringal lignin biosynthesis|up-regulation of syringal lignin biosynthetic process|up-regulation of syringal lignin formation|up-regulation of syringal lignin synthesis|upregulation of S-lignin biosynthetic process|upregulation of syringal lignin anabolism|upregulation of syringal lignin biosynthesis|upregulation of syringal lignin biosynthetic process|upregulation of syringal lignin formation|upregulation of syringal lignin synthesis http://purl.obolibrary.org/obo/GO_1901430 GO:0060561 biolink:BiologicalProcess apoptotic process involved in morphogenesis Any apoptotic process that contributes to the shaping of an anatomical structure. go.json apoptosis involved in development|apoptosis involved in morphogenesis|morphogenetic apoptosis http://purl.obolibrary.org/obo/GO_0060561 GO:0060562 biolink:BiologicalProcess epithelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. go.json http://purl.obolibrary.org/obo/GO_0060562 GO:0060563 biolink:BiologicalProcess neuroepithelial cell differentiation The process in which epiblast cells acquire specialized features of neuroepithelial cells. go.json http://purl.obolibrary.org/obo/GO_0060563 GO:0060564 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060564 GO:0060565 biolink:BiologicalProcess obsolete inhibition of APC-Cdc20 complex activity OBSOLETE. Any process that prevents the activation of APC-Cdc20 complex activity regulating the mitotic cell cycle. go.json inhibition of APC activity during mitotic cell cycle|inhibition of APC-Cdc20 complex activity|inhibition of APC/C activity during mitotic cell cycle|inhibition of cyclosome activity during mitotic cell cycle|inhibition of mitotic anaphase-promoting complex activity True http://purl.obolibrary.org/obo/GO_0060565 GO:0060566 biolink:BiologicalProcess positive regulation of termination of DNA-templated transcription Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. go.json positive regulation of DNA-dependent transcription, termination|positive regulation of DNA-templated transcription, termination|positive regulation of termination of DNA-dependent transcription|positive regulation of transcription termination, DNA-dependent http://purl.obolibrary.org/obo/GO_0060566 GO:0060567 biolink:BiologicalProcess negative regulation of termination of DNA-templated transcription Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. go.json negative regulation of DNA-dependent transcription, termination|negative regulation of DNA-templated transcription, termination|negative regulation of termination of DNA-dependent transcription|negative regulation of transcription termination, DNA-dependent http://purl.obolibrary.org/obo/GO_0060567 GO:0060568 biolink:BiologicalProcess regulation of peptide hormone processing Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone. go.json http://purl.obolibrary.org/obo/GO_0060568 GO:0060569 biolink:BiologicalProcess positive regulation of peptide hormone processing Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone. go.json http://purl.obolibrary.org/obo/GO_0060569 GO:0035702 biolink:BiologicalProcess monocyte homeostasis The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0035702 GO:0035703 biolink:BiologicalProcess monocyte migration into blood stream The movement of a monocyte from the bone marrow to the blood stream. go.json release of monocytes into circulation http://purl.obolibrary.org/obo/GO_0035703 GO:0035704 biolink:BiologicalProcess helper T cell chemotaxis The directed movement of a helper T cell in response to an external stimulus. go.json T-helper cell chemotaxis http://purl.obolibrary.org/obo/GO_0035704 GO:0035705 biolink:BiologicalProcess T-helper 17 cell chemotaxis The directed movement of a T-helper 17 cell in response to an external stimulus. go.json Th17 cell chemotaxis http://purl.obolibrary.org/obo/GO_0035705 GO:0035706 biolink:BiologicalProcess T-helper 1 cell chemotaxis The directed movement of a T-helper 1 cell in response to an external stimulus. go.json Th1 cell chemotaxis http://purl.obolibrary.org/obo/GO_0035706 GO:0035707 biolink:BiologicalProcess T-helper 2 cell chemotaxis The directed movement of a T-helper 2 cell in response to an external stimulus. go.json Th2 cell chemotaxis http://purl.obolibrary.org/obo/GO_0035707 GO:0035708 biolink:BiologicalProcess interleukin-4-dependent isotype switching to IgE isotypes The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4). go.json IL-4-dependent isotype switching to IgE isotypes http://purl.obolibrary.org/obo/GO_0035708 GO:0035709 biolink:BiologicalProcess memory T cell activation The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json http://purl.obolibrary.org/obo/GO_0035709 GO:0035700 biolink:BiologicalProcess astrocyte chemotaxis The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_0035700 GO:0035701 biolink:BiologicalProcess hematopoietic stem cell migration The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. go.json hemopoietic stem cell migration http://purl.obolibrary.org/obo/GO_0035701 GO:1901806 biolink:BiologicalProcess beta-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucoside. go.json beta-glucoside anabolism|beta-glucoside biosynthesis|beta-glucoside formation|beta-glucoside synthesis http://purl.obolibrary.org/obo/GO_1901806 GO:1901807 biolink:BiologicalProcess capsanthin metabolic process The chemical reactions and pathways involving capsanthin. go.json capsanthin metabolism http://purl.obolibrary.org/obo/GO_1901807 GO:1901804 biolink:BiologicalProcess beta-glucoside metabolic process The chemical reactions and pathways involving beta-glucoside. go.json beta-glucoside metabolism http://purl.obolibrary.org/obo/GO_1901804 GO:1901805 biolink:BiologicalProcess beta-glucoside catabolic process The chemical reactions and pathways resulting in the breakdown of beta-glucoside. go.json beta-glucoside breakdown|beta-glucoside catabolism|beta-glucoside degradation http://purl.obolibrary.org/obo/GO_1901805 GO:1901802 biolink:BiologicalProcess 1,5-anhydro-D-fructose catabolic process The chemical reactions and pathways resulting in the breakdown of 1,5-anhydro-D-fructose. go.json 1,5-anhydro-D-fructose breakdown|1,5-anhydro-D-fructose catabolism|1,5-anhydro-D-fructose degradation http://purl.obolibrary.org/obo/GO_1901802 GO:1901803 biolink:BiologicalProcess 1,5-anhydro-D-fructose biosynthetic process The chemical reactions and pathways resulting in the formation of 1,5-anhydro-D-fructose. go.json 1,5-anhydro-D-fructose anabolism|1,5-anhydro-D-fructose biosynthesis|1,5-anhydro-D-fructose formation|1,5-anhydro-D-fructose synthesis http://purl.obolibrary.org/obo/GO_1901803 GO:1901800 biolink:BiologicalProcess positive regulation of proteasomal protein catabolic process Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. go.json activation of proteasomal protein catabolic process|activation of proteasome-mediated protein catabolic process|activation of proteasome-mediated protein catabolism|positive regulation of proteasome-mediated protein catabolic process|positive regulation of proteasome-mediated protein catabolism|up regulation of proteasomal protein catabolic process|up regulation of proteasome-mediated protein catabolic process|up regulation of proteasome-mediated protein catabolism|up-regulation of proteasomal protein catabolic process|up-regulation of proteasome-mediated protein catabolic process|up-regulation of proteasome-mediated protein catabolism|upregulation of proteasomal protein catabolic process|upregulation of proteasome-mediated protein catabolic process|upregulation of proteasome-mediated protein catabolism http://purl.obolibrary.org/obo/GO_1901800 GO:1901801 biolink:BiologicalProcess 1,5-anhydro-D-fructose metabolic process The chemical reactions and pathways involving 1,5-anhydro-D-fructose. go.json 1,5-anhydro-D-fructose metabolism http://purl.obolibrary.org/obo/GO_1901801 GO:0060710 biolink:BiologicalProcess chorio-allantoic fusion The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois. go.json http://purl.obolibrary.org/obo/GO_0060710 GO:0060711 biolink:BiologicalProcess labyrinthine layer development The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0060711 GO:0060712 biolink:BiologicalProcess spongiotrophoblast layer development The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0060712 GO:0060713 biolink:BiologicalProcess labyrinthine layer morphogenesis The process in which the labyrinthine layer of the placenta is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060713 GO:0060714 biolink:BiologicalProcess labyrinthine layer formation The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta. go.json http://purl.obolibrary.org/obo/GO_0060714 GO:0060715 biolink:BiologicalProcess syncytiotrophoblast cell differentiation involved in labyrinthine layer development The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta. go.json http://purl.obolibrary.org/obo/GO_0060715 GO:0060716 biolink:BiologicalProcess labyrinthine layer blood vessel development The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. go.json http://purl.obolibrary.org/obo/GO_0060716 GO:0060717 biolink:BiologicalProcess chorion development The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane. go.json http://purl.obolibrary.org/obo/GO_0060717 GO:0060718 biolink:BiologicalProcess chorionic trophoblast cell differentiation The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. go.json http://purl.obolibrary.org/obo/GO_0060718 GO:0060719 biolink:BiologicalProcess chorionic trophoblast cell development The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0060719 GO:1901808 biolink:BiologicalProcess capsanthin catabolic process The chemical reactions and pathways resulting in the breakdown of capsanthin. go.json capsanthin breakdown|capsanthin catabolism|capsanthin degradation http://purl.obolibrary.org/obo/GO_1901808 GO:1901809 biolink:BiologicalProcess capsanthin biosynthetic process The chemical reactions and pathways resulting in the formation of capsanthin. go.json capsanthin anabolism|capsanthin biosynthesis|capsanthin formation|capsanthin synthesis http://purl.obolibrary.org/obo/GO_1901809 GO:1901817 biolink:BiologicalProcess beta-zeacarotene catabolic process The chemical reactions and pathways resulting in the breakdown of beta-zeacarotene. go.json beta-zeacarotene breakdown|beta-zeacarotene catabolism|beta-zeacarotene degradation http://purl.obolibrary.org/obo/GO_1901817 GO:1901818 biolink:BiologicalProcess beta-zeacarotene biosynthetic process The chemical reactions and pathways resulting in the formation of beta-zeacarotene. go.json beta-zeacarotene anabolism|beta-zeacarotene biosynthesis|beta-zeacarotene formation|beta-zeacarotene synthesis http://purl.obolibrary.org/obo/GO_1901818 GO:1901815 biolink:BiologicalProcess astaxanthin biosynthetic process The chemical reactions and pathways resulting in the formation of astaxanthin. go.json astaxanthin anabolism|astaxanthin biosynthesis|astaxanthin formation|astaxanthin synthesis http://purl.obolibrary.org/obo/GO_1901815 GO:1901816 biolink:BiologicalProcess beta-zeacarotene metabolic process The chemical reactions and pathways involving beta-zeacarotene. go.json beta-zeacarotene metabolism http://purl.obolibrary.org/obo/GO_1901816 GO:1901813 biolink:BiologicalProcess astaxanthin metabolic process The chemical reactions and pathways involving astaxanthin. go.json astaxanthin metabolism http://purl.obolibrary.org/obo/GO_1901813 GO:1901814 biolink:BiologicalProcess astaxanthin catabolic process The chemical reactions and pathways resulting in the breakdown of astaxanthin. go.json astaxanthin breakdown|astaxanthin catabolism|astaxanthin degradation http://purl.obolibrary.org/obo/GO_1901814 GO:1901811 biolink:BiologicalProcess beta-carotene catabolic process The chemical reactions and pathways resulting in the breakdown of beta-carotene. go.json beta-carotene breakdown|beta-carotene catabolism|beta-carotene degradation http://purl.obolibrary.org/obo/GO_1901811 GO:1901812 biolink:BiologicalProcess beta-carotene biosynthetic process The chemical reactions and pathways resulting in the formation of beta-carotene. go.json beta-carotene anabolism|beta-carotene biosynthesis|beta-carotene formation|beta-carotene synthesis http://purl.obolibrary.org/obo/GO_1901812 GO:1901810 biolink:BiologicalProcess beta-carotene metabolic process The chemical reactions and pathways involving beta-carotene. go.json beta-carotene metabolism http://purl.obolibrary.org/obo/GO_1901810 GO:0060700 biolink:BiologicalProcess regulation of ribonuclease activity Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. go.json http://purl.obolibrary.org/obo/GO_0060700 gocheck_do_not_annotate GO:0060701 biolink:BiologicalProcess negative regulation of ribonuclease activity Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. go.json http://purl.obolibrary.org/obo/GO_0060701 gocheck_do_not_annotate GO:0060702 biolink:BiologicalProcess negative regulation of endoribonuclease activity Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. go.json http://purl.obolibrary.org/obo/GO_0060702 gocheck_do_not_annotate GO:0060703 biolink:MolecularActivity deoxyribonuclease inhibitor activity Binds to and stops, prevents or reduces the activity of deoxyribonuclease. go.json DNase inhibitor activity http://purl.obolibrary.org/obo/GO_0060703 GO:0060704 biolink:BiologicalProcess acinar cell differentiation involved in salivary gland development The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland. go.json http://purl.obolibrary.org/obo/GO_0060704 GO:0060705 biolink:BiologicalProcess neuron differentiation involved in salivary gland development The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland. go.json http://purl.obolibrary.org/obo/GO_0060705 GO:0060706 biolink:BiologicalProcess cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. go.json http://purl.obolibrary.org/obo/GO_0060706 GO:0060707 biolink:BiologicalProcess trophoblast giant cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. go.json http://purl.obolibrary.org/obo/GO_0060707 GO:0060708 biolink:BiologicalProcess spongiotrophoblast differentiation The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell. go.json spongiotrophoblast cell differentiation http://purl.obolibrary.org/obo/GO_0060708 GO:1901819 biolink:BiologicalProcess alpha-zeacarotene metabolic process The chemical reactions and pathways involving alpha-zeacarotene. go.json alpha-zeacarotene metabolism http://purl.obolibrary.org/obo/GO_1901819 GO:0060709 biolink:BiologicalProcess glycogen cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer. go.json http://purl.obolibrary.org/obo/GO_0060709 GO:1901828 biolink:BiologicalProcess zeaxanthin bis(beta-D-glucoside) metabolic process The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside). go.json zeaxanthin bis(beta-D-glucoside) metabolism|zeaxanthin diglucoside metabolism http://purl.obolibrary.org/obo/GO_1901828 GO:1901829 biolink:BiologicalProcess zeaxanthin bis(beta-D-glucoside) catabolic process The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside). go.json zeaxanthin bis(beta-D-glucoside) breakdown|zeaxanthin bis(beta-D-glucoside) catabolism|zeaxanthin bis(beta-D-glucoside) degradation|zeaxanthin diglucoside breakdown|zeaxanthin diglucoside catabolism|zeaxanthin diglucoside degradation http://purl.obolibrary.org/obo/GO_1901829 GO:1901826 biolink:BiologicalProcess zeaxanthin catabolic process The chemical reactions and pathways resulting in the breakdown of zeaxanthin. go.json zeaxanthin breakdown|zeaxanthin catabolism|zeaxanthin degradation http://purl.obolibrary.org/obo/GO_1901826 GO:1901827 biolink:BiologicalProcess zeaxanthin biosynthetic process The chemical reactions and pathways resulting in the formation of zeaxanthin. go.json zeaxanthin anabolism|zeaxanthin biosynthesis|zeaxanthin formation|zeaxanthin synthesis http://purl.obolibrary.org/obo/GO_1901827 GO:1901824 biolink:BiologicalProcess delta-carotene biosynthetic process The chemical reactions and pathways resulting in the formation of delta-carotene. go.json delta-carotene anabolism|delta-carotene biosynthesis|delta-carotene formation|delta-carotene synthesis http://purl.obolibrary.org/obo/GO_1901824 GO:1901825 biolink:BiologicalProcess zeaxanthin metabolic process The chemical reactions and pathways involving zeaxanthin. go.json zeaxanthin metabolism http://purl.obolibrary.org/obo/GO_1901825 GO:1901822 biolink:BiologicalProcess delta-carotene metabolic process The chemical reactions and pathways involving delta-carotene. go.json delta-carotene metabolism http://purl.obolibrary.org/obo/GO_1901822 GO:1901823 biolink:BiologicalProcess delta-carotene catabolic process The chemical reactions and pathways resulting in the breakdown of delta-carotene. go.json delta-carotene breakdown|delta-carotene catabolism|delta-carotene degradation http://purl.obolibrary.org/obo/GO_1901823 GO:1901820 biolink:BiologicalProcess alpha-zeacarotene catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-zeacarotene. go.json alpha-zeacarotene breakdown|alpha-zeacarotene catabolism|alpha-zeacarotene degradation http://purl.obolibrary.org/obo/GO_1901820 GO:1901821 biolink:BiologicalProcess alpha-zeacarotene biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-zeacarotene. go.json alpha-zeacarotene anabolism|alpha-zeacarotene biosynthesis|alpha-zeacarotene formation|alpha-zeacarotene synthesis http://purl.obolibrary.org/obo/GO_1901821 GO:0060730 biolink:BiologicalProcess regulation of intestinal epithelial structure maintenance Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. go.json http://purl.obolibrary.org/obo/GO_0060730 GO:0060731 biolink:BiologicalProcess positive regulation of intestinal epithelial structure maintenance Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. go.json http://purl.obolibrary.org/obo/GO_0060731 GO:0060732 biolink:BiologicalProcess positive regulation of inositol phosphate biosynthetic process Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. go.json http://purl.obolibrary.org/obo/GO_0060732 GO:0060733 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060733 GO:0060734 biolink:BiologicalProcess regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress. go.json regulation of ER stress-induced eIF2 alpha phosphorylation|regulation of eIF2 alpha phosphorylation by ER stress|regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_0060734 GO:0060735 biolink:BiologicalProcess regulation of eIF2 alpha phosphorylation by dsRNA Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA. go.json regulation of eIF2 alpha phosphorylation by PKR|regulation of eIF2 alpha phosphorylation by double-stranded RNA http://purl.obolibrary.org/obo/GO_0060735 GO:0060736 biolink:BiologicalProcess prostate gland growth The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0060736 GO:0060737 biolink:BiologicalProcess prostate gland morphogenetic growth The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form. go.json prostate gland growth involved in morphogenesis http://purl.obolibrary.org/obo/GO_0060737 GO:0060738 biolink:BiologicalProcess epithelial-mesenchymal signaling involved in prostate gland development Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time. go.json epithelial-mesenchymal signalling involved in prostate gland development http://purl.obolibrary.org/obo/GO_0060738 GO:0060739 biolink:BiologicalProcess mesenchymal-epithelial cell signaling involved in prostate gland development Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time. go.json mesenchymal-epithelial cell signalling involved in prostate gland development http://purl.obolibrary.org/obo/GO_0060739 GO:1901839 biolink:BiologicalProcess regulation of RNA polymerase I regulatory region sequence-specific DNA binding Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding. go.json http://purl.obolibrary.org/obo/GO_1901839 gocheck_do_not_annotate GO:1901837 biolink:BiologicalProcess negative regulation of transcription of nucleolar large rRNA by RNA polymerase I Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I. go.json down regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|down regulation of transcription of nuclear rRNA large Pol I transcript|down-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|down-regulation of transcription of nuclear rRNA large Pol I transcript|downregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|downregulation of transcription of nuclear rRNA large Pol I transcript|inhibition of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|inhibition of transcription of nuclear rRNA large Pol I transcript|negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|negative regulation of transcription of nuclear rRNA large Pol I transcript http://purl.obolibrary.org/obo/GO_1901837 GO:1901838 biolink:BiologicalProcess positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. go.json activation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|activation of transcription of nuclear rRNA large Pol I transcript|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|positive regulation of transcription of nuclear rRNA large Pol I transcript|up regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|up regulation of transcription of nuclear rRNA large Pol I transcript|up-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|up-regulation of transcription of nuclear rRNA large Pol I transcript|upregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|upregulation of transcription of nuclear rRNA large Pol I transcript http://purl.obolibrary.org/obo/GO_1901838 GO:1901835 biolink:BiologicalProcess positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA. go.json activation of deadenylation-independent decapping of nuclear mRNA|activation of deadenylation-independent decapping of nuclear-transcribed mRNA|activation of deadenylylation-independent decapping|positive regulation of deadenylation-independent decapping of nuclear mRNA|positive regulation of deadenylylation-independent decapping|up regulation of deadenylation-independent decapping of nuclear mRNA|up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|up regulation of deadenylylation-independent decapping|up-regulation of deadenylation-independent decapping of nuclear mRNA|up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|up-regulation of deadenylylation-independent decapping|upregulation of deadenylation-independent decapping of nuclear mRNA|upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA|upregulation of deadenylylation-independent decapping http://purl.obolibrary.org/obo/GO_1901835 GO:1901836 biolink:BiologicalProcess regulation of transcription of nucleolar large rRNA by RNA polymerase I Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. go.json regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of transcription of nuclear rRNA large Pol I transcript http://purl.obolibrary.org/obo/GO_1901836 GO:1901833 biolink:BiologicalProcess all-trans-neoxanthin biosynthetic process The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin. go.json all-trans-neoxanthin anabolism|all-trans-neoxanthin biosynthesis|all-trans-neoxanthin formation|all-trans-neoxanthin synthesis|neoxanthin anabolism|neoxanthin biosynthesis|neoxanthin biosynthetic process|neoxanthin formation|neoxanthin synthesis http://purl.obolibrary.org/obo/GO_1901833 GO:1901834 biolink:BiologicalProcess regulation of deadenylation-independent decapping of nuclear-transcribed mRNA Any process that modulates the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA. go.json regulation of deadenylation-independent decapping of nuclear mRNA|regulation of deadenylylation-independent decapping http://purl.obolibrary.org/obo/GO_1901834 GO:1901831 biolink:BiologicalProcess all-trans-neoxanthin metabolic process The chemical reactions and pathways involving all-trans-neoxanthin. go.json all-trans-neoxanthin metabolism|neoxanthin metabolic process|neoxanthin metabolism http://purl.obolibrary.org/obo/GO_1901831 GO:0045105 biolink:BiologicalProcess intermediate filament polymerization or depolymerization Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament. go.json http://purl.obolibrary.org/obo/GO_0045105 GO:1901832 biolink:BiologicalProcess all-trans-neoxanthin catabolic process The chemical reactions and pathways resulting in the breakdown of all-trans-neoxanthin. go.json all-trans-neoxanthin breakdown|all-trans-neoxanthin catabolism|all-trans-neoxanthin degradation|neoxanthin breakdown|neoxanthin catabolic process|neoxanthin catabolism|neoxanthin degradation http://purl.obolibrary.org/obo/GO_1901832 GO:0045106 biolink:BiologicalProcess intermediate filament depolymerization Disassembly of intermediate filaments by the removal of component monomers from a filament. go.json http://purl.obolibrary.org/obo/GO_0045106 GO:0045103 biolink:BiologicalProcess intermediate filament-based process Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. go.json http://purl.obolibrary.org/obo/GO_0045103 GO:0045104 biolink:BiologicalProcess intermediate filament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins. go.json intermediate filament cytoskeleton organisation|intermediate filament cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0045104 GO:1901830 biolink:BiologicalProcess zeaxanthin bis(beta-D-glucoside) biosynthetic process The chemical reactions and pathways resulting in the formation of zeaxanthin bis(beta-D-glucoside). go.json zeaxanthin bis(beta-D-glucoside) anabolism|zeaxanthin bis(beta-D-glucoside) biosynthesis|zeaxanthin bis(beta-D-glucoside) formation|zeaxanthin bis(beta-D-glucoside) synthesis|zeaxanthin diglucoside anabolism|zeaxanthin diglucoside biosynthesis|zeaxanthin diglucoside formation|zeaxanthin diglucoside synthesis http://purl.obolibrary.org/obo/GO_1901830 GO:0045101 biolink:CellularComponent obsolete glial fibrillary acidic protein OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes. go.json GFAP|glial fibrillary acidic protein True http://purl.obolibrary.org/obo/GO_0045101 GO:0045102 biolink:CellularComponent obsolete peripherin OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system. go.json peripherin True http://purl.obolibrary.org/obo/GO_0045102 GO:0045100 biolink:CellularComponent obsolete desmin OBSOLETE. A type of intermediate filament. go.json desmin True http://purl.obolibrary.org/obo/GO_0045100 GO:0060720 biolink:BiologicalProcess spongiotrophoblast cell proliferation The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer. go.json http://purl.obolibrary.org/obo/GO_0060720 GO:0045109 biolink:BiologicalProcess intermediate filament organization Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. go.json intermediate filament organisation http://purl.obolibrary.org/obo/GO_0045109 GO:0060721 biolink:BiologicalProcess regulation of spongiotrophoblast cell proliferation Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0060721 GO:0045107 biolink:BiologicalProcess intermediate filament polymerization Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain. go.json http://purl.obolibrary.org/obo/GO_0045107 GO:0060722 biolink:BiologicalProcess cell proliferation involved in embryonic placenta development The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta. go.json http://purl.obolibrary.org/obo/GO_0060722 GO:0045108 biolink:BiologicalProcess regulation of intermediate filament polymerization or depolymerization Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases. go.json http://purl.obolibrary.org/obo/GO_0045108 GO:0060723 biolink:BiologicalProcess regulation of cell proliferation involved in embryonic placenta development Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development. go.json http://purl.obolibrary.org/obo/GO_0060723 GO:0060724 biolink:MolecularActivity obsolete coreceptor activity involved in epidermal growth factor receptor signaling pathway OBSOLETE. Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway. go.json coreceptor activity involved in epidermal growth factor receptor signalling pathway True http://purl.obolibrary.org/obo/GO_0060724 GO:0060725 biolink:BiologicalProcess regulation of coreceptor activity Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0060725 gocheck_do_not_annotate GO:0060726 biolink:BiologicalProcess obsolete regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway OBSOLETE. Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. go.json regulation of Neu/ErbB-2 receptor activity|regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway True http://purl.obolibrary.org/obo/GO_0060726 GO:0060727 biolink:BiologicalProcess obsolete positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway OBSOLETE. Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. go.json positive regulation of Neu/ErbB-2 receptor activity|positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway True http://purl.obolibrary.org/obo/GO_0060727 GO:0060728 biolink:BiologicalProcess obsolete negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway OBSOLETE. Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. go.json negative regulation of Neu/ErbB-2 receptor activity|negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway True http://purl.obolibrary.org/obo/GO_0060728 GO:0060729 biolink:BiologicalProcess intestinal epithelial structure maintenance A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. go.json epithelial structure maintenance of intestine|maintenance of intestinal epithelium http://purl.obolibrary.org/obo/GO_0060729 GO:0035782 biolink:BiologicalProcess mature natural killer cell chemotaxis The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules. go.json activated natural killer cell chemotaxis http://purl.obolibrary.org/obo/GO_0035782 GO:0035783 biolink:BiologicalProcess CD4-positive, alpha-beta T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation. go.json CD4-positive, alpha beta T cell costimulation http://purl.obolibrary.org/obo/GO_0035783 GO:0035784 biolink:BiologicalProcess obsolete obsolete nickel cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell. go.json nickel homeostasis True http://purl.obolibrary.org/obo/GO_0035784 GO:0035785 biolink:BiologicalProcess intracellular nickel ion homeostasis A homeostatic process involved in the maintenance of a steady state level of nickel ions within a cell. go.json cellular nickel homeostasis|cellular nickel ion homeostasis http://purl.obolibrary.org/obo/GO_0035785 GO:0035786 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035786 GO:0035787 biolink:BiologicalProcess cell migration involved in kidney development The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ. go.json http://purl.obolibrary.org/obo/GO_0035787 GO:0035788 biolink:BiologicalProcess cell migration involved in metanephros development The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ. go.json cell migration involved in metanephric kidney development http://purl.obolibrary.org/obo/GO_0035788 GO:0035789 biolink:BiologicalProcess metanephric mesenchymal cell migration The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros. go.json metanephric mesenchyme chemotaxis http://purl.obolibrary.org/obo/GO_0035789 GO:0035780 biolink:BiologicalProcess CD80 biosynthetic process The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival. go.json CD80 anabolism|CD80 biosynthesis|CD80 formation|CD80 synthesis http://purl.obolibrary.org/obo/GO_0035780 GO:0035781 biolink:BiologicalProcess CD86 biosynthetic process The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival. go.json CD86 anabolism|CD86 biosynthesis|CD86 formation|CD86 synthesis http://purl.obolibrary.org/obo/GO_0035781 GO:0035779 biolink:BiologicalProcess angioblast cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). go.json angioblastic mesenchymal cell differentiation http://purl.obolibrary.org/obo/GO_0035779 GO:0035771 biolink:BiologicalProcess interleukin-4-mediated signaling pathway The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-4-mediated signaling pathway|interleukin-4-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0035771 GO:0035772 biolink:BiologicalProcess interleukin-13-mediated signaling pathway The series of molecular signals initiated by interleukin-13 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-13-mediated signaling pathway|interleukin-13-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0035772 GO:0035773 biolink:BiologicalProcess insulin secretion involved in cellular response to glucose stimulus The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. go.json insulin secretion involved in cellular response to glucose http://purl.obolibrary.org/obo/GO_0035773 GO:0035774 biolink:BiologicalProcess positive regulation of insulin secretion involved in cellular response to glucose stimulus Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. go.json positive regulation of insulin secretion in response to glucose http://purl.obolibrary.org/obo/GO_0035774 GO:0035775 biolink:BiologicalProcess pronephric glomerulus morphogenesis The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment. go.json http://purl.obolibrary.org/obo/GO_0035775 GO:0035776 biolink:BiologicalProcess pronephric proximal tubule development The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. go.json http://purl.obolibrary.org/obo/GO_0035776 GO:0035777 biolink:BiologicalProcess pronephric distal tubule development The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. go.json http://purl.obolibrary.org/obo/GO_0035777 GO:0035778 biolink:BiologicalProcess pronephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0035778 GO:0035770 biolink:CellularComponent ribonucleoprotein granule A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. go.json RNA granule|RNP granule|mRNP granule http://purl.obolibrary.org/obo/GO_0035770 GO:0035768 biolink:BiologicalProcess endothelial cell chemotaxis to fibroblast growth factor The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF). go.json http://purl.obolibrary.org/obo/GO_0035768 GO:0035769 biolink:BiologicalProcess B cell chemotaxis across high endothelial venule The movement of a B cell to cross a high endothelial venule in response to an external stimulus. go.json B-cell chemotaxis across high endothelial venule http://purl.obolibrary.org/obo/GO_0035769 GO:0035760 biolink:BiologicalProcess cytoplasmic polyadenylation-dependent rRNA catabolic process The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate. go.json cytoplasmic poly(A)-dependent rRNA catabolic process http://purl.obolibrary.org/obo/GO_0035760 GO:0035761 biolink:BiologicalProcess dorsal motor nucleus of vagus nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0035761 GO:0035762 biolink:BiologicalProcess dorsal motor nucleus of vagus nerve morphogenesis The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form. go.json http://purl.obolibrary.org/obo/GO_0035762 GO:0035763 biolink:BiologicalProcess dorsal motor nucleus of vagus nerve structural organization The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. go.json dorsal motor nucleus of vagus nerve structural organisation http://purl.obolibrary.org/obo/GO_0035763 GO:0035764 biolink:BiologicalProcess dorsal motor nucleus of vagus nerve formation The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0035764 GO:0035765 biolink:BiologicalProcess motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve. go.json http://purl.obolibrary.org/obo/GO_0035765 GO:0035766 biolink:BiologicalProcess cell chemotaxis to fibroblast growth factor The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF). go.json http://purl.obolibrary.org/obo/GO_0035766 GO:0035767 biolink:BiologicalProcess endothelial cell chemotaxis The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_0035767 GO:0035757 biolink:MolecularActivity chemokine (C-C motif) ligand 19 binding Binding to chemokine (C-C motif) ligand 19. go.json CCL19 binding http://purl.obolibrary.org/obo/GO_0035757 GO:0035758 biolink:MolecularActivity chemokine (C-C motif) ligand 21 binding Binding to chemokine (C-C motif) ligand 21. go.json CCL21 binding http://purl.obolibrary.org/obo/GO_0035758 GO:0035759 biolink:BiologicalProcess mesangial cell-matrix adhesion The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney. go.json http://purl.obolibrary.org/obo/GO_0035759 GO:0035750 biolink:BiologicalProcess protein localization to myelin sheath abaxonal region Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon. go.json protein localisation to myelin sheath abaxonal region http://purl.obolibrary.org/obo/GO_0035750 GO:0035751 biolink:BiologicalProcess regulation of lysosomal lumen pH Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. go.json http://purl.obolibrary.org/obo/GO_0035751 GO:0035752 biolink:BiologicalProcess lysosomal lumen pH elevation Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. go.json lysosome pH elevation http://purl.obolibrary.org/obo/GO_0035752 GO:0035753 biolink:BiologicalProcess maintenance of DNA trinucleotide repeats Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs. go.json http://purl.obolibrary.org/obo/GO_0035753 GO:0035754 biolink:BiologicalProcess B cell chemotaxis The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_0035754 GO:0035755 biolink:MolecularActivity cardiolipin hydrolase activity Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA). Reactome:R-HSA-8954398 go.json http://purl.obolibrary.org/obo/GO_0035755 GO:0035756 biolink:BiologicalProcess transepithelial migration of symbiont in host The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json migration in host through an epithelial cell layer|migration of symbiont within host by transepithelial trafficking|transmigration of symbiont in host http://purl.obolibrary.org/obo/GO_0035756 GO:0035746 biolink:BiologicalProcess granzyme A production The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0035746 gocheck_do_not_annotate GO:0035747 biolink:BiologicalProcess natural killer cell chemotaxis The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_0035747 GO:0035748 biolink:CellularComponent myelin sheath abaxonal region The region of the myelin sheath furthest from the axon. go.json http://purl.obolibrary.org/obo/GO_0035748 GO:0035749 biolink:CellularComponent myelin sheath adaxonal region The region of the myelin sheath nearest to the axon. go.json http://purl.obolibrary.org/obo/GO_0035749 GO:0035740 biolink:BiologicalProcess CD8-positive, alpha-beta T cell proliferation The expansion of a CD8-positive, alpha-beta T cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0035740 GO:0035741 biolink:BiologicalProcess activated CD4-positive, alpha-beta T cell proliferation The expansion of an activated CD4-positive, alpha-beta T cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0035741 GO:0035742 biolink:BiologicalProcess activated CD8-positive, alpha-beta T cell proliferation The expansion of an activated CD8-positive, alpha-beta T cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0035742 GO:0035743 biolink:BiologicalProcess CD4-positive, alpha-beta T cell cytokine production Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell. go.json http://purl.obolibrary.org/obo/GO_0035743 gocheck_do_not_annotate GO:0035744 biolink:BiologicalProcess T-helper 1 cell cytokine production Any process that contributes to cytokine production by a T-helper 1 cell. go.json Th1 cell cytokine production http://purl.obolibrary.org/obo/GO_0035744 gocheck_do_not_annotate GO:0035745 biolink:BiologicalProcess T-helper 2 cell cytokine production Any process that contributes to cytokine production by a T-helper 2 cell. go.json Th2 cell cytokine production http://purl.obolibrary.org/obo/GO_0035745 gocheck_do_not_annotate GO:0035735 biolink:BiologicalProcess intraciliary transport involved in cilium assembly The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. Reactome:R-HSA-5620924.2 go.json intraciliary transport involved in cilium morphogenesis|intraflagellar transport|intraflagellar transport involved in cilium morphogenesis http://purl.obolibrary.org/obo/GO_0035735 GO:0035736 biolink:BiologicalProcess cell proliferation involved in compound eye morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0035736 GO:0035737 biolink:BiologicalProcess obsolete injection of substance in to other organism OBSOLETE. The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes. go.json True http://purl.obolibrary.org/obo/GO_0035737 GO:0035738 biolink:BiologicalProcess envenomation resulting in modulation of process in another organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. go.json envenomation resulting in modification of morphology or physiology of other organism|envenomation resulting in modulation of process in other organism http://purl.obolibrary.org/obo/GO_0035738 GO:0035739 biolink:BiologicalProcess CD4-positive, alpha-beta T cell proliferation The expansion of a CD4-positive, alpha-beta T cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0035739 GO:0035730 biolink:MolecularActivity S-nitrosoglutathione binding Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems. go.json GSNO binding http://purl.obolibrary.org/obo/GO_0035730 GO:0035731 biolink:MolecularActivity dinitrosyl-iron complex binding Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO. go.json DNDGIC binding|DNIC binding|dinitrosyl-diglutathionyl-iron complex binding http://purl.obolibrary.org/obo/GO_0035731 GO:0035732 biolink:BiologicalProcess nitric oxide storage The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins. go.json NO storage http://purl.obolibrary.org/obo/GO_0035732 GO:0035733 biolink:BiologicalProcess hepatic stellate cell activation A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0035733 GO:0035734 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035734 GO:0035724 biolink:BiologicalProcess CD24 biosynthetic process The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation. go.json CD24 anabolism|CD24 biosynthesis|CD24 formation|CD24 synthesis http://purl.obolibrary.org/obo/GO_0035724 GO:0035725 biolink:BiologicalProcess sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json sodium ion membrane transport http://purl.obolibrary.org/obo/GO_0035725 GO:0035726 biolink:BiologicalProcess common myeloid progenitor cell proliferation The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage. go.json http://purl.obolibrary.org/obo/GO_0035726 GO:0035727 biolink:MolecularActivity lysophosphatidic acid binding Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors. go.json LPA binding http://purl.obolibrary.org/obo/GO_0035727 GO:0035728 biolink:BiologicalProcess response to hepatocyte growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. go.json response to HGF stimulus|response to hepatocyte growth factor stimulus http://purl.obolibrary.org/obo/GO_0035728 GO:0035729 biolink:BiologicalProcess cellular response to hepatocyte growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. go.json cellular response to HGF stimulus http://purl.obolibrary.org/obo/GO_0035729 GO:0035720 biolink:BiologicalProcess intraciliary anterograde transport The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins. go.json intraflagellar anterograde transport http://purl.obolibrary.org/obo/GO_0035720 GO:0035721 biolink:BiologicalProcess intraciliary retrograde transport The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins. go.json intraflagellar retrograde transport http://purl.obolibrary.org/obo/GO_0035721 GO:0035722 biolink:BiologicalProcess interleukin-12-mediated signaling pathway The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-12-mediated signaling pathway|interleukin-12-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0035722 GO:0035723 biolink:BiologicalProcess interleukin-15-mediated signaling pathway The series of molecular signals initiated by interleukin-15 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-15-mediated signaling pathway|interleukin-15-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0035723 GO:0035713 biolink:BiologicalProcess response to nitrogen dioxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. go.json response to NO2 http://purl.obolibrary.org/obo/GO_0035713 GO:0035714 biolink:BiologicalProcess cellular response to nitrogen dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. go.json cellular response to NO2 http://purl.obolibrary.org/obo/GO_0035714 GO:0035715 biolink:MolecularActivity chemokine (C-C motif) ligand 2 binding Binding to chemokine (C-C motif) ligand 2. go.json CCL2 binding http://purl.obolibrary.org/obo/GO_0035715 GO:0035716 biolink:MolecularActivity chemokine (C-C motif) ligand 12 binding Binding to chemokine (C-C motif) ligand 12. go.json CCL12 binding http://purl.obolibrary.org/obo/GO_0035716 GO:0035717 biolink:MolecularActivity chemokine (C-C motif) ligand 7 binding Binding to chemokine (C-C motif) ligand 7. go.json CCL7 binding http://purl.obolibrary.org/obo/GO_0035717 GO:0035718 biolink:MolecularActivity macrophage migration inhibitory factor binding Binding to the cytokine, macrophage migration inhibitory factor. go.json MIF binding http://purl.obolibrary.org/obo/GO_0035718 GO:0035719 biolink:BiologicalProcess tRNA import into nucleus The directed movement of tRNA from the cytoplasm to the nucleus. go.json retrograde tRNA transport into nucleus|tRNA nuclear import http://purl.obolibrary.org/obo/GO_0035719 GO:0035710 biolink:BiologicalProcess CD4-positive, alpha-beta T cell activation The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json http://purl.obolibrary.org/obo/GO_0035710 GO:0035711 biolink:BiologicalProcess T-helper 1 cell activation The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json Th1 cell activation http://purl.obolibrary.org/obo/GO_0035711 GO:0035712 biolink:BiologicalProcess T-helper 2 cell activation The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json Th2 cell activation http://purl.obolibrary.org/obo/GO_0035712 GO:0070031 biolink:CellularComponent alphav-beta5 integrin-osteopontin complex A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin. go.json ITGAV-ITGB5-SPP1 complex http://purl.obolibrary.org/obo/GO_0070031 GO:0045075 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045075 GO:0070032 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof). go.json SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)|Vamp2-Snap25-Stx1a-Cplx1 complex http://purl.obolibrary.org/obo/GO_0070032 GO:0045076 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045076 GO:0045073 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045073 GO:0070030 biolink:CellularComponent alphav-beta1 integrin-osteopontin complex A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin. go.json ITGAV-ITGB1-SPP1 complex http://purl.obolibrary.org/obo/GO_0070030 GO:0045074 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045074 GO:0045071 biolink:BiologicalProcess negative regulation of viral genome replication Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. go.json down regulation of viral genome replication|down-regulation of viral genome replication|downregulation of viral genome replication|inhibition of viral genome replication http://purl.obolibrary.org/obo/GO_0045071 GO:0045072 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045072 GO:0045070 biolink:BiologicalProcess positive regulation of viral genome replication Any process that activates or increases the frequency, rate or extent of viral genome replication. go.json activation of viral genome replication|stimulation of viral genome replication|up regulation of viral genome replication|up-regulation of viral genome replication|upregulation of viral genome replication http://purl.obolibrary.org/obo/GO_0045070 GO:0045079 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045079 GO:0045077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045077 GO:0045078 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045078 GO:0070039 biolink:MolecularActivity rRNA (guanosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine. Reactome:R-HSA-6793096|Reactome:R-HSA-6793122 go.json http://purl.obolibrary.org/obo/GO_0070039 GO:0070037 biolink:MolecularActivity rRNA (pseudouridine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule. Reactome:R-HSA-6790906 go.json http://purl.obolibrary.org/obo/GO_0070037 GO:0070038 biolink:MolecularActivity rRNA (pseudouridine-N3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine. go.json http://purl.obolibrary.org/obo/GO_0070038 GO:0070035 biolink:MolecularActivity obsolete purine NTP-dependent helicase activity OBSOLETE. Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. go.json True http://purl.obolibrary.org/obo/GO_0070035 GO:0070036 biolink:MolecularActivity obsolete GTP-dependent helicase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix. go.json True http://purl.obolibrary.org/obo/GO_0070036 GO:0070033 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof). go.json SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)|Vamp2-Snap25-Stx1a-Cplx2 complex http://purl.obolibrary.org/obo/GO_0070033 GO:0070034 biolink:MolecularActivity telomerase RNA binding Binding to the telomerase RNA template. go.json TERC binding http://purl.obolibrary.org/obo/GO_0070034 GO:0070020 biolink:CellularComponent obsolete transforming growth factor beta1-type II receptor complex OBSOLETE. A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer. go.json TGF-beta receptor II-TGF-beta1 complex|TGF-beta1-type II receptor complex True http://purl.obolibrary.org/obo/GO_0070020 GO:0045086 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045086 GO:0045087 biolink:BiologicalProcess innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Wikipedia:Innate_immune_system go.json innate immunity|nonspecific immune response http://purl.obolibrary.org/obo/GO_0045087 GO:0070021 biolink:CellularComponent transforming growth factor beta ligand-receptor complex A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand. go.json TGF-beta 1:type II receptor:type I receptor complex|TGF-beta ligand-receptor complex|TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex|TGF-beta1 ligand-receptor complex|TGF-beta1-beta2 ligand-receptor complex|TGF-beta1-type II receptor-type I receptor complex|TGF-beta2 ligand-receptor complex|TGFb ligand-receptor complex|TGFbeta ligand-receptor complex|TGFbeta1 ligand-receptor complex|TGFbeta1-beta2 ligand-receptor complex|TGFbeta2 ligand-receptor complex|transforming growth factor beta1-type II receptor-type I receptor complex http://purl.obolibrary.org/obo/GO_0070021 GO:0045084 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045084 GO:0045085 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045085 GO:0045082 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045082 GO:0045083 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045083 GO:0045080 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045080 GO:0045081 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045081 GO:0045088 biolink:BiologicalProcess regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. go.json http://purl.obolibrary.org/obo/GO_0045088 GO:0045089 biolink:BiologicalProcess positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. go.json stimulation of innate immune response|up regulation of innate immune response|up-regulation of innate immune response|upregulation of innate immune response http://purl.obolibrary.org/obo/GO_0045089 GO:0070028 biolink:BiologicalProcess obsolete regulation of transcription by carbon monoxide OBSOLETE. Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription. go.json regulation of transcription by CO True http://purl.obolibrary.org/obo/GO_0070028 GO:0070029 biolink:CellularComponent alphav-beta3 integrin-osteopontin complex A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin. go.json ITGAV-ITGB3-SPP1 complex http://purl.obolibrary.org/obo/GO_0070029 GO:0045090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045090 GO:0070026 biolink:MolecularActivity nitric oxide binding Binding to nitric oxide (NO). go.json NO binding|nitrogen monoxide binding|nitrosyl binding http://purl.obolibrary.org/obo/GO_0070026 GO:0070027 biolink:MolecularActivity carbon monoxide sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO). go.json carbon monoxide sensing activity http://purl.obolibrary.org/obo/GO_0070027 GO:0070024 biolink:CellularComponent CD19-Vav-PIK3R1 complex A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K). go.json CD19-Vav-PI 3-kinase (p85 subunit) complex http://purl.obolibrary.org/obo/GO_0070024 GO:0070025 biolink:MolecularActivity carbon monoxide binding Binding to carbon monoxide (CO). go.json CO binding http://purl.obolibrary.org/obo/GO_0070025 GO:0070022 biolink:CellularComponent obsolete transforming growth factor beta receptor complex OBSOLETE. A homodimeric receptor complex that consists of two TGF-beta receptor monomers. go.json TGF-beta receptor complex|transforming growth factor beta receptor complex True http://purl.obolibrary.org/obo/GO_0070022 GO:0070023 biolink:CellularComponent interleukin-12-interleukin-12 receptor complex A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer. go.json IL12-IL12 receptor complex|IL12B-IL12RB1-IL12RB2 complex http://purl.obolibrary.org/obo/GO_0070023 GO:0070053 biolink:MolecularActivity thrombospondin receptor activity Combining with thrombospondin and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0070053 GO:0045097 biolink:CellularComponent obsolete basic/neutral keratin OBSOLETE. A type of intermediate filament. go.json basic/neutral keratin|type II intermediate filament True http://purl.obolibrary.org/obo/GO_0045097 GO:0045098 biolink:CellularComponent type III intermediate filament A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments. go.json desmin|glial fibrillary acidic protein|peripherin|type III intermediate filament associated protein|vimentin http://purl.obolibrary.org/obo/GO_0045098 GO:0070054 biolink:BiologicalProcess mRNA splicing, via endonucleolytic cleavage and ligation Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. go.json cytosolic mRNA splicing http://purl.obolibrary.org/obo/GO_0070054 GO:0045095 biolink:CellularComponent keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. go.json acidic keratin|basic/neutral keratin http://purl.obolibrary.org/obo/GO_0045095 GO:0070051 biolink:MolecularActivity fibrinogen binding Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade. go.json http://purl.obolibrary.org/obo/GO_0070051 GO:0045096 biolink:CellularComponent obsolete acidic keratin OBSOLETE. A type of intermediate filament. go.json acidic keratin|type I intermediate filament True http://purl.obolibrary.org/obo/GO_0045096 GO:0070052 biolink:MolecularActivity collagen V binding Binding to a type V collagen trimer. go.json http://purl.obolibrary.org/obo/GO_0070052 GO:0045093 biolink:MolecularActivity obsolete interleukin-18 alpha subunit binding OBSOLETE. Binding to alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells. go.json IL-18Ra binding True http://purl.obolibrary.org/obo/GO_0045093 GO:0070050 biolink:BiologicalProcess neuron cellular homeostasis The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. go.json neuron maintenance http://purl.obolibrary.org/obo/GO_0070050 GO:0045094 biolink:MolecularActivity obsolete interleukin-18 beta subunit binding OBSOLETE. Binding to beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a. go.json IL-18Rb binding True http://purl.obolibrary.org/obo/GO_0045094 GO:0045091 biolink:BiologicalProcess regulation of single stranded viral RNA replication via double stranded DNA intermediate Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. go.json regulation of retroviral genome replication http://purl.obolibrary.org/obo/GO_0045091 GO:0045092 biolink:CellularComponent interleukin-18 receptor complex A protein complex that binds interleukin-18; comprises an alpha and a beta subunit. go.json IL-18 receptor complex http://purl.obolibrary.org/obo/GO_0045092 GO:0045099 biolink:CellularComponent obsolete vimentin OBSOLETE. A type of intermediate filament. go.json vimentin True http://purl.obolibrary.org/obo/GO_0045099 GO:0070059 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. go.json ER stress-induced apoptosis|apoptosis in response to ER stress|apoptosis in response to endoplasmic reticulum stress|apoptosis triggered by ER stress|endoplasmic reticulum stress-induced apoptosis|intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_0070059 GO:0070057 biolink:CellularComponent prospore membrane spindle pole body attachment site The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus. go.json forespore membrane SPB attachment site|forespore membrane spindle pole body attachment site|prospore membrane SPB attachment site http://purl.obolibrary.org/obo/GO_0070057 GO:0070058 biolink:BiologicalProcess tRNA gene clustering The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0070058 GO:0070055 biolink:BiologicalProcess obsolete mRNA endonucleolytic cleavage involved in unfolded protein response OBSOLETE. The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response. go.json ERN1-mediated XBP-1 mRNA cleavage|HAC1 mRNA cleavage|HAC1-type intron splice site recognition and cleavage|IRE1-mediated XBP-1 mRNA cleavage|XBP1 mRNA cleavage True http://purl.obolibrary.org/obo/GO_0070055 GO:0070056 biolink:CellularComponent prospore membrane leading edge The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization. go.json forespore membrane leading edge http://purl.obolibrary.org/obo/GO_0070056 GO:0070042 biolink:MolecularActivity rRNA (uridine-N3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine. go.json http://purl.obolibrary.org/obo/GO_0070042 GO:0070043 biolink:MolecularActivity rRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine. Reactome:R-HSA-6790982 go.json http://purl.obolibrary.org/obo/GO_0070043 GO:0070040 biolink:MolecularActivity rRNA (adenine(2503)-C2-)-methyltransferase activity Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine. EC:2.1.1.192|MetaCyc:RXN-11586|MetaCyc:RXN0-7007|RHEA:42916 go.json rRNA (adenine-C2-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0070040 GO:0070041 biolink:MolecularActivity rRNA (uridine-C5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine. go.json http://purl.obolibrary.org/obo/GO_0070041 GO:0070048 biolink:CellularComponent endobrevin-SNAP-25-syntaxin-1a complex A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof). go.json SNARE complex (Stx1a, Snap25, Vamp8)|Stx1a-Snap25-Vamp8 complex http://purl.obolibrary.org/obo/GO_0070048 GO:0070049 biolink:CellularComponent endobrevin-SNAP-25-syntaxin-2 complex A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof). go.json SNARE complex (Stx2, Snap25, Vamp8)|Stx2-Snap25-Vamp8 complex http://purl.obolibrary.org/obo/GO_0070049 GO:0070046 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-3 complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof). go.json SNARE complex (Stx3, Snap25, Vamp2)|Stx3-Snap25-Vamp2 complex http://purl.obolibrary.org/obo/GO_0070046 GO:0070047 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-4 complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof). go.json SNARE complex (Stx4, Snap25, Vamp2)|Stx4-Snap25-Vamp2 complex http://purl.obolibrary.org/obo/GO_0070047 GO:0070044 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-1a complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof). go.json SNARE complex (Snap25, Stx1a, Vamp2)|SNARE complex (Stx1a, SNAP25, VAMP)|Snap25-Stx1a-Vamp2 complex|Stx1a-SNAP25-VAMP complex http://purl.obolibrary.org/obo/GO_0070044 GO:0070045 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-2 complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof). go.json SNARE complex (Stx2, Snap25, Vamp2)|Stx2-Snap25-Vamp2 complex http://purl.obolibrary.org/obo/GO_0070045 GO:0070075 biolink:BiologicalProcess tear secretion The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium. go.json http://purl.obolibrary.org/obo/GO_0070075 GO:0070076 biolink:BiologicalProcess histone lysine demethylation The modification of a histone by the removal of a methyl group from a lysine residue. go.json http://purl.obolibrary.org/obo/GO_0070076 gocheck_do_not_annotate GO:0070073 biolink:BiologicalProcess clustering of voltage-gated calcium channels The process in which voltage-gated calcium channels become localized together in high densities. go.json clustering of voltage gated calcium channels|clustering of voltage-dependent calcium channels|voltage-gated calcium channel clustering http://purl.obolibrary.org/obo/GO_0070073 GO:0070074 biolink:CellularComponent mononeme A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts. go.json http://purl.obolibrary.org/obo/GO_0070074 GO:0070071 biolink:BiologicalProcess proton-transporting two-sector ATPase complex assembly The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. go.json http://purl.obolibrary.org/obo/GO_0070071 GO:0070072 biolink:BiologicalProcess vacuolar proton-transporting V-type ATPase complex assembly The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane. go.json V-ATPase assembly|V-ATPase complex assembly http://purl.obolibrary.org/obo/GO_0070072 GO:0070070 biolink:BiologicalProcess proton-transporting V-type ATPase complex assembly The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. go.json V-ATPase assembly|V-ATPase complex assembly http://purl.obolibrary.org/obo/GO_0070070 GO:0070079 biolink:BiologicalProcess histone H4-R3 demethylation The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone. go.json http://purl.obolibrary.org/obo/GO_0070079 gocheck_do_not_annotate GO:0070077 biolink:BiologicalProcess obsolete histone arginine demethylation OBSOLETE. The modification of a histone by the removal of a methyl group from an arginine residue. go.json True http://purl.obolibrary.org/obo/GO_0070077 GO:0070078 biolink:BiologicalProcess histone H3-R2 demethylation The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone. go.json http://purl.obolibrary.org/obo/GO_0070078 gocheck_do_not_annotate GO:0070064 biolink:MolecularActivity proline-rich region binding Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. go.json http://purl.obolibrary.org/obo/GO_0070064 GO:0070065 biolink:CellularComponent cellubrevin-VAMP4-syntaxin-16 complex A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof). go.json SNARE complex (Vamp3, Vamp4, Stx16)|Vamp3-Vamp4-Stx16 complex http://purl.obolibrary.org/obo/GO_0070065 GO:0070062 biolink:CellularComponent extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. go.json exosome|extracellular vesicular exosome http://purl.obolibrary.org/obo/GO_0070062 GO:0070063 biolink:MolecularActivity RNA polymerase binding Binding to an RNA polymerase molecule or complex. go.json http://purl.obolibrary.org/obo/GO_0070063 GO:0070060 biolink:BiologicalProcess 'de novo' actin filament nucleation The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament. go.json formin-mediated actin filament nucleation|unbranched actin filament nucleation http://purl.obolibrary.org/obo/GO_0070060 GO:0070061 biolink:MolecularActivity fructose binding Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. go.json http://purl.obolibrary.org/obo/GO_0070061 GO:0035694 biolink:BiologicalProcess mitochondrial protein catabolic process The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. go.json catabolism of mitochondrial protein|degradation of damaged mitochondrial protein http://purl.obolibrary.org/obo/GO_0035694 GO:0035695 biolink:BiologicalProcess mitophagy by internal vacuole formation The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes. go.json MIV-mediated mitophagy http://purl.obolibrary.org/obo/GO_0035695 GO:0035696 biolink:BiologicalProcess monocyte extravasation The migration of a monocyte from the blood vessels into the surrounding tissue. go.json http://purl.obolibrary.org/obo/GO_0035696 GO:0035697 biolink:BiologicalProcess CD8-positive, alpha-beta T cell extravasation The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue. go.json http://purl.obolibrary.org/obo/GO_0035697 GO:0035698 biolink:BiologicalProcess CD8-positive, alpha-beta cytotoxic T cell extravasation The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue. go.json http://purl.obolibrary.org/obo/GO_0035698 GO:0035699 biolink:BiologicalProcess T-helper 17 cell extravasation The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue. go.json http://purl.obolibrary.org/obo/GO_0035699 GO:0070068 biolink:CellularComponent VAMP4-syntaxin-6-syntaxin-16-Vti1a complex A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof). go.json SNARE complex (Vamp4, Stx6, Stx16, Vti1a)|Vamp4-Stx6-Stx16-Vti1a complex http://purl.obolibrary.org/obo/GO_0070068 GO:0035690 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035690 GO:0035691 biolink:BiologicalProcess macrophage migration inhibitory factor signaling pathway The series of molecular signals initiated by macrophage migration inhibitory factor binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json MIF signaling pathway|macrophage migration inhibitory factor signalling pathway http://purl.obolibrary.org/obo/GO_0035691 GO:0070069 biolink:CellularComponent cytochrome complex A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. go.json http://purl.obolibrary.org/obo/GO_0070069 GO:0035692 biolink:CellularComponent macrophage migration inhibitory factor receptor complex A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins. go.json http://purl.obolibrary.org/obo/GO_0035692 GO:0070066 biolink:CellularComponent cellubrevin-VAMP4-endobrevin-syntaxin-6 complex A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof). go.json SNARE complex (Vamp3, Vamp4, Vam8, Stx6)|Vamp3-Vamp4-Vam8-Stx6 complex http://purl.obolibrary.org/obo/GO_0070066 GO:0035693 biolink:CellularComponent NOS2-CD74 complex A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases. go.json http://purl.obolibrary.org/obo/GO_0035693 GO:0070067 biolink:CellularComponent syntaxin-6-syntaxin-16-Vti1a complex A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof). go.json http://purl.obolibrary.org/obo/GO_0070067 GO:0070097 biolink:MolecularActivity delta-catenin binding Binding to the delta subunit of the catenin complex. go.json http://purl.obolibrary.org/obo/GO_0070097 GO:0070098 biolink:BiologicalProcess chemokine-mediated signaling pathway The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json chemokine-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070098 GO:0070095 biolink:MolecularActivity fructose-6-phosphate binding Binding to fructose 6-phosphate. go.json D-fructose 6-phosphate binding|fructose 6-phosphate binding http://purl.obolibrary.org/obo/GO_0070095 GO:0070096 biolink:BiologicalProcess mitochondrial outer membrane translocase complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex. go.json TOM complex assembly|mitochondrion outer membrane translocase complex assembly http://purl.obolibrary.org/obo/GO_0070096 GO:0070093 biolink:BiologicalProcess negative regulation of glucagon secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. go.json down regulation of glucagon secretion|down-regulation of glucagon secretion|downregulation of glucagon secretion|inhibition of glucagon secretion http://purl.obolibrary.org/obo/GO_0070093 GO:0070094 biolink:BiologicalProcess positive regulation of glucagon secretion Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. go.json activation of glucagon secretion|stimulation of glucagon secretion|up regulation of glucagon secretion|up-regulation of glucagon secretion|upregulation of glucagon secretion http://purl.obolibrary.org/obo/GO_0070094 GO:0070091 biolink:BiologicalProcess glucagon secretion The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). go.json http://purl.obolibrary.org/obo/GO_0070091 GO:0070092 biolink:BiologicalProcess regulation of glucagon secretion Any process that modulates the frequency, rate or extent of the regulated release of glucagon. go.json http://purl.obolibrary.org/obo/GO_0070092 GO:0070090 biolink:CellularComponent metaphase plate The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division. go.json http://purl.obolibrary.org/obo/GO_0070090 GO:0035683 biolink:BiologicalProcess memory T cell extravasation The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. go.json memory T-cell extravasation http://purl.obolibrary.org/obo/GO_0035683 GO:0035684 biolink:BiologicalProcess helper T cell extravasation The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells. go.json T-helper cell extravasation|helper T-cell extravasation http://purl.obolibrary.org/obo/GO_0035684 GO:0035685 biolink:BiologicalProcess helper T cell diapedesis The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. go.json T-helper cell diapedesis|helper T-cell diapedesis http://purl.obolibrary.org/obo/GO_0035685 GO:0035686 biolink:CellularComponent sperm fibrous sheath A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. go.json flagellar fibrous sheath|flagellum fibrous sheath http://purl.obolibrary.org/obo/GO_0035686 GO:0035687 biolink:BiologicalProcess T-helper 1 cell extravasation The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. go.json Th1 cell extravasation http://purl.obolibrary.org/obo/GO_0035687 GO:0035688 biolink:BiologicalProcess T-helper 1 cell diapedesis The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. go.json Th1 cell diapedesis http://purl.obolibrary.org/obo/GO_0035688 GO:0035689 biolink:BiologicalProcess chemokine (C-C motif) ligand 5 signaling pathway The series of molecular signals initiated by chemokine CCL5 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CCL5-mediated signaling pathway|RANTES-mediated signaling pathway|chemokine (C-C motif) ligand 5 signalling pathway http://purl.obolibrary.org/obo/GO_0035689 GO:0035680 biolink:BiologicalProcess posterior lateral line neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. go.json http://purl.obolibrary.org/obo/GO_0035680 GO:0070099 biolink:BiologicalProcess regulation of chemokine-mediated signaling pathway Any process that modulates the rate, frequency or extent of a chemokine-mediated signaling pathway. go.json regulation of chemokine-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070099 GO:0035681 biolink:BiologicalProcess toll-like receptor 15 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 15. go.json TLR15 signaling pathway|toll-like receptor 15 signalling pathway http://purl.obolibrary.org/obo/GO_0035681 GO:0035682 biolink:BiologicalProcess toll-like receptor 21 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 21. go.json TLR21 signaling pathway|toll-like receptor 21 signalling pathway http://purl.obolibrary.org/obo/GO_0035682 GO:0070086 biolink:BiologicalProcess ubiquitin-dependent endocytosis Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded. go.json ubiquitin-mediated endocytosis http://purl.obolibrary.org/obo/GO_0070086 GO:0070087 biolink:MolecularActivity chromo shadow domain binding Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. go.json chromoshadow domain binding http://purl.obolibrary.org/obo/GO_0070087 GO:0070084 biolink:BiologicalProcess obsolete protein initiator methionine removal OBSOLETE. The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein. go.json removal of initiator methionine from protein True http://purl.obolibrary.org/obo/GO_0070084 GO:0070085 biolink:BiologicalProcess glycosylation The covalent attachment and further modification of carbohydrate residues to a substrate molecule. Wikipedia:Glycosylation go.json http://purl.obolibrary.org/obo/GO_0070085 GO:0070082 biolink:CellularComponent clathrin-sculpted monoamine transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle. go.json clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen|clathrin sculpted monoamine transport vesicle lumen http://purl.obolibrary.org/obo/GO_0070082 GO:0070083 biolink:CellularComponent clathrin-sculpted monoamine transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle. go.json clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane http://purl.obolibrary.org/obo/GO_0070083 GO:0070080 biolink:MolecularActivity titin Z domain binding Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. go.json Z repeat domain binding http://purl.obolibrary.org/obo/GO_0070080 GO:0070081 biolink:CellularComponent clathrin-sculpted monoamine transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines. go.json clathrin sculpted monoamine constitutive secretory pathway transport vesicle|clathrin sculpted monoamine transport vesicle http://purl.obolibrary.org/obo/GO_0070081 GO:0104004 biolink:BiologicalProcess cellular response to environmental stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus. go.json http://purl.obolibrary.org/obo/GO_0104004 GO:0104005 biolink:MolecularActivity obsolete hijacked molecular function OBSOLETE. A function that was not selected for in the evolution of an organism, but arises from co-option by another organism, e.g. a human protein used as a virus receptor. go.json True http://purl.obolibrary.org/obo/GO_0104005 GO:0035672 biolink:BiologicalProcess oligopeptide transmembrane transport The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. go.json oligopeptide membrane transport http://purl.obolibrary.org/obo/GO_0035672 GO:0035673 biolink:MolecularActivity oligopeptide transmembrane transporter activity Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. go.json oligopeptide transporter activity http://purl.obolibrary.org/obo/GO_0035673 GO:0035674 biolink:BiologicalProcess tricarboxylic acid transmembrane transport The process in which a tricarboxylic acid is transported across a membrane. go.json tricarboxylic acid membrane transport http://purl.obolibrary.org/obo/GO_0035674 GO:0035675 biolink:BiologicalProcess neuromast hair cell development The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0035675 GO:0035676 biolink:BiologicalProcess anterior lateral line neuromast hair cell development The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0035676 GO:0035677 biolink:BiologicalProcess posterior lateral line neuromast hair cell development The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0035677 GO:0035678 biolink:BiologicalProcess neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. go.json http://purl.obolibrary.org/obo/GO_0035678 GO:0035679 biolink:BiologicalProcess anterior lateral line neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. go.json http://purl.obolibrary.org/obo/GO_0035679 GO:0035670 biolink:BiologicalProcess plant-type ovary development The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed. go.json http://purl.obolibrary.org/obo/GO_0035670 GO:0070088 biolink:CellularComponent polyhydroxyalkanoate granule An inclusion body located in the cytoplasm of prokaryotes that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR. go.json PHA granule|PHB granule|carbonosome http://purl.obolibrary.org/obo/GO_0070088 GO:0070089 biolink:MolecularActivity chloride-activated potassium channel activity Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. go.json http://purl.obolibrary.org/obo/GO_0070089 GO:0035671 biolink:MolecularActivity enone reductase activity Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. MetaCyc:RXN-12267 go.json http://purl.obolibrary.org/obo/GO_0035671 GO:1901729 biolink:BiologicalProcess monensin A catabolic process The chemical reactions and pathways resulting in the breakdown of monensin A. go.json monensin A breakdown|monensin A catabolism|monensin A degradation|monensin breakdown|monensin catabolism|monensin degradation http://purl.obolibrary.org/obo/GO_1901729 GO:1901727 biolink:BiologicalProcess positive regulation of histone deacetylase activity Any process that activates or increases the frequency, rate or extent of histone deacetylase activity. go.json activation of histone deacetylase activity|up regulation of histone deacetylase activity|up-regulation of histone deacetylase activity|upregulation of histone deacetylase activity http://purl.obolibrary.org/obo/GO_1901727 gocheck_do_not_annotate GO:1901728 biolink:BiologicalProcess monensin A metabolic process The chemical reactions and pathways involving monensin A. go.json monensin A metabolism|monensin metabolism http://purl.obolibrary.org/obo/GO_1901728 GO:1901725 biolink:BiologicalProcess regulation of histone deacetylase activity Any process that modulates the frequency, rate or extent of histone deacetylase activity. go.json http://purl.obolibrary.org/obo/GO_1901725 gocheck_do_not_annotate GO:1901726 biolink:BiologicalProcess negative regulation of histone deacetylase activity Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity. go.json down regulation of histone deacetylase activity|down-regulation of histone deacetylase activity|downregulation of histone deacetylase activity|inhibition of histone deacetylase activity http://purl.obolibrary.org/obo/GO_1901726 gocheck_do_not_annotate GO:1901723 biolink:BiologicalProcess negative regulation of cell proliferation involved in kidney development Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development. go.json down regulation of cell proliferation involved in kidney development|down-regulation of cell proliferation involved in kidney development|downregulation of cell proliferation involved in kidney development|inhibition of cell proliferation involved in kidney development http://purl.obolibrary.org/obo/GO_1901723 GO:1901724 biolink:BiologicalProcess positive regulation of cell proliferation involved in kidney development Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development. go.json activation of cell proliferation involved in kidney development|up regulation of cell proliferation involved in kidney development|up-regulation of cell proliferation involved in kidney development|upregulation of cell proliferation involved in kidney development http://purl.obolibrary.org/obo/GO_1901724 GO:1901721 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901721 GO:1901722 biolink:BiologicalProcess regulation of cell proliferation involved in kidney development Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. go.json http://purl.obolibrary.org/obo/GO_1901722 GO:1901720 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901720 GO:0060630 biolink:BiologicalProcess obsolete regulation of M/G1 transition of mitotic cell cycle OBSOLETE. Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle. go.json regulation of M/G1 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0060630 GO:0060631 biolink:BiologicalProcess regulation of meiosis I Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. go.json http://purl.obolibrary.org/obo/GO_0060631 GO:0060632 biolink:BiologicalProcess regulation of microtubule-based movement Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_0060632 GO:0060633 biolink:BiologicalProcess negative regulation of transcription initiation by RNA polymerase II Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. go.json negative regulation of transcription initiation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0060633 GO:0060634 biolink:BiologicalProcess regulation of 4,6-pyruvylated galactose residue biosynthetic process Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain. go.json http://purl.obolibrary.org/obo/GO_0060634 GO:0060635 biolink:BiologicalProcess positive regulation of (1->3)-beta-D-glucan biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans. go.json positive regulation of 1,3-beta-D-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0060635 GO:0060636 biolink:BiologicalProcess negative regulation of (1->3)-beta-D-glucan biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans. go.json negative regulation of 1,3-beta-D-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0060636 GO:0060637 biolink:BiologicalProcess positive regulation of lactation by mesenchymal-epithelial cell signaling The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell. go.json positive regulation of lactation by mesenchymal-epithelial cell signalling http://purl.obolibrary.org/obo/GO_0060637 GO:0060638 biolink:BiologicalProcess mesenchymal-epithelial cell signaling Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. go.json mesenchymal-epithelial cell signalling http://purl.obolibrary.org/obo/GO_0060638 GO:0060639 biolink:BiologicalProcess positive regulation of salivary gland formation by mesenchymal-epithelial signaling Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell. go.json positive regulation of salivary gland formation by mesenchymal-epithelial signalling http://purl.obolibrary.org/obo/GO_0060639 GO:1901738 biolink:BiologicalProcess regulation of vitamin A metabolic process Any process that modulates the frequency, rate or extent of vitamin A metabolic process. go.json regulation of vitamin A metabolism http://purl.obolibrary.org/obo/GO_1901738 GO:1901739 biolink:BiologicalProcess regulation of myoblast fusion Any process that modulates the frequency, rate or extent of myoblast fusion. go.json http://purl.obolibrary.org/obo/GO_1901739 GO:1901736 biolink:BiologicalProcess (R)-mevalonic acid catabolic process The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid. go.json (R)-mevalonate breakdown|(R)-mevalonate catabolism|(R)-mevalonate degradation|(R)-mevalonic acid breakdown|(R)-mevalonic acid catabolism|(R)-mevalonic acid degradation http://purl.obolibrary.org/obo/GO_1901736 GO:1901737 biolink:BiologicalProcess (R)-mevalonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid. go.json (R)-mevalonate anabolism|(R)-mevalonate biosynthesis|(R)-mevalonate synthesis|(R)-mevalonic acid anabolism|(R)-mevalonic acid biosynthesis|(R)-mevalonic acid formation|(R)-mevalonic acid synthesis http://purl.obolibrary.org/obo/GO_1901737 GO:1901734 biolink:BiologicalProcess quercetin biosynthetic process The chemical reactions and pathways resulting in the formation of quercetin. go.json quercetin anabolism|quercetin biosynthesis|quercetin formation|quercetin synthesis http://purl.obolibrary.org/obo/GO_1901734 GO:1901735 biolink:BiologicalProcess (R)-mevalonic acid metabolic process The chemical reactions and pathways involving (R)-mevalonic acid. go.json (R) mevalonate metabolism|(R)-mevalonic acid metabolism http://purl.obolibrary.org/obo/GO_1901735 GO:1901732 biolink:BiologicalProcess quercetin metabolic process The chemical reactions and pathways involving quercetin. go.json quercetin metabolism http://purl.obolibrary.org/obo/GO_1901732 GO:0045006 biolink:BiologicalProcess DNA deamination The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil. go.json http://purl.obolibrary.org/obo/GO_0045006 GO:1901733 biolink:BiologicalProcess quercetin catabolic process The chemical reactions and pathways resulting in the breakdown of quercetin. go.json quercetin breakdown|quercetin catabolism|quercetin degradation http://purl.obolibrary.org/obo/GO_1901733 GO:0045007 biolink:BiologicalProcess depurination The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar. Wikipedia:Depurination go.json http://purl.obolibrary.org/obo/GO_0045007 GO:1901730 biolink:BiologicalProcess monensin A biosynthetic process The chemical reactions and pathways resulting in the formation of monensin A. go.json monensin A anabolism|monensin A biosynthesis|monensin A formation|monensin A synthesis|monensin anabolism|monensin biosynthesis|monensin formation|monensin synthesis http://purl.obolibrary.org/obo/GO_1901730 GO:0045004 biolink:BiologicalProcess DNA replication proofreading Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. go.json http://purl.obolibrary.org/obo/GO_0045004 GO:0045005 biolink:BiologicalProcess DNA-templated DNA replication maintenance of fidelity A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. go.json DNA-dependent DNA replication maintenance of fidelity|maintenance of fidelity during DNA-dependent DNA replication|maintenance of fidelity involved in DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0045005 GO:1901731 biolink:BiologicalProcess positive regulation of platelet aggregation Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. go.json activation of blood platelet aggregation|activation of platelet aggregation|activation of thrombocyte aggregation|positive regulation of blood platelet aggregation|positive regulation of thrombocyte aggregation|up regulation of blood platelet aggregation|up regulation of platelet aggregation|up regulation of thrombocyte aggregation|up-regulation of blood platelet aggregation|up-regulation of platelet aggregation|up-regulation of thrombocyte aggregation|upregulation of blood platelet aggregation|upregulation of platelet aggregation|upregulation of thrombocyte aggregation http://purl.obolibrary.org/obo/GO_1901731 GO:0045002 biolink:BiologicalProcess double-strand break repair via single-strand annealing Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. go.json http://purl.obolibrary.org/obo/GO_0045002 GO:0045003 biolink:BiologicalProcess double-strand break repair via synthesis-dependent strand annealing SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. go.json SDSA|mitotic gene conversion http://purl.obolibrary.org/obo/GO_0045003 GO:0045001 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045001 GO:0060620 biolink:BiologicalProcess regulation of cholesterol import Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0060620 GO:0060621 biolink:BiologicalProcess negative regulation of cholesterol import Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0060621 GO:0060622 biolink:BiologicalProcess regulation of ascospore wall beta-glucan biosynthetic process Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. go.json http://purl.obolibrary.org/obo/GO_0060622 GO:0060623 biolink:BiologicalProcess regulation of chromosome condensation Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. go.json http://purl.obolibrary.org/obo/GO_0060623 GO:0045008 biolink:BiologicalProcess depyrimidination The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar. go.json http://purl.obolibrary.org/obo/GO_0045008 GO:0060624 biolink:BiologicalProcess regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process Any process that modulates the rate, frequency, or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D--glucosidic bonds, found in the walls of ascospores. go.json regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process|regulation of ascospore wall 1,3-beta-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0060624 GO:0045009 biolink:CellularComponent chitosome An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum. go.json http://purl.obolibrary.org/obo/GO_0045009 GO:0060625 biolink:BiologicalProcess regulation of protein deneddylation Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein. go.json regulation of cullin deneddylation http://purl.obolibrary.org/obo/GO_0060625 GO:0060626 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060626 GO:0060627 biolink:BiologicalProcess regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0060627 GO:0060628 biolink:BiologicalProcess regulation of ER to Golgi vesicle-mediated transport Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. go.json http://purl.obolibrary.org/obo/GO_0060628 GO:0060629 biolink:BiologicalProcess regulation of homologous chromosome segregation Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. go.json http://purl.obolibrary.org/obo/GO_0060629 GO:0045010 biolink:BiologicalProcess actin nucleation The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. go.json actin filament nucleation http://purl.obolibrary.org/obo/GO_0045010 GO:1901749 biolink:BiologicalProcess leukotriene D4 catabolic process The chemical reactions and pathways resulting in the breakdown of leukotriene D4. go.json leukotriene D4 breakdown|leukotriene D4 catabolism|leukotriene D4 degradation http://purl.obolibrary.org/obo/GO_1901749 GO:1901747 biolink:BiologicalProcess prephenate(2-) biosynthetic process The chemical reactions and pathways resulting in the formation of prephenate(2-). go.json prephenate anabolism|prephenate biosynthesis|prephenate formation|prephenate synthesis|prephenate(2-) anabolism|prephenate(2-) biosynthesis|prephenate(2-) formation|prephenate(2-) synthesis http://purl.obolibrary.org/obo/GO_1901747 GO:1901748 biolink:BiologicalProcess leukotriene D4 metabolic process The chemical reactions and pathways involving leukotriene D4. go.json leukotriene D4 metabolism http://purl.obolibrary.org/obo/GO_1901748 GO:1901745 biolink:BiologicalProcess prephenate(2-) metabolic process The chemical reactions and pathways involving prephenate(2-). go.json prephenate metabolism|prephenate(2-) metabolism http://purl.obolibrary.org/obo/GO_1901745 GO:1901746 biolink:BiologicalProcess prephenate(2-) catabolic process The chemical reactions and pathways resulting in the breakdown of prephenate(2-). go.json prephenate breakdown|prephenate catabolism|prephenate degradation|prephenate(2-) breakdown|prephenate(2-) catabolism|prephenate(2-) degradation http://purl.obolibrary.org/obo/GO_1901746 GO:0045017 biolink:BiologicalProcess glycerolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. go.json glycerolipid anabolism|glycerolipid biosynthesis|glycerolipid formation|glycerolipid synthesis http://purl.obolibrary.org/obo/GO_0045017 GO:1901743 biolink:BiologicalProcess 2-deoxystreptamine catabolic process The chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine. go.json 2-deoxystreptamine breakdown|2-deoxystreptamine catabolism|2-deoxystreptamine degradation http://purl.obolibrary.org/obo/GO_1901743 GO:1901744 biolink:BiologicalProcess 2-deoxystreptamine biosynthetic process The chemical reactions and pathways resulting in the formation of 2-deoxystreptamine. go.json 2-deoxystreptamine anabolism|2-deoxystreptamine biosynthesis|2-deoxystreptamine formation|2-deoxystreptamine synthesis http://purl.obolibrary.org/obo/GO_1901744 GO:0045018 biolink:BiologicalProcess retrograde transport, vacuole to Golgi The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment. go.json retrograde transport from the vacuole http://purl.obolibrary.org/obo/GO_0045018 GO:0045015 biolink:MolecularActivity HDEL sequence binding Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. go.json HDEL receptor activity http://purl.obolibrary.org/obo/GO_0045015 GO:1901741 biolink:BiologicalProcess positive regulation of myoblast fusion Any process that activates or increases the frequency, rate or extent of myoblast fusion. go.json activation of myoblast fusion|up regulation of myoblast fusion|up-regulation of myoblast fusion|upregulation of myoblast fusion http://purl.obolibrary.org/obo/GO_1901741 GO:1901742 biolink:BiologicalProcess 2-deoxystreptamine metabolic process The chemical reactions and pathways involving 2-deoxystreptamine. go.json 2-deoxystreptamine metabolism http://purl.obolibrary.org/obo/GO_1901742 GO:0045016 biolink:BiologicalProcess mitochondrial magnesium ion transmembrane transport The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json mitochondrial magnesium ion transport http://purl.obolibrary.org/obo/GO_0045016 GO:0045013 biolink:BiologicalProcess carbon catabolite repression of transcription A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. go.json carbon catabolite repression|negative regulation of transcription by carbon catabolites http://purl.obolibrary.org/obo/GO_0045013 GO:1901740 biolink:BiologicalProcess negative regulation of myoblast fusion Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion. go.json down regulation of myoblast fusion|down-regulation of myoblast fusion|downregulation of myoblast fusion|inhibition of myoblast fusion http://purl.obolibrary.org/obo/GO_1901740 GO:0045014 biolink:BiologicalProcess carbon catabolite repression of transcription by glucose A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. go.json down regulation of transcription by glucose|down-regulation of transcription by glucose|downregulation of transcription by glucose|glucose effect|glucose repression|inhibition of transcription by glucose http://purl.obolibrary.org/obo/GO_0045014 GO:0045011 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045011 GO:0045012 biolink:MolecularActivity obsolete MHC class II receptor activity OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes. go.json MHC class II receptor activity|class II major histocompatibility complex antigen|major histocompatibility complex class II receptor True http://purl.obolibrary.org/obo/GO_0045012 GO:0060650 biolink:BiologicalProcess epithelial cell proliferation involved in mammary gland bud elongation The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud. go.json http://purl.obolibrary.org/obo/GO_0060650 GO:0060651 biolink:BiologicalProcess regulation of epithelial cell proliferation involved in mammary gland bud elongation Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud. go.json http://purl.obolibrary.org/obo/GO_0060651 GO:0060652 biolink:BiologicalProcess mammary gland cord morphogenesis The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat. go.json mammary gland sprout morphogenesis http://purl.obolibrary.org/obo/GO_0060652 GO:0060653 biolink:BiologicalProcess epithelial cell differentiation involved in mammary gland cord morphogenesis The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified. go.json epithelial cell differentiation involved in mammary gland sprout morphogenesis http://purl.obolibrary.org/obo/GO_0060653 GO:0060654 biolink:BiologicalProcess mammary gland cord elongation The process in which the mammary gland sprout grows along its axis. go.json http://purl.obolibrary.org/obo/GO_0060654 GO:0060655 biolink:BiologicalProcess branching involved in mammary gland cord morphogenesis The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct. go.json http://purl.obolibrary.org/obo/GO_0060655 GO:0060656 biolink:BiologicalProcess regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell. go.json regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling http://purl.obolibrary.org/obo/GO_0060656 GO:0045019 biolink:BiologicalProcess negative regulation of nitric oxide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. go.json down regulation of nitric oxide biosynthetic process|down-regulation of nitric oxide biosynthetic process|downregulation of nitric oxide biosynthetic process|inhibition of nitric oxide biosynthetic process|negative regulation of nitric oxide anabolism|negative regulation of nitric oxide biosynthesis|negative regulation of nitric oxide formation|negative regulation of nitric oxide synthesis http://purl.obolibrary.org/obo/GO_0045019 GO:0060657 biolink:BiologicalProcess regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell. go.json regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling http://purl.obolibrary.org/obo/GO_0060657 GO:0060658 biolink:BiologicalProcess nipple morphogenesis The process in which the nipple is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060658 GO:0060659 biolink:BiologicalProcess nipple sheath formation The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate. go.json http://purl.obolibrary.org/obo/GO_0060659 GO:0045020 biolink:BiologicalProcess obsolete error-prone DNA repair OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate. go.json error-prone DNA repair|mutagenic DNA repair True http://purl.obolibrary.org/obo/GO_0045020 GO:0045021 biolink:BiologicalProcess obsolete error-free DNA repair OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways. go.json error-free DNA repair True http://purl.obolibrary.org/obo/GO_0045021 GO:1901758 biolink:BiologicalProcess butirosin biosynthetic process The chemical reactions and pathways resulting in the formation of butirosin. go.json butirosin anabolism|butirosin biosynthesis|butirosin formation|butirosin synthesis http://purl.obolibrary.org/obo/GO_1901758 GO:1901759 biolink:BiologicalProcess beta-L-Ara4N-lipid A metabolic process The chemical reactions and pathways involving beta-L-Ara4N-lipid A. go.json 4-amino-4-deoxy-beta-L-arabinose-lipid A metabolic process|4-amino-4-deoxy-beta-L-arabinose-lipid A metabolism|beta-L-Ara4N-lipid A metabolism http://purl.obolibrary.org/obo/GO_1901759 GO:1901756 biolink:BiologicalProcess butirosin metabolic process The chemical reactions and pathways involving butirosin. go.json butirosin metabolism http://purl.obolibrary.org/obo/GO_1901756 GO:1901757 biolink:BiologicalProcess butirosin catabolic process The chemical reactions and pathways resulting in the breakdown of butirosin. go.json butirosin breakdown|butirosin catabolism|butirosin degradation http://purl.obolibrary.org/obo/GO_1901757 GO:1901754 biolink:BiologicalProcess vitamin D3 catabolic process The chemical reactions and pathways resulting in the breakdown of vitamin D3. go.json calciol breakdown|calciol catabolic process|calciol catabolism|calciol degradation|cholecalciferol catabolic process|cholecalciferol catabolism|vitamin D3 breakdown|vitamin D3 catabolism|vitamin D3 degradation http://purl.obolibrary.org/obo/GO_1901754 GO:0045028 biolink:MolecularActivity G protein-coupled purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled purinergic nucleotide receptor activity|G-protein coupled purinergic nucleotide receptor activity|P2Y|P2Y receptor|purinergic nucleotide receptor activity, G protein coupled|purinergic nucleotide receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0045028 GO:1901755 biolink:BiologicalProcess vitamin D3 biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin D3. go.json calciol anabolism|calciol biosynthesis|calciol biosynthetic process|calciol formation|calciol synthesis|cholecalciferol biosynthesis|cholecalciferol biosynthetic process|vitamin D3 anabolism|vitamin D3 biosynthesis|vitamin D3 formation|vitamin D3 synthesis http://purl.obolibrary.org/obo/GO_1901755 GO:0045029 biolink:MolecularActivity G protein-coupled UDP receptor activity Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP. go.json UDP-activated nucleotide receptor activity http://purl.obolibrary.org/obo/GO_0045029 GO:0045026 biolink:BiologicalProcess plasma membrane fusion The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. go.json cell fusion|cell-cell fusion http://purl.obolibrary.org/obo/GO_0045026 GO:1901752 biolink:BiologicalProcess leukotriene A4 catabolic process The chemical reactions and pathways resulting in the breakdown of leukotriene A4. go.json leukotriene A4 breakdown|leukotriene A4 catabolism|leukotriene A4 degradation http://purl.obolibrary.org/obo/GO_1901752 GO:1901753 biolink:BiologicalProcess leukotriene A4 biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene A4. go.json LTA4 biosynthesis|eoxin A4 biosynthesis|leukotriene A4 anabolism|leukotriene A4 biosynthesis|leukotriene A4 formation|leukotriene A4 synthesis http://purl.obolibrary.org/obo/GO_1901753 GO:0045027 biolink:MolecularActivity DNA end binding Binding to DNA ends exposed by the creation of double-strand breaks (DSBs). go.json http://purl.obolibrary.org/obo/GO_0045027 GO:0045024 biolink:MolecularActivity obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids. go.json peptidyl-glutamyl peptide hydrolyzing enzyme activity True http://purl.obolibrary.org/obo/GO_0045024 GO:1901750 biolink:BiologicalProcess leukotriene D4 biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene D4. go.json leukotriene D4 anabolism|leukotriene D4 biosynthesis|leukotriene D4 formation|leukotriene D4 synthesis http://purl.obolibrary.org/obo/GO_1901750 GO:0045025 biolink:CellularComponent mitochondrial degradosome A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer. go.json mtEXO http://purl.obolibrary.org/obo/GO_0045025 GO:1901751 biolink:BiologicalProcess leukotriene A4 metabolic process The chemical reactions and pathways involving leukotriene A4. go.json leukotriene A4 metabolism http://purl.obolibrary.org/obo/GO_1901751 GO:0045022 biolink:BiologicalProcess early endosome to late endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. go.json http://purl.obolibrary.org/obo/GO_0045022 GO:0045023 biolink:BiologicalProcess G0 to G1 transition The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. go.json http://purl.obolibrary.org/obo/GO_0045023 GO:0060640 biolink:BiologicalProcess positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud. go.json positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling|positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling http://purl.obolibrary.org/obo/GO_0060640 GO:0060641 biolink:BiologicalProcess mammary gland duct regression in males The process in which the epithelium of the mammary duct is destroyed in males. go.json http://purl.obolibrary.org/obo/GO_0060641 GO:0060642 biolink:BiologicalProcess white fat cell differentiation involved in mammary gland fat development The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. go.json http://purl.obolibrary.org/obo/GO_0060642 GO:0060643 biolink:BiologicalProcess epithelial cell differentiation involved in mammary gland bud morphogenesis The process in which a cell of the mammary placode becomes a cell of the mammary gland bud. go.json http://purl.obolibrary.org/obo/GO_0060643 GO:0060644 biolink:BiologicalProcess mammary gland epithelial cell differentiation The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. go.json http://purl.obolibrary.org/obo/GO_0060644 GO:0060645 biolink:BiologicalProcess peripheral mammary gland bud epithelial cell differentiation The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically. go.json http://purl.obolibrary.org/obo/GO_0060645 GO:0060646 biolink:BiologicalProcess internal mammary gland bud epithelial cell differentiation The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape. go.json http://purl.obolibrary.org/obo/GO_0060646 GO:0060647 biolink:BiologicalProcess mesenchymal cell condensation involved in mammary fat development The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development. go.json http://purl.obolibrary.org/obo/GO_0060647 GO:0060648 biolink:BiologicalProcess mammary gland bud morphogenesis The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord. go.json http://purl.obolibrary.org/obo/GO_0060648 GO:0060649 biolink:BiologicalProcess mammary gland bud elongation The process in which the mammary gland bud grows along its axis. go.json http://purl.obolibrary.org/obo/GO_0060649 GO:0045031 biolink:MolecularActivity G protein-coupled ATP receptor activity Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json ATP-activated adenosine receptor activity|ATP-activated nucleotide receptor activity http://purl.obolibrary.org/obo/GO_0045031 GO:0045032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045032 GO:0045030 biolink:MolecularActivity G protein-coupled UTP receptor activity Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP. go.json UTP-activated nucleotide receptor activity|purinoceptor type U|uridine nucleotide receptor activity http://purl.obolibrary.org/obo/GO_0045030 GO:1901769 biolink:BiologicalProcess carbapenem biosynthetic process The chemical reactions and pathways resulting in the formation of carbapenem. go.json carbapenem anabolism|carbapenem biosynthesis|carbapenem formation|carbapenem synthesis http://purl.obolibrary.org/obo/GO_1901769 GO:1901767 biolink:BiologicalProcess carbapenem metabolic process The chemical reactions and pathways involving carbapenem. go.json carbapenem metabolism http://purl.obolibrary.org/obo/GO_1901767 GO:1901768 biolink:BiologicalProcess carbapenem catabolic process The chemical reactions and pathways resulting in the breakdown of carbapenem. go.json carbapenem breakdown|carbapenem catabolism|carbapenem degradation http://purl.obolibrary.org/obo/GO_1901768 GO:1901765 biolink:BiologicalProcess phosphinothricin catabolic process The chemical reactions and pathways resulting in the breakdown of phosphinothricin. go.json phosphinothricin breakdown|phosphinothricin catabolism|phosphinothricin degradation http://purl.obolibrary.org/obo/GO_1901765 GO:0045039 biolink:BiologicalProcess protein insertion into mitochondrial inner membrane The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane. go.json mitochondrial inner membrane protein import|protein import into mitochondrial inner membrane|protein transport into mitochondrial inner membrane http://purl.obolibrary.org/obo/GO_0045039 GO:1901766 biolink:BiologicalProcess phosphinothricin biosynthetic process The chemical reactions and pathways resulting in the formation of phosphinothricin. go.json phosphinothricin anabolism|phosphinothricin biosynthesis|phosphinothricin formation|phosphinothricin synthesis http://purl.obolibrary.org/obo/GO_1901766 GO:1901763 biolink:BiologicalProcess oxytetracycline biosynthetic process The chemical reactions and pathways resulting in the formation of oxytetracycline. go.json oxytetracycline anabolism|oxytetracycline biosynthesis|oxytetracycline formation|oxytetracycline synthesis http://purl.obolibrary.org/obo/GO_1901763 GO:0045037 biolink:BiologicalProcess protein import into chloroplast stroma The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import. go.json chloroplast stroma protein import|protein transport into chloroplast stroma http://purl.obolibrary.org/obo/GO_0045037 GO:0045038 biolink:BiologicalProcess protein import into chloroplast thylakoid membrane The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma. go.json chloroplast thylakoid membrane protein import|protein transport into chloroplast thylakoid membrane http://purl.obolibrary.org/obo/GO_0045038 GO:1901764 biolink:BiologicalProcess phosphinothricin metabolic process The chemical reactions and pathways involving phosphinothricin. go.json phosphinothricin metabolism http://purl.obolibrary.org/obo/GO_1901764 GO:1901761 biolink:BiologicalProcess oxytetracycline metabolic process The chemical reactions and pathways involving oxytetracycline. go.json oxytetracycline metabolism http://purl.obolibrary.org/obo/GO_1901761 GO:0045035 biolink:BiologicalProcess sensory organ precursor cell division The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron). go.json sense organ precursor cell division http://purl.obolibrary.org/obo/GO_0045035 GO:0045036 biolink:BiologicalProcess protein targeting to chloroplast The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved. go.json protein-chloroplast targeting http://purl.obolibrary.org/obo/GO_0045036 GO:1901762 biolink:BiologicalProcess oxytetracycline catabolic process The chemical reactions and pathways resulting in the breakdown of oxytetracycline. go.json oxytetracycline breakdown|oxytetracycline catabolism|oxytetracycline degradation http://purl.obolibrary.org/obo/GO_1901762 GO:0060670 biolink:BiologicalProcess branching involved in labyrinthine layer morphogenesis The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. go.json http://purl.obolibrary.org/obo/GO_0060670 GO:0045033 biolink:BiologicalProcess peroxisome inheritance The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p. go.json http://purl.obolibrary.org/obo/GO_0045033 GO:1901760 biolink:BiologicalProcess beta-L-Ara4N-lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of beta-L-Ara4N-lipid A which occurs as a result of modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N). This strategy is adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system. go.json 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis|4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthetic process|beta-L-Ara4N-lipid A anabolism|beta-L-Ara4N-lipid A biosynthesis|beta-L-Ara4N-lipid A formation|beta-L-Ara4N-lipid A synthesis http://purl.obolibrary.org/obo/GO_1901760 GO:0045034 biolink:BiologicalProcess obsolete neuroblast division OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell. go.json neuroblast cell division|neuroblast division|neuroblast division (sensu Nematoda and Protostomia)|neuroblast division (sensu Vertebrata) True http://purl.obolibrary.org/obo/GO_0045034 GO:0060671 biolink:BiologicalProcess epithelial cell differentiation involved in embryonic placenta development The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer. go.json http://purl.obolibrary.org/obo/GO_0060671 GO:0060672 biolink:BiologicalProcess epithelial cell morphogenesis involved in placental branching The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta. go.json http://purl.obolibrary.org/obo/GO_0060672 GO:0060673 biolink:BiologicalProcess cell-cell signaling involved in placenta development Any process that mediates the transfer of information from one cell to another. go.json cell-cell signalling involved in placenta development http://purl.obolibrary.org/obo/GO_0060673 GO:0060674 biolink:BiologicalProcess placenta blood vessel development The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060674 GO:0060675 biolink:BiologicalProcess ureteric bud morphogenesis The process in which the ureteric bud is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060675 GO:0060676 biolink:BiologicalProcess ureteric bud formation The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud. go.json http://purl.obolibrary.org/obo/GO_0060676 GO:0060677 biolink:BiologicalProcess ureteric bud elongation The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated. go.json http://purl.obolibrary.org/obo/GO_0060677 GO:0060678 biolink:BiologicalProcess dichotomous subdivision of terminal units involved in ureteric bud branching The process in which a ureteric bud bifurcates at its end. go.json bifid subdivision of terminal units involved in ureteric bud branching http://purl.obolibrary.org/obo/GO_0060678 GO:0060679 biolink:BiologicalProcess trifid subdivision of terminal units involved in ureteric bud branching The process in which a ureteric bud splits into three units at its end. go.json http://purl.obolibrary.org/obo/GO_0060679 GO:0045042 biolink:BiologicalProcess obsolete protein import into mitochondrial intermembrane space, conservative OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space. go.json conservative mitochondrial IMS protein import|conservative mitochondrial intermembrane space protein import|conservative protein transport into mitochondrial IMS|conservative protein transport into mitochondrial intermembrane space|protein import into mitochondrial IMS, conservative|protein import into mitochondrial intermembrane space, conservative|protein transport into mitochondrial IMS, conservative|protein transport into mitochondrial intermembrane space, conservative True http://purl.obolibrary.org/obo/GO_0045042 GO:0045043 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045043 GO:0045040 biolink:BiologicalProcess protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes. go.json mitochondrial outer membrane protein import|protein import into mitochondrial outer membrane|protein transport into mitochondrial outer membrane http://purl.obolibrary.org/obo/GO_0045040 GO:0045041 biolink:BiologicalProcess protein import into mitochondrial intermembrane space The import of proteins into the space between the inner and outer mitochondrial membranes. go.json mitochondrial intermembrane space protein import|protein import into mitochondrial IMS|protein import into mitochondrial intermembrane space, direct|protein import into mitochondrial intermembrane space, nonconservative|protein transport into mitochondrial IMS|protein transport into mitochondrial intermembrane space http://purl.obolibrary.org/obo/GO_0045041 GO:1901778 biolink:BiologicalProcess pentalenolactone metabolic process The chemical reactions and pathways involving pentalenolactone. go.json pentalenolactone metabolism http://purl.obolibrary.org/obo/GO_1901778 GO:1901779 biolink:BiologicalProcess pentalenolactone catabolic process The chemical reactions and pathways resulting in the breakdown of pentalenolactone. go.json pentalenolactone breakdown|pentalenolactone catabolism|pentalenolactone degradation http://purl.obolibrary.org/obo/GO_1901779 GO:1901776 biolink:BiologicalProcess mitomycin C catabolic process The chemical reactions and pathways resulting in the breakdown of mitomycin C. go.json mitomycin C breakdown|mitomycin C catabolism|mitomycin C degradation http://purl.obolibrary.org/obo/GO_1901776 GO:1901777 biolink:BiologicalProcess mitomycin C biosynthetic process The chemical reactions and pathways resulting in the formation of mitomycin C. go.json mitomycin C anabolism|mitomycin C biosynthesis|mitomycin C formation|mitomycin C synthesis http://purl.obolibrary.org/obo/GO_1901777 GO:0045048 biolink:BiologicalProcess protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. go.json integral ER membrane protein localization|integral ER membrane protein positioning|localization of protein in ER membrane|positioning of protein in ER membrane|protein insertion into endoplasmic reticulum membrane|protein-ER insertion|protein-endoplasmic reticulum insertion http://purl.obolibrary.org/obo/GO_0045048 GO:1901774 biolink:BiologicalProcess lincomycin biosynthetic process The chemical reactions and pathways resulting in the formation of lincomycin. go.json lincomycin anabolism|lincomycin biosynthesis|lincomycin formation|lincomycin synthesis http://purl.obolibrary.org/obo/GO_1901774 GO:1901775 biolink:BiologicalProcess mitomycin C metabolic process The chemical reactions and pathways involving mitomycin C. go.json mitomycin C metabolism http://purl.obolibrary.org/obo/GO_1901775 GO:0045049 biolink:BiologicalProcess protein insertion into ER membrane by N-terminal cleaved signal sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER. go.json N-terminal cleaved signal sequence mediated protein insertion into ER membrane|protein insertion into ER membrane, N-terminal cleaved signal sequence mediated|protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence|protein-ER insertion by N-terminal cleaved signal sequence|protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence http://purl.obolibrary.org/obo/GO_0045049 GO:1901772 biolink:BiologicalProcess lincomycin metabolic process The chemical reactions and pathways involving lincomycin. go.json lincomycin metabolism http://purl.obolibrary.org/obo/GO_1901772 GO:0045046 biolink:BiologicalProcess protein import into peroxisome membrane The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. go.json peroxisome membrane protein import|protein transport into peroxisome membrane http://purl.obolibrary.org/obo/GO_0045046 GO:1901773 biolink:BiologicalProcess lincomycin catabolic process The chemical reactions and pathways resulting in the breakdown of lincomycin. go.json lincomycin breakdown|lincomycin catabolism|lincomycin degradation http://purl.obolibrary.org/obo/GO_1901773 GO:0045047 biolink:BiologicalProcess protein targeting to ER The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. go.json protein targeting to endoplasmic reticulum|protein-ER targeting|protein-endoplasmic reticulum targeting http://purl.obolibrary.org/obo/GO_0045047 GO:1901770 biolink:BiologicalProcess daunorubicin catabolic process The chemical reactions and pathways resulting in the breakdown of daunorubicin. go.json daunorubicin breakdown|daunorubicin catabolism|daunorubicin degradation http://purl.obolibrary.org/obo/GO_1901770 GO:0045044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045044 GO:0060660 biolink:BiologicalProcess epidermis morphogenesis involved in nipple formation The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection. go.json http://purl.obolibrary.org/obo/GO_0060660 GO:1901771 biolink:BiologicalProcess daunorubicin biosynthetic process The chemical reactions and pathways resulting in the formation of daunorubicin. go.json daunorubicin anabolism|daunorubicin biosynthesis|daunorubicin formation|daunorubicin synthesis http://purl.obolibrary.org/obo/GO_1901771 GO:0045045 biolink:BiologicalProcess obsolete secretory pathway OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane. go.json secretory pathway True http://purl.obolibrary.org/obo/GO_0045045 GO:0060661 biolink:BiologicalProcess submandibular salivary gland formation The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed. go.json http://purl.obolibrary.org/obo/GO_0060661 GO:0060662 biolink:BiologicalProcess salivary gland cavitation The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland. go.json salivary gland invagination http://purl.obolibrary.org/obo/GO_0060662 GO:1901780 biolink:BiologicalProcess pentalenolactone biosynthetic process The chemical reactions and pathways resulting in the formation of pentalenolactone. go.json pentalenolactone anabolism|pentalenolactone biosynthesis|pentalenolactone formation|pentalenolactone synthesis http://purl.obolibrary.org/obo/GO_1901780 GO:0060663 biolink:BiologicalProcess apoptotic process involved in salivary gland cavitation Any apoptotic process in which the solid core of the gland is hollowed out to form the duct. go.json apoptosis involved in salivary gland cavitation http://purl.obolibrary.org/obo/GO_0060663 GO:0060664 biolink:BiologicalProcess epithelial cell proliferation involved in salivary gland morphogenesis The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland. go.json http://purl.obolibrary.org/obo/GO_0060664 GO:0060665 biolink:BiologicalProcess regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium. go.json regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling http://purl.obolibrary.org/obo/GO_0060665 GO:0060666 biolink:BiologicalProcess dichotomous subdivision of terminal units involved in salivary gland branching The process in which a salivary epithelial cord bifurcates at its end. go.json http://purl.obolibrary.org/obo/GO_0060666 GO:0060667 biolink:BiologicalProcess branch elongation involved in salivary gland morphogenesis The differential growth of the salivary branches along their axis, resulting in the growth of a branch. go.json http://purl.obolibrary.org/obo/GO_0060667 GO:0060668 biolink:BiologicalProcess regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland. go.json regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling http://purl.obolibrary.org/obo/GO_0060668 GO:0060669 biolink:BiologicalProcess embryonic placenta morphogenesis The process in which the embryonic placenta is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060669 GO:0045053 biolink:BiologicalProcess protein retention in Golgi apparatus The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known. go.json maintenance of protein location in Golgi apparatus|protein-Golgi retention|retention of protein in Golgi http://purl.obolibrary.org/obo/GO_0045053 GO:0070010 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070010 GO:0045054 biolink:BiologicalProcess constitutive secretory pathway A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space. go.json constitutive exocytosis http://purl.obolibrary.org/obo/GO_0045054 GO:0045051 biolink:BiologicalProcess protein insertion into ER membrane by internal uncleaved signal-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences. go.json internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane|protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated|protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence|protein-ER insertion by internal uncleaved signal-anchor sequence|protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence http://purl.obolibrary.org/obo/GO_0045051 GO:0045052 biolink:BiologicalProcess obsolete protein insertion into ER membrane by GPI attachment sequence OBSOLETE. A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule. go.json GPI attachment sequence mediated protein insertion into ER membrane|protein insertion into ER membrane, GPI attachment sequence mediated|protein insertion into endoplasmic reticulum membrane by GPI attachment sequence|protein-ER insertion by GPI attachment sequence|protein-endoplasmic reticulum insertion by GPI attachment sequence True http://purl.obolibrary.org/obo/GO_0045052 GO:0045050 biolink:BiologicalProcess protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix. go.json protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated|protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence|protein-ER insertion by stop-transfer membrane-anchor sequence|protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence|stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane http://purl.obolibrary.org/obo/GO_0045050 GO:1901789 biolink:BiologicalProcess benzoyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of benzoyl-CoA. go.json benzoyl-CoA anabolism|benzoyl-CoA biosynthesis|benzoyl-CoA formation|benzoyl-CoA synthesis http://purl.obolibrary.org/obo/GO_1901789 GO:1901787 biolink:BiologicalProcess benzoyl-CoA metabolic process The chemical reactions and pathways involving benzoyl-CoA. go.json benzoyl-CoA metabolism http://purl.obolibrary.org/obo/GO_1901787 GO:1901788 biolink:BiologicalProcess benzoyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA. go.json benzoyl-CoA breakdown|benzoyl-CoA catabolism|benzoyl-CoA degradation http://purl.obolibrary.org/obo/GO_1901788 GO:1901785 biolink:BiologicalProcess p-cresol catabolic process The chemical reactions and pathways resulting in the breakdown of p-cresol. go.json p-cresol breakdown|p-cresol catabolism|p-cresol degradation http://purl.obolibrary.org/obo/GO_1901785 GO:0045059 biolink:BiologicalProcess positive thymic T cell selection The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. go.json positive thymic T lymphocyte selection|positive thymic T-cell selection|positive thymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045059 GO:1901786 biolink:BiologicalProcess p-cresol biosynthetic process The chemical reactions and pathways resulting in the formation of p-cresol. go.json p-cresol anabolism|p-cresol biosynthesis|p-cresol formation|p-cresol synthesis http://purl.obolibrary.org/obo/GO_1901786 GO:0045057 biolink:BiologicalProcess cisternal progression The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna. go.json cisternal maturation http://purl.obolibrary.org/obo/GO_0045057 GO:1901783 biolink:BiologicalProcess p-cumate biosynthetic process The chemical reactions and pathways resulting in the formation of p-cumate. go.json p-cumate anabolism|p-cumate biosynthesis|p-cumate formation|p-cumate synthesis http://purl.obolibrary.org/obo/GO_1901783 GO:0060690 biolink:BiologicalProcess epithelial cell differentiation involved in salivary gland development The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland. go.json http://purl.obolibrary.org/obo/GO_0060690 GO:0060691 biolink:BiologicalProcess epithelial cell maturation involved in salivary gland development The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0060691 GO:0045058 biolink:BiologicalProcess T cell selection The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. Wikipedia:Thymocyte go.json T lymphocyte selection|T-cell selection|T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045058 GO:1901784 biolink:BiologicalProcess p-cresol metabolic process The chemical reactions and pathways involving p-cresol. go.json p-cresol metabolism http://purl.obolibrary.org/obo/GO_1901784 GO:1901781 biolink:BiologicalProcess p-cumate metabolic process The chemical reactions and pathways involving p-cumate. go.json p-cumate metabolism http://purl.obolibrary.org/obo/GO_1901781 GO:0045055 biolink:BiologicalProcess regulated exocytosis A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. go.json regulated secretory pathway http://purl.obolibrary.org/obo/GO_0045055 GO:0060692 biolink:BiologicalProcess mesenchymal cell differentiation involved in salivary gland development The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. go.json http://purl.obolibrary.org/obo/GO_0060692 GO:0045056 biolink:BiologicalProcess transcytosis The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Wikipedia:Transcytosis go.json http://purl.obolibrary.org/obo/GO_0045056 GO:1901782 biolink:BiologicalProcess p-cumate catabolic process The chemical reactions and pathways resulting in the breakdown of p-cumate. go.json p-cumate breakdown|p-cumate catabolism|p-cumate degradation http://purl.obolibrary.org/obo/GO_1901782 GO:0060693 biolink:BiologicalProcess regulation of branching involved in salivary gland morphogenesis Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium. go.json http://purl.obolibrary.org/obo/GO_0060693 GO:0060694 biolink:BiologicalProcess regulation of cholesterol transporter activity Any process that modulates the rate, frequency, or extent of cholesterol transporter activity. go.json http://purl.obolibrary.org/obo/GO_0060694 gocheck_do_not_annotate GO:1901790 biolink:BiologicalProcess 3-(2,3-dihydroxyphenyl)propanoate metabolic process The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate. go.json 3-(2,3-dihydroxyphenyl)propanoate metabolism http://purl.obolibrary.org/obo/GO_1901790 GO:0060695 biolink:BiologicalProcess negative regulation of cholesterol transporter activity Any process that decreases the rate, frequency, or extent of cholesterol transporter activity. go.json http://purl.obolibrary.org/obo/GO_0060695 gocheck_do_not_annotate GO:1901791 biolink:BiologicalProcess 3-(2,3-dihydroxyphenyl)propanoate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(2,3-dihydroxyphenyl)propanoate. go.json 3-(2,3-dihydroxyphenyl)propanoate breakdown|3-(2,3-dihydroxyphenyl)propanoate catabolism|3-(2,3-dihydroxyphenyl)propanoate degradation http://purl.obolibrary.org/obo/GO_1901791 GO:0060696 biolink:BiologicalProcess regulation of phospholipid catabolic process Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. go.json http://purl.obolibrary.org/obo/GO_0060696 GO:0060697 biolink:BiologicalProcess positive regulation of phospholipid catabolic process Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. go.json http://purl.obolibrary.org/obo/GO_0060697 GO:0060698 biolink:MolecularActivity endoribonuclease inhibitor activity Binds to and stops, prevents or reduces the activity of endoribonuclease. go.json http://purl.obolibrary.org/obo/GO_0060698 GO:0060699 biolink:BiologicalProcess regulation of endoribonuclease activity Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. go.json http://purl.obolibrary.org/obo/GO_0060699 gocheck_do_not_annotate GO:0070019 biolink:CellularComponent obsolete transforming growth factor beta type II receptor homodimeric complex OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers. go.json TGF-beta type II receptor complex|TGF-beta type II receptor dimer|TGFBR2 homodimer|transforming growth factor beta type II receptor complex True http://purl.obolibrary.org/obo/GO_0070019 GO:0070017 biolink:CellularComponent alphav-beta3 integrin-thrombospondin complex A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin. go.json ITGAV-ITGB3-THBS1 complex http://purl.obolibrary.org/obo/GO_0070017 GO:0070018 biolink:CellularComponent obsolete transforming growth factor beta type I receptor homodimeric complex OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers. go.json TGF-beta type I receptor complex|TGF-beta type I receptor dimer|TGFBR1 homodimer|transforming growth factor beta type I receptor complex True http://purl.obolibrary.org/obo/GO_0070018 GO:0070015 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070015 GO:0070016 biolink:MolecularActivity armadillo repeat domain binding Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation. go.json Arm repeat domain binding|armadillo domain binding|armadillo repeat binding http://purl.obolibrary.org/obo/GO_0070016 GO:0070013 biolink:CellularComponent intracellular organelle lumen An organelle lumen that is part of an intracellular organelle. go.json http://purl.obolibrary.org/obo/GO_0070013 GO:0070014 biolink:CellularComponent sucrase-isomaltase complex A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities. Wikipedia:Sucrase-isomaltase go.json oligo-1,6-glucosidase complex http://purl.obolibrary.org/obo/GO_0070014 GO:0070011 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070011 GO:0070012 biolink:MolecularActivity oligopeptidase activity Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds. go.json http://purl.obolibrary.org/obo/GO_0070012 GO:0045064 biolink:BiologicalProcess T-helper 2 cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4. go.json T-helper 2 cell development http://purl.obolibrary.org/obo/GO_0045064 GO:0045065 biolink:BiologicalProcess cytotoxic T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell. go.json cytotoxic T cell development|cytotoxic T lymphocyte selection|cytotoxic T-cell selection|cytotoxic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045065 GO:0045062 biolink:BiologicalProcess extrathymic T cell selection The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus. go.json extrathymic T lymphocyte selection|extrathymic T-cell selection|extrathymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045062 GO:0045063 biolink:BiologicalProcess T-helper 1 cell differentiation The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. go.json T-helper 1 cell development http://purl.obolibrary.org/obo/GO_0045063 GO:0045060 biolink:BiologicalProcess negative thymic T cell selection The process of elimination of immature T cells in the thymus which react strongly with self-antigens. go.json negative thymic T lymphocyte selection|negative thymic T-cell selection|negative thymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045060 GO:0045061 biolink:BiologicalProcess thymic T cell selection The process of T cell selection that occurs in the thymus. go.json thymic T lymphocyte selection|thymic T-cell selection|thymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045061 GO:1901798 biolink:BiologicalProcess positive regulation of signal transduction by p53 class mediator Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. go.json activation of signal transduction by p53 class mediator|up regulation of signal transduction by p53 class mediator|up-regulation of signal transduction by p53 class mediator|upregulation of signal transduction by p53 class mediator http://purl.obolibrary.org/obo/GO_1901798 GO:1901799 biolink:BiologicalProcess negative regulation of proteasomal protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process. go.json down regulation of proteasomal protein catabolic process|down regulation of proteasome-mediated protein catabolic process|down regulation of proteasome-mediated protein catabolism|down-regulation of proteasomal protein catabolic process|down-regulation of proteasome-mediated protein catabolic process|down-regulation of proteasome-mediated protein catabolism|downregulation of proteasomal protein catabolic process|downregulation of proteasome-mediated protein catabolic process|downregulation of proteasome-mediated protein catabolism|inhibition of proteasomal protein catabolic process|inhibition of proteasome-mediated protein catabolic process|inhibition of proteasome-mediated protein catabolism|negative regulation of proteasome-mediated protein catabolic process|negative regulation of proteasome-mediated protein catabolism http://purl.obolibrary.org/obo/GO_1901799 GO:1901796 biolink:BiologicalProcess regulation of signal transduction by p53 class mediator Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. go.json http://purl.obolibrary.org/obo/GO_1901796 GO:1901797 biolink:BiologicalProcess negative regulation of signal transduction by p53 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. go.json down regulation of signal transduction by p53 class mediator|down-regulation of signal transduction by p53 class mediator|downregulation of signal transduction by p53 class mediator|inhibition of signal transduction by p53 class mediator http://purl.obolibrary.org/obo/GO_1901797 GO:1901794 biolink:BiologicalProcess 3-(3-hydroxyphenyl)propanoate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate. go.json 3-(3-hydroxyphenyl)propanoate breakdown|3-(3-hydroxyphenyl)propanoate catabolism|3-(3-hydroxyphenyl)propanoate degradation http://purl.obolibrary.org/obo/GO_1901794 GO:0045068 biolink:BiologicalProcess negative extrathymic T cell selection The process of elimination of extrathymically maturing T cells which react strongly with self-antigens. go.json negative extrathymic T lymphocyte selection|negative extrathymic T-cell selection|negative extrathymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045068 GO:1901795 biolink:BiologicalProcess 3-(3-hydroxyphenyl)propanoate biosynthetic process The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate. go.json 3-(3-hydroxyphenyl)propanoate anabolism|3-(3-hydroxyphenyl)propanoate biosynthesis|3-(3-hydroxyphenyl)propanoate formation|3-(3-hydroxyphenyl)propanoate synthesis http://purl.obolibrary.org/obo/GO_1901795 GO:0060680 biolink:BiologicalProcess lateral sprouting involved in ureteric bud morphogenesis The process in which a branch forms along the side of a ureteric bud. go.json http://purl.obolibrary.org/obo/GO_0060680 GO:0045069 biolink:BiologicalProcess regulation of viral genome replication Any process that modulates the frequency, rate or extent of viral genome replication. go.json http://purl.obolibrary.org/obo/GO_0045069 GO:1901792 biolink:BiologicalProcess 3-(2,3-dihydroxyphenyl)propanoate biosynthetic process The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate. go.json 3-(2,3-dihydroxyphenyl)propanoate anabolism|3-(2,3-dihydroxyphenyl)propanoate biosynthesis|3-(2,3-dihydroxyphenyl)propanoate formation|3-(2,3-dihydroxyphenyl)propanoate synthesis http://purl.obolibrary.org/obo/GO_1901792 GO:0045066 biolink:BiologicalProcess regulatory T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. go.json regulatory T cell development|regulatory T lymphocyte differentiation|regulatory T-cell differentiation|regulatory T-lymphocyte differentiation|suppressor T cell differentiation|suppressor T lymphocyte differentiation|suppressor T-cell differentiation|suppressor T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045066 GO:0060681 biolink:BiologicalProcess branch elongation involved in ureteric bud branching The growth of a branch of the ureteric bud along its axis. go.json http://purl.obolibrary.org/obo/GO_0060681 GO:1901793 biolink:BiologicalProcess 3-(3-hydroxyphenyl)propanoate metabolic process The chemical reactions and pathways involving 3-(3-hydroxyphenyl)propanoate. go.json 3-(3-hydroxyphenyl)propanoate metabolism http://purl.obolibrary.org/obo/GO_1901793 GO:0045067 biolink:BiologicalProcess positive extrathymic T cell selection The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. go.json positive extrathymic T lymphocyte selection|positive extrathymic T-cell selection|positive extrathymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0045067 GO:0060682 biolink:BiologicalProcess primary ureteric bud growth The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema. go.json http://purl.obolibrary.org/obo/GO_0060682 GO:0060683 biolink:BiologicalProcess regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland. go.json regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling http://purl.obolibrary.org/obo/GO_0060683 GO:0060684 biolink:BiologicalProcess epithelial-mesenchymal cell signaling Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. go.json epithelial-mesenchymal cell signalling http://purl.obolibrary.org/obo/GO_0060684 GO:0060685 biolink:BiologicalProcess regulation of prostatic bud formation Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. go.json http://purl.obolibrary.org/obo/GO_0060685 GO:0060686 biolink:BiologicalProcess negative regulation of prostatic bud formation Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. go.json http://purl.obolibrary.org/obo/GO_0060686 GO:0060687 biolink:BiologicalProcess regulation of branching involved in prostate gland morphogenesis Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. go.json http://purl.obolibrary.org/obo/GO_0060687 GO:0060688 biolink:BiologicalProcess regulation of morphogenesis of a branching structure Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060688 GO:0070008 biolink:MolecularActivity serine-type exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). go.json http://purl.obolibrary.org/obo/GO_0070008 GO:0060689 biolink:BiologicalProcess cell differentiation involved in salivary gland development The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland. go.json http://purl.obolibrary.org/obo/GO_0060689 GO:0070009 biolink:MolecularActivity serine-type aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). go.json http://purl.obolibrary.org/obo/GO_0070009 GO:0070006 biolink:MolecularActivity metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. go.json http://purl.obolibrary.org/obo/GO_0070006 GO:0070007 biolink:MolecularActivity glutamic-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. go.json http://purl.obolibrary.org/obo/GO_0070007 GO:0070004 biolink:MolecularActivity cysteine-type exopeptidase activity Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. go.json http://purl.obolibrary.org/obo/GO_0070004 GO:0070005 biolink:MolecularActivity cysteine-type aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. go.json http://purl.obolibrary.org/obo/GO_0070005 GO:0070002 biolink:MolecularActivity glutamic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. go.json http://purl.obolibrary.org/obo/GO_0070002 GO:0070003 biolink:MolecularActivity threonine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. go.json http://purl.obolibrary.org/obo/GO_0070003 GO:0070001 biolink:MolecularActivity aspartic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. go.json http://purl.obolibrary.org/obo/GO_0070001 GO:0035823 biolink:BiologicalProcess short tract gene conversion A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor. go.json http://purl.obolibrary.org/obo/GO_0035823 GO:0035824 biolink:BiologicalProcess long tract gene conversion A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor. go.json http://purl.obolibrary.org/obo/GO_0035824 GO:0035825 biolink:BiologicalProcess homologous recombination A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules. Wikipedia:Chromosomal_crossover go.json chromosomal crossover|interchromosomal DNA recombination|interstrand DNA recombination|reciprocal DNA recombination http://purl.obolibrary.org/obo/GO_0035825 GO:0035826 biolink:BiologicalProcess obsolete rubidium ion transport OBSOLETE. The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json Rb+ transport|rubidium cation transport True http://purl.obolibrary.org/obo/GO_0035826 GO:0035827 biolink:MolecularActivity obsolete rubidium ion transmembrane transporter activity OBSOLETE. Enables the transfer of rubidium ions (Rb+) from one side of a membrane to the other. go.json Rb+ transmembrane transporter activity|rubidium cation transmembrane transporter activity|rubidium transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_0035827 GO:0035828 biolink:BiologicalProcess obsolete renal rubidium ion transport OBSOLETE. The directed movement of rubidium ions (Rb+) by the kidney. go.json renal Rb+ transport|renal rubidium cation transport True http://purl.obolibrary.org/obo/GO_0035828 GO:0035829 biolink:BiologicalProcess obsolete renal rubidium ion absorption OBSOLETE. A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. go.json renal Rb+ absorption|renal rubidium cation absorption True http://purl.obolibrary.org/obo/GO_0035829 GO:0035820 biolink:BiologicalProcess negative regulation of renal sodium excretion by angiotensin The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time. go.json http://purl.obolibrary.org/obo/GO_0035820 GO:0035821 biolink:BiologicalProcess modulation of process of another organism The process in which an organism effects a change in the structure or processes of another organism. go.json modification of morphology or physiology of other organism|modulation of process of other organism|regulation of morphology of other organism|regulation of morphology or physiology of other organism|regulation of physiological process of other organism|regulation of physiology of other organism http://purl.obolibrary.org/obo/GO_0035821 GO:0035822 biolink:BiologicalProcess gene conversion A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. The resulting acceptor sequence is identical to that of the donor. go.json http://purl.obolibrary.org/obo/GO_0035822 GO:0035812 biolink:BiologicalProcess renal sodium excretion The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. go.json http://purl.obolibrary.org/obo/GO_0035812 GO:0035813 biolink:BiologicalProcess regulation of renal sodium excretion Any process that modulates the amount of sodium excreted in urine over a unit of time. go.json http://purl.obolibrary.org/obo/GO_0035813 GO:0035814 biolink:BiologicalProcess negative regulation of renal sodium excretion Any process that decreases the amount of sodium excreted in urine over a unit of time. go.json http://purl.obolibrary.org/obo/GO_0035814 GO:0035815 biolink:BiologicalProcess positive regulation of renal sodium excretion Any process that increases the amount of sodium excreted in urine over a unit of time. go.json natriuresis http://purl.obolibrary.org/obo/GO_0035815 GO:0035816 biolink:BiologicalProcess obsolete renal water absorption involved in negative regulation of urine volume OBSOLETE. Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time. go.json True http://purl.obolibrary.org/obo/GO_0035816 GO:0035817 biolink:BiologicalProcess renal sodium ion absorption involved in negative regulation of renal sodium excretion Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time. go.json http://purl.obolibrary.org/obo/GO_0035817 GO:0035818 biolink:BiologicalProcess positive regulation of urine volume by pressure natriuresis An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis. go.json diuresis resulting from pressure natriuresis http://purl.obolibrary.org/obo/GO_0035818 GO:0035819 biolink:BiologicalProcess positive regulation of renal sodium excretion by pressure natriuresis An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis. go.json natriuresis resulting from pressure natriuresis http://purl.obolibrary.org/obo/GO_0035819 GO:0035810 biolink:BiologicalProcess positive regulation of urine volume Any process that increases the amount of urine excreted from the body over a unit of time. go.json diuresis|elevation of urinary volume|increase in urine flow http://purl.obolibrary.org/obo/GO_0035810 GO:0035811 biolink:BiologicalProcess negative regulation of urine volume Any process that decreases the amount of urine excreted from the body over a unit of time. go.json antidiuresis|decrease in urine flow|reduction of urinary volume http://purl.obolibrary.org/obo/GO_0035811 GO:0060809 biolink:BiologicalProcess mesodermal to mesenchymal transition involved in gastrulation The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0060809 GO:0035809 biolink:BiologicalProcess regulation of urine volume Any process that modulates the amount of urine excreted from the body over a unit of time. go.json regulation of urinary volume|regulation of urine flow http://purl.obolibrary.org/obo/GO_0035809 GO:0035801 biolink:BiologicalProcess adrenal cortex development The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens). go.json adrenal gland cortex development http://purl.obolibrary.org/obo/GO_0035801 GO:0035802 biolink:BiologicalProcess adrenal cortex formation The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate). go.json adrenal gland cortex formation http://purl.obolibrary.org/obo/GO_0035802 GO:0035803 biolink:BiologicalProcess egg coat formation Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. go.json VE formation|ZP assembly|vitelline envelope formation|zona pellucida assembly http://purl.obolibrary.org/obo/GO_0035803 GO:0035804 biolink:MolecularActivity structural constituent of egg coat The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. go.json structural constituent of vitelline envelope|structural constituent of zona pellucida http://purl.obolibrary.org/obo/GO_0035804 GO:0035805 biolink:CellularComponent egg coat A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. go.json vitelline membrane|zona pellucida http://purl.obolibrary.org/obo/GO_0035805 GO:0035806 biolink:BiologicalProcess perturbation of blood coagulation in another organism The process in which an organism effects a change that affects blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. go.json modulation by organism of blood clotting in other organism|modulation by organism of blood coagulation in other organism|modulation of blood coagulation in another organism|modulation of blood coagulation in other organism|perturbation of blood clotting in another organism|regulation by organism of blood clotting in other organism|regulation of blood clotting in other organism|regulation of blood coagulation in other organism http://purl.obolibrary.org/obo/GO_0035806 GO:0035807 biolink:BiologicalProcess induction of blood coagulation in another organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. go.json induction of blood clotting in another organism|positive regulation by organism of blood clotting in other organism|positive regulation by organism of blood coagulation in other organism|positive regulation of blood clotting in other organism|positive regulation of blood coagulation in another organism|positive regulation of blood coagulation in other organism http://purl.obolibrary.org/obo/GO_0035807 GO:0035808 biolink:CellularComponent meiotic recombination initiation complex A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins. go.json http://purl.obolibrary.org/obo/GO_0035808 GO:0060810 biolink:BiologicalProcess intracellular mRNA localization involved in pattern specification process Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo. go.json intracellular mRNA localisation involved in pattern specification process http://purl.obolibrary.org/obo/GO_0060810 GO:0060811 biolink:BiologicalProcess intracellular mRNA localization involved in anterior/posterior axis specification Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis. go.json intracellular mRNA localisation involved in anterior/posterior axis specification http://purl.obolibrary.org/obo/GO_0060811 GO:0035800 biolink:MolecularActivity deubiquitinase activator activity Binds to and increases the activity of a deubiquitinase. go.json http://purl.obolibrary.org/obo/GO_0035800 GO:0060812 biolink:BiologicalProcess orthodenticle mRNA localization Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis. go.json orthodenticle mRNA localisation http://purl.obolibrary.org/obo/GO_0060812 GO:0060813 biolink:BiologicalProcess anterior mRNA localization involved in anterior/posterior axis specification Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis. go.json anterior mRNA localisation involved in anterior/posterior axis specification http://purl.obolibrary.org/obo/GO_0060813 GO:0060814 biolink:BiologicalProcess posterior mRNA localization involved in anterior/posterior axis specification Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis. go.json posterior mRNA localisation involved in anterior/posterior axis specification http://purl.obolibrary.org/obo/GO_0060814 GO:0060815 biolink:BiologicalProcess regulation of translation involved in anterior/posterior axis specification Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis. go.json http://purl.obolibrary.org/obo/GO_0060815 GO:0060816 biolink:BiologicalProcess random inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex. go.json rXCI http://purl.obolibrary.org/obo/GO_0060816 GO:0060817 biolink:BiologicalProcess obsolete inactivation of paternal X chromosome OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex. go.json True http://purl.obolibrary.org/obo/GO_0060817 GO:0060818 biolink:BiologicalProcess inactivation of paternal X chromosome by genomic imprinting Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genomic imprinting. go.json iXCI|inactivation of paternal X chromosome by genetic imprinting http://purl.obolibrary.org/obo/GO_0060818 GO:0060819 biolink:BiologicalProcess obsolete inactivation of X chromosome by genomic imprinting OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting. go.json inactivation of X chromosome by genetic imprinting True http://purl.obolibrary.org/obo/GO_0060819 GO:0060800 biolink:BiologicalProcess regulation of cell differentiation involved in embryonic placenta development Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. go.json http://purl.obolibrary.org/obo/GO_0060800 GO:0060801 biolink:BiologicalProcess obsolete negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway OBSOLETE. The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast. go.json negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway True http://purl.obolibrary.org/obo/GO_0060801 GO:0060802 biolink:BiologicalProcess epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis. go.json epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification http://purl.obolibrary.org/obo/GO_0060802 GO:0060803 biolink:BiologicalProcess obsolete BMP signaling pathway involved in mesodermal cell fate specification OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate. go.json BMP signalling pathway involved in mesodermal cell fate specification True http://purl.obolibrary.org/obo/GO_0060803 GO:0060804 biolink:BiologicalProcess obsolete positive regulation of Wnt signaling pathway by BMP signaling pathway OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway. go.json positive regulation of WNT receptor signaling pathway by BMP signaling pathway|positive regulation of WNT receptor signalling pathway by BMP signalling pathway|positive regulation of Wnt-activated signaling pathway by BMP signaling pathway True http://purl.obolibrary.org/obo/GO_0060804 GO:0060805 biolink:BiologicalProcess obsolete negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter OBSOLETE. Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast. go.json True http://purl.obolibrary.org/obo/GO_0060805 GO:0060806 biolink:BiologicalProcess negative regulation of cell differentiation involved in embryonic placenta development Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. go.json http://purl.obolibrary.org/obo/GO_0060806 GO:0060807 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate. go.json True http://purl.obolibrary.org/obo/GO_0060807 GO:0060808 biolink:BiologicalProcess positive regulation of mesodermal to mesenchymal transition involved in gastrulation Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0060808 GO:0060830 biolink:BiologicalProcess ciliary receptor clustering involved in smoothened signaling pathway Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway. go.json ciliary receptor clustering involved in hedgehog signaling pathway|ciliary receptor clustering involved in hh signaling pathway|ciliary receptor clustering involved in smoothened signalling pathway http://purl.obolibrary.org/obo/GO_0060830 GO:0060831 biolink:BiologicalProcess smoothened signaling pathway involved in dorsal/ventral neural tube patterning The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube. go.json hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|hh signaling pathway involved in dorsal/ventral neural tube patterning|smoothened signalling pathway involved in dorsal/ventral neural tube patterning http://purl.obolibrary.org/obo/GO_0060831 GO:0060832 biolink:BiologicalProcess oocyte animal/vegetal axis specification The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus. go.json http://purl.obolibrary.org/obo/GO_0060832 GO:0060833 biolink:BiologicalProcess Wnt signaling pathway involved in animal/vegetal axis specification The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte. go.json Wnt receptor signaling pathway involved in animal/vegetal axis specification|Wnt receptor signalling pathway involved in animal/vegetal axis specification|Wnt- activated signaling pathway involved in animal/vegetal axis specification http://purl.obolibrary.org/obo/GO_0060833 GO:0060834 biolink:BiologicalProcess oral/aboral axis specification The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo. go.json oral/aboral axis determination http://purl.obolibrary.org/obo/GO_0060834 GO:0060835 biolink:BiologicalProcess obsolete transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis. go.json transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification True http://purl.obolibrary.org/obo/GO_0060835 GO:0060836 biolink:BiologicalProcess lymphatic endothelial cell differentiation The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. go.json http://purl.obolibrary.org/obo/GO_0060836 GO:0060837 biolink:BiologicalProcess blood vessel endothelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. go.json http://purl.obolibrary.org/obo/GO_0060837 GO:0060838 biolink:BiologicalProcess lymphatic endothelial cell fate commitment The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0060838 GO:0060839 biolink:BiologicalProcess endothelial cell fate commitment The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0060839 GO:0045204 biolink:BiologicalProcess MAPK export from nucleus The directed movement of a MAP kinase from the nucleus to the cytoplasm. go.json MAPK export from cell nucleus|MAPK export out of nucleus|MAPK transport from nucleus to cytoplasm|MAPK-nucleus export|cytoplasmic translocation of MAP kinase|cytoplasmic translocation of mitogen-activated protein kinase http://purl.obolibrary.org/obo/GO_0045204 GO:0045205 biolink:MolecularActivity obsolete MAPK transporter activity OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells. go.json MAPK transporter activity True http://purl.obolibrary.org/obo/GO_0045205 GO:0045202 biolink:CellularComponent synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. NIF_Subcellular:sao914572699|Wikipedia:Chemical_synapse go.json electrotonic synapse|mixed synapse|synaptic junction http://purl.obolibrary.org/obo/GO_0045202 goslim_agr|goslim_drosophila|goslim_flybase_ribbon|goslim_mouse|goslim_pir|goslim_synapse GO:0045203 biolink:CellularComponent obsolete integral component of cell outer membrane OBSOLETE. The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to cell outer membrane|integral to external membrane|integral to outer membrane True http://purl.obolibrary.org/obo/GO_0045203 GO:0045200 biolink:BiologicalProcess establishment of neuroblast polarity The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. go.json establishment of neuroblast cell polarity http://purl.obolibrary.org/obo/GO_0045200 GO:0045201 biolink:BiologicalProcess maintenance of neuroblast polarity The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. go.json maintenance of neuroblast cell polarity http://purl.obolibrary.org/obo/GO_0045201 GO:0045208 biolink:BiologicalProcess MAPK phosphatase export from nucleus The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm. go.json MAPK phosphatase export from cell nucleus|MAPK phosphatase export out of nucleus|MAPK phosphatase transport from nucleus to cytoplasm|MAPK phosphatase-nucleus export http://purl.obolibrary.org/obo/GO_0045208 GO:0045209 biolink:BiologicalProcess MAPK phosphatase export from nucleus, leptomycin B sensitive Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm. go.json MAPK phosphatase export from cell nucleus, leptomycin B sensitive|MAPK phosphatase export out of nucleus, leptomycin B sensitive|MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive|MAPK phosphatase-nucleus export, leptomycin B sensitive|leptomycin B-sensitive MAPK phosphatase export out of nucleus|leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm|leptomycin B-sensitive MAPK phosphatase-nucleus export http://purl.obolibrary.org/obo/GO_0045209 GO:0060820 biolink:BiologicalProcess obsolete inactivation of X chromosome by heterochromatin formation OBSOLETE. Compensating for the two-fold variation in X-chromosome: autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation. go.json inactivation of X chromosome by heterochromatin assembly True http://purl.obolibrary.org/obo/GO_0060820 GO:0045206 biolink:MolecularActivity obsolete MAPK phosphatase transporter activity OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells. go.json MAPK phosphatase transporter activity|MKP shuttle|leptomycin B-sensitive MAPK phosphatase transporter activity|leptomycin B-sensitive MKP shuttle True http://purl.obolibrary.org/obo/GO_0045206 GO:0060821 biolink:BiologicalProcess obsolete inactivation of X chromosome by DNA methylation OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation. go.json True http://purl.obolibrary.org/obo/GO_0060821 GO:0060822 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate. go.json transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification True http://purl.obolibrary.org/obo/GO_0060822 GO:0045207 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045207 GO:0060823 biolink:BiologicalProcess canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern. go.json Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation|canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0060823 GO:0060824 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate. go.json retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0060824 GO:0060825 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate. go.json fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0060825 GO:0060826 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern. go.json transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation True http://purl.obolibrary.org/obo/GO_0060826 GO:0060827 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern. go.json regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation|regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation|regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0060827 GO:0060828 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json catenin import into nucleus|regulation of Wnt receptor signaling pathway through beta-catenin|regulation of canonical Wnt receptor signaling pathway|regulation of canonical Wnt receptor signalling pathway|regulation of canonical Wnt-activated signaling pathway|regulation of catenin import into nucleus|regulation of catenin protein nuclear translocation http://purl.obolibrary.org/obo/GO_0060828 GO:0060829 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis. go.json negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation|negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern|negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern http://purl.obolibrary.org/obo/GO_0060829 GO:1901707 biolink:MolecularActivity leptomycin B binding Binding to leptomycin B. go.json http://purl.obolibrary.org/obo/GO_1901707 GO:1901708 biolink:BiologicalProcess (+)-3'-hydroxylarreatricin biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-3'-hydroxylarreatricin. go.json (+)-3'-hydroxylarreatricin anabolism|(+)-3'-hydroxylarreatricin biosynthesis|(+)-3'-hydroxylarreatricin formation|(+)-3'-hydroxylarreatricin synthesis http://purl.obolibrary.org/obo/GO_1901708 GO:1901705 biolink:BiologicalProcess L-isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of L-isoleucine. go.json L-isoleucine anabolism|L-isoleucine biosynthesis|L-isoleucine formation|L-isoleucine synthesis http://purl.obolibrary.org/obo/GO_1901705 GO:1901706 biolink:BiologicalProcess mesenchymal cell differentiation involved in bone development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_1901706 GO:1901703 biolink:BiologicalProcess protein localization involved in auxin polar transport Any protein localization that is involved in auxin polar transport. go.json establishment and maintenance of protein localization involved in auxin polar transport|protein localisation involved in auxin polar transport http://purl.obolibrary.org/obo/GO_1901703 GO:1901704 biolink:BiologicalProcess L-glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of L-glutamine. go.json L-glutamine anabolism|L-glutamine biosynthesis|L-glutamine formation|L-glutamine synthesis http://purl.obolibrary.org/obo/GO_1901704 GO:1901701 biolink:BiologicalProcess cellular response to oxygen-containing compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. go.json cellular response to oxygen molecular entity http://purl.obolibrary.org/obo/GO_1901701 GO:1901702 biolink:MolecularActivity salt transmembrane transporter activity Enables the transfer of salt from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901702 GO:0045215 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045215 GO:1901700 biolink:BiologicalProcess response to oxygen-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. go.json response to oxygen molecular entity http://purl.obolibrary.org/obo/GO_1901700 GO:0045216 biolink:BiologicalProcess cell-cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. go.json cell-cell junction assembly and maintenance|cell-cell junction biogenesis|cell-cell junction organisation|intercellular junction assembly and maintenance http://purl.obolibrary.org/obo/GO_0045216 GO:0045213 biolink:BiologicalProcess obsolete neurotransmitter receptor metabolic process OBSOLETE. The chemical reactions and pathways involving neurotransmitter receptors. go.json neurotransmitter receptor metabolism True http://purl.obolibrary.org/obo/GO_0045213 GO:0045214 biolink:BiologicalProcess sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. go.json sarcomere alignment|sarcomere organisation http://purl.obolibrary.org/obo/GO_0045214 GO:0045211 biolink:CellularComponent postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. go.json post-synaptic membrane http://purl.obolibrary.org/obo/GO_0045211 goslim_synapse GO:0045212 biolink:BiologicalProcess obsolete neurotransmitter receptor biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitter receptors. go.json neurotransmitter receptor anabolism|neurotransmitter receptor biosynthesis|neurotransmitter receptor formation|neurotransmitter receptor synthesis True http://purl.obolibrary.org/obo/GO_0045212 GO:0045210 biolink:BiologicalProcess FasL biosynthetic process The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines. go.json APT1LG1 biosynthetic process|CD178 biosynthetic process|CD95L biosynthesis|CD95L biosynthetic process|FASLG biosynthetic process|Fas-L biosynthetic process|FasL anabolism|FasL biosynthesis|FasL formation|FasL synthesis|fas ligand biosynthetic process http://purl.obolibrary.org/obo/GO_0045210 GO:0060850 biolink:BiologicalProcess obsolete regulation of transcription involved in cell fate commitment OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. go.json True http://purl.obolibrary.org/obo/GO_0060850 GO:0060851 biolink:BiologicalProcess vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate. go.json vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment http://purl.obolibrary.org/obo/GO_0060851 GO:0045219 biolink:BiologicalProcess regulation of FasL production Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. go.json regulation of FasL anabolism|regulation of FasL biosynthesis|regulation of FasL formation|regulation of FasL synthesis http://purl.obolibrary.org/obo/GO_0045219 GO:0060852 biolink:BiologicalProcess obsolete regulation of transcription involved in venous endothelial cell fate commitment OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate. go.json True http://purl.obolibrary.org/obo/GO_0060852 GO:0060853 biolink:BiologicalProcess Notch signaling pathway involved in arterial endothelial cell fate commitment The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate. go.json Notch signalling pathway involved in arterial endothelial cell fate commitment http://purl.obolibrary.org/obo/GO_0060853 GO:0045217 biolink:BiologicalProcess cell-cell junction maintenance The maintenance of junctions between cells. go.json intercellular junction maintenance http://purl.obolibrary.org/obo/GO_0045217 GO:0060854 biolink:BiologicalProcess branching involved in lymph vessel morphogenesis The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system. go.json patterning of lymph vessels http://purl.obolibrary.org/obo/GO_0060854 GO:0045218 biolink:BiologicalProcess zonula adherens maintenance Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0045218 GO:0060855 biolink:BiologicalProcess venous endothelial cell migration involved in lymph vessel development The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells. go.json http://purl.obolibrary.org/obo/GO_0060855 GO:0060856 biolink:BiologicalProcess establishment of blood-brain barrier Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. go.json establishment of BBB|establishment of blood/brain barrier http://purl.obolibrary.org/obo/GO_0060856 GO:0060857 biolink:BiologicalProcess establishment of glial blood-brain barrier Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. go.json establishment of glial BBB|establishment of glial blood/brain barrier http://purl.obolibrary.org/obo/GO_0060857 GO:0060858 biolink:BiologicalProcess vesicle-mediated transport involved in floral organ abscission The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ. go.json membrane trafficking involved in floral organ shedding http://purl.obolibrary.org/obo/GO_0060858 GO:0060859 biolink:BiologicalProcess obsolete regulation of vesicle-mediated transport involved in floral organ abscission OBSOLETE. Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ. go.json True http://purl.obolibrary.org/obo/GO_0060859 GO:1901709 biolink:BiologicalProcess (+)-larreatricin metabolic process The chemical reactions and pathways involving (+)-larreatricin. go.json (+)-larreatricin metabolism http://purl.obolibrary.org/obo/GO_1901709 GO:1901718 biolink:BiologicalProcess obsolete regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of dipeptide transmembrane transport. go.json True http://purl.obolibrary.org/obo/GO_1901718 GO:1901719 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901719 GO:1901716 biolink:BiologicalProcess negative regulation of gamma-aminobutyric acid catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process. go.json down regulation of 4-aminobutanoate catabolic process|down regulation of 4-aminobutanoate catabolism|down regulation of 4-aminobutyrate catabolic process|down regulation of 4-aminobutyrate catabolism|down regulation of GABA catabolic process|down regulation of GABA catabolism|down regulation of gamma-aminobutyric acid breakdown|down regulation of gamma-aminobutyric acid catabolic process|down regulation of gamma-aminobutyric acid catabolism|down regulation of gamma-aminobutyric acid degradation|down-regulation of 4-aminobutanoate catabolic process|down-regulation of 4-aminobutanoate catabolism|down-regulation of 4-aminobutyrate catabolic process|down-regulation of 4-aminobutyrate catabolism|down-regulation of GABA catabolic process|down-regulation of GABA catabolism|down-regulation of gamma-aminobutyric acid breakdown|down-regulation of gamma-aminobutyric acid catabolic process|down-regulation of gamma-aminobutyric acid catabolism|down-regulation of gamma-aminobutyric acid degradation|downregulation of 4-aminobutanoate catabolic process|downregulation of 4-aminobutanoate catabolism|downregulation of 4-aminobutyrate catabolic process|downregulation of 4-aminobutyrate catabolism|downregulation of GABA catabolic process|downregulation of GABA catabolism|downregulation of gamma-aminobutyric acid breakdown|downregulation of gamma-aminobutyric acid catabolic process|downregulation of gamma-aminobutyric acid catabolism|downregulation of gamma-aminobutyric acid degradation|inhibition of 4-aminobutanoate catabolic process|inhibition of 4-aminobutanoate catabolism|inhibition of 4-aminobutyrate catabolic process|inhibition of 4-aminobutyrate catabolism|inhibition of GABA catabolic process|inhibition of GABA catabolism|inhibition of gamma-aminobutyric acid breakdown|inhibition of gamma-aminobutyric acid catabolic process|inhibition of gamma-aminobutyric acid catabolism|inhibition of gamma-aminobutyric acid degradation|negative regulation of 4-aminobutanoate catabolic process|negative regulation of 4-aminobutanoate catabolism|negative regulation of 4-aminobutyrate catabolic process|negative regulation of 4-aminobutyrate catabolism|negative regulation of GABA catabolic process|negative regulation of GABA catabolism|negative regulation of gamma-aminobutyric acid breakdown|negative regulation of gamma-aminobutyric acid catabolism|negative regulation of gamma-aminobutyric acid degradation http://purl.obolibrary.org/obo/GO_1901716 GO:1901717 biolink:BiologicalProcess positive regulation of gamma-aminobutyric acid catabolic process Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process. go.json activation of 4-aminobutanoate catabolic process|activation of 4-aminobutanoate catabolism|activation of 4-aminobutyrate catabolic process|activation of 4-aminobutyrate catabolism|activation of GABA catabolic process|activation of GABA catabolism|activation of gamma-aminobutyric acid breakdown|activation of gamma-aminobutyric acid catabolic process|activation of gamma-aminobutyric acid catabolism|activation of gamma-aminobutyric acid degradation|positive regulation of 4-aminobutanoate catabolic process|positive regulation of 4-aminobutanoate catabolism|positive regulation of 4-aminobutyrate catabolic process|positive regulation of 4-aminobutyrate catabolism|positive regulation of GABA catabolic process|positive regulation of GABA catabolism|positive regulation of gamma-aminobutyric acid breakdown|positive regulation of gamma-aminobutyric acid catabolism|positive regulation of gamma-aminobutyric acid degradation|up regulation of 4-aminobutanoate catabolic process|up regulation of 4-aminobutanoate catabolism|up regulation of 4-aminobutyrate catabolic process|up regulation of 4-aminobutyrate catabolism|up regulation of GABA catabolic process|up regulation of GABA catabolism|up regulation of gamma-aminobutyric acid breakdown|up regulation of gamma-aminobutyric acid catabolic process|up regulation of gamma-aminobutyric acid catabolism|up regulation of gamma-aminobutyric acid degradation|up-regulation of 4-aminobutanoate catabolic process|up-regulation of 4-aminobutanoate catabolism|up-regulation of 4-aminobutyrate catabolic process|up-regulation of 4-aminobutyrate catabolism|up-regulation of GABA catabolic process|up-regulation of GABA catabolism|up-regulation of gamma-aminobutyric acid breakdown|up-regulation of gamma-aminobutyric acid catabolic process|up-regulation of gamma-aminobutyric acid catabolism|up-regulation of gamma-aminobutyric acid degradation|upregulation of 4-aminobutanoate catabolic process|upregulation of 4-aminobutanoate catabolism|upregulation of 4-aminobutyrate catabolic process|upregulation of 4-aminobutyrate catabolism|upregulation of GABA catabolic process|upregulation of GABA catabolism|upregulation of gamma-aminobutyric acid breakdown|upregulation of gamma-aminobutyric acid catabolic process|upregulation of gamma-aminobutyric acid catabolism|upregulation of gamma-aminobutyric acid degradation http://purl.obolibrary.org/obo/GO_1901717 GO:1901714 biolink:BiologicalProcess positive regulation of urea catabolic process Any process that activates or increases the frequency, rate or extent of urea catabolic process. go.json activation of urea breakdown|activation of urea catabolic process|activation of urea catabolism|activation of urea decomposition|activation of urea degradation|positive regulation of urea breakdown|positive regulation of urea catabolism|positive regulation of urea decomposition|positive regulation of urea degradation|up regulation of urea breakdown|up regulation of urea catabolic process|up regulation of urea catabolism|up regulation of urea decomposition|up regulation of urea degradation|up-regulation of urea breakdown|up-regulation of urea catabolic process|up-regulation of urea catabolism|up-regulation of urea decomposition|up-regulation of urea degradation|upregulation of urea breakdown|upregulation of urea catabolic process|upregulation of urea catabolism|upregulation of urea decomposition|upregulation of urea degradation http://purl.obolibrary.org/obo/GO_1901714 GO:1901715 biolink:BiologicalProcess regulation of gamma-aminobutyric acid catabolic process Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process. go.json regulation of 4-aminobutanoate catabolic process|regulation of 4-aminobutanoate catabolism|regulation of 4-aminobutyrate catabolic process|regulation of 4-aminobutyrate catabolism|regulation of GABA catabolic process|regulation of GABA catabolism|regulation of gamma-aminobutyric acid breakdown|regulation of gamma-aminobutyric acid catabolism|regulation of gamma-aminobutyric acid degradation http://purl.obolibrary.org/obo/GO_1901715 GO:1901712 biolink:BiologicalProcess positive regulation of homoserine biosynthetic process Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process. go.json activation of homoserine anabolism|activation of homoserine biosynthesis|activation of homoserine biosynthetic process|activation of homoserine formation|activation of homoserine synthesis|positive regulation of homoserine anabolism|positive regulation of homoserine biosynthesis|positive regulation of homoserine formation|positive regulation of homoserine synthesis|up regulation of homoserine anabolism|up regulation of homoserine biosynthesis|up regulation of homoserine biosynthetic process|up regulation of homoserine formation|up regulation of homoserine synthesis|up-regulation of homoserine anabolism|up-regulation of homoserine biosynthesis|up-regulation of homoserine biosynthetic process|up-regulation of homoserine formation|up-regulation of homoserine synthesis|upregulation of homoserine anabolism|upregulation of homoserine biosynthesis|upregulation of homoserine biosynthetic process|upregulation of homoserine formation|upregulation of homoserine synthesis http://purl.obolibrary.org/obo/GO_1901712 GO:1901713 biolink:BiologicalProcess negative regulation of urea catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process. go.json down regulation of urea breakdown|down regulation of urea catabolic process|down regulation of urea catabolism|down regulation of urea decomposition|down regulation of urea degradation|down-regulation of urea breakdown|down-regulation of urea catabolic process|down-regulation of urea catabolism|down-regulation of urea decomposition|down-regulation of urea degradation|downregulation of urea breakdown|downregulation of urea catabolic process|downregulation of urea catabolism|downregulation of urea decomposition|downregulation of urea degradation|inhibition of urea breakdown|inhibition of urea catabolic process|inhibition of urea catabolism|inhibition of urea decomposition|inhibition of urea degradation|negative regulation of urea breakdown|negative regulation of urea catabolism|negative regulation of urea decomposition|negative regulation of urea degradation http://purl.obolibrary.org/obo/GO_1901713 GO:1901710 biolink:BiologicalProcess regulation of homoserine biosynthetic process Any process that modulates the frequency, rate or extent of homoserine biosynthetic process. go.json regulation of homoserine anabolism|regulation of homoserine biosynthesis|regulation of homoserine formation|regulation of homoserine synthesis http://purl.obolibrary.org/obo/GO_1901710 GO:0045226 biolink:BiologicalProcess extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. go.json extracellular polysaccharide anabolism|extracellular polysaccharide biosynthesis|extracellular polysaccharide formation|extracellular polysaccharide synthesis http://purl.obolibrary.org/obo/GO_0045226 GO:1901711 biolink:BiologicalProcess negative regulation of homoserine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process. go.json down regulation of homoserine anabolism|down regulation of homoserine biosynthesis|down regulation of homoserine biosynthetic process|down regulation of homoserine formation|down regulation of homoserine synthesis|down-regulation of homoserine anabolism|down-regulation of homoserine biosynthesis|down-regulation of homoserine biosynthetic process|down-regulation of homoserine formation|down-regulation of homoserine synthesis|downregulation of homoserine anabolism|downregulation of homoserine biosynthesis|downregulation of homoserine biosynthetic process|downregulation of homoserine formation|downregulation of homoserine synthesis|inhibition of homoserine anabolism|inhibition of homoserine biosynthesis|inhibition of homoserine biosynthetic process|inhibition of homoserine formation|inhibition of homoserine synthesis|negative regulation of homoserine anabolism|negative regulation of homoserine biosynthesis|negative regulation of homoserine formation|negative regulation of homoserine synthesis http://purl.obolibrary.org/obo/GO_1901711 GO:0045227 biolink:BiologicalProcess capsule polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. go.json capsular polysaccharide biosynthesis|capsular polysaccharide biosynthetic process|capsule polysaccharide anabolism|capsule polysaccharide biosynthesis|capsule polysaccharide formation|capsule polysaccharide synthesis http://purl.obolibrary.org/obo/GO_0045227 GO:0045224 biolink:BiologicalProcess positive regulation of CD4 production Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. go.json activation of CD4 biosynthetic process|positive regulation of CD4 anabolism|positive regulation of CD4 biosynthesis|positive regulation of CD4 biosynthetic process|positive regulation of CD4 formation|positive regulation of CD4 synthesis|stimulation of CD4 biosynthetic process|up regulation of CD4 biosynthetic process|up-regulation of CD4 biosynthetic process|upregulation of CD4 biosynthetic process http://purl.obolibrary.org/obo/GO_0045224 GO:0045225 biolink:BiologicalProcess negative regulation of CD4 production Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. go.json down regulation of CD4 biosynthetic process|down-regulation of CD4 biosynthetic process|downregulation of CD4 biosynthetic process|inhibition of CD4 biosynthetic process|negative regulation of CD4 anabolism|negative regulation of CD4 biosynthesis|negative regulation of CD4 biosynthetic process|negative regulation of CD4 formation|negative regulation of CD4 synthesis http://purl.obolibrary.org/obo/GO_0045225 GO:0045222 biolink:BiologicalProcess CD4 biosynthetic process The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. go.json CD4 anabolism|CD4 biosynthesis|CD4 formation|CD4 synthesis http://purl.obolibrary.org/obo/GO_0045222 GO:0045223 biolink:BiologicalProcess regulation of CD4 production Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. go.json regulation of CD4 anabolism|regulation of CD4 biosynthesis|regulation of CD4 biosynthetic process|regulation of CD4 formation|regulation of CD4 synthesis http://purl.obolibrary.org/obo/GO_0045223 GO:0045220 biolink:BiologicalProcess positive regulation of FasL production Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. go.json activation of FasL biosynthetic process|positive regulation of FasL anabolism|positive regulation of FasL biosynthesis|positive regulation of FasL biosynthetic process|positive regulation of FasL formation|positive regulation of FasL synthesis|stimulation of FasL biosynthetic process|up regulation of FasL biosynthetic process|up-regulation of FasL biosynthetic process|upregulation of FasL biosynthetic process http://purl.obolibrary.org/obo/GO_0045220 GO:0045221 biolink:BiologicalProcess negative regulation of FasL production Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. go.json down regulation of FasL biosynthetic process|down-regulation of FasL biosynthetic process|downregulation of FasL biosynthetic process|inhibition of FasL biosynthetic process|negative regulation of FasL anabolism|negative regulation of FasL biosynthesis|negative regulation of FasL biosynthetic process|negative regulation of FasL formation|negative regulation of FasL synthesis http://purl.obolibrary.org/obo/GO_0045221 GO:0060840 biolink:BiologicalProcess artery development The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. go.json http://purl.obolibrary.org/obo/GO_0060840 GO:0060841 biolink:BiologicalProcess venous blood vessel development The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. go.json http://purl.obolibrary.org/obo/GO_0060841 GO:0060842 biolink:BiologicalProcess arterial endothelial cell differentiation The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. go.json http://purl.obolibrary.org/obo/GO_0060842 GO:0060843 biolink:BiologicalProcess venous endothelial cell differentiation The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. go.json http://purl.obolibrary.org/obo/GO_0060843 GO:0045228 biolink:BiologicalProcess slime layer polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall. go.json slime layer polysaccharide anabolism|slime layer polysaccharide biosynthesis|slime layer polysaccharide formation|slime layer polysaccharide synthesis http://purl.obolibrary.org/obo/GO_0045228 GO:0045229 biolink:BiologicalProcess external encapsulating structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. go.json external encapsulating structure organisation|external encapsulating structure organization and biogenesis http://purl.obolibrary.org/obo/GO_0045229 goslim_pir GO:0060844 biolink:BiologicalProcess arterial endothelial cell fate commitment The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0060844 GO:0060845 biolink:BiologicalProcess venous endothelial cell fate commitment The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0060845 GO:0060846 biolink:BiologicalProcess blood vessel endothelial cell fate commitment The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0060846 GO:0060847 biolink:BiologicalProcess endothelial cell fate specification The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. go.json http://purl.obolibrary.org/obo/GO_0060847 GO:0060848 biolink:BiologicalProcess endothelial cell fate determination A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. go.json http://purl.obolibrary.org/obo/GO_0060848 GO:0060849 biolink:BiologicalProcess obsolete regulation of transcription involved in lymphatic endothelial cell fate commitment OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell. go.json True http://purl.obolibrary.org/obo/GO_0060849 GO:0035892 biolink:BiologicalProcess perturbation of platelet aggregation in another organism The process in which an organism effects a change that affects platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. go.json modulation by organism of platelet aggregation in other organism|modulation of platelet aggregation in another organism|modulation of platelet aggregation in other organism|regulation of platelet aggregation in other organism http://purl.obolibrary.org/obo/GO_0035892 GO:0035893 biolink:BiologicalProcess suppression of platelet aggregation in another organism Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism. go.json disruption of platelet aggregation in other organism|down-regulation of platelet aggregation in other organism|downregulation of platelet aggregation in other organism|inhibition of platelet aggregation in other organism|negative regulation of platelet aggregation in another organism|negative regulation of platelet aggregation in other organism http://purl.obolibrary.org/obo/GO_0035893 GO:0035894 biolink:BiologicalProcess induction of platelet aggregation in another organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism. go.json positive regulation of platelet aggregation in another organism|positive regulation of platelet aggregation in other organism|up-regulation of platelet aggregation in other organism|upregulation of platelet aggregation in other organism http://purl.obolibrary.org/obo/GO_0035894 GO:0035895 biolink:BiologicalProcess modulation of mast cell degranulation in another organism Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. go.json modulation of mast cell degranulation in other organism|regulation of mast cell degranulation in other organism http://purl.obolibrary.org/obo/GO_0035895 GO:0035896 biolink:BiologicalProcess positive regulation of mast cell degranulation in another organism Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism. go.json positive regulation of mast cell degranulation in other organism|up-regulation of mast cell degranulation in other organism|upregulation of mast cell degranulation in other organism http://purl.obolibrary.org/obo/GO_0035896 GO:0035897 biolink:BiologicalProcess obsolete proteolysis in other organism OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds. go.json True http://purl.obolibrary.org/obo/GO_0035897 GO:0035898 biolink:BiologicalProcess parathyroid hormone secretion The regulated release of parathyroid hormone into the circulatory system. go.json PTH secretion|parathormone secretion|parathyrin secretion http://purl.obolibrary.org/obo/GO_0035898 GO:0035899 biolink:BiologicalProcess suppression of blood coagulation in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. go.json disruption of blood coagulation in other organism|down-regulation of blood coagulation in other organism|downregulation of blood coagulation in other organism|inhibition of blood coagulation in other organism|negative regulation of blood clotting in other organism|negative regulation of blood coagulation in another organism|negative regulation of blood coagulation in other organism|suppression of blood clotting in another organism http://purl.obolibrary.org/obo/GO_0035899 GO:0035890 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035890 GO:0035891 biolink:BiologicalProcess exit from host cell The movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json ejection from host|ejection from host cell|exit from host|host cell exit http://purl.obolibrary.org/obo/GO_0035891 GO:0035889 biolink:BiologicalProcess otolith tethering The attachment of a developing otolith to the kinocilia of tether cells in the inner ear. go.json http://purl.obolibrary.org/obo/GO_0035889 GO:0035881 biolink:BiologicalProcess amacrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons. go.json amacrine neuron differentiation http://purl.obolibrary.org/obo/GO_0035881 GO:0035882 biolink:BiologicalProcess defecation rhythm The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated. go.json DMP|defecation behavior|defecation cycle|defecation motor program http://purl.obolibrary.org/obo/GO_0035882 GO:0035883 biolink:BiologicalProcess enteroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. go.json http://purl.obolibrary.org/obo/GO_0035883 GO:0035884 biolink:BiologicalProcess arabinan biosynthetic process The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues. go.json http://purl.obolibrary.org/obo/GO_0035884 GO:0035885 biolink:MolecularActivity exochitinase activity Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain. MetaCyc:RXN-12309|RHEA:50672 go.json http://purl.obolibrary.org/obo/GO_0035885 GO:0035886 biolink:BiologicalProcess vascular associated smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. go.json VSMC differentiation|vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_0035886 GO:0035887 biolink:BiologicalProcess aortic smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. go.json http://purl.obolibrary.org/obo/GO_0035887 GO:0035888 biolink:MolecularActivity isoguanine deaminase activity Catalysis of the reaction: isoguanine + H2O = xanthine + NH3. go.json 2-hydroxyadenine deaminase activity|2-oxoadenine deaminase activity http://purl.obolibrary.org/obo/GO_0035888 GO:0035880 biolink:BiologicalProcess embryonic nail plate morphogenesis The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits. go.json http://purl.obolibrary.org/obo/GO_0035880 GO:0035878 biolink:BiologicalProcess nail development The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. go.json http://purl.obolibrary.org/obo/GO_0035878 GO:0035879 biolink:BiologicalProcess plasma membrane lactate transport The directed movement of lactate across a plasma membrane. go.json lactate plasma membrane transport http://purl.obolibrary.org/obo/GO_0035879 GO:0035870 biolink:MolecularActivity dITP diphosphatase activity Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate. EC:3.6.1.66|KEGG_REACTION:R03531|MetaCyc:RXN0-1602|RHEA:28342|Reactome:R-HSA-2509838 go.json 2'-deoxyinosine-5'-triphosphate pyrophosphohydrolase activity|dITP pyrophosphatase activity|deoxyinosine triphosphate pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0035870 GO:0035871 biolink:BiologicalProcess protein K11-linked deubiquitination A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. go.json protein K11-linked deubiquitinylation|protein K11-linked deubiquitylation http://purl.obolibrary.org/obo/GO_0035871 gocheck_do_not_annotate GO:0035872 biolink:BiologicalProcess nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. go.json NLR signaling pathway|NOD-like receptor signaling pathway|nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signal transduction|nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway|nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway http://purl.obolibrary.org/obo/GO_0035872 GO:0035873 biolink:BiologicalProcess lactate transmembrane transport The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. go.json lactate membrane transport http://purl.obolibrary.org/obo/GO_0035873 GO:0035874 biolink:BiologicalProcess cellular response to copper ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions. go.json cellular response to copper starvation http://purl.obolibrary.org/obo/GO_0035874 GO:0035875 biolink:BiologicalProcess maintenance of meiotic sister chromatid cohesion, centromeric The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. go.json maintenance of centromeric meiotic sister chromatin cohesion|maintenance of meiotic sister chromatin cohesion at centromere|maintenance of sister chromatin cohesion at centromere at meiosis I http://purl.obolibrary.org/obo/GO_0035875 GO:0035876 biolink:BiologicalProcess obsolete maintenance of meiotic sister chromatid cohesion, arms OBSOLETE. The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. go.json maintenance of meiotic sister chromatin cohesion along arms|maintenance of sister chromatin cohesion along arms at meiosis I True http://purl.obolibrary.org/obo/GO_0035876 GO:0035877 biolink:MolecularActivity death effector domain binding Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD). go.json DED binding http://purl.obolibrary.org/obo/GO_0035877 GO:0035867 biolink:CellularComponent alphav-beta3 integrin-IGF-1-IGF1R complex A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits. go.json http://purl.obolibrary.org/obo/GO_0035867 GO:0035868 biolink:CellularComponent alphav-beta3 integrin-HMGB1 complex A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein. go.json alphav-beta3 integrin-high mobility group box 1 complex http://purl.obolibrary.org/obo/GO_0035868 GO:0035869 biolink:CellularComponent ciliary transition zone A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. go.json cilial transition zone|cilium transition zone|connecting cilium http://purl.obolibrary.org/obo/GO_0035869 GO:0035860 biolink:BiologicalProcess glial cell-derived neurotrophic factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor. go.json GDNF receptor signaling pathway|glial cell derived neurotrophic factor receptor signaling pathway|glial cell line-derived neurotrophic factor receptor signalling pathway|glial cell-derived neurotrophic factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0035860 GO:0035861 biolink:CellularComponent site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. go.json DNA damage foci|DNA damage focus|IRIF|ionizing radiation-induced foci|site of DSB http://purl.obolibrary.org/obo/GO_0035861 GO:0035862 biolink:BiologicalProcess dITP metabolic process The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position. go.json 2'-Deoxyinosine 5'-triphosphate metabolic process|2'-Deoxyinosine-5'-triphosphate metabolic process|dITP metabolism|deoxyinosine 5'-triphosphate metabolic process|deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process http://purl.obolibrary.org/obo/GO_0035862 GO:0035863 biolink:BiologicalProcess dITP catabolic process The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position. go.json 2'-Deoxyinosine 5'-triphosphate catabolic process|2'-Deoxyinosine-5'-triphosphate catabolic process|dITP breakdown|dITP catabolism|dITP degradation|deoxyinosine 5'-triphosphate catabolic process|deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process http://purl.obolibrary.org/obo/GO_0035863 GO:0035864 biolink:BiologicalProcess response to potassium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. go.json response to K+ ion|response to potassium http://purl.obolibrary.org/obo/GO_0035864 GO:0035865 biolink:BiologicalProcess cellular response to potassium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. go.json cellular response to K+ ion|cellular response to potassium http://purl.obolibrary.org/obo/GO_0035865 GO:0035866 biolink:CellularComponent alphav-beta3 integrin-PKCalpha complex A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha. go.json alphav-beta3 integrin-PKCa complex|alphav-beta3 integrin-protein kinase C alpha complex http://purl.obolibrary.org/obo/GO_0035866 GO:0035856 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035856 GO:0035857 biolink:BiologicalProcess eosinophil fate specification The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. go.json eosinophil cell fate specification http://purl.obolibrary.org/obo/GO_0035857 GO:0035858 biolink:BiologicalProcess eosinophil fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json eosinophil cell fate determination http://purl.obolibrary.org/obo/GO_0035858 GO:0035859 biolink:CellularComponent Seh1-associated complex A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p. go.json GATOR complex|SEA complex http://purl.obolibrary.org/obo/GO_0035859 GO:0035850 biolink:BiologicalProcess epithelial cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0035850 GO:0035851 biolink:MolecularActivity Krueppel-associated box domain binding Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. go.json KRAB domain binding|Krueppel-associated box binding http://purl.obolibrary.org/obo/GO_0035851 GO:0035852 biolink:BiologicalProcess horizontal cell localization Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina. go.json horizontal cell localisation|horizontal cell positioning|laminar positioning of retinal horizontal cell|retinal horizontal cell positioning http://purl.obolibrary.org/obo/GO_0035852 GO:0035853 biolink:BiologicalProcess chromosome passenger complex localization to spindle midzone A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. go.json CPC complex localization to spindle midzone|CPC localization to spindle midzone|chromosomal passenger complex localization to spindle midzone|chromosome passenger complex localisation to spindle midzone|chromosome passenger complex localization to central spindle|chromosome passenger complex localization to spindle equator http://purl.obolibrary.org/obo/GO_0035853 GO:0035854 biolink:BiologicalProcess eosinophil fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. go.json eosinophil cell fate commitment http://purl.obolibrary.org/obo/GO_0035854 GO:0035855 biolink:BiologicalProcess megakaryocyte development The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. go.json megakaryocyte cell development http://purl.obolibrary.org/obo/GO_0035855 GO:0035845 biolink:BiologicalProcess photoreceptor cell outer segment organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials. go.json photoreceptor cell outer segment organisation|photoreceptor outer segment organization http://purl.obolibrary.org/obo/GO_0035845 GO:0035846 biolink:BiologicalProcess oviduct epithelium development The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct. go.json fallopian tube epithelium development http://purl.obolibrary.org/obo/GO_0035846 GO:0035847 biolink:BiologicalProcess uterine epithelium development The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. go.json uterus epithelial development http://purl.obolibrary.org/obo/GO_0035847 GO:0035848 biolink:BiologicalProcess oviduct morphogenesis The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. go.json fallopian tube morphogenesis http://purl.obolibrary.org/obo/GO_0035848 GO:0035849 biolink:BiologicalProcess nephric duct elongation The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney. go.json http://purl.obolibrary.org/obo/GO_0035849 GO:0035840 biolink:CellularComponent old growing cell tip A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures. go.json old growing cell end http://purl.obolibrary.org/obo/GO_0035840 GO:0035841 biolink:CellularComponent new growing cell tip A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth. go.json new cell tip after activation of bipolar cell growth|post-NETO new cell end|post-NETO new cell tip|post-new end take-off new cell tip http://purl.obolibrary.org/obo/GO_0035841 GO:0035842 biolink:CellularComponent old cell tip after activation of bipolar cell growth A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures. go.json post-NETO old cell end|post-NETO old cell tip|post-new end take-off old cell tip http://purl.obolibrary.org/obo/GO_0035842 GO:0035843 biolink:CellularComponent endonuclear canal A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope. go.json http://purl.obolibrary.org/obo/GO_0035843 GO:0035844 biolink:BiologicalProcess cloaca development The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. go.json cloacal development http://purl.obolibrary.org/obo/GO_0035844 GO:0035834 biolink:BiologicalProcess indole alkaloid metabolic process The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton. go.json indole alkaloid metabolism http://purl.obolibrary.org/obo/GO_0035834 GO:0035835 biolink:BiologicalProcess indole alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton. go.json indole alkaloid anabolism|indole alkaloid biosynthesis|indole alkaloid formation|indole alkaloid synthesis http://purl.obolibrary.org/obo/GO_0035835 GO:0035836 biolink:BiologicalProcess ergot alkaloid metabolic process The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid. go.json ergot alkaloid metabolism http://purl.obolibrary.org/obo/GO_0035836 GO:0035837 biolink:BiologicalProcess ergot alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of an ergot alkaloid. go.json ergot alkaloid anabolism|ergot alkaloid biosynthesis|ergot alkaloid formation|ergot alkaloid synthesis http://purl.obolibrary.org/obo/GO_0035837 GO:0035838 biolink:CellularComponent growing cell tip The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs. go.json growing cell end http://purl.obolibrary.org/obo/GO_0035838 GO:0035839 biolink:CellularComponent non-growing cell tip A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures. go.json new cell end|non-growing cell end http://purl.obolibrary.org/obo/GO_0035839 GO:0035830 biolink:BiologicalProcess palmatine metabolic process The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants. go.json palmatine metabolism http://purl.obolibrary.org/obo/GO_0035830 GO:0035831 biolink:BiologicalProcess palmatine biosynthetic process The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants. go.json palmatine anabolism|palmatine biosynthesis|palmatine formation|palmatine synthesis http://purl.obolibrary.org/obo/GO_0035831 GO:0035832 biolink:BiologicalProcess berbamunine metabolic process The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid. go.json berbamunine metabolism http://purl.obolibrary.org/obo/GO_0035832 GO:0035833 biolink:BiologicalProcess berbamunine biosynthetic process The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid. go.json berbamunine anabolism|berbamunine biosynthesis|berbamunine formation|berbamunine synthesis http://purl.obolibrary.org/obo/GO_0035833 GO:0045196 biolink:BiologicalProcess establishment or maintenance of neuroblast polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. go.json establishment and/or maintenance of neuroblast cell polarity http://purl.obolibrary.org/obo/GO_0045196 GO:0070152 biolink:BiologicalProcess mitochondrial isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070152 GO:0045197 biolink:BiologicalProcess establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0045197 GO:0070153 biolink:BiologicalProcess mitochondrial leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070153 GO:0045194 biolink:BiologicalProcess obsolete oxidized low-density lipoprotein catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins. go.json Ox-LDL catabolic process|Ox-LDL catabolism|oxidized low-density lipoprotein breakdown|oxidized low-density lipoprotein catabolic process|oxidized low-density lipoprotein catabolism|oxidized low-density lipoprotein degradation True http://purl.obolibrary.org/obo/GO_0045194 GO:0070150 biolink:BiologicalProcess mitochondrial glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070150 GO:0045195 biolink:BiologicalProcess obsolete gallstone formation OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile. go.json gallstone formation True http://purl.obolibrary.org/obo/GO_0045195 GO:0070151 biolink:BiologicalProcess mitochondrial histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070151 GO:0045192 biolink:BiologicalProcess obsolete low-density lipoprotein catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats. go.json LDL catabolic process|LDL catabolism|low-density lipoprotein breakdown|low-density lipoprotein catabolic process|low-density lipoprotein catabolism|low-density lipoprotein degradation True http://purl.obolibrary.org/obo/GO_0045192 GO:0045193 biolink:BiologicalProcess obsolete acetylated low-density lipoprotein catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins. go.json Ac-LDL catabolic process|Ac-LDL catabolism|acetylated low-density lipoprotein breakdown|acetylated low-density lipoprotein catabolic process|acetylated low-density lipoprotein catabolism|acetylated low-density lipoprotein degradation True http://purl.obolibrary.org/obo/GO_0045193 GO:0045190 biolink:BiologicalProcess isotype switching The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. Wikipedia:Immunoglobulin_class_switching go.json class switch recombination|class switching|isotype switch recombination http://purl.obolibrary.org/obo/GO_0045190 GO:0045191 biolink:BiologicalProcess regulation of isotype switching Any process that modulates the frequency, rate or extent of isotype switching. go.json regulation of class switch recombination|regulation of class switching|regulation of isotype switch recombination http://purl.obolibrary.org/obo/GO_0045191 GO:1901688 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901688 GO:1901689 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901689 GO:1901686 biolink:BiologicalProcess glutathione derivative catabolic process The chemical reactions and pathways resulting in the breakdown of glutathione derivative. go.json glutathione derivative breakdown|glutathione derivative catabolism|glutathione derivative degradation http://purl.obolibrary.org/obo/GO_1901686 GO:1901687 biolink:BiologicalProcess glutathione derivative biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione derivative. go.json glutathione derivative anabolism|glutathione derivative biosynthesis|glutathione derivative formation|glutathione derivative synthesis http://purl.obolibrary.org/obo/GO_1901687 GO:1901684 biolink:BiologicalProcess arsenate ion transmembrane transport The process in which arsenate is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1901684 GO:1901685 biolink:BiologicalProcess glutathione derivative metabolic process The chemical reactions and pathways involving glutathione derivative. go.json glutathione derivative metabolism http://purl.obolibrary.org/obo/GO_1901685 GO:0045198 biolink:BiologicalProcess establishment of epithelial cell apical/basal polarity The specification and formation of the apicobasal polarity of an epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0045198 GO:1901682 biolink:MolecularActivity sulfur compound transmembrane transporter activity Enables the transfer of a sulfur compound from one side of a membrane to the other. go.json sulfur molecular entity transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901682 GO:1901683 biolink:MolecularActivity arsenate ion transmembrane transporter activity Enables the transfer of an arsenate ion from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901683 GO:0045199 biolink:BiologicalProcess maintenance of epithelial cell apical/basal polarity The maintenance of the apicobasal polarity of an epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0045199 GO:1901691 biolink:MolecularActivity proton binding Binding to proton. go.json hydrogen ion binding http://purl.obolibrary.org/obo/GO_1901691 GO:1901692 biolink:BiologicalProcess regulation of compound eye retinal cell apoptotic process Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. go.json http://purl.obolibrary.org/obo/GO_1901692 GO:1901690 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901690 GO:0070158 biolink:BiologicalProcess mitochondrial seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070158 GO:0070159 biolink:BiologicalProcess mitochondrial threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070159 GO:0070156 biolink:BiologicalProcess mitochondrial phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070156 GO:0070157 biolink:BiologicalProcess mitochondrial prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070157 GO:0070154 biolink:BiologicalProcess mitochondrial lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070154 GO:0070155 biolink:BiologicalProcess mitochondrial methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070155 GO:0070141 biolink:BiologicalProcess response to UV-A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. go.json response to UV-A light stimulus|response to UV-A radiation stimulus|response to UVA light stimulus|response to UVA radiation stimulus http://purl.obolibrary.org/obo/GO_0070141 GO:0070142 biolink:BiologicalProcess synaptic vesicle budding Evagination of a membrane to form a synaptic vesicle. go.json http://purl.obolibrary.org/obo/GO_0070142 GO:0070140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070140 GO:1901699 biolink:BiologicalProcess cellular response to nitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. go.json cellular response to nitrogen molecular entity http://purl.obolibrary.org/obo/GO_1901699 GO:1901697 biolink:BiologicalProcess olivetolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of olivetolic acid. go.json olivetolic acid anabolism|olivetolic acid biosynthesis|olivetolic acid formation|olivetolic acid synthesis http://purl.obolibrary.org/obo/GO_1901697 GO:1901698 biolink:BiologicalProcess response to nitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. go.json response to nitrogen molecular entity http://purl.obolibrary.org/obo/GO_1901698 GO:1901695 biolink:BiologicalProcess tyramine biosynthetic process The chemical reactions and pathways resulting in the formation of tyramine. go.json tyramine anabolism|tyramine biosynthesis|tyramine formation|tyramine synthesis http://purl.obolibrary.org/obo/GO_1901695 GO:1901696 biolink:BiologicalProcess cannabinoid biosynthetic process The chemical reactions and pathways resulting in the formation of cannabinoid. go.json cannabinoid anabolism|cannabinoid biosynthesis|cannabinoid formation|cannabinoid synthesis http://purl.obolibrary.org/obo/GO_1901696 GO:1901693 biolink:BiologicalProcess negative regulation of compound eye retinal cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. go.json down regulation of compound eye retinal cell apoptotic process|down-regulation of compound eye retinal cell apoptotic process|downregulation of compound eye retinal cell apoptotic process|inhibition of compound eye retinal cell apoptotic process http://purl.obolibrary.org/obo/GO_1901693 GO:1901694 biolink:BiologicalProcess positive regulation of compound eye retinal cell apoptotic process Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. go.json activation of compound eye retinal cell apoptotic process|induction of compound eye retinal cell programmed cell death|up regulation of compound eye retinal cell apoptotic process|up-regulation of compound eye retinal cell apoptotic process|upregulation of compound eye retinal cell apoptotic process http://purl.obolibrary.org/obo/GO_1901694 GO:0070149 biolink:BiologicalProcess mitochondrial glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070149 GO:0070147 biolink:BiologicalProcess mitochondrial cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070147 GO:0070148 biolink:BiologicalProcess mitochondrial glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070148 GO:0070145 biolink:BiologicalProcess mitochondrial asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070145 GO:0070146 biolink:BiologicalProcess mitochondrial aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070146 GO:0070143 biolink:BiologicalProcess mitochondrial alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070143 GO:0070144 biolink:BiologicalProcess mitochondrial arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070144 GO:0070174 biolink:BiologicalProcess negative regulation of enamel mineralization Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. go.json http://purl.obolibrary.org/obo/GO_0070174 GO:0070175 biolink:BiologicalProcess positive regulation of enamel mineralization Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. go.json http://purl.obolibrary.org/obo/GO_0070175 GO:0070172 biolink:BiologicalProcess positive regulation of tooth mineralization Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. go.json http://purl.obolibrary.org/obo/GO_0070172 GO:0070173 biolink:BiologicalProcess regulation of enamel mineralization Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. go.json http://purl.obolibrary.org/obo/GO_0070173 GO:0070170 biolink:BiologicalProcess regulation of tooth mineralization Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. go.json http://purl.obolibrary.org/obo/GO_0070170 GO:0070171 biolink:BiologicalProcess negative regulation of tooth mineralization Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. go.json http://purl.obolibrary.org/obo/GO_0070171 GO:0070178 biolink:BiologicalProcess D-serine metabolic process The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. go.json D-serine metabolism http://purl.obolibrary.org/obo/GO_0070178 GO:0070179 biolink:BiologicalProcess D-serine biosynthetic process The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine. go.json D-serine anabolism|D-serine biosynthesis|D-serine formation|D-serine synthesis http://purl.obolibrary.org/obo/GO_0070179 GO:0070176 biolink:CellularComponent DRM complex A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification. go.json DP/Rb/MuvB http://purl.obolibrary.org/obo/GO_0070176 GO:0070177 biolink:BiologicalProcess contractile vacuole discharge The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0070177 GO:0070163 biolink:BiologicalProcess regulation of adiponectin secretion Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell. go.json http://purl.obolibrary.org/obo/GO_0070163 GO:0070164 biolink:BiologicalProcess negative regulation of adiponectin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell. go.json down regulation of adiponectin secretion|down-regulation of adiponectin secretion|downregulation of adiponectin secretion|inhibition of adiponectin secretion http://purl.obolibrary.org/obo/GO_0070164 GO:0070161 biolink:CellularComponent anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. go.json anchoring cell junction http://purl.obolibrary.org/obo/GO_0070161 GO:0070162 biolink:BiologicalProcess adiponectin secretion The regulated release of adiponectin, a protein hormone, by adipose tissue. go.json http://purl.obolibrary.org/obo/GO_0070162 GO:0070160 biolink:CellularComponent tight junction A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. Wikipedia:Tight_junction go.json occluding cell junction|occluding junction http://purl.obolibrary.org/obo/GO_0070160 GO:0070169 biolink:BiologicalProcess positive regulation of biomineral tissue development Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. go.json http://purl.obolibrary.org/obo/GO_0070169 GO:0070167 biolink:BiologicalProcess regulation of biomineral tissue development Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. go.json http://purl.obolibrary.org/obo/GO_0070167 GO:0070168 biolink:BiologicalProcess negative regulation of biomineral tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. go.json http://purl.obolibrary.org/obo/GO_0070168 GO:0070165 biolink:BiologicalProcess positive regulation of adiponectin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell. go.json activation of adiponectin secretion|stimulation of adiponectin secretion|up regulation of adiponectin secretion|up-regulation of adiponectin secretion|upregulation of adiponectin secretion http://purl.obolibrary.org/obo/GO_0070165 GO:0070166 biolink:BiologicalProcess enamel mineralization The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. go.json enamel formation http://purl.obolibrary.org/obo/GO_0070166 GO:0070196 biolink:BiologicalProcess eukaryotic translation initiation factor 3 complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex. go.json eIF-3 assembly|eIF3 assembly http://purl.obolibrary.org/obo/GO_0070196 GO:0070197 biolink:BiologicalProcess meiotic attachment of telomere to nuclear envelope The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation. go.json attachment of telomeres to nuclear envelope|attachment of telomeric chromatin to nuclear envelope http://purl.obolibrary.org/obo/GO_0070197 GO:0070194 biolink:BiologicalProcess synaptonemal complex disassembly The controlled breakdown of a synaptonemal complex. go.json http://purl.obolibrary.org/obo/GO_0070194 GO:0070195 biolink:CellularComponent growth hormone receptor complex A receptor complex that consists of two identical subunits and binds growth hormone. go.json http://purl.obolibrary.org/obo/GO_0070195 GO:0070192 biolink:BiologicalProcess chromosome organization involved in meiotic cell cycle A process of chromosome organization that is involved in a meiotic cell cycle. go.json chromosome organisation involved in meiosis|meiotic chromosome organization http://purl.obolibrary.org/obo/GO_0070192 GO:0070193 biolink:BiologicalProcess synaptonemal complex organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. go.json synaptonemal complex organisation http://purl.obolibrary.org/obo/GO_0070193 GO:0070190 biolink:MolecularActivity obsolete inositol hexakisphosphate 1-kinase or 3-kinase activity OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate. go.json inositol hexakisphosphate 1-kinase or 3-kinase activity True http://purl.obolibrary.org/obo/GO_0070190 GO:0070191 biolink:MolecularActivity obsolete methionine-R-sulfoxide reductase activity OBSOLETE. Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin. go.json True http://purl.obolibrary.org/obo/GO_0070191 GO:0070198 biolink:BiologicalProcess protein localization to chromosome, telomeric region Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. go.json protein localisation to chromosome, telomeric region|protein localization to telomere http://purl.obolibrary.org/obo/GO_0070198 GO:0070199 biolink:BiologicalProcess establishment of protein localization to chromosome The directed movement of a protein to a specific location on a chromosome. go.json establishment of protein localisation to chromosome http://purl.obolibrary.org/obo/GO_0070199 GO:0070185 biolink:BiologicalProcess mitochondrial valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070185 GO:0070186 biolink:MolecularActivity growth hormone activity The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth. go.json GH activity|pituitary growth hormone activity|placental growth hormone activity http://purl.obolibrary.org/obo/GO_0070186 GO:0070183 biolink:BiologicalProcess mitochondrial tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070183 GO:0070184 biolink:BiologicalProcess mitochondrial tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. go.json http://purl.obolibrary.org/obo/GO_0070184 GO:0070181 biolink:MolecularActivity small ribosomal subunit rRNA binding Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. go.json 18S rRNA binding|SSU rRNA binding http://purl.obolibrary.org/obo/GO_0070181 GO:0070182 biolink:MolecularActivity DNA polymerase binding Binding to a DNA polymerase. go.json http://purl.obolibrary.org/obo/GO_0070182 GO:0070180 biolink:MolecularActivity large ribosomal subunit rRNA binding Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. go.json 25S rRNA binding|LSU rRNA binding http://purl.obolibrary.org/obo/GO_0070180 GO:0070189 biolink:BiologicalProcess kynurenine metabolic process The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. go.json kynurenine metabolism http://purl.obolibrary.org/obo/GO_0070189 GO:0070187 biolink:CellularComponent shelterin complex A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. go.json Pot1 complex|Pot1-Tpz1 complex|telosome http://purl.obolibrary.org/obo/GO_0070187 GO:0070188 biolink:CellularComponent obsolete Stn1-Ten1 complex OBSOLETE. A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present. go.json True http://purl.obolibrary.org/obo/GO_0070188 GO:0035793 biolink:BiologicalProcess positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway. go.json positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway|positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway|positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway http://purl.obolibrary.org/obo/GO_0035793 GO:0035794 biolink:BiologicalProcess positive regulation of mitochondrial membrane permeability Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. go.json MPT|mitochondrial membrane permeability transition|mitochondrial membrane permeabilization|mitochondrial permeability transition|positive regulation of transport across mitochondrial membrane http://purl.obolibrary.org/obo/GO_0035794 GO:0035795 biolink:BiologicalProcess negative regulation of mitochondrial membrane permeability Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. go.json mitochondrial membrane impermeability|mitochondrial membrane impermeabilization|negative regulation of transport across mitochondrial membrane http://purl.obolibrary.org/obo/GO_0035795 GO:0035796 biolink:CellularComponent ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP. go.json ATP-binding cassette (ABC) transporter complex, ECF-type|energy coupling factor (ECF)-type ABC transporter|energy-coupling factor transporter http://purl.obolibrary.org/obo/GO_0035796 GO:0035797 biolink:MolecularActivity tellurite methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride). go.json S-adenosyl-L-methionine-dependent tellurite methyltransferase activity|SAM-dependent tellurite methyltransferase activity|tellurite methylase activity http://purl.obolibrary.org/obo/GO_0035797 GO:0035798 biolink:MolecularActivity 2-alkenal reductase (NADP+) activity Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+. go.json NADPH:2-alkenal alpha,beta-hydrogenase activity http://purl.obolibrary.org/obo/GO_0035798 GO:0035799 biolink:BiologicalProcess ureter maturation A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. go.json http://purl.obolibrary.org/obo/GO_0035799 GO:0035790 biolink:BiologicalProcess platelet-derived growth factor receptor-alpha signaling pathway The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json PDGF receptor-alpha signaling pathway|PDGFR-alpha signaling pathway|alphaPDGF receptor signaling pathway|platelet-derived growth factor receptor-alpha signalling pathway http://purl.obolibrary.org/obo/GO_0035790 GO:0035791 biolink:BiologicalProcess platelet-derived growth factor receptor-beta signaling pathway The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json PDGF receptor-beta signaling pathway|PDGFR-beta signaling pathway|betaPDGF receptor signaling pathway|platelet-derived growth factor receptor-beta signalling pathway http://purl.obolibrary.org/obo/GO_0035791 GO:0035792 biolink:CellularComponent host cell postsynaptic membrane A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane. go.json other organism post-synaptic membrane|other organism postsynaptic membrane http://purl.obolibrary.org/obo/GO_0035792 GO:1901608 biolink:BiologicalProcess regulation of vesicle transport along microtubule Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. go.json regulation of microtubule-based vesicle localization http://purl.obolibrary.org/obo/GO_1901608 GO:1901609 biolink:BiologicalProcess negative regulation of vesicle transport along microtubule Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. go.json down regulation of microtubule-based vesicle localization|down regulation of vesicle transport along microtubule|down-regulation of microtubule-based vesicle localization|down-regulation of vesicle transport along microtubule|downregulation of microtubule-based vesicle localization|downregulation of vesicle transport along microtubule|inhibition of microtubule-based vesicle localization|inhibition of vesicle transport along microtubule|negative regulation of microtubule-based vesicle localization http://purl.obolibrary.org/obo/GO_1901609 GO:1901606 biolink:BiologicalProcess alpha-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. go.json alpha-amino acid breakdown|alpha-amino acid catabolism|alpha-amino acid degradation http://purl.obolibrary.org/obo/GO_1901606 GO:1901607 biolink:BiologicalProcess alpha-amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of an alpha-amino acid. go.json alpha-amino acid anabolism|alpha-amino acid biosynthesis|alpha-amino acid formation|alpha-amino acid synthesis http://purl.obolibrary.org/obo/GO_1901607 GO:1901604 biolink:MolecularActivity dethiobiotin transmembrane transporter activity Enables the transfer of dethiobiotin from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901604 GO:1901605 biolink:BiologicalProcess alpha-amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid. go.json alpha-amino acid metabolism http://purl.obolibrary.org/obo/GO_1901605 GO:1901602 biolink:MolecularActivity dethiobiotin binding Binding to dethiobiotin. go.json http://purl.obolibrary.org/obo/GO_1901602 GO:1901603 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901603 GO:0045116 biolink:BiologicalProcess protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. go.json RUB1-protein conjugation http://purl.obolibrary.org/obo/GO_0045116 GO:1901600 biolink:BiologicalProcess strigolactone metabolic process The chemical reactions and pathways involving strigolactone. go.json strigolactone metabolism http://purl.obolibrary.org/obo/GO_1901600 GO:0045117 biolink:BiologicalProcess azole transmembrane transport The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. go.json azole transport http://purl.obolibrary.org/obo/GO_0045117 GO:1901601 biolink:BiologicalProcess strigolactone biosynthetic process The chemical reactions and pathways resulting in the formation of strigolactone. go.json strigolactone anabolism|strigolactone biosynthesis|strigolactone formation|strigolactone synthesis http://purl.obolibrary.org/obo/GO_1901601 GO:0045114 biolink:BiologicalProcess beta 2 integrin biosynthetic process The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit. go.json beta 2 integrin anabolism|beta 2 integrin biosynthesis|beta 2 integrin formation|beta 2 integrin synthesis http://purl.obolibrary.org/obo/GO_0045114 GO:0045115 biolink:BiologicalProcess regulation of beta 2 integrin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. go.json regulation of beta 2 integrin anabolism|regulation of beta 2 integrin biosynthesis|regulation of beta 2 integrin formation|regulation of beta 2 integrin synthesis http://purl.obolibrary.org/obo/GO_0045115 GO:0045112 biolink:BiologicalProcess integrin biosynthetic process The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules. go.json integrin anabolism|integrin biosynthesis|integrin formation|integrin synthesis http://purl.obolibrary.org/obo/GO_0045112 GO:0045113 biolink:BiologicalProcess regulation of integrin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. go.json regulation of integrin anabolism|regulation of integrin biosynthesis|regulation of integrin formation|regulation of integrin synthesis http://purl.obolibrary.org/obo/GO_0045113 GO:0045110 biolink:BiologicalProcess intermediate filament bundle assembly The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs. go.json tonofilament assembly http://purl.obolibrary.org/obo/GO_0045110 GO:0045111 biolink:CellularComponent intermediate filament cytoskeleton Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. go.json http://purl.obolibrary.org/obo/GO_0045111 GO:0060750 biolink:BiologicalProcess epithelial cell proliferation involved in mammary gland duct elongation The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth. go.json http://purl.obolibrary.org/obo/GO_0060750 GO:0060751 biolink:BiologicalProcess branch elongation involved in mammary gland duct branching The developmental growth process in which a branch of a mammary gland duct elongates. go.json mammary gland duct branch elongation http://purl.obolibrary.org/obo/GO_0060751 GO:0060752 biolink:BiologicalProcess intestinal phytosterol absorption Any process in which phytosterols are taken up from the contents of the intestine. go.json http://purl.obolibrary.org/obo/GO_0060752 GO:0060753 biolink:BiologicalProcess regulation of mast cell chemotaxis Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0060753 GO:0060754 biolink:BiologicalProcess positive regulation of mast cell chemotaxis Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0060754 GO:0060755 biolink:BiologicalProcess negative regulation of mast cell chemotaxis Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0060755 GO:0045118 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045118 GO:0045119 biolink:MolecularActivity azole:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances. go.json azole:hydrogen antiporter activity|bicyclomycin/sulfathiazole:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0045119 GO:0060756 biolink:BiologicalProcess foraging behavior Behavior by which an organism locates food. go.json http://purl.obolibrary.org/obo/GO_0060756 GO:0060757 biolink:BiologicalProcess adult foraging behavior Behavior by which an adult locates food. go.json http://purl.obolibrary.org/obo/GO_0060757 GO:0060758 biolink:BiologicalProcess foraging behavior by probing substrate Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food. go.json http://purl.obolibrary.org/obo/GO_0060758 GO:0060759 biolink:BiologicalProcess regulation of response to cytokine stimulus Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. go.json http://purl.obolibrary.org/obo/GO_0060759 GO:1901619 biolink:BiologicalProcess obsolete tRNA methylation in response to nitrogen starvation OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule as a result of deprivation of nitrogen. go.json True http://purl.obolibrary.org/obo/GO_1901619 GO:0045120 biolink:CellularComponent pronucleus The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. Wikipedia:Pronucleus go.json http://purl.obolibrary.org/obo/GO_0045120 GO:1901617 biolink:BiologicalProcess organic hydroxy compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. go.json organic hydroxy compound anabolism|organic hydroxy compound biosynthesis|organic hydroxy compound formation|organic hydroxy compound synthesis http://purl.obolibrary.org/obo/GO_1901617 GO:1901618 biolink:MolecularActivity organic hydroxy compound transmembrane transporter activity Enables the transfer of organic hydroxy compound from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901618 GO:1901615 biolink:BiologicalProcess organic hydroxy compound metabolic process The chemical reactions and pathways involving organic hydroxy compound. go.json organic hydroxy compound metabolism http://purl.obolibrary.org/obo/GO_1901615 GO:1901616 biolink:BiologicalProcess organic hydroxy compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. go.json organic hydroxy compound breakdown|organic hydroxy compound catabolism|organic hydroxy compound degradation http://purl.obolibrary.org/obo/GO_1901616 GO:1901613 biolink:BiologicalProcess negative regulation of terminal button organization Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization. go.json down regulation of bouton organization|down regulation of presynaptic bouton organization|down regulation of synaptic bouton organization|down regulation of terminal bouton organization|down regulation of terminal button organisation|down regulation of terminal button organization|down-regulation of bouton organization|down-regulation of presynaptic bouton organization|down-regulation of synaptic bouton organization|down-regulation of terminal bouton organization|down-regulation of terminal button organisation|down-regulation of terminal button organization|downregulation of bouton organization|downregulation of presynaptic bouton organization|downregulation of synaptic bouton organization|downregulation of terminal bouton organization|downregulation of terminal button organisation|downregulation of terminal button organization|inhibition of bouton organization|inhibition of presynaptic bouton organization|inhibition of synaptic bouton organization|inhibition of terminal bouton organization|inhibition of terminal button organisation|inhibition of terminal button organization|negative regulation of bouton organization|negative regulation of presynaptic bouton organization|negative regulation of synaptic bouton organization|negative regulation of terminal bouton organization|negative regulation of terminal button organisation http://purl.obolibrary.org/obo/GO_1901613 GO:1901614 biolink:BiologicalProcess positive regulation of terminal button organization Any process that activates or increases the frequency, rate or extent of terminal button organization. go.json activation of bouton organization|activation of presynaptic bouton organization|activation of synaptic bouton organization|activation of terminal bouton organization|activation of terminal button organisation|activation of terminal button organization|positive regulation of bouton organization|positive regulation of presynaptic bouton organization|positive regulation of synaptic bouton organization|positive regulation of terminal bouton organization|positive regulation of terminal button organisation|up regulation of bouton organization|up regulation of presynaptic bouton organization|up regulation of synaptic bouton organization|up regulation of terminal bouton organization|up regulation of terminal button organisation|up regulation of terminal button organization|up-regulation of bouton organization|up-regulation of presynaptic bouton organization|up-regulation of synaptic bouton organization|up-regulation of terminal bouton organization|up-regulation of terminal button organisation|up-regulation of terminal button organization|upregulation of bouton organization|upregulation of presynaptic bouton organization|upregulation of synaptic bouton organization|upregulation of terminal bouton organization|upregulation of terminal button organisation|upregulation of terminal button organization http://purl.obolibrary.org/obo/GO_1901614 GO:0045127 biolink:MolecularActivity N-acetylglucosamine kinase activity Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+. EC:2.7.1.59|KEGG_REACTION:R01201|MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN|RHEA:17417|Reactome:R-HSA-6803771 go.json 2-acetylamino-2-deoxy-D-glucose kinase activity|ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity|ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity|GlcNAc kinase activity|acetylaminodeoxyglucokinase activity|acetylglucosamine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0045127 GO:1901611 biolink:MolecularActivity phosphatidylglycerol binding Binding to phosphatidylglycerol. go.json http://purl.obolibrary.org/obo/GO_1901611 GO:0045128 biolink:BiologicalProcess negative regulation of reciprocal meiotic recombination Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json down regulation of meiotic recombination|down-regulation of meiotic recombination|downregulation of meiotic recombination|inhibition of meiotic recombination|suppression of meiotic recombination http://purl.obolibrary.org/obo/GO_0045128 GO:1901612 biolink:MolecularActivity cardiolipin binding Binding to cardiolipin. go.json http://purl.obolibrary.org/obo/GO_1901612 GO:0045125 biolink:MolecularActivity bioactive lipid receptor activity Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. go.json http://purl.obolibrary.org/obo/GO_0045125 GO:1901610 biolink:BiologicalProcess positive regulation of vesicle transport along microtubule Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. go.json activation of microtubule-based vesicle localization|activation of vesicle transport along microtubule|positive regulation of microtubule-based vesicle localization|up regulation of microtubule-based vesicle localization|up regulation of vesicle transport along microtubule|up-regulation of microtubule-based vesicle localization|up-regulation of vesicle transport along microtubule|upregulation of microtubule-based vesicle localization|upregulation of vesicle transport along microtubule http://purl.obolibrary.org/obo/GO_1901610 GO:0045126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045126 GO:0045123 biolink:BiologicalProcess cellular extravasation The migration of a leukocyte from the blood vessels into the surrounding tissue. Wikipedia:Leukocyte_extravasation go.json immune cell cellular extravasation|leucocyte cellular extravasation|leukocyte cellular extravasation|transendothelial leukocyte migration http://purl.obolibrary.org/obo/GO_0045123 GO:0045124 biolink:BiologicalProcess regulation of bone resorption Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). go.json http://purl.obolibrary.org/obo/GO_0045124 GO:0045121 biolink:CellularComponent membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. Wikipedia:Lipid_raft go.json GEM domain|glycolipid-enriched membrane domain|lipid raft http://purl.obolibrary.org/obo/GO_0045121 GO:0045122 biolink:BiologicalProcess aflatoxin biosynthetic process The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. go.json aflatoxin anabolism|aflatoxin biosynthesis|aflatoxin formation|aflatoxin synthesis http://purl.obolibrary.org/obo/GO_0045122 GO:0060740 biolink:BiologicalProcess prostate gland epithelium morphogenesis The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. go.json http://purl.obolibrary.org/obo/GO_0060740 GO:0060741 biolink:BiologicalProcess prostate gland stromal morphogenesis The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland. go.json http://purl.obolibrary.org/obo/GO_0060741 GO:0060742 biolink:BiologicalProcess epithelial cell differentiation involved in prostate gland development The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. go.json http://purl.obolibrary.org/obo/GO_0060742 GO:0060743 biolink:BiologicalProcess epithelial cell maturation involved in prostate gland development The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. go.json prostate gland epithelial cell development http://purl.obolibrary.org/obo/GO_0060743 GO:0045129 biolink:MolecularActivity NAD-independent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone. go.json AcuC http://purl.obolibrary.org/obo/GO_0045129 GO:0060744 biolink:BiologicalProcess mammary gland branching involved in thelarche The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. go.json mammary gland branching involved in puberty http://purl.obolibrary.org/obo/GO_0060744 GO:0060745 biolink:BiologicalProcess mammary gland branching involved in pregnancy The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy. go.json http://purl.obolibrary.org/obo/GO_0060745 GO:0060746 biolink:BiologicalProcess parental behavior A reproductive behavior in which a parent cares for and rears offspring. go.json http://purl.obolibrary.org/obo/GO_0060746 GO:0060747 biolink:BiologicalProcess oral incubation A parental behavior in which fertilized eggs are taken into the mouth and held until hatching. go.json http://purl.obolibrary.org/obo/GO_0060747 GO:0060748 biolink:BiologicalProcess tertiary branching involved in mammary gland duct morphogenesis The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy. go.json http://purl.obolibrary.org/obo/GO_0060748 GO:0060749 biolink:BiologicalProcess mammary gland alveolus development The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. go.json http://purl.obolibrary.org/obo/GO_0060749 GO:0045130 biolink:MolecularActivity keratan sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. EC:2.8.2.21|MetaCyc:KERATAN-SULFOTRANSFERASE-RXN|Reactome:R-HSA-2046175 go.json 3'-phosphoadenylyl keratan sulfotransferase activity|3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity|3'-phosphoadenylylsulfate:keratan sulfotransferase activity|keratan sulfate Gal-6-sulfotransferase activity|keratan sulfate sulfotransferase activity|keratan sulphotransferase activity http://purl.obolibrary.org/obo/GO_0045130 GO:0045131 biolink:MolecularActivity pre-mRNA branch point binding Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site. go.json http://purl.obolibrary.org/obo/GO_0045131 GO:1901628 biolink:BiologicalProcess positive regulation of postsynaptic membrane organization Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization. go.json activation of postsynaptic membrane organisation|activation of postsynaptic membrane organization|positive regulation of post-synaptic membrane organization|positive regulation of postsynaptic membrane organisation|up regulation of postsynaptic membrane organisation|up regulation of postsynaptic membrane organization|up-regulation of postsynaptic membrane organisation|up-regulation of postsynaptic membrane organization|upregulation of postsynaptic membrane organisation|upregulation of postsynaptic membrane organization http://purl.obolibrary.org/obo/GO_1901628 GO:1901629 biolink:BiologicalProcess regulation of presynaptic membrane organization Any process that modulates the frequency, rate or extent of presynaptic membrane organization. go.json regulation of pre-synaptic membrane organization|regulation of presynaptic membrane organisation http://purl.obolibrary.org/obo/GO_1901629 GO:1901626 biolink:BiologicalProcess regulation of postsynaptic membrane organization Any process that modulates the frequency, rate or extent of postsynaptic membrane organization. go.json regulation of post-synaptic membrane organization|regulation of postsynaptic membrane organisation http://purl.obolibrary.org/obo/GO_1901626 GO:1901627 biolink:BiologicalProcess negative regulation of postsynaptic membrane organization Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization. go.json down regulation of postsynaptic membrane organisation|down regulation of postsynaptic membrane organization|down-regulation of postsynaptic membrane organisation|down-regulation of postsynaptic membrane organization|downregulation of postsynaptic membrane organisation|downregulation of postsynaptic membrane organization|inhibition of postsynaptic membrane organisation|inhibition of postsynaptic membrane organization|negative regulation of post-synaptic membrane organization|negative regulation of postsynaptic membrane organisation http://purl.obolibrary.org/obo/GO_1901627 GO:1901624 biolink:BiologicalProcess negative regulation of lymphocyte chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis. go.json down regulation of lymphocyte chemotaxis|down-regulation of lymphocyte chemotaxis|downregulation of lymphocyte chemotaxis|inhibition of lymphocyte chemotaxis http://purl.obolibrary.org/obo/GO_1901624 GO:1901625 biolink:BiologicalProcess cellular response to ergosterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus. go.json http://purl.obolibrary.org/obo/GO_1901625 GO:1901622 biolink:BiologicalProcess positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Any process that activates or increases the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. go.json activation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|activation of hh signaling pathway involved in dorsal/ventral neural tube patterning|activation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|activation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|positive regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|positive regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|positive regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|up regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|up regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|up regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|up regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|up-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|up-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|up-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|up-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|upregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|upregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|upregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|upregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning http://purl.obolibrary.org/obo/GO_1901622 GO:0045138 biolink:BiologicalProcess nematode male tail tip morphogenesis The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome. go.json male tail morphogenesis|male tail tip morphogenesis|tail tip morphogenesis http://purl.obolibrary.org/obo/GO_0045138 GO:1901623 biolink:BiologicalProcess regulation of lymphocyte chemotaxis Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_1901623 GO:0045139 biolink:BiologicalProcess obsolete copper sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json copper sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0045139 GO:1901620 biolink:BiologicalProcess regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. go.json regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning http://purl.obolibrary.org/obo/GO_1901620 GO:0045136 biolink:BiologicalProcess development of secondary sexual characteristics The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0045136 GO:1901621 biolink:BiologicalProcess negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. go.json down regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|down regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|down regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|down regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|down-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|down-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|down-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|down-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|downregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|downregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|downregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|downregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|inhibition of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|inhibition of hh signaling pathway involved in dorsal/ventral neural tube patterning|inhibition of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|inhibition of smoothened signalling pathway involved in dorsal/ventral neural tube patterning|negative regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning|negative regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning|negative regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning http://purl.obolibrary.org/obo/GO_1901621 GO:0045137 biolink:BiologicalProcess development of primary sexual characteristics The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0045137 GO:0045134 biolink:MolecularActivity UDP phosphatase activity Catalysis of the reaction: UDP + H2O = UMP + phosphate. KEGG_REACTION:R00155|MetaCyc:RXN-12197|RHEA:64876 go.json UDP phosphohydrolase activity|UDPase activity|uridine 5'-diphosphatase activity|uridine diphosphatase activity|uridine-diphosphatase activity http://purl.obolibrary.org/obo/GO_0045134 GO:0045135 biolink:MolecularActivity poly(beta-D-mannuronate) lyase activity Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. EC:4.2.2.3|MetaCyc:4.2.2.3-RXN go.json alginase I|alginase activity|alginate lyase I activity|alginate lyase activity|poly(beta-D-1,4-mannuronide) lyase activity|poly(mana) alginate lyase activity http://purl.obolibrary.org/obo/GO_0045135 GO:0045132 biolink:BiologicalProcess meiotic chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0045132 GO:0045133 biolink:MolecularActivity 2,3-dihydroxybenzoate 3,4-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+. EC:1.13.11.14|KEGG_REACTION:R01507|MetaCyc:1.13.11.14-RXN|RHEA:18477 go.json 2,3-dihydroxybenzoate 1,2-dioxygenase activity|2,3-dihydroxybenzoate oxygenase activity|2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)|2,3-dihydroxybenzoic oxygenase activity|o-pyrocatechuate oxygenase activity http://purl.obolibrary.org/obo/GO_0045133 GO:0060770 biolink:BiologicalProcess negative regulation of epithelial cell proliferation involved in prostate gland development Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. go.json http://purl.obolibrary.org/obo/GO_0060770 GO:0060771 biolink:BiologicalProcess phyllotactic patterning The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis. go.json http://purl.obolibrary.org/obo/GO_0060771 GO:0060772 biolink:BiologicalProcess leaf phyllotactic patterning The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem. go.json http://purl.obolibrary.org/obo/GO_0060772 GO:0060773 biolink:BiologicalProcess flower phyllotactic patterning The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium. go.json http://purl.obolibrary.org/obo/GO_0060773 GO:0060774 biolink:BiologicalProcess auxin mediated signaling pathway involved in phyllotactic patterning The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem. go.json auxin mediated signalling pathway involved in phyllotactic patterning http://purl.obolibrary.org/obo/GO_0060774 GO:0060775 biolink:BiologicalProcess planar cell polarity pathway involved in gastrula mediolateral intercalation The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation. go.json http://purl.obolibrary.org/obo/GO_0060775 GO:0060776 biolink:BiologicalProcess simple leaf morphogenesis The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided. go.json http://purl.obolibrary.org/obo/GO_0060776 GO:0060777 biolink:BiologicalProcess compound leaf morphogenesis The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development. go.json http://purl.obolibrary.org/obo/GO_0060777 GO:0060778 biolink:BiologicalProcess primary leaflet morphogenesis The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis. go.json http://purl.obolibrary.org/obo/GO_0060778 GO:0060779 biolink:BiologicalProcess secondary leaflet morphogenesis The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet. go.json http://purl.obolibrary.org/obo/GO_0060779 GO:0045141 biolink:BiologicalProcess meiotic telomere clustering The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis. go.json bouquet biosynthesis|bouquet formation http://purl.obolibrary.org/obo/GO_0045141 GO:0045142 biolink:MolecularActivity triplex DNA binding Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. go.json http://purl.obolibrary.org/obo/GO_0045142 GO:1901639 biolink:BiologicalProcess obsolete XDP catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of XDP. go.json XDP breakdown|XDP catabolism|XDP degradation True http://purl.obolibrary.org/obo/GO_1901639 GO:0045140 biolink:MolecularActivity inositol phosphoceramide synthase activity Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol. EC:2.7.1.227|MetaCyc:RXN3O-581 go.json IPC synthase activity http://purl.obolibrary.org/obo/GO_0045140 GO:1901637 biolink:BiologicalProcess obsolete positive regulation of maintenance of presynaptic active zone structure OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of presynaptic active zone structure. go.json activation of maintenance of presynaptic active zone structure|positive regulation of maintenance of presynaptic active zone structure|up regulation of maintenance of presynaptic active zone structure|up-regulation of maintenance of presynaptic active zone structure|upregulation of maintenance of presynaptic active zone structure True http://purl.obolibrary.org/obo/GO_1901637 GO:1901638 biolink:BiologicalProcess obsolete copper ion import into ascospore-type prospore OBSOLETE. Any copper ion import that takes place in ascospore-type prospore. go.json copper ion import into ascospore-type prospore|copper ion uptake in ascospore-type prospore True http://purl.obolibrary.org/obo/GO_1901638 GO:1901635 biolink:BiologicalProcess obsolete regulation of maintenance of presynaptic active zone structure OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of presynaptic active zone structure. go.json regulation of maintenance of presynaptic active zone structure True http://purl.obolibrary.org/obo/GO_1901635 GO:1901636 biolink:BiologicalProcess obsolete negative regulation of maintenance of presynaptic active zone structure OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of presynaptic active zone structure. go.json down regulation of maintenance of presynaptic active zone structure|down-regulation of maintenance of presynaptic active zone structure|downregulation of maintenance of presynaptic active zone structure|inhibition of maintenance of presynaptic active zone structure|negative regulation of maintenance of presynaptic active zone structure True http://purl.obolibrary.org/obo/GO_1901636 GO:1901633 biolink:BiologicalProcess negative regulation of synaptic vesicle membrane organization Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle membrane organization. go.json down regulation of SLMV biogenesis|down regulation of synaptic vesicle membrane organisation|down regulation of synaptic vesicle membrane organization|down regulation of synaptic vesicle membrane organization and biogenesis|down-regulation of SLMV biogenesis|down-regulation of synaptic vesicle membrane organisation|down-regulation of synaptic vesicle membrane organization|down-regulation of synaptic vesicle membrane organization and biogenesis|downregulation of SLMV biogenesis|downregulation of synaptic vesicle membrane organisation|downregulation of synaptic vesicle membrane organization|downregulation of synaptic vesicle membrane organization and biogenesis|inhibition of SLMV biogenesis|inhibition of synaptic vesicle membrane organisation|inhibition of synaptic vesicle membrane organization|inhibition of synaptic vesicle membrane organization and biogenesis|negative regulation of SLMV biogenesis|negative regulation of synaptic vesicle membrane organisation|negative regulation of synaptic vesicle membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_1901633 GO:0045149 biolink:BiologicalProcess acetoin metabolic process The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source. go.json acetoin metabolism http://purl.obolibrary.org/obo/GO_0045149 GO:1901634 biolink:BiologicalProcess positive regulation of synaptic vesicle membrane organization Any process that activates or increases the frequency, rate or extent of synaptic vesicle membrane organization. go.json activation of SLMV biogenesis|activation of synaptic vesicle membrane organisation|activation of synaptic vesicle membrane organization|activation of synaptic vesicle membrane organization and biogenesis|positive regulation of SLMV biogenesis|positive regulation of synaptic vesicle membrane organisation|positive regulation of synaptic vesicle membrane organization and biogenesis|up regulation of SLMV biogenesis|up regulation of synaptic vesicle membrane organisation|up regulation of synaptic vesicle membrane organization|up regulation of synaptic vesicle membrane organization and biogenesis|up-regulation of SLMV biogenesis|up-regulation of synaptic vesicle membrane organisation|up-regulation of synaptic vesicle membrane organization|up-regulation of synaptic vesicle membrane organization and biogenesis|upregulation of SLMV biogenesis|upregulation of synaptic vesicle membrane organisation|upregulation of synaptic vesicle membrane organization|upregulation of synaptic vesicle membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_1901634 GO:0045147 biolink:BiologicalProcess regulation of initiation of acetate catabolic process by acetate Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. go.json regulation of initiation of acetate breakdown by acetate|regulation of initiation of acetate degradation by acetate http://purl.obolibrary.org/obo/GO_0045147 GO:1901631 biolink:BiologicalProcess positive regulation of presynaptic membrane organization Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization. go.json activation of presynaptic membrane organisation|activation of presynaptic membrane organization|positive regulation of pre-synaptic membrane organization|positive regulation of presynaptic membrane organisation|up regulation of presynaptic membrane organisation|up regulation of presynaptic membrane organization|up-regulation of presynaptic membrane organisation|up-regulation of presynaptic membrane organization|upregulation of presynaptic membrane organisation|upregulation of presynaptic membrane organization http://purl.obolibrary.org/obo/GO_1901631 GO:0045148 biolink:MolecularActivity tripeptide aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide. EC:3.4.11.4|MetaCyc:3.4.11.4-RXN go.json alanine-phenylalanine-proline arylamidase activity|aminoexotripeptidase activity|aminotripeptidase activity|imidoendopeptidase activity|lymphopeptidase activity|peptidase B|peptidase T http://purl.obolibrary.org/obo/GO_0045148 GO:1901632 biolink:BiologicalProcess regulation of synaptic vesicle membrane organization Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization. go.json regulation of SLMV biogenesis|regulation of synaptic vesicle membrane organisation|regulation of synaptic vesicle membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_1901632 GO:0045145 biolink:MolecularActivity single-stranded DNA 5'-3' DNA exonuclease activity Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. go.json single-stranded DNA specific 5'-3' exodeoxyribonuclease activity|ssDNA-specific 5'-3' exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0045145 GO:1901630 biolink:BiologicalProcess negative regulation of presynaptic membrane organization Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization. go.json down regulation of presynaptic membrane organisation|down regulation of presynaptic membrane organization|down-regulation of presynaptic membrane organisation|down-regulation of presynaptic membrane organization|downregulation of presynaptic membrane organisation|downregulation of presynaptic membrane organization|inhibition of presynaptic membrane organisation|inhibition of presynaptic membrane organization|negative regulation of pre-synaptic membrane organization|negative regulation of presynaptic membrane organisation http://purl.obolibrary.org/obo/GO_1901630 GO:0045146 biolink:BiologicalProcess initiation of acetate catabolic process by acetate The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. go.json initiation of acetate breakdown by acetate|initiation of acetate degradation by acetate http://purl.obolibrary.org/obo/GO_0045146 GO:0045143 biolink:BiologicalProcess homologous chromosome segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. go.json meiosis I, chromosome segregation http://purl.obolibrary.org/obo/GO_0045143 GO:0045144 biolink:BiologicalProcess meiotic sister chromatid segregation The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle. go.json meiosis II, chromosome segregation http://purl.obolibrary.org/obo/GO_0045144 GO:0060760 biolink:BiologicalProcess positive regulation of response to cytokine stimulus Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. go.json http://purl.obolibrary.org/obo/GO_0060760 GO:0060761 biolink:BiologicalProcess negative regulation of response to cytokine stimulus Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. go.json http://purl.obolibrary.org/obo/GO_0060761 GO:0060762 biolink:BiologicalProcess regulation of branching involved in mammary gland duct morphogenesis Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0060762 GO:0060763 biolink:BiologicalProcess mammary duct terminal end bud growth The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty. go.json http://purl.obolibrary.org/obo/GO_0060763 GO:0060764 biolink:BiologicalProcess cell-cell signaling involved in mammary gland development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure. go.json cell-cell signalling involved in mammary gland development http://purl.obolibrary.org/obo/GO_0060764 GO:0060765 biolink:BiologicalProcess regulation of androgen receptor signaling pathway Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. go.json regulation of androgen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060765 GO:0060766 biolink:BiologicalProcess negative regulation of androgen receptor signaling pathway Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. go.json negative regulation of androgen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060766 GO:0060767 biolink:BiologicalProcess epithelial cell proliferation involved in prostate gland development The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time. go.json http://purl.obolibrary.org/obo/GO_0060767 GO:0060768 biolink:BiologicalProcess regulation of epithelial cell proliferation involved in prostate gland development Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. go.json http://purl.obolibrary.org/obo/GO_0060768 GO:0060769 biolink:BiologicalProcess positive regulation of epithelial cell proliferation involved in prostate gland development Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. go.json http://purl.obolibrary.org/obo/GO_0060769 GO:0045152 biolink:MolecularActivity antisigma factor binding Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. go.json antisigma factor antagonist activity http://purl.obolibrary.org/obo/GO_0045152 GO:0045153 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045153 GO:0045150 biolink:BiologicalProcess acetoin catabolic process The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. go.json acetoin breakdown|acetoin catabolism|acetoin degradation http://purl.obolibrary.org/obo/GO_0045150 GO:0045151 biolink:BiologicalProcess acetoin biosynthetic process The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone. go.json acetoin anabolism|acetoin biosynthesis|acetoin formation|acetoin synthesis http://purl.obolibrary.org/obo/GO_0045151 GO:1901648 biolink:BiologicalProcess obsolete regulation of actomyosin contractile ring localization OBSOLETE. Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization. go.json regulation of contractile ring localisation involved in cell cycle cytokinesis|regulation of contractile ring localization involved in cell cycle cytokinesis True http://purl.obolibrary.org/obo/GO_1901648 GO:1901649 biolink:BiologicalProcess obsolete negative regulation of actomyosin contractile ring localization OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of actomyosin contractile ring localization. go.json True http://purl.obolibrary.org/obo/GO_1901649 GO:1901646 biolink:BiologicalProcess negative regulation of synoviocyte proliferation Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation. go.json down regulation of synoviocyte proliferation|down-regulation of synoviocyte proliferation|downregulation of synoviocyte proliferation|inhibition of synoviocyte proliferation http://purl.obolibrary.org/obo/GO_1901646 GO:1901647 biolink:BiologicalProcess positive regulation of synoviocyte proliferation Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation. go.json activation of synoviocyte proliferation|up regulation of synoviocyte proliferation|up-regulation of synoviocyte proliferation|upregulation of synoviocyte proliferation http://purl.obolibrary.org/obo/GO_1901647 GO:1901644 biolink:BiologicalProcess obsolete positive regulation of tRNA methylation in response to nitrogen starvation OBSOLETE. Any process that activates or increases the frequency, rate or extent of tRNA methylation in response to nitrogen starvation. go.json activation of tRNA methylation in response to nitrogen starvation|up regulation of tRNA methylation in response to nitrogen starvation|up-regulation of tRNA methylation in response to nitrogen starvation|upregulation of tRNA methylation in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_1901644 GO:1901645 biolink:BiologicalProcess regulation of synoviocyte proliferation Any process that modulates the frequency, rate or extent of synoviocyte proliferation. go.json http://purl.obolibrary.org/obo/GO_1901645 GO:1901642 biolink:BiologicalProcess nucleoside transmembrane transport The directed movement of nucleoside across a membrane. go.json nucleoside membrane transport http://purl.obolibrary.org/obo/GO_1901642 GO:0045158 biolink:MolecularActivity electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II. go.json cytochrome|cytochrome b/b6|cytochrome b6|cytochrome f http://purl.obolibrary.org/obo/GO_0045158 GO:1901643 biolink:BiologicalProcess obsolete regulation of tRNA methylation in response to nitrogen starvation OBSOLETE. Any process that modulates the frequency, rate or extent of tRNA methylation in response to nitrogen starvation. go.json True http://purl.obolibrary.org/obo/GO_1901643 GO:0045159 biolink:MolecularActivity myosin II binding Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. go.json http://purl.obolibrary.org/obo/GO_0045159 GO:0045156 biolink:MolecularActivity electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. go.json cytochrome|cytochrome bc1 complex http://purl.obolibrary.org/obo/GO_0045156 GO:1901640 biolink:MolecularActivity XTP binding Binding to XTP. go.json http://purl.obolibrary.org/obo/GO_1901640 GO:0060790 biolink:BiologicalProcess tooth placode formation The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud. go.json http://purl.obolibrary.org/obo/GO_0060790 GO:0045157 biolink:MolecularActivity electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis. go.json cytochrome http://purl.obolibrary.org/obo/GO_0045157 GO:1901641 biolink:MolecularActivity ITP binding Binding to ITP. go.json http://purl.obolibrary.org/obo/GO_1901641 GO:0060791 biolink:BiologicalProcess sebaceous gland placode formation The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud. go.json http://purl.obolibrary.org/obo/GO_0060791 GO:0045154 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045154 GO:0060792 biolink:BiologicalProcess sweat gland development The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation. go.json http://purl.obolibrary.org/obo/GO_0060792 GO:0045155 biolink:MolecularActivity obsolete electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity OBSOLETE. Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex. go.json cytochrome|cytochrome c True http://purl.obolibrary.org/obo/GO_0045155 GO:0060793 biolink:BiologicalProcess sweat gland placode formation The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud. go.json http://purl.obolibrary.org/obo/GO_0060793 GO:0060794 biolink:BiologicalProcess leaflet morphogenesis The process in which the anatomical structures of the leaflet are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060794 GO:0060795 biolink:BiologicalProcess cell fate commitment involved in formation of primary germ layer The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0060795 GO:0060796 biolink:BiologicalProcess obsolete regulation of transcription involved in primary germ layer cell fate commitment OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate. go.json True http://purl.obolibrary.org/obo/GO_0060796 GO:0060797 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate. go.json transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment True http://purl.obolibrary.org/obo/GO_0060797 GO:0060798 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate. go.json transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification True http://purl.obolibrary.org/obo/GO_0060798 GO:0060799 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate. go.json transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification True http://purl.obolibrary.org/obo/GO_0060799 GO:0070118 biolink:CellularComponent organellar chromatophore thylakoid membrane The lipid bilayer membrane of any thylakoid within an organellar chromatophore. go.json Paulinella-type chromatophore thylakoid membrane http://purl.obolibrary.org/obo/GO_0070118 GO:0070119 biolink:MolecularActivity ciliary neurotrophic factor binding Binding to the cytokine ciliary neurotrophic factor. go.json CNTF binding http://purl.obolibrary.org/obo/GO_0070119 GO:0070116 biolink:CellularComponent organellar chromatophore thylakoid A thylakoid located in an organellar chromatophore. go.json Paulinella-type chromatophore thylakoid http://purl.obolibrary.org/obo/GO_0070116 GO:0070117 biolink:CellularComponent organellar chromatophore thylakoid lumen The volume enclosed by an organellar chromatophore thylakoid membrane. go.json Paulinella-type chromatophore thylakoid lumen http://purl.obolibrary.org/obo/GO_0070117 GO:0070114 biolink:CellularComponent organellar chromatophore outer membrane The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore. go.json Paulinella-type chromatophore outer membrane http://purl.obolibrary.org/obo/GO_0070114 GO:0070115 biolink:CellularComponent organellar chromatophore intermembrane space The region between the inner and outer lipid bilayers that surround an organellar chromatophore. go.json Paulinella-type chromatophore intermembrane space http://purl.obolibrary.org/obo/GO_0070115 GO:0070112 biolink:CellularComponent organellar chromatophore membrane Either of the lipid bilayers that surround an organellar chromatophore. go.json Paulinella-type chromatophore membrane http://purl.obolibrary.org/obo/GO_0070112 GO:0070113 biolink:CellularComponent organellar chromatophore inner membrane The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore. go.json Paulinella-type chromatophore inner membrane http://purl.obolibrary.org/obo/GO_0070113 GO:0070110 biolink:CellularComponent ciliary neurotrophic factor receptor complex A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR. go.json http://purl.obolibrary.org/obo/GO_0070110 GO:0070111 biolink:CellularComponent organellar chromatophore A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora. go.json Paulinella-type chromatophore http://purl.obolibrary.org/obo/GO_0070111 GO:0045163 biolink:BiologicalProcess clustering of voltage-gated potassium channels The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode. go.json Kv channel clustering|clustering of voltage gated potassium channels|clustering of voltage-dependent potassium channels|voltage-gated potassium channel clustering http://purl.obolibrary.org/obo/GO_0045163 GO:0045164 biolink:MolecularActivity obsolete secretin (sensu Mammalia) OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract. go.json secretin (sensu Mammalia) True http://purl.obolibrary.org/obo/GO_0045164 GO:0045161 biolink:BiologicalProcess neuronal ion channel clustering The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. go.json http://purl.obolibrary.org/obo/GO_0045161 GO:0045162 biolink:BiologicalProcess clustering of voltage-gated sodium channels The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization. go.json Nav channel clustering|clustering of voltage gated sodium channels|clustering of voltage-dependent sodium channels|voltage-gated sodium channel clustering http://purl.obolibrary.org/obo/GO_0045162 GO:1901659 biolink:BiologicalProcess glycosyl compound biosynthetic process The chemical reactions and pathways resulting in the formation of glycosyl compound. go.json glycosyl compound anabolism|glycosyl compound biosynthesis|glycosyl compound formation|glycosyl compound synthesis http://purl.obolibrary.org/obo/GO_1901659 GO:0045160 biolink:CellularComponent myosin I complex A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement. go.json http://purl.obolibrary.org/obo/GO_0045160 GO:1901657 biolink:BiologicalProcess glycosyl compound metabolic process The chemical reactions and pathways involving glycosyl compound. go.json glycosyl compound metabolism http://purl.obolibrary.org/obo/GO_1901657 GO:1901658 biolink:BiologicalProcess glycosyl compound catabolic process The chemical reactions and pathways resulting in the breakdown of glycosyl compound. go.json glycosyl compound breakdown|glycosyl compound catabolism|glycosyl compound degradation http://purl.obolibrary.org/obo/GO_1901658 GO:1901655 biolink:BiologicalProcess cellular response to ketone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. go.json http://purl.obolibrary.org/obo/GO_1901655 GO:1901656 biolink:BiologicalProcess glycoside transport The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901656 GO:1901653 biolink:BiologicalProcess cellular response to peptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. go.json http://purl.obolibrary.org/obo/GO_1901653 GO:0045169 biolink:CellularComponent fusome A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle. go.json http://purl.obolibrary.org/obo/GO_0045169 GO:1901654 biolink:BiologicalProcess response to ketone A response that results in a state of tolerance to ketone. go.json process resulting in tolerance to ketone http://purl.obolibrary.org/obo/GO_1901654 GO:1901651 biolink:BiologicalProcess obsolete regulation of mitotic chromosome decondensation OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic chromosome decondensation. go.json True http://purl.obolibrary.org/obo/GO_1901651 GO:0045167 biolink:BiologicalProcess asymmetric protein localization involved in cell fate determination Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types. go.json asymmetric protein localisation involved in cell fate determination|asymmetric protein localization involved in cell fate commitment|asymmetric protein localization resulting in cell fate commitment|cell fate commitment, asymmetric protein localization http://purl.obolibrary.org/obo/GO_0045167 GO:1901652 biolink:BiologicalProcess response to peptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. go.json http://purl.obolibrary.org/obo/GO_1901652 GO:0045168 biolink:BiologicalProcess cell-cell signaling involved in cell fate commitment Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. go.json cell fate commitment, cell-cell signaling|cell fate commitment, cell-cell signalling|cell-cell signaling during in cell fate commitment|cell-cell signaling resulting in cell fate commitment|cell-cell signalling during cell fate commitment|cell-cell signalling involved in cell fate specification|cell-cell signalling resulting in cell fate commitment http://purl.obolibrary.org/obo/GO_0045168 GO:0060780 biolink:BiologicalProcess intercalary leaflet morphogenesis The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets. go.json http://purl.obolibrary.org/obo/GO_0060780 GO:0045165 biolink:BiologicalProcess cell fate commitment The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. go.json http://purl.obolibrary.org/obo/GO_0045165 GO:0060781 biolink:BiologicalProcess mesenchymal cell proliferation involved in prostate gland development The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time. go.json http://purl.obolibrary.org/obo/GO_0060781 GO:1901650 biolink:BiologicalProcess obsolete positive regulation of actomyosin contractile ring localization OBSOLETE. Any process that activates or increases the frequency, rate or extent of actomyosin contractile ring localization. go.json True http://purl.obolibrary.org/obo/GO_1901650 GO:0045166 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045166 GO:0060782 biolink:BiologicalProcess regulation of mesenchymal cell proliferation involved in prostate gland development Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json http://purl.obolibrary.org/obo/GO_0060782 GO:0060783 biolink:BiologicalProcess mesenchymal smoothened signaling pathway involved in prostate gland development The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development. go.json mesenchymal hedgehog signaling pathway involved in prostate gland development|mesenchymal hh signaling pathway involved in prostate gland development|mesenchymal smoothened signalling pathway involved in prostate gland development http://purl.obolibrary.org/obo/GO_0060783 GO:0060784 biolink:BiologicalProcess regulation of cell proliferation involved in tissue homeostasis Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. go.json http://purl.obolibrary.org/obo/GO_0060784 GO:0060785 biolink:BiologicalProcess regulation of apoptosis involved in tissue homeostasis Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. go.json http://purl.obolibrary.org/obo/GO_0060785 GO:0070109 biolink:BiologicalProcess positive regulation of interleukin-27-mediated signaling pathway Any process that increases the rate, frequency or extent of an interleukin-27-mediated signaling pathway. go.json positive regulation of IL-27-mediated signaling pathway|positive regulation of IL27RA/IL6ST signaling pathway|positive regulation of interleukin-27-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070109 GO:0060786 biolink:BiologicalProcess regulation of cell differentiation involved in tissue homeostasis Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. go.json http://purl.obolibrary.org/obo/GO_0060786 GO:0060787 biolink:BiologicalProcess positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate. go.json positive regulation of posterior neural plate formation by FGF receptor signaling pathway|positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060787 GO:0060788 biolink:BiologicalProcess ectodermal placode formation The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. go.json http://purl.obolibrary.org/obo/GO_0060788 GO:0070107 biolink:BiologicalProcess regulation of interleukin-27-mediated signaling pathway Any process that modulates the rate, frequency or extent of an interleukin-27-mediated signaling pathway. go.json regulation of IL-27-mediated signaling pathway|regulation of IL27RA/IL6ST signaling pathway|regulation of interleukin-27-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070107 GO:0060789 biolink:BiologicalProcess hair follicle placode formation The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. go.json http://purl.obolibrary.org/obo/GO_0060789 GO:0070108 biolink:BiologicalProcess negative regulation of interleukin-27-mediated signaling pathway Any process that decreases the rate, frequency or extent of an interleukin-27-mediated signaling pathway. go.json negative regulation of IL-27-mediated signaling pathway|negative regulation of IL27RA/IL6ST signaling pathway|negative regulation of interleukin-27-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070108 GO:0070105 biolink:BiologicalProcess positive regulation of interleukin-6-mediated signaling pathway Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway. go.json positive regulation of IL-6-mediated signaling pathway|positive regulation of interleukin-6-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070105 GO:0070106 biolink:BiologicalProcess interleukin-27-mediated signaling pathway The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-27-mediated signaling pathway|IL27RA/IL6ST signaling pathway|interleukin-27-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070106 GO:0070103 biolink:BiologicalProcess regulation of interleukin-6-mediated signaling pathway Any process that modulates the rate, frequency or extent of an interleukin-6-mediated signaling pathway. go.json regulation of IL-6-mediated signaling pathway|regulation of interleukin-6-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070103 GO:0070104 biolink:BiologicalProcess negative regulation of interleukin-6-mediated signaling pathway Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway. go.json negative regulation of IL-6-mediated signaling pathway|negative regulation of interleukin-6-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070104 GO:0070101 biolink:BiologicalProcess positive regulation of chemokine-mediated signaling pathway Any process that increases the rate, frequency or extent of a chemokine-mediated signaling pathway. go.json positive regulation of chemokine-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070101 GO:0070102 biolink:BiologicalProcess interleukin-6-mediated signaling pathway The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-6-mediated signaling pathway|interleukin-6-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070102 GO:0070100 biolink:BiologicalProcess negative regulation of chemokine-mediated signaling pathway Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway. go.json negative regulation of chemokine-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070100 GO:0070130 biolink:BiologicalProcess negative regulation of mitochondrial translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. go.json negative regulation of mitochondrial protein anabolism|negative regulation of mitochondrial protein biosynthesis|negative regulation of mitochondrial protein formation|negative regulation of mitochondrial protein synthesis http://purl.obolibrary.org/obo/GO_0070130 GO:0045174 biolink:MolecularActivity glutathione dehydrogenase (ascorbate) activity Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide. EC:1.8.5.1|KEGG_REACTION:R01108|MetaCyc:1.8.5.1-RXN|RHEA:24424|Reactome:R-HSA-198813 go.json DHA reductase activity|GDOR|dehydroascorbate reductase activity|dehydroascorbic acid reductase activity|dehydroascorbic reductase activity|glutathione dehydroascorbate reductase activity|glutathione:dehydroascorbate oxidoreductase activity|glutathione:dehydroascorbic acid oxidoreductase activity http://purl.obolibrary.org/obo/GO_0045174 GO:0045175 biolink:BiologicalProcess basal protein localization Any process in which a protein is transported to, or maintained in, basal regions of the cell. go.json basal protein localisation|establishment and maintenance of basal protein localization|establishment and maintenance of protein localization in basal part of cell http://purl.obolibrary.org/obo/GO_0045175 GO:0070131 biolink:BiologicalProcess positive regulation of mitochondrial translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. go.json positive regulation of mitochondrial protein anabolism|positive regulation of mitochondrial protein biosynthesis|positive regulation of mitochondrial protein formation|positive regulation of mitochondrial protein synthesis http://purl.obolibrary.org/obo/GO_0070131 GO:0045172 biolink:CellularComponent germline ring canal Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells. go.json http://purl.obolibrary.org/obo/GO_0045172 GO:0045173 biolink:BiologicalProcess O-sialoglycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities. go.json O-sialoglycoprotein breakdown|O-sialoglycoprotein catabolism|O-sialoglycoprotein degradation http://purl.obolibrary.org/obo/GO_0045173 GO:0045170 biolink:CellularComponent spectrosome A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome. go.json http://purl.obolibrary.org/obo/GO_0045170 GO:0045171 biolink:CellularComponent intercellular bridge A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. go.json http://purl.obolibrary.org/obo/GO_0045171 GO:1901668 biolink:BiologicalProcess regulation of superoxide dismutase activity Any process that modulates the frequency, rate or extent of superoxide dismutase activity. go.json regulation of Cu,Zn-SOD|regulation of Cu-Zn superoxide dismutase activity|regulation of Fe-SOD|regulation of Mn, Fe superoxide dismutase|regulation of Mn-SOD|regulation of SOD|regulation of SOD-1|regulation of SOD-2|regulation of SOD-3|regulation of SOD-4|regulation of SODF|regulation of SODS|regulation of copper, zinc superoxide dismutase activity|regulation of cuprein|regulation of cytocuprein|regulation of erythrocuprein|regulation of ferrisuperoxide dismutase activity|regulation of hemocuprein|regulation of hepatocuprein|regulation of iron superoxide dismutase activity|regulation of iron superoxide oxidoreductase|regulation of manganese superoxide dismutase activity|regulation of manganese superoxide oxidoreductase|regulation of nickel superoxide dismutase activity|regulation of nickel superoxide oxidoreductase|regulation of superoxide dismutase I|regulation of superoxide dismutase II|regulation of superoxide:superoxide oxidoreductase activity|regulation of zinc superoxide oxidoreductase http://purl.obolibrary.org/obo/GO_1901668 gocheck_do_not_annotate GO:1901666 biolink:BiologicalProcess positive regulation of NAD+ ADP-ribosyltransferase activity Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. go.json activation of ADP-ribosyltransferase (polymerizing) activity|activation of NAD ADP-ribosyltransferase activity|activation of NAD+ ADP-ribosyltransferase activity|activation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|activation of poly(ADP-ribose) synthase activity|activation of poly(ADP-ribose) synthetase activity|activation of poly(ADP-ribose)polymerase activity|activation of poly(adenosine diphosphate ribose) polymerase activity|positive regulation of ADP-ribosyltransferase (polymerizing) activity|positive regulation of NAD ADP-ribosyltransferase activity|positive regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|positive regulation of poly(ADP-ribose) synthase activity|positive regulation of poly(ADP-ribose) synthetase activity|positive regulation of poly(ADP-ribose)polymerase activity|positive regulation of poly(adenosine diphosphate ribose) polymerase activity|up regulation of ADP-ribosyltransferase (polymerizing) activity|up regulation of NAD ADP-ribosyltransferase activity|up regulation of NAD+ ADP-ribosyltransferase activity|up regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|up regulation of poly(ADP-ribose) synthase activity|up regulation of poly(ADP-ribose) synthetase activity|up regulation of poly(ADP-ribose)polymerase activity|up regulation of poly(adenosine diphosphate ribose) polymerase activity|up-regulation of ADP-ribosyltransferase (polymerizing) activity|up-regulation of NAD ADP-ribosyltransferase activity|up-regulation of NAD+ ADP-ribosyltransferase activity|up-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|up-regulation of poly(ADP-ribose) synthase activity|up-regulation of poly(ADP-ribose) synthetase activity|up-regulation of poly(ADP-ribose)polymerase activity|up-regulation of poly(adenosine diphosphate ribose) polymerase activity|upregulation of ADP-ribosyltransferase (polymerizing) activity|upregulation of NAD ADP-ribosyltransferase activity|upregulation of NAD+ ADP-ribosyltransferase activity|upregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|upregulation of poly(ADP-ribose) synthase activity|upregulation of poly(ADP-ribose) synthetase activity|upregulation of poly(ADP-ribose)polymerase activity|upregulation of poly(adenosine diphosphate ribose) polymerase activity http://purl.obolibrary.org/obo/GO_1901666 gocheck_do_not_annotate GO:1901667 biolink:BiologicalProcess negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration. go.json down regulation of satellite cell activation involved in skeletal muscle regeneration|down-regulation of satellite cell activation involved in skeletal muscle regeneration|downregulation of satellite cell activation involved in skeletal muscle regeneration|inhibition of satellite cell activation involved in skeletal muscle regeneration http://purl.obolibrary.org/obo/GO_1901667 GO:1901664 biolink:BiologicalProcess regulation of NAD+ ADP-ribosyltransferase activity Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. go.json regulation of ADP-ribosyltransferase (polymerizing) activity|regulation of NAD ADP-ribosyltransferase activity|regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|regulation of poly(ADP-ribose) synthase activity|regulation of poly(ADP-ribose) synthetase activity|regulation of poly(ADP-ribose)polymerase activity|regulation of poly(adenosine diphosphate ribose) polymerase activity http://purl.obolibrary.org/obo/GO_1901664 gocheck_do_not_annotate GO:1901665 biolink:BiologicalProcess negative regulation of NAD+ ADP-ribosyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. go.json down regulation of ADP-ribosyltransferase (polymerizing) activity|down regulation of NAD ADP-ribosyltransferase activity|down regulation of NAD+ ADP-ribosyltransferase activity|down regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|down regulation of poly(ADP-ribose) synthase activity|down regulation of poly(ADP-ribose) synthetase activity|down regulation of poly(ADP-ribose)polymerase activity|down regulation of poly(adenosine diphosphate ribose) polymerase activity|down-regulation of ADP-ribosyltransferase (polymerizing) activity|down-regulation of NAD ADP-ribosyltransferase activity|down-regulation of NAD+ ADP-ribosyltransferase activity|down-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|down-regulation of poly(ADP-ribose) synthase activity|down-regulation of poly(ADP-ribose) synthetase activity|down-regulation of poly(ADP-ribose)polymerase activity|down-regulation of poly(adenosine diphosphate ribose) polymerase activity|downregulation of ADP-ribosyltransferase (polymerizing) activity|downregulation of NAD ADP-ribosyltransferase activity|downregulation of NAD+ ADP-ribosyltransferase activity|downregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|downregulation of poly(ADP-ribose) synthase activity|downregulation of poly(ADP-ribose) synthetase activity|downregulation of poly(ADP-ribose)polymerase activity|downregulation of poly(adenosine diphosphate ribose) polymerase activity|inhibition of ADP-ribosyltransferase (polymerizing) activity|inhibition of NAD ADP-ribosyltransferase activity|inhibition of NAD+ ADP-ribosyltransferase activity|inhibition of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|inhibition of poly(ADP-ribose) synthase activity|inhibition of poly(ADP-ribose) synthetase activity|inhibition of poly(ADP-ribose)polymerase activity|inhibition of poly(adenosine diphosphate ribose) polymerase activity|negative regulation of ADP-ribosyltransferase (polymerizing) activity|negative regulation of NAD ADP-ribosyltransferase activity|negative regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|negative regulation of poly(ADP-ribose) synthase activity|negative regulation of poly(ADP-ribose) synthetase activity|negative regulation of poly(ADP-ribose)polymerase activity|negative regulation of poly(adenosine diphosphate ribose) polymerase activity http://purl.obolibrary.org/obo/GO_1901665 gocheck_do_not_annotate GO:1901662 biolink:BiologicalProcess quinone catabolic process The chemical reactions and pathways resulting in the breakdown of quinone. go.json quinone breakdown|quinone catabolism|quinone cofactor breakdown|quinone cofactor catabolic process|quinone cofactor catabolism|quinone cofactor degradation|quinone degradation http://purl.obolibrary.org/obo/GO_1901662 GO:0045178 biolink:CellularComponent basal part of cell The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. go.json http://purl.obolibrary.org/obo/GO_0045178 goslim_pir GO:1901663 biolink:BiologicalProcess quinone biosynthetic process The chemical reactions and pathways resulting in the formation of quinone. go.json quinone anabolism|quinone biosynthesis|quinone cofactor anabolism|quinone cofactor biosynthesis|quinone cofactor biosynthetic process|quinone cofactor formation|quinone cofactor synthesis|quinone formation|quinone synthesis http://purl.obolibrary.org/obo/GO_1901663 GO:0045179 biolink:CellularComponent apical cortex The region that lies just beneath the plasma membrane on the apical edge of a cell. go.json http://purl.obolibrary.org/obo/GO_0045179 GO:1901660 biolink:BiologicalProcess calcium ion export The directed movement of calcium ion out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_1901660 GO:0045176 biolink:BiologicalProcess apical protein localization Any process in which a protein is transported to, or maintained in, apical regions of the cell. go.json apical protein localisation|establishment and maintenance of apical protein localization|establishment and maintenance of protein localization in apical part of cell http://purl.obolibrary.org/obo/GO_0045176 GO:1901661 biolink:BiologicalProcess quinone metabolic process The chemical reactions and pathways involving quinone. go.json quinone cofactor metabolic process|quinone cofactor metabolism|quinone metabolism http://purl.obolibrary.org/obo/GO_1901661 GO:0045177 biolink:CellularComponent apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. go.json apical region of cell http://purl.obolibrary.org/obo/GO_0045177 goslim_pir GO:1901670 biolink:BiologicalProcess negative regulation of superoxide dismutase activity Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity. go.json down regulation of Cu,Zn-SOD|down regulation of Cu-Zn superoxide dismutase activity|down regulation of Fe-SOD|down regulation of Mn, Fe superoxide dismutase|down regulation of Mn-SOD|down regulation of SOD|down regulation of SOD-1|down regulation of SOD-2|down regulation of SOD-3|down regulation of SOD-4|down regulation of SODF|down regulation of SODS|down regulation of copper, zinc superoxide dismutase activity|down regulation of cuprein|down regulation of cytocuprein|down regulation of erythrocuprein|down regulation of ferrisuperoxide dismutase activity|down regulation of hemocuprein|down regulation of hepatocuprein|down regulation of iron superoxide dismutase activity|down regulation of iron superoxide oxidoreductase|down regulation of manganese superoxide dismutase activity|down regulation of manganese superoxide oxidoreductase|down regulation of nickel superoxide dismutase activity|down regulation of nickel superoxide oxidoreductase|down regulation of superoxide dismutase I|down regulation of superoxide dismutase II|down regulation of superoxide dismutase activity|down regulation of superoxide:superoxide oxidoreductase activity|down regulation of zinc superoxide oxidoreductase|down-regulation of Cu,Zn-SOD|down-regulation of Cu-Zn superoxide dismutase activity|down-regulation of Fe-SOD|down-regulation of Mn, Fe superoxide dismutase|down-regulation of Mn-SOD|down-regulation of SOD|down-regulation of SOD-1|down-regulation of SOD-2|down-regulation of SOD-3|down-regulation of SOD-4|down-regulation of SODF|down-regulation of SODS|down-regulation of copper, zinc superoxide dismutase activity|down-regulation of cuprein|down-regulation of cytocuprein|down-regulation of erythrocuprein|down-regulation of ferrisuperoxide dismutase activity|down-regulation of hemocuprein|down-regulation of hepatocuprein|down-regulation of iron superoxide dismutase activity|down-regulation of iron superoxide oxidoreductase|down-regulation of manganese superoxide dismutase activity|down-regulation of manganese superoxide oxidoreductase|down-regulation of nickel superoxide dismutase activity|down-regulation of nickel superoxide oxidoreductase|down-regulation of superoxide dismutase I|down-regulation of superoxide dismutase II|down-regulation of superoxide dismutase activity|down-regulation of superoxide:superoxide oxidoreductase activity|down-regulation of zinc superoxide oxidoreductase|downregulation of Cu,Zn-SOD|downregulation of Cu-Zn superoxide dismutase activity|downregulation of Fe-SOD|downregulation of Mn, Fe superoxide dismutase|downregulation of Mn-SOD|downregulation of SOD|downregulation of SOD-1|downregulation of SOD-2|downregulation of SOD-3|downregulation of SOD-4|downregulation of SODF|downregulation of SODS|downregulation of copper, zinc superoxide dismutase activity|downregulation of cuprein|downregulation of cytocuprein|downregulation of erythrocuprein|downregulation of ferrisuperoxide dismutase activity|downregulation of hemocuprein|downregulation of hepatocuprein|downregulation of iron superoxide dismutase activity|downregulation of iron superoxide oxidoreductase|downregulation of manganese superoxide dismutase activity|downregulation of manganese superoxide oxidoreductase|downregulation of nickel superoxide dismutase activity|downregulation of nickel superoxide oxidoreductase|downregulation of superoxide dismutase I|downregulation of superoxide dismutase II|downregulation of superoxide dismutase activity|downregulation of superoxide:superoxide oxidoreductase activity|downregulation of zinc superoxide oxidoreductase|inhibition of Cu,Zn-SOD|inhibition of Cu-Zn superoxide dismutase activity|inhibition of Fe-SOD|inhibition of Mn, Fe superoxide dismutase|inhibition of Mn-SOD|inhibition of SOD|inhibition of SOD-1|inhibition of SOD-2|inhibition of SOD-3|inhibition of SOD-4|inhibition of SODF|inhibition of SODS|inhibition of copper, zinc superoxide dismutase activity|inhibition of cuprein|inhibition of cytocuprein|inhibition of erythrocuprein|inhibition of ferrisuperoxide dismutase activity|inhibition of hemocuprein|inhibition of hepatocuprein|inhibition of iron superoxide dismutase activity|inhibition of iron superoxide oxidoreductase|inhibition of manganese superoxide dismutase activity|inhibition of manganese superoxide oxidoreductase|inhibition of nickel superoxide dismutase activity|inhibition of nickel superoxide oxidoreductase|inhibition of superoxide dismutase I|inhibition of superoxide dismutase II|inhibition of superoxide dismutase activity|inhibition of superoxide:superoxide oxidoreductase activity|inhibition of zinc superoxide oxidoreductase|negative regulation of Cu,Zn-SOD|negative regulation of Cu-Zn superoxide dismutase activity|negative regulation of Fe-SOD|negative regulation of Mn, Fe superoxide dismutase|negative regulation of Mn-SOD|negative regulation of SOD|negative regulation of SOD-1|negative regulation of SOD-2|negative regulation of SOD-3|negative regulation of SOD-4|negative regulation of SODF|negative regulation of SODS|negative regulation of copper, zinc superoxide dismutase activity|negative regulation of cuprein|negative regulation of cytocuprein|negative regulation of erythrocuprein|negative regulation of ferrisuperoxide dismutase activity|negative regulation of hemocuprein|negative regulation of hepatocuprein|negative regulation of iron superoxide dismutase activity|negative regulation of iron superoxide oxidoreductase|negative regulation of manganese superoxide dismutase activity|negative regulation of manganese superoxide oxidoreductase|negative regulation of nickel superoxide dismutase activity|negative regulation of nickel superoxide oxidoreductase|negative regulation of superoxide dismutase I|negative regulation of superoxide dismutase II|negative regulation of superoxide:superoxide oxidoreductase activity|negative regulation of zinc superoxide oxidoreductase http://purl.obolibrary.org/obo/GO_1901670 gocheck_do_not_annotate GO:0070138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070138 GO:0070139 biolink:MolecularActivity SUMO-specific endopeptidase activity Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO. Reactome:R-HSA-2990840|Reactome:R-HSA-2990842|Reactome:R-HSA-2993763 go.json http://purl.obolibrary.org/obo/GO_0070139 GO:0070136 biolink:BiologicalProcess beta-1,2-oligomannoside biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan. go.json beta-1,2-oligomannoside anabolism|beta-1,2-oligomannoside biosynthesis|beta-1,2-oligomannoside formation|beta-1,2-oligomannoside synthesis http://purl.obolibrary.org/obo/GO_0070136 GO:0070137 biolink:MolecularActivity ubiquitin-like protein-specific endopeptidase activity Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO). go.json small conjugating protein-specific endopeptidase activity http://purl.obolibrary.org/obo/GO_0070137 GO:0070134 biolink:BiologicalProcess positive regulation of mitochondrial translational initiation Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. go.json positive regulation of mitochondrial translation initiation http://purl.obolibrary.org/obo/GO_0070134 GO:0070135 biolink:BiologicalProcess beta-1,2-oligomannoside metabolic process The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan. go.json beta-1,2-oligomannoside metabolism http://purl.obolibrary.org/obo/GO_0070135 GO:0070132 biolink:BiologicalProcess regulation of mitochondrial translational initiation Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. go.json regulation of mitochondrial translation initiation http://purl.obolibrary.org/obo/GO_0070132 GO:0070133 biolink:BiologicalProcess negative regulation of mitochondrial translational initiation Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. go.json negative regulation of mitochondrial translation initiation http://purl.obolibrary.org/obo/GO_0070133 GO:0045185 biolink:BiologicalProcess maintenance of protein location Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. go.json active protein retrieval|maintenance of protein localization|protein retention|protein sequestering http://purl.obolibrary.org/obo/GO_0045185 GO:0045186 biolink:BiologicalProcess zonula adherens assembly Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0045186 GO:0070120 biolink:BiologicalProcess ciliary neurotrophic factor-mediated signaling pathway The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CNTF-mediated signaling pathway|ciliary neurotrophic factor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070120 GO:0045183 biolink:MolecularActivity translation factor activity, non-nucleic acid binding A translation regulator activity that does not involve binding to nucleic acids. go.json http://purl.obolibrary.org/obo/GO_0045183 GO:0045184 biolink:BiologicalProcess establishment of protein localization The directed movement of a protein to a specific location. go.json establishment of protein localisation|protein positioning|protein recruitment http://purl.obolibrary.org/obo/GO_0045184 GO:0045181 biolink:MolecularActivity glutamate synthase activity, NAD(P)H as acceptor Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. go.json glutamate synthase activity, NADH or NADPH as acceptor http://purl.obolibrary.org/obo/GO_0045181 GO:0045182 biolink:MolecularActivity translation regulator activity Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. go.json translation factor activity http://purl.obolibrary.org/obo/GO_0045182 goslim_candida|goslim_drosophila|goslim_generic|goslim_pir|goslim_plant|prokaryote_subset GO:1901679 biolink:BiologicalProcess nucleotide transmembrane transport The directed movement of nucleotide across a membrane. go.json nucleotide membrane transport http://purl.obolibrary.org/obo/GO_1901679 GO:0045180 biolink:CellularComponent basal cortex The region that lies just beneath the plasma membrane on the basal edge of a cell. go.json http://purl.obolibrary.org/obo/GO_0045180 GO:1901677 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901677 GO:1901678 biolink:BiologicalProcess iron coordination entity transport The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901678 GO:1901675 biolink:BiologicalProcess obsolete negative regulation of histone H3-K27 acetylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation. go.json down regulation of histone H3 acetylation at K27|down regulation of histone H3-K27 acetylation|down regulation of histone H3K27 acetylation|down-regulation of histone H3 acetylation at K27|down-regulation of histone H3-K27 acetylation|down-regulation of histone H3K27 acetylation|downregulation of histone H3 acetylation at K27|downregulation of histone H3-K27 acetylation|downregulation of histone H3K27 acetylation|inhibition of histone H3 acetylation at K27|inhibition of histone H3-K27 acetylation|inhibition of histone H3K27 acetylation|negative regulation of histone H3 acetylation at K27|negative regulation of histone H3K27 acetylation True http://purl.obolibrary.org/obo/GO_1901675 GO:1901676 biolink:BiologicalProcess obsolete positive regulation of histone H3-K27 acetylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation. go.json activation of histone H3 acetylation at K27|activation of histone H3-K27 acetylation|activation of histone H3K27 acetylation|positive regulation of histone H3 acetylation at K27|positive regulation of histone H3K27 acetylation|up regulation of histone H3 acetylation at K27|up regulation of histone H3-K27 acetylation|up regulation of histone H3K27 acetylation|up-regulation of histone H3 acetylation at K27|up-regulation of histone H3-K27 acetylation|up-regulation of histone H3K27 acetylation|upregulation of histone H3 acetylation at K27|upregulation of histone H3-K27 acetylation|upregulation of histone H3K27 acetylation True http://purl.obolibrary.org/obo/GO_1901676 GO:0045189 biolink:BiologicalProcess obsolete connective tissue growth factor biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta. go.json CTGF biosynthesis|connective tissue growth factor anabolism|connective tissue growth factor biosynthesis|connective tissue growth factor formation|connective tissue growth factor synthesis True http://purl.obolibrary.org/obo/GO_0045189 GO:1901673 biolink:BiologicalProcess regulation of mitotic spindle assembly Any process that modulates the frequency, rate or extent of mitotic spindle assembly. go.json regulation of spindle assembly involved in mitosis http://purl.obolibrary.org/obo/GO_1901673 GO:1901674 biolink:BiologicalProcess obsolete regulation of histone H3-K27 acetylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation. go.json regulation of histone H3 acetylation at K27|regulation of histone H3K27 acetylation True http://purl.obolibrary.org/obo/GO_1901674 GO:1901671 biolink:BiologicalProcess positive regulation of superoxide dismutase activity Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity. go.json activation of Cu,Zn-SOD|activation of Cu-Zn superoxide dismutase activity|activation of Fe-SOD|activation of Mn, Fe superoxide dismutase|activation of Mn-SOD|activation of SOD|activation of SOD-1|activation of SOD-2|activation of SOD-3|activation of SOD-4|activation of SODF|activation of SODS|activation of copper, zinc superoxide dismutase activity|activation of cuprein|activation of cytocuprein|activation of erythrocuprein|activation of ferrisuperoxide dismutase activity|activation of hemocuprein|activation of hepatocuprein|activation of iron superoxide dismutase activity|activation of iron superoxide oxidoreductase|activation of manganese superoxide dismutase activity|activation of manganese superoxide oxidoreductase|activation of nickel superoxide dismutase activity|activation of nickel superoxide oxidoreductase|activation of superoxide dismutase I|activation of superoxide dismutase II|activation of superoxide dismutase activity|activation of superoxide:superoxide oxidoreductase activity|activation of zinc superoxide oxidoreductase|positive regulation of Cu,Zn-SOD|positive regulation of Cu-Zn superoxide dismutase activity|positive regulation of Fe-SOD|positive regulation of Mn, Fe superoxide dismutase|positive regulation of Mn-SOD|positive regulation of SOD|positive regulation of SOD-1|positive regulation of SOD-2|positive regulation of SOD-3|positive regulation of SOD-4|positive regulation of SODF|positive regulation of SODS|positive regulation of copper, zinc superoxide dismutase activity|positive regulation of cuprein|positive regulation of cytocuprein|positive regulation of erythrocuprein|positive regulation of ferrisuperoxide dismutase activity|positive regulation of hemocuprein|positive regulation of hepatocuprein|positive regulation of iron superoxide dismutase activity|positive regulation of iron superoxide oxidoreductase|positive regulation of manganese superoxide dismutase activity|positive regulation of manganese superoxide oxidoreductase|positive regulation of nickel superoxide dismutase activity|positive regulation of nickel superoxide oxidoreductase|positive regulation of superoxide dismutase I|positive regulation of superoxide dismutase II|positive regulation of superoxide:superoxide oxidoreductase activity|positive regulation of zinc superoxide oxidoreductase|up regulation of Cu,Zn-SOD|up regulation of Cu-Zn superoxide dismutase activity|up regulation of Fe-SOD|up regulation of Mn, Fe superoxide dismutase|up regulation of Mn-SOD|up regulation of SOD|up regulation of SOD-1|up regulation of SOD-2|up regulation of SOD-3|up regulation of SOD-4|up regulation of SODF|up regulation of SODS|up regulation of copper, zinc superoxide dismutase activity|up regulation of cuprein|up regulation of cytocuprein|up regulation of erythrocuprein|up regulation of ferrisuperoxide dismutase activity|up regulation of hemocuprein|up regulation of hepatocuprein|up regulation of iron superoxide dismutase activity|up regulation of iron superoxide oxidoreductase|up regulation of manganese superoxide dismutase activity|up regulation of manganese superoxide oxidoreductase|up regulation of nickel superoxide dismutase activity|up regulation of nickel superoxide oxidoreductase|up regulation of superoxide dismutase I|up regulation of superoxide dismutase II|up regulation of superoxide dismutase activity|up regulation of superoxide:superoxide oxidoreductase activity|up regulation of zinc superoxide oxidoreductase|up-regulation of Cu,Zn-SOD|up-regulation of Cu-Zn superoxide dismutase activity|up-regulation of Fe-SOD|up-regulation of Mn, Fe superoxide dismutase|up-regulation of Mn-SOD|up-regulation of SOD|up-regulation of SOD-1|up-regulation of SOD-2|up-regulation of SOD-3|up-regulation of SOD-4|up-regulation of SODF|up-regulation of SODS|up-regulation of copper, zinc superoxide dismutase activity|up-regulation of cuprein|up-regulation of cytocuprein|up-regulation of erythrocuprein|up-regulation of ferrisuperoxide dismutase activity|up-regulation of hemocuprein|up-regulation of hepatocuprein|up-regulation of iron superoxide dismutase activity|up-regulation of iron superoxide oxidoreductase|up-regulation of manganese superoxide dismutase activity|up-regulation of manganese superoxide oxidoreductase|up-regulation of nickel superoxide dismutase activity|up-regulation of nickel superoxide oxidoreductase|up-regulation of superoxide dismutase I|up-regulation of superoxide dismutase II|up-regulation of superoxide dismutase activity|up-regulation of superoxide:superoxide oxidoreductase activity|up-regulation of zinc superoxide oxidoreductase|upregulation of Cu,Zn-SOD|upregulation of Cu-Zn superoxide dismutase activity|upregulation of Fe-SOD|upregulation of Mn, Fe superoxide dismutase|upregulation of Mn-SOD|upregulation of SOD|upregulation of SOD-1|upregulation of SOD-2|upregulation of SOD-3|upregulation of SOD-4|upregulation of SODF|upregulation of SODS|upregulation of copper, zinc superoxide dismutase activity|upregulation of cuprein|upregulation of cytocuprein|upregulation of erythrocuprein|upregulation of ferrisuperoxide dismutase activity|upregulation of hemocuprein|upregulation of hepatocuprein|upregulation of iron superoxide dismutase activity|upregulation of iron superoxide oxidoreductase|upregulation of manganese superoxide dismutase activity|upregulation of manganese superoxide oxidoreductase|upregulation of nickel superoxide dismutase activity|upregulation of nickel superoxide oxidoreductase|upregulation of superoxide dismutase I|upregulation of superoxide dismutase II|upregulation of superoxide dismutase activity|upregulation of superoxide:superoxide oxidoreductase activity|upregulation of zinc superoxide oxidoreductase http://purl.obolibrary.org/obo/GO_1901671 gocheck_do_not_annotate GO:0045187 biolink:BiologicalProcess regulation of circadian sleep/wake cycle, sleep Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. go.json regulation of sleep http://purl.obolibrary.org/obo/GO_0045187 GO:0045188 biolink:BiologicalProcess regulation of circadian sleep/wake cycle, non-REM sleep Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. go.json regulation of non-REM sleep http://purl.obolibrary.org/obo/GO_0045188 GO:1901672 biolink:BiologicalProcess positive regulation of systemic acquired resistance Any process that activates or increases the frequency, rate or extent of systemic acquired resistance. go.json activation of salicylic acid-dependent systemic resistance|activation of systemic acquired resistance|positive regulation of salicylic acid-dependent systemic resistance|up regulation of salicylic acid-dependent systemic resistance|up regulation of systemic acquired resistance|up-regulation of salicylic acid-dependent systemic resistance|up-regulation of systemic acquired resistance|upregulation of salicylic acid-dependent systemic resistance|upregulation of systemic acquired resistance http://purl.obolibrary.org/obo/GO_1901672 GO:1901680 biolink:MolecularActivity sulfur-containing amino acid secondary active transmembrane transporter activity Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json http://purl.obolibrary.org/obo/GO_1901680 GO:1901681 biolink:MolecularActivity sulfur compound binding Binding to a sulfur compound. go.json sulfur molecular entity binding http://purl.obolibrary.org/obo/GO_1901681 GO:0070129 biolink:BiologicalProcess regulation of mitochondrial translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. go.json regulation of mitochondrial protein anabolism|regulation of mitochondrial protein biosynthesis|regulation of mitochondrial protein formation|regulation of mitochondrial protein synthesis http://purl.obolibrary.org/obo/GO_0070129 GO:0070127 biolink:BiologicalProcess tRNA aminoacylation for mitochondrial protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0070127 GO:0070128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070128 GO:0070125 biolink:BiologicalProcess mitochondrial translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion. go.json mitochondrial translation elongation http://purl.obolibrary.org/obo/GO_0070125 GO:0070126 biolink:BiologicalProcess mitochondrial translational termination The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa). go.json mitochondrial translation termination http://purl.obolibrary.org/obo/GO_0070126 GO:0070123 biolink:MolecularActivity transforming growth factor beta receptor activity, type III Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. go.json betaglycan|endoglin|transforming growth factor beta ligand binding to type III receptor|type III TGF-beta receptor activity|type III TGFbeta receptor activity|type III transforming growth factor beta receptor activity http://purl.obolibrary.org/obo/GO_0070123 GO:0070124 biolink:BiologicalProcess mitochondrial translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. go.json mitochondrial translation initiation http://purl.obolibrary.org/obo/GO_0070124 GO:0070121 biolink:BiologicalProcess Kupffer's vesicle development The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period. go.json KV development http://purl.obolibrary.org/obo/GO_0070121 GO:0070122 biolink:MolecularActivity obsolete isopeptidase activity OBSOLETE. Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond). go.json True http://purl.obolibrary.org/obo/GO_0070122 GO:0060908 biolink:BiologicalProcess plasmid copy number maintenance The maintenance of the number of copies of extrachromosomal plasmid DNA. go.json http://purl.obolibrary.org/obo/GO_0060908 GO:0060909 biolink:BiologicalProcess regulation of DNA replication initiation involved in plasmid copy number maintenance Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. go.json http://purl.obolibrary.org/obo/GO_0060909 GO:0035944 biolink:BiologicalProcess perforin production The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0035944 gocheck_do_not_annotate GO:0035945 biolink:BiologicalProcess mitochondrial ncRNA surveillance The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion. go.json mitochondrial aberrant ncRNA catabolic process|mitochondrial ncRNA quality control|mitochondrial non-coding RNA surveillance http://purl.obolibrary.org/obo/GO_0035945 GO:0035946 biolink:BiologicalProcess mitochondrial mRNA surveillance The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion. go.json mitochondrial aberrant RNA catabolic process|mitochondrial mRNA quality control|mitochondrial messenger RNA surveillance http://purl.obolibrary.org/obo/GO_0035946 GO:0035947 biolink:BiologicalProcess obsolete regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter. go.json regulation of gluconeogenesis by regulation of transcription from Pol II promoter|regulation of glucose biosynthesis by regulation of transcription from Pol II promoter|regulation of glucose biosynthesis by regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthetic process by regulation of transcription from Pol II promoter|regulation of glucose biosynthetic process by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035947 GO:0035948 biolink:BiologicalProcess obsolete positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of gluconeogenesis by activation of transcription from RNA polymerase II promoter|regulation of gluconeogenesis by positive regulation of transcription from Pol II promoter|regulation of gluconeogenesis by stimulation of transcription from RNA polymerase II promoter|regulation of gluconeogenesis by up regulation of transcription from RNA polymerase II promoter|regulation of gluconeogenesis by up-regulation of transcription from RNA polymerase II promoter|regulation of gluconeogenesis by upregulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthesis by positive regulation of transcription from Pol II promoter|regulation of glucose biosynthesis by positive regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthesis by up regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthesis by up-regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthesis by upregulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthetic process by positive regulation of transcription from Pol II promoter|regulation of glucose biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthetic process by up regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthetic process by up-regulation of transcription from RNA polymerase II promoter|regulation of glucose biosynthetic process by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035948 GO:0035949 biolink:BiologicalProcess obsolete positive regulation of gluconeogenesis by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of gluconeogenesis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of gluconeogenesis by down regulation of transcription from RNA polymerase II promoter|positive regulation of gluconeogenesis by down-regulation of transcription from RNA polymerase II promoter|positive regulation of gluconeogenesis by downregulation of transcription from RNA polymerase II promoter|positive regulation of gluconeogenesis by inhibition of transcription from RNA polymerase II promoter|positive regulation of gluconeogenesis by negative regulation of transcription from Pol II promoter|positive regulation of glucose biosynthesis by down regulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthesis by down-regulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthesis by downregulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthesis by negative regulation of transcription from Pol II promoter|positive regulation of glucose biosynthesis by negative regulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthetic process by down regulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthetic process by down-regulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthetic process by downregulation of transcription from RNA polymerase II promoter|positive regulation of glucose biosynthetic process by negative regulation of transcription from Pol II promoter|positive regulation of glucose biosynthetic process by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035949 GO:0035940 biolink:BiologicalProcess obsolete negative regulation of peptidase activity in other organism OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism. go.json down regulation of peptidase activity in other organism|down-regulation of protease activity in other organism|downregulation of peptidase activity in other organism|inhibition of protease activity in other organism|negative regulation of protease activity in other organism True http://purl.obolibrary.org/obo/GO_0035940 GO:0035941 biolink:BiologicalProcess androstenedione secretion The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system. go.json androst-4-ene-3,17-dione secretion http://purl.obolibrary.org/obo/GO_0035941 GO:0035942 biolink:BiologicalProcess dehydroepiandrosterone secretion The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system. go.json 3beta-hydroxyandrost-5-en-17-one secretion|DHEA secretion|dehydroisoandrosterone secretion http://purl.obolibrary.org/obo/GO_0035942 GO:0060910 biolink:BiologicalProcess negative regulation of DNA replication initiation involved in plasmid copy number maintenance Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. go.json http://purl.obolibrary.org/obo/GO_0060910 GO:0035943 biolink:BiologicalProcess estrone secretion The regulated release of estrone into the circulatory system. go.json 3-hydroxy-1,3,5(10)-estratrien-17-one secretion|folliculin secretion http://purl.obolibrary.org/obo/GO_0035943 GO:0060911 biolink:BiologicalProcess cardiac cell fate commitment The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. go.json cardiocyte cell fate commitment http://purl.obolibrary.org/obo/GO_0060911 GO:0060912 biolink:BiologicalProcess cardiac cell fate specification The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. go.json cardiocyte cell fate specification http://purl.obolibrary.org/obo/GO_0060912 GO:0060913 biolink:BiologicalProcess cardiac cell fate determination The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. go.json cardiocyte cell fate determination http://purl.obolibrary.org/obo/GO_0060913 GO:0060914 biolink:BiologicalProcess heart formation The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. go.json cardiogenesis http://purl.obolibrary.org/obo/GO_0060914 GO:0060915 biolink:BiologicalProcess mesenchymal cell differentiation involved in lung development The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. go.json http://purl.obolibrary.org/obo/GO_0060915 GO:0060916 biolink:BiologicalProcess mesenchymal cell proliferation involved in lung development The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json http://purl.obolibrary.org/obo/GO_0060916 GO:0060917 biolink:BiologicalProcess regulation of (1->6)-beta-D-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans. go.json regulation of 1,6-beta-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0060917 GO:0060918 biolink:BiologicalProcess auxin transport The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Auxins are a group of plant hormones that regulates aspects of plant growth. go.json http://purl.obolibrary.org/obo/GO_0060918 GO:0035933 biolink:BiologicalProcess glucocorticoid secretion The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood. go.json http://purl.obolibrary.org/obo/GO_0035933 GO:0035934 biolink:BiologicalProcess corticosterone secretion The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. go.json http://purl.obolibrary.org/obo/GO_0035934 GO:0035935 biolink:BiologicalProcess androgen secretion The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. go.json http://purl.obolibrary.org/obo/GO_0035935 GO:0035936 biolink:BiologicalProcess testosterone secretion The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. go.json http://purl.obolibrary.org/obo/GO_0035936 GO:0035937 biolink:BiologicalProcess estrogen secretion The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals. go.json oestrogen secretion http://purl.obolibrary.org/obo/GO_0035937 GO:0035938 biolink:BiologicalProcess estradiol secretion The regulated release of estradiol into the circulatory system. go.json oestradiol secretion http://purl.obolibrary.org/obo/GO_0035938 GO:0035939 biolink:MolecularActivity microsatellite binding Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem. go.json VNTR binding|microsatellite DNA binding|variable number tandem repeat binding http://purl.obolibrary.org/obo/GO_0035939 GO:0035930 biolink:BiologicalProcess corticosteroid hormone secretion The regulated release of any corticosteroid hormone into the circulatory system. go.json corticosteroid secretion http://purl.obolibrary.org/obo/GO_0035930 GO:0035931 biolink:BiologicalProcess mineralocorticoid secretion The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism. go.json http://purl.obolibrary.org/obo/GO_0035931 GO:0035932 biolink:BiologicalProcess aldosterone secretion The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. go.json http://purl.obolibrary.org/obo/GO_0035932 GO:0060900 biolink:BiologicalProcess embryonic camera-type eye formation The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. go.json http://purl.obolibrary.org/obo/GO_0060900 GO:0060901 biolink:BiologicalProcess regulation of hair cycle by canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle. go.json regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin|regulation of hair cycle by canonical Wnt receptor signaling pathway|regulation of hair cycle by canonical Wnt receptor signalling pathway|regulation of hair cycle by canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0060901 GO:0060902 biolink:BiologicalProcess obsolete regulation of hair cycle by BMP signaling pathway OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle. go.json regulation of hair cycle by BMP signalling pathway True http://purl.obolibrary.org/obo/GO_0060902 GO:0060903 biolink:BiologicalProcess positive regulation of meiosis I Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. go.json http://purl.obolibrary.org/obo/GO_0060903 GO:0060904 biolink:BiologicalProcess regulation of protein folding in endoplasmic reticulum Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). go.json http://purl.obolibrary.org/obo/GO_0060904 GO:0060905 biolink:BiologicalProcess regulation of induction of conjugation upon nitrogen starvation Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation. go.json http://purl.obolibrary.org/obo/GO_0060905 GO:0060906 biolink:BiologicalProcess negative regulation of regulatory ncRNA-mediated heterochromatin formation Any process that decreases the frequency, rate or extent of non-coding RNA-mediated heterochromatin formation. go.json negative regulation of RNAi-mediated heterochromatin assembly|negative regulation of chromatin silencing by small RNA|negative regulation of heterochromatin assembly by small RNA|negative regulation of ncRNA-mediated heterochromatin formation|negative regulation of small non-coding RNA-mediated heterochromatin formation http://purl.obolibrary.org/obo/GO_0060906 GO:0060907 biolink:BiologicalProcess positive regulation of macrophage cytokine production Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0060907 GO:0035922 biolink:BiologicalProcess foramen ovale closure The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow. go.json foramen ovale of heart closure http://purl.obolibrary.org/obo/GO_0035922 GO:0035923 biolink:MolecularActivity flurbiprofen binding Binding to flurbiprofen. go.json 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding http://purl.obolibrary.org/obo/GO_0035923 GO:0035924 biolink:BiologicalProcess cellular response to vascular endothelial growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. go.json cellular response to VEGF|cellular response to VEGFA|cellular response to VEGFB|cellular response to vascular endothelial growth factor http://purl.obolibrary.org/obo/GO_0035924 GO:0035925 biolink:MolecularActivity mRNA 3'-UTR AU-rich region binding Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. go.json ARE binding|AU-rich element binding|adenylate/uridylate-rich element binding|mRNA 3'-UTR adenylate/uridylate-rich element binding http://purl.obolibrary.org/obo/GO_0035925 GO:0035926 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035926 GO:0035927 biolink:BiologicalProcess RNA import into mitochondrion The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix. go.json cytoplasmic RNA import into mitochondrion|nuclear-encoded RNA import into mitochondrion http://purl.obolibrary.org/obo/GO_0035927 GO:0035928 biolink:BiologicalProcess rRNA import into mitochondrion The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix. go.json cytoplasmic rRNA import into mitochondrion|nuclear-encoded rRNA import into mitochondrion http://purl.obolibrary.org/obo/GO_0035928 GO:0035929 biolink:BiologicalProcess steroid hormone secretion The regulated release of any steroid that acts as a hormone into the circulatory system. go.json http://purl.obolibrary.org/obo/GO_0035929 GO:0060930 biolink:BiologicalProcess sinoatrial node cell fate commitment The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node. go.json SA node cell commitment|SAN cell commitment|sinus node cell commitment http://purl.obolibrary.org/obo/GO_0060930 GO:0060931 biolink:BiologicalProcess sinoatrial node cell development The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. go.json SA node cell development|SAN cell development|sinus node cell development http://purl.obolibrary.org/obo/GO_0060931 GO:0035920 biolink:BiologicalProcess negative regulation of high voltage-gated calcium channel activity in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. go.json down-regulation of high voltage-gated calcium channel activity in other organism|downregulation of high voltage-gated calcium channel activity in other organism|inhibition of high voltage-gated calcium channel activity in other organism|negative regulation of high voltage gated calcium channel activity in other organism|negative regulation of high voltage-dependent calcium channel activity in other organism|negative regulation of high voltage-gated calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0035920 GO:0035921 biolink:BiologicalProcess desmosome disassembly The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. go.json desmosome dissociation http://purl.obolibrary.org/obo/GO_0035921 GO:0060932 biolink:BiologicalProcess His-Purkinje system cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. go.json http://purl.obolibrary.org/obo/GO_0060932 GO:0060933 biolink:BiologicalProcess His-Purkinje system cell development The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. go.json http://purl.obolibrary.org/obo/GO_0060933 GO:0060934 biolink:BiologicalProcess His-Purkinje system cell fate commitment The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. go.json http://purl.obolibrary.org/obo/GO_0060934 GO:0060935 biolink:BiologicalProcess cardiac fibroblast cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060935 GO:0060936 biolink:BiologicalProcess cardiac fibroblast cell development The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060936 GO:0060937 biolink:BiologicalProcess cardiac fibroblast cell fate commitment The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060937 GO:0060938 biolink:BiologicalProcess epicardium-derived cardiac fibroblast cell differentiation The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060938 GO:0060939 biolink:BiologicalProcess epicardium-derived cardiac fibroblast cell development The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060939 GO:0035919 biolink:BiologicalProcess negative regulation of low voltage-gated calcium channel activity in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. go.json down-regulation of low voltage-gated calcium channel activity in other organism|downregulation of low voltage-gated calcium channel activity in other organism|inhibition of low voltage-gated calcium channel activity in other organism|negative regulation of low voltage gated calcium channel activity in other organism|negative regulation of low voltage-dependent calcium channel activity in other organism|negative regulation of low voltage-gated calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0035919 GO:0060919 biolink:BiologicalProcess auxin import into cell The directed movement of auxins from outside of a cell into a cell. go.json auxin influx http://purl.obolibrary.org/obo/GO_0060919 GO:0035911 biolink:BiologicalProcess descending aorta morphogenesis The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035911 GO:0045303 biolink:MolecularActivity diaminobutyrate-2-oxoglutarate transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate. EC:2.6.1.76|KEGG_REACTION:R06977|MetaCyc:R101-RXN|RHEA:11160 go.json 2,4-diaminobutyrate 4-aminotransferase activity|DAB aminotransferase activity|DABA aminotransferase activity|EctB|L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity|L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity|L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity|diaminibutyric acid aminotransferase activity|diaminobutyrate transaminase activity|diaminobutyrate--2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0045303 GO:0045304 biolink:BiologicalProcess regulation of establishment of competence for transformation Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome. go.json regulator of establishment of competence for transformation activity http://purl.obolibrary.org/obo/GO_0045304 GO:0035912 biolink:BiologicalProcess dorsal aorta morphogenesis The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035912 GO:0045301 biolink:MolecularActivity tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin. go.json 2-methylthio-cis-ribozeatin hydroxylase activity|tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity|tRNA-(ms2io6A)-hydroxylase activity http://purl.obolibrary.org/obo/GO_0045301 GO:0035913 biolink:BiologicalProcess ventral aorta morphogenesis The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035913 GO:0045302 biolink:MolecularActivity choloylglycine hydrolase activity Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine. EC:3.5.1.24|MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN|RHEA:19353 go.json 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity|bile salt hydrolase activity|choloyltaurine hydrolase activity|glycocholase activity http://purl.obolibrary.org/obo/GO_0045302 GO:0035914 biolink:BiologicalProcess skeletal muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. go.json http://purl.obolibrary.org/obo/GO_0035914 GO:0035915 biolink:BiologicalProcess pore formation in membrane of another organism The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism. go.json pore complex assembly in other organism|pore complex biogenesis in other organism|pore formation in membrane of other organism|pore formation in other organism|pore-forming toxin activity http://purl.obolibrary.org/obo/GO_0035915 GO:0035916 biolink:BiologicalProcess modulation of calcium channel activity in another organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism. go.json modulation of calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0035916 GO:0045300 biolink:MolecularActivity acyl-[acyl-carrier-protein] desaturase activity Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. EC:1.14.19.2|MetaCyc:RXN-7903 go.json acyl-[acyl-carrier protein] desaturase activity|acyl-acyl-carrier-protein desaturase activity|acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity|stearyl acyl carrier protein desaturase activity|stearyl-ACP desaturase activity http://purl.obolibrary.org/obo/GO_0045300 GO:0035917 biolink:BiologicalProcess negative regulation of calcium channel activity in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism. go.json down-regulation of calcium channel activity in other organism|downregulation of calcium channel activity in other organism|inhibition of calcium channel activity in other organism|negative regulation of calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0035917 GO:0035918 biolink:BiologicalProcess negative regulation of voltage-gated calcium channel activity in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json down-regulation of voltage-gated calcium channel activity in other organism|downregulation of voltage-gated calcium channel activity in other organism|inhibition of voltage-gated calcium channel activity in other organism|negative regulation of voltage gated calcium channel activity in other organism|negative regulation of voltage-dependent calcium channel activity in other organism|negative regulation of voltage-gated calcium channel activity in other organism|negative regulation of voltage-sensitive calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0035918 GO:0045309 biolink:MolecularActivity protein phosphorylated amino acid binding Binding to a phosphorylated amino acid residue within a protein. go.json phosphoprotein amino acid binding http://purl.obolibrary.org/obo/GO_0045309 GO:0045307 biolink:MolecularActivity obsolete activator of the establishment of competence for transformation activity OBSOLETE. Activates the establishment of competence for transformation. go.json activator of the establishment of competence for transformation activity True http://purl.obolibrary.org/obo/GO_0045307 GO:0045308 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045308 GO:0045305 biolink:MolecularActivity obsolete regulator of establishment of competence for transformation activity OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation. go.json regulator of establishment of competence for transformation activity True http://purl.obolibrary.org/obo/GO_0045305 GO:0060920 biolink:BiologicalProcess cardiac pacemaker cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. go.json pacemaker cell differentiation http://purl.obolibrary.org/obo/GO_0060920 GO:0045306 biolink:MolecularActivity obsolete inhibitor of the establishment of competence for transformation activity OBSOLETE. Inhibits the establishment of competence for transformation. go.json inhibitor of the establishment of competence for transformation activity True http://purl.obolibrary.org/obo/GO_0045306 GO:0060921 biolink:BiologicalProcess sinoatrial node cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. go.json SA node cell differentiation|SAN cell differentiation|sinus node cell differentiation http://purl.obolibrary.org/obo/GO_0060921 GO:0035910 biolink:BiologicalProcess ascending aorta morphogenesis The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035910 GO:0060922 biolink:BiologicalProcess atrioventricular node cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. go.json AV node cell differentiation http://purl.obolibrary.org/obo/GO_0060922 GO:0060923 biolink:BiologicalProcess cardiac muscle cell fate commitment The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. go.json cardiomyocyte cell fate commitment|heart muscle cell fate commitment http://purl.obolibrary.org/obo/GO_0060923 GO:0060924 biolink:BiologicalProcess atrial cardiac muscle cell fate commitment The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. go.json atrial cardiomyocyte cell fate commitment|atrial heart muscle cell fate commitment http://purl.obolibrary.org/obo/GO_0060924 GO:0060925 biolink:BiologicalProcess ventricular cardiac muscle cell fate commitment The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. go.json ventricular cardiomyocyte cell fate commitment|ventricular heart muscle cell fate commitment http://purl.obolibrary.org/obo/GO_0060925 GO:0060926 biolink:BiologicalProcess cardiac pacemaker cell development The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. go.json pacemaker cell development http://purl.obolibrary.org/obo/GO_0060926 GO:0060927 biolink:BiologicalProcess cardiac pacemaker cell fate commitment The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. go.json pacemaker cell fate commitment http://purl.obolibrary.org/obo/GO_0060927 GO:0060928 biolink:BiologicalProcess atrioventricular node cell development The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. go.json AV node cell development http://purl.obolibrary.org/obo/GO_0060928 GO:0060929 biolink:BiologicalProcess atrioventricular node cell fate commitment The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells. go.json AV node cell fate commitment http://purl.obolibrary.org/obo/GO_0060929 GO:0035908 biolink:BiologicalProcess ventral aorta development The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035908 GO:0035909 biolink:BiologicalProcess aorta morphogenesis The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. go.json http://purl.obolibrary.org/obo/GO_0035909 GO:0035900 biolink:BiologicalProcess response to isolation stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. go.json response to social isolation http://purl.obolibrary.org/obo/GO_0035900 GO:0045314 biolink:BiologicalProcess regulation of compound eye photoreceptor development Any process that modulates the frequency, rate or extent of compound eye photoreceptor development. go.json regulation of eye photoreceptor development http://purl.obolibrary.org/obo/GO_0045314 GO:0035901 biolink:BiologicalProcess cellular response to isolation stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. go.json cellular response to social isolation http://purl.obolibrary.org/obo/GO_0035901 GO:0045315 biolink:BiologicalProcess positive regulation of compound eye photoreceptor development Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development. go.json activation of eye photoreceptor development|positive regulation of eye photoreceptor development|stimulation of eye photoreceptor development|up regulation of eye photoreceptor development|up-regulation of eye photoreceptor development|upregulation of eye photoreceptor development http://purl.obolibrary.org/obo/GO_0045315 GO:0035902 biolink:BiologicalProcess response to immobilization stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. go.json response to immobilisation stress|response to restraint stress http://purl.obolibrary.org/obo/GO_0035902 GO:0045312 biolink:BiologicalProcess nor-spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. go.json nor-spermidine anabolism|nor-spermidine biosynthesis|nor-spermidine formation|nor-spermidine synthesis http://purl.obolibrary.org/obo/GO_0045312 GO:0045313 biolink:BiologicalProcess rhabdomere membrane biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane. go.json http://purl.obolibrary.org/obo/GO_0045313 GO:0035903 biolink:BiologicalProcess cellular response to immobilization stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. go.json cellular response to immobilisation stress|cellular response to restraint stress http://purl.obolibrary.org/obo/GO_0035903 GO:0045310 biolink:MolecularActivity obsolete phosphoserine/phosphothreonine binding OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein. go.json phosphoserine/phosphothreonine binding True http://purl.obolibrary.org/obo/GO_0045310 GO:0035904 biolink:BiologicalProcess aorta development The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. go.json http://purl.obolibrary.org/obo/GO_0035904 GO:0035905 biolink:BiologicalProcess ascending aorta development The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035905 GO:0045311 biolink:BiologicalProcess invasive growth in response to pheromone The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus. go.json http://purl.obolibrary.org/obo/GO_0045311 GO:0035906 biolink:BiologicalProcess descending aorta development The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035906 GO:0035907 biolink:BiologicalProcess dorsal aorta development The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. go.json http://purl.obolibrary.org/obo/GO_0035907 GO:0060950 biolink:BiologicalProcess cardiac glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. go.json http://purl.obolibrary.org/obo/GO_0060950 GO:0060951 biolink:BiologicalProcess neural crest-derived cardiac glial cell differentiation The process in which a neural crest cell acquires the specialized features of a glial cell of the heart. go.json http://purl.obolibrary.org/obo/GO_0060951 GO:0045318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045318 GO:0060952 biolink:BiologicalProcess cardiac glial cell development The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. go.json http://purl.obolibrary.org/obo/GO_0060952 GO:0045319 biolink:BiologicalProcess obsolete SRP-independent cotranslational protein-membrane targeting, translocation OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition. go.json SRP-independent cotranslational membrane targeting, translocation|SRP-independent cotranslational protein-membrane targeting, translocation True http://purl.obolibrary.org/obo/GO_0045319 GO:0060953 biolink:BiologicalProcess cardiac glial cell fate commitment The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. go.json http://purl.obolibrary.org/obo/GO_0060953 GO:0045316 biolink:BiologicalProcess negative regulation of compound eye photoreceptor development Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development. go.json down regulation of eye photoreceptor development|down-regulation of eye photoreceptor development|downregulation of eye photoreceptor development|inhibition of eye photoreceptor development|negative regulation of eye photoreceptor development http://purl.obolibrary.org/obo/GO_0045316 GO:0060954 biolink:BiologicalProcess neural crest-derived cardiac glial cell development The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0060954 GO:0045317 biolink:BiologicalProcess equator specification The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves. go.json http://purl.obolibrary.org/obo/GO_0045317 GO:0060955 biolink:BiologicalProcess neural crest-derived cardiac glial cell fate commitment The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. go.json http://purl.obolibrary.org/obo/GO_0060955 GO:0060956 biolink:BiologicalProcess endocardial cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. go.json http://purl.obolibrary.org/obo/GO_0060956 GO:0060957 biolink:BiologicalProcess endocardial cell fate commitment The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. go.json http://purl.obolibrary.org/obo/GO_0060957 GO:0060958 biolink:BiologicalProcess endocardial cell development The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. go.json http://purl.obolibrary.org/obo/GO_0060958 GO:0060959 biolink:BiologicalProcess cardiac neuron development The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. go.json heart neuron development http://purl.obolibrary.org/obo/GO_0060959 GO:0045325 biolink:BiologicalProcess peptidyl-tryptophan hydroxylation The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan. RESID:AA0322 go.json http://purl.obolibrary.org/obo/GO_0045325 gocheck_do_not_annotate GO:0045326 biolink:BiologicalProcess protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine. RESID:AA0323 go.json DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0045326 gocheck_do_not_annotate GO:0045323 biolink:CellularComponent interleukin-1 receptor complex A protein complex that binds interleukin-1; comprises an alpha and a beta subunit. go.json IL-1 receptor complex http://purl.obolibrary.org/obo/GO_0045323 GO:0045324 biolink:BiologicalProcess late endosome to vacuole transport The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. go.json http://purl.obolibrary.org/obo/GO_0045324 GO:0045321 biolink:BiologicalProcess leukocyte activation A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. Wikipedia:Immunologic_activation go.json immune cell activation|leucocyte activation http://purl.obolibrary.org/obo/GO_0045321 GO:0045322 biolink:MolecularActivity unmethylated CpG binding Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. go.json http://purl.obolibrary.org/obo/GO_0045322 GO:0045320 biolink:CellularComponent chloroplast proton-transporting ATP synthase complex A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation. go.json chloroplast hydrogen-translocating F-type ATPase complex|chloroplast proton-transporting F-type ATPase complex|hydrogen-translocating F-type ATPase complex http://purl.obolibrary.org/obo/GO_0045320 GO:0060940 biolink:BiologicalProcess epithelial to mesenchymal transition involved in cardiac fibroblast development A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast. go.json http://purl.obolibrary.org/obo/GO_0060940 GO:0045329 biolink:BiologicalProcess carnitine biosynthetic process The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. go.json carnitine anabolism|carnitine biosynthesis|carnitine formation|carnitine synthesis|vitamin Bt biosynthesis|vitamin Bt biosynthetic process http://purl.obolibrary.org/obo/GO_0045329 GO:0060941 biolink:BiologicalProcess epicardium-derived cardiac fibroblast cell fate commitment The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060941 GO:0060942 biolink:BiologicalProcess neural crest-derived cardiac fibroblast cell differentiation The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060942 GO:0045327 biolink:BiologicalProcess protein-DNA covalent cross-linking via peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue. go.json DNA-protein covalent cross-linking via peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0045327 gocheck_do_not_annotate GO:0045328 biolink:BiologicalProcess cytochrome P450 4A1-heme linkage The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester. RESID:AA0324 go.json cytochrome P450 4A1-haem linkage http://purl.obolibrary.org/obo/GO_0045328 gocheck_do_not_annotate GO:0060943 biolink:BiologicalProcess neural crest-derived cardiac fibroblast cell development The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060943 GO:0060944 biolink:BiologicalProcess neural crest-derived cardiac fibroblast cell fate commitment The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. go.json http://purl.obolibrary.org/obo/GO_0060944 GO:0060945 biolink:BiologicalProcess cardiac neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. go.json heart neuron differentiation http://purl.obolibrary.org/obo/GO_0060945 GO:0060946 biolink:BiologicalProcess cardiac blood vessel endothelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. go.json http://purl.obolibrary.org/obo/GO_0060946 GO:0060947 biolink:BiologicalProcess cardiac vascular smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. go.json heart vascular smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_0060947 GO:0060948 biolink:BiologicalProcess cardiac vascular smooth muscle cell development The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state. go.json heart vascular smooth muscle cell development http://purl.obolibrary.org/obo/GO_0060948 GO:0060949 biolink:BiologicalProcess cardiac vascular smooth muscle cell fate commitment The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell. go.json heart vascular smooth muscle cell fate commitment http://purl.obolibrary.org/obo/GO_0060949 GO:0045336 biolink:CellularComponent clathrin-coated phagocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. go.json clathrin-coated phagosome http://purl.obolibrary.org/obo/GO_0045336 GO:0045337 biolink:BiologicalProcess farnesyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. MetaCyc:PWY-5123 go.json farnesyl diphosphate anabolism|farnesyl diphosphate biosynthesis|farnesyl diphosphate formation|farnesyl diphosphate synthesis http://purl.obolibrary.org/obo/GO_0045337 GO:0045334 biolink:CellularComponent clathrin-coated endocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. NIF_Subcellular:sao1243595998 go.json http://purl.obolibrary.org/obo/GO_0045334 GO:0045335 biolink:CellularComponent phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. Wikipedia:Phagosome go.json phagosome http://purl.obolibrary.org/obo/GO_0045335 GO:0045332 biolink:BiologicalProcess phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. go.json flippase|phospholipid scrambling http://purl.obolibrary.org/obo/GO_0045332 GO:0045333 biolink:BiologicalProcess cellular respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). Wikipedia:Cellular_respiration go.json oxidative metabolic process|oxidative metabolism|respiration http://purl.obolibrary.org/obo/GO_0045333 goslim_candida|goslim_pir|goslim_yeast GO:0045330 biolink:MolecularActivity aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. go.json http://purl.obolibrary.org/obo/GO_0045330 GO:0045331 biolink:MolecularActivity obsolete coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate. go.json coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity|coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity|heterodisulfide reductase activity True http://purl.obolibrary.org/obo/GO_0045331 GO:0060970 biolink:BiologicalProcess embryonic heart tube dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis. go.json http://purl.obolibrary.org/obo/GO_0060970 GO:0060971 biolink:BiologicalProcess embryonic heart tube left/right pattern formation The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place. go.json http://purl.obolibrary.org/obo/GO_0060971 GO:0060972 biolink:BiologicalProcess left/right pattern formation The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. go.json http://purl.obolibrary.org/obo/GO_0060972 GO:0060973 biolink:BiologicalProcess cell migration involved in heart development The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. go.json http://purl.obolibrary.org/obo/GO_0060973 GO:0060974 biolink:BiologicalProcess cell migration involved in heart formation The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. go.json http://purl.obolibrary.org/obo/GO_0060974 GO:0060975 biolink:BiologicalProcess cardioblast migration to the midline involved in heart field formation The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json cardiac progenitor cell midline migration|cardioblast midline convergence http://purl.obolibrary.org/obo/GO_0060975 GO:0045338 biolink:BiologicalProcess farnesyl diphosphate metabolic process The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation. go.json farnesyl diphosphate metabolism http://purl.obolibrary.org/obo/GO_0045338 GO:0060976 biolink:BiologicalProcess coronary vasculature development The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. go.json cardiac blood vessel development|cardiac vasculature development|coronary blood vessel development|heart blood vessel development|heart vasculature development http://purl.obolibrary.org/obo/GO_0060976 GO:0045339 biolink:BiologicalProcess farnesyl diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate. go.json farnesyl diphosphate breakdown|farnesyl diphosphate catabolism|farnesyl diphosphate degradation http://purl.obolibrary.org/obo/GO_0045339 GO:0060977 biolink:BiologicalProcess coronary vasculature morphogenesis The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. go.json cardiac blood vessel morphogenesis|cardiac vasculature morphogenesis|coronary blood vessel morphogenesis|heart blood vessel morphogenesis|heart vasculature morphogenesis http://purl.obolibrary.org/obo/GO_0060977 GO:0060978 biolink:BiologicalProcess angiogenesis involved in coronary vascular morphogenesis Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. go.json angiogenesis involved in cardiac vascular morphogenesis|angiogenesis involved in heart vascular morphogenesis|coronary blood vessel angiogenesis|coronary vasculature angiogenesis http://purl.obolibrary.org/obo/GO_0060978 GO:0060979 biolink:BiologicalProcess vasculogenesis involved in coronary vascular morphogenesis The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. go.json coronary vasculogenesis|vasculogenesis involved in coronary blood vessel morphogenesis http://purl.obolibrary.org/obo/GO_0060979 GO:0045340 biolink:MolecularActivity mercury ion binding Binding to a mercury ion (Hg). go.json Hg ion binding|mercury binding http://purl.obolibrary.org/obo/GO_0045340 GO:0045347 biolink:BiologicalProcess negative regulation of MHC class II biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. go.json down regulation of MHC class II biosynthetic process|down-regulation of MHC class II biosynthetic process|downregulation of MHC class II biosynthetic process|inhibition of MHC class II biosynthetic process|negative regulation of MHC class II anabolism|negative regulation of MHC class II biosynthesis|negative regulation of MHC class II formation|negative regulation of MHC class II synthesis|negative regulation of major histocompatibility complex class II biosynthesis|negative regulation of major histocompatibility complex class II biosynthetic process http://purl.obolibrary.org/obo/GO_0045347 GO:0045348 biolink:BiologicalProcess positive regulation of MHC class II biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. go.json activation of MHC class II biosynthetic process|positive regulation of MHC class II anabolism|positive regulation of MHC class II biosynthesis|positive regulation of MHC class II formation|positive regulation of MHC class II synthesis|positive regulation of major histocompatibility complex class II biosynthesis|positive regulation of major histocompatibility complex class II biosynthetic process|stimulation of MHC class II biosynthetic process|up regulation of MHC class II biosynthetic process|up-regulation of MHC class II biosynthetic process|upregulation of MHC class II biosynthetic process http://purl.obolibrary.org/obo/GO_0045348 GO:0045345 biolink:BiologicalProcess positive regulation of MHC class I biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. go.json activation of MHC class I biosynthetic process|positive regulation of MHC class I anabolism|positive regulation of MHC class I biosynthesis|positive regulation of MHC class I formation|positive regulation of MHC class I synthesis|positive regulation of major histocompatibility complex class I biosynthesis|positive regulation of major histocompatibility complex class I biosynthetic process|stimulation of MHC class I biosynthetic process|up regulation of MHC class I biosynthetic process|up-regulation of MHC class I biosynthetic process|upregulation of MHC class I biosynthetic process http://purl.obolibrary.org/obo/GO_0045345 GO:0045346 biolink:BiologicalProcess regulation of MHC class II biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. go.json regulation of MHC class II anabolism|regulation of MHC class II biosynthesis|regulation of MHC class II formation|regulation of MHC class II synthesis|regulation of major histocompatibility complex class II biosynthesis|regulation of major histocompatibility complex class II biosynthetic process http://purl.obolibrary.org/obo/GO_0045346 GO:0045343 biolink:BiologicalProcess regulation of MHC class I biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. go.json regulation of MHC class I anabolism|regulation of MHC class I biosynthesis|regulation of MHC class I formation|regulation of MHC class I synthesis|regulation of major histocompatibility complex class I biosynthesis|regulation of major histocompatibility complex class I biosynthetic process http://purl.obolibrary.org/obo/GO_0045343 GO:0045344 biolink:BiologicalProcess negative regulation of MHC class I biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. go.json down regulation of MHC class I biosynthetic process|down-regulation of MHC class I biosynthetic process|downregulation of MHC class I biosynthetic process|inhibition of MHC class I biosynthetic process|negative regulation of MHC class I anabolism|negative regulation of MHC class I biosynthesis|negative regulation of MHC class I formation|negative regulation of MHC class I synthesis|negative regulation of major histocompatibility complex class I biosynthesis|negative regulation of major histocompatibility complex class I biosynthetic process http://purl.obolibrary.org/obo/GO_0045344 GO:0045341 biolink:BiologicalProcess MHC class I biosynthetic process The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I. go.json MHC class I anabolism|MHC class I biosynthesis|MHC class I formation|MHC class I synthesis|major histocompatibility complex class I biosynthesis|major histocompatibility complex class I biosynthetic process http://purl.obolibrary.org/obo/GO_0045341 GO:0045342 biolink:BiologicalProcess MHC class II biosynthetic process The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II. go.json MHC class II anabolism|MHC class II biosynthesis|MHC class II formation|MHC class II synthesis|major histocompatibility complex class II biosynthesis|major histocompatibility complex class II biosynthetic process http://purl.obolibrary.org/obo/GO_0045342 GO:0060960 biolink:BiologicalProcess cardiac neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart. go.json heart neuron fate commitment http://purl.obolibrary.org/obo/GO_0060960 GO:0060961 biolink:MolecularActivity phospholipase D inhibitor activity Binds to and stops, prevents or reduces the activity of phospholipase D. go.json http://purl.obolibrary.org/obo/GO_0060961 GO:0060962 biolink:BiologicalProcess regulation of ribosomal protein gene transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. go.json regulation of ribosomal protein gene transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0060962 GO:0060963 biolink:BiologicalProcess positive regulation of ribosomal protein gene transcription by RNA polymerase II Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. go.json positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0060963 GO:0045349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045349 GO:0060964 biolink:BiologicalProcess regulation of miRNA-mediated gene silencing A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs). go.json regulation of gene silencing by miRNA|regulation of gene silencing by microRNA http://purl.obolibrary.org/obo/GO_0060964 GO:0060965 biolink:BiologicalProcess negative regulation of miRNA-mediated gene silencing A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA). go.json negative regulation of gene silencing by miRNA|negative regulation of gene silencing by microRNA http://purl.obolibrary.org/obo/GO_0060965 GO:0060966 biolink:BiologicalProcess regulation of gene silencing by regulatory ncRNA Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. go.json regulation of gene silencing by RNA http://purl.obolibrary.org/obo/GO_0060966 GO:0060967 biolink:BiologicalProcess negative regulation of gene silencing by regulatory ncRNA Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. go.json negative regulation of gene silencing by RNA|negative regulation of gene silencing by ncRNA http://purl.obolibrary.org/obo/GO_0060967 GO:0060968 biolink:BiologicalProcess obsolete regulation of gene silencing OBSOLETE. Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. go.json True http://purl.obolibrary.org/obo/GO_0060968 GO:0060969 biolink:BiologicalProcess obsolete negative regulation of gene silencing OBSOLETE. Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. go.json True http://purl.obolibrary.org/obo/GO_0060969 GO:0035999 biolink:BiologicalProcess tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. MetaCyc:PWY-2201 go.json http://purl.obolibrary.org/obo/GO_0035999 GO:0035991 biolink:MolecularActivity nitric oxide sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO). go.json NO sensor activity http://purl.obolibrary.org/obo/GO_0035991 GO:0035992 biolink:BiologicalProcess tendon formation The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0035992 GO:0035993 biolink:BiologicalProcess deltoid tuberosity development The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase. go.json http://purl.obolibrary.org/obo/GO_0035993 GO:0035994 biolink:BiologicalProcess response to muscle stretch Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. go.json http://purl.obolibrary.org/obo/GO_0035994 GO:0035995 biolink:BiologicalProcess detection of muscle stretch The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0035995 GO:0035996 biolink:CellularComponent rhabdomere microvillus Thin cylindrical membrane-covered projection on the surface of a rhabdomere. go.json http://purl.obolibrary.org/obo/GO_0035996 GO:0035997 biolink:CellularComponent rhabdomere microvillus membrane The portion of the plasma membrane surrounding a microvillus of a rhabdomere. go.json http://purl.obolibrary.org/obo/GO_0035997 GO:0035998 biolink:BiologicalProcess 7,8-dihydroneopterin 3'-triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate. go.json 7,8-dihydroneopterin 3'-triphosphate anabolism|7,8-dihydroneopterin 3'-triphosphate biosynthesis|7,8-dihydroneopterin 3'-triphosphate formation|7,8-dihydroneopterin 3'-triphosphate synthesis http://purl.obolibrary.org/obo/GO_0035998 GO:0035990 biolink:BiologicalProcess tendon cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance. go.json muscle attachment cell differentiation|tenocyte differentiation http://purl.obolibrary.org/obo/GO_0035990 GO:0035988 biolink:BiologicalProcess chondrocyte proliferation The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. go.json cartilage cell proliferation|chondrocyte cell proliferation http://purl.obolibrary.org/obo/GO_0035988 GO:0035989 biolink:BiologicalProcess tendon development The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. go.json sinew development http://purl.obolibrary.org/obo/GO_0035989 GO:0035980 biolink:BiologicalProcess obsolete invasive growth in response to nitrogen limitation OBSOLETE. The growth of colonies in filamentous chains of cells as a result of a reduced availability of nitrogen. go.json invasive growth in response to nitrogen limitation True http://purl.obolibrary.org/obo/GO_0035980 GO:0035981 biolink:BiologicalProcess tongue muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell. go.json http://purl.obolibrary.org/obo/GO_0035981 GO:0035982 biolink:BiologicalProcess obsolete age-dependent behavioral decline OBSOLETE. A developmental process that arises as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory. go.json age-dependent behavioural decline|age-related behavioral decline|behavioral aging True http://purl.obolibrary.org/obo/GO_0035982 GO:0035983 biolink:BiologicalProcess response to trichostatin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. go.json http://purl.obolibrary.org/obo/GO_0035983 GO:0035984 biolink:BiologicalProcess cellular response to trichostatin A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. go.json http://purl.obolibrary.org/obo/GO_0035984 GO:0035985 biolink:CellularComponent senescence-associated heterochromatin focus A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. go.json SAHF|senescence-associated heterochromatin foci http://purl.obolibrary.org/obo/GO_0035985 GO:0035986 biolink:BiologicalProcess obsolete senescence-associated heterochromatin focus assembly OBSOLETE. The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes. go.json SAHF formation|senescence-associated heterochromatin foci formation|senescence-associated heterochromatin focus formation True http://purl.obolibrary.org/obo/GO_0035986 GO:0035987 biolink:BiologicalProcess endodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. go.json endoderm cell differentiation http://purl.obolibrary.org/obo/GO_0035987 GO:0035977 biolink:BiologicalProcess protein deglycosylation involved in glycoprotein catabolic process The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein. go.json http://purl.obolibrary.org/obo/GO_0035977 gocheck_do_not_annotate GO:0035978 biolink:BiologicalProcess obsolete histone H2A-S139 phosphorylation OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone. go.json histone H2A.x phosphorylation at S139 True http://purl.obolibrary.org/obo/GO_0035978 GO:0035979 biolink:MolecularActivity histone H2AXS139 kinase activity Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX. go.json histone H2AS139 kinase activity|histone kinase activity (H2A-S139 specific)|histone kinase activity (H2A.x-S139 specific) http://purl.obolibrary.org/obo/GO_0035979 GO:0035970 biolink:BiologicalProcess peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. go.json http://purl.obolibrary.org/obo/GO_0035970 gocheck_do_not_annotate GO:0035971 biolink:BiologicalProcess peptidyl-histidine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine. go.json http://purl.obolibrary.org/obo/GO_0035971 gocheck_do_not_annotate GO:0035972 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035972 GO:0035973 biolink:BiologicalProcess aggrephagy The selective degradation of protein aggregates by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0035973 GO:0035974 biolink:CellularComponent meiotic spindle pole body The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome. go.json http://purl.obolibrary.org/obo/GO_0035974 GO:0035975 biolink:BiologicalProcess carbamoyl phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. go.json carbamoyl phosphate breakdown|carbamoyl phosphate catabolism|carbamoyl phosphate degradation http://purl.obolibrary.org/obo/GO_0035975 GO:0035976 biolink:CellularComponent transcription factor AP-1 complex A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. go.json AP-1 complex|AP1 complex|Activating protein 1 complex|transcription factor AP1 complex http://purl.obolibrary.org/obo/GO_0035976 GO:0035966 biolink:BiologicalProcess response to topologically incorrect protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. go.json response to misfolded or unfolded protein http://purl.obolibrary.org/obo/GO_0035966 GO:0035967 biolink:BiologicalProcess cellular response to topologically incorrect protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. go.json cellular response to misfolded or unfolded protein http://purl.obolibrary.org/obo/GO_0035967 GO:0035968 biolink:BiologicalProcess obsolete regulation of sterol import by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of sterol import, by regulation of transcription from an RNA polymerase II promoter. go.json regulation of sterol import by regulation of transcription from Pol II promoter|regulation of sterol influx by regulation of transcription from Pol II promoter|regulation of sterol influx by regulation of transcription from RNA polymerase II promoter|regulation of sterol uptake by regulation of transcription from Pol II promoter|regulation of sterol uptake by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035968 GO:0035969 biolink:BiologicalProcess obsolete positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of sterol import by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of sterol import by activation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from Pol II promoter|positive regulation of sterol import by stimulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by up regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by upregulation of transcription from RNA polymerase II promoter|positive regulation of sterol influx by activation of transcription from RNA polymerase II promoter|positive regulation of sterol influx by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter|positive regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter|positive regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter|positive regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter|positive regulation of sterol uptake by activation of transcription from RNA polymerase II promoter|positive regulation of sterol uptake by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter|positive regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter|positive regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter|positive regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035969 GO:0035960 biolink:BiologicalProcess obsolete regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of ergosterol biosynthetic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of ergosterol anabolism by regulation of transcription from Pol II promoter|regulation of ergosterol anabolism by regulation of transcription from RNA polymerase II promoter|regulation of ergosterol biosynthesis by regulation of transcription from Pol II promoter|regulation of ergosterol biosynthesis by regulation of transcription from RNA polymerase II promoter|regulation of ergosterol biosynthetic process by regulation of transcription from Pol II promoter|regulation of ergosterol formation by regulation of transcription from Pol II promoter|regulation of ergosterol formation by regulation of transcription from RNA polymerase II promoter|regulation of ergosterol synthesis by regulation of transcription from Pol II promoter|regulation of ergosterol synthesis by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035960 GO:0035961 biolink:BiologicalProcess obsolete positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of ergosterol biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of ergosterol anabolism by positive regulation of transcription from Pol II promoter|positive regulation of ergosterol anabolism by positive regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol anabolism by up regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol anabolism by up-regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol anabolism by upregulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthesis by positive regulation of transcription from Pol II promoter|positive regulation of ergosterol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthesis by up regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthesis by up-regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthesis by upregulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthetic process by activation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from Pol II promoter|positive regulation of ergosterol biosynthetic process by stimulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthetic process by up regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthetic process by up-regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol biosynthetic process by upregulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol formation by positive regulation of transcription from Pol II promoter|positive regulation of ergosterol formation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol formation by up regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol formation by up-regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol formation by upregulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol synthesis by positive regulation of transcription from Pol II promoter|positive regulation of ergosterol synthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol synthesis by up regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol synthesis by up-regulation of transcription from RNA polymerase II promoter|positive regulation of ergosterol synthesis by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035961 GO:0035962 biolink:BiologicalProcess response to interleukin-13 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. go.json response to IL-13 http://purl.obolibrary.org/obo/GO_0035962 GO:0035963 biolink:BiologicalProcess cellular response to interleukin-13 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. go.json cellular response to IL-13 http://purl.obolibrary.org/obo/GO_0035963 GO:0035964 biolink:BiologicalProcess COPI-coated vesicle budding The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle. go.json COPI vesicle budding http://purl.obolibrary.org/obo/GO_0035964 GO:0035965 biolink:BiologicalProcess cardiolipin acyl-chain remodeling Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. go.json cardiolipin acyl-chain remodelling|cardiolipin maturation|diphosphatidylglycerol remodeling http://purl.obolibrary.org/obo/GO_0035965 GO:0035955 biolink:BiologicalProcess obsolete negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of dipeptide transport by down regulation of transcription from RNA polymerase II promoter|negative regulation of dipeptide transport by down-regulation of transcription from RNA polymerase II promoter|negative regulation of dipeptide transport by downregulation of transcription from RNA polymerase II promoter|negative regulation of dipeptide transport by inhibition of transcription from RNA polymerase II promoter|negative regulation of dipeptide transport by negative regulation of transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_0035955 GO:0035956 biolink:BiologicalProcess obsolete regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of the breakdown of starch, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of starch breakdown by regulation of transcription from Pol II promoter|regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter|regulation of starch catabolic process by regulation of transcription from Pol II promoter|regulation of starch catabolism by regulation of transcription from Pol II promoter|regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter|regulation of starch degradation by regulation of transcription from Pol II promoter|regulation of starch degradation by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035956 GO:0035957 biolink:BiologicalProcess obsolete positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of the breakdown of starch, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of starch breakdown by regulation of transcription from Pol II promoter|positive regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter|positive regulation of starch catabolic process by regulation of transcription from Pol II promoter|positive regulation of starch catabolism by regulation of transcription from Pol II promoter|positive regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter|positive regulation of starch degradation by regulation of transcription from Pol II promoter|positive regulation of starch degradation by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035957 GO:0035958 biolink:BiologicalProcess obsolete regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of the glyoxylate cycle by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of glyoxylate bypass by regulation of transcription from Pol II promoter|regulation of glyoxylate bypass by regulation of transcription from RNA polymerase II promoter|regulation of glyoxylate cycle by regulation of transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_0035958 GO:0035959 biolink:BiologicalProcess obsolete positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of the glyoxylate cycle by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of glyoxylate bypass by positive regulation of transcription from Pol II promoter|positive regulation of glyoxylate bypass by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate bypass by up regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate bypass by up-regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate bypass by upregulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by activation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from Pol II promoter|positive regulation of glyoxylate cycle by stimulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by up regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by up-regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035959 GO:0035950 biolink:BiologicalProcess obsolete regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of oligopeptide transport, by regulation of transcription from an RNA polymerase II promoter. go.json regulation of oligopeptide transport by regulation of transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_0035950 GO:0035951 biolink:BiologicalProcess obsolete positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of oligopeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of oligopeptide transport by activation of transcription from RNA polymerase II promoter|positive regulation of oligopeptide transport by positive regulation of transcription from Pol II promoter|positive regulation of oligopeptide transport by stimulation of transcription from RNA polymerase II promoter|positive regulation of oligopeptide transport by up regulation of transcription from RNA polymerase II promoter|positive regulation of oligopeptide transport by up-regulation of transcription from RNA polymerase II promoter|positive regulation of oligopeptide transport by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035951 GO:0035952 biolink:BiologicalProcess obsolete negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of oligopeptide transport by down regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by down-regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by downregulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by inhibition of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_0035952 GO:0035953 biolink:BiologicalProcess obsolete regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of dipeptide transport, by regulation of transcription from an RNA polymerase II promoter. go.json regulation of dipeptide transport by regulation of transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_0035953 GO:0035954 biolink:BiologicalProcess obsolete positive regulation of dipeptide transport by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of dipeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of dipeptide transport by activation of transcription from RNA polymerase II promoter|positive regulation of dipeptide transport by positive regulation of transcription from Pol II promoter|positive regulation of dipeptide transport by stimulation of transcription from RNA polymerase II promoter|positive regulation of dipeptide transport by up regulation of transcription from RNA polymerase II promoter|positive regulation of dipeptide transport by up-regulation of transcription from RNA polymerase II promoter|positive regulation of dipeptide transport by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0035954 GO:0070273 biolink:MolecularActivity phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. go.json http://purl.obolibrary.org/obo/GO_0070273 GO:0070274 biolink:CellularComponent RES complex A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p. go.json pre-mRNA retention and splicing complex http://purl.obolibrary.org/obo/GO_0070274 GO:0070271 biolink:BiologicalProcess obsolete protein complex biogenesis OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. go.json protein complex biogenesis and assembly True http://purl.obolibrary.org/obo/GO_0070271 GO:0070272 biolink:BiologicalProcess obsolete proton-transporting ATP synthase complex biogenesis OBSOLETE. The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. go.json F-type ATPase complex biogenesis True http://purl.obolibrary.org/obo/GO_0070272 GO:0070270 biolink:BiologicalProcess obsolete mitotic catastrophe OBSOLETE. A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation. go.json cell death occurring during metaphase|cell death preceded by multinucleation|mitotic catastrophe True http://purl.obolibrary.org/obo/GO_0070270 GO:0070279 biolink:MolecularActivity vitamin B6 binding Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0070279 GO:0070277 biolink:BiologicalProcess iodide oxidation The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons. go.json http://purl.obolibrary.org/obo/GO_0070277 GO:0070278 biolink:BiologicalProcess extracellular matrix constituent secretion The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell. go.json ECM constituent secretion|ECM secretion http://purl.obolibrary.org/obo/GO_0070278 GO:0070275 biolink:BiologicalProcess aerobic ammonia oxidation to nitrite via pyruvic oxime The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite. MetaCyc:PWY-2242 go.json http://purl.obolibrary.org/obo/GO_0070275 GO:0070276 biolink:BiologicalProcess halogen metabolic process The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds. go.json halogen metabolism http://purl.obolibrary.org/obo/GO_0070276 GO:0070262 biolink:BiologicalProcess peptidyl-serine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. go.json http://purl.obolibrary.org/obo/GO_0070262 gocheck_do_not_annotate GO:0070263 biolink:CellularComponent external side of fungal-type cell wall The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents. go.json http://purl.obolibrary.org/obo/GO_0070263 GO:0070260 biolink:MolecularActivity 5'-tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. go.json http://purl.obolibrary.org/obo/GO_0070260 GO:0070261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070261 GO:0070268 biolink:BiologicalProcess cornification A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). go.json http://purl.obolibrary.org/obo/GO_0070268 GO:0070269 biolink:BiologicalProcess pyroptosis A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. go.json http://purl.obolibrary.org/obo/GO_0070269 GO:0070266 biolink:BiologicalProcess necroptotic process A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. go.json PARP-dependent cell death|RIPK1-mediated regulated necrosis|TNF-induced necroptosis|activation of necroptosis|activation of necroptosis by extracellular signals|activation of necroptosis in response to extracellular signals|activation of necroptosis of activated-T cells|establishment of necroptosis|establishment of necroptosis of activated-T cells|extracellular signal-induced necroptosis|induction of necroptosis|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necroptosis|parthanatos|programmed necrosis|programmed necrotic cell death http://purl.obolibrary.org/obo/GO_0070266 GO:0070267 biolink:BiologicalProcess obsolete oncosis OBSOLETE. A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death. go.json True http://purl.obolibrary.org/obo/GO_0070267 GO:0070264 biolink:CellularComponent transcription factor TFIIIE complex A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins. go.json http://purl.obolibrary.org/obo/GO_0070264 GO:0070265 biolink:BiologicalProcess obsolete necrotic cell death OBSOLETE. A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. go.json cellular necrosis|necrosis True http://purl.obolibrary.org/obo/GO_0070265 GO:0070295 biolink:BiologicalProcess renal water absorption A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. go.json nephron water absorption|renal water reabsorption http://purl.obolibrary.org/obo/GO_0070295 GO:0070296 biolink:BiologicalProcess sarcoplasmic reticulum calcium ion transport The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0070296 GO:0070293 biolink:BiologicalProcess renal absorption A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). go.json nephron absorption|renal reabsorption http://purl.obolibrary.org/obo/GO_0070293 GO:0070294 biolink:BiologicalProcess renal sodium ion absorption A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. go.json nephron sodium ion absorption|renal sodium ion reabsorption http://purl.obolibrary.org/obo/GO_0070294 GO:0070291 biolink:BiologicalProcess N-acylethanolamine metabolic process The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group. go.json N-acylethanolamine metabolism|NAE metabolic process|NAE metabolism http://purl.obolibrary.org/obo/GO_0070291 GO:0070292 biolink:BiologicalProcess N-acylphosphatidylethanolamine metabolic process The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. go.json N-acylphosphatidylethanolamine metabolism|NAPE metabolic process|NAPE metabolism http://purl.obolibrary.org/obo/GO_0070292 GO:0070290 biolink:MolecularActivity N-acylphosphatidylethanolamine-specific phospholipase D activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). EC:3.1.4.4|Reactome:R-HSA-2466831 go.json N-acyl-phosphatidylethanolamine-specific phospholipase D activity|NAPE-specific phospholipase D activity http://purl.obolibrary.org/obo/GO_0070290 goslim_chembl GO:0070299 biolink:BiologicalProcess positive regulation of phosphorelay signal transduction system Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system. go.json activation of two-component signal transduction|positive regulation of histidyl-aspartyl phosphorelay|positive regulation of two-component signal transduction system (phosphorelay)|stimulation of two-component signal transduction|up regulation of two-component signal transduction|up-regulation of two-component signal transduction|upregulation of two-component signal transduction http://purl.obolibrary.org/obo/GO_0070299 GO:0070297 biolink:BiologicalProcess regulation of phosphorelay signal transduction system Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system. go.json regulation of histidyl-aspartyl phosphorelay|regulation of two-component signal transduction system|regulation of two-component signal transduction system (phosphorelay) http://purl.obolibrary.org/obo/GO_0070297 GO:0070298 biolink:BiologicalProcess negative regulation of phosphorelay signal transduction system Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system. go.json down regulation of two-component signal transduction|down-regulation of two-component signal transduction|downregulation of two-component signal transduction|inhibition of two-component signal transduction|negative regulation of histidyl-aspartyl phosphorelay|negative regulation of two-component signal transduction system (phosphorelay) http://purl.obolibrary.org/obo/GO_0070298 GO:0070284 biolink:MolecularActivity 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine. go.json HMP-P synthase activity|ThiC http://purl.obolibrary.org/obo/GO_0070284 GO:0070285 biolink:BiologicalProcess pigment cell development The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. go.json http://purl.obolibrary.org/obo/GO_0070285 GO:0070282 biolink:MolecularActivity pyridoxine binding Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0070282 GO:0070283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070283 GO:0070280 biolink:MolecularActivity pyridoxal binding Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0070280 GO:0070281 biolink:MolecularActivity pyridoxamine binding Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0070281 GO:0070288 biolink:CellularComponent ferritin complex A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain. go.json http://purl.obolibrary.org/obo/GO_0070288 GO:0070289 biolink:CellularComponent extracellular ferritin complex A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains. go.json serum ferritin complex http://purl.obolibrary.org/obo/GO_0070289 GO:0070286 biolink:BiologicalProcess axonemal dynein complex assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. go.json dynein arm assembly http://purl.obolibrary.org/obo/GO_0070286 GO:0070287 biolink:MolecularActivity ferritin receptor activity Combining with ferritin, and delivering ferritin into the cell via endocytosis. go.json ferritin complex receptor activity http://purl.obolibrary.org/obo/GO_0070287 GO:0045230 biolink:BiologicalProcess capsule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi. go.json capsule organisation|capsule organization and biogenesis http://purl.obolibrary.org/obo/GO_0045230 goslim_pir GO:1901969 biolink:BiologicalProcess positive regulation of polynucleotide 3'-phosphatase activity Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity. go.json activation of 2'(3')-polynucleotidase activity|activation of 5'-polynucleotidekinase 3'-phosphatase activity|activation of DNA 3'-phosphatase activity|activation of deoxyribonucleate 3'-phosphatase activity|activation of polynucleotide 3'-phosphatase activity|activation of polynucleotide 3'-phosphohydrolase activity|positive regulation of 2'(3')-polynucleotidase activity|positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity|positive regulation of DNA 3'-phosphatase activity|positive regulation of deoxyribonucleate 3'-phosphatase activity|positive regulation of polynucleotide 3'-phosphohydrolase activity|up regulation of 2'(3')-polynucleotidase activity|up regulation of 5'-polynucleotidekinase 3'-phosphatase activity|up regulation of DNA 3'-phosphatase activity|up regulation of deoxyribonucleate 3'-phosphatase activity|up regulation of polynucleotide 3'-phosphatase activity|up regulation of polynucleotide 3'-phosphohydrolase activity|up-regulation of 2'(3')-polynucleotidase activity|up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity|up-regulation of DNA 3'-phosphatase activity|up-regulation of deoxyribonucleate 3'-phosphatase activity|up-regulation of polynucleotide 3'-phosphatase activity|up-regulation of polynucleotide 3'-phosphohydrolase activity|upregulation of 2'(3')-polynucleotidase activity|upregulation of 5'-polynucleotidekinase 3'-phosphatase activity|upregulation of DNA 3'-phosphatase activity|upregulation of deoxyribonucleate 3'-phosphatase activity|upregulation of polynucleotide 3'-phosphatase activity|upregulation of polynucleotide 3'-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_1901969 gocheck_do_not_annotate GO:1901967 biolink:BiologicalProcess negative regulation of cellular response to iron ion starvation Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation. go.json down regulation of cellular response to iron ion starvation|down-regulation of cellular response to iron ion starvation|downregulation of cellular response to iron ion starvation|inhibition of cellular response to iron ion starvation http://purl.obolibrary.org/obo/GO_1901967 GO:1901968 biolink:BiologicalProcess regulation of polynucleotide 3'-phosphatase activity Any process that modulates the frequency, rate or extent of polynucleotide 3'-phosphatase activity. go.json regulation of 2'(3')-polynucleotidase activity|regulation of 5'-polynucleotidekinase 3'-phosphatase activity|regulation of DNA 3'-phosphatase activity|regulation of deoxyribonucleate 3'-phosphatase activity|regulation of polynucleotide 3'-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_1901968 gocheck_do_not_annotate GO:1901965 biolink:BiologicalProcess endoplasmic reticulum to chloroplast transport The directed movement of substances from endoplasmic reticulum to chloroplast. go.json ER to chloroplast transport http://purl.obolibrary.org/obo/GO_1901965 GO:1901966 biolink:BiologicalProcess regulation of cellular response to iron ion starvation Any process that modulates the frequency, rate or extent of cellular response to iron ion starvation. go.json http://purl.obolibrary.org/obo/GO_1901966 GO:1901963 biolink:BiologicalProcess regulation of cell proliferation involved in outflow tract morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1901963 GO:0045237 biolink:MolecularActivity CXCR1 chemokine receptor binding Binding to a CXCR1 chemokine receptor. go.json CXCR1 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0045237 GO:1901964 biolink:BiologicalProcess positive regulation of cell proliferation involved in outflow tract morphogenesis Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. go.json activation of cell proliferation involved in outflow tract morphogenesis|up regulation of cell proliferation involved in outflow tract morphogenesis|up-regulation of cell proliferation involved in outflow tract morphogenesis|upregulation of cell proliferation involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_1901964 GO:0045238 biolink:MolecularActivity CXCR2 chemokine receptor binding Binding to a CXCR2 chemokine receptor. go.json CXCR2 chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0045238 GO:1901961 biolink:BiologicalProcess isobutanol biosynthetic process The chemical reactions and pathways resulting in the formation of isobutanol. go.json isobutanol anabolism|isobutanol biosynthesis|isobutanol formation|isobutanol synthesis http://purl.obolibrary.org/obo/GO_1901961 GO:0045235 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045235 GO:0045236 biolink:MolecularActivity CXCR chemokine receptor binding Binding to a chemokine receptor in the CXCR family. go.json C-X-C chemokine receptor ligand|CXC chemokine receptor ligand|alpha chemokine receptor binding|alpha chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0045236 GO:1901962 biolink:BiologicalProcess S-adenosyl-L-methionine transmembrane transport The directed movement of S-adenosyl-L-methionine across a membrane. go.json S-adenosylmethionine transmembrane transport|SAM transmembrane transport http://purl.obolibrary.org/obo/GO_1901962 GO:0045233 biolink:MolecularActivity obsolete natural killer cell receptor activity OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family. go.json Ly49i|NK cell receptor activity|natural killer cell receptor activity True http://purl.obolibrary.org/obo/GO_0045233 GO:0045234 biolink:BiologicalProcess protein palmitoleylation The covalent attachment of a palmitoleyl group to a protein. go.json protein amino acid palmitoleylation http://purl.obolibrary.org/obo/GO_0045234 gocheck_do_not_annotate GO:1901960 biolink:BiologicalProcess isobutanol metabolic process The chemical reactions and pathways involving isobutanol. go.json isobutanol metabolism http://purl.obolibrary.org/obo/GO_1901960 GO:0045231 biolink:BiologicalProcess slime layer organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. go.json slime layer organisation|slime layer organization and biogenesis http://purl.obolibrary.org/obo/GO_0045231 goslim_pir GO:0045232 biolink:BiologicalProcess S-layer organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria. go.json S-layer organisation|S-layer organization and biogenesis http://purl.obolibrary.org/obo/GO_0045232 GO:0060870 biolink:BiologicalProcess cell wall disassembly involved in floral organ abscission A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission. go.json http://purl.obolibrary.org/obo/GO_0060870 GO:0060871 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060871 GO:0060872 biolink:BiologicalProcess semicircular canal development The progression of the semicircular canal from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060872 GO:0060873 biolink:BiologicalProcess anterior semicircular canal development The progession of the anterior semicircular canal from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060873 GO:0060874 biolink:BiologicalProcess posterior semicircular canal development The progession of the posterior semicircular canal from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060874 GO:0060875 biolink:BiologicalProcess lateral semicircular canal development The progession of the lateral semicircular canal from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060875 GO:0060876 biolink:BiologicalProcess semicircular canal formation The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes. go.json http://purl.obolibrary.org/obo/GO_0060876 GO:0045239 biolink:CellularComponent tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. go.json TCA cycle enzyme complex http://purl.obolibrary.org/obo/GO_0045239 goslim_pir GO:0060877 biolink:BiologicalProcess regionalization involved in semicircular canal formation The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals. go.json http://purl.obolibrary.org/obo/GO_0060877 GO:0060878 biolink:BiologicalProcess pouch outgrowth involved in semicircular canal formation The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal. go.json http://purl.obolibrary.org/obo/GO_0060878 GO:0060879 biolink:BiologicalProcess semicircular canal fusion Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms during the process of semicircular canal formation. go.json http://purl.obolibrary.org/obo/GO_0060879 GO:0045240 biolink:CellularComponent dihydrolipoyl dehydrogenase complex A protein complex that possesses alpha-ketoglutarate dehydrogenase activity. go.json 2-oxoglutarate dehydrogenase complex|alpha-ketoglutarate dehydrogenase complex http://purl.obolibrary.org/obo/GO_0045240 GO:0045241 biolink:CellularComponent cytosolic alpha-ketoglutarate dehydrogenase complex Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity. go.json 2-oxoglutarate dehydrogenase complex http://purl.obolibrary.org/obo/GO_0045241 GO:1901978 biolink:BiologicalProcess positive regulation of cell cycle checkpoint Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint. go.json activation of cell cycle checkpoint|positive regulation of G1/S checkpoint|positive regulation of G1/S transition checkpoint|up regulation of cell cycle checkpoint|up-regulation of cell cycle checkpoint|upregulation of cell cycle checkpoint http://purl.obolibrary.org/obo/GO_1901978 GO:1901979 biolink:BiologicalProcess regulation of inward rectifier potassium channel activity Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity. go.json regulation of Kir channel activity http://purl.obolibrary.org/obo/GO_1901979 gocheck_do_not_annotate GO:1901976 biolink:BiologicalProcess regulation of cell cycle checkpoint Any process that modulates the frequency, rate or extent of cell cycle checkpoint. go.json regulation of G1/S checkpoint|regulation of G1/S transition checkpoint http://purl.obolibrary.org/obo/GO_1901976 gocheck_do_not_manually_annotate GO:1901977 biolink:BiologicalProcess negative regulation of cell cycle checkpoint Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint. go.json down regulation of cell cycle checkpoint|down-regulation of cell cycle checkpoint|downregulation of cell cycle checkpoint|inhibition of cell cycle checkpoint|negative regulation of G1/S checkpoint|negative regulation of G1/S transition checkpoint http://purl.obolibrary.org/obo/GO_1901977 gocheck_do_not_manually_annotate GO:0045248 biolink:CellularComponent cytosolic oxoglutarate dehydrogenase complex A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). go.json http://purl.obolibrary.org/obo/GO_0045248 GO:1901974 biolink:MolecularActivity glycerate transmembrane transporter activity Enables the transfer of glycerate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1901974 GO:1901975 biolink:BiologicalProcess glycerate transmembrane transport The process in which glycerate is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1901975 GO:0045249 biolink:CellularComponent cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. go.json http://purl.obolibrary.org/obo/GO_0045249 GO:0045246 biolink:CellularComponent cytosolic tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle. go.json TCA cycle enzyme complex|tricarboxylic acid cycle enzyme complex http://purl.obolibrary.org/obo/GO_0045246 GO:1901972 biolink:BiologicalProcess obsolete positive regulation of DNA-5-methylcytosine glycosylase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity. go.json activation of DNA-5-methylcytosine glycosylase activity|up regulation of DNA-5-methylcytosine glycosylase activity|up-regulation of DNA-5-methylcytosine glycosylase activity|upregulation of DNA-5-methylcytosine glycosylase activity True http://purl.obolibrary.org/obo/GO_1901972 GO:0045247 biolink:CellularComponent cytosolic electron transfer flavoprotein complex A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors. go.json http://purl.obolibrary.org/obo/GO_0045247 GO:1901973 biolink:MolecularActivity proline binding Binding to proline. go.json http://purl.obolibrary.org/obo/GO_1901973 GO:1901970 biolink:BiologicalProcess positive regulation of mitotic sister chromatid separation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. go.json activation of chromosome separation during mitosis|activation of mitotic chromosome separation|activation of mitotic sister chromatid resolution|activation of mitotic sister chromatid separation|activation of sister chromatid separation during mitosis|positive regulation of chromosome separation during mitosis|positive regulation of mitotic chromosome separation|positive regulation of mitotic sister chromatid resolution|positive regulation of sister chromatid separation during mitosis|up regulation of chromosome separation during mitosis|up regulation of mitotic chromosome separation|up regulation of mitotic sister chromatid resolution|up regulation of mitotic sister chromatid separation|up regulation of sister chromatid separation during mitosis|up-regulation of chromosome separation during mitosis|up-regulation of mitotic chromosome separation|up-regulation of mitotic sister chromatid resolution|up-regulation of mitotic sister chromatid separation|up-regulation of sister chromatid separation during mitosis|upregulation of chromosome separation during mitosis|upregulation of mitotic chromosome separation|upregulation of mitotic sister chromatid resolution|upregulation of mitotic sister chromatid separation|upregulation of sister chromatid separation during mitosis http://purl.obolibrary.org/obo/GO_1901970 GO:0045244 biolink:CellularComponent succinate-CoA ligase complex (GDP-forming) A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP. go.json succinyl-CoA synthetase, GDP-forming http://purl.obolibrary.org/obo/GO_0045244 GO:1901971 biolink:BiologicalProcess obsolete regulation of DNA-5-methylcytosine glycosylase activity OBSOLETE. Any process that modulates the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity. go.json True http://purl.obolibrary.org/obo/GO_1901971 GO:0045245 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045245 GO:0045242 biolink:CellularComponent isocitrate dehydrogenase complex (NAD+) Complex that possesses isocitrate dehydrogenase (NAD+) activity. go.json http://purl.obolibrary.org/obo/GO_0045242 GO:0045243 biolink:CellularComponent cytosolic isocitrate dehydrogenase complex (NAD+) Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity. go.json isocitrate dehydrogenase complex (NAD+) http://purl.obolibrary.org/obo/GO_0045243 GO:0060860 biolink:BiologicalProcess regulation of floral organ abscission Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs. go.json http://purl.obolibrary.org/obo/GO_0060860 GO:0060861 biolink:BiologicalProcess positive regulation of floral organ abscission Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs. go.json http://purl.obolibrary.org/obo/GO_0060861 GO:0060862 biolink:BiologicalProcess negative regulation of floral organ abscission Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs. go.json http://purl.obolibrary.org/obo/GO_0060862 GO:0060863 biolink:BiologicalProcess regulation of floral organ abscission by signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission. go.json http://purl.obolibrary.org/obo/GO_0060863 GO:0060864 biolink:BiologicalProcess obsolete positive regulation of floral organ abscission by small GTPase mediated signal transduction OBSOLETE. Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission. go.json True http://purl.obolibrary.org/obo/GO_0060864 GO:0060865 biolink:BiologicalProcess obsolete negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway OBSOLETE. The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission. go.json negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway True http://purl.obolibrary.org/obo/GO_0060865 GO:0060866 biolink:BiologicalProcess leaf abscission The controlled shedding of a leaf. go.json http://purl.obolibrary.org/obo/GO_0060866 GO:0060867 biolink:BiologicalProcess fruit abscission The controlled shedding of a fruit. go.json http://purl.obolibrary.org/obo/GO_0060867 GO:0060868 biolink:BiologicalProcess obsolete regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction OBSOLETE. Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission. go.json True http://purl.obolibrary.org/obo/GO_0060868 GO:0060869 biolink:BiologicalProcess obsolete transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission. go.json transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission True http://purl.obolibrary.org/obo/GO_0060869 GO:0045251 biolink:CellularComponent electron transfer flavoprotein complex A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system. go.json ETF complex http://purl.obolibrary.org/obo/GO_0045251 goslim_pir GO:0045252 biolink:CellularComponent oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). go.json dihydrolipoamide S-succinyltransferase complex http://purl.obolibrary.org/obo/GO_0045252 goslim_pir GO:0045250 biolink:CellularComponent cytosolic pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. go.json pyruvate dehydrogenase complex (lipoamide) http://purl.obolibrary.org/obo/GO_0045250 GO:1901989 biolink:BiologicalProcess positive regulation of cell cycle phase transition Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. go.json activation of cell cycle phase transition|activation of cell cycle transition|positive regulation of cell cycle transition|up regulation of cell cycle phase transition|up regulation of cell cycle transition|up-regulation of cell cycle phase transition|up-regulation of cell cycle transition|upregulation of cell cycle phase transition|upregulation of cell cycle transition http://purl.obolibrary.org/obo/GO_1901989 GO:1901987 biolink:BiologicalProcess regulation of cell cycle phase transition Any process that modulates the frequency, rate or extent of cell cycle phase transition. go.json cell cycle control|regulation of cell cycle transition http://purl.obolibrary.org/obo/GO_1901987 GO:1901988 biolink:BiologicalProcess negative regulation of cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. go.json down regulation of cell cycle phase transition|down regulation of cell cycle transition|down-regulation of cell cycle phase transition|down-regulation of cell cycle transition|downregulation of cell cycle phase transition|downregulation of cell cycle transition|inhibition of cell cycle phase transition|inhibition of cell cycle transition|negative regulation of cell cycle transition http://purl.obolibrary.org/obo/GO_1901988 GO:1901985 biolink:BiologicalProcess positive regulation of protein acetylation Any process that activates or increases the frequency, rate or extent of protein acetylation. go.json activation of protein acetylation|activation of protein amino acid acetylation|positive regulation of protein amino acid acetylation|up regulation of protein acetylation|up regulation of protein amino acid acetylation|up-regulation of protein acetylation|up-regulation of protein amino acid acetylation|upregulation of protein acetylation|upregulation of protein amino acid acetylation http://purl.obolibrary.org/obo/GO_1901985 GO:0045259 biolink:CellularComponent proton-transporting ATP synthase complex A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. go.json F1-F0 complex|hydrogen-translocating F-type ATPase complex|hydrogen-transporting ATP synthase complex|proton-transporting F-type ATPase complex http://purl.obolibrary.org/obo/GO_0045259 GO:1901986 biolink:BiologicalProcess response to ketamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1901986 GO:1901983 biolink:BiologicalProcess regulation of protein acetylation Any process that modulates the frequency, rate or extent of protein acetylation. go.json regulation of protein amino acid acetylation http://purl.obolibrary.org/obo/GO_1901983 GO:0045257 biolink:CellularComponent succinate dehydrogenase complex (ubiquinone) The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. go.json http://purl.obolibrary.org/obo/GO_0045257 GO:1901984 biolink:BiologicalProcess negative regulation of protein acetylation Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. go.json down regulation of protein acetylation|down regulation of protein amino acid acetylation|down-regulation of protein acetylation|down-regulation of protein amino acid acetylation|downregulation of protein acetylation|downregulation of protein amino acid acetylation|inhibition of protein acetylation|inhibition of protein amino acid acetylation|negative regulation of protein amino acid acetylation http://purl.obolibrary.org/obo/GO_1901984 GO:0045258 biolink:CellularComponent plasma membrane succinate dehydrogenase complex (ubiquinone) The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. go.json http://purl.obolibrary.org/obo/GO_0045258 GO:1901981 biolink:MolecularActivity phosphatidylinositol phosphate binding Binding to phosphatidylinositol phosphate. go.json http://purl.obolibrary.org/obo/GO_1901981 GO:0045255 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045255 GO:1901982 biolink:MolecularActivity maltose binding Binding to maltose. go.json http://purl.obolibrary.org/obo/GO_1901982 GO:0045256 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045256 GO:0060890 biolink:BiologicalProcess limb spinous cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell. go.json http://purl.obolibrary.org/obo/GO_0060890 GO:0045253 biolink:CellularComponent pyruvate dehydrogenase (lipoamide) phosphatase complex A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. go.json http://purl.obolibrary.org/obo/GO_0045253 goslim_pir GO:1901980 biolink:BiologicalProcess positive regulation of inward rectifier potassium channel activity Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity. go.json activation of Kir channel activity|activation of inward rectifier potassium channel activity|positive regulation of Kir channel activity|up regulation of Kir channel activity|up regulation of inward rectifier potassium channel activity|up-regulation of Kir channel activity|up-regulation of inward rectifier potassium channel activity|upregulation of Kir channel activity|upregulation of inward rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_1901980 gocheck_do_not_annotate GO:0060891 biolink:BiologicalProcess limb granular cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell. go.json http://purl.obolibrary.org/obo/GO_0060891 GO:0045254 biolink:CellularComponent pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Wikipedia:Pyruvate_dehydrogenase_complex go.json dihydrolipoyl dehydrogenase complex|pyruvate dehydrogenase complex (lipoamide) http://purl.obolibrary.org/obo/GO_0045254 goslim_pir GO:0060892 biolink:BiologicalProcess limb basal epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0060892 GO:0060893 biolink:BiologicalProcess limb granular cell fate specification The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0060893 GO:0060894 biolink:BiologicalProcess limb spinous cell fate specification The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0060894 GO:0060895 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord. go.json retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning http://purl.obolibrary.org/obo/GO_0060895 GO:0060896 biolink:BiologicalProcess neural plate pattern specification The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. go.json http://purl.obolibrary.org/obo/GO_0060896 GO:0070219 biolink:BiologicalProcess obsolete intracellular sulfide ion homeostasis OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of sulfide ions within a cell. go.json cellular sulfide homeostasis|cellular sulfide ion homeostasis|cellular sulphide homeostasis|cellular sulphide ion homeostasis True http://purl.obolibrary.org/obo/GO_0070219 GO:0060897 biolink:BiologicalProcess neural plate regionalization The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. go.json http://purl.obolibrary.org/obo/GO_0060897 GO:0060898 biolink:BiologicalProcess eye field cell fate commitment involved in camera-type eye formation The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode. go.json http://purl.obolibrary.org/obo/GO_0060898 GO:0070217 biolink:BiologicalProcess transcription factor TFIIIB complex assembly The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex. go.json TFIIIB assembly http://purl.obolibrary.org/obo/GO_0070217 GO:0070218 biolink:BiologicalProcess obsolete sulfide ion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell. go.json sulfide generation|sulfide homeostasis|sulfide production|sulphide generation|sulphide homeostasis|sulphide ion homeostasis|sulphide production True http://purl.obolibrary.org/obo/GO_0070218 GO:0060899 biolink:BiologicalProcess obsolete regulation of transcription involved in eye field cell fate commitment of camera-type eye OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle. go.json True http://purl.obolibrary.org/obo/GO_0060899 GO:0070215 biolink:MolecularActivity obsolete MDM2 binding OBSOLETE. Binding to an isoform of the MDM2 protein, a negative regulator of p53. go.json MDM2 binding True http://purl.obolibrary.org/obo/GO_0070215 GO:0070216 biolink:MolecularActivity obsolete MDM4 binding OBSOLETE. Binding to an isoform of the MDM4 protein, a negative regulator of p53. go.json MDM4 binding|MDMX binding True http://purl.obolibrary.org/obo/GO_0070216 GO:0070213 biolink:BiologicalProcess protein auto-ADP-ribosylation The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. go.json protein amino acid auto-ADP-ribosylation http://purl.obolibrary.org/obo/GO_0070213 gocheck_do_not_annotate GO:0070214 biolink:CellularComponent CSK-GAP-A.p62 complex A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation. go.json http://purl.obolibrary.org/obo/GO_0070214 GO:0070211 biolink:CellularComponent Snt2C complex A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p. go.json http://purl.obolibrary.org/obo/GO_0070211 GO:0070212 biolink:BiologicalProcess protein poly-ADP-ribosylation The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. go.json addition of poly-ADP-ribose to protein|poly(ADP-ribose) addition to protein|protein amino acid poly-ADP-ribosylation|protein poly(ADP-ribose) metabolism|protein poly(ADP-ribose) synthesis http://purl.obolibrary.org/obo/GO_0070212 gocheck_do_not_annotate GO:0070210 biolink:CellularComponent Rpd3L-Expanded complex A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins. go.json Clr6-LE complex http://purl.obolibrary.org/obo/GO_0070210 GO:0045262 biolink:CellularComponent plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species. go.json hydrogen-transporting ATP synthase, F1 sector|proton-transporting ATP synthase complex, catalytic core F(1) http://purl.obolibrary.org/obo/GO_0045262 GO:0045263 biolink:CellularComponent proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. go.json hydrogen-transporting ATP synthase complex, coupling factor F(o)|hydrogen-transporting ATP synthase, F0 sector|hydrogen-transporting ATP synthase, coupling factor CF(0)|proton-transporting ATP synthase complex, coupling factor F(0) http://purl.obolibrary.org/obo/GO_0045263 GO:0045260 biolink:CellularComponent plasma membrane proton-transporting ATP synthase complex A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species. go.json hydrogen-translocating F-type ATPase complex|hydrogen-transporting ATP synthase|plasma membrane hydrogen-translocating F-type ATPase complex|proton-transporting ATP synthase complex http://purl.obolibrary.org/obo/GO_0045260 GO:0045261 biolink:CellularComponent proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. go.json hydrogen-transporting ATP synthase, F1 sector http://purl.obolibrary.org/obo/GO_0045261 GO:1901998 biolink:BiologicalProcess toxin transport The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1901998 GO:1901999 biolink:BiologicalProcess homogentisate metabolic process The chemical reactions and pathways involving homogentisate. go.json homogentisate metabolism http://purl.obolibrary.org/obo/GO_1901999 GO:1901996 biolink:BiologicalProcess regulation of indoleacetic acid biosynthetic process via tryptophan Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan. go.json regulation of IAA biosynthetic process via tryptophan|regulation of indoleacetic acid anabolism via tryptophan|regulation of indoleacetic acid formation via tryptophan|regulation of indoleacetic acid synthesis via tryptophan http://purl.obolibrary.org/obo/GO_1901996 GO:1901997 biolink:BiologicalProcess negative regulation of indoleacetic acid biosynthetic process via tryptophan Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan. go.json down regulation of IAA biosynthetic process via tryptophan|down regulation of indoleacetic acid anabolism via tryptophan|down regulation of indoleacetic acid biosynthetic process via tryptophan|down regulation of indoleacetic acid formation via tryptophan|down regulation of indoleacetic acid synthesis via tryptophan|down-regulation of IAA biosynthetic process via tryptophan|down-regulation of indoleacetic acid anabolism via tryptophan|down-regulation of indoleacetic acid biosynthetic process via tryptophan|down-regulation of indoleacetic acid formation via tryptophan|down-regulation of indoleacetic acid synthesis via tryptophan|downregulation of IAA biosynthetic process via tryptophan|downregulation of indoleacetic acid anabolism via tryptophan|downregulation of indoleacetic acid biosynthetic process via tryptophan|downregulation of indoleacetic acid formation via tryptophan|downregulation of indoleacetic acid synthesis via tryptophan|inhibition of IAA biosynthetic process via tryptophan|inhibition of indoleacetic acid anabolism via tryptophan|inhibition of indoleacetic acid biosynthetic process via tryptophan|inhibition of indoleacetic acid formation via tryptophan|inhibition of indoleacetic acid synthesis via tryptophan|negative regulation of IAA biosynthetic process via tryptophan|negative regulation of indoleacetic acid anabolism via tryptophan|negative regulation of indoleacetic acid formation via tryptophan|negative regulation of indoleacetic acid synthesis via tryptophan http://purl.obolibrary.org/obo/GO_1901997 GO:0045268 biolink:CellularComponent plasma membrane proton-transporting ATP synthase, catalytic core The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species. go.json hydrogen-transporting ATP synthase, catalytic core|proton-transporting ATP synthase, catalytic core http://purl.obolibrary.org/obo/GO_0045268 GO:1901994 biolink:BiologicalProcess negative regulation of meiotic cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition. go.json down regulation of cell cycle transition|down regulation of meiotic cell cycle phase transition|down-regulation of cell cycle transition|down-regulation of meiotic cell cycle phase transition|downregulation of cell cycle transition|downregulation of meiotic cell cycle phase transition|inhibition of cell cycle transition|inhibition of meiotic cell cycle phase transition|negative regulation of cell cycle transition http://purl.obolibrary.org/obo/GO_1901994 GO:0045269 biolink:CellularComponent proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. go.json hydrogen-transporting ATP synthase, central stalk http://purl.obolibrary.org/obo/GO_0045269 GO:1901995 biolink:BiologicalProcess positive regulation of meiotic cell cycle phase transition Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition. go.json activation of cell cycle transition|activation of meiotic cell cycle phase transition|positive regulation of cell cycle transition|up regulation of cell cycle transition|up regulation of meiotic cell cycle phase transition|up-regulation of cell cycle transition|up-regulation of meiotic cell cycle phase transition|upregulation of cell cycle transition|upregulation of meiotic cell cycle phase transition http://purl.obolibrary.org/obo/GO_1901995 GO:0045266 biolink:CellularComponent plasma membrane proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species. go.json hydrogen-transporting ATP synthase, stator stalk|proton-transporting ATP synthase, stator stalk http://purl.obolibrary.org/obo/GO_0045266 GO:1901992 biolink:BiologicalProcess positive regulation of mitotic cell cycle phase transition Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition. go.json activation of mitotic cell cycle phase transition|up regulation of mitotic cell cycle phase transition|up-regulation of mitotic cell cycle phase transition|upregulation of mitotic cell cycle phase transition http://purl.obolibrary.org/obo/GO_1901992 GO:1901993 biolink:BiologicalProcess regulation of meiotic cell cycle phase transition Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition. go.json meiotic cell cycle control|regulation of cell cycle transition http://purl.obolibrary.org/obo/GO_1901993 GO:0045267 biolink:CellularComponent proton-transporting ATP synthase, catalytic core The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. go.json hydrogen-transporting ATP synthase, catalytic core http://purl.obolibrary.org/obo/GO_0045267 GO:0045264 biolink:CellularComponent plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins. go.json hydrogen-transporting ATP synthase, F0 sector|proton-transporting ATP synthase complex, coupling factor F(0)|proton-transporting ATP synthase complex, coupling factor F(o) http://purl.obolibrary.org/obo/GO_0045264 GO:1901990 biolink:BiologicalProcess regulation of mitotic cell cycle phase transition Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition. go.json mitotic cell cycle control http://purl.obolibrary.org/obo/GO_1901990 GO:1901991 biolink:BiologicalProcess negative regulation of mitotic cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition. go.json down regulation of mitotic cell cycle phase transition|down-regulation of mitotic cell cycle phase transition|downregulation of mitotic cell cycle phase transition|inhibition of mitotic cell cycle phase transition http://purl.obolibrary.org/obo/GO_1901991 GO:0045265 biolink:CellularComponent proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core. go.json hydrogen-transporting ATP synthase, stator stalk http://purl.obolibrary.org/obo/GO_0045265 GO:0060880 biolink:BiologicalProcess cell morphogenesis involved in semicircular canal fusion The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion. go.json http://purl.obolibrary.org/obo/GO_0060880 GO:0060881 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060881 GO:0060882 biolink:BiologicalProcess basement membrane disassembly involved in semicircular canal fusion A process that results in the breakdown of the basement membrane that contributes to the process of semicircular canal fusion. go.json basal lamina disassembly involved in semicircular canal fusion http://purl.obolibrary.org/obo/GO_0060882 GO:0060883 biolink:BiologicalProcess obsolete regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication OBSOLETE. Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion. go.json regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication True http://purl.obolibrary.org/obo/GO_0060883 GO:0060884 biolink:BiologicalProcess clearance of cells from fusion plate The morphogenetic process in which cells are removed from the inner loop of a semicircular canal. go.json http://purl.obolibrary.org/obo/GO_0060884 GO:0070208 biolink:BiologicalProcess protein heterotrimerization The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. go.json protein heterotrimer assembly|protein heterotrimer biosynthesis|protein heterotrimer biosynthetic process|protein heterotrimer formation http://purl.obolibrary.org/obo/GO_0070208 GO:0060885 biolink:BiologicalProcess clearance of cells from fusion plate by apoptotic process Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals. go.json clearance of cells from fusion plate by apoptosis http://purl.obolibrary.org/obo/GO_0060885 GO:0070209 biolink:CellularComponent ASTRA complex A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p. go.json http://purl.obolibrary.org/obo/GO_0070209 GO:0060886 biolink:BiologicalProcess clearance of cells from fusion plate by epithelial to mesenchymal transition The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals. go.json http://purl.obolibrary.org/obo/GO_0060886 GO:0070206 biolink:BiologicalProcess protein trimerization The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. go.json protein trimer assembly|protein trimer biosynthesis|protein trimer biosynthetic process|protein trimer formation http://purl.obolibrary.org/obo/GO_0070206 GO:0060887 biolink:BiologicalProcess limb epidermis development The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium. go.json http://purl.obolibrary.org/obo/GO_0060887 GO:0070207 biolink:BiologicalProcess protein homotrimerization The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. go.json protein homotrimer assembly|protein homotrimer biosynthesis|protein homotrimer biosynthetic process|protein homotrimer formation http://purl.obolibrary.org/obo/GO_0070207 GO:0060888 biolink:BiologicalProcess limb epidermis stratification The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis. go.json http://purl.obolibrary.org/obo/GO_0060888 GO:0070204 biolink:MolecularActivity 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2. EC:2.2.1.9|KEGG_REACTION:R08165|MetaCyc:2.5.1.64-RXN|RHEA:25593 go.json MenD|SEPHCHC synthase activity http://purl.obolibrary.org/obo/GO_0070204 GO:0060889 biolink:BiologicalProcess limb basal epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis. go.json http://purl.obolibrary.org/obo/GO_0060889 GO:0070205 biolink:MolecularActivity 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate. EC:4.2.99.20|KEGG_REACTION:R08166|MetaCyc:RXN-9310|RHEA:25597 go.json 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity|6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity|MenH|SHCHC synthase activity|YfbB http://purl.obolibrary.org/obo/GO_0070205 GO:0070202 biolink:BiologicalProcess regulation of establishment of protein localization to chromosome Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. go.json regulation of establishment of protein localisation to chromosome http://purl.obolibrary.org/obo/GO_0070202 GO:0070203 biolink:BiologicalProcess regulation of establishment of protein localization to telomere Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome. go.json regulation of establishment of protein localisation to telomere http://purl.obolibrary.org/obo/GO_0070203 GO:0070200 biolink:BiologicalProcess establishment of protein localization to telomere The directed movement of a protein to a specific location in the telomeric region of a chromosome. go.json establishment of protein localisation to telomere|establishment of protein localization to chromosome, telomeric region http://purl.obolibrary.org/obo/GO_0070200 GO:0070201 biolink:BiologicalProcess regulation of establishment of protein localization Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. go.json regulation of establishment of protein localisation http://purl.obolibrary.org/obo/GO_0070201 GO:0045273 biolink:CellularComponent respiratory chain complex II A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. go.json electron transport complex II http://purl.obolibrary.org/obo/GO_0045273 goslim_pir GO:0045274 biolink:CellularComponent plasma membrane respiratory chain complex II A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species. go.json respiratory chain complex II http://purl.obolibrary.org/obo/GO_0045274 GO:0070230 biolink:BiologicalProcess positive regulation of lymphocyte apoptotic process Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. go.json activation of lymphocyte apoptosis|positive regulation of lymphocyte apoptosis|stimulation of lymphocyte apoptosis|up regulation of lymphocyte apoptosis|up-regulation of lymphocyte apoptosis|upregulation of lymphocyte apoptosis http://purl.obolibrary.org/obo/GO_0070230 GO:0045271 biolink:CellularComponent respiratory chain complex I Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. go.json NADH dehydrogenase (ubiquinone) complex|NADH dehydrogenase complex (ubiquinone)|NADH-Q oxidoreductase complex|electron transport complex I http://purl.obolibrary.org/obo/GO_0045271 GO:0045272 biolink:CellularComponent plasma membrane respiratory chain complex I A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species. go.json NADH dehydrogenase (ubiquinone) complex|respiratory chain complex I http://purl.obolibrary.org/obo/GO_0045272 GO:0045270 biolink:CellularComponent plasma membrane proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species. go.json hydrogen-transporting ATP synthase, central stalk|proton-transporting ATP synthase, central stalk http://purl.obolibrary.org/obo/GO_0045270 GO:0045279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045279 GO:0045277 biolink:CellularComponent respiratory chain complex IV A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). go.json cytochrome c oxidase complex|electron transport complex IV http://purl.obolibrary.org/obo/GO_0045277 goslim_pir GO:0045278 biolink:CellularComponent plasma membrane respiratory chain complex IV A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species. go.json cytochrome c oxidase complex|respiratory chain complex IV http://purl.obolibrary.org/obo/GO_0045278 GO:0045275 biolink:CellularComponent respiratory chain complex III A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase go.json CoQH2-cytochrome c reductase complex|coenzyme Q-cytochrome c oxidoreductase complex|coenzyme Q-cytochrome c reductase complex|complex III|cytochrome bc(1) complex|cytochrome bc1 complex|electron transport complex III|ubiquinol-cytochrome c oxidoreductase complex|ubiquinol-cytochrome-c reductase complex http://purl.obolibrary.org/obo/GO_0045275 goslim_pir GO:0045276 biolink:CellularComponent plasma membrane respiratory chain complex III A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species. go.json plasma membrane coenzyme Q-cytochrome c oxidoreductase complex|plasma membrane coenzyme Q-cytochrome c reductase complex|plasma membrane cytochrome bc1 complex|plasma membrane ubiquinol-cytochrome-c reductase complex|respiratory chain complex III|ubiquinol-cytochrome c oxidoreductase complex|ubiquinol-cytochrome-c reductase complex http://purl.obolibrary.org/obo/GO_0045276 GO:0070239 biolink:BiologicalProcess regulation of activated T cell autonomous cell death Any process that modulates the occurrence or rate of activated T cell autonomous cell death. go.json regulation of ACAD|regulation of activated T cell apoptosis|regulation of activated T lymphocyte autonomous cell death|regulation of activated T-cell autonomous cell death|regulation of activated T-lymphocyte autonomous cell death|regulation of activated cell autonomous cell death http://purl.obolibrary.org/obo/GO_0070239 GO:0070237 biolink:BiologicalProcess positive regulation of activation-induced cell death of T cells Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells. go.json activation of activation-induced cell death of T cells|positive regulation of AICD|positive regulation of activated T cell apoptosis|positive regulation of activation-induced cell death of T lymphocytes|positive regulation of activation-induced cell death of T-cells|positive regulation of activation-induced cell death of T-lymphocytes|positive regulation of antigen-driven apoptosis|stimulation of activation-induced cell death of T cells|up regulation of activation-induced cell death of T cells|up-regulation of activation-induced cell death of T cells|upregulation of activation-induced cell death of T cells http://purl.obolibrary.org/obo/GO_0070237 GO:0070238 biolink:BiologicalProcess activated T cell autonomous cell death A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products. go.json ACAD|activated T cell apoptosis|activated T lymphocyte autonomous cell death|activated T-cell autonomous cell death|activated T-lymphocyte autonomous cell death|activated cell autonomous cell death http://purl.obolibrary.org/obo/GO_0070238 GO:0070235 biolink:BiologicalProcess regulation of activation-induced cell death of T cells Any process that modulates the occurrence or rate of activation-induced cell death of T cells. go.json regulation of AICD|regulation of activated T cell apoptosis|regulation of activation-induced cell death of T lymphocytes|regulation of activation-induced cell death of T-cells|regulation of activation-induced cell death of T-lymphocytes|regulation of antigen-driven apoptosis http://purl.obolibrary.org/obo/GO_0070235 GO:0070236 biolink:BiologicalProcess negative regulation of activation-induced cell death of T cells Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells. go.json down regulation of activation-induced cell death of T cells|down-regulation of activation-induced cell death of T cells|downregulation of activation-induced cell death of T cells|inhibition of activation-induced cell death of T cells|negative regulation of AICD|negative regulation of activated T cell apoptosis|negative regulation of activation-induced cell death of T lymphocytes|negative regulation of activation-induced cell death of T-cells|negative regulation of activation-induced cell death of T-lymphocytes|negative regulation of antigen-driven apoptosis http://purl.obolibrary.org/obo/GO_0070236 GO:0070233 biolink:BiologicalProcess negative regulation of T cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. go.json down regulation of T cell apoptosis|down-regulation of T cell apoptosis|downregulation of T cell apoptosis|inhibition of T cell apoptosis|negative regulation of T cell apoptosis|negative regulation of T lymphocyte apoptosis|negative regulation of T-cell apoptosis|negative regulation of T-lymphocyte apoptosis|negative regulation of programmed cell death of T cells by apoptosis http://purl.obolibrary.org/obo/GO_0070233 GO:0070234 biolink:BiologicalProcess positive regulation of T cell apoptotic process Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. go.json activation of T cell apoptosis|positive regulation of T cell apoptosis|positive regulation of T lymphocyte apoptosis|positive regulation of T-cell apoptosis|positive regulation of T-lymphocyte apoptosis|positive regulation of programmed cell death of T cells by apoptosis|stimulation of T cell apoptosis|up regulation of T cell apoptosis|up-regulation of T cell apoptosis|upregulation of T cell apoptosis http://purl.obolibrary.org/obo/GO_0070234 GO:0070231 biolink:BiologicalProcess T cell apoptotic process Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. go.json T cell apoptosis|T lymphocyte apoptosis|T-cell apoptosis|T-lymphocyte apoptosis|programmed cell death of T cells by apoptosis http://purl.obolibrary.org/obo/GO_0070231 GO:0070232 biolink:BiologicalProcess regulation of T cell apoptotic process Any process that modulates the occurrence or rate of T cell death by apoptotic process. go.json regulation of T cell apoptosis|regulation of T lymphocyte apoptosis|regulation of T-cell apoptosis|regulation of T-lymphocyte apoptosis|regulation of programmed cell death of T cells by apoptosis http://purl.obolibrary.org/obo/GO_0070232 GO:0045284 biolink:CellularComponent plasma membrane fumarate reductase complex A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species. go.json fumarate reductase complex http://purl.obolibrary.org/obo/GO_0045284 GO:0045285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045285 GO:0045282 biolink:CellularComponent plasma membrane succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species. go.json succinate dehydrogenase complex http://purl.obolibrary.org/obo/GO_0045282 GO:0045283 biolink:CellularComponent fumarate reductase complex A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). go.json http://purl.obolibrary.org/obo/GO_0045283 GO:0045280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045280 GO:0045281 biolink:CellularComponent succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones. go.json http://purl.obolibrary.org/obo/GO_0045281 GO:0045288 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045288 GO:0045289 biolink:MolecularActivity luciferin monooxygenase activity Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation. go.json luciferase activity|luciferase monooxygenase activity http://purl.obolibrary.org/obo/GO_0045289 GO:0045286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045286 GO:0045287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045287 GO:0070228 biolink:BiologicalProcess regulation of lymphocyte apoptotic process Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. go.json regulation of lymphocyte apoptosis http://purl.obolibrary.org/obo/GO_0070228 GO:0070229 biolink:BiologicalProcess negative regulation of lymphocyte apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. go.json down regulation of lymphocyte apoptosis|down-regulation of lymphocyte apoptosis|downregulation of lymphocyte apoptosis|inhibition of lymphocyte apoptosis|negative regulation of lymphocyte apoptosis http://purl.obolibrary.org/obo/GO_0070229 GO:0070226 biolink:MolecularActivity sulfur:ferric ion oxidoreductase activity Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+. MetaCyc:SULFFEOXIDO-RXN go.json hydrogen sulfide:ferric ion oxidoreductase http://purl.obolibrary.org/obo/GO_0070226 GO:0070227 biolink:BiologicalProcess lymphocyte apoptotic process Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. go.json lymphocyte apoptosis http://purl.obolibrary.org/obo/GO_0070227 GO:0070224 biolink:MolecularActivity sulfide:quinone oxidoreductase activity Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone. MetaCyc:R17-RXN|RHEA:30239|Reactome:R-HSA-1614665 go.json sulfide-quinone reductase activity|sulphide:quinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0070224 GO:0070225 biolink:MolecularActivity sulfide dehydrogenase activity Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c. EC:1.8.2.3|MetaCyc:RXN-8156|RHEA:30223 go.json flavocytochrome c sulfide dehydrogenase activity|sulphide dehydrogenase activity http://purl.obolibrary.org/obo/GO_0070225 GO:0070222 biolink:BiologicalProcess sulfide oxidation, using sulfide dehydrogenase A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase. MetaCyc:PWY-5274 go.json sulphide oxidation, using sulfide dehydrogenase http://purl.obolibrary.org/obo/GO_0070222 GO:0070223 biolink:BiologicalProcess sulfide oxidation, using sulfur dioxygenase A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase. MetaCyc:PWY-5285 go.json sulphide oxidation, using sulfur dioxygenase http://purl.obolibrary.org/obo/GO_0070223 GO:0070220 biolink:BiologicalProcess aerobic sulfur oxidation A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen. MetaCyc:SULFUROX-PWY go.json aerobic sulphur oxidation http://purl.obolibrary.org/obo/GO_0070220 GO:0070221 biolink:BiologicalProcess sulfide oxidation, using sulfide:quinone oxidoreductase A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase. MetaCyc:P222-PWY go.json sulfide oxidation, using sulfide-quinone reductase|sulphide oxidation, using sulfide:quinone oxidoreductase http://purl.obolibrary.org/obo/GO_0070221 GO:0045295 biolink:MolecularActivity gamma-catenin binding Binding to catenin complex gamma subunit. go.json plakoglobin binding http://purl.obolibrary.org/obo/GO_0045295 GO:0070251 biolink:MolecularActivity pristanate-CoA ligase activity Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA. RHEA:47264|Reactome:R-HSA-389632 go.json pristanate:CoA ligase (AMP-forming)|pristanoyl-CoA ligase activity http://purl.obolibrary.org/obo/GO_0070251 GO:0070252 biolink:BiologicalProcess actin-mediated cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. go.json http://purl.obolibrary.org/obo/GO_0070252 GO:0045296 biolink:MolecularActivity cadherin binding Binding to cadherin, a type I membrane protein involved in cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0045296 GO:0045293 biolink:CellularComponent mRNA editing complex A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes. go.json editosome http://purl.obolibrary.org/obo/GO_0045293 goslim_pir GO:0070250 biolink:CellularComponent mating projection membrane The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone. go.json shmoo membrane http://purl.obolibrary.org/obo/GO_0070250 GO:0045294 biolink:MolecularActivity alpha-catenin binding Binding to catenin complex alpha subunit. go.json http://purl.obolibrary.org/obo/GO_0045294 GO:0045291 biolink:BiologicalProcess mRNA trans splicing, SL addition The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body. go.json nuclear mRNA trans splicing, SL addition|nuclear mRNA trans splicing, spliced leader addition http://purl.obolibrary.org/obo/GO_0045291 GO:0045292 biolink:BiologicalProcess mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. go.json nuclear mRNA cis splicing, via U2-type spliceosome|nuclear mRNA cis splicing, via spliceosome|splicing http://purl.obolibrary.org/obo/GO_0045292 GO:0045290 biolink:MolecularActivity D-arabinose 1-dehydrogenase [NAD(P)+] activity Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. EC:1.1.1.117|MetaCyc:1.1.1.117-RXN go.json D-arabinose:NAD(P)+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0045290 GO:0045299 biolink:BiologicalProcess otolith mineralization The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear. go.json http://purl.obolibrary.org/obo/GO_0045299 GO:0045297 biolink:BiologicalProcess obsolete post-mating behavior OBSOLETE. The specific behavior of an organism following mating. go.json post-mating behaviour True http://purl.obolibrary.org/obo/GO_0045297 GO:0045298 biolink:CellularComponent tubulin complex A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. go.json http://purl.obolibrary.org/obo/GO_0045298 GO:0070259 biolink:MolecularActivity tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA. go.json http://purl.obolibrary.org/obo/GO_0070259 GO:0070257 biolink:BiologicalProcess positive regulation of mucus secretion Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. go.json positive regulation of mucus production http://purl.obolibrary.org/obo/GO_0070257 GO:0070258 biolink:CellularComponent inner membrane pellicle complex A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell. go.json inner membrane complex http://purl.obolibrary.org/obo/GO_0070258 GO:0070255 biolink:BiologicalProcess regulation of mucus secretion Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. go.json regulation of mucus production http://purl.obolibrary.org/obo/GO_0070255 GO:0070256 biolink:BiologicalProcess negative regulation of mucus secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. go.json negative regulation of mucus production http://purl.obolibrary.org/obo/GO_0070256 GO:0070253 biolink:BiologicalProcess somatostatin secretion The regulated release of somatostatin from secretory granules in the D cells of the pancreas. go.json http://purl.obolibrary.org/obo/GO_0070253 GO:0070254 biolink:BiologicalProcess mucus secretion The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. go.json mucus production http://purl.obolibrary.org/obo/GO_0070254 GO:0070240 biolink:BiologicalProcess negative regulation of activated T cell autonomous cell death Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death. go.json down regulation of activated T cell autonomous cell death|down-regulation of activated T cell autonomous cell death|downregulation of activated T cell autonomous cell death|inhibition of activated T cell autonomous cell death|negative regulation of ACAD|negative regulation of activated T cell apoptosis|negative regulation of activated T lymphocyte autonomous cell death|negative regulation of activated T-cell autonomous cell death|negative regulation of activated T-lymphocyte autonomous cell death|negative regulation of activated cell autonomous cell death http://purl.obolibrary.org/obo/GO_0070240 GO:0070241 biolink:BiologicalProcess positive regulation of activated T cell autonomous cell death Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death. go.json activation of activated T cell autonomous cell death|positive regulation of ACAD|positive regulation of activated T cell apoptosis|positive regulation of activated T lymphocyte autonomous cell death|positive regulation of activated T-cell autonomous cell death|positive regulation of activated T-lymphocyte autonomous cell death|positive regulation of activated cell autonomous cell death|stimulation of activated T cell autonomous cell death|up regulation of activated T cell autonomous cell death|up-regulation of activated T cell autonomous cell death|upregulation of activated T cell autonomous cell death http://purl.obolibrary.org/obo/GO_0070241 GO:0070248 biolink:BiologicalProcess negative regulation of natural killer cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process. go.json down regulation of natural killer cell apoptosis|down-regulation of natural killer cell apoptosis|downregulation of natural killer cell apoptosis|inhibition of natural killer cell apoptosis|negative regulation of NK cell apoptosis|negative regulation of natural killer cell apoptosis http://purl.obolibrary.org/obo/GO_0070248 GO:0070249 biolink:BiologicalProcess positive regulation of natural killer cell apoptotic process Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process. go.json activation of natural killer cell apoptosis|positive regulation of NK cell apoptosis|positive regulation of natural killer cell apoptosis|stimulation of natural killer cell apoptosis|up regulation of natural killer cell apoptosis|up-regulation of natural killer cell apoptosis|upregulation of natural killer cell apoptosis http://purl.obolibrary.org/obo/GO_0070249 GO:0070246 biolink:BiologicalProcess natural killer cell apoptotic process Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation. go.json NK cell apoptosis|natural killer cell apoptosis http://purl.obolibrary.org/obo/GO_0070246 GO:0070247 biolink:BiologicalProcess regulation of natural killer cell apoptotic process Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process. go.json regulation of NK cell apoptosis|regulation of natural killer cell apoptosis http://purl.obolibrary.org/obo/GO_0070247 GO:0070244 biolink:BiologicalProcess negative regulation of thymocyte apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process. go.json down regulation of thymocyte apoptosis|down-regulation of thymocyte apoptosis|downregulation of thymocyte apoptosis|inhibition of thymocyte apoptosis|negative regulation of immature T cell apoptosis|negative regulation of thymocyte apoptosis http://purl.obolibrary.org/obo/GO_0070244 GO:0070245 biolink:BiologicalProcess positive regulation of thymocyte apoptotic process Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process. go.json activation of thymocyte apoptosis|positive regulation of immature T cell apoptosis|positive regulation of thymocyte apoptosis|stimulation of thymocyte apoptosis|up regulation of thymocyte apoptosis|up-regulation of thymocyte apoptosis|upregulation of thymocyte apoptosis http://purl.obolibrary.org/obo/GO_0070245 GO:0070242 biolink:BiologicalProcess thymocyte apoptotic process Any apoptotic process in a thymocyte, an immature T cell located in the thymus. go.json immature T cell apoptosis|thymocyte apoptosis http://purl.obolibrary.org/obo/GO_0070242 GO:0070243 biolink:BiologicalProcess regulation of thymocyte apoptotic process Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. go.json regulation of immature T cell apoptosis|regulation of thymocyte apoptosis http://purl.obolibrary.org/obo/GO_0070243 GO:0045402 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045402 GO:0045403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045403 GO:0045400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045400 GO:0045401 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045401 GO:0045408 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045408 GO:0045409 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045409 GO:0045406 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045406 GO:0045407 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045407 GO:0045404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045404 GO:0045405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045405 GO:1901905 biolink:BiologicalProcess response to tamsulosin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus. go.json http://purl.obolibrary.org/obo/GO_1901905 GO:1901906 biolink:BiologicalProcess diadenosine pentaphosphate metabolic process The chemical reactions and pathways involving diadenosine pentaphosphate. go.json diadenosine pentaphosphate metabolism|diadenosyl pentaphosphate metabolic process|diadenosyl pentaphosphate metabolism http://purl.obolibrary.org/obo/GO_1901906 GO:1901903 biolink:BiologicalProcess tyrocidine catabolic process The chemical reactions and pathways resulting in the breakdown of tyrocidine. go.json tyrocidine breakdown|tyrocidine catabolism|tyrocidine degradation http://purl.obolibrary.org/obo/GO_1901903 GO:1901904 biolink:BiologicalProcess tyrocidine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrocidine. go.json tyrocidine anabolism|tyrocidine biosynthesis|tyrocidine formation|tyrocidine synthesis http://purl.obolibrary.org/obo/GO_1901904 GO:1901901 biolink:BiologicalProcess regulation of protein localization to cell division site involved in cytokinesis Any regulation of protein localization to cell division site that is involved in cytokinesis. go.json regulation of protein localisation to cell division site involved in cytokinesis http://purl.obolibrary.org/obo/GO_1901901 GO:1901902 biolink:BiologicalProcess tyrocidine metabolic process The chemical reactions and pathways involving tyrocidine. go.json tyrocidine metabolism http://purl.obolibrary.org/obo/GO_1901902 GO:1901900 biolink:BiologicalProcess regulation of protein localization to cell division site Any process that modulates the frequency, rate or extent of protein localization to cell division site. go.json regulation of protein localisation to cell division site http://purl.obolibrary.org/obo/GO_1901900 GO:0045413 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045413 GO:0045414 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045414 GO:0045411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045411 GO:0045412 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045412 GO:0045410 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045410 GO:0045419 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045419 GO:0045417 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045417 GO:0045418 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045418 GO:0045415 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045415 GO:0045416 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045416 GO:1901909 biolink:BiologicalProcess diadenosine hexaphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate. go.json diadenosine hexaphosphate catabolism|diadenosyl hexaphosphate breakdown|diadenosyl hexaphosphate catabolic process|diadenosyl hexaphosphate catabolism|diadenosyl hexaphosphate degradation http://purl.obolibrary.org/obo/GO_1901909 GO:1901907 biolink:BiologicalProcess diadenosine pentaphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate. go.json diadenosine pentaphosphate catabolism|diadenosyl pentaphosphate breakdown|diadenosyl pentaphosphate catabolic process|diadenosyl pentaphosphate catabolism|diadenosyl pentaphosphate degradation http://purl.obolibrary.org/obo/GO_1901907 GO:1901908 biolink:BiologicalProcess diadenosine hexaphosphate metabolic process The chemical reactions and pathways involving diadenosine hexaphosphate. go.json diadenosine hexaphosphate metabolism|diadenosyl hexaphosphate metabolic process|diadenosyl hexaphosphate metabolism http://purl.obolibrary.org/obo/GO_1901908 GO:1901916 biolink:MolecularActivity obsolete protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis OBSOLETE. Any protein kinase activity that is involved in regulation of protein localization to cell division site involved in cytokinesis. go.json protamine kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis|protamine kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis|protein kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis True http://purl.obolibrary.org/obo/GO_1901916 GO:1901917 biolink:BiologicalProcess regulation of exoribonuclease activity Any process that modulates the frequency, rate or extent of exoribonuclease activity. go.json http://purl.obolibrary.org/obo/GO_1901917 gocheck_do_not_annotate GO:1901914 biolink:BiologicalProcess negative regulation of capsule organization Any process that stops, prevents or reduces the frequency, rate or extent of capsule organization. go.json down regulation of capsule organisation|down regulation of capsule organization|down regulation of capsule organization and biogenesis|down-regulation of capsule organisation|down-regulation of capsule organization|down-regulation of capsule organization and biogenesis|downregulation of capsule organisation|downregulation of capsule organization|downregulation of capsule organization and biogenesis|inhibition of capsule organisation|inhibition of capsule organization|inhibition of capsule organization and biogenesis|negative regulation of capsule organisation|negative regulation of capsule organization and biogenesis http://purl.obolibrary.org/obo/GO_1901914 GO:1901915 biolink:BiologicalProcess positive regulation of capsule organization Any process that activates or increases the frequency, rate or extent of capsule organization. go.json activation of capsule organisation|activation of capsule organization|activation of capsule organization and biogenesis|positive regulation of capsule organisation|positive regulation of capsule organization and biogenesis|up regulation of capsule organisation|up regulation of capsule organization|up regulation of capsule organization and biogenesis|up-regulation of capsule organisation|up-regulation of capsule organization|up-regulation of capsule organization and biogenesis|upregulation of capsule organisation|upregulation of capsule organization|upregulation of capsule organization and biogenesis http://purl.obolibrary.org/obo/GO_1901915 GO:1901912 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1901912 GO:1901913 biolink:BiologicalProcess regulation of capsule organization Any process that modulates the frequency, rate or extent of capsule organization. go.json regulation of capsule organisation|regulation of capsule organization and biogenesis http://purl.obolibrary.org/obo/GO_1901913 GO:1901910 biolink:BiologicalProcess adenosine 5'-(hexahydrogen pentaphosphate) metabolic process The chemical reactions and pathways involving adenosine 5'-(hexahydrogen pentaphosphate). go.json adenosine 5'-(hexahydrogen pentaphosphate) metabolism http://purl.obolibrary.org/obo/GO_1901910 GO:1901911 biolink:BiologicalProcess adenosine 5'-(hexahydrogen pentaphosphate) catabolic process The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate). go.json adenosine 5'-(hexahydrogen pentaphosphate) breakdown|adenosine 5'-(hexahydrogen pentaphosphate) catabolism|adenosine 5'-(hexahydrogen pentaphosphate) degradation http://purl.obolibrary.org/obo/GO_1901911 GO:0045424 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045424 GO:0045425 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045425 GO:0045422 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045422 GO:0045423 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045423 GO:0045420 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045420 GO:0045421 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045421 GO:0045428 biolink:BiologicalProcess regulation of nitric oxide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. go.json regulation of nitric oxide anabolism|regulation of nitric oxide biosynthesis|regulation of nitric oxide formation|regulation of nitric oxide synthesis http://purl.obolibrary.org/obo/GO_0045428 GO:0045429 biolink:BiologicalProcess positive regulation of nitric oxide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. go.json activation of nitric oxide biosynthetic process|positive regulation of nitric oxide anabolism|positive regulation of nitric oxide biosynthesis|positive regulation of nitric oxide formation|positive regulation of nitric oxide synthesis|stimulation of nitric oxide biosynthetic process|up regulation of nitric oxide biosynthetic process|up-regulation of nitric oxide biosynthetic process|upregulation of nitric oxide biosynthetic process http://purl.obolibrary.org/obo/GO_0045429 GO:0045426 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045426 GO:0045427 biolink:BiologicalProcess obsolete enzyme active site formation via (phospho-5'-guanosine)-L-histidine OBSOLETE. The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine. go.json True http://purl.obolibrary.org/obo/GO_0045427 GO:1901918 biolink:BiologicalProcess negative regulation of exoribonuclease activity Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity. go.json down regulation of exoribonuclease activity|down-regulation of exoribonuclease activity|downregulation of exoribonuclease activity|inhibition of exoribonuclease activity http://purl.obolibrary.org/obo/GO_1901918 gocheck_do_not_annotate GO:1901919 biolink:BiologicalProcess positive regulation of exoribonuclease activity Any process that activates or increases the frequency, rate or extent of exoribonuclease activity. go.json activation of exoribonuclease activity|up regulation of exoribonuclease activity|up-regulation of exoribonuclease activity|upregulation of exoribonuclease activity http://purl.obolibrary.org/obo/GO_1901919 gocheck_do_not_annotate GO:1901927 biolink:BiologicalProcess cadinene catabolic process The chemical reactions and pathways resulting in the breakdown of cadinene. go.json cadinene breakdown|cadinene catabolism|cadinene degradation http://purl.obolibrary.org/obo/GO_1901927 GO:1901928 biolink:BiologicalProcess cadinene biosynthetic process The chemical reactions and pathways resulting in the formation of cadinene. go.json cadinene anabolism|cadinene biosynthesis|cadinene formation|cadinene synthesis http://purl.obolibrary.org/obo/GO_1901928 GO:1901925 biolink:BiologicalProcess negative regulation of protein import into nucleus during spindle assembly checkpoint Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). go.json KTIP|Kap121p transport inhibitory pathway|negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_1901925 GO:1901926 biolink:BiologicalProcess cadinene metabolic process The chemical reactions and pathways involving cadinene. go.json cadinene metabolism http://purl.obolibrary.org/obo/GO_1901926 GO:1901923 biolink:BiologicalProcess negative regulation of sclerotium development Any process that stops, prevents or reduces the frequency, rate or extent of sclerotium development. go.json down regulation of sclerotium development|down-regulation of sclerotium development|downregulation of sclerotium development|inhibition of sclerotium development http://purl.obolibrary.org/obo/GO_1901923 GO:1901924 biolink:BiologicalProcess positive regulation of sclerotium development Any process that activates or increases the frequency, rate or extent of sclerotium development. go.json activation of sclerotium development|up regulation of sclerotium development|up-regulation of sclerotium development|upregulation of sclerotium development http://purl.obolibrary.org/obo/GO_1901924 GO:1901921 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain that is involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex. go.json CTD domain phosphorylation of RNA polymerase II involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex True http://purl.obolibrary.org/obo/GO_1901921 GO:1901922 biolink:BiologicalProcess regulation of sclerotium development Any process that modulates the frequency, rate or extent of sclerotium development. go.json http://purl.obolibrary.org/obo/GO_1901922 GO:0045435 biolink:MolecularActivity lycopene epsilon cyclase activity Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene). go.json lycopene cyclase http://purl.obolibrary.org/obo/GO_0045435 GO:1901920 biolink:BiologicalProcess peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity Any peptidyl-tyrosine dephosphorylation that is involved in activation of protein kinase activity. go.json peptidyl-tyrosine dephosphorylation involved in protein kinase activation http://purl.obolibrary.org/obo/GO_1901920 gocheck_do_not_annotate GO:0045436 biolink:MolecularActivity lycopene beta cyclase activity Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively. MetaCyc:RXN1F-150|RHEA:32219 go.json crtL|lycopene cyclase http://purl.obolibrary.org/obo/GO_0045436 GO:0045433 biolink:BiologicalProcess male courtship behavior, veined wing generated song production The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song. go.json male courtship behavior, song production|male courtship behaviour, song production|male courtship behaviour, veined wing generated song production http://purl.obolibrary.org/obo/GO_0045433 GO:0045434 biolink:BiologicalProcess negative regulation of female receptivity, post-mating Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating. go.json down regulation of female receptivity, post-mating|down-regulation of female receptivity, post-mating|downregulation of female receptivity, post-mating|inhibition of female receptivity, post-mating http://purl.obolibrary.org/obo/GO_0045434 GO:0045431 biolink:MolecularActivity flavonol synthase activity Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O. EC:1.14.20.6|RHEA:21088 go.json FLS activity|dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity|flavonoid 2-oxoglutarate-dependent dioxygenase activity http://purl.obolibrary.org/obo/GO_0045431 GO:0045432 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045432 GO:0045430 biolink:MolecularActivity chalcone isomerase activity Catalysis of the reaction: a chalcone = a flavanone. EC:5.5.1.6|MetaCyc:CHALCONE-ISOMERASE-RXN go.json chalcone--flavonone isomerase activity|chalcone-flavanone isomerase activity|flavanone lyase (decyclizing) http://purl.obolibrary.org/obo/GO_0045430 GO:0045439 biolink:MolecularActivity isopenicillin-N epimerase activity Catalysis of the reaction: isopenicillin N = penicillin N. EC:5.1.1.17|KEGG_REACTION:R04147|MetaCyc:5.1.1.17-RXN|RHEA:20033 go.json isopenicillin N epimerase activity|penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity http://purl.obolibrary.org/obo/GO_0045439 GO:0045437 biolink:MolecularActivity uridine nucleosidase activity Catalysis of the reaction: H2O + uridine = ribofuranose + uracil. EC:3.2.2.3|KEGG_REACTION:R01080|MetaCyc:URIDINE-NUCLEOSIDASE-RXN|RHEA:15577 go.json uridine hydrolase activity|uridine ribohydrolase activity http://purl.obolibrary.org/obo/GO_0045437 GO:0045438 biolink:MolecularActivity delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol. go.json ACV synthetase activity http://purl.obolibrary.org/obo/GO_0045438 GO:1901929 biolink:BiologicalProcess alpha-copaene metabolic process The chemical reactions and pathways involving alpha-copaene. go.json alpha-copaene metabolism http://purl.obolibrary.org/obo/GO_1901929 GO:1901938 biolink:BiologicalProcess (-)-exo-alpha-bergamotene metabolic process The chemical reactions and pathways involving (-)-exo-alpha-bergamotene. go.json (-)-exo-alpha-bergamotene metabolism http://purl.obolibrary.org/obo/GO_1901938 GO:1901939 biolink:BiologicalProcess (-)-exo-alpha-bergamotene catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-exo-alpha-bergamotene. go.json (-)-exo-alpha-bergamotene breakdown|(-)-exo-alpha-bergamotene catabolism|(-)-exo-alpha-bergamotene degradation http://purl.obolibrary.org/obo/GO_1901939 GO:1901936 biolink:BiologicalProcess beta-caryophyllene catabolic process The chemical reactions and pathways resulting in the breakdown of beta-caryophyllene. go.json beta-caryophyllene breakdown|beta-caryophyllene catabolism|beta-caryophyllene degradation http://purl.obolibrary.org/obo/GO_1901936 GO:1901937 biolink:BiologicalProcess beta-caryophyllene biosynthetic process The chemical reactions and pathways resulting in the formation of beta-caryophyllene. go.json beta-caryophyllene anabolism|beta-caryophyllene biosynthesis|beta-caryophyllene formation|beta-caryophyllene synthesis http://purl.obolibrary.org/obo/GO_1901937 GO:1901934 biolink:BiologicalProcess bicyclogermacrene biosynthetic process The chemical reactions and pathways resulting in the formation of bicyclogermacrene. go.json bicyclogermacrene anabolism|bicyclogermacrene biosynthesis|bicyclogermacrene formation|bicyclogermacrene synthesis http://purl.obolibrary.org/obo/GO_1901934 GO:1901935 biolink:BiologicalProcess beta-caryophyllene metabolic process The chemical reactions and pathways involving beta-caryophyllene. go.json beta-caryophyllene metabolism http://purl.obolibrary.org/obo/GO_1901935 GO:1901932 biolink:BiologicalProcess bicyclogermacrene metabolic process The chemical reactions and pathways involving bicyclogermacrene. go.json bicyclogermacrene metabolism http://purl.obolibrary.org/obo/GO_1901932 GO:1901933 biolink:BiologicalProcess bicyclogermacrene catabolic process The chemical reactions and pathways resulting in the breakdown of bicyclogermacrene. go.json bicyclogermacrene breakdown|bicyclogermacrene catabolism|bicyclogermacrene degradation http://purl.obolibrary.org/obo/GO_1901933 GO:1901930 biolink:BiologicalProcess alpha-copaene catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-copaene. go.json alpha-copaene breakdown|alpha-copaene catabolism|alpha-copaene degradation http://purl.obolibrary.org/obo/GO_1901930 GO:0045446 biolink:BiologicalProcess endothelial cell differentiation The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. go.json http://purl.obolibrary.org/obo/GO_0045446 GO:0045447 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045447 GO:1901931 biolink:BiologicalProcess alpha-copaene biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-copaene. go.json alpha-copaene anabolism|alpha-copaene biosynthesis|alpha-copaene formation|alpha-copaene synthesis http://purl.obolibrary.org/obo/GO_1901931 GO:0045444 biolink:BiologicalProcess fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. go.json adipocyte cell differentiation|adipocyte differentiation|adipogenesis|adipose cell differentiation http://purl.obolibrary.org/obo/GO_0045444 GO:0045445 biolink:BiologicalProcess myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. go.json myoblast cell differentiation http://purl.obolibrary.org/obo/GO_0045445 GO:0045442 biolink:MolecularActivity deacetoxycephalosporin-C hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate. EC:1.14.11.26|KEGG_REACTION:R05229|MetaCyc:1.14.11.26-RXN|RHEA:16805 go.json 3'-methylcephem hydroxylase activity|DACS|DAOC hydroxylase activity|beta-lactam hydroxylase activity|deacetoxycephalosporin C hydroxylase activity|deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|deacetylcephalosporin C synthase activity http://purl.obolibrary.org/obo/GO_0045442 GO:0045443 biolink:BiologicalProcess juvenile hormone secretion The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. go.json http://purl.obolibrary.org/obo/GO_0045443 GO:0045440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045440 GO:0045441 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045441 GO:0045448 biolink:BiologicalProcess mitotic cell cycle, embryonic The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo. go.json http://purl.obolibrary.org/obo/GO_0045448 GO:0045449 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045449 GO:1901949 biolink:BiologicalProcess 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate. go.json 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate anabolism|5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthesis|5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate formation|5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate synthesis http://purl.obolibrary.org/obo/GO_1901949 GO:0045450 biolink:BiologicalProcess bicoid mRNA localization Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis. go.json bicoid mRNA localisation|establishment and maintenance of bicoid mRNA localization http://purl.obolibrary.org/obo/GO_0045450 GO:1901947 biolink:BiologicalProcess 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process The chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate. go.json 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism http://purl.obolibrary.org/obo/GO_1901947 GO:1901948 biolink:BiologicalProcess 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate. go.json 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate breakdown|5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolism|5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate degradation http://purl.obolibrary.org/obo/GO_1901948 GO:1901945 biolink:BiologicalProcess miltiradiene catabolic process The chemical reactions and pathways resulting in the breakdown of miltiradiene. go.json miltiradiene breakdown|miltiradiene catabolism|miltiradiene degradation http://purl.obolibrary.org/obo/GO_1901945 GO:1901946 biolink:BiologicalProcess miltiradiene biosynthetic process The chemical reactions and pathways resulting in the formation of miltiradiene. go.json miltiradiene anabolism|miltiradiene biosynthesis|miltiradiene formation|miltiradiene synthesis http://purl.obolibrary.org/obo/GO_1901946 GO:1901943 biolink:BiologicalProcess (+)-epi-alpha-bisabolol biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-epi-alpha-bisabolol. go.json (+)-epi-alpha-bisabolol anabolism|(+)-epi-alpha-bisabolol biosynthesis|(+)-epi-alpha-bisabolol formation|(+)-epi-alpha-bisabolol synthesis http://purl.obolibrary.org/obo/GO_1901943 GO:1901944 biolink:BiologicalProcess miltiradiene metabolic process The chemical reactions and pathways involving miltiradiene. go.json miltiradiene metabolism http://purl.obolibrary.org/obo/GO_1901944 GO:1901941 biolink:BiologicalProcess (+)-epi-alpha-bisabolol metabolic process The chemical reactions and pathways involving (+)-epi-alpha-bisabolol. go.json (+)-epi-alpha-bisabolol metabolism http://purl.obolibrary.org/obo/GO_1901941 GO:0045457 biolink:BiologicalProcess ecdysteroid secretion The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. go.json http://purl.obolibrary.org/obo/GO_0045457 GO:0045458 biolink:BiologicalProcess recombination within rDNA repeats Genetic recombination within the DNA of the genes coding for ribosomal RNA. go.json recombination within ribosomal DNA repeats http://purl.obolibrary.org/obo/GO_0045458 GO:1901942 biolink:BiologicalProcess (+)-epi-alpha-bisabolol catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-epi-alpha-bisabolol. go.json (+)-epi-alpha-bisabolol breakdown|(+)-epi-alpha-bisabolol catabolism|(+)-epi-alpha-bisabolol degradation http://purl.obolibrary.org/obo/GO_1901942 GO:0045455 biolink:BiologicalProcess ecdysteroid metabolic process The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. go.json ecdysteroid metabolism http://purl.obolibrary.org/obo/GO_0045455 GO:1901940 biolink:BiologicalProcess (-)-exo-alpha-bergamotene biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene. go.json (-)-exo-alpha-bergamotene anabolism|(-)-exo-alpha-bergamotene biosynthesis|(-)-exo-alpha-bergamotene formation|(-)-exo-alpha-bergamotene synthesis http://purl.obolibrary.org/obo/GO_1901940 GO:0045456 biolink:BiologicalProcess ecdysteroid biosynthetic process The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. go.json ecdysteroid anabolism|ecdysteroid biosynthesis|ecdysteroid formation|ecdysteroid synthesis http://purl.obolibrary.org/obo/GO_0045456 GO:0045453 biolink:BiologicalProcess bone resorption The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. Wikipedia:Bone_resorption go.json http://purl.obolibrary.org/obo/GO_0045453 GO:0045454 biolink:BiologicalProcess cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. Wikipedia:Redox go.json regulation of cell redox homeostasis|regulation of redox homeostasis http://purl.obolibrary.org/obo/GO_0045454 goslim_drosophila|goslim_metagenomics GO:0045451 biolink:BiologicalProcess pole plasm oskar mRNA localization Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. go.json establishment and maintenance of oskar mRNA localization in pole plasm|establishment and maintenance of pole plasm oskar mRNA localization|oocyte pole plasm oskar mRNA localization|pole plasm oskar mRNA localisation http://purl.obolibrary.org/obo/GO_0045451 GO:0045452 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045452 GO:0070419 biolink:CellularComponent nonhomologous end joining complex A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. go.json NHEJ complex|non-homologous end joining complex http://purl.obolibrary.org/obo/GO_0070419 GO:0070417 biolink:BiologicalProcess cellular response to cold Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. go.json cellular response to cold stress http://purl.obolibrary.org/obo/GO_0070417 GO:0070418 biolink:CellularComponent DNA-dependent protein kinase complex A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku. go.json DNA-PK complex|DNA-PK-Ku antigen complex|DNA-dependent protein kinase, DNA-end-binding complex http://purl.obolibrary.org/obo/GO_0070418 GO:0045459 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide. RESID:AA0326 go.json iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide http://purl.obolibrary.org/obo/GO_0045459 gocheck_do_not_annotate GO:0070415 biolink:BiologicalProcess trehalose metabolism in response to cold stress The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. go.json trehalose metabolic process involved in response to cold stress http://purl.obolibrary.org/obo/GO_0070415 GO:0070416 biolink:BiologicalProcess trehalose metabolism in response to water deprivation The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water. go.json trehalose metabolic process involved in response to water deprivation http://purl.obolibrary.org/obo/GO_0070416 GO:0070413 biolink:BiologicalProcess trehalose metabolism in response to stress The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress. go.json trehalose metabolic process involved in response to stress http://purl.obolibrary.org/obo/GO_0070413 GO:0070414 biolink:BiologicalProcess trehalose metabolism in response to heat stress The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. go.json trehalose metabolic process involved in response to heat stress http://purl.obolibrary.org/obo/GO_0070414 GO:0070411 biolink:MolecularActivity I-SMAD binding Binding to an inhibitory SMAD signaling protein. go.json http://purl.obolibrary.org/obo/GO_0070411 GO:0070412 biolink:MolecularActivity R-SMAD binding Binding to a receptor-regulated SMAD signaling protein. go.json pathway restricted SMAD binding|pathway-restricted SMAD binding|receptor regulated SMAD binding|receptor-regulated SMAD binding http://purl.obolibrary.org/obo/GO_0070412 GO:0070410 biolink:MolecularActivity co-SMAD binding Binding to a common mediator SMAD signaling protein. go.json common mediator SMAD binding|common partner SMAD binding|common-mediator SMAD binding|common-partner SMAD binding http://purl.obolibrary.org/obo/GO_0070410 GO:0045460 biolink:BiologicalProcess sterigmatocystin metabolic process The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. go.json sterigmatocystin metabolism http://purl.obolibrary.org/obo/GO_0045460 GO:0045461 biolink:BiologicalProcess sterigmatocystin biosynthetic process The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. go.json sterigmatocystin anabolism|sterigmatocystin biosynthesis|sterigmatocystin formation|sterigmatocystin synthesis http://purl.obolibrary.org/obo/GO_0045461 GO:1901958 biolink:BiologicalProcess negative regulation of cutin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of cutin biosynthetic process. go.json down regulation of cutin anabolism|down regulation of cutin biosynthesis|down regulation of cutin biosynthetic process|down regulation of cutin formation|down regulation of cutin synthesis|down-regulation of cutin anabolism|down-regulation of cutin biosynthesis|down-regulation of cutin biosynthetic process|down-regulation of cutin formation|down-regulation of cutin synthesis|downregulation of cutin anabolism|downregulation of cutin biosynthesis|downregulation of cutin biosynthetic process|downregulation of cutin formation|downregulation of cutin synthesis|inhibition of cutin anabolism|inhibition of cutin biosynthesis|inhibition of cutin biosynthetic process|inhibition of cutin formation|inhibition of cutin synthesis|negative regulation of cutin anabolism|negative regulation of cutin biosynthesis|negative regulation of cutin formation|negative regulation of cutin synthesis http://purl.obolibrary.org/obo/GO_1901958 GO:1901959 biolink:BiologicalProcess positive regulation of cutin biosynthetic process Any process that activates or increases the frequency, rate or extent of cutin biosynthetic process. go.json activation of cutin anabolism|activation of cutin biosynthesis|activation of cutin biosynthetic process|activation of cutin formation|activation of cutin synthesis|positive regulation of cutin anabolism|positive regulation of cutin biosynthesis|positive regulation of cutin formation|positive regulation of cutin synthesis|up regulation of cutin anabolism|up regulation of cutin biosynthesis|up regulation of cutin biosynthetic process|up regulation of cutin formation|up regulation of cutin synthesis|up-regulation of cutin anabolism|up-regulation of cutin biosynthesis|up-regulation of cutin biosynthetic process|up-regulation of cutin formation|up-regulation of cutin synthesis|upregulation of cutin anabolism|upregulation of cutin biosynthesis|upregulation of cutin biosynthetic process|upregulation of cutin formation|upregulation of cutin synthesis http://purl.obolibrary.org/obo/GO_1901959 GO:1901956 biolink:BiologicalProcess positive regulation of retrograde dense core granule transport Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport. go.json activation of retrograde dense core granule transport|up regulation of retrograde dense core granule transport|up-regulation of retrograde dense core granule transport|upregulation of retrograde dense core granule transport http://purl.obolibrary.org/obo/GO_1901956 GO:1901957 biolink:BiologicalProcess regulation of cutin biosynthetic process Any process that modulates the frequency, rate or extent of cutin biosynthetic process. go.json regulation of cutin anabolism|regulation of cutin biosynthesis|regulation of cutin formation|regulation of cutin synthesis http://purl.obolibrary.org/obo/GO_1901957 GO:1901954 biolink:BiologicalProcess regulation of retrograde dense core granule transport Any process that modulates the frequency, rate or extent of retrograde dense core granule transport. go.json http://purl.obolibrary.org/obo/GO_1901954 GO:1901955 biolink:BiologicalProcess negative regulation of retrograde dense core granule transport Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport. go.json down regulation of retrograde dense core granule transport|down-regulation of retrograde dense core granule transport|downregulation of retrograde dense core granule transport|inhibition of retrograde dense core granule transport http://purl.obolibrary.org/obo/GO_1901955 GO:1901952 biolink:BiologicalProcess negative regulation of anterograde dense core granule transport Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport. go.json down regulation of anterograde dense core granule transport|down-regulation of anterograde dense core granule transport|downregulation of anterograde dense core granule transport|inhibition of anterograde dense core granule transport http://purl.obolibrary.org/obo/GO_1901952 GO:0045468 biolink:BiologicalProcess regulation of R8 cell spacing in compound eye Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc. go.json R8 cell spacing in compound eye|regulation of R8 spacing http://purl.obolibrary.org/obo/GO_0045468 GO:0045469 biolink:BiologicalProcess negative regulation of R8 cell spacing in compound eye Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye. go.json down regulation of R8 spacing|down-regulation of R8 spacing|downregulation of R8 spacing|inhibition of R8 spacing http://purl.obolibrary.org/obo/GO_0045469 GO:1901953 biolink:BiologicalProcess positive regulation of anterograde dense core granule transport Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport. go.json activation of anterograde dense core granule transport|up regulation of anterograde dense core granule transport|up-regulation of anterograde dense core granule transport|upregulation of anterograde dense core granule transport http://purl.obolibrary.org/obo/GO_1901953 GO:1901950 biolink:BiologicalProcess dense core granule transport The directed movement a dense core granule within a cell. go.json dense core vesicle transport http://purl.obolibrary.org/obo/GO_1901950 GO:0045466 biolink:BiologicalProcess R7 cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor. go.json http://purl.obolibrary.org/obo/GO_0045466 GO:1901951 biolink:BiologicalProcess regulation of anterograde dense core granule transport Any process that modulates the frequency, rate or extent of anterograde dense core granule transport. go.json http://purl.obolibrary.org/obo/GO_1901951 GO:0045467 biolink:BiologicalProcess R7 cell development The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium. go.json http://purl.obolibrary.org/obo/GO_0045467 GO:0045464 biolink:BiologicalProcess R8 cell fate specification The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0045464 GO:0045465 biolink:BiologicalProcess R8 cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor. go.json http://purl.obolibrary.org/obo/GO_0045465 GO:0045462 biolink:MolecularActivity trichothecene 3-O-acetyltransferase activity Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis. go.json http://purl.obolibrary.org/obo/GO_0045462 GO:0045463 biolink:BiologicalProcess R8 cell development The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium. go.json http://purl.obolibrary.org/obo/GO_0045463 GO:0070408 biolink:BiologicalProcess carbamoyl phosphate metabolic process The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. UM-BBD_pathwayID:bzn go.json carbamoyl phosphate metabolism http://purl.obolibrary.org/obo/GO_0070408 GO:0070409 biolink:BiologicalProcess carbamoyl phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. go.json carbamoyl phosphate anabolism|carbamoyl phosphate biosynthesis|carbamoyl phosphate formation|carbamoyl phosphate synthesis|carbamyl phosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0070409 GO:0070406 biolink:MolecularActivity glutamine binding Binding to glutamine, 2,5-diamino-5-oxopentanoic acid. go.json http://purl.obolibrary.org/obo/GO_0070406 GO:0070407 biolink:BiologicalProcess oxidation-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein. go.json oxidation-dependent protein breakdown|oxidation-dependent protein catabolism|oxidation-dependent protein degradation|oxidation-dependent proteolysis|oxidized protein catabolic process http://purl.obolibrary.org/obo/GO_0070407 GO:0070404 biolink:MolecularActivity NADH binding Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. go.json NAD (reduced) binding|reduced NAD binding|reduced nicotinamide adenine dinucleotide binding http://purl.obolibrary.org/obo/GO_0070404 GO:0070405 biolink:MolecularActivity ammonium ion binding Binding to ammonium ions (NH4+). go.json ammonium binding http://purl.obolibrary.org/obo/GO_0070405 GO:0070402 biolink:MolecularActivity NADPH binding Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. go.json NADP (reduced) binding|reduced NADP binding|reduced nicotinamide adenine dinucleotide phosphate binding http://purl.obolibrary.org/obo/GO_0070402 GO:0070403 biolink:MolecularActivity NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. go.json NAD (oxidized) binding|NAD binding|oxidized NAD binding|oxidized nicotinamide adenine dinucleotide binding http://purl.obolibrary.org/obo/GO_0070403 GO:0070400 biolink:BiologicalProcess teichoic acid D-alanylation The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid. go.json teichoic acid alanylation http://purl.obolibrary.org/obo/GO_0070400 GO:0070401 biolink:MolecularActivity NADP+ binding Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. go.json NADP (oxidized) binding|NADP binding|oxidized NADP binding|oxidized nicotinamide adenine dinucleotide phosphate binding http://purl.obolibrary.org/obo/GO_0070401 GO:0070394 biolink:BiologicalProcess lipoteichoic acid metabolic process The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. go.json LTA metabolic process|lipoteichoic acid metabolism http://purl.obolibrary.org/obo/GO_0070394 GO:0070395 biolink:BiologicalProcess lipoteichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. go.json LTA biosynthetic process|lipoteichoic acid anabolism|lipoteichoic acid biosynthesis|lipoteichoic acid formation|lipoteichoic acid synthesis http://purl.obolibrary.org/obo/GO_0070395 GO:0070392 biolink:BiologicalProcess detection of lipoteichoic acid The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. go.json detection of LTA http://purl.obolibrary.org/obo/GO_0070392 GO:0070393 biolink:BiologicalProcess teichoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues. go.json teichoic acid breakdown|teichoic acid catabolism|teichoic acid degradation http://purl.obolibrary.org/obo/GO_0070393 GO:0070390 biolink:CellularComponent transcription export complex 2 A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p. go.json Sac3-Thp1-Sus1-Sem1-Cdc31 complex|TREX-2 complex http://purl.obolibrary.org/obo/GO_0070390 GO:0070391 biolink:BiologicalProcess response to lipoteichoic acid Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. go.json response to LTA http://purl.obolibrary.org/obo/GO_0070391 GO:0070398 biolink:BiologicalProcess wall teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. go.json WTA biosynthetic process|wall teichoic acid anabolism|wall teichoic acid biosynthesis|wall teichoic acid formation|wall teichoic acid synthesis http://purl.obolibrary.org/obo/GO_0070398 GO:0070399 biolink:BiologicalProcess wall teichoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. go.json wall teichoic acid breakdown|wall teichoic acid catabolism|wall teichoic acid degradation http://purl.obolibrary.org/obo/GO_0070399 GO:0070396 biolink:BiologicalProcess lipoteichoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. go.json lipoteichoic acid breakdown|lipoteichoic acid catabolism|lipoteichoic acid degradation http://purl.obolibrary.org/obo/GO_0070396 GO:0070397 biolink:BiologicalProcess wall teichoic acid metabolic process The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. go.json WTA metabolic process|wall teichoic acid metabolism http://purl.obolibrary.org/obo/GO_0070397 GO:0070383 biolink:BiologicalProcess DNA cytosine deamination The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. go.json http://purl.obolibrary.org/obo/GO_0070383 GO:0070384 biolink:BiologicalProcess Harderian gland development The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species. go.json http://purl.obolibrary.org/obo/GO_0070384 GO:0070381 biolink:CellularComponent endosome to plasma membrane transport vesicle A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis. go.json endosome to plasma membrane constitutive secretory pathway transport vesicle|endosome-plasma membrane transport vesicle http://purl.obolibrary.org/obo/GO_0070381 GO:0070382 biolink:CellularComponent exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. go.json exocytic constitutive secretory pathway transport vesicle|exocytotic vesicle http://purl.obolibrary.org/obo/GO_0070382 GO:0070380 biolink:MolecularActivity high mobility group box 1 receptor activity Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json HMGB1 receptor activity http://purl.obolibrary.org/obo/GO_0070380 GO:0070389 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070389 GO:0070387 biolink:CellularComponent procollagen-proline 4-dioxygenase complex, alpha(II) type A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations. go.json procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type|prolyl 4-hydroxylase complex (alpha(II)-type) http://purl.obolibrary.org/obo/GO_0070387 GO:0070388 biolink:CellularComponent procollagen-proline 4-dioxygenase complex, alpha(III) type A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform. go.json procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type|prolyl 4-hydroxylase complex (alpha(III)-type) http://purl.obolibrary.org/obo/GO_0070388 GO:0070385 biolink:CellularComponent egasyn-beta-glucuronidase complex A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0070385 GO:0070386 biolink:CellularComponent procollagen-proline 4-dioxygenase complex, alpha(I) type A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline). go.json procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type|prolyl 4-hydroxylase complex (alpha(I)-type) http://purl.obolibrary.org/obo/GO_0070386 GO:0045350 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045350 GO:0045351 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045351 GO:1901848 biolink:BiologicalProcess nicotinate catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinate. go.json nicotinate breakdown|nicotinate catabolism|nicotinate degradation http://purl.obolibrary.org/obo/GO_1901848 GO:1901849 biolink:BiologicalProcess nicotinate biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinate. go.json nicotinate anabolism|nicotinate biosynthesis|nicotinate formation|nicotinate synthesis http://purl.obolibrary.org/obo/GO_1901849 GO:1901846 biolink:BiologicalProcess positive regulation of cell communication by electrical coupling involved in cardiac conduction Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. go.json activation of cell communication by electrical coupling involved in cardiac conduction|up regulation of cell communication by electrical coupling involved in cardiac conduction|up-regulation of cell communication by electrical coupling involved in cardiac conduction|upregulation of cell communication by electrical coupling involved in cardiac conduction http://purl.obolibrary.org/obo/GO_1901846 GO:1901847 biolink:BiologicalProcess nicotinate metabolic process The chemical reactions and pathways involving nicotinate. go.json nicotinate metabolism http://purl.obolibrary.org/obo/GO_1901847 GO:1901844 biolink:BiologicalProcess regulation of cell communication by electrical coupling involved in cardiac conduction Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. go.json http://purl.obolibrary.org/obo/GO_1901844 GO:1901845 biolink:BiologicalProcess negative regulation of cell communication by electrical coupling involved in cardiac conduction Any process that stops, prevents or reduces the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. go.json down regulation of cell communication by electrical coupling involved in cardiac conduction|down-regulation of cell communication by electrical coupling involved in cardiac conduction|downregulation of cell communication by electrical coupling involved in cardiac conduction|inhibition of cell communication by electrical coupling involved in cardiac conduction http://purl.obolibrary.org/obo/GO_1901845 GO:0045358 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045358 GO:1901842 biolink:BiologicalProcess negative regulation of high voltage-gated calcium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity. go.json down regulation of high voltage gated calcium channel activity|down regulation of high voltage-dependent calcium channel activity|down regulation of high voltage-gated calcium channel activity|down-regulation of high voltage gated calcium channel activity|down-regulation of high voltage-dependent calcium channel activity|down-regulation of high voltage-gated calcium channel activity|downregulation of high voltage gated calcium channel activity|downregulation of high voltage-dependent calcium channel activity|downregulation of high voltage-gated calcium channel activity|inhibition of high voltage gated calcium channel activity|inhibition of high voltage-dependent calcium channel activity|inhibition of high voltage-gated calcium channel activity|negative regulation of high voltage gated calcium channel activity|negative regulation of high voltage-dependent calcium channel activity http://purl.obolibrary.org/obo/GO_1901842 gocheck_do_not_annotate GO:1901843 biolink:BiologicalProcess positive regulation of high voltage-gated calcium channel activity Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity. go.json activation of high voltage gated calcium channel activity|activation of high voltage-dependent calcium channel activity|activation of high voltage-gated calcium channel activity|positive regulation of high voltage gated calcium channel activity|positive regulation of high voltage-dependent calcium channel activity|up regulation of high voltage gated calcium channel activity|up regulation of high voltage-dependent calcium channel activity|up regulation of high voltage-gated calcium channel activity|up-regulation of high voltage gated calcium channel activity|up-regulation of high voltage-dependent calcium channel activity|up-regulation of high voltage-gated calcium channel activity|upregulation of high voltage gated calcium channel activity|upregulation of high voltage-dependent calcium channel activity|upregulation of high voltage-gated calcium channel activity http://purl.obolibrary.org/obo/GO_1901843 gocheck_do_not_annotate GO:0045359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045359 GO:0045356 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045356 GO:1901840 biolink:BiologicalProcess negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding. go.json down regulation of RNA polymerase I regulatory region sequence-specific DNA binding|down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding|downregulation of RNA polymerase I regulatory region sequence-specific DNA binding|inhibition of RNA polymerase I regulatory region sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_1901840 gocheck_do_not_annotate GO:1901841 biolink:BiologicalProcess regulation of high voltage-gated calcium channel activity Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity. go.json regulation of high voltage gated calcium channel activity|regulation of high voltage-dependent calcium channel activity http://purl.obolibrary.org/obo/GO_1901841 gocheck_do_not_annotate GO:0045357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045357 GO:0045354 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045354 GO:0045355 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045355 GO:0045352 biolink:MolecularActivity interleukin-1 type I receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 type I receptors. go.json IL-1ra type I http://purl.obolibrary.org/obo/GO_0045352 GO:0060990 biolink:BiologicalProcess lipid tube assembly involved in organelle fission The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission. go.json lipid tubulation involved in organelle fission http://purl.obolibrary.org/obo/GO_0060990 GO:0045353 biolink:MolecularActivity interleukin-1 type II receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 type II receptors. go.json IL-1ra type II http://purl.obolibrary.org/obo/GO_0045353 GO:0060991 biolink:BiologicalProcess obsolete lipid tube assembly involved in cytokinesis OBSOLETE. The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis. go.json lipid tube assembly involved in cytokinesis|lipid tubulation involved in cytokinesis True http://purl.obolibrary.org/obo/GO_0060991 GO:0060992 biolink:BiologicalProcess response to fungicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. go.json http://purl.obolibrary.org/obo/GO_0060992 GO:0060993 biolink:BiologicalProcess kidney morphogenesis Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0060993 GO:0060994 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in kidney development OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state. go.json True http://purl.obolibrary.org/obo/GO_0060994 GO:0060995 biolink:BiologicalProcess cell-cell signaling involved in kidney development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ. go.json cell-cell signalling involved in kidney development http://purl.obolibrary.org/obo/GO_0060995 GO:0070318 biolink:BiologicalProcess positive regulation of G0 to G1 transition A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase. go.json http://purl.obolibrary.org/obo/GO_0070318 GO:0070319 biolink:CellularComponent Golgi to plasma membrane transport vesicle A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. go.json Golgi to plasma membrane constitutive secretory pathway transport vesicle|Golgi-plasma membrane transport vesicle http://purl.obolibrary.org/obo/GO_0070319 GO:0060996 biolink:BiologicalProcess dendritic spine development The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0060996 GO:0070316 biolink:BiologicalProcess regulation of G0 to G1 transition A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase. go.json http://purl.obolibrary.org/obo/GO_0070316 GO:0060997 biolink:BiologicalProcess dendritic spine morphogenesis The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0060997 GO:0070317 biolink:BiologicalProcess negative regulation of G0 to G1 transition A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase. go.json maintenance of G0 arrest|maintenance of G0 phase|maintenance of cell cycle quiescence|maintenance of cell quiescence http://purl.obolibrary.org/obo/GO_0070317 GO:0060998 biolink:BiologicalProcess regulation of dendritic spine development Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060998 GO:0070314 biolink:BiologicalProcess G1 to G0 transition A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence. go.json G1/G0 transition|cell cycle quiescence|establishment of cell quiescence|stationary phase http://purl.obolibrary.org/obo/GO_0070314 GO:0060999 biolink:BiologicalProcess positive regulation of dendritic spine development Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060999 GO:0070315 biolink:BiologicalProcess G1 to G0 transition involved in cell differentiation A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation. go.json G1/G0 transition involved in cell differentiation http://purl.obolibrary.org/obo/GO_0070315 GO:0070312 biolink:CellularComponent RAD52-ERCC4-ERCC1 complex A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein. go.json http://purl.obolibrary.org/obo/GO_0070312 GO:0070313 biolink:CellularComponent RGS6-DNMT1-DMAP1 complex A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1. go.json http://purl.obolibrary.org/obo/GO_0070313 GO:0070310 biolink:CellularComponent ATR-ATRIP complex A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A. go.json Mec1-Lcd1 complex|Rad3-Rad26 complex http://purl.obolibrary.org/obo/GO_0070310 GO:0070311 biolink:CellularComponent nucleosomal methylation activator complex A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription. go.json NUMAC http://purl.obolibrary.org/obo/GO_0070311 GO:0045361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045361 GO:0045362 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045362 GO:1901859 biolink:BiologicalProcess negative regulation of mitochondrial DNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process. go.json down regulation of mitochondrial DNA metabolic process|down regulation of mitochondrial DNA metabolism|down regulation of mtDNA metabolic process|down regulation of mtDNA metabolism|down-regulation of mitochondrial DNA metabolic process|down-regulation of mitochondrial DNA metabolism|down-regulation of mtDNA metabolic process|down-regulation of mtDNA metabolism|downregulation of mitochondrial DNA metabolic process|downregulation of mitochondrial DNA metabolism|downregulation of mtDNA metabolic process|downregulation of mtDNA metabolism|inhibition of mitochondrial DNA metabolic process|inhibition of mitochondrial DNA metabolism|inhibition of mtDNA metabolic process|inhibition of mtDNA metabolism|negative regulation of mitochondrial DNA metabolism|negative regulation of mtDNA metabolic process|negative regulation of mtDNA metabolism http://purl.obolibrary.org/obo/GO_1901859 GO:0045360 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045360 GO:1901857 biolink:BiologicalProcess positive regulation of cellular respiration Any process that activates or increases the frequency, rate or extent of cellular respiration. go.json activation of cellular respiration|activation of oxidative metabolic process|activation of oxidative metabolism|activation of respiration|positive regulation of oxidative metabolic process|positive regulation of oxidative metabolism|positive regulation of respiration|up regulation of cellular respiration|up regulation of oxidative metabolic process|up regulation of oxidative metabolism|up regulation of respiration|up-regulation of cellular respiration|up-regulation of oxidative metabolic process|up-regulation of oxidative metabolism|up-regulation of respiration|upregulation of cellular respiration|upregulation of oxidative metabolic process|upregulation of oxidative metabolism|upregulation of respiration http://purl.obolibrary.org/obo/GO_1901857 GO:1901858 biolink:BiologicalProcess regulation of mitochondrial DNA metabolic process Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process. go.json regulation of mitochondrial DNA metabolism|regulation of mtDNA metabolic process|regulation of mtDNA metabolism http://purl.obolibrary.org/obo/GO_1901858 GO:1901855 biolink:BiologicalProcess 5,6,7,8-tetrahydrosarcinapterin biosynthetic process The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydrosarcinapterin. go.json 5,6,7,8-tetrahydrosarcinapterin anabolism|5,6,7,8-tetrahydrosarcinapterin biosynthesis|5,6,7,8-tetrahydrosarcinapterin formation|5,6,7,8-tetrahydrosarcinapterin synthesis http://purl.obolibrary.org/obo/GO_1901855 GO:1901856 biolink:BiologicalProcess negative regulation of cellular respiration Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration. go.json down regulation of cellular respiration|down regulation of oxidative metabolic process|down regulation of oxidative metabolism|down regulation of respiration|down-regulation of cellular respiration|down-regulation of oxidative metabolic process|down-regulation of oxidative metabolism|down-regulation of respiration|downregulation of cellular respiration|downregulation of oxidative metabolic process|downregulation of oxidative metabolism|downregulation of respiration|inhibition of cellular respiration|inhibition of oxidative metabolic process|inhibition of oxidative metabolism|inhibition of respiration|negative regulation of oxidative metabolic process|negative regulation of oxidative metabolism|negative regulation of respiration http://purl.obolibrary.org/obo/GO_1901856 GO:1901853 biolink:BiologicalProcess 5,6,7,8-tetrahydrosarcinapterin metabolic process The chemical reactions and pathways involving 5,6,7,8-tetrahydrosarcinapterin. go.json 5,6,7,8-tetrahydrosarcinapterin metabolism http://purl.obolibrary.org/obo/GO_1901853 GO:0045369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045369 GO:1901854 biolink:BiologicalProcess 5,6,7,8-tetrahydrosarcinapterin catabolic process The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin. go.json 5,6,7,8-tetrahydrosarcinapterin breakdown|5,6,7,8-tetrahydrosarcinapterin catabolism|5,6,7,8-tetrahydrosarcinapterin degradation http://purl.obolibrary.org/obo/GO_1901854 GO:1901851 biolink:BiologicalProcess 7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process The chemical reactions and pathways resulting in the breakdown of 7,8-didemethyl-8-hydroxy-5-deazariboflavin. go.json 7,8-didemethyl-8-hydroxy-5-deazariboflavin breakdown|7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolism|7,8-didemethyl-8-hydroxy-5-deazariboflavin degradation|coenzyme F0 breakdown|coenzyme F0 catabolic process|coenzyme F0 catabolism|coenzyme F0 degradation http://purl.obolibrary.org/obo/GO_1901851 GO:0045367 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045367 GO:0045368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045368 GO:1901852 biolink:BiologicalProcess 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin. go.json 7,8-didemethyl-8-hydroxy-5-deazariboflavin anabolism|7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis|7,8-didemethyl-8-hydroxy-5-deazariboflavin formation|7,8-didemethyl-8-hydroxy-5-deazariboflavin synthesis|coenzyme F0 anabolism|coenzyme F0 biosynthesis|coenzyme F0 biosynthetic process|coenzyme F0 formation|coenzyme F0 synthesis http://purl.obolibrary.org/obo/GO_1901852 GO:0045365 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045365 GO:1901850 biolink:BiologicalProcess 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-deazariboflavin. go.json 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism|coenzyme F0 metabolism http://purl.obolibrary.org/obo/GO_1901850 GO:0045366 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045366 GO:0045363 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045363 GO:0045364 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045364 GO:0060980 biolink:BiologicalProcess cell migration involved in coronary vasculogenesis The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. go.json http://purl.obolibrary.org/obo/GO_0060980 GO:0060981 biolink:BiologicalProcess cell migration involved in coronary angiogenesis The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. go.json http://purl.obolibrary.org/obo/GO_0060981 GO:0070309 biolink:BiologicalProcess lens fiber cell morphogenesis The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. go.json elongation of lens fiber cell|lens fiber cell morphogenesis during differentiation|lens fibre cell morphogenesis http://purl.obolibrary.org/obo/GO_0070309 GO:0060982 biolink:BiologicalProcess coronary artery morphogenesis The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle. go.json http://purl.obolibrary.org/obo/GO_0060982 GO:0060983 biolink:BiologicalProcess epicardium-derived cardiac vascular smooth muscle cell differentiation The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. go.json http://purl.obolibrary.org/obo/GO_0060983 GO:0060984 biolink:BiologicalProcess epicardium-derived cardiac vascular smooth muscle cell development The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0060984 GO:0070307 biolink:BiologicalProcess lens fiber cell development The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. go.json lens fibre cell development http://purl.obolibrary.org/obo/GO_0070307 GO:0070308 biolink:BiologicalProcess lens fiber cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. go.json lens fibre cell fate commitment http://purl.obolibrary.org/obo/GO_0070308 GO:0060985 biolink:BiologicalProcess epicardium-derived cardiac vascular smooth muscle cell fate commitment The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell. go.json http://purl.obolibrary.org/obo/GO_0060985 GO:0060986 biolink:BiologicalProcess endocrine hormone secretion The regulated release of a hormone into the circulatory system. go.json http://purl.obolibrary.org/obo/GO_0060986 GO:0070305 biolink:BiologicalProcess response to cGMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. go.json response to 3',5' cGMP|response to 3',5'-cGMP|response to cyclic GMP|response to guanosine 3',5'-cyclophosphate http://purl.obolibrary.org/obo/GO_0070305 GO:0070306 biolink:BiologicalProcess lens fiber cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. go.json lens fibre cell differentiation http://purl.obolibrary.org/obo/GO_0070306 GO:0060987 biolink:CellularComponent lipid tube A macromolecular complex that contains a tube of lipid surrounded by a protein coat. go.json http://purl.obolibrary.org/obo/GO_0060987 GO:0070303 biolink:BiologicalProcess negative regulation of stress-activated protein kinase signaling cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. go.json down regulation of stress-activated protein kinase signaling pathway|down-regulation of stress-activated protein kinase signaling pathway|downregulation of stress-activated protein kinase signaling pathway|inhibition of stress-activated protein kinase signaling pathway|negative regulation of SAPK signaling pathway|negative regulation of stress-activated protein kinase signaling pathway|negative regulation of stress-activated protein kinase signalling pathway http://purl.obolibrary.org/obo/GO_0070303 GO:0060988 biolink:BiologicalProcess lipid tube assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission. go.json lipid tubulation http://purl.obolibrary.org/obo/GO_0060988 GO:0060989 biolink:BiologicalProcess lipid tube assembly involved in organelle fusion The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse. go.json lipid tubulation involved in organelle fusion http://purl.obolibrary.org/obo/GO_0060989 GO:0070304 biolink:BiologicalProcess positive regulation of stress-activated protein kinase signaling cascade Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. go.json activation of stress-activated protein kinase signaling pathway|positive regulation of SAPK signaling pathway|positive regulation of stress-activated protein kinase signaling pathway|positive regulation of stress-activated protein kinase signalling pathway|stimulation of stress-activated protein kinase signaling pathway|up regulation of stress-activated protein kinase signaling pathway|up-regulation of stress-activated protein kinase signaling pathway|upregulation of stress-activated protein kinase signaling pathway http://purl.obolibrary.org/obo/GO_0070304 GO:0070301 biolink:BiologicalProcess cellular response to hydrogen peroxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0070301 GO:0070302 biolink:BiologicalProcess regulation of stress-activated protein kinase signaling cascade Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. go.json regulation of SAPK signaling pathway|regulation of stress-activated protein kinase signaling pathway|regulation of stress-activated protein kinase signalling pathway http://purl.obolibrary.org/obo/GO_0070302 GO:0070300 biolink:MolecularActivity phosphatidic acid binding Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. go.json phosphatidate binding http://purl.obolibrary.org/obo/GO_0070300 GO:0045372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045372 GO:0045373 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045373 GO:0045370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045370 GO:0045371 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045371 GO:1901868 biolink:BiologicalProcess ecgonine methyl ester catabolic process The chemical reactions and pathways resulting in the breakdown of ecgonine methyl ester. go.json ecgonine methyl ester breakdown|ecgonine methyl ester catabolism|ecgonine methyl ester degradation http://purl.obolibrary.org/obo/GO_1901868 GO:1901869 biolink:BiologicalProcess ecgonine methyl ester biosynthetic process The chemical reactions and pathways resulting in the formation of ecgonine methyl ester. go.json ecgonine methyl ester anabolism|ecgonine methyl ester biosynthesis|ecgonine methyl ester formation|ecgonine methyl ester synthesis http://purl.obolibrary.org/obo/GO_1901869 GO:1901866 biolink:BiologicalProcess capsorubin biosynthetic process The chemical reactions and pathways resulting in the formation of capsorubin. go.json capsorubin anabolism|capsorubin biosynthesis|capsorubin formation|capsorubin synthesis http://purl.obolibrary.org/obo/GO_1901866 GO:1901867 biolink:BiologicalProcess ecgonine methyl ester metabolic process The chemical reactions and pathways involving ecgonine methyl ester. go.json ecgonine methyl ester metabolism http://purl.obolibrary.org/obo/GO_1901867 GO:1901864 biolink:BiologicalProcess capsorubin metabolic process The chemical reactions and pathways involving capsorubin. go.json capsorubin metabolism http://purl.obolibrary.org/obo/GO_1901864 GO:1901865 biolink:BiologicalProcess capsorubin catabolic process The chemical reactions and pathways resulting in the breakdown of capsorubin. go.json capsorubin breakdown|capsorubin catabolism|capsorubin degradation http://purl.obolibrary.org/obo/GO_1901865 GO:1901862 biolink:BiologicalProcess negative regulation of muscle tissue development Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. go.json down regulation of muscle tissue development|down-regulation of muscle tissue development|downregulation of muscle tissue development|inhibition of muscle tissue development http://purl.obolibrary.org/obo/GO_1901862 GO:0045378 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045378 GO:1901863 biolink:BiologicalProcess positive regulation of muscle tissue development Any process that activates or increases the frequency, rate or extent of muscle tissue development. go.json activation of muscle tissue development|up regulation of muscle tissue development|up-regulation of muscle tissue development|upregulation of muscle tissue development http://purl.obolibrary.org/obo/GO_1901863 GO:0045379 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045379 GO:1901860 biolink:BiologicalProcess positive regulation of mitochondrial DNA metabolic process Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process. go.json activation of mitochondrial DNA metabolic process|activation of mitochondrial DNA metabolism|activation of mtDNA metabolic process|activation of mtDNA metabolism|positive regulation of mitochondrial DNA metabolism|positive regulation of mtDNA metabolic process|positive regulation of mtDNA metabolism|up regulation of mitochondrial DNA metabolic process|up regulation of mitochondrial DNA metabolism|up regulation of mtDNA metabolic process|up regulation of mtDNA metabolism|up-regulation of mitochondrial DNA metabolic process|up-regulation of mitochondrial DNA metabolism|up-regulation of mtDNA metabolic process|up-regulation of mtDNA metabolism|upregulation of mitochondrial DNA metabolic process|upregulation of mitochondrial DNA metabolism|upregulation of mtDNA metabolic process|upregulation of mtDNA metabolism http://purl.obolibrary.org/obo/GO_1901860 GO:0045376 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045376 GO:0045377 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045377 GO:1901861 biolink:BiologicalProcess regulation of muscle tissue development Any process that modulates the frequency, rate or extent of muscle tissue development. go.json http://purl.obolibrary.org/obo/GO_1901861 GO:0045374 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045374 GO:0045375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045375 GO:0070338 biolink:MolecularActivity 5'-flap-structured DNA binding Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers. go.json http://purl.obolibrary.org/obo/GO_0070338 GO:0070339 biolink:BiologicalProcess response to bacterial lipopeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus. go.json http://purl.obolibrary.org/obo/GO_0070339 GO:0070336 biolink:MolecularActivity flap-structured DNA binding Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070336 GO:0070337 biolink:MolecularActivity 3'-flap-structured DNA binding Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070337 GO:0070334 biolink:CellularComponent alpha6-beta4 integrin-laminin 5 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5. go.json ITGA6-ITGB4-LAMA5 complex|alpha6-beta4 integrin-laminin-332 complex http://purl.obolibrary.org/obo/GO_0070334 GO:0070335 biolink:MolecularActivity aspartate binding Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4. go.json aspartic acid binding http://purl.obolibrary.org/obo/GO_0070335 GO:0070332 biolink:CellularComponent CD20-Lck-Lyn-Fyn complex A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn. go.json http://purl.obolibrary.org/obo/GO_0070332 GO:0070333 biolink:CellularComponent alpha6-beta4 integrin-Shc-Grb2 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2. go.json ITGA6-ITGB4-SHC-GRB2 complex http://purl.obolibrary.org/obo/GO_0070333 GO:0070330 biolink:MolecularActivity aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. EC:1.14.14.1|MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN|RHEA:17149|UM-BBD_enzymeID:e0551 go.json estrogen synthetase activity http://purl.obolibrary.org/obo/GO_0070330 GO:0070331 biolink:CellularComponent CD20-Lck-Fyn complex A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn. go.json http://purl.obolibrary.org/obo/GO_0070331 GO:0045383 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045383 GO:0045384 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045384 GO:0045381 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045381 GO:0045382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045382 GO:1901879 biolink:BiologicalProcess regulation of protein depolymerization Any process that modulates the frequency, rate or extent of protein depolymerization. go.json regulation of protein polymer breakdown|regulation of protein polymer catabolic process|regulation of protein polymer catabolism|regulation of protein polymer degradation http://purl.obolibrary.org/obo/GO_1901879 GO:0045380 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045380 GO:1901877 biolink:BiologicalProcess negative regulation of calcium ion binding Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding. go.json down regulation of calcium ion binding|down regulation of calcium ion storage activity|down-regulation of calcium ion binding|down-regulation of calcium ion storage activity|downregulation of calcium ion binding|downregulation of calcium ion storage activity|inhibition of calcium ion binding|inhibition of calcium ion storage activity|negative regulation of calcium ion storage activity http://purl.obolibrary.org/obo/GO_1901877 gocheck_do_not_annotate GO:1901878 biolink:BiologicalProcess positive regulation of calcium ion binding Any process that activates or increases the frequency, rate or extent of calcium ion binding. go.json activation of calcium ion binding|activation of calcium ion storage activity|positive regulation of calcium ion storage activity|up regulation of calcium ion binding|up regulation of calcium ion storage activity|up-regulation of calcium ion binding|up-regulation of calcium ion storage activity|upregulation of calcium ion binding|upregulation of calcium ion storage activity http://purl.obolibrary.org/obo/GO_1901878 gocheck_do_not_annotate GO:1901875 biolink:BiologicalProcess positive regulation of post-translational protein modification Any process that activates or increases the frequency, rate or extent of post-translational protein modification. go.json activation of PTM|activation of post-translational amino acid modification|activation of post-translational modification|activation of post-translational protein modification|activation of posttranslational amino acid modification|activation of posttranslational modification|activation of posttranslational protein modification|positive regulation of PTM|positive regulation of post-translational amino acid modification|positive regulation of post-translational modification|positive regulation of posttranslational amino acid modification|positive regulation of posttranslational modification|positive regulation of posttranslational protein modification|up regulation of PTM|up regulation of post-translational amino acid modification|up regulation of post-translational modification|up regulation of post-translational protein modification|up regulation of posttranslational amino acid modification|up regulation of posttranslational modification|up regulation of posttranslational protein modification|up-regulation of PTM|up-regulation of post-translational amino acid modification|up-regulation of post-translational modification|up-regulation of post-translational protein modification|up-regulation of posttranslational amino acid modification|up-regulation of posttranslational modification|up-regulation of posttranslational protein modification|upregulation of PTM|upregulation of post-translational amino acid modification|upregulation of post-translational modification|upregulation of post-translational protein modification|upregulation of posttranslational amino acid modification|upregulation of posttranslational modification|upregulation of posttranslational protein modification http://purl.obolibrary.org/obo/GO_1901875 GO:1901876 biolink:BiologicalProcess regulation of calcium ion binding Any process that modulates the frequency, rate or extent of calcium ion binding. go.json regulation of calcium ion storage activity http://purl.obolibrary.org/obo/GO_1901876 gocheck_do_not_annotate GO:1901873 biolink:BiologicalProcess regulation of post-translational protein modification Any process that modulates the frequency, rate or extent of post-translational protein modification. go.json regulation of PTM|regulation of post-translational amino acid modification|regulation of post-translational modification|regulation of posttranslational amino acid modification|regulation of posttranslational modification|regulation of posttranslational protein modification http://purl.obolibrary.org/obo/GO_1901873 GO:0045389 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045389 GO:1901874 biolink:BiologicalProcess negative regulation of post-translational protein modification Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification. go.json down regulation of PTM|down regulation of post-translational amino acid modification|down regulation of post-translational modification|down regulation of post-translational protein modification|down regulation of posttranslational amino acid modification|down regulation of posttranslational modification|down regulation of posttranslational protein modification|down-regulation of PTM|down-regulation of post-translational amino acid modification|down-regulation of post-translational modification|down-regulation of post-translational protein modification|down-regulation of posttranslational amino acid modification|down-regulation of posttranslational modification|down-regulation of posttranslational protein modification|downregulation of PTM|downregulation of post-translational amino acid modification|downregulation of post-translational modification|downregulation of post-translational protein modification|downregulation of posttranslational amino acid modification|downregulation of posttranslational modification|downregulation of posttranslational protein modification|inhibition of PTM|inhibition of post-translational amino acid modification|inhibition of post-translational modification|inhibition of post-translational protein modification|inhibition of posttranslational amino acid modification|inhibition of posttranslational modification|inhibition of posttranslational protein modification|negative regulation of PTM|negative regulation of post-translational amino acid modification|negative regulation of post-translational modification|negative regulation of posttranslational amino acid modification|negative regulation of posttranslational modification|negative regulation of posttranslational protein modification http://purl.obolibrary.org/obo/GO_1901874 GO:1901871 biolink:BiologicalProcess ecgonone methyl ester catabolic process The chemical reactions and pathways resulting in the breakdown of ecgonone methyl ester. go.json ecgonone methyl ester breakdown|ecgonone methyl ester catabolism|ecgonone methyl ester degradation http://purl.obolibrary.org/obo/GO_1901871 GO:0045387 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045387 GO:1901872 biolink:BiologicalProcess ecgonone methyl ester biosynthetic process The chemical reactions and pathways resulting in the formation of ecgonone methyl ester. go.json ecgonone methyl ester anabolism|ecgonone methyl ester biosynthesis|ecgonone methyl ester formation|ecgonone methyl ester synthesis http://purl.obolibrary.org/obo/GO_1901872 GO:0045388 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045388 GO:0045385 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045385 GO:1901870 biolink:BiologicalProcess ecgonone methyl ester metabolic process The chemical reactions and pathways involving ecgonone methyl ester. go.json ecgonone methyl ester metabolism http://purl.obolibrary.org/obo/GO_1901870 GO:0045386 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045386 GO:0070329 biolink:BiologicalProcess tRNA seleno-modification The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule. go.json tRNA base modification to selenouridine http://purl.obolibrary.org/obo/GO_0070329 GO:0070327 biolink:BiologicalProcess thyroid hormone transport The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json thyroxine transport|triiodothyronine transport http://purl.obolibrary.org/obo/GO_0070327 GO:0070328 biolink:BiologicalProcess triglyceride homeostasis Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. go.json triacylglycerol homeostasis http://purl.obolibrary.org/obo/GO_0070328 GO:0070325 biolink:MolecularActivity lipoprotein particle receptor binding Binding to a lipoprotein particle receptor. go.json http://purl.obolibrary.org/obo/GO_0070325 GO:0070326 biolink:MolecularActivity very-low-density lipoprotein particle receptor binding Binding to a very-low-density lipoprotein receptor. go.json VLDL receptor binding|VLDLR binding|apolipoprotein E receptor binding|very-low-density lipoprotein receptor binding http://purl.obolibrary.org/obo/GO_0070326 GO:0070323 biolink:BiologicalProcess obsolete positive regulation of translation in response to nitrogen starvation OBSOLETE. Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen. go.json activation of translation in response to nitrogen starvation|stimulation of translation in response to nitrogen starvation|up regulation of translation in response to nitrogen starvation|up-regulation of translation in response to nitrogen starvation|upregulation of translation in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_0070323 GO:0070324 biolink:MolecularActivity thyroid hormone binding Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. go.json thyroxine binding|triiodothyronine binding http://purl.obolibrary.org/obo/GO_0070324 goslim_chembl GO:0070321 biolink:BiologicalProcess obsolete regulation of translation in response to nitrogen starvation OBSOLETE. Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen. go.json True http://purl.obolibrary.org/obo/GO_0070321 GO:0070322 biolink:BiologicalProcess obsolete negative regulation of translation in response to nitrogen starvation OBSOLETE. Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen. go.json down regulation of translation in response to nitrogen starvation|down-regulation of translation in response to nitrogen starvation|downregulation of translation in response to nitrogen starvation|inhibition of translation in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_0070322 GO:0070320 biolink:MolecularActivity inward rectifier potassium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel. go.json http://purl.obolibrary.org/obo/GO_0070320 GO:0070350 biolink:BiologicalProcess regulation of white fat cell proliferation Any process that modulates the frequency, rate or extent of white fat cell proliferation. go.json regulation of white adipocyte proliferation|regulation of white adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070350 GO:0045394 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045394 GO:0045395 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045395 GO:0070351 biolink:BiologicalProcess negative regulation of white fat cell proliferation Any process that stops or decreases the rate or extent of white fat cell proliferation. go.json down regulation of white fat cell proliferation|down-regulation of white fat cell proliferation|downregulation of white fat cell proliferation|inhibition of white fat cell proliferation|negative regulation of white adipocyte proliferation|negative regulation of white adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070351 GO:0045392 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045392 GO:0045393 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045393 GO:0045390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045390 GO:0045391 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045391 GO:1901888 biolink:BiologicalProcess regulation of cell junction assembly Any process that modulates the frequency, rate or extent of cell junction assembly. go.json http://purl.obolibrary.org/obo/GO_1901888 GO:1901889 biolink:BiologicalProcess negative regulation of cell junction assembly Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. go.json down regulation of cell junction assembly|down-regulation of cell junction assembly|downregulation of cell junction assembly|inhibition of cell junction assembly http://purl.obolibrary.org/obo/GO_1901889 GO:1901886 biolink:BiologicalProcess 2-hydroxybenzoyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA. go.json 2-hydroxybenzoyl-CoA breakdown|2-hydroxybenzoyl-CoA catabolism|2-hydroxybenzoyl-CoA degradation http://purl.obolibrary.org/obo/GO_1901886 GO:1901887 biolink:BiologicalProcess 2-hydroxybenzoyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of 2-hydroxybenzoyl-CoA. go.json 2-hydroxybenzoyl-CoA anabolism|2-hydroxybenzoyl-CoA biosynthesis|2-hydroxybenzoyl-CoA formation|2-hydroxybenzoyl-CoA synthesis http://purl.obolibrary.org/obo/GO_1901887 GO:1901884 biolink:BiologicalProcess 4-hydroxycoumarin biosynthetic process The chemical reactions and pathways resulting in the formation of 4-hydroxycoumarin. go.json 4-hydroxycoumarin anabolism|4-hydroxycoumarin biosynthesis|4-hydroxycoumarin formation|4-hydroxycoumarin synthesis http://purl.obolibrary.org/obo/GO_1901884 GO:1901885 biolink:BiologicalProcess 2-hydroxybenzoyl-CoA metabolic process The chemical reactions and pathways involving 2-hydroxybenzoyl-CoA. go.json 2-hydroxybenzoyl-CoA metabolism http://purl.obolibrary.org/obo/GO_1901885 GO:1901882 biolink:BiologicalProcess 4-hydroxycoumarin metabolic process The chemical reactions and pathways involving 4-hydroxycoumarin. go.json 4-hydroxycoumarin metabolism http://purl.obolibrary.org/obo/GO_1901882 GO:0045398 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045398 GO:1901883 biolink:BiologicalProcess 4-hydroxycoumarin catabolic process The chemical reactions and pathways resulting in the breakdown of 4-hydroxycoumarin. go.json 4-hydroxycoumarin breakdown|4-hydroxycoumarin catabolism|4-hydroxycoumarin degradation http://purl.obolibrary.org/obo/GO_1901883 GO:0045399 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045399 GO:1901880 biolink:BiologicalProcess negative regulation of protein depolymerization Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. go.json down regulation of protein depolymerization|down regulation of protein polymer breakdown|down regulation of protein polymer catabolic process|down regulation of protein polymer catabolism|down regulation of protein polymer degradation|down-regulation of protein depolymerization|down-regulation of protein polymer breakdown|down-regulation of protein polymer catabolic process|down-regulation of protein polymer catabolism|down-regulation of protein polymer degradation|downregulation of protein depolymerization|downregulation of protein polymer breakdown|downregulation of protein polymer catabolic process|downregulation of protein polymer catabolism|downregulation of protein polymer degradation|inhibition of protein depolymerization|inhibition of protein polymer breakdown|inhibition of protein polymer catabolic process|inhibition of protein polymer catabolism|inhibition of protein polymer degradation|negative regulation of protein polymer breakdown|negative regulation of protein polymer catabolic process|negative regulation of protein polymer catabolism|negative regulation of protein polymer degradation http://purl.obolibrary.org/obo/GO_1901880 GO:0045396 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045396 GO:1901881 biolink:BiologicalProcess positive regulation of protein depolymerization Any process that activates or increases the frequency, rate or extent of protein depolymerization. go.json activation of protein depolymerization|activation of protein polymer breakdown|activation of protein polymer catabolic process|activation of protein polymer catabolism|activation of protein polymer degradation|positive regulation of protein polymer breakdown|positive regulation of protein polymer catabolic process|positive regulation of protein polymer catabolism|positive regulation of protein polymer degradation|up regulation of protein depolymerization|up regulation of protein polymer breakdown|up regulation of protein polymer catabolic process|up regulation of protein polymer catabolism|up regulation of protein polymer degradation|up-regulation of protein depolymerization|up-regulation of protein polymer breakdown|up-regulation of protein polymer catabolic process|up-regulation of protein polymer catabolism|up-regulation of protein polymer degradation|upregulation of protein depolymerization|upregulation of protein polymer breakdown|upregulation of protein polymer catabolic process|upregulation of protein polymer catabolism|upregulation of protein polymer degradation http://purl.obolibrary.org/obo/GO_1901881 GO:0045397 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045397 GO:1901890 biolink:BiologicalProcess positive regulation of cell junction assembly Any process that activates or increases the frequency, rate or extent of cell junction assembly. go.json activation of cell junction assembly|up regulation of cell junction assembly|up-regulation of cell junction assembly|upregulation of cell junction assembly http://purl.obolibrary.org/obo/GO_1901890 GO:0070358 biolink:BiologicalProcess actin polymerization-dependent cell motility A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell. go.json cell motility by actin tail formation http://purl.obolibrary.org/obo/GO_0070358 GO:0070359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070359 GO:0070356 biolink:CellularComponent synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof). go.json SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)|STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex http://purl.obolibrary.org/obo/GO_0070356 GO:0070357 biolink:CellularComponent alphav-beta3 integrin-CD47 complex A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP). go.json ITGB3-ITGAV-CD47 complex http://purl.obolibrary.org/obo/GO_0070357 GO:0070354 biolink:CellularComponent GATA2-TAL1-TCF3-Lmo2 complex A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis. go.json http://purl.obolibrary.org/obo/GO_0070354 GO:0070355 biolink:CellularComponent synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof). go.json SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)|STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex http://purl.obolibrary.org/obo/GO_0070355 GO:0070352 biolink:BiologicalProcess positive regulation of white fat cell proliferation Any process that activates or increases the rate or extent of white fat cell proliferation. go.json activation of white fat cell proliferation|positive regulation of white adipocyte proliferation|positive regulation of white adipose cell proliferation|stimulation of white fat cell proliferation|up regulation of white fat cell proliferation|up-regulation of white fat cell proliferation|upregulation of white fat cell proliferation http://purl.obolibrary.org/obo/GO_0070352 GO:0070353 biolink:CellularComponent GATA1-TAL1-TCF3-Lmo2 complex A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis. go.json http://purl.obolibrary.org/obo/GO_0070353 GO:0070340 biolink:BiologicalProcess detection of bacterial lipopeptide The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0070340 GO:1901899 biolink:BiologicalProcess positive regulation of relaxation of cardiac muscle Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle. go.json activation of relaxation of cardiac muscle|up regulation of relaxation of cardiac muscle|up-regulation of relaxation of cardiac muscle|upregulation of relaxation of cardiac muscle http://purl.obolibrary.org/obo/GO_1901899 GO:1901897 biolink:BiologicalProcess regulation of relaxation of cardiac muscle Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle. go.json http://purl.obolibrary.org/obo/GO_1901897 GO:1901898 biolink:BiologicalProcess negative regulation of relaxation of cardiac muscle Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle. go.json down regulation of relaxation of cardiac muscle|down-regulation of relaxation of cardiac muscle|downregulation of relaxation of cardiac muscle|inhibition of relaxation of cardiac muscle http://purl.obolibrary.org/obo/GO_1901898 GO:1901895 biolink:BiologicalProcess negative regulation of ATPase-coupled calcium transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. go.json down regulation of ATP phosphohydrolase (Ca2+-transporting)|down regulation of Ca(2+)-transporting ATPase activity|down regulation of Ca2+-pumping ATPase activity|down regulation of Ca2+-transporting ATPase activity|down regulation of calcium ABC transporter|down regulation of calcium efflux ATPase|down regulation of calcium pump|down regulation of calcium transporting ATPase activity|down regulation of calcium-translocating P-type ATPase activity|down regulation of calcium-transporting ATPase activity|down regulation of plasma membrane Ca-ATPase|down regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|down regulation of sarcoplasmic reticulum ATPase|down-regulation of ATP phosphohydrolase (Ca2+-transporting)|down-regulation of Ca(2+)-transporting ATPase activity|down-regulation of Ca2+-pumping ATPase activity|down-regulation of Ca2+-transporting ATPase activity|down-regulation of calcium ABC transporter|down-regulation of calcium efflux ATPase|down-regulation of calcium pump|down-regulation of calcium transporting ATPase activity|down-regulation of calcium-translocating P-type ATPase activity|down-regulation of calcium-transporting ATPase activity|down-regulation of plasma membrane Ca-ATPase|down-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|down-regulation of sarcoplasmic reticulum ATPase|downregulation of ATP phosphohydrolase (Ca2+-transporting)|downregulation of Ca(2+)-transporting ATPase activity|downregulation of Ca2+-pumping ATPase activity|downregulation of Ca2+-transporting ATPase activity|downregulation of calcium ABC transporter|downregulation of calcium efflux ATPase|downregulation of calcium pump|downregulation of calcium transporting ATPase activity|downregulation of calcium-translocating P-type ATPase activity|downregulation of calcium-transporting ATPase activity|downregulation of plasma membrane Ca-ATPase|downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase|downregulation of sarcoplasmic reticulum ATPase|inhibition of ATP phosphohydrolase (Ca2+-transporting)|inhibition of Ca(2+)-transporting ATPase activity|inhibition of Ca2+-pumping ATPase activity|inhibition of Ca2+-transporting ATPase activity|inhibition of calcium ABC transporter|inhibition of calcium efflux ATPase|inhibition of calcium pump|inhibition of calcium transporting ATPase activity|inhibition of calcium-translocating P-type ATPase activity|inhibition of calcium-transporting ATPase activity|inhibition of plasma membrane Ca-ATPase|inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase|inhibition of sarcoplasmic reticulum ATPase|negative regulation of ATP phosphohydrolase (Ca2+-transporting)|negative regulation of Ca(2+)-transporting ATPase activity|negative regulation of Ca2+-pumping ATPase activity|negative regulation of Ca2+-transporting ATPase activity|negative regulation of calcium ABC transporter|negative regulation of calcium efflux ATPase|negative regulation of calcium pump|negative regulation of calcium transporting ATPase activity|negative regulation of calcium-translocating P-type ATPase activity|negative regulation of calcium-transporting ATPase activity|negative regulation of plasma membrane Ca-ATPase|negative regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|negative regulation of sarcoplasmic reticulum ATPase http://purl.obolibrary.org/obo/GO_1901895 gocheck_do_not_annotate GO:1901896 biolink:BiologicalProcess positive regulation of ATPase-coupled calcium transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. go.json activation of ATP phosphohydrolase (Ca2+-transporting)|activation of Ca(2+)-transporting ATPase activity|activation of Ca2+-pumping ATPase activity|activation of Ca2+-transporting ATPase activity|activation of calcium ABC transporter|activation of calcium efflux ATPase|activation of calcium pump|activation of calcium transporting ATPase activity|activation of calcium-translocating P-type ATPase activity|activation of calcium-transporting ATPase activity|activation of plasma membrane Ca-ATPase|activation of sarco(endo)plasmic reticulum Ca2+-ATPase|activation of sarcoplasmic reticulum ATPase|positive regulation of ATP phosphohydrolase (Ca2+-transporting)|positive regulation of Ca(2+)-transporting ATPase activity|positive regulation of Ca2+-pumping ATPase activity|positive regulation of Ca2+-transporting ATPase activity|positive regulation of calcium ABC transporter|positive regulation of calcium efflux ATPase|positive regulation of calcium pump|positive regulation of calcium transporting ATPase activity|positive regulation of calcium-translocating P-type ATPase activity|positive regulation of calcium-transporting ATPase activity|positive regulation of plasma membrane Ca-ATPase|positive regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|positive regulation of sarcoplasmic reticulum ATPase|up regulation of ATP phosphohydrolase (Ca2+-transporting)|up regulation of Ca(2+)-transporting ATPase activity|up regulation of Ca2+-pumping ATPase activity|up regulation of Ca2+-transporting ATPase activity|up regulation of calcium ABC transporter|up regulation of calcium efflux ATPase|up regulation of calcium pump|up regulation of calcium transporting ATPase activity|up regulation of calcium-translocating P-type ATPase activity|up regulation of calcium-transporting ATPase activity|up regulation of plasma membrane Ca-ATPase|up regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|up regulation of sarcoplasmic reticulum ATPase|up-regulation of ATP phosphohydrolase (Ca2+-transporting)|up-regulation of Ca(2+)-transporting ATPase activity|up-regulation of Ca2+-pumping ATPase activity|up-regulation of Ca2+-transporting ATPase activity|up-regulation of calcium ABC transporter|up-regulation of calcium efflux ATPase|up-regulation of calcium pump|up-regulation of calcium transporting ATPase activity|up-regulation of calcium-translocating P-type ATPase activity|up-regulation of calcium-transporting ATPase activity|up-regulation of plasma membrane Ca-ATPase|up-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|up-regulation of sarcoplasmic reticulum ATPase|upregulation of ATP phosphohydrolase (Ca2+-transporting)|upregulation of Ca(2+)-transporting ATPase activity|upregulation of Ca2+-pumping ATPase activity|upregulation of Ca2+-transporting ATPase activity|upregulation of calcium ABC transporter|upregulation of calcium efflux ATPase|upregulation of calcium pump|upregulation of calcium transporting ATPase activity|upregulation of calcium-translocating P-type ATPase activity|upregulation of calcium-transporting ATPase activity|upregulation of plasma membrane Ca-ATPase|upregulation of sarco(endo)plasmic reticulum Ca2+-ATPase|upregulation of sarcoplasmic reticulum ATPase http://purl.obolibrary.org/obo/GO_1901896 gocheck_do_not_annotate GO:1901893 biolink:BiologicalProcess positive regulation of cell septum assembly Any process that activates or increases the frequency, rate or extent of cell septum assembly. go.json activation of cell septum assembly|up regulation of cell septum assembly|up-regulation of cell septum assembly|upregulation of cell septum assembly http://purl.obolibrary.org/obo/GO_1901893 GO:1901894 biolink:BiologicalProcess regulation of ATPase-coupled calcium transmembrane transporter activity Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. go.json regulation of ATP phosphohydrolase (Ca2+-transporting)|regulation of Ca(2+)-transporting ATPase activity|regulation of Ca2+-pumping ATPase activity|regulation of Ca2+-transporting ATPase activity|regulation of calcium ABC transporter|regulation of calcium efflux ATPase|regulation of calcium pump|regulation of calcium transporting ATPase activity|regulation of calcium-translocating P-type ATPase activity|regulation of calcium-transporting ATPase activity|regulation of plasma membrane Ca-ATPase|regulation of sarco(endo)plasmic reticulum Ca2+-ATPase|regulation of sarcoplasmic reticulum ATPase http://purl.obolibrary.org/obo/GO_1901894 gocheck_do_not_annotate GO:1901891 biolink:BiologicalProcess regulation of cell septum assembly Any process that modulates the frequency, rate or extent of cell septum assembly. go.json http://purl.obolibrary.org/obo/GO_1901891 GO:1901892 biolink:BiologicalProcess negative regulation of cell septum assembly Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly. go.json down regulation of cell septum assembly|down-regulation of cell septum assembly|downregulation of cell septum assembly|inhibition of cell septum assembly http://purl.obolibrary.org/obo/GO_1901892 GO:0070349 biolink:BiologicalProcess positive regulation of brown fat cell proliferation Any process that activates or increases the rate or extent of brown fat cell proliferation. go.json activation of brown fat cell proliferation|positive regulation of brown adipocyte proliferation|positive regulation of brown adipose cell proliferation|stimulation of brown fat cell proliferation|up regulation of brown fat cell proliferation|up-regulation of brown fat cell proliferation|upregulation of brown fat cell proliferation http://purl.obolibrary.org/obo/GO_0070349 GO:0070347 biolink:BiologicalProcess regulation of brown fat cell proliferation Any process that modulates the frequency, rate or extent of brown fat cell proliferation. go.json regulation of brown adipocyte proliferation|regulation of brown adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070347 GO:0070348 biolink:BiologicalProcess negative regulation of brown fat cell proliferation Any process that stops or decreases the rate or extent of brown fat cell proliferation. go.json down regulation of brown fat cell proliferation|down-regulation of brown fat cell proliferation|downregulation of brown fat cell proliferation|inhibition of brown fat cell proliferation|negative regulation of brown adipocyte proliferation|negative regulation of brown adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070348 GO:0070345 biolink:BiologicalProcess negative regulation of fat cell proliferation Any process that stops or decreases the rate or extent of fat cell proliferation. go.json down regulation of fat cell proliferation|down-regulation of fat cell proliferation|downregulation of fat cell proliferation|inhibition of fat cell proliferation|negative regulation of adipocyte proliferation|negative regulation of adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070345 GO:0070346 biolink:BiologicalProcess positive regulation of fat cell proliferation Any process that activates or increases the rate or extent of fat cell proliferation. go.json activation of fat cell proliferation|positive regulation of adipocyte proliferation|positive regulation of adipose cell proliferation|stimulation of fat cell proliferation|up regulation of fat cell proliferation|up-regulation of fat cell proliferation|upregulation of fat cell proliferation http://purl.obolibrary.org/obo/GO_0070346 GO:0070343 biolink:BiologicalProcess white fat cell proliferation The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population. go.json white adipocyte proliferation|white adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070343 GO:0070344 biolink:BiologicalProcess regulation of fat cell proliferation Any process that modulates the frequency, rate or extent of fat cell proliferation. go.json regulation of adipocyte proliferation|regulation of adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070344 GO:0070341 biolink:BiologicalProcess fat cell proliferation The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. go.json adipocyte proliferation|adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070341 GO:0070342 biolink:BiologicalProcess brown fat cell proliferation The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species. go.json brown adipocyte proliferation|brown adipose cell proliferation http://purl.obolibrary.org/obo/GO_0070342 GO:0070372 biolink:BiologicalProcess regulation of ERK1 and ERK2 cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. go.json regulation of ERK cascade|regulation of ERK1 and ERK2 signaling pathway|regulation of ERK1 and ERK2 signalling pathway|regulation of ERK1 cascade|regulation of ERK1/2 cascade|regulation of ERK2 cascade|regulation of MAPK1 cascade|regulation of MAPK3 cascade http://purl.obolibrary.org/obo/GO_0070372 GO:0070373 biolink:BiologicalProcess negative regulation of ERK1 and ERK2 cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. go.json down regulation of ERK1 and ERK2 cascade|down-regulation of ERK1 and ERK2 cascade|downregulation of ERK1 and ERK2 cascade|inhibition of ERK1 and ERK2 cascade|negative regulation of ERK cascade|negative regulation of ERK1 and ERK2 signaling pathway|negative regulation of ERK1 and ERK2 signalling pathway|negative regulation of ERK1 cascade|negative regulation of ERK1/2 cascade|negative regulation of ERK2 cascade|negative regulation of MAPK1 cascade|negative regulation of MAPK3 cascade http://purl.obolibrary.org/obo/GO_0070373 GO:0070370 biolink:BiologicalProcess cellular heat acclimation Any process that increases heat tolerance of a cell in response to high temperatures. go.json cellular thermotolerance http://purl.obolibrary.org/obo/GO_0070370 GO:0070371 biolink:BiologicalProcess ERK1 and ERK2 cascade An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. go.json ERK cascade|ERK1 and ERK2 signaling pathway|ERK1 and ERK2 signalling pathway|ERK1 cascade|ERK1/2 cascade|ERK2 cascade|MAPK1 cascade|MAPK3 cascade|extracellular signal-regulated kinase 1/2 (ERK1/2) cascade|extracellular signal-regulated kinase 1/2 cascade http://purl.obolibrary.org/obo/GO_0070371 GO:0070378 biolink:BiologicalProcess positive regulation of ERK5 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. go.json activation of BMK cascade|positive regulation of BMK cascade|positive regulation of BMK signaling pathway|positive regulation of BMK signalling pathway|positive regulation of BMK1 cascade|positive regulation of ERK5 signaling pathway|positive regulation of MAPK7 cascade|stimulation of BMK cascade|up regulation of BMK cascade|up-regulation of BMK cascade|upregulation of BMK cascade http://purl.obolibrary.org/obo/GO_0070378 GO:0070379 biolink:MolecularActivity high mobility group box 1 binding Binding to high mobility group box 1 (HMBGB1). go.json HMGB1 binding http://purl.obolibrary.org/obo/GO_0070379 GO:0070376 biolink:BiologicalProcess regulation of ERK5 cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. go.json regulation of BMK cascade|regulation of BMK signaling pathway|regulation of BMK signalling pathway|regulation of BMK1 cascade|regulation of ERK5 signaling pathway|regulation of MAPK7 cascade http://purl.obolibrary.org/obo/GO_0070376 GO:0070377 biolink:BiologicalProcess negative regulation of ERK5 cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. go.json down regulation of BMK cascade|down-regulation of BMK cascade|downregulation of BMK cascade|inhibition of BMK cascade|negative regulation of BMK cascade|negative regulation of BMK signaling pathway|negative regulation of BMK signalling pathway|negative regulation of BMK1 cascade|negative regulation of ERK5 signaling pathway|negative regulation of MAPK7 cascade http://purl.obolibrary.org/obo/GO_0070377 GO:0070374 biolink:BiologicalProcess positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. go.json activation of ERK1 and ERK2 cascade|positive regulation of ERK cascade|positive regulation of ERK1 and ERK2 signaling pathway|positive regulation of ERK1 and ERK2 signalling pathway|positive regulation of ERK1 cascade|positive regulation of ERK1/2 cascade|positive regulation of ERK2 cascade|positive regulation of MAPK1 cascade|positive regulation of MAPK3 cascade|stimulation of ERK1 and ERK2 cascade|up regulation of ERK1 and ERK2 cascade|up-regulation of ERK1 and ERK2 cascade|upregulation of ERK1 and ERK2 cascade http://purl.obolibrary.org/obo/GO_0070374 GO:0070375 biolink:BiologicalProcess ERK5 cascade An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. go.json BMK cascade|BMK signaling pathway|BMK signalling pathway|BMK1 cascade|ERK5 signaling pathway|MAPK7 cascade|big MAP kinase signaling cascade|extracellular signal-regulated kinase 5 cascade http://purl.obolibrary.org/obo/GO_0070375 GO:0070361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070361 GO:0070362 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070362 GO:0070360 biolink:BiologicalProcess actin polymerization-dependent cell migration in host The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of actin at one pole of the symbiont cell. Some bacteria use host actin for migration. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json actin polymerization-dependent cell motility involved in migration of symbiont in host|migration of symbiont within host by polymerization of host actin http://purl.obolibrary.org/obo/GO_0070360 GO:0070369 biolink:CellularComponent beta-catenin-TCF7L2 complex A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. go.json beta-catenin-TCF4 complex http://purl.obolibrary.org/obo/GO_0070369 GO:0070367 biolink:BiologicalProcess negative regulation of hepatocyte differentiation Any process that stops or decreases the rate or extent of hepatocyte differentiation. go.json down regulation of hepatocyte differentiation|down-regulation of hepatocyte differentiation|downregulation of hepatocyte differentiation|inhibition of hepatocyte differentiation|negative regulation of liver cell differentiation http://purl.obolibrary.org/obo/GO_0070367 GO:0070368 biolink:BiologicalProcess positive regulation of hepatocyte differentiation Any process that activates or increases the rate or extent of hepatocyte differentiation. go.json activation of hepatocyte differentiation|positive regulation of liver cell differentiation|stimulation of hepatocyte differentiation|up regulation of hepatocyte differentiation|up-regulation of hepatocyte differentiation|upregulation of hepatocyte differentiation http://purl.obolibrary.org/obo/GO_0070368 GO:0070365 biolink:BiologicalProcess hepatocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. go.json liver cell differentiation http://purl.obolibrary.org/obo/GO_0070365 GO:0070366 biolink:BiologicalProcess regulation of hepatocyte differentiation Any process that modulates the frequency, rate or extent of hepatocyte differentiation. go.json regulation of liver cell differentiation http://purl.obolibrary.org/obo/GO_0070366 GO:0070363 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070363 GO:0070364 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070364 GO:0021540 biolink:BiologicalProcess corpus callosum morphogenesis The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres. go.json http://purl.obolibrary.org/obo/GO_0021540 GO:0021541 biolink:BiologicalProcess ammon gyrus development The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons. go.json Ammon's horn development|cornu ammonis development http://purl.obolibrary.org/obo/GO_0021541 GO:0021542 biolink:BiologicalProcess dentate gyrus development The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. go.json http://purl.obolibrary.org/obo/GO_0021542 GO:0021543 biolink:BiologicalProcess pallium development The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0021543 GO:0021544 biolink:BiologicalProcess subpallium development The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0021544 GO:0045512 biolink:MolecularActivity interleukin-26 binding Binding to interleukin-26. go.json IL-26 binding http://purl.obolibrary.org/obo/GO_0045512 GO:0045513 biolink:MolecularActivity interleukin-27 binding Binding to interleukin-27. go.json IL-27 binding http://purl.obolibrary.org/obo/GO_0045513 GO:0045510 biolink:MolecularActivity interleukin-24 binding Binding to interleukin-24. go.json IL-24 binding http://purl.obolibrary.org/obo/GO_0045510 GO:0045511 biolink:MolecularActivity interleukin-25 binding Binding to interleukin-25. go.json IL-25 binding http://purl.obolibrary.org/obo/GO_0045511 GO:0045518 biolink:MolecularActivity interleukin-22 receptor binding Binding to an interleukin-22 receptor. go.json IL-22|interleukin-22 receptor ligand http://purl.obolibrary.org/obo/GO_0045518 GO:0045519 biolink:MolecularActivity interleukin-23 receptor binding Binding to an interleukin-23 receptor. go.json IL-23|interleukin-23 receptor ligand http://purl.obolibrary.org/obo/GO_0045519 GO:0045516 biolink:MolecularActivity interleukin-19 receptor binding Binding to an interleukin-19 receptor. go.json IL-19|interleukin-19 receptor ligand http://purl.obolibrary.org/obo/GO_0045516 GO:0045517 biolink:MolecularActivity interleukin-20 receptor binding Binding to an interleukin-20 receptor. go.json IL-20|interleukin-20 receptor ligand http://purl.obolibrary.org/obo/GO_0045517 GO:0045514 biolink:MolecularActivity interleukin-16 receptor binding Binding to an interleukin-16 receptor. go.json IL-16|interleukin-16 receptor ligand http://purl.obolibrary.org/obo/GO_0045514 GO:0045515 biolink:MolecularActivity interleukin-18 receptor binding Binding to an interleukin-18 receptor. go.json IL-18|interleukin-18 receptor ligand http://purl.obolibrary.org/obo/GO_0045515 GO:0021545 biolink:BiologicalProcess cranial nerve development The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. go.json http://purl.obolibrary.org/obo/GO_0021545 GO:0021546 biolink:BiologicalProcess rhombomere development The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. go.json http://purl.obolibrary.org/obo/GO_0021546 GO:0021547 biolink:BiologicalProcess midbrain-hindbrain boundary initiation The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. go.json MHB biosynthesis|MHB formation|isthmus biosynthesis|isthmus formation|midbrain-hindbrain boundary biosynthesis|midbrain-hindbrain boundary formation http://purl.obolibrary.org/obo/GO_0021547 GO:0021548 biolink:BiologicalProcess pons development The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. go.json http://purl.obolibrary.org/obo/GO_0021548 GO:0021549 biolink:BiologicalProcess cerebellum development The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. go.json http://purl.obolibrary.org/obo/GO_0021549 GO:0021530 biolink:BiologicalProcess spinal cord oligodendrocyte cell fate specification The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. go.json http://purl.obolibrary.org/obo/GO_0021530 GO:0021531 biolink:BiologicalProcess spinal cord radial glial cell differentiation The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json radial glial cell differentiation in spinal cord http://purl.obolibrary.org/obo/GO_0021531 GO:0021532 biolink:BiologicalProcess neural tube patterning The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. go.json http://purl.obolibrary.org/obo/GO_0021532 GO:0021533 biolink:BiologicalProcess cell differentiation in hindbrain The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021533 GO:0045523 biolink:MolecularActivity interleukin-27 receptor binding Binding to an interleukin-27 receptor. go.json IL-27|interleukin-27 receptor ligand http://purl.obolibrary.org/obo/GO_0045523 GO:0045524 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045524 GO:0045521 biolink:MolecularActivity interleukin-25 receptor binding Binding to an interleukin-25 receptor. go.json IL-25|interleukin-25 receptor ligand http://purl.obolibrary.org/obo/GO_0045521 GO:0045522 biolink:MolecularActivity interleukin-26 receptor binding Binding to an interleukin-26 receptor. go.json IL-26|interleukin-26 receptor ligand http://purl.obolibrary.org/obo/GO_0045522 GO:0045520 biolink:MolecularActivity interleukin-24 receptor binding Binding to an interleukin-24 receptor. go.json IL-24|interleukin-24 receptor ligand http://purl.obolibrary.org/obo/GO_0045520 GO:0045529 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045529 GO:0045527 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045527 GO:0045528 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045528 GO:0045525 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045525 GO:0045526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045526 GO:0021534 biolink:BiologicalProcess cell proliferation in hindbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. go.json http://purl.obolibrary.org/obo/GO_0021534 GO:0021535 biolink:BiologicalProcess cell migration in hindbrain The orderly movement of a cell that will reside in the hindbrain. go.json http://purl.obolibrary.org/obo/GO_0021535 GO:0021536 biolink:BiologicalProcess diencephalon development The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0021536 GO:0021537 biolink:BiologicalProcess telencephalon development The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. go.json cerebrum development http://purl.obolibrary.org/obo/GO_0021537 GO:0021538 biolink:BiologicalProcess epithalamus development The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle. go.json http://purl.obolibrary.org/obo/GO_0021538 GO:0021539 biolink:BiologicalProcess subthalamus development The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis. go.json ventral thalamus development http://purl.obolibrary.org/obo/GO_0021539 GO:0021520 biolink:BiologicalProcess spinal cord motor neuron cell fate specification The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. go.json http://purl.obolibrary.org/obo/GO_0021520 GO:0021521 biolink:BiologicalProcess ventral spinal cord interneuron specification The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. go.json http://purl.obolibrary.org/obo/GO_0021521 GO:0021522 biolink:BiologicalProcess spinal cord motor neuron differentiation The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021522 GO:0045534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045534 GO:0045535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045535 GO:0045532 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045532 GO:0045533 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045533 GO:0045530 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045530 GO:0045531 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045531 GO:0045538 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045538 GO:0045539 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045539 GO:0045536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045536 GO:0045537 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045537 GO:0021523 biolink:BiologicalProcess somatic motor neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021523 GO:0021524 biolink:BiologicalProcess visceral motor neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021524 GO:0021525 biolink:BiologicalProcess lateral motor column neuron differentiation The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021525 GO:0021526 biolink:BiologicalProcess medial motor column neuron differentiation The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021526 GO:0021527 biolink:BiologicalProcess spinal cord association neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json spinal cord dorsal interneuron differentiation http://purl.obolibrary.org/obo/GO_0021527 GO:0021528 biolink:BiologicalProcess commissural neuron differentiation in spinal cord The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021528 GO:0021529 biolink:BiologicalProcess spinal cord oligodendrocyte cell differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021529 GO:0021510 biolink:BiologicalProcess spinal cord development The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. go.json http://purl.obolibrary.org/obo/GO_0021510 GO:0021511 biolink:BiologicalProcess spinal cord patterning The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0021511 GO:0045545 biolink:MolecularActivity syndecan binding Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0045545 GO:0045546 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045546 GO:0045543 biolink:MolecularActivity gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2. EC:1.14.11.13|RHEA:15005 go.json gibberellin 2-beta-hydroxylase activity|gibberellin 2-oxidase activity|gibberellin 2beta-dioxygenase activity|gibberellin 2beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0045543 GO:0045544 biolink:MolecularActivity gibberellin 20-oxidase activity Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones. go.json http://purl.obolibrary.org/obo/GO_0045544 GO:0045541 biolink:BiologicalProcess negative regulation of cholesterol biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. go.json down regulation of cholesterol biosynthetic process|down-regulation of cholesterol biosynthetic process|downregulation of cholesterol biosynthetic process|inhibition of cholesterol biosynthetic process|negative regulation of cholesterol anabolism|negative regulation of cholesterol biosynthesis|negative regulation of cholesterol formation|negative regulation of cholesterol synthesis http://purl.obolibrary.org/obo/GO_0045541 GO:0045542 biolink:BiologicalProcess positive regulation of cholesterol biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. go.json activation of cholesterol biosynthetic process|positive regulation of cholesterol anabolism|positive regulation of cholesterol biosynthesis|positive regulation of cholesterol formation|positive regulation of cholesterol synthesis|stimulation of cholesterol biosynthetic process|up regulation of cholesterol biosynthetic process|up-regulation of cholesterol biosynthetic process|upregulation of cholesterol biosynthetic process http://purl.obolibrary.org/obo/GO_0045542 GO:0045540 biolink:BiologicalProcess regulation of cholesterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. go.json regulation of cholesterol anabolism|regulation of cholesterol biosynthesis|regulation of cholesterol formation|regulation of cholesterol synthesis http://purl.obolibrary.org/obo/GO_0045540 GO:0045549 biolink:MolecularActivity 9-cis-epoxycarotenoid dioxygenase activity Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al. EC:1.13.11.51 go.json 9-cis-epoxycarotenoid 11,12-dioxygenase activity|AtNCED3|NCED|PvNCED1|VP14|neoxanthin cleavage enzyme|nine-cis-epoxycarotenoid dioxygenase activity http://purl.obolibrary.org/obo/GO_0045549 GO:0045547 biolink:MolecularActivity dehydrodolichyl diphosphate synthase activity Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. EC:2.5.1.87|RHEA:53008 go.json http://purl.obolibrary.org/obo/GO_0045547 GO:0045548 biolink:MolecularActivity phenylalanine ammonia-lyase activity Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate. EC:4.3.1.24|EC:4.3.1.25|RHEA:21384 go.json L-phenylalanine ammonia-lyase activity|PAL activity|phe ammonia-lyase activity|phenylalanine ammonium-lyase activity|phenylalanine deaminase activity http://purl.obolibrary.org/obo/GO_0045548 GO:0021512 biolink:BiologicalProcess spinal cord anterior/posterior patterning The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord. go.json spinal cord anterior-posterior patterning|spinal cord rostrocaudal patterning http://purl.obolibrary.org/obo/GO_0021512 GO:0021513 biolink:BiologicalProcess spinal cord dorsal/ventral patterning The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. go.json spinal cord dorsal-ventral patterning|spinal cord dorsoventral patterning http://purl.obolibrary.org/obo/GO_0021513 GO:0021514 biolink:BiologicalProcess ventral spinal cord interneuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021514 GO:0021515 biolink:BiologicalProcess cell differentiation in spinal cord The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0021515 GO:0021516 biolink:BiologicalProcess dorsal spinal cord development The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. go.json http://purl.obolibrary.org/obo/GO_0021516 GO:0021517 biolink:BiologicalProcess ventral spinal cord development The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. go.json http://purl.obolibrary.org/obo/GO_0021517 GO:0021518 biolink:BiologicalProcess spinal cord commissural neuron specification The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway. go.json http://purl.obolibrary.org/obo/GO_0021518 GO:0021519 biolink:BiologicalProcess spinal cord association neuron specification The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway. go.json http://purl.obolibrary.org/obo/GO_0021519 GO:0045556 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045556 GO:0045557 biolink:BiologicalProcess obsolete TRAIL receptor biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. go.json TRAIL receptor anabolism|TRAIL receptor biosynthesis|TRAIL receptor formation|TRAIL receptor synthesis True http://purl.obolibrary.org/obo/GO_0045557 GO:0045554 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045554 GO:0045555 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045555 GO:0045552 biolink:MolecularActivity dihydrokaempferol 4-reductase activity Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. EC:1.1.1.219|MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN|RHEA:23016 go.json NADPH-dihydromyricetin reductase activity|cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity|dihydroflavanol 4-reductase activity|dihydroflavonol 4-reductase activity|dihydromyricetin reductase activity|dihydroquercetin reductase activity http://purl.obolibrary.org/obo/GO_0045552 GO:0045553 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045553 GO:0045550 biolink:MolecularActivity geranylgeranyl reductase activity Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. go.json http://purl.obolibrary.org/obo/GO_0045550 GO:0045551 biolink:MolecularActivity cinnamyl-alcohol dehydrogenase activity Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. EC:1.1.1.195|MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN|RHEA:10392 go.json CAD activity|cinnamyl alcohol dehydrogenase activity|cinnamyl-alcohol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0045551 GO:0021509 biolink:BiologicalProcess roof plate formation The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells. go.json http://purl.obolibrary.org/obo/GO_0021509 GO:0070518 biolink:CellularComponent alpha4-beta1 integrin-CD53 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family. go.json ITGA4-ITGB1-CD53 complex http://purl.obolibrary.org/obo/GO_0070518 GO:0070519 biolink:CellularComponent alpha4-beta1 integrin-CD63 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family. go.json ITGA4-ITGB1-CD63 complex http://purl.obolibrary.org/obo/GO_0070519 GO:0070516 biolink:CellularComponent CAK-ERCC2 complex A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2. go.json cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex http://purl.obolibrary.org/obo/GO_0070516 GO:0070517 biolink:CellularComponent DNA replication factor C core complex A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37. go.json RFC core complex http://purl.obolibrary.org/obo/GO_0070517 GO:0045558 biolink:BiologicalProcess obsolete TRAIL receptor 1 biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway. go.json TRAIL receptor 1 anabolism|TRAIL receptor 1 biosynthesis|TRAIL receptor 1 formation|TRAIL receptor 1 synthesis|tumor necrosis factor receptor superfamily member 10A biosynthetic process True http://purl.obolibrary.org/obo/GO_0045558 GO:0070514 biolink:CellularComponent SRF-myogenin-E12 complex A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes. go.json http://purl.obolibrary.org/obo/GO_0070514 GO:0070515 biolink:CellularComponent alphaIIb-beta3 integrin-talin complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin. go.json ITGA2b-ITGB3-TLN1 complex http://purl.obolibrary.org/obo/GO_0070515 GO:0045559 biolink:BiologicalProcess obsolete TRAIL receptor 2 biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. go.json TRAIL receptor 2 anabolism|TRAIL receptor 2 biosynthesis|TRAIL receptor 2 formation|TRAIL receptor 2 synthesis|tumor necrosis factor receptor superfamily member 10B biosynthetic process True http://purl.obolibrary.org/obo/GO_0045559 GO:0070512 biolink:BiologicalProcess positive regulation of histone H4-K20 methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. go.json activation of histone H4-K20 methylation|stimulation of histone H4-K20 methylation|up regulation of histone H4-K20 methylation|up-regulation of histone H4-K20 methylation|upregulation of histone H4-K20 methylation http://purl.obolibrary.org/obo/GO_0070512 GO:0021501 biolink:BiologicalProcess prechordal plate formation The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. go.json http://purl.obolibrary.org/obo/GO_0021501 GO:0070513 biolink:MolecularActivity death domain binding Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. go.json http://purl.obolibrary.org/obo/GO_0070513 GO:0021502 biolink:BiologicalProcess neural fold elevation formation The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm. go.json http://purl.obolibrary.org/obo/GO_0021502 GO:0070510 biolink:BiologicalProcess obsolete regulation of histone H4-K20 methylation OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. go.json True http://purl.obolibrary.org/obo/GO_0070510 GO:0021503 biolink:BiologicalProcess neural fold bending The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse. go.json http://purl.obolibrary.org/obo/GO_0021503 GO:0070511 biolink:BiologicalProcess obsolete negative regulation of histone H4-K20 methylation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. go.json down regulation of histone H4-K20 methylation|down-regulation of histone H4-K20 methylation|downregulation of histone H4-K20 methylation|inhibition of histone H4-K20 methylation True http://purl.obolibrary.org/obo/GO_0070511 GO:0021504 biolink:BiologicalProcess neural fold hinge point formation The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube. go.json neural fold furrowing http://purl.obolibrary.org/obo/GO_0021504 GO:0021505 biolink:BiologicalProcess neural fold folding The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds. go.json http://purl.obolibrary.org/obo/GO_0021505 GO:0021506 biolink:BiologicalProcess anterior neuropore closure The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. go.json http://purl.obolibrary.org/obo/GO_0021506 GO:0021507 biolink:BiologicalProcess posterior neuropore closure The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete. go.json http://purl.obolibrary.org/obo/GO_0021507 GO:0021508 biolink:BiologicalProcess floor plate formation The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. go.json http://purl.obolibrary.org/obo/GO_0021508 GO:0045560 biolink:BiologicalProcess obsolete regulation of TRAIL receptor biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. go.json regulation of TRAIL receptor anabolism|regulation of TRAIL receptor biosynthesis|regulation of TRAIL receptor formation|regulation of TRAIL receptor synthesis True http://purl.obolibrary.org/obo/GO_0045560 GO:0045567 biolink:BiologicalProcess obsolete negative regulation of TRAIL receptor 2 biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2. go.json down regulation of TRAIL receptor 2 biosynthetic process|down-regulation of TRAIL receptor 2 biosynthetic process|downregulation of TRAIL receptor 2 biosynthetic process|inhibition of TRAIL receptor 2 biosynthetic process|negative regulation of TRAIL receptor 2 anabolism|negative regulation of TRAIL receptor 2 biosynthesis|negative regulation of TRAIL receptor 2 formation|negative regulation of TRAIL receptor 2 synthesis True http://purl.obolibrary.org/obo/GO_0045567 GO:0045568 biolink:BiologicalProcess obsolete positive regulation of TRAIL receptor 2 biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2. go.json activation of TRAIL receptor 2 biosynthetic process|positive regulation of TRAIL receptor 2 anabolism|positive regulation of TRAIL receptor 2 biosynthesis|positive regulation of TRAIL receptor 2 formation|positive regulation of TRAIL receptor 2 synthesis|stimulation of TRAIL receptor 2 biosynthetic process|up regulation of TRAIL receptor 2 biosynthetic process|up-regulation of TRAIL receptor 2 biosynthetic process|upregulation of TRAIL receptor 2 biosynthetic process True http://purl.obolibrary.org/obo/GO_0045568 GO:0045565 biolink:BiologicalProcess obsolete negative regulation of TRAIL receptor 1 biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1. go.json down regulation of TRAIL receptor 1 biosynthetic process|down-regulation of TRAIL receptor 1 biosynthetic process|downregulation of TRAIL receptor 1 biosynthetic process|inhibition of TRAIL receptor 1 biosynthetic process|negative regulation of TRAIL receptor 1 anabolism|negative regulation of TRAIL receptor 1 biosynthesis|negative regulation of TRAIL receptor 1 formation|negative regulation of TRAIL receptor 1 synthesis True http://purl.obolibrary.org/obo/GO_0045565 GO:0045566 biolink:BiologicalProcess obsolete positive regulation of TRAIL receptor 1 biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1. go.json activation of TRAIL receptor 1 biosynthetic process|positive regulation of TRAIL receptor 1 anabolism|positive regulation of TRAIL receptor 1 biosynthesis|positive regulation of TRAIL receptor 1 formation|positive regulation of TRAIL receptor 1 synthesis|stimulation of TRAIL receptor 1 biosynthetic process|up regulation of TRAIL receptor 1 biosynthetic process|up-regulation of TRAIL receptor 1 biosynthetic process|upregulation of TRAIL receptor 1 biosynthetic process True http://purl.obolibrary.org/obo/GO_0045566 GO:0045563 biolink:BiologicalProcess obsolete negative regulation of TRAIL receptor biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. go.json down regulation of TRAIL receptor biosynthetic process|down-regulation of TRAIL receptor biosynthetic process|downregulation of TRAIL receptor biosynthetic process|inhibition of TRAIL receptor biosynthetic process|negative regulation of TRAIL receptor anabolism|negative regulation of TRAIL receptor biosynthesis|negative regulation of TRAIL receptor formation|negative regulation of TRAIL receptor synthesis True http://purl.obolibrary.org/obo/GO_0045563 GO:0045564 biolink:BiologicalProcess obsolete positive regulation of TRAIL receptor biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. go.json activation of TRAIL receptor biosynthetic process|positive regulation of TRAIL receptor anabolism|positive regulation of TRAIL receptor biosynthesis|positive regulation of TRAIL receptor formation|positive regulation of TRAIL receptor synthesis|stimulation of TRAIL receptor biosynthetic process|up regulation of TRAIL receptor biosynthetic process|up-regulation of TRAIL receptor biosynthetic process|upregulation of TRAIL receptor biosynthetic process True http://purl.obolibrary.org/obo/GO_0045564 GO:0045561 biolink:BiologicalProcess obsolete regulation of TRAIL receptor 1 biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1. go.json regulation of TRAIL receptor 1 anabolism|regulation of TRAIL receptor 1 biosynthesis|regulation of TRAIL receptor 1 formation|regulation of TRAIL receptor 1 synthesis True http://purl.obolibrary.org/obo/GO_0045561 GO:0045562 biolink:BiologicalProcess obsolete regulation of TRAIL receptor 2 biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2. go.json regulation of TRAIL receptor 2 anabolism|regulation of TRAIL receptor 2 biosynthesis|regulation of TRAIL receptor 2 formation|regulation of TRAIL receptor 2 synthesis True http://purl.obolibrary.org/obo/GO_0045562 GO:0070509 biolink:BiologicalProcess calcium ion import The directed movement of calcium ions into a cell or organelle. go.json calcium ion uptake|transmembrane calcium influx http://purl.obolibrary.org/obo/GO_0070509 GO:0070507 biolink:BiologicalProcess regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. go.json regulation of microtubule cytoskeleton organisation|regulation of microtubule dynamics http://purl.obolibrary.org/obo/GO_0070507 GO:0070508 biolink:BiologicalProcess cholesterol import The directed movement of cholesterol into a cell or organelle. go.json cholesterol uptake http://purl.obolibrary.org/obo/GO_0070508 GO:0070505 biolink:CellularComponent pollen coat A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma. go.json pollenkitt|tryphine http://purl.obolibrary.org/obo/GO_0070505 GO:0070506 biolink:MolecularActivity high-density lipoprotein particle receptor activity Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis. go.json HDL receptor|high-density lipoprotein receptor activity http://purl.obolibrary.org/obo/GO_0070506 GO:0070503 biolink:BiologicalProcess selenium-containing prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments. go.json selenium-containing prosthetic group metabolism http://purl.obolibrary.org/obo/GO_0070503 GO:0045569 biolink:MolecularActivity TRAIL binding Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. go.json Apo-2L binding http://purl.obolibrary.org/obo/GO_0045569 goslim_chembl GO:0070504 biolink:BiologicalProcess selenium-containing prosthetic group biosynthetic process The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments. go.json selenium-containing prosthetic group anabolism|selenium-containing prosthetic group biosynthesis|selenium-containing prosthetic group formation|selenium-containing prosthetic group synthesis http://purl.obolibrary.org/obo/GO_0070504 GO:0070501 biolink:BiologicalProcess poly-gamma-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds. go.json poly-gamma-glutamate anabolism|poly-gamma-glutamate biosynthesis|poly-gamma-glutamate formation|poly-gamma-glutamate synthesis http://purl.obolibrary.org/obo/GO_0070501 GO:0070502 biolink:BiologicalProcess capsule poly-gamma-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule. go.json capsular poly-gamma-glutamate biosynthetic process|capsule poly-gamma-glutamate anabolism|capsule poly-gamma-glutamate biosynthesis|capsule poly-gamma-glutamate formation|capsule poly-gamma-glutamate synthesis http://purl.obolibrary.org/obo/GO_0070502 GO:0070500 biolink:BiologicalProcess obsolete poly-gamma-glutamate metabolic process OBSOLETE. The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds. go.json poly-gamma-glutamate metabolism True http://purl.obolibrary.org/obo/GO_0070500 GO:0045570 biolink:BiologicalProcess regulation of imaginal disc growth Any process that modulates the frequency, rate or extent of the growth of the imaginal disc. go.json http://purl.obolibrary.org/obo/GO_0045570 GO:0045571 biolink:BiologicalProcess negative regulation of imaginal disc growth Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth. go.json down regulation of imaginal disc growth|down-regulation of imaginal disc growth|downregulation of imaginal disc growth|inhibition of imaginal disc growth http://purl.obolibrary.org/obo/GO_0045571 GO:0045578 biolink:BiologicalProcess negative regulation of B cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. go.json down regulation of B cell differentiation|down-regulation of B cell differentiation|downregulation of B cell differentiation|inhibition of B cell differentiation|negative regulation of B cell development|negative regulation of B lymphocyte differentiation|negative regulation of B-cell differentiation|negative regulation of B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045578 GO:0045579 biolink:BiologicalProcess positive regulation of B cell differentiation Any process that activates or increases the frequency, rate or extent of B cell differentiation. go.json activation of B cell differentiation|positive regulation of B cell development|positive regulation of B lymphocyte differentiation|positive regulation of B-cell differentiation|positive regulation of B-lymphocyte differentiation|stimulation of B cell differentiation|up regulation of B cell differentiation|up-regulation of B cell differentiation|upregulation of B cell differentiation http://purl.obolibrary.org/obo/GO_0045579 GO:0045576 biolink:BiologicalProcess mast cell activation The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. go.json http://purl.obolibrary.org/obo/GO_0045576 GO:0045577 biolink:BiologicalProcess regulation of B cell differentiation Any process that modulates the frequency, rate or extent of B cell differentiation. go.json regulation of B cell development|regulation of B lymphocyte differentiation|regulation of B-cell differentiation|regulation of B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045577 GO:0045574 biolink:BiologicalProcess sterigmatocystin catabolic process The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. go.json sterigmatocystin breakdown|sterigmatocystin catabolism|sterigmatocystin degradation http://purl.obolibrary.org/obo/GO_0045574 GO:0045575 biolink:BiologicalProcess basophil activation The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors. Wikipedia:Basophil_activation go.json http://purl.obolibrary.org/obo/GO_0045575 GO:0045572 biolink:BiologicalProcess positive regulation of imaginal disc growth Any process that activates or increases the frequency, rate or extent of imaginal disc growth. go.json activation of imaginal disc growth|stimulation of imaginal disc growth|up regulation of imaginal disc growth|up-regulation of imaginal disc growth|upregulation of imaginal disc growth http://purl.obolibrary.org/obo/GO_0045572 GO:0045573 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045573 GO:0070538 biolink:MolecularActivity oleic acid binding Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. go.json http://purl.obolibrary.org/obo/GO_0070538 GO:0070539 biolink:MolecularActivity linoleic acid binding Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. go.json http://purl.obolibrary.org/obo/GO_0070539 GO:0070536 biolink:BiologicalProcess protein K63-linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. go.json http://purl.obolibrary.org/obo/GO_0070536 gocheck_do_not_annotate GO:0070537 biolink:BiologicalProcess histone H2A K63-linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX. go.json http://purl.obolibrary.org/obo/GO_0070537 GO:0070534 biolink:BiologicalProcess protein K63-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. go.json protein K63-linked polyubiquitination http://purl.obolibrary.org/obo/GO_0070534 GO:0070535 biolink:BiologicalProcess histone H2A K63-linked ubiquitination A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX. go.json http://purl.obolibrary.org/obo/GO_0070535 gocheck_do_not_annotate GO:0070532 biolink:CellularComponent BRCA1-B complex A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites. go.json http://purl.obolibrary.org/obo/GO_0070532 GO:0070533 biolink:CellularComponent BRCA1-C complex A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint. go.json http://purl.obolibrary.org/obo/GO_0070533 GO:0070530 biolink:MolecularActivity K63-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. go.json http://purl.obolibrary.org/obo/GO_0070530 GO:0070531 biolink:CellularComponent BRCA1-A complex A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. go.json http://purl.obolibrary.org/obo/GO_0070531 GO:0045581 biolink:BiologicalProcess negative regulation of T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. go.json down regulation of T cell differentiation|down-regulation of T cell differentiation|downregulation of T cell differentiation|inhibition of T cell differentiation|negative regulation of T cell development|negative regulation of T lymphocyte differentiation|negative regulation of T-cell differentiation|negative regulation of T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045581 GO:0045582 biolink:BiologicalProcess positive regulation of T cell differentiation Any process that activates or increases the frequency, rate or extent of T cell differentiation. go.json activation of T cell differentiation|positive regulation of T cell development|positive regulation of T lymphocyte differentiation|positive regulation of T-cell differentiation|positive regulation of T-lymphocyte differentiation|stimulation of T cell differentiation|up regulation of T cell differentiation|up-regulation of T cell differentiation|upregulation of T cell differentiation http://purl.obolibrary.org/obo/GO_0045582 GO:0045580 biolink:BiologicalProcess regulation of T cell differentiation Any process that modulates the frequency, rate or extent of T cell differentiation. go.json regulation of T cell development|regulation of T lymphocyte differentiation|regulation of T-cell differentiation|regulation of T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045580 GO:0045589 biolink:BiologicalProcess regulation of regulatory T cell differentiation Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. go.json regulation of regulatory T cell development|regulation of regulatory T lymphocyte differentiation|regulation of regulatory T-cell differentiation|regulation of regulatory T-lymphocyte differentiation|regulation of suppressor T cell differentiation|regulation of suppressor T lymphocyte differentiation|regulation of suppressor T-cell differentiation|regulation of suppressor T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045589 GO:0045587 biolink:BiologicalProcess negative regulation of gamma-delta T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation. go.json down regulation of gamma-delta T cell differentiation|down-regulation of gamma-delta T cell differentiation|downregulation of gamma-delta T cell differentiation|inhibition of gamma-delta T cell differentiation|negative regulation of gamma-delta T cell development|negative regulation of gamma-delta T lymphocyte differentiation|negative regulation of gamma-delta T-cell differentiation|negative regulation of gamma-delta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045587 GO:0045588 biolink:BiologicalProcess positive regulation of gamma-delta T cell differentiation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation. go.json activation of gamma-delta T cell differentiation|positive regulation of gamma-delta T cell development|positive regulation of gamma-delta T lymphocyte differentiation|positive regulation of gamma-delta T-cell differentiation|positive regulation of gamma-delta T-lymphocyte differentiation|stimulation of gamma-delta T cell differentiation|up regulation of gamma-delta T cell differentiation|up-regulation of gamma-delta T cell differentiation|upregulation of gamma-delta T cell differentiation http://purl.obolibrary.org/obo/GO_0045588 GO:0045585 biolink:BiologicalProcess positive regulation of cytotoxic T cell differentiation Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation. go.json activation of cytotoxic T cell differentiation|positive regulation of cytotoxic T cell development|positive regulation of cytotoxic T lymphocyte differentiation|positive regulation of cytotoxic T-cell differentiation|positive regulation of cytotoxic T-lymphocyte differentiation|stimulation of cytotoxic T cell differentiation|up regulation of cytotoxic T cell differentiation|up-regulation of cytotoxic T cell differentiation|upregulation of cytotoxic T cell differentiation http://purl.obolibrary.org/obo/GO_0045585 GO:0045586 biolink:BiologicalProcess regulation of gamma-delta T cell differentiation Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation. go.json regulation of gamma-delta T cell development|regulation of gamma-delta T lymphocyte differentiation|regulation of gamma-delta T-cell differentiation|regulation of gamma-delta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045586 GO:0045583 biolink:BiologicalProcess regulation of cytotoxic T cell differentiation Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation. go.json regulation of cytotoxic T cell development|regulation of cytotoxic T lymphocyte differentiation|regulation of cytotoxic T-cell differentiation|regulation of cytotoxic T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045583 GO:0045584 biolink:BiologicalProcess negative regulation of cytotoxic T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation. go.json down regulation of cytotoxic T cell differentiation|down-regulation of cytotoxic T cell differentiation|downregulation of cytotoxic T cell differentiation|inhibition of cytotoxic T cell differentiation|negative regulation of cytotoxic T cell development|negative regulation of cytotoxic T lymphocyte differentiation|negative regulation of cytotoxic T-cell differentiation|negative regulation of cytotoxic T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045584 GO:0070529 biolink:MolecularActivity L-tryptophan aminotransferase activity Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid. go.json http://purl.obolibrary.org/obo/GO_0070529 GO:0070527 biolink:BiologicalProcess platelet aggregation The adhesion of one platelet to one or more other platelets via adhesion molecules. go.json blood platelet aggregation|thrombocyte aggregation http://purl.obolibrary.org/obo/GO_0070527 GO:0070528 biolink:BiologicalProcess protein kinase C signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. go.json PKC signal transduction|PKC signaling cascade|protein kinase C signal transduction|protein kinase C signaling cascade|protein kinase C signalling cascade http://purl.obolibrary.org/obo/GO_0070528 GO:0070525 biolink:BiologicalProcess tRNA threonylcarbamoyladenosine metabolic process The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. go.json t6A metabolic process|t6A metabolism|threonylcarbamoyladenosine metabolism http://purl.obolibrary.org/obo/GO_0070525 GO:0070526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070526 GO:0070523 biolink:MolecularActivity 11-beta-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+. RHEA:53116|Wikipedia:11beta-hydroxysteroid_dehydrogenase go.json http://purl.obolibrary.org/obo/GO_0070523 GO:0070524 biolink:MolecularActivity 11-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+. EC:1.1.1.146|RHEA:11388|Reactome:R-HSA-9757706|Reactome:R-HSA-9759259|Wikipedia:11beta-hydroxysteroid_dehydrogenase go.json beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0070524 GO:0070521 biolink:CellularComponent alpha4-beta1 integrin-CD82 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family. go.json http://purl.obolibrary.org/obo/GO_0070521 GO:0070522 biolink:CellularComponent ERCC4-ERCC1 complex A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae. go.json Rad1-Rad10 complex|XPF-ERCC1 complex http://purl.obolibrary.org/obo/GO_0070522 GO:0070520 biolink:CellularComponent alpha4-beta1 integrin-CD81 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family. go.json ITGA4-ITGB1-CD81 complex http://purl.obolibrary.org/obo/GO_0070520 GO:0021592 biolink:BiologicalProcess fourth ventricle development The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space. go.json http://purl.obolibrary.org/obo/GO_0021592 GO:0021593 biolink:BiologicalProcess rhombomere morphogenesis The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. go.json http://purl.obolibrary.org/obo/GO_0021593 GO:0021594 biolink:BiologicalProcess rhombomere formation The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. go.json http://purl.obolibrary.org/obo/GO_0021594 GO:0021595 biolink:BiologicalProcess rhombomere structural organization The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. go.json rhombomere structural organisation http://purl.obolibrary.org/obo/GO_0021595 GO:0021597 biolink:BiologicalProcess central nervous system structural organization The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. go.json central nervous system structural organisation http://purl.obolibrary.org/obo/GO_0021597 GO:0021598 biolink:BiologicalProcess abducens nerve morphogenesis The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. go.json CN VI development http://purl.obolibrary.org/obo/GO_0021598 GO:0021599 biolink:BiologicalProcess abducens nerve formation The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. go.json CN VI biosynthesis|CN VI formation http://purl.obolibrary.org/obo/GO_0021599 GO:0021590 biolink:BiologicalProcess cerebellum maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. go.json http://purl.obolibrary.org/obo/GO_0021590 GO:0021591 biolink:BiologicalProcess ventricular system development The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. go.json http://purl.obolibrary.org/obo/GO_0021591 GO:0021581 biolink:BiologicalProcess medulla oblongata structural organization The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. go.json medulla oblongata structural organisation|medulla structural maturation|myelencephalon structural maturation http://purl.obolibrary.org/obo/GO_0021581 GO:0021582 biolink:BiologicalProcess medulla oblongata maturation A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. go.json medulla maturation|myelencephalon maturation http://purl.obolibrary.org/obo/GO_0021582 GO:0021583 biolink:BiologicalProcess pons morphogenesis The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. go.json http://purl.obolibrary.org/obo/GO_0021583 GO:0021584 biolink:BiologicalProcess pons formation The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. go.json http://purl.obolibrary.org/obo/GO_0021584 GO:0021585 biolink:BiologicalProcess pons structural organization The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. go.json pons structural organisation http://purl.obolibrary.org/obo/GO_0021585 GO:0021586 biolink:BiologicalProcess pons maturation A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. go.json http://purl.obolibrary.org/obo/GO_0021586 GO:0021587 biolink:BiologicalProcess cerebellum morphogenesis The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. go.json http://purl.obolibrary.org/obo/GO_0021587 GO:0021588 biolink:BiologicalProcess cerebellum formation The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. go.json http://purl.obolibrary.org/obo/GO_0021588 GO:0021580 biolink:BiologicalProcess medulla oblongata formation The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. go.json medulla biosynthesis|medulla formation|myelencephalon biosynthesis|myelencephalon formation http://purl.obolibrary.org/obo/GO_0021580 GO:0021589 biolink:BiologicalProcess cerebellum structural organization The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. go.json cerebellum structural organisation http://purl.obolibrary.org/obo/GO_0021589 GO:0021570 biolink:BiologicalProcess rhombomere 4 development The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021570 GO:0021571 biolink:BiologicalProcess rhombomere 5 development The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021571 GO:0021572 biolink:BiologicalProcess rhombomere 6 development The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021572 GO:0021573 biolink:BiologicalProcess rhombomere 7 development The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021573 GO:0021574 biolink:BiologicalProcess rhombomere 8 development The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021574 GO:0021575 biolink:BiologicalProcess hindbrain morphogenesis The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. go.json rhombencephalon morphogenesis http://purl.obolibrary.org/obo/GO_0021575 GO:0021576 biolink:BiologicalProcess hindbrain formation The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. go.json http://purl.obolibrary.org/obo/GO_0021576 GO:0021577 biolink:BiologicalProcess hindbrain structural organization The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. go.json hindbrain structural organisation http://purl.obolibrary.org/obo/GO_0021577 GO:0021578 biolink:BiologicalProcess hindbrain maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. go.json http://purl.obolibrary.org/obo/GO_0021578 GO:0021579 biolink:BiologicalProcess medulla oblongata morphogenesis The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. go.json medulla morphogenesis|myelencephalon morphogenesis http://purl.obolibrary.org/obo/GO_0021579 GO:0021560 biolink:BiologicalProcess abducens nerve development The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. go.json CN VI development|cranial nerve 6 development|cranial nerve VI development http://purl.obolibrary.org/obo/GO_0021560 GO:0021561 biolink:BiologicalProcess facial nerve development The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. go.json CN VII development|cranial nerve 7 development|cranial nerve VII development http://purl.obolibrary.org/obo/GO_0021561 GO:0021562 biolink:BiologicalProcess vestibulocochlear nerve development The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. go.json CN VIII development|acoustic nerve development|cranial nerve 8 development|cranial nerve VIII development http://purl.obolibrary.org/obo/GO_0021562 GO:0021563 biolink:BiologicalProcess glossopharyngeal nerve development Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. go.json CN IX development|cranial nerve 9 development|cranial nerve IX development http://purl.obolibrary.org/obo/GO_0021563 GO:0021564 biolink:BiologicalProcess vagus nerve development The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. go.json CN X development|cranial nerve 10 development|cranial nerve X development http://purl.obolibrary.org/obo/GO_0021564 GO:0021565 biolink:BiologicalProcess accessory nerve development The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. go.json CN XI development|cranial nerve 11 development|cranial nerve XI development|spinal accessory nerve development http://purl.obolibrary.org/obo/GO_0021565 GO:0021566 biolink:BiologicalProcess hypoglossal nerve development The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. go.json CN XII development|cranial nerve 12 development|cranial nerve XII development http://purl.obolibrary.org/obo/GO_0021566 GO:0021567 biolink:BiologicalProcess rhombomere 1 development The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021567 GO:0021568 biolink:BiologicalProcess rhombomere 2 development The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021568 GO:0021569 biolink:BiologicalProcess rhombomere 3 development The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021569 GO:0021550 biolink:BiologicalProcess medulla oblongata development The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. go.json medulla development|myelencephalon development http://purl.obolibrary.org/obo/GO_0021550 GO:0021551 biolink:BiologicalProcess central nervous system morphogenesis The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. go.json http://purl.obolibrary.org/obo/GO_0021551 GO:0021552 biolink:BiologicalProcess midbrain-hindbrain boundary structural organization The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. go.json MHB structural organization|isthmus structural organization|midbrain-hindbrain boundary structural organisation http://purl.obolibrary.org/obo/GO_0021552 GO:0021553 biolink:BiologicalProcess olfactory nerve development The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. go.json CN 1 development|cranial nerve 1 development|cranial nerve I development http://purl.obolibrary.org/obo/GO_0021553 GO:0021554 biolink:BiologicalProcess optic nerve development The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. go.json CN II development|cranial nerve 2 development|cranial nerve II development http://purl.obolibrary.org/obo/GO_0021554 GO:0021555 biolink:BiologicalProcess midbrain-hindbrain boundary morphogenesis The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. go.json MHB morphogenesis|isthmus morphogenesis http://purl.obolibrary.org/obo/GO_0021555 GO:0045501 biolink:BiologicalProcess regulation of sevenless signaling pathway Any process that modulates the frequency, rate or extent of the sevenless signaling pathway. go.json regulation of sev signaling pathway|regulation of sevenless signalling pathway http://purl.obolibrary.org/obo/GO_0045501 GO:0045502 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045502 GO:0045500 biolink:BiologicalProcess sevenless signaling pathway The series of molecular signals initiated by an extracellular ligand binding to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json sev receptor signaling pathway|sev signaling pathway|sevenless signalling pathway http://purl.obolibrary.org/obo/GO_0045500 GO:0045509 biolink:MolecularActivity interleukin-27 receptor activity Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-27 receptor activity|IL-27R http://purl.obolibrary.org/obo/GO_0045509 GO:0045507 biolink:MolecularActivity interleukin-25 receptor activity Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-25 receptor activity|IL-25R http://purl.obolibrary.org/obo/GO_0045507 GO:0045508 biolink:MolecularActivity interleukin-26 receptor activity Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-26 receptor activity|IL-26R http://purl.obolibrary.org/obo/GO_0045508 GO:0045505 biolink:MolecularActivity dynein intermediate chain binding Binding to an intermediate chain of the dynein complex. go.json http://purl.obolibrary.org/obo/GO_0045505 GO:0045506 biolink:MolecularActivity interleukin-24 receptor activity Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-24 receptor activity|IL-24R http://purl.obolibrary.org/obo/GO_0045506 GO:0045503 biolink:MolecularActivity dynein light chain binding Binding to a light chain of the dynein complex. go.json http://purl.obolibrary.org/obo/GO_0045503 GO:0045504 biolink:MolecularActivity dynein heavy chain binding Binding to a heavy chain of the dynein complex. go.json http://purl.obolibrary.org/obo/GO_0045504 GO:0021556 biolink:BiologicalProcess central nervous system formation The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. go.json http://purl.obolibrary.org/obo/GO_0021556 GO:0021557 biolink:BiologicalProcess oculomotor nerve development The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. go.json CN III development|cranial nerve 3 development|cranial nerve III development http://purl.obolibrary.org/obo/GO_0021557 GO:0021558 biolink:BiologicalProcess trochlear nerve development The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. go.json CN IV development|cranial nerve 4 development|cranial nerve IV development http://purl.obolibrary.org/obo/GO_0021558 GO:0021559 biolink:BiologicalProcess trigeminal nerve development The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. go.json CN V development|cranial nerve 5 development|cranial nerve V development http://purl.obolibrary.org/obo/GO_0021559 GO:0045471 biolink:BiologicalProcess response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. go.json http://purl.obolibrary.org/obo/GO_0045471 GO:0045472 biolink:BiologicalProcess response to ether Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. go.json http://purl.obolibrary.org/obo/GO_0045472 GO:0045470 biolink:BiologicalProcess R8 cell-mediated photoreceptor organization The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor. go.json R8-mediated photoreceptor organisation http://purl.obolibrary.org/obo/GO_0045470 GO:0045479 biolink:BiologicalProcess vesicle targeting to fusome The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome. go.json vesicle-fusome targeting http://purl.obolibrary.org/obo/GO_0045479 GO:0045477 biolink:BiologicalProcess regulation of nurse cell apoptotic process Any process that modulates the frequency, rate or extent of nurse cell apoptotic process. go.json regulation of nurse cell apoptosis http://purl.obolibrary.org/obo/GO_0045477 GO:0045478 biolink:BiologicalProcess fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells. go.json fusome organisation|fusome organization and biogenesis http://purl.obolibrary.org/obo/GO_0045478 goslim_pir GO:0045475 biolink:BiologicalProcess locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle. go.json circadian locomotor activity rhythm http://purl.obolibrary.org/obo/GO_0045475 GO:0045476 biolink:BiologicalProcess nurse cell apoptotic process Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process. go.json apoptosis of nurse cells|invertebrate nurse cell apoptosis|nurse cell apoptosis|nurse cell programmed cell death by apoptosis|programmed cell death of nurse cells by apoptosis http://purl.obolibrary.org/obo/GO_0045476 GO:0045473 biolink:BiologicalProcess obsolete response to ethanol (sensu Insecta) OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. go.json response to ethanol (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0045473 GO:0045474 biolink:BiologicalProcess obsolete response to ether (sensu Insecta) OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus. go.json response to ether (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0045474 GO:0070439 biolink:CellularComponent Mad-Max-mSin3A complex A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p. go.json http://purl.obolibrary.org/obo/GO_0070439 GO:0070437 biolink:CellularComponent Grb2-Shc complex A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway. go.json Grb2-Shc complex, EGF stimulated http://purl.obolibrary.org/obo/GO_0070437 GO:0070438 biolink:CellularComponent obsolete mTOR-FKBP12-rapamycin complex OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus). go.json Fkbp1a-Frap1 complex|mTOR-FKBP12-rapamycin complex True http://purl.obolibrary.org/obo/GO_0070438 GO:0070435 biolink:CellularComponent Shc-EGFR complex A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway. go.json Shc-Egfr complex, EGF stimulated http://purl.obolibrary.org/obo/GO_0070435 GO:0070436 biolink:CellularComponent Grb2-EGFR complex A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway. go.json Grb2-Egfr complex, EGF stimulated http://purl.obolibrary.org/obo/GO_0070436 GO:0070433 biolink:BiologicalProcess negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. go.json negative regulation of NOD2 signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway http://purl.obolibrary.org/obo/GO_0070433 GO:0070434 biolink:BiologicalProcess positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. go.json positive regulation of NOD2 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway http://purl.obolibrary.org/obo/GO_0070434 GO:0070431 biolink:BiologicalProcess nucleotide-binding oligomerization domain containing 2 signaling pathway The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process. go.json NOD2 signaling pathway|nucleotide-binding oligomerization domain containing 2 signalling pathway http://purl.obolibrary.org/obo/GO_0070431 GO:0070432 biolink:BiologicalProcess regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. go.json regulation of NOD2 signaling pathway|regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway http://purl.obolibrary.org/obo/GO_0070432 GO:0070430 biolink:BiologicalProcess positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway. go.json positive regulation of NOD1 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway http://purl.obolibrary.org/obo/GO_0070430 GO:0045482 biolink:MolecularActivity trichodiene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene. EC:4.2.3.6|KEGG_REACTION:R02306|MetaCyc:TRICHODIENE-SYNTHASE-RXN|RHEA:12052 go.json sesquiterpene cyclase activity|trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)|trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity|trichodiene synthetase activity http://purl.obolibrary.org/obo/GO_0045482 GO:0045483 biolink:MolecularActivity aristolochene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate. EC:4.2.3.9|MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN|RHEA:19825 go.json 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)|sesquiterpene cyclase activity|trans,trans-farnesyl diphosphate aristolochene-lyase activity|trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming) http://purl.obolibrary.org/obo/GO_0045483 GO:0045480 biolink:MolecularActivity galactose oxidase activity Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide. EC:1.1.3.9|MetaCyc:GALACTOSE-OXIDASE-RXN|RHEA:24160 go.json D-galactose oxidase activity|D-galactose:oxygen 6-oxidoreductase activity|beta-galactose oxidase activity http://purl.obolibrary.org/obo/GO_0045480 GO:0045481 biolink:MolecularActivity 6-endo-hydroxycineole dehydrogenase activity Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + H+ + NADH. EC:1.1.1.241|KEGG_REACTION:R02994|MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN|RHEA:11736 go.json 6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0045481 GO:0045488 biolink:BiologicalProcess pectin metabolic process The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge. go.json pectin metabolism http://purl.obolibrary.org/obo/GO_0045488 GO:0045489 biolink:BiologicalProcess pectin biosynthetic process The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. go.json pectin anabolism|pectin biosynthesis|pectin formation|pectin synthesis http://purl.obolibrary.org/obo/GO_0045489 GO:0045486 biolink:MolecularActivity naringenin 3-dioxygenase activity Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2. EC:1.14.11.9|MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN|RHEA:18621 go.json (2S)-flavanone 3-hydroxylase activity|flavanone 3-beta-hydroxylase activity|flavanone 3-dioxygenase activity|flavanone 3-hydroxylase activity|flavanone 3beta-hydroxylase activity|flavanone synthase I activity|flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|naringenin 3-hydroxylase activity|naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0045486 GO:0045487 biolink:BiologicalProcess gibberellin catabolic process The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. go.json gibberellic acid breakdown|gibberellic acid catabolic process|gibberellic acid catabolism|gibberellic acid degradation|gibberellin catabolism http://purl.obolibrary.org/obo/GO_0045487 GO:0045484 biolink:MolecularActivity L-lysine 6-transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine. EC:2.6.1.36|KEGG_REACTION:R00457|MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN|RHEA:21200 go.json L-lysine aminotransferase activity|L-lysine transaminase activity|L-lysine-alpha-ketoglutarate 6-aminotransferase activity|L-lysine-alpha-ketoglutarate aminotransferase activity|L-lysine:2-oxoglutarate 6-aminotransferase activity|lysine 6-aminotransferase activity|lysine epsilon-aminotransferase activity|lysine epsilon-transaminase activity|lysine:2-ketoglutarate 6-aminotransferase activity http://purl.obolibrary.org/obo/GO_0045484 GO:0045485 biolink:MolecularActivity omega-6 fatty acid desaturase activity Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain. Reactome:R-HSA-2046089|Reactome:R-HSA-2046092 go.json http://purl.obolibrary.org/obo/GO_0045485 GO:0070428 biolink:BiologicalProcess regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway. go.json regulation of NOD1 signaling pathway|regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway http://purl.obolibrary.org/obo/GO_0070428 GO:0070429 biolink:BiologicalProcess negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway. go.json negative regulation of NOD1 signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway http://purl.obolibrary.org/obo/GO_0070429 GO:0070426 biolink:BiologicalProcess positive regulation of nucleotide-binding oligomerization domain containing signaling pathway Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway. go.json positive regulation of NOD signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing signalling pathway http://purl.obolibrary.org/obo/GO_0070426 GO:0070427 biolink:BiologicalProcess nucleotide-binding oligomerization domain containing 1 signaling pathway The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process. go.json NOD1 signaling pathway|nucleotide-binding oligomerization domain containing 1 signalling pathway http://purl.obolibrary.org/obo/GO_0070427 GO:0070424 biolink:BiologicalProcess regulation of nucleotide-binding oligomerization domain containing signaling pathway Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway. go.json regulation of NOD signaling pathway|regulation of nucleotide-binding oligomerization domain containing signalling pathway http://purl.obolibrary.org/obo/GO_0070424 GO:0070425 biolink:BiologicalProcess negative regulation of nucleotide-binding oligomerization domain containing signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway. go.json negative regulation of NOD signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing signalling pathway http://purl.obolibrary.org/obo/GO_0070425 GO:0070422 biolink:CellularComponent G-protein beta/gamma-Raf-1 complex A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein. go.json G protein complex (GNG2, GNB2L1, RAF1) http://purl.obolibrary.org/obo/GO_0070422 GO:0070423 biolink:BiologicalProcess nucleotide-binding oligomerization domain containing signaling pathway The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing (NOD) protein receptor, and ending with regulation of a downstream cellular process. go.json NOD signaling pathway|nucleotide-binding oligomerization domain containing signalling pathway http://purl.obolibrary.org/obo/GO_0070423 GO:0070420 biolink:CellularComponent Ku-DNA ligase complex A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria. go.json http://purl.obolibrary.org/obo/GO_0070420 GO:0070421 biolink:CellularComponent DNA ligase III-XRCC1 complex A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair. go.json http://purl.obolibrary.org/obo/GO_0070421 GO:0045493 biolink:BiologicalProcess xylan catabolic process The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. go.json xylan breakdown|xylan catabolism|xylan degradation http://purl.obolibrary.org/obo/GO_0045493 GO:0070450 biolink:CellularComponent interleukin4-interleukin-4 receptor complex A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule. go.json IL4-IL4 receptor complex|IL4-IL4R-IL2RG complex http://purl.obolibrary.org/obo/GO_0070450 GO:0045494 biolink:BiologicalProcess photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. go.json http://purl.obolibrary.org/obo/GO_0045494 GO:0045491 biolink:BiologicalProcess xylan metabolic process The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone. go.json xylan metabolism http://purl.obolibrary.org/obo/GO_0045491 GO:0045492 biolink:BiologicalProcess xylan biosynthetic process The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. go.json xylan anabolism|xylan biosynthesis|xylan formation|xylan synthesis http://purl.obolibrary.org/obo/GO_0045492 GO:0045490 biolink:BiologicalProcess pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. go.json pectin breakdown|pectin catabolism|pectin degradation http://purl.obolibrary.org/obo/GO_0045490 GO:0045499 biolink:MolecularActivity chemorepellent activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. go.json chemorepellant activity http://purl.obolibrary.org/obo/GO_0045499 goslim_pir GO:0045497 biolink:BiologicalProcess female analia development The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0045497 GO:0045498 biolink:BiologicalProcess sex comb development The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg. go.json http://purl.obolibrary.org/obo/GO_0045498 GO:0045495 biolink:CellularComponent pole plasm Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. go.json germ plasm|polar plasm http://purl.obolibrary.org/obo/GO_0045495 GO:0045496 biolink:BiologicalProcess male analia development The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0045496 GO:0070459 biolink:BiologicalProcess prolactin secretion The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary. go.json http://purl.obolibrary.org/obo/GO_0070459 GO:0070457 biolink:MolecularActivity D-galactose-1-phosphate phosphatase activity Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate. go.json http://purl.obolibrary.org/obo/GO_0070457 GO:0070458 biolink:BiologicalProcess cellular detoxification of nitrogen compound Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. go.json cellular detoxification of nitrogenous compound http://purl.obolibrary.org/obo/GO_0070458 GO:0070455 biolink:BiologicalProcess positive regulation of heme biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme. go.json activation of heme biosynthetic process|positive regulation of haem biosynthetic process|positive regulation of heme anabolism|positive regulation of heme biosynthesis|positive regulation of heme formation|positive regulation of heme synthesis|stimulation of heme biosynthetic process|up regulation of heme biosynthetic process|up-regulation of heme biosynthetic process|upregulation of heme biosynthetic process http://purl.obolibrary.org/obo/GO_0070455 GO:0070456 biolink:MolecularActivity galactose-1-phosphate phosphatase activity Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate. go.json http://purl.obolibrary.org/obo/GO_0070456 GO:0070453 biolink:BiologicalProcess regulation of heme biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme. go.json regulation of haem biosynthesis|regulation of haem biosynthetic process|regulation of heme anabolism|regulation of heme biosynthesis|regulation of heme formation|regulation of heme synthesis http://purl.obolibrary.org/obo/GO_0070453 GO:0070454 biolink:BiologicalProcess negative regulation of heme biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme. go.json down regulation of heme biosynthetic process|down-regulation of heme biosynthetic process|downregulation of heme biosynthetic process|inhibition of heme biosynthetic process|negative regulation of haem biosynthetic process|negative regulation of heme anabolism|negative regulation of heme biosynthesis|negative regulation of heme formation|negative regulation of heme synthesis http://purl.obolibrary.org/obo/GO_0070454 GO:0070451 biolink:CellularComponent cell hair A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located. Wikipedia:Membrane_nanotube go.json imaginal disc-derived wing hair|non-sensory hair http://purl.obolibrary.org/obo/GO_0070451 GO:0070452 biolink:BiologicalProcess positive regulation of ergosterol biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. go.json activation of ergosterol biosynthetic process|positive regulation of ergosterol anabolism|positive regulation of ergosterol biosynthesis|positive regulation of ergosterol formation|positive regulation of ergosterol synthesis|stimulation of ergosterol biosynthetic process|up regulation of ergosterol biosynthetic process|up-regulation of ergosterol biosynthetic process|upregulation of ergosterol biosynthetic process http://purl.obolibrary.org/obo/GO_0070452 GO:0070448 biolink:MolecularActivity laricitrin 5'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin. EC:2.1.1.267|KEGG_REACTION:R06816|MetaCyc:RXN-8452|RHEA:25633 go.json CrCOMT2|S-adenosyl-L-methionine:myricetin O-methyltransferase activity|flavonoid 3',5'-O-dimethyltransferase activity http://purl.obolibrary.org/obo/GO_0070448 GO:0070449 biolink:CellularComponent elongin complex A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits. go.json elongin (SIII) complex|transcription elongation factor SIII complex|transcription factor B (SIII) complex http://purl.obolibrary.org/obo/GO_0070449 GO:0070446 biolink:BiologicalProcess negative regulation of oligodendrocyte progenitor proliferation Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation. go.json negative regulation of oligodendrocyte precursor proliferation http://purl.obolibrary.org/obo/GO_0070446 GO:0070447 biolink:BiologicalProcess positive regulation of oligodendrocyte progenitor proliferation Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation. go.json positive regulation of oligodendrocyte precursor proliferation http://purl.obolibrary.org/obo/GO_0070447 GO:0070444 biolink:BiologicalProcess oligodendrocyte progenitor proliferation The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system. go.json oligodendrocyte precursor proliferation http://purl.obolibrary.org/obo/GO_0070444 GO:0070445 biolink:BiologicalProcess regulation of oligodendrocyte progenitor proliferation Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation. go.json regulation of oligodendrocyte precursor proliferation http://purl.obolibrary.org/obo/GO_0070445 GO:0070442 biolink:CellularComponent integrin alphaIIb-beta3 complex An integrin complex that comprises one alphaIIb subunit and one beta3 subunit. go.json ITGA2B-ITGB3 complex|alphaIIb-beta3 integrin complex http://purl.obolibrary.org/obo/GO_0070442 GO:0070443 biolink:CellularComponent Mad-Max complex A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max. go.json http://purl.obolibrary.org/obo/GO_0070443 GO:0070440 biolink:CellularComponent Mad-Max-mSin3B complex A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p. go.json http://purl.obolibrary.org/obo/GO_0070440 GO:0070441 biolink:CellularComponent G-protein beta/gamma-Btk complex A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein. go.json G protein complex (BTK, GNG1, GNG2)|G protein complex (Btk, Gng2, Gnb1) http://purl.obolibrary.org/obo/GO_0070441 GO:0070471 biolink:BiologicalProcess uterine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth. go.json myometrial contraction|myometrial smooth muscle contraction|myometrium contraction http://purl.obolibrary.org/obo/GO_0070471 GO:0070472 biolink:BiologicalProcess regulation of uterine smooth muscle contraction Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction. go.json regulation of myometrial contraction|regulation of myometrial smooth muscle contraction|regulation of myometrium contraction http://purl.obolibrary.org/obo/GO_0070472 GO:0070470 biolink:CellularComponent plasma membrane respirasome A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. go.json plasma membrane electron transport chain|plasma membrane respiratory chain http://purl.obolibrary.org/obo/GO_0070470 GO:0070479 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. go.json 5'-3' NMD|5'-3' nonsense-mediated decay|5'-3' nonsense-mediated mRNA decay|nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay http://purl.obolibrary.org/obo/GO_0070479 GO:0070477 biolink:CellularComponent endospore core An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive. go.json http://purl.obolibrary.org/obo/GO_0070477 GO:0070478 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. go.json 3'-5' NMD|3'-5' nonsense-mediated decay|3'-5' nonsense-mediated mRNA decay|nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay http://purl.obolibrary.org/obo/GO_0070478 GO:0070475 biolink:BiologicalProcess rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070475 GO:0070476 biolink:BiologicalProcess rRNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0070476 GO:0070473 biolink:BiologicalProcess negative regulation of uterine smooth muscle contraction Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction. go.json down regulation of uterine smooth muscle contraction|down-regulation of uterine smooth muscle contraction|downregulation of uterine smooth muscle contraction|inhibition of uterine smooth muscle contraction|negative regulation of myometrial contraction|negative regulation of myometrial smooth muscle contraction|negative regulation of myometrium contraction|uterine smooth muscle relaxation http://purl.obolibrary.org/obo/GO_0070473 GO:0070474 biolink:BiologicalProcess positive regulation of uterine smooth muscle contraction Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. go.json activation of uterine smooth muscle contraction|positive regulation of myometrial contraction|positive regulation of myometrial smooth muscle contraction|positive regulation of myometrium contraction|stimulation of uterine smooth muscle contraction|up regulation of uterine smooth muscle contraction|up-regulation of uterine smooth muscle contraction|upregulation of uterine smooth muscle contraction http://purl.obolibrary.org/obo/GO_0070474 GO:0070460 biolink:BiologicalProcess thyroid-stimulating hormone secretion The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary. go.json TSH secretion|thyroid stimulating hormone secretion http://purl.obolibrary.org/obo/GO_0070460 GO:0070461 biolink:CellularComponent SAGA-type complex A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs). go.json SAGA family complex http://purl.obolibrary.org/obo/GO_0070461 GO:0070468 biolink:BiologicalProcess dentin extracellular matrix secretion The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin. go.json dentin secretion|dentine secretion|predentin secretion http://purl.obolibrary.org/obo/GO_0070468 GO:0070469 biolink:CellularComponent respirasome The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. go.json membrane electron transport chain|respiratory chain http://purl.obolibrary.org/obo/GO_0070469 GO:0070466 biolink:CellularComponent alpha2-beta1 integrin-alpha3(VI) complex A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain. go.json ITGA2-ITGB1-COL6A3 complex http://purl.obolibrary.org/obo/GO_0070466 GO:0070467 biolink:CellularComponent RC-1 DNA recombination complex A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA. go.json DNA recombination complex RC-1|RC-1 complex (recombination complex 1) http://purl.obolibrary.org/obo/GO_0070467 GO:0070464 biolink:CellularComponent alphav-beta3 integrin-collagen alpha3(VI) complex A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen. go.json http://purl.obolibrary.org/obo/GO_0070464 GO:0070465 biolink:CellularComponent alpha1-beta1 integrin-alpha3(VI) complex A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain. go.json ITGA1-ITGB1-COL6A3 complex http://purl.obolibrary.org/obo/GO_0070465 GO:0070462 biolink:BiologicalProcess plus-end specific microtubule depolymerization The removal of tubulin heterodimers from the plus end of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0070462 GO:0070463 biolink:MolecularActivity tubulin-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate. go.json tubulin-activated ATPase activity http://purl.obolibrary.org/obo/GO_0070463 GO:0070493 biolink:BiologicalProcess thrombin-activated receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json thrombin receptor signaling pathway|thrombin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070493 GO:0070494 biolink:BiologicalProcess regulation of thrombin-activated receptor signaling pathway Any process that modulates the frequency, rate or extent of a thrombin-activated receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. go.json regulation of thrombin receptor signaling pathway|regulation of thrombin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070494 GO:0070491 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070491 GO:0070492 biolink:MolecularActivity oligosaccharide binding Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. go.json http://purl.obolibrary.org/obo/GO_0070492 GO:0070490 biolink:BiologicalProcess protein pupylation The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein. go.json Pup-protein conjugation|pupylation http://purl.obolibrary.org/obo/GO_0070490 GO:0070499 biolink:BiologicalProcess exosporium assembly A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore. go.json exosporium formation http://purl.obolibrary.org/obo/GO_0070499 GO:0070497 biolink:MolecularActivity 6-carboxy-5,6,7,8-tetrahydropterin synthase activity Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. EC:4.1.2.50|MetaCyc:RXN0-5507|RHEA:27966 go.json http://purl.obolibrary.org/obo/GO_0070497 GO:0070498 biolink:BiologicalProcess interleukin-1-mediated signaling pathway The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-1 alpha-mediated signaling pathway|IL-1 beta-mediated signaling pathway|IL-1-mediated signaling pathway|interleukin-1 alpha-mediated signaling pathway|interleukin-1 beta-mediated signaling pathway|interleukin-1-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0070498 GO:0070495 biolink:BiologicalProcess negative regulation of thrombin-activated receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. go.json negative regulation of thrombin receptor signaling pathway|negative regulation of thrombin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070495 GO:0070496 biolink:BiologicalProcess positive regulation of thrombin-activated receptor signaling pathway Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. go.json positive regulation of thrombin receptor signaling pathway|positive regulation of thrombin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070496 GO:0070482 biolink:BiologicalProcess response to oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. go.json http://purl.obolibrary.org/obo/GO_0070482 GO:0070483 biolink:BiologicalProcess detection of hypoxia The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. go.json detection of reduced oxygen levels http://purl.obolibrary.org/obo/GO_0070483 GO:0070480 biolink:BiologicalProcess exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay. go.json exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay|exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay|exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay http://purl.obolibrary.org/obo/GO_0070480 GO:0070481 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, non-stop decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon. go.json non-stop decay|non-stop mRNA decay|nonstop mRNA decay|nuclear-transcribed mRNA breakdown, non-stop decay|nuclear-transcribed mRNA catabolism, non-stop decay|nuclear-transcribed mRNA degradation, non-stop decay http://purl.obolibrary.org/obo/GO_0070481 GO:0070488 biolink:BiologicalProcess neutrophil aggregation The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules. go.json neutrocyte aggregation|neutrophil leucocyte aggregation|neutrophil leukocyte aggregation|neutrophilic leucocyte aggregation|neutrophilic leukocyte aggregation http://purl.obolibrary.org/obo/GO_0070488 GO:0070489 biolink:BiologicalProcess T cell aggregation The adhesion of one T cell to one or more other T cells via adhesion molecules. go.json T lymphocyte aggregation|T-cell aggregation|T-lymphocyte aggregation http://purl.obolibrary.org/obo/GO_0070489 GO:0070486 biolink:BiologicalProcess leukocyte aggregation The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules. go.json immune cell aggregation|leucocyte aggregation|white blood cell aggregation|white corpuscle aggregation http://purl.obolibrary.org/obo/GO_0070486 GO:0070487 biolink:BiologicalProcess monocyte aggregation The adhesion of one monocyte to one or more other monocytes via adhesion molecules. go.json mononuclear phagocyte aggregation http://purl.obolibrary.org/obo/GO_0070487 GO:0070484 biolink:BiologicalProcess dehydro-D-arabinono-1,4-lactone metabolic process The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one. go.json dehydro-D-arabinono-1,4-lactone metabolism http://purl.obolibrary.org/obo/GO_0070484 GO:0070485 biolink:BiologicalProcess dehydro-D-arabinono-1,4-lactone biosynthetic process The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one. go.json dehydro-D-arabinono-1,4-lactone anabolism|dehydro-D-arabinono-1,4-lactone biosynthesis|dehydro-D-arabinono-1,4-lactone formation|dehydro-D-arabinono-1,4-lactone synthesis http://purl.obolibrary.org/obo/GO_0070485 GO:0021660 biolink:BiologicalProcess rhombomere 3 formation The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021660 GO:0021661 biolink:BiologicalProcess rhombomere 4 morphogenesis The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021661 GO:0021662 biolink:BiologicalProcess rhombomere 4 structural organization The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 4 structural organisation http://purl.obolibrary.org/obo/GO_0021662 GO:0006029 biolink:BiologicalProcess proteoglycan metabolic process The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. go.json proteoglycan metabolism|proteoglycan sulfate transfer http://purl.obolibrary.org/obo/GO_0006029 GO:0021663 biolink:BiologicalProcess rhombomere 4 formation The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021663 GO:0021664 biolink:BiologicalProcess rhombomere 5 morphogenesis The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021664 GO:0006027 biolink:BiologicalProcess glycosaminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. go.json glycosaminoglycan breakdown|glycosaminoglycan catabolism|glycosaminoglycan degradation http://purl.obolibrary.org/obo/GO_0006027 GO:0021665 biolink:BiologicalProcess rhombomere 5 structural organization The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 5 structural organisation http://purl.obolibrary.org/obo/GO_0021665 GO:0006028 biolink:BiologicalProcess galactosaminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose. go.json galactosaminoglycan breakdown|galactosaminoglycan catabolism|galactosaminoglycan degradation http://purl.obolibrary.org/obo/GO_0006028 GO:0006025 biolink:BiologicalProcess galactosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose. go.json galactosaminoglycan anabolism|galactosaminoglycan biosynthesis|galactosaminoglycan formation|galactosaminoglycan synthesis http://purl.obolibrary.org/obo/GO_0006025 GO:0045633 biolink:BiologicalProcess positive regulation of mechanoreceptor differentiation Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation. go.json activation of mechanoreceptor differentiation|stimulation of mechanoreceptor differentiation|up regulation of mechanoreceptor differentiation|up-regulation of mechanoreceptor differentiation|upregulation of mechanoreceptor differentiation http://purl.obolibrary.org/obo/GO_0045633 GO:0045634 biolink:BiologicalProcess regulation of melanocyte differentiation Any process that modulates the frequency, rate or extent of melanocyte differentiation. go.json regulation of melanophore differentiation http://purl.obolibrary.org/obo/GO_0045634 GO:0006026 biolink:BiologicalProcess aminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. go.json aminoglycan breakdown|aminoglycan catabolism|aminoglycan degradation http://purl.obolibrary.org/obo/GO_0006026 GO:0045631 biolink:BiologicalProcess regulation of mechanoreceptor differentiation Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation. go.json http://purl.obolibrary.org/obo/GO_0045631 GO:0006023 biolink:BiologicalProcess aminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. go.json aminoglycan anabolism|aminoglycan biosynthesis|aminoglycan formation|aminoglycan synthesis http://purl.obolibrary.org/obo/GO_0006023 GO:0045632 biolink:BiologicalProcess negative regulation of mechanoreceptor differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation. go.json down regulation of mechanoreceptor differentiation|down-regulation of mechanoreceptor differentiation|downregulation of mechanoreceptor differentiation|inhibition of mechanoreceptor differentiation http://purl.obolibrary.org/obo/GO_0045632 GO:0006024 biolink:BiologicalProcess glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. go.json glycosaminoglycan anabolism|glycosaminoglycan biosynthesis|glycosaminoglycan formation|glycosaminoglycan synthesis http://purl.obolibrary.org/obo/GO_0006024 GO:0006021 biolink:BiologicalProcess inositol biosynthetic process The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. go.json inositol anabolism|inositol biosynthesis|inositol formation|inositol synthesis|myo-inositol biosynthesis|myo-inositol biosynthetic process|vitamin Bh biosynthesis|vitamin Bh biosynthetic process http://purl.obolibrary.org/obo/GO_0006021 GO:0045630 biolink:BiologicalProcess positive regulation of T-helper 2 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation. go.json activation of T-helper 2 cell differentiation|positive regulation of T-helper 2 cell development|stimulation of T-helper 2 cell differentiation|up regulation of T-helper 2 cell differentiation|up-regulation of T-helper 2 cell differentiation|upregulation of T-helper 2 cell differentiation http://purl.obolibrary.org/obo/GO_0045630 GO:0006022 biolink:BiologicalProcess aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. go.json aminoglycan metabolism http://purl.obolibrary.org/obo/GO_0006022 GO:0006020 biolink:BiologicalProcess inositol metabolic process The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. Wikipedia:Inositol go.json inositol metabolism|myo-inositol metabolic process|myo-inositol metabolism|vitamin Bh metabolic process|vitamin Bh metabolism http://purl.obolibrary.org/obo/GO_0006020 GO:0045639 biolink:BiologicalProcess positive regulation of myeloid cell differentiation Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. go.json activation of myeloid cell differentiation|stimulation of myeloid cell differentiation|up regulation of myeloid cell differentiation|up-regulation of myeloid cell differentiation|upregulation of myeloid cell differentiation http://purl.obolibrary.org/obo/GO_0045639 GO:0045637 biolink:BiologicalProcess regulation of myeloid cell differentiation Any process that modulates the frequency, rate or extent of myeloid cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0045637 GO:0045638 biolink:BiologicalProcess negative regulation of myeloid cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. go.json down regulation of myeloid cell differentiation|down-regulation of myeloid cell differentiation|downregulation of myeloid cell differentiation|inhibition of myeloid cell differentiation http://purl.obolibrary.org/obo/GO_0045638 GO:0045635 biolink:BiologicalProcess negative regulation of melanocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation. go.json down regulation of melanocyte differentiation|down-regulation of melanocyte differentiation|downregulation of melanocyte differentiation|inhibition of melanocyte differentiation|negative regulation of melanophore differentiation http://purl.obolibrary.org/obo/GO_0045635 GO:0045636 biolink:BiologicalProcess positive regulation of melanocyte differentiation Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. go.json activation of melanocyte differentiation|positive regulation of melanophore differentiation|stimulation of melanocyte differentiation|up regulation of melanocyte differentiation|up-regulation of melanocyte differentiation|upregulation of melanocyte differentiation http://purl.obolibrary.org/obo/GO_0045636 GO:0021666 biolink:BiologicalProcess rhombomere 5 formation The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021666 GO:0021667 biolink:BiologicalProcess rhombomere 6 morphogenesis The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021667 GO:0021668 biolink:BiologicalProcess rhombomere 6 structural organization The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 6 structural organisation http://purl.obolibrary.org/obo/GO_0021668 GO:0021669 biolink:BiologicalProcess rhombomere 6 formation The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021669 GO:0021650 biolink:BiologicalProcess vestibulocochlear nerve formation The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. go.json CN VII formation http://purl.obolibrary.org/obo/GO_0021650 GO:0021651 biolink:BiologicalProcess rhombomere 1 morphogenesis The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021651 GO:0021652 biolink:BiologicalProcess rhombomere 1 formation The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021652 GO:0021653 biolink:BiologicalProcess rhombomere 1 structural organization The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 1 structural organisation http://purl.obolibrary.org/obo/GO_0021653 GO:0006038 biolink:BiologicalProcess cell wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. go.json cell wall chitin anabolism|cell wall chitin biosynthesis|cell wall chitin formation|cell wall chitin synthesis http://purl.obolibrary.org/obo/GO_0006038 GO:0006039 biolink:BiologicalProcess cell wall chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. go.json cell wall chitin breakdown|cell wall chitin catabolism|cell wall chitin degradation http://purl.obolibrary.org/obo/GO_0006039 GO:0021654 biolink:BiologicalProcess rhombomere boundary formation The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021654 GO:0045644 biolink:BiologicalProcess negative regulation of eosinophil differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation. go.json down regulation of eosinophil differentiation|down-regulation of eosinophil differentiation|downregulation of eosinophil differentiation|inhibition of eosinophil differentiation http://purl.obolibrary.org/obo/GO_0045644 GO:0006036 biolink:BiologicalProcess cuticle chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. go.json cuticle chitin breakdown|cuticle chitin catabolism|cuticle chitin degradation http://purl.obolibrary.org/obo/GO_0006036 GO:0045645 biolink:BiologicalProcess positive regulation of eosinophil differentiation Any process that activates or increases the frequency, rate or extent of eosinophil differentiation. go.json activation of eosinophil differentiation|stimulation of eosinophil differentiation|up regulation of eosinophil differentiation|up-regulation of eosinophil differentiation|upregulation of eosinophil differentiation http://purl.obolibrary.org/obo/GO_0045645 GO:0006037 biolink:BiologicalProcess cell wall chitin metabolic process The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. go.json cell wall chitin metabolism http://purl.obolibrary.org/obo/GO_0006037 GO:0045642 biolink:BiologicalProcess positive regulation of basophil differentiation Any process that activates or increases the frequency, rate or extent of basophil differentiation. go.json activation of basophil differentiation|stimulation of basophil differentiation|up regulation of basophil differentiation|up-regulation of basophil differentiation|upregulation of basophil differentiation http://purl.obolibrary.org/obo/GO_0045642 GO:0006034 biolink:BiologicalProcess cuticle chitin metabolic process The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. go.json cuticle chitin metabolism http://purl.obolibrary.org/obo/GO_0006034 GO:0006035 biolink:BiologicalProcess cuticle chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. go.json cuticle chitin anabolism|cuticle chitin biosynthesis|cuticle chitin formation|cuticle chitin synthesis http://purl.obolibrary.org/obo/GO_0006035 GO:0045643 biolink:BiologicalProcess regulation of eosinophil differentiation Any process that modulates the frequency, rate or extent of eosinophil differentiation. go.json http://purl.obolibrary.org/obo/GO_0045643 GO:0006032 biolink:BiologicalProcess chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. go.json beta-1,4-linked N-acetylglucosamine catabolic process|beta-1,4-linked N-acetylglucosamine catabolism|chitin breakdown|chitin catabolism|chitin degradation http://purl.obolibrary.org/obo/GO_0006032 GO:0045640 biolink:BiologicalProcess regulation of basophil differentiation Any process that modulates the frequency, rate or extent of basophil differentiation. go.json http://purl.obolibrary.org/obo/GO_0045640 GO:0045641 biolink:BiologicalProcess negative regulation of basophil differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation. go.json down regulation of basophil differentiation|down-regulation of basophil differentiation|downregulation of basophil differentiation|inhibition of basophil differentiation http://purl.obolibrary.org/obo/GO_0045641 GO:0006033 biolink:BiologicalProcess chitin localization A process in which chitin is transported to, or maintained in, a specific location. go.json chitin localisation|establishment and maintenance of chitin localization http://purl.obolibrary.org/obo/GO_0006033 GO:0006030 biolink:BiologicalProcess chitin metabolic process The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. go.json beta-1,4-linked N-acetylglucosamine metabolic process|beta-1,4-linked N-acetylglucosamine metabolism|chitin metabolism http://purl.obolibrary.org/obo/GO_0006030 GO:0006031 biolink:BiologicalProcess chitin biosynthetic process The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. go.json beta-1,4-linked N-acetylglucosamine biosynthesis|beta-1,4-linked N-acetylglucosamine biosynthetic process|chitin anabolism|chitin biosynthesis|chitin formation|chitin synthesis http://purl.obolibrary.org/obo/GO_0006031 GO:0006040 biolink:BiologicalProcess amino sugar metabolic process The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. go.json amino sugar metabolism|aminosaccharide metabolic process|aminosaccharide metabolism http://purl.obolibrary.org/obo/GO_0006040 GO:0045648 biolink:BiologicalProcess positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. go.json activation of erythrocyte differentiation|positive regulation of RBC differentiation|positive regulation of red blood cell differentiation|stimulation of erythrocyte differentiation|up regulation of erythrocyte differentiation|up-regulation of erythrocyte differentiation|upregulation of erythrocyte differentiation http://purl.obolibrary.org/obo/GO_0045648 GO:0045649 biolink:BiologicalProcess regulation of macrophage differentiation Any process that modulates the frequency, rate or extent of macrophage differentiation. go.json http://purl.obolibrary.org/obo/GO_0045649 GO:0045646 biolink:BiologicalProcess regulation of erythrocyte differentiation Any process that modulates the frequency, rate or extent of erythrocyte differentiation. go.json regulation of RBC differentiation|regulation of red blood cell differentiation http://purl.obolibrary.org/obo/GO_0045646 GO:0045647 biolink:BiologicalProcess negative regulation of erythrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. go.json down regulation of erythrocyte differentiation|down-regulation of erythrocyte differentiation|downregulation of erythrocyte differentiation|inhibition of erythrocyte differentiation|negative regulation of RBC differentiation|negative regulation of red blood cell differentiation http://purl.obolibrary.org/obo/GO_0045647 GO:0021655 biolink:BiologicalProcess rhombomere 2 morphogenesis The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021655 GO:0021656 biolink:BiologicalProcess rhombomere 2 structural organization The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 2 structural organisation http://purl.obolibrary.org/obo/GO_0021656 GO:0021657 biolink:BiologicalProcess rhombomere 2 formation The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021657 GO:0021658 biolink:BiologicalProcess rhombomere 3 morphogenesis The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021658 GO:0021659 biolink:BiologicalProcess rhombomere 3 structural organization The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 3 structural organisation http://purl.obolibrary.org/obo/GO_0021659 GO:0006009 biolink:BiologicalProcess glucose 1-phosphate phosphorylation The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate. go.json http://purl.obolibrary.org/obo/GO_0006009 GO:0021640 biolink:BiologicalProcess trochlear nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. go.json CN IV maturation http://purl.obolibrary.org/obo/GO_0021640 GO:0006007 biolink:BiologicalProcess glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. go.json glucose breakdown|glucose catabolism|glucose degradation http://purl.obolibrary.org/obo/GO_0006007 GO:0021641 biolink:BiologicalProcess trochlear nerve structural organization The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. go.json CN IV structural organization|trochlear nerve structural organisation http://purl.obolibrary.org/obo/GO_0021641 GO:0006008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006008 GO:0021642 biolink:BiologicalProcess trochlear nerve formation The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. go.json CN IV biosynthesis|CN IV formation http://purl.obolibrary.org/obo/GO_0021642 GO:0006005 biolink:BiologicalProcess L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose). go.json L-fucose anabolism|L-fucose biosynthesis|L-fucose formation|L-fucose synthesis http://purl.obolibrary.org/obo/GO_0006005 GO:0006006 biolink:BiologicalProcess glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. go.json cellular glucose metabolic process|glucose metabolism http://purl.obolibrary.org/obo/GO_0006006 GO:0021643 biolink:BiologicalProcess vagus nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. go.json CN X maturation http://purl.obolibrary.org/obo/GO_0021643 GO:0045655 biolink:BiologicalProcess regulation of monocyte differentiation Any process that modulates the frequency, rate or extent of monocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0045655 GO:0006003 biolink:BiologicalProcess fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. go.json fructose 2,6-bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0006003 GO:0045656 biolink:BiologicalProcess negative regulation of monocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. go.json down regulation of monocyte differentiation|down-regulation of monocyte differentiation|downregulation of monocyte differentiation|inhibition of monocyte differentiation http://purl.obolibrary.org/obo/GO_0045656 GO:0006004 biolink:BiologicalProcess fucose metabolic process The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. go.json fucose metabolism http://purl.obolibrary.org/obo/GO_0006004 GO:0045653 biolink:BiologicalProcess negative regulation of megakaryocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. go.json down regulation of megakaryocyte differentiation|down-regulation of megakaryocyte differentiation|downregulation of megakaryocyte differentiation|inhibition of megakaryocyte differentiation http://purl.obolibrary.org/obo/GO_0045653 GO:0006001 biolink:BiologicalProcess fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose. go.json fructose breakdown|fructose catabolism|fructose degradation http://purl.obolibrary.org/obo/GO_0006001 GO:0045654 biolink:BiologicalProcess positive regulation of megakaryocyte differentiation Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. go.json activation of megakaryocyte differentiation|stimulation of megakaryocyte differentiation|up regulation of megakaryocyte differentiation|up-regulation of megakaryocyte differentiation|upregulation of megakaryocyte differentiation http://purl.obolibrary.org/obo/GO_0045654 GO:0006002 biolink:BiologicalProcess fructose 6-phosphate metabolic process The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. go.json fructose 6-phosphate metabolism http://purl.obolibrary.org/obo/GO_0006002 GO:0045651 biolink:BiologicalProcess positive regulation of macrophage differentiation Any process that activates or increases the frequency, rate or extent of macrophage differentiation. go.json activation of macrophage differentiation|stimulation of macrophage differentiation|up regulation of macrophage differentiation|up-regulation of macrophage differentiation|upregulation of macrophage differentiation http://purl.obolibrary.org/obo/GO_0045651 GO:0045652 biolink:BiologicalProcess regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0045652 GO:0006000 biolink:BiologicalProcess fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. Wikipedia:Fructose go.json fructose metabolism http://purl.obolibrary.org/obo/GO_0006000 GO:0045650 biolink:BiologicalProcess negative regulation of macrophage differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. go.json down regulation of macrophage differentiation|down-regulation of macrophage differentiation|downregulation of macrophage differentiation|inhibition of macrophage differentiation http://purl.obolibrary.org/obo/GO_0045650 GO:0070619 biolink:CellularComponent Shc-Grb2-Sos complex A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. go.json Shc-Grb2-mSos1 complex, EGF stimulated http://purl.obolibrary.org/obo/GO_0070619 GO:0070617 biolink:BiologicalProcess negative regulation of thiamine diphosphate biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate. go.json down regulation of thiamine diphosphate biosynthetic process|down-regulation of thiamine diphosphate biosynthetic process|downregulation of thiamine diphosphate biosynthetic process|inhibition of thiamine diphosphate biosynthetic process|negative regulation of thiamin diphosphate biosynthetic process|negative regulation of thiamine diphosphate anabolism|negative regulation of thiamine diphosphate biosynthesis|negative regulation of thiamine diphosphate formation|negative regulation of thiamine diphosphate synthesis http://purl.obolibrary.org/obo/GO_0070617 GO:0070618 biolink:CellularComponent Grb2-Sos complex A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. go.json Grb2-mSos1 complex http://purl.obolibrary.org/obo/GO_0070618 GO:0045659 biolink:BiologicalProcess negative regulation of neutrophil differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation. go.json down regulation of neutrophil differentiation|down-regulation of neutrophil differentiation|downregulation of neutrophil differentiation|inhibition of neutrophil differentiation http://purl.obolibrary.org/obo/GO_0045659 GO:0070615 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070615 GO:0070616 biolink:BiologicalProcess regulation of thiamine diphosphate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate. go.json regulation of thiamin diphosphate biosynthetic process|regulation of thiamine diphosphate anabolism|regulation of thiamine diphosphate biosynthesis|regulation of thiamine diphosphate formation|regulation of thiamine diphosphate synthesis http://purl.obolibrary.org/obo/GO_0070616 GO:0045657 biolink:BiologicalProcess positive regulation of monocyte differentiation Any process that activates or increases the frequency, rate or extent of monocyte differentiation. go.json activation of monocyte differentiation|stimulation of monocyte differentiation|up regulation of monocyte differentiation|up-regulation of monocyte differentiation|upregulation of monocyte differentiation http://purl.obolibrary.org/obo/GO_0045657 GO:0070613 biolink:BiologicalProcess regulation of protein processing Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. go.json regulation of protein maturation by peptide bond cleavage http://purl.obolibrary.org/obo/GO_0070613 GO:0045658 biolink:BiologicalProcess regulation of neutrophil differentiation Any process that modulates the frequency, rate or extent of neutrophil differentiation. go.json http://purl.obolibrary.org/obo/GO_0045658 GO:0070614 biolink:BiologicalProcess tungstate ion transport The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten. go.json http://purl.obolibrary.org/obo/GO_0070614 GO:0070611 biolink:MolecularActivity histone H3R2 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3. go.json histone H3R2 arginine methyltransferase activity|histone methylase activity (H3-R2 specific)|histone methyltransferase activity (H3-R2 specific)|histone-H3R2 methyltransferase activity|histone-arginine N-methyltransferase activity (H3-R2 specific) http://purl.obolibrary.org/obo/GO_0070611 GO:0021644 biolink:BiologicalProcess vagus nerve morphogenesis The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. go.json CN X morphogenesis http://purl.obolibrary.org/obo/GO_0021644 GO:0070612 biolink:MolecularActivity histone H2AR3 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A. go.json histone H2AR3 arginine methyltransferase activity|histone methylase activity (H2A-R3 specific)|histone methyltransferase activity (H2A-R3 specific)|histone-H2AR3 methyltransferase activity|histone-arginine N-methyltransferase activity (H2A-R3 specific) http://purl.obolibrary.org/obo/GO_0070612 GO:0021645 biolink:BiologicalProcess vagus nerve structural organization The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. go.json CN X structural organization|vagus nerve structural organisation http://purl.obolibrary.org/obo/GO_0021645 GO:0021646 biolink:BiologicalProcess vagus nerve formation The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. go.json CN X biosynthesis|CN X formation http://purl.obolibrary.org/obo/GO_0021646 GO:0070610 biolink:BiologicalProcess regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores. go.json regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process|regulation of fungal-type cell wall 1,3-alpha-glucan anabolism|regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis|regulation of fungal-type cell wall 1,3-alpha-glucan formation|regulation of fungal-type cell wall 1,3-alpha-glucan synthesis|regulation of fungal-type cell wall alpha-1,3-glucan anabolism|regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis|regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process|regulation of fungal-type cell wall alpha-1,3-glucan formation|regulation of fungal-type cell wall alpha-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0070610 GO:0021647 biolink:BiologicalProcess vestibulocochlear nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. go.json CN VIII maturation|auditory nerve maturation http://purl.obolibrary.org/obo/GO_0021647 GO:0021648 biolink:BiologicalProcess vestibulocochlear nerve morphogenesis The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. go.json CN VIII morphogenesis http://purl.obolibrary.org/obo/GO_0021648 GO:0021649 biolink:BiologicalProcess vestibulocochlear nerve structural organization The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. go.json CN VII structural organization|vestibulocochlear nerve structural organisation http://purl.obolibrary.org/obo/GO_0021649 GO:0006018 biolink:BiologicalProcess 2-deoxyribose 1-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. go.json 2-deoxyribose 1-phosphate breakdown|2-deoxyribose 1-phosphate catabolism|2-deoxyribose 1-phosphate degradation|deoxyribose 1-phosphate catabolic process http://purl.obolibrary.org/obo/GO_0006018 GO:0021630 biolink:BiologicalProcess olfactory nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. go.json CN I maturation http://purl.obolibrary.org/obo/GO_0021630 GO:0006019 biolink:BiologicalProcess deoxyribose 5-phosphate phosphorylation The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate. go.json http://purl.obolibrary.org/obo/GO_0006019 GO:0021631 biolink:BiologicalProcess optic nerve morphogenesis The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. go.json CN II morphogenesis http://purl.obolibrary.org/obo/GO_0021631 GO:0006016 biolink:BiologicalProcess 2-deoxyribose 1-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. go.json 2-deoxyribose 1-phosphate anabolism|2-deoxyribose 1-phosphate biosynthesis|2-deoxyribose 1-phosphate formation|2-deoxyribose 1-phosphate synthesis http://purl.obolibrary.org/obo/GO_0006016 GO:0006017 biolink:BiologicalProcess deoxyribose 1,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose. go.json deoxyribose 1,5-bisphosphate anabolism|deoxyribose 1,5-bisphosphate biosynthesis|deoxyribose 1,5-bisphosphate formation|deoxyribose 1,5-bisphosphate synthesis http://purl.obolibrary.org/obo/GO_0006017 GO:0021632 biolink:BiologicalProcess optic nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. go.json CN II maturation http://purl.obolibrary.org/obo/GO_0021632 GO:0006014 biolink:BiologicalProcess D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. go.json D-ribose metabolism http://purl.obolibrary.org/obo/GO_0006014 GO:0045666 biolink:BiologicalProcess positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation. go.json activation of neuron differentiation|stimulation of neuron differentiation|up regulation of neuron differentiation|up-regulation of neuron differentiation|upregulation of neuron differentiation http://purl.obolibrary.org/obo/GO_0045666 GO:0006015 biolink:BiologicalProcess 5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. go.json 5-phosphoribose 1-diphosphate anabolism|5-phosphoribose 1-diphosphate biosynthesis|5-phosphoribose 1-diphosphate formation|5-phosphoribose 1-diphosphate synthesis|5-phosphoribosyl-1-pyrophosphate biosynthesis|5-phosphoribosyl-1-pyrophosphate biosynthetic process|PRPP biosynthetic process http://purl.obolibrary.org/obo/GO_0006015 GO:0045667 biolink:BiologicalProcess regulation of osteoblast differentiation Any process that modulates the frequency, rate or extent of osteoblast differentiation. go.json http://purl.obolibrary.org/obo/GO_0045667 GO:0006012 biolink:BiologicalProcess galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. Wikipedia:Galactose go.json galactose metabolism http://purl.obolibrary.org/obo/GO_0006012 GO:0045664 biolink:BiologicalProcess regulation of neuron differentiation Any process that modulates the frequency, rate or extent of neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_0045664 GO:0045665 biolink:BiologicalProcess negative regulation of neuron differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. go.json down regulation of neuron differentiation|down-regulation of neuron differentiation|downregulation of neuron differentiation|inhibition of neuron differentiation http://purl.obolibrary.org/obo/GO_0045665 GO:0006013 biolink:BiologicalProcess mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. go.json mannose metabolism http://purl.obolibrary.org/obo/GO_0006013 GO:0045662 biolink:BiologicalProcess negative regulation of myoblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json down regulation of myoblast differentiation|down-regulation of myoblast differentiation|downregulation of myoblast differentiation|inhibition of myoblast differentiation http://purl.obolibrary.org/obo/GO_0045662 GO:0006010 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006010 GO:0006011 biolink:BiologicalProcess UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. go.json UDP-glucose metabolism http://purl.obolibrary.org/obo/GO_0006011 GO:0045663 biolink:BiologicalProcess positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json activation of myoblast differentiation|stimulation of myoblast differentiation|up regulation of myoblast differentiation|up-regulation of myoblast differentiation|upregulation of myoblast differentiation http://purl.obolibrary.org/obo/GO_0045663 GO:0045660 biolink:BiologicalProcess positive regulation of neutrophil differentiation Any process that activates or increases the frequency, rate or extent of neutrophil differentiation. go.json activation of neutrophil differentiation|stimulation of neutrophil differentiation|up regulation of neutrophil differentiation|up-regulation of neutrophil differentiation|upregulation of neutrophil differentiation http://purl.obolibrary.org/obo/GO_0045660 GO:0045661 biolink:BiologicalProcess regulation of myoblast differentiation Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0045661 GO:0070608 biolink:BiologicalProcess regulation of cell wall (1->3)-alpha-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells. go.json regulation of cell wall 1,3-alpha-glucan anabolism|regulation of cell wall 1,3-alpha-glucan biosynthesis|regulation of cell wall 1,3-alpha-glucan biosynthetic process|regulation of cell wall 1,3-alpha-glucan formation|regulation of cell wall 1,3-alpha-glucan synthesis|regulation of cell wall alpha-1,3-glucan anabolism|regulation of cell wall alpha-1,3-glucan biosynthesis|regulation of cell wall alpha-1,3-glucan biosynthetic process|regulation of cell wall alpha-1,3-glucan formation|regulation of cell wall alpha-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0070608 GO:0070609 biolink:BiologicalProcess regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores. go.json regulation of ascospore wall 1,3-alpha-glucan metabolism|regulation of ascospore wall alpha-1,3 glucan metabolic process|regulation of ascospore wall alpha-1,3 glucan metabolism|regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process http://purl.obolibrary.org/obo/GO_0070609 GO:0070606 biolink:BiologicalProcess regulation of (1->3)-alpha-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. go.json regulation of 1,3-alpha-glucan anabolism|regulation of 1,3-alpha-glucan biosynthesis|regulation of 1,3-alpha-glucan biosynthetic process|regulation of 1,3-alpha-glucan formation|regulation of 1,3-alpha-glucan synthesis|regulation of alpha-1,3 glucan anabolism|regulation of alpha-1,3 glucan biosynthesis|regulation of alpha-1,3 glucan biosynthetic process|regulation of alpha-1,3 glucan formation|regulation of alpha-1,3 glucan synthesis http://purl.obolibrary.org/obo/GO_0070606 GO:0070607 biolink:BiologicalProcess regulation of cell wall (1->3)-alpha-glucan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells. go.json regulation of cell wall 1,3-alpha-glucan metabolic process|regulation of cell wall 1,3-alpha-glucan metabolism|regulation of cell wall alpha-1,3 glucan metabolic process|regulation of cell wall alpha-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0070607 GO:0070604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070604 GO:0070605 biolink:BiologicalProcess regulation of (1->3)-alpha-glucan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. go.json regulation of 1,3-alpha-glucan metabolic process|regulation of 1,3-alpha-glucan metabolism|regulation of alpha-1,3 glucan metabolic process|regulation of alpha-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0070605 GO:0070602 biolink:BiologicalProcess regulation of centromeric sister chromatid cohesion Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome. go.json regulation of sister chromatid cohesion at centromere http://purl.obolibrary.org/obo/GO_0070602 GO:0045668 biolink:BiologicalProcess negative regulation of osteoblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. go.json down regulation of osteoblast differentiation|down-regulation of osteoblast differentiation|downregulation of osteoblast differentiation|inhibition of osteoblast differentiation http://purl.obolibrary.org/obo/GO_0045668 GO:0070603 biolink:CellularComponent SWI/SNF superfamily-type complex A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. go.json BAF-type complex|SWI-SNF global transcription activator complex|SWI-SNF-type complex|SWI/SNF-type complex|SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex http://purl.obolibrary.org/obo/GO_0070603 gocheck_do_not_manually_annotate GO:0045669 biolink:BiologicalProcess positive regulation of osteoblast differentiation Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. go.json activation of osteoblast differentiation|stimulation of osteoblast differentiation|up regulation of osteoblast differentiation|up-regulation of osteoblast differentiation|upregulation of osteoblast differentiation http://purl.obolibrary.org/obo/GO_0045669 GO:0021633 biolink:BiologicalProcess optic nerve structural organization The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. go.json CN II structural organization|optic nerve structural organisation http://purl.obolibrary.org/obo/GO_0021633 GO:0070600 biolink:BiologicalProcess fungal-type cell wall (1->3)-alpha-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores. go.json fungal-type cell wall 1,3-alpha-glucan anabolism|fungal-type cell wall 1,3-alpha-glucan biosynthesis|fungal-type cell wall 1,3-alpha-glucan biosynthetic process|fungal-type cell wall 1,3-alpha-glucan formation|fungal-type cell wall 1,3-alpha-glucan synthesis|fungal-type cell wall alpha-1,3-glucan anabolism|fungal-type cell wall alpha-1,3-glucan biosynthesis|fungal-type cell wall alpha-1,3-glucan biosynthetic process|fungal-type cell wall alpha-1,3-glucan formation|fungal-type cell wall alpha-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0070600 GO:0070601 biolink:BiologicalProcess centromeric sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome. go.json sister chromatid cohesion at centromere http://purl.obolibrary.org/obo/GO_0070601 GO:0021634 biolink:BiologicalProcess optic nerve formation The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. go.json CN II biosynthesis|CN II formation http://purl.obolibrary.org/obo/GO_0021634 GO:0021635 biolink:BiologicalProcess trigeminal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. go.json CN V maturation http://purl.obolibrary.org/obo/GO_0021635 GO:0021636 biolink:BiologicalProcess trigeminal nerve morphogenesis The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. go.json CN V morphogenesis http://purl.obolibrary.org/obo/GO_0021636 GO:0021637 biolink:BiologicalProcess trigeminal nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. go.json CN V structural organization|trigeminal nerve structural organisation http://purl.obolibrary.org/obo/GO_0021637 GO:0021638 biolink:BiologicalProcess trigeminal nerve formation The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. go.json CN V biosynthesis|CN V formation http://purl.obolibrary.org/obo/GO_0021638 GO:0021639 biolink:BiologicalProcess trochlear nerve morphogenesis The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. go.json CH IV morphogenesis http://purl.obolibrary.org/obo/GO_0021639 GO:0045670 biolink:BiologicalProcess regulation of osteoclast differentiation Any process that modulates the frequency, rate or extent of osteoclast differentiation. go.json http://purl.obolibrary.org/obo/GO_0045670 GO:0021620 biolink:BiologicalProcess hypoglossal nerve formation The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. go.json CN XII biosynthesis|CN XII formation http://purl.obolibrary.org/obo/GO_0021620 GO:0021621 biolink:BiologicalProcess hypoglossal nerve structural organization The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. go.json CN XII structural organization|hypoglossal nerve structural organisation http://purl.obolibrary.org/obo/GO_0021621 GO:0045677 biolink:BiologicalProcess negative regulation of R7 cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation. go.json down regulation of R7 differentiation|down-regulation of R7 differentiation|downregulation of R7 differentiation|inhibition of R7 differentiation|negative regulation of R7 differentiation http://purl.obolibrary.org/obo/GO_0045677 GO:0045678 biolink:BiologicalProcess positive regulation of R7 cell differentiation Any process that activates or increases the frequency, rate or extent of R7 cell differentiation. go.json activation of R7 differentiation|positive regulation of R7 differentiation|stimulation of R7 differentiation|up regulation of R7 differentiation|up-regulation of R7 differentiation|upregulation of R7 differentiation http://purl.obolibrary.org/obo/GO_0045678 GO:0045675 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045675 GO:0045676 biolink:BiologicalProcess regulation of R7 cell differentiation Any process that modulates the frequency, rate or extent of R7 differentiation. go.json http://purl.obolibrary.org/obo/GO_0045676 GO:0045673 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045673 GO:0045674 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0045674 GO:0045671 biolink:BiologicalProcess negative regulation of osteoclast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. go.json down regulation of osteoclast differentiation|down-regulation of osteoclast differentiation|downregulation of osteoclast differentiation|inhibition of osteoclast differentiation http://purl.obolibrary.org/obo/GO_0045671 GO:0045672 biolink:BiologicalProcess positive regulation of osteoclast differentiation Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. go.json activation of osteoclast differentiation|stimulation of osteoclast differentiation|up regulation of osteoclast differentiation|up-regulation of osteoclast differentiation|upregulation of osteoclast differentiation http://purl.obolibrary.org/obo/GO_0045672 GO:0070639 biolink:BiologicalProcess vitamin D2 metabolic process The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol. go.json calciferol metabolic process|ergocalciferol metabolic process|vitamin D2 metabolism http://purl.obolibrary.org/obo/GO_0070639 GO:0070637 biolink:BiologicalProcess pyridine nucleoside metabolic process The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose. go.json pyridine nucleoside metabolism http://purl.obolibrary.org/obo/GO_0070637 GO:0070638 biolink:BiologicalProcess pyridine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose. go.json pyridine nucleoside breakdown|pyridine nucleoside catabolism|pyridine nucleoside degradation http://purl.obolibrary.org/obo/GO_0070638 GO:0070635 biolink:MolecularActivity nicotinamide riboside hydrolase activity Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose. MetaCyc:RXN-8441 go.json N-ribosylnicotinamide hydrolase activity|nicotinamide ribonucleoside hydrolase activity http://purl.obolibrary.org/obo/GO_0070635 GO:0045679 biolink:BiologicalProcess regulation of R8 cell differentiation Any process that modulates the frequency, rate or extent of R8 differentiation. go.json http://purl.obolibrary.org/obo/GO_0045679 GO:0070636 biolink:MolecularActivity nicotinic acid riboside hydrolase activity Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose. go.json D-ribosylnicotinate hydrolase activity|D-ribosylnicotinic acid hydrolase activity|nicotinate ribonucleoside hydrolase activity|nicotinate riboside hydrolase activity|nicotinic acid ribonucleoside hydrolase activity http://purl.obolibrary.org/obo/GO_0070636 GO:0070633 biolink:BiologicalProcess transepithelial transport The directed movement of a substance from one side of an epithelium to the other. go.json http://purl.obolibrary.org/obo/GO_0070633 GO:0021622 biolink:BiologicalProcess oculomotor nerve morphogenesis The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. go.json CN III morphogenesis http://purl.obolibrary.org/obo/GO_0021622 GO:0070634 biolink:BiologicalProcess transepithelial ammonium transport The directed movement of ammonium ions from one side of an epithelium to the other. go.json http://purl.obolibrary.org/obo/GO_0070634 GO:0021623 biolink:BiologicalProcess oculomotor nerve formation The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. go.json CN III biosynthesis|CN III formation http://purl.obolibrary.org/obo/GO_0021623 GO:0070631 biolink:BiologicalProcess spindle pole body localization Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells. go.json maintenance of spindle pole body localization|spindle pole body localisation http://purl.obolibrary.org/obo/GO_0070631 GO:0021624 biolink:BiologicalProcess oculomotor nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. go.json CN III structural organization|oculomotor nerve structural organisation http://purl.obolibrary.org/obo/GO_0021624 GO:0070632 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070632 GO:0021625 biolink:BiologicalProcess oculomotor nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. go.json CN III maturation http://purl.obolibrary.org/obo/GO_0021625 GO:0021626 biolink:BiologicalProcess central nervous system maturation A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. go.json http://purl.obolibrary.org/obo/GO_0021626 GO:0070630 biolink:BiologicalProcess (1->4)-alpha-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds. go.json (1->4)-alpha-D-glucan anabolism|(1->4)-alpha-D-glucan biosynthesis|(1->4)-alpha-D-glucan formation|(1->4)-alpha-D-glucan synthesis|1,4-alpha-glucan anabolism|1,4-alpha-glucan biosynthesis|1,4-alpha-glucan biosynthetic process|1,4-alpha-glucan formation|1,4-alpha-glucan synthesis|alpha-1,4 glucan anabolism|alpha-1,4 glucan biosynthesis|alpha-1,4 glucan biosynthetic process|alpha-1,4 glucan formation|alpha-1,4 glucan synthesis http://purl.obolibrary.org/obo/GO_0070630 GO:0021627 biolink:BiologicalProcess olfactory nerve morphogenesis The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. go.json CN I morphogenesis http://purl.obolibrary.org/obo/GO_0021627 GO:0021628 biolink:BiologicalProcess olfactory nerve formation The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. go.json CN I biosynthesis|CN I formation http://purl.obolibrary.org/obo/GO_0021628 GO:0021629 biolink:BiologicalProcess olfactory nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. go.json CN I structural organization|olfactory nerve structural organisation http://purl.obolibrary.org/obo/GO_0021629 GO:0045680 biolink:BiologicalProcess negative regulation of R8 cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation. go.json down regulation of R8 differentiation|down-regulation of R8 differentiation|downregulation of R8 differentiation|inhibition of R8 differentiation|negative regulation of R8 differentiation http://purl.obolibrary.org/obo/GO_0045680 GO:0045681 biolink:BiologicalProcess positive regulation of R8 cell differentiation Any process that activates or increases the frequency, rate or extent of R8 cell differentiation. go.json activation of R8 differentiation|positive regulation of R8 differentiation|stimulation of R8 differentiation|up regulation of R8 differentiation|up-regulation of R8 differentiation|upregulation of R8 differentiation http://purl.obolibrary.org/obo/GO_0045681 GO:0055007 biolink:BiologicalProcess cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. go.json cardiomyocyte differentiation|heart muscle cell differentiation http://purl.obolibrary.org/obo/GO_0055007 GO:0055008 biolink:BiologicalProcess cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac muscle tissue are generated and organized. go.json heart muscle morphogenesis|myocardium morphogenesis http://purl.obolibrary.org/obo/GO_0055008 GO:0055009 biolink:BiologicalProcess atrial cardiac muscle tissue morphogenesis The process in which the anatomical structure of cardiac atrium muscle is generated and organized. go.json atrial heart muscle morphogenesis|atrial myocardium morphogenesis|cardiac atrium muscle morphogenesis http://purl.obolibrary.org/obo/GO_0055009 GO:0021610 biolink:BiologicalProcess facial nerve morphogenesis The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. go.json CN VII morphogenesis http://purl.obolibrary.org/obo/GO_0021610 GO:0045688 biolink:BiologicalProcess regulation of antipodal cell differentiation Any process that modulates the frequency, rate or extent of antipodal cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0045688 GO:0045689 biolink:BiologicalProcess negative regulation of antipodal cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation. go.json down regulation of antipodal cell differentiation|down-regulation of antipodal cell differentiation|downregulation of antipodal cell differentiation|inhibition of antipodal cell differentiation http://purl.obolibrary.org/obo/GO_0045689 GO:0045686 biolink:BiologicalProcess negative regulation of glial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. go.json down regulation of glial cell differentiation|down-regulation of glial cell differentiation|downregulation of glial cell differentiation|inhibition of glial cell differentiation|negative regulation of glia cell differentiation|negative regulation of neuroglia differentiation http://purl.obolibrary.org/obo/GO_0045686 GO:0045687 biolink:BiologicalProcess positive regulation of glial cell differentiation Any process that activates or increases the frequency, rate or extent of glia cell differentiation. go.json activation of glial cell differentiation|positive regulation of glia cell differentiation|positive regulation of neuroglia differentiation|stimulation of glial cell differentiation|up regulation of glial cell differentiation|up-regulation of glial cell differentiation|upregulation of glial cell differentiation http://purl.obolibrary.org/obo/GO_0045687 GO:0045684 biolink:BiologicalProcess positive regulation of epidermis development Any process that activates or increases the frequency, rate or extent of epidermis development. go.json activation of epidermis development|positive regulation of epidermal development|positive regulation of hypodermis development|stimulation of epidermis development|up regulation of epidermis development|up-regulation of epidermis development|upregulation of epidermis development http://purl.obolibrary.org/obo/GO_0045684 GO:0045685 biolink:BiologicalProcess regulation of glial cell differentiation Any process that modulates the frequency, rate or extent of glia cell differentiation. go.json regulation of glia cell differentiation|regulation of neuroglia differentiation http://purl.obolibrary.org/obo/GO_0045685 GO:0045682 biolink:BiologicalProcess regulation of epidermis development Any process that modulates the frequency, rate or extent of epidermis development. go.json regulation of epidermal development|regulation of hypodermis development http://purl.obolibrary.org/obo/GO_0045682 GO:0045683 biolink:BiologicalProcess negative regulation of epidermis development Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. go.json down regulation of epidermis development|down-regulation of epidermis development|downregulation of epidermis development|inhibition of epidermis development|negative regulation of epidermal development|negative regulation of hypodermis development http://purl.obolibrary.org/obo/GO_0045683 GO:0021619 biolink:BiologicalProcess hypoglossal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. go.json CN XII maturation http://purl.obolibrary.org/obo/GO_0021619 GO:0070628 biolink:MolecularActivity proteasome binding Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. go.json http://purl.obolibrary.org/obo/GO_0070628 goslim_chembl GO:0070629 biolink:BiologicalProcess (1->4)-alpha-glucan metabolic process The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds. go.json (1->4)-alpha-D-glucan metabolism|1,4-alpha-D-glucan metabolism|1,4-alpha-glucan metabolism|alpha-1,4 glucan metabolic process|alpha-1,4 glucan metabolism http://purl.obolibrary.org/obo/GO_0070629 GO:0070626 biolink:MolecularActivity (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. EC:4.3.2.2|KEGG_REACTION:R04559|MetaCyc:AICARSYN-RXN|RHEA:23920|Reactome:R-HSA-73800|Reactome:R-HSA-73828 go.json (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|SAICAR-lyase (fumarate forming) activity|adenylosuccinase activity|adenylosuccinate lyase activity|succino AMP-lyase activity http://purl.obolibrary.org/obo/GO_0070626 GO:0070627 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0070627 GO:0070624 biolink:BiologicalProcess negative regulation of thiamine biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. go.json down regulation of thiamine biosynthetic process|down-regulation of thiamine biosynthetic process|downregulation of thiamine biosynthetic process|inhibition of thiamine biosynthetic process|negative regulation of thiamin biosynthetic process|negative regulation of thiamine anabolism|negative regulation of thiamine biosynthesis|negative regulation of thiamine formation|negative regulation of thiamine synthesis http://purl.obolibrary.org/obo/GO_0070624 GO:0070625 biolink:BiologicalProcess zymogen granule exocytosis The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions. go.json http://purl.obolibrary.org/obo/GO_0070625 GO:0070622 biolink:CellularComponent UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits. go.json N-acetylglucosamine-1-phosphotransferase complex|UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex http://purl.obolibrary.org/obo/GO_0070622 GO:0055003 biolink:BiologicalProcess cardiac myofibril assembly The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. go.json cardiac myofibril development|cardiac myofibril morphogenesis|heart myofibril assembly http://purl.obolibrary.org/obo/GO_0055003 GO:0021611 biolink:BiologicalProcess facial nerve formation The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. go.json CN VII biosynthesis|CN VII formation http://purl.obolibrary.org/obo/GO_0021611 GO:0070623 biolink:BiologicalProcess regulation of thiamine biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. go.json regulation of thiamin biosynthetic process|regulation of thiamine anabolism|regulation of thiamine biosynthesis|regulation of thiamine formation|regulation of thiamine synthesis http://purl.obolibrary.org/obo/GO_0070623 GO:0021612 biolink:BiologicalProcess facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. go.json CN VII structural organization|facial nerve structural organisation http://purl.obolibrary.org/obo/GO_0021612 GO:0055004 biolink:BiologicalProcess atrial cardiac myofibril assembly The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. go.json atrial cardiac myofibril development|atrial heart myofibril development http://purl.obolibrary.org/obo/GO_0055004 GO:0070620 biolink:CellularComponent EGFR-Grb2-Sos complex A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. go.json Egfr-Grb2-mSos1 complex, EGF stimulated http://purl.obolibrary.org/obo/GO_0070620 GO:0055005 biolink:BiologicalProcess ventricular cardiac myofibril assembly The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. go.json ventricular cardiac myofibril development|ventricular heart myofibril development http://purl.obolibrary.org/obo/GO_0055005 GO:0021613 biolink:BiologicalProcess facial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. go.json CN VII maturation http://purl.obolibrary.org/obo/GO_0021613 GO:0021614 biolink:BiologicalProcess glossopharyngeal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. go.json CN IX maturation http://purl.obolibrary.org/obo/GO_0021614 GO:0070621 biolink:CellularComponent EGFR-Shc-Grb2-Sos complex A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. go.json http://purl.obolibrary.org/obo/GO_0070621 GO:0055006 biolink:BiologicalProcess cardiac cell development The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. go.json cardiocyte development|heart cell development http://purl.obolibrary.org/obo/GO_0055006 GO:0021615 biolink:BiologicalProcess glossopharyngeal nerve morphogenesis The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. go.json CN IX morphogenesis http://purl.obolibrary.org/obo/GO_0021615 GO:0021616 biolink:BiologicalProcess glossopharyngeal nerve formation The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. go.json CN IX biosynthesis|CN IX formation http://purl.obolibrary.org/obo/GO_0021616 GO:0055001 biolink:BiologicalProcess muscle cell development The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. go.json muscle fiber development|muscle fibre development|myofiber development|myofibre development http://purl.obolibrary.org/obo/GO_0055001 GO:0021617 biolink:BiologicalProcess glossopharyngeal nerve structural organization The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. go.json CN IX structural organization|glossopharyngeal nerve structural organisation http://purl.obolibrary.org/obo/GO_0021617 GO:0021618 biolink:BiologicalProcess hypoglossal nerve morphogenesis The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. go.json CN XII morphogenesis http://purl.obolibrary.org/obo/GO_0021618 GO:0055002 biolink:BiologicalProcess striated muscle cell development The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. go.json http://purl.obolibrary.org/obo/GO_0055002 GO:0045691 biolink:BiologicalProcess regulation of embryo sac central cell differentiation Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation. go.json regulation of female gametophyte central cell differentiation http://purl.obolibrary.org/obo/GO_0045691 GO:0045692 biolink:BiologicalProcess negative regulation of embryo sac central cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation. go.json down regulation of female gametophyte central cell differentiation|down-regulation of female gametophyte central cell differentiation|downregulation of female gametophyte central cell differentiation|inhibition of female gametophyte central cell differentiation|negative regulation of female gametophyte central cell differentiation http://purl.obolibrary.org/obo/GO_0045692 GO:0045690 biolink:BiologicalProcess positive regulation of antipodal cell differentiation Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation. go.json activation of antipodal cell differentiation|stimulation of antipodal cell differentiation|up regulation of antipodal cell differentiation|up-regulation of antipodal cell differentiation|upregulation of antipodal cell differentiation http://purl.obolibrary.org/obo/GO_0045690 GO:0055018 biolink:BiologicalProcess regulation of cardiac muscle fiber development Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. go.json regulation of cardiac muscle fibre development|regulation of heart muscle fiber development http://purl.obolibrary.org/obo/GO_0055018 GO:0055019 biolink:BiologicalProcess negative regulation of cardiac muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. go.json down regulation of cardiac muscle fiber development|down-regulation of cardiac muscle fiber development|downregulation of cardiac muscle fiber development|inhibition of cardiac muscle fiber development|negative regulation of cardiac muscle fibre development|negative regulation of heart muscle fiber development http://purl.obolibrary.org/obo/GO_0055019 GO:0045699 biolink:BiologicalProcess positive regulation of synergid differentiation Any process that activates or increases the frequency, rate or extent of synergid cell differentiation. go.json activation of synergid differentiation|positive regulation of synergid cell differentiation|stimulation of synergid differentiation|up regulation of synergid differentiation|up-regulation of synergid differentiation|upregulation of synergid differentiation http://purl.obolibrary.org/obo/GO_0045699 GO:0045697 biolink:BiologicalProcess regulation of synergid differentiation Any process that modulates the frequency, rate or extent of synergid cell differentiation. go.json regulation of synergid cell differentiation http://purl.obolibrary.org/obo/GO_0045697 GO:0045698 biolink:BiologicalProcess negative regulation of synergid differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation. go.json down regulation of synergid differentiation|down-regulation of synergid differentiation|downregulation of synergid differentiation|inhibition of synergid differentiation|negative regulation of synergid cell differentiation http://purl.obolibrary.org/obo/GO_0045698 GO:0045695 biolink:BiologicalProcess negative regulation of embryo sac egg cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation. go.json down regulation of female gametophyte egg cell differentiation|down-regulation of female gametophyte egg cell differentiation|downregulation of female gametophyte egg cell differentiation|inhibition of female gametophyte egg cell differentiation|negative regulation of female gametophyte egg cell differentiation http://purl.obolibrary.org/obo/GO_0045695 GO:0045696 biolink:BiologicalProcess positive regulation of embryo sac egg cell differentiation Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation. go.json activation of female gametophyte egg cell differentiation|positive regulation of female gametophyte egg cell differentiation|stimulation of female gametophyte egg cell differentiation|up regulation of female gametophyte egg cell differentiation|up-regulation of female gametophyte egg cell differentiation|upregulation of female gametophyte egg cell differentiation http://purl.obolibrary.org/obo/GO_0045696 GO:0045693 biolink:BiologicalProcess positive regulation of embryo sac central cell differentiation Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation. go.json activation of female gametophyte central cell differentiation|positive regulation of female gametophyte central cell differentiation|stimulation of female gametophyte central cell differentiation|up regulation of female gametophyte central cell differentiation|up-regulation of female gametophyte central cell differentiation|upregulation of female gametophyte central cell differentiation http://purl.obolibrary.org/obo/GO_0045693 GO:0045694 biolink:BiologicalProcess regulation of embryo sac egg cell differentiation Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation. go.json regulation of female gametophyte egg cell differentiation http://purl.obolibrary.org/obo/GO_0045694 GO:0021608 biolink:BiologicalProcess accessory nerve formation The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. go.json CN XI biosynthesis|CN XI formation http://purl.obolibrary.org/obo/GO_0021608 GO:0021609 biolink:BiologicalProcess accessory nerve structural organization The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. go.json CN XI structural organization|accessory nerve structural organisation http://purl.obolibrary.org/obo/GO_0021609 GO:0070659 biolink:BiologicalProcess inner ear sensory epithelium regeneration The regrowth of lost or destroyed inner ear sensory epithelia. go.json http://purl.obolibrary.org/obo/GO_0070659 GO:0070657 biolink:BiologicalProcess neuromast regeneration The regrowth of a neuromast following its loss or destruction. go.json http://purl.obolibrary.org/obo/GO_0070657 GO:0070658 biolink:BiologicalProcess neuromast hair cell differentiation involved in neuromast regeneration Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury. go.json http://purl.obolibrary.org/obo/GO_0070658 GO:0055014 biolink:BiologicalProcess atrial cardiac muscle cell development The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ. go.json atrial cardiomyocyte development|atrial heart muscle development http://purl.obolibrary.org/obo/GO_0055014 GO:0021600 biolink:BiologicalProcess abducens nerve structural organization The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. go.json CN VI structural organization|abducens nerve structural organisation http://purl.obolibrary.org/obo/GO_0021600 GO:0070655 biolink:BiologicalProcess mechanosensory epithelium regeneration The regrowth of lost or destroyed mechanosensory epithelia. go.json http://purl.obolibrary.org/obo/GO_0070655 GO:0021601 biolink:BiologicalProcess abducens nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. go.json CN VI maturation http://purl.obolibrary.org/obo/GO_0021601 GO:0070656 biolink:BiologicalProcess mechanoreceptor differentiation involved in mechanosensory epithelium regeneration Differentiation of new mechanoreceptors to replace those lost or destroyed by injury. go.json http://purl.obolibrary.org/obo/GO_0070656 GO:0055015 biolink:BiologicalProcess ventricular cardiac muscle cell development The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. go.json ventricular cardiomyocyte development|ventricular heart muscle cell development http://purl.obolibrary.org/obo/GO_0055015 GO:0070653 biolink:MolecularActivity high-density lipoprotein particle receptor binding Binding to a high-density lipoprotein receptor. go.json HDL receptor binding|high-density lipoprotein receptor binding http://purl.obolibrary.org/obo/GO_0070653 GO:0055016 biolink:BiologicalProcess hypochord development The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta. go.json subnotochordal rod development http://purl.obolibrary.org/obo/GO_0055016 GO:0021602 biolink:BiologicalProcess cranial nerve morphogenesis The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. go.json http://purl.obolibrary.org/obo/GO_0021602 GO:0055017 biolink:BiologicalProcess cardiac muscle tissue growth The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. go.json heart muscle growth http://purl.obolibrary.org/obo/GO_0055017 GO:0070654 biolink:BiologicalProcess sensory epithelium regeneration The regrowth of a sensory epithelium following its loss or destruction. go.json http://purl.obolibrary.org/obo/GO_0070654 GO:0021603 biolink:BiologicalProcess cranial nerve formation The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. go.json http://purl.obolibrary.org/obo/GO_0021603 GO:0070651 biolink:BiologicalProcess nonfunctional rRNA decay An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system. go.json NRD http://purl.obolibrary.org/obo/GO_0070651 GO:0021604 biolink:BiologicalProcess cranial nerve structural organization The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. go.json cranial nerve structural organisation http://purl.obolibrary.org/obo/GO_0021604 GO:0055010 biolink:BiologicalProcess ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. go.json cardiac ventricle muscle morphogenesis|ventricular heart muscle morphogenesis http://purl.obolibrary.org/obo/GO_0055010 GO:0070652 biolink:CellularComponent HAUS complex A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. go.json HAUS augmin complex http://purl.obolibrary.org/obo/GO_0070652 GO:0055011 biolink:BiologicalProcess atrial cardiac muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ. go.json atrial cardiomyocyte differentiation|atrial heart muscle cell differentiation http://purl.obolibrary.org/obo/GO_0055011 GO:0021605 biolink:BiologicalProcess cranial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. go.json http://purl.obolibrary.org/obo/GO_0021605 GO:0021606 biolink:BiologicalProcess accessory nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. go.json CN XI maturation|spinal accessory nerve maturation http://purl.obolibrary.org/obo/GO_0021606 GO:0055012 biolink:BiologicalProcess ventricular cardiac muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. go.json ventricular cardiomyocyte differentiation|ventricular heart muscle cell differentiation http://purl.obolibrary.org/obo/GO_0055012 GO:0021607 biolink:BiologicalProcess accessory nerve morphogenesis The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. go.json CN XI morphogenesis http://purl.obolibrary.org/obo/GO_0021607 GO:0055013 biolink:BiologicalProcess cardiac muscle cell development The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. go.json cardiac muscle fiber development|cardiac muscle fibre development|cardiomyocyte cell development|heart muscle cell development|heart muscle fiber development http://purl.obolibrary.org/obo/GO_0055013 GO:0070650 biolink:BiologicalProcess actin filament bundle distribution Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell. go.json http://purl.obolibrary.org/obo/GO_0070650 GO:0055029 biolink:CellularComponent nuclear DNA-directed RNA polymerase complex A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. go.json http://purl.obolibrary.org/obo/GO_0055029 GO:0055020 biolink:BiologicalProcess positive regulation of cardiac muscle fiber development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. go.json activation of cardiac muscle fiber development|positive regulation of cardiac muscle fibre development|positive regulation of heart muscle fiber development|stimulation of cardiac muscle fiber development|up regulation of cardiac muscle fiber development|up-regulation of cardiac muscle fiber development|upregulation of cardiac muscle fiber development http://purl.obolibrary.org/obo/GO_0055020 GO:0070648 biolink:CellularComponent formin-nucleated actin cable An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth. go.json http://purl.obolibrary.org/obo/GO_0070648 GO:0070649 biolink:BiologicalProcess formin-nucleated actin cable assembly The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. go.json formin-nucleated actin cable formation http://purl.obolibrary.org/obo/GO_0070649 GO:0070646 biolink:BiologicalProcess protein modification by small protein removal A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. go.json http://purl.obolibrary.org/obo/GO_0070646 GO:0070647 biolink:BiologicalProcess protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. go.json http://purl.obolibrary.org/obo/GO_0070647 goslim_drosophila|goslim_pombe|goslim_yeast GO:0055025 biolink:BiologicalProcess positive regulation of cardiac muscle tissue development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. go.json activation of cardiac muscle development|positive regulation of heart muscle development|stimulation of cardiac muscle development|up regulation of cardiac muscle development|up-regulation of cardiac muscle development|upregulation of cardiac muscle development http://purl.obolibrary.org/obo/GO_0055025 GO:0070644 biolink:MolecularActivity vitamin D response element binding Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. go.json VDRE binding http://purl.obolibrary.org/obo/GO_0070644 GO:0055026 biolink:BiologicalProcess negative regulation of cardiac muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. go.json down regulation of cardiac muscle development|down-regulation of cardiac muscle development|downregulation of cardiac muscle development|inhibition of cardiac muscle development|negative regulation of heart muscle development http://purl.obolibrary.org/obo/GO_0055026 GO:0070645 biolink:CellularComponent Ubisch body A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development. go.json orbicule http://purl.obolibrary.org/obo/GO_0070645 GO:0070642 biolink:BiologicalProcess vitamin D5 metabolic process The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol. go.json vitamin D5 metabolism http://purl.obolibrary.org/obo/GO_0070642 GO:0055027 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0055027 GO:0070643 biolink:MolecularActivity vitamin D 25-hydroxylase activity Catalysis of the hydroxylation of C-25 of any form of vitamin D. go.json calciferol 25-hydroxylase activity|cholecalciferol 25-hydroxylase activity|ergocalciferol 25-hydroxylase activity|vitamin D2 25-hydroxylase activity http://purl.obolibrary.org/obo/GO_0070643 GO:0055028 biolink:CellularComponent cortical microtubule Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol. go.json http://purl.obolibrary.org/obo/GO_0055028 GO:0070640 biolink:BiologicalProcess vitamin D3 metabolic process The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. go.json calciol metabolic process|cholecalciferol metabolic process|vitamin D3 metabolism http://purl.obolibrary.org/obo/GO_0070640 GO:0055021 biolink:BiologicalProcess regulation of cardiac muscle tissue growth Any process that modulates the frequency, rate or extent of cardiac muscle growth. go.json http://purl.obolibrary.org/obo/GO_0055021 GO:0070641 biolink:BiologicalProcess vitamin D4 metabolic process The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol. go.json vitamin D4 metabolism http://purl.obolibrary.org/obo/GO_0070641 GO:0055022 biolink:BiologicalProcess negative regulation of cardiac muscle tissue growth Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. go.json down regulation of cardiac muscle growth|down-regulation of cardiac muscle growth|downregulation of cardiac muscle growth|inhibition of cardiac muscle growth|negative regulation of heart muscle growth http://purl.obolibrary.org/obo/GO_0055022 GO:0055023 biolink:BiologicalProcess positive regulation of cardiac muscle tissue growth Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. go.json activation of cardiac muscle growth|positive regulation of heart muscle growth|stimulation of cardiac muscle growth|up regulation of cardiac muscle growth|up-regulation of cardiac muscle growth|upregulation of cardiac muscle growth http://purl.obolibrary.org/obo/GO_0055023 GO:0055024 biolink:BiologicalProcess regulation of cardiac muscle tissue development Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. go.json regulation of heart muscle development http://purl.obolibrary.org/obo/GO_0055024 GO:0031061 biolink:BiologicalProcess negative regulation of histone methylation Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. go.json down regulation of histone methylation|down-regulation of histone methylation|downregulation of histone methylation|inhibition of histone methylation http://purl.obolibrary.org/obo/GO_0031061 GO:0031062 biolink:BiologicalProcess positive regulation of histone methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. go.json activation of histone methylation|stimulation of histone methylation|up regulation of histone methylation|up-regulation of histone methylation|upregulation of histone methylation http://purl.obolibrary.org/obo/GO_0031062 GO:0031060 biolink:BiologicalProcess regulation of histone methylation Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. go.json http://purl.obolibrary.org/obo/GO_0031060 GO:0031069 biolink:BiologicalProcess hair follicle morphogenesis The process in which the anatomical structures of the hair follicle are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0031069 GO:0031067 biolink:BiologicalProcess obsolete negative regulation of histone deacetylation at centromere OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA. go.json down regulation of histone deacetylation at centromere|down-regulation of histone deacetylation at centromere|downregulation of histone deacetylation at centromere|inhibition of histone deacetylation at centromere True http://purl.obolibrary.org/obo/GO_0031067 GO:0031068 biolink:BiologicalProcess obsolete positive regulation of histone deacetylation at centromere OBSOLETE. Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA. go.json activation of histone deacetylation at centromere|stimulation of histone deacetylation at centromere|up regulation of histone deacetylation at centromere|up-regulation of histone deacetylation at centromere|upregulation of histone deacetylation at centromere True http://purl.obolibrary.org/obo/GO_0031068 GO:0031065 biolink:BiologicalProcess positive regulation of histone deacetylation Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. go.json activation of histone deacetylation|stimulation of histone deacetylation|up regulation of histone deacetylation|up-regulation of histone deacetylation|upregulation of histone deacetylation http://purl.obolibrary.org/obo/GO_0031065 GO:0031066 biolink:BiologicalProcess obsolete regulation of histone deacetylation at centromere OBSOLETE. Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA. go.json True http://purl.obolibrary.org/obo/GO_0031066 GO:0031063 biolink:BiologicalProcess regulation of histone deacetylation Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. go.json http://purl.obolibrary.org/obo/GO_0031063 GO:0031064 biolink:BiologicalProcess negative regulation of histone deacetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones. go.json down regulation of histone deacetylation|down-regulation of histone deacetylation|downregulation of histone deacetylation|inhibition of histone deacetylation http://purl.obolibrary.org/obo/GO_0031064 RO:0040036 biolink:OntologyClass results in changes to anatomical or cellular structure RO:0040036 go.json http://purl.obolibrary.org/obo/RO_0040036 GO:0031050 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031050 GO:0031051 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031051 GO:0031058 biolink:BiologicalProcess obsolete positive regulation of histone modification OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone. go.json activation of histone modification|stimulation of histone modification|up regulation of histone modification|up-regulation of histone modification|upregulation of histone modification True http://purl.obolibrary.org/obo/GO_0031058 GO:0031059 biolink:BiologicalProcess obsolete histone deacetylation at centromere OBSOLETE. The removal of acetyl groups from histones in centromeric DNA. go.json True http://purl.obolibrary.org/obo/GO_0031059 GO:0031056 biolink:BiologicalProcess regulation of histone modification Any process that modulates the frequency, rate or extent of the covalent alteration of a histone. go.json http://purl.obolibrary.org/obo/GO_0031056 GO:0031057 biolink:BiologicalProcess obsolete negative regulation of histone modification OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. go.json down regulation of histone modification|down-regulation of histone modification|downregulation of histone modification|inhibition of histone modification True http://purl.obolibrary.org/obo/GO_0031057 GO:0031054 biolink:BiologicalProcess pre-miRNA processing A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. go.json pre-microRNA processing http://purl.obolibrary.org/obo/GO_0031054 GO:0031055 biolink:BiologicalProcess chromatin remodeling at centromere Dynamic structural changes in centromeric DNA. go.json chromatin remodelling at centromere http://purl.obolibrary.org/obo/GO_0031055 GO:0031052 biolink:BiologicalProcess programmed DNA elimination by chromosome breakage Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. go.json chromosome breakage http://purl.obolibrary.org/obo/GO_0031052 GO:0031053 biolink:BiologicalProcess primary miRNA processing A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. go.json pri-miRNA processing|primary miRNA methylation|primary miRNA modification|primary microRNA processing http://purl.obolibrary.org/obo/GO_0031053 GO:0031049 biolink:BiologicalProcess programmed DNA elimination A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing. go.json http://purl.obolibrary.org/obo/GO_0031049 goslim_pir GO:0006089 biolink:BiologicalProcess lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid. go.json 2-hydroxypropanoate metabolic process|2-hydroxypropanoate metabolism|alpha-hydroxypropionate metabolic process|alpha-hydroxypropionate metabolism|lactate metabolism http://purl.obolibrary.org/obo/GO_0006089 GO:0006087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006087 GO:0006088 biolink:BiologicalProcess obsolete acetate to acetyl-CoA OBSOLETE. (Was not defined before being made obsolete). go.json acetate to acetyl-CoA True http://purl.obolibrary.org/obo/GO_0006088 GO:0006085 biolink:BiologicalProcess acetyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. MetaCyc:Acetyl-CoA-Biosynthesis go.json acetyl-CoA anabolism|acetyl-CoA biosynthesis|acetyl-CoA formation|acetyl-CoA synthesis http://purl.obolibrary.org/obo/GO_0006085 GO:0006086 biolink:BiologicalProcess acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. MetaCyc:PYRUVDEHYD-PWY|Reactome:R-HSA-372342.1|Reactome:R-HSA-71397.1 go.json acetyl-CoA anabolism from pyruvate|acetyl-CoA formation from pyruvate|acetyl-CoA synthesis from pyruvate|pyruvate dehydrogenase pathway http://purl.obolibrary.org/obo/GO_0006086 GO:0006094 biolink:BiologicalProcess gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. MetaCyc:GLUCONEO-PWY|Wikipedia:Gluconeogenesis go.json glucose biosynthesis|glucose biosynthetic process http://purl.obolibrary.org/obo/GO_0006094 GO:0031040 biolink:CellularComponent micronucleus A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell. Wikipedia:Micronucleus go.json http://purl.obolibrary.org/obo/GO_0031040 GO:0006095 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006095 GO:0006092 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006092 GO:0006093 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0006093 GO:0006090 biolink:BiologicalProcess pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. MetaCyc:P41-PWY|Wikipedia:Pyruvic_acid go.json pyruvate dehydrogenase bypass|pyruvate metabolism http://purl.obolibrary.org/obo/GO_0006090 goslim_drosophila GO:0006091 biolink:BiologicalProcess generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. go.json energy pathways|intermediary metabolism|metabolic energy generation http://purl.obolibrary.org/obo/GO_0006091 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant|goslim_pombe|goslim_yeast|prokaryote_subset GO:0031047 biolink:BiologicalProcess regulatory ncRNA-mediated gene silencing A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. go.json RNA-dependent gene silencing|RNA-mediated gene silencing|gene silencing by RNA http://purl.obolibrary.org/obo/GO_0031047 goslim_drosophila|goslim_generic GO:0031048 biolink:BiologicalProcess regulatory ncRNA-mediated heterochromatin formation A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginnning of trancription. go.json RNA interference-like chromatin silencing|RNA-dependent heterochromatin formation|RNA-mediated TGS|RNA-mediated chromatin silencing|RNA-mediated heterochromatin formation|RNA-mediated transcriptional silencing|RNAi-directed chromatin silencing|RNAi-like chromatin silencing|chromatin silencing by small RNA|heterochromatin assembly by small RNA|heterochromatin assembly involved in chromatin silencing by small RNA|heterochromatin formation involved in chromatin silencing by small RNA|ncRNA-mediated heterochromatin formation|pre-transcriptional gene silencing by RNA|pre-transcriptional gene silencing by small non-coding RNA|small RNA-mediated heterochromatic silencing|small RNA-mediated heterochromatin formation|small ncRNA-mediated heterochromatin formation|small non-coding RNA-dependent heterochromatin formation http://purl.obolibrary.org/obo/GO_0031048 GO:0031045 biolink:CellularComponent dense core granule Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. NIF_Subcellular:sao772007592 go.json dense core vesicle http://purl.obolibrary.org/obo/GO_0031045 GO:0031046 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031046 GO:0031043 biolink:BiologicalProcess O-glycan processing, core 7 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0031043 gocheck_do_not_annotate GO:0031044 biolink:BiologicalProcess O-glycan processing, core 8 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0031044 gocheck_do_not_annotate GO:0031041 biolink:BiologicalProcess O-glycan processing, core 5 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0031041 gocheck_do_not_annotate GO:0031042 biolink:BiologicalProcess O-glycan processing, core 6 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc. go.json http://purl.obolibrary.org/obo/GO_0031042 gocheck_do_not_annotate GO:0031038 biolink:BiologicalProcess myosin II filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules. go.json myosin II filament assembly or disassembly|myosin II filament organisation|myosin II polymerization or depolymerization http://purl.obolibrary.org/obo/GO_0031038 GO:0031039 biolink:CellularComponent macronucleus A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell. Wikipedia:Macronucleus go.json http://purl.obolibrary.org/obo/GO_0031039 GO:0006098 biolink:BiologicalProcess pentose-phosphate shunt The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). KEGG_PATHWAY:map00030|MetaCyc:PENTOSE-P-PWY|Reactome:R-HSA-71336|Wikipedia:Pentose_phosphate_pathway go.json hexose monophosphate pathway|pentose phosphate pathway|pentose phosphate shunt|pentose-phosphate pathway http://purl.obolibrary.org/obo/GO_0006098 GO:0006099 biolink:BiologicalProcess tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. MetaCyc:P105-PWY|MetaCyc:P42-PWY|MetaCyc:TCA|Wikipedia:Tricarboxylic_acid_cycle go.json Krebs cycle|TCA cycle|citric acid cycle http://purl.obolibrary.org/obo/GO_0006099 GO:0006096 biolink:BiologicalProcess glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. MetaCyc:GLYCOLYSIS-VARIANTS go.json Embden-Meyerhof pathway|Embden-Meyerhof-Parnas pathway|anaerobic glycolysis|glycolysis|modifed Embden-Meyerhof pathway http://purl.obolibrary.org/obo/GO_0006096 GO:0006097 biolink:BiologicalProcess glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. MetaCyc:GLYOXYLATE-BYPASS|Wikipedia:Glyoxylate_cycle go.json glyoxylate bypass http://purl.obolibrary.org/obo/GO_0006097 GO:0031036 biolink:BiologicalProcess myosin II filament assembly The formation of a bipolar filament composed of myosin II molecules. go.json myosin II polymerization http://purl.obolibrary.org/obo/GO_0031036 GO:0031037 biolink:BiologicalProcess myosin II filament disassembly The disassembly of a bipolar filament composed of myosin II molecules. go.json myosin II depolymerization http://purl.obolibrary.org/obo/GO_0031037 GO:0031034 biolink:BiologicalProcess myosin filament assembly The aggregation, arrangement and bonding together of a filament composed of myosin molecules. go.json myosin polymerization http://purl.obolibrary.org/obo/GO_0031034 GO:0031035 biolink:BiologicalProcess myosin filament disassembly The disassembly of a filament composed of myosin molecules. go.json myosin depolymerization http://purl.obolibrary.org/obo/GO_0031035 GO:0031032 biolink:BiologicalProcess actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. go.json actomyosin organization|actomyosin structure organisation|actomyosin structure organization and biogenesis http://purl.obolibrary.org/obo/GO_0031032 GO:0031033 biolink:BiologicalProcess myosin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules. go.json myosin filament assembly or disassembly|myosin filament organisation|myosin polymerization or depolymerization http://purl.obolibrary.org/obo/GO_0031033 GO:0031030 biolink:BiologicalProcess negative regulation of septation initiation signaling Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling. go.json down regulation of septation initiation signaling|down-regulation of septation initiation signaling|downregulation of septation initiation signaling|inhibition of septation initiation signaling|negative regulation of septation initiation network|negative regulation of septation initiation signaling cascade|negative regulation of septation initiation signalling http://purl.obolibrary.org/obo/GO_0031030 GO:0031031 biolink:BiologicalProcess positive regulation of septation initiation signaling Any process that activates or increases the frequency, rate or extent of septation initiation signaling. go.json activation of septation initiation signaling|positive regulation of septation initiation network|positive regulation of septation initiation signaling cascade|positive regulation of septation initiation signalling|stimulation of septation initiation signaling|up regulation of septation initiation signaling|up-regulation of septation initiation signaling|upregulation of septation initiation signaling http://purl.obolibrary.org/obo/GO_0031031 GO:0031029 biolink:BiologicalProcess regulation of septation initiation signaling Any process that modulates the frequency, rate or extent of septation initiation signaling. go.json regulation of septation initiation network|regulation of septation initiation signaling cascade|regulation of septation initiation signalling http://purl.obolibrary.org/obo/GO_0031029 GO:0031027 biolink:CellularComponent glutamate synthase complex (NADH) A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. go.json http://purl.obolibrary.org/obo/GO_0031027 GO:0031028 biolink:BiologicalProcess septation initiation signaling The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis. go.json SIN|septation initiation network|septation initiation signaling cascade|septation initiation signalling http://purl.obolibrary.org/obo/GO_0031028 GO:0006069 biolink:BiologicalProcess ethanol oxidation An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. go.json http://purl.obolibrary.org/obo/GO_0006069 GO:0006067 biolink:BiologicalProcess ethanol metabolic process The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. go.json ethanol metabolism http://purl.obolibrary.org/obo/GO_0006067 GO:0006068 biolink:BiologicalProcess ethanol catabolic process The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. go.json ethanol breakdown|ethanol catabolism|ethanol degradation http://purl.obolibrary.org/obo/GO_0006068 GO:0006065 biolink:BiologicalProcess UDP-glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-4841 go.json UDP-glucuronate anabolism|UDP-glucuronate biosynthesis|UDP-glucuronate formation|UDP-glucuronate synthesis http://purl.obolibrary.org/obo/GO_0006065 GO:0006066 biolink:BiologicalProcess alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. go.json alcohol metabolism http://purl.obolibrary.org/obo/GO_0006066 goslim_drosophila|goslim_pir GO:0006063 biolink:BiologicalProcess uronic acid metabolic process The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. go.json uronic acid metabolism http://purl.obolibrary.org/obo/GO_0006063 GO:0006064 biolink:BiologicalProcess glucuronate catabolic process The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. go.json glucuronate breakdown|glucuronate catabolism|glucuronate degradation http://purl.obolibrary.org/obo/GO_0006064 GO:0006072 biolink:BiologicalProcess glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. go.json glycerol-3-phosphate metabolism http://purl.obolibrary.org/obo/GO_0006072 GO:0006073 biolink:BiologicalProcess obsolete cellular glucan metabolic process OBSOLETE. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. go.json cellular glucan metabolism True http://purl.obolibrary.org/obo/GO_0006073 GO:0006070 biolink:BiologicalProcess octanol metabolic process The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH. go.json octanol metabolism http://purl.obolibrary.org/obo/GO_0006070 GO:0006071 biolink:BiologicalProcess glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. MetaCyc:GLYCEROLMETAB-PWY go.json glycerol metabolism http://purl.obolibrary.org/obo/GO_0006071 GO:0031025 biolink:BiologicalProcess equatorial microtubule organizing center disassembly The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis. go.json equatorial microtubule organising center disassembly http://purl.obolibrary.org/obo/GO_0031025 GO:0031026 biolink:CellularComponent glutamate synthase complex A complex that possesses glutamate synthase activity. go.json http://purl.obolibrary.org/obo/GO_0031026 goslim_pir GO:0031023 biolink:BiologicalProcess microtubule organizing center organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. go.json microtubule organising center organisation|microtubule organizing center organization and biogenesis http://purl.obolibrary.org/obo/GO_0031023 goslim_pir GO:0031024 biolink:BiologicalProcess interphase microtubule organizing center assembly The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center. go.json interphase microtubule organising center biosynthesis|interphase microtubule organising center formation|interphase microtubule organizing center biogenesis|interphase microtubule organizing centre assembly http://purl.obolibrary.org/obo/GO_0031024 GO:0031021 biolink:CellularComponent interphase microtubule organizing center A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus. go.json iMTOC|interphase MTOC|interphase microtubule organising center http://purl.obolibrary.org/obo/GO_0031021 GO:0031022 biolink:BiologicalProcess nuclear migration along microfilament The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. go.json nuclear migration, microfilament-mediated http://purl.obolibrary.org/obo/GO_0031022 GO:0031020 biolink:CellularComponent plastid mRNA editing complex An mRNA editing complex found in a plastid. go.json plastid editosome http://purl.obolibrary.org/obo/GO_0031020 GO:0021691 biolink:BiologicalProcess cerebellar Purkinje cell layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. go.json http://purl.obolibrary.org/obo/GO_0021691 GO:0021692 biolink:BiologicalProcess cerebellar Purkinje cell layer morphogenesis The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. go.json http://purl.obolibrary.org/obo/GO_0021692 GO:0021693 biolink:BiologicalProcess cerebellar Purkinje cell layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. go.json cerebellar Purkinje cell layer structural organisation http://purl.obolibrary.org/obo/GO_0021693 GO:0021694 biolink:BiologicalProcess cerebellar Purkinje cell layer formation The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. go.json http://purl.obolibrary.org/obo/GO_0021694 GO:0031018 biolink:BiologicalProcess endocrine pancreas development The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. go.json http://purl.obolibrary.org/obo/GO_0031018 GO:0021695 biolink:BiologicalProcess cerebellar cortex development The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. go.json http://purl.obolibrary.org/obo/GO_0021695 GO:0021696 biolink:BiologicalProcess cerebellar cortex morphogenesis The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. go.json http://purl.obolibrary.org/obo/GO_0021696 GO:0031019 biolink:CellularComponent mitochondrial mRNA editing complex An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates. go.json mitochondrial editosome http://purl.obolibrary.org/obo/GO_0031019 GO:0031016 biolink:BiologicalProcess pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. Wikipedia:Pancreas go.json http://purl.obolibrary.org/obo/GO_0031016 GO:0021697 biolink:BiologicalProcess cerebellar cortex formation The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. go.json http://purl.obolibrary.org/obo/GO_0021697 GO:0031017 biolink:BiologicalProcess exocrine pancreas development The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. go.json http://purl.obolibrary.org/obo/GO_0031017 GO:0021698 biolink:BiologicalProcess cerebellar cortex structural organization The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. go.json cerebellar cortex structural organisation http://purl.obolibrary.org/obo/GO_0021698 GO:0045600 biolink:BiologicalProcess positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. go.json activation of fat cell differentiation|positive regulation of adipocyte cell differentiation|positive regulation of adipocyte differentiation|stimulation of fat cell differentiation|up regulation of fat cell differentiation|up-regulation of fat cell differentiation|upregulation of fat cell differentiation http://purl.obolibrary.org/obo/GO_0045600 GO:0045601 biolink:BiologicalProcess regulation of endothelial cell differentiation Any process that modulates the frequency, rate or extent of endothelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0045601 GO:0006078 biolink:BiologicalProcess (1->6)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans. go.json 1,6-beta-glucan anabolism|1,6-beta-glucan biosynthesis|1,6-beta-glucan biosynthetic process|1,6-beta-glucan formation|1,6-beta-glucan synthesis|beta-1,6 glucan anabolism|beta-1,6 glucan biosynthesis|beta-1,6 glucan biosynthetic process|beta-1,6 glucan formation|beta-1,6 glucan synthesis http://purl.obolibrary.org/obo/GO_0006078 GO:0006079 biolink:BiologicalProcess (1->6)-beta-D-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans. go.json 1,6-beta-D-glucan breakdown|1,6-beta-D-glucan catabolic process|1,6-beta-D-glucan catabolism|1,6-beta-D-glucan degradation|beta-1,6 glucan breakdown|beta-1,6 glucan catabolic process|beta-1,6 glucan catabolism|beta-1,6 glucan degradation http://purl.obolibrary.org/obo/GO_0006079 GO:0006076 biolink:BiologicalProcess (1->3)-beta-D-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans. go.json 1,3-beta-D-glucan catabolic process|1,3-beta-glucan breakdown|1,3-beta-glucan catabolism|1,3-beta-glucan degradation|beta-1,3 glucan breakdown|beta-1,3 glucan catabolic process|beta-1,3 glucan catabolism|beta-1,3 glucan degradation http://purl.obolibrary.org/obo/GO_0006076 GO:0006077 biolink:BiologicalProcess (1->6)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds. go.json 1,6-beta-glucan metabolic process|1,6-beta-glucan metabolism|beta-1,6 glucan metabolic process|beta-1,6 glucan metabolism http://purl.obolibrary.org/obo/GO_0006077 GO:0006074 biolink:BiologicalProcess (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds. go.json 1,3-beta-D-glucan metabolic process|1,3-beta-D-glucan metabolism|1,3-beta-glucan metabolic process|beta-1,3 glucan metabolic process|beta-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0006074 GO:0006075 biolink:BiologicalProcess (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds. go.json 1,3-beta-D-glucan biosynthetic process|1,3-beta-glucan anabolism|1,3-beta-glucan biosynthesis|1,3-beta-glucan formation|1,3-beta-glucan synthesis|beta-1,3 glucan anabolism|beta-1,3 glucan biosynthesis|beta-1,3 glucan biosynthetic process|beta-1,3 glucan formation|beta-1,3 glucan synthesis http://purl.obolibrary.org/obo/GO_0006075 GO:0021690 biolink:BiologicalProcess cerebellar molecular layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. go.json http://purl.obolibrary.org/obo/GO_0021690 GO:0045608 biolink:BiologicalProcess negative regulation of inner ear auditory receptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation. go.json down regulation of auditory receptor cell differentiation|down-regulation of auditory receptor cell differentiation|downregulation of auditory receptor cell differentiation|inhibition of auditory receptor cell differentiation|negative regulation of auditory hair cell differentiation|negative regulation of auditory receptor cell differentiation http://purl.obolibrary.org/obo/GO_0045608 GO:0006083 biolink:BiologicalProcess acetate metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid. go.json acetate metabolism http://purl.obolibrary.org/obo/GO_0006083 GO:0045609 biolink:BiologicalProcess positive regulation of inner ear auditory receptor cell differentiation Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation. go.json activation of auditory receptor cell differentiation|positive regulation of auditory hair cell differentiation|positive regulation of auditory receptor cell differentiation|stimulation of auditory receptor cell differentiation|up regulation of auditory receptor cell differentiation|up-regulation of auditory receptor cell differentiation|upregulation of auditory receptor cell differentiation http://purl.obolibrary.org/obo/GO_0045609 GO:0006084 biolink:BiologicalProcess acetyl-CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. go.json acetyl coenzyme A metabolic process|acetyl coenzyme A metabolism|acetyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0006084 GO:0045606 biolink:BiologicalProcess positive regulation of epidermal cell differentiation Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. go.json activation of epidermal cell differentiation|positive regulation of hypodermal cell differentiation|stimulation of epidermal cell differentiation|up regulation of epidermal cell differentiation|up-regulation of epidermal cell differentiation|upregulation of epidermal cell differentiation http://purl.obolibrary.org/obo/GO_0045606 GO:0006081 biolink:BiologicalProcess cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. go.json aldehyde metabolism|alkanal metabolic process|alkanal metabolism http://purl.obolibrary.org/obo/GO_0006081 goslim_pir GO:0006082 biolink:BiologicalProcess organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. go.json organic acid metabolism http://purl.obolibrary.org/obo/GO_0006082 goslim_pir GO:0045607 biolink:BiologicalProcess regulation of inner ear auditory receptor cell differentiation Any process that modulates the frequency, rate or extent of auditory hair cell differentiation. go.json regulation of auditory hair cell differentiation|regulation of auditory receptor cell differentiation http://purl.obolibrary.org/obo/GO_0045607 GO:0045604 biolink:BiologicalProcess regulation of epidermal cell differentiation Any process that modulates the frequency, rate or extent of epidermal cell differentiation. go.json regulation of hypodermal cell differentiation http://purl.obolibrary.org/obo/GO_0045604 GO:0045605 biolink:BiologicalProcess negative regulation of epidermal cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. go.json down regulation of epidermal cell differentiation|down-regulation of epidermal cell differentiation|downregulation of epidermal cell differentiation|inhibition of epidermal cell differentiation|negative regulation of hypodermal cell differentiation http://purl.obolibrary.org/obo/GO_0045605 GO:0006080 biolink:BiologicalProcess substituted mannan metabolic process The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units. go.json substituted mannan metabolism http://purl.obolibrary.org/obo/GO_0006080 GO:0045602 biolink:BiologicalProcess negative regulation of endothelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. go.json down regulation of endothelial cell differentiation|down-regulation of endothelial cell differentiation|downregulation of endothelial cell differentiation|inhibition of endothelial cell differentiation http://purl.obolibrary.org/obo/GO_0045602 GO:0045603 biolink:BiologicalProcess positive regulation of endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. go.json activation of endothelial cell differentiation|stimulation of endothelial cell differentiation|up regulation of endothelial cell differentiation|up-regulation of endothelial cell differentiation|upregulation of endothelial cell differentiation http://purl.obolibrary.org/obo/GO_0045603 GO:0021699 biolink:BiologicalProcess cerebellar cortex maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. go.json http://purl.obolibrary.org/obo/GO_0021699 GO:0031014 biolink:MolecularActivity troponin T binding Binding to troponin T, the tropomyosin-binding subunit of the troponin complex. go.json http://purl.obolibrary.org/obo/GO_0031014 GO:0031015 biolink:CellularComponent obsolete karyopherin docking complex OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p. go.json Asm4p-containing complex|karyopherin docking complex|nuclear pore subcomplex True http://purl.obolibrary.org/obo/GO_0031015 GO:0031012 biolink:CellularComponent extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. NIF_Subcellular:nlx_subcell_20090513|Wikipedia:Extracellular_matrix go.json matrisome|proteinaceous extracellular matrix http://purl.obolibrary.org/obo/GO_0031012 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|prokaryote_subset GO:0031013 biolink:MolecularActivity troponin I binding Binding to troponin I, the inhibitory subunit of the troponin complex. go.json http://purl.obolibrary.org/obo/GO_0031013 GO:0031010 biolink:CellularComponent ISWI-type complex Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair. go.json http://purl.obolibrary.org/obo/GO_0031010 GO:0031011 biolink:CellularComponent Ino80 complex A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. go.json INO80 chromatin remodeling complex http://purl.obolibrary.org/obo/GO_0031011 GO:0021680 biolink:BiologicalProcess cerebellar Purkinje cell layer development The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. go.json http://purl.obolibrary.org/obo/GO_0021680 GO:0021681 biolink:BiologicalProcess cerebellar granular layer development The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. go.json http://purl.obolibrary.org/obo/GO_0021681 GO:0021682 biolink:BiologicalProcess nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0021682 GO:0031009 biolink:CellularComponent plastid ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in a plastid. go.json http://purl.obolibrary.org/obo/GO_0031009 GO:0021683 biolink:BiologicalProcess cerebellar granular layer morphogenesis The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. go.json http://purl.obolibrary.org/obo/GO_0021683 GO:0031007 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031007 GO:0021684 biolink:BiologicalProcess cerebellar granular layer formation The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. go.json http://purl.obolibrary.org/obo/GO_0021684 GO:0031008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031008 GO:0021685 biolink:BiologicalProcess cerebellar granular layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. go.json cerebellar granular layer structural organisation http://purl.obolibrary.org/obo/GO_0021685 GO:0031005 biolink:MolecularActivity filamin binding Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. go.json ABP-278/276 binding|ABP-280 binding|ABPL binding|alpha-filamin binding|beta-filamin binding|filamin A binding|filamin B binding|filamin C binding|filamin-1 binding|filamin-2 binding|filamin-3 binding|filamin-A binding|filamin-B binding|filamin-C binding|gamma-filamin binding http://purl.obolibrary.org/obo/GO_0031005 GO:0021686 biolink:BiologicalProcess cerebellar granular layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. go.json http://purl.obolibrary.org/obo/GO_0021686 GO:0006049 biolink:BiologicalProcess UDP-N-acetylglucosamine catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. go.json UDP-N-acetylglucosamine breakdown|UDP-N-acetylglucosamine catabolism|UDP-N-acetylglucosamine degradation http://purl.obolibrary.org/obo/GO_0006049 GO:0021687 biolink:BiologicalProcess cerebellar molecular layer morphogenesis The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. go.json http://purl.obolibrary.org/obo/GO_0021687 GO:0031006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0031006 GO:0006047 biolink:BiologicalProcess UDP-N-acetylglucosamine metabolic process The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. go.json UDP-N-acetylglucosamine metabolism http://purl.obolibrary.org/obo/GO_0006047 GO:0045611 biolink:BiologicalProcess negative regulation of hemocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation. go.json down regulation of hemocyte differentiation|down-regulation of hemocyte differentiation|downregulation of hemocyte differentiation|inhibition of hemocyte differentiation|negative regulation of arthropod blood cell differentiation http://purl.obolibrary.org/obo/GO_0045611 GO:0006048 biolink:BiologicalProcess UDP-N-acetylglucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. MetaCyc:UDPNAGSYN-PWY go.json UDP-GlcNAc biosynthesis|UDP-GlcNAc biosynthetic process|UDP-N-acetylglucosamine anabolism|UDP-N-acetylglucosamine biosynthesis|UDP-N-acetylglucosamine formation|UDP-N-acetylglucosamine synthesis http://purl.obolibrary.org/obo/GO_0006048 GO:0045612 biolink:BiologicalProcess positive regulation of hemocyte differentiation Any process that activates or increases the frequency, rate or extent of hemocyte differentiation. go.json activation of hemocyte differentiation|positive regulation of arthropod blood cell differentiation|stimulation of hemocyte differentiation|up regulation of hemocyte differentiation|up-regulation of hemocyte differentiation|upregulation of hemocyte differentiation http://purl.obolibrary.org/obo/GO_0045612 GO:0006045 biolink:BiologicalProcess N-acetylglucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. go.json N-acetylglucosamine anabolism|N-acetylglucosamine biosynthesis|N-acetylglucosamine formation|N-acetylglucosamine synthesis http://purl.obolibrary.org/obo/GO_0006045 GO:0006046 biolink:BiologicalProcess N-acetylglucosamine catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. go.json N-acetylglucosamine breakdown|N-acetylglucosamine catabolism|N-acetylglucosamine degradation http://purl.obolibrary.org/obo/GO_0006046 GO:0045610 biolink:BiologicalProcess regulation of hemocyte differentiation Any process that modulates the frequency, rate or extent of hemocyte differentiation. go.json regulation of arthropod blood cell differentiation http://purl.obolibrary.org/obo/GO_0045610 GO:0006043 biolink:BiologicalProcess glucosamine catabolic process The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. MetaCyc:GLUAMCAT-PWY go.json chitosamine catabolic process|chitosamine catabolism|glucosamine breakdown|glucosamine catabolism|glucosamine degradation http://purl.obolibrary.org/obo/GO_0006043 GO:0006044 biolink:BiologicalProcess N-acetylglucosamine metabolic process The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. go.json N-acetylglucosamine metabolism http://purl.obolibrary.org/obo/GO_0006044 GO:0006041 biolink:BiologicalProcess glucosamine metabolic process The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. go.json chitosamine metabolic process|chitosamine metabolism|glucosamine metabolism http://purl.obolibrary.org/obo/GO_0006041 GO:0006042 biolink:BiologicalProcess glucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. go.json chitosamine biosynthesis|chitosamine biosynthetic process|glucosamine anabolism|glucosamine biosynthesis|glucosamine formation|glucosamine synthesis http://purl.obolibrary.org/obo/GO_0006042 GO:0045619 biolink:BiologicalProcess regulation of lymphocyte differentiation Any process that modulates the frequency, rate or extent of lymphocyte differentiation. go.json regulation of lymphocyte development http://purl.obolibrary.org/obo/GO_0045619 GO:0006050 biolink:BiologicalProcess mannosamine metabolic process The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. go.json mannosamine metabolism http://purl.obolibrary.org/obo/GO_0006050 GO:0006051 biolink:BiologicalProcess N-acetylmannosamine metabolic process The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. go.json N-acetylmannosamine metabolism http://purl.obolibrary.org/obo/GO_0006051 GO:0045617 biolink:BiologicalProcess negative regulation of keratinocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. go.json down regulation of keratinocyte differentiation|down-regulation of keratinocyte differentiation|downregulation of keratinocyte differentiation|inhibition of keratinocyte differentiation http://purl.obolibrary.org/obo/GO_0045617 GO:0045618 biolink:BiologicalProcess positive regulation of keratinocyte differentiation Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. go.json activation of keratinocyte differentiation|stimulation of keratinocyte differentiation|up regulation of keratinocyte differentiation|up-regulation of keratinocyte differentiation|upregulation of keratinocyte differentiation http://purl.obolibrary.org/obo/GO_0045618 GO:0045615 biolink:BiologicalProcess positive regulation of plasmatocyte differentiation Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation. go.json activation of plasmatocyte differentiation|stimulation of plasmatocyte differentiation|up regulation of plasmatocyte differentiation|up-regulation of plasmatocyte differentiation|upregulation of plasmatocyte differentiation http://purl.obolibrary.org/obo/GO_0045615 GO:0045616 biolink:BiologicalProcess regulation of keratinocyte differentiation Any process that modulates the frequency, rate or extent of keratinocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0045616 GO:0045613 biolink:BiologicalProcess regulation of plasmatocyte differentiation Any process that modulates the frequency, rate or extent of plasmatocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0045613 GO:0045614 biolink:BiologicalProcess negative regulation of plasmatocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation. go.json down regulation of plasmatocyte differentiation|down-regulation of plasmatocyte differentiation|downregulation of plasmatocyte differentiation|inhibition of plasmatocyte differentiation http://purl.obolibrary.org/obo/GO_0045614 GO:0021688 biolink:BiologicalProcess cerebellar molecular layer formation The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. go.json http://purl.obolibrary.org/obo/GO_0021688 GO:0031003 biolink:CellularComponent actin tubule A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together. go.json http://purl.obolibrary.org/obo/GO_0031003 GO:0021689 biolink:BiologicalProcess cerebellar molecular layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. go.json cerebellar molecular layer structural organisation http://purl.obolibrary.org/obo/GO_0021689 GO:0031004 biolink:CellularComponent potassium ion-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex. go.json Kdp system complex http://purl.obolibrary.org/obo/GO_0031004 GO:0031001 biolink:BiologicalProcess response to brefeldin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. go.json http://purl.obolibrary.org/obo/GO_0031001 GO:0031002 biolink:CellularComponent actin rod A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions. go.json http://purl.obolibrary.org/obo/GO_0031002 GO:0031000 biolink:BiologicalProcess response to caffeine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. go.json http://purl.obolibrary.org/obo/GO_0031000 GO:0021670 biolink:BiologicalProcess lateral ventricle development The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. go.json http://purl.obolibrary.org/obo/GO_0021670 GO:0021671 biolink:BiologicalProcess rhombomere 7 morphogenesis The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021671 GO:0021672 biolink:BiologicalProcess rhombomere 7 structural organization The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 7 structural organisation http://purl.obolibrary.org/obo/GO_0021672 GO:0021673 biolink:BiologicalProcess rhombomere 7 formation The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021673 GO:0021674 biolink:BiologicalProcess rhombomere 8 morphogenesis The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021674 GO:0021675 biolink:BiologicalProcess nerve development The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0021675 GO:0021676 biolink:BiologicalProcess rhombomere 8 structural organization The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. go.json rhombomere 8 structural organisation http://purl.obolibrary.org/obo/GO_0021676 GO:0006058 biolink:BiologicalProcess mannoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues. go.json mannoprotein breakdown|mannoprotein catabolism|mannoprotein degradation http://purl.obolibrary.org/obo/GO_0006058 GO:0045622 biolink:BiologicalProcess regulation of T-helper cell differentiation Any process that modulates the frequency, rate or extent of T-helper cell differentiation. go.json regulation of T-helper cell development http://purl.obolibrary.org/obo/GO_0045622 GO:0006059 biolink:BiologicalProcess hexitol metabolic process The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule. go.json hexitol metabolism|sugar alcohol (hexitol) metabolic process|sugar alcohol (hexitol) metabolism http://purl.obolibrary.org/obo/GO_0006059 GO:0045623 biolink:BiologicalProcess negative regulation of T-helper cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation. go.json down regulation of T-helper cell differentiation|down-regulation of T-helper cell differentiation|downregulation of T-helper cell differentiation|inhibition of T-helper cell differentiation|negative regulation of T-helper cell development http://purl.obolibrary.org/obo/GO_0045623 GO:0045620 biolink:BiologicalProcess negative regulation of lymphocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. go.json down regulation of lymphocyte differentiation|down-regulation of lymphocyte differentiation|downregulation of lymphocyte differentiation|inhibition of lymphocyte differentiation|negative regulation of lymphocyte development http://purl.obolibrary.org/obo/GO_0045620 GO:0006056 biolink:BiologicalProcess mannoprotein metabolic process The chemical reactions and pathways involving a mannoprotein, a protein that contains covalently bound mannose residues. go.json mannoprotein metabolism http://purl.obolibrary.org/obo/GO_0006056 GO:0006057 biolink:BiologicalProcess mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of a mannoprotein, a protein that contains covalently bound mannose residues. go.json mannoprotein anabolism|mannoprotein biosynthesis|mannoprotein formation|mannoprotein synthesis http://purl.obolibrary.org/obo/GO_0006057 GO:0045621 biolink:BiologicalProcess positive regulation of lymphocyte differentiation Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. go.json activation of lymphocyte differentiation|positive regulation of lymphocyte development|stimulation of lymphocyte differentiation|up regulation of lymphocyte differentiation|up-regulation of lymphocyte differentiation|upregulation of lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0045621 GO:0006054 biolink:BiologicalProcess N-acetylneuraminate metabolic process The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. go.json N-acetylneuraminate metabolism|sialic acid metabolic process|sialic acid metabolism http://purl.obolibrary.org/obo/GO_0006054 GO:0006055 biolink:BiologicalProcess CMP-N-acetylneuraminate biosynthetic process The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate. go.json CMP-N-acetylneuraminate anabolism|CMP-N-acetylneuraminate biosynthesis|CMP-N-acetylneuraminate formation|CMP-N-acetylneuraminate synthesis http://purl.obolibrary.org/obo/GO_0006055 GO:0006052 biolink:BiologicalProcess N-acetylmannosamine biosynthetic process The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. go.json N-acetylmannosamine anabolism|N-acetylmannosamine biosynthesis|N-acetylmannosamine formation|N-acetylmannosamine synthesis http://purl.obolibrary.org/obo/GO_0006052 GO:0006053 biolink:BiologicalProcess N-acetylmannosamine catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. go.json N-acetylmannosamine breakdown|N-acetylmannosamine catabolism|N-acetylmannosamine degradation http://purl.obolibrary.org/obo/GO_0006053 GO:0006061 biolink:BiologicalProcess sorbitol biosynthetic process The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. go.json sorbitol anabolism|sorbitol biosynthesis|sorbitol formation|sorbitol synthesis http://purl.obolibrary.org/obo/GO_0006061 GO:0006062 biolink:BiologicalProcess sorbitol catabolic process The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. MetaCyc:SORBDEG-PWY go.json sorbitol breakdown|sorbitol catabolism|sorbitol degradation http://purl.obolibrary.org/obo/GO_0006062 GO:0045628 biolink:BiologicalProcess regulation of T-helper 2 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. go.json regulation of T-helper 2 cell development http://purl.obolibrary.org/obo/GO_0045628 GO:0006060 biolink:BiologicalProcess sorbitol metabolic process The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. MetaCyc:P461-PWY go.json sorbitol metabolism http://purl.obolibrary.org/obo/GO_0006060 GO:0045629 biolink:BiologicalProcess negative regulation of T-helper 2 cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation. go.json down regulation of T-helper 2 cell differentiation|down-regulation of T-helper 2 cell differentiation|downregulation of T-helper 2 cell differentiation|inhibition of T-helper 2 cell differentiation|negative regulation of T-helper 2 cell development http://purl.obolibrary.org/obo/GO_0045629 GO:0045626 biolink:BiologicalProcess negative regulation of T-helper 1 cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation. go.json down regulation of T-helper 1 cell differentiation|down-regulation of T-helper 1 cell differentiation|downregulation of T-helper 1 cell differentiation|inhibition of T-helper 1 cell differentiation|negative regulation of T-helper 1 cell development http://purl.obolibrary.org/obo/GO_0045626 GO:0045627 biolink:BiologicalProcess positive regulation of T-helper 1 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation. go.json activation of T-helper 1 cell differentiation|positive regulation of T-helper 1 cell development|stimulation of T-helper 1 cell differentiation|up regulation of T-helper 1 cell differentiation|up-regulation of T-helper 1 cell differentiation|upregulation of T-helper 1 cell differentiation http://purl.obolibrary.org/obo/GO_0045627 GO:0045624 biolink:BiologicalProcess positive regulation of T-helper cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. go.json activation of T-helper cell differentiation|positive regulation of T-helper cell development|stimulation of T-helper cell differentiation|up regulation of T-helper cell differentiation|up-regulation of T-helper cell differentiation|upregulation of T-helper cell differentiation http://purl.obolibrary.org/obo/GO_0045624 GO:0045625 biolink:BiologicalProcess regulation of T-helper 1 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation. go.json regulation of T-helper 1 cell development http://purl.obolibrary.org/obo/GO_0045625 GO:0021677 biolink:BiologicalProcess rhombomere 8 formation The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. go.json http://purl.obolibrary.org/obo/GO_0021677 GO:0021678 biolink:BiologicalProcess third ventricle development The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina. go.json http://purl.obolibrary.org/obo/GO_0021678 GO:0021679 biolink:BiologicalProcess cerebellar molecular layer development The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. go.json http://purl.obolibrary.org/obo/GO_0021679 GO:0045592 biolink:BiologicalProcess regulation of cumulus cell differentiation Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation. go.json regulation of ovarian cumulus cell differentiation http://purl.obolibrary.org/obo/GO_0045592 GO:0045593 biolink:BiologicalProcess negative regulation of cumulus cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation. go.json down regulation of cumulus cell differentiation|down-regulation of cumulus cell differentiation|downregulation of cumulus cell differentiation|inhibition of cumulus cell differentiation|negative regulation of ovarian cumulus cell differentiation http://purl.obolibrary.org/obo/GO_0045593 GO:0045590 biolink:BiologicalProcess negative regulation of regulatory T cell differentiation Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells. go.json down regulation of regulatory T cell differentiation|down-regulation of regulatory T cell differentiation|downregulation of regulatory T cell differentiation|inhibition of regulatory T cell differentiation|negative regulation of regulatory T cell development|negative regulation of regulatory T lymphocyte differentiation|negative regulation of regulatory T-cell differentiation|negative regulation of regulatory T-lymphocyte differentiation|negative regulation of suppressor T cell differentiation|negative regulation of suppressor T-cell differentiation http://purl.obolibrary.org/obo/GO_0045590 GO:0045591 biolink:BiologicalProcess positive regulation of regulatory T cell differentiation Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. go.json activation of regulatory T cell differentiation|positive regulation of regulatory T cell development|positive regulation of regulatory T lymphocyte differentiation|positive regulation of regulatory T-cell differentiation|positive regulation of regulatory T-lymphocyte differentiation|positive regulation of suppressor T cell differentiation|positive regulation of suppressor T-cell differentiation|stimulation of regulatory T cell differentiation|up regulation of regulatory T cell differentiation|up-regulation of regulatory T cell differentiation|upregulation of regulatory T cell differentiation http://purl.obolibrary.org/obo/GO_0045591 GO:0045598 biolink:BiologicalProcess regulation of fat cell differentiation Any process that modulates the frequency, rate or extent of adipocyte differentiation. go.json regulation of adipocyte cell differentiation|regulation of adipocyte differentiation http://purl.obolibrary.org/obo/GO_0045598 GO:0045599 biolink:BiologicalProcess negative regulation of fat cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. go.json down regulation of fat cell differentiation|down-regulation of fat cell differentiation|downregulation of fat cell differentiation|inhibition of fat cell differentiation|negative regulation of adipocyte cell differentiation|negative regulation of adipocyte differentiation http://purl.obolibrary.org/obo/GO_0045599 GO:0045596 biolink:BiologicalProcess negative regulation of cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. go.json down regulation of cell differentiation|down-regulation of cell differentiation|downregulation of cell differentiation|inhibition of cell differentiation http://purl.obolibrary.org/obo/GO_0045596 GO:0045597 biolink:BiologicalProcess positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation. go.json activation of cell differentiation|stimulation of cell differentiation|up regulation of cell differentiation|up-regulation of cell differentiation|upregulation of cell differentiation http://purl.obolibrary.org/obo/GO_0045597 GO:0045594 biolink:BiologicalProcess positive regulation of cumulus cell differentiation Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation. go.json activation of cumulus cell differentiation|positive regulation of ovarian cumulus cell differentiation|stimulation of cumulus cell differentiation|up regulation of cumulus cell differentiation|up-regulation of cumulus cell differentiation|upregulation of cumulus cell differentiation http://purl.obolibrary.org/obo/GO_0045594 GO:0045595 biolink:BiologicalProcess regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. go.json http://purl.obolibrary.org/obo/GO_0045595 GO:0070558 biolink:CellularComponent alphaM-beta2 integrin-CD63 complex A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family. go.json ITGAM-ITGB2-CD63 complex http://purl.obolibrary.org/obo/GO_0070558 GO:0070559 biolink:CellularComponent lysosomal multienzyme complex A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism. go.json GALNS-lysosomal hydrolase 1.27 MDa complex http://purl.obolibrary.org/obo/GO_0070559 GO:0070556 biolink:CellularComponent TAF4B-containing transcription factor TFIID complex A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4. go.json TFIID complex, B-cell specific http://purl.obolibrary.org/obo/GO_0070556 GO:0070557 biolink:CellularComponent PCNA-p21 complex A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication. go.json http://purl.obolibrary.org/obo/GO_0070557 GO:0070554 biolink:CellularComponent synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof). go.json SNARE complex (Stx3, Snap25, Vamp2, Cplx1)|Stx3-Snap25-Vamp2-Cplx1 complex http://purl.obolibrary.org/obo/GO_0070554 GO:0070555 biolink:BiologicalProcess response to interleukin-1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. go.json response to IL-1 http://purl.obolibrary.org/obo/GO_0070555 GO:0070552 biolink:CellularComponent BRISC complex A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. go.json http://purl.obolibrary.org/obo/GO_0070552 GO:0070553 biolink:MolecularActivity nicotinic acid receptor activity Combining with nicotinic acid to initiate a change in cell activity. go.json niacin receptor activity http://purl.obolibrary.org/obo/GO_0070553 GO:0070550 biolink:BiologicalProcess rDNA chromatin condensation The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase. go.json rDNA condensation|rDNA packaging http://purl.obolibrary.org/obo/GO_0070550 GO:0070551 biolink:MolecularActivity endoribonuclease activity, cleaving siRNA-paired mRNA Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters. Reactome:R-HSA-9820842 go.json argonaute endoribonuclease activity http://purl.obolibrary.org/obo/GO_0070551 GO:0070549 biolink:BiologicalProcess siRNA-mediated gene silencing by inhibition of translation An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs. go.json RNA interference, negative regulation of translation|down regulation of translation involved in RNA interference|down-regulation of translation involved in RNA interference|downregulation of translation involved in RNA interference|inhibition of translation involved in RNA interference|negative regulation of translation involved in RNA interference http://purl.obolibrary.org/obo/GO_0070549 GO:0070547 biolink:MolecularActivity L-tyrosine aminotransferase activity Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid. go.json http://purl.obolibrary.org/obo/GO_0070547 GO:0070548 biolink:MolecularActivity L-glutamine aminotransferase activity Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid. go.json http://purl.obolibrary.org/obo/GO_0070548 GO:0070545 biolink:CellularComponent PeBoW complex A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. go.json http://purl.obolibrary.org/obo/GO_0070545 GO:0070546 biolink:MolecularActivity L-phenylalanine aminotransferase activity Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid. go.json http://purl.obolibrary.org/obo/GO_0070546 GO:0070543 biolink:BiologicalProcess response to linoleic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus. go.json response to linoleate http://purl.obolibrary.org/obo/GO_0070543 GO:0070544 biolink:BiologicalProcess histone H3-K36 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone. go.json H3K36 demethylation http://purl.obolibrary.org/obo/GO_0070544 gocheck_do_not_annotate GO:0070541 biolink:BiologicalProcess response to platinum ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus. go.json response to platinum http://purl.obolibrary.org/obo/GO_0070541 GO:0070542 biolink:BiologicalProcess response to fatty acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0070542 GO:0070540 biolink:MolecularActivity stearic acid binding Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid. go.json http://purl.obolibrary.org/obo/GO_0070540 GO:0070570 biolink:BiologicalProcess regulation of neuron projection regeneration Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. go.json http://purl.obolibrary.org/obo/GO_0070570 GO:0070571 biolink:BiologicalProcess negative regulation of neuron projection regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. go.json growth cone collapse http://purl.obolibrary.org/obo/GO_0070571 GO:0070578 biolink:CellularComponent RISC-loading complex A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. go.json RLC|miRLC|microRNA loading complex http://purl.obolibrary.org/obo/GO_0070578 GO:0070579 biolink:MolecularActivity methylcytosine dioxygenase activity Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2. EC:1.14.11.80|Reactome:R-HSA-5220952|Reactome:R-HSA-5220990|Reactome:R-HSA-5221014|Reactome:R-HSA-9817458 go.json http://purl.obolibrary.org/obo/GO_0070579 GO:0070576 biolink:MolecularActivity vitamin D 24-hydroxylase activity Catalysis of the hydroxylation of C-24 of any form of vitamin D. go.json calciferol 24-hydroxylase activity|cholecalciferol 24-hydroxylase activity|ergocalciferol 24-hydroxylase activity|vitamin D2 24-hydroxylase activity|vitamin D3 24-hydroxylase activity http://purl.obolibrary.org/obo/GO_0070576 GO:0070577 biolink:MolecularActivity lysine-acetylated histone binding Binding to a histone in which a lysine residue has been modified by acetylation. go.json acetylated histone residue binding http://purl.obolibrary.org/obo/GO_0070577 GO:0070574 biolink:BiologicalProcess cadmium ion transmembrane transport A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json cadmium ion membrane transport|transmembrane cadmium transport http://purl.obolibrary.org/obo/GO_0070574 GO:0070575 biolink:BiologicalProcess peptide mating pheromone maturation involved in regulation of pheromone-induced unidirectional conjugation The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation. go.json peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation|peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation http://purl.obolibrary.org/obo/GO_0070575 GO:0070572 biolink:BiologicalProcess positive regulation of neuron projection regeneration Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. go.json http://purl.obolibrary.org/obo/GO_0070572 GO:0070573 biolink:MolecularActivity metallodipeptidase activity Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Reactome:R-HSA-2022398|Reactome:R-HSA-2022405|Reactome:R-HSA-2065355 go.json metallo-exo-dipeptidase activity|metalloexodipeptidase activity http://purl.obolibrary.org/obo/GO_0070573 GO:0070560 biolink:BiologicalProcess protein secretion by platelet The regulated release of proteins by a platelet or group of platelets. go.json http://purl.obolibrary.org/obo/GO_0070560 GO:0070569 biolink:MolecularActivity uridylyltransferase activity Catalysis of the transfer of an uridylyl group to an acceptor. go.json uridyl transferase activity|uridyltransferase activity http://purl.obolibrary.org/obo/GO_0070569 GO:0070567 biolink:MolecularActivity cytidylyltransferase activity Catalysis of the transfer of a cytidylyl group to an acceptor. go.json http://purl.obolibrary.org/obo/GO_0070567 GO:0070568 biolink:MolecularActivity guanylyltransferase activity Catalysis of the transfer of a guanylyl group to an acceptor. go.json http://purl.obolibrary.org/obo/GO_0070568 GO:0070565 biolink:CellularComponent telomere-telomerase complex A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome. go.json http://purl.obolibrary.org/obo/GO_0070565 GO:0070566 biolink:MolecularActivity adenylyltransferase activity Catalysis of the transfer of an adenylyl group to an acceptor. go.json http://purl.obolibrary.org/obo/GO_0070566 GO:0070563 biolink:BiologicalProcess negative regulation of vitamin D receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity. go.json down regulation of vitamin D receptor signaling pathway|down-regulation of vitamin D receptor signaling pathway|downregulation of vitamin D receptor signaling pathway|inhibition of vitamin D receptor signaling pathway|negative regulation of VDR signaling pathway|negative regulation of VDR signalling pathway|negative regulation vitamin D receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070563 GO:0070564 biolink:BiologicalProcess positive regulation of vitamin D receptor signaling pathway Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity. go.json activation of vitamin D receptor signaling pathway|positive regulation of VDR signaling pathway|positive regulation of vitamin D receptor signalling pathway|stimulation of vitamin D receptor signaling pathway|up regulation of vitamin D receptor signaling pathway|up-regulation of vitamin D receptor signaling pathway|upregulation of vitamin D receptor signaling pathway http://purl.obolibrary.org/obo/GO_0070564 GO:0070561 biolink:BiologicalProcess vitamin D receptor signaling pathway The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands. go.json VDR signaling pathway|calcitriol signaling pathway|vitamin D receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070561 GO:0070562 biolink:BiologicalProcess regulation of vitamin D receptor signaling pathway Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity. go.json regulation of VDR signaling pathway|regulation of vitamin D receptor signalling pathway http://purl.obolibrary.org/obo/GO_0070562 GO:0070592 biolink:BiologicalProcess cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall. go.json cell wall polysaccharide anabolism|cell wall polysaccharide biosynthesis|cell wall polysaccharide synthesis http://purl.obolibrary.org/obo/GO_0070592 GO:0070593 biolink:BiologicalProcess dendrite self-avoidance The process in which dendrites recognize and avoid contact with sister dendrites from the same cell. go.json dendrite repulsion http://purl.obolibrary.org/obo/GO_0070593 GO:0070590 biolink:BiologicalProcess spore wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore. go.json http://purl.obolibrary.org/obo/GO_0070590 GO:0070591 biolink:BiologicalProcess ascospore wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall. go.json http://purl.obolibrary.org/obo/GO_0070591 GO:0070598 biolink:BiologicalProcess cell wall (1->3)-alpha-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells. go.json cell wall 1,3-alpha-glucan anabolism|cell wall 1,3-alpha-glucan biosynthesis|cell wall 1,3-alpha-glucan biosynthetic process|cell wall 1,3-alpha-glucan formation|cell wall 1,3-alpha-glucan synthesis|cell wall alpha-1,3-glucan anabolism|cell wall alpha-1,3-glucan biosynthesis|cell wall alpha-1,3-glucan biosynthetic process|cell wall alpha-1,3-glucan formation|cell wall alpha-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0070598 GO:0070599 biolink:BiologicalProcess fungal-type cell wall (1->3)-alpha-glucan metabolic process The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores. go.json ascospore wall 1,3-alpha-glucan metabolic process|ascospore wall 1,3-alpha-glucan metabolism|ascospore wall alpha-1,3 glucan metabolic process|ascospore wall alpha-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0070599 GO:0070596 biolink:BiologicalProcess (1->3)-alpha-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. go.json 1,3-alpha-glucan anabolism|1,3-alpha-glucan biosynthesis|1,3-alpha-glucan biosynthetic process|1,3-alpha-glucan formation|1,3-alpha-glucan synthesis|alpha-1,3 glucan anabolism|alpha-1,3 glucan biosynthesis|alpha-1,3 glucan biosynthetic process|alpha-1,3 glucan formation|alpha-1,3 glucan synthesis http://purl.obolibrary.org/obo/GO_0070596 GO:0070597 biolink:BiologicalProcess cell wall (1->3)-alpha-glucan metabolic process The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells. go.json cell wall 1,3-alpha-glucan metabolic process|cell wall 1,3-alpha-glucan metabolism|cell wall alpha-1,3 glucan metabolic process|cell wall alpha-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0070597 GO:0070594 biolink:MolecularActivity juvenile hormone response element binding Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone. go.json JHRE binding http://purl.obolibrary.org/obo/GO_0070594 GO:0070595 biolink:BiologicalProcess (1->3)-alpha-glucan metabolic process The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. go.json 1,3-alpha-glucan metabolic process|1,3-alpha-glucan metabolism|alpha-1,3 glucan metabolic process|alpha-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0070595 GO:0070581 biolink:BiologicalProcess rolling circle DNA replication A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon. go.json rolling circle replication http://purl.obolibrary.org/obo/GO_0070581 GO:0070582 biolink:BiologicalProcess theta DNA replication A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template. go.json theta replication http://purl.obolibrary.org/obo/GO_0070582 GO:0070580 biolink:BiologicalProcess base J metabolic process The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J. go.json base J metabolism|beta-D-glucosyl-HOMedU metabolic process|beta-D-glucosyl-hydroxymethyluracil metabolism http://purl.obolibrary.org/obo/GO_0070580 GO:0070589 biolink:BiologicalProcess obsolete cellular component macromolecule biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component. go.json cellular component macromolecule biosynthesis True http://purl.obolibrary.org/obo/GO_0070589 GO:0070587 biolink:BiologicalProcess regulation of cell-cell adhesion involved in gastrulation Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation. go.json http://purl.obolibrary.org/obo/GO_0070587 GO:0070588 biolink:BiologicalProcess calcium ion transmembrane transport A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json calcium ion membrane transport|transmembrane calcium transport http://purl.obolibrary.org/obo/GO_0070588 GO:0070585 biolink:BiologicalProcess protein localization to mitochondrion A process in which a protein is transported to, or maintained in, a location within the mitochondrion. go.json protein localisation in mitochondrion|protein localization in mitochondrion http://purl.obolibrary.org/obo/GO_0070585 GO:0070586 biolink:BiologicalProcess cell-cell adhesion involved in gastrulation The attachment of one cell to another cell affecting gastrulation. go.json http://purl.obolibrary.org/obo/GO_0070586 GO:0070583 biolink:BiologicalProcess spore membrane bending pathway The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore. go.json FSM bending|ascospore-type prospore membrane bending|forespore membrane bending http://purl.obolibrary.org/obo/GO_0070583 GO:0070584 biolink:BiologicalProcess mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0070584 GO:1990630 biolink:CellularComponent IRE1-RACK1-PP2A complex A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A. go.json ERN1-RACK1-PP2A complex|IRE1alpha-RACK1-PP2A complex http://purl.obolibrary.org/obo/GO_1990630 GO:1990631 biolink:MolecularActivity ErbB-4 class receptor binding Binding to the protein-tyrosine kinase receptor ErbB-4/HER4. go.json HER4 receptor binding http://purl.obolibrary.org/obo/GO_1990631 GO:1990632 biolink:BiologicalProcess branching involved in submandibular gland morphogenesis The process in which the branching structure of the submandibular gland is generated and organized. go.json submandibular gland branching morphogenesis|submandibular gland ductal branching http://purl.obolibrary.org/obo/GO_1990632 GO:1990637 biolink:BiologicalProcess response to prolactin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation. go.json http://purl.obolibrary.org/obo/GO_1990637 GO:1990638 biolink:BiologicalProcess response to granulocyte colony-stimulating factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. go.json response to G-CSF http://purl.obolibrary.org/obo/GO_1990638 GO:1990639 biolink:MolecularActivity obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. go.json inositol-3,4,5-trisphosphate 5-phosphatase activity True http://purl.obolibrary.org/obo/GO_1990639 GO:1990633 biolink:CellularComponent mutator focus A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules. go.json http://purl.obolibrary.org/obo/GO_1990633 GO:1990634 biolink:MolecularActivity protein phosphatase 5 binding Binding to protein phosphatase 5. go.json protein phosphatase T binding http://purl.obolibrary.org/obo/GO_1990634 GO:1990635 biolink:CellularComponent proximal dendrite The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). go.json http://purl.obolibrary.org/obo/GO_1990635 GO:1990636 biolink:BiologicalProcess reproductive senescence A life cycle stage during which the reproductive capacity and fitness of an organism declines. go.json ovarian senescence http://purl.obolibrary.org/obo/GO_1990636 gocheck_do_not_annotate GO:1990640 biolink:MolecularActivity inositol-2,4,5-triphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_1990640 GO:1990641 biolink:BiologicalProcess response to iron ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion. go.json http://purl.obolibrary.org/obo/GO_1990641 GO:1990642 biolink:BiologicalProcess obsolete response to castration OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads. go.json response to castration True http://purl.obolibrary.org/obo/GO_1990642 GO:1990643 biolink:BiologicalProcess cellular response to granulocyte colony-stimulating factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. go.json http://purl.obolibrary.org/obo/GO_1990643 GO:1990648 biolink:MolecularActivity inositol-4,5,6-triphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_1990648 GO:1990649 biolink:MolecularActivity inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_1990649 GO:1990644 biolink:MolecularActivity microtubule site clamp The binding activity of a molecule that attaches the spindle microtubules to the kinetochore. go.json http://purl.obolibrary.org/obo/GO_1990644 GO:1990645 biolink:BiologicalProcess obsolete phosphorylase dephosphorylation OBSOLETE. The modification of phosphorylases by removal of phosphate groups. go.json phosphorylase dephosphorylation True http://purl.obolibrary.org/obo/GO_1990645 GO:1990646 biolink:BiologicalProcess cellular response to prolactin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. go.json http://purl.obolibrary.org/obo/GO_1990646 GO:1990647 biolink:CellularComponent C/EBP complex A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities. go.json C/EBP homodimer complex|C/EBP transcription factor complex|C/EBPalpha complex|C/EBPalpha homodimer complex|C/EBPbeta complex|C/EBPbeta homodimer complex http://purl.obolibrary.org/obo/GO_1990647 GO:1990651 biolink:MolecularActivity inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_1990651 GO:1990652 biolink:BiologicalProcess obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage. go.json positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1990652 GO:1990653 biolink:BiologicalProcess obsolete monounsaturated fatty acid biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids. go.json True http://purl.obolibrary.org/obo/GO_1990653 GO:1990654 biolink:BiologicalProcess sebum secreting cell proliferation The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum. go.json sebocyte proliferation http://purl.obolibrary.org/obo/GO_1990654 GO:1990650 biolink:MolecularActivity inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_1990650 GO:1990659 biolink:BiologicalProcess sequestering of manganese ion The process of binding or confining manganese ions such that they are separated from other components of a biological system. go.json manganese ion retention|manganese ion sequestering|manganese ion sequestration|manganese ion storage|retention of manganese ion|sequestration of manganese ion|storage of manganese ion http://purl.obolibrary.org/obo/GO_1990659 GO:1990655 biolink:MolecularActivity 4 iron, 3 sulfur cluster binding Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria. go.json 4Fe-3S cluster binding http://purl.obolibrary.org/obo/GO_1990655 GO:1990656 biolink:BiologicalProcess t-SNARE clustering The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies. go.json http://purl.obolibrary.org/obo/GO_1990656 GO:1990657 biolink:CellularComponent iNOS-S100A8/A9 complex A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine. go.json http://purl.obolibrary.org/obo/GO_1990657 GO:1990658 biolink:CellularComponent transnitrosylase complex A transferase complex which is capable of transferring nitrogenous groups from one component to another. go.json transferase complex, transferring nitrogenous groups http://purl.obolibrary.org/obo/GO_1990658 GO:1990662 biolink:CellularComponent S100A9 complex A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility. go.json S100A9 homodimer http://purl.obolibrary.org/obo/GO_1990662 GO:1990663 biolink:MolecularActivity dihydroorotate dehydrogenase (fumarate) activity Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate. EC:1.3.98.1|RHEA:30059 go.json http://purl.obolibrary.org/obo/GO_1990663 GO:1990664 biolink:CellularComponent Nkx-2.5 complex A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes. go.json NKX.2-5 homodimer complex|NKX2.5 complex|NKX2E homodimer complex|Nkx-2.5 homodimer complex http://purl.obolibrary.org/obo/GO_1990664 GO:1990665 biolink:CellularComponent AnxA2-p11 complex A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10). go.json (A2.p11)2 complex|(p11)2.(AnxA2)2 complex|Annexin A2 tetramer|Annexin A2-p11 complex|AnxA2.p11 complex|AnxA2:S100A10 heterotetramer http://purl.obolibrary.org/obo/GO_1990665 GO:1990660 biolink:CellularComponent calprotectin complex A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. go.json calprotectin heterodimer http://purl.obolibrary.org/obo/GO_1990660 GO:1990661 biolink:CellularComponent S100A8 complex A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4). go.json S100A8 homodimer http://purl.obolibrary.org/obo/GO_1990661 GO:1990666 biolink:CellularComponent PCSK9-LDLR complex A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. go.json PCSK9.LDLR complex|PCSK9/LDL-R complex|PCSK9:EGF-A complex|PCSK9:low-density lipoprotein receptor complex http://purl.obolibrary.org/obo/GO_1990666 GO:1990667 biolink:CellularComponent PCSK9-AnxA2 complex A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2). go.json PCSK9-Annexin A2 complex|PCSK9.AnxA2 complex|PCSK9:ANXA2 complex http://purl.obolibrary.org/obo/GO_1990667 GO:1990668 biolink:BiologicalProcess vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles. go.json vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane|vesicle fusion with ER-Golgi intermediate compartment membrane|vesicle fusion with ERGIC membrane|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane http://purl.obolibrary.org/obo/GO_1990668 GO:1990669 biolink:BiologicalProcess endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. go.json ER-Golgi intermediate compartment derived vesicle fusion with ER membrane|endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane http://purl.obolibrary.org/obo/GO_1990669 GO:1990608 biolink:BiologicalProcess mitotic spindle pole body localization A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location. go.json establishment and maintenance of spindle pole body localization|establishment of spindle pole body localisation|establishment of spindle pole body localization|mitotic spindle pole body localization to nuclear envelope|spindle pole body docking|spindle pole body localisation in nuclear envelope|spindle pole body localization in nuclear envelope|spindle pole body localization to nuclear envelope|spindle pole body positioning http://purl.obolibrary.org/obo/GO_1990608 GO:1990609 biolink:MolecularActivity glutamate-cysteine ligase regulator activity Binds to and modulates the activity of glutamate-cysteine ligase. go.json http://purl.obolibrary.org/obo/GO_1990609 GO:1990604 biolink:CellularComponent IRE1-TRAF2-ASK1 complex A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). go.json ERN1-TRAF2-ASK1 complex http://purl.obolibrary.org/obo/GO_1990604 GO:1990605 biolink:MolecularActivity GU repeat RNA binding Binding to an RNA molecule containing GU repeats. go.json http://purl.obolibrary.org/obo/GO_1990605 GO:1990606 biolink:MolecularActivity membrane scission GTPase motor activity Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_1990606 GO:1990607 biolink:BiologicalProcess obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint. go.json True http://purl.obolibrary.org/obo/GO_1990607 GO:1990600 biolink:MolecularActivity single-stranded DNA endodeoxyribonuclease activator activity Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity. go.json http://purl.obolibrary.org/obo/GO_1990600 GO:1990601 biolink:MolecularActivity 5' overhang single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks. go.json http://purl.obolibrary.org/obo/GO_1990601 GO:1990602 biolink:CellularComponent obsolete importin alpha-subunit nuclear import complex OBSOLETE. A trimeric protein complex which functions to transport the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14). go.json Cdm-Mago-Tsu complex|Importin13-Mago-Tsu complex True http://purl.obolibrary.org/obo/GO_1990602 GO:1990603 biolink:BiologicalProcess dark adaptation The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light. go.json http://purl.obolibrary.org/obo/GO_1990603 GO:1990610 biolink:MolecularActivity acetolactate synthase regulator activity Binds to and modulates the activity of acetolactate synthase. go.json http://purl.obolibrary.org/obo/GO_1990610 GO:1990619 biolink:BiologicalProcess histone H3-K9 deacetylation The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone. go.json http://purl.obolibrary.org/obo/GO_1990619 gocheck_do_not_annotate GO:1990615 biolink:CellularComponent Kelch-containing formin regulatory complex A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p. go.json Bud14-Kel1-Kel2 complex|KFRC complex http://purl.obolibrary.org/obo/GO_1990615 GO:1990616 biolink:BiologicalProcess magnesium ion export from mitochondrion The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore. go.json magnesium ion efflux from mitochondrion http://purl.obolibrary.org/obo/GO_1990616 GO:1990617 biolink:CellularComponent CHOP-ATF4 complex A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits. go.json ATF4-CHOP heterodimer|CHOP-ATF4 heterodimer|CHOP-CREB-2 complex|CHOP/ATF4 complex|GADD153-ATF4 complex http://purl.obolibrary.org/obo/GO_1990617 GO:1990618 biolink:CellularComponent obsolete ANPR-A:ANP complex OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. go.json ANPR-A:ANP complex True http://purl.obolibrary.org/obo/GO_1990618 GO:1990611 biolink:BiologicalProcess regulation of cytoplasmic translational initiation in response to stress Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_1990611 GO:1990612 biolink:CellularComponent Sad1-Kms1 LINC complex A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair. go.json http://purl.obolibrary.org/obo/GO_1990612 GO:1990613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990613 GO:1990614 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990614 GO:1990620 biolink:CellularComponent ANPR-A receptor complex A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. go.json NPR1 receptor complex http://purl.obolibrary.org/obo/GO_1990620 GO:1990621 biolink:CellularComponent ESCRT IV complex An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1. go.json ESCRT-IV|VPS4A-VPS4B|VPS4A/B complex|Vps4 complex|Vps4-Vta1 complex|Vta1-Vps4 complex|vacuolar protein sorting-associated complex http://purl.obolibrary.org/obo/GO_1990621 GO:1990626 biolink:BiologicalProcess mitochondrial outer membrane fusion The membrane organization process that joins two mitochondrial outer membranes to form a single membrane. go.json mitochondrion outer membrane fusion http://purl.obolibrary.org/obo/GO_1990626 GO:1990627 biolink:BiologicalProcess mitochondrial inner membrane fusion The membrane organization process that joins two mitochondrial inner membranes to form a single membrane. go.json mitochondrion inner membrane fusion http://purl.obolibrary.org/obo/GO_1990627 GO:1990628 biolink:CellularComponent obsolete Sigma-E factor negative regulation complex OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell. go.json RseA-RseB-RpoE complex|Sigma-E factor negative regulation complex True http://purl.obolibrary.org/obo/GO_1990628 GO:1990629 biolink:CellularComponent phospholamban complex A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels. go.json cardiac PLB complex|cardiac PLN complex|cardiac phospholamban complex http://purl.obolibrary.org/obo/GO_1990629 GO:1990622 biolink:CellularComponent CHOP-ATF3 complex A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits. go.json ATF3-CHOP complex|CHOP-ATF3 heterodimer|CHOP-ATF3 heterodimeric complex|GADD153-ATF3 complex http://purl.obolibrary.org/obo/GO_1990622 GO:1990623 biolink:CellularComponent Herring body The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively. go.json neurosecretory body http://purl.obolibrary.org/obo/GO_1990623 GO:1990624 biolink:MolecularActivity guanyl nucleotide exchange factor inhibitor activity Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor. go.json http://purl.obolibrary.org/obo/GO_1990624 GO:1990625 biolink:BiologicalProcess negative regulation of cytoplasmic translational initiation in response to stress Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress. go.json http://purl.obolibrary.org/obo/GO_1990625 GO:0050268 biolink:MolecularActivity coniferyl-alcohol dehydrogenase activity Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH. EC:1.1.1.194|MetaCyc:RXN-2602|RHEA:22444 go.json coniferyl-alcohol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050268 GO:0050269 biolink:MolecularActivity coniferyl-aldehyde dehydrogenase activity Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+. EC:1.2.1.68|MetaCyc:RXN-1241 go.json coniferyl aldehyde:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050269 GO:0050266 biolink:MolecularActivity rosmarinate synthase activity Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate. EC:2.3.1.140|MetaCyc:RXN-7633|RHEA:22344 go.json 4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity|caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity|caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity|rosmarinic acid synthase activity http://purl.obolibrary.org/obo/GO_0050266 GO:0050267 biolink:MolecularActivity rubber cis-polyprenylcistransferase activity Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit. EC:2.5.1.20|MetaCyc:2.5.1.20-RXN|RHEA:18801 go.json cis-prenyl transferase activity|isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity|poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity|rubber allyltransferase activity|rubber polymerase activity|rubber prenyltransferase activity|rubber transferase activity http://purl.obolibrary.org/obo/GO_0050267 GO:0015939 biolink:BiologicalProcess pantothenate metabolic process The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. go.json pantothenate metabolism|vitamin B5 metabolic process|vitamin B5 metabolism http://purl.obolibrary.org/obo/GO_0015939 GO:1902018 biolink:BiologicalProcess negative regulation of cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. go.json down regulation of ciliogenesis|down regulation of cilium assembly|down regulation of cilium biogenesis|down-regulation of ciliogenesis|down-regulation of cilium assembly|down-regulation of cilium biogenesis|downregulation of ciliogenesis|downregulation of cilium assembly|downregulation of cilium biogenesis|inhibition of ciliogenesis|inhibition of cilium assembly|inhibition of cilium biogenesis|negative regulation of ciliogenesis|negative regulation of cilium biogenesis http://purl.obolibrary.org/obo/GO_1902018 GO:1902019 biolink:BiologicalProcess regulation of cilium-dependent cell motility Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. go.json regulation of ciliary cell motility|regulation of cilium cell motility http://purl.obolibrary.org/obo/GO_1902019 GO:1902016 biolink:BiologicalProcess poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid. go.json poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid anabolism|poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis|poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid formation|poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid synthesis|poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis|poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process http://purl.obolibrary.org/obo/GO_1902016 GO:1902017 biolink:BiologicalProcess regulation of cilium assembly Any process that modulates the frequency, rate or extent of cilium assembly. go.json regulation of ciliogenesis|regulation of cilium biogenesis http://purl.obolibrary.org/obo/GO_1902017 GO:1902014 biolink:BiologicalProcess poly(glycerol phosphate) teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of poly(glycerol phosphate) teichoic acid. go.json poly(glycerol phosphate) teichoic acid anabolism|poly(glycerol phosphate) teichoic acid biosynthesis|poly(glycerol phosphate) teichoic acid formation|poly(glycerol phosphate) teichoic acid synthesis http://purl.obolibrary.org/obo/GO_1902014 GO:0015935 biolink:CellularComponent small ribosomal subunit The smaller of the two subunits of a ribosome. go.json ribosomal small subunit http://purl.obolibrary.org/obo/GO_0015935 goslim_pir GO:1902015 biolink:BiologicalProcess poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process The chemical reactions and pathways involving poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid. go.json poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism|poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process|poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism http://purl.obolibrary.org/obo/GO_1902015 GO:0015936 biolink:BiologicalProcess coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. go.json CoA metabolism|coenzyme A metabolism http://purl.obolibrary.org/obo/GO_0015936 GO:1902012 biolink:BiologicalProcess poly(ribitol phosphate) teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of poly(ribitol phosphate) teichoic acid. go.json poly(ribitol phosphate) teichoic acid anabolism|poly(ribitol phosphate) teichoic acid biosynthesis|poly(ribitol phosphate) teichoic acid formation|poly(ribitol phosphate) teichoic acid synthesis http://purl.obolibrary.org/obo/GO_1902012 GO:0015937 biolink:BiologicalProcess coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. MetaCyc:COA-PWY|MetaCyc:PANTOSYN-PWY|MetaCyc:PWY-4221 go.json CoA biosynthesis|coenzyme A anabolism|coenzyme A biosynthesis|coenzyme A formation|coenzyme A synthesis http://purl.obolibrary.org/obo/GO_0015937 GO:0015938 biolink:BiologicalProcess coenzyme A catabolic process The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. go.json CoA catabolism|coenzyme A breakdown|coenzyme A catabolism|coenzyme A degradation http://purl.obolibrary.org/obo/GO_0015938 GO:1902013 biolink:BiologicalProcess poly(glycerol phosphate) teichoic acid metabolic process The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid. go.json poly(glycerol phosphate) teichoic acid metabolism http://purl.obolibrary.org/obo/GO_1902013 GO:1902021 biolink:BiologicalProcess regulation of bacterial-type flagellum-dependent cell motility Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. go.json regulation of bacterial-type flagellar cell motility|regulation of bacterial-type flagellum cell motility|regulation of flagellin-based flagellar cell motility http://purl.obolibrary.org/obo/GO_1902021 GO:0015931 biolink:BiologicalProcess nucleobase-containing compound transport The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json nucleobase, nucleoside, nucleotide and nucleic acid transport http://purl.obolibrary.org/obo/GO_0015931 goslim_pir|goslim_yeast GO:1902022 biolink:BiologicalProcess L-lysine transport The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1902022 GO:0015932 biolink:MolecularActivity nucleobase-containing compound transmembrane transporter activity Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. go.json nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015932 GO:0015933 biolink:MolecularActivity obsolete flavin-containing electron transporter OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins. go.json flavin-containing electron transporter True http://purl.obolibrary.org/obo/GO_0015933 GO:1902020 biolink:BiologicalProcess negative regulation of cilium-dependent cell motility Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. go.json down regulation of ciliary cell motility|down-regulation of ciliary cell motility|downregulation of ciliary cell motility|inhibition of ciliary cell motility|negative regulation of ciliary cell motility|negative regulation of cilium cell motility http://purl.obolibrary.org/obo/GO_1902020 GO:0015934 biolink:CellularComponent large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). go.json ribosomal large subunit http://purl.obolibrary.org/obo/GO_0015934 GO:0015930 biolink:MolecularActivity glutamate synthase activity Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. go.json http://purl.obolibrary.org/obo/GO_0015930 GO:0050260 biolink:MolecularActivity ribose-5-phosphate-ammonia ligase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate. EC:6.3.4.7|KEGG_REACTION:R01053|MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN|RHEA:13777 go.json 5-phosphoribosylamine synthetase activity|ammonia-ribose 5-phosphate aminotransferase activity|ribose 5-phosphate aminotransferase activity|ribose-5-phosphate:ammonia ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0050260 GO:0050261 biolink:MolecularActivity ribose isomerase activity Catalysis of the reaction: ribofuranose = D-ribulose. EC:5.3.1.20|KEGG_REACTION:R01081|MetaCyc:RIBOSE-ISOMERASE-RXN|RHEA:20796 go.json D-ribose aldose-ketose-isomerase activity|D-ribose isomerase activity|D-ribose ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0050261 GO:0050264 biolink:MolecularActivity rifamycin-B oxidase activity Catalysis of the reaction: 2 H+ + O2 + rifamycin B = H2O2 + rifamycin O. EC:1.10.3.6|KEGG_REACTION:R03736|MetaCyc:RIFAMYCIN-B-OXIDASE-RXN|RHEA:11292 go.json rifamycin B oxidase activity|rifamycin-B-oxidase activity|rifamycin-B:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050264 GO:0050265 biolink:MolecularActivity RNA uridylyltransferase activity Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). EC:2.7.7.52|MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN|RHEA:14785|Reactome:R-HSA-8941312 go.json TUT activity|UTP:RNA uridylyltransferase activity|poly(U) polymerase activity|polynucleotide uridylyltransferase activity|terminal uridylyltransferase activity http://purl.obolibrary.org/obo/GO_0050265 GO:0050262 biolink:MolecularActivity ribosylnicotinamide kinase activity Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide. EC:2.7.1.22|KEGG_REACTION:R02324|MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN|RHEA:14017|Reactome:R-HSA-8869627|Reactome:R-HSA-8869633 go.json ATP:N-ribosylnicotinamide 5'-phosphotransferase activity|nicotinamide riboside kinase activity|ribosylnicotinamide kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050262 GO:0050263 biolink:MolecularActivity ribosylpyrimidine nucleosidase activity Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine. EC:3.2.2.8|MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN|RHEA:56816 go.json N-ribosylpyrimidine nucleosidase activity|N-ribosylpyrimidine ribohydrolase activity|RihB|YeiK|nucleoside ribohydrolase activity|pyrimidine nucleosidase activity|pyrimidine-nucleoside ribohydrolase activity http://purl.obolibrary.org/obo/GO_0050263 GO:0050279 biolink:MolecularActivity sepiapterin deaminase activity Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3. EC:3.5.4.24|MetaCyc:SEPIAPTERIN-DEAMINASE-RXN|RHEA:14025 go.json sepiapterin aminohydrolase activity http://purl.obolibrary.org/obo/GO_0050279 GO:0001301 biolink:BiologicalProcess obsolete progressive alteration of chromatin involved in cell aging OBSOLETE. Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. go.json age-dependent accumulation of genetic damage|progressive alteration of chromatin during cell ageing|progressive alteration of chromatin during cell aging True http://purl.obolibrary.org/obo/GO_0001301 GO:0001302 biolink:BiologicalProcess obsolete replicative cell aging OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. go.json replicative cell ageing True http://purl.obolibrary.org/obo/GO_0001302 GO:0001303 biolink:BiologicalProcess obsolete nucleolar fragmentation involved in replicative aging OBSOLETE. A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells. go.json nucleolar fragmentation during replicative ageing|nucleolar fragmentation during replicative aging True http://purl.obolibrary.org/obo/GO_0001303 GO:0050277 biolink:MolecularActivity sedoheptulokinase activity Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate. EC:2.7.1.14|KEGG_REACTION:R01844|MetaCyc:SEDOHEPTULOKINASE-RXN|RHEA:23844|Reactome:R-HSA-8959719 go.json ATP:sedoheptulose 7-phosphotransferase activity|heptulokinase activity|sedoheptulokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050277 GO:0050278 biolink:MolecularActivity sedoheptulose-bisphosphatase activity Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate. EC:3.1.3.37|MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN|RHEA:17461 go.json SBPase activity|sedoheptulose 1,7-bisphosphatase activity|sedoheptulose 1,7-diphosphatase activity|sedoheptulose 1,7-diphosphate phosphatase activity|sedoheptulose bisphosphatase activity|sedoheptulose diphosphatase activity|sedoheptulose-1,7-bisphosphatase activity|sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050278 GO:0001304 biolink:BiologicalProcess obsolete progressive alteration of chromatin involved in replicative cell aging OBSOLETE. A process that results in changes in chromatin structure contributing to replicative cell aging. go.json progressive alteration of chromatin during replicative cell ageing|progressive alteration of chromatin during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001304 GO:0001300 biolink:BiologicalProcess obsolete chronological cell aging OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state. go.json chronological cell ageing True http://purl.obolibrary.org/obo/GO_0001300 GO:1902029 biolink:BiologicalProcess obsolete positive regulation of histone H3-K18 acetylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K18 acetylation. go.json activation of histone H3 acetylation at K18|activation of histone H3-K18 acetylation|activation of histone H3K18 acetylation|positive regulation of histone H3 acetylation at K18|positive regulation of histone H3K18 acetylation|up regulation of histone H3 acetylation at K18|up regulation of histone H3-K18 acetylation|up regulation of histone H3K18 acetylation|up-regulation of histone H3 acetylation at K18|up-regulation of histone H3-K18 acetylation|up-regulation of histone H3K18 acetylation|upregulation of histone H3 acetylation at K18|upregulation of histone H3-K18 acetylation|upregulation of histone H3K18 acetylation True http://purl.obolibrary.org/obo/GO_1902029 GO:1902027 biolink:BiologicalProcess positive regulation of cartilage condensation Any process that activates or increases the frequency, rate or extent of cartilage condensation. go.json activation of cartilage condensation|up regulation of cartilage condensation|up-regulation of cartilage condensation|upregulation of cartilage condensation http://purl.obolibrary.org/obo/GO_1902027 GO:1902028 biolink:BiologicalProcess obsolete regulation of histone H3-K18 acetylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K18 acetylation. go.json regulation of histone H3 acetylation at K18|regulation of histone H3K18 acetylation True http://purl.obolibrary.org/obo/GO_1902028 GO:1902025 biolink:BiologicalProcess nitrate import The directed movement of nitrate into a cell or organelle. go.json nitrate influx|nitrate uptake http://purl.obolibrary.org/obo/GO_1902025 GO:0015946 biolink:BiologicalProcess methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. MetaCyc:CO2FORM-PWY go.json http://purl.obolibrary.org/obo/GO_0015946 GO:0015947 biolink:BiologicalProcess methane metabolic process The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. go.json methane metabolism http://purl.obolibrary.org/obo/GO_0015947 GO:1902026 biolink:BiologicalProcess regulation of cartilage condensation Any process that modulates the frequency, rate or extent of cartilage condensation. go.json http://purl.obolibrary.org/obo/GO_1902026 GO:0015948 biolink:BiologicalProcess methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. UM-BBD_pathwayID:meth|Wikipedia:Methanogenesis go.json methane biosynthesis|methane biosynthetic process http://purl.obolibrary.org/obo/GO_0015948 goslim_metagenomics|goslim_pir GO:1902023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902023 GO:0015949 biolink:BiologicalProcess nucleobase-containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. go.json http://purl.obolibrary.org/obo/GO_0015949 goslim_pir GO:1902024 biolink:BiologicalProcess L-histidine transport The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1902024 GO:1902032 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in response to osmotic stress. go.json global transcription regulation from Pol II promoter involved in osmotic response|global transcription regulation from Pol II promoter involved in osmotic stress response|global transcription regulation from Pol II promoter involved in response to osmotic stress|regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic response|regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic stress response|regulation of gene-specific transcription from RNA polymerase II promoter involved in response to osmotic stress|regulation of global transcription from Pol II promoter involved in osmotic response|regulation of global transcription from Pol II promoter involved in osmotic stress response|regulation of global transcription from Pol II promoter involved in response to osmotic stress|regulation of transcription from Pol II promoter involved in osmotic response|regulation of transcription from Pol II promoter involved in osmotic stress response|regulation of transcription from Pol II promoter involved in response to osmotic stress|regulation of transcription from RNA polymerase II promoter involved in osmotic response|regulation of transcription from RNA polymerase II promoter involved in osmotic stress response|regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress|regulation of transcription from RNA polymerase II promoter, global involved in osmotic response|regulation of transcription from RNA polymerase II promoter, global involved in osmotic stress response|regulation of transcription from RNA polymerase II promoter, global involved in response to osmotic stress True http://purl.obolibrary.org/obo/GO_1902032 GO:0015942 biolink:BiologicalProcess formate metabolic process The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. go.json formate metabolism http://purl.obolibrary.org/obo/GO_0015942 GO:0015943 biolink:BiologicalProcess formate biosynthetic process The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. go.json formate anabolism|formate biosynthesis|formate formation|formate synthesis|formic acid biosynthesis|formic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0015943 GO:1902033 biolink:BiologicalProcess regulation of hematopoietic stem cell proliferation Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. go.json regulation of hemopoietic stem cell proliferation http://purl.obolibrary.org/obo/GO_1902033 GO:0015944 biolink:BiologicalProcess formate oxidation The chemical reactions and pathways by which formate is converted to CO2. MetaCyc:PWY-1881 go.json formic acid oxidation http://purl.obolibrary.org/obo/GO_0015944 GO:1902030 biolink:BiologicalProcess obsolete negative regulation of histone H3-K18 acetylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K18 acetylation. go.json down regulation of histone H3 acetylation at K18|down regulation of histone H3-K18 acetylation|down regulation of histone H3K18 acetylation|down-regulation of histone H3 acetylation at K18|down-regulation of histone H3-K18 acetylation|down-regulation of histone H3K18 acetylation|downregulation of histone H3 acetylation at K18|downregulation of histone H3-K18 acetylation|downregulation of histone H3K18 acetylation|inhibition of histone H3 acetylation at K18|inhibition of histone H3-K18 acetylation|inhibition of histone H3K18 acetylation|negative regulation of histone H3 acetylation at K18|negative regulation of histone H3K18 acetylation True http://purl.obolibrary.org/obo/GO_1902030 GO:1902031 biolink:BiologicalProcess regulation of NADP metabolic process Any process that modulates the frequency, rate or extent of NADP metabolic process. go.json regulation of NAD phosphorylation and dephosphorylation|regulation of NADP (oxidized) metabolic process|regulation of NADP (oxidized) metabolism|regulation of NADP (reduced) metabolic process|regulation of NADP (reduced) metabolism|regulation of NADP metabolism|regulation of NADPH metabolic process|regulation of NADPH metabolism|regulation of nicotinamide adenine dinucleotide phosphate metabolic process|regulation of nicotinamide adenine dinucleotide phosphate metabolism|regulation of oxidized NADP metabolic process|regulation of oxidized NADP metabolism|regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolic process|regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolism|regulation of reduced NADP metabolic process|regulation of reduced NADP metabolism|regulation of reduced nicotinamide adenine dinucleotide phosphate metabolic process|regulation of reduced nicotinamide adenine dinucleotide phosphate metabolism http://purl.obolibrary.org/obo/GO_1902031 GO:0015945 biolink:BiologicalProcess methanol metabolic process The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. go.json methanol metabolism http://purl.obolibrary.org/obo/GO_0015945 GO:0015940 biolink:BiologicalProcess pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. MetaCyc:PANTO-PWY|MetaCyc:PANTOSYN-PWY|MetaCyc:PWY-3961|MetaCyc:PWY-4221 go.json pantothenate anabolism|pantothenate anabolism from 2-oxypantoyl lactone|pantothenate anabolism from valine|pantothenate biosynthesis|pantothenate biosynthesis from 2-oxypantoyl lactone|pantothenate biosynthesis from valine|pantothenate biosynthetic process from 2-dehydropantolactone|pantothenate biosynthetic process from 2-oxypantoyl lactone|pantothenate biosynthetic process from valine|pantothenate formation|pantothenate formation from 2-oxypantoyl lactone|pantothenate formation from valine|pantothenate synthesis|pantothenate synthesis from 2-oxypantoyl lactone|pantothenate synthesis from valine|vitamin B5 biosynthesis|vitamin B5 biosynthetic process http://purl.obolibrary.org/obo/GO_0015940 GO:0015941 biolink:BiologicalProcess pantothenate catabolic process The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. go.json pantothenate breakdown|pantothenate catabolism|pantothenate degradation|vitamin B5 catabolic process|vitamin B5 catabolism http://purl.obolibrary.org/obo/GO_0015941 GO:0050271 biolink:MolecularActivity S-alkylcysteine lyase activity Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate. EC:4.4.1.6|MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN|RHEA:22424 go.json S-alkyl-L-cysteinase activity|S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity|S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)|S-alkyl-L-cysteine lyase activity|S-alkyl-L-cysteine sulfoxide lyase activity|S-alkylcysteinase activity|alkyl cysteine lyase activity|alkylcysteine lyase activity http://purl.obolibrary.org/obo/GO_0050271 GO:0001309 biolink:BiologicalProcess obsolete age-dependent telomere shortening OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process. go.json age-dependent telomere shortening True http://purl.obolibrary.org/obo/GO_0001309 GO:0050272 biolink:MolecularActivity S-carboxymethylcysteine synthase activity Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+. EC:4.5.1.5|KEGG_REACTION:R04003|MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN|RHEA:22868 go.json 3-chloro-L-alanine chloride-lyase (adding thioglycolate)|3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)|S-carboxymethyl-L-cysteine synthase activity http://purl.obolibrary.org/obo/GO_0050272 GO:0050270 biolink:MolecularActivity S-adenosylhomocysteine deaminase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4. EC:3.5.4.28|KEGG_REACTION:R00193|MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN|RHEA:20716 go.json S-adenosyl-L-homocysteine aminohydrolase activity|adenosylhomocysteine deaminase activity http://purl.obolibrary.org/obo/GO_0050270 GO:0001305 biolink:BiologicalProcess obsolete progressive alteration of chromatin involved in chronological cell aging OBSOLETE. A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells. go.json progressive alteration of chromatin during chronological cell ageing|progressive alteration of chromatin during chronological cell aging True http://purl.obolibrary.org/obo/GO_0001305 GO:0050275 biolink:MolecularActivity scopoletin glucosyltransferase activity Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP. EC:2.4.1.128|KEGG_REACTION:R03594|MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN|RHEA:20453 go.json SGTase activity|UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity|UDPglucose:scopoletin O-beta-D-glucosyltransferase activity|UDPglucose:scopoletin glucosyltransferase activity|uridine diphosphoglucose-scopoletin glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050275 GO:0001306 biolink:BiologicalProcess obsolete age-dependent response to oxidative stress OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism. go.json True http://purl.obolibrary.org/obo/GO_0001306 GO:0050276 biolink:MolecularActivity scyllo-inosamine 4-kinase activity Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H+. EC:2.7.1.65|KEGG_REACTION:R03384|MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN|RHEA:18605 go.json ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity|ATP:inosamine phosphotransferase activity|scyllo-inosamine kinase (phosphorylating)|scyllo-inosamine kinase activity http://purl.obolibrary.org/obo/GO_0050276 GO:0050273 biolink:MolecularActivity S-succinylglutathione hydrolase activity Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate. EC:3.1.2.13|KEGG_REACTION:R00499|MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN|RHEA:16713 go.json http://purl.obolibrary.org/obo/GO_0050273 GO:0001307 biolink:BiologicalProcess obsolete extrachromosomal circular DNA accumulation involved in replicative cell aging OBSOLETE. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. go.json extrachromosomal circular DNA accumulation during replicative cell ageing|extrachromosomal circular DNA accumulation during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001307 GO:0050274 biolink:MolecularActivity salicyl-alcohol beta-D-glucosyltransferase activity Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H+ + salicin + UDP. EC:2.4.1.172|KEGG_REACTION:R03558|MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN|RHEA:11512 go.json UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity|UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity|UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity|salicyl-alcohol b-D-glucosyltransferase activity|salicyl-alcohol glucosyltransferase activity|uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050274 GO:0001308 biolink:BiologicalProcess obsolete negative regulation of chromatin silencing involved in replicative cell aging OBSOLETE. The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins. go.json loss of chromatin silencing during replicative cell ageing|loss of chromatin silencing involved in replicative cell aging True http://purl.obolibrary.org/obo/GO_0001308 GO:0050288 biolink:MolecularActivity sorbose dehydrogenase activity Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2). EC:1.1.99.12|KEGG_REACTION:R01696|MetaCyc:SORBOSE-DEHYDROGENASE-RXN|RHEA:14713 go.json L-sorbose:(acceptor) 5-oxidoreductase activity|L-sorbose:acceptor 5-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050288 GO:0050289 biolink:MolecularActivity spermidine dehydrogenase activity Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor. EC:1.5.99.6|MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN|RHEA:14273 go.json spermidine:(acceptor) oxidoreductase activity|spermidine:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050289 GO:0015917 biolink:BiologicalProcess aminophospholipid transport The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. go.json http://purl.obolibrary.org/obo/GO_0015917 GO:0015918 biolink:BiologicalProcess sterol transport The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json http://purl.obolibrary.org/obo/GO_0015918 GO:1902038 biolink:BiologicalProcess positive regulation of hematopoietic stem cell differentiation Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. go.json activation of haematopoietic stem cell differentiation|activation of haemopoietic stem cell differentiation|activation of hematopoietic stem cell differentiation|activation of hemopoietic stem cell differentiation|positive regulation of haematopoietic stem cell differentiation|positive regulation of haemopoietic stem cell differentiation|positive regulation of hemopoietic stem cell differentiation|up regulation of haematopoietic stem cell differentiation|up regulation of haemopoietic stem cell differentiation|up regulation of hematopoietic stem cell differentiation|up regulation of hemopoietic stem cell differentiation|up-regulation of haematopoietic stem cell differentiation|up-regulation of haemopoietic stem cell differentiation|up-regulation of hematopoietic stem cell differentiation|up-regulation of hemopoietic stem cell differentiation|upregulation of haematopoietic stem cell differentiation|upregulation of haemopoietic stem cell differentiation|upregulation of hematopoietic stem cell differentiation|upregulation of hemopoietic stem cell differentiation http://purl.obolibrary.org/obo/GO_1902038 GO:0015919 biolink:BiologicalProcess peroxisomal membrane transport The directed movement of substances to, from or across the peroxisomal membrane. go.json http://purl.obolibrary.org/obo/GO_0015919 GO:1902039 biolink:BiologicalProcess negative regulation of seed dormancy process Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process. go.json down regulation of seed dormancy|down regulation of seed dormancy process|down-regulation of seed dormancy|down-regulation of seed dormancy process|downregulation of seed dormancy|downregulation of seed dormancy process|inhibition of seed dormancy|inhibition of seed dormancy process|negative regulation of seed dormancy http://purl.obolibrary.org/obo/GO_1902039 GO:0015913 biolink:BiologicalProcess short-chain fatty acid transmembrane transport The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons. go.json short-chain fatty acid import|short-chain fatty acid uptake http://purl.obolibrary.org/obo/GO_0015913 GO:1902036 biolink:BiologicalProcess regulation of hematopoietic stem cell differentiation Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. go.json regulation of haematopoietic stem cell differentiation|regulation of haemopoietic stem cell differentiation|regulation of hemopoietic stem cell differentiation http://purl.obolibrary.org/obo/GO_1902036 GO:1902037 biolink:BiologicalProcess negative regulation of hematopoietic stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. go.json down regulation of haematopoietic stem cell differentiation|down regulation of haemopoietic stem cell differentiation|down regulation of hematopoietic stem cell differentiation|down regulation of hemopoietic stem cell differentiation|down-regulation of haematopoietic stem cell differentiation|down-regulation of haemopoietic stem cell differentiation|down-regulation of hematopoietic stem cell differentiation|down-regulation of hemopoietic stem cell differentiation|downregulation of haematopoietic stem cell differentiation|downregulation of haemopoietic stem cell differentiation|downregulation of hematopoietic stem cell differentiation|downregulation of hemopoietic stem cell differentiation|inhibition of haematopoietic stem cell differentiation|inhibition of haemopoietic stem cell differentiation|inhibition of hematopoietic stem cell differentiation|inhibition of hemopoietic stem cell differentiation|negative regulation of haematopoietic stem cell differentiation|negative regulation of haemopoietic stem cell differentiation|negative regulation of hemopoietic stem cell differentiation http://purl.obolibrary.org/obo/GO_1902037 GO:0015914 biolink:BiologicalProcess phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. go.json http://purl.obolibrary.org/obo/GO_0015914 GO:1902034 biolink:BiologicalProcess negative regulation of hematopoietic stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. go.json down regulation of hematopoietic stem cell proliferation|down regulation of hemopoietic stem cell proliferation|down-regulation of hematopoietic stem cell proliferation|down-regulation of hemopoietic stem cell proliferation|downregulation of hematopoietic stem cell proliferation|downregulation of hemopoietic stem cell proliferation|inhibition of hematopoietic stem cell proliferation|inhibition of hemopoietic stem cell proliferation|negative regulation of hemopoietic stem cell proliferation http://purl.obolibrary.org/obo/GO_1902034 GO:0015915 biolink:BiologicalProcess obsolete fatty-acyl group transport OBSOLETE. The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid. go.json fatty acyl transport True http://purl.obolibrary.org/obo/GO_0015915 GO:0015916 biolink:BiologicalProcess fatty-acyl-CoA transport The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A). go.json fatty acyl CoA transport|fatty acyl coenzyme A transport|fatty acyl-CoA transport http://purl.obolibrary.org/obo/GO_0015916 GO:1902035 biolink:BiologicalProcess positive regulation of hematopoietic stem cell proliferation Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. go.json activation of hematopoietic stem cell proliferation|activation of hemopoietic stem cell proliferation|positive regulation of hemopoietic stem cell proliferation|up regulation of hematopoietic stem cell proliferation|up regulation of hemopoietic stem cell proliferation|up-regulation of hematopoietic stem cell proliferation|up-regulation of hemopoietic stem cell proliferation|upregulation of hematopoietic stem cell proliferation|upregulation of hemopoietic stem cell proliferation http://purl.obolibrary.org/obo/GO_1902035 GO:1902043 biolink:BiologicalProcess positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. go.json activation of death receptor-mediated apoptosis|activation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of death receptor-mediated apoptosis|up regulation of death receptor-mediated apoptosis|up regulation of extrinsic apoptotic signaling pathway via death domain receptors|up-regulation of death receptor-mediated apoptosis|up-regulation of extrinsic apoptotic signaling pathway via death domain receptors|upregulation of death receptor-mediated apoptosis|upregulation of extrinsic apoptotic signaling pathway via death domain receptors http://purl.obolibrary.org/obo/GO_1902043 GO:1902044 biolink:BiologicalProcess regulation of Fas signaling pathway Any process that modulates the frequency, rate or extent of Fas signaling pathway. go.json regulation of Apo-1 signaling pathway|regulation of CD95 signaling pathway|regulation of FAS ligand-Fas signaling pathway|regulation of Fas receptor signaling pathway|regulation of Fas-FasL signaling pathway|regulation of FasL signaling pathway|regulation of FasR signaling pathway http://purl.obolibrary.org/obo/GO_1902044 GO:0015910 biolink:BiologicalProcess long-chain fatty acid import into peroxisome The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json peroxisomal long-chain fatty acid import|peroxisomal long-chain fatty acid uptake http://purl.obolibrary.org/obo/GO_0015910 GO:0015911 biolink:BiologicalProcess long-chain fatty acid import across plasma membrane The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json plasma membrane long-chain fatty acid transport http://purl.obolibrary.org/obo/GO_0015911 GO:1902041 biolink:BiologicalProcess regulation of extrinsic apoptotic signaling pathway via death domain receptors Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. go.json regulation of death receptor-mediated apoptosis http://purl.obolibrary.org/obo/GO_1902041 GO:1902042 biolink:BiologicalProcess negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. go.json down regulation of death receptor-mediated apoptosis|down regulation of extrinsic apoptotic signaling pathway via death domain receptors|down-regulation of death receptor-mediated apoptosis|down-regulation of extrinsic apoptotic signaling pathway via death domain receptors|downregulation of death receptor-mediated apoptosis|downregulation of extrinsic apoptotic signaling pathway via death domain receptors|inhibition of death receptor-mediated apoptosis|inhibition of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of death receptor-mediated apoptosis http://purl.obolibrary.org/obo/GO_1902042 GO:0015912 biolink:BiologicalProcess short-chain fatty acid transport The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons. go.json http://purl.obolibrary.org/obo/GO_0015912 GO:1902040 biolink:BiologicalProcess positive regulation of seed dormancy process Any process that activates or increases the frequency, rate or extent of seed dormancy process. go.json activation of seed dormancy|activation of seed dormancy process|positive regulation of seed dormancy|up regulation of seed dormancy|up regulation of seed dormancy process|up-regulation of seed dormancy|up-regulation of seed dormancy process|upregulation of seed dormancy|upregulation of seed dormancy process http://purl.obolibrary.org/obo/GO_1902040 GO:0050282 biolink:MolecularActivity serine 2-dehydrogenase activity Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH. EC:1.4.1.7|MetaCyc:SERINE-DEHYDROGENASE-RXN|RHEA:20884 go.json L-serine:NAD oxidoreductase (deaminating) activity|L-serine:NAD+ 2-oxidoreductase (deaminating)|serine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050282 GO:0050283 biolink:MolecularActivity serine-sulfate ammonia-lyase activity Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate. EC:4.3.1.10|MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN|RHEA:15605 go.json (L-SOS)lyase activity|L-serine-O-sulfate ammonia-lyase (pyruvate-forming)|serine-sulphate ammonia-lyase activity http://purl.obolibrary.org/obo/GO_0050283 GO:0050280 biolink:MolecularActivity sequoyitol dehydrogenase activity Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADH. EC:1.1.1.143|KEGG_REACTION:R03497|MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN|RHEA:11300 go.json 5-O-methyl-myo-inositol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050280 GO:0050281 biolink:MolecularActivity serine-glyoxylate transaminase activity Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine. EC:2.6.1.45|MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN|RHEA:19125 go.json L-serine:glyoxylate aminotransferase activity|SGAT activity|serine--glyoxylate aminotransferase activity http://purl.obolibrary.org/obo/GO_0050281 GO:0050286 biolink:MolecularActivity sorbitol-6-phosphatase activity Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate. EC:3.1.3.50|KEGG_REACTION:R02866|MetaCyc:SORBITOL-6-PHOSPHATASE-RXN|RHEA:24580 go.json sorbitol-6-phosphate phosphatase activity|sorbitol-6-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050286 GO:0050287 biolink:MolecularActivity sorbose 5-dehydrogenase (NADP+) activity Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH. EC:1.1.1.123|KEGG_REACTION:R01694|MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN|RHEA:15001 go.json 5-keto-D-fructose reductase activity|5-ketofructose reductase activity|L-sorbose:NADP+ 5-oxidoreductase activity|reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity|sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050287 GO:0050284 biolink:MolecularActivity sinapate 1-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose. EC:2.4.1.120|MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN|RHEA:13305 go.json UDP-glucose:sinapate D-glucosyltransferase activity|UDPglucose:sinapate D-glucosyltransferase activity|UDPglucose:sinapic acid glucosyltransferase activity|uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity|uridine diphosphoglucose-sinapate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050284 GO:0050285 biolink:MolecularActivity sinapine esterase activity Catalysis of the reaction: O-sinapoylcholine + H2O = choline + H+ + sinapate. EC:3.1.1.49|KEGG_REACTION:R02381|MetaCyc:SINAPINE-ESTERASE-RXN|RHEA:10016 go.json aromatic choline esterase activity|sinapoylcholine sinapohydrolase activity http://purl.obolibrary.org/obo/GO_0050285 GO:0050299 biolink:MolecularActivity streptomycin 3''-kinase activity Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate. EC:2.7.1.87|KEGG_REACTION:R02227|MetaCyc:STREPTOMYCIN-3-KINASE-RXN|RHEA:18377 go.json ATP:streptomycin 3''-phosphotransferase activity|streptomycin 3''-kinase (phosphorylating)|streptomycin 3''-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050299 GO:0015928 biolink:MolecularActivity fucosidase activity Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. go.json http://purl.obolibrary.org/obo/GO_0015928 GO:0015929 biolink:MolecularActivity hexosaminidase activity Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. MetaCyc:3.2.1.52-RXN go.json http://purl.obolibrary.org/obo/GO_0015929 GO:1902049 biolink:BiologicalProcess neosartoricin catabolic process The chemical reactions and pathways resulting in the breakdown of neosartoricin. go.json neosartoricin breakdown|neosartoricin catabolism|neosartoricin degradation http://purl.obolibrary.org/obo/GO_1902049 GO:1902047 biolink:BiologicalProcess polyamine transmembrane transport The process in which a polyamine macromolecule is transported across a membrane. go.json polyamine import|polyamine uptake http://purl.obolibrary.org/obo/GO_1902047 GO:0015924 biolink:MolecularActivity mannosyl-oligosaccharide mannosidase activity Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. go.json http://purl.obolibrary.org/obo/GO_0015924 GO:1902048 biolink:BiologicalProcess neosartoricin metabolic process The chemical reactions and pathways involving neosartoricin. go.json neosartoricin metabolism http://purl.obolibrary.org/obo/GO_1902048 GO:0015925 biolink:MolecularActivity galactosidase activity Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. go.json http://purl.obolibrary.org/obo/GO_0015925 GO:1902045 biolink:BiologicalProcess negative regulation of Fas signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway. go.json down regulation of Apo-1 signaling pathway|down regulation of CD95 signaling pathway|down regulation of FAS ligand-Fas signaling pathway|down regulation of Fas receptor signaling pathway|down regulation of Fas signaling pathway|down regulation of Fas-FasL signaling pathway|down regulation of FasL signaling pathway|down regulation of FasR signaling pathway|down-regulation of Apo-1 signaling pathway|down-regulation of CD95 signaling pathway|down-regulation of FAS ligand-Fas signaling pathway|down-regulation of Fas receptor signaling pathway|down-regulation of Fas signaling pathway|down-regulation of Fas-FasL signaling pathway|down-regulation of FasL signaling pathway|down-regulation of FasR signaling pathway|downregulation of Apo-1 signaling pathway|downregulation of CD95 signaling pathway|downregulation of FAS ligand-Fas signaling pathway|downregulation of Fas receptor signaling pathway|downregulation of Fas signaling pathway|downregulation of Fas-FasL signaling pathway|downregulation of FasL signaling pathway|downregulation of FasR signaling pathway|inhibition of Apo-1 signaling pathway|inhibition of CD95 signaling pathway|inhibition of FAS ligand-Fas signaling pathway|inhibition of Fas receptor signaling pathway|inhibition of Fas signaling pathway|inhibition of Fas-FasL signaling pathway|inhibition of FasL signaling pathway|inhibition of FasR signaling pathway|negative regulation of Apo-1 signaling pathway|negative regulation of CD95 signaling pathway|negative regulation of FAS ligand-Fas signaling pathway|negative regulation of Fas receptor signaling pathway|negative regulation of Fas-FasL signaling pathway|negative regulation of FasL signaling pathway|negative regulation of FasR signaling pathway http://purl.obolibrary.org/obo/GO_1902045 GO:0015926 biolink:MolecularActivity glucosidase activity Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. go.json http://purl.obolibrary.org/obo/GO_0015926 GO:1902046 biolink:BiologicalProcess positive regulation of Fas signaling pathway Any process that activates or increases the frequency, rate or extent of Fas signaling pathway. go.json activation of Apo-1 signaling pathway|activation of CD95 signaling pathway|activation of FAS ligand-Fas signaling pathway|activation of Fas receptor signaling pathway|activation of Fas signaling pathway|activation of Fas-FasL signaling pathway|activation of FasL signaling pathway|activation of FasR signaling pathway|positive regulation of Apo-1 signaling pathway|positive regulation of CD95 signaling pathway|positive regulation of FAS ligand-Fas signaling pathway|positive regulation of Fas receptor signaling pathway|positive regulation of Fas-FasL signaling pathway|positive regulation of FasL signaling pathway|positive regulation of FasR signaling pathway|up regulation of Apo-1 signaling pathway|up regulation of CD95 signaling pathway|up regulation of FAS ligand-Fas signaling pathway|up regulation of Fas receptor signaling pathway|up regulation of Fas signaling pathway|up regulation of Fas-FasL signaling pathway|up regulation of FasL signaling pathway|up regulation of FasR signaling pathway|up-regulation of Apo-1 signaling pathway|up-regulation of CD95 signaling pathway|up-regulation of FAS ligand-Fas signaling pathway|up-regulation of Fas receptor signaling pathway|up-regulation of Fas signaling pathway|up-regulation of Fas-FasL signaling pathway|up-regulation of FasL signaling pathway|up-regulation of FasR signaling pathway|upregulation of Apo-1 signaling pathway|upregulation of CD95 signaling pathway|upregulation of FAS ligand-Fas signaling pathway|upregulation of Fas receptor signaling pathway|upregulation of Fas signaling pathway|upregulation of Fas-FasL signaling pathway|upregulation of FasL signaling pathway|upregulation of FasR signaling pathway http://purl.obolibrary.org/obo/GO_1902046 GO:0015927 biolink:MolecularActivity trehalase activity Catalysis of the hydrolysis of trehalose or a trehalose derivative. MetaCyc:TREHALA-RXN go.json http://purl.obolibrary.org/obo/GO_0015927 GO:0015920 biolink:BiologicalProcess lipopolysaccharide transport The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. go.json LPS export|LPS transport|lipopolysaccharide export http://purl.obolibrary.org/obo/GO_0015920 goslim_pir GO:1902054 biolink:BiologicalProcess negative regulation of neosartoricin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process. go.json down regulation of neosartoricin anabolism|down regulation of neosartoricin biosynthesis|down regulation of neosartoricin biosynthetic process|down regulation of neosartoricin formation|down regulation of neosartoricin synthesis|down-regulation of neosartoricin anabolism|down-regulation of neosartoricin biosynthesis|down-regulation of neosartoricin biosynthetic process|down-regulation of neosartoricin formation|down-regulation of neosartoricin synthesis|downregulation of neosartoricin anabolism|downregulation of neosartoricin biosynthesis|downregulation of neosartoricin biosynthetic process|downregulation of neosartoricin formation|downregulation of neosartoricin synthesis|inhibition of neosartoricin anabolism|inhibition of neosartoricin biosynthesis|inhibition of neosartoricin biosynthetic process|inhibition of neosartoricin formation|inhibition of neosartoricin synthesis|negative regulation of neosartoricin anabolism|negative regulation of neosartoricin biosynthesis|negative regulation of neosartoricin formation|negative regulation of neosartoricin synthesis http://purl.obolibrary.org/obo/GO_1902054 GO:0015921 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015921 GO:1902055 biolink:BiologicalProcess positive regulation of neosartoricin biosynthetic process Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process. go.json activation of neosartoricin anabolism|activation of neosartoricin biosynthesis|activation of neosartoricin biosynthetic process|activation of neosartoricin formation|activation of neosartoricin synthesis|positive regulation of neosartoricin anabolism|positive regulation of neosartoricin biosynthesis|positive regulation of neosartoricin formation|positive regulation of neosartoricin synthesis|up regulation of neosartoricin anabolism|up regulation of neosartoricin biosynthesis|up regulation of neosartoricin biosynthetic process|up regulation of neosartoricin formation|up regulation of neosartoricin synthesis|up-regulation of neosartoricin anabolism|up-regulation of neosartoricin biosynthesis|up-regulation of neosartoricin biosynthetic process|up-regulation of neosartoricin formation|up-regulation of neosartoricin synthesis|upregulation of neosartoricin anabolism|upregulation of neosartoricin biosynthesis|upregulation of neosartoricin biosynthetic process|upregulation of neosartoricin formation|upregulation of neosartoricin synthesis http://purl.obolibrary.org/obo/GO_1902055 GO:0015922 biolink:MolecularActivity obsolete aspartate oxidase activity OBSOLETE. Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide. go.json True http://purl.obolibrary.org/obo/GO_0015922 GO:1902052 biolink:MolecularActivity (25S)-Delta(7)-dafachronate binding Binding to (25S)-Delta(7)-dafachronate. go.json http://purl.obolibrary.org/obo/GO_1902052 GO:1902053 biolink:BiologicalProcess regulation of neosartoricin biosynthetic process Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process. go.json regulation of neosartoricin anabolism|regulation of neosartoricin biosynthesis|regulation of neosartoricin formation|regulation of neosartoricin synthesis http://purl.obolibrary.org/obo/GO_1902053 GO:0015923 biolink:MolecularActivity mannosidase activity Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. go.json http://purl.obolibrary.org/obo/GO_0015923 GO:1902050 biolink:BiologicalProcess neosartoricin biosynthetic process The chemical reactions and pathways resulting in the formation of neosartoricin. go.json neosartoricin anabolism|neosartoricin biosynthesis|neosartoricin formation|neosartoricin synthesis http://purl.obolibrary.org/obo/GO_1902050 GO:0050290 biolink:MolecularActivity sphingomyelin phosphodiesterase D activity Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+. EC:3.1.4.41|KEGG_REACTION:R02542|MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN|RHEA:20984 go.json sphingomyelin ceramide-phosphohydrolase activity|sphingomyelinase D http://purl.obolibrary.org/obo/GO_0050290 GO:1902051 biolink:MolecularActivity (25S)-Delta(4)-dafachronate binding Binding to (25S)-Delta(4)-dafachronate. go.json http://purl.obolibrary.org/obo/GO_1902051 GO:0050293 biolink:MolecularActivity steroid-lactonase activity Catalysis of the reaction: H2O + testololactone = H+ + testolate. EC:3.1.1.37|KEGG_REACTION:R03641|MetaCyc:STEROID-LACTONASE-RXN|RHEA:13721 go.json testololactone lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0050293 GO:0050294 biolink:MolecularActivity steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. EC:2.8.2.15|MetaCyc:STEROID-SULFOTRANSFERASE-RXN|RHEA:68460|Reactome:R-HSA-176517|Reactome:R-HSA-176521|Reactome:R-HSA-176631 go.json 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity|steroid alcohol sulfotransferase|steroid sulphotransferase activity http://purl.obolibrary.org/obo/GO_0050294 goslim_chembl GO:0050291 biolink:MolecularActivity sphingosine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. EC:2.3.1.24|MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN|RHEA:23768|Reactome:R-HSA-428185 go.json acyl-CoA:sphingosine N-acyltransferase activity|ceramide synthase activity|ceramide synthetase activity|dihydroceramide synthase activity|sphingosine acyltransferase activity http://purl.obolibrary.org/obo/GO_0050291 GO:0050292 biolink:MolecularActivity steroid 9-alpha-monooxygenase activity Catalysis of the reaction: AH(2) + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O. EC:1.14.99.24|KEGG_REACTION:R04392|MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN|RHEA:19557 go.json steroid 9-alpha-hydroxylase activity|steroid 9a-monooxygenase activity|steroid 9alpha-hydroxylase activity|steroid 9alpha-monooxygenase activity|steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing) http://purl.obolibrary.org/obo/GO_0050292 GO:0050297 biolink:MolecularActivity stizolobate synthase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. EC:1.13.11.29|MetaCyc:RXN-8460|RHEA:21220 go.json 3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing) http://purl.obolibrary.org/obo/GO_0050297 GO:0050298 biolink:MolecularActivity stizolobinate synthase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. EC:1.13.11.30|MetaCyc:STIZOLOBINATE-SYNTHASE-RXN|RHEA:18465 go.json 3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing) http://purl.obolibrary.org/obo/GO_0050298 GO:0050295 biolink:MolecularActivity steryl-beta-glucosidase activity Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol. EC:3.2.1.104|KEGG_REACTION:R01460|MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN|RHEA:11956 go.json cholesteryl-beta-D-glucoside glucohydrolase activity|steryl-b-glucosidase activity http://purl.obolibrary.org/obo/GO_0050295 GO:0050296 biolink:MolecularActivity stipitatonate decarboxylase activity Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate. EC:4.1.1.60|KEGG_REACTION:R03739|MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN|RHEA:13885 go.json stipitatonate carboxy-lyase (decyclizing)|stipitatonate carboxy-lyase (decyclizing, stipitatate-forming) http://purl.obolibrary.org/obo/GO_0050296 GO:1902058 biolink:BiologicalProcess regulation of sporocarp development involved in sexual reproduction Any process that modulates the frequency, rate or extent of sporocarp development involved in sexual reproduction. go.json regulation of ascus development|regulation of fruiting body development involved in sexual reproduction|regulation of fruiting body formation involved in sexual reproduction|regulation of perfect stage fruiting body development http://purl.obolibrary.org/obo/GO_1902058 GO:1902059 biolink:BiologicalProcess negative regulation of sporocarp development involved in sexual reproduction Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction. go.json down regulation of ascus development|down regulation of fruiting body development involved in sexual reproduction|down regulation of fruiting body formation involved in sexual reproduction|down regulation of perfect stage fruiting body development|down regulation of sporocarp development involved in sexual reproduction|down-regulation of ascus development|down-regulation of fruiting body development involved in sexual reproduction|down-regulation of fruiting body formation involved in sexual reproduction|down-regulation of perfect stage fruiting body development|down-regulation of sporocarp development involved in sexual reproduction|downregulation of ascus development|downregulation of fruiting body development involved in sexual reproduction|downregulation of fruiting body formation involved in sexual reproduction|downregulation of perfect stage fruiting body development|downregulation of sporocarp development involved in sexual reproduction|inhibition of ascus development|inhibition of fruiting body development involved in sexual reproduction|inhibition of fruiting body formation involved in sexual reproduction|inhibition of perfect stage fruiting body development|inhibition of sporocarp development involved in sexual reproduction|negative regulation of ascus development|negative regulation of fruiting body development involved in sexual reproduction|negative regulation of fruiting body formation involved in sexual reproduction|negative regulation of perfect stage fruiting body development http://purl.obolibrary.org/obo/GO_1902059 GO:1902056 biolink:BiologicalProcess (25S)-Delta(7)-dafachronate metabolic process The chemical reactions and pathways involving (25S)-Delta(7)-dafachronate. go.json (25S)-Delta(7)-dafachronate metabolism http://purl.obolibrary.org/obo/GO_1902056 GO:1902057 biolink:BiologicalProcess (25S)-Delta(4)-dafachronate metabolic process The chemical reactions and pathways involving (25S)-Delta(4)-dafachronate. go.json (25S)-Delta(4)-dafachronate metabolism http://purl.obolibrary.org/obo/GO_1902057 GO:1902065 biolink:BiologicalProcess response to L-glutamate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus. go.json http://purl.obolibrary.org/obo/GO_1902065 GO:1902066 biolink:BiologicalProcess regulation of cell wall pectin metabolic process Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process. go.json regulation of cell wall pectin metabolism|regulation of cellulose and pectin-containing cell wall pectin metabolic process|regulation of pectin metabolism during cell wall biogenesis|regulation of plant-type cell wall pectin metabolic process http://purl.obolibrary.org/obo/GO_1902066 GO:1902063 biolink:BiologicalProcess betaine aldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of betaine aldehyde. go.json betaine aldehyde anabolism|betaine aldehyde biosynthesis|betaine aldehyde formation|betaine aldehyde synthesis http://purl.obolibrary.org/obo/GO_1902063 GO:1902064 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in spermatogenesis OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis. go.json global transcription regulation from Pol II promoter involved in generation of spermatozoa|global transcription regulation from Pol II promoter involved in spermatogenesis|regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa|regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis|regulation of global transcription from Pol II promoter involved in generation of spermatozoa|regulation of global transcription from Pol II promoter involved in spermatogenesis|regulation of transcription from Pol II promoter involved in generation of spermatozoa|regulation of transcription from Pol II promoter involved in spermatogenesis|regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa|regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa|regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis True http://purl.obolibrary.org/obo/GO_1902064 GO:1902061 biolink:BiologicalProcess betaine aldehyde metabolic process The chemical reactions and pathways involving betaine aldehyde. go.json betaine aldehyde metabolism http://purl.obolibrary.org/obo/GO_1902061 GO:1902062 biolink:BiologicalProcess betaine aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of betaine aldehyde. go.json betaine aldehyde breakdown|betaine aldehyde catabolism|betaine aldehyde degradation http://purl.obolibrary.org/obo/GO_1902062 GO:1902060 biolink:BiologicalProcess positive regulation of sporocarp development involved in sexual reproduction Any process that activates or increases the frequency, rate or extent of sporocarp development involved in sexual reproduction. go.json activation of ascus development|activation of fruiting body development involved in sexual reproduction|activation of fruiting body formation involved in sexual reproduction|activation of perfect stage fruiting body development|activation of sporocarp development involved in sexual reproduction|positive regulation of ascus development|positive regulation of fruiting body development involved in sexual reproduction|positive regulation of fruiting body formation involved in sexual reproduction|positive regulation of perfect stage fruiting body development|up regulation of ascus development|up regulation of fruiting body development involved in sexual reproduction|up regulation of fruiting body formation involved in sexual reproduction|up regulation of perfect stage fruiting body development|up regulation of sporocarp development involved in sexual reproduction|up-regulation of ascus development|up-regulation of fruiting body development involved in sexual reproduction|up-regulation of fruiting body formation involved in sexual reproduction|up-regulation of perfect stage fruiting body development|up-regulation of sporocarp development involved in sexual reproduction|upregulation of ascus development|upregulation of fruiting body development involved in sexual reproduction|upregulation of fruiting body formation involved in sexual reproduction|upregulation of perfect stage fruiting body development|upregulation of sporocarp development involved in sexual reproduction http://purl.obolibrary.org/obo/GO_1902060 GO:0015906 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015906 GO:0015907 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015907 GO:0015908 biolink:BiologicalProcess fatty acid transport The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0015908 GO:0015909 biolink:BiologicalProcess long-chain fatty acid transport The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json http://purl.obolibrary.org/obo/GO_0015909 GO:1902069 biolink:BiologicalProcess negative regulation of sphingolipid mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of sphingolipid signaling. go.json down regulation of sphingolipid mediated signaling pathway|down regulation of sphingolipid signaling pathway|down-regulation of sphingolipid mediated signaling pathway|down-regulation of sphingolipid signaling pathway|downregulation of sphingolipid mediated signaling pathway|downregulation of sphingolipid signaling pathway|inhibition of sphingolipid mediated signaling pathway|inhibition of sphingolipid signaling pathway|negative regulation of sphingolipid signaling pathway http://purl.obolibrary.org/obo/GO_1902069 GO:0015902 biolink:BiologicalProcess obsolete carbonyl cyanide m-chlorophenylhydrazone transport OBSOLETE. The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. go.json CCCP transport True http://purl.obolibrary.org/obo/GO_0015902 GO:0015903 biolink:BiologicalProcess fluconazole transport The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. go.json http://purl.obolibrary.org/obo/GO_0015903 GO:0015904 biolink:BiologicalProcess tetracycline transmembrane transport The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). go.json tetracyclin transport|tetracycline transport http://purl.obolibrary.org/obo/GO_0015904 GO:1902067 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902067 GO:0015905 biolink:BiologicalProcess bicyclomycin transmembrane transport The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. go.json bicyclomycin transport http://purl.obolibrary.org/obo/GO_0015905 GO:1902068 biolink:BiologicalProcess regulation of sphingolipid mediated signaling pathway Any process that modulates the frequency, rate or extent of sphingolipid signaling. go.json regulation of sphingolipid signaling pathway http://purl.obolibrary.org/obo/GO_1902068 GO:1902076 biolink:BiologicalProcess regulation of lateral motor column neuron migration Any process that modulates the frequency, rate or extent of lateral motor column neuron migration. go.json http://purl.obolibrary.org/obo/GO_1902076 GO:1902077 biolink:BiologicalProcess negative regulation of lateral motor column neuron migration Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration. go.json down regulation of lateral motor column neuron migration|down-regulation of lateral motor column neuron migration|downregulation of lateral motor column neuron migration|inhibition of lateral motor column neuron migration http://purl.obolibrary.org/obo/GO_1902077 GO:0015900 biolink:BiologicalProcess obsolete benomyl transport OBSOLETE. The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit. go.json True http://purl.obolibrary.org/obo/GO_0015900 GO:1902074 biolink:BiologicalProcess response to salt Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. go.json response to salinity http://purl.obolibrary.org/obo/GO_1902074 GO:0015901 biolink:BiologicalProcess cycloheximide transport The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. go.json http://purl.obolibrary.org/obo/GO_0015901 GO:1902075 biolink:BiologicalProcess cellular response to salt Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. go.json cellular response to salinity http://purl.obolibrary.org/obo/GO_1902075 GO:1902072 biolink:BiologicalProcess negative regulation of hypoxia-inducible factor-1alpha signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. go.json down regulation of HIF1alpha pathway|down regulation of hypoxia-inducible factor-1alpha signaling pathway|down regulation of hypoxia-inducible factor-1alpha signalling pathway|down-regulation of HIF1alpha pathway|down-regulation of hypoxia-inducible factor-1alpha signaling pathway|down-regulation of hypoxia-inducible factor-1alpha signalling pathway|downregulation of HIF1alpha pathway|downregulation of hypoxia-inducible factor-1alpha signaling pathway|downregulation of hypoxia-inducible factor-1alpha signalling pathway|inhibition of HIF1alpha pathway|inhibition of hypoxia-inducible factor-1alpha signaling pathway|inhibition of hypoxia-inducible factor-1alpha signalling pathway|negative regulation of HIF1alpha pathway|negative regulation of hypoxia-inducible factor-1alpha signalling pathway http://purl.obolibrary.org/obo/GO_1902072 GO:1902073 biolink:BiologicalProcess positive regulation of hypoxia-inducible factor-1alpha signaling pathway Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. go.json activation of HIF1alpha pathway|activation of hypoxia-inducible factor-1alpha signaling pathway|activation of hypoxia-inducible factor-1alpha signalling pathway|hypoxic stabilization of HIF1A|positive regulation of HIF1alpha pathway|positive regulation of hypoxia-inducible factor-1alpha signalling pathway|up regulation of HIF1alpha pathway|up regulation of hypoxia-inducible factor-1alpha signaling pathway|up regulation of hypoxia-inducible factor-1alpha signalling pathway|up-regulation of HIF1alpha pathway|up-regulation of hypoxia-inducible factor-1alpha signaling pathway|up-regulation of hypoxia-inducible factor-1alpha signalling pathway|upregulation of HIF1alpha pathway|upregulation of hypoxia-inducible factor-1alpha signaling pathway|upregulation of hypoxia-inducible factor-1alpha signalling pathway http://purl.obolibrary.org/obo/GO_1902073 GO:1902070 biolink:BiologicalProcess positive regulation of sphingolipid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of sphingolipid signaling. go.json activation of sphingolipid mediated signaling pathway|activation of sphingolipid signaling pathway|positive regulation of sphingolipid signaling pathway|up regulation of sphingolipid mediated signaling pathway|up regulation of sphingolipid signaling pathway|up-regulation of sphingolipid mediated signaling pathway|up-regulation of sphingolipid signaling pathway|upregulation of sphingolipid mediated signaling pathway|upregulation of sphingolipid signaling pathway http://purl.obolibrary.org/obo/GO_1902070 GO:1902071 biolink:BiologicalProcess regulation of hypoxia-inducible factor-1alpha signaling pathway Any process that modulates the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. go.json regulation of HIF1alpha pathway|regulation of hypoxia-inducible factor-1alpha signalling pathway http://purl.obolibrary.org/obo/GO_1902071 GO:1902078 biolink:BiologicalProcess positive regulation of lateral motor column neuron migration Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration. go.json activation of lateral motor column neuron migration|up regulation of lateral motor column neuron migration|up-regulation of lateral motor column neuron migration|upregulation of lateral motor column neuron migration http://purl.obolibrary.org/obo/GO_1902078 GO:1902079 biolink:BiologicalProcess D-valine catabolic process The chemical reactions and pathways resulting in the breakdown of D-valine. go.json D-valine breakdown|D-valine catabolism|D-valine degradation http://purl.obolibrary.org/obo/GO_1902079 GO:1902087 biolink:BiologicalProcess dimethylsulfoniopropionate catabolic process The chemical reactions and pathways resulting in the breakdown of S,S-dimethyl-beta-propiothetin. go.json S,S-dimethyl-beta-propiothetin breakdown|S,S-dimethyl-beta-propiothetin catabolic process|S,S-dimethyl-beta-propiothetin catabolism|S,S-dimethyl-beta-propiothetin degradation http://purl.obolibrary.org/obo/GO_1902087 GO:1902088 biolink:BiologicalProcess plant-type cell wall loosening involved in abscission Any plant-type cell wall loosening that is involved in abscission. go.json cellulose and pectin-containing cell wall loosening involved in abscission http://purl.obolibrary.org/obo/GO_1902088 GO:1902085 biolink:BiologicalProcess fumagillin catabolic process The chemical reactions and pathways resulting in the breakdown of fumagillin. go.json fumagillin breakdown|fumagillin catabolism|fumagillin degradation http://purl.obolibrary.org/obo/GO_1902085 GO:1902086 biolink:BiologicalProcess fumagillin biosynthetic process The chemical reactions and pathways resulting in the formation of fumagillin. go.json fumagillin anabolism|fumagillin biosynthesis|fumagillin formation|fumagillin synthesis http://purl.obolibrary.org/obo/GO_1902086 GO:1902083 biolink:BiologicalProcess negative regulation of peptidyl-cysteine S-nitrosylation Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation. go.json down regulation of S-nitrosylation|down regulation of peptidyl-cysteine S-nitrosylation|down regulation of protein S-nitrosylation|down-regulation of S-nitrosylation|down-regulation of peptidyl-cysteine S-nitrosylation|down-regulation of protein S-nitrosylation|downregulation of S-nitrosylation|downregulation of peptidyl-cysteine S-nitrosylation|downregulation of protein S-nitrosylation|inhibition of S-nitrosylation|inhibition of peptidyl-cysteine S-nitrosylation|inhibition of protein S-nitrosylation|negative regulation of S-nitrosylation|negative regulation of protein S-nitrosylation http://purl.obolibrary.org/obo/GO_1902083 GO:1902084 biolink:BiologicalProcess fumagillin metabolic process The chemical reactions and pathways involving fumagillin. go.json fumagillin metabolism http://purl.obolibrary.org/obo/GO_1902084 GO:1902081 biolink:BiologicalProcess negative regulation of calcium ion import into sarcoplasmic reticulum Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. go.json down regulation of calcium ion import into sarcoplasmic reticulum|down-regulation of calcium ion import into sarcoplasmic reticulum|downregulation of calcium ion import into sarcoplasmic reticulum|inhibition of calcium ion import into sarcoplasmic reticulum http://purl.obolibrary.org/obo/GO_1902081 GO:1902082 biolink:BiologicalProcess positive regulation of calcium ion import into sarcoplasmic reticulum Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. go.json activation of calcium ion import into sarcoplasmic reticulum|up regulation of calcium ion import into sarcoplasmic reticulum|up-regulation of calcium ion import into sarcoplasmic reticulum|upregulation of calcium ion import into sarcoplasmic reticulum http://purl.obolibrary.org/obo/GO_1902082 GO:1902080 biolink:BiologicalProcess regulation of calcium ion import into sarcoplasmic reticulum Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_1902080 GO:1902089 biolink:BiologicalProcess cell wall polysaccharide catabolic process involved in lateral root development Any cell wall polysaccharide catabolic process that is involved in lateral root development. go.json cell wall polysaccharide breakdown involved in lateral root development http://purl.obolibrary.org/obo/GO_1902089 GO:1902098 biolink:MolecularActivity calcitriol binding Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3. go.json 1,25-dihydroxycholecalciferol binding|1,25-dihydroxyvitamin D3 binding|1alpha,25(OH)2 vitamin D3 binding|1alpha,25(OH)2D3 binding|1alpha,25-dihydroxycholecalciferol binding|1alpha,25-dihydroxyvitamin D3 binding|hormonally active vitamin D3 binding http://purl.obolibrary.org/obo/GO_1902098 GO:1902099 biolink:BiologicalProcess regulation of metaphase/anaphase transition of cell cycle Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle. go.json http://purl.obolibrary.org/obo/GO_1902099 GO:1902096 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902096 GO:1902097 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium. go.json activation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|activation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|positive regulation of global transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity|positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacteria|positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacterium|positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacteria|positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacterium|positive regulation of transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity|positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacteria|positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacterium|positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacteria|positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacterium|positive regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|stimulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|stimulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|up regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|up regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|up-regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|up-regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|upregulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium|upregulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity|upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria|upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium|upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria|upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium True http://purl.obolibrary.org/obo/GO_1902097 GO:1902094 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902094 GO:1902095 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902095 GO:1902092 biolink:BiologicalProcess positive regulation of fumagillin biosynthetic process Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process. go.json activation of fumagillin anabolism|activation of fumagillin biosynthesis|activation of fumagillin biosynthetic process|activation of fumagillin formation|activation of fumagillin synthesis|positive regulation of fumagillin anabolism|positive regulation of fumagillin biosynthesis|positive regulation of fumagillin formation|positive regulation of fumagillin synthesis|up regulation of fumagillin anabolism|up regulation of fumagillin biosynthesis|up regulation of fumagillin biosynthetic process|up regulation of fumagillin formation|up regulation of fumagillin synthesis|up-regulation of fumagillin anabolism|up-regulation of fumagillin biosynthesis|up-regulation of fumagillin biosynthetic process|up-regulation of fumagillin formation|up-regulation of fumagillin synthesis|upregulation of fumagillin anabolism|upregulation of fumagillin biosynthesis|upregulation of fumagillin biosynthetic process|upregulation of fumagillin formation|upregulation of fumagillin synthesis http://purl.obolibrary.org/obo/GO_1902092 GO:1902093 biolink:BiologicalProcess positive regulation of flagellated sperm motility Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. go.json activation of sperm motility|activation of sperm movement|positive regulation of sperm motility|positive regulation of sperm movement|up regulation of sperm motility|up regulation of sperm movement|up-regulation of sperm motility|up-regulation of sperm movement|upregulation of sperm motility|upregulation of sperm movement http://purl.obolibrary.org/obo/GO_1902093 GO:1902090 biolink:BiologicalProcess regulation of fumagillin biosynthetic process Any process that modulates the frequency, rate or extent of fumagillin biosynthetic process. go.json regulation of fumagillin anabolism|regulation of fumagillin biosynthesis|regulation of fumagillin formation|regulation of fumagillin synthesis http://purl.obolibrary.org/obo/GO_1902090 GO:1902091 biolink:BiologicalProcess negative regulation of fumagillin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process. go.json down regulation of fumagillin anabolism|down regulation of fumagillin biosynthesis|down regulation of fumagillin biosynthetic process|down regulation of fumagillin formation|down regulation of fumagillin synthesis|down-regulation of fumagillin anabolism|down-regulation of fumagillin biosynthesis|down-regulation of fumagillin biosynthetic process|down-regulation of fumagillin formation|down-regulation of fumagillin synthesis|downregulation of fumagillin anabolism|downregulation of fumagillin biosynthesis|downregulation of fumagillin biosynthetic process|downregulation of fumagillin formation|downregulation of fumagillin synthesis|inhibition of fumagillin anabolism|inhibition of fumagillin biosynthesis|inhibition of fumagillin biosynthetic process|inhibition of fumagillin formation|inhibition of fumagillin synthesis|negative regulation of fumagillin anabolism|negative regulation of fumagillin biosynthesis|negative regulation of fumagillin formation|negative regulation of fumagillin synthesis http://purl.obolibrary.org/obo/GO_1902091 GO:0015898 biolink:BiologicalProcess obsolete amiloride transport OBSOLETE. The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. go.json True http://purl.obolibrary.org/obo/GO_0015898 GO:0015899 biolink:BiologicalProcess aminotriazole transport The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity. go.json http://purl.obolibrary.org/obo/GO_0015899 GO:0015894 biolink:BiologicalProcess obsolete acriflavine transport OBSOLETE. The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. go.json acriflavin transport True http://purl.obolibrary.org/obo/GO_0015894 GO:0015895 biolink:BiologicalProcess alkane transport The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds. go.json http://purl.obolibrary.org/obo/GO_0015895 GO:0015896 biolink:BiologicalProcess obsolete nalidixic acid transport OBSOLETE. The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. go.json True http://purl.obolibrary.org/obo/GO_0015896 GO:0015897 biolink:BiologicalProcess organomercurial transport The process in which an organomercurial compound is transported across a membrane. Organomercurial substances are any organic compound containing a mercury atom. go.json http://purl.obolibrary.org/obo/GO_0015897 GO:0015890 biolink:BiologicalProcess nicotinamide mononucleotide transport The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP. go.json nicotinamide ribonucleotide transport http://purl.obolibrary.org/obo/GO_0015890 GO:0015891 biolink:BiologicalProcess siderophore transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json iron-siderochrome transport|iron-siderophore transport|siderochrome transport|siderophore-iron transport http://purl.obolibrary.org/obo/GO_0015891 goslim_pir GO:0015892 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015892 GO:0015893 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015893 GO:0050202 biolink:MolecularActivity octopamine dehydratase activity Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4. EC:4.2.1.87|KEGG_REACTION:R03358|MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN|RHEA:18173 go.json octopamine hydro-lyase (deaminating)|octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]|octopamine hydrolyase activity http://purl.obolibrary.org/obo/GO_0050202 GO:0050203 biolink:MolecularActivity oxalate-CoA ligase activity Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA. EC:6.2.1.8|KEGG_REACTION:R01558|MetaCyc:OXALATE--COA-LIGASE-RXN|RHEA:18293 go.json oxalate:CoA ligase (AMP-forming)|oxalyl coenzyme A synthetase activity|oxalyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0050203 GO:0050200 biolink:MolecularActivity plasmalogen synthase activity Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine. EC:2.3.1.25|MetaCyc:PLASMALOGEN-SYNTHASE-RXN go.json 1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity|O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity|acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity|lysoplasmenylcholine acyltransferase activity http://purl.obolibrary.org/obo/GO_0050200 GO:0050201 biolink:MolecularActivity fucokinase activity Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+. EC:2.7.1.52|KEGG_REACTION:R03161|MetaCyc:FUCOKINASE-RXN|RHEA:13241|Reactome:R-HSA-6787540 go.json ATP:6-deoxy-L-galactose 1-phosphotransferase activity|ATP:beta-L-fucose 1-phosphotransferase activity|L-fucokinase activity|L-fucose kinase activity|fucokinase (phosphorylating) activity|fucose kinase activity http://purl.obolibrary.org/obo/GO_0050201 GO:0050206 biolink:MolecularActivity oximinotransferase activity Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate. EC:2.6.3.1|KEGG_REACTION:R03796|MetaCyc:OXIMINOTRANSFERASE-RXN|RHEA:11624 go.json oximase activity|oximinotransaminase activity|pyruvate-acetone oximinotransferase activity|transoximase activity|transoximinase activity http://purl.obolibrary.org/obo/GO_0050206 GO:0050207 biolink:MolecularActivity plasmanylethanolamine desaturase activity Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O. EC:1.14.19.77|MetaCyc:RXN-17732|RHEA:22956 go.json 2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase activity|alkylacylglycero-phosphorylethanolamine dehydrogenase activity|alkylacylglycerophosphoethanolamine desaturase activity|plasmenylethanolamine desaturase activity http://purl.obolibrary.org/obo/GO_0050207 GO:0050204 biolink:MolecularActivity oxalomalate lyase activity Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate. EC:4.1.3.13|KEGG_REACTION:R00477|MetaCyc:OXALOMALATE-LYASE-RXN|RHEA:22032 go.json 3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)|3-oxalomalate glyoxylate-lyase activity http://purl.obolibrary.org/obo/GO_0050204 GO:0050205 biolink:MolecularActivity oxamate carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate. EC:2.1.3.5|KEGG_REACTION:R02937|MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN|RHEA:22984 go.json carbamoyl-phosphate:oxamate carbamoyltransferase activity|oxamic transcarbamylase activity http://purl.obolibrary.org/obo/GO_0050205 GO:0050208 biolink:MolecularActivity polysialic-acid O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9. EC:2.3.1.136|MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN|RHEA:11604 go.json acetyl-CoA:polysialic-acid O-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0050208 GO:0050209 biolink:MolecularActivity polyvinyl-alcohol oxidase activity Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2. EC:1.1.3.30|MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN|RHEA:21688 go.json PVA oxidase activity|dehydrogenase, polyvinyl alcohol|polyvinyl-alcohol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050209 GO:0015876 biolink:BiologicalProcess acetyl-CoA transport The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0015876 GO:0015877 biolink:BiologicalProcess biopterin transport The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. go.json http://purl.obolibrary.org/obo/GO_0015877 GO:0015878 biolink:BiologicalProcess biotin transport The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. go.json vitamin B7 transport|vitamin H transport http://purl.obolibrary.org/obo/GO_0015878 GO:0015879 biolink:BiologicalProcess carnitine transport The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. go.json vitamin Bt transport http://purl.obolibrary.org/obo/GO_0015879 GO:0015872 biolink:BiologicalProcess dopamine transport The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. go.json http://purl.obolibrary.org/obo/GO_0015872 GO:0015873 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015873 GO:0015874 biolink:BiologicalProcess norepinephrine transport The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. go.json levarterenol transport|noradrenaline transport http://purl.obolibrary.org/obo/GO_0015874 GO:0015875 biolink:BiologicalProcess obsolete vitamin or cofactor transport OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells. go.json vitamin or cofactor transport True http://purl.obolibrary.org/obo/GO_0015875 GO:0015870 biolink:BiologicalProcess acetylcholine transport The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. go.json http://purl.obolibrary.org/obo/GO_0015870 GO:0015871 biolink:BiologicalProcess choline transport The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. go.json http://purl.obolibrary.org/obo/GO_0015871 GO:0050213 biolink:MolecularActivity obsolete progesterone 5-alpha-reductase activity OBSOLETE. Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. go.json 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity|delta4-steroid 5alpha-reductase (progesterone)|progesterone 5a-reductase activity|progesterone 5alpha-reductase activity|steroid 5-alpha-reductase activity True http://purl.obolibrary.org/obo/GO_0050213 GO:0050214 biolink:MolecularActivity progesterone monooxygenase activity Catalysis of the reaction: AH(2) + O2 + progesterone = A + H2O + testosterone acetate. EC:1.14.99.4|KEGG_REACTION:R02212|MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN|RHEA:11984 go.json progesterone hydroxylase activity|progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0050214 GO:0050211 biolink:MolecularActivity procollagen galactosyltransferase activity Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. EC:2.4.1.50|MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN|RHEA:12637|Reactome:R-HSA-1981120|Reactome:R-HSA-1981128 go.json UDP galactose-collagen galactosyltransferase activity|UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity|UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity|UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity|collagen galactosyltransferase activity|collagen hydroxylysyl galactosyltransferase activity|hydroxylysine galactosyltransferase activity|uridine diphosphogalactose-collagen galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0050211 GO:0050212 biolink:MolecularActivity progesterone 11-alpha-monooxygenase activity Catalysis of the reaction: AH(2) + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O. EC:1.14.99.14|KEGG_REACTION:R02214|MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN|RHEA:18205 go.json progesterone 11-alpha-hydroxylase activity|progesterone 11a-monooxygenase activity|progesterone 11alpha-hydroxylase activity|progesterone 11alpha-monooxygenase activity|progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating) http://purl.obolibrary.org/obo/GO_0050212 GO:0050217 biolink:MolecularActivity propioin synthase activity Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal. EC:4.1.2.35|KEGG_REACTION:R00038|MetaCyc:PROPIOIN-SYNTHASE-RXN|RHEA:11100 go.json 4-hydroxy-3-hexanone aldolase activity|4-hydroxy-3-hexanone propanal-lyase (propanal-forming)|4-hydroxy-3-hexanone propanal-lyase activity http://purl.obolibrary.org/obo/GO_0050217 GO:0050218 biolink:MolecularActivity propionate-CoA ligase activity Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. EC:6.2.1.17|MetaCyc:PROPIONATE--COA-LIGASE-RXN|RHEA:20373 go.json propanoate:CoA ligase (AMP-forming)|propionyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0050218 GO:0050215 biolink:MolecularActivity propanediol dehydratase activity Catalysis of the reaction: propane-1,2-diol = H2O + propanal. EC:4.2.1.28|KEGG_REACTION:R02376|MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN|RHEA:14569 go.json 1,2-propanediol dehydratase activity|DL-1,2-propanediol hydro-lyase activity|adenosylcobalamin-dependent diol dehydratase activity|coenzyme B12-dependent diol dehydrase activity|diol dehydrase activity|diol dehydratase activity|dioldehydratase activity|meso-2,3-butanediol dehydrase activity|propane-1,2-diol hydro-lyase (propanal-forming)|propane-1,2-diol hydro-lyase activity|propanediol dehydrase activity http://purl.obolibrary.org/obo/GO_0050215 GO:0050216 biolink:MolecularActivity propanediol-phosphate dehydrogenase activity Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH. EC:1.1.1.7|KEGG_REACTION:R04236|MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN|RHEA:21584 go.json http://purl.obolibrary.org/obo/GO_0050216 GO:0050219 biolink:MolecularActivity prostaglandin-A1 delta-isomerase activity Catalysis of the reaction: prostaglandin A1 = prostaglandin C1. EC:5.3.3.9|KEGG_REACTION:R04565|MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN|RHEA:10460 go.json (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity|prostaglandin A isomerase activity|prostaglandin-A1 D-isomerase activity http://purl.obolibrary.org/obo/GO_0050219 GO:0015887 biolink:BiologicalProcess pantothenate transmembrane transport The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. go.json pantothenate membrane transport|pantothenate transport|vitamin B5 transport http://purl.obolibrary.org/obo/GO_0015887 GO:0015888 biolink:BiologicalProcess thiamine transport The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. go.json thiamin transport|vitamin B1 transport http://purl.obolibrary.org/obo/GO_0015888 GO:0015889 biolink:BiologicalProcess cobalamin transport The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json vitamin B12 transport http://purl.obolibrary.org/obo/GO_0015889 GO:0015883 biolink:BiologicalProcess FAD transport The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. go.json flavin adenine dinucleotide transport|flavin-adenine dinucleotide transport http://purl.obolibrary.org/obo/GO_0015883 GO:0015884 biolink:BiologicalProcess folic acid transport The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. go.json folate transport|vitamin B9 transport|vitamin M transport http://purl.obolibrary.org/obo/GO_0015884 GO:0015885 biolink:BiologicalProcess 5-formyltetrahydrofolate transport The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015885 GO:0015886 biolink:BiologicalProcess heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json haem transport http://purl.obolibrary.org/obo/GO_0015886 GO:0015880 biolink:BiologicalProcess coenzyme A transport The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. go.json http://purl.obolibrary.org/obo/GO_0015880 GO:0015881 biolink:BiologicalProcess creatine transmembrane transport The directed movement of creatine across a membrane. go.json creatine transport http://purl.obolibrary.org/obo/GO_0015881 GO:0015882 biolink:BiologicalProcess L-ascorbic acid transmembrane transport The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. go.json L-ascorbate transport|L-ascorbic acid transport|vitamin C transport http://purl.obolibrary.org/obo/GO_0015882 GO:0050210 biolink:MolecularActivity prenyl-diphosphatase activity Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. EC:3.1.7.1|MetaCyc:PRENYL-PYROPHOSPHATASE-RXN|RHEA:21496 go.json prenol pyrophosphatase activity|prenyl-diphosphate diphosphohydrolase activity|prenyl-pyrophosphatase activity|prenylphosphatase activity http://purl.obolibrary.org/obo/GO_0050210 GO:0001213 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001213 GO:0050224 biolink:MolecularActivity prunasin beta-glucosidase activity Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile. EC:3.2.1.118|KEGG_REACTION:R02558|MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN|RHEA:16489 go.json prunasin b-glucosidase activity|prunasin beta-D-glucohydrolase activity|prunasin hydrolase activity http://purl.obolibrary.org/obo/GO_0050224 GO:0050225 biolink:MolecularActivity pseudouridine kinase activity Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H+ + pseudouridine 5'-phosphate. EC:2.7.1.83|KEGG_REACTION:R03315|MetaCyc:PSEUDOURIDINE-KINASE-RXN|RHEA:22448 go.json ATP:pseudouridine 5'-phosphotransferase activity|pseudouridine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050225 GO:0001214 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001214 GO:0001215 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001215 GO:0050222 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050222 GO:0050223 biolink:MolecularActivity protocatechuate decarboxylase activity Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2. EC:4.1.1.63|KEGG_REACTION:R00822|MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN|RHEA:22416 go.json 3,4-dihydrobenzoate decarboxylase activity|3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)|3,4-dihydroxybenzoate decarboxylase activity|protocatechuate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0050223 GO:0001216 biolink:MolecularActivity DNA-binding transcription activator activity A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. go.json bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding|metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription|transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding|transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001216 GO:0050228 biolink:MolecularActivity pterin deaminase activity Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3. EC:3.5.4.11|MetaCyc:PTERIN-DEAMINASE-RXN|RHEA:11904 go.json 2-amino-4-hydroxypteridine aminohydrolase activity|acrasinase activity http://purl.obolibrary.org/obo/GO_0050228 GO:0050229 biolink:MolecularActivity obsolete pterocarpin synthase activity OBSOLETE. Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH. EC:1.1.1.246|MetaCyc:PTEROCARPIN-SYNTHASE-RXN go.json medicarpin:NADP+ 2'-oxidoreductase activity|pterocarpan synthase activity True http://purl.obolibrary.org/obo/GO_0050229 GO:0001210 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001210 GO:0050226 biolink:MolecularActivity psychosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate. EC:2.8.2.13|MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN|RHEA:14137 go.json 3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity|3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity|PAPS:psychosine sulphotransferase activity|psychosine sulphotransferase activity http://purl.obolibrary.org/obo/GO_0050226 GO:0001211 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001211 GO:0001212 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001212 GO:0050227 biolink:MolecularActivity pteridine oxidase activity Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown. EC:1.17.3.1|MetaCyc:PTERIDINE-OXIDASE-RXN|RHEA:12777 go.json 2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating) http://purl.obolibrary.org/obo/GO_0050227 GO:0015858 biolink:BiologicalProcess nucleoside transport The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015858 GO:0015859 biolink:BiologicalProcess intracellular nucleoside transport The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell. go.json http://purl.obolibrary.org/obo/GO_0015859 GO:0015854 biolink:BiologicalProcess guanine transport The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015854 GO:0015855 biolink:BiologicalProcess pyrimidine nucleobase transport The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json pyrimidine base transmembrane transport|pyrimidine base transport|pyrimidine transmembrane transport|pyrimidine transport http://purl.obolibrary.org/obo/GO_0015855 GO:0015856 biolink:BiologicalProcess cytosine transport The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json cytosine transmembrane transport http://purl.obolibrary.org/obo/GO_0015856 GO:0015857 biolink:BiologicalProcess uracil transport The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015857 GO:0015850 biolink:BiologicalProcess organic hydroxy compound transport The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. go.json organic alcohol transport http://purl.obolibrary.org/obo/GO_0015850 GO:0015851 biolink:BiologicalProcess nucleobase transport The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json nucleobase transmembrane transport http://purl.obolibrary.org/obo/GO_0015851 GO:0015852 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015852 GO:0015853 biolink:BiologicalProcess adenine transport The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json adenine transmembrane transport http://purl.obolibrary.org/obo/GO_0015853 GO:0050220 biolink:MolecularActivity prostaglandin-E synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). EC:5.3.99.3|KEGG_REACTION:R02265|MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN|RHEA:12893|Reactome:R-HSA-2161660|Reactome:R-HSA-265295 go.json (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity|PGE isomerase activity|PGE2 isomerase activity|PGH-PGE isomerase activity|Prostaglandin-H(2) E-isomerase activity|endoperoxide isomerase activity|prostaglandin H-E isomerase activity|prostaglandin R-prostaglandin E isomerase activity|prostaglandin endoperoxide E isomerase activity|prostaglandin endoperoxide E2 isomerase activity|prostaglandin-H2 E-isomerase activity http://purl.obolibrary.org/obo/GO_0050220 GO:0001217 biolink:MolecularActivity DNA-binding transcription repressor activity A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. go.json bacterial-type DNA binding transcription repressor activity|bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding|cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding|transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001217 GO:0050221 biolink:MolecularActivity prostaglandin-E2 9-reductase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. EC:1.1.1.189|MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN|RHEA:24508|Reactome:R-HSA-2161651 go.json (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity|9-keto-prostaglandin E(2) reductase activity|9-keto-prostaglandin E2 reductase activity|9-ketoprostaglandin reductase activity|PGE(2) 9-ketoreductase activity|PGE(2) 9-oxoreductase activity|PGE-9-ketoreductase activity|PGE2 9-ketoreductase activity|PGE2 9-oxoreductase activity|PGE2-9-OR|PGE2-9-ketoreductase activity|prostaglandin E 9-ketoreductase activity|prostaglandin E2-9-oxoreductase activity|prostaglandin-E(2) 9-oxoreductase activity|prostaglandin-E2 9-oxoreductase activity|reductase, 15-hydroxy-9-oxoprostaglandin http://purl.obolibrary.org/obo/GO_0050221 GO:0001218 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001218 GO:0001219 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001219 GO:0050235 biolink:MolecularActivity pyridoxal 4-dehydrogenase activity Catalysis of the reaction: NAD+ + pyridoxal = 4-pyridoxolactone + H+ + NADH. EC:1.1.1.107|KEGG_REACTION:R01707|MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN|RHEA:21336 go.json pyridoxal dehydrogenase activity|pyridoxal:NAD+ 4-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050235 GO:0001224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001224 GO:0050236 biolink:MolecularActivity pyridoxine:NADP 4-dehydrogenase activity Catalysis of the reaction: NADP+ + pyridoxine = H+ + NADPH + pyridoxal. EC:1.1.1.65|KEGG_REACTION:R01708|MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN|RHEA:16129 go.json PL reductase activity|pyridoxal reductase activity|pyridoxin dehydrogenase activity|pyridoxine dehydrogenase activity|pyridoxine:NADP 4-oxidoreductase activity|pyridoxol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050236 GO:0001225 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001225 GO:0001226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001226 GO:0050233 biolink:MolecularActivity pyranose oxidase activity Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2. EC:1.1.3.10|KEGG_REACTION:R00302|MetaCyc:PYRANOSE-OXIDASE-RXN|RHEA:10552 go.json glucose 2-oxidase activity|pyranose-2-oxidase activity|pyranose:oxygen 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050233 GO:0001227 biolink:MolecularActivity DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. go.json RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding|RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding|distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription|metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcriptional repressor activity, metal ion regulated sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001227 GO:0050234 biolink:MolecularActivity pyrazolylalanine synthase activity Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O. EC:4.2.1.50|KEGG_REACTION:R02378|MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN|RHEA:24512 go.json L-serine hydro-lyase (adding pyrazole)|L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]|beta-pyrazolylalaninase activity http://purl.obolibrary.org/obo/GO_0050234 GO:0001220 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001220 GO:0050239 biolink:MolecularActivity pyrithiamine deaminase activity Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3. EC:3.5.4.20|MetaCyc:PYRITHIAMIN-DEAMINASE-RXN|RHEA:14537 go.json 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity http://purl.obolibrary.org/obo/GO_0050239 GO:0001221 biolink:MolecularActivity transcription coregulator binding Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. go.json RNA polymerase II transcription cofactor binding|RNA polymerase II transcription coregulator binding|transcription cofactor binding http://purl.obolibrary.org/obo/GO_0001221 GO:0050237 biolink:MolecularActivity pyridoxine 4-oxidase activity Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2. EC:1.1.3.12|MetaCyc:PYRIDOXINE-4-OXIDASE-RXN|RHEA:15033 go.json pyridoxin 4-oxidase activity|pyridoxine:oxygen 4-oxidoreductase activity|pyridoxol 4-oxidase activity http://purl.obolibrary.org/obo/GO_0050237 GO:0001222 biolink:MolecularActivity transcription corepressor binding Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. go.json RNA polymerase II transcription corepressor binding http://purl.obolibrary.org/obo/GO_0001222 GO:0050238 biolink:MolecularActivity pyridoxine 5-dehydrogenase activity Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor. EC:1.1.99.9|MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN|RHEA:14497 go.json pyridoxal-5-dehydrogenase activity|pyridoxin 5-dehydrogenase activity|pyridoxine 5'-dehydrogenase activity|pyridoxine:(acceptor) 5-oxidoreductase activity|pyridoxine:acceptor 5-oxidoreductase activity|pyridoxol 5-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050238 GO:0001223 biolink:MolecularActivity transcription coactivator binding Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. go.json RNA polymerase II transcription coactivator binding http://purl.obolibrary.org/obo/GO_0001223 GO:0015869 biolink:BiologicalProcess protein-DNA complex transport The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json DNA-protein complex transport http://purl.obolibrary.org/obo/GO_0015869 GO:0015865 biolink:BiologicalProcess purine nucleotide transport The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0015865 GO:0015866 biolink:BiologicalProcess ADP transport The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015866 GO:0015867 biolink:BiologicalProcess ATP transport The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015867 GO:0015868 biolink:BiologicalProcess purine ribonucleotide transport The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0015868 GO:0015861 biolink:BiologicalProcess cytidine transport The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015861 GO:0015862 biolink:BiologicalProcess uridine transport The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015862 GO:0015863 biolink:BiologicalProcess xanthosine transport The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015863 GO:0015864 biolink:BiologicalProcess pyrimidine nucleoside transport The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015864 GO:0015860 biolink:BiologicalProcess purine nucleoside transmembrane transport The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. go.json purine nucleoside membrane transport|purine nucleoside transport http://purl.obolibrary.org/obo/GO_0015860 GO:0001228 biolink:MolecularActivity DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. go.json RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding|RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding|RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcriptional activator activity, metal ion regulated sequence-specific DNA binding|zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription http://purl.obolibrary.org/obo/GO_0001228 GO:0050231 biolink:MolecularActivity putrescine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H+ + phosphate. EC:2.1.3.6|KEGG_REACTION:R01399|MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN|RHEA:21936 go.json PTCase activity|carbamoyl-phosphate:putrescine carbamoyltransferase activity|putrescine synthase activity|putrescine transcarbamylase activity http://purl.obolibrary.org/obo/GO_0050231 GO:0050232 biolink:MolecularActivity putrescine oxidase activity Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2. EC:1.4.3.10|MetaCyc:PUTRESCINE-OXIDASE-RXN|RHEA:18273 go.json putrescine:oxygen oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0050232 GO:0050230 biolink:MolecularActivity purine imidazole-ring cyclase activity Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O. EC:4.3.2.4|MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN go.json DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)|DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)|DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming) http://purl.obolibrary.org/obo/GO_0050230 GO:0050246 biolink:MolecularActivity questin monooxygenase activity Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+. EC:1.14.13.43|KEGG_REACTION:R02417|MetaCyc:QUESTIN-MONOOXYGENASE-RXN|RHEA:10836 go.json questin oxygenase activity|questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening) http://purl.obolibrary.org/obo/GO_0050246 GO:0050247 biolink:MolecularActivity raucaffricine beta-glucosidase activity Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine. EC:3.2.1.125|KEGG_REACTION:R03703|MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN|RHEA:14557 go.json raucaffricine b-glucosidase activity|raucaffricine beta-D-glucohydrolase activity|raucaffricine beta-D-glucosidase activity|raucaffricine glucosidase activity http://purl.obolibrary.org/obo/GO_0050247 GO:0050244 biolink:MolecularActivity pyruvate oxidase (CoA-acetylating) activity Catalysis of the reaction: CoA + H+ + O2 + pyruvate = acetyl-CoA + CO2 + H2O2. EC:1.2.3.6|KEGG_REACTION:R00211|MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN|RHEA:21912 go.json pyruvate:oxygen 2-oxidoreductase (CoA-acetylating) http://purl.obolibrary.org/obo/GO_0050244 GO:0050245 biolink:MolecularActivity quercitrinase activity Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin. EC:3.2.1.66|KEGG_REACTION:R02436|MetaCyc:QUERCITRINASE-RXN|RHEA:17465 go.json quercitrin 3-L-rhamnohydrolase activity http://purl.obolibrary.org/obo/GO_0050245 GO:0050248 biolink:MolecularActivity Renilla-luciferin 2-monooxygenase activity Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light. EC:1.13.12.5|MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN|RHEA:14765 go.json Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)|Renilla-type luciferase activity|aequorin activity|luciferase (Renilla luciferin)|luciferase activity http://purl.obolibrary.org/obo/GO_0050248 GO:0050249 biolink:MolecularActivity Renilla-luciferin sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate. EC:2.8.2.10|KEGG_REACTION:R03138|MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN|RHEA:20481 go.json 3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity|Renilla-luciferin sulphotransferase activity|luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)|luciferin sulfokinase activity|luciferin sulfotransferase activity http://purl.obolibrary.org/obo/GO_0050249 GO:0015836 biolink:BiologicalProcess lipid-linked peptidoglycan transport The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json lipid-linked murein transport http://purl.obolibrary.org/obo/GO_0015836 GO:0015837 biolink:BiologicalProcess amine transport The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json amine/polyamine transport http://purl.obolibrary.org/obo/GO_0015837 goslim_pir GO:0015838 biolink:BiologicalProcess amino-acid betaine transport The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json betaine transport http://purl.obolibrary.org/obo/GO_0015838 GO:0015839 biolink:BiologicalProcess cadaverine transport The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015839 GO:0015832 biolink:BiologicalProcess obsolete holin OBSOLETE. (Was not defined before being made obsolete). go.json holin True http://purl.obolibrary.org/obo/GO_0015832 GO:1902000 biolink:BiologicalProcess homogentisate catabolic process The chemical reactions and pathways resulting in the breakdown of homogentisate. go.json homogentisate breakdown|homogentisate catabolism|homogentisate degradation http://purl.obolibrary.org/obo/GO_1902000 GO:0015833 biolink:BiologicalProcess peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015833 goslim_pir GO:0015834 biolink:BiologicalProcess peptidoglycan-associated peptide transport The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. go.json murein peptide transport|muropeptide transport|peptidoglycan peptide transport http://purl.obolibrary.org/obo/GO_0015834 GO:0015835 biolink:BiologicalProcess peptidoglycan transport The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json murein transport http://purl.obolibrary.org/obo/GO_0015835 goslim_pir GO:0015830 biolink:BiologicalProcess diaminopimelate transport The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015830 GO:0015831 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015831 GO:0050242 biolink:MolecularActivity pyruvate, phosphate dikinase activity Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate. EC:2.7.9.1|KEGG_REACTION:R00206|MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN|RHEA:10756 go.json ATP:pyruvate, phosphate phosphotransferase activity|PPDK|orthophosphate dikinase pyruvate|pyruvate, Pi dikinase activity|pyruvate,orthophosphate dikinase activity|pyruvate,phosphate dikinase activity|pyruvate-inorganic phosphate dikinase activity|pyruvate-phosphate dikinase (phosphorylating)|pyruvate-phosphate dikinase activity|pyruvate-phosphate ligase activity|pyruvic-phosphate dikinase activity|pyruvic-phosphate ligase activity http://purl.obolibrary.org/obo/GO_0050242 GO:0050243 biolink:MolecularActivity pyruvate dehydrogenase (NADP+) activity Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH. EC:1.2.1.51|KEGG_REACTION:R00210|MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN|RHEA:17425 go.json pyruvate:NADP(+) oxidoreductase activity|pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)|pyruvate:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050243 GO:0050240 biolink:MolecularActivity pyrogallol 1,2-oxygenase activity Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+. EC:1.13.11.35|KEGG_REACTION:R03246|MetaCyc:PYROGALLOL-12-OXYGENASE-RXN|RHEA:19673 go.json 1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)|pyrogallol 1,2-dioxygenase activity http://purl.obolibrary.org/obo/GO_0050240 GO:0050241 biolink:MolecularActivity pyrroline-2-carboxylate reductase activity Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+. EC:1.5.1.1|MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN go.json L-proline:NAD(P)+ 2-oxidoreductase activity|delta1-pyrroline-2-carboxylate reductase activity http://purl.obolibrary.org/obo/GO_0050241 GO:0001202 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001202 GO:0050257 biolink:MolecularActivity riboflavin phosphotransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN. EC:2.7.1.42|KEGG_REACTION:R00550|MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN|RHEA:20409 go.json D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity|G-1-P phosphotransferase activity|alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity|riboflavine phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050257 GO:0050258 biolink:MolecularActivity riboflavinase activity Catalysis of the reaction: H2O + H+ + riboflavin = D-ribitol + lumichrome. EC:3.5.99.1|KEGG_REACTION:R01732|MetaCyc:RIBOFLAVINASE-RXN|RHEA:11408 go.json riboflavin hydrolase activity http://purl.obolibrary.org/obo/GO_0050258 GO:0001203 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001203 GO:0050255 biolink:MolecularActivity ribitol 2-dehydrogenase activity Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH. EC:1.1.1.56|KEGG_REACTION:R01895|MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN|RHEA:20053 go.json adonitol dehydrogenase activity|ribitol dehydrogenase A (wild type)|ribitol dehydrogenase B (mutant enzyme with different properties)|ribitol dehydrogenase D (mutant enzyme with different properties)|ribitol:NAD+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050255 GO:0001204 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001204 GO:0050256 biolink:MolecularActivity ribitol-5-phosphate 2-dehydrogenase activity Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+. EC:1.1.1.137|MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN go.json D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity|dehydrogenase, ribitol 5-phosphate http://purl.obolibrary.org/obo/GO_0050256 GO:0001205 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001205 GO:1902009 biolink:BiologicalProcess positive regulation of toxin transport Any process that activates or increases the frequency, rate or extent of toxin transport. go.json activation of toxin transport|up regulation of toxin transport|up-regulation of toxin transport|upregulation of toxin transport http://purl.obolibrary.org/obo/GO_1902009 GO:0001200 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001200 GO:0050259 biolink:MolecularActivity ribose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: H2O + NADP+ + ribofuranose = D-ribonate + 2 H+ + NADPH. EC:1.1.1.115|KEGG_REACTION:R01079|MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:11676 go.json D-ribose dehydrogenase (NADP+)|D-ribose:NADP+ 1-oxidoreductase activity|NADP-pentose-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050259 GO:0001201 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001201 GO:1902007 biolink:BiologicalProcess regulation of toxin transport Any process that modulates the frequency, rate or extent of toxin transport. go.json http://purl.obolibrary.org/obo/GO_1902007 GO:1902008 biolink:BiologicalProcess negative regulation of toxin transport Any process that stops, prevents or reduces the frequency, rate or extent of toxin transport. go.json down regulation of toxin transport|down-regulation of toxin transport|downregulation of toxin transport|inhibition of toxin transport http://purl.obolibrary.org/obo/GO_1902008 GO:1902005 biolink:BiologicalProcess regulation of proline biosynthetic process Any process that modulates the frequency, rate or extent of proline biosynthetic process. go.json regulation of proline anabolism|regulation of proline biosynthesis|regulation of proline formation|regulation of proline synthesis http://purl.obolibrary.org/obo/GO_1902005 GO:1902006 biolink:BiologicalProcess negative regulation of proline biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process. go.json down regulation of proline anabolism|down regulation of proline biosynthesis|down regulation of proline biosynthetic process|down regulation of proline formation|down regulation of proline synthesis|down-regulation of proline anabolism|down-regulation of proline biosynthesis|down-regulation of proline biosynthetic process|down-regulation of proline formation|down-regulation of proline synthesis|downregulation of proline anabolism|downregulation of proline biosynthesis|downregulation of proline biosynthetic process|downregulation of proline formation|downregulation of proline synthesis|inhibition of proline anabolism|inhibition of proline biosynthesis|inhibition of proline biosynthetic process|inhibition of proline formation|inhibition of proline synthesis|negative regulation of proline anabolism|negative regulation of proline biosynthesis|negative regulation of proline formation|negative regulation of proline synthesis http://purl.obolibrary.org/obo/GO_1902006 GO:1902003 biolink:BiologicalProcess regulation of amyloid-beta formation Any process that modulates the frequency, rate or extent of amyloid-beta formation. go.json regulation of beta-amyloid formation http://purl.obolibrary.org/obo/GO_1902003 GO:0015847 biolink:BiologicalProcess putrescine transport The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. go.json http://purl.obolibrary.org/obo/GO_0015847 GO:0015848 biolink:BiologicalProcess spermidine transport The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015848 GO:1902004 biolink:BiologicalProcess positive regulation of amyloid-beta formation Any process that activates or increases the frequency, rate or extent of amyloid-beta formation. go.json activation of beta-amyloid formation|positive regulation of beta-amyloid formation|up regulation of beta-amyloid formation|up-regulation of beta-amyloid formation|upregulation of beta-amyloid formation http://purl.obolibrary.org/obo/GO_1902004 GO:1902001 biolink:BiologicalProcess fatty acid transmembrane transport The process in which a fatty acid is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902001 GO:0015849 biolink:BiologicalProcess organic acid transport The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015849 goslim_pir GO:1902002 biolink:BiologicalProcess obsolete protein phosphorylation involved in cellular protein catabolic process OBSOLETE. Any protein phosphorylation that is involved in cellular protein catabolic process. go.json protein amino acid phosphorylation involved in cellular protein breakdown|protein amino acid phosphorylation involved in cellular protein catabolic process|protein amino acid phosphorylation involved in cellular protein catabolism|protein amino acid phosphorylation involved in cellular protein degradation|protein phosphorylation involved in cellular protein breakdown|protein phosphorylation involved in cellular protein catabolism|protein phosphorylation involved in cellular protein degradation True http://purl.obolibrary.org/obo/GO_1902002 GO:0015843 biolink:BiologicalProcess methylammonium transport The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015843 GO:1902010 biolink:BiologicalProcess negative regulation of translation in response to endoplasmic reticulum stress Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. go.json down regulation of protein biosynthetic process involved in ER stress response|down regulation of protein biosynthetic process involved in response to ER stress|down regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress|down-regulation of protein biosynthetic process involved in ER stress response|down-regulation of protein biosynthetic process involved in response to ER stress|down-regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress|downregulation of protein biosynthetic process involved in ER stress response|downregulation of protein biosynthetic process involved in response to ER stress|downregulation of protein biosynthetic process involved in response to endoplasmic reticulum stress|inhibition of protein biosynthetic process involved in ER stress response|inhibition of protein biosynthetic process involved in response to ER stress|inhibition of protein biosynthetic process involved in response to endoplasmic reticulum stress|negative regulation of protein anabolism involved in ER stress response|negative regulation of protein anabolism involved in response to ER stress|negative regulation of protein anabolism involved in response to endoplasmic reticulum stress|negative regulation of protein biosynthesis involved in ER stress response|negative regulation of protein biosynthesis involved in response to ER stress|negative regulation of protein biosynthesis involved in response to endoplasmic reticulum stress|negative regulation of protein biosynthetic process involved in ER stress response|negative regulation of protein biosynthetic process involved in response to ER stress|negative regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress|negative regulation of protein formation involved in ER stress response|negative regulation of protein formation involved in response to ER stress|negative regulation of protein formation involved in response to endoplasmic reticulum stress|negative regulation of protein synthesis involved in ER stress response|negative regulation of protein synthesis involved in response to ER stress|negative regulation of protein synthesis involved in response to endoplasmic reticulum stress|negative regulation of translation involved in ER stress response|negative regulation of translation involved in response to ER stress|protein biosynthesis inhibitor activity involved in ER stress response|protein biosynthesis inhibitor activity involved in response to ER stress|protein biosynthesis inhibitor activity involved in response to endoplasmic reticulum stress|protein biosynthetic process inhibitor activity involved in ER stress response|protein biosynthetic process inhibitor activity involved in response to ER stress|protein biosynthetic process inhibitor activity involved in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1902010 GO:1902011 biolink:BiologicalProcess poly(ribitol phosphate) teichoic acid metabolic process The chemical reactions and pathways involving poly(ribitol phosphate) teichoic acid. go.json poly(ribitol phosphate) teichoic acid metabolism http://purl.obolibrary.org/obo/GO_1902011 GO:0015844 biolink:BiologicalProcess monoamine transport The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015844 GO:0015845 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015845 GO:0015846 biolink:BiologicalProcess polyamine transport The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015846 GO:0015840 biolink:BiologicalProcess urea transport The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2. go.json http://purl.obolibrary.org/obo/GO_0015840 GO:0015841 biolink:BiologicalProcess chromaffin granule amine transport The directed movement of amines into, out of or within chromaffin granules. go.json http://purl.obolibrary.org/obo/GO_0015841 GO:0015842 biolink:BiologicalProcess aminergic neurotransmitter loading into synaptic vesicle The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps. go.json http://purl.obolibrary.org/obo/GO_0015842 GO:0050250 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050250 GO:0050253 biolink:MolecularActivity retinyl-palmitate esterase activity Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. KEGG_REACTION:R02368|MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN|RHEA:21508|Reactome:R-HSA-2404133|Reactome:R-HSA-8848355|Reactome:R-HSA-975593|Reactome:R-HSA-975594 go.json retinyl ester hydrolase activity|retinyl palmitate hydrolase activity|retinyl palmitate hydrolyase activity|retinyl-palmitate palmitohydrolase activity http://purl.obolibrary.org/obo/GO_0050253 GO:0001206 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001206 GO:0050254 biolink:MolecularActivity rhodopsin kinase activity Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. EC:2.7.11.14|MetaCyc:2.7.11.14-RXN|RHEA:23356|Reactome:R-HSA-2581474 go.json GPCR kinase 1 activity|cone opsin kinase activity|opsin kinase (phosphorylating) activity|opsin kinase activity|rhodopsin kinase (phosphorylating) activity http://purl.obolibrary.org/obo/GO_0050254 GO:0001207 biolink:BiologicalProcess obsolete histone displacement OBSOLETE. The removal of histones, including histone dimers, from nucleosomes within chromatin. go.json True http://purl.obolibrary.org/obo/GO_0001207 GO:0050251 biolink:MolecularActivity retinol isomerase activity Catalysis of the reaction: all-trans-retinol = 11-cis-retinol. KEGG_REACTION:R02369|RHEA:19141|Reactome:R-HSA-2465926 go.json all-trans-retinol 11-cis-trans-isomerase activity|all-trans-retinol isomerase activity http://purl.obolibrary.org/obo/GO_0050251 GO:0001208 biolink:BiologicalProcess obsolete histone H2A-H2B dimer displacement OBSOLETE. The removal of a H2A-H2B histone dimer from a nucleosome within chromatin. go.json True http://purl.obolibrary.org/obo/GO_0001208 GO:0050252 biolink:MolecularActivity retinol O-fatty-acyltransferase activity Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. EC:2.3.1.76|MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN|RHEA:11488|Reactome:R-HSA-2465919|Reactome:R-HSA-8848585 go.json acyl-CoA:retinol O-acyltransferase activity|retinol acyltransferase activity|retinol fatty-acyltransferase activity http://purl.obolibrary.org/obo/GO_0050252 GO:0001209 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001209 GO:1990596 biolink:BiologicalProcess obsolete histone H3-K4 deacetylation OBSOLETE. The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone. go.json True http://purl.obolibrary.org/obo/GO_1990596 GO:1990597 biolink:CellularComponent AIP1-IRE1 complex A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein). go.json AIP1-ERN1 complex|IRE1-DAB2IP complex|IRE1alpha-AIP1 complex http://purl.obolibrary.org/obo/GO_1990597 GO:1990598 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990598 GO:1990599 biolink:MolecularActivity 3' overhang single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks. go.json http://purl.obolibrary.org/obo/GO_1990599 GO:1990592 biolink:BiologicalProcess protein K69-linked ufmylation A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein. go.json http://purl.obolibrary.org/obo/GO_1990592 gocheck_do_not_annotate GO:1990593 biolink:MolecularActivity nascent polypeptide-associated complex binding Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. go.json NAC binding|NACA binding http://purl.obolibrary.org/obo/GO_1990593 GO:1990594 biolink:MolecularActivity L-altrarate dehydratase activity Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O. RHEA:44028 go.json L-talarate dehydratase activity http://purl.obolibrary.org/obo/GO_1990594 GO:1990595 biolink:MolecularActivity mast cell secretagogue receptor activity Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells. go.json http://purl.obolibrary.org/obo/GO_1990595 GO:2001039 biolink:BiologicalProcess negative regulation of cellular response to drug Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to drug. go.json http://purl.obolibrary.org/obo/GO_2001039 GO:1990590 biolink:CellularComponent ATF1-ATF4 transcription factor complex Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway. go.json http://purl.obolibrary.org/obo/GO_1990590 GO:1990591 biolink:BiologicalProcess asparagine transmembrane import into vacuole The directed movement of asparagine into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_1990591 GO:2001031 biolink:BiologicalProcess positive regulation of cellular glucuronidation Any process that activates or increases the frequency, rate or extent of cellular glucuronidation. go.json positive regulation of cellular glucuronide biosynthesis|positive regulation of cellular glucuronide biosynthetic process|positive regulation of cellular glucuronoside biosynthesis|positive regulation of cellular glucuronoside biosynthetic process http://purl.obolibrary.org/obo/GO_2001031 GO:2001032 biolink:BiologicalProcess regulation of double-strand break repair via nonhomologous end joining Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining. go.json regulation of NHEJ http://purl.obolibrary.org/obo/GO_2001032 GO:2001033 biolink:BiologicalProcess negative regulation of double-strand break repair via nonhomologous end joining Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining. go.json negative regulation of NHEJ http://purl.obolibrary.org/obo/GO_2001033 GO:2001034 biolink:BiologicalProcess positive regulation of double-strand break repair via nonhomologous end joining Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining. go.json positive regulation of NHEJ http://purl.obolibrary.org/obo/GO_2001034 GO:2001035 biolink:BiologicalProcess regulation of tongue muscle cell differentiation Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001035 GO:2001036 biolink:BiologicalProcess negative regulation of tongue muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001036 GO:2001037 biolink:BiologicalProcess positive regulation of tongue muscle cell differentiation Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001037 GO:2001038 biolink:BiologicalProcess regulation of cellular response to drug Any process that modulates the frequency, rate or extent of cellular response to drug. go.json http://purl.obolibrary.org/obo/GO_2001038 GO:2001030 biolink:BiologicalProcess negative regulation of cellular glucuronidation Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation. go.json negative regulation of cellular glucuronide biosynthesis|negative regulation of cellular glucuronide biosynthetic process|negative regulation of cellular glucuronoside biosynthesis|negative regulation of cellular glucuronoside biosynthetic process http://purl.obolibrary.org/obo/GO_2001030 GO:2001042 biolink:BiologicalProcess negative regulation of septum digestion after cytokinesis Any process that stops, prevents or reduces the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. go.json negative regulation of cytokinetic cell separation http://purl.obolibrary.org/obo/GO_2001042 GO:2001043 biolink:BiologicalProcess positive regulation of septum digestion after cytokinesis Any process that activates or increases the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. go.json positive regulation of cell separation after cytokinesis|positive regulation of cytokinetic cell separation http://purl.obolibrary.org/obo/GO_2001043 GO:2001044 biolink:BiologicalProcess regulation of integrin-mediated signaling pathway Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway. go.json regulation of integrin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2001044 GO:2001045 biolink:BiologicalProcess negative regulation of integrin-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway. go.json negative regulation of integrin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2001045 GO:2001046 biolink:BiologicalProcess positive regulation of integrin-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway. go.json positive regulation of integrin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_2001046 GO:2001047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001047 GO:2001048 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001048 GO:2001049 biolink:BiologicalProcess regulation of tendon cell differentiation Any process that modulates the frequency, rate or extent of tendon cell differentiation. go.json regulation of muscle attachment cell differentiation|regulation of tenocyte differentiation http://purl.obolibrary.org/obo/GO_2001049 GO:2001040 biolink:BiologicalProcess positive regulation of cellular response to drug Any process that activates or increases the frequency, rate or extent of cellular response to drug. go.json http://purl.obolibrary.org/obo/GO_2001040 GO:2001041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001041 GO:2001053 biolink:BiologicalProcess regulation of mesenchymal cell apoptotic process Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. go.json regulation of mesenchymal cell apoptosis http://purl.obolibrary.org/obo/GO_2001053 GO:2001054 biolink:BiologicalProcess negative regulation of mesenchymal cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. go.json negative regulation of mesenchymal cell apoptosis http://purl.obolibrary.org/obo/GO_2001054 GO:2001055 biolink:BiologicalProcess positive regulation of mesenchymal cell apoptotic process Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. go.json positive regulation of mesenchymal cell apoptosis http://purl.obolibrary.org/obo/GO_2001055 GO:2001056 biolink:BiologicalProcess positive regulation of cysteine-type endopeptidase activity Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity. go.json positive regulation of lysosomal cysteine-type endopeptidase|positive regulation of thiol endopeptidase activity http://purl.obolibrary.org/obo/GO_2001056 gocheck_do_not_annotate GO:2001057 biolink:BiologicalProcess reactive nitrogen species metabolic process The chemical reactions and pathways involving a reactive nitrogen species. go.json RNS metabolic process|RNS metabolism|reactive nitrogen species metabolism http://purl.obolibrary.org/obo/GO_2001057 GO:2001058 biolink:BiologicalProcess D-tagatose 6-phosphate metabolic process The chemical reactions and pathways involving a D-tagatose 6-phosphate. go.json D-tagatose 6-phosphate metabolism http://purl.obolibrary.org/obo/GO_2001058 GO:2001059 biolink:BiologicalProcess D-tagatose 6-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate. UniPathway:UPA00704 go.json D-tagatose 6-phosphate catabolism http://purl.obolibrary.org/obo/GO_2001059 GO:2001050 biolink:BiologicalProcess negative regulation of tendon cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation. go.json negative regulation of muscle attachment cell differentiation|negative regulation of tenocyte differentiation http://purl.obolibrary.org/obo/GO_2001050 GO:2001051 biolink:BiologicalProcess positive regulation of tendon cell differentiation Any process that activates or increases the frequency, rate or extent of tendon cell differentiation. go.json positive regulation of muscle attachment cell differentiation|positive regulation of tenocyte differentiation http://purl.obolibrary.org/obo/GO_2001051 GO:2001052 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001052 GO:2001064 biolink:MolecularActivity cellooligosaccharide binding Binding to cellooligosaccharide. go.json http://purl.obolibrary.org/obo/GO_2001064 GO:2001065 biolink:MolecularActivity mannan binding Binding to mannan. go.json mannoglycan binding http://purl.obolibrary.org/obo/GO_2001065 GO:2001066 biolink:MolecularActivity amylopectin binding Binding to amylopectin. go.json http://purl.obolibrary.org/obo/GO_2001066 GO:2001067 biolink:MolecularActivity pullulan binding Binding to pullulan. go.json http://purl.obolibrary.org/obo/GO_2001067 GO:2001068 biolink:MolecularActivity arabinoxylan binding Binding to arabinoxylan. go.json http://purl.obolibrary.org/obo/GO_2001068 GO:2001069 biolink:MolecularActivity glycogen binding Binding to glycogen. go.json animal starch binding|liver starch binding http://purl.obolibrary.org/obo/GO_2001069 GO:2001060 biolink:BiologicalProcess D-glycero-D-manno-heptose 7-phosphate metabolic process The chemical reactions and pathways involving a D-glycero-D-manno-heptose 7-phosphate. go.json D-glycero-D-manno-heptose 7-phosphate metabolism http://purl.obolibrary.org/obo/GO_2001060 GO:2001061 biolink:BiologicalProcess D-glycero-D-manno-heptose 7-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate. UniPathway:UPA00041 go.json D-glycero-D-manno-heptose 7-phosphate biosynthesis http://purl.obolibrary.org/obo/GO_2001061 GO:2001062 biolink:MolecularActivity xylan binding Binding to xylan. go.json http://purl.obolibrary.org/obo/GO_2001062 GO:2001063 biolink:MolecularActivity glucomannan binding Binding to glucomannan. go.json http://purl.obolibrary.org/obo/GO_2001063 GO:1990552 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990552 GO:1990553 biolink:BiologicalProcess mitochondrial 5'-adenylyl sulfate transmembrane transport The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990553 GO:1990554 biolink:BiologicalProcess mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990554 GO:1990555 biolink:BiologicalProcess mitochondrial oxaloacetate transmembrane transport The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990555 GO:1990550 biolink:BiologicalProcess mitochondrial alpha-ketoglutarate transmembrane transport The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json mitochondrial 2-oxoglutarate transmembrane transport http://purl.obolibrary.org/obo/GO_1990550 GO:1990551 biolink:BiologicalProcess mitochondrial 2-oxoadipate transmembrane transport The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990551 GO:1990556 biolink:BiologicalProcess mitochondrial isopropylmalate transmembrane transport The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990556 GO:1990557 biolink:BiologicalProcess mitochondrial sulfate transmembrane transport The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990557 GO:1990558 biolink:BiologicalProcess mitochondrial malonate(1-) transmembrane transport The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990558 GO:1990559 biolink:BiologicalProcess mitochondrial coenzyme A transmembrane transport The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990559 GO:1990563 biolink:CellularComponent extracellular exosome complex A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome. go.json exosome complex|extracellular vesicular exosome complex http://purl.obolibrary.org/obo/GO_1990563 GO:1990564 biolink:BiologicalProcess protein polyufmylation Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain. go.json http://purl.obolibrary.org/obo/GO_1990564 gocheck_do_not_annotate GO:1990565 biolink:CellularComponent HSP90-CDC37 chaperone complex A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins. go.json http://purl.obolibrary.org/obo/GO_1990565 GO:1990566 biolink:CellularComponent I(KACh) inward rectifier potassium channel complex An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signaling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits. go.json GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex|Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex|muscarinic potassium channel complex http://purl.obolibrary.org/obo/GO_1990566 GO:1990560 biolink:MolecularActivity obsolete DNA methyltransferase binding OBSOLETE. Binding to a DNA methyltransferase. go.json DNA methyltransferase binding True http://purl.obolibrary.org/obo/GO_1990560 GO:1990561 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion starvation OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions. go.json True http://purl.obolibrary.org/obo/GO_1990561 GO:1990562 biolink:CellularComponent syndecan-syntenin-ALIX complex An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery. go.json exosome complex http://purl.obolibrary.org/obo/GO_1990562 GO:2001006 biolink:BiologicalProcess regulation of cellulose biosynthetic process Any process that modulates the frequency, rate or extent of cellulose biosynthetic process. go.json regulation of cellulose anabolism|regulation of cellulose biosynthesis|regulation of cellulose formation|regulation of cellulose synthesis http://purl.obolibrary.org/obo/GO_2001006 GO:2001007 biolink:BiologicalProcess negative regulation of cellulose biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process. go.json negative regulation of cellulose anabolism|negative regulation of cellulose biosynthesis|negative regulation of cellulose formation|negative regulation of cellulose synthesis http://purl.obolibrary.org/obo/GO_2001007 GO:2001008 biolink:BiologicalProcess positive regulation of cellulose biosynthetic process Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process. go.json positive regulation of cellulose anabolism|positive regulation of cellulose biosynthesis|positive regulation of cellulose formation|positive regulation of cellulose synthesis http://purl.obolibrary.org/obo/GO_2001008 GO:2001009 biolink:BiologicalProcess regulation of plant-type cell wall cellulose biosynthetic process Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. go.json regulation of cell wall cellulose biosynthesis|regulation of cellulose biosynthesis during cell wall biosynthesis http://purl.obolibrary.org/obo/GO_2001009 GO:2001000 biolink:BiologicalProcess regulation of xylan catabolic process Any process that modulates the frequency, rate or extent of xylan catabolic process. go.json regulation of xylan breakdown|regulation of xylan catabolism|regulation of xylan degradation http://purl.obolibrary.org/obo/GO_2001000 GO:2001001 biolink:BiologicalProcess negative regulation of xylan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process. go.json negative regulation of xylan breakdown|negative regulation of xylan catabolism|negative regulation of xylan degradation http://purl.obolibrary.org/obo/GO_2001001 GO:2001002 biolink:BiologicalProcess positive regulation of xylan catabolic process Any process that activates or increases the frequency, rate or extent of xylan catabolic process. go.json positive regulation of xylan breakdown|positive regulation of xylan catabolism|positive regulation of xylan degradation http://purl.obolibrary.org/obo/GO_2001002 GO:2001003 biolink:BiologicalProcess regulation of pectin catabolic process Any process that modulates the frequency, rate or extent of pectin catabolic process. go.json regulation of pectin breakdown|regulation of pectin catabolism|regulation of pectin degradation http://purl.obolibrary.org/obo/GO_2001003 GO:2001004 biolink:BiologicalProcess negative regulation of pectin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process. go.json negative regulation of pectin breakdown|negative regulation of pectin catabolism|negative regulation of pectin degradation http://purl.obolibrary.org/obo/GO_2001004 GO:2001005 biolink:BiologicalProcess positive regulation of pectin catabolic process Any process that activates or increases the frequency, rate or extent of pectin catabolic process. go.json positive regulation of pectin breakdown|positive regulation of pectin catabolism|positive regulation of pectin degradation http://purl.obolibrary.org/obo/GO_2001005 GO:1990567 biolink:CellularComponent DPS complex A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22. go.json http://purl.obolibrary.org/obo/GO_1990567 GO:1990568 biolink:CellularComponent obsolete MIS18 complex OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly. go.json MIS18 complex True http://purl.obolibrary.org/obo/GO_1990568 GO:1990569 biolink:BiologicalProcess UDP-N-acetylglucosamine transmembrane transport The process in which UDP-N-acetylglucosamine is transported across a membrane. go.json UDP-N-acetylglucosamine transport http://purl.obolibrary.org/obo/GO_1990569 GO:1990574 biolink:CellularComponent meiotic spindle astral microtubule Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. go.json http://purl.obolibrary.org/obo/GO_1990574 GO:1990575 biolink:BiologicalProcess mitochondrial L-ornithine transmembrane transport The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json mitochondrial ornithine transmembrane transport|mitochondrial ornithine transport http://purl.obolibrary.org/obo/GO_1990575 GO:1990576 biolink:MolecularActivity G protein-coupled glucose receptor activity Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G-protein coupled glucose receptor activity http://purl.obolibrary.org/obo/GO_1990576 GO:1990577 biolink:BiologicalProcess C-terminal protein demethylation The removal of a methyl group from the C-terminal amino acid of a protein. go.json http://purl.obolibrary.org/obo/GO_1990577 gocheck_do_not_annotate GO:1990570 biolink:BiologicalProcess GDP-mannose transmembrane transport The process in which GDP-mannose is transported across a membrane. go.json GDP-mannose transport http://purl.obolibrary.org/obo/GO_1990570 GO:1990571 biolink:BiologicalProcess meiotic centromere clustering The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I. go.json centromere clustering during meiosis|homologous chromosome movement towards spindle pole in meiosis I prometaphase http://purl.obolibrary.org/obo/GO_1990571 GO:1990572 biolink:CellularComponent TERT-RMRP complex A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP). go.json telomerase reverse transcriptase:RMRP RNA complex http://purl.obolibrary.org/obo/GO_1990572 GO:1990573 biolink:BiologicalProcess potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. go.json potassium import|potassium ion import|potassium ion uptake http://purl.obolibrary.org/obo/GO_1990573 GO:2001017 biolink:BiologicalProcess regulation of retrograde axon cargo transport Any process that modulates the frequency, rate or extent of retrograde axon cargo transport. go.json regulation of retrograde axonal transport http://purl.obolibrary.org/obo/GO_2001017 GO:2001018 biolink:BiologicalProcess negative regulation of retrograde axon cargo transport Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport. go.json negative regulation of retrograde axonal transport http://purl.obolibrary.org/obo/GO_2001018 GO:2001019 biolink:BiologicalProcess positive regulation of retrograde axon cargo transport Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport. go.json positive regulation of retrograde axonal transport http://purl.obolibrary.org/obo/GO_2001019 GO:2001010 biolink:BiologicalProcess negative regulation of plant-type cell wall cellulose biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. go.json negative regulation of cell wall cellulose biosynthesis|negative regulation of cellulose biosynthesis during cell wall biosynthesis http://purl.obolibrary.org/obo/GO_2001010 GO:2001011 biolink:BiologicalProcess positive regulation of plant-type cell wall cellulose biosynthetic process Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. go.json positive regulation of cell wall cellulose biosynthesis|positive regulation of cellulose biosynthesis during cell wall biosynthesis http://purl.obolibrary.org/obo/GO_2001011 GO:2001012 biolink:BiologicalProcess mesenchymal cell differentiation involved in renal system development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. go.json mesenchymal cell differentiation involved in urinary system development|mesenchymal cell differentiation involved in urinary tract development http://purl.obolibrary.org/obo/GO_2001012 GO:2001013 biolink:BiologicalProcess epithelial cell proliferation involved in renal tubule morphogenesis Any epithelial cell proliferation that is involved in renal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2001013 GO:2001014 biolink:BiologicalProcess regulation of skeletal muscle cell differentiation Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001014 GO:2001015 biolink:BiologicalProcess negative regulation of skeletal muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001015 GO:2001016 biolink:BiologicalProcess positive regulation of skeletal muscle cell differentiation Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001016 GO:1990578 biolink:CellularComponent perinuclear endoplasmic reticulum membrane The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. go.json perinuclear ER membrane http://purl.obolibrary.org/obo/GO_1990578 GO:1990579 biolink:BiologicalProcess peptidyl-serine trans-autophosphorylation The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer. go.json serine autophosphorylation in trans|serine transautophosphorylation http://purl.obolibrary.org/obo/GO_1990579 gocheck_do_not_annotate GO:1990585 biolink:MolecularActivity hydroxyproline O-arabinosyltransferase activity Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+. go.json HPAT http://purl.obolibrary.org/obo/GO_1990585 GO:1990586 biolink:CellularComponent divisome complex A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells. go.json http://purl.obolibrary.org/obo/GO_1990586 GO:1990587 biolink:CellularComponent FtsQBL complex A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ. go.json FtsB-FtsL-FtsQ complex http://purl.obolibrary.org/obo/GO_1990587 GO:1990588 biolink:CellularComponent FtsBL complex A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL. go.json FtsB-FtsL complex http://purl.obolibrary.org/obo/GO_1990588 GO:1990581 biolink:BiologicalProcess obsolete lysosome lysis OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause. go.json lysosomal lysis|lysosome lysis True http://purl.obolibrary.org/obo/GO_1990581 GO:1990582 biolink:MolecularActivity obsolete intracellular membrane-bounded organelle binding OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle. go.json intracellular membrane-bounded organelle binding|intracellular membrane-enclosed organelle binding True http://purl.obolibrary.org/obo/GO_1990582 GO:1990583 biolink:MolecularActivity phospholipase D activator activity Binds to and increases the activity of the enzyme phospholipase D. go.json http://purl.obolibrary.org/obo/GO_1990583 GO:1990584 biolink:CellularComponent cardiac Troponin complex A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction. go.json cTnC:cTnI:cTnT http://purl.obolibrary.org/obo/GO_1990584 GO:2001028 biolink:BiologicalProcess positive regulation of endothelial cell chemotaxis Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2001028 GO:2001029 biolink:BiologicalProcess regulation of cellular glucuronidation Any process that modulates the frequency, rate or extent of cellular glucuronidation. go.json regulation of cellular glucuronide biosynthesis|regulation of cellular glucuronide biosynthetic process|regulation of cellular glucuronoside biosynthesis|regulation of cellular glucuronoside biosynthetic process http://purl.obolibrary.org/obo/GO_2001029 GO:1990580 biolink:BiologicalProcess regulation of cytoplasmic translational termination Any process that modulates the frequency, rate or extent of cytoplasmic translational termination. go.json http://purl.obolibrary.org/obo/GO_1990580 GO:2001020 biolink:BiologicalProcess obsolete regulation of response to DNA damage stimulus OBSOLETE. Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. go.json regulation of DNA damage response|regulation of cellular DNA damage response|regulation of cellular response to DNA damage stimulus|regulation of response to genotoxic stress True http://purl.obolibrary.org/obo/GO_2001020 GO:2001021 biolink:BiologicalProcess obsolete negative regulation of response to DNA damage stimulus OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. go.json negative regulation of DNA damage response|negative regulation of cellular DNA damage response|negative regulation of cellular response to DNA damage stimulus|negative regulation of response to genotoxic stress True http://purl.obolibrary.org/obo/GO_2001021 GO:2001022 biolink:BiologicalProcess obsolete positive regulation of response to DNA damage stimulus OBSOLETE. Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. go.json positive regulation of DNA damage response|positive regulation of cellular DNA damage response|positive regulation of cellular response to DNA damage stimulus|positive regulation of response to genotoxic stress True http://purl.obolibrary.org/obo/GO_2001022 GO:2001023 biolink:BiologicalProcess regulation of response to drug Any process that modulates the frequency, rate or extent of response to drug. go.json regulation of drug resistance|regulation of drug susceptibility/resistance http://purl.obolibrary.org/obo/GO_2001023 GO:2001024 biolink:BiologicalProcess negative regulation of response to drug Any process that stops, prevents or reduces the frequency, rate or extent of response to drug. go.json negative regulation of drug resistance|negative regulation of drug susceptibility/resistance http://purl.obolibrary.org/obo/GO_2001024 GO:2001025 biolink:BiologicalProcess positive regulation of response to drug Any process that activates or increases the frequency, rate or extent of response to drug. go.json positive regulation of drug resistance|positive regulation of drug susceptibility/resistance http://purl.obolibrary.org/obo/GO_2001025 GO:2001026 biolink:BiologicalProcess regulation of endothelial cell chemotaxis Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2001026 GO:2001027 biolink:BiologicalProcess negative regulation of endothelial cell chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_2001027 GO:1990589 biolink:CellularComponent ATF4-CREB1 transcription factor complex Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway. go.json http://purl.obolibrary.org/obo/GO_1990589 GO:1990510 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990510 GO:1990511 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990511 GO:1990516 biolink:BiologicalProcess ribonucleotide excision repair The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase. go.json http://purl.obolibrary.org/obo/GO_1990516 GO:1990517 biolink:BiologicalProcess obsolete protein localization to photoreceptor outer segment OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium. go.json True http://purl.obolibrary.org/obo/GO_1990517 GO:1990518 biolink:MolecularActivity single-stranded 3'-5' DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'. go.json http://purl.obolibrary.org/obo/GO_1990518 GO:1990519 biolink:BiologicalProcess pyrimidine nucleotide import into mitochondrion The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix. go.json mitochondrial pyrimidine nucleotide import http://purl.obolibrary.org/obo/GO_1990519 GO:1990512 biolink:CellularComponent Cry-Per complex Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms. go.json http://purl.obolibrary.org/obo/GO_1990512 GO:1990513 biolink:CellularComponent CLOCK-BMAL transcription complex Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. go.json CLOCK/BMAL complex http://purl.obolibrary.org/obo/GO_1990513 GO:1990514 biolink:BiologicalProcess 5' transitive RNA interference An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA. go.json http://purl.obolibrary.org/obo/GO_1990514 GO:1990515 biolink:BiologicalProcess 3' transitive RNA interference An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA. go.json http://purl.obolibrary.org/obo/GO_1990515 GO:1990520 biolink:CellularComponent separase-securin complex A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC). go.json Cut1-2 complex http://purl.obolibrary.org/obo/GO_1990520 GO:1990521 biolink:MolecularActivity obsolete m7G(5')pppN diphosphatase activator activity OBSOLETE. Binds to and increases the activity of m7G(5')pppN diphosphatase. go.json True http://purl.obolibrary.org/obo/GO_1990521 GO:1990522 biolink:BiologicalProcess tail spike morphogenesis The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death. WBbt:0006979|WBbt:0008072 go.json http://purl.obolibrary.org/obo/GO_1990522 GO:1990527 biolink:CellularComponent Tec1p-Ste12p-Dig1p complex A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_1990527 GO:1990528 biolink:CellularComponent Rvs161p-Rvs167p complex A protein complex that is involved in endocytosis in the yeast S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_1990528 GO:1990529 biolink:CellularComponent glycosylphosphatidylinositol-mannosyltransferase I complex A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M. go.json GPI-MT-I complex http://purl.obolibrary.org/obo/GO_1990529 GO:1990523 biolink:BiologicalProcess bone regeneration The regrowth of bone following its loss or destruction. go.json http://purl.obolibrary.org/obo/GO_1990523 GO:1990524 biolink:CellularComponent INA complex A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p. go.json INAC http://purl.obolibrary.org/obo/GO_1990524 GO:1990525 biolink:MolecularActivity BIR domain binding Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain. go.json Baculovirus Inhibitor of apoptosis protein Repeat domain binding http://purl.obolibrary.org/obo/GO_1990525 GO:1990526 biolink:CellularComponent Ste12p-Dig1p-Dig2p complex A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_1990526 GO:1990530 biolink:CellularComponent Cdc50p-Drs2p complex A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome. go.json http://purl.obolibrary.org/obo/GO_1990530 GO:1990531 biolink:CellularComponent phospholipid-translocating ATPase complex A protein complex that functions as a phospholipid-translocating P-Type ATPase. go.json APLT complex|CDC50-DRS2 complex|CRF1-DNF3 complex|DNF3-CRF1 complex|DRS2-CDC50 complex|Dnf1-Lem3 complex|Dnf2-Lem3 complex|Lem3-Dnf1 complex|Lem3p-Dnf1p complex|P4-ATPase complex|aminophospholipid translocase complex|phospholipid flippase complex http://purl.obolibrary.org/obo/GO_1990531 GO:1990532 biolink:BiologicalProcess stress response to nickel ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus. go.json response to nickel ion stress|response to nickel toxicity|stress response to nickel http://purl.obolibrary.org/obo/GO_1990532 GO:1990533 biolink:CellularComponent Dom34-Hbs1 complex A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay. go.json Dom34:Hbs1 complex http://purl.obolibrary.org/obo/GO_1990533 GO:1990538 biolink:MolecularActivity xylan O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan. go.json http://purl.obolibrary.org/obo/GO_1990538 GO:1990539 biolink:BiologicalProcess fructose import across plasma membrane The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol. go.json fructose import|fructose uptake http://purl.obolibrary.org/obo/GO_1990539 GO:1990534 biolink:MolecularActivity thermospermine oxidase activity Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine. go.json http://purl.obolibrary.org/obo/GO_1990534 GO:1990535 biolink:BiologicalProcess neuron projection maintenance The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. go.json axon homeostasis|axon maintenance|neurite maintenance|neuron process maintenance|neuron protrusion maintenance|neuronal cell projection maintenance http://purl.obolibrary.org/obo/GO_1990535 GO:1990536 biolink:BiologicalProcess phosphoenolpyruvate transmembrane import into Golgi lumen The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane. go.json http://purl.obolibrary.org/obo/GO_1990536 GO:1990537 biolink:CellularComponent mitotic spindle polar microtubule Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone. go.json http://purl.obolibrary.org/obo/GO_1990537 GO:1990541 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990541 GO:1990542 biolink:BiologicalProcess mitochondrial transmembrane transport The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990542 GO:1990543 biolink:BiologicalProcess mitochondrial S-adenosyl-L-methionine transmembrane transport The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990543 GO:1990544 biolink:BiologicalProcess mitochondrial ATP transmembrane transport The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990544 GO:1990540 biolink:BiologicalProcess mitochondrial manganese ion transmembrane transport The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990540 GO:1990549 biolink:BiologicalProcess mitochondrial NAD transmembrane transport The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990549 GO:1990545 biolink:BiologicalProcess mitochondrial thiamine pyrophosphate transmembrane transport The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990545 GO:1990546 biolink:BiologicalProcess mitochondrial tricarboxylic acid transmembrane transport The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990546 OIO:hasAlternativeId biolink:OntologyClass has_alternative_id go.json http://www.geneontology.org/formats/oboInOwl#hasAlternativeId GO:1990547 biolink:BiologicalProcess mitochondrial phosphate ion transmembrane transport The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990547 GO:1990548 biolink:BiologicalProcess mitochondrial FAD transmembrane transport The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_1990548 GO:1990500 biolink:CellularComponent eif4e-cup complex A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo. go.json eukaryotic translation initiation factor 4E-cup complex http://purl.obolibrary.org/obo/GO_1990500 GO:1990509 biolink:CellularComponent PYM-mago-Y14 complex Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans. go.json PYM-mago-RNA-binding protein 8A complex|wibg-mago-tsu complex http://purl.obolibrary.org/obo/GO_1990509 GO:1990505 biolink:BiologicalProcess mitotic DNA replication maintenance of fidelity Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication. go.json maintenance of fidelity involved in mitotic DNA replication|maintenance of fidelity involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1990505 GO:1990506 biolink:BiologicalProcess mitotic DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle. go.json mitotic DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_1990506 GO:1990507 biolink:BiologicalProcess obsolete ATP-independent chaperone mediated protein folding OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis. go.json True http://purl.obolibrary.org/obo/GO_1990507 GO:1990508 biolink:CellularComponent CKM complex Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8. go.json CDK8 kinase module|SRB8-SRB11 complex|SRB8/9/10/11 complex http://purl.obolibrary.org/obo/GO_1990508 GO:1990501 biolink:CellularComponent exon-exon junction subcomplex mago-y14 Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA. go.json MGN-RBM8A complex|exon junction subcomplex MAGOH-Y14|mago-y14 complex http://purl.obolibrary.org/obo/GO_1990501 GO:1990502 biolink:BiologicalProcess dense core granule maturation Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. go.json dense core vesicle maturation http://purl.obolibrary.org/obo/GO_1990502 GO:1990503 biolink:CellularComponent dendritic lamellar body A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions. go.json DLB http://purl.obolibrary.org/obo/GO_1990503 GO:1990504 biolink:BiologicalProcess dense core granule exocytosis The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels. go.json dense core vesicle exocytosis http://purl.obolibrary.org/obo/GO_1990504 GO:0050389 biolink:MolecularActivity uronolactonase activity Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate. EC:3.1.1.19|MetaCyc:URONOLACTONASE-RXN|RHEA:13337 go.json D-glucurono-6,2-lactone lactonohydrolase activity|glucuronolactonase activity http://purl.obolibrary.org/obo/GO_0050389 GO:0001411 biolink:CellularComponent hyphal tip The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation. go.json http://purl.obolibrary.org/obo/GO_0001411 goslim_candida GO:0050387 biolink:MolecularActivity urethanase activity Catalysis of the reaction: H2O + H+ + urethane = CO2 + ethanol + NH4. EC:3.5.1.75|KEGG_REACTION:R02359|MetaCyc:URETHANASE-RXN|RHEA:21372 go.json urethane amidohydrolase (decarboxylating)|urethane hydrolase activity http://purl.obolibrary.org/obo/GO_0050387 GO:0050388 biolink:MolecularActivity uronate dehydrogenase activity Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH. EC:1.1.1.203|KEGG_REACTION:R01981|MetaCyc:URONATE-DEHYDROGENASE-RXN|RHEA:22404 go.json uronate: NAD-oxidoreductase activity|uronate:NAD+ 1-oxidoreductase activity|uronic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050388 GO:0001410 biolink:BiologicalProcess chlamydospore formation The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans. go.json chlamydospore development http://purl.obolibrary.org/obo/GO_0001410 GO:0050381 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050381 GO:0050382 biolink:MolecularActivity uracil-5-carboxylate decarboxylase activity Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil. EC:4.1.1.66|KEGG_REACTION:R00973|MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN|RHEA:17685 go.json uracil-5-carboxylate carboxy-lyase (uracil-forming)|uracil-5-carboxylate carboxy-lyase activity|uracil-5-carboxylic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0050382 GO:0050380 biolink:MolecularActivity undecaprenyl-diphosphatase activity Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. EC:3.6.1.27|KEGG_REACTION:R05627|MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN|RHEA:28094 go.json C(55)-isoprenyl diphosphatase activity|C(55)-isoprenyl pyrophosphatase activity|C55-isoprenyl diphosphatase activity|C55-isoprenyl pyrophosphatase activity|isoprenyl pyrophosphatase activity|undecaprenyl-diphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050380 GO:0050385 biolink:MolecularActivity ureidoglycolate lyase activity Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. EC:4.3.2.3|KEGG_REACTION:R00776|MetaCyc:UREIDOGLYCOLATE-LYASE-RXN|RHEA:11304 go.json (S)-ureidoglycolate urea-lyase (glyoxylate-forming)|(S)-ureidoglycolate urea-lyase activity|ureidoglycolase activity|ureidoglycolatase activity|ureidoglycolate hydrolase activity http://purl.obolibrary.org/obo/GO_0050385 GO:0050386 biolink:MolecularActivity ureidosuccinase activity Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4. EC:3.5.1.7|KEGG_REACTION:R00484|MetaCyc:UREIDOSUCCINASE-RXN|RHEA:14365 go.json N-carbamoyl-L-aspartate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050386 GO:0050383 biolink:MolecularActivity uracil dehydrogenase activity Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor. EC:1.17.99.4|MetaCyc:URACIL-DEHYDROGENASE-RXN|RHEA:22752 go.json http://purl.obolibrary.org/obo/GO_0050383 GO:0050384 biolink:MolecularActivity urate-ribonucleotide phosphorylase activity Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H+ + urate. EC:2.4.2.16|KEGG_REACTION:R02646|MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN|RHEA:13909 go.json UAR phosphorylase activity|urate-ribonucleotide:phosphate D-ribosyltransferase activity|urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0050384 GO:0050398 biolink:MolecularActivity wax-ester hydrolase activity Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate. EC:3.1.1.50|MetaCyc:WAX-ESTER-HYDROLASE-RXN|RHEA:13577 go.json WEH|jojoba wax esterase|wax-ester acylhydrolase activity http://purl.obolibrary.org/obo/GO_0050398 GO:0050399 biolink:MolecularActivity xanthommatin reductase activity Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = H+ + NADH + xanthommatin. EC:1.3.1.41|KEGG_REACTION:R03787|MetaCyc:XANTHOMMATIN-REDUCTASE-RXN|RHEA:13417 go.json 5,12-dihydroxanthommatin:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050399 GO:0050392 biolink:MolecularActivity vicianin beta-glucosidase activity Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose. EC:3.2.1.119|KEGG_REACTION:R03642|MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN|RHEA:14041 go.json (R)-vicianin beta-D-glucohydrolase activity|vicianin b-glucosidase activity|vicianin hydrolase activity http://purl.obolibrary.org/obo/GO_0050392 GO:0050393 biolink:MolecularActivity vinylacetyl-CoA delta-isomerase activity Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA. EC:5.3.3.3|KEGG_REACTION:R03031|MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN|RHEA:10572 go.json delta3-cis-delta2-trans-enoyl-CoA isomerase|vinylacetyl coenzyme A delta-isomerase activity|vinylacetyl coenzyme A isomerase activity|vinylacetyl-CoA D-isomerase activity|vinylacetyl-CoA delta3-delta2-isomerase activity http://purl.obolibrary.org/obo/GO_0050393 GO:0050390 biolink:MolecularActivity valine decarboxylase activity Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2. EC:4.1.1.14|KEGG_REACTION:R01437|MetaCyc:VALINE-DECARBOXYLASE-RXN|RHEA:18989|UM-BBD_reactionID:r1052 go.json L-valine carboxy-lyase (2-methylpropanamine-forming)|L-valine carboxy-lyase activity|leucine decarboxylase activity http://purl.obolibrary.org/obo/GO_0050390 GO:0050391 biolink:MolecularActivity valine dehydrogenase (NADP) activity Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH. EC:1.4.1.8|MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN|RHEA:11156 go.json L-valine:NADP+ oxidoreductase (deaminating)|valine dehydrogenase (NADP+) activity|valine dehydrogenase (nicotinanide adenine dinucleotide phosphate) http://purl.obolibrary.org/obo/GO_0050391 GO:0050396 biolink:MolecularActivity vomifoliol 4'-dehydrogenase activity Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH. EC:1.1.1.221|KEGG_REACTION:R04412|MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN|RHEA:22804 go.json vomifoliol:NAD+ 4'-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050396 GO:0050397 biolink:MolecularActivity Watasenia-luciferin 2-monooxygenase activity Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light. EC:1.13.12.8|MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN|RHEA:18057 go.json Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)|Watasenia-type luciferase activity|luciferase activity http://purl.obolibrary.org/obo/GO_0050397 GO:0050394 biolink:MolecularActivity viomycin kinase activity Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin. EC:2.7.1.103|MetaCyc:VIOMYCIN-KINASE-RXN|RHEA:20509 go.json ATP:viomycin O-phosphotransferase activity|capreomycin phosphotransferase activity|viomycin phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050394 GO:0050395 biolink:MolecularActivity vitexin beta-glucosyltransferase activity Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside. EC:2.4.1.105|KEGG_REACTION:R03565|MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:21956 go.json UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity|UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity|vitexin b-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050395 GO:0001400 biolink:CellularComponent mating projection base The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. go.json base of shmoo tip|conjugation tube base http://purl.obolibrary.org/obo/GO_0001400 GO:0001401 biolink:CellularComponent SAM complex A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex. go.json TOB complex|mitochondrial sorting and assembly machinery complex http://purl.obolibrary.org/obo/GO_0001401 GO:0001402 biolink:BiologicalProcess signal transduction involved in filamentous growth Relaying of environmental signals promoting filamentous growth. go.json MAPKKK cascade (pseudohyphal growth)|signal transduction during filamentous growth http://purl.obolibrary.org/obo/GO_0001402 GO:0001403 biolink:BiologicalProcess invasive growth in response to glucose limitation A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae. go.json colony morphology http://purl.obolibrary.org/obo/GO_0001403 goslim_yeast GO:0001408 biolink:BiologicalProcess guanine nucleotide transport The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0001408 GO:0001409 biolink:MolecularActivity guanine nucleotide transmembrane transporter activity Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0001409 GO:0001404 biolink:BiologicalProcess obsolete invasive growth OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. go.json invasive growth|tissue invasion True http://purl.obolibrary.org/obo/GO_0001404 GO:0001405 biolink:CellularComponent PAM complex, Tim23 associated import motor Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix. go.json PAM complex|mitochondrial import motor|pre-sequence translocase-associated import motor|presequence translocase-associated import motor http://purl.obolibrary.org/obo/GO_0001405 GO:0001406 biolink:MolecularActivity glycerophosphodiester transmembrane transporter activity Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. go.json http://purl.obolibrary.org/obo/GO_0001406 GO:0001407 biolink:BiologicalProcess glycerophosphodiester transmembrane transport The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. go.json http://purl.obolibrary.org/obo/GO_0001407 GO:0050301 biolink:MolecularActivity streptomycin-6-phosphatase activity Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin. EC:3.1.3.39|KEGG_REACTION:R02228|MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN|RHEA:10688 go.json streptomycin 6-phosphate phosphatase activity|streptomycin 6-phosphate phosphohydrolase activity|streptomycin-6-P phosphohydrolase activity|streptomycin-6-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050301 GO:0050302 biolink:MolecularActivity indole-3-acetaldehyde oxidase activity Catalysis of the reaction: (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 + H+. EC:1.2.3.7|KEGG_REACTION:R02681|MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN|RHEA:16277 go.json (indol-3-yl)acetaldehyde:oxygen oxidoreductase activity|AO1|IAA oxidase activity|IAAld oxidase activity|indole-3-acetaldehyde:oxygen oxidoreductase activity|indoleacetaldehyde oxidase activity http://purl.obolibrary.org/obo/GO_0050302 GO:0050300 biolink:MolecularActivity aminoglycoside 6-kinase activity Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 6-phosphate. EC:2.7.1.72|KEGG_REACTION:R02225|MetaCyc:STREPTOMYCIN-6-KINASE-RXN|RHEA:22268 go.json APH(6) activity|ATP:streptomycin 6-phosphotransferase activity|SM 6-kinase activity|streptidine kinase (phosphorylating)|streptidine kinase activity|streptomycin 6-O-phosphotransferase activity|streptomycin 6-kinase (phosphorylating)|streptomycin 6-kinase activity|streptomycin 6-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050300 GO:0050305 biolink:MolecularActivity strombine dehydrogenase activity Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H2O + NAD+ = glycine + H+ + NADH + pyruvate. EC:1.5.1.22|KEGG_REACTION:R00368|MetaCyc:STROMBINE-DEHYDROGENASE-RXN|RHEA:14061 go.json N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity|N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)|strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050305 GO:0050306 biolink:MolecularActivity sucrose 1F-fructosyltransferase activity Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose. EC:2.4.1.99|MetaCyc:RXN-1781|RHEA:23312 go.json SST activity|sucrose 1(F)-fructosyltransferase activity|sucrose-sucrose 1-fructosyltransferase activity|sucrose:sucrose 1'-beta-D-fructosyltransferase activity|sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity|sucrose:sucrose 1-fructosyltransferase activity|sucrose:sucrose 1F-beta-D-fructosyltransferase activity|sucrose:sucrose fructosyltransferase activity http://purl.obolibrary.org/obo/GO_0050306 GO:0050303 biolink:MolecularActivity lysine 6-dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine. EC:1.4.1.18|MetaCyc:LYSINE-6-DEHYDROGENASE-RXN|MetaCyc:PWY-5314|RHEA:12408 go.json L-lysine 6-dehydrogenase activity|L-lysine epsilon-dehydrogenase activity|L-lysine:NAD+ 6-oxidoreductase (deaminating)|LysDH activity http://purl.obolibrary.org/obo/GO_0050303 GO:0050304 biolink:MolecularActivity nitrous-oxide reductase activity Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide. EC:1.7.2.4|KEGG_REACTION:R02804|MetaCyc:RXN-12130|RHEA:43108 go.json N2O reductase activity|nitrogen:(acceptor) oxidoreductase (N2O-forming)|nitrogen:acceptor oxidoreductase (N2O-forming)|nitrous oxide reductase activity http://purl.obolibrary.org/obo/GO_0050304 GO:0050309 biolink:MolecularActivity sugar-terminal-phosphatase activity Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate. EC:3.1.3.58 go.json sugar-omega-phosphate phosphohydrolase activity|xylitol-5-phosphatase activity http://purl.obolibrary.org/obo/GO_0050309 GO:0050307 biolink:MolecularActivity sucrose-phosphate phosphatase activity Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. EC:3.1.3.24|KEGG_REACTION:R00805|KEGG_REACTION:R06211|MetaCyc:SUCROSE-PHOSPHATASE-RXN|RHEA:19289 go.json sucrose-6F-phosphate phosphohydrolase activity|sucrose-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050307 GO:0050308 biolink:MolecularActivity sugar-phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. EC:3.1.3.23|KEGG_REACTION:R00804|MetaCyc:SUGAR-PHOSPHATASE-RXN go.json sugar-phosphate phosphatase activity|sugar-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050308 GO:0050312 biolink:MolecularActivity sulfoacetaldehyde lyase activity Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite. EC:4.4.1.- go.json sulphoacetaldehyde lyase activity http://purl.obolibrary.org/obo/GO_0050312 GO:0050313 biolink:MolecularActivity sulfur dioxygenase activity Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+. EC:1.13.11.18|MetaCyc:RXN-13161|RHEA:12981|Reactome:R-HSA-1614605 go.json S-sulfanylglutathione:oxygen oxidoreductase activity|sulfur oxygenase activity|sulfur:oxygen oxidoreductase activity|sulphur dioxygenase activity http://purl.obolibrary.org/obo/GO_0050313 GO:0050310 biolink:MolecularActivity sulfite dehydrogenase activity Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c. EC:1.8.2.1|MetaCyc:SULFITE-DEHYDROGENASE-RXN|RHEA:14281 go.json sulfite cytochrome c reductase activity|sulfite-cytochrome c oxidoreductase activity|sulfite:ferricytochrome-c oxidoreductase activity|sulphite dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050310 GO:0050311 biolink:MolecularActivity sulfite reductase (ferredoxin) activity Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin. EC:1.8.7.1|MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN|RHEA:23132 go.json ferredoxin-sulfite reductase activity|hydrogen-sulfide:ferredoxin oxidoreductase activity|sulphite reductase (ferredoxin) activity http://purl.obolibrary.org/obo/GO_0050311 GO:0050316 biolink:MolecularActivity T2-induced deoxynucleotide kinase activity Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP. EC:2.7.4.12|MetaCyc:GMKALT-RXN|RHEA:12697 go.json ATP:(d)NMP phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050316 GO:0050317 biolink:MolecularActivity tagatose kinase activity Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+. EC:2.7.1.101|KEGG_REACTION:R02927|MetaCyc:TAGATOSE-KINASE-RXN|RHEA:15513 go.json ATP:D-tagatose 6-phosphotransferase activity|D-tagatose 6-phosphate kinase activity|tagatose 6-phosphate kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050317 GO:0050314 biolink:MolecularActivity sym-norspermidine synthase activity Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+. EC:2.5.1.23|KEGG_REACTION:R03271|MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN|RHEA:23244 go.json S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity http://purl.obolibrary.org/obo/GO_0050314 GO:0050315 biolink:MolecularActivity synephrine dehydratase activity Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium. EC:4.2.1.88|KEGG_REACTION:R03359|MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN|RHEA:32203 go.json 1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming) http://purl.obolibrary.org/obo/GO_0050315 GO:0050318 biolink:MolecularActivity tannase activity Catalysis of the reaction: digallate + H2O = 2 gallate + H+. EC:3.1.1.20|KEGG_REACTION:R00053|MetaCyc:TANNASE-RXN|RHEA:16365 go.json tannase S|tannin acetylhydrolase activity|tannin acylhydrolase activity http://purl.obolibrary.org/obo/GO_0050318 GO:0050319 biolink:MolecularActivity tartrate decarboxylase activity Catalysis of the reaction: L-tartrate + H+ = D-glycerate + CO2. EC:4.1.1.73|KEGG_REACTION:R01751|MetaCyc:TARTRATE-DECARBOXYLASE-RXN|RHEA:13317 go.json (R,R)-tartrate carboxy-lyase (D-glycerate-forming)|(R,R)-tartrate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0050319 GO:0050323 biolink:MolecularActivity taurine dehydrogenase activity Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde. EC:1.4.99.2|KEGG_REACTION:R07167|MetaCyc:TAURINE-DEHYDROGENASE-RXN|RHEA:18709 go.json taurine:(acceptor) oxidoreductase (deaminating)|taurine:acceptor oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0050323 GO:0050324 biolink:MolecularActivity taurocyamine kinase activity Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H+. EC:2.7.3.4|KEGG_REACTION:R03785|MetaCyc:TAUROCYAMINE-KINASE-RXN|RHEA:22516 go.json ATP:taurocyamine N-phosphotransferase activity|ATP:taurocyamine phosphotransferase activity|taurocyamine phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050324 GO:0050321 biolink:MolecularActivity tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. EC:2.7.11.26|MetaCyc:TAU-PROTEIN-KINASE-RXN go.json ATP:tau-protein O-phosphotransferase activity|CDK5/p23|GSK|STK31|TPK|TPK I|TPK II|TTK|[Tau protein] kinase activity|brain protein kinase PK40erk activity|cdk5/p20|glycogen synthase kinase-3beta activity|protein tau kinase activity|tau kinase activity|tau protein kinase activity|tau-protein kinase I activity|tau-protein kinase II activity|tau-tubulin kinase activity http://purl.obolibrary.org/obo/GO_0050321 GO:0050322 biolink:MolecularActivity taurine-2-oxoglutarate transaminase activity Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate. EC:2.6.1.55|MetaCyc:RXN-2301|RHEA:16353 go.json taurine aminotransferase activity|taurine transaminase activity|taurine--alpha-ketoglutarate aminotransferase activity|taurine--glutamate transaminase activity|taurine:2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0050322 GO:0050327 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050327 GO:0050328 biolink:MolecularActivity tetrahydroberberine oxidase activity Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2. EC:1.3.3.8|MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN|RHEA:13489 go.json (S)-THB oxidase activity|(S)-tetrahydroberberine:oxygen oxidoreductase activity|THB oxidase activity http://purl.obolibrary.org/obo/GO_0050328 GO:0050325 biolink:MolecularActivity tauropine dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine. EC:1.5.1.23|KEGG_REACTION:R01683|MetaCyc:TAUROPINE-DEHYDROGENASE-RXN|RHEA:12580 go.json 2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)|N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming) http://purl.obolibrary.org/obo/GO_0050325 GO:0050326 biolink:MolecularActivity taxifolin 8-monooxygenase activity Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O. EC:1.14.13.19|MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN go.json taxifolin hydroxylase activity|taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating) http://purl.obolibrary.org/obo/GO_0050326 GO:0050329 biolink:MolecularActivity tetrahydroxypteridine cycloisomerase activity Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate. EC:5.5.1.3|KEGG_REACTION:R04154|MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN|RHEA:18097 go.json tetrahydroxypteridine lyase (isomerizing) http://purl.obolibrary.org/obo/GO_0050329 GO:0015997 biolink:MolecularActivity obsolete ubiquinone biosynthetic process monooxygenase activity OBSOLETE. (Was not defined before being made obsolete). go.json coenzyme Q biosynthesis monooxygenase activity|coenzyme Q biosynthetic process monooxygenase activity|ubiquinone anabolism monooxygenase activity|ubiquinone biosynthetic process monooxygenase activity|ubiquinone formation monooxygenase activity|ubiquinone synthesis monooxygenase activity True http://purl.obolibrary.org/obo/GO_0015997 GO:0015998 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015998 GO:0015999 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015999 GO:0015993 biolink:BiologicalProcess obsolete molecular hydrogen transport OBSOLETE. The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json True http://purl.obolibrary.org/obo/GO_0015993 GO:0015994 biolink:BiologicalProcess chlorophyll metabolic process The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. go.json chlorophyll metabolism http://purl.obolibrary.org/obo/GO_0015994 GO:0015995 biolink:BiologicalProcess chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. MetaCyc:CHLOROPHYLL-SYN go.json chlorophyll anabolism|chlorophyll biosynthesis|chlorophyll formation|chlorophyll synthesis http://purl.obolibrary.org/obo/GO_0015995 GO:0015996 biolink:BiologicalProcess chlorophyll catabolic process The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products. go.json chlorophyll breakdown|chlorophyll catabolism|chlorophyll degradation http://purl.obolibrary.org/obo/GO_0015996 GO:0015990 biolink:BiologicalProcess electron transport coupled proton transport The transport of protons against an electrochemical gradient, using energy from electron transport. go.json http://purl.obolibrary.org/obo/GO_0015990 GO:0015991 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015991 GO:0015992 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015992 GO:0050320 biolink:MolecularActivity tartrate epimerase activity Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate. EC:5.1.2.5|KEGG_REACTION:R02546|MetaCyc:TARTRATE-EPIMERASE-RXN|RHEA:22212 go.json tartaric racemase activity http://purl.obolibrary.org/obo/GO_0050320 GO:0050334 biolink:MolecularActivity thiaminase activity Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+. EC:3.5.99.2|KEGG_REACTION:R02133|MetaCyc:THIAMINASE-RXN|RHEA:17509 go.json thiaminase II activity http://purl.obolibrary.org/obo/GO_0050334 GO:0050335 biolink:MolecularActivity thiocyanate isomerase activity Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate. EC:5.99.1.1|KEGG_REACTION:R04010|MetaCyc:THIOCYANATE-ISOMERASE-RXN|RHEA:10004 go.json benzyl-thiocyanate isomerase activity|isothiocyanate isomerase activity http://purl.obolibrary.org/obo/GO_0050335 GO:0050332 biolink:MolecularActivity thiamine pyridinylase activity Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine. EC:2.5.1.2|KEGG_REACTION:R02863|MetaCyc:THIAMIN-PYRIDINYLASE-RXN|RHEA:17697 go.json pyrimidine transferase activity|thiamin hydrolase activity|thiamin pyridinolase activity|thiamin pyridinylase activity|thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity|thiaminase I activity|thiamine hydrolase activity|thiamine pyridinolase activity|thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity http://purl.obolibrary.org/obo/GO_0050332 GO:0050333 biolink:MolecularActivity thiamine triphosphate phosphatase activity Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate. EC:3.6.1.28|KEGG_REACTION:R00618|MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN|RHEA:11744|Reactome:R-HSA-965067 go.json ThTPase activity|thiamin-triphosphatase activity|thiamine triphosphatase activity|thiamine-triphosphatase activity|thiamine-triphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050333 GO:0050338 biolink:MolecularActivity thiosulfate dehydrogenase activity Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c. EC:1.8.2.2|MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN|RHEA:20549 go.json tetrathionate synthase activity|thiosulfate oxidase activity|thiosulfate-acceptor oxidoreductase activity|thiosulfate-oxidizing enzyme|thiosulfate:ferricytochrome-c oxidoreductase activity|thiosulphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050338 GO:0050339 biolink:MolecularActivity TTPase activity Catalysis of the reaction: dTTP + H2O = dTDP + H+ + phosphate. EC:3.6.1.39|MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN|RHEA:19013 go.json dTTP nucleotidohydrolase activity|dTTPase activity|deoxythymidine-5'-triphosphatase activity|thymidine triphosphatase activity|thymidine triphosphate nucleotidohydrolase activity|thymidine-triphosphatase activity http://purl.obolibrary.org/obo/GO_0050339 GO:0050336 biolink:MolecularActivity thioethanolamine S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA. EC:2.3.1.11|KEGG_REACTION:R03668|MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN|RHEA:23280 go.json acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity|acetyl-CoA:thioethanolamine S-acetyltransferase activity|thioethanolamine acetyltransferase activity|thioltransacetylase B activity http://purl.obolibrary.org/obo/GO_0050336 GO:0050337 biolink:MolecularActivity thiosulfate-thiol sulfurtransferase activity Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide. EC:2.8.1.3|MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN|RHEA:14505|Reactome:R-HSA-1655879 go.json glutathione-dependent thiosulfate reductase activity|sulfane reductase activity|sulfane sulfurtransferase activity|thiosulfate:thiol sulfurtransferase activity|thiosulphate-thiol sulphurtransferase activity http://purl.obolibrary.org/obo/GO_0050337 GO:0050330 biolink:MolecularActivity theanine hydrolase activity Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine. EC:3.5.1.65|KEGG_REACTION:R02930|MetaCyc:THEANINE-HYDROLASE-RXN|RHEA:18013 go.json 5-N-ethyl-L-glutamine amidohydrolase activity|L-theanine amidohydrolase activity|N5-ethyl-L-glutamine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050330 GO:0050331 biolink:MolecularActivity thiamine-diphosphate kinase activity Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate. EC:2.7.4.15|MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN|RHEA:11240|Reactome:R-HSA-997381 go.json ATP:thiamin-diphosphate phosphotransferase activity|ATP:thiamine-diphosphate phosphotransferase activity|TDP kinase activity|protein bound thiamin diphosphate:ATP phosphoryltransferase activity|thiamin diphosphate kinase activity|thiamin diphosphate phosphotransferase activity|thiamin pyrophosphate kinase activity|thiamin-diphosphate kinase activity|thiamine diphosphate kinase activity http://purl.obolibrary.org/obo/GO_0050331 GO:0050345 biolink:MolecularActivity trans-epoxysuccinate hydrolase activity Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate. EC:3.3.2.4|KEGG_REACTION:R02547|MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN|RHEA:20740 go.json tartrate epoxydase activity|trans-2,3-epoxysuccinate hydrolase activity|trans-epoxysuccinate hydratase activity http://purl.obolibrary.org/obo/GO_0050345 GO:0050346 biolink:MolecularActivity trans-L-3-hydroxyproline dehydratase activity Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+. EC:4.2.1.77|KEGG_REACTION:R04374|MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN|RHEA:10320 go.json trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)|trans-L-3-hydroxyproline hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050346 GO:0050343 biolink:MolecularActivity trans-2-enoyl-CoA reductase (NAD+) activity Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH. EC:1.3.1.44|MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN|RHEA:18177 go.json acyl-CoA:NAD+ trans-2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050343 GO:0050344 biolink:MolecularActivity trans-cinnamate 2-monooxygenase activity Catalysis of the reaction: trans-cinnamate + H+ + NADPH + O2 = 2-coumarate + H2O + NADP+. EC:1.14.13.14|KEGG_REACTION:R02254|MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN|RHEA:10956 go.json cinnamate 2-hydroxylase activity|cinnamate 2-monooxygenase activity|cinnamic 2-hydroxylase activity|cinnamic acid 2-hydroxylase activity|trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)|trans-cinnamic acid 2-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050344 GO:0050349 biolink:MolecularActivity triacetate-lactonase activity Catalysis of the reaction: H2O + triacetate lactone = triacetate. EC:3.1.1.38|KEGG_REACTION:R03702|MetaCyc:RXN-20777|RHEA:22260 go.json TAL hydrolase activity|triacetate lactone hydrolase activity|triacetic acid lactone hydrolase activity|triacetic lactone hydrolase activity|triacetolactone lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0050349 GO:0050347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050347 GO:0050348 biolink:MolecularActivity trehalose O-mycolyltransferase activity Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose. EC:2.3.1.122|KEGG_REACTION:R07248|MetaCyc:RXN1G-874|RHEA:23472 go.json alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity|alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity http://purl.obolibrary.org/obo/GO_0050348 GO:0015979 biolink:BiologicalProcess photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. Wikipedia:Photosynthesis go.json http://purl.obolibrary.org/obo/GO_0015979 goslim_chembl|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant|prokaryote_subset GO:0015975 biolink:BiologicalProcess energy derivation by oxidation of reduced inorganic compounds The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released. Wikipedia:Lithotrophy go.json chemolithotrophie|chemolithotrophy|lithotrophy http://purl.obolibrary.org/obo/GO_0015975 GO:0015976 biolink:BiologicalProcess carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. Wikipedia:Heterotroph go.json carbon utilization by utilization of organic compounds|heterotrophy http://purl.obolibrary.org/obo/GO_0015976 goslim_chembl|goslim_pir GO:0015977 biolink:BiologicalProcess carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). Wikipedia:Carbon_fixation go.json autotrophic CO2 fixation|autotrophic CO2 fixation pathway|autotrophy|carbon dioxide fixation http://purl.obolibrary.org/obo/GO_0015977 GO:0015978 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015978 GO:0015971 biolink:BiologicalProcess guanosine tetraphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. go.json guanosine tetraphosphate (5'-ppGpp-3') catabolic process|guanosine tetraphosphate (5'-ppGpp-3') catabolism|guanosine tetraphosphate breakdown|guanosine tetraphosphate catabolism|guanosine tetraphosphate degradation http://purl.obolibrary.org/obo/GO_0015971 GO:0015972 biolink:BiologicalProcess guanosine pentaphosphate metabolic process The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. go.json guanosine pentaphosphate (5'-pppGpp-3') metabolic process|guanosine pentaphosphate (5'-pppGpp-3') metabolism|guanosine pentaphosphate metabolism http://purl.obolibrary.org/obo/GO_0015972 GO:0015973 biolink:BiologicalProcess guanosine pentaphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. go.json guanosine pentaphosphate (5'-pppGpp-3') biosynthesis|guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process|guanosine pentaphosphate anabolism|guanosine pentaphosphate biosynthesis|guanosine pentaphosphate formation|guanosine pentaphosphate synthesis http://purl.obolibrary.org/obo/GO_0015973 GO:0015974 biolink:BiologicalProcess guanosine pentaphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. go.json guanosine pentaphosphate (5'-pppGpp-3') catabolic process|guanosine pentaphosphate (5'-pppGpp-3') catabolism|guanosine pentaphosphate breakdown|guanosine pentaphosphate catabolism|guanosine pentaphosphate degradation http://purl.obolibrary.org/obo/GO_0015974 GO:0015970 biolink:BiologicalProcess guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. go.json guanosine tetraphosphate (5'-ppGpp-3') biosynthesis|guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process|guanosine tetraphosphate anabolism|guanosine tetraphosphate biosynthesis|guanosine tetraphosphate formation|guanosine tetraphosphate synthesis http://purl.obolibrary.org/obo/GO_0015970 GO:0050341 biolink:MolecularActivity thymine dioxygenase activity Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2. EC:1.14.11.6|MetaCyc:THYMINE-DIOXYGENASE-RXN|RHEA:10316 go.json 5-hydroxy-methyluracil dioxygenase activity|5-hydroxymethyluracil oxygenase activity|thymine 7-hydroxylase activity|thymine,2-oxoglutarate dioxygenase activity|thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating) http://purl.obolibrary.org/obo/GO_0050341 GO:0050342 biolink:MolecularActivity tocopherol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol. EC:2.1.1.95|MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN|RHEA:24012 go.json S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity|gamma-tocopherol methyltransferase activity http://purl.obolibrary.org/obo/GO_0050342 GO:0050340 biolink:MolecularActivity thymidylate 5'-phosphatase activity Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate. EC:3.1.3.35|MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN|RHEA:11080 go.json dTMPase activity|deoxythymidylate 5'-nucleotidase activity|deoxythymidylate phosphohydrolase activity|deoxythymidylic 5'-nucleotidase activity|thymidylate 5' phosphatase activity|thymidylate 5'-nucleotidase activity|thymidylate 5'-phosphohydrolase activity|thymidylate nucleotidase activity http://purl.obolibrary.org/obo/GO_0050340 GO:0050356 biolink:MolecularActivity tropine dehydrogenase activity Catalysis of the reaction: NADP+ + tropine = H+ + NADPH + tropinone. EC:1.1.1.206|KEGG_REACTION:R02832|MetaCyc:TROPINE-DEHYDROGENASE-RXN|RHEA:18357 go.json tropine:NADP+ 3alpha-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050356 GO:0050357 biolink:MolecularActivity tropinesterase activity Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine. EC:3.1.1.10|KEGG_REACTION:R03563|MetaCyc:TROPINESTERASE-RXN|RHEA:23304 go.json atropinase activity|atropine acylhydrolase activity|atropine esterase activity|atropinesterase activity|tropine esterase activity http://purl.obolibrary.org/obo/GO_0050357 GO:0050354 biolink:MolecularActivity triokinase activity Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+. EC:2.7.1.28|KEGG_REACTION:R01059|MetaCyc:TRIOKINASE-RXN|RHEA:13941|Reactome:R-HSA-70349 go.json ATP:D-glyceraldehyde 3-phosphotransferase activity|D-triokinase activity|trio triose kinase (phosphorylating)|triose kinase activity http://purl.obolibrary.org/obo/GO_0050354 GO:0050355 biolink:MolecularActivity inorganic triphosphate phosphatase activity Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate. EC:3.6.1.25|KEGG_REACTION:R00138|MetaCyc:TRIPHOSPHATASE-RXN|RHEA:14157 go.json inorganic triphosphatase activity|triphosphatase activity|triphosphate phosphohydrolase activity|tripolyphosphatase activity http://purl.obolibrary.org/obo/GO_0050355 GO:0050358 biolink:MolecularActivity tropinone reductase activity Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone. EC:1.1.1.236|KEGG_REACTION:R06734|MetaCyc:TROPINONE-REDUCTASE-RXN|RHEA:24244 go.json pseudotropine forming tropinone reductase activity|pseudotropine:NADP+ 3-oxidoreductase activity|tropinone (psi-tropine-forming) reductase activity|tropinone reductase II activity http://purl.obolibrary.org/obo/GO_0050358 GO:0050359 biolink:MolecularActivity tropomyosin kinase activity Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin. EC:2.7.11.28|MetaCyc:TROPOMYOSIN-KINASE-RXN go.json ATP:tropomyosin O-phosphotransferase activity|STK|tropomyosin kinase (phosphorylating) activity http://purl.obolibrary.org/obo/GO_0050359 GO:0015986 biolink:BiologicalProcess proton motive force-driven ATP synthesis The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. go.json ATP synthesis coupled proton transport|chemiosmosis http://purl.obolibrary.org/obo/GO_0015986 GO:0015987 biolink:BiologicalProcess GTP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis. go.json http://purl.obolibrary.org/obo/GO_0015987 GO:0015988 biolink:BiologicalProcess energy coupled proton transmembrane transport, against electrochemical gradient The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport. go.json http://purl.obolibrary.org/obo/GO_0015988 GO:0015989 biolink:BiologicalProcess obsolete light-driven proton transport OBSOLETE. The transport of protons against an electrochemical gradient, using energy from light. go.json True http://purl.obolibrary.org/obo/GO_0015989 GO:0015982 biolink:BiologicalProcess obsolete antiport OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction. go.json antiport True http://purl.obolibrary.org/obo/GO_0015982 GO:0015983 biolink:BiologicalProcess obsolete symport OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction. go.json symport True http://purl.obolibrary.org/obo/GO_0015983 GO:0015984 biolink:BiologicalProcess obsolete uniport OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion. go.json uniport True http://purl.obolibrary.org/obo/GO_0015984 GO:0015985 biolink:BiologicalProcess energy coupled proton transport, down electrochemical gradient The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. go.json http://purl.obolibrary.org/obo/GO_0015985 GO:0015980 biolink:BiologicalProcess energy derivation by oxidation of organic compounds The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. go.json chemoorganotrophy http://purl.obolibrary.org/obo/GO_0015980 GO:0015981 biolink:BiologicalProcess obsolete passive proton transport, down the electrochemical gradient OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low. go.json passive proton transport, down the electrochemical gradient True http://purl.obolibrary.org/obo/GO_0015981 GO:0050352 biolink:MolecularActivity trimethylamine-oxide aldolase activity Catalysis of the reaction: H+ + trimethylamine N-oxide = dimethylamine + formaldehyde. EC:4.1.2.32|KEGG_REACTION:R02512|MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN|RHEA:20217|UM-BBD_reactionID:r1409 go.json trimethylamine N-oxide aldolase activity|trimethylamine N-oxide demethylase activity|trimethylamine N-oxide formaldehyde-lyase activity|trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)|trimethylamine-N-oxide formaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0050352 GO:0050353 biolink:MolecularActivity trimethyllysine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate. EC:1.14.11.8|KEGG_REACTION:R03451|MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN|RHEA:14181|Reactome:R-HSA-71241 go.json 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|TML dioxygenase activity|TML hydroxylase activity|TML-alpha-ketoglutarate dioxygenase activity|TMLD activity|epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity|trimethyllysine alpha-ketoglutarate dioxygenase activity|trimethyllysine,2-oxoglutarate dioxygenase activity http://purl.obolibrary.org/obo/GO_0050353 GO:0050350 biolink:MolecularActivity trihydroxystilbene synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. EC:2.3.1.95|MetaCyc:RXN-87|RHEA:11936 go.json malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)|resveratrol synthase activity|stilbene synthase activity http://purl.obolibrary.org/obo/GO_0050350 GO:0050351 biolink:MolecularActivity trimetaphosphatase activity Catalysis of the reaction: H2O + trimetaphosphate = 2 H+ + triphosphate. EC:3.6.1.2|KEGG_REACTION:R02504|MetaCyc:TRIMETAPHOSPHATASE-RXN|RHEA:11088 go.json inorganic trimetaphosphatase activity|trimetaphosphate hydrolase activity http://purl.obolibrary.org/obo/GO_0050351 GO:0050367 biolink:MolecularActivity tyrosine-arginine ligase activity Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+. EC:6.3.2.24|KEGG_REACTION:R00735|MetaCyc:TYROSINE--ARGININE-LIGASE-RXN|RHEA:15345 go.json L-tyrosine:L-arginine ligase (AMP-forming)|kyotorphin synthase activity|kyotorphin synthetase activity|kyotorphin-synthesizing enzyme activity|tyrosyl-arginine synthase activity http://purl.obolibrary.org/obo/GO_0050367 GO:0001312 biolink:BiologicalProcess obsolete replication of extrachromosomal rDNA circles involved in replicative cell aging OBSOLETE. Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication. go.json replication of extrachromosomal rDNA circles during replicative cell ageing|replication of extrachromosomal rDNA circles during replicative cell aging|replication of extrachromosomal ribosomal DNA circles during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001312 GO:0050368 biolink:MolecularActivity tyrosine 2,3-aminomutase activity Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate. EC:5.4.3.6|KEGG_REACTION:R00739|MetaCyc:TYROSINE-23-AMINOMUTASE-RXN|RHEA:15781 go.json L-tyrosine 2,3-aminomutase activity|tyrosine alpha,beta-mutase activity http://purl.obolibrary.org/obo/GO_0050368 GO:0001313 biolink:BiologicalProcess obsolete formation of extrachromosomal circular DNA involved in replicative cell aging OBSOLETE. Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age. go.json assembly of extrachromosomal circular DNA involved in replicative cell aging|formation of extrachromosomal circular DNA during replicative cell ageing|formation of extrachromosomal circular DNA during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001313 GO:0050365 biolink:MolecularActivity tryptophanamidase activity Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4. EC:3.5.1.57|KEGG_REACTION:R00682|MetaCyc:TRYPTOPHANAMIDASE-RXN|RHEA:11012 go.json L-tryptophan aminopeptidase|L-tryptophanamide amidohydrolase activity|tryptophan aminopeptidase http://purl.obolibrary.org/obo/GO_0050365 GO:0001314 biolink:BiologicalProcess obsolete replication of extrachromosomal circular DNA involved in replicative cell aging OBSOLETE. Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. go.json replication of extrachromosomal circular DNA during replicative cell ageing|replication of extrachromosomal circular DNA during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001314 GO:0001315 biolink:BiologicalProcess obsolete age-dependent response to reactive oxygen species OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. go.json age-dependent response to AOS|age-dependent response to ROI|age-dependent response to ROS|age-dependent response to active oxygen species|age-dependent response to reactive oxidative species|age-dependent response to reactive oxygen intermediate True http://purl.obolibrary.org/obo/GO_0001315 GO:0050366 biolink:MolecularActivity tyramine N-feruloyltransferase activity Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine. EC:2.3.1.110|MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN|RHEA:19685 go.json feruloyl-CoA tyramine N-feruloyl-CoA transferase activity|feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity|feruloyltyramine synthase activity|tyramine N-feruloyl-CoA transferase activity|tyramine feruloyltransferase activity http://purl.obolibrary.org/obo/GO_0050366 GO:0001310 biolink:BiologicalProcess obsolete extrachromosomal rDNA circle accumulation involved in replicative cell aging OBSOLETE. Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. go.json extrachromosomal rDNA circle accumulation during replicative cell ageing|extrachromosomal rDNA circle accumulation during replicative cell aging|extrachromosomal ribosomal DNA circle accumulation during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001310 GO:0050369 biolink:MolecularActivity [tyrosine 3-monooxygenase] kinase activity Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]. EC:2.7.11.6|MetaCyc:2.7.11.6-RXN|RHEA:17133 go.json ATP:tyrosine-3-monoxygenase phosphotransferase activity|STK4|pheochromocytoma tyrosine hydroxylase-associated kinase activity|tyrosine 3-monooxygenase kinase (phosphorylating) activity|tyrosine 3-monooxygenase kinase activity http://purl.obolibrary.org/obo/GO_0050369 GO:0001311 biolink:BiologicalProcess obsolete formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging OBSOLETE. Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age. go.json assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging|formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing|formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging|formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001311 GO:0015957 biolink:BiologicalProcess bis(5'-nucleosidyl) oligophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. go.json bis(5'-nucleosidyl) oligophosphate anabolism|bis(5'-nucleosidyl) oligophosphate biosynthesis|bis(5'-nucleosidyl) oligophosphate formation|bis(5'-nucleosidyl) oligophosphate synthesis http://purl.obolibrary.org/obo/GO_0015957 GO:0015958 biolink:BiologicalProcess bis(5'-nucleosidyl) oligophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. go.json bis(5'-nucleosidyl) oligophosphate breakdown|bis(5'-nucleosidyl) oligophosphate catabolism|bis(5'-nucleosidyl) oligophosphate degradation http://purl.obolibrary.org/obo/GO_0015958 GO:0015959 biolink:BiologicalProcess diadenosine polyphosphate metabolic process The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. go.json diadenosine polyphosphate metabolism http://purl.obolibrary.org/obo/GO_0015959 GO:0015953 biolink:BiologicalProcess pyrimidine nucleotide interconversion The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide. go.json http://purl.obolibrary.org/obo/GO_0015953 GO:0015954 biolink:BiologicalProcess pyrimidine ribonucleotide interconversion The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide. go.json http://purl.obolibrary.org/obo/GO_0015954 GO:0015955 biolink:BiologicalProcess pyrimidine deoxyribonucleotide interconversion The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide. go.json http://purl.obolibrary.org/obo/GO_0015955 GO:0015956 biolink:BiologicalProcess bis(5'-nucleosidyl) oligophosphate metabolic process The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. go.json bis(5'-nucleosidyl) oligophosphate metabolism http://purl.obolibrary.org/obo/GO_0015956 GO:0015950 biolink:BiologicalProcess purine nucleotide interconversion The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide. go.json http://purl.obolibrary.org/obo/GO_0015950 GO:0015951 biolink:BiologicalProcess purine ribonucleotide interconversion The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide. go.json http://purl.obolibrary.org/obo/GO_0015951 GO:0015952 biolink:BiologicalProcess purine deoxyribonucleotide interconversion The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide. go.json http://purl.obolibrary.org/obo/GO_0015952 GO:0050360 biolink:MolecularActivity tryptophan 2'-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3. EC:1.13.99.3|MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN|RHEA:22620 go.json L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)|TSO I|TSO II|TSO activity|indole-3-alkane alpha-hydroxylase activity|indolyl-3-alkan alpha-hydroxylase activity|tryptophan side chain oxidase II|tryptophan side chain oxidase activity|tryptophan side chain oxidase type I|tryptophan side-chain alpha,beta-oxidase activity|tryptophan side-chain oxidase activity http://purl.obolibrary.org/obo/GO_0050360 GO:0001316 biolink:BiologicalProcess obsolete age-dependent response to reactive oxygen species involved in replicative cell aging OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. go.json age-dependent response to AOS during replicative cell aging|age-dependent response to ROI during replicative cell aging|age-dependent response to ROS during replicative cell aging|age-dependent response to active oxygen species during replicative cell aging|age-dependent response to reactive oxidative species during replicative cell aging|age-dependent response to reactive oxygen intermediate during replicative cell aging|age-dependent response to reactive oxygen species during replicative cell ageing|age-dependent response to reactive oxygen species during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001316 GO:0050363 biolink:MolecularActivity tryptophan dehydrogenase activity Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+. EC:1.4.1.19|MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN go.json L-Trp-dehydrogenase activity|L-tryptophan dehydrogenase activity|L-tryptophan:NAD(P)+ oxidoreductase (deaminating)|NAD(P)+-L-tryptophan dehydrogenase activity|TDH|TrpDH activity http://purl.obolibrary.org/obo/GO_0050363 GO:0050364 biolink:MolecularActivity tryptophan dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan. EC:2.5.1.34|MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN|RHEA:14173 go.json 4-(gamma,gamma-dimethylallyl)tryptophan synthase activity|DMAT synthetase activity|dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity|dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity|dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity|dimethylallyltryptophan synthetase activity http://purl.obolibrary.org/obo/GO_0050364 GO:0001317 biolink:BiologicalProcess obsolete accumulation of oxidatively modified proteins involved in replicative cell aging OBSOLETE. Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking. go.json accumulation of oxidatively modified proteins during replicative cell ageing|accumulation of oxidatively modified proteins during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001317 GO:0050361 biolink:MolecularActivity tryptophan 2-monooxygenase activity Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide. EC:1.13.12.3|KEGG_REACTION:R00679|MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN|RHEA:16165 go.json L-tryptophan:oxygen 2-oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0050361 GO:0001318 biolink:BiologicalProcess obsolete formation of oxidatively modified proteins involved in replicative cell aging OBSOLETE. Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking. go.json formation of oxidatively modified proteins during replicative cell ageing|formation of oxidatively modified proteins during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001318 GO:0050362 biolink:MolecularActivity L-tryptophan:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate. EC:2.6.1.27|MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN|RHEA:14093 go.json 5-hydroxytryptophan-ketoglutaric transaminase activity|L-phenylalanine-2-oxoglutarate aminotransferase activity|L-tryptophan aminotransferase activity|L-tryptophan transaminase activity|hydroxytryptophan aminotransferase activity|tryptophan aminotransferase activity|tryptophan transaminase activity http://purl.obolibrary.org/obo/GO_0050362 GO:0001319 biolink:BiologicalProcess obsolete inheritance of oxidatively modified proteins involved in replicative cell aging OBSOLETE. A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells. go.json inheritance of oxidatively modified proteins during replicative cell ageing|inheritance of oxidatively modified proteins during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001319 GO:0050378 biolink:MolecularActivity UDP-glucuronate 4-epimerase activity Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate. EC:5.1.3.6|KEGG_REACTION:R01385|MetaCyc:PWY-4861|MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN|RHEA:11404 go.json UDP glucuronic epimerase activity|UDP-D-galacturonic acid 4-epimerase activity|UDP-galacturonate 4-epimerase activity|UDPglucuronate 4-epimerase activity|uridine diphospho-D-galacturonic acid|uridine diphosphoglucuronate epimerase activity|uridine diphosphoglucuronic epimerase activity http://purl.obolibrary.org/obo/GO_0050378 GO:0001323 biolink:BiologicalProcess obsolete age-dependent general metabolic decline involved in chronological cell aging OBSOLETE. A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function. go.json age-dependent general metabolic decline during chronological cell ageing|age-dependent general metabolic decline during chronological cell aging True http://purl.obolibrary.org/obo/GO_0001323 GO:0001324 biolink:BiologicalProcess obsolete age-dependent response to oxidative stress involved in chronological cell aging OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism. go.json age-dependent response to oxidative stress during chronological cell ageing|age-dependent response to oxidative stress during chronological cell aging True http://purl.obolibrary.org/obo/GO_0001324 GO:0050379 biolink:MolecularActivity UDP-glucuronate 5'-epimerase activity Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate. KEGG_REACTION:R01387 go.json C-5-uronosyl epimerase activity|UDP-glucuronate 5' epimerase activity|UDP-glucuronic acid 5'-epimerase activity|UDP-glucuronic acid epimerase activity|UDPglucuronate 5'-epimerase activity|uridine diphosphoglucuronate 5'-epimerase activity http://purl.obolibrary.org/obo/GO_0050379 GO:0050376 biolink:MolecularActivity UDP-glucosamine 4-epimerase activity Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine. EC:5.1.3.16|MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN|RHEA:23492 go.json UDP-glucosamine epimerase activity|UDPglucosamine 4-epimerase activity http://purl.obolibrary.org/obo/GO_0050376 GO:0001325 biolink:BiologicalProcess formation of extrachromosomal circular DNA Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats. go.json assembly of extrachromosomal circular DNA http://purl.obolibrary.org/obo/GO_0001325 GO:0050377 biolink:MolecularActivity UDP-glucose 4,6-dehydratase activity Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose. EC:4.2.1.76|KEGG_REACTION:R00293|MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN|RHEA:21500 go.json UDP-D-glucose oxidoreductase activity|UDP-D-glucose-4,6-hydrolyase activity|UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)|UDP-glucose 4,6-hydro-lyase activity|UDPglucose 4,6-dehydratase activity|UDPglucose 4,6-hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050377 GO:0001326 biolink:BiologicalProcess replication of extrachromosomal circular DNA Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. go.json http://purl.obolibrary.org/obo/GO_0001326 GO:0001320 biolink:BiologicalProcess obsolete age-dependent response to reactive oxygen species involved in chronological cell aging OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. go.json age-dependent response to AOS during chronological cell aging|age-dependent response to ROI during chronological cell aging|age-dependent response to ROS during chronological cell aging|age-dependent response to active oxygen species during chronological cell aging|age-dependent response to reactive oxidative species during chronological cell aging|age-dependent response to reactive oxygen intermediate during chronological cell aging|age-dependent response to reactive oxygen species during chronological cell ageing|age-dependent response to reactive oxygen species during chronological cell aging True http://purl.obolibrary.org/obo/GO_0001320 GO:0001321 biolink:BiologicalProcess obsolete age-dependent general metabolic decline involved in replicative cell aging OBSOLETE. A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function. go.json age-dependent general metabolic decline during replicative cell ageing|age-dependent general metabolic decline involved in replicative cell aging True http://purl.obolibrary.org/obo/GO_0001321 GO:0001322 biolink:BiologicalProcess obsolete age-dependent response to oxidative stress involved in replicative cell aging OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism. go.json age-dependent response to oxidative stress during replicative cell ageing|age-dependent response to oxidative stress during replicative cell aging True http://purl.obolibrary.org/obo/GO_0001322 GO:0015968 biolink:BiologicalProcess stringent response A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation. Wikipedia:Stringent_response go.json http://purl.obolibrary.org/obo/GO_0015968 GO:0015969 biolink:BiologicalProcess guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. MetaCyc:PPGPPMET-PWY go.json guanosine tetraphosphate (5'-ppGpp-3') metabolic process|guanosine tetraphosphate (5'-ppGpp-3') metabolism|guanosine tetraphosphate metabolism http://purl.obolibrary.org/obo/GO_0015969 GO:0015964 biolink:BiologicalProcess diadenosine triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. go.json diadenosine triphosphate breakdown|diadenosine triphosphate catabolism|diadenosine triphosphate degradation http://purl.obolibrary.org/obo/GO_0015964 GO:0015965 biolink:BiologicalProcess diadenosine tetraphosphate metabolic process The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. go.json diadenosine tetraphosphate metabolism http://purl.obolibrary.org/obo/GO_0015965 GO:0015966 biolink:BiologicalProcess diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. go.json diadenosine tetraphosphate anabolism|diadenosine tetraphosphate biosynthesis|diadenosine tetraphosphate formation|diadenosine tetraphosphate synthesis http://purl.obolibrary.org/obo/GO_0015966 GO:0015967 biolink:BiologicalProcess diadenosine tetraphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. go.json diadenosine tetraphosphate breakdown|diadenosine tetraphosphate catabolism|diadenosine tetraphosphate degradation http://purl.obolibrary.org/obo/GO_0015967 GO:0015960 biolink:BiologicalProcess diadenosine polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. go.json diadenosine polyphosphate anabolism|diadenosine polyphosphate biosynthesis|diadenosine polyphosphate formation|diadenosine polyphosphate synthesis http://purl.obolibrary.org/obo/GO_0015960 GO:0015961 biolink:BiologicalProcess diadenosine polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. go.json diadenosine polyphosphate breakdown|diadenosine polyphosphate catabolism|diadenosine polyphosphate degradation http://purl.obolibrary.org/obo/GO_0015961 GO:0015962 biolink:BiologicalProcess diadenosine triphosphate metabolic process The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. go.json diadenosine triphosphate metabolism http://purl.obolibrary.org/obo/GO_0015962 GO:0015963 biolink:BiologicalProcess diadenosine triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. go.json diadenosine triphosphate anabolism|diadenosine triphosphate biosynthesis|diadenosine triphosphate formation|diadenosine triphosphate synthesis http://purl.obolibrary.org/obo/GO_0015963 GO:0050370 biolink:MolecularActivity tyrosine N-monooxygenase activity Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O. MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN|RHEA:22464 go.json CYP79A1 activity|L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)|tyrosine N-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050370 GO:0050371 biolink:MolecularActivity tyrosine phenol-lyase activity Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate. EC:4.1.99.2|KEGG_REACTION:R00728|MetaCyc:TYROSINE-PHENOL-LYASE-RXN|RHEA:21704 go.json L-tyrosine phenol-lyase (deaminating)|L-tyrosine phenol-lyase (deaminating; pyruvate-forming)|beta-tyrosinase activity http://purl.obolibrary.org/obo/GO_0050371 GO:0050374 biolink:MolecularActivity UDP-galacturonate decarboxylase activity Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose. EC:4.1.1.67|KEGG_REACTION:R02636|MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN|RHEA:19725 go.json UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)|UDP-D-galacturonate carboxy-lyase activity|UDP-galacturonic acid decarboxylase activity|UDPGalUA carboxy lyase activity|UDPgalacturonate decarboxylase activity http://purl.obolibrary.org/obo/GO_0050374 GO:0050375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050375 GO:0050372 biolink:MolecularActivity obsolete ubiquitin-calmodulin ligase activity OBSOLETE. Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin. MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN go.json calmodulin:ubiquitin ligase (AMP-forming)|uCaM-synthetase activity|ubiquitin-calmodulin synthetase activity|ubiquityl-calmodulin synthase activity|ubiquityl-calmodulin synthetase activity True http://purl.obolibrary.org/obo/GO_0050372 GO:0050373 biolink:MolecularActivity UDP-arabinose 4-epimerase activity Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose. EC:5.1.3.5|KEGG_REACTION:R01473|MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN|RHEA:11320 go.json UDP arabinose epimerase activity|UDP-D-xylose 4-epimerase activity|UDP-D-xylose-4-epimerase activity|UDP-L-arabinose 4-epimerase activity|UDParabinose 4-epimerase activity|uridine 5'-diphosphate-D-xylose 4-epimerase activity|uridine diphosphoarabinose epimerase activity http://purl.obolibrary.org/obo/GO_0050373 GO:1990475 biolink:CellularComponent synaptic vesicle, recycling pool A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state. go.json recycling pool of synaptic vesicles http://purl.obolibrary.org/obo/GO_1990475 GO:1990476 biolink:CellularComponent synaptic vesicle, resting pool A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool. go.json reserve pool of synaptic vesicles|resting pool of synaptic vesicles http://purl.obolibrary.org/obo/GO_1990476 GO:1990477 biolink:CellularComponent MTREC complex Protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as RNA silencing (NURS) complex. go.json Mtl1-Red1 core complex|NURS complex|PAXT complex http://purl.obolibrary.org/obo/GO_1990477 GO:1990478 biolink:BiologicalProcess response to ultrasound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus. go.json http://purl.obolibrary.org/obo/GO_1990478 GO:1990471 biolink:MolecularActivity piRNA uni-strand cluster binding Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa. go.json http://purl.obolibrary.org/obo/GO_1990471 GO:1990472 biolink:MolecularActivity piRNA dual-strand cluster binding Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription. go.json http://purl.obolibrary.org/obo/GO_1990472 GO:1990473 biolink:MolecularActivity ciliary targeting signal binding Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane. go.json CTS binding http://purl.obolibrary.org/obo/GO_1990473 GO:1990474 biolink:CellularComponent synaptic vesicle, readily releasable pool A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton. go.json RRP|readily releasable pool of synaptic vesicles http://purl.obolibrary.org/obo/GO_1990474 GO:1990470 biolink:MolecularActivity piRNA cluster binding Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs). go.json http://purl.obolibrary.org/obo/GO_1990470 GO:1990479 biolink:BiologicalProcess obsolete response to lipoic acid OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus. go.json response to 5-(1,2-dithiolan-3-yl)pentanoic acid True http://purl.obolibrary.org/obo/GO_1990479 GO:1990486 biolink:BiologicalProcess anaerobic fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. go.json anaerobic fatty acid degradation http://purl.obolibrary.org/obo/GO_1990486 GO:1990487 biolink:BiologicalProcess anaerobic lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units. go.json anaerobic lignin degradation http://purl.obolibrary.org/obo/GO_1990487 GO:1990488 biolink:BiologicalProcess anaerobic cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen. go.json anaerobic cellulose degradation http://purl.obolibrary.org/obo/GO_1990488 GO:1990489 biolink:BiologicalProcess anaerobic pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen. go.json anaerobic pectin degradation http://purl.obolibrary.org/obo/GO_1990489 GO:1990482 biolink:MolecularActivity sphingolipid alpha-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC. go.json inositol phosphorylceramide glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_1990482 GO:1990483 biolink:CellularComponent Clr6 histone deacetylase complex I'' A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3. go.json http://purl.obolibrary.org/obo/GO_1990483 GO:1990484 biolink:BiologicalProcess aerobic lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen. go.json aerobic lactic acid catabolic process http://purl.obolibrary.org/obo/GO_1990484 GO:1990485 biolink:BiologicalProcess anaerobic lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen. go.json anaerobic lactic acid catabolic process http://purl.obolibrary.org/obo/GO_1990485 GO:1990480 biolink:MolecularActivity obsolete geranyl diphosphate synthase OBSOLETE. Catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene biosynthesis. go.json True http://purl.obolibrary.org/obo/GO_1990480 GO:1990481 biolink:BiologicalProcess mRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. go.json mRNA pseudouridylation http://purl.obolibrary.org/obo/GO_1990481 GO:1990497 biolink:BiologicalProcess regulation of cytoplasmic translation in response to stress Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_1990497 GO:1990498 biolink:CellularComponent mitotic spindle microtubule Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. go.json http://purl.obolibrary.org/obo/GO_1990498 GO:1990499 biolink:CellularComponent raps-insc complex Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2). go.json Rapsynoid-Inscuteable complex|partner of inscuteable-inscuteable complex http://purl.obolibrary.org/obo/GO_1990499 GO:1990493 biolink:CellularComponent obsolete cyclin H-CDK7 complex OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json cyclin H-CDK7 complex True http://purl.obolibrary.org/obo/GO_1990493 GO:1990494 biolink:BiologicalProcess obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly. go.json regulation of mitotic cytokinesis, actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1990494 GO:1990495 biolink:BiologicalProcess obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis. go.json actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1990495 GO:1990496 biolink:BiologicalProcess obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis. go.json regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1990496 GO:1990490 biolink:CellularComponent archaeal proton-transporting A-type ATPase complex A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea. go.json A-type ATPase protein complex|archaeal A-type ATPase protein complex http://purl.obolibrary.org/obo/GO_1990490 GO:1990491 biolink:BiologicalProcess methane biosynthetic process from methanol and hydrogen The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen. go.json methane biosynthesis from methanol and hydrogen|methanogenesis from methanol and hydrogen http://purl.obolibrary.org/obo/GO_1990491 GO:1990492 biolink:BiologicalProcess obsolete mitotic cell cycle checkpoint inhibiting CAR assembly OBSOLETE. A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase. go.json Mad2-dependent mitotic cell cycle checkpoint|mitotic cell cycle checkpoint inhibiting cytokinetic actomyosin ring assembly True http://purl.obolibrary.org/obo/GO_1990492 GO:1990431 biolink:BiologicalProcess priRNA 3'-end processing The process of forming the mature 3' end of a priRNA molecule. go.json priRNA 3' end processing|primal small RNA 3'-end processing http://purl.obolibrary.org/obo/GO_1990431 GO:1990432 biolink:BiologicalProcess siRNA 3'-end processing The process of forming the mature 3' end of a siRNA molecule. go.json siRNA 3' end processing|small interfering RNA 3'-end processing http://purl.obolibrary.org/obo/GO_1990432 GO:1990433 biolink:CellularComponent CSL-Notch-Mastermind transcription factor complex A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes. go.json CSL-NotchIC-MASTERMIND complex http://purl.obolibrary.org/obo/GO_1990433 GO:1990434 biolink:CellularComponent lower tip-link density An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises. go.json LTLD http://purl.obolibrary.org/obo/GO_1990434 GO:1990430 biolink:MolecularActivity extracellular matrix protein binding Binding to a protein that is part of an extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_1990430 GO:1990439 biolink:MolecularActivity MAP kinase serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate. go.json http://purl.obolibrary.org/obo/GO_1990439 GO:1990435 biolink:CellularComponent upper tip-link density An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends. go.json UTLD http://purl.obolibrary.org/obo/GO_1990435 GO:1990436 biolink:BiologicalProcess obsolete MAPK cascade involved in oxidative stress signaling pathway OBSOLETE. The series of molecular signals in which a MAP kinase cascade activated by oxidative stress relays one or more of the signals, MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Just FYI in pombe the osmotic stress and oxidative stress MAPK cascade involve many of the same proteins, but the pathways are slightly different, therefore Im req this term. go.json MAPK cascade involved in oxidative stress signaling pathway True http://purl.obolibrary.org/obo/GO_1990436 GO:1990437 biolink:BiologicalProcess snRNA 2'-O-methylation The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990437 GO:1990438 biolink:BiologicalProcess U6 2'-O-snRNA methylation The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990438 GO:1990442 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to nitrosative stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. go.json nitrosative stress-induced apoptosis|nitrosative stress-induced intrinsic apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_1990442 GO:1990443 biolink:BiologicalProcess peptidyl-threonine autophosphorylation The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein. go.json http://purl.obolibrary.org/obo/GO_1990443 gocheck_do_not_annotate GO:1990444 biolink:MolecularActivity F-box domain binding Binding to an F-box domain of a protein. go.json http://purl.obolibrary.org/obo/GO_1990444 GO:1990445 biolink:BiologicalProcess obsolete Multiciliate cell differentiation OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems. go.json Multiciliate cell differentiation True http://purl.obolibrary.org/obo/GO_1990445 GO:1990440 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. go.json ER stress-induced upregulation of transcription|activation of transcription from RNA polymerase II promoter in response to ER stress|stimulation of transcription from RNA polymerase II promoter in response to ER stress|up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|up-regulation of transcription induced by ER stress|upregulation of Pol II transcription induced by ER stress|upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1990440 GO:1990441 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. go.json ER stress-induced negative regulation of transcription from RNA polymerase II promoter|down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|negative regulation of transcription from RNA polymerase II promoter in response to ER stress|reduction of transcription from RNA polymerase II promoter under ER stress|repression of transcription from RNA polymerase II promoter under ER stress|suppression of transcription from RNA polymerase II promoter under ER stress http://purl.obolibrary.org/obo/GO_1990441 GO:1990446 biolink:MolecularActivity U1 snRNP binding Binding to a U1 small nuclear ribonucleoprotein particle. go.json http://purl.obolibrary.org/obo/GO_1990446 GO:1990447 biolink:MolecularActivity U2 snRNP binding Binding to a U2 small nuclear ribonucleoprotein particle. go.json http://purl.obolibrary.org/obo/GO_1990447 GO:1990448 biolink:MolecularActivity exon-exon junction complex binding Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. go.json EJC binding http://purl.obolibrary.org/obo/GO_1990448 GO:1990449 biolink:CellularComponent obsolete amylin receptor OBSOLETE. A G protein-coupled signalling receptor complex consisting of the calcitonin receptor and a receptor activity-modifying protein (RAMP). Amylin is produced in beta-islet cells of the pancreas. It is implicated in selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, gastric emptying, gastric acid secretion, postprandial glucagon secretion and food intake and aids weight loss. go.json AMY1 receptor|AMY2 receptor|AMY3 receptor|CALCR-RAMP1 receptor|CALCR-RAMP2 receptor|CALCR-RAMP3 receptor|amylin receptor True http://purl.obolibrary.org/obo/GO_1990449 GO:1990453 biolink:CellularComponent nucleosome disassembly/reassembly complex A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex. go.json eaf5/7/3 complex http://purl.obolibrary.org/obo/GO_1990453 GO:1990454 biolink:CellularComponent L-type voltage-gated calcium channel complex A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. go.json cardiac muscle L-type voltage-gated calcium channel complex|skeletal muscle L-type voltage-gated calcium channel complex http://purl.obolibrary.org/obo/GO_1990454 GO:1990455 biolink:CellularComponent PTEN phosphatase complex A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function. go.json phosphatase and tensin homolog|phosphatase and tensin homolog deleted on chromosome ten homodimer|phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer http://purl.obolibrary.org/obo/GO_1990455 GO:1990456 biolink:BiologicalProcess mitochondrion-endoplasmic reticulum membrane tethering The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. go.json mitochondrion-ER attachment|mitochondrion-ER membrane tethering|mitochondrion-ER tethering|mitochondrion-endoplasmic reticulum attachment|mitochondrion-endoplasmic reticulum tethering http://purl.obolibrary.org/obo/GO_1990456 GO:1990450 biolink:MolecularActivity linear polyubiquitin binding Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next. go.json M1-linked ubiquitin chain binding http://purl.obolibrary.org/obo/GO_1990450 GO:1990451 biolink:BiologicalProcess cellular stress response to acidic pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution. go.json cellular stress response to acidity http://purl.obolibrary.org/obo/GO_1990451 GO:1990452 biolink:CellularComponent Parkin-FBXW7-Cul1 ubiquitin ligase complex A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein. go.json PRKN-FBXW7-Cul1 complex|Park2-FBXW7-Cul1 complex|Parkin-FBXW7-Cul1 protein complex|Parkin-HSel-10-Cullin-1 complex|Parkin/Cul1/F-box protein complex http://purl.obolibrary.org/obo/GO_1990452 GO:1990457 biolink:CellularComponent pexophagosome A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy. go.json http://purl.obolibrary.org/obo/GO_1990457 GO:1990458 biolink:MolecularActivity lipooligosaccharide binding Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria. go.json LOS binding|endotoxin binding http://purl.obolibrary.org/obo/GO_1990458 GO:1990459 biolink:MolecularActivity transferrin receptor binding Binding to a transferrin receptor. go.json http://purl.obolibrary.org/obo/GO_1990459 GO:1990464 biolink:MolecularActivity D-2-hydroxyacid dehydrogenase (quinone) activity Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol. go.json (R)-2-hydroxy acid dehydrogenase activity|(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity|(R)-2-hydroxyacid:quinone oxidoreductase activity|D-lactate dehydrogenase (quinone) activity|D-lactate dehydrogenase activity|D-lactate:quinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_1990464 GO:1990465 biolink:MolecularActivity aldehyde oxygenase (deformylating) activity Catalysis of the reaction a long-chain aldehyde + O2 + 2 NADPH = an alkane + formate + H2O + 2 NADP+. EC:4.1.99.5|RHEA:21440 go.json http://purl.obolibrary.org/obo/GO_1990465 GO:1990466 biolink:BiologicalProcess protein autosumoylation The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. go.json protein auto-sumoylation|protein self-sumoylation http://purl.obolibrary.org/obo/GO_1990466 gocheck_do_not_annotate GO:1990467 biolink:CellularComponent NuA3a histone acetyltransferase complex A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p. go.json http://purl.obolibrary.org/obo/GO_1990467 GO:1990460 biolink:MolecularActivity leptin receptor binding Binding to a leptin receptor. go.json http://purl.obolibrary.org/obo/GO_1990460 GO:1990461 biolink:BiologicalProcess detoxification of iron ion Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion. go.json http://purl.obolibrary.org/obo/GO_1990461 GO:1990462 biolink:CellularComponent omegasome Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites. go.json http://purl.obolibrary.org/obo/GO_1990462 GO:1990463 biolink:CellularComponent lateral cortical node A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins. go.json Skb1-containing cortical node http://purl.obolibrary.org/obo/GO_1990463 GO:1990468 biolink:CellularComponent NuA3b histone acetyltransferase complex A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p. go.json http://purl.obolibrary.org/obo/GO_1990468 GO:1990469 biolink:CellularComponent Rhino-Deadlock-Cutoff Complex Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation. go.json RDC complex|rhi-del-cuff complex http://purl.obolibrary.org/obo/GO_1990469 GO:1990871 biolink:CellularComponent Vma12-Vma22 assembly complex A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p. go.json http://purl.obolibrary.org/obo/GO_1990871 GO:1990872 biolink:BiologicalProcess obsolete negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that decreases the frequency, rate or extent of sterol import, by down regulation of transcription from an RNA polymerase II promoter. go.json negative regulation of sterol import by activation of transcription from RNA polymerase II promoter|negative regulation of sterol import by negative regulation of transcription from Pol II promoter|negative regulation of sterol import by stimulation of transcription from RNA polymerase II promoter|negative regulation of sterol import by up regulation of transcription from RNA polymerase II promoter|negative regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter|negative regulation of sterol import by upregulation of transcription from RNA polymerase II promoter|negative regulation of sterol influx by activation of transcription from RNA polymerase II promoter|negative regulation of sterol influx by negative regulation of transcription from RNA polymerase II promoter|negative regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter|negative regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter|negative regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter|negative regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter|negative regulation of sterol uptake by activation of transcription from RNA polymerase II promoter|negative regulation of sterol uptake by negative regulation of transcription from RNA polymerase II promoter|negative regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter|negative regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter|negative regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter|negative regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1990872 GO:1990873 biolink:CellularComponent obsolete intrinsic component of plasma membrane of cell tip OBSOLETE. The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip. go.json True http://purl.obolibrary.org/obo/GO_1990873 GO:1990874 biolink:BiologicalProcess vascular associated smooth muscle cell proliferation The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. go.json VSMC proliferation|vascular smooth muscle cell proliferation http://purl.obolibrary.org/obo/GO_1990874 GO:1990870 biolink:CellularComponent obsolete protein fibril OBSOLETE. A polymer of proteins that form a fine fiber. go.json True http://purl.obolibrary.org/obo/GO_1990870 GO:1990879 biolink:CellularComponent CST complex A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. go.json CTC1-OBFC1-TEN1 complex|Cdc13-Stn1-Ten1 complex http://purl.obolibrary.org/obo/GO_1990879 GO:1990875 biolink:CellularComponent nucleoplasmic side of nuclear pore The side of the nuclear pore complex (NPC) that faces the nucleoplasm. go.json nucleoplasmic side of NPC|nucleoplasmic side of nuclear pore complex|nucleoplasmic side of nucleopore http://purl.obolibrary.org/obo/GO_1990875 GO:1990876 biolink:CellularComponent cytoplasmic side of nuclear pore The side of the nuclear pore complex (NPC) that faces the cytoplasm. go.json cytoplasmic side of NPC|cytoplasmic side of nuclear pore complex|cytoplasmic side of nucleopore http://purl.obolibrary.org/obo/GO_1990876 GO:1990877 biolink:CellularComponent FNIP-folliculin RagC/D GAP A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2. go.json BFC complex|FLCN-FNIP1 complex|FLCN-FNIP2 complex|FNIP-Folliculin RagC/D GAP complex|Lst4-Lst7 complex http://purl.obolibrary.org/obo/GO_1990877 GO:1990878 biolink:BiologicalProcess cellular response to gastrin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. go.json http://purl.obolibrary.org/obo/GO_1990878 GO:1990882 biolink:BiologicalProcess rRNA acetylation The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json http://purl.obolibrary.org/obo/GO_1990882 GO:1990883 biolink:MolecularActivity rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA. go.json http://purl.obolibrary.org/obo/GO_1990883 GO:1990884 biolink:BiologicalProcess RNA acetylation The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990884 GO:1990885 biolink:MolecularActivity obsolete protein serine/threonine kinase binding OBSOLETE. Binding to a protein serine/threonine kinase. go.json True http://purl.obolibrary.org/obo/GO_1990885 GO:1990880 biolink:BiologicalProcess cellular detoxification of copper ion Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. go.json http://purl.obolibrary.org/obo/GO_1990880 GO:1990881 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage. go.json down regulation of transcription from RNA polymerase II promoter in response to DNA damage|down-regulation of transcription from RNA polymerase II promoter in response to DNA damage|downregulation of transcription from RNA polymerase II promoter in response to DNA damage|inhibition of transcription from RNA polymerase II promoter in response to DNA damage True http://purl.obolibrary.org/obo/GO_1990881 GO:1990886 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990886 GO:1990887 biolink:MolecularActivity 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+. go.json http://purl.obolibrary.org/obo/GO_1990887 GO:1990888 biolink:MolecularActivity 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+. go.json http://purl.obolibrary.org/obo/GO_1990888 GO:1990889 biolink:MolecularActivity H4K20me3 modified histone binding Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation. go.json http://purl.obolibrary.org/obo/GO_1990889 GO:1990893 biolink:BiologicalProcess mitotic chromosome centromere condensation The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis. go.json mitotic chromosome condensation at kinetochore http://purl.obolibrary.org/obo/GO_1990893 GO:1990894 biolink:BiologicalProcess obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion. go.json True http://purl.obolibrary.org/obo/GO_1990894 GO:1990895 biolink:BiologicalProcess regulation of protein localization to cell cortex of cell tip Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip. go.json http://purl.obolibrary.org/obo/GO_1990895 GO:1990896 biolink:BiologicalProcess protein localization to cell cortex of cell tip A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip. go.json http://purl.obolibrary.org/obo/GO_1990896 GO:1990890 biolink:MolecularActivity netrin receptor binding Binding to a netrin receptor. go.json http://purl.obolibrary.org/obo/GO_1990890 GO:1990891 biolink:BiologicalProcess mitotic sister chromatid arm separation The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis. go.json http://purl.obolibrary.org/obo/GO_1990891 GO:1990892 biolink:BiologicalProcess mitotic chromosome arm condensation The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells. go.json http://purl.obolibrary.org/obo/GO_1990892 GO:1990897 biolink:CellularComponent obsolete CTDK-1 complex OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13. go.json True http://purl.obolibrary.org/obo/GO_1990897 GO:1990898 biolink:BiologicalProcess obsolete meiotic DNA double-strand break clipping OBSOLETE. The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP). go.json True http://purl.obolibrary.org/obo/GO_1990898 GO:1990899 biolink:BiologicalProcess obsolete meiotic DNA double-strand break resectioning OBSOLETE. The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends. go.json True http://purl.obolibrary.org/obo/GO_1990899 GO:1990830 biolink:BiologicalProcess cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. go.json cellular response to CDF|cellular response to cholinergic differentiation factor http://purl.obolibrary.org/obo/GO_1990830 GO:1990839 biolink:BiologicalProcess response to endothelin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). go.json http://purl.obolibrary.org/obo/GO_1990839 GO:1990835 biolink:BiologicalProcess obsolete insulin-like growth factor production OBSOLETE. The appearance of an insulin-like growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IGF production True http://purl.obolibrary.org/obo/GO_1990835 GO:1990836 biolink:CellularComponent lysosomal matrix A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome. go.json http://purl.obolibrary.org/obo/GO_1990836 GO:1990837 biolink:MolecularActivity sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. go.json sequence-specific dsDNA binding http://purl.obolibrary.org/obo/GO_1990837 GO:1990838 biolink:MolecularActivity poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P). go.json http://purl.obolibrary.org/obo/GO_1990838 GO:1990831 biolink:BiologicalProcess cellular response to carcinoembryonic antigen Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins. go.json cellular response to pregnancy specific glycoprotein http://purl.obolibrary.org/obo/GO_1990831 GO:1990832 biolink:BiologicalProcess slow axonal transport The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition. go.json http://purl.obolibrary.org/obo/GO_1990832 GO:1990833 biolink:MolecularActivity clathrin-uncoating ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP. go.json http://purl.obolibrary.org/obo/GO_1990833 GO:1990834 biolink:BiologicalProcess response to odorant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. go.json http://purl.obolibrary.org/obo/GO_1990834 GO:1990840 biolink:BiologicalProcess response to lectin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. go.json http://purl.obolibrary.org/obo/GO_1990840 GO:1990841 biolink:MolecularActivity promoter-specific chromatin binding Binding to a section of chromatin that is associated with gene promoter sequences of DNA. go.json http://purl.obolibrary.org/obo/GO_1990841 GO:1990846 biolink:MolecularActivity ribonucleoside-diphosphate reductase inhibitor activity Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase. go.json http://purl.obolibrary.org/obo/GO_1990846 GO:1990847 biolink:BiologicalProcess obsolete peptide pheromone transmembrane export involved in positive regulation of conjugation with cellular fusion OBSOLETE. The directed movement of a peptide pheromone across a membrane and out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types. go.json True http://purl.obolibrary.org/obo/GO_1990847 GO:1990848 biolink:BiologicalProcess obsolete Positive regulation of removal of reactive oxygen species OBSOLETE. Any process that increases the frequency, rate or extent of removal of reactive oxygen species in a cell. go.json True http://purl.obolibrary.org/obo/GO_1990848 GO:1990849 biolink:BiologicalProcess vacuolar localization Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. go.json maintenance of vacuolar localization|maintenance of vacuolar location|maintenance of vacuole localization|maintenance of vacuole location http://purl.obolibrary.org/obo/GO_1990849 GO:1990842 biolink:BiologicalProcess obsolete response to prenatal stress OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis in the embryo or fetus during pregnancy. go.json response to PNS True http://purl.obolibrary.org/obo/GO_1990842 GO:1990843 biolink:CellularComponent obsolete subsarcolemmal mitochondrion OBSOLETE. A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers. go.json SS mitochondrion|SSM True http://purl.obolibrary.org/obo/GO_1990843 GO:1990844 biolink:CellularComponent obsolete interfibrillar mitochondrion OBSOLETE. A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers. go.json IFM|IMF mitochondrion|intermyofibrillar mitochondrion True http://purl.obolibrary.org/obo/GO_1990844 GO:1990845 biolink:BiologicalProcess adaptive thermogenesis The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. go.json http://purl.obolibrary.org/obo/GO_1990845 GO:1990850 biolink:CellularComponent H-gal-GP complex A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus. go.json Haemonchus galactose-containing glycoprotein complex|galactose-containing glycoprotein complex http://purl.obolibrary.org/obo/GO_1990850 GO:1990851 biolink:CellularComponent Wnt-Frizzled-LRP5/6 complex A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. go.json Frizzled-LRP5/6 complex|Fz/Wnt/LRP6 complex|WNT-FZD-LRP5 complex|WNT-FZD-LRP6 complex|Wnt receptor complex|Wnt-FZD-LRP5/6 trimeric complex|Wnt-induced Frizzled-LRP5/6 complex|Wnt.Fz.LRP ternary complex http://purl.obolibrary.org/obo/GO_1990851 GO:1990852 biolink:BiologicalProcess protein transport along microtubule to spindle pole body The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_1990852 GO:1990857 biolink:CellularComponent obsolete APC-Fzr1/Mfr1 complex OBSOLETE. An anaphase promoting complex bound to an activator in the Fzr1 (human)/Mfr1 (pombe) family. go.json True http://purl.obolibrary.org/obo/GO_1990857 GO:1990858 biolink:BiologicalProcess cellular response to lectin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. go.json http://purl.obolibrary.org/obo/GO_1990858 GO:1990859 biolink:BiologicalProcess cellular response to endothelin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). go.json http://purl.obolibrary.org/obo/GO_1990859 GO:1990853 biolink:BiologicalProcess obsolete histone H2A SQE motif phosphorylation OBSOLETE. The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone. go.json True http://purl.obolibrary.org/obo/GO_1990853 GO:1990854 biolink:BiologicalProcess vacuole-ER tethering The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles. go.json vacuole-ER attachment|vacuole-endoplasmic reticulum attachment|vacuole-endoplasmic reticulum tethering http://purl.obolibrary.org/obo/GO_1990854 GO:1990855 biolink:BiologicalProcess obsolete myo-inositol import across plasma membrane OBSOLETE. The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell across the plasma membrane. go.json True http://purl.obolibrary.org/obo/GO_1990855 GO:1990856 biolink:MolecularActivity methionyl-initiator methionine tRNA binding Binding to methionine-initator methionine tRNA. go.json http://purl.obolibrary.org/obo/GO_1990856 GO:1990860 biolink:CellularComponent Pho85-Pho80 CDK-cyclin complex A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin. go.json http://purl.obolibrary.org/obo/GO_1990860 GO:1990861 biolink:CellularComponent Ubp3-Bre5 deubiquitination complex A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p. go.json Ubp3-Bre5 ubiquitin protease complex http://purl.obolibrary.org/obo/GO_1990861 GO:1990862 biolink:CellularComponent nuclear membrane complex Bqt3-Bqt4 A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4. go.json http://purl.obolibrary.org/obo/GO_1990862 GO:1990863 biolink:BiologicalProcess acinar cell proliferation The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). go.json acinic cell proliferation|acinous cell proliferation http://purl.obolibrary.org/obo/GO_1990863 GO:1990868 biolink:BiologicalProcess response to chemokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. go.json http://purl.obolibrary.org/obo/GO_1990868 GO:1990869 biolink:BiologicalProcess cellular response to chemokine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. go.json http://purl.obolibrary.org/obo/GO_1990869 GO:1990864 biolink:BiologicalProcess response to growth hormone-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins. go.json response to GHRF|response to GRF|response to growth hormone-releasing factor|response to sermorelin|response to somatocrinin|response to somatoliberin|response to somatorelin http://purl.obolibrary.org/obo/GO_1990864 GO:1990865 biolink:BiologicalProcess obsolete response to intermittent hypoxia OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension. go.json True http://purl.obolibrary.org/obo/GO_1990865 GO:1990866 biolink:BiologicalProcess obsolete response to sustained hypoxia OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension. go.json True http://purl.obolibrary.org/obo/GO_1990866 GO:1990867 biolink:BiologicalProcess response to gastrin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. go.json http://purl.obolibrary.org/obo/GO_1990867 GO:0001532 biolink:MolecularActivity interleukin-21 receptor activity Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-21 receptor activity|IL-21R http://purl.obolibrary.org/obo/GO_0001532 GO:0001533 biolink:CellularComponent cornified envelope A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). go.json http://purl.obolibrary.org/obo/GO_0001533 GO:0001534 biolink:CellularComponent radial spoke Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules. Wikipedia:Radial_spoke go.json http://purl.obolibrary.org/obo/GO_0001534 goslim_pir GO:0001535 biolink:CellularComponent radial spoke head Protein complex forming portion of the radial spoke that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary or flagellum axoneme. go.json radial spokehead http://purl.obolibrary.org/obo/GO_0001535 GO:0001530 biolink:MolecularActivity lipopolysaccharide binding Binding to a lipopolysaccharide. go.json LPS binding|endotoxin binding http://purl.obolibrary.org/obo/GO_0001530 GO:0001531 biolink:MolecularActivity interleukin-21 receptor binding Binding to an interleukin-21 receptor. go.json IL-21|interleukin-21 receptor ligand http://purl.obolibrary.org/obo/GO_0001531 GO:1902258 biolink:BiologicalProcess positive regulation of apoptotic process involved in outflow tract morphogenesis Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. go.json activation of apoptosis involved in outflow tract morphogenesis|activation of apoptotic process involved in outflow tract morphogenesis|positive regulation of apoptosis involved in outflow tract morphogenesis|up regulation of apoptosis involved in outflow tract morphogenesis|up regulation of apoptotic process involved in outflow tract morphogenesis|up-regulation of apoptosis involved in outflow tract morphogenesis|up-regulation of apoptotic process involved in outflow tract morphogenesis|upregulation of apoptosis involved in outflow tract morphogenesis|upregulation of apoptotic process involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_1902258 GO:1902259 biolink:BiologicalProcess regulation of delayed rectifier potassium channel activity Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. go.json http://purl.obolibrary.org/obo/GO_1902259 gocheck_do_not_annotate GO:1902256 biolink:BiologicalProcess regulation of apoptotic process involved in outflow tract morphogenesis Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. go.json regulation of apoptosis involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_1902256 GO:1902257 biolink:BiologicalProcess negative regulation of apoptotic process involved in outflow tract morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. go.json down regulation of apoptosis involved in outflow tract morphogenesis|down regulation of apoptotic process involved in outflow tract morphogenesis|down-regulation of apoptosis involved in outflow tract morphogenesis|down-regulation of apoptotic process involved in outflow tract morphogenesis|downregulation of apoptosis involved in outflow tract morphogenesis|downregulation of apoptotic process involved in outflow tract morphogenesis|inhibition of apoptosis involved in outflow tract morphogenesis|inhibition of apoptotic process involved in outflow tract morphogenesis|negative regulation of apoptosis involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_1902257 GO:1902254 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. go.json down regulation of intrinsic apoptotic signaling pathway by p53 class mediator|down regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|down regulation of signal transduction by p53 class mediator resulting in induction of apoptosis|down-regulation of intrinsic apoptotic signaling pathway by p53 class mediator|down-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|down-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis|downregulation of intrinsic apoptotic signaling pathway by p53 class mediator|downregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|downregulation of signal transduction by p53 class mediator resulting in induction of apoptosis|inhibition of intrinsic apoptotic signaling pathway by p53 class mediator|inhibition of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|inhibition of signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|negative regulation of signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902254 GO:1902255 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. go.json activation of intrinsic apoptotic signaling pathway by p53 class mediator|activation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|activation of signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|positive regulation of signal transduction by p53 class mediator resulting in induction of apoptosis|up regulation of intrinsic apoptotic signaling pathway by p53 class mediator|up regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|up regulation of signal transduction by p53 class mediator resulting in induction of apoptosis|up-regulation of intrinsic apoptotic signaling pathway by p53 class mediator|up-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|up-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis|upregulation of intrinsic apoptotic signaling pathway by p53 class mediator|upregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|upregulation of signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902255 GO:1902263 biolink:BiologicalProcess apoptotic process involved in embryonic digit morphogenesis Any apoptotic process that is involved in embryonic digit morphogenesis. go.json apoptosis involved in embryonic digit morphogenesis|apoptotic cell death involved in embryonic digit morphogenesis|apoptotic program involved in embryonic digit morphogenesis|apoptotic programmed cell death involved in embryonic digit morphogenesis|programmed cell death by apoptosis involved in embryonic digit morphogenesis|signaling (initiator) caspase activity involved in embryonic digit morphogenesis|type I programmed cell death involved in embryonic digit morphogenesis http://purl.obolibrary.org/obo/GO_1902263 GO:1902264 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902264 GO:1902261 biolink:BiologicalProcess positive regulation of delayed rectifier potassium channel activity Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity. go.json activation of delayed rectifier potassium channel activity|up regulation of delayed rectifier potassium channel activity|up-regulation of delayed rectifier potassium channel activity|upregulation of delayed rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_1902261 gocheck_do_not_annotate GO:1902262 biolink:BiologicalProcess apoptotic process involved in blood vessel morphogenesis Any apoptotic process that is involved in blood vessel morphogenesis. go.json apoptosis involved in patterning of blood vessels|apoptotic cell death involved in patterning of blood vessels|apoptotic program involved in patterning of blood vessels|apoptotic programmed cell death involved in patterning of blood vessels|programmed cell death by apoptosis involved in patterning of blood vessels|signaling (initiator) caspase activity involved in patterning of blood vessels|type I programmed cell death involved in patterning of blood vessels http://purl.obolibrary.org/obo/GO_1902262 GO:1902260 biolink:BiologicalProcess negative regulation of delayed rectifier potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity. go.json down regulation of delayed rectifier potassium channel activity|down-regulation of delayed rectifier potassium channel activity|downregulation of delayed rectifier potassium channel activity|inhibition of delayed rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_1902260 gocheck_do_not_annotate GO:0001536 biolink:CellularComponent radial spoke stalk Protein complex forming the elongated portion of the radial spoke between the base which binds to the A-tubule of each microtubule outer doublet and the neck which connects to the spoke head within the ciliary or flagellum axoneme. go.json http://purl.obolibrary.org/obo/GO_0001536 GO:0001537 biolink:MolecularActivity N-acetylgalactosamine 4-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. Reactome:R-HSA-2022063|Reactome:R-HSA-3636919|Reactome:R-HSA-6786034 go.json N-acetylgalactosamine 4-O-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0001537 GO:0001538 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001538 GO:0001539 biolink:BiologicalProcess cilium or flagellum-dependent cell motility Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. go.json ciliary or bacterial-type flagellar motility|ciliary/flagellar motility http://purl.obolibrary.org/obo/GO_0001539 gocheck_do_not_manually_annotate GO:0001543 biolink:BiologicalProcess ovarian follicle rupture Disruption of theca cell layer releasing follicular fluid and/or the oocyte. go.json http://purl.obolibrary.org/obo/GO_0001543 GO:0001544 biolink:BiologicalProcess initiation of primordial ovarian follicle growth Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle). go.json http://purl.obolibrary.org/obo/GO_0001544 GO:0001545 biolink:BiologicalProcess primary ovarian follicle growth Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle). go.json http://purl.obolibrary.org/obo/GO_0001545 GO:0001546 biolink:BiologicalProcess preantral ovarian follicle growth Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation. go.json http://purl.obolibrary.org/obo/GO_0001546 GO:0001540 biolink:MolecularActivity amyloid-beta binding Binding to an amyloid-beta peptide/protein. go.json beta-amyloid binding http://purl.obolibrary.org/obo/GO_0001540 goslim_chembl GO:0001541 biolink:BiologicalProcess ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. go.json follicular phase http://purl.obolibrary.org/obo/GO_0001541 GO:0001542 biolink:BiologicalProcess ovulation from ovarian follicle The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0001542 GO:1902269 biolink:BiologicalProcess positive regulation of polyamine transmembrane transport Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport. go.json activation of polyamine transmembrane transport|up regulation of polyamine transmembrane transport|up-regulation of polyamine transmembrane transport|upregulation of polyamine transmembrane transport http://purl.obolibrary.org/obo/GO_1902269 GO:1902267 biolink:BiologicalProcess regulation of polyamine transmembrane transport Any process that modulates the frequency, rate or extent of polyamine transmembrane transport. go.json http://purl.obolibrary.org/obo/GO_1902267 GO:1902268 biolink:BiologicalProcess negative regulation of polyamine transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport. go.json down regulation of polyamine transmembrane transport|down-regulation of polyamine transmembrane transport|downregulation of polyamine transmembrane transport|inhibition of polyamine transmembrane transport http://purl.obolibrary.org/obo/GO_1902268 GO:1902265 biolink:BiologicalProcess abscisic acid homeostasis Any process involved in the maintenance of an internal steady state of abscisic acid within an organism or cell. go.json 2-cis-abscisate homeostasis|ABA homeostasis http://purl.obolibrary.org/obo/GO_1902265 GO:1902266 biolink:BiologicalProcess intracellular abscisic acid homeostasis A homeostatic process involved in the maintenance of a steady state level of abscisic acid within a cell. go.json cellular 2-cis-abscisate homeostasis|cellular ABA homeostasis http://purl.obolibrary.org/obo/GO_1902266 GO:1902274 biolink:BiologicalProcess positive regulation of (R)-carnitine transmembrane transport Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport. go.json activation of (R)-carnitine transmembrane transport|up regulation of (R)-carnitine transmembrane transport|up-regulation of (R)-carnitine transmembrane transport|upregulation of (R)-carnitine transmembrane transport http://purl.obolibrary.org/obo/GO_1902274 GO:1902275 biolink:BiologicalProcess regulation of chromatin organization Any process that modulates the frequency, rate or extent of chromatin organization. go.json regulation of chromatin assembly or disassembly|regulation of chromatin assembly/disassembly|regulation of chromatin modification|regulation of chromatin organisation|regulation of establishment or maintenance of chromatin architecture http://purl.obolibrary.org/obo/GO_1902275 GO:1902272 biolink:BiologicalProcess regulation of (R)-carnitine transmembrane transport Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport. go.json http://purl.obolibrary.org/obo/GO_1902272 GO:1902273 biolink:BiologicalProcess negative regulation of (R)-carnitine transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of (R)-carnitine transmembrane transport. go.json down regulation of (R)-carnitine transmembrane transport|down-regulation of (R)-carnitine transmembrane transport|downregulation of (R)-carnitine transmembrane transport|inhibition of (R)-carnitine transmembrane transport http://purl.obolibrary.org/obo/GO_1902273 GO:1902270 biolink:BiologicalProcess (R)-carnitine transmembrane transport The process in which (R)-carnitine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902270 GO:1990806 biolink:BiologicalProcess ligand-gated ion channel signaling pathway The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription. go.json ligand-gated ion channel signalling pathway http://purl.obolibrary.org/obo/GO_1990806 GO:1990807 biolink:MolecularActivity obsolete protein N-acetyltransferase activity OBSOLETE. Catalysis of the transfer of an acetyl group to a nitrogen atom on the amino acid of a protein. go.json True http://purl.obolibrary.org/obo/GO_1990807 GO:1902271 biolink:MolecularActivity D3 vitamins binding Binding to D3 vitamins. go.json http://purl.obolibrary.org/obo/GO_1902271 GO:1990808 biolink:MolecularActivity F-bar domain binding Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins. go.json http://purl.obolibrary.org/obo/GO_1990808 GO:1990809 biolink:BiologicalProcess endoplasmic reticulum tubular network membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane. go.json http://purl.obolibrary.org/obo/GO_1990809 GO:1990802 biolink:BiologicalProcess obsolete protein phosphorylation involved in DNA double-strand break processing OBSOLETE. Any protein phosphorylation that is required for DNA double-strand break processing. go.json protein amino acid phosphorylation involved in DNA double-strand break processing True http://purl.obolibrary.org/obo/GO_1990802 GO:1990803 biolink:BiologicalProcess obsolete protein phosphorylation involved in protein localization to spindle microtubule OBSOLETE. Any protein phosphorylation process involved in localizing a protein to the spindle microtubule. go.json protein amino acid phosphorylation involved in protein localisation in spindle microtubule|protein amino acid phosphorylation involved in protein localisation to spindle microtubule|protein amino acid phosphorylation involved in protein localization in spindle microtubule|protein amino acid phosphorylation involved in protein localization to spindle microtubule|protein phosphorylation involved in protein localisation in spindle microtubule|protein phosphorylation involved in protein localisation to spindle microtubule|protein phosphorylation involved in protein localization in spindle microtubule True http://purl.obolibrary.org/obo/GO_1990803 GO:1990804 biolink:BiologicalProcess obsolete protein phosphorylation involved in double-strand break repair via nonhomologous end joining OBSOLETE. Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining. go.json protein amino acid phosphorylation involved in NHEJ|protein amino acid phosphorylation involved in double-strand break repair via nonhomologous end joining|protein phosphorylation involved in NHEJ True http://purl.obolibrary.org/obo/GO_1990804 GO:1990805 biolink:CellularComponent central cylinder A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules. go.json http://purl.obolibrary.org/obo/GO_1990805 GO:0001547 biolink:BiologicalProcess antral ovarian follicle growth Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. go.json http://purl.obolibrary.org/obo/GO_0001547 GO:0001548 biolink:BiologicalProcess follicular fluid formation in ovarian follicle antrum The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis. go.json ovarian follicle antrum/follicular fluid biosynthesis|ovarian follicle antrum/follicular fluid formation http://purl.obolibrary.org/obo/GO_0001548 GO:0001549 biolink:BiologicalProcess cumulus cell differentiation The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell. go.json ovarian cumulus cell differentiation http://purl.obolibrary.org/obo/GO_0001549 GO:1990800 biolink:CellularComponent obsolete meiotic APC-fizzy-related complex OBSOLETE. An anaphase promoting complex bound to a fizzy-related family APC activator that regulates meiotic exit by activating the APC/C to target meiotic cyclins for destruction during meiosis. go.json True http://purl.obolibrary.org/obo/GO_1990800 GO:1990801 biolink:BiologicalProcess obsolete protein phosphorylation involved in mitotic spindle assembly OBSOLETE. Any protein phosphorylation that is involved in mitotic spindle assembly. go.json protein amino acid phosphorylation involved in mitotic spindle assembly|protein amino acid phosphorylation involved in spindle assembly involved in mitosis|protein phosphorylation involved in spindle assembly involved in mitosis True http://purl.obolibrary.org/obo/GO_1990801 GO:0001510 biolink:BiologicalProcess RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. go.json http://purl.obolibrary.org/obo/GO_0001510 GO:0001511 biolink:MolecularActivity obsolete fibrillin OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome. go.json fibrillin True http://purl.obolibrary.org/obo/GO_0001511 GO:0001512 biolink:MolecularActivity dihydronicotinamide riboside quinone reductase activity Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. EC:1.10.5.1|MetaCyc:1.10.99.2-RXN|RHEA:12364|Reactome:R-HSA-8936519 go.json N-ribosyldihydronicotinamide dehydrogenase (quinone) activity|NQO2|NQO2 activity|NRH:quinone oxidoreductase 2 activity|QR2 activity|quinone reductase 2 activity|ribosyldihydronicotinamide dehydrogenase (quinone) activity http://purl.obolibrary.org/obo/GO_0001512 GO:0001513 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001513 GO:1902278 biolink:BiologicalProcess positive regulation of pancreatic amylase secretion Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion. go.json activation of pancreatic amylase secretion|up regulation of pancreatic amylase secretion|up-regulation of pancreatic amylase secretion|upregulation of pancreatic amylase secretion http://purl.obolibrary.org/obo/GO_1902278 GO:1902279 biolink:BiologicalProcess positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway A cholecystokinin signaling pathway that results in positive regulation of pancreatic amylase secretion. go.json CCK-induced amylase release in pancreatic cell|CCK-mediated pancreatic amylase secretion|CCK-stimulated pancreatic amylase release|activation of pancreatic amylase secretion by cholecystokinin signaling pathway|cholecystokinin-mediated pancreatic amylase secretion|up regulation of pancreatic amylase secretion by cholecystokinin signaling pathway|up-regulation of pancreatic amylase secretion by cholecystokinin signaling pathway|upregulation of pancreatic amylase secretion by cholecystokinin signaling pathway http://purl.obolibrary.org/obo/GO_1902279 GO:1902276 biolink:BiologicalProcess regulation of pancreatic amylase secretion Any process that modulates the frequency, rate or extent of pancreatic amylase secretion. go.json http://purl.obolibrary.org/obo/GO_1902276 GO:1902277 biolink:BiologicalProcess negative regulation of pancreatic amylase secretion Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic amylase secretion. go.json down regulation of pancreatic amylase secretion|down-regulation of pancreatic amylase secretion|downregulation of pancreatic amylase secretion|inhibition of pancreatic amylase secretion http://purl.obolibrary.org/obo/GO_1902277 GO:1902285 biolink:BiologicalProcess semaphorin-plexin signaling pathway involved in neuron projection guidance Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. go.json semaphorin-plexin signaling pathway involved in neurite guidance|semaphorin-plexin signaling pathway involved in neuron process guidance|semaphorin-plexin signaling pathway involved in neuron protrusion guidance|semaphorin-plexin signaling pathway involved in neuronal cell projection guidance|semaphorin-plexin signalling pathway involved in neurite guidance|semaphorin-plexin signalling pathway involved in neuron process guidance|semaphorin-plexin signalling pathway involved in neuron projection guidance|semaphorin-plexin signalling pathway involved in neuron protrusion guidance|semaphorin-plexin signalling pathway involved in neuronal cell projection guidance http://purl.obolibrary.org/obo/GO_1902285 GO:1902286 biolink:BiologicalProcess semaphorin-plexin signaling pathway involved in dendrite guidance Any semaphorin-plexin signaling pathway that is involved in dendrite guidance. go.json semaphorin-plexin signaling pathway involved in dendritic guidance|semaphorin-plexin signalling pathway involved in dendrite guidance|semaphorin-plexin signalling pathway involved in dendritic guidance http://purl.obolibrary.org/obo/GO_1902286 GO:1902283 biolink:BiologicalProcess negative regulation of primary amine oxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity. go.json down regulation of amine oxidase (copper-containing) activity|down regulation of primary amine oxidase activity|down regulation of primary-amine:oxygen oxidoreductase (deaminating) activity|down-regulation of amine oxidase (copper-containing) activity|down-regulation of primary amine oxidase activity|down-regulation of primary-amine:oxygen oxidoreductase (deaminating) activity|downregulation of amine oxidase (copper-containing) activity|downregulation of primary amine oxidase activity|downregulation of primary-amine:oxygen oxidoreductase (deaminating) activity|inhibition of amine oxidase (copper-containing) activity|inhibition of primary amine oxidase activity|inhibition of primary-amine:oxygen oxidoreductase (deaminating) activity|negative regulation of amine oxidase (copper-containing) activity|negative regulation of primary-amine:oxygen oxidoreductase (deaminating) activity http://purl.obolibrary.org/obo/GO_1902283 gocheck_do_not_annotate GO:1902284 biolink:BiologicalProcess neuron projection extension involved in neuron projection guidance Any neuron projection extension that is involved in neuron projection guidance. go.json neurite extension involved in neurite guidance|neurite extension involved in neuron process guidance|neurite extension involved in neuron projection guidance|neurite extension involved in neuron protrusion guidance|neurite extension involved in neuronal cell projection guidance|neuron process extension involved in neurite guidance|neuron process extension involved in neuron process guidance|neuron process extension involved in neuron projection guidance|neuron process extension involved in neuron protrusion guidance|neuron process extension involved in neuronal cell projection guidance|neuron projection extension involved in neurite guidance|neuron projection extension involved in neuron process guidance|neuron projection extension involved in neuron protrusion guidance|neuron projection extension involved in neuronal cell projection guidance|neuron protrusion extension involved in neurite guidance|neuron protrusion extension involved in neuron process guidance|neuron protrusion extension involved in neuron projection guidance|neuron protrusion extension involved in neuron protrusion guidance|neuron protrusion extension involved in neuronal cell projection guidance|neuronal cell projection extension involved in neurite guidance|neuronal cell projection extension involved in neuron process guidance|neuronal cell projection extension involved in neuron projection guidance|neuronal cell projection extension involved in neuron protrusion guidance|neuronal cell projection extension involved in neuronal cell projection guidance http://purl.obolibrary.org/obo/GO_1902284 GO:1902281 biolink:BiologicalProcess negative regulation of RNA helicase activity Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity. go.json down regulation of ATP-dependent RNA helicase activity|down-regulation of ATP-dependent RNA helicase activity|downregulation of ATP-dependent RNA helicase activity|inhibition of ATP-dependent RNA helicase activity|negative regulation of ATP-dependent RNA helicase activity http://purl.obolibrary.org/obo/GO_1902281 gocheck_do_not_annotate GO:1990817 biolink:MolecularActivity poly(A) RNA polymerase activity Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. EC:2.7.7.19|MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN|RHEA:11332|Reactome:R-HSA-72185 go.json NTP polymerase activity|RNA adenylating enzyme|RNA adenyltransferase activity|RNA adenylyltransferase activity|poly(A) polymerase activity|polynucleotide adenylyltransferase activity http://purl.obolibrary.org/obo/GO_1990817 GO:1902282 biolink:MolecularActivity voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1902282 GO:1990818 biolink:BiologicalProcess L-arginine transmembrane export from vacuole The directed movement of L-arginine out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_1990818 GO:1990819 biolink:CellularComponent mating projection actin fusion focus A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location. go.json actin fusion focus http://purl.obolibrary.org/obo/GO_1990819 GO:1902280 biolink:BiologicalProcess regulation of RNA helicase activity Any process that modulates the frequency, rate or extent of ATP-dependent RNA helicase activity. go.json regulation of ATP-dependent RNA helicase activity http://purl.obolibrary.org/obo/GO_1902280 gocheck_do_not_annotate GO:1990813 biolink:BiologicalProcess meiotic centromeric cohesion protection in anaphase I The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation at meiotic anaphase I after cohesin is cleaved by separase along the arm regions. go.json anaphase cohesion protection|protection of centromeric cohesion during meiotic anaphase I http://purl.obolibrary.org/obo/GO_1990813 GO:0001518 biolink:CellularComponent voltage-gated sodium channel complex A sodium channel in a cell membrane whose opening is governed by the membrane potential. NIF_Subcellular:sao785001660 go.json voltage gated sodium channel complex|voltage-dependent sodium channel complex|voltage-sensitive sodium channel complex http://purl.obolibrary.org/obo/GO_0001518 GO:1990814 biolink:MolecularActivity DNA/DNA annealing activity An activity that faciliates the formation of a complementary double-stranded DNA molecule. go.json DNA reannealing activity http://purl.obolibrary.org/obo/GO_1990814 GO:0001519 biolink:BiologicalProcess peptide amidation The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions. go.json http://purl.obolibrary.org/obo/GO_0001519 GO:1990815 biolink:BiologicalProcess obsolete regulation of protein localization to cell division site after cytokinesis OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis. go.json True http://purl.obolibrary.org/obo/GO_1990815 GO:1990816 biolink:CellularComponent vacuole-mitochondrion membrane contact site A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles. go.json vCLAMP|vacuole and mitochondria patch http://purl.obolibrary.org/obo/GO_1990816 GO:0001514 biolink:BiologicalProcess selenocysteine incorporation The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine. RESID:AA0022 go.json http://purl.obolibrary.org/obo/GO_0001514 GO:0001515 biolink:MolecularActivity opioid peptide activity Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. go.json http://purl.obolibrary.org/obo/GO_0001515 goslim_chembl GO:1990810 biolink:BiologicalProcess microtubule anchoring at mitotic spindle pole body Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. go.json http://purl.obolibrary.org/obo/GO_1990810 GO:0001516 biolink:BiologicalProcess prostaglandin biosynthetic process The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. go.json prostaglandin anabolism|prostaglandin biosynthesis|prostaglandin formation|prostaglandin synthesis http://purl.obolibrary.org/obo/GO_0001516 GO:1990811 biolink:CellularComponent MWP complex A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin. go.json Msd1-Wdr8-Pkl1 complex http://purl.obolibrary.org/obo/GO_1990811 GO:0001517 biolink:MolecularActivity N-acetylglucosamine 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. Reactome:R-HSA-2046222|Reactome:R-HSA-3656269|Reactome:R-HSA-6786012 go.json N-acetylglucosamine 6-O-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0001517 goslim_chembl GO:1990812 biolink:CellularComponent growth cone filopodium A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. go.json http://purl.obolibrary.org/obo/GO_1990812 GO:0001521 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001521 GO:0001522 biolink:BiologicalProcess pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. Wikipedia:Pseudouridine|Wikipedia:Pseudouridylation go.json pseudouridylation http://purl.obolibrary.org/obo/GO_0001522 GO:0001523 biolink:BiologicalProcess retinoid metabolic process The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. go.json retinoid metabolism http://purl.obolibrary.org/obo/GO_0001523 GO:0001524 biolink:MolecularActivity obsolete globin OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins. go.json globin True http://purl.obolibrary.org/obo/GO_0001524 GO:0001520 biolink:CellularComponent outer dense fiber A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins. go.json outer dense fibre http://purl.obolibrary.org/obo/GO_0001520 GO:1902289 biolink:BiologicalProcess negative regulation of defense response to oomycetes Any process that stops, prevents or reduces the frequency, rate or extent of defense response to oomycetes. go.json down regulation of defense response to oomycetes|down-regulation of defense response to oomycetes|downregulation of defense response to oomycetes|inhibition of defense response to oomycetes http://purl.obolibrary.org/obo/GO_1902289 GO:1902287 biolink:BiologicalProcess semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance. go.json semaphorin-plexin signaling pathway involved in axon chemotaxis|semaphorin-plexin signaling pathway involved in axon growth cone guidance|semaphorin-plexin signaling pathway involved in axon pathfinding|semaphorin-plexin signalling pathway involved in axon chemotaxis|semaphorin-plexin signalling pathway involved in axon growth cone guidance|semaphorin-plexin signalling pathway involved in axon guidance|semaphorin-plexin signalling pathway involved in axon pathfinding http://purl.obolibrary.org/obo/GO_1902287 GO:1902288 biolink:BiologicalProcess regulation of defense response to oomycetes Any process that modulates the frequency, rate or extent of defense response to oomycetes. go.json http://purl.obolibrary.org/obo/GO_1902288 GO:1902296 biolink:BiologicalProcess DNA strand elongation involved in cell cycle DNA replication Any DNA strand elongation that is involved in cell cycle DNA replication. go.json DNA replication elongation involved in cell cycle DNA replication|DNA strand elongation during DNA replication involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902296 GO:1902297 biolink:BiologicalProcess cell cycle DNA replication DNA unwinding Any DNA unwinding that is involved in cell cycle DNA replication. go.json DNA unwinding during replication involved in cell cycle DNA replication|DNA unwinding factor involved in cell cycle DNA replication|DNA unwinding involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902297 GO:1902294 biolink:BiologicalProcess cell cycle DNA replication termination Any DNA replication termination that is involved in cell cycle DNA replication. go.json DNA replication termination involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902294 GO:1902295 biolink:BiologicalProcess synthesis of RNA primer involved in cell cycle DNA replication Any DNA replication, synthesis of RNA primer that is involved in cell cycle DNA replication. go.json DNA replication, synthesis of RNA primer involved in cell cycle DNA replication|replication priming involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902295 GO:1902292 biolink:BiologicalProcess cell cycle DNA replication initiation Any DNA replication initiation that is involved in cell cycle DNA replication. go.json DNA endoreduplication initiation involved in cell cycle DNA replication|DNA re-replication initiation involved in cell cycle DNA replication|DNA replication initiation involved in cell cycle DNA replication|DNA-dependent DNA replication initiation involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902292 GO:1990828 biolink:BiologicalProcess hepatocyte dedifferentiation The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. go.json http://purl.obolibrary.org/obo/GO_1990828 GO:1902293 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902293 GO:1990829 biolink:MolecularActivity C-rich single-stranded DNA binding Binding to C-rich, single-stranded DNA. go.json C-rich ssDNA binding http://purl.obolibrary.org/obo/GO_1990829 GO:1902290 biolink:BiologicalProcess positive regulation of defense response to oomycetes Any process that activates or increases the frequency, rate or extent of defense response to oomycetes. go.json activation of defense response to oomycetes|up regulation of defense response to oomycetes|up-regulation of defense response to oomycetes|upregulation of defense response to oomycetes http://purl.obolibrary.org/obo/GO_1902290 GO:1902291 biolink:BiologicalProcess cell cycle DNA replication DNA ligation Any DNA ligation that is involved in cell cycle DNA replication. go.json DNA ligation involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902291 GO:1990824 biolink:CellularComponent obsolete magnesium-dependent protein complex OBSOLETE. A protein complex that depends on magnesium in order for one or more of its components to remain a part of the complex. go.json True http://purl.obolibrary.org/obo/GO_1990824 GO:0001529 biolink:CellularComponent obsolete elastin OBSOLETE. (Was not defined before being made obsolete). go.json elastin True http://purl.obolibrary.org/obo/GO_0001529 GO:1990825 biolink:MolecularActivity sequence-specific mRNA binding Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. go.json http://purl.obolibrary.org/obo/GO_1990825 GO:1990826 biolink:CellularComponent nucleoplasmic periphery of the nuclear pore complex Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex. go.json associated with the nuclear pore http://purl.obolibrary.org/obo/GO_1990826 GO:1990827 biolink:MolecularActivity deaminase binding Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3). go.json http://purl.obolibrary.org/obo/GO_1990827 GO:1990820 biolink:BiologicalProcess response to mitotic DNA integrity checkpoint signaling A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling. go.json response to signal involved in mitotic DNA integrity checkpoint http://purl.obolibrary.org/obo/GO_1990820 GO:0001525 biolink:BiologicalProcess angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. Wikipedia:Angiogenesis go.json blood vessel formation from pre-existing blood vessels http://purl.obolibrary.org/obo/GO_0001525 GO:1990821 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990821 GO:0001526 biolink:BiologicalProcess obsolete proteoglycan sulfate transfer OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate. go.json proteoglycan sulfate transfer|proteoglycan sulphate transfer True http://purl.obolibrary.org/obo/GO_0001526 GO:1990822 biolink:BiologicalProcess basic amino acid transmembrane transport The directed movement of basic amino acids from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1990822 GO:0001527 biolink:CellularComponent microfibril Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins. go.json extended fibrils|fibrillin http://purl.obolibrary.org/obo/GO_0001527 GO:1990823 biolink:BiologicalProcess response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. go.json response to CDF|response to LIF|response to cholinergic differentiation factor http://purl.obolibrary.org/obo/GO_1990823 GO:0001528 biolink:MolecularActivity obsolete elastin OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues. go.json elastin True http://purl.obolibrary.org/obo/GO_0001528 GO:1902298 biolink:BiologicalProcess cell cycle DNA replication maintenance of fidelity Any maintenance of fidelity that is involved in cell cycle DNA replication. go.json maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication|maintenance of fidelity involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902298 GO:1902299 biolink:BiologicalProcess pre-replicative complex assembly involved in cell cycle DNA replication Any pre-replicative complex assembly that is involved in cell cycle DNA replication. go.json pre-RC assembly involved in cell cycle DNA replication|pre-replication complex assembly involved in cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902299 GO:0001501 biolink:BiologicalProcess skeletal system development The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). go.json skeletal development http://purl.obolibrary.org/obo/GO_0001501 GO:0001502 biolink:BiologicalProcess cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. go.json http://purl.obolibrary.org/obo/GO_0001502 GO:0001507 biolink:BiologicalProcess acetylcholine catabolic process in synaptic cleft The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission. go.json acetylcholine breakdown in synaptic cleft|acetylcholine degradation in synaptic cleft http://purl.obolibrary.org/obo/GO_0001507 GO:0001508 biolink:BiologicalProcess action potential A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. go.json http://purl.obolibrary.org/obo/GO_0001508 GO:0001509 biolink:MolecularActivity obsolete legumain activity OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds. go.json PRSC1 gene product (Homo sapiens)|asparaginyl endopeptidase activity|bean endopeptidase activity|citvac|hemoglobinase activity|legumain activity|phaseolin activity|proteinase B|vicilin peptidohydrolase activity True http://purl.obolibrary.org/obo/GO_0001509 GO:0001503 biolink:BiologicalProcess ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. Wikipedia:Ossification go.json bone biosynthesis|bone formation|osteogenesis http://purl.obolibrary.org/obo/GO_0001503 GO:0001504 biolink:BiologicalProcess neurotransmitter uptake The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. go.json neurotransmitter import|neurotransmitter import into glial cell|neurotransmitter import into neuron|neurotransmitter recycling http://purl.obolibrary.org/obo/GO_0001504 goslim_synapse GO:0001505 biolink:BiologicalProcess obsolete regulation of neurotransmitter levels OBSOLETE. Any process that modulates levels of neurotransmitter. go.json True http://purl.obolibrary.org/obo/GO_0001505 GO:0001506 biolink:BiologicalProcess obsolete neurotransmitter biosynthetic process and storage OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules. go.json neurotransmitter anabolism and storage|neurotransmitter biosynthetic process and storage|neurotransmitter formation and storage|neurotransmitter synthesis and storage True http://purl.obolibrary.org/obo/GO_0001506 GO:0050422 biolink:MolecularActivity strictosidine beta-glucosidase activity Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone. EC:3.2.1.105|KEGG_REACTION:R03820|MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN|RHEA:12917 go.json strictosidine b-glucosidase activity|strictosidine beta-D-glucohydrolase activity http://purl.obolibrary.org/obo/GO_0050422 GO:0050423 biolink:MolecularActivity thiamine oxidase activity Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2. EC:1.1.3.23|MetaCyc:THIAMIN-OXIDASE-RXN|RHEA:21280 go.json thiamin dehydrogenase activity|thiamin oxidase activity|thiamin:oxygen 5-oxidoreductase activity|thiamine dehydrogenase activity|thiamine:oxygen 5-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050423 GO:0050420 biolink:MolecularActivity maltose synthase activity Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate. EC:2.4.1.139|MetaCyc:MALTOSE-SYNTHASE-RXN|RHEA:22320 go.json alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating) http://purl.obolibrary.org/obo/GO_0050420 GO:0050421 biolink:MolecularActivity nitrite reductase (NO-forming) activity Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. EC:1.7.2.1|MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN|RHEA:15233 go.json NO-forming nitrite reductase (cytochrome) activity|NO-forming nitrite reductase activity|[nitrite reductase (cytochrome)]|cd-cytochrome nitrite reductase activity|cytochrome c-551:O2, NO2(+) oxidoreductase activity|cytochrome c-551:O2, NO2+ oxidoreductase activity|cytochrome cd activity|cytochrome cd1 activity|methyl viologen-nitrite reductase activity|nitric-oxide:ferricytochrome-c oxidoreductase activity|nitrite reductase (cytochrome; NO-forming) activity http://purl.obolibrary.org/obo/GO_0050421 GO:0050426 biolink:MolecularActivity obsolete peptidyl-glycinamidase activity OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide. go.json carboxamidopeptidase activity|carboxyamidase activity|peptidyl amino acid amide hydrolase activity|peptidyl carboxy-amidase activity|peptidyl carboxyamidase activity|peptidyl-glycinamidase activity True http://purl.obolibrary.org/obo/GO_0050426 GO:0050427 biolink:BiologicalProcess 3'-phosphoadenosine 5'-phosphosulfate metabolic process The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. MetaCyc:PWY-5340 go.json 3'-phosphoadenosine 5'-phosphosulfate metabolism|3'-phosphoadenosine 5'-phosphosulphate metabolic process|3'-phosphoadenosine 5'-phosphosulphate metabolism|3'-phosphoadenylyl-sulfate metabolic process|3'-phosphoadenylyl-sulfate metabolism|PAPS metabolic process|PAPS metabolism|adenosine 3'-phosphate 5'-phosphosulfate metabolic process|adenosine 3'-phosphate 5'-phosphosulfate metabolism|phosphoadenosine phosphosulfate metabolic process|phosphoadenosine phosphosulfate metabolism http://purl.obolibrary.org/obo/GO_0050427 GO:0050424 biolink:MolecularActivity obsolete alanine carboxypeptidase activity OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups. go.json N-benzoyl-L-alanine-amidohydrolase activity|alanine carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0050424 GO:0050425 biolink:MolecularActivity obsolete carboxypeptidase B activity OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid. go.json carboxypeptidase B activity|pancreatic carboxypeptidase B|peptidyl-L-lysine [L-arginine]hydrolase activity|protaminase activity|tissue carboxypeptidase B True http://purl.obolibrary.org/obo/GO_0050425 GO:0050428 biolink:BiologicalProcess 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. go.json 3'-phosphoadenosine 5'-phosphosulfate anabolism|3'-phosphoadenosine 5'-phosphosulfate biosynthesis|3'-phosphoadenosine 5'-phosphosulfate formation|3'-phosphoadenosine 5'-phosphosulfate synthesis|3'-phosphoadenosine 5'-phosphosulphate biosynthesis|3'-phosphoadenosine 5'-phosphosulphate biosynthetic process|3'-phosphoadenylyl-sulfate biosynthesis|3'-phosphoadenylyl-sulfate biosynthetic process|PAPS biosynthesis|PAPS biosynthetic process|adenosine 3'-phosphate 5'-phosphosulfate biosynthesis|adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process|phosphoadenosine phosphosulfate biosynthesis|phosphoadenosine phosphosulfate biosynthetic process http://purl.obolibrary.org/obo/GO_0050428 GO:0050429 biolink:MolecularActivity calcium-dependent phospholipase C activity Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. go.json http://purl.obolibrary.org/obo/GO_0050429 GO:0050433 biolink:BiologicalProcess regulation of catecholamine secretion Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. go.json http://purl.obolibrary.org/obo/GO_0050433 GO:0050434 biolink:BiologicalProcess positive regulation of viral transcription Any process that activates or increases the frequency, rate or extent of viral transcription. go.json activation of viral transcription|stimulation of viral transcription|up regulation of viral transcription|up-regulation of viral transcription|upregulation of viral transcription http://purl.obolibrary.org/obo/GO_0050434 GO:0050431 biolink:MolecularActivity transforming growth factor beta binding Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. go.json TGF-beta binding|TGFbeta binding|transforming growth factor beta ligand binding to type I receptor|transforming growth factor beta ligand binding to type II receptor http://purl.obolibrary.org/obo/GO_0050431 GO:0050432 biolink:BiologicalProcess catecholamine secretion The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. go.json http://purl.obolibrary.org/obo/GO_0050432 GO:0050437 biolink:MolecularActivity (-)-endo-fenchol synthase activity Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate. EC:4.2.3.10|KEGG_REACTION:R02004|MetaCyc:4.2.3.10-RXN|RHEA:20565 go.json (-)-endo-fenchol cyclase activity|geranyl pyrophosphate:(-)-endo-fenchol cyclase activity|geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming] http://purl.obolibrary.org/obo/GO_0050437 GO:0050438 biolink:MolecularActivity 2-ethylmalate synthase activity Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+. EC:2.3.3.6|KEGG_REACTION:R00998|MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN|RHEA:23040 go.json (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity|2-ethylmalate-3-hydroxybutanedioate synthase activity|acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|propylmalate synthase activity|propylmalic synthase activity http://purl.obolibrary.org/obo/GO_0050438 GO:0050435 biolink:BiologicalProcess amyloid-beta metabolic process The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). go.json amyloid-beta metabolism|beta-amyloid metabolic process|beta-amyloid metabolism http://purl.obolibrary.org/obo/GO_0050435 GO:0050436 biolink:MolecularActivity microfibril binding Binding to a microfibril, any small fibril occurring in biological material. go.json http://purl.obolibrary.org/obo/GO_0050436 GO:0050439 biolink:MolecularActivity 2-hydroxy-3-oxoadipate synthase activity Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2. EC:2.2.1.5|KEGG_REACTION:R00474|MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN|RHEA:14341 go.json 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity|2-hydroxy-3-oxoadipate synthetase activity|2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)|alpha-ketoglutaric-glyoxylic carboligase activity|oxoglutarate: glyoxylate carboligase activity|oxoglutarate:glyoxylate carboligase activity http://purl.obolibrary.org/obo/GO_0050439 GO:0050430 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050430 GO:0050444 biolink:MolecularActivity obsolete aquacobalamin reductase (NADPH) activity OBSOLETE. Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+. EC:1.16.1.5|MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN|RHEA:20752 go.json NADPH-linked aquacobalamin reductase activity|NADPH2:aquacob(III)alamin oxidoreductase activity|NADPH:aquacob(III)alamin oxidoreductase activity|aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity|aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|cob(II)alamin:NADP+ oxidoreductase activity True http://purl.obolibrary.org/obo/GO_0050444 GO:0050445 biolink:MolecularActivity asparagusate reductase activity Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH. EC:1.8.1.11|KEGG_REACTION:R03761|MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN|RHEA:14881 go.json 3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity|NADH2:asparagusate oxidoreductase activity|NADH:asparagusate oxidoreductase activity|asparagusate dehydrogenase activity|asparagusate reductase (NADH) activity|asparagusate reductase (NADH2)|asparagusic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050445 GO:0050442 biolink:MolecularActivity 3-propylmalate synthase activity Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+. EC:2.3.3.12|KEGG_REACTION:R03040|MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN|RHEA:14457 go.json 3-(n-propyl)-malate synthase activity|3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity|N-propylmalate synthase activity|beta-n-propylmalate synthase activity|pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming) http://purl.obolibrary.org/obo/GO_0050442 GO:0050443 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050443 GO:0050448 biolink:MolecularActivity beta-cyclopiazonate dehydrogenase activity Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2). EC:1.21.99.1|KEGG_REACTION:R04080|MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN|RHEA:14525 go.json b-cyclopiazonate dehydrogenase activity|beta-cyclopiazonate oxidocyclase activity|beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)|beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)|beta-cyclopiazonic oxidocyclase activity http://purl.obolibrary.org/obo/GO_0050448 GO:0050449 biolink:MolecularActivity casbene synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate. EC:4.2.3.8|KEGG_REACTION:R02064|MetaCyc:CASBENE-SYNTHASE-RXN|RHEA:14901 go.json casbene synthetase activity|geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)|geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming) http://purl.obolibrary.org/obo/GO_0050449 GO:0050446 biolink:MolecularActivity azobenzene reductase activity Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+. EC:1.7.1.6|MetaCyc:AZOBENZENE-REDUCTASE-RXN|RHEA:16269|UM-BBD_reactionID:r0808 go.json N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity|N,N-dimethyl-4-phenylazoaniline azoreductase activity|NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity|NADPH-dependent azoreductase activity|NADPH2-dependent azoreductase activity|NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity|NADPH:4-(dimethylamino)azobenzene oxidoreductase activity|NC-reductase activity|New coccine (NC)-reductase activity|azo reductase activity|azo-dye reductase activity|azoreductase activity|dibromopropylaminophenylazobenzoic azoreductase activity|dimethylaminobenzene reductase activity|methyl red azoreductase activity|new coccine (NC)-reductase|nicotinamide adenine dinucleotide (phosphate) azoreductase activity|orange I azoreductase activity|orange II azoreductase activity|p-aminoazobenzene reductase activity|p-dimethylaminoazobenzene azoreductase activity http://purl.obolibrary.org/obo/GO_0050446 GO:0050447 biolink:MolecularActivity zeatin 9-aminocarboxyethyltransferase activity Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+. EC:2.5.1.50|KEGG_REACTION:R03133|MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN|RHEA:17333 go.json 3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity|O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity|O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)|O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity|beta-(9-cytokinin)-alanine synthase activity|beta-(9-cytokinin)alanine synthase activity|lupinate synthetase activity|lupinic acid synthase activity|lupinic acid synthetase activity http://purl.obolibrary.org/obo/GO_0050447 GO:0050440 biolink:MolecularActivity 2-methylcitrate synthase activity Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+. EC:2.3.3.5|KEGG_REACTION:R00931|MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN|RHEA:23780 go.json 2-methylcitrate oxaloacetate-lyase activity|MCS activity|methylcitrate synthase activity|methylcitrate synthetase activity|propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) http://purl.obolibrary.org/obo/GO_0050440 GO:0050441 biolink:MolecularActivity 3-ethylmalate synthase activity Catalysis of the reaction: butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H+. EC:2.3.3.7|KEGG_REACTION:R01180|MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN|RHEA:10500 go.json 2-ethyl-3-hydroxybutanedioate synthase activity|3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity|butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming) http://purl.obolibrary.org/obo/GO_0050441 GO:0050455 biolink:MolecularActivity columbamine oxidase activity Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O. EC:1.21.3.2|KEGG_REACTION:R00044|MetaCyc:COLUMBAMINE-OXIDASE-RXN|RHEA:23564 go.json berberine synthase activity|columbamine:oxygen oxidoreductase (cyclizing) http://purl.obolibrary.org/obo/GO_0050455 GO:0050456 biolink:MolecularActivity cystine reductase activity Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH. EC:1.8.1.6|KEGG_REACTION:R00892|MetaCyc:CYSTINE-REDUCTASE-NADH-RXN|RHEA:20597 go.json L-cysteine:NAD+ oxidoreductase|NADH-dependent cystine reductase activity|NADH2:L-cystine oxidoreductase|NADH:L-cystine oxidoreductase activity|cystine reductase (NADH) activity|cystine reductase (NADH2) http://purl.obolibrary.org/obo/GO_0050456 GO:0050453 biolink:MolecularActivity obsolete cob(II)alamin reductase activity OBSOLETE. Catalysis of the reaction: 2 cob(I)alamin + H+ + NAD+ = 2 cob(II)alamin + NADH. EC:1.16.1.4|KEGG_REACTION:R00099|MetaCyc:COBIIALAMIN-REDUCTASE-RXN|RHEA:17481 go.json B(12r) reductase activity|B12r reductase activity|NADH2:cob(II)alamin oxidoreductase activity|NADH:cob(II)alamin oxidoreductase activity|cob(I)alamin:NAD+ oxidoreductase activity|vitamin B(12r) reductase activity|vitamin B12 reductase activity|vitamin B12 reduction|vitamin B12r reductase activity True http://purl.obolibrary.org/obo/GO_0050453 GO:0050454 biolink:MolecularActivity coenzyme F420 hydrogenase activity Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420. EC:1.12.98.1|KEGG_REACTION:R03025|MetaCyc:COENZYME-F420-HYDROGENASE-RXN|RHEA:23760 go.json 8-hydroxy-5-deazaflavin-reducing hydrogenase activity|F420-reducing hydrogenase activity|coenzyme F420-dependent hydrogenase activity|hydrogen:coenzyme F420 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050454 GO:1902209 biolink:BiologicalProcess negative regulation of bacterial-type flagellum assembly Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum assembly. go.json down regulation of bacterial flagellum assembly|down regulation of bacterial-type flagellum assembly|down-regulation of bacterial flagellum assembly|down-regulation of bacterial-type flagellum assembly|downregulation of bacterial flagellum assembly|downregulation of bacterial-type flagellum assembly|inhibition of bacterial flagellum assembly|inhibition of bacterial-type flagellum assembly|negative regulation of bacterial flagellum assembly http://purl.obolibrary.org/obo/GO_1902209 GO:0050459 biolink:MolecularActivity ethanolamine-phosphate phospho-lyase activity Catalysis of the reaction: H2O + phosphoethanolamine = acetaldehyde + NH4 + phosphate. EC:4.2.3.2|KEGG_REACTION:R00748|MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN|RHEA:17889|Reactome:R-HSA-5696415 go.json O-phosphoethanolamine-phospholyase activity|O-phosphorylethanol-amine phospho-lyase activity|amino alcohol O-phosphate phospholyase activity|ethanolamine-phosphate phospho-lyase (deaminating)|ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming) http://purl.obolibrary.org/obo/GO_0050459 GO:1902207 biolink:BiologicalProcess positive regulation of interleukin-2-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway. go.json activation of IL-2-mediated signaling pathway|activation of interleukin-2-mediated signaling pathway|activation of interleukin-2-mediated signalling pathway|positive regulation of IL-2-mediated signaling pathway|positive regulation of interleukin-2-mediated signalling pathway|up regulation of IL-2-mediated signaling pathway|up regulation of interleukin-2-mediated signaling pathway|up regulation of interleukin-2-mediated signalling pathway|up-regulation of IL-2-mediated signaling pathway|up-regulation of interleukin-2-mediated signaling pathway|up-regulation of interleukin-2-mediated signalling pathway|upregulation of IL-2-mediated signaling pathway|upregulation of interleukin-2-mediated signaling pathway|upregulation of interleukin-2-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902207 GO:0050457 biolink:MolecularActivity decylcitrate synthase activity Catalysis of the reaction: H2O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H+. EC:2.3.3.2|KEGG_REACTION:R03735|MetaCyc:DECYLCITRATE-SYNTHASE-RXN|RHEA:16605 go.json (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity|(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)|2-decylcitrate synthase activity|dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming) http://purl.obolibrary.org/obo/GO_0050457 GO:1902208 biolink:BiologicalProcess regulation of bacterial-type flagellum assembly Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly. go.json regulation of bacterial flagellum assembly http://purl.obolibrary.org/obo/GO_1902208 GO:0050458 biolink:MolecularActivity decylhomocitrate synthase activity Catalysis of the reaction: 2-oxoglutarate + H2O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+. EC:2.3.3.4|KEGG_REACTION:R03859|MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN|RHEA:10364 go.json 2-decylhomocitrate synthase activity|3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity|3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)|dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming) http://purl.obolibrary.org/obo/GO_0050458 GO:1902205 biolink:BiologicalProcess regulation of interleukin-2-mediated signaling pathway Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway. go.json regulation of IL-2-mediated signaling pathway|regulation of interleukin-2-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902205 GO:1902206 biolink:BiologicalProcess negative regulation of interleukin-2-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway. go.json down regulation of IL-2-mediated signaling pathway|down regulation of interleukin-2-mediated signaling pathway|down regulation of interleukin-2-mediated signalling pathway|down-regulation of IL-2-mediated signaling pathway|down-regulation of interleukin-2-mediated signaling pathway|down-regulation of interleukin-2-mediated signalling pathway|downregulation of IL-2-mediated signaling pathway|downregulation of interleukin-2-mediated signaling pathway|downregulation of interleukin-2-mediated signalling pathway|inhibition of IL-2-mediated signaling pathway|inhibition of interleukin-2-mediated signaling pathway|inhibition of interleukin-2-mediated signalling pathway|negative regulation of IL-2-mediated signaling pathway|negative regulation of interleukin-2-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902206 GO:1902203 biolink:BiologicalProcess negative regulation of hepatocyte growth factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. go.json down regulation of HGF receptor signaling pathway|down regulation of HGF receptor signalling pathway|down regulation of Met signaling pathway|down regulation of hepatocyte growth factor receptor signaling pathway|down-regulation of HGF receptor signaling pathway|down-regulation of HGF receptor signalling pathway|down-regulation of Met signaling pathway|down-regulation of hepatocyte growth factor receptor signaling pathway|downregulation of HGF receptor signaling pathway|downregulation of HGF receptor signalling pathway|downregulation of Met signaling pathway|downregulation of hepatocyte growth factor receptor signaling pathway|inhibition of HGF receptor signaling pathway|inhibition of HGF receptor signalling pathway|inhibition of Met signaling pathway|inhibition of hepatocyte growth factor receptor signaling pathway|negative regulation of HGF receptor signaling pathway|negative regulation of HGF receptor signalling pathway|negative regulation of Met signaling pathway http://purl.obolibrary.org/obo/GO_1902203 GO:1902204 biolink:BiologicalProcess positive regulation of hepatocyte growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. go.json activation of HGF receptor signaling pathway|activation of HGF receptor signalling pathway|activation of Met signaling pathway|activation of hepatocyte growth factor receptor signaling pathway|positive regulation of HGF receptor signaling pathway|positive regulation of HGF receptor signalling pathway|positive regulation of Met signaling pathway|up regulation of HGF receptor signaling pathway|up regulation of HGF receptor signalling pathway|up regulation of Met signaling pathway|up regulation of hepatocyte growth factor receptor signaling pathway|up-regulation of HGF receptor signaling pathway|up-regulation of HGF receptor signalling pathway|up-regulation of Met signaling pathway|up-regulation of hepatocyte growth factor receptor signaling pathway|upregulation of HGF receptor signaling pathway|upregulation of HGF receptor signalling pathway|upregulation of Met signaling pathway|upregulation of hepatocyte growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_1902204 GO:1902201 biolink:BiologicalProcess negative regulation of bacterial-type flagellum-dependent cell motility Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. go.json down regulation of bacterial-type flagellar cell motility|down regulation of flagellin-based flagellar cell motility|down-regulation of bacterial-type flagellar cell motility|down-regulation of flagellin-based flagellar cell motility|downregulation of bacterial-type flagellar cell motility|downregulation of flagellin-based flagellar cell motility|inhibition of bacterial-type flagellar cell motility|inhibition of flagellin-based flagellar cell motility|negative regulation of bacterial-type flagellar cell motility|negative regulation of flagellin-based flagellar cell motility http://purl.obolibrary.org/obo/GO_1902201 GO:1902202 biolink:BiologicalProcess regulation of hepatocyte growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. go.json regulation of HGF receptor signaling pathway|regulation of HGF receptor signalling pathway|regulation of Met signaling pathway http://purl.obolibrary.org/obo/GO_1902202 GO:1902200 biolink:BiologicalProcess 3-methylbut-2-enoyl-CoA(4-) biosynthetic process The chemical reactions and pathways resulting in the formation of 3-methylbut-2-enoyl-CoA(4-). go.json 3-methylbut-2-enoyl-CoA(4-) anabolism|3-methylbut-2-enoyl-CoA(4-) biosynthesis|3-methylbut-2-enoyl-CoA(4-) formation|3-methylbut-2-enoyl-CoA(4-) synthesis http://purl.obolibrary.org/obo/GO_1902200 GO:0050451 biolink:MolecularActivity CoA-disulfide reductase (NADP) activity Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+. EC:1.8.1.14|MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN|RHEA:14705 go.json CoA-disulfide reductase (NADH) activity|CoA-disulfide reductase activity|CoA-disulphide reductase activity|CoADR activity|NADH:CoA-disulfide oxidoreductase activity|coenzyme A disulfide reductase activity http://purl.obolibrary.org/obo/GO_0050451 GO:0050452 biolink:MolecularActivity CoA-glutathione reductase (NADP) activity Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+. EC:1.8.1.10|MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN|RHEA:14617 go.json CoA-glutathione reductase (NADPH) activity|CoA-glutathione reductase activity|NADPH-dependent coenzyme A-SS-glutathione reductase activity|NADPH:CoA-glutathione oxidoreductase activity|coenzyme A disulfide-glutathione reductase activity|coenzyme A glutathione disulfide reductase activity|glutathione:NADP+ oxidoreductase (CoA-acylating) http://purl.obolibrary.org/obo/GO_0050452 GO:0050450 biolink:MolecularActivity citrate (Re)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group. EC:2.3.3.3|MetaCyc:CITSYN-RXN go.json (R)-citrate synthase activity|Re-citrate-synthase activity|acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]|citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity|citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA] http://purl.obolibrary.org/obo/GO_0050450 GO:0050466 biolink:MolecularActivity obsolete oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen. go.json oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors True http://purl.obolibrary.org/obo/GO_0050466 GO:0050467 biolink:MolecularActivity pentalenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene. EC:4.2.3.7|KEGG_REACTION:R02305|MetaCyc:PENTALENENE-SYNTHASE-RXN|RHEA:18081 go.json 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)|2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)|pentalenene synthetase activity http://purl.obolibrary.org/obo/GO_0050467 GO:0050464 biolink:MolecularActivity nitrate reductase (NADPH) activity Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+. EC:1.7.1.3|MetaCyc:NITRATE-REDUCTASE-NADPH-RXN|RHEA:19061 go.json NADPH-nitrate reductase activity|NADPH:nitrate oxidoreductase activity|NADPH:nitrate reductase activity|assimilatory NADPH-nitrate reductase activity|assimilatory nitrate reductase activity|assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity|nitrate reductase (NADPH(2)) activity|nitrate reductase (NADPH2)|nitrite:NADP+ oxidoreductase activity|triphosphopyridine nucleotide-nitrate reductase activity http://purl.obolibrary.org/obo/GO_0050464 GO:0050465 biolink:MolecularActivity nitroquinoline-N-oxide reductase activity Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. EC:1.7.1.9|MetaCyc:1.7.1.9-RXN go.json 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity|4-nitroquinoline 1-oxide reductase activity|4NQO reductase activity|NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity|NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050465 GO:0050468 biolink:MolecularActivity reticuline oxidase activity Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2 + H+. EC:1.21.3.3|KEGG_REACTION:R03831|MetaCyc:RETICULINE-OXIDASE-RXN|RHEA:19885 go.json (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)|BBE|berberine bridge enzyme activity|berberine-bridge-forming enzyme activity|tetrahydroprotoberberine synthase activity http://purl.obolibrary.org/obo/GO_0050468 GO:1902218 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. go.json http://purl.obolibrary.org/obo/GO_1902218 GO:1902219 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. go.json down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress|inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress http://purl.obolibrary.org/obo/GO_1902219 GO:0050469 biolink:MolecularActivity sabinene-hydrate synthase activity Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate. EC:4.2.3.11|KEGG_REACTION:R02006|MetaCyc:4.2.3.11-RXN|RHEA:19565 go.json geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)|sabinene hydrate cyclase activity http://purl.obolibrary.org/obo/GO_0050469 GO:1902216 biolink:BiologicalProcess positive regulation of interleukin-4-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway. go.json activation of IL-4-mediated signaling pathway|activation of interleukin-4-mediated signaling pathway|activation of interleukin-4-mediated signalling pathway|positive regulation of IL-4-mediated signaling pathway|positive regulation of interleukin-4-mediated signalling pathway|up regulation of IL-4-mediated signaling pathway|up regulation of interleukin-4-mediated signaling pathway|up regulation of interleukin-4-mediated signalling pathway|up-regulation of IL-4-mediated signaling pathway|up-regulation of interleukin-4-mediated signaling pathway|up-regulation of interleukin-4-mediated signalling pathway|upregulation of IL-4-mediated signaling pathway|upregulation of interleukin-4-mediated signaling pathway|upregulation of interleukin-4-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902216 GO:1902217 biolink:BiologicalProcess erythrocyte apoptotic process Any apoptotic process in an erythrocyte. go.json RBC apoptosis|RBC apoptotic process|erythrocyte apoptosis|red blood cell apoptosis|red blood cell apoptotic process http://purl.obolibrary.org/obo/GO_1902217 GO:1902214 biolink:BiologicalProcess regulation of interleukin-4-mediated signaling pathway Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway. go.json regulation of IL-4-mediated signaling pathway|regulation of interleukin-4-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902214 GO:1902215 biolink:BiologicalProcess negative regulation of interleukin-4-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway. go.json down regulation of IL-4-mediated signaling pathway|down regulation of interleukin-4-mediated signaling pathway|down regulation of interleukin-4-mediated signalling pathway|down-regulation of IL-4-mediated signaling pathway|down-regulation of interleukin-4-mediated signaling pathway|down-regulation of interleukin-4-mediated signalling pathway|downregulation of IL-4-mediated signaling pathway|downregulation of interleukin-4-mediated signaling pathway|downregulation of interleukin-4-mediated signalling pathway|inhibition of IL-4-mediated signaling pathway|inhibition of interleukin-4-mediated signaling pathway|inhibition of interleukin-4-mediated signalling pathway|negative regulation of IL-4-mediated signaling pathway|negative regulation of interleukin-4-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902215 GO:1902212 biolink:BiologicalProcess negative regulation of prolactin signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway. go.json down regulation of PRL signaling pathway|down regulation of prolactin signaling pathway|down regulation of prolactin-mediated signaling pathway|down-regulation of PRL signaling pathway|down-regulation of prolactin signaling pathway|down-regulation of prolactin-mediated signaling pathway|downregulation of PRL signaling pathway|downregulation of prolactin signaling pathway|downregulation of prolactin-mediated signaling pathway|inhibition of PRL signaling pathway|inhibition of prolactin signaling pathway|inhibition of prolactin-mediated signaling pathway|negative regulation of PRL signaling pathway|negative regulation of prolactin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902212 GO:1902213 biolink:BiologicalProcess positive regulation of prolactin signaling pathway Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway. go.json activation of PRL signaling pathway|activation of prolactin signaling pathway|activation of prolactin-mediated signaling pathway|positive regulation of PRL signaling pathway|positive regulation of prolactin-mediated signaling pathway|up regulation of PRL signaling pathway|up regulation of prolactin signaling pathway|up regulation of prolactin-mediated signaling pathway|up-regulation of PRL signaling pathway|up-regulation of prolactin signaling pathway|up-regulation of prolactin-mediated signaling pathway|upregulation of PRL signaling pathway|upregulation of prolactin signaling pathway|upregulation of prolactin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902213 GO:1902210 biolink:BiologicalProcess positive regulation of bacterial-type flagellum assembly Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly. go.json activation of bacterial flagellum assembly|activation of bacterial-type flagellum assembly|positive regulation of bacterial flagellum assembly|up regulation of bacterial flagellum assembly|up regulation of bacterial-type flagellum assembly|up-regulation of bacterial flagellum assembly|up-regulation of bacterial-type flagellum assembly|upregulation of bacterial flagellum assembly|upregulation of bacterial-type flagellum assembly http://purl.obolibrary.org/obo/GO_1902210 GO:1902211 biolink:BiologicalProcess regulation of prolactin signaling pathway Any process that modulates the frequency, rate or extent of prolactin signaling pathway. go.json regulation of PRL signaling pathway|regulation of prolactin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902211 GO:1902220 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. go.json activation of intrinsic apoptotic signaling pathway in response to osmotic stress|up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress http://purl.obolibrary.org/obo/GO_1902220 GO:0050462 biolink:MolecularActivity N-acetylneuraminate synthase activity Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate. EC:2.5.1.56|MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN|RHEA:19273 go.json (NANA)condensing enzyme activity|N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity|N-acetylneuraminic acid synthase activity|NeuAc synthase activity|phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) http://purl.obolibrary.org/obo/GO_0050462 GO:0050463 biolink:MolecularActivity nitrate reductase [NAD(P)H] activity Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+. EC:1.7.1.2 go.json NAD(P)H bispecific nitrate reductase activity|NAD(P)H-nitrate reductase activity|NAD(P)H2:nitrate oxidoreductase activity|NAD(P)H:nitrate oxidoreductase activity|assimilatory NAD(P)H-nitrate reductase activity|assimilatory nitrate reductase activity|nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity|nitrate reductase NAD(P)H activity|nitrate reductase [NAD(P)H2]|nitrite:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050463 GO:0050460 biolink:MolecularActivity hydroxylamine reductase (NADH) activity Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+. EC:1.7.1.10|MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN|RHEA:20581 go.json N-hydroxy amine reductase activity|NADH-hydroxylamine reductase activity|NADH2:hydroxylamine oxidoreductase activity|NADH:hydroxylamine oxidoreductase activity|ammonium dehydrogenase activity|ammonium:NAD+ oxidoreductase activity|hydroxylamine reductase (NADH2) http://purl.obolibrary.org/obo/GO_0050460 GO:0050461 biolink:MolecularActivity L-mimosine synthase activity Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate. EC:2.5.1.52|KEGG_REACTION:R04091|MetaCyc:RXN-7461|RHEA:12693 go.json 3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity|O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity|O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)|O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity http://purl.obolibrary.org/obo/GO_0050461 GO:0050477 biolink:MolecularActivity acyl-lysine deacylase activity Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate. EC:3.5.1.17|MetaCyc:ACYL-LYSINE-DEACYLASE-RXN|RHEA:24548 go.json 6-N-acyl-L-lysine amidohydrolase activity|N6-acyl-L-lysine amidohydrolase activity|epsilon-lysine acylase activity http://purl.obolibrary.org/obo/GO_0050477 GO:0050478 biolink:MolecularActivity obsolete anthranilate 3-monooxygenase activity OBSOLETE. Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O2 = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H2O. go.json anthranilate 3-hydroxylase activity|anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|anthranilic acid hydroxylase activity True http://purl.obolibrary.org/obo/GO_0050478 GO:0050475 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050475 GO:0050476 biolink:MolecularActivity acetylenedicarboxylate decarboxylase activity Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate. EC:4.1.1.78|MetaCyc:4.1.1.78-RXN|RHEA:17733 go.json acetylenedicarboxylate carboxy-lyase (pyruvate-forming)|acetylenedicarboxylate carboxy-lyase activity|acetylenedicarboxylate hydrase activity|acetylenedicarboxylate hydratase activity http://purl.obolibrary.org/obo/GO_0050476 GO:0050479 biolink:MolecularActivity glyceryl-ether monooxygenase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). EC:1.14.16.5|MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN|RHEA:36255|Reactome:R-HSA-5696119 go.json 1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity|O-alkylglycerol monooxygenase activity|alkylglycerol monooxygenase activity|glyceryl ether oxygenase activity|glyceryl etherase activity|glyceryl-ether cleaving enzyme activity http://purl.obolibrary.org/obo/GO_0050479 GO:1902229 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway in response to DNA damage Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. go.json regulation of DNA damage response, signal transduction resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902229 GO:1902227 biolink:BiologicalProcess negative regulation of macrophage colony-stimulating factor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. go.json down regulation of M-CSF signaling pathway|down regulation of macrophage colony-stimulating factor signaling pathway|down regulation of macrophage colony-stimulating factor signalling pathway|down-regulation of M-CSF signaling pathway|down-regulation of macrophage colony-stimulating factor signaling pathway|down-regulation of macrophage colony-stimulating factor signalling pathway|downregulation of M-CSF signaling pathway|downregulation of macrophage colony-stimulating factor signaling pathway|downregulation of macrophage colony-stimulating factor signalling pathway|inhibition of M-CSF signaling pathway|inhibition of macrophage colony-stimulating factor signaling pathway|inhibition of macrophage colony-stimulating factor signalling pathway|negative regulation of M-CSF signaling pathway|negative regulation of macrophage colony-stimulating factor signalling pathway http://purl.obolibrary.org/obo/GO_1902227 GO:1902228 biolink:BiologicalProcess positive regulation of macrophage colony-stimulating factor signaling pathway Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. go.json activation of M-CSF signaling pathway|activation of macrophage colony-stimulating factor signaling pathway|activation of macrophage colony-stimulating factor signalling pathway|positive regulation of M-CSF signaling pathway|positive regulation of macrophage colony-stimulating factor signalling pathway|up regulation of M-CSF signaling pathway|up regulation of macrophage colony-stimulating factor signaling pathway|up regulation of macrophage colony-stimulating factor signalling pathway|up-regulation of M-CSF signaling pathway|up-regulation of macrophage colony-stimulating factor signaling pathway|up-regulation of macrophage colony-stimulating factor signalling pathway|upregulation of M-CSF signaling pathway|upregulation of macrophage colony-stimulating factor signaling pathway|upregulation of macrophage colony-stimulating factor signalling pathway http://purl.obolibrary.org/obo/GO_1902228 GO:1902225 biolink:BiologicalProcess negative regulation of acrosome reaction Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction. go.json down regulation of acrosome reaction|down-regulation of acrosome reaction|downregulation of acrosome reaction|inhibition of acrosome reaction http://purl.obolibrary.org/obo/GO_1902225 GO:1902226 biolink:BiologicalProcess regulation of macrophage colony-stimulating factor signaling pathway Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. go.json regulation of M-CSF signaling pathway|regulation of macrophage colony-stimulating factor signalling pathway http://purl.obolibrary.org/obo/GO_1902226 GO:1902223 biolink:BiologicalProcess erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. go.json erythrose 4-phosphate/phosphoenolpyruvate family amino acid anabolism|erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthesis|erythrose 4-phosphate/phosphoenolpyruvate family amino acid formation|erythrose 4-phosphate/phosphoenolpyruvate family amino acid synthesis http://purl.obolibrary.org/obo/GO_1902223 GO:1902224 biolink:BiologicalProcess ketone body metabolic process The chemical reactions and pathways involving ketone body. go.json ketone body metabolism http://purl.obolibrary.org/obo/GO_1902224 GO:1902221 biolink:BiologicalProcess erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. go.json erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism http://purl.obolibrary.org/obo/GO_1902221 GO:1902222 biolink:BiologicalProcess erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. go.json erythrose 4-phosphate/phosphoenolpyruvate family amino acid breakdown|erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolism|erythrose 4-phosphate/phosphoenolpyruvate family amino acid degradation http://purl.obolibrary.org/obo/GO_1902222 GO:1902230 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. go.json down regulation of DNA damage response, signal transduction resulting in induction of apoptosis|down regulation of intrinsic apoptotic signaling pathway in response to DNA damage|down-regulation of DNA damage response, signal transduction resulting in induction of apoptosis|down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage|downregulation of DNA damage response, signal transduction resulting in induction of apoptosis|downregulation of intrinsic apoptotic signaling pathway in response to DNA damage|inhibition of DNA damage response, signal transduction resulting in induction of apoptosis|inhibition of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of DNA damage response, signal transduction resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902230 GO:1902231 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. go.json activation of DNA damage response, signal transduction resulting in induction of apoptosis|activation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of DNA damage response, signal transduction resulting in induction of apoptosis|up regulation of DNA damage response, signal transduction resulting in induction of apoptosis|up regulation of intrinsic apoptotic signaling pathway in response to DNA damage|up-regulation of DNA damage response, signal transduction resulting in induction of apoptosis|up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage|upregulation of DNA damage response, signal transduction resulting in induction of apoptosis|upregulation of intrinsic apoptotic signaling pathway in response to DNA damage http://purl.obolibrary.org/obo/GO_1902231 GO:0050470 biolink:MolecularActivity trimethylamine dehydrogenase activity Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein. EC:1.5.8.2|MetaCyc:1.5.8.2-RXN|RHEA:11864|UM-BBD_enzymeID:e0854 go.json TMADh activity|trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating) http://purl.obolibrary.org/obo/GO_0050470 GO:0050473 biolink:MolecularActivity arachidonate 15-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. EC:1.13.11.33|MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN|RHEA:16869|Reactome:R-HSA-2161951|Reactome:R-HSA-2162002|Reactome:R-HSA-9018907|Reactome:R-HSA-9020261|Reactome:R-HSA-9020262|Reactome:R-HSA-9020275|Reactome:R-HSA-9020610|Reactome:R-HSA-9024872|Reactome:R-HSA-9024881|Reactome:R-HSA-9025152|Reactome:R-HSA-9026003|Reactome:R-HSA-9027532|Reactome:R-HSA-9027607|Reactome:R-HSA-9027627|Reactome:R-HSA-9028255 go.json 15-lipoxygenase activity|arachidonate omega(6) lipoxygenase activity|arachidonate omega6 lipoxygenase activity|arachidonate:oxygen 15-oxidoreductase activity|linoleic acid omega6-lipoxygenase activity|omega6 lipoxygenase activity http://purl.obolibrary.org/obo/GO_0050473 GO:0050474 biolink:MolecularActivity (S)-norcoclaurine synthase activity Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O. EC:4.2.1.78|MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN|RHEA:16173 go.json (S)-norlaudanosoline synthase activity|4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)|4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming] http://purl.obolibrary.org/obo/GO_0050474 GO:0050471 biolink:MolecularActivity uracilylalanine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate. EC:2.5.1.53|MetaCyc:RXN-7541|RHEA:11496 go.json 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity|O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity|O3-acetyl-L-serine acetate-lyase (adding uracil)|O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity|Willardiine synthase activity|isowillardiine synthase activity http://purl.obolibrary.org/obo/GO_0050471 GO:0050472 biolink:MolecularActivity zeatin reductase activity Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin. EC:1.3.1.69|KEGG_REACTION:R05702|MetaCyc:ZEATIN-REDUCTASE-RXN|RHEA:12757 go.json dihydrozeatin:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050472 GO:0050488 biolink:MolecularActivity ecdysteroid UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid. go.json ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity http://purl.obolibrary.org/obo/GO_0050488 GO:0050489 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050489 GO:0050486 biolink:MolecularActivity intramolecular hydroxytransferase activity Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule. EC:5.4.4.- go.json intramolecular transferase activity, transferring hydroxy groups http://purl.obolibrary.org/obo/GO_0050486 GO:0050487 biolink:MolecularActivity sulfoacetaldehyde acetyltransferase activity Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde. EC:2.3.3.15|KEGG_REACTION:R05651|MetaCyc:RXN-2364|RHEA:24204 go.json acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)|sulphoacetaldehyde acetyltransferase activity http://purl.obolibrary.org/obo/GO_0050487 GO:1902238 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. go.json http://purl.obolibrary.org/obo/GO_1902238 GO:1902239 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. go.json down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator http://purl.obolibrary.org/obo/GO_1902239 GO:1902236 biolink:BiologicalProcess negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. go.json down regulation of ER stress-induced apoptosis|down regulation of apoptosis in response to ER stress|down regulation of apoptosis triggered by ER stress|down regulation of endoplasmic reticulum stress-induced apoptosis|down regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|down regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|down-regulation of ER stress-induced apoptosis|down-regulation of apoptosis in response to ER stress|down-regulation of apoptosis triggered by ER stress|down-regulation of endoplasmic reticulum stress-induced apoptosis|down-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|down-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|downregulation of ER stress-induced apoptosis|downregulation of apoptosis in response to ER stress|downregulation of apoptosis triggered by ER stress|downregulation of endoplasmic reticulum stress-induced apoptosis|downregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|downregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|inhibition of ER stress-induced apoptosis|inhibition of apoptosis in response to ER stress|inhibition of apoptosis triggered by ER stress|inhibition of endoplasmic reticulum stress-induced apoptosis|inhibition of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inhibition of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|negative regulation of ER stress-induced apoptosis|negative regulation of apoptosis in response to ER stress|negative regulation of apoptosis triggered by ER stress|negative regulation of endoplasmic reticulum stress-induced apoptosis|negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1902236 GO:1902237 biolink:BiologicalProcess positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. go.json activation of ER stress-induced apoptosis|activation of apoptosis in response to ER stress|activation of apoptosis triggered by ER stress|activation of endoplasmic reticulum stress-induced apoptosis|activation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|activation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|positive regulation of ER stress-induced apoptosis|positive regulation of apoptosis in response to ER stress|positive regulation of apoptosis triggered by ER stress|positive regulation of endoplasmic reticulum stress-induced apoptosis|positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|up regulation of ER stress-induced apoptosis|up regulation of apoptosis in response to ER stress|up regulation of apoptosis triggered by ER stress|up regulation of endoplasmic reticulum stress-induced apoptosis|up regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|up regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|up-regulation of ER stress-induced apoptosis|up-regulation of apoptosis in response to ER stress|up-regulation of apoptosis triggered by ER stress|up-regulation of endoplasmic reticulum stress-induced apoptosis|up-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|up-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|upregulation of ER stress-induced apoptosis|upregulation of apoptosis in response to ER stress|upregulation of apoptosis triggered by ER stress|upregulation of endoplasmic reticulum stress-induced apoptosis|upregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|upregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1902237 GO:1902234 biolink:BiologicalProcess positive regulation of positive thymic T cell selection Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection. go.json activation of positive thymic T cell selection|activation of positive thymic T lymphocyte selection|activation of positive thymic T-cell selection|activation of positive thymic T-lymphocyte selection|positive regulation of positive thymic T lymphocyte selection|positive regulation of positive thymic T-cell selection|positive regulation of positive thymic T-lymphocyte selection|up regulation of positive thymic T cell selection|up regulation of positive thymic T lymphocyte selection|up regulation of positive thymic T-cell selection|up regulation of positive thymic T-lymphocyte selection|up-regulation of positive thymic T cell selection|up-regulation of positive thymic T lymphocyte selection|up-regulation of positive thymic T-cell selection|up-regulation of positive thymic T-lymphocyte selection|upregulation of positive thymic T cell selection|upregulation of positive thymic T lymphocyte selection|upregulation of positive thymic T-cell selection|upregulation of positive thymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_1902234 GO:1902235 biolink:BiologicalProcess regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. go.json regulation of ER stress-induced apoptosis|regulation of apoptosis in response to ER stress|regulation of apoptosis in response to endoplasmic reticulum stress|regulation of apoptosis triggered by ER stress|regulation of endoplasmic reticulum stress-induced apoptosis|regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1902235 GO:1902232 biolink:BiologicalProcess regulation of positive thymic T cell selection Any process that modulates the frequency, rate or extent of positive thymic T cell selection. go.json regulation of positive thymic T lymphocyte selection|regulation of positive thymic T-cell selection|regulation of positive thymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_1902232 GO:1902233 biolink:BiologicalProcess negative regulation of positive thymic T cell selection Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection. go.json down regulation of positive thymic T cell selection|down regulation of positive thymic T lymphocyte selection|down regulation of positive thymic T-cell selection|down regulation of positive thymic T-lymphocyte selection|down-regulation of positive thymic T cell selection|down-regulation of positive thymic T lymphocyte selection|down-regulation of positive thymic T-cell selection|down-regulation of positive thymic T-lymphocyte selection|downregulation of positive thymic T cell selection|downregulation of positive thymic T lymphocyte selection|downregulation of positive thymic T-cell selection|downregulation of positive thymic T-lymphocyte selection|inhibition of positive thymic T cell selection|inhibition of positive thymic T lymphocyte selection|inhibition of positive thymic T-cell selection|inhibition of positive thymic T-lymphocyte selection|negative regulation of positive thymic T lymphocyte selection|negative regulation of positive thymic T-cell selection|negative regulation of positive thymic T-lymphocyte selection http://purl.obolibrary.org/obo/GO_1902233 GO:1902241 biolink:BiologicalProcess copal-8-ol diphosphate(3-) metabolic process The chemical reactions and pathways involving copal-8-ol diphosphate(3-). go.json copal-8-ol diphosphate(3-) metabolism http://purl.obolibrary.org/obo/GO_1902241 GO:1902242 biolink:BiologicalProcess copal-8-ol diphosphate(3-) catabolic process The chemical reactions and pathways resulting in the breakdown of copal-8-ol diphosphate(3-). go.json copal-8-ol diphosphate(3-) breakdown|copal-8-ol diphosphate(3-) catabolism|copal-8-ol diphosphate(3-) degradation http://purl.obolibrary.org/obo/GO_1902242 GO:1902240 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. go.json activation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator http://purl.obolibrary.org/obo/GO_1902240 GO:0050480 biolink:MolecularActivity imidazolonepropionase activity Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+. EC:3.5.2.7|KEGG_REACTION:R02288|MetaCyc:IMIDAZOLONEPROPIONASE-RXN|RHEA:23660 go.json 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity|4(5)-imidazolone-5(4)-propionic acid hydrolase activity|imidazolone propionic acid hydrolase activity|imidazolone-5-propionate hydrolase activity http://purl.obolibrary.org/obo/GO_0050480 GO:0050481 biolink:MolecularActivity mandelate 4-monooxygenase activity Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H2O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate. EC:1.14.16.6|KEGG_REACTION:R03794|MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN|RHEA:21716 go.json (S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)|L-mandelate 4-hydroxylase activity|mandelic acid 4-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050481 GO:0050484 biolink:MolecularActivity GMP 5'-nucleotidase activity Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate. MetaCyc:RXN-7609|RHEA:27714 go.json GMP 5' nucleotidase activity|IMP-GMP specific 5'-nucleotidase activity http://purl.obolibrary.org/obo/GO_0050484 GO:0050485 biolink:MolecularActivity oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide. EC:1.21.4.- go.json oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor http://purl.obolibrary.org/obo/GO_0050485 GO:0050482 biolink:BiologicalProcess arachidonic acid secretion The controlled release of arachidonic acid from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0050482 GO:0050483 biolink:MolecularActivity IMP 5'-nucleotidase activity Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate. MetaCyc:RXN-7607|RHEA:27718 go.json IMP 5' nucleotidase activity|IMP-GMP specific 5'-nucleotidase activity http://purl.obolibrary.org/obo/GO_0050483 GO:0050499 biolink:MolecularActivity oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H. EC:1.20.1.- go.json http://purl.obolibrary.org/obo/GO_0050499 GO:0050497 biolink:MolecularActivity alkylthioltransferase activity Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor). EC:2.8.4.- go.json transferase activity, transferring alkylthio groups http://purl.obolibrary.org/obo/GO_0050497 GO:0050498 biolink:MolecularActivity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated. EC:1.14.20.- go.json http://purl.obolibrary.org/obo/GO_0050498 GO:1902249 biolink:MolecularActivity IMP binding Binding to IMP, inosine monophosphate. go.json http://purl.obolibrary.org/obo/GO_1902249 GO:1902247 biolink:BiologicalProcess geranylgeranyl diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of geranylgeranyl diphosphate. go.json geranylgeranyl diphosphate breakdown|geranylgeranyl diphosphate catabolism|geranylgeranyl diphosphate degradation http://purl.obolibrary.org/obo/GO_1902247 GO:1902248 biolink:MolecularActivity 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate. go.json 5-phosphoribose 1-diphosphate binding|phosphoribosylpyrophosphate binding http://purl.obolibrary.org/obo/GO_1902248 GO:1902245 biolink:BiologicalProcess cis-abienol catabolic process The chemical reactions and pathways resulting in the breakdown of cis-abienol. go.json cis-abienol breakdown|cis-abienol catabolism|cis-abienol degradation http://purl.obolibrary.org/obo/GO_1902245 GO:1902246 biolink:BiologicalProcess cis-abienol biosynthetic process The chemical reactions and pathways resulting in the formation of cis-abienol. go.json cis-abienol anabolism|cis-abienol biosynthesis|cis-abienol formation|cis-abienol synthesis http://purl.obolibrary.org/obo/GO_1902246 GO:1902243 biolink:BiologicalProcess copal-8-ol diphosphate(3-) biosynthetic process The chemical reactions and pathways resulting in the formation of copal-8-ol diphosphate(3-). go.json copal-8-ol diphosphate(3-) anabolism|copal-8-ol diphosphate(3-) biosynthesis|copal-8-ol diphosphate(3-) formation|copal-8-ol diphosphate(3-) synthesis http://purl.obolibrary.org/obo/GO_1902243 GO:1902244 biolink:BiologicalProcess cis-abienol metabolic process The chemical reactions and pathways involving cis-abienol. go.json cis-abienol metabolism http://purl.obolibrary.org/obo/GO_1902244 GO:1902252 biolink:BiologicalProcess positive regulation of erythrocyte apoptotic process Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. go.json activation of RBC apoptosis|activation of RBC apoptotic process|activation of erythrocyte apoptosis|activation of erythrocyte apoptotic process|activation of red blood cell apoptosis|activation of red blood cell apoptotic process|positive regulation of RBC apoptosis|positive regulation of RBC apoptotic process|positive regulation of erythrocyte apoptosis|positive regulation of red blood cell apoptosis|positive regulation of red blood cell apoptotic process|up regulation of RBC apoptosis|up regulation of RBC apoptotic process|up regulation of erythrocyte apoptosis|up regulation of erythrocyte apoptotic process|up regulation of red blood cell apoptosis|up regulation of red blood cell apoptotic process|up-regulation of RBC apoptosis|up-regulation of RBC apoptotic process|up-regulation of erythrocyte apoptosis|up-regulation of erythrocyte apoptotic process|up-regulation of red blood cell apoptosis|up-regulation of red blood cell apoptotic process|upregulation of RBC apoptosis|upregulation of RBC apoptotic process|upregulation of erythrocyte apoptosis|upregulation of erythrocyte apoptotic process|upregulation of red blood cell apoptosis|upregulation of red blood cell apoptotic process http://purl.obolibrary.org/obo/GO_1902252 GO:1902253 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway by p53 class mediator Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. go.json regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|regulation of signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902253 GO:1902250 biolink:BiologicalProcess regulation of erythrocyte apoptotic process Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. go.json regulation of RBC apoptosis|regulation of RBC apoptotic process|regulation of erythrocyte apoptosis|regulation of red blood cell apoptosis|regulation of red blood cell apoptotic process http://purl.obolibrary.org/obo/GO_1902250 GO:1902251 biolink:BiologicalProcess negative regulation of erythrocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. go.json down regulation of RBC apoptosis|down regulation of RBC apoptotic process|down regulation of erythrocyte apoptosis|down regulation of erythrocyte apoptotic process|down regulation of red blood cell apoptosis|down regulation of red blood cell apoptotic process|down-regulation of RBC apoptosis|down-regulation of RBC apoptotic process|down-regulation of erythrocyte apoptosis|down-regulation of erythrocyte apoptotic process|down-regulation of red blood cell apoptosis|down-regulation of red blood cell apoptotic process|downregulation of RBC apoptosis|downregulation of RBC apoptotic process|downregulation of erythrocyte apoptosis|downregulation of erythrocyte apoptotic process|downregulation of red blood cell apoptosis|downregulation of red blood cell apoptotic process|inhibition of RBC apoptosis|inhibition of RBC apoptotic process|inhibition of erythrocyte apoptosis|inhibition of erythrocyte apoptotic process|inhibition of red blood cell apoptosis|inhibition of red blood cell apoptotic process|negative regulation of RBC apoptosis|negative regulation of RBC apoptotic process|negative regulation of erythrocyte apoptosis|negative regulation of red blood cell apoptosis|negative regulation of red blood cell apoptotic process http://purl.obolibrary.org/obo/GO_1902251 GO:0050491 biolink:MolecularActivity sulcatone reductase activity Catalysis of the reaction: NAD+ + sulcatol = H+ + NADH + sulcatone. EC:1.1.1.260|KEGG_REACTION:R05678|MetaCyc:1.1.1.260-RXN|RHEA:24484 go.json sulcatol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050491 GO:0050492 biolink:MolecularActivity glycerol-1-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate. EC:1.1.1.261|MetaCyc:1.1.1.261-RXN go.json sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050492 GO:0050490 biolink:MolecularActivity 1,4-lactonase activity Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid. EC:3.1.1.25|MetaCyc:14-LACTONASE-RXN|RHEA:12745 go.json 1,4-lactone hydroxyacylhydrolase activity|gamma-lactonase activity http://purl.obolibrary.org/obo/GO_0050490 GO:0050495 biolink:BiologicalProcess peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine. RESID:AA0346 go.json peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine|peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine|peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine http://purl.obolibrary.org/obo/GO_0050495 gocheck_do_not_annotate GO:0050496 biolink:BiologicalProcess peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide. RESID:AA0340 go.json peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine|peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine|peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine http://purl.obolibrary.org/obo/GO_0050496 gocheck_do_not_annotate GO:0050493 biolink:BiologicalProcess GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0164 go.json GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0050493 gocheck_do_not_annotate GO:0050494 biolink:BiologicalProcess GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0165 go.json GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine|GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine|GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine http://purl.obolibrary.org/obo/GO_0050494 gocheck_do_not_annotate GO:1990794 biolink:CellularComponent basolateral part of cell The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells. go.json http://purl.obolibrary.org/obo/GO_1990794 GO:1990795 biolink:CellularComponent rod bipolar cell terminal bouton A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer. go.json http://purl.obolibrary.org/obo/GO_1990795 GO:1990796 biolink:CellularComponent photoreceptor cell terminal bouton A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light. go.json http://purl.obolibrary.org/obo/GO_1990796 GO:1990797 biolink:BiologicalProcess obsolete cholecystokinin secretion OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain. go.json CCK secretion True http://purl.obolibrary.org/obo/GO_1990797 GO:1990790 biolink:BiologicalProcess response to glial cell derived neurotrophic factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. go.json response to ATF|response to GDNF|response to astrocyte-derived trophic factor http://purl.obolibrary.org/obo/GO_1990790 GO:1990791 biolink:BiologicalProcess dorsal root ganglion development The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. go.json DRG development http://purl.obolibrary.org/obo/GO_1990791 GO:1990792 biolink:BiologicalProcess cellular response to glial cell derived neurotrophic factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. go.json cellular response to ATF|cellular response to GDNF|cellular response to astrocyte-derived trophic factor http://purl.obolibrary.org/obo/GO_1990792 GO:1990793 biolink:BiologicalProcess substance P secretion, neurotransmission The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_1990793 GO:1990798 biolink:BiologicalProcess pancreas regeneration The regrowth of a destroyed pancreas. go.json http://purl.obolibrary.org/obo/GO_1990798 GO:1990799 biolink:BiologicalProcess mitochondrial tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. go.json http://purl.obolibrary.org/obo/GO_1990799 GO:0050400 biolink:MolecularActivity xylitol kinase activity Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate. EC:2.7.1.122|KEGG_REACTION:R02136|MetaCyc:XYLITOL-KINASE-RXN|RHEA:20209 go.json ATP:xylitol 5-phosphotransferase activity|xylitol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050400 GO:0050401 biolink:MolecularActivity xylonate dehydratase activity Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O. EC:4.2.1.82|KEGG_REACTION:R02429|MetaCyc:XYLONATE-DEHYDRATASE-RXN|RHEA:19157 go.json D-xylo-aldonate dehydratase activity|D-xylonate dehydratase activity|D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)|D-xylonate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050401 GO:0050404 biolink:MolecularActivity zeatin O-beta-D-xylosyltransferase activity Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP. EC:2.4.2.40|KEGG_REACTION:R02119|MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN|RHEA:14721 go.json UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity|uridine diphosphoxylose-zeatin xylosyltransferase activity|zeatin O-b-D-xylosyltransferase activity|zeatin O-xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0050404 GO:0050405 biolink:MolecularActivity [acetyl-CoA carboxylase] kinase activity Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. EC:2.7.11.27|MetaCyc:2.7.11.27-RXN|RHEA:20333 go.json ACK2|ACK3|AMPK|ATP:acetyl-CoA carboxylase phosphotransferase activity|I-peptide kinase activity|STK5|acetyl coenzyme A carboxylase kinase (phosphorylating) activity|acetyl-CoA carboxylase bound kinase activity|acetyl-CoA carboxylase kinase (AMP-activated) activity|acetyl-CoA carboxylase kinase (cAMP-independent) activity|acetyl-CoA carboxylase kinase 2 activity|acetyl-CoA carboxylase kinase activity|acetyl-CoA carboxylase kinase-2 activity|acetyl-CoA carboxylase kinase-3 (AMP-activated) activity|acetyl-coenzyme A carboxylase kinase activity http://purl.obolibrary.org/obo/GO_0050405 GO:0050402 biolink:MolecularActivity xylono-1,4-lactonase activity Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate. EC:3.1.1.68|MetaCyc:RXN-19753|RHEA:18341 go.json D-xylono-1,4-lactone lactonohydrolase activity|xylono-g-lactonase activity|xylonolactonase activity http://purl.obolibrary.org/obo/GO_0050402 GO:0050403 biolink:MolecularActivity trans-zeatin O-beta-D-glucosyltransferase activity Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H+ + UDP. EC:2.4.1.203|KEGG_REACTION:R02118|MetaCyc:RXN-4723|RHEA:23224 go.json UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity|UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-zeatin O-glucosyltransferase activity|zeatin O-b-D-glucosyltransferase activity|zeatin O-beta-D-glucosyltransferase activity|zeatin O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050403 GO:0050408 biolink:MolecularActivity [pyruvate kinase]-phosphatase activity Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate. EC:3.1.3.49|MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN go.json ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity|pyruvate kinase phosphatase activity|pyruvate kinase-phosphatase activity http://purl.obolibrary.org/obo/GO_0050408 GO:0050409 biolink:MolecularActivity indolylacetylinositol arabinosyltransferase activity Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP. EC:2.4.2.34|KEGG_REACTION:R04335|MetaCyc:2.4.2.34-RXN|RHEA:19505 go.json UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity|UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity|arabinosylindolylacetylinositol synthase activity http://purl.obolibrary.org/obo/GO_0050409 GO:0050406 biolink:MolecularActivity [acetyl-CoA carboxylase]-phosphatase activity Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate. EC:3.1.3.44|MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN|RHEA:17125 go.json acetyl-CoA carboxylase-phosphatase activity|acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050406 GO:0050407 biolink:MolecularActivity [glycogen-synthase-D] phosphatase activity Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate. EC:3.1.3.42|MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN go.json Mg2+ dependent glycogen synthase phosphatase activity|UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity|UDP-glycogen glucosyltransferase phosphatase activity|UDPglucose-glycogen glucosyltransferase phosphatase activity|UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity|glycogen glucosyltransferase phosphatase activity|glycogen synthase D phosphatase activity|glycogen synthase phosphatase activity|glycogen synthetase phosphatase activity|glycogen-synthase-D phosphatase activity|phosphatase type 2oC|uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity http://purl.obolibrary.org/obo/GO_0050407 GO:0050411 biolink:MolecularActivity obsolete agaritine gamma-glutamyltransferase activity OBSOLETE. Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor. go.json (gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity|(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity|agaritine g-glutamyltransferase activity True http://purl.obolibrary.org/obo/GO_0050411 GO:0050412 biolink:MolecularActivity cinnamate beta-D-glucosyltransferase activity Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP. EC:2.4.1.177|KEGG_REACTION:R02256|MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN|RHEA:13437 go.json UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity|UDPG:t-cinnamate glucosyltransferase activity|UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity|cinnamate b-D-glucosyltransferase activity|cinnamate glucosyltransferase activity|uridine diphosphoglucose-cinnamate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050412 GO:0050410 biolink:MolecularActivity 3-oxolaurate decarboxylase activity Catalysis of the reaction: 3-oxolaurate + H+ = 2-undecanone + CO2. EC:4.1.1.56|KEGG_REACTION:R03747|MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN|RHEA:13385 go.json 3-oxododecanoate carboxy-lyase (2-undecanone-forming)|3-oxododecanoate carboxy-lyase activity|beta-ketoacyl decarboxylase activity|beta-ketolaurate decarboxylase activity http://purl.obolibrary.org/obo/GO_0050410 GO:0050415 biolink:MolecularActivity formimidoylglutamase activity Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. EC:3.5.3.8|KEGG_REACTION:R02285|MetaCyc:FORMIMINOGLUTAMASE-RXN|RHEA:22492 go.json N-formimidoyl-L-glutamate formimidoylhydrolase activity|N-formimino-L-glutamate formiminohydrolase activity|N-formiminoglutamate hydrolase activity|formiminoglutamase activity|formiminoglutamate hydrolase activity http://purl.obolibrary.org/obo/GO_0050415 GO:0050416 biolink:MolecularActivity formimidoylglutamate deiminase activity Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3. EC:3.5.3.13|MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN|RHEA:22832 go.json N-formimidoyl-L-glutamate iminohydrolase activity|formiminoglutamate deiminase activity|formiminoglutamic iminohydrolase activity http://purl.obolibrary.org/obo/GO_0050416 GO:0050413 biolink:MolecularActivity D-alanine 2-hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine. EC:2.1.2.7|KEGG_REACTION:R01225|MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN|RHEA:10064 go.json 2-methylserine hydroxymethyltransferase activity|5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity|D-alanine hydroxymethyltransferase activity http://purl.obolibrary.org/obo/GO_0050413 GO:0050414 biolink:MolecularActivity formimidoylaspartate deiminase activity Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3. EC:3.5.3.5|MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN|RHEA:13661 go.json N-formimidoyl-L-aspartate iminohydrolase activity|formiminoaspartate deiminase activity http://purl.obolibrary.org/obo/GO_0050414 GO:0050419 biolink:MolecularActivity hydroxymandelonitrile lyase activity Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate. EC:4.1.2.11|MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN|RHEA:15977 go.json (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)|(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity|hydroxynitrile lyase activity|sorghum hydroxynitrile lyase activity http://purl.obolibrary.org/obo/GO_0050419 GO:0050417 biolink:MolecularActivity glutamin-(asparagin-)ase activity Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate. EC:3.5.1.38|MetaCyc:ASPARAGHYD-RXN|MetaCyc:GLUTAMIN-RXN go.json L-ASNase/L-GLNase activity|L-asparagine/L-glutamine amidohydrolase activity|L-glutamine(L-asparagine) amidohydrolase activity|glutaminase-(asparagin-)ase activity|glutaminase-asparaginase activity http://purl.obolibrary.org/obo/GO_0050417 GO:0050418 biolink:MolecularActivity hydroxylamine reductase activity Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor. EC:1.7.99.1|MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN|RHEA:22052 go.json ammonia:(acceptor) oxidoreductase activity|ammonia:acceptor oxidoreductase activity|hydroxylamine (acceptor) reductase activity http://purl.obolibrary.org/obo/GO_0050418 GO:1990750 biolink:CellularComponent obsolete axon shaft OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites. go.json axonal shaft True http://purl.obolibrary.org/obo/GO_1990750 GO:1990751 biolink:BiologicalProcess Schwann cell chemotaxis The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_1990751 GO:1990752 biolink:CellularComponent microtubule end Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. go.json http://purl.obolibrary.org/obo/GO_1990752 GO:1990753 biolink:CellularComponent equatorial cell cortex The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression. go.json http://purl.obolibrary.org/obo/GO_1990753 GO:1990758 biolink:BiologicalProcess mitotic sister chromatid biorientation The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression. go.json http://purl.obolibrary.org/obo/GO_1990758 GO:1990759 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990759 GO:1990754 biolink:BiologicalProcess obsolete GABAergic neuronal action potential OBSOLETE. An action potential that occurs in a GABAergic neuron. go.json GABAergic neuronal action potential True http://purl.obolibrary.org/obo/GO_1990754 GO:1990755 biolink:BiologicalProcess mitotic spindle microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle. go.json mitotic spindle microtubule depolymerisation http://purl.obolibrary.org/obo/GO_1990755 GO:1990756 biolink:MolecularActivity ubiquitin ligase-substrate adaptor activity The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins. go.json protein binding, bridging involved in substrate recognition for ubiquitination|ubiquitin ligase substrate adaptor http://purl.obolibrary.org/obo/GO_1990756 GO:1990757 biolink:MolecularActivity ubiquitin ligase activator activity Binds to and increases the activity of a ubiquitin ligase. go.json mitotic anaphase-promoting complex activator activity http://purl.obolibrary.org/obo/GO_1990757 GO:1990761 biolink:CellularComponent growth cone lamellipodium A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments. go.json http://purl.obolibrary.org/obo/GO_1990761 GO:1990762 biolink:BiologicalProcess cytoplasmic alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation. go.json http://purl.obolibrary.org/obo/GO_1990762 GO:1990763 biolink:MolecularActivity arrestin family protein binding Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors. go.json http://purl.obolibrary.org/obo/GO_1990763 GO:1990764 biolink:BiologicalProcess myofibroblast contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast. go.json MF contraction|MFB contraction http://purl.obolibrary.org/obo/GO_1990764 GO:1990760 biolink:MolecularActivity osmolarity-sensing monoatomic cation channel activity Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides. go.json osmolarity-sensing cation channel activity http://purl.obolibrary.org/obo/GO_1990760 GO:1990769 biolink:CellularComponent proximal neuron projection The portion of an axon or dendrite that is close to the neuronal cell body. go.json http://purl.obolibrary.org/obo/GO_1990769 GO:1990765 biolink:BiologicalProcess colon smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. go.json http://purl.obolibrary.org/obo/GO_1990765 GO:1990766 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990766 GO:1990767 biolink:BiologicalProcess prostaglandin receptor internalization The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_1990767 GO:1990768 biolink:BiologicalProcess gastric mucosal blood circulation The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. go.json stomach mucosal blood circulation http://purl.obolibrary.org/obo/GO_1990768 GO:1990772 biolink:BiologicalProcess substance P secretion The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity. go.json http://purl.obolibrary.org/obo/GO_1990772 GO:1990773 biolink:BiologicalProcess matrix metallopeptidase secretion The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins. go.json MMP secretion|matrix metalloproteinase secretion http://purl.obolibrary.org/obo/GO_1990773 GO:1990774 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990774 GO:1990775 biolink:BiologicalProcess endothelin production The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. go.json EDN1 production|EDN2 production|EDN3 production|endothelin secretion|endothelin-1 secretion|endothelin-2 production|endothelin-3 production http://purl.obolibrary.org/obo/GO_1990775 gocheck_do_not_annotate GO:1990770 biolink:BiologicalProcess small intestine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. go.json http://purl.obolibrary.org/obo/GO_1990770 GO:1990771 biolink:BiologicalProcess clathrin-dependent extracellular exosome endocytosis The clathrin-mediated endocytosis of an extracellular exosome. go.json clathrin-mediated extracellular exosome endocytosis|exosome related http://purl.obolibrary.org/obo/GO_1990771 GO:1990776 biolink:BiologicalProcess response to angiotensin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. go.json http://purl.obolibrary.org/obo/GO_1990776 GO:1990777 biolink:CellularComponent lipoprotein particle A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_1990777 GO:1990778 biolink:BiologicalProcess protein localization to cell periphery A process in which a protein is transported to, or maintained in, the cell periphery. go.json http://purl.obolibrary.org/obo/GO_1990778 GO:1990779 biolink:CellularComponent glycoprotein Ib-IX-V complex A transmembrane signaling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation. go.json CD42|GPIb-IX-V complex|GPIb-V-IX complex http://purl.obolibrary.org/obo/GO_1990779 GO:1990783 biolink:CellularComponent periphagosomal region of cytoplasm Cytoplasm situated near, or occurring around, a phagosome. go.json http://purl.obolibrary.org/obo/GO_1990783 GO:1990784 biolink:BiologicalProcess response to dsDNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. go.json response to double-stranded DNA http://purl.obolibrary.org/obo/GO_1990784 GO:1990785 biolink:BiologicalProcess response to water-immersion restraint stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile. go.json response to immobilization stress combined with water immersion http://purl.obolibrary.org/obo/GO_1990785 GO:1990786 biolink:BiologicalProcess cellular response to dsDNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. go.json http://purl.obolibrary.org/obo/GO_1990786 GO:1990780 biolink:CellularComponent cytoplasmic side of dendritic spine plasma membrane The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine. go.json http://purl.obolibrary.org/obo/GO_1990780 GO:1990781 biolink:BiologicalProcess response to immobilization stress combined with electrical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile. go.json http://purl.obolibrary.org/obo/GO_1990781 GO:1990782 biolink:MolecularActivity protein tyrosine kinase binding Binding to protein tyrosine kinase. go.json tyrosine kinase binding http://purl.obolibrary.org/obo/GO_1990782 GO:1990787 biolink:BiologicalProcess negative regulation of hh target transcription factor activity Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling. go.json negative regulation of hedgehog target transcription factor http://purl.obolibrary.org/obo/GO_1990787 gocheck_do_not_annotate GO:1990788 biolink:CellularComponent GLI-SUFU complex A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins. go.json http://purl.obolibrary.org/obo/GO_1990788 GO:1990789 biolink:BiologicalProcess thyroid gland epithelial cell proliferation The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population. go.json Hurthle cell proliferation|thyroid follicular cell proliferation http://purl.obolibrary.org/obo/GO_1990789 GO:1990718 biolink:CellularComponent axonemal central pair projection Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules. go.json http://purl.obolibrary.org/obo/GO_1990718 GO:1990719 biolink:CellularComponent C1 axonemal microtubule One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections. go.json C1 tubule http://purl.obolibrary.org/obo/GO_1990719 GO:1990714 biolink:MolecularActivity hydroxyproline O-galactosyltransferase activity Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone. go.json HPGT http://purl.obolibrary.org/obo/GO_1990714 GO:1990715 biolink:MolecularActivity mRNA CDS binding Binding to an mRNA molecule coding sequence (CDS). go.json mRNA coding region binding|mRNA coding sequence binding http://purl.obolibrary.org/obo/GO_1990715 GO:1990716 biolink:CellularComponent axonemal central apparatus Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules. go.json http://purl.obolibrary.org/obo/GO_1990716 GO:1990717 biolink:CellularComponent axonemal central bridge Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules. go.json http://purl.obolibrary.org/obo/GO_1990717 GO:1990710 biolink:CellularComponent MutS complex A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations. go.json MutS mismatch repair complex http://purl.obolibrary.org/obo/GO_1990710 GO:1990711 biolink:CellularComponent beta-catenin-ICAT complex Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex. go.json CTNNB1-CTNNBIP1 complex http://purl.obolibrary.org/obo/GO_1990711 GO:1990712 biolink:CellularComponent HFE-transferrin receptor complex A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. go.json http://purl.obolibrary.org/obo/GO_1990712 GO:1990713 biolink:CellularComponent survivin complex A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC). go.json Baculoviral IAP repeat-containing protein 5 complex|survivin homodimer complex http://purl.obolibrary.org/obo/GO_1990713 GO:1990720 biolink:CellularComponent C2 axonemal microtubule One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections. go.json C2 tubule http://purl.obolibrary.org/obo/GO_1990720 GO:1990729 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990729 GO:1990725 biolink:MolecularActivity cord factor receptor activity Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity. Wikipedia:Cord_factor go.json TMD receptor activity|trehalose 6,6'-dimycolate receptor activity http://purl.obolibrary.org/obo/GO_1990725 GO:1990726 biolink:CellularComponent Lsm1-7-Pat1 complex A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway. go.json http://purl.obolibrary.org/obo/GO_1990726 GO:1990727 biolink:CellularComponent tubulin folding cofactor complex A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur. go.json http://purl.obolibrary.org/obo/GO_1990727 GO:1990728 biolink:CellularComponent mitotic spindle assembly checkpoint MAD1-MAD2 complex A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. go.json MAD1-MAD2 complex http://purl.obolibrary.org/obo/GO_1990728 GO:1990721 biolink:CellularComponent obsolete prostatic acid phosphatase complex OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP. go.json ACPP homodimer complex|PAP complex|prostatic acid phosphatase complex True http://purl.obolibrary.org/obo/GO_1990721 GO:1990722 biolink:CellularComponent DAPK1-calmodulin complex A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding. go.json death-associated protein kinase 1 - calmodulin complex http://purl.obolibrary.org/obo/GO_1990722 GO:1990723 biolink:CellularComponent cytoplasmic periphery of the nuclear pore complex Cytoplasm situated in close proximity to a nuclear pore complex. go.json associated with the nuclear pore http://purl.obolibrary.org/obo/GO_1990723 GO:1990724 biolink:CellularComponent galectin complex A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes. go.json galectin-1 complex|galectin-2 complex http://purl.obolibrary.org/obo/GO_1990724 GO:1990730 biolink:CellularComponent VCP-NSFL1C complex A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. go.json p97-p47 complex http://purl.obolibrary.org/obo/GO_1990730 GO:1990731 biolink:BiologicalProcess obsolete UV-damage excision repair, DNA incision OBSOLETE. A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). go.json DNA incision involved in AER|DNA incision involved in UV-damage excision repair|DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair|DNA incision involved in UVDE-dependent excision repair|DNA incision involved in UVER|DNA incision involved in alternative excision repair|UV-damaged DNA endonuclease-dependent excision repair, DNA incision|UVDE-dependent excision repair, DNA incision|alternative excision repair, DNA incision|nucleic acid cleavage involved in UV-damage excision repair True http://purl.obolibrary.org/obo/GO_1990731 GO:1990736 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell. go.json regulation of vascular smooth muscle cell membrane depolarization http://purl.obolibrary.org/obo/GO_1990736 GO:1990737 biolink:BiologicalProcess response to manganese-induced endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus. go.json manganese-induced ER stress response|response to Mn-induced ER stress|response to manganese-induced ER stress http://purl.obolibrary.org/obo/GO_1990737 GO:1990738 biolink:MolecularActivity pseudouridine 5'-phosphatase activity Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate. EC:3.1.3.96|RHEA:10944 go.json http://purl.obolibrary.org/obo/GO_1990738 GO:1990739 biolink:BiologicalProcess granulosa cell proliferation The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. go.json http://purl.obolibrary.org/obo/GO_1990739 GO:1990732 biolink:CellularComponent pyrenoid A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation. Wikipedia:Pyrenoid go.json http://purl.obolibrary.org/obo/GO_1990732 GO:1990733 biolink:CellularComponent titin-telethonin complex A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils. go.json Titin-Tcap complex http://purl.obolibrary.org/obo/GO_1990733 GO:1990734 biolink:BiologicalProcess astral microtubule anchoring at mitotic spindle pole body Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. go.json http://purl.obolibrary.org/obo/GO_1990734 GO:1990735 biolink:BiologicalProcess gamma-tubulin complex localization to mitotic spindle pole body Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body. go.json establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body|gamma-tubulin complex localisation to mitotic spindle pole body|gamma-tubulin complex localization to mitotic SPB http://purl.obolibrary.org/obo/GO_1990735 GO:1990740 biolink:MolecularActivity obsolete non-selective anion channel activity OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient. go.json nonselective anion channel activity True http://purl.obolibrary.org/obo/GO_1990740 GO:1990741 biolink:MolecularActivity obsolete non-selective cation channel activity OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient. go.json nonselective cation channel activity True http://purl.obolibrary.org/obo/GO_1990741 GO:1990742 biolink:CellularComponent microvesicle An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm. go.json ectosome|extracellular microvesicle|shedding vesicle http://purl.obolibrary.org/obo/GO_1990742 GO:1990747 biolink:BiologicalProcess pancreatic trypsinogen secretion The regulated release of trypsinogen from the cells of the exocrine pancreas. go.json pancreatic trypsinogen release http://purl.obolibrary.org/obo/GO_1990747 GO:1990748 biolink:BiologicalProcess cellular detoxification Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. go.json http://purl.obolibrary.org/obo/GO_1990748 GO:1990749 biolink:MolecularActivity polynucleotide adenylyltransferase activator activity Increases the activity of the enzyme polynucleotide adenylyltransferase. go.json http://purl.obolibrary.org/obo/GO_1990749 GO:1990743 biolink:BiologicalProcess protein sialylation A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein. go.json http://purl.obolibrary.org/obo/GO_1990743 gocheck_do_not_annotate GO:1990744 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990744 GO:1990745 biolink:CellularComponent EARP complex A quatrefoil tethering complex required for endocytic recycling. go.json http://purl.obolibrary.org/obo/GO_1990745 GO:1990746 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990746 GO:0098565 biolink:CellularComponent lumenal side of endosome membrane The side (leaflet) of the endosome membrane that faces the lumen. go.json internal leaflet of endosome membrane|internal side of endosome membrane http://purl.obolibrary.org/obo/GO_0098565 GO:0001653 biolink:MolecularActivity peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity. go.json endogenous peptide receptor activity|exogenous peptide receptor activity http://purl.obolibrary.org/obo/GO_0001653 GO:0001654 biolink:BiologicalProcess eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. Wikipedia:Eye_development go.json http://purl.obolibrary.org/obo/GO_0001654 GO:0098566 biolink:CellularComponent transport vesicle lumen The volume enclosed within the membrane of a transport vesicle. go.json http://purl.obolibrary.org/obo/GO_0098566 GO:0098563 biolink:CellularComponent obsolete intrinsic component of synaptic vesicle membrane OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json True http://purl.obolibrary.org/obo/GO_0098563 GO:0001655 biolink:BiologicalProcess urogenital system development The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0001655 GO:0001656 biolink:BiologicalProcess metanephros development The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0001656 GO:0098564 biolink:CellularComponent trans-Golgi network transport vesicle lumen The volume enclosed within the membrane of a trans-Golgi network transport vesicle. go.json http://purl.obolibrary.org/obo/GO_0098564 GO:0098561 biolink:CellularComponent methyl accepting chemotaxis protein complex A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus. go.json http://purl.obolibrary.org/obo/GO_0098561 GO:0001650 biolink:CellularComponent fibrillar center A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. go.json fibrillar centre http://purl.obolibrary.org/obo/GO_0001650 GO:0098562 biolink:CellularComponent cytoplasmic side of membrane The side of a membrane that faces the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0098562 GO:0001651 biolink:CellularComponent dense fibrillar component A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins. NIF_Subcellular:sao1841764412 go.json pars fibrosa http://purl.obolibrary.org/obo/GO_0001651 GO:0001652 biolink:CellularComponent granular component A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm. NIF_Subcellular:sao1217793903 go.json pars granulosa http://purl.obolibrary.org/obo/GO_0001652 GO:0098560 biolink:CellularComponent cytoplasmic side of late endosome membrane The side (leaflet) of the late endosome membrane that faces the cytoplasm. go.json external leaflet of late endosome membrane|external side of late endosome membrane http://purl.obolibrary.org/obo/GO_0098560 GO:1902137 biolink:BiologicalProcess (-)-secoisolariciresinol catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-secoisolariciresinol. go.json (-)-secoisolariciresinol breakdown|(-)-secoisolariciresinol catabolism|(-)-secoisolariciresinol degradation http://purl.obolibrary.org/obo/GO_1902137 GO:1902138 biolink:BiologicalProcess (-)-secoisolariciresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-secoisolariciresinol. go.json (-)-secoisolariciresinol anabolism|(-)-secoisolariciresinol biosynthesis|(-)-secoisolariciresinol formation|(-)-secoisolariciresinol synthesis http://purl.obolibrary.org/obo/GO_1902138 GO:1902135 biolink:BiologicalProcess (+)-secoisolariciresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-secoisolariciresinol. go.json (+)-secoisolariciresinol anabolism|(+)-secoisolariciresinol biosynthesis|(+)-secoisolariciresinol formation|(+)-secoisolariciresinol synthesis http://purl.obolibrary.org/obo/GO_1902135 GO:1902136 biolink:BiologicalProcess (-)-secoisolariciresinol metabolic process The chemical reactions and pathways involving (-)-secoisolariciresinol. go.json (-)-secoisolariciresinol metabolism http://purl.obolibrary.org/obo/GO_1902136 GO:1902133 biolink:BiologicalProcess (+)-secoisolariciresinol metabolic process The chemical reactions and pathways involving (+)-secoisolariciresinol. go.json (+)-secoisolariciresinol metabolism http://purl.obolibrary.org/obo/GO_1902133 GO:1902134 biolink:BiologicalProcess (+)-secoisolariciresinol catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-secoisolariciresinol. go.json (+)-secoisolariciresinol breakdown|(+)-secoisolariciresinol catabolism|(+)-secoisolariciresinol degradation http://purl.obolibrary.org/obo/GO_1902134 GO:1902140 biolink:BiologicalProcess response to inositol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus. go.json http://purl.obolibrary.org/obo/GO_1902140 GO:1902141 biolink:BiologicalProcess cellular response to inositol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus. go.json http://purl.obolibrary.org/obo/GO_1902141 GO:0001657 biolink:BiologicalProcess ureteric bud development The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0001657 GO:0098569 biolink:CellularComponent internal side of mycolate outer membrane The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. go.json http://purl.obolibrary.org/obo/GO_0098569 GO:0001658 biolink:BiologicalProcess branching involved in ureteric bud morphogenesis The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. go.json ureteric bud branching http://purl.obolibrary.org/obo/GO_0001658 GO:0098567 biolink:CellularComponent periplasmic side of plasma membrane The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface. go.json http://purl.obolibrary.org/obo/GO_0098567 GO:0001659 biolink:BiologicalProcess temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature. Wikipedia:Thermoregulation go.json thermoregulation http://purl.obolibrary.org/obo/GO_0001659 GO:0098568 biolink:CellularComponent external side of mycolate outer membrane The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface. go.json http://purl.obolibrary.org/obo/GO_0098568 GO:0001664 biolink:MolecularActivity G protein-coupled receptor binding Binding to a G protein-coupled receptor. Reactome:R-HSA-500717 go.json G protein coupled receptor binding|G protein coupled receptor ligand|G-protein coupled receptor binding|G-protein-coupled receptor ligand http://purl.obolibrary.org/obo/GO_0001664 GO:0098576 biolink:CellularComponent lumenal side of membrane Any side (leaflet) of a membrane that faces the lumen of an organelle. go.json http://purl.obolibrary.org/obo/GO_0098576 GO:0001665 biolink:MolecularActivity alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. EC:2.4.3.3|MetaCyc:2.4.99.3-RXN|RHEA:11136|Reactome:R-HSA-4084980|Reactome:R-HSA-9603991 go.json GalNAc alpha-2,6-sialyltransferase I activity http://purl.obolibrary.org/obo/GO_0001665 GO:0098577 biolink:CellularComponent inactive sex chromosome A sex chromosome that has been inactivated. go.json inactivated sex chromosome http://purl.obolibrary.org/obo/GO_0098577 GO:0001666 biolink:BiologicalProcess response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. go.json response to hypoxic stress|response to intermittent hypoxia|response to lowered oxygen tension|response to sustained hypoxia http://purl.obolibrary.org/obo/GO_0001666 GO:0098574 biolink:CellularComponent cytoplasmic side of lysosomal membrane The side (leaflet) of the lysosomal membrane that faces the cytoplasm. go.json external leaflet of lysosomal membrane|external side of lysosomal membrane http://purl.obolibrary.org/obo/GO_0098574 GO:0001667 biolink:BiologicalProcess ameboidal-type cell migration Cell migration that is accomplished by extension and retraction of a pseudopodium. go.json ameboid cell migration|amoeboid cell migration|amoeboidal cell migration http://purl.obolibrary.org/obo/GO_0001667 GO:0098575 biolink:CellularComponent lumenal side of lysosomal membrane The side (leaflet) of the lysosomal membrane that faces the lumen. go.json internal leaflet of lysosomal membrane|internal side of lysosomal membrane http://purl.obolibrary.org/obo/GO_0098575 GO:0098572 biolink:CellularComponent stromal side of plastid thylakoid membrane The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface. go.json http://purl.obolibrary.org/obo/GO_0098572 GO:0001660 biolink:BiologicalProcess fever generation The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. Wikipedia:Fever go.json pyrexia http://purl.obolibrary.org/obo/GO_0001660 GO:0098573 biolink:CellularComponent obsolete intrinsic component of mitochondrial membrane OBSOLETE. The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to mitochondrial membrane True http://purl.obolibrary.org/obo/GO_0098573 GO:0001661 biolink:BiologicalProcess conditioned taste aversion A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus. Wikipedia:Conditioned_taste_aversion|Wikipedia:Taste_aversion go.json http://purl.obolibrary.org/obo/GO_0001661 GO:0001662 biolink:BiologicalProcess behavioral fear response An acute behavioral change resulting from a perceived external threat. go.json behavioural fear response http://purl.obolibrary.org/obo/GO_0001662 GO:0098570 biolink:CellularComponent stromal side of plastid inner membrane The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface. go.json http://purl.obolibrary.org/obo/GO_0098570 GO:0098571 biolink:CellularComponent lumenal side of plastid thylakoid membrane The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface. go.json http://purl.obolibrary.org/obo/GO_0098571 GO:0001663 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001663 GO:1902148 biolink:BiologicalProcess positive regulation of response to cytokinesis checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to cytokinesis checkpoint signaling. go.json activation of cytokinesis checkpoint effector process|activation of response to cytokinesis checkpoint signaling|activation of response to signal involved in cytokinesis checkpoint|positive regulation of cytokinesis checkpoint effector process|positive regulation of response to signal involved in cytokinesis checkpoint|up regulation of cytokinesis checkpoint effector process|up regulation of response to cytokinesis checkpoint signaling|up regulation of response to signal involved in cytokinesis checkpoint|up-regulation of cytokinesis checkpoint effector process|up-regulation of response to cytokinesis checkpoint signaling|up-regulation of response to signal involved in cytokinesis checkpoint|upregulation of cytokinesis checkpoint effector process|upregulation of response to cytokinesis checkpoint signaling|upregulation of response to signal involved in cytokinesis checkpoint http://purl.obolibrary.org/obo/GO_1902148 GO:1902149 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902149 GO:1902146 biolink:BiologicalProcess positive regulation of response to cell cycle checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to cell cycle checkpoint signaling. go.json activation of G1/S transition checkpoint effector process|activation of G2/M transition checkpoint effector process|activation of cell cycle checkpoint effector process|activation of response to G1/S transition checkpoint signaling|activation of response to G2/M transition checkpoint signaling|activation of response to cell cycle checkpoint signaling|activation of response to signal involved in G1/S transition checkpoint|activation of response to signal involved in G2/M transition checkpoint|activation of response to signal involved in cell cycle checkpoint|positive regulation of G1/S transition checkpoint effector process|positive regulation of G2/M transition checkpoint effector process|positive regulation of cell cycle checkpoint effector process|positive regulation of response to G1/S transition checkpoint signaling|positive regulation of response to G2/M transition checkpoint signaling|positive regulation of response to signal involved in G1/S transition checkpoint|positive regulation of response to signal involved in G2/M transition checkpoint|positive regulation of response to signal involved in cell cycle checkpoint|up regulation of G1/S transition checkpoint effector process|up regulation of G2/M transition checkpoint effector process|up regulation of cell cycle checkpoint effector process|up regulation of response to G1/S transition checkpoint signaling|up regulation of response to G2/M transition checkpoint signaling|up regulation of response to cell cycle checkpoint signaling|up regulation of response to signal involved in G1/S transition checkpoint|up regulation of response to signal involved in G2/M transition checkpoint|up regulation of response to signal involved in cell cycle checkpoint|up-regulation of G1/S transition checkpoint effector process|up-regulation of G2/M transition checkpoint effector process|up-regulation of cell cycle checkpoint effector process|up-regulation of response to G1/S transition checkpoint signaling|up-regulation of response to G2/M transition checkpoint signaling|up-regulation of response to cell cycle checkpoint signaling|up-regulation of response to signal involved in G1/S transition checkpoint|up-regulation of response to signal involved in G2/M transition checkpoint|up-regulation of response to signal involved in cell cycle checkpoint|upregulation of G1/S transition checkpoint effector process|upregulation of G2/M transition checkpoint effector process|upregulation of cell cycle checkpoint effector process|upregulation of response to G1/S transition checkpoint signaling|upregulation of response to G2/M transition checkpoint signaling|upregulation of response to cell cycle checkpoint signaling|upregulation of response to signal involved in G1/S transition checkpoint|upregulation of response to signal involved in G2/M transition checkpoint|upregulation of response to signal involved in cell cycle checkpoint http://purl.obolibrary.org/obo/GO_1902146 GO:1902147 biolink:BiologicalProcess regulation of response to cytokinesis checkpoint signaling Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling. go.json regulation of cytokinesis checkpoint effector process|regulation of response to signal involved in cytokinesis checkpoint http://purl.obolibrary.org/obo/GO_1902147 GO:1902145 biolink:BiologicalProcess regulation of response to cell cycle checkpoint signaling Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling. go.json regulation of G1/S transition checkpoint effector process|regulation of G2/M transition checkpoint effector process|regulation of cell cycle checkpoint effector process|regulation of response to G1/S transition checkpoint signaling|regulation of response to G2/M transition checkpoint signaling|regulation of response to signal involved in G1/S transition checkpoint|regulation of response to signal involved in G2/M transition checkpoint|regulation of response to signal involved in cell cycle checkpoint http://purl.obolibrary.org/obo/GO_1902145 GO:1902153 biolink:BiologicalProcess regulation of response to DNA damage checkpoint signaling Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling. go.json regulation of DNA damage checkpoint effector process|regulation of response to signal involved in DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1902153 GO:1902154 biolink:BiologicalProcess positive regulation of response to DNA damage checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling. go.json activation of DNA damage checkpoint effector process|activation of response to DNA damage checkpoint signaling|activation of response to signal involved in DNA damage checkpoint|positive regulation of DNA damage checkpoint effector process|positive regulation of response to signal involved in DNA damage checkpoint|up regulation of DNA damage checkpoint effector process|up regulation of response to DNA damage checkpoint signaling|up regulation of response to signal involved in DNA damage checkpoint|up-regulation of DNA damage checkpoint effector process|up-regulation of response to DNA damage checkpoint signaling|up-regulation of response to signal involved in DNA damage checkpoint|upregulation of DNA damage checkpoint effector process|upregulation of response to DNA damage checkpoint signaling|upregulation of response to signal involved in DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1902154 GO:1902151 biolink:BiologicalProcess regulation of response to DNA integrity checkpoint signaling Any process that modulates the frequency, rate or extent of response to DNA integrity checkpoint signaling. go.json regulation of DNA integrity checkpoint effector process|regulation of response to signal involved in DNA integrity checkpoint http://purl.obolibrary.org/obo/GO_1902151 GO:1902152 biolink:BiologicalProcess positive regulation of response to DNA integrity checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling. go.json activation of DNA integrity checkpoint effector process|activation of response to DNA integrity checkpoint signaling|activation of response to signal involved in DNA integrity checkpoint|positive regulation of DNA integrity checkpoint effector process|positive regulation of response to signal involved in DNA integrity checkpoint|up regulation of DNA integrity checkpoint effector process|up regulation of response to DNA integrity checkpoint signaling|up regulation of response to signal involved in DNA integrity checkpoint|up-regulation of DNA integrity checkpoint effector process|up-regulation of response to DNA integrity checkpoint signaling|up-regulation of response to signal involved in DNA integrity checkpoint|upregulation of DNA integrity checkpoint effector process|upregulation of response to DNA integrity checkpoint signaling|upregulation of response to signal involved in DNA integrity checkpoint http://purl.obolibrary.org/obo/GO_1902152 GO:1902150 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902150 GO:0001668 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001668 GO:0001669 biolink:CellularComponent acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. Wikipedia:Acrosome go.json acrosomal granule|acrosome http://purl.obolibrary.org/obo/GO_0001669 GO:0098578 biolink:CellularComponent condensed chromatin of inactivated sex chromosome A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation. go.json http://purl.obolibrary.org/obo/GO_0098578 GO:0098579 biolink:CellularComponent active sex chromosome A sex chromosome that has not been inactivated. go.json http://purl.obolibrary.org/obo/GO_0098579 GO:0098543 biolink:BiologicalProcess detection of other organism The series of events in which a stimulus from another organism is received and converted into a molecular signal. go.json recognition of other organism during symbiotic interaction|recognition of other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0098543 GO:0001631 biolink:MolecularActivity cysteinyl leukotriene receptor activity Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. go.json CysLT receptor http://purl.obolibrary.org/obo/GO_0001631 GO:0001632 biolink:MolecularActivity leukotriene B4 receptor activity Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. go.json BLT receptor http://purl.obolibrary.org/obo/GO_0001632 GO:0098544 biolink:BiologicalProcess maintenance of protein complex location Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away. go.json http://purl.obolibrary.org/obo/GO_0098544 GO:0098541 biolink:CellularComponent cytoplasmic side of trans-Golgi network transport vesicle membrane The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm. go.json external side of trans-Golgi network transport vesicle membrane http://purl.obolibrary.org/obo/GO_0098541 GO:0001633 biolink:MolecularActivity obsolete secretin-like receptor activity OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor. go.json class B G protein coupled receptor|class B G-protein coupled receptor|class B GPCR|class B orphan receptor activity|secretin-like receptor activity True http://purl.obolibrary.org/obo/GO_0001633 GO:0001634 biolink:MolecularActivity pituitary adenylate cyclase-activating polypeptide receptor activity A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. go.json PACAP receptor|pituitary adenylate cyclase activating polypeptide receptor|pituitary adenylate cyclase activating protein receptor activity|pituitary adenylate cyclase-activating peptide receptor activity|pituitary adenylyl cyclase activating protein receptor activity http://purl.obolibrary.org/obo/GO_0001634 GO:0098542 biolink:BiologicalProcess defense response to other organism Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. go.json defence response incompatible interaction|defence response to pathogen, incompatible interaction|defense response, incompatible interaction|resistance response to pathogen http://purl.obolibrary.org/obo/GO_0098542 goslim_generic|prokaryote_subset GO:0098540 biolink:CellularComponent lumenal side of trans-Golgi network transport vesicle membrane The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen. go.json internal side of trans-Golgi network transport vesicle membrane http://purl.obolibrary.org/obo/GO_0098540 GO:0001630 biolink:MolecularActivity obsolete GP40-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json GP40-like receptor activity True http://purl.obolibrary.org/obo/GO_0001630 GO:1902159 biolink:BiologicalProcess regulation of cyclic nucleotide-gated ion channel activity Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. go.json regulation of cyclic nucleotide activated ion channel activity|regulation of cyclic nucleotide gated ion channel activity|regulation of cyclic nucleotide-activated ion channel activity http://purl.obolibrary.org/obo/GO_1902159 gocheck_do_not_annotate GO:1902157 biolink:BiologicalProcess regulation of response to G2 DNA damage checkpoint signaling Any process that modulates the frequency, rate or extent of response to G2 DNA damage checkpoint signaling. go.json regulation of G2/M transition DNA damage checkpoint effector process|regulation of response to signal involved in G2/M transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1902157 GO:1902158 biolink:BiologicalProcess positive regulation of response to G2 DNA damage checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling. go.json activation of G2/M transition DNA damage checkpoint effector process|activation of response to G2 DNA damage checkpoint signaling|activation of response to signal involved in G2/M transition DNA damage checkpoint|positive regulation of G2/M transition DNA damage checkpoint effector process|positive regulation of response to signal involved in G2/M transition DNA damage checkpoint|up regulation of G2/M transition DNA damage checkpoint effector process|up regulation of response to G2 DNA damage checkpoint signaling|up regulation of response to signal involved in G2/M transition DNA damage checkpoint|up-regulation of G2/M transition DNA damage checkpoint effector process|up-regulation of response to G2 DNA damage checkpoint signaling|up-regulation of response to signal involved in G2/M transition DNA damage checkpoint|upregulation of G2/M transition DNA damage checkpoint effector process|upregulation of response to G2 DNA damage checkpoint signaling|upregulation of response to signal involved in G2/M transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1902158 GO:1902155 biolink:BiologicalProcess regulation of response to G1 DNA damage checkpoint signaling Any process that modulates the frequency, rate or extent of response to G1 DNA damage checkpoint signaling. go.json regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process|regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1902155 GO:1902156 biolink:BiologicalProcess positive regulation of response to G1 DNA damage checkpoint signaling Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling. go.json activation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process|activation of response to G1 DNA damage checkpoint signaling|activation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|activation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process|positive regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|positive regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint|up regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process|up regulation of response to G1 DNA damage checkpoint signaling|up regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|up regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint|up-regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process|up-regulation of response to G1 DNA damage checkpoint signaling|up-regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint|upregulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process|upregulation of response to G1 DNA damage checkpoint signaling|upregulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|upregulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1902156 GO:1902164 biolink:BiologicalProcess positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Any process that activates or increases the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. go.json activation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|up regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|upregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator http://purl.obolibrary.org/obo/GO_1902164 GO:1902165 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. go.json regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902165 GO:1902162 biolink:BiologicalProcess regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Any process that modulates the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. go.json http://purl.obolibrary.org/obo/GO_1902162 GO:1902163 biolink:BiologicalProcess negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. go.json down regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|downregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|inhibition of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator http://purl.obolibrary.org/obo/GO_1902163 GO:1902160 biolink:BiologicalProcess negative regulation of cyclic nucleotide-gated ion channel activity Any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. go.json down regulation of cyclic nucleotide activated ion channel activity|down regulation of cyclic nucleotide gated ion channel activity|down regulation of cyclic nucleotide-activated ion channel activity|down regulation of cyclic nucleotide-gated ion channel activity|down-regulation of cyclic nucleotide activated ion channel activity|down-regulation of cyclic nucleotide gated ion channel activity|down-regulation of cyclic nucleotide-activated ion channel activity|down-regulation of cyclic nucleotide-gated ion channel activity|downregulation of cyclic nucleotide activated ion channel activity|downregulation of cyclic nucleotide gated ion channel activity|downregulation of cyclic nucleotide-activated ion channel activity|downregulation of cyclic nucleotide-gated ion channel activity|inhibition of cyclic nucleotide activated ion channel activity|inhibition of cyclic nucleotide gated ion channel activity|inhibition of cyclic nucleotide-activated ion channel activity|inhibition of cyclic nucleotide-gated ion channel activity|negative regulation of cyclic nucleotide activated ion channel activity|negative regulation of cyclic nucleotide gated ion channel activity|negative regulation of cyclic nucleotide-activated ion channel activity http://purl.obolibrary.org/obo/GO_1902160 gocheck_do_not_annotate GO:1902161 biolink:BiologicalProcess positive regulation of cyclic nucleotide-gated ion channel activity Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. go.json activation of cyclic nucleotide activated ion channel activity|activation of cyclic nucleotide gated ion channel activity|activation of cyclic nucleotide-activated ion channel activity|activation of cyclic nucleotide-gated ion channel activity|positive regulation of cyclic nucleotide activated ion channel activity|positive regulation of cyclic nucleotide gated ion channel activity|positive regulation of cyclic nucleotide-activated ion channel activity|up regulation of cyclic nucleotide activated ion channel activity|up regulation of cyclic nucleotide gated ion channel activity|up regulation of cyclic nucleotide-activated ion channel activity|up regulation of cyclic nucleotide-gated ion channel activity|up-regulation of cyclic nucleotide activated ion channel activity|up-regulation of cyclic nucleotide gated ion channel activity|up-regulation of cyclic nucleotide-activated ion channel activity|up-regulation of cyclic nucleotide-gated ion channel activity|upregulation of cyclic nucleotide activated ion channel activity|upregulation of cyclic nucleotide gated ion channel activity|upregulation of cyclic nucleotide-activated ion channel activity|upregulation of cyclic nucleotide-gated ion channel activity http://purl.obolibrary.org/obo/GO_1902161 gocheck_do_not_annotate GO:0001639 biolink:MolecularActivity PLC activating G protein-coupled glutamate receptor activity A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. go.json Group I metabotropic glutamate receptor|PLC activating G-protein coupled glutamate receptor activity|PLC activating metabotropic glutamate receptor activity|group I metabotropic glutamate receptor activity|phospholipase C activating metabotropic glutamate receptor activity http://purl.obolibrary.org/obo/GO_0001639 GO:0098549 biolink:CellularComponent somatic ring canal A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects. go.json http://purl.obolibrary.org/obo/GO_0098549 GO:0001635 biolink:MolecularActivity calcitonin gene-related peptide receptor activity Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. Wikipedia:CALCRL go.json CGRP receptor|calcitonin gene-related polypeptide receptor activity http://purl.obolibrary.org/obo/GO_0001635 GO:0098547 biolink:CellularComponent lumenal side of Golgi membrane The side of the Golgi membrane that faces the lumen. go.json http://purl.obolibrary.org/obo/GO_0098547 GO:0001636 biolink:MolecularActivity obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity True http://purl.obolibrary.org/obo/GO_0001636 GO:0098548 biolink:CellularComponent cytoplasmic side of Golgi membrane The side (leaflet) of the Golgi membrane that faces the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0098548 GO:0001637 biolink:MolecularActivity G protein-coupled chemoattractant receptor activity Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein chemoattractant receptor activity|G-protein chemoattractant receptor activity|G-protein coupled chemoattractant receptor activity http://purl.obolibrary.org/obo/GO_0001637 GO:0098545 biolink:BiologicalProcess maintenance of protein complex location in cytoplasm Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0098545 GO:0098546 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098546 GO:0001638 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001638 GO:0001642 biolink:MolecularActivity group III metabotropic glutamate receptor activity A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. go.json http://purl.obolibrary.org/obo/GO_0001642 GO:0098554 biolink:CellularComponent cytoplasmic side of endoplasmic reticulum membrane The side (leaflet) of the plasma membrane that faces the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0098554 GO:0098555 biolink:CellularComponent lumenal side of rough endoplasmic reticulum membrane The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen. go.json http://purl.obolibrary.org/obo/GO_0098555 GO:0001643 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001643 GO:0098552 biolink:CellularComponent side of membrane A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. go.json http://purl.obolibrary.org/obo/GO_0098552 GO:0001644 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001644 GO:0001645 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001645 GO:0098553 biolink:CellularComponent lumenal side of endoplasmic reticulum membrane The side (leaflet) of the plasma membrane that faces the lumen. go.json http://purl.obolibrary.org/obo/GO_0098553 GO:0098550 biolink:CellularComponent lumenal side of early endosome membrane The side (leaflet) of the early endosome membrane that faces the lumen. go.json internal leaflet of early endosome membrane|internal side of early endosome membrane http://purl.obolibrary.org/obo/GO_0098550 GO:0098551 biolink:CellularComponent lumenal side of late endosome membrane The side (leaflet) of the late endosome membrane that faces the lumen. go.json internal leaflet of late endosome membrane|internal side of late endosome membrane http://purl.obolibrary.org/obo/GO_0098551 GO:0001640 biolink:MolecularActivity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. go.json adenylate cyclase inhibiting metabotropic glutamate receptor activity|adenylyl cyclase inhibiting metabotropic glutamate receptor activity http://purl.obolibrary.org/obo/GO_0001640 GO:0001641 biolink:MolecularActivity group II metabotropic glutamate receptor activity A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. go.json http://purl.obolibrary.org/obo/GO_0001641 GO:1902168 biolink:BiologicalProcess response to catechin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus. go.json http://purl.obolibrary.org/obo/GO_1902168 GO:1902169 biolink:BiologicalProcess cellular response to catechin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus. go.json http://purl.obolibrary.org/obo/GO_1902169 GO:1902166 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. go.json down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_1902166 GO:1902167 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. go.json activation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|activation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|up regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|up regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|upregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|upregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator http://purl.obolibrary.org/obo/GO_1902167 GO:1902175 biolink:BiologicalProcess regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. go.json regulation of intrinsic apoptotic signaling pathway in response to oxidative stress http://purl.obolibrary.org/obo/GO_1902175 GO:1902176 biolink:BiologicalProcess negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. go.json down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress|inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress http://purl.obolibrary.org/obo/GO_1902176 GO:1902173 biolink:BiologicalProcess negative regulation of keratinocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process. go.json down regulation of keratinocyte apoptosis|down regulation of keratinocyte apoptotic process|down-regulation of keratinocyte apoptosis|down-regulation of keratinocyte apoptotic process|downregulation of keratinocyte apoptosis|downregulation of keratinocyte apoptotic process|inhibition of keratinocyte apoptosis|inhibition of keratinocyte apoptotic process|negative regulation of keratinocyte apoptosis http://purl.obolibrary.org/obo/GO_1902173 GO:1902174 biolink:BiologicalProcess positive regulation of keratinocyte apoptotic process Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process. go.json activation of keratinocyte apoptosis|activation of keratinocyte apoptotic process|positive regulation of keratinocyte apoptosis|up regulation of keratinocyte apoptosis|up regulation of keratinocyte apoptotic process|up-regulation of keratinocyte apoptosis|up-regulation of keratinocyte apoptotic process|upregulation of keratinocyte apoptosis|upregulation of keratinocyte apoptotic process http://purl.obolibrary.org/obo/GO_1902174 GO:1990707 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990707 GO:1902171 biolink:BiologicalProcess regulation of tocopherol cyclase activity Any process that modulates the frequency, rate or extent of tocopherol cyclase activity. go.json http://purl.obolibrary.org/obo/GO_1902171 gocheck_do_not_annotate GO:1990708 biolink:BiologicalProcess conditioned place preference The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug. go.json http://purl.obolibrary.org/obo/GO_1990708 GO:1902172 biolink:BiologicalProcess regulation of keratinocyte apoptotic process Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process. go.json regulation of keratinocyte apoptosis http://purl.obolibrary.org/obo/GO_1902172 GO:1990709 biolink:BiologicalProcess presynaptic active zone organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone. go.json presynaptic active zone organisation http://purl.obolibrary.org/obo/GO_1990709 GO:1902170 biolink:BiologicalProcess cellular response to reactive nitrogen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. go.json http://purl.obolibrary.org/obo/GO_1902170 GO:1990703 biolink:CellularComponent obsolete integral component of Golgi medial cisterna membrane OBSOLETE. The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral component of medial-Golgi cisterna membrane True http://purl.obolibrary.org/obo/GO_1990703 GO:1990704 biolink:CellularComponent obsolete integral component of Golgi trans cisterna membrane OBSOLETE. The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral component of trans-Golgi cisterna membrane True http://purl.obolibrary.org/obo/GO_1990704 GO:1990705 biolink:BiologicalProcess cholangiocyte proliferation The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. go.json hepatoblast proliferation http://purl.obolibrary.org/obo/GO_1990705 GO:1990706 biolink:CellularComponent MAD1 complex A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). go.json MAD1 homodimer http://purl.obolibrary.org/obo/GO_1990706 GO:0001646 biolink:MolecularActivity cAMP receptor activity Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json 3',5' cAMP receptor activity|3',5'-cAMP receptor activity|adenosine 3',5'-cyclophosphate receptor activity|class E G protein coupled receptor|class E G-protein coupled receptor|class E GPCR|cyclic AMP receptor activity http://purl.obolibrary.org/obo/GO_0001646 GO:0098558 biolink:CellularComponent lumenal side of smooth endoplasmic reticulum membrane The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen. go.json http://purl.obolibrary.org/obo/GO_0098558 GO:0001647 biolink:MolecularActivity G protein-coupled cytokinin receptor activity Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled cytokinin receptor activity|G-protein coupled cytokinin receptor activity|cytokinin receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0001647 GO:1990700 biolink:BiologicalProcess nucleolar chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin. go.json establishment or maintenance of nucleolar chromatin architecture|nucleolar chromatin organisation http://purl.obolibrary.org/obo/GO_1990700 GO:0098559 biolink:CellularComponent cytoplasmic side of early endosome membrane The side (leaflet) of the early endosome membrane that faces the cytoplasm. go.json external leaflet of early endosome membrane|external side of early endosome membrane http://purl.obolibrary.org/obo/GO_0098559 GO:0001648 biolink:MolecularActivity proteinase-activated receptor activity A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. go.json protease-activated receptor activity|proteinase activated receptor activity http://purl.obolibrary.org/obo/GO_0001648 GO:1990701 biolink:CellularComponent obsolete integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane OBSOLETE. The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral component of ER-Golgi intermediate compartment membrane|integral component of ERGIC membrane|integral component of endoplasmic reticulum-Golgi intermediate compartment membrane True http://purl.obolibrary.org/obo/GO_1990701 GO:0098556 biolink:CellularComponent cytoplasmic side of rough endoplasmic reticulum membrane The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0098556 GO:1990702 biolink:CellularComponent obsolete integral component of Golgi cis cisterna membrane OBSOLETE. The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral component of cis-Golgi cisterna membrane True http://purl.obolibrary.org/obo/GO_1990702 GO:0098557 biolink:CellularComponent cytoplasmic side of smooth endoplasmic reticulum membrane The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0098557 GO:0001649 biolink:BiologicalProcess osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. go.json osteoblast cell differentiation http://purl.obolibrary.org/obo/GO_0001649 GO:0001610 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001610 GO:0001611 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001611 GO:0001612 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001612 GO:1902179 biolink:BiologicalProcess verruculogen metabolic process The chemical reactions and pathways involving verruculogen. go.json verruculogen metabolism http://purl.obolibrary.org/obo/GO_1902179 GO:1902177 biolink:BiologicalProcess positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. go.json activation of intrinsic apoptotic signaling pathway in response to oxidative stress|positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress http://purl.obolibrary.org/obo/GO_1902177 GO:1902178 biolink:BiologicalProcess fibroblast growth factor receptor apoptotic signaling pathway An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR). go.json FGF receptor signaling pathway involved in apoptosis|FGF receptor signaling pathway involved in apoptotic cell death|FGF receptor signaling pathway involved in apoptotic process|FGF receptor signaling pathway involved in apoptotic program|FGF receptor signaling pathway involved in apoptotic programmed cell death|FGF receptor signaling pathway involved in programmed cell death by apoptosis|FGF receptor signaling pathway involved in signaling (initiator) caspase activity|FGF receptor signaling pathway involved in type I programmed cell death|FGF receptor signalling pathway involved in apoptosis|FGF receptor signalling pathway involved in apoptotic cell death|FGF receptor signalling pathway involved in apoptotic process|FGF receptor signalling pathway involved in apoptotic program|FGF receptor signalling pathway involved in apoptotic programmed cell death|FGF receptor signalling pathway involved in programmed cell death by apoptosis|FGF receptor signalling pathway involved in signaling (initiator) caspase activity|FGF receptor signalling pathway involved in type I programmed cell death|FGFR signaling pathway involved in apoptosis|FGFR signaling pathway involved in apoptotic cell death|FGFR signaling pathway involved in apoptotic process|FGFR signaling pathway involved in apoptotic program|FGFR signaling pathway involved in apoptotic programmed cell death|FGFR signaling pathway involved in programmed cell death by apoptosis|FGFR signaling pathway involved in signaling (initiator) caspase activity|FGFR signaling pathway involved in type I programmed cell death|fibroblast growth factor receptor signaling pathway involved in apoptosis|fibroblast growth factor receptor signaling pathway involved in apoptotic cell death|fibroblast growth factor receptor signaling pathway involved in apoptotic process|fibroblast growth factor receptor signaling pathway involved in apoptotic program|fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death|fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis|fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity|fibroblast growth factor receptor signaling pathway involved in type I programmed cell death|fibroblast growth factor receptor signalling pathway involved in apoptosis|fibroblast growth factor receptor signalling pathway involved in apoptotic cell death|fibroblast growth factor receptor signalling pathway involved in apoptotic process|fibroblast growth factor receptor signalling pathway involved in apoptotic program|fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death|fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis|fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity|fibroblast growth factor receptor signalling pathway involved in type I programmed cell death http://purl.obolibrary.org/obo/GO_1902178 GO:1902186 biolink:BiologicalProcess obsolete regulation of viral release from host cell OBSOLETE. Any process that modulates the frequency, rate or extent of viral release from host cell. go.json regulation of release of virus from host|regulation of viral exit|regulation of viral release|regulation of viral shedding True http://purl.obolibrary.org/obo/GO_1902186 GO:1902187 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902187 GO:1902184 biolink:BiologicalProcess negative regulation of shoot apical meristem development Any process that stops, prevents or reduces the frequency, rate or extent of shoot apical meristem development. go.json down regulation of SAM development|down regulation of primary shoot meristem development|down regulation of promeristem development|down regulation of shoot apical meristem development|down-regulation of SAM development|down-regulation of primary shoot meristem development|down-regulation of promeristem development|down-regulation of shoot apical meristem development|downregulation of SAM development|downregulation of primary shoot meristem development|downregulation of promeristem development|downregulation of shoot apical meristem development|inhibition of SAM development|inhibition of primary shoot meristem development|inhibition of promeristem development|inhibition of shoot apical meristem development|negative regulation of SAM development|negative regulation of primary shoot meristem development|negative regulation of promeristem development http://purl.obolibrary.org/obo/GO_1902184 GO:1902185 biolink:BiologicalProcess positive regulation of shoot apical meristem development Any process that activates or increases the frequency, rate or extent of shoot apical meristem development. go.json activation of SAM development|activation of primary shoot meristem development|activation of promeristem development|activation of shoot apical meristem development|positive regulation of SAM development|positive regulation of primary shoot meristem development|positive regulation of promeristem development|up regulation of SAM development|up regulation of primary shoot meristem development|up regulation of promeristem development|up regulation of shoot apical meristem development|up-regulation of SAM development|up-regulation of primary shoot meristem development|up-regulation of promeristem development|up-regulation of shoot apical meristem development|upregulation of SAM development|upregulation of primary shoot meristem development|upregulation of promeristem development|upregulation of shoot apical meristem development http://purl.obolibrary.org/obo/GO_1902185 GO:1902182 biolink:BiologicalProcess shoot apical meristem development The process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure. go.json SAM development|primary shoot meristem development|promeristem development http://purl.obolibrary.org/obo/GO_1902182 GO:1902183 biolink:BiologicalProcess regulation of shoot apical meristem development Any process that modulates the frequency, rate or extent of shoot apical meristem development. go.json regulation of SAM development|regulation of primary shoot meristem development|regulation of promeristem development http://purl.obolibrary.org/obo/GO_1902183 GO:1902180 biolink:BiologicalProcess obsolete verruculogen catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of verruculogen. go.json verruculogen breakdown|verruculogen catabolism|verruculogen degradation True http://purl.obolibrary.org/obo/GO_1902180 GO:1902181 biolink:BiologicalProcess verruculogen biosynthetic process The chemical reactions and pathways resulting in the formation of verruculogen. go.json verruculogen anabolism|verruculogen biosynthesis|verruculogen formation|verruculogen synthesis http://purl.obolibrary.org/obo/GO_1902181 GO:0001617 biolink:MolecularActivity obsolete growth hormone secretagogue-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json growth hormone secretagogue-like receptor activity True http://purl.obolibrary.org/obo/GO_0001617 GO:0001618 biolink:MolecularActivity virus receptor activity Combining with a virus component and mediating entry of the virus into the cell. go.json viral receptor activity http://purl.obolibrary.org/obo/GO_0001618 goslim_chembl|goslim_generic GO:0001619 biolink:MolecularActivity obsolete lysosphingolipid and lysophosphatidic acid receptor activity OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. go.json lysosphingolipid and lysophosphatidic acid receptor activity True http://purl.obolibrary.org/obo/GO_0001619 GO:0001613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001613 GO:0001614 biolink:MolecularActivity purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json P2 receptor|purinergic receptor activity|purinoceptor|purinoreceptor http://purl.obolibrary.org/obo/GO_0001614 GO:0001615 biolink:MolecularActivity obsolete thyrotropin releasing hormone and secretagogue-like receptors activity OBSOLETE. (Was not defined before being made obsolete). go.json thyrotropin releasing hormone and secretagogue-like receptors activity True http://purl.obolibrary.org/obo/GO_0001615 GO:0001616 biolink:MolecularActivity growth hormone secretagogue receptor activity Combining with ghrelin to initiate a change in cell activity. go.json ghrelin receptor activity http://purl.obolibrary.org/obo/GO_0001616 GO:0001620 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001620 GO:0001621 biolink:MolecularActivity G protein-coupled ADP receptor activity Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json ADP receptor activity|ADP-activated adenosine receptor activity|ADP-activated nucleotide receptor activity|K101 receptor|platelet ADP receptor activity http://purl.obolibrary.org/obo/GO_0001621 GO:0001622 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001622 GO:0001623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001623 GO:1902188 biolink:BiologicalProcess obsolete positive regulation of viral release from host cell OBSOLETE. Any process that activates or increases the frequency, rate or extent of viral release from host cell. go.json activation of release of virus from host|activation of viral exit|activation of viral release|activation of viral release from host cell|activation of viral shedding|positive regulation of release of virus from host|positive regulation of viral exit|positive regulation of viral release|positive regulation of viral shedding|up regulation of release of virus from host|up regulation of viral exit|up regulation of viral release|up regulation of viral release from host cell|up regulation of viral shedding|up-regulation of release of virus from host|up-regulation of viral exit|up-regulation of viral release|up-regulation of viral release from host cell|up-regulation of viral shedding|upregulation of release of virus from host|upregulation of viral exit|upregulation of viral release|upregulation of viral release from host cell|upregulation of viral shedding True http://purl.obolibrary.org/obo/GO_1902188 GO:1902189 biolink:BiologicalProcess 2-methylbutanoyl-CoA(4-) metabolic process The chemical reactions and pathways involving 2-methylbutanoyl-CoA(4-). go.json 2-methylbutanoyl-CoA(4-) metabolism http://purl.obolibrary.org/obo/GO_1902189 GO:1902197 biolink:BiologicalProcess isovaleryl-CoA(4-) biosynthetic process The chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-). go.json isovaleryl-CoA(4-) anabolism|isovaleryl-CoA(4-) biosynthesis|isovaleryl-CoA(4-) formation|isovaleryl-CoA(4-) synthesis http://purl.obolibrary.org/obo/GO_1902197 GO:1902198 biolink:BiologicalProcess 3-methylbut-2-enoyl-CoA(4-) metabolic process The chemical reactions and pathways involving 3-methylbut-2-enoyl-CoA(4-). go.json 3-methylbut-2-enoyl-CoA(4-) metabolism http://purl.obolibrary.org/obo/GO_1902198 GO:1902195 biolink:BiologicalProcess isovaleryl-CoA(4-) metabolic process The chemical reactions and pathways involving isovaleryl-CoA(4-). go.json isovaleryl-CoA(4-) metabolism http://purl.obolibrary.org/obo/GO_1902195 GO:1902196 biolink:BiologicalProcess isovaleryl-CoA(4-) catabolic process The chemical reactions and pathways resulting in the breakdown of isovaleryl-CoA(4-). go.json isovaleryl-CoA(4-) breakdown|isovaleryl-CoA(4-) catabolism|isovaleryl-CoA(4-) degradation http://purl.obolibrary.org/obo/GO_1902196 GO:1902193 biolink:BiologicalProcess 2-methylbut-2-enoyl-CoA(4-) catabolic process The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-). go.json 2-methylbut-2-enoyl-CoA(4-) breakdown|2-methylbut-2-enoyl-CoA(4-) catabolism|2-methylbut-2-enoyl-CoA(4-) degradation http://purl.obolibrary.org/obo/GO_1902193 GO:1902194 biolink:BiologicalProcess 2-methylbut-2-enoyl-CoA(4-) biosynthetic process The chemical reactions and pathways resulting in the formation of 2-methylbut-2-enoyl-CoA(4-). go.json 2-methylbut-2-enoyl-CoA(4-) anabolism|2-methylbut-2-enoyl-CoA(4-) biosynthesis|2-methylbut-2-enoyl-CoA(4-) formation|2-methylbut-2-enoyl-CoA(4-) synthesis http://purl.obolibrary.org/obo/GO_1902194 GO:1902191 biolink:BiologicalProcess 2-methylbutanoyl-CoA(4-) biosynthetic process The chemical reactions and pathways resulting in the formation of 2-methylbutanoyl-CoA(4-). go.json 2-methylbutanoyl-CoA(4-) anabolism|2-methylbutanoyl-CoA(4-) biosynthesis|2-methylbutanoyl-CoA(4-) formation|2-methylbutanoyl-CoA(4-) synthesis http://purl.obolibrary.org/obo/GO_1902191 GO:1902192 biolink:BiologicalProcess 2-methylbut-2-enoyl-CoA(4-) metabolic process The chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-). go.json 2-methylbut-2-enoyl-CoA(4-) metabolism http://purl.obolibrary.org/obo/GO_1902192 GO:0001628 biolink:MolecularActivity obsolete gastropyloric receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json GPR receptor|gastropyloric receptor activity True http://purl.obolibrary.org/obo/GO_0001628 GO:1902190 biolink:BiologicalProcess 2-methylbutanoyl-CoA(4-) catabolic process The chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-). go.json 2-methylbutanoyl-CoA(4-) breakdown|2-methylbutanoyl-CoA(4-) catabolism|2-methylbutanoyl-CoA(4-) degradation http://purl.obolibrary.org/obo/GO_1902190 GO:0001629 biolink:MolecularActivity obsolete G-protein receptor 45-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json G protein receptor 45-like receptor activity|G-protein receptor 45-like receptor activity|GPR45-like receptor True http://purl.obolibrary.org/obo/GO_0001629 GO:0001624 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001624 GO:0001625 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001625 GO:0001626 biolink:MolecularActivity nociceptin receptor activity Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. go.json OFQ receptor activity|ORPH receptor|X-opioid receptor activity|nociceptin/orphanin-FQ receptor activity|orphanin-FQ receptor activity http://purl.obolibrary.org/obo/GO_0001626 GO:0001627 biolink:MolecularActivity obsolete leucine-rich G-protein receptor-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json LGR-like receptor|leucine-rich G protein receptor-like receptor activity|leucine-rich G-protein receptor-like receptor activity True http://purl.obolibrary.org/obo/GO_0001627 GO:0098587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098587 GO:0098588 biolink:CellularComponent bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle. go.json http://purl.obolibrary.org/obo/GO_0098588 GO:0098585 biolink:CellularComponent host cell synaptic vesicle membrane The lipid bilayer surrounding a host synaptic vesicle. go.json http://purl.obolibrary.org/obo/GO_0098585 GO:0098586 biolink:BiologicalProcess cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. go.json http://purl.obolibrary.org/obo/GO_0098586 GO:0098583 biolink:BiologicalProcess learned vocalization behavior A vocalization behavior that is the result of learning. go.json http://purl.obolibrary.org/obo/GO_0098583 GO:0098584 biolink:CellularComponent host cell synaptic vesicle A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0098584 GO:0098581 biolink:BiologicalProcess detection of external biotic stimulus The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated. go.json detection of exogenous biotic stimulus http://purl.obolibrary.org/obo/GO_0098581 GO:0098582 biolink:BiologicalProcess innate vocalization behavior A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur. go.json http://purl.obolibrary.org/obo/GO_0098582 GO:0098580 biolink:CellularComponent obsolete chromatin of active sex chromosome OBSOLETE. Chromatin that is part of an active sex chromosome. go.json True http://purl.obolibrary.org/obo/GO_0098580 GO:1902199 biolink:BiologicalProcess 3-methylbut-2-enoyl-CoA(4-) catabolic process The chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-). go.json 3-methylbut-2-enoyl-CoA(4-) breakdown|3-methylbut-2-enoyl-CoA(4-) catabolism|3-methylbut-2-enoyl-CoA(4-) degradation http://purl.obolibrary.org/obo/GO_1902199 GO:0098589 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098589 GO:0098598 biolink:BiologicalProcess learned vocalization behavior or vocal learning Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned. go.json http://purl.obolibrary.org/obo/GO_0098598 GO:0098599 biolink:MolecularActivity palmitoyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. Reactome:R-HSA-5690046|Reactome:R-HSA-9027670 go.json http://purl.obolibrary.org/obo/GO_0098599 GO:0098596 biolink:BiologicalProcess imitative learning Learning in which new behaviors are acquired through imitation. Wikipedia:Imitative_learning|Wikipedia:Observational_learning#Observational_learning_compared_to_imitation go.json http://purl.obolibrary.org/obo/GO_0098596 GO:0001600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001600 GO:0098597 biolink:BiologicalProcess observational learning Learning that occurs through observing the behavior of others. Wikipedia:Observational_learning go.json http://purl.obolibrary.org/obo/GO_0098597 GO:0001601 biolink:MolecularActivity peptide YY receptor activity Combining with gut peptide YY to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001601 GO:0098594 biolink:CellularComponent mucin granule A secretory granule that contains mucin. go.json http://purl.obolibrary.org/obo/GO_0098594 GO:0098595 biolink:CellularComponent perivitelline space The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane). go.json http://purl.obolibrary.org/obo/GO_0098595 GO:0098592 biolink:CellularComponent cytoplasmic side of apical plasma membrane The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0098592 GO:0098593 biolink:CellularComponent goblet cell theca A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel. go.json http://purl.obolibrary.org/obo/GO_0098593 GO:0098590 biolink:CellularComponent plasma membrane region A membrane that is a (regional) part of the plasma membrane. go.json region of plasma membrane http://purl.obolibrary.org/obo/GO_0098590 gocheck_do_not_manually_annotate GO:0098591 biolink:CellularComponent external side of apical plasma membrane The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. go.json http://purl.obolibrary.org/obo/GO_0098591 GO:0001606 biolink:MolecularActivity obsolete GPR37/endothelin B-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json GPR37/endothelin B-like receptor activity True http://purl.obolibrary.org/obo/GO_0001606 GO:0001607 biolink:MolecularActivity neuromedin U receptor activity Combining with neuromedin U to initiate a change in cell activity. go.json NMUR activity http://purl.obolibrary.org/obo/GO_0001607 GO:0001608 biolink:MolecularActivity G protein-coupled nucleotide receptor activity Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled nucleotide receptor activity|G-protein coupled nucleotide receptor activity|nucleotide receptor activity, G protein coupled|nucleotide receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0001608 GO:0001609 biolink:MolecularActivity G protein-coupled adenosine receptor activity Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json A1 adenosine receptor activity, G protein coupled|A1 adenosine receptor activity, G-protein coupled|A2A adenosine receptor activity, G protein coupled|A2A adenosine receptor activity, G-protein coupled|A2B adenosine receptor activity, G protein coupled|A2B adenosine receptor activity, G-protein coupled|A3 adenosine receptor activity, G protein coupled|A3 adenosine receptor activity, G-protein coupled|G protein coupled A1 adenosine receptor activity|G protein coupled A2A adenosine receptor activity|G protein coupled A2B adenosine receptor activity|G protein coupled A3 adenosine receptor activity|G protein coupled adenosine receptor activity|G-protein coupled adenosine receptor activity|G-protein-coupled A1 adenosine receptor activity|G-protein-coupled A2A adenosine receptor activity|G-protein-coupled A2B adenosine receptor activity|G-protein-coupled A3 adenosine receptor activity|P1 receptor|adenosine nucleotide receptor|adenosine receptor activity, G protein coupled|adenosine receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0001609 GO:0001602 biolink:MolecularActivity pancreatic polypeptide receptor activity Combining with pancreatic polypeptide PP to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001602 GO:0001603 biolink:MolecularActivity obsolete vasopressin-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json vasopressin-like receptor activity True http://purl.obolibrary.org/obo/GO_0001603 GO:0001604 biolink:MolecularActivity urotensin II receptor activity Combining with urotensin II to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001604 GO:0001605 biolink:MolecularActivity adrenomedullin receptor activity Combining with adrenomedullin to initiate a change in cell activity. go.json G10D receptor http://purl.obolibrary.org/obo/GO_0001605 GO:0050543 biolink:MolecularActivity icosatetraenoic acid binding Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule. go.json eicosatetraenoic acid binding http://purl.obolibrary.org/obo/GO_0050543 GO:0050544 biolink:MolecularActivity arachidonic acid binding Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. go.json arachidonate binding http://purl.obolibrary.org/obo/GO_0050544 GO:0050541 biolink:MolecularActivity beta,beta-carotene-9',10'-dioxygenase activity Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone. go.json b,b-carotene-9',10'-dioxygenase activity http://purl.obolibrary.org/obo/GO_0050541 GO:0050542 biolink:MolecularActivity icosanoid binding Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. go.json eicosanoid binding http://purl.obolibrary.org/obo/GO_0050542 GO:0050547 biolink:MolecularActivity vanillin synthase activity Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin. EC:4.1.2.61|KEGG_REACTION:R05773|MetaCyc:4.1.2.41-RXN|RHEA:18725 go.json 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)|3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming) http://purl.obolibrary.org/obo/GO_0050547 GO:0050548 biolink:MolecularActivity trans-feruloyl-CoA hydratase activity Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA. EC:4.2.1.101|MetaCyc:4.2.1.101-RXN|RHEA:14517 go.json 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)|trans-feruloyl-CoA hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050548 GO:0050545 biolink:MolecularActivity sulfopyruvate decarboxylase activity Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde. EC:4.1.1.79|KEGG_REACTION:R05774|MetaCyc:R231-RXN|RHEA:20948 go.json sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)|sulfopyruvate carboxy-lyase activity|sulphopyruvate decarboxylase activity http://purl.obolibrary.org/obo/GO_0050545 GO:0050546 biolink:MolecularActivity 4-hydroxyphenylpyruvate decarboxylase activity Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2. EC:4.1.1.80|KEGG_REACTION:R03341|MetaCyc:4.1.1.80-RXN|RHEA:18697 go.json 4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)|4-hydroxyphenylpyruvate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0050546 GO:0050549 biolink:MolecularActivity cyclohexyl-isocyanide hydratase activity Catalysis of the reaction: N-cyclohexylformamide + H+ = cyclohexyl isocyanide + H2O. EC:4.2.1.103|KEGG_REACTION:R05771|MetaCyc:4.2.1.103-RXN|RHEA:18197|UM-BBD_reactionID:r1029 go.json N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)|N-cyclohexylformamide hydro-lyase activity|isonitrile hydratase activity http://purl.obolibrary.org/obo/GO_0050549 GO:0050540 biolink:MolecularActivity 2-aminomuconate deaminase activity Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4. EC:3.5.99.5|KEGG_REACTION:R03887|MetaCyc:3.5.99.5-RXN|RHEA:20996 go.json 2-aminomuconate aminohydrolase activity http://purl.obolibrary.org/obo/GO_0050540 GO:0050554 biolink:MolecularActivity abietadiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate. EC:4.2.3.18|KEGG_REACTION:R06301|MetaCyc:4.2.3.18-RXN|RHEA:13873 go.json (+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)|abietadiene cyclase activity|copalyl-diphosphate diphosphate-lyase (cyclizing) http://purl.obolibrary.org/obo/GO_0050554 GO:0050555 biolink:MolecularActivity 2-hydroxypropyl-CoM lyase activity Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane. EC:4.4.1.23|MetaCyc:4.2.99.19-RXN|RHEA:19421|UM-BBD_enzymeID:e0538 go.json (R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)|(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)|2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)|EaCoMT activity|coenzyme M-epoxyalkane ligase activity|epoxyalkane:2-mercaptoethanesulfonate transferase activity|epoxyalkane:CoM transferase activity|epoxyalkane:coenzyme M transferase activity|epoxyalkyl:CoM transferase activity|epoxypropane:coenzyme M transferase activity|epoxypropyl:CoM transferase activity http://purl.obolibrary.org/obo/GO_0050555 GO:0050552 biolink:MolecularActivity (4S)-limonene synthase activity Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate. EC:4.2.3.16|MetaCyc:4.2.3.16-RXN|RHEA:12869 go.json (-)-(4S)-limonene synthase activity|4S-(-)-limonene synthase activity|geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]|geranyldiphosphate diphosphate lyase (limonene forming)|geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming] http://purl.obolibrary.org/obo/GO_0050552 GO:0050553 biolink:MolecularActivity taxadiene synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene. EC:4.2.3.17|KEGG_REACTION:R06305|MetaCyc:4.2.3.17-RXN|RHEA:20912 go.json geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)|geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)|taxa-4(5),11(12)-diene synthase activity http://purl.obolibrary.org/obo/GO_0050553 GO:0050558 biolink:MolecularActivity maltose epimerase activity Catalysis of the reaction: alpha-maltose = beta-maltose. EC:5.1.3.21|KEGG_REACTION:R07319|MetaCyc:5.1.3.21-RXN|RHEA:21228 go.json maltose 1-epimerase activity http://purl.obolibrary.org/obo/GO_0050558 GO:0050559 biolink:MolecularActivity copalyl diphosphate synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate. EC:5.5.1.12|KEGG_REACTION:R06298|MetaCyc:RXN-4861|RHEA:24316 go.json (+)-copalyl-diphosphate lyase (decyclizing)|diterpene cyclase activity http://purl.obolibrary.org/obo/GO_0050559 GO:0050556 biolink:MolecularActivity deacetylisoipecoside synthase activity Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin. EC:4.3.3.3|KEGG_REACTION:R05750|MetaCyc:4.3.3.3-RXN|RHEA:21756 go.json deacetylisoipecoside dopamine-lyase (secologanin-forming)|deacetylisoipecoside dopamine-lyase activity http://purl.obolibrary.org/obo/GO_0050556 GO:0050557 biolink:MolecularActivity deacetylipecoside synthase activity Catalysis of the reaction: deacetylipecoside + H2O = dopamine + secologanin. EC:4.3.3.4|KEGG_REACTION:R05749|MetaCyc:4.3.3.4-RXN|RHEA:12296 go.json deacetylipecoside dopamine-lyase (secologanin-forming)|deacetylipecoside dopamine-lyase activity http://purl.obolibrary.org/obo/GO_0050557 GO:0050550 biolink:MolecularActivity pinene synthase activity Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. EC:4.2.3.14|MetaCyc:RXN-5106|MetaCyc:RXN-5107 go.json (-)-(1S,5S)-pinene synthase activity|beta-geraniolene synthase activity|geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)|geranyldiphosphate diphosphate lyase (pinene forming) http://purl.obolibrary.org/obo/GO_0050550 GO:0050551 biolink:MolecularActivity myrcene synthase activity Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene. EC:4.2.3.15|KEGG_REACTION:R02009|MetaCyc:RXN-5110|RHEA:16965 go.json geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity http://purl.obolibrary.org/obo/GO_0050551 GO:0001598 biolink:MolecularActivity obsolete chemokine receptor-like receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json chemokine receptor-like receptor activity True http://purl.obolibrary.org/obo/GO_0001598 GO:0050565 biolink:MolecularActivity aerobactin synthase activity Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+. RHEA:32167 go.json citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)|citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0050565 GO:0050566 biolink:MolecularActivity asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP. EC:6.3.5.6|MetaCyc:6.3.5.6-RXN|RHEA:14513|Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing) go.json Asp-AdT activity|Asp-tRNA(Asn) amidotransferase activity|Asp-tRNAAsn amidotransferase activity|Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)|asparaginyl-tRNA synthase (glutamine-hydrolysing)|aspartyl-tRNA(Asn) amidotransferase activity|aspartyl-tRNAAsn amidotransferase activity|aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0050566 GO:0001599 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001599 GO:0050563 biolink:MolecularActivity trans-feruloyl-CoA synthase activity Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate. EC:6.2.1.34|MetaCyc:6.2.1.34-RXN|RHEA:19389 go.json ferulate-CoA ligase activity|trans-ferulate:CoASH ligase (ATP-hydrolysing)|trans-feruloyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0050563 GO:0050564 biolink:MolecularActivity N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+. EC:6.3.2.26|KEGG_REACTION:R04870|MetaCyc:6.3.2.26-RXN|RHEA:23196 go.json ACV synthetase activity|L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)|L-alpha-aminoadipyl-cysteinyl-valine synthetase activity|L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity http://purl.obolibrary.org/obo/GO_0050564 GO:0050569 biolink:MolecularActivity glycolaldehyde dehydrogenase activity Catalysis of the reaction: glycolaldehyde + H2O + NAD(+) = glycolate + 2 H+ + NADH. EC:1.2.1.21|KEGG_REACTION:R01333|MetaCyc:GLYCOLALD-DEHYDROG-RXN|RHEA:20001 go.json glycol aldehyde dehydrogenase activity|glycolaldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050569 GO:0001594 biolink:MolecularActivity trace-amine receptor activity Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. go.json http://purl.obolibrary.org/obo/GO_0001594 GO:0001595 biolink:MolecularActivity angiotensin receptor activity Combining with angiotensin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001595 GO:0001596 biolink:MolecularActivity angiotensin type I receptor activity An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. go.json PLC-activating angiotensin receptor activity http://purl.obolibrary.org/obo/GO_0001596 GO:0050567 biolink:MolecularActivity glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. EC:6.3.5.7|MetaCyc:6.3.5.7-RXN|RHEA:17521|Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing) go.json Glu-AdT activity|Glu-tRNA(Gln) amidotransferase activity|Glu-tRNAGln amidotransferase activity|Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)|glutaminyl-tRNA synthase (glutamine-hydrolysing)|glutamyl-tRNA(Gln) amidotransferase activity|glutamyl-tRNAGln amidotransferase activity|glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0050567 GO:0001597 biolink:MolecularActivity obsolete apelin-like receptor OBSOLETE. (Was not defined before being made obsolete). go.json APJ-like receptor|apelin-like receptor True http://purl.obolibrary.org/obo/GO_0001597 GO:0050568 biolink:MolecularActivity protein-glutamine glutaminase activity Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3. EC:3.5.1.44|MetaCyc:CHEBDEAMID-RXN|RHEA:16441 go.json destabilase activity|glutaminyl-peptide glutaminase activity|glutaminylpeptide glutaminase activity|peptidoglutaminase II activity|peptidylglutaminase II|protein-L-glutamine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050568 GO:0001590 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001590 GO:0001591 biolink:MolecularActivity dopamine neurotransmitter receptor activity, coupled via Gi/Go Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. go.json dopamine D2 receptor activity|dopamine D3 receptor activity|dopamine D4 receptor activity http://purl.obolibrary.org/obo/GO_0001591 GO:0001592 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001592 GO:0001593 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001593 GO:0050561 biolink:MolecularActivity glutamate-tRNA(Gln) ligase activity Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. EC:6.1.1.24|MetaCyc:6.1.1.24-RXN|RHEA:18397 go.json L-glutamate:tRNAGlx ligase (AMP-forming)|glutamate-tRNAGln ligase activity|nondiscriminating glutamyl-tRNA synthetase activity http://purl.obolibrary.org/obo/GO_0050561 GO:0050562 biolink:MolecularActivity lysine-tRNA(Pyl) ligase activity Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP. MetaCyc:6.1.1.25-RXN go.json L-lysine:tRNAPyl ligase (AMP-forming)|lysine-tRNAPyl ligase activity http://purl.obolibrary.org/obo/GO_0050562 GO:0050560 biolink:MolecularActivity aspartate-tRNA(Asn) ligase activity Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. EC:6.1.1.23|MetaCyc:6.1.1.23-RXN|RHEA:18349 go.json L-aspartate:tRNAAsx ligase (AMP-forming)|aspartate-tRNAAsn ligase activity|nondiscriminating aspartyl-tRNA synthetase activity http://purl.obolibrary.org/obo/GO_0050560 GO:0050576 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050576 GO:0050577 biolink:MolecularActivity GDP-L-fucose synthase activity Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. EC:1.1.1.271|MetaCyc:1.1.1.271-RXN|RHEA:18885|Reactome:R-HSA-6787642 go.json GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity|GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)|GDP-fucose synthetase activity http://purl.obolibrary.org/obo/GO_0050577 GO:0050574 biolink:MolecularActivity 2-(R)-hydroxypropyl-CoM dehydrogenase activity Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH. EC:1.1.1.268|KEGG_REACTION:R05689|MetaCyc:1.1.1.268-RXN|RHEA:13249|UM-BBD_reactionID:r0852 go.json 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity|2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050574 GO:0050575 biolink:MolecularActivity 2-(S)-hydroxypropyl-CoM dehydrogenase activity Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH. EC:1.1.1.269|KEGG_REACTION:R05690|MetaCyc:1.1.1.269-RXN|RHEA:21052|UM-BBD_reactionID:r0853 go.json 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity|2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050575 GO:0050578 biolink:MolecularActivity (R)-2-hydroxyacid dehydrogenase activity Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+. EC:1.1.1.272|MetaCyc:1.1.1.272-RXN|RHEA:35735 go.json (R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity|(R)-sulfolactate:NAD(P)(+) oxidoreductase activity|(R)-sulfolactate:NAD(P)+ oxidoreductase activity|L-sulfolactate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050578 GO:0050579 biolink:MolecularActivity vellosimine dehydrogenase activity Catalysis of the reaction: 10-deoxysarpagine + NADP+ = H+ + NADPH + vellosimine. EC:1.1.1.273|KEGG_REACTION:R05827|MetaCyc:1.1.1.273-RXN|RHEA:20029 go.json 10-deoxysarpagine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050579 GO:0050572 biolink:MolecularActivity L-idonate 5-dehydrogenase activity Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+. EC:1.1.1.264|MetaCyc:1.1.1.264-RXN go.json L-idonate:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050572 GO:0050573 biolink:MolecularActivity dTDP-4-dehydro-6-deoxyglucose reductase activity Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH. EC:1.1.1.266|KEGG_REACTION:R05687|MetaCyc:1.1.1.266-RXN|RHEA:36583 go.json dTDP-4-keto-6-deoxyglucose reductase activity|dTDP-D-fucose:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050573 GO:0050570 biolink:MolecularActivity 4-hydroxythreonine-4-phosphate dehydrogenase activity Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. EC:1.1.1.262|MetaCyc:RXN-13179|RHEA:32275 go.json L-threonine 4-phosphate dehydrogenase activity|NAD(+)-dependent threonine 4-phosphate dehydrogenase activity|NAD+-dependent threonine 4-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050570 GO:0050571 biolink:MolecularActivity 1,5-anhydro-D-fructose reductase activity Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH. EC:1.1.1.263|KEGG_REACTION:R05682|MetaCyc:1.1.1.263-RXN|RHEA:20665 go.json 1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity|AF reductase activity http://purl.obolibrary.org/obo/GO_0050571 GO:0098521 biolink:CellularComponent inhibitory neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0098521 GO:0050587 biolink:MolecularActivity chlorite O2-lyase activity Catalysis of the reaction: chloride + O2 = chlorite. EC:1.13.11.49|KEGG_REACTION:R05721|MetaCyc:1.13.11.49-RXN|RHEA:21404|UM-BBD_reactionID:r0982 go.json chloride:oxygen oxidoreductase activity|chlorite dismutase activity http://purl.obolibrary.org/obo/GO_0050587 GO:0001576 biolink:BiologicalProcess globoside biosynthetic process The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). go.json globoside anabolism|globoside biosynthesis|globoside formation|globoside synthesis http://purl.obolibrary.org/obo/GO_0001576 GO:0001577 biolink:MolecularActivity obsolete galectin OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars. go.json S-type lectin|galectin True http://purl.obolibrary.org/obo/GO_0001577 GO:0098522 biolink:CellularComponent neuromuscular junction of skeletal muscle fiber A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber. go.json http://purl.obolibrary.org/obo/GO_0098522 GO:0050588 biolink:MolecularActivity apo-beta-carotenoid-14',13'-dioxygenase activity Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal. EC:1.13.11.67|KEGG_REACTION:R08889|MetaCyc:1.13.12.12-RXN|RHEA:26023 go.json 8'-apo-beta-carotenol:O2 oxidoreductase activity|apo-b-carotenoid-14',13'-dioxygenase activity http://purl.obolibrary.org/obo/GO_0050588 GO:0050585 biolink:MolecularActivity 4-hydroxymandelate synthase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2. EC:1.13.11.46|MetaCyc:1.13.11.46-RXN|RHEA:21376 go.json 4-hydroxyphenylpyruvate dioxygenase II activity|4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0050585 GO:0001578 biolink:BiologicalProcess microtubule bundle formation A process that results in a parallel arrangement of microtubules. go.json microtubule bundling http://purl.obolibrary.org/obo/GO_0001578 GO:0098520 biolink:CellularComponent excitatory neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0098520 GO:0050586 biolink:MolecularActivity 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H+ + O2 = N-acetylanthranilate + CO. EC:1.13.11.48|KEGG_REACTION:R05720|MetaCyc:1.13.11.48-RXN|RHEA:21572 go.json (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity|1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity|1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity|3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)|3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity http://purl.obolibrary.org/obo/GO_0050586 GO:0001579 biolink:BiologicalProcess medium-chain fatty acid transport The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. go.json http://purl.obolibrary.org/obo/GO_0001579 GO:0001572 biolink:BiologicalProcess lactosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. go.json lactosylceramide anabolism|lactosylceramide biosynthesis|lactosylceramide formation|lactosylceramide synthesis http://purl.obolibrary.org/obo/GO_0001572 GO:0001573 biolink:BiologicalProcess ganglioside metabolic process The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. go.json ganglioside metabolism http://purl.obolibrary.org/obo/GO_0001573 GO:0050589 biolink:MolecularActivity leucocyanidin oxygenase activity Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O. EC:1.14.20.4|MetaCyc:RXN-602 go.json anthocyanidin synthase activity|leucoanthocyanidin dioxygenase activity|leucoanthocyanidin hydroxylase|leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050589 GO:0001574 biolink:BiologicalProcess ganglioside biosynthetic process The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. go.json ganglioside anabolism|ganglioside biosynthesis|ganglioside formation|ganglioside synthesis http://purl.obolibrary.org/obo/GO_0001574 GO:0001575 biolink:BiologicalProcess globoside metabolic process The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes. go.json globoside metabolism http://purl.obolibrary.org/obo/GO_0001575 GO:0001570 biolink:BiologicalProcess vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. Wikipedia:Vasculogenesis go.json vascular morphogenesis http://purl.obolibrary.org/obo/GO_0001570 GO:0001571 biolink:MolecularActivity non-tyrosine kinase fibroblast growth factor receptor activity Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity. go.json non-tyrosine kinase FGF receptor activity|non-tyrosine kinase FGFR activity http://purl.obolibrary.org/obo/GO_0001571 GO:0098529 biolink:BiologicalProcess neuromuscular junction development, skeletal muscle fiber A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber. go.json http://purl.obolibrary.org/obo/GO_0098529 GO:0050580 biolink:MolecularActivity 2,5-didehydrogluconate reductase activity Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+. EC:1.1.1.274|MetaCyc:1.1.1.274-RXN|RHEA:23828 go.json 2,5-diketo-D-gluconate reductase activity|2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity|YqhE reductase http://purl.obolibrary.org/obo/GO_0050580 GO:0098527 biolink:CellularComponent neuromuscular junction of somatic muscle A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods. go.json http://purl.obolibrary.org/obo/GO_0098527 GO:0098528 biolink:BiologicalProcess skeletal muscle fiber differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. go.json http://purl.obolibrary.org/obo/GO_0098528 GO:0050583 biolink:MolecularActivity hydrogen dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + H2 = NADPH + H+. EC:1.12.1.3|MetaCyc:1.12.1.3-RXN|RHEA:18637 go.json NADP-linked hydrogenase activity|NADP-reducing hydrogenase activity|hydrogen:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050583 GO:0098525 biolink:CellularComponent excitatory neuromuscular junction of somatic myotube A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells. go.json http://purl.obolibrary.org/obo/GO_0098525 GO:0098526 biolink:CellularComponent inhibitory neuromuscular junction of somatic myotube A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods. go.json http://purl.obolibrary.org/obo/GO_0098526 GO:0050584 biolink:MolecularActivity linoleate 11-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate. EC:1.13.11.45|KEGG_REACTION:R05718|MetaCyc:1.13.11.45-RXN|RHEA:18993 go.json linoleate dioxygenase activity|linoleate:oxygen 11S-oxidoreductase activity|manganese lipoxygenase activity http://purl.obolibrary.org/obo/GO_0050584 GO:0050581 biolink:MolecularActivity D-mannitol oxidase activity Catalysis of the reaction: mannitol + O2 = mannose + H2O2. EC:1.1.3.40|MetaCyc:1.1.3.40-RXN|RHEA:18513 go.json D-arabinitol oxidase activity|D-arabitol oxidase activity|mannitol oxidase activity|mannitol:oxygen oxidoreductase (cyclizing) http://purl.obolibrary.org/obo/GO_0050581 GO:0098523 biolink:CellularComponent neuromuscular junction of myotube A neuromuscular junction in which the target muscle cell is a myotube. go.json http://purl.obolibrary.org/obo/GO_0098523 GO:0050582 biolink:MolecularActivity xylitol oxidase activity Catalysis of the reaction: xylitol + O2 = xylose + H2O2. EC:1.1.3.41|MetaCyc:1.1.3.41-RXN go.json xylitol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050582 GO:0098524 biolink:CellularComponent neuromuscular junction of somatic muscle myotube A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell. go.json http://purl.obolibrary.org/obo/GO_0098524 GO:0050598 biolink:MolecularActivity taxane 13-alpha-hydroxylase activity Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol. EC:1.14.14.106|KEGG_REACTION:R06308|MetaCyc:1.14.13.77-RXN|RHEA:18949 go.json taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)|taxane 13a-hydroxylase activity|taxane 13alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050598 GO:0098532 biolink:BiologicalProcess histone H3-K27 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone. go.json http://purl.obolibrary.org/obo/GO_0098532 gocheck_do_not_annotate GO:0001587 biolink:MolecularActivity Gq/11-coupled serotonin receptor activity Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. go.json 5-HT2 receptor activity|serotonin receptor activity, coupled via Gq/11 http://purl.obolibrary.org/obo/GO_0001587 GO:0050599 biolink:MolecularActivity deacetoxycephalosporin-C synthase activity Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate. EC:1.14.20.1|KEGG_REACTION:R05301|MetaCyc:1.14.20.1-RXN|RHEA:20748 go.json DAOC synthase activity|DAOCS activity|deacetoxycephalosporin C synthetase activity|expandase activity|penicillin N expandase activity|penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding) http://purl.obolibrary.org/obo/GO_0050599 GO:0001588 biolink:MolecularActivity dopamine neurotransmitter receptor activity, coupled via Gs Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. go.json dopamine D1 receptor activity|dopamine D5 receptor activity http://purl.obolibrary.org/obo/GO_0001588 GO:0098533 biolink:CellularComponent ATPase dependent transmembrane transport complex A transmembrane protein complex that functions in ATPase dependent active transport across a membrane. go.json http://purl.obolibrary.org/obo/GO_0098533 GO:0050596 biolink:MolecularActivity vinorine hydroxylase activity Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine. EC:1.14.14.104|KEGG_REACTION:R05877|MetaCyc:1.14.13.75-RXN|RHEA:17257 go.json vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating) http://purl.obolibrary.org/obo/GO_0050596 GO:0098530 biolink:BiologicalProcess positive regulation of strand invasion Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. go.json positive regulation of D-loop biosynthesis|positive regulation of D-loop formation|positive regulation of Rad51-mediated strand invasion http://purl.obolibrary.org/obo/GO_0098530 GO:0001589 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001589 GO:0050597 biolink:MolecularActivity taxane 10-beta-hydroxylase activity Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+. EC:1.14.14.105|KEGG_REACTION:R06309|MetaCyc:1.14.13.76-RXN|RHEA:15241 go.json 5-alpha-taxadienol-10-beta-hydroxylase activity|taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)|taxane 10b-hydroxylase activity|taxane 10beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050597 GO:0098531 biolink:MolecularActivity ligand-activated transcription factor activity A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. go.json direct ligand regulated sequence-specific DNA binding transcription factor activity|transcription factor activity, direct ligand regulated sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0098531 GO:0001583 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of salty taste The series of events required for a salty taste stimulus to be received and converted to a molecular signal. go.json perception of salty taste, detection of chemical stimulus|perception of salty taste, sensory transduction of chemical stimulus|salty taste detection|sensory detection of chemical stimulus during perception of salty taste|sensory detection of salty taste|sensory transduction of chemical stimulus during perception of salty taste|sensory transduction of salty taste http://purl.obolibrary.org/obo/GO_0001583 GO:0001584 biolink:MolecularActivity obsolete rhodopsin-like receptor activity OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor. go.json Class A G protein coupled receptor|Class A G-protein coupled receptor|Class A GPCR|class A orphan receptor activity|rhodopsin-like receptor activity True http://purl.obolibrary.org/obo/GO_0001584 GO:1902108 biolink:BiologicalProcess regulation of mitochondrial membrane permeability involved in apoptotic process Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. go.json regulation of mitochondrial membrane permeability involved in apoptosis|regulation of mitochondrial membrane permeability involved in apoptotic cell death|regulation of mitochondrial membrane permeability involved in apoptotic program|regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death|regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis|regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity|regulation of mitochondrial membrane permeability involved in type I programmed cell death|regulation of transport across mitochondrial membrane involved in apoptosis|regulation of transport across mitochondrial membrane involved in apoptotic cell death|regulation of transport across mitochondrial membrane involved in apoptotic process|regulation of transport across mitochondrial membrane involved in apoptotic program|regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death|regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis|regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity|regulation of transport across mitochondrial membrane involved in type I programmed cell death http://purl.obolibrary.org/obo/GO_1902108 GO:0001585 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001585 GO:1902109 biolink:BiologicalProcess negative regulation of mitochondrial membrane permeability involved in apoptotic process Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process. go.json mitochondrial membrane impermeability involved in apoptosis|mitochondrial membrane impermeability involved in apoptotic cell death|mitochondrial membrane impermeability involved in apoptotic process|mitochondrial membrane impermeability involved in apoptotic program|mitochondrial membrane impermeability involved in apoptotic programmed cell death|mitochondrial membrane impermeability involved in programmed cell death by apoptosis|mitochondrial membrane impermeability involved in signaling (initiator) caspase activity|mitochondrial membrane impermeability involved in type I programmed cell death|mitochondrial membrane impermeabilization involved in apoptosis|mitochondrial membrane impermeabilization involved in apoptotic cell death|mitochondrial membrane impermeabilization involved in apoptotic process|mitochondrial membrane impermeabilization involved in apoptotic program|mitochondrial membrane impermeabilization involved in apoptotic programmed cell death|mitochondrial membrane impermeabilization involved in programmed cell death by apoptosis|mitochondrial membrane impermeabilization involved in signaling (initiator) caspase activity|mitochondrial membrane impermeabilization involved in type I programmed cell death|negative regulation of mitochondrial membrane permeability involved in apoptosis|negative regulation of mitochondrial membrane permeability involved in apoptotic cell death|negative regulation of mitochondrial membrane permeability involved in apoptotic program|negative regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death|negative regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis|negative regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity|negative regulation of mitochondrial membrane permeability involved in type I programmed cell death|negative regulation of transport across mitochondrial membrane involved in apoptosis|negative regulation of transport across mitochondrial membrane involved in apoptotic cell death|negative regulation of transport across mitochondrial membrane involved in apoptotic process|negative regulation of transport across mitochondrial membrane involved in apoptotic program|negative regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death|negative regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis|negative regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity|negative regulation of transport across mitochondrial membrane involved in type I programmed cell death http://purl.obolibrary.org/obo/GO_1902109 GO:0001586 biolink:MolecularActivity Gi/o-coupled serotonin receptor activity Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. go.json 5-HT1 receptor activity|serotonin receptor activity, coupled via Gi/o http://purl.obolibrary.org/obo/GO_0001586 GO:1902106 biolink:BiologicalProcess negative regulation of leukocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. go.json down regulation of immune cell differentiation|down regulation of leucocyte differentiation|down regulation of leukocyte differentiation|down-regulation of immune cell differentiation|down-regulation of leucocyte differentiation|down-regulation of leukocyte differentiation|downregulation of immune cell differentiation|downregulation of leucocyte differentiation|downregulation of leukocyte differentiation|inhibition of immune cell differentiation|inhibition of leucocyte differentiation|inhibition of leukocyte differentiation|negative regulation of immune cell differentiation|negative regulation of leucocyte differentiation http://purl.obolibrary.org/obo/GO_1902106 GO:1902107 biolink:BiologicalProcess positive regulation of leukocyte differentiation Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. go.json activation of immune cell differentiation|activation of leucocyte differentiation|activation of leukocyte differentiation|positive regulation of immune cell differentiation|positive regulation of leucocyte differentiation|up regulation of immune cell differentiation|up regulation of leucocyte differentiation|up regulation of leukocyte differentiation|up-regulation of immune cell differentiation|up-regulation of leucocyte differentiation|up-regulation of leukocyte differentiation|upregulation of immune cell differentiation|upregulation of leucocyte differentiation|upregulation of leukocyte differentiation http://purl.obolibrary.org/obo/GO_1902107 GO:0001580 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of bitter taste The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. go.json bitter taste detection|perception of bitter taste, detection of chemical stimulus|perception of bitter taste, sensory transduction of chemical stimulus|sensory detection of bitter taste|sensory detection of chemical stimulus during perception of bitter taste|sensory transduction of bitter taste|sensory transduction of chemical stimulus during perception of bitter taste http://purl.obolibrary.org/obo/GO_0001580 GO:0001581 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of sour taste The series of events required for a sour taste stimulus to be received and converted to a molecular signal. go.json perception of sour taste, detection of chemical stimulus|perception of sour taste, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during perception of sour taste|sensory detection of sour taste|sensory transduction of chemical stimulus during perception of sour taste|sensory transduction of sour taste|sour taste detection http://purl.obolibrary.org/obo/GO_0001581 GO:1902104 biolink:BiologicalProcess positive regulation of metaphase/anaphase transition of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. go.json activation of meiotic metaphase/anaphase transition|activation of metaphase/anaphase transition of meiotic cell cycle|positive regulation of meiotic metaphase/anaphase transition|up regulation of meiotic metaphase/anaphase transition|up regulation of metaphase/anaphase transition of meiotic cell cycle|up-regulation of meiotic metaphase/anaphase transition|up-regulation of metaphase/anaphase transition of meiotic cell cycle|upregulation of meiotic metaphase/anaphase transition|upregulation of metaphase/anaphase transition of meiotic cell cycle http://purl.obolibrary.org/obo/GO_1902104 GO:1902105 biolink:BiologicalProcess regulation of leukocyte differentiation Any process that modulates the frequency, rate or extent of leukocyte differentiation. go.json regulation of immune cell differentiation|regulation of leucocyte differentiation http://purl.obolibrary.org/obo/GO_1902105 GO:0001582 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of sweet taste The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. go.json perception of sweet taste, detection of chemical stimulus|perception of sweet taste, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during perception of sweet taste|sensory detection of sweet taste|sensory transduction of chemical stimulus during perception of sweet taste|sensory transduction of sweet taste|sweet taste detection http://purl.obolibrary.org/obo/GO_0001582 GO:1902102 biolink:BiologicalProcess regulation of metaphase/anaphase transition of meiotic cell cycle Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. go.json regulation of meiotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1902102 GO:1902103 biolink:BiologicalProcess negative regulation of metaphase/anaphase transition of meiotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. go.json down regulation of meiotic metaphase/anaphase transition|down regulation of metaphase/anaphase transition of meiotic cell cycle|down-regulation of meiotic metaphase/anaphase transition|down-regulation of metaphase/anaphase transition of meiotic cell cycle|downregulation of meiotic metaphase/anaphase transition|downregulation of metaphase/anaphase transition of meiotic cell cycle|inhibition of meiotic metaphase/anaphase transition|inhibition of metaphase/anaphase transition of meiotic cell cycle|negative regulation of meiotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1902103 GO:1902100 biolink:BiologicalProcess negative regulation of metaphase/anaphase transition of cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle. go.json down regulation of metaphase/anaphase transition of cell cycle|down-regulation of metaphase/anaphase transition of cell cycle|downregulation of metaphase/anaphase transition of cell cycle|inhibition of metaphase/anaphase transition of cell cycle http://purl.obolibrary.org/obo/GO_1902100 GO:1902101 biolink:BiologicalProcess positive regulation of metaphase/anaphase transition of cell cycle Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. go.json activation of metaphase/anaphase transition of cell cycle|up regulation of metaphase/anaphase transition of cell cycle|up-regulation of metaphase/anaphase transition of cell cycle|upregulation of metaphase/anaphase transition of cell cycle http://purl.obolibrary.org/obo/GO_1902101 GO:1902110 biolink:BiologicalProcess positive regulation of mitochondrial membrane permeability involved in apoptotic process Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process. go.json mitochondrial membrane permeability transition involved in apoptosis|mitochondrial membrane permeability transition involved in apoptotic cell death|mitochondrial membrane permeability transition involved in apoptotic process|mitochondrial membrane permeability transition involved in apoptotic program|mitochondrial membrane permeability transition involved in apoptotic programmed cell death|mitochondrial membrane permeability transition involved in programmed cell death by apoptosis|mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in type I programmed cell death|mitochondrial membrane permeabilization involved in apoptosis|mitochondrial membrane permeabilization involved in apoptotic cell death|mitochondrial membrane permeabilization involved in apoptotic process|mitochondrial membrane permeabilization involved in apoptotic program|mitochondrial membrane permeabilization involved in apoptotic programmed cell death|mitochondrial membrane permeabilization involved in programmed cell death by apoptosis|mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity|mitochondrial membrane permeabilization involved in type I programmed cell death|mitochondrial permeability transition involved in apoptosis|mitochondrial permeability transition involved in apoptotic cell death|mitochondrial permeability transition involved in apoptotic process|mitochondrial permeability transition involved in apoptotic program|mitochondrial permeability transition involved in apoptotic programmed cell death|mitochondrial permeability transition involved in programmed cell death by apoptosis|mitochondrial permeability transition involved in signaling (initiator) caspase activity|mitochondrial permeability transition involved in type I programmed cell death|positive regulation of mitochondrial membrane permeability involved in apoptosis|positive regulation of mitochondrial membrane permeability involved in apoptotic cell death|positive regulation of mitochondrial membrane permeability involved in apoptotic program|positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis|positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity|positive regulation of mitochondrial membrane permeability involved in type I programmed cell death|positive regulation of transport across mitochondrial membrane involved in apoptosis|positive regulation of transport across mitochondrial membrane involved in apoptotic cell death|positive regulation of transport across mitochondrial membrane involved in apoptotic process|positive regulation of transport across mitochondrial membrane involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death|positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis|positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity|positive regulation of transport across mitochondrial membrane involved in type I programmed cell death http://purl.obolibrary.org/obo/GO_1902110 GO:0050590 biolink:MolecularActivity desacetoxyvindoline 4-hydroxylase activity Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2. EC:1.14.11.20|KEGG_REACTION:R05857|MetaCyc:1.14.11.20-RXN|RHEA:18973 go.json D17H activity|deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)|desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity|desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)|desacetoxyvindoline-4-hydroxylase activity|desacetyoxyvindoline-17-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050590 GO:0050591 biolink:MolecularActivity quinine 3-monooxygenase activity Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+. EC:1.14.14.55|KEGG_REACTION:R05727|MetaCyc:1.14.13.67-RXN|RHEA:20149 go.json nifedipine oxidase activity|quinine 3-hydroxylase activity|quinine,NADPH:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050591 GO:0098538 biolink:CellularComponent lumenal side of transport vesicle membrane The side (leaflet) of the transport vesicle membrane that faces the lumen. go.json internal side of transport vesicle membrane http://purl.obolibrary.org/obo/GO_0098538 GO:0098539 biolink:CellularComponent cytoplasmic side of transport vesicle membrane The side (leaflet) of the transport vesicle membrane that faces the cytoplasm. go.json external side of transport vesicle membrane http://purl.obolibrary.org/obo/GO_0098539 GO:0098536 biolink:CellularComponent deuterosome A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles. go.json http://purl.obolibrary.org/obo/GO_0098536 GO:0050594 biolink:MolecularActivity tabersonine 16-hydroxylase activity Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+. EC:1.14.14.103|KEGG_REACTION:R05855|MetaCyc:1.14.13.73-RXN|RHEA:14133 go.json tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating) http://purl.obolibrary.org/obo/GO_0050594 GO:0098537 biolink:CellularComponent obsolete lobed nucleus OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans. go.json True http://purl.obolibrary.org/obo/GO_0098537 GO:0050595 biolink:MolecularActivity 7-deoxyloganin 7-hydroxylase activity Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.85|MetaCyc:1.14.13.74-RXN|RHEA:11452 go.json http://purl.obolibrary.org/obo/GO_0050595 GO:0050592 biolink:MolecularActivity 4-hydroxyphenylacetaldehyde oxime monooxygenase activity Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+. EC:1.14.14.37|KEGG_REACTION:R05728|MetaCyc:1.14.13.68-RXN|RHEA:18401 go.json (Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity|4-hydroxybenzeneacetaldehyde oxime monooxygenase activity|4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity|CYP71E1 activity|NADPH-cytochrome P450 reductase (CYP71E1)|cytochrome P450-II-dependent monooxygenase activity|cytochrome P450II-dependent monooxygenase activity http://purl.obolibrary.org/obo/GO_0050592 GO:0098534 biolink:BiologicalProcess centriole assembly A cellular process that results in the assembly of one or more centrioles. go.json http://purl.obolibrary.org/obo/GO_0098534 GO:0098535 biolink:BiologicalProcess de novo centriole assembly involved in multi-ciliated epithelial cell differentiation Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation. go.json centriole amplification|de novo centriole assembly|de novo centriole assembly via deuterosome|deuterosomal basal body biogenesis|deuterosome pathway|deuterosome-mediated centriole biogenesis|multiciliation|multiciliogenesis http://purl.obolibrary.org/obo/GO_0098535 GO:0050593 biolink:MolecularActivity N-methylcoclaurine 3'-monooxygenase activity Catalysis of the reaction: (S)-N-methylcoclaurine + H+ + NADPH + O2 = (S)-3'-hydroxy-N-methylcoclaurine + H2O + NADP+. EC:1.14.14.102|KEGG_REACTION:R05732|MetaCyc:1.14.13.71-RXN|RHEA:16649 go.json (S)-N-methylcoclaurine 3'-hydroxylase activity|(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)|N-methylcoclaurine 3'-hydroxylase activity|cytochrome P450 80B1 activity http://purl.obolibrary.org/obo/GO_0050593 GO:0001554 biolink:BiologicalProcess luteolysis The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy. Wikipedia:Luteolysis go.json http://purl.obolibrary.org/obo/GO_0001554 GO:0001555 biolink:BiologicalProcess oocyte growth The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. go.json http://purl.obolibrary.org/obo/GO_0001555 GO:0001556 biolink:BiologicalProcess oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. Wikipedia:Oocyte_maturation go.json http://purl.obolibrary.org/obo/GO_0001556 GO:0001557 biolink:BiologicalProcess obsolete metabolic process resulting in cell growth OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell. go.json metabolic process resulting in cell growth True http://purl.obolibrary.org/obo/GO_0001557 GO:0001550 biolink:BiologicalProcess ovarian cumulus expansion Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells. go.json ovarian cumulus growth http://purl.obolibrary.org/obo/GO_0001550 GO:0001551 biolink:BiologicalProcess ovarian follicle endowment Association of oocytes with supporting epithelial granulosa cells to form primordial follicles. go.json http://purl.obolibrary.org/obo/GO_0001551 GO:1902119 biolink:BiologicalProcess regulation of meiotic spindle elongation Any process that modulates the frequency, rate or extent of meiotic spindle elongation. go.json regulation of spindle elongation during meiosis http://purl.obolibrary.org/obo/GO_1902119 GO:0001552 biolink:BiologicalProcess ovarian follicle atresia A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed. go.json http://purl.obolibrary.org/obo/GO_0001552 GO:0001553 biolink:BiologicalProcess luteinization The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation. Wikipedia:Luteal_phase|Wikipedia:Luteinization go.json luteal phase http://purl.obolibrary.org/obo/GO_0001553 GO:1902117 biolink:BiologicalProcess positive regulation of organelle assembly Any process that activates or increases the frequency, rate or extent of organelle assembly. go.json activation of organelle assembly|up regulation of organelle assembly|up-regulation of organelle assembly|upregulation of organelle assembly http://purl.obolibrary.org/obo/GO_1902117 GO:1902118 biolink:MolecularActivity calcidiol binding Binding to calcidiol. go.json 25(OH)D3 binding|25-hydroxycholecalciferol binding|25-hydroxyvitamin D3 binding|25OHD3 binding|calcifediol binding http://purl.obolibrary.org/obo/GO_1902118 GO:1902115 biolink:BiologicalProcess regulation of organelle assembly Any process that modulates the frequency, rate or extent of organelle assembly. go.json http://purl.obolibrary.org/obo/GO_1902115 GO:1902116 biolink:BiologicalProcess negative regulation of organelle assembly Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. go.json down regulation of organelle assembly|down-regulation of organelle assembly|downregulation of organelle assembly|inhibition of organelle assembly http://purl.obolibrary.org/obo/GO_1902116 GO:1902113 biolink:BiologicalProcess obsolete nucleotide phosphorylation involved in DNA repair OBSOLETE. Any nucleotide phosphorylation that is involved in DNA repair. go.json True http://purl.obolibrary.org/obo/GO_1902113 GO:1902114 biolink:BiologicalProcess D-valine metabolic process The chemical reactions and pathways involving D-valine. go.json D-valine metabolism http://purl.obolibrary.org/obo/GO_1902114 GO:1902111 biolink:BiologicalProcess response to diethyl maleate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus. go.json http://purl.obolibrary.org/obo/GO_1902111 GO:1902112 biolink:BiologicalProcess cellular response to diethyl maleate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus. go.json http://purl.obolibrary.org/obo/GO_1902112 GO:1902120 biolink:BiologicalProcess negative regulation of meiotic spindle elongation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation. go.json down regulation of meiotic spindle elongation|down regulation of spindle elongation during meiosis|down-regulation of meiotic spindle elongation|down-regulation of spindle elongation during meiosis|downregulation of meiotic spindle elongation|downregulation of spindle elongation during meiosis|inhibition of meiotic spindle elongation|inhibition of spindle elongation during meiosis|negative regulation of spindle elongation during meiosis http://purl.obolibrary.org/obo/GO_1902120 GO:1902121 biolink:MolecularActivity lithocholic acid binding Binding to lithocholic acid. go.json LCA binding http://purl.obolibrary.org/obo/GO_1902121 GO:0098509 biolink:BiologicalProcess sensory perception of humidity The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json hygrosensory perception http://purl.obolibrary.org/obo/GO_0098509 GO:0098507 biolink:BiologicalProcess polynucleotide 5' dephosphorylation The process of removing one or more phosphate groups from the 5' end of a polynucleotide. go.json http://purl.obolibrary.org/obo/GO_0098507 GO:0098508 biolink:BiologicalProcess endothelial to hematopoietic transition The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium. go.json http://purl.obolibrary.org/obo/GO_0098508 GO:0098505 biolink:MolecularActivity G-rich strand telomeric DNA binding Binding to G-rich, single-stranded, telomere-associated DNA. go.json http://purl.obolibrary.org/obo/GO_0098505 GO:0098506 biolink:BiologicalProcess polynucleotide 3' dephosphorylation The process of removing one or more phosphate groups from the 3' end of a polynucleotide. go.json http://purl.obolibrary.org/obo/GO_0098506 GO:0098503 biolink:BiologicalProcess obsolete DNA 3' dephosphorylation OBSOLETE. The process of removing a 3' phosphate group from a DNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0098503 GO:0001558 biolink:BiologicalProcess regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth. go.json http://purl.obolibrary.org/obo/GO_0001558 GO:0001559 biolink:BiologicalProcess obsolete regulation of cell growth by detection of nuclear:cytoplasmic ratio OBSOLETE. Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. go.json detection of nuclear:cytoplasmic ratio to regulate cell growth|interpretation of nuclear:cytoplasmic ratio to regulate cell growth|regulation of cell growth by nuclear:cytoplasmic ratio|regulation of cell growth by sensing of nuclear:cytoplasmic ratio True http://purl.obolibrary.org/obo/GO_0001559 GO:0098504 biolink:BiologicalProcess obsolete DNA 3' dephosphorylation involved in DNA repair OBSOLETE. Any 3' DNA dephosphorylation that is involved in the process of DNA repair. go.json True http://purl.obolibrary.org/obo/GO_0098504 GO:0098501 biolink:BiologicalProcess obsolete polynucleotide dephosphorylation OBSOLETE. The process of removing one or more phosphate groups from a polynucleotide. go.json True http://purl.obolibrary.org/obo/GO_0098501 GO:0098502 biolink:BiologicalProcess obsolete DNA dephosphorylation OBSOLETE. The process of removing one or more phosphate groups from a DNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0098502 GO:0098510 biolink:BiologicalProcess sensory perception of high humidity The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json http://purl.obolibrary.org/obo/GO_0098510 GO:0001565 biolink:MolecularActivity phorbol ester receptor activity Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001565 GO:0098511 biolink:BiologicalProcess sensory perception of low humidity The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json http://purl.obolibrary.org/obo/GO_0098511 GO:0001566 biolink:MolecularActivity non-kinase phorbol ester receptor activity Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity. go.json http://purl.obolibrary.org/obo/GO_0001566 GO:0001567 biolink:MolecularActivity cholesterol 25-hydroxylase activity Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O. EC:1.14.99.38|KEGG_REACTION:R07218|MetaCyc:1.14.99.38-RXN|RHEA:21104 go.json cholesterol 25-monooxygenase activity|cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0001567 GO:0001568 biolink:BiologicalProcess blood vessel development The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. go.json http://purl.obolibrary.org/obo/GO_0001568 GO:0001561 biolink:BiologicalProcess fatty acid alpha-oxidation A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. MetaCyc:PWY-2501 go.json http://purl.obolibrary.org/obo/GO_0001561 GO:0001562 biolink:BiologicalProcess response to protozoan Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. go.json resistance to pathogenic protozoa|response to protozoa|response to protozoon http://purl.obolibrary.org/obo/GO_0001562 GO:0001563 biolink:BiologicalProcess detection of protozoan The series of events in which a stimulus from a protozoan is received and converted into a molecular signal. go.json detection of protozoa|detection of protozoon|perception of protozoa http://purl.obolibrary.org/obo/GO_0001563 GO:0001564 biolink:BiologicalProcess obsolete resistance to pathogenic protozoa OBSOLETE. (Was not defined before being made obsolete). go.json resistance to pathogenic protozoa True http://purl.obolibrary.org/obo/GO_0001564 GO:1902128 biolink:BiologicalProcess (-)-lariciresinol catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-lariciresinol. go.json (-)-lariciresinol breakdown|(-)-lariciresinol catabolism|(-)-lariciresinol degradation http://purl.obolibrary.org/obo/GO_1902128 GO:1902129 biolink:BiologicalProcess (-)-lariciresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-lariciresinol. go.json (-)-lariciresinol anabolism|(-)-lariciresinol biosynthesis|(-)-lariciresinol formation|(-)-lariciresinol synthesis http://purl.obolibrary.org/obo/GO_1902129 GO:1902126 biolink:BiologicalProcess (+)-pinoresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-pinoresinol. go.json (+)-pinoresinol anabolism|(+)-pinoresinol biosynthesis|(+)-pinoresinol formation|(+)-pinoresinol synthesis http://purl.obolibrary.org/obo/GO_1902126 GO:1902127 biolink:BiologicalProcess (-)-lariciresinol metabolic process The chemical reactions and pathways involving (-)-lariciresinol. go.json (-)-lariciresinol metabolism http://purl.obolibrary.org/obo/GO_1902127 GO:0001560 biolink:BiologicalProcess regulation of cell growth by extracellular stimulus Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. go.json interpretation of external signals that regulate cell growth|regulation of cell growth by detection of exogenous stimulus|regulation of cell growth by sensing of exogenous stimulus|regulation of growth by exogenous signal|regulation of growth by exogenous stimuli|regulation of growth by exogenous stimulus|regulation of growth by external signal|regulation of growth by external stimuli|regulation of growth by external stimulus http://purl.obolibrary.org/obo/GO_0001560 GO:1902124 biolink:BiologicalProcess (+)-pinoresinol metabolic process The chemical reactions and pathways involving (+)-pinoresinol. go.json (+)-pinoresinol metabolism http://purl.obolibrary.org/obo/GO_1902124 GO:1902125 biolink:BiologicalProcess (+)-pinoresinol catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-pinoresinol. go.json (+)-pinoresinol breakdown|(+)-pinoresinol catabolism|(+)-pinoresinol degradation http://purl.obolibrary.org/obo/GO_1902125 GO:1902122 biolink:MolecularActivity chenodeoxycholic acid binding Binding to chenodeoxycholic acid. go.json CDCA binding http://purl.obolibrary.org/obo/GO_1902122 GO:1902123 biolink:BiologicalProcess (-)-pinoresinol catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-pinoresinol. go.json (-)-pinoresinol breakdown|(-)-pinoresinol catabolism|(-)-pinoresinol degradation http://purl.obolibrary.org/obo/GO_1902123 GO:1902131 biolink:BiologicalProcess (+)-lariciresinol catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-lariciresinol. go.json (+)-lariciresinol breakdown|(+)-lariciresinol catabolism|(+)-lariciresinol degradation http://purl.obolibrary.org/obo/GO_1902131 GO:1902132 biolink:BiologicalProcess (+)-lariciresinol biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-lariciresinol. go.json (+)-lariciresinol anabolism|(+)-lariciresinol biosynthesis|(+)-lariciresinol formation|(+)-lariciresinol synthesis http://purl.obolibrary.org/obo/GO_1902132 GO:1902130 biolink:BiologicalProcess (+)-lariciresinol metabolic process The chemical reactions and pathways involving (+)-lariciresinol. go.json (+)-lariciresinol metabolism http://purl.obolibrary.org/obo/GO_1902130 GO:0098518 biolink:MolecularActivity obsolete polynucleotide phosphatase activity OBSOLETE. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. go.json True http://purl.obolibrary.org/obo/GO_0098518 GO:0098519 biolink:MolecularActivity obsolete nucleotide phosphatase activity, acting on free nucleotides OBSOLETE. Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate. go.json nucleotide phosphatase activity True http://purl.obolibrary.org/obo/GO_0098519 GO:0098516 biolink:BiologicalProcess detection of high humidity The series of events in which high humidity is detected and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0098516 GO:0098517 biolink:BiologicalProcess detection of low humidity The series of events in which low humidity is detected and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0098517 GO:0001569 biolink:BiologicalProcess branching involved in blood vessel morphogenesis The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. go.json patterning of blood vessels http://purl.obolibrary.org/obo/GO_0001569 GO:0098514 biolink:BiologicalProcess detection of high humidity stimulus involved in sensory perception The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity. go.json http://purl.obolibrary.org/obo/GO_0098514 GO:0098515 biolink:BiologicalProcess detection of low humidity stimulus involved in sensory perception The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity. go.json http://purl.obolibrary.org/obo/GO_0098515 GO:0098512 biolink:BiologicalProcess detection of humidity stimulus involved in sensory perception The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity. go.json http://purl.obolibrary.org/obo/GO_0098512 GO:0098513 biolink:BiologicalProcess detection of humidity The series of events in which a humidity stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0098513 GO:1990673 biolink:CellularComponent obsolete intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane OBSOLETE. The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane True http://purl.obolibrary.org/obo/GO_1990673 GO:1990674 biolink:CellularComponent Golgi cis cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex. go.json Golgi apparatus cis cisterna membrane|cis-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990674 GO:0050500 biolink:MolecularActivity 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate. EC:2.4.1.211|MetaCyc:2.4.1.211-RXN|RHEA:20285 go.json beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity|beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity|beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0050500 GO:1990675 biolink:CellularComponent Golgi medial cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex. go.json Golgi apparatus medial cisterna membrane|medial-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990675 GO:1990676 biolink:CellularComponent Golgi trans cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex. go.json trans-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990676 GO:0050503 biolink:MolecularActivity trehalose 6-phosphate phosphorylase activity Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate. EC:2.4.1.216|MetaCyc:2.4.1.216-RXN|RHEA:20864 go.json trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050503 GO:0050504 biolink:MolecularActivity mannosyl-3-phosphoglycerate synthase activity Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H+. EC:2.4.1.217|KEGG_REACTION:R05768|MetaCyc:2.4.1.217-RXN|RHEA:13537 go.json GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity|MPG synthase activity http://purl.obolibrary.org/obo/GO_0050504 GO:1990670 biolink:BiologicalProcess vesicle fusion with Golgi cis cisterna membrane The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles. go.json http://purl.obolibrary.org/obo/GO_1990670 GO:0050501 biolink:MolecularActivity hyaluronan synthase activity Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. EC:2.4.1.212|MetaCyc:2.4.1.212-RXN|RHEA:12528|Reactome:R-HSA-2160851 go.json HAS activity|alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity|alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity|seHAS|spHAS http://purl.obolibrary.org/obo/GO_0050501 GO:1990671 biolink:BiologicalProcess vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles. go.json http://purl.obolibrary.org/obo/GO_1990671 GO:1990672 biolink:BiologicalProcess medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport. go.json http://purl.obolibrary.org/obo/GO_1990672 GO:0050502 biolink:MolecularActivity cis-zeatin O-beta-D-glucosyltransferase activity Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H+ + UDP. EC:2.4.1.215|KEGG_REACTION:R07260|MetaCyc:RXN-4735|RHEA:20681 go.json UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity|UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity|cis-zeatin O-b-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050502 GO:0050507 biolink:MolecularActivity indoxyl-UDPG glucosyltransferase activity Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP. EC:2.4.1.220|KEGG_REACTION:R06048|MetaCyc:2.4.1.220-RXN|RHEA:12004 go.json UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity|indoxyl-UDPG-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050507 GO:0050508 biolink:MolecularActivity glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. EC:2.4.1.224|MetaCyc:2.4.1.224-RXN|RHEA:16213|Reactome:R-HSA-2022851|Reactome:R-HSA-2022919|Reactome:R-HSA-3656254|Reactome:R-HSA-3656261|Reactome:R-HSA-9036283|Reactome:R-HSA-9036290 go.json UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|alpha-N-acetylglucosaminyltransferase II activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity|glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0050508 GO:0050505 biolink:MolecularActivity hydroquinone glucosyltransferase activity Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP. EC:2.4.1.218|KEGG_REACTION:R05769|MetaCyc:2.4.1.218-RXN|RHEA:12560 go.json UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity|UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity|arbutin synthase activity|hydroquinone:O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050505 GO:0050506 biolink:MolecularActivity vomilenine glucosyltransferase activity Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP. EC:2.4.1.219|KEGG_REACTION:R05882|MetaCyc:2.4.1.219-RXN|RHEA:19385 go.json UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity|UDPG:vomilenine 21-beta-D-glucosyltransferase activity|UDPG:vomilenine 21beta-D-glucosyltransferase activity|vomilenine-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050506 GO:0050509 biolink:MolecularActivity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. EC:2.4.1.225|MetaCyc:2.4.1.225-RXN|RHEA:20908|Reactome:R-HSA-2022856|Reactome:R-HSA-2076392|Reactome:R-HSA-3656257|Reactome:R-HSA-3656267|Reactome:R-HSA-9036285|Reactome:R-HSA-9036289 go.json N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity|N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity|UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity|heparan glucuronyltransferase II activity http://purl.obolibrary.org/obo/GO_0050509 GO:1990677 biolink:CellularComponent mitochondrial inner membrane assembly complex A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion. go.json INAC complex|inner membrane assembly complex|mitochondrion inner membrane assembly complex http://purl.obolibrary.org/obo/GO_1990677 GO:1990678 biolink:BiologicalProcess histone H4-K16 deacetylation The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone. go.json http://purl.obolibrary.org/obo/GO_1990678 gocheck_do_not_annotate GO:1990679 biolink:BiologicalProcess histone H4-K12 deacetylation The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone. go.json http://purl.obolibrary.org/obo/GO_1990679 gocheck_do_not_annotate GO:0050510 biolink:MolecularActivity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. EC:2.4.1.226|MetaCyc:RXN-16324|Reactome:R-HSA-1971491|Reactome:R-HSA-3595178|Reactome:R-HSA-9632034 go.json N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity|alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity|chondroitin glucuronyltransferase II activity http://purl.obolibrary.org/obo/GO_0050510 GO:1990684 biolink:CellularComponent protein-lipid-RNA complex A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other. go.json miRNA-lipoprotein complex http://purl.obolibrary.org/obo/GO_1990684 GO:0050511 biolink:MolecularActivity undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. EC:2.4.1.227|MetaCyc:RXN-8976|RHEA:23192 go.json MurG transferase activity|UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity|UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity|undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity|undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0050511 GO:1990685 biolink:CellularComponent HDL-containing protein-lipid-RNA complex A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other. go.json http://purl.obolibrary.org/obo/GO_1990685 GO:1990686 biolink:CellularComponent LDL-containing protein-lipid-RNA complex A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other. go.json http://purl.obolibrary.org/obo/GO_1990686 GO:1990687 biolink:BiologicalProcess endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport. go.json ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane|ER-derived vesicle fusion with ERGIC membrane http://purl.obolibrary.org/obo/GO_1990687 GO:1990680 biolink:BiologicalProcess response to melanocyte-stimulating hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates. go.json response to MSH http://purl.obolibrary.org/obo/GO_1990680 GO:0050514 biolink:MolecularActivity homospermidine synthase (spermidine-specific) activity Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine. EC:2.5.1.45|MetaCyc:2.5.1.45-RXN|RHEA:11236 go.json spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming) http://purl.obolibrary.org/obo/GO_0050514 GO:0050515 biolink:MolecularActivity 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+. EC:2.7.1.148|KEGG_REACTION:R05634|MetaCyc:2.7.1.148-RXN|RHEA:18437 go.json 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity|4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity|ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity|CDP-ME kinase activity|CMK activity http://purl.obolibrary.org/obo/GO_0050515 GO:1990681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990681 GO:0050512 biolink:MolecularActivity lactosylceramide 4-alpha-galactosyltransferase activity Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP. EC:2.4.1.228|MetaCyc:2.4.1.228-RXN|RHEA:11924 go.json Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity|Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity|UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity|globotriaosylceramide/CD77 synthase activity|histo-blood group P(k) UDP-galactose activity|histo-blood group Pk UDP-galactose|lactosylceramide 4-a-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0050512 GO:1990682 biolink:CellularComponent CSF1-CSF1R complex A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. go.json CSF1:C-FMS complex|M-CSF:C-FMS complex|M-CSF:CSF1R complex|M-CSF:FMS complex|macrophage colony-stimulating factor:receptor complex http://purl.obolibrary.org/obo/GO_1990682 GO:1990683 biolink:BiologicalProcess DNA double-strand break attachment to nuclear envelope A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs. go.json http://purl.obolibrary.org/obo/GO_1990683 GO:0050513 biolink:MolecularActivity glycoprotein 2-beta-D-xylosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP. EC:2.4.2.38|KEGG_REACTION:R06016|MetaCyc:2.4.2.38-RXN|RHEA:10612 go.json 1,2-beta-xylosyltransferase activity|beta-1,2-xylosyltransferase activity|glycoprotein 2-b-D-xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0050513 GO:0050518 biolink:MolecularActivity 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate. EC:2.7.7.60|KEGG_REACTION:R05633|MetaCyc:2.7.7.60-RXN|RHEA:13429 go.json 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity|4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity|CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity|MCT activity|MEP cytidylyltransferase activity http://purl.obolibrary.org/obo/GO_0050518 GO:0050519 biolink:MolecularActivity holo-citrate lyase synthase activity Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase. EC:2.7.7.61|MetaCyc:2.7.7.61-RXN|RHEA:16333 go.json 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity|CitX|holo-ACP synthase activity http://purl.obolibrary.org/obo/GO_0050519 GO:0050516 biolink:MolecularActivity obsolete inositol polyphosphate multikinase activity OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. EC:2.7.1.151|MetaCyc:2.7.1.151-RXN go.json ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity|ArgRIII|AtIpk2-alpha activity|AtIpk2-beta activity|AtIpk2alpha|AtIpk2beta|IP3/IP4 6-/3-kinase activity|IP3/IP4 dual-specificity 6-/3-kinase activity|IpK2 activity|IpmK|inositol polyphosphate 6-/3-/5-kinase activity|inositol polyphosphate multikinase activity|inositol-polyphosphate multikinase activity True http://purl.obolibrary.org/obo/GO_0050516 GO:0050517 biolink:MolecularActivity obsolete inositol hexakisphosphate kinase activity OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown). go.json ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity|ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity|inositol hexakisphosphate kinase activity|inositol-hexakisphosphate kinase activity True http://purl.obolibrary.org/obo/GO_0050517 GO:1990688 biolink:BiologicalProcess Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. go.json Golgi vesicle fusion with ER-Golgi intermediate compartment membrane|Golgi vesicle fusion with ERGIC membrane http://purl.obolibrary.org/obo/GO_1990688 GO:1990689 biolink:BiologicalProcess endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport. go.json ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane|ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane|ERGIC-derived vesicle fusion with Golgi cis cisterna membrane|ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990689 GO:0050521 biolink:MolecularActivity alpha-glucan, water dikinase activity Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate. EC:2.7.9.4|MetaCyc:2.7.9.4-RXN|RHEA:11668 go.json ATP:alpha-glucan, water phosphotransferase activity|GWD|a-glucan, water dikinase activity|alpha-glucan,water dikinase activity|starch-related R1 protein activity http://purl.obolibrary.org/obo/GO_0050521 GO:1990695 biolink:CellularComponent obsolete intrinsic component of Golgi trans cisterna membrane OBSOLETE. The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic component of trans-Golgi cisterna membrane True http://purl.obolibrary.org/obo/GO_1990695 GO:1990696 biolink:CellularComponent USH2 complex A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7. go.json USH2 quaternary protein complex http://purl.obolibrary.org/obo/GO_1990696 GO:0050522 biolink:MolecularActivity oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP. EC:1.20.98.- go.json http://purl.obolibrary.org/obo/GO_0050522 GO:1990697 biolink:BiologicalProcess protein depalmitoleylation The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein. go.json http://purl.obolibrary.org/obo/GO_1990697 gocheck_do_not_annotate GO:0050520 biolink:MolecularActivity phosphatidylcholine synthase activity Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+. EC:2.7.8.24|KEGG_REACTION:R05794|MetaCyc:2.7.8.24-RXN|RHEA:14597 go.json CDP-diacylglycerol:choline O-phosphatidyltransferase activity|CDP-diglyceride-choline O-phosphatidyltransferase activity|CDPdiglyceride-choline O-phosphatidyltransferase activity|PC synthase activity http://purl.obolibrary.org/obo/GO_0050520 GO:1990698 biolink:MolecularActivity palmitoleoyltransferase activity Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_1990698 GO:1990691 biolink:BiologicalProcess cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport. go.json cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990691 GO:0050525 biolink:MolecularActivity cutinase activity Catalysis of the reaction: cutin + H2O = cutin monomers. EC:3.1.1.74|MetaCyc:3.1.1.74-RXN go.json cutin hydrolase activity http://purl.obolibrary.org/obo/GO_0050525 GO:0050526 biolink:MolecularActivity poly(3-hydroxybutyrate) depolymerase activity Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5. EC:3.1.1.75|MetaCyc:3.1.1.75-RXN|RHEA:11248 go.json PHB depolymerase activity|poly((R)-hydroxyalkanoic acid) depolymerase activity|poly(3HB) depolymerase activity|poly(HA(SCL)) depolymerase activity|poly(HA) depolymerase activity|poly(HASCL) depolymerase activity|poly[(R)-3-hydroxybutyrate] hydrolase activity|poly[(R)-hydroxyalkanoic acid] depolymerase http://purl.obolibrary.org/obo/GO_0050526 GO:1990692 biolink:BiologicalProcess trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. go.json trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990692 GO:0050523 biolink:MolecularActivity obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP. go.json oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors True http://purl.obolibrary.org/obo/GO_0050523 GO:1990693 biolink:CellularComponent obsolete intrinsic component of Golgi cis cisterna membrane OBSOLETE. The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic component of cis-Golgi cisterna membrane True http://purl.obolibrary.org/obo/GO_1990693 GO:0050524 biolink:MolecularActivity coenzyme-B sulfoethylthiotransferase activity Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB. EC:2.8.4.1|KEGG_REACTION:R04541|MetaCyc:METHYL-COM-HTP-RXN|RHEA:12532|UM-BBD_reactionID:r0356 go.json 2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity|coenzyme-B sulphoethylthiotransferase activity|methyl coenzyme M reductase activity|methyl-CoM reductase activity|methyl-coenzyme-M reductase activity http://purl.obolibrary.org/obo/GO_0050524 GO:1990694 biolink:CellularComponent obsolete intrinsic component of Golgi medial cisterna membrane OBSOLETE. The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic component of medial-Golgi cisterna membrane True http://purl.obolibrary.org/obo/GO_1990694 GO:0050529 biolink:MolecularActivity polyneuridine-aldehyde esterase activity Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol. EC:3.1.1.78|KEGG_REACTION:R05825|MetaCyc:3.1.1.78-RXN|RHEA:17501 go.json PNAE activity|polyneuridine aldehyde esterase activity|polyneuridine aldehyde hydrolase (decarboxylating) http://purl.obolibrary.org/obo/GO_0050529 GO:0050527 biolink:MolecularActivity poly(3-hydroxyoctanoate) depolymerase activity Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5. EC:3.1.1.76|MetaCyc:3.1.1.76-RXN go.json PHA depolymerase activity|PHO depolymerase activity|poly((R)-3-hydroxyoctanoate) hydrolase activity|poly((R)-hydroxyalkanoic acid) depolymerase activity|poly(3HO) depolymerase activity|poly(HA(MCL)) depolymerase activity|poly(HA) depolymerase activity|poly(HAMCL) depolymerase activity|poly[(R)-3-hydroxyoctanoate] hydrolase activity|poly[(R)-hydroxyalkanoic acid] depolymerase|poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity http://purl.obolibrary.org/obo/GO_0050527 GO:1990690 biolink:BiologicalProcess Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. go.json Golgi apparatus medial cisterna-derived vesicle fusion with Golgi apparatus cis cisterna membrane|medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane http://purl.obolibrary.org/obo/GO_1990690 GO:0050528 biolink:MolecularActivity acyloxyacyl hydrolase activity Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. EC:3.1.1.77|MetaCyc:3.1.1.77-RXN|RHEA:12032 go.json http://purl.obolibrary.org/obo/GO_0050528 GO:1990699 biolink:MolecularActivity palmitoleyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate. go.json http://purl.obolibrary.org/obo/GO_1990699 GO:0050532 biolink:MolecularActivity 2-phosphosulfolactate phosphatase activity Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate. EC:3.1.3.71|KEGG_REACTION:R05789|MetaCyc:R229-RXN|RHEA:23416 go.json (2R)-phosphosulfolactate phosphohydrolase activity|(R)-2-phospho-3-sulfolactate phosphohydrolase activity|2-phosphosulpholactate phosphatase activity|ComB phosphatase activity http://purl.obolibrary.org/obo/GO_0050532 GO:0050533 biolink:MolecularActivity 5-phytase activity Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate. EC:3.1.3.72|MetaCyc:3.1.3.72-RXN|RHEA:13001 go.json myo-inositol-hexakisphosphate 5-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050533 GO:0050530 biolink:MolecularActivity glucosylglycerol 3-phosphatase activity Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate. EC:3.1.3.69|KEGG_REACTION:R05791|MetaCyc:3.1.3.69-RXN|RHEA:22652 go.json 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity|StpA|salt tolerance protein A http://purl.obolibrary.org/obo/GO_0050530 GO:0050531 biolink:MolecularActivity mannosyl-3-phosphoglycerate phosphatase activity Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate. EC:3.1.3.70|KEGG_REACTION:R05790|MetaCyc:3.1.3.70-RXN|RHEA:19309 go.json alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050531 GO:0050536 biolink:MolecularActivity (S)-N-acetyl-1-phenylethylamine hydrolase activity Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine. EC:3.5.1.85|KEGG_REACTION:R07301|MetaCyc:3.5.1.85-RXN|RHEA:23952 go.json (S)-N-acetyl-1-phenylethylamine amidohydrolase activity|(S)-N-acetylphenylethylamine:H2O hydrolase activity http://purl.obolibrary.org/obo/GO_0050536 GO:0050537 biolink:MolecularActivity mandelamide amidase activity Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4. EC:3.5.1.86|KEGG_REACTION:R05783|MetaCyc:3.5.1.86-RXN|RHEA:22876 go.json Pseudomonas mandelamide hydrolase activity|mandelamide hydrolase activity http://purl.obolibrary.org/obo/GO_0050537 GO:0050534 biolink:MolecularActivity 3-deoxyoctulosonase activity Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide. EC:3.2.1.144|MetaCyc:RXN-12002 go.json 3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity|alpha-Kdo-ase activity http://purl.obolibrary.org/obo/GO_0050534 GO:0050535 biolink:MolecularActivity beta-primeverosidase activity Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol. EC:3.2.1.149|MetaCyc:3.2.1.149-RXN|RHEA:24480 go.json 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity|b-primeverosidase activity http://purl.obolibrary.org/obo/GO_0050535 GO:0050538 biolink:MolecularActivity N-carbamoyl-L-amino-acid hydrolase activity Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate. EC:3.5.1.87|MetaCyc:3.5.1.87-RXN|RHEA:17581 go.json L-carbamoylase activity|N-carbamoyl-L-amino acid amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050538 GO:0050539 biolink:MolecularActivity maleimide hydrolase activity Catalysis of the reaction: H2O + maleimide = H+ + maleamate. EC:3.5.2.16|KEGG_REACTION:R05781|MetaCyc:3.5.2.16-RXN|RHEA:24476 go.json cyclic imide hydrolase activity|cyclic-imide amidohydrolase (decyclicizing)|cyclic-imide amidohydrolase (decyclizing)|imidase activity http://purl.obolibrary.org/obo/GO_0050539 GO:0001700 biolink:BiologicalProcess embryonic development via the syncytial blastoderm The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0001700 GO:0001709 biolink:BiologicalProcess cell fate determination The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division. Wikipedia:Cell_fate_determination go.json http://purl.obolibrary.org/obo/GO_0001709 GO:0001705 biolink:BiologicalProcess ectoderm formation The formation of ectoderm during gastrulation. go.json http://purl.obolibrary.org/obo/GO_0001705 GO:0001706 biolink:BiologicalProcess endoderm formation The formation of the endoderm during gastrulation. go.json endoblast formation http://purl.obolibrary.org/obo/GO_0001706 GO:0001707 biolink:BiologicalProcess mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0001707 GO:0001708 biolink:BiologicalProcess cell fate specification The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate. go.json http://purl.obolibrary.org/obo/GO_0001708 GO:0001701 biolink:BiologicalProcess in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0001701 GO:0001702 biolink:BiologicalProcess gastrulation with mouth forming second A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. go.json deuterostomic gastrulation http://purl.obolibrary.org/obo/GO_0001702 GO:0001703 biolink:BiologicalProcess gastrulation with mouth forming first A gastrulation process in which the initial invagination becomes the mouth and the anus forms second. go.json protostomic gastrulation http://purl.obolibrary.org/obo/GO_0001703 GO:0001704 biolink:BiologicalProcess formation of primary germ layer The formation of the ectoderm, mesoderm and endoderm during gastrulation. go.json http://purl.obolibrary.org/obo/GO_0001704 GO:0001774 biolink:BiologicalProcess microglial cell activation The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0001774 GO:0098686 biolink:CellularComponent hippocampal mossy fiber to CA3 synapse One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. go.json http://purl.obolibrary.org/obo/GO_0098686 goslim_synapse GO:0001775 biolink:BiologicalProcess cell activation A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. go.json http://purl.obolibrary.org/obo/GO_0001775 goslim_pir GO:0098687 biolink:CellularComponent chromosomal region Any subdivision of a chromosome along its length. go.json chromosome region http://purl.obolibrary.org/obo/GO_0098687 GO:0001776 biolink:BiologicalProcess leukocyte homeostasis The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json immune cell homeostasis|leucocyte homeostasis http://purl.obolibrary.org/obo/GO_0001776 GO:0098684 biolink:CellularComponent photoreceptor ribbon synapse A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. go.json http://purl.obolibrary.org/obo/GO_0098684 goslim_synapse GO:0001777 biolink:BiologicalProcess T cell homeostatic proliferation The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. go.json T lymphocyte homeostatic proliferation|T-cell homeostatic proliferation|T-lymphocyte homeostatic proliferation|resting T cell proliferation|resting T-cell proliferation http://purl.obolibrary.org/obo/GO_0001777 GO:0098685 biolink:CellularComponent Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. go.json http://purl.obolibrary.org/obo/GO_0098685 goslim_synapse GO:0098682 biolink:CellularComponent arciform density An electron dense structure that anchors a synaptic ribbon to the presynaptic membrane. go.json http://purl.obolibrary.org/obo/GO_0098682 GO:0001770 biolink:BiologicalProcess establishment of natural killer cell polarity The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands. go.json NK cell polarization|establishment of NK cell polarity|natural killer cell polarization http://purl.obolibrary.org/obo/GO_0001770 GO:0098683 biolink:CellularComponent cochlear hair cell ribbon synapse A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density. go.json http://purl.obolibrary.org/obo/GO_0098683 goslim_synapse GO:0001771 biolink:BiologicalProcess immunological synapse formation The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. go.json formation of immunological synapse http://purl.obolibrary.org/obo/GO_0001771 GO:0098680 biolink:MolecularActivity template-free RNA nucleotidyltransferase Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template. go.json http://purl.obolibrary.org/obo/GO_0098680 GO:0001772 biolink:CellularComponent immunological synapse An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. Wikipedia:Immunological_synapse go.json c-SMAC|supramolecular activation cluster http://purl.obolibrary.org/obo/GO_0001772 GO:0001773 biolink:BiologicalProcess myeloid dendritic cell activation The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0001773 GO:0098681 biolink:CellularComponent synaptic ribbon A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical. go.json http://purl.obolibrary.org/obo/GO_0098681 GO:0060070 biolink:BiologicalProcess canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. go.json Wnt receptor signaling pathway through beta-catenin|Wnt receptor signaling pathway via beta-catenin|Wnt receptor signalling pathway through beta-catenin|canonical Wnt receptor signaling pathway|canonical Wnt-activated signaling pathway|frizzled-1 receptor signaling pathway http://purl.obolibrary.org/obo/GO_0060070 GO:0060071 biolink:BiologicalProcess Wnt signaling pathway, planar cell polarity pathway The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity. go.json PCP pathway|Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signalling pathway, planar cell polarity pathway|Wnt-JNK signaling pathway|Wnt-PCP signaling pathway|Wnt-activated signaling pathway, planar cell polarity pathway|non-canonical Wnt signaling pathway|planar cell polarity pathway http://purl.obolibrary.org/obo/GO_0060071 GO:0060072 biolink:MolecularActivity large conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. go.json BK KCa channel activity|BK calcium-activated potassium channel activity|BK channel activity|large conductance KCa channel activity http://purl.obolibrary.org/obo/GO_0060072 GO:0060073 biolink:BiologicalProcess micturition The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. Wikipedia:Urination go.json urination|urine voiding http://purl.obolibrary.org/obo/GO_0060073 GO:0060074 biolink:BiologicalProcess synapse maturation The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. go.json synaptic maturation http://purl.obolibrary.org/obo/GO_0060074 goslim_synapse GO:1902498 biolink:BiologicalProcess regulation of protein autoubiquitination Any process that modulates the frequency, rate or extent of protein autoubiquitination. go.json regulation of protein auto-ubiquitination|regulation of protein auto-ubiquitinylation|regulation of protein autoubiquitinylation|regulation of protein self-ubiquitination|regulation of protein self-ubiquitinylation http://purl.obolibrary.org/obo/GO_1902498 GO:1902499 biolink:BiologicalProcess positive regulation of protein autoubiquitination Any process that activates or increases the frequency, rate or extent of protein autoubiquitination. go.json activation of protein auto-ubiquitination|activation of protein auto-ubiquitinylation|activation of protein autoubiquitination|activation of protein autoubiquitinylation|activation of protein self-ubiquitination|activation of protein self-ubiquitinylation|positive regulation of protein auto-ubiquitination|positive regulation of protein auto-ubiquitinylation|positive regulation of protein autoubiquitinylation|positive regulation of protein self-ubiquitination|positive regulation of protein self-ubiquitinylation|up regulation of protein auto-ubiquitination|up regulation of protein auto-ubiquitinylation|up regulation of protein autoubiquitination|up regulation of protein autoubiquitinylation|up regulation of protein self-ubiquitination|up regulation of protein self-ubiquitinylation|up-regulation of protein auto-ubiquitination|up-regulation of protein auto-ubiquitinylation|up-regulation of protein autoubiquitination|up-regulation of protein autoubiquitinylation|up-regulation of protein self-ubiquitination|up-regulation of protein self-ubiquitinylation|upregulation of protein auto-ubiquitination|upregulation of protein auto-ubiquitinylation|upregulation of protein autoubiquitination|upregulation of protein autoubiquitinylation|upregulation of protein self-ubiquitination|upregulation of protein self-ubiquitinylation http://purl.obolibrary.org/obo/GO_1902499 GO:0060075 biolink:BiologicalProcess regulation of resting membrane potential Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized. go.json regulation of resting potential http://purl.obolibrary.org/obo/GO_0060075 GO:1902496 biolink:MolecularActivity obsolete protein binding involved in negative regulation of telomere maintenance via telomerase OBSOLETE. Any protein binding that is involved in negative regulation of telomere maintenance via telomerase. go.json protein binding involved in down regulation of telomere maintenance via telomerase activity|protein binding involved in down-regulation of telomere maintenance via telomerase activity|protein binding involved in downregulation of telomere maintenance via telomerase activity|protein binding involved in inhibition of telomere maintenance via telomerase True http://purl.obolibrary.org/obo/GO_1902496 GO:0060076 biolink:CellularComponent excitatory synapse A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. Wikipedia:Excitatory_synapse go.json http://purl.obolibrary.org/obo/GO_0060076 GO:0060077 biolink:CellularComponent inhibitory synapse A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. Wikipedia:Inhibitory_postsynaptic_potential go.json http://purl.obolibrary.org/obo/GO_0060077 GO:1902497 biolink:BiologicalProcess iron-sulfur cluster transmembrane transport A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json iron-sulfur cluster transport http://purl.obolibrary.org/obo/GO_1902497 GO:0060078 biolink:BiologicalProcess regulation of postsynaptic membrane potential Any process that modulates the potential difference across a post-synaptic membrane. go.json regulation of post-synaptic membrane potential http://purl.obolibrary.org/obo/GO_0060078 goslim_synapse GO:0060079 biolink:BiologicalProcess excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. go.json regulation of EPSP|regulation of excitatory post-synaptic membrane potential http://purl.obolibrary.org/obo/GO_0060079 GO:0001778 biolink:BiologicalProcess plasma membrane repair The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. go.json http://purl.obolibrary.org/obo/GO_0001778 GO:0001779 biolink:BiologicalProcess natural killer cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. go.json NK cell differentiation|natural killer cell development http://purl.obolibrary.org/obo/GO_0001779 GO:0098688 biolink:CellularComponent parallel fiber to Purkinje cell synapse An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. go.json http://purl.obolibrary.org/obo/GO_0098688 goslim_synapse GO:0098689 biolink:BiologicalProcess latency-replication decision The process by which a virus switches on its replication cycle in an infected cell. The process is typically controlled by a genetic swtich controlled by environmental factors such as cell type, cell shape, the availability of nutrients, superinfection or exposure of infected cells to UV or various chemical stimuli. VZ:3964 go.json Latency-replication switch|lytic switch|prophage induction|proviral induction|proviral switch|reactivation of latent virus http://purl.obolibrary.org/obo/GO_0098689 GO:0098697 biolink:MolecularActivity ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. go.json http://purl.obolibrary.org/obo/GO_0098697 goslim_synapse GO:0001785 biolink:MolecularActivity prostaglandin J receptor activity Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. go.json PGJ receptor activity|PGJ(2) receptor activity http://purl.obolibrary.org/obo/GO_0001785 GO:0098698 biolink:BiologicalProcess postsynaptic specialization assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane. go.json http://purl.obolibrary.org/obo/GO_0098698 goslim_synapse GO:0001786 biolink:MolecularActivity phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. go.json http://purl.obolibrary.org/obo/GO_0001786 GO:0001787 biolink:BiologicalProcess natural killer cell proliferation The expansion of a natural killer cell population by cell division. go.json NK cell proliferation http://purl.obolibrary.org/obo/GO_0001787 GO:0098695 biolink:MolecularActivity inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. go.json IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0098695 goslim_synapse GO:0001788 biolink:BiologicalProcess antibody-dependent cellular cytotoxicity Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity|Wikipedia:Antibody-dependent_cellular_cytotoxicity go.json ADCC|antibody dependent cell death|antibody dependent cell killing|antibody-dependent cell death|antibody-dependent cell killing|type VI hypersensitivity http://purl.obolibrary.org/obo/GO_0001788 GO:0098696 biolink:BiologicalProcess regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. go.json http://purl.obolibrary.org/obo/GO_0098696 goslim_synapse GO:0098693 biolink:BiologicalProcess regulation of synaptic vesicle cycle Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. go.json http://purl.obolibrary.org/obo/GO_0098693 goslim_synapse GO:0001781 biolink:BiologicalProcess neutrophil apoptotic process Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. go.json apoptosis of neutrophils|neutrophil apoptosis|neutrophil programmed cell death by apoptosis|programmed cell death of neutrophils by apoptosis|programmed cell death, neutrophils http://purl.obolibrary.org/obo/GO_0001781 GO:0001782 biolink:BiologicalProcess B cell homeostasis The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json B lymphocyte homeostasis|B-cell homeostasis|B-lymphocyte homeostasis http://purl.obolibrary.org/obo/GO_0001782 GO:0098694 biolink:BiologicalProcess regulation of synaptic vesicle budding from presynaptic endocytic zone membrane Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane. go.json http://purl.obolibrary.org/obo/GO_0098694 goslim_synapse GO:0001783 biolink:BiologicalProcess B cell apoptotic process Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. go.json B cell apoptosis|B cell programmed cell death by apoptosis|B lymphocyte apoptosis|B lymphocyte programmed cell death by apoptosis|B-cell apoptosis|B-cell programmed cell death by apoptosis|B-lymphocyte apoptosis|B-lymphocyte programmed cell death by apoptosis|apoptosis of B cells|apoptosis of B lymphocytes|apoptosis of B-cells|apoptosis of B-lymphocytes|programmed cell death of B cells by apoptosis|programmed cell death of B lymphocytes by apoptosis|programmed cell death of B-cells by apoptosis|programmed cell death of B-lymphocytes by apoptosis|programmed cell death, B cells|programmed cell death, B lymphocytes|programmed cell death, B-cells|programmed cell death, B-lymphocytes http://purl.obolibrary.org/obo/GO_0001783 GO:0098691 biolink:CellularComponent dopaminergic synapse A synapse that uses dopamine as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0098691 goslim_synapse GO:0001784 biolink:MolecularActivity phosphotyrosine residue binding Binding to a phosphorylated tyrosine residue within a protein. go.json phosphotyrosine binding http://purl.obolibrary.org/obo/GO_0001784 GO:0098692 biolink:CellularComponent noradrenergic synapse A synapse that uses noradrenaline as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0098692 GO:0060060 biolink:BiologicalProcess post-embryonic retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage. go.json http://purl.obolibrary.org/obo/GO_0060060 GO:0098690 biolink:CellularComponent glycinergic synapse A synapse that uses glycine as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0098690 goslim_synapse GO:0060061 biolink:BiologicalProcess Spemann organizer formation Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan. go.json Spemann's organizer formation|Spemann-Mangold organizer formation http://purl.obolibrary.org/obo/GO_0060061 GO:0060062 biolink:BiologicalProcess Spemann organizer formation at the dorsal lip of the blastopore Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan. go.json Spemann's organizer formation at the dorsal lip of the blastopore|Spemann-Mangold organizer formation at the dorsal lip of the blastopore http://purl.obolibrary.org/obo/GO_0060062 GO:0001780 biolink:BiologicalProcess neutrophil homeostasis The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0001780 GO:0060063 biolink:BiologicalProcess Spemann organizer formation at the embryonic shield Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan. go.json Spemann's organizer formation at the embryonic shield|Spemann-Mangold organizer formation at the embryonic shield http://purl.obolibrary.org/obo/GO_0060063 GO:0060064 biolink:BiologicalProcess Spemann organizer formation at the anterior end of the primitive streak Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan. go.json Spemann organizer formation in amniotes|Spemann's organizer formation at the anterior end of the primitive streak|Spemann-Mangold organizer formation at the anterior end of the primitive streak http://purl.obolibrary.org/obo/GO_0060064 GO:0060065 biolink:BiologicalProcess uterus development The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. go.json Mullerian tract development http://purl.obolibrary.org/obo/GO_0060065 GO:0060066 biolink:BiologicalProcess oviduct development The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. go.json Mullerian tract development|fallopian tube development http://purl.obolibrary.org/obo/GO_0060066 GO:0060067 biolink:BiologicalProcess cervix development The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure. go.json Mullerian tract development http://purl.obolibrary.org/obo/GO_0060067 GO:0060068 biolink:BiologicalProcess vagina development The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0060068 GO:0060069 biolink:BiologicalProcess Wnt signaling pathway, regulating spindle positioning The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle. go.json Wnt receptor signaling pathway, regulating spindle positioning|Wnt receptor signalling pathway, regulating spindle positioning|Wnt-activated signaling pathway, regulating spindle positioning|non-canonical Wnt signaling pathway http://purl.obolibrary.org/obo/GO_0060069 GO:0001789 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001789 GO:0098699 biolink:MolecularActivity structural constituent of presynaptic actin cytoskeleton The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0098699 goslim_synapse GO:0098664 biolink:BiologicalProcess G protein-coupled serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. go.json G-protein coupled serotonin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0098664 GO:0001752 biolink:BiologicalProcess compound eye photoreceptor fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. go.json http://purl.obolibrary.org/obo/GO_0001752 GO:0098665 biolink:CellularComponent serotonin receptor complex A protein complex that is capable of serotonin receptor activity. go.json 5-HT receptor complex|5-hydroxytryptamine receptor complex|5HT receptor complex http://purl.obolibrary.org/obo/GO_0098665 GO:0001753 biolink:BiologicalProcess obsolete adult eye photoreceptor development (sensu Drosophila) OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye. go.json adult eye photoreceptor development (sensu Drosophila) True http://purl.obolibrary.org/obo/GO_0001753 GO:0098662 biolink:BiologicalProcess inorganic cation transmembrane transport A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json divalent inorganic cation transport|inorganic cation membrane transport|monovalent inorganic cation transport|transmembrane inorganic cation transport http://purl.obolibrary.org/obo/GO_0098662 GO:0001754 biolink:BiologicalProcess eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. go.json http://purl.obolibrary.org/obo/GO_0001754 GO:0098663 biolink:MolecularActivity obsolete transmembrane transporter activity involved in import into cell OBSOLETE. Any transmembrane transporter activity that is involved in importing some substance into a cell. go.json True http://purl.obolibrary.org/obo/GO_0098663 GO:0001755 biolink:BiologicalProcess neural crest cell migration The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. go.json http://purl.obolibrary.org/obo/GO_0001755 GO:0098660 biolink:BiologicalProcess inorganic ion transmembrane transport The process in which an inorganic ion is transported across a membrane. go.json inorganic ion membrane transport|transmembrane inorganic ion transport http://purl.obolibrary.org/obo/GO_0098660 GO:0098661 biolink:BiologicalProcess inorganic anion transmembrane transport The process in which an inorganic anion is transported across a membrane. go.json inorganic anion membrane transport|transmembrane inorganic anion transport http://purl.obolibrary.org/obo/GO_0098661 GO:0060090 biolink:MolecularActivity molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. go.json binding, bridging|protein complex scaffold activity|protein-containing complex scaffold activity http://purl.obolibrary.org/obo/GO_0060090 goslim_drosophila|goslim_generic|goslim_pir|prokaryote_subset GO:0001750 biolink:CellularComponent photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. go.json http://purl.obolibrary.org/obo/GO_0001750 GO:0060091 biolink:CellularComponent kinocilium A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia. Wikipedia:Kinocilium go.json http://purl.obolibrary.org/obo/GO_0060091 GO:0001751 biolink:BiologicalProcess compound eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. go.json http://purl.obolibrary.org/obo/GO_0001751 GO:0060092 biolink:BiologicalProcess regulation of synaptic transmission, glycinergic Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. go.json http://purl.obolibrary.org/obo/GO_0060092 GO:0060093 biolink:BiologicalProcess negative regulation of synaptic transmission, glycinergic Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. go.json negative regulation of glycinergic synaptic transmission http://purl.obolibrary.org/obo/GO_0060093 GO:0060094 biolink:BiologicalProcess positive regulation of synaptic transmission, glycinergic Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. go.json positive regulation of glycinergic synaptic transmission http://purl.obolibrary.org/obo/GO_0060094 GO:0060095 biolink:BiologicalProcess zinc potentiation of synaptic transmission, glycinergic Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. go.json zinc potentiation of glycinergic synaptic transmission http://purl.obolibrary.org/obo/GO_0060095 GO:0060096 biolink:BiologicalProcess serotonin secretion, neurotransmission The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. go.json serotonin release, neurotransmission http://purl.obolibrary.org/obo/GO_0060096 GO:0060097 biolink:BiologicalProcess cytoskeletal rearrangement involved in phagocytosis, engulfment The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0060097 GO:0060098 biolink:BiologicalProcess membrane reorganization involved in phagocytosis, engulfment The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. go.json membrane reorganisation involved in phagocytosis, engulfment http://purl.obolibrary.org/obo/GO_0060098 GO:0060099 biolink:BiologicalProcess regulation of phagocytosis, engulfment Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0060099 GO:0001756 biolink:BiologicalProcess somitogenesis The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. Wikipedia:Somitogenesis go.json formation of mesodermal clusters http://purl.obolibrary.org/obo/GO_0001756 GO:0098668 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098668 GO:0098669 biolink:BiologicalProcess superinfection exclusion The process by which a preexisting viral infection prevents a secondary infection with the same or a closely related virus. Typically some aspect of viral entry is inhibited, but post entry mechanisms have also been documented. VZ:3971 go.json http://purl.obolibrary.org/obo/GO_0098669 GO:0001757 biolink:BiologicalProcess somite specification The process in which individual somites establish identity during embryogenesis. go.json http://purl.obolibrary.org/obo/GO_0001757 GO:0098666 biolink:CellularComponent G protein-coupled serotonin receptor complex A protein complex that is capable of G protein-coupled serotonin receptor activity. go.json G-protein coupled serotonin receptor complex http://purl.obolibrary.org/obo/GO_0098666 GO:0001758 biolink:MolecularActivity retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. EC:1.2.1.36|MetaCyc:RETINAL-DEHYDROGENASE-RXN|RHEA:16177|Reactome:R-HSA-5362522|Reactome:R-HSA-5696101 go.json cytosolic retinal dehydrogenase activity|retinal:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0001758 GO:0001759 biolink:BiologicalProcess organ induction The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. go.json induction of an organ http://purl.obolibrary.org/obo/GO_0001759 GO:0098667 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098667 GO:0098675 biolink:CellularComponent obsolete intrinsic component of neuronal dense core vesicle membrane OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to neuronal dense core granule membrane True http://purl.obolibrary.org/obo/GO_0098675 GO:0001763 biolink:BiologicalProcess morphogenesis of a branching structure The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. go.json branching morphogenesis http://purl.obolibrary.org/obo/GO_0001763 GO:0098676 biolink:BiologicalProcess modulation of host virulence by virus A process by which a virus improves the virulence of its host for that host's respective host. Common in but not limited to bacteriophages; also occurs in phage-bearing bacteria infecting plants or animals for example. Mechanisms include the expression of factors that modulate a bacterial adhesion to a host cell, spread through host tissues, production of exotoxins or provide protection against host immune defenses. go.json http://purl.obolibrary.org/obo/GO_0098676 GO:0001764 biolink:BiologicalProcess neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. Wikipedia:Neural_development#Neuron_migration|Wikipedia:Neuron_migration go.json neuron chemotaxis|neuron guidance|neuronal migration http://purl.obolibrary.org/obo/GO_0001764 GO:0001765 biolink:BiologicalProcess membrane raft assembly The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes. go.json lipid raft assembly|lipid raft formation|membrane raft formation http://purl.obolibrary.org/obo/GO_0001765 GO:0098673 biolink:BiologicalProcess inhibition of host DNA replication by virus Any process by which a virus inhibits DNA replication in its host cell. Some bacteriophages are known to do this, possibly as a way of increasing the pool of nucleotides available for virus replication. go.json http://purl.obolibrary.org/obo/GO_0098673 GO:0001766 biolink:BiologicalProcess membrane raft polarization The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. go.json lipid raft polarization|membrane polarization http://purl.obolibrary.org/obo/GO_0001766 GO:0098674 biolink:CellularComponent extrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098674 goslim_synapse GO:0098671 biolink:BiologicalProcess adhesion receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located. VZ:3943 go.json viral attachment to host adhesion receptor http://purl.obolibrary.org/obo/GO_0098671 GO:0001760 biolink:MolecularActivity aminocarboxymuconate-semialdehyde decarboxylase activity Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2. EC:4.1.1.45|KEGG_REACTION:R04323|MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN|RHEA:16557 go.json 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)|2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity|2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity|ACMSD activity|alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity|alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity|picolinic acid carboxylase activity|picolinic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0001760 GO:0098672 biolink:BiologicalProcess inhibition of host CRISPR-cas system by virus A process by which a virus inhibits the CRISPR-cas system of its host. VZ:3962 go.json CRISPR-cas system evasion by virus|anti-CRISPR|evasion by virus of CRISPR-cas system http://purl.obolibrary.org/obo/GO_0098672 GO:0001761 biolink:MolecularActivity beta-alanine transmembrane transporter activity Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid. go.json beta-alanine transporter activity http://purl.obolibrary.org/obo/GO_0001761 GO:0098670 biolink:BiologicalProcess entry receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration. VZ:3942 go.json viral attachment to host entry receptor http://purl.obolibrary.org/obo/GO_0098670 GO:0001762 biolink:BiologicalProcess beta-alanine transport The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0001762 GO:0060080 biolink:BiologicalProcess inhibitory postsynaptic potential A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. go.json IPSP|regulation of inhibitory post-synaptic membrane potential http://purl.obolibrary.org/obo/GO_0060080 GO:0060081 biolink:BiologicalProcess membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. go.json http://purl.obolibrary.org/obo/GO_0060081 GO:0060082 biolink:BiologicalProcess eye blink reflex The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing. go.json nictitating membrane reflex http://purl.obolibrary.org/obo/GO_0060082 GO:0060083 biolink:BiologicalProcess smooth muscle contraction involved in micturition The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. go.json smooth muscle contraction involved in urination|urinary bladder smooth muscle contraction involved in micturition http://purl.obolibrary.org/obo/GO_0060083 GO:0060084 biolink:BiologicalProcess synaptic transmission involved in micturition The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body. go.json synaptic transmission involved in urination http://purl.obolibrary.org/obo/GO_0060084 GO:0060085 biolink:BiologicalProcess smooth muscle relaxation of the bladder outlet A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body. go.json synaptic transmission involved in urination http://purl.obolibrary.org/obo/GO_0060085 GO:0060086 biolink:BiologicalProcess circadian temperature homeostasis Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours. go.json circadian regulation of body temperature|circadian thermoregulation http://purl.obolibrary.org/obo/GO_0060086 GO:0060087 biolink:BiologicalProcess relaxation of vascular associated smooth muscle A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity. go.json negative regulation of relaxation of vascular smooth muscle|positive regulation of relaxation of vascular smooth muscle|regulation of relaxation of vascular smooth muscle|relaxation of vascular smooth muscle|vascular smooth muscle relaxation http://purl.obolibrary.org/obo/GO_0060087 GO:0060088 biolink:BiologicalProcess auditory receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells. go.json auditory receptor cell stereocilium organisation|auditory receptor cell stereocilium organization and biogenesis http://purl.obolibrary.org/obo/GO_0060088 GO:0060089 biolink:MolecularActivity molecular transducer activity A compound molecular function in which an effector function is controlled by one or more regulatory components. go.json http://purl.obolibrary.org/obo/GO_0060089 gocheck_do_not_manually_annotate|goslim_generic|goslim_pir|prokaryote_subset GO:0001767 biolink:BiologicalProcess establishment of lymphocyte polarity The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. go.json lymphocyte polarization http://purl.obolibrary.org/obo/GO_0001767 GO:0098679 biolink:BiologicalProcess obsolete regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate catabloism. go.json regulation of carbohydrate catabolism by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0098679 GO:0001768 biolink:BiologicalProcess establishment of T cell polarity The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. go.json T cell polarization|T lymphocyte polarization|T-cell polarization|establishment of T lymphocyte polarity|establishment of T-cell polarity|establishment of T-lymphocyte polarity http://purl.obolibrary.org/obo/GO_0001768 GO:0001769 biolink:BiologicalProcess establishment of B cell polarity The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell. go.json B cell polarization|B lymphocyte polarization|B-cell polarization|establishment of B lymphocyte polarity|establishment of B-cell polarity|establishment of B-lymphocyte polarity http://purl.obolibrary.org/obo/GO_0001769 GO:0098677 biolink:BiologicalProcess virion maturation Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection. UniProtKB-KW:KW-0917|VZ:1946 go.json viral particle maturation|virus particle maturation http://purl.obolibrary.org/obo/GO_0098677 GO:0098678 biolink:BiologicalProcess viral tropism switching A process by which the range of hosts which a virus can bind and infect is changed. Examples include phages that switch between types of fibers via the action of a virally encoded invertase. VZ:4498 go.json http://purl.obolibrary.org/obo/GO_0098678 GO:0001730 biolink:MolecularActivity 2'-5'-oligoadenylate synthetase activity Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. EC:2.7.7.84|MetaCyc:RXN-13648|RHEA:34407|Reactome:R-HSA-8983680|Reactome:R-HSA-8985091|Reactome:R-HSA-8985104 go.json (2-5')oligo(A) synthetase activity|2'-5' oligoadenylate synthetase activity|2-5A synthetase activity|oligo-2',5'-adenylate synthetase activity http://purl.obolibrary.org/obo/GO_0001730 GO:0001731 biolink:BiologicalProcess formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA. go.json formation of translation pre-initiation complex|translation preinitiation complex assembly http://purl.obolibrary.org/obo/GO_0001731 GO:0001732 biolink:BiologicalProcess formation of cytoplasmic translation initiation complex Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. go.json cytoplasmic translation initiation complex assembly|formation of translation initiation complex|translation initiation complex assembly http://purl.obolibrary.org/obo/GO_0001732 GO:0001733 biolink:MolecularActivity galactosylceramide sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. EC:2.8.2.11|MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN|RHEA:20613 go.json 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity|3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity|GSase|cerebroside sulfotransferase activity|galactocerebroside sulfotransferase activity|galactolipid sulfotransferase activity|galactosylceramide sulphotransferase activity|glycolipid sulfotransferase activity|glycosphingolipid sulfotransferase activity http://purl.obolibrary.org/obo/GO_0001733 GO:0001738 biolink:BiologicalProcess morphogenesis of a polarized epithelium The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. go.json epithelial polarization http://purl.obolibrary.org/obo/GO_0001738 GO:0001739 biolink:CellularComponent sex chromatin Chromatin that is part of a sex chromosome. go.json http://purl.obolibrary.org/obo/GO_0001739 GO:0001734 biolink:MolecularActivity mRNA (N6-adenosine)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U. Reactome:R-HSA-72095 go.json http://purl.obolibrary.org/obo/GO_0001734 GO:0001735 biolink:MolecularActivity prenylcysteine oxidase activity Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. EC:1.8.3.5|MetaCyc:RXN-18932|RHEA:53892 go.json S-prenyl-L-cysteine:oxygen oxidoreductase activity|prenylcysteine lyase activity http://purl.obolibrary.org/obo/GO_0001735 GO:0001736 biolink:BiologicalProcess establishment of planar polarity Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates. go.json establishment of planar cell polarity http://purl.obolibrary.org/obo/GO_0001736 GO:0001737 biolink:BiologicalProcess establishment of imaginal disc-derived wing hair orientation Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction. go.json establishment of wing hair orientation http://purl.obolibrary.org/obo/GO_0001737 GO:0001741 biolink:CellularComponent XY body A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. go.json http://purl.obolibrary.org/obo/GO_0001741 GO:0001742 biolink:BiologicalProcess oenocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. go.json oenocyte cell differentiation http://purl.obolibrary.org/obo/GO_0001742 GO:0001743 biolink:BiologicalProcess lens placode formation The initial developmental process that will lead to the formation of an eye. go.json optic placode formation http://purl.obolibrary.org/obo/GO_0001743 GO:0001744 biolink:BiologicalProcess insect visual primordium formation Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system. go.json optic lobe and Bolwig's organ precursor formation|optic lobe placode formation http://purl.obolibrary.org/obo/GO_0001744 GO:0001740 biolink:CellularComponent Barr body A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. NIF_Subcellular:sao1571698684|Wikipedia:Barr_body go.json http://purl.obolibrary.org/obo/GO_0001740 GO:0001749 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001749 GO:0001745 biolink:BiologicalProcess compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. go.json insect-type retina morphogenesis http://purl.obolibrary.org/obo/GO_0001745 GO:0001746 biolink:BiologicalProcess Bolwig's organ morphogenesis The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. go.json http://purl.obolibrary.org/obo/GO_0001746 GO:0001747 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001747 GO:0001748 biolink:BiologicalProcess insect visual primordium development The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster. go.json optic lobe and Bolwig's organ precursor development|optic lobe placode development|optic placode development http://purl.obolibrary.org/obo/GO_0001748 GO:0001710 biolink:BiologicalProcess mesodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the mesoderm. go.json mesoderm cell fate commitment http://purl.obolibrary.org/obo/GO_0001710 GO:0001711 biolink:BiologicalProcess endodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the endoderm. go.json endoderm cell fate commitment http://purl.obolibrary.org/obo/GO_0001711 GO:0001716 biolink:MolecularActivity L-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. EC:1.4.3.2|MetaCyc:L-AMINO-ACID-OXIDASE-RXN|RHEA:13781|Reactome:R-HSA-2160492 go.json L-amino-acid:oxygen oxidoreductase (deaminating)|ophio-amino-acid oxidase activity http://purl.obolibrary.org/obo/GO_0001716 GO:0001717 biolink:BiologicalProcess conversion of seryl-tRNAsec to selenocys-tRNAsec The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine. go.json http://purl.obolibrary.org/obo/GO_0001717 GO:0001718 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001718 GO:0001719 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001719 GO:0001712 biolink:BiologicalProcess ectodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the ectoderm. go.json ectoderm cell fate commitment http://purl.obolibrary.org/obo/GO_0001712 GO:0001713 biolink:BiologicalProcess ectodermal cell fate determination The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json ectoderm cell fate determination http://purl.obolibrary.org/obo/GO_0001713 GO:0001714 biolink:BiologicalProcess endodermal cell fate specification The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json endoderm cell fate specification http://purl.obolibrary.org/obo/GO_0001714 GO:0001715 biolink:BiologicalProcess ectodermal cell fate specification The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json ectoderm cell fate specification http://purl.obolibrary.org/obo/GO_0001715 GO:0001720 biolink:BiologicalProcess conversion of lysyl-tRNA to pyrrolysyl-tRNA The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate). go.json http://purl.obolibrary.org/obo/GO_0001720 GO:0001721 biolink:CellularComponent obsolete intermediate filament associated protein OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks. go.json IFAP|intermediate filament associated protein True http://purl.obolibrary.org/obo/GO_0001721 GO:0001722 biolink:CellularComponent obsolete type I intermediate filament associated protein OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates. go.json type I intermediate filament associated protein True http://purl.obolibrary.org/obo/GO_0001722 GO:0001727 biolink:MolecularActivity lipid kinase activity Catalysis of the phosphorylation of a simple or complex lipid. go.json http://purl.obolibrary.org/obo/GO_0001727 GO:0001728 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001728 GO:0001729 biolink:MolecularActivity ceramide kinase activity Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. EC:2.7.1.138|MetaCyc:CERAMIDE-KINASE-RXN|RHEA:17929|Reactome:R-HSA-1638845 go.json ATP:ceramide 1-phosphotransferase activity|acylsphingosine kinase activity http://purl.obolibrary.org/obo/GO_0001729 GO:0001723 biolink:CellularComponent obsolete type II intermediate filament associated protein OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks. go.json type II intermediate filament associated protein True http://purl.obolibrary.org/obo/GO_0001723 GO:0001724 biolink:CellularComponent obsolete type III intermediate filament associated protein OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane. go.json type III intermediate filament associated protein True http://purl.obolibrary.org/obo/GO_0001724 GO:0001725 biolink:CellularComponent stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. go.json actin cable|stress fibre http://purl.obolibrary.org/obo/GO_0001725 GO:0001726 biolink:CellularComponent ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. go.json membrane ruffle http://purl.obolibrary.org/obo/GO_0001726 GO:0050664 biolink:MolecularActivity oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. EC:1.6.3.- go.json oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0050664 GO:0050665 biolink:BiologicalProcess hydrogen peroxide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. go.json H2O2 biosynthetic process|hydrogen peroxide anabolism|hydrogen peroxide biosynthesis|hydrogen peroxide formation|hydrogen peroxide generation|hydrogen peroxide synthesis http://purl.obolibrary.org/obo/GO_0050665 GO:0050662 biolink:MolecularActivity obsolete coenzyme binding OBSOLETE. Binding to a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. go.json True http://purl.obolibrary.org/obo/GO_0050662 GO:0050663 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050663 GO:1902418 biolink:BiologicalProcess (+)-abscisic acid D-glucopyranosyl ester transmembrane transport The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane. go.json ABA-GE transmembrane transport|abscisic acid glucosyl ester transmembrane transport http://purl.obolibrary.org/obo/GO_1902418 GO:0050668 biolink:BiologicalProcess positive regulation of homocysteine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. go.json activation of homocysteine metabolic process|positive regulation of Hcy metabolic process|positive regulation of Hcy metabolism|positive regulation of homocysteine metabolism|stimulation of homocysteine metabolic process|up regulation of homocysteine metabolic process|up-regulation of homocysteine metabolic process|upregulation of homocysteine metabolic process http://purl.obolibrary.org/obo/GO_0050668 GO:0050669 biolink:BiologicalProcess negative regulation of homocysteine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. go.json down regulation of homocysteine metabolic process|down-regulation of homocysteine metabolic process|downregulation of homocysteine metabolic process|inhibition of homocysteine metabolic process|negative regulation of Hcy metabolic process|negative regulation of Hcy metabolism|negative regulation of homocysteine metabolism http://purl.obolibrary.org/obo/GO_0050669 GO:1902419 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902419 GO:1902416 biolink:BiologicalProcess positive regulation of mRNA binding Any process that activates or increases the frequency, rate or extent of mRNA binding. go.json activation of mRNA binding|up regulation of mRNA binding|up-regulation of mRNA binding|upregulation of mRNA binding http://purl.obolibrary.org/obo/GO_1902416 gocheck_do_not_annotate GO:0050666 biolink:BiologicalProcess regulation of homocysteine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. go.json regulation of Hcy metabolic process|regulation of Hcy metabolism|regulation of homocysteine metabolism http://purl.obolibrary.org/obo/GO_0050666 GO:0050667 biolink:BiologicalProcess homocysteine metabolic process The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. go.json Hcy metabolic process|Hcy metabolism|homocysteine metabolism http://purl.obolibrary.org/obo/GO_0050667 GO:1902417 biolink:MolecularActivity (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other. go.json ABA-GE transmembrane transporter activity|abscisic acid glucosyl ester transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1902417 GO:1902414 biolink:BiologicalProcess protein localization to cell junction A process in which a protein is transported to, or maintained in, a location within a cell junction. go.json protein localisation in cell junction|protein localisation to cell junction|protein localization in cell junction http://purl.obolibrary.org/obo/GO_1902414 GO:1902415 biolink:BiologicalProcess regulation of mRNA binding Any process that modulates the frequency, rate or extent of mRNA binding. go.json http://purl.obolibrary.org/obo/GO_1902415 gocheck_do_not_annotate GO:1902412 biolink:BiologicalProcess regulation of mitotic cytokinesis Any process that modulates the frequency, rate or extent of mitotic cytokinesis. go.json regulation of cytokinesis after mitosis http://purl.obolibrary.org/obo/GO_1902412 GO:1902413 biolink:BiologicalProcess negative regulation of mitotic cytokinesis Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis. go.json down regulation of cytokinesis after mitosis|down regulation of mitotic cytokinesis|down-regulation of cytokinesis after mitosis|down-regulation of mitotic cytokinesis|downregulation of cytokinesis after mitosis|downregulation of mitotic cytokinesis|inhibition of cytokinesis after mitosis|inhibition of mitotic cytokinesis|negative regulation of cytokinesis after mitosis http://purl.obolibrary.org/obo/GO_1902413 GO:1902410 biolink:BiologicalProcess mitotic cytokinetic process Any cytokinetic process that is involved in mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_1902410 GO:1902411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902411 GO:0035023 biolink:BiologicalProcess regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0035023 GO:0035024 biolink:BiologicalProcess negative regulation of Rho protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. go.json down regulation of Rho protein signal transduction|down-regulation of Rho protein signal transduction|downregulation of Rho protein signal transduction|inhibition of Rho protein signal transduction http://purl.obolibrary.org/obo/GO_0035024 GO:0035025 biolink:BiologicalProcess positive regulation of Rho protein signal transduction Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. go.json activation of Rho protein signal transduction|stimulation of Rho protein signal transduction|up regulation of Rho protein signal transduction|up-regulation of Rho protein signal transduction|upregulation of Rho protein signal transduction http://purl.obolibrary.org/obo/GO_0035025 GO:0035026 biolink:BiologicalProcess leading edge cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0035026 GO:0035027 biolink:BiologicalProcess leading edge cell fate commitment The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0035027 GO:0035028 biolink:BiologicalProcess leading edge cell fate determination The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0035028 GO:0098608 biolink:MolecularActivity methylselenol demethylase activity Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH. Reactome:R-HSA-2408530 go.json http://purl.obolibrary.org/obo/GO_0098608 GO:0035029 biolink:BiologicalProcess dorsal closure, leading edge cell fate commitment The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis. go.json http://purl.obolibrary.org/obo/GO_0035029 GO:0098609 biolink:BiologicalProcess cell-cell adhesion The attachment of one cell to another cell via adhesion molecules. go.json single organismal cell-cell adhesion http://purl.obolibrary.org/obo/GO_0098609 GO:0098606 biolink:MolecularActivity selenocystathionine gamma-lyase activity Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid. RHEA:31151|Reactome:R-HSA-2408543 go.json http://purl.obolibrary.org/obo/GO_0098606 GO:0098607 biolink:MolecularActivity methylselenocysteine deselenhydrase activity Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol. Reactome:R-HSA-2408539 go.json http://purl.obolibrary.org/obo/GO_0098607 GO:0098604 biolink:MolecularActivity adenosylselenohomocysteinase activity Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine. Reactome:R-HSA-2408532 go.json http://purl.obolibrary.org/obo/GO_0098604 GO:0098605 biolink:MolecularActivity selenocystathionine beta-synthase activity Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O. Reactome:R-HSA-2408559 go.json http://purl.obolibrary.org/obo/GO_0098605 GO:0098602 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098602 GO:0050660 biolink:MolecularActivity flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. go.json FAD or FADH2 binding|flavine-adenine dinucleotide binding http://purl.obolibrary.org/obo/GO_0050660 GO:0098603 biolink:MolecularActivity selenol Se-methyltransferase activity Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine. Reactome:R-HSA-2408544 go.json http://purl.obolibrary.org/obo/GO_0098603 GO:0050661 biolink:MolecularActivity NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. go.json NADP or NADPH binding|NADP+ or NADPH binding|nicotinamide adenine dinucleotide phosphate binding http://purl.obolibrary.org/obo/GO_0050661 GO:0035020 biolink:BiologicalProcess regulation of Rac protein signal transduction Any process that modulates the frequency, rate or extent of Rac protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0035020 GO:0098600 biolink:MolecularActivity selenomethionine gamma-lyase activity Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid. Reactome:R-HSA-2408537 go.json http://purl.obolibrary.org/obo/GO_0098600 GO:0035021 biolink:BiologicalProcess negative regulation of Rac protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction. go.json down regulation of Rac protein signal transduction|down-regulation of Rac protein signal transduction|downregulation of Rac protein signal transduction|inhibition of Rac protein signal transduction http://purl.obolibrary.org/obo/GO_0035021 GO:0035022 biolink:BiologicalProcess positive regulation of Rac protein signal transduction Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. go.json activation of Rac protein signal transduction|stimulation of Rac protein signal transduction|up regulation of Rac protein signal transduction|up-regulation of Rac protein signal transduction|upregulation of Rac protein signal transduction http://purl.obolibrary.org/obo/GO_0035022 GO:0098601 biolink:MolecularActivity selenomethionine adenosyltransferase activity Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine. RHEA:31211|Reactome:R-HSA-2408551 go.json http://purl.obolibrary.org/obo/GO_0098601 GO:0050675 biolink:BiologicalProcess regulation of urothelial cell proliferation Any process that modulates the frequency, rate or extent of urothelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0050675 GO:0098610 biolink:BiologicalProcess adhesion between unicellular organisms The attachment of two unicellular organisms to each other. go.json adhesion between unicellular organisms via cell-wall interaction|multi-organismal cell-cell adhesion http://purl.obolibrary.org/obo/GO_0098610 GO:0050676 biolink:BiologicalProcess negative regulation of urothelial cell proliferation Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation. go.json down regulation of urothelial cell proliferation|down-regulation of urothelial cell proliferation|downregulation of urothelial cell proliferation|inhibition of urothelial cell proliferation http://purl.obolibrary.org/obo/GO_0050676 GO:0050673 biolink:BiologicalProcess epithelial cell proliferation The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. go.json http://purl.obolibrary.org/obo/GO_0050673 GO:0050674 biolink:BiologicalProcess urothelial cell proliferation The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. go.json http://purl.obolibrary.org/obo/GO_0050674 GO:1902429 biolink:BiologicalProcess positive regulation of water channel activity Any process that activates or increases the frequency, rate or extent of water channel activity. go.json activation of aquaporin|activation of water channel activity|aquaporin activation|positive regulation of aquaporin|up regulation of aquaporin|up regulation of water channel activity|up-regulation of aquaporin|up-regulation of water channel activity|upregulation of aquaporin|upregulation of water channel activity http://purl.obolibrary.org/obo/GO_1902429 gocheck_do_not_annotate GO:0050679 biolink:BiologicalProcess positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation. go.json activation of epithelial cell proliferation|stimulation of epithelial cell proliferation|up regulation of epithelial cell proliferation|up-regulation of epithelial cell proliferation|upregulation of epithelial cell proliferation http://purl.obolibrary.org/obo/GO_0050679 GO:0050677 biolink:BiologicalProcess positive regulation of urothelial cell proliferation Any process that activates or increases the rate or extent of urothelial cell proliferation. go.json activation of urothelial cell proliferation|stimulation of urothelial cell proliferation|up regulation of urothelial cell proliferation|up-regulation of urothelial cell proliferation|upregulation of urothelial cell proliferation http://purl.obolibrary.org/obo/GO_0050677 GO:1902427 biolink:BiologicalProcess regulation of water channel activity Any process that modulates the frequency, rate or extent of water channel activity. go.json regulation of aquaporin|regulation of aquaporin permeability http://purl.obolibrary.org/obo/GO_1902427 gocheck_do_not_annotate GO:1902428 biolink:BiologicalProcess negative regulation of water channel activity Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity. go.json down regulation of aquaporin|down regulation of water channel activity|down-regulation of aquaporin|down-regulation of water channel activity|downregulation of aquaporin|downregulation of water channel activity|inhibition of aquaporin|inhibition of water channel activity|negative regulation of aquaporin http://purl.obolibrary.org/obo/GO_1902428 gocheck_do_not_annotate GO:0050678 biolink:BiologicalProcess regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0050678 GO:1902425 biolink:BiologicalProcess positive regulation of attachment of mitotic spindle microtubules to kinetochore Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. go.json activation of attachment of spindle microtubules to kinetochore during mitosis|activation of attachment of spindle microtubules to kinetochore involved in mitosis|activation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|activation of attachment of spindle microtubules to mitotic chromosome|activation of mitotic bipolar attachment|positive regulation of attachment of spindle microtubules to kinetochore during mitosis|positive regulation of attachment of spindle microtubules to kinetochore involved in mitosis|positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of attachment of spindle microtubules to mitotic chromosome|positive regulation of mitotic bipolar attachment|up regulation of attachment of spindle microtubules to kinetochore during mitosis|up regulation of attachment of spindle microtubules to kinetochore involved in mitosis|up regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|up regulation of attachment of spindle microtubules to mitotic chromosome|up regulation of mitotic bipolar attachment|up-regulation of attachment of spindle microtubules to kinetochore during mitosis|up-regulation of attachment of spindle microtubules to kinetochore involved in mitosis|up-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|up-regulation of attachment of spindle microtubules to mitotic chromosome|up-regulation of mitotic bipolar attachment|upregulation of attachment of spindle microtubules to kinetochore during mitosis|upregulation of attachment of spindle microtubules to kinetochore involved in mitosis|upregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|upregulation of attachment of spindle microtubules to mitotic chromosome|upregulation of mitotic bipolar attachment http://purl.obolibrary.org/obo/GO_1902425 GO:1902426 biolink:BiologicalProcess deactivation of mitotic spindle assembly checkpoint A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint. go.json down regulation of Mad2-dependent checkpoint|down regulation of mitotic cell cycle spindle assembly checkpoint|down regulation of mitotic spindle assembly checkpoint|down-regulation of Mad2-dependent checkpoint|down-regulation of mitotic cell cycle spindle assembly checkpoint|down-regulation of mitotic spindle assembly checkpoint|downregulation of Mad2-dependent checkpoint|downregulation of mitotic cell cycle spindle assembly checkpoint|downregulation of mitotic spindle assembly checkpoint|inhibition of Mad2-dependent checkpoint|inhibition of mitotic cell cycle spindle assembly checkpoint|inhibition of mitotic spindle assembly checkpoint|mitotic spindle assembly checkpoint silencing|mitotic spindle assembly deactivation|negative regulation of Mad2-dependent checkpoint|negative regulation of mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_1902426 GO:1902423 biolink:BiologicalProcess regulation of attachment of mitotic spindle microtubules to kinetochore Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. go.json regulation of attachment of spindle microtubules to kinetochore during mitosis|regulation of attachment of spindle microtubules to kinetochore involved in mitosis|regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|regulation of attachment of spindle microtubules to mitotic chromosome|regulation of mitotic attachment of spindle microtubules to kinetochore|regulation of mitotic bipolar attachment http://purl.obolibrary.org/obo/GO_1902423 GO:1902424 biolink:BiologicalProcess negative regulation of attachment of mitotic spindle microtubules to kinetochore Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. go.json down regulation of attachment of spindle microtubules to kinetochore during mitosis|down regulation of attachment of spindle microtubules to kinetochore involved in mitosis|down regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|down regulation of attachment of spindle microtubules to mitotic chromosome|down regulation of mitotic bipolar attachment|down-regulation of attachment of spindle microtubules to kinetochore during mitosis|down-regulation of attachment of spindle microtubules to kinetochore involved in mitosis|down-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|down-regulation of attachment of spindle microtubules to mitotic chromosome|down-regulation of mitotic bipolar attachment|downregulation of attachment of spindle microtubules to kinetochore during mitosis|downregulation of attachment of spindle microtubules to kinetochore involved in mitosis|downregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|downregulation of attachment of spindle microtubules to mitotic chromosome|downregulation of mitotic bipolar attachment|inhibition of attachment of spindle microtubules to kinetochore during mitosis|inhibition of attachment of spindle microtubules to kinetochore involved in mitosis|inhibition of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|inhibition of attachment of spindle microtubules to mitotic chromosome|inhibition of mitotic bipolar attachment|negative regulation of attachment of spindle microtubules to kinetochore during mitosis|negative regulation of attachment of spindle microtubules to kinetochore involved in mitosis|negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|negative regulation of attachment of spindle microtubules to mitotic chromosome|negative regulation of mitotic attachment of spindle microtubules to kinetochore|negative regulation of mitotic bipolar attachment http://purl.obolibrary.org/obo/GO_1902424 GO:1902421 biolink:BiologicalProcess hydrogen metabolic process The chemical reactions and pathways involving H2 (dihydrogen). go.json H2 metabolism|dihydrogen metabolism|molecular hydrogen metabolism http://purl.obolibrary.org/obo/GO_1902421 GO:1902422 biolink:BiologicalProcess hydrogen biosynthetic process The chemical reactions and pathways resulting in the formation of H2 (dihydrogen). go.json H2 biosynthesis|dihydrogen synthesis|hydrogen anabolism|hydrogen biosynthesis|hydrogen formation|hydrogen generation|hydrogen production|hydrogen synthesis|molecular hydrogen biosynthesis http://purl.obolibrary.org/obo/GO_1902422 GO:1902420 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902420 GO:0035012 biolink:CellularComponent obsolete polytene chromosome, telomeric region OBSOLETE. The terminal region of a polytene chromosome. go.json True http://purl.obolibrary.org/obo/GO_0035012 GO:0035013 biolink:MolecularActivity myosuppressin receptor activity Combining with the peptide myosuppressin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0035013 GO:0035014 biolink:MolecularActivity phosphatidylinositol 3-kinase regulator activity Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. go.json PI3K regulator activity|phosphoinositide 3-kinase regulator activity http://purl.obolibrary.org/obo/GO_0035014 GO:0035015 biolink:BiologicalProcess elongation of arista core The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. go.json http://purl.obolibrary.org/obo/GO_0035015 GO:0035016 biolink:BiologicalProcess elongation of arista lateral The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. go.json http://purl.obolibrary.org/obo/GO_0035016 GO:0035017 biolink:BiologicalProcess cuticle pattern formation The regionalization process that gives rise to the patterns of cell differentiation in the cuticle. go.json http://purl.obolibrary.org/obo/GO_0035017 GO:0098619 biolink:MolecularActivity selenocysteine-tRNA ligase activity Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate. Reactome:R-HSA-2408526 go.json http://purl.obolibrary.org/obo/GO_0098619 GO:0035018 biolink:BiologicalProcess adult chitin-based cuticle pattern formation The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster. go.json adult cuticle pattern formation http://purl.obolibrary.org/obo/GO_0035018 GO:0035019 biolink:BiologicalProcess somatic stem cell population maintenance Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. go.json http://purl.obolibrary.org/obo/GO_0035019 GO:0098617 biolink:MolecularActivity adenylylselenate kinase activity Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate. Reactome:R-HSA-2408540 go.json http://purl.obolibrary.org/obo/GO_0098617 GO:0098618 biolink:MolecularActivity selenomethionine-tRNA ligase activity Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met). Reactome:R-HSA-2408546 go.json http://purl.obolibrary.org/obo/GO_0098618 GO:0098615 biolink:MolecularActivity dimethyl selenide methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium. Reactome:R-HSA-2408554 go.json http://purl.obolibrary.org/obo/GO_0098615 GO:0098616 biolink:MolecularActivity selenate adenylyltransferase (ATP) activity Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate. Reactome:R-HSA-2408525 go.json http://purl.obolibrary.org/obo/GO_0098616 GO:0098613 biolink:MolecularActivity methaneselenol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide. Reactome:R-HSA-2408541 go.json http://purl.obolibrary.org/obo/GO_0098613 GO:0050671 biolink:BiologicalProcess positive regulation of lymphocyte proliferation Any process that activates or increases the rate or extent of lymphocyte proliferation. go.json activation of lymphocyte proliferation|stimulation of lymphocyte proliferation|up regulation of lymphocyte proliferation|up-regulation of lymphocyte proliferation|upregulation of lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0050671 GO:0050672 biolink:BiologicalProcess negative regulation of lymphocyte proliferation Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. go.json down regulation of lymphocyte proliferation|down-regulation of lymphocyte proliferation|downregulation of lymphocyte proliferation|inhibition of lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0050672 GO:0098614 biolink:MolecularActivity hydrogen selenide methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol. Reactome:R-HSA-2408536 go.json http://purl.obolibrary.org/obo/GO_0098614 GO:0098611 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098611 GO:0035010 biolink:BiologicalProcess encapsulation of foreign target Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization. go.json http://purl.obolibrary.org/obo/GO_0035010 GO:0050670 biolink:BiologicalProcess regulation of lymphocyte proliferation Any process that modulates the frequency, rate or extent of lymphocyte proliferation. go.json http://purl.obolibrary.org/obo/GO_0050670 GO:0035011 biolink:BiologicalProcess melanotic encapsulation of foreign target Formation of a multilayered, melanized sheath of cells around a foreign invader. go.json http://purl.obolibrary.org/obo/GO_0035011 GO:0098612 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098612 GO:0050686 biolink:BiologicalProcess negative regulation of mRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing. go.json down regulation of mRNA processing|down-regulation of mRNA processing|downregulation of mRNA processing|inhibition of mRNA processing http://purl.obolibrary.org/obo/GO_0050686 GO:0050687 biolink:BiologicalProcess negative regulation of defense response to virus Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. go.json down regulation of antiviral response|down-regulation of antiviral response|downregulation of antiviral response|inhibition of antiviral response|negative regulation of antiviral response http://purl.obolibrary.org/obo/GO_0050687 GO:0050684 biolink:BiologicalProcess regulation of mRNA processing Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. go.json http://purl.obolibrary.org/obo/GO_0050684 GO:0050685 biolink:BiologicalProcess positive regulation of mRNA processing Any process that activates or increases the frequency, rate or extent of mRNA processing. go.json activation of mRNA processing|stimulation of mRNA processing|up regulation of mRNA processing|up-regulation of mRNA processing|upregulation of mRNA processing http://purl.obolibrary.org/obo/GO_0050685 GO:1902438 biolink:BiologicalProcess response to vanadate(3-) Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus. go.json http://purl.obolibrary.org/obo/GO_1902438 GO:0050688 biolink:BiologicalProcess regulation of defense response to virus Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. go.json regulation of antiviral response http://purl.obolibrary.org/obo/GO_0050688 GO:1902439 biolink:BiologicalProcess cellular response to vanadate(3-) Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus. go.json http://purl.obolibrary.org/obo/GO_1902439 GO:0050689 biolink:BiologicalProcess negative regulation of defense response to virus by host Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation of antiviral response by host|down-regulation of antiviral response by host|downregulation of antiviral response by host|inhibition of antiviral response by host|negative regulation by host of antiviral response|negative regulation of antiviral response by host http://purl.obolibrary.org/obo/GO_0050689 GO:1902436 biolink:BiologicalProcess negative regulation of male mating behavior Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior. go.json down regulation of male mating behavior|down-regulation of male mating behavior|downregulation of male mating behavior|inhibition of male mating behavior http://purl.obolibrary.org/obo/GO_1902436 GO:0035009 biolink:BiologicalProcess negative regulation of melanization defense response Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection. go.json down regulation of melanization defense response|down-regulation of melanization defense response|downregulation of melanization defense response|inhibition of melanization defense response|negative regulation of melanization defence response http://purl.obolibrary.org/obo/GO_0035009 GO:1902437 biolink:BiologicalProcess positive regulation of male mating behavior Any process that activates or increases the frequency, rate or extent of male mating behavior. go.json activation of male mating behavior|up regulation of male mating behavior|up-regulation of male mating behavior|upregulation of male mating behavior http://purl.obolibrary.org/obo/GO_1902437 GO:1902434 biolink:BiologicalProcess sulfate import across plasma membrane The directed movement of sulfate from outside of a cell, across the plasma membrane and into the cytosol. go.json sulfate import into cell|sulphate import into cell http://purl.obolibrary.org/obo/GO_1902434 GO:1902435 biolink:BiologicalProcess regulation of male mating behavior Any process that modulates the frequency, rate or extent of male mating behavior. go.json http://purl.obolibrary.org/obo/GO_1902435 GO:1902432 biolink:BiologicalProcess protein localization to division septum A process in which a protein is transported to, or maintained in, a location within a division septum. go.json protein localisation in division septum|protein localisation to division septum|protein localization in division septum http://purl.obolibrary.org/obo/GO_1902432 GO:1902433 biolink:BiologicalProcess positive regulation of water channel activity involved in maintenance of lens transparency Any positive regulation of water channel activity that is involved in maintenance of lens transparency. go.json activation of aquaporin involved in maintenance of lens transparency|activation of aquaporin involved in maintenance of ocular lens transparency|activation of aquaporin involved in preservation of lens transparency|activation of water channel activity involved in maintenance of lens transparency|activation of water channel activity involved in maintenance of ocular lens transparency|activation of water channel activity involved in preservation of lens transparency|aquaporin activation involved in maintenance of lens transparency|aquaporin activation involved in maintenance of ocular lens transparency|aquaporin activation involved in preservation of lens transparency|positive regulation of aquaporin involved in maintenance of lens transparency|positive regulation of aquaporin involved in maintenance of ocular lens transparency|positive regulation of aquaporin involved in preservation of lens transparency|positive regulation of water channel activity involved in maintenance of ocular lens transparency|positive regulation of water channel activity involved in preservation of lens transparency|up regulation of aquaporin involved in maintenance of lens transparency|up regulation of aquaporin involved in maintenance of ocular lens transparency|up regulation of aquaporin involved in preservation of lens transparency|up regulation of water channel activity involved in maintenance of lens transparency|up regulation of water channel activity involved in maintenance of ocular lens transparency|up regulation of water channel activity involved in preservation of lens transparency|up-regulation of aquaporin involved in maintenance of lens transparency|up-regulation of aquaporin involved in maintenance of ocular lens transparency|up-regulation of aquaporin involved in preservation of lens transparency|up-regulation of water channel activity involved in maintenance of lens transparency|up-regulation of water channel activity involved in maintenance of ocular lens transparency|up-regulation of water channel activity involved in preservation of lens transparency|upregulation of aquaporin involved in maintenance of lens transparency|upregulation of aquaporin involved in maintenance of ocular lens transparency|upregulation of aquaporin involved in preservation of lens transparency|upregulation of water channel activity involved in maintenance of lens transparency|upregulation of water channel activity involved in maintenance of ocular lens transparency|upregulation of water channel activity involved in preservation of lens transparency http://purl.obolibrary.org/obo/GO_1902433 gocheck_do_not_annotate GO:1902430 biolink:BiologicalProcess negative regulation of amyloid-beta formation Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation. go.json down regulation of beta-amyloid formation|down-regulation of beta-amyloid formation|downregulation of beta-amyloid formation|inhibition of beta-amyloid formation|negative regulation of beta-amyloid formation http://purl.obolibrary.org/obo/GO_1902430 GO:0060010 biolink:BiologicalProcess Sertoli cell fate commitment The process in which the cellular identity of Sertoli cells is acquired and determined. go.json http://purl.obolibrary.org/obo/GO_0060010 GO:1902431 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902431 GO:0060011 biolink:BiologicalProcess Sertoli cell proliferation The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. go.json http://purl.obolibrary.org/obo/GO_0060011 GO:0035001 biolink:BiologicalProcess dorsal trunk growth, open tracheal system Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system. go.json dorsal trunk growth http://purl.obolibrary.org/obo/GO_0035001 GO:0060012 biolink:BiologicalProcess synaptic transmission, glycinergic The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json glycinergic synaptic transmission http://purl.obolibrary.org/obo/GO_0060012 GO:1902440 biolink:BiologicalProcess protein localization to mitotic spindle pole body A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body. go.json establishment of protein localization to mitotic spindle pole body|protein localisation in mitotic spindle pole body|protein localisation to mitotic spindle pole body|protein localization in mitotic spindle pole body http://purl.obolibrary.org/obo/GO_1902440 GO:0060013 biolink:BiologicalProcess righting reflex A reflex process in which an animal immediately tries to turn over after being placed in a supine position. go.json righting response http://purl.obolibrary.org/obo/GO_0060013 GO:0035002 biolink:BiologicalProcess liquid clearance, open tracheal system The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system. go.json tracheal liquid clearance http://purl.obolibrary.org/obo/GO_0035002 GO:0035003 biolink:CellularComponent subapical complex The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells. go.json SAC http://purl.obolibrary.org/obo/GO_0035003 GO:0060014 biolink:BiologicalProcess granulosa cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals. go.json http://purl.obolibrary.org/obo/GO_0060014 GO:0035004 biolink:MolecularActivity obsolete phosphatidylinositol 3-kinase activity OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. go.json phosphoinositide 3-kinase activity True http://purl.obolibrary.org/obo/GO_0035004 GO:0060015 biolink:BiologicalProcess granulosa cell fate commitment The cell fate commitment of precursor cells that will become granulosa cells. go.json http://purl.obolibrary.org/obo/GO_0060015 GO:0035005 biolink:MolecularActivity 1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+. EC:2.7.1.154|KEGG_REACTION:R05795|MetaCyc:2.7.1.154-RXN|RHEA:18373|Reactome:R-HSA-1675928|Reactome:R-HSA-1676109|Reactome:R-HSA-1676206|Reactome:R-HSA-8868072 go.json ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity|C2-domain-containing phosphoinositide 3-kinase activity|phosphatidylinositol 3-kinase activity, class I|phosphatidylinositol 3-kinase activity, class II|phosphatidylinositol 3-kinase, class I, catalyst activity|phosphatidylinositol-4-phosphate 3-kinase activity|type II phosphoinositide 3-kinase activity http://purl.obolibrary.org/obo/GO_0035005 GO:0060016 biolink:BiologicalProcess granulosa cell development The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate. go.json http://purl.obolibrary.org/obo/GO_0060016 GO:0035006 biolink:BiologicalProcess melanization defense response The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin. go.json melanization defence response http://purl.obolibrary.org/obo/GO_0035006 GO:0060017 biolink:BiologicalProcess parathyroid gland development The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone. go.json http://purl.obolibrary.org/obo/GO_0060017 GO:0035007 biolink:BiologicalProcess regulation of melanization defense response Any process that affects the rate, extent or location of the melanization defense response during injury or invasion. go.json regulation of melanization defence response http://purl.obolibrary.org/obo/GO_0035007 GO:0060018 biolink:BiologicalProcess astrocyte fate commitment The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte. go.json http://purl.obolibrary.org/obo/GO_0060018 GO:0035008 biolink:BiologicalProcess positive regulation of melanization defense response Any process that increases the rate or extent of the melanization defense response during injury or invasion. go.json activation of melanization defense response|positive regulation of melanization defence response|stimulation of melanization defense response|up regulation of melanization defense response|up-regulation of melanization defense response|upregulation of melanization defense response http://purl.obolibrary.org/obo/GO_0035008 GO:0060019 biolink:BiologicalProcess radial glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0060019 GO:0050682 biolink:MolecularActivity AF-2 domain binding Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. go.json http://purl.obolibrary.org/obo/GO_0050682 GO:0050683 biolink:MolecularActivity AF-1 domain binding Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. go.json http://purl.obolibrary.org/obo/GO_0050683 GO:0050680 biolink:BiologicalProcess negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. go.json down regulation of epithelial cell proliferation|down-regulation of epithelial cell proliferation|downregulation of epithelial cell proliferation|inhibition of epithelial cell proliferation http://purl.obolibrary.org/obo/GO_0050680 GO:0050681 biolink:MolecularActivity nuclear androgen receptor binding Binding to a nuclear androgen receptor. go.json AR binding|androgen receptor binding http://purl.obolibrary.org/obo/GO_0050681 GO:0035000 biolink:CellularComponent oligosaccharyltransferase III complex An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes. go.json OSTCIII http://purl.obolibrary.org/obo/GO_0035000 GO:0050697 biolink:MolecularActivity 1,1,2-trichloroethene reductive dehalogenase activity Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene. MetaCyc:TCEREDCHLOR-RXN|UM-BBD_enzymeID:e0271 go.json 1,1,2-trichloroethylene reductive dehalogenase activity|TCE-reductive dehalogenase activity http://purl.obolibrary.org/obo/GO_0050697 GO:0050698 biolink:MolecularActivity proteoglycan sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans. go.json proteoglycan sulfate transfer|proteoglycan sulphotransferase activity http://purl.obolibrary.org/obo/GO_0050698 GO:0050695 biolink:MolecularActivity benzoylformate decarboxylase activity Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. EC:4.1.1.7|MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN|RHEA:23368|UM-BBD_reactionID:r1049 go.json benzoylformate carboxy-lyase (benzaldehyde-forming)|benzoylformate carboxy-lyase activity|phenylglyoxylate decarboxylase activity http://purl.obolibrary.org/obo/GO_0050695 GO:0050696 biolink:BiologicalProcess trichloroethylene catabolic process The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent. go.json trichloroethene catabolic process|trichloroethene catabolism|trichloroethylene breakdown|trichloroethylene catabolism|trichloroethylene degradation http://purl.obolibrary.org/obo/GO_0050696 GO:0050699 biolink:MolecularActivity WW domain binding Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. go.json http://purl.obolibrary.org/obo/GO_0050699 GO:1902449 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902449 GO:1902447 biolink:BiologicalProcess negative regulation of shade avoidance Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance. go.json down regulation of shade avoidance|down-regulation of shade avoidance|downregulation of shade avoidance|inhibition of shade avoidance http://purl.obolibrary.org/obo/GO_1902447 GO:1902448 biolink:BiologicalProcess positive regulation of shade avoidance Any process that activates or increases the frequency, rate or extent of shade avoidance. go.json activation of shade avoidance|up regulation of shade avoidance|up-regulation of shade avoidance|upregulation of shade avoidance http://purl.obolibrary.org/obo/GO_1902448 GO:1902445 biolink:BiologicalProcess regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death. go.json regulation of transport across mitochondrial membrane involved in programmed necrotic cell death http://purl.obolibrary.org/obo/GO_1902445 GO:1902446 biolink:BiologicalProcess regulation of shade avoidance Any process that modulates the frequency, rate or extent of shade avoidance. go.json http://purl.obolibrary.org/obo/GO_1902446 GO:1902443 biolink:BiologicalProcess negative regulation of ripoptosome assembly involved in necroptotic process Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process. go.json down regulation of ripoptosome assembly involved in necroptosis|down-regulation of ripoptosome assembly involved in necroptosis|downregulation of ripoptosome assembly involved in necroptosis|inhibition of ripoptosome assembly involved in necroptosis|negative regulation of ripoptosome assembly involved in necroptosis http://purl.obolibrary.org/obo/GO_1902443 GO:1902444 biolink:MolecularActivity riboflavin binding Binding to riboflavin. go.json http://purl.obolibrary.org/obo/GO_1902444 GO:1902441 biolink:BiologicalProcess protein localization to meiotic spindle pole body A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body. go.json establishment of protein localization to meiotic spindle pole body|protein localisation in meiotic spindle pole body|protein localisation to meiotic spindle pole body|protein localization in meiotic spindle pole body|protein location to meiotic spindle pole body http://purl.obolibrary.org/obo/GO_1902441 GO:1902442 biolink:BiologicalProcess regulation of ripoptosome assembly involved in necroptotic process Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process. go.json regulation of ripoptosome assembly involved in necroptosis http://purl.obolibrary.org/obo/GO_1902442 GO:0060001 biolink:MolecularActivity minus-end directed microfilament motor activity A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. go.json minus-end directed actin filament motor activity|minus-end directed actin-filament motor activity|pointed-end directed actin-filament motor activity http://purl.obolibrary.org/obo/GO_0060001 GO:1902450 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902450 GO:0060002 biolink:MolecularActivity plus-end directed microfilament motor activity A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. go.json barbed-end directed actin-filament motor activity|plus-end directed actin filament motor activity|plus-end directed actin-filament motor activity http://purl.obolibrary.org/obo/GO_0060002 GO:1902451 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902451 GO:0060003 biolink:BiologicalProcess copper ion export The directed movement of copper ions out of a cell or organelle. go.json copper export http://purl.obolibrary.org/obo/GO_0060003 GO:0060004 biolink:BiologicalProcess reflex An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. Wikipedia:Reflex go.json http://purl.obolibrary.org/obo/GO_0060004 GO:0060005 biolink:BiologicalProcess vestibular reflex A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. go.json http://purl.obolibrary.org/obo/GO_0060005 GO:0060006 biolink:BiologicalProcess angular vestibuloocular reflex A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. go.json http://purl.obolibrary.org/obo/GO_0060006 GO:0060007 biolink:BiologicalProcess linear vestibuloocular reflex A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. go.json http://purl.obolibrary.org/obo/GO_0060007 GO:0060008 biolink:BiologicalProcess Sertoli cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. go.json http://purl.obolibrary.org/obo/GO_0060008 GO:0060009 biolink:BiologicalProcess Sertoli cell development The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. go.json http://purl.obolibrary.org/obo/GO_0060009 GO:0050690 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050690 GO:0050693 biolink:MolecularActivity LBD domain binding Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. go.json ligand binding domain binding http://purl.obolibrary.org/obo/GO_0050693 GO:0050694 biolink:MolecularActivity galactose 3-O-sulfotransferase activity Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. go.json Gal-3-O-sulfotransferase activity|galactose 3-O-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0050694 GO:0050691 biolink:BiologicalProcess regulation of defense response to virus by host Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. go.json host regulation of antiviral response|regulation by host of antiviral response|regulation of antiviral response by host http://purl.obolibrary.org/obo/GO_0050691 GO:0050692 biolink:MolecularActivity DNA binding domain binding Binding to a protein's DNA binding domain (DBD). go.json DBD binding http://purl.obolibrary.org/obo/GO_0050692 GO:0001697 biolink:BiologicalProcess histamine-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP. go.json http://purl.obolibrary.org/obo/GO_0001697 GO:0098642 biolink:CellularComponent network-forming collagen trimer A collagen trimer that forms networks. go.json http://purl.obolibrary.org/obo/GO_0098642 GO:0098643 biolink:CellularComponent banded collagen fibril A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). go.json http://purl.obolibrary.org/obo/GO_0098643 GO:0001698 biolink:BiologicalProcess gastrin-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of gastrin with its receptor. go.json http://purl.obolibrary.org/obo/GO_0001698 GO:0098640 biolink:MolecularActivity integrin binding involved in cell-matrix adhesion Any integrin binding that occurs as part of the process of cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_0098640 GO:0001699 biolink:BiologicalProcess acetylcholine-induced gastric acid secretion The regulated release of gastric acid by parietal cells in response to acetylcholine. go.json http://purl.obolibrary.org/obo/GO_0001699 GO:0098641 biolink:MolecularActivity cadherin binding involved in cell-cell adhesion Any cadherin binding that occurs as part of the process of cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0098641 GO:0001693 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001693 GO:0001694 biolink:BiologicalProcess histamine biosynthetic process The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json histamine anabolism|histamine biosynthesis|histamine formation|histamine synthesis http://purl.obolibrary.org/obo/GO_0001694 GO:0001695 biolink:BiologicalProcess histamine catabolic process The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json histamine breakdown|histamine catabolism|histamine degradation http://purl.obolibrary.org/obo/GO_0001695 GO:0001696 biolink:BiologicalProcess gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. go.json hydrochloric acid secretion http://purl.obolibrary.org/obo/GO_0001696 GO:1902458 biolink:BiologicalProcess positive regulation of stomatal opening Any process that activates or increases the frequency, rate or extent of stomatal opening. go.json activation of stomatal opening|up regulation of stomatal opening|up-regulation of stomatal opening|upregulation of stomatal opening http://purl.obolibrary.org/obo/GO_1902458 GO:0001690 biolink:CellularComponent obsolete cytoplasmic dynein light chain OBSOLETE. (Was not defined before being made obsolete). go.json cytoplasmic dynein light chain True http://purl.obolibrary.org/obo/GO_0001690 GO:1902459 biolink:BiologicalProcess positive regulation of stem cell population maintenance Any process that activates or increases the frequency, rate or extent of stem cell population maintenance. go.json activation of maintenance of pluripotency|activation of stem cell maintenance|positive regulation of maintenance of pluripotency|up regulation of maintenance of pluripotency|up regulation of stem cell maintenance|up-regulation of maintenance of pluripotency|up-regulation of stem cell maintenance|upregulation of maintenance of pluripotency|upregulation of stem cell maintenance http://purl.obolibrary.org/obo/GO_1902459 GO:1902456 biolink:BiologicalProcess regulation of stomatal opening Any process that modulates the frequency, rate or extent of stomatal opening. go.json http://purl.obolibrary.org/obo/GO_1902456 GO:0001691 biolink:MolecularActivity pseudophosphatase activity Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues. go.json http://purl.obolibrary.org/obo/GO_0001691 GO:1902457 biolink:BiologicalProcess negative regulation of stomatal opening Any process that stops, prevents or reduces the frequency, rate or extent of stomatal opening. go.json down regulation of stomatal opening|down-regulation of stomatal opening|downregulation of stomatal opening|inhibition of stomatal opening http://purl.obolibrary.org/obo/GO_1902457 GO:0001692 biolink:BiologicalProcess histamine metabolic process The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json histamine metabolism http://purl.obolibrary.org/obo/GO_0001692 GO:0060030 biolink:BiologicalProcess dorsal convergence The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement. go.json http://purl.obolibrary.org/obo/GO_0060030 GO:1902454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902454 GO:1902455 biolink:BiologicalProcess negative regulation of stem cell population maintenance Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance. go.json down regulation of maintenance of pluripotency|down regulation of stem cell maintenance|down-regulation of maintenance of pluripotency|down-regulation of stem cell maintenance|downregulation of maintenance of pluripotency|downregulation of stem cell maintenance|inhibition of maintenance of pluripotency|inhibition of stem cell maintenance|negative regulation of maintenance of pluripotency http://purl.obolibrary.org/obo/GO_1902455 GO:0060031 biolink:BiologicalProcess mediolateral intercalation The interdigitation of cells along the mediolateral axis during gastrulation. go.json http://purl.obolibrary.org/obo/GO_0060031 GO:0060032 biolink:BiologicalProcess notochord regression The developmental process in which the stucture of the notochord is destroyed in an embryo. go.json http://purl.obolibrary.org/obo/GO_0060032 GO:1902452 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902452 GO:0060033 biolink:BiologicalProcess anatomical structure regression The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. go.json histolysis|tissue death http://purl.obolibrary.org/obo/GO_0060033 GO:1902453 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902453 GO:1902461 biolink:BiologicalProcess negative regulation of mesenchymal stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation. go.json down regulation of MSC proliferation|down regulation of mesenchymal stem cell proliferation|down-regulation of MSC proliferation|down-regulation of mesenchymal stem cell proliferation|downregulation of MSC proliferation|downregulation of mesenchymal stem cell proliferation|inhibition of MSC proliferation|inhibition of mesenchymal stem cell proliferation|negative regulation of MSC proliferation http://purl.obolibrary.org/obo/GO_1902461 GO:0060034 biolink:BiologicalProcess notochord cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate. go.json http://purl.obolibrary.org/obo/GO_0060034 GO:0060035 biolink:BiologicalProcess notochord cell development The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0060035 GO:1902462 biolink:BiologicalProcess positive regulation of mesenchymal stem cell proliferation Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation. go.json activation of MSC proliferation|activation of mesenchymal stem cell proliferation|positive regulation of MSC proliferation|up regulation of MSC proliferation|up regulation of mesenchymal stem cell proliferation|up-regulation of MSC proliferation|up-regulation of mesenchymal stem cell proliferation|upregulation of MSC proliferation|upregulation of mesenchymal stem cell proliferation http://purl.obolibrary.org/obo/GO_1902462 GO:0060036 biolink:BiologicalProcess notochord cell vacuolation The assembly and arrangement of a vacuole within a cell of the notochord. go.json http://purl.obolibrary.org/obo/GO_0060036 GO:1902460 biolink:BiologicalProcess regulation of mesenchymal stem cell proliferation Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation. go.json regulation of MSC proliferation http://purl.obolibrary.org/obo/GO_1902460 GO:0060037 biolink:BiologicalProcess pharyngeal system development The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. go.json http://purl.obolibrary.org/obo/GO_0060037 GO:0060038 biolink:BiologicalProcess cardiac muscle cell proliferation The expansion of a cardiac muscle cell population by cell division. go.json cardiac myocyte proliferation|cardiomyocyte proliferation|heart muscle cell proliferation http://purl.obolibrary.org/obo/GO_0060038 GO:0060039 biolink:BiologicalProcess pericardium development The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. go.json http://purl.obolibrary.org/obo/GO_0060039 GO:0098648 biolink:CellularComponent collagen anchoring fibril A specialised collagen fibril that functions as an anchor, binding to other collagen structures. go.json http://purl.obolibrary.org/obo/GO_0098648 GO:0098649 biolink:BiologicalProcess obsolete response to peptidyl-dipeptidase A inhibitor OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus. go.json response to ACE inhibitor|response to angiotensin-converting enzyme inhibitor True http://purl.obolibrary.org/obo/GO_0098649 GO:0098646 biolink:CellularComponent collagen sheet A protein complex that consists of collagen triple helices associated to form a sheet-like network. go.json collagen hexagonal network http://purl.obolibrary.org/obo/GO_0098646 GO:0098647 biolink:CellularComponent collagen beaded filament A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure. go.json beads on a string http://purl.obolibrary.org/obo/GO_0098647 GO:0098644 biolink:CellularComponent complex of collagen trimers A complex of collagen trimers such as a fibril or collagen network. go.json Supramolecular aggregate of collagen|Supramolecular collagen assembly http://purl.obolibrary.org/obo/GO_0098644 GO:0098645 biolink:CellularComponent collagen network A supramolecular complex that consists of collagen triple helices associated to form a network. go.json http://purl.obolibrary.org/obo/GO_0098645 GO:0098653 biolink:BiologicalProcess centromere clustering The process by which centromeres/kinetochores become localized to clusters. go.json kinetochore clustering http://purl.obolibrary.org/obo/GO_0098653 GO:0098654 biolink:CellularComponent CENP-A recruiting complex A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere. go.json MIS18 complex http://purl.obolibrary.org/obo/GO_0098654 GO:0098651 biolink:CellularComponent basement membrane collagen trimer Any collagen timer that is part of a basement membrane. go.json http://purl.obolibrary.org/obo/GO_0098651 GO:0098652 biolink:CellularComponent collagen type VII anchoring fibril An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis. go.json http://purl.obolibrary.org/obo/GO_0098652 GO:0098650 biolink:MolecularActivity peptidyl-proline 4-dioxygenase binding Binding to a peptidyl-proline 4-dioxygenase. go.json http://purl.obolibrary.org/obo/GO_0098650 GO:1902469 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902469 GO:1902467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902467 GO:1902468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902468 GO:1902465 biolink:BiologicalProcess negative regulation of histone H3-K27 trimethylation Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation. go.json down regulation of histone H3-K27 trimethylation|down-regulation of histone H3-K27 trimethylation|downregulation of histone H3-K27 trimethylation|inhibition of histone H3-K27 trimethylation http://purl.obolibrary.org/obo/GO_1902465 GO:1902466 biolink:BiologicalProcess positive regulation of histone H3-K27 trimethylation Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation. go.json activation of histone H3-K27 trimethylation|up regulation of histone H3-K27 trimethylation|up-regulation of histone H3-K27 trimethylation|upregulation of histone H3-K27 trimethylation http://purl.obolibrary.org/obo/GO_1902466 GO:0060020 biolink:BiologicalProcess Bergmann glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0060020 GO:0060021 biolink:BiologicalProcess roof of mouth development The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. go.json palatum development http://purl.obolibrary.org/obo/GO_0060021 GO:1902463 biolink:BiologicalProcess protein localization to cell leading edge A process in which a protein is transported to, or maintained in, a location within a cell leading edge. go.json protein localisation in cell leading edge|protein localisation to cell leading edge|protein localization in cell leading edge http://purl.obolibrary.org/obo/GO_1902463 GO:1902464 biolink:BiologicalProcess regulation of histone H3-K27 trimethylation Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation. go.json http://purl.obolibrary.org/obo/GO_1902464 GO:0060022 biolink:BiologicalProcess hard palate development The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes. go.json palatum durum development http://purl.obolibrary.org/obo/GO_0060022 GO:0060023 biolink:BiologicalProcess soft palate development The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate. go.json palatum molle development|velum palatum development http://purl.obolibrary.org/obo/GO_0060023 GO:1902472 biolink:BiologicalProcess regulation of mitotic cytokinesis, division site positioning Any process that modulates the frequency, rate or extent of mitotic cytokinesis, division site positioning. go.json regulation of mitotic cytokinesis, site selection http://purl.obolibrary.org/obo/GO_1902472 GO:0060024 biolink:BiologicalProcess rhythmic synaptic transmission Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit. go.json http://purl.obolibrary.org/obo/GO_0060024 GO:1902473 biolink:BiologicalProcess regulation of protein localization to synapse Any process that modulates the frequency, rate or extent of protein localization to synapse. go.json regulation of protein localisation to synapse http://purl.obolibrary.org/obo/GO_1902473 GO:1902470 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902470 GO:0060025 biolink:BiologicalProcess regulation of synaptic activity Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell. go.json http://purl.obolibrary.org/obo/GO_0060025 GO:1902471 biolink:BiologicalProcess obsolete regulation of mitotic actomyosin contractile ring localization OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring localization. go.json True http://purl.obolibrary.org/obo/GO_1902471 GO:0060026 biolink:BiologicalProcess convergent extension The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. Wikipedia:Convergent_extension go.json http://purl.obolibrary.org/obo/GO_0060026 GO:0060027 biolink:BiologicalProcess convergent extension involved in gastrulation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. go.json http://purl.obolibrary.org/obo/GO_0060027 GO:0060028 biolink:BiologicalProcess convergent extension involved in axis elongation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism. go.json http://purl.obolibrary.org/obo/GO_0060028 GO:0060029 biolink:BiologicalProcess convergent extension involved in organogenesis The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ. go.json http://purl.obolibrary.org/obo/GO_0060029 GO:0098659 biolink:BiologicalProcess inorganic cation import across plasma membrane The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol. go.json inorganic cation import into cell http://purl.obolibrary.org/obo/GO_0098659 GO:0098657 biolink:BiologicalProcess import into cell The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. go.json uptake http://purl.obolibrary.org/obo/GO_0098657 GO:0098658 biolink:BiologicalProcess inorganic anion import across plasma membrane The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol. go.json inorganic anion import into cell http://purl.obolibrary.org/obo/GO_0098658 GO:0098655 biolink:BiologicalProcess monoatomic cation transmembrane transport The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. go.json ATP hydrolysis coupled cation transmembrane transport|cation transmembrane transport http://purl.obolibrary.org/obo/GO_0098655 GO:0098656 biolink:BiologicalProcess monoatomic anion transmembrane transport The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. go.json ATP hydrolysis coupled anion transmembrane transport|anion transmembrane transport http://purl.obolibrary.org/obo/GO_0098656 GO:0098620 biolink:MolecularActivity seryl-selenocysteinyl-tRNA kinase activity Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP. Reactome:R-HSA-2408507 go.json http://purl.obolibrary.org/obo/GO_0098620 GO:0001675 biolink:BiologicalProcess acrosome assembly The formation of the acrosome from the spermatid Golgi. go.json acrosome formation http://purl.obolibrary.org/obo/GO_0001675 GO:0098621 biolink:MolecularActivity O-phosphoseryl-tRNA(Sec) selenium transferase activity Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid. EC:2.9.1.2|RHEA:25041|Reactome:R-HSA-2408555 go.json O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase|O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase|SepSecS|phosphoseryl-selenocysteinyl-tRNA selenium transferase activity http://purl.obolibrary.org/obo/GO_0098621 GO:0001676 biolink:BiologicalProcess long-chain fatty acid metabolic process The chemical reactions and pathways involving a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json long-chain fatty acid metabolism http://purl.obolibrary.org/obo/GO_0001676 GO:0001677 biolink:BiologicalProcess formation of translation initiation ternary complex Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). go.json translation initiation ternary complex assembly http://purl.obolibrary.org/obo/GO_0001677 GO:0001678 biolink:BiologicalProcess intracellular glucose homeostasis A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. go.json cell glucose homeostasis|cellular glucose homeostasis http://purl.obolibrary.org/obo/GO_0001678 GO:0001671 biolink:MolecularActivity ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity. Reactome:R-HSA-5251955|Reactome:R-HSA-5251959 go.json ATPase stimulator activity http://purl.obolibrary.org/obo/GO_0001671 GO:0001672 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001672 GO:0001673 biolink:CellularComponent male germ cell nucleus The nucleus of a male germ cell, a reproductive cell in males. go.json male germ-cell nucleus http://purl.obolibrary.org/obo/GO_0001673 GO:0001674 biolink:CellularComponent female germ cell nucleus The nucleus of the female germ cell, a reproductive cell in females. go.json female germ-cell nucleus http://purl.obolibrary.org/obo/GO_0001674 GO:0060050 biolink:BiologicalProcess positive regulation of protein glycosylation Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. go.json positive regulation of protein amino acid glycosylation http://purl.obolibrary.org/obo/GO_0060050 GO:1902478 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902478 GO:0060051 biolink:BiologicalProcess negative regulation of protein glycosylation Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. go.json negative regulation of protein amino acid glycosylation http://purl.obolibrary.org/obo/GO_0060051 GO:0001670 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001670 GO:1902479 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902479 GO:1902476 biolink:BiologicalProcess chloride transmembrane transport The process in which chloride is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902476 GO:0060052 biolink:BiologicalProcess neurofilament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins. go.json neurofilament cytoskeleton organisation|neurofilament cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0060052 GO:1902477 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902477 GO:0060053 biolink:CellularComponent neurofilament cytoskeleton Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons. go.json http://purl.obolibrary.org/obo/GO_0060053 GO:1902474 biolink:BiologicalProcess positive regulation of protein localization to synapse Any process that activates or increases the frequency, rate or extent of protein localization to synapse. go.json activation of protein localisation to synapse|activation of protein localization to synapse|positive regulation of protein localisation to synapse|up regulation of protein localisation to synapse|up regulation of protein localization to synapse|up-regulation of protein localisation to synapse|up-regulation of protein localization to synapse|upregulation of protein localisation to synapse|upregulation of protein localization to synapse http://purl.obolibrary.org/obo/GO_1902474 GO:0060054 biolink:BiologicalProcess positive regulation of epithelial cell proliferation involved in wound healing Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury. go.json http://purl.obolibrary.org/obo/GO_0060054 GO:0060055 biolink:BiologicalProcess angiogenesis involved in wound healing Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. go.json http://purl.obolibrary.org/obo/GO_0060055 GO:1902475 biolink:BiologicalProcess L-alpha-amino acid transmembrane transport The directed movement of L-alpha-amino acid across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902475 GO:1902483 biolink:BiologicalProcess cytotoxic T cell pyroptotic process Any pyroptotic process in a cytotoxic T cell. go.json cytotoxic T cell apoptosis|cytotoxic T cell apoptotic process|cytotoxic T lymphocyte apoptosis|cytotoxic T lymphocyte apoptotic process|cytotoxic T-cell apoptosis|cytotoxic T-cell apoptotic process|cytotoxic T-lymphocyte apoptosis|cytotoxic T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1902483 GO:0060056 biolink:BiologicalProcess mammary gland involution The tissue remodeling that removes differentiated mammary epithelia during weaning. go.json http://purl.obolibrary.org/obo/GO_0060056 GO:1902484 biolink:BiologicalProcess Sertoli cell apoptotic process Any apoptotic process in a Sertoli cell. go.json Sertoli cell apoptosis http://purl.obolibrary.org/obo/GO_1902484 GO:0060057 biolink:BiologicalProcess apoptotic process involved in mammary gland involution Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death. go.json apoptosis involved in mammary gland involution http://purl.obolibrary.org/obo/GO_0060057 GO:0060058 biolink:BiologicalProcess positive regulation of apoptotic process involved in mammary gland involution Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution. go.json positive regulation of apoptosis involved in mammary gland involution http://purl.obolibrary.org/obo/GO_0060058 GO:1902481 biolink:BiologicalProcess gamma-tubulin complex assembly The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex. go.json gamma-tubulin complex formation http://purl.obolibrary.org/obo/GO_1902481 GO:1902482 biolink:BiologicalProcess regulatory T cell apoptotic process Any apoptotic process in a regulatory T cell. go.json regulatory T cell apoptosis|regulatory T lymphocyte apoptosis|regulatory T lymphocyte apoptotic process|regulatory T-cell apoptosis|regulatory T-cell apoptotic process|regulatory T-lymphocyte apoptosis|regulatory T-lymphocyte apoptotic process http://purl.obolibrary.org/obo/GO_1902482 GO:0060059 biolink:BiologicalProcess embryonic retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage. go.json http://purl.obolibrary.org/obo/GO_0060059 GO:1902480 biolink:BiologicalProcess protein localization to mitotic spindle A process in which a protein is transported to, or maintained in, a location within a mitotic spindle. go.json protein localisation in mitotic spindle|protein localisation to mitotic spindle|protein localization in mitotic spindle http://purl.obolibrary.org/obo/GO_1902480 GO:0098628 biolink:BiologicalProcess peptidyl-N-phospho-arginine dephosphorylation The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine. go.json http://purl.obolibrary.org/obo/GO_0098628 gocheck_do_not_annotate GO:0098629 biolink:BiologicalProcess trans-Golgi network membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane. go.json http://purl.obolibrary.org/obo/GO_0098629 GO:0098626 biolink:MolecularActivity methylseleninic acid reductase activity Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O. Reactome:R-HSA-5263616 go.json http://purl.obolibrary.org/obo/GO_0098626 GO:0098627 biolink:MolecularActivity protein arginine phosphatase activity Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate. EC:3.9.1.2|RHEA:43380 go.json http://purl.obolibrary.org/obo/GO_0098627 GO:0098624 biolink:MolecularActivity 3'-phosphoadenylylselenate reductase activity Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+. Reactome:R-HSA-2408548 go.json PAPSe reductase activity http://purl.obolibrary.org/obo/GO_0098624 GO:0001679 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001679 GO:0098625 biolink:MolecularActivity methylselenol reductase activity Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O. Reactome:R-HSA-5263614 go.json http://purl.obolibrary.org/obo/GO_0098625 GO:0098622 biolink:MolecularActivity selenodiglutathione-disulfide reductase (NADP) activity Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+. RHEA:34927|Reactome:R-HSA-2408542 go.json selenodiglutathione-disulfide reductase activity http://purl.obolibrary.org/obo/GO_0098622 GO:0098623 biolink:MolecularActivity selenite reductase activity Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O. Reactome:R-HSA-2408558 go.json http://purl.obolibrary.org/obo/GO_0098623 GO:0098631 biolink:MolecularActivity cell adhesion mediator activity The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell. go.json cell adhesion molecule|protein binding involved in cell adhesion http://purl.obolibrary.org/obo/GO_0098631 goslim_generic|prokaryote_subset GO:0001686 biolink:CellularComponent obsolete axonemal dynein light chain OBSOLETE. (Was not defined before being made obsolete). go.json axonemal dynein light chain True http://purl.obolibrary.org/obo/GO_0001686 GO:0098632 biolink:MolecularActivity cell-cell adhesion mediator activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. go.json cell-cell adhesion molecule|protein binding involved in cell-cell adhesion http://purl.obolibrary.org/obo/GO_0098632 GO:0001687 biolink:CellularComponent obsolete cytoplasmic dynein heavy chain OBSOLETE. (Was not defined before being made obsolete). go.json cytoplasmic dynein heavy chain True http://purl.obolibrary.org/obo/GO_0001687 GO:0001688 biolink:CellularComponent obsolete cytoplasmic dynein intermediate chain OBSOLETE. (Was not defined before being made obsolete). go.json cytoplasmic dynein intermediate chain True http://purl.obolibrary.org/obo/GO_0001688 GO:0001689 biolink:CellularComponent obsolete cytoplasmic dynein intermediate light chain OBSOLETE. (Was not defined before being made obsolete). go.json cytoplasmic dynein intermediate light chain True http://purl.obolibrary.org/obo/GO_0001689 GO:0098630 biolink:BiologicalProcess aggregation of unicellular organisms The clustering together of unicellular organisms in suspension form aggregates. go.json aggregation of single cell organisms http://purl.obolibrary.org/obo/GO_0098630 GO:0001682 biolink:BiologicalProcess tRNA 5'-leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. go.json tRNA 5' leader removal http://purl.obolibrary.org/obo/GO_0001682 GO:0001683 biolink:CellularComponent obsolete axonemal dynein heavy chain OBSOLETE. (Was not defined before being made obsolete). go.json axonemal dynein heavy chain True http://purl.obolibrary.org/obo/GO_0001683 GO:0001684 biolink:CellularComponent obsolete axonemal dynein intermediate chain OBSOLETE. (Was not defined before being made obsolete). go.json axonemal dynein intermediate chain True http://purl.obolibrary.org/obo/GO_0001684 GO:0001685 biolink:CellularComponent obsolete axonemal dynein intermediate light chain OBSOLETE. (Was not defined before being made obsolete). go.json axonemal dynein intermediate light chain True http://purl.obolibrary.org/obo/GO_0001685 GO:0001680 biolink:BiologicalProcess tRNA 3'-terminal CCA addition Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. go.json http://purl.obolibrary.org/obo/GO_0001680 GO:1902489 biolink:BiologicalProcess hepatoblast apoptotic process Any apoptotic process in a hepatoblast. go.json hepatoblast apoptosis http://purl.obolibrary.org/obo/GO_1902489 GO:0001681 biolink:MolecularActivity sialate O-acetylesterase activity Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. EC:3.1.1.53|MetaCyc:RXN-13181|MetaCyc:RXN-13182 go.json N-acetylneuraminate acetyltransferase activity http://purl.obolibrary.org/obo/GO_0001681 GO:0060040 biolink:BiologicalProcess retinal bipolar neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina. go.json http://purl.obolibrary.org/obo/GO_0060040 GO:0060041 biolink:BiologicalProcess retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. go.json retina development in camera-style eye|retinal development http://purl.obolibrary.org/obo/GO_0060041 GO:1902487 biolink:BiologicalProcess protein localization to non-growing cell tip A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip. go.json protein localisation in non-growing cell tip|protein localisation to non-growing cell tip|protein localization in non-growing cell tip http://purl.obolibrary.org/obo/GO_1902487 GO:1902488 biolink:BiologicalProcess cholangiocyte apoptotic process Any apoptotic process in a cholangiocyte. go.json cholangiocyte apoptosis|epithelial cell of bile duct apoptosis|epithelial cell of bile duct apoptotic process http://purl.obolibrary.org/obo/GO_1902488 GO:0060042 biolink:BiologicalProcess retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized. go.json retina morphogenesis in camera-style eye|retinogenesis http://purl.obolibrary.org/obo/GO_0060042 GO:1902485 biolink:MolecularActivity L-cysteine binding Binding to L-cysteine. go.json http://purl.obolibrary.org/obo/GO_1902485 GO:0060043 biolink:BiologicalProcess regulation of cardiac muscle cell proliferation Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. go.json regulation of cardiomyocyte proliferation|regulation of heart muscle cell proliferation http://purl.obolibrary.org/obo/GO_0060043 GO:0060044 biolink:BiologicalProcess negative regulation of cardiac muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. go.json negative regulation of heart muscle cell proliferation http://purl.obolibrary.org/obo/GO_0060044 GO:1902486 biolink:BiologicalProcess protein localization to growing cell tip A process in which a protein is transported to, or maintained in, a location within a growing cell tip. go.json protein localisation in growing cell tip|protein localisation to growing cell tip|protein localization in growing cell tip http://purl.obolibrary.org/obo/GO_1902486 GO:1902494 biolink:CellularComponent catalytic complex A protein complex which is capable of catalytic activity. go.json enzyme complex http://purl.obolibrary.org/obo/GO_1902494 goslim_metagenomics GO:0060045 biolink:BiologicalProcess positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. go.json positive regulation of heart muscle cell proliferation http://purl.obolibrary.org/obo/GO_0060045 GO:1902495 biolink:CellularComponent transmembrane transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1902495 GO:0060046 biolink:BiologicalProcess regulation of acrosome reaction Any process that modulates the frequency, rate or extent of the acrosome reaction. go.json http://purl.obolibrary.org/obo/GO_0060046 GO:1902492 biolink:BiologicalProcess positive regulation of sperm capacitation Any process that activates or increases the frequency, rate or extent of sperm capacitation. go.json activation of sperm activation|activation of sperm capacitation|positive regulation of sperm activation|up regulation of sperm activation|up regulation of sperm capacitation|up-regulation of sperm activation|up-regulation of sperm capacitation|upregulation of sperm activation|upregulation of sperm capacitation http://purl.obolibrary.org/obo/GO_1902492 GO:0060047 biolink:BiologicalProcess heart contraction The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. go.json cardiac contraction|heart beating|hemolymph circulation http://purl.obolibrary.org/obo/GO_0060047 GO:1902493 biolink:CellularComponent acetyltransferase complex A protein complex which is capable of acetyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_1902493 GO:0011000 biolink:BiologicalProcess replication fork arrest at mating type locus A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus. go.json http://purl.obolibrary.org/obo/GO_0011000 GO:0060048 biolink:BiologicalProcess cardiac muscle contraction Muscle contraction of cardiac muscle tissue. go.json heart muscle contraction http://purl.obolibrary.org/obo/GO_0060048 GO:0060049 biolink:BiologicalProcess regulation of protein glycosylation Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. go.json regulation of protein amino acid glycosylation http://purl.obolibrary.org/obo/GO_0060049 GO:1902490 biolink:BiologicalProcess regulation of sperm capacitation Any process that modulates the frequency, rate or extent of sperm capacitation. go.json regulation of sperm activation http://purl.obolibrary.org/obo/GO_1902490 GO:1902491 biolink:BiologicalProcess negative regulation of sperm capacitation Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation. go.json down regulation of sperm activation|down regulation of sperm capacitation|down-regulation of sperm activation|down-regulation of sperm capacitation|downregulation of sperm activation|downregulation of sperm capacitation|inhibition of sperm activation|inhibition of sperm capacitation|negative regulation of sperm activation http://purl.obolibrary.org/obo/GO_1902491 GO:0098639 biolink:MolecularActivity collagen binding involved in cell-matrix adhesion Any collagen binding that occurs as part of cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_0098639 GO:0098637 biolink:CellularComponent protein complex involved in cell-matrix adhesion Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_0098637 GO:0098638 biolink:MolecularActivity laminin binding involved in cell-matrix adhesion Any laminin protein binding that occurs as part of cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_0098638 GO:0098635 biolink:CellularComponent protein complex involved in cell-cell adhesion Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0098635 GO:0098636 biolink:CellularComponent protein complex involved in cell adhesion Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. go.json cell adhesion complex http://purl.obolibrary.org/obo/GO_0098636 GO:0098633 biolink:MolecularActivity collagen fibril binding Binding to a collagen fibril. go.json http://purl.obolibrary.org/obo/GO_0098633 GO:0098634 biolink:MolecularActivity cell-matrix adhesion mediator activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix. go.json cell-matrix adhesion molecule|protein binding involved in cell-matrix adhesion http://purl.obolibrary.org/obo/GO_0098634 GO:0035092 biolink:BiologicalProcess sperm DNA condensation The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. go.json sperm chromatin condensation|spermatogenesis, exchange of chromosomal proteins http://purl.obolibrary.org/obo/GO_0035092 GO:0035093 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035093 GO:0035094 biolink:BiologicalProcess response to nicotine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. go.json http://purl.obolibrary.org/obo/GO_0035094 GO:0035095 biolink:BiologicalProcess behavioral response to nicotine Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. go.json behavioural response to nicotine http://purl.obolibrary.org/obo/GO_0035095 GO:0035096 biolink:BiologicalProcess larval midgut cell programmed cell death The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ. go.json larval midgut cell death|programmed cell death of larval midgut cells http://purl.obolibrary.org/obo/GO_0035096 GO:0035097 biolink:CellularComponent histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. go.json http://purl.obolibrary.org/obo/GO_0035097 goslim_pir GO:0035098 biolink:CellularComponent ESC/E(Z) complex A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. go.json Extra Sex Combs/Enhancer of Zeste complex|PRC2 complex http://purl.obolibrary.org/obo/GO_0035098 GO:0035099 biolink:BiologicalProcess hemocyte migration The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo. go.json arthropod blood cell migration|hemocyte cell migration http://purl.obolibrary.org/obo/GO_0035099 GO:0050602 biolink:MolecularActivity obsolete monoprenyl isoflavone epoxidase activity OBSOLETE. Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives. EC:1.14.99.34|MetaCyc:1.14.99.34-RXN go.json 7-O-methylluteone,NADPH:O2 oxidoreductase activity|7-O-methylluteone:O2 oxidoreductase activity|monoprenyl isoflavone monooxygenase activity True http://purl.obolibrary.org/obo/GO_0050602 GO:0050603 biolink:MolecularActivity thiophene-2-carbonyl-CoA monooxygenase activity Catalysis of the reaction: AH(2) + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H+. EC:1.14.99.35|KEGG_REACTION:R05742|MetaCyc:1.14.99.35-RXN|RHEA:18929|UM-BBD_reactionID:r1235 go.json thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity|thiophene-2-carboxyl-CoA dehydrogenase activity|thiophene-2-carboxyl-CoA hydroxylase activity|thiophene-2-carboxyl-CoA monooxygenase activity http://purl.obolibrary.org/obo/GO_0050603 GO:0050600 biolink:MolecularActivity acyl-CoA 11-(E)-desaturase activity Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. EC:1.14.19.24|MetaCyc:1.14.99.31-RXN|RHEA:46396 go.json acyl-CoA delta11-desaturase activity|myristoyl-CoA 11-(E) desaturase activity http://purl.obolibrary.org/obo/GO_0050600 GO:0035090 biolink:BiologicalProcess maintenance of apical/basal cell polarity Retaining the established polarization of a cell along its apical/basal axis. go.json http://purl.obolibrary.org/obo/GO_0035090 GO:0035091 biolink:MolecularActivity phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. go.json phosphoinositide binding http://purl.obolibrary.org/obo/GO_0035091 GO:0050601 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050601 GO:0050606 biolink:MolecularActivity 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + H+ + NADPH. EC:1.1.1.312|KEGG_REACTION:R04279|MetaCyc:1.2.1.45-RXN|RHEA:29587 go.json 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity|4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity|4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity|alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050606 GO:0050607 biolink:MolecularActivity mycothiol-dependent formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+. EC:1.1.1.306|MetaCyc:1.2.1.66-RXN|RHEA:28502 go.json NAD/factor-dependent formaldehyde dehydrogenase activity|formaldehyde:NAD+ oxidoreductase (mycothiol-formylating) http://purl.obolibrary.org/obo/GO_0050607 GO:0050604 biolink:MolecularActivity taxadiene 5-alpha-hydroxylase activity Catalysis of the reaction: AH(2) + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol. EC:1.14.14.176|KEGG_REACTION:R06306|MetaCyc:1.14.99.37-RXN|RHEA:14049 go.json taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)|taxadiene 5a-hydroxylase activity|taxadiene 5alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050604 GO:0050605 biolink:MolecularActivity superoxide reductase activity Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin. EC:1.15.1.2|MetaCyc:1.15.1.2-RXN|RHEA:21324 go.json desulfoferrodoxin activity|neelaredoxin activity|rubredoxin:superoxide oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050605 GO:0050608 biolink:MolecularActivity vanillin dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + vanillin = 2 H+ + NADH + vanillate. EC:1.2.1.67|KEGG_REACTION:R05699|MetaCyc:1.2.1.67-RXN|RHEA:13309 go.json vanillin:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050608 GO:0050609 biolink:MolecularActivity phosphonate dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate. EC:1.20.1.1|KEGG_REACTION:R05746|MetaCyc:1.20.1.1-RXN|RHEA:13173|UM-BBD_reactionID:r1055 go.json NAD-dependent phosphite dehydrogenas activity|NAD:phosphite oxidoreductase activity|phosphite dehydrogenase activity|phosphonate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050609 GO:0035089 biolink:BiologicalProcess establishment of apical/basal cell polarity The specification and formation of the polarity of a cell along its apical/basal axis. go.json http://purl.obolibrary.org/obo/GO_0035089 GO:0035081 biolink:BiologicalProcess induction of programmed cell death by hormones Any process induced by hormones that directly activates any of the steps required for programmed cell death. go.json http://purl.obolibrary.org/obo/GO_0035081 GO:0035082 biolink:BiologicalProcess axoneme assembly The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. go.json axoneme biogenesis|ciliary axoneme assembly|cilium axoneme assembly|cilium axoneme biogenesis|flagellar axoneme assembly|flagellum axoneme assembly http://purl.obolibrary.org/obo/GO_0035082 GO:0035083 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035083 GO:0035084 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035084 GO:0035085 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035085 GO:0035086 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035086 GO:0035087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035087 GO:0035088 biolink:BiologicalProcess establishment or maintenance of apical/basal cell polarity Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. go.json http://purl.obolibrary.org/obo/GO_0035088 GO:0050610 biolink:MolecularActivity methylarsonate reductase activity Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid. EC:1.20.4.2|KEGG_REACTION:R05748|MetaCyc:1.20.4.2-RXN|RHEA:15969|Reactome:R-HSA-5696230|UM-BBD_reactionID:r0837 go.json MMA(V) reductase activity|glutathione:methylarsonate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050610 GO:0050613 biolink:MolecularActivity delta14-sterol reductase activity Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. EC:1.3.1.70|MetaCyc:RXN66-14|RHEA:18561|Reactome:R-HSA-194674|Reactome:R-HSA-194698 go.json 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity|C-14 sterol reductase activity|D14-sterol reductase activity|sterol C-14 reductase activity|sterol C14-reductase activity http://purl.obolibrary.org/obo/GO_0050613 GO:0050614 biolink:MolecularActivity delta24-sterol reductase activity Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. EC:1.3.1.72|MetaCyc:RXN66-321|RHEA:13685|Reactome:R-HSA-196417|Reactome:R-HSA-6807064|Reactome:R-HSA-9755937 go.json D24-sterol reductase activity|lanosterol Delta(24)-reductase activity|lanosterol delta24-reductase activity|sterol:NADP+ delta24-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050614 GO:0050611 biolink:MolecularActivity arsenate reductase (azurin) activity Catalysis of the reaction: H2O + arsenite + 2 oxidized azurin = 2 H+ + 2 reduced azurin + arsenate. EC:1.20.9.1|MetaCyc:1.20.98.1-RXN|RHEA:18701|UM-BBD_reactionID:r0634 go.json arsenite oxidase activity|arsenite:azurin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050611 GO:0050612 biolink:MolecularActivity arsenate reductase (donor) activity Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+. EC:1.20.99.1|KEGG_REACTION:R05752|MetaCyc:1.20.99.1-RXN|RHEA:18449 go.json arsenate:(acceptor) oxidoreductase activity|arsenate:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050612 GO:0035080 biolink:BiologicalProcess heat shock-mediated polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus. go.json http://purl.obolibrary.org/obo/GO_0035080 GO:0050617 biolink:MolecularActivity 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. EC:1.3.7.2|MetaCyc:1.3.7.2-RXN|RHEA:10168 go.json PebA http://purl.obolibrary.org/obo/GO_0050617 GO:0050618 biolink:MolecularActivity phycoerythrobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin. EC:1.3.7.3|MetaCyc:1.3.7.3-RXN|RHEA:22092 go.json (3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity|PebB http://purl.obolibrary.org/obo/GO_0050618 GO:0050615 biolink:MolecularActivity 1,2-dihydrovomilenine reductase activity Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH. EC:1.3.1.73|KEGG_REACTION:R05879|MetaCyc:1.3.1.73-RXN|RHEA:12320 go.json 17-O-acetylnorajmaline:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050615 GO:0050616 biolink:MolecularActivity secologanin synthase activity Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O. EC:1.14.19.62|MetaCyc:1.3.3.9-RXN|RHEA:20585 go.json loganin:oxygen oxidoreductase (ring-cleaving) http://purl.obolibrary.org/obo/GO_0050616 GO:0050619 biolink:MolecularActivity phytochromobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. EC:1.3.7.4|MetaCyc:1.3.7.4-RXN|RHEA:16377 go.json (3Z)-phytochromobilin:ferredoxin oxidoreductase activity|HY2|P-Phi-B synthase activity|PFB synthase activity|PPhiB synthase activity|phytochromobilin synthase activity http://purl.obolibrary.org/obo/GO_0050619 GO:0035078 biolink:BiologicalProcess induction of programmed cell death by ecdysone Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death. go.json http://purl.obolibrary.org/obo/GO_0035078 GO:0035079 biolink:BiologicalProcess polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals. go.json http://purl.obolibrary.org/obo/GO_0035079 GO:0035070 biolink:BiologicalProcess salivary gland histolysis The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. go.json salivary gland regression http://purl.obolibrary.org/obo/GO_0035070 GO:0035071 biolink:BiologicalProcess salivary gland cell autophagic cell death The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis. go.json autophagic cell death of salivary gland cells|programmed cell death of salivary gland cells by autophagy|salivary gland cell death|salivary gland cell programmed cell death by autophagy http://purl.obolibrary.org/obo/GO_0035071 GO:0035072 biolink:BiologicalProcess ecdysone-mediated induction of salivary gland cell autophagic cell death Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis. go.json ecdysone-mediated induction of autophagic cell death of salivary gland cells|ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy|ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy http://purl.obolibrary.org/obo/GO_0035072 GO:0035073 biolink:BiologicalProcess pupariation The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis. go.json puparium biosynthesis|puparium formation http://purl.obolibrary.org/obo/GO_0035073 GO:0035074 biolink:BiologicalProcess pupation The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period. Wikipedia:Pupa go.json head eversion|prepupal-pupal transition http://purl.obolibrary.org/obo/GO_0035074 GO:0035075 biolink:BiologicalProcess response to ecdysone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. go.json http://purl.obolibrary.org/obo/GO_0035075 GO:0035076 biolink:BiologicalProcess ecdysone receptor-mediated signaling pathway The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex. go.json ecdysone receptor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0035076 GO:0035077 biolink:BiologicalProcess ecdysone-mediated polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation. go.json http://purl.obolibrary.org/obo/GO_0035077 GO:0050620 biolink:MolecularActivity phycocyanobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. EC:1.3.7.5|MetaCyc:1.3.7.5-RXN|RHEA:15309 go.json (3Z)-phycocyanobilin:ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050620 GO:0050621 biolink:MolecularActivity tryptophan alpha,beta-oxidase activity Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+. EC:1.3.3.10|KEGG_REACTION:R05317|MetaCyc:1.4.3.17-RXN|RHEA:19901 go.json L-tryptophan 2',3'-oxidase activity|L-tryptophan alpha,beta-dehydrogenase activity|L-tryptophan:oxygen alpha,beta-oxidoreductase activity|tryptophan a,b-oxidase activity http://purl.obolibrary.org/obo/GO_0050621 GO:0050624 biolink:MolecularActivity vomilenine reductase activity Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = H+ + NADPH + vomilenine. EC:1.5.1.32|KEGG_REACTION:R05878|MetaCyc:1.5.1.32-RXN|RHEA:16409 go.json 1,2-dihydrovomilenine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050624 GO:0050625 biolink:MolecularActivity 2-hydroxy-1,4-benzoquinone reductase activity Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H+ + NADH = benzene-1,2,4-triol + NAD+. EC:1.6.5.7|KEGG_REACTION:R05399|MetaCyc:1.6.5.7-RXN|RHEA:12428|UM-BBD_reactionID:r0667 go.json 1,2,4-trihydroxybenzene:NAD oxidoreductase activity|1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity|2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity|NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity|hydroxybenzoquinone reductase activity http://purl.obolibrary.org/obo/GO_0050625 GO:0050622 biolink:MolecularActivity glycine dehydrogenase (cyanide-forming) activity Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. EC:1.4.99.5|MetaCyc:1.4.99.5-RXN|RHEA:15821 go.json HCN synthase activity|glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)|hydrogen cyanide synthase activity http://purl.obolibrary.org/obo/GO_0050622 GO:0050623 biolink:MolecularActivity berberine reductase activity Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH. EC:1.5.1.31|KEGG_REACTION:R07169|MetaCyc:1.5.1.31-RXN|RHEA:21268 go.json (R)-canadine synthase activity|(R)-tetrahydroberberine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050623 GO:0050628 biolink:MolecularActivity 2-oxopropyl-CoM reductase (carboxylating) activity Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH. EC:1.8.1.5|KEGG_REACTION:R05713|MetaCyc:1.8.1.5-RXN|RHEA:16977|UM-BBD_reactionID:r0854 go.json 2-KPCC activity|2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)|NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity|NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity http://purl.obolibrary.org/obo/GO_0050628 GO:0050629 biolink:MolecularActivity tetrachloroethene reductive dehalogenase activity Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. EC:1.21.99.5|MetaCyc:1.97.1.8-RXN|RHEA:20353 go.json acceptor:trichloroethene oxidoreductase (chlorinating)|tetrachloroethene reductase activity http://purl.obolibrary.org/obo/GO_0050629 GO:0050626 biolink:MolecularActivity trimethylamine-N-oxide reductase (cytochrome c) activity Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+. EC:1.7.2.3|MetaCyc:1.7.2.3-RXN|RHEA:24236|Wikipedia:Trimethylamine_N-oxide_reductase go.json TMAO reductase activity|TOR activity|trimethylamine:cytochrome c oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050626 GO:0050627 biolink:MolecularActivity mycothione reductase activity Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione. EC:1.8.1.15|MetaCyc:1.8.1.15-RXN go.json mycothiol-disulfide reductase activity|mycothiol:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050627 GO:0035067 biolink:BiologicalProcess negative regulation of histone acetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. go.json down regulation of histone acetylation|down-regulation of histone acetylation|downregulation of histone acetylation|inhibition of histone acetylation http://purl.obolibrary.org/obo/GO_0035067 GO:0035068 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035068 GO:0035069 biolink:BiologicalProcess larval midgut histolysis The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. go.json larval midgut regression http://purl.obolibrary.org/obo/GO_0035069 GO:0035060 biolink:CellularComponent brahma complex A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. go.json BRM complex http://purl.obolibrary.org/obo/GO_0035060 GO:0035061 biolink:CellularComponent interchromatin granule A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs). NIF_Subcellular:sao1049471211 go.json ICG http://purl.obolibrary.org/obo/GO_0035061 GO:0035062 biolink:CellularComponent omega speckle A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs). go.json http://purl.obolibrary.org/obo/GO_0035062 GO:0035063 biolink:BiologicalProcess nuclear speck organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized. go.json nuclear speck organisation|nuclear speck organization and biogenesis|nuclear speckle assembly|nuclear speckle organization http://purl.obolibrary.org/obo/GO_0035063 GO:0035064 biolink:MolecularActivity methylated histone binding Binding to a histone in which a residue has been modified by methylation. go.json http://purl.obolibrary.org/obo/GO_0035064 GO:0035065 biolink:BiologicalProcess regulation of histone acetylation Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein. go.json http://purl.obolibrary.org/obo/GO_0035065 GO:0035066 biolink:BiologicalProcess positive regulation of histone acetylation Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. go.json activation of histone acetylation|stimulation of histone acetylation|up regulation of histone acetylation|up-regulation of histone acetylation|upregulation of histone acetylation http://purl.obolibrary.org/obo/GO_0035066 GO:0050631 biolink:MolecularActivity corydaline synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+. EC:2.1.1.147|KEGG_REACTION:R07241|MetaCyc:2.1.1.147-RXN|RHEA:14773 go.json S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity http://purl.obolibrary.org/obo/GO_0050631 GO:0050632 biolink:MolecularActivity propionyl-CoA C2-trimethyltridecanoyltransferase activity Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA. EC:2.3.1.176|KEGG_REACTION:R05330|MetaCyc:2.3.1.154-RXN|RHEA:10408|Reactome:R-HSA-192341|Reactome:R-HSA-193533|Reactome:R-HSA-2066781|Reactome:R-HSA-390224 go.json 3-oxopristanoyl-CoA hydrolase activity|3-oxopristanoyl-CoA thiolase activity|4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity|4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity|SCPx|oxopristanoyl-CoA thiolase activity|peroxisomal 3-oxoacyl coenzyme A thiolase|peroxisome sterol carrier protein thiolase|propionyl-CoA C(2)-trimethyltridecanoyltransferase activity|sterol carrier protein|sterol carrier protein X-related thiolase activity http://purl.obolibrary.org/obo/GO_0050632 GO:0050630 biolink:MolecularActivity (iso)eugenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol. EC:2.1.1.146|MetaCyc:2.1.1.146-RXN|RHEA:17081 go.json S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity|isoeugenol O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0050630 GO:0050635 biolink:MolecularActivity acridone synthase activity Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H+ + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O. EC:2.3.1.159|KEGG_REACTION:R07250|MetaCyc:2.3.1.159-RXN|RHEA:22224 go.json malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing) http://purl.obolibrary.org/obo/GO_0050635 GO:0050636 biolink:MolecularActivity vinorine synthase activity Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine. EC:2.3.1.160|KEGG_REACTION:R05876|MetaCyc:2.3.1.160-RXN|RHEA:24016 go.json acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing) http://purl.obolibrary.org/obo/GO_0050636 GO:0050633 biolink:MolecularActivity acetyl-CoA C-myristoyltransferase activity Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA. EC:2.3.1.155|MetaCyc:2.3.1.155-RXN|RHEA:18161 go.json 3-oxopalmitoyl-CoA hydrolase activity|3-oxopalmitoyl-CoA-CoA acetyltransferase activity|myristoyl-CoA C-acetyltransferase activity|myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity http://purl.obolibrary.org/obo/GO_0050633 GO:0050634 biolink:MolecularActivity phloroisovalerophenone synthase activity Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one. EC:2.3.1.156|MetaCyc:2.3.1.156-RXN|RHEA:23572 go.json 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity|isovaleryl-CoA:malonyl-CoA acyltransferase activity|valerophenone synthase activity http://purl.obolibrary.org/obo/GO_0050634 GO:0050639 biolink:MolecularActivity 10-hydroxytaxane O-acetyltransferase activity Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C. EC:2.3.1.163|KEGG_REACTION:R07252|MetaCyc:2.3.1.163-RXN|RHEA:18837 go.json acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity|acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity|acetyl-CoA:taxan-10beta-ol O-acetyltransferase http://purl.obolibrary.org/obo/GO_0050639 GO:0050637 biolink:MolecularActivity lovastatin nonaketide synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+. EC:2.3.1.161|KEGG_REACTION:R07251|MetaCyc:2.3.1.161-RXN|RHEA:18565 go.json acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) http://purl.obolibrary.org/obo/GO_0050637 GO:0050638 biolink:MolecularActivity taxadien-5-alpha-ol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate. EC:2.3.1.162|KEGG_REACTION:R06307|MetaCyc:2.3.1.162-RXN|RHEA:22028 go.json acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity|acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity|acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity|taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity|taxadien-5a-ol O-acetyltransferase activity|taxadien-5alpha-ol O-acetyltransferase activity|taxadienol acetyltransferase activity http://purl.obolibrary.org/obo/GO_0050638 GO:0035056 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035056 GO:0035057 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035057 GO:0035058 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035058 GO:0035059 biolink:CellularComponent RCAF complex A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4. go.json replication-coupling assembly factor complex http://purl.obolibrary.org/obo/GO_0035059 GO:0035050 biolink:BiologicalProcess embryonic heart tube development The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. go.json http://purl.obolibrary.org/obo/GO_0035050 GO:0035051 biolink:BiologicalProcess cardiocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. go.json cardiac cell differentiation|heart cell differentiation http://purl.obolibrary.org/obo/GO_0035051 GO:0035052 biolink:BiologicalProcess dorsal vessel aortic cell fate commitment The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0035052 GO:0035053 biolink:BiologicalProcess dorsal vessel heart proper cell fate commitment The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0035053 GO:0035054 biolink:BiologicalProcess embryonic heart tube anterior/posterior pattern specification The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta. go.json http://purl.obolibrary.org/obo/GO_0035054 GO:0035055 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035055 GO:0050642 biolink:MolecularActivity 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA. EC:2.3.1.166|KEGG_REACTION:R06310|MetaCyc:2.3.1.166-RXN|RHEA:18741 go.json 2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity|2a-hydroxytaxane 2-O-benzoyltransferase activity|2alpha-hydroxytaxane 2-O-benzoyltransferase activity|benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity|benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity|benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity http://purl.obolibrary.org/obo/GO_0050642 GO:0050643 biolink:MolecularActivity 10-deacetylbaccatin III 10-O-acetyltransferase activity Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA. EC:2.3.1.167|KEGG_REACTION:R06311|MetaCyc:2.3.1.167-RXN|RHEA:20137 go.json acetyl-CoA:taxan-10beta-ol O-acetyltransferase http://purl.obolibrary.org/obo/GO_0050643 GO:0050640 biolink:MolecularActivity isopenicillin-N N-acyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate. EC:2.3.1.164|MetaCyc:2.3.1.164-RXN|RHEA:20720 go.json acyl-CoA:isopenicillin N N-acyltransferase activity|acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity|acyl-coenzyme A:isopenicillin N acyltransferase activity|isopenicillin N:acyl-CoA acyltransferase activity|isopenicillin-N acyltransferase activity http://purl.obolibrary.org/obo/GO_0050640 GO:0050641 biolink:MolecularActivity 6-methylsalicylic acid synthase activity Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+. EC:2.3.1.165|KEGG_REACTION:R07253|MetaCyc:2.3.1.165-RXN|RHEA:12240 go.json 6-MSAS activity|MSAS activity|acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing) http://purl.obolibrary.org/obo/GO_0050641 GO:0050646 biolink:MolecularActivity 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. go.json 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding http://purl.obolibrary.org/obo/GO_0050646 GO:0050647 biolink:MolecularActivity 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. go.json 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding http://purl.obolibrary.org/obo/GO_0050647 GO:0050644 biolink:MolecularActivity cis-p-coumarate glucosyltransferase activity Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP. EC:2.4.1.209|KEGG_REACTION:R05324|MetaCyc:2.4.1.209-RXN|RHEA:13129 go.json UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050644 GO:0050645 biolink:MolecularActivity limonoid glucosyltransferase activity Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP. EC:2.4.1.210|MetaCyc:2.4.1.210-RXN|RHEA:11256 go.json LGTase activity|limonoid UDP-glucosyltransferase activity|uridine diphosphoglucose-limonoid glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050645 GO:0050648 biolink:MolecularActivity 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. go.json 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding http://purl.obolibrary.org/obo/GO_0050648 GO:0050649 biolink:MolecularActivity testosterone 6-beta-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. go.json testosterone 6b-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050649 GO:0035045 biolink:BiologicalProcess sperm plasma membrane disassembly The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg. go.json sperm plasma membrane breakdown|sperm plasma membrane catabolism|sperm plasma membrane degradation http://purl.obolibrary.org/obo/GO_0035045 GO:0035046 biolink:BiologicalProcess pronuclear migration The directed movement of the male and female pronuclei towards each other prior to their fusion. go.json http://purl.obolibrary.org/obo/GO_0035046 GO:0035047 biolink:BiologicalProcess centrosomal and pronuclear rotation The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion. go.json http://purl.obolibrary.org/obo/GO_0035047 GO:0035048 biolink:BiologicalProcess obsolete splicing factor protein import into nucleus OBSOLETE. The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane. go.json splicing factor protein transport from cytoplasm to nucleus|splicing factor protein-nucleus import True http://purl.obolibrary.org/obo/GO_0035048 GO:0035049 biolink:MolecularActivity juvenile hormone acid methyltransferase activity Catalysis of the transfer of a methyl group to juvenile hormone acid. go.json http://purl.obolibrary.org/obo/GO_0035049 GO:0035040 biolink:BiologicalProcess sperm nuclear envelope removal Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus. go.json http://purl.obolibrary.org/obo/GO_0035040 GO:0035041 biolink:BiologicalProcess sperm DNA decondensation Unwinding of the condensed nuclear chromatin of an inactive male pronucleus after fertilization. go.json sperm chromatin decondensation http://purl.obolibrary.org/obo/GO_0035041 GO:0035042 biolink:BiologicalProcess obsolete fertilization, exchange of chromosomal proteins OBSOLETE. Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity. go.json sperm-specific histone exchange|sperm-specific histone replacement True http://purl.obolibrary.org/obo/GO_0035042 GO:0035043 biolink:BiologicalProcess male pronuclear envelope synthesis Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation. go.json http://purl.obolibrary.org/obo/GO_0035043 GO:0035044 biolink:BiologicalProcess sperm aster formation Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei. go.json http://purl.obolibrary.org/obo/GO_0035044 GO:0050653 biolink:BiologicalProcess chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate. go.json chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism|chondroitin sulfate proteoglycan chain elongation|chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis|chondroitin sulfate proteoglycan formation, polysaccharide chain formation|chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis|chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis|chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process http://purl.obolibrary.org/obo/GO_0050653 GO:0050654 biolink:BiologicalProcess chondroitin sulfate proteoglycan metabolic process The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. go.json chondroitin sulfate proteoglycan metabolism|chondroitin sulphate proteoglycan metabolic process|chondroitin sulphate proteoglycan metabolism http://purl.obolibrary.org/obo/GO_0050654 GO:0050651 biolink:BiologicalProcess dermatan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. go.json chondroitin sulfate B proteoglycan biosynthesis|chondroitin sulfate B proteoglycan biosynthetic process|dermatan sulfate proteoglycan anabolism|dermatan sulfate proteoglycan biosynthesis|dermatan sulfate proteoglycan formation|dermatan sulfate proteoglycan synthesis|dermatan sulphate proteoglycan biosynthesis|dermatan sulphate proteoglycan biosynthetic process http://purl.obolibrary.org/obo/GO_0050651 GO:1902409 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902409 GO:0050652 biolink:BiologicalProcess dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate. go.json chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis|chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process|chondroitin sulfate B proteoglycan chain elongation|dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism|dermatan sulfate proteoglycan chain elongation|dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis|dermatan sulfate proteoglycan formation, polysaccharide chain formation|dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis|dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis|dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process http://purl.obolibrary.org/obo/GO_0050652 GO:0050657 biolink:BiologicalProcess nucleic acid transport The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0050657 GO:1902407 biolink:BiologicalProcess assembly of actomyosin apparatus involved in mitotic cytokinesis Any assembly of mitotic cytokinetic actomyosin apparatus. go.json actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle|cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle|formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1902407 GO:1902408 biolink:BiologicalProcess mitotic cytokinesis, division site positioning The process in which a contractile ring is positioned in a specific location during the mitotic cell cycle. This process is critical for both for both symmetric and asymmetric cell divisions. go.json mitotic cytokinesis, site selection http://purl.obolibrary.org/obo/GO_1902408 GO:0050658 biolink:BiologicalProcess RNA transport The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0050658 GO:0050655 biolink:BiologicalProcess dermatan sulfate proteoglycan metabolic process The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. go.json chondroitin sulfate B proteoglycan metabolic process|chondroitin sulfate B proteoglycan metabolism|dermatan sulfate proteoglycan metabolism|dermatan sulphate proteoglycan metabolic process|dermatan sulphate proteoglycan metabolism http://purl.obolibrary.org/obo/GO_0050655 GO:1902405 biolink:BiologicalProcess obsolete mitotic actomyosin contractile ring localization OBSOLETE. Any actomyosin contractile ring localization that is involved in mitotic cell cycle. go.json True http://purl.obolibrary.org/obo/GO_1902405 GO:0050656 biolink:MolecularActivity 3'-phosphoadenosine 5'-phosphosulfate binding Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. go.json 3'-phosphoadenosine 5'-phosphosulphate binding|3'-phosphoadenylyl-sulfate binding|PAPS binding|adenosine 3'-phosphate 5'-phosphosulfate binding|phosphoadenosine phosphosulfate binding http://purl.obolibrary.org/obo/GO_0050656 GO:1902406 biolink:BiologicalProcess mitotic actomyosin contractile ring maturation The cellular process in which the mitotic contractile ring cytokinetic ring attains its fully functional state. go.json http://purl.obolibrary.org/obo/GO_1902406 GO:1902403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902403 GO:1902404 biolink:BiologicalProcess mitotic actomyosin contractile ring contraction Any actomyosin contractile ring contraction that is involved in mitotic cell cycle. go.json contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|mitotic actomyosin contractile ring constriction http://purl.obolibrary.org/obo/GO_1902404 GO:0050659 biolink:MolecularActivity N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. EC:2.8.2.33|KEGG_REACTION:R02181|KEGG_REACTION:R07288|MetaCyc:RXN-7953|MetaCyc:RXN-7954|Reactome:R-HSA-2018659 go.json 3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity|GalNAc4S-6ST|N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0050659 GO:1902401 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic DNA damage checkpoint OBSOLETE. Any detection of stimulus that is involved in mitotic DNA damage checkpoint. go.json perception of stimulus involved in mitotic DNA damage checkpoint|stimulus detection involved in mitotic DNA damage checkpoint|stimulus sensing involved in mitotic DNA damage checkpoint True http://purl.obolibrary.org/obo/GO_1902401 GO:1902402 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902402 GO:1902400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902400 GO:0035034 biolink:MolecularActivity histone acetyltransferase regulator activity Binds to and modulates the activity of histone acetyltransferase. go.json histone acetylase regulator activity http://purl.obolibrary.org/obo/GO_0035034 GO:0035035 biolink:MolecularActivity histone acetyltransferase binding Binding to an histone acetyltransferase. go.json histone acetylase binding http://purl.obolibrary.org/obo/GO_0035035 GO:0035036 biolink:BiologicalProcess sperm-egg recognition The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. go.json http://purl.obolibrary.org/obo/GO_0035036 GO:0035037 biolink:BiologicalProcess sperm entry An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur. go.json http://purl.obolibrary.org/obo/GO_0035037 GO:0035038 biolink:BiologicalProcess female pronucleus assembly Assembly of the haploid nucleus of the unfertilized egg. go.json http://purl.obolibrary.org/obo/GO_0035038 GO:0035039 biolink:BiologicalProcess male pronucleus assembly The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division. go.json male pronucleus formation http://purl.obolibrary.org/obo/GO_0035039 GO:0035030 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035030 GO:0050650 biolink:BiologicalProcess chondroitin sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. go.json chondroitin sulfate proteoglycan anabolism|chondroitin sulfate proteoglycan biosynthesis|chondroitin sulfate proteoglycan formation|chondroitin sulfate proteoglycan synthesis|chondroitin sulphate proteoglycan biosynthesis|chondroitin sulphate proteoglycan biosynthetic process http://purl.obolibrary.org/obo/GO_0050650 GO:0035031 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035031 GO:0035032 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class III A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). go.json class III PI3K complex|phosphoinositide 3-kinase complex, class III http://purl.obolibrary.org/obo/GO_0035032 GO:0035033 biolink:MolecularActivity histone deacetylase regulator activity Binds to and modulates the activity of histone deacetylase. go.json http://purl.obolibrary.org/obo/GO_0035033 GO:0001810 biolink:BiologicalProcess regulation of type I hypersensitivity Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0001810 GO:0001819 biolink:BiologicalProcess positive regulation of cytokine production Any process that activates or increases the frequency, rate or extent of production of a cytokine. go.json activation of cytokine production|positive regulation of cytokine biosynthetic process|positive regulation of cytokine secretion|stimulation of cytokine production|up regulation of cytokine production|up-regulation of cytokine production|upregulation of cytokine production http://purl.obolibrary.org/obo/GO_0001819 GO:0001815 biolink:BiologicalProcess positive regulation of antibody-dependent cellular cytotoxicity Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity. go.json activation of antibody-dependent cellular cytotoxicity|positive regulation of antibody dependent cell death|positive regulation of antibody dependent cell killing|positive regulation of antibody-dependent cell death|positive regulation of antibody-dependent cell killing|stimulation of antibody-dependent cellular cytotoxicity|up regulation of antibody-dependent cellular cytotoxicity|up-regulation of antibody-dependent cellular cytotoxicity|upregulation of antibody-dependent cellular cytotoxicity http://purl.obolibrary.org/obo/GO_0001815 GO:0001816 biolink:BiologicalProcess cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json cytokine biosynthetic process|cytokine metabolic process|cytokine secretion|interferon production|interferon secretion|interleukin production|interleukin secretion http://purl.obolibrary.org/obo/GO_0001816 gocheck_do_not_annotate|goslim_pir GO:0001817 biolink:BiologicalProcess regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine. go.json regulation of cytokine anabolism|regulation of cytokine biosynthesis|regulation of cytokine biosynthetic process|regulation of cytokine formation|regulation of cytokine secretion|regulation of cytokine synthesis http://purl.obolibrary.org/obo/GO_0001817 GO:0001818 biolink:BiologicalProcess negative regulation of cytokine production Any process that stops, prevents, or reduces the rate of production of a cytokine. go.json down regulation of cytokine biosynthetic process|down regulation of cytokine production|down-regulation of cytokine biosynthetic process|down-regulation of cytokine production|downregulation of cytokine biosynthetic process|downregulation of cytokine production|inhibition of cytokine biosynthetic process|inhibition of cytokine production|negative regulation of cytokine anabolism|negative regulation of cytokine biosynthesis|negative regulation of cytokine biosynthetic process|negative regulation of cytokine formation|negative regulation of cytokine secretion|negative regulation of cytokine synthesis http://purl.obolibrary.org/obo/GO_0001818 GO:0001811 biolink:BiologicalProcess negative regulation of type I hypersensitivity Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response. go.json down regulation of type I hypersensitivity|down-regulation of type I hypersensitivity|downregulation of type I hypersensitivity|inhibition of type I hypersensitivity http://purl.obolibrary.org/obo/GO_0001811 GO:0001812 biolink:BiologicalProcess positive regulation of type I hypersensitivity Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response. go.json activation of type I hypersensitivity|stimulation of type I hypersensitivity|up regulation of type I hypersensitivity|up-regulation of type I hypersensitivity|upregulation of type I hypersensitivity http://purl.obolibrary.org/obo/GO_0001812 GO:0001813 biolink:BiologicalProcess regulation of antibody-dependent cellular cytotoxicity Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity. go.json regulation of antibody dependent cell death|regulation of antibody dependent cell killing|regulation of antibody-dependent cell death|regulation of antibody-dependent cell killing http://purl.obolibrary.org/obo/GO_0001813 GO:0001814 biolink:BiologicalProcess negative regulation of antibody-dependent cellular cytotoxicity Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity. go.json down regulation of antibody-dependent cellular cytotoxicity|down-regulation of antibody-dependent cellular cytotoxicity|downregulation of antibody-dependent cellular cytotoxicity|inhibition of antibody-dependent cellular cytotoxicity|negative regulation of antibody dependent cell death|negative regulation of antibody dependent cell killing|negative regulation of antibody-dependent cell death|negative regulation of antibody-dependent cell killing http://purl.obolibrary.org/obo/GO_0001814 GO:0001820 biolink:BiologicalProcess serotonin secretion The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. go.json 5-HT secretion|5-hydroxytryptamine secretion|serotonin release http://purl.obolibrary.org/obo/GO_0001820 GO:0001821 biolink:BiologicalProcess histamine secretion The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems. go.json http://purl.obolibrary.org/obo/GO_0001821 GO:0001826 biolink:BiologicalProcess inner cell mass cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. go.json http://purl.obolibrary.org/obo/GO_0001826 GO:0001827 biolink:BiologicalProcess inner cell mass cell fate commitment The cell fate commitment of precursor cells that will become inner cell mass cells. go.json http://purl.obolibrary.org/obo/GO_0001827 GO:0001828 biolink:BiologicalProcess inner cell mass cellular morphogenesis The morphogenesis of cells in the inner cell mass. go.json http://purl.obolibrary.org/obo/GO_0001828 GO:0001829 biolink:BiologicalProcess trophectodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. go.json trophectoderm cell differentiation http://purl.obolibrary.org/obo/GO_0001829 GO:0001822 biolink:BiologicalProcess kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. Wikipedia:Kidney_development go.json nephrogenesis http://purl.obolibrary.org/obo/GO_0001822 GO:0001823 biolink:BiologicalProcess mesonephros development The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. go.json Wolffian body development http://purl.obolibrary.org/obo/GO_0001823 GO:0001824 biolink:BiologicalProcess blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. go.json http://purl.obolibrary.org/obo/GO_0001824 GO:0001825 biolink:BiologicalProcess blastocyst formation The initial formation of a blastocyst from a solid ball of cells known as a morula. go.json http://purl.obolibrary.org/obo/GO_0001825 GO:0001808 biolink:BiologicalProcess negative regulation of type IV hypersensitivity Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response. go.json down regulation of type IV hypersensitivity|down-regulation of type IV hypersensitivity|downregulation of type IV hypersensitivity|inhibition of type IV hypersensitivity http://purl.obolibrary.org/obo/GO_0001808 GO:0001809 biolink:BiologicalProcess positive regulation of type IV hypersensitivity Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response. go.json activation of type IV hypersensitivity|stimulation of type IV hypersensitivity|up regulation of type IV hypersensitivity|up-regulation of type IV hypersensitivity|upregulation of type IV hypersensitivity http://purl.obolibrary.org/obo/GO_0001809 GO:0001804 biolink:BiologicalProcess negative regulation of type III hypersensitivity Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response. go.json down regulation of type III hypersensitivity|down-regulation of type III hypersensitivity|downregulation of type III hypersensitivity|inhibition of type III hypersensitivity http://purl.obolibrary.org/obo/GO_0001804 GO:0001805 biolink:BiologicalProcess positive regulation of type III hypersensitivity Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response. go.json activation of type III hypersensitivity|stimulation of type III hypersensitivity|up regulation of type III hypersensitivity|up-regulation of type III hypersensitivity|upregulation of type III hypersensitivity http://purl.obolibrary.org/obo/GO_0001805 GO:0001806 biolink:BiologicalProcess type IV hypersensitivity An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation. Wikipedia:Type_IV_hypersensitivity go.json delayed hypersensitivity response|delayed-type hypersensitivity http://purl.obolibrary.org/obo/GO_0001806 GO:0001807 biolink:BiologicalProcess regulation of type IV hypersensitivity Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0001807 GO:0001800 biolink:BiologicalProcess negative regulation of type IIb hypersensitivity Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response. go.json down regulation of type IIb hypersensitivity|down-regulation of type IIb hypersensitivity|downregulation of type IIb hypersensitivity|inhibition of type IIb hypersensitivity http://purl.obolibrary.org/obo/GO_0001800 GO:0001801 biolink:BiologicalProcess positive regulation of type IIb hypersensitivity Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response. go.json activation of type IIb hypersensitivity|stimulation of type IIb hypersensitivity|up regulation of type IIb hypersensitivity|up-regulation of type IIb hypersensitivity|upregulation of type IIb hypersensitivity http://purl.obolibrary.org/obo/GO_0001801 GO:0001802 biolink:BiologicalProcess type III hypersensitivity An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue. Wikipedia:Type_III_hypersensitivity go.json http://purl.obolibrary.org/obo/GO_0001802 GO:0001803 biolink:BiologicalProcess regulation of type III hypersensitivity Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0001803 GO:1990950 biolink:BiologicalProcess metaphase/anaphase transition of meiosis II The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II. go.json meiosis II metaphase/anaphase transition|second meiotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1990950 GO:1990951 biolink:BiologicalProcess obsolete manchette assembly OBSOLETE. The assembly and organization of the manchette, a tubular array of microtubules, possibly also containing actin filaments, that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. go.json True http://purl.obolibrary.org/obo/GO_1990951 GO:1990956 biolink:BiologicalProcess fibroblast chemotaxis The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_1990956 GO:1990957 biolink:CellularComponent NPHP complex A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways. go.json NPHP module http://purl.obolibrary.org/obo/GO_1990957 GO:1990958 biolink:BiologicalProcess obsolete response to thyrotropin-releasing hormone OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. go.json response to TRH True http://purl.obolibrary.org/obo/GO_1990958 GO:1990959 biolink:BiologicalProcess eosinophil homeostasis The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json eosinocyte homeostasis|eosinophilic granulocyte homeostasis|eosinophilic leucocyte homeostasis|eosinophilic leukocyte homeostasis http://purl.obolibrary.org/obo/GO_1990959 GO:1990952 biolink:BiologicalProcess obsolete manchette disassembly OBSOLETE. A cellular process that results in the breakdown of a manchette. go.json manchette clearance True http://purl.obolibrary.org/obo/GO_1990952 GO:1990953 biolink:BiologicalProcess intramanchette transport The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments. go.json IMT http://purl.obolibrary.org/obo/GO_1990953 GO:1990954 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990954 GO:1990955 biolink:MolecularActivity G-rich single-stranded DNA binding Binding to G-rich, single-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_1990955 GO:1990960 biolink:BiologicalProcess basophil homeostasis The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json basophilic leucocyte homeostasis http://purl.obolibrary.org/obo/GO_1990960 GO:1990961 biolink:BiologicalProcess xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. go.json drug transmembrane export http://purl.obolibrary.org/obo/GO_1990961 GO:1990962 biolink:BiologicalProcess xenobiotic transport across blood-brain barrier The directed movement of a xenobiotic through the blood-brain barrier. go.json drug transport across blood-brain barrier http://purl.obolibrary.org/obo/GO_1990962 GO:1990967 biolink:BiologicalProcess obsolete multi-organism toxin transport OBSOLETE. The directed movement of a toxin into, out of or within a cell, or between cells where two or more organisms of the same or different species are involved. go.json typhoid toxin transport True http://purl.obolibrary.org/obo/GO_1990967 GO:1990968 biolink:BiologicalProcess modulation by host of RNA binding by virus A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA. go.json modulation by host of viral protein:RNA interaction http://purl.obolibrary.org/obo/GO_1990968 gocheck_do_not_annotate GO:1990969 biolink:BiologicalProcess modulation by host of viral RNA-binding transcription factor activity A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor. go.json modulation by host of viral Tat activity http://purl.obolibrary.org/obo/GO_1990969 GO:1990963 biolink:BiologicalProcess establishment of blood-retinal barrier Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type. go.json establishment of BRB|establishment of blood-retina barrier http://purl.obolibrary.org/obo/GO_1990963 GO:1990964 biolink:CellularComponent actin cytoskeleton-regulatory complex A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat. go.json http://purl.obolibrary.org/obo/GO_1990964 GO:1990965 biolink:MolecularActivity cytosylglucuronate decarboxylase activity Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2. go.json http://purl.obolibrary.org/obo/GO_1990965 GO:1990966 biolink:BiologicalProcess ATP generation from poly-ADP-D-ribose The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. go.json http://purl.obolibrary.org/obo/GO_1990966 GO:1990970 biolink:MolecularActivity trans-activation response element binding Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter. go.json TAR binding http://purl.obolibrary.org/obo/GO_1990970 GO:1990971 biolink:CellularComponent EMILIN complex Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures. go.json EMILIN-1 complex|EMILIN-2 complex|Elastic microfibrillar interface 1 complex|Elastic microfibrillar interface 2 complex http://purl.obolibrary.org/obo/GO_1990971 GO:1990972 biolink:CellularComponent multimerin complex Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures. go.json EMILIN-3 complex|EMILIN-4 complex|Elastic microfibrillar interface 3 complex|Elastic microfibrillar interface 4 complex|Multimerin-1 complex|Multimerin-2 complex|Platelet glycoprotein Ia* complex|p155 complex http://purl.obolibrary.org/obo/GO_1990972 GO:1990973 biolink:CellularComponent transmembrane actin-associated (TAN) line A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge). go.json TAN line http://purl.obolibrary.org/obo/GO_1990973 GO:0050800 biolink:MolecularActivity obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance. go.json hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement True http://purl.obolibrary.org/obo/GO_0050800 GO:0050801 biolink:BiologicalProcess monoatomic ion homeostasis Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. go.json electrolyte homeostasis|ion homeostasis|negative regulation of crystal formation|regulation of ion homeostasis http://purl.obolibrary.org/obo/GO_0050801 GO:0050804 biolink:BiologicalProcess modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. go.json modulation of synaptic transmission|regulation of chemical synaptic transmission|regulation of synaptic transmission http://purl.obolibrary.org/obo/GO_0050804 goslim_synapse GO:0050805 biolink:BiologicalProcess negative regulation of synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. go.json down regulation of synaptic transmission|down-regulation of synaptic transmission|downregulation of synaptic transmission|inhibition of synaptic transmission http://purl.obolibrary.org/obo/GO_0050805 GO:0050802 biolink:BiologicalProcess circadian sleep/wake cycle, sleep The part of the circadian sleep/wake cycle where the organism is asleep. go.json http://purl.obolibrary.org/obo/GO_0050802 GO:0050803 biolink:BiologicalProcess regulation of synapse structure or activity Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). go.json http://purl.obolibrary.org/obo/GO_0050803 GO:0050808 biolink:BiologicalProcess synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). go.json synapse development|synapse morphogenesis|synapse organisation|synapse organization and biogenesis http://purl.obolibrary.org/obo/GO_0050808 goslim_drosophila|goslim_synapse GO:0050809 biolink:MolecularActivity diazepam binding Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium. go.json Valium binding|diazepam binding inhibitor activity http://purl.obolibrary.org/obo/GO_0050809 GO:0050806 biolink:BiologicalProcess positive regulation of synaptic transmission Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. go.json activation of synaptic transmission|stimulation of synaptic transmission|up regulation of synaptic transmission|up-regulation of synaptic transmission|upregulation of synaptic transmission http://purl.obolibrary.org/obo/GO_0050806 GO:0050807 biolink:BiologicalProcess regulation of synapse organization Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). go.json regulation of synapse organisation|regulation of synapse organization and biogenesis|regulation of synapse structure http://purl.obolibrary.org/obo/GO_0050807 goslim_synapse GO:1990978 biolink:BiologicalProcess obsolete response to viscosity OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. go.json True http://purl.obolibrary.org/obo/GO_1990978 GO:1990979 biolink:BiologicalProcess obsolete copper ion transport across blood-brain barrier OBSOLETE. The directed movement of copper ions passing through the blood-brain barrier. go.json copper ion transport across BBB True http://purl.obolibrary.org/obo/GO_1990979 GO:1990974 biolink:BiologicalProcess actin-dependent nuclear migration The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell. go.json actin-dependent nuclear movement http://purl.obolibrary.org/obo/GO_1990974 GO:1990975 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990975 GO:1990976 biolink:BiologicalProcess protein transport along microtubule to mitotic spindle pole body The directed movement of a protein along a microtubule to the mitotic spindle pole body, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_1990976 GO:1990977 biolink:BiologicalProcess obsolete negative regulation of mitotic DNA replication initiation from late origin OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication. go.json True http://purl.obolibrary.org/obo/GO_1990977 GO:1990981 biolink:BiologicalProcess obsolete regulation of protein localization to cell division site involved in cell separation after cytokinesis OBSOLETE. A regulation of protein localization to cell division site involved in cell separation after cytokinesis. go.json True http://purl.obolibrary.org/obo/GO_1990981 GO:1990982 biolink:BiologicalProcess obsolete Immune memory response OBSOLETE. The immune response against a previously encountered antigen being quicker and quantitatively better compared with the primary response. go.json True http://purl.obolibrary.org/obo/GO_1990982 GO:1990983 biolink:BiologicalProcess tRNA demethylation The removal of a methyl group from one or more residues within a tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990983 GO:1990984 biolink:MolecularActivity tRNA demethylase activity Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990984 GO:0050811 biolink:MolecularActivity GABA receptor binding Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. go.json 4-aminobutanoate receptor binding|4-aminobutyrate receptor binding|diazepam binding inhibitor activity|gamma-aminobutyric acid receptor binding http://purl.obolibrary.org/obo/GO_0050811 GO:0050812 biolink:BiologicalProcess regulation of acyl-CoA biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. go.json regulation of acyl-CoA anabolism|regulation of acyl-CoA biosynthesis|regulation of acyl-CoA formation|regulation of acyl-CoA synthesis http://purl.obolibrary.org/obo/GO_0050812 GO:0050810 biolink:BiologicalProcess regulation of steroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. go.json regulation of steroid anabolism|regulation of steroid biosynthesis|regulation of steroid formation|regulation of steroid synthesis|regulation of steroidogenesis http://purl.obolibrary.org/obo/GO_0050810 GO:1990980 biolink:BiologicalProcess obsolete copper ion transport across blood-CSF barrier OBSOLETE. The directed movement of copper ions passing through the blood-cerebrospinal fluid barrier. go.json copper ion transport across BCB|copper ion transport across blood-cerebrospinal fluid barrier True http://purl.obolibrary.org/obo/GO_1990980 GO:0050815 biolink:MolecularActivity phosphoserine residue binding Binding to a phosphorylated serine residue within a protein. go.json phosphoserine binding http://purl.obolibrary.org/obo/GO_0050815 GO:0050816 biolink:MolecularActivity phosphothreonine residue binding Binding to a phosphorylated threonine residue within a protein. go.json phosphothreonine binding http://purl.obolibrary.org/obo/GO_0050816 GO:0050813 biolink:BiologicalProcess epothilone metabolic process The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. go.json epothilone metabolism http://purl.obolibrary.org/obo/GO_0050813 GO:0050814 biolink:BiologicalProcess epothilone biosynthetic process The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. go.json epothilone anabolism|epothilone biosynthesis|epothilone formation|epothilone synthesis http://purl.obolibrary.org/obo/GO_0050814 GO:0050819 biolink:BiologicalProcess negative regulation of coagulation Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. go.json anticoagulant activity|down regulation of coagulation|down-regulation of coagulation|downregulation of coagulation|inhibition of coagulation|negative regulation of clotting http://purl.obolibrary.org/obo/GO_0050819 GO:0050817 biolink:BiologicalProcess coagulation The process in which a fluid solution, or part of it, changes into a solid or semisolid mass. go.json clotting http://purl.obolibrary.org/obo/GO_0050817 goslim_pir GO:0050818 biolink:BiologicalProcess regulation of coagulation Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. go.json regulation of clotting http://purl.obolibrary.org/obo/GO_0050818 GO:1990985 biolink:BiologicalProcess obsolete apoptosis in response to oxidative stress OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to oxidative stress. go.json True http://purl.obolibrary.org/obo/GO_1990985 GO:1990986 biolink:BiologicalProcess DNA recombinase disassembly The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases). go.json Rad51 nucleoprotein filament disassembly http://purl.obolibrary.org/obo/GO_1990986 GO:0001895 biolink:BiologicalProcess retina homeostasis A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. go.json http://purl.obolibrary.org/obo/GO_0001895 GO:0001896 biolink:BiologicalProcess autolysis A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. Wikipedia:Autolysis go.json http://purl.obolibrary.org/obo/GO_0001896 GO:0001897 biolink:BiologicalProcess cytolysis by symbiont of host cells The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json cytolysis by organism of host cells|pathogenesis http://purl.obolibrary.org/obo/GO_0001897 GO:0001898 biolink:BiologicalProcess obsolete regulation of cytolysis by symbiont of host cells OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json regulation by symbiont of cytolysis of host cells True http://purl.obolibrary.org/obo/GO_0001898 GO:0001891 biolink:CellularComponent phagocytic cup An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. go.json http://purl.obolibrary.org/obo/GO_0001891 GO:0001892 biolink:BiologicalProcess embryonic placenta development The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. go.json fetal placenta development http://purl.obolibrary.org/obo/GO_0001892 GO:0001893 biolink:BiologicalProcess maternal placenta development Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. go.json decidua development http://purl.obolibrary.org/obo/GO_0001893 GO:0060190 biolink:BiologicalProcess negative regulation of protein desumoylation Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. go.json http://purl.obolibrary.org/obo/GO_0060190 GO:0001894 biolink:BiologicalProcess tissue homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. go.json tissue maintenance http://purl.obolibrary.org/obo/GO_0001894 GO:0060191 biolink:BiologicalProcess regulation of lipase activity Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. go.json http://purl.obolibrary.org/obo/GO_0060191 gocheck_do_not_annotate GO:0060192 biolink:BiologicalProcess negative regulation of lipase activity Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. go.json http://purl.obolibrary.org/obo/GO_0060192 gocheck_do_not_annotate GO:0060193 biolink:BiologicalProcess positive regulation of lipase activity Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. go.json http://purl.obolibrary.org/obo/GO_0060193 gocheck_do_not_annotate GO:1902379 biolink:MolecularActivity chemoattractant activity involved in axon guidance Any chemoattractant activity that is involved in axon guidance. go.json chemoattractant activity involved in axon chemotaxis|chemoattractant activity involved in axon growth cone guidance|chemoattractant activity involved in axon pathfinding http://purl.obolibrary.org/obo/GO_1902379 GO:0001890 biolink:BiologicalProcess placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. go.json placental development|placentation http://purl.obolibrary.org/obo/GO_0001890 GO:0060194 biolink:BiologicalProcess regulation of antisense RNA transcription Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. go.json http://purl.obolibrary.org/obo/GO_0060194 GO:0060195 biolink:BiologicalProcess negative regulation of antisense RNA transcription Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. go.json http://purl.obolibrary.org/obo/GO_0060195 GO:1902377 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902377 GO:1902378 biolink:BiologicalProcess VEGF-activated neuropilin signaling pathway involved in axon guidance Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance. go.json VEGF-Npn-1 signaling involved in axon chemotaxis|VEGF-Npn-1 signaling involved in axon growth cone guidance|VEGF-Npn-1 signaling involved in axon guidance|VEGF-Npn-1 signaling involved in axon pathfinding|VEGF-activated neuropilin signaling pathway involved in axon chemotaxis|VEGF-activated neuropilin signaling pathway involved in axon growth cone guidance|VEGF-activated neuropilin signaling pathway involved in axon pathfinding|vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon chemotaxis|vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon growth cone guidance|vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon guidance|vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon pathfinding http://purl.obolibrary.org/obo/GO_1902378 GO:0060196 biolink:BiologicalProcess positive regulation of antisense RNA transcription Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. go.json http://purl.obolibrary.org/obo/GO_0060196 GO:1902375 biolink:BiologicalProcess obsolete nuclear tRNA 3'-trailer cleavage, endonucleolytic OBSOLETE. Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus. go.json endonucleolytic tRNA 3'-end cleavage in cell nucleus|endonucleolytic tRNA 3'-end cleavage in nucleus|endonucleolytic tRNA 3'-trailer cleavage in cell nucleus|endonucleolytic tRNA 3'-trailer cleavage in nucleus|tRNA 3'-end cleavage, endonucleolytic in cell nucleus|tRNA 3'-end cleavage, endonucleolytic in nucleus|tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus True http://purl.obolibrary.org/obo/GO_1902375 GO:0060197 biolink:BiologicalProcess cloacal septation The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development. go.json cloaca septation http://purl.obolibrary.org/obo/GO_0060197 GO:1902376 biolink:BiologicalProcess obsolete protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process OBSOLETE. Any protein denaturation that is involved in proteasomal ubiquitin-dependent protein catabolic process. go.json protein denaturation involved in proteasomal pathway|protein denaturation involved in proteasomal processing|protein denaturation involved in proteasomal ubiquitin-dependent protein breakdown|protein denaturation involved in proteasomal ubiquitin-dependent protein catabolism|protein denaturation involved in proteasomal ubiquitin-dependent protein degradation|protein denaturation involved in proteasome pathway True http://purl.obolibrary.org/obo/GO_1902376 GO:0060198 biolink:CellularComponent clathrin-sculpted vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. go.json clathrin sculpted vesicle http://purl.obolibrary.org/obo/GO_0060198 GO:1902384 biolink:BiologicalProcess glycyrrhetinate metabolic process The chemical reactions and pathways involving glycyrrhetinate. go.json glycyrrhetinate metabolism http://purl.obolibrary.org/obo/GO_1902384 GO:0060199 biolink:CellularComponent clathrin-sculpted glutamate transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate. go.json clathrin sculpted glutamate constitutive secretory pathway transport vesicle|clathrin sculpted glutamate transport vesicle http://purl.obolibrary.org/obo/GO_0060199 GO:1902385 biolink:BiologicalProcess glycyrrhetinate catabolic process The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate. go.json glycyrrhetinate breakdown|glycyrrhetinate catabolism|glycyrrhetinate degradation http://purl.obolibrary.org/obo/GO_1902385 GO:1902382 biolink:BiologicalProcess 11-oxo-beta-amyrin catabolic process The chemical reactions and pathways resulting in the breakdown of 11-oxo-beta-amyrin. go.json 11-oxo-beta-amyrin breakdown|11-oxo-beta-amyrin catabolism|11-oxo-beta-amyrin degradation http://purl.obolibrary.org/obo/GO_1902382 GO:1902383 biolink:BiologicalProcess 11-oxo-beta-amyrin biosynthetic process The chemical reactions and pathways resulting in the formation of 11-oxo-beta-amyrin. go.json 11-oxo-beta-amyrin anabolism|11-oxo-beta-amyrin biosynthesis|11-oxo-beta-amyrin formation|11-oxo-beta-amyrin synthesis http://purl.obolibrary.org/obo/GO_1902383 GO:1902380 biolink:BiologicalProcess positive regulation of endoribonuclease activity Any process that activates or increases the frequency, rate or extent of endoribonuclease activity. go.json activation of endonuclease G activity|activation of endoribonuclease activity|positive regulation of endonuclease G activity|up regulation of endonuclease G activity|up regulation of endoribonuclease activity|up-regulation of endonuclease G activity|up-regulation of endoribonuclease activity|upregulation of endonuclease G activity|upregulation of endoribonuclease activity http://purl.obolibrary.org/obo/GO_1902380 gocheck_do_not_annotate GO:1990916 biolink:CellularComponent Isp3 layer of spore wall The outermost layers of the spore wall, as described in Schizosaccharomyces pombe. go.json http://purl.obolibrary.org/obo/GO_1990916 GO:1990917 biolink:CellularComponent ooplasm The cytoplasm of an ovum. go.json http://purl.obolibrary.org/obo/GO_1990917 GO:1902381 biolink:BiologicalProcess 11-oxo-beta-amyrin metabolic process The chemical reactions and pathways involving 11-oxo-beta-amyrin. go.json 11-oxo-beta-amyrin metabolism http://purl.obolibrary.org/obo/GO_1902381 GO:1990918 biolink:BiologicalProcess double-strand break repair involved in meiotic recombination The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. go.json http://purl.obolibrary.org/obo/GO_1990918 GO:1990919 biolink:MolecularActivity proteasome-nuclear membrane anchor activity The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome. go.json nuclear membrane proteasome adaptor|nuclear membrane proteasome anchor|nuclear membrane proteasome tether|nuclear membrane proteasome tether activity|nuclear membrane-proteasome anchor activity|nuclear membrane-proteasome tether activity|tethering factor for nuclear proteasome http://purl.obolibrary.org/obo/GO_1990919 GO:1990912 biolink:BiologicalProcess obsolete response to microwave radiation OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus. go.json True http://purl.obolibrary.org/obo/GO_1990912 GO:1990913 biolink:CellularComponent sperm head plasma membrane The plasma membrane that is part of the head section of a sperm cell. go.json http://purl.obolibrary.org/obo/GO_1990913 GO:1990914 biolink:CellularComponent obsolete integral component of periplasmic side of plasma membrane OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane. go.json True http://purl.obolibrary.org/obo/GO_1990914 GO:1990915 biolink:MolecularActivity structural constituent of ascospore wall The action of a molecule that contributes to the structural integrity of an ascospore wall. go.json http://purl.obolibrary.org/obo/GO_1990915 GO:0001899 biolink:BiologicalProcess obsolete negative regulation of cytolysis by symbiont of host cells OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of cytolysis of host cells|down-regulation by symbiont of cytolysis of host cells|downregulation by symbiont of cytolysis of host cells|inhibition by symbiont of cytolysis of host cells|negative regulation by symbiont of cytolysis of host cells True http://purl.obolibrary.org/obo/GO_0001899 GO:1990910 biolink:BiologicalProcess response to hypobaric hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level). go.json http://purl.obolibrary.org/obo/GO_1990910 GO:1990911 biolink:BiologicalProcess response to psychosocial stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. go.json http://purl.obolibrary.org/obo/GO_1990911 GO:0060180 biolink:BiologicalProcess female mating behavior The specific behavior of a female organism that is associated with reproduction. go.json http://purl.obolibrary.org/obo/GO_0060180 GO:0060181 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060181 GO:0060182 biolink:MolecularActivity apelin receptor activity Combining with the peptide apelin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0060182 GO:0060183 biolink:BiologicalProcess apelin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by apelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json apelin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060183 GO:1902388 biolink:MolecularActivity ceramide 1-phosphate transfer activity Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Reactome:R-HSA-5339535 go.json ceramide 1-phosphate carrier activity|ceramide 1-phosphate transporter activity|intermembrane ceramide 1-phosphate transfer activity http://purl.obolibrary.org/obo/GO_1902388 GO:0060184 biolink:BiologicalProcess cell cycle switching The process in which a cell switches cell cycle mode. go.json http://purl.obolibrary.org/obo/GO_0060184 GO:1902389 biolink:BiologicalProcess ceramide 1-phosphate transport The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1902389 GO:0060185 biolink:BiologicalProcess outer ear unfolding The opening and spreading out of the outer ear. go.json http://purl.obolibrary.org/obo/GO_0060185 GO:1902386 biolink:BiologicalProcess glycyrrhetinate biosynthetic process The chemical reactions and pathways resulting in the formation of glycyrrhetinate. go.json glycyrrhetinate anabolism|glycyrrhetinate biosynthesis|glycyrrhetinate formation|glycyrrhetinate synthesis http://purl.obolibrary.org/obo/GO_1902386 GO:0060186 biolink:BiologicalProcess outer ear emergence The growth of the outer ear. go.json ear elevation|ear extroversion|outer ear growth http://purl.obolibrary.org/obo/GO_0060186 GO:1902387 biolink:MolecularActivity ceramide 1-phosphate binding Binding to ceramide 1-phosphate. go.json http://purl.obolibrary.org/obo/GO_1902387 GO:0060187 biolink:CellularComponent cell pole Either of two different areas at opposite ends of an axis of a cell. go.json http://purl.obolibrary.org/obo/GO_0060187 GO:1902395 biolink:BiologicalProcess regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity Any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity. go.json regulation of 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity|regulation of 1-deoxyxylulose-5-phosphate synthase activity|regulation of DOXP synthase activity|regulation of DXP-synthase activity|regulation of pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating) http://purl.obolibrary.org/obo/GO_1902395 gocheck_do_not_annotate GO:0060188 biolink:BiologicalProcess regulation of protein desumoylation Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. go.json http://purl.obolibrary.org/obo/GO_0060188 GO:1902396 biolink:BiologicalProcess protein localization to bicellular tight junction A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction. go.json protein localisation in tight junction|protein localisation to tight junction|protein localization in tight junction http://purl.obolibrary.org/obo/GO_1902396 GO:0060189 biolink:BiologicalProcess positive regulation of protein desumoylation Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. go.json http://purl.obolibrary.org/obo/GO_0060189 GO:1902393 biolink:BiologicalProcess negative regulation of exodeoxyribonuclease activity Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity. go.json down regulation of exodeoxyribonuclease activity|down-regulation of exodeoxyribonuclease activity|downregulation of exodeoxyribonuclease activity|inhibition of exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_1902393 gocheck_do_not_annotate GO:1902394 biolink:BiologicalProcess positive regulation of exodeoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of exodeoxyribonuclease activity. go.json activation of exodeoxyribonuclease activity|up regulation of exodeoxyribonuclease activity|up-regulation of exodeoxyribonuclease activity|upregulation of exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_1902394 gocheck_do_not_annotate GO:1902391 biolink:BiologicalProcess positive regulation of N-terminal peptidyl-serine acetylation Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation. go.json activation of N-terminal peptidyl-serine acetylation|up regulation of N-terminal peptidyl-serine acetylation|up-regulation of N-terminal peptidyl-serine acetylation|upregulation of N-terminal peptidyl-serine acetylation http://purl.obolibrary.org/obo/GO_1902391 GO:1990927 biolink:BiologicalProcess calcium ion regulated lysosome exocytosis The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. go.json http://purl.obolibrary.org/obo/GO_1990927 GO:1990928 biolink:BiologicalProcess response to amino acid starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. go.json http://purl.obolibrary.org/obo/GO_1990928 GO:1902392 biolink:BiologicalProcess regulation of exodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of exodeoxyribonuclease activity. go.json http://purl.obolibrary.org/obo/GO_1902392 gocheck_do_not_annotate GO:1990929 biolink:MolecularActivity sulfoquinovosidase activity Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose. go.json http://purl.obolibrary.org/obo/GO_1990929 GO:1902390 biolink:BiologicalProcess regulation of N-terminal peptidyl-serine acetylation Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation. go.json http://purl.obolibrary.org/obo/GO_1902390 GO:1990923 biolink:CellularComponent PET complex A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs. go.json http://purl.obolibrary.org/obo/GO_1990923 GO:1990924 biolink:CellularComponent obsolete amphisome membrane OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm. go.json amphisomal membrane True http://purl.obolibrary.org/obo/GO_1990924 GO:1990925 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990925 GO:1990926 biolink:BiologicalProcess short-term synaptic potentiation The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds. go.json synaptic facilitation http://purl.obolibrary.org/obo/GO_1990926 GO:1990920 biolink:BiologicalProcess obsolete proteasome localization to nuclear periphery OBSOLETE. Any process in which the proteasome is transported to, or maintained at the nuclear periphery. go.json True http://purl.obolibrary.org/obo/GO_1990920 GO:1990921 biolink:BiologicalProcess obsolete proteasome localization to nuclear periphery OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery. go.json proteasome localisation to nuclear periphery True http://purl.obolibrary.org/obo/GO_1990921 GO:1990922 biolink:BiologicalProcess hepatic stellate cell proliferation The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver. go.json Ito cell proliferation|hepatic perisinusoidal cell proliferation|perisinusoidal cell proliferation http://purl.obolibrary.org/obo/GO_1990922 GO:0001873 biolink:MolecularActivity polysaccharide immune receptor activity Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json polysaccharide receptor activity http://purl.obolibrary.org/obo/GO_0001873 GO:0098785 biolink:BiologicalProcess biofilm matrix assembly A process that results in the assembly of a biofilm matrix. go.json http://purl.obolibrary.org/obo/GO_0098785 GO:0001874 biolink:MolecularActivity (1->3)-beta-D-glucan immune receptor activity Combining with (1->3)-beta-D-glucans to initiate an innate immune response. go.json (1,3)-beta-D-glucan receptor activity|(1->3)-beta-D-glucan receptor activity|1,3-beta-D-glucan receptor activity|beta-1,3-D-glucan receptor activity|zymosan receptor activity http://purl.obolibrary.org/obo/GO_0001874 GO:0098786 biolink:BiologicalProcess biofilm matrix disassembly A process that results in the disassembly of a biofilm matrix. go.json http://purl.obolibrary.org/obo/GO_0098786 GO:0098783 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098783 GO:0001875 biolink:MolecularActivity lipopolysaccharide immune receptor activity Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. go.json LPS receptor activity|endotoxin receptor activity|lipopolysaccharide receptor activity http://purl.obolibrary.org/obo/GO_0001875 GO:0001876 biolink:MolecularActivity lipoarabinomannan binding Binding to lipoarabinomannan. go.json LAM binding http://purl.obolibrary.org/obo/GO_0001876 GO:0098784 biolink:BiologicalProcess biofilm matrix organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix. go.json biofilm matrix organization and biogenesis http://purl.obolibrary.org/obo/GO_0098784 GO:0098781 biolink:BiologicalProcess ncRNA transcription The transcription of non (protein) coding RNA from a DNA template. go.json http://purl.obolibrary.org/obo/GO_0098781 GO:0098782 biolink:MolecularActivity mechanosensitived potassium channel activity Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress. go.json mechanically-gated potassium channel activity http://purl.obolibrary.org/obo/GO_0098782 GO:0001870 biolink:BiologicalProcess positive regulation of complement activation, lectin pathway Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway. go.json activation of complement activation, lectin pathway|positive regulation of complement cascade, lectin pathway|stimulation of complement activation, lectin pathway|up regulation of complement activation, lectin pathway|up-regulation of complement activation, lectin pathway|upregulation of complement activation, lectin pathway http://purl.obolibrary.org/obo/GO_0001870 GO:0001871 biolink:MolecularActivity obsolete pattern binding OBSOLETE. Binding to a repeating or polymeric structure, such as a polysaccharide or peptidoglycan. go.json pattern recognition activity True http://purl.obolibrary.org/obo/GO_0001871 GO:0001872 biolink:MolecularActivity (1->3)-beta-D-glucan binding Binding to a (1->3)-beta-D-glucan. go.json 1,3-beta-D-glucan binding|callose binding|zymosan binding http://purl.obolibrary.org/obo/GO_0001872 GO:0098780 biolink:BiologicalProcess response to mitochondrial depolarisation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. go.json http://purl.obolibrary.org/obo/GO_0098780 GO:1902399 biolink:BiologicalProcess obsolete detection of stimulus involved in G1 DNA damage checkpoint OBSOLETE. Any detection of stimulus that is involved in G1 DNA damage checkpoint. go.json detection of stimulus involved in G1/S DNA damage checkpoint|perception of stimulus involved in G1 DNA damage checkpoint|perception of stimulus involved in G1/S DNA damage checkpoint|stimulus detection involved in G1 DNA damage checkpoint|stimulus detection involved in G1/S DNA damage checkpoint|stimulus sensing involved in G1 DNA damage checkpoint|stimulus sensing involved in G1/S DNA damage checkpoint True http://purl.obolibrary.org/obo/GO_1902399 GO:1902397 biolink:BiologicalProcess obsolete detection of stimulus involved in meiotic spindle checkpoint OBSOLETE. Any detection of stimulus that is involved in meiotic spindle checkpoint. go.json perception of stimulus involved in meiotic spindle checkpoint|stimulus detection involved in meiotic spindle checkpoint|stimulus sensing involved in meiotic spindle checkpoint True http://purl.obolibrary.org/obo/GO_1902397 GO:1902398 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902398 GO:1990938 biolink:BiologicalProcess peptidyl-aspartic acid autophosphorylation The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein. go.json aspartyl autophosphorylation|peptidyl-aspartate autophosphorylation http://purl.obolibrary.org/obo/GO_1990938 gocheck_do_not_annotate GO:1990939 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990939 GO:1990934 biolink:CellularComponent nucleolus-like body A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles. go.json NLB|compact nucleolus http://purl.obolibrary.org/obo/GO_1990934 GO:1990935 biolink:MolecularActivity splicing factor binding Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA. go.json http://purl.obolibrary.org/obo/GO_1990935 GO:1990936 biolink:BiologicalProcess vascular associated smooth muscle cell dedifferentiation The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. go.json vascular smooth muscle cell dedifferentiation http://purl.obolibrary.org/obo/GO_1990936 GO:1990937 biolink:BiologicalProcess xylan acetylation The addition of one or more acetyl groups to a xylan molecule. go.json http://purl.obolibrary.org/obo/GO_1990937 GO:0098789 biolink:BiologicalProcess obsolete pre-mRNA cleavage required for polyadenylation OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation. go.json cleavage and polyadenylylation specificity factor activity|pre-mRNA cleavage factor activity True http://purl.obolibrary.org/obo/GO_0098789 GO:0001877 biolink:MolecularActivity lipoarabinomannan immune receptor activity Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response. go.json LAM receptor activity|lipoarabinomannan receptor activity http://purl.obolibrary.org/obo/GO_0001877 GO:1990930 biolink:MolecularActivity mRNA N1-methyladenosine dioxygenase activity Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde. EC:1.14.11.54|RHEA:49516 go.json RNA N(1)-methyladenosine dioxygenase activity|RNA N1-methyladenosine dioxygenase activity http://purl.obolibrary.org/obo/GO_1990930 GO:0001878 biolink:BiologicalProcess response to yeast Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. go.json http://purl.obolibrary.org/obo/GO_0001878 GO:1990931 biolink:MolecularActivity mRNA N6-methyladenosine dioxygenase activity Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. EC:1.14.11.53|RHEA:49520 go.json RNA N6-methyladenosine dioxygenase activity|mRNA N(6)-methyladenine demethylase|mRNA N(6)-methyladenosine dioxygenase activity http://purl.obolibrary.org/obo/GO_1990931 GO:1990932 biolink:MolecularActivity 5.8S rRNA binding Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA. go.json http://purl.obolibrary.org/obo/GO_1990932 GO:0098787 biolink:BiologicalProcess obsolete mRNA cleavage involved in mRNA processing OBSOLETE. Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide. go.json True http://purl.obolibrary.org/obo/GO_0098787 GO:0001879 biolink:BiologicalProcess detection of yeast The series of events in which a stimulus from a yeast is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0001879 GO:1990933 biolink:BiologicalProcess microtubule cytoskeleton attachment to nuclear envelope A process in which the microtubule cytoskeleton is attached to the nuclear envelope. go.json http://purl.obolibrary.org/obo/GO_1990933 GO:0098788 biolink:CellularComponent dendritic knob The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium. go.json apical dendritic knob http://purl.obolibrary.org/obo/GO_0098788 GO:0001884 biolink:MolecularActivity pyrimidine nucleoside binding Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0001884 GO:0098796 biolink:CellularComponent membrane protein complex Any protein complex that is part of a membrane. go.json http://purl.obolibrary.org/obo/GO_0098796 goslim_metagenomics GO:0001885 biolink:BiologicalProcess endothelial cell development The progression of an endothelial cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0001885 GO:0098797 biolink:CellularComponent plasma membrane protein complex Any protein complex that is part of the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0098797 GO:0001886 biolink:BiologicalProcess endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0001886 GO:0098794 biolink:CellularComponent postsynapse The part of a synapse that is part of the post-synaptic cell. go.json http://purl.obolibrary.org/obo/GO_0098794 goslim_synapse GO:0098795 biolink:BiologicalProcess global gene silencing by mRNA cleavage A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner. go.json RNA interference, targeting of mRNA for destruction|gene silencing by mRNA cleavage|mRNA cleavage involved in gene silencing|mRNA destabilization-mediated gene silencing|targeting of mRNA for destruction involved in RNA interference http://purl.obolibrary.org/obo/GO_0098795 GO:1990940 biolink:BiologicalProcess obsolete microtubule sliding involved in mitotic spindle elongation OBSOLETE. The movement of one microtubule along another microtubule involved in mitotic spindle elongation. go.json True http://purl.obolibrary.org/obo/GO_1990940 GO:0001887 biolink:BiologicalProcess selenium compound metabolic process The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine. go.json selenium compound metabolism|selenium metabolic process|selenium metabolism http://purl.obolibrary.org/obo/GO_0001887 GO:0098792 biolink:BiologicalProcess xenophagy The selective degradation of intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0098792 GO:0001880 biolink:BiologicalProcess Mullerian duct regression The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos. go.json http://purl.obolibrary.org/obo/GO_0001880 GO:0098793 biolink:CellularComponent presynapse The part of a synapse that is part of the presynaptic cell. go.json presynaptic terminal http://purl.obolibrary.org/obo/GO_0098793 goslim_synapse GO:0001881 biolink:BiologicalProcess receptor recycling The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal. go.json http://purl.obolibrary.org/obo/GO_0001881 GO:0001882 biolink:MolecularActivity nucleoside binding Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0001882 goslim_pir GO:0098790 biolink:BiologicalProcess ncRNA transcription associated with protein coding gene TSS/TES The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes. go.json pasRNA transcription http://purl.obolibrary.org/obo/GO_0098790 GO:0001883 biolink:MolecularActivity purine nucleoside binding Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0001883 GO:0098791 biolink:CellularComponent Golgi apparatus subcompartment A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus. go.json Golgi subcompartment http://purl.obolibrary.org/obo/GO_0098791 GO:1990949 biolink:BiologicalProcess metaphase/anaphase transition of meiosis I The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I. go.json first meiotic metaphase/anaphase transition|meiosis I metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_1990949 GO:1990945 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990945 GO:1990946 biolink:BiologicalProcess meiosis I/meiosis II transition The cell cycle process in which a cell progresses from meiosis I to meiosis II. go.json http://purl.obolibrary.org/obo/GO_1990946 GO:1990947 biolink:BiologicalProcess exit from meiosis Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half. go.json meiotic exit http://purl.obolibrary.org/obo/GO_1990947 GO:1990948 biolink:MolecularActivity ubiquitin ligase inhibitor activity Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. go.json APC-Cdc20 complex inhibitor activity|mitotic anaphase-promoting complex inhibitor activity http://purl.obolibrary.org/obo/GO_1990948 GO:0001888 biolink:MolecularActivity glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. EC:2.4.1.223|MetaCyc:2.4.1.223-RXN|RHEA:16221 go.json UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity|alpha-1,4-N-acetylglucosaminyltransferase activity|alpha-N-acetylglucosaminyltransferase I activity|alpha1,4-N-acetylglucosaminyltransferase activity|glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0001888 GO:1990941 biolink:CellularComponent mitotic spindle kinetochore microtubule Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation. go.json http://purl.obolibrary.org/obo/GO_1990941 GO:1990942 biolink:BiologicalProcess mitotic metaphase chromosome recapture A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate. go.json kinetochore retrieval|metaphase chromosome retrieval to the spindle pole body|microtubule sliding involved in kinetochore retrieval|microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body|microtubule sliding involved in mitotic metaphase chromosome recapture|microtubule sliding involved in sister kinetochore recapture|sister kinetochore recapture http://purl.obolibrary.org/obo/GO_1990942 GO:0001889 biolink:BiologicalProcess liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. go.json http://purl.obolibrary.org/obo/GO_0001889 GO:0098798 biolink:CellularComponent mitochondrial protein-containing complex A protein complex that is part of a mitochondrion. go.json mitochondrial protein complex http://purl.obolibrary.org/obo/GO_0098798 gocheck_do_not_manually_annotate GO:1990943 biolink:MolecularActivity mating type region replication fork barrier binding Binding to the replication fork barrier found in the mating type region of fission yeast. go.json RTS1 barrier binding|RTS1 element binding http://purl.obolibrary.org/obo/GO_1990943 GO:0098799 biolink:CellularComponent outer mitochondrial membrane protein complex Any protein complex that is part of the outer mitochondrial membrane. go.json http://purl.obolibrary.org/obo/GO_0098799 GO:1990944 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990944 GO:0001851 biolink:MolecularActivity complement component C3b binding Binding to a C3b product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001851 GO:0001852 biolink:MolecularActivity complement component iC3b binding Binding to a iC3b product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001852 GO:0001853 biolink:MolecularActivity complement component C3dg binding Binding to a C3dg product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001853 GO:0001854 biolink:MolecularActivity complement component C3d binding Binding to a C3d product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001854 GO:0001850 biolink:MolecularActivity complement component C3a binding Binding to a C3a product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001850 GO:0001859 biolink:MolecularActivity complement component C3dg receptor activity Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001859 GO:0001855 biolink:MolecularActivity complement component C4b binding Binding to a C4b product of the classical complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001855 GO:0001856 biolink:MolecularActivity complement component C5a binding Binding to a C5a product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001856 GO:0001857 biolink:MolecularActivity complement component C1q receptor activity Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001857 GO:0001858 biolink:MolecularActivity complement component iC3b receptor activity Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001858 GO:0001862 biolink:MolecularActivity collectin binding Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus. go.json http://purl.obolibrary.org/obo/GO_0001862 GO:0001863 biolink:MolecularActivity collectin receptor activity Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001863 GO:0001864 biolink:MolecularActivity pentraxin binding Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array. go.json http://purl.obolibrary.org/obo/GO_0001864 GO:0001865 biolink:BiologicalProcess NK T cell differentiation The process in which a precursor cell type acquires the specialized features of a NK T cell. go.json NK T cell development|NK T lymphocyte differentiation|NK T-cell differentiation|NK T-lymphocyte differentiation|NKT cell differentiation|NT cell differentiation|natural T cell differentiation|natural killer T cell differentiation http://purl.obolibrary.org/obo/GO_0001865 GO:0001860 biolink:MolecularActivity complement component C3d receptor activity Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001860 GO:0001861 biolink:MolecularActivity complement component C4b receptor activity Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001861 GO:0001866 biolink:BiologicalProcess NK T cell proliferation The expansion of a NK T cell population by cell division. go.json NK T lymphocyte proliferation|NK T-cell proliferation|NK T-lymphocyte proliferation|NKT cell proliferation|NT cell proliferation|natural T cell proliferation|natural killer T cell proliferation http://purl.obolibrary.org/obo/GO_0001866 GO:0001867 biolink:BiologicalProcess complement activation, lectin pathway Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. go.json complement cascade, lectin pathway http://purl.obolibrary.org/obo/GO_0001867 GO:0001868 biolink:BiologicalProcess regulation of complement activation, lectin pathway Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation. go.json regulation of complement cascade, lectin pathway http://purl.obolibrary.org/obo/GO_0001868 GO:0001869 biolink:BiologicalProcess negative regulation of complement activation, lectin pathway Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway. go.json down regulation of complement activation, lectin pathway|down-regulation of complement activation, lectin pathway|downregulation of complement activation, lectin pathway|inhibition of complement activation, lectin pathway|negative regulation of complement cascade, lectin pathway http://purl.obolibrary.org/obo/GO_0001869 GO:0001830 biolink:BiologicalProcess trophectodermal cell fate commitment The cell fate commitment of precursor cells that will become trophectoderm cells. go.json trophectoderm cell fate commitment http://purl.obolibrary.org/obo/GO_0001830 GO:0001831 biolink:BiologicalProcess trophectodermal cellular morphogenesis The morphogenesis of trophectoderm cells. go.json trophectoderm cellular morphogenesis http://purl.obolibrary.org/obo/GO_0001831 GO:0001832 biolink:BiologicalProcess blastocyst growth An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0001832 GO:0001837 biolink:BiologicalProcess epithelial to mesenchymal transition A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json EMT|epithelial-mesenchymal transition|mesenchymal cell differentiation from epithelial cell http://purl.obolibrary.org/obo/GO_0001837 GO:0001838 biolink:BiologicalProcess embryonic epithelial tube formation The morphogenesis of an embryonic epithelium into a tube-shaped structure. go.json http://purl.obolibrary.org/obo/GO_0001838 GO:0001839 biolink:BiologicalProcess neural plate morphogenesis The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. go.json http://purl.obolibrary.org/obo/GO_0001839 GO:0001833 biolink:BiologicalProcess inner cell mass cell proliferation The proliferation of cells in the inner cell mass. go.json http://purl.obolibrary.org/obo/GO_0001833 GO:0001834 biolink:BiologicalProcess trophectodermal cell proliferation The proliferation of cells in the trophectoderm. go.json trophectoderm cell proliferation http://purl.obolibrary.org/obo/GO_0001834 GO:0001835 biolink:BiologicalProcess blastocyst hatching The hatching of the cellular blastocyst from the zona pellucida. go.json http://purl.obolibrary.org/obo/GO_0001835 GO:0001836 biolink:BiologicalProcess release of cytochrome c from mitochondria The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. go.json http://purl.obolibrary.org/obo/GO_0001836 GO:0001840 biolink:BiologicalProcess neural plate development The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0001840 GO:0001841 biolink:BiologicalProcess neural tube formation The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. Wikipedia:Neurulation go.json neural tube morphogenesis|neurulation http://purl.obolibrary.org/obo/GO_0001841 GO:0001842 biolink:BiologicalProcess neural fold formation The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. go.json neural groove formation http://purl.obolibrary.org/obo/GO_0001842 GO:0001843 biolink:BiologicalProcess neural tube closure The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. go.json http://purl.obolibrary.org/obo/GO_0001843 GO:1990909 biolink:CellularComponent Wnt signalosome A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. go.json LRP5/6 signalosome|LRP6 signalosome|Wnt signalosome complex|Wnt-LRP5/6 signalosome http://purl.obolibrary.org/obo/GO_1990909 GO:1990905 biolink:CellularComponent dinoflagellate peduncle A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy). go.json http://purl.obolibrary.org/obo/GO_1990905 GO:1990906 biolink:CellularComponent accessory outer segment A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors. go.json http://purl.obolibrary.org/obo/GO_1990906 GO:1990907 biolink:CellularComponent beta-catenin-TCF complex A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. go.json beta-catenin/LEF complex|beta-catenin/T-cell factor complex|beta-catenin/lymphoid enhancer binding factor complex http://purl.obolibrary.org/obo/GO_1990907 GO:1990908 biolink:MolecularActivity obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile. go.json True http://purl.obolibrary.org/obo/GO_1990908 GO:0001848 biolink:MolecularActivity complement binding Binding to a component or product of the complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001848 GO:1990901 biolink:CellularComponent old cell pole The cell pole distal from the most recent cell division. go.json http://purl.obolibrary.org/obo/GO_1990901 GO:0001849 biolink:MolecularActivity complement component C1q complex binding Binding to a C1q complex, a component of the classical complement cascade. go.json http://purl.obolibrary.org/obo/GO_0001849 GO:1990902 biolink:CellularComponent new cell pole The cell pole proximal to the most recent cell division. go.json http://purl.obolibrary.org/obo/GO_1990902 GO:1990903 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990903 GO:1990904 biolink:CellularComponent ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules. Wikipedia:Ribonucleoprotein go.json RNA-protein complex|RNP|extracellular ribonucleoprotein complex|intracellular ribonucleoprotein complex|protein-RNA complex http://purl.obolibrary.org/obo/GO_1990904 goslim_pir GO:0001844 biolink:BiologicalProcess protein insertion into mitochondrial membrane involved in apoptotic signaling pathway The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway. go.json insertion of proteins into mitochondrial membranes during the induction of apoptosis|protein insertion into mitochondrial membrane during induction of apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|protein insertion into mitochondrion membrane during induction of apoptosis http://purl.obolibrary.org/obo/GO_0001844 GO:0001845 biolink:BiologicalProcess phagolysosome assembly The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. go.json late phagosome biosynthesis|late phagosome formation|phagolysosome formation http://purl.obolibrary.org/obo/GO_0001845 GO:0001846 biolink:MolecularActivity opsonin binding Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. go.json http://purl.obolibrary.org/obo/GO_0001846 GO:1990900 biolink:CellularComponent ciliary pocket collar A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma. go.json FPC|cilium pocket collar|flagellar collar|flagellar pocket collar|flagellar pore|flagellum pocket collar http://purl.obolibrary.org/obo/GO_1990900 GO:0001847 biolink:MolecularActivity opsonin receptor activity Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001847 GO:0050785 biolink:MolecularActivity advanced glycation end-product receptor activity Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins). go.json AGE receptor activity|RAGE activity http://purl.obolibrary.org/obo/GO_0050785 GO:0098720 biolink:BiologicalProcess succinate import across plasma membrane The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol. go.json succinate import into cell http://purl.obolibrary.org/obo/GO_0098720 GO:0050786 biolink:MolecularActivity RAGE receptor binding Binding to a RAGE receptor, the receptor for advanced glycation end-products. go.json advanced glycation end-product receptor binding http://purl.obolibrary.org/obo/GO_0050786 GO:0050783 biolink:BiologicalProcess cocaine metabolic process The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. go.json cocaine metabolism http://purl.obolibrary.org/obo/GO_0050783 GO:0050784 biolink:BiologicalProcess cocaine catabolic process The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. go.json cocaine breakdown|cocaine catabolism|cocaine degradation http://purl.obolibrary.org/obo/GO_0050784 GO:0050789 biolink:BiologicalProcess regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. go.json regulation of physiological process http://purl.obolibrary.org/obo/GO_0050789 gocheck_do_not_annotate|goslim_candida|goslim_pir GO:0050787 biolink:BiologicalProcess detoxification of mercury ion Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0]). go.json http://purl.obolibrary.org/obo/GO_0050787 GO:0050788 biolink:BiologicalProcess sequestering of mercury The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system. go.json mercuric ion (Hg2+) sequestering|mercuric ion (Hg2+) sequestration|mercury (Hg) ion sequestering|mercury (Hg) ion sequestration|mercury (Hg2+) ion retention|mercury (Hg2+) ion storage|retention of mercury (Hg2+) ion|sequestering of mercuric ion (Hg2+)|sequestering of mercury (Hg) ion|sequestration of mercuric ion (Hg2+)|sequestration of mercury (Hg) ion|storage of mercury (Hg2+) ion http://purl.obolibrary.org/obo/GO_0050788 GO:2001314 biolink:BiologicalProcess UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolic process The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. go.json UDP-4-deoxy-4-formamido-beta-L-arabinopyranose breakdown|UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolism|UDP-4-deoxy-4-formamido-beta-L-arabinopyranose degradation http://purl.obolibrary.org/obo/GO_2001314 GO:2001315 biolink:BiologicalProcess UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. go.json UDP-4-deoxy-4-formamido-beta-L-arabinopyranose anabolism|UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthesis|UDP-4-deoxy-4-formamido-beta-L-arabinopyranose formation|UDP-4-deoxy-4-formamido-beta-L-arabinopyranose synthesis http://purl.obolibrary.org/obo/GO_2001315 GO:2001316 biolink:BiologicalProcess kojic acid metabolic process The chemical reactions and pathways involving kojic acid. go.json 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolic process|5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolism|C6H6O4 metabolic process|C6H6O4 metabolism|kojic acid metabolism http://purl.obolibrary.org/obo/GO_2001316 GO:2001317 biolink:BiologicalProcess kojic acid biosynthetic process The chemical reactions and pathways resulting in the formation of kojic acid. go.json 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|C6H6O4 anabolism|C6H6O4 biosynthesis|C6H6O4 biosynthetic process|C6H6O4 formation|C6H6O4 synthesis|kojic acid anabolism|kojic acid biosynthesis|kojic acid formation|kojic acid synthesis http://purl.obolibrary.org/obo/GO_2001317 GO:0060110 biolink:CellularComponent basal layer of collagen and cuticulin-based cuticle extracellular matrix The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans. go.json basal layer of collagen and cuticulin-based exoskeleton extracellular matrix http://purl.obolibrary.org/obo/GO_0060110 GO:0035144 biolink:BiologicalProcess anal fin morphogenesis The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. go.json http://purl.obolibrary.org/obo/GO_0035144 GO:0060111 biolink:CellularComponent alae of collagen and cuticulin-based cuticle extracellular matrix Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively. go.json alae of collagen and cuticulin-based exoskeleton extracellular matrix http://purl.obolibrary.org/obo/GO_0060111 GO:0035145 biolink:CellularComponent exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. go.json EJC|exon junction complex http://purl.obolibrary.org/obo/GO_0035145 GO:0060112 biolink:BiologicalProcess generation of ovulation cycle rhythm The process which controls the timing of the type of sexual cycle seen in female mammals. go.json generation of estrus cycle rhythm|generation of menstrual cycle rhythm|generation of oestrus cycle rhythm http://purl.obolibrary.org/obo/GO_0060112 GO:0060113 biolink:BiologicalProcess inner ear receptor cell differentiation The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound. go.json inner ear hair cell differentiation http://purl.obolibrary.org/obo/GO_0060113 GO:0035146 biolink:BiologicalProcess tube fusion The joining of specific branches of a tubular system to form a continuous network. go.json http://purl.obolibrary.org/obo/GO_0035146 GO:0060114 biolink:BiologicalProcess vestibular receptor cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell. go.json vestibular hair cell differentiation http://purl.obolibrary.org/obo/GO_0060114 GO:0035147 biolink:BiologicalProcess branch fusion, open tracheal system Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint. go.json tracheal branch fusion http://purl.obolibrary.org/obo/GO_0035147 GO:2001310 biolink:BiologicalProcess gliotoxin biosynthetic process The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. go.json gliotoxin anabolism|gliotoxin biosynthesis|gliotoxin formation|gliotoxin synthesis http://purl.obolibrary.org/obo/GO_2001310 GO:0060115 biolink:BiologicalProcess vestibular receptor cell fate commitment The process in which a cell becomes committed to become a vestibular receptor cell. go.json vestibular hair cell fate commitment http://purl.obolibrary.org/obo/GO_0060115 GO:0035148 biolink:BiologicalProcess tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. go.json lumen formation in an anatomical structure|tube lumen formation http://purl.obolibrary.org/obo/GO_0035148 GO:0035149 biolink:BiologicalProcess lumen formation, open tracheal system Creation of the central hole of a tube in an open tracheal system through which gases flow. go.json tracheal lumen formation http://purl.obolibrary.org/obo/GO_0035149 GO:0060116 biolink:BiologicalProcess vestibular receptor cell morphogenesis Any process that alters the size or shape of a vestibular receptor cell. go.json vestibular hair cell morphogenesis http://purl.obolibrary.org/obo/GO_0060116 GO:2001311 biolink:BiologicalProcess lysobisphosphatidic acid metabolic process The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group. go.json LBPA metabolic process|LBPA metabolism|bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process|bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism|bis(monoacylglycerol) hydrogen phosphate metabolic process|bis(monoacylglycerol) hydrogen phosphate metabolism|lysobisphosphatidic acid metabolism http://purl.obolibrary.org/obo/GO_2001311 GO:2001312 biolink:BiologicalProcess lysobisphosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group. go.json LBPA anabolism|LBPA biosynthesis|LBPA biosynthetic process|LBPA formation|LBPA synthesis|bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism|bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis|bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process|bis(monoacylglycerol) hydrogen phosphate (BMP) formation|bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis|bis(monoacylglycerol) hydrogen phosphate anabolism|bis(monoacylglycerol) hydrogen phosphate biosynthesis|bis(monoacylglycerol) hydrogen phosphate biosynthetic process|bis(monoacylglycerol) hydrogen phosphate formation|bis(monoacylglycerol) hydrogen phosphate synthesis|lysobisphosphatidic acid anabolism|lysobisphosphatidic acid biosynthesis|lysobisphosphatidic acid formation|lysobisphosphatidic acid synthesis http://purl.obolibrary.org/obo/GO_2001312 GO:0060117 biolink:BiologicalProcess auditory receptor cell development The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json auditory hair cell development http://purl.obolibrary.org/obo/GO_0060117 GO:0098729 biolink:BiologicalProcess germline stem cell symmetric division Division of a germline stem cell to produce two germline stem cells of the same type as the parent. go.json http://purl.obolibrary.org/obo/GO_0098729 GO:2001313 biolink:BiologicalProcess UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. go.json UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolism http://purl.obolibrary.org/obo/GO_2001313 GO:0060118 biolink:BiologicalProcess vestibular receptor cell development The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json vestibular hair cell development http://purl.obolibrary.org/obo/GO_0060118 GO:0060119 biolink:BiologicalProcess inner ear receptor cell development The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json inner ear hair cell development http://purl.obolibrary.org/obo/GO_0060119 GO:0098727 biolink:BiologicalProcess maintenance of cell number Any process by which the numbers of cells of a particular type or in a tissue are maintained. go.json http://purl.obolibrary.org/obo/GO_0098727 GO:0098728 biolink:BiologicalProcess germline stem cell asymmetric division The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. go.json http://purl.obolibrary.org/obo/GO_0098728 GO:0098725 biolink:BiologicalProcess symmetric cell division Cell division in which both daughter cells are of the same type. go.json http://purl.obolibrary.org/obo/GO_0098725 GO:0098726 biolink:BiologicalProcess symmetric division of skeletal muscle satellite stem cell The symmetric division of a skeletal muscle satellite stem cell, resulting in two skeletal muscle satellite stem cells. This process is involved in amplification of the pool of these cells. go.json http://purl.obolibrary.org/obo/GO_0098726 GO:0035140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035140 GO:0098723 biolink:CellularComponent skeletal muscle myofibril A myofibril of a skeletal muscle fiber. go.json http://purl.obolibrary.org/obo/GO_0098723 GO:0050781 biolink:MolecularActivity ortho-trichlorophenol reductive dehalogenase activity Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl. go.json 2,4,6-TCP reductive dehalogenase activity|2,4,6-trichlorophenol reductive dehalogenase activity http://purl.obolibrary.org/obo/GO_0050781 GO:0035141 biolink:BiologicalProcess medial fin morphogenesis The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. go.json median fin morphogenesis|unpaired fin morphogenesis http://purl.obolibrary.org/obo/GO_0035141 GO:0050782 biolink:MolecularActivity galactose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in). go.json galactose, glucose uniporter activity http://purl.obolibrary.org/obo/GO_0050782 GO:0098724 biolink:BiologicalProcess symmetric stem cell division Symmetric division of a stem cell to produce two stem cells of the same type as the parent. Symmetric stem cell division is necessary for amplification of stem cell populations in the absence of sources of stem cells external to an existing population. go.json http://purl.obolibrary.org/obo/GO_0098724 GO:0098721 biolink:BiologicalProcess uracil import across plasma membrane The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol. go.json uracil import into cell http://purl.obolibrary.org/obo/GO_0098721 GO:0035142 biolink:BiologicalProcess dorsal fin morphogenesis The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. go.json http://purl.obolibrary.org/obo/GO_0035142 GO:0050780 biolink:MolecularActivity dopamine receptor binding Binding to a dopamine receptor. go.json http://purl.obolibrary.org/obo/GO_0050780 GO:0098722 biolink:BiologicalProcess asymmetric stem cell division Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. go.json http://purl.obolibrary.org/obo/GO_0098722 GO:0035143 biolink:BiologicalProcess caudal fin morphogenesis The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion. go.json http://purl.obolibrary.org/obo/GO_0035143 GO:0050796 biolink:BiologicalProcess regulation of insulin secretion Any process that modulates the frequency, rate or extent of the regulated release of insulin. go.json http://purl.obolibrary.org/obo/GO_0050796 GO:0098730 biolink:BiologicalProcess male germline stem cell symmetric division The symmetric division of a male germline stem cell to produce two male germline stem cells. An example of this is found in mammalian spermatogonial stem cells, some proportion of which divide symmetrically, so amplifying the population. The choice between asymmetric and symmetric division in this case appears to be internal and stochastic. go.json http://purl.obolibrary.org/obo/GO_0098730 GO:0050797 biolink:MolecularActivity thymidylate synthase (FAD) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+. EC:2.1.1.148|KEGG_REACTION:R06613|MetaCyc:RXN-8850|RHEA:29043 go.json 5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity|FDTS activity|Thy1 activity|ThyX activity|flavin dependent thymidylate synthase activity http://purl.obolibrary.org/obo/GO_0050797 GO:0098731 biolink:BiologicalProcess skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. go.json http://purl.obolibrary.org/obo/GO_0098731 GO:0050794 biolink:BiologicalProcess regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. go.json regulation of cellular physiological process http://purl.obolibrary.org/obo/GO_0050794 gocheck_do_not_annotate GO:0050795 biolink:BiologicalProcess regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. go.json regulation of behaviour http://purl.obolibrary.org/obo/GO_0050795 GO:1902308 biolink:BiologicalProcess regulation of peptidyl-serine dephosphorylation Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation. go.json http://purl.obolibrary.org/obo/GO_1902308 GO:1902309 biolink:BiologicalProcess negative regulation of peptidyl-serine dephosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation. go.json down regulation of peptidyl-serine dephosphorylation|down-regulation of peptidyl-serine dephosphorylation|downregulation of peptidyl-serine dephosphorylation|inhibition of peptidyl-serine dephosphorylation http://purl.obolibrary.org/obo/GO_1902309 GO:0050798 biolink:BiologicalProcess activated T cell proliferation The expansion of a T cell population following activation by an antigenic stimulus. go.json activated T lymphocyte proliferation|activated T-cell proliferation|activated T-lymphocyte proliferation|proliferation of activated T cells http://purl.obolibrary.org/obo/GO_0050798 GO:1902306 biolink:BiologicalProcess negative regulation of sodium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. go.json down regulation of sodium ion membrane transport|down regulation of sodium ion transmembrane transport|down-regulation of sodium ion membrane transport|down-regulation of sodium ion transmembrane transport|downregulation of sodium ion membrane transport|downregulation of sodium ion transmembrane transport|inhibition of sodium ion membrane transport|inhibition of sodium ion transmembrane transport|negative regulation of sodium ion membrane transport http://purl.obolibrary.org/obo/GO_1902306 GO:1902307 biolink:BiologicalProcess positive regulation of sodium ion transmembrane transport Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. go.json activation of sodium ion membrane transport|activation of sodium ion transmembrane transport|positive regulation of sodium ion membrane transport|up regulation of sodium ion membrane transport|up regulation of sodium ion transmembrane transport|up-regulation of sodium ion membrane transport|up-regulation of sodium ion transmembrane transport|upregulation of sodium ion membrane transport|upregulation of sodium ion transmembrane transport http://purl.obolibrary.org/obo/GO_1902307 GO:0050799 biolink:BiologicalProcess cocaine biosynthetic process The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. go.json cocaine anabolism|cocaine biosynthesis|cocaine formation|cocaine synthesis http://purl.obolibrary.org/obo/GO_0050799 GO:1902304 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902304 GO:1902305 biolink:BiologicalProcess regulation of sodium ion transmembrane transport Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. go.json regulation of sodium ion membrane transport http://purl.obolibrary.org/obo/GO_1902305 GO:1902302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902302 GO:1902303 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902303 GO:1902300 biolink:BiologicalProcess galactarate transmembrane transport The process in which galactaric acid anion (galactarate) is transported across a lipid bilayer, from one side of a membrane to the other. go.json D-galactarate transport|galactarate transport|galactaric acid anion transport http://purl.obolibrary.org/obo/GO_1902300 GO:1902301 biolink:MolecularActivity galactarate transmembrane transporter activity Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other. go.json D-galactarate transmembrane transporter activity|galactaric acid anion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1902301 GO:0060100 biolink:BiologicalProcess positive regulation of phagocytosis, engulfment Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0060100 GO:0035133 biolink:BiologicalProcess post-embryonic caudal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. go.json http://purl.obolibrary.org/obo/GO_0035133 GO:0060101 biolink:BiologicalProcess negative regulation of phagocytosis, engulfment Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0060101 GO:0035134 biolink:BiologicalProcess post-embryonic dorsal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. go.json http://purl.obolibrary.org/obo/GO_0035134 GO:0060102 biolink:CellularComponent collagen and cuticulin-based cuticle extracellular matrix A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans. go.json collagen and cuticulin-based exoskeleton extracellular matrix http://purl.obolibrary.org/obo/GO_0060102 GO:0035135 biolink:BiologicalProcess post-embryonic anal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. go.json http://purl.obolibrary.org/obo/GO_0035135 GO:0035136 biolink:BiologicalProcess forelimb morphogenesis The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. go.json arm morphogenesis http://purl.obolibrary.org/obo/GO_0035136 GO:0060103 biolink:CellularComponent obsolete collagen and cuticulin-based cuticle extracellular matrix part OBSOLETE. Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. go.json True http://purl.obolibrary.org/obo/GO_0060103 GO:0060104 biolink:CellularComponent surface coat of collagen and cuticulin-based cuticle extracellular matrix An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans. go.json surface coat of collagen and cuticulin-based exoskeleton extracellular matrix http://purl.obolibrary.org/obo/GO_0060104 GO:0035137 biolink:BiologicalProcess hindlimb morphogenesis The process in which the anatomical structures of the hindlimb are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0035137 GO:0060105 biolink:CellularComponent epicuticle of collagen and cuticulin-based cuticle extracellular matrix A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans. go.json epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix http://purl.obolibrary.org/obo/GO_0060105 GO:0035138 biolink:BiologicalProcess pectoral fin morphogenesis The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. go.json http://purl.obolibrary.org/obo/GO_0035138 GO:0060106 biolink:CellularComponent cortical layer of collagen and cuticulin-based cuticle extracellular matrix The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans. go.json http://purl.obolibrary.org/obo/GO_0060106 GO:0035139 biolink:BiologicalProcess pelvic fin morphogenesis The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. go.json http://purl.obolibrary.org/obo/GO_0035139 GO:0060107 biolink:CellularComponent annuli extracellular matrix The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present. go.json annulae|annular rings|annule(s)|annulus http://purl.obolibrary.org/obo/GO_0060107 GO:0060108 biolink:CellularComponent annular furrow extracellular matrix The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline. go.json http://purl.obolibrary.org/obo/GO_0060108 GO:0098738 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098738 GO:0060109 biolink:CellularComponent medial layer of collagen and cuticulin-based cuticle extracellular matrix The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals. go.json medial layer struts http://purl.obolibrary.org/obo/GO_0060109 GO:0098739 biolink:BiologicalProcess import across plasma membrane The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol. go.json uptake http://purl.obolibrary.org/obo/GO_0098739 GO:0098736 biolink:BiologicalProcess negative regulation of the force of heart contraction Any process that decreases the force of heart muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0098736 GO:0098737 biolink:BiologicalProcess protein insertion into plasma membrane The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. go.json http://purl.obolibrary.org/obo/GO_0098737 GO:0098734 biolink:BiologicalProcess macromolecule depalmitoylation The removal of palymitoyl groups from a macromolecule. go.json http://purl.obolibrary.org/obo/GO_0098734 GO:0050792 biolink:BiologicalProcess regulation of viral process Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. go.json regulation of viral reproduction http://purl.obolibrary.org/obo/GO_0050792 GO:0098735 biolink:BiologicalProcess positive regulation of the force of heart contraction Any process that increases the force of heart muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0098735 GO:0035130 biolink:BiologicalProcess post-embryonic pectoral fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. go.json http://purl.obolibrary.org/obo/GO_0035130 GO:0050793 biolink:BiologicalProcess regulation of developmental process Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). go.json http://purl.obolibrary.org/obo/GO_0050793 GO:0098732 biolink:BiologicalProcess macromolecule deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. go.json http://purl.obolibrary.org/obo/GO_0098732 GO:0050790 biolink:BiologicalProcess regulation of catalytic activity Any process that modulates the activity of an enzyme. go.json regulation of enzyme activity|regulation of metalloenzyme activity http://purl.obolibrary.org/obo/GO_0050790 gocheck_do_not_annotate|goslim_chembl GO:0035131 biolink:BiologicalProcess post-embryonic pelvic fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. go.json http://purl.obolibrary.org/obo/GO_0035131 GO:0098733 biolink:CellularComponent hemidesmosome associated protein complex Any protein complex that is part of or has some part in a hemidesmosome. go.json http://purl.obolibrary.org/obo/GO_0098733 GO:0035132 biolink:BiologicalProcess post-embryonic medial fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. go.json post-embryonic unpaired fin morphogenesis http://purl.obolibrary.org/obo/GO_0035132 GO:0050791 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050791 GO:1902319 biolink:BiologicalProcess DNA strand elongation involved in nuclear cell cycle DNA replication Any DNA strand elongation that is involved in nuclear cell cycle DNA replication. go.json DNA strand elongation involved in DNA replication during S phase|DNA strand elongation involved in DNA replication involved in S phase|DNA strand elongation involved in DNA replication involved in S-phase http://purl.obolibrary.org/obo/GO_1902319 GO:1902317 biolink:BiologicalProcess nuclear DNA replication termination Any DNA replication termination that is involved in nuclear cell cycle DNA replication. go.json DNA replication termination involved in DNA replication during S phase|DNA replication termination involved in DNA replication involved in S phase|DNA replication termination involved in DNA replication involved in S-phase|DNA replication termination involved in nuclear cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902317 GO:1902318 biolink:BiologicalProcess synthesis of RNA primer involved in nuclear cell cycle DNA replication Any synthesis of RNA primer that is involved in nuclear cell cycle DNA replication. go.json DNA replication, synthesis of RNA primer involved in DNA replication during S phase|DNA replication, synthesis of RNA primer involved in DNA replication involved in S phase|DNA replication, synthesis of RNA primer involved in DNA replication involved in S-phase|replication priming involved in DNA replication during S phase|replication priming involved in DNA replication involved in S phase|replication priming involved in DNA replication involved in S-phase|replication priming involved in nuclear cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902318 GO:1902315 biolink:BiologicalProcess nuclear cell cycle DNA replication initiation Any DNA replication initiation that is involved in nuclear cell cycle DNA replication. go.json DNA endoreduplication initiation involved in nuclear cell cycle DNA replication|DNA re-replication initiation involved in nuclear cell cycle DNA replication|DNA replication initiation involved in nuclear cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902315 GO:1902316 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902316 GO:1902313 biolink:BiologicalProcess positive regulation of copper ion transmembrane transport Any process that activates or increases the frequency, rate or extent of copper ion transmembrane transport. go.json activation of copper cation transmembrane transport|activation of copper ion membrane transport|activation of copper ion transmembrane transport|positive regulation of copper cation transmembrane transport|positive regulation of copper ion membrane transport|up regulation of copper cation transmembrane transport|up regulation of copper ion membrane transport|up regulation of copper ion transmembrane transport|up-regulation of copper cation transmembrane transport|up-regulation of copper ion membrane transport|up-regulation of copper ion transmembrane transport|upregulation of copper cation transmembrane transport|upregulation of copper ion membrane transport|upregulation of copper ion transmembrane transport http://purl.obolibrary.org/obo/GO_1902313 GO:1902314 biolink:MolecularActivity hydroquinone binding Binding to hydroquinone. go.json quinol binding http://purl.obolibrary.org/obo/GO_1902314 GO:1902311 biolink:BiologicalProcess regulation of copper ion transmembrane transport Any process that modulates the frequency, rate or extent of copper ion transmembrane transport. go.json regulation of copper cation transmembrane transport|regulation of copper ion membrane transport http://purl.obolibrary.org/obo/GO_1902311 GO:1902312 biolink:BiologicalProcess negative regulation of copper ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of copper ion transmembrane transport. go.json down regulation of copper cation transmembrane transport|down regulation of copper ion membrane transport|down regulation of copper ion transmembrane transport|down-regulation of copper cation transmembrane transport|down-regulation of copper ion membrane transport|down-regulation of copper ion transmembrane transport|downregulation of copper cation transmembrane transport|downregulation of copper ion membrane transport|downregulation of copper ion transmembrane transport|inhibition of copper cation transmembrane transport|inhibition of copper ion membrane transport|inhibition of copper ion transmembrane transport|negative regulation of copper cation transmembrane transport|negative regulation of copper ion membrane transport http://purl.obolibrary.org/obo/GO_1902312 GO:0060130 biolink:BiologicalProcess thyroid-stimulating hormone-secreting cell development The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. go.json TSH-secreting cell development|beta-basophil development|thyroid stimulating hormone secreting cell development|thyrotrope development|thyrotroph development http://purl.obolibrary.org/obo/GO_0060130 GO:0060131 biolink:BiologicalProcess corticotropin hormone secreting cell development The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin. go.json adrenocorticotrophic hormone secreting cell development|adrenocorticotropic hormone secreting cell development|corticotrope development|corticotroph development|corticotrophin hormone secreting cell development http://purl.obolibrary.org/obo/GO_0060131 GO:1902310 biolink:BiologicalProcess positive regulation of peptidyl-serine dephosphorylation Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation. go.json activation of peptidyl-serine dephosphorylation|up regulation of peptidyl-serine dephosphorylation|up-regulation of peptidyl-serine dephosphorylation|upregulation of peptidyl-serine dephosphorylation http://purl.obolibrary.org/obo/GO_1902310 GO:0060132 biolink:BiologicalProcess prolactin secreting cell development The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin. go.json epsilon-acidophil development|lactotrope development|lactotroph development|lactotropic cell development|mammotrope development|mammotroph development|mammotrophic cell development|mammotropic cell development http://purl.obolibrary.org/obo/GO_0060132 GO:0060133 biolink:BiologicalProcess somatotropin secreting cell development The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. go.json growth hormone secreting cell development|somatotrope development|somatotroph development|somatotrophin secreting cell development|somatotropic cell development|somatrophic cell development http://purl.obolibrary.org/obo/GO_0060133 GO:0035122 biolink:BiologicalProcess embryonic medial fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. go.json embryonic unpaired fin morphogenesis http://purl.obolibrary.org/obo/GO_0035122 GO:0035123 biolink:BiologicalProcess embryonic dorsal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. go.json http://purl.obolibrary.org/obo/GO_0035123 GO:0060134 biolink:BiologicalProcess prepulse inhibition The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. Wikipedia:Prepulse_inhibition go.json PPI|pre-pulse inhibition http://purl.obolibrary.org/obo/GO_0060134 GO:0060135 biolink:BiologicalProcess maternal process involved in female pregnancy A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. go.json http://purl.obolibrary.org/obo/GO_0060135 GO:0035124 biolink:BiologicalProcess embryonic caudal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. go.json http://purl.obolibrary.org/obo/GO_0035124 GO:0035125 biolink:BiologicalProcess embryonic anal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. go.json http://purl.obolibrary.org/obo/GO_0035125 GO:0060136 biolink:BiologicalProcess embryonic process involved in female pregnancy A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. go.json http://purl.obolibrary.org/obo/GO_0060136 GO:0098709 biolink:BiologicalProcess glutathione import across plasma membrane The directed movement of glutathione from outside of a cell, across the plasma membrane and into the cytosol. go.json glutathione import into cell|glutathione uptake http://purl.obolibrary.org/obo/GO_0098709 GO:0035126 biolink:BiologicalProcess post-embryonic genitalia morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized. go.json post-embryonic genital morphogenesis http://purl.obolibrary.org/obo/GO_0035126 GO:0060137 biolink:BiologicalProcess maternal process involved in parturition A reproductive process occurring in the mother that results in birth. go.json http://purl.obolibrary.org/obo/GO_0060137 GO:0060138 biolink:BiologicalProcess fetal process involved in parturition A reproductive process occurring in the embryo that results in birth. go.json http://purl.obolibrary.org/obo/GO_0060138 GO:0035127 biolink:BiologicalProcess post-embryonic limb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. go.json http://purl.obolibrary.org/obo/GO_0035127 GO:0035128 biolink:BiologicalProcess post-embryonic forelimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism. go.json http://purl.obolibrary.org/obo/GO_0035128 GO:0098707 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098707 GO:0060139 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060139 GO:0098708 biolink:BiologicalProcess glucose import across plasma membrane The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol. go.json glucose import into cell|high affinity glucose import http://purl.obolibrary.org/obo/GO_0098708 GO:0035129 biolink:BiologicalProcess post-embryonic hindlimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0035129 GO:0098705 biolink:BiologicalProcess copper ion import across plasma membrane The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol. go.json copper cation import into cell|copper ion import into cell|high affinity copper ion transport|high affinity copper transport|high-affinity copper ion transport http://purl.obolibrary.org/obo/GO_0098705 GO:0098706 biolink:BiologicalProcess iron ion import across cell outer membrane The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space. go.json ferric ion import into cell|ferric iron import across cell outer membrane|ferric iron import into cell|ferric iron transmembrane transport|high affinity ferric iron transport|high-affinity ferric iron transmembrane transport http://purl.obolibrary.org/obo/GO_0098706 GO:0098703 biolink:BiologicalProcess calcium ion import across plasma membrane The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. go.json calcium ion import into cell|calcium ion uptake into cell http://purl.obolibrary.org/obo/GO_0098703 GO:0098704 biolink:BiologicalProcess carbohydrate import across plasma membrane The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol. go.json carbohydrate import into cell http://purl.obolibrary.org/obo/GO_0098704 GO:0098701 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098701 GO:0098702 biolink:BiologicalProcess adenine import across plasma membrane The directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol. go.json adenine import into cell http://purl.obolibrary.org/obo/GO_0098702 GO:0035120 biolink:BiologicalProcess post-embryonic appendage morphogenesis The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. go.json http://purl.obolibrary.org/obo/GO_0035120 GO:0035121 biolink:BiologicalProcess obsolete tail morphogenesis OBSOLETE. The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals. go.json tail morphogenesis True http://purl.obolibrary.org/obo/GO_0035121 GO:0098700 biolink:BiologicalProcess neurotransmitter loading into synaptic vesicle The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps. go.json neurotransmitter import into synaptic vesicle|neurotransmitter uptake into synaptic vesicle|synaptic vesicle neurotransmitter loading http://purl.obolibrary.org/obo/GO_0098700 goslim_synapse GO:1902328 biolink:BiologicalProcess bacterial-type DNA replication initiation Any DNA replication initiation that is involved in bacterial-type DNA replication. go.json DNA endoreduplication initiation involved in bacterial-type DNA replication|DNA re-replication initiation involved in bacterial-type DNA replication|DNA replication initiation involved in bacterial-type DNA replication|DNA-dependent DNA replication initiation involved in bacterial-type DNA replication http://purl.obolibrary.org/obo/GO_1902328 GO:1902329 biolink:BiologicalProcess bacterial-type DNA replication termination Any DNA replication termination that is involved in bacterial-type DNA replication. go.json DNA replication termination involved in bacterial-type DNA replication http://purl.obolibrary.org/obo/GO_1902329 GO:0035119 biolink:BiologicalProcess embryonic pelvic fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. go.json http://purl.obolibrary.org/obo/GO_0035119 GO:1902326 biolink:BiologicalProcess positive regulation of chlorophyll biosynthetic process Any process that activates or increases the frequency, rate or extent of chlorophyll biosynthetic process. go.json activation of chlorophyll anabolism|activation of chlorophyll biosynthesis|activation of chlorophyll biosynthetic process|activation of chlorophyll formation|activation of chlorophyll synthesis|positive regulation of chlorophyll anabolism|positive regulation of chlorophyll biosynthesis|positive regulation of chlorophyll formation|positive regulation of chlorophyll synthesis|up regulation of chlorophyll anabolism|up regulation of chlorophyll biosynthesis|up regulation of chlorophyll biosynthetic process|up regulation of chlorophyll formation|up regulation of chlorophyll synthesis|up-regulation of chlorophyll anabolism|up-regulation of chlorophyll biosynthesis|up-regulation of chlorophyll biosynthetic process|up-regulation of chlorophyll formation|up-regulation of chlorophyll synthesis|upregulation of chlorophyll anabolism|upregulation of chlorophyll biosynthesis|upregulation of chlorophyll biosynthetic process|upregulation of chlorophyll formation|upregulation of chlorophyll synthesis http://purl.obolibrary.org/obo/GO_1902326 GO:1902327 biolink:BiologicalProcess bacterial-type DNA replication DNA ligation Any DNA ligation that is involved in bacterial-type DNA replication. go.json DNA ligation involved in bacterial-type DNA replication http://purl.obolibrary.org/obo/GO_1902327 GO:1902324 biolink:BiologicalProcess positive regulation of methyl-branched fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process. go.json activation of methyl-branched fatty acid anabolism|activation of methyl-branched fatty acid biosynthesis|activation of methyl-branched fatty acid biosynthetic process|activation of methyl-branched fatty acid formation|activation of methyl-branched fatty acid synthesis|positive regulation of methyl-branched fatty acid anabolism|positive regulation of methyl-branched fatty acid biosynthesis|positive regulation of methyl-branched fatty acid formation|positive regulation of methyl-branched fatty acid synthesis|up regulation of methyl-branched fatty acid anabolism|up regulation of methyl-branched fatty acid biosynthesis|up regulation of methyl-branched fatty acid biosynthetic process|up regulation of methyl-branched fatty acid formation|up regulation of methyl-branched fatty acid synthesis|up-regulation of methyl-branched fatty acid anabolism|up-regulation of methyl-branched fatty acid biosynthesis|up-regulation of methyl-branched fatty acid biosynthetic process|up-regulation of methyl-branched fatty acid formation|up-regulation of methyl-branched fatty acid synthesis|upregulation of methyl-branched fatty acid anabolism|upregulation of methyl-branched fatty acid biosynthesis|upregulation of methyl-branched fatty acid biosynthetic process|upregulation of methyl-branched fatty acid formation|upregulation of methyl-branched fatty acid synthesis http://purl.obolibrary.org/obo/GO_1902324 GO:1902325 biolink:BiologicalProcess negative regulation of chlorophyll biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll biosynthetic process. go.json down regulation of chlorophyll anabolism|down regulation of chlorophyll biosynthesis|down regulation of chlorophyll biosynthetic process|down regulation of chlorophyll formation|down regulation of chlorophyll synthesis|down-regulation of chlorophyll anabolism|down-regulation of chlorophyll biosynthesis|down-regulation of chlorophyll biosynthetic process|down-regulation of chlorophyll formation|down-regulation of chlorophyll synthesis|downregulation of chlorophyll anabolism|downregulation of chlorophyll biosynthesis|downregulation of chlorophyll biosynthetic process|downregulation of chlorophyll formation|downregulation of chlorophyll synthesis|inhibition of chlorophyll anabolism|inhibition of chlorophyll biosynthesis|inhibition of chlorophyll biosynthetic process|inhibition of chlorophyll formation|inhibition of chlorophyll synthesis|negative regulation of chlorophyll anabolism|negative regulation of chlorophyll biosynthesis|negative regulation of chlorophyll formation|negative regulation of chlorophyll synthesis http://purl.obolibrary.org/obo/GO_1902325 GO:1902322 biolink:BiologicalProcess regulation of methyl-branched fatty acid biosynthetic process Any process that modulates the frequency, rate or extent of methyl-branched fatty acid biosynthetic process. go.json regulation of methyl-branched fatty acid anabolism|regulation of methyl-branched fatty acid biosynthesis|regulation of methyl-branched fatty acid formation|regulation of methyl-branched fatty acid synthesis http://purl.obolibrary.org/obo/GO_1902322 GO:1902323 biolink:BiologicalProcess negative regulation of methyl-branched fatty acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process. go.json down regulation of methyl-branched fatty acid anabolism|down regulation of methyl-branched fatty acid biosynthesis|down regulation of methyl-branched fatty acid biosynthetic process|down regulation of methyl-branched fatty acid formation|down regulation of methyl-branched fatty acid synthesis|down-regulation of methyl-branched fatty acid anabolism|down-regulation of methyl-branched fatty acid biosynthesis|down-regulation of methyl-branched fatty acid biosynthetic process|down-regulation of methyl-branched fatty acid formation|down-regulation of methyl-branched fatty acid synthesis|downregulation of methyl-branched fatty acid anabolism|downregulation of methyl-branched fatty acid biosynthesis|downregulation of methyl-branched fatty acid biosynthetic process|downregulation of methyl-branched fatty acid formation|downregulation of methyl-branched fatty acid synthesis|inhibition of methyl-branched fatty acid anabolism|inhibition of methyl-branched fatty acid biosynthesis|inhibition of methyl-branched fatty acid biosynthetic process|inhibition of methyl-branched fatty acid formation|inhibition of methyl-branched fatty acid synthesis|negative regulation of methyl-branched fatty acid anabolism|negative regulation of methyl-branched fatty acid biosynthesis|negative regulation of methyl-branched fatty acid formation|negative regulation of methyl-branched fatty acid synthesis http://purl.obolibrary.org/obo/GO_1902323 GO:1902320 biolink:BiologicalProcess nuclear DNA replication DNA duplex unwinding Any DNA duplex unwinding that is involved in nuclear cell cycle DNA replication. go.json DNA duplex unwinding involved in DNA replication during S phase|DNA duplex unwinding involved in DNA replication involved in S phase|DNA duplex unwinding involved in DNA replication involved in S-phase|DNA duplex unwinding involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication during S phase|DNA unwinding involved in DNA replication involved in S phase|DNA unwinding involved in DNA replication involved in S-phase|DNA unwinding involved in nuclear cell cycle DNA replication|duplex DNA melting involved in DNA replication during S phase|duplex DNA melting involved in DNA replication involved in S phase|duplex DNA melting involved in DNA replication involved in S-phase http://purl.obolibrary.org/obo/GO_1902320 GO:0060120 biolink:BiologicalProcess inner ear receptor cell fate commitment The process in which a cell becomes committed to become an inner ear receptor cell. go.json inner ear hair cell fate commitment http://purl.obolibrary.org/obo/GO_0060120 GO:1902321 biolink:BiologicalProcess methyl-branched fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of methyl-branched fatty acid. go.json methyl-branched fatty acid anabolism|methyl-branched fatty acid biosynthesis|methyl-branched fatty acid formation|methyl-branched fatty acid synthesis http://purl.obolibrary.org/obo/GO_1902321 GO:0060121 biolink:BiologicalProcess vestibular receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells. go.json vestibular hair cell stereocilium organization|vestibular receptor cell stereocilium organisation|vestibular receptor cell stereocilium organization and biogenesis http://purl.obolibrary.org/obo/GO_0060121 GO:0035111 biolink:BiologicalProcess obsolete leg joint morphogenesis OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur. go.json leg joint morphogenesis True http://purl.obolibrary.org/obo/GO_0035111 GO:0060122 biolink:BiologicalProcess inner ear receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. go.json inner ear hair cell receptor stereocilium organization|inner ear receptor stereocilium organisation|inner ear receptor stereocilium organization and biogenesis http://purl.obolibrary.org/obo/GO_0060122 GO:0035112 biolink:BiologicalProcess genitalia morphogenesis The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. go.json genital morphogenesis http://purl.obolibrary.org/obo/GO_0035112 GO:1902330 biolink:BiologicalProcess synthesis of RNA primer involved in bacterial-type DNA replication Any synthesis of RNA primer that is involved in bacterial-type DNA replication. go.json replication priming involved in bacterial-type DNA replication http://purl.obolibrary.org/obo/GO_1902330 GO:0060123 biolink:BiologicalProcess regulation of growth hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. go.json http://purl.obolibrary.org/obo/GO_0060123 GO:0060124 biolink:BiologicalProcess positive regulation of growth hormone secretion Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell. go.json http://purl.obolibrary.org/obo/GO_0060124 GO:0035113 biolink:BiologicalProcess embryonic appendage morphogenesis The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. go.json http://purl.obolibrary.org/obo/GO_0035113 GO:0060125 biolink:BiologicalProcess negative regulation of growth hormone secretion Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell. go.json http://purl.obolibrary.org/obo/GO_0060125 GO:0035114 biolink:BiologicalProcess imaginal disc-derived appendage morphogenesis The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism. go.json http://purl.obolibrary.org/obo/GO_0035114 GO:0060126 biolink:BiologicalProcess somatotropin secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. go.json growth hormone secreting cell differentiation|somatotrope differentiation|somatotroph differentiation|somatotrophin secreting cell differentiation|somatotropic cell differentiation|somatrophic cell differentiation http://purl.obolibrary.org/obo/GO_0060126 GO:0035115 biolink:BiologicalProcess embryonic forelimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. go.json embryonic arm morphogenesis http://purl.obolibrary.org/obo/GO_0035115 GO:0035116 biolink:BiologicalProcess embryonic hindlimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. go.json http://purl.obolibrary.org/obo/GO_0035116 GO:0060127 biolink:BiologicalProcess prolactin secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin. go.json epsilon-acidophil differentiation|lactotrope differentiation|lactotroph differentiation|lactotropic cell differentiation|mammotrope differentiation|mammotroph differentiation|mammotrophic cell differentiation|mammotropic cell differentiation http://purl.obolibrary.org/obo/GO_0060127 GO:0060128 biolink:BiologicalProcess corticotropin hormone secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin. go.json adrenocorticotrophic hormone secreting cell differentiation|adrenocorticotropic hormone secreting cell differentiation|corticotrope differentiation|corticotroph differentiation|corticotrophin hormone secreting cell differentiation http://purl.obolibrary.org/obo/GO_0060128 GO:0098718 biolink:BiologicalProcess serine import across plasma membrane The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol. go.json serine import into cell http://purl.obolibrary.org/obo/GO_0098718 GO:0035117 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035117 GO:0098719 biolink:BiologicalProcess sodium ion import across plasma membrane The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. go.json sodium import|sodium ion import|sodium ion import into cell http://purl.obolibrary.org/obo/GO_0098719 GO:0060129 biolink:BiologicalProcess thyroid-stimulating hormone-secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin. go.json TSH-secreting cell differentiation|beta-basophil differentiation|thyroid stimulating hormone secreting cell differentiation|thyrotrope differentiation|thyrotroph differentiation http://purl.obolibrary.org/obo/GO_0060129 GO:0035118 biolink:BiologicalProcess embryonic pectoral fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. go.json http://purl.obolibrary.org/obo/GO_0035118 GO:0098716 biolink:BiologicalProcess nickel cation import across plasma membrane The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol. go.json nickel cation import into cell http://purl.obolibrary.org/obo/GO_0098716 GO:0098717 biolink:BiologicalProcess pantothenate import across plasma membrane The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol. go.json pantothenate import|pantothenate import into cell http://purl.obolibrary.org/obo/GO_0098717 GO:0098714 biolink:BiologicalProcess malate import across plasma membrane The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol. go.json malate import into cell http://purl.obolibrary.org/obo/GO_0098714 GO:0098715 biolink:BiologicalProcess malonic acid import across plasma membrane The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol. go.json malonate import into cell|malonic acid import into cell http://purl.obolibrary.org/obo/GO_0098715 GO:0098712 biolink:BiologicalProcess L-glutamate import across plasma membrane The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. go.json L-glutamate import into cell|L-glutamate(1-) import across plasma membrane|L-glutamate(1-) import into cell http://purl.obolibrary.org/obo/GO_0098712 GO:0098713 biolink:BiologicalProcess leucine import across plasma membrane The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-leucine import into cell|leucine import into cell http://purl.obolibrary.org/obo/GO_0098713 GO:0098710 biolink:BiologicalProcess guanine import across plasma membrane The directed movement of guanine from outside of a cell, across the plasma membrane and into the cytosol. go.json guanine import into cell http://purl.obolibrary.org/obo/GO_0098710 GO:0098711 biolink:BiologicalProcess iron ion import across plasma membrane The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol. go.json ferrous ion import into cell|ferrous iron import across plasma membrane|ferrous iron import into cell|iron import into cell|iron ion import into cell http://purl.obolibrary.org/obo/GO_0098711 GO:0035110 biolink:BiologicalProcess obsolete leg morphogenesis OBSOLETE. The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands. go.json leg morphogenesis True http://purl.obolibrary.org/obo/GO_0035110 GO:0098763 biolink:BiologicalProcess mitotic cell cycle phase One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. go.json http://purl.obolibrary.org/obo/GO_0098763 gocheck_do_not_annotate GO:0098764 biolink:BiologicalProcess meiosis I cell cycle phase A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs. go.json http://purl.obolibrary.org/obo/GO_0098764 gocheck_do_not_annotate GO:0098761 biolink:BiologicalProcess cellular response to interleukin-7 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. go.json cellular response to IL-7 http://purl.obolibrary.org/obo/GO_0098761 GO:0098762 biolink:BiologicalProcess meiotic cell cycle phase One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. go.json http://purl.obolibrary.org/obo/GO_0098762 gocheck_do_not_annotate GO:0098760 biolink:BiologicalProcess response to interleukin-7 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. go.json response to IL-7 http://purl.obolibrary.org/obo/GO_0098760 GO:1902339 biolink:BiologicalProcess positive regulation of apoptotic process involved in morphogenesis Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. go.json activation of apoptosis involved in development|activation of apoptosis involved in morphogenesis|activation of apoptotic process involved in morphogenesis|activation of morphogenetic apoptosis|positive regulation of apoptosis involved in development|positive regulation of apoptosis involved in morphogenesis|positive regulation of morphogenetic apoptosis|up regulation of apoptosis involved in development|up regulation of apoptosis involved in morphogenesis|up regulation of apoptotic process involved in morphogenesis|up regulation of morphogenetic apoptosis|up-regulation of apoptosis involved in development|up-regulation of apoptosis involved in morphogenesis|up-regulation of apoptotic process involved in morphogenesis|up-regulation of morphogenetic apoptosis|upregulation of apoptosis involved in development|upregulation of apoptosis involved in morphogenesis|upregulation of apoptotic process involved in morphogenesis|upregulation of morphogenetic apoptosis http://purl.obolibrary.org/obo/GO_1902339 GO:1902337 biolink:BiologicalProcess regulation of apoptotic process involved in morphogenesis Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. go.json regulation of apoptosis involved in development|regulation of apoptosis involved in morphogenesis|regulation of morphogenetic apoptosis http://purl.obolibrary.org/obo/GO_1902337 GO:0035108 biolink:BiologicalProcess limb morphogenesis The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. go.json limb bud morphogenesis http://purl.obolibrary.org/obo/GO_0035108 GO:1902338 biolink:BiologicalProcess negative regulation of apoptotic process involved in morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. go.json down regulation of apoptosis involved in development|down regulation of apoptosis involved in morphogenesis|down regulation of apoptotic process involved in morphogenesis|down regulation of morphogenetic apoptosis|down-regulation of apoptosis involved in development|down-regulation of apoptosis involved in morphogenesis|down-regulation of apoptotic process involved in morphogenesis|down-regulation of morphogenetic apoptosis|downregulation of apoptosis involved in development|downregulation of apoptosis involved in morphogenesis|downregulation of apoptotic process involved in morphogenesis|downregulation of morphogenetic apoptosis|inhibition of apoptosis involved in development|inhibition of apoptosis involved in morphogenesis|inhibition of apoptotic process involved in morphogenesis|inhibition of morphogenetic apoptosis|negative regulation of apoptosis involved in development|negative regulation of apoptosis involved in morphogenesis|negative regulation of morphogenetic apoptosis http://purl.obolibrary.org/obo/GO_1902338 GO:0035109 biolink:BiologicalProcess obsolete imaginal disc-derived limb morphogenesis OBSOLETE. The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster. go.json imaginal disc-derived limb morphogenesis True http://purl.obolibrary.org/obo/GO_0035109 GO:1902335 biolink:BiologicalProcess obsolete positive chemotaxis involved in neuron migration OBSOLETE. Any positive chemotaxis that is involved in neuron migration. go.json chemoattraction involved in neuron chemotaxis|chemoattraction involved in neuron guidance|chemoattraction involved in neuron migration|chemoattraction involved in neuronal migration|positive chemotaxis involved in neuron chemotaxis|positive chemotaxis involved in neuron guidance|positive chemotaxis involved in neuron migration|positive chemotaxis involved in neuronal migration True http://purl.obolibrary.org/obo/GO_1902335 GO:1902336 biolink:BiologicalProcess positive regulation of retinal ganglion cell axon guidance Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance. go.json activation of retinal ganglion cell axon guidance|activation of retinal ganglion cell axon pathfinding|positive regulation of retinal ganglion cell axon pathfinding|up regulation of retinal ganglion cell axon guidance|up regulation of retinal ganglion cell axon pathfinding|up-regulation of retinal ganglion cell axon guidance|up-regulation of retinal ganglion cell axon pathfinding|upregulation of retinal ganglion cell axon guidance|upregulation of retinal ganglion cell axon pathfinding http://purl.obolibrary.org/obo/GO_1902336 GO:0060150 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060150 GO:0060151 biolink:BiologicalProcess peroxisome localization Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. go.json peroxisome localisation http://purl.obolibrary.org/obo/GO_0060151 GO:1902333 biolink:BiologicalProcess nuclear DNA replication DNA ligation Any DNA ligation that is involved in nuclear cell cycle DNA replication. go.json DNA ligation involved in DNA replication during S phase|DNA ligation involved in DNA replication involved in S phase|DNA ligation involved in DNA replication involved in S-phase|DNA ligation involved in nuclear cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902333 GO:1902334 biolink:BiologicalProcess fructose export from vacuole to cytoplasm The directed movement of fructose from vacuole to cytoplasm. go.json fructose transport from vacuole to cytoplasm http://purl.obolibrary.org/obo/GO_1902334 GO:0060152 biolink:BiologicalProcess microtubule-based peroxisome localization The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. go.json microtubule-based peroxisome localisation http://purl.obolibrary.org/obo/GO_0060152 GO:0060153 biolink:BiologicalProcess perturbation by virus of host cell cycle progression A process in which a virus interferes with the normal progression through the host cell cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction. VZ:1636 go.json modulation by virus of host cell cycle|modulation of host cell cycle by virus|regulation by virus of host cell cycle|regulation of host cell cycle by virus|viral process regulating host cell cycle http://purl.obolibrary.org/obo/GO_0060153 GO:1902331 biolink:BiologicalProcess obsolete DNA strand elongation involved in bacterial-type DNA replication OBSOLETE. Any DNA strand elongation that is involved in bacterial-type DNA replication. go.json True http://purl.obolibrary.org/obo/GO_1902331 GO:1902332 biolink:BiologicalProcess bacterial-type DNA replication DNA duplex unwinding Any DNA duplex unwinding that is involved in bacterial-type DNA replication. go.json DNA duplex unwinding involved in bacterial-type DNA replication|DNA unwinding involved in bacterial-type DNA replication|duplex DNA melting involved in bacterial-type DNA replication http://purl.obolibrary.org/obo/GO_1902332 GO:0060154 biolink:BiologicalProcess obsolete cellular process regulating host cell cycle in response to virus OBSOLETE. Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus. go.json True http://purl.obolibrary.org/obo/GO_0060154 GO:1902340 biolink:BiologicalProcess negative regulation of chromosome condensation Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. go.json down regulation of chromosome condensation|down regulation of eukaryotic chromosome condensation|down regulation of nuclear chromosome condensation|down-regulation of chromosome condensation|down-regulation of eukaryotic chromosome condensation|down-regulation of nuclear chromosome condensation|downregulation of chromosome condensation|downregulation of eukaryotic chromosome condensation|downregulation of nuclear chromosome condensation|inhibition of chromosome condensation|inhibition of eukaryotic chromosome condensation|inhibition of nuclear chromosome condensation|negative regulation of eukaryotic chromosome condensation|negative regulation of nuclear chromosome condensation http://purl.obolibrary.org/obo/GO_1902340 GO:0035100 biolink:MolecularActivity ecdysone binding Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting. go.json http://purl.obolibrary.org/obo/GO_0035100 GO:0060155 biolink:BiologicalProcess platelet dense granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. go.json bull's eye body organization and biogenesis|platelet dense body organization and biogenesis|platelet dense granule organisation|platelet dense granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0060155 GO:0035101 biolink:CellularComponent FACT complex A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage. go.json Facilitates chromatin transcription complex http://purl.obolibrary.org/obo/GO_0035101 GO:1902341 biolink:BiologicalProcess xylitol transmembrane transport The directed movement of a xylitol across a membrane. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose. go.json xylitol transport http://purl.obolibrary.org/obo/GO_1902341 GO:0060156 biolink:BiologicalProcess milk ejection reflex A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness. go.json milk ejection http://purl.obolibrary.org/obo/GO_0060156 GO:0060157 biolink:BiologicalProcess urinary bladder development The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion. go.json http://purl.obolibrary.org/obo/GO_0060157 GO:0035102 biolink:CellularComponent PRC1 complex A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. go.json Polycomb repressive complex 1 http://purl.obolibrary.org/obo/GO_0035102 GO:0060158 biolink:BiologicalProcess phospholipase C-activating dopamine receptor signaling pathway A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signalling pathway|dopamine receptor, phospholipase C activating pathway http://purl.obolibrary.org/obo/GO_0060158 GO:0035103 biolink:BiologicalProcess obsolete sterol regulatory element binding protein cleavage OBSOLETE. The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids. go.json SREBP cleavage|sterol depletion response, SREBP cleavage|sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway True http://purl.obolibrary.org/obo/GO_0035103 GO:0035104 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035104 GO:0060159 biolink:BiologicalProcess regulation of dopamine receptor signaling pathway Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. go.json regulation of dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060159 GO:0035105 biolink:BiologicalProcess obsolete sterol regulatory element binding protein import into nucleus OBSOLETE. The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. go.json SREBP import into nucleus|SREBP import into nucleus involved in sterol depletion response|SREBP nuclear translocation|sterol depletion response, SREBP import into nucleus|sterol depletion response, SREBP nuclear translocation|sterol depletion response, sterol regulatory element binding protein import into nucleus|sterol depletion response, sterol regulatory element binding protein nuclear translocation|sterol regulatory element binding protein import into nucleus involved in sterol depletion response|sterol regulatory element binding protein nuclear translocation|sterol regulatory element binding protein nuclear translocation involved in sterol depletion response True http://purl.obolibrary.org/obo/GO_0035105 GO:0035106 biolink:BiologicalProcess operant conditioning Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior. Wikipedia:Operant_conditioning go.json instrumental conditioning http://purl.obolibrary.org/obo/GO_0035106 GO:0035107 biolink:BiologicalProcess appendage morphogenesis The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. go.json http://purl.obolibrary.org/obo/GO_0035107 GO:0098769 biolink:MolecularActivity TIMP family protein binding Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family. go.json http://purl.obolibrary.org/obo/GO_0098769 GO:0098767 biolink:BiologicalProcess obsolete meiosis II M phase OBSOLETE. M phase during meiosis II. go.json True http://purl.obolibrary.org/obo/GO_0098767 GO:0098768 biolink:BiologicalProcess meiotic prometaphase I The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate. go.json http://purl.obolibrary.org/obo/GO_0098768 gocheck_do_not_annotate GO:0098765 biolink:BiologicalProcess meiosis II cell cycle phase A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division). go.json http://purl.obolibrary.org/obo/GO_0098765 gocheck_do_not_annotate GO:0098766 biolink:BiologicalProcess obsolete meiosis I M phase OBSOLETE. M phase during meiosis I. go.json True http://purl.obolibrary.org/obo/GO_0098766 GO:0098774 biolink:CellularComponent curli A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization. go.json tafi|thin aggregative fimbrae http://purl.obolibrary.org/obo/GO_0098774 GO:0098775 biolink:BiologicalProcess curli assembly The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex. go.json http://purl.obolibrary.org/obo/GO_0098775 GO:0098772 biolink:MolecularActivity molecular function regulator activity A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition. go.json molecular function regulator http://purl.obolibrary.org/obo/GO_0098772 gocheck_do_not_annotate|goslim_flybase_ribbon|goslim_generic|prokaryote_subset GO:0098773 biolink:BiologicalProcess skin epidermis development The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0098773 GO:0098770 biolink:MolecularActivity FBXO family protein binding Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction. go.json http://purl.obolibrary.org/obo/GO_0098770 GO:0098771 biolink:BiologicalProcess inorganic ion homeostasis Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0098771 goslim_pombe GO:1902348 biolink:BiologicalProcess cellular response to strigolactone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus. go.json cellular response to strigolactone analog GR24 http://purl.obolibrary.org/obo/GO_1902348 GO:1902349 biolink:BiologicalProcess response to chloroquine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus. go.json http://purl.obolibrary.org/obo/GO_1902349 GO:1902346 biolink:BiologicalProcess meiotic strand displacement involved in double-strand break repair via SDSA Any meiotic strand displacement that is involved in double-strand break repair via synthesis-dependent strand annealing (SDSA). go.json meiotic D-loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing|meiotic D-loop dissociation involved in mitotic gene conversion|meiotic D-loop processing involved in double-strand break repair via synthesis-dependent strand annealing|meiotic D-loop processing involved in mitotic gene conversion|meiotic displacement loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing|meiotic displacement loop dissociation involved in mitotic gene conversion|meiotic displacement loop processing involved in double-strand break repair via synthesis-dependent strand annealing|meiotic displacement loop processing involved in mitotic gene conversion|meiotic strand displacement involved in SDSA|meiotic strand displacement involved in double-strand break repair via synthesis-dependent strand annealing|meiotic strand displacement involved in mitotic gene conversion http://purl.obolibrary.org/obo/GO_1902346 GO:1902347 biolink:BiologicalProcess response to strigolactone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus. go.json response to strigolactone analog GR24 http://purl.obolibrary.org/obo/GO_1902347 GO:1902344 biolink:BiologicalProcess negative regulation of maltose transport Any process that stops, prevents or reduces the frequency, rate or extent of maltose transport. go.json down regulation of maltose transport|down-regulation of maltose transport|downregulation of maltose transport|inhibition of maltose transport http://purl.obolibrary.org/obo/GO_1902344 GO:0060140 biolink:BiologicalProcess modulation by virus of syncytium formation via plasma membrane fusion The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. go.json http://purl.obolibrary.org/obo/GO_0060140 GO:1902345 biolink:BiologicalProcess positive regulation of maltose transport Any process that activates or increases the frequency, rate or extent of maltose transport. go.json activation of maltose transport|up regulation of maltose transport|up-regulation of maltose transport|upregulation of maltose transport http://purl.obolibrary.org/obo/GO_1902345 GO:0060141 biolink:BiologicalProcess positive regulation of syncytium formation by virus The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. go.json syncytium formation induced by viral infection http://purl.obolibrary.org/obo/GO_0060141 GO:1902342 biolink:BiologicalProcess obsolete xylitol export OBSOLETE. The directed movement of xylitol out of a cell or organelle. go.json True http://purl.obolibrary.org/obo/GO_1902342 GO:0060142 biolink:BiologicalProcess regulation of syncytium formation by plasma membrane fusion Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. go.json http://purl.obolibrary.org/obo/GO_0060142 GO:0060143 biolink:BiologicalProcess positive regulation of syncytium formation by plasma membrane fusion Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. go.json http://purl.obolibrary.org/obo/GO_0060143 GO:1902343 biolink:BiologicalProcess regulation of maltose transport Any process that modulates the frequency, rate or extent of maltose transport. go.json http://purl.obolibrary.org/obo/GO_1902343 GO:0060144 biolink:BiologicalProcess obsolete host cellular process involved in virus induced gene silencing OBSOLETE. A cellular process occurring in the host cell that contributes to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. go.json True http://purl.obolibrary.org/obo/GO_0060144 GO:1902351 biolink:BiologicalProcess response to imidacloprid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus. go.json http://purl.obolibrary.org/obo/GO_1902351 GO:0060145 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060145 GO:1902352 biolink:BiologicalProcess obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of filamentous growth of a population of unicellular organisms in response to starvation. go.json True http://purl.obolibrary.org/obo/GO_1902352 GO:0060146 biolink:BiologicalProcess obsolete host gene silencing in virus induced gene silencing OBSOLETE. The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection. go.json True http://purl.obolibrary.org/obo/GO_0060146 GO:1902350 biolink:BiologicalProcess cellular response to chloroquine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus. go.json http://purl.obolibrary.org/obo/GO_1902350 GO:0060147 biolink:BiologicalProcess regulation of post-transcriptional gene silencing Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. go.json regulation of posttranscriptional gene silencing http://purl.obolibrary.org/obo/GO_0060147 GO:0060148 biolink:BiologicalProcess positive regulation of post-transcriptional gene silencing Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. go.json positive regulation of posttranscriptional gene silencing http://purl.obolibrary.org/obo/GO_0060148 GO:0060149 biolink:BiologicalProcess negative regulation of post-transcriptional gene silencing Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. go.json negative regulation of posttranscriptional gene silencing http://purl.obolibrary.org/obo/GO_0060149 GO:0098778 biolink:BiologicalProcess curli subunit secretion coupled to curli assembly The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface. go.json extracellular nucleation-precipitation pathway http://purl.obolibrary.org/obo/GO_0098778 GO:0098779 biolink:BiologicalProcess positive regulation of mitophagy in response to mitochondrial depolarization Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. go.json positive regulation of macromitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_0098779 GO:0098776 biolink:BiologicalProcess protein transport across the cell outer membrane The directed movement of proteins across the cell outer membrane. go.json http://purl.obolibrary.org/obo/GO_0098776 GO:0098777 biolink:BiologicalProcess protein secretion by the type VIII secretion system Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits. go.json T8SS http://purl.obolibrary.org/obo/GO_0098777 GO:0001796 biolink:BiologicalProcess regulation of type IIa hypersensitivity Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0001796 GO:0098741 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098741 GO:0001797 biolink:BiologicalProcess negative regulation of type IIa hypersensitivity Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response. go.json down regulation of type IIa hypersensitivity|down-regulation of type IIa hypersensitivity|downregulation of type IIa hypersensitivity|inhibition of type IIa hypersensitivity http://purl.obolibrary.org/obo/GO_0001797 GO:0098742 biolink:BiologicalProcess cell-cell adhesion via plasma-membrane adhesion molecules The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0098742 GO:0001798 biolink:BiologicalProcess positive regulation of type IIa hypersensitivity Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response. go.json activation of type IIa hypersensitivity|stimulation of type IIa hypersensitivity|up regulation of type IIa hypersensitivity|up-regulation of type IIa hypersensitivity|upregulation of type IIa hypersensitivity http://purl.obolibrary.org/obo/GO_0001798 GO:0001799 biolink:BiologicalProcess regulation of type IIb hypersensitivity Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response. go.json http://purl.obolibrary.org/obo/GO_0001799 GO:0098740 biolink:BiologicalProcess obsolete multi organism cell adhesion OBSOLETE. Cell adhesion that involves cells from multiple organisms or that is mediated by gene products from multiple organisms. go.json True http://purl.obolibrary.org/obo/GO_0098740 GO:0001792 biolink:MolecularActivity polymeric immunoglobulin receptor activity Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001792 GO:0001793 biolink:MolecularActivity IgM receptor activity Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0001793 GO:0001794 biolink:BiologicalProcess type IIa hypersensitivity An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell. go.json http://purl.obolibrary.org/obo/GO_0001794 GO:0001795 biolink:BiologicalProcess type IIb hypersensitivity An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors. go.json type V hypersensitivity http://purl.obolibrary.org/obo/GO_0001795 GO:1902359 biolink:BiologicalProcess Notch signaling pathway involved in somitogenesis Any Notch signaling pathway that is involved in somitogenesis. go.json N signaling pathway involved in formation of mesodermal clusters|N signaling pathway involved in somitogenesis|N signalling pathway involved in formation of mesodermal clusters|N signalling pathway involved in somitogenesis|Notch receptor signaling pathway involved in formation of mesodermal clusters|Notch receptor signaling pathway involved in somitogenesis|Notch receptor signalling pathway involved in formation of mesodermal clusters|Notch receptor signalling pathway involved in somitogenesis|Notch signaling pathway involved in formation of mesodermal clusters|Notch signalling pathway involved in formation of mesodermal clusters|Notch signalling pathway involved in somitogenesis|Notch-receptor signaling pathway involved in formation of mesodermal clusters|Notch-receptor signaling pathway involved in somitogenesis|Notch-receptor signalling pathway involved in formation of mesodermal clusters|Notch-receptor signalling pathway involved in somitogenesis http://purl.obolibrary.org/obo/GO_1902359 GO:0060170 biolink:CellularComponent ciliary membrane The portion of the plasma membrane surrounding a cilium. go.json cilial membrane|cilium membrane|flagellar membrane|flagellum membrane http://purl.obolibrary.org/obo/GO_0060170 GO:0001790 biolink:MolecularActivity polymeric immunoglobulin binding Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes. go.json http://purl.obolibrary.org/obo/GO_0001790 GO:1902357 biolink:BiologicalProcess 2-isopropylmalate(2-) transmembrane transport The process in which 2-isopropylmalate(2-) is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902357 GO:0060171 biolink:CellularComponent stereocilium membrane The portion of the plasma membrane surrounding a stereocilium. go.json http://purl.obolibrary.org/obo/GO_0060171 GO:1902358 biolink:BiologicalProcess sulfate transmembrane transport The directed movement of sulfate across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902358 GO:0060172 biolink:BiologicalProcess astral microtubule depolymerization The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. go.json http://purl.obolibrary.org/obo/GO_0060172 GO:0001791 biolink:MolecularActivity IgM binding Binding to an immunoglobulin of the IgM isotype. go.json http://purl.obolibrary.org/obo/GO_0001791 GO:1902355 biolink:BiologicalProcess endothelial tube lumen extension involved in blood vessel lumen ensheathment Any endothelial tube lumen extension that is involved in blood vessel lumen ensheathment. go.json http://purl.obolibrary.org/obo/GO_1902355 GO:0060173 biolink:BiologicalProcess limb development The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. Wikipedia:Limb_development go.json limb bud development|paired limb/fin development http://purl.obolibrary.org/obo/GO_0060173 GO:0060174 biolink:BiologicalProcess limb bud formation The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. go.json limb formation|limbbud formation http://purl.obolibrary.org/obo/GO_0060174 GO:1902356 biolink:BiologicalProcess oxaloacetate(2-) transmembrane transport The directed movement of oxaloacetate(2-) across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902356 GO:1902353 biolink:BiologicalProcess obsolete positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter by pheromones that results in positive regulation of induction of conjugation with cellular fusion. go.json up regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones|up-regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones|upregulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones True http://purl.obolibrary.org/obo/GO_1902353 GO:0060175 biolink:MolecularActivity brain-derived neurotrophic factor receptor activity Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json BDNF receptor activity|BDNF-activated receptor activity|brain-derived neurotrophic factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0060175 GO:1902354 biolink:BiologicalProcess blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment Any blood vessel endothelial cell delamination that is involved in blood vessel lumen ensheathment. go.json http://purl.obolibrary.org/obo/GO_1902354 GO:0060176 biolink:BiologicalProcess regulation of aggregation involved in sorocarp development Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. go.json http://purl.obolibrary.org/obo/GO_0060176 GO:1902362 biolink:BiologicalProcess melanocyte apoptotic process Any apoptotic process in a melanocyte, the main structural component of the epidermis. go.json melanocyte apoptosis|melanophore apoptosis|melanophore apoptotic process http://purl.obolibrary.org/obo/GO_1902362 GO:0060177 biolink:BiologicalProcess regulation of angiotensin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin. go.json regulation of angiotensin metabolism http://purl.obolibrary.org/obo/GO_0060177 GO:0060178 biolink:BiologicalProcess regulation of exocyst localization Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. go.json regulation of exocyst localisation http://purl.obolibrary.org/obo/GO_0060178 GO:1902363 biolink:BiologicalProcess regulation of protein localization to spindle pole body Any process that modulates the frequency, rate or extent of protein localization to spindle pole body. go.json regulation of protein localisation to spindle pole body http://purl.obolibrary.org/obo/GO_1902363 GO:0060179 biolink:BiologicalProcess male mating behavior The specific behavior of a male organism that is associated with reproduction. go.json http://purl.obolibrary.org/obo/GO_0060179 GO:1902360 biolink:BiologicalProcess obsolete conversion of ds siRNA to ss siRNA involved in gene silencing by small RNA OBSOLETE. Any conversion of ds siRNA to ss siRNA that is involved in gene silencing by small RNA. go.json conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA interference-like chromatin silencing|conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA-mediated chromatin silencing|conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA-mediated transcriptional silencing|conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNAi-directed chromatin silencing|conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNAi-like chromatin silencing|conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in chromatin silencing by small RNA|conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in small RNA-mediated heterochromatic silencing|conversion of ds siRNA to ss siRNA involved in RNA interference-like chromatin silencing|conversion of ds siRNA to ss siRNA involved in RNA-mediated chromatin silencing|conversion of ds siRNA to ss siRNA involved in RNA-mediated transcriptional silencing|conversion of ds siRNA to ss siRNA involved in RNAi-directed chromatin silencing|conversion of ds siRNA to ss siRNA involved in RNAi-like chromatin silencing|conversion of ds siRNA to ss siRNA involved in chromatin silencing by small RNA|conversion of ds siRNA to ss siRNA involved in small RNA-mediated heterochromatic silencing True http://purl.obolibrary.org/obo/GO_1902360 GO:1902361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902361 GO:0098749 biolink:BiologicalProcess cerebellar neuron development The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0098749 GO:0098747 biolink:BiologicalProcess slow, calcium ion-dependent exocytosis of neurotransmitter The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release. go.json http://purl.obolibrary.org/obo/GO_0098747 GO:0098748 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098748 GO:0098745 biolink:CellularComponent RNA decapping complex A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA. go.json Dcp1-Dcp2 complex http://purl.obolibrary.org/obo/GO_0098745 GO:0098746 biolink:BiologicalProcess fast, calcium ion-dependent exocytosis of neurotransmitter The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release. go.json synchronous, calcium ion-dependent exocytosis of neurotransmitter http://purl.obolibrary.org/obo/GO_0098746 GO:0098743 biolink:BiologicalProcess cell aggregation The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. go.json http://purl.obolibrary.org/obo/GO_0098743 GO:0098744 biolink:MolecularActivity 1-phosphatidylinositol 4-kinase activator activity Binds to and increases the activity of 1-phosphatidylinositol 4-kinase. go.json http://purl.obolibrary.org/obo/GO_0098744 GO:0098752 biolink:CellularComponent obsolete integral component of the cytoplasmic side of the plasma membrane OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0098752 GO:0098753 biolink:CellularComponent obsolete anchored component of the cytoplasmic side of the plasma membrane OBSOLETE. The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane. go.json True http://purl.obolibrary.org/obo/GO_0098753 GO:0098750 biolink:MolecularActivity FYXD domain binding Binding to a FXYD domain. go.json http://purl.obolibrary.org/obo/GO_0098750 GO:0098751 biolink:BiologicalProcess bone cell development The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0098751 gocheck_do_not_annotate GO:2001303 biolink:BiologicalProcess lipoxin A4 biosynthetic process The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. go.json LXA4 anabolism|LXA4 biosynthesis|LXA4 biosynthetic process|LXA4 formation|LXA4 synthesis|lipoxin A4 anabolism|lipoxin A4 biosynthesis|lipoxin A4 formation|lipoxin A4 synthesis http://purl.obolibrary.org/obo/GO_2001303 GO:2001304 biolink:BiologicalProcess lipoxin B4 metabolic process The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. go.json LXB4 metabolic process|LXB4 metabolism|lipoxin B4 metabolism http://purl.obolibrary.org/obo/GO_2001304 GO:0060160 biolink:BiologicalProcess negative regulation of dopamine receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. go.json negative regulation of dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060160 GO:2001305 biolink:BiologicalProcess xanthone-containing compound metabolic process The chemical reactions and pathways involving a xanthone-containing compound. go.json xanthone metabolism|xanthone-containing compound metabolism|xanthones metabolic process|xanthones metabolism http://purl.obolibrary.org/obo/GO_2001305 GO:1902368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902368 GO:2001306 biolink:BiologicalProcess lipoxin B4 biosynthetic process The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. go.json LXB4 anabolism|LXB4 biosynthesis|LXB4 biosynthetic process|LXB4 formation|LXB4 synthesis|lipoxin B4 anabolism|lipoxin B4 biosynthesis|lipoxin B4 formation|lipoxin B4 synthesis http://purl.obolibrary.org/obo/GO_2001306 GO:1902369 biolink:BiologicalProcess negative regulation of RNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. go.json down regulation of RNA breakdown|down regulation of RNA catabolic process|down regulation of RNA catabolism|down regulation of RNA degradation|down-regulation of RNA breakdown|down-regulation of RNA catabolic process|down-regulation of RNA catabolism|down-regulation of RNA degradation|downregulation of RNA breakdown|downregulation of RNA catabolic process|downregulation of RNA catabolism|downregulation of RNA degradation|inhibition of RNA breakdown|inhibition of RNA catabolic process|inhibition of RNA catabolism|inhibition of RNA degradation|negative regulation of RNA breakdown|negative regulation of RNA catabolism|negative regulation of RNA degradation http://purl.obolibrary.org/obo/GO_1902369 GO:0060161 biolink:BiologicalProcess positive regulation of dopamine receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. go.json positive regulation of dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060161 GO:1902366 biolink:BiologicalProcess regulation of Notch signaling pathway involved in somitogenesis Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis. go.json regulation of N signaling pathway involved in formation of mesodermal clusters|regulation of N signaling pathway involved in somitogenesis|regulation of N signalling pathway involved in formation of mesodermal clusters|regulation of N signalling pathway involved in somitogenesis|regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters|regulation of Notch receptor signaling pathway involved in somitogenesis|regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters|regulation of Notch receptor signalling pathway involved in somitogenesis|regulation of Notch signaling pathway involved in formation of mesodermal clusters|regulation of Notch signalling pathway involved in formation of mesodermal clusters|regulation of Notch signalling pathway involved in somitogenesis|regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters|regulation of Notch-receptor signaling pathway involved in somitogenesis|regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters|regulation of Notch-receptor signalling pathway involved in somitogenesis http://purl.obolibrary.org/obo/GO_1902366 GO:2001307 biolink:BiologicalProcess xanthone-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a xanthone-containing compound. go.json xanthone biosynthesis|xanthone biosynthetic process|xanthone-containing compound anabolism|xanthone-containing compound biosynthesis|xanthone-containing compound formation|xanthone-containing compound synthesis|xanthones anabolism|xanthones biosynthesis|xanthones biosynthetic process|xanthones formation|xanthones synthesis http://purl.obolibrary.org/obo/GO_2001307 GO:0060162 biolink:BiologicalProcess negative regulation of phospholipase C-activating dopamine receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway. go.json negative regulation of dopamine receptor, phospholipase C activating pathway|negative regulation of phospholipase C-activating dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060162 GO:1902367 biolink:BiologicalProcess negative regulation of Notch signaling pathway involved in somitogenesis Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis. go.json down regulation of N signaling pathway involved in formation of mesodermal clusters|down regulation of N signaling pathway involved in somitogenesis|down regulation of N signalling pathway involved in formation of mesodermal clusters|down regulation of N signalling pathway involved in somitogenesis|down regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters|down regulation of Notch receptor signaling pathway involved in somitogenesis|down regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters|down regulation of Notch receptor signalling pathway involved in somitogenesis|down regulation of Notch signaling pathway involved in formation of mesodermal clusters|down regulation of Notch signaling pathway involved in somitogenesis|down regulation of Notch signalling pathway involved in formation of mesodermal clusters|down regulation of Notch signalling pathway involved in somitogenesis|down regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters|down regulation of Notch-receptor signaling pathway involved in somitogenesis|down regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters|down regulation of Notch-receptor signalling pathway involved in somitogenesis|down-regulation of N signaling pathway involved in formation of mesodermal clusters|down-regulation of N signaling pathway involved in somitogenesis|down-regulation of N signalling pathway involved in formation of mesodermal clusters|down-regulation of N signalling pathway involved in somitogenesis|down-regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters|down-regulation of Notch receptor signaling pathway involved in somitogenesis|down-regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters|down-regulation of Notch receptor signalling pathway involved in somitogenesis|down-regulation of Notch signaling pathway involved in formation of mesodermal clusters|down-regulation of Notch signaling pathway involved in somitogenesis|down-regulation of Notch signalling pathway involved in formation of mesodermal clusters|down-regulation of Notch signalling pathway involved in somitogenesis|down-regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters|down-regulation of Notch-receptor signaling pathway involved in somitogenesis|down-regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters|down-regulation of Notch-receptor signalling pathway involved in somitogenesis|downregulation of N signaling pathway involved in formation of mesodermal clusters|downregulation of N signaling pathway involved in somitogenesis|downregulation of N signalling pathway involved in formation of mesodermal clusters|downregulation of N signalling pathway involved in somitogenesis|downregulation of Notch receptor signaling pathway involved in formation of mesodermal clusters|downregulation of Notch receptor signaling pathway involved in somitogenesis|downregulation of Notch receptor signalling pathway involved in formation of mesodermal clusters|downregulation of Notch receptor signalling pathway involved in somitogenesis|downregulation of Notch signaling pathway involved in formation of mesodermal clusters|downregulation of Notch signaling pathway involved in somitogenesis|downregulation of Notch signalling pathway involved in formation of mesodermal clusters|downregulation of Notch signalling pathway involved in somitogenesis|downregulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters|downregulation of Notch-receptor signaling pathway involved in somitogenesis|downregulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters|downregulation of Notch-receptor signalling pathway involved in somitogenesis|inhibition of N signaling pathway involved in formation of mesodermal clusters|inhibition of N signaling pathway involved in somitogenesis|inhibition of N signalling pathway involved in formation of mesodermal clusters|inhibition of N signalling pathway involved in somitogenesis|inhibition of Notch receptor signaling pathway involved in formation of mesodermal clusters|inhibition of Notch receptor signaling pathway involved in somitogenesis|inhibition of Notch receptor signalling pathway involved in formation of mesodermal clusters|inhibition of Notch receptor signalling pathway involved in somitogenesis|inhibition of Notch signaling pathway involved in formation of mesodermal clusters|inhibition of Notch signaling pathway involved in somitogenesis|inhibition of Notch signalling pathway involved in formation of mesodermal clusters|inhibition of Notch signalling pathway involved in somitogenesis|inhibition of Notch-receptor signaling pathway involved in formation of mesodermal clusters|inhibition of Notch-receptor signaling pathway involved in somitogenesis|inhibition of Notch-receptor signalling pathway involved in formation of mesodermal clusters|inhibition of Notch-receptor signalling pathway involved in somitogenesis|negative regulation of N signaling pathway involved in formation of mesodermal clusters|negative regulation of N signaling pathway involved in somitogenesis|negative regulation of N signalling pathway involved in formation of mesodermal clusters|negative regulation of N signalling pathway involved in somitogenesis|negative regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters|negative regulation of Notch receptor signaling pathway involved in somitogenesis|negative regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters|negative regulation of Notch receptor signalling pathway involved in somitogenesis|negative regulation of Notch signaling pathway involved in formation of mesodermal clusters|negative regulation of Notch signalling pathway involved in formation of mesodermal clusters|negative regulation of Notch signalling pathway involved in somitogenesis|negative regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters|negative regulation of Notch-receptor signaling pathway involved in somitogenesis|negative regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters|negative regulation of Notch-receptor signalling pathway involved in somitogenesis http://purl.obolibrary.org/obo/GO_1902367 GO:2001308 biolink:BiologicalProcess gliotoxin metabolic process The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. go.json gliotoxin metabolism http://purl.obolibrary.org/obo/GO_2001308 GO:0060163 biolink:BiologicalProcess subpallium neuron fate commitment The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon. go.json subpallium neuronal precursor fate commitment http://purl.obolibrary.org/obo/GO_0060163 GO:2001309 biolink:BiologicalProcess gliotoxin catabolic process The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. go.json gliotoxin breakdown|gliotoxin catabolism|gliotoxin degradation http://purl.obolibrary.org/obo/GO_2001309 GO:1902364 biolink:BiologicalProcess negative regulation of protein localization to spindle pole body Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to spindle pole body. go.json down regulation of protein localisation to spindle pole body|down regulation of protein localization to spindle pole body|down-regulation of protein localisation to spindle pole body|down-regulation of protein localization to spindle pole body|downregulation of protein localisation to spindle pole body|downregulation of protein localization to spindle pole body|inhibition of protein localisation to spindle pole body|inhibition of protein localization to spindle pole body|negative regulation of protein localisation to spindle pole body http://purl.obolibrary.org/obo/GO_1902364 GO:0060164 biolink:BiologicalProcess regulation of timing of neuron differentiation The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron. go.json http://purl.obolibrary.org/obo/GO_0060164 GO:1902365 biolink:BiologicalProcess positive regulation of protein localization to spindle pole body Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body. go.json activation of protein localisation to spindle pole body|activation of protein localization to spindle pole body|positive regulation of protein localisation to spindle pole body|up regulation of protein localisation to spindle pole body|up regulation of protein localization to spindle pole body|up-regulation of protein localisation to spindle pole body|up-regulation of protein localization to spindle pole body|upregulation of protein localisation to spindle pole body|upregulation of protein localization to spindle pole body http://purl.obolibrary.org/obo/GO_1902365 GO:0060165 biolink:BiologicalProcess regulation of timing of subpallium neuron differentiation The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon. go.json http://purl.obolibrary.org/obo/GO_0060165 GO:1902373 biolink:BiologicalProcess negative regulation of mRNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process. go.json down regulation of mRNA breakdown|down regulation of mRNA catabolic process|down regulation of mRNA catabolism|down regulation of mRNA decay|down regulation of mRNA degradation|down-regulation of mRNA breakdown|down-regulation of mRNA catabolic process|down-regulation of mRNA catabolism|down-regulation of mRNA decay|down-regulation of mRNA degradation|downregulation of mRNA breakdown|downregulation of mRNA catabolic process|downregulation of mRNA catabolism|downregulation of mRNA decay|downregulation of mRNA degradation|inhibition of mRNA breakdown|inhibition of mRNA catabolic process|inhibition of mRNA catabolism|inhibition of mRNA decay|inhibition of mRNA degradation|negative regulation of mRNA breakdown|negative regulation of mRNA catabolism|negative regulation of mRNA decay|negative regulation of mRNA degradation http://purl.obolibrary.org/obo/GO_1902373 GO:0060166 biolink:BiologicalProcess olfactory pit development The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx. go.json http://purl.obolibrary.org/obo/GO_0060166 GO:0060167 biolink:BiologicalProcess regulation of adenosine receptor signaling pathway Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. go.json regulation of adenosine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060167 GO:1902374 biolink:BiologicalProcess regulation of rRNA catabolic process Any process that modulates the frequency, rate or extent of rRNA catabolic process. go.json regulation of rRNA breakdown|regulation of rRNA catabolism|regulation of rRNA degradation http://purl.obolibrary.org/obo/GO_1902374 GO:1902371 biolink:BiologicalProcess negative regulation of tRNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process. go.json down regulation of tRNA breakdown|down regulation of tRNA catabolic process|down regulation of tRNA catabolism|down regulation of tRNA degradation|down-regulation of tRNA breakdown|down-regulation of tRNA catabolic process|down-regulation of tRNA catabolism|down-regulation of tRNA degradation|downregulation of tRNA breakdown|downregulation of tRNA catabolic process|downregulation of tRNA catabolism|downregulation of tRNA degradation|inhibition of tRNA breakdown|inhibition of tRNA catabolic process|inhibition of tRNA catabolism|inhibition of tRNA degradation|negative regulation of tRNA breakdown|negative regulation of tRNA catabolism|negative regulation of tRNA degradation http://purl.obolibrary.org/obo/GO_1902371 GO:0060168 biolink:BiologicalProcess positive regulation of adenosine receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. go.json positive regulation of adenosine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060168 GO:1902372 biolink:BiologicalProcess positive regulation of tRNA catabolic process Any process that activates or increases the frequency, rate or extent of tRNA catabolic process. go.json activation of tRNA breakdown|activation of tRNA catabolic process|activation of tRNA catabolism|activation of tRNA degradation|positive regulation of tRNA breakdown|positive regulation of tRNA catabolism|positive regulation of tRNA degradation|up regulation of tRNA breakdown|up regulation of tRNA catabolic process|up regulation of tRNA catabolism|up regulation of tRNA degradation|up-regulation of tRNA breakdown|up-regulation of tRNA catabolic process|up-regulation of tRNA catabolism|up-regulation of tRNA degradation|upregulation of tRNA breakdown|upregulation of tRNA catabolic process|upregulation of tRNA catabolism|upregulation of tRNA degradation http://purl.obolibrary.org/obo/GO_1902372 GO:0060169 biolink:BiologicalProcess negative regulation of adenosine receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. go.json negative regulation of adenosine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060169 GO:1902370 biolink:BiologicalProcess regulation of tRNA catabolic process Any process that modulates the frequency, rate or extent of tRNA catabolic process. go.json regulation of tRNA breakdown|regulation of tRNA catabolism|regulation of tRNA degradation http://purl.obolibrary.org/obo/GO_1902370 GO:2001300 biolink:BiologicalProcess lipoxin metabolic process The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid. go.json lipoxin metabolism http://purl.obolibrary.org/obo/GO_2001300 GO:2001301 biolink:BiologicalProcess lipoxin biosynthetic process The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid. go.json lipoxin anabolism|lipoxin biosynthesis|lipoxin formation|lipoxin synthesis http://purl.obolibrary.org/obo/GO_2001301 GO:2001302 biolink:BiologicalProcess lipoxin A4 metabolic process The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. go.json LXA4 metabolic process|LXA4 metabolism|lipoxin A4 metabolism http://purl.obolibrary.org/obo/GO_2001302 GO:0098758 biolink:BiologicalProcess response to interleukin-8 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. go.json response to IL-8 http://purl.obolibrary.org/obo/GO_0098758 GO:0098759 biolink:BiologicalProcess cellular response to interleukin-8 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. go.json cellular response to IL-8 http://purl.obolibrary.org/obo/GO_0098759 GO:0098756 biolink:BiologicalProcess response to interleukin-21 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus. go.json response to IL-21 http://purl.obolibrary.org/obo/GO_0098756 GO:0098757 biolink:BiologicalProcess cellular response to interleukin-21 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus. go.json cellular response to IL-21 http://purl.obolibrary.org/obo/GO_0098757 GO:0098754 biolink:BiologicalProcess detoxification Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. go.json http://purl.obolibrary.org/obo/GO_0098754 goslim_generic|goslim_pombe|prokaryote_subset GO:0098755 biolink:BiologicalProcess maintenance of seed dormancy by absisic acid The process by which seed dormancy is maintained by the presence of absisic acid. go.json http://purl.obolibrary.org/obo/GO_0098755 GO:0050701 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050701 GO:0050702 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050702 GO:0050700 biolink:MolecularActivity CARD domain binding Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. go.json http://purl.obolibrary.org/obo/GO_0050700 GO:0050705 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050705 GO:0050706 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050706 GO:0050703 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050703 GO:0050704 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050704 GO:0050709 biolink:BiologicalProcess negative regulation of protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. go.json down regulation of protein secretion|down-regulation of protein secretion|downregulation of protein secretion|inhibition of protein secretion http://purl.obolibrary.org/obo/GO_0050709 GO:0050707 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050707 GO:0050708 biolink:BiologicalProcess regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. go.json http://purl.obolibrary.org/obo/GO_0050708 GO:0050712 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050712 GO:0050713 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050713 GO:0050710 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050710 GO:0050711 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050711 GO:0050716 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050716 GO:0050717 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050717 GO:0050714 biolink:BiologicalProcess positive regulation of protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. go.json activation of protein secretion|stimulation of protein secretion|up regulation of protein secretion|up-regulation of protein secretion|upregulation of protein secretion http://purl.obolibrary.org/obo/GO_0050714 GO:0050715 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050715 GO:0050718 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050718 GO:0050719 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050719 GO:0050720 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050720 GO:0050723 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050723 GO:0050724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050724 GO:0050721 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050721 GO:0050722 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050722 GO:0050727 biolink:BiologicalProcess regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. go.json http://purl.obolibrary.org/obo/GO_0050727 GO:0050728 biolink:BiologicalProcess negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. go.json anti-inflammatory response|down regulation of inflammatory response|down-regulation of inflammatory response|downregulation of inflammatory response|inhibition of inflammatory response http://purl.obolibrary.org/obo/GO_0050728 GO:0050725 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050725 GO:0050726 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050726 GO:0050729 biolink:BiologicalProcess positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response. go.json activation of inflammatory response|stimulation of inflammatory response|up regulation of inflammatory response|up-regulation of inflammatory response|upregulation of inflammatory response http://purl.obolibrary.org/obo/GO_0050729 GO:0050730 biolink:BiologicalProcess regulation of peptidyl-tyrosine phosphorylation Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. go.json http://purl.obolibrary.org/obo/GO_0050730 GO:0050731 biolink:BiologicalProcess positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. go.json activation of peptidyl-tyrosine phosphorylation|stimulation of peptidyl-tyrosine phosphorylation|up regulation of peptidyl-tyrosine phosphorylation|up-regulation of peptidyl-tyrosine phosphorylation|upregulation of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0050731 GO:0050734 biolink:MolecularActivity hydroxycinnamoyltransferase activity Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0050734 GO:0050735 biolink:MolecularActivity N-malonyltransferase activity Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0050735 GO:0050732 biolink:BiologicalProcess negative regulation of peptidyl-tyrosine phosphorylation Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. go.json down regulation of peptidyl-tyrosine phosphorylation|down-regulation of peptidyl-tyrosine phosphorylation|downregulation of peptidyl-tyrosine phosphorylation|inhibition of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0050732 GO:0050733 biolink:MolecularActivity RS domain binding Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. go.json http://purl.obolibrary.org/obo/GO_0050733 GO:0050738 biolink:MolecularActivity fructosyltransferase activity Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid. go.json http://purl.obolibrary.org/obo/GO_0050738 GO:0050739 biolink:BiologicalProcess peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. RESID:AA0348 go.json http://purl.obolibrary.org/obo/GO_0050739 gocheck_do_not_annotate GO:0050736 biolink:MolecularActivity O-malonyltransferase activity Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0050736 GO:0050737 biolink:MolecularActivity O-hydroxycinnamoyltransferase activity Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0050737 GO:0035199 biolink:BiologicalProcess salt aversion The specific avoidance actions or reactions of an organism in response to the perception of salt. go.json behavioral response to salt http://purl.obolibrary.org/obo/GO_0035199 GO:0035191 biolink:BiologicalProcess nuclear axial expansion The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex. go.json nuclear distribution along anterior-posterior axis|nucleus distribution along anterior-posterior axis http://purl.obolibrary.org/obo/GO_0035191 GO:0035192 biolink:BiologicalProcess nuclear cortical migration The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo. go.json http://purl.obolibrary.org/obo/GO_0035192 GO:0035193 biolink:BiologicalProcess larval central nervous system remodeling Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster. go.json CNS metamorphosis|central nervous system metamorphosis|larval central nervous system remodelling http://purl.obolibrary.org/obo/GO_0035193 GO:0035194 biolink:BiologicalProcess regulatory ncRNA-mediated post-transcriptional gene silencing A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. Wikipedia:RNA_interference go.json PTGS|RNA interference|RNA-dependent post-transcriptional gene silencing|RNA-mediated post-transcriptional gene silencing|RNA-mediated posttranscriptional gene silencing|RNAi|cosuppression|ncRNA-mediated post-transcriptional gene silencing|post-transcriptional gene silencing by RNA|posttranscriptional gene silencing by RNA|quelling http://purl.obolibrary.org/obo/GO_0035194 GO:0035195 biolink:BiologicalProcess miRNA-mediated post-transcriptional gene silencing A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. go.json gene silencing by miRNA|gene silencing by microRNA|miRNA-mediated gene silencing|microRNA-mediated gene silencing http://purl.obolibrary.org/obo/GO_0035195 GO:0035196 biolink:BiologicalProcess miRNA processing A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts. go.json gene silencing by miRNA, production of miRNAs|miRNA biogenesis|miRNA biosynthetic process|miRNA maturation|miRNA-mediated gene silencing, production of miRNAs|microRNA biogenesis|microRNA biosynthesis|microRNA biosynthetic process|microRNA metabolic process|microRNA metabolism|microRNA processing|microRNA-mediated gene silencing, production of microRNAs|production of miRNAs involved in gene silencing by miRNA|production of microRNAs involved in gene silencing by microRNA http://purl.obolibrary.org/obo/GO_0035196 GO:0035197 biolink:MolecularActivity siRNA binding Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. go.json small interfering RNA binding http://purl.obolibrary.org/obo/GO_0035197 GO:0035198 biolink:MolecularActivity miRNA binding Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. go.json microRNA binding http://purl.obolibrary.org/obo/GO_0035198 GO:0050741 biolink:BiologicalProcess obsolete protein-FMN linkage via O3-riboflavin phosphoryl-L-serine OBSOLETE. The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine. RESID:AA0350 go.json True http://purl.obolibrary.org/obo/GO_0050741 GO:0050742 biolink:BiologicalProcess obsolete protein-FMN linkage via S-(4a-FMN)-L-cysteine OBSOLETE. The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine. RESID:AA0351 go.json True http://purl.obolibrary.org/obo/GO_0050742 GO:0050740 biolink:BiologicalProcess obsolete protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine OBSOLETE. The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine. RESID:AA0349 go.json True http://purl.obolibrary.org/obo/GO_0050740 GO:0050745 biolink:BiologicalProcess peptide cross-linking via L-cysteinyl-5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. RESID:AA0188 go.json http://purl.obolibrary.org/obo/GO_0050745 gocheck_do_not_annotate GO:0050746 biolink:BiologicalProcess regulation of lipoprotein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. go.json regulation of lipoprotein metabolism http://purl.obolibrary.org/obo/GO_0050746 GO:0050743 biolink:BiologicalProcess obsolete protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine OBSOLETE. The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine. RESID:AA0352 go.json True http://purl.obolibrary.org/obo/GO_0050743 GO:0050744 biolink:BiologicalProcess obsolete protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine OBSOLETE. The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine. RESID:AA0353 go.json True http://purl.obolibrary.org/obo/GO_0050744 GO:0035190 biolink:BiologicalProcess syncytial nuclear migration The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. go.json http://purl.obolibrary.org/obo/GO_0035190 GO:0050749 biolink:MolecularActivity obsolete apolipoprotein E receptor binding OBSOLETE. Interacting selectively with an apolipoprotein E receptor. go.json apolipoprotein E receptor binding True http://purl.obolibrary.org/obo/GO_0050749 GO:0050747 biolink:BiologicalProcess positive regulation of lipoprotein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. go.json activation of lipoprotein metabolic process|positive regulation of lipoprotein metabolism|stimulation of lipoprotein metabolic process|up regulation of lipoprotein metabolic process|up-regulation of lipoprotein metabolic process|upregulation of lipoprotein metabolic process http://purl.obolibrary.org/obo/GO_0050747 GO:0050748 biolink:BiologicalProcess negative regulation of lipoprotein metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. go.json down regulation of lipoprotein metabolic process|down-regulation of lipoprotein metabolic process|downregulation of lipoprotein metabolic process|inhibition of lipoprotein metabolic process|negative regulation of lipoprotein metabolism http://purl.obolibrary.org/obo/GO_0050748 GO:0035188 biolink:BiologicalProcess hatching The emergence of an immature organism from a protective structure. go.json http://purl.obolibrary.org/obo/GO_0035188 GO:0035189 biolink:CellularComponent Rb-E2F complex A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. go.json retinoblastoma-E2F complex http://purl.obolibrary.org/obo/GO_0035189 GO:0035180 biolink:BiologicalProcess larval wandering behavior The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction. go.json larval wandering behaviour http://purl.obolibrary.org/obo/GO_0035180 GO:0035181 biolink:BiologicalProcess larval burrowing behavior Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation. go.json larval burrowing behaviour http://purl.obolibrary.org/obo/GO_0035181 GO:0035182 biolink:CellularComponent female germline ring canal outer rim An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues. go.json germline ring canal outer rim|nurse cell ring canal outer rim|ovarian ring canal outer rim http://purl.obolibrary.org/obo/GO_0035182 GO:0035183 biolink:CellularComponent female germline ring canal inner rim A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins. go.json germline ring canal inner rim|nurse cell ring canal inner rim|ovarian ring canal inner rim http://purl.obolibrary.org/obo/GO_0035183 GO:0035184 biolink:MolecularActivity obsolete histone threonine kinase activity OBSOLETE. Catalysis of the transfer of a phosphate group to a threonine residue of a histone. go.json histone-threonine kinase activity True http://purl.obolibrary.org/obo/GO_0035184 GO:0035185 biolink:BiologicalProcess preblastoderm mitotic cell cycle The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0035185 GO:0035186 biolink:BiologicalProcess syncytial blastoderm mitotic cell cycle Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively. go.json http://purl.obolibrary.org/obo/GO_0035186 GO:0035187 biolink:BiologicalProcess hatching behavior The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell. go.json hatching behaviour http://purl.obolibrary.org/obo/GO_0035187 GO:0050752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050752 GO:0050753 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050753 GO:0050750 biolink:MolecularActivity low-density lipoprotein particle receptor binding Binding to a low-density lipoprotein receptor. go.json LDL receptor binding|low-density lipoprotein receptor binding http://purl.obolibrary.org/obo/GO_0050750 GO:0050751 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050751 GO:0050756 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050756 GO:0050757 biolink:BiologicalProcess obsolete thymidylate synthase biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. go.json thymidylate synthase anabolism|thymidylate synthase biosynthesis|thymidylate synthase formation|thymidylate synthase synthesis True http://purl.obolibrary.org/obo/GO_0050757 GO:0050754 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050754 GO:0050755 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050755 GO:0050758 biolink:BiologicalProcess obsolete regulation of thymidylate synthase biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. go.json regulation of thymidylate synthase anabolism|regulation of thymidylate synthase biosynthesis|regulation of thymidylate synthase formation|regulation of thymidylate synthase synthesis True http://purl.obolibrary.org/obo/GO_0050758 GO:0050759 biolink:BiologicalProcess obsolete positive regulation of thymidylate synthase biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. go.json activation of thymidylate synthase biosynthetic process|positive regulation of thymidylate synthase anabolism|positive regulation of thymidylate synthase biosynthesis|positive regulation of thymidylate synthase formation|positive regulation of thymidylate synthase synthesis|stimulation of thymidylate synthase biosynthetic process|up regulation of thymidylate synthase biosynthetic process|up-regulation of thymidylate synthase biosynthetic process|upregulation of thymidylate synthase biosynthetic process True http://purl.obolibrary.org/obo/GO_0050759 GO:0035177 biolink:BiologicalProcess larval foraging behavior The movement of a larva through a feeding substrate whilst feeding on food. go.json larval foraging behaviour http://purl.obolibrary.org/obo/GO_0035177 GO:0035178 biolink:BiologicalProcess turning behavior Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source. go.json turning behaviour http://purl.obolibrary.org/obo/GO_0035178 GO:0035179 biolink:BiologicalProcess larval turning behavior Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source. go.json larval turning behaviour http://purl.obolibrary.org/obo/GO_0035179 GO:0035170 biolink:BiologicalProcess lymph gland crystal cell differentiation The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. go.json http://purl.obolibrary.org/obo/GO_0035170 GO:0035171 biolink:BiologicalProcess lamellocyte differentiation The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. go.json lamellocyte cell differentiation http://purl.obolibrary.org/obo/GO_0035171 GO:0035172 biolink:BiologicalProcess hemocyte proliferation The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. go.json arthropod blood cell proliferation http://purl.obolibrary.org/obo/GO_0035172 GO:0035173 biolink:MolecularActivity histone kinase activity Catalysis of the transfer of a phosphate group to a histone. go.json http://purl.obolibrary.org/obo/GO_0035173 GO:0035174 biolink:MolecularActivity obsolete histone serine kinase activity OBSOLETE. Catalysis of the transfer of a phosphate group to a serine residue of a histone. go.json histone-serine kinase activity True http://purl.obolibrary.org/obo/GO_0035174 GO:0035175 biolink:MolecularActivity histone H3S10 kinase activity Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3. go.json histone kinase activity (H3-S10 specific)|histone serine kinase activity (H3-S10 specific)|histone-serine kinase activity (H3-S10 specific) http://purl.obolibrary.org/obo/GO_0035175 GO:0035176 biolink:BiologicalProcess social behavior Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. Wikipedia:Social_behavior go.json cooperative behavior|social behaviour http://purl.obolibrary.org/obo/GO_0035176 GO:0050763 biolink:BiologicalProcess depsipeptide biosynthetic process The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. go.json depsipeptide anabolism|depsipeptide biosynthesis|depsipeptide formation|depsipeptide synthesis http://purl.obolibrary.org/obo/GO_0050763 GO:0050764 biolink:BiologicalProcess regulation of phagocytosis Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. go.json http://purl.obolibrary.org/obo/GO_0050764 GO:0050761 biolink:BiologicalProcess depsipeptide metabolic process The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. go.json depsipeptide metabolism http://purl.obolibrary.org/obo/GO_0050761 goslim_pir GO:0050762 biolink:BiologicalProcess depsipeptide catabolic process The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. go.json depsipeptide breakdown|depsipeptide catabolism|depsipeptide degradation http://purl.obolibrary.org/obo/GO_0050762 GO:0050767 biolink:BiologicalProcess regulation of neurogenesis Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. go.json http://purl.obolibrary.org/obo/GO_0050767 GO:0050768 biolink:BiologicalProcess negative regulation of neurogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. go.json down regulation of neurogenesis|down-regulation of neurogenesis|downregulation of neurogenesis|inhibition of neurogenesis http://purl.obolibrary.org/obo/GO_0050768 GO:0050765 biolink:BiologicalProcess negative regulation of phagocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. go.json down regulation of phagocytosis|down-regulation of phagocytosis|downregulation of phagocytosis|inhibition of phagocytosis http://purl.obolibrary.org/obo/GO_0050765 GO:0050766 biolink:BiologicalProcess positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis. go.json activation of phagocytosis|stimulation of phagocytosis|up regulation of phagocytosis|up-regulation of phagocytosis|upregulation of phagocytosis http://purl.obolibrary.org/obo/GO_0050766 GO:0050769 biolink:BiologicalProcess positive regulation of neurogenesis Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. go.json activation of neurogenesis|stimulation of neurogenesis|up regulation of neurogenesis|up-regulation of neurogenesis|upregulation of neurogenesis http://purl.obolibrary.org/obo/GO_0050769 GO:0035166 biolink:BiologicalProcess post-embryonic hemopoiesis The stages of blood cell formation that take place after completion of embryonic development. go.json post-embryonic haemopoiesis http://purl.obolibrary.org/obo/GO_0035166 GO:0035167 biolink:BiologicalProcess larval lymph gland hemopoiesis The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. go.json larval lymph gland haematopoiesis|larval lymph gland haemopoiesis|larval lymph gland hematopoiesis http://purl.obolibrary.org/obo/GO_0035167 GO:0035168 biolink:BiologicalProcess larval lymph gland hemocyte differentiation The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster. go.json larval lymph gland arthropod blood cell differentiation http://purl.obolibrary.org/obo/GO_0035168 GO:0035169 biolink:BiologicalProcess lymph gland plasmatocyte differentiation The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. go.json lymph gland plasmatocyte cell differentiation http://purl.obolibrary.org/obo/GO_0035169 GO:0035160 biolink:BiologicalProcess maintenance of epithelial integrity, open tracheal system Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process. go.json maintenance of tracheal epithelial integrity http://purl.obolibrary.org/obo/GO_0035160 GO:0035161 biolink:BiologicalProcess imaginal disc lineage restriction Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment. go.json http://purl.obolibrary.org/obo/GO_0035161 GO:0035162 biolink:BiologicalProcess embryonic hemopoiesis The stages of blood cell formation that take place within the embryo. go.json embryonic haematopoiesis|embryonic haemopoiesis|embryonic hematopoiesis http://purl.obolibrary.org/obo/GO_0035162 GO:0050760 biolink:BiologicalProcess obsolete negative regulation of thymidylate synthase biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. go.json down regulation of thymidylate synthase biosynthetic process|down-regulation of thymidylate synthase biosynthetic process|downregulation of thymidylate synthase biosynthetic process|inhibition of thymidylate synthase biosynthetic process|negative regulation of thymidylate synthase anabolism|negative regulation of thymidylate synthase biosynthesis|negative regulation of thymidylate synthase formation|negative regulation of thymidylate synthase synthesis True http://purl.obolibrary.org/obo/GO_0050760 GO:0035163 biolink:BiologicalProcess embryonic hemocyte differentiation The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. go.json embryonic arthropod blood cell differentiation|embryonic hemocyte cell differentiation http://purl.obolibrary.org/obo/GO_0035163 GO:0035164 biolink:BiologicalProcess embryonic plasmatocyte differentiation The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. go.json embryonic plasmatocyte cell differentiation http://purl.obolibrary.org/obo/GO_0035164 GO:0035165 biolink:BiologicalProcess embryonic crystal cell differentiation The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. go.json http://purl.obolibrary.org/obo/GO_0035165 GO:0050774 biolink:BiologicalProcess negative regulation of dendrite morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. go.json down regulation of dendrite morphogenesis|down-regulation of dendrite morphogenesis|downregulation of dendrite morphogenesis|inhibition of dendrite morphogenesis http://purl.obolibrary.org/obo/GO_0050774 GO:0050775 biolink:BiologicalProcess positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. go.json activation of dendrite morphogenesis|stimulation of dendrite morphogenesis|up regulation of dendrite morphogenesis|up-regulation of dendrite morphogenesis|upregulation of dendrite morphogenesis http://purl.obolibrary.org/obo/GO_0050775 GO:0050772 biolink:BiologicalProcess positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis. go.json activation of axonogenesis|stimulation of axonogenesis|up regulation of axonogenesis|up-regulation of axonogenesis|upregulation of axonogenesis http://purl.obolibrary.org/obo/GO_0050772 GO:0050773 biolink:BiologicalProcess regulation of dendrite development Any process that modulates the frequency, rate or extent of dendrite development. go.json http://purl.obolibrary.org/obo/GO_0050773 GO:0050778 biolink:BiologicalProcess positive regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. go.json stimulation of immune response|up regulation of immune response|up-regulation of immune response|upregulation of immune response http://purl.obolibrary.org/obo/GO_0050778 GO:0050779 biolink:BiologicalProcess RNA destabilization Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. go.json http://purl.obolibrary.org/obo/GO_0050779 GO:0050776 biolink:BiologicalProcess regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. go.json http://purl.obolibrary.org/obo/GO_0050776 GO:0050777 biolink:BiologicalProcess negative regulation of immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. go.json down regulation of immune response|down-regulation of immune response|downregulation of immune response|inhibition of immune response http://purl.obolibrary.org/obo/GO_0050777 GO:0035155 biolink:BiologicalProcess negative regulation of terminal cell fate specification, open tracheal system Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. go.json down regulation of terminal cell fate specification|down-regulation of terminal cell fate specification|downregulation of terminal cell fate specification|inhibition of terminal cell fate specification|negative regulation of terminal cell fate specification http://purl.obolibrary.org/obo/GO_0035155 GO:0035156 biolink:BiologicalProcess fusion cell fate specification The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion. go.json http://purl.obolibrary.org/obo/GO_0035156 GO:0035157 biolink:BiologicalProcess negative regulation of fusion cell fate specification Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. go.json down regulation of fusion cell fate specification|down-regulation of fusion cell fate specification|downregulation of fusion cell fate specification|inhibition of fusion cell fate specification http://purl.obolibrary.org/obo/GO_0035157 GO:0035158 biolink:BiologicalProcess regulation of tube diameter, open tracheal system Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size. go.json regulation of tracheal tube diameter|tracheal tube dilation|tracheal tube expansion http://purl.obolibrary.org/obo/GO_0035158 GO:0035159 biolink:BiologicalProcess regulation of tube length, open tracheal system Ensuring that a tube in an open tracheal system is of the correct length. go.json regulation of tracheal tube length|tracheal tube elongation http://purl.obolibrary.org/obo/GO_0035159 GO:0035150 biolink:BiologicalProcess regulation of tube size Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes. go.json http://purl.obolibrary.org/obo/GO_0035150 GO:0050770 biolink:BiologicalProcess regulation of axonogenesis Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. go.json http://purl.obolibrary.org/obo/GO_0050770 GO:0035151 biolink:BiologicalProcess regulation of tube size, open tracheal system Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape. go.json regulation of tracheal tube size http://purl.obolibrary.org/obo/GO_0035151 GO:0050771 biolink:BiologicalProcess negative regulation of axonogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. go.json down regulation of axonogenesis|down-regulation of axonogenesis|downregulation of axonogenesis|inhibition of axonogenesis http://purl.obolibrary.org/obo/GO_0050771 GO:0035152 biolink:BiologicalProcess regulation of tube architecture, open tracheal system Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network. go.json regulation of tracheal tube architecture http://purl.obolibrary.org/obo/GO_0035152 GO:0035153 biolink:BiologicalProcess epithelial cell type specification, open tracheal system Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions. go.json tracheal cell type specification|tracheal epithelial cell type specification http://purl.obolibrary.org/obo/GO_0035153 GO:0035154 biolink:BiologicalProcess terminal cell fate specification, open tracheal system The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange. go.json terminal cell fate specification http://purl.obolibrary.org/obo/GO_0035154 GO:0001930 biolink:BiologicalProcess positive regulation of exocyst assembly Any process that increases the rate or extent of exocyst assembly. go.json activation of exocyst assembly|stimulation of exocyst assembly|up regulation of exocyst assembly|up-regulation of exocyst assembly|upregulation of exocyst assembly http://purl.obolibrary.org/obo/GO_0001930 GO:0001931 biolink:CellularComponent uropod A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. go.json distal pole complex|retractile pole|uropodium http://purl.obolibrary.org/obo/GO_0001931 GO:0001936 biolink:BiologicalProcess regulation of endothelial cell proliferation Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0001936 GO:0001937 biolink:BiologicalProcess negative regulation of endothelial cell proliferation Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. go.json down regulation of endothelial cell proliferation|down-regulation of endothelial cell proliferation|downregulation of endothelial cell proliferation|inhibition of endothelial cell proliferation http://purl.obolibrary.org/obo/GO_0001937 GO:0001938 biolink:BiologicalProcess positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation. go.json activation of endothelial cell proliferation|stimulation of endothelial cell proliferation|up regulation of endothelial cell proliferation|up-regulation of endothelial cell proliferation|upregulation of endothelial cell proliferation http://purl.obolibrary.org/obo/GO_0001938 GO:0001939 biolink:CellularComponent female pronucleus The pronucleus originating from the ovum that is being fertilized. go.json http://purl.obolibrary.org/obo/GO_0001939 GO:0001932 biolink:BiologicalProcess regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. go.json regulation of protein amino acid phosphorylation http://purl.obolibrary.org/obo/GO_0001932 GO:0001933 biolink:BiologicalProcess negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. go.json down regulation of protein amino acid phosphorylation|down-regulation of protein amino acid phosphorylation|downregulation of protein amino acid phosphorylation|inhibition of protein amino acid phosphorylation|negative regulation of protein amino acid phosphorylation http://purl.obolibrary.org/obo/GO_0001933 GO:0001934 biolink:BiologicalProcess positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. go.json activation of protein amino acid phosphorylation|positive regulation of protein amino acid phosphorylation|stimulation of protein amino acid phosphorylation|up regulation of protein amino acid phosphorylation|up-regulation of protein amino acid phosphorylation|upregulation of protein amino acid phosphorylation http://purl.obolibrary.org/obo/GO_0001934 GO:0001935 biolink:BiologicalProcess endothelial cell proliferation The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. go.json http://purl.obolibrary.org/obo/GO_0001935 GO:0001940 biolink:CellularComponent male pronucleus The pronucleus originating from the spermatozoa that was involved in fertilization. go.json http://purl.obolibrary.org/obo/GO_0001940 GO:0001941 biolink:BiologicalProcess postsynaptic membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). go.json post-synaptic membrane organization|postsynaptic membrane organisation http://purl.obolibrary.org/obo/GO_0001941 GO:0001942 biolink:BiologicalProcess hair follicle development The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. go.json http://purl.obolibrary.org/obo/GO_0001942 GO:0001947 biolink:BiologicalProcess heart looping The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. go.json cardiac looping http://purl.obolibrary.org/obo/GO_0001947 GO:0001948 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001948 GO:0001949 biolink:BiologicalProcess sebaceous gland cell differentiation The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell. go.json sebocytes differentiation http://purl.obolibrary.org/obo/GO_0001949 GO:0001943 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001943 GO:0001944 biolink:BiologicalProcess vasculature development The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. go.json vascular system development http://purl.obolibrary.org/obo/GO_0001944 GO:0001945 biolink:BiologicalProcess lymph vessel development The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0001945 GO:0001946 biolink:BiologicalProcess lymphangiogenesis Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. Wikipedia:Lymphangiogenesis go.json lymph vessel formation http://purl.obolibrary.org/obo/GO_0001946 GO:0001918 biolink:MolecularActivity farnesylated protein binding Binding to a farnesylated protein. go.json http://purl.obolibrary.org/obo/GO_0001918 GO:0001919 biolink:BiologicalProcess regulation of receptor recycling Any process that modulates the frequency, rate, or extent of receptor recycling. go.json http://purl.obolibrary.org/obo/GO_0001919 GO:0001914 biolink:BiologicalProcess regulation of T cell mediated cytotoxicity Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. go.json regulation of T cell mediated apoptosis|regulation of T cell mediated cell death|regulation of T cell mediated cell killing|regulation of T cell mediated cytolysis|regulation of T lymphocyte mediated cytotoxicity|regulation of T-cell mediated apoptosis|regulation of T-cell mediated cell death|regulation of T-cell mediated cell killing|regulation of T-cell mediated cytolysis|regulation of T-cell mediated cytotoxicity|regulation of T-lymphocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001914 GO:0001915 biolink:BiologicalProcess negative regulation of T cell mediated cytotoxicity Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity. go.json down regulation of T cell mediated cytotoxicity|down-regulation of T cell mediated cytotoxicity|downregulation of T cell mediated cytotoxicity|inhibition of T cell mediated cytotoxicity|negative regulation of T cell mediated apoptosis|negative regulation of T cell mediated cell death|negative regulation of T cell mediated cell killing|negative regulation of T cell mediated cytolysis|negative regulation of T lymphocyte mediated cytotoxicity|negative regulation of T-cell mediated apoptosis|negative regulation of T-cell mediated cell death|negative regulation of T-cell mediated cell killing|negative regulation of T-cell mediated cytolysis|negative regulation of T-cell mediated cytotoxicity|negative regulation of T-lymphocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001915 GO:0001916 biolink:BiologicalProcess positive regulation of T cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. go.json activation of T cell mediated cytotoxicity|positive regulation of T cell mediated apoptosis|positive regulation of T cell mediated cell death|positive regulation of T cell mediated cell killing|positive regulation of T cell mediated cytolysis|positive regulation of T lymphocyte mediated cytotoxicity|positive regulation of T-cell mediated apoptosis|positive regulation of T-cell mediated cell death|positive regulation of T-cell mediated cell killing|positive regulation of T-cell mediated cytolysis|positive regulation of T-cell mediated cytotoxicity|positive regulation of T-lymphocyte mediated cytotoxicity|stimulation of T cell mediated cytotoxicity|up regulation of T cell mediated cytotoxicity|up-regulation of T cell mediated cytotoxicity|upregulation of T cell mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001916 GO:0001917 biolink:CellularComponent photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. go.json http://purl.obolibrary.org/obo/GO_0001917 goslim_pir GO:0001910 biolink:BiologicalProcess regulation of leukocyte mediated cytotoxicity Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. go.json regulation of immune cell mediated cell death|regulation of immune cell mediated cell killing|regulation of immune cell mediated cytotoxicity|regulation of leucocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001910 GO:0001911 biolink:BiologicalProcess negative regulation of leukocyte mediated cytotoxicity Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity. go.json down regulation of leukocyte mediated cytotoxicity|down-regulation of leukocyte mediated cytotoxicity|downregulation of leukocyte mediated cytotoxicity|inhibition of leukocyte mediated cytotoxicity|negative regulation of immune cell mediated cytotoxicity|negative regulation of leucocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001911 GO:0001912 biolink:BiologicalProcess positive regulation of leukocyte mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity. go.json activation of leukocyte mediated cytotoxicity|positive regulation of immune cell mediated cytotoxicity|positive regulation of leucocyte mediated cytotoxicity|stimulation of leukocyte mediated cytotoxicity|up regulation of leukocyte mediated cytotoxicity|up-regulation of leukocyte mediated cytotoxicity|upregulation of leukocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001912 GO:0001913 biolink:BiologicalProcess T cell mediated cytotoxicity The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. go.json T cell mediated apoptosis|T cell mediated cell death|T cell mediated cell killing|T cell mediated cytolysis|T lymphocyte mediated cytotoxicity|T-cell mediated apoptosis|T-cell mediated cell death|T-cell mediated cell killing|T-cell mediated cytotoxicity|T-lymphocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001913 GO:0001920 biolink:BiologicalProcess negative regulation of receptor recycling Any process that stops, prevents, or reduces the rate of receptor recycling. go.json down regulation of receptor recycling|down-regulation of receptor recycling|downregulation of receptor recycling|inhibition of receptor recycling http://purl.obolibrary.org/obo/GO_0001920 GO:0001929 biolink:BiologicalProcess negative regulation of exocyst assembly Any process that stops, prevents, or reduces the rate or extent of exocyst assembly. go.json down regulation of exocyst assembly|down-regulation of exocyst assembly|downregulation of exocyst assembly|inhibition of exocyst assembly http://purl.obolibrary.org/obo/GO_0001929 GO:0001925 biolink:BiologicalProcess negative regulation of B-1 B cell differentiation Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation. go.json down regulation of B-1 B cell differentiation|down-regulation of B-1 B cell differentiation|downregulation of B-1 B cell differentiation|inhibition of B-1 B cell differentiation|negative regulation of B-1 B cell development|negative regulation of B-1 B lymphocyte differentiation|negative regulation of B-1 B-cell differentiation|negative regulation of B-1 B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0001925 GO:0001926 biolink:BiologicalProcess positive regulation of B-1 B cell differentiation Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation. go.json activation of B-1 B cell differentiation|positive regulation of B-1 B cell development|positive regulation of B-1 B lymphocyte differentiation|positive regulation of B-1 B-cell differentiation|positive regulation of B-1 B-lymphocyte differentiation|stimulation of B-1 B cell differentiation|up regulation of B-1 B cell differentiation|up-regulation of B-1 B cell differentiation|upregulation of B-1 B cell differentiation http://purl.obolibrary.org/obo/GO_0001926 GO:0001927 biolink:BiologicalProcess exocyst assembly The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex. go.json http://purl.obolibrary.org/obo/GO_0001927 GO:0001928 biolink:BiologicalProcess regulation of exocyst assembly Any process that modulates the frequency, rate or extent of exocyst assembly. go.json http://purl.obolibrary.org/obo/GO_0001928 GO:0001921 biolink:BiologicalProcess positive regulation of receptor recycling Any process that activates or increases the frequency, rate or extent of receptor recycling. go.json activation of receptor recycling|stimulation of receptor recycling|up regulation of receptor recycling|up-regulation of receptor recycling|upregulation of receptor recycling http://purl.obolibrary.org/obo/GO_0001921 GO:0001922 biolink:BiologicalProcess B-1 B cell homeostasis The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. go.json B-1 B lymphocyte homeostasis|B-1 B-cell homeostasis|B-1 B-lymphocyte homeostasis http://purl.obolibrary.org/obo/GO_0001922 GO:0001923 biolink:BiologicalProcess B-1 B cell differentiation The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. go.json B-1 B cell development|B-1 B lymphocyte differentiation|B-1 B-cell differentiation|B-1 B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0001923 GO:0001924 biolink:BiologicalProcess regulation of B-1 B cell differentiation Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. go.json regulation of B-1 B cell development|regulation of B-1 B lymphocyte differentiation|regulation of B-1 B-cell differentiation|regulation of B-1 B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0001924 GO:0050900 biolink:BiologicalProcess leukocyte migration The movement of a leukocyte within or between different tissues and organs of the body. go.json immune cell migration|immune cell trafficking|leucocyte migration|leucocyte trafficking|leukocyte trafficking http://purl.obolibrary.org/obo/GO_0050900 GO:0050903 biolink:BiologicalProcess leukocyte activation-dependent arrest The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation. go.json http://purl.obolibrary.org/obo/GO_0050903 GO:0050904 biolink:BiologicalProcess diapedesis The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. go.json http://purl.obolibrary.org/obo/GO_0050904 GO:0050901 biolink:BiologicalProcess leukocyte tethering or rolling Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). go.json http://purl.obolibrary.org/obo/GO_0050901 GO:0050902 biolink:BiologicalProcess leukocyte adhesive activation The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation. go.json leukocyte adhesive triggering http://purl.obolibrary.org/obo/GO_0050902 GO:0050907 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. go.json sensory detection of chemical stimulus|sensory detection of chemical stimulus during sensory perception|sensory perception, sensory detection of chemical stimulus|sensory perception, sensory transduction of chemical stimulus|sensory transduction of chemical stimulus|sensory transduction of chemical stimulus during sensory perception http://purl.obolibrary.org/obo/GO_0050907 GO:0050908 biolink:BiologicalProcess detection of light stimulus involved in visual perception The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. go.json sensory detection of light during visual perception|sensory detection of light stimulus during visual perception|sensory transduction of light during visual perception|sensory transduction of light stimulus during visual perception|visual perception, detection of light stimulus|visual perception, sensory transduction during perception of light|visual perception, sensory transduction of light stimulus http://purl.obolibrary.org/obo/GO_0050908 GO:0050905 biolink:BiologicalProcess neuromuscular process Any process pertaining to the functions of the nervous and muscular systems of an organism. go.json neuromotor process|neuromuscular physiological process http://purl.obolibrary.org/obo/GO_0050905 GO:0050906 biolink:BiologicalProcess detection of stimulus involved in sensory perception The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. Wikipedia:Transduction_(physiology) go.json sensory detection of stimulus|sensory perception, sensory transduction of stimulus|sensory perception, stimulus detection|sensory transduction http://purl.obolibrary.org/obo/GO_0050906 GO:2001196 biolink:BiologicalProcess positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. go.json positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine|positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine http://purl.obolibrary.org/obo/GO_2001196 GO:2001197 biolink:BiologicalProcess basement membrane assembly involved in embryonic body morphogenesis Any basement membrane assembly that is involved in embryonic body morphogenesis. go.json http://purl.obolibrary.org/obo/GO_2001197 GO:2001198 biolink:BiologicalProcess regulation of dendritic cell differentiation Any process that modulates the frequency, rate or extent of dendritic cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001198 GO:2001199 biolink:BiologicalProcess negative regulation of dendritic cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001199 GO:2001190 biolink:BiologicalProcess positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. go.json positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell http://purl.obolibrary.org/obo/GO_2001190 GO:2001191 biolink:BiologicalProcess regulation of gamma-delta T cell activation involved in immune response Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response. go.json regulation of gamma-delta T cell activation during immune response|regulation of gamma-delta T lymphocyte activation during immune response|regulation of gamma-delta T-cell activation during immune response|regulation of gamma-delta T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_2001191 GO:2001192 biolink:BiologicalProcess negative regulation of gamma-delta T cell activation involved in immune response Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response. go.json negative regulation of gamma-delta T cell activation during immune response|negative regulation of gamma-delta T lymphocyte activation during immune response|negative regulation of gamma-delta T-cell activation during immune response|negative regulation of gamma-delta T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_2001192 GO:2001193 biolink:BiologicalProcess positive regulation of gamma-delta T cell activation involved in immune response Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response. go.json positive regulation of gamma-delta T cell activation during immune response|positive regulation of gamma-delta T lymphocyte activation during immune response|positive regulation of gamma-delta T-cell activation during immune response|positive regulation of gamma-delta T-lymphocyte activation during immune response http://purl.obolibrary.org/obo/GO_2001193 GO:2001194 biolink:BiologicalProcess regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. go.json regulation of lysine biosynthesis via aminoadipic acid and saccharopine|regulation of lysine biosynthetic process via aminoadipic acid and saccharopine http://purl.obolibrary.org/obo/GO_2001194 GO:2001195 biolink:BiologicalProcess negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. go.json negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine|negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine http://purl.obolibrary.org/obo/GO_2001195 GO:0050910 biolink:BiologicalProcess detection of mechanical stimulus involved in sensory perception of sound The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. go.json detection of sound|hearing, sensory transduction of sound|perception of sound, detection of mechanical stimulus|perception of sound, sensory detection of mechanical stimulus|perception of sound, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during perception of sound|sensory transduction of mechanical stimulus during perception of sound|sensory transduction of sound http://purl.obolibrary.org/obo/GO_0050910 GO:0050911 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of smell The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. go.json perception of smell, detection of chemical stimulus|perception of smell, sensory detection of chemical stimulus|perception of smell, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during perception of smell|sensory detection of scent|sensory detection of smell|sensory transduction of chemical stimulus during perception of smell|sensory transduction of scent|sensory transduction of smell http://purl.obolibrary.org/obo/GO_0050911 GO:0050914 biolink:BiologicalProcess sensory perception of salty taste The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json salty taste perception http://purl.obolibrary.org/obo/GO_0050914 GO:0050915 biolink:BiologicalProcess sensory perception of sour taste The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json sour taste perception http://purl.obolibrary.org/obo/GO_0050915 GO:0050912 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of taste The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. go.json perception of taste, detection of chemical stimulus|perception of taste, sensory detection of chemical stimulus|perception of taste, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during perception of taste|sensory detection of taste|sensory transduction of chemical stimulus during perception of taste|sensory transduction of taste|taste perception http://purl.obolibrary.org/obo/GO_0050912 GO:0050913 biolink:BiologicalProcess sensory perception of bitter taste The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json bitter taste perception http://purl.obolibrary.org/obo/GO_0050913 GO:0050918 biolink:BiologicalProcess positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical. go.json chemoattraction http://purl.obolibrary.org/obo/GO_0050918 GO:0050919 biolink:BiologicalProcess negative chemotaxis The directed movement of a motile cell or organism towards a lower concentration of a chemical. go.json chemoaversion|chemorepulsion http://purl.obolibrary.org/obo/GO_0050919 GO:0050916 biolink:BiologicalProcess sensory perception of sweet taste The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json sweet taste perception http://purl.obolibrary.org/obo/GO_0050916 GO:0050917 biolink:BiologicalProcess sensory perception of umami taste The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process. go.json umami taste perception http://purl.obolibrary.org/obo/GO_0050917 GO:0050909 biolink:BiologicalProcess sensory perception of taste The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. Wikipedia:Taste go.json gustation|sense of taste|taste|taste perception http://purl.obolibrary.org/obo/GO_0050909 GO:0001907 biolink:BiologicalProcess killing by symbiont of host cells Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json pathogenesis http://purl.obolibrary.org/obo/GO_0001907 GO:0001908 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001908 GO:0001909 biolink:BiologicalProcess leukocyte mediated cytotoxicity The directed killing of a target cell by a leukocyte. go.json immune cell mediated cell death|immune cell mediated cell killing|immune cell mediated cytotoxicity|leucocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001909 GO:0001903 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001903 GO:0001904 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001904 GO:0001905 biolink:BiologicalProcess activation of membrane attack complex The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis. go.json MAC assembly|MAC formation|activation of MAC|activation of TCC|activation of terminal complement complex|activation of the terminal complement cascade|membrane attack complex assembly|membrane attack complex formation http://purl.obolibrary.org/obo/GO_0001905 GO:0001906 biolink:BiologicalProcess cell killing Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. go.json necrosis http://purl.obolibrary.org/obo/GO_0001906 goslim_pir GO:0001900 biolink:BiologicalProcess obsolete positive regulation of cytolysis by symbiont of host cells OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of cytolysis of host cells|positive regulation by symbiont of cytolysis of host cells|stimulation by symbiont of cytolysis of host cells|up regulation by symbiont of cytolysis of host cells|up-regulation by symbiont of cytolysis of host cells|upregulation by symbiont of cytolysis of host cells True http://purl.obolibrary.org/obo/GO_0001900 GO:0001901 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001901 GO:0001902 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001902 GO:0050921 biolink:BiologicalProcess positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. go.json activation of chemotaxis|stimulation of chemotaxis|up regulation of chemotaxis|up-regulation of chemotaxis|upregulation of chemotaxis http://purl.obolibrary.org/obo/GO_0050921 GO:0050922 biolink:BiologicalProcess negative regulation of chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. go.json down regulation of chemotaxis|down-regulation of chemotaxis|downregulation of chemotaxis|inhibition of chemotaxis http://purl.obolibrary.org/obo/GO_0050922 GO:0050920 biolink:BiologicalProcess regulation of chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. go.json http://purl.obolibrary.org/obo/GO_0050920 GO:0050925 biolink:BiologicalProcess negative regulation of negative chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. go.json down regulation of negative chemotaxis|down-regulation of negative chemotaxis|downregulation of negative chemotaxis|inhibition of negative chemotaxis http://purl.obolibrary.org/obo/GO_0050925 GO:0050926 biolink:BiologicalProcess regulation of positive chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. go.json http://purl.obolibrary.org/obo/GO_0050926 GO:0050923 biolink:BiologicalProcess regulation of negative chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. go.json http://purl.obolibrary.org/obo/GO_0050923 GO:0050924 biolink:BiologicalProcess positive regulation of negative chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. go.json activation of negative chemotaxis|stimulation of negative chemotaxis|up regulation of negative chemotaxis|up-regulation of negative chemotaxis|upregulation of negative chemotaxis http://purl.obolibrary.org/obo/GO_0050924 GO:0050929 biolink:BiologicalProcess induction of negative chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. go.json http://purl.obolibrary.org/obo/GO_0050929 GO:0050927 biolink:BiologicalProcess positive regulation of positive chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. go.json activation of positive chemotaxis|stimulation of positive chemotaxis|up regulation of positive chemotaxis|up-regulation of positive chemotaxis|upregulation of positive chemotaxis http://purl.obolibrary.org/obo/GO_0050927 GO:0050928 biolink:BiologicalProcess negative regulation of positive chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. go.json down regulation of positive chemotaxis|down-regulation of positive chemotaxis|downregulation of positive chemotaxis|inhibition of positive chemotaxis http://purl.obolibrary.org/obo/GO_0050928 GO:0050932 biolink:BiologicalProcess regulation of pigment cell differentiation Any process that modulates the frequency, rate or extent of pigmented cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0050932 GO:0050933 biolink:BiologicalProcess early stripe melanocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development). go.json early stripe melanocyte cell differentiation|early stripe melanophore differentiation http://purl.obolibrary.org/obo/GO_0050933 GO:0050930 biolink:BiologicalProcess induction of positive chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. go.json http://purl.obolibrary.org/obo/GO_0050930 GO:0050931 biolink:BiologicalProcess pigment cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. go.json chromatophore differentiation|pigmented cell differentiation http://purl.obolibrary.org/obo/GO_0050931 GO:0050936 biolink:BiologicalProcess xanthophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance. go.json xanthophore cell differentiation http://purl.obolibrary.org/obo/GO_0050936 GO:0050937 biolink:BiologicalProcess regulation of iridophore differentiation Any process that modulates the frequency, rate or extent of iridophore differentiation. go.json http://purl.obolibrary.org/obo/GO_0050937 GO:0050934 biolink:BiologicalProcess late stripe melanocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development). go.json late stripe melanocyte cell differentiation|late stripe melanophore differentiation http://purl.obolibrary.org/obo/GO_0050934 GO:0050935 biolink:BiologicalProcess iridophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance. go.json iridophore cell differentiation http://purl.obolibrary.org/obo/GO_0050935 GO:0050938 biolink:BiologicalProcess regulation of xanthophore differentiation Any process that modulates the frequency, rate or extent of xanthophore differentiation. go.json http://purl.obolibrary.org/obo/GO_0050938 GO:0050939 biolink:BiologicalProcess regulation of early stripe melanocyte differentiation Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation. go.json regulation of early stripe melanophore differentiation http://purl.obolibrary.org/obo/GO_0050939 GO:0035306 biolink:BiologicalProcess positive regulation of dephosphorylation Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. go.json activation of dephosphorylation|stimulation of dephosphorylation|up regulation of dephosphorylation|up-regulation of dephosphorylation|upregulation of dephosphorylation http://purl.obolibrary.org/obo/GO_0035306 GO:0035307 biolink:BiologicalProcess positive regulation of protein dephosphorylation Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. go.json activation of protein amino acid dephosphorylation|positive regulation of protein amino acid dephosphorylation|stimulation of protein amino acid dephosphorylation|up regulation of protein amino acid dephosphorylation|up-regulation of protein amino acid dephosphorylation|upregulation of protein amino acid dephosphorylation http://purl.obolibrary.org/obo/GO_0035307 GO:0035308 biolink:BiologicalProcess negative regulation of protein dephosphorylation Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein. go.json down regulation of protein amino acid dephosphorylation|down-regulation of protein amino acid dephosphorylation|downregulation of protein amino acid dephosphorylation|inhibition of protein amino acid dephosphorylation|negative regulation of protein amino acid dephosphorylation http://purl.obolibrary.org/obo/GO_0035308 GO:0035309 biolink:BiologicalProcess wing and notum subfield formation The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures. go.json http://purl.obolibrary.org/obo/GO_0035309 GO:0035300 biolink:MolecularActivity obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. go.json ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity|IP56K|Ins(1,3,4)P3 5/6-kinase activity|inositol 1,3,4-trisphosphate 5-kinase activity|inositol 1,3,4-trisphosphate 6-kinase activity|inositol trisphosphate 5/6-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity True http://purl.obolibrary.org/obo/GO_0035300 GO:0035301 biolink:CellularComponent Hedgehog signaling complex A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila). go.json HSC|Hedgehog signalling complex http://purl.obolibrary.org/obo/GO_0035301 GO:0035302 biolink:MolecularActivity ecdysteroid 25-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods. go.json http://purl.obolibrary.org/obo/GO_0035302 GO:0035303 biolink:BiologicalProcess regulation of dephosphorylation Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. go.json http://purl.obolibrary.org/obo/GO_0035303 GO:0035304 biolink:BiologicalProcess regulation of protein dephosphorylation Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein. go.json regulation of protein amino acid dephosphorylation http://purl.obolibrary.org/obo/GO_0035304 GO:0035305 biolink:BiologicalProcess negative regulation of dephosphorylation Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. go.json down regulation of dephosphorylation|down-regulation of dephosphorylation|downregulation of dephosphorylation|inhibition of dephosphorylation http://purl.obolibrary.org/obo/GO_0035305 GO:0001994 biolink:BiologicalProcess norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure. go.json noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure|norepinephrine-epinephrine vasoconstriction during blood pressure control|norepinephrine-epinephrine vasoconstriction during blood pressure regulation|norepinephrine-epinephrine vasoconstriction during control of blood pressure http://purl.obolibrary.org/obo/GO_0001994 GO:0001995 biolink:BiologicalProcess norepinephrine-epinephrine catabolic process in blood stream The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream. go.json noradrenaline-adrenalin catabolic process in blood stream http://purl.obolibrary.org/obo/GO_0001995 GO:0001996 biolink:BiologicalProcess positive regulation of heart rate by epinephrine-norepinephrine The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction. go.json activation of heart contraction rate by epinephrine-norepinephrine|increased chronotropy by epinephrine-norepinephrine|positive control of heart contraction rate by epinephrine-norepinephrine|positive regulation of cardiac contraction rate by epinephrine-norepinephrine|positive regulation of heart contraction rate by adrenaline-noradrenaline|positive regulation of heart contraction rate by epinephrine-norepinephrine|stimulation of heart contraction rate by epinephrine-norepinephrine|up regulation of heart contraction rate by epinephrine-norepinephrine|up-regulation of heart contraction rate by epinephrine-norepinephrine|upregulation of heart contraction rate by epinephrine-norepinephrine http://purl.obolibrary.org/obo/GO_0001996 GO:0001997 biolink:BiologicalProcess positive regulation of the force of heart contraction by epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings. go.json increased force of heart contraction by adrenaline-noradrenaline|increased force of heart contraction by epinephrine-norepinephrine|increased inotropy by epinephrine-norepinephrine|increased strength of cardiac contraction by epinephrine-norepinephrine|positive regulation of heart contraction by adrenaline-noradrenaline|positive regulation of heart contraction by epinephrine-norepinephrine http://purl.obolibrary.org/obo/GO_0001997 GO:0001990 biolink:BiologicalProcess regulation of systemic arterial blood pressure by hormone The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. go.json blood pressure regulation by hormone|hormonal control of blood pressure|hormonal regulation of blood pressure http://purl.obolibrary.org/obo/GO_0001990 GO:0001991 biolink:BiologicalProcess regulation of systemic arterial blood pressure by circulatory renin-angiotensin The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. go.json circulatory renin-angiotensin blood pressure regulation|circulatory renin-angiotensin control of blood pressure|circulatory renin-angiotensin regulation of blood pressure|control of blood pressure by circulatory renin-angiotensin|renin-angiotensin blood pressure control http://purl.obolibrary.org/obo/GO_0001991 GO:0001992 biolink:BiologicalProcess regulation of systemic arterial blood pressure by vasopressin The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. go.json blood pressure regulation by vasopressin|vasopressin control of blood pressure http://purl.obolibrary.org/obo/GO_0001992 GO:0001993 biolink:BiologicalProcess regulation of systemic arterial blood pressure by norepinephrine-epinephrine The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system. go.json noradrenaline-adrenaline regulation of blood pressure|norepinephrine-epinephrine blood pressure control|norepinephrine-epinephrine blood pressure regulation http://purl.obolibrary.org/obo/GO_0001993 GO:0001998 biolink:BiologicalProcess angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream. go.json angiotensin mediated vasoconstriction during blood pressure control|angiotensin mediated vasoconstriction during blood pressure regulation|angiotensin mediated vasoconstriction during control of blood pressure|angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0001998 GO:0001999 biolink:BiologicalProcess renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure The physiological response of the kidneys to a decrease in blood flow. go.json renal response to blood flow during renin-angiotensin control of blood pressure http://purl.obolibrary.org/obo/GO_0001999 GO:0001972 biolink:MolecularActivity retinoic acid binding Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. go.json http://purl.obolibrary.org/obo/GO_0001972 GO:0001973 biolink:BiologicalProcess G protein-coupled adenosine receptor signaling pathway The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. go.json P1 receptor signaling pathway|adenosine receptor signaling pathway|adenosine receptor signaling pathway, G-protein coupled|adenosine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0001973 GO:0001974 biolink:BiologicalProcess blood vessel remodeling The reorganization or renovation of existing blood vessels. go.json blood vessel remodelling http://purl.obolibrary.org/obo/GO_0001974 GO:0001975 biolink:BiologicalProcess response to amphetamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. go.json http://purl.obolibrary.org/obo/GO_0001975 GO:0001970 biolink:BiologicalProcess positive regulation of activation of membrane attack complex Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. go.json activation of activation of membrane attack complex|positive regulation of MAC assembly|positive regulation of MAC formation|positive regulation of activation of MAC|positive regulation of activation of TCC|positive regulation of activation of terminal complement complex|positive regulation of activation of the terminal complement cascade|positive regulation of membrane attack complex assembly|positive regulation of membrane attack complex formation|stimulation of activation of membrane attack complex|up regulation of activation of membrane attack complex|up-regulation of activation of membrane attack complex|upregulation of activation of membrane attack complex http://purl.obolibrary.org/obo/GO_0001970 GO:0001971 biolink:BiologicalProcess negative regulation of activation of membrane attack complex Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. go.json down regulation of activation of membrane attack complex|down-regulation of activation of membrane attack complex|downregulation of activation of membrane attack complex|inhibition of activation of membrane attack complex|negative regulation of MAC assembly|negative regulation of MAC formation|negative regulation of activation of MAC|negative regulation of activation of TCC|negative regulation of activation of terminal complement complex|negative regulation of activation of the terminal complement cascade|negative regulation of membrane attack complex assembly|negative regulation of membrane attack complex formation http://purl.obolibrary.org/obo/GO_0001971 GO:0001976 biolink:BiologicalProcess nervous system process involved in regulation of systemic arterial blood pressure The regulation of blood pressure mediated by detection of stimuli and a neurological response. go.json blood pressure regulation by neurological process|fast control of arterial pressure|neurological process involved in regulation of systemic arterial blood pressure|neurological system process involved in regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0001976 GO:0001977 biolink:BiologicalProcess renal system process involved in regulation of blood volume A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. go.json renal blood volume control of blood pressure|renal regulation of blood volume http://purl.obolibrary.org/obo/GO_0001977 gocheck_do_not_annotate GO:0001978 biolink:BiologicalProcess regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. go.json baroreceptor feedback control of blood pressure|baroreceptor pressure buffer system|carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0001978 GO:0001979 biolink:BiologicalProcess regulation of systemic arterial blood pressure by chemoreceptor signaling The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. go.json chemoreceptor control of blood pressure|chemoreceptor regulation of systemic arterial blood pressure|regulation of systemic arterial blood pressure by chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0001979 GO:0001983 biolink:BiologicalProcess baroreceptor response to increased systemic arterial blood pressure The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels. go.json http://purl.obolibrary.org/obo/GO_0001983 GO:0001984 biolink:BiologicalProcess artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure. go.json vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0001984 GO:0001985 biolink:BiologicalProcess negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure. go.json down regulation of heart contraction rate in baroreceptor response to increased blood pressure|down-regulation of heart contraction rate in baroreceptor response to increased blood pressure|downregulation of heart contraction rate in baroreceptor response to increased blood pressure|inhibition of heart contraction rate in baroreceptor response to increased blood pressure|negative control of heart contraction rate in baroreceptor response to increased blood pressure|negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure|negative regulation of heart contraction rate in baroreceptor response to increased blood pressure http://purl.obolibrary.org/obo/GO_0001985 GO:0001986 biolink:BiologicalProcess negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure. go.json decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure|decreased strength of cardiac contraction during baroreceptor response to increased blood pressure http://purl.obolibrary.org/obo/GO_0001986 GO:0001980 biolink:BiologicalProcess regulation of systemic arterial blood pressure by ischemic conditions The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system. go.json CNS ischemic response|ischemic control of blood pressure|ischemic regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0001980 GO:0001981 biolink:BiologicalProcess baroreceptor detection of arterial stretch The series of events by which the change in diameter of an artery is detected and converted to a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0001981 GO:0001982 biolink:BiologicalProcess baroreceptor response to decreased systemic arterial blood pressure The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels. go.json http://purl.obolibrary.org/obo/GO_0001982 GO:0001987 biolink:BiologicalProcess vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure. go.json http://purl.obolibrary.org/obo/GO_0001987 GO:0001988 biolink:BiologicalProcess positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure. go.json activation of heart contraction rate in baroreceptor response to decreased blood pressure|positive control of heart contraction rate in baroreceptor response to decreased blood pressure|positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure|positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure|stimulation of heart contraction rate in baroreceptor response to decreased blood pressure|up regulation of heart contraction rate in baroreceptor response to decreased blood pressure|up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure|upregulation of heart contraction rate in baroreceptor response to decreased blood pressure http://purl.obolibrary.org/obo/GO_0001988 GO:0001989 biolink:BiologicalProcess positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure. go.json increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure|increased strength of cardiac contraction during baroreceptor response to decreased blood pressure|positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0001989 GO:0001950 biolink:CellularComponent obsolete plasma membrane enriched fraction OBSOLETE. The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes. go.json PME fraction|plasma membrane enriched fraction True http://purl.obolibrary.org/obo/GO_0001950 GO:0001951 biolink:BiologicalProcess intestinal D-glucose absorption Uptake of D-glucose into the blood by absorption from the small intestine. go.json http://purl.obolibrary.org/obo/GO_0001951 GO:0001952 biolink:BiologicalProcess regulation of cell-matrix adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0001952 GO:0001953 biolink:BiologicalProcess negative regulation of cell-matrix adhesion Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. go.json down regulation of cell-matrix adhesion|down-regulation of cell-matrix adhesion|downregulation of cell-matrix adhesion|inhibition of cell-matrix adhesion http://purl.obolibrary.org/obo/GO_0001953 GO:0001958 biolink:BiologicalProcess endochondral ossification Replacement ossification wherein bone tissue replaces cartilage. Wikipedia:Endochondral_ossification go.json http://purl.obolibrary.org/obo/GO_0001958 GO:0001959 biolink:BiologicalProcess regulation of cytokine-mediated signaling pathway Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway. go.json regulation of cytokine and chemokine mediated signaling pathway|regulation of cytokine mediated signaling pathway|regulation of cytokine mediated signalling pathway http://purl.obolibrary.org/obo/GO_0001959 GO:0001954 biolink:BiologicalProcess positive regulation of cell-matrix adhesion Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. go.json activation of cell-matrix adhesion|stimulation of cell-matrix adhesion|up regulation of cell-matrix adhesion|up-regulation of cell-matrix adhesion|upregulation of cell-matrix adhesion http://purl.obolibrary.org/obo/GO_0001954 GO:0001955 biolink:BiologicalProcess blood vessel maturation A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0001955 GO:0001956 biolink:BiologicalProcess positive regulation of neurotransmitter secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. go.json activation of neurotransmitter secretion|stimulation of neurotransmitter secretion|up regulation of neurotransmitter secretion|up-regulation of neurotransmitter secretion|upregulation of neurotransmitter secretion http://purl.obolibrary.org/obo/GO_0001956 GO:0001957 biolink:BiologicalProcess intramembranous ossification Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. Wikipedia:Intramembranous_ossification go.json dermal ossification|intramembranous bone ossification http://purl.obolibrary.org/obo/GO_0001957 GO:0001961 biolink:BiologicalProcess positive regulation of cytokine-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway. go.json activation of cytokine mediated signaling pathway|positive regulation of cytokine and chemokine mediated signaling pathway|positive regulation of cytokine mediated signaling pathway|positive regulation of cytokine mediated signalling pathway|stimulation of cytokine mediated signaling pathway|up regulation of cytokine mediated signaling pathway|up-regulation of cytokine mediated signaling pathway|upregulation of cytokine mediated signaling pathway http://purl.obolibrary.org/obo/GO_0001961 GO:0001962 biolink:MolecularActivity alpha-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage. go.json isoglobotriaosylceramide synthase http://purl.obolibrary.org/obo/GO_0001962 GO:0001963 biolink:BiologicalProcess synaptic transmission, dopaminergic The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json dopaminergic synaptic transmission http://purl.obolibrary.org/obo/GO_0001963 GO:0001964 biolink:BiologicalProcess startle response An action or movement due to the application of a sudden unexpected stimulus. Wikipedia:Startle_reaction go.json http://purl.obolibrary.org/obo/GO_0001964 GO:0001960 biolink:BiologicalProcess negative regulation of cytokine-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. go.json down regulation of cytokine mediated signaling pathway|down-regulation of cytokine mediated signaling pathway|downregulation of cytokine mediated signaling pathway|inhibition of cytokine mediated signaling pathway|negative regulation of cytokine and chemokine mediated signaling pathway|negative regulation of cytokine mediated signaling pathway|negative regulation of cytokine mediated signalling pathway http://purl.obolibrary.org/obo/GO_0001960 GO:0001969 biolink:BiologicalProcess regulation of activation of membrane attack complex Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. go.json regulation of MAC assembly|regulation of MAC formation|regulation of activation of MAC|regulation of activation of TCC|regulation of activation of terminal complement complex|regulation of activation of the terminal complement cascade|regulation of membrane attack complex assembly|regulation of membrane attack complex formation http://purl.obolibrary.org/obo/GO_0001969 GO:0001965 biolink:MolecularActivity G-protein alpha-subunit binding Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. go.json G-alpha protein subunit binding http://purl.obolibrary.org/obo/GO_0001965 GO:0001966 biolink:BiologicalProcess thigmotaxis The directed movement of an animal in response to touch. go.json stereotaxis|taxis in response to mechanical stimulus|taxis in response to touch stimulus http://purl.obolibrary.org/obo/GO_0001966 GO:0001967 biolink:BiologicalProcess suckling behavior Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. go.json nursing behavior http://purl.obolibrary.org/obo/GO_0001967 GO:0001968 biolink:MolecularActivity fibronectin binding Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. go.json http://purl.obolibrary.org/obo/GO_0001968 goslim_chembl GO:0098840 biolink:BiologicalProcess protein transport along microtubule The directed movement of a protein along a microtubule, mediated by motor proteins. go.json microtubule-based protein transport http://purl.obolibrary.org/obo/GO_0098840 GO:0098841 biolink:BiologicalProcess protein localization to cell division site after cytokinesis A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0098841 GO:1902658 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902658 GO:1902659 biolink:BiologicalProcess regulation of glucose mediated signaling pathway Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway. go.json regulation of glucose mediated signalling http://purl.obolibrary.org/obo/GO_1902659 GO:1902656 biolink:BiologicalProcess calcium ion import into cytosol The directed movement of calcium ion into a cytosol. go.json calcium import into cytosol http://purl.obolibrary.org/obo/GO_1902656 GO:1902657 biolink:BiologicalProcess protein localization to prospore membrane A process in which a protein is transported to, or maintained in, a location within a prospore membrane. go.json establishment of protein localisation in prospore membrane|establishment of protein localisation to prospore membrane|establishment of protein localization in prospore membrane|establishment of protein localization to prospore membrane|protein localisation in prospore membrane|protein localisation to prospore membrane|protein localization in prospore membrane|protein targeting to FSM|protein targeting to ascospore-type prospore membrane|protein targeting to forespore membrane|protein targeting to prospore membrane|protein-prospore membrane targeting http://purl.obolibrary.org/obo/GO_1902657 GO:1902654 biolink:BiologicalProcess aromatic primary alcohol metabolic process The chemical reactions and pathways involving aromatic primary alcohol. go.json aromatic primary alcohol metabolism http://purl.obolibrary.org/obo/GO_1902654 GO:1902655 biolink:BiologicalProcess aromatic primary alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic primary alcohol. go.json aromatic primary alcohol anabolism|aromatic primary alcohol biosynthesis|aromatic primary alcohol formation|aromatic primary alcohol synthesis http://purl.obolibrary.org/obo/GO_1902655 GO:1902652 biolink:BiologicalProcess secondary alcohol metabolic process The chemical reactions and pathways involving secondary alcohol. go.json secondary alcohol metabolism http://purl.obolibrary.org/obo/GO_1902652 GO:1902653 biolink:BiologicalProcess secondary alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of secondary alcohol. go.json secondary alcohol anabolism|secondary alcohol biosynthesis|secondary alcohol formation|secondary alcohol synthesis http://purl.obolibrary.org/obo/GO_1902653 GO:1902650 biolink:BiologicalProcess obsolete negative regulation of histone H2A-H2B dimer displacement OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A-H2B dimer displacement. go.json down regulation of histone H2A-H2B dimer displacement|down-regulation of histone H2A-H2B dimer displacement|downregulation of histone H2A-H2B dimer displacement|inhibition of histone H2A-H2B dimer displacement True http://purl.obolibrary.org/obo/GO_1902650 GO:0060230 biolink:MolecularActivity lipoprotein lipase activator activity Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein. go.json http://purl.obolibrary.org/obo/GO_0060230 GO:1902651 biolink:BiologicalProcess obsolete positive regulation of histone H2A-H2B dimer displacement OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2A-H2B dimer displacement. go.json activation of histone H2A-H2B dimer displacement|up regulation of histone H2A-H2B dimer displacement|up-regulation of histone H2A-H2B dimer displacement|upregulation of histone H2A-H2B dimer displacement True http://purl.obolibrary.org/obo/GO_1902651 GO:0060231 biolink:BiologicalProcess mesenchymal to epithelial transition A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. go.json epithelial cell differentiation from mesenchymal cell|mesenchymal-epithelial transition http://purl.obolibrary.org/obo/GO_0060231 GO:0060232 biolink:BiologicalProcess delamination The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0060232 GO:0035265 biolink:BiologicalProcess organ growth The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. go.json http://purl.obolibrary.org/obo/GO_0035265 GO:1902660 biolink:BiologicalProcess negative regulation of glucose mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway. go.json down regulation of glucose mediated signaling pathway|down regulation of glucose mediated signalling|down-regulation of glucose mediated signaling pathway|down-regulation of glucose mediated signalling|downregulation of glucose mediated signaling pathway|downregulation of glucose mediated signalling|inhibition of glucose mediated signaling pathway|inhibition of glucose mediated signalling|negative regulation of glucose mediated signalling http://purl.obolibrary.org/obo/GO_1902660 GO:0060233 biolink:BiologicalProcess oenocyte delamination The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0060233 GO:0035266 biolink:BiologicalProcess meristem growth The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. go.json http://purl.obolibrary.org/obo/GO_0035266 GO:0035267 biolink:CellularComponent NuA4 histone acetyltransferase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). go.json TIP60 histone acetylase complex|TIP60 histone acetyltransferase complex http://purl.obolibrary.org/obo/GO_0035267 GO:0060234 biolink:BiologicalProcess neuroblast delamination The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet. go.json http://purl.obolibrary.org/obo/GO_0060234 GO:0035268 biolink:BiologicalProcess protein mannosylation The addition of a mannose residue to a protein acceptor molecule. go.json protein amino acid mannosylation http://purl.obolibrary.org/obo/GO_0035268 GO:0060235 biolink:BiologicalProcess lens induction in camera-type eye Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens. go.json http://purl.obolibrary.org/obo/GO_0060235 GO:0060236 biolink:BiologicalProcess regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. go.json regulation of mitotic spindle organisation|regulation of mitotic spindle organization and biogenesis http://purl.obolibrary.org/obo/GO_0060236 GO:0035269 biolink:BiologicalProcess protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. go.json protein amino acid O-linked mannosylation http://purl.obolibrary.org/obo/GO_0035269 GO:0060237 biolink:BiologicalProcess regulation of fungal-type cell wall organization Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall. go.json regulation of fungal-type cell wall organisation|regulation of fungal-type cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0060237 GO:0060238 biolink:BiologicalProcess regulation of signal transduction involved in conjugation with cellular fusion Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0060238 GO:0060239 biolink:BiologicalProcess positive regulation of signal transduction involved in conjugation with cellular fusion Any process that increases the rate, frequency or extent of signal transduction involved in conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0060239 GO:0098848 biolink:MolecularActivity alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane. EC:4.7.1.1|RHEA:34707 go.json alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming) http://purl.obolibrary.org/obo/GO_0098848 GO:0098849 biolink:BiologicalProcess cellular detoxification of cadmium ion Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. go.json http://purl.obolibrary.org/obo/GO_0098849 GO:0098846 biolink:CellularComponent podocyte foot A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms. Wikipedia:Podocyte go.json pedicel|podocyte foot process|secondary podocyte projection http://purl.obolibrary.org/obo/GO_0098846 GO:0098847 biolink:MolecularActivity sequence-specific single stranded DNA binding Binding to single-stranded DNA of a specific nucleotide composition. go.json http://purl.obolibrary.org/obo/GO_0098847 GO:0035260 biolink:BiologicalProcess internal genitalia morphogenesis The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. go.json http://purl.obolibrary.org/obo/GO_0035260 GO:0035261 biolink:BiologicalProcess external genitalia morphogenesis The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. go.json http://purl.obolibrary.org/obo/GO_0035261 GO:0098844 biolink:CellularComponent postsynaptic endocytic zone membrane The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta. go.json http://purl.obolibrary.org/obo/GO_0098844 goslim_synapse GO:0035262 biolink:BiologicalProcess gonad morphogenesis The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. go.json http://purl.obolibrary.org/obo/GO_0035262 GO:0098845 biolink:CellularComponent postsynaptic endosome An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0098845 goslim_synapse GO:0035263 biolink:BiologicalProcess genital disc sexually dimorphic development The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed. go.json http://purl.obolibrary.org/obo/GO_0035263 GO:0098842 biolink:CellularComponent postsynaptic early endosome An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling. go.json http://purl.obolibrary.org/obo/GO_0098842 goslim_synapse GO:0035264 biolink:BiologicalProcess multicellular organism growth The increase in size or mass of an entire multicellular organism, as opposed to cell growth. go.json body growth http://purl.obolibrary.org/obo/GO_0035264 GO:0098843 biolink:CellularComponent postsynaptic endocytic zone A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. go.json http://purl.obolibrary.org/obo/GO_0098843 goslim_synapse GO:0098851 biolink:MolecularActivity double-stranded miRNA binding Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures. go.json miRNA duplex binding http://purl.obolibrary.org/obo/GO_0098851 GO:0098852 biolink:CellularComponent lytic vacuole membrane The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. go.json http://purl.obolibrary.org/obo/GO_0098852 GO:0098850 biolink:CellularComponent extrinsic component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098850 goslim_synapse GO:1902669 biolink:BiologicalProcess positive regulation of axon guidance Any process that activates or increases the frequency, rate or extent of axon guidance. go.json activation of axon chemotaxis|activation of axon growth cone guidance|activation of axon guidance|activation of axon pathfinding|positive regulation of axon chemotaxis|positive regulation of axon growth cone guidance|positive regulation of axon pathfinding|up regulation of axon chemotaxis|up regulation of axon growth cone guidance|up regulation of axon guidance|up regulation of axon pathfinding|up-regulation of axon chemotaxis|up-regulation of axon growth cone guidance|up-regulation of axon guidance|up-regulation of axon pathfinding|upregulation of axon chemotaxis|upregulation of axon growth cone guidance|upregulation of axon guidance|upregulation of axon pathfinding http://purl.obolibrary.org/obo/GO_1902669 GO:2001204 biolink:BiologicalProcess regulation of osteoclast development Any process that modulates the frequency, rate or extent of osteoclast development. go.json regulation of osteoclast cell development http://purl.obolibrary.org/obo/GO_2001204 GO:1902667 biolink:BiologicalProcess regulation of axon guidance Any process that modulates the frequency, rate or extent of axon guidance. go.json regulation of axon chemotaxis|regulation of axon growth cone guidance|regulation of axon pathfinding http://purl.obolibrary.org/obo/GO_1902667 GO:1902668 biolink:BiologicalProcess negative regulation of axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. go.json down regulation of axon chemotaxis|down regulation of axon growth cone guidance|down regulation of axon guidance|down regulation of axon pathfinding|down-regulation of axon chemotaxis|down-regulation of axon growth cone guidance|down-regulation of axon guidance|down-regulation of axon pathfinding|downregulation of axon chemotaxis|downregulation of axon growth cone guidance|downregulation of axon guidance|downregulation of axon pathfinding|inhibition of axon chemotaxis|inhibition of axon growth cone guidance|inhibition of axon guidance|inhibition of axon pathfinding|negative regulation of axon chemotaxis|negative regulation of axon growth cone guidance|negative regulation of axon pathfinding http://purl.obolibrary.org/obo/GO_1902668 GO:2001205 biolink:BiologicalProcess negative regulation of osteoclast development Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. go.json negative regulation of osteoclast cell development http://purl.obolibrary.org/obo/GO_2001205 GO:1902665 biolink:BiologicalProcess response to isobutanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus. go.json process resulting in tolerance to isobutanol|response to 2-methylpropan-1-ol http://purl.obolibrary.org/obo/GO_1902665 GO:2001206 biolink:BiologicalProcess positive regulation of osteoclast development Any process that activates or increases the frequency, rate or extent of osteoclast development. go.json positive regulation of osteoclast cell development http://purl.obolibrary.org/obo/GO_2001206 GO:1902666 biolink:BiologicalProcess obsolete protein localization to Mmi1 nuclear focus complex OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a Mmi1 nuclear focus complex. go.json protein localisation in Mmi1 nuclear focus complex|protein localisation to Mmi1 nuclear focus complex|protein localization in Mmi1 nuclear focus complex True http://purl.obolibrary.org/obo/GO_1902666 GO:2001207 biolink:BiologicalProcess regulation of transcription elongation by RNA polymerase I Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. go.json regulation of RNA elongation from Pol I promoter|regulation of transcription elongation from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_2001207 GO:1902663 biolink:BiologicalProcess negative regulation of peptidyl-L-cysteine S-palmitoylation Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation. go.json down regulation of peptidyl-L-cysteine S-palmitoylation|down regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|down regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|down regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|down regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|down regulation of peptidyl-cysteine S-palmitoylation|down-regulation of peptidyl-L-cysteine S-palmitoylation|down-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|down-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|down-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|down-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|down-regulation of peptidyl-cysteine S-palmitoylation|downregulation of peptidyl-L-cysteine S-palmitoylation|downregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|downregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|downregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|downregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|downregulation of peptidyl-cysteine S-palmitoylation|inhibition of peptidyl-L-cysteine S-palmitoylation|inhibition of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|inhibition of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|inhibition of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|inhibition of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|inhibition of peptidyl-cysteine S-palmitoylation|negative regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|negative regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|negative regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|negative regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|negative regulation of peptidyl-cysteine S-palmitoylation http://purl.obolibrary.org/obo/GO_1902663 GO:2001208 biolink:BiologicalProcess negative regulation of transcription elongation by RNA polymerase I Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I. go.json negative regulation of RNA elongation from Pol I promoter|negative regulation of transcription elongation from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_2001208 GO:1902664 biolink:BiologicalProcess positive regulation of peptidyl-L-cysteine S-palmitoylation Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation. go.json activation of peptidyl-L-cysteine S-palmitoylation|activation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|activation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|activation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|activation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|activation of peptidyl-cysteine S-palmitoylation|positive regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|positive regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|positive regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|positive regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|positive regulation of peptidyl-cysteine S-palmitoylation|up regulation of peptidyl-L-cysteine S-palmitoylation|up regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|up regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|up regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|up regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|up regulation of peptidyl-cysteine S-palmitoylation|up-regulation of peptidyl-L-cysteine S-palmitoylation|up-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|up-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|up-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|up-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|up-regulation of peptidyl-cysteine S-palmitoylation|upregulation of peptidyl-L-cysteine S-palmitoylation|upregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|upregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|upregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|upregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|upregulation of peptidyl-cysteine S-palmitoylation http://purl.obolibrary.org/obo/GO_1902664 GO:2001209 biolink:BiologicalProcess positive regulation of transcription elongation by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. go.json positive regulation of RNA elongation from Pol I promoter|positive regulation of transcription elongation from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_2001209 GO:1902661 biolink:BiologicalProcess positive regulation of glucose mediated signaling pathway Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway. go.json activation of glucose mediated signaling pathway|activation of glucose mediated signalling|positive regulation of glucose mediated signalling|up regulation of glucose mediated signaling pathway|up regulation of glucose mediated signalling|up-regulation of glucose mediated signaling pathway|up-regulation of glucose mediated signalling|upregulation of glucose mediated signaling pathway|upregulation of glucose mediated signalling http://purl.obolibrary.org/obo/GO_1902661 GO:1902662 biolink:BiologicalProcess regulation of peptidyl-L-cysteine S-palmitoylation Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation. go.json regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|regulation of peptidyl-cysteine S-palmitoylation http://purl.obolibrary.org/obo/GO_1902662 GO:0060220 biolink:BiologicalProcess camera-type eye photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0060220 GO:1902670 biolink:MolecularActivity carbon dioxide binding Binding to carbon dioxide. go.json CO2 binding http://purl.obolibrary.org/obo/GO_1902670 GO:0060221 biolink:BiologicalProcess retinal rod cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. go.json http://purl.obolibrary.org/obo/GO_0060221 GO:0035254 biolink:MolecularActivity glutamate receptor binding Binding to a glutamate receptor. go.json http://purl.obolibrary.org/obo/GO_0035254 goslim_chembl GO:0060222 biolink:BiologicalProcess regulation of retinal cone cell fate commitment Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. go.json http://purl.obolibrary.org/obo/GO_0060222 GO:1902671 biolink:CellularComponent left anterior basal body Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of left anterior cilium|cilial basal body of left anterior flagellum|ciliary basal body of left anterior cilium|ciliary basal body of left anterior flagellum|cilium basal body of left anterior cilium|cilium basal body of left anterior flagellum|left anterior flagellum ciliary basal body|microtubule basal body of left anterior cilium|microtubule basal body of left anterior flagellum http://purl.obolibrary.org/obo/GO_1902671 GO:0035255 biolink:MolecularActivity ionotropic glutamate receptor binding Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. go.json http://purl.obolibrary.org/obo/GO_0035255 GO:0035256 biolink:MolecularActivity G protein-coupled glutamate receptor binding Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). go.json G-protein coupled glutamate receptor binding|metabotropic glutamate receptor binding http://purl.obolibrary.org/obo/GO_0035256 GO:0060223 biolink:BiologicalProcess retinal rod cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0060223 GO:0060224 biolink:BiologicalProcess regulation of retinal rod cell fate commitment Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0060224 GO:0035257 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035257 GO:2001200 biolink:BiologicalProcess positive regulation of dendritic cell differentiation Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. go.json http://purl.obolibrary.org/obo/GO_2001200 GO:0060225 biolink:BiologicalProcess positive regulation of retinal rod cell fate commitment Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0060225 GO:0035258 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035258 GO:2001201 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001201 GO:0060226 biolink:BiologicalProcess negative regulation of retinal cone cell fate commitment Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. go.json http://purl.obolibrary.org/obo/GO_0060226 GO:0035259 biolink:MolecularActivity nuclear glucocorticoid receptor binding Binding to a nuclear glucocorticoid receptor. go.json glucocorticoid receptor binding http://purl.obolibrary.org/obo/GO_0035259 GO:0060227 biolink:BiologicalProcess Notch signaling pathway involved in camera-type eye photoreceptor fate commitment The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate. go.json Notch signalling pathway involved in camera-type eye photoreceptor fate commitment http://purl.obolibrary.org/obo/GO_0060227 GO:2001202 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001202 GO:0060228 biolink:MolecularActivity phosphatidylcholine-sterol O-acyltransferase activator activity Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. go.json LCAT activator activity http://purl.obolibrary.org/obo/GO_0060228 GO:2001203 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001203 GO:0060229 biolink:MolecularActivity lipase activator activity Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. go.json http://purl.obolibrary.org/obo/GO_0060229 GO:0098859 biolink:CellularComponent actin filament bundle of actin-based cell projection A bundle of cross-linked actin filaments that is part of an actin-based cell protrusion, in which filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which stabilizes the filaments. go.json http://purl.obolibrary.org/obo/GO_0098859 GO:0098857 biolink:CellularComponent membrane microdomain A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. go.json http://purl.obolibrary.org/obo/GO_0098857 GO:0098858 biolink:CellularComponent actin-based cell projection A cell projection supported by an assembly of actin filaments, and which lacks microtubules. go.json http://purl.obolibrary.org/obo/GO_0098858 GO:0098855 biolink:CellularComponent HCN channel complex A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart. go.json HCN1 channel complex|HCN2 channel complex|HCN3 channel complex|HCN4 channel complex|K/Na hyperpolarization-activated channel 3 complex|K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex|K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex|K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex|K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex|potassium/sodium hyperpolarization-activated channel 3 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex http://purl.obolibrary.org/obo/GO_0098855 GO:0035250 biolink:MolecularActivity UDP-galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0035250 GO:0098856 biolink:BiologicalProcess intestinal lipid absorption Any process in which lipids are taken up from the contents of the intestine. go.json http://purl.obolibrary.org/obo/GO_0098856 GO:0035251 biolink:MolecularActivity UDP-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. Reactome:R-HSA-1912353 go.json http://purl.obolibrary.org/obo/GO_0035251 GO:0098853 biolink:CellularComponent endoplasmic reticulum-vacuole membrane contact site A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes. go.json ER-vacuole membrane contact site http://purl.obolibrary.org/obo/GO_0098853 GO:0035252 biolink:MolecularActivity UDP-xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. Reactome:R-HSA-5617138|Reactome:R-HSA-6785668|Reactome:R-HSA-9638090 go.json http://purl.obolibrary.org/obo/GO_0035252 GO:0035253 biolink:CellularComponent ciliary rootlet A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. go.json cilial rootlet|cilium rootlet http://purl.obolibrary.org/obo/GO_0035253 GO:0098854 biolink:CellularComponent podocyte primary projection A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot. go.json glomerular visceral epithelial cell primary projection|podocyte major process|primary podocyte process http://purl.obolibrary.org/obo/GO_0098854 GO:1902678 biolink:CellularComponent right caudal basal body Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of right caudal cilium|cilial basal body of right caudal flagellum|ciliary basal body of right caudal cilium|ciliary basal body of right caudal flagellum|cilium basal body of right caudal cilium|cilium basal body of right caudal flagellum|microtubule basal body of right caudal cilium|microtubule basal body of right caudal flagellum|right caudal flagellum ciliary basal body http://purl.obolibrary.org/obo/GO_1902678 GO:2001215 biolink:BiologicalProcess obsolete regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity OBSOLETE. Any process that modulates the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity. go.json regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|regulation of HMG-CoA reductase activity True http://purl.obolibrary.org/obo/GO_2001215 GO:1902679 biolink:BiologicalProcess negative regulation of RNA biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. go.json down regulation of RNA anabolism|down regulation of RNA biosynthesis|down regulation of RNA biosynthetic process|down regulation of RNA formation|down regulation of RNA synthesis|down-regulation of RNA anabolism|down-regulation of RNA biosynthesis|down-regulation of RNA biosynthetic process|down-regulation of RNA formation|down-regulation of RNA synthesis|downregulation of RNA anabolism|downregulation of RNA biosynthesis|downregulation of RNA biosynthetic process|downregulation of RNA formation|downregulation of RNA synthesis|inhibition of RNA anabolism|inhibition of RNA biosynthesis|inhibition of RNA biosynthetic process|inhibition of RNA formation|inhibition of RNA synthesis|negative regulation of RNA anabolism|negative regulation of RNA biosynthesis|negative regulation of RNA formation|negative regulation of RNA synthesis http://purl.obolibrary.org/obo/GO_1902679 GO:2001216 biolink:BiologicalProcess obsolete negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity. go.json negative regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|negative regulation of HMG-CoA reductase activity True http://purl.obolibrary.org/obo/GO_2001216 GO:1902676 biolink:CellularComponent right ventral basal body Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of right ventral cilium|cilial basal body of right ventral flagellum|ciliary basal body of right ventral cilium|ciliary basal body of right ventral flagellum|cilium basal body of right ventral cilium|cilium basal body of right ventral flagellum|microtubule basal body of right ventral cilium|microtubule basal body of right ventral flagellum|right ventral flagellum ciliary basal body http://purl.obolibrary.org/obo/GO_1902676 GO:2001217 biolink:BiologicalProcess obsolete regulation of S/G2 transition of mitotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of S/G2 transition of mitotic cell cycle. go.json regulation of S/G2 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2001217 GO:2001218 biolink:BiologicalProcess obsolete negative regulation of S/G2 transition of mitotic cell cycle OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of S/G2 transition of mitotic cell cycle. go.json negative regulation of S/G2 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2001218 GO:1902677 biolink:CellularComponent left caudal basal body Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of left caudal cilium|cilial basal body of left caudal flagellum|ciliary basal body of left caudal cilium|ciliary basal body of left caudal flagellum|cilium basal body of left caudal cilium|cilium basal body of left caudal flagellum|left caudal flagellum ciliary basal body|microtubule basal body of left caudal cilium|microtubule basal body of left caudal flagellum http://purl.obolibrary.org/obo/GO_1902677 GO:1902674 biolink:CellularComponent right posteriolateral basal body Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of right posteriolateral cilium|cilial basal body of right posteriolateral flagellum|cilial basal body of right posterolateral cilium|cilial basal body of right posterolateral flagellum|ciliary basal body of right posteriolateral cilium|ciliary basal body of right posteriolateral flagellum|ciliary basal body of right posterolateral cilium|ciliary basal body of right posterolateral flagellum|cilium basal body of right posteriolateral cilium|cilium basal body of right posteriolateral flagellum|cilium basal body of right posterolateral cilium|cilium basal body of right posterolateral flagellum|microtubule basal body of right posteriolateral cilium|microtubule basal body of right posteriolateral flagellum|microtubule basal body of right posterolateral cilium|microtubule basal body of right posterolateral flagellum|right posteriolateral flagellum ciliary basal body http://purl.obolibrary.org/obo/GO_1902674 GO:0060250 biolink:BiologicalProcess germ-line stem-cell niche homeostasis A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion. go.json germ-line stem-cell niche maintenance|maintenance of germ line stem cell niche|maintenance of germ line stem-cell niche|maintenance of germ-line stem cell niche|maintenance of germ-line stem-cell niche http://purl.obolibrary.org/obo/GO_0060250 GO:2001219 biolink:BiologicalProcess obsolete positive regulation of S/G2 transition of mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of S/G2 transition of mitotic cell cycle. go.json positive regulation of S/G2 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2001219 GO:1902675 biolink:CellularComponent left ventral basal body Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of left ventral cilium|cilial basal body of left ventral flagellum|ciliary basal body of left ventral cilium|ciliary basal body of left ventral flagellum|cilium basal body of left ventral cilium|cilium basal body of left ventral flagellum|left ventral flagellum ciliary basal body|microtubule basal body of left ventral cilium|microtubule basal body of left ventral flagellum http://purl.obolibrary.org/obo/GO_1902675 GO:0060251 biolink:BiologicalProcess regulation of glial cell proliferation Any process that modulates the frequency, rate or extent of glial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0060251 GO:1902672 biolink:CellularComponent right anterior basal body Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of right anterior cilium|cilial basal body of right anterior flagellum|ciliary basal body of right anterior cilium|ciliary basal body of right anterior flagellum|cilium basal body of right anterior cilium|cilium basal body of right anterior flagellum|microtubule basal body of right anterior cilium|microtubule basal body of right anterior flagellum|right anterior flagellum ciliary basal body http://purl.obolibrary.org/obo/GO_1902672 GO:0060252 biolink:BiologicalProcess positive regulation of glial cell proliferation Any process that activates or increases the rate or extent of glial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0060252 GO:1902673 biolink:CellularComponent left posteriolateral basal body Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage). go.json cilial basal body of left posteriolateral cilium|cilial basal body of left posteriolateral flagellum|cilial basal body of left posterolateral cilium|cilial basal body of left posterolateral flagellum|ciliary basal body of left posteriolateral cilium|ciliary basal body of left posteriolateral flagellum|ciliary basal body of left posterolateral cilium|ciliary basal body of left posterolateral flagellum|cilium basal body of left posteriolateral cilium|cilium basal body of left posteriolateral flagellum|cilium basal body of left posterolateral cilium|cilium basal body of left posterolateral flagellum|left posteriolateral flagellum ciliary basal body|microtubule basal body of left posteriolateral cilium|microtubule basal body of left posteriolateral flagellum|microtubule basal body of left posterolateral cilium|microtubule basal body of left posterolateral flagellum http://purl.obolibrary.org/obo/GO_1902673 GO:0060253 biolink:BiologicalProcess negative regulation of glial cell proliferation Any process that stops or decreases the rate or extent of glial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0060253 GO:0035243 biolink:MolecularActivity protein-arginine omega-N symmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. EC:2.1.1.320|RESID:AA0067|RESID:AA0069|RHEA:48108|Reactome:R-HSA-6804383 go.json S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)|protein arginine omega-N symmetric methylase activity|protein arginine omega-N symmetric methyltransferase activity|type II PRMT activity|type II protein arginine methyltransferase activity http://purl.obolibrary.org/obo/GO_0035243 GO:0060254 biolink:BiologicalProcess regulation of N-terminal protein palmitoylation Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0060254 GO:1902681 biolink:BiologicalProcess regulation of replication fork arrest at rDNA repeats Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats. go.json regulation of replication fork arrest at ribosomal DNA repeats|regulation of replication fork blocking at rDNA repeats http://purl.obolibrary.org/obo/GO_1902681 GO:0060255 biolink:BiologicalProcess regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json http://purl.obolibrary.org/obo/GO_0060255 GO:1902682 biolink:BiologicalProcess protein localization to pericentric heterochromatin A process in which a protein is transported to, or maintained in the pericentric heterochromatin. go.json protein localisation in centromeric heterochromatin http://purl.obolibrary.org/obo/GO_1902682 GO:0035244 biolink:MolecularActivity protein-arginine C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria. EC:2.1.1.379|RESID:AA0272|RHEA:66028 go.json peptidyl arginine C-methyltransferase activity|peptidyl-arginine C-methylase activity|peptidyl-arginine C-methyltransferase activity|protein-arginine C-methylase activity http://purl.obolibrary.org/obo/GO_0035244 GO:0060256 biolink:BiologicalProcess regulation of flocculation Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms. go.json regulation of flocculation via cell wall protein-carbohydrate interaction http://purl.obolibrary.org/obo/GO_0060256 GO:0035245 biolink:BiologicalProcess obsolete peptidyl-arginine C-methylation OBSOLETE. The addition of a methyl group onto a carbon atom of an arginine residue in a protein. go.json True http://purl.obolibrary.org/obo/GO_0035245 GO:0060257 biolink:BiologicalProcess negative regulation of flocculation Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms. go.json negative regulation of coflocculation http://purl.obolibrary.org/obo/GO_0060257 GO:1902680 biolink:BiologicalProcess positive regulation of RNA biosynthetic process Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. go.json activation of RNA anabolism|activation of RNA biosynthesis|activation of RNA biosynthetic process|activation of RNA formation|activation of RNA synthesis|positive regulation of RNA anabolism|positive regulation of RNA biosynthesis|positive regulation of RNA formation|positive regulation of RNA synthesis|up regulation of RNA anabolism|up regulation of RNA biosynthesis|up regulation of RNA biosynthetic process|up regulation of RNA formation|up regulation of RNA synthesis|up-regulation of RNA anabolism|up-regulation of RNA biosynthesis|up-regulation of RNA biosynthetic process|up-regulation of RNA formation|up-regulation of RNA synthesis|upregulation of RNA anabolism|upregulation of RNA biosynthesis|upregulation of RNA biosynthetic process|upregulation of RNA formation|upregulation of RNA synthesis http://purl.obolibrary.org/obo/GO_1902680 GO:2001210 biolink:BiologicalProcess regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. go.json regulation of Ac-MVA pathway|regulation of acetate-mevalonate pathway|regulation of isopentenyl diphosphate anabolism, mevalonate pathway|regulation of isopentenyl diphosphate formation, mevalonate pathway|regulation of isopentenyl diphosphate synthesis, mevalonate pathway http://purl.obolibrary.org/obo/GO_2001210 GO:0035246 biolink:BiologicalProcess peptidyl-arginine N-methylation The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0035246 gocheck_do_not_annotate GO:2001211 biolink:BiologicalProcess negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. go.json negative regulation of Ac-MVA pathway|negative regulation of acetate-mevalonate pathway|negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway|negative regulation of isopentenyl diphosphate formation, mevalonate pathway|negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway http://purl.obolibrary.org/obo/GO_2001211 GO:0060258 biolink:BiologicalProcess negative regulation of filamentous growth Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0060258 GO:0035247 biolink:BiologicalProcess peptidyl-arginine omega-N-methylation The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein. RESID:AA0067|RESID:AA0068|RESID:AA0069 go.json http://purl.obolibrary.org/obo/GO_0035247 gocheck_do_not_annotate GO:2001212 biolink:BiologicalProcess regulation of vasculogenesis Any process that modulates the frequency, rate or extent of vasculogenesis. go.json regulation of vascular morphogenesis http://purl.obolibrary.org/obo/GO_2001212 GO:0060259 biolink:BiologicalProcess regulation of feeding behavior Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. go.json regulation of feeding behaviour http://purl.obolibrary.org/obo/GO_0060259 GO:0035248 biolink:MolecularActivity alpha-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. go.json alpha-1,4-GalNAc transferase activity http://purl.obolibrary.org/obo/GO_0035248 GO:0035249 biolink:BiologicalProcess synaptic transmission, glutamatergic The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json glutamatergic synaptic transmission http://purl.obolibrary.org/obo/GO_0035249 GO:2001213 biolink:BiologicalProcess negative regulation of vasculogenesis Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. go.json negative regulation of vascular morphogenesis http://purl.obolibrary.org/obo/GO_2001213 GO:0098828 biolink:BiologicalProcess modulation of inhibitory postsynaptic potential Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. go.json regulation of inhibitory postsynaptic potential http://purl.obolibrary.org/obo/GO_0098828 GO:2001214 biolink:BiologicalProcess positive regulation of vasculogenesis Any process that activates or increases the frequency, rate or extent of vasculogenesis. go.json positive regulation of vascular morphogenesis http://purl.obolibrary.org/obo/GO_2001214 GO:0098829 biolink:BiologicalProcess intestinal folate absorption Uptake of folic into the blood by absorption from the small intestine. go.json http://purl.obolibrary.org/obo/GO_0098829 GO:0098826 biolink:CellularComponent endoplasmic reticulum tubular network membrane The membrane of the endoplasmic reticulum tubular network. go.json http://purl.obolibrary.org/obo/GO_0098826 GO:0098827 biolink:CellularComponent endoplasmic reticulum subcompartment A distinct region of the endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0098827 GO:0098824 biolink:BiologicalProcess peptidyl-cysteine sulfation The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine. RESID:AA0171 go.json http://purl.obolibrary.org/obo/GO_0098824 gocheck_do_not_annotate GO:0098825 biolink:BiologicalProcess peptidyl-histidine guanylation The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine. RESID:AA0325 go.json http://purl.obolibrary.org/obo/GO_0098825 gocheck_do_not_annotate GO:0098822 biolink:BiologicalProcess peptidyl-cysteine modification to L-cysteine persulfide The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. RESID:AA0269 go.json http://purl.obolibrary.org/obo/GO_0098822 gocheck_do_not_annotate GO:0098823 biolink:BiologicalProcess peptidyl-cysteine modification to S-amindino-L-cysteine The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine. RESID:AA0335 go.json http://purl.obolibrary.org/obo/GO_0098823 gocheck_do_not_annotate GO:0035240 biolink:MolecularActivity dopamine binding Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. go.json http://purl.obolibrary.org/obo/GO_0035240 GO:0035241 biolink:MolecularActivity protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine. EC:2.1.1.321|MetaCyc:2.1.1.124-RXN|RHEA:48100 go.json S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)|protein arginine omega-N monomethylase activity|type III protein arginine methyltransferase activity http://purl.obolibrary.org/obo/GO_0035241 GO:0098820 biolink:CellularComponent trans-synaptic protein complex A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes. go.json http://purl.obolibrary.org/obo/GO_0098820 goslim_synapse GO:0035242 biolink:MolecularActivity protein-arginine omega-N asymmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. EC:2.1.1.319|RHEA:48096|Reactome:R-HSA-9729283 go.json S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)|protein arginine omega-N asymmetric methylase activity|protein arginine omega-N asymmetric methyltransferase activity|type I PRMT activity|type I protein arginine methyltransferase activity http://purl.obolibrary.org/obo/GO_0035242 GO:0098821 biolink:MolecularActivity BMP receptor activity Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0098821 GO:0098830 biolink:CellularComponent presynaptic endosome An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles. go.json http://purl.obolibrary.org/obo/GO_0098830 goslim_synapse GO:1902689 biolink:BiologicalProcess negative regulation of NAD metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of NAD metabolic process. go.json down regulation of NAD (oxidized) metabolic process|down regulation of NAD (oxidized) metabolism|down regulation of NAD metabolic process|down regulation of NAD metabolism|down regulation of NAD phosphorylation and dephosphorylation|down regulation of nicotinamide adenine dinucleotide metabolic process|down regulation of nicotinamide adenine dinucleotide metabolism|down regulation of oxidized NAD metabolic process|down regulation of oxidized NAD metabolism|down regulation of oxidized nicotinamide adenine dinucleotide metabolic process|down regulation of oxidized nicotinamide adenine dinucleotide metabolism|down-regulation of NAD (oxidized) metabolic process|down-regulation of NAD (oxidized) metabolism|down-regulation of NAD metabolic process|down-regulation of NAD metabolism|down-regulation of NAD phosphorylation and dephosphorylation|down-regulation of nicotinamide adenine dinucleotide metabolic process|down-regulation of nicotinamide adenine dinucleotide metabolism|down-regulation of oxidized NAD metabolic process|down-regulation of oxidized NAD metabolism|down-regulation of oxidized nicotinamide adenine dinucleotide metabolic process|down-regulation of oxidized nicotinamide adenine dinucleotide metabolism|downregulation of NAD (oxidized) metabolic process|downregulation of NAD (oxidized) metabolism|downregulation of NAD metabolic process|downregulation of NAD metabolism|downregulation of NAD phosphorylation and dephosphorylation|downregulation of nicotinamide adenine dinucleotide metabolic process|downregulation of nicotinamide adenine dinucleotide metabolism|downregulation of oxidized NAD metabolic process|downregulation of oxidized NAD metabolism|downregulation of oxidized nicotinamide adenine dinucleotide metabolic process|downregulation of oxidized nicotinamide adenine dinucleotide metabolism|inhibition of NAD (oxidized) metabolic process|inhibition of NAD (oxidized) metabolism|inhibition of NAD metabolic process|inhibition of NAD metabolism|inhibition of NAD phosphorylation and dephosphorylation|inhibition of nicotinamide adenine dinucleotide metabolic process|inhibition of nicotinamide adenine dinucleotide metabolism|inhibition of oxidized NAD metabolic process|inhibition of oxidized NAD metabolism|inhibition of oxidized nicotinamide adenine dinucleotide metabolic process|inhibition of oxidized nicotinamide adenine dinucleotide metabolism|negative regulation of NAD (oxidized) metabolic process|negative regulation of NAD (oxidized) metabolism|negative regulation of NAD metabolism|negative regulation of NAD phosphorylation and dephosphorylation|negative regulation of nicotinamide adenine dinucleotide metabolic process|negative regulation of nicotinamide adenine dinucleotide metabolism|negative regulation of oxidized NAD metabolic process|negative regulation of oxidized NAD metabolism|negative regulation of oxidized nicotinamide adenine dinucleotide metabolic process|negative regulation of oxidized nicotinamide adenine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_1902689 GO:2001226 biolink:BiologicalProcess negative regulation of chloride transport Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport. go.json http://purl.obolibrary.org/obo/GO_2001226 GO:2001227 biolink:MolecularActivity quercitrin binding Binding to quercitrin. go.json http://purl.obolibrary.org/obo/GO_2001227 GO:1902687 biolink:CellularComponent glucosidase complex A protein complex which is capable of glucosidase activity. go.json http://purl.obolibrary.org/obo/GO_1902687 GO:2001228 biolink:BiologicalProcess regulation of response to gamma radiation Any process that modulates the frequency, rate or extent of response to gamma radiation. go.json regulation of response to gamma ray|regulation of response to gamma-ray photon http://purl.obolibrary.org/obo/GO_2001228 GO:2001229 biolink:BiologicalProcess negative regulation of response to gamma radiation Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation. go.json negative regulation of response to gamma ray|negative regulation of response to gamma-ray photon http://purl.obolibrary.org/obo/GO_2001229 GO:1902688 biolink:BiologicalProcess regulation of NAD metabolic process Any process that modulates the frequency, rate or extent of NAD metabolic process. go.json regulation of NAD (oxidized) metabolic process|regulation of NAD (oxidized) metabolism|regulation of NAD metabolism|regulation of NAD phosphorylation and dephosphorylation|regulation of nicotinamide adenine dinucleotide metabolic process|regulation of nicotinamide adenine dinucleotide metabolism|regulation of oxidized NAD metabolic process|regulation of oxidized NAD metabolism|regulation of oxidized nicotinamide adenine dinucleotide metabolic process|regulation of oxidized nicotinamide adenine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_1902688 GO:1902685 biolink:BiologicalProcess positive regulation of receptor localization to synapse Any process that activates or increases the frequency, rate or extent of receptor localization to synapse. go.json activation of receptor localisation to synapse|activation of receptor localization to synapse|positive regulation of receptor localisation to synapse|up regulation of receptor localisation to synapse|up regulation of receptor localization to synapse|up-regulation of receptor localisation to synapse|up-regulation of receptor localization to synapse|upregulation of receptor localisation to synapse|upregulation of receptor localization to synapse http://purl.obolibrary.org/obo/GO_1902685 GO:1902686 biolink:BiologicalProcess mitochondrial outer membrane permeabilization involved in programmed cell death The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process. go.json MPT involved in PCD|MPT involved in caspase-independent apoptosis|MPT involved in caspase-independent cell death|MPT involved in non-apoptotic programmed cell death|MPT involved in nonapoptotic programmed cell death|MPT involved in programmed cell death|MPT involved in regulated cell death|mitochondrial membrane permeability transition involved in PCD|mitochondrial membrane permeability transition involved in caspase-independent apoptosis|mitochondrial membrane permeability transition involved in caspase-independent cell death|mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death|mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death|mitochondrial membrane permeability transition involved in programmed cell death|mitochondrial membrane permeability transition involved in regulated cell death|mitochondrial membrane permeabilization involved in PCD|mitochondrial membrane permeabilization involved in caspase-independent apoptosis|mitochondrial membrane permeabilization involved in caspase-independent cell death|mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death|mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death|mitochondrial membrane permeabilization involved in programmed cell death|mitochondrial membrane permeabilization involved in regulated cell death|mitochondrial outer membrane permeabilization during programmed cell death|mitochondrial permeability transition involved in PCD|mitochondrial permeability transition involved in caspase-independent apoptosis|mitochondrial permeability transition involved in caspase-independent cell death|mitochondrial permeability transition involved in non-apoptotic programmed cell death|mitochondrial permeability transition involved in nonapoptotic programmed cell death|mitochondrial permeability transition involved in programmed cell death|mitochondrial permeability transition involved in regulated cell death|mitochondrion outer membrane permeabilization involved in programmed cell death|positive regulation of mitochondrial membrane permeability involved in PCD|positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis|positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death|positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in programmed cell death|positive regulation of mitochondrial membrane permeability involved in regulated cell death|positive regulation of transport across mitochondrial membrane involved in PCD|positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis|positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death|positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death|positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death|positive regulation of transport across mitochondrial membrane involved in programmed cell death|positive regulation of transport across mitochondrial membrane involved in regulated cell death http://purl.obolibrary.org/obo/GO_1902686 GO:0060240 biolink:BiologicalProcess negative regulation of signal transduction involved in conjugation with cellular fusion Any process that decreases the rate, frequency or extent of the series signal transduction involved in conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0060240 GO:1902683 biolink:BiologicalProcess regulation of receptor localization to synapse Any process that modulates the frequency, rate or extent of receptor localization to synapse. go.json regulation of receptor localisation to synapse http://purl.obolibrary.org/obo/GO_1902683 GO:0060241 biolink:MolecularActivity lysozyme inhibitor activity Binds to and stops, prevents or reduces the activity of lysozyme. go.json http://purl.obolibrary.org/obo/GO_0060241 GO:0060242 biolink:BiologicalProcess contact inhibition The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation. Wikipedia:Contact_inhibition go.json detection of cell density by contact stimulus|detection of cell density by contact stimulus involved in contact inhibition http://purl.obolibrary.org/obo/GO_0060242 GO:1902684 biolink:BiologicalProcess negative regulation of receptor localization to synapse Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse. go.json down regulation of receptor localisation to synapse|down regulation of receptor localization to synapse|down-regulation of receptor localisation to synapse|down-regulation of receptor localization to synapse|downregulation of receptor localisation to synapse|downregulation of receptor localization to synapse|inhibition of receptor localisation to synapse|inhibition of receptor localization to synapse|negative regulation of receptor localisation to synapse http://purl.obolibrary.org/obo/GO_1902684 GO:0060243 biolink:BiologicalProcess negative regulation of cell growth involved in contact inhibition The negative regulation of cell growth in response to increased cell density. go.json http://purl.obolibrary.org/obo/GO_0060243 GO:1902692 biolink:BiologicalProcess regulation of neuroblast proliferation Any process that modulates the frequency, rate or extent of neuroblast proliferation. go.json http://purl.obolibrary.org/obo/GO_1902692 GO:0035232 biolink:BiologicalProcess germ cell attraction The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target. go.json http://purl.obolibrary.org/obo/GO_0035232 GO:0060244 biolink:BiologicalProcess negative regulation of cell proliferation involved in contact inhibition Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density. go.json http://purl.obolibrary.org/obo/GO_0060244 GO:1902693 biolink:CellularComponent superoxide dismutase complex A protein complex which is capable of superoxide dismutase activity. go.json http://purl.obolibrary.org/obo/GO_1902693 GO:0035233 biolink:BiologicalProcess germ cell repulsion The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue. go.json http://purl.obolibrary.org/obo/GO_0035233 GO:1902690 biolink:BiologicalProcess positive regulation of NAD metabolic process Any process that activates or increases the frequency, rate or extent of NAD metabolic process. go.json activation of NAD (oxidized) metabolic process|activation of NAD (oxidized) metabolism|activation of NAD metabolic process|activation of NAD metabolism|activation of NAD phosphorylation and dephosphorylation|activation of nicotinamide adenine dinucleotide metabolic process|activation of nicotinamide adenine dinucleotide metabolism|activation of oxidized NAD metabolic process|activation of oxidized NAD metabolism|activation of oxidized nicotinamide adenine dinucleotide metabolic process|activation of oxidized nicotinamide adenine dinucleotide metabolism|positive regulation of NAD (oxidized) metabolic process|positive regulation of NAD (oxidized) metabolism|positive regulation of NAD metabolism|positive regulation of NAD phosphorylation and dephosphorylation|positive regulation of nicotinamide adenine dinucleotide metabolic process|positive regulation of nicotinamide adenine dinucleotide metabolism|positive regulation of oxidized NAD metabolic process|positive regulation of oxidized NAD metabolism|positive regulation of oxidized nicotinamide adenine dinucleotide metabolic process|positive regulation of oxidized nicotinamide adenine dinucleotide metabolism|up regulation of NAD (oxidized) metabolic process|up regulation of NAD (oxidized) metabolism|up regulation of NAD metabolic process|up regulation of NAD metabolism|up regulation of NAD phosphorylation and dephosphorylation|up regulation of nicotinamide adenine dinucleotide metabolic process|up regulation of nicotinamide adenine dinucleotide metabolism|up regulation of oxidized NAD metabolic process|up regulation of oxidized NAD metabolism|up regulation of oxidized nicotinamide adenine dinucleotide metabolic process|up regulation of oxidized nicotinamide adenine dinucleotide metabolism|up-regulation of NAD (oxidized) metabolic process|up-regulation of NAD (oxidized) metabolism|up-regulation of NAD metabolic process|up-regulation of NAD metabolism|up-regulation of NAD phosphorylation and dephosphorylation|up-regulation of nicotinamide adenine dinucleotide metabolic process|up-regulation of nicotinamide adenine dinucleotide metabolism|up-regulation of oxidized NAD metabolic process|up-regulation of oxidized NAD metabolism|up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process|up-regulation of oxidized nicotinamide adenine dinucleotide metabolism|upregulation of NAD (oxidized) metabolic process|upregulation of NAD (oxidized) metabolism|upregulation of NAD metabolic process|upregulation of NAD metabolism|upregulation of NAD phosphorylation and dephosphorylation|upregulation of nicotinamide adenine dinucleotide metabolic process|upregulation of nicotinamide adenine dinucleotide metabolism|upregulation of oxidized NAD metabolic process|upregulation of oxidized NAD metabolism|upregulation of oxidized nicotinamide adenine dinucleotide metabolic process|upregulation of oxidized nicotinamide adenine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_1902690 GO:2001220 biolink:BiologicalProcess obsolete negative regulation of G2 phase of mitotic cell cycle OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of G2 phase of mitotic cell cycle. go.json negative regulation of G2 phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2001220 GO:0060245 biolink:BiologicalProcess detection of cell density The series of events in which information about the density of cells in a population is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0060245 GO:0035234 biolink:BiologicalProcess ectopic germ cell programmed cell death Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. go.json programmed cell death of ectopic germ cells|programmed cell death, ectopic germ cells http://purl.obolibrary.org/obo/GO_0035234 GO:1902691 biolink:BiologicalProcess respiratory basal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell. go.json airway basal cell differentiation http://purl.obolibrary.org/obo/GO_1902691 GO:0035235 biolink:BiologicalProcess ionotropic glutamate receptor signaling pathway The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json ionotropic glutamate receptor signalling pathway http://purl.obolibrary.org/obo/GO_0035235 GO:0060246 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060246 GO:2001221 biolink:BiologicalProcess obsolete positive regulation of G2 phase of mitotic cell cycle OBSOLETE. Any process that activates or increases the frequency, rate or extent of G2 phase of mitotic cell cycle. go.json positive regulation of G2 phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_2001221 GO:2001222 biolink:BiologicalProcess regulation of neuron migration Any process that modulates the frequency, rate or extent of neuron migration. go.json regulation of neuron chemotaxis|regulation of neuron guidance|regulation of neuronal migration http://purl.obolibrary.org/obo/GO_2001222 GO:0060247 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060247 GO:0035236 biolink:MolecularActivity proctolin receptor activity Combining with the neuropeptide proctolin, to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0035236 GO:2001223 biolink:BiologicalProcess negative regulation of neuron migration Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. go.json negative regulation of neuron chemotaxis|negative regulation of neuron guidance|negative regulation of neuronal migration http://purl.obolibrary.org/obo/GO_2001223 GO:0060248 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060248 GO:0035237 biolink:MolecularActivity corazonin receptor activity Combining with the neuropeptide corazonin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0035237 GO:0035238 biolink:BiologicalProcess vitamin A biosynthetic process The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids. go.json vitamin A anabolism|vitamin A biosynthesis|vitamin A formation|vitamin A synthesis http://purl.obolibrary.org/obo/GO_0035238 GO:2001224 biolink:BiologicalProcess positive regulation of neuron migration Any process that activates or increases the frequency, rate or extent of neuron migration. go.json positive regulation of neuron chemotaxis|positive regulation of neuron guidance|positive regulation of neuronal migration http://purl.obolibrary.org/obo/GO_2001224 GO:0098839 biolink:CellularComponent postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. go.json http://purl.obolibrary.org/obo/GO_0098839 goslim_synapse GO:0060249 biolink:BiologicalProcess anatomical structure homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. go.json anatomical structure maintenance http://purl.obolibrary.org/obo/GO_0060249 GO:0035239 biolink:BiologicalProcess tube morphogenesis The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. go.json http://purl.obolibrary.org/obo/GO_0035239 GO:2001225 biolink:BiologicalProcess regulation of chloride transport Any process that modulates the frequency, rate or extent of chloride transport. go.json http://purl.obolibrary.org/obo/GO_2001225 GO:0098837 biolink:CellularComponent postsynaptic recycling endosome A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. go.json postsynaptic endosomal recycling compartment|postsynaptic recycling outpost http://purl.obolibrary.org/obo/GO_0098837 goslim_synapse GO:0098838 biolink:BiologicalProcess folate transmembrane transport The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane. go.json folic acid transmembrane transport|reduced folate transmembrane transport http://purl.obolibrary.org/obo/GO_0098838 GO:0098835 biolink:CellularComponent presynaptic endocytic zone membrane The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. go.json http://purl.obolibrary.org/obo/GO_0098835 goslim_synapse GO:0098836 biolink:CellularComponent cytoskeleton of dendritic spine The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodeling in response to postsynaptic signaling. go.json http://purl.obolibrary.org/obo/GO_0098836 GO:0098833 biolink:CellularComponent presynaptic endocytic zone A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. go.json http://purl.obolibrary.org/obo/GO_0098833 goslim_synapse GO:0098834 biolink:CellularComponent presynaptic endocytic zone cytoplasmic component The cytoplasmic component of the presynaptic endocytic zone. go.json cortex of presynaptic endocytic zone http://purl.obolibrary.org/obo/GO_0098834 goslim_synapse GO:0098831 biolink:CellularComponent presynaptic active zone cytoplasmic component A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. go.json cortex of presynaptic active zone|presynaptic zone cortex http://purl.obolibrary.org/obo/GO_0098831 goslim_synapse GO:0035230 biolink:CellularComponent cytoneme A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um. Wikipedia:Membrane_nanotube go.json membrane nanotube http://purl.obolibrary.org/obo/GO_0035230 goslim_pir GO:0035231 biolink:BiologicalProcess cytoneme assembly Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. go.json cytoneme biogenesis http://purl.obolibrary.org/obo/GO_0035231 GO:0098832 biolink:CellularComponent peri-centrosomal recycling endosome A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes. go.json http://purl.obolibrary.org/obo/GO_0098832 GO:0098884 biolink:BiologicalProcess postsynaptic neurotransmitter receptor internalization A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle. go.json postsynaptic neurotransmitter receptor endocytosis http://purl.obolibrary.org/obo/GO_0098884 goslim_synapse GO:0098885 biolink:BiologicalProcess modification of postsynaptic actin cytoskeleton Any process that modifies the structure of a postsynaptic actin cytoskeleton. go.json postsynaptic actin cytoskeleton remodelling http://purl.obolibrary.org/obo/GO_0098885 goslim_synapse GO:0098882 biolink:MolecularActivity structural constituent of presynaptic active zone The action of a molecule that contributes to the structural integrity of a presynaptic active zone. go.json structural constituent of active zone http://purl.obolibrary.org/obo/GO_0098882 goslim_synapse GO:0098883 biolink:BiologicalProcess synapse pruning A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. go.json synapse clearance|synapse disassembly|synapse elimination|synapse removal http://purl.obolibrary.org/obo/GO_0098883 goslim_synapse GO:0098880 biolink:BiologicalProcess maintenance of postsynaptic specialization structure A process which maintains the organization and the arrangement of proteins in the presynaptic specialization. go.json http://purl.obolibrary.org/obo/GO_0098880 goslim_synapse GO:0098881 biolink:BiologicalProcess exocytic insertion of neurotransmitter receptor to plasma membrane The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion. go.json neurotransmitter receptor insertion http://purl.obolibrary.org/obo/GO_0098881 goslim_synapse GO:0035229 biolink:BiologicalProcess positive regulation of glutamate-cysteine ligase activity Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate. go.json activation of glutamate-cysteine ligase activity|stimulation of glutamate-cysteine ligase activity|up regulation of glutamate-cysteine ligase activity|up-regulation of glutamate-cysteine ligase activity|upregulation of glutamate-cysteine ligase activity http://purl.obolibrary.org/obo/GO_0035229 gocheck_do_not_annotate GO:1902698 biolink:BiologicalProcess pentose catabolic process to butyrate The chemical reactions and pathways resulting in the breakdown of pentose to butyrate. go.json acidogenesis|pentose breakdown to butyrate|pentose catabolism to butyrate|pentose degradation to butyrate http://purl.obolibrary.org/obo/GO_1902698 GO:0060270 biolink:BiologicalProcess main body follicle cell migration The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte. go.json http://purl.obolibrary.org/obo/GO_0060270 GO:1902699 biolink:BiologicalProcess pentose catabolic process to acetate The chemical reactions and pathways resulting in the breakdown of pentose to acetate. go.json acidogenesis|pentose breakdown to acetate|pentose catabolism to acetate|pentose degradation to acetate http://purl.obolibrary.org/obo/GO_1902699 GO:0060271 biolink:BiologicalProcess cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. Reactome:R-HSA-5617833.2 go.json ciliogenesis|cilium biogenesis|cilium formation|cilium morphogenesis|cilium organization|microtubule-based flagellum assembly http://purl.obolibrary.org/obo/GO_0060271 GO:0060272 biolink:BiologicalProcess embryonic skeletal joint morphogenesis The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton. go.json http://purl.obolibrary.org/obo/GO_0060272 GO:1902696 biolink:BiologicalProcess glycine catabolic process to isobutanol The chemical reactions and pathways resulting in the breakdown of glycine to isobutanol. go.json glycine breakdown to isobutanol|glycine catabolism to isobutanol|glycine degradation to isobutanol http://purl.obolibrary.org/obo/GO_1902696 GO:1902697 biolink:BiologicalProcess valine catabolic process to isobutanol The chemical reactions and pathways resulting in the breakdown of valine to isobutanol. go.json valine breakdown to isobutanol|valine catabolism to isobutanol|valine degradation to isobutanol http://purl.obolibrary.org/obo/GO_1902697 GO:0060273 biolink:BiologicalProcess crying behavior The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli. go.json http://purl.obolibrary.org/obo/GO_0060273 GO:1902694 biolink:CellularComponent superoxide dismutase copper chaperone complex A protein complex which is capable of superoxide dismutase copper chaperone activity. go.json http://purl.obolibrary.org/obo/GO_1902694 GO:0060274 biolink:BiologicalProcess maintenance of stationary phase The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment. go.json http://purl.obolibrary.org/obo/GO_0060274 GO:1902695 biolink:CellularComponent metallochaperone complex A protein complex which is capable of metallochaperone activity. go.json http://purl.obolibrary.org/obo/GO_1902695 GO:0060275 biolink:BiologicalProcess maintenance of stationary phase in response to starvation The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment. go.json http://purl.obolibrary.org/obo/GO_0060275 GO:0035221 biolink:BiologicalProcess genital disc pattern formation The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc. go.json http://purl.obolibrary.org/obo/GO_0035221 GO:0060276 biolink:BiologicalProcess maintenance of stationary phase in response to toxin The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment. go.json http://purl.obolibrary.org/obo/GO_0060276 GO:0060277 biolink:BiologicalProcess obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle. go.json negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0060277 GO:0035222 biolink:BiologicalProcess wing disc pattern formation The process giving rise to the pattern of cell differentiation in the wing imaginal disc. go.json http://purl.obolibrary.org/obo/GO_0035222 GO:0035223 biolink:BiologicalProcess leg disc pattern formation The process that gives rise to the patterns of cell differentiation in the leg imaginal disc. go.json http://purl.obolibrary.org/obo/GO_0035223 GO:0060278 biolink:BiologicalProcess regulation of ovulation Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. go.json http://purl.obolibrary.org/obo/GO_0060278 GO:0035224 biolink:BiologicalProcess genital disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium). go.json http://purl.obolibrary.org/obo/GO_0035224 GO:0060279 biolink:BiologicalProcess positive regulation of ovulation Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. go.json http://purl.obolibrary.org/obo/GO_0060279 GO:0035225 biolink:BiologicalProcess determination of genital disc primordium Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two. go.json http://purl.obolibrary.org/obo/GO_0035225 GO:0035226 biolink:MolecularActivity glutamate-cysteine ligase catalytic subunit binding Binding to the catalytic subunit of glutamate-cysteine ligase. go.json http://purl.obolibrary.org/obo/GO_0035226 GO:0035227 biolink:BiologicalProcess regulation of glutamate-cysteine ligase activity Any process that modulates the activity of glutamate-cysteine ligase. go.json http://purl.obolibrary.org/obo/GO_0035227 gocheck_do_not_annotate GO:0035228 biolink:BiologicalProcess negative regulation of glutamate-cysteine ligase activity Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase. go.json down regulation of glutamate-cysteine ligase activity|down-regulation of glutamate-cysteine ligase activity|downregulation of glutamate-cysteine ligase activity|inhibition of glutamate-cysteine ligase activity http://purl.obolibrary.org/obo/GO_0035228 gocheck_do_not_annotate GO:0098888 biolink:CellularComponent extrinsic component of presynaptic membrane The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic component of presynaptic plasma membrane http://purl.obolibrary.org/obo/GO_0098888 goslim_synapse GO:0098889 biolink:CellularComponent obsolete intrinsic component of presynaptic membrane OBSOLETE. The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to presynaptic membrane True http://purl.obolibrary.org/obo/GO_0098889 GO:0098886 biolink:BiologicalProcess modification of dendritic spine Any process that modifies the structure of a dendritic spine. go.json http://purl.obolibrary.org/obo/GO_0098886 GO:0098887 biolink:BiologicalProcess neurotransmitter receptor transport, endosome to postsynaptic membrane The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. go.json postsynaptic neurotransmitter receptor endosomal trafficking http://purl.obolibrary.org/obo/GO_0098887 goslim_synapse GO:0035220 biolink:BiologicalProcess wing disc development Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura. go.json http://purl.obolibrary.org/obo/GO_0035220 GO:0098895 biolink:CellularComponent postsynaptic endosome membrane The lipid bilayer surrounding a postsynaptic endosome. go.json http://purl.obolibrary.org/obo/GO_0098895 goslim_synapse GO:0098896 biolink:CellularComponent postsynaptic early endosome membrane The lipid bilayer surrounding a postsynaptic early endosome. go.json http://purl.obolibrary.org/obo/GO_0098896 goslim_synapse GO:0098893 biolink:CellularComponent extrinsic component of postsynaptic endocytic zone The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098893 goslim_synapse GO:0098894 biolink:CellularComponent extrinsic component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098894 goslim_synapse GO:0098891 biolink:CellularComponent extrinsic component of presynaptic active zone membrane The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098891 goslim_synapse GO:0098892 biolink:CellularComponent extrinsic component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098892 goslim_synapse GO:0098890 biolink:CellularComponent extrinsic component of postsynaptic membrane The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098890 goslim_synapse GO:0035218 biolink:BiologicalProcess leg disc development Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura. go.json http://purl.obolibrary.org/obo/GO_0035218 GO:0035219 biolink:BiologicalProcess prothoracic disc development Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle. go.json http://purl.obolibrary.org/obo/GO_0035219 GO:0060260 biolink:BiologicalProcess regulation of transcription initiation by RNA polymerase II Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. go.json regulation of transcription initiation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0060260 GO:0060261 biolink:BiologicalProcess positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. go.json positive regulation of transcription initiation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0060261 GO:0060262 biolink:BiologicalProcess negative regulation of N-terminal protein palmitoylation Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0060262 GO:0060263 biolink:BiologicalProcess regulation of respiratory burst Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0060263 GO:0060264 biolink:BiologicalProcess regulation of respiratory burst involved in inflammatory response Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json regulation of respiratory burst involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0060264 GO:0035210 biolink:BiologicalProcess prepupal development The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation. go.json http://purl.obolibrary.org/obo/GO_0035210 GO:0060265 biolink:BiologicalProcess positive regulation of respiratory burst involved in inflammatory response Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json positive regulation of respiratory burst involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0060265 GO:0035211 biolink:BiologicalProcess spermathecum morphogenesis The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk. go.json http://purl.obolibrary.org/obo/GO_0035211 GO:0060266 biolink:BiologicalProcess negative regulation of respiratory burst involved in inflammatory response Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json negative regulation of respiratory burst involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_0060266 GO:0060267 biolink:BiologicalProcess positive regulation of respiratory burst Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0060267 GO:0035212 biolink:BiologicalProcess cell competition in a multicellular organism Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. go.json http://purl.obolibrary.org/obo/GO_0035212 GO:0035213 biolink:BiologicalProcess clypeo-labral disc development The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite. go.json development of structures derived from the clypeo-labral disc http://purl.obolibrary.org/obo/GO_0035213 GO:0060268 biolink:BiologicalProcess negative regulation of respiratory burst Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0060268 GO:0035214 biolink:BiologicalProcess eye-antennal disc development Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps. go.json http://purl.obolibrary.org/obo/GO_0035214 GO:0060269 biolink:BiologicalProcess centripetally migrating follicle cell migration The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte. go.json http://purl.obolibrary.org/obo/GO_0060269 GO:0035215 biolink:BiologicalProcess genital disc development Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia. go.json http://purl.obolibrary.org/obo/GO_0035215 GO:0035216 biolink:BiologicalProcess haltere disc development Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. go.json http://purl.obolibrary.org/obo/GO_0035216 GO:0035217 biolink:BiologicalProcess labial disc development Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis. go.json http://purl.obolibrary.org/obo/GO_0035217 GO:0098899 biolink:CellularComponent spine apparatus lumen The volume enclosed by the spine apparatus membrane. go.json http://purl.obolibrary.org/obo/GO_0098899 goslim_synapse GO:0098897 biolink:CellularComponent spine apparatus membrane The lipid bilayer surrounding the spine apparatus. go.json http://purl.obolibrary.org/obo/GO_0098897 goslim_synapse GO:0098898 biolink:CellularComponent dense core granule lumen The volume enclosed by the dense core granule membrane. go.json dense core vesicle lumen http://purl.obolibrary.org/obo/GO_0098898 GO:0098862 biolink:CellularComponent cluster of actin-based cell projections A cell part consisting of multiple, closely packed actin-based cell projections. go.json http://purl.obolibrary.org/obo/GO_0098862 GO:0098863 biolink:BiologicalProcess nuclear migration by microtubule mediated pushing forces The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules. go.json http://purl.obolibrary.org/obo/GO_0098863 GO:0098860 biolink:CellularComponent actin filament bundle of stereocilium A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium. Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0098860 GO:0098861 biolink:CellularComponent actin filament bundle of filopodium A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex. go.json http://purl.obolibrary.org/obo/GO_0098861 GO:0035207 biolink:BiologicalProcess negative regulation of hemocyte proliferation Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. go.json down regulation of hemocyte proliferation|down-regulation of hemocyte proliferation|downregulation of hemocyte proliferation|inhibition of hemocyte proliferation|negative regulation of arthropod blood cell proliferation http://purl.obolibrary.org/obo/GO_0035207 GO:0060290 biolink:BiologicalProcess transdifferentiation The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate. Wikipedia:Transdifferentiation go.json http://purl.obolibrary.org/obo/GO_0060290 GO:0060291 biolink:BiologicalProcess long-term synaptic potentiation A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. go.json LTP|long-term potentiation http://purl.obolibrary.org/obo/GO_0060291 GO:0035208 biolink:BiologicalProcess positive regulation of hemocyte proliferation Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster. go.json activation of hemocyte proliferation|positive regulation of arthropod blood cell proliferation|stimulation of hemocyte proliferation|up regulation of hemocyte proliferation|up-regulation of hemocyte proliferation|upregulation of hemocyte proliferation http://purl.obolibrary.org/obo/GO_0035208 GO:0060292 biolink:BiologicalProcess long-term synaptic depression A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. go.json LTD|long term depression|long term synaptic depression http://purl.obolibrary.org/obo/GO_0060292 GO:0035209 biolink:BiologicalProcess pupal development The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis. go.json http://purl.obolibrary.org/obo/GO_0035209 GO:0060293 biolink:CellularComponent germ plasm Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line. Wikipedia:Germ_plasm go.json http://purl.obolibrary.org/obo/GO_0060293 GO:0060294 biolink:BiologicalProcess cilium movement involved in cell motility Movement of cilia mediated by motor proteins that contributes to the movement of a cell. go.json http://purl.obolibrary.org/obo/GO_0060294 GO:0060295 biolink:BiologicalProcess regulation of cilium movement involved in cell motility Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. go.json http://purl.obolibrary.org/obo/GO_0060295 GO:0060296 biolink:BiologicalProcess regulation of cilium beat frequency involved in ciliary motility Any process that modulates the frequency of cilium beating involved in ciliary motility. go.json http://purl.obolibrary.org/obo/GO_0060296 GO:0060297 biolink:BiologicalProcess regulation of sarcomere organization Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. go.json regulation of sarcomere organisation http://purl.obolibrary.org/obo/GO_0060297 GO:0060298 biolink:BiologicalProcess positive regulation of sarcomere organization Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. go.json positive regulation of sarcomere organisation http://purl.obolibrary.org/obo/GO_0060298 GO:0060299 biolink:BiologicalProcess negative regulation of sarcomere organization Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. go.json negative regulation of sarcomere organisation http://purl.obolibrary.org/obo/GO_0060299 GO:0035200 biolink:BiologicalProcess leg disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc. go.json http://purl.obolibrary.org/obo/GO_0035200 GO:0035201 biolink:BiologicalProcess leg disc anterior/posterior lineage restriction Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment. go.json http://purl.obolibrary.org/obo/GO_0035201 GO:0035202 biolink:BiologicalProcess tracheal pit formation in open tracheal system Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster. go.json tracheal placode invagination|tracheal sac formation http://purl.obolibrary.org/obo/GO_0035202 GO:0035203 biolink:BiologicalProcess regulation of lamellocyte differentiation Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. go.json http://purl.obolibrary.org/obo/GO_0035203 GO:0035204 biolink:BiologicalProcess negative regulation of lamellocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. go.json down regulation of lamellocyte differentiation|down-regulation of lamellocyte differentiation|downregulation of lamellocyte differentiation|inhibition of lamellocyte differentiation http://purl.obolibrary.org/obo/GO_0035204 GO:0035205 biolink:BiologicalProcess positive regulation of lamellocyte differentiation Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. go.json activation of lamellocyte differentiation|stimulation of lamellocyte differentiation|up regulation of lamellocyte differentiation|up-regulation of lamellocyte differentiation|upregulation of lamellocyte differentiation http://purl.obolibrary.org/obo/GO_0035205 GO:0035206 biolink:BiologicalProcess regulation of hemocyte proliferation Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. go.json regulation of arthropod blood cell proliferation http://purl.obolibrary.org/obo/GO_0035206 GO:0098868 biolink:BiologicalProcess bone growth The increase in size or mass of a bone that contributes to the shaping of that bone. go.json http://purl.obolibrary.org/obo/GO_0098868 GO:0098869 biolink:BiologicalProcess cellular oxidant detoxification Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. go.json http://purl.obolibrary.org/obo/GO_0098869 GO:0098866 biolink:BiologicalProcess multivesicular body fusion to apical plasma membrane The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell. go.json http://purl.obolibrary.org/obo/GO_0098866 GO:0098867 biolink:BiologicalProcess intramembranous bone growth The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. go.json http://purl.obolibrary.org/obo/GO_0098867 GO:0098864 biolink:BiologicalProcess symbiont-mediated stabilization of host tight cell-cell junction The process in which a symbiont organism that stabilizes the its host tight cell-cell junctions, making them less dynamic. The tight junction is a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other, and plays a role in the inflammatory response of the host. go.json modification by symbiont of host tight cell-cell junction|stabilization of host tight cell-cell junction http://purl.obolibrary.org/obo/GO_0098864 GO:0098865 biolink:BiologicalProcess symbiont-mediated perturbation of host tight cell-cell junction The process in which an organism effects a change that impairs the structure or temporarily subverts the tight cell-cell junctions between cells of the host. Tight cell-cell junctions, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. go.json disruption by symbiont of host tight cell-cell junction|disruption of host tight cell-cell junction|modification by symbiont of host bicellular tight junctions|symbiont-mediated disruption of host tight cell-cell junction http://purl.obolibrary.org/obo/GO_0098865 GO:0098873 biolink:BiologicalProcess neuronal action potential back-propagation Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma. go.json http://purl.obolibrary.org/obo/GO_0098873 GO:0098874 biolink:BiologicalProcess spike train A series of sequential, propagated action potentials occurring in a single cell. go.json burst of action potentials|spike-train http://purl.obolibrary.org/obo/GO_0098874 GO:0098871 biolink:CellularComponent postsynaptic actin cytoskeleton The actin cytoskeleton that is part of a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0098871 goslim_synapse GO:0098872 biolink:MolecularActivity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse. go.json G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels http://purl.obolibrary.org/obo/GO_0098872 goslim_synapse GO:0098870 biolink:BiologicalProcess action potential propagation The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold. go.json http://purl.obolibrary.org/obo/GO_0098870 GO:0060280 biolink:BiologicalProcess negative regulation of ovulation Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. go.json http://purl.obolibrary.org/obo/GO_0060280 GO:0060281 biolink:BiologicalProcess regulation of oocyte development Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0060281 GO:0060282 biolink:BiologicalProcess positive regulation of oocyte development Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0060282 GO:0060283 biolink:BiologicalProcess negative regulation of oocyte development Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0060283 GO:0060284 biolink:BiologicalProcess regulation of cell development Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0060284 GO:0060285 biolink:BiologicalProcess cilium-dependent cell motility Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. go.json ciliary cell motility|cilium cell motility|microtubule-based flagellar cell motility http://purl.obolibrary.org/obo/GO_0060285 GO:0060286 biolink:BiologicalProcess obsolete flagellar cell motility OBSOLETE. Cell motility due to the motion of one or more flagella. go.json flagellar cell motility True http://purl.obolibrary.org/obo/GO_0060286 GO:0060287 biolink:BiologicalProcess epithelial cilium movement involved in determination of left/right asymmetry The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves. go.json Kuppfer's vesicle cilium movement involved in determination of left/right asymmetry|cilium movement involved in determinationof L/R asymmetry|nodal cilium movement involved in determination of left/right asymmetry http://purl.obolibrary.org/obo/GO_0060287 GO:0060288 biolink:BiologicalProcess formation of a compartment boundary Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier. go.json compartment boundary formation http://purl.obolibrary.org/obo/GO_0060288 GO:0060289 biolink:BiologicalProcess compartment boundary maintenance A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier. go.json http://purl.obolibrary.org/obo/GO_0060289 GO:0098879 biolink:MolecularActivity structural constituent of postsynaptic specialization The action of a molecule that contributes to the structural integrity of a postsynaptic specialization. go.json http://purl.obolibrary.org/obo/GO_0098879 goslim_synapse GO:0098877 biolink:BiologicalProcess neurotransmitter receptor transport to plasma membrane The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. go.json http://purl.obolibrary.org/obo/GO_0098877 goslim_synapse GO:0098878 biolink:CellularComponent neurotransmitter receptor complex Any protein complex that is capable of functioning as a neurotransmitter receptor. go.json http://purl.obolibrary.org/obo/GO_0098878 GO:0098875 biolink:CellularComponent epididymosome A microvesicle of the epididymal fluid, from which spermatozoa aquire membrane proteins. go.json http://purl.obolibrary.org/obo/GO_0098875 GO:0098876 biolink:BiologicalProcess vesicle-mediated transport to the plasma membrane The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. go.json http://purl.obolibrary.org/obo/GO_0098876 GO:0050822 biolink:BiologicalProcess peptide stabilization Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded. go.json peptide stabilisation|peptide stabilization activity http://purl.obolibrary.org/obo/GO_0050822 GO:0050823 biolink:BiologicalProcess peptide antigen stabilization Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded. go.json peptide antigen stabilization activity http://purl.obolibrary.org/obo/GO_0050823 GO:0050820 biolink:BiologicalProcess positive regulation of coagulation Any process that activates or increases the frequency, rate or extent of coagulation. go.json activation of coagulation|positive regulation of clotting|stimulation of coagulation|up regulation of coagulation|up-regulation of coagulation|upregulation of coagulation http://purl.obolibrary.org/obo/GO_0050820 GO:0050821 biolink:BiologicalProcess protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. go.json lysosomal protein stabilization|positive regulation of protein stability|protein sequestering|protein stabilisation|protein stabilization activity http://purl.obolibrary.org/obo/GO_0050821 goslim_chembl GO:0050826 biolink:BiologicalProcess response to freezing Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. go.json antifreeze activity|ice nucleation inhibitor activity http://purl.obolibrary.org/obo/GO_0050826 GO:0050827 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050827 GO:0050824 biolink:MolecularActivity obsolete water binding OBSOLETE. Binding to water (H2O). go.json True http://purl.obolibrary.org/obo/GO_0050824 GO:0050825 biolink:MolecularActivity ice binding Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. go.json antifreeze activity|ice crystal binding|ice nucleation activity|ice nucleation inhibitor activity http://purl.obolibrary.org/obo/GO_0050825 GO:0050828 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050828 GO:0050829 biolink:BiologicalProcess defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. go.json Gram-negative antibacterial peptide activity|defence response to Gram-negative bacteria|defence response to Gram-negative bacterium|defense response to Gram-negative bacteria http://purl.obolibrary.org/obo/GO_0050829 GO:2001273 biolink:BiologicalProcess obsolete regulation of glucose import in response to insulin stimulus OBSOLETE. Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. go.json regulation of cellular glucose import in response to insulin stimulus True http://purl.obolibrary.org/obo/GO_2001273 GO:2001274 biolink:BiologicalProcess obsolete negative regulation of glucose import in response to insulin stimulus OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose import in response to insulin stimulus. go.json negative regulation of cellular glucose import in response to insulin stimulus True http://purl.obolibrary.org/obo/GO_2001274 GO:2001275 biolink:BiologicalProcess obsolete positive regulation of glucose import in response to insulin stimulus OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. go.json positive regulation of cellular glucose import in response to insulin stimulus True http://purl.obolibrary.org/obo/GO_2001275 GO:2001276 biolink:BiologicalProcess regulation of leucine biosynthetic process Any process that modulates the frequency, rate or extent of leucine biosynthetic process. go.json regulation of leucine anabolism|regulation of leucine biosynthesis|regulation of leucine formation|regulation of leucine synthesis http://purl.obolibrary.org/obo/GO_2001276 GO:2001277 biolink:BiologicalProcess negative regulation of leucine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process. go.json negative regulation of leucine anabolism|negative regulation of leucine biosynthesis|negative regulation of leucine formation|negative regulation of leucine synthesis http://purl.obolibrary.org/obo/GO_2001277 GO:2001278 biolink:BiologicalProcess positive regulation of leucine biosynthetic process Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process. go.json positive regulation of leucine anabolism|positive regulation of leucine biosynthesis|positive regulation of leucine formation|positive regulation of leucine synthesis http://purl.obolibrary.org/obo/GO_2001278 GO:2001279 biolink:BiologicalProcess regulation of unsaturated fatty acid biosynthetic process Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process. go.json regulation of fatty acid desaturation|regulation of polyunsaturated fatty acid biosynthesis|regulation of unsaturated fatty acid anabolism|regulation of unsaturated fatty acid biosynthesis|regulation of unsaturated fatty acid formation|regulation of unsaturated fatty acid synthesis http://purl.obolibrary.org/obo/GO_2001279 GO:2001270 biolink:BiologicalProcess regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. go.json regulation of effector caspase activity http://purl.obolibrary.org/obo/GO_2001270 gocheck_do_not_annotate GO:2001271 biolink:BiologicalProcess negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. go.json negative regulation of effector caspase activity http://purl.obolibrary.org/obo/GO_2001271 gocheck_do_not_annotate GO:2001272 biolink:BiologicalProcess positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. go.json positive regulation of effector caspase activity http://purl.obolibrary.org/obo/GO_2001272 gocheck_do_not_annotate GO:0050830 biolink:BiologicalProcess defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. go.json Gram-positive antibacterial peptide activity|defence response to Gram-positive bacteria|defence response to Gram-positive bacterium|defense response to Gram-positive bacteria http://purl.obolibrary.org/obo/GO_0050830 GO:0050833 biolink:MolecularActivity pyruvate transmembrane transporter activity Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. Reactome:R-HSA-372342 go.json monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity http://purl.obolibrary.org/obo/GO_0050833 GO:0050834 biolink:BiologicalProcess molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. RESID:AA0355 go.json http://purl.obolibrary.org/obo/GO_0050834 gocheck_do_not_annotate GO:0050831 biolink:BiologicalProcess male-specific defense response to bacterium A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism. go.json male-specific antibacterial peptide activity|male-specific defence response to bacteria|male-specific defence response to bacterium|male-specific defense response to bacteria http://purl.obolibrary.org/obo/GO_0050831 GO:0050832 biolink:BiologicalProcess defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. go.json defence response to fungi|defence response to fungus|defense response to fungi|defense response to fungus, incompatible interaction|resistance response to pathogenic fungi|resistance response to pathogenic fungus|response to parasitic fungi|response to parasitic fungus http://purl.obolibrary.org/obo/GO_0050832 GO:0050837 biolink:BiologicalProcess peptide cross-linking via L-cysteinyl-L-selenocysteine The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P. RESID:AA0358 go.json http://purl.obolibrary.org/obo/GO_0050837 gocheck_do_not_annotate GO:0050838 biolink:BiologicalProcess peptidyl-5-hydroxy-L-lysine trimethylation The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. RESID:AA0359 go.json http://purl.obolibrary.org/obo/GO_0050838 gocheck_do_not_annotate GO:0050835 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. RESID:AA0356 go.json http://purl.obolibrary.org/obo/GO_0050835 gocheck_do_not_annotate GO:0050836 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide. RESID:AA0357 go.json http://purl.obolibrary.org/obo/GO_0050836 gocheck_do_not_annotate GO:0050839 biolink:MolecularActivity cell adhesion molecule binding Binding to a cell adhesion molecule. go.json CAM binding|adhesive extracellular matrix constituent|cell adhesion molecule activity|cell adhesion receptor activity http://purl.obolibrary.org/obo/GO_0050839 GO:2001284 biolink:BiologicalProcess regulation of BMP secretion Any process that modulates the frequency, rate or extent of BMP secretion. go.json regulation of BMP protein secretion|regulation of bone morphogenetic protein secretion http://purl.obolibrary.org/obo/GO_2001284 GO:2001285 biolink:BiologicalProcess negative regulation of BMP secretion Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion. go.json negative regulation of BMP protein secretion|negative regulation of bone morphogenetic protein secretion http://purl.obolibrary.org/obo/GO_2001285 GO:2001286 biolink:BiologicalProcess regulation of caveolin-mediated endocytosis Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis. go.json regulation of caveolae-dependent endocytosis|regulation of caveolae-mediated endocytosis|regulation of caveolin-dependent endocytosis http://purl.obolibrary.org/obo/GO_2001286 GO:2001287 biolink:BiologicalProcess negative regulation of caveolin-mediated endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis. go.json negative regulation of caveolae-dependent endocytosis|negative regulation of caveolae-mediated endocytosis|negative regulation of caveolin-dependent endocytosis http://purl.obolibrary.org/obo/GO_2001287 GO:2001288 biolink:BiologicalProcess positive regulation of caveolin-mediated endocytosis Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis. go.json positive regulation of caveolae-dependent endocytosis|positive regulation of caveolae-mediated endocytosis|positive regulation of caveolin-dependent endocytosis http://purl.obolibrary.org/obo/GO_2001288 GO:2001289 biolink:BiologicalProcess lipid X metabolic process The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate. go.json 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process|2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolism|2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process|2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolism|2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolic process|2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism|lipid X metabolism http://purl.obolibrary.org/obo/GO_2001289 GO:2001280 biolink:BiologicalProcess positive regulation of unsaturated fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process. go.json positive regulation of fatty acid desaturation|positive regulation of polyunsaturated fatty acid biosynthesis|positive regulation of unsaturated fatty acid anabolism|positive regulation of unsaturated fatty acid biosynthesis|positive regulation of unsaturated fatty acid formation|positive regulation of unsaturated fatty acid synthesis http://purl.obolibrary.org/obo/GO_2001280 GO:2001281 biolink:BiologicalProcess regulation of muscle cell chemotaxis toward tendon cell Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell. go.json regulation of muscle cell attraction|regulation of muscle cell chemotaxis towards tendon cell http://purl.obolibrary.org/obo/GO_2001281 GO:2001282 biolink:BiologicalProcess negative regulation of muscle cell chemotaxis toward tendon cell Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells. go.json arrest of muscle cell chemotaxis|negative regulation of muscle cell attraction|negative regulation of muscle cell chemotaxis towards tendon cell http://purl.obolibrary.org/obo/GO_2001282 GO:2001283 biolink:BiologicalProcess Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. go.json ROBO signaling pathway involved in muscle cell attraction|ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell|ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell|ROBO/SLIT signaling pathway involved in muscle cell attraction|ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell|ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell|Roundabout signaling pathway involved in muscle cell attraction|Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell|Roundabout signalling pathway involved in muscle cell attraction|Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell|Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell http://purl.obolibrary.org/obo/GO_2001283 GO:0050840 biolink:MolecularActivity extracellular matrix binding Binding to a component of the extracellular matrix. go.json adhesive extracellular matrix constituent|extracellular matrix constituent binding http://purl.obolibrary.org/obo/GO_0050840 goslim_chembl|goslim_pir GO:0050841 biolink:BiologicalProcess peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. RESID:AA0359 go.json peptidyl trimethyl lysine hydroxylase activity|peptidyl-trimethyl-lysine hydroxylase activity http://purl.obolibrary.org/obo/GO_0050841 gocheck_do_not_annotate GO:0050844 biolink:BiologicalProcess peptidyl-selenocysteine modification The modification of peptidyl-selenocysteine. go.json http://purl.obolibrary.org/obo/GO_0050844 gocheck_do_not_annotate GO:0050845 biolink:BiologicalProcess teichuronic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. go.json teichuronic acid anabolism|teichuronic acid biosynthesis|teichuronic acid formation|teichuronic acid synthesis http://purl.obolibrary.org/obo/GO_0050845 GO:0050842 biolink:BiologicalProcess copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. RESID:AA0355 go.json http://purl.obolibrary.org/obo/GO_0050842 gocheck_do_not_annotate GO:0050843 biolink:BiologicalProcess S-adenosylmethionine catabolic process The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. go.json S-adenosyl methionine catabolic process|S-adenosyl methionine catabolism|S-adenosylmethionine breakdown|S-adenosylmethionine catabolism|S-adenosylmethionine degradation|SAM catabolic process http://purl.obolibrary.org/obo/GO_0050843 GO:0050848 biolink:BiologicalProcess regulation of calcium-mediated signaling Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. go.json regulation of calcium-mediated signalling http://purl.obolibrary.org/obo/GO_0050848 GO:0050849 biolink:BiologicalProcess negative regulation of calcium-mediated signaling Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. go.json down regulation of calcium-mediated signaling|down-regulation of calcium-mediated signaling|downregulation of calcium-mediated signaling|inhibition of calcium-mediated signaling|negative regulation of calcium-mediated signalling http://purl.obolibrary.org/obo/GO_0050849 GO:0050846 biolink:BiologicalProcess teichuronic acid metabolic process The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. go.json teichuronic acid metabolism http://purl.obolibrary.org/obo/GO_0050846 GO:0050847 biolink:BiologicalProcess progesterone receptor signaling pathway The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm. go.json progesterone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0050847 GO:2001295 biolink:BiologicalProcess malonyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A. go.json malonyl-CoA anabolism|malonyl-CoA biosynthesis|malonyl-CoA formation|malonyl-CoA synthesis http://purl.obolibrary.org/obo/GO_2001295 GO:2001296 biolink:BiologicalProcess N(omega)-methyl-L-arginine metabolic process The chemical reactions and pathways involving N(omega)-methyl-L-arginine. go.json N(omega)-methyl-L-arginine metabolism http://purl.obolibrary.org/obo/GO_2001296 GO:2001297 biolink:BiologicalProcess N(omega)-methyl-L-arginine catabolic process The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine. go.json N(omega)-methyl-L-arginine breakdown|N(omega)-methyl-L-arginine catabolism|N(omega)-methyl-L-arginine degradation http://purl.obolibrary.org/obo/GO_2001297 GO:2001298 biolink:BiologicalProcess N(omega),N(omega)-dimethyl-L-arginine metabolic process The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group. go.json N(omega),N(omega)-dimethyl-L-arginine metabolism http://purl.obolibrary.org/obo/GO_2001298 GO:2001299 biolink:BiologicalProcess N(omega),N(omega)-dimethyl-L-arginine catabolic process The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group. go.json N(omega),N(omega)-dimethyl-L-arginine breakdown|N(omega),N(omega)-dimethyl-L-arginine catabolism|N(omega),N(omega)-dimethyl-L-arginine degradation http://purl.obolibrary.org/obo/GO_2001299 GO:2001290 biolink:BiologicalProcess hydroperoxide metabolic process The chemical reactions and pathways involving a hydroperoxide. go.json hydroperoxide metabolism http://purl.obolibrary.org/obo/GO_2001290 GO:2001291 biolink:BiologicalProcess codeine metabolic process The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties. go.json codeine metabolism http://purl.obolibrary.org/obo/GO_2001291 GO:2001292 biolink:BiologicalProcess codeine catabolic process The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties. go.json codeine breakdown|codeine catabolism|codeine degradation http://purl.obolibrary.org/obo/GO_2001292 GO:2001293 biolink:BiologicalProcess malonyl-CoA metabolic process The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A. go.json malonyl-CoA metabolism http://purl.obolibrary.org/obo/GO_2001293 GO:2001294 biolink:BiologicalProcess malonyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A. go.json malonyl-CoA breakdown|malonyl-CoA catabolism|malonyl-CoA degradation http://purl.obolibrary.org/obo/GO_2001294 GO:1902609 biolink:BiologicalProcess (R)-2-hydroxy-alpha-linolenic acid biosynthetic process The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid. go.json (R)-2-hydroxy-alpha-linolenic acid anabolism|(R)-2-hydroxy-alpha-linolenic acid biosynthesis|(R)-2-hydroxy-alpha-linolenic acid formation|(R)-2-hydroxy-alpha-linolenic acid synthesis|2-hydroxy-octadecatrienoic acid biosynthesis http://purl.obolibrary.org/obo/GO_1902609 GO:0050851 biolink:BiologicalProcess antigen receptor-mediated signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. go.json antigen receptor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0050851 GO:0050852 biolink:BiologicalProcess T cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. go.json T lymphocyte receptor signaling pathway|T lymphocyte receptor signalling pathway|T-cell receptor signaling pathway|T-cell receptor signalling pathway|T-lymphocyte receptor signaling pathway|T-lymphocyte receptor signalling pathway|TCR signaling pathway http://purl.obolibrary.org/obo/GO_0050852 GO:1902607 biolink:BiologicalProcess negative regulation of large conductance calcium-activated potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity. go.json down regulation of BK KCa channels|down regulation of BK calcium-activated potassium channel activity|down regulation of BK channel activity|down regulation of large conductance KCa channels|down regulation of large conductance calcium-activated potassium channel activity|down-regulation of BK KCa channels|down-regulation of BK calcium-activated potassium channel activity|down-regulation of BK channel activity|down-regulation of large conductance KCa channels|down-regulation of large conductance calcium-activated potassium channel activity|downregulation of BK KCa channels|downregulation of BK calcium-activated potassium channel activity|downregulation of BK channel activity|downregulation of large conductance KCa channels|downregulation of large conductance calcium-activated potassium channel activity|inhibition of BK KCa channels|inhibition of BK calcium-activated potassium channel activity|inhibition of BK channel activity|inhibition of large conductance KCa channels|inhibition of large conductance calcium-activated potassium channel activity|negative regulation of BK KCa channels|negative regulation of BK calcium-activated potassium channel activity|negative regulation of BK channel activity|negative regulation of large conductance KCa channels http://purl.obolibrary.org/obo/GO_1902607 gocheck_do_not_annotate GO:1902608 biolink:BiologicalProcess positive regulation of large conductance calcium-activated potassium channel activity Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity. go.json activation of BK KCa channels|activation of BK calcium-activated potassium channel activity|activation of BK channel activity|activation of large conductance KCa channels|activation of large conductance calcium-activated potassium channel activity|positive regulation of BK KCa channels|positive regulation of BK calcium-activated potassium channel activity|positive regulation of BK channel activity|positive regulation of large conductance KCa channels|up regulation of BK KCa channels|up regulation of BK calcium-activated potassium channel activity|up regulation of BK channel activity|up regulation of large conductance KCa channels|up regulation of large conductance calcium-activated potassium channel activity|up-regulation of BK KCa channels|up-regulation of BK calcium-activated potassium channel activity|up-regulation of BK channel activity|up-regulation of large conductance KCa channels|up-regulation of large conductance calcium-activated potassium channel activity|upregulation of BK KCa channels|upregulation of BK calcium-activated potassium channel activity|upregulation of BK channel activity|upregulation of large conductance KCa channels|upregulation of large conductance calcium-activated potassium channel activity http://purl.obolibrary.org/obo/GO_1902608 gocheck_do_not_annotate GO:0050850 biolink:BiologicalProcess positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. go.json activation of calcium-mediated signaling|positive regulation of calcium-mediated signalling|stimulation of calcium-mediated signaling|up regulation of calcium-mediated signaling|up-regulation of calcium-mediated signaling|upregulation of calcium-mediated signaling http://purl.obolibrary.org/obo/GO_0050850 GO:0050855 biolink:BiologicalProcess regulation of B cell receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. go.json regulation of B cell receptor signalling pathway|regulation of B lymphocyte receptor signaling pathway|regulation of B lymphocyte receptor signalling pathway|regulation of B-cell receptor signaling pathway|regulation of B-cell receptor signalling pathway|regulation of B-lymphocyte receptor signaling pathway|regulation of B-lymphocyte receptor signalling pathway http://purl.obolibrary.org/obo/GO_0050855 GO:1902605 biolink:BiologicalProcess heterotrimeric G-protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex. go.json heterotrimeric G-protein GTPase activity assembly|heterotrimeric G-protein GTPase activity formation|heterotrimeric G-protein GTPase, alpha-subunit assembly|heterotrimeric G-protein GTPase, alpha-subunit formation|heterotrimeric G-protein GTPase, beta-subunit assembly|heterotrimeric G-protein GTPase, beta-subunit formation|heterotrimeric G-protein GTPase, gamma-subunit assembly|heterotrimeric G-protein GTPase, gamma-subunit formation|heterotrimeric G-protein complex formation http://purl.obolibrary.org/obo/GO_1902605 GO:0050856 biolink:BiologicalProcess regulation of T cell receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. go.json regulation of T lymphocyte receptor signaling pathway|regulation of T lymphocyte receptor signalling pathway|regulation of T-cell receptor signaling pathway|regulation of T-cell receptor signalling pathway|regulation of T-lymphocyte receptor signaling pathway|regulation of T-lymphocyte receptor signalling pathway|regulation of TCR signaling pathway http://purl.obolibrary.org/obo/GO_0050856 GO:1902606 biolink:BiologicalProcess regulation of large conductance calcium-activated potassium channel activity Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity. go.json regulation of BK KCa channels|regulation of BK calcium-activated potassium channel activity|regulation of BK channel activity|regulation of large conductance KCa channels http://purl.obolibrary.org/obo/GO_1902606 gocheck_do_not_annotate GO:0050853 biolink:BiologicalProcess B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. go.json B cell receptor signalling pathway|B lymphocyte receptor signaling pathway|B lymphocyte receptor signalling pathway|B-cell receptor signaling pathway|B-cell receptor signalling pathway|B-lymphocyte receptor signaling pathway|B-lymphocyte receptor signalling pathway http://purl.obolibrary.org/obo/GO_0050853 GO:1902603 biolink:BiologicalProcess carnitine transmembrane transport The directed movement of carnitine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1902603 GO:0050854 biolink:BiologicalProcess regulation of antigen receptor-mediated signaling pathway Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. go.json regulation of antigen receptor mediated signalling pathway http://purl.obolibrary.org/obo/GO_0050854 GO:1902604 biolink:BiologicalProcess p-aminobenzoyl-glutamate transmembrane transport The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane. go.json N-(4-aminobenzoyl)-L-glutamate transmembrane transport http://purl.obolibrary.org/obo/GO_1902604 GO:1902601 biolink:BiologicalProcess silver ion transmembrane transport The directed movement of silver ion across a membrane. go.json silver transmembrane transport http://purl.obolibrary.org/obo/GO_1902601 GO:0050859 biolink:BiologicalProcess negative regulation of B cell receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. go.json down regulation of B cell receptor signaling pathway|down-regulation of B cell receptor signaling pathway|downregulation of B cell receptor signaling pathway|inhibition of B cell receptor signaling pathway|negative regulation of B cell receptor signalling pathway|negative regulation of B lymphocyte receptor signaling pathway|negative regulation of B lymphocyte receptor signalling pathway|negative regulation of B-cell receptor signaling pathway|negative regulation of B-cell receptor signalling pathway|negative regulation of B-lymphocyte receptor signaling pathway|negative regulation of B-lymphocyte receptor signalling pathway http://purl.obolibrary.org/obo/GO_0050859 GO:1902602 biolink:BiologicalProcess aluminum ion transmembrane transport The process in which an aluminium ion is transported across a membrane. go.json aluminium ion transmembrane transport|aluminium transmembrane transport|aluminum transmembrane transport http://purl.obolibrary.org/obo/GO_1902602 GO:0050857 biolink:BiologicalProcess positive regulation of antigen receptor-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. go.json activation of antigen receptor-mediated signaling pathway|positive regulation of antigen receptor mediated signalling pathway|stimulation of antigen receptor-mediated signaling pathway|up regulation of antigen receptor-mediated signaling pathway|up-regulation of antigen receptor-mediated signaling pathway|upregulation of antigen receptor-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0050857 GO:1902600 biolink:BiologicalProcess proton transmembrane transport The directed movement of a proton across a membrane. go.json ATP hydrolysis coupled proton transport|hydrogen ion transmembrane transport|hydrogen ion transport|hydrogen transmembrane transport|hydrogen transport|passive proton transport, down the electrochemical gradient|proton transport http://purl.obolibrary.org/obo/GO_1902600 goslim_pir GO:0050858 biolink:BiologicalProcess negative regulation of antigen receptor-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. go.json down regulation of antigen receptor-mediated signaling pathway|down-regulation of antigen receptor-mediated signaling pathway|downregulation of antigen receptor-mediated signaling pathway|inhibition of antigen receptor-mediated signaling pathway|negative regulation of antigen receptor mediated signalling pathway http://purl.obolibrary.org/obo/GO_0050858 GO:0050862 biolink:BiologicalProcess positive regulation of T cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. go.json activation of T cell receptor signaling pathway|positive regulation of T cell receptor signalling pathway|positive regulation of T lymphocyte receptor signaling pathway|positive regulation of T lymphocyte receptor signalling pathway|positive regulation of T-cell receptor signaling pathway|positive regulation of T-lymphocyte receptor signaling pathway|positive regulation of T-lymphocyte receptor signalling pathway|positive regulation of TCR signaling pathway|stimulation of T cell receptor signaling pathway|up regulation of T cell receptor signaling pathway|up-regulation of T cell receptor signaling pathway|upregulation of T cell receptor signaling pathway http://purl.obolibrary.org/obo/GO_0050862 GO:0050863 biolink:BiologicalProcess regulation of T cell activation Any process that modulates the frequency, rate or extent of T cell activation. go.json regulation of T lymphocyte activation|regulation of T-cell activation|regulation of T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0050863 GO:0050860 biolink:BiologicalProcess negative regulation of T cell receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. go.json down regulation of T cell receptor signaling pathway|down-regulation of T cell receptor signaling pathway|downregulation of T cell receptor signaling pathway|inhibition of T cell receptor signaling pathway|negative regulation of T cell receptor signalling pathway|negative regulation of T lymphocyte receptor signaling pathway|negative regulation of T lymphocyte receptor signalling pathway|negative regulation of T-cell receptor signaling pathway|negative regulation of T-lymphocyte receptor signaling pathway|negative regulation of T-lymphocyte receptor signalling pathway|negative regulation of TCR signaling pathway http://purl.obolibrary.org/obo/GO_0050860 GO:1902618 biolink:BiologicalProcess cellular response to fluoride Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus. go.json http://purl.obolibrary.org/obo/GO_1902618 GO:0050861 biolink:BiologicalProcess positive regulation of B cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. go.json activation of B cell receptor signaling pathway|positive regulation of B cell receptor signalling pathway|positive regulation of B lymphocyte receptor signaling pathway|positive regulation of B lymphocyte receptor signalling pathway|positive regulation of B-cell receptor signaling pathway|positive regulation of B-cell receptor signalling pathway|positive regulation of B-lymphocyte receptor signaling pathway|positive regulation of B-lymphocyte receptor signalling pathway|stimulation of B cell receptor signaling pathway|up regulation of B cell receptor signaling pathway|up-regulation of B cell receptor signaling pathway|upregulation of B cell receptor signaling pathway http://purl.obolibrary.org/obo/GO_0050861 GO:1902619 biolink:BiologicalProcess regulation of microtubule minus-end binding Any process that modulates the frequency, rate or extent of microtubule minus-end binding. go.json http://purl.obolibrary.org/obo/GO_1902619 gocheck_do_not_annotate GO:1902616 biolink:BiologicalProcess acyl carnitine transmembrane transport The process in which acyl carnitine is transported across a membrane. go.json O-acylcarnitine transmembrane transport http://purl.obolibrary.org/obo/GO_1902616 GO:0050866 biolink:BiologicalProcess negative regulation of cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. go.json down regulation of cell activation|down-regulation of cell activation|downregulation of cell activation|inhibition of cell activation http://purl.obolibrary.org/obo/GO_0050866 GO:0050867 biolink:BiologicalProcess positive regulation of cell activation Any process that activates or increases the frequency, rate or extent of activation. go.json activation of cell activation|stimulation of cell activation|up regulation of cell activation|up-regulation of cell activation|upregulation of cell activation http://purl.obolibrary.org/obo/GO_0050867 GO:1902617 biolink:BiologicalProcess response to fluoride Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus. go.json http://purl.obolibrary.org/obo/GO_1902617 GO:1902614 biolink:BiologicalProcess positive regulation of anti-Mullerian hormone signaling pathway Any process that activates or increases the frequency, rate or extent of anti-Mullerian hormone signaling pathway. go.json activation of anti-Mullerian hormone signaling pathway|up regulation of anti-Mullerian hormone signaling pathway|up-regulation of anti-Mullerian hormone signaling pathway|upregulation of anti-Mullerian hormone signaling pathway http://purl.obolibrary.org/obo/GO_1902614 GO:0050864 biolink:BiologicalProcess regulation of B cell activation Any process that modulates the frequency, rate or extent of B cell activation. go.json regulation of B lymphocyte activation|regulation of B-cell activation|regulation of B-lymphocyte activation http://purl.obolibrary.org/obo/GO_0050864 GO:1902615 biolink:BiologicalProcess immune response involved in response to exogenous dsRNA Any immune response that is involved in response to exogenous dsRNA. go.json immune response involved in response to exogenous double-stranded RNA|immune response involved in response to viral dsRNA http://purl.obolibrary.org/obo/GO_1902615 GO:0050865 biolink:BiologicalProcess regulation of cell activation Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. go.json http://purl.obolibrary.org/obo/GO_0050865 GO:1902612 biolink:BiologicalProcess regulation of anti-Mullerian hormone signaling pathway Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway. go.json http://purl.obolibrary.org/obo/GO_1902612 GO:2001237 biolink:BiologicalProcess negative regulation of extrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. go.json negative regulation of extrinsic apoptosis|negative regulation of extrinsic apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_2001237 GO:1902613 biolink:BiologicalProcess negative regulation of anti-Mullerian hormone signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway. go.json down regulation of anti-Mullerian hormone signaling pathway|down-regulation of anti-Mullerian hormone signaling pathway|downregulation of anti-Mullerian hormone signaling pathway|inhibition of anti-Mullerian hormone signaling pathway http://purl.obolibrary.org/obo/GO_1902613 GO:2001238 biolink:BiologicalProcess positive regulation of extrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. go.json positive regulation of extrinsic apoptosis|positive regulation of extrinsic apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_2001238 GO:2001239 biolink:BiologicalProcess regulation of extrinsic apoptotic signaling pathway in absence of ligand Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. go.json regulation of dependence receptor signaling pathway|regulation of extrinsic apoptosis in absence of ligand|regulation of extrinsic apoptotic signalling pathway in absence of ligand http://purl.obolibrary.org/obo/GO_2001239 GO:0050868 biolink:BiologicalProcess negative regulation of T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. go.json down regulation of T cell activation|down-regulation of T cell activation|downregulation of T cell activation|inhibition of T cell activation|negative regulation of T lymphocyte activation|negative regulation of T-cell activation|negative regulation of T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0050868 GO:1902610 biolink:BiologicalProcess response to N-phenylthiourea Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus. go.json http://purl.obolibrary.org/obo/GO_1902610 GO:0050869 biolink:BiologicalProcess negative regulation of B cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. go.json down regulation of B cell activation|down-regulation of B cell activation|downregulation of B cell activation|inhibition of B cell activation|negative regulation of B lymphocyte activation|negative regulation of B-cell activation|negative regulation of B-lymphocyte activation http://purl.obolibrary.org/obo/GO_0050869 GO:1902611 biolink:BiologicalProcess cellular response to N-phenylthiourea Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus. go.json http://purl.obolibrary.org/obo/GO_1902611 GO:2001230 biolink:BiologicalProcess positive regulation of response to gamma radiation Any process that activates or increases the frequency, rate or extent of response to gamma radiation. go.json positive regulation of response to gamma ray|positive regulation of response to gamma-ray photon http://purl.obolibrary.org/obo/GO_2001230 GO:2001231 biolink:BiologicalProcess regulation of protein localization to prospore membrane Any process that modulates the frequency, rate or extent of protein localization to prospore membrane. go.json regulation of protein localisation to prospore membrane|regulation of protein targeting to FSM|regulation of protein targeting to ascospore-type prospore membrane|regulation of protein targeting to forespore membrane|regulation of protein targeting to prospore membrane|regulation of protein-prospore membrane targeting http://purl.obolibrary.org/obo/GO_2001231 GO:2001232 biolink:BiologicalProcess positive regulation of protein localization to prospore membrane Any process that activates or increases the frequency, rate or extent of protein localization to prospore membrane. go.json positive regulation of protein localisation to prospore membrane|positive regulation of protein targeting to FSM|positive regulation of protein targeting to ascospore-type prospore membrane|positive regulation of protein targeting to forespore membrane|positive regulation of protein targeting to prospore membrane|positive regulation of protein-prospore membrane targeting http://purl.obolibrary.org/obo/GO_2001232 GO:0098808 biolink:MolecularActivity mRNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0098808 GO:2001233 biolink:BiologicalProcess regulation of apoptotic signaling pathway Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. go.json regulation of apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_2001233 GO:2001234 biolink:BiologicalProcess negative regulation of apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. go.json negative regulation of apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_2001234 GO:0098809 biolink:MolecularActivity nitrite reductase activity Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. go.json http://purl.obolibrary.org/obo/GO_0098809 GO:0098806 biolink:BiologicalProcess obsolete miRNA-mediated gene silencing by mRNA deadenylation OBSOLETE. An RNA interference pathway in which a miRNA binding to mRNA triggers shortening of the poly(A) tail of a nuclear-transcribed mRNA, resulting in destabilization of the mRNA and a reduction the amount of translated transcript. go.json deadenylation involved in gene silencing by miRNA|mRNA deadenylation-mediated gene silencing by miRNA True http://purl.obolibrary.org/obo/GO_0098806 GO:2001235 biolink:BiologicalProcess positive regulation of apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. go.json positive regulation of apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_2001235 GO:2001236 biolink:BiologicalProcess regulation of extrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. go.json regulation of extrinsic apoptosis|regulation of extrinsic apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_2001236 GO:0098807 biolink:CellularComponent chloroplast thylakoid membrane protein complex A protein complex that is part of a chloroplast thylakoid membrane. go.json http://purl.obolibrary.org/obo/GO_0098807 GO:0098804 biolink:CellularComponent non-motile cilium membrane The portion of the plasma membrane surrounding a non-motile cilium. go.json nonmotile primary cilium membrane http://purl.obolibrary.org/obo/GO_0098804 GO:0098805 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0098805 GO:0098802 biolink:CellularComponent plasma membrane signaling receptor complex Any protein complex that is part of the plasma membrane and which functions as a signaling receptor. go.json http://purl.obolibrary.org/obo/GO_0098802 gocheck_do_not_manually_annotate GO:0098803 biolink:CellularComponent respiratory chain complex Any protein complex that is part of a respiratory chain. go.json http://purl.obolibrary.org/obo/GO_0098803 GO:0098800 biolink:CellularComponent inner mitochondrial membrane protein complex Any protein complex that is part of the inner mitochondrial membrane. go.json http://purl.obolibrary.org/obo/GO_0098800 GO:0098801 biolink:BiologicalProcess regulation of renal system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. go.json http://purl.obolibrary.org/obo/GO_0098801 GO:0050873 biolink:BiologicalProcess brown fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. go.json brown adipocyte cell differentiation|brown adipocyte differentiation http://purl.obolibrary.org/obo/GO_0050873 GO:0050874 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050874 GO:1902629 biolink:BiologicalProcess regulation of mRNA stability involved in cellular response to UV Any regulation of mRNA stability that is involved in cellular response to UV. go.json regulation of mRNA stability involved in cellular response to UV light stimulus|regulation of mRNA stability involved in cellular response to UV radiation stimulus|regulation of mRNA stability involved in cellular response to ultraviolet light stimulus|regulation of mRNA stability involved in cellular response to ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_1902629 GO:0050871 biolink:BiologicalProcess positive regulation of B cell activation Any process that activates or increases the frequency, rate or extent of B cell activation. go.json activation of B cell activation|positive regulation of B lymphocyte activation|positive regulation of B-cell activation|positive regulation of B-lymphocyte activation|stimulation of B cell activation|up regulation of B cell activation|up-regulation of B cell activation|upregulation of B cell activation http://purl.obolibrary.org/obo/GO_0050871 GO:0050872 biolink:BiologicalProcess white fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. go.json white adipocyte cell differentiation|white adipocyte differentiation http://purl.obolibrary.org/obo/GO_0050872 GO:1902627 biolink:BiologicalProcess regulation of assembly of large subunit precursor of preribosome Any process that modulates the frequency, rate or extent of assembly of a large subunit precursor of preribosome. go.json regulation of 66S preribosome assembly|regulation of 66S preribosome formation|regulation of preribosome, large subunit precursor formation http://purl.obolibrary.org/obo/GO_1902627 GO:0050877 biolink:BiologicalProcess nervous system process A organ system process carried out by any of the organs or tissues of neurological system. go.json neurological system process|neurophysiological process|pan-neural process http://purl.obolibrary.org/obo/GO_0050877 goslim_agr|goslim_chembl|goslim_flybase_ribbon|goslim_generic|goslim_pir GO:1902628 biolink:BiologicalProcess positive regulation of assembly of large subunit precursor of preribosome Any process that activates or increases the frequency, rate or extent of assembly of a large subunit precursor of preribosome. go.json activation of 66S preribosome assembly|activation of 66S preribosome formation|activation of assembly of large subunit precursor of preribosome|activation of preribosome, large subunit precursor formation|positive regulation of 66S preribosome assembly|positive regulation of 66S preribosome formation|positive regulation of preribosome, large subunit precursor formation|up regulation of 66S preribosome assembly|up regulation of 66S preribosome formation|up regulation of assembly of large subunit precursor of preribosome|up regulation of preribosome, large subunit precursor formation|up-regulation of 66S preribosome assembly|up-regulation of 66S preribosome formation|up-regulation of assembly of large subunit precursor of preribosome|up-regulation of preribosome, large subunit precursor formation|upregulation of 66S preribosome assembly|upregulation of 66S preribosome formation|upregulation of assembly of large subunit precursor of preribosome|upregulation of preribosome, large subunit precursor formation http://purl.obolibrary.org/obo/GO_1902628 GO:0050878 biolink:BiologicalProcess regulation of body fluid levels Any process that modulates the levels of body fluids. go.json http://purl.obolibrary.org/obo/GO_0050878 goslim_pir GO:0050875 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050875 GO:1902625 biolink:BiologicalProcess obsolete negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion. go.json True http://purl.obolibrary.org/obo/GO_1902625 GO:1902626 biolink:BiologicalProcess assembly of large subunit precursor of preribosome The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome. go.json 66S preribosome assembly|66S preribosome formation|preribosome, large subunit precursor formation http://purl.obolibrary.org/obo/GO_1902626 GO:0050876 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050876 GO:2001248 biolink:BiologicalProcess regulation of ammonia assimilation cycle Any process that modulates the frequency, rate or extent of ammonia assimilation cycle. go.json regulation of glutamate metabolic process via glutamine and ammonia|regulation of glutamate metabolism via glutamine and ammonia http://purl.obolibrary.org/obo/GO_2001248 GO:1902623 biolink:BiologicalProcess negative regulation of neutrophil migration Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration. go.json down regulation of neutrophil migration|down-regulation of neutrophil migration|downregulation of neutrophil migration|inhibition of neutrophil migration http://purl.obolibrary.org/obo/GO_1902623 GO:2001249 biolink:BiologicalProcess negative regulation of ammonia assimilation cycle Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle. go.json negative regulation of glutamate metabolic process via glutamine and ammonia|negative regulation of glutamate metabolism via glutamine and ammonia http://purl.obolibrary.org/obo/GO_2001249 GO:1902624 biolink:BiologicalProcess positive regulation of neutrophil migration Any process that activates or increases the frequency, rate or extent of neutrophil migration. go.json activation of neutrophil migration|up regulation of neutrophil migration|up-regulation of neutrophil migration|upregulation of neutrophil migration http://purl.obolibrary.org/obo/GO_1902624 GO:0050879 biolink:BiologicalProcess multicellular organismal movement Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0050879 goslim_pir GO:1902621 biolink:BiologicalProcess actomyosin contractile ring disassembly The disaggregation of an actomyosin contractile ring into its constituent components. go.json CAR disassembly|actomyosin ring disassembly|constriction ring disassembly|contractile actomyosin ring disassembly|cytokinetic ring disassembly http://purl.obolibrary.org/obo/GO_1902621 GO:1902622 biolink:BiologicalProcess regulation of neutrophil migration Any process that modulates the frequency, rate or extent of neutrophil migration. go.json http://purl.obolibrary.org/obo/GO_1902622 GO:1902620 biolink:BiologicalProcess positive regulation of microtubule minus-end binding Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding. go.json activation of microtubule minus-end binding|up regulation of microtubule minus-end binding|up-regulation of microtubule minus-end binding|upregulation of microtubule minus-end binding http://purl.obolibrary.org/obo/GO_1902620 gocheck_do_not_annotate GO:2001240 biolink:BiologicalProcess negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. go.json negative regulation of dependence receptor signaling pathway|negative regulation of extrinsic apoptosis in absence of ligand|negative regulation of extrinsic apoptotic signalling pathway in absence of ligand http://purl.obolibrary.org/obo/GO_2001240 GO:0035298 biolink:BiologicalProcess regulation of Malpighian tubule size Ensuring that a Malpighian tubule is the correct length and diameter. go.json http://purl.obolibrary.org/obo/GO_0035298 GO:2001241 biolink:BiologicalProcess positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. go.json positive regulation of dependence receptor signaling pathway|positive regulation of extrinsic apoptosis in absence of ligand|positive regulation of extrinsic apoptotic signalling pathway in absence of ligand http://purl.obolibrary.org/obo/GO_2001241 GO:0035299 biolink:MolecularActivity inositol pentakisphosphate 2-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+. EC:2.7.1.158|KEGG_REACTION:R05202|MetaCyc:RXN-7163|RHEA:20313|Reactome:R-HSA-1855176|Reactome:R-HSA-1855179 go.json ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity|Gsl1p|IP5 2-kinase activity|Ins(1,3,4,5,6)P5 2-kinase activity|Ipk1p|inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity|inositol hexakisphosphate synthase|inositol polyphosphate kinase activity|inositol-pentakisphosphate 2-kinase activity http://purl.obolibrary.org/obo/GO_0035299 GO:2001242 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. go.json regulation of intrinsic apoptosis|regulation of intrinsic apoptotic pathway|regulation of intrinsic apoptotic signalling pathway|regulation of mitochondrial-mediated apoptotic pathway http://purl.obolibrary.org/obo/GO_2001242 GO:2001243 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. go.json negative regulation of intrinsic apoptosis|negative regulation of intrinsic apoptotic pathway|negative regulation of intrinsic apoptotic signalling pathway|negative regulation of mitochondrial-mediated apoptotic pathway http://purl.obolibrary.org/obo/GO_2001243 GO:2001244 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. go.json positive regulation of intrinsic apoptosis|positive regulation of intrinsic apoptotic pathway|positive regulation of intrinsic apoptotic signalling pathway|positive regulation of mitochondrial-mediated apoptotic pathway http://purl.obolibrary.org/obo/GO_2001244 GO:0098819 biolink:BiologicalProcess depolarization of postsynaptic membrane A process that depolarizes a postsynaptic membrane relative to its resting potential. This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold. go.json http://purl.obolibrary.org/obo/GO_0098819 GO:2001245 biolink:BiologicalProcess regulation of phosphatidylcholine biosynthetic process Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process. go.json regulation of phosphatidylcholine anabolism|regulation of phosphatidylcholine biosynthesis|regulation of phosphatidylcholine formation|regulation of phosphatidylcholine synthesis http://purl.obolibrary.org/obo/GO_2001245 GO:2001246 biolink:BiologicalProcess negative regulation of phosphatidylcholine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process. go.json negative regulation of phosphatidylcholine anabolism|negative regulation of phosphatidylcholine biosynthesis|negative regulation of phosphatidylcholine formation|negative regulation of phosphatidylcholine synthesis http://purl.obolibrary.org/obo/GO_2001246 GO:0098817 biolink:BiologicalProcess evoked excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse. go.json http://purl.obolibrary.org/obo/GO_0098817 GO:2001247 biolink:BiologicalProcess positive regulation of phosphatidylcholine biosynthetic process Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process. go.json positive regulation of phosphatidylcholine anabolism|positive regulation of phosphatidylcholine biosynthesis|positive regulation of phosphatidylcholine formation|positive regulation of phosphatidylcholine synthesis http://purl.obolibrary.org/obo/GO_2001247 GO:0098818 biolink:BiologicalProcess hyperpolarization of postsynaptic membrane A process that hyerpolarizes a postsynaptic membrane relative to its resting potential. This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold. go.json http://purl.obolibrary.org/obo/GO_0098818 GO:0035290 biolink:BiologicalProcess trunk segmentation Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. go.json http://purl.obolibrary.org/obo/GO_0035290 GO:0098815 biolink:BiologicalProcess modulation of excitatory postsynaptic potential Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. go.json http://purl.obolibrary.org/obo/GO_0098815 GO:0035291 biolink:BiologicalProcess specification of segmental identity, intercalary segment The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0035291 GO:0098816 biolink:BiologicalProcess mini excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. go.json http://purl.obolibrary.org/obo/GO_0098816 GO:0035292 biolink:BiologicalProcess specification of segmental identity, trunk The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0035292 GO:0098813 biolink:BiologicalProcess nuclear chromosome segregation The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. go.json http://purl.obolibrary.org/obo/GO_0098813 GO:0035293 biolink:BiologicalProcess chitin-based larval cuticle pattern formation The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0035293 GO:0098814 biolink:BiologicalProcess spontaneous synaptic transmission The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential. go.json basal synaptic transmission http://purl.obolibrary.org/obo/GO_0098814 goslim_synapse GO:0098811 biolink:MolecularActivity obsolete transcriptional repressor activity, RNA polymerase II activating transcription factor binding OBSOLETE. Binding to an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. go.json RNA polymerase II activating transcription factor binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II activating transcription factor binding transcription repressor activity|RNA polymerase II transcription repressor activity True http://purl.obolibrary.org/obo/GO_0098811 GO:0035294 biolink:BiologicalProcess determination of wing disc primordium Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc. go.json http://purl.obolibrary.org/obo/GO_0035294 GO:0050870 biolink:BiologicalProcess positive regulation of T cell activation Any process that activates or increases the frequency, rate or extent of T cell activation. go.json activation of T cell activation|positive regulation of T lymphocyte activation|positive regulation of T-cell activation|positive regulation of T-lymphocyte activation|stimulation of T cell activation|up regulation of T cell activation|up-regulation of T cell activation|upregulation of T cell activation http://purl.obolibrary.org/obo/GO_0050870 GO:0098812 biolink:BiologicalProcess obsolete nuclear rRNA polyadenylation involved in polyadenylation-dependent rRNA catabolic process OBSOLETE. The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a rRNA, occurring as part of the process of polyadenylation-dependent rRNA catabolism in the nucleus. go.json nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process|nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process True http://purl.obolibrary.org/obo/GO_0098812 GO:0035295 biolink:BiologicalProcess tube development The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. go.json http://purl.obolibrary.org/obo/GO_0035295 GO:0035296 biolink:BiologicalProcess regulation of tube diameter Any process that modulates the diameter of a tube. go.json http://purl.obolibrary.org/obo/GO_0035296 GO:0035297 biolink:BiologicalProcess regulation of Malpighian tubule diameter Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells. go.json http://purl.obolibrary.org/obo/GO_0035297 GO:0098810 biolink:BiologicalProcess neurotransmitter reuptake The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. go.json http://purl.obolibrary.org/obo/GO_0098810 goslim_synapse GO:0050884 biolink:BiologicalProcess neuromuscular process controlling posture Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. go.json regulation of posture http://purl.obolibrary.org/obo/GO_0050884 GO:0050885 biolink:BiologicalProcess neuromuscular process controlling balance Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. go.json regulation of balance http://purl.obolibrary.org/obo/GO_0050885 GO:0050882 biolink:BiologicalProcess voluntary musculoskeletal movement The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will. go.json http://purl.obolibrary.org/obo/GO_0050882 GO:0050883 biolink:BiologicalProcess musculoskeletal movement, spinal reflex action Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0050883 GO:1902638 biolink:BiologicalProcess neural crest cell differentiation involved in parathyroid gland development Any neural crest cell differentiation that is involved in parathyroid gland development. go.json http://purl.obolibrary.org/obo/GO_1902638 GO:0050888 biolink:BiologicalProcess determination of stimulus location The determination of where on the body surface, within the body or in the environment a stimulus originates. go.json http://purl.obolibrary.org/obo/GO_0050888 GO:1902639 biolink:BiologicalProcess propan-2-ol metabolic process The chemical reactions and pathways involving propan-2-ol. go.json Isopropanol metabolic process|Isopropyl alcohol metabolic process|propan-2-ol metabolism http://purl.obolibrary.org/obo/GO_1902639 GO:0050889 biolink:BiologicalProcess determination of stimulus intensity The determination of the perceived strength of a sensory stimulus. go.json http://purl.obolibrary.org/obo/GO_0050889 GO:1902636 biolink:CellularComponent kinociliary basal body A ciliary basal body that is part of a kinocilium. go.json cilial basal body of kinocilium|ciliary basal body of kinocilium|cilium basal body of kinocilium|kinocilial basal body|kinocilium basal body|kinocilium ciliary basal body|microtubule basal body of kinocilium http://purl.obolibrary.org/obo/GO_1902636 GO:0050886 biolink:BiologicalProcess endocrine process The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. go.json endocrine physiological process|endocrine physiology http://purl.obolibrary.org/obo/GO_0050886 goslim_generic|goslim_pir GO:1902637 biolink:BiologicalProcess neural crest cell differentiation involved in thymus development Any neural crest cell differentiation that is involved in thymus development. go.json http://purl.obolibrary.org/obo/GO_1902637 GO:0050887 biolink:BiologicalProcess determination of sensory modality The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain. go.json http://purl.obolibrary.org/obo/GO_0050887 GO:1902634 biolink:BiologicalProcess 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. go.json 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation http://purl.obolibrary.org/obo/GO_1902634 GO:2001259 biolink:BiologicalProcess positive regulation of cation channel activity Any process that activates or increases the frequency, rate or extent of cation channel activity. go.json positive regulation of cation diffusion facilitator activity|positive regulation of nonselective cation channel activity http://purl.obolibrary.org/obo/GO_2001259 gocheck_do_not_annotate GO:1902635 biolink:BiologicalProcess 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. go.json 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis http://purl.obolibrary.org/obo/GO_1902635 GO:1902632 biolink:BiologicalProcess positive regulation of membrane hyperpolarization Any process that activates or increases the frequency, rate or extent of membrane hyperpolarization. go.json activation of membrane hyperpolarization|up regulation of membrane hyperpolarization|up-regulation of membrane hyperpolarization|upregulation of membrane hyperpolarization http://purl.obolibrary.org/obo/GO_1902632 GO:1902633 biolink:BiologicalProcess 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. go.json 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolism http://purl.obolibrary.org/obo/GO_1902633 GO:1902630 biolink:BiologicalProcess regulation of membrane hyperpolarization Any process that modulates the frequency, rate or extent of membrane hyperpolarization. go.json http://purl.obolibrary.org/obo/GO_1902630 GO:1902631 biolink:BiologicalProcess negative regulation of membrane hyperpolarization Any process that stops, prevents or reduces the frequency, rate or extent of membrane hyperpolarization. go.json down regulation of membrane hyperpolarization|down-regulation of membrane hyperpolarization|downregulation of membrane hyperpolarization|inhibition of membrane hyperpolarization http://purl.obolibrary.org/obo/GO_1902631 GO:2001251 biolink:BiologicalProcess negative regulation of chromosome organization Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. go.json negative regulation of chromosome organisation|negative regulation of chromosome organization and biogenesis|negative regulation of maintenance of genome integrity|negative regulation of nuclear genome maintenance http://purl.obolibrary.org/obo/GO_2001251 GO:0060210 biolink:BiologicalProcess metestrus The estrous cycle phase in which there is subsiding follicular function. go.json http://purl.obolibrary.org/obo/GO_0060210 gocheck_do_not_annotate GO:0035287 biolink:BiologicalProcess head segmentation Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial). go.json http://purl.obolibrary.org/obo/GO_0035287 GO:2001252 biolink:BiologicalProcess positive regulation of chromosome organization Any process that activates or increases the frequency, rate or extent of chromosome organization. go.json positive regulation of chromosome organisation|positive regulation of chromosome organization and biogenesis|positive regulation of maintenance of genome integrity|positive regulation of nuclear genome maintenance http://purl.obolibrary.org/obo/GO_2001252 GO:0035288 biolink:BiologicalProcess anterior head segmentation Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments. go.json procephalic segmentation http://purl.obolibrary.org/obo/GO_0035288 GO:0060211 biolink:BiologicalProcess regulation of nuclear-transcribed mRNA poly(A) tail shortening Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. go.json regulation of 3' to 5' mRNA deadenylation|regulation of mRNA deadenylation|regulation of nuclear mRNA poly(A) tail shortening http://purl.obolibrary.org/obo/GO_0060211 GO:2001253 biolink:BiologicalProcess obsolete regulation of histone H3-K36 trimethylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation. go.json True http://purl.obolibrary.org/obo/GO_2001253 GO:0035289 biolink:BiologicalProcess posterior head segmentation Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains. go.json gnathal segmentation http://purl.obolibrary.org/obo/GO_0035289 GO:0060212 biolink:BiologicalProcess negative regulation of nuclear-transcribed mRNA poly(A) tail shortening Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. go.json negative regulation of 3' to 5' mRNA deadenylation|negative regulation of mRNA deadenylation|negative regulation of nuclear mRNA poly(A) tail shortening http://purl.obolibrary.org/obo/GO_0060212 GO:2001254 biolink:BiologicalProcess obsolete negative regulation of histone H3-K36 trimethylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation. go.json True http://purl.obolibrary.org/obo/GO_2001254 GO:0060213 biolink:BiologicalProcess positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. go.json positive regulation of 3' to 5' mRNA deadenylation|positive regulation of mRNA deadenylation|positive regulation of nuclear mRNA poly(A) tail shortening http://purl.obolibrary.org/obo/GO_0060213 GO:2001255 biolink:BiologicalProcess obsolete positive regulation of histone H3-K36 trimethylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation. go.json True http://purl.obolibrary.org/obo/GO_2001255 GO:0060214 biolink:BiologicalProcess endocardium formation Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. go.json http://purl.obolibrary.org/obo/GO_0060214 GO:2001256 biolink:BiologicalProcess regulation of store-operated calcium entry Any process that modulates the frequency, rate or extent of store-operated calcium entry. go.json regulation of SOCE|regulation of calcium ion import|regulation of capacitative calcium entry|regulation of store-operated calcium import http://purl.obolibrary.org/obo/GO_2001256 GO:0060215 biolink:BiologicalProcess primitive hemopoiesis A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells. go.json primitive haematopoiesis|primitive haemopoiesis|primitive hematopoiesis http://purl.obolibrary.org/obo/GO_0060215 GO:2001257 biolink:BiologicalProcess regulation of cation channel activity Any process that modulates the frequency, rate or extent of cation channel activity. go.json regulation of cation diffusion facilitator activity|regulation of nonselective cation channel activity http://purl.obolibrary.org/obo/GO_2001257 gocheck_do_not_annotate GO:0060216 biolink:BiologicalProcess definitive hemopoiesis A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. go.json definitive haematopoiesis|definitive haemopoiesis|definitive hematopoiesis http://purl.obolibrary.org/obo/GO_0060216 GO:2001258 biolink:BiologicalProcess negative regulation of cation channel activity Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. go.json negative regulation of cation diffusion facilitator activity|negative regulation of nonselective cation channel activity http://purl.obolibrary.org/obo/GO_2001258 gocheck_do_not_annotate GO:0060217 biolink:BiologicalProcess hemangioblast cell differentiation The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages. go.json http://purl.obolibrary.org/obo/GO_0060217 GO:0060218 biolink:BiologicalProcess hematopoietic stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. go.json haematopoietic stem cell differentiation|haemopoietic stem cell differentiation|hemopoietic stem cell differentiation http://purl.obolibrary.org/obo/GO_0060218 GO:0060219 biolink:BiologicalProcess camera-type eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0060219 GO:0035280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035280 GO:0035281 biolink:BiologicalProcess pre-miRNA export from nucleus Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product. go.json pre-microRNA export from cell nucleus|pre-microRNA export from nucleus|pre-microRNA export out of nucleus|pre-microRNA transport from nucleus to cytoplasm|pre-microRNA-nucleus export http://purl.obolibrary.org/obo/GO_0035281 GO:0035282 biolink:BiologicalProcess segmentation The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. Wikipedia:Segmentation_(biology) go.json http://purl.obolibrary.org/obo/GO_0035282 GO:0035283 biolink:BiologicalProcess central nervous system segmentation Division of the central nervous system into a series of semi-repetitive parts or segments. go.json http://purl.obolibrary.org/obo/GO_0035283 GO:0050880 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050880 GO:0050881 biolink:BiologicalProcess musculoskeletal movement The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. go.json http://purl.obolibrary.org/obo/GO_0050881 GO:0035284 biolink:BiologicalProcess brain segmentation Division of the brain into a series of semi-repetitive parts or segments. go.json http://purl.obolibrary.org/obo/GO_0035284 GO:0035285 biolink:BiologicalProcess appendage segmentation Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented. go.json http://purl.obolibrary.org/obo/GO_0035285 GO:0035286 biolink:BiologicalProcess obsolete leg segmentation OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint. go.json leg segmentation True http://purl.obolibrary.org/obo/GO_0035286 GO:2001250 biolink:BiologicalProcess positive regulation of ammonia assimilation cycle Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle. go.json positive regulation of glutamate metabolic process via glutamine and ammonia|positive regulation of glutamate metabolism via glutamine and ammonia http://purl.obolibrary.org/obo/GO_2001250 GO:0050895 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0050895 GO:0050896 biolink:BiologicalProcess response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. go.json physiological response to stimulus http://purl.obolibrary.org/obo/GO_0050896 gocheck_do_not_manually_annotate|goslim_agr|goslim_flybase_ribbon|goslim_mouse|goslim_pir|prokaryote_subset GO:0050893 biolink:BiologicalProcess sensory processing Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect. go.json http://purl.obolibrary.org/obo/GO_0050893 GO:0050894 biolink:BiologicalProcess determination of affect Any process in which an emotional response is associated with a particular sensory stimulation. go.json http://purl.obolibrary.org/obo/GO_0050894 GO:1902649 biolink:BiologicalProcess obsolete regulation of histone H2A-H2B dimer displacement OBSOLETE. Any process that modulates the frequency, rate or extent of histone H2A-H2B dimer displacement. go.json True http://purl.obolibrary.org/obo/GO_1902649 GO:0050899 biolink:BiologicalProcess nitrile catabolic process The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. go.json nitrile breakdown|nitrile catabolism|nitrile degradation http://purl.obolibrary.org/obo/GO_0050899 GO:1902647 biolink:BiologicalProcess negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. go.json down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis http://purl.obolibrary.org/obo/GO_1902647 GO:0050897 biolink:MolecularActivity cobalt ion binding Binding to a cobalt ion (Co). go.json Co ion binding|cobalt binding http://purl.obolibrary.org/obo/GO_0050897 GO:1902648 biolink:BiologicalProcess positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. go.json activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis http://purl.obolibrary.org/obo/GO_1902648 GO:0050898 biolink:BiologicalProcess nitrile metabolic process The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile. go.json nitrile metabolism http://purl.obolibrary.org/obo/GO_0050898 GO:1902645 biolink:BiologicalProcess tertiary alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of tertiary alcohol. go.json tertiary alcohol anabolism|tertiary alcohol biosynthesis|tertiary alcohol formation|tertiary alcohol synthesis http://purl.obolibrary.org/obo/GO_1902645 GO:1902646 biolink:BiologicalProcess regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. go.json regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism|regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis|regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation|regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis http://purl.obolibrary.org/obo/GO_1902646 GO:1902643 biolink:BiologicalProcess positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process. go.json activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation http://purl.obolibrary.org/obo/GO_1902643 GO:1902644 biolink:BiologicalProcess tertiary alcohol metabolic process The chemical reactions and pathways involving tertiary alcohol. go.json tertiary alcohol metabolism http://purl.obolibrary.org/obo/GO_1902644 GO:1902641 biolink:BiologicalProcess regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process. go.json regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation http://purl.obolibrary.org/obo/GO_1902641 GO:1902642 biolink:BiologicalProcess negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process. go.json down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism|negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation http://purl.obolibrary.org/obo/GO_1902642 GO:1902640 biolink:BiologicalProcess propan-2-ol biosynthetic process The chemical reactions and pathways resulting in the formation of propan-2-ol. go.json Isopropanol biosynthetic process|Isopropyl alcohol biosynthetic process|propan-2-ol anabolism|propan-2-ol biosynthesis|propan-2-ol formation|propan-2-ol synthesis http://purl.obolibrary.org/obo/GO_1902640 GO:0035276 biolink:MolecularActivity ethanol binding Binding to ethanol, CH(3)-CH(2)-OH. go.json http://purl.obolibrary.org/obo/GO_0035276 GO:2001262 biolink:BiologicalProcess positive regulation of semaphorin-plexin signaling pathway Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway. go.json positive regulation of semaphorin-plexin signalling pathway http://purl.obolibrary.org/obo/GO_2001262 GO:2001263 biolink:BiologicalProcess regulation of C-C chemokine binding Any process that modulates the frequency, rate or extent of C-C chemokine binding. go.json http://purl.obolibrary.org/obo/GO_2001263 gocheck_do_not_annotate GO:0060200 biolink:CellularComponent clathrin-sculpted acetylcholine transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine. go.json clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle|clathrin sculpted acetylcholine transport vesicle http://purl.obolibrary.org/obo/GO_0060200 GO:0035277 biolink:BiologicalProcess spiracle morphogenesis, open tracheal system The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk. go.json spiracle morphogenesis http://purl.obolibrary.org/obo/GO_0035277 GO:0060201 biolink:CellularComponent clathrin-sculpted acetylcholine transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle. go.json clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane|clathrin sculpted acetylcholine transport vesicle membrane http://purl.obolibrary.org/obo/GO_0060201 GO:2001264 biolink:BiologicalProcess negative regulation of C-C chemokine binding Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding. go.json http://purl.obolibrary.org/obo/GO_2001264 gocheck_do_not_annotate GO:0035278 biolink:BiologicalProcess miRNA-mediated gene silencing by inhibition of translation An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. go.json down regulation of translation involved in gene silencing by miRNA|down-regulation of translation involved in gene silencing by miRNA|downregulation of translation involved in gene silencing by miRNA|gene silencing by miRNA, negative regulation of translation|inhibition of translation involved in gene silencing by miRNA|miRNA mediated inhibition of translation|miRNA-mediated gene silencing, negative regulation of translation|negative regulation of translation involved in gene silencing by microRNA http://purl.obolibrary.org/obo/GO_0035278 GO:2001265 biolink:BiologicalProcess positive regulation of C-C chemokine binding Any process that activates or increases the frequency, rate or extent of C-C chemokine binding. go.json http://purl.obolibrary.org/obo/GO_2001265 gocheck_do_not_annotate GO:0060202 biolink:CellularComponent clathrin-sculpted acetylcholine transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle. go.json clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen|clathrin sculpted acetylcholine transport vesicle lumen http://purl.obolibrary.org/obo/GO_0060202 GO:0035279 biolink:BiologicalProcess miRNA-mediated gene silencing by mRNA destabilization An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. go.json deadenylation involved in gene silencing by miRNA|gene silencing by mRNA cleavage|gene silencing by miRNA, mRNA cleavage|mRNA cleavage involved in gene silencing by miRNA|mRNA cleavage involved in gene silencing by microRNA|mRNA deadenylation-mediated gene silencing by miRNA|mRNA destabilization-mediated gene silencing by miRNA|miRNA-mediated gene silencing by mRNA deadenylation|miRNA-mediated gene silencing, mRNA cleavage http://purl.obolibrary.org/obo/GO_0035279 GO:2001266 biolink:BiologicalProcess Roundabout signaling pathway involved in axon guidance Any Roundabout signaling pathway that is involved in axon guidance. go.json ROBO signaling pathway involved in axon chemotaxis|ROBO signaling pathway involved in axon growth cone guidance|ROBO signaling pathway involved in axon guidance|ROBO signaling pathway involved in axon pathfinding|ROBO/SLIT signaling pathway involved in axon chemotaxis|ROBO/SLIT signaling pathway involved in axon growth cone guidance|ROBO/SLIT signaling pathway involved in axon guidance|ROBO/SLIT signaling pathway involved in axon pathfinding|Roundabout signaling pathway involved in axon chemotaxis|Roundabout signaling pathway involved in axon growth cone guidance|Roundabout signaling pathway involved in axon pathfinding|Roundabout signalling pathway involved in axon chemotaxis|Roundabout signalling pathway involved in axon growth cone guidance|Roundabout signalling pathway involved in axon guidance|Roundabout signalling pathway involved in axon pathfinding http://purl.obolibrary.org/obo/GO_2001266 GO:0060203 biolink:CellularComponent clathrin-sculpted glutamate transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle. go.json clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane http://purl.obolibrary.org/obo/GO_0060203 GO:0060204 biolink:CellularComponent clathrin-sculpted glutamate transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle. go.json clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen|clathrin sculpted glutamate transport vesicle lumen http://purl.obolibrary.org/obo/GO_0060204 GO:2001267 biolink:BiologicalProcess regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. go.json regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|regulation of initiator caspase activity http://purl.obolibrary.org/obo/GO_2001267 gocheck_do_not_annotate GO:0060205 biolink:CellularComponent cytoplasmic vesicle lumen The volume enclosed by a cytoplasmic vesicle. go.json cytoplasmic membrane-bounded vesicle lumen|cytoplasmic membrane-enclosed vesicle lumen http://purl.obolibrary.org/obo/GO_0060205 GO:2001268 biolink:BiologicalProcess negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. go.json negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|negative regulation of initiator caspase activity http://purl.obolibrary.org/obo/GO_2001268 gocheck_do_not_annotate GO:2001269 biolink:BiologicalProcess positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. go.json positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|positive regulation of initiator caspase activity http://purl.obolibrary.org/obo/GO_2001269 gocheck_do_not_annotate GO:0060206 biolink:BiologicalProcess estrous cycle phase The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur. go.json http://purl.obolibrary.org/obo/GO_0060206 gocheck_do_not_annotate GO:0060207 biolink:BiologicalProcess diestrus The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum. go.json http://purl.obolibrary.org/obo/GO_0060207 gocheck_do_not_annotate GO:0060208 biolink:BiologicalProcess proestrus The estrous cycle phase in which there is heightened follicular activity. go.json http://purl.obolibrary.org/obo/GO_0060208 gocheck_do_not_annotate GO:0035270 biolink:BiologicalProcess endocrine system development Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. go.json http://purl.obolibrary.org/obo/GO_0035270 GO:0060209 biolink:BiologicalProcess estrus The estrous cycle phase in which a female is sexually receptive. go.json oestrus http://purl.obolibrary.org/obo/GO_0060209 gocheck_do_not_annotate GO:0035271 biolink:BiologicalProcess ring gland development Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones. go.json http://purl.obolibrary.org/obo/GO_0035271 GO:0050891 biolink:BiologicalProcess multicellular organismal-level water homeostasis A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. go.json body fluid osmoregulation|multicellular organismal water homeostasis http://purl.obolibrary.org/obo/GO_0050891 GO:0035272 biolink:BiologicalProcess exocrine system development Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. go.json http://purl.obolibrary.org/obo/GO_0035272 GO:0035273 biolink:MolecularActivity phthalate binding Binding to a phthalate, any ester or salt of phthalic acid. go.json http://purl.obolibrary.org/obo/GO_0035273 goslim_pir GO:0050892 biolink:BiologicalProcess intestinal absorption Any process in which nutrients are taken up from the contents of the intestine. go.json http://purl.obolibrary.org/obo/GO_0050892 GO:0035274 biolink:MolecularActivity diphenyl phthalate binding Binding to diphenyl phthalate, C(20)H(14)O(4). go.json DPP binding http://purl.obolibrary.org/obo/GO_0035274 GO:2001260 biolink:BiologicalProcess regulation of semaphorin-plexin signaling pathway Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway. go.json regulation of semaphorin-plexin signalling pathway http://purl.obolibrary.org/obo/GO_2001260 GO:0035275 biolink:MolecularActivity dibutyl phthalate binding Binding to dibutyl phthalate, C(16)H(22)O(4). go.json DBP binding|phthalic acid dibutyl ester binding http://purl.obolibrary.org/obo/GO_0035275 GO:2001261 biolink:BiologicalProcess negative regulation of semaphorin-plexin signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway. go.json negative regulation of semaphorin-plexin signalling pathway http://purl.obolibrary.org/obo/GO_2001261 GO:0050890 biolink:BiologicalProcess cognition The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. Wikipedia:Cognition go.json http://purl.obolibrary.org/obo/GO_0050890 goslim_drosophila GO:2001075 biolink:BiologicalProcess negative regulation of metanephric ureteric bud development Any process that stops, prevents or reduces the frequency, rate or extent of metanephric ureteric bud development. go.json http://purl.obolibrary.org/obo/GO_2001075 GO:2001076 biolink:BiologicalProcess positive regulation of metanephric ureteric bud development Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development. go.json http://purl.obolibrary.org/obo/GO_2001076 GO:2001077 biolink:MolecularActivity (1->3),(1->4)-beta-glucan binding Binding to (1->3),(1->4)-beta-glucan. go.json (1,3),(1,4)-beta-glucan binding|1->3,1->4-beta-glucan binding|beta-(1,3),(1,4)-glucan binding|beta-(1->3),(1->4)-glucan binding|beta-1,3-1,4-glucan binding|beta-1->3,1->4-glucan binding http://purl.obolibrary.org/obo/GO_2001077 GO:2001078 biolink:MolecularActivity (1->6)-beta-D-glucan binding Binding to (1->6)-beta-D-glucan. go.json (1,6)-beta-D-glucan binding|1,6-beta-D-glucan binding|1->6-beta-D-glucan binding|beta-(1,6)-D-glucan binding|beta-(1->6)-D-glucan binding|beta-1,6-D-glucan binding|beta-1->6-D-glucan binding http://purl.obolibrary.org/obo/GO_2001078 GO:2001079 biolink:MolecularActivity beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc. go.json http://purl.obolibrary.org/obo/GO_2001079 GO:2001070 biolink:MolecularActivity starch binding Binding to starch. go.json amidon binding|amylum binding http://purl.obolibrary.org/obo/GO_2001070 GO:2001071 biolink:MolecularActivity maltoheptaose binding Binding to maltoheptaose. go.json http://purl.obolibrary.org/obo/GO_2001071 GO:2001072 biolink:MolecularActivity galactomannan binding Binding to galactomannan. go.json http://purl.obolibrary.org/obo/GO_2001072 GO:2001073 biolink:MolecularActivity cyclodextrin binding Binding to cyclodextrin. go.json http://purl.obolibrary.org/obo/GO_2001073 GO:2001074 biolink:BiologicalProcess regulation of metanephric ureteric bud development Any process that modulates the frequency, rate or extent of metanephric ureteric bud development. go.json http://purl.obolibrary.org/obo/GO_2001074 GO:2001086 biolink:BiologicalProcess obsolete laminarabiose transport OBSOLETE. The directed movement of a laminarabioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json True http://purl.obolibrary.org/obo/GO_2001086 GO:2001087 biolink:BiologicalProcess sophorose transport The directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001087 GO:2001088 biolink:BiologicalProcess trisaccharide transport The directed movement of a trisaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001088 GO:2001089 biolink:BiologicalProcess maltotriose transport The directed movement of a maltotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001089 GO:2001080 biolink:MolecularActivity chitosan binding Binding to chitosan. go.json http://purl.obolibrary.org/obo/GO_2001080 GO:2001081 biolink:MolecularActivity (1->4)-beta-D-galactan binding Binding to (1->4)-beta-D-galactan. go.json (1,4)-beta-D-galactan binding http://purl.obolibrary.org/obo/GO_2001081 GO:2001082 biolink:MolecularActivity inulin binding Binding to inulin. go.json http://purl.obolibrary.org/obo/GO_2001082 GO:2001083 biolink:MolecularActivity alpha-D-glucan binding Binding to alpha-D-glucan. go.json http://purl.obolibrary.org/obo/GO_2001083 GO:2001084 biolink:MolecularActivity L-arabinofuranose binding Binding to L-arabinofuranose. go.json http://purl.obolibrary.org/obo/GO_2001084 GO:2001085 biolink:MolecularActivity arabinogalactan binding Binding to arabinogalactan. go.json http://purl.obolibrary.org/obo/GO_2001085 GO:2001097 biolink:BiologicalProcess laminaritriose transport The directed movement of a laminaritrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001097 GO:2001098 biolink:BiologicalProcess tetrasaccharide transport The directed movement of a tetrasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001098 GO:2001099 biolink:BiologicalProcess maltotetraose transport The directed movement of a maltotetraoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001099 GO:2001090 biolink:BiologicalProcess maltotriulose transport The directed movement of a maltotriuloseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001090 GO:2001091 biolink:BiologicalProcess nigerotriose transport The directed movement of a nigerotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001091 GO:2001092 biolink:BiologicalProcess arabinotriose transport The directed movement of an arabinotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001092 GO:2001093 biolink:BiologicalProcess galactotriose transport The directed movement of a galactotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001093 GO:2001094 biolink:BiologicalProcess xylotriose transport The directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001094 GO:2001095 biolink:BiologicalProcess mannotriose transport The directed movement of a mannotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001095 GO:2001096 biolink:BiologicalProcess cellotriose transport The directed movement of a cellotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001096 GO:0035427 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035427 GO:0035428 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035428 GO:0035429 biolink:BiologicalProcess gluconate transmembrane transport The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. go.json gluconate membrane transport|gluconate transport http://purl.obolibrary.org/obo/GO_0035429 GO:0035420 biolink:BiologicalProcess obsolete MAPK cascade involved in innate immune response OBSOLETE. A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. go.json MAPKKK cascade involved in innate immune response True http://purl.obolibrary.org/obo/GO_0035420 GO:0035421 biolink:BiologicalProcess obsolete activation of MAPKK activity involved in innate immune response OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. go.json True http://purl.obolibrary.org/obo/GO_0035421 GO:0035422 biolink:BiologicalProcess obsolete activation of MAPKKK activity involved in innate immune response OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. go.json True http://purl.obolibrary.org/obo/GO_0035422 GO:0035423 biolink:BiologicalProcess obsolete inactivation of MAPK activity involved in innate immune response OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. go.json True http://purl.obolibrary.org/obo/GO_0035423 GO:0035424 biolink:BiologicalProcess obsolete MAPK import into nucleus involved in innate immune response OBSOLETE. The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. go.json nuclear translocation of MAPK involved in innate immune response True http://purl.obolibrary.org/obo/GO_0035424 GO:0035425 biolink:BiologicalProcess autocrine signaling Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type. go.json autocrine signalling http://purl.obolibrary.org/obo/GO_0035425 GO:0035426 biolink:BiologicalProcess extracellular matrix-cell signaling Any process that mediates the transfer of information between the extracellular matrix and a cell. go.json cell-extracellular matrix signalling|extracellular matrix-cell signalling http://purl.obolibrary.org/obo/GO_0035426 GO:0035416 biolink:BiologicalProcess obsolete positive regulation of mitotic prometaphase OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. go.json positive regulation of mitotic prometaphase True http://purl.obolibrary.org/obo/GO_0035416 GO:0035417 biolink:BiologicalProcess obsolete negative regulation of mitotic prometaphase OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. go.json negative regulation of mitotic prometaphase True http://purl.obolibrary.org/obo/GO_0035417 GO:0035418 biolink:BiologicalProcess protein localization to synapse Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. go.json protein localisation to synapse http://purl.obolibrary.org/obo/GO_0035418 GO:0035419 biolink:BiologicalProcess obsolete activation of MAPK activity involved in innate immune response OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. go.json True http://purl.obolibrary.org/obo/GO_0035419 GO:0035410 biolink:MolecularActivity dihydrotestosterone 17-beta-dehydrogenase activity Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. EC:1.1.1.51 go.json http://purl.obolibrary.org/obo/GO_0035410 GO:0035411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035411 GO:0035412 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035412 GO:0035413 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035413 GO:0035414 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035414 GO:0035415 biolink:BiologicalProcess obsolete regulation of mitotic prometaphase OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. go.json regulation of mitotic prometaphase True http://purl.obolibrary.org/obo/GO_0035415 GO:0035405 biolink:BiologicalProcess obsolete histone-threonine phosphorylation OBSOLETE. The modification of histones by addition of a phosphate group to a threonine residue. go.json histone threonine phosphorylation True http://purl.obolibrary.org/obo/GO_0035405 GO:0035406 biolink:BiologicalProcess obsolete histone-tyrosine phosphorylation OBSOLETE. The modification of histones by addition of a phosphate group to a tyrosine residue. go.json histone tyrosine phosphorylation True http://purl.obolibrary.org/obo/GO_0035406 GO:0035407 biolink:BiologicalProcess obsolete histone H3-T11 phosphorylation OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone. go.json True http://purl.obolibrary.org/obo/GO_0035407 GO:0035408 biolink:BiologicalProcess obsolete histone H3-T6 phosphorylation OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone. go.json True http://purl.obolibrary.org/obo/GO_0035408 GO:0035409 biolink:BiologicalProcess obsolete histone H3-Y41 phosphorylation OBSOLETE. The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. go.json True http://purl.obolibrary.org/obo/GO_0035409 GO:0035400 biolink:MolecularActivity obsolete histone tyrosine kinase activity OBSOLETE. Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. go.json histone-tyrosine kinase activity True http://purl.obolibrary.org/obo/GO_0035400 GO:0035401 biolink:MolecularActivity histone H3Y41 kinase activity Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3. go.json histone H3-Y41 kinase activity|histone kinase activity (H3-Y41 specific)|histone tyrosine kinase activity (H3-Y41 specific)|histone-tyrosine kinase activity (H3-Y41 specific) http://purl.obolibrary.org/obo/GO_0035401 GO:0035402 biolink:MolecularActivity histone H3T11 kinase activity Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3. go.json histone H3-T11 kinase activity|histone kinase activity (H3-T11 specific)|histone threonine kinase activity (H3-T11 specific)|histone-threonine kinase activity (H3-T11 specific) http://purl.obolibrary.org/obo/GO_0035402 GO:0035403 biolink:MolecularActivity histone H3T6 kinase activity Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3. go.json histone H3-T6 kinase activity|histone kinase activity (H3-T6 specific)|histone threonine kinase activity (H3-T6 specific)|histone-threonine kinase activity (H3-T6 specific) http://purl.obolibrary.org/obo/GO_0035403 GO:0035404 biolink:BiologicalProcess obsolete histone-serine phosphorylation OBSOLETE. The modification of histones by addition of a phosphate group to a serine residue. go.json histone serine phosphorylation True http://purl.obolibrary.org/obo/GO_0035404 GO:0098961 biolink:BiologicalProcess dendritic transport of ribonucleoprotein complex The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites. go.json dendritic transport of RNP complex http://purl.obolibrary.org/obo/GO_0098961 goslim_synapse GO:0098962 biolink:BiologicalProcess regulation of postsynaptic neurotransmitter receptor activity Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. go.json http://purl.obolibrary.org/obo/GO_0098962 gocheck_do_not_annotate|goslim_synapse GO:0098960 biolink:MolecularActivity postsynaptic neurotransmitter receptor activity Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission. go.json neurotransmitter receptor activity involved in chemical synaptic transmission http://purl.obolibrary.org/obo/GO_0098960 GO:1902539 biolink:BiologicalProcess obsolete multi-organism macropinocytosis OBSOLETE. A macropinocytosis which involves another organism. go.json True http://purl.obolibrary.org/obo/GO_1902539 GO:1902537 biolink:BiologicalProcess obsolete multi-organism pinocytosis OBSOLETE. A pinocytosis which involves another organism. go.json True http://purl.obolibrary.org/obo/GO_1902537 GO:1902538 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902538 GO:1902535 biolink:BiologicalProcess obsolete multi-organism membrane invagination OBSOLETE. A membrane invagination which involves another organism. go.json True http://purl.obolibrary.org/obo/GO_1902535 GO:1902536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902536 GO:1902533 biolink:BiologicalProcess positive regulation of intracellular signal transduction Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. go.json activation of intracellular signal transduction|activation of intracellular signal transduction pathway|activation of intracellular signaling cascade|activation of intracellular signaling chain|activation of intracellular signaling pathway|activation of signal transduction via intracellular signaling cascade|activation of signal transmission via intracellular cascade|positive regulation of intracellular protein kinase cascade|positive regulation of intracellular signal transduction pathway|positive regulation of intracellular signaling cascade|positive regulation of intracellular signaling chain|positive regulation of intracellular signaling pathway|positive regulation of signal transduction via intracellular signaling cascade|positive regulation of signal transmission via intracellular cascade|up regulation of intracellular signal transduction|up regulation of intracellular signal transduction pathway|up regulation of intracellular signaling cascade|up regulation of intracellular signaling chain|up regulation of intracellular signaling pathway|up regulation of signal transduction via intracellular signaling cascade|up regulation of signal transmission via intracellular cascade|up-regulation of intracellular signal transduction|up-regulation of intracellular signal transduction pathway|up-regulation of intracellular signaling cascade|up-regulation of intracellular signaling chain|up-regulation of intracellular signaling pathway|up-regulation of signal transduction via intracellular signaling cascade|up-regulation of signal transmission via intracellular cascade|upregulation of intracellular signal transduction|upregulation of intracellular signal transduction pathway|upregulation of intracellular signaling cascade|upregulation of intracellular signaling chain|upregulation of intracellular signaling pathway|upregulation of signal transduction via intracellular signaling cascade|upregulation of signal transmission via intracellular cascade http://purl.obolibrary.org/obo/GO_1902533 GO:1902534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902534 GO:1902531 biolink:BiologicalProcess regulation of intracellular signal transduction Any process that modulates the frequency, rate or extent of intracellular signal transduction. go.json regulation of intracellular protein kinase cascade|regulation of intracellular signal transduction pathway|regulation of intracellular signaling cascade|regulation of intracellular signaling chain|regulation of intracellular signaling pathway|regulation of signal transduction via intracellular signaling cascade|regulation of signal transmission via intracellular cascade http://purl.obolibrary.org/obo/GO_1902531 GO:1902532 biolink:BiologicalProcess negative regulation of intracellular signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. go.json down regulation of intracellular signal transduction|down regulation of intracellular signal transduction pathway|down regulation of intracellular signaling cascade|down regulation of intracellular signaling chain|down regulation of intracellular signaling pathway|down regulation of signal transduction via intracellular signaling cascade|down regulation of signal transmission via intracellular cascade|down-regulation of intracellular signal transduction|down-regulation of intracellular signal transduction pathway|down-regulation of intracellular signaling cascade|down-regulation of intracellular signaling chain|down-regulation of intracellular signaling pathway|down-regulation of signal transduction via intracellular signaling cascade|down-regulation of signal transmission via intracellular cascade|downregulation of intracellular signal transduction|downregulation of intracellular signal transduction pathway|downregulation of intracellular signaling cascade|downregulation of intracellular signaling chain|downregulation of intracellular signaling pathway|downregulation of signal transduction via intracellular signaling cascade|downregulation of signal transmission via intracellular cascade|inhibition of intracellular signal transduction|inhibition of intracellular signal transduction pathway|inhibition of intracellular signaling cascade|inhibition of intracellular signaling chain|inhibition of intracellular signaling pathway|inhibition of signal transduction via intracellular signaling cascade|inhibition of signal transmission via intracellular cascade|negative regulation of intracellular protein kinase cascade|negative regulation of intracellular signal transduction pathway|negative regulation of intracellular signaling cascade|negative regulation of intracellular signaling chain|negative regulation of intracellular signaling pathway|negative regulation of signal transduction via intracellular signaling cascade|negative regulation of signal transmission via intracellular cascade http://purl.obolibrary.org/obo/GO_1902532 GO:0060350 biolink:BiologicalProcess endochondral bone morphogenesis The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. go.json http://purl.obolibrary.org/obo/GO_0060350 GO:0060351 biolink:BiologicalProcess cartilage development involved in endochondral bone morphogenesis The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. go.json http://purl.obolibrary.org/obo/GO_0060351 GO:1902530 biolink:BiologicalProcess positive regulation of protein linear polyubiquitination Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination. go.json activation of M1 linkage|activation of protein linear polyubiquitination|positive regulation of M1 linkage|up regulation of M1 linkage|up regulation of protein linear polyubiquitination|up-regulation of M1 linkage|up-regulation of protein linear polyubiquitination|upregulation of M1 linkage|upregulation of protein linear polyubiquitination http://purl.obolibrary.org/obo/GO_1902530 GO:0060352 biolink:BiologicalProcess cell adhesion molecule production The appearance of a cell adhesion molecule due to biosynthesis or secretion. go.json http://purl.obolibrary.org/obo/GO_0060352 GO:0035386 biolink:BiologicalProcess regulation of Roundabout signaling pathway Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway. go.json regulation of Roundabout signalling pathway http://purl.obolibrary.org/obo/GO_0035386 GO:0060353 biolink:BiologicalProcess regulation of cell adhesion molecule production Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. go.json http://purl.obolibrary.org/obo/GO_0060353 GO:0035387 biolink:BiologicalProcess negative regulation of Roundabout signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway. go.json negative regulation of Roundabout signalling pathway http://purl.obolibrary.org/obo/GO_0035387 GO:0060354 biolink:BiologicalProcess negative regulation of cell adhesion molecule production Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. go.json http://purl.obolibrary.org/obo/GO_0060354 GO:0035388 biolink:BiologicalProcess positive regulation of Roundabout signaling pathway Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway. go.json positive regulation of Roundabout signalling pathway http://purl.obolibrary.org/obo/GO_0035388 GO:0060355 biolink:BiologicalProcess positive regulation of cell adhesion molecule production Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. go.json http://purl.obolibrary.org/obo/GO_0060355 GO:0060356 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0060356 GO:0035389 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035389 GO:0060357 biolink:BiologicalProcess regulation of leucine import Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. go.json regulation of L-leucine import|regulation of L-leucine uptake|regulation of leucine uptake http://purl.obolibrary.org/obo/GO_0060357 GO:0060358 biolink:BiologicalProcess negative regulation of leucine import Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0060358 GO:0060359 biolink:BiologicalProcess response to ammonium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. go.json response to ammonia http://purl.obolibrary.org/obo/GO_0060359 GO:0098969 biolink:BiologicalProcess neurotransmitter receptor transport to postsynaptic membrane The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles. go.json http://purl.obolibrary.org/obo/GO_0098969 goslim_synapse GO:0035380 biolink:MolecularActivity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. go.json very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0035380 GO:0098967 biolink:BiologicalProcess exocytic insertion of neurotransmitter receptor to postsynaptic membrane The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion. go.json http://purl.obolibrary.org/obo/GO_0098967 goslim_synapse GO:0035381 biolink:MolecularActivity ATP-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0035381 GO:0098968 biolink:BiologicalProcess neurotransmitter receptor transport postsynaptic membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome. go.json http://purl.obolibrary.org/obo/GO_0098968 goslim_synapse GO:0035382 biolink:BiologicalProcess sterol transmembrane transport The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json sterol membrane transport http://purl.obolibrary.org/obo/GO_0035382 GO:0098965 biolink:CellularComponent extracellular matrix of synaptic cleft The portion of the extracellular matrix that lies within the synaptic cleft. go.json ECM of synaptic cleft|synaptic cleft ECM http://purl.obolibrary.org/obo/GO_0098965 goslim_synapse GO:0035383 biolink:BiologicalProcess thioester metabolic process The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. go.json thioester metabolism http://purl.obolibrary.org/obo/GO_0035383 GO:0098966 biolink:CellularComponent perisynaptic extracellular matrix The portion of the extracellular matrix that lies within the perisynaptic space. go.json extrasynaptic extracellular matrix|perisynaptic ECM http://purl.obolibrary.org/obo/GO_0098966 goslim_synapse GO:0098963 biolink:BiologicalProcess dendritic transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites. go.json dendritic transport of mRNA RNP complex http://purl.obolibrary.org/obo/GO_0098963 goslim_synapse GO:0035384 biolink:BiologicalProcess thioester biosynthetic process The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. go.json thioester anabolism|thioester biosynthesis|thioester formation|thioester synthesis http://purl.obolibrary.org/obo/GO_0035384 GO:0035385 biolink:BiologicalProcess Roundabout signaling pathway The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json ROBO signaling pathway|ROBO/SLIT signaling pathway|Roundabout signalling pathway http://purl.obolibrary.org/obo/GO_0035385 GO:0098964 biolink:BiologicalProcess anterograde dendritic transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse. go.json anterograde dendritic transport of mRNA RNP complex http://purl.obolibrary.org/obo/GO_0098964 goslim_synapse GO:0098972 biolink:BiologicalProcess anterograde dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body. go.json http://purl.obolibrary.org/obo/GO_0098972 goslim_synapse GO:0098973 biolink:MolecularActivity structural constituent of postsynaptic actin cytoskeleton The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0098973 goslim_synapse GO:0098970 biolink:BiologicalProcess postsynaptic neurotransmitter receptor diffusion trapping The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. go.json http://purl.obolibrary.org/obo/GO_0098970 goslim_synapse GO:0098971 biolink:BiologicalProcess anterograde dendritic transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0098971 goslim_synapse GO:1902548 biolink:BiologicalProcess negative regulation of cellular response to vascular endothelial growth factor stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. go.json down regulation of cellular response to VEGF|down regulation of cellular response to VEGFA|down regulation of cellular response to VEGFB|down regulation of cellular response to vascular endothelial growth factor|down regulation of cellular response to vascular endothelial growth factor stimulus|down-regulation of cellular response to VEGF|down-regulation of cellular response to VEGFA|down-regulation of cellular response to VEGFB|down-regulation of cellular response to vascular endothelial growth factor|down-regulation of cellular response to vascular endothelial growth factor stimulus|downregulation of cellular response to VEGF|downregulation of cellular response to VEGFA|downregulation of cellular response to VEGFB|downregulation of cellular response to vascular endothelial growth factor|downregulation of cellular response to vascular endothelial growth factor stimulus|inhibition of cellular response to VEGF|inhibition of cellular response to VEGFA|inhibition of cellular response to VEGFB|inhibition of cellular response to vascular endothelial growth factor|inhibition of cellular response to vascular endothelial growth factor stimulus|negative regulation of cellular response to VEGF|negative regulation of cellular response to VEGFA|negative regulation of cellular response to VEGFB|negative regulation of cellular response to vascular endothelial growth factor http://purl.obolibrary.org/obo/GO_1902548 GO:1902549 biolink:BiologicalProcess protein localization to Mei2 nuclear dot A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot. go.json protein localisation in Mei2 nuclear dot|protein localisation to Mei2 nuclear dot|protein localization in Mei2 nuclear dot|protein localization to Mei2 dot http://purl.obolibrary.org/obo/GO_1902549 GO:1902546 biolink:BiologicalProcess obsolete positive regulation of DNA N-glycosylase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA N-glycosylase activity. go.json activation of DNA N-glycosylase activity|activation of DNA glycosylase activity|activation of endonuclease VIII activity|positive regulation of DNA glycosylase activity|positive regulation of endonuclease VIII activity|up regulation of DNA N-glycosylase activity|up regulation of DNA glycosylase activity|up regulation of endonuclease VIII activity|up-regulation of DNA N-glycosylase activity|up-regulation of DNA glycosylase activity|up-regulation of endonuclease VIII activity|upregulation of DNA N-glycosylase activity|upregulation of DNA glycosylase activity|upregulation of endonuclease VIII activity True http://purl.obolibrary.org/obo/GO_1902546 GO:1902547 biolink:BiologicalProcess regulation of cellular response to vascular endothelial growth factor stimulus Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. go.json regulation of cellular response to VEGF|regulation of cellular response to VEGFA|regulation of cellular response to VEGFB|regulation of cellular response to vascular endothelial growth factor http://purl.obolibrary.org/obo/GO_1902547 GO:1902544 biolink:BiologicalProcess obsolete regulation of DNA N-glycosylase activity OBSOLETE. Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity. go.json regulation of DNA glycosylase activity|regulation of endonuclease VIII activity True http://purl.obolibrary.org/obo/GO_1902544 GO:1902545 biolink:BiologicalProcess obsolete negative regulation of DNA N-glycosylase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA N-glycosylase activity. go.json down regulation of DNA N-glycosylase activity|down regulation of DNA glycosylase activity|down regulation of endonuclease VIII activity|down-regulation of DNA N-glycosylase activity|down-regulation of DNA glycosylase activity|down-regulation of endonuclease VIII activity|downregulation of DNA N-glycosylase activity|downregulation of DNA glycosylase activity|downregulation of endonuclease VIII activity|inhibition of DNA N-glycosylase activity|inhibition of DNA glycosylase activity|inhibition of endonuclease VIII activity|negative regulation of DNA glycosylase activity|negative regulation of endonuclease VIII activity True http://purl.obolibrary.org/obo/GO_1902545 GO:1902542 biolink:BiologicalProcess regulation of protein localization to mitotic spindle pole body Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body. go.json regulation of protein localisation to mitotic spindle pole body http://purl.obolibrary.org/obo/GO_1902542 GO:1902543 biolink:BiologicalProcess negative regulation of protein localization to mitotic spindle pole body Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body. go.json down regulation of protein localisation to mitotic spindle pole body|down regulation of protein localization to mitotic spindle pole body|down-regulation of protein localisation in mitotic spindle pole body|down-regulation of protein localisation to mitotic spindle pole body|down-regulation of protein localization to mitotic spindle pole body|downregulation of protein localisation to mitotic spindle pole body|downregulation of protein localization to mitotic spindle pole body|inhibition of protein localisation to mitotic spindle pole body|inhibition of protein localization to mitotic spindle pole body|negative regulation of protein localisation to mitotic spindle pole body http://purl.obolibrary.org/obo/GO_1902543 GO:0060340 biolink:BiologicalProcess positive regulation of type I interferon-mediated signaling pathway Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. go.json positive regulation of type I interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0060340 GO:1902540 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902540 GO:1902541 biolink:BiologicalProcess obsolete multi-organism micropinocytosis OBSOLETE. A micropinocytosis which involves another organism. go.json True http://purl.obolibrary.org/obo/GO_1902541 GO:0060341 biolink:BiologicalProcess regulation of cellular localization Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. go.json regulation of cellular localisation http://purl.obolibrary.org/obo/GO_0060341 GO:0060342 biolink:CellularComponent photoreceptor inner segment membrane The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. go.json http://purl.obolibrary.org/obo/GO_0060342 GO:0035375 biolink:MolecularActivity zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis. go.json proenzyme binding http://purl.obolibrary.org/obo/GO_0035375 GO:0060343 biolink:BiologicalProcess trabecula formation The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. go.json trabecula biogenesis|trabeculation http://purl.obolibrary.org/obo/GO_0060343 GO:1902550 biolink:BiologicalProcess lymphoid lineage cell migration into thymus involved in thymus epithelium morphogenesis Any lymphoid lineage cell migration into thymus that is involved in thymus epithelium morphogenesis. go.json lymphoid lineage cell migration into thymus involved in thymic epithelium morphogenesis|lymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis|lymphoid lineage restricted progenitor cell migration into thymus involved in thymus epithelium morphogenesis http://purl.obolibrary.org/obo/GO_1902550 GO:0035376 biolink:BiologicalProcess sterol import The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json sterol influx|sterol uptake http://purl.obolibrary.org/obo/GO_0035376 GO:0060344 biolink:BiologicalProcess liver trabecula formation The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. go.json liver trabecula biogenesis|liver trabeculation http://purl.obolibrary.org/obo/GO_0060344 GO:0035377 biolink:BiologicalProcess transepithelial water transport The directed movement of water (H2O) from one side of an epithelium to the other. go.json http://purl.obolibrary.org/obo/GO_0035377 GO:0060345 biolink:BiologicalProcess spleen trabecula formation The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. go.json spleen trabecula biogenesis|spleen trabeculation http://purl.obolibrary.org/obo/GO_0060345 GO:0035378 biolink:BiologicalProcess carbon dioxide transmembrane transport The process in which carbon dioxide (CO2) is transported across a membrane. go.json carbon dioxide membrane transport http://purl.obolibrary.org/obo/GO_0035378 GO:0035379 biolink:MolecularActivity carbon dioxide transmembrane transporter activity Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other. Reactome:R-HSA-1237042|Reactome:R-HSA-1237069|Reactome:R-HSA-1247645|Reactome:R-HSA-1247649 go.json http://purl.obolibrary.org/obo/GO_0035379 GO:0060346 biolink:BiologicalProcess bone trabecula formation The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod. go.json bone trabecula biogenesis|bone trabeculation|skeletal trabecula biogenesis|skeletal trabecula formation|skeletal trabeculation http://purl.obolibrary.org/obo/GO_0060346 GO:0060347 biolink:BiologicalProcess heart trabecula formation The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. go.json cardiac trabecula formation|cardiac trabeculation|heart trabecula biogenesis|heart trabeculation http://purl.obolibrary.org/obo/GO_0060347 GO:0060348 biolink:BiologicalProcess bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. go.json http://purl.obolibrary.org/obo/GO_0060348 GO:0060349 biolink:BiologicalProcess bone morphogenesis The process in which bones are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060349 GO:0098978 biolink:CellularComponent glutamatergic synapse A synapse that uses glutamate as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0098978 goslim_synapse GO:0035370 biolink:CellularComponent UBC13-UEV1A complex A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A). go.json http://purl.obolibrary.org/obo/GO_0035370 GO:0098979 biolink:CellularComponent polyadic synapse A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems. go.json http://purl.obolibrary.org/obo/GO_0098979 GO:0035371 biolink:CellularComponent microtubule plus-end The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. go.json growing microtubule plus end|microtubule plus end http://purl.obolibrary.org/obo/GO_0035371 GO:0098976 biolink:BiologicalProcess excitatory chemical synaptic transmission Synaptic transmission that results in an excitatory postsynaptic potential. go.json http://purl.obolibrary.org/obo/GO_0098976 GO:0098977 biolink:BiologicalProcess inhibitory chemical synaptic transmission Synaptic transmission that results in an inhibitory postsynaptic potential. go.json http://purl.obolibrary.org/obo/GO_0098977 GO:0035372 biolink:BiologicalProcess protein localization to microtubule A process in which a protein is transported to, or maintained at, a microtubule. go.json protein localisation to microtubule http://purl.obolibrary.org/obo/GO_0035372 GO:0098974 biolink:BiologicalProcess postsynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0098974 goslim_synapse GO:0035373 biolink:MolecularActivity chondroitin sulfate proteoglycan binding Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. go.json http://purl.obolibrary.org/obo/GO_0035373 GO:0035374 biolink:MolecularActivity chondroitin sulfate binding Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). go.json http://purl.obolibrary.org/obo/GO_0035374 GO:0098975 biolink:CellularComponent postsynapse of neuromuscular junction The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. go.json http://purl.obolibrary.org/obo/GO_0098975 GO:0098940 biolink:BiologicalProcess anterograde trans-synaptic signaling by nitric oxide Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide. go.json http://purl.obolibrary.org/obo/GO_0098940 goslim_synapse GO:1902559 biolink:BiologicalProcess 3'-phospho-5'-adenylyl sulfate transmembrane transport The process in which 3'-phospho-5'-adenylyl sulfate is transported across a membrane. go.json 3'-phosphoadenosine 5'-phosphosulfate transmembrane transport http://purl.obolibrary.org/obo/GO_1902559 GO:1902557 biolink:MolecularActivity 5'-adenylyl sulfate transmembrane transporter activity Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1902557 GO:1902558 biolink:BiologicalProcess 5'-adenylyl sulfate transmembrane transport The process in which 5'-adenylyl sulfate is transported across a membrane. go.json adenosine 5'-phosphosulfate transmembrane transport http://purl.obolibrary.org/obo/GO_1902558 GO:1902555 biolink:CellularComponent endoribonuclease complex A protein complex which is capable of endoribonuclease activity. go.json Ire1 complex dimer|Ire1 complex homodimer|Ire1 complex homooligomer http://purl.obolibrary.org/obo/GO_1902555 GO:1902556 biolink:CellularComponent phosphatidylinositol transporter complex A protein complex which is capable of phosphatidylinositol transporter activity. go.json Ire1 complex dimer|Ire1 complex homodimer|Ire1 complex homooligomer http://purl.obolibrary.org/obo/GO_1902556 GO:0060370 biolink:BiologicalProcess susceptibility to T cell mediated cytotoxicity The process of causing a cell to become susceptible to T cell mediated cytotoxicity. go.json http://purl.obolibrary.org/obo/GO_0060370 GO:0060371 biolink:BiologicalProcess regulation of atrial cardiac muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. go.json atrial depolarization|electrocardiogram PR interval|regulation of atrial cardiac muscle cell depolarization|regulation of atrial cardiomyocyte membrane depolarization http://purl.obolibrary.org/obo/GO_0060371 GO:1902553 biolink:BiologicalProcess positive regulation of catalase activity Any process that activates or increases the frequency, rate or extent of catalase activity. go.json activation of CAT|activation of bacterial catalase-peroxidase activity|activation of caperase activity|activation of catalase activity|activation of catalase reaction|activation of catalase-peroxidase activity|activation of equilase activity|activation of haem catalase activity|activation of heme catalase activity|activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|activation of manganese catalase activity|activation of optidase activity|positive regulation of CAT|positive regulation of bacterial catalase-peroxidase activity|positive regulation of caperase activity|positive regulation of catalase reaction|positive regulation of catalase-peroxidase activity|positive regulation of equilase activity|positive regulation of haem catalase activity|positive regulation of heme catalase activity|positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|positive regulation of manganese catalase activity|positive regulation of optidase activity|up regulation of CAT|up regulation of bacterial catalase-peroxidase activity|up regulation of caperase activity|up regulation of catalase activity|up regulation of catalase reaction|up regulation of catalase-peroxidase activity|up regulation of equilase activity|up regulation of haem catalase activity|up regulation of heme catalase activity|up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|up regulation of manganese catalase activity|up regulation of optidase activity|up-regulation of CAT|up-regulation of bacterial catalase-peroxidase activity|up-regulation of caperase activity|up-regulation of catalase activity|up-regulation of catalase reaction|up-regulation of catalase-peroxidase activity|up-regulation of equilase activity|up-regulation of haem catalase activity|up-regulation of heme catalase activity|up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|up-regulation of manganese catalase activity|up-regulation of optidase activity|upregulation of CAT|upregulation of bacterial catalase-peroxidase activity|upregulation of caperase activity|upregulation of catalase activity|upregulation of catalase reaction|upregulation of catalase-peroxidase activity|upregulation of equilase activity|upregulation of haem catalase activity|upregulation of heme catalase activity|upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|upregulation of manganese catalase activity|upregulation of optidase activity http://purl.obolibrary.org/obo/GO_1902553 gocheck_do_not_annotate GO:1902554 biolink:CellularComponent serine/threonine protein kinase complex A protein complex which is capable of protein serine/threonine kinase activity. go.json PDR16 complex dimer|PDR16 complex homodimer http://purl.obolibrary.org/obo/GO_1902554 GO:0060372 biolink:BiologicalProcess regulation of atrial cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. go.json atrial repolarization|electrocardiogram QRS complex|regulation of atrial cardiac muscle cell repolarization|regulation of atrial cardiomyocyte membrane repolarization http://purl.obolibrary.org/obo/GO_0060372 GO:0060373 biolink:BiologicalProcess regulation of ventricular cardiac muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte. go.json electrocardiogram QRS complex|regulation of ventricular cardiomyocyte membrane depolarization|ventricular depolarization http://purl.obolibrary.org/obo/GO_0060373 GO:1902551 biolink:BiologicalProcess regulation of catalase activity Any process that modulates the frequency, rate or extent of catalase activity. go.json regulation of CAT|regulation of bacterial catalase-peroxidase activity|regulation of caperase activity|regulation of catalase reaction|regulation of catalase-peroxidase activity|regulation of equilase activity|regulation of haem catalase activity|regulation of heme catalase activity|regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|regulation of manganese catalase activity|regulation of optidase activity http://purl.obolibrary.org/obo/GO_1902551 gocheck_do_not_annotate GO:0060374 biolink:BiologicalProcess mast cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. go.json http://purl.obolibrary.org/obo/GO_0060374 GO:1902552 biolink:BiologicalProcess negative regulation of catalase activity Any process that stops, prevents or reduces the frequency, rate or extent of catalase activity. go.json down regulation of CAT|down regulation of bacterial catalase-peroxidase activity|down regulation of caperase activity|down regulation of catalase activity|down regulation of catalase reaction|down regulation of catalase-peroxidase activity|down regulation of equilase activity|down regulation of haem catalase activity|down regulation of heme catalase activity|down regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|down regulation of manganese catalase activity|down regulation of optidase activity|down-regulation of CAT|down-regulation of bacterial catalase-peroxidase activity|down-regulation of caperase activity|down-regulation of catalase activity|down-regulation of catalase reaction|down-regulation of catalase-peroxidase activity|down-regulation of equilase activity|down-regulation of haem catalase activity|down-regulation of heme catalase activity|down-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|down-regulation of manganese catalase activity|down-regulation of optidase activity|downregulation of CAT|downregulation of bacterial catalase-peroxidase activity|downregulation of caperase activity|downregulation of catalase activity|downregulation of catalase reaction|downregulation of catalase-peroxidase activity|downregulation of equilase activity|downregulation of haem catalase activity|downregulation of heme catalase activity|downregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|downregulation of manganese catalase activity|downregulation of optidase activity|inhibition of CAT|inhibition of bacterial catalase-peroxidase activity|inhibition of caperase activity|inhibition of catalase activity|inhibition of catalase reaction|inhibition of catalase-peroxidase activity|inhibition of equilase activity|inhibition of haem catalase activity|inhibition of heme catalase activity|inhibition of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|inhibition of manganese catalase activity|inhibition of optidase activity|negative regulation of CAT|negative regulation of bacterial catalase-peroxidase activity|negative regulation of caperase activity|negative regulation of catalase reaction|negative regulation of catalase-peroxidase activity|negative regulation of equilase activity|negative regulation of haem catalase activity|negative regulation of heme catalase activity|negative regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|negative regulation of manganese catalase activity|negative regulation of optidase activity http://purl.obolibrary.org/obo/GO_1902552 gocheck_do_not_annotate GO:0035364 biolink:BiologicalProcess thymine transport The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 5-methyluracil transport|thymine transmembrane transport http://purl.obolibrary.org/obo/GO_0035364 GO:0060375 biolink:BiologicalProcess regulation of mast cell differentiation Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. go.json http://purl.obolibrary.org/obo/GO_0060375 GO:1902560 biolink:CellularComponent GMP reductase complex An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H+ + NADPH => IMP + NADP+ + NH4. go.json GMP reductase|GMPR1 complex|GMPR2 complex|guanosine monophosphate reductase http://purl.obolibrary.org/obo/GO_1902560 GO:0060376 biolink:BiologicalProcess positive regulation of mast cell differentiation Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. go.json http://purl.obolibrary.org/obo/GO_0060376 GO:1902561 biolink:BiologicalProcess origin recognition complex assembly The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex. go.json ORC assembly|ORC formation|origin of replication recognition complex assembly|origin of replication recognition complex formation|origin recognition complex formation http://purl.obolibrary.org/obo/GO_1902561 GO:0035365 biolink:BiologicalProcess regulation of thymine transport Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of 5-methyluracil transport http://purl.obolibrary.org/obo/GO_0035365 GO:0060377 biolink:BiologicalProcess negative regulation of mast cell differentiation Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. go.json http://purl.obolibrary.org/obo/GO_0060377 GO:0035366 biolink:BiologicalProcess negative regulation of thymine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json negative regulation of 5-methyluracil transport http://purl.obolibrary.org/obo/GO_0035366 GO:0060378 biolink:BiologicalProcess regulation of brood size Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. go.json http://purl.obolibrary.org/obo/GO_0060378 GO:0035367 biolink:BiologicalProcess positive regulation of thymine transport Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json positive regulation of 5-methyluracil transport http://purl.obolibrary.org/obo/GO_0035367 GO:0060379 biolink:BiologicalProcess cardiac muscle cell myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. go.json cardiac myoblast differentiation|myocardial precursor cell differentiation http://purl.obolibrary.org/obo/GO_0060379 GO:0035368 biolink:MolecularActivity selenocysteine insertion sequence binding Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. go.json SECIS binding http://purl.obolibrary.org/obo/GO_0035368 GO:0035369 biolink:CellularComponent pre-B cell receptor complex An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json pre-BCR http://purl.obolibrary.org/obo/GO_0035369 GO:0098949 biolink:CellularComponent obsolete intrinsic component of postsynaptic endosome membrane OBSOLETE. The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic endosome membrane True http://purl.obolibrary.org/obo/GO_0098949 GO:0098947 biolink:CellularComponent obsolete intrinsic component of postsynaptic endocytic zone membrane OBSOLETE. The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic acive zone membrane True http://purl.obolibrary.org/obo/GO_0098947 GO:0098948 biolink:CellularComponent obsolete intrinsic component of postsynaptic specialization membrane OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic specialization membrane True http://purl.obolibrary.org/obo/GO_0098948 GO:0098945 biolink:CellularComponent obsolete intrinsic component of presynaptic active zone membrane OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to presynaptic acive zone membrane True http://purl.obolibrary.org/obo/GO_0098945 GO:0098946 biolink:CellularComponent obsolete intrinsic component of presynaptic endocytic zone membrane OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to presynaptic acive zone membrane True http://purl.obolibrary.org/obo/GO_0098946 GO:0098943 biolink:BiologicalProcess neurotransmitter receptor transport, postsynaptic endosome to lysosome The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation. go.json postsynaptic neurotransmitter receptor endosomal trafficking http://purl.obolibrary.org/obo/GO_0098943 goslim_synapse GO:0035360 biolink:BiologicalProcess positive regulation of peroxisome proliferator activated receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. go.json positive regulation of PPAR signaling pathway|positive regulation of peroxisome proliferator activated receptor signalling pathway|positive regulation of peroxisome proliferator-activated receptor signaling pathway http://purl.obolibrary.org/obo/GO_0035360 GO:0098944 biolink:CellularComponent postsynaptic recycling endosome membrane The lipid bilayer surrounding a postsynaptic recycling endosome. go.json http://purl.obolibrary.org/obo/GO_0098944 goslim_synapse GO:0035361 biolink:CellularComponent Cul8-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins. go.json http://purl.obolibrary.org/obo/GO_0035361 GO:0098941 biolink:BiologicalProcess anterograde trans-synaptic signaling by trans-synaptic protein complex Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex. go.json http://purl.obolibrary.org/obo/GO_0098941 goslim_synapse GO:0035362 biolink:BiologicalProcess protein-DNA ISRE complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA. go.json protein-DNA interferon-stimulated response element complex assembly http://purl.obolibrary.org/obo/GO_0035362 GO:0035363 biolink:CellularComponent histone locus body A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body. go.json HLB http://purl.obolibrary.org/obo/GO_0035363 GO:0098942 biolink:BiologicalProcess retrograde trans-synaptic signaling by trans-synaptic protein complex Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex. go.json http://purl.obolibrary.org/obo/GO_0098942 goslim_synapse GO:0098950 biolink:CellularComponent obsolete intrinsic component of postsynaptic early endosome membrane OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic early endosome membrane True http://purl.obolibrary.org/obo/GO_0098950 GO:0098951 biolink:CellularComponent obsolete intrinsic component of postsynaptic recycling endosome membrane OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic recycling endosome membrane True http://purl.obolibrary.org/obo/GO_0098951 GO:2001105 biolink:BiologicalProcess maltoheptaose transport The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001105 GO:1902568 biolink:BiologicalProcess positive regulation of eosinophil activation Any process that activates or increases the frequency, rate or extent of eosinophil activation. go.json activation of eosinophil activation|up regulation of eosinophil activation|up-regulation of eosinophil activation|upregulation of eosinophil activation http://purl.obolibrary.org/obo/GO_1902568 GO:1902569 biolink:BiologicalProcess negative regulation of activation of Janus kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity. go.json down regulation of activation of JAK1 kinase activity|down regulation of activation of JAK1 protein|down regulation of activation of JAK2 kinase activity|down regulation of activation of JAK2 protein|down regulation of tyrosine phosphorylation of JAK1 protein|down regulation of tyrosine phosphorylation of JAK2 protein|down-regulation of activation of JAK1 kinase activity|down-regulation of activation of JAK1 protein|down-regulation of activation of JAK2 kinase activity|down-regulation of activation of JAK2 protein|down-regulation of tyrosine phosphorylation of JAK1 protein|down-regulation of tyrosine phosphorylation of JAK2 protein|downregulation of activation of JAK1 kinase activity|downregulation of activation of JAK1 protein|downregulation of activation of JAK2 kinase activity|downregulation of tyrosine phosphorylation of JAK1 protein|downregulation of tyrosine phosphorylation of JAK2 protein|inhibition of activation of JAK1 kinase activity|inhibition of activation of JAK1 protein|inhibition of activation of JAK2 kinase activity|inhibition of activation of JAK2 protein|inhibition of tyrosine phosphorylation of JAK1 protein|inhibition of tyrosine phosphorylation of JAK2 protein|negative regulation of activation of JAK1 protein|negative regulation of activation of JAK2 kinase activity|negative regulation of activation of JAK2 protein|negative regulation of tyrosine phosphorylation of JAK1 protein|negative regulation of tyrosine phosphorylation of JAK2 protein http://purl.obolibrary.org/obo/GO_1902569 gocheck_do_not_annotate GO:2001106 biolink:BiologicalProcess regulation of Rho guanyl-nucleotide exchange factor activity Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. go.json regulation of Rho guanine nucleotide exchange factor|regulation of RhoGEF http://purl.obolibrary.org/obo/GO_2001106 gocheck_do_not_annotate GO:1902566 biolink:BiologicalProcess regulation of eosinophil activation Any process that modulates the frequency, rate or extent of eosinophil activation. go.json http://purl.obolibrary.org/obo/GO_1902566 GO:2001107 biolink:BiologicalProcess negative regulation of Rho guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. go.json negative regulation of Rho guanine nucleotide exchange factor|negative regulation of RhoGEF http://purl.obolibrary.org/obo/GO_2001107 gocheck_do_not_annotate GO:1902567 biolink:BiologicalProcess negative regulation of eosinophil activation Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation. go.json down regulation of eosinophil activation|down-regulation of eosinophil activation|downregulation of eosinophil activation|inhibition of eosinophil activation http://purl.obolibrary.org/obo/GO_1902567 GO:2001108 biolink:BiologicalProcess positive regulation of Rho guanyl-nucleotide exchange factor activity Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. go.json positive regulation of Rho guanine nucleotide exchange factor|positive regulation of RhoGEF http://purl.obolibrary.org/obo/GO_2001108 gocheck_do_not_annotate GO:0060360 biolink:BiologicalProcess negative regulation of leucine import in response to ammonium ion Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle. go.json negative regulation of leucine uptake in response to ammonium ion http://purl.obolibrary.org/obo/GO_0060360 GO:1902564 biolink:BiologicalProcess negative regulation of neutrophil activation Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation. go.json down regulation of neutrophil activation|down-regulation of neutrophil activation|downregulation of neutrophil activation|inhibition of neutrophil activation http://purl.obolibrary.org/obo/GO_1902564 GO:2001109 biolink:BiologicalProcess regulation of lens epithelial cell proliferation Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2001109 GO:0060361 biolink:BiologicalProcess flight Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement. go.json http://purl.obolibrary.org/obo/GO_0060361 GO:1902565 biolink:BiologicalProcess positive regulation of neutrophil activation Any process that activates or increases the frequency, rate or extent of neutrophil activation. go.json activation of neutrophil activation|up regulation of neutrophil activation|up-regulation of neutrophil activation|upregulation of neutrophil activation http://purl.obolibrary.org/obo/GO_1902565 GO:1902562 biolink:CellularComponent H4 histone acetyltransferase complex A protein complex which is capable of H4 histone acetyltransferase activity. go.json Hpa3 (homo-)dimer|Hpa3 complex http://purl.obolibrary.org/obo/GO_1902562 GO:0060362 biolink:BiologicalProcess flight involved in flight behavior Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight. go.json http://purl.obolibrary.org/obo/GO_0060362 GO:0060363 biolink:BiologicalProcess cranial suture morphogenesis The process in which any suture between cranial bones is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060363 GO:1902563 biolink:BiologicalProcess regulation of neutrophil activation Any process that modulates the frequency, rate or extent of neutrophil activation. go.json http://purl.obolibrary.org/obo/GO_1902563 GO:1902571 biolink:BiologicalProcess regulation of serine-type peptidase activity Any process that modulates the frequency, rate or extent of serine-type peptidase activity. go.json regulation of serine protease activity http://purl.obolibrary.org/obo/GO_1902571 gocheck_do_not_annotate GO:0060364 biolink:BiologicalProcess frontal suture morphogenesis The process in which the frontal suture is generated and organized. go.json interfrontal suture morphogenesis http://purl.obolibrary.org/obo/GO_0060364 GO:0035353 biolink:BiologicalProcess nicotinamide mononucleotide transmembrane transport The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. go.json nicotinamide mononucleotide membrane transport http://purl.obolibrary.org/obo/GO_0035353 GO:0035354 biolink:CellularComponent Toll-like receptor 1-Toll-like receptor 2 protein complex A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2). go.json TLR1-TLR2 protein complex|TLR1:TLR2 complex|TLR2:TLR1 heterodimer|toll-like receptor TLR1:TLR2 heterodimeric complex http://purl.obolibrary.org/obo/GO_0035354 GO:1902572 biolink:BiologicalProcess negative regulation of serine-type peptidase activity Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. go.json down regulation of serine protease activity|down regulation of serine-type peptidase activity|down-regulation of serine protease activity|down-regulation of serine-type peptidase activity|downregulation of serine protease activity|downregulation of serine-type peptidase activity|inhibition of serine protease activity|inhibition of serine-type peptidase activity|negative regulation of serine protease activity http://purl.obolibrary.org/obo/GO_1902572 gocheck_do_not_annotate GO:0060365 biolink:BiologicalProcess coronal suture morphogenesis The process in which the coronal suture is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060365 GO:0035355 biolink:CellularComponent Toll-like receptor 2-Toll-like receptor 6 protein complex A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6). go.json TLR2-TLR6 protein complex|TLR2:TLR6 heterodimer|TLR6:TLR2 complex|toll-like receptor TLR6:TLR2 heterodimeric complex http://purl.obolibrary.org/obo/GO_0035355 GO:0060366 biolink:BiologicalProcess lambdoid suture morphogenesis The process in which the lambdoid suture is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060366 GO:0060367 biolink:BiologicalProcess sagittal suture morphogenesis The process in which the sagittal suture is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0060367 GO:1902570 biolink:BiologicalProcess protein localization to nucleolus A process in which a protein is transported to, or maintained in, a location within a nucleolus. go.json protein localisation in nucleolus|protein localisation to nucleolus|protein localization in nucleolus http://purl.obolibrary.org/obo/GO_1902570 GO:0035356 biolink:BiologicalProcess intracellular triglyceride homeostasis A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell. go.json cellular triglyceride homeostasis http://purl.obolibrary.org/obo/GO_0035356 GO:2001100 biolink:BiologicalProcess pentasaccharide transport The directed movement of a pentasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001100 GO:2001101 biolink:BiologicalProcess maltopentaose transport The directed movement of a maltopentaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001101 GO:0035357 biolink:BiologicalProcess peroxisome proliferator activated receptor signaling pathway The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. go.json PPAR signaling pathway|peroxisome proliferator activated receptor signalling pathway|peroxisome proliferator-activated receptor signaling pathway http://purl.obolibrary.org/obo/GO_0035357 GO:0060368 biolink:BiologicalProcess regulation of Fc receptor mediated stimulatory signaling pathway Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway.. go.json regulation of Fc receptor mediated stimulatory signalling pathway http://purl.obolibrary.org/obo/GO_0060368 GO:0060369 biolink:BiologicalProcess positive regulation of Fc receptor mediated stimulatory signaling pathway Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. go.json positive regulation of Fc receptor mediated stimulatory signalling pathway http://purl.obolibrary.org/obo/GO_0060369 GO:0035358 biolink:BiologicalProcess regulation of peroxisome proliferator activated receptor signaling pathway Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. go.json regulation of PPAR signaling pathway|regulation of peroxisome proliferator activated receptor signalling pathway|regulation of peroxisome proliferator-activated receptor signaling pathway http://purl.obolibrary.org/obo/GO_0035358 GO:2001102 biolink:BiologicalProcess hexasaccharide transport The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001102 GO:0035359 biolink:BiologicalProcess negative regulation of peroxisome proliferator activated receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. go.json negative regulation of PPAR signaling pathway|negative regulation of peroxisome proliferator activated receptor signalling pathway|negative regulation of peroxisome proliferator-activated receptor signaling pathway http://purl.obolibrary.org/obo/GO_0035359 GO:2001103 biolink:BiologicalProcess maltohexaose transport The directed movement of a maltohexaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001103 GO:2001104 biolink:BiologicalProcess heptasaccharide transport The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001104 GO:0098958 biolink:BiologicalProcess retrograde axonal transport of mitochondrion The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse. go.json retrograde axon transport of mitochondria http://purl.obolibrary.org/obo/GO_0098958 goslim_synapse GO:0098959 biolink:BiologicalProcess retrograde dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse. go.json retrograde dendrite transport of mitochondria http://purl.obolibrary.org/obo/GO_0098959 goslim_synapse GO:0098956 biolink:CellularComponent obsolete intrinsic component of dense core granule membrane OBSOLETE. The component of the dense core granule membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to dense core granule membrane True http://purl.obolibrary.org/obo/GO_0098956 GO:0098957 biolink:BiologicalProcess anterograde axonal transport of mitochondrion The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. go.json anterograde axon transport of mitochondria http://purl.obolibrary.org/obo/GO_0098957 goslim_synapse GO:0098954 biolink:CellularComponent presynaptic endosome membrane The lipid bilayer surrounding a presynaptic endosome. go.json http://purl.obolibrary.org/obo/GO_0098954 goslim_synapse GO:0098955 biolink:CellularComponent obsolete intrinsic component of presynaptic endosome membrane OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to presynaptic endosome membrane True http://purl.obolibrary.org/obo/GO_0098955 GO:0035350 biolink:BiologicalProcess FAD transmembrane transport The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. go.json FAD membrane transport http://purl.obolibrary.org/obo/GO_0035350 GO:0035351 biolink:BiologicalProcess heme transmembrane transport The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json heme membrane transport http://purl.obolibrary.org/obo/GO_0035351 GO:0098952 biolink:CellularComponent obsolete intrinsic component of spine apparatus membrane OBSOLETE. The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to spine apparatus membrane True http://purl.obolibrary.org/obo/GO_0098952 GO:0035352 biolink:BiologicalProcess NAD transmembrane transport The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH. go.json NAD membrane transport http://purl.obolibrary.org/obo/GO_0035352 GO:0098953 biolink:BiologicalProcess receptor diffusion trapping The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix. go.json http://purl.obolibrary.org/obo/GO_0098953 GO:1902579 biolink:BiologicalProcess obsolete multi-organism localization OBSOLETE. A localization which involves another organism. go.json multi organism localization True http://purl.obolibrary.org/obo/GO_1902579 GO:0060390 biolink:BiologicalProcess regulation of SMAD protein signal transduction Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. go.json SMAD protein import into nucleus|regulation of SMAD protein nuclear translocation http://purl.obolibrary.org/obo/GO_0060390 GO:1902577 biolink:BiologicalProcess protein localization to medial cortical node A process in which a protein is transported to, or maintained in, a location within a medial cortical node. go.json protein localisation in medial cortical node|protein localisation to medial cortical node|protein localization in medial cortical node http://purl.obolibrary.org/obo/GO_1902577 GO:0060391 biolink:BiologicalProcess positive regulation of SMAD protein signal transduction Any process that increases the rate, frequency or extent of SMAD protein signal transduction. go.json positive regulation of SMAD protein import into nucleus|positive regulation of SMAD protein nuclear translocation http://purl.obolibrary.org/obo/GO_0060391 GO:0060392 biolink:BiologicalProcess negative regulation of SMAD protein signal transduction Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. go.json negative regulation of SMAD protein import into nucleus|negative regulation of SMAD protein nuclear translocation http://purl.obolibrary.org/obo/GO_0060392 GO:1902578 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902578 GO:1902575 biolink:BiologicalProcess protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly Any protein localization to cell division site that is involved in cytokinesis, actomyosin contractile ring assembly. go.json protein localisation to cell division site involved in constriction ring assembly|protein localisation to cell division site involved in contractile ring assembly|protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring assembly|protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring formation|protein localisation to cell division site involved in cytokinesis, actomyosin ring biosynthesis|protein localisation to cell division site involved in cytokinesis, actomyosin ring formation|protein localisation to cell division site involved in cytokinesis, contractile ring assembly|protein localization to cell division site involved in constriction ring assembly|protein localization to cell division site involved in contractile ring assembly|protein localization to cell division site involved in cytokinesis, actomyosin contractile ring formation|protein localization to cell division site involved in cytokinesis, actomyosin ring biosynthesis|protein localization to cell division site involved in cytokinesis, actomyosin ring formation|protein localization to cell division site involved in cytokinesis, contractile ring assembly http://purl.obolibrary.org/obo/GO_1902575 GO:0060393 biolink:BiologicalProcess obsolete regulation of pathway-restricted SMAD protein phosphorylation OBSOLETE. Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. go.json True http://purl.obolibrary.org/obo/GO_0060393 GO:0060394 biolink:BiologicalProcess obsolete negative regulation of pathway-restricted SMAD protein phosphorylation OBSOLETE. Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. go.json True http://purl.obolibrary.org/obo/GO_0060394 GO:1902576 biolink:BiologicalProcess negative regulation of nuclear cell cycle DNA replication Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication. go.json down regulation of DNA replication during S phase|down regulation of DNA replication involved in S phase|down regulation of DNA replication involved in S-phase|down regulation of nuclear cell cycle DNA replication|down-regulation of DNA replication during S phase|down-regulation of DNA replication involved in S phase|down-regulation of DNA replication involved in S-phase|down-regulation of nuclear cell cycle DNA replication|downregulation of DNA replication during S phase|downregulation of DNA replication involved in S phase|downregulation of DNA replication involved in S-phase|downregulation of nuclear cell cycle DNA replication|inhibition of DNA replication during S phase|inhibition of DNA replication involved in S phase|inhibition of DNA replication involved in S-phase|inhibition of nuclear cell cycle DNA replication|negative regulation of DNA replication during S phase|negative regulation of DNA replication involved in S phase|negative regulation of DNA replication involved in S-phase http://purl.obolibrary.org/obo/GO_1902576 GO:1902573 biolink:BiologicalProcess positive regulation of serine-type peptidase activity Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity. go.json activation of serine protease activity|activation of serine-type peptidase activity|positive regulation of serine protease activity|up regulation of serine protease activity|up regulation of serine-type peptidase activity|up-regulation of serine protease activity|up-regulation of serine-type peptidase activity|upregulation of serine protease activity|upregulation of serine-type peptidase activity http://purl.obolibrary.org/obo/GO_1902573 gocheck_do_not_annotate GO:0060395 biolink:BiologicalProcess SMAD protein signal transduction An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. go.json http://purl.obolibrary.org/obo/GO_0060395 GO:1902574 biolink:BiologicalProcess obsolete negative regulation of leucine import by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of leucine import. go.json True http://purl.obolibrary.org/obo/GO_1902574 GO:0060396 biolink:BiologicalProcess growth hormone receptor signaling pathway The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. go.json GH receptor signaling pathway|cellular response to growth hormone|growth hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060396 GO:0035342 biolink:BiologicalProcess positive regulation of inosine transport Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json positive regulation of hypoxanthine riboside transport http://purl.obolibrary.org/obo/GO_0035342 GO:0060397 biolink:BiologicalProcess growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. go.json JAK-STAT cascade involved in growth hormone signalling pathway http://purl.obolibrary.org/obo/GO_0060397 GO:1902582 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902582 GO:0035343 biolink:BiologicalProcess negative regulation of inosine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json negative regulation of hypoxanthine riboside transport http://purl.obolibrary.org/obo/GO_0035343 GO:0060398 biolink:BiologicalProcess regulation of growth hormone receptor signaling pathway Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. go.json regulation of growth hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060398 GO:1902583 biolink:BiologicalProcess obsolete multi-organism intracellular transport OBSOLETE. An intracellular transport which involves another organism. go.json multi organism intracellular transport True http://purl.obolibrary.org/obo/GO_1902583 GO:0060399 biolink:BiologicalProcess positive regulation of growth hormone receptor signaling pathway Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. go.json positive regulation of growth hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0060399 GO:0035344 biolink:BiologicalProcess hypoxanthine transport The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 6-hydroxypurine transport|hypoxanthine transmembrane transport http://purl.obolibrary.org/obo/GO_0035344 GO:1902580 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902580 GO:0035345 biolink:BiologicalProcess regulation of hypoxanthine transport Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of 6-hydroxypurine transport http://purl.obolibrary.org/obo/GO_0035345 GO:1902581 biolink:BiologicalProcess obsolete multi-organism cellular localization OBSOLETE. A cellular localization which involves another organism. go.json multi organism cellular localization True http://purl.obolibrary.org/obo/GO_1902581 GO:0035346 biolink:BiologicalProcess positive regulation of hypoxanthine transport Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json positive regulation of 6-hydroxypurine transport http://purl.obolibrary.org/obo/GO_0035346 GO:0035347 biolink:BiologicalProcess negative regulation of hypoxanthine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json negative regulation of 6-hydroxypurine transport http://purl.obolibrary.org/obo/GO_0035347 GO:0035348 biolink:BiologicalProcess acetyl-CoA transmembrane transport The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. go.json acetyl-CoA membrane transport http://purl.obolibrary.org/obo/GO_0035348 GO:0035349 biolink:BiologicalProcess coenzyme A transmembrane transport The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. go.json coenzyme A membrane transport http://purl.obolibrary.org/obo/GO_0035349 GO:0035340 biolink:BiologicalProcess inosine transport The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json hypoxanthine riboside transport http://purl.obolibrary.org/obo/GO_0035340 GO:0035341 biolink:BiologicalProcess regulation of inosine transport Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of hypoxanthine riboside transport http://purl.obolibrary.org/obo/GO_0035341 GO:0035339 biolink:CellularComponent SPOTS complex A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. go.json serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex http://purl.obolibrary.org/obo/GO_0035339 GO:1902588 biolink:BiologicalProcess obsolete multi-organism plasmodesmata-mediated intercellular transport OBSOLETE. A plasmodesmata-mediated intercellular transport which involves another organism. go.json multi organism plasmodesmata-mediated intercellular transport True http://purl.obolibrary.org/obo/GO_1902588 GO:0060380 biolink:BiologicalProcess regulation of single-stranded telomeric DNA binding Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA. go.json regulation of telomeric ssDNA binding http://purl.obolibrary.org/obo/GO_0060380 gocheck_do_not_annotate GO:0060381 biolink:BiologicalProcess positive regulation of single-stranded telomeric DNA binding Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding. go.json positive regulation of telomeric ssDNA binding http://purl.obolibrary.org/obo/GO_0060381 gocheck_do_not_annotate GO:1902589 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902589 GO:1902586 biolink:BiologicalProcess obsolete multi-organism intercellular transport OBSOLETE. An intercellular transport which involves another organism. go.json multi organism intercellular transport True http://purl.obolibrary.org/obo/GO_1902586 GO:0060382 biolink:BiologicalProcess regulation of DNA strand elongation Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. go.json http://purl.obolibrary.org/obo/GO_0060382 GO:0060383 biolink:BiologicalProcess positive regulation of DNA strand elongation Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. go.json http://purl.obolibrary.org/obo/GO_0060383 GO:1902587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902587 GO:1902584 biolink:BiologicalProcess positive regulation of response to water deprivation Any process that activates or increases the frequency, rate or extent of response to water deprivation. go.json activation of drought tolerance|activation of response to dehydration|activation of response to drought|activation of response to thirst|activation of response to water deprivation|positive regulation of drought tolerance|positive regulation of response to dehydration|positive regulation of response to drought|positive regulation of response to thirst|up regulation of drought tolerance|up regulation of response to dehydration|up regulation of response to drought|up regulation of response to thirst|up regulation of response to water deprivation|up-regulation of drought tolerance|up-regulation of response to dehydration|up-regulation of response to drought|up-regulation of response to thirst|up-regulation of response to water deprivation|upregulation of drought tolerance|upregulation of response to dehydration|upregulation of response to drought|upregulation of response to thirst|upregulation of response to water deprivation http://purl.obolibrary.org/obo/GO_1902584 GO:0060384 biolink:BiologicalProcess innervation The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. go.json http://purl.obolibrary.org/obo/GO_0060384 GO:1902585 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902585 GO:0060385 biolink:BiologicalProcess axonogenesis involved in innervation The neurite development process that generates a long process of a neuron, as it invades a target tissue. go.json http://purl.obolibrary.org/obo/GO_0060385 GO:0060386 biolink:BiologicalProcess synapse assembly involved in innervation The assembly of a synapse within a target tissue in which a nerve is invading. go.json synapse biogenesis involved in innervation|synaptogenesis involved in innervation http://purl.obolibrary.org/obo/GO_0060386 GO:0035331 biolink:BiologicalProcess negative regulation of hippo signaling Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling. go.json negative regulation of hippo signaling cascade|negative regulation of hippo signaling pathway|negative regulation of hippo signalling cascade http://purl.obolibrary.org/obo/GO_0035331 GO:1902593 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902593 GO:1902594 biolink:BiologicalProcess obsolete multi-organism nuclear import OBSOLETE. A nuclear import which involves another organism. go.json multi organism nuclear import True http://purl.obolibrary.org/obo/GO_1902594 GO:0060387 biolink:CellularComponent fertilization envelope A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release. go.json fertilization membrane http://purl.obolibrary.org/obo/GO_0060387 GO:0035332 biolink:BiologicalProcess positive regulation of hippo signaling Any process that activates or increases the frequency, rate or extent of hippo signaling. go.json positive regulation of hippo signaling cascade|positive regulation of hippo signaling pathway|positive regulation of hippo signalling cascade http://purl.obolibrary.org/obo/GO_0035332 GO:0035333 biolink:BiologicalProcess Notch receptor processing, ligand-dependent The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). go.json Notch S2 cleavage|Notch S3 cleavage http://purl.obolibrary.org/obo/GO_0035333 GO:0060388 biolink:CellularComponent vitelline envelope A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization. go.json fertilization membrane http://purl.obolibrary.org/obo/GO_0060388 GO:1902591 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902591 GO:0035334 biolink:BiologicalProcess Notch receptor processing, ligand-independent The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface. go.json Notch S1 cleavage http://purl.obolibrary.org/obo/GO_0035334 GO:0060389 biolink:BiologicalProcess obsolete pathway-restricted SMAD protein phosphorylation OBSOLETE. The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. go.json R-SMAD protein phosphorylation|pathway restricted SMAD protein phosphorylation|receptor regulated SMAD protein phosphorylation|receptor-regulated SMAD protein phosphorylation True http://purl.obolibrary.org/obo/GO_0060389 GO:1902592 biolink:BiologicalProcess obsolete multi-organism membrane budding OBSOLETE. A membrane budding which involves another organism. go.json multi organism membrane budding True http://purl.obolibrary.org/obo/GO_1902592 GO:0035335 biolink:BiologicalProcess peptidyl-tyrosine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. go.json http://purl.obolibrary.org/obo/GO_0035335 gocheck_do_not_annotate GO:0035336 biolink:BiologicalProcess long-chain fatty-acyl-CoA metabolic process The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. go.json long-chain fatty acyl CoA metabolic process|long-chain fatty acyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0035336 GO:1902590 biolink:BiologicalProcess obsolete multi-organism organelle organization OBSOLETE. An organelle organization which involves another organism. go.json multi organism organelle organization True http://purl.obolibrary.org/obo/GO_1902590 GO:0035337 biolink:BiologicalProcess fatty-acyl-CoA metabolic process The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. go.json fatty acyl CoA metabolic process|fatty-acyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0035337 GO:0035338 biolink:BiologicalProcess long-chain fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. go.json long-chain fatty acyl CoA biosynthetic process|long-chain fatty-acyl-CoA anabolism|long-chain fatty-acyl-CoA biosynthesis|long-chain fatty-acyl-CoA formation|long-chain fatty-acyl-CoA synthesis http://purl.obolibrary.org/obo/GO_0035338 GO:0035330 biolink:BiologicalProcess regulation of hippo signaling Any process that modulates the frequency, rate or extent of hippo signaling. go.json regulation of hippo signaling cascade|regulation of hippo signaling pathway|regulation of hippo signalling cascade http://purl.obolibrary.org/obo/GO_0035330 GO:0098983 biolink:CellularComponent symmetric, GABA-ergic, inhibitory synapse A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials. go.json http://purl.obolibrary.org/obo/GO_0098983 GO:0098984 biolink:CellularComponent neuron to neuron synapse A synapse in which pre and post-synaptic cells are neurons. go.json http://purl.obolibrary.org/obo/GO_0098984 GO:0098981 biolink:CellularComponent cholinergic synapse A synapse that uses acetylcholine as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0098981 goslim_synapse GO:0098982 biolink:CellularComponent GABA-ergic synapse A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. go.json http://purl.obolibrary.org/obo/GO_0098982 goslim_synapse GO:0098980 biolink:CellularComponent presynaptic density An electron dense specialization of the presynaptic active zone cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0098980 GO:0035328 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035328 GO:0035329 biolink:BiologicalProcess hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. go.json SWH pathway|Salvador-Warts-Hippo signaling pathway|hippo signal transduction|hippo signaling cascade|hippo signaling pathway|hippo signalling cascade http://purl.obolibrary.org/obo/GO_0035329 GO:1902599 biolink:BiologicalProcess sulfathiazole transmembrane transport The directed movement of sulfathiazole across a membrane. go.json sulfathiazole transport|sulphathiazole transport http://purl.obolibrary.org/obo/GO_1902599 GO:1902597 biolink:BiologicalProcess positive regulation of DNA replication origin binding Any process that activates or increases the frequency, rate or extent of DNA replication origin binding. go.json activation of ARS binding|activation of DNA replication origin binding|positive regulation of ARS binding|up regulation of ARS binding|up regulation of DNA replication origin binding|up-regulation of ARS binding|up-regulation of DNA replication origin binding|upregulation of ARS binding|upregulation of DNA replication origin binding http://purl.obolibrary.org/obo/GO_1902597 gocheck_do_not_annotate GO:1902598 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902598 GO:1902595 biolink:BiologicalProcess regulation of DNA replication origin binding Any process that modulates the frequency, rate or extent of DNA replication origin binding. go.json regulation of ARS binding http://purl.obolibrary.org/obo/GO_1902595 gocheck_do_not_annotate GO:1902596 biolink:BiologicalProcess negative regulation of DNA replication origin binding Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding. go.json down regulation of ARS binding|down regulation of DNA replication origin binding|down-regulation of ARS binding|down-regulation of DNA replication origin binding|downregulation of ARS binding|downregulation of DNA replication origin binding|inhibition of ARS binding|inhibition of DNA replication origin binding|negative regulation of ARS binding http://purl.obolibrary.org/obo/GO_1902596 gocheck_do_not_annotate GO:0035320 biolink:BiologicalProcess imaginal disc-derived wing hair site selection Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally. go.json prehair localization|wing hair site selection http://purl.obolibrary.org/obo/GO_0035320 GO:0035321 biolink:BiologicalProcess maintenance of imaginal disc-derived wing hair orientation Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity. go.json maintenance of wing hair orientation http://purl.obolibrary.org/obo/GO_0035321 GO:0035322 biolink:BiologicalProcess mesenchymal cell migration involved in limb bud formation The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud. go.json http://purl.obolibrary.org/obo/GO_0035322 GO:0035323 biolink:CellularComponent male germline ring canal An intercellular bridge that connects the germline cells of a male cyst. go.json spermatocyte ring canal|testicular ring canal http://purl.obolibrary.org/obo/GO_0035323 GO:0035324 biolink:CellularComponent female germline ring canal An intercellular bridge that connects the germline cells of a female cyst. go.json nurse cell ring canal|ovarian ring canal http://purl.obolibrary.org/obo/GO_0035324 GO:0035325 biolink:MolecularActivity Toll-like receptor binding Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. go.json TLR binding http://purl.obolibrary.org/obo/GO_0035325 GO:0035326 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035326 GO:0035327 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035327 GO:0098989 biolink:BiologicalProcess NMDA selective glutamate receptor signaling pathway The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json http://purl.obolibrary.org/obo/GO_0098989 GO:0098987 biolink:BiologicalProcess regulation of modification of synapse structure, modulating synaptic transmission Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0098987 goslim_synapse GO:0098988 biolink:MolecularActivity G protein-coupled glutamate receptor activity Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. go.json G-protein coupled glutamate receptor activity http://purl.obolibrary.org/obo/GO_0098988 GO:0098985 biolink:CellularComponent asymmetric, glutamatergic, excitatory synapse A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials. go.json http://purl.obolibrary.org/obo/GO_0098985 GO:0098986 biolink:CellularComponent T-bar A T-shaped presynpatic density. These are common in arhropod central nervous systems. go.json http://purl.obolibrary.org/obo/GO_0098986 GO:0098994 biolink:BiologicalProcess disruption of host cell envelope during viral entry The disruption of host cell envelope by viral proteins during virus entry. VZ:3938 go.json http://purl.obolibrary.org/obo/GO_0098994 GO:0098995 biolink:BiologicalProcess disruption by virus of host envelope lipopolysaccharide during virus entry The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides. VZ:3939 go.json degradation of host cell envelope lipopolysaccharide during viral entry|degradation of host lipopolysaccharide during virus entry|disassembly by virus of outer membrane lipopolysaccharide during viral entry http://purl.obolibrary.org/obo/GO_0098995 GO:0098992 biolink:CellularComponent neuronal dense core vesicle A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. go.json http://purl.obolibrary.org/obo/GO_0098992 goslim_synapse GO:0098993 biolink:CellularComponent obsolete anchored component of synaptic vesicle membrane OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json True http://purl.obolibrary.org/obo/GO_0098993 GO:0098990 biolink:BiologicalProcess AMPA selective glutamate receptor signaling pathway The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json http://purl.obolibrary.org/obo/GO_0098990 goslim_synapse GO:0098991 biolink:BiologicalProcess kainate selective glutamate receptor signaling pathway The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription. go.json http://purl.obolibrary.org/obo/GO_0098991 goslim_synapse GO:0035317 biolink:BiologicalProcess imaginal disc-derived wing hair organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster. go.json imaginal disc-derived wing hair organization and biogenesis|wing hair organisation|wing hair organization and biogenesis|wing trichome organization and biogenesis http://purl.obolibrary.org/obo/GO_0035317 GO:0035318 biolink:BiologicalProcess imaginal disc-derived wing hair outgrowth Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair. go.json wing hair outgrowth|wing prehair outgrowth http://purl.obolibrary.org/obo/GO_0035318 GO:0035319 biolink:BiologicalProcess imaginal disc-derived wing hair elongation Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles. go.json wing hair elongation|wing prehair extension http://purl.obolibrary.org/obo/GO_0035319 GO:0035310 biolink:BiologicalProcess notum cell fate specification The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment. go.json http://purl.obolibrary.org/obo/GO_0035310 GO:0035311 biolink:BiologicalProcess wing cell fate specification The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment. go.json http://purl.obolibrary.org/obo/GO_0035311 GO:0035312 biolink:MolecularActivity 5'-3' DNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. go.json 5'-3' exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0035312 GO:0035313 biolink:BiologicalProcess wound healing, spreading of epidermal cells The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. go.json http://purl.obolibrary.org/obo/GO_0035313 GO:0035314 biolink:BiologicalProcess scab formation Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection. go.json http://purl.obolibrary.org/obo/GO_0035314 GO:0035315 biolink:BiologicalProcess hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hair cell. go.json http://purl.obolibrary.org/obo/GO_0035315 GO:0035316 biolink:BiologicalProcess non-sensory hair organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis. go.json non-sensory hair organization and biogenesis|trichome organisation|trichome organization and biogenesis http://purl.obolibrary.org/obo/GO_0035316 GO:0098998 biolink:CellularComponent extrinsic component of postsynaptic early endosome membrane The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098998 goslim_synapse GO:0098999 biolink:CellularComponent extrinsic component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098999 goslim_synapse GO:0098996 biolink:BiologicalProcess disruption of host cell glycocalyx during viral entry The disruption of host cell glycocalyx by viral proteins during virus entry. VZ:3938 go.json catabolism of host glycocalyx during viral entry|degradation of host capsule during virus entry|degradation of host glycocalyx during viral entry|disassembly of glycocalyx during viral entry http://purl.obolibrary.org/obo/GO_0098996 GO:0098997 biolink:BiologicalProcess fusion of virus membrane with host outer membrane Fusion of a viral membrane with the host cell outer membrane during viral entry. VZ:3941 go.json fusion of viral membrane with host outer membrane|viral envelope fusion|viral envelope fusion with host outer membrane|viral penetration via membrane fusion|viral-cell fusion molecule activity http://purl.obolibrary.org/obo/GO_0098997 GO:0050940 biolink:BiologicalProcess regulation of late stripe melanocyte differentiation Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation. go.json regulation of late stripe melanophore differentiation http://purl.obolibrary.org/obo/GO_0050940 GO:0050943 biolink:BiologicalProcess negative regulation of iridophore differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation. go.json down regulation of iridophore differentiation|down-regulation of iridophore differentiation|downregulation of iridophore differentiation|inhibition of iridophore differentiation http://purl.obolibrary.org/obo/GO_0050943 GO:0050944 biolink:BiologicalProcess negative regulation of xanthophore differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation. go.json down regulation of xanthophore differentiation|down-regulation of xanthophore differentiation|downregulation of xanthophore differentiation|inhibition of xanthophore differentiation http://purl.obolibrary.org/obo/GO_0050944 GO:0050941 biolink:BiologicalProcess negative regulation of pigment cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. go.json down regulation of pigment cell differentiation|down-regulation of pigment cell differentiation|downregulation of pigment cell differentiation|inhibition of pigment cell differentiation http://purl.obolibrary.org/obo/GO_0050941 GO:0050942 biolink:BiologicalProcess positive regulation of pigment cell differentiation Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. go.json activation of pigment cell differentiation|stimulation of pigment cell differentiation|up regulation of pigment cell differentiation|up-regulation of pigment cell differentiation|upregulation of pigment cell differentiation http://purl.obolibrary.org/obo/GO_0050942 GO:0050947 biolink:BiologicalProcess negative regulation of early stripe melanocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation. go.json down regulation of early stripe melanocyte differentiation|down-regulation of early stripe melanocyte differentiation|downregulation of early stripe melanocyte differentiation|inhibition of early stripe melanocyte differentiation|negative regulation of early stripe melanophore differentiation http://purl.obolibrary.org/obo/GO_0050947 GO:0050948 biolink:BiologicalProcess positive regulation of early stripe melanocyte differentiation Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation. go.json activation of early stripe melanocyte differentiation|positive regulation of early stripe melanophore differentiation|stimulation of early stripe melanocyte differentiation|up regulation of early stripe melanocyte differentiation|up-regulation of early stripe melanocyte differentiation|upregulation of early stripe melanocyte differentiation http://purl.obolibrary.org/obo/GO_0050948 GO:0050945 biolink:BiologicalProcess positive regulation of iridophore differentiation Any process that activates or increases the frequency, rate or extent of iridophore differentiation. go.json activation of iridophore differentiation|stimulation of iridophore differentiation|up regulation of iridophore differentiation|up-regulation of iridophore differentiation|upregulation of iridophore differentiation http://purl.obolibrary.org/obo/GO_0050945 GO:0050946 biolink:BiologicalProcess positive regulation of xanthophore differentiation Any process that activates or increases the frequency, rate or extent of xanthophore differentiation. go.json activation of xanthophore differentiation|stimulation of xanthophore differentiation|up regulation of xanthophore differentiation|up-regulation of xanthophore differentiation|upregulation of xanthophore differentiation http://purl.obolibrary.org/obo/GO_0050946 GO:0050949 biolink:BiologicalProcess negative regulation of late stripe melanocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation. go.json down regulation of late stripe melanocyte differentiation|down-regulation of late stripe melanocyte differentiation|downregulation of late stripe melanocyte differentiation|inhibition of late stripe melanocyte differentiation|negative regulation of late stripe melanophore differentiation http://purl.obolibrary.org/obo/GO_0050949 GO:2001152 biolink:BiologicalProcess negative regulation of renal water transport Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport. go.json http://purl.obolibrary.org/obo/GO_2001152 GO:2001153 biolink:BiologicalProcess positive regulation of renal water transport Any process that activates or increases the frequency, rate or extent of renal water transport. go.json http://purl.obolibrary.org/obo/GO_2001153 GO:2001154 biolink:BiologicalProcess regulation of glycolytic fermentation to ethanol Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol. go.json regulation of ethanol fermentation|regulation of glucose fermentation to ethanol http://purl.obolibrary.org/obo/GO_2001154 GO:2001155 biolink:BiologicalProcess negative regulation of glycolytic fermentation to ethanol Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol. go.json negative regulation of ethanol fermentation|negative regulation of glucose fermentation to ethanol http://purl.obolibrary.org/obo/GO_2001155 GO:2001156 biolink:BiologicalProcess regulation of proline catabolic process to glutamate Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate. go.json regulation of proline breakdown to glutamate|regulation of proline degradation to glutamate|regulation of proline oxidation http://purl.obolibrary.org/obo/GO_2001156 GO:2001157 biolink:BiologicalProcess negative regulation of proline catabolic process to glutamate Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate. go.json negative regulation of proline breakdown to glutamate|negative regulation of proline degradation to glutamate|negative regulation of proline oxidation http://purl.obolibrary.org/obo/GO_2001157 GO:2001158 biolink:BiologicalProcess positive regulation of proline catabolic process to glutamate Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate. go.json positive regulation of proline breakdown to glutamate|positive regulation of proline degradation to glutamate|positive regulation of proline oxidation http://purl.obolibrary.org/obo/GO_2001158 GO:2001159 biolink:BiologicalProcess regulation of protein localization by the Cvt pathway Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway. go.json regulation of cytoplasm to vacuole targeting|regulation of cytoplasm-to-vacuole targeting http://purl.obolibrary.org/obo/GO_2001159 GO:2001150 biolink:BiologicalProcess positive regulation of dipeptide transmembrane transport Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport. go.json positive regulation of dipeptide membrane transport http://purl.obolibrary.org/obo/GO_2001150 GO:2001151 biolink:BiologicalProcess regulation of renal water transport Any process that modulates the frequency, rate or extent of renal water transport. go.json http://purl.obolibrary.org/obo/GO_2001151 GO:0050950 biolink:BiologicalProcess positive regulation of late stripe melanocyte differentiation Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation. go.json activation of late stripe melanocyte differentiation|positive regulation of late stripe melanophore differentiation|stimulation of late stripe melanocyte differentiation|up regulation of late stripe melanocyte differentiation|up-regulation of late stripe melanocyte differentiation|upregulation of late stripe melanocyte differentiation http://purl.obolibrary.org/obo/GO_0050950 GO:0050951 biolink:BiologicalProcess sensory perception of temperature stimulus The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json sensory perception of thermal stimulus http://purl.obolibrary.org/obo/GO_0050951 GO:0050954 biolink:BiologicalProcess sensory perception of mechanical stimulus The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json chemi-mechanical coupling|mechanosensory perception|perception of mechanical stimulus http://purl.obolibrary.org/obo/GO_0050954 GO:0050955 biolink:BiologicalProcess thermoception The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). Wikipedia:Thermoception go.json thermoreception http://purl.obolibrary.org/obo/GO_0050955 GO:0050952 biolink:BiologicalProcess sensory perception of electrical stimulus The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json http://purl.obolibrary.org/obo/GO_0050952 GO:0050953 biolink:BiologicalProcess sensory perception of light stimulus The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json http://purl.obolibrary.org/obo/GO_0050953 GO:0050958 biolink:BiologicalProcess magnetoreception The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light. Wikipedia:Magnetoception go.json magnetoception|sensory perception of magnetic field http://purl.obolibrary.org/obo/GO_0050958 GO:0050959 biolink:BiologicalProcess echolocation Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning. Wikipedia:Echolocation go.json biological sonar|perception of environment using reflected sound waves http://purl.obolibrary.org/obo/GO_0050959 GO:0050956 biolink:BiologicalProcess electroception The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. Wikipedia:Electroreception go.json electroception sense|electroceptive sense http://purl.obolibrary.org/obo/GO_0050956 GO:0050957 biolink:BiologicalProcess equilibrioception The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. Wikipedia:Equilibrioception go.json sensory perception of orientation with respect to gravity http://purl.obolibrary.org/obo/GO_0050957 GO:2001163 biolink:BiologicalProcess obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues OBSOLETE. Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. go.json True http://purl.obolibrary.org/obo/GO_2001163 GO:2001164 biolink:BiologicalProcess obsolete negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. go.json True http://purl.obolibrary.org/obo/GO_2001164 GO:2001165 biolink:BiologicalProcess obsolete positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. go.json True http://purl.obolibrary.org/obo/GO_2001165 GO:2001166 biolink:BiologicalProcess regulation of histone H2B ubiquitination Any process that modulates the frequency, rate or extent of histone H2B ubiquitination. go.json http://purl.obolibrary.org/obo/GO_2001166 GO:2001167 biolink:BiologicalProcess obsolete negative regulation of histone H2B ubiquitination OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination. go.json True http://purl.obolibrary.org/obo/GO_2001167 GO:2001168 biolink:BiologicalProcess positive regulation of histone H2B ubiquitination Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination. go.json http://purl.obolibrary.org/obo/GO_2001168 GO:2001169 biolink:BiologicalProcess regulation of ATP biosynthetic process Any process that modulates the frequency, rate or extent of ATP biosynthetic process. go.json regulation of ATP anabolism|regulation of ATP biosynthesis|regulation of ATP formation|regulation of ATP regeneration|regulation of ATP synthesis http://purl.obolibrary.org/obo/GO_2001169 GO:2001160 biolink:BiologicalProcess obsolete regulation of histone H3-K79 methylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K79 methylation. go.json regulation of histone H3 K79 methylation|regulation of histone H3K79me|regulation of histone lysine H3 K79 methylation True http://purl.obolibrary.org/obo/GO_2001160 GO:2001161 biolink:BiologicalProcess obsolete negative regulation of histone H3-K79 methylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation. go.json negative regulation of histone H3 K79 methylation|negative regulation of histone H3K79me|negative regulation of histone lysine H3 K79 methylation True http://purl.obolibrary.org/obo/GO_2001161 GO:2001162 biolink:BiologicalProcess obsolete positive regulation of histone H3-K79 methylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation. go.json positive regulation of histone H3 K79 methylation|positive regulation of histone H3K79me|positive regulation of histone lysine H3 K79 methylation True http://purl.obolibrary.org/obo/GO_2001162 GO:0050961 biolink:BiologicalProcess detection of temperature stimulus involved in sensory perception The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. go.json sensory detection of heat stimulus during sensory perception|sensory detection of temperature stimulus|sensory detection of temperature stimulus during sensory perception|sensory detection of thermal stimulus during sensory perception|sensory perception, sensory detection of heat stimulus|sensory perception, sensory detection of temperature stimulus|sensory perception, sensory detection of thermal stimulus|sensory perception, sensory transduction of heat stimulus|sensory perception, sensory transduction of temperature stimulus|sensory perception, sensory transduction of thermal stimulus|sensory transduction of heat stimulus during sensory perception|sensory transduction of temperature stimulus|sensory transduction of temperature stimulus during sensory perception|sensory transduction of thermal stimulus during sensory perception http://purl.obolibrary.org/obo/GO_0050961 GO:0050962 biolink:BiologicalProcess detection of light stimulus involved in sensory perception The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. go.json sensory detection of light stimulus|sensory detection of light stimulus during sensory perception|sensory perception, sensory detection of light stimulus|sensory perception, sensory transduction of light stimulus|sensory transduction of light stimulus|sensory transduction of light stimulus during sensory perception http://purl.obolibrary.org/obo/GO_0050962 GO:0050960 biolink:BiologicalProcess detection of temperature stimulus involved in thermoception The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception. go.json sensory detection of temperature stimulus during thermoception|sensory detection of thermal stimulus during thermoception|sensory transduction of temperature stimulus during thermoception|sensory transduction of thermal stimulus during thermoception|thermoception, sensory detection of temperature stimulus|thermoception, sensory detection of thermal stimulus|thermoception, sensory transduction of temperature stimulus|thermoception, sensory transduction of thermal stimulus http://purl.obolibrary.org/obo/GO_0050960 GO:0050965 biolink:BiologicalProcess detection of temperature stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. go.json perception of pain, detection of temperature stimulus|perception of pain, sensory detection of temperature stimulus|perception of pain, sensory transduction of temperature stimulus|sensory detection of temperature stimulus during perception of pain|sensory detection of thermal stimulus during sensory perception of pain|sensory perception of pain, sensory detection of thermal stimulus|sensory perception of pain, sensory transduction of thermal stimulus|sensory transduction of temperature stimulus during perception of pain|sensory transduction of thermal stimulus during sensory perception of pain|thermal nociception http://purl.obolibrary.org/obo/GO_0050965 GO:0050966 biolink:BiologicalProcess detection of mechanical stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. go.json mechanical nociception|perception of pain, detection of mechanical stimulus|perception of pain, sensory detection of mechanical stimulus|perception of pain, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during perception of pain|sensory transduction of mechanical stimulus during perception of pain http://purl.obolibrary.org/obo/GO_0050966 GO:0050963 biolink:BiologicalProcess detection of electrical stimulus involved in sensory perception The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. go.json sensory detection of electrical stimulus|sensory detection of electrical stimulus during sensory perception|sensory perception, sensory detection of electrical stimulus|sensory perception, sensory transduction of electrical stimulus|sensory transduction of electrical stimulus|sensory transduction of electrical stimulus during sensory perception http://purl.obolibrary.org/obo/GO_0050963 GO:0050964 biolink:BiologicalProcess detection of electrical stimulus involved in electroception The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. go.json detection of electrical stimulus during electroreception|electroception, detection of electrical stimulus|electroception, sensory detection of electrical stimulus|electroception, sensory transduction|electroception, sensory transduction of electrical stimulus|sensory detection of electrical stimulus during electroception|sensory transduction of electrical stimulus during electroception http://purl.obolibrary.org/obo/GO_0050964 GO:0050969 biolink:BiologicalProcess detection of chemical stimulus involved in magnetoreception The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states. go.json magnetoception, sensory transduction of chemical stimulus|magnetoreception, detection of chemical stimulus|magnetoreception, sensory detection of chemical stimulus|magnetoreception, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during magnetoreception|sensory transduction of chemical stimulus during magnetoreception http://purl.obolibrary.org/obo/GO_0050969 GO:0050967 biolink:BiologicalProcess detection of electrical stimulus involved in sensory perception of pain The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. go.json detection of electrical stimulus during sensory perception of pain|perception of pain, detection of electrical stimulus|perception of pain, sensory detection of electrical stimulus|perception of pain, sensory transduction of electrical stimulus|sensory detection of electrical stimulus during perception of pain|sensory transduction of electrical stimulus during perception of pain http://purl.obolibrary.org/obo/GO_0050967 GO:0050968 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. go.json chemical nociception|perception of pain, detection of chemical stimulus|perception of pain, sensory detection of chemical stimulus|perception of pain, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during perception of pain|sensory transduction of chemical stimulus during perception of pain http://purl.obolibrary.org/obo/GO_0050968 GO:2001174 biolink:BiologicalProcess obsolete negative regulation of histone H2B conserved C-terminal lysine ubiquitination OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. go.json negative regulation of budding yeast H2B K123 ubiquitination|negative regulation of fission yeast H2B K119 ubiquitination|negative regulation of mammalian H2B K120 ubiquitination True http://purl.obolibrary.org/obo/GO_2001174 GO:2001175 biolink:BiologicalProcess obsolete positive regulation of histone H2B conserved C-terminal lysine ubiquitination OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. go.json positive regulation of budding yeast H2B K123 ubiquitination|positive regulation of fission yeast H2B K119 ubiquitination|positive regulation of mammalian H2B K120 ubiquitination True http://purl.obolibrary.org/obo/GO_2001175 GO:2001176 biolink:BiologicalProcess regulation of mediator complex assembly Any process that modulates the frequency, rate or extent of mediator complex assembly. go.json http://purl.obolibrary.org/obo/GO_2001176 GO:2001177 biolink:BiologicalProcess negative regulation of mediator complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly. go.json http://purl.obolibrary.org/obo/GO_2001177 GO:2001178 biolink:BiologicalProcess positive regulation of mediator complex assembly Any process that activates or increases the frequency, rate or extent of mediator complex assembly. go.json http://purl.obolibrary.org/obo/GO_2001178 GO:2001179 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001179 GO:2001170 biolink:BiologicalProcess negative regulation of ATP biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process. go.json negative regulation of ATP anabolism|negative regulation of ATP biosynthesis|negative regulation of ATP formation|negative regulation of ATP regeneration|negative regulation of ATP synthesis http://purl.obolibrary.org/obo/GO_2001170 GO:2001171 biolink:BiologicalProcess positive regulation of ATP biosynthetic process Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process. go.json positive regulation of ATP anabolism|positive regulation of ATP biosynthesis|positive regulation of ATP formation|positive regulation of ATP regeneration|positive regulation of ATP synthesis http://purl.obolibrary.org/obo/GO_2001171 GO:2001172 biolink:BiologicalProcess positive regulation of glycolytic fermentation to ethanol Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol. go.json positive regulation of ethanol fermentation|positive regulation of glucose fermentation to ethanol http://purl.obolibrary.org/obo/GO_2001172 GO:2001173 biolink:BiologicalProcess regulation of histone H2B conserved C-terminal lysine ubiquitination Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. go.json regulation of budding yeast H2B K123 ubiquitination|regulation of fission yeast H2B K119 ubiquitination|regulation of mammalian H2B K120 ubiquitination http://purl.obolibrary.org/obo/GO_2001173 GO:0050972 biolink:BiologicalProcess detection of mechanical stimulus involved in echolocation The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave. go.json echolocation, detection of mechanical stimulus|echolocation, sensory detection of mechanical stimulus|echolocation, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during echolocation|sensory transduction of mechanical stimulus during echolocation http://purl.obolibrary.org/obo/GO_0050972 GO:0050973 biolink:BiologicalProcess detection of mechanical stimulus involved in equilibrioception The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears. go.json equilibrioception, detection of mechanical stimulus|equilibrioception, sensory detection of mechanical stimulus|equilibrioception, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during equilibrioception|sensory transduction of mechanical stimulus during equilibrioception http://purl.obolibrary.org/obo/GO_0050973 GO:0050970 biolink:BiologicalProcess detection of electrical stimulus involved in magnetoreception The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field. go.json detection of electrical stimulus during magnetoreception|magnetoception, sensory transduction of electrical stimulus|magnetoreception, detection of electrical stimulus|magnetoreception, sensory detection of electrical stimulus|magnetoreception, sensory transduction of electrical stimulus|sensory detection of electrical stimulus during magnetoreception|sensory transduction of electrical stimulus during magnetoreception http://purl.obolibrary.org/obo/GO_0050970 GO:0050971 biolink:BiologicalProcess detection of mechanical stimulus involved in magnetoreception The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field. go.json magnetoception, sensory transduction of mechanical stimulus|magnetoreception, detection of mechanical stimulus|magnetoreception, sensory detection of mechanical stimulus|magnetoreception, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during magnetoreception|sensory transduction of mechanical stimulus during magnetoreception http://purl.obolibrary.org/obo/GO_0050971 GO:0050976 biolink:BiologicalProcess detection of mechanical stimulus involved in sensory perception of touch The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal. go.json perception of touch, detection of mechanical stimulus|perception of touch, sensory detection of mechanical stimulus|perception of touch, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during perception of touch|sensory transduction of mechanical stimulus during perception of touch|tactition, sensory detection of mechanical stimulus http://purl.obolibrary.org/obo/GO_0050976 GO:0050977 biolink:BiologicalProcess magnetoreception by sensory perception of chemical stimulus The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli. go.json magnetoreception by chemical stimulus|magnetoreception through chemical stimulus|magnetoreception, sensory perception of chemical stimulus|magnetoreception, using chemical stimulus http://purl.obolibrary.org/obo/GO_0050977 GO:0050974 biolink:BiologicalProcess detection of mechanical stimulus involved in sensory perception The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. go.json sensory detection of mechanical stimulus|sensory detection of mechanical stimulus during sensory perception|sensory perception, sensory detection of mechanical stimulus|sensory perception, sensory transduction of mechanical stimulus|sensory transduction of mechanical stimulus|sensory transduction of mechanical stimulus during sensory perception http://purl.obolibrary.org/obo/GO_0050974 GO:0050975 biolink:BiologicalProcess sensory perception of touch The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). Wikipedia:Touch go.json perception of touch|tactile sense|taction|tactition http://purl.obolibrary.org/obo/GO_0050975 GO:0050978 biolink:BiologicalProcess magnetoreception by sensory perception of electrical stimulus The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish. go.json magnetoreception by electrical stimulus|magnetoreception through electrical stimulus|magnetoreception, sensory perception of electrical stimulus|magnetoreception, using electrical stimulus http://purl.obolibrary.org/obo/GO_0050978 GO:0050979 biolink:BiologicalProcess magnetoreception by sensory perception of mechanical stimulus The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field. go.json magnetoreception through mechanical stimulus|magnetoreception, sensory perception of mechanical stimulus|magnetoreception, using mechanical stimulus http://purl.obolibrary.org/obo/GO_0050979 GO:2001185 biolink:BiologicalProcess regulation of CD8-positive, alpha-beta T cell activation Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. go.json http://purl.obolibrary.org/obo/GO_2001185 GO:2001186 biolink:BiologicalProcess negative regulation of CD8-positive, alpha-beta T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. go.json http://purl.obolibrary.org/obo/GO_2001186 GO:2001187 biolink:BiologicalProcess positive regulation of CD8-positive, alpha-beta T cell activation Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. go.json http://purl.obolibrary.org/obo/GO_2001187 GO:2001188 biolink:BiologicalProcess regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. go.json regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell http://purl.obolibrary.org/obo/GO_2001188 GO:2001189 biolink:BiologicalProcess negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. go.json negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell http://purl.obolibrary.org/obo/GO_2001189 GO:2001180 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001180 GO:2001181 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001181 GO:2001182 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001182 GO:2001183 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001183 GO:2001184 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_2001184 GO:0050983 biolink:BiologicalProcess obsolete deoxyhypusine biosynthetic process from spermidine OBSOLETE. The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+. go.json deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase|deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase|deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase|deoxyhypusine formation from spermidine, using deoxyhypusine synthase|spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|spermidine degradation to deoxyhypusine, using deoxyhypusine synthase True http://purl.obolibrary.org/obo/GO_0050983 GO:0050984 biolink:BiologicalProcess peptidyl-serine sulfation The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine. RESID:AA0361 go.json http://purl.obolibrary.org/obo/GO_0050984 gocheck_do_not_annotate GO:0050981 biolink:BiologicalProcess detection of electrical stimulus The series of events by which an electrical stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0050981 GO:0050982 biolink:BiologicalProcess detection of mechanical stimulus The series of events by which a mechanical stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0050982 GO:0050987 biolink:BiologicalProcess obsolete enzyme active site formation via O-sulfo-L-serine OBSOLETE. The transient sulfation of peptidyl-serine to form O-sulfo-L-serine. RESID:AA0361 go.json True http://purl.obolibrary.org/obo/GO_0050987 GO:0050988 biolink:BiologicalProcess N-terminal peptidyl-methionine carboxylation The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine. RESID:AA0363 go.json http://purl.obolibrary.org/obo/GO_0050988 gocheck_do_not_annotate GO:0050985 biolink:BiologicalProcess peptidyl-threonine sulfation The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine. RESID:AA0362 go.json http://purl.obolibrary.org/obo/GO_0050985 gocheck_do_not_annotate GO:0050986 biolink:BiologicalProcess isopeptide cross-linking via N-(L-isoglutamyl)-glycine The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25. RESID:AA0360 go.json http://purl.obolibrary.org/obo/GO_0050986 gocheck_do_not_annotate GO:2001116 biolink:BiologicalProcess methanopterin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a methanopterin. go.json methanopterin biosynthesis http://purl.obolibrary.org/obo/GO_2001116 GO:2001117 biolink:BiologicalProcess tetrahydromethanopterin metabolic process The chemical reactions and pathways involving a tetrahydromethanopterin. go.json tetrahydromethanopterin metabolism http://purl.obolibrary.org/obo/GO_2001117 GO:0050989 biolink:BiologicalProcess N-terminal protein amino acid carboxylation The carboxylation of the N-terminal amino acid of proteins. go.json http://purl.obolibrary.org/obo/GO_0050989 gocheck_do_not_annotate GO:2001118 biolink:BiologicalProcess tetrahydromethanopterin biosynthetic process The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin. go.json tetrahydromethanopterin biosynthesis http://purl.obolibrary.org/obo/GO_2001118 GO:2001119 biolink:BiologicalProcess methanofuran metabolic process The chemical reactions and pathways involving a methanofuran. go.json methanofuran metabolism http://purl.obolibrary.org/obo/GO_2001119 GO:0060310 biolink:BiologicalProcess regulation of elastin catabolic process Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. go.json regulation of elastin breakdown|regulation of elastin catabolism|regulation of elastin degradation http://purl.obolibrary.org/obo/GO_0060310 GO:0060311 biolink:BiologicalProcess negative regulation of elastin catabolic process Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. go.json down-regulation of elastin catabolic process|negative regulation of elastin breakdown|negative regulation of elastin catabolism|negative regulation of elastin degradation http://purl.obolibrary.org/obo/GO_0060311 GO:2001110 biolink:BiologicalProcess negative regulation of lens epithelial cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2001110 GO:0060312 biolink:BiologicalProcess regulation of blood vessel remodeling Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. go.json regulation of blood vessel remodelling http://purl.obolibrary.org/obo/GO_0060312 GO:2001111 biolink:BiologicalProcess positive regulation of lens epithelial cell proliferation Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_2001111 GO:0098929 biolink:CellularComponent obsolete extrinsic component of spine apparatus membrane OBSOLETE. The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json True http://purl.obolibrary.org/obo/GO_0098929 GO:2001112 biolink:BiologicalProcess regulation of cellular response to hepatocyte growth factor stimulus Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. go.json regulation of cellular response to HGF stimulus http://purl.obolibrary.org/obo/GO_2001112 GO:0060313 biolink:BiologicalProcess negative regulation of blood vessel remodeling Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. go.json down-regulation of blood vessel remodeling|inhibition of blood vessel remodeling|negative regulation of blood vessel remodelling http://purl.obolibrary.org/obo/GO_0060313 GO:2001113 biolink:BiologicalProcess negative regulation of cellular response to hepatocyte growth factor stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. go.json negative regulation of cellular response to HGF stimulus http://purl.obolibrary.org/obo/GO_2001113 GO:0060314 biolink:BiologicalProcess regulation of ryanodine-sensitive calcium-release channel activity Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0060314 gocheck_do_not_annotate GO:2001114 biolink:BiologicalProcess positive regulation of cellular response to hepatocyte growth factor stimulus Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. go.json positive regulation of cellular response to HGF stimulus http://purl.obolibrary.org/obo/GO_2001114 GO:0060315 biolink:BiologicalProcess negative regulation of ryanodine-sensitive calcium-release channel activity Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0060315 gocheck_do_not_annotate GO:0098927 biolink:BiologicalProcess vesicle-mediated transport between endosomal compartments A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. go.json http://purl.obolibrary.org/obo/GO_0098927 GO:0060316 biolink:BiologicalProcess positive regulation of ryanodine-sensitive calcium-release channel activity Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0060316 gocheck_do_not_annotate GO:0098928 biolink:BiologicalProcess presynaptic signal transduction Signal transduction in which the initial step occurs in a presynapse. go.json presynaptic signaling pathway http://purl.obolibrary.org/obo/GO_0098928 goslim_synapse GO:2001115 biolink:BiologicalProcess methanopterin-containing compound metabolic process The chemical reactions and pathways involving a methanopterin. go.json methanopterin metabolism http://purl.obolibrary.org/obo/GO_2001115 GO:0098925 biolink:BiologicalProcess retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. go.json http://purl.obolibrary.org/obo/GO_0098925 goslim_synapse GO:0060317 biolink:BiologicalProcess cardiac epithelial to mesenchymal transition A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json heart epithelial to mesenchymal transition http://purl.obolibrary.org/obo/GO_0060317 GO:0098926 biolink:BiologicalProcess postsynaptic signal transduction Signal transduction in which the initial step occurs in a postsynapse. go.json postsynaptic signaling pathway http://purl.obolibrary.org/obo/GO_0098926 goslim_synapse GO:0060318 biolink:BiologicalProcess definitive erythrocyte differentiation Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis. go.json definitive RBC differentiation|definitive erythropoiesis|definitive red blood cell differentiation http://purl.obolibrary.org/obo/GO_0060318 GO:0060319 biolink:BiologicalProcess primitive erythrocyte differentiation Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis. go.json primitive RBC differentiation|primitive erythropoiesis|primitive red blood cell differentiation http://purl.obolibrary.org/obo/GO_0060319 GO:0098923 biolink:BiologicalProcess retrograde trans-synaptic signaling by soluble gas Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand. go.json http://purl.obolibrary.org/obo/GO_0098923 goslim_synapse GO:0098924 biolink:BiologicalProcess retrograde trans-synaptic signaling by nitric oxide Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. go.json http://purl.obolibrary.org/obo/GO_0098924 goslim_synapse GO:0098921 biolink:BiologicalProcess retrograde trans-synaptic signaling by endocannabinoid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand. go.json http://purl.obolibrary.org/obo/GO_0098921 goslim_synapse GO:0050980 biolink:BiologicalProcess detection of light stimulus involved in magnetoreception The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field. go.json magnetoreception, detection of light stimulus|magnetoreception, sensory detection of light stimulus|magnetoreception, sensory transduction of light stimulus|sensory detection of light stimulus during magnetoreception|sensory transduction of light stimulus during magnetoreception http://purl.obolibrary.org/obo/GO_0050980 GO:0098922 biolink:CellularComponent extrinsic component of dense core granule membrane The component of the dense core granule membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json http://purl.obolibrary.org/obo/GO_0098922 GO:0098920 biolink:BiologicalProcess retrograde trans-synaptic signaling by lipid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. go.json http://purl.obolibrary.org/obo/GO_0098920 goslim_synapse GO:0050994 biolink:BiologicalProcess regulation of lipid catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. go.json regulation of lipid breakdown|regulation of lipid catabolism|regulation of lipid degradation http://purl.obolibrary.org/obo/GO_0050994 GO:0050995 biolink:BiologicalProcess negative regulation of lipid catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. go.json down regulation of lipid catabolic process|down-regulation of lipid catabolic process|downregulation of lipid catabolic process|inhibition of lipid catabolic process|negative regulation of lipid breakdown|negative regulation of lipid catabolism|negative regulation of lipid degradation http://purl.obolibrary.org/obo/GO_0050995 GO:1902508 biolink:CellularComponent 2-iminoacetate synthase complex A protein complex which is capable of 2-iminoacetate synthase activity. go.json ThiH-ThiG complex http://purl.obolibrary.org/obo/GO_1902508 GO:0050992 biolink:BiologicalProcess dimethylallyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate. go.json DPP biosynthesis|DPP biosynthetic process|dimethylallyl diphosphate anabolism|dimethylallyl diphosphate biosynthesis|dimethylallyl diphosphate formation|dimethylallyl diphosphate synthesis|dimethylallyl pyrophosphate biosynthesis|dimethylallyl pyrophosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0050992 GO:0050993 biolink:BiologicalProcess dimethylallyl diphosphate metabolic process The chemical reactions and pathways involving dimethylallyl diphosphate. go.json DPP metabolic process|DPP metabolism|dimethylallyl diphosphate metabolism|dimethylallyl pyrophosphate metabolic process|dimethylallyl pyrophosphate metabolism http://purl.obolibrary.org/obo/GO_0050993 GO:1902509 biolink:CellularComponent methionine-importing complex A protein complex which is capable of methionine-importing activity. go.json methionine importer complex|methionine importing complex http://purl.obolibrary.org/obo/GO_1902509 GO:0050998 biolink:MolecularActivity nitric-oxide synthase binding Binding to nitric-oxide synthase. go.json NOS binding http://purl.obolibrary.org/obo/GO_0050998 GO:1902506 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902506 GO:0050999 biolink:BiologicalProcess regulation of nitric-oxide synthase activity Any process that modulates the activity of the enzyme nitric-oxide synthase. go.json NOS regulator|nitric-oxide synthase regulator|regulation of NOS activity http://purl.obolibrary.org/obo/GO_0050999 gocheck_do_not_annotate GO:1902507 biolink:CellularComponent thiazole synthase complex A protein complex which is capable of thiazole synthase activity. go.json http://purl.obolibrary.org/obo/GO_1902507 GO:1902504 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902504 GO:0050996 biolink:BiologicalProcess positive regulation of lipid catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. go.json activation of lipid catabolic process|positive regulation of lipid breakdown|positive regulation of lipid catabolism|positive regulation of lipid degradation|stimulation of lipid catabolic process|up regulation of lipid catabolic process|up-regulation of lipid catabolic process|upregulation of lipid catabolic process http://purl.obolibrary.org/obo/GO_0050996 GO:0050997 biolink:MolecularActivity quaternary ammonium group binding Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. go.json quaternary amine binding http://purl.obolibrary.org/obo/GO_0050997 GO:1902505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902505 GO:2001127 biolink:BiologicalProcess methane biosynthetic process from formic acid The chemical reactions and pathways resulting in the formation of a methane from a formic acid. go.json http://purl.obolibrary.org/obo/GO_2001127 GO:1902502 biolink:CellularComponent multivesicular body HOPS complex Any HOPS complex that is part of a multivesicular body membrane. go.json multivesicular body membrane HOPS complex http://purl.obolibrary.org/obo/GO_1902502 GO:2001128 biolink:BiologicalProcess methane biosynthetic process from methylamine The chemical reactions and pathways resulting in the formation of a methane from a methylamine. go.json http://purl.obolibrary.org/obo/GO_2001128 GO:1902503 biolink:CellularComponent adenylyltransferase complex A protein complex which is capable of adenylyltransferase activity. go.json ThiF-ThiS complex http://purl.obolibrary.org/obo/GO_1902503 GO:1902500 biolink:CellularComponent vacuolar HOPS complex Any HOPS complex that is part of a vacuolar membrane. go.json vacuolar membrane HOPS complex http://purl.obolibrary.org/obo/GO_1902500 GO:2001129 biolink:BiologicalProcess methane biosynthetic process from dimethylamine The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine. go.json http://purl.obolibrary.org/obo/GO_2001129 GO:1902501 biolink:CellularComponent lysosomal HOPS complex Any HOPS complex that is part of a lysosomal membrane. go.json lysosomal membrane HOPS complex http://purl.obolibrary.org/obo/GO_1902501 GO:2001120 biolink:BiologicalProcess methanofuran biosynthetic process The chemical reactions and pathways resulting in the formation of a methanofuran. go.json methanofuran biosynthesis http://purl.obolibrary.org/obo/GO_2001120 GO:2001121 biolink:BiologicalProcess coenzyme gamma-F420-2 biosynthetic process The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2. go.json coenzyme gamma-F420-2 biosynthesis http://purl.obolibrary.org/obo/GO_2001121 GO:0060300 biolink:BiologicalProcess regulation of cytokine activity Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. go.json http://purl.obolibrary.org/obo/GO_0060300 gocheck_do_not_annotate GO:2001122 biolink:BiologicalProcess maltoheptaose metabolic process The chemical reactions and pathways involving a maltoheptaose. go.json maltoheptaose metabolism http://purl.obolibrary.org/obo/GO_2001122 GO:0060301 biolink:BiologicalProcess positive regulation of cytokine activity Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. go.json http://purl.obolibrary.org/obo/GO_0060301 gocheck_do_not_annotate GO:2001123 biolink:BiologicalProcess maltoheptaose catabolic process The chemical reactions and pathways resulting in the breakdown of a maltoheptaose. go.json maltoheptaose catabolism http://purl.obolibrary.org/obo/GO_2001123 GO:0060302 biolink:BiologicalProcess negative regulation of cytokine activity Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. go.json http://purl.obolibrary.org/obo/GO_0060302 gocheck_do_not_annotate GO:0060303 biolink:BiologicalProcess obsolete regulation of nucleosome density OBSOLETE. Any process that modulates the number of nucleosomes in a given region of a chromosome. go.json True http://purl.obolibrary.org/obo/GO_0060303 GO:2001124 biolink:BiologicalProcess regulation of translational frameshifting Any process that modulates the frequency, rate or extent of translational frameshifting. go.json http://purl.obolibrary.org/obo/GO_2001124 GO:2001125 biolink:BiologicalProcess negative regulation of translational frameshifting Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting. go.json http://purl.obolibrary.org/obo/GO_2001125 GO:0060304 biolink:BiologicalProcess regulation of phosphatidylinositol dephosphorylation Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. go.json regulation of phosphoinositide dephosphorylation http://purl.obolibrary.org/obo/GO_0060304 GO:0098938 biolink:CellularComponent actin cytoskeleton of dendritic spine The actin cytoskeleton that is part of a dendritic spine. go.json http://purl.obolibrary.org/obo/GO_0098938 goslim_synapse GO:0098939 biolink:BiologicalProcess dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell dendrites. go.json http://purl.obolibrary.org/obo/GO_0098939 goslim_synapse GO:2001126 biolink:BiologicalProcess positive regulation of translational frameshifting Any process that activates or increases the frequency, rate or extent of translational frameshifting. go.json http://purl.obolibrary.org/obo/GO_2001126 GO:0060305 biolink:BiologicalProcess regulation of cell diameter Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell. go.json regulation of cell width http://purl.obolibrary.org/obo/GO_0060305 GO:0098936 biolink:CellularComponent obsolete intrinsic component of postsynaptic membrane OBSOLETE. The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to postsynaptic membrane True http://purl.obolibrary.org/obo/GO_0098936 GO:0060306 biolink:BiologicalProcess regulation of membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. go.json http://purl.obolibrary.org/obo/GO_0060306 GO:0060307 biolink:BiologicalProcess regulation of ventricular cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. go.json electrocardiogram T wave|regulation of ventricular cardiac muscle cell repolarization|regulation of ventricular cardiac muscle repolarization|regulation of ventricular cardiomyocyte membrane repolarization|ventricular repolarization http://purl.obolibrary.org/obo/GO_0060307 GO:0098937 biolink:BiologicalProcess anterograde dendritic transport The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites. go.json http://purl.obolibrary.org/obo/GO_0098937 goslim_synapse GO:0060308 biolink:MolecularActivity GTP cyclohydrolase I regulator activity Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. go.json http://purl.obolibrary.org/obo/GO_0060308 GO:0098934 biolink:BiologicalProcess retrograde dendritic transport The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body. go.json http://purl.obolibrary.org/obo/GO_0098934 goslim_synapse GO:0060309 biolink:BiologicalProcess elastin catabolic process The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. go.json elastin breakdown|elastin catabolism|elastin degradation http://purl.obolibrary.org/obo/GO_0060309 GO:0098935 biolink:BiologicalProcess dendritic transport The directed movement of organelles or molecules along microtubules in dendrites. go.json dendrite cargo transport http://purl.obolibrary.org/obo/GO_0098935 goslim_synapse GO:0098932 biolink:BiologicalProcess disruption by virus of host cell wall peptidoglycan during virus entry A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry. VZ:3940 go.json catabolism of host cell wall peptidoglycan by virus|degradation of host cell wall peptidoglycan by virus|degradation of host peptidoglycans during virus entry|disassembly by virus of host cell wall peptidoglycan http://purl.obolibrary.org/obo/GO_0098932 GO:0050990 biolink:BiologicalProcess N-terminal protein amino acid carbamoylation The carbamoylation of the N-terminal amino acid of proteins. go.json N-terminal protein amino acid carbamylation http://purl.obolibrary.org/obo/GO_0050990 gocheck_do_not_annotate GO:0050991 biolink:BiologicalProcess obsolete enzyme active site formation via O-sulfo-L-threonine OBSOLETE. The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine. RESID:AA0362 go.json True http://purl.obolibrary.org/obo/GO_0050991 GO:0098933 biolink:BiologicalProcess symbiont-mediated disruption of host cell envelope The process in which an organism effects a change that impairs the structure or function of the host cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host cell envelope http://purl.obolibrary.org/obo/GO_0098933 GO:0098930 biolink:BiologicalProcess axonal transport The directed movement of organelles or molecules along microtubules in axons. Wikipedia:Axoplasmic_transport go.json axon cargo transport|axoplasmic transport http://purl.obolibrary.org/obo/GO_0098930 goslim_synapse GO:0098931 biolink:BiologicalProcess virion attachment to host cell flagellum The process by which a virion attaches to a the host cell flagellum. Some DNA bacterial viruses use flagella to attach to the host cell. This contact with the flagellum facilitates concentration of phage particles around the entry receptor on the bacterial cell surface. VZ:3949 go.json http://purl.obolibrary.org/obo/GO_0098931 GO:1902519 biolink:BiologicalProcess response to docetaxel trihydrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus. go.json response to docetaxel http://purl.obolibrary.org/obo/GO_1902519 gocheck_do_not_manually_annotate GO:1902517 biolink:CellularComponent glycerol-3-phosphate-transporting ATPase complex A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity. go.json http://purl.obolibrary.org/obo/GO_1902517 GO:1902518 biolink:BiologicalProcess response to cyclophosphamide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus. go.json http://purl.obolibrary.org/obo/GO_1902518 gocheck_do_not_manually_annotate GO:1902515 biolink:CellularComponent thioredoxin-disulfide reductase complex A protein complex which is capable of thioredoxin-disulfide reductase activity. go.json http://purl.obolibrary.org/obo/GO_1902515 GO:1902516 biolink:MolecularActivity sn-glycerol 3-phosphate binding Binding to sn-glycerol 3-phosphate. go.json http://purl.obolibrary.org/obo/GO_1902516 GO:1902513 biolink:BiologicalProcess regulation of organelle transport along microtubule Any process that modulates the frequency, rate or extent of organelle transport along microtubule. go.json regulation of microtubule-based organelle localization http://purl.obolibrary.org/obo/GO_1902513 GO:2001138 biolink:BiologicalProcess regulation of phospholipid transport Any process that modulates the frequency, rate or extent of phospholipid transport. go.json http://purl.obolibrary.org/obo/GO_2001138 GO:2001139 biolink:BiologicalProcess negative regulation of phospholipid transport Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport. go.json http://purl.obolibrary.org/obo/GO_2001139 GO:1902514 biolink:BiologicalProcess regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. go.json regulation of generation of L-type calcium current http://purl.obolibrary.org/obo/GO_1902514 GO:1902511 biolink:BiologicalProcess negative regulation of apoptotic DNA fragmentation Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. go.json down regulation of DNA catabolic process during apoptosis|down regulation of DNA catabolism during apoptosis|down regulation of DNA fragmentation involved in apoptotic nuclear change|down regulation of apoptotic DNA fragmentation|down regulation of endonucleolytic DNA catabolic process involved in apoptosis|down-regulation of DNA catabolic process during apoptosis|down-regulation of DNA catabolism during apoptosis|down-regulation of DNA fragmentation involved in apoptotic nuclear change|down-regulation of apoptotic DNA fragmentation|down-regulation of endonucleolytic DNA catabolic process involved in apoptosis|downregulation of DNA catabolic process during apoptosis|downregulation of DNA catabolism during apoptosis|downregulation of DNA fragmentation involved in apoptotic nuclear change|downregulation of apoptotic DNA fragmentation|downregulation of endonucleolytic DNA catabolic process involved in apoptosis|inhibition of DNA catabolic process during apoptosis|inhibition of DNA catabolism during apoptosis|inhibition of DNA fragmentation involved in apoptotic nuclear change|inhibition of apoptotic DNA fragmentation|inhibition of endonucleolytic DNA catabolic process involved in apoptosis|negative regulation of DNA catabolic process during apoptosis|negative regulation of DNA catabolism during apoptosis|negative regulation of DNA fragmentation involved in apoptotic nuclear change|negative regulation of endonucleolytic DNA catabolic process involved in apoptosis http://purl.obolibrary.org/obo/GO_1902511 GO:1902512 biolink:BiologicalProcess positive regulation of apoptotic DNA fragmentation Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. go.json activation of DNA catabolic process during apoptosis|activation of DNA catabolism during apoptosis|activation of DNA fragmentation involved in apoptotic nuclear change|activation of apoptotic DNA fragmentation|activation of endonucleolytic DNA catabolic process involved in apoptosis|positive regulation of DNA catabolic process during apoptosis|positive regulation of DNA catabolism during apoptosis|positive regulation of DNA fragmentation involved in apoptotic nuclear change|positive regulation of endonucleolytic DNA catabolic process involved in apoptosis|up regulation of DNA catabolic process during apoptosis|up regulation of DNA catabolism during apoptosis|up regulation of DNA fragmentation involved in apoptotic nuclear change|up regulation of apoptotic DNA fragmentation|up regulation of endonucleolytic DNA catabolic process involved in apoptosis|up-regulation of DNA catabolic process during apoptosis|up-regulation of DNA catabolism during apoptosis|up-regulation of DNA fragmentation involved in apoptotic nuclear change|up-regulation of apoptotic DNA fragmentation|up-regulation of endonucleolytic DNA catabolic process involved in apoptosis|upregulation of DNA catabolic process during apoptosis|upregulation of DNA catabolism during apoptosis|upregulation of DNA fragmentation involved in apoptotic nuclear change|upregulation of apoptotic DNA fragmentation|upregulation of endonucleolytic DNA catabolic process involved in apoptosis http://purl.obolibrary.org/obo/GO_1902512 GO:1902510 biolink:BiologicalProcess regulation of apoptotic DNA fragmentation Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. go.json regulation of DNA catabolic process during apoptosis|regulation of DNA catabolism during apoptosis|regulation of DNA fragmentation|regulation of DNA fragmentation involved in apoptotic nuclear change|regulation of chromatinolysis|regulation of endonucleolytic DNA catabolic process involved in apoptosis http://purl.obolibrary.org/obo/GO_1902510 GO:0060330 biolink:BiologicalProcess regulation of response to type II interferon Any process that modulates the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. go.json regulation of response to gamma-interferon|regulation of response to immune interferon|regulation of response to interferon-gamma|regulation of response to type II IFN http://purl.obolibrary.org/obo/GO_0060330 GO:2001130 biolink:BiologicalProcess methane biosynthetic process from trimethylamine The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine. go.json http://purl.obolibrary.org/obo/GO_2001130 GO:0060331 biolink:BiologicalProcess negative regulation of response to type II interferon Any process that decreases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. go.json negative regulation of response to gamma-interferon|negative regulation of response to immune interferon|negative regulation of response to interferon-gamma|negative regulation of response to type II IFN http://purl.obolibrary.org/obo/GO_0060331 GO:0060332 biolink:BiologicalProcess positive regulation of response to type II interferon Any process that increases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. go.json positive regulation of response to gamma-interferon|positive regulation of response to immune interferon|positive regulation of response to interferon-gamma|positive regulation of response to type II IFN http://purl.obolibrary.org/obo/GO_0060332 GO:2001131 biolink:BiologicalProcess methane biosynthetic process from dimethyl sulfide The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide. go.json http://purl.obolibrary.org/obo/GO_2001131 GO:2001132 biolink:BiologicalProcess methane biosynthetic process from 3-(methylthio)propionic acid The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid. go.json http://purl.obolibrary.org/obo/GO_2001132 GO:0098909 biolink:BiologicalProcess regulation of cardiac muscle cell action potential involved in regulation of contraction Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction. go.json http://purl.obolibrary.org/obo/GO_0098909 GO:0060333 biolink:BiologicalProcess type II interferon-mediated signaling pathway The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. go.json gamma-interferon-mediated signaling pathway|immune interferon signaling pathway|interferon-gamma-mediated signaling pathway|interferon-gamma-mediated signalling pathway|type II IFN-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0060333 GO:2001133 biolink:BiologicalProcess methane biosynthetic process from methanethiol The chemical reactions and pathways resulting in the formation of a methane from a methanethiol. go.json http://purl.obolibrary.org/obo/GO_2001133 GO:0060334 biolink:BiologicalProcess regulation of type II interferon-mediated signaling pathway Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. go.json regulation of gamma-interferon-mediated signaling pathway|regulation of immune interferon signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signalling pathway|regulation of type II IFN-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0060334 GO:2001134 biolink:BiologicalProcess methane biosynthetic process from carbon monoxide The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide. go.json http://purl.obolibrary.org/obo/GO_2001134 GO:0098907 biolink:BiologicalProcess regulation of SA node cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json regulation of SA node cardiac muscle cell action potential|regulation of SAN cardiac muscle cell action potential|regulation of sinoatrial node cardiac muscle cell action potential|regulation of sinus node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0098907 GO:0060335 biolink:BiologicalProcess positive regulation of type II interferon-mediated signaling pathway Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. go.json positive regulation of gamma-interferon-mediated signaling pathway|positive regulation of immune interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of interferon-gamma-mediated signalling pathway|positive regulation of type II IFN-mediated pathway http://purl.obolibrary.org/obo/GO_0060335 GO:0098908 biolink:BiologicalProcess regulation of neuronal action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json generation of action potential http://purl.obolibrary.org/obo/GO_0098908 GO:0060336 biolink:BiologicalProcess negative regulation of type II interferon-mediated signaling pathway Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. go.json negative regulation of gamma-interferon-mediated signaling pathway|negative regulation of immune interferon-mediated signaling pathway|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of interferon-gamma-mediated signalling pathway|negative regulation of type II IFN-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0060336 GO:2001135 biolink:BiologicalProcess regulation of endocytic recycling Any process that modulates the frequency, rate or extent of endocytic recycling. go.json regulation of retrograde transport of endocytic vesicles http://purl.obolibrary.org/obo/GO_2001135 GO:0098905 biolink:BiologicalProcess regulation of bundle of His cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json regulation of bundle of His cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0098905 GO:2001136 biolink:BiologicalProcess negative regulation of endocytic recycling Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling. go.json negative regulation of retrograde transport of endocytic vesicles http://purl.obolibrary.org/obo/GO_2001136 GO:0060337 biolink:BiologicalProcess type I interferon-mediated signaling pathway The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json type I interferon signaling pathway|type I interferon-activated signaling pathway http://purl.obolibrary.org/obo/GO_0060337 GO:0060338 biolink:BiologicalProcess regulation of type I interferon-mediated signaling pathway Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. go.json regulation of type I interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0060338 GO:2001137 biolink:BiologicalProcess positive regulation of endocytic recycling Any process that activates or increases the frequency, rate or extent of endocytic recycling. go.json positive regulation of retrograde transport of endocytic vesicles http://purl.obolibrary.org/obo/GO_2001137 GO:0098906 biolink:BiologicalProcess regulation of Purkinje myocyte action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json http://purl.obolibrary.org/obo/GO_0098906 GO:0060339 biolink:BiologicalProcess negative regulation of type I interferon-mediated signaling pathway Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. go.json negative regulation of type I interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0060339 GO:0098903 biolink:BiologicalProcess regulation of membrane repolarization during action potential Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential. go.json http://purl.obolibrary.org/obo/GO_0098903 GO:0098904 biolink:BiologicalProcess regulation of AV node cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json regulation of AV node cardiac muscle cell action potential|regulation of atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0098904 GO:0098901 biolink:BiologicalProcess regulation of cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json http://purl.obolibrary.org/obo/GO_0098901 GO:0098902 biolink:BiologicalProcess regulation of membrane depolarization during action potential Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential. go.json http://purl.obolibrary.org/obo/GO_0098902 GO:0098900 biolink:BiologicalProcess regulation of action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json http://purl.obolibrary.org/obo/GO_0098900 GO:1902528 biolink:BiologicalProcess regulation of protein linear polyubiquitination Any process that modulates the frequency, rate or extent of protein linear polyubiquitination. go.json regulation of M1 linkage http://purl.obolibrary.org/obo/GO_1902528 GO:1902529 biolink:BiologicalProcess negative regulation of protein linear polyubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination. go.json down regulation of M1 linkage|down regulation of protein linear polyubiquitination|down-regulation of M1 linkage|down-regulation of protein linear polyubiquitination|downregulation of M1 linkage|downregulation of protein linear polyubiquitination|inhibition of M1 linkage|inhibition of protein linear polyubiquitination|negative regulation of M1 linkage http://purl.obolibrary.org/obo/GO_1902529 GO:1902526 biolink:BiologicalProcess negative regulation of protein monoubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination. go.json down regulation of protein monoubiquitination|down regulation of protein monoubiquitinylation|down regulation of protein monoubiquitylation|down-regulation of protein monoubiquitination|down-regulation of protein monoubiquitinylation|down-regulation of protein monoubiquitylation|downregulation of protein monoubiquitination|downregulation of protein monoubiquitinylation|downregulation of protein monoubiquitylation|inhibition of protein monoubiquitination|inhibition of protein monoubiquitinylation|inhibition of protein monoubiquitylation|negative regulation of protein monoubiquitinylation|negative regulation of protein monoubiquitylation http://purl.obolibrary.org/obo/GO_1902526 GO:1902527 biolink:BiologicalProcess positive regulation of protein monoubiquitination Any process that activates or increases the frequency, rate or extent of protein monoubiquitination. go.json activation of protein monoubiquitination|activation of protein monoubiquitinylation|activation of protein monoubiquitylation|positive regulation of protein monoubiquitinylation|positive regulation of protein monoubiquitylation|up regulation of protein monoubiquitination|up regulation of protein monoubiquitinylation|up regulation of protein monoubiquitylation|up-regulation of protein monoubiquitination|up-regulation of protein monoubiquitinylation|up-regulation of protein monoubiquitylation|upregulation of protein monoubiquitination|upregulation of protein monoubiquitinylation|upregulation of protein monoubiquitylation http://purl.obolibrary.org/obo/GO_1902527 GO:2001149 biolink:BiologicalProcess negative regulation of dipeptide transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport. go.json negative regulation of dipeptide membrane transport http://purl.obolibrary.org/obo/GO_2001149 GO:1902524 biolink:BiologicalProcess positive regulation of protein K48-linked ubiquitination Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination. go.json activation of protein K48-linked polyubiquitination|activation of protein K48-linked ubiquitination|positive regulation of protein K48-linked polyubiquitination|up regulation of protein K48-linked polyubiquitination|up regulation of protein K48-linked ubiquitination|up-regulation of protein K48-linked polyubiquitination|up-regulation of protein K48-linked ubiquitination|upregulation of protein K48-linked polyubiquitination|upregulation of protein K48-linked ubiquitination http://purl.obolibrary.org/obo/GO_1902524 GO:1902525 biolink:BiologicalProcess regulation of protein monoubiquitination Any process that modulates the frequency, rate or extent of protein monoubiquitination. go.json regulation of protein monoubiquitinylation|regulation of protein monoubiquitylation http://purl.obolibrary.org/obo/GO_1902525 GO:1902522 biolink:BiologicalProcess response to 4'-epidoxorubicin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus. go.json response to epirubicin http://purl.obolibrary.org/obo/GO_1902522 gocheck_do_not_manually_annotate GO:1902523 biolink:BiologicalProcess positive regulation of protein K63-linked ubiquitination Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination. go.json activation of protein K63-linked polyubiquitination|activation of protein K63-linked ubiquitination|positive regulation of protein K63-linked polyubiquitination|up regulation of protein K63-linked polyubiquitination|up regulation of protein K63-linked ubiquitination|up-regulation of protein K63-linked polyubiquitination|up-regulation of protein K63-linked ubiquitination|upregulation of protein K63-linked polyubiquitination|upregulation of protein K63-linked ubiquitination http://purl.obolibrary.org/obo/GO_1902523 GO:1902520 biolink:BiologicalProcess response to doxorubicin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus. go.json http://purl.obolibrary.org/obo/GO_1902520 gocheck_do_not_manually_annotate GO:1902521 biolink:BiologicalProcess response to etoposide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus. go.json http://purl.obolibrary.org/obo/GO_1902521 gocheck_do_not_manually_annotate GO:0060320 biolink:BiologicalProcess rejection of self pollen The recognition and rejection of self pollen by cells in the stigma, mediated by the sharing and interaction of the single locus incompatibility haplotypes. go.json self-incompatibility http://purl.obolibrary.org/obo/GO_0060320 GO:2001141 biolink:BiologicalProcess regulation of RNA biosynthetic process Any process that modulates the frequency, rate or extent of RNA biosynthetic process. go.json regulation of RNA anabolism|regulation of RNA biosynthesis|regulation of RNA formation|regulation of RNA synthesis http://purl.obolibrary.org/obo/GO_2001141 GO:0035397 biolink:BiologicalProcess helper T cell enhancement of adaptive immune response Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell. go.json provision of T cell help http://purl.obolibrary.org/obo/GO_0035397 GO:0035398 biolink:BiologicalProcess helper T cell enhancement of T cell mediated immune response Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell. go.json helper T cell enhancement of T cell mediated immunity|provision of T cell help to T cell http://purl.obolibrary.org/obo/GO_0035398 GO:0060321 biolink:BiologicalProcess acceptance of pollen The recognition and acceptance of pollen by cells in the stigma, mediated by the sharing and interaction of the single locus incompatibility haplotypes. go.json acceptance of non-self pollen|acceptance of self pollen|self-compatibility http://purl.obolibrary.org/obo/GO_0060321 GO:2001142 biolink:BiologicalProcess nicotinate transport The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001142 GO:0035399 biolink:BiologicalProcess helper T cell enhancement of B cell mediated immune response Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell. go.json helper T cell enhancement of B cell mediated immunity|provision of T cell help to B cell http://purl.obolibrary.org/obo/GO_0035399 GO:2001143 biolink:BiologicalProcess N-methylnicotinate transport The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_2001143 GO:0060322 biolink:BiologicalProcess head development The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. go.json http://purl.obolibrary.org/obo/GO_0060322 GO:2001144 biolink:BiologicalProcess regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_2001144 gocheck_do_not_annotate GO:0060323 biolink:BiologicalProcess head morphogenesis The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. go.json http://purl.obolibrary.org/obo/GO_0060323 GO:0098918 biolink:MolecularActivity structural constituent of synapse The action of a molecule that contributes to the structural integrity of a synapse. go.json http://purl.obolibrary.org/obo/GO_0098918 goslim_synapse GO:0060324 biolink:BiologicalProcess face development The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. go.json http://purl.obolibrary.org/obo/GO_0060324 GO:2001145 biolink:BiologicalProcess negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_2001145 gocheck_do_not_annotate GO:0098919 biolink:MolecularActivity structural constituent of postsynaptic density The action of a molecule that contributes to the structural integrity of a postsynaptic density. go.json http://purl.obolibrary.org/obo/GO_0098919 goslim_synapse GO:2001146 biolink:BiologicalProcess positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_2001146 gocheck_do_not_annotate GO:0060325 biolink:BiologicalProcess face morphogenesis The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. go.json http://purl.obolibrary.org/obo/GO_0060325 GO:2001147 biolink:MolecularActivity camalexin binding Binding to camalexin. go.json 3-(1,3-thiazol-2-yl)-1H-indole binding http://purl.obolibrary.org/obo/GO_2001147 GO:0098916 biolink:BiologicalProcess anterograde trans-synaptic signaling Cell-cell signaling from pre to post-synapse, across the synaptic cleft. go.json http://purl.obolibrary.org/obo/GO_0098916 GO:0060326 biolink:BiologicalProcess cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). go.json http://purl.obolibrary.org/obo/GO_0060326 GO:0098917 biolink:BiologicalProcess retrograde trans-synaptic signaling Cell-cell signaling from post to pre-synapse, across the synaptic cleft. go.json http://purl.obolibrary.org/obo/GO_0098917 GO:2001148 biolink:BiologicalProcess regulation of dipeptide transmembrane transport Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport. go.json regulation of dipeptide membrane transport http://purl.obolibrary.org/obo/GO_2001148 GO:0060327 biolink:BiologicalProcess cytoplasmic actin-based contraction involved in cell motility The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another. go.json http://purl.obolibrary.org/obo/GO_0060327 GO:0060328 biolink:BiologicalProcess cytoplasmic actin-based contraction involved in forward cell motility The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell. go.json cytoplasmic actin-based contraction involved in forward cell locomotion http://purl.obolibrary.org/obo/GO_0060328 GO:0098914 biolink:BiologicalProcess membrane repolarization during atrial cardiac muscle cell action potential The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json atrial repolarization|electrocardiogram QRS complex http://purl.obolibrary.org/obo/GO_0098914 GO:0060329 biolink:BiologicalProcess cytoplasmic actin-based contraction involved in rearward cell motility The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell. go.json cytoplasmic actin-based contraction involved in rearward cell locomotion http://purl.obolibrary.org/obo/GO_0060329 GO:0098915 biolink:BiologicalProcess membrane repolarization during ventricular cardiac muscle cell action potential The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json electrocardiogram T wave|regulation of ventricular cardiac muscle repolarization|ventricular repolarization http://purl.obolibrary.org/obo/GO_0098915 GO:0035390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0035390 GO:0035391 biolink:BiologicalProcess obsolete maintenance of chromatin silencing at silent mating-type cassette OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci. go.json True http://purl.obolibrary.org/obo/GO_0035391 GO:0098912 biolink:BiologicalProcess membrane depolarization during atrial cardiac muscle cell action potential The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json atrial cardiac muscle cell depolarization|atrial depolarization|electrocardiogram PR interval http://purl.obolibrary.org/obo/GO_0098912 GO:0035392 biolink:BiologicalProcess obsolete maintenance of chromatin silencing at telomere OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere. go.json True http://purl.obolibrary.org/obo/GO_0035392 GO:0098913 biolink:BiologicalProcess membrane depolarization during ventricular cardiac muscle cell action potential The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json electrocardiogram QRS complex|ventricular depolarization http://purl.obolibrary.org/obo/GO_0098913 GO:0035393 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 9 production The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL9 production|MIG production|Monokine induced by gamma interferon production http://purl.obolibrary.org/obo/GO_0035393 gocheck_do_not_annotate GO:0098910 biolink:BiologicalProcess regulation of atrial cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json http://purl.obolibrary.org/obo/GO_0098910 GO:0035394 biolink:BiologicalProcess regulation of chemokine (C-X-C motif) ligand 9 production Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9. go.json regulation of CXCL9 production|regulation of MIG production http://purl.obolibrary.org/obo/GO_0035394 GO:0098911 biolink:BiologicalProcess regulation of ventricular cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. go.json http://purl.obolibrary.org/obo/GO_0098911 GO:0035395 biolink:BiologicalProcess negative regulation of chemokine (C-X-C motif) ligand 9 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9. go.json negative regulation of CXCL9 production|negative regulation of MIG production http://purl.obolibrary.org/obo/GO_0035395 GO:0035396 biolink:BiologicalProcess positive regulation of chemokine (C-X-C motif) ligand 9 production Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9. go.json positive regulation of CXCL9 production|positive regulation of MIG production http://purl.obolibrary.org/obo/GO_0035396 GO:2001140 biolink:BiologicalProcess positive regulation of phospholipid transport Any process that activates or increases the frequency, rate or extent of phospholipid transport. go.json http://purl.obolibrary.org/obo/GO_2001140 GO:0015098 biolink:MolecularActivity molybdate ion transmembrane transporter activity Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. go.json molybdate transporter activity http://purl.obolibrary.org/obo/GO_0015098 GO:0015099 biolink:MolecularActivity nickel cation transmembrane transporter activity Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. RHEA:29831 go.json zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity http://purl.obolibrary.org/obo/GO_0015099 GO:0015094 biolink:MolecularActivity lead ion transmembrane transporter activity Enables the transfer of lead (Pb) ions from one side of a membrane to the other. go.json zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity http://purl.obolibrary.org/obo/GO_0015094 GO:0015095 biolink:MolecularActivity magnesium ion transmembrane transporter activity Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. RHEA:29827|Reactome:R-HSA-442661|Reactome:R-HSA-5336453|Reactome:R-HSA-5336454|Reactome:R-HSA-5336466|Reactome:R-HSA-5339528|Reactome:R-HSA-5339538 go.json http://purl.obolibrary.org/obo/GO_0015095 GO:0015096 biolink:MolecularActivity obsolete manganese resistance permease activity OBSOLETE. This term was not defined before being made obsolete. go.json manganese resistance permease activity True http://purl.obolibrary.org/obo/GO_0015096 GO:0015097 biolink:MolecularActivity mercury ion transmembrane transporter activity Enables the transfer of mercury (Hg) ions from one side of a membrane to the other. RHEA:32815 go.json http://purl.obolibrary.org/obo/GO_0015097 GO:0015080 biolink:MolecularActivity silver ion transmembrane transporter activity Enables the transfer of silver (Ag) ions from one side of a membrane to the other. go.json silver transporter activity http://purl.obolibrary.org/obo/GO_0015080 GO:0015081 biolink:MolecularActivity sodium ion transmembrane transporter activity Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. RHEA:34963 go.json sodium transporter activity http://purl.obolibrary.org/obo/GO_0015081 GO:0015082 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015082 GO:0015076 biolink:MolecularActivity obsolete heavy metal ion transporter activity OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. go.json heavy metal ion transporter activity True http://purl.obolibrary.org/obo/GO_0015076 GO:0015077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015077 GO:0015078 biolink:MolecularActivity proton transmembrane transporter activity Enables the transfer of a proton from one side of a membrane to the other. Reactome:R-HSA-1222516|Reactome:R-HSA-164834|Reactome:R-HSA-168313|Reactome:R-HSA-170026|Reactome:R-HSA-74723|Reactome:R-HSA-917841 go.json hydrogen ion transmembrane transporter activity|proton transporter activity http://purl.obolibrary.org/obo/GO_0015078 GO:0015079 biolink:MolecularActivity potassium ion transmembrane transporter activity Enables the transfer of potassium ions (K+) from one side of a membrane to the other. RHEA:29463 go.json potassium transporter activity|potassium uptake permease activity|potassium uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015079 GO:0015072 biolink:MolecularActivity obsolete phosphatidylinositol 3-kinase, class I, catalyst activity OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. go.json phosphatidylinositol 3-kinase, class I, catalyst activity True http://purl.obolibrary.org/obo/GO_0015072 GO:0015073 biolink:MolecularActivity obsolete phosphatidylinositol 3-kinase, class I, regulator activity OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. go.json phosphatidylinositol 3-kinase, class I, regulator activity True http://purl.obolibrary.org/obo/GO_0015073 GO:0015074 biolink:BiologicalProcess DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. go.json http://purl.obolibrary.org/obo/GO_0015074 goslim_pir GO:0015075 biolink:MolecularActivity monoatomic ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other. go.json ion transmembrane transporter activity|ion transporter activity http://purl.obolibrary.org/obo/GO_0015075 GO:0015090 biolink:MolecularActivity low-affinity ferric iron ion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity iron ion transmembrane transporter activity|low affinity iron transporter activity http://purl.obolibrary.org/obo/GO_0015090 GO:0015091 biolink:MolecularActivity ferric iron transmembrane transporter activity Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015091 GO:0015092 biolink:MolecularActivity high-affinity ferric iron transmembrane transporter activity Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity ferric uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015092 GO:0015093 biolink:MolecularActivity ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. RHEA:28486|Reactome:R-HSA-1362417|Reactome:R-HSA-442368|Reactome:R-HSA-5655760 go.json ferrous iron uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015093 GO:0015087 biolink:MolecularActivity cobalt ion transmembrane transporter activity Enables the transfer of cobalt (Co) ions from one side of a membrane to the other. RHEA:28578 go.json cobalt, zinc uptake permease activity|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity http://purl.obolibrary.org/obo/GO_0015087 GO:0015088 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015088 GO:0015089 biolink:MolecularActivity high-affinity copper ion transmembrane transporter activity Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity copper ion transmembrane transporter activity|high affinity copper transporter activity http://purl.obolibrary.org/obo/GO_0015089 GO:0015083 biolink:MolecularActivity aluminum ion transmembrane transporter activity Enables the transfer of aluminum (Al) ions from one side of a membrane to the other. go.json aluminium ion transporter activity|aluminium resistance permease activity|aluminum resistance permease activity http://purl.obolibrary.org/obo/GO_0015083 GO:0015084 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015084 GO:0015085 biolink:MolecularActivity calcium ion transmembrane transporter activity Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. RHEA:29671|Reactome:R-HSA-2534359 go.json http://purl.obolibrary.org/obo/GO_0015085 GO:0015086 biolink:MolecularActivity cadmium ion transmembrane transporter activity Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. go.json zinc, cadmium uptake permease activity|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity http://purl.obolibrary.org/obo/GO_0015086 GO:0015060 biolink:MolecularActivity obsolete green-sensitive opsin OBSOLETE. (Was not defined before being made obsolete). go.json green-sensitive opsin True http://purl.obolibrary.org/obo/GO_0015060 GO:0030699 biolink:MolecularActivity glycine reductase activity Catalysis of the reaction: acetyl phosphate + H2O + NH4 + thioredoxin disulfide = glycine + H+ + phosphate + thioredoxin. EC:1.21.4.2|KEGG_REACTION:R07226|MetaCyc:RXN-7566|RHEA:12232 go.json acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming) http://purl.obolibrary.org/obo/GO_0030699 GO:0030697 biolink:MolecularActivity tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.35|MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN|RHEA:42712 go.json M5U-methyltransferase activity|RUMT|RUMT activity|S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity|S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity|S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity|ribothymidyl synthase activity|tRNA (uracil(54)-C(5))-methyltransferase activity, S-adenosyl methionine-dependent|tRNA (uracil-5-)-methyltransferase activity|tRNA uracil 5-methyltransferase activity|tRNA:m(5)U54-methyltransferase activity|tRNA:m5U54-methyltransferase activity|transfer RNA uracil 5-methyltransferase activity|transfer RNA uracil methylase activity http://purl.obolibrary.org/obo/GO_0030697 GO:0030698 biolink:MolecularActivity obsolete 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity OBSOLETE. Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria. go.json RUMT True http://purl.obolibrary.org/obo/GO_0030698 GO:0015058 biolink:MolecularActivity obsolete epidermal growth factor-like module containing hormone receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json EGF-like module containing hormone receptor activity|Egr1 hormone receptor|epidermal growth factor-like module containing hormone receptor activity True http://purl.obolibrary.org/obo/GO_0015058 GO:0015059 biolink:MolecularActivity obsolete blue-sensitive opsin OBSOLETE. (Was not defined before being made obsolete). go.json blue-sensitive opsin True http://purl.obolibrary.org/obo/GO_0015059 GO:0039021 biolink:BiologicalProcess pronephric glomerulus development The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment. go.json http://purl.obolibrary.org/obo/GO_0039021 GO:0030695 biolink:MolecularActivity GTPase regulator activity Binds to and modulates the activity of a GTPase. go.json small GTPase regulator activity|small GTPase regulatory/interacting protein activity http://purl.obolibrary.org/obo/GO_0030695 GO:0015054 biolink:MolecularActivity gastrin receptor activity Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. go.json cholecystokinin-B receptor activity http://purl.obolibrary.org/obo/GO_0015054 GO:0030696 biolink:MolecularActivity obsolete tRNA (m5U54) methyltransferase activity OBSOLETE. Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule. go.json RUMT True http://purl.obolibrary.org/obo/GO_0030696 GO:0039022 biolink:BiologicalProcess pronephric duct development The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney. go.json http://purl.obolibrary.org/obo/GO_0039022 GO:0015055 biolink:MolecularActivity secretin receptor activity Combining with secretin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0015055 GO:0030693 biolink:MolecularActivity obsolete caspase activity OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. go.json caspase activity|caspase-1 activity|caspase-10 activity|caspase-2 activity|caspase-3 activity|caspase-4 activity|caspase-5 activity|caspase-6 activity|caspase-7 activity|caspase-8 activity|caspase-9 activity|effector caspase activity|signaling (initiator) caspase activity True http://purl.obolibrary.org/obo/GO_0030693 GO:0015056 biolink:MolecularActivity corticotrophin-releasing factor receptor activity Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0015056 GO:0030694 biolink:CellularComponent bacterial-type flagellum basal body, rod The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. go.json flagellar basal body, rod|flagellin-based flagellum basal body, rod http://purl.obolibrary.org/obo/GO_0030694 GO:0015057 biolink:MolecularActivity thrombin-activated receptor activity A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. go.json thrombin receptor activity|thrombin receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0015057 GO:0039020 biolink:BiologicalProcess pronephric nephron tubule development The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct. go.json http://purl.obolibrary.org/obo/GO_0039020 GO:0015050 biolink:CellularComponent methane monooxygenase complex A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized. go.json http://purl.obolibrary.org/obo/GO_0015050 GO:0030691 biolink:CellularComponent Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis. go.json http://purl.obolibrary.org/obo/GO_0030691 GO:0015051 biolink:MolecularActivity obsolete X-opioid receptor activity OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors. go.json X-opioid receptor activity True http://purl.obolibrary.org/obo/GO_0015051 GO:0030692 biolink:CellularComponent Noc4p-Nop14p complex A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. go.json Nop7 complex|Nop7 subcomplex http://purl.obolibrary.org/obo/GO_0030692 GO:0015052 biolink:MolecularActivity beta3-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. go.json beta3 adrenoceptor http://purl.obolibrary.org/obo/GO_0015052 GO:0039023 biolink:BiologicalProcess pronephric duct morphogenesis The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney. go.json http://purl.obolibrary.org/obo/GO_0039023 GO:0015053 biolink:MolecularActivity obsolete opsin OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin. go.json opsin True http://purl.obolibrary.org/obo/GO_0015053 GO:0030690 biolink:CellularComponent Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis. go.json http://purl.obolibrary.org/obo/GO_0030690 GO:0015070 biolink:MolecularActivity obsolete toxin activity OBSOLETE. Acts as to cause injury to other living organisms. go.json toxin activity True http://purl.obolibrary.org/obo/GO_0015070 GO:0015071 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015071 GO:0030688 biolink:CellularComponent preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. go.json 43S preribosome http://purl.obolibrary.org/obo/GO_0030688 GO:0030689 biolink:CellularComponent Noc complex Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis. go.json http://purl.obolibrary.org/obo/GO_0030689 goslim_pir GO:0030686 biolink:CellularComponent 90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. go.json http://purl.obolibrary.org/obo/GO_0030686 GO:0030687 biolink:CellularComponent preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. go.json 66S preribosome http://purl.obolibrary.org/obo/GO_0030687 GO:0039018 biolink:BiologicalProcess nephrostome development The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity. go.json http://purl.obolibrary.org/obo/GO_0039018 GO:0039019 biolink:BiologicalProcess pronephric nephron development The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros. go.json http://purl.obolibrary.org/obo/GO_0039019 GO:0039016 biolink:BiologicalProcess cell-cell signaling involved in pronephros development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ. go.json cell-cell signaling involved in pronephric kidney development|cell-cell signalling involved in pronephros development http://purl.obolibrary.org/obo/GO_0039016 GO:0039017 biolink:BiologicalProcess pattern specification involved in pronephros development Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate. go.json pattern specification involved in pronephric kidney development http://purl.obolibrary.org/obo/GO_0039017 GO:0015069 biolink:MolecularActivity scyllo-inosamine-4-phosphate amidinotransferase activity Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine. EC:2.1.4.2|KEGG_REACTION:R03477|MetaCyc:2.1.4.2-RXN|RHEA:13265 go.json L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity|L-arginine:inosamine phosphate amidinotransferase activity|L-arginine:inosamine-P-amidinotransferase activity|inosamine-P amidinotransferase activity|inosamine-phosphate amidinotransferase activity http://purl.obolibrary.org/obo/GO_0015069 GO:0030684 biolink:CellularComponent preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. go.json http://purl.obolibrary.org/obo/GO_0030684 goslim_pir GO:0039010 biolink:BiologicalProcess specification of pronephric distal tubule identity The process in which the distal tubule of the pronephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0039010 GO:0015065 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015065 GO:0015066 biolink:MolecularActivity alpha-amylase inhibitor activity Binds to and stops, prevents or reduces the activity of alpha-amylase. go.json http://purl.obolibrary.org/obo/GO_0015066 GO:0039011 biolink:BiologicalProcess pronephric proximal tubule morphogenesis The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. go.json pronephros proximal tubule morphogenesis http://purl.obolibrary.org/obo/GO_0039011 GO:0030685 biolink:CellularComponent nucleolar preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis. go.json http://purl.obolibrary.org/obo/GO_0030685 GO:0030682 biolink:BiologicalProcess perturbation of host defenses by symbiont A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json avoidance of defenses of other organism during symbiotic interaction|avoidance of defenses of other organism involved in symbiotic interaction|avoidance of host defences|avoidance of host defenses|evasion of host defence response|evasion of other organism defence response|evasion or tolerance of defense response of other organism during symbiotic interaction|evasion or tolerance of defense response of other organism involved in symbiotic interaction|evasion or tolerance of defenses of other organism|evasion or tolerance of defenses of other organism during symbiotic interaction|evasion or tolerance of defenses of other organism involved in symbiotic interaction|evasion or tolerance of host defense response|evasion or tolerance of host defenses|mitigation of host defenses by symbiont http://purl.obolibrary.org/obo/GO_0030682 GO:0015067 biolink:MolecularActivity amidinotransferase activity Catalysis of the reversible transfer of an amidino group to an acceptor. EC:2.1.4.- go.json transamidinase activity http://purl.obolibrary.org/obo/GO_0015067 GO:0015068 biolink:MolecularActivity glycine amidinotransferase activity Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. EC:2.1.4.1|MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN|RHEA:13201|Reactome:R-HSA-71275 go.json L-arginine:glycine amidinotransferase activity|arginine-glycine amidinotransferase activity|arginine-glycine transamidinase activity|glycine transamidinase activity http://purl.obolibrary.org/obo/GO_0015068 GO:0030683 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030683 GO:0030680 biolink:CellularComponent dimeric ribonuclease P complex A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species. go.json dimeric RNase P complex http://purl.obolibrary.org/obo/GO_0030680 GO:0015061 biolink:MolecularActivity obsolete red-sensitive opsin OBSOLETE. (Was not defined before being made obsolete). go.json red-sensitive opsin True http://purl.obolibrary.org/obo/GO_0015061 GO:0039014 biolink:BiologicalProcess cell differentiation involved in pronephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state. go.json cell differentiation involved in pronephric kidney development http://purl.obolibrary.org/obo/GO_0039014 GO:0015062 biolink:MolecularActivity obsolete violet-sensitive opsin OBSOLETE. (Was not defined before being made obsolete). go.json violet-sensitive opsin True http://purl.obolibrary.org/obo/GO_0015062 GO:0030681 biolink:CellularComponent multimeric ribonuclease P complex A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species. go.json multimeric RNase P complex http://purl.obolibrary.org/obo/GO_0030681 GO:0039015 biolink:BiologicalProcess cell proliferation involved in pronephros development The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros. go.json cell proliferation involved in pronephric kidney development http://purl.obolibrary.org/obo/GO_0039015 GO:0039012 biolink:BiologicalProcess pronephric sinus development The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules. go.json http://purl.obolibrary.org/obo/GO_0039012 GO:0015063 biolink:MolecularActivity obsolete long-wave-sensitive opsin OBSOLETE. An opsin with maximal absorption above 500 nm. go.json long-wave-sensitive opsin True http://purl.obolibrary.org/obo/GO_0015063 GO:0039013 biolink:BiologicalProcess pronephric distal tubule morphogenesis The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. go.json http://purl.obolibrary.org/obo/GO_0039013 GO:0015064 biolink:MolecularActivity obsolete UV-sensitive opsin OBSOLETE. An opsin with maximal absorption below 400 nm. go.json UV-sensitive opsin True http://purl.obolibrary.org/obo/GO_0015064 GO:0030679 biolink:CellularComponent cyanelle ribonuclease P complex A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. go.json cyanelle RNase P complex http://purl.obolibrary.org/obo/GO_0030679 GO:0030677 biolink:CellularComponent ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. go.json RNase P complex http://purl.obolibrary.org/obo/GO_0030677 goslim_pir GO:0030678 biolink:CellularComponent mitochondrial ribonuclease P complex A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans. go.json mitochondrial RNase P complex http://purl.obolibrary.org/obo/GO_0030678 GO:0030675 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030675 GO:0030676 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030676 GO:0039007 biolink:BiologicalProcess pronephric nephron morphogenesis The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros. go.json http://purl.obolibrary.org/obo/GO_0039007 GO:0039008 biolink:BiologicalProcess pronephric nephron tubule morphogenesis The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron. go.json http://purl.obolibrary.org/obo/GO_0039008 GO:0039005 biolink:BiologicalProcess specification of pronephric tubule identity The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0039005 GO:0039006 biolink:BiologicalProcess pronephric nephron tubule formation The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros. go.json pronephric tubule formation|pronephros tubule formation http://purl.obolibrary.org/obo/GO_0039006 GO:0015036 biolink:MolecularActivity disulfide oxidoreductase activity Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. Reactome:R-HSA-1222417|Reactome:R-HSA-1222644|Reactome:R-HSA-1222655|Reactome:R-HSA-1222690 go.json disulphide oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015036 GO:0015037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015037 GO:0039009 biolink:BiologicalProcess rectal diverticulum development The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior. go.json pronephric rectal diverticulum development http://purl.obolibrary.org/obo/GO_0039009 GO:0015038 biolink:MolecularActivity glutathione disulfide oxidoreductase activity Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. Reactome:R-HSA-111746 go.json glutaredoxin|glutathione disulphide oxidoreductase activity|glutathione oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015038 GO:0015039 biolink:MolecularActivity NADPH-adrenodoxin reductase activity Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. EC:1.18.1.6|MetaCyc:RXN-13685|RHEA:42312 go.json NADPH:adrenodoxin oxidoreductase activity|adrenodoxin reductase activity|adrenodoxin-type ferredoxin reductase activity http://purl.obolibrary.org/obo/GO_0015039 GO:0015032 biolink:BiologicalProcess obsolete storage protein import into fat body OBSOLETE. The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life. go.json fat body metabolic process|fat body metabolism|fat body storage protein uptake|import of storage protein into fat body|storage protein import by fat body cells|storage protein import into fat body cells|storage protein transport into fat body cells|storage protein uptake into fat body cells True http://purl.obolibrary.org/obo/GO_0015032 GO:0030673 biolink:CellularComponent axolemma The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. NIF_Subcellular:sao250772229|Wikipedia:Axolemma go.json axonal membrane http://purl.obolibrary.org/obo/GO_0030673 GO:0030674 biolink:MolecularActivity protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. go.json protein binding, bridging|protein recruiting activity|protein-protein adaptor http://purl.obolibrary.org/obo/GO_0030674 goslim_chembl|goslim_yeast GO:0015033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015033 GO:0015034 biolink:MolecularActivity obsolete cytochrome P450 activity OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer. go.json cytochrome P450 activity True http://purl.obolibrary.org/obo/GO_0015034 GO:0030671 biolink:CellularComponent clathrin-coated phagocytic vesicle membrane The lipid bilayer surrounding a clathrin-coated phagocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0030671 GO:0015035 biolink:MolecularActivity protein-disulfide reductase activity Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. MetaCyc:DISULFOXRED-RXN|Reactome:R-HSA-1307802|Reactome:R-HSA-264997|Reactome:R-HSA-3299753|Reactome:R-HSA-9817575 go.json haem lyase disulphide oxidoreductase activity|heme lyase disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|peptide disulphide oxidoreductase activity|protein disulfide oxidoreductase activity|protein disulfide-oxidoreductase activity|protein disulphide oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015035 GO:0030672 biolink:CellularComponent synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle. go.json http://purl.obolibrary.org/obo/GO_0030672 goslim_synapse GO:0039003 biolink:BiologicalProcess pronephric field specification The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop. go.json pronephric kidney field specification http://purl.obolibrary.org/obo/GO_0039003 GO:0030670 biolink:CellularComponent phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle. go.json phagosome membrane http://purl.obolibrary.org/obo/GO_0030670 GO:0039004 biolink:BiologicalProcess specification of pronephric proximal tubule identity The process in which the proximal tubule of the pronephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0039004 GO:0015030 biolink:CellularComponent Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. NIF_Subcellular:nlx_subcell_090901|Wikipedia:Cajal_body go.json Gemini of coiled bodies|Gems|coiled body http://purl.obolibrary.org/obo/GO_0015030 GO:0015031 biolink:BiologicalProcess protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json enzyme transport http://purl.obolibrary.org/obo/GO_0015031 goslim_chembl|goslim_pir|goslim_yeast GO:0030668 biolink:CellularComponent merozoite dense granule membrane The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites. go.json http://purl.obolibrary.org/obo/GO_0030668 GO:0030669 biolink:CellularComponent clathrin-coated endocytic vesicle membrane The lipid bilayer surrounding a clathrin-coated endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0030669 GO:0030666 biolink:CellularComponent endocytic vesicle membrane The lipid bilayer surrounding an endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0030666 GO:0030667 biolink:CellularComponent secretory granule membrane The lipid bilayer surrounding a secretory granule. go.json secretory vesicle membrane http://purl.obolibrary.org/obo/GO_0030667 GO:0030664 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030664 GO:0030665 biolink:CellularComponent clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle. go.json clathrin coated vesicle membrane http://purl.obolibrary.org/obo/GO_0030665 GO:0015047 biolink:MolecularActivity NADPH-cytochrome-c2 reductase activity Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2. EC:1.6.2.5|MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN|RHEA:15237 go.json NADPH:ferricytochrome-c2 oxidoreductase activity|cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)|reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate) http://purl.obolibrary.org/obo/GO_0015047 GO:0015048 biolink:MolecularActivity phthalate dioxygenase reductase activity Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems. go.json http://purl.obolibrary.org/obo/GO_0015048 GO:0015049 biolink:MolecularActivity methane monooxygenase activity Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O. EC:1.14.13.25|KEGG_REACTION:R01142|KEGG_REACTION:R01143|MetaCyc:METHANE-MONOOXYGENASE-RXN|UM-BBD_enzymeID:e0007 go.json methane hydroxylase activity|methane,NAD(P)H:oxygen oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0015049 GO:0030662 biolink:CellularComponent coated vesicle membrane The lipid bilayer surrounding a coated vesicle. go.json http://purl.obolibrary.org/obo/GO_0030662 GO:0015043 biolink:MolecularActivity leghemoglobin reductase activity Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin. EC:1.6.2.6|MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN go.json NAD(P)H:ferrileghemoglobin oxidoreductase activity|ferric leghemoglobin reductase activity http://purl.obolibrary.org/obo/GO_0015043 GO:0015044 biolink:MolecularActivity rubredoxin-NAD+ reductase activity Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+. EC:1.18.1.1|MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN|RHEA:18597 go.json DPNH-rubredoxin reductase activity|NADH--rubredoxin oxidoreductase activity|NADH--rubredoxin reductase activity|NADH:rubredoxin oxidoreductase activity|NADH:rubredoxin reductase activity|dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity|reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity|rubredoxin--NAD reductase activity|rubredoxin--nicotinamide adenine dinucleotide reductase activity|rubredoxin:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015044 GO:0030663 biolink:CellularComponent COPI-coated vesicle membrane The lipid bilayer surrounding a COPI-coated vesicle. go.json COPI coated vesicle membrane http://purl.obolibrary.org/obo/GO_0030663 GO:0015045 biolink:MolecularActivity rubredoxin-NAD(P)+ reductase activity Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+. EC:1.18.1.4|MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN go.json NAD(P)--rubredoxin oxidoreductase activity|NAD(P)H--rubredoxin oxidoreductase activity|NADPH:rubredoxin reductase activity|dinucleotide phosphate reductase activity|rubredoxin--nicotinamide adenine activity|rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity|rubredoxin:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015045 GO:0030660 biolink:CellularComponent Golgi-associated vesicle membrane The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. go.json Golgi vesicle membrane http://purl.obolibrary.org/obo/GO_0030660 GO:0015046 biolink:MolecularActivity rubredoxin-NADP+ reductase activity Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+. EC:1.18.1.4|RHEA:13949 go.json http://purl.obolibrary.org/obo/GO_0015046 GO:0030661 biolink:CellularComponent chitosome membrane The lipid bilayer surrounding a chitosome. go.json http://purl.obolibrary.org/obo/GO_0030661 GO:0015040 biolink:MolecularActivity obsolete electron transfer flavoprotein, group I OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway. go.json electron transfer flavoprotein, group I True http://purl.obolibrary.org/obo/GO_0015040 GO:0015041 biolink:MolecularActivity obsolete electron transfer flavoprotein, group II OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation. go.json electron transfer flavoprotein, group II True http://purl.obolibrary.org/obo/GO_0015041 GO:0015042 biolink:MolecularActivity trypanothione-disulfide reductase (NADP) activity Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide. EC:1.8.1.12|MetaCyc:1.8.1.12-RXN|RHEA:16757 go.json NADPH:trypanothione oxidoreductase activity|trypanothione reductase activity|trypanothione-disulfide reductase activity|trypanothione-disulphide reductase activity|trypanothione:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015042 GO:0040001 biolink:BiologicalProcess establishment of mitotic spindle localization The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. go.json establishment of mitotic spindle localisation|mitotic spindle positioning|mitotic spindle positioning and orientation|mitotic spindle positioning or orientation|spindle positioning during mitosis|spindle positioning involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_0040001 GO:0040002 biolink:BiologicalProcess collagen and cuticulin-based cuticle development Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans. go.json collagen and cuticulin-based cuticle anabolism|collagen and cuticulin-based cuticle biosynthetic process|collagen and cuticulin-based cuticle formation|collagen and cuticulin-based cuticle synthesis http://purl.obolibrary.org/obo/GO_0040002 GO:0040007 biolink:BiologicalProcess growth The increase in size or mass of an entire organism, a part of an organism or a cell. go.json growth pattern|non-developmental growth http://purl.obolibrary.org/obo/GO_0040007 gocheck_do_not_annotate|goslim_chembl|goslim_pir|goslim_plant GO:0040008 biolink:BiologicalProcess regulation of growth Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. go.json http://purl.obolibrary.org/obo/GO_0040008 GO:0040009 biolink:BiologicalProcess regulation of growth rate Any process that modulates the rate of growth of all or part of an organism. go.json http://purl.obolibrary.org/obo/GO_0040009 GO:0040003 biolink:BiologicalProcess chitin-based cuticle development Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster. go.json chitin-based cuticle anabolism|chitin-based cuticle biosynthetic process|chitin-based cuticle formation|chitin-based cuticle synthesis http://purl.obolibrary.org/obo/GO_0040003 GO:0040004 biolink:BiologicalProcess collagen and cuticulin-based cuticle attachment to epithelium Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans. go.json cuticular attachment to epithelium http://purl.obolibrary.org/obo/GO_0040004 GO:0040005 biolink:BiologicalProcess chitin-based cuticle attachment to epithelium Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster. go.json cuticular attachment to epithelium http://purl.obolibrary.org/obo/GO_0040005 GO:0040006 biolink:BiologicalProcess obsolete protein-based cuticle attachment to epithelium OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it. go.json cuticular attachment to epithelium|protein-based cuticle attachment to epithelium True http://purl.obolibrary.org/obo/GO_0040006 GO:0040010 biolink:BiologicalProcess positive regulation of growth rate Any process that increases the rate of growth of all or part of an organism. go.json activation of growth rate|stimulation of growth rate|up regulation of growth rate|up-regulation of growth rate|upregulation of growth rate http://purl.obolibrary.org/obo/GO_0040010 GO:0040011 biolink:BiologicalProcess locomotion Self-propelled movement of a cell or organism from one location to another. go.json http://purl.obolibrary.org/obo/GO_0040011 goslim_chembl|goslim_pir GO:0040012 biolink:BiologicalProcess regulation of locomotion Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. go.json http://purl.obolibrary.org/obo/GO_0040012 GO:0040013 biolink:BiologicalProcess negative regulation of locomotion Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. go.json down regulation of locomotion|down-regulation of locomotion|downregulation of locomotion|inhibition of locomotion http://purl.obolibrary.org/obo/GO_0040013 GO:0040018 biolink:BiologicalProcess positive regulation of multicellular organism growth Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. go.json positive regulation of body growth|positive regulation of body size http://purl.obolibrary.org/obo/GO_0040018 GO:0040019 biolink:BiologicalProcess positive regulation of embryonic development Any process that activates or increases the frequency, rate or extent of embryonic development. go.json activation of embryonic development|stimulation of embryonic development|up regulation of embryonic development|up-regulation of embryonic development|upregulation of embryonic development http://purl.obolibrary.org/obo/GO_0040019 GO:0040014 biolink:BiologicalProcess regulation of multicellular organism growth Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. go.json regulation of body growth|regulation of body size http://purl.obolibrary.org/obo/GO_0040014 GO:0040015 biolink:BiologicalProcess negative regulation of multicellular organism growth Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. go.json negative regulation of body growth|negative regulation of body size http://purl.obolibrary.org/obo/GO_0040015 GO:0040016 biolink:BiologicalProcess embryonic cleavage The first few specialized divisions of an activated animal egg. go.json http://purl.obolibrary.org/obo/GO_0040016 GO:0040017 biolink:BiologicalProcess positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. go.json activation of locomotion|stimulation of locomotion|up regulation of locomotion|up-regulation of locomotion|upregulation of locomotion http://purl.obolibrary.org/obo/GO_0040017 GO:0040021 biolink:BiologicalProcess hermaphrodite germ-line sex determination The determination of sex and sexual phenotype in the germ line of a hermaphrodite. go.json http://purl.obolibrary.org/obo/GO_0040021 GO:0040022 biolink:BiologicalProcess feminization of hermaphroditic germ-line The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite. go.json http://purl.obolibrary.org/obo/GO_0040022 GO:0040023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0040023 GO:0040024 biolink:BiologicalProcess dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. go.json http://purl.obolibrary.org/obo/GO_0040024 GO:0040020 biolink:BiologicalProcess regulation of meiotic nuclear division Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. go.json regulation of meiosis http://purl.obolibrary.org/obo/GO_0040020 GO:0040029 biolink:BiologicalProcess epigenetic regulation of gene expression A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. go.json regulation of gene expression, epigenetic http://purl.obolibrary.org/obo/GO_0040029 goslim_plant GO:0040025 biolink:BiologicalProcess vulval development The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. go.json http://purl.obolibrary.org/obo/GO_0040025 GO:0040026 biolink:BiologicalProcess positive regulation of vulval development Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. go.json activation of vulval development|stimulation of vulval development|up regulation of vulval development|up-regulation of vulval development|upregulation of vulval development http://purl.obolibrary.org/obo/GO_0040026 GO:0040027 biolink:BiologicalProcess negative regulation of vulval development Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. go.json down regulation of vulval development|down-regulation of vulval development|downregulation of vulval development|inhibition of vulval development http://purl.obolibrary.org/obo/GO_0040027 GO:0040028 biolink:BiologicalProcess regulation of vulval development Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. go.json http://purl.obolibrary.org/obo/GO_0040028 GO:0040032 biolink:BiologicalProcess post-embryonic body morphogenesis The process in which the anatomical structures of the post-embryonic soma are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0040032 GO:0040033 biolink:BiologicalProcess sRNA-mediated post-transcriptional gene silencing A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria. go.json RNA-mediated gene silencing by inhibition of translation|downregulation of mRNA translation, ncRNA-mediated|inhibition of mRNA translation, ncRNA-mediated|sRNA-mediated gene silencing|small RNA-mediated gene silencing http://purl.obolibrary.org/obo/GO_0040033 prokaryote_subset GO:0040034 biolink:BiologicalProcess regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. go.json developmental timing|heterochronic regulation of development|temporal regulation of development http://purl.obolibrary.org/obo/GO_0040034 GO:0040035 biolink:BiologicalProcess obsolete hermaphrodite genitalia development OBSOLETE. The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures. go.json True http://purl.obolibrary.org/obo/GO_0040035 GO:0040030 biolink:BiologicalProcess obsolete regulation of molecular function, epigenetic OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. go.json regulation of protein activity, epigenetic True http://purl.obolibrary.org/obo/GO_0040030 GO:0040031 biolink:BiologicalProcess snRNA modification The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA. go.json http://purl.obolibrary.org/obo/GO_0040031 GO:0040036 biolink:BiologicalProcess regulation of fibroblast growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. go.json regulation of FGF receptor signaling pathway|regulation of FGF receptor signalling pathway|regulation of FGFR signaling pathway http://purl.obolibrary.org/obo/GO_0040036 GO:0040037 biolink:BiologicalProcess negative regulation of fibroblast growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. go.json down regulation of fibroblast growth factor receptor signaling pathway|down-regulation of fibroblast growth factor receptor signaling pathway|downregulation of fibroblast growth factor receptor signaling pathway|inhibition of fibroblast growth factor receptor signaling pathway|negative regulation of FGF receptor signaling pathway|negative regulation of FGF receptor signalling pathway|negative regulation of FGFR signaling pathway http://purl.obolibrary.org/obo/GO_0040037 GO:0040038 biolink:BiologicalProcess polar body extrusion after meiotic divisions The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes. go.json http://purl.obolibrary.org/obo/GO_0040038 GO:0040039 biolink:BiologicalProcess inductive cell migration Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans. go.json http://purl.obolibrary.org/obo/GO_0040039 RO:0002630 biolink:OntologyClass directly negatively regulates RO:0002630 go.json http://purl.obolibrary.org/obo/RO_0002630 GO:0040040 biolink:BiologicalProcess thermosensory behavior Behavior that is dependent upon the sensation of temperature. go.json behavioral response to temperature stimulus|behavioural response to temperature stimulus|thermosensory behaviour http://purl.obolibrary.org/obo/GO_0040040 RO:0002629 biolink:OntologyClass directly positively regulates RO:0002629 go.json http://purl.obolibrary.org/obo/RO_0002629 GO:0005615 biolink:CellularComponent extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. NIF_Subcellular:sao1425028079 go.json intercellular space http://purl.obolibrary.org/obo/GO_0005615 goslim_chembl|goslim_drosophila|goslim_generic|prokaryote_subset GO:0005616 biolink:CellularComponent larval serum protein complex A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins. go.json http://purl.obolibrary.org/obo/GO_0005616 GO:0005613 biolink:CellularComponent obsolete laminin receptor protein OBSOLETE. (Was not defined before being made obsolete). go.json laminin receptor protein True http://purl.obolibrary.org/obo/GO_0005613 GO:0005614 biolink:CellularComponent interstitial matrix A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. go.json http://purl.obolibrary.org/obo/GO_0005614 GO:0005611 biolink:CellularComponent laminin-6 complex A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains. go.json laminin-311 complex|laminin-6A complex http://purl.obolibrary.org/obo/GO_0005611 GO:0005612 biolink:CellularComponent laminin-7 complex A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains. go.json laminin-321 complex|laminin-7A http://purl.obolibrary.org/obo/GO_0005612 GO:0005610 biolink:CellularComponent laminin-5 complex A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains. go.json laminin-332 complex|laminin-3A32 complex|laminin-5A complex http://purl.obolibrary.org/obo/GO_0005610 GO:0005619 biolink:CellularComponent ascospore wall The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi. go.json fungal-type spore wall http://purl.obolibrary.org/obo/GO_0005619 GO:0005617 biolink:CellularComponent obsolete larval serum protein-1 OBSOLETE. (Was not defined before being made obsolete). go.json LSP1|larval serum protein-1 True http://purl.obolibrary.org/obo/GO_0005617 GO:0005618 biolink:CellularComponent cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins. Wikipedia:Cell_wall go.json http://purl.obolibrary.org/obo/GO_0005618 gocheck_do_not_annotate|goslim_candida|goslim_chembl|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0005626 biolink:CellularComponent obsolete insoluble fraction OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water. go.json insoluble fraction|particle-bound True http://purl.obolibrary.org/obo/GO_0005626 GO:0005627 biolink:CellularComponent obsolete ascus OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number). go.json ascus True http://purl.obolibrary.org/obo/GO_0005627 GO:0005624 biolink:CellularComponent obsolete membrane fraction OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes. go.json membrane fraction True http://purl.obolibrary.org/obo/GO_0005624 GO:0005625 biolink:CellularComponent obsolete soluble fraction OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water. go.json soluble|soluble fraction True http://purl.obolibrary.org/obo/GO_0005625 GO:0005622 biolink:CellularComponent intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. Wikipedia:Intracellular go.json internal to cell|intracellular|nucleocytoplasm|protoplasm|protoplast http://purl.obolibrary.org/obo/GO_0005622 gocheck_do_not_annotate|goslim_chembl|goslim_metagenomics|goslim_plant GO:0005623 biolink:CellularComponent obsolete cell OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. NIF_Subcellular:sao1813327414|Wikipedia:Cell_(biology) go.json True http://purl.obolibrary.org/obo/GO_0005623 GO:0005620 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005620 GO:0005621 biolink:CellularComponent cellular bud scar Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age. go.json http://purl.obolibrary.org/obo/GO_0005621 GO:0005628 biolink:CellularComponent prospore membrane The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. go.json FSM|ascospore-type prospore membrane|forespore membrane http://purl.obolibrary.org/obo/GO_0005628 GO:0005604 biolink:CellularComponent basement membrane A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. Wikipedia:Basement_membrane go.json basal lamina|basement lamina|lamina densa http://purl.obolibrary.org/obo/GO_0005604 GO:0005605 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005605 GO:0005602 biolink:CellularComponent complement component C1 complex A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains. go.json complement component C1q complex http://purl.obolibrary.org/obo/GO_0005602 GO:0005603 biolink:CellularComponent obsolete complement component C2 complex OBSOLETE. (Was not defined before being made obsolete). go.json complement component C2 complex True http://purl.obolibrary.org/obo/GO_0005603 GO:0005600 biolink:CellularComponent collagen type XIII trimer A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0005600 GO:0005601 biolink:CellularComponent classical-complement-pathway C3/C5 convertase complex A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone. go.json http://purl.obolibrary.org/obo/GO_0005601 GO:0005608 biolink:CellularComponent laminin-3 complex A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains. go.json laminin-121 complex http://purl.obolibrary.org/obo/GO_0005608 GO:0005609 biolink:CellularComponent laminin-4 complex A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains. go.json laminin-221 complex http://purl.obolibrary.org/obo/GO_0005609 GO:0005606 biolink:CellularComponent laminin-1 complex A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains. go.json laminin-111 complex http://purl.obolibrary.org/obo/GO_0005606 GO:0005607 biolink:CellularComponent laminin-2 complex A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains. go.json laminin-211 complex http://purl.obolibrary.org/obo/GO_0005607 RO:0012001 biolink:OntologyClass has small molecule activator RO:0012001 go.json http://purl.obolibrary.org/obo/RO_0012001 RO:0012003 biolink:OntologyClass acts on population of RO:0012003 go.json http://purl.obolibrary.org/obo/RO_0012003 RO:0012008 biolink:OntologyClass results in fusion of RO:0012008 go.json http://purl.obolibrary.org/obo/RO_0012008 GO:0030659 biolink:CellularComponent cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle. go.json http://purl.obolibrary.org/obo/GO_0030659 GO:0030657 biolink:BiologicalProcess obsolete regulation of coenzyme and prosthetic group metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups. go.json regulation of coenzyme and prosthetic group metabolic process True http://purl.obolibrary.org/obo/GO_0030657 GO:0030658 biolink:CellularComponent transport vesicle membrane The lipid bilayer surrounding a transport vesicle. go.json constitutive secretory pathway transport vesicle membrane|secretory vesicle membrane http://purl.obolibrary.org/obo/GO_0030658 GO:0005699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005699 GO:0030655 biolink:BiologicalProcess beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. go.json beta-lactam antibiotic breakdown|beta-lactam antibiotic catabolism|beta-lactam antibiotic degradation http://purl.obolibrary.org/obo/GO_0030655 GO:0030656 biolink:BiologicalProcess regulation of vitamin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json regulation of vitamin metabolism http://purl.obolibrary.org/obo/GO_0030656 GO:0005697 biolink:CellularComponent telomerase holoenzyme complex Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. go.json http://purl.obolibrary.org/obo/GO_0005697 goslim_pir GO:0030653 biolink:BiologicalProcess beta-lactam antibiotic metabolic process The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. go.json beta-lactam antibiotic metabolism http://purl.obolibrary.org/obo/GO_0030653 GO:0005698 biolink:CellularComponent obsolete centromere OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid. go.json centromere True http://purl.obolibrary.org/obo/GO_0005698 GO:0030654 biolink:BiologicalProcess beta-lactam antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. go.json beta-lactam antibiotic anabolism|beta-lactam antibiotic biosynthesis|beta-lactam antibiotic formation|beta-lactam antibiotic synthesis http://purl.obolibrary.org/obo/GO_0030654 GO:0005695 biolink:CellularComponent obsolete chromatid OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis. go.json chromatid True http://purl.obolibrary.org/obo/GO_0005695 GO:0005696 biolink:CellularComponent obsolete telomere OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA. go.json telomere True http://purl.obolibrary.org/obo/GO_0005696 GO:0005693 biolink:CellularComponent U12 snRNP A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes. go.json snRNP U12 http://purl.obolibrary.org/obo/GO_0005693 GO:0005694 biolink:CellularComponent chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. Wikipedia:Chromosome go.json chromatid|interphase chromosome|prophase chromosome http://purl.obolibrary.org/obo/GO_0005694 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_metagenomics|goslim_pir|goslim_yeast|prokaryote_subset GO:0005691 biolink:CellularComponent U6atac snRNP A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes. go.json snRNP U6atac http://purl.obolibrary.org/obo/GO_0005691 GO:0005692 biolink:CellularComponent U11 snRNP A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes. go.json 12S U11 snRNP|snRNP U11 http://purl.obolibrary.org/obo/GO_0005692 GO:0005690 biolink:CellularComponent U4atac snRNP A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes. go.json snRNP U4atac http://purl.obolibrary.org/obo/GO_0005690 GO:0015018 biolink:MolecularActivity galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. EC:2.4.1.135|MetaCyc:2.4.1.135-RXN|RHEA:24168|Reactome:R-HSA-1889955|Reactome:R-HSA-3560802|Reactome:R-HSA-9638064 go.json UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity|UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity|glucuronosyltransferase I activity|uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0015018 GO:0015019 biolink:MolecularActivity heparan-alpha-glucosaminide N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. EC:2.3.1.78|MetaCyc:2.3.1.78-RXN|RHEA:15125|Reactome:R-HSA-1678660|Reactome:R-HSA-2090085|Reactome:R-HSA-2263492|Reactome:R-HSA-9036056 go.json acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity|acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity|heparin-alpha-glucosaminide N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0015019 GO:0015014 biolink:BiologicalProcess heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan. go.json heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism|heparan sulfate proteoglycan chain elongation|heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis|heparan sulfate proteoglycan formation, polysaccharide chain formation|heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis|heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis|heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process|heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process http://purl.obolibrary.org/obo/GO_0015014 GO:0015015 biolink:BiologicalProcess heparan sulfate proteoglycan biosynthetic process, enzymatic modification The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. go.json heparan sulfate proteoglycan anabolism, enzymatic modification|heparan sulfate proteoglycan formation, enzymatic modification|heparan sulfate proteoglycan synthesis, enzymatic modification|heparan sulphate proteoglycan biosynthesis, enzymatic modification|heparan sulphate proteoglycan biosynthetic process, enzymatic modification|heparin proteoglycan biosynthetic process, enzymatic modification http://purl.obolibrary.org/obo/GO_0015015 GO:0015016 biolink:MolecularActivity [heparan sulfate]-glucosamine N-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. EC:2.8.2.8|MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN|RHEA:21980|Reactome:R-HSA-2022860 go.json 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity|3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity|3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity|3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity|N-HSST activity|N-desulfoheparin sulfotransferase activity|N-heparan sulfate sulfotransferase activity|PAPS:DSH sulfotransferase activity|PAPS:N-desulfoheparin sulfotransferase activity|[heparan sulphate]-glucosamine N-sulphotransferase activity|desulfoheparin sulfotransferase activity|glucosaminyl N-deacetylase/N-sulfotransferase activity|heparan sulfate 2-N-sulfotransferase activity|heparan sulfate N-deacetylase/N-sulfotransferase activity|heparan sulfate N-sulfotransferase activity|heparin N-deacetylase/N-sulfotransferase activity|heparin N-deacetylase/N-sulphotransferase activity|heparin N-sulfotransferase activity|heparin-glucosamine N-sulfotransferase activity|heparitin N-sulfotransferase activity|heparitin N-sulphotransferase activity|heparitin sulfotransferase activity http://purl.obolibrary.org/obo/GO_0015016 GO:0015017 biolink:MolecularActivity obsolete glypican OBSOLETE. (Was not defined before being made obsolete). go.json glypican True http://purl.obolibrary.org/obo/GO_0015017 GO:0015010 biolink:BiologicalProcess tetrahydrocorphin metabolic process The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins. go.json tetrahydrocorphin metabolism http://purl.obolibrary.org/obo/GO_0015010 GO:0030651 biolink:BiologicalProcess peptide antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity. go.json peptide antibiotic anabolism|peptide antibiotic biosynthesis|peptide antibiotic formation|peptide antibiotic synthesis http://purl.obolibrary.org/obo/GO_0030651 GO:0030652 biolink:BiologicalProcess peptide antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity. go.json peptide antibiotic breakdown|peptide antibiotic catabolism|peptide antibiotic degradation http://purl.obolibrary.org/obo/GO_0030652 GO:0015011 biolink:BiologicalProcess nickel-tetrapyrrole coenzyme metabolic process The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase. go.json coenzyme F430 metabolic process|nickel-tetrapyrrole coenzyme metabolism http://purl.obolibrary.org/obo/GO_0015011 GO:0015012 biolink:BiologicalProcess heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. RESID:AA0210 go.json heparan sulfate proteoglycan anabolism|heparan sulfate proteoglycan biosynthesis|heparan sulfate proteoglycan formation|heparan sulfate proteoglycan synthesis|heparan sulphate proteoglycan biosynthesis|heparan sulphate proteoglycan biosynthetic process|heparin proteoglycan biosynthetic process http://purl.obolibrary.org/obo/GO_0015012 GO:0015013 biolink:BiologicalProcess heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan. go.json heparan sulfate proteoglycan anabolism, linkage to polypeptide|heparan sulfate proteoglycan formation, linkage to polypeptide|heparan sulfate proteoglycan synthesis, linkage to polypeptide|heparan sulphate proteoglycan biosynthesis, linkage to polypeptide|heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide|heparin proteoglycan biosynthetic process, linkage to polypeptide http://purl.obolibrary.org/obo/GO_0015013 gocheck_do_not_annotate GO:0030650 biolink:BiologicalProcess peptide antibiotic metabolic process The chemical reactions and pathways involving peptides with antibiotic activity. go.json peptide antibiotic metabolism http://purl.obolibrary.org/obo/GO_0030650 GO:0030648 biolink:BiologicalProcess aminoglycoside antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. go.json aminoglycoside antibiotic anabolism|aminoglycoside antibiotic biosynthesis|aminoglycoside antibiotic formation|aminoglycoside antibiotic synthesis http://purl.obolibrary.org/obo/GO_0030648 GO:0030649 biolink:BiologicalProcess aminoglycoside antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. go.json aminoglycoside antibiotic breakdown|aminoglycoside antibiotic catabolism|aminoglycoside antibiotic degradation http://purl.obolibrary.org/obo/GO_0030649 GO:0030646 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030646 GO:0030647 biolink:BiologicalProcess aminoglycoside antibiotic metabolic process The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. go.json aminoglycoside antibiotic metabolism http://purl.obolibrary.org/obo/GO_0030647 GO:0030644 biolink:BiologicalProcess intracellular chloride ion homeostasis A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell. go.json cellular chloride ion homeostasis http://purl.obolibrary.org/obo/GO_0030644 GO:0030645 biolink:BiologicalProcess glucose catabolic process to butyrate The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum. go.json butyrate fermentation|glucose fermentation to butyrate http://purl.obolibrary.org/obo/GO_0030645 GO:0030642 biolink:BiologicalProcess intracellular sulfate ion homeostasis A homeostatic process involved in the maintenance of a steady state level of sulfate ions within a cell. go.json cellular sulfate ion homeostasis|sulphate ion homeostasis http://purl.obolibrary.org/obo/GO_0030642 GO:0030643 biolink:BiologicalProcess intracellular phosphate ion homeostasis A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. go.json cellular phosphate ion homeostasis http://purl.obolibrary.org/obo/GO_0030643 goslim_pombe GO:0015029 biolink:MolecularActivity obsolete internalization receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json internalization receptor activity True http://purl.obolibrary.org/obo/GO_0015029 GO:0015025 biolink:MolecularActivity obsolete GPI-anchored membrane-bound receptor OBSOLETE. (Was not defined before being made obsolete). go.json GPI-anchored membrane-bound receptor True http://purl.obolibrary.org/obo/GO_0015025 GO:0015026 biolink:MolecularActivity coreceptor activity Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. go.json coreceptor, insoluble ligand activity|coreceptor, soluble ligand activity http://purl.obolibrary.org/obo/GO_0015026 GO:0015027 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015027 GO:0015028 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015028 GO:0015021 biolink:MolecularActivity heparin-sulfate lyase activity Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. EC:4.2.2.8|MetaCyc:4.2.2.8-RXN go.json [heparan sulfate]-sulfate lyase activity|heparin-sulfate eliminase activity|heparin-sulphate lyase activity|heparitin-sulfate lyase activity|heparitinase I|heparitinase II http://purl.obolibrary.org/obo/GO_0015021 GO:0030640 biolink:BiologicalProcess polyketide catabolic process The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. go.json polyketide breakdown|polyketide catabolism|polyketide degradation http://purl.obolibrary.org/obo/GO_0030640 GO:0030641 biolink:BiologicalProcess regulation of cellular pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. go.json cellular hydrogen ion homeostasis|proton homeostasis http://purl.obolibrary.org/obo/GO_0030641 GO:0015022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015022 GO:0015023 biolink:MolecularActivity obsolete syndecan OBSOLETE. (Was not defined before being made obsolete). go.json syndecan True http://purl.obolibrary.org/obo/GO_0015023 GO:0015024 biolink:MolecularActivity glucuronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. EC:3.1.6.18|MetaCyc:3.1.6.18-RXN go.json chondro-2-sulfatase activity|glucuronate-2-sulphatase activity|glucurono-2-sulfatase activity|polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0015024 GO:0015020 biolink:MolecularActivity glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. EC:2.4.1.17|MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN|RHEA:21032|Reactome:R-HSA-158546|Reactome:R-HSA-159179|Reactome:R-HSA-159194|Reactome:R-HSA-174916|Reactome:R-HSA-174931|Reactome:R-HSA-2162099|Reactome:R-HSA-5604954|Reactome:R-HSA-5604975|Reactome:R-HSA-5617143|Reactome:R-HSA-8941701|Reactome:R-HSA-9036102|Reactome:R-HSA-9036104|Reactome:R-HSA-9632038|Reactome:R-HSA-9632039|Reactome:R-HSA-9638097|Reactome:R-HSA-9749977|Reactome:R-HSA-9756134|Reactome:R-HSA-9756156|Reactome:R-HSA-9756183|Reactome:R-HSA-9758661 go.json 1-naphthol glucuronyltransferase activity|1-naphthol-UDP-glucuronosyltransferase activity|17-OH steroid UDPGT activity|17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|17beta-hydroxysteroid UDP-glucuronosyltransferase activity|3-OH androgenic UDPGT activity|3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|4-hydroxybiphenyl UDP-glucuronosyltransferase activity|4-methylumbelliferone UDP-glucuronosyltransferase activity|4-nitrophenol UDP-glucuronyltransferase activity|4-nitrophenol UDPGT activity|GT activity|PNP-UDPGT|UDP glucuronate-estradiol-glucuronosyltransferase activity|UDP glucuronate-estriol glucuronosyltransferase activity|UDP glucuronic acid transferase activity|UDP glucuronosyltransferase activity|UDP glucuronyltransferase activity|UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|UDP-glucuronate-bilirubin glucuronyltransferase activity|UDP-glucuronosyltransferase activity|UDP-glucuronyltransferase activity|UDPGA transferase activity|UDPGA-glucuronyltransferase activity|UDPGT activity|UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|bilirubin UDP-glucuronosyltransferase activity|bilirubin UDPGT activity|bilirubin glucuronyltransferase activity|bilirubin monoglucuronide glucuronyltransferase activity|bilirubin uridine diphosphoglucuronyltransferase activity|ciramadol UDP-glucuronyltransferase activity|estriol UDPglucuronosyltransferase activity|estrone UDPglucuronosyltransferase activity|morphine glucuronyltransferase activity|p-hydroxybiphenyl UDP glucuronyltransferase activity|p-nitrophenol UDP-glucuronosyltransferase activity|p-nitrophenol UDP-glucuronyltransferase activity|p-nitrophenylglucuronosyltransferase activity|p-phenylphenol glucuronyltransferase activity|phenyl-UDP-glucuronosyltransferase activity|pnp-UDPGT activity|uridine 5'-diphosphoglucuronyltransferase activity|uridine diphosphate glucuronyltransferase activity|uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|uridine diphosphoglucuronosyltransferase activity|uridine diphosphoglucuronyltransferase activity http://purl.obolibrary.org/obo/GO_0015020 GO:0030637 biolink:BiologicalProcess obsolete acetate derivative catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid. go.json acetate derivative breakdown|acetate derivative catabolic process|acetate derivative catabolism|acetate derivative degradation True http://purl.obolibrary.org/obo/GO_0030637 GO:0030638 biolink:BiologicalProcess polyketide metabolic process The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. go.json polyketide metabolism http://purl.obolibrary.org/obo/GO_0030638 GO:0030635 biolink:BiologicalProcess obsolete acetate derivative metabolic process OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid. go.json acetate derivative metabolic process|acetate derivative metabolism True http://purl.obolibrary.org/obo/GO_0030635 GO:0005679 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005679 GO:0030636 biolink:BiologicalProcess obsolete acetate derivative biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid. go.json acetate derivative anabolism|acetate derivative biosynthesis|acetate derivative biosynthetic process|acetate derivative formation|acetate derivative synthesis True http://purl.obolibrary.org/obo/GO_0030636 GO:0005677 biolink:CellularComponent chromatin silencing complex Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. go.json http://purl.obolibrary.org/obo/GO_0005677 GO:0030633 biolink:BiologicalProcess obsolete D-alanine family amino acid catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids. go.json D-alanine family amino acid breakdown|D-alanine family amino acid catabolism|D-alanine family amino acid degradation True http://purl.obolibrary.org/obo/GO_0030633 GO:0030634 biolink:BiologicalProcess carbon fixation by acetyl-CoA pathway A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2). MetaCyc:CODH-PWY|Wikipedia:Wood-Ljungdahl_pathway go.json Ljungdahl-Wood pathway|acetyl CoA pathway|reductive acetyl CoA pathway http://purl.obolibrary.org/obo/GO_0030634 GO:0005678 biolink:CellularComponent obsolete chromatin assembly complex OBSOLETE. Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure. go.json chromatin assembly complex|nucleosome assembly complex True http://purl.obolibrary.org/obo/GO_0005678 GO:0005675 biolink:CellularComponent transcription factor TFIIH holo complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. go.json holo TFIIH complex http://purl.obolibrary.org/obo/GO_0005675 GO:0030631 biolink:BiologicalProcess pyrrolysine incorporation The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases. RESID:AA0321 go.json lysine methylamine methyltransferase cofactor adduct incorporation|monomethylamine methyltransferase cofactor lysine adduct incorporation http://purl.obolibrary.org/obo/GO_0030631 GO:0030632 biolink:BiologicalProcess D-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid. go.json D-alanine anabolism|D-alanine biosynthesis|D-alanine formation|D-alanine synthesis http://purl.obolibrary.org/obo/GO_0030632 GO:0005676 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005676 GO:0005673 biolink:CellularComponent transcription factor TFIIE complex A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. go.json http://purl.obolibrary.org/obo/GO_0005673 GO:0005674 biolink:CellularComponent transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. go.json http://purl.obolibrary.org/obo/GO_0005674 GO:0005671 biolink:CellularComponent obsolete Ada2/Gcn5/Ada3 transcription activator complex OBSOLETE. A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. go.json ATAC complex True http://purl.obolibrary.org/obo/GO_0005671 GO:0005672 biolink:CellularComponent transcription factor TFIIA complex A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). go.json http://purl.obolibrary.org/obo/GO_0005672 GO:0005670 biolink:CellularComponent obsolete transcription-activating factor, 30kD OBSOLETE. (Was not defined before being made obsolete). go.json transcription-activating factor, 30kD True http://purl.obolibrary.org/obo/GO_0005670 GO:0030639 biolink:BiologicalProcess polyketide biosynthetic process The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. go.json polyketide anabolism|polyketide biosynthesis|polyketide formation|polyketide synthesis http://purl.obolibrary.org/obo/GO_0030639 GO:0030630 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030630 GO:0030626 biolink:MolecularActivity U12 snRNA binding Binding to a U12 small nuclear RNA (U12 snRNA). go.json http://purl.obolibrary.org/obo/GO_0030626 GO:0030627 biolink:MolecularActivity pre-mRNA 5'-splice site binding Binding to a pre-mRNA 5' splice site sequence. go.json pre-mRNA 5' splice site binding http://purl.obolibrary.org/obo/GO_0030627 GO:0030624 biolink:MolecularActivity U6atac snRNA binding Binding to a U6atac small nuclear RNA (U6atac snRNA). go.json http://purl.obolibrary.org/obo/GO_0030624 GO:0030625 biolink:MolecularActivity U11 snRNA binding Binding to a U11 small nuclear RNA (U11 snRNA). go.json http://purl.obolibrary.org/obo/GO_0030625 GO:0005688 biolink:CellularComponent U6 snRNP A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. go.json snRNP U6 http://purl.obolibrary.org/obo/GO_0005688 GO:0030622 biolink:MolecularActivity U4atac snRNA binding Binding to a U4atac small nuclear RNA (U4atac snRNA). go.json http://purl.obolibrary.org/obo/GO_0030622 GO:0005689 biolink:CellularComponent U12-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. Wikipedia:Minor_spliceosome go.json AT-AC spliceosomal complex|minor (U12-type) spliceosomal complex|minor spliceosomal complex http://purl.obolibrary.org/obo/GO_0005689 GO:0030623 biolink:MolecularActivity U5 snRNA binding Binding to a U5 small nuclear RNA (U5 snRNA). go.json http://purl.obolibrary.org/obo/GO_0030623 GO:0005686 biolink:CellularComponent U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. go.json 17S U2 snRNP|snRNP U2 http://purl.obolibrary.org/obo/GO_0005686 GO:0030620 biolink:MolecularActivity U2 snRNA binding Binding to a U2 small nuclear RNA (U2 snRNA). go.json http://purl.obolibrary.org/obo/GO_0030620 GO:0005687 biolink:CellularComponent U4 snRNP A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. go.json snRNP U4 http://purl.obolibrary.org/obo/GO_0005687 GO:0030621 biolink:MolecularActivity U4 snRNA binding Binding to a U4 small nuclear RNA (U4 snRNA). go.json http://purl.obolibrary.org/obo/GO_0030621 GO:0005684 biolink:CellularComponent U2-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. go.json GT-AG spliceosome|major (U2-type) spliceosomal complex|major spliceosomal complex http://purl.obolibrary.org/obo/GO_0005684 GO:0005685 biolink:CellularComponent U1 snRNP A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes. go.json snRNP U1 http://purl.obolibrary.org/obo/GO_0005685 GO:0005682 biolink:CellularComponent U5 snRNP A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes. go.json snRNP U5 http://purl.obolibrary.org/obo/GO_0005682 GO:0005683 biolink:CellularComponent U7 snRNP A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs. go.json snRNP U7 http://purl.obolibrary.org/obo/GO_0005683 GO:0005680 biolink:CellularComponent anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. Wikipedia:Anaphase-promoting_complex go.json APC|anaphase promoting complex|cyclosome http://purl.obolibrary.org/obo/GO_0005680 GO:0005681 biolink:CellularComponent spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. Wikipedia:Spliceosome go.json spliceosome|spliceosome complex http://purl.obolibrary.org/obo/GO_0005681 goslim_pir GO:0030628 biolink:MolecularActivity pre-mRNA 3'-splice site binding Binding to a pre-mRNA 3' splice site sequence. go.json pre-mRNA 3' splice site binding http://purl.obolibrary.org/obo/GO_0030628 GO:0030629 biolink:MolecularActivity U6 snRNA 3'-end binding Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end. go.json U6 snRNA 3' end binding http://purl.obolibrary.org/obo/GO_0030629 GO:0015007 biolink:MolecularActivity obsolete electron carrier, chlorophyll electron transport system OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system. go.json chlorophyll electron carrier|electron carrier, chlorophyll electron transport system True http://purl.obolibrary.org/obo/GO_0015007 GO:0015008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015008 GO:0015009 biolink:BiologicalProcess corrin metabolic process The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. go.json corrin metabolism http://purl.obolibrary.org/obo/GO_0015009 GO:0015003 biolink:MolecularActivity obsolete copper electron carrier OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system. go.json copper electron carrier True http://purl.obolibrary.org/obo/GO_0015003 GO:0015004 biolink:MolecularActivity obsolete small blue copper electron carrier OBSOLETE. (Was not defined before being made obsolete). go.json small blue copper electron carrier True http://purl.obolibrary.org/obo/GO_0015004 GO:0015005 biolink:MolecularActivity obsolete azurin OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin. go.json azurin True http://purl.obolibrary.org/obo/GO_0015005 GO:0015006 biolink:MolecularActivity obsolete plastocyanin OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I. go.json plastocyanin True http://purl.obolibrary.org/obo/GO_0015006 GO:0015000 biolink:MolecularActivity obsolete polyferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json polyferredoxin True http://purl.obolibrary.org/obo/GO_0015000 GO:0015001 biolink:MolecularActivity obsolete high-potential iron-sulfur carrier OBSOLETE. (Was not defined before being made obsolete). go.json HiPIP|high-potential iron-sulfur carrier|high-potential iron-sulphur carrier True http://purl.obolibrary.org/obo/GO_0015001 GO:0015002 biolink:MolecularActivity obsolete heme-copper terminal oxidase activity OBSOLETE. Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane. go.json haem-copper terminal oxidase activity True http://purl.obolibrary.org/obo/GO_0015002 GO:0030615 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030615 GO:0005659 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005659 GO:0030616 biolink:MolecularActivity obsolete transforming growth factor beta receptor, common-partner cytoplasmic mediator activity OBSOLETE. A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription. go.json TGF-beta receptor, common-partner cytoplasmic mediator activity|TGFbeta receptor, common-partner cytoplasmic mediator activity|co-SMAD protein|common mediator SMAD protein|common partner SMAD protein|common-mediator SMAD protein|common-partner SMAD protein True http://purl.obolibrary.org/obo/GO_0030616 GO:0030613 biolink:MolecularActivity oxidoreductase activity, acting on phosphorus or arsenic in donors Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.20.-.- go.json oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors http://purl.obolibrary.org/obo/GO_0030613 GO:0005657 biolink:CellularComponent replication fork The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. Wikipedia:Replication_fork go.json replication focus http://purl.obolibrary.org/obo/GO_0005657 GO:0030614 biolink:MolecularActivity oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. EC:1.20.4.- go.json oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor http://purl.obolibrary.org/obo/GO_0030614 GO:0005658 biolink:CellularComponent alpha DNA polymerase:primase complex A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. go.json DNA polymerase alpha:primase complex|heterotetrameric polymerase alpha holoenzyme|pol-prim|primosome http://purl.obolibrary.org/obo/GO_0005658 GO:0005655 biolink:CellularComponent nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. go.json nucleolar RNase P complex http://purl.obolibrary.org/obo/GO_0005655 GO:0030611 biolink:MolecularActivity arsenate reductase activity Catalysis of the interconversion of arsenate and arsenite. go.json http://purl.obolibrary.org/obo/GO_0030611 GO:0030612 biolink:MolecularActivity arsenate reductase (thioredoxin) activity Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin. MetaCyc:RXN-10737 go.json http://purl.obolibrary.org/obo/GO_0030612 GO:0005656 biolink:CellularComponent nuclear pre-replicative complex A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. go.json eukaryotic pre-replicative complex|pre-RC|pre-replicative complex http://purl.obolibrary.org/obo/GO_0005656 GO:0005653 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005653 GO:0005654 biolink:CellularComponent nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus. NIF_Subcellular:sao661522542|Wikipedia:Nucleoplasm go.json http://purl.obolibrary.org/obo/GO_0005654 goslim_chembl|goslim_generic|goslim_plant GO:0030610 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030610 GO:0005651 biolink:CellularComponent obsolete exportin OBSOLETE. (Was not defined before being made obsolete). go.json exportin True http://purl.obolibrary.org/obo/GO_0005651 GO:0005652 biolink:CellularComponent nuclear lamina The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. NIF_Subcellular:sao1455996588|Wikipedia:Nuclear_lamina go.json http://purl.obolibrary.org/obo/GO_0005652 GO:0005650 biolink:CellularComponent obsolete importin, alpha-subunit transport factor OBSOLETE. (Was not defined before being made obsolete). go.json CAS|importin, alpha-subunit transport factor True http://purl.obolibrary.org/obo/GO_0005650 GO:0030619 biolink:MolecularActivity U1 snRNA binding Binding to a U1 small nuclear RNA (U1 snRNA). go.json http://purl.obolibrary.org/obo/GO_0030619 GO:0030617 biolink:MolecularActivity obsolete transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity OBSOLETE. A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators. go.json TGF-beta receptor, inhibitory cytoplasmic mediator activity|TGFbeta receptor, inhibitory cytoplasmic mediator activity|inhibitory SMAD protein True http://purl.obolibrary.org/obo/GO_0030617 GO:0030618 biolink:MolecularActivity obsolete transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity OBSOLETE. A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription. go.json TGF-beta receptor, pathway-specific cytoplasmic mediator activity|TGFbeta receptor, pathway-specific cytoplasmic mediator activity|pathway restricted SMAD protein|pathway-restricted SMAD protein|pathway-specific SMAD protein|receptor regulated SMAD protein|receptor-regulated SMAD protein True http://purl.obolibrary.org/obo/GO_0030618 GO:0030604 biolink:MolecularActivity 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH. EC:1.1.1.267|KEGG_REACTION:R05688|MetaCyc:DXPREDISOM-RXN|RHEA:13717 go.json 1-deoxy-D-xylulose-5-phosphate isomeroreductase activity|1-deoxyxylulose-5-phosphate reductoisomerase activity|2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)|2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity|DOXP reductoisomerase activity|DXP-reductoisomerase activity http://purl.obolibrary.org/obo/GO_0030604 GO:0030605 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030605 GO:0030602 biolink:MolecularActivity obsolete chymosin activity OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein. go.json chymosin activity|rennin|rennin (but this should be avoided since it leads to confusion with renin) True http://purl.obolibrary.org/obo/GO_0030602 GO:0005668 biolink:CellularComponent RNA polymerase transcription factor SL1 complex A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48. go.json TIF-IB|selectivity factor SL1 complex http://purl.obolibrary.org/obo/GO_0005668 GO:0005669 biolink:CellularComponent transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. go.json http://purl.obolibrary.org/obo/GO_0005669 GO:0030603 biolink:MolecularActivity oxaloacetase activity Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate. EC:3.7.1.1|KEGG_REACTION:R00338|MetaCyc:OXALOACETASE-RXN|RHEA:24432 go.json oxalacetic hydrolase activity|oxaloacetate acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0030603 GO:0030600 biolink:MolecularActivity feruloyl esterase activity Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide. EC:3.1.1.73|MetaCyc:3.1.1.73-RXN go.json 4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity|FAE-I|FAE-II|FAE-III|FAEA|cinnAE|cinnamoyl ester hydrolase activity|ferulic acid esterase activity|hemicellulase accessory|hydroxycinnamoyl esterase activity http://purl.obolibrary.org/obo/GO_0030600 GO:0005666 biolink:CellularComponent RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. go.json DNA-directed RNA polymerase III activity|DNA-directed RNA polymerase III complex http://purl.obolibrary.org/obo/GO_0005666 GO:0005667 biolink:CellularComponent transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. go.json cytoplasmic transcription factor complex|nuclear transcription factor complex|transcription factor complex http://purl.obolibrary.org/obo/GO_0005667 goslim_pir GO:0030601 biolink:MolecularActivity obsolete aminopeptidase B activity OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys. go.json Cl--activated arginine aminopeptidase activity|L-arginine aminopeptidase activity|aminopeptidase B activity|arginyl aminopeptidase activity|arylamidase II|cytosol aminopeptidase IV True http://purl.obolibrary.org/obo/GO_0030601 GO:0005664 biolink:CellularComponent nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. go.json eukaryotic ORC|nuclear ORC http://purl.obolibrary.org/obo/GO_0005664 GO:0005665 biolink:CellularComponent RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. go.json DNA-directed RNA polymerase II, core complex|RNA polymerase II complex|RNAP II complex http://purl.obolibrary.org/obo/GO_0005665 GO:0005662 biolink:CellularComponent DNA replication factor A complex A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. Wikipedia:Replication_protein_A go.json RPA|replication protein A http://purl.obolibrary.org/obo/GO_0005662 GO:0005663 biolink:CellularComponent DNA replication factor C complex A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. go.json RFC complex|activator 1 complex http://purl.obolibrary.org/obo/GO_0005663 goslim_pir GO:0005660 biolink:CellularComponent obsolete delta-DNA polymerase cofactor complex OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP. go.json delta DNA polymerase cofactor complex|delta-DNA polymerase cofactor complex True http://purl.obolibrary.org/obo/GO_0005660 GO:0005661 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005661 GO:0030608 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030608 GO:0030609 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030609 GO:0030606 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030606 GO:0030607 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030607 GO:0005637 biolink:CellularComponent nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. NIF_Subcellular:sao1612527463 go.json inner envelope|inner nuclear membrane|nucleus inner membrane http://purl.obolibrary.org/obo/GO_0005637 GO:0005638 biolink:CellularComponent lamin filament Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C. go.json type V intermediate filament http://purl.obolibrary.org/obo/GO_0005638 GO:0005635 biolink:CellularComponent nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). Wikipedia:Nuclear_envelope go.json http://purl.obolibrary.org/obo/GO_0005635 goslim_chembl|goslim_generic|goslim_plant GO:0005636 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005636 GO:0005633 biolink:CellularComponent ascus lipid droplet Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins. go.json ascus lipid particle http://purl.obolibrary.org/obo/GO_0005633 GO:0005634 biolink:CellularComponent nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. NIF_Subcellular:sao1702920020|Wikipedia:Cell_nucleus go.json cell nucleus|horsetail nucleus http://purl.obolibrary.org/obo/GO_0005634 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast GO:0005631 biolink:CellularComponent chitosan layer of spore wall The second outermost layer of the spore wall, as described in Saccharomyces. go.json http://purl.obolibrary.org/obo/GO_0005631 GO:0005632 biolink:CellularComponent inner layer of spore wall Either of the two innermost layers of the spore wall, as described in Saccharomyces. go.json http://purl.obolibrary.org/obo/GO_0005632 GO:0005630 biolink:CellularComponent dityrosine layer of spore wall The outermost layer of the spore wall, as described in Saccharomyces. go.json http://purl.obolibrary.org/obo/GO_0005630 GO:0005639 biolink:CellularComponent obsolete integral component of nuclear inner membrane OBSOLETE. The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to nuclear inner membrane True http://purl.obolibrary.org/obo/GO_0005639 GO:0005648 biolink:CellularComponent obsolete importin, beta-subunit OBSOLETE. (Was not defined before being made obsolete). go.json importin, beta-subunit|karyopherin-beta1 True http://purl.obolibrary.org/obo/GO_0005648 GO:0005649 biolink:CellularComponent obsolete transportin OBSOLETE. (Was not defined before being made obsolete). go.json karyopherin-beta2|transportin True http://purl.obolibrary.org/obo/GO_0005649 GO:0005646 biolink:CellularComponent obsolete importin OBSOLETE. (Was not defined before being made obsolete). go.json importin|karyopherin True http://purl.obolibrary.org/obo/GO_0005646 GO:0005647 biolink:CellularComponent obsolete importin, alpha-subunit OBSOLETE. (Was not defined before being made obsolete). go.json importin, alpha-subunit|karyopherin-alpha True http://purl.obolibrary.org/obo/GO_0005647 GO:0005644 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005644 GO:0005645 biolink:CellularComponent obsolete RAN-binding protein OBSOLETE. (Was not defined before being made obsolete). go.json RAN-binding protein True http://purl.obolibrary.org/obo/GO_0005645 GO:0005642 biolink:CellularComponent annulate lamellae Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER. go.json http://purl.obolibrary.org/obo/GO_0005642 GO:0005643 biolink:CellularComponent nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. NIF_Subcellular:sao220861693|Wikipedia:Nuclear_pore go.json NPC|nuclear pore complex|nuclear pore membrane protein|nucleopore http://purl.obolibrary.org/obo/GO_0005643 goslim_pir GO:0005640 biolink:CellularComponent nuclear outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. NIF_Subcellular:sao1617136075 go.json nucleus outer envelope|perinuclear membrane http://purl.obolibrary.org/obo/GO_0005640 GO:0005641 biolink:CellularComponent nuclear envelope lumen The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. go.json nuclear intermembrane space|nuclear membrane lumen|perinuclear space http://purl.obolibrary.org/obo/GO_0005641 GO:0015197 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015197 GO:0015198 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015198 GO:0015199 biolink:MolecularActivity amino-acid betaine transmembrane transporter activity Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid. go.json betaine transmembrane transporter activity|betaine/GABA:sodium symporter activity|glycine betaine/proline porter activity|proline/glycine/betaine:hydrogen/sodium symporter activity http://purl.obolibrary.org/obo/GO_0015199 GO:0015193 biolink:MolecularActivity L-proline transmembrane transporter activity Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. Reactome:R-HSA-8870354 go.json L-proline permease activity|L-proline transporter activity|glycine betaine/proline porter activity|proline/glycine/betaine:hydrogen/sodium symporter activity http://purl.obolibrary.org/obo/GO_0015193 GO:0015194 biolink:MolecularActivity L-serine transmembrane transporter activity Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. Reactome:R-HSA-8932980 go.json L-serine permease activity|L-serine transporter activity|serine transporter activity|threonine/serine:sodium symporter activity http://purl.obolibrary.org/obo/GO_0015194 GO:0015195 biolink:MolecularActivity L-threonine transmembrane transporter activity Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. go.json L-threonine permease activity|L-threonine transporter activity|threonine/serine:sodium symporter activity http://purl.obolibrary.org/obo/GO_0015195 GO:0015196 biolink:MolecularActivity L-tryptophan transmembrane transporter activity Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. Reactome:R-HSA-8870352 go.json L-tryptophan permease activity|L-tryptophan transporter activity|valine/tyrosine/tryptophan permease activity http://purl.obolibrary.org/obo/GO_0015196 GO:0015180 biolink:MolecularActivity L-alanine transmembrane transporter activity Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. go.json L-alanine transporter activity http://purl.obolibrary.org/obo/GO_0015180 GO:0015181 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015181 GO:0015179 biolink:MolecularActivity L-amino acid transmembrane transporter activity Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. Reactome:R-HSA-212614 go.json L-amino acid transporter activity http://purl.obolibrary.org/obo/GO_0015179 GO:0015175 biolink:MolecularActivity neutral L-amino acid transmembrane transporter activity Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. go.json neutral amino acid transmembrane transporter activity|neutral amino acid transporter activity http://purl.obolibrary.org/obo/GO_0015175 GO:0015176 biolink:MolecularActivity obsolete holin OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases. go.json holin True http://purl.obolibrary.org/obo/GO_0015176 GO:0015177 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015177 GO:0015178 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015178 GO:0015171 biolink:MolecularActivity amino acid transmembrane transporter activity Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. Reactome:R-HSA-210439|Reactome:R-HSA-212642|Reactome:R-HSA-351963|Reactome:R-HSA-351987|Reactome:R-HSA-352029|Reactome:R-HSA-352052|Reactome:R-HSA-352059|Reactome:R-HSA-352103|Reactome:R-HSA-352107|Reactome:R-HSA-352108|Reactome:R-HSA-352119|Reactome:R-HSA-352136|Reactome:R-HSA-352158|Reactome:R-HSA-352174|Reactome:R-HSA-352182|Reactome:R-HSA-352191|Reactome:R-HSA-352232|Reactome:R-HSA-352347|Reactome:R-HSA-352354|Reactome:R-HSA-352364|Reactome:R-HSA-352371|Reactome:R-HSA-352379|Reactome:R-HSA-352385|Reactome:R-HSA-375405|Reactome:R-HSA-375417|Reactome:R-HSA-375473|Reactome:R-HSA-375487|Reactome:R-HSA-375768|Reactome:R-HSA-375770|Reactome:R-HSA-375776|Reactome:R-HSA-375790|Reactome:R-HSA-376200|Reactome:R-HSA-378513|Reactome:R-HSA-379415|Reactome:R-HSA-379426|Reactome:R-HSA-379432|Reactome:R-HSA-5653850|Reactome:R-HSA-5655702|Reactome:R-HSA-5659674|Reactome:R-HSA-5659734|Reactome:R-HSA-5659755|Reactome:R-HSA-5660694|Reactome:R-HSA-5660890|Reactome:R-HSA-5660910|Reactome:R-HSA-888592|Reactome:R-HSA-8952726 go.json amino acid permease activity|amino acid transporter activity|amino acid/choline transmembrane transporter activity|general amino acid permease activity|hydroxy/aromatic amino acid permease activity http://purl.obolibrary.org/obo/GO_0015171 GO:0015172 biolink:MolecularActivity acidic amino acid transmembrane transporter activity Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3. Reactome:R-HSA-372448 go.json acidic amino acid transporter activity http://purl.obolibrary.org/obo/GO_0015172 GO:0015173 biolink:MolecularActivity aromatic amino acid transmembrane transporter activity Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. go.json aromatic amino acid transporter activity|hydroxy/aromatic amino acid permease activity|valine/tyrosine/tryptophan permease activity http://purl.obolibrary.org/obo/GO_0015173 GO:0015174 biolink:MolecularActivity basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. Reactome:R-HSA-8932851|Reactome:R-HSA-8959781 go.json basic amino acid permease activity|basic amino acid transporter activity|cationic amino acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015174 GO:0015190 biolink:MolecularActivity L-leucine transmembrane transporter activity Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. go.json L-leucine transporter activity|leucine/isoleucine/valine porter activity|leucine/valine/isoleucine permease activity http://purl.obolibrary.org/obo/GO_0015190 GO:0015191 biolink:MolecularActivity L-methionine transmembrane transporter activity Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid. go.json L-methionine transporter activity http://purl.obolibrary.org/obo/GO_0015191 GO:0015192 biolink:MolecularActivity L-phenylalanine transmembrane transporter activity Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid. go.json L-phenylalanine permease activity|L-phenylalanine transporter activity http://purl.obolibrary.org/obo/GO_0015192 GO:0015186 biolink:MolecularActivity L-glutamine transmembrane transporter activity Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. go.json asparagine/glutamine permease activity http://purl.obolibrary.org/obo/GO_0015186 GO:0015187 biolink:MolecularActivity glycine transmembrane transporter activity Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. go.json glycine betaine/proline porter activity|glycine transporter activity|proline/glycine/betaine:hydrogen/sodium symporter activity http://purl.obolibrary.org/obo/GO_0015187 GO:0015188 biolink:MolecularActivity L-isoleucine transmembrane transporter activity Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. go.json L-isoleucine transporter activity|isoleucine/valine:sodium symporter activity|leucine/isoleucine/valine porter activity|leucine/valine/isoleucine permease activity http://purl.obolibrary.org/obo/GO_0015188 GO:0015189 biolink:MolecularActivity L-lysine transmembrane transporter activity Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. go.json L-lysine permease|histidine/arginine/lysine/ornithine porter activity|lysine permease activity http://purl.obolibrary.org/obo/GO_0015189 GO:0015182 biolink:MolecularActivity L-asparagine transmembrane transporter activity Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid. go.json L-asparagine transporter activity|asparagine/glutamine permease activity http://purl.obolibrary.org/obo/GO_0015182 GO:0015183 biolink:MolecularActivity L-aspartate transmembrane transporter activity Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. go.json L-aspartate transporter activity|glutamate/aspartate porter activity|glutamate/aspartate:sodium symporter activity http://purl.obolibrary.org/obo/GO_0015183 GO:0015184 biolink:MolecularActivity L-cystine transmembrane transporter activity Enables the transfer of L-cystine from one side of a membrane to the other. Reactome:R-HSA-5340130 go.json L-cystine transporter activity|cystine/diaminopimelate porter activity http://purl.obolibrary.org/obo/GO_0015184 GO:0015185 biolink:MolecularActivity gamma-aminobutyric acid transmembrane transporter activity Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). go.json 4-aminobutanoate transporter activity|4-aminobutyrate transporter activity|GABA transporter activity|betaine/GABA:sodium symporter activity http://purl.obolibrary.org/obo/GO_0015185 GO:0030798 biolink:MolecularActivity trans-aconitate 2-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine. EC:2.1.1.144|KEGG_REACTION:R05763|MetaCyc:RXN0-2441|RHEA:14969 go.json S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030798 GO:0030799 biolink:BiologicalProcess obsolete regulation of cyclic nucleotide metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. go.json regulation of cyclic nucleotide metabolism True http://purl.obolibrary.org/obo/GO_0030799 GO:0030796 biolink:MolecularActivity cycloartenol 24-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H+. EC:2.1.1.142|KEGG_REACTION:R05760|MetaCyc:2.1.1.142-RXN|RHEA:13137 go.json S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity|sterol C-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030796 GO:0030797 biolink:MolecularActivity 24-methylenesterol C-methyltransferase activity Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H+. EC:2.1.1.143|KEGG_REACTION:R05776|MetaCyc:2.1.1.143-RXN|RHEA:21044 go.json 24-methylenelophenol C-24(1)-methyltransferase activity|24-methylenelophenol C-241-methyltransferase activity|S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity|SMT(2) activity|SMT2 http://purl.obolibrary.org/obo/GO_0030797 GO:0015157 biolink:MolecularActivity oligosaccharide transmembrane transporter activity Enables the transfer of oligosaccharide from one side of a membrane to the other. go.json endosomal oligosaccharide transporter http://purl.obolibrary.org/obo/GO_0015157 GO:0015158 biolink:MolecularActivity raffinose transmembrane transporter activity Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. go.json raffinose permease http://purl.obolibrary.org/obo/GO_0015158 GO:0015159 biolink:MolecularActivity polysaccharide transmembrane transporter activity Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json http://purl.obolibrary.org/obo/GO_0015159 GO:0015153 biolink:MolecularActivity rhamnose transmembrane transporter activity Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. RHEA:34995 go.json ATP-dependent rhamnose transmembrane transporter activity|ATPase-coupled rhamnose transmembrane transporter activity|rhamnose-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015153 GO:0030794 biolink:MolecularActivity (S)-coclaurine-N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine. EC:2.1.1.140|MetaCyc:2.1.1.140-RXN|RHEA:17409 go.json S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030794 GO:0030795 biolink:MolecularActivity methyl jasmonate methylesterase activity Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate. EC:2.1.1.141|MetaCyc:RXN-10768|RHEA:13349 go.json S-adenosyl-L-methionine:jasmonate O-methyltransferase activity|S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity|jasmonic acid carboxyl methyltransferase activity http://purl.obolibrary.org/obo/GO_0030795 GO:0015154 biolink:MolecularActivity disaccharide transmembrane transporter activity Enables the transfer of disaccharide from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015154 GO:0030792 biolink:MolecularActivity methylarsonite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate. MetaCyc:2.1.1.138-RXN go.json http://purl.obolibrary.org/obo/GO_0030792 GO:0015155 biolink:MolecularActivity lactose transmembrane transporter activity Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. go.json lactose permease activity|lactose/glucose efflux transporter activity http://purl.obolibrary.org/obo/GO_0015155 GO:0030793 biolink:MolecularActivity 3'-demethylstaurosporine O-methyltransferase activity Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H+ + staurosporine. EC:2.1.1.139|KEGG_REACTION:R05757|MetaCyc:2.1.1.139-RXN|RHEA:11696 go.json 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity|S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity|staurosporine synthase activity http://purl.obolibrary.org/obo/GO_0030793 GO:0015156 biolink:MolecularActivity melibiose transmembrane transporter activity Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants. go.json http://purl.obolibrary.org/obo/GO_0015156 GO:0030790 biolink:MolecularActivity chlorophenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole. EC:2.1.1.136|MetaCyc:2.1.1.136-RXN|RHEA:18909 go.json S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity|halogenated phenol O-methyltransferase activity|trichlorophenol O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030790 GO:0030791 biolink:MolecularActivity arsenite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. EC:2.1.1.137|MetaCyc:2.1.1.137-RXN|Reactome:R-HSA-5696213|Reactome:R-HSA-5696220|UM-BBD_reactionID:r0805 go.json S-adenosyl-L-methionine:arsenic(III) methyltransferase activity|S-adenosyl-L-methionine:arsenite As-methyltransferase activity|S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030791 GO:0015150 biolink:MolecularActivity fucose transmembrane transporter activity Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. go.json http://purl.obolibrary.org/obo/GO_0015150 GO:0015151 biolink:MolecularActivity alpha-glucoside transmembrane transporter activity Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. go.json http://purl.obolibrary.org/obo/GO_0015151 GO:0015152 biolink:MolecularActivity glucose-6-phosphate transmembrane transporter activity Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. go.json http://purl.obolibrary.org/obo/GO_0015152 GO:0030789 biolink:MolecularActivity precorrin-3B C17-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4. EC:2.1.1.131|MetaCyc:2.1.1.131-RXN|RHEA:12761 go.json CobJ|S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity|precorrin-3 methylase activity|precorrin-3 methyltransferase activity http://purl.obolibrary.org/obo/GO_0030789 GO:0015170 biolink:MolecularActivity propanediol transmembrane transporter activity Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. go.json http://purl.obolibrary.org/obo/GO_0015170 GO:0030787 biolink:MolecularActivity inositol 4-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+. EC:2.1.1.129|KEGG_REACTION:R01190|MetaCyc:2.1.1.129-RXN|RHEA:23248 go.json S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity|myo-inositol 4-O-methyltransferase activity|myo-inositol 6-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030787 GO:0030788 biolink:MolecularActivity precorrin-2 C20-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A. EC:2.1.1.130|KEGG_REACTION:R03948|MetaCyc:2.1.1.130-RXN|RHEA:16841 go.json S-adenosyl-L-methionine--precorrin-2 methyltransferase activity|S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030788 GO:0030785 biolink:MolecularActivity [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine. EC:2.1.1.127|MetaCyc:2.1.1.127-RXN|RHEA:50996 go.json RuBisCO LSMT activity|RuBisCO methyltransferase activity|S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity|S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity|ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity|ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity|ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030785 GO:0030786 biolink:MolecularActivity (RS)-norcoclaurine 6-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine. EC:2.1.1.128|MetaCyc:2.1.1.128-RXN|RHEA:19941 go.json S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030786 GO:0015168 biolink:MolecularActivity glycerol transmembrane transporter activity Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. go.json http://purl.obolibrary.org/obo/GO_0015168 GO:0015169 biolink:MolecularActivity glycerol-3-phosphate transmembrane transporter activity Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. go.json http://purl.obolibrary.org/obo/GO_0015169 GO:0015164 biolink:MolecularActivity glucuronoside transmembrane transporter activity Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. go.json glucuronide transporter activity http://purl.obolibrary.org/obo/GO_0015164 GO:0030783 biolink:MolecularActivity [cytochrome c]-methionine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine. EC:2.1.1.123|MetaCyc:2.1.1.123-RXN go.json S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity|cytochrome c-methionine S-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030783 GO:0030784 biolink:MolecularActivity 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline. EC:2.1.1.116|MetaCyc:2.1.1.116-RXN|RHEA:17789 go.json S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030784 GO:0015165 biolink:MolecularActivity pyrimidine nucleotide-sugar transmembrane transporter activity Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json http://purl.obolibrary.org/obo/GO_0015165 GO:0015166 biolink:MolecularActivity polyol transmembrane transporter activity Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol. Reactome:R-HSA-429571 go.json sugar/polyol channel activity http://purl.obolibrary.org/obo/GO_0015166 GO:0030781 biolink:MolecularActivity 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline. EC:2.1.1.121|MetaCyc:2.1.1.121-RXN|RHEA:11892 go.json S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030781 GO:0015167 biolink:MolecularActivity arabitol transmembrane transporter activity Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. go.json arabinitol transporter activity http://purl.obolibrary.org/obo/GO_0015167 GO:0030782 biolink:MolecularActivity (S)-tetrahydroprotoberberine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine. EC:2.1.1.122|MetaCyc:2.1.1.122-RXN|RHEA:12805 go.json S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity|tetrahydroprotoberberine cis-N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030782 GO:0015160 biolink:MolecularActivity beta-glucan transmembrane transporter activity Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. go.json http://purl.obolibrary.org/obo/GO_0015160 GO:0015161 biolink:MolecularActivity lipid III floppase activity Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. TC:2.A.66.2.12|TC:2.A.66.2.3 go.json capsular polysaccharide transmembrane transporter activity|capsule polysaccharide transporter activity|undecaprenol-pyrophosphate O-antigen flippase activity http://purl.obolibrary.org/obo/GO_0015161 GO:0030780 biolink:MolecularActivity 12-hydroxydihydrochelirubine 12-O-methyltransferase activity Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H+. EC:2.1.1.120|KEGG_REACTION:R04705|MetaCyc:2.1.1.120-RXN|RHEA:21092 go.json S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030780 GO:0015162 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015162 GO:0015163 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015163 GO:0005736 biolink:CellularComponent RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. go.json DNA-directed RNA polymerase I activity|DNA-directed RNA polymerase I complex http://purl.obolibrary.org/obo/GO_0005736 GO:0005737 biolink:CellularComponent cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. Wikipedia:Cytoplasm go.json http://purl.obolibrary.org/obo/GO_0005737 goslim_candida|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0005734 biolink:CellularComponent obsolete box C + D snoRNP protein OBSOLETE. (Was not defined before being made obsolete). go.json box C + D snoRNP protein True http://purl.obolibrary.org/obo/GO_0005734 GO:0005735 biolink:CellularComponent obsolete box H + ACA snoRNP protein OBSOLETE. (Was not defined before being made obsolete). go.json box H + ACA snoRNP protein True http://purl.obolibrary.org/obo/GO_0005735 GO:0005732 biolink:CellularComponent sno(s)RNA-containing ribonucleoprotein complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA. go.json sRNP|small nucleolar ribonucleoprotein|small nucleolar ribonucleoprotein complex|small ribonucleoprotein|small ribonucleoprotein protein complex|snoRNP http://purl.obolibrary.org/obo/GO_0005732 goslim_pir GO:0005733 biolink:CellularComponent obsolete small nucleolar RNA OBSOLETE. (Was not defined before being made obsolete). go.json small nucleolar RNA|snoRNA True http://purl.obolibrary.org/obo/GO_0005733 GO:0005730 biolink:CellularComponent nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. NIF_Subcellular:sao1820400233|Wikipedia:Nucleolus go.json http://purl.obolibrary.org/obo/GO_0005730 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_plant|goslim_yeast GO:0005731 biolink:CellularComponent nucleolus organizer region A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed. Wikipedia:Nucleolus_organizer_region go.json NOR|nucleolus organiser region|nucleolus organizer complex http://purl.obolibrary.org/obo/GO_0005731 GO:0005739 biolink:CellularComponent mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. NIF_Subcellular:sao1860313010|Wikipedia:Mitochondrion go.json mitochondria http://purl.obolibrary.org/obo/GO_0005739 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast GO:0005747 biolink:CellularComponent mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. go.json http://purl.obolibrary.org/obo/GO_0005747 GO:0005748 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005748 GO:0005745 biolink:CellularComponent m-AAA complex Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria. go.json http://purl.obolibrary.org/obo/GO_0005745 GO:0005746 biolink:CellularComponent mitochondrial respirasome The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. go.json mitochondrial electron transport chain|mitochondrial respiratory chain|mitochondrial respiratory chain supercomplex|mitochondrial respiratory supercomplex http://purl.obolibrary.org/obo/GO_0005746 GO:0005743 biolink:CellularComponent mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. NIF_Subcellular:sao1371347282|Wikipedia:Inner_mitochondrial_membrane go.json inner mitochondrial membrane|inner mitochondrion membrane|mitochondrion inner membrane http://purl.obolibrary.org/obo/GO_0005743 GO:0005744 biolink:CellularComponent TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. go.json Tim23 complex|mitochondrial inner membrane pre-sequence translocase complex|mitochondrial inner membrane presequence translocase complex|mitochondrial inner membrane translocase complex http://purl.obolibrary.org/obo/GO_0005744 goslim_pir GO:0005741 biolink:CellularComponent mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. NIF_Subcellular:sao1289741256|Wikipedia:Outer_mitochondrial_membrane go.json mitochondrion outer membrane|outer mitochondrial membrane|outer mitochondrion membrane http://purl.obolibrary.org/obo/GO_0005741 GO:0005742 biolink:CellularComponent mitochondrial outer membrane translocase complex A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. go.json GIP complex|mitochondrion outer membrane translocase complex http://purl.obolibrary.org/obo/GO_0005742 GO:0005740 biolink:CellularComponent mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0005740 goslim_candida|goslim_yeast GO:0005749 biolink:CellularComponent mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. go.json mitochondrial fumarate reductase complex http://purl.obolibrary.org/obo/GO_0005749 GO:0005714 biolink:CellularComponent early recombination nodule An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I. go.json http://purl.obolibrary.org/obo/GO_0005714 GO:0005715 biolink:CellularComponent late recombination nodule An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I. go.json http://purl.obolibrary.org/obo/GO_0005715 GO:0005712 biolink:CellularComponent chiasma A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over. Wikipedia:Chiasma_(genetics) go.json http://purl.obolibrary.org/obo/GO_0005712 GO:0005713 biolink:CellularComponent recombination nodule An electron dense structure that is associated with meiotic chromosomes. go.json http://purl.obolibrary.org/obo/GO_0005713 GO:0005710 biolink:CellularComponent obsolete metaphase chromosome OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins. go.json metaphase chromosome True http://purl.obolibrary.org/obo/GO_0005710 GO:0005711 biolink:CellularComponent obsolete meiotic chromosome OBSOLETE. A chromosome involved in the process of meiosis. go.json meiotic chromosome True http://purl.obolibrary.org/obo/GO_0005711 GO:0005718 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005718 GO:0005719 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005719 GO:0005716 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005716 GO:0005717 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005717 GO:0005725 biolink:CellularComponent intercalary heterochromatin Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes. go.json http://purl.obolibrary.org/obo/GO_0005725 GO:0005726 biolink:CellularComponent perichromatin fibrils Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. go.json http://purl.obolibrary.org/obo/GO_0005726 GO:0005723 biolink:CellularComponent alpha-heterochromatin A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization. go.json http://purl.obolibrary.org/obo/GO_0005723 GO:0005724 biolink:CellularComponent obsolete nuclear telomeric heterochromatin OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus. go.json True http://purl.obolibrary.org/obo/GO_0005724 GO:0005721 biolink:CellularComponent pericentric heterochromatin Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). go.json centric heterochromatin|centromeric heterochromatin|chromosome, centric outer repeat region|chromosome, centromeric inner repeat region|chromosome, centromeric outer repeat region|nuclear centric heterochromatin|nuclear cluster|nuclear pericentric heterochromatin http://purl.obolibrary.org/obo/GO_0005721 GO:0005722 biolink:CellularComponent beta-heterochromatin A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization. go.json http://purl.obolibrary.org/obo/GO_0005722 GO:0005720 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005720 GO:0005729 biolink:CellularComponent 2-micrometer circle DNA A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies. go.json http://purl.obolibrary.org/obo/GO_0005729 GO:0005727 biolink:CellularComponent extrachromosomal circular DNA Circular DNA structures that are not part of a chromosome. go.json http://purl.obolibrary.org/obo/GO_0005727 goslim_metagenomics GO:0005728 biolink:CellularComponent extrachromosomal rDNA circle Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats. go.json extrachromosomal ribosomal DNA circle http://purl.obolibrary.org/obo/GO_0005728 GO:0005703 biolink:CellularComponent polytene chromosome puff A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription. go.json http://purl.obolibrary.org/obo/GO_0005703 GO:0005704 biolink:CellularComponent polytene chromosome band A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band. go.json http://purl.obolibrary.org/obo/GO_0005704 GO:0005701 biolink:CellularComponent polytene chromosome chromocenter A region at which the centric regions of polytene chromosomes are joined together. go.json polytene chromosome chromocentre http://purl.obolibrary.org/obo/GO_0005701 GO:0005702 biolink:CellularComponent polytene chromosome weak point A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization. go.json constriction http://purl.obolibrary.org/obo/GO_0005702 GO:0005700 biolink:CellularComponent polytene chromosome A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible. Wikipedia:Polytene_chromosome go.json http://purl.obolibrary.org/obo/GO_0005700 GO:0005709 biolink:CellularComponent obsolete prophase chromosome OBSOLETE. A chromosome found in the cell during prophase. go.json prophase chromosome True http://purl.obolibrary.org/obo/GO_0005709 GO:0005707 biolink:CellularComponent obsolete interphase chromosome OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently. go.json interphase chromosome True http://purl.obolibrary.org/obo/GO_0005707 GO:0005708 biolink:CellularComponent obsolete mitotic chromosome OBSOLETE. A chromosome involved in the process of mitosis. go.json mitotic chromosome True http://purl.obolibrary.org/obo/GO_0005708 GO:0005705 biolink:CellularComponent polytene chromosome interband A stretch of less tightly packed chromatin along the polytene chromosome, found between bands. go.json http://purl.obolibrary.org/obo/GO_0005705 GO:0005706 biolink:CellularComponent polytene chromosome ectopic fiber A thread-like connection joining two regions of ectopically paired polytene chromosomes. go.json polytene chromosome ectopic fibre http://purl.obolibrary.org/obo/GO_0005706 GO:0030778 biolink:MolecularActivity columbamine O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H+ + palmatine. EC:2.1.1.118|KEGG_REACTION:R03721|MetaCyc:2.1.1.118-RXN|RHEA:15373 go.json S-adenosyl-L-methionine:columbamine O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030778 GO:0030779 biolink:MolecularActivity 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H+. EC:2.1.1.119|KEGG_REACTION:R04707|MetaCyc:2.1.1.119-RXN|RHEA:18541 go.json S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030779 GO:0030776 biolink:MolecularActivity (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline. EC:2.1.1.115|MetaCyc:2.1.1.115-RXN|RHEA:13005 go.json (RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity|S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity|norreticuline N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030776 GO:0030777 biolink:MolecularActivity (S)-scoulerine 9-O-methyltransferase activity Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H+. EC:2.1.1.117|KEGG_REACTION:R03835|MetaCyc:2.1.1.117-RXN|RHEA:23808 go.json S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity|S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030777 GO:0030774 biolink:MolecularActivity anthranilate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+. EC:2.1.1.111|KEGG_REACTION:R00984|MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN|RHEA:12180 go.json S-adenosyl-L-methionine:anthranilate N-methyltransferase activity|anthranilic acid N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030774 GO:0030775 biolink:MolecularActivity glucuronoxylan 4-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate. EC:2.1.1.112|MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN|RHEA:20413 go.json S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030775 GO:0015139 biolink:MolecularActivity alpha-ketoglutarate transmembrane transporter activity Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. Reactome:R-HSA-372480 go.json 2-oxoglutarate transporter activity http://purl.obolibrary.org/obo/GO_0015139 GO:0015135 biolink:MolecularActivity glucuronate transmembrane transporter activity Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. go.json http://purl.obolibrary.org/obo/GO_0015135 GO:0015136 biolink:MolecularActivity sialic acid transmembrane transporter activity Enables the transfer of sialic acid from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015136 GO:0015137 biolink:MolecularActivity citrate transmembrane transporter activity Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other. RHEA:33183|Reactome:R-HSA-433104|TC:2.A.29.7.2 go.json tricarboxylate transport protein http://purl.obolibrary.org/obo/GO_0015137 GO:0015138 biolink:MolecularActivity fumarate transmembrane transporter activity Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. go.json dicarboxylate (succinate/fumarate/malate) antiporter activity http://purl.obolibrary.org/obo/GO_0015138 GO:0015131 biolink:MolecularActivity oxaloacetate transmembrane transporter activity Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015131 GO:0030772 biolink:MolecularActivity tryptophan 2-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+. EC:2.1.1.106|KEGG_REACTION:R08547|MetaCyc:RXN-16751|RHEA:17321 go.json S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity|S-adenosylmethionine:tryptophan 2-methyltransferase activity|tryptophan 2-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030772 GO:0015132 biolink:MolecularActivity prostaglandin transmembrane transporter activity Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. Reactome:R-HSA-5661188|Reactome:R-HSA-879528 go.json prostaglandin/thromboxane transporter activity http://purl.obolibrary.org/obo/GO_0015132 GO:0030773 biolink:MolecularActivity 6-hydroxymellein O-methyltransferase activity Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H+. EC:2.1.1.108|KEGG_REACTION:R03934|MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN|RHEA:15201 go.json 6-hydroxymellein methyltransferase activity|S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030773 GO:0015133 biolink:MolecularActivity uronic acid transmembrane transporter activity Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. go.json http://purl.obolibrary.org/obo/GO_0015133 GO:0030770 biolink:MolecularActivity demethylmacrocin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H+ + macrocin. EC:2.1.1.102|KEGG_REACTION:R02859|MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN|RHEA:17573 go.json S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity|demethylmacrocin methyltransferase activity http://purl.obolibrary.org/obo/GO_0030770 GO:0015134 biolink:MolecularActivity hexuronate transmembrane transporter activity Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. go.json hexuronide transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015134 GO:0030771 biolink:MolecularActivity N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H+. EC:2.1.1.105|KEGG_REACTION:R04421|MetaCyc:2.1.1.105-RXN|RHEA:17405 go.json N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity|S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity|benzoyl-CoA:anthranilate N-benzoyltransferase http://purl.obolibrary.org/obo/GO_0030771 GO:0015130 biolink:MolecularActivity mevalonate transmembrane transporter activity Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds. go.json monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity http://purl.obolibrary.org/obo/GO_0015130 GO:0030769 biolink:MolecularActivity macrocin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H+ + tylosin. EC:2.1.1.101|KEGG_REACTION:R02858|MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN|RHEA:17269 go.json S-adenosyl-L-methionine-macrocin O-methyltransferase activity|S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity|macrocin methyltransferase activity http://purl.obolibrary.org/obo/GO_0030769 GO:0030767 biolink:MolecularActivity 3-hydroxyanthranilate 4-C-methyltransferase activity Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H+. EC:2.1.1.97|KEGG_REACTION:R02667|MetaCyc:2.1.1.97-RXN|RHEA:17833 go.json 3-hydroxyanthranilate 4-methyltransferase activity|S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030767 GO:0030768 biolink:MolecularActivity 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H+. EC:2.1.1.99|KEGG_REACTION:R04013|MetaCyc:2.1.1.99-RXN|RHEA:11336 go.json 16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity|3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity|NMT activity|S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity|S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030768 GO:0030765 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030765 GO:0030766 biolink:MolecularActivity 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline. EC:2.1.1.94|MetaCyc:2.1.1.94-RXN|RHEA:20992 go.json 11-demethyl-17-deacetylvindoline 11-methyltransferase activity|S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity|S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity|tabersonine 16-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030766 GO:0030763 biolink:MolecularActivity isobutyraldoxime O-methyltransferase activity Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H+. EC:2.1.1.91|KEGG_REACTION:R04169|MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN|RHEA:10996 go.json S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity|S-adenosylmethionine:aldoxime O-methyltransferase activity|aldoxime O-methyltransferase activity|aldoxime methyltransferase activity http://purl.obolibrary.org/obo/GO_0030763 GO:0030764 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030764 GO:0015146 biolink:MolecularActivity pentose transmembrane transporter activity Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms. go.json http://purl.obolibrary.org/obo/GO_0015146 GO:0015147 biolink:MolecularActivity L-arabinose transmembrane transporter activity Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc. go.json L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015147 GO:0015148 biolink:MolecularActivity D-xylose transmembrane transporter activity Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. go.json http://purl.obolibrary.org/obo/GO_0015148 GO:0015149 biolink:MolecularActivity hexose transmembrane transporter activity Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. Reactome:R-HSA-189242|Reactome:R-HSA-5638222 go.json http://purl.obolibrary.org/obo/GO_0015149 GO:0030761 biolink:MolecularActivity 8-hydroxyquercitin 8-O-methyltransferase activity Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H+. EC:2.1.1.88|KEGG_REACTION:R04398|MetaCyc:2.1.1.88-RXN|RHEA:16593 go.json 8-hydroxyquercetin 8-O-methyltransferase activity|S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity|flavonol 8-O-methyltransferase activity|flavonol 8-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030761 GO:0015142 biolink:MolecularActivity tricarboxylic acid transmembrane transporter activity Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. Reactome:R-HSA-372449|Reactome:R-HSA-75849 go.json sodium:dicarboxylate/tricarboxylate symporter activity http://purl.obolibrary.org/obo/GO_0015142 GO:0015143 biolink:MolecularActivity urate transmembrane transporter activity Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. Reactome:R-HSA-2872497|Reactome:R-HSA-561253|Reactome:R-HSA-5625210 go.json uric acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015143 GO:0030762 biolink:MolecularActivity tetrahydrocolumbamine 2-O-methyltransferase activity Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H+ + tetrahydropalmatine. EC:2.1.1.89|KEGG_REACTION:R04077|MetaCyc:2.1.1.89-RXN|RHEA:22536 go.json S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity|tetrahydrocolumbamine methyltransferase activity http://purl.obolibrary.org/obo/GO_0030762 GO:0015144 biolink:MolecularActivity carbohydrate transmembrane transporter activity Enables the transfer of carbohydrate from one side of a membrane to the other. go.json carbohydrate transporter activity|sugar transporter http://purl.obolibrary.org/obo/GO_0015144 GO:0015145 biolink:MolecularActivity monosaccharide transmembrane transporter activity Enables the transfer of a monosaccharide from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015145 GO:0030760 biolink:MolecularActivity pyridine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine. EC:2.1.1.87|KEGG_REACTION:R02862|MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN|RHEA:16893|Reactome:R-HSA-175987 go.json S-adenosyl-L-methionine:pyridine N-methyltransferase activity|pyridine methyltransferase activity http://purl.obolibrary.org/obo/GO_0030760 GO:0015140 biolink:MolecularActivity malate transmembrane transporter activity Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. go.json dicarboxylate (succinate/fumarate/malate) antiporter activity http://purl.obolibrary.org/obo/GO_0015140 GO:0015141 biolink:MolecularActivity succinate transmembrane transporter activity Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other. go.json dicarboxylate (succinate/fumarate/malate) antiporter activity http://purl.obolibrary.org/obo/GO_0015141 GO:0030758 biolink:MolecularActivity 3,7-dimethylquercitin 4'-O-methyltransferase activity Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+. EC:2.1.1.83|KEGG_REACTION:R03456|MetaCyc:2.1.1.83-RXN|RHEA:21832 go.json 3,7-dimethylquercetin 4'-O-methyltransferase activity|4'-OMT activity|S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity|S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity|flavonol 4'-O-methyltransferase activity|flavonol 4'-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030758 GO:0030759 biolink:MolecularActivity methylquercetagetin 6-O-methyltransferase activity Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+. EC:2.1.1.84|KEGG_REACTION:R04505|MetaCyc:2.1.1.84-RXN|RHEA:18717 go.json 6-OMT|S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity|flavonol 6-O-methyltransferase activity|flavonol 6-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030759 GO:0030756 biolink:MolecularActivity isoorientin 3'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H+ + isoscoparin. EC:2.1.1.78|KEGG_REACTION:R03731|MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN|RHEA:24096 go.json S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity|isoorientin 3'-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030756 GO:0030757 biolink:MolecularActivity 3-methylquercitin 7-O-methyltransferase activity Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine. EC:2.1.1.82|KEGG_REACTION:R05323|MetaCyc:2.1.1.82-RXN|RHEA:16181 go.json 3-methylquercetin 7-O-methyltransferase activity|7-OMT activity|S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity|S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity|flavonol 7-O-methyltransferase activity|flavonol 7-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030757 GO:0030754 biolink:MolecularActivity apigenin 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone. EC:2.1.1.75|MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN|RHEA:20429 go.json S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity|flavonoid O-methyltransferase activity|flavonoid methyltransferase activity http://purl.obolibrary.org/obo/GO_0030754 GO:0005798 biolink:CellularComponent Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. NIF_Subcellular:sao819927218 go.json Golgi vesicle|vesicular component http://purl.obolibrary.org/obo/GO_0005798 GO:0005799 biolink:CellularComponent obsolete coatomer OBSOLETE. (Was not defined before being made obsolete). go.json COPI vesicle|coatomer True http://purl.obolibrary.org/obo/GO_0005799 GO:0030755 biolink:MolecularActivity quercetin 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone. EC:2.1.1.76|MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN|RHEA:17673 go.json S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity|flavonoid 3-methyltransferase activity|flavonol 3-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030755 GO:0030752 biolink:MolecularActivity 5-hydroxyfuranocoumarin 5-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin. EC:2.1.1.69|MetaCyc:2.1.1.69-RXN|RHEA:11808 go.json BMT activity|S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity|S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity|S-adenosyl-L-methionine:bergaptol O-methyltransferase activity|S-adenosyl-L-methionine:bergaptolO-methyltransferase activity|bergaptol 5-O-methyltransferase activity|bergaptol O-methyltransferase activity|bergaptol methyltransferase activity|furanocoumarin 5-O-methyltransferase activity|furanocoumarin 5-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030752 GO:0005796 biolink:CellularComponent Golgi lumen The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. go.json Golgi apparatus lumen http://purl.obolibrary.org/obo/GO_0005796 GO:0030753 biolink:MolecularActivity 8-hydroxyfuranocoumarin 8-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin. EC:2.1.1.70|KEGG_REACTION:R02982 go.json S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity|S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity|S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity|XMT activity|furanocoumarin 8-O-methyl-transferase activity|furanocoumarin 8-methyltransferase activity|xanthotoxol 8-O-methyltransferase activity|xanthotoxol O-methyltransferase activity|xanthotoxol methyltransferase activity http://purl.obolibrary.org/obo/GO_0030753 GO:0005797 biolink:CellularComponent Golgi medial cisterna The middle Golgi cisterna (or cisternae). go.json Golgi apparatus medial cisterna http://purl.obolibrary.org/obo/GO_0005797 GO:0005794 biolink:CellularComponent Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. NIF_Subcellular:sao451912436|Wikipedia:Golgi_apparatus go.json Golgi|Golgi complex|Golgi ribbon http://purl.obolibrary.org/obo/GO_0005794 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast GO:0005795 biolink:CellularComponent Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. go.json Golgi cisternae|dictyosome http://purl.obolibrary.org/obo/GO_0005795 GO:0005792 biolink:CellularComponent obsolete microsome OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g. Wikipedia:Microsome go.json microsomal membrane|microsome True http://purl.obolibrary.org/obo/GO_0005792 GO:0005793 biolink:CellularComponent endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. Wikipedia:Vesicular-tubular_cluster go.json EGTC|ER-Golgi intermediate compartment|ER-Golgi transport container|ERGIC|VTC|endoplasmic reticulum-Golgi transport container|pre-Golgi intermediate compartment|vesicular-tubular cluster http://purl.obolibrary.org/obo/GO_0005793 GO:0005790 biolink:CellularComponent smooth endoplasmic reticulum The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. NIF_Subcellular:sao710427438|Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum go.json SER|smooth ER http://purl.obolibrary.org/obo/GO_0005790 GO:0005791 biolink:CellularComponent rough endoplasmic reticulum The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. NIF_Subcellular:sao1881364067|Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum go.json RER|rough ER http://purl.obolibrary.org/obo/GO_0005791 GO:0015117 biolink:MolecularActivity thiosulfate transmembrane transporter activity Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other. RHEA:32807 go.json thiosulfate permease activity|thiosulphate transporter activity http://purl.obolibrary.org/obo/GO_0015117 GO:0015118 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015118 GO:0015119 biolink:MolecularActivity hexose phosphate transmembrane transporter activity Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule. go.json http://purl.obolibrary.org/obo/GO_0015119 GO:0015113 biolink:MolecularActivity nitrite transmembrane transporter activity Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other. go.json nitrite/nitrate porter activity http://purl.obolibrary.org/obo/GO_0015113 GO:0015114 biolink:MolecularActivity phosphate ion transmembrane transporter activity Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. RHEA:32823 go.json phosphate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015114 GO:0015115 biolink:MolecularActivity silicate transmembrane transporter activity Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. go.json http://purl.obolibrary.org/obo/GO_0015115 GO:0015116 biolink:MolecularActivity sulfate transmembrane transporter activity Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. RHEA:34983|Reactome:R-HSA-3560789|Reactome:R-HSA-427555|Reactome:R-HSA-8875871 go.json sulfate permease activity|sulphate transporter activity http://purl.obolibrary.org/obo/GO_0015116 GO:0030750 biolink:MolecularActivity putrescine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H+. EC:2.1.1.53|KEGG_REACTION:R01153|MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN|RHEA:15037 go.json S-adenosyl-L-methionine:putrescine N-methyltransferase activity|putrescine methyltransferase activity http://purl.obolibrary.org/obo/GO_0030750 GO:0030751 biolink:MolecularActivity licodione 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H+. EC:2.1.1.65|KEGG_REACTION:R03623|MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN|RHEA:18521 go.json S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030751 GO:0015110 biolink:MolecularActivity cyanate transmembrane transporter activity Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015110 GO:0015111 biolink:MolecularActivity iodide transmembrane transporter activity Enables the transfer of iodide ions from one side of a membrane to the other. Reactome:R-HSA-209910|Reactome:R-HSA-5627802|Reactome:R-HSA-5627870 go.json http://purl.obolibrary.org/obo/GO_0015111 GO:0015112 biolink:MolecularActivity nitrate transmembrane transporter activity Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. RHEA:34923 go.json nitrite/nitrate porter activity http://purl.obolibrary.org/obo/GO_0015112 GO:0030747 biolink:MolecularActivity indolepyruvate C-methyltransferase activity Catalysis of the reaction: indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.47|MetaCyc:RXN-17530|RHEA:12112 go.json S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity|S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity|indolepyruvate 3-methyltransferase activity|indolepyruvate methyltransferase activity|indolepyruvic acid methyltransferase activity http://purl.obolibrary.org/obo/GO_0030747 GO:0030748 biolink:MolecularActivity amine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. EC:2.1.1.49|MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN go.json S-adenosyl-L-methionine:amine N-methyltransferase activity|arylamine N-methyltransferase activity|nicotine N-methyltransferase activity|tryptamine N-methyltransferase activity|tryptamine methyltransferase http://purl.obolibrary.org/obo/GO_0030748 GO:0030745 biolink:MolecularActivity dimethylhistidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine. EC:2.1.1.44|KEGG_REACTION:R04436|MetaCyc:2.1.1.44-RXN|RHEA:11104 go.json S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity|S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity|dimethylhistidine methyltransferase activity|histidine-alpha-N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030745 GO:0030746 biolink:MolecularActivity isoflavone 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone. EC:2.1.1.46|MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN|RHEA:31739 go.json 4'-hydroxyisoflavone methyltransferase activity|S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity|isoflavone O-methyltransferase activity|isoflavone methyltransferase activity http://purl.obolibrary.org/obo/GO_0030746 GO:0030743 biolink:MolecularActivity 23S rRNA (adenosine(1067)-2'-O)-methyltransferase activity Catalysis of the reaction: adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.230|MetaCyc:RXN-12464|RHEA:43212 go.json RNA-pentose methylase activity|S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity|rRNA adenosine 2'-methylase activity|ribosomal ribonucleate adenosine 2'-methyltransferase activity|thiostrepton-resistance methylase activity http://purl.obolibrary.org/obo/GO_0030743 GO:0030744 biolink:MolecularActivity luteolin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+. EC:2.1.1.42|KEGG_REACTION:R03587|MetaCyc:RXN-12616|RHEA:14589 go.json S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity|S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity|luteolin 3'-O-methyltransferase activity|luteolin methyltransferase activity|o-dihydric phenol meta-O-methyltransferase activity|o-dihydric phenol methyltransferase activity|o-diphenol m-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030744 GO:0030741 biolink:MolecularActivity inositol 1-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+. EC:2.1.1.40|KEGG_REACTION:R01188|MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN|RHEA:17565 go.json S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity|S-adenosylmethionine:myo-inositol 3-methyltransferase activity|inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)|inositol 3-O-methyltransferase activity|inositol D-1-methyltransferase activity|myo-inositol 3-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030741 GO:0030742 biolink:MolecularActivity GTP-dependent protein binding Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. go.json http://purl.obolibrary.org/obo/GO_0030742 GO:0030749 biolink:MolecularActivity loganate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin. EC:2.1.1.50|MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN|RHEA:12508 go.json S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity|S-adenosyl-L-methionine:loganic acid methyltransferase activity|loganate methyltransferase activity http://purl.obolibrary.org/obo/GO_0030749 GO:0015128 biolink:MolecularActivity gluconate transmembrane transporter activity Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. go.json L-idonate/D-gluconate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015128 GO:0015129 biolink:MolecularActivity lactate transmembrane transporter activity Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. RHEA:34987|Reactome:R-HSA-373867|Reactome:R-HSA-373875 go.json monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity http://purl.obolibrary.org/obo/GO_0015129 GO:0015124 biolink:MolecularActivity allantoate transmembrane transporter activity Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen. go.json http://purl.obolibrary.org/obo/GO_0015124 GO:0015125 biolink:MolecularActivity bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. Reactome:R-HSA-194079|Reactome:R-HSA-194083|Reactome:R-HSA-194130|Reactome:R-HSA-5661184|Reactome:R-HSA-5661198|Reactome:R-HSA-9733964 go.json http://purl.obolibrary.org/obo/GO_0015125 GO:0015126 biolink:MolecularActivity canalicular bile acid transmembrane transporter activity The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. go.json http://purl.obolibrary.org/obo/GO_0015126 GO:0015127 biolink:MolecularActivity bilirubin transmembrane transporter activity Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. Reactome:R-HSA-5679031|Reactome:R-HSA-5679041|Reactome:R-HSA-9661417 go.json http://purl.obolibrary.org/obo/GO_0015127 GO:0015120 biolink:MolecularActivity phosphoglycerate transmembrane transporter activity Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0015120 GO:0030740 biolink:MolecularActivity inositol 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+. EC:2.1.1.39|KEGG_REACTION:R01189|MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN|RHEA:18877 go.json S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity|S-adenosylmethionine:myo-inositol 1-methyltransferase activity|inositol L-1-methyltransferase activity|myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)|myo-inositol 1-O-methyltransferase activity|myo-inositol 1-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030740 GO:0015121 biolink:MolecularActivity phosphoenolpyruvate:phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out). go.json PPT|phosphoenolpyruvate/phosphate translocator http://purl.obolibrary.org/obo/GO_0015121 GO:0015122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015122 GO:0015123 biolink:MolecularActivity acetate transmembrane transporter activity Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. go.json http://purl.obolibrary.org/obo/GO_0015123 GO:0030736 biolink:MolecularActivity phenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H+. EC:2.1.1.25|KEGG_REACTION:R01239|MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN|RHEA:14809 go.json PMT|S-adenosyl-L-methionine:phenol O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030736 GO:0030737 biolink:MolecularActivity iodophenol O-methyltransferase activity Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H+. EC:2.1.1.26|KEGG_REACTION:R03746|MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN|RHEA:14313 go.json S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030737 GO:0030734 biolink:MolecularActivity polysaccharide O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units. EC:2.1.1.18|MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN go.json S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity|acylpolysacharide 6-methyltransferase activity|polysaccharide methyltransferase activity http://purl.obolibrary.org/obo/GO_0030734 GO:0005778 biolink:CellularComponent peroxisomal membrane The lipid bilayer surrounding a peroxisome. go.json peroxisome membrane http://purl.obolibrary.org/obo/GO_0005778 GO:0030735 biolink:MolecularActivity carnosine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+. EC:2.1.1.22|KEGG_REACTION:R02144|MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN|RHEA:14205|Reactome:R-HSA-8876789 go.json S-adenosyl-L-methionine:carnosine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030735 GO:0005779 biolink:CellularComponent obsolete integral component of peroxisomal membrane OBSOLETE. The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to peroxisomal membrane True http://purl.obolibrary.org/obo/GO_0005779 GO:0030732 biolink:MolecularActivity methionine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine. EC:2.1.1.12|MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN|RHEA:13761 go.json S-adenosyl methionine:methionine methyl transferase activity|S-adenosyl-L-methionine:L-methionine S-methyltransferase activity|S-adenosylmethionine transmethylase activity|S-adenosylmethionine-methionine methyltransferase activity|methionine methyltransferase activity http://purl.obolibrary.org/obo/GO_0030732 GO:0005776 biolink:CellularComponent autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. NIF_Subcellular:sao8663416959 go.json autophagic vacuole|initial autophagic vacuole http://purl.obolibrary.org/obo/GO_0005776 GO:0030733 biolink:MolecularActivity fatty acid O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester. EC:2.1.1.15|MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN|RHEA:23012 go.json S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity|fatty acid methyltransferase activity|fatty-acid O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030733 GO:0005777 biolink:CellularComponent peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. NIF_Subcellular:sao499555322|Wikipedia:Peroxisome go.json peroxisomal|peroxisome vesicle http://purl.obolibrary.org/obo/GO_0005777 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_plant|goslim_yeast GO:0030730 biolink:BiologicalProcess sequestering of triglyceride The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. go.json retention of triacylglycerol|retention of triglyceride|sequestering of triacylglycerol|sequestration of triacylglycerol|sequestration of triglyceride|storage of triacylglycerol|storage of triglyceride|triacylglycerol retention|triacylglycerol sequestering|triacylglycerol sequestration|triacylglycerol storage|triglyceride retention|triglyceride sequestering|triglyceride sequestration|triglyceride storage http://purl.obolibrary.org/obo/GO_0030730 GO:0005774 biolink:CellularComponent vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. go.json http://purl.obolibrary.org/obo/GO_0005774 GO:0030731 biolink:MolecularActivity guanidinoacetate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+. EC:2.1.1.2|KEGG_REACTION:R01883|MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN|RHEA:10656 go.json GA methylpherase activity|S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity|guanidinoacetate methyltransferase activity|guanidinoacetate transmethylase activity|guanidoacetate methyltransferase activity|methionine-guanidinoacetic transmethylase activity http://purl.obolibrary.org/obo/GO_0030731 GO:0005775 biolink:CellularComponent vacuolar lumen The volume enclosed within the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0005775 GO:0005772 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005772 GO:0005773 biolink:CellularComponent vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. Wikipedia:Vacuole go.json vacuolar carboxypeptidase Y http://purl.obolibrary.org/obo/GO_0005773 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast GO:0005770 biolink:CellularComponent late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. NIF_Subcellular:nlx_subcell_20090702 go.json PVC|prevacuolar compartment http://purl.obolibrary.org/obo/GO_0005770 GO:0005771 biolink:CellularComponent multivesicular body A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. NIF_Subcellular:sao2045955158 go.json MVB|MVE|multivesicular endosome http://purl.obolibrary.org/obo/GO_0005771 GO:0030738 biolink:MolecularActivity tyramine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+. EC:2.1.1.27|KEGG_REACTION:R02384|MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN|RHEA:14865 go.json DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)|S-adenosyl-L-methionine:tyramine N-methyltransferase activity|S-adenosyl-methionine:tyramine N-methyltransferase activity|tyramine methylpherase activity http://purl.obolibrary.org/obo/GO_0030738 GO:0030739 biolink:MolecularActivity O-demethylpuromycin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin. EC:2.1.1.38|MetaCyc:2.1.1.38-RXN|RHEA:22280 go.json O-demethylpuromycin methyltransferase activity|S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030739 GO:0030725 biolink:BiologicalProcess germline ring canal formation Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts. go.json ring canal formation http://purl.obolibrary.org/obo/GO_0030725 GO:0030726 biolink:BiologicalProcess male germline ring canal formation Formation of the intercellular bridges that connect the germ-line cells of a male cyst. go.json spermatocyte ring canal formation|testicular ring canal formation http://purl.obolibrary.org/obo/GO_0030726 GO:0030723 biolink:BiologicalProcess ovarian fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions. go.json ovarian fusome organisation|ovarian fusome organization and biogenesis http://purl.obolibrary.org/obo/GO_0030723 GO:0005789 biolink:CellularComponent endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. go.json ER membrane http://purl.obolibrary.org/obo/GO_0005789 GO:0030724 biolink:BiologicalProcess testicular fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome. go.json testicular fusome organisation|testicular fusome organization and biogenesis http://purl.obolibrary.org/obo/GO_0030724 GO:0030721 biolink:BiologicalProcess spectrosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome. go.json spectrosome organisation|spectrosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0030721 GO:0005787 biolink:CellularComponent signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. go.json http://purl.obolibrary.org/obo/GO_0005787 GO:0005788 biolink:CellularComponent endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum. go.json ER cisterna|ER lumen|cisternal lumen|endoplasmic reticulum cisterna http://purl.obolibrary.org/obo/GO_0005788 GO:0030722 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030722 GO:0005785 biolink:CellularComponent signal recognition particle receptor complex A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. go.json SR complex|docking protein complex http://purl.obolibrary.org/obo/GO_0005785 GO:0030720 biolink:BiologicalProcess oocyte localization involved in germarium-derived egg chamber formation Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. go.json establishment and maintenance of oocyte localization in egg chamber|establishment and maintenance of oocyte position during oogenesis|oocyte localisation involved in germarium-derived egg chamber formation|oocyte localization during germarium-derived egg chamber formation|oocyte localization during oogenesis|oocyte positioning during oogenesis|oogenesis, establishment and maintenance of oocyte localization|oogenesis, oocyte localization http://purl.obolibrary.org/obo/GO_0030720 GO:0005786 biolink:CellularComponent signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. Wikipedia:Signal_recognition_particle go.json SRP|signal sequence receptor complex http://purl.obolibrary.org/obo/GO_0005786 GO:0005783 biolink:CellularComponent endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). NIF_Subcellular:sao1036339110|Wikipedia:Endoplasmic_reticulum go.json ER http://purl.obolibrary.org/obo/GO_0005783 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast GO:0005784 biolink:CellularComponent Sec61 translocon complex A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events. go.json Sec61p-Sbh1p-Sss1p complex http://purl.obolibrary.org/obo/GO_0005784 GO:0005781 biolink:CellularComponent obsolete peroxisome targeting signal receptor complex OBSOLETE. (Was not defined before being made obsolete). go.json peroxisome targeting signal receptor complex True http://purl.obolibrary.org/obo/GO_0005781 GO:0005782 biolink:CellularComponent peroxisomal matrix The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. go.json peroxisomal lumen http://purl.obolibrary.org/obo/GO_0005782 GO:0030729 biolink:MolecularActivity acetoacetate-CoA ligase activity Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+. EC:6.2.1.16|KEGG_REACTION:R01357|MetaCyc:ACETOACETATE--COA-LIGASE-RXN|RHEA:16117|Reactome:R-HSA-5694494 go.json acetoacetate:CoA ligase (AMP-forming)|acetoacetyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0030729 GO:0005780 biolink:CellularComponent extrinsic component of intraperoxisomal membrane The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to intraperoxisomal membrane|intra-peroxisomal peripheral membrane http://purl.obolibrary.org/obo/GO_0005780 GO:0030727 biolink:BiologicalProcess germarium-derived female germ-line cyst formation Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster. go.json germarium-derived female germline cyst formation http://purl.obolibrary.org/obo/GO_0030727 GO:0030728 biolink:BiologicalProcess ovulation The release of a mature ovum/oocyte from an ovary. Wikipedia:Ovulation go.json http://purl.obolibrary.org/obo/GO_0030728 GO:0015106 biolink:MolecularActivity bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. RHEA:28695|Reactome:R-HSA-2752067 go.json http://purl.obolibrary.org/obo/GO_0015106 GO:0015107 biolink:MolecularActivity chlorate transmembrane transporter activity Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015107 GO:0015108 biolink:MolecularActivity chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other. RHEA:29823|Reactome:R-HSA-5678822|Reactome:R-HSA-5678863|Reactome:R-HSA-5678992 go.json ATP-dependent chloride transmembrane transporter activity|ATPase-coupled chloride transmembrane transporter activity|chloride ABC transporter|chloride ion transmembrane transporter activity|chloride transporting ATPase activity|chloride-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015108 GO:0015109 biolink:MolecularActivity chromate transmembrane transporter activity Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3. RHEA:32819 go.json http://purl.obolibrary.org/obo/GO_0015109 GO:0015103 biolink:MolecularActivity inorganic anion transmembrane transporter activity Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. go.json http://purl.obolibrary.org/obo/GO_0015103 GO:0015104 biolink:MolecularActivity antimonite transmembrane transporter activity Enables the transfer of antimonite from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015104 GO:0015105 biolink:MolecularActivity arsenite transmembrane transporter activity Enables the transfer of arsenite from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015105 GO:0015100 biolink:MolecularActivity vanadium ion transmembrane transporter activity Enables the transfer of vanadium (V) ions from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015100 GO:0015101 biolink:MolecularActivity organic cation transmembrane transporter activity Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. Reactome:R-HSA-2161500|Reactome:R-HSA-549129|Reactome:R-HSA-549279|Reactome:R-HSA-549304|Reactome:R-HSA-549322|Reactome:R-HSA-561054|Reactome:R-HSA-561072|Reactome:R-HSA-9794270|Reactome:R-HSA-9794523|Reactome:R-HSA-9795207 go.json http://purl.obolibrary.org/obo/GO_0015101 GO:0030714 biolink:BiologicalProcess anterior/posterior axis specification, follicular epithelium Polarization of the follicle cells of an insect ovary along the anterior/posterior axis. go.json anterior/posterior axis determination, follicular epithelium http://purl.obolibrary.org/obo/GO_0030714 GO:0005758 biolink:CellularComponent mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope. NIF_Subcellular:sao118944228 go.json mitochondrial envelope lumen|mitochondrial membrane lumen http://purl.obolibrary.org/obo/GO_0005758 GO:0005759 biolink:CellularComponent mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. NIF_Subcellular:sao1804523077|Wikipedia:Mitochondrial_matrix go.json mitochondrial lumen|mitochondrial stroma http://purl.obolibrary.org/obo/GO_0005759 GO:0030715 biolink:BiologicalProcess oocyte growth in germarium-derived egg chamber The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0030715 GO:0030712 biolink:BiologicalProcess negative regulation of border follicle cell delamination Any process that decreases the frequency, rate or extent of border cell delamination. go.json down regulation of border follicle cell delamination|down-regulation of border follicle cell delamination|downregulation of border follicle cell delamination|inhibition of border follicle cell delamination|negative regulation of border cell delamination http://purl.obolibrary.org/obo/GO_0030712 GO:0005756 biolink:CellularComponent mitochondrial proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis. go.json http://purl.obolibrary.org/obo/GO_0005756 GO:0005757 biolink:CellularComponent mitochondrial permeability transition pore complex A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D). go.json MPTP complex|PTPC|mitochondrial PT pore complex http://purl.obolibrary.org/obo/GO_0005757 GO:0030713 biolink:BiologicalProcess follicle cell of egg chamber stalk formation Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0030713 GO:0030710 biolink:BiologicalProcess regulation of border follicle cell delamination Any process that regulates the frequency, rate or extent of border cell delamination. go.json regulation of border cell delamination http://purl.obolibrary.org/obo/GO_0030710 GO:0005754 biolink:CellularComponent mitochondrial proton-transporting ATP synthase, catalytic core The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. go.json http://purl.obolibrary.org/obo/GO_0005754 GO:0030711 biolink:BiologicalProcess positive regulation of border follicle cell delamination Any process that increases the frequency, rate or extent of border cell delamination. go.json activation of border follicle cell delamination|positive regulation of border cell delamination|stimulation of border follicle cell delamination|up regulation of border follicle cell delamination|up-regulation of border follicle cell delamination|upregulation of border follicle cell delamination http://purl.obolibrary.org/obo/GO_0030711 GO:0005755 biolink:CellularComponent obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) OBSOLETE. (Was not defined before being made obsolete). go.json hydrogen-transporting ATP synthase, coupling factor CF(0) True http://purl.obolibrary.org/obo/GO_0005755 GO:0005752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005752 GO:0005753 biolink:CellularComponent mitochondrial proton-transporting ATP synthase complex A proton-transporting ATP synthase complex found in the mitochondrial membrane. go.json mitochondrial respiratory chain complex V http://purl.obolibrary.org/obo/GO_0005753 GO:0005750 biolink:CellularComponent mitochondrial respiratory chain complex III A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. go.json mitochondrial coenzyme Q-cytochrome c oxidoreductase complex|mitochondrial coenzyme Q-cytochrome c reductase complex|mitochondrial complex III|mitochondrial cytochrome bc(1) complex|mitochondrial cytochrome bc1 complex|mitochondrial electron transport complex III|mitochondrial ubiquinol-cytochrome c oxidoreductase complex|mitochondrial ubiquinol-cytochrome-c reductase complex http://purl.obolibrary.org/obo/GO_0005750 GO:0005751 biolink:CellularComponent mitochondrial respiratory chain complex IV A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). go.json http://purl.obolibrary.org/obo/GO_0005751 GO:0030718 biolink:BiologicalProcess germ-line stem cell population maintenance Any process by which an organism or tissue maintains a population of germ-line stem cells. go.json http://purl.obolibrary.org/obo/GO_0030718 GO:0030719 biolink:BiologicalProcess P granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes. go.json P granule organization and biogenesis|polar granule organisation|polar granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0030719 GO:0030716 biolink:BiologicalProcess oocyte fate determination The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json oocyte cell fate determination http://purl.obolibrary.org/obo/GO_0030716 GO:0030717 biolink:BiologicalProcess oocyte karyosome formation The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. go.json http://purl.obolibrary.org/obo/GO_0030717 GO:0005769 biolink:CellularComponent early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. NIF_Subcellular:nlx_subcell_20090701 go.json http://purl.obolibrary.org/obo/GO_0005769 GO:0030703 biolink:BiologicalProcess eggshell formation Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration. go.json http://purl.obolibrary.org/obo/GO_0030703 GO:0030704 biolink:BiologicalProcess vitelline membrane formation Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg. go.json http://purl.obolibrary.org/obo/GO_0030704 GO:0030701 biolink:MolecularActivity NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]. EC:2.4.2.37|MetaCyc:2.4.2.37-RXN|RHEA:18077 go.json ADP-ribosyltransferase activity|NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity|NAD--azoferredoxin (ADP-ribose)transferase activity|NAD-azoferredoxin (ADPribose)transferase activity|NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0030701 GO:0005767 biolink:CellularComponent secondary lysosome Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome. NIF_Subcellular:sao1549842807 go.json http://purl.obolibrary.org/obo/GO_0005767 GO:0005768 biolink:CellularComponent endosome A vacuole to which materials ingested by endocytosis are delivered. NIF_Subcellular:sao1720343330|Wikipedia:Endosome go.json http://purl.obolibrary.org/obo/GO_0005768 goslim_agr|goslim_chembl|goslim_drosophila|goslim_generic|goslim_mouse|goslim_pir|goslim_plant GO:0030702 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030702 GO:0005765 biolink:CellularComponent lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. go.json lysosome membrane http://purl.obolibrary.org/obo/GO_0005765 GO:0030700 biolink:CellularComponent glycine reductase complex Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C. go.json http://purl.obolibrary.org/obo/GO_0030700 GO:0005766 biolink:CellularComponent primary lysosome A lysosome before it has fused with a vesicle or vacuole. NIF_Subcellular:sao1140587416 go.json http://purl.obolibrary.org/obo/GO_0005766 GO:0005763 biolink:CellularComponent mitochondrial small ribosomal subunit The smaller of the two subunits of a mitochondrial ribosome. go.json 28S ribosomal subunit, mitochondrial|mitochondrial ribosomal SSU complex|mitochondrial ribosomal small subunit complex http://purl.obolibrary.org/obo/GO_0005763 GO:0005764 biolink:CellularComponent lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. NIF_Subcellular:sao585356902|Wikipedia:Lysosome go.json http://purl.obolibrary.org/obo/GO_0005764 goslim_chembl|goslim_generic|goslim_plant GO:0005761 biolink:CellularComponent mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. go.json 55S ribosome, mitochondrial http://purl.obolibrary.org/obo/GO_0005761 GO:0005762 biolink:CellularComponent mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). go.json 39S ribosomal subunit, mitochondrial http://purl.obolibrary.org/obo/GO_0005762 GO:0030709 biolink:BiologicalProcess border follicle cell delamination The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration. go.json border cell delamination http://purl.obolibrary.org/obo/GO_0030709 GO:0005760 biolink:CellularComponent gamma DNA polymerase complex A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. go.json http://purl.obolibrary.org/obo/GO_0005760 GO:0030707 biolink:BiologicalProcess follicle cell of egg chamber development The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0030707 GO:0030708 biolink:BiologicalProcess germarium-derived female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0030708 GO:0030705 biolink:BiologicalProcess cytoskeleton-dependent intracellular transport The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. go.json http://purl.obolibrary.org/obo/GO_0030705 goslim_chembl|goslim_drosophila GO:0030706 biolink:BiologicalProcess germarium-derived oocyte differentiation The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster. go.json oocyte cell differentiation http://purl.obolibrary.org/obo/GO_0030706 GO:0015296 biolink:MolecularActivity monoatomic anion:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). go.json anion:cation symporter activity http://purl.obolibrary.org/obo/GO_0015296 GO:0015297 biolink:MolecularActivity antiporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). Reactome:R-HSA-2730692|Reactome:R-HSA-2730959|Reactome:R-HSA-2731002 go.json antiport|countertransporter activity|exchange transporter activity|exchanger|ion antiporter activity|porter|solute:solute antiporter activity|solute:solute exchange http://purl.obolibrary.org/obo/GO_0015297 GO:0015298 biolink:MolecularActivity obsolete solute:monoatomic cation antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). go.json solute:cation antiporter activity True http://purl.obolibrary.org/obo/GO_0015298 GO:0015299 biolink:MolecularActivity obsolete solute:proton antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). go.json L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity|solute:hydrogen antiporter activity True http://purl.obolibrary.org/obo/GO_0015299 GO:0015292 biolink:MolecularActivity uniporter activity Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. go.json facilitated diffusion carrier|single-species transporter activity|uniport http://purl.obolibrary.org/obo/GO_0015292 GO:0015293 biolink:MolecularActivity symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. go.json cotransporter activity|porter activity|symport http://purl.obolibrary.org/obo/GO_0015293 GO:0015294 biolink:MolecularActivity solute:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). go.json solute:cation symporter activity http://purl.obolibrary.org/obo/GO_0015294 GO:0015295 biolink:MolecularActivity solute:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). go.json L-idonate/D-gluconate:hydrogen symporter activity|heavy metal ion:hydrogen symporter activity|high affinity metal ion uptake transporter activity|low affinity metal ion uptake transporter activity|proline/glycine/betaine:hydrogen/sodium symporter activity|solute:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015295 GO:0015280 biolink:MolecularActivity ligand-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. Reactome:R-HSA-2672334 go.json ASIC activity|acid-sensing ion channel activity|amiloride-sensitive sodium channel activity|epithelial sodium channel http://purl.obolibrary.org/obo/GO_0015280 GO:0015278 biolink:MolecularActivity calcium-release channel activity Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. Reactome:R-HSA-9717215 go.json intracellular ligand-gated calcium channel activity http://purl.obolibrary.org/obo/GO_0015278 GO:0015279 biolink:MolecularActivity store-operated calcium channel activity A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. Reactome:R-HSA-434798 go.json http://purl.obolibrary.org/obo/GO_0015279 GO:0015274 biolink:MolecularActivity organellar voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane. go.json organellar voltage gated chloride channel activity|organellar voltage-dependent chloride channel activity http://purl.obolibrary.org/obo/GO_0015274 GO:0015275 biolink:MolecularActivity stretch-activated, monoatomic cation-selective, calcium channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching. go.json stretch-activated, cation-selective, calcium channel activity http://purl.obolibrary.org/obo/GO_0015275 GO:0015276 biolink:MolecularActivity ligand-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. Reactome:R-HSA-451310|Reactome:R-HSA-451311|Reactome:R-HSA-622325|Reactome:R-HSA-622326|Reactome:R-HSA-629595 go.json ionotropic receptor activity|ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0015276 GO:0015277 biolink:MolecularActivity kainate selective glutamate receptor activity An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. go.json http://purl.obolibrary.org/obo/GO_0015277 GO:0015270 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015270 GO:0015271 biolink:MolecularActivity outward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. go.json http://purl.obolibrary.org/obo/GO_0015271 GO:0015272 biolink:MolecularActivity ATP-activated inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. Reactome:R-HSA-5683209 go.json http://purl.obolibrary.org/obo/GO_0015272 GO:0015273 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015273 GO:0015290 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015290 GO:0015291 biolink:MolecularActivity secondary active transmembrane transporter activity Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. TC:2.A go.json active transporter|coupled carrier|electrochemical potential-driven transporter activity|energizer of outer membrane receptor-mediated transport activity|galactose/glucose (methylgalactoside) porter activity|heavy metal ion porter activity|ion-gradient-driven energizer activity|multidrug endosomal transmembrane transporter activity|nitrite/nitrate porter activity|porter activity|porters|secondary carrier-type facilitators http://purl.obolibrary.org/obo/GO_0015291 GO:0015289 biolink:MolecularActivity obsolete pore-forming toxin activity OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell. go.json pore-forming toxin activity True http://purl.obolibrary.org/obo/GO_0015289 GO:0015285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015285 GO:0015286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015286 GO:0015287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015287 GO:0015288 biolink:MolecularActivity porin activity Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. Wikipedia:Porin_(protein) go.json outer membrane exporter porin|porin http://purl.obolibrary.org/obo/GO_0015288 GO:0015281 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015281 GO:0015282 biolink:MolecularActivity obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity OBSOLETE. This term was not defined before being made obsolete. go.json NADPH oxidase-associated cytochrome b558 hydrogen channel activity|NADPH oxidase-associated cytochrome b558 proton channel True http://purl.obolibrary.org/obo/GO_0015282 GO:0015283 biolink:MolecularActivity obsolete apoptogenic cytochrome c release channel activity OBSOLETE. This term was not defined before being made obsolete. go.json Bcl-2|apoptogenic cytochrome c release channel activity True http://purl.obolibrary.org/obo/GO_0015283 GO:0015284 biolink:MolecularActivity fructose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in). go.json http://purl.obolibrary.org/obo/GO_0015284 GO:0005901 biolink:CellularComponent caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. Wikipedia:Caveolae go.json caveolae|caveolar membrane http://purl.obolibrary.org/obo/GO_0005901 GO:0005902 biolink:CellularComponent microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. NIF_Subcellular:sao671419673|Wikipedia:Microvillus go.json microvilli http://purl.obolibrary.org/obo/GO_0005902 goslim_pir GO:0005900 biolink:CellularComponent oncostatin-M receptor complex A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta. go.json http://purl.obolibrary.org/obo/GO_0005900 GO:0005909 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005909 GO:0005907 biolink:CellularComponent obsolete HA1 clathrin adaptor OBSOLETE. (Was not defined before being made obsolete). go.json AP1|HA1 clathrin adaptor True http://purl.obolibrary.org/obo/GO_0005907 GO:0005908 biolink:CellularComponent obsolete HA2 clathrin adaptor OBSOLETE. (Was not defined before being made obsolete). go.json AP2|HA2 clathrin adaptor True http://purl.obolibrary.org/obo/GO_0005908 GO:0005905 biolink:CellularComponent clathrin-coated pit A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. NIF_Subcellular:sao1969557946 go.json coated pit http://purl.obolibrary.org/obo/GO_0005905 GO:0005906 biolink:CellularComponent obsolete clathrin adaptor OBSOLETE. (Was not defined before being made obsolete). go.json adaptin|clathrin adaptor True http://purl.obolibrary.org/obo/GO_0005906 GO:0005903 biolink:CellularComponent brush border The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. Wikipedia:Brush_border go.json http://purl.obolibrary.org/obo/GO_0005903 goslim_pir GO:0005904 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005904 GO:0005857 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005857 GO:0030813 biolink:BiologicalProcess positive regulation of nucleotide catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. go.json activation of nucleotide catabolic process|positive regulation of nucleotide breakdown|positive regulation of nucleotide catabolism|positive regulation of nucleotide degradation|stimulation of nucleotide catabolic process|up regulation of nucleotide catabolic process|up-regulation of nucleotide catabolic process|upregulation of nucleotide catabolic process http://purl.obolibrary.org/obo/GO_0030813 GO:0005858 biolink:CellularComponent axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. go.json axonemal dynein heavy chain|axonemal dynein intermediate chain|axonemal dynein intermediate light chain|axonemal dynein light chain http://purl.obolibrary.org/obo/GO_0005858 GO:0030814 biolink:BiologicalProcess obsolete regulation of cAMP metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json regulation of 3',5' cAMP metabolic process|regulation of 3',5' cAMP metabolism|regulation of 3',5'-cAMP metabolic process|regulation of 3',5'-cAMP metabolism|regulation of adenosine 3',5'-cyclophosphate metabolic process|regulation of adenosine 3',5'-cyclophosphate metabolism|regulation of cAMP metabolism|regulation of cyclic AMP metabolic process|regulation of cyclic AMP metabolism True http://purl.obolibrary.org/obo/GO_0030814 GO:0005855 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005855 GO:0030811 biolink:BiologicalProcess regulation of nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. go.json regulation of nucleotide breakdown|regulation of nucleotide catabolism|regulation of nucleotide degradation http://purl.obolibrary.org/obo/GO_0030811 GO:0030812 biolink:BiologicalProcess negative regulation of nucleotide catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. go.json down regulation of nucleotide catabolic process|down-regulation of nucleotide catabolic process|downregulation of nucleotide catabolic process|inhibition of nucleotide catabolic process|negative regulation of nucleotide breakdown|negative regulation of nucleotide catabolism|negative regulation of nucleotide degradation http://purl.obolibrary.org/obo/GO_0030812 GO:0005856 biolink:CellularComponent cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. Wikipedia:Cytoskeleton go.json http://purl.obolibrary.org/obo/GO_0005856 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0005853 biolink:CellularComponent eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. go.json http://purl.obolibrary.org/obo/GO_0005853 GO:0005854 biolink:CellularComponent nascent polypeptide-associated complex A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. go.json NAC|NACA http://purl.obolibrary.org/obo/GO_0005854 GO:0030810 biolink:BiologicalProcess positive regulation of nucleotide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. go.json activation of nucleotide biosynthetic process|positive regulation of nucleotide anabolism|positive regulation of nucleotide biosynthesis|positive regulation of nucleotide formation|positive regulation of nucleotide synthesis|stimulation of nucleotide biosynthetic process|up regulation of nucleotide biosynthetic process|up-regulation of nucleotide biosynthetic process|upregulation of nucleotide biosynthetic process http://purl.obolibrary.org/obo/GO_0030810 GO:0005851 biolink:CellularComponent eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. go.json eIF-2B|eif2B http://purl.obolibrary.org/obo/GO_0005851 GO:0005852 biolink:CellularComponent eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. go.json eIF-3|eIF3 http://purl.obolibrary.org/obo/GO_0005852 GO:0005850 biolink:CellularComponent eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. Wikipedia:EIF-2 go.json eIF-2|eIF2 http://purl.obolibrary.org/obo/GO_0005850 GO:0030819 biolink:BiologicalProcess obsolete positive regulation of cAMP biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json activation of cAMP biosynthetic process|positive regulation of 3',5' cAMP biosynthesis|positive regulation of 3',5' cAMP biosynthetic process|positive regulation of 3',5'-cAMP biosynthesis|positive regulation of 3',5'-cAMP biosynthetic process|positive regulation of adenosine 3',5'-cyclophosphate biosynthesis|positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process|positive regulation of cAMP anabolism|positive regulation of cAMP biosynthesis|positive regulation of cAMP formation|positive regulation of cAMP synthesis|positive regulation of cyclic AMP biosynthesis|positive regulation of cyclic AMP biosynthetic process|stimulation of cAMP biosynthetic process|up regulation of cAMP biosynthetic process|up-regulation of cAMP biosynthetic process|upregulation of cAMP biosynthetic process True http://purl.obolibrary.org/obo/GO_0030819 GO:0030817 biolink:BiologicalProcess obsolete regulation of cAMP biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json regulation of 3',5' cAMP biosynthesis|regulation of 3',5' cAMP biosynthetic process|regulation of 3',5'-cAMP biosynthesis|regulation of 3',5'-cAMP biosynthetic process|regulation of adenosine 3',5'-cyclophosphate biosynthesis|regulation of adenosine 3',5'-cyclophosphate biosynthetic process|regulation of cAMP anabolism|regulation of cAMP biosynthesis|regulation of cAMP formation|regulation of cAMP synthesis|regulation of cyclic AMP biosynthesis|regulation of cyclic AMP biosynthetic process True http://purl.obolibrary.org/obo/GO_0030817 GO:0030818 biolink:BiologicalProcess obsolete negative regulation of cAMP biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json down regulation of cAMP biosynthetic process|down-regulation of cAMP biosynthetic process|downregulation of cAMP biosynthetic process|inhibition of cAMP biosynthetic process|negative regulation of 3',5' cAMP biosynthesis|negative regulation of 3',5' cAMP biosynthetic process|negative regulation of 3',5'-cAMP biosynthesis|negative regulation of 3',5'-cAMP biosynthetic process|negative regulation of adenosine 3',5'-cyclophosphate biosynthesis|negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process|negative regulation of cAMP anabolism|negative regulation of cAMP biosynthesis|negative regulation of cAMP formation|negative regulation of cAMP synthesis|negative regulation of cyclic AMP biosynthesis|negative regulation of cyclic AMP biosynthetic process True http://purl.obolibrary.org/obo/GO_0030818 GO:0030815 biolink:BiologicalProcess obsolete negative regulation of cAMP metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json down regulation of cAMP metabolic process|down-regulation of cAMP metabolic process|downregulation of cAMP metabolic process|inhibition of cAMP metabolic process|negative regulation of 3',5' cAMP metabolic process|negative regulation of 3',5' cAMP metabolism|negative regulation of 3',5'-cAMP metabolic process|negative regulation of 3',5'-cAMP metabolism|negative regulation of adenosine 3',5'-cyclophosphate metabolic process|negative regulation of adenosine 3',5'-cyclophosphate metabolism|negative regulation of cAMP metabolism|negative regulation of cyclic AMP metabolic process|negative regulation of cyclic AMP metabolism True http://purl.obolibrary.org/obo/GO_0030815 GO:0030816 biolink:BiologicalProcess obsolete positive regulation of cAMP metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json activation of cAMP metabolic process|positive regulation of 3',5' cAMP metabolic process|positive regulation of 3',5' cAMP metabolism|positive regulation of 3',5'-cAMP metabolic process|positive regulation of 3',5'-cAMP metabolism|positive regulation of adenosine 3',5'-cyclophosphate metabolic process|positive regulation of adenosine 3',5'-cyclophosphate metabolism|positive regulation of cAMP metabolism|positive regulation of cyclic AMP metabolic process|positive regulation of cyclic AMP metabolism|stimulation of cAMP metabolic process|up regulation of cAMP metabolic process|up-regulation of cAMP metabolic process|upregulation of cAMP metabolic process True http://purl.obolibrary.org/obo/GO_0030816 GO:0005859 biolink:CellularComponent muscle myosin complex A filament of myosin found in a muscle cell of any type. go.json http://purl.obolibrary.org/obo/GO_0005859 GO:0030802 biolink:BiologicalProcess obsolete regulation of cyclic nucleotide biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides. go.json regulation of cyclic nucleotide anabolism|regulation of cyclic nucleotide biosynthesis|regulation of cyclic nucleotide formation|regulation of cyclic nucleotide synthesis True http://purl.obolibrary.org/obo/GO_0030802 GO:0005868 biolink:CellularComponent cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. go.json cytoplasmic dynein heavy chain|cytoplasmic dynein intermediate chain|cytoplasmic dynein intermediate light chain|cytoplasmic dynein light chain http://purl.obolibrary.org/obo/GO_0005868 GO:0030803 biolink:BiologicalProcess obsolete negative regulation of cyclic nucleotide biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides. go.json down regulation of cyclic nucleotide biosynthetic process|down-regulation of cyclic nucleotide biosynthetic process|downregulation of cyclic nucleotide biosynthetic process|inhibition of cyclic nucleotide biosynthetic process|negative regulation of cyclic nucleotide anabolism|negative regulation of cyclic nucleotide biosynthesis|negative regulation of cyclic nucleotide formation|negative regulation of cyclic nucleotide synthesis True http://purl.obolibrary.org/obo/GO_0030803 GO:0005869 biolink:CellularComponent dynactin complex A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. go.json http://purl.obolibrary.org/obo/GO_0005869 GO:0030800 biolink:BiologicalProcess obsolete negative regulation of cyclic nucleotide metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. go.json down regulation of cyclic nucleotide metabolic process|down-regulation of cyclic nucleotide metabolic process|downregulation of cyclic nucleotide metabolic process|inhibition of cyclic nucleotide metabolic process|negative regulation of cyclic nucleotide metabolism True http://purl.obolibrary.org/obo/GO_0030800 GO:0030801 biolink:BiologicalProcess obsolete positive regulation of cyclic nucleotide metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. go.json activation of cyclic nucleotide metabolic process|positive regulation of cyclic nucleotide metabolism|stimulation of cyclic nucleotide metabolic process|up regulation of cyclic nucleotide metabolic process|up-regulation of cyclic nucleotide metabolic process|upregulation of cyclic nucleotide metabolic process True http://purl.obolibrary.org/obo/GO_0030801 GO:0005865 biolink:CellularComponent striated muscle thin filament Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. go.json http://purl.obolibrary.org/obo/GO_0005865 GO:0005862 biolink:CellularComponent muscle thin filament tropomyosin A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments. go.json http://purl.obolibrary.org/obo/GO_0005862 GO:0005863 biolink:CellularComponent striated muscle myosin thick filament Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils. go.json http://purl.obolibrary.org/obo/GO_0005863 GO:0005860 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005860 GO:0005861 biolink:CellularComponent troponin complex A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0005861 GO:0030808 biolink:BiologicalProcess regulation of nucleotide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. go.json regulation of nucleotide anabolism|regulation of nucleotide biosynthesis|regulation of nucleotide formation|regulation of nucleotide synthesis http://purl.obolibrary.org/obo/GO_0030808 GO:0030809 biolink:BiologicalProcess negative regulation of nucleotide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. go.json down regulation of nucleotide biosynthetic process|down-regulation of nucleotide biosynthetic process|downregulation of nucleotide biosynthetic process|inhibition of nucleotide biosynthetic process|negative regulation of nucleotide anabolism|negative regulation of nucleotide biosynthesis|negative regulation of nucleotide formation|negative regulation of nucleotide synthesis http://purl.obolibrary.org/obo/GO_0030809 GO:0030806 biolink:BiologicalProcess obsolete negative regulation of cyclic nucleotide catabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. go.json down regulation of cyclic nucleotide catabolic process|down-regulation of cyclic nucleotide catabolic process|downregulation of cyclic nucleotide catabolic process|inhibition of cyclic nucleotide catabolic process|negative regulation of cyclic nucleotide breakdown|negative regulation of cyclic nucleotide catabolism|negative regulation of cyclic nucleotide degradation True http://purl.obolibrary.org/obo/GO_0030806 GO:0030807 biolink:BiologicalProcess obsolete positive regulation of cyclic nucleotide catabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. go.json activation of cyclic nucleotide catabolic process|positive regulation of cyclic nucleotide breakdown|positive regulation of cyclic nucleotide catabolism|positive regulation of cyclic nucleotide degradation|stimulation of cyclic nucleotide catabolic process|up regulation of cyclic nucleotide catabolic process|up-regulation of cyclic nucleotide catabolic process|upregulation of cyclic nucleotide catabolic process True http://purl.obolibrary.org/obo/GO_0030807 GO:0030804 biolink:BiologicalProcess obsolete positive regulation of cyclic nucleotide biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides. go.json activation of cyclic nucleotide biosynthetic process|positive regulation of cyclic nucleotide anabolism|positive regulation of cyclic nucleotide biosynthesis|positive regulation of cyclic nucleotide formation|positive regulation of cyclic nucleotide synthesis|stimulation of cyclic nucleotide biosynthetic process|up regulation of cyclic nucleotide biosynthetic process|up-regulation of cyclic nucleotide biosynthetic process|upregulation of cyclic nucleotide biosynthetic process True http://purl.obolibrary.org/obo/GO_0030804 GO:0030805 biolink:BiologicalProcess regulation of cyclic nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. go.json regulation of cyclic nucleotide breakdown|regulation of cyclic nucleotide catabolism|regulation of cyclic nucleotide degradation http://purl.obolibrary.org/obo/GO_0030805 GO:0005835 biolink:CellularComponent fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. Wikipedia:Fatty_acid_synthetase_complex go.json FAS complex|cytosolic FAS complex|cytosolic fatty acid synthase complex|cytosolic type I FAS complex|cytosolic type I fatty acid synthase complex|fatty acid synthetase complex|holo-[acyl-carrier-protein] synthase complex http://purl.obolibrary.org/obo/GO_0005835 goslim_pir GO:0005836 biolink:CellularComponent fatty-acyl-CoA synthase complex A protein complex that possesses fatty-acyl-CoA synthase activity. go.json fatty acyl CoA synthase complex http://purl.obolibrary.org/obo/GO_0005836 GO:0005833 biolink:CellularComponent hemoglobin complex An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. go.json haemoglobin complex http://purl.obolibrary.org/obo/GO_0005833 GO:0005834 biolink:CellularComponent heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. go.json heterotrimeric G-protein GTPase activity|heterotrimeric G-protein GTPase, alpha-subunit|heterotrimeric G-protein GTPase, beta-subunit|heterotrimeric G-protein GTPase, gamma-subunit http://purl.obolibrary.org/obo/GO_0005834 GO:0005831 biolink:CellularComponent steroid hormone aporeceptor complex A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand. go.json http://purl.obolibrary.org/obo/GO_0005831 GO:0005832 biolink:CellularComponent chaperonin-containing T-complex A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. go.json CCT particle|TriC http://purl.obolibrary.org/obo/GO_0005832 GO:0005830 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005830 GO:0005839 biolink:CellularComponent proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. go.json 20S core complex|20S proteasome|PA28gamma-20S proteasome|macropain http://purl.obolibrary.org/obo/GO_0005839 goslim_metagenomics GO:0005837 biolink:CellularComponent obsolete 26S proteasome OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome. go.json 26S proteasome True http://purl.obolibrary.org/obo/GO_0005837 GO:0005838 biolink:CellularComponent proteasome regulatory particle A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. go.json 19S regulatory particle|PA700 proteasome activator|PA700-dependent proteasome activator|modulator complex http://purl.obolibrary.org/obo/GO_0005838 GO:0005846 biolink:CellularComponent nuclear cap binding complex A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. go.json CBC|NCBP-NIP1 complex|mRNA cap binding complex|nuclear CBC|snRNA cap binding complex http://purl.obolibrary.org/obo/GO_0005846 GO:0005847 biolink:CellularComponent mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. go.json CFII complex|CPF complex|CPSF complex|cleavage and polyadenylylation specificity factor activity http://purl.obolibrary.org/obo/GO_0005847 GO:0005844 biolink:CellularComponent polysome A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. NIF_Subcellular:sao1038025871|Wikipedia:Polysome go.json polyribosome http://purl.obolibrary.org/obo/GO_0005844 goslim_pir GO:0005845 biolink:CellularComponent mRNA cap binding complex Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. go.json mRNA cap complex http://purl.obolibrary.org/obo/GO_0005845 GO:0005842 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005842 GO:0005843 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005843 GO:0005840 biolink:CellularComponent ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. NIF_Subcellular:sao1429207766|Wikipedia:Ribosome go.json free ribosome|membrane bound ribosome|ribosomal RNA http://purl.obolibrary.org/obo/GO_0005840 goslim_candida|goslim_chembl|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0005848 biolink:CellularComponent mRNA cleavage stimulating factor complex A protein complex required for mRNA cleavage but not for poly(A) addition. go.json CstF complex|cleavage stimulation factor activity http://purl.obolibrary.org/obo/GO_0005848 GO:0005849 biolink:CellularComponent mRNA cleavage factor complex Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. go.json http://purl.obolibrary.org/obo/GO_0005849 goslim_pir GO:0005813 biolink:CellularComponent centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. Wikipedia:Centrosome go.json http://purl.obolibrary.org/obo/GO_0005813 goslim_pir GO:0005814 biolink:CellularComponent centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. NIF_Subcellular:sao95019936|Wikipedia:Centriole go.json daughter centriole|mother centriole http://purl.obolibrary.org/obo/GO_0005814 GO:0005811 biolink:CellularComponent lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. go.json adiposome|lipid body|lipid particle http://purl.obolibrary.org/obo/GO_0005811 goslim_chembl|goslim_generic GO:0005810 biolink:CellularComponent obsolete endocytotic transport vesicle OBSOLETE. (Was not defined before being made obsolete). go.json endocytotic transport vesicle True http://purl.obolibrary.org/obo/GO_0005810 GO:0005819 biolink:CellularComponent spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. Wikipedia:Spindle_apparatus go.json http://purl.obolibrary.org/obo/GO_0005819 GO:0005817 biolink:CellularComponent obsolete centrosomal mitotic factor OBSOLETE. (Was not defined before being made obsolete). go.json centrosomal mitotic factor True http://purl.obolibrary.org/obo/GO_0005817 GO:0005818 biolink:CellularComponent aster An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores. go.json http://purl.obolibrary.org/obo/GO_0005818 GO:0005815 biolink:CellularComponent microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. Wikipedia:Microtubule_organizing_center go.json MTOC|microtubule organising centre http://purl.obolibrary.org/obo/GO_0005815 goslim_candida|goslim_chembl|goslim_generic|goslim_yeast GO:0005816 biolink:CellularComponent spindle pole body The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. Wikipedia:Spindle_pole_body go.json SPB http://purl.obolibrary.org/obo/GO_0005816 GO:0005824 biolink:CellularComponent outer plaque of spindle pole body One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0005824 GO:0005825 biolink:CellularComponent half bridge of spindle pole body Structure adjacent to the plaques of the spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0005825 GO:0005822 biolink:CellularComponent inner plaque of spindle pole body One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus. go.json http://purl.obolibrary.org/obo/GO_0005822 GO:0005823 biolink:CellularComponent central plaque of spindle pole body One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope. go.json http://purl.obolibrary.org/obo/GO_0005823 GO:0005821 biolink:CellularComponent intermediate layer of spindle pole body Structure between the central and outer plaques of the spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0005821 GO:0005828 biolink:CellularComponent kinetochore microtubule Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. go.json pole-to-kinetochore microtubule http://purl.obolibrary.org/obo/GO_0005828 GO:0005829 biolink:CellularComponent cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. NIF_Subcellular:sao101633890|Wikipedia:Cytosol go.json http://purl.obolibrary.org/obo/GO_0005829 goslim_agr|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_plant GO:0005826 biolink:CellularComponent actomyosin contractile ring A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis. go.json CAR|actomyosin ring|constriction ring|contractile actomyosin ring|cytokinetic ring http://purl.obolibrary.org/obo/GO_0005826 GO:0005827 biolink:CellularComponent polar microtubule Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. go.json pole-to-pole microtubule http://purl.obolibrary.org/obo/GO_0005827 GO:0005802 biolink:CellularComponent trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. NIF_Subcellular:sao9456487 go.json Golgi trans face|Golgi trans-face|TGN|late Golgi|maturing face|trans Golgi network|trans face http://purl.obolibrary.org/obo/GO_0005802 GO:0005803 biolink:CellularComponent obsolete secretory vesicle OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. go.json secretory vesicle|transition vesicle True http://purl.obolibrary.org/obo/GO_0005803 GO:0005800 biolink:CellularComponent obsolete COPII vesicle OBSOLETE. (Was not defined before being made obsolete). go.json COPII vesicle True http://purl.obolibrary.org/obo/GO_0005800 GO:0005801 biolink:CellularComponent cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. NIF_Subcellular:sao632188024 go.json Golgi cis face|Golgi cis-face|cis Golgi network|cis face|forming face http://purl.obolibrary.org/obo/GO_0005801 GO:0005808 biolink:CellularComponent obsolete Golgi-plasma membrane transport vesicle OBSOLETE. (Was not defined before being made obsolete). go.json Golgi-plasma membrane transport vesicle True http://purl.obolibrary.org/obo/GO_0005808 GO:0005809 biolink:CellularComponent obsolete Golgi-vacuole transport vesicle OBSOLETE. (Was not defined before being made obsolete). go.json Golgi-vacuole transport vesicle True http://purl.obolibrary.org/obo/GO_0005809 GO:0005806 biolink:CellularComponent obsolete Golgi-ER transport vesicle OBSOLETE. (Was not defined before being made obsolete). go.json Golgi-ER transport vesicle True http://purl.obolibrary.org/obo/GO_0005806 GO:0005807 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005807 GO:0005804 biolink:CellularComponent obsolete secretory vesicle membrane OBSOLETE. (Was not defined before being made obsolete). go.json secretory vesicle membrane True http://purl.obolibrary.org/obo/GO_0005804 GO:0005805 biolink:CellularComponent obsolete ER-Golgi transport vesicle OBSOLETE. (Was not defined before being made obsolete). go.json ER-Golgi transport vesicle True http://purl.obolibrary.org/obo/GO_0005805 GO:0030899 biolink:MolecularActivity calcium-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). go.json http://purl.obolibrary.org/obo/GO_0030899 GO:0030897 biolink:CellularComponent HOPS complex A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. go.json http://purl.obolibrary.org/obo/GO_0030897 GO:0030898 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030898 GO:0030895 biolink:CellularComponent apolipoprotein B mRNA editing enzyme complex Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP). go.json APOBEC|apoB mRNA editing enzyme complex http://purl.obolibrary.org/obo/GO_0030895 GO:0030896 biolink:CellularComponent checkpoint clamp complex Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. go.json CCC|Rad9-Hus1-Rad1 (9-1-1) clamp complex http://purl.obolibrary.org/obo/GO_0030896 GO:0015256 biolink:MolecularActivity obsolete monocarboxylate channel activity OBSOLETE. This term was not defined before being made obsolete. go.json monocarboxylate channel activity True http://purl.obolibrary.org/obo/GO_0015256 GO:0015257 biolink:MolecularActivity obsolete organic anion channel activity OBSOLETE. This term was not defined before being made obsolete. go.json organic anion channel activity True http://purl.obolibrary.org/obo/GO_0015257 GO:0015258 biolink:MolecularActivity obsolete gluconate channel activity OBSOLETE. This term was not defined before being made obsolete. go.json gluconate channel activity True http://purl.obolibrary.org/obo/GO_0015258 GO:0015259 biolink:MolecularActivity obsolete glutamate channel activity OBSOLETE. This term was not defined before being made obsolete. go.json glutamate channel activity True http://purl.obolibrary.org/obo/GO_0015259 GO:0030893 biolink:CellularComponent meiotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. go.json nuclear meiotic cohesin complex http://purl.obolibrary.org/obo/GO_0030893 GO:0015252 biolink:MolecularActivity proton channel activity Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Reactome:R-HSA-9729542 go.json hydrogen ion channel activity http://purl.obolibrary.org/obo/GO_0015252 GO:0030894 biolink:CellularComponent replisome A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. Wikipedia:Replisome go.json DNA synthesome complex|RC complex|replication-competent complex http://purl.obolibrary.org/obo/GO_0030894 goslim_pir GO:0015253 biolink:MolecularActivity obsolete sugar/polyol channel activity OBSOLETE. (Was not defined before being made obsolete). go.json sugar/polyol channel activity True http://purl.obolibrary.org/obo/GO_0015253 GO:0015254 biolink:MolecularActivity glycerol channel activity Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. RHEA:29675|Reactome:R-HSA-432049|Reactome:R-HSA-432074|Reactome:R-HSA-507869|Reactome:R-HSA-507871 go.json http://purl.obolibrary.org/obo/GO_0015254 GO:0030891 biolink:CellularComponent VCB complex A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1. go.json VHL complex|pVHL-elongin C-elongin B complex|von Hippel-Lindau tumor suppressor complex http://purl.obolibrary.org/obo/GO_0030891 GO:0030892 biolink:CellularComponent mitotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. go.json nuclear mitotic cohesin complex http://purl.obolibrary.org/obo/GO_0030892 GO:0015255 biolink:MolecularActivity propanediol channel activity Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. go.json http://purl.obolibrary.org/obo/GO_0015255 GO:0030890 biolink:BiologicalProcess positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation. go.json activation of B cell proliferation|positive regulation of B lymphocyte proliferation|positive regulation of B-cell proliferation|positive regulation of B-lymphocyte proliferation|stimulation of B cell proliferation|up regulation of B cell proliferation|up-regulation of B cell proliferation|upregulation of B cell proliferation http://purl.obolibrary.org/obo/GO_0030890 GO:0015250 biolink:MolecularActivity water channel activity Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. RHEA:29667|Reactome:R-HSA-432010|Reactome:R-HSA-432054|Reactome:R-HSA-432065|Reactome:R-HSA-432067|Reactome:R-HSA-445714|Reactome:R-HSA-507868|Reactome:R-HSA-507870 go.json aquaporin http://purl.obolibrary.org/obo/GO_0015250 GO:0015251 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015251 GO:0030888 biolink:BiologicalProcess regulation of B cell proliferation Any process that modulates the frequency, rate or extent of B cell proliferation. go.json regulation of B lymphocyte proliferation|regulation of B-cell proliferation|regulation of B-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0030888 GO:0030889 biolink:BiologicalProcess negative regulation of B cell proliferation Any process that stops, prevents or reduces the rate or extent of B cell proliferation. go.json down regulation of B cell proliferation|down-regulation of B cell proliferation|downregulation of B cell proliferation|inhibition of B cell proliferation|negative regulation of B lymphocyte proliferation|negative regulation of B-cell proliferation|negative regulation of B-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0030889 GO:0030886 biolink:BiologicalProcess negative regulation of myeloid dendritic cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. go.json down regulation of myeloid dendritic cell activation|down-regulation of myeloid dendritic cell activation|downregulation of myeloid dendritic cell activation|inhibition of myeloid dendritic cell activation http://purl.obolibrary.org/obo/GO_0030886 GO:0030887 biolink:BiologicalProcess positive regulation of myeloid dendritic cell activation Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. go.json activation of myeloid dendritic cell activation|stimulation of myeloid dendritic cell activation|up regulation of myeloid dendritic cell activation|up-regulation of myeloid dendritic cell activation|upregulation of myeloid dendritic cell activation http://purl.obolibrary.org/obo/GO_0030887 GO:0030884 biolink:MolecularActivity exogenous lipid antigen binding Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids). go.json http://purl.obolibrary.org/obo/GO_0030884 GO:0030885 biolink:BiologicalProcess regulation of myeloid dendritic cell activation Any process that modulates the frequency or rate of myeloid dendritic cell activation. go.json http://purl.obolibrary.org/obo/GO_0030885 GO:0015267 biolink:MolecularActivity channel activity Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. Reactome:R-HSA-3779381|Reactome:R-HSA-8953430|TC:1 go.json alpha-type channel activity|channel-forming toxin activity|channel/pore class transporter activity|nonselective channel activity|pore activity|pore class transporter activity|substrate-specific channel activity http://purl.obolibrary.org/obo/GO_0015267 GO:0015268 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015268 GO:0015269 biolink:MolecularActivity calcium-activated potassium channel activity Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. Reactome:R-HSA-9663752|Reactome:R-HSA-9667809 go.json http://purl.obolibrary.org/obo/GO_0015269 GO:0015263 biolink:MolecularActivity obsolete amine/amide/polyamine channel activity OBSOLETE. (Was not defined before being made obsolete). go.json amine/amide/polyamine channel activity True http://purl.obolibrary.org/obo/GO_0015263 GO:0030882 biolink:MolecularActivity lipid antigen binding Binding to a lipid antigen. go.json http://purl.obolibrary.org/obo/GO_0030882 GO:0015264 biolink:MolecularActivity methylammonium channel activity Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2. go.json http://purl.obolibrary.org/obo/GO_0015264 GO:0030883 biolink:MolecularActivity endogenous lipid antigen binding Binding to an endogenous cellular lipid antigen. go.json http://purl.obolibrary.org/obo/GO_0030883 GO:0015265 biolink:MolecularActivity urea channel activity Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Reactome:R-HSA-507873|Reactome:R-HSA-507875 go.json http://purl.obolibrary.org/obo/GO_0015265 GO:0030880 biolink:CellularComponent RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. go.json multisubunit RNA polymerase http://purl.obolibrary.org/obo/GO_0030880 goslim_pir GO:0015266 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015266 GO:0030881 biolink:MolecularActivity beta-2-microglobulin binding Binding to beta-2-microglobulin. go.json http://purl.obolibrary.org/obo/GO_0030881 goslim_chembl GO:0015260 biolink:MolecularActivity obsolete isethionate channel activity OBSOLETE. This term was not defined before being made obsolete. go.json isethionate channel activity True http://purl.obolibrary.org/obo/GO_0015260 GO:0015261 biolink:MolecularActivity obsolete lactate channel activity OBSOLETE. This term was not defined before being made obsolete. go.json lactate channel activity True http://purl.obolibrary.org/obo/GO_0015261 GO:0015262 biolink:MolecularActivity obsolete taurine channel activity OBSOLETE. This term was not defined before being made obsolete. go.json taurine channel activity True http://purl.obolibrary.org/obo/GO_0015262 GO:0030879 biolink:BiologicalProcess mammary gland development The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. go.json mammogenesis http://purl.obolibrary.org/obo/GO_0030879 GO:0030877 biolink:CellularComponent beta-catenin destruction complex A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. go.json 23S APC complex|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|BDC|beta-catenin degradation complex http://purl.obolibrary.org/obo/GO_0030877 GO:0030878 biolink:BiologicalProcess thyroid gland development The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. go.json http://purl.obolibrary.org/obo/GO_0030878 GO:0030875 biolink:CellularComponent rDNA protrusion Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining. go.json ribosomal DNA protrusion http://purl.obolibrary.org/obo/GO_0030875 GO:0030876 biolink:CellularComponent interleukin-20 receptor complex A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits. go.json IL-20 receptor complex http://purl.obolibrary.org/obo/GO_0030876 GO:0030873 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030873 GO:0030874 biolink:CellularComponent nucleolar chromatin The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA. go.json http://purl.obolibrary.org/obo/GO_0030874 GO:0015238 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015238 GO:0015239 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015239 GO:0015234 biolink:MolecularActivity thiamine transmembrane transporter activity Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. RHEA:34919|Reactome:R-HSA-199626 go.json thiamin permease activity|thiamin transmembrane transporter activity|thiamin uptake transporter activity|thiamine permease activity|thiamine uptake transmembrane transporter activity|vitamin B1 transporter activity http://purl.obolibrary.org/obo/GO_0015234 GO:0015235 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015235 GO:0015236 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015236 GO:0015237 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015237 GO:0015230 biolink:MolecularActivity FAD transmembrane transporter activity Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. go.json FAD carrier activity|FAD transporter activity|flavin adenine dinucleotide carrier activity|flavin adenine dinucleotide transmembrane transporter activity|flavin-adenine dinucleotide carrier activity|flavin-adenine dinucleotide transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015230 GO:0030871 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030871 GO:0015231 biolink:MolecularActivity 5-formyltetrahydrofolate transmembrane transporter activity Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other. go.json 5-formyltetrahydrofolate transporter activity http://purl.obolibrary.org/obo/GO_0015231 GO:0030872 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030872 GO:0015232 biolink:MolecularActivity heme transmembrane transporter activity Enables the transfer of heme from one side of a membrane to the other. Reactome:R-HSA-917870|Reactome:R-HSA-917892|Reactome:R-HSA-9661408 go.json haem transporter activity|heme transporter activity http://purl.obolibrary.org/obo/GO_0015232 GO:0030870 biolink:CellularComponent Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. go.json MRN complex|MRX complex|RAD50-MRE11-NBN complex|RMX complex|Rad50 complex|Rad50-Rad32-Nbs1 complex http://purl.obolibrary.org/obo/GO_0030870 GO:0015233 biolink:MolecularActivity pantothenate transmembrane transporter activity Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. go.json pantothenate transporter activity|vitamin B5 transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015233 GO:0030868 biolink:CellularComponent smooth endoplasmic reticulum membrane The lipid bilayer surrounding the smooth endoplasmic reticulum. NIF_Subcellular:sao1596955044 go.json SER membrane|smooth ER membrane http://purl.obolibrary.org/obo/GO_0030868 GO:0030869 biolink:CellularComponent RENT complex A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit. go.json http://purl.obolibrary.org/obo/GO_0030869 GO:0030866 biolink:BiologicalProcess cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. go.json actin cortex stabilization|cortical actin cytoskeleton organisation|cortical actin cytoskeleton organization and biogenesis|cortical actin cytoskeleton stabilization|cortical resistance http://purl.obolibrary.org/obo/GO_0030866 GO:0030867 biolink:CellularComponent rough endoplasmic reticulum membrane The lipid bilayer surrounding the rough endoplasmic reticulum. NIF_Subcellular:sao3089754107 go.json RER membrane|rough ER membrane http://purl.obolibrary.org/obo/GO_0030867 GO:0030864 biolink:CellularComponent cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0030864 GO:0030865 biolink:BiologicalProcess cortical cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. go.json cortical cytoskeleton organisation|cortical cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0030865 GO:0030862 biolink:BiologicalProcess positive regulation of polarized epithelial cell differentiation Any process that activates or increases the rate or extent of polarized epithelial cell differentiation. go.json activation of polarized epithelial cell differentiation|stimulation of polarized epithelial cell differentiation|up regulation of polarized epithelial cell differentiation|up-regulation of polarized epithelial cell differentiation|upregulation of polarized epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0030862 GO:0030863 biolink:CellularComponent cortical cytoskeleton The portion of the cytoskeleton that lies just beneath the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0030863 GO:0015249 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015249 GO:0015245 biolink:MolecularActivity fatty acid transmembrane transporter activity Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. Reactome:R-HSA-5627891|Reactome:R-HSA-879585 go.json fatty acid transporter activity|fatty acyl transporter activity|fatty-acyl group transporter activity|peroxisomal fatty acyl transporter http://purl.obolibrary.org/obo/GO_0015245 GO:0015246 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015246 GO:0015247 biolink:MolecularActivity aminophospholipid flippase activity Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. go.json aminophospholipid transmembrane transporter activity|aminophospholipid transporter activity http://purl.obolibrary.org/obo/GO_0015247 GO:0015248 biolink:MolecularActivity sterol transporter activity Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. RHEA:39747|Reactome:R-HSA-265783|Reactome:R-HSA-5250531|Reactome:R-HSA-5679101|Reactome:R-HSA-5679145|Reactome:R-HSA-8867667|Reactome:R-HSA-8868402 go.json http://purl.obolibrary.org/obo/GO_0015248 GO:0030860 biolink:BiologicalProcess regulation of polarized epithelial cell differentiation Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0030860 GO:0015241 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015241 GO:0030861 biolink:BiologicalProcess negative regulation of polarized epithelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation. go.json down regulation of polarized epithelial cell differentiation|down-regulation of polarized epithelial cell differentiation|downregulation of polarized epithelial cell differentiation|inhibition of polarized epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0030861 GO:0015242 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015242 GO:0015243 biolink:MolecularActivity cycloheximide transmembrane transporter activity Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. go.json cycloheximide transporter activity http://purl.obolibrary.org/obo/GO_0015243 GO:0015244 biolink:MolecularActivity fluconazole transmembrane transporter activity Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. go.json fluconazole transporter activity http://purl.obolibrary.org/obo/GO_0015244 GO:0015240 biolink:MolecularActivity obsolete amiloride transmembrane transporter activity OBSOLETE. Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. go.json amiloride transporter activity True http://purl.obolibrary.org/obo/GO_0015240 GO:0030857 biolink:BiologicalProcess negative regulation of epithelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. go.json down regulation of epithelial cell differentiation|down-regulation of epithelial cell differentiation|downregulation of epithelial cell differentiation|inhibition of epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0030857 GO:0030858 biolink:BiologicalProcess positive regulation of epithelial cell differentiation Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. go.json activation of epithelial cell differentiation|stimulation of epithelial cell differentiation|up regulation of epithelial cell differentiation|up-regulation of epithelial cell differentiation|upregulation of epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0030858 GO:0005899 biolink:CellularComponent insulin receptor complex A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain. go.json http://purl.obolibrary.org/obo/GO_0005899 GO:0030855 biolink:BiologicalProcess epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. go.json http://purl.obolibrary.org/obo/GO_0030855 GO:0030856 biolink:BiologicalProcess regulation of epithelial cell differentiation Any process that modulates the frequency, rate or extent of epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0030856 GO:0030853 biolink:BiologicalProcess negative regulation of granulocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. go.json down regulation of granulocyte differentiation|down-regulation of granulocyte differentiation|downregulation of granulocyte differentiation|inhibition of granulocyte differentiation http://purl.obolibrary.org/obo/GO_0030853 GO:0005897 biolink:CellularComponent interleukin-9 receptor complex A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins. go.json IL-9 receptor complex http://purl.obolibrary.org/obo/GO_0005897 GO:0030854 biolink:BiologicalProcess positive regulation of granulocyte differentiation Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. go.json activation of granulocyte differentiation|stimulation of granulocyte differentiation|up regulation of granulocyte differentiation|up-regulation of granulocyte differentiation|upregulation of granulocyte differentiation http://purl.obolibrary.org/obo/GO_0030854 GO:0005898 biolink:CellularComponent interleukin-13 receptor complex A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain. go.json IL-13 receptor complex http://purl.obolibrary.org/obo/GO_0005898 GO:0005895 biolink:CellularComponent interleukin-5 receptor complex A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3. go.json IL-5 receptor complex http://purl.obolibrary.org/obo/GO_0005895 GO:0030851 biolink:BiologicalProcess granulocyte differentiation The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. go.json granulocyte cell differentiation http://purl.obolibrary.org/obo/GO_0030851 GO:0030852 biolink:BiologicalProcess regulation of granulocyte differentiation Any process that modulates the frequency, rate or extent of granulocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0030852 GO:0005896 biolink:CellularComponent interleukin-6 receptor complex A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130. go.json IL-6 receptor complex http://purl.obolibrary.org/obo/GO_0005896 GO:0005893 biolink:CellularComponent interleukin-2 receptor complex A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits. go.json IL-2 receptor complex http://purl.obolibrary.org/obo/GO_0005893 GO:0005894 biolink:CellularComponent interleukin-3 receptor complex A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5. go.json IL-3 receptor complex http://purl.obolibrary.org/obo/GO_0005894 GO:0005891 biolink:CellularComponent voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. go.json voltage gated calcium channel complex|voltage-dependent calcium channel complex|voltage-sensitive calcium channel complex http://purl.obolibrary.org/obo/GO_0005891 goslim_pir GO:0005892 biolink:CellularComponent acetylcholine-gated channel complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. go.json nicotinic acetylcholine receptor|nicotinic acetylcholine-gated receptor-channel complex http://purl.obolibrary.org/obo/GO_0005892 GO:0005890 biolink:CellularComponent sodium:potassium-exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. go.json sodium pump|sodium/potassium-exchanging ATPase complex http://purl.obolibrary.org/obo/GO_0005890 GO:0030859 biolink:BiologicalProcess polarized epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. go.json http://purl.obolibrary.org/obo/GO_0030859 GO:0015216 biolink:MolecularActivity purine nucleotide transmembrane transporter activity Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015216 GO:0015217 biolink:MolecularActivity ADP transmembrane transporter activity Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015217 GO:0015218 biolink:MolecularActivity pyrimidine nucleotide transmembrane transporter activity Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015218 GO:0015219 biolink:MolecularActivity obsolete protein-DNA complex transmembrane transporter activity OBSOLETE. Enables the transfer of protein-DNA complexes from one side of a membrane to the other. go.json DNA-protein complex transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_0015219 GO:0015212 biolink:MolecularActivity cytidine transmembrane transporter activity Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015212 GO:0015213 biolink:MolecularActivity uridine transmembrane transporter activity Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. go.json uracil/uridine permease activity http://purl.obolibrary.org/obo/GO_0015213 GO:0015214 biolink:MolecularActivity pyrimidine nucleoside transmembrane transporter activity Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015214 GO:0015215 biolink:MolecularActivity nucleotide transmembrane transporter activity Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015215 GO:0030850 biolink:BiologicalProcess prostate gland development The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. go.json prostate development http://purl.obolibrary.org/obo/GO_0030850 GO:0015210 biolink:MolecularActivity uracil transmembrane transporter activity Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. go.json uracil/uridine permease activity http://purl.obolibrary.org/obo/GO_0015210 GO:0015211 biolink:MolecularActivity purine nucleoside transmembrane transporter activity Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015211 GO:0030846 biolink:BiologicalProcess termination of RNA polymerase II transcription, poly(A)-coupled An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination. go.json termination of RNA polymerase II transcription, polyadenylation-coupled|transcription termination from Pol II promoter, RNA polymerase(A) coupled|transcription termination from Pol II promoter, poly(A) coupled http://purl.obolibrary.org/obo/GO_0030846 GO:0030847 biolink:BiologicalProcess termination of RNA polymerase II transcription, exosome-dependent The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end. go.json termination of RNA polymerase II transcription, poly(A)-independent|transcription termination from Pol II promoter, RNA polymerase(A)-independent|transcription termination from Pol II promoter, poly(A)-independent http://purl.obolibrary.org/obo/GO_0030847 GO:0030844 biolink:BiologicalProcess positive regulation of intermediate filament depolymerization Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization. go.json activation of intermediate filament depolymerization|positive regulation of intermediate filament polymerization and/or depolymerization|stimulation of intermediate filament depolymerization|up regulation of intermediate filament depolymerization|up-regulation of intermediate filament depolymerization|upregulation of intermediate filament depolymerization http://purl.obolibrary.org/obo/GO_0030844 GO:0030845 biolink:BiologicalProcess phospholipase C-inhibiting G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG). go.json G-protein-coupled inhibitory pathway of phospholipase C|GPCR signaling pathway coupled to inhibition of phospholipase C activity|GPCR signaling pathway via inhibition of PLC|PLC-inhibiting GPCR signaling pathway|inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway|phospholipase C inhibition|phospholipase C-inhibiting G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030845 GO:0030842 biolink:BiologicalProcess regulation of intermediate filament depolymerization Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament. go.json http://purl.obolibrary.org/obo/GO_0030842 GO:0030843 biolink:BiologicalProcess negative regulation of intermediate filament depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization. go.json down regulation of intermediate filament depolymerization|down-regulation of intermediate filament depolymerization|downregulation of intermediate filament depolymerization|inhibition of intermediate filament depolymerization|negative regulation of intermediate filament polymerization and/or depolymerization http://purl.obolibrary.org/obo/GO_0030843 GO:0030840 biolink:BiologicalProcess negative regulation of intermediate filament polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization. go.json down regulation of intermediate filament polymerization|down-regulation of intermediate filament polymerization|downregulation of intermediate filament polymerization|inhibition of intermediate filament polymerization|negative regulation of intermediate filament polymerization and/or depolymerization http://purl.obolibrary.org/obo/GO_0030840 GO:0030841 biolink:BiologicalProcess positive regulation of intermediate filament polymerization Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization. go.json activation of intermediate filament polymerization|positive regulation of intermediate filament polymerization and/or depolymerization|stimulation of intermediate filament polymerization|up regulation of intermediate filament polymerization|up-regulation of intermediate filament polymerization|upregulation of intermediate filament polymerization http://purl.obolibrary.org/obo/GO_0030841 GO:0030848 biolink:MolecularActivity threo-3-hydroxyaspartate ammonia-lyase activity Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate. EC:4.3.1.16|KEGG_REACTION:R05758|MetaCyc:4.3.1.16-RXN|RHEA:12424 go.json 3-hydroxyaspartate dehydratase activity|L-threo-3-hydroxyaspartate dehydratase activity|threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)|threo-3-hydroxy-L-aspartate ammonia-lyase activity|threo-3-hydroxyaspartate dehydratase activity http://purl.obolibrary.org/obo/GO_0030848 GO:0030849 biolink:CellularComponent autosome Any chromosome other than a sex chromosome. Wikipedia:Autosome go.json http://purl.obolibrary.org/obo/GO_0030849 GO:0015227 biolink:MolecularActivity acyl carnitine transmembrane transporter activity Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. Reactome:R-HSA-200424 go.json acylcarnitine transporter activity http://purl.obolibrary.org/obo/GO_0015227 GO:0015228 biolink:MolecularActivity coenzyme A transmembrane transporter activity Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. Reactome:R-HSA-199216|Reactome:R-HSA-9837333 go.json coenzyme A transporter activity http://purl.obolibrary.org/obo/GO_0015228 GO:0015229 biolink:MolecularActivity L-ascorbic acid transmembrane transporter activity Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. Reactome:R-HSA-198870 go.json L-ascorbate transporter activity|vitamin C transporter activity http://purl.obolibrary.org/obo/GO_0015229 GO:0015223 biolink:MolecularActivity obsolete vitamin or cofactor transporter activity OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells. go.json vitamin or cofactor transporter activity|vitamin/cofactor transporter activity True http://purl.obolibrary.org/obo/GO_0015223 GO:0015224 biolink:MolecularActivity biopterin transmembrane transporter activity Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. go.json biopterin transporter activity http://purl.obolibrary.org/obo/GO_0015224 GO:0015225 biolink:MolecularActivity biotin transmembrane transporter activity Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. RHEA:28458 go.json biotin transporter activity|vitamin B7 transporter activity|vitamin H transporter activity http://purl.obolibrary.org/obo/GO_0015225 GO:0015226 biolink:MolecularActivity carnitine transmembrane transporter activity Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. Reactome:R-HSA-164967|Reactome:R-HSA-165026|Reactome:R-HSA-549297|Reactome:R-HSA-5625674 go.json vitamin Bt transporter activity http://purl.obolibrary.org/obo/GO_0015226 GO:0015220 biolink:MolecularActivity choline transmembrane transporter activity Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. Reactome:R-HSA-429594|Reactome:R-HSA-444433|Reactome:R-HSA-5658483|Reactome:R-HSA-6797956 go.json amino acid/choline transmembrane transporter activity|choline permease activity http://purl.obolibrary.org/obo/GO_0015220 GO:0015221 biolink:MolecularActivity lipopolysaccharide transmembrane transporter activity Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. go.json LPS transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015221 GO:0015222 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015222 GO:0030835 biolink:BiologicalProcess negative regulation of actin filament depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. go.json actin filament stabilization|down regulation of actin filament depolymerization|down-regulation of actin filament depolymerization|downregulation of actin filament depolymerization|inhibition of actin filament depolymerization|negative regulation of actin depolymerization|negative regulation of actin polymerization and/or depolymerization http://purl.obolibrary.org/obo/GO_0030835 GO:0005879 biolink:CellularComponent axonemal microtubule A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. go.json http://purl.obolibrary.org/obo/GO_0005879 GO:0030836 biolink:BiologicalProcess positive regulation of actin filament depolymerization Any process that activates or increases the frequency, rate or extent of actin depolymerization. go.json actin filament destabilization|activation of actin filament depolymerization|positive regulation of actin depolymerization|positive regulation of actin polymerization and/or depolymerization|stimulation of actin filament depolymerization|up regulation of actin filament depolymerization|up-regulation of actin filament depolymerization|upregulation of actin filament depolymerization http://purl.obolibrary.org/obo/GO_0030836 GO:0030833 biolink:BiologicalProcess regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. go.json regulation of actin polymerization http://purl.obolibrary.org/obo/GO_0030833 GO:0030834 biolink:BiologicalProcess regulation of actin filament depolymerization Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. go.json regulation of actin depolymerization http://purl.obolibrary.org/obo/GO_0030834 GO:0030831 biolink:BiologicalProcess obsolete positive regulation of cGMP catabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP. go.json activation of cGMP catabolic process|positive regulation of cGMP breakdown|positive regulation of cGMP catabolism|positive regulation of cGMP degradation|stimulation of cGMP catabolic process|up regulation of cGMP catabolic process|up-regulation of cGMP catabolic process|upregulation of cGMP catabolic process True http://purl.obolibrary.org/obo/GO_0030831 GO:0005875 biolink:CellularComponent microtubule associated complex Any multimeric complex connected to a microtubule. go.json http://purl.obolibrary.org/obo/GO_0005875 GO:0005876 biolink:CellularComponent spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. go.json http://purl.obolibrary.org/obo/GO_0005876 GO:0030832 biolink:BiologicalProcess regulation of actin filament length Any process that controls the length of actin filaments in a cell. go.json http://purl.obolibrary.org/obo/GO_0030832 GO:0005873 biolink:CellularComponent plus-end kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0005873 GO:0005874 biolink:CellularComponent microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. NIF_Subcellular:sao1846835077|Wikipedia:Microtubule go.json microtubuli|microtubulus|neurotubule http://purl.obolibrary.org/obo/GO_0005874 goslim_metagenomics GO:0030830 biolink:BiologicalProcess obsolete negative regulation of cGMP catabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP. go.json down regulation of cGMP catabolic process|down-regulation of cGMP catabolic process|downregulation of cGMP catabolic process|inhibition of cGMP catabolic process|negative regulation of cGMP breakdown|negative regulation of cGMP catabolism|negative regulation of cGMP degradation True http://purl.obolibrary.org/obo/GO_0030830 GO:0005871 biolink:CellularComponent kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. go.json http://purl.obolibrary.org/obo/GO_0005871 GO:0005872 biolink:CellularComponent minus-end kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule. go.json http://purl.obolibrary.org/obo/GO_0005872 GO:0005870 biolink:CellularComponent actin capping protein of dynactin complex A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex. go.json http://purl.obolibrary.org/obo/GO_0005870 GO:0030839 biolink:BiologicalProcess regulation of intermediate filament polymerization Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament. go.json http://purl.obolibrary.org/obo/GO_0030839 GO:0030837 biolink:BiologicalProcess negative regulation of actin filament polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. go.json down regulation of actin filament polymerization|down-regulation of actin filament polymerization|downregulation of actin filament polymerization|inhibition of actin filament polymerization|negative regulation of actin polymerization|negative regulation of actin polymerization and/or depolymerization http://purl.obolibrary.org/obo/GO_0030837 GO:0030838 biolink:BiologicalProcess positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization. go.json activation of actin filament polymerization|positive regulation of actin polymerization|positive regulation of actin polymerization and/or depolymerization|stimulation of actin filament polymerization|up regulation of actin filament polymerization|up-regulation of actin filament polymerization|upregulation of actin filament polymerization http://purl.obolibrary.org/obo/GO_0030838 GO:0030824 biolink:BiologicalProcess obsolete negative regulation of cGMP metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP. go.json down regulation of cGMP metabolic process|down-regulation of cGMP metabolic process|downregulation of cGMP metabolic process|inhibition of cGMP metabolic process|negative regulation of cGMP metabolism True http://purl.obolibrary.org/obo/GO_0030824 GO:0030825 biolink:BiologicalProcess obsolete positive regulation of cGMP metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP. go.json activation of cGMP metabolic process|positive regulation of cGMP metabolism|stimulation of cGMP metabolic process|up regulation of cGMP metabolic process|up-regulation of cGMP metabolic process|upregulation of cGMP metabolic process True http://purl.obolibrary.org/obo/GO_0030825 GO:0030822 biolink:BiologicalProcess obsolete positive regulation of cAMP catabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json activation of cAMP catabolic process|positive regulation of 3',5' cAMP catabolic process|positive regulation of 3',5' cAMP catabolism|positive regulation of 3',5'-cAMP catabolic process|positive regulation of 3',5'-cAMP catabolism|positive regulation of adenosine 3',5'-cyclophosphate catabolic process|positive regulation of adenosine 3',5'-cyclophosphate catabolism|positive regulation of cAMP breakdown|positive regulation of cAMP catabolism|positive regulation of cAMP degradation|positive regulation of cyclic AMP catabolic process|positive regulation of cyclic AMP catabolism|stimulation of cAMP catabolic process|up regulation of cAMP catabolic process|up-regulation of cAMP catabolic process|upregulation of cAMP catabolic process True http://purl.obolibrary.org/obo/GO_0030822 GO:0005888 biolink:CellularComponent obsolete proteoglycan integral to plasma membrane OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer. go.json proteoglycan integral to plasma membrane True http://purl.obolibrary.org/obo/GO_0005888 GO:0005889 biolink:CellularComponent potassium:proton exchanging ATPase complex A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present. go.json hydrogen/potassium-exchanging ATPase complex|hydrogen:potassium-exchanging ATPase complex|proton pump http://purl.obolibrary.org/obo/GO_0005889 GO:0030823 biolink:BiologicalProcess obsolete regulation of cGMP metabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. go.json regulation of cGMP metabolism True http://purl.obolibrary.org/obo/GO_0030823 GO:0005886 biolink:CellularComponent plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. NIF_Subcellular:sao1663586795|Wikipedia:Cell_membrane go.json bacterial inner membrane|cell membrane|cellular membrane|cytoplasmic membrane|inner endospore membrane|integral component of plasma membrane|integral to plasma membrane|juxtamembrane|plasma membrane lipid bilayer|plasmalemma http://purl.obolibrary.org/obo/GO_0005886 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_plant|goslim_yeast|prokaryote_subset GO:0030820 biolink:BiologicalProcess obsolete regulation of cAMP catabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json regulation of 3',5' cAMP catabolic process|regulation of 3',5' cAMP catabolism|regulation of 3',5'-cAMP catabolic process|regulation of 3',5'-cAMP catabolism|regulation of adenosine 3',5'-cyclophosphate catabolic process|regulation of adenosine 3',5'-cyclophosphate catabolism|regulation of cAMP breakdown|regulation of cAMP catabolism|regulation of cAMP degradation|regulation of cyclic AMP catabolic process|regulation of cyclic AMP catabolism True http://purl.obolibrary.org/obo/GO_0030820 GO:0030821 biolink:BiologicalProcess obsolete negative regulation of cAMP catabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). go.json down regulation of cAMP catabolic process|down-regulation of cAMP catabolic process|downregulation of cAMP catabolic process|inhibition of cAMP catabolic process|negative regulation of 3',5' cAMP catabolic process|negative regulation of 3',5' cAMP catabolism|negative regulation of 3',5'-cAMP catabolic process|negative regulation of 3',5'-cAMP catabolism|negative regulation of adenosine 3',5'-cyclophosphate catabolic process|negative regulation of adenosine 3',5'-cyclophosphate catabolism|negative regulation of cAMP breakdown|negative regulation of cAMP catabolism|negative regulation of cAMP degradation|negative regulation of cyclic AMP catabolic process|negative regulation of cyclic AMP catabolism True http://purl.obolibrary.org/obo/GO_0030821 GO:0005887 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005887 GO:0005884 biolink:CellularComponent actin filament A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. FMA:63850|NIF_Subcellular:sao1588493326|Wikipedia:Actin go.json microfilament http://purl.obolibrary.org/obo/GO_0005884 GO:0005885 biolink:CellularComponent Arp2/3 protein complex A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. go.json http://purl.obolibrary.org/obo/GO_0005885 GO:0005882 biolink:CellularComponent intermediate filament A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. FMA:63851|NIF_Subcellular:sao952483289|Wikipedia:Intermediate_filament go.json intermediate filament associated protein|type I intermediate filament associated protein|type II intermediate filament associated protein http://purl.obolibrary.org/obo/GO_0005882 GO:0005883 biolink:CellularComponent neurofilament A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. NIF_Subcellular:sao1316272517|Wikipedia:Neurofilament go.json type IV intermediate filament http://purl.obolibrary.org/obo/GO_0005883 GO:0005880 biolink:CellularComponent nuclear microtubule Any microtubule in the nucleus of a cell. go.json http://purl.obolibrary.org/obo/GO_0005880 GO:0005881 biolink:CellularComponent cytoplasmic microtubule Any microtubule in the cytoplasm of a cell. go.json non-spindle-associated astral microtubule http://purl.obolibrary.org/obo/GO_0005881 GO:0030828 biolink:BiologicalProcess obsolete positive regulation of cGMP biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. go.json activation of cGMP biosynthetic process|positive regulation of cGMP anabolism|positive regulation of cGMP biosynthesis|positive regulation of cGMP formation|positive regulation of cGMP synthesis|stimulation of cGMP biosynthetic process|up regulation of cGMP biosynthetic process|up-regulation of cGMP biosynthetic process|upregulation of cGMP biosynthetic process True http://purl.obolibrary.org/obo/GO_0030828 GO:0015209 biolink:MolecularActivity cytosine transmembrane transporter activity Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015209 GO:0030829 biolink:BiologicalProcess obsolete regulation of cGMP catabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP. go.json regulation of cGMP breakdown|regulation of cGMP catabolism|regulation of cGMP degradation True http://purl.obolibrary.org/obo/GO_0030829 GO:0030826 biolink:BiologicalProcess obsolete regulation of cGMP biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. go.json regulation of cGMP anabolism|regulation of cGMP biosynthesis|regulation of cGMP formation|regulation of cGMP synthesis True http://purl.obolibrary.org/obo/GO_0030826 GO:0030827 biolink:BiologicalProcess obsolete negative regulation of cGMP biosynthetic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. go.json down regulation of cGMP biosynthetic process|down-regulation of cGMP biosynthetic process|downregulation of cGMP biosynthetic process|inhibition of cGMP biosynthetic process|negative regulation of cGMP anabolism|negative regulation of cGMP biosynthesis|negative regulation of cGMP formation|negative regulation of cGMP synthesis True http://purl.obolibrary.org/obo/GO_0030827 GO:0015205 biolink:MolecularActivity nucleobase transmembrane transporter activity Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015205 GO:0015206 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015206 GO:0015207 biolink:MolecularActivity adenine transmembrane transporter activity Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. RHEA:34999|Reactome:R-HSA-163215|Reactome:R-HSA-5672027 go.json http://purl.obolibrary.org/obo/GO_0015207 GO:0015208 biolink:MolecularActivity guanine transmembrane transporter activity Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015208 GO:0015201 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015201 GO:0015202 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015202 GO:0015203 biolink:MolecularActivity polyamine transmembrane transporter activity Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other. go.json amine/amide/polyamine channel activity http://purl.obolibrary.org/obo/GO_0015203 GO:0015204 biolink:MolecularActivity urea transmembrane transporter activity Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2. RHEA:32799|Reactome:R-HSA-444126 go.json urea transporter activity http://purl.obolibrary.org/obo/GO_0015204 GO:0015200 biolink:MolecularActivity methylammonium transmembrane transporter activity Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015200 GO:0015399 biolink:MolecularActivity primary active transmembrane transporter activity Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy. EC:7.-.-.-|TC:3 go.json primary active transporter http://purl.obolibrary.org/obo/GO_0015399 GO:0015395 biolink:MolecularActivity nucleoside transmembrane transporter activity, down a concentration gradient Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient. go.json equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity|equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity|equilibrative nucleoside transporter activity http://purl.obolibrary.org/obo/GO_0015395 GO:0015396 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015396 GO:0015397 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015397 GO:0015398 biolink:MolecularActivity high-affinity secondary active ammonium transmembrane transporter activity Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity secondary active ammonium transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015398 GO:0015391 biolink:MolecularActivity nucleobase:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in). go.json nucleobase:cation symporter activity http://purl.obolibrary.org/obo/GO_0015391 GO:0015392 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015392 GO:0015393 biolink:MolecularActivity obsolete uracil/uridine permease activity OBSOLETE. (Was not defined before being made obsolete). go.json uracil/uridine permease activity True http://purl.obolibrary.org/obo/GO_0015393 GO:0015394 biolink:MolecularActivity uridine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in). go.json nucleoside (uridine) permease activity|uridine:hydrogen ion symporter activity http://purl.obolibrary.org/obo/GO_0015394 GO:0005978 biolink:BiologicalProcess glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. MetaCyc:GLYCOGENSYNTH-PWY go.json glycogen anabolism|glycogen biosynthesis|glycogen formation|glycogen synthesis http://purl.obolibrary.org/obo/GO_0005978 GO:0030934 biolink:CellularComponent anchoring collagen complex Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures. go.json connecting collagen|linking collagen http://purl.obolibrary.org/obo/GO_0030934 GO:0005979 biolink:BiologicalProcess regulation of glycogen biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. go.json regulation of glycogen anabolism|regulation of glycogen biosynthesis|regulation of glycogen formation|regulation of glycogen synthesis http://purl.obolibrary.org/obo/GO_0005979 GO:0030935 biolink:CellularComponent sheet-forming collagen trimer A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet. go.json hexagonal network-forming collagen http://purl.obolibrary.org/obo/GO_0030935 GO:0005976 biolink:BiologicalProcess polysaccharide metabolic process The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json glycan metabolic process|glycan metabolism|multicellular organismal polysaccharide metabolic process|polysaccharide metabolism http://purl.obolibrary.org/obo/GO_0005976 goslim_pir GO:0030932 biolink:CellularComponent amyloplast ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in the amyloplast. go.json http://purl.obolibrary.org/obo/GO_0030932 GO:0030933 biolink:CellularComponent chloroplast ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in the chloroplast. go.json http://purl.obolibrary.org/obo/GO_0030933 GO:0005977 biolink:BiologicalProcess glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. go.json glycogen metabolism http://purl.obolibrary.org/obo/GO_0005977 GO:0030930 biolink:CellularComponent homotetrameric ADPG pyrophosphorylase complex A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species. go.json http://purl.obolibrary.org/obo/GO_0030930 GO:0005974 biolink:CellularComponent obsolete fibrinogen gamma chain OBSOLETE. (Was not defined before being made obsolete). go.json fibrinogen gamma chain True http://purl.obolibrary.org/obo/GO_0005974 GO:0030931 biolink:CellularComponent heterotetrameric ADPG pyrophosphorylase complex A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0030931 GO:0005975 biolink:BiologicalProcess carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Wikipedia:Carbohydrate_metabolism go.json carbohydrate metabolism http://purl.obolibrary.org/obo/GO_0005975 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant|goslim_pombe|goslim_yeast|prokaryote_subset GO:0005972 biolink:CellularComponent obsolete fibrinogen alpha chain OBSOLETE. (Was not defined before being made obsolete). go.json fibrinogen alpha chain True http://purl.obolibrary.org/obo/GO_0005972 GO:0005973 biolink:CellularComponent obsolete fibrinogen beta chain OBSOLETE. (Was not defined before being made obsolete). go.json fibrinogen beta chain True http://purl.obolibrary.org/obo/GO_0005973 GO:0005970 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005970 GO:0005971 biolink:CellularComponent ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. go.json RNR complex|ribonucleotide reductase complex http://purl.obolibrary.org/obo/GO_0005971 GO:0030938 biolink:CellularComponent collagen type XVIII trimer A collagen homotrimer of alpha1(XVIII) chains. go.json http://purl.obolibrary.org/obo/GO_0030938 GO:0030939 biolink:BiologicalProcess obsolete response to long-day photoperiod OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark. go.json response to long-day photoperiod True http://purl.obolibrary.org/obo/GO_0030939 GO:0030936 biolink:CellularComponent transmembrane collagen trimer Any collagen trimer that passes through a lipid bilayer membrane. go.json MACIT http://purl.obolibrary.org/obo/GO_0030936 GO:0030937 biolink:CellularComponent collagen type XVII trimer A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin. go.json http://purl.obolibrary.org/obo/GO_0030937 GO:0005989 biolink:BiologicalProcess lactose biosynthetic process The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose. go.json lactose anabolism|lactose biosynthesis|lactose formation|lactose synthesis http://purl.obolibrary.org/obo/GO_0005989 GO:0030923 biolink:BiologicalProcess obsolete metal incorporation into metallo-oxygen cluster OBSOLETE. The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate. go.json True http://purl.obolibrary.org/obo/GO_0030923 GO:0030924 biolink:BiologicalProcess obsolete manganese incorporation into metallo-oxygen cluster OBSOLETE. The incorporation of manganese into a metallo-oxygen cluster. go.json True http://purl.obolibrary.org/obo/GO_0030924 GO:0030921 biolink:BiologicalProcess peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. RESID:AA0183 go.json http://purl.obolibrary.org/obo/GO_0030921 gocheck_do_not_annotate GO:0005987 biolink:BiologicalProcess sucrose catabolic process The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside. go.json sucrose breakdown|sucrose catabolism|sucrose degradation http://purl.obolibrary.org/obo/GO_0005987 GO:0030922 biolink:BiologicalProcess peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. RESID:AA0365 go.json http://purl.obolibrary.org/obo/GO_0030922 gocheck_do_not_annotate GO:0005988 biolink:BiologicalProcess lactose metabolic process The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose. go.json lactose metabolism http://purl.obolibrary.org/obo/GO_0005988 GO:0005985 biolink:BiologicalProcess sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. go.json sucrose metabolism http://purl.obolibrary.org/obo/GO_0005985 GO:0005986 biolink:BiologicalProcess sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. MetaCyc:SUCSYN-PWY go.json sucrose anabolism|sucrose biosynthesis|sucrose formation|sucrose synthesis http://purl.obolibrary.org/obo/GO_0005986 GO:0030920 biolink:BiologicalProcess peptidyl-serine acetylation The acetylation of peptidyl-serine. go.json http://purl.obolibrary.org/obo/GO_0030920 gocheck_do_not_annotate GO:0005983 biolink:BiologicalProcess starch catabolic process The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants. MetaCyc:PWY-842 go.json starch breakdown|starch catabolism|starch degradation http://purl.obolibrary.org/obo/GO_0005983 GO:0005984 biolink:BiologicalProcess disaccharide metabolic process The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units. go.json disaccharide metabolism http://purl.obolibrary.org/obo/GO_0005984 GO:0005981 biolink:BiologicalProcess regulation of glycogen catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. go.json regulation of glycogen breakdown|regulation of glycogen catabolism|regulation of glycogen degradation|regulation of glycogenolysis http://purl.obolibrary.org/obo/GO_0005981 GO:0005982 biolink:BiologicalProcess starch metabolic process The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose. go.json starch metabolism http://purl.obolibrary.org/obo/GO_0005982 GO:0030929 biolink:CellularComponent ADPG pyrophosphorylase complex Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits. go.json http://purl.obolibrary.org/obo/GO_0030929 goslim_pir GO:0005980 biolink:BiologicalProcess glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. MetaCyc:GLYCOCAT-PWY go.json glycogen breakdown|glycogen catabolism|glycogen degradation|glycogenolysis http://purl.obolibrary.org/obo/GO_0005980 GO:0030927 biolink:BiologicalProcess obsolete manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide OBSOLETE. The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. RESID:AA0366 go.json True http://purl.obolibrary.org/obo/GO_0030927 GO:0015308 biolink:MolecularActivity obsolete amiloride:proton antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out). go.json amiloride:hydrogen antiporter activity True http://purl.obolibrary.org/obo/GO_0015308 GO:0030928 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030928 GO:0015309 biolink:MolecularActivity cycloheximide:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out). go.json cycloheximide:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015309 GO:0030925 biolink:BiologicalProcess obsolete calcium incorporation into metallo-oxygen cluster OBSOLETE. The incorporation of calcium into a metallo-oxygen cluster. go.json True http://purl.obolibrary.org/obo/GO_0030925 GO:0030926 biolink:BiologicalProcess obsolete calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide OBSOLETE. The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. RESID:AA0366 go.json True http://purl.obolibrary.org/obo/GO_0030926 GO:0015304 biolink:MolecularActivity glucose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in). go.json galactose, glucose uniporter activity http://purl.obolibrary.org/obo/GO_0015304 GO:0015305 biolink:MolecularActivity obsolete lactose, galactose:proton symporter activity OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in). go.json lactose, galactose:hydrogen symporter activity|lactose, galactose:proton symporter activity|lactose,galactose:proton symporter activity True http://purl.obolibrary.org/obo/GO_0015305 GO:0015306 biolink:MolecularActivity sialate:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in). go.json cation/sialate symporter activity|cation:sialate symporter activity|sialate transporter activity|sialate/cation symporter activity|sialate:cation symporter activity http://purl.obolibrary.org/obo/GO_0015306 GO:0015307 biolink:MolecularActivity obsolete drug:proton antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out). go.json carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity|drug:hydrogen antiporter activity True http://purl.obolibrary.org/obo/GO_0015307 GO:0015300 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015300 GO:0015301 biolink:MolecularActivity obsolete anion:anion antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). go.json anion exchanger activity|bicarbonate:chloride antiporter True http://purl.obolibrary.org/obo/GO_0015301 GO:0015302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015302 GO:0015303 biolink:MolecularActivity obsolete galactose, glucose uniporter activity OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in). go.json galactose, glucose uniporter activity True http://purl.obolibrary.org/obo/GO_0015303 GO:0030912 biolink:BiologicalProcess response to deep water Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle. go.json http://purl.obolibrary.org/obo/GO_0030912 GO:0005956 biolink:CellularComponent protein kinase CK2 complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. go.json casein kinase II complex http://purl.obolibrary.org/obo/GO_0005956 GO:0005957 biolink:CellularComponent obsolete debranching enzyme OBSOLETE. (Was not defined before being made obsolete). go.json debranching enzyme True http://purl.obolibrary.org/obo/GO_0005957 GO:0030913 biolink:BiologicalProcess paranodal junction assembly Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. go.json paranodal axoglial junction formation|paranodal junction biosynthesis|paranodal junction formation http://purl.obolibrary.org/obo/GO_0030913 GO:0005954 biolink:CellularComponent calcium- and calmodulin-dependent protein kinase complex An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. go.json CAMK2|CaMKII|calcium/calmodulin-dependent protein kinase complex http://purl.obolibrary.org/obo/GO_0005954 GO:0030910 biolink:BiologicalProcess olfactory placode formation The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. go.json http://purl.obolibrary.org/obo/GO_0030910 GO:0030911 biolink:MolecularActivity TPR domain binding Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. go.json tetratricopeptide repeat domain binding http://purl.obolibrary.org/obo/GO_0030911 GO:0005955 biolink:CellularComponent calcineurin complex A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. go.json calcium-dependent protein serine/threonine phosphatase complex|protein phosphatase type 2B complex http://purl.obolibrary.org/obo/GO_0005955 GO:0005952 biolink:CellularComponent cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. go.json 3',5' cAMP-dependent protein kinase complex|3',5'-cAMP-dependent protein kinase complex|PKA|adenosine 3',5'-cyclophosphate-dependent protein kinase complex|cyclic AMP-dependent protein kinase complex http://purl.obolibrary.org/obo/GO_0005952 GO:0005953 biolink:CellularComponent CAAX-protein geranylgeranyltransferase complex A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. go.json http://purl.obolibrary.org/obo/GO_0005953 GO:0005950 biolink:CellularComponent anthranilate synthase complex A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine. MetaCyc:ANTHRANSYN-CPLX go.json http://purl.obolibrary.org/obo/GO_0005950 GO:0005951 biolink:CellularComponent carbamoyl-phosphate synthase complex A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events. go.json arginine-specific carbamoyl phosphate synthetase complex|carbamoyl phosphate synthase complex|carbamoyl-phosphate synthase arginine-specific complex http://purl.obolibrary.org/obo/GO_0005951 GO:0030918 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030918 GO:0030919 biolink:BiologicalProcess peptidyl-serine O-acetylation The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine. RESID:AA0364 go.json http://purl.obolibrary.org/obo/GO_0030919 gocheck_do_not_annotate GO:0030916 biolink:BiologicalProcess otic vesicle formation The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. go.json otocyst biosynthesis|otocyst formation http://purl.obolibrary.org/obo/GO_0030916 GO:0030917 biolink:BiologicalProcess midbrain-hindbrain boundary development The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. go.json MHB development|isthmic organizer development|isthmomesencephalic boundary development|isthmus development|midbrain-hindbrain orgainizer development http://purl.obolibrary.org/obo/GO_0030917 GO:0030914 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030914 GO:0030915 biolink:CellularComponent Smc5-Smc6 complex A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. go.json http://purl.obolibrary.org/obo/GO_0030915 GO:0005958 biolink:CellularComponent DNA-dependent protein kinase-DNA ligase 4 complex A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. go.json http://purl.obolibrary.org/obo/GO_0005958 GO:0005959 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005959 GO:0030901 biolink:BiologicalProcess midbrain development The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). go.json mesencephalon development http://purl.obolibrary.org/obo/GO_0030901 GO:0005967 biolink:CellularComponent mitochondrial pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. go.json pyruvate dehydrogenase complex (lipoamide) http://purl.obolibrary.org/obo/GO_0005967 GO:0030902 biolink:BiologicalProcess hindbrain development The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). go.json rhombencephalon development http://purl.obolibrary.org/obo/GO_0030902 GO:0005968 biolink:CellularComponent Rab-protein geranylgeranyltransferase complex An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein). go.json GGTase-II complex|Rab geranylgeranyltransferase complex|RabGGTase complex http://purl.obolibrary.org/obo/GO_0005968 GO:0005965 biolink:CellularComponent protein farnesyltransferase complex A protein complex that possesses protein farnesyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0005965 GO:0005966 biolink:CellularComponent obsolete cyclic-nucleotide phosphodiesterase complex OBSOLETE. An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide. go.json photoreceptor cyclic-nucleotide phosphodiesterase complex True http://purl.obolibrary.org/obo/GO_0005966 GO:0030900 biolink:BiologicalProcess forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). go.json prosencephalon development http://purl.obolibrary.org/obo/GO_0030900 GO:0005963 biolink:CellularComponent magnesium-dependent protein serine/threonine phosphatase complex An intracellular enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase. go.json http://purl.obolibrary.org/obo/GO_0005963 GO:0005964 biolink:CellularComponent phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. go.json http://purl.obolibrary.org/obo/GO_0005964 GO:0005961 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005961 GO:0005962 biolink:CellularComponent mitochondrial isocitrate dehydrogenase complex (NAD+) Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity. go.json http://purl.obolibrary.org/obo/GO_0005962 GO:0030909 biolink:BiologicalProcess non-intein-mediated protein splicing The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins. go.json http://purl.obolibrary.org/obo/GO_0030909 GO:0005960 biolink:CellularComponent glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. Wikipedia:Glycine_decarboxylase_complex go.json glycine cleavage system|glycine decarboxylase complex|glycine dehydrogenase (decarboxylating) complex|glycine dehydrogenase complex (decarboxylating)|glycine synthase complex http://purl.obolibrary.org/obo/GO_0005960 goslim_pir GO:0030907 biolink:CellularComponent MBF transcription complex A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p. go.json DSC1 transcription factor complex|MBF|Mlu1-box binding factor http://purl.obolibrary.org/obo/GO_0030907 GO:0030908 biolink:BiologicalProcess protein splicing The post-translational removal of peptide sequences from within a protein sequence. Wikipedia:Protein_splicing go.json http://purl.obolibrary.org/obo/GO_0030908 GO:0030905 biolink:CellularComponent retromer, tubulation complex The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodeling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6. go.json SNX-BAR dimer|heterodimeric membrane-deforming retromer subcomplex|retromer complex, outer shell http://purl.obolibrary.org/obo/GO_0030905 GO:0030906 biolink:CellularComponent retromer, cargo-selective complex The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals. go.json cargo-selective retromer subcomplex|retromer CSC|retromer complex, inner shell|retromer, CRC|retromer, cargo recognition complex http://purl.obolibrary.org/obo/GO_0030906 GO:0030903 biolink:BiologicalProcess notochord development The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. go.json http://purl.obolibrary.org/obo/GO_0030903 GO:0030904 biolink:CellularComponent retromer complex A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. go.json http://purl.obolibrary.org/obo/GO_0030904 goslim_pir GO:0005969 biolink:CellularComponent serine-pyruvate aminotransferase complex An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate. go.json serine-pyruvate aminotransferase, type 1 complex|serine-pyruvate aminotransferase, type 2B complex http://purl.obolibrary.org/obo/GO_0005969 GO:0005934 biolink:CellularComponent cellular bud tip The end of a cellular bud distal to the site of attachment to the mother cell. go.json http://purl.obolibrary.org/obo/GO_0005934 GO:0005935 biolink:CellularComponent cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. go.json http://purl.obolibrary.org/obo/GO_0005935 GO:0005932 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005932 GO:0005933 biolink:CellularComponent cellular bud A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated. go.json http://purl.obolibrary.org/obo/GO_0005933 goslim_candida|goslim_pir|goslim_yeast GO:0005930 biolink:CellularComponent axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. Wikipedia:Axoneme go.json ciliary axoneme|cilium axoneme|flagellar axoneme|flagellum axoneme http://purl.obolibrary.org/obo/GO_0005930 goslim_pir GO:0005931 biolink:CellularComponent axonemal nexin link A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules. go.json axonemal interdoublet link|nexin complex http://purl.obolibrary.org/obo/GO_0005931 GO:0005938 biolink:CellularComponent cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. Wikipedia:Cell_cortex go.json cell periphery|peripheral cytoplasm http://purl.obolibrary.org/obo/GO_0005938 goslim_candida|goslim_yeast GO:0005936 biolink:CellularComponent obsolete shmoo OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles. go.json shmoo True http://purl.obolibrary.org/obo/GO_0005936 GO:0005937 biolink:CellularComponent mating projection The projection formed by unicellular fungi in response to mating pheromone. go.json conjugation tube|shmoo http://purl.obolibrary.org/obo/GO_0005937 goslim_pir GO:0005945 biolink:CellularComponent 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. go.json http://purl.obolibrary.org/obo/GO_0005945 GO:0005946 biolink:CellularComponent alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present. go.json UDP-glucose-glucosephosphate glucosyltransferase complex|trehalose-6-phosphate synthase complex|trehalose-6-phosphate synthase/phosphatase http://purl.obolibrary.org/obo/GO_0005946 GO:0005943 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class IA A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. go.json 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex|1-phosphatidylinositol-4-phosphate kinase, class IA complex|class IA PI3K complex|phosphoinositide 3-kinase complex, class IA http://purl.obolibrary.org/obo/GO_0005943 GO:0005944 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class IB A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks. go.json 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex|1-phosphatidylinositol-4-phosphate kinase, class IB complex|class IB PI3K complex|phosphoinositide 3-kinase complex, class IB http://purl.obolibrary.org/obo/GO_0005944 GO:0005941 biolink:CellularComponent obsolete unlocalized protein complex OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products. go.json unlocalized protein complex True http://purl.obolibrary.org/obo/GO_0005941 GO:0005942 biolink:CellularComponent phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. go.json 1-phosphatidylinositol 3-kinase complex|PI3-kinase p85-subunit alpha- PI3-kinase p110 complex|PI3K complex|PIK3C3-PIK3R4 complex|PIK3CA-PIK3R1 complex|phosphoinositide 3-kinase complex http://purl.obolibrary.org/obo/GO_0005942 goslim_pir GO:0005940 biolink:CellularComponent septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. Wikipedia:Septin_ring go.json http://purl.obolibrary.org/obo/GO_0005940 GO:0005949 biolink:CellularComponent obsolete aminoadipate-semialdehyde dehydrogenase complex OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde. go.json aminoadipate-semialdehyde dehydrogenase complex True http://purl.obolibrary.org/obo/GO_0005949 GO:0005947 biolink:CellularComponent mitochondrial alpha-ketoglutarate dehydrogenase complex Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity. go.json 2-oxoglutarate dehydrogenase complex http://purl.obolibrary.org/obo/GO_0005947 GO:0005948 biolink:CellularComponent acetolactate synthase complex A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. go.json acetohydroxyacid synthase complex http://purl.obolibrary.org/obo/GO_0005948 GO:0005912 biolink:CellularComponent adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. Wikipedia:Adherens_junction go.json cell-cell adherens junction http://purl.obolibrary.org/obo/GO_0005912 GO:0005913 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005913 GO:0005911 biolink:CellularComponent cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. NIF_Subcellular:sao1922892319 go.json cell-cell contact region|cell-cell contact zone|intercellular junction http://purl.obolibrary.org/obo/GO_0005911 GO:0005918 biolink:CellularComponent septate junction A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods. NIF_Subcellular:sao427941916 go.json septate desmosome http://purl.obolibrary.org/obo/GO_0005918 GO:0005919 biolink:CellularComponent pleated septate junction A septate junction in which regular arrays of electron-dense septae span the intermembrane space. go.json pleated desmosome http://purl.obolibrary.org/obo/GO_0005919 GO:0005916 biolink:CellularComponent fascia adherens A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. Wikipedia:Fascia_adherens go.json http://purl.obolibrary.org/obo/GO_0005916 GO:0005917 biolink:CellularComponent nephrocyte diaphragm A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates. go.json nephrocyte junction http://purl.obolibrary.org/obo/GO_0005917 GO:0005914 biolink:CellularComponent spot adherens junction A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens. go.json dense plaque|punctum adherens http://purl.obolibrary.org/obo/GO_0005914 GO:0005915 biolink:CellularComponent zonula adherens A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. NIF_Subcellular:sao1400623473 go.json adhesion belt|belt desmosome|intermediate junction|zonula adhaerens http://purl.obolibrary.org/obo/GO_0005915 GO:0005923 biolink:CellularComponent bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. NIF_Subcellular:sao1939999134|Wikipedia:Tight_junction go.json zonula occludens http://purl.obolibrary.org/obo/GO_0005923 GO:0005924 biolink:CellularComponent obsolete cell-substrate adherens junction OBSOLETE. An adherens junction which connects a cell to the extracellular matrix. go.json hemi-adherens junction True http://purl.obolibrary.org/obo/GO_0005924 GO:0005921 biolink:CellularComponent gap junction A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins. NIF_Subcellular:sao118541872|Wikipedia:Gap_junction go.json communicating junction|electrical synapse|electrotonic synapse|gap junction macula|gap junction plaque|intercellular gap junction channel|macula communicans|zonula communicans http://purl.obolibrary.org/obo/GO_0005921 GO:0005922 biolink:CellularComponent connexin complex An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. NIF_Subcellular:sao445019788 go.json connexon|connexon complex http://purl.obolibrary.org/obo/GO_0005922 GO:0005920 biolink:CellularComponent smooth septate junction A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions. go.json zonula continua http://purl.obolibrary.org/obo/GO_0005920 GO:0005929 biolink:CellularComponent cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. FMA:67181|NIF_Subcellular:sao787716553|Wikipedia:Cilium go.json eukaryotic flagellum|flagellum|microtubule-based flagellum|primary cilium http://purl.obolibrary.org/obo/GO_0005929 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir GO:0005927 biolink:CellularComponent muscle tendon junction A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons. go.json myotendinous junction http://purl.obolibrary.org/obo/GO_0005927 GO:0005928 biolink:CellularComponent obsolete apical hemi-adherens junction OBSOLETE. A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle. go.json apical cell-substrate adherens junction|apical dense plaque True http://purl.obolibrary.org/obo/GO_0005928 GO:0005925 biolink:CellularComponent focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). Wikipedia:Focal_adhesion go.json HAJ|adhesion plaque|connecting hemi-adherens junction|focal contact|hemi-adherens junction http://purl.obolibrary.org/obo/GO_0005925 GO:0005926 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005926 GO:0015377 biolink:MolecularActivity chloride:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). TC:2.A.30 go.json cation:chloride cotransporter activity|cation:chloride symporter activity http://purl.obolibrary.org/obo/GO_0015377 GO:0015378 biolink:MolecularActivity sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). Reactome:R-HSA-426130|Reactome:R-HSA-5623705 go.json http://purl.obolibrary.org/obo/GO_0015378 GO:0015379 biolink:MolecularActivity potassium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). Reactome:R-HSA-426155|Reactome:R-HSA-5623806|TC:2.A.30.1.5 go.json potassium ion symporter activity http://purl.obolibrary.org/obo/GO_0015379 GO:0015373 biolink:MolecularActivity monoatomic anion:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in). go.json anion:sodium symporter activity|monovalent anion:sodium symporter activity http://purl.obolibrary.org/obo/GO_0015373 GO:0015374 biolink:MolecularActivity neutral, basic amino acid:sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in). go.json neutral, cationic amino acid:sodium:chloride symporter activity http://purl.obolibrary.org/obo/GO_0015374 GO:0015375 biolink:MolecularActivity glycine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). Reactome:R-HSA-444120|Reactome:R-HSA-5660840 go.json http://purl.obolibrary.org/obo/GO_0015375 GO:0015376 biolink:MolecularActivity obsolete betaine/GABA:sodium symporter activity OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in). go.json betaine/GABA:sodium symporter activity True http://purl.obolibrary.org/obo/GO_0015376 GO:0015370 biolink:MolecularActivity solute:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). Reactome:R-HSA-8876283 go.json proline/glycine/betaine:hydrogen/sodium symporter activity http://purl.obolibrary.org/obo/GO_0015370 GO:0015371 biolink:MolecularActivity galactose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in). go.json http://purl.obolibrary.org/obo/GO_0015371 GO:0015372 biolink:MolecularActivity obsolete glutamate/aspartate:sodium symporter activity OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in). go.json glutamate/aspartate:sodium symporter activity True http://purl.obolibrary.org/obo/GO_0015372 GO:0015390 biolink:MolecularActivity purine-specific nucleoside:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). go.json http://purl.obolibrary.org/obo/GO_0015390 GO:0015388 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015388 GO:0015389 biolink:MolecularActivity pyrimidine- and adenosine-specific:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). TC:2.A.41.2.3 go.json pyrimidine- and adenine-specific:sodium symporter activity http://purl.obolibrary.org/obo/GO_0015389 GO:0015384 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015384 GO:0015385 biolink:MolecularActivity sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). RHEA:29251|Reactome:R-HSA-2872444|Reactome:R-HSA-2872463|Reactome:R-HSA-2889070|Reactome:R-HSA-425965|Reactome:R-HSA-425983|Reactome:R-HSA-425994|Reactome:R-HSA-426015|Reactome:R-HSA-5661039|Reactome:R-HSA-5661086 go.json pH-dependent sodium:hydrogen antiporter activity|pH-dependent sodium:proton antiporter activity|sodium/hydrogen antiporter activity|sodium:hydrogen antiporter activity|sodium:hydrogen exchange activity|sodium:hydrogen exchanger http://purl.obolibrary.org/obo/GO_0015385 GO:0015386 biolink:MolecularActivity potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). RHEA:29467 go.json potassium:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015386 GO:0015387 biolink:MolecularActivity potassium:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in). RHEA:28490 go.json potassium:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015387 GO:0015380 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015380 GO:0015381 biolink:MolecularActivity high-affinity sulfate transmembrane transporter activity Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations. go.json high affinity sulfate permease activity|high affinity sulfate transmembrane transporter activity|high affinity sulphate permease activity http://purl.obolibrary.org/obo/GO_0015381 GO:0015382 biolink:MolecularActivity sodium:sulfate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in). Reactome:R-HSA-433099|Reactome:R-HSA-433114 go.json sodium:sulfate cotransporter activity|sodium:sulphate symporter activity http://purl.obolibrary.org/obo/GO_0015382 GO:0015383 biolink:MolecularActivity sulfate:bicarbonate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out). go.json sulphate:bicarbonate antiporter activity http://purl.obolibrary.org/obo/GO_0015383 GO:0030998 biolink:CellularComponent linear element A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex. go.json http://purl.obolibrary.org/obo/GO_0030998 GO:0030999 biolink:BiologicalProcess linear element assembly The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex. go.json linear element formation http://purl.obolibrary.org/obo/GO_0030999 GO:0030996 biolink:BiologicalProcess obsolete mitotic cell cycle arrest in response to nitrogen starvation OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen. go.json cell cycle arrest in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_0030996 GO:0030997 biolink:BiologicalProcess regulation of centriole-centriole cohesion Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker. go.json http://purl.obolibrary.org/obo/GO_0030997 GO:0030994 biolink:BiologicalProcess primary cell septum disassembly Dissolution of the primary septum during cell separation. go.json hydrolysis of primary cell septum|primary cell septum hydrolysis|primary septum hydrolysis http://purl.obolibrary.org/obo/GO_0030994 GO:0030995 biolink:BiologicalProcess cell septum edging catabolic process The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation. go.json cell septum edging hydrolysis|hydrolysis of cell septum edging|hydrolysis of edging of cell septum|septum edging hydrolysis http://purl.obolibrary.org/obo/GO_0030995 GO:0015359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015359 GO:0015355 biolink:MolecularActivity secondary active monocarboxylate transmembrane transporter activity Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. go.json monocarboxylate porter activity http://purl.obolibrary.org/obo/GO_0015355 GO:0015356 biolink:MolecularActivity obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity OBSOLETE. (Was not defined before being made obsolete). go.json monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity True http://purl.obolibrary.org/obo/GO_0015356 GO:0015357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015357 GO:0015358 biolink:MolecularActivity obsolete amino acid/choline transmembrane transporter activity OBSOLETE. (Was not defined before being made obsolete). go.json amino acid/choline transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_0015358 GO:0030992 biolink:CellularComponent intraciliary transport particle B The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. go.json IFT B complex|IFT complex B|intraflagellar transport complex B|intraflagellar transport particle B http://purl.obolibrary.org/obo/GO_0030992 GO:0015351 biolink:MolecularActivity bilirubin secondary active transmembrane transporter activity Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json bilirubin porter activity|bilitranslocase http://purl.obolibrary.org/obo/GO_0015351 GO:0015352 biolink:MolecularActivity obsolete secondary active sterol transmembrane transporter activity OBSOLETE. Enables the transfer of sterol from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. go.json sterol porter activity True http://purl.obolibrary.org/obo/GO_0015352 GO:0030993 biolink:CellularComponent axonemal heterotrimeric kinesin-II complex A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme. go.json http://purl.obolibrary.org/obo/GO_0030993 GO:0030990 biolink:CellularComponent intraciliary transport particle A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. go.json IFT complex|intraflagellar transport complex|intraflagellar transport particle http://purl.obolibrary.org/obo/GO_0030990 goslim_pir GO:0015353 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015353 GO:0030991 biolink:CellularComponent intraciliary transport particle A The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa. go.json IFT A complex|IFT complex A|intraflagellar transport complex A|intraflagellar transport particle A http://purl.obolibrary.org/obo/GO_0030991 GO:0015354 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015354 GO:0015350 biolink:MolecularActivity methotrexate transmembrane transporter activity Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. go.json methotrexate transporter activity http://purl.obolibrary.org/obo/GO_0015350 GO:0030989 biolink:BiologicalProcess dynein-driven meiotic oscillatory nuclear movement Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein. go.json HNM|horsetail movement|horsetail nuclear movement http://purl.obolibrary.org/obo/GO_0030989 GO:0030987 biolink:MolecularActivity high molecular weight kininogen receptor binding Binding to a high molecular weight kininogen receptor. go.json http://purl.obolibrary.org/obo/GO_0030987 GO:0030988 biolink:CellularComponent high molecular weight kininogen receptor complex A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins. go.json http://purl.obolibrary.org/obo/GO_0030988 GO:0030985 biolink:MolecularActivity high molecular weight kininogen binding Binding to a kininogen of high molecular mass. go.json HK binding|HMW kininogen binding http://purl.obolibrary.org/obo/GO_0030985 GO:0030986 biolink:MolecularActivity low molecular weight kininogen binding Binding to a kininogen of low molecular mass. go.json LK binding|LMW kininogen binding http://purl.obolibrary.org/obo/GO_0030986 GO:0030983 biolink:MolecularActivity mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches. go.json mispair binding|mispaired DNA binding http://purl.obolibrary.org/obo/GO_0030983 GO:0030984 biolink:MolecularActivity kininogen binding Binding to a kininogen, a kinin precursor. go.json http://purl.obolibrary.org/obo/GO_0030984 GO:0015366 biolink:MolecularActivity malate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in). go.json L-malic acid permease|L-malic acid:proton symporter activity|malate permease|malate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015366 GO:0015367 biolink:MolecularActivity oxoglutarate:malate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out). Reactome:R-HSA-198440|Reactome:R-HSA-376851 go.json 2-oxoglutarate/malate carrier protein http://purl.obolibrary.org/obo/GO_0015367 GO:0015368 biolink:MolecularActivity calcium:monoatomic cation antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). Reactome:R-HSA-425822 go.json calcium:cation antiporter activity http://purl.obolibrary.org/obo/GO_0015368 GO:0015369 biolink:MolecularActivity calcium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). RHEA:71799|Reactome:R-HSA-8949687 go.json calcium:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015369 GO:0015362 biolink:MolecularActivity high-affinity sodium:dicarboxylate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Reactome:R-HSA-433101 go.json high affinity sodium:dicarboxylate cotransporter activity|high affinity sodium:dicarboxylate symporter activity http://purl.obolibrary.org/obo/GO_0015362 GO:0030981 biolink:CellularComponent cortical microtubule cytoskeleton The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0030981 GO:0015363 biolink:MolecularActivity obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity OBSOLETE. (Was not defined before being made obsolete). go.json dicarboxylate (succinate/fumarate/malate) antiporter activity True http://purl.obolibrary.org/obo/GO_0015363 GO:0030982 biolink:BiologicalProcess adventurous gliding motility A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime. go.json adventurous gliding movement http://purl.obolibrary.org/obo/GO_0030982 GO:0015364 biolink:MolecularActivity dicarboxylate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out). go.json http://purl.obolibrary.org/obo/GO_0015364 GO:0030980 biolink:BiologicalProcess alpha-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-glucans. go.json alpha-glucan breakdown|alpha-glucan catabolism|alpha-glucan degradation http://purl.obolibrary.org/obo/GO_0030980 GO:0015365 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015365 GO:0015360 biolink:MolecularActivity acetate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in). go.json acetate:hydrogen symporter activity|hydrogen:acetate symporter activity http://purl.obolibrary.org/obo/GO_0015360 GO:0015361 biolink:MolecularActivity low-affinity sodium:dicarboxylate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Reactome:R-HSA-433131 go.json low affinity sodium:dicarboxylate cotransporter activity|low affinity sodium:dicarboxylate symporter activity http://purl.obolibrary.org/obo/GO_0015361 GO:0030978 biolink:BiologicalProcess alpha-glucan metabolic process The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. go.json alpha-glucan metabolism http://purl.obolibrary.org/obo/GO_0030978 GO:0030979 biolink:BiologicalProcess alpha-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. go.json alpha-glucan anabolism|alpha-glucan biosynthesis|alpha-glucan formation|alpha-glucan synthesis http://purl.obolibrary.org/obo/GO_0030979 GO:0030976 biolink:MolecularActivity thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. go.json TPP binding|aneurine pyrophosphate binding|cocarboxylase binding|diphosphothiamin binding|thiamin pyrophosphate binding http://purl.obolibrary.org/obo/GO_0030976 GO:0030977 biolink:MolecularActivity taurine binding Binding to taurine. go.json http://purl.obolibrary.org/obo/GO_0030977 GO:0030974 biolink:BiologicalProcess thiamine pyrophosphate transmembrane transport The process in which thiamine pyrophosphate is transported across a membrane. go.json TPP transport|thiamin diphosphate transport|thiamin pyrophosphate transport|thiamine diphosphate transport|thiamine pyrophosphate transport http://purl.obolibrary.org/obo/GO_0030974 GO:0030975 biolink:MolecularActivity thiamine binding Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. go.json thiamin binding|vitamin B1 binding http://purl.obolibrary.org/obo/GO_0030975 GO:0030972 biolink:BiologicalProcess obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis. go.json apoptotic cleavage of cytosolic proteins|cleavage of cytosolic proteins involved in apoptosis|cleavage of cytosolic proteins involved in execution phase of apoptosis True http://purl.obolibrary.org/obo/GO_0030972 GO:0030973 biolink:MolecularActivity molybdate ion binding Binding to a molybdate ion (MoO4 2-). go.json MoO4 ion binding http://purl.obolibrary.org/obo/GO_0030973 GO:0015337 biolink:MolecularActivity obsolete low affinity metal ion uptake transporter activity OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+. go.json low affinity metal ion uptake transporter activity True http://purl.obolibrary.org/obo/GO_0015337 GO:0015338 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015338 GO:0015339 biolink:MolecularActivity obsolete cobalt, zinc uptake permease activity OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport. go.json cobalt, zinc uptake permease activity True http://purl.obolibrary.org/obo/GO_0015339 GO:0015333 biolink:MolecularActivity peptide:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. RHEA:37047|Reactome:R-HSA-427998|Reactome:R-HSA-428007 go.json peptide:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015333 GO:0015334 biolink:MolecularActivity high-affinity oligopeptide transmembrane transporter activity Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. go.json high affinity oligopeptide transporter activity|high-affinity oligopeptide transporter activity http://purl.obolibrary.org/obo/GO_0015334 GO:0015335 biolink:MolecularActivity obsolete heavy metal ion:hydrogen symporter activity OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+. go.json heavy metal ion:hydrogen symporter activity|heavy metal ion:proton symporter activity True http://purl.obolibrary.org/obo/GO_0015335 GO:0015336 biolink:MolecularActivity obsolete high affinity metal ion uptake transporter activity OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+. go.json high affinity metal ion uptake transporter activity True http://purl.obolibrary.org/obo/GO_0015336 GO:0030970 biolink:BiologicalProcess retrograde protein transport, ER to cytosol The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. go.json protein dislocation from ER|protein retrotranslocation, ER to cytosol|retrograde protein transport, endoplasmic reticulum to cytosol http://purl.obolibrary.org/obo/GO_0030970 GO:0030971 biolink:MolecularActivity receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity. go.json transmembrane receptor protein tyrosine kinase ligand binding http://purl.obolibrary.org/obo/GO_0030971 GO:0015330 biolink:MolecularActivity high-affinity glutamine transmembrane transporter activity Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity glutamine permease activity|high affinity glutamine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015330 GO:0015331 biolink:MolecularActivity obsolete asparagine/glutamine permease activity OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane. go.json asparagine/glutamine permease activity True http://purl.obolibrary.org/obo/GO_0015331 GO:0015332 biolink:MolecularActivity obsolete leucine/valine/isoleucine permease activity OBSOLETE. (Was not defined before being made obsolete). go.json leucine/valine/isoleucine permease activity True http://purl.obolibrary.org/obo/GO_0015332 GO:0030967 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030967 GO:0030968 biolink:BiologicalProcess endoplasmic reticulum unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. go.json ER unfolded protein response|SREBP-mediated signalling pathway|erUPR http://purl.obolibrary.org/obo/GO_0030968 GO:0030965 biolink:BiologicalProcess plasma membrane electron transport, NADH to quinone The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase. go.json http://purl.obolibrary.org/obo/GO_0030965 GO:0030966 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030966 GO:0030963 biolink:BiologicalProcess peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine. RESID:AA0370 go.json http://purl.obolibrary.org/obo/GO_0030963 gocheck_do_not_annotate GO:0030964 biolink:CellularComponent NADH dehydrogenase complex An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. Wikipedia:NADH_dehydrogenase go.json Complex I|NADH dehydrogenase complex (plastoquinone)|NADH dehydrogenase complex (quinone)|NADH dehydrogenase complex (ubiquinone)|NADH:plastoquinone reductase complex|plastid NADH dehydrogenase complex (plastoquinone) http://purl.obolibrary.org/obo/GO_0030964 goslim_pir GO:0030961 biolink:BiologicalProcess peptidyl-arginine hydroxylation The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine. go.json http://purl.obolibrary.org/obo/GO_0030961 gocheck_do_not_annotate GO:0030962 biolink:BiologicalProcess peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine. RESID:AA0369 go.json http://purl.obolibrary.org/obo/GO_0030962 gocheck_do_not_annotate GO:0030969 biolink:BiologicalProcess obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response OBSOLETE. The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes. go.json HAC1 mRNA splicing|IRE1-mediated XBP-1 mRNA splicing|Ire1p-mediated HAC-1 mRNA splicing|UFP-specific transcription factor mRNA processing during unfolded protein response|UFP-specific transcription factor mRNA processing involved in ER UPR|UFP-specific transcription factor mRNA processing involved in ER unfolded protein response|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum UPR|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|XBP1 mRNA splicing|XBP1 mRNA splicing under conditions of endoplasmic reticulum (ER) stress|XBP1 mRNA splicing, via endonucleolytic cleavage and ligation|non-spliceosomal mRNA splicing in the unfolded protein response pathway|spliceosome-independent UFP-specific transcription factor mRNA processing|unconventional mRNA splicing involved in UPR|unconventional splicing of XBP1 mRNA|unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor|unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase True http://purl.obolibrary.org/obo/GO_0030969 GO:0015348 biolink:MolecularActivity obsolete prostaglandin/thromboxane transporter activity OBSOLETE. (Was not defined before being made obsolete). go.json prostaglandin/thromboxane transporter activity True http://purl.obolibrary.org/obo/GO_0015348 GO:0015349 biolink:MolecularActivity thyroid hormone transmembrane transporter activity Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. Reactome:R-HSA-879575|Reactome:R-HSA-9631987 go.json http://purl.obolibrary.org/obo/GO_0015349 GO:0015344 biolink:MolecularActivity siderophore uptake transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). go.json ferrioxamine uptake transmembrane transporter activity|siderochrome-iron (ferrioxamine) uptake transporter|siderophore-iron uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015344 GO:0015345 biolink:MolecularActivity ferric enterobactin:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in). go.json ferric enterobactin:hydrogen symporter activity|ferric-enterobactin:proton symporter activity http://purl.obolibrary.org/obo/GO_0015345 GO:0015346 biolink:MolecularActivity ferric triacetylfusarinine C:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in). go.json ferric triacetylfusarinine C:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015346 GO:0015347 biolink:MolecularActivity sodium-independent organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. Reactome:R-HSA-561059|Reactome:R-HSA-879562|Reactome:R-HSA-879584|Reactome:R-HSA-879594|Reactome:R-HSA-9661397|Reactome:R-HSA-9661446|Reactome:R-HSA-9661723|Reactome:R-HSA-9661799|Reactome:R-HSA-9749583|Reactome:R-HSA-9749607|Reactome:R-HSA-9757010 go.json http://purl.obolibrary.org/obo/GO_0015347 GO:0015340 biolink:MolecularActivity obsolete zinc, cadmium uptake permease activity OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport. go.json zinc, cadmium uptake permease activity True http://purl.obolibrary.org/obo/GO_0015340 GO:0030960 biolink:BiologicalProcess peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link. RESID:AA0368 go.json http://purl.obolibrary.org/obo/GO_0030960 gocheck_do_not_annotate GO:0015341 biolink:MolecularActivity zinc efflux active transmembrane transporter activity Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force. go.json zinc efflux permease activity http://purl.obolibrary.org/obo/GO_0015341 GO:0015342 biolink:MolecularActivity obsolete zinc, iron permease activity OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force. go.json zinc, iron permease activity True http://purl.obolibrary.org/obo/GO_0015342 GO:0015343 biolink:MolecularActivity siderophore-iron transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). Reactome:R-HSA-1222597 go.json iron-siderophore transporter activity|siderochrome transporter activity|siderochrome-iron transporter activity|siderophore transmembrane transporter activity|siderophore transporter activity|siderophore-iron transporter activity http://purl.obolibrary.org/obo/GO_0015343 GO:0030956 biolink:CellularComponent glutamyl-tRNA(Gln) amidotransferase complex A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. go.json AdT|GatCAB|GatFAB http://purl.obolibrary.org/obo/GO_0030956 GO:0030957 biolink:MolecularActivity Tat protein binding Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. go.json http://purl.obolibrary.org/obo/GO_0030957 GO:0005998 biolink:BiologicalProcess xylulose catabolic process The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose. MetaCyc:XYLCAT-PWY go.json xylulose breakdown|xylulose catabolism|xylulose degradation http://purl.obolibrary.org/obo/GO_0005998 GO:0030954 biolink:BiologicalProcess astral microtubule nucleation The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. go.json http://purl.obolibrary.org/obo/GO_0030954 GO:0005999 biolink:BiologicalProcess xylulose biosynthetic process The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose. go.json xylulose anabolism|xylulose biosynthesis|xylulose formation|xylulose synthesis http://purl.obolibrary.org/obo/GO_0005999 GO:0030955 biolink:MolecularActivity potassium ion binding Binding to a potassium ion (K+). go.json K ion binding http://purl.obolibrary.org/obo/GO_0030955 GO:0030952 biolink:BiologicalProcess establishment or maintenance of cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. go.json cytoskeleton polarization http://purl.obolibrary.org/obo/GO_0030952 GO:0005996 biolink:BiologicalProcess monosaccharide metabolic process The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. go.json monosaccharide metabolism http://purl.obolibrary.org/obo/GO_0005996 GO:0005997 biolink:BiologicalProcess xylulose metabolic process The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose. go.json xylulose metabolism http://purl.obolibrary.org/obo/GO_0005997 GO:0030953 biolink:BiologicalProcess astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. go.json astral microtubule organisation|astral microtubule organization and biogenesis http://purl.obolibrary.org/obo/GO_0030953 GO:0005994 biolink:BiologicalProcess melibiose metabolic process The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. go.json melibiose metabolism http://purl.obolibrary.org/obo/GO_0005994 GO:0030950 biolink:BiologicalProcess establishment or maintenance of actin cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures. go.json http://purl.obolibrary.org/obo/GO_0030950 GO:0005995 biolink:BiologicalProcess melibiose catabolic process The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. go.json melibiose breakdown|melibiose catabolism|melibiose degradation http://purl.obolibrary.org/obo/GO_0005995 GO:0030951 biolink:BiologicalProcess establishment or maintenance of microtubule cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. go.json http://purl.obolibrary.org/obo/GO_0030951 GO:0005992 biolink:BiologicalProcess trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. MetaCyc:PWY-881|MetaCyc:TREHALOSESYN-PWY|MetaCyc:TRESYN-PWY go.json mycose biosynthesis|mycose biosynthetic process|mykose biosynthesis|mykose biosynthetic process|trehalose anabolism|trehalose biosynthesis|trehalose formation|trehalose synthesis http://purl.obolibrary.org/obo/GO_0005992 GO:0005993 biolink:BiologicalProcess trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. MetaCyc:TREDEGLOW-PWY go.json mycose catabolic process|mycose catabolism|mykose catabolic process|mykose catabolism|trehalose breakdown|trehalose catabolism|trehalose degradation http://purl.obolibrary.org/obo/GO_0005993 GO:0005990 biolink:BiologicalProcess lactose catabolic process The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose. go.json lactose breakdown|lactose catabolism|lactose degradation http://purl.obolibrary.org/obo/GO_0005990 GO:0005991 biolink:BiologicalProcess trehalose metabolic process The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. go.json mycose metabolic process|mycose metabolism|mykose metabolic process|mykose metabolism|trehalose metabolism http://purl.obolibrary.org/obo/GO_0005991 GO:0015319 biolink:MolecularActivity sodium:inorganic phosphate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in). go.json http://purl.obolibrary.org/obo/GO_0015319 GO:0030958 biolink:CellularComponent RITS complex A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing. go.json http://purl.obolibrary.org/obo/GO_0030958 GO:0030959 biolink:BiologicalProcess peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link. RESID:AA0367 go.json http://purl.obolibrary.org/obo/GO_0030959 gocheck_do_not_annotate GO:0015315 biolink:MolecularActivity organophosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out). go.json http://purl.obolibrary.org/obo/GO_0015315 GO:0015316 biolink:MolecularActivity obsolete nitrite/nitrate porter activity OBSOLETE. (Was not defined before being made obsolete). go.json nitrite/nitrate porter activity True http://purl.obolibrary.org/obo/GO_0015316 GO:0015317 biolink:MolecularActivity phosphate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in). go.json phosphate ion carrier activity|phosphate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015317 GO:0015318 biolink:MolecularActivity inorganic molecular entity transmembrane transporter activity Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. go.json inorganic solute uptake transmembrane transporter activity|inorganic uptake permease activity http://purl.obolibrary.org/obo/GO_0015318 gocheck_do_not_annotate GO:0015311 biolink:MolecularActivity monoamine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out). go.json monoamine:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015311 GO:0015312 biolink:MolecularActivity polyamine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out). go.json polyamine:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015312 GO:0015313 biolink:MolecularActivity fluconazole:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out). go.json fluconazole:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015313 GO:0015314 biolink:MolecularActivity aminotriazole:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out). go.json aminotriazole:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015314 GO:0015310 biolink:MolecularActivity benomyl:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out). go.json benomyl:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015310 GO:0030945 biolink:MolecularActivity protein tyrosine phosphatase activity, via thiol-phosphate intermediate The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. go.json http://purl.obolibrary.org/obo/GO_0030945 GO:0030946 biolink:MolecularActivity protein tyrosine phosphatase activity, metal-dependent Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions. go.json http://purl.obolibrary.org/obo/GO_0030946 GO:0030943 biolink:MolecularActivity mitochondrion targeting sequence binding Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. go.json mitochondrial targeting sequence binding http://purl.obolibrary.org/obo/GO_0030943 GO:0030944 biolink:MolecularActivity DDEL sequence binding Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0030944 GO:0030941 biolink:MolecularActivity chloroplast targeting sequence binding Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast. go.json http://purl.obolibrary.org/obo/GO_0030941 GO:0030942 biolink:MolecularActivity endoplasmic reticulum signal peptide binding Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. go.json ER signal peptide binding http://purl.obolibrary.org/obo/GO_0030942 GO:0030940 biolink:BiologicalProcess obsolete response to short-day photoperiod OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light. go.json response to short-day photoperiod True http://purl.obolibrary.org/obo/GO_0030940 GO:0030949 biolink:BiologicalProcess positive regulation of vascular endothelial growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. go.json activation of vascular endothelial growth factor receptor signaling pathway|positive regulation of VEGF receptor signaling pathway|positive regulation of VEGF receptor signalling pathway|positive regulation of vascular endothelial growth factor receptor signalling pathway|stimulation of vascular endothelial growth factor receptor signaling pathway|up regulation of vascular endothelial growth factor receptor signaling pathway|up-regulation of vascular endothelial growth factor receptor signaling pathway|upregulation of vascular endothelial growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030949 GO:0030947 biolink:BiologicalProcess regulation of vascular endothelial growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. go.json regulation of VEGF receptor signaling pathway|regulation of VEGF receptor signalling pathway|regulation of vascular endothelial growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0030947 GO:0030948 biolink:BiologicalProcess negative regulation of vascular endothelial growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. go.json down regulation of vascular endothelial growth factor receptor signaling pathway|down-regulation of vascular endothelial growth factor receptor signaling pathway|downregulation of vascular endothelial growth factor receptor signaling pathway|inhibition of vascular endothelial growth factor receptor signaling pathway|negative regulation of VEGF receptor signaling pathway|negative regulation of VEGF receptor signalling pathway|negative regulation of vascular endothelial growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0030948 GO:0015326 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015326 GO:0015327 biolink:MolecularActivity cystine:glutamate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). go.json http://purl.obolibrary.org/obo/GO_0015327 GO:0015328 biolink:MolecularActivity cystine secondary active transmembrane transporter activity Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json cystine porter activity|cystinosin|lysosomal cystine transporter http://purl.obolibrary.org/obo/GO_0015328 GO:0015329 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015329 GO:0015322 biolink:MolecularActivity secondary active oligopeptide transmembrane transporter activity Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. go.json oligopeptide porter activity http://purl.obolibrary.org/obo/GO_0015322 GO:0015323 biolink:MolecularActivity obsolete type V protein secretor activity OBSOLETE. This term was not defined before being made obsolete. go.json type V protein secretor activity True http://purl.obolibrary.org/obo/GO_0015323 GO:0015324 biolink:MolecularActivity peptide-acetyl-CoA secondary active transmembrane transporter activity Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json peptide-acetyl-CoA transporter activity http://purl.obolibrary.org/obo/GO_0015324 GO:0015325 biolink:MolecularActivity acetyl-CoA:CoA antiporter activity Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out). go.json http://purl.obolibrary.org/obo/GO_0015325 GO:0015320 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015320 GO:0015321 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015321 GO:1990196 biolink:CellularComponent MacAB-TolC complex The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC. go.json macrolide transporter MacAB-TolC complex http://purl.obolibrary.org/obo/GO_1990196 GO:1990197 biolink:CellularComponent methionine-importing ABC transporter complex An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner. go.json ATP-binding cassette (ABC) methionine importer complex|ATP-dependent methionine importer complex|ATP-dependent methionine importing complex|ATP-dependent methionine-importing complex|MetNI complex|MetNI transport complex|MetNI transporter|MetNI transporter complex|MetNIQ complex|MetNIQ transport complex|MetNIQ transporter|MetNIQ transporter complex|methionine transport complex|methionine transporter|methionine transporter complex|methionine transporter complex, ATP-dependent http://purl.obolibrary.org/obo/GO_1990197 GO:1990198 biolink:CellularComponent ModE complex A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism. go.json ModE dimer http://purl.obolibrary.org/obo/GO_1990198 GO:1990199 biolink:CellularComponent MsbA transporter complex An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD). go.json MsbA complex|MsbA dimer http://purl.obolibrary.org/obo/GO_1990199 GO:1990192 biolink:BiologicalProcess collecting lymphatic vessel constriction A decrease in the diameter of collecting lymphatic vessels. go.json lymphatic vessel myogenic constriction http://purl.obolibrary.org/obo/GO_1990192 GO:1990193 biolink:CellularComponent BtuCD complex Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer. go.json BtuC-BtuD complex|cobalamin transport complex, core subunit|vitamin B12 transport complex, core subunit http://purl.obolibrary.org/obo/GO_1990193 GO:1990194 biolink:BiologicalProcess cytoplasmic U snRNP body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body. go.json U body assembly http://purl.obolibrary.org/obo/GO_1990194 GO:1990195 biolink:CellularComponent macrolide transmembrane transporter complex A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. go.json AcrAB-TolC complex|MacAB-TolC complex|macrolide transporter|macrolide transporter complex http://purl.obolibrary.org/obo/GO_1990195 GO:0015418 biolink:MolecularActivity ABC-type quaternary ammonium compound transporting activity Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in). EC:7.6.2.9|MetaCyc:RXN-8665|RHEA:11036 go.json ATP-dependent quaternary-ammonium compound transmembrane transporting activity|ATPase-coupled quaternary ammonium compound transmembrane transporting activity|glycine betaine/proline porter activity|quarternary amine transporter activity|quaternary amine uptake transporter activity|quaternary-amine-transporting ATPase activity|quaternary-ammonium-compound ABC transporter|quaternary-ammonium-compound-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015418 GO:0015419 biolink:MolecularActivity ABC-type sulfate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). EC:7.3.2.3|MetaCyc:3.6.3.25-RXN|RHEA:10192 go.json ATPase-coupled sulfate transmembrane transporter activity|sulfate ABC transporter|sulfate transmembrane-transporting ATPase activity|sulfate-transporting ATPase activity|sulfate/thiosulfate porter activity|sulphate transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015419 GO:1990190 biolink:MolecularActivity peptide-glutamate-alpha-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide. go.json http://purl.obolibrary.org/obo/GO_1990190 GO:1990191 biolink:CellularComponent cobalamin transport complex Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD. go.json BtuCDF complex|cobalamin-transporting BtuCDF complex|vitamin B12 transport complex|vitamin B12-transporting BtuCDF complex http://purl.obolibrary.org/obo/GO_1990191 GO:0015414 biolink:MolecularActivity ABC-type nitrate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in). EC:7.3.2.4|MetaCyc:3.6.3.26-RXN|RHEA:13181 go.json ATPase-coupled nitrate transmembrane transporter activity|nitrate ABC transporter|nitrate transmembrane-transporting ATPase activity|nitrate transporting ATPase activity|nitrate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015414 GO:0015415 biolink:MolecularActivity ATPase-coupled phosphate ion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in). EC:7.3.2.1|RHEA:24440 go.json ABC phosphate transporter activity|ATP phosphohydrolase (phosphate-importing)|phosphate ABC transporter|phosphate ion transmembrane-transporting ATPase activity|phosphate porter activity|phosphate transporting ATPase activity|phosphate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015415 GO:0015416 biolink:MolecularActivity ABC-type phosphonate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). EC:7.3.2.2|MetaCyc:3.6.3.28-RXN|MetaCyc:ABC-23-RXN|RHEA:18065 go.json ATP phosphohydrolase (phosphonate-transporting)|ATPase-coupled alkylphosphonate transmembrane transporter activity|ATPase-coupled organic phosphonate transmembrane transporter activity|alkylphosphonate ABC transporter activity|alkylphosphonate transmembrane transporter activity|alkylphosphonate transmembrane-transporting ATPase activity|organic phosphonate transmembrane transporter activity|organic phosphonate transmembrane-transporting ATPase activity|phosphonate ABC transporter|phosphonate transporting ATPase activity|phosphonate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015416 GO:0015417 biolink:MolecularActivity ABC-type polyamine transporter activity Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). EC:7.6.2.11|MetaCyc:3.6.3.31-RXN|MetaCyc:ABC-24-RXN|RHEA:29999 go.json ATP-dependent polyamine transmembrane transporter activity|ATPase-coupled polyamine transmembrane transporter activity|ATPase-coupled spermidine transmembrane transporter activity|polyamine ABC transporter|polyamine porter activity|polyamine-importing ATPase activity|polyamine-transporting ATPase activity|spermidine porter activity|spermidine-importing ATPase activity http://purl.obolibrary.org/obo/GO_0015417 GO:0015410 biolink:MolecularActivity ABC-type manganese transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in). EC:7.2.2.5|MetaCyc:3.6.3.35-RXN|RHEA:17365|Reactome:R-HSA-5692462 go.json ABC-type Mn(2+) transporter|ATP-dependent manganese transmembrane transporter activity|ATPase-coupled manganese transmembrane transporter activity|manganese ABC transporter|manganese transmembrane transporter activity, phosphorylative mechanism|manganese-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015410 GO:0015411 biolink:MolecularActivity ABC-type taurine transporter transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in). EC:7.6.2.7|MetaCyc:ABC-70-RXN|RHEA:14613 go.json ATP-dependent taurine transporter activity|ATPase-coupled taurine transporter activity|taurine ABC transporter|taurine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015411 GO:0015412 biolink:MolecularActivity ABC-type molybdate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in). EC:7.3.2.5|MetaCyc:ABC-19-RXN|RHEA:22020 go.json ATPase-coupled molybdate transmembrane transporter activity|molybdate ABC transporter|molybdate porter activity|molybdate transmembrane-transporting ATPase activity|molybdate transporting ATPase activity|molybdate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015412 GO:0015413 biolink:MolecularActivity ABC-type nickel transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). EC:7.2.2.11|MetaCyc:ABC-20-RXN|RHEA:15557 go.json ATP-dependent nickel transmembrane transporter activity|ATPase-coupled nickel transmembrane transporter activity|nickel ABC transporter|nickel ABC transporter activity|nickel porter activity|nickel transporting ATPase activity|nickel-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015413 GO:0015429 biolink:MolecularActivity obsolete peroxisomal fatty acyl transporter OBSOLETE. (Was not defined before being made obsolete). go.json peroxisomal fatty acyl transporter True http://purl.obolibrary.org/obo/GO_0015429 GO:0015425 biolink:MolecularActivity ATPase-coupled nonpolar-amino acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). EC:7.4.2.2|MetaCyc:3.6.3.22-RXN|TC:3.A.1.4.1 go.json ATP-dependent nonpolar-amino acid transporter activity|leucine/isoleucine/valine porter activity|nonpolar amino acid-transporting ATPase activity|nonpolar-amino acid ABC transporter|nonpolar-amino acid-transporting ATPase activity|nonpolar-amino-acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015425 GO:0015426 biolink:MolecularActivity ATPase-coupled polar amino acid-transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). EC:7.4.2.1|MetaCyc:3.6.3.21-RXN|RHEA:14673 go.json ATP-dependent polar amino acid-transporter activity|cystine/diaminopimelate porter activity|glutamate/aspartate porter activity|histidine permease activity|histidine/arginine/lysine/ornithine porter activity|polar amino acid uptake transporter activity|polar amino acid-importing ATPase activity|polar-amino acid ABC transporter|polar-amino acid-importing ATPase activity|polar-amino acid-transporting ATPase activity|polar-amino-acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015426 GO:0015427 biolink:MolecularActivity obsolete ABC-type efflux porter activity OBSOLETE. (Was not defined before being made obsolete). go.json ABC-type efflux porter activity True http://purl.obolibrary.org/obo/GO_0015427 GO:0015428 biolink:MolecularActivity obsolete type I protein secretor activity OBSOLETE. This term was not defined before being made obsolete. go.json type I protein secretor activity True http://purl.obolibrary.org/obo/GO_0015428 GO:0015421 biolink:MolecularActivity ABC-type oligopeptide transporter activity Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in). EC:7.4.2.6|MetaCyc:3.6.3.23-RXN|RHEA:37271|Reactome:R-HSA-5223317 go.json ABC-type oligopeptide transporter|ATP-dependent oligopeptide transmembrane transporter activity|ATPase-coupled oligopeptide transmembrane transporter activity|oligopeptide ABC transporter|oligopeptide permease activity|oligopeptide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015421 GO:0015422 biolink:MolecularActivity ABC-type oligosaccharide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in). EC:7.5.2.2|MetaCyc:3.6.3.18-RXN go.json ABC-type oligosaccharide transporter|ATP-dependent oligosaccharide transmembrane transporter activity|ATPase-coupled oligosaccharide transmembrane transporter activity|oligosaccharide ABC transporter|oligosaccharide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015422 GO:0015423 biolink:MolecularActivity ABC-type maltose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). EC:7.5.2.1|MetaCyc:3.6.3.19-RXN|RHEA:22132 go.json ABC-type maltose transporter|ATP-dependent maltose transmembrane transporter activity|ATPase-coupled maltose transmembrane transporter activity|maltooligosaccharide-importing ATPase activity|maltose ABC transporter|maltose-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015423 GO:0015424 biolink:MolecularActivity ABC-type amino acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). go.json ATP-dependent amino acid transmembrane transporter activity|ATPase-coupled amino acid transmembrane transporter activity|amino acid ABC transporter|amino acid-exporting ATPase activity|amino acid-importing ATPase activity|amino acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015424 GO:0015420 biolink:MolecularActivity ABC-type vitamin B12 transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. EC:7.6.2.8|MetaCyc:3.6.3.33-RXN|MetaCyc:ABC-5-RXN|RHEA:17873|Reactome:R-HSA-3095901|Reactome:R-HSA-5223313|Reactome:R-HSA-5683325|Reactome:R-HSA-9759206 go.json ATP-dependent cobalamin transmembrane transporter activity|ATP-dependent vitamin B12 transmembrane transporter activity|ATPase-coupled cobalamin transmembrane transporter activity|ATPase-coupled vitamin B12 transmembrane transporter activity|cobalamin ABC transporter|cobalamin porter activity|cobalamin transporter activity|cobalamin-transporting ATPase activity|vitamin B12 ABC transporter activity|vitamin B12 porter activity|vitamin B12 transporter activity|vitamin B12-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015420 GO:0015407 biolink:MolecularActivity ABC-type monosaccharide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported. EC:7.5.2.-|MetaCyc:3.6.3.17-RXN go.json ATP-dependent monosaccharide transmembrane transporter activity|ATPase-coupled monosaccharide transmembrane transporter activity|monosaccharide ABC transporter|monosaccharide-importing ATPase activity|monosaccharide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015407 GO:0015408 biolink:MolecularActivity ABC-type ferric iron transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). EC:7.2.2.7|MetaCyc:3.6.3.30-RXN|RHEA:12332 go.json ABC-type Fe3+ transporter|ATPase-coupled ferric iron transmembrane transporter activity|Fe3+-transporting ATPase activity|ferric ABC transporter|ferric transporting ATPase activity|ferric-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015408 GO:0015409 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015409 GO:0015403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015403 GO:0015404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015404 GO:0015405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015405 GO:0015406 biolink:MolecularActivity obsolete ABC-type uptake permease activity OBSOLETE. (Was not defined before being made obsolete). go.json ABC-type uptake permease activity True http://purl.obolibrary.org/obo/GO_0015406 GO:0015400 biolink:MolecularActivity low-affinity secondary active ammonium transmembrane transporter activity Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity ammonium transmembrane transporter activity|low affinity secondary active ammonium transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015400 GO:0015401 biolink:MolecularActivity urea:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in). go.json urea active transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015401 GO:0015402 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015402 GO:1990156 biolink:CellularComponent DnaB-DnaG complex A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes. go.json DnaB-DnaG primosome complex http://purl.obolibrary.org/obo/GO_1990156 GO:1990157 biolink:CellularComponent DnaA-DnaB-DnaC complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation. go.json http://purl.obolibrary.org/obo/GO_1990157 GO:1990158 biolink:CellularComponent DnaB-DnaC-DnaT-PriA-PriB complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. go.json DnaB-DnaC-DnaT-PriA-PriB preprimosome|phi-X174-type preprimosome http://purl.obolibrary.org/obo/GO_1990158 GO:1990159 biolink:CellularComponent DnaB-DnaC-DnaT-PriA-PriC complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. go.json DnaB-DnaC-DnaT-PriA-PriC preprimosome|phi-X174-type preprimosome http://purl.obolibrary.org/obo/GO_1990159 GO:1990152 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990152 GO:1990153 biolink:BiologicalProcess maintenance of protein localization to heterochromatin A process in which a protein is maintained in a location in telomeric heterochromatin. go.json maintenance of protein localisation to heterochromatin|maintenance of protein location in heterochromatin http://purl.obolibrary.org/obo/GO_1990153 GO:1990154 biolink:CellularComponent enzyme IIA-maltose transporter complex A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter. go.json EIIA(Glc)-MalFGK2 complex|EIIA(Glc)-maltose transporter complex|maltose transporter inhibitor complex http://purl.obolibrary.org/obo/GO_1990154 GO:1990155 biolink:BiologicalProcess Dsc E3 ubiquitin ligase complex assembly The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane. go.json Dsc complex assembly http://purl.obolibrary.org/obo/GO_1990155 GO:1990150 biolink:CellularComponent VEGF-A complex A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase. go.json vascular endothelial growth factor A complex http://purl.obolibrary.org/obo/GO_1990150 GO:1990151 biolink:BiologicalProcess protein localization to cell tip A process in which a protein is transported to, or maintained in, a location at the cell tip. go.json protein localisation to cell tip http://purl.obolibrary.org/obo/GO_1990151 GO:1990167 biolink:BiologicalProcess protein K27-linked deubiquitination A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein. go.json http://purl.obolibrary.org/obo/GO_1990167 gocheck_do_not_annotate GO:1990168 biolink:BiologicalProcess protein K33-linked deubiquitination A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein. go.json http://purl.obolibrary.org/obo/GO_1990168 gocheck_do_not_annotate GO:1990169 biolink:BiologicalProcess stress response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus. go.json response to copper ion stress|response to copper toxicity|stress response to copper http://purl.obolibrary.org/obo/GO_1990169 GO:1990163 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990163 GO:1990164 biolink:BiologicalProcess obsolete histone H2A phosphorylation OBSOLETE. The modification of histone H2A by the addition of a phosphate group. go.json True http://purl.obolibrary.org/obo/GO_1990164 GO:1990165 biolink:MolecularActivity single-strand break-containing DNA binding Binding to damaged DNA containing single-strand breaks (SSBs). go.json SSB-containing DNA binding|single-strand break-containing damaged DNA binding http://purl.obolibrary.org/obo/GO_1990165 GO:1990166 biolink:BiologicalProcess protein localization to site of double-strand break Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred. go.json protein localisation to site of double-strand break|protein localization to double-strand break site|protein localization to site of DSB http://purl.obolibrary.org/obo/GO_1990166 GO:1990160 biolink:CellularComponent DnaB-DnaC-Rep-PriC complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. go.json DnaB-DnaC-Rep-PriC preprimosome|phi-X174-type preprimosome http://purl.obolibrary.org/obo/GO_1990160 GO:1990161 biolink:CellularComponent DnaB helicase complex A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair. go.json DnaB hexamer http://purl.obolibrary.org/obo/GO_1990161 GO:1990162 biolink:MolecularActivity histone H3K4 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein. go.json histone H3-K4 deacetylase activity|histone deacetylase activity (H3-K4 specific) http://purl.obolibrary.org/obo/GO_1990162 GO:1990178 biolink:CellularComponent HU-DNA complex A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure. go.json HU complex http://purl.obolibrary.org/obo/GO_1990178 GO:1990179 biolink:BiologicalProcess protein localization to actomyosin contractile ring A process in which a protein is transported to, or maintained at, the actomyosin contractile ring. go.json protein localisation to actomyosin contractile ring http://purl.obolibrary.org/obo/GO_1990179 GO:1990174 biolink:MolecularActivity phosphodiesterase decapping endonuclease activity Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA. go.json G(5')pppN pyrophosphatase activity http://purl.obolibrary.org/obo/GO_1990174 GO:1990175 biolink:MolecularActivity EH domain binding Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R. go.json http://purl.obolibrary.org/obo/GO_1990175 GO:1990176 biolink:CellularComponent MalFGK2 complex Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG. go.json MalF-MalG-MalK(2) complex|MalF-MalG-MalK-MalK complex|MalFGK(2) complex|maltose transport MalFGK2 complex|maltose transport complex, core subunit http://purl.obolibrary.org/obo/GO_1990176 GO:1990177 biolink:CellularComponent IHF-DNA complex A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid. go.json IHF complex|IHFa-IHFb-DNA complex http://purl.obolibrary.org/obo/GO_1990177 GO:1990170 biolink:BiologicalProcess stress response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus. go.json response to cadmium ion stress|response to cadmium toxicity|stress response to cadmium http://purl.obolibrary.org/obo/GO_1990170 GO:1990171 biolink:BiologicalProcess SCF complex disassembly in response to cadmium stress The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress. go.json http://purl.obolibrary.org/obo/GO_1990171 GO:1990172 biolink:BiologicalProcess G protein-coupled receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor. go.json G-protein coupled receptor catabolic process http://purl.obolibrary.org/obo/GO_1990172 GO:1990173 biolink:BiologicalProcess protein localization to nucleoplasm A process in which a protein is transported to, or maintained in, a location within the nucleoplasm. go.json nucleolus to nucleoplasm transport|protein localisation to nucleoplasm http://purl.obolibrary.org/obo/GO_1990173 GO:1990189 biolink:MolecularActivity peptide-serine-alpha-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide. go.json http://purl.obolibrary.org/obo/GO_1990189 GO:1990185 biolink:BiologicalProcess regulation of lymphatic vascular permeability Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid. go.json http://purl.obolibrary.org/obo/GO_1990185 GO:1990186 biolink:BiologicalProcess regulation of lymphatic vessel size Any process that modulates the size of lymphatic vessels. go.json regulation of collecting lymphatic vessel size http://purl.obolibrary.org/obo/GO_1990186 GO:1990187 biolink:BiologicalProcess obsolete protein localization to mRNA OBSOLETE. A process in which a protein is transported to, or maintained at mRNA. go.json protein localization to mRNA True http://purl.obolibrary.org/obo/GO_1990187 GO:1990188 biolink:MolecularActivity euchromatin binding Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin. go.json http://purl.obolibrary.org/obo/GO_1990188 GO:1990181 biolink:BiologicalProcess acetyl-CoA biosynthetic process from pantothenate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA. go.json acetyl-CoA anabolism from pantothenate|acetyl-CoA formation from pantothenate|acetyl-CoA synthesis from pantothenate http://purl.obolibrary.org/obo/GO_1990181 GO:1990182 biolink:BiologicalProcess exosomal secretion The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. go.json exosomal protein secretion|exosomal secretory pathway|extracellular vesicular exosome secretion|multi-vesicular body fusion with plasma membrane|secretion of exosome http://purl.obolibrary.org/obo/GO_1990182 GO:1990183 biolink:BiologicalProcess lymphatic vascular process in circulatory system A circulatory process that occurs at the level of the lymphatic vasculature. go.json http://purl.obolibrary.org/obo/GO_1990183 GO:1990184 biolink:CellularComponent amino acid transport complex A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1990184 GO:1990180 biolink:BiologicalProcess mitochondrial tRNA 3'-end processing The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. go.json tRNA 3' processing in mitochondria|tRNA 3' processing in mitochondrion|tRNA 3'-end processing in mitochondria http://purl.obolibrary.org/obo/GO_1990180 GO:1990112 biolink:CellularComponent RQC complex A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins. go.json ribosome quality control complex|ribosome-bound quality control complex http://purl.obolibrary.org/obo/GO_1990112 GO:1990113 biolink:BiologicalProcess RNA polymerase I assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex. go.json DNA-directed RNA polymerase I complex assembly|RNA Polymerase I complex assembly http://purl.obolibrary.org/obo/GO_1990113 GO:1990114 biolink:BiologicalProcess RNA polymerase II core complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex. go.json DNA-directed RNA polymerase II, core complex assembly|RNA Polymerase II assembly http://purl.obolibrary.org/obo/GO_1990114 GO:1990115 biolink:BiologicalProcess RNA polymerase III assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex. go.json DNA-directed RNA polymerase III complex assembly|RNA Polymerase III complex assembly http://purl.obolibrary.org/obo/GO_1990115 GO:1990110 biolink:BiologicalProcess callus formation The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate. go.json http://purl.obolibrary.org/obo/GO_1990110 GO:1990111 biolink:CellularComponent spermatoproteasome complex A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity. go.json http://purl.obolibrary.org/obo/GO_1990111 GO:0015498 biolink:MolecularActivity pantothenate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in). go.json http://purl.obolibrary.org/obo/GO_0015498 GO:0015499 biolink:MolecularActivity formate transmembrane transporter activity Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. RHEA:29679 go.json formate uptake permease activity|formate uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015499 GO:0015494 biolink:MolecularActivity aromatic amino acid:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in). go.json aromatic amino acid:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015494 GO:0015495 biolink:MolecularActivity gamma-aminobutyric acid:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). Reactome:R-HSA-428625 go.json 4-aminobutanoate:hydrogen symporter activity|4-aminobutanoate:proton symporter activity|4-aminobutyrate:hydrogen symporter activity|4-aminobutyrate:proton symporter activity|GABA:hydrogen symporter activity|GABA:proton symporter activity|gamma-aminobutyric acid permease activity|gamma-aminobutyric acid:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015495 GO:0015496 biolink:MolecularActivity putrescine:ornithine antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out). go.json putrescine-ornithine antiporter activity|putrescine/ornithine antiporter activity|putrescine:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015496 GO:0015497 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015497 GO:1990116 biolink:BiologicalProcess ribosome-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein. go.json RAD|ribosome-associated degradation|ribosome-associated ubiquitin-dependent protein breakdown|ribosome-associated ubiquitin-dependent protein catabolism|ribosome-associated ubiquitin-dependent protein degradation http://purl.obolibrary.org/obo/GO_1990116 GO:0015490 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015490 GO:1990117 biolink:BiologicalProcess B cell receptor apoptotic signaling pathway An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell. go.json B cell receptor extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway via B cell antigen receptor|extrinsic apoptotic signaling pathway via BCR http://purl.obolibrary.org/obo/GO_1990117 GO:0015491 biolink:MolecularActivity obsolete cation:cation antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). go.json True http://purl.obolibrary.org/obo/GO_0015491 GO:1990118 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990118 GO:0015492 biolink:MolecularActivity phenylalanine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in). go.json phenylalanine:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015492 GO:0015493 biolink:MolecularActivity lysine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in). go.json lysine:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015493 GO:1990119 biolink:MolecularActivity RNA helicase inhibitor activity Binds to and stops, prevents or reduces the activity of an RNA helicase. go.json ATP-dependent RNA helicase inhibitor activity http://purl.obolibrary.org/obo/GO_1990119 GO:1990123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990123 GO:1990124 biolink:CellularComponent messenger ribonucleoprotein complex A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules. go.json mRNA-protein complex|mRNP|mRNP complex|messenger ribonucleoprotein particle http://purl.obolibrary.org/obo/GO_1990124 GO:1990125 biolink:CellularComponent DiaA complex A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation. go.json DiaA homotetramer http://purl.obolibrary.org/obo/GO_1990125 GO:1990126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990126 GO:1990120 biolink:BiologicalProcess messenger ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex. go.json mRNA-protein complex assembly|mRNP assembly|mRNP complex assembly|messenger ribonucleoprotein assembly http://purl.obolibrary.org/obo/GO_1990120 GO:1990121 biolink:CellularComponent H-NS complex A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA. go.json DNA-binding protein H-NS complex|histone-like protein H-NS complex http://purl.obolibrary.org/obo/GO_1990121 GO:1990122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990122 GO:1990127 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered. go.json http://purl.obolibrary.org/obo/GO_1990127 GO:1990128 biolink:CellularComponent obsolete pre-primosome complex involved in replication initiation OBSOLETE. A protein-DNA complex involved in replication initiation at the origin of replication. go.json pre-primosome complex involved in replication initiation True http://purl.obolibrary.org/obo/GO_1990128 GO:1990129 biolink:CellularComponent obsolete pre-primosome complex involved in replication restart OBSOLETE. A protein-DNA complex involved in replication restart after a stalled replication fork has been repaired. go.json pre-primosome complex involved in replication restart True http://purl.obolibrary.org/obo/GO_1990129 GO:1990134 biolink:BiologicalProcess epithelial cell apoptotic process involved in palatal shelf morphogenesis An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf. go.json http://purl.obolibrary.org/obo/GO_1990134 GO:1990135 biolink:MolecularActivity flavonoid sulfotransferase activity Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative. go.json http://purl.obolibrary.org/obo/GO_1990135 GO:1990136 biolink:MolecularActivity linoleate 9S-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. EC:1.13.11.58|RHEA:30291 go.json 9-lipoxygenase activity|9S-lipoxygenase activity|linoleate 9-lipoxygenase activity|linoleate:oxygen 9S-oxidoreductase activity http://purl.obolibrary.org/obo/GO_1990136 GO:1990137 biolink:MolecularActivity plant seed peroxidase activity Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH. EC:1.11.2.3|MetaCyc:RXN-11819 go.json peroxygenase activity http://purl.obolibrary.org/obo/GO_1990137 GO:1990130 biolink:CellularComponent GATOR1 complex A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. go.json IML1 complex|SEACIT complex http://purl.obolibrary.org/obo/GO_1990130 GO:1990131 biolink:CellularComponent Gtr1-Gtr2 GTPase complex A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins. go.json http://purl.obolibrary.org/obo/GO_1990131 GO:1990132 biolink:BiologicalProcess obsolete release of misfolded protein from chaperone OBSOLETE. The release of misfolded proteins that are being held by the chaperone heat shock protein (Hsp) and targeting them for destruction by the Ub-proteasome machinery. go.json release of misfolded protein from chaperone True http://purl.obolibrary.org/obo/GO_1990132 GO:1990133 biolink:CellularComponent molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved. go.json http://purl.obolibrary.org/obo/GO_1990133 GO:0015476 biolink:MolecularActivity hemaglutinin autotransporter activity Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively. go.json http://purl.obolibrary.org/obo/GO_0015476 GO:0015477 biolink:MolecularActivity obsolete receptor porin activity OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane. go.json receptor porin activity True http://purl.obolibrary.org/obo/GO_0015477 GO:0015478 biolink:MolecularActivity oligosaccharide transporting porin activity Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. go.json raffinose porin http://purl.obolibrary.org/obo/GO_0015478 GO:0015479 biolink:MolecularActivity obsolete outer membrane exporter porin OBSOLETE. (Was not defined before being made obsolete). go.json outer membrane exporter porin True http://purl.obolibrary.org/obo/GO_0015479 GO:0015472 biolink:MolecularActivity obsolete fimbrium-specific chaperone activity OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function. go.json fimbrium-specific chaperone activity True http://purl.obolibrary.org/obo/GO_0015472 GO:0015473 biolink:MolecularActivity fimbrial usher porin activity A porin that acts in the assembly of fimbria together with fimbrial chaperone. go.json http://purl.obolibrary.org/obo/GO_0015473 GO:0015474 biolink:MolecularActivity autotransporter activity Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively. go.json http://purl.obolibrary.org/obo/GO_0015474 GO:0015475 biolink:MolecularActivity adhesin autotransporter activity Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively. go.json http://purl.obolibrary.org/obo/GO_0015475 GO:1990138 biolink:BiologicalProcess neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. go.json neurite extension|neuron process extension|neuron protrusion extension|neuronal cell projection extension http://purl.obolibrary.org/obo/GO_1990138 GO:1990139 biolink:BiologicalProcess protein localization to nuclear periphery A process in which a protein is transported to, or maintained in, a location within the nuclear periphery. go.json http://purl.obolibrary.org/obo/GO_1990139 GO:0015470 biolink:MolecularActivity obsolete bacteriocin activity OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor. go.json bacteriocin activity True http://purl.obolibrary.org/obo/GO_0015470 GO:0015471 biolink:MolecularActivity nucleoside-specific channel forming porin activity Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. go.json http://purl.obolibrary.org/obo/GO_0015471 GO:1990145 biolink:BiologicalProcess maintenance of translational fidelity Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template. go.json http://purl.obolibrary.org/obo/GO_1990145 GO:1990146 biolink:BiologicalProcess protein localization to rhabdomere A process in which a protein is transported to, or maintained in, a location within a rhabdomere. go.json http://purl.obolibrary.org/obo/GO_1990146 GO:1990147 biolink:MolecularActivity talin binding Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. go.json http://purl.obolibrary.org/obo/GO_1990147 GO:1990148 biolink:CellularComponent glutamate dehydrogenase complex A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies. go.json L-glutamate dehydrogenase complex|L-glutamate:NADP+ oxidoreductase (deaminating) complex|L-glutamic acid dehydrogenase complex|NAD(P)-glutamate dehydrogenase complex|NAD(P)H-dependent glutamate dehydrogenase complex|dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex|glutamate dehydrogenase (NADP+) complex|glutamic acid dehydrogenase complex|glutamic dehydrogenase complex http://purl.obolibrary.org/obo/GO_1990148 GO:1990141 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990141 GO:1990142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990142 GO:1990143 biolink:CellularComponent CoA-synthesizing protein complex A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway. go.json CoA-SPC|coenzyme A-synthesizing protein complex http://purl.obolibrary.org/obo/GO_1990143 GO:1990144 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to hypoxia The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered. go.json http://purl.obolibrary.org/obo/GO_1990144 GO:1990140 biolink:CellularComponent MPT synthase complex A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved. go.json molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex http://purl.obolibrary.org/obo/GO_1990140 GO:0015487 biolink:MolecularActivity melibiose:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in). go.json melibiose permease activity|melibiose:cation symporter activity|melibiose:monovalent cation symporter activity http://purl.obolibrary.org/obo/GO_0015487 GO:0015488 biolink:MolecularActivity glucuronide:cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in). go.json glucuronide:monovalent cation symporter activity|glucuronoside permease activity http://purl.obolibrary.org/obo/GO_0015488 GO:0015489 biolink:MolecularActivity putrescine transmembrane transporter activity Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. go.json http://purl.obolibrary.org/obo/GO_0015489 GO:0015483 biolink:MolecularActivity long-chain fatty acid transporting porin activity Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. TC:1.B.9.1.1 go.json http://purl.obolibrary.org/obo/GO_0015483 GO:0015484 biolink:MolecularActivity obsolete hemolysin activity OBSOLETE. Any substance that causes the lysis of red blood cells. go.json hemolysin activity True http://purl.obolibrary.org/obo/GO_0015484 GO:0015485 biolink:MolecularActivity cholesterol binding Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json http://purl.obolibrary.org/obo/GO_0015485 GO:0015486 biolink:MolecularActivity glycoside-pentoside-hexuronide:cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+. go.json http://purl.obolibrary.org/obo/GO_0015486 GO:1990149 biolink:BiologicalProcess obsolete COPI vesicle coating OBSOLETE. The addition of COPI proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. go.json COPI vesicle coating True http://purl.obolibrary.org/obo/GO_1990149 GO:0015480 biolink:MolecularActivity obsolete secretin (sensu Bacteria) OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm). go.json secretin (sensu Bacteria) True http://purl.obolibrary.org/obo/GO_0015480 GO:0015481 biolink:MolecularActivity maltose transporting porin activity Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. Wikipedia:Maltoporin go.json maltoporin http://purl.obolibrary.org/obo/GO_0015481 GO:0015482 biolink:MolecularActivity obsolete voltage-gated anion channel porin activity OBSOLETE. This term was not defined before being made obsolete. go.json voltage-dependent anion channel porin activity|voltage-gated anion channel porin activity True http://purl.obolibrary.org/obo/GO_0015482 GO:0015458 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015458 GO:0015459 biolink:MolecularActivity potassium channel regulator activity Binds to and modulates the activity of a potassium channel. go.json potassium channel gating activity http://purl.obolibrary.org/obo/GO_0015459 GO:0015454 biolink:MolecularActivity light-driven active monoatomic ion transmembrane transporter activity Active transport of an ion across a membrane, driven by light. TC:3.E go.json light absorption-driven transporter|light-driven active ion transmembrane transporter activity|light-driven active transmembrane transporter activity|light-driven pumps http://purl.obolibrary.org/obo/GO_0015454 GO:0015455 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015455 GO:0015456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015456 GO:0015457 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015457 GO:0015450 biolink:MolecularActivity protein-transporting ATPase activity Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Reactome:R-HSA-1222523 go.json P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein translocase activity http://purl.obolibrary.org/obo/GO_0015450 GO:0015451 biolink:MolecularActivity decarboxylation-driven active transmembrane transporter activity Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. EC:7.2.4.1|EC:7.2.4.2|EC:7.2.4.3|EC:7.2.4.4|EC:7.2.4.5|TC:3.B go.json decarboxylation-driven transporter http://purl.obolibrary.org/obo/GO_0015451 GO:0015452 biolink:MolecularActivity methyl transfer-driven active transmembrane transporter activity Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. TC:3.C go.json Methyltransfer-driven transporters http://purl.obolibrary.org/obo/GO_0015452 GO:0015453 biolink:MolecularActivity oxidoreduction-driven active transmembrane transporter activity Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. TC:3.D go.json oxidoreduction-driven transporter http://purl.obolibrary.org/obo/GO_0015453 GO:0015469 biolink:MolecularActivity obsolete channel-forming toxin activity OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell. go.json channel-forming toxin activity True http://purl.obolibrary.org/obo/GO_0015469 GO:0015465 biolink:MolecularActivity obsolete lysin activity OBSOLETE. An agent that can lyse cells. go.json lysin activity True http://purl.obolibrary.org/obo/GO_0015465 GO:0015466 biolink:MolecularActivity obsolete autolysin activity OBSOLETE. An agent that can lyse the cell in which it is synthesized. go.json autolysin activity True http://purl.obolibrary.org/obo/GO_0015466 GO:0015467 biolink:MolecularActivity G-protein activated inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. Reactome:R-HSA-1013020 go.json G protein activated inward rectifier potassium channel activity|G protein enhanced inward rectifier potassium channel activity|G-protein enhanced inward rectifier potassium channel activity|G-protein-activated inward rectifier potassium channel activity|G-protein-enhanced inward rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_0015467 GO:0015468 biolink:MolecularActivity obsolete colicin OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it. go.json colicin True http://purl.obolibrary.org/obo/GO_0015468 GO:0015461 biolink:MolecularActivity obsolete endosomal oligosaccharide transporter OBSOLETE. (Was not defined before being made obsolete). go.json endosomal oligosaccharide transporter True http://purl.obolibrary.org/obo/GO_0015461 GO:0015462 biolink:MolecularActivity ABC-type protein transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in). EC:7.4.2.5 go.json ABC-type protein transmembrane transporter activity|ATPase-coupled protein transmembrane transporter activity|pilin/fimbrilin exporter activity|protein ABC transporter|protein-transmembrane transporting ATPase activity|protein-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015462 GO:0015463 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015463 GO:0015464 biolink:MolecularActivity acetylcholine receptor activity Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0015464 GO:0015460 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015460 GO:0015436 biolink:MolecularActivity ABC-type capsular-polysaccharide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out). EC:7.6.2.12|MetaCyc:3.6.3.38-RXN go.json ATP phosphohydrolase (capsular-polysaccharide-exporting)|ATP-dependent capsular-polysaccharide transporter activity|ATPase-coupled capsular-polysaccharide transporter activity|capsular-polysaccharide ABC transporter|capsular-polysaccharide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015436 GO:0015437 biolink:MolecularActivity lipopolysaccharide floppase activity Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json ATP-dependent intramembrane lipopolysaccharide transporter activity|ATPase-coupled intramembrane lipopolysaccharide transporter activity|LPS-transporting ATPase activity|lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)|lipopolysaccharide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015437 GO:0015438 biolink:MolecularActivity ABC-type teichoic acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out). EC:7.5.2.4|MetaCyc:3.6.3.40-RXN go.json ABC-type teichoic-acid transporter|ATP-dependent teichoic acid transmembrane transporter activity|ATPase-coupled teichoic acid transmembrane transporter activity|teichoic acid transmembrane transporter activity|teichoic-acid ABC transporter|teichoic-acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015438 GO:0015439 biolink:MolecularActivity ABC-type heme transporter activity Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). EC:7.6.2.5|MetaCyc:3.6.3.41-RXN|MetaCyc:TRANS-RXN0-162|RHEA:19261|Reactome:R-HSA-1369065|Reactome:R-HSA-382560|Reactome:R-HSA-5683355|Reactome:R-HSA-917979 go.json ATP-dependent heme transmembrane transporter activity|ATPase-coupled heme transmembrane transporter activity|ATPase-coupled heme transporter activity|haem-transporting ATPase activity|heme ABC transporter|heme-transporting ATPase activity|protoheme IX ABC transporter activity http://purl.obolibrary.org/obo/GO_0015439 GO:0015432 biolink:MolecularActivity ABC-type bile acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate. RHEA:50048|Reactome:R-HSA-193362|Reactome:R-HSA-194153|Reactome:R-HSA-5678517|TC:3.A.1.207.2 go.json ATP-dependent bile acid transmembrane transporter activity|ATPase-coupled bile acid transmembrane transporter activity|bile acid porter activity|bile acid-exporting ATPase activity http://purl.obolibrary.org/obo/GO_0015432 GO:0015433 biolink:MolecularActivity ABC-type peptide antigen transporter activity Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. Reactome:R-HSA-1236949|Reactome:R-HSA-983144|TC:3.A.1.209.1 go.json ATP-dependent peptide antigen transmembrane transporter activity|ATPase-coupled peptide antigen transmembrane transporter activity|major histocompatibility peptide transporter activity|peptide antigen ABC transporter|peptide antigen transporter activity|peptide antigen-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015433 GO:0015434 biolink:MolecularActivity ABC-type cadmium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole). EC:7.2.2.2|MetaCyc:RXN-21035 go.json ATP-dependent cadmium transmembrane transporter activity|ATPase-coupled cadmium transmembrane transporter activity|cadmium ABC transporter|cadmium-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015434 GO:0015435 biolink:MolecularActivity obsolete ABC-type efflux permease activity OBSOLETE. (Was not defined before being made obsolete). go.json ABC-type efflux permease activity True http://purl.obolibrary.org/obo/GO_0015435 GO:0015430 biolink:MolecularActivity ABC-type glycerol-3-phosphate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in). EC:7.6.2.10|MetaCyc:ABC-34-RXN|RHEA:21668 go.json ABC-type glycerol 3-phosphate transporter|ATP-dependent glycerol-2-phosphate transmembrane transporter activity|ATPase-coupled glycerol-2-phosphate transmembrane transporter activity|ATPase-coupled glycerol-3-phosphate transmembrane transporter activity|glycerol phosphate-importing ATPase activity|glycerol-2-phosphate-transporting ATPase activity|glycerol-3-phosphate ABC transporter|glycerol-3-phosphate-transporting ATPase|glycerol-phosphate porter activity http://purl.obolibrary.org/obo/GO_0015430 GO:0015431 biolink:MolecularActivity ABC-type glutathione S-conjugate transporter activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). EC:7.6.2.3|RHEA:19121 go.json ATP-dependent glutathione S-conjugate export pump|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|GS-X pump|MRP1/GS-X pump|conjugate transporter activity|glutathione S-conjugate-exporting ATPase activity|glutathione S-conjugate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015431 GO:1990101 biolink:CellularComponent DnaA-oriC complex A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle. go.json DnaA-DNA complex http://purl.obolibrary.org/obo/GO_1990101 GO:1990102 biolink:CellularComponent DnaA-DiaA complex A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA. go.json DnaA-DiaA-DNA complex http://purl.obolibrary.org/obo/GO_1990102 GO:1990103 biolink:CellularComponent DnaA-HU complex A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC. go.json DnaA-HU-DNA complex http://purl.obolibrary.org/obo/GO_1990103 GO:1990104 biolink:CellularComponent DNA bending complex A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction. go.json histone-like DNA binding complex http://purl.obolibrary.org/obo/GO_1990104 GO:1990100 biolink:CellularComponent DnaB-DnaC complex A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC). go.json DnaB6-DnaC3 complex|DnaB6-DnaC6 complex|helicase-loading complex http://purl.obolibrary.org/obo/GO_1990100 GO:0015447 biolink:MolecularActivity obsolete type II protein secretor activity OBSOLETE. This term was not defined before being made obsolete. go.json type II protein secretor activity True http://purl.obolibrary.org/obo/GO_0015447 GO:0015448 biolink:MolecularActivity obsolete type III protein (virulence-related) secretor activity OBSOLETE. This term was not defined before being made obsolete. go.json type III protein (virulence-related) secretor activity True http://purl.obolibrary.org/obo/GO_0015448 GO:0015449 biolink:MolecularActivity obsolete type IV protein (DNA-protein) secretor activity OBSOLETE. This term was not defined before being made obsolete. go.json type IV protein (DNA-protein) secretor activity True http://purl.obolibrary.org/obo/GO_0015449 GO:0015443 biolink:MolecularActivity obsolete sodium-transporting two-sector ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). go.json sodium-transporting two-sector ATPase activity True http://purl.obolibrary.org/obo/GO_0015443 GO:0015444 biolink:MolecularActivity P-type magnesium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). EC:7.2.2.14|MetaCyc:TRANS-RXN-250|RHEA:10260 go.json ATP phosphohydrolase (Mg2+-importing)|Mg(2+)-importing ATPase activity|Mg2+-importing ATPase activity|magnesium importing ATPase activity|magnesium transmembrane transporter activity, phosphorylative mechanism|magnesium-translocating P-type ATPase activity http://purl.obolibrary.org/obo/GO_0015444 GO:0015445 biolink:MolecularActivity P-type silver transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out). EC:7.2.2.15|MetaCyc:3.6.3.53-RXN|RHEA:14733 go.json ATP phosphohydrolase (Ag+-exporting)|Ag+-exporting ATPase activity|silver exporting ATPase activity|silver transmembrane transporter activity, phosphorylative mechanism|silver-exporting ATPase activity http://purl.obolibrary.org/obo/GO_0015445 GO:0015446 biolink:MolecularActivity ATPase-coupled arsenite transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). EC:7.3.2.7|MetaCyc:3.6.3.16-RXN|RHEA:11348|TC:3.A.4.1.1 go.json arsenical pump-driving ATPase activity|arsenical resistance ATPase activity|arsenical resistance efflux pump|arsenite ABC transporter|arsenite transporting ATPase activity|arsenite-translocating ATPase activity|arsenite-transmembrane transporting ATPase activity|arsenite-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015446 GO:1990109 biolink:BiologicalProcess rejection of pollen from other species The recognition and rejection of pollen of one species by cells in the stigma of another species. go.json unilateral interspecific incompatibility http://purl.obolibrary.org/obo/GO_1990109 GO:0015440 biolink:MolecularActivity ABC-type peptide transporter activity Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria. EC:7.4.2.5|MetaCyc:3.6.3.43-RXN|RHEA:14429 go.json ATP-dependent peptide transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide ABC transporter|peptide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015440 GO:0015441 biolink:MolecularActivity ABC-type beta-glucan transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out). EC:7.5.2.3|MetaCyc:3.6.3.42-RXN|RHEA:18453 go.json ABC-type beta-glucan transporter|ATP-dependent beta-glucan transporter activity|ATPase-coupled beta-glucan transporter activity|beta-glucan ABC transporter|beta-glucan-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015441 GO:0015442 biolink:MolecularActivity obsolete hydrogen-/sodium-translocating ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out). go.json hydrogen-/sodium-translocating ATPase activity|proton-/sodium-translocating ATPase activity True http://purl.obolibrary.org/obo/GO_0015442 GO:1990105 biolink:BiologicalProcess obsolete regulation of voltage-gated potassium channel activity OBSOLETE. Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity. go.json regulation of voltage-gated potassium channel activity True http://purl.obolibrary.org/obo/GO_1990105 GO:1990106 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990106 GO:1990107 biolink:MolecularActivity thiazole synthase activity Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. RHEA:26297 go.json 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity http://purl.obolibrary.org/obo/GO_1990107 GO:1990108 biolink:BiologicalProcess protein linear deubiquitination A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein. go.json http://purl.obolibrary.org/obo/GO_1990108 gocheck_do_not_annotate GO:0039599 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039599 GO:0039593 biolink:BiologicalProcess peturbation by virus of host exit from mitosis A process in which a virus interferes with the host cell completing the M phase of the cell cycle. VZ:877 go.json inhibition of host mitotic exit by virus|suppression by virus of host exit from mitosis http://purl.obolibrary.org/obo/GO_0039593 GO:0039594 biolink:MolecularActivity endoribonuclease activity involved in viral induction of host mRNA catabolic process Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA. go.json http://purl.obolibrary.org/obo/GO_0039594 GO:0039591 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039591 GO:0039592 biolink:BiologicalProcess perturbation by virus of G2/M transition of host mitotic cell cycle A process in which a virus interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase. VZ:876 go.json host G2/M cell cycle arrest by virus|suppression by virus of G2/M transition of host mitotic cell cycle http://purl.obolibrary.org/obo/GO_0039592 GO:0039597 biolink:BiologicalProcess obsolete induction by virus of host endoribonuclease activity OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity. go.json viral induction of host RNAse activity True http://purl.obolibrary.org/obo/GO_0039597 GO:0039598 biolink:BiologicalProcess obsolete induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. go.json induction by virus of host nuclear poly(A)-dependent mRNA catabolic process|induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process|virus-mediated host mRNA decay by hyperadenylation True http://purl.obolibrary.org/obo/GO_0039598 GO:0039595 biolink:BiologicalProcess induction by virus of catabolism of host mRNA The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA). VZ:901 go.json induction by virus of host mRNA catabolic process|induction of host mRNA decay|promotion of host mRNA degradation|viral induction of host mRNA decay|virus-mediated mRNA decay http://purl.obolibrary.org/obo/GO_0039595 GO:0039596 biolink:BiologicalProcess obsolete modulation by virus of host protein dephosphorylation OBSOLETE. Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein. go.json True http://purl.obolibrary.org/obo/GO_0039596 GO:1990079 biolink:BiologicalProcess cartilage homeostasis A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function. go.json negative regulation of cartilage homeostasis|positive regulation of cartilage homeostasis|regulation of cartilage homeostasis http://purl.obolibrary.org/obo/GO_1990079 GO:1990075 biolink:CellularComponent periciliary membrane compartment A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis. go.json PCMC http://purl.obolibrary.org/obo/GO_1990075 GO:1990076 biolink:BiologicalProcess cell wall polysaccharide catabolic process involved in abscission Any cell wall polysaccharide catabolic process that is involved in abscission. go.json http://purl.obolibrary.org/obo/GO_1990076 GO:1990077 biolink:CellularComponent primosome complex Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. go.json primosome http://purl.obolibrary.org/obo/GO_1990077 GO:1990078 biolink:CellularComponent replication inhibiting complex A protein complex that inhibits multiple events of replication initiation during one replication cycle. go.json http://purl.obolibrary.org/obo/GO_1990078 GO:1990071 biolink:CellularComponent TRAPPII protein complex A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. go.json http://purl.obolibrary.org/obo/GO_1990071 GO:1990072 biolink:CellularComponent TRAPPIII protein complex A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins. go.json http://purl.obolibrary.org/obo/GO_1990072 GO:0039508 biolink:BiologicalProcess obsolete suppression by virus of host receptor activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor. go.json down-regulation by virus of host receptor activity|downregulation by virus of host receptor activity|inhibition by virus of host receptor activity|negative regulation by virus of host receptor activity|suppression by virus of host receptor function|viral inhibition of host receptor True http://purl.obolibrary.org/obo/GO_0039508 GO:1990073 biolink:CellularComponent perforation plate A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations). go.json http://purl.obolibrary.org/obo/GO_1990073 GO:0039509 biolink:BiologicalProcess obsolete suppression by virus of host pattern recognition receptor activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. go.json down regulation by virus of host pattern recognition receptor activity|down-regulation by virus of host pattern recognition receptor activity|inhibition by virus of host pattern recognition receptor activity|negative regulation by virus of host pattern recognition receptor activity|suppression by virus of host pattern recognition receptor function|viral inhibition of host pattern recognition receptor activity True http://purl.obolibrary.org/obo/GO_0039509 GO:1990074 biolink:BiologicalProcess polyuridylation-dependent mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA. go.json http://purl.obolibrary.org/obo/GO_1990074 GO:0015539 biolink:MolecularActivity hexuronate:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate. go.json hexuronate (glucuronate/galacturonate) porter activity|hexuronate porter activity|hexuronate:cation symporter activity http://purl.obolibrary.org/obo/GO_0015539 GO:1990070 biolink:CellularComponent TRAPPI protein complex A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast. go.json TRAPP core complex http://purl.obolibrary.org/obo/GO_1990070 GO:0039502 biolink:BiologicalProcess suppression by virus of host type I interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. VZ:883 go.json inhibition of host interferon signaling pathway by virus|negative regulation by virus of host type I interferon-mediated signaling pathway|suppression by virus of host type I IFN-mediated signaling pathway|suppression by virus of host type I interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0039502 GO:0015535 biolink:MolecularActivity fucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in). RHEA:29023 go.json fucose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015535 GO:0039503 biolink:BiologicalProcess suppression by virus of host innate immune response Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense. go.json inhibition of host innate immune response by virus|negative regulation by virus of host innate immune response|negative regulation by virus of host innate immunity|suppression by virus of host innate immunity http://purl.obolibrary.org/obo/GO_0039503 GO:0015536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015536 GO:0015537 biolink:MolecularActivity xanthosine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in). go.json xanthosine permease activity|xanthosine:hydrogen ion symporter activity http://purl.obolibrary.org/obo/GO_0015537 GO:0015538 biolink:MolecularActivity sialic acid:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in). RHEA:28987|Reactome:R-HSA-428585|Reactome:R-HSA-5624239 go.json sialic acid permease activity|sialic acid:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015538 GO:0039501 biolink:BiologicalProcess suppression by virus of host type I interferon production Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. VZ:875 go.json negative regulation by virus of host type I interferon production|suppression by virus of host interferon type I production|suppression by virus of host type I IFN production http://purl.obolibrary.org/obo/GO_0039501 GO:0039506 biolink:BiologicalProcess modulation by virus of host molecular function The process in which a virus effects a change in the function of a host protein via a direct interaction. go.json modification by virus of host protein function http://purl.obolibrary.org/obo/GO_0039506 GO:0015531 biolink:MolecularActivity citrate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in). RHEA:32123 go.json citrate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015531 GO:0015532 biolink:MolecularActivity alpha-ketoglutarate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in). go.json 2-oxoglutarate:hydrogen symporter activity|2-oxoglutarate:proton symporter activity|alpha-ketoglutarate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015532 GO:0039507 biolink:BiologicalProcess suppression by virus of host molecular function Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein. go.json down regulation by virus of host protein function|down-regulation by virus of host protein function|inhibition by virus of host protein function|inhibition of host protein function|negative regulation by virus of host molecular function|negative regulation by virus of host protein function http://purl.obolibrary.org/obo/GO_0039507 GO:0039504 biolink:BiologicalProcess suppression by virus of host adaptive immune response Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). go.json inhibition of host adaptive immune response by virus|negative regulation by virus of host adaptive immune response|negative regulation by virus of host adaptive immunity|suppression by virus of host acquired immune response http://purl.obolibrary.org/obo/GO_0039504 GO:0015533 biolink:MolecularActivity shikimate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in). go.json shikimate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015533 GO:0039505 biolink:BiologicalProcess suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex. VZ:820 go.json inhibition of host MHC class II molecule presentation by virus http://purl.obolibrary.org/obo/GO_0039505 GO:0015534 biolink:MolecularActivity obsolete proline/glycine/betaine:hydrogen/sodium symporter activity OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in). go.json proline/glycine/betaine:hydrogen/sodium symporter activity|proline/glycine/betaine:proton/sodium symporter True http://purl.obolibrary.org/obo/GO_0015534 GO:0015530 biolink:MolecularActivity shikimate transmembrane transporter activity Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids. go.json http://purl.obolibrary.org/obo/GO_0015530 GO:1990086 biolink:BiologicalProcess lens fiber cell apoptotic process Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_1990086 GO:1990087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990087 GO:1990088 biolink:MolecularActivity [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+. EC:2.1.1.246|MetaCyc:RXN-8096|RHEA:45208 go.json methanol-specific methylcobalamin: coenzyme M methyltransferase activity|methanol-specific methylcobalamin:CoM methyltransferase activity|methanol-specific methylcobalamin:coenzyme M methyltransferase activity|methylcobamide:CoM methyltransferase activity|methylcobamide:coenzyme M methyltransferase activity http://purl.obolibrary.org/obo/GO_1990088 GO:1990089 biolink:BiologicalProcess response to nerve growth factor A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. go.json response to nerve growth factor stimulus http://purl.obolibrary.org/obo/GO_1990089 GO:1990082 biolink:CellularComponent DnaA-L2 complex A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2. go.json http://purl.obolibrary.org/obo/GO_1990082 GO:1990083 biolink:CellularComponent DnaA-Hda complex A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda. go.json http://purl.obolibrary.org/obo/GO_1990083 GO:1990084 biolink:CellularComponent DnaA-Dps complex A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps. go.json http://purl.obolibrary.org/obo/GO_1990084 GO:1990085 biolink:CellularComponent Hda-beta clamp complex A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda. go.json Hda-DnaN complex|Hda-dpo3b complex http://purl.obolibrary.org/obo/GO_1990085 GO:1990080 biolink:MolecularActivity 2-phenylethylamine receptor activity Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity. go.json beta-phenylethylamine receptor activity http://purl.obolibrary.org/obo/GO_1990080 GO:1990081 biolink:MolecularActivity trimethylamine receptor activity Combining with the biogenic amine trimethylamine to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_1990081 GO:0015546 biolink:MolecularActivity sulfathiazole transmembrane transporter activity Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group. go.json bicyclomycin/sulfathiazole:hydrogen antiporter activity|sulphathiazole transporter activity http://purl.obolibrary.org/obo/GO_0015546 GO:0015547 biolink:MolecularActivity obsolete nalidixic acid transmembrane transporter activity OBSOLETE. Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. go.json carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity|nalidixic acid transporter activity True http://purl.obolibrary.org/obo/GO_0015547 GO:0015548 biolink:MolecularActivity organomercurial transmembrane transporter activity Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom. go.json carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity|organomercurial transporter activity http://purl.obolibrary.org/obo/GO_0015548 GO:0015549 biolink:MolecularActivity obsolete carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity OBSOLETE. Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. go.json CCCP transporter activity|carbonyl cyanide m-chlorophenylhydrazone transporter activity|carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity True http://purl.obolibrary.org/obo/GO_0015549 GO:0015542 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015542 GO:0015543 biolink:MolecularActivity obsolete lactose/glucose efflux transporter activity OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out). go.json lactose/glucose efflux transporter activity True http://purl.obolibrary.org/obo/GO_0015543 GO:0015544 biolink:MolecularActivity phenyl propionate uniporter activity Enables the transfer of phenyl propionate from one side of a membrane to the other. go.json phenyl propionate permease activity http://purl.obolibrary.org/obo/GO_0015544 GO:0015545 biolink:MolecularActivity bicyclomycin transmembrane transporter activity Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. go.json bicyclomycin transporter activity|bicyclomycin/sulfathiazole:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015545 GO:0015540 biolink:MolecularActivity 3-hydroxyphenyl propionate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in). go.json 3-hydroxyphenyl propionate porter activity|3-hydroxyphenyl propionate:hydrogen ion symporter activity http://purl.obolibrary.org/obo/GO_0015540 GO:0015541 biolink:MolecularActivity secondary active cyanate transmembrane transporter activity Enables the transfer of cyanate from one side of a membrane to the other. go.json cyanate porter activity http://purl.obolibrary.org/obo/GO_0015541 GO:1990097 biolink:CellularComponent SeqA-DNA complex A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle. go.json SeqA-dsDNA complex|SeqA-hemimethylated DNA complex|SeqA-hemimethylation dsDNA complex http://purl.obolibrary.org/obo/GO_1990097 GO:1990098 biolink:CellularComponent core primosome complex A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication. go.json core primosome http://purl.obolibrary.org/obo/GO_1990098 GO:1990099 biolink:CellularComponent pre-primosome complex Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component. go.json pre-priming complex|pre-primosome|pre-replication complex|preprimosome|preprimosome complex|prereplication complex http://purl.obolibrary.org/obo/GO_1990099 GO:1990093 biolink:BiologicalProcess obsolete negative regulation of N-methyl-D-aspartate receptor clustering OBSOLETE. The negative regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane. go.json negative regulation of N-methyl-D-aspartate receptor clustering|negative regulation of NMDA receptor clustering True http://purl.obolibrary.org/obo/GO_1990093 GO:1990094 biolink:BiologicalProcess obsolete positive regulation of N-methyl-D-aspartate receptor clustering OBSOLETE. The positive regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane. go.json positive regulation of N-methyl-D-aspartate receptor clustering|positive regulation of NMDA receptor clustering True http://purl.obolibrary.org/obo/GO_1990094 GO:1990095 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. go.json True http://purl.obolibrary.org/obo/GO_1990095 GO:1990096 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to superoxide OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. go.json True http://purl.obolibrary.org/obo/GO_1990096 GO:0015517 biolink:MolecularActivity galactose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in). go.json galactose:hydrogen symporter activity|lactose, galactose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015517 GO:1990090 biolink:BiologicalProcess cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. go.json cellular response to NGF http://purl.obolibrary.org/obo/GO_1990090 GO:0015518 biolink:MolecularActivity arabinose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in). go.json arabinose efflux permease activity|arabinose efflux transmembrane transporter activity|arabinose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015518 GO:1990091 biolink:BiologicalProcess sodium-dependent self proteolysis The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. go.json http://purl.obolibrary.org/obo/GO_1990091 GO:0015519 biolink:MolecularActivity D-xylose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in). go.json D-xylose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015519 GO:1990092 biolink:BiologicalProcess calcium-dependent self proteolysis The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. go.json http://purl.obolibrary.org/obo/GO_1990092 GO:0015513 biolink:MolecularActivity high-affinity secondary active nitrite transmembrane transporter activity Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json nitrite uptake permease activity http://purl.obolibrary.org/obo/GO_0015513 GO:0015514 biolink:MolecularActivity nitrite efflux transmembrane transporter activity Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane. go.json nitrite extrusion permease activity http://purl.obolibrary.org/obo/GO_0015514 GO:0015515 biolink:MolecularActivity citrate:succinate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out). go.json http://purl.obolibrary.org/obo/GO_0015515 GO:0015516 biolink:MolecularActivity tartrate:succinate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out). go.json http://purl.obolibrary.org/obo/GO_0015516 GO:0015510 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015510 GO:0015511 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015511 GO:0015512 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015512 GO:0015528 biolink:MolecularActivity lactose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in). go.json lactose, galactose:hydrogen symporter activity|lactose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015528 GO:0015529 biolink:MolecularActivity raffinose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in). go.json raffinose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015529 GO:0015524 biolink:MolecularActivity obsolete L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out). go.json L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity|L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity True http://purl.obolibrary.org/obo/GO_0015524 GO:0015525 biolink:MolecularActivity obsolete carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity OBSOLETE. (Was not defined before being made obsolete). go.json carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity|carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity True http://purl.obolibrary.org/obo/GO_0015525 GO:0015526 biolink:MolecularActivity hexose-phosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out). go.json http://purl.obolibrary.org/obo/GO_0015526 GO:0015527 biolink:MolecularActivity glycerol-phosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out). go.json http://purl.obolibrary.org/obo/GO_0015527 GO:0015520 biolink:MolecularActivity tetracycline:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). go.json tetracyclin:hydrogen antiporter activity|tetracyclin:proton antiporter activity|tetracycline:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0015520 GO:0015521 biolink:MolecularActivity obsolete bicyclomycin/sulfathiazole:hydrogen antiporter activity OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in). go.json bicyclomycin/sulfathiazole:hydrogen antiporter activity|bicyclomycin/sulfathiazole:proton antiporter activity|bicyclomycin/sulphathiazole:hydrogen antiporter activity True http://purl.obolibrary.org/obo/GO_0015521 GO:0015522 biolink:MolecularActivity obsolete hydrophobic uncoupler:proton antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS. go.json hydrophobic uncoupler:hydrogen antiporter activity True http://purl.obolibrary.org/obo/GO_0015522 GO:0015523 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015523 GO:1990035 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990035 GO:1990036 biolink:BiologicalProcess calcium ion import into sarcoplasmic reticulum The directed movement of calcium ions into a sarcoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_1990036 GO:1990037 biolink:CellularComponent Lewy body core The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments. NIF_Subcellular:sao6587439252 go.json http://purl.obolibrary.org/obo/GO_1990037 GO:1990038 biolink:CellularComponent Lewy body corona The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array. NIF_Subcellular:sao5764355747 go.json halo http://purl.obolibrary.org/obo/GO_1990038 GO:1990031 biolink:CellularComponent pinceau fiber Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment. NIF_Subcellular:sao109906988 go.json http://purl.obolibrary.org/obo/GO_1990031 GO:1990032 biolink:CellularComponent parallel fiber A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium. NIF_Subcellular:nlx_330 go.json http://purl.obolibrary.org/obo/GO_1990032 GO:1990033 biolink:CellularComponent dendritic branch point The part of a dendritic tree where it branches, giving rise to a dendritic branch. NIF_Subcellular:sao1348591767 go.json branch point of dendrite http://purl.obolibrary.org/obo/GO_1990033 GO:1990034 biolink:BiologicalProcess calcium ion export across plasma membrane The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json calcium ion efflux from cell|calcium ion export from cell http://purl.obolibrary.org/obo/GO_1990034 GO:1990030 biolink:CellularComponent pericellular basket Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name. NIF_Subcellular:sao413722576 go.json peri cellular basket|peri-cellular basket http://purl.obolibrary.org/obo/GO_1990030 GO:1990039 biolink:CellularComponent hypolemmal cisterna Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer. NIF_Subcellular:sao1634374950 go.json hypolemmal cisternae http://purl.obolibrary.org/obo/GO_1990039 GO:1990046 biolink:BiologicalProcess stress-induced mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis. go.json SIMH|mitochondrial fusion in response to stress|stress-induced mitochondrial hyperfusion http://purl.obolibrary.org/obo/GO_1990046 GO:1990047 biolink:CellularComponent spindle matrix A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis. go.json http://purl.obolibrary.org/obo/GO_1990047 GO:1990048 biolink:BiologicalProcess anterograde neuronal dense core vesicle transport The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. go.json anterograde dense core granule trafficking|anterograde dense core granule transport http://purl.obolibrary.org/obo/GO_1990048 goslim_synapse GO:1990049 biolink:BiologicalProcess retrograde neuronal dense core vesicle transport The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. go.json retrograde dense core granule trafficking|retrograde dense core granule transport http://purl.obolibrary.org/obo/GO_1990049 goslim_synapse GO:1990042 biolink:MolecularActivity glycerol dehydrogenase [NAD(P)+] activity Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced. go.json glycerol dehydrogenase activity, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_1990042 GO:1990043 biolink:MolecularActivity 5' deoxyribonuclease (pyrimidine dimer) activity Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate. go.json http://purl.obolibrary.org/obo/GO_1990043 GO:1990044 biolink:BiologicalProcess protein localization to lipid droplet A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet. go.json protein localisation to adiposome|protein localisation to lipid body|protein localisation to lipid droplet|protein localisation to lipid particle|protein localization to adiposome|protein localization to lipid body|protein localization to lipid particle http://purl.obolibrary.org/obo/GO_1990044 GO:1990045 biolink:BiologicalProcess sclerotium development The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions. go.json http://purl.obolibrary.org/obo/GO_1990045 GO:1990040 biolink:CellularComponent sub-surface cisterna Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane. NIF_Subcellular:sao128470897 go.json sub-surface cisternae http://purl.obolibrary.org/obo/GO_1990040 GO:1990041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990041 GO:0015506 biolink:MolecularActivity nucleoside:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in). go.json nucleoside permease activity|nucleoside:hydrogen ion symporter activity|nucleoside:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015506 GO:0015507 biolink:MolecularActivity obsolete hydroxy/aromatic amino acid permease activity OBSOLETE. Permease for hydroxy and aromatic amino acids. go.json hydroxy/aromatic amino acid permease activity True http://purl.obolibrary.org/obo/GO_0015507 GO:0015508 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015508 GO:0015509 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015509 GO:0015502 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015502 GO:0015503 biolink:MolecularActivity glutathione-regulated potassium exporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. go.json http://purl.obolibrary.org/obo/GO_0015503 GO:0015504 biolink:MolecularActivity cytosine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in). go.json cytosine permease activity|cytosine:hydrogen ion symporter activity http://purl.obolibrary.org/obo/GO_0015504 GO:0015505 biolink:MolecularActivity uracil:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in). go.json uracil permease activity|uracil:cation symporter activity http://purl.obolibrary.org/obo/GO_0015505 GO:0015500 biolink:MolecularActivity obsolete threonine/serine:sodium symporter activity OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in). go.json threonine/serine:sodium symporter activity True http://purl.obolibrary.org/obo/GO_0015500 GO:0015501 biolink:MolecularActivity glutamate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). RHEA:29031 go.json sodium/excitatory glutamate cotransporter activity|sodium/excitatory glutamate symporter activity http://purl.obolibrary.org/obo/GO_0015501 GO:1990057 biolink:BiologicalProcess obsolete cell cycle arrest in response to DNA damage stimulus OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of DNA damage from environmental insults or errors during metabolism. go.json cell cycle arrest in response to DNA damage stimulus True http://purl.obolibrary.org/obo/GO_1990057 GO:1990058 biolink:BiologicalProcess fruit replum development The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum. go.json http://purl.obolibrary.org/obo/GO_1990058 GO:1990059 biolink:BiologicalProcess fruit valve development The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces. go.json http://purl.obolibrary.org/obo/GO_1990059 GO:1990053 biolink:MolecularActivity DNA-5-methylcytosine glycosylase activity Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site. go.json http://purl.obolibrary.org/obo/GO_1990053 GO:1990054 biolink:BiologicalProcess response to temozolomide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus. go.json http://purl.obolibrary.org/obo/GO_1990054 gocheck_do_not_manually_annotate GO:1990055 biolink:MolecularActivity phenylacetaldehyde synthase activity Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2. EC:4.1.1.109|RHEA:55532 go.json aromatic aldehyde synthase http://purl.obolibrary.org/obo/GO_1990055 GO:1990056 biolink:MolecularActivity obsolete protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process OBSOLETE. Catalysis of the phosphorylation of an amino acid residue in a substrate protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP, thereby targeting the substrate to the proteasomal ubiquitin mediated protein catabolic process. go.json protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process True http://purl.obolibrary.org/obo/GO_1990056 GO:1990050 biolink:MolecularActivity phosphatidic acid transfer activity Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. go.json intermembrane PA transfer activity|intermembrane phosphatidic acid transfer activity|phosphatidic acid carrier activity|phosphatidic acid transporter activity http://purl.obolibrary.org/obo/GO_1990050 GO:1990051 biolink:BiologicalProcess activation of protein kinase C activity Any process that initiates the activity of the inactive enzyme protein kinase C. go.json PKC activation|protein kinase C activation http://purl.obolibrary.org/obo/GO_1990051 gocheck_do_not_annotate GO:1990052 biolink:BiologicalProcess ER to chloroplast lipid transport The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast. go.json ER to chloroplast lipid trafficking|endoplasmic reticulum to chloroplast lipid transport http://purl.obolibrary.org/obo/GO_1990052 GO:1990068 biolink:BiologicalProcess seed dehydration The seed development process whose outcome is the drying of a maturing seed. go.json http://purl.obolibrary.org/obo/GO_1990068 GO:1990069 biolink:BiologicalProcess stomatal opening The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. go.json http://purl.obolibrary.org/obo/GO_1990069 GO:1990064 biolink:BiologicalProcess ground tissue pattern formation The regionalization process that gives rise to the patterning of the ground tissue. go.json ground tissue patterning http://purl.obolibrary.org/obo/GO_1990064 GO:1990065 biolink:CellularComponent Dxr protein complex A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). go.json 1-deoxy-D-xylulose 5-phosphate reductoisomerase complex http://purl.obolibrary.org/obo/GO_1990065 GO:1990066 biolink:BiologicalProcess energy quenching The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence. go.json http://purl.obolibrary.org/obo/GO_1990066 GO:1990067 biolink:BiologicalProcess intrachromosomal DNA recombination The process of DNA recombination occurring within a single chromosome. go.json intrastrand DNA recombination http://purl.obolibrary.org/obo/GO_1990067 GO:1990060 biolink:CellularComponent maltose transport complex Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. go.json maltose ABC transporter complex|maltose ATP-binding cassette transporter complex http://purl.obolibrary.org/obo/GO_1990060 GO:1990061 biolink:CellularComponent bacterial degradosome The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase. go.json http://purl.obolibrary.org/obo/GO_1990061 GO:1990062 biolink:CellularComponent RPAP3/R2TP/prefoldin-like complex A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. go.json R2TP/prefoldin-like complex http://purl.obolibrary.org/obo/GO_1990062 GO:1990063 biolink:CellularComponent Bam protein complex Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. go.json OMP complex http://purl.obolibrary.org/obo/GO_1990063 GO:0039588 biolink:BiologicalProcess suppression by virus of host antigen processing and presentation Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex. VZ:815 go.json inhibition of host proteasome antigen processing by virus http://purl.obolibrary.org/obo/GO_0039588 GO:0039589 biolink:BiologicalProcess obsolete suppression by virus of host TAP complex OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response. VZ:817 go.json inhibition of host TAP by virus True http://purl.obolibrary.org/obo/GO_0039589 GO:0039582 biolink:BiologicalProcess obsolete suppression by virus of host PKR activity by positive regulation of PKR nuclear localization OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha). go.json suppression by virus of host PKR activity by nuclear sequestration of PKR|suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus|suppression by virus of host PKR activity by sequestering of PKR in nucleus True http://purl.obolibrary.org/obo/GO_0039582 GO:0039583 biolink:BiologicalProcess obsolete suppression by virus of host PKR activity by positive regulation of PKR catabolic process OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes. go.json downregulation of PKR by degradation through proteosome|promotion by virus of proteosome-dependent PKR degradation True http://purl.obolibrary.org/obo/GO_0039583 GO:0039580 biolink:BiologicalProcess suppression by virus of host PKR signaling Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response. go.json suppression by virus of host EIF2AK2 activity|suppression by virus of host PKR activity http://purl.obolibrary.org/obo/GO_0039580 GO:0039581 biolink:BiologicalProcess obsolete suppression by virus of host PKR activity via double-stranded RNA binding OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by binding to double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding. go.json suppression by virus of host PKR activity by binding to dsRNA True http://purl.obolibrary.org/obo/GO_0039581 GO:0039586 biolink:BiologicalProcess obsolete modulation by virus of host PP1 activity OBSOLETE. The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response. VZ:803 go.json modulation of host PP1 activity by virus|regulation by virus of host PP1 activity True http://purl.obolibrary.org/obo/GO_0039586 GO:0039587 biolink:BiologicalProcess suppression by virus of host tetherin activity Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects. go.json inhibition of host BST2/Tetherin by virus http://purl.obolibrary.org/obo/GO_0039587 GO:0039584 biolink:BiologicalProcess obsolete suppression by virus of host protein kinase activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity. go.json True http://purl.obolibrary.org/obo/GO_0039584 GO:0039585 biolink:BiologicalProcess PKR-mediated signaling A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation. go.json EIF2AK2 signal transduction|EIF2AK2/PRK signaling|PKR signal transduction|PKR signaling pathway|signaling through PKR http://purl.obolibrary.org/obo/GO_0039585 GO:1990002 biolink:MolecularActivity methylglyoxal reductase (NADPH-dependent, acetol producing) Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH. MetaCyc:RXN0-4281|RHEA:27986 go.json http://purl.obolibrary.org/obo/GO_1990002 GO:1990003 biolink:MolecularActivity IDP phosphatase activity Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate. EC:3.6.1.64|RHEA:35207|Reactome:R-HSA-2509816 go.json IDP diphosphatase activity|IDPase activity|inosine diphosphatase activity|inosine-diphosphatase activity http://purl.obolibrary.org/obo/GO_1990003 GO:1990004 biolink:MolecularActivity obsolete XDP phosphatase activity OBSOLETE. Catalysis of the reaction: XDP + H2O = XMP + phosphate. go.json True http://purl.obolibrary.org/obo/GO_1990004 GO:1990005 biolink:CellularComponent granular vesicle A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells. NIF_Subcellular:sao478230652 go.json http://purl.obolibrary.org/obo/GO_1990005 GO:1990000 biolink:BiologicalProcess amyloid fibril formation The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. go.json amyloid fibril assembly|amyloid structure assembly|amyloid structure formation http://purl.obolibrary.org/obo/GO_1990000 GO:1990001 biolink:BiologicalProcess inhibition of cysteine-type endopeptidase activity involved in apoptotic process Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process. go.json http://purl.obolibrary.org/obo/GO_1990001 gocheck_do_not_annotate GO:0039579 biolink:BiologicalProcess suppression by virus of host ISG15-protein conjugation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives. https://github.com/geneontology/go-ontology/issues/25581 go.json suppression by virus of host ISG15 activity http://purl.obolibrary.org/obo/GO_0039579 GO:0039577 biolink:BiologicalProcess obsolete suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1. go.json True http://purl.obolibrary.org/obo/GO_0039577 GO:0039578 biolink:BiologicalProcess obsolete suppression by virus of host JAK1 activity via JAK1 binding OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive. go.json True http://purl.obolibrary.org/obo/GO_0039578 GO:0039571 biolink:BiologicalProcess obsolete suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation. go.json inhibition by virus of tyrosine phosphorylation of STAT1 True http://purl.obolibrary.org/obo/GO_0039571 GO:0039572 biolink:BiologicalProcess obsolete suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation. go.json inhibition by virus of tyrosine phosphorylation of STAT2 True http://purl.obolibrary.org/obo/GO_0039572 GO:0039570 biolink:BiologicalProcess obsolete suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes. go.json cytoplasmic sequestering of STAT2|cytoplasmic sequestration of STAT2 True http://purl.obolibrary.org/obo/GO_0039570 GO:1990006 biolink:CellularComponent amorphous vesicle A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway. NIF_Subcellular:sao1531915298 go.json http://purl.obolibrary.org/obo/GO_1990006 GO:0039575 biolink:BiologicalProcess obsolete suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2. go.json inhibition by virus of host TYK2 activation|inhibition by virus of host TYK2 phosphorylation True http://purl.obolibrary.org/obo/GO_0039575 GO:0039576 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity Any process in which interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1). VZ:784 go.json inhibition of host JAK activity by virus|negative regulation by virus of host JAK|negative regulation by virus of tyrosine phosphorylation of host STAT protein|suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity|suppression by virus of host JAK1 activity|suppression by virus of host janus kinase 1 activity|suppression by virus of tyrosine phosphorylation of host STAT protein|viral inhibition of tyrosine phosphorylation of host STAT protein http://purl.obolibrary.org/obo/GO_0039576 GO:1990007 biolink:CellularComponent membrane stack A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures. NIF_Subcellular:sao2114874506 go.json http://purl.obolibrary.org/obo/GO_1990007 GO:1990008 biolink:CellularComponent neurosecretory vesicle A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus. NIF_Subcellular:sao2031592629 go.json http://purl.obolibrary.org/obo/GO_1990008 GO:0039573 biolink:BiologicalProcess suppression by virus of host complement activation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase. VZ:811 go.json inhibition of host complement activation by virus|inhibition of host complement cascade by virus|inhibition of host complement factors by virus http://purl.obolibrary.org/obo/GO_0039573 GO:0039574 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits. go.json suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity|suppression by virus of host TYK2 activity|suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity http://purl.obolibrary.org/obo/GO_0039574 GO:1990009 biolink:BiologicalProcess retinal cell apoptotic process Any apoptotic process in a retinal cell. go.json induction of retinal programmed cell death http://purl.obolibrary.org/obo/GO_1990009 GO:1990013 biolink:CellularComponent presynaptic grid A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane. NIF_Subcellular:sao1730664005 go.json pre-synaptic grid http://purl.obolibrary.org/obo/GO_1990013 GO:1990014 biolink:CellularComponent orthogonal array Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels). NIF_Subcellular:sao1747012216 go.json OAP|orthogonal array of particles|square array http://purl.obolibrary.org/obo/GO_1990014 GO:1990015 biolink:CellularComponent ensheathing process A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma. NIF_Subcellular:sao1376748732 go.json ensheathing process of Schwann cell http://purl.obolibrary.org/obo/GO_1990015 GO:1990016 biolink:CellularComponent neck portion of tanycyte Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. NIF_Subcellular:sao901230115 go.json neck portion http://purl.obolibrary.org/obo/GO_1990016 GO:1990010 biolink:BiologicalProcess compound eye retinal cell apoptotic process Any apoptotic process in a compound eye retinal cell. go.json http://purl.obolibrary.org/obo/GO_1990010 GO:1990011 biolink:CellularComponent laminated body Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus. NIF_Subcellular:sao506721981 go.json laminated inclusion body http://purl.obolibrary.org/obo/GO_1990011 GO:1990012 biolink:CellularComponent complex laminated body A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint. NIF_Subcellular:nlx_151681 go.json CLB http://purl.obolibrary.org/obo/GO_1990012 GO:0039568 biolink:BiologicalProcess obsolete suppression by virus of host STAT1 activity by inhibition of DNA binding OBSOLETE. Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus. go.json inhibition of DNA binding of STAT1|suppression by virus of host STAT1 activity by negative regulation of DNA binding True http://purl.obolibrary.org/obo/GO_0039568 GO:0039569 biolink:BiologicalProcess obsolete suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome. go.json promotion by virus of proteosome-dependent STAT2 degradation|suppression by virus of host STAT2 activity by positive promotion of STAT2 proteasome-mediated degradation|targeting STAT2 for proteasome-mediated degradation True http://purl.obolibrary.org/obo/GO_0039569 GO:0039566 biolink:BiologicalProcess obsolete suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1 OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation. go.json suppression by virus of host STAT1 activity by peptidyl-tyrosine dephosphorylation of STAT1|viral tyrosine phosphatase activity involved in suppression of host STAT1 True http://purl.obolibrary.org/obo/GO_0039566 GO:0039567 biolink:BiologicalProcess obsolete suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes. go.json cytoplasmic sequestration of STAT1|suppression by virus of host STAT1 activity by cytoplasmic sequestering of STAT1 True http://purl.obolibrary.org/obo/GO_0039567 GO:0015597 biolink:MolecularActivity obsolete histidine/arginine/lysine/ornithine porter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). go.json histidine/arginine/lysine/ornithine porter activity True http://purl.obolibrary.org/obo/GO_0015597 GO:0015598 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015598 GO:0015599 biolink:MolecularActivity ATPase-coupled L-glutamine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in). EC:7.4.2.1|MetaCyc:ABC-12-RXN go.json ATPase-coupled glutamine transmembrane transporter activity|glutamine porter activity|glutamine-importing ATPase activity http://purl.obolibrary.org/obo/GO_0015599 GO:0039560 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes. go.json inhibition of host IRF9 by virus|inhibition of host interferon regulatory factor-9 by virus|suppression by virus of host IRF9 activity|suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity|suppression by virus of host interferon regulatory factor 9 activity http://purl.obolibrary.org/obo/GO_0039560 GO:0015593 biolink:MolecularActivity allose transmembrane transporter activity Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. go.json http://purl.obolibrary.org/obo/GO_0015593 GO:0015594 biolink:MolecularActivity ABC-type putrescine transporter activity Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in). EC:7.6.2.16|RHEA:29995 go.json ATPase-coupled putrescine transmembrane transporter activity|putrescine porter activity|putrescine-importing ATPase activity http://purl.obolibrary.org/obo/GO_0015594 GO:0039561 biolink:BiologicalProcess obsolete suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism. go.json suppression by virus of host IRF9 activity by nuclear localization of IRF9|suppression of interferon signaling by nuclear accumulation of IRF9 True http://purl.obolibrary.org/obo/GO_0039561 GO:0015595 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015595 GO:0015596 biolink:MolecularActivity obsolete glycine betaine/proline porter activity OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in). go.json glycine betaine/proline porter activity True http://purl.obolibrary.org/obo/GO_0015596 GO:0039564 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2). go.json inhibition by virus of host STAT2 activity|inhibition of host STAT2 by virus|suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity|suppression by virus of host STAT2 activity http://purl.obolibrary.org/obo/GO_0039564 GO:1990017 biolink:CellularComponent somatic portion of tanycyte Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. NIF_Subcellular:sao401910342 go.json somatic portion http://purl.obolibrary.org/obo/GO_1990017 GO:1990018 biolink:CellularComponent tail portion of tanycyte Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell. NIF_Subcellular:sao1749953771 go.json tail portion http://purl.obolibrary.org/obo/GO_1990018 GO:0039565 biolink:BiologicalProcess obsolete suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome. go.json promotion by virus of proteosome-dependent STAT1 degradation|suppression by virus of host STAT1 activity by positive promotion of STAT1 proteasome-mediated degradation|targeting STAT1 for proteasome-mediated degradation True http://purl.obolibrary.org/obo/GO_0039565 GO:0015590 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015590 GO:0039562 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade via inhibition of STAT activity Any process in which a virus interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes. go.json inhibition by virus of host STAT activity|suppression by virus of host JAK-STAT cascade via inhibition of STAT activity|suppression by virus of host STAT activity|suppression by virus of host signal transducer and activator of transcription activity http://purl.obolibrary.org/obo/GO_0039562 GO:0015591 biolink:MolecularActivity D-ribose transmembrane transporter activity Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. go.json http://purl.obolibrary.org/obo/GO_0015591 GO:1990019 biolink:BiologicalProcess protein storage vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole. go.json http://purl.obolibrary.org/obo/GO_1990019 GO:0039563 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1). go.json inhibition by virus of host STAT1 activity|inhibition of host STAT1 by virus|suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity|suppression by virus of host STAT1 activity http://purl.obolibrary.org/obo/GO_0039563 GO:0015592 biolink:MolecularActivity methylgalactoside transmembrane transporter activity Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. go.json galactose/glucose (methylgalactoside) porter activity http://purl.obolibrary.org/obo/GO_0015592 GO:1990024 biolink:CellularComponent C bouton Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons. NIF_Subcellular:nlx_subcell_100208 go.json http://purl.obolibrary.org/obo/GO_1990024 GO:1990025 biolink:CellularComponent F bouton Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles. NIF_Subcellular:nlx_subcell_100206 go.json http://purl.obolibrary.org/obo/GO_1990025 GO:1990026 biolink:CellularComponent hippocampal mossy fiber expansion Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites. NIF_Subcellular:nlx_subcell_1005002 go.json dentate gyrus granule cell axonal bouton|dentate gyrus mossy fiber expansion|mossy fiber expansion http://purl.obolibrary.org/obo/GO_1990026 GO:1990027 biolink:CellularComponent S bouton Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles. NIF_Subcellular:nlx_subcell_100207 go.json http://purl.obolibrary.org/obo/GO_1990027 GO:1990020 biolink:CellularComponent recurrent axon collateral Axon collateral that ramifies in the area of the soma of the cell of origin. NIF_Subcellular:sao1642494436 go.json recurrent collateral http://purl.obolibrary.org/obo/GO_1990020 GO:1990021 biolink:CellularComponent Schaffer axon collateral Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1. NIF_Subcellular:nlx_subcell_20090511 go.json Schaffer collateral http://purl.obolibrary.org/obo/GO_1990021 GO:1990022 biolink:BiologicalProcess obsolete RNA polymerase III complex import into nucleus OBSOLETE. The directed movement of an RNA polymerase III complex from the cytoplasm to the nucleus. go.json DNA-directed RNA polymerase III complex import into nucleus|DNA-directed RNA polymerase III complex localization to nucleus|RNA polymerase III complex import into nucleus|RNA polymerase III complex localisation to nucleus|RNA polymerase III complex localization to nucleus True http://purl.obolibrary.org/obo/GO_1990022 GO:1990023 biolink:CellularComponent mitotic spindle midzone The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. go.json http://purl.obolibrary.org/obo/GO_1990023 GO:0039557 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. go.json inhibition of host IRF7 by virus|inhibition of host interferon regulatory factor-7 by virus|suppression by virus of host IRF7 activity|suppression by virus of host interferon regulatory factor 7 activity http://purl.obolibrary.org/obo/GO_0039557 GO:0039558 biolink:BiologicalProcess obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity. go.json promotion of IRF-7 SUMOylation|suppression by virus of host interferon regulatory factor-7 activity by positive regulation of IRF7 sumoylation True http://purl.obolibrary.org/obo/GO_0039558 GO:0039555 biolink:BiologicalProcess obsolete suppression by virus of host MDA-5 activity via MDA-5 binding OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by binding to MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector. go.json suppression by virus of host MDA5 activity by MDA-5 binding True http://purl.obolibrary.org/obo/GO_0039555 GO:0039556 biolink:MolecularActivity MDA-5 binding Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA. go.json MDA5 binding http://purl.obolibrary.org/obo/GO_0039556 GO:0039559 biolink:BiologicalProcess obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome. go.json promotion by virus of proteosome-dependent IRF7 degradation True http://purl.obolibrary.org/obo/GO_0039559 GO:0039550 biolink:BiologicalProcess obsolete suppression by virus of host IRF3 activity by inhibition of DNA binding OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites. go.json inhibition by virus of host IRF3-DNA binding True http://purl.obolibrary.org/obo/GO_0039550 GO:0039553 biolink:BiologicalProcess obsolete suppression by virus of host chemokine activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity. VZ:813 go.json down-regulation by virus of host chemokine activity|downregulation by virus of host chemokine activity|inhibition by virus of host chemokine activity|inhibition of host chemokines by virus|negative regulation by virus of host chemokine activity True http://purl.obolibrary.org/obo/GO_0039553 GO:1990028 biolink:MolecularActivity intermediate voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded. go.json R-type calcium channel http://purl.obolibrary.org/obo/GO_1990028 GO:1990029 biolink:BiologicalProcess vasomotion The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm. go.json http://purl.obolibrary.org/obo/GO_1990029 GO:0039554 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. go.json Inhibition of host MDA5 by virus|inhibition by virus of host MDA-5 signaling|inhibition of host IFIH1/MDA5 by virus|suppression by virus of host IFIH1 signaling pathway|suppression by virus of host MDA-5 activity|suppression by virus of host MDA-5 signaling pathway|suppression by virus of host MDA-5 signalling pathway http://purl.obolibrary.org/obo/GO_0039554 GO:0039551 biolink:BiologicalProcess obsolete suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome. go.json promotion by virus of proteosome-dependent IRF3 degradation True http://purl.obolibrary.org/obo/GO_0039551 GO:0039552 biolink:MolecularActivity RIG-I binding Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA. go.json DDX58 binding|DDX58/RIG-I binding http://purl.obolibrary.org/obo/GO_0039552 GO:0039546 biolink:BiologicalProcess obsolete suppression by virus of host MAVS activity by MAVS proteolysis OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling. go.json viral protease cleavage of MAVS True http://purl.obolibrary.org/obo/GO_0039546 GO:0015579 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015579 GO:0039547 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039547 GO:0039544 biolink:BiologicalProcess obsolete suppression by virus of host RIG-I activity by RIG-I proteolysis OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction. go.json cleavage of RIG-I by viral proteinase|inhibition by virus of host RIG-I activity by RIG-I proteolysis True http://purl.obolibrary.org/obo/GO_0039544 GO:0039545 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses. go.json inhibition of host MAVS by virus|suppression by virus of host MAVS activity|suppression by virus of host mitochondrial antiviral-signaling protein http://purl.obolibrary.org/obo/GO_0039545 GO:0015575 biolink:MolecularActivity mannitol transmembrane transporter activity Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. go.json mannitol permease activity http://purl.obolibrary.org/obo/GO_0015575 GO:0015576 biolink:MolecularActivity sorbitol transmembrane transporter activity Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. go.json glucitol permease activity|glucitol transporter activity|sorbitol permease activity http://purl.obolibrary.org/obo/GO_0015576 GO:0039548 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. go.json inhibition of IRF3-dependent antiviral response|inhibition of host IRF3 by virus|suppression by virus of host IRF3 activity|suppression by virus of host interferon regulatory factor 3 http://purl.obolibrary.org/obo/GO_0039548 GO:0015577 biolink:MolecularActivity galactitol transmembrane transporter activity Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. RHEA:33143 go.json galactitol permease activity http://purl.obolibrary.org/obo/GO_0015577 GO:0039549 biolink:BiologicalProcess obsolete suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes. go.json inhibition of phosphorylation-induced activation of host IRF3|inhibition of virus-induced IRF-3 phosphorylation True http://purl.obolibrary.org/obo/GO_0039549 GO:0015578 biolink:MolecularActivity mannose transmembrane transporter activity Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. go.json mannose permease activity http://purl.obolibrary.org/obo/GO_0015578 GO:0015571 biolink:MolecularActivity N-acetylgalactosamine transmembrane transporter activity Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. go.json N-acetylgalactosamine permease activity http://purl.obolibrary.org/obo/GO_0015571 GO:0015572 biolink:MolecularActivity N-acetylglucosamine transmembrane transporter activity Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. go.json D-GlcNAc transmembrane transporter activity|N-Acetyl-D-glucosamine permease|N-acetyl-D-glucosamine transmembrane transporter activity|N-acetylchitosamine transmembrane transporter activity|N-acetylglucosamine permease activity http://purl.obolibrary.org/obo/GO_0015572 GO:0015573 biolink:MolecularActivity beta-glucoside transmembrane transporter activity Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. go.json beta-glucoside permease activity http://purl.obolibrary.org/obo/GO_0015573 GO:0015574 biolink:MolecularActivity trehalose transmembrane transporter activity Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens. RHEA:17629 go.json trehalose permease activity http://purl.obolibrary.org/obo/GO_0015574 GO:0039542 biolink:BiologicalProcess obsolete suppression by virus of host RIG-I K63-linked ubiquitination OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity. go.json inhibition by virus of TRIM25-mediated ubiquitination of host RIG-I|inhibition by virus of host DDX58 K63-linked ubiquitination|inhibition by virus of host RIG-I activity by inhibition of RIG-I ubiquitination True http://purl.obolibrary.org/obo/GO_0039542 GO:0039543 biolink:BiologicalProcess obsolete suppression by virus of host RIG-I activity by viral RNA 5' processing OBSOLETE. The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition. go.json suppression by virus of host RIG-I activity by inhibition of RNA binding True http://purl.obolibrary.org/obo/GO_0039543 GO:0039540 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. go.json inhibition by virus of host DDX58 activity|inhibition by virus of host RIG-I|inhibition by virus of host RIG-I signaling|inhibition of host DDX58/RIG-I by virus|suppression by virus of host DDX58 signaling pathway|suppression by virus of host RIG-I activity|suppression by virus of host RIG-I signaling pathway|suppression by virus of host RIG-I signalling pathway http://purl.obolibrary.org/obo/GO_0039540 GO:0039541 biolink:BiologicalProcess obsolete suppression by virus of host RIG-I via RIG-I binding OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by binding to RIG-I itself. go.json inhibition by virus of host DDX58:MAVS binding True http://purl.obolibrary.org/obo/GO_0039541 GO:0015570 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015570 GO:0039535 biolink:BiologicalProcess regulation of RIG-I signaling pathway Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway. go.json regulation of DDX58 signaling pathway|regulation of RIG-I signalling pathway|regulation of retinoic acid inducible gene I signaling pathway http://purl.obolibrary.org/obo/GO_0039535 GO:0039536 biolink:BiologicalProcess negative regulation of RIG-I signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway. go.json negative regulation of DDX58 signaling pathway|negative regulation of RIG-I signalling pathway|negative regulation of retinoic acid inducible gene I signaling pathway http://purl.obolibrary.org/obo/GO_0039536 GO:0039533 biolink:BiologicalProcess regulation of MDA-5 signaling pathway Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. go.json regulation of IFIH1 signaling pathway|regulation of MDA-5 signalling pathway|regulation of MDA5 signaling pathway|regulation of melanoma differentiation-associated gene 5 signaling pathway http://purl.obolibrary.org/obo/GO_0039533 GO:0039534 biolink:BiologicalProcess negative regulation of MDA-5 signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway. go.json negative regulation of IFIH1 signaling pathway|negative regulation of MDA-5 signalling pathway|negative regulation of MDA5 signaling pathway|negative regulation of melanoma differentiation-associated gene 5 signaling pathway http://purl.obolibrary.org/obo/GO_0039534 GO:0015586 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015586 GO:0039539 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039539 GO:0015587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015587 GO:0039537 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the host viral-induced cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response. go.json suppression by virus of host RIG-I-like receptor (RLR) signaling pathway|suppression by virus of host RIG-I/MDA5 signaling pathway|suppression by virus of host RIG-like helicase signaling pathway|suppression by virus of host RIG-like receptor signaling pathway|suppression by virus of host RLR signaling pathway|suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus|suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway http://purl.obolibrary.org/obo/GO_0039537 GO:0015588 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015588 GO:0015589 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015589 GO:0039538 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039538 GO:0015582 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015582 GO:0015583 biolink:MolecularActivity obsolete beta-glucoside [arbutin-salicin-cellobiose] permease activity OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose. go.json beta-glucoside [arbutin-salicin-cellobiose] permease activity True http://purl.obolibrary.org/obo/GO_0015583 GO:0015584 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015584 GO:0015585 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015585 GO:0039531 biolink:BiologicalProcess regulation of cytoplasmic pattern recognition receptor signaling pathway Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway. go.json regulation of MAV signaling|regulation of cytosolic pattern recognition receptor signaling pathway|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway http://purl.obolibrary.org/obo/GO_0039531 GO:0039532 biolink:BiologicalProcess negative regulation of cytoplasmic pattern recognition receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway. go.json negative regulation of MAVS signaling|negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus|negative regulation of cytosolic pattern recognition receptor signaling pathway|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway http://purl.obolibrary.org/obo/GO_0039532 GO:0015580 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015580 GO:0039530 biolink:BiologicalProcess MDA-5 signaling pathway The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. go.json IFIH1 signaling pathway|MDA-5 signalling pathway|MDA5 signaling pathway|melanoma differentiation-associated gene 5 signaling pathway http://purl.obolibrary.org/obo/GO_0039530 GO:0015581 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015581 GO:0039524 biolink:BiologicalProcess suppression by virus of host mRNA processing Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. VZ:903 go.json inhibition by virus of host mRNA processing|inhibition of host mRNA processing by virus|inhibition of host pre-mRNA processing by virus|negative regulation by virus of host mRNA processing http://purl.obolibrary.org/obo/GO_0039524 GO:0015557 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015557 GO:0015558 biolink:MolecularActivity secondary active p-aminobenzoyl-glutamate transmembrane transporter activity Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid. RHEA:35043 go.json p-aminobenzoyl-glutamate transmembrane transporter activity|p-aminobenzoyl-glutamate transporter activity|p-aminobenzoyl-glutamate uptake permease activity|p-aminobenzoyl-glutamate uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015558 GO:0039525 biolink:BiologicalProcess modulation by virus of host chromatin organization Any process in which a virus effects a change in the organization of chromatin in the host. go.json modulation by virus of host chromatin organisation|modulation of host chromatin by virus|modulation of host chromatin structure by virus|regulation by virus of host chromatin organization http://purl.obolibrary.org/obo/GO_0039525 GO:0039522 biolink:BiologicalProcess suppression by virus of host mRNA export from nucleus Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism. VZ:902 go.json inhibition by virus of host mRNA nuclear export|inhibition of host mRNA nuclear export by virus|negative regulation by virus of host mRNA nuclear export|suppression of host mRNA nuclear export by virus http://purl.obolibrary.org/obo/GO_0039522 GO:0015559 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015559 GO:0039523 biolink:BiologicalProcess suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity. go.json inhibition of host RNA polymerase II activity by virus|inhibition of host RNA polymerase II by virus|negative regulation by virus of host RNA polymerase II activity|suppression by virus of host RNA polymerase II activity http://purl.obolibrary.org/obo/GO_0039523 GO:0015553 biolink:MolecularActivity xanthosine transmembrane transporter activity Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015553 GO:0039528 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039528 GO:0039529 biolink:BiologicalProcess RIG-I signaling pathway The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. go.json DDX58 signaling pathway|RIG-I signalling pathway|RIG-I-like receptor (RLR) signaling pathway|RIG-like helicase signaling pathway|RIG-like receptor signaling pathway|RLH signaling pathway|RLR signaling pathway|retinoic acid inducible gene I signaling pathway http://purl.obolibrary.org/obo/GO_0039529 GO:0015554 biolink:MolecularActivity tartrate transmembrane transporter activity Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria. go.json http://purl.obolibrary.org/obo/GO_0015554 GO:0039526 biolink:BiologicalProcess perturbation by virus of host apoptosis A process in which a viral gene product affects host apoptosis, leading to a change in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. VZ:1581 go.json modulation by virus of host apoptosis|modulation by virus of host apoptotic process|modulation of host cell apoptosis by virus|perturbation by virus of host apoptotic process|regulation by virus of host apoptosis http://purl.obolibrary.org/obo/GO_0039526 GO:0015555 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015555 GO:0039527 biolink:BiologicalProcess disruption by virus of host TRAF-mediated signal transduction A process in which a virus interferes with, inhibits or stops TRAF-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json inhibition of host TRAF-mediated signal transduction by virus|inhibition of host TRAFs by virus|negative regulation by virus of host TRAF-mediated signal transduction|suppression by virus of host TRAF activity|suppression by virus of host TRAF-mediated signal transduction|suppression by virus of host tumor necrosis factor receptor-associated factor signaling http://purl.obolibrary.org/obo/GO_0039527 GO:0015556 biolink:MolecularActivity C4-dicarboxylate transmembrane transporter activity Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015556 GO:0015550 biolink:MolecularActivity galacturonate transmembrane transporter activity Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. go.json http://purl.obolibrary.org/obo/GO_0015550 GO:0015551 biolink:MolecularActivity 3-hydroxyphenyl propanoate transmembrane transporter activity Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other. go.json 3-hydroxyphenyl propionate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015551 GO:0015552 biolink:MolecularActivity propionate transmembrane transporter activity Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH. go.json http://purl.obolibrary.org/obo/GO_0015552 GO:0039520 biolink:BiologicalProcess induction by virus of host autophagy Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host. VZ:846 go.json activation of host autophagy by virus|autophagy of host cells involved in interaction with symbiont|positive regulation by virus of host autophagy http://purl.obolibrary.org/obo/GO_0039520 GO:0039521 biolink:BiologicalProcess suppression by virus of host autophagy Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host. go.json inhibition by virus of host autophagy|inhibition of host autophagy by virus|negative regulation by virus of host autophagy http://purl.obolibrary.org/obo/GO_0039521 GO:0039519 biolink:BiologicalProcess modulation by virus of host autophagy Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host. go.json regulation by virus of host autophagy http://purl.obolibrary.org/obo/GO_0039519 GO:0039513 biolink:BiologicalProcess suppression by virus of host catalytic activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. go.json down-regulation by virus of host enzyme activity|downregulation by virus of host catalytic activity|inhibition by virus of host catalytic activity|negative regulation by virus of host catalytic activity http://purl.obolibrary.org/obo/GO_0039513 GO:0015568 biolink:MolecularActivity L-idonate transmembrane transporter activity Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. go.json L-idonate/D-gluconate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015568 GO:0015569 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015569 GO:0039514 biolink:BiologicalProcess disruption by virus of host JAK-STAT cascade A process in which a virus interferes with, inhibits or stops the JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down-regulation by virus of host JAK-STAT cascade|downregulation by virus of host JAK-STAT cascade|inhibition by virus of host JAK-STAT cascade|negative regulation by virus of host JAK-STAT cascade|suppression by virus of host JAK-STAT cascade http://purl.obolibrary.org/obo/GO_0039514 GO:0039511 biolink:BiologicalProcess obsolete suppression by virus of host interferon receptor activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor. VZ:843 go.json down-regulation by virus of host interferon receptor activity|downregulation by virus of host interferon receptor activity|inhibition by virus of host interferon receptor activity|inhibition of host interferon receptors by virus|negative regulation by virus of host interferon receptor activity True http://purl.obolibrary.org/obo/GO_0039511 GO:0039512 biolink:BiologicalProcess obsolete suppression by virus of host protein tyrosine kinase activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity. go.json down-regulation by virus of host protein tyrosine kinase activity|downregulation by virus of host protein tyrosine kinase activity|inhibition by virus of host protein tyrosine kinase activity|negative regulation by virus of host protein tyrosine kinase activity True http://purl.obolibrary.org/obo/GO_0039512 GO:0015564 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015564 GO:0039517 biolink:BiologicalProcess obsolete modulation by virus of host protein serine/threonine phosphatase activity OBSOLETE. The process in which a virus effects a change in host protein serine/threonine phosphatase activity. go.json modulation by virus of protein serine/threonine phosphatase activity in host|regulation by virus of host protein serine/threonine phosphatase activity True http://purl.obolibrary.org/obo/GO_0039517 GO:0039518 biolink:BiologicalProcess obsolete suppression by virus of host cytokine activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity. go.json down-regulation by virus of host cytokine activity|downregulation by virus of host cytokine activity|inhibition by virus of host cytokine activity|negative regulation by virus of host cytokine activity True http://purl.obolibrary.org/obo/GO_0039518 GO:0015565 biolink:MolecularActivity threonine efflux transmembrane transporter activity Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane. RHEA:35019 go.json threonine efflux permease activity|threonine export protein|threonine export transporter activity http://purl.obolibrary.org/obo/GO_0015565 GO:0015566 biolink:MolecularActivity obsolete acriflavine transmembrane transporter activity OBSOLETE. Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. go.json acriflavin resistant pump activity|acriflavin transporter activity|acriflavine transporter activity True http://purl.obolibrary.org/obo/GO_0015566 GO:0039515 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039515 GO:0015567 biolink:MolecularActivity alkane transmembrane transporter activity Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds. go.json http://purl.obolibrary.org/obo/GO_0015567 GO:0039516 biolink:BiologicalProcess modulation by virus of host catalytic activity The process in which a virus effects a change in host enzyme activity. go.json modulation of catalytic activity of host by virus|regulation by virus of host catalytic activity|regulation of host catalytic activity by virus http://purl.obolibrary.org/obo/GO_0039516 GO:0015560 biolink:MolecularActivity obsolete L-idonate/D-gluconate:hydrogen symporter activity OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in). go.json L-idonate/D-gluconate:hydrogen symporter activity|L-idonate/D-gluconate:proton symporter True http://purl.obolibrary.org/obo/GO_0015560 GO:0015561 biolink:MolecularActivity rhamnose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in). TC:2.A.7.6 go.json rhamnose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015561 GO:0015562 biolink:MolecularActivity efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. go.json efflux permease activity|efflux transporter activity|monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity http://purl.obolibrary.org/obo/GO_0015562 GO:0015563 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015563 GO:0039510 biolink:BiologicalProcess obsolete suppression by virus of host ATP-dependent RNA helicase activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity. go.json down-regulation by virus of host ATP-dependent RNA helicase activity|downregulation by virus of host ATP-dependent RNA helicase activity|inhibition by virus of host ATP-dependent RNA helicase activity|negative regulation by virus of host ATP-dependent RNA helicase activity True http://purl.obolibrary.org/obo/GO_0039510 GO:0098046 biolink:CellularComponent type V protein secretion system complex A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). go.json T5SS complex|autotransporter system complex http://purl.obolibrary.org/obo/GO_0098046 GO:0098045 biolink:BiologicalProcess virus baseplate assembly The aggregation, arrangement and bonding together of a set of components to form a virus baseplate. go.json http://purl.obolibrary.org/obo/GO_0098045 GO:1990400 biolink:MolecularActivity mitochondrial ribosomal large subunit rRNA binding Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA). go.json 21S rRNA binding|mitochondrial LSU rRNA binding http://purl.obolibrary.org/obo/GO_1990400 GO:1990401 biolink:BiologicalProcess embryonic lung development The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_1990401 GO:1990406 biolink:CellularComponent CGRP receptor complex A transmembrane, G protein-coupled signaling receptor complex recognized by calcitonin gene-related peptides (CGRP). go.json CGRP-R complex|Calcitonin-gene-related peptide receptor complex|calcitonin gene-related polypeptide receptor complex http://purl.obolibrary.org/obo/GO_1990406 GO:1990407 biolink:MolecularActivity calcitonin gene-related peptide binding Binding to calcitonin gene-related peptide (CGRP). go.json CGRP polypeptide binding|calcitonin-gene-related peptide binding|calcitonin-gene-related polypeptide binding http://purl.obolibrary.org/obo/GO_1990407 GO:1990408 biolink:BiologicalProcess calcitonin gene-related peptide receptor signaling pathway The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers. go.json CGRP receptor signaling pathway|calcitonin-gene-related peptide receptor signaling pathway|calcitonin-gene-related polypeptide receptor signaling pathway http://purl.obolibrary.org/obo/GO_1990408 GO:1990409 biolink:MolecularActivity adrenomedullin binding Binding to adrenomedullin (AM). go.json AM binding http://purl.obolibrary.org/obo/GO_1990409 GO:1990402 biolink:BiologicalProcess embryonic liver development The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_1990402 GO:1990403 biolink:BiologicalProcess embryonic brain development The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_1990403 GO:1990404 biolink:MolecularActivity NAD+-protein ADP-ribosyltransferase activity Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. Wikipedia:ADP-ribosylation go.json protein ADP-ribosylase activity|protein ADP-ribosyltransferase activity|ribosylase activity http://purl.obolibrary.org/obo/GO_1990404 GO:1990405 biolink:MolecularActivity protein antigen binding Binding to a protein antigen. go.json http://purl.obolibrary.org/obo/GO_1990405 GO:0098026 biolink:CellularComponent virus tail, tube The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm. go.json bacteriophage tail tube http://purl.obolibrary.org/obo/GO_0098026 GO:1990410 biolink:BiologicalProcess adrenomedullin receptor signaling pathway The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell. go.json AM receptor signaling pathway http://purl.obolibrary.org/obo/GO_1990410 GO:0098027 biolink:CellularComponent virus tail, sheath The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm. go.json bacteriophage tail sheath http://purl.obolibrary.org/obo/GO_0098027 GO:1990411 biolink:MolecularActivity hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium. MetaCyc:RXN-14428|RHEA:42688 go.json http://purl.obolibrary.org/obo/GO_1990411 GO:0098024 biolink:CellularComponent virus tail, fiber The fibrous region of the virus tail used to scan, recognize and attach to the host cell. go.json bacteriophage tail fiber http://purl.obolibrary.org/obo/GO_0098024 GO:1990412 biolink:MolecularActivity hercynylselenocysteine lyase activity (selenoneine-forming) Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium. RHEA:42696 go.json http://purl.obolibrary.org/obo/GO_1990412 GO:0098025 biolink:CellularComponent virus tail, baseplate Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached. go.json bacteriophage baseplate|tail structure|tail tip http://purl.obolibrary.org/obo/GO_0098025 GO:0098022 biolink:CellularComponent viral capsid, fiber A type of capsid decoration composed of fiber structures. go.json head/capsid fiber http://purl.obolibrary.org/obo/GO_0098022 GO:0098023 biolink:CellularComponent virus tail, tip The basal end of the virus tail, which is used by the virus to attach to the host cell. go.json bacteriophage tail tip http://purl.obolibrary.org/obo/GO_0098023 GO:0098020 biolink:CellularComponent obsolete virus tail, minor subunit OBSOLETE. The part of the viral tail that comprises the least common subunit type. go.json bacteriophage minor protein subunit|minor tail protein True http://purl.obolibrary.org/obo/GO_0098020 GO:0098021 biolink:CellularComponent viral capsid, decoration Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential. go.json decoration protein http://purl.obolibrary.org/obo/GO_0098021 GO:1990417 biolink:BiologicalProcess snoRNA release from pre-rRNA The release of snoRNA from pre-rRNA. go.json http://purl.obolibrary.org/obo/GO_1990417 GO:1990418 biolink:BiologicalProcess response to insulin-like growth factor stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. go.json http://purl.obolibrary.org/obo/GO_1990418 GO:1990419 biolink:BiologicalProcess obsolete response to elemental metal OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an elemental metal stimulus. go.json response to elemental metal True http://purl.obolibrary.org/obo/GO_1990419 GO:1990413 biolink:CellularComponent eyespot apparatus A small pigmented organelle used in single-celled organisms to detect light. go.json eyespot|stigma http://purl.obolibrary.org/obo/GO_1990413 GO:1990414 biolink:BiologicalProcess replication-born double-strand break repair via sister chromatid exchange The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks. go.json replication-born DSB repair by SCE http://purl.obolibrary.org/obo/GO_1990414 GO:1990415 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990415 GO:0098028 biolink:CellularComponent virus tail, shaft The tube of the non-contractile tails of some viruses. go.json bacteriophage tail shaft http://purl.obolibrary.org/obo/GO_0098028 GO:1990416 biolink:BiologicalProcess cellular response to brain-derived neurotrophic factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus. go.json cellular response to BDNF stimulus http://purl.obolibrary.org/obo/GO_1990416 GO:0098029 biolink:CellularComponent icosahedral viral capsid, spike A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell. go.json http://purl.obolibrary.org/obo/GO_0098029 GO:0098037 biolink:BiologicalProcess viral DNA genome packaging, 5' extended cos packaging The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends. go.json http://purl.obolibrary.org/obo/GO_0098037 GO:1990420 biolink:BiologicalProcess establishment of septation initiation network asymmetry The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies. go.json establishment of SIN asymmetry http://purl.obolibrary.org/obo/GO_1990420 GO:0098038 biolink:BiologicalProcess non-replicative DNA transposition Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition. go.json cut-and-paste transposition|non-replicative transposition, DNA-mediated http://purl.obolibrary.org/obo/GO_0098038 GO:1990421 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990421 GO:1990422 biolink:MolecularActivity glyoxalase (glycolic acid-forming) activity Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. go.json http://purl.obolibrary.org/obo/GO_1990422 GO:0098035 biolink:BiologicalProcess viral DNA genome packaging via site-specific sequence recognition The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase. go.json http://purl.obolibrary.org/obo/GO_0098035 GO:0098036 biolink:BiologicalProcess viral DNA genome packaging, 3' extended cos packaging The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends. go.json http://purl.obolibrary.org/obo/GO_0098036 GO:1990423 biolink:CellularComponent RZZ complex A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints. go.json Rod-Zwilch-Zw10 complex http://purl.obolibrary.org/obo/GO_1990423 GO:0098033 biolink:CellularComponent icosahedral viral capsid, neck fiber A fiber attached to the neck at the base of some icosahedral viral capsids. go.json http://purl.obolibrary.org/obo/GO_0098033 GO:0098031 biolink:CellularComponent icosahedral viral capsid, collar A small disk located at the base of some icosahedral virus capsids. go.json http://purl.obolibrary.org/obo/GO_0098031 GO:0098032 biolink:CellularComponent icosahedral viral capsid, collar fiber A fiber attached to the collar structure of some icosahedral viral capsids. go.json http://purl.obolibrary.org/obo/GO_0098032 GO:0098030 biolink:CellularComponent icosahedral viral capsid, neck A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae). go.json http://purl.obolibrary.org/obo/GO_0098030 GO:1990428 biolink:BiologicalProcess miRNA transport The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. go.json microRNA transport http://purl.obolibrary.org/obo/GO_1990428 GO:1990429 biolink:CellularComponent peroxisomal importomer complex A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. go.json Pex14 complex|Pex17p-Pex14p docking complex|peroxisomal import pore|peroxisomal protein import machinery http://purl.obolibrary.org/obo/GO_1990429 GO:1990424 biolink:MolecularActivity protein arginine kinase activity Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate. go.json protein-arginine kinase activity http://purl.obolibrary.org/obo/GO_1990424 GO:1990425 biolink:CellularComponent ryanodine receptor complex A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom. go.json RyR http://purl.obolibrary.org/obo/GO_1990425 GO:0098039 biolink:BiologicalProcess replicative DNA transposition Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition. go.json copy-and-paste transposition|replicative transposition, DNA-mediated|transpositional DNA genome replication http://purl.obolibrary.org/obo/GO_0098039 GO:1990426 biolink:BiologicalProcess mitotic recombination-dependent replication fork processing Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart. go.json homologous recombination dependent replication fork recovery|homologous recombination-dependent replication fork processing|mitotic recombination involved in collapsed replication fork processing|mitotic recombination involved in recovery from replication fork arrest|mitotic recombination involved in recovery from replication fork stalling|mitotic recombination involved in replication fork processing|mitotic recombination involved in replication fork restart|mitotic recombination involved in replication restart http://purl.obolibrary.org/obo/GO_1990426 GO:1990427 biolink:CellularComponent stereocilia tip-link density An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane. go.json http://purl.obolibrary.org/obo/GO_1990427 GO:0098061 biolink:CellularComponent viral capsid, internal space The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins. go.json internal head protein http://purl.obolibrary.org/obo/GO_0098061 GO:0050026 biolink:MolecularActivity L-glycol dehydrogenase activity Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+. EC:1.1.1.185|MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN go.json L-(+)-glycol:NAD(P) oxidoreductase activity|L-glycol:NAD(P) dehydrogenase activity|L-glycol:NAD(P)+ oxidoreductase activity|glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050026 GO:0050027 biolink:MolecularActivity obsolete L-idonate 2-dehydrogenase activity OBSOLETE. Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH. EC:1.1.1.128|MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN|RHEA:21176 go.json 5-keto-D-gluconate 2-reductase activity|5-ketogluconate 2-reductase activity|5-ketoglucono-idono-reductase activity|5KGR|L-idonate 2-dehydrogenase activity|L-idonate dehydrogenase activity|L-idonate:NADP+ 2-oxidoreductase activity|reductase, 5-ketogluconate 5- (L-idonate-forming) True http://purl.obolibrary.org/obo/GO_0050027 GO:0050024 biolink:MolecularActivity L-galactonolactone oxidase activity Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+. EC:1.3.3.12|KEGG_REACTION:R00643|MetaCyc:1.3.3.12-RXN|RHEA:20617 go.json L-galactono-1,4-lactone oxidase activity|L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity|L-xylono-1,4-lactone oxidase activity http://purl.obolibrary.org/obo/GO_0050024 GO:0050025 biolink:MolecularActivity L-glutamate oxidase activity Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2. EC:1.4.3.11|MetaCyc:L-GLUTAMATE-OXIDASE-RXN|RHEA:20728 go.json L-glutamate:oxygen oxidoreductase (deaminating)|L-glutamic acid oxidase activity|glutamate (acceptor) dehydrogenase activity|glutamate oxidase activity|glutamic acid oxidase activity|glutamic dehydrogenase (acceptor) http://purl.obolibrary.org/obo/GO_0050025 GO:0050028 biolink:MolecularActivity L-lysine-lactamase activity Catalysis of the reaction: L-2-aminohexano-6-lactam + H2O = L-lysine. EC:3.5.2.11|KEGG_REACTION:R00463|MetaCyc:L-LYSINE-LACTAMASE-RXN|RHEA:21388 go.json L-alpha-aminocaprolactam hydrolase activity|L-lysinamidase activity|L-lysine-1,6-lactam lactamhydrolase activity http://purl.obolibrary.org/obo/GO_0050028 GO:0050029 biolink:MolecularActivity L-lysine oxidase activity Catalysis of the reaction: L-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4. EC:1.4.3.14|KEGG_REACTION:R00447|MetaCyc:L-LYSINE-OXIDASE-RXN|MetaCyc:PWY-5311|RHEA:14437 go.json L-lysine alpha-oxidase activity|L-lysine:oxygen 2-oxidoreductase (deaminating)|L-lysyl-alpha-oxidase activity http://purl.obolibrary.org/obo/GO_0050029 GO:0050022 biolink:MolecularActivity L-arabinose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH. EC:1.1.1.46|MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN|RHEA:17925 go.json L-arabinose 1-dehydrogenase activity|L-arabinose:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050022 GO:0050023 biolink:MolecularActivity L-fuconate dehydratase activity Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O. EC:4.2.1.68|KEGG_REACTION:R03688|MetaCyc:L-FUCONATE-HYDRATASE-RXN|RHEA:22772 go.json L-fuconate hydratase activity|L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)|L-fuconate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050023 GO:0050020 biolink:MolecularActivity L-arabinonate dehydratase activity Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O. EC:4.2.1.25|KEGG_REACTION:R02522|MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN|RHEA:20968 go.json L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)|L-arabinonate hydro-lyase activity|L-arabonate dehydrase activity|L-arabonate dehydratase activity http://purl.obolibrary.org/obo/GO_0050020 GO:0050021 biolink:MolecularActivity L-arabinonolactonase activity Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate + H+. EC:3.1.1.15|KEGG_REACTION:R02526|MetaCyc:L-ARABINONOLACTONASE-RXN|RHEA:16217 go.json L-arabinono-1,4-lactone lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0050021 GO:0050037 biolink:MolecularActivity L-xylose 1-dehydrogenase activity Catalysis of the reaction: aldehydo-L-xylose + NADP+ = L-xylono-1,4-lactone + H+ + NADPH. EC:1.1.1.113|KEGG_REACTION:R03586|MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN|RHEA:15789 go.json L-xylose dehydrogenase activity|L-xylose:NADP+ 1-oxidoreductase activity|NADPH-xylose reductase activity http://purl.obolibrary.org/obo/GO_0050037 GO:0050038 biolink:MolecularActivity L-xylulose reductase (NADP+) activity Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH. EC:1.1.1.10|KEGG_REACTION:R01904|MetaCyc:L-XYLULOSE-REDUCTASE-RXN|RHEA:17025|Reactome:R-HSA-5661240|Reactome:R-HSA-5662851 go.json L-xylulose reductase activity http://purl.obolibrary.org/obo/GO_0050038 GO:0050035 biolink:MolecularActivity L-sorbose oxidase activity Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2. EC:1.1.3.11|KEGG_REACTION:R01695|MetaCyc:L-SORBOSE-OXIDASE-RXN|RHEA:17853 go.json L-sorbose:oxygen 5-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050035 GO:0050036 biolink:MolecularActivity L-threonate 3-dehydrogenase activity Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH. EC:1.1.1.129|KEGG_REACTION:R03733|MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN|RHEA:23376 go.json L-threonate:NAD+ 3-oxidoreductase activity|L-threonic acid dehydrogenase activity|threonate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050036 GO:0050039 biolink:MolecularActivity lactaldehyde reductase (NADPH) activity Catalysis of the reaction: NADP+ + propane-1,2-diol = (S)-lactaldehyde + H+ + NADPH. EC:1.1.1.55|KEGG_REACTION:R02259|MetaCyc:RXN-15744|RHEA:15885 go.json 1,2-propanediol:NADP+ oxidoreductase activity|NADP-1,2-propanediol dehydrogenase activity|lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|propane-1,2-diol:NADP+ oxidoreductase activity|propanediol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050039 GO:0015708 biolink:BiologicalProcess silicic acid import across plasma membrane The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. go.json silicate transport|silicic acid import|silicic acid transport|silicon uptake http://purl.obolibrary.org/obo/GO_0015708 GO:0015709 biolink:BiologicalProcess thiosulfate transport The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json thiosulphate transport http://purl.obolibrary.org/obo/GO_0015709 GO:0015704 biolink:BiologicalProcess cyanate transport The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015704 GO:0015705 biolink:BiologicalProcess iodide transport The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015705 GO:0015706 biolink:BiologicalProcess nitrate transmembrane transport The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json low affinity nitrate transport|low-affinity nitrate transport|nitrate transport http://purl.obolibrary.org/obo/GO_0015706 GO:0015707 biolink:BiologicalProcess nitrite transport The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015707 GO:0015700 biolink:BiologicalProcess arsenite transport The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015700 GO:0015701 biolink:BiologicalProcess bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015701 GO:0015702 biolink:BiologicalProcess chlorate transport The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015702 GO:0015703 biolink:BiologicalProcess chromate transport The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015703 GO:0050030 biolink:MolecularActivity L-pipecolate dehydrogenase activity Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. EC:1.5.99.3|MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN|RHEA:19777 go.json L-pipecolate:(acceptor) 1,6-oxidoreductase activity|L-pipecolate:acceptor 1,6-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050030 GO:0050033 biolink:MolecularActivity L-rhamnono-1,4-lactonase activity Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+. EC:3.1.1.65|KEGG_REACTION:R03772|MetaCyc:L-RHAMNONO-14-LACTONASE-RXN|RHEA:10288 go.json L-rhamno-gamma-lactonase activity|L-rhamnono-1,4-lactone lactonohydrolase activity|L-rhamnono-gamma-lactonase activity http://purl.obolibrary.org/obo/GO_0050033 GO:0050034 biolink:MolecularActivity L-rhamnose 1-dehydrogenase activity Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamnono-1,4-lactone + H+ + NADH. EC:1.1.1.173|KEGG_REACTION:R03942|MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN|RHEA:12649 go.json L-rhamnofuranose:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050034 GO:0050031 biolink:MolecularActivity L-pipecolate oxidase activity Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. EC:1.5.3.7|KEGG_REACTION:R02204|MetaCyc:L-PIPECOLATE-OXIDASE-RXN|RHEA:11992|Reactome:R-HSA-6783880 go.json L-pipecolate:oxygen 1,6-oxidoreductase activity|L-pipecolic acid oxidase activity http://purl.obolibrary.org/obo/GO_0050031 GO:0050032 biolink:MolecularActivity L-rhamnonate dehydratase activity Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. EC:4.2.1.90|KEGG_REACTION:R03774|MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN|RHEA:23080 go.json L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)|L-rhamnonate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050032 GO:0050048 biolink:MolecularActivity L-leucine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. EC:2.6.1.6|MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN|RHEA:18321 go.json L-leucine aminotransferase activity|leucine 2-oxoglutarate transaminase activity|leucine aminotransferase activity|leucine transaminase activity|leucine-alpha-ketoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0050048 GO:0050049 biolink:MolecularActivity leucine dehydrogenase activity Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH. EC:1.4.1.9|MetaCyc:LEUCINE-DEHYDROGENASE-RXN|RHEA:12220 go.json L-leucine dehydrogenase activity|L-leucine:NAD+ oxidoreductase (deaminating)|L-leucine:NAD+ oxidoreductase, deaminating|LeuDH activity http://purl.obolibrary.org/obo/GO_0050049 GO:0050046 biolink:MolecularActivity delta7-sterol 5(6)-desaturase activity Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O. EC:1.14.19.20|MetaCyc:1.14.21.6-RXN|RHEA:46556 go.json 5-DES|delta7-sterol 5-desaturase activity|delta7-sterol delta5-dehydrogenase activity|delta7-sterol-C5(6)-desaturase activity|lathosterol 5-desaturase activity|lathosterol oxidase activity http://purl.obolibrary.org/obo/GO_0050046 GO:0050047 biolink:MolecularActivity leucine 2,3-aminomutase activity Catalysis of the reaction: L-leucine = (3R)-beta-leucine. EC:5.4.3.7|KEGG_REACTION:R01091|MetaCyc:LEUCINE-23-AMINOMUTASE-RXN|RHEA:10284 go.json (2S)-alpha-leucine 2,3-aminomutase activity http://purl.obolibrary.org/obo/GO_0050047 GO:0050040 biolink:MolecularActivity lactate 2-monooxygenase activity Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O. EC:1.13.12.4|KEGG_REACTION:R00319|MetaCyc:LACTATE-2-MONOOXYGENASE-RXN|RHEA:16513 go.json (S)-lactate:oxygen 2-oxidoreductase (decarboxylating)|L-lactate monooxygenase activity|L-lactate-2-monooxygenase activity|lactate monooxygenase activity|lactate oxidase activity|lactate oxidative decarboxylase activity|lactate oxygenase activity|lactic oxidase activity|lactic oxygenase activity http://purl.obolibrary.org/obo/GO_0050040 GO:0050041 biolink:MolecularActivity lactate aldolase activity Catalysis of the reaction: (S)-lactate = acetaldehyde + formate. EC:4.1.2.36|KEGG_REACTION:R00753|MetaCyc:LACTATE-ALDOLASE-RXN|RHEA:17909 go.json (S)-lactate acetaldehyde-lyase (formate-forming)|(S)-lactate acetaldehyde-lyase activity|lactate synthase activity http://purl.obolibrary.org/obo/GO_0050041 GO:0050044 biolink:MolecularActivity galactose-6-phosphate isomerase activity Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate. EC:5.3.1.26|KEGG_REACTION:R03240|MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN|RHEA:13033 go.json D-galactose-6-phosphate aldose-ketose-isomerase activity|D-galactose-6-phosphate ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0050044 GO:0050045 biolink:MolecularActivity laminaribiose phosphorylase activity Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate. EC:2.4.1.31|MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN|RHEA:16617 go.json 3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050045 GO:0050042 biolink:MolecularActivity lactate-malate transhydrogenase activity Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate. EC:1.1.99.7|KEGG_REACTION:R01447|MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN|RHEA:10984 go.json (S)-lactate:oxaloacetate oxidoreductase activity|malate-lactate transhydrogenase activity http://purl.obolibrary.org/obo/GO_0050042 GO:0050043 biolink:MolecularActivity lactate racemase activity Catalysis of the reaction: (S)-lactate = (R)-lactate. EC:5.1.2.1|KEGG_REACTION:R01450|MetaCyc:LACTATE-RACEMASE-RXN|RHEA:10960 go.json hydroxyacid racemase activity|lactic acid racemase activity|lacticoracemase activity http://purl.obolibrary.org/obo/GO_0050043 GO:0050059 biolink:MolecularActivity lombricine kinase activity Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine. EC:2.7.3.5|MetaCyc:LOMBRICINE-KINASE-RXN|RHEA:23292 go.json ATP:lombricine N-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050059 GO:0050057 biolink:MolecularActivity linamarin synthase activity Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin. EC:2.4.1.63|MetaCyc:LINAMARIN-SYNTHASE-RXN|RHEA:20009 go.json UDP glucose ketone cyanohydrin glucosyltransferase activity|UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity|UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity|UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity|uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity|uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity|uridine diphosphoglucose-ketone glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050057 GO:0050058 biolink:MolecularActivity linoleate isomerase activity Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate. EC:5.2.1.5|KEGG_REACTION:R03627|MetaCyc:LINOLEATE-ISOMERASE-RXN|RHEA:17381 go.json linoleate delta12-cis-delta11-trans-isomerase activity|linoleic acid isomerase activity http://purl.obolibrary.org/obo/GO_0050058 GO:0050051 biolink:MolecularActivity leukotriene-B4 20-monooxygenase activity Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.94|MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN|RHEA:22176|Reactome:R-HSA-211873 go.json LTB(4) 20-hydroxylase activity|LTB(4) omega-hydroxylase activity|LTB4 20-hydroxylase activity|LTB4 omega-hydroxylase activity|leukotriene-B4 20-hydroxylase activity|leukotriene-B4 omega-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050051 GO:0050052 biolink:MolecularActivity leukotriene-E4 20-monooxygenase activity Catalysis of the reaction: H+ + leukotriene E(4) + NADPH + O2 = 20-hydroxy-leukotriene E(4) + H2O + NADP+. EC:1.14.13.34|KEGG_REACTION:R04256|MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN|RHEA:24120 go.json (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)|leukotriene-E(4) omega-hydroxylase activity|leukotriene-E4 omega-hydroxylase activity|leukotriene-E4 w-hydroxylase activity http://purl.obolibrary.org/obo/GO_0050052 GO:0050050 biolink:MolecularActivity leucine N-acetyltransferase activity Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+. EC:2.3.1.66|KEGG_REACTION:R01089|MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN|RHEA:20089 go.json acetyl-CoA:L-leucine N-acetyltransferase activity|leucine acetyltransferase activity http://purl.obolibrary.org/obo/GO_0050050 GO:0050055 biolink:MolecularActivity limonin-D-ring-lactonase activity Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate. EC:3.1.1.36|MetaCyc:LIMONIN-D-RING-LACTONASE-RXN|RHEA:10896 go.json limonin lactone hydrolase activity|limonin-D-ring-lactone hydrolase activity|limonoate-D-ring-lactone lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0050055 GO:0050056 biolink:MolecularActivity linalool 8-monooxygenase activity Catalysis of the reaction: AH(2) + linalool + O2 = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H2O. EC:1.14.14.84|KEGG_REACTION:R04366|MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN|RHEA:32635 go.json 3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating) http://purl.obolibrary.org/obo/GO_0050056 GO:0050053 biolink:MolecularActivity levansucrase activity Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1). EC:2.4.1.10|MetaCyc:LEVANSUCRASE-RXN|RHEA:13653 go.json beta-2,6-fructan:D-glucose 1-fructosyltransferase activity|beta-2,6-fructosyltransferase activity|sucrose 6-fructosyl transferase activity|sucrose 6-fructosyltransferase activity|sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity http://purl.obolibrary.org/obo/GO_0050053 GO:0050054 biolink:MolecularActivity lignostilbene alpha beta-dioxygenase activity Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin. EC:1.13.11.43|KEGG_REACTION:R00043|MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN|RHEA:21340 go.json 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)|lignostilbene ab-dioxygenase activity|lignostilbene alphabeta-dioxygenase activity http://purl.obolibrary.org/obo/GO_0050054 GO:0098004 biolink:BiologicalProcess virus tail fiber assembly The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber. go.json http://purl.obolibrary.org/obo/GO_0098004 GO:0098005 biolink:BiologicalProcess viral head-tail joining Process by which virus heads and tails are attached to each other. go.json phage head tail joining|virus head-tail joining http://purl.obolibrary.org/obo/GO_0098005 GO:0050068 biolink:MolecularActivity lysine carbamoyltransferase activity Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate. EC:2.1.3.8|KEGG_REACTION:R01396|MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN|RHEA:17121 go.json carbamoyl-phosphate:L-lysine carbamoyltransferase activity|lysine transcarbamylase activity http://purl.obolibrary.org/obo/GO_0050068 GO:0098002 biolink:BiologicalProcess receptor-mediated bacteriophage irreversible attachment to host cell The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell. go.json irreversible bacteriophage attachment, binding of host cell surface receptor|phage irreversible adsorption http://purl.obolibrary.org/obo/GO_0098002 GO:0098003 biolink:BiologicalProcess viral tail assembly The aggregation, arrangement and bonding together of a set of components to form a virus tail. go.json bacteriophage tail assembly|virus tail assembly http://purl.obolibrary.org/obo/GO_0098003 GO:0050069 biolink:MolecularActivity lysine dehydrogenase activity Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH. EC:1.4.1.15|MetaCyc:LYSINE-DEHYDROGENASE-RXN|RHEA:18505 go.json L-lysine:NAD+ oxidoreductase (deaminating, cyclizing) http://purl.obolibrary.org/obo/GO_0050069 GO:0098001 biolink:BiologicalProcess receptor-mediated bacteriophage reversible attachment to host cell Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection. go.json phage reversible adsorption|reversible bacteriophage attachment, binding of host cell surface receptor http://purl.obolibrary.org/obo/GO_0098001 GO:0050062 biolink:MolecularActivity long-chain-fatty-acyl-CoA reductase activity Catalysis of the reaction: a long-chain fatty aldehyde + CoA + NADP+ = a long-chain fatty acyl-CoA + NADPH. EC:1.2.1.50|MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN|RHEA:15437 go.json acyl coenzyme A reductase activity|long-chain fatty acyl CoA reductase activity|long-chain fatty acyl-CoA reductase activity http://purl.obolibrary.org/obo/GO_0050062 GO:0050063 biolink:MolecularActivity obsolete low-density-lipoprotein particle receptor kinase activity OBSOLETE. Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine. EC:2.7.11.29|MetaCyc:2.7.11.29-RXN go.json ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity|ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity|LDL receptor kinase activity|STK7|[low-density lipoprotein receptor] kinase activity|low-density lipoprotein receptor kinase activity|low-density-lipoprotein kinase activity|low-density-lipoprotein receptor kinase (phosphorylating) activity|low-density-lipoprotein receptor kinase activity True http://purl.obolibrary.org/obo/GO_0050063 GO:0050060 biolink:MolecularActivity long-chain-alcohol dehydrogenase activity Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH. EC:1.1.1.192|MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN|RHEA:17977 go.json fatty alcohol oxidoreductase activity|long-chain alcohol dehydrogenase activity|long-chain-alcohol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050060 GO:0050061 biolink:MolecularActivity long-chain-aldehyde dehydrogenase activity Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons. EC:1.2.1.48|MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN|RHEA:10652|UM-BBD_reactionID:r1404 go.json fatty aldehyde:NAD+ oxidoreductase activity|long-chain aliphatic aldehyde dehydrogenase activity|long-chain fatty aldehyde dehydrogenase activity|long-chain-aldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050061 GO:0050066 biolink:MolecularActivity lysine 2,3-aminomutase activity Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate. EC:5.4.3.2|KEGG_REACTION:R00461|MetaCyc:LYSINE-23-AMINOMUTASE-RXN|RHEA:19177 go.json L-lysine 2,3-aminomutase activity http://purl.obolibrary.org/obo/GO_0050066 GO:0098009 biolink:CellularComponent viral terminase, large subunit The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit. go.json virus terminase, large subunit http://purl.obolibrary.org/obo/GO_0098009 GO:0050067 biolink:MolecularActivity lysine 2-monooxygenase activity Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O. EC:1.13.12.2|KEGG_REACTION:R00449|MetaCyc:LYSINE-2-MONOOXYGENASE-RXN|RHEA:14601 go.json L-lysine-2-monooxygenase activity|L-lysine:oxygen 2-oxidoreductase (decarboxylating)|lysine monooxygenase activity|lysine oxygenase activity http://purl.obolibrary.org/obo/GO_0050067 GO:0098006 biolink:BiologicalProcess viral DNA genome packaging, headful The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full. go.json phage headful packaging http://purl.obolibrary.org/obo/GO_0098006 GO:0050064 biolink:MolecularActivity luteolin 7-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP. EC:2.4.1.189|KEGG_REACTION:R03589|MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN|RHEA:10568 go.json LGT|UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity|UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity|luteolin 7-O-glucoronosyltransferase activity|uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0050064 GO:0050065 biolink:MolecularActivity lysine-pyruvate 6-transaminase activity Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine. EC:2.6.1.71|KEGG_REACTION:R00453|MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN|MetaCyc:PWY-5324|RHEA:19393 go.json L-lysine:pyruvate aminotransferase activity|Lys-AT|lysine--pyruvate 6-aminotransferase activity|lysine-pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0050065 GO:0098015 biolink:CellularComponent virus tail Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell. go.json bacteriophage tail|viral tail http://purl.obolibrary.org/obo/GO_0098015 GO:0050079 biolink:MolecularActivity acetylenecarboxylate hydratase activity, producing 3-oxopropanoate Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. EC:4.2.1.27|MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN|RHEA:17957 go.json 3-oxopropanoate hydro-lyase (propynoate-forming)|3-oxopropanoate hydro-lyase activity|acetylenecarboxylate hydratase activity|acetylenecarboxylate hydratase activity, producing malonate-semialdehyde|acetylenemonocarboxylate hydrase activity|acetylenemonocarboxylate hydratase activity|acetylmonocarboxylic acid hydrase activity|alkynoate hydratase activity|malonate-semialdehyde dehydratase activity http://purl.obolibrary.org/obo/GO_0050079 GO:0050070 biolink:MolecularActivity lysolecithin acylmutase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine. EC:5.4.1.1|KEGG_REACTION:R03334|MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN|RHEA:24356 go.json lysolecithin 2,3-acylmutase activity|lysolecithin migratase activity http://purl.obolibrary.org/obo/GO_0050070 GO:0050073 biolink:MolecularActivity macrolide 2'-kinase activity Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate. EC:2.7.1.136|KEGG_REACTION:R03780|MetaCyc:MACROLIDE-2-KINASE-RXN|RHEA:18333 go.json ATP:macrolide 2'-O-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050073 GO:0050074 biolink:MolecularActivity malate-CoA ligase activity Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA. EC:6.2.1.9|MetaCyc:MALATE--COA-LIGASE-RXN|RHEA:26193 go.json malate thiokinase activity|malate:CoA ligase (ADP-forming)|malyl coenzyme A synthetase activity|malyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0050074 GO:0050071 biolink:MolecularActivity phosphatidylglycerol lysyltransferase activity Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys). EC:2.3.2.3|MetaCyc:LYSYLTRANSFERASE-RXN|RHEA:10668 go.json lysylphosphatidylglycerol synthase activity|lysyltransferase activity http://purl.obolibrary.org/obo/GO_0050071 GO:0050072 biolink:MolecularActivity obsolete m7G(5')pppN diphosphatase activity OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. EC:3.6.1.30|MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN go.json 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|M(7)G(5')pppN pyrophosphatase activity|decapase activity|m7G(5')pppN pyrophosphatase activity True http://purl.obolibrary.org/obo/GO_0050072 GO:0050077 biolink:MolecularActivity maleylpyruvate isomerase activity Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate. EC:5.2.1.4|MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN|RHEA:17393 go.json 3-maleylpyruvate cis-trans-isomerase activity http://purl.obolibrary.org/obo/GO_0050077 GO:0098019 biolink:CellularComponent obsolete virus tail, major subunit OBSOLETE. The part of the viral tail that comprises the most common subunit type. go.json major tail protein True http://purl.obolibrary.org/obo/GO_0098019 GO:0050078 biolink:MolecularActivity malonate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA. EC:2.8.3.3|KEGG_REACTION:R00743|MetaCyc:MALONATE-COA-TRANSFERASE-RXN|RHEA:18817 go.json acetyl-CoA:malonate CoA-transferase activity|malonate coenzyme A-transferase activity http://purl.obolibrary.org/obo/GO_0050078 GO:0098017 biolink:CellularComponent viral capsid, major subunit The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits. go.json major capsomere|major head protein http://purl.obolibrary.org/obo/GO_0098017 GO:0050075 biolink:MolecularActivity maleate hydratase activity Catalysis of the reaction: (R)-malate = H2O + maleate. EC:4.2.1.31|KEGG_REACTION:R02419|MetaCyc:MALEATE-HYDRATASE-RXN|RHEA:23692 go.json (R)-malate hydro-lyase (maleate-forming)|(R)-malate hydro-lyase activity|D-malate hydro-lyase activity|malease activity http://purl.obolibrary.org/obo/GO_0050075 GO:0098018 biolink:CellularComponent viral capsid, minor subunit The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits. go.json minor capsomere|minor head protein http://purl.obolibrary.org/obo/GO_0098018 GO:0050076 biolink:MolecularActivity maleate isomerase activity Catalysis of the reaction: maleate = fumarate. EC:5.2.1.1|KEGG_REACTION:R01087|MetaCyc:MALEATE-ISOMERASE-RXN|RHEA:13169 go.json maleate cis-trans-isomerase activity http://purl.obolibrary.org/obo/GO_0050076 GO:0050080 biolink:MolecularActivity malonyl-CoA decarboxylase activity Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. EC:4.1.1.9|MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN|RHEA:18781|Reactome:R-HSA-977317 go.json malonyl coenzyme A decarboxylase activity|malonyl-CoA carboxy-lyase (acetyl-CoA-forming)|malonyl-CoA carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0050080 GO:0050081 biolink:MolecularActivity maltose-6'-phosphate glucosidase activity Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate. EC:3.2.1.122|MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN|RHEA:20421 go.json maltose-6'-phosphate 6-phosphoglucohydrolase activity|phospho-alpha-glucosidase activity http://purl.obolibrary.org/obo/GO_0050081 GO:0050084 biolink:MolecularActivity mannitol-1-phosphatase activity Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate. EC:3.1.3.22|KEGG_REACTION:R02167|MetaCyc:MANNITOL-1-PHOSPHATASE-RXN|RHEA:19537 go.json D-mannitol-1-phosphate phosphohydrolase activity|mannitol-1-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0050084 GO:0050085 biolink:MolecularActivity mannitol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH. EC:1.1.1.138|KEGG_REACTION:R00870|MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN|RHEA:16765 go.json D-mannitol:NADP+ 2-oxidoreductase activity|NADP-dependent mannitol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050085 GO:0050082 biolink:MolecularActivity maltose phosphorylase activity Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate. EC:2.4.1.8|MetaCyc:MALTOSE-PHOSPHORYLASE-RXN|RHEA:21116 go.json maltose:phosphate 1-beta-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050082 GO:0050083 biolink:MolecularActivity malyl-CoA lyase activity Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. EC:4.1.3.24|MetaCyc:MALYL-COA-LYASE-RXN|RHEA:16629 go.json (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)|(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity|malyl-coenzyme A lyase activity http://purl.obolibrary.org/obo/GO_0050083 GO:0050088 biolink:MolecularActivity mannose-6-phosphate 6-reductase activity Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH. EC:1.1.1.224|KEGG_REACTION:R01817|MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN|RHEA:14925 go.json 6-phosphomannose reductase activity|D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity|NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity|NADPH-dependent M6P reductase activity|NADPH-dependent mannose 6-phosphate reductase activity|NADPH-mannose-6-P reductase activity|mannose-6-phosphate reductase activity http://purl.obolibrary.org/obo/GO_0050088 GO:0050089 biolink:MolecularActivity mannose isomerase activity Catalysis of the reaction: D-mannose = D-fructose. EC:5.3.1.7|KEGG_REACTION:R00877|MetaCyc:MANNOSE-ISOMERASE-RXN|RHEA:22604 go.json D-mannose aldose-ketose-isomerase activity|D-mannose isomerase activity|D-mannose ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0050089 GO:0050086 biolink:MolecularActivity mannitol 2-dehydrogenase activity Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH. EC:1.1.1.67|MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN|RHEA:12084 go.json D-mannitol dehydrogenase activity|D-mannitol:NAD+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050086 GO:0050087 biolink:MolecularActivity mannitol dehydrogenase (cytochrome) activity Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+. EC:1.1.2.2|MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:17597 go.json D-mannitol:ferricytochrome-c 2-oxidoreductase activity|polyol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050087 GO:0050091 biolink:MolecularActivity melilotate 3-monooxygenase activity Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H+ + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+. EC:1.14.13.4|KEGG_REACTION:R03369|MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN|RHEA:17669 go.json 2-hydroxyphenylpropionate hydroxylase activity|2-hydroxyphenylpropionic hydroxylase activity|3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)|melilotate hydroxylase activity|melilotic hydroxylase activity http://purl.obolibrary.org/obo/GO_0050091 GO:0050092 biolink:MolecularActivity meso-tartrate dehydrogenase activity Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH. EC:1.3.1.7|KEGG_REACTION:R02544|MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN|RHEA:18553 go.json meso-tartrate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050092 GO:0050090 biolink:MolecularActivity mannuronate reductase activity Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+. EC:1.1.1.131|MetaCyc:MANNURONATE-REDUCTASE-RXN go.json D-mannonate:NAD(P)+ 6-oxidoreductase activity|D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))|mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity|mannonate dehydrogenase (NAD(P)+)|mannonate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050090 GO:0050095 biolink:MolecularActivity methionine decarboxylase activity Catalysis of the reaction: L-methionine + H+ = 3-methylthiopropanamine + CO2. EC:4.1.1.57|KEGG_REACTION:R00656|MetaCyc:METHIONINE-DECARBOXYLASE-RXN|RHEA:17757 go.json L-methionine carboxy-lyase (3-methylthiopropanamine-forming)|L-methionine carboxy-lyase activity|L-methionine decarboxylase activity http://purl.obolibrary.org/obo/GO_0050095 GO:0050096 biolink:MolecularActivity methylaspartate ammonia-lyase activity Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4. EC:4.3.1.2|KEGG_REACTION:R03696|MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN|RHEA:12829 go.json 3-methylaspartase activity|L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)|L-threo-3-methylaspartate ammonia-lyase activity|beta-methylaspartase activity http://purl.obolibrary.org/obo/GO_0050096 GO:0050093 biolink:MolecularActivity methanol dehydrogenase activity Catalysis of the reaction: methanol + NAD+ = formaldehyde + H+ + NADH. EC:1.1.1.244|KEGG_REACTION:R00605|MetaCyc:METHANOL-DEHYDROGENASE-RXN|RHEA:19401 go.json methanol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050093 GO:0050094 biolink:MolecularActivity methionine-glyoxylate transaminase activity Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine. EC:2.6.1.73|KEGG_REACTION:R00652|MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN|RHEA:22884 go.json L-methionine:glyoxylate aminotransferase activity|MGAT activity|methionine-glyoxylate aminotransferase activity http://purl.obolibrary.org/obo/GO_0050094 GO:0050099 biolink:MolecularActivity methylglutamate dehydrogenase activity Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde. EC:1.5.99.5|KEGG_REACTION:R00609|MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN|RHEA:22572 go.json N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)|N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)|N-methylglutamate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050099 GO:0050097 biolink:MolecularActivity methylaspartate mutase activity Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate. EC:5.4.99.1|KEGG_REACTION:R00262|MetaCyc:METHYLASPARTATE-MUTASE-RXN|RHEA:12857 go.json L-threo-3-methylaspartate carboxy-aminomethylmutase activity|b-methylaspartate-glutamate mutase activity|beta-methylaspartate-glutamate mutase activity|glutamate isomerase activity|glutamate mutase activity|glutamic acid isomerase activity|glutamic acid mutase activity|glutamic isomerase activity|glutamic mutase activity|methylaspartic acid mutase activity http://purl.obolibrary.org/obo/GO_0050097 GO:0050098 biolink:MolecularActivity methylguanidinase activity Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea. EC:3.5.3.16|KEGG_REACTION:R01589|MetaCyc:METHYLGUANIDINASE-RXN|RHEA:11764 go.json methylguanidine amidinohydrolase activity|methylguanidine hydrolase activity http://purl.obolibrary.org/obo/GO_0050098 GO:0001015 biolink:BiologicalProcess snoRNA transcription by RNA polymerase II The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. go.json snoRNA transcription from an RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0001015 GO:0001016 biolink:MolecularActivity RNA polymerase III transcription regulatory region sequence-specific DNA binding Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. go.json RNA polymerase III regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0001016 GO:0001017 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001017 GO:0001018 biolink:MolecularActivity mitochondrial promoter sequence-specific DNA binding Binding to a DNA region that controls the transcription of the mitochondrial DNA. go.json HSP coding strand binding|HSP non-coding strand binding|HSPas binding|HSPs binding|LSP coding strand binding|LSP non-coding strand binding|LSPas binding|LSPs binding|mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding|mitochondrial RNA polymerase core promoter sequence-specific DNA binding|mitochondrial RNA polymerase regulatory region DNA binding|mitochondrial RNA polymerase regulatory region sequence-specific DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial heavy strand promoter sense binding|mitochondrial light strand promoter anti-sense binding|mitochondrial light strand promoter sense binding|mitochondrial proximal promoter sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001018 GO:0001011 biolink:MolecularActivity obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting OBSOLETE. Binding to a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC). go.json sequence-specific DNA binding RNA polymerase recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001011 GO:0001012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001012 GO:0001013 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001013 GO:0001014 biolink:BiologicalProcess snoRNA transcription by RNA polymerase III The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter. go.json snoRNA transcription from a type 2 RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0001014 GO:0039629 biolink:CellularComponent T=219 icosahedral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins. go.json http://purl.obolibrary.org/obo/GO_0039629 GO:0001010 biolink:MolecularActivity RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions. go.json sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription factor activity, sequence-specific DNA binding transcription factor recruiting|transcription factor activity, sequence-specific DNA-binding transcription factor recruiting http://purl.obolibrary.org/obo/GO_0001010 GO:0039623 biolink:CellularComponent T=25 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres. VZ:810 go.json http://purl.obolibrary.org/obo/GO_0039623 GO:0015656 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015656 GO:0039624 biolink:CellularComponent viral outer capsid The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions. go.json outer capsid http://purl.obolibrary.org/obo/GO_0039624 GO:0015657 biolink:MolecularActivity branched-chain amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in). go.json http://purl.obolibrary.org/obo/GO_0015657 GO:0039621 biolink:CellularComponent T=13 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres. VZ:260 go.json http://purl.obolibrary.org/obo/GO_0039621 GO:0015658 biolink:MolecularActivity branched-chain amino acid transmembrane transporter activity Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. Reactome:R-HSA-9672770 go.json branched-chain aliphatic amino acid transmembrane transporter activity|branched-chain aliphatic amino acid transporter activity|leucine/valine/isoleucine permease activity|valine/tyrosine/tryptophan permease activity http://purl.obolibrary.org/obo/GO_0015658 GO:0039622 biolink:CellularComponent T=16 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres. VZ:807 go.json http://purl.obolibrary.org/obo/GO_0039622 GO:0015659 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015659 GO:0015652 biolink:MolecularActivity quaternary ammonium group:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in). go.json quaternary ammonium group:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015652 GO:0039627 biolink:CellularComponent T=147 icosahedral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins. go.json http://purl.obolibrary.org/obo/GO_0039627 GO:0015653 biolink:MolecularActivity glycine betaine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in). go.json glycine betaine:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015653 GO:0039628 biolink:CellularComponent T=169 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins. go.json T=169 icosahedral capsid http://purl.obolibrary.org/obo/GO_0039628 GO:0039625 biolink:CellularComponent viral inner capsid The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions. go.json inner capsid http://purl.obolibrary.org/obo/GO_0039625 GO:0015654 biolink:MolecularActivity tellurite transmembrane transporter activity Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals. go.json tellurite uptake transmembrane transporter activity|tellurite-resistance uptake permease activity|tellurite-resistance uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015654 GO:0039626 biolink:CellularComponent viral intermediate capsid The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions. go.json intermediate capsid http://purl.obolibrary.org/obo/GO_0039626 GO:0015655 biolink:MolecularActivity alanine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in). RHEA:29283 go.json sodium:alanine symporter activity http://purl.obolibrary.org/obo/GO_0015655 GO:0015650 biolink:MolecularActivity lactate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in). go.json lactate permease|lactate:hydrogen porter activity|lactate:hydrogen symporter activity|lactate:proton porter activity http://purl.obolibrary.org/obo/GO_0015650 GO:0015651 biolink:MolecularActivity quaternary ammonium group transmembrane transporter activity Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. go.json quaternary amine transmembrane transporter activity|quaternary ammonium compound transporter activity http://purl.obolibrary.org/obo/GO_0015651 GO:0001019 biolink:MolecularActivity plastid promoter transcription regulatory region sequence-specific DNA binding Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. go.json http://purl.obolibrary.org/obo/GO_0001019 GO:0039620 biolink:CellularComponent T=7 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres. VZ:804 go.json http://purl.obolibrary.org/obo/GO_0039620 GO:0001026 biolink:MolecularActivity obsolete TFIIIB-type transcription factor activity OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex. go.json RNA polymerase III recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001026 GO:0001027 biolink:MolecularActivity obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex. go.json RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001027 GO:0001028 biolink:MolecularActivity obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex. go.json RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001028 GO:0001029 biolink:MolecularActivity obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex. go.json RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001029 GO:0001022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001022 GO:0001023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001023 GO:0001024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001024 GO:0001025 biolink:MolecularActivity RNA polymerase III general transcription initiation factor binding Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III. go.json RNA polymerase III transcription factor binding http://purl.obolibrary.org/obo/GO_0001025 GO:0039618 biolink:CellularComponent T=pseudo3 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres. VZ:809 go.json http://purl.obolibrary.org/obo/GO_0039618 GO:0001020 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001020 GO:0001021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001021 GO:0039619 biolink:CellularComponent T=4 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres. VZ:808 go.json http://purl.obolibrary.org/obo/GO_0039619 OIO:consider biolink:OntologyClass consider go.json http://www.geneontology.org/formats/oboInOwl#consider GO:0039612 biolink:BiologicalProcess obsolete modulation by virus of host protein phosphorylation OBSOLETE. Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host. go.json True http://purl.obolibrary.org/obo/GO_0039612 GO:0015667 biolink:MolecularActivity site-specific DNA-methyltransferase (cytosine-N4-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine. EC:2.1.1.113|MetaCyc:2.1.1.113-RXN|RHEA:16857 go.json DNA[cytosine-N4]methyltransferase activity|N(4)-cytosine-specific DNA methylase activity|N4-cytosine-specific DNA methylase activity|S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity|S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity|m4C-forming MTase activity|modification methylase activity|restriction-modification system activity http://purl.obolibrary.org/obo/GO_0015667 GO:0015668 biolink:MolecularActivity type III site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites. EC:3.1.21.5|MetaCyc:3.1.21.5-RXN go.json type III restriction enzyme activity http://purl.obolibrary.org/obo/GO_0015668 GO:0039613 biolink:BiologicalProcess obsolete suppression by virus of host protein phosphorylation OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host. go.json viral inhibition of host protein phosphorylation True http://purl.obolibrary.org/obo/GO_0039613 GO:0015669 biolink:BiologicalProcess gas transport The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015669 goslim_pir GO:0039611 biolink:BiologicalProcess obsolete suppression by virus of host translation initiation factor activity OBSOLETE. Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor. go.json Inhibition of host translation factors by virus|inactivation of eIF2 activity|inhibition of activity of host translation initiation factor|suppression by virus of host EIF-4E activity True http://purl.obolibrary.org/obo/GO_0039611 GO:0039616 biolink:CellularComponent T=2 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers. VZ:838 go.json http://purl.obolibrary.org/obo/GO_0039616 GO:0015663 biolink:MolecularActivity nicotinamide mononucleotide transmembrane transporter activity Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. go.json nicotinamide mononucleotide permease activity|nicotinamide ribonucleotide transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015663 GO:0039617 biolink:CellularComponent T=3 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres. VZ:806 go.json http://purl.obolibrary.org/obo/GO_0039617 GO:0015664 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015664 GO:0015665 biolink:MolecularActivity alcohol transmembrane transporter activity Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. go.json http://purl.obolibrary.org/obo/GO_0015665 GO:0039614 biolink:BiologicalProcess obsolete induction by virus of host protein phosphorylation OBSOLETE. Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host. go.json True http://purl.obolibrary.org/obo/GO_0039614 GO:0039615 biolink:CellularComponent T=1 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres. VZ:1057 go.json http://purl.obolibrary.org/obo/GO_0039615 GO:0015666 biolink:MolecularActivity restriction endodeoxyribonuclease activity Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. go.json restriction endonuclease activity|restriction enzyme activity http://purl.obolibrary.org/obo/GO_0015666 GO:0015660 biolink:MolecularActivity formate efflux transmembrane transporter activity Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane. go.json formate efflux permease activity http://purl.obolibrary.org/obo/GO_0015660 GO:0015661 biolink:MolecularActivity L-lysine efflux transmembrane transporter activity Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane. go.json L-lysine exporter activity|L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015661 GO:0015662 biolink:MolecularActivity P-type ion transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. go.json ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|P-type ATPase activity|ion transmembrane transporter activity, phosphorylative mechanism|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity http://purl.obolibrary.org/obo/GO_0015662 GO:0039607 biolink:BiologicalProcess obsolete proteolysis by virus of host translation initiation factor OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds. go.json cleavage of host translation initiation factor by viral protease|cleavage of host translation initiation factor by virus|proteolytic cleavage by virus of host translation initiation factor|suppression by virus of host translation initiation factor activity by proteolysis True http://purl.obolibrary.org/obo/GO_0039607 GO:0039608 biolink:BiologicalProcess obsolete suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation OBSOLETE. Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein. go.json True http://purl.obolibrary.org/obo/GO_0039608 GO:0015638 biolink:MolecularActivity microcin transmembrane transporter activity Enables the transfer of a microcin from one side of a membrane to the other. go.json microcin uptake permease activity http://purl.obolibrary.org/obo/GO_0015638 GO:0015639 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015639 GO:0039601 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039601 GO:0015634 biolink:MolecularActivity obsolete lipopolysaccharide exporter activity OBSOLETE. Enables the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. go.json LPS exporter activity True http://purl.obolibrary.org/obo/GO_0015634 GO:0015635 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015635 GO:0039602 biolink:BiologicalProcess suppression by virus of host transcription initiation from RNA polymerase II promoter Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. VZ:904 go.json inhibition of host transcription initiation by virus|suppression by virus of host DNA-dependent transcription, initiation http://purl.obolibrary.org/obo/GO_0039602 GO:0015636 biolink:MolecularActivity short-chain fatty acid transmembrane transporter activity Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons. go.json short-chain fatty acid transporter activity|short-chain fatty acid uptake transporter activity http://purl.obolibrary.org/obo/GO_0015636 GO:0039600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039600 GO:0015637 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015637 GO:0015630 biolink:CellularComponent microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. go.json http://purl.obolibrary.org/obo/GO_0015630 GO:0039605 biolink:MolecularActivity obsolete TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. go.json True http://purl.obolibrary.org/obo/GO_0039605 GO:0039606 biolink:BiologicalProcess suppression by virus of host translation initiation Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein. go.json http://purl.obolibrary.org/obo/GO_0039606 GO:0015631 biolink:MolecularActivity tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules. go.json http://purl.obolibrary.org/obo/GO_0015631 GO:0039603 biolink:MolecularActivity obsolete TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. go.json True http://purl.obolibrary.org/obo/GO_0039603 GO:0015632 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015632 GO:0039604 biolink:BiologicalProcess suppression by virus of host translation Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA, for example by cleavage of the host mRNAs. VZ:1579 go.json cleavage by virus of host mRNA|host mRNA cleavage by viral endoribonuclease|host translation shutoff by virus|induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process|induction by virus of host endonucleolytic cleavage-dependent mRNA decay|viral endoribonuclease activity involved in degradation of host mRNA|viral inhibition of cellular protein synthesis|viral shutoff of host protein synthesis http://purl.obolibrary.org/obo/GO_0039604 GO:0015633 biolink:MolecularActivity ABC-type zinc transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in). EC:7.2.2.20|RHEA:29795 go.json ATP-dependent zinc transmembrane transporter activity|ATPase-coupled zinc transmembrane transporter activity|zinc porter activity|zinc transporting ATPase activity|zinc-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015633 GO:0001004 biolink:MolecularActivity obsolete RNA polymerase III transcription regulator recruiting activity OBSOLETE. Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB. go.json RNA polymerase III assembly factor activity|RNA polymerase III assembly factor activity, TFIIIB recruiting|RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity|RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III transcription factor recruiting activity|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity|SNAPc-type activity|TFIIIA activity|TFIIIC-type activity|transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting|transcription factor activity, RNA polymerase III type 1 promoter TFIIIB|transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting|transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting|transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting|type 2 RNA polymerase III promoter recognition|type 3 RNA polymerase III promoter recognition True http://purl.obolibrary.org/obo/GO_0001004 GO:0001005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001005 GO:0001006 biolink:MolecularActivity RNA polymerase III type 3 promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae. go.json RNA polymerase III type 3 promoter DNA binding http://purl.obolibrary.org/obo/GO_0001006 GO:0001007 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase III transcription factor binding OBSOLETE. Binding to an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json RNA polymerase III transcription factor binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001007 GO:0001000 biolink:MolecularActivity bacterial-type RNA polymerase core enzyme binding Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit. go.json eubacterial-type RNA polymerase core enzyme binding http://purl.obolibrary.org/obo/GO_0001000 GO:0001001 biolink:MolecularActivity mitochondrial single-subunit type RNA polymerase binding Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. go.json http://purl.obolibrary.org/obo/GO_0001001 GO:0001002 biolink:MolecularActivity RNA polymerase III type 1 promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition. go.json RNA polymerase III type 1 promoter DNA binding http://purl.obolibrary.org/obo/GO_0001002 GO:0001003 biolink:MolecularActivity RNA polymerase III type 2 promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs. go.json RNA polymerase III type 2 promoter DNA binding http://purl.obolibrary.org/obo/GO_0001003 GO:0015649 biolink:MolecularActivity 2-keto-3-deoxygluconate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in). RHEA:29943 go.json 2-keto-3-deoxygluconate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0015649 GO:0015645 biolink:MolecularActivity fatty acid ligase activity Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. go.json fatty acid CoA ligase activity|fatty acyl-coenzyme A synthetase activity|fatty-acid ligase activity http://purl.obolibrary.org/obo/GO_0015645 GO:0015646 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015646 GO:0015647 biolink:MolecularActivity peptidoglycan transmembrane transporter activity Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other. go.json murein transporter activity http://purl.obolibrary.org/obo/GO_0015647 GO:0015648 biolink:MolecularActivity lipid-linked peptidoglycan transporter activity Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. go.json lipid-linked murein transporter activity http://purl.obolibrary.org/obo/GO_0015648 GO:0015641 biolink:MolecularActivity obsolete lipoprotein toxin OBSOLETE. (Was not defined before being made obsolete). go.json lipoprotein toxin True http://purl.obolibrary.org/obo/GO_0015641 GO:0015642 biolink:MolecularActivity obsolete bacteriolytic toxin activity OBSOLETE. Acts as to cause lysis of bacterial cells. go.json bacteriolytic toxin activity True http://purl.obolibrary.org/obo/GO_0015642 GO:0015643 biolink:MolecularActivity toxic substance binding Binding to a toxic substance, a poisonous substance that causes damage to biological systems. go.json antitoxin activity|lipoprotein antitoxin http://purl.obolibrary.org/obo/GO_0015643 GO:0015644 biolink:MolecularActivity obsolete lipoprotein antitoxin OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it. go.json lipoprotein antitoxin True http://purl.obolibrary.org/obo/GO_0015644 GO:0015640 biolink:MolecularActivity peptidoglycan peptide transmembrane transporter activity Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. go.json murein peptide transporter activity|muropeptide transporter activity http://purl.obolibrary.org/obo/GO_0015640 GO:0001008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001008 GO:0001009 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001009 GO:1990398 biolink:CellularComponent Cus cation efflux complex Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth. go.json Cus cation efflux system|copper efflux complex|copper efflux system|silver efflux complex|silver efflux system http://purl.obolibrary.org/obo/GO_1990398 GO:1990399 biolink:BiologicalProcess epithelium regeneration The regrowth of lost or destroyed epithelium. go.json regeneration of epithelium http://purl.obolibrary.org/obo/GO_1990399 GO:1990394 biolink:BiologicalProcess cellular response to cell wall damage Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell. go.json http://purl.obolibrary.org/obo/GO_1990394 GO:1990395 biolink:BiologicalProcess meiotic spindle pole body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_1990395 GO:1990396 biolink:BiologicalProcess single-strand break repair via homologous recombination The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990396 GO:1990397 biolink:BiologicalProcess queuosine salvage Any process which produces queuosine from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_1990397 GO:1990390 biolink:BiologicalProcess protein K33-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein. go.json http://purl.obolibrary.org/obo/GO_1990390 GO:1990391 biolink:CellularComponent DNA repair complex A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. go.json DNA damage repair complex|WHY1 complex http://purl.obolibrary.org/obo/GO_1990391 GO:1990392 biolink:CellularComponent EFF-1 complex A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer. go.json http://purl.obolibrary.org/obo/GO_1990392 GO:1990393 biolink:CellularComponent 3M complex A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity. go.json http://purl.obolibrary.org/obo/GO_1990393 GO:0015616 biolink:MolecularActivity DNA translocase activity Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0015616 GO:0015617 biolink:MolecularActivity obsolete pilin/fimbrilin exporter activity OBSOLETE. (Was not defined before being made obsolete). go.json pilin/fimbrilin exporter activity True http://purl.obolibrary.org/obo/GO_0015617 GO:0015618 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015618 GO:0015619 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015619 GO:0015612 biolink:MolecularActivity ABC-type L-arabinose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in). EC:7.5.2.12|EC:7.5.2.13|MetaCyc:ABC-2-RXN|RHEA:30007 go.json L-arabinose porter activity|L-arabinose-importing ATPase activity http://purl.obolibrary.org/obo/GO_0015612 GO:0015613 biolink:MolecularActivity obsolete galactose/glucose (methylgalactoside) porter activity OBSOLETE. (Was not defined before being made obsolete). go.json galactose/glucose (methylgalactoside) porter activity True http://purl.obolibrary.org/obo/GO_0015613 GO:0015614 biolink:MolecularActivity ABC-type D-xylose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in). EC:7.5.2.10|RHEA:29899 go.json ATPase-coupled D-xylose transmembrane transporter activity|D-xylose porter activity|D-xylose-importing ATPase activity http://purl.obolibrary.org/obo/GO_0015614 GO:0015615 biolink:MolecularActivity D-allose-importing ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in). go.json D-allose porter activity http://purl.obolibrary.org/obo/GO_0015615 GO:0015610 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015610 GO:0015611 biolink:MolecularActivity ABC-type D-ribose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in). EC:7.5.2.8|MetaCyc:ABC-28-RXN|RHEA:29903 go.json D-ribose porter activity|D-ribose-importing ATPase activity http://purl.obolibrary.org/obo/GO_0015611 GO:0015627 biolink:CellularComponent type II protein secretion system complex A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. go.json MTB|Sec-dependent secretion system-associated complex|T2SS-associated complexes|general secretion pathway-associated complex|main terminal branch http://purl.obolibrary.org/obo/GO_0015627 GO:0015628 biolink:BiologicalProcess protein secretion by the type II secretion system The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. go.json protein secretion by the T2S|protein secretion by the T2SS|protein secretion by the general secretion pathway|protein secretion by the general secretory pathway|protein secretion by the type II protein secretion system|type II protein secretion system http://purl.obolibrary.org/obo/GO_0015628 GO:0015629 biolink:CellularComponent actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. go.json http://purl.obolibrary.org/obo/GO_0015629 GO:0015623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015623 GO:0015624 biolink:MolecularActivity ABC-type ferric-enterobactin transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in). EC:7.2.2.17|MetaCyc:ABC-10-RXN|RHEA:58492 go.json ATP-dependent ferric-enterobactin transmembrane transporter activity|ATPase-coupled ferric-enterobactin transmembrane transporter activity|ferric-enterobactin ABC transporter|ferric-enterobactin porter activity|ferric-enterobactin-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015624 GO:0015625 biolink:MolecularActivity ABC-type ferric hydroxamate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in). EC:7.2.2.16|MetaCyc:3.6.3.34-RXN|MetaCyc:ABC-11-RXN|MetaCyc:ABC-9-RXN go.json ATP-dependent ferric-hydroxamate transmembrane transporter activity|ATP-dependent iron-chelate transporter activity|ATPase-coupled ferric-hydroxamate transmembrane transporter activity|ATPase-coupled iron-chelate transporter activity|ferric-hydroxamate ABC transporter|ferric-hydroxamate porter activity|ferric-hydroxamate transmembrane transporter activity|ferric-hydroxamate-transporting ATPase activity|iron-chelate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0015625 GO:0015626 biolink:MolecularActivity L-diaminopimelate transmembrane transporter activity Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid. go.json L-diaminopimelate transporter activity|cystine/diaminopimelate porter activity http://purl.obolibrary.org/obo/GO_0015626 GO:0015620 biolink:MolecularActivity ferric-enterobactin transmembrane transporter activity Enables the transfer of ferric-enterobactin from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015620 GO:0015621 biolink:MolecularActivity ferric triacetylfusarinine C transmembrane transporter activity Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0015621 GO:0015622 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015622 GO:0050004 biolink:MolecularActivity isoflavone 7-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside. EC:2.4.1.170|MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN|RHEA:56344 go.json UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity|UDPglucose-flavonoid 7-O-glucosyltransferase activity|UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity|UDPglucose:isoflavone 7-O-glucosyltransferase activity|uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050004 GO:0050005 biolink:MolecularActivity isohexenylglutaconyl-CoA hydratase activity Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O. EC:4.2.1.57|KEGG_REACTION:R03493|MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN|RHEA:24144|UM-BBD_reactionID:r1167 go.json 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]|3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity|3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity|beta-isohexenylglutaconyl-CoA-hydratase activity|isohexenylglutaconyl coenzyme A hydratase activity http://purl.obolibrary.org/obo/GO_0050005 GO:0050002 biolink:MolecularActivity D-proline reductase (dithiol) activity Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline. EC:1.21.4.1|MetaCyc:1.21.4.1-RXN|RHEA:12737 go.json 5-aminopentanoate:lipoate oxidoreductase (cyclizing) http://purl.obolibrary.org/obo/GO_0050002 GO:0050003 biolink:MolecularActivity deoxycytidylate C-methyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate. EC:2.1.1.54|KEGG_REACTION:R01670|MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN|RHEA:11568 go.json 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity|dCMP methyltransferase activity|deoxycytidylate methyltransferase activity http://purl.obolibrary.org/obo/GO_0050003 GO:0050008 biolink:MolecularActivity isopiperitenone delta-isomerase activity Catalysis of the reaction: isopiperitenone = piperitenone. EC:5.3.3.11|KEGG_REACTION:R03782|MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN|RHEA:21516 go.json isopiperitenone D-isomerase activity|isopiperitenone delta8-delta4-isomerase activity http://purl.obolibrary.org/obo/GO_0050008 GO:0050009 biolink:MolecularActivity isopropanol dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + propan-2-ol = acetone + H+ + NADPH. EC:1.1.1.80|KEGG_REACTION:R01550|MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN|RHEA:21792 go.json propan-2-ol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050009 GO:0050006 biolink:MolecularActivity isomaltulose synthase activity Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose. EC:5.4.99.11|MetaCyc:ISOMALTULOSE-SYNTHASE-RXN|RHEA:24032 go.json isomaltulose synthetase activity|sucrose alpha-glucosyltransferase activity|sucrose glucosylmutase activity|trehalulose synthase activity http://purl.obolibrary.org/obo/GO_0050006 GO:0050007 biolink:MolecularActivity isonocardicin synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H+ + isonocardicin A. EC:2.5.1.38|KEGG_REACTION:R03072|MetaCyc:ISONOCARDICIN-SYNTHASE-RXN|RHEA:19845 go.json S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity|nocardicin aminocarboxypropyltransferase activity http://purl.obolibrary.org/obo/GO_0050007 GO:0050000 biolink:BiologicalProcess chromosome localization Any process in which a chromosome is transported to, or maintained in, a specific location. go.json chromosome localisation|establishment and maintenance of chromosome localization|establishment and maintenance of chromosome position http://purl.obolibrary.org/obo/GO_0050000 GO:0050001 biolink:MolecularActivity D-glutaminase activity Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate. EC:3.5.1.35|MetaCyc:D-GLUTAMINASE-RXN|RHEA:22840 go.json D-glutamine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050001 GO:0050015 biolink:MolecularActivity kievitone hydratase activity Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone. EC:4.2.1.95|KEGG_REACTION:R03622|MetaCyc:KIEVITONE-HYDRATASE-RXN|RHEA:23604 go.json KHase activity|kievitone-hydrate hydro-lyase (kievitone-forming)|kievitone-hydrate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050015 GO:0050016 biolink:MolecularActivity kynurenine 7,8-hydroxylase activity Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor. EC:1.14.99.2|MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN|RHEA:11968 go.json kynurenate 7,8-hydroxylase activity|kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)|kynurenic acid hydroxylase activity|kynurenic hydroxylase activity http://purl.obolibrary.org/obo/GO_0050016 GO:0050013 biolink:MolecularActivity 2-dehydropantoate aldolase activity Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde. EC:4.1.2.12|MetaCyc:KETOPANTOALDOLASE-RXN|RHEA:23276 go.json 2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)|2-dehydropantoate formaldehyde-lyase activity|ketopantoaldolase activity http://purl.obolibrary.org/obo/GO_0050013 GO:0050014 biolink:MolecularActivity ketotetrose-phosphate aldolase activity Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate. EC:4.1.2.2|KEGG_REACTION:R01014|MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN|RHEA:20932 go.json erythrose-1-phosphate synthase activity|erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)|erythrulose-1-phosphate formaldehyde-lyase activity|erythrulose-1-phosphate synthetase activity|phosphoketotetrose aldolase activity http://purl.obolibrary.org/obo/GO_0050014 GO:0050019 biolink:MolecularActivity L-arabinitol 4-dehydrogenase activity Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH. EC:1.1.1.12|KEGG_REACTION:R01903|MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN|RHEA:16381 go.json http://purl.obolibrary.org/obo/GO_0050019 GO:0050017 biolink:MolecularActivity L-3-cyanoalanine synthase activity Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine. EC:4.4.1.9|MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN|RHEA:17821 go.json L-cysteine hydrogen-sulfide-lyase (adding HCN)|L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)|beta-cyano-L-alanine synthase activity|beta-cyanoalanine synthase activity|beta-cyanoalanine synthetase activity http://purl.obolibrary.org/obo/GO_0050017 GO:0050018 biolink:MolecularActivity L-amino-acid dehydrogenase activity Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH. EC:1.4.1.5|MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN|RHEA:10396 go.json L-amino-acid:NAD+ oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0050018 GO:0015609 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015609 GO:0015605 biolink:MolecularActivity organophosphate ester transmembrane transporter activity Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. go.json http://purl.obolibrary.org/obo/GO_0015605 GO:0015606 biolink:MolecularActivity spermidine transmembrane transporter activity Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other. RHEA:35039 go.json http://purl.obolibrary.org/obo/GO_0015606 GO:0015607 biolink:MolecularActivity ABC-type fatty-acyl-CoA transporter activity Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) = ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it. EC:7.6.2.4|RHEA:15181 go.json ABC-type fatty-acyl-CoA transporter|ATPase-coupled fatty-acyl-CoA transmembrane transporter activity|fatty acyl CoA transporter activity|fatty-acyl-CoA transmembrane transporter activity|fatty-acyl-CoA-transporting ATPase http://purl.obolibrary.org/obo/GO_0015607 GO:0015608 biolink:MolecularActivity carbohydrate-importing ABC transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in). TC:3.A.1.1.1 go.json carbohydrate uptake transporter activity|carbohydrate-importing ATPase activity|sugar transporter http://purl.obolibrary.org/obo/GO_0015608 GO:0015601 biolink:MolecularActivity obsolete cystine/diaminopimelate porter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). go.json cystine/diaminopimelate porter activity True http://purl.obolibrary.org/obo/GO_0015601 GO:0015602 biolink:MolecularActivity obsolete leucine/isoleucine/valine porter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). go.json leucine/isoleucine/valine porter activity True http://purl.obolibrary.org/obo/GO_0015602 GO:0015603 biolink:MolecularActivity iron chelate transmembrane transporter activity Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. go.json http://purl.obolibrary.org/obo/GO_0015603 GO:0015604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015604 GO:0015600 biolink:MolecularActivity obsolete glutamate/aspartate porter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). go.json glutamate/aspartate porter activity True http://purl.obolibrary.org/obo/GO_0015600 GO:0050011 biolink:MolecularActivity itaconyl-CoA hydratase activity Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O. EC:4.2.1.56|MetaCyc:ITACONYL-COA-HYDRATASE-RXN|RHEA:13785 go.json citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)|citramalyl-CoA hydro-lyase activity|itaconyl coenzyme A hydratase activity http://purl.obolibrary.org/obo/GO_0050011 GO:0050012 biolink:MolecularActivity juglone 3-hydroxylase activity Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+. EC:1.17.3.4|KEGG_REACTION:R04327|MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN|RHEA:18745 go.json 5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)|juglone 3-monooxygenase activity|juglone hydroxylase activity|naphthoquinone hydroxylase activity http://purl.obolibrary.org/obo/GO_0050012 GO:0050010 biolink:MolecularActivity isovitexin beta-glucosyltransferase activity Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP. EC:2.4.1.106|KEGG_REACTION:R03686|MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:19529 go.json UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity|UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity|isovitexin b-glucosyltransferase activity|uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050010 GO:1990354 biolink:CellularComponent activated SUMO-E1 ligase complex A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins. go.json SUMO-SAE1/2 complex http://purl.obolibrary.org/obo/GO_1990354 GO:1990355 biolink:BiologicalProcess L-methionine salvage from methionine sulphoxide The generation of L-methionine from methionine sulphoxide. go.json methionine salvage from methionine sulphoxide http://purl.obolibrary.org/obo/GO_1990355 GO:1990356 biolink:CellularComponent obsolete sumoylated E2 ligase complex OBSOLETE. A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase. go.json True http://purl.obolibrary.org/obo/GO_1990356 GO:1990357 biolink:CellularComponent terminal web An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells. go.json http://purl.obolibrary.org/obo/GO_1990357 GO:1990350 biolink:CellularComponent glucose transporter complex A protein complex facilitating glucose transport into, out of or within a cell, or between cells. go.json http://purl.obolibrary.org/obo/GO_1990350 GO:0001099 biolink:MolecularActivity basal RNA polymerase II transcription machinery binding Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. go.json basal RNAP II transcription machinery binding http://purl.obolibrary.org/obo/GO_0001099 GO:1990351 biolink:CellularComponent transporter complex A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. go.json http://purl.obolibrary.org/obo/GO_1990351 GO:1990352 biolink:CellularComponent BRE1 E3 ubiquitin ligase complex A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes. go.json BRE1 E3 ubiquitin-protein ligase complex|BRE1 oligomer http://purl.obolibrary.org/obo/GO_1990352 GO:1990353 biolink:CellularComponent Fused-Smurf ubiquitin ligase complex A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation. go.json http://purl.obolibrary.org/obo/GO_1990353 GO:0001095 biolink:MolecularActivity TFIIE-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. go.json TFIIE-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001095 GO:0001096 biolink:MolecularActivity TFIIF-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. go.json TFIIF-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001096 GO:0001097 biolink:MolecularActivity TFIIH-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. go.json TFIIH-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001097 GO:0001098 biolink:MolecularActivity basal transcription machinery binding Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. go.json http://purl.obolibrary.org/obo/GO_0001098 GO:0001091 biolink:MolecularActivity RNA polymerase II general transcription initiation factor binding Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. go.json RNA polymerase II basal transcription factor binding http://purl.obolibrary.org/obo/GO_0001091 GO:0001092 biolink:MolecularActivity TFIIA-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. go.json TFIIA-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001092 GO:0001093 biolink:MolecularActivity TFIIB-class transcription factor binding Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. go.json http://purl.obolibrary.org/obo/GO_0001093 GO:0001094 biolink:MolecularActivity TFIID-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. go.json TFIID-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001094 GO:1990358 biolink:CellularComponent xylanosome A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose. go.json xylanolytic complex http://purl.obolibrary.org/obo/GO_1990358 GO:1990359 biolink:BiologicalProcess stress response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus. go.json response to zinc ion stress|response to zinc toxicity|stress response to zinc http://purl.obolibrary.org/obo/GO_1990359 GO:1990365 biolink:BiologicalProcess obsolete response to phenol OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phenols. go.json response to phenol True http://purl.obolibrary.org/obo/GO_1990365 GO:1990366 biolink:BiologicalProcess obsolete response to organic acid OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic acid. go.json response to organic acid True http://purl.obolibrary.org/obo/GO_1990366 GO:1990367 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990367 GO:1990368 biolink:BiologicalProcess obsolete process resulting in tolerance to hydrolysate OBSOLETE. A response that results in a state of tolerance to hydrolysate (product of hydrolysis). go.json process resulting in tolerance to hydrolysate True http://purl.obolibrary.org/obo/GO_1990368 GO:1990361 biolink:CellularComponent PKM2 pyruvate kinase complex A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013). go.json PKM2 homotetramer http://purl.obolibrary.org/obo/GO_1990361 GO:1990362 biolink:MolecularActivity butanol dehydrogenase activity Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+. RHEA:33199 go.json http://purl.obolibrary.org/obo/GO_1990362 GO:1990363 biolink:BiologicalProcess obsolete response to hydrolysate OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of hydrolysate (any product of hydrolysis). go.json response to hydrolysate True http://purl.obolibrary.org/obo/GO_1990363 GO:1990364 biolink:BiologicalProcess obsolete response to aldehyde OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde. go.json response to aldehyde True http://purl.obolibrary.org/obo/GO_1990364 GO:1990360 biolink:CellularComponent PKM2 protein kinase complex A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer. go.json PKM2-SAICAR complex|PKM2-SAICAR protein kinase complex http://purl.obolibrary.org/obo/GO_1990360 GO:0039698 biolink:BiologicalProcess polyadenylation of viral mRNA by polymerase stuttering Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail. VZ:1916 go.json polyA stuttering http://purl.obolibrary.org/obo/GO_0039698 GO:0039699 biolink:BiologicalProcess viral mRNA cap methylation An innate immune response evasion mechanism in which a virus methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs. go.json IFIT mRNA restriction evasion by virus http://purl.obolibrary.org/obo/GO_0039699 GO:0039692 biolink:BiologicalProcess single stranded viral RNA replication via double stranded DNA intermediate A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II. VZ:1937 go.json retroviral genome replication|viral ssRNA replication via dsDNA intermediate http://purl.obolibrary.org/obo/GO_0039692 GO:0039693 biolink:BiologicalProcess viral DNA genome replication The replication of a viral DNA genome. go.json DNA-dependent viral DNA replication|viral DNA replication|viral DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0039693 GO:0039690 biolink:BiologicalProcess positive stranded viral RNA replication A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA. VZ:1116 go.json ss(+) viral RNA replication http://purl.obolibrary.org/obo/GO_0039690 GO:0039691 biolink:BiologicalProcess double stranded viral RNA replication A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA. VZ:1936 go.json http://purl.obolibrary.org/obo/GO_0039691 GO:0039696 biolink:BiologicalProcess RNA-templated viral transcription A transcription process that uses viral RNA as a template. go.json http://purl.obolibrary.org/obo/GO_0039696 GO:1990369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990369 GO:0039697 biolink:BiologicalProcess negative stranded viral RNA transcription A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template. VZ:1096 go.json http://purl.obolibrary.org/obo/GO_0039697 GO:0039694 biolink:BiologicalProcess viral RNA genome replication The replication of a viral RNA genome. go.json http://purl.obolibrary.org/obo/GO_0039694 GO:0039695 biolink:BiologicalProcess DNA-templated viral transcription A transcription process that uses a viral DNA as a template. VZ:1942 go.json http://purl.obolibrary.org/obo/GO_0039695 GO:1990376 biolink:BiologicalProcess obsolete negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation that results in negative regulation of mitotic G1/S transition. go.json True http://purl.obolibrary.org/obo/GO_1990376 GO:1990377 biolink:CellularComponent organomineral extracellular matrix An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight. go.json http://purl.obolibrary.org/obo/GO_1990377 GO:1990378 biolink:CellularComponent upstream stimulatory factor complex A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters. go.json USF complex|USF1 homodimer|USF1-USF2 heterodimer|USF2 homodimer http://purl.obolibrary.org/obo/GO_1990378 GO:1990379 biolink:BiologicalProcess lipid transport across blood-brain barrier The directed movement of lipid molecules passing through the blood-brain barrier. go.json lipid transport across blood brain barrier http://purl.obolibrary.org/obo/GO_1990379 GO:1990372 biolink:BiologicalProcess obsolete process resulting in tolerance to organic acid OBSOLETE. A response that results in a state of tolerance to organic acid. go.json True http://purl.obolibrary.org/obo/GO_1990372 GO:0001077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001077 GO:0001078 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001078 GO:1990373 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990373 GO:1990374 biolink:CellularComponent Kir2 inward rectifier potassium channel complex A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells. go.json Kir2.1 complex http://purl.obolibrary.org/obo/GO_1990374 GO:0001079 biolink:BiologicalProcess nitrogen catabolite regulation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. go.json regulation of transcription from RNA polymerase II promoter by nitrogen catabolites http://purl.obolibrary.org/obo/GO_0001079 GO:1990375 biolink:BiologicalProcess baculum development The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure. go.json os penis development|penile bone development|penis bone development http://purl.obolibrary.org/obo/GO_1990375 GO:0001073 biolink:MolecularActivity transcription antitermination factor activity, DNA binding Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein. go.json DNA binding transcription antitermination factor activity http://purl.obolibrary.org/obo/GO_0001073 GO:0001074 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly OBSOLETE. Binding to a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter. go.json RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding involved in preinitiation complex assembly True http://purl.obolibrary.org/obo/GO_0001074 GO:1990370 biolink:BiologicalProcess obsolete process resulting in tolerance to aldehyde OBSOLETE. A response that results in a state of tolerance to aldehyde. go.json True http://purl.obolibrary.org/obo/GO_1990370 GO:0001075 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001075 GO:0001076 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase II transcription factor binding OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json RNA polymerase II transcription factor binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001076 GO:1990371 biolink:BiologicalProcess obsolete process resulting in tolerance to phenol OBSOLETE. A response that results in a state of tolerance to phenol. go.json True http://purl.obolibrary.org/obo/GO_1990371 GO:0001070 biolink:MolecularActivity RNA-binding transcription regulator activity A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences. go.json RNA binding transcription factor activity|RNA binding transcription regulator activity http://purl.obolibrary.org/obo/GO_0001070 GO:0001071 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001071 GO:0001072 biolink:MolecularActivity transcription antitermination factor activity, RNA binding Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein. go.json RNA binding transcription antitermination factor activity http://purl.obolibrary.org/obo/GO_0001072 GO:0039689 biolink:BiologicalProcess negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA). VZ:1096 go.json (-)ss viral RNA replication http://purl.obolibrary.org/obo/GO_0039689 GO:0039687 biolink:BiologicalProcess viral DNA strand displacement replication A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA). VZ:1940 go.json http://purl.obolibrary.org/obo/GO_0039687 GO:0039688 biolink:BiologicalProcess viral double stranded DNA replication via reverse transcription A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. VZ:1938 go.json RNA-dependent viral DNA replication|dsDNA replication via RNA intermediate|viral RNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0039688 GO:0039681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039681 GO:0039682 biolink:BiologicalProcess rolling circle viral DNA replication A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0039682 GO:0039680 biolink:BiologicalProcess actin-dependent intracellular transport of virus towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments. VZ:991 go.json actin-dependent intracellular transport of viral material towards nucleus|actin-dependent inwards viral transport http://purl.obolibrary.org/obo/GO_0039680 GO:0039685 biolink:BiologicalProcess rolling hairpin viral DNA replication A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA. VZ:2656 go.json ssDNA rolling hairpin viral DNA replication http://purl.obolibrary.org/obo/GO_0039685 GO:0039686 biolink:BiologicalProcess bidirectional double-stranded viral DNA replication A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions. VZ:1939 go.json viral bidirectional dsDNA replication http://purl.obolibrary.org/obo/GO_0039686 GO:0039683 biolink:BiologicalProcess rolling circle double-stranded viral DNA replication A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome. VZ:2676 go.json dsDNA rolling circle replication http://purl.obolibrary.org/obo/GO_0039683 GO:0039684 biolink:BiologicalProcess rolling circle single-stranded viral DNA replication A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome. VZ:1941 go.json ssDNA rolling circle replication http://purl.obolibrary.org/obo/GO_0039684 GO:1990387 biolink:BiologicalProcess isogloboside biosynthetic process The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides). go.json http://purl.obolibrary.org/obo/GO_1990387 GO:1990388 biolink:BiologicalProcess xylem-to-phloem iron transport The directed movement of iron ions into the phloem from the xylem. go.json http://purl.obolibrary.org/obo/GO_1990388 GO:1990389 biolink:CellularComponent CUE1-UBC7 ubiquitin-conjugating enzyme complex A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1. go.json CUE1-UBC7 ubiquitin-conjugating enzyme (E2) http://purl.obolibrary.org/obo/GO_1990389 GO:0001088 biolink:MolecularActivity obsolete transcription factor activity, TFIIE-class binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TFIIE-class binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001088 GO:1990383 biolink:BiologicalProcess cellular response to biotin starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin. go.json http://purl.obolibrary.org/obo/GO_1990383 GO:1990384 biolink:BiologicalProcess hyaloid vascular plexus regression The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression. go.json http://purl.obolibrary.org/obo/GO_1990384 GO:0001089 biolink:MolecularActivity obsolete transcription factor activity, TFIIF-class transcription factor binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TFIIF-class binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001089 GO:1990385 biolink:CellularComponent meiotic spindle midzone The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap. go.json http://purl.obolibrary.org/obo/GO_1990385 GO:1990386 biolink:BiologicalProcess mitotic cleavage furrow ingression Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. go.json http://purl.obolibrary.org/obo/GO_1990386 GO:0001084 biolink:MolecularActivity obsolete transcription factor activity, TFIID-class binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TFIID-class binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001084 GO:1990380 biolink:MolecularActivity K48-linked deubiquitinase activity Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin. Reactome:R-HSA-5690870|Reactome:R-HSA-9711058 go.json K48-specific deubiquitinase activity|K48-specific deubiquitinating activity|Lys48-specific deubiquitinase activity http://purl.obolibrary.org/obo/GO_1990380 GO:0001085 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001085 GO:1990381 biolink:MolecularActivity ubiquitin-specific protease binding Binding to a ubiquitin-specific protease. go.json deubiquitinase binding|deubiquitinating enzyme binding http://purl.obolibrary.org/obo/GO_1990381 GO:0001086 biolink:MolecularActivity obsolete transcription factor activity, TFIIA-class binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TFIIA-class binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001086 GO:0001087 biolink:MolecularActivity obsolete transcription factor activity, TFIIB-class binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TFIIB-class binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001087 GO:1990382 biolink:BiologicalProcess obsolete melanosome assembly OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. go.json melanosome biogenesis True http://purl.obolibrary.org/obo/GO_1990382 GO:0001080 biolink:BiologicalProcess nitrogen catabolite activation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. go.json positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites http://purl.obolibrary.org/obo/GO_0001080 GO:0001081 biolink:BiologicalProcess nitrogen catabolite repression of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. go.json negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites http://purl.obolibrary.org/obo/GO_0001081 GO:0001082 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase I transcription factor binding OBSOLETE. Binding to an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json RNA polymerase I transcription factor binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001082 GO:0001083 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase II basal transcription factor binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json RNA polymerase II basal transcription factor binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001083 GO:0039678 biolink:BiologicalProcess viral genome ejection through host cell envelope Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm. go.json phage genome ejection|viral genome injection through bacterial membranes http://purl.obolibrary.org/obo/GO_0039678 GO:0039679 biolink:CellularComponent viral occlusion body A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host. VZ:1949 go.json http://purl.obolibrary.org/obo/GO_0039679 GO:0039676 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039676 GO:0001090 biolink:MolecularActivity obsolete transcription factor activity, TFIIH-class binding OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TFIIH-class binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001090 GO:0039677 biolink:BiologicalProcess exit of virus from host cell nucleus via nuclear envelope disassembly The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus. VZ:2176 go.json exit of virus from host cell nucleus via nuclear envelope breakdown http://purl.obolibrary.org/obo/GO_0039677 GO:0039670 biolink:CellularComponent viral capsid, turret A turret-like appendage formed at the vertices of an icosahedral capsid. go.json http://purl.obolibrary.org/obo/GO_0039670 GO:0039671 biolink:BiologicalProcess evasion by virus of host natural killer cell activity Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells. go.json evasion by virus of host NK cell killing|evasion by virus of host natural killer cell response|modulation of host NK-cell activity by virus|protection by virus against host NK cell cytotoxicity|suppression by virus of host natural killer cell function|viral immunoevasion of host NK cell http://purl.obolibrary.org/obo/GO_0039671 GO:0039674 biolink:BiologicalProcess exit of virus from host cell nucleus The directed movement of the viral genome or a viral particle out of the host cell nucleus. VZ:2177 go.json http://purl.obolibrary.org/obo/GO_0039674 GO:0039675 biolink:BiologicalProcess exit of virus from host cell nucleus through nuclear pore The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore. VZ:1953 go.json exit of virus from host cell nucleus through nuclear pore complex|nuclear pore exit of virus|viral enome export through nuclear pore http://purl.obolibrary.org/obo/GO_0039675 GO:0039672 biolink:BiologicalProcess suppression by virus of host natural killer cell activation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host. go.json suppression by virus of host NK-cell activation http://purl.obolibrary.org/obo/GO_0039672 GO:0039673 biolink:BiologicalProcess evasion by virus of host dendritic cell activity Any process by which a virus avoids the effects mediated by the host organism's dendritic cells. go.json evasion by virus of host dendritic cell response|impairing dendritic cell function by virus|modulation of host dendritic cell activity by virus http://purl.obolibrary.org/obo/GO_0039673 GO:1990310 biolink:MolecularActivity type-III dockerin domain binding Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain. go.json http://purl.obolibrary.org/obo/GO_1990310 GO:0001059 biolink:BiologicalProcess transcription by RNA polymerase IV The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter. go.json transcription from RNA pol IV promoter|transcription from RNA polymerase IV promoter http://purl.obolibrary.org/obo/GO_0001059 GO:1990311 biolink:MolecularActivity type-I cohesin domain binding Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain. go.json http://purl.obolibrary.org/obo/GO_1990311 GO:1990312 biolink:MolecularActivity type-II cohesin domain binding Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain. go.json http://purl.obolibrary.org/obo/GO_1990312 GO:1990313 biolink:MolecularActivity type-III cohesin domain binding Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain. go.json http://purl.obolibrary.org/obo/GO_1990313 GO:0001055 biolink:MolecularActivity RNA polymerase II activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. Reactome:R-HSA-6814549|Reactome:R-HSA-6814559 go.json DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0001055 GO:0001056 biolink:MolecularActivity RNA polymerase III activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. Reactome:R-HSA-1964482 go.json DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0001056 GO:0001057 biolink:MolecularActivity RNA polymerase IV activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter http://purl.obolibrary.org/obo/GO_0001057 GO:0001058 biolink:MolecularActivity RNA polymerase V activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter http://purl.obolibrary.org/obo/GO_0001058 GO:0001051 biolink:MolecularActivity plastid single-subunit type RNA polymerase binding Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. go.json http://purl.obolibrary.org/obo/GO_0001051 GO:0001052 biolink:MolecularActivity plastid PEP RNA polymerase core enzyme binding Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit. go.json http://purl.obolibrary.org/obo/GO_0001052 GO:0001053 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001053 GO:0001054 biolink:MolecularActivity RNA polymerase I activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter http://purl.obolibrary.org/obo/GO_0001054 GO:0001050 biolink:MolecularActivity single-subunit type RNA polymerase binding Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. go.json SP6-type RNA polymerase binding|T3-type RNA polymerase binding|T3/T7 type RNA polymerase binding|T7-type RNA polymerase binding http://purl.obolibrary.org/obo/GO_0001050 GO:0039667 biolink:BiologicalProcess viral entry into host cell via pilus retraction The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus. go.json http://purl.obolibrary.org/obo/GO_0039667 GO:0039668 biolink:BiologicalProcess viral entry into host cell via pilus basal pore The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way. go.json filamentous viral entry into host cell via pilus retraction http://purl.obolibrary.org/obo/GO_0039668 GO:0039665 biolink:BiologicalProcess permeabilization of host organelle membrane involved in viral entry into host cell Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm. VZ:985 go.json viral entry into host cell via permeabilization of host organelle membrane|viral membrane-penetration protein|viral penetration via host endosomal membrane disruption by virus|viral penetration via perforation of host organellar membrane by virus|viral penetration via permeabilization of host organellar membrane http://purl.obolibrary.org/obo/GO_0039665 GO:0039666 biolink:BiologicalProcess virion attachment to host cell pilus The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side. VZ:981 go.json pilus-adsorption protein|pilus-mediated viral adsorption onto host cell|pilus-mediated viral attachment to host cell|viral attachment to host cell pilus http://purl.obolibrary.org/obo/GO_0039666 GO:0015696 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015696 GO:0015697 biolink:BiologicalProcess quaternary ammonium group transport The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. go.json quaternary amine transport|quaternary ammonium compound transport http://purl.obolibrary.org/obo/GO_0015697 GO:0039669 biolink:BiologicalProcess viral entry into host cell via pilus retraction and membrane fusion The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane. go.json http://purl.obolibrary.org/obo/GO_0039669 GO:0015698 biolink:BiologicalProcess inorganic anion transport The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. go.json http://purl.obolibrary.org/obo/GO_0015698 GO:0015699 biolink:BiologicalProcess antimonite transport The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015699 GO:0015692 biolink:BiologicalProcess lead ion transport The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015692 GO:1990318 biolink:CellularComponent collagen type XIX trimer A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells. go.json http://purl.obolibrary.org/obo/GO_1990318 GO:1990319 biolink:CellularComponent collagen type XX trimer A collagen homotrimer of alpha1(XX) chains. go.json http://purl.obolibrary.org/obo/GO_1990319 GO:0039660 biolink:MolecularActivity structural constituent of virion The action of a molecule that contributes to the structural integrity of a virion. go.json viral matrix protein http://purl.obolibrary.org/obo/GO_0039660 GO:0015693 biolink:BiologicalProcess magnesium ion transport The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json magnesium transport http://purl.obolibrary.org/obo/GO_0015693 GO:0015694 biolink:BiologicalProcess mercury ion transport The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json mercuric ion transport|mercury transport http://purl.obolibrary.org/obo/GO_0015694 GO:0015695 biolink:BiologicalProcess organic cation transport The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. go.json http://purl.obolibrary.org/obo/GO_0015695 GO:1990314 biolink:BiologicalProcess cellular response to insulin-like growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. go.json cellular response to insulin-like growth factor http://purl.obolibrary.org/obo/GO_1990314 GO:0039663 biolink:BiologicalProcess membrane fusion involved in viral entry into host cell Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell. go.json fusion of virus membrane with host membrane|fusion of virus membrane with host membrane during viral entry|viral entry into host cell via membrane fusion http://purl.obolibrary.org/obo/GO_0039663 GO:0039664 biolink:BiologicalProcess lysis of host organelle involved in viral entry into host cell The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm. VZ:984 go.json viral entry into host cell via endosome membrane lysis|viral entry into host cell via lysis of host organelle membrane|viral membrane-lytic protein|viral penetration via lysis of host organellar membrane http://purl.obolibrary.org/obo/GO_0039664 GO:1990315 biolink:CellularComponent Mcs4 RR-MAPKKK complex A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress. go.json http://purl.obolibrary.org/obo/GO_1990315 GO:0039661 biolink:CellularComponent host organelle outer membrane The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell. go.json http://purl.obolibrary.org/obo/GO_0039661 GO:0015690 biolink:BiologicalProcess aluminum cation transport The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json aluminium ion transport|aluminium transport|aluminum ion transport|aluminum transport http://purl.obolibrary.org/obo/GO_0015690 GO:1990316 biolink:CellularComponent Atg1/ULK1 kinase complex A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. go.json ATG1 kinase complex|ATG1-ATG13 complex|ATG1/ULK1 signaling complex|Atg1p signalling complex|ULK complex|ULK1 complex|ULK1 signaling complex|ULK1-ATG13-FIP200 complex|ULK1-ATG13-RB1CC1 complex|autophagy-initiation complex http://purl.obolibrary.org/obo/GO_1990316 GO:1990317 biolink:CellularComponent Gin4 complex A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved. go.json Gin4-septin complex http://purl.obolibrary.org/obo/GO_1990317 GO:0039662 biolink:CellularComponent host cell outer membrane A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell. go.json host cell envelope outer membrane|outer membrane of host cell http://purl.obolibrary.org/obo/GO_0039662 GO:0015691 biolink:BiologicalProcess cadmium ion transport The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json cadmium transport http://purl.obolibrary.org/obo/GO_0015691 GO:1990321 biolink:CellularComponent collagen type XXII trimer A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. go.json http://purl.obolibrary.org/obo/GO_1990321 GO:1990322 biolink:CellularComponent collagen type XXIII trimer A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1990322 GO:1990323 biolink:CellularComponent collagen type XXIV trimer A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. go.json http://purl.obolibrary.org/obo/GO_1990323 GO:1990324 biolink:CellularComponent collagen type XXVI trimer A collagen homotrimer of alpha1(XXVI) chains. go.json http://purl.obolibrary.org/obo/GO_1990324 GO:0001066 biolink:MolecularActivity plastid single subunit type RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json http://purl.obolibrary.org/obo/GO_0001066 GO:0001067 biolink:MolecularActivity transcription regulatory region nucleic acid binding Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. go.json regulatory region nucleic acid binding http://purl.obolibrary.org/obo/GO_0001067 GO:0001068 biolink:MolecularActivity transcription regulatory region RNA binding Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon. go.json http://purl.obolibrary.org/obo/GO_0001068 GO:1990320 biolink:CellularComponent collagen type XXI trimer A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle. go.json http://purl.obolibrary.org/obo/GO_1990320 GO:0001069 biolink:MolecularActivity regulatory region RNA binding Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. go.json http://purl.obolibrary.org/obo/GO_0001069 GO:0001062 biolink:MolecularActivity obsolete plastid PEP-A RNA polymerase activity OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json True http://purl.obolibrary.org/obo/GO_0001062 GO:0001063 biolink:MolecularActivity obsolete plastid PEP-B RNA polymerase activity OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json True http://purl.obolibrary.org/obo/GO_0001063 GO:0001064 biolink:MolecularActivity single subunit type RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json T3/T7 type RNA polymerase activity http://purl.obolibrary.org/obo/GO_0001064 GO:0001065 biolink:MolecularActivity mitochondrial single subunit type RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json http://purl.obolibrary.org/obo/GO_0001065 GO:0001060 biolink:BiologicalProcess transcription by RNA polymerase V The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter. go.json transcription from RNA pol V promoter|transcription from RNA polymerase V promoter http://purl.obolibrary.org/obo/GO_0001060 GO:0001061 biolink:MolecularActivity obsolete bacterial-type RNA polymerase activity OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. go.json True http://purl.obolibrary.org/obo/GO_0001061 GO:0039656 biolink:BiologicalProcess modulation by virus of host gene expression The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. go.json regulation by virus of host gene expression http://purl.obolibrary.org/obo/GO_0039656 GO:0039657 biolink:BiologicalProcess suppression by virus of host gene expression Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. VZ:1582 go.json host gene expression shutoff by virus http://purl.obolibrary.org/obo/GO_0039657 GO:0039654 biolink:BiologicalProcess fusion of virus membrane with host endosome membrane Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell. VZ:992 go.json fusion of virus membrane with host endosomal membrane|viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane|viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane|viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane|viral entry into host cell via endocytosis followed by membrane fusion with host endosome|viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane|viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane|viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane http://purl.obolibrary.org/obo/GO_0039654 GO:0039655 biolink:BiologicalProcess obsolete transport of virus in host, cell to cell via plasmodesmata OBSOLETE. The transport of a virus between adjacent cells in a multicellular organism using plasmodesmata. Plasmodesma is a fine cytoplasmic channel found in all higher plants, which connects the cytoplasm of one cell to that of an adjacent cell. VZ:1018 go.json spread of virus in host, cell to cell via plasmodesmata|viral movement protein True http://purl.obolibrary.org/obo/GO_0039655 GO:0039658 biolink:CellularComponent TBK1-IKKE-DDX3 complex A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3. go.json TBK1-IKBKE-DDX3 complex http://purl.obolibrary.org/obo/GO_0039658 GO:0039659 biolink:BiologicalProcess obsolete suppression by virus of host TBK1-IKBKE-DDX3 complex activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TBK1-IKBKE-DDX3 complex. VZ:719 go.json inhibition of host TBK1-IKBKE-DDX3 complex by virus|suppression by virus of host TBK1-IKKE-DDX3 complex activity True http://purl.obolibrary.org/obo/GO_0039659 GO:1990329 biolink:CellularComponent IscS-TusA complex A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups. go.json http://purl.obolibrary.org/obo/GO_1990329 GO:0039652 biolink:BiologicalProcess induction by virus of host NF-kappaB cascade A process in which a virus initiates, promotes, or enhances a host NF-kappaB signaling cascade. VZ:841 go.json activation by virus of host NF-kappaB transcription factor activity|activation of host NF-kappa-B by virus http://purl.obolibrary.org/obo/GO_0039652 GO:1990325 biolink:CellularComponent collagen type XXVII trimer A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone. go.json http://purl.obolibrary.org/obo/GO_1990325 GO:0039653 biolink:BiologicalProcess suppression by virus of host transcription Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors. VZ:1577 go.json host transcription shutoff by virus|suppression by virus of host DNA-dependent transcription http://purl.obolibrary.org/obo/GO_0039653 GO:1990326 biolink:CellularComponent collagen type XXVIII trimer A collagen homotrimer of alpha1(XXVIII) chains. go.json http://purl.obolibrary.org/obo/GO_1990326 GO:0039650 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039650 GO:1990327 biolink:CellularComponent collagen type XXV trimer A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1990327 GO:0039651 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0039651 GO:1990328 biolink:CellularComponent RPB4-RPB7 complex A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways. go.json RNA polymerase II, RPB4-RPB7 subcomplex http://purl.obolibrary.org/obo/GO_1990328 GO:1990332 biolink:CellularComponent Ire1 complex A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. go.json ERN1 complex|IRE1 dimer http://purl.obolibrary.org/obo/GO_1990332 GO:0001037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001037 GO:1990333 biolink:CellularComponent mitotic checkpoint complex, CDC20-MAD2 subcomplex A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20. go.json CDC20-MAD2 complex http://purl.obolibrary.org/obo/GO_1990333 GO:0001038 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001038 GO:1990334 biolink:CellularComponent Bfa1-Bub2 complex A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. go.json http://purl.obolibrary.org/obo/GO_1990334 GO:0001039 biolink:MolecularActivity RNA polymerase III hybrid type promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene. go.json RNA polymerase III hybrid type promoter DNA binding http://purl.obolibrary.org/obo/GO_0001039 GO:1990335 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990335 GO:0001033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001033 GO:0001034 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001034 GO:0001035 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001035 GO:1990330 biolink:CellularComponent IscS-IscU complex A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group. go.json http://purl.obolibrary.org/obo/GO_1990330 GO:1990331 biolink:CellularComponent Hpa2 acetyltransferase complex A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules. go.json http://purl.obolibrary.org/obo/GO_1990331 GO:0001036 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001036 GO:0001030 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001030 GO:0001031 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001031 GO:0001032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001032 GO:0039645 biolink:BiologicalProcess perturbation by virus of host G1/S transition checkpoint A process in which a virus interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction. VZ:880 go.json G1/S host cell cycle checkpoint dysregulation by virus|modulation by virus of host G1/S transition checkpoint http://purl.obolibrary.org/obo/GO_0039645 GO:0015678 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015678 GO:0039646 biolink:BiologicalProcess perturbation by virus of host G0/G1 transition checkpoint A process in which a virus interferes with the normal execution of the host cell G0/G1 transition checkpoint. VZ:881 go.json G0/G1 host cell cycle checkpoint dysregulation by virus|modulation by virus of host G0/G1 transition checkpoint http://purl.obolibrary.org/obo/GO_0039646 GO:0015679 biolink:BiologicalProcess plasma membrane copper ion transport The directed movement of copper ions across the plasma membrane. go.json plasma membrane copper transport http://purl.obolibrary.org/obo/GO_0015679 GO:0039643 biolink:CellularComponent host cell viral nucleoid The region of a host cell that contains the viral genome. go.json http://purl.obolibrary.org/obo/GO_0039643 GO:0039644 biolink:BiologicalProcess suppression by virus of host NF-kappaB cascade Any process in which a virus stops, prevents, or reduces a host NF-kappaB cascade. go.json inhibition of host NF-kappa-B by virus|suppression by virus of host NF-kappaB transcription factor activity http://purl.obolibrary.org/obo/GO_0039644 GO:0015674 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015674 GO:0039649 biolink:BiologicalProcess obsolete modulation by virus of host ubiquitin-protein ligase activity OBSOLETE. The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. go.json modulation of host E3 ubiquitin ligases by virus True http://purl.obolibrary.org/obo/GO_0039649 GO:0015675 biolink:BiologicalProcess nickel cation transport The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015675 GO:0039647 biolink:BiologicalProcess obsolete suppression by virus of host poly(A)-binding protein activity OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation. go.json inhibition of host poly(A)-binding protein by virus|suppression by virus of host PABP activity True http://purl.obolibrary.org/obo/GO_0039647 GO:0015676 biolink:BiologicalProcess vanadium ion transport The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015676 GO:0039648 biolink:BiologicalProcess modulation by symbiont of host protein ubiquitination Any process by which a symbiont increases or decreases ubiquitination of target proteins of a host organism. go.json modulation of host ubiquitin pathway by virus http://purl.obolibrary.org/obo/GO_0039648 GO:0015677 biolink:BiologicalProcess copper ion import The directed movement of copper ions into a cell or organelle. go.json copper ion uptake http://purl.obolibrary.org/obo/GO_0015677 GO:0015670 biolink:BiologicalProcess carbon dioxide transport The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015670 GO:0015671 biolink:BiologicalProcess oxygen transport The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015671 GO:0015672 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015672 GO:0015673 biolink:BiologicalProcess silver ion transport The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json silver transport http://purl.obolibrary.org/obo/GO_0015673 GO:0039641 biolink:CellularComponent viral inner membrane The lipid bilayer of a virion contained inside the protein capsid. go.json virion inner membrane http://purl.obolibrary.org/obo/GO_0039641 GO:1990336 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990336 GO:0039642 biolink:CellularComponent virion nucleoid The region of a virion in which the nucleic acid is confined. go.json http://purl.obolibrary.org/obo/GO_0039642 GO:1990337 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990337 GO:1990338 biolink:CellularComponent laminin-14 complex A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains. go.json laminin-423 http://purl.obolibrary.org/obo/GO_1990338 GO:0039640 biolink:BiologicalProcess viral release via suppression of host peptidoglycan biosynthetic process The dissemination of mature viral particles from a host cell, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. go.json cytolysis by virus via suppression of host peptidoglycan biosynthetic process|viral exit by cytolysis via suppression of host peptidoglycan biosynthetic process|viral release by cytolysis via suppression of host peptidoglycan biosynthetic process http://purl.obolibrary.org/obo/GO_0039640 GO:1990339 biolink:CellularComponent laminin-522 complex A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains. go.json laminin-522 http://purl.obolibrary.org/obo/GO_1990339 GO:1990343 biolink:CellularComponent heterochromatin domain A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me). go.json HOOD http://purl.obolibrary.org/obo/GO_1990343 GO:0001048 biolink:MolecularActivity RNA polymerase IV core binding Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production. go.json http://purl.obolibrary.org/obo/GO_0001048 GO:1990344 biolink:BiologicalProcess secondary cell septum biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division. go.json http://purl.obolibrary.org/obo/GO_1990344 GO:0001049 biolink:MolecularActivity RNA polymerase V core binding Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing. go.json http://purl.obolibrary.org/obo/GO_0001049 GO:1990345 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990345 GO:1990346 biolink:CellularComponent BID-BCL-xl complex A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_1990346 GO:0001044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001044 GO:1990340 biolink:CellularComponent laminin-15 complex A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains. go.json laminin-523 http://purl.obolibrary.org/obo/GO_1990340 GO:0001045 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001045 GO:0001046 biolink:MolecularActivity core promoter sequence-specific DNA binding Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. go.json bacterial-type RNA polymerase core promoter sequence-specific DNA binding|core promoter binding|eubacterial-type RNA polymerase core promoter sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001046 GO:1990341 biolink:CellularComponent thrombospondin complex A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour. go.json http://purl.obolibrary.org/obo/GO_1990341 GO:0001047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001047 GO:1990342 biolink:CellularComponent heterochromatin island A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi. go.json http://purl.obolibrary.org/obo/GO_1990342 GO:0001040 biolink:MolecularActivity obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex. go.json True http://purl.obolibrary.org/obo/GO_0001040 GO:0001041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001041 GO:0001042 biolink:MolecularActivity RNA polymerase I core binding Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. go.json http://purl.obolibrary.org/obo/GO_0001042 GO:0001043 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001043 GO:0039634 biolink:BiologicalProcess killing by virus of host cell during superinfection exclusion The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus. go.json Rex exclusion|killing by virus of host cells during superinfection exclusion|killing by virus of host cells involved in superinfection exclusion http://purl.obolibrary.org/obo/GO_0039634 GO:0015689 biolink:BiologicalProcess molybdate ion transport The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. go.json http://purl.obolibrary.org/obo/GO_0015689 GO:0039635 biolink:BiologicalProcess suppression by virus of host peptidoglycan biosynthetic process Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. go.json viral inhibition of host peptidoglycan biosynthesis http://purl.obolibrary.org/obo/GO_0039635 GO:0039632 biolink:MolecularActivity obsolete RNA translocase activity involved in viral RNA genome packaging OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid. go.json RNA packaging ATPase activity|viral RNA packaging activity True http://purl.obolibrary.org/obo/GO_0039632 GO:0039633 biolink:BiologicalProcess obsolete killing by virus of host cell OBSOLETE. Any process mediated by a virus that results in the death of a cell in the host organism. go.json killing by phage of host cells|killing by virus of host cells True http://purl.obolibrary.org/obo/GO_0039633 GO:0015685 biolink:BiologicalProcess ferric-enterobactin import into cell A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors. go.json ferric-enterobactin transport http://purl.obolibrary.org/obo/GO_0015685 GO:0039638 biolink:BiologicalProcess lipopolysaccharide-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface. go.json LPS binding involved in viral attachment to host cell|lipopolysaccharide binding involved in viral attachment to host cell|virion attachment, binding to host lipopolysaccharide http://purl.obolibrary.org/obo/GO_0039638 GO:0039639 biolink:BiologicalProcess suppression by virus of host cell lysis in response to superinfection The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus. go.json lysis inhibition|suppression by virus of host cell lysis in response to superinfecting virus http://purl.obolibrary.org/obo/GO_0039639 GO:0015686 biolink:BiologicalProcess ferric triacetylfusarinine C import into cell The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json ferric triacetylfusarinine C transport http://purl.obolibrary.org/obo/GO_0015686 GO:0039636 biolink:BiologicalProcess suppression by virus of host cell wall biogenesis Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts. go.json http://purl.obolibrary.org/obo/GO_0039636 GO:0015687 biolink:BiologicalProcess ferric-hydroxamate import into cell A process in which ferric-hydroxamate, the iron-bound form of the iron chelator hydroxamate, is transported into the cell by specific cell surface receptors. go.json ferric-hydroxamate transport http://purl.obolibrary.org/obo/GO_0015687 GO:0039637 biolink:BiologicalProcess catabolism by virus of host DNA The breakdown of host DNA, deoxyribonucleic acid, by a virus. go.json http://purl.obolibrary.org/obo/GO_0039637 GO:0015688 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015688 GO:0015681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015681 GO:0015682 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015682 GO:0015683 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015683 GO:0015684 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015684 GO:1990347 biolink:MolecularActivity obsolete G*/A mismatch-specific adenine-DNA glycosylase activity OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite 8-oxoG in the template by adenine DNA glycosylase activity. The reaction leaves an apyrimidinic (AP) site. go.json G*/A mismatch-specific adenine-DNA glycosylase activity True http://purl.obolibrary.org/obo/GO_1990347 GO:0039630 biolink:MolecularActivity RNA translocase activity Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0039630 GO:1990348 biolink:MolecularActivity obsolete G/A mismatch specific adenine DNA glycosylase activity OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite guanine in the template by adenine DNA glycosylase activity. The reaction leaves an apurinic AP site. I also requested same term but for Go/A mismatch. If you think it is better to make one term for mismatched adenine that is fine by me. go.json G/A mismatch specific adenine DNA glycosylase activity True http://purl.obolibrary.org/obo/GO_1990348 GO:0039631 biolink:MolecularActivity obsolete DNA translocase activity involved in viral DNA genome packaging OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid. go.json viral DNA packaging activity|viral DNA packaging motor activity True http://purl.obolibrary.org/obo/GO_0039631 GO:1990349 biolink:BiologicalProcess gap junction-mediated intercellular transport The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells. go.json http://purl.obolibrary.org/obo/GO_1990349 GO:0015680 biolink:BiologicalProcess protein maturation by copper ion transfer A process that contributes to the delivery of copper ions to a target protein. go.json intracellular copper delivery|intracellular copper ion delivery|intracellular copper ion transport http://purl.obolibrary.org/obo/GO_0015680 GO:1990300 biolink:MolecularActivity cellulosome binding Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides. go.json scaffoldin complex binding http://purl.obolibrary.org/obo/GO_1990300 GO:1990301 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990301 GO:1990302 biolink:CellularComponent Bre1-Rad6 ubiquitin ligase complex A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis. go.json Bre1-Rad6 complex http://purl.obolibrary.org/obo/GO_1990302 GO:1990307 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990307 GO:1990308 biolink:MolecularActivity type-I dockerin domain binding Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain. go.json http://purl.obolibrary.org/obo/GO_1990308 GO:1990309 biolink:MolecularActivity type-II dockerin domain binding Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain. go.json http://purl.obolibrary.org/obo/GO_1990309 GO:1990303 biolink:CellularComponent UBR1-RAD6 ubiquitin ligase complex A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. go.json UBR1-RAD6 complex http://purl.obolibrary.org/obo/GO_1990303 GO:1990304 biolink:CellularComponent MUB1-RAD6-UBR2 ubiquitin ligase complex A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. go.json http://purl.obolibrary.org/obo/GO_1990304 GO:1990305 biolink:CellularComponent RAD6-UBR2 ubiquitin ligase complex A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation. go.json RAD6-UBR2 complex http://purl.obolibrary.org/obo/GO_1990305 GO:1990306 biolink:CellularComponent RSP5-BUL ubiquitin ligase complex A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation. go.json RSP5-BUL1 complex|RSP5-BUL2 complex http://purl.obolibrary.org/obo/GO_1990306 GO:0050147 biolink:MolecularActivity nucleoside ribosyltransferase activity Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1. EC:2.4.2.5|MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN go.json nucleoside N-ribosyltransferase activity|nucleoside:purine(pyrimidine) D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0050147 GO:0050148 biolink:MolecularActivity nucleotide diphosphokinase activity Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate. EC:2.7.6.4|MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN|RHEA:12713 go.json ATP nucleotide 3'-pyrophosphokinase activity|ATP:nucleoside-5'-phosphate diphosphotransferase activity|ATP:nucleotide pyrophosphotransferase activity|nucleotide 3'-pyrophosphokinase activity|nucleotide pyrophosphokinase activity http://purl.obolibrary.org/obo/GO_0050148 GO:0050145 biolink:MolecularActivity nucleoside monophosphate kinase activity Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. EC:2.7.4.4|MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN|RHEA:24036|Reactome:R-HSA-2162092|Reactome:R-HSA-6788798|Reactome:R-HSA-6788810|Reactome:R-HSA-73548|Reactome:R-HSA-73635|Reactome:R-HSA-75125|Reactome:R-HSA-75126|Reactome:R-HSA-9754978 go.json ATP:nucleoside-phosphate phosphotransferase activity|NMP-kinase activity|nucleoside-phosphate kinase activity|nucleotide kinase activity http://purl.obolibrary.org/obo/GO_0050145 GO:0050146 biolink:MolecularActivity nucleoside phosphotransferase activity Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate. EC:2.7.1.77|MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN|RHEA:19961|Reactome:R-HSA-2162066|Reactome:R-HSA-9754916 go.json nonspecific nucleoside phosphotransferase activity|nucleotide:2'-nucleoside 5'-phosphotransferase activity|nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity|nucleotide:nucleoside 5'-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050146 GO:0050149 biolink:MolecularActivity o-aminophenol oxidase activity Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O. EC:1.10.3.4|MetaCyc:O-AMINOPHENOL-OXIDASE-RXN|RHEA:40963 go.json 2-aminophenol:O2 oxidoreductase activity|2-aminophenol:oxygen oxidoreductase activity|GriF|isophenoxazine synthase activity|o-aminophenol:O2 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050149 GO:0015818 biolink:BiologicalProcess isoleucine transport The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-isoleucine transport http://purl.obolibrary.org/obo/GO_0015818 GO:0015819 biolink:BiologicalProcess lysine transport The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-lysine import|L-lysine transport|lysine import|lysine uptake http://purl.obolibrary.org/obo/GO_0015819 GO:0015814 biolink:BiologicalProcess p-aminobenzoyl-glutamate transport The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015814 GO:0015815 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015815 GO:0015816 biolink:BiologicalProcess glycine transport The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015816 GO:0015817 biolink:BiologicalProcess histidine transport The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-histidine transport http://purl.obolibrary.org/obo/GO_0015817 GO:0015810 biolink:BiologicalProcess aspartate transmembrane transport The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other. go.json aspartate transport|mitochondrial aspartate/glutamate transport http://purl.obolibrary.org/obo/GO_0015810 GO:0015811 biolink:BiologicalProcess L-cystine transport The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015811 GO:0015812 biolink:BiologicalProcess gamma-aminobutyric acid transport The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 4-aminobutanoate transport|4-aminobutyrate transport|GABA transport http://purl.obolibrary.org/obo/GO_0015812 GO:0015813 biolink:BiologicalProcess L-glutamate transmembrane transport The directed movement of L-glutamate across a membrane. go.json L-glutamate transport|mitochondrial aspartate/glutamate transport http://purl.obolibrary.org/obo/GO_0015813 GO:0050140 biolink:MolecularActivity nitrate reductase (cytochrome) activity Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite. EC:1.9.6.1|MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN|RHEA:12909 go.json benzyl viologen-nitrate reductase activity|ferrocytochrome:nitrate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050140 GO:0050143 biolink:MolecularActivity nocardicin-A epimerase activity Catalysis of the reaction: isonocardicin A = nocardicin A. EC:5.1.1.14|KEGG_REACTION:R03073|MetaCyc:NOCARDICIN-A-EPIMERASE-RXN|RHEA:22792 go.json isonocardicin A epimerase activity http://purl.obolibrary.org/obo/GO_0050143 GO:0050144 biolink:MolecularActivity nucleoside deoxyribosyltransferase activity Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1. EC:2.4.2.6|MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN go.json deoxyribose transferase activity|nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)|nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]|nucleoside trans-N-deoxyribosylase activity|nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity|purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity|trans-N-deoxyribosylase activity|trans-N-glycosidase activity|trans-deoxyribosylase activity http://purl.obolibrary.org/obo/GO_0050144 GO:0050141 biolink:MolecularActivity nitroethane oxidase activity Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2. EC:1.7.3.1|MetaCyc:NITROETHANE-OXIDASE-RXN go.json nitroethane reductase activity|nitroethane:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050141 GO:0050142 biolink:MolecularActivity nitrogenase (flavodoxin) activity Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate. EC:1.19.6.1|MetaCyc:NITROGENASE-FLAVODOXIN-RXN|RHEA:15645 go.json reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing) http://purl.obolibrary.org/obo/GO_0050142 GO:0050158 biolink:MolecularActivity dihydroorotate dehydrogenase (NADPH) activity Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate. EC:1.3.1.15|KEGG_REACTION:R01866|MetaCyc:OROTATE-REDUCTASE-NADPH-RXN|RHEA:14861 go.json (S)-dihydroorotate:NADP+ oxidoreductase activity|L-5,6-dihydro-orotate:NAD oxidoreductase activity|dihydro-orotic dehydrogenase activity|orotate reductase (NADPH) activity|orotate reductase activity http://purl.obolibrary.org/obo/GO_0050158 GO:0050159 biolink:MolecularActivity orsellinate decarboxylase activity Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol. EC:4.1.1.58|KEGG_REACTION:R02831|MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN|RHEA:16733 go.json orsellinate carboxy-lyase (orcinol-forming)|orsellinate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0050159 GO:0050156 biolink:MolecularActivity ornithine N-benzoyltransferase activity Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+. EC:2.3.1.127|KEGG_REACTION:R00664|MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN|RHEA:16929 go.json benzoyl-CoA:L-ornithine N-benzoyltransferase activity|ornithine N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0050156 GO:0050157 biolink:MolecularActivity ornithine racemase activity Catalysis of the reaction: L-ornithine = D-ornithine. EC:5.1.1.12|MetaCyc:ORNITHINE-RACEMASE-RXN|RHEA:11584 go.json http://purl.obolibrary.org/obo/GO_0050157 GO:0015829 biolink:BiologicalProcess valine transport The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-valine transport http://purl.obolibrary.org/obo/GO_0015829 GO:0015825 biolink:BiologicalProcess L-serine transport The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-serine import http://purl.obolibrary.org/obo/GO_0015825 GO:0015826 biolink:BiologicalProcess threonine transport The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-threonine transport http://purl.obolibrary.org/obo/GO_0015826 GO:0015827 biolink:BiologicalProcess tryptophan transport The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-tryptophan transport http://purl.obolibrary.org/obo/GO_0015827 GO:0015828 biolink:BiologicalProcess tyrosine transport The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-tyrosine transport http://purl.obolibrary.org/obo/GO_0015828 GO:0015821 biolink:BiologicalProcess methionine transport The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-methionine transport http://purl.obolibrary.org/obo/GO_0015821 GO:0015822 biolink:BiologicalProcess ornithine transport The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-ornithine transport http://purl.obolibrary.org/obo/GO_0015822 GO:0015823 biolink:BiologicalProcess phenylalanine transport The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-phenylalanine transport http://purl.obolibrary.org/obo/GO_0015823 GO:0015824 biolink:BiologicalProcess proline transport The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-proline transport http://purl.obolibrary.org/obo/GO_0015824 GO:0015820 biolink:BiologicalProcess leucine transport The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-leucine transport http://purl.obolibrary.org/obo/GO_0015820 GO:0050150 biolink:MolecularActivity o-pyrocatechuate decarboxylase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = catechol + CO2. EC:4.1.1.46|KEGG_REACTION:R00821|MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN|RHEA:21492|UM-BBD_reactionID:r0579 go.json 2,3-DHBA decarboxylase activity|2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)|2,3-dihydroxybenzoate carboxy-lyase activity|2,3-dihydroxybenzoate decarboxylase activity|2,3-dihydroxybenzoic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0050150 GO:0050151 biolink:MolecularActivity oleate hydratase activity Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate. EC:4.2.1.53|KEGG_REACTION:R02813|MetaCyc:OLEATE-HYDRATASE-RXN|RHEA:21852 go.json (R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)|(R)-10-hydroxystearate 10-hydro-lyase activity http://purl.obolibrary.org/obo/GO_0050151 GO:0050154 biolink:MolecularActivity opheline kinase activity Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+. EC:2.7.3.7|KEGG_REACTION:R04388|MetaCyc:OPHELINE-KINASE-RXN|RHEA:17553 go.json ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050154 GO:0050155 biolink:MolecularActivity obsolete ornithine(lysine) transaminase activity OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate. go.json L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity|L-ornithine:2-oxoglutarate-aminotransferase activity|lysine/ornithine:2-oxoglutarate aminotransferase activity|ornithine(lysine) aminotransferase activity True http://purl.obolibrary.org/obo/GO_0050155 GO:0050152 biolink:MolecularActivity omega-amidase activity Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. EC:3.5.1.3|MetaCyc:OMEGA-AMIDASE-RXN|RHEA:11716 go.json alpha-keto acid-omega-amidase activity|omega-amidodicarboxylate amidohydrolase activity|w-amidase activity http://purl.obolibrary.org/obo/GO_0050152 GO:0050153 biolink:MolecularActivity omega-hydroxydecanoate dehydrogenase activity Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH. EC:1.1.1.66|KEGG_REACTION:R03886|MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN|RHEA:20880 go.json 10-hydroxydecanoate:NAD+ 10-oxidoreductase activity|w-hydroxydecanoate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050153 GO:0050169 biolink:MolecularActivity obsolete peptide-tryptophan 2,3-dioxygenase activity OBSOLETE. Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine. EC:1.13.11.26|MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN go.json peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)|peptidyltryptophan 2,3-dioxygenase activity|pyrrolooxygenase activity|tryptophan pyrrolooxygenase activity True http://purl.obolibrary.org/obo/GO_0050169 GO:0050167 biolink:MolecularActivity pantothenoylcysteine decarboxylase activity Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2. EC:4.1.1.30|KEGG_REACTION:R02972|MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN|RHEA:15077 go.json N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity|N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)|N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity|pantothenylcysteine decarboxylase activity http://purl.obolibrary.org/obo/GO_0050167 GO:0050168 biolink:MolecularActivity pentanamidase activity Catalysis of the reaction: H2O + pentanamide = NH4 + valerate. EC:3.5.1.50|KEGG_REACTION:R02938|MetaCyc:PENTANAMIDASE-RXN|RHEA:10000 go.json pentanamide amidohydrolase activity|valeramidase activity http://purl.obolibrary.org/obo/GO_0050168 GO:0050161 biolink:MolecularActivity succinyl-CoA:oxalate CoA-transferase Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate. EC:2.8.3.2|KEGG_REACTION:R01559|MetaCyc:OXALATE-COA-TRANSFERASE-RXN|RHEA:23588 go.json oxalate CoA-transferase activity|oxalate coenzyme A-transferase activity|succinyl-CoA:oxalate CoA-transferase activity|succinyl-beta-ketoacyl-CoA transferase activity http://purl.obolibrary.org/obo/GO_0050161 GO:0050162 biolink:MolecularActivity oxalate oxidase activity Catalysis of the reaction: 2 H+ + O2 + oxalate = 2 CO2 + H2O2. EC:1.2.3.4|KEGG_REACTION:R00273|MetaCyc:OXALATE-OXIDASE-RXN|RHEA:21880 go.json aero-oxalo dehydrogenase activity|oxalate:oxygen oxidoreductase activity|oxalic acid oxidase activity http://purl.obolibrary.org/obo/GO_0050162 GO:0050160 biolink:MolecularActivity orsellinate-depside hydrolase activity Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+. EC:3.1.1.40|KEGG_REACTION:R00054|MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN|RHEA:19549 go.json lecanorate hydrolase activity http://purl.obolibrary.org/obo/GO_0050160 GO:0050165 biolink:MolecularActivity pantetheine kinase activity Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate. EC:2.7.1.34|MetaCyc:PANTETHEINE-KINASE-RXN|RHEA:22472 go.json ATP:pantetheine 4'-phosphotransferase activity|pantetheine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050165 GO:0050166 biolink:MolecularActivity pantoate 4-dehydrogenase activity Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH. EC:1.1.1.106|KEGG_REACTION:R02471|MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN|RHEA:23000 go.json (R)-pantoate:NAD+ 4-oxidoreductase activity|D-pantoate:NAD+ 4-oxidoreductase activity|panthothenase activity|pantoate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050166 GO:0050163 biolink:MolecularActivity oxaloacetate tautomerase activity Catalysis of the reaction: oxaloacetate = enol-oxaloacetate. EC:5.3.2.2|KEGG_REACTION:R00363|MetaCyc:OXALOACETATE-TAUTOMERASE-RXN|RHEA:16021 go.json oxalacetic keto-enol isomerase activity|oxaloacetate keto-enol tautomerase activity|oxaloacetate keto-enol-isomerase activity http://purl.obolibrary.org/obo/GO_0050163 GO:0050164 biolink:MolecularActivity oxoglutarate dehydrogenase (NADP+) activity Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = CO2 + NADPH + succinyl-CoA. EC:1.2.1.52|KEGG_REACTION:R00265|MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN|RHEA:21400 go.json 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating) http://purl.obolibrary.org/obo/GO_0050164 GO:0050178 biolink:MolecularActivity phenylpyruvate tautomerase activity Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. EC:5.3.2.1|MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN|RHEA:17097 go.json phenylpyruvate keto--enol tautomerase activity|phenylpyruvate keto-enol-isomerase activity|phenylpyruvic keto--enol isomerase activity http://purl.obolibrary.org/obo/GO_0050178 GO:0050179 biolink:MolecularActivity phenylserine aldolase activity Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine. EC:4.1.2.26|KEGG_REACTION:R01766|MetaCyc:PHENYLSERINE-ALDOLASE-RXN|RHEA:21712 go.json L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)|L-threo-3-phenylserine benzaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0050179 GO:0015807 biolink:BiologicalProcess L-amino acid transport The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015807 GO:0015808 biolink:BiologicalProcess L-alanine transport The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015808 GO:0015809 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015809 GO:0015803 biolink:BiologicalProcess branched-chain amino acid transport The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. go.json branched-chain aliphatic amino acid transport|branched-chain amino-acid anion transport|branched-chain amino-acid anions transport http://purl.obolibrary.org/obo/GO_0015803 GO:0015804 biolink:BiologicalProcess neutral amino acid transport The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015804 GO:0015805 biolink:BiologicalProcess S-adenosyl-L-methionine transport The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json S-adenosyl methionine transport|S-adenosylmethionine transport|SAM transport http://purl.obolibrary.org/obo/GO_0015805 GO:0015806 biolink:BiologicalProcess S-methylmethionine transport The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015806 GO:0015800 biolink:BiologicalProcess acidic amino acid transport The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015800 GO:0015801 biolink:BiologicalProcess aromatic amino acid transport The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015801 GO:0015802 biolink:BiologicalProcess basic amino acid transport The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015802 GO:0050172 biolink:MolecularActivity phenylalanine 2-monooxygenase activity Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O. EC:1.13.12.9|KEGG_REACTION:R00690|MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN|RHEA:10712 go.json L-phenylalanine oxidase (deaminating and decarboxylating)|L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)|l-phenylalanine oxidase (deaminating and decarboxylating) activity|phenylalanine (deaminating, decarboxylating) oxidase activity|phenylalanine (deaminating, decarboxylating)oxidase activity http://purl.obolibrary.org/obo/GO_0050172 GO:0050173 biolink:MolecularActivity obsolete phenylalanine adenylyltransferase activity OBSOLETE. Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H+. EC:2.7.7.54|KEGG_REACTION:R00687|MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN go.json ATP:L-phenylalanine adenylyltransferase activity|ATP:phenylalanine adenylyltransferase activity|L-phenylalanine adenylyltransferase activity True http://purl.obolibrary.org/obo/GO_0050173 GO:0050170 biolink:MolecularActivity peptidyl-glutaminase activity Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3. EC:3.5.1.43|MetaCyc:PEPTIDYL-GLUTAMINASE-RXN|RHEA:10032 go.json peptideglutaminase activity|peptidoglutaminase I activity|peptidoglutaminase activity|peptidyl-L-glutamine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050170 GO:0050171 biolink:MolecularActivity phenol beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside. EC:2.4.1.35|MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN go.json UDP glucosyltransferase activity|UDP-glucose glucosyltransferase activity|UDP-glucose:phenol beta-D-glucosyltransferase activity|UDPglucose:phenol beta-D-glucosyltransferase activity|UDPglucosyltransferase activity|phenol b-glucosyltransferase activity|phenol-beta-D-glucosyltransferase activity|uridine diphosphoglucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050171 GO:0050176 biolink:MolecularActivity phenylalanine N-acetyltransferase activity Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+. EC:2.3.1.53|KEGG_REACTION:R00693|MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN|RHEA:17801 go.json acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity|acetyl-CoA:L-phenylalanine N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0050176 GO:0050177 biolink:MolecularActivity phenylpyruvate decarboxylase activity Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2. EC:4.1.1.43|MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN|RHEA:14185 go.json phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)|phenylpyruvate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0050177 GO:0050174 biolink:MolecularActivity phenylalanine decarboxylase activity Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2. EC:4.1.1.53|MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN|RHEA:19717 go.json L-phenylalanine carboxy-lyase (phenylethylamine-forming)|L-phenylalanine carboxy-lyase activity|L-phenylalanine decarboxylase activity|aromatic L-amino acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0050174 GO:0050175 biolink:MolecularActivity phenylalanine dehydrogenase activity Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH. EC:1.4.1.20|MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN|RHEA:21408 go.json L-phenylalanine dehydrogenase activity|L-phenylalanine:NAD+ oxidoreductase (deaminating)|PHD|PheDH activity http://purl.obolibrary.org/obo/GO_0050175 GO:0050189 biolink:MolecularActivity phosphoenolpyruvate phosphatase activity Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate. EC:3.1.3.60|KEGG_REACTION:R00208|MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN|RHEA:19997 go.json PEP phosphatase activity|phosphoenolpyruvate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0050189 GO:0050180 biolink:MolecularActivity phloretin hydrolase activity Catalysis of the reaction: H2O + phloretin = H+ + phloretate + phloroglucinol. EC:3.7.1.4|KEGG_REACTION:R02901|MetaCyc:PHLORETIN-HYDROLASE-RXN|RHEA:23396 go.json 2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity|lactase-phlorizin hydrolase http://purl.obolibrary.org/obo/GO_0050180 GO:0050183 biolink:MolecularActivity phosphatidylcholine 12-monooxygenase activity Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H+ + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD+. EC:1.14.18.4|KEGG_REACTION:R03476|MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN|RHEA:46360 go.json 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)|oleate D12-hydroxylase activity|oleate Delta(12)-hydroxylase activity|oleate delta12-hydroxylase activity|oleate delta12-monooxygenase activity|ricinoleic acid synthase activity http://purl.obolibrary.org/obo/GO_0050183 GO:0050184 biolink:MolecularActivity phosphatidylcholine desaturase activity Catalysis of the reaction: An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O. EC:1.14.19.22|KEGG_REACTION:R03475|MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN|RHEA:46332 go.json 1-16:0-2-18:1-phosphatidylcholine desaturase activity|1-18:1-2-18:2-phosphatidylcholine desaturase activity|1-18:1-2-18:2-phosphatidylcholine synthase activity|1-18:1-2-18:3-phosphatidylcholinedesaturase activity|1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming)|1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity|acyl-lipid omega-6 desaturase (cytochrome b5)|linoleate synthase activity|oleate desaturase activity|oleoyl-CoA desaturase activity|oleoylphosphatidylcholine desaturase activity http://purl.obolibrary.org/obo/GO_0050184 GO:0050181 biolink:MolecularActivity phorbol-diester hydrolase activity Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate. EC:3.1.1.51|KEGG_REACTION:R04119|MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN|RHEA:21316 go.json 12,13-diacylphorbate 12-acylhydrolase activity|PDEH|diacylphorbate 12-hydrolase activity|phorbol-12,13-diester 12-ester hydrolase activity http://purl.obolibrary.org/obo/GO_0050181 GO:0050182 biolink:MolecularActivity phosphate butyryltransferase activity Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA. EC:2.3.1.19|KEGG_REACTION:R01174|MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN|RHEA:20892 go.json butanoyl-CoA:phosphate butanoyltransferase activity|phosphotransbutyrylase activity http://purl.obolibrary.org/obo/GO_0050182 GO:0050187 biolink:MolecularActivity phosphoamidase activity Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate. EC:3.9.1.1|KEGG_REACTION:R01882|MetaCyc:PHOSPHOAMIDASE-RXN|RHEA:12977 go.json creatine phosphatase activity|phosphamide hydrolase activity http://purl.obolibrary.org/obo/GO_0050187 GO:0050188 biolink:MolecularActivity phosphoenolpyruvate mutase activity Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate. EC:5.4.2.9|KEGG_REACTION:R00661|MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN|RHEA:17013 go.json PEP mutase activity|PEP phosphomutase activity|PEPPM|phosphoenolpyruvate 2,3-phosphonomutase activity|phosphoenolpyruvate phosphomutase activity|phosphoenolpyruvate-phosphonopyruvate phosphomutase activity http://purl.obolibrary.org/obo/GO_0050188 GO:0050185 biolink:MolecularActivity phosphatidylinositol deacylase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+. EC:3.1.1.52|KEGG_REACTION:R03360|MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN|RHEA:18001 go.json 1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity|phosphatidylinositol phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0050185 GO:0050186 biolink:MolecularActivity phosphoadenylylsulfatase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate. EC:3.6.2.2|MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN|RHEA:11232 go.json 3'-phosphoadenylylsulfate sulfohydrolase activity|3-phosphoadenosine 5-phosphosulfate sulfatase activity|3-phosphoadenylyl sulfatase activity|PAPS sulfatase activity|phosphoadenylylsulphatase activity http://purl.obolibrary.org/obo/GO_0050186 GO:0050190 biolink:MolecularActivity phosphoglucokinase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+. EC:2.7.1.10|KEGG_REACTION:R00949|MetaCyc:PHOSPHOGLUCOKINASE-RXN|RHEA:13377 go.json ATP:D-glucose-1-phosphate 6-phosphotransferase activity|ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity|glucose-phosphate kinase activity|phosphoglucokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050190 GO:0050191 biolink:MolecularActivity phosphoglycerate kinase (GTP) activity Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H+. EC:2.7.2.10|KEGG_REACTION:R01517|MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN|RHEA:23332 go.json GTP:3-phospho-D-glycerate 1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0050191 GO:0050194 biolink:MolecularActivity phosphonoacetaldehyde hydrolase activity Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate. EC:3.11.1.1|KEGG_REACTION:R00747|MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN|RHEA:18905 go.json 2-oxoethylphosphonate phosphonohydrolase activity|2-phosphonoacetylaldehyde phosphonohydrolase activity|phosphonatase activity|phosphonoacetylaldehyde phosphonohydrolase activity http://purl.obolibrary.org/obo/GO_0050194 GO:0050195 biolink:MolecularActivity phosphoribokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+. EC:2.7.1.18|KEGG_REACTION:R01050|MetaCyc:PHOSPHORIBOKINASE-RXN|RHEA:21216 go.json ATP:D-ribose-5-phosphate 1-phosphotransferase activity|phosphoribokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0050195 GO:0050192 biolink:MolecularActivity phosphoglycerate phosphatase activity Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate. EC:3.1.3.20|KEGG_REACTION:R01748|MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN|RHEA:21156 go.json D-2-phosphoglycerate phosphatase activity|D-glycerate-2-phosphate phosphohydrolase activity|glycerophosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0050192 GO:0050193 biolink:MolecularActivity phosphoketolase activity Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. EC:4.1.2.9|MetaCyc:PHOSPHOKETOLASE-RXN|RHEA:10468 go.json D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)|D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity|xylulose-5-phosphate phosphoketolase activity http://purl.obolibrary.org/obo/GO_0050193 GO:0050198 biolink:MolecularActivity pinosylvin synthase activity Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin. EC:2.3.1.146|KEGG_REACTION:R02505|MetaCyc:PINOSYLVIN-SYNTHASE-RXN|RHEA:12552 go.json malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)|pine stilbene synthase activity|stilbene synthase activity http://purl.obolibrary.org/obo/GO_0050198 GO:0050199 biolink:MolecularActivity piperidine N-piperoyltransferase activity Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+. EC:2.3.1.145|KEGG_REACTION:R03994|MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN|RHEA:14561 go.json (E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity|piperidine piperoyltransferase activity|piperoyl-CoA:piperidine N-piperoyltransferase activity http://purl.obolibrary.org/obo/GO_0050199 GO:0050196 biolink:MolecularActivity [phosphorylase] phosphatase activity Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate. EC:3.1.3.17|MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN go.json PR-enzyme|glycogen phosphorylase phosphatase activity|phosphorylase a phosphatase activity|phosphorylase a phosphohydrolase activity|phosphorylase phosphatase activity|protein phosphatase C|type 1 protein phosphatase activity http://purl.obolibrary.org/obo/GO_0050196 GO:0050197 biolink:MolecularActivity phytanate-CoA ligase activity Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA. EC:6.2.1.24|KEGG_REACTION:R03631|MetaCyc:PHYTANATE--COA-LIGASE-RXN|RHEA:21380|Reactome:R-HSA-389622 go.json phytanate:CoA ligase (AMP-forming)|phytanoyl-CoA ligase activity http://purl.obolibrary.org/obo/GO_0050197 GO:0001136 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001136 GO:0001137 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001137 GO:0001138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001138 GO:0001139 biolink:MolecularActivity RNA polymerase II complex recruiting activity Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. go.json core RNA polymerase II recruiting transcription factor activity|transcription factor activity, core RNA polymerase II recruiting http://purl.obolibrary.org/obo/GO_0001139 GO:0001132 biolink:MolecularActivity obsolete RNA polymerase II transcription factor activity, TBP-class protein binding OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well. go.json TATA-binding protein binding RNA polymerase II transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity|TRF protein binding RNA polymerase II transcription factor activity True http://purl.obolibrary.org/obo/GO_0001132 GO:0001133 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001133 GO:0001134 biolink:MolecularActivity obsolete transcription regulator recruiting activity OBSOLETE. The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation. go.json transcription factor activity, transcription factor recruiting|transcription factor recruiting activity|transcription factor recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001134 GO:0001135 biolink:MolecularActivity obsolete RNA polymerase II transcription regulator recruiting activity OBSOLETE. The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation. go.json RNA polymerase II transcription factor recruiting activity|RNA polymerase II transcription factor recruiting transcription factor activity|TFIIE-class transcription factor recruiting transcription factor activity|TFIIF-class transcription factor recruiting transcription factor activity|TFIIH-class transcription factor recruiting transcription factor activity|transcription factor activity, RNA polymerase II transcription factor recruiting|transcription factor activity, TFIIE-class transcription factor recruiting|transcription factor activity, TFIIF-class transcription factor recruiting|transcription factor activity, TFIIH-class transcription factor recruiting True http://purl.obolibrary.org/obo/GO_0001135 GO:0001130 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001130 GO:0001131 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001131 GO:0015777 biolink:BiologicalProcess teichoic acid transport The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. go.json http://purl.obolibrary.org/obo/GO_0015777 GO:0015778 biolink:BiologicalProcess hexuronide transmembrane transport The directed movement of hexuronide across a membrane. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate. go.json hexuronide transport http://purl.obolibrary.org/obo/GO_0015778 GO:0015779 biolink:BiologicalProcess glucuronoside transport The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. go.json glucuronide transport http://purl.obolibrary.org/obo/GO_0015779 GO:0015773 biolink:BiologicalProcess raffinose transport The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. go.json http://purl.obolibrary.org/obo/GO_0015773 GO:0015774 biolink:BiologicalProcess polysaccharide transport The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json http://purl.obolibrary.org/obo/GO_0015774 GO:0015775 biolink:BiologicalProcess beta-glucan transport The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. go.json http://purl.obolibrary.org/obo/GO_0015775 GO:0015776 biolink:BiologicalProcess capsular polysaccharide transport The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. go.json capsular-polysaccharide transport|capsule polysaccharide transport http://purl.obolibrary.org/obo/GO_0015776 GO:0015770 biolink:BiologicalProcess sucrose transport The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside. go.json http://purl.obolibrary.org/obo/GO_0015770 GO:0015771 biolink:BiologicalProcess trehalose transport The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. go.json http://purl.obolibrary.org/obo/GO_0015771 GO:0015772 biolink:BiologicalProcess oligosaccharide transport The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. go.json http://purl.obolibrary.org/obo/GO_0015772 GO:0001147 biolink:MolecularActivity transcription termination site sequence-specific DNA binding Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon. go.json bacterial-type RNA polymerase termination site sequence-specific DNA binding|mitochondrial RNA polymerase termination site sequence-specific DNA binding|mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity|transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding|transcription termination site DNA binding http://purl.obolibrary.org/obo/GO_0001147 GO:0001148 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001148 GO:0001149 biolink:MolecularActivity obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding OBSOLETE. Binding to a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase. go.json bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001149 GO:0001143 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001143 GO:0001144 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001144 GO:0001145 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001145 GO:0001146 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001146 GO:0001140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001140 GO:0001141 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001141 GO:0001142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001142 GO:0015788 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015788 GO:0015789 biolink:BiologicalProcess UDP-N-acetylgalactosamine transmembrane transport The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. go.json UDP-N-acetylgalactosamine transport http://purl.obolibrary.org/obo/GO_0015789 GO:0015784 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015784 GO:0015785 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015785 GO:0015786 biolink:BiologicalProcess UDP-glucose transmembrane transport The process in which UDP-glucose is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_0015786 GO:0015787 biolink:BiologicalProcess UDP-glucuronic acid transmembrane transport The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. go.json UDP-glucuronic acid transport http://purl.obolibrary.org/obo/GO_0015787 GO:0015780 biolink:BiologicalProcess nucleotide-sugar transmembrane transport The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json nucleotide-sugar transport http://purl.obolibrary.org/obo/GO_0015780 GO:0015781 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015781 GO:0015782 biolink:BiologicalProcess CMP-N-acetylneuraminate transmembrane transport The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json CMP-N-acetylneuraminate transport|CMP-sialic acid transport http://purl.obolibrary.org/obo/GO_0015782 GO:0015783 biolink:BiologicalProcess GDP-fucose transmembrane transport The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. go.json GDP-fucose transport http://purl.obolibrary.org/obo/GO_0015783 GO:0001114 biolink:CellularComponent protein-DNA-RNA complex A macromolecular complex containing protein, DNA, and RNA molecules. go.json http://purl.obolibrary.org/obo/GO_0001114 GO:0001115 biolink:BiologicalProcess protein-DNA-RNA complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex. go.json protein-DNA-RNA complex subunit organisation http://purl.obolibrary.org/obo/GO_0001115 GO:0001116 biolink:BiologicalProcess protein-DNA-RNA complex assembly The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex. go.json http://purl.obolibrary.org/obo/GO_0001116 GO:0001117 biolink:BiologicalProcess protein-DNA-RNA complex disassembly The disaggregation of a protein-DNA-RNA complex into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0001117 GO:0001110 biolink:BiologicalProcess RNA polymerase III promoter clearance A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase. go.json promoter clearance from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0001110 GO:0001111 biolink:BiologicalProcess RNA polymerase II promoter clearance A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. go.json promoter clearance from RNA polymerase II promoter|promoter escape from RNA polymerase II promoter|promoter-paused RNA polymerase II release http://purl.obolibrary.org/obo/GO_0001111 GO:0001112 biolink:BiologicalProcess DNA-templated transcription open complex formation Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. go.json DNA-dependent transcriptional open complex formation|DNA-templated transcriptional open complex formation|promoter melting|transcription open complex formation at bacterial-type RNA polymerase promoter|transcriptional open complex formation at bacterial-type RNA polymerase promoter http://purl.obolibrary.org/obo/GO_0001112 GO:0001113 biolink:BiologicalProcess transcription open complex formation at RNA polymerase II promoter Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. go.json RNA polymerase II promoter melting|transcriptional open complex formation at RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0001113 GO:0015759 biolink:BiologicalProcess beta-glucoside transport The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. go.json http://purl.obolibrary.org/obo/GO_0015759 GO:0039722 biolink:BiologicalProcess suppression by virus of host toll-like receptor signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism. go.json inhibition of host TLR pathway by virus|suppression by virus of host TLR signaling pathway http://purl.obolibrary.org/obo/GO_0039722 GO:0015755 biolink:BiologicalProcess fructose transmembrane transport The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. go.json fructose transport http://purl.obolibrary.org/obo/GO_0015755 GO:0015756 biolink:BiologicalProcess fucose transmembrane transport The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. go.json fucose transport http://purl.obolibrary.org/obo/GO_0015756 GO:0039723 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1. go.json inhibition of host TBK1 by virus|suppression by virus of host TBK1 activity http://purl.obolibrary.org/obo/GO_0039723 GO:0015757 biolink:BiologicalProcess galactose transmembrane transport The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. go.json galactose transport http://purl.obolibrary.org/obo/GO_0015757 GO:0039720 biolink:CellularComponent virogenic stroma A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled. go.json VS http://purl.obolibrary.org/obo/GO_0039720 GO:0039721 biolink:CellularComponent peristromal region viral factory A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses. go.json PR http://purl.obolibrary.org/obo/GO_0039721 GO:0015758 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015758 GO:0015751 biolink:BiologicalProcess arabinose transmembrane transport The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other. go.json arabinose transport http://purl.obolibrary.org/obo/GO_0015751 GO:0015752 biolink:BiologicalProcess D-ribose transmembrane transport The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. go.json D-ribose transport http://purl.obolibrary.org/obo/GO_0015752 GO:0015753 biolink:BiologicalProcess D-xylose transmembrane transport The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. go.json D-xylose transport http://purl.obolibrary.org/obo/GO_0015753 GO:0039724 biolink:BiologicalProcess suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E). go.json inhibition of host IKBKE by virus|suppression by virus of host IKBKE activity http://purl.obolibrary.org/obo/GO_0039724 GO:0015754 biolink:BiologicalProcess allose transmembrane transport The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. go.json allose transport http://purl.obolibrary.org/obo/GO_0015754 GO:0015750 biolink:BiologicalProcess pentose transmembrane transport The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule. go.json pentose transport http://purl.obolibrary.org/obo/GO_0015750 GO:0001118 biolink:BiologicalProcess transcription ternary complex disassembly The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components. go.json transcription protein-DNA-RNA complex disassembly http://purl.obolibrary.org/obo/GO_0001118 GO:0001119 biolink:BiologicalProcess protein-DNA-RNA complex remodeling The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex. go.json http://purl.obolibrary.org/obo/GO_0001119 GO:0001125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001125 GO:0001126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001126 GO:0001127 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001127 GO:0001128 biolink:MolecularActivity obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly OBSOLETE. Binding to an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. go.json RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly True http://purl.obolibrary.org/obo/GO_0001128 GO:0001121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001121 GO:0001122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001122 GO:0001123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001123 GO:0001124 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001124 GO:0039719 biolink:CellularComponent tube viral factory A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories. go.json http://purl.obolibrary.org/obo/GO_0039719 GO:0039717 biolink:CellularComponent spherule viral factory A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus. Wikipedia:Viroplasm go.json http://purl.obolibrary.org/obo/GO_0039717 GO:0001120 biolink:BiologicalProcess protein-DNA complex remodeling The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex. go.json protein-DNA complex remodelling http://purl.obolibrary.org/obo/GO_0001120 GO:0039718 biolink:CellularComponent double membrane vesicle viral factory A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae. go.json DMV viral factory http://purl.obolibrary.org/obo/GO_0039718 GO:0015766 biolink:BiologicalProcess disaccharide transport The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units. go.json http://purl.obolibrary.org/obo/GO_0015766 GO:0039711 biolink:BiologicalProcess cytoplasmic helical capsid assembly The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome. go.json http://purl.obolibrary.org/obo/GO_0039711 GO:0015767 biolink:BiologicalProcess lactose transport The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. go.json http://purl.obolibrary.org/obo/GO_0015767 GO:0039712 biolink:BiologicalProcess obsolete induction by virus of host catalytic activity OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host catalytic activity. go.json induction by virus of host enzyme activity True http://purl.obolibrary.org/obo/GO_0039712 GO:0015768 biolink:BiologicalProcess maltose transport The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch. go.json http://purl.obolibrary.org/obo/GO_0015768 GO:0015769 biolink:BiologicalProcess melibiose transport The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. go.json http://purl.obolibrary.org/obo/GO_0015769 GO:0039710 biolink:BiologicalProcess cytoplasmic icosahedral capsid assembly The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome. go.json http://purl.obolibrary.org/obo/GO_0039710 GO:0015762 biolink:BiologicalProcess rhamnose transmembrane transport The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. go.json rhamnose transport http://purl.obolibrary.org/obo/GO_0015762 GO:0039715 biolink:CellularComponent nuclear viral factory A viral factory located in the nucleus of a host cell. go.json http://purl.obolibrary.org/obo/GO_0039715 GO:0039716 biolink:CellularComponent viroplasm viral factory A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae. Wikipedia:Viroplasm go.json http://purl.obolibrary.org/obo/GO_0039716 GO:0015763 biolink:BiologicalProcess N-acetylgalactosamine transport The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. go.json http://purl.obolibrary.org/obo/GO_0015763 GO:0039713 biolink:CellularComponent viral factory An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments. VZ:1951 go.json virus factory http://purl.obolibrary.org/obo/GO_0039713 GO:0015764 biolink:BiologicalProcess N-acetylglucosamine transport The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015764 GO:0015765 biolink:BiologicalProcess methylgalactoside transport The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. go.json http://purl.obolibrary.org/obo/GO_0015765 GO:0039714 biolink:CellularComponent cytoplasmic viral factory A viral factory located in the cytoplasm of a host cell. go.json http://purl.obolibrary.org/obo/GO_0039714 GO:0015760 biolink:BiologicalProcess glucose-6-phosphate transport The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. go.json http://purl.obolibrary.org/obo/GO_0015760 GO:0015761 biolink:BiologicalProcess mannose transmembrane transport The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. go.json mannose transport http://purl.obolibrary.org/obo/GO_0015761 GO:0001129 biolink:MolecularActivity obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. go.json TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly True http://purl.obolibrary.org/obo/GO_0001129 GO:0050103 biolink:MolecularActivity dextrin dextranase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1). EC:2.4.1.2|MetaCyc:DEXTRIN-DEXTRANASE-RXN|RHEA:14625 go.json 1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity|dextran dextrinase activity|dextrin 6-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050103 GO:1990277 biolink:BiologicalProcess parasexual reproduction with cellular fusion A type of reproduction in which new individuals are produced from two individuals, with the fusion of two somatic cells. Wikipedia:Parasexual_cycle go.json mating|parasexual conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_1990277 GO:0050104 biolink:MolecularActivity L-gulonate 3-dehydrogenase activity Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH. EC:1.1.1.45|KEGG_REACTION:R02640|MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN|RHEA:12889|Reactome:R-HSA-5661290 go.json L-3-aldonate dehydrogenase activity|L-3-aldonic dehydrogenase activity|L-3-hydroxyacid dehydrogenase activity|L-beta-hydroxy-acid-NAD-oxidoreductase activity|L-beta-hydroxyacid dehydrogenase activity|L-gulonate:NAD+ 3-oxidoreductase activity|L-gulonic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050104 GO:1990278 biolink:BiologicalProcess obsolete positive regulation of MBF transcription factor activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor MBF. go.json positive regulation of MBF transcription factor activity True http://purl.obolibrary.org/obo/GO_1990278 GO:1990279 biolink:BiologicalProcess obsolete negative regulation of MBF transcription factor activity OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor MBF. go.json negative regulation of MBF transcription factor activity True http://purl.obolibrary.org/obo/GO_1990279 GO:0050101 biolink:MolecularActivity mimosinase activity Catalysis of the reaction: L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine. EC:4.3.3.8|KEGG_REACTION:R04350|MetaCyc:MIMOSINASE-RXN|RHEA:75355 go.json mimosine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050101 GO:0050102 biolink:MolecularActivity cellodextrin phosphorylase activity Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. EC:2.4.1.49|MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN|RHEA:23024 go.json 1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity|beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050102 GO:0050107 biolink:MolecularActivity monoterpenol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester. EC:2.3.1.69|MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN go.json acetyl-CoA:monoterpenol O-acetyltransferase activity|menthol transacetylase activity http://purl.obolibrary.org/obo/GO_0050107 GO:1990273 biolink:BiologicalProcess snRNA capping The addition of a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA). Capping 7SK RNA stabilizes it. go.json snRNA 5'-end processing http://purl.obolibrary.org/obo/GO_1990273 GO:1990274 biolink:BiologicalProcess mitotic actomyosin contractile ring disassembly Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle. go.json mitotic CAR disassembly|mitotic actomyosin ring disassembly|mitotic constriction ring disassembly|mitotic contractile actomyosin ring disassembly|mitotic cytokinetic ring disassembly http://purl.obolibrary.org/obo/GO_1990274 GO:0050108 biolink:MolecularActivity monoterpenyl-diphosphatase activity Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate. EC:3.1.7.3|MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN go.json bornyl diphosphate hydrolase activity|bornyl pyrophosphate hydrolase activity|monoterpenyl-diphosphate diphosphohydrolase activity|monoterpenyl-pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0050108 GO:1990275 biolink:MolecularActivity preribosome binding Binding to a preribosome. go.json http://purl.obolibrary.org/obo/GO_1990275 GO:0050105 biolink:MolecularActivity L-gulonolactone oxidase activity Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2. EC:1.1.3.8|MetaCyc:L-GULONOLACTONE-OXIDASE-RXN|RHEA:32363 go.json GLO activity|L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity|L-gulono-gamma-lactone oxidase activity|L-gulono-gamma-lactone:O2 oxidoreductase activity|L-gulono-gamma-lactone:oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050105 GO:0050106 biolink:MolecularActivity monomethyl-sulfatase activity Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate. EC:3.1.6.16|KEGG_REACTION:R01145|MetaCyc:MONOMETHYL-SULFATASE-RXN|RHEA:14221 go.json monomethyl-sulfate sulfohydrolase activity|monomethyl-sulphatase activity http://purl.obolibrary.org/obo/GO_0050106 GO:1990276 biolink:MolecularActivity RNA 5'-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_1990276 GO:0039708 biolink:BiologicalProcess nuclear capsid assembly The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly. VZ:1516 go.json http://purl.obolibrary.org/obo/GO_0039708 GO:0039709 biolink:BiologicalProcess cytoplasmic capsid assembly The assembly of a virus capsid that occurs in the cytoplasm. VZ:1950 go.json http://purl.obolibrary.org/obo/GO_0039709 GO:1990270 biolink:CellularComponent platelet-derived growth factor receptor-ligand complex A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes. go.json PDGF complex|PDGF receptor-ligand complex|PDGF-AA-receptor alpha complex|PDGF-AB-receptor alpha complex|PDGF-AB-receptor beta complex|PDGF-BB-receptor alpha complex|PDGF-BB-receptor alpha-beta complex|PDGF-BB-receptor beta complex|PDGF-CC-receptor alpha complex|PDGF-CC-receptor alpha-beta complex|PDGF-CC-receptor beta complex|PDGF-DD-receptor alpha-beta complex|PDGF-DD-receptor beta complex|receptor-ligand complex http://purl.obolibrary.org/obo/GO_1990270 GO:0050109 biolink:MolecularActivity morphine 6-dehydrogenase activity Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+. EC:1.1.1.218|MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN go.json morphine:NAD(P)+ 6-oxidoreductase activity|naloxone reductase activity|reductase, naloxone http://purl.obolibrary.org/obo/GO_0050109 GO:0039706 biolink:MolecularActivity co-receptor binding Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. go.json http://purl.obolibrary.org/obo/GO_0039706 GO:1990271 biolink:MolecularActivity obsolete anti-Mullerian hormone OBSOLETE. Combining with anti-Mullerian hormone to initiate a change in cell activity. go.json anti-Mullerian hormone True http://purl.obolibrary.org/obo/GO_1990271 GO:0039707 biolink:BiologicalProcess virus-mediated pore formation in host cell membrane The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism. go.json pore formation by virus in membrane of host cell|pore formation in membrane of host cell by virus|viroporin http://purl.obolibrary.org/obo/GO_0039707 GO:1990272 biolink:MolecularActivity anti-Mullerian hormone receptor activity Combining with anti-Mullerian hormone to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_1990272 GO:0015737 biolink:BiologicalProcess galacturonate transmembrane transport The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other. go.json galacturonate transport http://purl.obolibrary.org/obo/GO_0015737 GO:0015738 biolink:BiologicalProcess glucuronate transmembrane transport The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other. go.json glucuronate transport http://purl.obolibrary.org/obo/GO_0015738 GO:0015739 biolink:BiologicalProcess sialic acid transport The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015739 GO:0015733 biolink:BiologicalProcess shikimate transmembrane transport The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other. go.json shikimate transport http://purl.obolibrary.org/obo/GO_0015733 GO:0039700 biolink:BiologicalProcess fusion of viral membrane with host outer nuclear membrane Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit. go.json fusion of viral membrane with host outer nuclear membrane involved in nuclear egress|viral primary envelope fusion with host outer nuclear membrane http://purl.obolibrary.org/obo/GO_0039700 GO:0039701 biolink:BiologicalProcess microtubule-dependent intracellular transport of viral material towards cell periphery The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane. VZ:1816 go.json http://purl.obolibrary.org/obo/GO_0039701 GO:0015734 biolink:BiologicalProcess taurine transport The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015734 GO:0015735 biolink:BiologicalProcess uronic acid transmembrane transport The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other. go.json uronic acid transport http://purl.obolibrary.org/obo/GO_0015735 GO:0015736 biolink:BiologicalProcess hexuronate transmembrane transport The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. go.json hexuronate transport http://purl.obolibrary.org/obo/GO_0015736 GO:0039704 biolink:BiologicalProcess viral translational shunt A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site. VZ:608 go.json ribosomal shunt initiation pathway http://purl.obolibrary.org/obo/GO_0039704 GO:0039705 biolink:BiologicalProcess viral translational readthrough The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. VZ:859 go.json viral RNA suppression of termination|viral stop codon readthrough http://purl.obolibrary.org/obo/GO_0039705 GO:0015730 biolink:BiologicalProcess propanoate transmembrane transport The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json propanoate transport|propionate transport http://purl.obolibrary.org/obo/GO_0015730 GO:0039702 biolink:BiologicalProcess viral budding via host ESCRT complex Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process. VZ:1536 go.json host-assisted viral budding|viral budding through the ESCRT machinery http://purl.obolibrary.org/obo/GO_0039702 GO:0015731 biolink:BiologicalProcess 3-hydroxyphenyl propanoate transport The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 3-hydroxyphenyl propionate transport http://purl.obolibrary.org/obo/GO_0015731 GO:0015732 biolink:BiologicalProcess prostaglandin transport The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015732 GO:0039703 biolink:BiologicalProcess RNA replication The cellular metabolic process in which a cell duplicates one or more molecules of RNA. go.json http://purl.obolibrary.org/obo/GO_0039703 GO:0050100 biolink:MolecularActivity methylitaconate delta-isomerase activity Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate. EC:5.3.3.6|KEGG_REACTION:R03070|MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN|RHEA:23480 go.json methylitaconate D-isomerase activity|methylitaconate delta2-delta3-isomerase activity|methylitaconate isomerase activity http://purl.obolibrary.org/obo/GO_0050100 GO:0050114 biolink:MolecularActivity myo-inosose-2 dehydratase activity Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O. EC:4.2.1.44|KEGG_REACTION:R02782|MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN|RHEA:14065 go.json 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)|2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity|inosose 2,3-dehydratase activity|ketoinositol dehydratase activity http://purl.obolibrary.org/obo/GO_0050114 GO:0001103 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001103 GO:1990288 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990288 GO:0050115 biolink:MolecularActivity myosin-light-chain-phosphatase activity Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. EC:3.1.3.53|MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN|Reactome:R-HSA-419232 go.json [Myosin light-chain]-phosphatase activity|myosin light chain kinase phosphatase activity|myosin light-chain kinase phosphatase activity|myosin-light-chain phosphatase activity|myosin-light-chain-phosphate phosphohydrolase activity|protein phosphatase 2A http://purl.obolibrary.org/obo/GO_0050115 GO:0001104 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001104 GO:1990289 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990289 GO:0001105 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001105 GO:0050112 biolink:MolecularActivity inositol 2-dehydrogenase activity Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH. EC:1.1.1.18|KEGG_REACTION:R01183|MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN|RHEA:16949 go.json inositol:NAD 2-dehydrogenase activity|myo-inositol 2-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050112 GO:0050113 biolink:MolecularActivity inositol oxygenase activity Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+. EC:1.13.99.1|KEGG_REACTION:R01184|MetaCyc:MYO-INOSITOL-OXYGENASE-RXN|RHEA:23696|Reactome:R-HSA-5678327 go.json MOO activity|meso-inositol oxygenase activity|myo-inositol oxygenase activity|myo-inositol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050113 GO:0001106 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001106 GO:0050118 biolink:MolecularActivity N-acetyldiaminopimelate deacetylase activity Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + acetate. EC:3.5.1.47|KEGG_REACTION:R02733|MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN|RHEA:20405 go.json 6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity|N-acetyl-L-diaminopimelic acid deacylase activity|N-acetyl-LL-diaminopimelate deacylase activity|N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050118 GO:1990284 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990284 GO:0001100 biolink:BiologicalProcess negative regulation of exit from mitosis Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). go.json down regulation of exit from mitosis|down-regulation of exit from mitosis|downregulation of exit from mitosis|inhibition of exit from mitosis http://purl.obolibrary.org/obo/GO_0001100 GO:0050119 biolink:MolecularActivity N-acetylglucosamine deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate. EC:3.5.1.33|KEGG_REACTION:R01200|MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN|RHEA:20593|Reactome:R-HSA-2022887 go.json N-acetyl-D-glucosamine amidohydrolase activity|N-acetyl-D-glucosaminyl N-deacetylase activity|acetylaminodeoxyglucose acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0050119 GO:1990285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990285 GO:0050116 biolink:MolecularActivity N,N-dimethylformamidase activity Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate. EC:3.5.1.56|KEGG_REACTION:R02509|MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN|RHEA:19517 go.json DMFase activity|N,N-dimethylformamide amidohydrolase activity|dimethylformamidase activity http://purl.obolibrary.org/obo/GO_0050116 GO:0001101 biolink:BiologicalProcess response to acid chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. go.json response to acid|response to acid anion|response to oxoanion http://purl.obolibrary.org/obo/GO_0001101 gocheck_do_not_manually_annotate GO:1990286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990286 GO:0050117 biolink:MolecularActivity N-acetyl-beta-alanine deacetylase activity Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate. EC:3.5.1.21|KEGG_REACTION:R00909|MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN|RHEA:23212 go.json N-acetyl-beta-alanine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050117 GO:0001102 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001102 GO:1990287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990287 GO:1990280 biolink:BiologicalProcess RNA localization to chromatin A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. go.json RNA localisation to chromatin http://purl.obolibrary.org/obo/GO_1990280 GO:1990281 biolink:CellularComponent efflux pump complex A protein complex that is capable of efflux transmembrane transporter activity. go.json efflux pump|efflux transmembrane transporter complex http://purl.obolibrary.org/obo/GO_1990281 GO:1990282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990282 GO:1990283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990283 GO:0015748 biolink:BiologicalProcess organophosphate ester transport The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. go.json http://purl.obolibrary.org/obo/GO_0015748 GO:0015749 biolink:BiologicalProcess monosaccharide transmembrane transport The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. go.json monosaccharide transport http://purl.obolibrary.org/obo/GO_0015749 GO:0015744 biolink:BiologicalProcess succinate transport The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015744 GO:0015745 biolink:BiologicalProcess tartrate transmembrane transport The process in which tartrate is transported across a lipid bilayer, from one side of a membrane to the other. go.json tartrate transport http://purl.obolibrary.org/obo/GO_0015745 GO:0015746 biolink:BiologicalProcess citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015746 GO:0015747 biolink:BiologicalProcess urate transport The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json urate transmembrane transport|uric acid transport http://purl.obolibrary.org/obo/GO_0015747 GO:0015740 biolink:BiologicalProcess C4-dicarboxylate transport The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. go.json http://purl.obolibrary.org/obo/GO_0015740 GO:0015741 biolink:BiologicalProcess fumarate transport The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015741 GO:0015742 biolink:BiologicalProcess alpha-ketoglutarate transport The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 2-oxoglutarate transport|mitochondrial alpha-ketoglutarate/malate transport http://purl.obolibrary.org/obo/GO_0015742 GO:0015743 biolink:BiologicalProcess malate transport The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json mitochondrial alpha-ketoglutarate/malate transport http://purl.obolibrary.org/obo/GO_0015743 GO:0001107 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001107 GO:0050110 biolink:MolecularActivity mucinaminylserine mucinaminidase activity Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine. EC:3.2.1.97|KEGG_REACTION:R04527|MetaCyc:3.2.1.110-RXN go.json D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity|endo-beta-N-acetyl-D-galactosaminidase activity|endo-beta-N-acetylgalactosaminidase http://purl.obolibrary.org/obo/GO_0050110 GO:0001108 biolink:MolecularActivity bacterial-type RNA polymerase holo enzyme binding Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase. go.json basal bacterial-type RNA polymerase transcription machinery binding http://purl.obolibrary.org/obo/GO_0001108 GO:0050111 biolink:MolecularActivity mycocerosate synthase activity Catalysis of the reaction: acyl-CoA + 7n H+ + n methylmalonyl-CoA + 2n NADPH = n CO2 + n CoA + n H2O + multi-methyl-branched acyl-CoA + 2n NADP+. EC:2.3.1.111|KEGG_REACTION:R05189|MetaCyc:MYCOCEROSATE-SYNTHASE-RXN|RHEA:10588 go.json acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)|mycocerosic acid synthase activity http://purl.obolibrary.org/obo/GO_0050111 GO:0001109 biolink:BiologicalProcess promoter clearance during DNA-templated transcription Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. go.json promoter clearance during DNA-dependent transcription|promoter clearance from bacterial-type RNA polymerase promoter|promoter escape http://purl.obolibrary.org/obo/GO_0001109 GO:0050125 biolink:MolecularActivity N-benzyloxycarbonylglycine hydrolase activity Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O + H+ = benzyl alcohol + CO2 + glycine. EC:3.5.1.58|KEGG_REACTION:R02551|MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN|RHEA:20900 go.json N-benzyloxycarbonylglycine urethanehydrolase activity|benzyloxycarbonylglycine hydrolase activity|nalpha-benzyloxycarbonyl amino acid urethane hydrolase I|nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity|nalpha-carbobenzoxyamino acid amidohydrolase activity http://purl.obolibrary.org/obo/GO_0050125 GO:1990299 biolink:BiologicalProcess Bub1-Bub3 complex localization to kinetochore A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. go.json http://purl.obolibrary.org/obo/GO_1990299 GO:0050126 biolink:MolecularActivity N-carbamoylputrescine amidase activity Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine. EC:3.5.1.53|KEGG_REACTION:R01152|MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN|RHEA:22284 go.json N-carbamoylputrescine amidohydrolase activity|NCP|carbamoylputrescine hydrolase activity http://purl.obolibrary.org/obo/GO_0050126 GO:0050123 biolink:MolecularActivity N-acylmannosamine 1-dehydrogenase activity Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + H+ + NADH. EC:1.1.1.233|KEGG_REACTION:R02651|MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN|RHEA:11540 go.json N-acetyl-D-mannosamine dehydrogenase activity|N-acyl-D-mannosamine dehydrogenase activity|N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity|N-acylmannosamine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050123 GO:0050124 biolink:MolecularActivity N-acylneuraminate-9-phosphatase activity Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. EC:3.1.3.29|MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN|RHEA:13057|Reactome:R-HSA-4084989 go.json N-acylneuraminate-9-phosphate phosphohydrolase activity|N-acylneuraminic (sialic) acid 9-phosphatase activity|N-acylneuraminic acid 9-phosphate phosphatase activity|acylneuraminate 9-phosphatase activity http://purl.obolibrary.org/obo/GO_0050124 GO:0050129 biolink:MolecularActivity N-formylglutamate deformylase activity Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate. EC:3.5.1.68|KEGG_REACTION:R00525|MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN|RHEA:12476 go.json N-formyl-L-glutamate amidohydrolase activity|N-formylglutamate hydrolase activity|beta-citryl-L-glutamate amidase activity|beta-citryl-L-glutamate amidohydrolase activity|beta-citryl-L-glutamate hydrolase activity|beta-citryl-L-glutamate-hydrolyzing enzyme|beta-citrylglutamate amidase activity|formylglutamate deformylase activity http://purl.obolibrary.org/obo/GO_0050129 GO:1990295 biolink:CellularComponent post-anaphase microtubule array A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center. go.json PAA|post-anaphase array http://purl.obolibrary.org/obo/GO_1990295 GO:1990296 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990296 GO:0050127 biolink:MolecularActivity N-carbamoylsarcosine amidase activity Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine. EC:3.5.1.59|KEGG_REACTION:R01563|MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN|RHEA:20057 go.json CSHase activity|N-carbamoylsarcosine amidohydrolase activity|carbamoylsarcosine amidase activity http://purl.obolibrary.org/obo/GO_0050127 GO:1990297 biolink:BiologicalProcess renal amino acid absorption A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. go.json http://purl.obolibrary.org/obo/GO_1990297 GO:0050128 biolink:MolecularActivity N-feruloylglycine deacylase activity Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine. EC:3.5.1.71|KEGG_REACTION:R03579|MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN|RHEA:10484 go.json N-feruloylglycine amidohydrolase activity|N-feruloylglycine hydrolase activity http://purl.obolibrary.org/obo/GO_0050128 GO:1990298 biolink:CellularComponent bub1-bub3 complex Protein complex that associates with the kinetochores. go.json http://purl.obolibrary.org/obo/GO_1990298 GO:0015719 biolink:BiologicalProcess allantoate transport The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json allantoin/allantoate transport http://purl.obolibrary.org/obo/GO_0015719 GO:1990291 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990291 GO:1990292 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990292 GO:1990293 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990293 GO:1990294 biolink:BiologicalProcess peptidyl-threonine trans-autophosphorylation The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer. go.json http://purl.obolibrary.org/obo/GO_1990294 gocheck_do_not_annotate GO:0015715 biolink:BiologicalProcess nucleotide-sulfate transport The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json nucleotide-sulphate transport http://purl.obolibrary.org/obo/GO_0015715 GO:0015716 biolink:BiologicalProcess organic phosphonate transport The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). go.json alkylphosphonate transport http://purl.obolibrary.org/obo/GO_0015716 GO:0015717 biolink:BiologicalProcess triose phosphate transport The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json aldotriose phosphate transport http://purl.obolibrary.org/obo/GO_0015717 GO:1990290 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990290 GO:0015718 biolink:BiologicalProcess monocarboxylic acid transport The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015718 GO:0015711 biolink:BiologicalProcess organic anion transport The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. go.json http://purl.obolibrary.org/obo/GO_0015711 GO:0015712 biolink:BiologicalProcess hexose phosphate transport The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015712 GO:0015713 biolink:BiologicalProcess phosphoglycerate transmembrane transport The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other. go.json phosphoglycerate transport http://purl.obolibrary.org/obo/GO_0015713 GO:0015714 biolink:BiologicalProcess phosphoenolpyruvate transport The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015714 GO:0015710 biolink:BiologicalProcess tellurite transport The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015710 GO:0050121 biolink:MolecularActivity N-acylglucosamine 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. EC:5.1.3.8|MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN|RHEA:19033|Reactome:R-HSA-6803761 go.json GlcNAc 2-epimerase activity|N-acetyl-D-glucosamine 2-epimerase activity|N-acetylglucosamine 2-epimerase activity|N-acyl-D-glucosamine 2-epimerase activity|acylglucosamine 2-epimerase activity http://purl.obolibrary.org/obo/GO_0050121 GO:0050122 biolink:MolecularActivity N-acylhexosamine oxidase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + O2 = N-acetyl-D-glucosaminate + H2O2 + H+. EC:1.1.3.29|KEGG_REACTION:R01203|MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN|RHEA:13029 go.json N-acyl-D-hexosamine oxidase activity|N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity|N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050122 GO:0050120 biolink:MolecularActivity N-acetylhexosamine 1-dehydrogenase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH. EC:1.1.1.240|KEGG_REACTION:R01202|MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN|RHEA:23144 go.json N-acetyl-D-hexosamine dehydrogenase activity|N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity|N-acetylhexosamine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050120 GO:0050136 biolink:MolecularActivity NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. EC:1.6.5.11|MetaCyc:1.6.99.5-RXN|RHEA:46160 go.json D-diaphorase activity|DPNH-menadione reductase activity|NADH-quinone oxidoreductase activity|NADH:(quinone-acceptor) oxidoreductase activity|reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity http://purl.obolibrary.org/obo/GO_0050136 GO:0050137 biolink:MolecularActivity NADPH peroxidase activity Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+. EC:1.11.1.2|KEGG_REACTION:R00113|MetaCyc:NADPH-PEROXIDASE-RXN|RHEA:15173 go.json NADP peroxidase activity|NADPH:hydrogen-peroxide oxidoreductase activity|TPN peroxidase activity|TPNH peroxidase activity|nicotinamide adenine dinucleotide phosphate peroxidase activity|triphosphopyridine nucleotide peroxidase activity http://purl.obolibrary.org/obo/GO_0050137 GO:0050134 biolink:MolecularActivity N6-methyl-lysine oxidase activity Catalysis of the reaction: N(6)-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2. EC:1.5.3.4|KEGG_REACTION:R00612|MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN|RHEA:23200 go.json 6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)|N(6)-methyllysine oxidase activity|N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)|N6-methyllysine oxidase activity|epsilon-N-methyllysine demethylase activity|epsilon-alkyl-L-lysine:oxygen oxidoreductase activity|epsilon-alkyllysinase activity http://purl.obolibrary.org/obo/GO_0050134 GO:0050135 biolink:MolecularActivity NAD(P)+ nucleosidase activity Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide. EC:3.2.2.6|MetaCyc:NADNUCLEOSID-RXN go.json NAD(P) nucleosidase activity|NAD(P)(+) nucleosidase activity|NAD(P)+ glycohydrolase activity|NAD(P)ase activity|nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity|nicotinamide adenine dinucleotide (phosphate) nucleosidase activity|triphosphopyridine nucleotidase activity http://purl.obolibrary.org/obo/GO_0050135 GO:0050138 biolink:MolecularActivity nicotinate dehydrogenase activity Catalysis of the reaction: H2O + NADP+ + nicotinate = 6-hydroxynicotinate + H+ + NADPH. EC:1.17.1.5|KEGG_REACTION:R01720|MetaCyc:NICOTINATE-DEHYDROGENASE-RXN|MetaCyc:RXN-7637|RHEA:12236 go.json nicotinate hydroxylase activity|nicotinate:NADP+ 6-oxidoreductase (hydroxylating)|nicotinic acid hydroxylase activity http://purl.obolibrary.org/obo/GO_0050138 GO:0050139 biolink:MolecularActivity nicotinate-N-glucosyltransferase activity Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP. EC:2.4.1.196|KEGG_REACTION:R01722|MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN|RHEA:19437 go.json UDP-glucose:nicotinate N-glucosyltransferase activity|UDP-glucose:nicotinic acid-N-glucosyltransferase activity|UDPglucose:nicotinate N-glucosyltransferase activity|nicotinate glucosyltransferase activity|uridine diphosphoglucose-nicotinate N-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0050139 GO:0015726 biolink:BiologicalProcess L-idonate transmembrane transport The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. go.json L-idonate transport http://purl.obolibrary.org/obo/GO_0015726 GO:0015727 biolink:BiologicalProcess lactate transport The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. go.json http://purl.obolibrary.org/obo/GO_0015727 GO:0015728 biolink:BiologicalProcess mevalonate transport The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015728 GO:0015729 biolink:BiologicalProcess oxaloacetate transport The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015729 GO:0015722 biolink:BiologicalProcess canalicular bile acid transport Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. go.json http://purl.obolibrary.org/obo/GO_0015722 GO:0015723 biolink:BiologicalProcess bilirubin transport The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015723 GO:0015724 biolink:BiologicalProcess formate transport The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0015724 GO:0015725 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0015725 GO:0015720 biolink:BiologicalProcess allantoin transport The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json allantoin transmembrane transport|allantoin/allantoate transport http://purl.obolibrary.org/obo/GO_0015720 GO:0015721 biolink:BiologicalProcess bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json bile acid transport|bile salt transport http://purl.obolibrary.org/obo/GO_0015721 GO:0050132 biolink:MolecularActivity N-methylalanine dehydrogenase activity Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate. EC:1.4.1.17|KEGG_REACTION:R01584|MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN|RHEA:21768 go.json N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating) http://purl.obolibrary.org/obo/GO_0050132 GO:0050133 biolink:MolecularActivity N6-hydroxylysine O-acetyltransferase activity Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA. EC:2.3.1.102|KEGG_REACTION:R03168|MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN|RHEA:22388 go.json N(6)-hydroxylysine acetylase activity|N6-hydroxylysine acetylase activity|N6-hydroxylysine:acetyl CoA N6-transacetylase activity|acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity|acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0050133 GO:0050130 biolink:MolecularActivity N-methyl-2-oxoglutaramate hydrolase activity Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylammonium. EC:3.5.1.36|KEGG_REACTION:R01587|MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN|RHEA:24108 go.json 5-hydroxy-N-methylpyroglutamate synthase activity|N-methyl-2-oxoglutaramate methylamidohydrolase activity http://purl.obolibrary.org/obo/GO_0050130 GO:0050131 biolink:MolecularActivity N-methyl-L-amino-acid oxidase activity Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2. EC:1.5.3.2|MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN|RHEA:11472 go.json N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)|N-methylamino acid oxidase activity http://purl.obolibrary.org/obo/GO_0050131 GO:1990233 biolink:CellularComponent intramolecular phosphotransferase complex A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule. go.json http://purl.obolibrary.org/obo/GO_1990233 GO:1990234 biolink:CellularComponent transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). go.json http://purl.obolibrary.org/obo/GO_1990234 GO:1990235 biolink:CellularComponent diamine N-acetyltransferase complex A protein complex which is capable of diamine N-acetyltransferase activity. go.json SAT complex|SAT tetramer|spermidine acetyltransferase complex http://purl.obolibrary.org/obo/GO_1990235 GO:1990236 biolink:BiologicalProcess proteasome core complex import into nucleus The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus. go.json http://purl.obolibrary.org/obo/GO_1990236 GO:1990230 biolink:CellularComponent iron-sulfur cluster transfer complex A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor). go.json Fe-S cluster transfer complex|IscA complex|SufA complex|SufA dimer http://purl.obolibrary.org/obo/GO_1990230 GO:1990231 biolink:CellularComponent STING complex A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. go.json stimulator of interferon genes complex http://purl.obolibrary.org/obo/GO_1990231 GO:1990232 biolink:CellularComponent phosphomannomutase complex A protein complex capable of phosphomannomutase activity. go.json PMM-1 complex|PMM-1 dimer|PMM-2 complex|PMM-2 dimer http://purl.obolibrary.org/obo/GO_1990232 BFO:0000050 biolink:OntologyClass part of BFO:0000050 go.json http://purl.obolibrary.org/obo/BFO_0000050 BFO:0000051 biolink:OntologyClass has part BFO:0000051 go.json http://purl.obolibrary.org/obo/BFO_0000051 GO:1990237 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990237 GO:1990238 biolink:MolecularActivity double-stranded DNA endonuclease activity Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. go.json double-stranded DNA endodeoxyribonuclease activity|dsDNA-specific endodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_1990238 GO:1990239 biolink:MolecularActivity steroid hormone binding Binding to a steroid hormone. go.json http://purl.obolibrary.org/obo/GO_1990239 GO:1990244 biolink:MolecularActivity histone H2AT120 kinase activity Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A. go.json histone H2A-T120 kinase activity|histone kinase activity (H2A-T120 specific)|histone threonine kinase activity (H2A-T120 specific) http://purl.obolibrary.org/obo/GO_1990244 GO:1990245 biolink:BiologicalProcess obsolete histone H2A-T120 phosphorylation OBSOLETE. The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone. go.json histone H2A phosphorylation at T120|histone H2AT120 phosphorylation True http://purl.obolibrary.org/obo/GO_1990245 GO:1990246 biolink:CellularComponent uniplex complex A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. go.json mitochondrial uniporter complex|mitochondrial uniporter holocomplex http://purl.obolibrary.org/obo/GO_1990246 GO:1990247 biolink:MolecularActivity N6-methyladenosine-containing RNA reader activity A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. go.json N6-methyladenosine-containing RNA binding http://purl.obolibrary.org/obo/GO_1990247 GO:1990240 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1990240 GO:1990241 biolink:CellularComponent obsolete nucleotide binding complex OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6). go.json nucleotide binding complex True http://purl.obolibrary.org/obo/GO_1990241 GO:1990242 biolink:CellularComponent obsolete innate immune response complex OBSOLETE. A protein complex involved in the innate immune response. go.json innate immune response complex True http://purl.obolibrary.org/obo/GO_1990242 GO:1990243 biolink:CellularComponent atf1-pcr1 complex A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE). go.json http://purl.obolibrary.org/obo/GO_1990243 GO:1990248 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to DNA damage OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage. go.json True http://purl.obolibrary.org/obo/GO_1990248 GO:1990249 biolink:CellularComponent nucleotide-excision repair, DNA damage recognition complex A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex. go.json http://purl.obolibrary.org/obo/GO_1990249 GO:1990255 biolink:BiologicalProcess subsynaptic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. go.json http://purl.obolibrary.org/obo/GO_1990255 GO:1990256 biolink:BiologicalProcess signal clustering Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response. go.json ligand clustering http://purl.obolibrary.org/obo/GO_1990256 GO:1990257 biolink:CellularComponent piccolo-bassoon transport vesicle A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon. go.json PTV http://purl.obolibrary.org/obo/GO_1990257 GO:1990258 biolink:BiologicalProcess histone glutamine methylation The modification of a histone by addition of a methyl group to an glutamine residue. go.json http://purl.obolibrary.org/obo/GO_1990258 gocheck_do_not_annotate GO:0001198 biolink:BiologicalProcess obsolete negative regulation of mating-type specific transcription from RNA polymerase II promoter OBSOLETE. Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. go.json down regulation of RNA polymerase II transcription, mating-type specific|down-regulation of RNA polymerase II transcription, mating-type specific|downregulation of RNA polymerase II transcription, mating-type specific|inhibition of RNA polymerase II transcription, mating-type specific True http://purl.obolibrary.org/obo/GO_0001198 GO:1990251 biolink:CellularComponent nuclear exosome focus An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome. go.json Mmi1 nuclear focus|nuclear body http://purl.obolibrary.org/obo/GO_1990251 GO:0001199 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001199 GO:1990252 biolink:CellularComponent Syp1 complex A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis. go.json Syp1 dimer http://purl.obolibrary.org/obo/GO_1990252 GO:1990253 biolink:BiologicalProcess cellular response to leucine starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine. go.json http://purl.obolibrary.org/obo/GO_1990253 GO:1990254 biolink:MolecularActivity keratin filament binding Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. go.json http://purl.obolibrary.org/obo/GO_1990254 GO:0001194 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001194 GO:0001195 biolink:BiologicalProcess maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter. go.json maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter|maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0001195 GO:0001196 biolink:BiologicalProcess obsolete regulation of mating-type specific transcription from RNA polymerase II promoter OBSOLETE. Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0001196 GO:0001197 biolink:BiologicalProcess obsolete positive regulation of mating-type specific transcription from RNA polymerase II promoter OBSOLETE. Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter. go.json activation of transcription from an RNA polymerase II promoter, mating-type specific|stimulation of transcription from an RNA polymerase II promoter, mating-type specific|up regulation of transcription from an RNA polymerase II promoter, mating-type specific|up-regulation of transcription from an RNA polymerase II promoter, mating-type specific|upregulation of transcription from an RNA polymerase II promoter, mating-type specific True http://purl.obolibrary.org/obo/GO_0001197 GO:1990250 biolink:CellularComponent transcription-coupled nucleotide-excision repair, DNA damage recognition complex A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex. go.json http://purl.obolibrary.org/obo/GO_1990250 GO:0001190 biolink:MolecularActivity obsolete transcriptional activator activity, RNA polymerase II transcription factor binding OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json RNA polymerase II transcription factor binding transcription activator activity|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription True http://purl.obolibrary.org/obo/GO_0001190 GO:0001191 biolink:MolecularActivity obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcription factor binding transcription repressor activity|RNA polymerase II transcription repressor activity True http://purl.obolibrary.org/obo/GO_0001191 GO:0001192 biolink:BiologicalProcess maintenance of transcriptional fidelity during transcription elongation Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template. go.json maintenance of transcriptional fidelity during DNA-dependent transcription elongation|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter|maintenance of transcriptional fidelity during DNA-templated transcription elongation|maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter http://purl.obolibrary.org/obo/GO_0001192 GO:0001193 biolink:BiologicalProcess maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter. go.json maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0001193 GO:1990259 biolink:MolecularActivity histone H2AQ104 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast. go.json histone glutamine N-methyltransferase activity|histone glutamine methylase activity|histone glutamine methyltransferase activity|histone-glutamine N-methyltransferase activity|histone-glutamine methyltransferase activity http://purl.obolibrary.org/obo/GO_1990259 GO:1990266 biolink:BiologicalProcess neutrophil migration The movement of a neutrophil within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_1990266 GO:1990267 biolink:BiologicalProcess response to transition metal nanoparticle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. go.json response to colloidal metal|response to neutral metal atoms http://purl.obolibrary.org/obo/GO_1990267 GO:1990268 biolink:BiologicalProcess response to gold nanoparticle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus. go.json http://purl.obolibrary.org/obo/GO_1990268 GO:1990269 biolink:MolecularActivity RNA polymerase II C-terminal domain phosphoserine binding Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II. go.json RNA Pol II C-terminal domain phosphoserine binding|RNAP II C-terminal domain phosphoserine binding http://purl.obolibrary.org/obo/GO_1990269 GO:1990262 biolink:BiologicalProcess anti-Mullerian hormone signaling pathway The series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json http://purl.obolibrary.org/obo/GO_1990262 GO:1990263 biolink:BiologicalProcess spore wall assembly MAPK cascade A MAPK cascade that occurs as a result of deprivation of nourishment. go.json MAPK cascade in response to starvation|MAPK cascade involved in nutrient response signaling http://purl.obolibrary.org/obo/GO_1990263 GO:1990264 biolink:BiologicalProcess peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity. go.json http://purl.obolibrary.org/obo/GO_1990264 gocheck_do_not_annotate GO:1990265 biolink:CellularComponent platelet-derived growth factor complex A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). go.json PDGF complex|PDGF-AA dimer|PDGF-AB dimer|PDGF-BB dimer|PDGF-CC dimer|PDGF-DD dimer http://purl.obolibrary.org/obo/GO_1990265 GO:1990260 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling. go.json True http://purl.obolibrary.org/obo/GO_1990260 GO:1990261 biolink:BiologicalProcess pre-mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA). go.json pre-mRNA decay|unspliced RNA decay http://purl.obolibrary.org/obo/GO_1990261 BFO:0000066 biolink:OntologyClass occurs in BFO:0000066 go.json http://purl.obolibrary.org/obo/BFO_0000066 BFO:0000062 biolink:OntologyClass preceded by BFO:0000062 go.json http://purl.obolibrary.org/obo/BFO_0000062 BFO:0000063 biolink:OntologyClass precedes BFO:0000063 go.json http://purl.obolibrary.org/obo/BFO_0000063 GO:0001176 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001176 GO:0001177 biolink:BiologicalProcess regulation of transcription open complex formation at RNA polymerase II promoter Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. go.json regulation of transcriptional open complex formation at RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0001177 GO:0001178 biolink:BiologicalProcess regulation of transcriptional start site selection at RNA polymerase II promoter Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. go.json regulation of transcription start site selection at RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0001178 GO:0001179 biolink:MolecularActivity RNA polymerase I general transcription initiation factor binding Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I. go.json RNA polymerase I transcription factor binding http://purl.obolibrary.org/obo/GO_0001179 GO:0001172 biolink:BiologicalProcess RNA-templated transcription The synthesis of an RNA transcript from an RNA template. go.json transcription, RNA-dependent|transcription, RNA-templated http://purl.obolibrary.org/obo/GO_0001172 GO:0001173 biolink:BiologicalProcess DNA-templated transcriptional start site selection Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. go.json DNA-dependent transcriptional start site selection|transcriptional start site selection at bacterial-type RNA polymerase promoter http://purl.obolibrary.org/obo/GO_0001173 GO:0001174 biolink:BiologicalProcess transcriptional start site selection at RNA polymerase II promoter Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. go.json http://purl.obolibrary.org/obo/GO_0001174 GO:0001175 biolink:BiologicalProcess transcriptional start site selection at RNA polymerase III promoter Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. go.json http://purl.obolibrary.org/obo/GO_0001175 GO:0001170 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding OBSOLETE. Binding to a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I. go.json RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001170 GO:0001171 biolink:BiologicalProcess reverse transcription A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis. Wikipedia:Reverse_transcription go.json http://purl.obolibrary.org/obo/GO_0001171 GO:1990200 biolink:CellularComponent SsuD-SsuE complex A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation. go.json two-component alkanesulfonate monooxygenase system http://purl.obolibrary.org/obo/GO_1990200 GO:1990201 biolink:CellularComponent alkanesulfonate monooxygenase complex A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer. go.json SsuD complex http://purl.obolibrary.org/obo/GO_1990201 GO:1990202 biolink:CellularComponent FMN reductase complex A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer. go.json FMN oxidoreductase complex, NAD(P)H-dependent|FMN reductase complex, NAD(P)H-dependent|SsuE complex|flavin oxidoreductase complex, NAD(P)H-dependent http://purl.obolibrary.org/obo/GO_1990202 GO:1990203 biolink:CellularComponent MdtBC Complex A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane. go.json multidrug efflux pump MdtBC http://purl.obolibrary.org/obo/GO_1990203 GO:0001187 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001187 GO:0001188 biolink:BiologicalProcess RNA polymerase I preinitiation complex assembly The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which includes including UBF, SL1, RRN3 and TBP in human). The PIC engages RNA polymerase I on its DNA template strand and sparks polymerization of the first few RNA nucleotides. go.json RNA polymerase I transcriptional preinitiation complex assembly|RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript|RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript http://purl.obolibrary.org/obo/GO_0001188 GO:0001189 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001189 GO:0001183 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001183 GO:0001184 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001184 GO:0001185 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001185 GO:0001186 biolink:MolecularActivity obsolete RNA polymerase I transcription regulator recruiting activity OBSOLETE. The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation. go.json RNA polymerase I transcription factor recruiting activity|RNA polymerase I transcription factor recruiting transcription factor activity|transcription factor activity, RNA polymerase I transcription factor recruiting True http://purl.obolibrary.org/obo/GO_0001186 GO:0001180 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001180 GO:0001181 biolink:MolecularActivity RNA polymerase I general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs. go.json RNA polymerase I transcription general initiation factor activity|core RNA polymerase I binding transcription factor activity|general RNA polymerase I transcription factor activity|transcription factor activity, core RNA polymerase I binding http://purl.obolibrary.org/obo/GO_0001181 GO:0001182 biolink:BiologicalProcess RNA polymerase I promoter clearance A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. go.json RNA polymerase I promoter escape|promoter clearance from RNA polymerase I promoter|promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript http://purl.obolibrary.org/obo/GO_0001182 GO:1990208 biolink:BiologicalProcess obsolete positive regulation by symbiont of RNA levels in host OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_1990208 GO:1990209 biolink:BiologicalProcess obsolete negative regulation by symbiont of RNA levels in host OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_1990209 GO:1990204 biolink:CellularComponent oxidoreductase complex Any protein complex that possesses oxidoreductase activity. go.json oxidation-reduction complex|redox complex http://purl.obolibrary.org/obo/GO_1990204 goslim_metagenomics GO:1990205 biolink:CellularComponent taurine dioxygenase complex A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD. go.json 2-aminoethanesulfonate dioxygenase complex|TauD complex|alpha-ketoglutarate-dependent taurine dioxygenase complex http://purl.obolibrary.org/obo/GO_1990205 GO:1990206 biolink:MolecularActivity jasmonyl-Ile conjugate hydrolase activity Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine. go.json JA-Ile hydrolase http://purl.obolibrary.org/obo/GO_1990206 GO:1990207 biolink:CellularComponent EmrE multidrug transporter complex A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer. go.json EmrE complex http://purl.obolibrary.org/obo/GO_1990207 GO:0001158 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001158 GO:1990211 biolink:BiologicalProcess positive regulation by symbiont of jasmonic acid levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990211 GO:0001159 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001159 GO:1990212 biolink:BiologicalProcess positive regulation by symbiont of ethylene levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990212 GO:1990213 biolink:BiologicalProcess negative regulation by symbiont of salicylic acid levels in host Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990213 GO:1990214 biolink:BiologicalProcess obsolete negative regulation by symbiont of host protein levels OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_1990214 GO:0001154 biolink:MolecularActivity TFIIIB-class transcription factor complex binding Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. go.json TFIIIB-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001154 GO:0001155 biolink:MolecularActivity TFIIIA-class transcription factor binding Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters. go.json http://purl.obolibrary.org/obo/GO_0001155 GO:0001156 biolink:MolecularActivity TFIIIC-class transcription factor complex binding Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. go.json TFIIIC-class transcription factor binding http://purl.obolibrary.org/obo/GO_0001156 GO:1990210 biolink:BiologicalProcess positive regulation by symbiont of indole acetic acid levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of IAA levels in host|positive regulation by symbiont of auxin levels in host http://purl.obolibrary.org/obo/GO_1990210 GO:0001157 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001157 GO:0001150 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001150 GO:0001151 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001151 GO:0001152 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter. go.json RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity|TFIIIA activity|type 1 RNA polymerase III promoter recognition True http://purl.obolibrary.org/obo/GO_0001152 GO:0001153 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase III transcription factor recruiting OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III. go.json RNA polymerase III transcription factor recruiting transcription factor activity True http://purl.obolibrary.org/obo/GO_0001153 GO:0015799 biolink:BiologicalProcess propanediol transport The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. go.json http://purl.obolibrary.org/obo/GO_0015799 GO:0015795 biolink:BiologicalProcess sorbitol transmembrane transport The directed movement of sorbitol across a membrane. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. go.json glucitol transport|sorbitol transport http://purl.obolibrary.org/obo/GO_0015795 GO:0015796 biolink:BiologicalProcess galactitol transmembrane transport The directed movement of galactitol across a membrane. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. go.json galactitol transport http://purl.obolibrary.org/obo/GO_0015796 GO:0015797 biolink:BiologicalProcess mannitol transmembrane transport The directed movement of mannitol across a membrane. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. go.json mannitol transport http://purl.obolibrary.org/obo/GO_0015797 GO:0015798 biolink:BiologicalProcess myo-inositol transport The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. go.json vitamin Bh transport http://purl.obolibrary.org/obo/GO_0015798 GO:0015791 biolink:BiologicalProcess polyol transmembrane transport The directed movement of polyols, any polyhydric alcohol, across a membrane. go.json http://purl.obolibrary.org/obo/GO_0015791 goslim_pir GO:1990219 biolink:BiologicalProcess obsolete positive regulation by symbiont of host protein levels OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_1990219 GO:0015792 biolink:BiologicalProcess arabinitol transmembrane transport The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. go.json arabinitol transport|arabitol transport http://purl.obolibrary.org/obo/GO_0015792 GO:0015793 biolink:BiologicalProcess glycerol transmembrane transport The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. go.json glycerol transport http://purl.obolibrary.org/obo/GO_0015793 GO:0015794 biolink:BiologicalProcess glycerol-3-phosphate transmembrane transport The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. go.json glycerol-3-phosphate transport http://purl.obolibrary.org/obo/GO_0015794 GO:1990215 biolink:BiologicalProcess negative regulation by symbiont of host intracellular transport Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990215 GO:1990216 biolink:BiologicalProcess positive regulation by symbiont of host transcription Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990216 GO:1990217 biolink:BiologicalProcess suppression by symbiont of host phytoalexin production Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by symbiont of host phytoalexin production http://purl.obolibrary.org/obo/GO_1990217 GO:0015790 biolink:BiologicalProcess UDP-xylose transmembrane transport The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. go.json UDP-xylose transport http://purl.obolibrary.org/obo/GO_0015790 GO:1990218 biolink:BiologicalProcess positive regulation by symbiont of abscisic acid levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990218 GO:1990222 biolink:CellularComponent ProVWX complex The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions. go.json ATP-binding cassette (ABC) transporter complex ProVWX http://purl.obolibrary.org/obo/GO_1990222 GO:0001169 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding OBSOLETE. Binding to CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I. go.json RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity|RNA polymerase I core promoter sequence-specific DNA binding transcription factor True http://purl.obolibrary.org/obo/GO_0001169 GO:1990223 biolink:BiologicalProcess positive regulation by symbiont of cytokinin levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_1990223 GO:1990224 biolink:MolecularActivity NMN phosphatase activity Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate. RHEA:30815 go.json beta-nicotinamide D-ribonucleotide phosphatase activity|nicotinamide mononucleotide phosphatase activity http://purl.obolibrary.org/obo/GO_1990224 GO:1990225 biolink:CellularComponent rhoptry neck Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion. go.json http://purl.obolibrary.org/obo/GO_1990225 GO:0001165 biolink:MolecularActivity RNA polymerase I cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element). go.json RNA polymerase I enhancer sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream element sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001165 GO:0001166 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001166 GO:1990220 biolink:CellularComponent GroEL-GroES complex Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins. go.json bacterial chaperonin ATPase complex|bacterial chaperonin complex http://purl.obolibrary.org/obo/GO_1990220 GO:0001167 biolink:MolecularActivity obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding OBSOLETE. Binding to a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. go.json sequence-specific DNA binding RNA polymerase I transcription factor activity True http://purl.obolibrary.org/obo/GO_0001167 GO:1990221 biolink:CellularComponent L-cysteine desulfurase complex A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer. go.json IscS|NifS|SufS complex http://purl.obolibrary.org/obo/GO_1990221 GO:0001168 biolink:MolecularActivity obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding OBSOLETE. Binding to a upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I. go.json RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0001168 GO:0001161 biolink:MolecularActivity intronic transcription regulatory region sequence-specific DNA binding Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within. go.json intronic transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0001161 GO:0001162 biolink:MolecularActivity RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. go.json http://purl.obolibrary.org/obo/GO_0001162 GO:0001163 biolink:MolecularActivity RNA polymerase I transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I. go.json RNA polymerase I regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0001163 GO:0001164 biolink:MolecularActivity RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. go.json RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting http://purl.obolibrary.org/obo/GO_0001164 GO:0001160 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0001160 GO:1990226 biolink:MolecularActivity histone methyltransferase binding Binding to a histone methyltransferase enzyme. go.json http://purl.obolibrary.org/obo/GO_1990226 GO:1990227 biolink:BiologicalProcess paranodal junction maintenance The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. go.json axoglial septate junction maintenance|paranodal axoglial junction maintenance|paranodal septate maintenance http://purl.obolibrary.org/obo/GO_1990227 GO:1990228 biolink:CellularComponent sulfurtransferase complex A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). go.json SufE complex|SufE dimer|ThiF-ThiS complex|sulfur transfer complex http://purl.obolibrary.org/obo/GO_1990228 GO:1990229 biolink:CellularComponent iron-sulfur cluster assembly complex A protein complex capable of assembling an iron-sulfur (Fe-S) cluster. go.json Fe-S cluster assembly complex|SufBCD complex http://purl.obolibrary.org/obo/GO_1990229 GO:0019460 biolink:BiologicalProcess glutamine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate. go.json glutamate catabolic process to fumarate|glutamine breakdown to fumarate|glutamine degradation to fumarate http://purl.obolibrary.org/obo/GO_0019460 GO:0044423 biolink:CellularComponent virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle. Wikipedia:Virus go.json complete virus particle|virion|virion part http://purl.obolibrary.org/obo/GO_0044423 goslim_chembl|goslim_metagenomics|goslim_pir GO:0044424 biolink:CellularComponent obsolete intracellular part OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. go.json True http://purl.obolibrary.org/obo/GO_0044424 GO:0044421 biolink:CellularComponent obsolete extracellular region part OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite. go.json extracellular structure True http://purl.obolibrary.org/obo/GO_0044421 GO:0044422 biolink:CellularComponent obsolete organelle part OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane. go.json True http://purl.obolibrary.org/obo/GO_0044422 GO:0044420 biolink:CellularComponent obsolete extracellular matrix component OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). go.json extracellular matrix part True http://purl.obolibrary.org/obo/GO_0044420 GO:0044429 biolink:CellularComponent obsolete mitochondrial part OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. go.json mitochondrial subcomponent|mitochondrion component True http://purl.obolibrary.org/obo/GO_0044429 GO:0044427 biolink:CellularComponent obsolete chromosomal part OBSOLETE. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. go.json chromosomal component|chromosome component|chromosome part True http://purl.obolibrary.org/obo/GO_0044427 GO:0044428 biolink:CellularComponent obsolete nuclear part OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. go.json nuclear subcomponent|nucleus component True http://purl.obolibrary.org/obo/GO_0044428 GO:0019458 biolink:BiologicalProcess methionine catabolic process via 2-oxobutanoate The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate. MetaCyc:PWY-701 go.json methionine breakdown via 2-oxobutanoate|methionine degradation via 2-oxobutanoate http://purl.obolibrary.org/obo/GO_0019458 GO:0044425 biolink:CellularComponent obsolete membrane part OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. go.json True http://purl.obolibrary.org/obo/GO_0044425 GO:0044426 biolink:CellularComponent obsolete cell wall part OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. go.json True http://purl.obolibrary.org/obo/GO_0044426 GO:0019459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019459 GO:0019456 biolink:BiologicalProcess L-cysteine catabolic process via cystine, using cysteine transaminase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase. go.json L-cysteine breakdown via cystine, using cysteine transaminase|L-cysteine degradation via cystine, using cysteine transaminase http://purl.obolibrary.org/obo/GO_0019456 GO:0019457 biolink:BiologicalProcess methionine catabolic process to succinyl-CoA The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA. MetaCyc:METHIONINE-DEG1-PWY go.json methionine breakdown to succinyl-CoA|methionine degradation to succinyl-CoA http://purl.obolibrary.org/obo/GO_0019457 GO:0019454 biolink:BiologicalProcess L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase. go.json L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase|L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase http://purl.obolibrary.org/obo/GO_0019454 GO:0019455 biolink:BiologicalProcess L-cysteine catabolic process via cystine, using cystine reductase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase. go.json L-cysteine breakdown via cystine, using cystine reductase|L-cysteine degradation via cystine, using cystine reductase http://purl.obolibrary.org/obo/GO_0019455 GO:0019452 biolink:BiologicalProcess L-cysteine catabolic process to taurine The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine. go.json L-cysteine breakdown to taurine|L-cysteine degradation to taurine http://purl.obolibrary.org/obo/GO_0019452 GO:0019453 biolink:BiologicalProcess L-cysteine catabolic process via cystine The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine. go.json L-cysteine breakdown via cystine|L-cysteine degradation via cystine http://purl.obolibrary.org/obo/GO_0019453 GO:0019450 biolink:BiologicalProcess L-cysteine catabolic process to pyruvate The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate. MetaCyc:LCYSDEG-PWY go.json L-cysteine breakdown to pyruvate|L-cysteine degradation to pyruvate http://purl.obolibrary.org/obo/GO_0019450 GO:0019451 biolink:BiologicalProcess L-cysteine catabolic process to pyruvate, using cysteine dioxygenase The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20). MetaCyc:CYSTEINE-DEG-PWY go.json L-cysteine breakdown to pyruvate, using cysteine dioxygenase|L-cysteine degradation to pyruvate, using cysteine dioxygenase http://purl.obolibrary.org/obo/GO_0019451 GO:0019470 biolink:BiologicalProcess 4-hydroxyproline catabolic process The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. MetaCyc:HYDROXYPRODEG-PWY go.json 4-hydroxyproline breakdown|4-hydroxyproline catabolism|4-hydroxyproline degradation http://purl.obolibrary.org/obo/GO_0019470 GO:0019471 biolink:BiologicalProcess 4-hydroxyproline metabolic process The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. go.json 4-hydroxyproline metabolism http://purl.obolibrary.org/obo/GO_0019471 GO:0044434 biolink:CellularComponent obsolete chloroplast part OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. go.json True http://purl.obolibrary.org/obo/GO_0044434 GO:0044435 biolink:CellularComponent obsolete plastid part OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. go.json True http://purl.obolibrary.org/obo/GO_0044435 GO:0044432 biolink:CellularComponent obsolete endoplasmic reticulum part OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. go.json ER component True http://purl.obolibrary.org/obo/GO_0044432 GO:0044433 biolink:CellularComponent obsolete cytoplasmic vesicle part OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. go.json True http://purl.obolibrary.org/obo/GO_0044433 GO:0044430 biolink:CellularComponent obsolete cytoskeletal part OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. NIF_Subcellular:sao1635329413 go.json cytoskeletal element|cytoskeleton component True http://purl.obolibrary.org/obo/GO_0044430 GO:0044431 biolink:CellularComponent obsolete Golgi apparatus part OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. go.json Golgi component|Golgi subcomponent True http://purl.obolibrary.org/obo/GO_0044431 GO:0044438 biolink:CellularComponent obsolete microbody part OBSOLETE. Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). go.json True http://purl.obolibrary.org/obo/GO_0044438 GO:0044439 biolink:CellularComponent obsolete peroxisomal part OBSOLETE. Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). go.json peroxisome component True http://purl.obolibrary.org/obo/GO_0044439 GO:0019469 biolink:BiologicalProcess octopine catabolic process The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine. MetaCyc:OCTOPINEDEG-PWY go.json octopine breakdown|octopine catabolism|octopine degradation http://purl.obolibrary.org/obo/GO_0019469 GO:0044436 biolink:CellularComponent obsolete thylakoid part OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms. go.json True http://purl.obolibrary.org/obo/GO_0044436 GO:0044437 biolink:CellularComponent obsolete vacuolar part OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. go.json vacuole component True http://purl.obolibrary.org/obo/GO_0044437 GO:0019467 biolink:BiologicalProcess ornithine catabolic process, by decarboxylation The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation. MetaCyc:ORNDEG-PWY go.json ornithine breakdown, by decarboxylation|ornithine degradation, by decarboxylation http://purl.obolibrary.org/obo/GO_0019467 GO:0019468 biolink:BiologicalProcess nopaline catabolic process The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative. MetaCyc:NOPALINEDEG-PWY go.json nopaline breakdown|nopaline catabolism|nopaline degradation http://purl.obolibrary.org/obo/GO_0019468 GO:0019465 biolink:BiologicalProcess aspartate transamidation The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group. MetaCyc:ASPARTATE-DEG1-PWY|MetaCyc:ASPARTATESYN-PWY go.json http://purl.obolibrary.org/obo/GO_0019465 GO:0019466 biolink:BiologicalProcess ornithine catabolic process via proline The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline. MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY go.json ornithine breakdown via proline|ornithine degradation via proline http://purl.obolibrary.org/obo/GO_0019466 GO:0019463 biolink:BiologicalProcess glycine catabolic process to creatine The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine. MetaCyc:GLYCGREAT-PWY go.json glycine breakdown to creatine|glycine degradation to creatine http://purl.obolibrary.org/obo/GO_0019463 GO:0019464 biolink:BiologicalProcess glycine decarboxylation via glycine cleavage system The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. MetaCyc:GLYCLEAV-PWY go.json glycine cleavage system http://purl.obolibrary.org/obo/GO_0019464 GO:0019461 biolink:BiologicalProcess glutamine catabolic process to fumarate, using glutamate synthase (NADPH) The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13). MetaCyc:GLUTAMINEFUM-PWY go.json glutamate catabolic process to fumarate, using glutamate synthase (NADPH)|glutamine breakdown to fumarate, using glutamate synthase (NADPH)|glutamine degradation to fumarate, using glutamate synthase (NADPH) http://purl.obolibrary.org/obo/GO_0019461 GO:0019462 biolink:BiologicalProcess glutamine catabolic process to fumarate, using glutaminase The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2). MetaCyc:GLUTAMINDEG-PWY go.json glutamate catabolic process to fumarate, using glutaminase|glutamine breakdown to fumarate, using glutaminase|glutamine degradation to fumarate, using glutaminase http://purl.obolibrary.org/obo/GO_0019462 GO:0044445 biolink:CellularComponent obsolete cytosolic part OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. go.json cytosol component True http://purl.obolibrary.org/obo/GO_0044445 GO:0044446 biolink:CellularComponent obsolete intracellular organelle part OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. go.json True http://purl.obolibrary.org/obo/GO_0044446 GO:0044443 biolink:CellularComponent obsolete pilus part OBSOLETE. Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. go.json fimbrial part|fimbrium component|pilus component True http://purl.obolibrary.org/obo/GO_0044443 GO:0044444 biolink:CellularComponent obsolete cytoplasmic part OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. go.json cytoplasm component True http://purl.obolibrary.org/obo/GO_0044444 GO:0044441 biolink:CellularComponent obsolete ciliary part OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. go.json cilial part|cilium part|flagellar part|flagellum component|flagellum part|microtubule-based flagellum part True http://purl.obolibrary.org/obo/GO_0044441 GO:0044442 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044442 GO:0044440 biolink:CellularComponent obsolete endosomal part OBSOLETE. Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. go.json endosomal subcomponent|endosome component True http://purl.obolibrary.org/obo/GO_0044440 GO:0019438 biolink:BiologicalProcess aromatic compound biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. go.json aromatic compound anabolism|aromatic compound biosynthesis|aromatic compound formation|aromatic compound synthesis|aromatic hydrocarbon biosynthesis|aromatic hydrocarbon biosynthetic process http://purl.obolibrary.org/obo/GO_0019438 GO:0044449 biolink:CellularComponent obsolete contractile fiber part OBSOLETE. Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. go.json contractile fibre component|muscle fiber component|muscle fibre component True http://purl.obolibrary.org/obo/GO_0044449 GO:0019439 biolink:BiologicalProcess aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. go.json aromatic compound breakdown|aromatic compound catabolism|aromatic compound degradation|aromatic hydrocarbon catabolic process|aromatic hydrocarbon catabolism http://purl.obolibrary.org/obo/GO_0019439 GO:0019436 biolink:BiologicalProcess sophorosyloxydocosanoate catabolic process The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate. MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY go.json sophorosyloxydocosanoate breakdown|sophorosyloxydocosanoate catabolism|sophorosyloxydocosanoate degradation http://purl.obolibrary.org/obo/GO_0019436 GO:0044447 biolink:CellularComponent obsolete axoneme part OBSOLETE. Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. go.json axonemal part True http://purl.obolibrary.org/obo/GO_0044447 GO:0044448 biolink:CellularComponent obsolete cell cortex part OBSOLETE. Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. go.json True http://purl.obolibrary.org/obo/GO_0044448 GO:0019434 biolink:BiologicalProcess sophorosyloxydocosanoate metabolic process The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon. go.json sophorosyloxydocosanoate metabolism http://purl.obolibrary.org/obo/GO_0019434 GO:0019435 biolink:BiologicalProcess sophorosyloxydocosanoate biosynthetic process The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate. MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY go.json sophorosyloxydocosanoate anabolism|sophorosyloxydocosanoate biosynthesis|sophorosyloxydocosanoate formation|sophorosyloxydocosanoate synthesis http://purl.obolibrary.org/obo/GO_0019435 GO:0019432 biolink:BiologicalProcess triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. MetaCyc:TRIGLSYN-PWY go.json triacylglycerol biosynthesis|triacylglycerol biosynthetic process|triglyceride anabolism|triglyceride biosynthesis|triglyceride formation|triglyceride synthesis http://purl.obolibrary.org/obo/GO_0019432 GO:0019433 biolink:BiologicalProcess triglyceride catabolic process The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. MetaCyc:LIPAS-PWY go.json triacylglycerol catabolic process|triacylglycerol catabolism|triglyceride breakdown|triglyceride catabolism|triglyceride degradation http://purl.obolibrary.org/obo/GO_0019433 GO:0019430 biolink:BiologicalProcess removal of superoxide radicals Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). MetaCyc:DETOX1-PWY go.json cellular detoxification of superoxide radicals|removal of O2-|removal of oxygen free radicals http://purl.obolibrary.org/obo/GO_0019430 GO:0019431 biolink:BiologicalProcess acetyl-CoA biosynthetic process from ethanol The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde. MetaCyc:ETOH-ACETYLCOA-ANA-PWY go.json acetyl-CoA anabolism from ethanol|acetyl-CoA formation from ethanol|acetyl-CoA synthesis from ethanol http://purl.obolibrary.org/obo/GO_0019431 GO:0044456 biolink:CellularComponent obsolete synapse part OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. NIF_Subcellular:sao1784069613 go.json synaptic component True http://purl.obolibrary.org/obo/GO_0044456 GO:0044457 biolink:CellularComponent obsolete cell septum part OBSOLETE. Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. go.json True http://purl.obolibrary.org/obo/GO_0044457 GO:0044454 biolink:CellularComponent obsolete nuclear chromosome part OBSOLETE. Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. go.json True http://purl.obolibrary.org/obo/GO_0044454 GO:0044455 biolink:CellularComponent obsolete mitochondrial membrane part OBSOLETE. Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. go.json True http://purl.obolibrary.org/obo/GO_0044455 GO:0044452 biolink:CellularComponent obsolete nucleolar part OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. go.json nucleolus component True http://purl.obolibrary.org/obo/GO_0044452 GO:0044453 biolink:CellularComponent obsolete nuclear membrane part OBSOLETE. Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. go.json True http://purl.obolibrary.org/obo/GO_0044453 GO:0044450 biolink:CellularComponent obsolete microtubule organizing center part OBSOLETE. Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. go.json MTOC component|microtubule organizing centre component True http://purl.obolibrary.org/obo/GO_0044450 GO:0044451 biolink:CellularComponent obsolete nucleoplasm part OBSOLETE. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. go.json True http://purl.obolibrary.org/obo/GO_0044451 GO:0019449 biolink:BiologicalProcess L-cysteine catabolic process to hypotaurine The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine. go.json L-cysteine breakdown to hypotaurine|L-cysteine degradation to hypotaurine http://purl.obolibrary.org/obo/GO_0019449 GO:0044458 biolink:BiologicalProcess motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a motile cilium. go.json motile primary cilia assembly|motile primary cilia formation|motile primary cilium assembly|motile primary cilium formation|nodal cilium assembly|nodal cilium formation http://purl.obolibrary.org/obo/GO_0044458 GO:0019447 biolink:BiologicalProcess D-cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin. go.json D-cysteine breakdown|D-cysteine catabolism|D-cysteine degradation http://purl.obolibrary.org/obo/GO_0019447 GO:0019448 biolink:BiologicalProcess L-cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. go.json L-cysteine breakdown|L-cysteine catabolism|L-cysteine degradation http://purl.obolibrary.org/obo/GO_0019448 GO:0044459 biolink:CellularComponent obsolete plasma membrane part OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. go.json True http://purl.obolibrary.org/obo/GO_0044459 GO:0019445 biolink:BiologicalProcess tyrosine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate. MetaCyc:TYRFUMCAT-PWY go.json tyrosine breakdown to fumarate|tyrosine degradation to fumarate http://purl.obolibrary.org/obo/GO_0019445 GO:0019446 biolink:BiologicalProcess obsolete tyrosine catabolic process to phosphoenolpyruvate OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate. go.json tyrosine breakdown to phosphoenolpyruvate|tyrosine degradation to phosphoenolpyruvate True http://purl.obolibrary.org/obo/GO_0019446 GO:0019443 biolink:BiologicalProcess obsolete tryptophan catabolic process, using tryptophanase OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1). go.json tryptophan breakdown, using tryptophanase|tryptophan catabolic process, using tryptophanase|tryptophan degradation, using tryptophanase True http://purl.obolibrary.org/obo/GO_0019443 GO:0019444 biolink:BiologicalProcess tryptophan catabolic process to catechol The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol. MetaCyc:TRPCAT-PWY go.json tryptophan breakdown to catechol|tryptophan degradation to catechol http://purl.obolibrary.org/obo/GO_0019444 GO:0019441 biolink:BiologicalProcess tryptophan catabolic process to kynurenine The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. MetaCyc:TRPKYNCAT-PWY go.json tryptophan breakdown to kynurenine|tryptophan degradation to kynurenine http://purl.obolibrary.org/obo/GO_0019441 GO:0019442 biolink:BiologicalProcess tryptophan catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. MetaCyc:TRYPTOPHAN-DEGRADATION-1 go.json tryptophan breakdown to acetyl-CoA|tryptophan degradation to acetyl-CoA http://purl.obolibrary.org/obo/GO_0019442 GO:0019440 biolink:BiologicalProcess tryptophan catabolic process to indole-3-acetate The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate. MetaCyc:TRPIAACAT-PWY go.json tryptophan breakdown to indole-3-acetate|tryptophan catabolic process to IAA|tryptophan catabolic process to indoleacetic acid|tryptophan catabolism to indoleacetic acid|tryptophan degradation to indole-3-acetate http://purl.obolibrary.org/obo/GO_0019440 GO:0044460 biolink:CellularComponent obsolete flagellum part OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium. go.json flagellum component|flagellum part True http://purl.obolibrary.org/obo/GO_0044460 GO:0044467 biolink:BiologicalProcess glial cell-derived neurotrophic factor production The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons. go.json GDNF production|glial cell line-derived neurotrophic factor production|glial cell-derived neurotrophic factor secretion http://purl.obolibrary.org/obo/GO_0044467 gocheck_do_not_annotate GO:0044468 biolink:BiologicalProcess envenomation resulting in modulation of blood coagulation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism. go.json envenomation resulting in modulation of blood coagulation in other organism|envenomation resulting in regulation of blood coagulation in other organism http://purl.obolibrary.org/obo/GO_0044468 GO:0044465 biolink:BiologicalProcess modulation of sensory perception of pain in another organism A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism. go.json modulation of sensory perception of pain in other organism|regulation of sensory perception of pain in another organism http://purl.obolibrary.org/obo/GO_0044465 GO:0044466 biolink:MolecularActivity glutaryl-CoA hydrolase activity Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate. EC:3.1.2.3 go.json glutaryl-CoA thioesterase activity http://purl.obolibrary.org/obo/GO_0044466 GO:0044463 biolink:CellularComponent obsolete cell projection part OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. go.json True http://purl.obolibrary.org/obo/GO_0044463 GO:0044464 biolink:CellularComponent obsolete cell part OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms. go.json cellular subcomponent|protoplast True http://purl.obolibrary.org/obo/GO_0044464 GO:0044461 biolink:CellularComponent obsolete bacterial-type flagellum part OBSOLETE. Any constituent part of the bacterial-type flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by a transmembrane ion potential, typically a proton or sodium potential. go.json flagellin-based flagellum part True http://purl.obolibrary.org/obo/GO_0044461 GO:0044462 biolink:CellularComponent obsolete external encapsulating structure part OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria). go.json True http://purl.obolibrary.org/obo/GO_0044462 GO:0019418 biolink:BiologicalProcess sulfide oxidation The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate. MetaCyc:P222-PWY go.json sulphide oxidation http://purl.obolibrary.org/obo/GO_0019418 GO:0019419 biolink:BiologicalProcess sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. go.json assimilatory sulfate reduction|assimilatory sulphate reduction|sulfate reduction, APS pathway|sulphate reduction|sulphate reduction, APS pathway http://purl.obolibrary.org/obo/GO_0019419 GO:0019416 biolink:BiologicalProcess polythionate oxidation The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor. MetaCyc:THIOSULFOX-PWY go.json http://purl.obolibrary.org/obo/GO_0019416 GO:0019417 biolink:BiologicalProcess sulfur oxidation The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur. go.json sulphur oxidation http://purl.obolibrary.org/obo/GO_0019417 GO:0044469 biolink:BiologicalProcess envenomation resulting in positive regulation of blood coagulation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism. go.json envenomation resulting in positive regulation of blood coagulation in other organism http://purl.obolibrary.org/obo/GO_0044469 GO:0019414 biolink:BiologicalProcess aerobic respiration, using sulfur or sulfate as electron donor An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized. go.json aerobic respiration, using sulphur or sulphate as electron donor http://purl.obolibrary.org/obo/GO_0019414 GO:0019415 biolink:BiologicalProcess acetate biosynthetic process from carbon monoxide The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide. go.json acetate anabolism from carbon monoxide|acetate formation from carbon monoxide|acetate synthesis from carbon monoxide|carbon monoxide dehydrogenase pathway http://purl.obolibrary.org/obo/GO_0019415 GO:0019412 biolink:BiologicalProcess aerobic respiration, using hydrogen as electron donor The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water. MetaCyc:P283-PWY go.json hydrogen oxidation http://purl.obolibrary.org/obo/GO_0019412 GO:0019413 biolink:BiologicalProcess acetate biosynthetic process The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. go.json acetate anabolism|acetate biosynthesis|acetate formation|acetate synthesis http://purl.obolibrary.org/obo/GO_0019413 GO:0019410 biolink:BiologicalProcess aerobic respiration, using carbon monoxide as electron donor The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation. go.json http://purl.obolibrary.org/obo/GO_0019410 GO:0019411 biolink:BiologicalProcess aerobic respiration, using ferrous ions as electron donor The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide. go.json http://purl.obolibrary.org/obo/GO_0019411 GO:0044470 biolink:BiologicalProcess envenomation resulting in negative regulation of blood coagulation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism. go.json envenomation resulting in negative regulation of blood coagulation in other organism http://purl.obolibrary.org/obo/GO_0044470 GO:0044471 biolink:BiologicalProcess envenomation resulting in pore formation in membrane of another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism. go.json envenomation resulting in pore formation in membrane of other organism http://purl.obolibrary.org/obo/GO_0044471 GO:0044478 biolink:BiologicalProcess envenomation resulting in positive regulation of platelet aggregation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism. go.json envenomation resulting in positive regulation of platelet aggregation in other organism http://purl.obolibrary.org/obo/GO_0044478 GO:0044479 biolink:BiologicalProcess envenomation resulting in modulation of mast cell degranulation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism. go.json envenomation resulting in modulation of mast cell degranulation in other organism http://purl.obolibrary.org/obo/GO_0044479 GO:0044476 biolink:BiologicalProcess envenomation resulting in negative regulation of low voltage-gated calcium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism. go.json envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044476 GO:0044477 biolink:BiologicalProcess envenomation resulting in negative regulation of platelet aggregation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism. go.json envenomation resulting in negative regulation of platelet aggregation in other organism http://purl.obolibrary.org/obo/GO_0044477 GO:0044474 biolink:BiologicalProcess envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism. go.json envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044474 GO:0044475 biolink:BiologicalProcess envenomation resulting in negative regulation of high voltage-gated calcium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism. go.json envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044475 GO:0044472 biolink:BiologicalProcess envenomation resulting in modulation of calcium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism. go.json envenomation resulting in modulation of calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044472 GO:0044473 biolink:BiologicalProcess envenomation resulting in negative regulation of calcium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism. go.json envenomation resulting in negative regulation of calcium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044473 GO:0019429 biolink:BiologicalProcess fluorene catabolic process The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents. MetaCyc:FLUORENE-DEG-9-ONE-PWY|UM-BBD_pathwayID:flu go.json fluorene breakdown|fluorene catabolism|fluorene degradation|fluorene metabolic process|fluorene metabolism http://purl.obolibrary.org/obo/GO_0019429 GO:0019427 biolink:BiologicalProcess acetyl-CoA biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate. MetaCyc:ACETATEUTIL-PWY go.json acetate utilization|acetyl-CoA anabolism from acetate|acetyl-CoA formation from acetate|acetyl-CoA synthesis from acetate http://purl.obolibrary.org/obo/GO_0019427 GO:0019428 biolink:BiologicalProcess allantoin biosynthetic process The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. MetaCyc:URSIN-PWY go.json allantoin anabolism|allantoin biosynthesis|allantoin formation|allantoin synthesis http://purl.obolibrary.org/obo/GO_0019428 GO:0019425 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019425 GO:0019426 biolink:BiologicalProcess bisulfite reduction The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite. MetaCyc:P224-PWY go.json bisulphite reduction http://purl.obolibrary.org/obo/GO_0019426 GO:0019423 biolink:BiologicalProcess sulfur oxidation, ferric ion-dependent A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+). MetaCyc:FESULFOX-PWY go.json sulphur oxidation, ferric ion-dependent http://purl.obolibrary.org/obo/GO_0019423 GO:0019424 biolink:BiologicalProcess sulfide oxidation, using siroheme sulfite reductase A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase. MetaCyc:P223-PWY go.json sulfide oxidation, using sirohaem sulfite reductase|sulfur oxidation, using sirohaem sulfite reductase|sulfur oxidation, using siroheme sulfite reductase|sulphide oxidation, using siroheme sulphite reductase|sulphur oxidation, using siroheme sulphite reductase http://purl.obolibrary.org/obo/GO_0019424 GO:0019421 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019421 GO:0019422 biolink:BiologicalProcess disproportionation of elemental sulfur The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2. MetaCyc:P203-PWY go.json disproportionation of elemental sulphur http://purl.obolibrary.org/obo/GO_0019422 GO:0019420 biolink:BiologicalProcess dissimilatory sulfate reduction The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide. MetaCyc:DISSULFRED-PWY go.json dissimilatory sulphate reduction http://purl.obolibrary.org/obo/GO_0019420 GO:0044481 biolink:BiologicalProcess obsolete envenomation resulting in proteolysis in another organism OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism. go.json envenomation resulting in proteolysis in other organism True http://purl.obolibrary.org/obo/GO_0044481 GO:0044482 biolink:BiologicalProcess envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism. go.json envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism|envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism http://purl.obolibrary.org/obo/GO_0044482 GO:0044480 biolink:BiologicalProcess envenomation resulting in positive regulation of mast cell degranulation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism. go.json envenomation resulting in positive regulation of mast cell degranulation in other organism http://purl.obolibrary.org/obo/GO_0044480 GO:0044489 biolink:BiologicalProcess negative regulation of voltage-gated sodium channel activity in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. go.json negative regulation of voltage-gated sodium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044489 gocheck_do_not_annotate GO:0044487 biolink:BiologicalProcess envenomation resulting in modulation of transmission of nerve impulse in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism. go.json envenomation resulting in modulation of conduction of nerve impulse in other organism|envenomation resulting in modulation of transmission of nerve impulse in other organism http://purl.obolibrary.org/obo/GO_0044487 GO:0044488 biolink:BiologicalProcess modulation of voltage-gated sodium channel activity in another organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. go.json modulation of voltage-gated sodium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044488 GO:0044485 biolink:BiologicalProcess envenomation resulting in fibrinogenolysis in another organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism. go.json envenomation resulting in fibrinogenolysis in other organism http://purl.obolibrary.org/obo/GO_0044485 GO:0044486 biolink:BiologicalProcess modulation of transmission of nerve impulse in another organism The process in which an organism effects a change in the transmission of a nerve impulse in another organism. go.json modulation of conduction of nerve impulse in other organism|modulation of transmission of nerve impulse in other organism|regulation of transmission of nerve impulse in other organism http://purl.obolibrary.org/obo/GO_0044486 GO:0044483 biolink:BiologicalProcess envenomation resulting in impairment of hemostasis in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism. go.json envenomation resulting in impairment of hemostasis in other organism|envenomation resulting in negative regulation of hemostasis in other organism|envenomation, impairing hemostasis in other organism http://purl.obolibrary.org/obo/GO_0044483 GO:0044484 biolink:BiologicalProcess envenomation resulting in fibrinolysis in another organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism. go.json envenomation resulting in fibrinolysis in other organism http://purl.obolibrary.org/obo/GO_0044484 GO:0044492 biolink:BiologicalProcess envenomation resulting in modulation of voltage-gated sodium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism. go.json envenomation resulting in modulation of voltage-gated sodium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044492 GO:0044493 biolink:BiologicalProcess envenomation resulting in negative regulation of voltage-gated sodium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism. go.json envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044493 GO:0044490 biolink:BiologicalProcess positive regulation of voltage-gated sodium channel activity in another organism Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. go.json positive regulation of voltage-gated sodium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044490 gocheck_do_not_annotate GO:0044491 biolink:BiologicalProcess positive regulation of molecular function in another organism Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism. go.json positive regulation of molecular function in other organism http://purl.obolibrary.org/obo/GO_0044491 gocheck_do_not_annotate GO:0044498 biolink:BiologicalProcess envenomation resulting in modulation of blood pressure in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism. go.json envenomation resulting in modulation of blood pressure in other organism|envenomation resulting in regulation of blood pressure in other organism http://purl.obolibrary.org/obo/GO_0044498 GO:0044499 biolink:BiologicalProcess envenomation resulting in positive regulation of blood pressure in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism. go.json envenomation resulting in positive regulation of blood pressure in other organism http://purl.obolibrary.org/obo/GO_0044499 GO:0044496 biolink:BiologicalProcess negative regulation of blood pressure in another organism A process by which one organism decreases the force with which blood travels through the circulatory system of another organism. go.json negative regulation of blood pressure in other organism http://purl.obolibrary.org/obo/GO_0044496 GO:0044497 biolink:BiologicalProcess positive regulation of blood pressure in another organism A process by which one organism increases the force with which blood travels through the circulatory system of another organism. go.json positive regulation of blood pressure in other organism http://purl.obolibrary.org/obo/GO_0044497 GO:0044494 biolink:BiologicalProcess envenomation resulting in positive regulation of voltage-gated sodium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism. go.json envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044494 GO:0044495 biolink:BiologicalProcess modulation of blood pressure in another organism A process by which one organism modulates the force with which blood travels through the circulatory system of another organism. go.json modulation of blood pressure in other organism|regulation of blood pressure in other organism http://purl.obolibrary.org/obo/GO_0044495 GO:0019409 biolink:BiologicalProcess aerobic respiration, using ammonia as electron donor The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite. MetaCyc:AMMOXID-PWY go.json aerobic ammonia oxidation to nitrite via hydrazine http://purl.obolibrary.org/obo/GO_0019409 GO:0019407 biolink:BiologicalProcess hexitol catabolic process The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule. go.json hexitol breakdown|hexitol catabolism|hexitol degradation http://purl.obolibrary.org/obo/GO_0019407 GO:0019408 biolink:BiologicalProcess dolichol biosynthetic process The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. go.json dolichol anabolism|dolichol biosynthesis|dolichol formation|dolichol synthesis http://purl.obolibrary.org/obo/GO_0019408 GO:0019405 biolink:BiologicalProcess alditol catabolic process The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. go.json alditol breakdown|alditol catabolism|alditol degradation http://purl.obolibrary.org/obo/GO_0019405 GO:0019406 biolink:BiologicalProcess hexitol biosynthetic process The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule. go.json hexitol anabolism|hexitol biosynthesis|hexitol formation|hexitol synthesis http://purl.obolibrary.org/obo/GO_0019406 GO:0019403 biolink:BiologicalProcess galactitol biosynthetic process The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. go.json galactitol anabolism|galactitol biosynthesis|galactitol formation|galactitol synthesis http://purl.obolibrary.org/obo/GO_0019403 GO:0019404 biolink:BiologicalProcess galactitol catabolic process The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. MetaCyc:GALACTITOLCAT-PWY go.json galactitol breakdown|galactitol catabolism|galactitol degradation http://purl.obolibrary.org/obo/GO_0019404 GO:0019401 biolink:BiologicalProcess alditol biosynthetic process The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. go.json alditol anabolism|alditol biosynthesis|alditol formation|alditol synthesis http://purl.obolibrary.org/obo/GO_0019401 GO:0019402 biolink:BiologicalProcess galactitol metabolic process The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. go.json galactitol metabolism http://purl.obolibrary.org/obo/GO_0019402 GO:0019400 biolink:BiologicalProcess alditol metabolic process The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. go.json alditol metabolism http://purl.obolibrary.org/obo/GO_0019400 GO:0019498 biolink:BiologicalProcess n-octane oxidation The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA. MetaCyc:P221-PWY go.json http://purl.obolibrary.org/obo/GO_0019498 GO:0019499 biolink:BiologicalProcess cyanide metabolic process The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain. go.json cyanide metabolism http://purl.obolibrary.org/obo/GO_0019499 GO:0019496 biolink:BiologicalProcess serine-isocitrate lyase pathway A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide. go.json http://purl.obolibrary.org/obo/GO_0019496 GO:0019497 biolink:BiologicalProcess hexachlorocyclohexane metabolic process The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution. go.json hexachlorocyclohexane metabolism http://purl.obolibrary.org/obo/GO_0019497 GO:0019494 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019494 GO:0019495 biolink:BiologicalProcess proline catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate. go.json proline breakdown to 2-oxoglutarate|proline catabolic process to 2-ketoglutarate|proline catabolic process to alpha-ketoglutarate|proline catabolic process to alpha-oxoglutarate|proline catabolism to 2-ketoglutarate|proline catabolism to alpha-ketoglutarate|proline catabolism to alpha-oxoglutarate|proline degradation to 2-oxoglutarate http://purl.obolibrary.org/obo/GO_0019495 GO:0019481 biolink:BiologicalProcess L-alanine catabolic process, by transamination The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination. MetaCyc:ALANINE-DEG3-PWY go.json L-alanine breakdown, by transamination|L-alanine degradation, by transamination http://purl.obolibrary.org/obo/GO_0019481 GO:0019482 biolink:BiologicalProcess beta-alanine metabolic process The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. Wikipedia:Beta-alanine go.json beta-alanine metabolism http://purl.obolibrary.org/obo/GO_0019482 GO:0019480 biolink:BiologicalProcess L-alanine oxidation to pyruvate via D-alanine The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate. MetaCyc:ALADEG-PWY go.json http://purl.obolibrary.org/obo/GO_0019480 GO:0044401 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044401 GO:0044402 biolink:BiologicalProcess obsolete competition with other organism OBSOLETE. Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community. go.json competition with another organism|interspecies competition True http://purl.obolibrary.org/obo/GO_0044402 GO:0044400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044400 GO:0044409 biolink:BiologicalProcess entry into host Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json entry into cell of other organism during symbiotic interaction|entry into cell of other organism involved in symbiotic interaction|entry into host cell|entry into host cell via penetration peg|entry into host through host barriers|entry into host via a specialized structure during symbiotic interaction|entry into host via enzymatic degradation of host anatomical structure|entry into host via enzymatic degradation of host cuticle|entry into other organism during symbiotic interaction|entry into other organism involved in symbiotic interaction|host cell invasion|host invasion|host penetration|invasion into host|invasion into other organism|invasion of host|invasion of other organism|invasive growth|other organism cell invasion|other organism invasion|penetration into host|penetration into host via a specialized structure|penetration into host via a specialized structure during symbiotic interaction http://purl.obolibrary.org/obo/GO_0044409 GO:0044407 biolink:BiologicalProcess single-species biofilm formation in or on host organism A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044407 GO:0044408 biolink:BiologicalProcess obsolete growth or development of symbiont on or near host OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. go.json growth or development of organism on or near host surface|growth or development of symbiont on or near host True http://purl.obolibrary.org/obo/GO_0044408 GO:0044405 biolink:BiologicalProcess obsolete detection of host OBSOLETE. The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json recognition of host True http://purl.obolibrary.org/obo/GO_0044405 GO:0044406 biolink:BiologicalProcess adhesion of symbiont to host The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion to host|adhesion to other organism during symbiotic interaction|adhesion to other organism involved in symbiotic interaction|host adhesion http://purl.obolibrary.org/obo/GO_0044406 GO:0044403 biolink:BiologicalProcess biological process involved in symbiotic interaction A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts. go.json commensalism|host-pathogen interaction|parasitism|symbiosis|symbiosis, encompassing mutualism through parasitism|symbiotic interaction|symbiotic interaction between host and organism|symbiotic interaction between organisms|symbiotic interaction between species|symbiotic process http://purl.obolibrary.org/obo/GO_0044403 goslim_chembl GO:0044404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044404 GO:0019478 biolink:BiologicalProcess D-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. go.json D-amino acid breakdown|D-amino acid catabolism|D-amino acid degradation http://purl.obolibrary.org/obo/GO_0019478 GO:0019479 biolink:BiologicalProcess L-alanine oxidation to D-lactate and ammonia The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia. MetaCyc:ALACAT2-PWY go.json http://purl.obolibrary.org/obo/GO_0019479 GO:0019476 biolink:BiologicalProcess D-lysine catabolic process The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid. go.json D-lysine breakdown|D-lysine catabolism|D-lysine degradation http://purl.obolibrary.org/obo/GO_0019476 GO:0019477 biolink:BiologicalProcess L-lysine catabolic process The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid. go.json L-lysine breakdown|L-lysine catabolism|L-lysine degradation http://purl.obolibrary.org/obo/GO_0019477 GO:0019474 biolink:BiologicalProcess L-lysine catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA. go.json L-lysine breakdown to acetyl-CoA|L-lysine degradation to acetyl-CoA http://purl.obolibrary.org/obo/GO_0019474 GO:0019475 biolink:BiologicalProcess L-lysine catabolic process to acetate The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate. MetaCyc:P163-PWY go.json L-lysine breakdown to acetate|L-lysine degradation to acetate|lysine fermentation http://purl.obolibrary.org/obo/GO_0019475 GO:0019472 biolink:BiologicalProcess 4-hydroxyproline biosynthetic process The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. go.json 4-hydroxyproline anabolism|4-hydroxyproline biosynthesis|4-hydroxyproline formation|4-hydroxyproline synthesis http://purl.obolibrary.org/obo/GO_0019472 GO:0019473 biolink:BiologicalProcess L-lysine catabolic process to glutarate, by acetylation The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation. MetaCyc:LYSDEGII-PWY go.json L-lysine breakdown to glutarate, by acetylation|L-lysine degradation to glutarate, by acetylation http://purl.obolibrary.org/obo/GO_0019473 GO:0019492 biolink:BiologicalProcess proline salvage Any process which produces the amino acid proline from derivatives of it, without de novo synthesis. go.json proline cycling http://purl.obolibrary.org/obo/GO_0019492 GO:0019493 biolink:BiologicalProcess arginine catabolic process to proline The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline. MetaCyc:ARG-PRO-PWY go.json arginine breakdown to proline|arginine degradation to proline http://purl.obolibrary.org/obo/GO_0019493 GO:0019490 biolink:BiologicalProcess 2-aminobenzenesulfonate desulfonation The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. MetaCyc:2ASDEG-PWY go.json 2-aminobenzenesulphonate desulphonation http://purl.obolibrary.org/obo/GO_0019490 GO:0019491 biolink:BiologicalProcess ectoine biosynthetic process The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. MetaCyc:P101-PWY go.json ectoine anabolism|ectoine biosynthesis|ectoine formation|ectoine synthesis http://purl.obolibrary.org/obo/GO_0019491 GO:0044412 biolink:BiologicalProcess obsolete growth or development of symbiont in host OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of organism within host|growth or development of symbiont in host|growth or development of symbiont within host|invasive growth True http://purl.obolibrary.org/obo/GO_0044412 GO:0044413 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044413 GO:0044410 biolink:BiologicalProcess obsolete entry into host through natural portals OBSOLETE. Penetration by a symbiont into a host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json entry into other organism through natural portals during symbiotic interaction|entry into other organism through natural portals involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0044410 GO:0044411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044411 GO:0044418 biolink:BiologicalProcess translocation of DNA into host The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json translocation of DNA into other organism during symbiotic interaction|translocation of DNA into other organism involved in symbiotic interaction|transport of DNA into host|transport of DNA into other organism during symbiotic interaction http://purl.obolibrary.org/obo/GO_0044418 GO:0044419 biolink:BiologicalProcess biological process involved in interspecies interaction between organisms Any process evolved to enable an interaction with an organism of a different species. go.json interaction with another species|interspecies interaction|interspecies interaction between organisms|interspecies interaction with other organisms http://purl.obolibrary.org/obo/GO_0044419 gocheck_do_not_annotate|goslim_candida|goslim_pir GO:0044416 biolink:BiologicalProcess induction by symbiont of host defense response The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host defense response|activation of host defense response|induction by organism of defense response of other organism involved in symbiotic interaction|positive regulation by organism of defense response of other organism involved in symbiotic interaction|positive regulation by symbiont of host defense response|stimulation by symbiont of host defense response|up regulation by symbiont of host defense response|up-regulation by symbiont of host defense response|upregulation by symbiont of host defense response http://purl.obolibrary.org/obo/GO_0044416 GO:0044417 biolink:BiologicalProcess translocation of molecules into host The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json translocation of molecules into other organism during symbiotic interaction|translocation of molecules into other organism involved in symbiotic interaction|transport of molecules into host|transport of molecules into other organism during symbiotic interaction http://purl.obolibrary.org/obo/GO_0044417 GO:0044414 biolink:BiologicalProcess suppression of host defenses by symbiont Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by organism of defense response of other organism during symbiotic interaction|down regulation by symbiont of host defense response|down-regulation by organism of defense response of other organism during symbiotic interaction|down-regulation by symbiont of host defense response|downregulation by organism of defense response of other organism during symbiotic interaction|downregulation by symbiont of host defense response|inhibition by organism of defense response of other organism during symbiotic interaction|inhibition by symbiont of host defense response|negative regulation by organism of defense response of other organism during symbiotic interaction|negative regulation by organism of defense response of other organism involved in symbiotic interaction|negative regulation by symbiont of host defense response|negative regulation of host defenses|suppression of defense response of other organism|suppression of defense response of other organism involved in symbiotic interaction|suppression of defenses of other organism involved in symbiotic interaction|suppression of host defense response http://purl.obolibrary.org/obo/GO_0044414 GO:0044415 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044415 GO:0019489 biolink:BiologicalProcess methylgallate metabolic process The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. go.json methylgallate metabolism http://purl.obolibrary.org/obo/GO_0019489 GO:0019487 biolink:BiologicalProcess anaerobic acetylene catabolic process The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen. MetaCyc:P161-PWY go.json anaerobic acetylene breakdown|anaerobic acetylene catabolism|anaerobic acetylene degradation|anaerobic ethyne catabolic process|anaerobic ethyne catabolism http://purl.obolibrary.org/obo/GO_0019487 GO:0019488 biolink:BiologicalProcess ribitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate. MetaCyc:RIBITOLUTIL-PWY go.json ribitol breakdown to xylulose 5-phosphate|ribitol degradation to xylulose 5-phosphate|ribitol utilization http://purl.obolibrary.org/obo/GO_0019488 GO:0019485 biolink:BiologicalProcess beta-alanine catabolic process to L-alanine The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine. go.json beta-alanine breakdown to L-alanine|beta-alanine degradation to L-alanine http://purl.obolibrary.org/obo/GO_0019485 GO:0019486 biolink:BiologicalProcess beta-alanine catabolic process to mevalonate semialdehyde, by transamination The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination. MetaCyc:BETA-ALA-DEGRADATION-I-PWY go.json beta-alanine breakdown to mevalonate semialdehyde, by transamination|beta-alanine degradation to mevalonate semialdehyde, by transamination http://purl.obolibrary.org/obo/GO_0019486 GO:0019483 biolink:BiologicalProcess beta-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. go.json beta-alanine anabolism|beta-alanine biosynthesis|beta-alanine formation|beta-alanine synthesis http://purl.obolibrary.org/obo/GO_0019483 GO:0019484 biolink:BiologicalProcess beta-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. go.json beta-alanine breakdown|beta-alanine catabolism|beta-alanine degradation http://purl.obolibrary.org/obo/GO_0019484 GO:0044382 biolink:BiologicalProcess CLRC complex localization to heterochromatin The process by which a CLRC complex is transported to, or maintained in, heterochromatin. CLRC complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation. go.json CLRC ubiquitin ligase complex localisation to heterochromatin|CLRC ubiquitin ligase complex localization to heterochromatin http://purl.obolibrary.org/obo/GO_0044382 GO:0044383 biolink:CellularComponent host chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell. go.json http://purl.obolibrary.org/obo/GO_0044383 GO:0044380 biolink:BiologicalProcess protein localization to cytoskeleton A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. go.json protein localisation to cytoskeleton http://purl.obolibrary.org/obo/GO_0044380 GO:0044381 biolink:BiologicalProcess glucose import in response to insulin stimulus The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus. go.json cellular glucose import in response to insulin stimulus http://purl.obolibrary.org/obo/GO_0044381 GO:0044388 biolink:MolecularActivity small protein activating enzyme binding Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. go.json http://purl.obolibrary.org/obo/GO_0044388 GO:0044389 biolink:MolecularActivity ubiquitin-like protein ligase binding Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. go.json E3 protein ligase binding|small conjugating protein ligase binding http://purl.obolibrary.org/obo/GO_0044389 GO:0044386 biolink:CellularComponent obsolete integral to host endoplasmic reticulum membrane OBSOLETE. Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell. go.json True http://purl.obolibrary.org/obo/GO_0044386 GO:0044387 biolink:BiologicalProcess negative regulation of protein kinase activity by regulation of protein phosphorylation The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase. go.json http://purl.obolibrary.org/obo/GO_0044387 gocheck_do_not_annotate GO:0044384 biolink:CellularComponent host outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. go.json host cell outer membrane http://purl.obolibrary.org/obo/GO_0044384 GO:0044385 biolink:CellularComponent obsolete integral to membrane of host cell OBSOLETE. Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell. go.json True http://purl.obolibrary.org/obo/GO_0044385 GO:0044393 biolink:CellularComponent microspike A dynamic, actin-rich projection extending from the surface of a migrating animal cell. go.json http://purl.obolibrary.org/obo/GO_0044393 GO:0044394 biolink:BiologicalProcess protein malonylation The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group. go.json http://purl.obolibrary.org/obo/GO_0044394 gocheck_do_not_annotate GO:0044391 biolink:CellularComponent ribosomal subunit Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. go.json http://purl.obolibrary.org/obo/GO_0044391 GO:0044392 biolink:BiologicalProcess peptidyl-lysine malonylation The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine. RESID:AA0568 go.json lysine malonylation http://purl.obolibrary.org/obo/GO_0044392 gocheck_do_not_annotate GO:0044390 biolink:MolecularActivity ubiquitin-like protein conjugating enzyme binding Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. go.json E2 protein ligase binding|small protein conjugating enzyme binding http://purl.obolibrary.org/obo/GO_0044390 GO:0044399 biolink:BiologicalProcess multi-species biofilm formation A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. go.json multi-species biofilm formation in or on host organism|multi-species biofilm formation on inanimate substrate|multi-species submerged biofilm formation|multi-species surface biofilm formation http://purl.obolibrary.org/obo/GO_0044399 GO:0044397 biolink:BiologicalProcess obsolete actin cortical patch internalization OBSOLETE. A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell. go.json True http://purl.obolibrary.org/obo/GO_0044397 GO:0044398 biolink:BiologicalProcess envenomation resulting in induction of edema in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation. go.json envenomation resulting in induction of edema in other organism|envenomation resulting in induction of oedema in other organism http://purl.obolibrary.org/obo/GO_0044398 GO:0044395 biolink:BiologicalProcess protein targeting to vacuolar membrane The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein. go.json http://purl.obolibrary.org/obo/GO_0044395 GO:0044396 biolink:BiologicalProcess actin cortical patch organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis. go.json actin cortical patch organisation http://purl.obolibrary.org/obo/GO_0044396 GO:0019580 biolink:BiologicalProcess galactarate metabolic process The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose. go.json D-galactarate metabolic process|D-galactarate metabolism|galactarate metabolism|mucic acid metabolic process|mucic acid metabolism http://purl.obolibrary.org/obo/GO_0019580 GO:0019581 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019581 GO:0044544 biolink:BiologicalProcess envenomation resulting in plasminogen activation in another organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. go.json envenomation resulting in plasminogen activation in other organism http://purl.obolibrary.org/obo/GO_0044544 GO:0044545 biolink:CellularComponent NSL complex A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1. go.json non-specific lethal complex http://purl.obolibrary.org/obo/GO_0044545 GO:0044542 biolink:BiologicalProcess plasminogen activation in another organism The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism. go.json plasminogen activation in other organism http://purl.obolibrary.org/obo/GO_0044542 GO:0044543 biolink:BiologicalProcess obsolete envenomation resulting in zymogen activation in another organism OBSOLETE. The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form. go.json envenomation resulting in zymogen activation in other organism True http://purl.obolibrary.org/obo/GO_0044543 GO:0044540 biolink:MolecularActivity L-cystine L-cysteine-lyase (deaminating) Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. EC:4.4.1.1|KEGG_REACTION:R02408|RHEA:24927 go.json http://purl.obolibrary.org/obo/GO_0044540 GO:0044541 biolink:BiologicalProcess zymogen activation in another organism The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism. go.json zymogen activation in other organism http://purl.obolibrary.org/obo/GO_0044541 GO:0044548 biolink:MolecularActivity S100 protein binding Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. go.json S100 alpha binding|S100 beta binding|S100 binding http://purl.obolibrary.org/obo/GO_0044548 GO:0044549 biolink:MolecularActivity GTP cyclohydrolase binding Binding to a GTP cyclohydrolase. go.json GTP cyclohydrolase I binding http://purl.obolibrary.org/obo/GO_0044549 GO:0044546 biolink:BiologicalProcess NLRP3 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell. go.json NALP3 inflammasome complex assembly|NLRP3 inflammasome activation http://purl.obolibrary.org/obo/GO_0044546 GO:0019579 biolink:BiologicalProcess aldaric acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. go.json aldaric acid breakdown|aldaric acid catabolism|aldaric acid degradation http://purl.obolibrary.org/obo/GO_0019579 GO:0044547 biolink:MolecularActivity DNA topoisomerase binding Binding to a DNA topoisomerase. go.json DNA topoisomerase I binding http://purl.obolibrary.org/obo/GO_0044547 GO:0019577 biolink:BiologicalProcess aldaric acid metabolic process The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. go.json aldaric acid metabolism http://purl.obolibrary.org/obo/GO_0019577 GO:0019578 biolink:BiologicalProcess aldaric acid biosynthetic process The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. go.json aldaric acid anabolism|aldaric acid biosynthesis|aldaric acid formation|aldaric acid synthesis http://purl.obolibrary.org/obo/GO_0019578 GO:0019575 biolink:BiologicalProcess obsolete sucrose catabolic process, using beta-fructofuranosidase OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26). MetaCyc:SUCUTIL-PWY go.json sucrose breakdown, using beta-fructofuranosidase|sucrose catabolic process, using beta-fructofuranosidase|sucrose catabolism, using beta-fructofuranosidase|sucrose degradation, using beta-fructofuranosidase True http://purl.obolibrary.org/obo/GO_0019575 GO:0019576 biolink:BiologicalProcess aerobic fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen. go.json aerobic fructose breakdown|aerobic fructose catabolism|aerobic fructose degradation http://purl.obolibrary.org/obo/GO_0019576 GO:0019573 biolink:BiologicalProcess D-arabinose catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate. MetaCyc:DARABCAT-PWY go.json D-arabinose breakdown to xylulose 5-phosphate|D-arabinose degradation to xylulose 5-phosphate http://purl.obolibrary.org/obo/GO_0019573 GO:0019574 biolink:BiologicalProcess sucrose catabolic process via 3'-ketosucrose The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose. MetaCyc:SUCROSEUTIL2-PWY go.json sucrose breakdown, using glucoside 3-dehydrogenase|sucrose catabolic process to D-glucose|sucrose catabolic process, using glucoside 3-dehydrogenase|sucrose catabolism, using glucoside 3-dehydrogenase|sucrose degradation, using glucoside 3-dehydrogenase http://purl.obolibrary.org/obo/GO_0019574 GO:0019571 biolink:BiologicalProcess D-arabinose catabolic process The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose. go.json D-arabinose breakdown|D-arabinose catabolism|D-arabinose degradation http://purl.obolibrary.org/obo/GO_0019571 GO:0019572 biolink:BiologicalProcess L-arabinose catabolic process The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose. go.json L-arabinose breakdown|L-arabinose catabolism|L-arabinose degradation http://purl.obolibrary.org/obo/GO_0019572 GO:0019591 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019591 GO:0019592 biolink:BiologicalProcess mannitol catabolic process The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. MetaCyc:MANNIDEG-PWY|MetaCyc:PWY-3861 go.json mannitol breakdown|mannitol catabolism|mannitol degradation http://purl.obolibrary.org/obo/GO_0019592 GO:0019590 biolink:BiologicalProcess L-arabitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. MetaCyc:LARABITOLUTIL-PWY go.json L-arabitol and xylitol degradation|L-arabitol breakdown to xylulose 5-phosphate|L-arabitol degradation to xylulose 5-phosphate|L-arabitol utilization http://purl.obolibrary.org/obo/GO_0019590 GO:0044555 biolink:BiologicalProcess negative regulation of heart rate in another organism Any process that stops, prevents or reduces the frequency of heart contraction of another organism. go.json negative regulation of heart rate in other organism http://purl.obolibrary.org/obo/GO_0044555 GO:0044556 biolink:BiologicalProcess envenomation resulting in negative regulation of heart rate in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism. go.json envenomation resulting in negative regulation of heart rate of other organism http://purl.obolibrary.org/obo/GO_0044556 GO:0044553 biolink:BiologicalProcess modulation of biological quality in another organism Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. go.json modulation of biological quality in other organism|regulation of biological quality in other organism http://purl.obolibrary.org/obo/GO_0044553 GO:0044554 biolink:BiologicalProcess modulation of heart rate in another organism Any process that modulates the frequency or rate of heart contraction of another organism. go.json modulation of heart rate in other organism|regulation of heart rate in other organism http://purl.obolibrary.org/obo/GO_0044554 GO:0044551 biolink:BiologicalProcess envenomation resulting in vasodilation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism. go.json envenomation resulting in modulation of vasodilation in other organism|envenomation resulting in regulation of vasodilation in other organism|envenomation resulting in vasodilation in other organism http://purl.obolibrary.org/obo/GO_0044551 GO:0044552 biolink:BiologicalProcess vasodilation in another organism A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism. go.json modulation of vasodilation in other organism|regulation of vasodilation in other organism|vasodilation in other organism http://purl.obolibrary.org/obo/GO_0044552 GO:0044550 biolink:BiologicalProcess secondary metabolite biosynthetic process The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. go.json secondary metabolite biosynthesis http://purl.obolibrary.org/obo/GO_0044550 prokaryote_subset GO:0044559 biolink:BiologicalProcess envenomation resulting in modulation of voltage-gated potassium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism. go.json envenomation resulting in modulation of voltage-gated potassium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044559 GO:0044557 biolink:BiologicalProcess relaxation of smooth muscle A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. go.json smooth muscle relaxation http://purl.obolibrary.org/obo/GO_0044557 GO:0044558 biolink:BiologicalProcess uterine smooth muscle relaxation A process in which the extent of smooth muscle contraction is reduced in the uterus. go.json smooth muscle relaxation of the uterus http://purl.obolibrary.org/obo/GO_0044558 GO:0019588 biolink:BiologicalProcess anaerobic glycerol catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP. go.json glycerol fermentation http://purl.obolibrary.org/obo/GO_0019588 GO:0019589 biolink:BiologicalProcess anaerobic glycerol catabolic process to propane-1,3-diol The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water. MetaCyc:GOLPDLCAT-PWY go.json glycerol fermentation to 1,3-propanediol|glycerol fermentation to propane-1,3-diol http://purl.obolibrary.org/obo/GO_0019589 GO:0019586 biolink:BiologicalProcess galacturonate metabolic process The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. go.json galacturonate metabolism http://purl.obolibrary.org/obo/GO_0019586 GO:0019587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019587 GO:0019584 biolink:BiologicalProcess galactonate catabolic process The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid. MetaCyc:GALACTCAT-PWY go.json galactonate breakdown|galactonate catabolism|galactonate degradation http://purl.obolibrary.org/obo/GO_0019584 GO:0019585 biolink:BiologicalProcess glucuronate metabolic process The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. Wikipedia:Glucuronic_acid go.json glucuronate metabolism http://purl.obolibrary.org/obo/GO_0019585 GO:0019582 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019582 GO:0019583 biolink:BiologicalProcess galactonate metabolic process The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose. go.json galactonate metabolism http://purl.obolibrary.org/obo/GO_0019583 GO:0044566 biolink:BiologicalProcess chondrocyte activation A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. go.json http://purl.obolibrary.org/obo/GO_0044566 GO:0044567 biolink:CellularComponent primary cell wall cellulose synthase complex A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein. go.json primary cell wall CESA complex|primary cell-wall cellulose synthase complex http://purl.obolibrary.org/obo/GO_0044567 GO:0044564 biolink:BiologicalProcess envenomation resulting in occlusion of the pore of voltage-gated potassium channel in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism. go.json envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism http://purl.obolibrary.org/obo/GO_0044564 GO:0044565 biolink:BiologicalProcess dendritic cell proliferation The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. go.json http://purl.obolibrary.org/obo/GO_0044565 GO:0044562 biolink:BiologicalProcess envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism. go.json envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044562 GO:0044563 biolink:BiologicalProcess envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism. go.json envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism|voltage-dependence of activation shift (to the left) http://purl.obolibrary.org/obo/GO_0044563 GO:0044560 biolink:BiologicalProcess envenomation resulting in modulation of ion channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism. go.json envenomation resulting in modulation of ion channel activity in other organism|envenomation resulting in regulation of ion channel activity in other organism http://purl.obolibrary.org/obo/GO_0044560 GO:0044561 biolink:BiologicalProcess modulation of ion channel activity in another organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism. go.json modulation of ion channel activity in other organism|regulation of ion channel activity in other organism http://purl.obolibrary.org/obo/GO_0044561 GO:0019559 biolink:BiologicalProcess histidine catabolic process to imidazol-5-yl-lactate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate. MetaCyc:HISTDEG-PWY go.json histidine breakdown to imidazol-5-yl-lactate|histidine degradation to imidazol-5-yl-lactate http://purl.obolibrary.org/obo/GO_0019559 GO:0044568 biolink:CellularComponent secondary cell wall cellulose synthase complex A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4. go.json secondary cell wall CESA complex|secondary cell-wall cellulose synthase complex http://purl.obolibrary.org/obo/GO_0044568 GO:0019557 biolink:BiologicalProcess histidine catabolic process to glutamate and formate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate. go.json histidine breakdown to glutamate and formate|histidine degradation to glutamate and formate http://purl.obolibrary.org/obo/GO_0019557 GO:0044569 biolink:CellularComponent [Ni-Fe] hydrogenase complex A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer. go.json Ni-Fe hydrogenase complex|nickel-iron hydrogenase complex http://purl.obolibrary.org/obo/GO_0044569 GO:0019558 biolink:BiologicalProcess histidine catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate. go.json histidine breakdown to 2-oxoglutarate|histidine catabolic process to 2-ketoglutarate|histidine catabolic process to alpha-ketoglutarate|histidine catabolic process to alpha-oxoglutarate|histidine catabolism to 2-ketoglutarate|histidine catabolism to alpha-ketoglutarate|histidine catabolism to alpha-oxoglutarate|histidine degradation to 2-oxoglutarate http://purl.obolibrary.org/obo/GO_0019558 GO:0019555 biolink:BiologicalProcess glutamate catabolic process to ornithine The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine. MetaCyc:GLUTORN-PWY go.json glutamate breakdown to ornithine|glutamate degradation to ornithine http://purl.obolibrary.org/obo/GO_0019555 GO:0019556 biolink:BiologicalProcess histidine catabolic process to glutamate and formamide The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide. MetaCyc:HISDEG-PWY go.json histidine breakdown to glutamate and formamide|histidine degradation to glutamate and formamide http://purl.obolibrary.org/obo/GO_0019556 GO:0019553 biolink:BiologicalProcess glutamate catabolic process via L-citramalate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate. MetaCyc:GLUDEG-II-PWY go.json glutamate breakdown via L-citramalate|glutamate degradation via L-citramalate http://purl.obolibrary.org/obo/GO_0019553 GO:0019554 biolink:BiologicalProcess glutamate catabolic process to oxaloacetate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate. go.json glutamate breakdown to oxaloacetate|glutamate degradation to oxaloacetate http://purl.obolibrary.org/obo/GO_0019554 GO:0019551 biolink:BiologicalProcess glutamate catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate. MetaCyc:GLUTAMATE-DEG1-PWY|MetaCyc:PWY-5766 go.json glutamate breakdown to 2-oxoglutarate|glutamate catabolic process to 2-ketoglutarate|glutamate catabolic process to alpha-ketoglutarate|glutamate catabolic process to alpha-oxoglutarate|glutamate catabolism to 2-ketoglutarate|glutamate catabolism to alpha-ketoglutarate|glutamate catabolism to alpha-oxoglutarate|glutamate degradation to 2-oxoglutarate http://purl.obolibrary.org/obo/GO_0019551 GO:0019552 biolink:BiologicalProcess glutamate catabolic process via 2-hydroxyglutarate The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP. MetaCyc:P162-PWY go.json glutamate fermentation via 2-hydroxyglutarate http://purl.obolibrary.org/obo/GO_0019552 GO:0019550 biolink:BiologicalProcess glutamate catabolic process to aspartate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate. MetaCyc:GLUTDEG-PWY go.json glutamate breakdown to aspartate|glutamate degradation to aspartate http://purl.obolibrary.org/obo/GO_0019550 GO:0044570 biolink:CellularComponent starch utilization system complex A bacterial cell envelope-associated multiprotein system, which binds and degrades starch. go.json Sus complex http://purl.obolibrary.org/obo/GO_0044570 GO:0019570 biolink:BiologicalProcess L-arabinose catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate. go.json L-arabinose breakdown to 2-oxoglutarate|L-arabinose catabolic process to 2-ketoglutarate|L-arabinose catabolic process to alpha-ketoglutarate|L-arabinose catabolic process to alpha-oxoglutarate|L-arabinose catabolism to 2-ketoglutarate|L-arabinose catabolism to alpha-ketoglutarate|L-arabinose catabolism to alpha-oxoglutarate|L-arabinose degradation to 2-oxoglutarate http://purl.obolibrary.org/obo/GO_0019570 GO:0044577 biolink:BiologicalProcess xylose catabolic process to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol. go.json xylose catabolism to ethanol http://purl.obolibrary.org/obo/GO_0044577 GO:0044578 biolink:BiologicalProcess butyryl-CoA biosynthetic process The chemical reactions and pathway resulting in the formation of butyryl-CoA. go.json butyryl-CoA biosynthesis http://purl.obolibrary.org/obo/GO_0044578 GO:0044575 biolink:BiologicalProcess cellulosome assembly The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall. go.json http://purl.obolibrary.org/obo/GO_0044575 GO:0044576 biolink:BiologicalProcess pentose catabolic process to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol. go.json pentose catabolism to ethanol http://purl.obolibrary.org/obo/GO_0044576 GO:0044573 biolink:BiologicalProcess nitrogenase P cluster assembly The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide. go.json nitrogenase P cluster biosynthesis|nitrogenase P cluster maturation http://purl.obolibrary.org/obo/GO_0044573 GO:0044574 biolink:BiologicalProcess starch utilization system complex assembly The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan. go.json SUS complex assembly|assembly of starch utilization system complex http://purl.obolibrary.org/obo/GO_0044574 GO:0044571 biolink:BiologicalProcess [2Fe-2S] cluster assembly The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. go.json 2Fe-2S cluster assembly|[2Fe-2S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_0044571 GO:0044572 biolink:BiologicalProcess [4Fe-4S] cluster assembly The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster. go.json 4Fe-4S cluster assembly|[4Fe-4S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_0044572 GO:0019568 biolink:BiologicalProcess arabinose catabolic process The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose. go.json arabinose breakdown|arabinose catabolism|arabinose degradation http://purl.obolibrary.org/obo/GO_0019568 GO:0044579 biolink:BiologicalProcess butyryl-CoA biosynthetic process from acetyl-CoA The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA. go.json butyryl-CoA biosynthesis from acetyl-CoA http://purl.obolibrary.org/obo/GO_0044579 GO:0019569 biolink:BiologicalProcess L-arabinose catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate. MetaCyc:ARABCAT-PWY go.json L-arabinose breakdown to xylulose 5-phosphate|L-arabinose degradation to xylulose 5-phosphate http://purl.obolibrary.org/obo/GO_0019569 GO:0019566 biolink:BiologicalProcess arabinose metabolic process The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides. go.json arabinose metabolism http://purl.obolibrary.org/obo/GO_0019566 GO:0019567 biolink:BiologicalProcess arabinose biosynthetic process The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose. go.json arabinose anabolism|arabinose biosynthesis|arabinose formation|arabinose synthesis http://purl.obolibrary.org/obo/GO_0019567 GO:0019564 biolink:BiologicalProcess aerobic glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen. MetaCyc:PWY0-381 go.json aerobic glycerol breakdown|aerobic glycerol catabolism|aerobic glycerol degradation|aerobic glycerol fermentation http://purl.obolibrary.org/obo/GO_0019564 GO:0019565 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019565 GO:0019562 biolink:BiologicalProcess obsolete L-phenylalanine catabolic process to phosphoenolpyruvate OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate. MetaCyc:PHENYLALANINE-DEG1-PWY go.json phenylalanine breakdown to phosphoenolpyruvate|phenylalanine degradation to phosphoenolpyruvate True http://purl.obolibrary.org/obo/GO_0019562 GO:0019563 biolink:BiologicalProcess glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. MetaCyc:PWY-4261|MetaCyc:PWY0-381 go.json glycerol breakdown|glycerol catabolism|glycerol degradation http://purl.obolibrary.org/obo/GO_0019563 GO:0019560 biolink:BiologicalProcess histidine catabolic process to hydantoin-5-propionate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate. MetaCyc:HISHP-PWY go.json histidine breakdown to hydantoin-5-propionate|histidine degradation to hydantoin-5-propionate http://purl.obolibrary.org/obo/GO_0019560 GO:0019561 biolink:BiologicalProcess anaerobic phenylalanine oxidation The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde. MetaCyc:ANAPHENOXI-PWY go.json http://purl.obolibrary.org/obo/GO_0019561 GO:0044580 biolink:BiologicalProcess butyryl-CoA catabolic process The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA. go.json butyryl-CoA catabolism http://purl.obolibrary.org/obo/GO_0044580 GO:0044581 biolink:BiologicalProcess butyryl-CoA catabolic process to butyrate The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate. go.json butyryl-CoA catabolism to butyrate http://purl.obolibrary.org/obo/GO_0044581 GO:0044588 biolink:MolecularActivity laminaribiose binding Binding to laminaribiose, a disaccharide. go.json http://purl.obolibrary.org/obo/GO_0044588 GO:0044589 biolink:MolecularActivity pectin binding Binding to pectin. go.json http://purl.obolibrary.org/obo/GO_0044589 GO:0044586 biolink:MolecularActivity cellotetraose binding Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose. go.json http://purl.obolibrary.org/obo/GO_0044586 GO:0044587 biolink:MolecularActivity cellopentaose binding Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose. go.json http://purl.obolibrary.org/obo/GO_0044587 GO:0044584 biolink:MolecularActivity cellodextrin binding Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers. go.json http://purl.obolibrary.org/obo/GO_0044584 GO:0044585 biolink:MolecularActivity cellobiose binding Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose. go.json http://purl.obolibrary.org/obo/GO_0044585 GO:0044582 biolink:BiologicalProcess butyryl-CoA catabolic process to butanol The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol. go.json butyryl-CoA catabolism to butanol http://purl.obolibrary.org/obo/GO_0044582 GO:0044583 biolink:MolecularActivity cellotriose binding Binding to cellotriose. go.json http://purl.obolibrary.org/obo/GO_0044583 GO:0019539 biolink:BiologicalProcess hydroxymate-containing siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid. Hydroxamate is one of the three major chemical groups incorporated into siderophore structures with catechol and a-hydroxycarboxylate, each having a high selectivity for iron(3+). go.json http://purl.obolibrary.org/obo/GO_0019539 GO:0019537 biolink:BiologicalProcess vibriobactin biosynthetic process The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae. go.json vibriobactin anabolism|vibriobactin biosynthesis|vibriobactin biosynthetic process, peptide formation|vibriobactin biosynthetic process, peptide modification|vibriobactin formation|vibriobactin synthesis http://purl.obolibrary.org/obo/GO_0019537 GO:0019538 biolink:BiologicalProcess protein metabolic process The chemical reactions and pathways involving a protein. Includes protein modification. Wikipedia:Protein_metabolism go.json cellular protein metabolic process|cellular protein metabolism|multicellular organismal protein metabolic process|protein metabolic process and modification|protein metabolism|protein metabolism and modification http://purl.obolibrary.org/obo/GO_0019538 goslim_agr|goslim_flybase_ribbon|goslim_mouse|goslim_pir|goslim_plant GO:0019535 biolink:MolecularActivity ferric-vibriobactin transmembrane transporter activity Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0019535 GO:0019536 biolink:BiologicalProcess vibriobactin metabolic process The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae. go.json vibriobactin metabolism http://purl.obolibrary.org/obo/GO_0019536 GO:0019533 biolink:BiologicalProcess cellobiose transport The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. go.json http://purl.obolibrary.org/obo/GO_0019533 GO:0019534 biolink:MolecularActivity toxin transmembrane transporter activity Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. go.json http://purl.obolibrary.org/obo/GO_0019534 GO:0019531 biolink:MolecularActivity oxalate transmembrane transporter activity Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. go.json oxalic acid transporter activity http://purl.obolibrary.org/obo/GO_0019531 GO:0019532 biolink:BiologicalProcess oxalate transport The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. go.json ethanedioate transport|ethanedioic acid transport|oxalic acid transport http://purl.obolibrary.org/obo/GO_0019532 GO:0019530 biolink:BiologicalProcess taurine metabolic process The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. go.json taurine metabolism http://purl.obolibrary.org/obo/GO_0019530 GO:0044591 biolink:BiologicalProcess response to amylopectin A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus. go.json http://purl.obolibrary.org/obo/GO_0044591 GO:0044592 biolink:BiologicalProcess response to pullulan A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus. go.json http://purl.obolibrary.org/obo/GO_0044592 GO:0044590 biolink:MolecularActivity iron-sulfur-molybdenum cofactor binding Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase. go.json FeMo co binding|FeMoco binding http://purl.obolibrary.org/obo/GO_0044590 GO:0044599 biolink:CellularComponent AP-5 adaptor complex An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo. go.json adaptor protein-5 adaptor complex http://purl.obolibrary.org/obo/GO_0044599 GO:0044597 biolink:BiologicalProcess daunorubicin metabolic process The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. go.json http://purl.obolibrary.org/obo/GO_0044597 GO:0044598 biolink:BiologicalProcess doxorubicin metabolic process The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. go.json http://purl.obolibrary.org/obo/GO_0044598 GO:0044595 biolink:MolecularActivity decaprenyldihydroxybenzoate methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate. MetaCyc:RXN-9282|RHEA:44492|Reactome:R-HSA-2162193 go.json http://purl.obolibrary.org/obo/GO_0044595 GO:0044596 biolink:MolecularActivity 3-demethylubiquinol-10 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10. MetaCyc:RXN-9237|RHEA:44412|Reactome:R-HSA-2162186 go.json http://purl.obolibrary.org/obo/GO_0044596 GO:0044593 biolink:BiologicalProcess iron-sulfur-molybdenum cofactor assembly The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase. go.json FeMoco assembly|FeMoco biosynthetic process|iron molybdenum cofactor assembly|iron molybdenum cofactor biosynthesis|iron molybdenum cofactor biosynthetic process http://purl.obolibrary.org/obo/GO_0044593 GO:0044594 biolink:MolecularActivity 17-beta-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. go.json http://purl.obolibrary.org/obo/GO_0044594 GO:0019548 biolink:BiologicalProcess arginine catabolic process to spermine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine. MetaCyc:ARGSPECAT-PWY go.json arginine breakdown to spermine|arginine degradation to spermine http://purl.obolibrary.org/obo/GO_0019548 GO:0019549 biolink:BiologicalProcess glutamate catabolic process to succinate via succinate semialdehyde The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase. go.json glutamate breakdown to succinate|glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity|glutamate degradation to succinate http://purl.obolibrary.org/obo/GO_0019549 GO:0019546 biolink:BiologicalProcess arginine deiminase pathway The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase. MetaCyc:ARGDEGRAD-PWY go.json http://purl.obolibrary.org/obo/GO_0019546 GO:0019547 biolink:BiologicalProcess arginine catabolic process to ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine. go.json arginine breakdown to ornithine|arginine degradation to ornithine http://purl.obolibrary.org/obo/GO_0019547 GO:0019544 biolink:BiologicalProcess arginine catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate. MetaCyc:ARG-GLU-PWY|MetaCyc:ARGASEDEG-PWY go.json arginine breakdown to glutamate|arginine degradation to glutamate http://purl.obolibrary.org/obo/GO_0019544 GO:0019545 biolink:BiologicalProcess arginine catabolic process to succinate The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate. MetaCyc:ARGDEG-III-PWY|MetaCyc:ARGDEG-IV-PWY|MetaCyc:ARGDEG-V-PWY|MetaCyc:AST-PWY go.json arginine breakdown to succinate|arginine degradation to succinate http://purl.obolibrary.org/obo/GO_0019545 GO:0019542 biolink:BiologicalProcess propionate biosynthetic process The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid. go.json propionate anabolism|propionate biosynthesis|propionate formation|propionate synthesis http://purl.obolibrary.org/obo/GO_0019542 GO:0019543 biolink:BiologicalProcess propionate catabolic process The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid. go.json propionate breakdown|propionate catabolism|propionate degradation http://purl.obolibrary.org/obo/GO_0019543 GO:0019540 biolink:BiologicalProcess catechol-containing siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol. Catechol is one of the three major chemical groups incorporated into siderophore structures with hydroxamate and a-hydroxycarboxylate, each having a high selectivity for iron(3+). go.json http://purl.obolibrary.org/obo/GO_0019540 GO:0019541 biolink:BiologicalProcess propionate metabolic process The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants. go.json propanoate metabolic process|propanoate metabolism|propionate metabolism http://purl.obolibrary.org/obo/GO_0019541 GO:0019519 biolink:BiologicalProcess pentitol metabolic process The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule. go.json pentitol metabolism http://purl.obolibrary.org/obo/GO_0019519 GO:0019517 biolink:BiologicalProcess L-threonine catabolic process to D-lactate The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. MetaCyc:THRDLCTCAT-PWY go.json L-threonine breakdown to D-lactate|L-threonine catabolic process to (R)-lactate|L-threonine catabolic process to methylglyoxal|L-threonine catabolic process to pyruvate|L-threonine catabolism to D-lactate|L-threonine degradation to D-lactate|threonine catabolic process to D-lactate http://purl.obolibrary.org/obo/GO_0019517 GO:0019518 biolink:BiologicalProcess L-threonine catabolic process to glycine The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine. MetaCyc:THREONINE-DEG2-PWY go.json L-threonine breakdown to glycine|L-threonine catabolic process to pyruvate|L-threonine catabolism to glycine|L-threonine degradation to glycine|threonine catabolic process to glycine http://purl.obolibrary.org/obo/GO_0019518 GO:0019515 biolink:BiologicalProcess lactose catabolic process via UDP-galactose The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose. go.json lactose breakdown via UDP-galactose|lactose degradation via UDP-galactose http://purl.obolibrary.org/obo/GO_0019515 GO:0019516 biolink:BiologicalProcess lactate oxidation The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons. go.json http://purl.obolibrary.org/obo/GO_0019516 GO:0019513 biolink:BiologicalProcess lactose catabolic process, using glucoside 3-dehydrogenase The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase. MetaCyc:LACTOSEUTIL-PWY go.json lactose breakdown, using glucoside 3-dehydrogenase|lactose degradation, using glucoside 3-dehydrogenase http://purl.obolibrary.org/obo/GO_0019513 GO:0019514 biolink:BiologicalProcess obsolete lactose hydrolysis OBSOLETE. (Was not defined before being made obsolete). go.json lactose hydrolysis True http://purl.obolibrary.org/obo/GO_0019514 GO:0019511 biolink:BiologicalProcess peptidyl-proline hydroxylation The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. go.json http://purl.obolibrary.org/obo/GO_0019511 gocheck_do_not_annotate GO:0019512 biolink:BiologicalProcess lactose catabolic process via tagatose-6-phosphate The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate. MetaCyc:LACTOSECAT-PWY go.json lactose breakdown via tagatose-6-phosphate|lactose degradation via tagatose-6-phosphate http://purl.obolibrary.org/obo/GO_0019512 GO:0019510 biolink:BiologicalProcess S-adenosylhomocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine. MetaCyc:ADENOSYLHOMOCYSCAT-PWY go.json S-adenosylhomocysteine breakdown|S-adenosylhomocysteine catabolism|S-adenosylhomocysteine degradation http://purl.obolibrary.org/obo/GO_0019510 GO:0019528 biolink:BiologicalProcess D-arabitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate. MetaCyc:DARABITOLUTIL-PWY go.json D-arabitol breakdown to xylulose 5-phosphate|D-arabitol degradation|D-arabitol degradation to xylulose 5-phosphate|D-arabitol utilization http://purl.obolibrary.org/obo/GO_0019528 GO:0019529 biolink:BiologicalProcess taurine catabolic process The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. MetaCyc:TAURINEDEG-PWY go.json taurine breakdown|taurine catabolism|taurine degradation http://purl.obolibrary.org/obo/GO_0019529 GO:0019526 biolink:BiologicalProcess pentitol biosynthetic process The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule. go.json pentitol anabolism|pentitol biosynthesis|pentitol formation|pentitol synthesis http://purl.obolibrary.org/obo/GO_0019526 GO:0019527 biolink:BiologicalProcess pentitol catabolic process The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule. go.json pentitol breakdown|pentitol catabolism|pentitol degradation http://purl.obolibrary.org/obo/GO_0019527 GO:0019524 biolink:BiologicalProcess keto-D-gluconate catabolic process The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose. MetaCyc:DHGLUCONATE-PYR-CAT-PWY go.json keto-D-gluconate breakdown|keto-D-gluconate catabolism|keto-D-gluconate degradation http://purl.obolibrary.org/obo/GO_0019524 GO:0019525 biolink:BiologicalProcess keto-D-gluconate metabolic process The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose. go.json keto-D-gluconate metabolism http://purl.obolibrary.org/obo/GO_0019525 GO:0019522 biolink:BiologicalProcess ketogluconate metabolic process The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. MetaCyc:KETOGLUCONMET-PWY go.json ketogluconate metabolism http://purl.obolibrary.org/obo/GO_0019522 GO:0019523 biolink:BiologicalProcess L-idonate metabolic process The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. MetaCyc:IDNCAT-PWY go.json L-idonate metabolism http://purl.obolibrary.org/obo/GO_0019523 GO:0019520 biolink:BiologicalProcess aldonic acid metabolic process The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. go.json aldonic acid metabolism http://purl.obolibrary.org/obo/GO_0019520 GO:0019521 biolink:BiologicalProcess D-gluconate metabolic process The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. go.json D-gluconate metabolism http://purl.obolibrary.org/obo/GO_0019521 GO:0044500 biolink:BiologicalProcess envenomation resulting in negative regulation of blood pressure in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism. go.json envenomation resulting in negative regulation of blood pressure in other organism|hypotensive activity in other organism http://purl.obolibrary.org/obo/GO_0044500 GO:0044501 biolink:BiologicalProcess perturbation of signal transduction in another organism The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism. go.json modulation of signal transduction in another organism|modulation of signal transduction in other organism http://purl.obolibrary.org/obo/GO_0044501 GO:0044508 biolink:MolecularActivity glucagon-like peptide 1 receptor activity Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein. go.json http://purl.obolibrary.org/obo/GO_0044508 GO:0044509 biolink:BiologicalProcess envenomation resulting in modulation of signal transduction in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism. go.json envenomation resulting in modulation of signal transduction in other organismm http://purl.obolibrary.org/obo/GO_0044509 GO:0044506 biolink:BiologicalProcess modulation of glucagon-like peptide receptor 1 activity in another organism The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism. go.json modulation of glucagon-like peptide receptor 1 activity in other organism|regulation of glucagon-like peptide receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044506 GO:0044507 biolink:BiologicalProcess positive regulation of receptor activity in another organism A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism. go.json positive regulation of receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044507 gocheck_do_not_annotate GO:0044504 biolink:BiologicalProcess modulation of receptor activity in another organism The process in which an organism effects a change in the activity of a receptor in a second organism. go.json modulation of receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044504 GO:0044505 biolink:BiologicalProcess positive regulation of G protein-coupled receptor activity in another organism A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism. go.json positive regulation of G protein-coupled receptor activity in other organism|positive regulation of G-protein coupled receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044505 gocheck_do_not_annotate GO:0044502 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044502 GO:0044503 biolink:BiologicalProcess modulation of G protein-coupled receptor activity in another organism The process in which an organism effects a change in the activity of a G protein-coupled receptor in a second organism. go.json modulation of G protein-coupled receptor activity in other organism|modulation of G-protein coupled receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044503 GO:0044511 biolink:BiologicalProcess envenomation resulting in modulation of receptor activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism. go.json envenomation resulting in modulation of receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044511 GO:0044512 biolink:BiologicalProcess envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism. go.json envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism http://purl.obolibrary.org/obo/GO_0044512 GO:0044510 biolink:BiologicalProcess envenomation resulting in positive regulation of signal transduction in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism. go.json envenomation resulting in positive regulation of signal transduction in other organism http://purl.obolibrary.org/obo/GO_0044510 GO:0044519 biolink:BiologicalProcess envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism. go.json envenomation resulting in modulation of VIP receptor activity in other organism|envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism|envenomation resulting in regulation of VIP receptor activity in other organism|envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044519 GO:0044517 biolink:BiologicalProcess modulation of vasoactive intestinal polypeptide receptor activity in another organism The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism. go.json modulation of VIP receptor activity in other organism|modulation of vasoactive intestinal polypeptide receptor activity in other organism|regulation of vasoactive intestinal polypeptide receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044517 GO:0044518 biolink:BiologicalProcess positive regulation of vasoactive intestinal polypeptide receptor activity in another organism A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism. go.json positive regulation of VIP receptor activity in other organism|positive regulation of vasoactive intestinal polypeptide receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044518 gocheck_do_not_annotate GO:0044515 biolink:BiologicalProcess envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism. go.json envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism http://purl.obolibrary.org/obo/GO_0044515 GO:0044516 biolink:BiologicalProcess positive regulation of glucagon-like peptide receptor 1 activity in another organism A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism. go.json positive regulation of glucagon-like peptide receptor 1 activity in other organism http://purl.obolibrary.org/obo/GO_0044516 gocheck_do_not_annotate GO:0044513 biolink:BiologicalProcess envenomation resulting in modulation of G protein-coupled receptor activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism. go.json envenomation resulting in modulation of G protein-coupled receptor activity in other organism|envenomation resulting in modulation of G-protein coupled receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044513 GO:0044514 biolink:BiologicalProcess envenomation resulting in positive regulation of G protein-coupled receptor activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism. go.json envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism|envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044514 GO:0044522 biolink:BiologicalProcess envenomation resulting in myocyte killing in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism. go.json envenomation resulting in myocyte killing causing muscle damage in other organism|envenomation resulting in myocyte killing in other organism http://purl.obolibrary.org/obo/GO_0044522 GO:0044523 biolink:BiologicalProcess envenomation resulting in damage of muscle extracellular matrix in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism. go.json envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism|envenomation resulting in damage of muscle extracellular matrix in other organism http://purl.obolibrary.org/obo/GO_0044523 GO:0044520 biolink:BiologicalProcess envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism. go.json envenomation resulting in positive regulation of VIP receptor activity in other organism|envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism http://purl.obolibrary.org/obo/GO_0044520 GO:0044521 biolink:BiologicalProcess envenomation resulting in muscle damage in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism. go.json envenomation resulting in muscle damage in other organism http://purl.obolibrary.org/obo/GO_0044521 GO:0044528 biolink:BiologicalProcess regulation of mitochondrial mRNA stability Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs. go.json http://purl.obolibrary.org/obo/GO_0044528 GO:0044529 biolink:BiologicalProcess regulation of mitochondrial rRNA stability Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs. go.json http://purl.obolibrary.org/obo/GO_0044529 GO:0044526 biolink:BiologicalProcess formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide. go.json http://purl.obolibrary.org/obo/GO_0044526 gocheck_do_not_annotate GO:0044527 biolink:BiologicalProcess formation of peptidyl-cystine persulfide by sulphur transfer from H2S The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide. go.json http://purl.obolibrary.org/obo/GO_0044527 gocheck_do_not_annotate GO:0044524 biolink:BiologicalProcess protein sulfhydration The modification of a protein amino acid by the addition of sulfur. go.json http://purl.obolibrary.org/obo/GO_0044524 gocheck_do_not_annotate GO:0044525 biolink:BiologicalProcess peptidyl-cystine sulfhydration The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide. go.json http://purl.obolibrary.org/obo/GO_0044525 gocheck_do_not_annotate GO:0019599 biolink:BiologicalProcess (R)-4-hydroxymandelate catabolic process The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid. MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY go.json (R)-4-hydroxymandelate breakdown|(R)-4-hydroxymandelate catabolism|(R)-4-hydroxymandelate degradation http://purl.obolibrary.org/obo/GO_0019599 GO:0019597 biolink:BiologicalProcess (R)-mandelate catabolic process to benzoate The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate. go.json (R)-mandelate breakdown to benzoate|(R)-mandelate degradation to benzoate http://purl.obolibrary.org/obo/GO_0019597 GO:0019598 biolink:BiologicalProcess (R)-mandelate catabolic process to catechol The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol. go.json (R)-mandelate breakdown to catechol|(R)-mandelate degradation to catechol http://purl.obolibrary.org/obo/GO_0019598 GO:0019595 biolink:BiologicalProcess non-phosphorylated glucose catabolic process The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose. MetaCyc:NPGLUCAT-PWY go.json non-phosphorylated glucose breakdown|non-phosphorylated glucose catabolism|non-phosphorylated glucose degradation http://purl.obolibrary.org/obo/GO_0019595 GO:0019596 biolink:BiologicalProcess mandelate catabolic process The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. go.json mandelate breakdown|mandelate catabolism|mandelate degradation http://purl.obolibrary.org/obo/GO_0019596 GO:0019593 biolink:BiologicalProcess mannitol biosynthetic process The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. MetaCyc:PWY-3881 go.json mannitol anabolism|mannitol biosynthesis|mannitol formation|mannitol synthesis http://purl.obolibrary.org/obo/GO_0019593 GO:0019594 biolink:BiologicalProcess mannitol metabolic process The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. go.json mannitol metabolism http://purl.obolibrary.org/obo/GO_0019594 GO:0044533 biolink:BiologicalProcess positive regulation of apoptotic process in another organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism. go.json positive regulation of apoptotic process in other organism http://purl.obolibrary.org/obo/GO_0044533 GO:0044534 biolink:BiologicalProcess envenomation resulting in modulation of apoptotic process in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism. go.json envenomation resulting in modulation of apoptotic process in other organism http://purl.obolibrary.org/obo/GO_0044534 GO:0044531 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044531 GO:0044532 biolink:BiologicalProcess modulation of apoptotic process in another organism A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism. go.json modulation of apoptotic process in other organism|regulation of apoptotic process in other organism http://purl.obolibrary.org/obo/GO_0044532 GO:0044530 biolink:CellularComponent supraspliceosomal complex Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing. go.json supraspliceosome complex http://purl.obolibrary.org/obo/GO_0044530 GO:0044539 biolink:BiologicalProcess long-chain fatty acid import into cell The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json long-chain fatty acid import|long-chain fatty acid uptake http://purl.obolibrary.org/obo/GO_0044539 GO:0044537 biolink:BiologicalProcess regulation of circulating fibrinogen levels Any process that modulates the quantity of fibrinogen circulating in the bloodstream. go.json http://purl.obolibrary.org/obo/GO_0044537 GO:0044538 biolink:CellularComponent host cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell. go.json http://purl.obolibrary.org/obo/GO_0044538 GO:0044535 biolink:MolecularActivity very-long-chain fatty acyl-CoA oxidase activity Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. go.json VLC fatty-acyl-CoA oxidase activity|very long chain fatty-acyl-CoA oxidase activity|very-long-chain acyl-CoA oxidase activity http://purl.obolibrary.org/obo/GO_0044535 GO:0044536 biolink:BiologicalProcess envenomation resulting in depletion of circulating fibrinogen in another organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism. go.json envenomation resulting in depletion of circulating fibrinogen in other organism|envenomation resulting in negative regulation of circulating fibrinogen in other organism http://purl.obolibrary.org/obo/GO_0044536 GO:0019508 biolink:BiologicalProcess 2,5-dihydroxypyridine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate. MetaCyc:PWY-722 go.json 2,5-dihydroxypyridine breakdown to fumarate|2,5-dihydroxypyridine degradation to fumarate|2,5-dihydroxypyridine utilization|maleamate pathway|pyridine-2,5-diol catabolic process to fumarate http://purl.obolibrary.org/obo/GO_0019508 GO:0019509 biolink:BiologicalProcess L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. MetaCyc:PWY-4361 go.json methionine recycling|methionine regeneration|methionine salvage from methylthioadenosine|methionine salvage pathway http://purl.obolibrary.org/obo/GO_0019509 GO:0019506 biolink:BiologicalProcess phenylmercury acetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. MetaCyc:P641-PWY go.json phenylmercury acetate breakdown|phenylmercury acetate catabolism|phenylmercury acetate degradation http://purl.obolibrary.org/obo/GO_0019506 GO:0019507 biolink:BiologicalProcess pyridine metabolic process The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. go.json pyridine metabolism http://purl.obolibrary.org/obo/GO_0019507 GO:0019504 biolink:BiologicalProcess L-proline betaine catabolic process The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline. MetaCyc:P561-PWY go.json stachydrine breakdown|stachydrine catabolic process|stachydrine catabolism|stachydrine degradation http://purl.obolibrary.org/obo/GO_0019504 GO:0019505 biolink:BiologicalProcess resorcinol metabolic process The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic. MetaCyc:P343-PWY go.json 1,3-benzenediol metabolic process|1,3-benzenediol metabolism|1,3-dihydroxybenzene metabolic process|1,3-dihydroxybenzene metabolism|resorcinol metabolism http://purl.obolibrary.org/obo/GO_0019505 GO:0019502 biolink:BiologicalProcess L-proline betaine metabolic process The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants. go.json stachydrine metabolic process|stachydrine metabolism http://purl.obolibrary.org/obo/GO_0019502 GO:0019503 biolink:BiologicalProcess L-proline betaine biosynthetic process The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline. go.json stachydrine anabolism|stachydrine biosynthesis|stachydrine biosynthetic process|stachydrine formation|stachydrine synthesis http://purl.obolibrary.org/obo/GO_0019503 GO:0019500 biolink:BiologicalProcess cyanide catabolic process The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. MetaCyc:P401-PWY go.json cyanide breakdown|cyanide catabolism|cyanide degradation http://purl.obolibrary.org/obo/GO_0019500 GO:0019501 biolink:BiologicalProcess arsonoacetate catabolic process The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom. MetaCyc:P482-PWY go.json arsonoacetate breakdown|arsonoacetate catabolism|arsonoacetate degradation http://purl.obolibrary.org/obo/GO_0019501 GO:0030019 biolink:MolecularActivity obsolete tryptase activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin. go.json lung tryptase activity|mast cell neutral proteinase activity|mast cell protease II activity|mast cell proteinase II|mast cell serine proteinase II|mast cell serine proteinase tryptase activity|mast cell tryptase activity|pituitary tryptase activity|rat mast cell protease II|skin tryptase activity|tryptase M|tryptase activity True http://purl.obolibrary.org/obo/GO_0030019 GO:0030017 biolink:CellularComponent sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. Wikipedia:Sarcomere go.json http://purl.obolibrary.org/obo/GO_0030017 GO:0030018 biolink:CellularComponent Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. go.json Z band|Z disk|Z line http://purl.obolibrary.org/obo/GO_0030018 GO:0030015 biolink:CellularComponent CCR4-NOT core complex The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. go.json http://purl.obolibrary.org/obo/GO_0030015 GO:0030016 biolink:CellularComponent myofibril The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. Wikipedia:Myofibril go.json http://purl.obolibrary.org/obo/GO_0030016 GO:0044665 biolink:CellularComponent MLL1/2 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. go.json Trx-containing complex http://purl.obolibrary.org/obo/GO_0044665 GO:0005057 biolink:MolecularActivity obsolete signal transducer activity, downstream of receptor OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. go.json intracellular signal transducer activity|receptor signaling protein activity|receptor signalling protein activity True http://purl.obolibrary.org/obo/GO_0005057 GO:0044666 biolink:CellularComponent MLL3/4 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species. go.json Trr/COMPASS-like complex http://purl.obolibrary.org/obo/GO_0044666 GO:0005055 biolink:MolecularActivity laminin receptor activity Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0005055 GO:0044663 biolink:BiologicalProcess establishment or maintenance of cell type involved in phenotypic switching A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. go.json http://purl.obolibrary.org/obo/GO_0044663 GO:0044664 biolink:BiologicalProcess obsolete reversion of cell type to default state involved in phenotypic switching OBSOLETE. The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. go.json True http://purl.obolibrary.org/obo/GO_0044664 GO:0005056 biolink:MolecularActivity tiggrin receptor activity Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0005056 GO:0005053 biolink:MolecularActivity peroxisome matrix targeting signal-2 binding Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). go.json PEX7|PTS2 binding|PTS2 receptor|peroxisomal targeting signal 2 (PTS2) binding|peroxisome targeting signal-2 binding|peroxisome targeting signal-2 receptor http://purl.obolibrary.org/obo/GO_0005053 GO:0044661 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044661 GO:0044662 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044662 GO:0005054 biolink:MolecularActivity obsolete peroxisome integral membrane receptor OBSOLETE. (Was not defined before being made obsolete). go.json Pas20p|peroxisome integral membrane receptor True http://purl.obolibrary.org/obo/GO_0005054 GO:0005051 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005051 GO:0044660 biolink:BiologicalProcess viral release via pore formation in host cell membrane The dissemination of mature viral particles from a host cell via the formation by the virus of pores in its host cell membrane. go.json cytolysis by virus via pore formation in host cell membrane|viral exit by cytolysis via pore formation in host cell membrane|viral release by cytolysis via pore formation in host cell membrane http://purl.obolibrary.org/obo/GO_0044660 GO:0005052 biolink:MolecularActivity peroxisome matrix targeting signal-1 binding Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L. go.json PEX5|PTS1 binding|PTS1 receptor|peroxisomal targeting signal 1 (PTS1) binding|peroxisome targeting signal-1 binding|peroxisome targeting signal-1 receptor http://purl.obolibrary.org/obo/GO_0005052 GO:0005061 biolink:MolecularActivity obsolete aryl hydrocarbon receptor nuclear translocator activity OBSOLETE. (Was not defined before being made obsolete). go.json aryl hydrocarbon receptor nuclear translocator activity True http://purl.obolibrary.org/obo/GO_0005061 GO:0044669 biolink:MolecularActivity sodium:galactoside symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in). go.json http://purl.obolibrary.org/obo/GO_0044669 GO:0044667 biolink:MolecularActivity (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out). RHEA:29427 go.json (R)-carnitine:gamma-butyrobetaine antiporter activity|L-carnitine:4-(trimethylammonio)butanoate antiporter activity|L-carnitine:gamma-butyrobetaine antiporter activity http://purl.obolibrary.org/obo/GO_0044667 GO:0044668 biolink:MolecularActivity sodium:malonate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in). RHEA:33135 go.json http://purl.obolibrary.org/obo/GO_0044668 GO:0019698 biolink:BiologicalProcess D-galacturonate catabolic process The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. MetaCyc:GALACTUROCAT-PWY go.json D-galacturonate breakdown|D-galacturonate catabolism|D-galacturonate degradation http://purl.obolibrary.org/obo/GO_0019698 GO:0030013 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030013 GO:0030014 biolink:CellularComponent CCR4-NOT complex The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. go.json http://purl.obolibrary.org/obo/GO_0030014 GO:0019699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019699 GO:0030011 biolink:BiologicalProcess maintenance of cell polarity The maintenance of established anisotropic intracellular organization or cell growth patterns. go.json http://purl.obolibrary.org/obo/GO_0030011 GO:0019696 biolink:BiologicalProcess toluene oxidation via toluene-cis-1,2-dihydrodiol The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol. MetaCyc:TOLUENE-DEG-DIOL-PWY go.json http://purl.obolibrary.org/obo/GO_0019696 GO:0019697 biolink:BiologicalProcess L-xylitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. MetaCyc:LARABITOLUTIL-PWY go.json L-arabitol and xylitol degradation|L-xylitol breakdown to xylulose 5-phosphate|L-xylitol degradation to xylulose 5-phosphate|L-xylitol utilization http://purl.obolibrary.org/obo/GO_0019697 GO:0030012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030012 GO:0019694 biolink:BiologicalProcess alkanesulfonate metabolic process The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. MetaCyc:ALKANEMONOX-PWY go.json alkanesulfonate metabolism|alkanesulphonate metabolic process|alkanesulphonate metabolism http://purl.obolibrary.org/obo/GO_0019694 GO:0019695 biolink:BiologicalProcess choline metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. go.json choline metabolism http://purl.obolibrary.org/obo/GO_0019695 GO:0030010 biolink:BiologicalProcess establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns. go.json bud site selection/establishment of cell polarity|cell polarization http://purl.obolibrary.org/obo/GO_0030010 GO:0019692 biolink:BiologicalProcess deoxyribose phosphate metabolic process The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. go.json deoxyribose phosphate metabolism http://purl.obolibrary.org/obo/GO_0019692 GO:0019693 biolink:BiologicalProcess ribose phosphate metabolic process The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar. go.json ribose phosphate metabolism http://purl.obolibrary.org/obo/GO_0019693 GO:0030008 biolink:CellularComponent TRAPP complex A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active. Wikipedia:TRAPP_complex go.json TRAPP1|TRAPP2|transport protein particle|transport protein particle complex http://purl.obolibrary.org/obo/GO_0030008 GO:0030009 biolink:MolecularActivity obsolete complement factor H activity OBSOLETE. A cofactor for the serine protease complement factor I. go.json complement factor H activity True http://purl.obolibrary.org/obo/GO_0030009 GO:0030006 biolink:BiologicalProcess obsolete heavy cellular metal ion homeostasis OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. go.json heavy cellular metal ion homeostasis True http://purl.obolibrary.org/obo/GO_0030006 GO:0030007 biolink:BiologicalProcess intracellular potassium ion homeostasis A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. go.json cellular potassium ion homeostasis http://purl.obolibrary.org/obo/GO_0030007 GO:0030004 biolink:BiologicalProcess obsolete cellular monovalent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. go.json True http://purl.obolibrary.org/obo/GO_0030004 GO:0030005 biolink:BiologicalProcess obsolete cellular di-, tri-valent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell. go.json cellular di-, tri-valent inorganic cation homeostasis True http://purl.obolibrary.org/obo/GO_0030005 GO:0044676 biolink:CellularComponent formyl-methanofuran dehydrogenase (molybdenum enzyme) complex A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis. go.json http://purl.obolibrary.org/obo/GO_0044676 GO:0005068 biolink:MolecularActivity transmembrane receptor protein tyrosine kinase adaptor activity The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. go.json transmembrane receptor protein tyrosine kinase adaptor protein activity|transmembrane receptor protein tyrosine kinase docking protein activity http://purl.obolibrary.org/obo/GO_0005068 GO:0044677 biolink:CellularComponent methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis. go.json 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex|N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex|coenzyme M methyltransferase complex|methyl-H4MPT http://purl.obolibrary.org/obo/GO_0044677 GO:0005069 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005069 GO:0044674 biolink:CellularComponent methyl coenzyme M reductase complex A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis. go.json http://purl.obolibrary.org/obo/GO_0044674 GO:0005066 biolink:MolecularActivity obsolete transmembrane receptor protein tyrosine kinase signaling protein activity OBSOLETE. (Was not defined before being made obsolete). go.json transmembrane receptor protein tyrosine kinase signaling protein activity|transmembrane receptor protein tyrosine kinase signalling protein activity True http://purl.obolibrary.org/obo/GO_0005066 GO:0044675 biolink:CellularComponent formyl-methanofuran dehydrogenase (tungsten enzyme) complex A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis. go.json http://purl.obolibrary.org/obo/GO_0044675 GO:0005067 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005067 GO:0044672 biolink:CellularComponent acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis. go.json CO dehydrogenase complex|CO dehydrogenase/acetyl-CoA synthase complex|CODH|CODH/ACS complex|carbon monoxide dehydrogenase|carbon-monoxide:(acceptor) oxidoreductase complex http://purl.obolibrary.org/obo/GO_0044672 GO:0044673 biolink:CellularComponent 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420. go.json FO-synthase complex http://purl.obolibrary.org/obo/GO_0044673 GO:0005065 biolink:MolecularActivity obsolete heterotrimeric G-protein OBSOLETE. (Was not defined before being made obsolete). go.json heterotrimeric G-protein True http://purl.obolibrary.org/obo/GO_0005065 GO:0044670 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044670 GO:0005062 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005062 GO:0044671 biolink:BiologicalProcess sorocarp spore cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass). go.json http://purl.obolibrary.org/obo/GO_0044671 GO:0005071 biolink:MolecularActivity obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity OBSOLETE. (Was not defined before being made obsolete). go.json transmembrane receptor protein serine/threonine kinase signaling protein activity|transmembrane receptor protein serine/threonine kinase signalling protein activity True http://purl.obolibrary.org/obo/GO_0005071 GO:0005072 biolink:MolecularActivity obsolete transforming growth factor beta receptor, cytoplasmic mediator activity OBSOLETE. Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus. go.json TGF-beta receptor, cytoplasmic mediator activity|TGFbeta receptor, cytoplasmic mediator activity True http://purl.obolibrary.org/obo/GO_0005072 GO:0005070 biolink:MolecularActivity obsolete SH3/SH2 adaptor activity OBSOLETE. Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). go.json SH3/SH2 adaptor protein activity True http://purl.obolibrary.org/obo/GO_0005070 GO:0044678 biolink:CellularComponent CoB-CoM heterodisulfide reductase complex A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine. go.json coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex|hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex http://purl.obolibrary.org/obo/GO_0044678 GO:0044679 biolink:CellularComponent methanophenazine reducing hydrogenase complex A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides. go.json http://purl.obolibrary.org/obo/GO_0044679 GO:0030002 biolink:BiologicalProcess intracellular monoatomic anion homeostasis A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom. go.json cellular anion homeostasis|cellular monoatomic anion homeostasis http://purl.obolibrary.org/obo/GO_0030002 GO:0030003 biolink:BiologicalProcess intracellular monoatomic cation homeostasis A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom. go.json cellular cation homeostasis|cellular monoatomic cation homeostasis http://purl.obolibrary.org/obo/GO_0030003 GO:0030001 biolink:BiologicalProcess metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json divalent metal ion export|divalent metal ion transport|heavy metal ion transport|metal ion export http://purl.obolibrary.org/obo/GO_0030001 GO:0044680 biolink:CellularComponent methylthiol:coenzyme M methyltransferase complex A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis. go.json methylthiol coenzyme M methyl transferase complex|methylthiol:CoM methyltransferase complex|methylthiol:coenzyme M methyl transferase complex http://purl.obolibrary.org/obo/GO_0044680 GO:0019680 biolink:BiologicalProcess L-methylmalonyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. MetaCyc:PWY0-43 go.json L-methylmalonyl-CoA anabolism|L-methylmalonyl-CoA biosynthesis|L-methylmalonyl-CoA formation|L-methylmalonyl-CoA synthesis http://purl.obolibrary.org/obo/GO_0019680 GO:0005039 biolink:MolecularActivity obsolete death receptor-associated factor activity OBSOLETE. (Was not defined before being made obsolete). go.json death receptor-associated factor activity True http://purl.obolibrary.org/obo/GO_0005039 GO:0005037 biolink:MolecularActivity obsolete death receptor adaptor protein activity OBSOLETE. (Was not defined before being made obsolete). go.json death receptor adaptor protein activity True http://purl.obolibrary.org/obo/GO_0005037 GO:0005038 biolink:MolecularActivity obsolete death receptor interacting protein activity OBSOLETE. (Was not defined before being made obsolete). go.json death receptor interacting protein activity True http://purl.obolibrary.org/obo/GO_0005038 GO:0044687 biolink:MolecularActivity geranylfarnesyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate. EC:2.5.1.81|MetaCyc:RXN-8813|RHEA:25694 go.json http://purl.obolibrary.org/obo/GO_0044687 GO:0005035 biolink:MolecularActivity death receptor activity Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. go.json apoptosis-activating receptor activity http://purl.obolibrary.org/obo/GO_0005035 GO:0044688 biolink:MolecularActivity 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+. go.json http://purl.obolibrary.org/obo/GO_0044688 GO:0044685 biolink:MolecularActivity tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O. EC:2.1.2.- go.json http://purl.obolibrary.org/obo/GO_0044685 GO:0005033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005033 GO:0044686 biolink:MolecularActivity cysteate synthase activity Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-. EC:2.5.1.76|MetaCyc:RXN-11108|RHEA:26486 go.json http://purl.obolibrary.org/obo/GO_0044686 GO:0005034 biolink:MolecularActivity osmosensor activity Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. go.json http://purl.obolibrary.org/obo/GO_0005034 GO:0005031 biolink:MolecularActivity tumor necrosis factor receptor activity Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. go.json NGF/TNF (6 C-domain) receptor activity|TNF receptor activity|TNF receptor activity, type I|TNF receptor activity, type II|tumor necrosis factor receptor activity, type I|tumor necrosis factor receptor activity, type II|tumor necrosis factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0005031 GO:0044683 biolink:MolecularActivity methylthiol:coenzyme M methyltransferase activity Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM. EC:2.1.1.251|MetaCyc:RXN-8125|RHEA:32667 go.json methylthiol:coenzyme M methyl transferase activity http://purl.obolibrary.org/obo/GO_0044683 GO:0044684 biolink:MolecularActivity dihydromethanopterin reductase activity Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP. EC:1.5.99.15|RHEA:42804 go.json http://purl.obolibrary.org/obo/GO_0044684 GO:0005032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005032 GO:0044681 biolink:CellularComponent sulfopyruvate decarboxylase complex A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0044681 GO:0005030 biolink:MolecularActivity neurotrophin receptor activity Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0005030 GO:0044682 biolink:MolecularActivity archaeal-specific GTP cyclohydrolase activity Catalysis of the reaction: GTP + H2O = 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+. go.json Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity|MptA activity http://purl.obolibrary.org/obo/GO_0044682 GO:0044689 biolink:MolecularActivity 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity Catalysis of the reaction: 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H+ + L-methionine + NH4+. EC:4.3.1.32|MetaCyc:RXN-19230|RHEA:55204 go.json FO synthase http://purl.obolibrary.org/obo/GO_0044689 GO:0019678 biolink:BiologicalProcess propionate metabolic process, methylmalonyl pathway The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway. MetaCyc:PROPIONMET-PWY go.json propionate metabolism, methylmalonyl pathway http://purl.obolibrary.org/obo/GO_0019678 GO:0019679 biolink:BiologicalProcess propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle. MetaCyc:PWY0-42 go.json propionate metabolism, methylcitrate cycle http://purl.obolibrary.org/obo/GO_0019679 GO:0019676 biolink:BiologicalProcess ammonia assimilation cycle The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. MetaCyc:AMMASSIM-PWY|MetaCyc:PWY-3282 go.json glutamate metabolic process via glutamine and ammonia|glutamate metabolism via glutamine and ammonia http://purl.obolibrary.org/obo/GO_0019676 GO:0019677 biolink:BiologicalProcess NAD catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH. go.json NAD (oxidized) catabolic process|NAD (oxidized) catabolism|NAD (reduced) catabolic process|NAD (reduced) catabolism|NAD breakdown|NAD catabolism|NAD degradation|NADH catabolic process|NADH catabolism|nicotinamide adenine dinucleotide catabolic process|nicotinamide adenine dinucleotide catabolism|oxidized NAD catabolic process|oxidized NAD catabolism|oxidized nicotinamide adenine dinucleotide catabolic process|oxidized nicotinamide adenine dinucleotide catabolism|reduced NAD catabolic process|reduced NAD catabolism|reduced nicotinamide adenine dinucleotide catabolic process|reduced nicotinamide adenine dinucleotide catabolism http://purl.obolibrary.org/obo/GO_0019677 GO:0019674 biolink:BiologicalProcess NAD metabolic process The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. go.json NAD (oxidized) metabolic process|NAD (oxidized) metabolism|NAD metabolism|NAD phosphorylation and dephosphorylation|nicotinamide adenine dinucleotide metabolic process|nicotinamide adenine dinucleotide metabolism|oxidized NAD metabolic process|oxidized NAD metabolism|oxidized nicotinamide adenine dinucleotide metabolic process|oxidized nicotinamide adenine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_0019674 GO:0019675 biolink:BiologicalProcess obsolete NAD phosphorylation and dephosphorylation OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. go.json NAD phosphorylation and dephosphorylation|nicotinamide adenine dinucleotide phosphorylation and dephosphorylation True http://purl.obolibrary.org/obo/GO_0019675 GO:0019672 biolink:BiologicalProcess ethanol-acetate fermentation to butyrate and caproate The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP. go.json http://purl.obolibrary.org/obo/GO_0019672 GO:0019673 biolink:BiologicalProcess GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. go.json GDP-mannose metabolism http://purl.obolibrary.org/obo/GO_0019673 GO:0019670 biolink:BiologicalProcess anaerobic glutamate catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP. go.json glutamate fermentation http://purl.obolibrary.org/obo/GO_0019670 GO:0019671 biolink:BiologicalProcess glutamate catabolic process via mesaconate and citramalate The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP. MetaCyc:GLUDEG-II-PWY|MetaCyc:PWY-5087|MetaCyc:PWY-5088 go.json glutamate fermentation via mesaconate and citramalate http://purl.obolibrary.org/obo/GO_0019671 GO:0019690 biolink:BiologicalProcess pyrimidine deoxyribonucleoside interconversion The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside. go.json http://purl.obolibrary.org/obo/GO_0019690 GO:0044690 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044690 GO:0044691 biolink:BiologicalProcess tooth eruption The tooth development process in which the teeth enter the mouth and become visible. Wikipedia:Tooth_eruption go.json http://purl.obolibrary.org/obo/GO_0044691 GO:0019691 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019691 GO:0005048 biolink:MolecularActivity signal sequence binding Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. go.json leader sequence binding|protein signal sequence binding|signal sequence receptor http://purl.obolibrary.org/obo/GO_0005048 GO:0005049 biolink:MolecularActivity nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. Reactome:R-HSA-178215 go.json NES receptor|exportin activity|importin-alpha binding|importin-alpha export receptor activity http://purl.obolibrary.org/obo/GO_0005049 GO:0044698 biolink:BiologicalProcess obsolete morphogenesis of symbiont in host cell OBSOLETE. The process in which a symbiont undergoes a change in shape or form, within the host's cell. go.json True http://purl.obolibrary.org/obo/GO_0044698 GO:0005046 biolink:MolecularActivity KDEL sequence binding Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. go.json KDEL receptor activity http://purl.obolibrary.org/obo/GO_0005046 GO:0005047 biolink:MolecularActivity signal recognition particle binding Binding to a signal recognition particle. go.json docking protein|signal recognition particle receptor http://purl.obolibrary.org/obo/GO_0005047 GO:0044699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044699 GO:0044696 biolink:BiologicalProcess killing by virus of host cell by post-segregational killing The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes. go.json killing by virus of host cell by PSK|killing by virus of host cell by toxin-antitoxin system http://purl.obolibrary.org/obo/GO_0044696 GO:0005044 biolink:MolecularActivity scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). go.json macrophage receptor activity http://purl.obolibrary.org/obo/GO_0005044 goslim_chembl GO:0044697 biolink:CellularComponent HICS complex A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins. go.json http://purl.obolibrary.org/obo/GO_0044697 GO:0005045 biolink:MolecularActivity obsolete endoplasmic reticulum receptor activity OBSOLETE. A receptor in the endoplasmic reticulum. go.json endoplasmic reticulum receptor activity True http://purl.obolibrary.org/obo/GO_0005045 GO:0044694 biolink:BiologicalProcess pore-mediated entry of viral genome into host cell Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail. VZ:979 go.json membrane puncture-mediated penetration of viral genome into host cell|pore-mediated penetration of viral genome into host cell|viral entry via genome injection|viral genome delivery via icosahedral vertex|viral genome translocation|viral pore-forming protein http://purl.obolibrary.org/obo/GO_0044694 GO:0005042 biolink:MolecularActivity netrin receptor activity Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0005042 GO:0005043 biolink:MolecularActivity netrin receptor activity involved in chemorepulsion Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin. go.json netrin receptor activity involved in negative chemotaxis|repulsive netrin receptor activity http://purl.obolibrary.org/obo/GO_0005043 GO:0044695 biolink:CellularComponent Dsc E3 ubiquitin ligase complex An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism. go.json http://purl.obolibrary.org/obo/GO_0044695 GO:0044692 biolink:MolecularActivity exoribonuclease activator activity Binds to and increases the activity of an exoribonuclease. go.json http://purl.obolibrary.org/obo/GO_0044692 GO:0005040 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005040 GO:0044693 biolink:MolecularActivity trehalose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in). go.json trehalose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0044693 GO:0005041 biolink:MolecularActivity low-density lipoprotein particle receptor activity Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis. Reactome:R-HSA-2404131|Reactome:R-HSA-2424254|Wikipedia:LDL_receptor go.json LDL receptor|LDLR activity|low-density lipoprotein receptor activity http://purl.obolibrary.org/obo/GO_0005041 GO:0005050 biolink:MolecularActivity obsolete peroxisome receptor OBSOLETE. (Was not defined before being made obsolete). go.json peroxisome receptor True http://purl.obolibrary.org/obo/GO_0005050 RO:0002016 biolink:OntologyClass has necessary component activity RO:0002016 go.json http://purl.obolibrary.org/obo/RO_0002016 GO:0019689 biolink:BiologicalProcess pyrimidine nucleoside interconversion The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside. go.json http://purl.obolibrary.org/obo/GO_0019689 GO:0019687 biolink:BiologicalProcess pyruvate biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate. go.json pyruvate anabolism from acetate|pyruvate formation from acetate|pyruvate synthesis from acetate http://purl.obolibrary.org/obo/GO_0019687 GO:0019688 biolink:BiologicalProcess purine deoxyribonucleoside interconversion The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside. go.json http://purl.obolibrary.org/obo/GO_0019688 GO:0019685 biolink:BiologicalProcess photosynthesis, dark reaction A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions. go.json http://purl.obolibrary.org/obo/GO_0019685 GO:0019686 biolink:BiologicalProcess purine nucleoside interconversion The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside. go.json http://purl.obolibrary.org/obo/GO_0019686 GO:0019683 biolink:BiologicalProcess glyceraldehyde-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. go.json glyceraldehyde 3-phosphate catabolic process|glyceraldehyde 3-phosphate catabolism|glyceraldehyde-3-phosphate breakdown|glyceraldehyde-3-phosphate catabolism|glyceraldehyde-3-phosphate degradation http://purl.obolibrary.org/obo/GO_0019683 GO:0019684 biolink:BiologicalProcess photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. MetaCyc:PWY-101|Wikipedia:Photolysis#Photolysis_in_photosynthesis go.json photolysis http://purl.obolibrary.org/obo/GO_0019684 GO:0019681 biolink:BiologicalProcess acetyl-CoA assimilation pathway The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell. go.json acetyl-CoA catabolic process to 2-ketoglutarate|acetyl-CoA catabolic process to 2-oxoglutarate|acetyl-CoA catabolic process to alpha-ketoglutarate|acetyl-CoA catabolic process to alpha-oxoglutarate|acetyl-CoA catabolism to 2-ketoglutarate|acetyl-CoA catabolism to 2-oxoglutarate|acetyl-CoA catabolism to alpha-ketoglutarate|acetyl-CoA catabolism to alpha-oxoglutarate http://purl.obolibrary.org/obo/GO_0019681 GO:0019682 biolink:BiologicalProcess glyceraldehyde-3-phosphate metabolic process The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. go.json glyceraldehyde 3-phosphate metabolic process|glyceraldehyde 3-phosphate metabolism|glyceraldehyde-3-phosphate metabolism http://purl.obolibrary.org/obo/GO_0019682 GO:0005019 biolink:MolecularActivity platelet-derived growth factor beta-receptor activity Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. go.json PDGF beta-receptor activity|betaPDGF receptor activity http://purl.obolibrary.org/obo/GO_0005019 GO:0005017 biolink:MolecularActivity platelet-derived growth factor receptor activity Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json PDGF receptor activity|PDGF-activated receptor activity|PDGFR activity|platelet-derived growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0005017 GO:0005018 biolink:MolecularActivity platelet-derived growth factor alpha-receptor activity Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. go.json PDGF alpha-receptor activity|alphaPDGF receptor activity http://purl.obolibrary.org/obo/GO_0005018 GO:0005015 biolink:MolecularActivity obsolete neurotrophin TRKB receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json neurotrophin TRKB receptor activity True http://purl.obolibrary.org/obo/GO_0005015 GO:0005016 biolink:MolecularActivity obsolete neurotrophin TRKC receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json neurotrophin TRKC receptor activity True http://purl.obolibrary.org/obo/GO_0005016 GO:0005013 biolink:MolecularActivity obsolete neurotrophin TRK receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json neurotrophin TRK receptor activity True http://purl.obolibrary.org/obo/GO_0005013 GO:0005014 biolink:MolecularActivity obsolete neurotrophin TRKA receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json neurotrophin TRKA receptor activity True http://purl.obolibrary.org/obo/GO_0005014 RO:0002013 biolink:OntologyClass has regulatory component activity RO:0002013 go.json http://purl.obolibrary.org/obo/RO_0002013 GO:0005011 biolink:MolecularActivity macrophage colony-stimulating factor receptor activity Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. go.json CSF-1|Fms|M-CSF receptor activity|macrophage colony stimulating factor receptor activity http://purl.obolibrary.org/obo/GO_0005011 GO:0005012 biolink:MolecularActivity obsolete Neu/ErbB-2 receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json Neu/ErbB-2 receptor activity True http://purl.obolibrary.org/obo/GO_0005012 RO:0002014 biolink:OntologyClass has negative regulatory component activity RO:0002014 go.json http://purl.obolibrary.org/obo/RO_0002014 GO:0005010 biolink:MolecularActivity insulin-like growth factor receptor activity Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json IGF receptor activity|IGF-activated receptor activity|insulin-like growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0005010 RO:0002008 biolink:OntologyClass coincident with RO:0002008 go.json http://purl.obolibrary.org/obo/RO_0002008 GO:0019658 biolink:BiologicalProcess glucose fermentation to lactate and acetate The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP. MetaCyc:P124-PWY go.json bifidum pathway|glucose catabolic process to lactate and acetate http://purl.obolibrary.org/obo/GO_0019658 GO:0019659 biolink:BiologicalProcess glucose catabolic process to lactate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP). Wikipedia:Lactic_acid_fermentation go.json glucose fermentation to lactate|lactate fermentation http://purl.obolibrary.org/obo/GO_0019659 GO:0019656 biolink:BiologicalProcess glucose catabolic process to D-lactate and ethanol The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule. MetaCyc:P122-PWY go.json glucose fermentation to D-lactate and ethanol|heterofermentation|heterofermentative lactate fermentation|heterofermentative pathway|heterolactate fermentation|heterolactic fermentation http://purl.obolibrary.org/obo/GO_0019656 GO:0019657 biolink:BiologicalProcess glycolytic fermentation to propionate Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate. MetaCyc:P108-PWY go.json succinate-propionate fermentation http://purl.obolibrary.org/obo/GO_0019657 RO:0002007 biolink:OntologyClass bounding layer of RO:0002007 go.json http://purl.obolibrary.org/obo/RO_0002007 GO:0019654 biolink:BiologicalProcess acetate fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP. MetaCyc:P142-PWY go.json http://purl.obolibrary.org/obo/GO_0019654 GO:0019655 biolink:BiologicalProcess glycolytic fermentation to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. Wikipedia:Ethanol_fermentation go.json alcoholic fermentation|ethanol anabolism during fermentation|ethanol biosynthetic process involved in glucose fermentation to ethanol|ethanol fermentation|ethanol formation during fermentation|ethanol synthesis during fermentation|glucose catabolic process to ethanol|glucose fermentation to ethanol http://purl.obolibrary.org/obo/GO_0019655 GO:0019652 biolink:BiologicalProcess lactate fermentation to propionate and acetate The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP). MetaCyc:PROPFERM-PWY go.json acrylate pathway|nonrandomizing pathway|propionate fermentation http://purl.obolibrary.org/obo/GO_0019652 GO:0019653 biolink:BiologicalProcess anaerobic purine nucleobase catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP. MetaCyc:P164-PWY|MetaCyc:PWY-5044|MetaCyc:PWY-5497 go.json anaerobic purine base catabolic process|anaerobic purine base catabolism|anaerobic purine catabolic process|purine base fermentation|purine fermentation http://purl.obolibrary.org/obo/GO_0019653 GO:0019650 biolink:BiologicalProcess glycolytic fermentation to butanediol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia. MetaCyc:P125-PWY|Wikipedia:Butanediol_fermentation go.json butanediol fermentation|glucose catabolic process to butanediol|glucose fermentation to butanediol http://purl.obolibrary.org/obo/GO_0019650 GO:0019651 biolink:BiologicalProcess citrate catabolic process to diacetyl The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP. go.json citrate fermentation to diacetyl|diacetyl fermentation http://purl.obolibrary.org/obo/GO_0019651 GO:0005028 biolink:MolecularActivity obsolete CD40 receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json CD40 receptor activity True http://purl.obolibrary.org/obo/GO_0005028 GO:0005029 biolink:MolecularActivity obsolete CD27 receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json CD27 receptor activity True http://purl.obolibrary.org/obo/GO_0005029 GO:0005026 biolink:MolecularActivity transforming growth factor beta receptor activity, type II Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. Reactome:R-HSA-170843 go.json transforming growth factor beta ligand binding to type II receptor|type II TGF-beta receptor activity|type II TGFbeta receptor activity|type II transforming growth factor beta receptor activity http://purl.obolibrary.org/obo/GO_0005026 GO:0005027 biolink:MolecularActivity obsolete NGF/TNF (6 C-domain) receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json NGF/TNF (6 C-domain) receptor activity True http://purl.obolibrary.org/obo/GO_0005027 GO:0005024 biolink:MolecularActivity transforming growth factor beta receptor activity Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. go.json TGF-beta receptor activity|TGFbeta receptor activity|TGFbeta-activated receptor activity|TGFbetaR|transforming growth factor beta-activated receptor activity http://purl.obolibrary.org/obo/GO_0005024 GO:0005025 biolink:MolecularActivity transforming growth factor beta receptor activity, type I Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. go.json transforming growth factor beta ligand binding to type I receptor|type I TGF-beta receptor activity|type I TGFbeta receptor activity|type I transforming growth factor beta receptor activity http://purl.obolibrary.org/obo/GO_0005025 GO:0005023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005023 GO:0005020 biolink:MolecularActivity stem cell factor receptor activity Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. go.json KIT|KIT ligand receptor activity|KL receptor activity|SCF receptor activity http://purl.obolibrary.org/obo/GO_0005020 GO:0005021 biolink:MolecularActivity vascular endothelial growth factor receptor activity Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json VEGF receptor activity|VEGF-A-activated receptor activity|VEGF-B-activated receptor activity|VEGF-C-activated receptor activity|VEGF-D-activated receptor activity|VEGF-E-activated receptor activity|VEGF-activated receptor activity|VEGFR activity|vascular endothelial growth factor E-activated receptor activity|vascular endothelial growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0005021 GO:0019669 biolink:BiologicalProcess anaerobic glycine catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP. go.json glycine fermentation http://purl.obolibrary.org/obo/GO_0019669 GO:0019667 biolink:BiologicalProcess anaerobic L-alanine catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP. go.json L-alanine fermentation http://purl.obolibrary.org/obo/GO_0019667 GO:0019668 biolink:BiologicalProcess anaerobic catabolism of pairs of amino acids The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP. go.json Stickland reaction|cofermentation of pairs of amino acids http://purl.obolibrary.org/obo/GO_0019668 GO:0019665 biolink:BiologicalProcess anaerobic amino acid catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP. go.json amino acid fermentation http://purl.obolibrary.org/obo/GO_0019665 GO:0019666 biolink:BiologicalProcess nitrogenous compound fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP. go.json nitrogenous compound catabolic process http://purl.obolibrary.org/obo/GO_0019666 GO:0019663 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019663 GO:0019664 biolink:BiologicalProcess mixed acid fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP. Wikipedia:Mixed_acid_fermentation go.json glucose catabolic process to mixed acids|glucose fermentation to mixed acids http://purl.obolibrary.org/obo/GO_0019664 GO:0019661 biolink:BiologicalProcess glucose catabolic process to lactate via pyruvate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP). MetaCyc:ANAEROFRUCAT-PWY go.json glucose fermentation to lactate via pyruvate|homofermentation|homofermentative lactate fermentation|homofermentative pathway|homolactate fermentation|homolactic fermentation http://purl.obolibrary.org/obo/GO_0019661 GO:0019662 biolink:BiologicalProcess non-glycolytic fermentation Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. go.json http://purl.obolibrary.org/obo/GO_0019662 GO:0019660 biolink:BiologicalProcess glycolytic fermentation Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. MetaCyc:Pyruvate-Degradation go.json http://purl.obolibrary.org/obo/GO_0019660 GO:0019638 biolink:BiologicalProcess 6-hydroxycineole metabolic process The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. go.json 6-endo-hydroxycineole metabolic process|6-endo-hydroxycineole metabolism|6-hydroxycineole metabolism|hydroxycineol metabolic process|hydroxycineol metabolism http://purl.obolibrary.org/obo/GO_0019638 GO:0019639 biolink:BiologicalProcess 6-hydroxycineole catabolic process The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY go.json 6-endo-hydroxycineole catabolic process|6-endo-hydroxycineole catabolism|6-hydroxycineole breakdown|6-hydroxycineole catabolism|6-hydroxycineole degradation|hydroxycineol catabolic process|hydroxycineol catabolism http://purl.obolibrary.org/obo/GO_0019639 GO:0019636 biolink:BiologicalProcess phosphonoacetate metabolic process The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue. MetaCyc:P483-PWY go.json phosphonoacetate metabolism http://purl.obolibrary.org/obo/GO_0019636 GO:0019637 biolink:BiologicalProcess organophosphate metabolic process The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. go.json organophosphate metabolism http://purl.obolibrary.org/obo/GO_0019637 GO:0019634 biolink:BiologicalProcess organic phosphonate metabolic process The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. go.json organophosphonate metabolic process|phosphonate metabolism http://purl.obolibrary.org/obo/GO_0019634 GO:0019635 biolink:BiologicalProcess 2-aminoethylphosphonate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine. MetaCyc:PHOSPHONOTASE-PWY go.json 2-aminoethylphosphonate breakdown|2-aminoethylphosphonate catabolism|2-aminoethylphosphonate degradation|2-phosphonoethylamine catabolic process|2-phosphonoethylamine catabolism|ciliatine catabolic process|ciliatine catabolism http://purl.obolibrary.org/obo/GO_0019635 GO:0019632 biolink:BiologicalProcess shikimate metabolic process The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids. go.json shikimate metabolism http://purl.obolibrary.org/obo/GO_0019632 GO:0019633 biolink:BiologicalProcess shikimate catabolic process The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. MetaCyc:SHIKIMATEDEG-PWY go.json shikimate breakdown|shikimate catabolism|shikimate degradation http://purl.obolibrary.org/obo/GO_0019633 GO:0019630 biolink:BiologicalProcess quinate metabolic process The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine. go.json quinate metabolism|quinic acid metabolic process|quinic acid metabolism http://purl.obolibrary.org/obo/GO_0019630 GO:0019631 biolink:BiologicalProcess quinate catabolic process The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid. MetaCyc:QUINATEDEG-PWY go.json quinate breakdown|quinate catabolism|quinate degradation|quinic acid catabolic process|quinic acid catabolism http://purl.obolibrary.org/obo/GO_0019631 GO:0005008 biolink:MolecularActivity hepatocyte growth factor receptor activity Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json HGF receptor activity|HGF-activated receptor activity|hepatocyte growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0005008 GO:0005009 biolink:MolecularActivity insulin receptor activity Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. Reactome:R-HSA-74715 go.json insulin-activated receptor activity http://purl.obolibrary.org/obo/GO_0005009 GO:0005006 biolink:MolecularActivity epidermal growth factor receptor activity Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json EGF receptor activity|EGFR|TGF-alpha receptor activity|epidermal growth factor-activated receptor activity|transforming growth factor-alpha receptor activity http://purl.obolibrary.org/obo/GO_0005006 GO:0005007 biolink:MolecularActivity fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json FGF receptor activity|FGF-activated receptor activity|FGFR|fibroblast growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0005007 GO:0005004 biolink:MolecularActivity GPI-linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity. go.json GPI-linked Eph receptor activity http://purl.obolibrary.org/obo/GO_0005004 GO:0005005 biolink:MolecularActivity transmembrane-ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity. go.json transmembrane-Eph receptor activity http://purl.obolibrary.org/obo/GO_0005005 GO:0005003 biolink:MolecularActivity ephrin receptor activity Combining with an ephrin receptor ligand to initiate a change in cell activity. go.json Eph receptor activity http://purl.obolibrary.org/obo/GO_0005003 GO:0005000 biolink:MolecularActivity vasopressin receptor activity Combining with vasopressin to initiate a change in cell activity. go.json vasopressin activated calcium mobilizing receptor activity http://purl.obolibrary.org/obo/GO_0005000 GO:0005001 biolink:MolecularActivity transmembrane receptor protein tyrosine phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. go.json http://purl.obolibrary.org/obo/GO_0005001 GO:0019649 biolink:BiologicalProcess formaldehyde assimilation The pathways in which formaldehyde is processed and used as a carbon source for the cell. go.json http://purl.obolibrary.org/obo/GO_0019649 GO:0019647 biolink:BiologicalProcess formaldehyde assimilation via ribulose monophosphate cycle The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde. MetaCyc:PWY-1861 go.json formaldehyde assimilation via RuMP cycle|ribulose monophosphate cycle http://purl.obolibrary.org/obo/GO_0019647 GO:0019648 biolink:BiologicalProcess formaldehyde assimilation via xylulose monophosphate cycle The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds. MetaCyc:P185-PWY go.json formaldehyde assimilation via xylulose-5-phosphate cycle|formaldehyde fixation cycle http://purl.obolibrary.org/obo/GO_0019648 GO:0019645 biolink:BiologicalProcess anaerobic electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient. go.json http://purl.obolibrary.org/obo/GO_0019645 GO:0019646 biolink:BiologicalProcess aerobic electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient. go.json NADH-O2 electron transport|succinate-O2 electron transport|ubiquinone-8-O2 electron transport http://purl.obolibrary.org/obo/GO_0019646 GO:0019643 biolink:BiologicalProcess reductive tricarboxylic acid cycle A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate. MetaCyc:P23-PWY|MetaCyc:REDCITCYC go.json reductive Kreb's cycle|reductive TCA cycle|reductive carboxylate cycle|reductive carboxylic acid cycle|reductive citric acid pathway http://purl.obolibrary.org/obo/GO_0019643 GO:0019644 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019644 GO:0019641 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019641 GO:0019642 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019642 GO:0019640 biolink:BiologicalProcess glucuronate catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate. go.json glucuronate breakdown to xylulose 5-phosphate|glucuronate degradation to xylulose 5-phosphate http://purl.obolibrary.org/obo/GO_0019640 GO:0030093 biolink:CellularComponent chloroplast photosystem I Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0030093 GO:0030094 biolink:CellularComponent plasma membrane-derived photosystem I A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species. go.json plasma membrane photosystem I http://purl.obolibrary.org/obo/GO_0030094 GO:0030091 biolink:BiologicalProcess protein repair The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. go.json http://purl.obolibrary.org/obo/GO_0030091 GO:0030092 biolink:BiologicalProcess obsolete regulation of flagellum assembly OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum. go.json regulation of flagella assembly|regulation of flagella biogenesis|regulation of flagellum assembly|regulation of flagellum biogenesis True http://purl.obolibrary.org/obo/GO_0030092 GO:0030090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030090 GO:0030099 biolink:BiologicalProcess myeloid cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. go.json http://purl.obolibrary.org/obo/GO_0030099 GO:0030097 biolink:BiologicalProcess hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. Wikipedia:Haematopoiesis go.json blood cell biosynthesis|blood cell formation|haemopoiesis|hematopoiesis http://purl.obolibrary.org/obo/GO_0030097 GO:0030098 biolink:BiologicalProcess lymphocyte differentiation The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. go.json lymphocyte cell differentiation|lymphocyte development|lymphocytic blood cell differentiation http://purl.obolibrary.org/obo/GO_0030098 GO:0030095 biolink:CellularComponent chloroplast photosystem II An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. go.json http://purl.obolibrary.org/obo/GO_0030095 GO:0030096 biolink:CellularComponent plasma membrane-derived thylakoid photosystem II A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. go.json plasma membrane photosystem II http://purl.obolibrary.org/obo/GO_0030096 GO:0030082 biolink:CellularComponent B800-850 antenna complex Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. go.json LH2 complex|light harvesting complex II http://purl.obolibrary.org/obo/GO_0030082 GO:0030083 biolink:CellularComponent PSI associated light-harvesting complex I, LHCIa subcomplex A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm. go.json http://purl.obolibrary.org/obo/GO_0030083 GO:0030080 biolink:CellularComponent B875 antenna complex Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm. go.json LH1 complex|light harvesting complex I http://purl.obolibrary.org/obo/GO_0030080 GO:0030081 biolink:CellularComponent B800-820 antenna complex Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. go.json LH3 complex|light harvesting complex III http://purl.obolibrary.org/obo/GO_0030081 GO:0030088 biolink:CellularComponent obsolete PSII associated light-harvesting complex II, core complex, LHCIId subcomplex OBSOLETE. (Was not defined before being made obsolete). go.json PSII associated light-harvesting complex II, core complex, LHCIId subcomplex True http://purl.obolibrary.org/obo/GO_0030088 GO:0030089 biolink:CellularComponent phycobilisome Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II. Wikipedia:Phycobilisome go.json http://purl.obolibrary.org/obo/GO_0030089 GO:0030086 biolink:CellularComponent obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex OBSOLETE. (Was not defined before being made obsolete). go.json PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex True http://purl.obolibrary.org/obo/GO_0030086 GO:0030087 biolink:CellularComponent obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex OBSOLETE. (Was not defined before being made obsolete). go.json PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex True http://purl.obolibrary.org/obo/GO_0030087 GO:0030084 biolink:CellularComponent PSI associated light-harvesting complex I, LHCIb subcomplex A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm. go.json http://purl.obolibrary.org/obo/GO_0030084 GO:0030085 biolink:CellularComponent PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides. go.json http://purl.obolibrary.org/obo/GO_0030085 GO:0044600 biolink:MolecularActivity protein guanylyltransferase activity Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins. Reactome:R-HSA-9765952 go.json http://purl.obolibrary.org/obo/GO_0044600 GO:0044607 biolink:BiologicalProcess obsolete disruption by symbiont of host endothelial cells OBSOLETE. Any process in which an organism has a negative effect on the functioning of the host's endothelial cells. go.json True http://purl.obolibrary.org/obo/GO_0044607 GO:0030071 biolink:BiologicalProcess regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. go.json http://purl.obolibrary.org/obo/GO_0030071 GO:0044608 biolink:BiologicalProcess obsolete peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine OBSOLETE. The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester. go.json peptidyl-threonine esterification True http://purl.obolibrary.org/obo/GO_0044608 GO:0030072 biolink:BiologicalProcess peptide hormone secretion The regulated release of a peptide hormone from a cell. go.json http://purl.obolibrary.org/obo/GO_0030072 GO:0044605 biolink:MolecularActivity phosphocholine transferase activity Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate. go.json http://purl.obolibrary.org/obo/GO_0044605 GO:0044606 biolink:MolecularActivity phosphocholine hydrolase activity Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate. go.json http://purl.obolibrary.org/obo/GO_0044606 GO:0030070 biolink:BiologicalProcess insulin processing The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges. go.json http://purl.obolibrary.org/obo/GO_0030070 GO:0044603 biolink:MolecularActivity protein adenylylhydrolase activity Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins. go.json protein deAMPylase activity|protein deAMPylation activity http://purl.obolibrary.org/obo/GO_0044603 GO:0044604 biolink:MolecularActivity ABC-type phytochelatin transporter activity Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. go.json ABC-type phytochelatin transmembrane transporter activity|ATP-dependent phytochelatin transmembrane transporter activity|ATPase-coupled phytochelatin transmembrane transporter activity|cadystin transmembrane transporter ATPase activity|cadystin transmembrane transporter activity|cadystin transporter activity|phytochelatin transmembrane transporter ATPase activity|phytochelatin transmembrane transporter activity|phytochelatin transporter activity http://purl.obolibrary.org/obo/GO_0044604 GO:0044601 biolink:BiologicalProcess protein denucleotidylation The removal of a nucleotide from a protein amino acid. go.json http://purl.obolibrary.org/obo/GO_0044601 gocheck_do_not_annotate GO:0044602 biolink:BiologicalProcess protein deadenylylation The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid. go.json protein deAMPylation http://purl.obolibrary.org/obo/GO_0044602 gocheck_do_not_annotate GO:0030079 biolink:CellularComponent light-harvesting complex, peripheral complex Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center. go.json http://purl.obolibrary.org/obo/GO_0030079 GO:0030077 biolink:CellularComponent plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. go.json http://purl.obolibrary.org/obo/GO_0030077 GO:0030078 biolink:CellularComponent light-harvesting complex, core complex Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria. go.json http://purl.obolibrary.org/obo/GO_0030078 GO:0030075 biolink:CellularComponent bacterial thylakoid A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria. go.json plasma membrane-derived thylakoid http://purl.obolibrary.org/obo/GO_0030075 GO:0030076 biolink:CellularComponent light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Wikipedia:Light-harvesting_complex go.json antenna complex http://purl.obolibrary.org/obo/GO_0030076 goslim_pir GO:0044609 biolink:CellularComponent DBIRD complex A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD. go.json http://purl.obolibrary.org/obo/GO_0044609 GO:0030073 biolink:BiologicalProcess insulin secretion The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. go.json http://purl.obolibrary.org/obo/GO_0030073 GO:0030074 biolink:CellularComponent obsolete thylakoid (sensu Proteobacteria) OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224). go.json thylakoid (sensu Proteobacteria) True http://purl.obolibrary.org/obo/GO_0030074 GO:0044610 biolink:MolecularActivity FMN transmembrane transporter activity Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other. go.json flavine mononucleotide transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0044610 GO:0044611 biolink:CellularComponent nuclear pore inner ring A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex. go.json Nup170 complex http://purl.obolibrary.org/obo/GO_0044611 GO:0030060 biolink:MolecularActivity L-malate dehydrogenase activity Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. EC:1.1.1.37|MetaCyc:MALATE-DEH-RXN|RHEA:21432|Reactome:R-HSA-198508|Reactome:R-HSA-70979|Reactome:R-HSA-71783 go.json (S)-malate:NAD+ oxidoreductase activity|L-malate-NAD+ oxidoreductase activity|MDH|NAD-L-malate dehydrogenase activity|NAD-dependent malate dehydrogenase activity|NAD-dependent malic dehydrogenase activity|NAD-linked malate dehydrogenase activity|NAD-malate dehydrogenase activity|NAD-malic dehydrogenase activity|NAD-specific malate dehydrogenase activity|malate (NAD) dehydrogenase activity|malic acid dehydrogenase activity|malic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0030060 GO:0044618 biolink:BiologicalProcess modulation of relaxation of uterine smooth muscle in another organism The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism. go.json modulation of relaxation of uterine smooth muscle in other organism|regulation of relaxation of uterine smooth muscle in other organism http://purl.obolibrary.org/obo/GO_0044618 GO:0044619 biolink:BiologicalProcess positive regulation of relaxation of uterine smooth muscle in another organism The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism. go.json positive regulation of relaxation of uterine smooth muscle in other organism http://purl.obolibrary.org/obo/GO_0044619 GO:0030061 biolink:CellularComponent mitochondrial crista Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. NIF_Subcellular:sao333328131 go.json cristae|mitochondrial cristae http://purl.obolibrary.org/obo/GO_0030061 GO:0044616 biolink:BiologicalProcess modulation of relaxation of muscle in another organism The process in which an organism effects a change in the relaxation of muscle in a second organism. go.json modulation of relaxation of muscle in other organism|regulation of relaxation of muscle in other organism http://purl.obolibrary.org/obo/GO_0044616 GO:0044617 biolink:BiologicalProcess modulation of relaxation of smooth muscle in another organism The process in which an organism effects a change in the relaxation of smooth muscle in a second organism. go.json modulation of relaxation of smooth muscle in other organism|regulation of relaxation of smooth muscle in other organism http://purl.obolibrary.org/obo/GO_0044617 GO:0044614 biolink:CellularComponent nuclear pore cytoplasmic filaments Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component. go.json cytoplasmic fibers of the NPC|cytoplasmic fibers of the nuclear pore complex http://purl.obolibrary.org/obo/GO_0044614 GO:0044615 biolink:CellularComponent nuclear pore nuclear basket A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component. go.json http://purl.obolibrary.org/obo/GO_0044615 GO:0044612 biolink:CellularComponent nuclear pore linkers A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p). go.json Nic96 complex|Nup82 complex http://purl.obolibrary.org/obo/GO_0044612 GO:0044613 biolink:CellularComponent nuclear pore central transport channel The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153. go.json karyopherin docking complex|nuclear pore central channel|nuclear pore central plug|nuclear pore transport channel http://purl.obolibrary.org/obo/GO_0044613 GO:0030068 biolink:BiologicalProcess obsolete lytic viral life cycle OBSOLETE. (Was not defined before being made obsolete). go.json lytic viral life cycle True http://purl.obolibrary.org/obo/GO_0030068 GO:0030069 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030069 GO:0030066 biolink:MolecularActivity obsolete cytochrome b6 OBSOLETE. (Was not defined before being made obsolete). go.json cytochrome b-563|cytochrome b6 True http://purl.obolibrary.org/obo/GO_0030066 GO:0030067 biolink:MolecularActivity obsolete respiratory chain cytochrome b6 OBSOLETE. (Was not defined before being made obsolete). go.json respiratory chain cytochrome b6 True http://purl.obolibrary.org/obo/GO_0030067 GO:0030064 biolink:CellularComponent obsolete cell wall inner membrane OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria. go.json cell wall inner membrane True http://purl.obolibrary.org/obo/GO_0030064 GO:0030065 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030065 GO:0030062 biolink:CellularComponent mitochondrial tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle. go.json TCA cycle enzyme complex http://purl.obolibrary.org/obo/GO_0030062 GO:0030063 biolink:CellularComponent obsolete murein sacculus OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall. go.json murein sacculus|peptidoglycan layer True http://purl.obolibrary.org/obo/GO_0030063 GO:0030059 biolink:MolecularActivity aralkylamine dehydrogenase (azurin) activity Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]. EC:1.4.9.2|MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN|RHEA:47796 go.json aralkylamine:(azurin) oxidoreductase (deaminating) activity|aromatic amine dehydrogenase (azurin) activity http://purl.obolibrary.org/obo/GO_0030059 GO:0044621 biolink:BiologicalProcess modulation of cell migration in another organism The process in which an organism effects a change in the process of cell migration in a second organism. go.json envenomation resulting in modulation of cell migration in another organism|envenomation resulting in modulation of cell migration in other organism|envenomation resulting in regulation of cell migration in other organism|modulation of cell migration in other organism|regulation of cell migration in other organism http://purl.obolibrary.org/obo/GO_0044621 GO:0044622 biolink:BiologicalProcess negative regulation of cell migration in another organism Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism. go.json envenomation resulting in negative regulation of cell migration in another organism|envenomation resulting in negative regulation of cell migration in other organism|negative regulation of cell migration in other organism http://purl.obolibrary.org/obo/GO_0044622 GO:0005099 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005099 GO:0044620 biolink:MolecularActivity ACP phosphopantetheine attachment site binding Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP). go.json http://purl.obolibrary.org/obo/GO_0044620 GO:0005097 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005097 GO:0005098 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005098 GO:0005095 biolink:MolecularActivity GTPase inhibitor activity Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. go.json GIP http://purl.obolibrary.org/obo/GO_0005095 GO:0005096 biolink:MolecularActivity GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. Reactome:R-HSA-392513|Reactome:R-HSA-399935|Reactome:R-HSA-4093339|Reactome:R-HSA-416546|Reactome:R-HSA-416559|Reactome:R-HSA-428522|Reactome:R-HSA-428533|Reactome:R-HSA-5638007|Reactome:R-HSA-8981637|Reactome:R-HSA-8985594|Reactome:R-HSA-9013022|Reactome:R-HSA-9013111|Reactome:R-HSA-9013144|Reactome:R-HSA-9013161|Reactome:R-HSA-9013437|Reactome:R-HSA-9014295|Reactome:R-HSA-9014434|Reactome:R-HSA-9017488|Reactome:R-HSA-9018745|Reactome:R-HSA-9018806|Reactome:R-HSA-9624893|Reactome:R-HSA-9693282 go.json ARF GAP activity|ARF GTPase activator activity|GAP activity|Rab GAP activity|Rab GTPase activator activity|Rac GAP activity|Rac GTPase activator activity|Ral GAP activity|Ral GTPase activator activity|Ran GAP activity|Ran GTPase activator activity|RanGAP|Rap GAP activity|Rap GTPase activator activity|Ras GAP activity|Ras GTPase activator activity|Rho GAP activity|Rho GTPase activator activity|Sar GAP activity|Sar GTPase activator activity http://purl.obolibrary.org/obo/GO_0005096 GO:0044629 biolink:BiologicalProcess negative regulation of complement activation, classical pathway in another organism Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism. go.json negative regulation of complement activation, classical pathway in other organism http://purl.obolibrary.org/obo/GO_0044629 GO:0030050 biolink:BiologicalProcess vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_0030050 GO:0044627 biolink:BiologicalProcess modulation of complement activation, classical pathway in another organism A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism. go.json modulation of complement activation, classical pathway in other organism|regulation of complement activation, classical pathway in other organism http://purl.obolibrary.org/obo/GO_0044627 GO:0044628 biolink:BiologicalProcess positive regulation of complement activation, classical pathway in another organism Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism. go.json positive regulation of complement activation, classical pathway in other organism http://purl.obolibrary.org/obo/GO_0044628 GO:0044625 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044625 GO:0044626 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044626 GO:0044623 biolink:BiologicalProcess positive regulation of cell migration in another organism Any process that activates or increases the frequency, rate or extent of cell migration in a second organism. go.json envenomation resulting in positive regulation of cell migration in another organism|envenomation resulting in positive regulation of cell migration in other organism|positive regulation of cell migration in other organism http://purl.obolibrary.org/obo/GO_0044623 GO:0044624 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044624 GO:0030057 biolink:CellularComponent desmosome A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. Wikipedia:Desmosome go.json macula adherens|spot desmosome http://purl.obolibrary.org/obo/GO_0030057 GO:0030058 biolink:MolecularActivity amine dehydrogenase activity Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+. RHEA:51128|UM-BBD_enzymeID:e0058 go.json MADH activity|amine: (acceptor) oxidoreductase (deaminating)|methylamine dehydrogenase activity|primary-amine dehydrogenase activity|primary-amine:acceptor oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0030058 GO:0030055 biolink:CellularComponent cell-substrate junction A cell junction that forms a connection between a cell and the extracellular matrix. go.json cell-matrix junction http://purl.obolibrary.org/obo/GO_0030055 GO:0030056 biolink:CellularComponent hemidesmosome A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces. Wikipedia:Hemidesmosome go.json epidermal attachment structure|fibrous organelle|hemi-adherens junction|trans-epithelial attachment http://purl.obolibrary.org/obo/GO_0030056 GO:0030053 biolink:MolecularActivity obsolete immunophilin OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin. go.json immunophilin True http://purl.obolibrary.org/obo/GO_0030053 GO:0030054 biolink:CellularComponent cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. Wikipedia:Cell_junction go.json http://purl.obolibrary.org/obo/GO_0030054 goslim_agr|goslim_drosophila|goslim_flybase_ribbon GO:0030051 biolink:MolecularActivity obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0)). go.json FK506 binding protein|FK506-sensitive peptidyl-prolyl cis-trans isomerase|FKBP True http://purl.obolibrary.org/obo/GO_0030051 GO:0030052 biolink:MolecularActivity obsolete parvulin OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin. go.json parvulin True http://purl.obolibrary.org/obo/GO_0030052 GO:0030048 biolink:BiologicalProcess actin filament-based movement Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. go.json http://purl.obolibrary.org/obo/GO_0030048 GO:0030049 biolink:BiologicalProcess muscle filament sliding The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. go.json http://purl.obolibrary.org/obo/GO_0030049 GO:0044632 biolink:BiologicalProcess negative regulation of complement activation, lectin pathway in another organism Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism. go.json negative regulation of complement activation, lectin pathway in other organism http://purl.obolibrary.org/obo/GO_0044632 GO:0044633 biolink:BiologicalProcess modulation of complement activation, alternative pathway in another organism A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism. go.json modulation of complement activation, alternative pathway in other organism|regulation of complement activation, alternative pathway in other organism http://purl.obolibrary.org/obo/GO_0044633 GO:0044630 biolink:BiologicalProcess modulation of complement activation, lectin pathway in another organism A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism. go.json modulation of complement activation, lectin pathway in other organism|regulation of complement activation, lectin pathway in other organism http://purl.obolibrary.org/obo/GO_0044630 GO:0044631 biolink:BiologicalProcess positive regulation of complement activation, lectin pathway in another organism Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism. go.json positive regulation of complement activation, lectin pathway in other organism http://purl.obolibrary.org/obo/GO_0044631 GO:0044638 biolink:BiologicalProcess envenomation resulting in positive regulation of complement activation, classical pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism. go.json envenomation resulting in positive regulation of complement activation, classical pathway in other organism http://purl.obolibrary.org/obo/GO_0044638 GO:0044639 biolink:BiologicalProcess envenomation resulting in modulation of complement activation, lectin pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism. go.json envenomation resulting in modulation of complement activation, lectin pathway in other organism|envenomation resulting in regulation of complement activation, lectin pathway in other organism http://purl.obolibrary.org/obo/GO_0044639 GO:0044636 biolink:BiologicalProcess envenomation resulting in modulation of complement activation, classical pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism. go.json envenomation resulting in modulation of complement activation, classical pathway in other organism http://purl.obolibrary.org/obo/GO_0044636 GO:0044637 biolink:BiologicalProcess envenomation resulting in negative regulation of complement activation, classical pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism. go.json envenomation resulting in negative regulation of complement activation, classical pathway in other organism http://purl.obolibrary.org/obo/GO_0044637 GO:0044634 biolink:BiologicalProcess negative regulation of complement activation, alternative pathway in another organism Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. go.json negative regulation of complement activation, alternative pathway in other organism http://purl.obolibrary.org/obo/GO_0044634 GO:0044635 biolink:BiologicalProcess positive regulation of complement activation, alternative pathway in another organism Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. go.json positive regulation of complement activation, alternative pathway in other organism http://purl.obolibrary.org/obo/GO_0044635 GO:0030046 biolink:BiologicalProcess parallel actin filament bundle assembly Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. go.json http://purl.obolibrary.org/obo/GO_0030046 GO:0030047 biolink:BiologicalProcess actin modification Covalent modification of an actin molecule. go.json http://purl.obolibrary.org/obo/GO_0030047 gocheck_do_not_annotate GO:0030044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030044 GO:0030045 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030045 GO:0030042 biolink:BiologicalProcess actin filament depolymerization Disassembly of actin filaments by the removal of actin monomers from a filament. go.json actin depolymerization|actin depolymerizing activity http://purl.obolibrary.org/obo/GO_0030042 GO:0030043 biolink:BiologicalProcess actin filament fragmentation The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins. go.json http://purl.obolibrary.org/obo/GO_0030043 GO:0030040 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030040 GO:0030041 biolink:BiologicalProcess actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament. go.json actin polymerization|actin polymerizing activity http://purl.obolibrary.org/obo/GO_0030041 GO:0030039 biolink:MolecularActivity obsolete DNA unwinding factor OBSOLETE. (Was not defined before being made obsolete). go.json DNA unwinding factor True http://purl.obolibrary.org/obo/GO_0030039 GO:0030037 biolink:BiologicalProcess obsolete actin filament reorganization involved in cell cycle OBSOLETE. The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs. go.json actin filament reorganisation involved in cell cycle|actin filament reorganization during cell cycle True http://purl.obolibrary.org/obo/GO_0030037 GO:0030038 biolink:BiologicalProcess contractile actin filament bundle assembly Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. go.json http://purl.obolibrary.org/obo/GO_0030038 GO:0005079 biolink:MolecularActivity obsolete protein kinase A anchoring activity OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location. go.json A-kinase anchor protein activity|AKAP activity|protein kinase A anchoring activity True http://purl.obolibrary.org/obo/GO_0005079 GO:0044643 biolink:BiologicalProcess envenomation resulting in positive regulation of complement activation, alternative pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism. go.json envenomation resulting in positive regulation of complement activation, alternative pathway in other organism http://purl.obolibrary.org/obo/GO_0044643 GO:0044644 biolink:BiologicalProcess envenomation resulting in negative regulation of complement activation, alternative pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism. go.json envenomation resulting in negative regulation of complement activation, alternative pathway in other organism http://purl.obolibrary.org/obo/GO_0044644 GO:0005077 biolink:MolecularActivity obsolete MAP-kinase anchoring activity OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location. go.json MAP-kinase anchor protein activity|MAP-kinase anchoring activity True http://purl.obolibrary.org/obo/GO_0005077 GO:0044641 biolink:BiologicalProcess envenomation resulting in positive regulation of complement activation, lectin pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism. go.json envenomation resulting in positive regulation of complement activation, lectin pathway in other organism http://purl.obolibrary.org/obo/GO_0044641 GO:0005078 biolink:MolecularActivity MAP-kinase scaffold activity The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. go.json MAP-kinase scaffold protein activity http://purl.obolibrary.org/obo/GO_0005078 GO:0044642 biolink:BiologicalProcess envenomation resulting in modulation of complement activation, alternative pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism. go.json envenomation resulting in modulation of complement activation, alternative pathway in other organism|envenomation resulting in regulation of complement activation, alternative pathway in other organism http://purl.obolibrary.org/obo/GO_0044642 GO:0005075 biolink:MolecularActivity obsolete pathway-specific SMAD protein OBSOLETE. (Was not defined before being made obsolete). go.json pathway-specific SMAD protein True http://purl.obolibrary.org/obo/GO_0005075 GO:0044640 biolink:BiologicalProcess envenomation resulting in negative regulation of complement activation, lectin pathway in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism. go.json envenomation resulting in negative regulation of complement activation, lectin pathway in other organism http://purl.obolibrary.org/obo/GO_0044640 GO:0005076 biolink:MolecularActivity obsolete receptor signaling protein serine/threonine kinase signaling protein activity OBSOLETE. (Was not defined before being made obsolete). go.json receptor signaling protein serine/threonine kinase signaling protein activity|receptor signalling protein serine/threonine kinase signalling protein activity True http://purl.obolibrary.org/obo/GO_0005076 GO:0005073 biolink:MolecularActivity obsolete common-partner SMAD protein OBSOLETE. (Was not defined before being made obsolete). go.json common-partner SMAD protein True http://purl.obolibrary.org/obo/GO_0005073 GO:0005074 biolink:MolecularActivity obsolete inhibitory SMAD protein OBSOLETE. (Was not defined before being made obsolete). go.json inhibitory SMAD protein True http://purl.obolibrary.org/obo/GO_0005074 GO:0005082 biolink:MolecularActivity obsolete receptor signaling protein tyrosine phosphatase signaling protein activity OBSOLETE. (Was not defined before being made obsolete). go.json receptor signaling protein tyrosine phosphatase signaling protein activity|receptor signalling protein tyrosine phosphatase signalling protein activity True http://purl.obolibrary.org/obo/GO_0005082 GO:0005083 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005083 GO:0005080 biolink:MolecularActivity protein kinase C binding Binding to protein kinase C. go.json PKC alpha binding|PKC binding|PKC delta binding|PKC eta binding|protein kinase C alpha binding|protein kinase C delta binding|protein kinase C eta binding http://purl.obolibrary.org/obo/GO_0005080 GO:0044649 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044649 GO:0005081 biolink:MolecularActivity obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity OBSOLETE. (Was not defined before being made obsolete). go.json receptor signaling protein serine/threonine phosphatase signaling protein activity|receptor signalling protein serine/threonine phosphatase signalling protein activity True http://purl.obolibrary.org/obo/GO_0005081 GO:0044647 biolink:CellularComponent host-symbiont bicellular tight junction An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane. go.json host-parasite tight junction|host-pathogen tight junction http://purl.obolibrary.org/obo/GO_0044647 GO:0044648 biolink:BiologicalProcess histone H3-K4 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone. go.json http://purl.obolibrary.org/obo/GO_0044648 gocheck_do_not_annotate GO:0044645 biolink:BiologicalProcess modulation of complement activation in another organism A process that modulates the frequency, rate or extent of complement activation in a different organism. go.json modulation of complement activation in other organism|regulation of complement activation in other organism http://purl.obolibrary.org/obo/GO_0044645 GO:0044646 biolink:BiologicalProcess envenomation resulting in modulation of complement activation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism. go.json envenomation resulting in modulation of complement activation in other organism|envenomation resulting in regulation of complement activation in other organism http://purl.obolibrary.org/obo/GO_0044646 GO:0030035 biolink:BiologicalProcess microspike assembly Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell. go.json microspike biogenesis|microspike biosynthesis|microspike formation http://purl.obolibrary.org/obo/GO_0030035 GO:0030036 biolink:BiologicalProcess actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. go.json actin cytoskeleton organisation|actin cytoskeleton organization and biogenesis|actin modulating activity http://purl.obolibrary.org/obo/GO_0030036 goslim_pombe GO:0030033 biolink:BiologicalProcess microvillus assembly Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. go.json microvillus biogenesis http://purl.obolibrary.org/obo/GO_0030033 GO:0030034 biolink:BiologicalProcess microvillar actin bundle assembly Assembly of the parallel bundle of actin filaments at the core of a microvillus. go.json http://purl.obolibrary.org/obo/GO_0030034 GO:0030031 biolink:BiologicalProcess cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. go.json cell projection biogenesis|formation of a cell surface projection http://purl.obolibrary.org/obo/GO_0030031 GO:0030032 biolink:BiologicalProcess lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. go.json lamellipodium biogenesis|lamellipodium biosynthesis|lamellipodium formation http://purl.obolibrary.org/obo/GO_0030032 GO:0030030 biolink:BiologicalProcess cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. go.json cell projection organisation|cell projection organization and biogenesis|cell surface structure organization and biogenesis http://purl.obolibrary.org/obo/GO_0030030 prokaryote_subset GO:0030028 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030028 GO:0030029 biolink:BiologicalProcess actin filament-based process Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. go.json microfilament-based process http://purl.obolibrary.org/obo/GO_0030029 GO:0030026 biolink:BiologicalProcess intracellular manganese ion homeostasis A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell. go.json cellular manganese ion homeostasis|manganese homeostasis http://purl.obolibrary.org/obo/GO_0030026 GO:0030027 biolink:CellularComponent lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. Wikipedia:Lamellipodia go.json http://purl.obolibrary.org/obo/GO_0030027 GO:0044654 biolink:MolecularActivity starch alpha-glucosidase activity Catalysis of the reaction: starch + H2O = alpha-D-glucose. go.json http://purl.obolibrary.org/obo/GO_0044654 GO:0044655 biolink:BiologicalProcess phagosome reneutralization Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation. go.json phagosomal reneutralization|phagosome pH elevation http://purl.obolibrary.org/obo/GO_0044655 GO:0005088 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005088 GO:0044652 biolink:BiologicalProcess adhesion of symbiont to host endothelial cell The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. go.json http://purl.obolibrary.org/obo/GO_0044652 GO:0005089 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005089 GO:0044653 biolink:MolecularActivity dextrin alpha-glucosidase activity Catalysis of the reaction: dextrin + H2O = alpha-D-glucose. go.json http://purl.obolibrary.org/obo/GO_0044653 GO:0005086 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005086 GO:0044650 biolink:BiologicalProcess adhesion of symbiont to host cell The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly. go.json http://purl.obolibrary.org/obo/GO_0044650 GO:0005087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005087 GO:0044651 biolink:BiologicalProcess adhesion of symbiont to host epithelial cell The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. go.json http://purl.obolibrary.org/obo/GO_0044651 GO:0005084 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005084 GO:0005085 biolink:MolecularActivity guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. Reactome:R-HSA-109807|Reactome:R-HSA-109817|Reactome:R-HSA-114544|Reactome:R-HSA-1168636|Reactome:R-HSA-1225951|Reactome:R-HSA-1225957|Reactome:R-HSA-1250383|Reactome:R-HSA-1250463|Reactome:R-HSA-1250498|Reactome:R-HSA-1306972|Reactome:R-HSA-1433415|Reactome:R-HSA-1433471|Reactome:R-HSA-156913|Reactome:R-HSA-169904|Reactome:R-HSA-170979|Reactome:R-HSA-171026|Reactome:R-HSA-177938|Reactome:R-HSA-177945|Reactome:R-HSA-180687|Reactome:R-HSA-186834|Reactome:R-HSA-187746|Reactome:R-HSA-194518|Reactome:R-HSA-2029445|Reactome:R-HSA-2029451|Reactome:R-HSA-2029467|Reactome:R-HSA-203977|Reactome:R-HSA-205039|Reactome:R-HSA-210977|Reactome:R-HSA-2179407|Reactome:R-HSA-2424476|Reactome:R-HSA-2424477|Reactome:R-HSA-2485180|Reactome:R-HSA-2730840|Reactome:R-HSA-350769|Reactome:R-HSA-354173|Reactome:R-HSA-379044|Reactome:R-HSA-379048|Reactome:R-HSA-380073|Reactome:R-HSA-389348|Reactome:R-HSA-389350|Reactome:R-HSA-392054|Reactome:R-HSA-392195|Reactome:R-HSA-3928592|Reactome:R-HSA-3928612|Reactome:R-HSA-3928628|Reactome:R-HSA-3928632|Reactome:R-HSA-3928633|Reactome:R-HSA-3928642|Reactome:R-HSA-3928651|Reactome:R-HSA-392870|Reactome:R-HSA-3965444|Reactome:R-HSA-399938|Reactome:R-HSA-399995|Reactome:R-HSA-4093336|Reactome:R-HSA-416530|Reactome:R-HSA-416588|Reactome:R-HSA-418579|Reactome:R-HSA-418850|Reactome:R-HSA-418856|Reactome:R-HSA-419166|Reactome:R-HSA-420883|Reactome:R-HSA-428535|Reactome:R-HSA-428750|Reactome:R-HSA-428917|Reactome:R-HSA-442273|Reactome:R-HSA-442291|Reactome:R-HSA-442314|Reactome:R-HSA-442732|Reactome:R-HSA-445064|Reactome:R-HSA-5218829|Reactome:R-HSA-5218839|Reactome:R-HSA-5218850|Reactome:R-HSA-5617816|Reactome:R-HSA-5623508|Reactome:R-HSA-5623521|Reactome:R-HSA-5637806|Reactome:R-HSA-5637808|Reactome:R-HSA-5654392|Reactome:R-HSA-5654402|Reactome:R-HSA-5654413|Reactome:R-HSA-5654426|Reactome:R-HSA-5654600|Reactome:R-HSA-5654618|Reactome:R-HSA-5654647|Reactome:R-HSA-5654663|Reactome:R-HSA-5655241|Reactome:R-HSA-5655277|Reactome:R-HSA-5655326|Reactome:R-HSA-5655347|Reactome:R-HSA-5672965|Reactome:R-HSA-5686071|Reactome:R-HSA-5686318|Reactome:R-HSA-5694409|Reactome:R-HSA-6807868|Reactome:R-HSA-6811414|Reactome:R-HSA-6811418|Reactome:R-HSA-6811429|Reactome:R-HSA-749453|Reactome:R-HSA-751029|Reactome:R-HSA-825631|Reactome:R-HSA-8848618|Reactome:R-HSA-8850041|Reactome:R-HSA-8851827|Reactome:R-HSA-8851877|Reactome:R-HSA-8851899|Reactome:R-HSA-8875318|Reactome:R-HSA-8875320|Reactome:R-HSA-8875568|Reactome:R-HSA-8875591|Reactome:R-HSA-8876188|Reactome:R-HSA-8876190|Reactome:R-HSA-8876191|Reactome:R-HSA-8876193|Reactome:R-HSA-8876454|Reactome:R-HSA-8876615|Reactome:R-HSA-8876616|Reactome:R-HSA-8876837|Reactome:R-HSA-8877308|Reactome:R-HSA-8877311|Reactome:R-HSA-8877451|Reactome:R-HSA-8877475|Reactome:R-HSA-8877612|Reactome:R-HSA-8877760|Reactome:R-HSA-8877813|Reactome:R-HSA-8877998|Reactome:R-HSA-8964604|Reactome:R-HSA-8980691|Reactome:R-HSA-8982637|Reactome:R-HSA-8982640|Reactome:R-HSA-9013023|Reactome:R-HSA-9013109|Reactome:R-HSA-9013143|Reactome:R-HSA-9013159|Reactome:R-HSA-9013435|Reactome:R-HSA-9014296|Reactome:R-HSA-9014433|Reactome:R-HSA-9017491|Reactome:R-HSA-9018747|Reactome:R-HSA-9018768|Reactome:R-HSA-9018804|Reactome:R-HSA-9018817|Reactome:R-HSA-9018825|Reactome:R-HSA-9026891|Reactome:R-HSA-9029158|Reactome:R-HSA-9032067|Reactome:R-HSA-9032798|Reactome:R-HSA-9033292|Reactome:R-HSA-9036301|Reactome:R-HSA-939265|Reactome:R-HSA-9607304|Reactome:R-HSA-9619803|Reactome:R-HSA-9624845|Reactome:R-HSA-9634418|Reactome:R-HSA-9639286|Reactome:R-HSA-9640167|Reactome:R-HSA-9660824|Reactome:R-HSA-9664991|Reactome:R-HSA-9665009|Reactome:R-HSA-9665404|Reactome:R-HSA-9665408|Reactome:R-HSA-9665700|Reactome:R-HSA-9665707|Reactome:R-HSA-9666428|Reactome:R-HSA-9666430|Reactome:R-HSA-9670436|Reactome:R-HSA-9672163|Reactome:R-HSA-9672170|Reactome:R-HSA-9680385|Reactome:R-HSA-9693111|Reactome:R-HSA-9695853|Reactome:R-HSA-9703441|Reactome:R-HSA-9751201 go.json ARF guanyl-nucleotide exchange factor activity|GDP-dissociation stimulator activity|GDS|GEF|GNRP|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ral guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity|Rap guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|Rho guanine nucleotide exchange factor|Rho guanyl-nucleotide exchange factor activity|RhoGEF|Sar guanyl-nucleotide exchange factor activity|cAMP-dependent guanyl-nucleotide exchange factor activity|guanyl-nucleotide release factor activity|guanyl-nucleotide releasing factor http://purl.obolibrary.org/obo/GO_0005085 goslim_chembl|goslim_drosophila|goslim_yeast GO:0005093 biolink:MolecularActivity Rab GDP-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. go.json http://purl.obolibrary.org/obo/GO_0005093 GO:0005094 biolink:MolecularActivity Rho GDP-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. go.json http://purl.obolibrary.org/obo/GO_0005094 GO:0005091 biolink:MolecularActivity guanyl-nucleotide exchange factor adaptor activity The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. go.json http://purl.obolibrary.org/obo/GO_0005091 GO:0005092 biolink:MolecularActivity GDP-dissociation inhibitor activity Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. go.json GDI http://purl.obolibrary.org/obo/GO_0005092 GO:0044658 biolink:BiologicalProcess symbiont-mediated pore formation in host plasma membrane The disruption of host plasma membrane integrity by formation of a pore, resulting in deregulated ion homeostasis, and cellular dysfunction that can result in cell death. go.json pore formation in host plasma membrane|pore formation in membrane of host by symbiont http://purl.obolibrary.org/obo/GO_0044658 GO:0044659 biolink:BiologicalProcess viral release from host cell by cytolysis The dissemination of mature viral particles from a host cell by the rupture of cell membranes and the loss of cytoplasm. VZ:1077 go.json cytolysis by virus of host cell|lytic viral life cycle|lytic viral release|viral exit from host cell by cytolysis|viral release by cell lysis|viral release by host cell lysis http://purl.obolibrary.org/obo/GO_0044659 GO:0005090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005090 GO:0044656 biolink:BiologicalProcess regulation of post-lysosomal vacuole size Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. go.json regulation of post-lysosome size|regulation of postlysosomal vacuole size|regulation of postlysosome vacuole size http://purl.obolibrary.org/obo/GO_0044656 GO:0044657 biolink:BiologicalProcess obsolete pore formation in membrane of other organism during symbiotic interaction OBSOLETE. The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044657 GO:0030024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030024 GO:0030025 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030025 GO:0030022 biolink:MolecularActivity obsolete adhesive extracellular matrix constituent OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix. go.json adhesive extracellular matrix constituent True http://purl.obolibrary.org/obo/GO_0030022 GO:0030023 biolink:MolecularActivity extracellular matrix constituent conferring elasticity A component of the extracellular matrix that enables the matrix to recoil after transient stretching. go.json core extracellular matrix|core matrisome|elastin http://purl.obolibrary.org/obo/GO_0030023 GO:0030020 biolink:MolecularActivity extracellular matrix structural constituent conferring tensile strength A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. go.json core extracellular matrix|core matrisome http://purl.obolibrary.org/obo/GO_0030020 GO:0030021 biolink:MolecularActivity extracellular matrix structural constituent conferring compression resistance A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. go.json core extracellular matrix|core matrisome http://purl.obolibrary.org/obo/GO_0030021 GO:0019618 biolink:BiologicalProcess protocatechuate catabolic process, ortho-cleavage The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate. MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY go.json 3,4-dihydroxybenzoate catabolic process, ortho-cleavage|protocatechuate breakdown, ortho-cleavage|protocatechuate catabolic process to beta-ketoadipate|protocatechuate degradation, ortho-cleavage http://purl.obolibrary.org/obo/GO_0019618 GO:0019619 biolink:BiologicalProcess 3,4-dihydroxybenzoate catabolic process The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. go.json protocatechuate breakdown|protocatechuate catabolic process|protocatechuate catabolism|protocatechuate degradation http://purl.obolibrary.org/obo/GO_0019619 GO:0019616 biolink:BiologicalProcess catechol catabolic process, meta-cleavage The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom. MetaCyc:P183-PWY go.json catechol breakdown, meta-cleavage|catechol degradation, meta-cleavage http://purl.obolibrary.org/obo/GO_0019616 GO:0019617 biolink:BiologicalProcess protocatechuate catabolic process, meta-cleavage The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate. MetaCyc:P184-PWY go.json 3,4-dihydroxybenzoate catabolic process, meta-cleavage|protocatechuate breakdown, meta-cleavage|protocatechuate catabolic process to oxaloacetate and pyruvate|protocatechuate degradation, meta-cleavage http://purl.obolibrary.org/obo/GO_0019617 GO:0019614 biolink:BiologicalProcess catechol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. go.json catechol breakdown|catechol catabolic process|catechol catabolism|catechol degradation http://purl.obolibrary.org/obo/GO_0019614 GO:0019615 biolink:BiologicalProcess catechol catabolic process, ortho-cleavage The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups. MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY go.json catechol breakdown, ortho-cleavage|catechol degradation, ortho-cleavage http://purl.obolibrary.org/obo/GO_0019615 GO:0019612 biolink:BiologicalProcess 4-toluenecarboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. MetaCyc:4TOLCARBDEG-PWY go.json 4-toluenecarboxylate breakdown|4-toluenecarboxylate catabolism|4-toluenecarboxylate degradation|p-toluate catabolic process|p-toluate catabolism http://purl.obolibrary.org/obo/GO_0019612 GO:0019613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019613 GO:0019610 biolink:BiologicalProcess 3-hydroxyphenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY go.json 3-hydroxyphenylacetate breakdown|3-hydroxyphenylacetate catabolism|3-hydroxyphenylacetate degradation http://purl.obolibrary.org/obo/GO_0019610 GO:0019611 biolink:BiologicalProcess 4-toluenecarboxylate metabolic process The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. go.json 4-toluenecarboxylate metabolism|p-toluate metabolic process|p-toluate metabolism http://purl.obolibrary.org/obo/GO_0019611 GO:0019629 biolink:BiologicalProcess propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. go.json propionate breakdown, 2-methylcitrate cycle|propionate degradation, 2-methylcitrate cycle http://purl.obolibrary.org/obo/GO_0019629 GO:0019627 biolink:BiologicalProcess urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. go.json urea metabolism http://purl.obolibrary.org/obo/GO_0019627 GO:0019628 biolink:BiologicalProcess urate catabolic process The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine. MetaCyc:P165-PWY go.json urate breakdown|urate catabolism|urate degradation|uric acid catabolic process http://purl.obolibrary.org/obo/GO_0019628 GO:0019625 biolink:BiologicalProcess atrazine catabolic process to cyanuric acid The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid. MetaCyc:P141-PWY go.json atrazine breakdown to cyanuric acid|atrazine degradation to cyanuric acid http://purl.obolibrary.org/obo/GO_0019625 GO:0019626 biolink:BiologicalProcess short-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of less than 6 carbons. MetaCyc:ACETOACETATE-DEG-PWY go.json short-chain fatty acid breakdown|short-chain fatty acid catabolism|short-chain fatty acid degradation http://purl.obolibrary.org/obo/GO_0019626 GO:0019623 biolink:BiologicalProcess atrazine catabolic process to urea The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea. go.json atrazine breakdown to urea|atrazine degradation to urea http://purl.obolibrary.org/obo/GO_0019623 GO:0019624 biolink:BiologicalProcess atrazine catabolic process to isopropylamine The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine. go.json atrazine breakdown to isopropylamine|atrazine degradation to isopropylamine http://purl.obolibrary.org/obo/GO_0019624 GO:0019621 biolink:BiologicalProcess creatinine catabolic process to formate The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate. MetaCyc:CRNFORCAT-PWY go.json creatinine breakdown to formate|creatinine degradation to formate http://purl.obolibrary.org/obo/GO_0019621 GO:0019622 biolink:BiologicalProcess 3-(3-hydroxy)phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. MetaCyc:HCAMHPDEG-PWY go.json 3-(3-hydroxy)phenylpropionate breakdown|3-(3-hydroxy)phenylpropionate catabolism|3-(3-hydroxy)phenylpropionate degradation http://purl.obolibrary.org/obo/GO_0019622 GO:0019620 biolink:BiologicalProcess aerobic benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen. go.json aerobic benzoate metabolism http://purl.obolibrary.org/obo/GO_0019620 GO:0019609 biolink:BiologicalProcess 3-hydroxyphenylacetate metabolic process The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. go.json 3-hydroxyphenylacetate metabolism|3HPA metabolic process|3HPA metabolism http://purl.obolibrary.org/obo/GO_0019609 GO:0019607 biolink:BiologicalProcess phenylethylamine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. MetaCyc:2PHENDEG-PWY go.json phenylethylamine breakdown|phenylethylamine catabolism|phenylethylamine degradation http://purl.obolibrary.org/obo/GO_0019607 GO:0019608 biolink:BiologicalProcess nicotine catabolic process The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. MetaCyc:P181-PWY|UM-BBD_pathwayID:nic go.json nicotine breakdown|nicotine catabolism|nicotine degradation http://purl.obolibrary.org/obo/GO_0019608 GO:0019605 biolink:BiologicalProcess butyrate metabolic process The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid. go.json butanoic acid metabolic process|butanoic acid metabolism|butyrate metabolism|butyric acid metabolic process|butyric acid metabolism http://purl.obolibrary.org/obo/GO_0019605 GO:0019606 biolink:BiologicalProcess 2-oxobutyrate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. MetaCyc:2OXOBUTYRATECAT-PWY go.json 2-oxobutyrate breakdown|2-oxobutyrate catabolism|2-oxobutyrate degradation|alpha-ketobutyrate catabolic process|alpha-ketobutyrate catabolism http://purl.obolibrary.org/obo/GO_0019606 GO:0019603 biolink:BiologicalProcess toluene oxidation via 4-hydroxytoluene The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol). MetaCyc:TOLUENE-DEG-4-OH-PWY go.json http://purl.obolibrary.org/obo/GO_0019603 GO:0019604 biolink:BiologicalProcess toluene oxidation to catechol The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2). MetaCyc:TOLUENE-DEG-CATECHOL-PWY|UM-BBD_pathwayID:tol go.json http://purl.obolibrary.org/obo/GO_0019604 GO:0019601 biolink:BiologicalProcess toluene oxidation via 2-hydroxytoluene The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol). MetaCyc:TOLUENE-DEG-2-OH-PWY go.json http://purl.obolibrary.org/obo/GO_0019601 GO:0019602 biolink:BiologicalProcess toluene oxidation via 3-hydroxytoluene The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol). MetaCyc:TOLUENE-DEG-3-OH-PWY go.json http://purl.obolibrary.org/obo/GO_0019602 GO:0019600 biolink:BiologicalProcess toluene oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene. go.json http://purl.obolibrary.org/obo/GO_0019600 RO:0002091 biolink:OntologyClass starts during RO:0002091 go.json http://purl.obolibrary.org/obo/RO_0002091 RO:0002092 biolink:OntologyClass happens during RO:0002092 go.json http://purl.obolibrary.org/obo/RO_0002092 RO:0002093 biolink:OntologyClass ends during RO:0002093 go.json http://purl.obolibrary.org/obo/RO_0002093 RO:0002090 biolink:OntologyClass immediately precedes RO:0002090 go.json http://purl.obolibrary.org/obo/RO_0002090 RO:0002087 biolink:OntologyClass immediately preceded by RO:0002087 go.json http://purl.obolibrary.org/obo/RO_0002087 GO:0030138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030138 GO:0030139 biolink:CellularComponent endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. NIF_Subcellular:sao1362520468 go.json endocytotic transport vesicle|endocytotic vesicle http://purl.obolibrary.org/obo/GO_0030139 GO:0030136 biolink:CellularComponent clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. NIF_Subcellular:sao148845161 go.json http://purl.obolibrary.org/obo/GO_0030136 GO:0030137 biolink:CellularComponent COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. go.json coatomer http://purl.obolibrary.org/obo/GO_0030137 GO:0044786 biolink:BiologicalProcess cell cycle DNA replication The DNA-dependent DNA replication that takes place as part of the cell cycle. go.json http://purl.obolibrary.org/obo/GO_0044786 GO:0005178 biolink:MolecularActivity integrin binding Binding to an integrin. go.json integrin ligand http://purl.obolibrary.org/obo/GO_0005178 goslim_chembl GO:0044787 biolink:BiologicalProcess bacterial-type DNA replication The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome. go.json bacterial-type cell cycle DNA replication http://purl.obolibrary.org/obo/GO_0044787 GO:0005179 biolink:MolecularActivity hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. go.json cAMP generating peptide activity|glycopeptide hormone|lipopeptide hormone|peptide hormone http://purl.obolibrary.org/obo/GO_0005179 goslim_chembl GO:0044784 biolink:BiologicalProcess metaphase/anaphase transition of cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle. go.json http://purl.obolibrary.org/obo/GO_0044784 GO:0005176 biolink:MolecularActivity ErbB-2 class receptor binding Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2. go.json ErbB-2 class receptor ligand|HER2 receptor binding|HER2 receptor ligand|Neu receptor binding|Neu receptor ligand http://purl.obolibrary.org/obo/GO_0005176 GO:0005177 biolink:MolecularActivity obsolete neuroligin OBSOLETE. A class of ligands for neurexins. go.json neuroligin True http://purl.obolibrary.org/obo/GO_0005177 GO:0044785 biolink:BiologicalProcess metaphase/anaphase transition of meiotic cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis. go.json meiotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_0044785 GO:0044782 biolink:BiologicalProcess cilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. go.json microtubule-based flagellum organization http://purl.obolibrary.org/obo/GO_0044782 goslim_drosophila|goslim_generic GO:0005174 biolink:MolecularActivity CD40 receptor binding Binding to CD40, a receptor found on the surface of all B-lymphocytes. go.json http://purl.obolibrary.org/obo/GO_0005174 GO:0005175 biolink:MolecularActivity CD27 receptor binding Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells. go.json http://purl.obolibrary.org/obo/GO_0005175 GO:0044783 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044783 GO:0044780 biolink:BiologicalProcess bacterial-type flagellum assembly The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. go.json bacterial flagellum assembly http://purl.obolibrary.org/obo/GO_0044780 GO:0005172 biolink:MolecularActivity vascular endothelial growth factor receptor binding Binding to a vascular endothelial growth factor receptor. go.json VEGF receptor binding|VEGFR binding|vascular endothelial growth factor|vascular endothelial growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005172 GO:0005173 biolink:MolecularActivity stem cell factor receptor binding Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. go.json KIT binding|SCF|SCFR binding|stem cell factor|stem cell factor receptor ligand http://purl.obolibrary.org/obo/GO_0005173 GO:0044781 biolink:BiologicalProcess bacterial-type flagellum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. go.json http://purl.obolibrary.org/obo/GO_0044781 GO:0005181 biolink:MolecularActivity obsolete glycopeptide hormone OBSOLETE. (Was not defined before being made obsolete). go.json glycopeptide hormone True http://purl.obolibrary.org/obo/GO_0005181 GO:0005182 biolink:MolecularActivity obsolete lipopeptide hormone OBSOLETE. (Was not defined before being made obsolete). go.json lipopeptide hormone True http://purl.obolibrary.org/obo/GO_0005182 GO:0005180 biolink:MolecularActivity obsolete peptide hormone OBSOLETE. (Was not defined before being made obsolete). go.json peptide hormone True http://purl.obolibrary.org/obo/GO_0005180 GO:0044788 biolink:BiologicalProcess modulation by host of viral process A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. go.json http://purl.obolibrary.org/obo/GO_0044788 GO:0044789 biolink:BiologicalProcess obsolete modulation by host of viral release from host cell OBSOLETE. A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells. go.json True http://purl.obolibrary.org/obo/GO_0044789 GO:0030134 biolink:CellularComponent COPII-coated ER to Golgi transport vesicle A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport). go.json COPII vesicle|COPII-associated ER to Golgi transport vesicle|COPII-associated vesicle|COPII-coated vesicle|ER to Golgi constitutive secretory pathway transport vesicle|ER to Golgi transport vesicle|ER-Golgi transport vesicle|endoplasmic reticulum to Golgi transport vesicle|endoplasmic reticulum-Golgi transport vesicle http://purl.obolibrary.org/obo/GO_0030134 GO:0030135 biolink:CellularComponent coated vesicle Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. NIF_Subcellular:sao1985096626 go.json http://purl.obolibrary.org/obo/GO_0030135 goslim_drosophila GO:0030132 biolink:CellularComponent clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. go.json http://purl.obolibrary.org/obo/GO_0030132 GO:0030133 biolink:CellularComponent transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. NIF_Subcellular:sao885490876 go.json Golgi to vacuole transport vesicle|Golgi-vacuole transport vesicle|constitutive secretory pathway transport vesicle|secretory vesicle http://purl.obolibrary.org/obo/GO_0030133 GO:0030130 biolink:CellularComponent clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. go.json clathrin coat of TGN vesicle http://purl.obolibrary.org/obo/GO_0030130 GO:0030131 biolink:CellularComponent clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. go.json http://purl.obolibrary.org/obo/GO_0030131 GO:0044790 biolink:BiologicalProcess suppression of viral release by host A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells. go.json down regulation of release of virus from host|down regulation of viral exit|down regulation of viral release|down regulation of viral release from host cell|down regulation of viral shedding|down-regulation of release of virus from host|down-regulation of viral exit|down-regulation of viral release|down-regulation of viral release from host cell|down-regulation of viral shedding|downregulation of release of virus from host|downregulation of viral exit|downregulation of viral release|downregulation of viral release from host cell|downregulation of viral shedding|inhibition of release of virus from host|inhibition of viral exit|inhibition of viral release|inhibition of viral release from host cell|inhibition of viral shedding|negative regulation by host of viral release from host cell|negative regulation of release of virus from host|negative regulation of viral exit|negative regulation of viral release|negative regulation of viral release from host cell|negative regulation of viral shedding http://purl.obolibrary.org/obo/GO_0044790 GO:0030129 biolink:CellularComponent clathrin coat of synaptic vesicle A clathrin coat found on a synaptic vesicle. go.json http://purl.obolibrary.org/obo/GO_0030129 GO:0030127 biolink:CellularComponent COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. go.json http://purl.obolibrary.org/obo/GO_0030127 GO:0030128 biolink:CellularComponent clathrin coat of endocytic vesicle A clathrin coat found on an endocytic vesicle. go.json clathrin coat of endocytotic vesicle http://purl.obolibrary.org/obo/GO_0030128 GO:0030125 biolink:CellularComponent clathrin vesicle coat A clathrin coat found on a vesicle. go.json http://purl.obolibrary.org/obo/GO_0030125 GO:0030126 biolink:CellularComponent COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. go.json coatomer http://purl.obolibrary.org/obo/GO_0030126 GO:0005189 biolink:MolecularActivity obsolete milk protein OBSOLETE. (Was not defined before being made obsolete). go.json milk protein True http://purl.obolibrary.org/obo/GO_0005189 GO:0044797 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044797 GO:0044798 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044798 GO:0005187 biolink:MolecularActivity obsolete storage protein OBSOLETE. (Was not defined before being made obsolete). go.json storage protein True http://purl.obolibrary.org/obo/GO_0005187 GO:0044795 biolink:BiologicalProcess trans-Golgi network to recycling endosome transport The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes. go.json http://purl.obolibrary.org/obo/GO_0044795 GO:0044796 biolink:CellularComponent DNA polymerase processivity factor complex A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication. go.json http://purl.obolibrary.org/obo/GO_0044796 GO:0005188 biolink:MolecularActivity obsolete larval serum protein (sensu Insecta) OBSOLETE. (Was not defined before being made obsolete). go.json arylphorin|larval serum protein (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0005188 GO:0044793 biolink:BiologicalProcess negative regulation by host of viral process A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected. go.json http://purl.obolibrary.org/obo/GO_0044793 GO:0005185 biolink:MolecularActivity neurohypophyseal hormone activity The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin. go.json neurohypophysial hormone activity http://purl.obolibrary.org/obo/GO_0005185 GO:0044794 biolink:BiologicalProcess positive regulation by host of viral process A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. go.json http://purl.obolibrary.org/obo/GO_0044794 GO:0005186 biolink:MolecularActivity pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant. go.json http://purl.obolibrary.org/obo/GO_0005186 GO:0005183 biolink:MolecularActivity gonadotropin hormone-releasing hormone activity The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. go.json GnRH activity|LH/FSH-RF|LHRH activity|gonadotrophin hormone-releasing hormone activity|luteinizing hormone-releasing factor activity|luteinizing hormone-releasing hormone activity|luteinizing hormone/follicle-stimulating hormone releasing factor activity http://purl.obolibrary.org/obo/GO_0005183 GO:0044791 biolink:BiologicalProcess obsolete positive regulation by host of viral release from host cell OBSOLETE. A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells. go.json True http://purl.obolibrary.org/obo/GO_0044791 GO:0044792 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044792 GO:0005184 biolink:MolecularActivity neuropeptide hormone activity The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. Wikipedia:Neurohormone go.json neurohormone http://purl.obolibrary.org/obo/GO_0005184 goslim_chembl GO:0005192 biolink:MolecularActivity obsolete urinary protein OBSOLETE. (Was not defined before being made obsolete). go.json urinary protein True http://purl.obolibrary.org/obo/GO_0005192 GO:0005193 biolink:MolecularActivity obsolete major urinary protein OBSOLETE. (Was not defined before being made obsolete). go.json major urinary protein True http://purl.obolibrary.org/obo/GO_0005193 GO:0005190 biolink:MolecularActivity obsolete seminal fluid protein OBSOLETE. (Was not defined before being made obsolete). go.json seminal fluid protein True http://purl.obolibrary.org/obo/GO_0005190 GO:0005191 biolink:MolecularActivity obsolete acidic epididymal glycoprotein OBSOLETE. (Was not defined before being made obsolete). go.json acidic epididymal glycoprotein True http://purl.obolibrary.org/obo/GO_0005191 OBO:go#syngo_official_label biolink:OntologyClass label approved by the SynGO project go.json http://purl.obolibrary.org/obo/go#syngo_official_label GO:0044799 biolink:CellularComponent NarGHI complex A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit. go.json cytoplasmic membrane-bound quinol-nitrate oxidoreductase|nitrate reductase A http://purl.obolibrary.org/obo/GO_0044799 GO:0030123 biolink:CellularComponent AP-3 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). go.json http://purl.obolibrary.org/obo/GO_0030123 GO:0030124 biolink:CellularComponent AP-4 adaptor complex An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo. go.json http://purl.obolibrary.org/obo/GO_0030124 GO:0030121 biolink:CellularComponent AP-1 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). go.json AP-1 related adapter complex|HA1|HA1 clathrin adaptor http://purl.obolibrary.org/obo/GO_0030121 GO:0030122 biolink:CellularComponent AP-2 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). go.json HA2|HA2 clathrin adaptor http://purl.obolibrary.org/obo/GO_0030122 GO:0030120 biolink:CellularComponent vesicle coat A membrane coat found on a coated vesicle. NIF_Subcellular:sao1177708494 go.json http://purl.obolibrary.org/obo/GO_0030120 GO:0030118 biolink:CellularComponent clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. NIF_Subcellular:sao879919129|Wikipedia:Clathrin go.json clathrin cage http://purl.obolibrary.org/obo/GO_0030118 GO:0030119 biolink:CellularComponent AP-type membrane coat adaptor complex Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). go.json clathrin adaptor http://purl.obolibrary.org/obo/GO_0030119 goslim_pir GO:0030116 biolink:MolecularActivity glial cell-derived neurotrophic factor receptor binding A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors. go.json glial cell line-derived neurotrophic factor receptor binding|glial cell line-derived neurotrophic factor receptor ligand http://purl.obolibrary.org/obo/GO_0030116 GO:0030117 biolink:CellularComponent membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. go.json http://purl.obolibrary.org/obo/GO_0030117 GO:0030114 biolink:CellularComponent slime layer A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids. Wikipedia:Slime_layer go.json http://purl.obolibrary.org/obo/GO_0030114 GO:0005158 biolink:MolecularActivity insulin receptor binding Binding to an insulin receptor. go.json insulin receptor ligand http://purl.obolibrary.org/obo/GO_0005158 GO:0030115 biolink:CellularComponent S-layer A crystalline protein layer surrounding some bacteria. Wikipedia:S-layer go.json http://purl.obolibrary.org/obo/GO_0030115 goslim_pir GO:0005159 biolink:MolecularActivity insulin-like growth factor receptor binding Binding to an insulin-like growth factor receptor. go.json IGF receptor binding|insulin-like growth factor|insulin-like growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005159 GO:0005156 biolink:MolecularActivity obsolete epidermal growth factor receptor inhibiting ligand activity OBSOLETE. This term was not defined before being made obsolete. go.json EGF receptor inhibiting ligand activity|EGFR inhibiting ligand activity|epidermal growth factor receptor inhibiting ligand activity True http://purl.obolibrary.org/obo/GO_0005156 GO:0005157 biolink:MolecularActivity macrophage colony-stimulating factor receptor binding Binding to a macrophage colony-stimulating factor receptor. go.json M-CSF receptor binding|macrophage colony stimulating factor receptor binding|macrophage colony-stimulating factor receptor ligand http://purl.obolibrary.org/obo/GO_0005157 GO:0005154 biolink:MolecularActivity epidermal growth factor receptor binding Binding to an epidermal growth factor receptor. go.json EGF|EGF receptor binding|EGF receptor ligand|EGFR binding|TGF-alpha receptor binding|TGFalpha receptor binding|epidermal growth factor|epidermal growth factor receptor ligand|transforming growth factor alpha|transforming growth factor alpha receptor binding|transforming growth factor alpha receptor ligand http://purl.obolibrary.org/obo/GO_0005154 goslim_chembl GO:0005155 biolink:MolecularActivity obsolete epidermal growth factor receptor activating ligand activity OBSOLETE. This term was not defined before being made obsolete. go.json EGF receptor activating ligand activity|EGFR activating ligand activity|epidermal growth factor receptor activating ligand activity True http://purl.obolibrary.org/obo/GO_0005155 GO:0005152 biolink:MolecularActivity interleukin-1 receptor antagonist activity Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. go.json IL-1ra http://purl.obolibrary.org/obo/GO_0005152 GO:0005153 biolink:MolecularActivity interleukin-8 receptor binding Binding to an interleukin-8 receptor. go.json IL-8|interleukin-8 receptor ligand http://purl.obolibrary.org/obo/GO_0005153 goslim_chembl GO:0005150 biolink:MolecularActivity interleukin-1, type I receptor binding Binding to a Type I interleukin-1 receptor. go.json IL-1 type I|interleukin-1, type I receptor ligand http://purl.obolibrary.org/obo/GO_0005150 GO:0005151 biolink:MolecularActivity interleukin-1, type II receptor binding Binding to a Type II interleukin-1 receptor. go.json IL-1 type II|interleukin-1, type II receptor ligand http://purl.obolibrary.org/obo/GO_0005151 GO:0005160 biolink:MolecularActivity transforming growth factor beta receptor binding Binding to a transforming growth factor beta receptor. go.json TGF-beta receptor binding|TGFbeta receptor binding|activin|inhibin|transforming growth factor beta|transforming growth factor beta ligand binding to type I receptor|transforming growth factor beta ligand binding to type II receptor|transforming growth factor beta receptor anchoring activity|transforming growth factor beta receptor ligand http://purl.obolibrary.org/obo/GO_0005160 GO:0019799 biolink:MolecularActivity tubulin N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. EC:2.3.1.108|MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN|RHEA:15277 go.json TAT activity|acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity|acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity|acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity|alpha-tubulin N-acetyltransferase activity|alpha-tubulin acetylase activity|alpha-tubulin acetyltransferase activity|tubulin acetyltransferase activity http://purl.obolibrary.org/obo/GO_0019799 GO:0019797 biolink:MolecularActivity procollagen-proline 3-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. EC:1.14.11.7|KEGG_REACTION:R03218|MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN|RHEA:22872|Reactome:R-HSA-1980233 go.json procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|procollagen-proline,2-oxoglutarate 3-dioxygenase activity|proline,2-oxoglutarate 3-dioxygenase activity|prolyl 3-hydroxylase activity|prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity|protocollagen proline 3-hydroxylase activity http://purl.obolibrary.org/obo/GO_0019797 GO:0030112 biolink:CellularComponent glycocalyx A carbohydrate rich layer at the outermost periphery of a cell. Wikipedia:Glycocalyx go.json http://purl.obolibrary.org/obo/GO_0030112 goslim_pir GO:0019798 biolink:MolecularActivity procollagen-proline dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. go.json http://purl.obolibrary.org/obo/GO_0019798 GO:0030113 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030113 GO:0019795 biolink:BiologicalProcess obsolete nonprotein amino acid biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins. go.json nonprotein amino acid anabolism|nonprotein amino acid biosynthesis|nonprotein amino acid biosynthetic process|nonprotein amino acid formation|nonprotein amino acid synthesis True http://purl.obolibrary.org/obo/GO_0019795 GO:0030110 biolink:MolecularActivity HLA-C specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0030110 GO:0030111 biolink:BiologicalProcess regulation of Wnt signaling pathway Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. go.json regulation of Wnt receptor signaling pathway|regulation of Wnt receptor signalling pathway|regulation of Wnt-activated signaling pathway|regulation of frizzled signaling pathway|regulation of frizzled signalling pathway http://purl.obolibrary.org/obo/GO_0030111 GO:0019796 biolink:BiologicalProcess obsolete nonprotein amino acid catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins. go.json nonprotein amino acid breakdown|nonprotein amino acid catabolic process|nonprotein amino acid catabolism|nonprotein amino acid degradation True http://purl.obolibrary.org/obo/GO_0019796 GO:0019793 biolink:MolecularActivity obsolete ISG15 carrier activity OBSOLETE. Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other. go.json ISG15 carrier activity|interferon-stimulated gene-15 carrier activity True http://purl.obolibrary.org/obo/GO_0019793 GO:0019794 biolink:BiologicalProcess obsolete nonprotein amino acid metabolic process OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins. go.json nonprotein amino acid metabolic process|nonprotein amino acid metabolism True http://purl.obolibrary.org/obo/GO_0019794 GO:0019791 biolink:MolecularActivity obsolete FAT10 hydrolase activity OBSOLETE. (Was not defined before being made obsolete). go.json FAT10 hydrolase activity True http://purl.obolibrary.org/obo/GO_0019791 GO:0019792 biolink:MolecularActivity obsolete APG12 hydrolase activity OBSOLETE. (Was not defined before being made obsolete). go.json APG12 hydrolase activity True http://purl.obolibrary.org/obo/GO_0019792 GO:0030109 biolink:MolecularActivity HLA-B specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0030109 GO:0030107 biolink:MolecularActivity HLA-A specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0030107 GO:0030108 biolink:MolecularActivity HLA-A specific activating MHC class I receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0030108 GO:0030105 biolink:BiologicalProcess obsolete anaphylaxis OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances. go.json anaphylaxis True http://purl.obolibrary.org/obo/GO_0030105 GO:0030106 biolink:MolecularActivity obsolete MHC class I receptor activity OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells). go.json MHC class I receptor activity|class I major histocompatibility complex antigen|major histocompatibility complex class I receptor True http://purl.obolibrary.org/obo/GO_0030106 GO:0030103 biolink:BiologicalProcess vasopressin secretion The regulated release of vasopressin from secretory granules into the blood. go.json http://purl.obolibrary.org/obo/GO_0030103 GO:0005169 biolink:MolecularActivity neurotrophin TRKB receptor binding Binding to a neurotrophin TRKB receptor. go.json neurotrophin TRKB receptor ligand http://purl.obolibrary.org/obo/GO_0005169 GO:0030104 biolink:BiologicalProcess obsolete water homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of water within an organism or cell. Wikipedia:Osmoregulation go.json osmoregulation|regulation of osmotic pressure True http://purl.obolibrary.org/obo/GO_0030104 GO:0005167 biolink:MolecularActivity neurotrophin TRK receptor binding Binding to a neurotrophin TRK receptor. go.json neurotrophin TRK receptor ligand http://purl.obolibrary.org/obo/GO_0005167 GO:0005168 biolink:MolecularActivity neurotrophin TRKA receptor binding Binding to a neurotrophin TRKA receptor. go.json neurotrophin TRKA receptor ligand http://purl.obolibrary.org/obo/GO_0005168 GO:0005165 biolink:MolecularActivity neurotrophin receptor binding Binding to a neurotrophin receptor. go.json neurotrophin|neurotrophin receptor ligand http://purl.obolibrary.org/obo/GO_0005165 GO:0005166 biolink:MolecularActivity neurotrophin p75 receptor binding Binding to a neurotrophin p75 receptor. go.json neurotrophin p75 receptor ligand http://purl.obolibrary.org/obo/GO_0005166 GO:0005163 biolink:MolecularActivity nerve growth factor receptor binding Binding to a nerve growth factor receptor. go.json NGF receptor binding|nerve growth factor receptor ligand|neurotrophin http://purl.obolibrary.org/obo/GO_0005163 GO:0005164 biolink:MolecularActivity tumor necrosis factor receptor binding Binding to a tumor necrosis factor receptor. go.json TNF receptor binding|tumor necrosis factor|tumor necrosis factor receptor ligand http://purl.obolibrary.org/obo/GO_0005164 goslim_chembl GO:0005161 biolink:MolecularActivity platelet-derived growth factor receptor binding Binding to a platelet-derived growth factor receptor. go.json PDGF|PDGF receptor binding|PDGFR binding|platelet-derived growth factor|platelet-derived growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005161 GO:0005162 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005162 GO:0005170 biolink:MolecularActivity neurotrophin TRKC receptor binding Binding to a neurotrophin TRKC receptor. go.json neurotrophin TRKC receptor ligand http://purl.obolibrary.org/obo/GO_0005170 GO:0005171 biolink:MolecularActivity hepatocyte growth factor receptor binding Binding to an hepatocyte growth factor receptor. go.json HGF receptor binding|hepatocyte growth factor|hepatocyte growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005171 GO:0030101 biolink:BiologicalProcess natural killer cell activation The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. go.json NK cell activation http://purl.obolibrary.org/obo/GO_0030101 GO:0030102 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030102 GO:0030100 biolink:BiologicalProcess regulation of endocytosis Any process that modulates the frequency, rate or extent of endocytosis. go.json http://purl.obolibrary.org/obo/GO_0030100 GO:0005138 biolink:MolecularActivity interleukin-6 receptor binding Binding to an interleukin-6 receptor. go.json IL-6|interleukin-6 receptor ligand http://purl.obolibrary.org/obo/GO_0005138 goslim_chembl GO:0005139 biolink:MolecularActivity interleukin-7 receptor binding Binding to an interleukin-7 receptor. go.json IL-7|interleukin-7 receptor ligand http://purl.obolibrary.org/obo/GO_0005139 GO:0005136 biolink:MolecularActivity interleukin-4 receptor binding Binding to an interleukin-4 receptor. go.json IL-4|interleukin-4 receptor ligand http://purl.obolibrary.org/obo/GO_0005136 GO:0005137 biolink:MolecularActivity interleukin-5 receptor binding Binding to an interleukin-5 receptor. go.json IL-5|interleukin-5 receptor ligand http://purl.obolibrary.org/obo/GO_0005137 goslim_chembl GO:0005134 biolink:MolecularActivity interleukin-2 receptor binding Binding to an interleukin-2 receptor. go.json IL-2|interleukin-2 receptor ligand http://purl.obolibrary.org/obo/GO_0005134 GO:0005135 biolink:MolecularActivity interleukin-3 receptor binding Binding to an interleukin-3 receptor. go.json IL-3|interleukin-3 receptor ligand http://purl.obolibrary.org/obo/GO_0005135 GO:0005132 biolink:MolecularActivity type I interferon receptor binding Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). go.json IFNAR binding|IFNAR1 binding|IFNAR2 binding|interferon-alpha/beta|interferon-alpha/beta receptor binding|interferon-alpha/beta receptor ligand http://purl.obolibrary.org/obo/GO_0005132 GO:0005133 biolink:MolecularActivity type II interferon receptor binding Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma. go.json interferon-gamma|interferon-gamma receptor binding|interferon-gamma receptor ligand http://purl.obolibrary.org/obo/GO_0005133 GO:0005130 biolink:MolecularActivity granulocyte colony-stimulating factor receptor binding Binding to a granulocyte colony-stimulating factor receptor. go.json G-CSF receptor ligand|GC-SF receptor ligand|granulocyte colony stimulating factor receptor binding|granulocyte colony-stimulating factor|granulocyte colony-stimulating factor receptor ligand http://purl.obolibrary.org/obo/GO_0005130 GO:0005131 biolink:MolecularActivity growth hormone receptor binding Binding to a growth hormone receptor. go.json growth hormone|growth hormone receptor ligand http://purl.obolibrary.org/obo/GO_0005131 RO:0002131 biolink:OntologyClass overlaps RO:0002131 go.json http://purl.obolibrary.org/obo/RO_0002131 GO:0019779 biolink:MolecularActivity Atg8 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond. go.json APG7|APG8 activating enzyme activity http://purl.obolibrary.org/obo/GO_0019779 GO:0019777 biolink:MolecularActivity Atg12 transferase activity Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages. Reactome:R-HSA-5681999 go.json APG12 conjugating enzyme activity|APG12 ligase activity|Atg12 conjugating enzyme activity|Atg12 ligase activity http://purl.obolibrary.org/obo/GO_0019777 GO:0019778 biolink:MolecularActivity Atg12 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond. go.json APG12 activating enzyme activity http://purl.obolibrary.org/obo/GO_0019778 GO:0019775 biolink:MolecularActivity FAT10 transferase activity Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages. go.json FAT10 conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0019775 GO:0019776 biolink:MolecularActivity Atg8-family ligase activity Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifer to phosphatidylethanolamine or phosphatidylserine on a membrane. Reactome:R-HSA-5681981 go.json APG8 ligase activity|Atg8 ligase activity|Atg8-like ligase activity http://purl.obolibrary.org/obo/GO_0019776 GO:0019773 biolink:CellularComponent proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0019773 GO:0019774 biolink:CellularComponent proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0019774 GO:0019771 biolink:MolecularActivity high-affinity IgG receptor activity Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json high affinity Fc receptor activity|high affinity IgG receptor activity http://purl.obolibrary.org/obo/GO_0019771 GO:0019772 biolink:MolecularActivity low-affinity IgG receptor activity Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json low affinity Fc receptor activity|low affinity IgG receptor activity http://purl.obolibrary.org/obo/GO_0019772 GO:0019770 biolink:MolecularActivity IgG receptor activity Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0019770 GO:0019790 biolink:MolecularActivity obsolete ubiquitin-like hydrolase activity OBSOLETE. (Was not defined before being made obsolete). go.json ubiquitin-like hydrolase activity True http://purl.obolibrary.org/obo/GO_0019790 GO:0005149 biolink:MolecularActivity interleukin-1 receptor binding Binding to an interleukin-1 receptor. go.json IL-1|interleukin-1 receptor ligand http://purl.obolibrary.org/obo/GO_0005149 GO:0005147 biolink:MolecularActivity oncostatin-M receptor binding Binding to an oncostatin-M receptor. go.json oncostatin-M|oncostatin-M receptor ligand http://purl.obolibrary.org/obo/GO_0005147 GO:0005148 biolink:MolecularActivity prolactin receptor binding Binding to a prolactin receptor. go.json prolactin|prolactin receptor ligand http://purl.obolibrary.org/obo/GO_0005148 GO:0005145 biolink:MolecularActivity obsolete interleukin-14 receptor binding OBSOLETE. Binding to an interleukin-14 receptor. go.json IL-14|interleukin-14 receptor ligand True http://purl.obolibrary.org/obo/GO_0005145 GO:0005146 biolink:MolecularActivity leukemia inhibitory factor receptor binding Binding to an leukemia inhibitory factor receptor. go.json leukemia inhibitory factor|leukemia inhibitory factor receptor ligand http://purl.obolibrary.org/obo/GO_0005146 GO:0005143 biolink:MolecularActivity interleukin-12 receptor binding Binding to an interleukin-12 receptor. go.json IL-12|interleukin-12 receptor ligand http://purl.obolibrary.org/obo/GO_0005143 GO:0005144 biolink:MolecularActivity interleukin-13 receptor binding Binding to an interleukin-13 receptor. go.json IL-13|interleukin-13 receptor ligand http://purl.obolibrary.org/obo/GO_0005144 GO:0005141 biolink:MolecularActivity interleukin-10 receptor binding Binding to an interleukin-10 receptor. go.json IL-10|interleukin-10 receptor ligand http://purl.obolibrary.org/obo/GO_0005141 GO:0005142 biolink:MolecularActivity interleukin-11 receptor binding Binding to an interleukin-11 receptor. go.json IL-11|interleukin-11 receptor ligand http://purl.obolibrary.org/obo/GO_0005142 GO:0005140 biolink:MolecularActivity interleukin-9 receptor binding Binding to an interleukin-9 receptor. go.json IL-9|interleukin-9 receptor ligand http://purl.obolibrary.org/obo/GO_0005140 GO:0019788 biolink:MolecularActivity NEDD8 transferase activity Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. Reactome:R-HSA-8951648|Reactome:R-HSA-8951661|Reactome:R-HSA-8951764|Reactome:R-HSA-8952044|Reactome:R-HSA-8952618|Reactome:R-HSA-8952626|Reactome:R-HSA-8952631|Reactome:R-HSA-8952638|Reactome:R-HSA-8956025 go.json Hub1 conjugating enzyme activity|NEDD8 conjugating enzyme activity|RUB1 conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0019788 GO:0019789 biolink:MolecularActivity SUMO transferase activity Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. Reactome:R-HSA-2993769|Reactome:R-HSA-2993780|Reactome:R-HSA-2993790|Reactome:R-HSA-2997616|Reactome:R-HSA-2997706|Reactome:R-HSA-2997709|Reactome:R-HSA-2997723|Reactome:R-HSA-3000348|Reactome:R-HSA-3000383|Reactome:R-HSA-3000399|Reactome:R-HSA-3000411|Reactome:R-HSA-3000433|Reactome:R-HSA-3000434|Reactome:R-HSA-3000449|Reactome:R-HSA-3108203|Reactome:R-HSA-3108209|Reactome:R-HSA-3108212|Reactome:R-HSA-3232162|Reactome:R-HSA-3234081|Reactome:R-HSA-3234084|Reactome:R-HSA-3234094|Reactome:R-HSA-3247493|Reactome:R-HSA-3296126|Reactome:R-HSA-3465545|Reactome:R-HSA-3782535|Reactome:R-HSA-3899291|Reactome:R-HSA-3900047|Reactome:R-HSA-3900070|Reactome:R-HSA-3900177|Reactome:R-HSA-3900194|Reactome:R-HSA-3903017|Reactome:R-HSA-3927824|Reactome:R-HSA-3927886|Reactome:R-HSA-3927959|Reactome:R-HSA-3968362|Reactome:R-HSA-3968414|Reactome:R-HSA-4085296|Reactome:R-HSA-4085318|Reactome:R-HSA-4085331|Reactome:R-HSA-4085347|Reactome:R-HSA-4085350|Reactome:R-HSA-4085372|Reactome:R-HSA-4085992|Reactome:R-HSA-4085994|Reactome:R-HSA-4086036|Reactome:R-HSA-4086059|Reactome:R-HSA-4086083|Reactome:R-HSA-4086088|Reactome:R-HSA-4090281|Reactome:R-HSA-4090284|Reactome:R-HSA-4090288|Reactome:R-HSA-4090390|Reactome:R-HSA-4090408|Reactome:R-HSA-4341016|Reactome:R-HSA-4341025|Reactome:R-HSA-4341048|Reactome:R-HSA-4341070|Reactome:R-HSA-4341072|Reactome:R-HSA-4341073|Reactome:R-HSA-4546385|Reactome:R-HSA-4546386|Reactome:R-HSA-4546387|Reactome:R-HSA-4551604|Reactome:R-HSA-4551616|Reactome:R-HSA-4551648|Reactome:R-HSA-4551649|Reactome:R-HSA-4551655|Reactome:R-HSA-4551661|Reactome:R-HSA-4551679|Reactome:R-HSA-4551683|Reactome:R-HSA-4551721|Reactome:R-HSA-4551724|Reactome:R-HSA-4551727|Reactome:R-HSA-4551738|Reactome:R-HSA-4551768|Reactome:R-HSA-4568846|Reactome:R-HSA-4568848|Reactome:R-HSA-4568863|Reactome:R-HSA-4568914|Reactome:R-HSA-4570463|Reactome:R-HSA-4570467|Reactome:R-HSA-4570485|Reactome:R-HSA-4570489|Reactome:R-HSA-4570493|Reactome:R-HSA-4570496|Reactome:R-HSA-4570499|Reactome:R-HSA-4570528|Reactome:R-HSA-4570553|Reactome:R-HSA-4570554|Reactome:R-HSA-4615839|Reactome:R-HSA-4615872|Reactome:R-HSA-4615873|Reactome:R-HSA-4615889|Reactome:R-HSA-4615900|Reactome:R-HSA-4615905|Reactome:R-HSA-4615910|Reactome:R-HSA-4615933|Reactome:R-HSA-4615987|Reactome:R-HSA-4616015|Reactome:R-HSA-4641342|Reactome:R-HSA-4641345|Reactome:R-HSA-4641350|Reactome:R-HSA-4641362|Reactome:R-HSA-4655355|Reactome:R-HSA-4655374|Reactome:R-HSA-4655431|Reactome:R-HSA-4655440|Reactome:R-HSA-4656914|Reactome:R-HSA-4717461|Reactome:R-HSA-4717521|Reactome:R-HSA-4719413|Reactome:R-HSA-4719423|Reactome:R-HSA-4719424|Reactome:R-HSA-4719436|Reactome:R-HSA-4719447|Reactome:R-HSA-4719448|Reactome:R-HSA-4720432|Reactome:R-HSA-4720446|Reactome:R-HSA-4755411|Reactome:R-HSA-4755478|Reactome:R-HSA-4755479|Reactome:R-HSA-4755494|Reactome:R-HSA-4755526|Reactome:R-HSA-4755536|Reactome:R-HSA-5228508|Reactome:R-HSA-5228521|Reactome:R-HSA-5228523|Reactome:R-HSA-5228525|Reactome:R-HSA-5682607|Reactome:R-HSA-5684052|Reactome:R-HSA-6790454|Reactome:R-HSA-6804468|Reactome:R-HSA-6804485|Reactome:R-HSA-8956365 go.json SMT3 conjugating enzyme|SUMO conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0019789 GO:0019786 biolink:MolecularActivity protein-phosphatidylethanolamide deconjugating activity Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue. go.json APG8-PE hydrolase|APG8-specific protease activity|ATG8-PE deconjugation activity|ATG8-PE hydrolase activity|Atg8-specific peptidase activity|Atg8-specific protease activity http://purl.obolibrary.org/obo/GO_0019786 GO:0019787 biolink:MolecularActivity ubiquitin-like protein transferase activity Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. Reactome:R-HSA-5678490|Reactome:R-HSA-688137 go.json E2|E3|small conjugating protein ligase activity|small conjugating protein transferase activity|small protein conjugating enzyme activity|ubiquitin-like conjugating enzyme activity|ubiquitin-like-protein ligase activity http://purl.obolibrary.org/obo/GO_0019787 goslim_drosophila|goslim_pir GO:0019784 biolink:MolecularActivity deNEDDylase activity An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. Reactome:R-HSA-5690808|Reactome:R-HSA-8863723|Reactome:R-HSA-8956040|Reactome:R-HSA-8956045 go.json NEDD8-specific protease activity http://purl.obolibrary.org/obo/GO_0019784 GO:0019785 biolink:MolecularActivity ISG15-specific peptidase activity A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated. Reactome:R-HSA-1678841|Reactome:R-HSA-5653786|Reactome:R-HSA-9729725|Reactome:R-HSA-9755244 go.json ISG15-specific protease activity http://purl.obolibrary.org/obo/GO_0019785 GO:0019782 biolink:MolecularActivity ISG15 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond. go.json UBE1L http://purl.obolibrary.org/obo/GO_0019782 GO:0019783 biolink:MolecularActivity ubiquitin-like protein peptidase activity An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins. go.json small conjugating protein-specific isopeptidase activity|small conjugating protein-specific protease activity|ubiquitin-like hydrolase activity|ubiquitin-like protein-specific isopeptidase activity|ubiquitin-like protein-specific protease activity|ubiquitin-like specific protease activity|ubiquitin-like-protein-specific protease activity|ubiquitin-specific protease activity involved in negative regulation of ERAD pathway|ubiquitin-specific protease activity involved in positive regulation of ERAD pathway|ubiquitinyl-like hydrolase activity http://purl.obolibrary.org/obo/GO_0019783 GO:0019780 biolink:MolecularActivity FAT10 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond. go.json http://purl.obolibrary.org/obo/GO_0019780 GO:0019781 biolink:MolecularActivity NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. EC:6.2.1.64 go.json RUB1 activating enzyme activity http://purl.obolibrary.org/obo/GO_0019781 GO:0005118 biolink:MolecularActivity sevenless binding Binding to a sevenless (sev) protein, a receptor tyrosine kinase. go.json sev binding|sev ligand|sevenless ligand http://purl.obolibrary.org/obo/GO_0005118 GO:0005119 biolink:MolecularActivity smoothened binding Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. go.json smo binding|smo ligand|smoothened ligand http://purl.obolibrary.org/obo/GO_0005119 GO:0005116 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005116 GO:0005117 biolink:MolecularActivity wishful thinking binding Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor. go.json SE20 receptor binding|Wit binding|Wit ligand|wishful thinking ligand http://purl.obolibrary.org/obo/GO_0005117 GO:0005114 biolink:MolecularActivity type II transforming growth factor beta receptor binding Binding to a type II transforming growth factor beta receptor. go.json TGF-beta type II binding|punt binding|punt ligand|transforming growth factor beta ligand binding to type II receptor|transforming growth factor beta receptor type II binding|type II TGF-beta binding http://purl.obolibrary.org/obo/GO_0005114 GO:0005115 biolink:MolecularActivity receptor tyrosine kinase-like orphan receptor binding Binding to a receptor tyrosine kinase-like orphan receptor (Ror). go.json Ror binding|Ror ligand|receptor tyrosine kinase-like orphan receptor ligand http://purl.obolibrary.org/obo/GO_0005115 GO:0005112 biolink:MolecularActivity Notch binding Binding to a Notch (N) protein, a surface receptor. go.json N binding|N ligand|Notch ligand|Notch receptor binding http://purl.obolibrary.org/obo/GO_0005112 GO:0005113 biolink:MolecularActivity patched binding Binding to a patched (ptc) protein, a receptor for hedgehog proteins. go.json patched ligand|ptc binding|ptc ligand http://purl.obolibrary.org/obo/GO_0005113 GO:0005110 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005110 GO:0005111 biolink:MolecularActivity type 2 fibroblast growth factor receptor binding Binding to a type 2 fibroblast growth factor receptor (FGFR2). go.json FGFR2 binding|FGFR2 ligand|heartless binding|heartless ligand|type 2 fibroblast growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005111 GO:0019759 biolink:BiologicalProcess glycosinolate catabolic process The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. go.json glycosinolate breakdown|glycosinolate catabolism|glycosinolate degradation http://purl.obolibrary.org/obo/GO_0019759 GO:0019757 biolink:BiologicalProcess glycosinolate metabolic process The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. go.json glycosinolate metabolism http://purl.obolibrary.org/obo/GO_0019757 GO:0019758 biolink:BiologicalProcess glycosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. go.json glycosinolate anabolism|glycosinolate biosynthesis|glycosinolate formation|glycosinolate synthesis http://purl.obolibrary.org/obo/GO_0019758 GO:0019755 biolink:BiologicalProcess one-carbon compound transport The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json one carbon compound transport http://purl.obolibrary.org/obo/GO_0019755 GO:0019756 biolink:BiologicalProcess cyanogenic glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. go.json cyanogenic glycoside anabolism|cyanogenic glycoside biosynthesis|cyanogenic glycoside formation|cyanogenic glycoside synthesis http://purl.obolibrary.org/obo/GO_0019756 GO:0019753 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019753 GO:0019754 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019754 GO:0019751 biolink:BiologicalProcess polyol metabolic process The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. go.json polyhydric alcohol metabolic process|polyol metabolism http://purl.obolibrary.org/obo/GO_0019751 GO:0019752 biolink:BiologicalProcess carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). go.json carboxylic acid metabolism http://purl.obolibrary.org/obo/GO_0019752 GO:0019750 biolink:BiologicalProcess chloroplast localization Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants. go.json chloroplast localisation http://purl.obolibrary.org/obo/GO_0019750 GO:0005129 biolink:MolecularActivity granulocyte macrophage colony-stimulating factor receptor binding Binding to a granulocyte macrophage colony-stimulating factor receptor. go.json GM-CSF receptor binding|GM-CSF receptor ligand|GMC-SF receptor ligand|granulocyte macrophage colony stimulating factor receptor binding|granulocyte macrophage colony-stimulating factor|granulocyte macrophage colony-stimulating factor receptor ligand http://purl.obolibrary.org/obo/GO_0005129 GO:0005127 biolink:MolecularActivity ciliary neurotrophic factor receptor binding Binding to a ciliary neurotrophic factor receptor. go.json ciliary neurotrophic factor|ciliary neurotrophic factor receptor ligand http://purl.obolibrary.org/obo/GO_0005127 GO:0005128 biolink:MolecularActivity erythropoietin receptor binding Binding to an erythropoietin receptor. go.json erythropoietin|erythropoietin receptor ligand http://purl.obolibrary.org/obo/GO_0005128 GO:0005125 biolink:MolecularActivity cytokine activity The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. go.json autocrine activity|paracrine activity http://purl.obolibrary.org/obo/GO_0005125 goslim_chembl GO:0005126 biolink:MolecularActivity cytokine receptor binding Binding to a cytokine receptor. go.json hematopoietin/interferon-class (D200-domain) cytokine receptor binding|hematopoietin/interferon-class (D200-domain) cytokine receptor ligand http://purl.obolibrary.org/obo/GO_0005126 GO:0005123 biolink:MolecularActivity death receptor binding Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). go.json APO binding|DR binding|EDAR binding|FAS binding|KILLER binding|NGFR binding|TNFR1 binding|TRAIL binding|death receptor adaptor protein activity|death receptor interacting protein activity|death receptor ligand|death receptor-associated factor activity http://purl.obolibrary.org/obo/GO_0005123 goslim_chembl GO:0005124 biolink:MolecularActivity scavenger receptor binding Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. go.json scavenger receptor ligand http://purl.obolibrary.org/obo/GO_0005124 GO:0005121 biolink:MolecularActivity Toll binding Binding to a Toll protein, a transmembrane receptor. go.json Tl binding|Toll ligand|Toll receptor binding http://purl.obolibrary.org/obo/GO_0005121 GO:0005122 biolink:MolecularActivity torso binding Binding to a torso (tor) protein, a receptor tyrosine kinase. go.json tor binding|tor ligand|torso ligand http://purl.obolibrary.org/obo/GO_0005122 GO:0005120 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005120 GO:0019768 biolink:MolecularActivity high-affinity IgE receptor activity Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json high affinity Fc receptor activity|high affinity IgE receptor activity http://purl.obolibrary.org/obo/GO_0019768 GO:0019769 biolink:MolecularActivity low-affinity IgE receptor activity Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json low affinity Fc receptor activity|low affinity IgE receptor activity http://purl.obolibrary.org/obo/GO_0019769 GO:0019766 biolink:MolecularActivity IgA receptor activity Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0019766 GO:0019767 biolink:MolecularActivity IgE receptor activity Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0019767 GO:0019764 biolink:MolecularActivity obsolete high affinity Fc receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json high affinity Fc receptor activity True http://purl.obolibrary.org/obo/GO_0019764 GO:0019765 biolink:MolecularActivity obsolete low affinity Fc receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json low affinity Fc receptor activity True http://purl.obolibrary.org/obo/GO_0019765 GO:0019762 biolink:BiologicalProcess glucosinolate catabolic process The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. MetaCyc:PWY-5267 go.json glucosinolate breakdown|glucosinolate catabolism|glucosinolate degradation http://purl.obolibrary.org/obo/GO_0019762 GO:0019763 biolink:MolecularActivity immunoglobulin receptor activity Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json FC receptor activity http://purl.obolibrary.org/obo/GO_0019763 GO:0019760 biolink:BiologicalProcess glucosinolate metabolic process The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans. go.json glucosinolate metabolism http://purl.obolibrary.org/obo/GO_0019760 GO:0019761 biolink:BiologicalProcess glucosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. go.json glucosinolate anabolism|glucosinolate biosynthesis|glucosinolate formation|glucosinolate synthesis http://purl.obolibrary.org/obo/GO_0019761 GO:0044706 biolink:BiologicalProcess multi-multicellular organism process A multicellular organism process which involves another multicellular organism of the same or different species. go.json http://purl.obolibrary.org/obo/GO_0044706 GO:0044707 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044707 GO:0044704 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044704 GO:0044705 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044705 GO:0044702 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044702 GO:0044703 biolink:BiologicalProcess multi-organism reproductive process A biological process that directly contributes to the process of producing new individuals, involving another organism. go.json http://purl.obolibrary.org/obo/GO_0044703 goslim_drosophila GO:0044700 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044700 GO:0044701 biolink:BiologicalProcess obsolete response to stimulus by single organism OBSOLETE. A response to a stimulus that involves only one organism. go.json response to stimulus by single organism True http://purl.obolibrary.org/obo/GO_0044701 GO:0044708 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044708 GO:0044709 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044709 GO:0044710 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044710 GO:0044717 biolink:MolecularActivity 8-hydroxy-dADP phosphatase activity Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate. Reactome:R-HSA-2395965 go.json http://purl.obolibrary.org/obo/GO_0044717 GO:0044718 biolink:BiologicalProcess siderophore transmembrane transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore. go.json siderophore membrane transport http://purl.obolibrary.org/obo/GO_0044718 GO:0044715 biolink:MolecularActivity 8-oxo-dGDP phosphatase activity Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate. EC:3.6.1.58|RHEA:32063|Reactome:R-HSA-2395876|Reactome:R-HSA-2395879 go.json http://purl.obolibrary.org/obo/GO_0044715 GO:0044716 biolink:MolecularActivity 8-oxo-GDP phosphatase activity Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate. EC:3.6.1.58|RHEA:62356|Reactome:R-HSA-2395873 go.json http://purl.obolibrary.org/obo/GO_0044716 GO:0044713 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044713 GO:0044714 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044714 GO:0044711 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044711 GO:0044712 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044712 GO:0044719 biolink:BiologicalProcess regulation of imaginal disc-derived wing size Any process that modulates the size of an imaginal disc-derived wing. go.json http://purl.obolibrary.org/obo/GO_0044719 GO:0044720 biolink:BiologicalProcess negative regulation of imaginal disc-derived wing size Any process that reduces the size of an imaginal disc-derived wing. go.json http://purl.obolibrary.org/obo/GO_0044720 GO:0044721 biolink:BiologicalProcess protein import into peroxisome matrix, substrate release The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane. go.json http://purl.obolibrary.org/obo/GO_0044721 GO:0030192 biolink:MolecularActivity obsolete Hsp70/Hsc70 protein regulator activity OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class. go.json Hsp70/Hsc70 protein regulator activity True http://purl.obolibrary.org/obo/GO_0030192 GO:0044728 biolink:BiologicalProcess obsolete DNA methylation or demethylation OBSOLETE. The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. go.json changes in DNA methylation True http://purl.obolibrary.org/obo/GO_0044728 GO:0044729 biolink:MolecularActivity hemi-methylated DNA-binding Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. go.json double-stranded hemi-methylated DNA binding http://purl.obolibrary.org/obo/GO_0044729 GO:0030193 biolink:BiologicalProcess regulation of blood coagulation Any process that modulates the frequency, rate or extent of blood coagulation. go.json http://purl.obolibrary.org/obo/GO_0030193 GO:0030190 biolink:MolecularActivity obsolete chaperone inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone. go.json chaperone inhibitor activity True http://purl.obolibrary.org/obo/GO_0030190 GO:0044726 biolink:BiologicalProcess epigenetic programing of female pronucleus The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1. go.json maintenance of DNA methylation at imprinted genes|protection of DNA demethylation of female pronucleus|protection of DNA methylation in female pronucleus http://purl.obolibrary.org/obo/GO_0044726 GO:0044727 biolink:BiologicalProcess epigenetic programing of male pronucleus The global programming of epigenetic modifications in the male pronucleus of the newly fertilized zygote. The most major change in the paternal genome is DNA demethylation, which takes place before the first cell division. go.json DNA demethylation of male pronucleus|epigenetic reprograming of male pronucleus|epigenetic reprograming of paternal genome in zygote http://purl.obolibrary.org/obo/GO_0044727 GO:0030191 biolink:MolecularActivity obsolete Hsp70/Hsc70 protein inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class. go.json Hsp70/Hsc70 protein inhibitor activity True http://purl.obolibrary.org/obo/GO_0030191 GO:0044724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044724 GO:0044725 biolink:BiologicalProcess epigenetic programming in the zygotic pronuclei The global programming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process. go.json chromatin reprogramming in the zygote http://purl.obolibrary.org/obo/GO_0044725 GO:0044722 biolink:BiologicalProcess renal phosphate excretion The elimination of phosphate ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. go.json renal phosphate ion excretion http://purl.obolibrary.org/obo/GO_0044722 GO:0044723 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044723 GO:0030198 biolink:BiologicalProcess extracellular matrix organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. go.json extracellular matrix organisation|extracellular matrix organization and biogenesis http://purl.obolibrary.org/obo/GO_0030198 goslim_chembl|goslim_drosophila|goslim_generic GO:0030199 biolink:BiologicalProcess collagen fibril organization Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. go.json collagen fibril organisation|fibrillar collagen organization http://purl.obolibrary.org/obo/GO_0030199 GO:0030196 biolink:MolecularActivity cyanide hydratase activity Catalysis of the reaction: formamide = H2O + hydrogen cyanide. EC:4.2.1.66|KEGG_REACTION:R01408|MetaCyc:CYANIDE-HYDRATASE-RXN|RHEA:21720 go.json formamide dehydratase activity|formamide hydro-lyase (cyanide-forming)|formamide hydro-lyase activity http://purl.obolibrary.org/obo/GO_0030196 GO:0030197 biolink:MolecularActivity extracellular matrix constituent, lubricant activity Functions as a lubricant for an extracellular matrix, such as a mucous membrane. go.json core extracellular matrix|core matrisome http://purl.obolibrary.org/obo/GO_0030197 GO:0030194 biolink:BiologicalProcess positive regulation of blood coagulation Any process that activates or increases the frequency, rate or extent of blood coagulation. go.json activation of blood coagulation|stimulation of blood coagulation|up regulation of blood coagulation|up-regulation of blood coagulation|upregulation of blood coagulation http://purl.obolibrary.org/obo/GO_0030194 GO:0030195 biolink:BiologicalProcess negative regulation of blood coagulation Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. go.json down regulation of blood coagulation|down-regulation of blood coagulation|downregulation of blood coagulation|inhibition of blood coagulation http://purl.obolibrary.org/obo/GO_0030195 GO:0044731 biolink:CellularComponent Ost-alpha/Ost-beta complex A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity. go.json (Ost)2 complex|Ost alpha-Ost beta complex|SLC51 complex http://purl.obolibrary.org/obo/GO_0044731 GO:0044732 biolink:CellularComponent mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome. go.json http://purl.obolibrary.org/obo/GO_0044732 GO:0044730 biolink:MolecularActivity bone sialoprotein binding Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin. InterPro:IPR008412 go.json bone sialoprotein II binding http://purl.obolibrary.org/obo/GO_0044730 GO:0030181 biolink:BiologicalProcess obsolete sodium:calcium exchange OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell. go.json sodium:calcium exchange True http://purl.obolibrary.org/obo/GO_0030181 GO:0044739 biolink:BiologicalProcess positive regulation of acid-sensing ion channel in another organism Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism. go.json positive regulation of ASIC channel in other organism|positive regulation of acid-sensing ion channel in other organism http://purl.obolibrary.org/obo/GO_0044739 GO:0030182 biolink:BiologicalProcess neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron. go.json http://purl.obolibrary.org/obo/GO_0030182 GO:0044737 biolink:BiologicalProcess modulation of acid-sensing ion channel in another organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism. go.json modulation of acid-sensing ion channel in other organism|regulation of ASIC channel in other organism|regulation of acid-sensing ion channel in other organism http://purl.obolibrary.org/obo/GO_0044737 GO:0044738 biolink:BiologicalProcess negative regulation of acid-sensing ion channel in another organism Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism. go.json negative regulation of ASIC channel in other organism|negative regulation of acid-sensing ion channel in other organism http://purl.obolibrary.org/obo/GO_0044738 GO:0030180 biolink:BiologicalProcess obsolete solute:solute exchange OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction. go.json solute:solute exchange True http://purl.obolibrary.org/obo/GO_0030180 GO:0044735 biolink:BiologicalProcess envenomation resulting in negative regulation of acid-sensing ion channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. go.json envenomation resulting in negative regulation of ASIC channel activity in other organism|envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism http://purl.obolibrary.org/obo/GO_0044735 GO:0044736 biolink:MolecularActivity acid-sensing ion channel activity Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex. Reactome:R-HSA-2671885|Wikipedia:Acid-sensing_ion_channel go.json ASIC activity http://purl.obolibrary.org/obo/GO_0044736 GO:0044733 biolink:BiologicalProcess envenomation resulting in modulation of acid-sensing ion channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. go.json envenomation resulting in modulation of ASIC channel activity in other organism|envenomation resulting in modulation of acid-sensing ion channel activity in other organism http://purl.obolibrary.org/obo/GO_0044733 GO:0044734 biolink:BiologicalProcess envenomation resulting in positive regulation of acid-sensing ion channel activity in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. go.json envenomation resulting in positive regulation of ASIC channel activity in other organism|envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism http://purl.obolibrary.org/obo/GO_0044734 GO:0030189 biolink:MolecularActivity obsolete chaperone activator activity OBSOLETE. Increases the activity of a molecular chaperone. go.json chaperone activator activity True http://purl.obolibrary.org/obo/GO_0030189 GO:0030187 biolink:BiologicalProcess melatonin biosynthetic process The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). go.json melatonin anabolism|melatonin biosynthesis|melatonin formation|melatonin synthesis http://purl.obolibrary.org/obo/GO_0030187 GO:0030188 biolink:MolecularActivity obsolete chaperone regulator activity OBSOLETE. Modulates the activity of a molecular chaperone. go.json chaperone regulator activity True http://purl.obolibrary.org/obo/GO_0030188 GO:0030185 biolink:BiologicalProcess nitric oxide transport The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0030185 GO:0030186 biolink:BiologicalProcess melatonin metabolic process The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). go.json melatonin metabolism http://purl.obolibrary.org/obo/GO_0030186 GO:0030183 biolink:BiologicalProcess B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. go.json B cell development|B lymphocyte differentiation|B-cell differentiation|B-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0030183 GO:0030184 biolink:MolecularActivity nitric oxide transmembrane transporter activity Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0030184 GO:0044742 biolink:BiologicalProcess envenomation resulting in modulation of sensory perception of pain in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism. go.json envenomation resulting in modulation of sensory perception of pain in other organism|envenomation resulting in regulation of sensory perception of pain in other organism http://purl.obolibrary.org/obo/GO_0044742 GO:0044743 biolink:BiologicalProcess protein transmembrane import into intracellular organelle The directed movement of proteins into an intracellular organelle, across a membrane. go.json http://purl.obolibrary.org/obo/GO_0044743 GO:0044740 biolink:BiologicalProcess negative regulation of sensory perception of pain in another organism A process that negatively regulates the sensory perception of pain in a different organism. go.json inhibition of sensory perception of pain in another organism|negative regulation of sensory perception of pain in other organism http://purl.obolibrary.org/obo/GO_0044740 GO:0044741 biolink:BiologicalProcess envenomation resulting in negative regulation of sensory perception of pain in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism. go.json envenomation resulting in inhibition of sensory perception of pain in other organism|envenomation resulting in negative regulation of sensory perception of pain in other organism http://purl.obolibrary.org/obo/GO_0044741 GO:0030170 biolink:MolecularActivity pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0030170 goslim_metagenomics GO:0030171 biolink:MolecularActivity voltage-gated proton channel activity Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage gated proton channel activity|voltage-dependent proton channel activity http://purl.obolibrary.org/obo/GO_0030171 GO:0044748 biolink:MolecularActivity 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA. go.json exonucleolytic trimming to generate 3' end of miRNA http://purl.obolibrary.org/obo/GO_0044748 GO:0044749 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044749 GO:0044746 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044746 GO:0044747 biolink:BiologicalProcess pre-miRNA 3'-end processing Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends. go.json mature miRNA 3'-end processing|miRNA 3' end terminal trimming|miRNA 3'-end processing|miRNA trimming http://purl.obolibrary.org/obo/GO_0044747 GO:0044744 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044744 GO:0044745 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044745 GO:0030178 biolink:BiologicalProcess negative regulation of Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. go.json down regulation of Wnt receptor signaling pathway|down regulation of frizzled signaling pathway|down-regulation of Wnt receptor signaling pathway|down-regulation of frizzled signaling pathway|downregulation of Wnt receptor signaling pathway|downregulation of frizzled signaling pathway|inhibition of Wnt receptor signaling pathway|inhibition of frizzled signaling pathway|negative regulation of Wnt receptor signaling pathway|negative regulation of Wnt receptor signalling pathway|negative regulation of Wnt-activated signaling pathway|negative regulation of frizzled signaling pathway|negative regulation of frizzled signalling pathway http://purl.obolibrary.org/obo/GO_0030178 GO:0030179 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030179 GO:0030176 biolink:CellularComponent obsolete integral component of endoplasmic reticulum membrane OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json ER integral membrane protein|integral to ER membrane|integral to endoplasmic reticulum membrane True http://purl.obolibrary.org/obo/GO_0030176 GO:0030177 biolink:BiologicalProcess positive regulation of Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. go.json activation of Wnt receptor signaling pathway|activation of frizzled signaling pathway|positive regulation of Wnt receptor signaling pathway|positive regulation of Wnt receptor signalling pathway|positive regulation of Wnt-activated signaling pathway|positive regulation of frizzled signaling pathway|positive regulation of frizzled signalling pathway|stimulation of Wnt receptor signaling pathway|stimulation of frizzled signaling pathway|up regulation of Wnt receptor signaling pathway|up regulation of frizzled signaling pathway|up-regulation of Wnt receptor signaling pathway|up-regulation of frizzled signaling pathway|upregulation of Wnt receptor signaling pathway|upregulation of frizzled signaling pathway http://purl.obolibrary.org/obo/GO_0030177 GO:0030174 biolink:BiologicalProcess regulation of DNA-templated DNA replication initiation Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. go.json DNA replication licencing|DNA replication licensing|regulation of DNA replication initiation|regulation of DNA-dependent DNA replication initiation http://purl.obolibrary.org/obo/GO_0030174 GO:0030175 biolink:CellularComponent filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. NIF_Subcellular:sao1046371754|Wikipedia:Filopodia go.json http://purl.obolibrary.org/obo/GO_0030175 goslim_pir GO:0030172 biolink:MolecularActivity troponin C binding Binding to troponin C, the calcium-binding subunit of the troponin complex. go.json http://purl.obolibrary.org/obo/GO_0030172 GO:0030173 biolink:CellularComponent obsolete integral component of Golgi membrane OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json Golgi integral membrane protein|integral to Golgi membrane True http://purl.obolibrary.org/obo/GO_0030173 GO:0030169 biolink:MolecularActivity low-density lipoprotein particle binding Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. go.json LDL binding http://purl.obolibrary.org/obo/GO_0030169 goslim_chembl GO:0044753 biolink:CellularComponent amphisome Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes. go.json http://purl.obolibrary.org/obo/GO_0044753 GO:0044754 biolink:CellularComponent autolysosome A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases. NIF_Subcellular:sao8444068431 go.json AVd|autophagolysosome|degrading autophagic vacuole http://purl.obolibrary.org/obo/GO_0044754 GO:0044751 biolink:BiologicalProcess cellular response to human chorionic gonadotropin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. go.json cellular response to human chorionic gonadotrophin stimulus http://purl.obolibrary.org/obo/GO_0044751 GO:0044752 biolink:BiologicalProcess response to human chorionic gonadotropin Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. go.json response to human chorionic gonadotropin stimulus http://purl.obolibrary.org/obo/GO_0044752 GO:0044750 biolink:MolecularActivity high-affinity nickel cation transmembrane transporter activity Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json http://purl.obolibrary.org/obo/GO_0044750 GO:0030160 biolink:MolecularActivity synaptic receptor adaptor activity The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule. go.json GKAP/Homer scaffold activity|GKAP/Homer scaffold protein|postsynaptic density scaffold protein http://purl.obolibrary.org/obo/GO_0030160 GO:0044759 biolink:BiologicalProcess negative regulation by symbiont of host synaptic transmission Any process in which a symbiont organism decreases the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. go.json http://purl.obolibrary.org/obo/GO_0044759 GO:0044757 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044757 GO:0044758 biolink:BiologicalProcess modulation by symbiont of host synaptic transmission Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. go.json regulation by symbiont of host synaptic transmission http://purl.obolibrary.org/obo/GO_0044758 GO:0044755 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044755 GO:0044756 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044756 GO:0030167 biolink:BiologicalProcess proteoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. go.json proteoglycan breakdown|proteoglycan catabolism|proteoglycan degradation http://purl.obolibrary.org/obo/GO_0030167 GO:0030168 biolink:BiologicalProcess platelet activation A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. go.json blood coagulation, platelet activation http://purl.obolibrary.org/obo/GO_0030168 GO:0030165 biolink:MolecularActivity PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. go.json DHR-domain binding|GLGF-domain binding http://purl.obolibrary.org/obo/GO_0030165 GO:0030166 biolink:BiologicalProcess proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. go.json proteoglycan anabolism|proteoglycan biosynthesis|proteoglycan formation|proteoglycan synthesis http://purl.obolibrary.org/obo/GO_0030166 GO:0030163 biolink:BiologicalProcess protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. Wikipedia:Protein_catabolism go.json cellular protein breakdown|cellular protein catabolic process|cellular protein catabolism|cellular protein degradation|multicellular organismal protein catabolic process|pheromone catabolic process|pheromone catabolism|protein breakdown|protein catabolism|protein degradation http://purl.obolibrary.org/obo/GO_0030163 goslim_candida|goslim_drosophila|goslim_generic|goslim_pombe|prokaryote_subset GO:0030164 biolink:BiologicalProcess protein denaturation Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds. Wikipedia:Denaturation#Protein_denaturation go.json http://purl.obolibrary.org/obo/GO_0030164 GO:0030161 biolink:MolecularActivity obsolete calpain inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue. go.json calpain inhibitor activity True http://purl.obolibrary.org/obo/GO_0030161 GO:0030162 biolink:BiologicalProcess regulation of proteolysis Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. go.json regulation of peptidolysis http://purl.obolibrary.org/obo/GO_0030162 GO:0030158 biolink:MolecularActivity protein xylosyltransferase activity Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. EC:2.4.2.26|MetaCyc:2.4.2.26-RXN|RHEA:50192|Reactome:R-HSA-1878002 go.json UDP-D-xylose:core protein beta-D-xylosyltransferase activity|UDP-D-xylose:core protein xylosyltransferase activity|UDP-D-xylose:protein beta-D-xylosyltransferase activity|UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity|UDP-xylose-core protein beta-D-xylosyltransferase activity|peptide O-xylosyltransferase activity|uridine diphosphoxylose-core protein beta-xylosyltransferase activity|uridine diphosphoxylose-protein xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0030158 GO:0030159 biolink:MolecularActivity signaling receptor complex adaptor activity The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. go.json receptor signaling complex adaptor activity|receptor signaling complex scaffold activity|receptor signaling complex scaffold protein activity|receptor signalling complex adaptor activity|receptor signalling complex scaffold activity http://purl.obolibrary.org/obo/GO_0030159 GO:0044764 biolink:BiologicalProcess obsolete multi-organism cellular process OBSOLETE. Any process that is carried out at the cellular level which involves another organism of the same or different species. go.json True http://purl.obolibrary.org/obo/GO_0044764 GO:0044765 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044765 GO:0005198 biolink:MolecularActivity structural molecule activity The action of a molecule that contributes to the structural integrity of a complex. go.json http://purl.obolibrary.org/obo/GO_0005198 goslim_agr|goslim_candida|goslim_chembl|goslim_flybase_ribbon|goslim_generic|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0044762 biolink:BiologicalProcess negative regulation by symbiont of host neurotransmitter secretion Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism. go.json http://purl.obolibrary.org/obo/GO_0044762 GO:0044763 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044763 GO:0005199 biolink:MolecularActivity structural constituent of cell wall The action of a molecule that contributes to the structural integrity of a cell wall. go.json http://purl.obolibrary.org/obo/GO_0005199 GO:0044760 biolink:BiologicalProcess modulation by symbiont of host cholinergic synaptic transmission Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism. go.json regulation by symbiont of host cholinergic synaptic transmission http://purl.obolibrary.org/obo/GO_0044760 GO:0044761 biolink:BiologicalProcess negative regulation by symbiont of host cholinergic synaptic transmission Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism. go.json http://purl.obolibrary.org/obo/GO_0044761 GO:0005194 biolink:MolecularActivity obsolete cell adhesion molecule activity OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix. go.json cell adhesion molecule activity True http://purl.obolibrary.org/obo/GO_0005194 GO:0044768 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044768 GO:0044769 biolink:MolecularActivity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism. go.json http://purl.obolibrary.org/obo/GO_0044769 GO:0044766 biolink:BiologicalProcess obsolete multi-organism transport OBSOLETE. The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. go.json True http://purl.obolibrary.org/obo/GO_0044766 GO:0044767 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044767 GO:0030156 biolink:MolecularActivity benzodiazepine receptor binding Binding to a peripheral benzodiazepine receptor (PBR). go.json benzodiazepine receptor ligand|diazepam binding inhibitor activity http://purl.obolibrary.org/obo/GO_0030156 GO:0030157 biolink:BiologicalProcess pancreatic juice secretion The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. go.json http://purl.obolibrary.org/obo/GO_0030157 GO:0030154 biolink:BiologicalProcess cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. Wikipedia:Cellular_differentiation go.json http://purl.obolibrary.org/obo/GO_0030154 goslim_agr|goslim_chembl|goslim_drosophila|goslim_generic|goslim_mouse|goslim_plant GO:0030155 biolink:BiologicalProcess regulation of cell adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. go.json cell adhesion receptor regulator activity http://purl.obolibrary.org/obo/GO_0030155 GO:0030152 biolink:BiologicalProcess bacteriocin biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. go.json bacteriocin anabolism|bacteriocin biosynthesis|bacteriocin formation|bacteriocin synthesis http://purl.obolibrary.org/obo/GO_0030152 GO:0030153 biolink:BiologicalProcess bacteriocin immunity A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. go.json http://purl.obolibrary.org/obo/GO_0030153 GO:0030150 biolink:BiologicalProcess protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. go.json mitochondrial matrix protein import|mitochondrial translocation|protein transport into mitochondrial matrix http://purl.obolibrary.org/obo/GO_0030150 GO:0030151 biolink:MolecularActivity molybdenum ion binding Binding to a molybdenum ion (Mo). go.json Mo ion binding|molybdenum binding http://purl.obolibrary.org/obo/GO_0030151 GO:0030149 biolink:BiologicalProcess sphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). go.json sphingolipid breakdown|sphingolipid catabolism|sphingolipid degradation http://purl.obolibrary.org/obo/GO_0030149 GO:0030147 biolink:BiologicalProcess obsolete natriuresis OBSOLETE. The process of renal sodium excretion. Wikipedia:Natriuresis go.json natriuresis True http://purl.obolibrary.org/obo/GO_0030147 GO:0030148 biolink:BiologicalProcess sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). MetaCyc:PWY-5129 go.json sphingolipid anabolism|sphingolipid biosynthesis|sphingolipid formation|sphingolipid synthesis http://purl.obolibrary.org/obo/GO_0030148 GO:0044775 biolink:CellularComponent DNA polymerase III, beta sliding clamp processivity factor complex A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species. go.json http://purl.obolibrary.org/obo/GO_0044775 GO:0044776 biolink:CellularComponent DNA polymerase III, core complex The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities. go.json http://purl.obolibrary.org/obo/GO_0044776 GO:0044773 biolink:BiologicalProcess mitotic DNA damage checkpoint signaling A signal transduction process involved in mitotic DNA damage checkpoint. go.json intracellular signal transduction pathway involved in mitotic DNA damage checkpoint|intracellular signaling cascade involved in mitotic DNA damage checkpoint|intracellular signaling pathway involved in mitotic DNA damage checkpoint|mitotic DNA damage checkpoint|signal transduction involved in mitotic DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0044773 GO:0044774 biolink:BiologicalProcess mitotic DNA integrity checkpoint signaling A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. go.json intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signal transduction involved in topo II checkpoint|intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint|intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signal transduction pathway involved in topo II checkpoint|intracellular signal transduction pathway involved in topoisomerase II checkpoint|intracellular signaling cascade involved in mitotic DNA integrity checkpoint|intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signaling cascade involved in topo II checkpoint|intracellular signaling chain involved in mitotic DNA integrity checkpoint|intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signaling pathway involved in mitotic DNA integrity checkpoint|intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signaling pathway involved in topo II checkpoint|intracellular signaling pathway involved in topoisomerase II checkpoint|mitotic DNA integrity checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint|signal transduction involved in mitotic DNA integrity checkpoint|signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint|signal transduction via intracellular signaling cascade involved in topo II checkpoint http://purl.obolibrary.org/obo/GO_0044774 GO:0044771 biolink:BiologicalProcess meiotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase. go.json cell cycle transition http://purl.obolibrary.org/obo/GO_0044771 GO:0044772 biolink:BiologicalProcess mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. go.json http://purl.obolibrary.org/obo/GO_0044772 goslim_pombe GO:0044770 biolink:BiologicalProcess cell cycle phase transition The cell cycle process by which a cell commits to entering the next cell cycle phase. go.json cell cycle transition http://purl.obolibrary.org/obo/GO_0044770 GO:0044779 biolink:BiologicalProcess meiotic spindle checkpoint signaling A signal transduction process that contributes to a cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle. go.json intracellular signal transduction involved in meiotic spindle checkpoint|intracellular signal transduction pathway involved in meiotic spindle checkpoint|intracellular signaling cascade involved in meiotic spindle checkpoint|intracellular signaling pathway involved in meiotic spindle checkpoint|meiotic spindle checkpoint http://purl.obolibrary.org/obo/GO_0044779 GO:0044777 biolink:CellularComponent single-stranded DNA-binding protein complex A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair. go.json SSB complex http://purl.obolibrary.org/obo/GO_0044777 GO:0044778 biolink:BiologicalProcess meiotic DNA integrity checkpoint signaling A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. go.json meiotic DNA integrity checkpoint http://purl.obolibrary.org/obo/GO_0044778 GO:0030145 biolink:MolecularActivity manganese ion binding Binding to a manganese ion (Mn). go.json Mn binding|manganese binding http://purl.obolibrary.org/obo/GO_0030145 GO:0030146 biolink:BiologicalProcess obsolete diuresis OBSOLETE. The process of renal water excretion. Wikipedia:Diuresis go.json diuresis|positive regulation of renal water excretion|renal water excretion True http://purl.obolibrary.org/obo/GO_0030146 GO:0030143 biolink:CellularComponent COPI-coated inter-Golgi transport vesicle A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack). NIF_Subcellular:sao1382918459 go.json inter-Golgi transport constitutive secretory pathway transport vesicle http://purl.obolibrary.org/obo/GO_0030143 GO:0030144 biolink:MolecularActivity alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. EC:2.4.1.155|MetaCyc:2.4.1.155-RXN|RHEA:16921|Reactome:R-HSA-9696980|Reactome:R-HSA-975916 go.json GnTV activity|N-acetylglucosaminyltransferase V activity|UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity|UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity|alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0030144 GO:0030141 biolink:CellularComponent secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. go.json secretory vesicle http://purl.obolibrary.org/obo/GO_0030141 GO:0030142 biolink:CellularComponent COPI-coated Golgi to ER transport vesicle A vesicle that mediates transport from the Golgi to the endoplasmic reticulum. go.json Golgi to ER constitutive secretory pathway transport vesicle|Golgi to endoplasmic reticulum transport vesicle|Golgi-ER transport vesicle|Golgi-endoplasmic reticulum transport vesicle|retrograde transport vesicle http://purl.obolibrary.org/obo/GO_0030142 GO:0030140 biolink:CellularComponent trans-Golgi network transport vesicle A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. go.json TGN transport vesicle|trans-Golgi network constitutive secretory pathway transport vesicle http://purl.obolibrary.org/obo/GO_0030140 GO:0019739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019739 GO:0019737 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019737 GO:0019738 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019738 GO:0019735 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019735 GO:0019736 biolink:BiologicalProcess peptidyl-sarcosine incorporation The incorporation of sarcosine (N-methylglycine) into non-coded peptides. RESID:AA0063 go.json http://purl.obolibrary.org/obo/GO_0019736 gocheck_do_not_annotate GO:0019733 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019733 GO:0019734 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019734 GO:0019731 biolink:BiologicalProcess antibacterial humoral response An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0019731 GO:0019732 biolink:BiologicalProcess antifungal humoral response An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0019732 GO:0019730 biolink:BiologicalProcess antimicrobial humoral response An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0019730 GO:0005109 biolink:MolecularActivity frizzled binding Binding to a frizzled (fz) receptor. go.json frizzled ligand|frizzled-2 binding|frizzled-2 ligand|fz binding|fz ligand|fz2 binding|fz2 ligand http://purl.obolibrary.org/obo/GO_0005109 goslim_chembl GO:0005107 biolink:MolecularActivity obsolete GPI-linked ephrin OBSOLETE. (Was not defined before being made obsolete). go.json GPI-linked ephrin True http://purl.obolibrary.org/obo/GO_0005107 GO:0005108 biolink:MolecularActivity obsolete transmembrane ephrin OBSOLETE. (Was not defined before being made obsolete). go.json transmembrane ephrin True http://purl.obolibrary.org/obo/GO_0005108 GO:0005105 biolink:MolecularActivity type 1 fibroblast growth factor receptor binding Binding to a type 1 fibroblast growth factor receptor (FGFR1). go.json FGFR1 binding|FGFR1 ligand|breathless binding|breathless ligand|type 1 fibroblast growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005105 GO:0005106 biolink:MolecularActivity obsolete ephrin OBSOLETE. A class of proteins that interact with the ephrin receptors. go.json ephrin True http://purl.obolibrary.org/obo/GO_0005106 GO:0005103 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005103 GO:0005104 biolink:MolecularActivity fibroblast growth factor receptor binding Binding to a fibroblast growth factor receptor (FGFR). go.json FGF receptor binding|FGFR binding|FGFR ligand|fibroblast growth factor|fibroblast growth factor receptor ligand http://purl.obolibrary.org/obo/GO_0005104 GO:0005101 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005101 GO:0005102 biolink:MolecularActivity signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. Wikipedia:Ligand_(biochemistry) go.json receptor binding|receptor ligand|receptor-associated protein activity http://purl.obolibrary.org/obo/GO_0005102 goslim_agr|goslim_chembl|goslim_flybase_ribbon|goslim_mouse|goslim_plant GO:0005100 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005100 GO:0019748 biolink:BiologicalProcess secondary metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. Wikipedia:Secondary_metabolism go.json secondary metabolism|secondary metabolite metabolic process|secondary metabolite metabolism http://purl.obolibrary.org/obo/GO_0019748 goslim_chembl|goslim_pir|goslim_plant|goslim_pombe GO:0019749 biolink:BiologicalProcess cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte. go.json http://purl.obolibrary.org/obo/GO_0019749 GO:0019746 biolink:BiologicalProcess hopanoid biosynthetic process The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. go.json hopanoid anabolism|hopanoid biosynthesis|hopanoid formation|hopanoid synthesis http://purl.obolibrary.org/obo/GO_0019746 GO:0019747 biolink:BiologicalProcess regulation of isoprenoid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids. go.json regulation of isoprenoid metabolism http://purl.obolibrary.org/obo/GO_0019747 GO:0019744 biolink:BiologicalProcess hopanoid metabolic process The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. go.json hopanoid metabolism http://purl.obolibrary.org/obo/GO_0019744 GO:0019745 biolink:BiologicalProcess pentacyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. go.json pentacyclic triterpenoid anabolism|pentacyclic triterpenoid biosynthesis|pentacyclic triterpenoid formation|pentacyclic triterpenoid synthesis http://purl.obolibrary.org/obo/GO_0019745 GO:0019742 biolink:BiologicalProcess pentacyclic triterpenoid metabolic process The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. go.json pentacyclic triterpenoid metabolism http://purl.obolibrary.org/obo/GO_0019742 GO:0019743 biolink:BiologicalProcess hopanoid catabolic process The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. go.json hopanoid breakdown|hopanoid catabolism|hopanoid degradation http://purl.obolibrary.org/obo/GO_0019743 GO:0019740 biolink:BiologicalProcess nitrogen utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. go.json http://purl.obolibrary.org/obo/GO_0019740 GO:0019741 biolink:BiologicalProcess pentacyclic triterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. go.json pentacyclic triterpenoid breakdown|pentacyclic triterpenoid catabolism|pentacyclic triterpenoid degradation http://purl.obolibrary.org/obo/GO_0019741 GO:0019719 biolink:CellularComponent obsolete smooth microsome OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes. go.json smooth microsome True http://purl.obolibrary.org/obo/GO_0019719 GO:0019717 biolink:CellularComponent obsolete synaptosome OBSOLETE. Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma. Wikipedia:Synaptosome go.json synaptosome True http://purl.obolibrary.org/obo/GO_0019717 GO:0019718 biolink:CellularComponent obsolete rough microsome OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside. go.json rough microsome True http://purl.obolibrary.org/obo/GO_0019718 GO:0019715 biolink:BiologicalProcess peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). RESID:AA0027 go.json http://purl.obolibrary.org/obo/GO_0019715 gocheck_do_not_annotate GO:0019716 biolink:BiologicalProcess N-terminal peptidyl-alanine monomethylation The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine. RESID:AA0061 go.json http://purl.obolibrary.org/obo/GO_0019716 gocheck_do_not_annotate GO:0019713 biolink:BiologicalProcess obsolete peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine OBSOLETE. The coupled methyl esterification and deamidation of peptidyl-glutamine. go.json peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine|peptidyl-L-glutamic acid 5-methyl ester formation from glutamine|peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine True http://purl.obolibrary.org/obo/GO_0019713 GO:0019714 biolink:BiologicalProcess obsolete peptidyl-glutamine esterification OBSOLETE. The addition of an ester group to a glutamine residue in a protein. go.json True http://purl.obolibrary.org/obo/GO_0019714 GO:0019711 biolink:BiologicalProcess peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid. go.json peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid|peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid|peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid http://purl.obolibrary.org/obo/GO_0019711 gocheck_do_not_annotate GO:0019712 biolink:BiologicalProcess obsolete peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid OBSOLETE. The methyl esterification of peptidyl-glutamic acid. go.json peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid|peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid|peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid True http://purl.obolibrary.org/obo/GO_0019712 GO:0019710 biolink:BiologicalProcess obsolete peptidyl-asparagine methylation OBSOLETE. The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine. go.json True http://purl.obolibrary.org/obo/GO_0019710 GO:0019728 biolink:BiologicalProcess peptidyl-allysine oxidation to 2-aminoadipic acid The oxidation of allysine to 2-aminoadipic acid. RESID:AA0370 go.json http://purl.obolibrary.org/obo/GO_0019728 gocheck_do_not_annotate GO:0019729 biolink:BiologicalProcess obsolete peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine OBSOLETE. The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. RESID:AA0189 go.json biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0019729 GO:0019726 biolink:MolecularActivity obsolete mevaldate reductase (NADPH) activity OBSOLETE. Catalysis of the reaction: (R)-mevalonate + NADP+ = H+ + mevaldate + NADPH. go.json (R)-mevalonate:NADP+ oxidoreductase|mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase True http://purl.obolibrary.org/obo/GO_0019726 GO:0019727 biolink:MolecularActivity mevaldate reductase (NAD+) activity Catalysis of the reaction: (R)-mevalonate + NAD+ = H+ + mevaldate + NADH. EC:1.1.1.32|KEGG_REACTION:R02246|MetaCyc:MEVALDATE-REDUCTASE-RXN|RHEA:13221 go.json http://purl.obolibrary.org/obo/GO_0019727 GO:0019724 biolink:BiologicalProcess B cell mediated immunity Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. go.json B lymphocyte mediated immune effector process|B lymphocyte mediated immunity|B-cell mediated immune effector process|B-cell mediated immunity|B-lymphocyte mediated immune effector process|B-lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0019724 GO:0019725 biolink:BiologicalProcess cellular homeostasis Any process involved in the maintenance of an internal steady state at the level of the cell. go.json http://purl.obolibrary.org/obo/GO_0019725 goslim_candida|goslim_plant GO:0019722 biolink:BiologicalProcess calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. Wikipedia:Calcium_signaling go.json calcium ion signaling|calcium signaling|calcium signalling|calcium-mediated signalling http://purl.obolibrary.org/obo/GO_0019722 GO:0019723 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019723 GO:0019720 biolink:BiologicalProcess Mo-molybdopterin cofactor metabolic process The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. go.json Mo-molybdopterin cofactor metabolism|Moco metabolic process|Moco metabolism http://purl.obolibrary.org/obo/GO_0019720 GO:0019721 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019721 GO:0019708 biolink:BiologicalProcess peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins. RESID:AA0309 go.json peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine|peptidyl-glycine cholesteryl ester formation from peptidyl-glycine|peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine http://purl.obolibrary.org/obo/GO_0019708 gocheck_do_not_annotate GO:0019709 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. RESID:AA0310 go.json iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide http://purl.obolibrary.org/obo/GO_0019709 gocheck_do_not_annotate GO:0019706 biolink:MolecularActivity protein-cysteine S-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]. EC:2.3.1.225|RHEA:36683|Reactome:R-HSA-5682084|Reactome:R-HSA-9021072|Reactome:R-HSA-9647982|Reactome:R-HSA-9694341 go.json protein-cysteine S-palmitoleyltransferase activity http://purl.obolibrary.org/obo/GO_0019706 GO:0019707 biolink:MolecularActivity protein-cysteine S-acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. RHEA:63372 go.json http://purl.obolibrary.org/obo/GO_0019707 GO:0019704 biolink:BiologicalProcess peptidyl-L-cysteine S-myristoylation The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine. RESID:AA0307 go.json peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine|peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0019704 gocheck_do_not_annotate GO:0019705 biolink:MolecularActivity protein-cysteine S-myristoyltransferase activity Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]. RHEA:59736 go.json http://purl.obolibrary.org/obo/GO_0019705 GO:0019702 biolink:MolecularActivity protein arginine N5-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine. EC:2.1.1.322|RHEA:48116 go.json S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)|protein arginine N5-methylase activity|protein-arginine N5-methyltransferase activity|protein-arginine delta-N-methyltransferase activity|type IV PRMT activity|type IV protein arginine methyltransferase activity http://purl.obolibrary.org/obo/GO_0019702 GO:0019703 biolink:BiologicalProcess coenzyme A-peptidyl-cysteine covalent linking The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide. RESID:AA0306 go.json http://purl.obolibrary.org/obo/GO_0019703 gocheck_do_not_annotate GO:0019700 biolink:BiologicalProcess organic phosphonate catabolic process The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. go.json organophosphonate catabolic process|phosphonate breakdown|phosphonate catabolism|phosphonate degradation http://purl.obolibrary.org/obo/GO_0019700 GO:0019701 biolink:BiologicalProcess peptidyl-arginine N5-methylation The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine. RESID:AA0305 go.json peptidyl-arginine delta-N-methylation http://purl.obolibrary.org/obo/GO_0019701 gocheck_do_not_annotate RO:0002180 biolink:OntologyClass has component RO:0002180 go.json http://purl.obolibrary.org/obo/RO_0002180 GO:0030259 biolink:BiologicalProcess lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. go.json http://purl.obolibrary.org/obo/GO_0030259 GO:0030257 biolink:CellularComponent type III protein secretion system complex A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. go.json T3SS complex|TTSS complex http://purl.obolibrary.org/obo/GO_0030257 GO:0030258 biolink:BiologicalProcess lipid modification The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. go.json http://purl.obolibrary.org/obo/GO_0030258 RO:0002297 biolink:OntologyClass results in formation of RO:0002297 go.json http://purl.obolibrary.org/obo/RO_0002297 GO:0005299 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005299 RO:0002298 biolink:OntologyClass results in morphogenesis of RO:0002298 go.json http://purl.obolibrary.org/obo/RO_0002298 GO:0005297 biolink:MolecularActivity proline:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in). go.json hydrogen/proline transporter http://purl.obolibrary.org/obo/GO_0005297 RO:0002299 biolink:OntologyClass results in maturation of RO:0002299 go.json http://purl.obolibrary.org/obo/RO_0002299 GO:0005298 biolink:MolecularActivity proline:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). RHEA:28967|Reactome:R-HSA-444100 go.json sodium/proline symporter activity http://purl.obolibrary.org/obo/GO_0005298 GO:0005295 biolink:MolecularActivity neutral L-amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in). go.json neutral amino acid-sodium cotransporter|neutral amino acid:sodium symporter activity|sodium/neutral amino acid transporter http://purl.obolibrary.org/obo/GO_0005295 GO:0005296 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005296 RO:0002295 biolink:OntologyClass results in developmental progression of RO:0002295 go.json http://purl.obolibrary.org/obo/RO_0002295 GO:0005293 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005293 RO:0002296 biolink:OntologyClass results in development of RO:0002296 go.json http://purl.obolibrary.org/obo/RO_0002296 GO:0005294 biolink:MolecularActivity neutral L-amino acid secondary active transmembrane transporter activity Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json neutral L-amino acid porter activity http://purl.obolibrary.org/obo/GO_0005294 GO:0030255 biolink:BiologicalProcess protein secretion by the type IV secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system. go.json protein secretion by the T4SS|protein secretion by the type IV protein secretion system|type IV protein secretion system http://purl.obolibrary.org/obo/GO_0030255 GO:0030256 biolink:CellularComponent type I protein secretion system complex A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space. go.json ABC translocator complex http://purl.obolibrary.org/obo/GO_0030256 GO:0030253 biolink:BiologicalProcess protein secretion by the type I secretion system The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. go.json protein secretion by the TOSS|protein secretion by the type I protein secretion system|type I protein secretion system http://purl.obolibrary.org/obo/GO_0030253 GO:0030254 biolink:BiologicalProcess protein secretion by the type III secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. go.json protein secretion by the T3S|protein secretion by the T3SS|protein secretion by the TTSS|protein secretion by the type III protein secretion system|type III protein secretion system http://purl.obolibrary.org/obo/GO_0030254 GO:0030251 biolink:MolecularActivity guanylate cyclase inhibitor activity Binds to and stops, prevents or reduces the activity of guanylate cyclase. go.json http://purl.obolibrary.org/obo/GO_0030251 GO:0030252 biolink:BiologicalProcess growth hormone secretion The regulated release of growth hormone from secretory granules into the blood. go.json somatotropin secretion http://purl.obolibrary.org/obo/GO_0030252 GO:0030250 biolink:MolecularActivity guanylate cyclase activator activity Binds to and increases the activity of guanylate cyclase. go.json guanylin http://purl.obolibrary.org/obo/GO_0030250 GO:0030248 biolink:MolecularActivity cellulose binding Binding to cellulose. go.json http://purl.obolibrary.org/obo/GO_0030248 GO:0030249 biolink:MolecularActivity guanylate cyclase regulator activity Modulates the activity of guanylate cyclase. go.json http://purl.obolibrary.org/obo/GO_0030249 GO:0030246 biolink:MolecularActivity carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. go.json selectin|sugar binding http://purl.obolibrary.org/obo/GO_0030246 goslim_agr|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_metagenomics|goslim_pir|goslim_plant GO:0030247 biolink:MolecularActivity polysaccharide binding Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json polysaccharide assembly with MHC class II protein complex http://purl.obolibrary.org/obo/GO_0030247 GO:0030244 biolink:BiologicalProcess cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. MetaCyc:PWY-1001 go.json cellulose anabolism|cellulose biosynthesis|cellulose formation|cellulose synthesis http://purl.obolibrary.org/obo/GO_0030244 GO:0030245 biolink:BiologicalProcess cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. go.json cellulose breakdown|cellulose catabolism|cellulose degradation http://purl.obolibrary.org/obo/GO_0030245 GO:0030242 biolink:BiologicalProcess autophagy of peroxisome The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions. go.json peroxisome degradation|peroxisome disassembly|pexophagy http://purl.obolibrary.org/obo/GO_0030242 gocheck_do_not_annotate GO:0030243 biolink:BiologicalProcess cellulose metabolic process The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. go.json cellulose metabolism http://purl.obolibrary.org/obo/GO_0030243 GO:0030240 biolink:BiologicalProcess skeletal muscle thin filament assembly The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle. go.json http://purl.obolibrary.org/obo/GO_0030240 GO:0030241 biolink:BiologicalProcess skeletal muscle myosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle. go.json http://purl.obolibrary.org/obo/GO_0030241 GO:0030239 biolink:BiologicalProcess myofibril assembly Formation of myofibrils, the repeating units of striated muscle. go.json http://purl.obolibrary.org/obo/GO_0030239 GO:0030237 biolink:BiologicalProcess female sex determination The specification of female sex of an individual organism. go.json http://purl.obolibrary.org/obo/GO_0030237 GO:0030238 biolink:BiologicalProcess male sex determination The specification of male sex of an individual organism. go.json http://purl.obolibrary.org/obo/GO_0030238 GO:0005279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005279 GO:0030235 biolink:MolecularActivity nitric-oxide synthase regulator activity Binds to and modulates the activity of nitric oxide synthase. go.json nitric oxide synthase regulator activity http://purl.obolibrary.org/obo/GO_0030235 GO:0030236 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030236 GO:0005277 biolink:MolecularActivity acetylcholine transmembrane transporter activity Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. Reactome:R-HSA-264615 go.json http://purl.obolibrary.org/obo/GO_0005277 GO:0005278 biolink:MolecularActivity acetylcholine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out). go.json acetylcholine:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0005278 GO:0005275 biolink:MolecularActivity amine transmembrane transporter activity Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. go.json amine/amide/polyamine channel activity|amine/polyamine transmembrane transporter activity|amino acid-polyamine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005275 GO:0005276 biolink:MolecularActivity obsolete vesicular amino acid:proton antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in). go.json hydrogen:vesicular amine antiporter activity|vesicular hydrogen:amino acid antiporter activity True http://purl.obolibrary.org/obo/GO_0005276 GO:0005274 biolink:MolecularActivity allantoin:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport. go.json allantoin permease activity|allantoin uptake transmembrane transporter activity|allantoin/allantoate transporter http://purl.obolibrary.org/obo/GO_0005274 GO:0005272 biolink:MolecularActivity sodium channel activity Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Reactome:R-HSA-2730664|Reactome:R-HSA-3295580|Reactome:R-HSA-9717374|Reactome:R-HSA-9717382|Reactome:R-HSA-9717395|Reactome:R-HSA-9717396 go.json http://purl.obolibrary.org/obo/GO_0005272 GO:0005280 biolink:MolecularActivity amino acid:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). Reactome:R-HSA-8875623 go.json cation/amino acid symporter|hydrogen:amino acid symporter activity http://purl.obolibrary.org/obo/GO_0005280 GO:0005281 biolink:MolecularActivity obsolete general amino acid permease activity OBSOLETE. (Was not defined before being made obsolete). go.json general amino acid permease activity|general amino acid transporter True http://purl.obolibrary.org/obo/GO_0005281 GO:0030233 biolink:MolecularActivity deoxynucleotide transmembrane transporter activity Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. go.json http://purl.obolibrary.org/obo/GO_0030233 GO:0030234 biolink:MolecularActivity enzyme regulator activity Binds to and modulates the activity of an enzyme. go.json catalytic regulator activity|enzyme modulator|metalloenzyme regulator activity http://purl.obolibrary.org/obo/GO_0030234 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast GO:0030231 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030231 GO:0030232 biolink:CellularComponent insulin control element activator complex Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription. go.json ICE activator complex http://purl.obolibrary.org/obo/GO_0030232 GO:0030230 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030230 GO:0030228 biolink:MolecularActivity lipoprotein particle receptor activity Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. go.json lipoprotein receptor activity|plasma lipoprotein particle receptor activity http://purl.obolibrary.org/obo/GO_0030228 GO:0030229 biolink:MolecularActivity very-low-density lipoprotein particle receptor activity Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis. Wikipedia:VLDL_receptor go.json VLDL receptor|apolipoprotein E receptor activity|very-low-density lipoprotein receptor activity http://purl.obolibrary.org/obo/GO_0030229 GO:0030226 biolink:MolecularActivity apolipoprotein receptor activity Combining with an apolipoprotein to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0030226 GO:0030227 biolink:MolecularActivity obsolete apolipoprotein E receptor activity OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity. go.json ApoE receptor|apolipoprotein E receptor activity True http://purl.obolibrary.org/obo/GO_0030227 GO:0030224 biolink:BiologicalProcess monocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. go.json monocyte cell differentiation http://purl.obolibrary.org/obo/GO_0030224 GO:0030225 biolink:BiologicalProcess macrophage differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. go.json macrophage cell differentiation http://purl.obolibrary.org/obo/GO_0030225 GO:0005288 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005288 GO:0005289 biolink:MolecularActivity high-affinity L-arginine transmembrane transporter activity Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity arginine transmembrane transporter activity|high-affinity arginine transmembrane transporter activity|high-affinity arginine transporter activity http://purl.obolibrary.org/obo/GO_0005289 GO:0005286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005286 GO:0005287 biolink:MolecularActivity high-affinity basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity basic amino acid transmembrane transporter activity|high-affinity basic amino acid transporter activity http://purl.obolibrary.org/obo/GO_0005287 GO:0005284 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005284 GO:0005285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005285 GO:0005282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005282 GO:0005283 biolink:MolecularActivity amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). go.json glutamate/aspartate:sodium symporter activity|insulin-activated sodium/amino acid transporter activity|insulin-activated sodium:amino acid symporter activity|insulin-activated sodium:amino acid transporter activity|isoleucine/valine:sodium symporter activity|sodium/amino acid transporter activity|sodium/excitatory amino acid cotransporter activity|sodium/excitatory amino acid symporter activity|sodium:amino acid symporter activity|sodium:amino acid transporter activity|threonine/serine:sodium symporter activity http://purl.obolibrary.org/obo/GO_0005283 GO:0005291 biolink:MolecularActivity high-affinity L-histidine transmembrane transporter activity Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity L-histidine transmembrane transporter activity|high affinity histidine permease activity http://purl.obolibrary.org/obo/GO_0005291 GO:0005292 biolink:MolecularActivity high-affinity lysine transmembrane transporter activity Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity lysine transmembrane transporter activity|high affinity lysine transporter activity http://purl.obolibrary.org/obo/GO_0005292 GO:0005290 biolink:MolecularActivity L-histidine transmembrane transporter activity Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. go.json L-histidine transporter activity|histidine/arginine/lysine/ornithine porter activity http://purl.obolibrary.org/obo/GO_0005290 GO:0030222 biolink:BiologicalProcess eosinophil differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil. go.json eosinophil cell development|eosinophil cell differentiation|eosinophil development http://purl.obolibrary.org/obo/GO_0030222 GO:0030223 biolink:BiologicalProcess neutrophil differentiation The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. go.json neutrophil cell differentiation|neutrophil granulocyte differentiation|neutrophil granulocytopoiesis http://purl.obolibrary.org/obo/GO_0030223 GO:0030220 biolink:BiologicalProcess platelet formation The process in which platelets bud from long processes extended by megakaryocytes. go.json platelet extrusion http://purl.obolibrary.org/obo/GO_0030220 GO:0030221 biolink:BiologicalProcess basophil differentiation The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell. go.json basophil cell differentiation http://purl.obolibrary.org/obo/GO_0030221 GO:0030219 biolink:BiologicalProcess megakaryocyte differentiation The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. go.json megakaryocyte cell differentiation http://purl.obolibrary.org/obo/GO_0030219 GO:0030217 biolink:BiologicalProcess T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. go.json T cell development|T lymphocyte differentiation|T-cell differentiation|T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0030217 GO:0030218 biolink:BiologicalProcess erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. Wikipedia:Erythropoiesis go.json RBC differentiation|erythrocyte cell differentiation|erythropoiesis|red blood cell differentiation http://purl.obolibrary.org/obo/GO_0030218 GO:0030215 biolink:MolecularActivity semaphorin receptor binding Binding to a semaphorin receptor. go.json plexin binding|plexin ligand|semaphorin receptor ligand http://purl.obolibrary.org/obo/GO_0030215 GO:0030216 biolink:BiologicalProcess keratinocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. go.json keratinocyte cell differentiation http://purl.obolibrary.org/obo/GO_0030216 GO:0030213 biolink:BiologicalProcess hyaluronan biosynthetic process The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. go.json hyaluronan anabolism|hyaluronan biosynthesis|hyaluronan formation|hyaluronan synthesis http://purl.obolibrary.org/obo/GO_0030213 GO:0030214 biolink:BiologicalProcess hyaluronan catabolic process The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. go.json hyaluronan breakdown|hyaluronan catabolism|hyaluronan degradation http://purl.obolibrary.org/obo/GO_0030214 GO:0005253 biolink:MolecularActivity monoatomic anion channel activity Enables the energy-independent passage of a monoatomic anion across a lipid bilayer down a concentration gradient. Reactome:R-HSA-432034|Reactome:R-HSA-432036 go.json anion channel activity|non-selective anion channel activity http://purl.obolibrary.org/obo/GO_0005253 GO:0005254 biolink:MolecularActivity chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Reactome:R-HSA-2744349|Reactome:R-HSA-427570|Reactome:R-HSA-9712204|Reactome:R-HSA-975340|Reactome:R-HSA-975449 go.json http://purl.obolibrary.org/obo/GO_0005254 GO:0005251 biolink:MolecularActivity delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. Reactome:R-HSA-5577050|Reactome:R-HSA-5577237 go.json http://purl.obolibrary.org/obo/GO_0005251 GO:0005252 biolink:MolecularActivity open rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. go.json http://purl.obolibrary.org/obo/GO_0005252 GO:0005250 biolink:MolecularActivity A-type (transient outward) potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. Reactome:R-HSA-5577234 go.json http://purl.obolibrary.org/obo/GO_0005250 GO:0019898 biolink:CellularComponent extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. Wikipedia:Peripheral_membrane_protein go.json extrinsic to membrane|peripheral membrane protein http://purl.obolibrary.org/obo/GO_0019898 goslim_metagenomics GO:0019899 biolink:MolecularActivity enzyme binding Binding to an enzyme, a protein with catalytic activity. go.json http://purl.obolibrary.org/obo/GO_0019899 goslim_chembl|goslim_yeast GO:0030211 biolink:BiologicalProcess heparin catabolic process The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. go.json heparan sulfate catabolic process|heparin breakdown|heparin catabolism|heparin degradation http://purl.obolibrary.org/obo/GO_0030211 GO:0019896 biolink:BiologicalProcess axonal transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell axons. go.json axon transport of mitochondria http://purl.obolibrary.org/obo/GO_0019896 goslim_synapse GO:0019897 biolink:CellularComponent extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to plasma membrane|juxtamembrane|peripheral plasma membrane protein http://purl.obolibrary.org/obo/GO_0019897 GO:0030212 biolink:BiologicalProcess hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. go.json hyaluronan metabolism http://purl.obolibrary.org/obo/GO_0030212 GO:0019894 biolink:MolecularActivity kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. go.json http://purl.obolibrary.org/obo/GO_0019894 GO:0030210 biolink:BiologicalProcess heparin biosynthetic process The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. go.json heparan sulfate biosynthetic process|heparin anabolism|heparin biosynthesis|heparin formation|heparin synthesis http://purl.obolibrary.org/obo/GO_0030210 GO:0019895 biolink:MolecularActivity obsolete kinesin-associated mitochondrial adaptor activity OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria. go.json True http://purl.obolibrary.org/obo/GO_0019895 GO:0019893 biolink:MolecularActivity obsolete DNA replication inhibitor OBSOLETE. (Was not defined before being made obsolete). go.json DNA replication inhibitor True http://purl.obolibrary.org/obo/GO_0019893 GO:0030208 biolink:BiologicalProcess dermatan sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. go.json chondroitin sulfate B biosynthesis|chondroitin sulfate B biosynthetic process|dermatan sulfate anabolism|dermatan sulfate biosynthesis|dermatan sulfate formation|dermatan sulfate synthesis|dermatan sulphate biosynthesis|dermatan sulphate biosynthetic process http://purl.obolibrary.org/obo/GO_0030208 GO:0030209 biolink:BiologicalProcess dermatan sulfate catabolic process The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. go.json chondroitin sulfate B catabolic process|chondroitin sulfate B catabolism|dermatan sulfate breakdown|dermatan sulfate catabolism|dermatan sulfate degradation|dermatan sulphate catabolic process|dermatan sulphate catabolism http://purl.obolibrary.org/obo/GO_0030209 GO:0030206 biolink:BiologicalProcess chondroitin sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. go.json chondroitin sulfate anabolism|chondroitin sulfate biosynthesis|chondroitin sulfate formation|chondroitin sulfate synthesis|chondroitin sulphate biosynthesis|chondroitin sulphate biosynthetic process http://purl.obolibrary.org/obo/GO_0030206 GO:0030207 biolink:BiologicalProcess chondroitin sulfate catabolic process The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. go.json chondroitin sulfate breakdown|chondroitin sulfate catabolism|chondroitin sulfate degradation|chondroitin sulphate catabolic process|chondroitin sulphate catabolism http://purl.obolibrary.org/obo/GO_0030207 GO:0030204 biolink:BiologicalProcess chondroitin sulfate metabolic process The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate. go.json chondroitin sulfate metabolism|chondroitin sulphate metabolic process|chondroitin sulphate metabolism http://purl.obolibrary.org/obo/GO_0030204 GO:0030205 biolink:BiologicalProcess dermatan sulfate metabolic process The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. go.json chondroitin sulfate B metabolic process|chondroitin sulfate B metabolism|dermatan sulfate metabolism|dermatan sulphate metabolic process|dermatan sulphate metabolism http://purl.obolibrary.org/obo/GO_0030205 GO:0030202 biolink:BiologicalProcess heparin metabolic process The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. go.json heparan sulfate metabolic process|heparin metabolism http://purl.obolibrary.org/obo/GO_0030202 GO:0030203 biolink:BiologicalProcess glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. go.json glycosaminoglycan metabolism http://purl.obolibrary.org/obo/GO_0030203 GO:0005267 biolink:MolecularActivity potassium channel activity Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Reactome:R-HSA-1296024|Reactome:R-HSA-1296035|Reactome:R-HSA-1296037|Reactome:R-HSA-1296039|Reactome:R-HSA-1296348|Reactome:R-HSA-1299297|Reactome:R-HSA-1299304|Reactome:R-HSA-1299318|Reactome:R-HSA-1299338|Reactome:R-HSA-1299359|Reactome:R-HSA-2534365|Reactome:R-HSA-5578910 go.json http://purl.obolibrary.org/obo/GO_0005267 GO:0005262 biolink:MolecularActivity calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Reactome:R-HSA-139854|Reactome:R-HSA-139855|Reactome:R-HSA-210420|Reactome:R-HSA-3295579|Reactome:R-HSA-8949145|Reactome:R-HSA-8949178|Reactome:R-HSA-9663785 go.json http://purl.obolibrary.org/obo/GO_0005262 GO:0005260 biolink:MolecularActivity intracellularly ATP-gated chloride channel activity Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. EC:5.6.1.6|MetaCyc:3.6.3.49-RXN|TC:3.A.1.202.1|Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator go.json CFTR|channel-conductance-controlling ATPase activity|cystic fibrosis transmembrane conductance regulator http://purl.obolibrary.org/obo/GO_0005260 GO:0005261 biolink:MolecularActivity monoatomic cation channel activity Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient. Reactome:R-HSA-1168376|Reactome:R-HSA-1296043|Reactome:R-HSA-169683|Reactome:R-HSA-2089943|Reactome:R-HSA-426223|Reactome:R-HSA-4420052|Reactome:R-HSA-9706720|Reactome:R-HSA-9712190|Reactome:R-HSA-9754616 go.json cation channel activity|cation diffusion facilitator activity|non-selective cation channel activity http://purl.obolibrary.org/obo/GO_0005261 GO:0030200 biolink:BiologicalProcess heparan sulfate proteoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. go.json heparan sulfate proteoglycan breakdown|heparan sulfate proteoglycan catabolism|heparan sulfate proteoglycan degradation|heparan sulphate proteoglycan catabolic process|heparan sulphate proteoglycan catabolism|heparin proteoglycan catabolic process http://purl.obolibrary.org/obo/GO_0030200 GO:0030201 biolink:BiologicalProcess heparan sulfate proteoglycan metabolic process The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. go.json heparan sulfate proteoglycan metabolism|heparan sulphate proteoglycan metabolic process|heparan sulphate proteoglycan metabolism|heparin proteoglycan metabolic process http://purl.obolibrary.org/obo/GO_0030201 GO:0005237 biolink:MolecularActivity inhibitory extracellular ligand-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels. go.json inhibitory extracellular ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0005237 RO:0002231 biolink:OntologyClass has start location RO:0002231 go.json http://purl.obolibrary.org/obo/RO_0002231 GO:0005234 biolink:MolecularActivity extracellularly glutamate-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. go.json extracellular-glutamate-gated ion channel activity http://purl.obolibrary.org/obo/GO_0005234 RO:0002232 biolink:OntologyClass has end location RO:0002232 go.json http://purl.obolibrary.org/obo/RO_0002232 GO:0005231 biolink:MolecularActivity excitatory extracellular ligand-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. Reactome:R-HSA-399711|Reactome:R-HSA-399712|Reactome:R-HSA-420980|Reactome:R-HSA-432164|Reactome:R-HSA-438037 go.json http://purl.obolibrary.org/obo/GO_0005231 RO:0002233 biolink:OntologyClass has input RO:0002233 go.json http://purl.obolibrary.org/obo/RO_0002233 RO:0002234 biolink:OntologyClass has output RO:0002234 go.json http://purl.obolibrary.org/obo/RO_0002234 GO:0005232 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005232 GO:0005230 biolink:MolecularActivity extracellular ligand-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. go.json extracellular ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0005230 RO:0002230 biolink:OntologyClass ends with RO:0002230 go.json http://purl.obolibrary.org/obo/RO_0002230 GO:0019878 biolink:BiologicalProcess lysine biosynthetic process via aminoadipic acid The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. go.json lysine anabolism via aminoadipic acid|lysine biosynthesis, aminoadipic acid pathway|lysine biosynthesis, aminoadipic pathway|lysine biosynthetic process, aminoadipic acid pathway|lysine biosynthetic process, aminoadipic pathway|lysine formation via aminoadipic acid|lysine synthesis via aminoadipic acid http://purl.obolibrary.org/obo/GO_0019878 RO:0002224 biolink:OntologyClass starts with RO:0002224 go.json http://purl.obolibrary.org/obo/RO_0002224 GO:0019879 biolink:BiologicalProcess peptidyl-thyronine biosynthetic process from peptidyl-tyrosine The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine. go.json peptidyl-thyronine anabolism from peptidyl-tyrosine|peptidyl-thyronine formation from peptidyl-tyrosine|peptidyl-thyronine synthesis from peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0019879 gocheck_do_not_annotate GO:0019876 biolink:BiologicalProcess nylon catabolic process The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. go.json nylon breakdown|nylon catabolism|nylon degradation http://purl.obolibrary.org/obo/GO_0019876 GO:0019877 biolink:BiologicalProcess diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. go.json diaminopimelate anabolism|diaminopimelate biosynthesis|diaminopimelate formation|diaminopimelate synthesis http://purl.obolibrary.org/obo/GO_0019877 GO:0019874 biolink:MolecularActivity 6-aminohexanoate-cyclic-dimer hydrolase activity Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate. EC:3.5.2.12|KEGG_REACTION:R03448|MetaCyc:3.5.2.12-RXN|RHEA:16225|UM-BBD_reactionID:r1097 go.json 1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity http://purl.obolibrary.org/obo/GO_0019874 GO:0019875 biolink:MolecularActivity 6-aminohexanoate-dimer hydrolase activity Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate. EC:3.5.1.46|MetaCyc:RXN-3962|RHEA:21364|UM-BBD_enzymeID:e0673 go.json 6-aminohexanoic acid oligomer hydrolase activity|N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0019875 GO:0019872 biolink:BiologicalProcess streptomycin biosynthetic process The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. go.json streptomycin anabolism|streptomycin biosynthesis|streptomycin formation|streptomycin synthesis http://purl.obolibrary.org/obo/GO_0019872 GO:0019873 biolink:BiologicalProcess obsolete tellurium sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json tellurium sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0019873 GO:0019870 biolink:MolecularActivity potassium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a potassium channel. go.json http://purl.obolibrary.org/obo/GO_0019870 GO:0019871 biolink:MolecularActivity sodium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a sodium channel. go.json http://purl.obolibrary.org/obo/GO_0019871 GO:0005248 biolink:MolecularActivity voltage-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. Reactome:R-HSA-5576895 go.json voltage gated sodium channel activity|voltage-dependent sodium channel activity|voltage-gated sodium ion channel activity|voltage-sensitive sodium channel http://purl.obolibrary.org/obo/GO_0005248 GO:0005249 biolink:MolecularActivity voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. Reactome:R-HSA-1296127|Reactome:R-HSA-9659554|Reactome:R-HSA-9667761 go.json voltage gated potassium channel activity|voltage-dependent potassium channel activity|voltage-gated potassium ion channel activity|voltage-sensitive potassium channel http://purl.obolibrary.org/obo/GO_0005249 GO:0005246 biolink:MolecularActivity calcium channel regulator activity Modulates the activity of a calcium channel. go.json http://purl.obolibrary.org/obo/GO_0005246 GO:0005247 biolink:MolecularActivity voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. Reactome:R-HSA-2744228 go.json voltage gated chloride channel activity|voltage-dependent chloride channel activity http://purl.obolibrary.org/obo/GO_0005247 RO:0002220 biolink:OntologyClass adjacent to RO:0002220 go.json http://purl.obolibrary.org/obo/RO_0002220 GO:0005244 biolink:MolecularActivity voltage-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage gated ion channel activity|voltage-dependent ion channel activity|voltage-gated ion channel activity http://purl.obolibrary.org/obo/GO_0005244 GO:0005245 biolink:MolecularActivity voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. Reactome:R-HSA-265645|Reactome:R-HSA-5577213|Reactome:R-HSA-9701055|Reactome:R-HSA-9701141 go.json depolarization-activated calcium channel|depolarization-activated voltage gated calcium channel activity|depolarization-activated voltage-gated calcium channel|depolarization-activated voltage-gated calcium channel activity|dihydropyridine-sensitive calcium channel activity|voltage gated calcium channel activity|voltage-dependent calcium channel activity|voltage-gated calcium ion channel activity|voltage-sensitive calcium channel http://purl.obolibrary.org/obo/GO_0005245 GO:0005242 biolink:MolecularActivity inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. Reactome:R-HSA-1296045|Reactome:R-HSA-1296046|Reactome:R-HSA-1369017|Reactome:R-HSA-5678261|Reactome:R-HSA-5678418|Reactome:R-HSA-9729870|Reactome:R-HSA-9730521|Reactome:R-HSA-9731072 go.json Kir channel activity http://purl.obolibrary.org/obo/GO_0005242 GO:0005243 biolink:MolecularActivity gap junction channel activity A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. Reactome:R-HSA-190681|Reactome:R-HSA-375330|Reactome:R-HSA-375339|Reactome:R-HSA-375340|Reactome:R-HSA-375342 go.json connexin|innexin|innexin channel activity|intercellular channel http://purl.obolibrary.org/obo/GO_0005243 GO:0005240 biolink:MolecularActivity obsolete glycine receptor-associated protein OBSOLETE. (Was not defined before being made obsolete). go.json glycine receptor-associated protein True http://purl.obolibrary.org/obo/GO_0005240 GO:0005241 biolink:MolecularActivity obsolete inward rectifier channel OBSOLETE. (Was not defined before being made obsolete). go.json inward rectifier channel True http://purl.obolibrary.org/obo/GO_0005241 RO:0002213 biolink:OntologyClass positively regulates RO:0002213 go.json http://purl.obolibrary.org/obo/RO_0002213 GO:0019889 biolink:BiologicalProcess pteridine metabolic process The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. go.json pteridine metabolism http://purl.obolibrary.org/obo/GO_0019889 RO:0002215 biolink:OntologyClass capable of RO:0002215 go.json http://purl.obolibrary.org/obo/RO_0002215 GO:0019887 biolink:MolecularActivity protein kinase regulator activity Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. go.json http://purl.obolibrary.org/obo/GO_0019887 GO:0019888 biolink:MolecularActivity protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase. Reactome:R-HSA-180038 go.json calcineurin regulator activity|calcineurin, intrinsic regulator activity|protein phosphatase 2 regulator activity|protein phosphatase 2, intrinsic regulator activity|protein phosphatase 3 regulator activity|protein phosphatase 3, intrinsic regulator activity|protein phosphatase type 1 regulator activity|protein phosphatase type 1, intrinsic regulator activity|protein phosphatase type 2A regulator activity|protein phosphatase type 2A, intrinsic regulator activity|protein phosphatase type 2B regulator activity|protein phosphatase type 2B, intrinsic regulator activity|protein phosphatase type 4 regulator activity|protein phosphatase type 4, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0019888 RO:0002216 biolink:OntologyClass capable of part of RO:0002216 go.json http://purl.obolibrary.org/obo/RO_0002216 GO:0019885 biolink:BiologicalProcess antigen processing and presentation of endogenous peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. go.json antigen presentation, endogenous peptide antigen|antigen processing, endogenous antigen via MHC class I|antigen processing, endogenous antigen via major histocompatibility complex class I|endogenous peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_0019885 GO:0019886 biolink:BiologicalProcess antigen processing and presentation of exogenous peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. go.json antigen presentation, exogenous antigen via MHC class II|antigen presentation, exogenous peptide antigen|antigen processing, exogenous antigen via major histocompatibility complex class II|exogenous peptide antigen processing and presentation via MHC class II http://purl.obolibrary.org/obo/GO_0019886 GO:0019883 biolink:BiologicalProcess antigen processing and presentation of endogenous antigen The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. go.json antigen presentation, endogenous antigen http://purl.obolibrary.org/obo/GO_0019883 GO:0019884 biolink:BiologicalProcess antigen processing and presentation of exogenous antigen The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex. go.json antigen presentation, exogenous antigen http://purl.obolibrary.org/obo/GO_0019884 GO:0019881 biolink:BiologicalProcess obsolete streptomycin susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json streptomycin susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0019881 GO:0019882 biolink:BiologicalProcess antigen processing and presentation The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Wikipedia:Antigen_presentation go.json antigen presentation|antigen processing http://purl.obolibrary.org/obo/GO_0019882 GO:0019880 biolink:BiologicalProcess obsolete bacteriocin susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json bacteriocin susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0019880 GO:0044820 biolink:BiologicalProcess mitotic telomere tethering at nuclear periphery The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0044820 RO:0002211 biolink:OntologyClass regulates RO:0002211 go.json http://purl.obolibrary.org/obo/RO_0002211 RO:0002212 biolink:OntologyClass negatively regulates RO:0002212 go.json http://purl.obolibrary.org/obo/RO_0002212 GO:0044827 biolink:BiologicalProcess modulation by host of viral genome replication A process in which a host organism modulates the frequency, rate or extent of viral genome replication. go.json regulation by host of viral genome reproduction http://purl.obolibrary.org/obo/GO_0044827 GO:0044828 biolink:BiologicalProcess negative regulation by host of viral genome replication A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication. go.json http://purl.obolibrary.org/obo/GO_0044828 GO:0044825 biolink:MolecularActivity obsolete retroviral strand transfer activity OBSOLETE. Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction. go.json strand transfer reaction True http://purl.obolibrary.org/obo/GO_0044825 GO:0044826 biolink:BiologicalProcess viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses. go.json viral genome integration http://purl.obolibrary.org/obo/GO_0044826 GO:0044823 biolink:MolecularActivity retroviral integrase activity Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism. go.json http://purl.obolibrary.org/obo/GO_0044823 GO:0044824 biolink:MolecularActivity retroviral 3' processing activity The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls. go.json 3' processing reaction|3'-processing activity http://purl.obolibrary.org/obo/GO_0044824 GO:0044821 biolink:BiologicalProcess meiotic telomere tethering at nuclear periphery The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0044821 GO:0044822 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044822 GO:0044829 biolink:BiologicalProcess positive regulation by host of viral genome replication A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication. go.json http://purl.obolibrary.org/obo/GO_0044829 GO:0044830 biolink:BiologicalProcess modulation by host of viral RNA genome replication A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication. go.json regulation by host of viral RNA genome replication http://purl.obolibrary.org/obo/GO_0044830 GO:0044831 biolink:BiologicalProcess modulation by virus of host cytokine production Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism. go.json http://purl.obolibrary.org/obo/GO_0044831 GO:0044838 biolink:BiologicalProcess cell quiescence A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed. go.json G0 phase|cell cycle quiescence|cellular quiescence|quiescence http://purl.obolibrary.org/obo/GO_0044838 gocheck_do_not_annotate GO:0044839 biolink:BiologicalProcess cell cycle G2/M phase transition The cell cycle process by which a cell in G2 phase commits to M phase. go.json http://purl.obolibrary.org/obo/GO_0044839 GO:0044836 biolink:BiologicalProcess D-xylose fermentation The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP. go.json http://purl.obolibrary.org/obo/GO_0044836 GO:0044837 biolink:BiologicalProcess actomyosin contractile ring organization A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring. go.json cytokinesis, actomyosin contractile ring organization http://purl.obolibrary.org/obo/GO_0044837 GO:0044834 biolink:CellularComponent retroviral intasome A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome. go.json http://purl.obolibrary.org/obo/GO_0044834 GO:0044835 biolink:BiologicalProcess hydrogen generation via nitrogenase The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria. go.json http://purl.obolibrary.org/obo/GO_0044835 GO:0044832 biolink:BiologicalProcess induction by virus of host cytokine production The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism. go.json positive regulation by virus of host cytokine production http://purl.obolibrary.org/obo/GO_0044832 GO:0044833 biolink:BiologicalProcess modulation by virus of host protein transport Any viral process that modulates the frequency, rate or extent of protein transport in its host organism. go.json http://purl.obolibrary.org/obo/GO_0044833 GO:0044841 biolink:CellularComponent gut granule membrane The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. go.json http://purl.obolibrary.org/obo/GO_0044841 GO:0044842 biolink:CellularComponent gut granule lumen The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. go.json http://purl.obolibrary.org/obo/GO_0044842 GO:0044840 biolink:CellularComponent gut granule A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage. go.json http://purl.obolibrary.org/obo/GO_0044840 GO:0044849 biolink:BiologicalProcess estrous cycle A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. Wikipedia:Estrous_cycle go.json http://purl.obolibrary.org/obo/GO_0044849 GO:0044847 biolink:BiologicalProcess iron acquisition from host The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell. go.json acquisition by organism of nutrients from host via siderophores|acquisition by symbiont of nutrients from host via siderophores|heme acquisition|iron acquisition|iron acquisition by symbiont from host|iron acquisition by symbiont from host heme http://purl.obolibrary.org/obo/GO_0044847 GO:0044848 biolink:BiologicalProcess biological phase A distinct period or stage in a biological process or cycle. go.json http://purl.obolibrary.org/obo/GO_0044848 gocheck_do_not_manually_annotate GO:0044845 biolink:BiologicalProcess chain elongation of O-linked mannose residue Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules. go.json http://purl.obolibrary.org/obo/GO_0044845 GO:0044846 biolink:BiologicalProcess negative regulation by symbiont of indole acetic acid levels in host Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by symbiont of IAA levels in host|negative regulation by symbiont of auxin levels in host http://purl.obolibrary.org/obo/GO_0044846 GO:0044843 biolink:BiologicalProcess cell cycle G1/S phase transition The cell cycle process by which a cell in G1 phase commits to S phase. go.json http://purl.obolibrary.org/obo/GO_0044843 GO:0044844 biolink:BiologicalProcess meiotic interphase II The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge. go.json http://purl.obolibrary.org/obo/GO_0044844 gocheck_do_not_annotate GO:0044852 biolink:BiologicalProcess obsolete nonrepetitive DNA condensation OBSOLETE. The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells. go.json nonrepetitive DNA packaging True http://purl.obolibrary.org/obo/GO_0044852 GO:0044853 biolink:CellularComponent plasma membrane raft A membrane raft that is part of the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0044853 GO:0044850 biolink:BiologicalProcess menstrual cycle A type of ovulation cycle where the endometrium is shed if pregnancy does not occur. Wikipedia:Menstrual_cycle go.json http://purl.obolibrary.org/obo/GO_0044850 GO:0044851 biolink:BiologicalProcess hair cycle phase The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. go.json http://purl.obolibrary.org/obo/GO_0044851 gocheck_do_not_annotate GO:0044858 biolink:BiologicalProcess plasma membrane raft polarization The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. go.json plasma membrane polarization http://purl.obolibrary.org/obo/GO_0044858 GO:0044859 biolink:BiologicalProcess protein insertion into plasma membrane raft The process in which a protein is incorporated into a plasma membrane raft. go.json http://purl.obolibrary.org/obo/GO_0044859 GO:0044856 biolink:BiologicalProcess plasma membrane raft localization Any process in which plasma membrane rafts are transported to, or maintained in, a specific location. go.json http://purl.obolibrary.org/obo/GO_0044856 GO:0044857 biolink:BiologicalProcess plasma membrane raft organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts. go.json http://purl.obolibrary.org/obo/GO_0044857 GO:0044854 biolink:BiologicalProcess plasma membrane raft assembly The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft. go.json http://purl.obolibrary.org/obo/GO_0044854 GO:0044855 biolink:BiologicalProcess plasma membrane raft distribution The process that establishes the spatial arrangement of membrane rafts within a plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0044855 GO:0044863 biolink:BiologicalProcess modulation by virus of host cell division Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells. go.json regulation by virus of host cell division http://purl.obolibrary.org/obo/GO_0044863 GO:0044864 biolink:BiologicalProcess positive regulation by virus of host cell division Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division. go.json http://purl.obolibrary.org/obo/GO_0044864 GO:0044861 biolink:BiologicalProcess protein transport into plasma membrane raft The directed movement of a protein into a plasma membrane raft. go.json http://purl.obolibrary.org/obo/GO_0044861 GO:0044862 biolink:BiologicalProcess protein transport out of plasma membrane raft The directed movement of a protein out of a plasma membrane raft. go.json http://purl.obolibrary.org/obo/GO_0044862 GO:0044860 biolink:BiologicalProcess protein localization to plasma membrane raft A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft. go.json http://purl.obolibrary.org/obo/GO_0044860 GO:0030291 biolink:MolecularActivity protein serine/threonine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. go.json http://purl.obolibrary.org/obo/GO_0030291 GO:0030292 biolink:MolecularActivity protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a protein tyrosine kinase. go.json http://purl.obolibrary.org/obo/GO_0030292 GO:0044869 biolink:BiologicalProcess negative regulation by host of viral exo-alpha-sialidase activity The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. go.json http://purl.obolibrary.org/obo/GO_0044869 GO:0030290 biolink:MolecularActivity sphingolipid activator protein activity Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase. Reactome:R-HSA-1605717|Reactome:R-HSA-9840470 go.json saposin http://purl.obolibrary.org/obo/GO_0030290 GO:0044867 biolink:BiologicalProcess modulation by host of viral catalytic activity The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected. go.json http://purl.obolibrary.org/obo/GO_0044867 GO:0044868 biolink:BiologicalProcess modulation by host of viral molecular function A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected. go.json http://purl.obolibrary.org/obo/GO_0044868 GO:0044865 biolink:BiologicalProcess negative regulation by virus of host cell division Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division. go.json inhibition by virus of host cell division http://purl.obolibrary.org/obo/GO_0044865 GO:0044866 biolink:BiologicalProcess modulation by host of viral exo-alpha-sialidase activity The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. go.json http://purl.obolibrary.org/obo/GO_0044866 GO:0030299 biolink:BiologicalProcess intestinal cholesterol absorption Uptake of cholesterol into the blood by absorption from the small intestine. go.json http://purl.obolibrary.org/obo/GO_0030299 GO:0030297 biolink:MolecularActivity transmembrane receptor protein tyrosine kinase activator activity Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase. go.json http://purl.obolibrary.org/obo/GO_0030297 GO:0030298 biolink:MolecularActivity receptor signaling protein tyrosine kinase activator activity Binds to and increases the activity of a receptor signaling protein tyrosine kinase. go.json receptor signalling protein tyrosine kinase activator activity http://purl.obolibrary.org/obo/GO_0030298 GO:0030295 biolink:MolecularActivity protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. go.json http://purl.obolibrary.org/obo/GO_0030295 GO:0030296 biolink:MolecularActivity protein tyrosine kinase activator activity Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. go.json http://purl.obolibrary.org/obo/GO_0030296 GO:0030293 biolink:MolecularActivity transmembrane receptor protein tyrosine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase. go.json http://purl.obolibrary.org/obo/GO_0030293 GO:0030294 biolink:MolecularActivity receptor signaling protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase. go.json receptor signalling protein tyrosine kinase inhibitor activity http://purl.obolibrary.org/obo/GO_0030294 GO:0044874 biolink:BiologicalProcess lipoprotein localization to outer membrane A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. go.json http://purl.obolibrary.org/obo/GO_0044874 GO:0044875 biolink:MolecularActivity gamma-glutamyl hercynylcysteine sulfoxide synthase activity Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O. EC:1.14.99.50|RHEA:42672 go.json gamma-glutamyl hercynylcysteine S-oxide synthase|gamma-glutamyl hercynylcysteine sulfoxide synthase http://purl.obolibrary.org/obo/GO_0044875 GO:0044872 biolink:BiologicalProcess lipoprotein localization Any process in which a lipoprotein is transported to, or maintained in, a specific location. go.json http://purl.obolibrary.org/obo/GO_0044872 GO:0044873 biolink:BiologicalProcess lipoprotein localization to membrane A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. go.json http://purl.obolibrary.org/obo/GO_0044873 GO:0044870 biolink:BiologicalProcess modulation by host of viral glycoprotein metabolic process A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process. go.json http://purl.obolibrary.org/obo/GO_0044870 GO:0044871 biolink:BiologicalProcess negative regulation by host of viral glycoprotein metabolic process A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process. go.json http://purl.obolibrary.org/obo/GO_0044871 GO:0030280 biolink:MolecularActivity structural constituent of skin epidermis The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. go.json structural constituent of epidermis http://purl.obolibrary.org/obo/GO_0030280 GO:0030281 biolink:MolecularActivity structural constituent of cutaneous appendage The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers. go.json http://purl.obolibrary.org/obo/GO_0030281 GO:0044878 biolink:BiologicalProcess mitotic cytokinesis checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed. go.json cytokinesis after mitosis checkpoint|defective cytokinesis checkpoint|mitotic cytokinesis checkpoint|signal transduction involved in mitotic cytokinesis checkpoint|signaling pathway involved in mitotic cytokinesis checkpoint|signalling cascade involved in mitotic cytokinesis checkpoint|signalling pathway involved in mitotic cytokinesis checkpoint http://purl.obolibrary.org/obo/GO_0044878 GO:0044879 biolink:BiologicalProcess mitotic morphogenesis checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth. go.json morphogenesis checkpoint|septin checkpoint|signal transduction involved in morphogenesis checkpoint|signal transduction involved in septin checkpoint|signaling cascade involved in morphogenesis checkpoint|signaling cascade involved in septin checkpoint|signaling pathway involved in morphogenesis checkpoint|signaling pathway involved in septin checkpoint|signalling cascade involved in morphogenesis checkpoint|signalling cascade involved in septin checkpoint|signalling pathway involved in morphogenesis checkpoint|signalling pathway involved in septin checkpoint http://purl.obolibrary.org/obo/GO_0044879 GO:0044876 biolink:MolecularActivity hercynylselenocysteine synthase Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 = 2 H2O + 2 hercynylselenocysteine. MetaCyc:RXN-15803|RHEA:42680 go.json http://purl.obolibrary.org/obo/GO_0044876 GO:0044877 biolink:MolecularActivity protein-containing complex binding Binding to a macromolecular complex. go.json macromolecular complex binding|protein complex binding http://purl.obolibrary.org/obo/GO_0044877 goslim_chembl GO:0030288 biolink:CellularComponent outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. Wikipedia:Periplasmic_space go.json outer membrane bounded periplasmic space|outer membrane-enclosed periplasmic space http://purl.obolibrary.org/obo/GO_0030288 GO:0030289 biolink:CellularComponent protein phosphatase 4 complex A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits. go.json http://purl.obolibrary.org/obo/GO_0030289 GO:0030286 biolink:CellularComponent dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. go.json http://purl.obolibrary.org/obo/GO_0030286 GO:0030287 biolink:CellularComponent cell wall-bounded periplasmic space The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria. go.json IWZ|cell wall bounded periplasmic space|cell wall-enclosed periplasmic space|inner wall zone http://purl.obolibrary.org/obo/GO_0030287 GO:0030284 biolink:MolecularActivity nuclear estrogen receptor activity Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. go.json estrogen receptor activity http://purl.obolibrary.org/obo/GO_0030284 GO:0030285 biolink:CellularComponent obsolete integral component of synaptic vesicle membrane OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to synaptic vesicle membrane True http://purl.obolibrary.org/obo/GO_0030285 GO:0030282 biolink:BiologicalProcess bone mineralization The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. go.json bone calcification http://purl.obolibrary.org/obo/GO_0030282 GO:0030283 biolink:MolecularActivity testosterone dehydrogenase [NAD(P)] activity Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. EC:1.1.1.51|MetaCyc:1.1.1.51-RXN|Reactome:R-HSA-193064 go.json 17beta-hydroxy steroid dehydrogenase|3(or 17)beta-hydroxysteroid dehydrogenase activity|3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase|3beta-hydroxy steroid dehydrogenase|3beta-hydroxysteroid dehydrogenase|beta-hydroxy steroid dehydrogenase http://purl.obolibrary.org/obo/GO_0030283 GO:0030279 biolink:BiologicalProcess negative regulation of ossification Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. go.json down regulation of ossification|down-regulation of ossification|downregulation of ossification|inhibition of ossification|negative regulation of bone biosynthesis|negative regulation of bone formation http://purl.obolibrary.org/obo/GO_0030279 GO:0030270 biolink:MolecularActivity formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran. EC:2.3.1.101|KEGG_REACTION:R03390|MetaCyc:2.3.1.101-RXN|RHEA:18061|UM-BBD_reactionID:r0346 go.json FTR|N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity|formylmethanofuran-tetrahydromethanopterin formyltransferase activity|formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity|formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity|formylmethanofuran:tetrahydromethanopterin formyltransferase activity http://purl.obolibrary.org/obo/GO_0030270 GO:0030277 biolink:BiologicalProcess maintenance of gastrointestinal epithelium Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. go.json http://purl.obolibrary.org/obo/GO_0030277 GO:0030278 biolink:BiologicalProcess regulation of ossification Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. go.json regulation of bone biosynthesis|regulation of bone formation http://purl.obolibrary.org/obo/GO_0030278 GO:0030275 biolink:MolecularActivity LRR domain binding Binding to a LRR domain (leucine rich repeats) of a protein. go.json http://purl.obolibrary.org/obo/GO_0030275 GO:0030276 biolink:MolecularActivity clathrin binding Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. go.json http://purl.obolibrary.org/obo/GO_0030276 GO:0030273 biolink:MolecularActivity melanin-concentrating hormone receptor activity Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity. go.json MCH receptor http://purl.obolibrary.org/obo/GO_0030273 GO:0030274 biolink:MolecularActivity LIM domain binding Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. go.json http://purl.obolibrary.org/obo/GO_0030274 GO:0030271 biolink:MolecularActivity obsolete chymase activity OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa. go.json SK protease activity|chymase activity|mast cell protease I activity|mast cell serine proteinase|skeletal muscle (SK) protease activity|skeletal muscle protease|skin chymotryptic proteinase True http://purl.obolibrary.org/obo/GO_0030271 GO:0030272 biolink:MolecularActivity 5-formyltetrahydrofolate cyclo-ligase activity Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate. EC:6.3.3.2|KEGG_REACTION:R02301|MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN|RHEA:10488|Reactome:R-HSA-6801342 go.json 5,10-methenyltetrahydrofolate synthetase activity|5-Formyltetrahydrofolate cyclodehydrase activity|5-formyltetrahydrofolate cyclo-ligase (ADP-forming)|5-formyltetrahydrofolate cyclodehydrase|formyltetrahydrofolic cyclodehydrase activity|methenyl-THF synthetase activity http://purl.obolibrary.org/obo/GO_0030272 GO:0030268 biolink:MolecularActivity methylenetetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420. EC:1.5.98.1|KEGG_REACTION:R04456|MetaCyc:1.5.99.9-RXN|RHEA:16721|UM-BBD_reactionID:r0348 go.json 5,10-methylenetetrahydromethanopterin dehydrogenase activity|5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0030268 GO:0030269 biolink:MolecularActivity tetrahydromethanopterin S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM. EC:2.1.1.86|KEGG_REACTION:R04347|MetaCyc:2.1.1.86-RXN|RHEA:53492|UM-BBD_reactionID:r0355 go.json 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity|N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity|N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity|tetrahydromethanopterin methyltransferase activity http://purl.obolibrary.org/obo/GO_0030269 GO:0030266 biolink:MolecularActivity quinate 3-dehydrogenase (NAD+) activity Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+. EC:1.1.1.24|EC:1.1.1.282|KEGG_REACTION:R01872|MetaCyc:QUINATE-5-DEHYDROGENASE-RXN|RHEA:22364 go.json quinate:NAD 3-oxidoreductase activity|quinate:NAD 5-oxidoreductase activity|quinate:NAD(+) 3-oxidoreductase activity|quinate:NAD(+) 5-oxidoreductase activity|quinic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0030266 GO:0030267 biolink:MolecularActivity glyoxylate reductase (NADP+) activity Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. EC:1.1.1.79|MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN|RHEA:10992|Reactome:R-HSA-389826|Wikipedia:Glyoxylate_reductase_(NADP+) go.json NADPH-glyoxylate reductase activity|glycolate:NADP+ oxidoreductase activity|glyoxylate reductase (NADP+) http://purl.obolibrary.org/obo/GO_0030267 GO:0030264 biolink:BiologicalProcess nuclear fragmentation involved in apoptotic nuclear change The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. go.json apoptotic nuclear fragmentation|nuclear fragmentation during apoptosis|nucleus fragmentation http://purl.obolibrary.org/obo/GO_0030264 GO:0030265 biolink:BiologicalProcess phospholipase C-activating rhodopsin mediated signaling pathway A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by a rhodopsin molecule being activated by a photon, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json PLC-activating rhodopsin mediated signaling pathway|phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway|rhodopsin mediated G protein signaling, coupled to IP3 second messenger|rhodopsin mediated G protein signalling, coupled to IP3 second messenger|rhodopsin mediated G-protein signaling, coupled to IP3 second messenger|rhodopsin mediated G-protein signalling, coupled to IP3 second messenger http://purl.obolibrary.org/obo/GO_0030265 GO:0030262 biolink:BiologicalProcess apoptotic nuclear changes Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. go.json apoptotic nuclear change http://purl.obolibrary.org/obo/GO_0030262 GO:0030263 biolink:BiologicalProcess apoptotic chromosome condensation The compaction of chromatin during apoptosis. Wikipedia:Pyknosis go.json pyknosis http://purl.obolibrary.org/obo/GO_0030263 GO:0030260 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030260 GO:0030261 biolink:BiologicalProcess chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. go.json DNA condensation|eukaryotic chromosome condensation|nuclear chromosome condensation http://purl.obolibrary.org/obo/GO_0030261 GO:0044805 biolink:BiologicalProcess obsolete late nucleophagy OBSOLETE. A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. go.json True http://purl.obolibrary.org/obo/GO_0044805 GO:0044806 biolink:BiologicalProcess G-quadruplex DNA unwinding The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'. go.json http://purl.obolibrary.org/obo/GO_0044806 GO:0044803 biolink:BiologicalProcess obsolete multi-organism membrane organization OBSOLETE. A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. go.json True http://purl.obolibrary.org/obo/GO_0044803 GO:0044804 biolink:BiologicalProcess nucleophagy A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. go.json autophagy of nucleus|late nucleophagy|nucleus degradation http://purl.obolibrary.org/obo/GO_0044804 GO:0044801 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044801 GO:0044802 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044802 GO:0044800 biolink:BiologicalProcess obsolete multi-organism membrane fusion OBSOLETE. The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism. go.json True http://purl.obolibrary.org/obo/GO_0044800 GO:0044809 biolink:BiologicalProcess chemokine (C-C motif) ligand 17 production The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL17 production|TARC production|thymus and activation regulated chemokine production http://purl.obolibrary.org/obo/GO_0044809 gocheck_do_not_annotate GO:0044807 biolink:BiologicalProcess macrophage migration inhibitory factor production The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json MIF production http://purl.obolibrary.org/obo/GO_0044807 gocheck_do_not_annotate GO:0044808 biolink:BiologicalProcess oncostatin M production The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json OSM production http://purl.obolibrary.org/obo/GO_0044808 gocheck_do_not_annotate GO:0044816 biolink:CellularComponent Nsk1-Dlc1 complex A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation. go.json http://purl.obolibrary.org/obo/GO_0044816 GO:0044817 biolink:BiologicalProcess hydrogen generation via biophotolysis The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae. go.json hydrogen biosynthesis via biophotolysis http://purl.obolibrary.org/obo/GO_0044817 GO:0044814 biolink:BiologicalProcess glycolytic fermentation via PFL pathway The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli. go.json http://purl.obolibrary.org/obo/GO_0044814 GO:0044815 biolink:CellularComponent obsolete DNA packaging complex OBSOLETE. A protein complex that plays a role in the process of DNA packaging. go.json True http://purl.obolibrary.org/obo/GO_0044815 GO:0044812 biolink:BiologicalProcess fermentative hydrogen production The fermentation of organic substances with a net release of hydrogen. Wikipedia:Fermentative_hydrogen_production go.json carbohydrate fermentation http://purl.obolibrary.org/obo/GO_0044812 GO:0044813 biolink:BiologicalProcess glycolytic fermentation via PFOR pathway The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species. MetaCyc:CENTFERM-PWY go.json http://purl.obolibrary.org/obo/GO_0044813 GO:0044810 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044810 GO:0044811 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044811 GO:0044818 biolink:BiologicalProcess mitotic G2/M transition checkpoint A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0044818 GO:0044819 biolink:BiologicalProcess mitotic G1/S transition checkpoint signaling A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle. go.json mitotic G1/S transition checkpoint http://purl.obolibrary.org/obo/GO_0044819 GO:0005219 biolink:MolecularActivity ryanodine-sensitive calcium-release channel activity Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine. Reactome:R-HSA-2855020 go.json caffeine-sensitive calcium-release channel|ryanodine receptor http://purl.obolibrary.org/obo/GO_0005219 GO:0005217 biolink:MolecularActivity intracellular ligand-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. go.json intracellular ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0005217 GO:0005218 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005218 GO:0005215 biolink:MolecularActivity transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. go.json carrier http://purl.obolibrary.org/obo/GO_0005215 gocheck_do_not_annotate|goslim_agr|goslim_candida|goslim_chembl|goslim_flybase_ribbon|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant|prokaryote_subset GO:0005216 biolink:MolecularActivity monoatomic ion channel activity Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). go.json ion channel activity http://purl.obolibrary.org/obo/GO_0005216 GO:0005213 biolink:MolecularActivity structural constituent of egg chorion The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster. go.json structural constituent of chorion|structural protein of chorion http://purl.obolibrary.org/obo/GO_0005213 GO:0005214 biolink:MolecularActivity structural constituent of chitin-based cuticle The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0005214 GO:0005211 biolink:MolecularActivity obsolete plasma glycoprotein OBSOLETE. (Was not defined before being made obsolete). go.json plasma glycoprotein True http://purl.obolibrary.org/obo/GO_0005211 GO:0005212 biolink:MolecularActivity structural constituent of eye lens The action of a molecule that contributes to the structural integrity of the lens of an eye. go.json http://purl.obolibrary.org/obo/GO_0005212 GO:0019858 biolink:BiologicalProcess cytosine metabolic process The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. go.json cytosine metabolism http://purl.obolibrary.org/obo/GO_0019858 GO:0019859 biolink:BiologicalProcess thymine metabolic process The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. go.json thymine metabolism http://purl.obolibrary.org/obo/GO_0019859 GO:0019856 biolink:BiologicalProcess pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. go.json pyrimidine base anabolism|pyrimidine base biosynthesis|pyrimidine base biosynthetic process|pyrimidine base formation|pyrimidine base synthesis http://purl.obolibrary.org/obo/GO_0019856 GO:0019857 biolink:BiologicalProcess 5-methylcytosine metabolic process The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA. go.json 5-methylcytosine metabolism http://purl.obolibrary.org/obo/GO_0019857 GO:0019854 biolink:BiologicalProcess L-ascorbic acid catabolic process The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. MetaCyc:PWY0-301 go.json L-ascorbic acid breakdown|L-ascorbic acid catabolism|L-ascorbic acid degradation|ascorbate catabolic process|ascorbate catabolism|vitamin C catabolic process|vitamin C catabolism http://purl.obolibrary.org/obo/GO_0019854 GO:0019855 biolink:MolecularActivity calcium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a calcium channel. go.json http://purl.obolibrary.org/obo/GO_0019855 GO:0019852 biolink:BiologicalProcess L-ascorbic acid metabolic process The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. go.json L-ascorbic acid metabolism|ascorbate metabolic process|ascorbate metabolism|vitamin C metabolic process|vitamin C metabolism http://purl.obolibrary.org/obo/GO_0019852 GO:0019853 biolink:BiologicalProcess L-ascorbic acid biosynthetic process The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. MetaCyc:PWY-882 go.json L-ascorbic acid anabolism|L-ascorbic acid biosynthesis|L-ascorbic acid formation|L-ascorbic acid synthesis|ascorbate biosynthesis|ascorbate biosynthetic process|vitamin C biosynthesis|vitamin C biosynthetic process http://purl.obolibrary.org/obo/GO_0019853 GO:0019850 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019850 GO:0019851 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019851 GO:0005228 biolink:MolecularActivity intracellular sodium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification. go.json intracellular sodium activated potassium channel activity http://purl.obolibrary.org/obo/GO_0005228 GO:0005229 biolink:MolecularActivity intracellular calcium activated chloride channel activity Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Reactome:R-HSA-2684901|Reactome:R-HSA-2744242|Reactome:R-HSA-2744361|Reactome:R-HSA-9659568 go.json http://purl.obolibrary.org/obo/GO_0005229 GO:0005226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005226 GO:0005227 biolink:MolecularActivity calcium-activated cation channel activity Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. Reactome:R-HSA-9717383 go.json calcium activated cation channel activity|intracellular calcium-activated potassium channel|polycystin http://purl.obolibrary.org/obo/GO_0005227 GO:0005224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005224 GO:0005225 biolink:MolecularActivity volume-sensitive anion channel activity Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. Reactome:R-HSA-8941543 go.json volume-regulated channel http://purl.obolibrary.org/obo/GO_0005225 GO:0005222 biolink:MolecularActivity intracellular cAMP-activated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. go.json HCN channel activity|hyperpolarization-activated cyclic nucleotide-gated channel activity|intracellular 3',5' cAMP activated cation channel activity|intracellular 3',5'-cAMP activated cation channel activity|intracellular adenosine 3',5'-cyclophosphate activated cation channel activity|intracellular cAMP activated cation channel activity|intracellular cyclic AMP activated cation channel activity http://purl.obolibrary.org/obo/GO_0005222 GO:0005223 biolink:MolecularActivity intracellular cGMP-activated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. go.json intracellular cGMP activated cation channel activity http://purl.obolibrary.org/obo/GO_0005223 GO:0005220 biolink:MolecularActivity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. go.json IP3 receptor activity|InsP3 receptor|inositol-1,4,5-trisphosphate receptor activity http://purl.obolibrary.org/obo/GO_0005220 GO:0005221 biolink:MolecularActivity intracellular cyclic nucleotide-activated monoatomic cation channel activity Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. Reactome:R-HSA-2514867 go.json intracellular cyclic nucleotide activated cation channel activity|intracellular cyclic nucleotide activated monoatomic cation channel activity http://purl.obolibrary.org/obo/GO_0005221 GO:0019869 biolink:MolecularActivity chloride channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a chloride channel. go.json http://purl.obolibrary.org/obo/GO_0019869 GO:0019867 biolink:CellularComponent outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. go.json http://purl.obolibrary.org/obo/GO_0019867 goslim_metagenomics GO:0019868 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019868 GO:0019865 biolink:MolecularActivity immunoglobulin binding Binding to an immunoglobulin. go.json http://purl.obolibrary.org/obo/GO_0019865 GO:0019866 biolink:CellularComponent organelle inner membrane The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. go.json http://purl.obolibrary.org/obo/GO_0019866 GO:0019863 biolink:MolecularActivity IgE binding Binding to an immunoglobulin of the IgE isotype. go.json http://purl.obolibrary.org/obo/GO_0019863 GO:0019864 biolink:MolecularActivity IgG binding Binding to an immunoglobulin of an IgG isotype. go.json http://purl.obolibrary.org/obo/GO_0019864 goslim_chembl GO:0019861 biolink:CellularComponent obsolete flagellum OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium. Wikipedia:Flagellum go.json flagellum True http://purl.obolibrary.org/obo/GO_0019861 GO:0019862 biolink:MolecularActivity IgA binding Binding to an immunoglobulin of an IgA isotype. go.json http://purl.obolibrary.org/obo/GO_0019862 GO:0019860 biolink:BiologicalProcess uracil metabolic process The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. go.json uracil metabolism http://purl.obolibrary.org/obo/GO_0019860 GO:0019838 biolink:MolecularActivity growth factor binding Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. go.json neurotrophin TRK receptor activity http://purl.obolibrary.org/obo/GO_0019838 goslim_chembl GO:0019839 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019839 GO:0019836 biolink:BiologicalProcess hemolysis by symbiont of host erythrocytes The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json haemolysis in host|hemolysin activity|hemolysis by symbiont of host RBCs|hemolysis by symbiont of host red blood cells|pathogenesis|regulation of cytolysis of host cells by symbiont http://purl.obolibrary.org/obo/GO_0019836 GO:0019837 biolink:BiologicalProcess obsolete herbicide susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json herbicide susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0019837 GO:0019834 biolink:MolecularActivity phospholipase A2 inhibitor activity Binds to and stops, prevents or reduces the activity of phospholipase A2. go.json http://purl.obolibrary.org/obo/GO_0019834 GO:0019835 biolink:BiologicalProcess cytolysis The rupture of cell membranes and the loss of cytoplasm. Wikipedia:Cytolysis go.json autolysin activity|bacteriocin activity|bacteriolytic toxin activity|holin|lysin activity|lysis|necrosis http://purl.obolibrary.org/obo/GO_0019835 goslim_chembl GO:0019832 biolink:BiologicalProcess obsolete mercuric sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json mercuric sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0019832 GO:0019833 biolink:MolecularActivity obsolete ice nucleation activity OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation. go.json ice nucleation activity True http://purl.obolibrary.org/obo/GO_0019833 GO:0019830 biolink:BiologicalProcess obsolete cadmium sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json cadmium sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0019830 GO:0019831 biolink:BiologicalProcess obsolete chromate sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json chromate sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0019831 GO:0005208 biolink:MolecularActivity obsolete amyloid protein OBSOLETE. (Was not defined before being made obsolete). go.json amyloid protein True http://purl.obolibrary.org/obo/GO_0005208 GO:0005209 biolink:MolecularActivity obsolete plasma protein OBSOLETE. (Was not defined before being made obsolete). go.json plasma protein True http://purl.obolibrary.org/obo/GO_0005209 GO:0005206 biolink:MolecularActivity obsolete heparin sulfate proteoglycan OBSOLETE. (Was not defined before being made obsolete). go.json heparin sulfate proteoglycan|heparin sulphate proteoglycan True http://purl.obolibrary.org/obo/GO_0005206 GO:0005207 biolink:MolecularActivity obsolete extracellular matrix glycoprotein OBSOLETE. (Was not defined before being made obsolete). go.json extracellular matrix glycoprotein True http://purl.obolibrary.org/obo/GO_0005207 GO:0005204 biolink:MolecularActivity obsolete chondroitin sulfate proteoglycan OBSOLETE. (Was not defined before being made obsolete). go.json chondroitin sulfate proteoglycan|chondroitin sulphate proteoglycan True http://purl.obolibrary.org/obo/GO_0005204 GO:0005205 biolink:MolecularActivity obsolete chondroitin sulfate/dermatan sulfate proteoglycan OBSOLETE. (Was not defined before being made obsolete). go.json chondroitin sulfate/dermatan sulfate proteoglycan|chondroitin sulphate/dermatan sulphate proteoglycan True http://purl.obolibrary.org/obo/GO_0005205 GO:0005202 biolink:MolecularActivity obsolete collagen OBSOLETE. (Was not defined before being made obsolete). go.json collagen True http://purl.obolibrary.org/obo/GO_0005202 GO:0005203 biolink:MolecularActivity obsolete proteoglycan OBSOLETE. (Was not defined before being made obsolete). go.json proteoglycan True http://purl.obolibrary.org/obo/GO_0005203 GO:0005200 biolink:MolecularActivity structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. go.json http://purl.obolibrary.org/obo/GO_0005200 goslim_drosophila GO:0005201 biolink:MolecularActivity extracellular matrix structural constituent The action of a molecule that contributes to the structural integrity of the extracellular matrix. go.json core extracellular matrix|core matrisome|extracellular matrix glycoprotein http://purl.obolibrary.org/obo/GO_0005201 goslim_drosophila GO:0019849 biolink:MolecularActivity obsolete cytotoxin activity OBSOLETE. Acts as to cause injury to other living cells. go.json cytotoxin activity True http://purl.obolibrary.org/obo/GO_0019849 GO:0019847 biolink:MolecularActivity obsolete neurotoxin activity OBSOLETE. Acts to inhibit neural function in another living organism. go.json neurotoxin activity True http://purl.obolibrary.org/obo/GO_0019847 GO:0019848 biolink:MolecularActivity obsolete conotoxin activity OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species. go.json conotoxin activity True http://purl.obolibrary.org/obo/GO_0019848 GO:0019845 biolink:MolecularActivity obsolete exotoxin activity OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium. go.json exotoxin activity True http://purl.obolibrary.org/obo/GO_0019845 GO:0019846 biolink:MolecularActivity obsolete enterotoxin activity OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms. go.json enterotoxin activity True http://purl.obolibrary.org/obo/GO_0019846 GO:0019843 biolink:MolecularActivity rRNA binding Binding to a ribosomal RNA. go.json base pairing with rRNA http://purl.obolibrary.org/obo/GO_0019843 goslim_chembl|goslim_yeast GO:0019844 biolink:MolecularActivity obsolete endotoxin activity OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell. go.json endotoxin activity True http://purl.obolibrary.org/obo/GO_0019844 GO:0019841 biolink:MolecularActivity retinol binding Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. go.json vitamin A1 alcohol binding|vitamin A1 binding http://purl.obolibrary.org/obo/GO_0019841 GO:0019842 biolink:MolecularActivity vitamin binding Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json http://purl.obolibrary.org/obo/GO_0019842 goslim_metagenomics|goslim_pir GO:0019840 biolink:MolecularActivity isoprenoid binding Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. go.json http://purl.obolibrary.org/obo/GO_0019840 goslim_pir GO:0019818 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019818 GO:0019819 biolink:CellularComponent P1 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms. go.json peroxisome vesicle http://purl.obolibrary.org/obo/GO_0019819 GO:0019816 biolink:CellularComponent obsolete B cell receptor accessory molecule complex OBSOLETE. (Was not defined before being made obsolete). go.json B cell receptor accessory molecule complex True http://purl.obolibrary.org/obo/GO_0019816 GO:0019817 biolink:BiologicalProcess vesicle fusion with peroxisome The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome. go.json http://purl.obolibrary.org/obo/GO_0019817 GO:0019814 biolink:CellularComponent immunoglobulin complex A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json antibody http://purl.obolibrary.org/obo/GO_0019814 goslim_pir GO:0019815 biolink:CellularComponent B cell receptor complex An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json B cell receptor accessory molecule complex|B lymphocyte receptor complex|B-cell receptor complex|B-lymphocyte receptor complex|BCR complex|antibody|immunoglobulin complex, membrane bound http://purl.obolibrary.org/obo/GO_0019815 GO:0019812 biolink:CellularComponent type I site-specific deoxyribonuclease complex A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell. go.json type I restriction enzyme complex http://purl.obolibrary.org/obo/GO_0019812 GO:0019813 biolink:CellularComponent type III site-specific deoxyribonuclease complex A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. go.json type III restriction enzyme complex http://purl.obolibrary.org/obo/GO_0019813 GO:0019810 biolink:MolecularActivity putrescine binding Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. go.json http://purl.obolibrary.org/obo/GO_0019810 GO:0019811 biolink:MolecularActivity cocaine binding Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis. go.json http://purl.obolibrary.org/obo/GO_0019811 GO:0019829 biolink:MolecularActivity ATPase-coupled monoatomic cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). Reactome:R-HSA-5251989|Reactome:R-HSA-5692480 go.json ATP-dependent cation transmembrane transporter activity|ATPase-coupled cation transmembrane transporter activity|cation ABC transporter|cation-transporting ATPase activity|plasma membrane cation-transporting ATPase http://purl.obolibrary.org/obo/GO_0019829 GO:0019827 biolink:BiologicalProcess stem cell population maintenance The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. go.json maintenance of pluripotency http://purl.obolibrary.org/obo/GO_0019827 GO:0019828 biolink:MolecularActivity aspartic-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases. go.json aspartic protease inhibitor activity http://purl.obolibrary.org/obo/GO_0019828 GO:0019825 biolink:MolecularActivity oxygen binding Binding to oxygen (O2). go.json cytochrome P450|cytochrome P450 activity http://purl.obolibrary.org/obo/GO_0019825 goslim_pir|goslim_plant GO:0019826 biolink:MolecularActivity oxygen sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). go.json http://purl.obolibrary.org/obo/GO_0019826 GO:0019823 biolink:CellularComponent P5 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. go.json peroxisome vesicle http://purl.obolibrary.org/obo/GO_0019823 GO:0019824 biolink:CellularComponent P6 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes. go.json peroxisome vesicle http://purl.obolibrary.org/obo/GO_0019824 GO:0019821 biolink:CellularComponent P3 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content. go.json peroxisome vesicle http://purl.obolibrary.org/obo/GO_0019821 GO:0019822 biolink:CellularComponent P4 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. go.json peroxisome vesicle http://purl.obolibrary.org/obo/GO_0019822 GO:0019820 biolink:CellularComponent P2 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed. go.json peroxisome vesicle http://purl.obolibrary.org/obo/GO_0019820 GO:0019809 biolink:MolecularActivity spermidine binding Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. go.json http://purl.obolibrary.org/obo/GO_0019809 GO:0019807 biolink:MolecularActivity aspartoacylase activity Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. EC:3.5.1.15|MetaCyc:ASPARTOACYLASE-RXN|RHEA:10872|Reactome:R-HSA-5691507 go.json N-acetylaspartate amidohydrolase activity|N-acyl-L-aspartate amidohydrolase activity|acetyl-aspartic deaminase activity|acylase II|aminoacylase II activity http://purl.obolibrary.org/obo/GO_0019807 GO:0019808 biolink:MolecularActivity polyamine binding Binding to a polyamine, an organic compound containing two or more amino groups. go.json http://purl.obolibrary.org/obo/GO_0019808 GO:0019805 biolink:BiologicalProcess quinolinate biosynthetic process The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. go.json quinolinate anabolism|quinolinate biosynthesis|quinolinate formation|quinolinate synthesis http://purl.obolibrary.org/obo/GO_0019805 GO:0019806 biolink:MolecularActivity bromide peroxidase activity Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide. EC:1.11.1.18 go.json bromoperoxidase activity http://purl.obolibrary.org/obo/GO_0019806 GO:0019803 biolink:BiologicalProcess peptidyl-aspartic acid carboxylation The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid. RESID:AA0304 go.json http://purl.obolibrary.org/obo/GO_0019803 gocheck_do_not_annotate GO:0019804 biolink:CellularComponent obsolete quinolinate synthetase complex OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate. go.json quinolinate synthetase complex True http://purl.obolibrary.org/obo/GO_0019804 GO:0019801 biolink:BiologicalProcess cyclization of asparagine involved in intein-mediated protein splicing The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing. RESID:AA0302 go.json cyclization of asparagine, during protein splicing http://purl.obolibrary.org/obo/GO_0019801 GO:0019802 biolink:BiologicalProcess cyclization of glutamine involved in intein-mediated protein splicing The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing. RESID:AA0303 go.json cyclization of glutamine, during protein splicing http://purl.obolibrary.org/obo/GO_0019802 GO:0019800 biolink:BiologicalProcess peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain. RESID:AA0219 go.json peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan http://purl.obolibrary.org/obo/GO_0019800 gocheck_do_not_annotate GO:0030378 biolink:MolecularActivity serine racemase activity Catalysis of the synthesis of free D-serine from L-serine. EC:5.1.1.18|MetaCyc:5.1.1.18-RXN|RHEA:10980|Reactome:R-HSA-9014766 go.json http://purl.obolibrary.org/obo/GO_0030378 GO:0030379 biolink:MolecularActivity neurotensin receptor activity, non-G protein-coupled Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins. go.json neurotensin receptor activity, non G protein coupled|neurotensin receptor activity, non-G-protein coupled|non G protein coupled neurotensin receptor activity|non-G-protein coupled neurotensin receptor activity|non-G-protein-coupled neurotensin receptor activity http://purl.obolibrary.org/obo/GO_0030379 GO:0030376 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030376 GO:0030377 biolink:MolecularActivity urokinase plasminogen activator receptor activity Combining with the urokinase plasminogen activator to initiate a change in cell activity. Wikipedia:Urokinase_receptor go.json U-plasminogen activator receptor activity|uPAR|urokinase plasminogen activator receptor http://purl.obolibrary.org/obo/GO_0030377 GO:0030374 biolink:MolecularActivity nuclear receptor coactivator activity A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. go.json ligand-activated RNA polymerase II transcription factor binding transcription factor activity|ligand-dependent nuclear receptor transcription co-activator activity|ligand-dependent nuclear receptor transcription coactivator activity|nuclear receptor transcription coactivator activity|transcription factor activity, ligand-activated RNA polymerase II transcription factor binding http://purl.obolibrary.org/obo/GO_0030374 GO:0030375 biolink:MolecularActivity obsolete thyroid hormone receptor coactivator activity OBSOLETE. The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. go.json thyroid hormone receptor activator activity|thyroid hormone receptor co-activator activity True http://purl.obolibrary.org/obo/GO_0030375 GO:0030372 biolink:MolecularActivity high molecular weight B cell growth factor receptor binding Binding to a high molecular weight B cell growth factor receptor. go.json high molecular weight B cell growth factor receptor ligand|high molecular weight B lymphocyte growth factor receptor binding|high molecular weight B-cell growth factor receptor binding|high molecular weight B-lymphocyte growth factor receptor binding http://purl.obolibrary.org/obo/GO_0030372 GO:0030373 biolink:MolecularActivity high molecular weight B cell growth factor receptor activity Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity. go.json HMW-BCGF receptor|high molecular weight B lymphocyte growth factor receptor activity|high molecular weight B-cell growth factor receptor activity|high molecular weight B-lymphocyte growth factor receptor activity http://purl.obolibrary.org/obo/GO_0030373 GO:0030370 biolink:MolecularActivity intercellular adhesion molecule-3 receptor binding Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1. go.json ICAM-3 receptor binding|ICAM-3 receptor ligand|intercellular adhesion molecule-3 receptor ligand http://purl.obolibrary.org/obo/GO_0030370 GO:0030371 biolink:MolecularActivity translation repressor activity Antagonizes ribosome-mediated translation of mRNA into a polypeptide. go.json http://purl.obolibrary.org/obo/GO_0030371 GO:0030369 biolink:MolecularActivity ICAM-3 receptor activity Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. go.json http://purl.obolibrary.org/obo/GO_0030369 GO:0030367 biolink:MolecularActivity interleukin-17 receptor binding Binding to an interleukin-17 receptor. go.json IL-17|interleukin-17 receptor ligand http://purl.obolibrary.org/obo/GO_0030367 GO:0030368 biolink:MolecularActivity interleukin-17 receptor activity Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Wikipedia:Interleukin-17_receptor go.json IL-17 receptor activity|IL-17R http://purl.obolibrary.org/obo/GO_0030368 GO:0030365 biolink:MolecularActivity obsolete cleavage stimulation factor activity OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide. go.json CstF|cleavage stimulation factor activity True http://purl.obolibrary.org/obo/GO_0030365 GO:0030366 biolink:MolecularActivity molybdopterin synthase activity Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. EC:2.8.1.12|RHEA:26333|Reactome:R-HSA-947541 go.json http://purl.obolibrary.org/obo/GO_0030366 GO:0030363 biolink:MolecularActivity obsolete pre-mRNA cleavage factor activity OBSOLETE. Any activity required for the process of mRNA cleavage. go.json pre-mRNA cleavage factor activity True http://purl.obolibrary.org/obo/GO_0030363 GO:0030364 biolink:MolecularActivity obsolete cleavage and polyadenylylation specificity factor activity OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions. go.json CPSF|cleavage and polyadenylation specificity factor activity|cleavage and polyadenylylation specificity factor activity|cleavage/polyadenylation specificity factor activity True http://purl.obolibrary.org/obo/GO_0030364 GO:0030361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030361 GO:0030362 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030362 GO:0030360 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030360 GO:0030358 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030358 GO:0030359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030359 GO:0030356 biolink:MolecularActivity obsolete small cytoplasmic ribonucleoprotein OBSOLETE. (Was not defined before being made obsolete). go.json scRNP|small cytoplasmic ribonucleoprotein True http://purl.obolibrary.org/obo/GO_0030356 GO:0030357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030357 GO:0005396 biolink:MolecularActivity obsolete transmembrane conductance regulator activity OBSOLETE. (Was not defined before being made obsolete). go.json transmembrane conductance regulator activity True http://purl.obolibrary.org/obo/GO_0005396 GO:0005395 biolink:MolecularActivity obsolete eye pigment precursor transporter activity OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out). go.json True http://purl.obolibrary.org/obo/GO_0005395 GO:0030354 biolink:MolecularActivity melanin-concentrating hormone activity The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals. go.json http://purl.obolibrary.org/obo/GO_0030354 GO:0030355 biolink:MolecularActivity obsolete small nucleolar ribonucleoprotein OBSOLETE. (Was not defined before being made obsolete). go.json small nucleolar ribonucleoprotein|snoRNP True http://purl.obolibrary.org/obo/GO_0030355 GO:0030352 biolink:MolecularActivity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0030352 GO:0030353 biolink:MolecularActivity fibroblast growth factor receptor antagonist activity Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist. go.json FGF receptor antagonist activity|FGFR antagonist activity http://purl.obolibrary.org/obo/GO_0030353 GO:0030350 biolink:MolecularActivity iron-responsive element binding Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. go.json IRE binding http://purl.obolibrary.org/obo/GO_0030350 GO:0030351 biolink:MolecularActivity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate. Reactome:R-HSA-1855163 go.json http://purl.obolibrary.org/obo/GO_0030351 GO:0030349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030349 GO:0030347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030347 GO:0030348 biolink:MolecularActivity syntaxin-3 binding Binding to a syntaxin-3 SNAP receptor. go.json http://purl.obolibrary.org/obo/GO_0030348 GO:0030345 biolink:MolecularActivity structural constituent of tooth enamel The action of a molecule that contributes to the structural integrity of tooth enamel. go.json http://purl.obolibrary.org/obo/GO_0030345 GO:0030346 biolink:MolecularActivity protein phosphatase 2B binding Binding to a protein phosphatase 2B. go.json calcineurin binding|protein phosphatase 3 binding http://purl.obolibrary.org/obo/GO_0030346 GO:0030343 biolink:MolecularActivity vitamin D3 25-hydroxylase activity Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. MetaCyc:RXN-9829|RHEA:32903|Reactome:R-HSA-209845|Reactome:R-HSA-5602147 go.json cholecalciferol 25-hydroxylase activity http://purl.obolibrary.org/obo/GO_0030343 GO:0030344 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030344 GO:0030341 biolink:MolecularActivity chondroitin AC lyase activity Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. EC:4.2.2.5|MetaCyc:4.2.2.5-RXN go.json ChnAC|chondroitin AC eliminase activity|chondroitin lyase activity|chondroitin sulfate lyase activity|chondroitinase AC|chondroitinase activity http://purl.obolibrary.org/obo/GO_0030341 GO:0030342 biolink:MolecularActivity 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). Reactome:R-HSA-209765|Reactome:R-HSA-211950|Reactome:R-HSA-5602004 go.json 1,25-(OH)2D3 24-hydroxylase activity|calcitriol 24-hydroxylase activity http://purl.obolibrary.org/obo/GO_0030342 GO:0030340 biolink:MolecularActivity hyaluronate lyase activity Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. EC:4.2.2.1|MetaCyc:HYALURONATE-LYASE-RXN|RHEA:50240 go.json glucuronoglycosaminoglycan lyase activity|hyaluronidase [but cf. EC:3.2.1.35 (hyalurononglucosaminidase) and EC:3.2.1.36 (hyaluronoglucuronidase)]|hyaluronidase activity|mucinase activity|spreading factor activity http://purl.obolibrary.org/obo/GO_0030340 GO:0030338 biolink:MolecularActivity CMP-N-acetylneuraminate monooxygenase activity Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O. EC:1.14.18.2|MetaCyc:1.14.18.2-RXN|RHEA:16145 go.json CMP-N-acetylneuraminate hydroxylase activity|CMP-N-acetylneuraminic acid hydroxylase activity|CMP-Neu5Ac hydroxylase activity|cytidine monophosphoacetylneuraminate monooxygenase activity http://purl.obolibrary.org/obo/GO_0030338 GO:0030339 biolink:MolecularActivity fatty-acyl-ethyl-ester synthase activity Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol. EC:3.1.1.67|MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN|RHEA:16641 go.json FAEE synthase activity|FAEES activity|fatty-acyl ethyl ester synthase|long-chain-fatty-acyl-ethyl-ester acylhydrolase activity http://purl.obolibrary.org/obo/GO_0030339 GO:0030336 biolink:BiologicalProcess negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. go.json down regulation of cell migration|down-regulation of cell migration|downregulation of cell migration|inhibition of cell migration http://purl.obolibrary.org/obo/GO_0030336 GO:0030337 biolink:MolecularActivity DNA polymerase processivity factor activity An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. go.json processivity clamp|sliding clamp http://purl.obolibrary.org/obo/GO_0030337 GO:0005378 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005378 GO:0030334 biolink:BiologicalProcess regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration. go.json http://purl.obolibrary.org/obo/GO_0030334 GO:0030335 biolink:BiologicalProcess positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration. go.json activation of cell migration|stimulation of cell migration|up regulation of cell migration|up-regulation of cell migration|upregulation of cell migration http://purl.obolibrary.org/obo/GO_0030335 GO:0005379 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005379 GO:0005376 biolink:MolecularActivity obsolete plasma membrane copper transporter OBSOLETE. (Was not defined before being made obsolete). go.json plasma membrane copper transporter True http://purl.obolibrary.org/obo/GO_0005376 GO:0005377 biolink:MolecularActivity obsolete intracellular copper ion transporter OBSOLETE. (Was not defined before being made obsolete). go.json intracellular copper ion transporter|intracellular copper transporter True http://purl.obolibrary.org/obo/GO_0005377 GO:0005375 biolink:MolecularActivity copper ion transmembrane transporter activity Enables the transfer of copper (Cu) ions from one side of a membrane to the other. RHEA:28703|Reactome:R-HSA-437300 go.json copper uptake transmembrane transporter activity|intracellular copper ion transporter|plasma membrane copper transporter http://purl.obolibrary.org/obo/GO_0005375 GO:0005372 biolink:MolecularActivity water transmembrane transporter activity Enables the transfer of water (H2O) from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0005372 GO:0005373 biolink:MolecularActivity obsolete heavy metal ion porter activity OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane. go.json heavy metal ion porter activity|metal ion transporter True http://purl.obolibrary.org/obo/GO_0005373 GO:0005370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005370 GO:0005371 biolink:MolecularActivity tricarboxylate secondary active transmembrane transporter activity Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json tricarboxylate carrier activity http://purl.obolibrary.org/obo/GO_0005371 GO:0005380 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005380 GO:0030332 biolink:MolecularActivity cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. go.json http://purl.obolibrary.org/obo/GO_0030332 GO:0030333 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030333 GO:0030330 biolink:BiologicalProcess DNA damage response, signal transduction by p53 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. go.json DNA damage response, activation of p53|TP53 signaling pathway|p53 signaling pathway|p53-mediated DNA damage response http://purl.obolibrary.org/obo/GO_0030330 GO:0030331 biolink:MolecularActivity nuclear estrogen receptor binding Binding to a nuclear estrogen receptor. go.json estrogen receptor binding http://purl.obolibrary.org/obo/GO_0030331 GO:0030329 biolink:BiologicalProcess prenylcysteine metabolic process The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. go.json prenylcysteine metabolism http://purl.obolibrary.org/obo/GO_0030329 GO:0030327 biolink:BiologicalProcess prenylated protein catabolic process The chemical reactions and pathways resulting in the breakdown of prenylated proteins. go.json prenylated protein breakdown|prenylated protein catabolism|prenylated protein degradation http://purl.obolibrary.org/obo/GO_0030327 GO:0030328 biolink:BiologicalProcess prenylcysteine catabolic process The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. go.json prenylcysteine breakdown|prenylcysteine catabolism|prenylcysteine degradation http://purl.obolibrary.org/obo/GO_0030328 GO:0030325 biolink:BiologicalProcess adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. go.json interrenal gland http://purl.obolibrary.org/obo/GO_0030325 GO:0030326 biolink:BiologicalProcess embryonic limb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. go.json http://purl.obolibrary.org/obo/GO_0030326 GO:0030323 biolink:BiologicalProcess respiratory tube development The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. go.json http://purl.obolibrary.org/obo/GO_0030323 GO:0030324 biolink:BiologicalProcess lung development The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. go.json http://purl.obolibrary.org/obo/GO_0030324 GO:0005388 biolink:MolecularActivity P-type calcium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). EC:7.2.2.10|MetaCyc:TRANS-RXN-194|RHEA:18105|Reactome:R-HSA-418309|Reactome:R-HSA-418365|Reactome:R-HSA-427910|Reactome:R-HSA-936883|Reactome:R-HSA-9662114|Reactome:R-HSA-9664214 go.json ATP-dependent calcium transmembrane transporter activity|ATPase-coupled calcium transmembrane transporter activity|Ca(2+)-transporting ATPase activity|Ca2+-transporting ATPase activity|calcium efflux ATPase|calcium pump|calcium transmembrane transporter activity, phosphorylative mechanism|calcium transporting ATPase activity|calcium-translocating P-type ATPase activity|calcium-transporting ATPase activity|sarco(endo)plasmic reticulum Ca2+-ATPase http://purl.obolibrary.org/obo/GO_0005388 GO:0005385 biolink:MolecularActivity zinc ion transmembrane transporter activity Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. RHEA:29351|Reactome:R-HSA-435366|Reactome:R-HSA-435375|Reactome:R-HSA-437084|Reactome:R-HSA-437085|Reactome:R-HSA-437136|Reactome:R-HSA-437139|Reactome:R-HSA-442317|Reactome:R-HSA-442345|Reactome:R-HSA-442387|Reactome:R-HSA-442393|Reactome:R-HSA-442405|Reactome:R-HSA-442422|Reactome:R-HSA-5654125|Reactome:R-HSA-9820566 go.json cobalt, zinc uptake permease activity|zinc, cadmium uptake permease activity|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity|zinc, iron permease activity http://purl.obolibrary.org/obo/GO_0005385 GO:0005386 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005386 GO:0005384 biolink:MolecularActivity manganese ion transmembrane transporter activity Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. RHEA:28699|Reactome:R-HSA-8959798 go.json http://purl.obolibrary.org/obo/GO_0005384 GO:0005381 biolink:MolecularActivity iron ion transmembrane transporter activity Enables the transfer of iron (Fe) ions from one side of a membrane to the other. Reactome:R-HSA-435349|Reactome:R-HSA-5623558|Reactome:R-HSA-5655733|Reactome:R-HSA-904830|Reactome:R-HSA-917936 go.json iron cation channel activity|iron channel activity|iron transporter activity|multicopper ferroxidase iron transport mediator activity|transmembrane iron ion permease activity|transmembrane iron permease activity|zinc, iron permease activity http://purl.obolibrary.org/obo/GO_0005381 GO:0005382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005382 GO:0005390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005390 GO:0005391 biolink:MolecularActivity P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). EC:7.2.2.13|MetaCyc:3.6.3.9-RXN|RHEA:18353|Reactome:R-HSA-936897|TC:3.A.3.1.1|Wikipedia:ATPase,_Na%2B/K%2B_transporting,_alpha_1 go.json Na(+)/K(+)-ATPase activity|Na(+)/K(+)-exchanging ATPase activity|Na+,K+-ATPase activity|Na+/K+-ATPase activity|Na+/K+-exchanging ATPase activity|Na,K-activated ATPase activity|P-type sodium:potassium-exchanging ATPase activity|sodium pump|sodium/potassium-exchanging ATPase activity|sodium/potassium-transporting ATPase activity|sodium:potassium exchanging ATPase activity|sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_0005391 RO:0002356 biolink:OntologyClass results in specification of RO:0002356 go.json http://purl.obolibrary.org/obo/RO_0002356 GO:0030321 biolink:BiologicalProcess transepithelial chloride transport The directed movement of chloride ions from one side of an epithelium to the other. go.json http://purl.obolibrary.org/obo/GO_0030321 GO:0030322 biolink:BiologicalProcess stabilization of membrane potential The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json http://purl.obolibrary.org/obo/GO_0030322 GO:0030320 biolink:BiologicalProcess obsolete cellular monovalent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. go.json True http://purl.obolibrary.org/obo/GO_0030320 GO:0030318 biolink:BiologicalProcess melanocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. go.json melanocyte cell differentiation|melanophore differentiation http://purl.obolibrary.org/obo/GO_0030318 GO:0030319 biolink:BiologicalProcess obsolete cellular di-, tri-valent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell. go.json cellular di-, tri-valent inorganic anion homeostasis True http://purl.obolibrary.org/obo/GO_0030319 GO:0030316 biolink:BiologicalProcess osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. go.json osteoclast cell differentiation http://purl.obolibrary.org/obo/GO_0030316 GO:0030317 biolink:BiologicalProcess flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. Wikipedia:Sperm_motility go.json flagellated sperm movement|sperm flagellum movement|sperm flagellum movement involved in flagellated sperm motility|sperm flagellum movement involved in flagellated sperm movement|sperm motility|sperm movement http://purl.obolibrary.org/obo/GO_0030317 GO:0030314 biolink:CellularComponent junctional membrane complex Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules). go.json triad junction http://purl.obolibrary.org/obo/GO_0030314 GO:0005358 biolink:MolecularActivity high-affinity glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high-affinity hydrogen/glucose transporter activity|high-affinity hydrogen:glucose symporter activity|high-affinity hydrogen:glucose transporter activity http://purl.obolibrary.org/obo/GO_0005358 GO:0030315 biolink:CellularComponent T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. Wikipedia:T-tubule go.json transverse tubule|triad http://purl.obolibrary.org/obo/GO_0030315 GO:0005359 biolink:MolecularActivity low-affinity glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. go.json low-affinity hydrogen/glucose transporter activity|low-affinity hydrogen:glucose symporter activity|low-affinity hydrogen:glucose transporter activity http://purl.obolibrary.org/obo/GO_0005359 GO:0030312 biolink:CellularComponent external encapsulating structure A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. go.json http://purl.obolibrary.org/obo/GO_0030312 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_plant GO:0005356 biolink:MolecularActivity glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. go.json hydrogen:glucose symporter activity|hydrogen:glucose transporter activity|transepithelial hydrogen/glucose transporter activity|transepithelial hydrogen:glucose symporter activity|transepithelial hydrogen:glucose transporter activity http://purl.obolibrary.org/obo/GO_0005356 GO:0030313 biolink:CellularComponent cell envelope An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. Wikipedia:Cell_envelope go.json http://purl.obolibrary.org/obo/GO_0030313 goslim_pir GO:0005357 biolink:MolecularActivity obsolete constitutive glucose:proton symporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. go.json constitutive hydrogen/glucose transporter activity|constitutive hydrogen:glucose symporter activity|constitutive hydrogen:glucose transporter activity True http://purl.obolibrary.org/obo/GO_0005357 GO:0005354 biolink:MolecularActivity galactose transmembrane transporter activity Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. RHEA:34915 go.json galactose/glucose (methylgalactoside) porter activity http://purl.obolibrary.org/obo/GO_0005354 GO:0005355 biolink:MolecularActivity glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. Reactome:R-HSA-499981|Reactome:R-HSA-5653873 go.json galactose/glucose (methylgalactoside) porter activity|glucose permease activity|lactose/glucose efflux transporter activity http://purl.obolibrary.org/obo/GO_0005355 RO:0002353 biolink:OntologyClass output of RO:0002353 go.json http://purl.obolibrary.org/obo/RO_0002353 GO:0005352 biolink:MolecularActivity alpha-glucoside:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose. go.json alpha-glucoside:hydrogen symporter activity|general alpha-glucoside transporter activity|general alpha-glucoside:hydrogen symporter activity|general alpha-glucoside:proton symporter activity http://purl.obolibrary.org/obo/GO_0005352 RO:0002355 biolink:OntologyClass results in structural organization of RO:0002355 go.json http://purl.obolibrary.org/obo/RO_0002355 GO:0005353 biolink:MolecularActivity fructose transmembrane transporter activity Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. Reactome:R-HSA-189222 go.json fructose permease activity|fructose porter activity http://purl.obolibrary.org/obo/GO_0005353 GO:0005350 biolink:MolecularActivity pyrimidine nucleobase transmembrane transporter activity Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. go.json pyrimidine base transmembrane transporter activity|pyrimidine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005350 GO:0005351 biolink:MolecularActivity carbohydrate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). TC:2.A.1.1 go.json cation/sugar symporter activity|hydrogen:sugar symporter activity|hydrogen:sugar transporter activity|lactose/glucose efflux transporter activity|proton:sugar symporter activity|sugar efflux transmembrane transporter activity|sugar porter activity|sugar transporter|sugar:hydrogen ion symporter activity|sugar:hydrogen symporter activity|sugar:proton symporter activity http://purl.obolibrary.org/obo/GO_0005351 RO:0002349 biolink:OntologyClass results in determination of RO:0002349 go.json http://purl.obolibrary.org/obo/RO_0002349 RO:0002348 biolink:OntologyClass results in commitment to RO:0002348 go.json http://purl.obolibrary.org/obo/RO_0002348 GO:0030310 biolink:BiologicalProcess poly-N-acetyllactosamine catabolic process The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. go.json poly-N-acetyllactosamine breakdown|poly-N-acetyllactosamine catabolism|poly-N-acetyllactosamine degradation http://purl.obolibrary.org/obo/GO_0030310 GO:0030311 biolink:BiologicalProcess poly-N-acetyllactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. go.json poly-N-acetyllactosamine anabolism|poly-N-acetyllactosamine biosynthesis|poly-N-acetyllactosamine formation|poly-N-acetyllactosamine synthesis http://purl.obolibrary.org/obo/GO_0030311 GO:0019991 biolink:BiologicalProcess septate junction assembly The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space. go.json http://purl.obolibrary.org/obo/GO_0019991 GO:0019992 biolink:MolecularActivity diacylglycerol binding Binding to a diacylglycerol, a diester of glycerol and two fatty acids. go.json http://purl.obolibrary.org/obo/GO_0019992 GO:0019990 biolink:BiologicalProcess pteridine catabolic process The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. go.json pteridine breakdown|pteridine catabolism|pteridine degradation http://purl.obolibrary.org/obo/GO_0019990 GO:0030307 biolink:BiologicalProcess positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth. go.json activation of cell growth|stimulation of cell growth|up regulation of cell growth|up-regulation of cell growth|upregulation of cell growth http://purl.obolibrary.org/obo/GO_0030307 GO:0030308 biolink:BiologicalProcess negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. go.json down regulation of cell growth|down-regulation of cell growth|downregulation of cell growth|inhibition of cell growth http://purl.obolibrary.org/obo/GO_0030308 GO:0030305 biolink:MolecularActivity heparanase activity Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. Reactome:R-HSA-1667005 go.json heparinase activity http://purl.obolibrary.org/obo/GO_0030305 GO:0030306 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030306 GO:0030303 biolink:MolecularActivity obsolete stromelysin 2 activity OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak. go.json MMP-10|matrix metalloproteinase 10 activity|proteoglycanase 2|stromelysin 2 activity|transin 2 activity True http://purl.obolibrary.org/obo/GO_0030303 GO:0005369 biolink:MolecularActivity taurine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). go.json sodium/chloride-dependent taurine transporter http://purl.obolibrary.org/obo/GO_0005369 GO:0030304 biolink:MolecularActivity obsolete trypsin inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin. go.json trypsin inhibitor activity True http://purl.obolibrary.org/obo/GO_0030304 GO:0005367 biolink:MolecularActivity myo-inositol:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in). Reactome:R-HSA-429663 go.json myo-inositol-sodium cotransporter activity http://purl.obolibrary.org/obo/GO_0005367 GO:0030301 biolink:BiologicalProcess cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0030301 GO:0030302 biolink:BiologicalProcess deoxynucleotide transport The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell. go.json http://purl.obolibrary.org/obo/GO_0030302 GO:0005368 biolink:MolecularActivity taurine transmembrane transporter activity Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. go.json http://purl.obolibrary.org/obo/GO_0005368 RO:0002341 biolink:OntologyClass results in transport along RO:0002341 go.json http://purl.obolibrary.org/obo/RO_0002341 GO:0005365 biolink:MolecularActivity myo-inositol transmembrane transporter activity Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. go.json vitamin Bh transporter activity http://purl.obolibrary.org/obo/GO_0005365 GO:0005366 biolink:MolecularActivity myo-inositol:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in). RHEA:60364|Reactome:R-HSA-429101 go.json hydrogen/myo-inositol transporter activity|myo-inositol:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0005366 RO:0002342 biolink:OntologyClass results in transport across RO:0002342 go.json http://purl.obolibrary.org/obo/RO_0002342 RO:0002343 biolink:OntologyClass results in growth of RO:0002343 go.json http://purl.obolibrary.org/obo/RO_0002343 GO:0005363 biolink:MolecularActivity maltose transmembrane transporter activity Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. RHEA:33171 go.json maltose porter activity http://purl.obolibrary.org/obo/GO_0005363 GO:0005364 biolink:MolecularActivity maltose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in). go.json hydrogen/maltose transporter activity|maltose permease|maltose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0005364 RO:0002344 biolink:OntologyClass results in transport to from or in RO:0002344 go.json http://purl.obolibrary.org/obo/RO_0002344 GO:0005361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005361 GO:0005362 biolink:MolecularActivity low-affinity glucose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Reactome:R-HSA-429567 go.json low-affinity glucose-sodium cotransporter activity http://purl.obolibrary.org/obo/GO_0005362 GO:0030309 biolink:BiologicalProcess poly-N-acetyllactosamine metabolic process The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. go.json poly-N-acetyllactosamine metabolism http://purl.obolibrary.org/obo/GO_0030309 GO:0005360 biolink:MolecularActivity insulin-responsive glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. go.json insulin-responsive hydrogen:glucose symporter activity|insulin-responsive hydrogen:glucose transporter activity|transepithelial hydrogen/glucose transporter activity http://purl.obolibrary.org/obo/GO_0005360 RO:0002338 biolink:OntologyClass has target start location RO:0002338 go.json http://purl.obolibrary.org/obo/RO_0002338 RO:0002339 biolink:OntologyClass has target end location RO:0002339 go.json http://purl.obolibrary.org/obo/RO_0002339 RO:0002334 biolink:OntologyClass regulated by RO:0002334 go.json http://purl.obolibrary.org/obo/RO_0002334 RO:0002335 biolink:OntologyClass negatively regulated by RO:0002335 go.json http://purl.obolibrary.org/obo/RO_0002335 RO:0002336 biolink:OntologyClass positively regulated by RO:0002336 go.json http://purl.obolibrary.org/obo/RO_0002336 GO:0030300 biolink:BiologicalProcess regulation of intestinal cholesterol absorption Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption. go.json http://purl.obolibrary.org/obo/GO_0030300 RO:0002332 biolink:OntologyClass regulates levels of RO:0002332 go.json http://purl.obolibrary.org/obo/RO_0002332 RO:0002315 biolink:OntologyClass results in acquisition of features of RO:0002315 go.json http://purl.obolibrary.org/obo/RO_0002315 RO:0002305 biolink:OntologyClass causally upstream of, negative effect RO:0002305 go.json http://purl.obolibrary.org/obo/RO_0002305 RO:0002304 biolink:OntologyClass causally upstream of, positive effect RO:0002304 go.json http://purl.obolibrary.org/obo/RO_0002304 GO:0030390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030390 GO:0030391 biolink:BiologicalProcess fructosamine biosynthetic process The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. go.json fructosamine anabolism|fructosamine biosynthesis|fructosamine formation|fructosamine synthesis http://purl.obolibrary.org/obo/GO_0030391 GO:0030398 biolink:BiologicalProcess obsolete peroxisomal membrane disassembly OBSOLETE. The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation. go.json peroxisomal membrane breakdown|peroxisomal membrane catabolism|peroxisomal membrane degradation True http://purl.obolibrary.org/obo/GO_0030398 GO:0030399 biolink:BiologicalProcess autophagosome membrane disassembly The controlled breakdown of the membranes of autophagosomes. go.json autophagic membrane breakdown|autophagic membrane catabolism|autophagic membrane degradation|autophagic vacuole membrane disassembly http://purl.obolibrary.org/obo/GO_0030399 GO:0030396 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030396 GO:0030397 biolink:BiologicalProcess membrane disassembly The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. go.json membrane breakdown|membrane catabolism|membrane degradation http://purl.obolibrary.org/obo/GO_0030397 GO:0030394 biolink:BiologicalProcess fructoseglycine metabolic process The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group. go.json fructoseglycine metabolism http://purl.obolibrary.org/obo/GO_0030394 GO:0030395 biolink:MolecularActivity lactose binding Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. go.json http://purl.obolibrary.org/obo/GO_0030395 GO:0030392 biolink:BiologicalProcess fructosamine catabolic process The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. go.json fructosamine breakdown|fructosamine catabolism|fructosamine degradation http://purl.obolibrary.org/obo/GO_0030392 GO:0030393 biolink:BiologicalProcess fructoselysine metabolic process The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group. go.json fructoselysine metabolism http://purl.obolibrary.org/obo/GO_0030393 GO:0030389 biolink:BiologicalProcess fructosamine metabolic process The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. go.json fructosamine metabolism http://purl.obolibrary.org/obo/GO_0030389 GO:0030380 biolink:MolecularActivity interleukin-17E receptor binding Binding to an interleukin-17E receptor. go.json IL-17E|interleukin-17E receptor ligand http://purl.obolibrary.org/obo/GO_0030380 GO:0030387 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030387 GO:0030388 biolink:BiologicalProcess fructose 1,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. go.json fructose 1,6-bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0030388 GO:0030385 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030385 GO:0030386 biolink:CellularComponent ferredoxin-thioredoxin reductase complex A protein complex that possesses ferredoxin-thioredoxin reductase activity. go.json ferredoxin:thioredoxin reductase complex http://purl.obolibrary.org/obo/GO_0030386 GO:0030383 biolink:BiologicalProcess obsolete host-pathogen interaction OBSOLETE. Any interaction between a pathogen and its host organism. go.json host-pathogen interaction True http://purl.obolibrary.org/obo/GO_0030383 GO:0030384 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030384 GO:0030381 biolink:BiologicalProcess chorion-containing eggshell pattern formation The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects. go.json http://purl.obolibrary.org/obo/GO_0030381 GO:0030382 biolink:BiologicalProcess sperm mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm. go.json sperm mitochondria organisation|sperm mitochondria organization and biogenesis|sperm mitochondrion organization and biogenesis http://purl.obolibrary.org/obo/GO_0030382 GO:0019908 biolink:CellularComponent nuclear cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the nucleus. go.json CDK holoenzyme http://purl.obolibrary.org/obo/GO_0019908 GO:0019909 biolink:MolecularActivity [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase. EC:3.1.3.43 go.json [pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0019909 GO:0019906 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019906 GO:0019907 biolink:CellularComponent cyclin-dependent protein kinase activating kinase holoenzyme complex A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. go.json CAK complex|CDK-activating kinase complex http://purl.obolibrary.org/obo/GO_0019907 GO:0019904 biolink:MolecularActivity protein domain specific binding Binding to a specific domain of a protein. go.json protein domain-specific binding http://purl.obolibrary.org/obo/GO_0019904 goslim_chembl GO:0019905 biolink:MolecularActivity syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. go.json syntaxin-13 binding|syntaxin-2 binding|syntaxin-5 binding|syntaxin-6 binding http://purl.obolibrary.org/obo/GO_0019905 GO:0019902 biolink:MolecularActivity phosphatase binding Binding to a phosphatase. go.json http://purl.obolibrary.org/obo/GO_0019902 GO:0019903 biolink:MolecularActivity protein phosphatase binding Binding to a protein phosphatase. go.json http://purl.obolibrary.org/obo/GO_0019903 GO:0019900 biolink:MolecularActivity kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. go.json http://purl.obolibrary.org/obo/GO_0019900 GO:0019901 biolink:MolecularActivity protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. go.json http://purl.obolibrary.org/obo/GO_0019901 GO:0005338 biolink:MolecularActivity nucleotide-sugar transmembrane transporter activity Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. Reactome:R-HSA-744230|Reactome:R-HSA-744231|Reactome:R-HSA-9792608 go.json http://purl.obolibrary.org/obo/GO_0005338 GO:0005339 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005339 GO:0005336 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005336 GO:0005337 biolink:MolecularActivity nucleoside transmembrane transporter activity Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. Reactome:R-HSA-109527|Reactome:R-HSA-109529|Reactome:R-HSA-109534|Reactome:R-HSA-109536|Reactome:R-HSA-5628807|Reactome:R-HSA-727740|Reactome:R-HSA-727749|Reactome:R-HSA-727767|Reactome:R-HSA-727768|Reactome:R-HSA-9751024|Reactome:R-HSA-9754929|Reactome:R-HSA-9755015|Reactome:R-HSA-9755035 go.json intracellular nucleoside transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005337 GO:0005334 biolink:MolecularActivity norepinephrine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in). Reactome:R-HSA-443997|Reactome:R-HSA-5659764|Wikipedia:Norepinephrine_transporter go.json levarterenol transporter activity|noradrenaline transporter activity|norepinephrine transmembrane transporter activity|norepinephrine:sodium:chloride symporter activity|sodium/norepinephrine symporter activity http://purl.obolibrary.org/obo/GO_0005334 GO:0005335 biolink:MolecularActivity serotonin:sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in). RHEA:51196|Reactome:R-HSA-444008|TC:2.A.22.1.1 go.json serotonin transmembrane transporter activity|serotonin:sodium symporter activity|sodium/serotonin symporter activity http://purl.obolibrary.org/obo/GO_0005335 GO:0005332 biolink:MolecularActivity gamma-aminobutyric acid:sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). Reactome:R-HSA-444007|TC:2.A.22.3.2 go.json 4-aminobutanoate:sodium symporter activity|4-aminobutyrate:sodium symporter activity|GABA:sodium symporter activity|betaine/GABA:sodium symporter activity|gamma-aminobutyric acid:sodium symporter activity|sodium/chloride-dependent GABA transporter activity http://purl.obolibrary.org/obo/GO_0005332 GO:0005333 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005333 GO:0005330 biolink:MolecularActivity dopamine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in). go.json dopamine transmembrane transporter activity|dopamine:sodium:chloride symporter activity|sodium/dopamine symporter activity http://purl.obolibrary.org/obo/GO_0005330 GO:0005331 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005331 GO:0019979 biolink:MolecularActivity interleukin-4 binding Binding to interleukin-4. go.json IL-4 binding http://purl.obolibrary.org/obo/GO_0019979 GO:0019977 biolink:MolecularActivity interleukin-21 binding Binding to interleukin-21. go.json IL-21 binding http://purl.obolibrary.org/obo/GO_0019977 GO:0019978 biolink:MolecularActivity interleukin-3 binding Binding to interleukin-3. go.json IL-3 binding http://purl.obolibrary.org/obo/GO_0019978 GO:0019975 biolink:MolecularActivity interleukin-17 binding Binding to a member of the interleukin-17 family of cytokines. go.json IL-17 binding http://purl.obolibrary.org/obo/GO_0019975 GO:0019976 biolink:MolecularActivity interleukin-2 binding Binding to interleukin-2. go.json IL-2 binding http://purl.obolibrary.org/obo/GO_0019976 GO:0019973 biolink:MolecularActivity interleukin-13 binding Binding to interleukin-13. go.json IL-13 binding http://purl.obolibrary.org/obo/GO_0019973 GO:0019974 biolink:MolecularActivity obsolete interleukin-14 binding OBSOLETE. Binding to interleukin-14. go.json IL-14 binding True http://purl.obolibrary.org/obo/GO_0019974 GO:0019972 biolink:MolecularActivity interleukin-12 binding Binding to interleukin-12. go.json IL-12 binding http://purl.obolibrary.org/obo/GO_0019972 GO:0019970 biolink:MolecularActivity interleukin-11 binding Binding to interleukin-11. go.json IL-11 binding http://purl.obolibrary.org/obo/GO_0019970 GO:0005349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005349 GO:0005347 biolink:MolecularActivity ATP transmembrane transporter activity Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. Reactome:R-HSA-9717392 go.json http://purl.obolibrary.org/obo/GO_0005347 GO:0005348 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005348 GO:0005345 biolink:MolecularActivity purine nucleobase transmembrane transporter activity Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. go.json purine base transmembrane transporter activity|purine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005345 GO:0005346 biolink:MolecularActivity purine ribonucleotide transmembrane transporter activity Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0005346 GO:0005343 biolink:MolecularActivity organic acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). Reactome:R-HSA-8876312 go.json sodium/chloride-dependent organic acid cotransporter activity|sodium:dicarboxylate/tricarboxylate symporter activity http://purl.obolibrary.org/obo/GO_0005343 GO:0005344 biolink:MolecularActivity oxygen carrier activity Binding to oxygen and delivering it to an acceptor molecule or a specific location. go.json globin|hemerythrin|hemocyanin|oxygen-carrying http://purl.obolibrary.org/obo/GO_0005344 GO:0005341 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005341 GO:0005342 biolink:MolecularActivity organic acid transmembrane transporter activity Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. go.json http://purl.obolibrary.org/obo/GO_0005342 GO:0005340 biolink:MolecularActivity nucleotide-sulfate transmembrane transporter activity Enables the transfer of nucleotide-sulfate from one side of a membrane to the other. go.json nucleotide-sulphate transporter activity http://purl.obolibrary.org/obo/GO_0005340 GO:0019988 biolink:BiologicalProcess charged-tRNA amino acid modification The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine. go.json charged tRNA amino acid modification|charged tRNA modification|charged-tRNA modification|pre-translational amino acid modification|pre-translational protein modification|pretranslation protein modification|pretranslational amino acid modification http://purl.obolibrary.org/obo/GO_0019988 GO:0019986 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019986 GO:0019987 biolink:BiologicalProcess obsolete negative regulation of anti-apoptosis OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis. go.json down regulation of anti-apoptosis|down-regulation of anti-apoptosis|downregulation of anti-apoptosis|inhibition of anti-apoptosis|negative regulation of anti-apoptosis True http://purl.obolibrary.org/obo/GO_0019987 GO:0019984 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019984 GO:0019985 biolink:BiologicalProcess translesion synthesis The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. go.json bypass DNA synthesis http://purl.obolibrary.org/obo/GO_0019985 GO:0019982 biolink:MolecularActivity interleukin-7 binding Binding to interleukin-7. go.json IL-7 binding http://purl.obolibrary.org/obo/GO_0019982 GO:0019983 biolink:MolecularActivity interleukin-9 binding Binding to interleukin-9. go.json IL-9 binding http://purl.obolibrary.org/obo/GO_0019983 GO:0019980 biolink:MolecularActivity interleukin-5 binding Binding to interleukin-5. go.json IL-5 binding http://purl.obolibrary.org/obo/GO_0019980 GO:0019981 biolink:MolecularActivity interleukin-6 binding Binding to interleukin-6. go.json IL-6 binding http://purl.obolibrary.org/obo/GO_0019981 GO:0005318 biolink:MolecularActivity obsolete phosphate:hydrogen symporter OBSOLETE. (Was not defined before being made obsolete). go.json phosphate:hydrogen symporter|phosphate:proton symporter activity True http://purl.obolibrary.org/obo/GO_0005318 GO:0005319 biolink:MolecularActivity lipid transporter activity Enables the directed movement of lipids into, out of or within a cell, or between cells. Reactome:R-HSA-1369028|Reactome:R-HSA-1369052|Reactome:R-HSA-174786|Reactome:R-HSA-5682285|Reactome:R-HSA-5682311|Reactome:R-HSA-5683672|Reactome:R-HSA-5683714|Reactome:R-HSA-5688397|Reactome:R-HSA-6801250|Reactome:R-HSA-8848053|Reactome:R-HSA-8866329 go.json apolipoprotein|lipophorin http://purl.obolibrary.org/obo/GO_0005319 GO:0005316 biolink:MolecularActivity high-affinity inorganic phosphate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity inorganic phosphate:sodium symporter activity|sodium/phosphate cotransporter activity http://purl.obolibrary.org/obo/GO_0005316 GO:0005317 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005317 GO:0005314 biolink:MolecularActivity high-affinity L-glutamate transmembrane transporter activity Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. RHEA:66336|Reactome:R-HSA-210404|Reactome:R-HSA-428015|Reactome:R-HSA-5625015|Reactome:R-HSA-5625029 go.json high-affinity glutamate transmembrane transporter activity|high-affinity glutamate transporter activity http://purl.obolibrary.org/obo/GO_0005314 GO:0005315 biolink:MolecularActivity inorganic phosphate transmembrane transporter activity Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json http://purl.obolibrary.org/obo/GO_0005315 GO:0005312 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005312 GO:0005313 biolink:MolecularActivity L-glutamate transmembrane transporter activity Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. RHEA:66336|Reactome:R-HSA-210444|Reactome:R-HSA-428052|Reactome:R-HSA-5624256 go.json L-glutamate transporter activity|glutamate transmembrane transporter activity|glutamate/aspartate porter activity|glutamate/aspartate:sodium symporter activity http://purl.obolibrary.org/obo/GO_0005313 GO:0005310 biolink:MolecularActivity dicarboxylic acid transmembrane transporter activity Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. Reactome:R-HSA-1614546|Reactome:R-HSA-372843 go.json dicarboxylate (succinate/fumarate/malate) antiporter activity|dicarboxylate carrier|dicarboxylic acid permease activity|sodium:dicarboxylate/tricarboxylate symporter activity http://purl.obolibrary.org/obo/GO_0005310 GO:0005311 biolink:MolecularActivity obsolete sodium:dicarboxylate/tricarboxylate symporter activity OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in). go.json sodium:dicarboxylate/tricarboxylate cotransporter activity|sodium:dicarboxylate/tricarboxylate symporter activity True http://purl.obolibrary.org/obo/GO_0005311 GO:0019959 biolink:MolecularActivity interleukin-8 binding Binding to interleukin-8. go.json IL-8 binding http://purl.obolibrary.org/obo/GO_0019959 GO:0019957 biolink:MolecularActivity C-C chemokine binding Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. go.json http://purl.obolibrary.org/obo/GO_0019957 GO:0019958 biolink:MolecularActivity C-X-C chemokine binding Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. go.json http://purl.obolibrary.org/obo/GO_0019958 GO:0019955 biolink:MolecularActivity cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. go.json IL binding|interleukin binding http://purl.obolibrary.org/obo/GO_0019955 GO:0019956 biolink:MolecularActivity chemokine binding Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. go.json http://purl.obolibrary.org/obo/GO_0019956 GO:0019953 biolink:BiologicalProcess sexual reproduction A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). Wikipedia:Sexual_reproduction go.json http://purl.obolibrary.org/obo/GO_0019953 GO:0019954 biolink:BiologicalProcess asexual reproduction A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells. Wikipedia:Asexual_reproduction go.json parthenogenesis http://purl.obolibrary.org/obo/GO_0019954 GO:0019951 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019951 GO:0019952 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019952 GO:0019950 biolink:BiologicalProcess obsolete SMT3-dependent protein catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein. go.json SMT3-dependent protein breakdown|SMT3-dependent protein catabolism|SMT3-dependent protein degradation True http://purl.obolibrary.org/obo/GO_0019950 GO:0005329 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005329 GO:0005328 biolink:MolecularActivity neurotransmitter:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). go.json sodium/neurotransmitter symporter activity http://purl.obolibrary.org/obo/GO_0005328 GO:0005325 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005325 GO:0005326 biolink:MolecularActivity neurotransmitter transmembrane transporter activity Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. Reactome:R-HSA-374896|Reactome:R-HSA-374919 go.json neurotransmitter transporter activity http://purl.obolibrary.org/obo/GO_0005326 GO:0005323 biolink:MolecularActivity obsolete very-low-density lipoprotein OBSOLETE. (Was not defined before being made obsolete). go.json VLDL|very-low-density lipoprotein True http://purl.obolibrary.org/obo/GO_0005323 GO:0005324 biolink:MolecularActivity long-chain fatty acid transporter activity Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. Reactome:R-HSA-2046087|Reactome:R-HSA-2046093|Reactome:R-HSA-382575|Reactome:R-HSA-390393|Reactome:R-HSA-434381|Reactome:R-HSA-5684043 go.json http://purl.obolibrary.org/obo/GO_0005324 GO:0005321 biolink:MolecularActivity obsolete high-density lipoprotein OBSOLETE. (Was not defined before being made obsolete). go.json HDL|high-density lipoprotein True http://purl.obolibrary.org/obo/GO_0005321 GO:0005322 biolink:MolecularActivity obsolete low-density lipoprotein OBSOLETE. (Was not defined before being made obsolete). go.json LDL|low-density lipoprotein True http://purl.obolibrary.org/obo/GO_0005322 GO:0005320 biolink:MolecularActivity obsolete apolipoprotein OBSOLETE. (Was not defined before being made obsolete). go.json apolipoprotein True http://purl.obolibrary.org/obo/GO_0005320 GO:0019968 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019968 GO:0019969 biolink:MolecularActivity interleukin-10 binding Binding to interleukin-10. go.json IL-10 binding http://purl.obolibrary.org/obo/GO_0019969 GO:0019966 biolink:MolecularActivity interleukin-1 binding Binding to interleukin-1. go.json IL-1 binding http://purl.obolibrary.org/obo/GO_0019966 GO:0019967 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019967 GO:0019964 biolink:MolecularActivity type II interferon binding Binding to type II interferon, also known as interferon-gamma. go.json IFN-gamma binding|IFNG binding|interferon-gamma binding http://purl.obolibrary.org/obo/GO_0019964 GO:0019965 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019965 GO:0019962 biolink:MolecularActivity type I interferon binding Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. go.json interferon-alpha binding|interferon-alpha/beta binding|interferon-beta binding|interferon-delta binding|interferon-epsilon binding|interferon-kappa binding|interferon-omega binding|interferon-tau binding|interferon-zeta binding|type I IFN binding http://purl.obolibrary.org/obo/GO_0019962 GO:0019963 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019963 GO:0019960 biolink:MolecularActivity C-X3-C chemokine binding Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. go.json http://purl.obolibrary.org/obo/GO_0019960 GO:0019961 biolink:MolecularActivity interferon binding Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. go.json IFN binding http://purl.obolibrary.org/obo/GO_0019961 GO:0019939 biolink:BiologicalProcess peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically. RESID:AA0308 go.json peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0019939 gocheck_do_not_annotate GO:0019937 biolink:BiologicalProcess obsolete protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic OBSOLETE. The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid. go.json True http://purl.obolibrary.org/obo/GO_0019937 GO:0019938 biolink:BiologicalProcess obsolete peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic OBSOLETE. The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions. go.json True http://purl.obolibrary.org/obo/GO_0019938 GO:0019935 biolink:BiologicalProcess cyclic-nucleotide-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. go.json cyclic-nucleotide-mediated signalling http://purl.obolibrary.org/obo/GO_0019935 GO:0019936 biolink:BiologicalProcess obsolete inositol phospholipid-mediated signaling OBSOLETE. (Was not defined before being made obsolete). go.json inositol phospholipid-mediated signaling|inositol phospholipid-mediated signalling True http://purl.obolibrary.org/obo/GO_0019936 GO:0019933 biolink:BiologicalProcess cAMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. go.json 3',5' cAMP-mediated signaling|3',5' cAMP-mediated signalling|3',5'-cAMP-mediated signaling|3',5'-cAMP-mediated signalling|adenosine 3',5'-cyclophosphate-mediated signaling|adenosine 3',5'-cyclophosphate-mediated signalling|cAMP signaling|cAMP signalling|cAMP-mediated signal transduction|cAMP-mediated signalling|cyclic AMP-mediated signaling|cyclic AMP-mediated signalling http://purl.obolibrary.org/obo/GO_0019933 GO:0019934 biolink:BiologicalProcess cGMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell. go.json cGMP-mediated signalling http://purl.obolibrary.org/obo/GO_0019934 GO:0019931 biolink:BiologicalProcess obsolete protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine OBSOLETE. The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine. RESID:AA0312 go.json True http://purl.obolibrary.org/obo/GO_0019931 GO:0019932 biolink:BiologicalProcess second-messenger-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. go.json second messenger mediated signaling|second messenger mediated signalling|second messenger-mediated signaling|second messenger-mediated signalling|second-messenger-mediated signal transduction|second-messenger-mediated signalling http://purl.obolibrary.org/obo/GO_0019932 GO:0019930 biolink:BiologicalProcess cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1. RESID:AA0316 go.json cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid|cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid|cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid http://purl.obolibrary.org/obo/GO_0019930 gocheck_do_not_annotate GO:0005307 biolink:MolecularActivity choline:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). go.json sodium/choline symporter activity http://purl.obolibrary.org/obo/GO_0005307 GO:0005308 biolink:MolecularActivity creatine transmembrane transporter activity Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. go.json http://purl.obolibrary.org/obo/GO_0005308 GO:0005306 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005306 GO:0005304 biolink:MolecularActivity L-valine transmembrane transporter activity Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid. go.json L-valine transporter activity|isoleucine/valine:sodium symporter activity|leucine/isoleucine/valine porter activity|leucine/valine/isoleucine permease activity|valine/tyrosine/tryptophan permease activity http://purl.obolibrary.org/obo/GO_0005304 GO:0005301 biolink:MolecularActivity obsolete valine/tyrosine/tryptophan permease activity OBSOLETE. (Was not defined before being made obsolete). go.json hydrogen/valine-tyrosine-tryptophan transporter|valine/tyrosine/tryptophan permease activity True http://purl.obolibrary.org/obo/GO_0005301 GO:0005302 biolink:MolecularActivity L-tyrosine transmembrane transporter activity Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid. go.json L-tyrosine permease activity|L-tyrosine transporter activity|valine/tyrosine/tryptophan permease activity http://purl.obolibrary.org/obo/GO_0005302 GO:0005300 biolink:MolecularActivity high-affinity tryptophan transmembrane transporter activity Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high-affinity tryptophan transporter activity http://purl.obolibrary.org/obo/GO_0005300 GO:0019948 biolink:MolecularActivity SUMO activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. Reactome:R-HSA-2990833|Reactome:R-HSA-2993781|Reactome:R-HSA-2993784 go.json SMT3 activating enzyme|SUMO E1 activator enzyme http://purl.obolibrary.org/obo/GO_0019948 GO:0019949 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019949 GO:0019946 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019946 GO:0019947 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019947 GO:0019944 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019944 GO:0019945 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019945 GO:0019942 biolink:BiologicalProcess obsolete NEDD8 class-dependent protein catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein. go.json NEDD8 class-dependent protein breakdown|NEDD8 class-dependent protein catabolic process|NEDD8 class-dependent protein catabolism|NEDD8 class-dependent protein degradation|RUB1-dependent protein catabolic process|RUB1-dependent protein catabolism|RUB1-dependent protein degradation True http://purl.obolibrary.org/obo/GO_0019942 GO:0019943 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019943 GO:0019940 biolink:BiologicalProcess obsolete SUMO-dependent protein catabolic process OBSOLETE. (Was not defined before being made obsolete). go.json SUMO-dependent protein breakdown|SUMO-dependent protein catabolic process|SUMO-dependent protein catabolism|SUMO-dependent protein degradation True http://purl.obolibrary.org/obo/GO_0019940 GO:0019941 biolink:BiologicalProcess modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. go.json modification-dependent protein breakdown|modification-dependent protein catabolism|modification-dependent protein degradation|modification-dependent proteolysis|modification-initiated protein catabolic process|modification-initiated protein catabolism|modification-initiated proteolysis|protein degradation tagging activity|protein-ligand-dependent protein catabolic process|protein-ligand-dependent protein catabolism http://purl.obolibrary.org/obo/GO_0019941 GO:0005309 biolink:MolecularActivity creatine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). Reactome:R-HSA-200396 go.json sodium/chloride-dependent creatine transporter http://purl.obolibrary.org/obo/GO_0005309 GO:0019919 biolink:BiologicalProcess peptidyl-arginine methylation, to asymmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. RESID:AA0068|RESID:AA0069 go.json peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine http://purl.obolibrary.org/obo/GO_0019919 gocheck_do_not_annotate GO:0019917 biolink:BiologicalProcess peptidyl-D-alanine racemization via peptidyl-L-serine The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine. RESID:AA0191 go.json http://purl.obolibrary.org/obo/GO_0019917 gocheck_do_not_annotate GO:0019918 biolink:BiologicalProcess peptidyl-arginine methylation, to symmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine. RESID:AA0067|RESID:AA0069 go.json http://purl.obolibrary.org/obo/GO_0019918 gocheck_do_not_annotate GO:0019915 biolink:BiologicalProcess lipid storage The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. go.json lipid retention|lipid sequestering|lipid sequestration|retention of lipids|sequestering of lipids|sequestration of lipid|sequestration of lipids|storage of lipids http://purl.obolibrary.org/obo/GO_0019915 GO:0019916 biolink:BiologicalProcess peptidyl-D-alanine racemization, direct The racemization of peptidyl-alanine. RESID:AA0191 go.json http://purl.obolibrary.org/obo/GO_0019916 gocheck_do_not_annotate GO:0019913 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019913 GO:0019914 biolink:MolecularActivity cyclin-dependent protein kinase activating kinase regulator activity Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase. go.json cyclin-dependent protein kinase activating kinase, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0019914 GO:0019911 biolink:MolecularActivity structural constituent of myelin sheath The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. go.json http://purl.obolibrary.org/obo/GO_0019911 GO:0019912 biolink:MolecularActivity cyclin-dependent protein kinase activating kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). go.json CAK|cdk-activating kinase activity|cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity http://purl.obolibrary.org/obo/GO_0019912 GO:0019910 biolink:CellularComponent mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0019910 GO:0019928 biolink:BiologicalProcess peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid. RESID:AA0314 go.json http://purl.obolibrary.org/obo/GO_0019928 gocheck_do_not_annotate GO:0019929 biolink:BiologicalProcess peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid. RESID:AA0315 go.json http://purl.obolibrary.org/obo/GO_0019929 gocheck_do_not_annotate GO:0019926 biolink:BiologicalProcess peptidyl-tryptophan oxidation to tryptophyl quinone The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine. go.json http://purl.obolibrary.org/obo/GO_0019926 gocheck_do_not_annotate GO:0019927 biolink:BiologicalProcess peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase. RESID:AA0313 go.json http://purl.obolibrary.org/obo/GO_0019927 gocheck_do_not_annotate GO:0019924 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019924 GO:0019925 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019925 GO:0019922 biolink:BiologicalProcess obsolete protein-chromophore linkage via peptidyl-cysteine OBSOLETE. The covalent linking of a chromophore to a protein via peptidyl-cysteines. go.json True http://purl.obolibrary.org/obo/GO_0019922 GO:0019923 biolink:BiologicalProcess obsolete alpha-1-microglobulin-chromophore linkage OBSOLETE. The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds. RESID:AA0224 go.json True http://purl.obolibrary.org/obo/GO_0019923 GO:0019920 biolink:BiologicalProcess peptidyl-1-thioglycine biosynthetic process, internal The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide. RESID:AA0265 go.json peptidyl-1-thioglycine anabolism, internal|peptidyl-1-thioglycine formation, internal|peptidyl-1-thioglycine synthesis, internal http://purl.obolibrary.org/obo/GO_0019920 gocheck_do_not_annotate GO:0019921 biolink:BiologicalProcess peptidyl-1-thioglycine biosynthetic process, carboxy-terminal The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond. RESID:AA0265 go.json peptidyl-1-thioglycine anabolism, carboxy-terminal|peptidyl-1-thioglycine formation, carboxy-terminal|peptidyl-1-thioglycine synthesis, carboxy-terminal http://purl.obolibrary.org/obo/GO_0019921 gocheck_do_not_annotate GO:0030499 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030499 GO:0030490 biolink:BiologicalProcess maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. go.json SSU-rRNA maturation|processing of 20S pre-rRNA http://purl.obolibrary.org/obo/GO_0030490 GO:0030497 biolink:BiologicalProcess fatty acid elongation The elongation of a fatty acid chain by the sequential addition of two-carbon units. go.json http://purl.obolibrary.org/obo/GO_0030497 GO:0030498 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030498 GO:0030495 biolink:BiologicalProcess bacteriochlorophyll catabolic process The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. go.json bacteriochlorophyll breakdown|bacteriochlorophyll catabolism|bacteriochlorophyll degradation http://purl.obolibrary.org/obo/GO_0030495 GO:0030496 biolink:CellularComponent midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. Wikipedia:Midbody_(cell_biology) go.json http://purl.obolibrary.org/obo/GO_0030496 goslim_pir GO:0030493 biolink:BiologicalProcess bacteriochlorophyll metabolic process The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. go.json bacteriochlorophyll metabolism http://purl.obolibrary.org/obo/GO_0030493 GO:0030494 biolink:BiologicalProcess bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. go.json bacteriochlorophyll anabolism|bacteriochlorophyll biosynthesis|bacteriochlorophyll formation|bacteriochlorophyll synthesis http://purl.obolibrary.org/obo/GO_0030494 GO:0030491 biolink:BiologicalProcess heteroduplex formation The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. go.json http://purl.obolibrary.org/obo/GO_0030491 GO:0030492 biolink:MolecularActivity hemoglobin binding Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. go.json globin binding|haemoglobin binding http://purl.obolibrary.org/obo/GO_0030492 GO:0030488 biolink:BiologicalProcess tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0030488 GO:0030489 biolink:BiologicalProcess obsolete processing of 27S pre-rRNA OBSOLETE. (Was not defined before being made obsolete). go.json processing of 27S pre-rRNA True http://purl.obolibrary.org/obo/GO_0030489 GO:0030486 biolink:CellularComponent smooth muscle dense body Electron-dense region associated with a smooth muscle contractile fiber. go.json http://purl.obolibrary.org/obo/GO_0030486 GO:0030487 biolink:MolecularActivity inositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0030487 GO:0030484 biolink:CellularComponent obsolete muscle fiber OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. go.json muscle fiber|muscle fibre True http://purl.obolibrary.org/obo/GO_0030484 GO:0030485 biolink:CellularComponent smooth muscle contractile fiber The contractile fiber of smooth muscle cells. go.json http://purl.obolibrary.org/obo/GO_0030485 GO:0030482 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030482 GO:0030483 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030483 GO:0030480 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030480 GO:0030481 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030481 GO:0030479 biolink:CellularComponent actin cortical patch An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. go.json actin patch http://purl.obolibrary.org/obo/GO_0030479 GO:0030477 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030477 GO:0030478 biolink:CellularComponent actin cap Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0030478 GO:0030475 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030475 GO:0030476 biolink:BiologicalProcess ascospore wall assembly The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae. go.json spore wall assembly http://purl.obolibrary.org/obo/GO_0030476 GO:0030473 biolink:BiologicalProcess nuclear migration along microtubule The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. go.json microtubule cytoskeleton-dependent nuclear positioning|microtubule cytoskeleton-dependent nucleus positioning|microtubule-dependent nuclear positioning|microtubule-dependent nucleus positioning|microtubule-mediated nuclear migration|nuclear migration, microtubule-mediated|nuclear movement, microtubule-mediated|nucleus migration|transport of nucleus by microtubules|transport of nucleus, microtubule-mediated http://purl.obolibrary.org/obo/GO_0030473 GO:0030474 biolink:BiologicalProcess spindle pole body duplication Construction of a new spindle pole body. go.json spindle pole body assembly|spindle pole body biogenesis|spindle pole body biosynthesis|spindle pole body duplication associated with nuclear envelope|spindle pole body duplication in cytoplasm|spindle pole body formation|spindle pole body replication http://purl.obolibrary.org/obo/GO_0030474 GO:0030471 biolink:BiologicalProcess obsolete spindle pole body and microtubule cycle (sensu Fungi) OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). go.json spindle pole body and microtubule cycle (sensu Fungi)|spindle pole body and microtubule cycle (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0030471 GO:0030472 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030472 GO:0030470 biolink:BiologicalProcess obsolete spore germination (sensu Fungi) OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). go.json germination (sensu Saccharomyces)|spore germination (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030470 GO:0030468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030468 GO:0030469 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030469 GO:0030466 biolink:BiologicalProcess silent mating-type cassette heterochromatin formation Repression of transcription at silent mating-type loci by alteration of the structure of chromatin. go.json aging-dependent sterility|chromatin silencing at HML and HMR|chromatin silencing at silent mating-type cassette|establishment of chromatin silencing at silent mating-type cassette|heterochromatic silencing at silent mating-type cassette|silent mating-type cassette chromatin silencing|silent mating-type cassette heterochromatin assembly http://purl.obolibrary.org/obo/GO_0030466 GO:0030467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030467 GO:0030464 biolink:BiologicalProcess obsolete aging dependent sterility (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json aging dependent sterility (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030464 GO:0030465 biolink:BiologicalProcess obsolete autophagic death (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json autophagic death (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030465 GO:0030462 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030462 GO:0030463 biolink:BiologicalProcess obsolete cell aging (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json cell aging (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030463 GO:0030460 biolink:BiologicalProcess obsolete nuclear translocation of MAPK (mating sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json nuclear translocation of MAPK (mating sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030460 GO:0030461 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030461 GO:0030459 biolink:BiologicalProcess obsolete inactivation of MAPK (mating sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json inactivation of MAPK (mating sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030459 GO:0030457 biolink:BiologicalProcess obsolete activation of MAPKK (mating sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json activation of MAPKK (mating sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030457 GO:0030458 biolink:BiologicalProcess obsolete activation of MAPKKK (mating sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json activation of MAPKKK (mating sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030458 GO:0030455 biolink:BiologicalProcess obsolete MAPKKK cascade (mating sensu Fungi) OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus. go.json MAPKKK cascade (mating sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030455 GO:0005499 biolink:MolecularActivity vitamin D binding Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json calciferol binding|cholecalciferol binding|ergocalciferol binding http://purl.obolibrary.org/obo/GO_0005499 GO:0030456 biolink:BiologicalProcess obsolete activation of MAPK (mating sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json activation of MAPK (mating sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030456 GO:0005497 biolink:MolecularActivity androgen binding Binding to an androgen, a male sex hormone. go.json http://purl.obolibrary.org/obo/GO_0005497 GO:0005498 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005498 GO:0005496 biolink:MolecularActivity steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. go.json http://purl.obolibrary.org/obo/GO_0005496 goslim_pir GO:0030453 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030453 GO:0030454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030454 GO:0030451 biolink:BiologicalProcess regulation of complement activation, alternative pathway Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation. go.json regulation of complement cascade, alternative pathway http://purl.obolibrary.org/obo/GO_0030451 GO:0030452 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030452 GO:0030450 biolink:BiologicalProcess regulation of complement activation, classical pathway Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. go.json regulation of complement cascade, classical pathway http://purl.obolibrary.org/obo/GO_0030450 GO:0030448 biolink:BiologicalProcess hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls. go.json formation of symbiont invasive hypha in host|formation of symbiont invasive hypha within host|formation of symbiont invasive hypha within host during symbiotic interaction|invasive hyphal growth|symbiont invasive hypha formation within host http://purl.obolibrary.org/obo/GO_0030448 goslim_candida GO:0030449 biolink:BiologicalProcess regulation of complement activation Any process that modulates the frequency, rate or extent of complement activation. go.json regulation of complement cascade http://purl.obolibrary.org/obo/GO_0030449 GO:0030446 biolink:CellularComponent hyphal cell wall The cell wall surrounding a fungal hypha. go.json http://purl.obolibrary.org/obo/GO_0030446 GO:0030447 biolink:BiologicalProcess filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0030447 goslim_candida GO:0030444 biolink:BiologicalProcess obsolete microtubule depolymerization during nuclear congression OBSOLETE. (Was not defined before being made obsolete). go.json microtubule depolymerization during nuclear congression True http://purl.obolibrary.org/obo/GO_0030444 GO:0030445 biolink:CellularComponent yeast-form cell wall The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form. go.json http://purl.obolibrary.org/obo/GO_0030445 GO:0030442 biolink:BiologicalProcess obsolete inactivation of MAPK during sporulation (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json inactivation of MAPK during sporulation (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030442 GO:0030443 biolink:BiologicalProcess obsolete nuclear translocation of MAPK during sporulation (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json nuclear translocation of MAPK during sporulation (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030443 GO:0030440 biolink:BiologicalProcess obsolete activation of MAPKK during sporulation (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json activation of MAPKK during sporulation (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030440 GO:0030441 biolink:BiologicalProcess obsolete activation of MAPKKK during sporulation (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json activation of MAPKKK during sporulation (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030441 GO:0030439 biolink:BiologicalProcess obsolete activation of MAPK during sporulation (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json activation of MAPK during sporulation (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030439 GO:0030437 biolink:BiologicalProcess ascospore formation The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota). go.json ascospore biosynthesis|spore formation|sporulation http://purl.obolibrary.org/obo/GO_0030437 goslim_pombe GO:0030438 biolink:BiologicalProcess obsolete MAPKKK cascade during sporulation (sensu Fungi) OBSOLETE. (Was not defined before being made obsolete). go.json MAPKKK cascade during sporulation (sensu Fungi) True http://purl.obolibrary.org/obo/GO_0030438 GO:0030435 biolink:BiologicalProcess sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. Wikipedia:Sporogenesis go.json cellular spore formation by sporulation|spore biosynthesis|spore differentiation|spore formation http://purl.obolibrary.org/obo/GO_0030435 GO:0005479 biolink:MolecularActivity obsolete vacuolar assembly OBSOLETE. (Was not defined before being made obsolete). go.json vacuolar assembly True http://purl.obolibrary.org/obo/GO_0005479 GO:0030436 biolink:BiologicalProcess asexual sporulation The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi. go.json asexual reproductive sporulation|asexual spore formation|mitotic spore formation|mitotic sporulation http://purl.obolibrary.org/obo/GO_0030436 GO:0030433 biolink:BiologicalProcess ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. go.json ER-associated ubiquitin-dependent protein breakdown|ER-associated ubiquitin-dependent protein catabolic process|ER-associated ubiquitin-dependent protein catabolism|ER-associated ubiquitin-dependent protein degradation|ERAD|endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process|endoplasmic reticulum-associated ubiqutin-dependent protein catabolism|ubiquitin-dependent proteasomal protein catabolism of ER proteins http://purl.obolibrary.org/obo/GO_0030433 GO:0005477 biolink:MolecularActivity pyruvate secondary active transmembrane transporter activity Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json pyruvate carrier activity http://purl.obolibrary.org/obo/GO_0005477 GO:0030434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030434 GO:0005478 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005478 GO:0005476 biolink:MolecularActivity carnitine:acyl carnitine antiporter activity Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial). go.json carnitine/acyl carnitine carrier activity|carnitine:acyl carnitine carrier activity|fatty acyl carnitine carrier http://purl.obolibrary.org/obo/GO_0005476 GO:0005471 biolink:MolecularActivity ATP:ADP antiporter activity Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). go.json ADP/ATP carrier protein|ADP/ATP translocase|ATP/ADP exchange|ATP/ADP exchanger|adenine nucleotide translocase http://purl.obolibrary.org/obo/GO_0005471 GO:0005472 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005472 GO:0030431 biolink:BiologicalProcess sleep Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. Wikipedia:Sleep go.json diapause|dormancy|lethargus http://purl.obolibrary.org/obo/GO_0030431 goslim_pir GO:0030432 biolink:BiologicalProcess peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. Wikipedia:Peristalsis go.json http://purl.obolibrary.org/obo/GO_0030432 GO:0030430 biolink:CellularComponent host cell cytoplasm The cytoplasm of a host cell. go.json other organism cytoplasm http://purl.obolibrary.org/obo/GO_0030430 GO:0030428 biolink:CellularComponent cell septum A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. go.json cross wall|septum http://purl.obolibrary.org/obo/GO_0030428 goslim_pir GO:0030429 biolink:MolecularActivity kynureninase activity Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. EC:3.7.1.3|MetaCyc:KYNURENINASE-RXN|RHEA:16813|Reactome:R-HSA-71217 go.json L-kynurenine hydrolase activity|kynurenine hydrolase activity http://purl.obolibrary.org/obo/GO_0030429 GO:0030426 biolink:CellularComponent growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. Wikipedia:Growth_cone go.json http://purl.obolibrary.org/obo/GO_0030426 GO:0030427 biolink:CellularComponent site of polarized growth Any part of a cell where non-isotropic growth takes place. go.json http://purl.obolibrary.org/obo/GO_0030427 goslim_candida|goslim_pir|goslim_yeast GO:0030424 biolink:CellularComponent axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. NIF_Subcellular:sao1770195789|Wikipedia:Axon go.json http://purl.obolibrary.org/obo/GO_0030424 GO:0030425 biolink:CellularComponent dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. NIF_Subcellular:sao1211023249|Wikipedia:Dendrite go.json http://purl.obolibrary.org/obo/GO_0030425 GO:0030422 biolink:BiologicalProcess siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase. go.json RNA interference, production of guide RNAs|RNA interference, production of siRNA|chromatin silencing by small RNA, production of guide RNAs|chromatin silencing by small RNA, production of siRNA|production of guide RNAs involved in RNA interference|production of guide RNAs involved in chromatin silencing by small RNA|production of siRNA|production of siRNA involved in PTGS|production of siRNA involved in RNA interference|production of siRNA involved in chromatin silencing by small RNA|production of siRNA involved in gene silencing by small RNA|production of siRNA involved in post-transcriptional gene silencing by RNA http://purl.obolibrary.org/obo/GO_0030422 GO:0005488 biolink:MolecularActivity binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. Wikipedia:Binding_(molecular) go.json ligand http://purl.obolibrary.org/obo/GO_0005488 gocheck_do_not_annotate|goslim_pir|goslim_plant GO:0005489 biolink:MolecularActivity obsolete electron transporter activity OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells. go.json Rieske iron-sulfur protein|class I cytochrome c|class II cytochrome c|class III cytochrome c|class IIa cytochrome c|class IIb cytochrome c|class IV cytochrome c|cytochrome b|cytochrome b5|cytochrome c3 (tetraheme)|cytochrome c554|cytochrome c7 (triheme)|cytochrome d|diheme class I cytochrome c|electron transfer carrier|electron transporter activity|flavin-containing electron transporter|flavodoxin|high-molecular-weight cytochrome c (hexadecaheme)|monoheme class I cytochrome c|nonaheme cytochrome c|respiratory chain cytochrome b6 True http://purl.obolibrary.org/obo/GO_0005489 GO:0030423 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030423 GO:0005486 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005486 GO:0005487 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005487 GO:0005484 biolink:MolecularActivity SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. go.json Q-SNARE activity|R-SNARE activity|SNAP-25|SNARE|t-SNARE activity|v-SNARE activity http://purl.obolibrary.org/obo/GO_0005484 goslim_chembl GO:0005485 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005485 GO:0005482 biolink:MolecularActivity obsolete vesicle targeting OBSOLETE. (Was not defined before being made obsolete). go.json vesicle targeting True http://purl.obolibrary.org/obo/GO_0005482 GO:0005483 biolink:MolecularActivity soluble NSF attachment protein activity Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex. go.json SNAP http://purl.obolibrary.org/obo/GO_0005483 GO:0005480 biolink:MolecularActivity obsolete vesicle transport OBSOLETE. (Was not defined before being made obsolete). go.json vesicle transport True http://purl.obolibrary.org/obo/GO_0005480 GO:0005481 biolink:MolecularActivity obsolete vesicle fusion OBSOLETE. (Was not defined before being made obsolete). go.json vesicle fusion True http://purl.obolibrary.org/obo/GO_0005481 GO:0005490 biolink:MolecularActivity obsolete cytochrome P450 OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates. go.json cytochrome P450 True http://purl.obolibrary.org/obo/GO_0005490 GO:0030420 biolink:BiologicalProcess establishment of competence for transformation The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. go.json http://purl.obolibrary.org/obo/GO_0030420 GO:0030421 biolink:BiologicalProcess defecation The expulsion of feces from the rectum. Wikipedia:Defecation go.json http://purl.obolibrary.org/obo/GO_0030421 RO:0002427 biolink:OntologyClass causally downstream of or within RO:0002427 go.json http://purl.obolibrary.org/obo/RO_0002427 RO:0002418 biolink:OntologyClass causally upstream of or within RO:0002418 go.json http://purl.obolibrary.org/obo/RO_0002418 RO:0002411 biolink:OntologyClass causally upstream of RO:0002411 go.json http://purl.obolibrary.org/obo/RO_0002411 RO:0002412 biolink:OntologyClass immediately causally upstream of RO:0002412 go.json http://purl.obolibrary.org/obo/RO_0002412 RO:0002404 biolink:OntologyClass causally downstream of RO:0002404 go.json http://purl.obolibrary.org/obo/RO_0002404 RO:0002405 biolink:OntologyClass immediately causally downstream of RO:0002405 go.json http://purl.obolibrary.org/obo/RO_0002405 GO:0030417 biolink:BiologicalProcess nicotianamine metabolic process The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. go.json nicotianamine metabolism http://purl.obolibrary.org/obo/GO_0030417 GO:0030418 biolink:BiologicalProcess nicotianamine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. go.json nicotianamine anabolism|nicotianamine biosynthesis|nicotianamine formation|nicotianamine synthesis http://purl.obolibrary.org/obo/GO_0030418 GO:0030415 biolink:MolecularActivity obsolete carboxypeptidase A inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A. go.json carboxypeptidase A inhibitor activity True http://purl.obolibrary.org/obo/GO_0030415 GO:0005459 biolink:MolecularActivity UDP-galactose transmembrane transporter activity Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. Reactome:R-HSA-5652099|Reactome:R-HSA-735702 go.json http://purl.obolibrary.org/obo/GO_0005459 GO:0030416 biolink:BiologicalProcess methylamine metabolic process The chemical reactions and pathways involving methylamine (CH3NH2). go.json methylamine metabolism|methylammonium metabolic process|methylammonium metabolism http://purl.obolibrary.org/obo/GO_0030416 GO:0030413 biolink:MolecularActivity competence pheromone activity A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence. go.json http://purl.obolibrary.org/obo/GO_0030413 GO:0005457 biolink:MolecularActivity GDP-fucose transmembrane transporter activity Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. Reactome:R-HSA-5653596|Reactome:R-HSA-742345 go.json http://purl.obolibrary.org/obo/GO_0005457 GO:0005458 biolink:MolecularActivity GDP-mannose transmembrane transporter activity Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate. go.json http://purl.obolibrary.org/obo/GO_0005458 GO:0030414 biolink:MolecularActivity peptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. go.json protease inhibitor activity http://purl.obolibrary.org/obo/GO_0030414 GO:0030411 biolink:MolecularActivity scytalone dehydratase activity Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O. EC:4.2.1.94|KEGG_REACTION:R02907|MetaCyc:SCYTALONE-DEHYDRATASE-RXN|RHEA:24396 go.json scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)|scytalone 7,8-hydro-lyase activity http://purl.obolibrary.org/obo/GO_0030411 GO:0030412 biolink:MolecularActivity formimidoyltetrahydrofolate cyclodeaminase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4. EC:4.3.1.4|KEGG_REACTION:R02302|MetaCyc:4.3.1.4-RXN|RHEA:22736|Reactome:R-HSA-70920 go.json 5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)|5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)|formiminotetrahydrofolate cyclodeaminase activity http://purl.obolibrary.org/obo/GO_0030412 GO:0005456 biolink:MolecularActivity CMP-N-acetylneuraminate transmembrane transporter activity Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other. Reactome:R-HSA-5651942|Reactome:R-HSA-727807 go.json CMP-sialic acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005456 GO:0005453 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005453 GO:0005454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005454 GO:0005451 biolink:MolecularActivity obsolete monoatomic cation:proton antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + H+(in) = monoatomic cation(in) + H+(out). go.json monovalent cation:hydrogen antiporter activity|monovalent cation:proton antiporter activity True http://purl.obolibrary.org/obo/GO_0005451 GO:0005452 biolink:MolecularActivity solute:inorganic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). Reactome:R-HSA-1237038|Reactome:R-HSA-1247665|Reactome:R-HSA-425482|Reactome:R-HSA-425577|Reactome:R-HSA-427666|Reactome:R-HSA-5627737|Reactome:R-HSA-5656248 go.json inorganic anion exchanger activity http://purl.obolibrary.org/obo/GO_0005452 GO:0030419 biolink:BiologicalProcess nicotianamine catabolic process The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. go.json nicotianamine breakdown|nicotianamine catabolism|nicotianamine degradation http://purl.obolibrary.org/obo/GO_0030419 GO:0030410 biolink:MolecularActivity nicotianamine synthase activity Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine. EC:2.5.1.43|KEGG_REACTION:R00075|MetaCyc:2.5.1.43-RXN|RHEA:16481 go.json S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity http://purl.obolibrary.org/obo/GO_0030410 GO:0030406 biolink:MolecularActivity obsolete matrix metalloproteinase 25 activity OBSOLETE. Was not defined before being made obsolete. go.json MMP-25|MT6-MMP|matrix metalloproteinase 25 activity True http://purl.obolibrary.org/obo/GO_0030406 GO:0030407 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030407 GO:0030404 biolink:MolecularActivity obsolete collagenase 3 activity OBSOLETE. Was not defined before being made obsolete. go.json MMP-13|collagenase 3 activity|matrix metalloproteinase 13 True http://purl.obolibrary.org/obo/GO_0030404 GO:0030405 biolink:MolecularActivity obsolete matrix metalloproteinase 19 activity OBSOLETE. Was not defined before being made obsolete. go.json MMP-19|matrix metalloproteinase 19 activity True http://purl.obolibrary.org/obo/GO_0030405 GO:0005468 biolink:MolecularActivity obsolete small-molecule carrier or transporter OBSOLETE. (Was not defined before being made obsolete). go.json small-molecule carrier or transporter True http://purl.obolibrary.org/obo/GO_0005468 GO:0030402 biolink:MolecularActivity obsolete matrilysin-2 activity OBSOLETE. Was not defined before being made obsolete. go.json MMP-26|matrilysin-2 activity|matrix metalloproteinase 26 True http://purl.obolibrary.org/obo/GO_0030402 GO:0030403 biolink:MolecularActivity obsolete collagenase 4 activity OBSOLETE. Was not defined before being made obsolete. go.json MMP-18|collagenase 4 activity|matrix metalloproteinase 18 True http://purl.obolibrary.org/obo/GO_0030403 GO:0005469 biolink:MolecularActivity succinate:fumarate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out). go.json http://purl.obolibrary.org/obo/GO_0005469 GO:0030400 biolink:MolecularActivity obsolete protease substrate recruitment factor activity OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity. go.json protease substrate recruitment factor activity True http://purl.obolibrary.org/obo/GO_0030400 GO:0030401 biolink:MolecularActivity obsolete transcription antiterminator activity OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed. go.json transcription antiterminator activity|transcriptional antiterminator activity True http://purl.obolibrary.org/obo/GO_0030401 GO:0005464 biolink:MolecularActivity UDP-xylose transmembrane transporter activity Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. Reactome:R-HSA-742373 go.json http://purl.obolibrary.org/obo/GO_0005464 GO:0005462 biolink:MolecularActivity UDP-N-acetylglucosamine transmembrane transporter activity Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. Reactome:R-HSA-5653622|Reactome:R-HSA-741450|Reactome:R-HSA-742354 go.json http://purl.obolibrary.org/obo/GO_0005462 GO:0005463 biolink:MolecularActivity UDP-N-acetylgalactosamine transmembrane transporter activity Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. go.json http://purl.obolibrary.org/obo/GO_0005463 GO:0005460 biolink:MolecularActivity UDP-glucose transmembrane transporter activity Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. go.json http://purl.obolibrary.org/obo/GO_0005460 GO:0005461 biolink:MolecularActivity UDP-glucuronic acid transmembrane transporter activity Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. Reactome:R-HSA-174368|Reactome:R-HSA-5603297 go.json http://purl.obolibrary.org/obo/GO_0005461 GO:0030408 biolink:MolecularActivity glycine formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine. EC:2.1.2.4|KEGG_REACTION:R02729|MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN|RHEA:24288 go.json 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity|FIG formiminotransferase activity|formimidoyltransferase activity|formiminoglycine formiminotransferase activity|formiminotransferase activity|glycine formiminotransferase activity http://purl.obolibrary.org/obo/GO_0030408 GO:0030409 biolink:MolecularActivity glutamate formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. EC:2.1.2.5|MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN|RHEA:15097 go.json 5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity|formimidoyltransferase activity|formiminoglutamic acid transferase activity|formiminoglutamic formiminotransferase activity|formiminotransferase activity|glutamate formiminotransferase activity|glutamate formyltransferase activity http://purl.obolibrary.org/obo/GO_0030409 GO:0005436 biolink:MolecularActivity sodium:phosphate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). Reactome:R-HSA-2872498|Reactome:R-HSA-427605|Reactome:R-HSA-427645|Reactome:R-HSA-427656|Reactome:R-HSA-428609|Reactome:R-HSA-5625123|Reactome:R-HSA-5651685|Reactome:R-HSA-5651697|Reactome:R-HSA-5651971|Reactome:R-HSA-5687585 go.json sodium-dependent phosphate transmembrane transporter activity|sodium/phosphate symporter activity http://purl.obolibrary.org/obo/GO_0005436 GO:0005432 biolink:MolecularActivity calcium:sodium antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). RHEA:29255|Reactome:R-HSA-425661|Reactome:R-HSA-8949688|Reactome:R-HSA-8949703 go.json mitochondrial sodium/calcium ion exchange|sodium/calcium exchanger|sodium:calcium exchange http://purl.obolibrary.org/obo/GO_0005432 GO:0005430 biolink:MolecularActivity obsolete synaptic vesicle amine transmembrane transporter activity OBSOLETE. Enables the transfer of amines across synaptic vesicle membranes. go.json True http://purl.obolibrary.org/obo/GO_0005430 GO:0005415 biolink:MolecularActivity nucleoside:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). Reactome:R-HSA-109530|Reactome:R-HSA-109538|Reactome:R-HSA-109539|Reactome:R-HSA-9751037|Reactome:R-HSA-9754934 go.json nucleoside-sodium cotransporter activity|sodium-dependent nucleoside transporter activity http://purl.obolibrary.org/obo/GO_0005415 GO:0005416 biolink:MolecularActivity amino acid:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). go.json amino acid:cation symporter activity|cation/amino acid symporter activity|cation:amino acid symporter activity http://purl.obolibrary.org/obo/GO_0005416 GO:0005412 biolink:MolecularActivity glucose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). Reactome:R-HSA-189208|Reactome:R-HSA-429613|Reactome:R-HSA-5656356|Reactome:R-HSA-5658163|Reactome:R-HSA-8932955 go.json sodium/glucose symporter activity http://purl.obolibrary.org/obo/GO_0005412 GO:0005429 biolink:MolecularActivity obsolete chromaffin granule amine transmembrane transporter activity OBSOLETE. Enables the transfer of amines across chromaffin granule membranes. go.json True http://purl.obolibrary.org/obo/GO_0005429 GO:0005427 biolink:MolecularActivity proton-dependent oligopeptide secondary active transmembrane transporter activity Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. go.json hydrogen/oligopeptide symporter|proton-dependent oligopeptide transporter activity http://purl.obolibrary.org/obo/GO_0005427 GO:0005402 biolink:MolecularActivity carbohydrate:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). go.json carbohydrate:cation symporter activity|cation/sugar symporter activity|cation:sugar symporter activity|sugar:cation symporter activity http://purl.obolibrary.org/obo/GO_0005402 GO:0005403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005403 GO:0005400 biolink:MolecularActivity obsolete peroxisomal membrane transporter OBSOLETE. (Was not defined before being made obsolete). go.json peroxisomal membrane transporter True http://purl.obolibrary.org/obo/GO_0005400 GO:0030598 biolink:MolecularActivity rRNA N-glycosylase activity Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species. EC:3.2.2.22|MetaCyc:3.2.2.22-RXN go.json RNA N-glycosidase activity|gelonin|mirabilis antiviral protein|momorcochin-S|nigrin b|rRNA N-glycohydrolase activity|rRNA N-glycosidase activity|ribosomal ribonucleate N-glycosidase activity|ricin|saporins http://purl.obolibrary.org/obo/GO_0030598 GO:0030599 biolink:MolecularActivity pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate. EC:3.1.1.11|MetaCyc:RXN-19782|RHEA:22380 go.json pectase activity|pectin demethoxylase activity|pectin methoxylase activity|pectin methyl esterase activity|pectin methylesterase activity|pectin pectylhydrolase activity|pectinoesterase activity http://purl.obolibrary.org/obo/GO_0030599 GO:0030596 biolink:MolecularActivity alpha-L-rhamnosidase activity Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. EC:3.2.1.40|MetaCyc:3.2.1.40-RXN go.json alpha-L-rhamnosidase N|alpha-L-rhamnosidase T|alpha-L-rhamnoside rhamnohydrolase activity http://purl.obolibrary.org/obo/GO_0030596 GO:0030597 biolink:MolecularActivity RNA glycosylase activity Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0030597 GO:0030594 biolink:MolecularActivity neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0030594 GO:0030595 biolink:BiologicalProcess leukocyte chemotaxis The movement of a leukocyte in response to an external stimulus. go.json immune cell chemotaxis|leucocyte chemotaxis http://purl.obolibrary.org/obo/GO_0030595 GO:0030592 biolink:BiologicalProcess DNA ADP-ribosylation The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0030592 GO:0030593 biolink:BiologicalProcess neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. go.json http://purl.obolibrary.org/obo/GO_0030593 GO:0030590 biolink:BiologicalProcess first cell cycle pseudocleavage A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms. go.json http://purl.obolibrary.org/obo/GO_0030590 GO:0030591 biolink:MolecularActivity 2'-deoxyguanosine DNA ADP-ribosyltransferase activity Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form. go.json NAD DNA ADP-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0030591 GO:0030589 biolink:BiologicalProcess pseudocleavage involved in syncytial blastoderm formation Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster. go.json pseudocleavage during syncytial blastoderm formation http://purl.obolibrary.org/obo/GO_0030589 GO:0030587 biolink:BiologicalProcess sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum. go.json fruiting body development|fruiting body formation|sorocarp biosynthesis|sorocarp formation http://purl.obolibrary.org/obo/GO_0030587 GO:0030588 biolink:BiologicalProcess pseudocleavage Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0030588 GO:0030585 biolink:MolecularActivity phosphoenolpyruvate carboxykinase (diphosphate) activity Catalysis of the reaction: diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate. EC:4.1.1.38|KEGG_REACTION:R00346|MetaCyc:4.1.1.38-RXN|RHEA:22356 go.json PEP carboxyphosphotransferase activity|PEPCTrP|diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)|diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)|phosphoenolpyruvate carboxykinase (pyrophosphate) activity|phosphoenolpyruvate carboxylase (pyrophosphate)|phosphoenolpyruvate carboxyphosphotransferase activity|phosphoenolpyruvate carboxytransphosphorylase activity|phosphoenolpyruvic carboxykinase|phosphoenolpyruvic carboxykinase (pyrophosphate)|phosphoenolpyruvic carboxylase (pyrophosphate)|phosphoenolpyruvic carboxytransphosphorylase activity|phosphopyruvate carboxykinase|phosphopyruvate carboxykinase (pyrophosphate)|phosphopyruvate carboxylase (pyrophosphate) http://purl.obolibrary.org/obo/GO_0030585 GO:0030586 biolink:MolecularActivity [methionine synthase] reductase activity Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. EC:1.16.1.8|MetaCyc:2.1.1.135-RXN|RHEA:23908|Reactome:R-HSA-3149518 go.json 5-methyltetrahydrofolate-homocysteine methyltransferase reductase|[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity|methionine synthase cob(II)alamin reductase (methylating) activity|methionine synthase reductase activity|methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)|methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0030586 GO:0030583 biolink:BiologicalProcess myxococcal fruiting body development The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure. go.json fruiting body development in cellular response to starvation|fruiting body development in response to starvation http://purl.obolibrary.org/obo/GO_0030583 GO:0030584 biolink:BiologicalProcess sporocarp development The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea. go.json fruiting body development http://purl.obolibrary.org/obo/GO_0030584 GO:0030581 biolink:BiologicalProcess symbiont intracellular protein transport in host The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json host cell protein transport|intracellular protein transport in host|intracellular protein transport in other organism during symbiotic interaction|intracellular protein transport in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0030581 GO:0030582 biolink:BiologicalProcess reproductive fruiting body development The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores. go.json fruiting body formation http://purl.obolibrary.org/obo/GO_0030582 GO:0030580 biolink:MolecularActivity quinone cofactor methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1). go.json http://purl.obolibrary.org/obo/GO_0030580 GO:0030578 biolink:BiologicalProcess PML body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia). go.json PML body organisation|PML body organization and biogenesis http://purl.obolibrary.org/obo/GO_0030578 GO:0030579 biolink:BiologicalProcess obsolete ubiquitin-dependent SMAD protein catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome. go.json ubiquitin-dependent SMAD protein breakdown|ubiquitin-dependent SMAD protein catabolism|ubiquitin-dependent SMAD protein degradation True http://purl.obolibrary.org/obo/GO_0030579 GO:0030576 biolink:BiologicalProcess Cajal body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors. go.json Cajal body organisation|Cajal body organization and biogenesis http://purl.obolibrary.org/obo/GO_0030576 GO:0030577 biolink:BiologicalProcess Lands organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies. go.json LYSP100-associated nuclear domain organization|Lands organisation|Lands organization and biogenesis http://purl.obolibrary.org/obo/GO_0030577 GO:0030574 biolink:BiologicalProcess collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. go.json collagen breakdown|collagen catabolism|collagen degradation http://purl.obolibrary.org/obo/GO_0030574 GO:0030575 biolink:BiologicalProcess nuclear body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. go.json nuclear body organisation|nuclear body organization and biogenesis http://purl.obolibrary.org/obo/GO_0030575 GO:0030572 biolink:MolecularActivity phosphatidyltransferase activity Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group. go.json http://purl.obolibrary.org/obo/GO_0030572 GO:0030573 biolink:BiologicalProcess bile acid catabolic process The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. go.json bile acid 7alpha-dehydroxylation pathway|bile acid breakdown|bile acid catabolism|bile acid degradation|cholate catabolic process http://purl.obolibrary.org/obo/GO_0030573 GO:0030570 biolink:MolecularActivity pectate lyase activity Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. EC:4.2.2.2|MetaCyc:4.2.2.2-RXN go.json (1->4)-alpha-D-galacturonan lyase activity|PGA lyase activity|PPase-N activity|alpha-1,4-D-endopolygalacturonic acid lyase activity|endo-alpha-1,4-polygalacturonic acid lyase activity|endogalacturonate transeliminase activity|endopectin methyltranseliminase activity|pectate transeliminase activity|pectic acid lyase activity|pectic acid transeliminase activity|pectic lyase activity|pectin trans-eliminase activity|polygalacturonate lyase activity|polygalacturonic acid lyase activity|polygalacturonic acid trans-eliminase activity|polygalacturonic transeliminase activity http://purl.obolibrary.org/obo/GO_0030570 GO:0030571 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030571 GO:0030569 biolink:MolecularActivity obsolete chymotrypsin inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin. go.json chymotrypsin inhibitor activity True http://purl.obolibrary.org/obo/GO_0030569 GO:0030567 biolink:MolecularActivity obsolete thrombin activator activity OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin. go.json prothrombin activator activity|thrombin activator activity True http://purl.obolibrary.org/obo/GO_0030567 GO:0030568 biolink:MolecularActivity obsolete plasmin inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin. go.json plasmin inhibitor activity True http://purl.obolibrary.org/obo/GO_0030568 GO:0030565 biolink:MolecularActivity snRNA pseudouridylation guide activity Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0030565 GO:0030566 biolink:MolecularActivity snRNA modification guide activity Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030566 GO:0030563 biolink:MolecularActivity snRNA 2'-O-ribose methylation guide activity Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0030563 GO:0030564 biolink:MolecularActivity tRNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030564 GO:0030561 biolink:MolecularActivity RNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030561 GO:0030562 biolink:MolecularActivity rRNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030562 GO:0030560 biolink:MolecularActivity tRNA pseudouridylation guide activity Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030560 GO:0030558 biolink:MolecularActivity RNA pseudouridylation guide activity Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030558 GO:0030559 biolink:MolecularActivity rRNA pseudouridylation guide activity Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030559 GO:0030556 biolink:MolecularActivity rRNA modification guide activity Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030556 GO:0030557 biolink:MolecularActivity tRNA modification guide activity Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030557 GO:0030554 biolink:MolecularActivity adenyl nucleotide binding Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate. go.json http://purl.obolibrary.org/obo/GO_0030554 goslim_chembl GO:0005598 biolink:CellularComponent short-chain collagen trimer Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils. go.json http://purl.obolibrary.org/obo/GO_0005598 GO:0030555 biolink:MolecularActivity RNA modification guide activity Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue. go.json http://purl.obolibrary.org/obo/GO_0030555 goslim_yeast GO:0005599 biolink:CellularComponent collagen type X trimer A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets). go.json http://purl.obolibrary.org/obo/GO_0005599 GO:0005596 biolink:CellularComponent collagen type XIV trimer A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures. go.json http://purl.obolibrary.org/obo/GO_0005596 GO:0005597 biolink:CellularComponent collagen type XVI trimer A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils. go.json http://purl.obolibrary.org/obo/GO_0005597 GO:0005594 biolink:CellularComponent collagen type IX trimer A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils. go.json http://purl.obolibrary.org/obo/GO_0005594 GO:0005595 biolink:CellularComponent collagen type XII trimer A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures. go.json http://purl.obolibrary.org/obo/GO_0005595 RO:0002590 biolink:OntologyClass results in disassembly of RO:0002590 go.json http://purl.obolibrary.org/obo/RO_0002590 GO:0005592 biolink:CellularComponent collagen type XI trimer A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils. go.json http://purl.obolibrary.org/obo/GO_0005592 RO:0002591 biolink:OntologyClass results in remodeling of RO:0002591 go.json http://purl.obolibrary.org/obo/RO_0002591 GO:0005593 biolink:CellularComponent FACIT collagen trimer A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences. Wikipedia:FACIT_collagen go.json http://purl.obolibrary.org/obo/GO_0005593 RO:0002592 biolink:OntologyClass results in organization of RO:0002592 go.json http://purl.obolibrary.org/obo/RO_0002592 GO:0005590 biolink:CellularComponent collagen type VII trimer A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin. go.json http://purl.obolibrary.org/obo/GO_0005590 GO:0005591 biolink:CellularComponent collagen type VIII trimer A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets. go.json http://purl.obolibrary.org/obo/GO_0005591 RO:0002588 biolink:OntologyClass results in assembly of RO:0002588 go.json http://purl.obolibrary.org/obo/RO_0002588 GO:0030552 biolink:MolecularActivity cAMP binding Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). go.json 3',5' cAMP binding|3',5'-cAMP binding|adenosine 3',5'-cyclophosphate binding|cyclic AMP binding http://purl.obolibrary.org/obo/GO_0030552 GO:0030553 biolink:MolecularActivity cGMP binding Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). go.json 3',5' cGMP binding|3',5'-cGMP binding|cyclic GMP binding http://purl.obolibrary.org/obo/GO_0030553 GO:0030550 biolink:MolecularActivity acetylcholine receptor inhibitor activity Binds to and stops, prevents or reduces the activity of an acetylcholine receptor. go.json http://purl.obolibrary.org/obo/GO_0030550 GO:0030551 biolink:MolecularActivity cyclic nucleotide binding Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. go.json http://purl.obolibrary.org/obo/GO_0030551 GO:0030549 biolink:MolecularActivity acetylcholine receptor activator activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased. go.json http://purl.obolibrary.org/obo/GO_0030549 GO:0030547 biolink:MolecularActivity signaling receptor inhibitor activity Binds to and modulates the activity of a signaling receptor. go.json receptor inhibitor activity http://purl.obolibrary.org/obo/GO_0030547 GO:0030548 biolink:MolecularActivity acetylcholine receptor regulator activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. go.json http://purl.obolibrary.org/obo/GO_0030548 GO:0030545 biolink:MolecularActivity signaling receptor regulator activity Binds to and modulates the activity of a receptor. go.json receptor regulator activity http://purl.obolibrary.org/obo/GO_0030545 GO:0030546 biolink:MolecularActivity signaling receptor activator activity The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. go.json receptor activator activity|signalling receptor activator activity http://purl.obolibrary.org/obo/GO_0030546 GO:0030543 biolink:BiologicalProcess 2-micrometer plasmid partitioning The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division. go.json http://purl.obolibrary.org/obo/GO_0030543 GO:0030544 biolink:MolecularActivity Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. go.json http://purl.obolibrary.org/obo/GO_0030544 RO:0002578 biolink:OntologyClass directly regulates RO:0002578 go.json http://purl.obolibrary.org/obo/RO_0002578 GO:0030541 biolink:BiologicalProcess plasmid partitioning Any process in which plasmids are segregated or distributed into daughter cells upon cell division. go.json http://purl.obolibrary.org/obo/GO_0030541 GO:0030542 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030542 GO:0030540 biolink:BiologicalProcess female genitalia development The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. go.json female genital development http://purl.obolibrary.org/obo/GO_0030540 RO:0002565 biolink:OntologyClass results in movement of RO:0002565 go.json http://purl.obolibrary.org/obo/RO_0002565 RO:0002505 biolink:OntologyClass has intermediate RO:0002505 go.json http://purl.obolibrary.org/obo/RO_0002505 RO:0002608 biolink:OntologyClass process has causal agent RO:0002608 go.json http://purl.obolibrary.org/obo/RO_0002608 GO:0005505 biolink:MolecularActivity obsolete heavy metal binding OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. go.json heavy metal binding True http://purl.obolibrary.org/obo/GO_0005505 GO:0005506 biolink:MolecularActivity iron ion binding Binding to an iron (Fe) ion. go.json iron binding http://purl.obolibrary.org/obo/GO_0005506 GO:0005503 biolink:MolecularActivity all-trans retinal binding Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. go.json all-trans retinaldehyde binding|trans retinal binding|visual yellow binding|vitamin A binding|xanthopsin http://purl.obolibrary.org/obo/GO_0005503 GO:0005504 biolink:MolecularActivity fatty acid binding Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0005504 GO:0005501 biolink:MolecularActivity retinoid binding Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. Reactome:R-HSA-2454113|Reactome:R-HSA-2464809|Reactome:R-HSA-2465934|Reactome:R-HSA-2465938 go.json http://purl.obolibrary.org/obo/GO_0005501 GO:0005502 biolink:MolecularActivity 11-cis retinal binding Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. go.json 11-cis retinaldehyde binding|11-cis-retinal binding|vitamin A binding http://purl.obolibrary.org/obo/GO_0005502 GO:0005500 biolink:MolecularActivity juvenile hormone binding Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. go.json http://purl.obolibrary.org/obo/GO_0005500 GO:0005509 biolink:MolecularActivity calcium ion binding Binding to a calcium ion (Ca2+). go.json calcium ion storage activity http://purl.obolibrary.org/obo/GO_0005509 GO:0005507 biolink:MolecularActivity copper ion binding Binding to a copper (Cu) ion. go.json copper binding|copper/cadmium binding http://purl.obolibrary.org/obo/GO_0005507 GO:0005508 biolink:MolecularActivity obsolete copper/cadmium binding OBSOLETE. (Was not defined before being made obsolete). go.json copper/cadmium binding True http://purl.obolibrary.org/obo/GO_0005508 GO:0030538 biolink:BiologicalProcess embryonic genitalia morphogenesis The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized. go.json embryonic genital morphogenesis http://purl.obolibrary.org/obo/GO_0030538 GO:0030539 biolink:BiologicalProcess male genitalia development The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. go.json male genital development http://purl.obolibrary.org/obo/GO_0030539 GO:0030536 biolink:BiologicalProcess larval feeding behavior Feeding behavior in a larval (immature) organism. go.json larval feeding behaviour http://purl.obolibrary.org/obo/GO_0030536 GO:0030537 biolink:BiologicalProcess larval behavior Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics. go.json larval behaviour http://purl.obolibrary.org/obo/GO_0030537 GO:0030534 biolink:BiologicalProcess adult behavior Behavior in a fully developed and mature organism. go.json adult behavioral response to stimulus|adult behaviour|adult behavioural response to stimulus http://purl.obolibrary.org/obo/GO_0030534 GO:0005578 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005578 GO:0005579 biolink:CellularComponent membrane attack complex A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow. Wikipedia:Complement_membrane_attack_complex go.json MAC|TCC|membrane attack complex protein alphaM chain|membrane attack complex protein beta2 chain|terminal complement complex http://purl.obolibrary.org/obo/GO_0005579 GO:0030535 biolink:BiologicalProcess obsolete adult feeding behavior (sensu Insecta) OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects. go.json adult feeding behavior (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0030535 GO:0005576 biolink:CellularComponent extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. Wikipedia:Extracellular go.json extracellular http://purl.obolibrary.org/obo/GO_0005576 goslim_agr|goslim_candida|goslim_chembl|goslim_flybase_ribbon|goslim_generic|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0030532 biolink:CellularComponent small nuclear ribonucleoprotein complex A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. Wikipedia:SnRNP go.json small nuclear ribonucleoprotein|snRNP http://purl.obolibrary.org/obo/GO_0030532 goslim_pir GO:0030533 biolink:MolecularActivity triplet codon-amino acid adaptor activity The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. go.json tRNA|transfer RNA http://purl.obolibrary.org/obo/GO_0030533 goslim_candida|goslim_chembl|goslim_yeast GO:0005577 biolink:CellularComponent fibrinogen complex A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. go.json fibrinogen|fibrinogen alpha chain|fibrinogen beta chain|fibrinogen gamma chain http://purl.obolibrary.org/obo/GO_0005577 GO:0005574 biolink:CellularComponent obsolete DNA OBSOLETE. (Was not defined before being made obsolete). go.json DNA True http://purl.obolibrary.org/obo/GO_0005574 GO:0005575 biolink:CellularComponent cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). NIF_Subcellular:sao1337158144 go.json cell or subcellular entity|cellular component|subcellular entity http://purl.obolibrary.org/obo/GO_0005575 goslim_candida|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant|goslim_yeast GO:0005572 biolink:CellularComponent obsolete RNA polymerase II transcribed untranslated RNA OBSOLETE. (Was not defined before being made obsolete). go.json RNA polymerase II transcribed untranslated RNA True http://purl.obolibrary.org/obo/GO_0005572 GO:0005573 biolink:CellularComponent obsolete telomerase RNA OBSOLETE. (Was not defined before being made obsolete). go.json telomerase RNA True http://purl.obolibrary.org/obo/GO_0005573 GO:0005570 biolink:MolecularActivity obsolete small nuclear RNA OBSOLETE. (Was not defined before being made obsolete). go.json small nuclear RNA True http://purl.obolibrary.org/obo/GO_0005570 GO:0005571 biolink:CellularComponent obsolete untranslated RNA OBSOLETE. (Was not defined before being made obsolete). go.json untranslated RNA True http://purl.obolibrary.org/obo/GO_0005571 GO:0030530 biolink:CellularComponent obsolete heterogeneous nuclear ribonucleoprotein complex OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA. Wikipedia:Heterogeneous_ribonucleoprotein_particle go.json heterogeneous nuclear ribonucleoprotein|heterogeneous nuclear ribonucleoprotein complex|hnRNP True http://purl.obolibrary.org/obo/GO_0030530 GO:0030531 biolink:CellularComponent obsolete small cytoplasmic ribonucleoprotein complex OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm. go.json scRNP|small cytoplasmic ribonucleoprotein|small cytoplasmic ribonucleoprotein complex True http://purl.obolibrary.org/obo/GO_0030531 GO:0030527 biolink:MolecularActivity structural constituent of chromatin The action of a molecule that contributes to the structural integrity of chromatin. go.json http://purl.obolibrary.org/obo/GO_0030527 GO:0030528 biolink:MolecularActivity obsolete transcription regulator activity OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. go.json transcription regulator activity|transcriptional regulator activity True http://purl.obolibrary.org/obo/GO_0030528 GO:0030525 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030525 GO:0030526 biolink:CellularComponent granulocyte macrophage colony-stimulating factor receptor complex The heterodimeric receptor for granulocyte macrophage colony-stimulating factor. go.json GM-CSF receptor complex|granulocyte macrophage colony stimulating factor receptor complex http://purl.obolibrary.org/obo/GO_0030526 GO:0005589 biolink:CellularComponent collagen type VI trimer A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils. go.json http://purl.obolibrary.org/obo/GO_0005589 GO:0030523 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030523 GO:0030524 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030524 GO:0005587 biolink:CellularComponent collagen type IV trimer A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. Wikipedia:Collagen_type_IV go.json http://purl.obolibrary.org/obo/GO_0005587 GO:0030521 biolink:BiologicalProcess androgen receptor signaling pathway The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json androgen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0030521 GO:0030522 biolink:BiologicalProcess intracellular receptor signaling pathway The series of molecular signals initiated by a ligand binding to a receptor located within a cell. go.json intracellular receptor mediated signaling pathway|intracellular receptor-mediated signaling pathway|intracellular receptor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0030522 GO:0005588 biolink:CellularComponent collagen type V trimer A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils. go.json http://purl.obolibrary.org/obo/GO_0005588 GO:0005585 biolink:CellularComponent collagen type II trimer A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. Wikipedia:Collagen_type_II go.json http://purl.obolibrary.org/obo/GO_0005585 GO:0005586 biolink:CellularComponent collagen type III trimer A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils. go.json http://purl.obolibrary.org/obo/GO_0005586 GO:0005583 biolink:CellularComponent fibrillar collagen trimer Any triple helical collagen trimer that forms fibrils. go.json http://purl.obolibrary.org/obo/GO_0005583 GO:0005584 biolink:CellularComponent collagen type I trimer A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils. Wikipedia:Collagen_type_I go.json http://purl.obolibrary.org/obo/GO_0005584 GO:0005581 biolink:CellularComponent collagen trimer A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen go.json http://purl.obolibrary.org/obo/GO_0005581 GO:0005582 biolink:CellularComponent collagen type XV trimer A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils. go.json http://purl.obolibrary.org/obo/GO_0005582 GO:0030529 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030529 GO:0005580 biolink:CellularComponent obsolete membrane attack complex protein alphaM chain OBSOLETE. (Was not defined before being made obsolete). go.json membrane attack complex protein alphaM chain True http://purl.obolibrary.org/obo/GO_0005580 GO:0030520 biolink:BiologicalProcess intracellular estrogen receptor signaling pathway The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json estrogen receptor signaling pathway|estrogen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0030520 GO:0030516 biolink:BiologicalProcess regulation of axon extension Any process that modulates the rate, direction or extent of axon extension. go.json http://purl.obolibrary.org/obo/GO_0030516 GO:0030517 biolink:BiologicalProcess negative regulation of axon extension Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. go.json down regulation of axon extension|down-regulation of axon extension|downregulation of axon extension|inhibition of axon extension http://purl.obolibrary.org/obo/GO_0030517 GO:0030514 biolink:BiologicalProcess negative regulation of BMP signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. go.json down regulation of BMP signaling pathway|down-regulation of BMP signaling pathway|downregulation of BMP signaling pathway|inhibition of BMP signaling pathway|negative regulation of BMP receptor signaling pathway|negative regulation of BMP signalling pathway|negative regulation of bone morphogenetic protein signaling pathway|negative regulation of bone morphogenetic protein signalling pathway|negative regulation of decapentaplegic receptor signaling pathway|negative regulation of decapentaplegic receptor signalling pathway|negative regulation of decapentaplegic signaling pathway http://purl.obolibrary.org/obo/GO_0030514 GO:0005558 biolink:MolecularActivity obsolete minor histocompatibility antigen OBSOLETE. (Was not defined before being made obsolete). go.json minor histocompatibility antigen True http://purl.obolibrary.org/obo/GO_0005558 GO:0005559 biolink:CellularComponent obsolete ribozyme OBSOLETE. (Was not defined before being made obsolete). go.json ribozyme True http://purl.obolibrary.org/obo/GO_0005559 GO:0030515 biolink:MolecularActivity snoRNA binding Binding to a small nucleolar RNA. go.json http://purl.obolibrary.org/obo/GO_0030515 GO:0030512 biolink:BiologicalProcess negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. go.json down regulation of transforming growth factor beta receptor signaling pathway|down-regulation of transforming growth factor beta receptor signaling pathway|downregulation of transforming growth factor beta receptor signaling pathway|inhibition of transforming growth factor beta receptor signaling pathway|negative regulation of TGF-beta receptor signaling pathway|negative regulation of TGFbeta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signalling pathway http://purl.obolibrary.org/obo/GO_0030512 GO:0030513 biolink:BiologicalProcess positive regulation of BMP signaling pathway Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. go.json activation of BMP signaling pathway|positive regulation of BMP receptor signaling pathway|positive regulation of BMP signalling pathway|positive regulation of bone morphogenetic protein signaling pathway|positive regulation of bone morphogenetic protein signalling pathway|positive regulation of decapentaplegic receptor signaling pathway|positive regulation of decapentaplegic receptor signalling pathway|positive regulation of decapentaplegic signaling pathway|stimulation of BMP signaling pathway|up regulation of BMP signaling pathway|up-regulation of BMP signaling pathway|upregulation of BMP signaling pathway http://purl.obolibrary.org/obo/GO_0030513 GO:0005557 biolink:MolecularActivity obsolete lymphocyte antigen OBSOLETE. (Was not defined before being made obsolete). go.json lymphocyte antigen True http://purl.obolibrary.org/obo/GO_0005557 GO:0005554 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005554 GO:0030510 biolink:BiologicalProcess regulation of BMP signaling pathway Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. go.json regulation of BMP receptor signaling pathway|regulation of BMP signalling pathway|regulation of bone morphogenetic protein signaling pathway|regulation of bone morphogenetic protein signalling pathway|regulation of decapentaplegic receptor signaling pathway|regulation of decapentaplegic receptor signalling pathway|regulation of decapentaplegic signaling pathway http://purl.obolibrary.org/obo/GO_0030510 GO:0005555 biolink:MolecularActivity obsolete blood group antigen OBSOLETE. (Was not defined before being made obsolete). go.json blood group antigen True http://purl.obolibrary.org/obo/GO_0005555 GO:0030511 biolink:BiologicalProcess positive regulation of transforming growth factor beta receptor signaling pathway Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. go.json activation of transforming growth factor beta receptor signaling pathway|positive regulation of TGF-beta receptor signaling pathway|positive regulation of TGFbeta receptor signaling pathway|positive regulation of transforming growth factor beta receptor signalling pathway|stimulation of transforming growth factor beta receptor signaling pathway|up regulation of transforming growth factor beta receptor signaling pathway|up-regulation of transforming growth factor beta receptor signaling pathway|upregulation of transforming growth factor beta receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030511 GO:0005552 biolink:MolecularActivity obsolete polyubiquitin OBSOLETE. (Was not defined before being made obsolete). go.json polyubiquitin True http://purl.obolibrary.org/obo/GO_0005552 GO:0005553 biolink:MolecularActivity obsolete ubiquitin-ribosomal protein fusion protein OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein. go.json ubiquitin-ribosomal protein fusion protein True http://purl.obolibrary.org/obo/GO_0005553 GO:0005550 biolink:MolecularActivity pheromone binding Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. go.json http://purl.obolibrary.org/obo/GO_0005550 GO:0005551 biolink:MolecularActivity obsolete ubiquitin OBSOLETE. (Was not defined before being made obsolete). go.json True http://purl.obolibrary.org/obo/GO_0005551 GO:0030518 biolink:BiologicalProcess intracellular steroid hormone receptor signaling pathway The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. go.json steroid hormone receptor signaling pathway|steroid hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0030518 GO:0030519 biolink:MolecularActivity snoRNP binding Binding to a small nucleolar ribonucleoprotein particle. go.json http://purl.obolibrary.org/obo/GO_0030519 GO:0030505 biolink:BiologicalProcess inorganic diphosphate transport The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json inorganic pyrophosphate transport http://purl.obolibrary.org/obo/GO_0030505 GO:0030506 biolink:MolecularActivity ankyrin binding Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. go.json http://purl.obolibrary.org/obo/GO_0030506 GO:0030503 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0030503 GO:0005569 biolink:MolecularActivity obsolete small nucleolar RNA OBSOLETE. (Was not defined before being made obsolete). go.json small nucleolar RNA True http://purl.obolibrary.org/obo/GO_0005569 GO:0030504 biolink:MolecularActivity inorganic diphosphate transmembrane transporter activity Enables the transfer of inorganic diphosphate across a membrane. Reactome:R-HSA-5226964 go.json inorganic pyrophosphate transporter activity http://purl.obolibrary.org/obo/GO_0030504 GO:0030501 biolink:BiologicalProcess positive regulation of bone mineralization Any process that activates or increases the frequency, rate or extent of bone mineralization. go.json activation of bone mineralization|stimulation of bone mineralization|up regulation of bone mineralization|up-regulation of bone mineralization|upregulation of bone mineralization http://purl.obolibrary.org/obo/GO_0030501 GO:0005567 biolink:CellularComponent obsolete cytosolic ribosomal RNA OBSOLETE. (Was not defined before being made obsolete). go.json cytosolic ribosomal RNA True http://purl.obolibrary.org/obo/GO_0005567 GO:0030502 biolink:BiologicalProcess negative regulation of bone mineralization Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. go.json down regulation of bone mineralization|down-regulation of bone mineralization|downregulation of bone mineralization|inhibition of bone mineralization http://purl.obolibrary.org/obo/GO_0030502 GO:0005568 biolink:CellularComponent obsolete mitochondrial rRNA OBSOLETE. (Was not defined before being made obsolete). go.json mitochondrial rRNA True http://purl.obolibrary.org/obo/GO_0005568 GO:0005565 biolink:CellularComponent obsolete mitochondrial tRNA OBSOLETE. (Was not defined before being made obsolete). go.json mitochondrial tRNA True http://purl.obolibrary.org/obo/GO_0005565 GO:0005566 biolink:MolecularActivity obsolete ribosomal RNA OBSOLETE. (Was not defined before being made obsolete). go.json ribosomal RNA True http://purl.obolibrary.org/obo/GO_0005566 GO:0030500 biolink:BiologicalProcess regulation of bone mineralization Any process that modulates the frequency, rate or extent of bone mineralization. go.json http://purl.obolibrary.org/obo/GO_0030500 GO:0005563 biolink:MolecularActivity obsolete transfer RNA OBSOLETE. (Was not defined before being made obsolete). go.json transfer RNA True http://purl.obolibrary.org/obo/GO_0005563 GO:0005564 biolink:CellularComponent obsolete cytosolic tRNA OBSOLETE. (Was not defined before being made obsolete). go.json cytosolic tRNA True http://purl.obolibrary.org/obo/GO_0005564 GO:0005561 biolink:CellularComponent obsolete nucleic acid OBSOLETE. (Was not defined before being made obsolete). go.json nucleic acid True http://purl.obolibrary.org/obo/GO_0005561 GO:0005562 biolink:CellularComponent obsolete RNA OBSOLETE. (Was not defined before being made obsolete). go.json RNA True http://purl.obolibrary.org/obo/GO_0005562 GO:0030509 biolink:BiologicalProcess BMP signaling pathway The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json BMP receptor signaling pathway|BMP signalling pathway|bone morphogenetic protein signaling pathway|bone morphogenetic protein signalling pathway|decapentaplegic receptor signaling pathway|decapentaplegic receptor signalling pathway|decapentaplegic signaling pathway|dpp receptor signaling pathway|dpp receptor signalling pathway|dpp signaling pathway http://purl.obolibrary.org/obo/GO_0030509 GO:0030507 biolink:MolecularActivity spectrin binding Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. go.json http://purl.obolibrary.org/obo/GO_0030507 GO:0030508 biolink:MolecularActivity obsolete thiol-disulfide exchange intermediate activity OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions. go.json glutaredoxin|thiol-disulfide exchange intermediate activity|thiol-disulphide exchange intermediate activity|thioredoxin True http://purl.obolibrary.org/obo/GO_0030508 GO:0005539 biolink:MolecularActivity glycosaminoglycan binding Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. go.json http://purl.obolibrary.org/obo/GO_0005539 goslim_chembl GO:0005536 biolink:MolecularActivity glucose binding Binding to D- or L-enantiomers of glucose. go.json http://purl.obolibrary.org/obo/GO_0005536 GO:0005537 biolink:MolecularActivity mannose binding Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. Reactome:R-HSA-947991 go.json mannose binding lectin http://purl.obolibrary.org/obo/GO_0005537 goslim_chembl GO:0005534 biolink:MolecularActivity galactose binding Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. go.json galactose binding lectin http://purl.obolibrary.org/obo/GO_0005534 GO:0005532 biolink:MolecularActivity obsolete mannose binding lectin OBSOLETE. (Was not defined before being made obsolete). go.json mannose binding lectin|mannose receptor True http://purl.obolibrary.org/obo/GO_0005532 GO:0005533 biolink:MolecularActivity obsolete N-acetylgalactosamine lectin OBSOLETE. (Was not defined before being made obsolete). go.json N-acetylgalactosamine lectin True http://purl.obolibrary.org/obo/GO_0005533 GO:0005530 biolink:MolecularActivity obsolete lectin OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell. go.json lectin True http://purl.obolibrary.org/obo/GO_0005530 GO:0005531 biolink:MolecularActivity obsolete galactose binding lectin OBSOLETE. (Was not defined before being made obsolete). go.json galactose binding lectin True http://purl.obolibrary.org/obo/GO_0005531 GO:0005549 biolink:MolecularActivity odorant binding Binding to an odorant, any substance capable of stimulating the sense of smell. go.json http://purl.obolibrary.org/obo/GO_0005549 goslim_pir GO:0005547 biolink:MolecularActivity phosphatidylinositol-3,4,5-trisphosphate binding Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. go.json PIP3 binding http://purl.obolibrary.org/obo/GO_0005547 GO:0005548 biolink:MolecularActivity phospholipid transporter activity Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. Reactome:R-HSA-216757|Reactome:R-HSA-382553|Reactome:R-HSA-5678706|Reactome:R-HSA-5678749|Reactome:R-HSA-8857662|Reactome:R-HSA-8865637|Reactome:R-HSA-8867876 go.json http://purl.obolibrary.org/obo/GO_0005548 GO:0005545 biolink:MolecularActivity 1-phosphatidylinositol binding Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. go.json http://purl.obolibrary.org/obo/GO_0005545 GO:0005546 biolink:MolecularActivity phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. go.json 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding|PIP2 binding|PtdIns(4,5)P2 binding|phosphatidylinositol 4,5-bisphosphate binding http://purl.obolibrary.org/obo/GO_0005546 GO:0005543 biolink:MolecularActivity phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. go.json http://purl.obolibrary.org/obo/GO_0005543 GO:0005544 biolink:MolecularActivity calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. go.json http://purl.obolibrary.org/obo/GO_0005544 GO:0005541 biolink:MolecularActivity obsolete acyl-CoA or acyl binding OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid. go.json acyl-CoA or acyl binding True http://purl.obolibrary.org/obo/GO_0005541 GO:0005542 biolink:MolecularActivity folic acid binding Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. go.json folate binding|vitamin B9 binding|vitamin M binding http://purl.obolibrary.org/obo/GO_0005542 GO:0005540 biolink:MolecularActivity hyaluronic acid binding Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. go.json hyaluronan binding http://purl.obolibrary.org/obo/GO_0005540 GO:0005516 biolink:MolecularActivity calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. go.json http://purl.obolibrary.org/obo/GO_0005516 goslim_chembl OBO:GOREL_0001019 biolink:OntologyClass results in division of GOREL:0001019 go.json http://purl.obolibrary.org/obo/GOREL_0001019 GO:0005517 biolink:MolecularActivity obsolete calmodulin inhibitor activity OBSOLETE. This term was not defined before being made obsolete. go.json calmodulin inhibitor activity True http://purl.obolibrary.org/obo/GO_0005517 GO:0005514 biolink:MolecularActivity obsolete calcium ion storage activity OBSOLETE. (Was not defined before being made obsolete). go.json calcium ion storage activity True http://purl.obolibrary.org/obo/GO_0005514 GO:0005515 biolink:MolecularActivity protein binding Binding to a protein. go.json glycoprotein binding|protein amino acid binding http://purl.obolibrary.org/obo/GO_0005515 goslim_candida|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant GO:0005513 biolink:BiologicalProcess detection of calcium ion The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. go.json Ca2+ ion detection|calcium ion detection|calcium ion sensing|detection of Ca2+ ion http://purl.obolibrary.org/obo/GO_0005513 GO:0005518 biolink:MolecularActivity collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). go.json http://purl.obolibrary.org/obo/GO_0005518 GO:0005519 biolink:MolecularActivity cytoskeletal regulatory protein binding Binding to a protein involved in modulating the reorganization of the cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0005519 GO:0005527 biolink:MolecularActivity macrolide binding Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. go.json http://purl.obolibrary.org/obo/GO_0005527 GO:0005528 biolink:MolecularActivity FK506 binding Binding to a 23-membered macrolide lactone FK506. go.json FK506-sensitive peptidyl-prolyl cis-trans isomerase http://purl.obolibrary.org/obo/GO_0005528 GO:0005525 biolink:MolecularActivity GTP binding Binding to GTP, guanosine triphosphate. Reactome:R-HSA-167429 go.json http://purl.obolibrary.org/obo/GO_0005525 GO:0005523 biolink:MolecularActivity tropomyosin binding Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. go.json http://purl.obolibrary.org/obo/GO_0005523 GO:0005524 biolink:MolecularActivity ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. Reactome:R-HSA-265682 go.json Mg-ATP binding|MgATP binding http://purl.obolibrary.org/obo/GO_0005524 GO:0005521 biolink:MolecularActivity lamin binding Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. go.json lamin/chromatin binding http://purl.obolibrary.org/obo/GO_0005521 GO:0005522 biolink:MolecularActivity profilin binding Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. go.json http://purl.obolibrary.org/obo/GO_0005522 GO:0005520 biolink:MolecularActivity insulin-like growth factor binding Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. go.json IGF binding http://purl.obolibrary.org/obo/GO_0005520 goslim_chembl GO:0005529 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0005529 GO:0000820 biolink:BiologicalProcess regulation of glutamine family amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. go.json regulation of glutamine family amino acid metabolism http://purl.obolibrary.org/obo/GO_0000820 GO:0048800 biolink:BiologicalProcess antennal morphogenesis The process in which the anatomical structures of the antenna are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048800 GO:0048801 biolink:BiologicalProcess antennal joint morphogenesis The process in which the anatomical structures of the antennal joint are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048801 GO:0048802 biolink:BiologicalProcess notum morphogenesis The process in which the anatomical structures of the dorsal part of the body are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048802 GO:0000829 biolink:MolecularActivity inositol heptakisphosphate kinase activity Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown. Reactome:R-HSA-1855157|Reactome:R-HSA-1855182|Reactome:R-HSA-1855194 go.json http://purl.obolibrary.org/obo/GO_0000829 GO:0000825 biolink:MolecularActivity inositol tetrakisphosphate 6-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. MetaCyc:RXN-7184|Reactome:R-HSA-1855206 go.json 1D-myo-inositol-tetrakisphosphate 6-kinase activity|inositol 1,3,4,5-tetrakisphosphate 6-kinase activity http://purl.obolibrary.org/obo/GO_0000825 GO:0048803 biolink:BiologicalProcess imaginal disc-derived male genitalia morphogenesis The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc. go.json male genital morphogenesis http://purl.obolibrary.org/obo/GO_0048803 GO:0048804 biolink:BiologicalProcess imaginal disc-derived female genitalia morphogenesis The process in which the anatomical structures of female genitalia are generated and organized from the genital disc. go.json female genital morphogenesis http://purl.obolibrary.org/obo/GO_0048804 GO:0000826 biolink:MolecularActivity obsolete inositol pyrophosphate synthase activity OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds. go.json inositol diphosphate synthase activity|inositol pyrophosphate synthase activity True http://purl.obolibrary.org/obo/GO_0000826 GO:0000827 biolink:MolecularActivity inositol-1,3,4,5,6-pentakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. EC:2.7.4.21|Reactome:R-HSA-1855181|Reactome:R-HSA-1855223 go.json http://purl.obolibrary.org/obo/GO_0000827 GO:0048805 biolink:BiologicalProcess imaginal disc-derived genitalia morphogenesis The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc. go.json genital morphogenesis http://purl.obolibrary.org/obo/GO_0048805 GO:0000828 biolink:MolecularActivity inositol hexakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. Reactome:R-HSA-1855207|Reactome:R-HSA-1855216|Reactome:R-HSA-1855227 go.json IP6 kinase http://purl.obolibrary.org/obo/GO_0000828 GO:0048806 biolink:BiologicalProcess genitalia development The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. go.json genital development http://purl.obolibrary.org/obo/GO_0048806 GO:0048807 biolink:BiologicalProcess female genitalia morphogenesis The process in which the anatomical structures of female genitalia are generated and organized. go.json female genital morphogenesis http://purl.obolibrary.org/obo/GO_0048807 GO:0000821 biolink:BiologicalProcess regulation of arginine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. go.json regulation of arginine metabolism http://purl.obolibrary.org/obo/GO_0000821 GO:0000822 biolink:MolecularActivity inositol hexakisphosphate binding Binding to inositol hexakisphosphate. go.json IP6 binding|InsP6 binding http://purl.obolibrary.org/obo/GO_0000822 GO:0048808 biolink:BiologicalProcess male genitalia morphogenesis The process in which the anatomical structures of male genitalia are generated and organized. go.json male genital morphogenesis http://purl.obolibrary.org/obo/GO_0048808 GO:0000823 biolink:MolecularActivity inositol-1,4,5-trisphosphate 6-kinase activity Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H+. EC:2.7.1.151|KEGG_REACTION:R05800|MetaCyc:2.7.1.151-RXN go.json ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity|IpmK|inositol polyphosphate multikinase activity|inositol trisphosphate 6-kinase activity http://purl.obolibrary.org/obo/GO_0000823 GO:0048809 biolink:BiologicalProcess analia morphogenesis The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048809 GO:0000824 biolink:MolecularActivity inositol tetrakisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. RHEA:11856|Reactome:R-HSA-1855185 go.json 1D-myo-inositol-tetrakisphosphate 3-kinase activity|EC:2.7.1.151|IpmK|inositol 1,4,5,6-tetrakisphosphate 3-kinase activity|inositol polyphosphate multikinase activity http://purl.obolibrary.org/obo/GO_0000824 GO:0000830 biolink:MolecularActivity inositol hexakisphosphate 4-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate. go.json http://purl.obolibrary.org/obo/GO_0000830 GO:0000831 biolink:MolecularActivity inositol hexakisphosphate 6-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. go.json http://purl.obolibrary.org/obo/GO_0000831 GO:0048810 biolink:BiologicalProcess female analia morphogenesis The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048810 GO:0048811 biolink:BiologicalProcess male analia morphogenesis The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. go.json http://purl.obolibrary.org/obo/GO_0048811 GO:0048812 biolink:BiologicalProcess neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. go.json neurite biosynthesis|neurite formation|neurite growth|neurite morphogenesis http://purl.obolibrary.org/obo/GO_0048812 GO:0048813 biolink:BiologicalProcess dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048813 GO:0048814 biolink:BiologicalProcess regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0048814 GO:0000836 biolink:CellularComponent Hrd1p ubiquitin ligase complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78). go.json HRD1 ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0000836 GO:0048815 biolink:BiologicalProcess obsolete hermaphrodite genitalia morphogenesis OBSOLETE. The process in which the anatomical structures of hermaphrodite genitalia are generated and organized. go.json True http://purl.obolibrary.org/obo/GO_0048815 GO:0000837 biolink:CellularComponent Doa10p ubiquitin ligase complex A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p. go.json Ssm4p ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0000837 GO:0000838 biolink:CellularComponent Hrd1p ubiquitin ligase ERAD-M complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. go.json http://purl.obolibrary.org/obo/GO_0000838 GO:0048816 biolink:BiologicalProcess ocellus morphogenesis The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects. go.json http://purl.obolibrary.org/obo/GO_0048816 GO:0000839 biolink:CellularComponent Hrd1p ubiquitin ligase ERAD-L complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. go.json http://purl.obolibrary.org/obo/GO_0000839 GO:0048817 biolink:BiologicalProcess negative regulation of hair follicle maturation Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation. go.json down regulation of hair follicle maturation|down-regulation of hair follicle maturation|downregulation of hair follicle maturation|inhibition of hair follicle maturation http://purl.obolibrary.org/obo/GO_0048817 GO:0048818 biolink:BiologicalProcess positive regulation of hair follicle maturation Any process that activates or increases the frequency, rate or extent of hair follicle maturation. go.json activation of hair follicle maturation|stimulation of hair follicle maturation|up regulation of hair follicle maturation|up-regulation of hair follicle maturation|upregulation of hair follicle maturation http://purl.obolibrary.org/obo/GO_0048818 GO:0000832 biolink:MolecularActivity inositol hexakisphosphate 5-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. EC:2.7.4.21|KEGG_REACTION:R09087|MetaCyc:2.7.1.152-RXN|RHEA:12793 go.json ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0000832 GO:0000833 biolink:MolecularActivity inositol heptakisphosphate 4-kinase activity Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate. go.json IP7 4-kinase activity|diphosphoinositol-pentakisphosphate 4-kinase activity http://purl.obolibrary.org/obo/GO_0000833 GO:0048819 biolink:BiologicalProcess regulation of hair follicle maturation Any process that modulates the frequency, rate or extent of hair follicle maturation. go.json http://purl.obolibrary.org/obo/GO_0048819 GO:0000834 biolink:MolecularActivity inositol heptakisphosphate 6-kinase activity Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. go.json http://purl.obolibrary.org/obo/GO_0000834 GO:0000835 biolink:CellularComponent ER ubiquitin ligase complex A ubiquitin ligase complex found in the ER. go.json http://purl.obolibrary.org/obo/GO_0000835 GO:0048820 biolink:BiologicalProcess hair follicle maturation A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0048820 GO:0048821 biolink:BiologicalProcess erythrocyte development The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. go.json RBC development|red blood cell development http://purl.obolibrary.org/obo/GO_0048821 GO:0048822 biolink:BiologicalProcess enucleate erythrocyte development The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json enucleate RBC development|enucleate red blood cell development http://purl.obolibrary.org/obo/GO_0048822 GO:0048823 biolink:BiologicalProcess nucleate erythrocyte development The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json nucleate RBC development|nucleate red blood cell development http://purl.obolibrary.org/obo/GO_0048823 GO:0048824 biolink:BiologicalProcess pigment cell precursor differentiation The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor. go.json chromatophore precursor differentiation http://purl.obolibrary.org/obo/GO_0048824 GO:0000807 biolink:CellularComponent Z chromosome The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females. Wikipedia:ZW_sex-determination_system go.json http://purl.obolibrary.org/obo/GO_0000807 GO:0000808 biolink:CellularComponent origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. Wikipedia:Origin_recognition_complex go.json ORC|origin of replication recognition complex http://purl.obolibrary.org/obo/GO_0000808 goslim_pir GO:0000809 biolink:CellularComponent cytoplasmic origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm. go.json cytoplasmic ORC|prokaryotic ORC http://purl.obolibrary.org/obo/GO_0000809 GO:0048825 biolink:BiologicalProcess cotyledon development The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. go.json http://purl.obolibrary.org/obo/GO_0048825 GO:0000803 biolink:CellularComponent sex chromosome A chromosome involved in sex determination. go.json http://purl.obolibrary.org/obo/GO_0000803 GO:0000804 biolink:CellularComponent W chromosome The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females. Wikipedia:ZW_sex-determination_system go.json http://purl.obolibrary.org/obo/GO_0000804 GO:0048826 biolink:BiologicalProcess cotyledon morphogenesis The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. go.json http://purl.obolibrary.org/obo/GO_0048826 GO:0000805 biolink:CellularComponent X chromosome The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. Wikipedia:X_chromosome go.json http://purl.obolibrary.org/obo/GO_0000805 GO:0048827 biolink:BiologicalProcess phyllome development The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants. go.json http://purl.obolibrary.org/obo/GO_0048827 GO:0000806 biolink:CellularComponent Y chromosome The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males. Wikipedia:Y_chromosome go.json http://purl.obolibrary.org/obo/GO_0000806 GO:0048828 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048828 GO:0048829 biolink:BiologicalProcess root cap development The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant. go.json http://purl.obolibrary.org/obo/GO_0048829 GO:0000800 biolink:CellularComponent lateral element A proteinaceous core found between sister chromatids during meiotic prophase. go.json axial element http://purl.obolibrary.org/obo/GO_0000800 GO:0000801 biolink:CellularComponent central element A structural unit of the synaptonemal complex found between the lateral elements. go.json http://purl.obolibrary.org/obo/GO_0000801 GO:0000802 biolink:CellularComponent transverse filament A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them. go.json http://purl.obolibrary.org/obo/GO_0000802 GO:1902906 biolink:BiologicalProcess proteasome storage granule assembly The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule. go.json PSG assembly|PSG formation|proteasome storage granule formation|sequestration of proteasome core complex in proteasome storage granule http://purl.obolibrary.org/obo/GO_1902906 GO:1902907 biolink:BiologicalProcess proteasome storage granule disassembly The disaggregation of a proteasome storage granule into its constituent components. go.json PSG disassembly http://purl.obolibrary.org/obo/GO_1902907 GO:1902904 biolink:BiologicalProcess negative regulation of supramolecular fiber organization Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. go.json down regulation of fibril organisation|down regulation of fibril organization|down-regulation of fibril organisation|down-regulation of fibril organization|downregulation of fibril organisation|downregulation of fibril organization|inhibition of fibril organisation|inhibition of fibril organization|negative regulation of fibril organisation http://purl.obolibrary.org/obo/GO_1902904 GO:0048830 biolink:BiologicalProcess adventitious root development The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot. go.json http://purl.obolibrary.org/obo/GO_0048830 GO:1902905 biolink:BiologicalProcess positive regulation of supramolecular fiber organization Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. go.json activation of fibril organisation|activation of fibril organization|positive regulation of fibril organisation|up regulation of fibril organisation|up regulation of fibril organization|up-regulation of fibril organisation|up-regulation of fibril organization|upregulation of fibril organisation|upregulation of fibril organization http://purl.obolibrary.org/obo/GO_1902905 GO:0048831 biolink:BiologicalProcess regulation of shoot system development Any process that modulates the frequency, rate or extent of shoot development. go.json regulation of shoot development http://purl.obolibrary.org/obo/GO_0048831 GO:1902902 biolink:BiologicalProcess negative regulation of autophagosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly. go.json down regulation of PAS formation|down regulation of autophagic vacuole assembly|down regulation of autophagic vacuole formation|down regulation of autophagosome biosynthesis|down regulation of autophagosome formation|down-regulation of PAS formation|down-regulation of autophagic vacuole assembly|down-regulation of autophagic vacuole formation|down-regulation of autophagosome biosynthesis|down-regulation of autophagosome formation|downregulation of PAS formation|downregulation of autophagic vacuole assembly|downregulation of autophagic vacuole formation|downregulation of autophagosome biosynthesis|downregulation of autophagosome formation|inhibition of PAS formation|inhibition of autophagic vacuole assembly|inhibition of autophagic vacuole formation|inhibition of autophagosome biosynthesis|inhibition of autophagosome formation|negative regulation of PAS formation|negative regulation of autophagic vacuole assembly|negative regulation of autophagic vacuole formation|negative regulation of autophagosome biosynthesis|negative regulation of autophagosome formation http://purl.obolibrary.org/obo/GO_1902902 GO:0048832 biolink:BiologicalProcess specification of plant organ number The regionalization process that modulates the quantity of a particular type of plant organ. go.json http://purl.obolibrary.org/obo/GO_0048832 GO:1902903 biolink:BiologicalProcess regulation of supramolecular fiber organization Any process that modulates the frequency, rate or extent of supramolecular fiber organization. go.json regulation of fibril organisation http://purl.obolibrary.org/obo/GO_1902903 GO:0048833 biolink:BiologicalProcess specification of floral organ number Any process that modulates the number of floral organs formed in a floral whorl. go.json http://purl.obolibrary.org/obo/GO_0048833 GO:1902900 biolink:BiologicalProcess gut granule assembly The aggregation, arrangement and bonding together of a set of components to form a gut granule. go.json gut granule biogenesis|gut granule formation http://purl.obolibrary.org/obo/GO_1902900 GO:0048834 biolink:BiologicalProcess specification of petal number Any process that modulates the number of petals formed in a flower. go.json http://purl.obolibrary.org/obo/GO_0048834 GO:1902901 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion. go.json activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion|positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress|positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity|positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion|positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress|positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity|positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion True http://purl.obolibrary.org/obo/GO_1902901 GO:0048835 biolink:BiologicalProcess specification of decreased petal number Any process that reduces the number of petals produced in a developing flower. go.json http://purl.obolibrary.org/obo/GO_0048835 GO:0000818 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000818 GO:0000819 biolink:BiologicalProcess sister chromatid segregation The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. go.json http://purl.obolibrary.org/obo/GO_0000819 GO:0048836 biolink:BiologicalProcess specification of increased petal number Any process that increases the number of petals produced in a developing flower. go.json http://purl.obolibrary.org/obo/GO_0048836 GO:0000814 biolink:CellularComponent ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. go.json endosomal sorting complex required for transport http://purl.obolibrary.org/obo/GO_0000814 GO:0048837 biolink:BiologicalProcess sorocarp sorus development The process whose specific outcome is the progression of the sorocarp sorus over time, from its formation to the mature structure. A sorocarp sorus is the spore containing structure of a sorocarp. go.json sorocarp sorus formation|sorocarp spore head formation|sorocarp spore head morphogenesis http://purl.obolibrary.org/obo/GO_0048837 GO:0000815 biolink:CellularComponent ESCRT III complex A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission). go.json endosomal sorting complex required for transport http://purl.obolibrary.org/obo/GO_0000815 GO:0048838 biolink:BiologicalProcess release of seed from dormancy The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release. go.json http://purl.obolibrary.org/obo/GO_0048838 GO:0000816 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000816 GO:0000817 biolink:CellularComponent COMA complex A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p. go.json Ctf19p-Okp1p-Mcm1p-Ame1p complex http://purl.obolibrary.org/obo/GO_0000817 GO:0048839 biolink:BiologicalProcess inner ear development The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048839 GO:0000810 biolink:MolecularActivity diacylglycerol diphosphate phosphatase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate. EC:3.6.1.75|MetaCyc:RXN-11277|RHEA:27449 go.json DGPP phosphatase activity|DGPP phosphohydrolase activity|diacylglycerol pyrophosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0000810 GO:0000811 biolink:CellularComponent GINS complex A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. go.json Go, Ichi, Ni and San complex http://purl.obolibrary.org/obo/GO_0000811 GO:0000812 biolink:CellularComponent Swr1 complex A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. go.json SWR-C http://purl.obolibrary.org/obo/GO_0000812 GO:1902908 biolink:BiologicalProcess regulation of melanosome transport Any process that modulates the frequency, rate or extent of melanosome transport. go.json http://purl.obolibrary.org/obo/GO_1902908 GO:1902909 biolink:BiologicalProcess negative regulation of melanosome transport Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport. go.json down regulation of melanosome transport|down-regulation of melanosome transport|downregulation of melanosome transport|inhibition of melanosome transport http://purl.obolibrary.org/obo/GO_1902909 GO:0000813 biolink:CellularComponent ESCRT I complex An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. go.json endosomal sorting complex required for transport http://purl.obolibrary.org/obo/GO_0000813 GO:1902917 biolink:BiologicalProcess positive regulation of mating projection assembly Any process that activates or increases the frequency, rate or extent of mating projection assembly. go.json activation of mating projection assembly|activation of mating projection biogenesis|positive regulation of mating projection biogenesis|up regulation of mating projection assembly|up regulation of mating projection biogenesis|up-regulation of mating projection assembly|up-regulation of mating projection biogenesis|upregulation of mating projection assembly|upregulation of mating projection biogenesis http://purl.obolibrary.org/obo/GO_1902917 GO:1902918 biolink:BiologicalProcess poly(5-hydroxyvalerate) metabolic process The chemical reactions and pathways involving poly(5-hydroxyvalerate). go.json poly(5-hydroxyvalerate) metabolism http://purl.obolibrary.org/obo/GO_1902918 GO:0048840 biolink:BiologicalProcess otolith development The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048840 GO:1902915 biolink:BiologicalProcess negative regulation of protein polyubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination. go.json down regulation of polyubiquitin|down regulation of protein polyubiquitination|down regulation of protein polyubiquitinylation|down regulation of protein polyubiquitylation|down-regulation of polyubiquitin|down-regulation of protein polyubiquitination|down-regulation of protein polyubiquitinylation|down-regulation of protein polyubiquitylation|downregulation of polyubiquitin|downregulation of protein polyubiquitination|downregulation of protein polyubiquitinylation|downregulation of protein polyubiquitylation|inhibition of polyubiquitin|inhibition of protein polyubiquitination|inhibition of protein polyubiquitinylation|inhibition of protein polyubiquitylation|negative regulation of polyubiquitin|negative regulation of protein polyubiquitinylation|negative regulation of protein polyubiquitylation http://purl.obolibrary.org/obo/GO_1902915 GO:0048841 biolink:BiologicalProcess regulation of axon extension involved in axon guidance Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. go.json http://purl.obolibrary.org/obo/GO_0048841 GO:0048842 biolink:BiologicalProcess positive regulation of axon extension involved in axon guidance Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. go.json activation of axon extension involved in axon guidance|stimulation of axon extension involved in axon guidance|up regulation of axon extension involved in axon guidance|up-regulation of axon extension involved in axon guidance|upregulation of axon extension involved in axon guidance http://purl.obolibrary.org/obo/GO_0048842 GO:1902916 biolink:BiologicalProcess positive regulation of protein polyubiquitination Any process that activates or increases the frequency, rate or extent of protein polyubiquitination. go.json activation of polyubiquitin|activation of protein polyubiquitination|activation of protein polyubiquitinylation|activation of protein polyubiquitylation|positive regulation of polyubiquitin|positive regulation of protein polyubiquitinylation|positive regulation of protein polyubiquitylation|up regulation of polyubiquitin|up regulation of protein polyubiquitination|up regulation of protein polyubiquitinylation|up regulation of protein polyubiquitylation|up-regulation of polyubiquitin|up-regulation of protein polyubiquitination|up-regulation of protein polyubiquitinylation|up-regulation of protein polyubiquitylation|upregulation of polyubiquitin|upregulation of protein polyubiquitination|upregulation of protein polyubiquitinylation|upregulation of protein polyubiquitylation http://purl.obolibrary.org/obo/GO_1902916 GO:0048843 biolink:BiologicalProcess negative regulation of axon extension involved in axon guidance Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. go.json down regulation of axon extension involved in axon guidance|down-regulation of axon extension involved in axon guidance|downregulation of axon extension involved in axon guidance|inhibition of axon extension involved in axon guidance http://purl.obolibrary.org/obo/GO_0048843 GO:1902913 biolink:BiologicalProcess positive regulation of neuroepithelial cell differentiation Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. go.json activation of neuroepithelial cell differentiation|up regulation of neuroepithelial cell differentiation|up-regulation of neuroepithelial cell differentiation|upregulation of neuroepithelial cell differentiation http://purl.obolibrary.org/obo/GO_1902913 GO:1902914 biolink:BiologicalProcess regulation of protein polyubiquitination Any process that modulates the frequency, rate or extent of protein polyubiquitination. go.json regulation of polyubiquitin|regulation of protein polyubiquitinylation|regulation of protein polyubiquitylation http://purl.obolibrary.org/obo/GO_1902914 GO:0048844 biolink:BiologicalProcess artery morphogenesis The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. go.json arterial morphogenesis|arteriogenesis http://purl.obolibrary.org/obo/GO_0048844 GO:1902911 biolink:CellularComponent protein kinase complex A protein complex which is capable of protein kinase activity. go.json http://purl.obolibrary.org/obo/GO_1902911 GO:0048845 biolink:BiologicalProcess venous blood vessel morphogenesis The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. go.json vein morphogenesis|venous morphogenesis http://purl.obolibrary.org/obo/GO_0048845 GO:0048846 biolink:BiologicalProcess axon extension involved in axon guidance The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. go.json http://purl.obolibrary.org/obo/GO_0048846 GO:1902912 biolink:CellularComponent pyruvate kinase complex A protein complex which is capable of pyruvate kinase activity. go.json http://purl.obolibrary.org/obo/GO_1902912 GO:1902910 biolink:BiologicalProcess positive regulation of melanosome transport Any process that activates or increases the frequency, rate or extent of melanosome transport. go.json activation of melanosome transport|up regulation of melanosome transport|up-regulation of melanosome transport|upregulation of melanosome transport http://purl.obolibrary.org/obo/GO_1902910 GO:0048847 biolink:BiologicalProcess adenohypophysis formation The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. go.json adenophysis biosynthesis|adenophysis formation|anterior pituitary biosynthesis|anterior pituitary formation|anterior pituitary gland biosynthesis|anterior pituitary gland formation http://purl.obolibrary.org/obo/GO_0048847 GO:0048848 biolink:BiologicalProcess neurohypophysis morphogenesis The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. go.json neurophysis morphogenesis|posterior pituitary gland morphogenesis|posterior pituitary morphogenesis http://purl.obolibrary.org/obo/GO_0048848 GO:0048849 biolink:BiologicalProcess neurohypophysis formation The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. go.json neurophysis biosynthesis|neurophysis formation|posterior pituitary biosynthesis|posterior pituitary formation|posterior pituitary gland biosynthesis|posterior pituitary gland formation http://purl.obolibrary.org/obo/GO_0048849 GO:1902919 biolink:BiologicalProcess poly(5-hydroxyvalerate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(5-hydroxyvalerate). go.json poly(5-hydroxyvalerate) anabolism|poly(5-hydroxyvalerate) biosynthesis|poly(5-hydroxyvalerate) formation|poly(5-hydroxyvalerate) synthesis http://purl.obolibrary.org/obo/GO_1902919 GO:1902928 biolink:BiologicalProcess inulin biosynthetic process The chemical reactions and pathways resulting in the formation of inulin. go.json inulin anabolism|inulin biosynthesis|inulin formation|inulin synthesis http://purl.obolibrary.org/obo/GO_1902928 GO:0048850 biolink:BiologicalProcess hypophysis morphogenesis The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. go.json pituitary gland morphogenesis http://purl.obolibrary.org/obo/GO_0048850 GO:0048851 biolink:BiologicalProcess hypophysis formation The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands. go.json hypophysis biosynthesis|pituitary gland biosynthesis|pituitary gland formation http://purl.obolibrary.org/obo/GO_0048851 GO:1902929 biolink:CellularComponent plasma membrane of growing cell tip Any plasma membrane part that is part of a growing cell tip. go.json growing cell tip plasma membrane part|plasma membrane part of growing cell end|plasma membrane part of growing cell tip http://purl.obolibrary.org/obo/GO_1902929 GO:0048852 biolink:BiologicalProcess diencephalon morphogenesis The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. go.json http://purl.obolibrary.org/obo/GO_0048852 GO:1902926 biolink:BiologicalProcess inulin metabolic process The chemical reactions and pathways involving inulin. go.json inulin metabolism http://purl.obolibrary.org/obo/GO_1902926 GO:1902927 biolink:BiologicalProcess inulin catabolic process The chemical reactions and pathways resulting in the breakdown of inulin. go.json inulin breakdown|inulin catabolism|inulin degradation http://purl.obolibrary.org/obo/GO_1902927 GO:0048853 biolink:BiologicalProcess forebrain morphogenesis The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). go.json prosencephalon morphogenesis http://purl.obolibrary.org/obo/GO_0048853 GO:1902924 biolink:BiologicalProcess poly(hydroxyalkanoate) biosynthetic process from glucose The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from glucose. go.json poly(hydroxyalkanoate) anabolism from glucose|poly(hydroxyalkanoate) biosynthesis from glucose|poly(hydroxyalkanoate) formation from glucose|poly(hydroxyalkanoate) synthesis from glucose http://purl.obolibrary.org/obo/GO_1902924 GO:0048854 biolink:BiologicalProcess brain morphogenesis The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). go.json http://purl.obolibrary.org/obo/GO_0048854 GO:0048855 biolink:BiologicalProcess adenohypophysis morphogenesis The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. go.json adenophysis morphogenesis|anterior pituitary gland morphogenesis|anterior pituitary morphogenesis http://purl.obolibrary.org/obo/GO_0048855 GO:1902925 biolink:BiologicalProcess poly(hydroxyalkanoate) biosynthetic process from fatty acid The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from fatty acid. go.json poly(hydroxyalkanoate) anabolism from fatty acid|poly(hydroxyalkanoate) biosynthesis from fatty acid|poly(hydroxyalkanoate) formation from fatty acid|poly(hydroxyalkanoate) synthesis from fatty acid http://purl.obolibrary.org/obo/GO_1902925 GO:1902922 biolink:BiologicalProcess poly(3-hydroxyvalerate) metabolic process The chemical reactions and pathways involving poly(3-hydroxyvalerate). go.json poly(3-hydroxyvalerate) metabolism http://purl.obolibrary.org/obo/GO_1902922 GO:0048856 biolink:BiologicalProcess anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. go.json development of an anatomical structure http://purl.obolibrary.org/obo/GO_0048856 goslim_chembl|goslim_generic|goslim_plant GO:1902923 biolink:BiologicalProcess poly(3-hydroxyvalerate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(3-hydroxyvalerate). go.json poly(3-hydroxyvalerate) anabolism|poly(3-hydroxyvalerate) biosynthesis|poly(3-hydroxyvalerate) formation|poly(3-hydroxyvalerate) synthesis http://purl.obolibrary.org/obo/GO_1902923 GO:0048857 biolink:BiologicalProcess neural nucleus development The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. go.json http://purl.obolibrary.org/obo/GO_0048857 GO:1902920 biolink:BiologicalProcess poly(hydroxyvalerate) metabolic process The chemical reactions and pathways involving poly(hydroxyvalerate). go.json poly(hydroxyvalerate) metabolism http://purl.obolibrary.org/obo/GO_1902920 GO:1902921 biolink:BiologicalProcess poly(hydroxyvalerate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(hydroxyvalerate). go.json poly(hydroxyvalerate) anabolism|poly(hydroxyvalerate) biosynthesis|poly(hydroxyvalerate) formation|poly(hydroxyvalerate) synthesis http://purl.obolibrary.org/obo/GO_1902921 GO:0048858 biolink:BiologicalProcess cell projection morphogenesis The process in which the anatomical structures of a cell projection are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048858 GO:0048859 biolink:BiologicalProcess formation of anatomical boundary The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. go.json http://purl.obolibrary.org/obo/GO_0048859 GO:0034217 biolink:BiologicalProcess ascospore wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. go.json ascospore wall chitin anabolism|ascospore wall chitin biosynthesis|ascospore wall chitin formation|ascospore wall chitin synthesis http://purl.obolibrary.org/obo/GO_0034217 GO:0034218 biolink:BiologicalProcess ascospore wall chitin metabolic process The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. go.json ascospore wall chitin metabolism http://purl.obolibrary.org/obo/GO_0034218 GO:0010248 biolink:BiologicalProcess establishment or maintenance of transmembrane electrochemical gradient The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010248 GO:0034219 biolink:BiologicalProcess carbohydrate transmembrane transport The process in which a carbohydrate is transported across a membrane. go.json carbohydrate membrane transport|transmembrane carbohydrate transport http://purl.obolibrary.org/obo/GO_0034219 GO:0010249 biolink:BiologicalProcess auxin conjugate metabolic process The chemical reactions and pathways involving auxin conjugates, a bound form of auxin. go.json auxin conjugate metabolism http://purl.obolibrary.org/obo/GO_0010249 GO:0009260 biolink:BiologicalProcess ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json ribonucleotide anabolism|ribonucleotide biosynthesis|ribonucleotide formation|ribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009260 GO:0009261 biolink:BiologicalProcess ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json ribonucleotide breakdown|ribonucleotide catabolism|ribonucleotide degradation http://purl.obolibrary.org/obo/GO_0009261 GO:0009262 biolink:BiologicalProcess deoxyribonucleotide metabolic process The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json deoxyribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009262 GO:0009263 biolink:BiologicalProcess deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json deoxyribonucleotide anabolism|deoxyribonucleotide biosynthesis|deoxyribonucleotide formation|deoxyribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009263 GO:0009253 biolink:BiologicalProcess peptidoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. go.json murein catabolic process|murein catabolism|peptidoglycan breakdown|peptidoglycan catabolism|peptidoglycan degradation http://purl.obolibrary.org/obo/GO_0009253 GO:0010242 biolink:MolecularActivity oxygen evolving activity Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle. EC:1.10.3.9|MetaCyc:PSII-RXN|MetaCyc:RXN0-5265|RHEA:36359 go.json photosynthetic water oxidation http://purl.obolibrary.org/obo/GO_0010242 GO:0009254 biolink:BiologicalProcess peptidoglycan turnover The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall. go.json murein turnover http://purl.obolibrary.org/obo/GO_0009254 GO:0010243 biolink:BiologicalProcess response to organonitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. go.json response to organic nitrogen http://purl.obolibrary.org/obo/GO_0010243 GO:0034210 biolink:BiologicalProcess obsolete sterol deacetylation OBSOLETE. The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json True http://purl.obolibrary.org/obo/GO_0034210 GO:0009255 biolink:BiologicalProcess Entner-Doudoroff pathway through 6-phosphogluconate A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. MetaCyc:PWY-8004 go.json http://purl.obolibrary.org/obo/GO_0009255 GO:0010240 biolink:CellularComponent plastid pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria. go.json dehydrogenase complex http://purl.obolibrary.org/obo/GO_0010240 GO:0034211 biolink:MolecularActivity GTP-dependent protein kinase activity GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. go.json http://purl.obolibrary.org/obo/GO_0034211 GO:0010241 biolink:BiologicalProcess ent-kaurene oxidation to kaurenoic acid The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase. go.json ent-kaurene oxidation to ent-kaur-16-en-19-oate|ent-kaurene oxidation to ent-kaurenoate|ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase http://purl.obolibrary.org/obo/GO_0010241 GO:0034212 biolink:MolecularActivity peptide N-acetyltransferase activity Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. Reactome:R-HSA-3371554|Reactome:R-HSA-9760081 go.json http://purl.obolibrary.org/obo/GO_0034212 GO:0009256 biolink:BiologicalProcess 10-formyltetrahydrofolate metabolic process The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. go.json 10-formyl-THF metabolic process|10-formyl-THF metabolism|10-formyltetrahydrofolate metabolism http://purl.obolibrary.org/obo/GO_0009256 GO:0009257 biolink:BiologicalProcess 10-formyltetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. MetaCyc:1CMET2-PWY|MetaCyc:PWY-3841 go.json 10-formyl-THF biosynthesis|10-formyl-THF biosynthetic process|10-formyltetrahydrofolate anabolism|10-formyltetrahydrofolate biosynthesis|10-formyltetrahydrofolate formation|10-formyltetrahydrofolate synthesis http://purl.obolibrary.org/obo/GO_0009257 GO:0034213 biolink:BiologicalProcess quinolinate catabolic process The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. go.json quinolinate breakdown|quinolinate catabolism|quinolinate degradation http://purl.obolibrary.org/obo/GO_0034213 GO:0010246 biolink:BiologicalProcess rhamnogalacturonan I biosynthetic process The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide. go.json rhamnogalacturonan I anabolism|rhamnogalacturonan I biosynthesis|rhamnogalacturonan I formation|rhamnogalacturonan I synthesis http://purl.obolibrary.org/obo/GO_0010246 GO:0010247 biolink:BiologicalProcess detection of phosphate ion The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal. go.json phosphate ion detection|phosphate ion perception|phosphate ion sensing http://purl.obolibrary.org/obo/GO_0010247 GO:0034214 biolink:BiologicalProcess protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. go.json protein hexamer assembly|protein hexamer biosynthesis|protein hexamer biosynthetic process|protein hexamer formation http://purl.obolibrary.org/obo/GO_0034214 GO:0009258 biolink:BiologicalProcess 10-formyltetrahydrofolate catabolic process The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. go.json 10-formyl-THF catabolic process|10-formyl-THF catabolism|10-formyltetrahydrofolate breakdown|10-formyltetrahydrofolate catabolism|10-formyltetrahydrofolate degradation http://purl.obolibrary.org/obo/GO_0009258 GO:0009259 biolink:BiologicalProcess ribonucleotide metabolic process The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json ribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009259 GO:0010244 biolink:BiologicalProcess response to low fluence blue light stimulus by blue low-fluence system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes. go.json response to low fluence blue light|response to low fluence blue light by blf system http://purl.obolibrary.org/obo/GO_0010244 GO:0034215 biolink:MolecularActivity thiamine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). go.json thiamin:hydrogen symporter activity|thiamin:proton symporter activity|thiamine:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0034215 GO:0034216 biolink:MolecularActivity high-affinity thiamine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity thiamin:hydrogen symporter activity|high-affinity thiamin:hydrogen symporter activity|high-affinity thiamin:proton symporter activity|high-affinity thiamine:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0034216 GO:0010245 biolink:BiologicalProcess radial microtubular system formation Formation of radial microtubular systems during male meiotic cytokinesis in plants. go.json http://purl.obolibrary.org/obo/GO_0010245 GO:0034206 biolink:CellularComponent enhanceosome A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation. Wikipedia:Enhanceosome go.json http://purl.obolibrary.org/obo/GO_0034206 GO:0034207 biolink:BiologicalProcess obsolete steroid acetylation OBSOLETE. The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json True http://purl.obolibrary.org/obo/GO_0034207 GO:0034208 biolink:BiologicalProcess obsolete steroid deacetylation OBSOLETE. The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json True http://purl.obolibrary.org/obo/GO_0034208 GO:0010259 biolink:BiologicalProcess obsolete multicellular organism aging OBSOLETE. An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). go.json True http://purl.obolibrary.org/obo/GO_0010259 GO:0034209 biolink:BiologicalProcess obsolete sterol acetylation OBSOLETE. The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. go.json True http://purl.obolibrary.org/obo/GO_0034209 GO:0009270 biolink:BiologicalProcess response to humidity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. go.json http://purl.obolibrary.org/obo/GO_0009270 GO:0009271 biolink:BiologicalProcess phage shock A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. go.json http://purl.obolibrary.org/obo/GO_0009271 GO:0009272 biolink:BiologicalProcess fungal-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin. go.json chitin- and beta-glucan-containing cell wall biogenesis|fungal-type cell wall anabolism|fungal-type cell wall biosynthetic process|fungal-type cell wall formation|fungal-type cell wall synthesis http://purl.obolibrary.org/obo/GO_0009272 GO:0009273 biolink:BiologicalProcess peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. go.json cell envelope biosynthesis|cell envelope biosynthetic process|cell wall anabolism|cell wall assembly|cell wall biosynthetic process|cell wall formation|cell wall synthesis http://purl.obolibrary.org/obo/GO_0009273 GO:0009274 biolink:CellularComponent peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. go.json envelope|murein sacculus|peptidoglycan http://purl.obolibrary.org/obo/GO_0009274 GO:0010253 biolink:BiologicalProcess UDP-rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-3261 go.json UDP-rhamnose anabolism|UDP-rhamnose biosynthesis|UDP-rhamnose formation|UDP-rhamnose synthesis http://purl.obolibrary.org/obo/GO_0010253 GO:0009264 biolink:BiologicalProcess deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json deoxyribonucleotide breakdown|deoxyribonucleotide catabolism|deoxyribonucleotide degradation http://purl.obolibrary.org/obo/GO_0009264 GO:0009265 biolink:BiologicalProcess 2'-deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json 2'-deoxyribonucleotide anabolism|2'-deoxyribonucleotide biosynthesis|2'-deoxyribonucleotide formation|2'-deoxyribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009265 GO:0010254 biolink:BiologicalProcess nectary development The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0010254 GO:0010251 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010251 GO:0009266 biolink:BiologicalProcess response to temperature stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. go.json response to thermal stimulus http://purl.obolibrary.org/obo/GO_0009266 GO:0034200 biolink:MolecularActivity D,D-heptose 1,7-bisphosphate phosphatase activity Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate. MetaCyc:RXN0-4361|RHEA:28518 go.json http://purl.obolibrary.org/obo/GO_0034200 GO:0010252 biolink:BiologicalProcess obsolete auxin homeostasis OBSOLETE. A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. go.json True http://purl.obolibrary.org/obo/GO_0010252 GO:0009267 biolink:BiologicalProcess cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. go.json http://purl.obolibrary.org/obo/GO_0009267 GO:0034201 biolink:BiologicalProcess response to oleic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus. go.json response to oleate http://purl.obolibrary.org/obo/GO_0034201 GO:0010257 biolink:BiologicalProcess NADH dehydrogenase complex assembly The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. go.json http://purl.obolibrary.org/obo/GO_0010257 GO:0009268 biolink:BiologicalProcess response to pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. go.json http://purl.obolibrary.org/obo/GO_0009268 GO:0034202 biolink:MolecularActivity glycolipid floppase activity Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. Reactome:R-HSA-446212|Reactome:R-HSA-4570573 go.json ATP-dependent intramembrane glycolipid transporter activity|ATPase-coupled intramembrane glycolipid transporter activity|glycolipid floppase activity (cytosolic to exoplasmic leaftlet)|glycolipid-translocating activity http://purl.obolibrary.org/obo/GO_0034202 GO:0009269 biolink:BiologicalProcess response to desiccation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. go.json desiccation tolerance http://purl.obolibrary.org/obo/GO_0009269 GO:0034203 biolink:BiologicalProcess glycolipid translocation The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. go.json http://purl.obolibrary.org/obo/GO_0034203 GO:0010258 biolink:BiologicalProcess NADH dehydrogenase complex (plastoquinone) assembly The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I. go.json http://purl.obolibrary.org/obo/GO_0010258 GO:0034204 biolink:BiologicalProcess lipid translocation The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. go.json intramembrane lipid transfer http://purl.obolibrary.org/obo/GO_0034204 GO:0010255 biolink:BiologicalProcess glucose mediated signaling pathway The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes. go.json glucose mediated signalling http://purl.obolibrary.org/obo/GO_0010255 GO:0034205 biolink:BiologicalProcess amyloid-beta formation The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). go.json beta-amyloid formation|beta-amyloid polypeptide formation from APP|beta-amyloid polypeptide formation from amyloid precursor protein http://purl.obolibrary.org/obo/GO_0034205 GO:0010256 biolink:BiologicalProcess endomembrane system organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. go.json endomembrane organization|endomembrane system organisation http://purl.obolibrary.org/obo/GO_0010256 goslim_drosophila GO:0010250 biolink:BiologicalProcess S-methylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle. go.json S-methylmethionine anabolism|S-methylmethionine biosynthesis|S-methylmethionine formation|S-methylmethionine synthesis http://purl.obolibrary.org/obo/GO_0010250 GO:0010228 biolink:BiologicalProcess vegetative to reproductive phase transition of meristem The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence. go.json floral evocation|flowering|transition from vegetative to reproductive phase http://purl.obolibrary.org/obo/GO_0010228 GO:0010229 biolink:BiologicalProcess inflorescence development The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0010229 GO:0010226 biolink:BiologicalProcess response to lithium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0010226 GO:0010227 biolink:BiologicalProcess floral organ abscission The controlled shedding of floral organs. go.json http://purl.obolibrary.org/obo/GO_0010227 GO:0009240 biolink:BiologicalProcess isopentenyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. go.json IPP biosynthesis|IPP biosynthetic process|isopentenyl diphosphate anabolism|isopentenyl diphosphate biosynthesis|isopentenyl diphosphate formation|isopentenyl diphosphate synthesis|isopentenyl pyrophosphate biosynthesis|isopentenyl pyrophosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0009240 GO:0009241 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009241 GO:0010220 biolink:BiologicalProcess positive regulation of vernalization response Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. go.json activation of vernalization response|stimulation of vernalization response|up regulation of vernalization response|up-regulation of vernalization response|upregulation of vernalization response http://purl.obolibrary.org/obo/GO_0010220 GO:0009231 biolink:BiologicalProcess riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). MetaCyc:RIBOSYN2-PWY|Wikipedia:Riboflavin go.json riboflavin anabolism|riboflavin biosynthesis|riboflavin formation|riboflavin synthesis|vitamin B2 biosynthesis|vitamin B2 biosynthetic process|vitamin G biosynthesis|vitamin G biosynthetic process http://purl.obolibrary.org/obo/GO_0009231 GO:0009232 biolink:BiologicalProcess riboflavin catabolic process The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). go.json riboflavin breakdown|riboflavin catabolism|riboflavin degradation|vitamin B2 catabolic process|vitamin B2 catabolism|vitamin G catabolic process|vitamin G catabolism http://purl.obolibrary.org/obo/GO_0009232 GO:0010221 biolink:BiologicalProcess negative regulation of vernalization response Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. go.json down regulation of vernalization response|down-regulation of vernalization response|downregulation of vernalization response|inhibition of vernalization response http://purl.obolibrary.org/obo/GO_0010221 GO:0009233 biolink:BiologicalProcess menaquinone metabolic process The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. go.json menaquinone metabolism|menatetrenone metabolic process|menatetrenone metabolism|multiprenylmenaquinone metabolic process|multiprenylmenaquinone metabolism|vitamin K2 metabolic process|vitamin K2 metabolism http://purl.obolibrary.org/obo/GO_0009233 GO:0009234 biolink:BiologicalProcess menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. MetaCyc:MENAQUINONESYN-PWY go.json menaquinone anabolism|menaquinone biosynthesis|menaquinone formation|menaquinone synthesis|menatetrenone biosynthesis|menatetrenone biosynthetic process|multiprenylmenaquinone biosynthesis|multiprenylmenaquinone biosynthetic process|vitamin K2 biosynthesis|vitamin K2 biosynthetic process http://purl.obolibrary.org/obo/GO_0009234 GO:0009235 biolink:BiologicalProcess cobalamin metabolic process The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. go.json cobalamin metabolism|vitamin B12 metabolic process|vitamin B12 metabolism|vitamin B12 reduction http://purl.obolibrary.org/obo/GO_0009235 GO:0010224 biolink:BiologicalProcess response to UV-B Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. go.json response to UV-B light stimulus|response to UV-B radiation stimulus|response to UVB light stimulus|response to UVB radiation stimulus|response to medium wave ultraviolet light stimulus|response to medium wave ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_0010224 GO:0010225 biolink:BiologicalProcess response to UV-C Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. go.json response to UV-C light stimulus|response to UV-C radiation stimulus|response to UVC light stimulus|response to UVC radiation stimulus|response to germicidal ultraviolet light stimulus|response to germicidal ultraviolet radiation stimulus|response to shortwave ultraviolet light stimulus|response to shortwave ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_0010225 GO:0009236 biolink:BiologicalProcess cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. go.json cobalamin anabolism|cobalamin biosynthesis|cobalamin formation|cobalamin synthesis|vitamin B12 biosynthesis|vitamin B12 biosynthetic process http://purl.obolibrary.org/obo/GO_0009236 GO:0009237 biolink:BiologicalProcess siderophore metabolic process The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. go.json siderochrome metabolic process|siderochrome metabolism|siderophore metabolism http://purl.obolibrary.org/obo/GO_0009237 GO:0010222 biolink:BiologicalProcess stem vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the stem of vascular plants. go.json http://purl.obolibrary.org/obo/GO_0010222 GO:0010223 biolink:BiologicalProcess secondary shoot formation The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs. go.json auxiliary shoot formation|axillary shoot formation|axillary shoot system formation|shoot branching http://purl.obolibrary.org/obo/GO_0010223 GO:0009238 biolink:BiologicalProcess enterobactin metabolic process The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. go.json enterobactin metabolism|enterochelin metabolic process|enterochelin metabolism http://purl.obolibrary.org/obo/GO_0009238 GO:0009239 biolink:BiologicalProcess enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. MetaCyc:ENTBACSYN-PWY go.json enterobactin anabolism|enterobactin biosynthesis|enterobactin biosynthetic process, peptide formation|enterobactin biosynthetic process, peptide modification|enterobactin formation|enterobactin synthesis|enterobactin synthetase|enterochelin biosynthesis|enterochelin biosynthetic process http://purl.obolibrary.org/obo/GO_0009239 GO:0010239 biolink:BiologicalProcess chloroplast mRNA processing Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs. go.json http://purl.obolibrary.org/obo/GO_0010239 GO:0010237 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010237 GO:0010238 biolink:BiologicalProcess response to proline Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus. go.json http://purl.obolibrary.org/obo/GO_0010238 GO:0009250 biolink:BiologicalProcess glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. go.json glucan anabolism|glucan biosynthesis|glucan formation|glucan synthesis http://purl.obolibrary.org/obo/GO_0009250 GO:0009251 biolink:BiologicalProcess glucan catabolic process The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. go.json glucan breakdown|glucan catabolism|glucan degradation http://purl.obolibrary.org/obo/GO_0009251 GO:0009252 biolink:BiologicalProcess peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. go.json murein biosynthesis|murein biosynthetic process|peptidoglycan anabolism|peptidoglycan biosynthesis|peptidoglycan formation|peptidoglycan synthesis http://purl.obolibrary.org/obo/GO_0009252 GO:0009242 biolink:BiologicalProcess colanic acid biosynthetic process The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide. MetaCyc:COLANSYN-PWY go.json M antigen biosynthesis|M antigen biosynthetic process|colanic acid anabolism|colanic acid biosynthesis|colanic acid formation|colanic acid synthesis http://purl.obolibrary.org/obo/GO_0009242 GO:0010231 biolink:BiologicalProcess maintenance of seed dormancy Any process that maintains a seed in a dormant state. go.json http://purl.obolibrary.org/obo/GO_0010231 GO:0009243 biolink:BiologicalProcess O antigen biosynthetic process The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. go.json O antigen anabolism|O antigen biosynthesis|O antigen formation|O antigen synthesis http://purl.obolibrary.org/obo/GO_0009243 GO:0010232 biolink:BiologicalProcess vascular transport The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane. go.json http://purl.obolibrary.org/obo/GO_0010232 GO:0009244 biolink:BiologicalProcess lipopolysaccharide core region biosynthetic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. go.json LPS core region biosynthetic process|lipopolysaccharide core region anabolism|lipopolysaccharide core region biosynthesis|lipopolysaccharide core region formation|lipopolysaccharide core region synthesis http://purl.obolibrary.org/obo/GO_0009244 GO:0009245 biolink:BiologicalProcess lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. MetaCyc:NAGLIPASYN-PWY go.json lipid A anabolism|lipid A biosynthesis|lipid A formation|lipid A synthesis http://purl.obolibrary.org/obo/GO_0009245 GO:0010230 biolink:BiologicalProcess alternative respiration Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa. go.json http://purl.obolibrary.org/obo/GO_0010230 GO:0009246 biolink:BiologicalProcess enterobacterial common antigen biosynthetic process The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. MetaCyc:ECASYN-PWY go.json enterobacterial common antigen anabolism|enterobacterial common antigen biosynthesis|enterobacterial common antigen formation|enterobacterial common antigen synthesis http://purl.obolibrary.org/obo/GO_0009246 GO:0010235 biolink:BiologicalProcess guard mother cell cytokinesis The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells. go.json guard mother cell division http://purl.obolibrary.org/obo/GO_0010235 GO:0009247 biolink:BiologicalProcess glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). MetaCyc:PWY-401 go.json glycolipid anabolism|glycolipid biosynthesis|glycolipid formation|glycolipid synthesis http://purl.obolibrary.org/obo/GO_0009247 GO:0010236 biolink:BiologicalProcess plastoquinone biosynthetic process The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast. MetaCyc:PWY-1581 go.json plastoquinone anabolism|plastoquinone biosynthesis|plastoquinone formation|plastoquinone synthesis http://purl.obolibrary.org/obo/GO_0010236 GO:0009248 biolink:BiologicalProcess K antigen biosynthetic process The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. go.json K antigen anabolism|K antigen biosynthesis|K antigen formation|K antigen synthesis http://purl.obolibrary.org/obo/GO_0009248 GO:0010233 biolink:BiologicalProcess phloem transport The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues. go.json http://purl.obolibrary.org/obo/GO_0010233 GO:0009249 biolink:BiologicalProcess protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. go.json peptidyl-lysine lipoylation|protein-lipoic acid cofactor linkage http://purl.obolibrary.org/obo/GO_0009249 gocheck_do_not_annotate GO:0010234 biolink:BiologicalProcess anther wall tapetum cell fate specification The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json tapetal cell fate specification http://purl.obolibrary.org/obo/GO_0010234 GO:0010206 biolink:BiologicalProcess photosystem II repair Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition. go.json http://purl.obolibrary.org/obo/GO_0010206 GO:0010207 biolink:BiologicalProcess photosystem II assembly The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms. go.json http://purl.obolibrary.org/obo/GO_0010207 GO:0010204 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010204 GO:0010205 biolink:BiologicalProcess photoinhibition The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II. Wikipedia:Photoinhibition go.json photosystem II inhibition http://purl.obolibrary.org/obo/GO_0010205 GO:0010208 biolink:BiologicalProcess pollen wall assembly The formation of reticulate pollen wall pattern consisting of two layers, exine and intine. go.json pollen wall formation http://purl.obolibrary.org/obo/GO_0010208 GO:0010209 biolink:MolecularActivity vacuolar sorting signal binding Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole. go.json http://purl.obolibrary.org/obo/GO_0010209 GO:0009210 biolink:BiologicalProcess pyrimidine ribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json pyrimidine ribonucleoside triphosphate breakdown|pyrimidine ribonucleoside triphosphate catabolism|pyrimidine ribonucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009210 GO:0009211 biolink:BiologicalProcess pyrimidine deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json pyrimidine deoxyribonucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009211 GO:0009212 biolink:BiologicalProcess pyrimidine deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json pyrimidine deoxyribonucleoside triphosphate anabolism|pyrimidine deoxyribonucleoside triphosphate biosynthesis|pyrimidine deoxyribonucleoside triphosphate formation|pyrimidine deoxyribonucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009212 GO:0010202 biolink:BiologicalProcess response to low fluence red light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec. go.json http://purl.obolibrary.org/obo/GO_0010202 GO:0009213 biolink:BiologicalProcess pyrimidine deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json pyrimidine deoxyribonucleoside triphosphate breakdown|pyrimidine deoxyribonucleoside triphosphate catabolism|pyrimidine deoxyribonucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009213 GO:0010203 biolink:BiologicalProcess response to very low fluence red light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec. go.json http://purl.obolibrary.org/obo/GO_0010203 GO:0009214 biolink:BiologicalProcess cyclic nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. go.json cyclic nucleotide breakdown|cyclic nucleotide catabolism|cyclic nucleotide degradation http://purl.obolibrary.org/obo/GO_0009214 GO:0010200 biolink:BiologicalProcess response to chitin A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus. go.json http://purl.obolibrary.org/obo/GO_0010200 GO:0009215 biolink:BiologicalProcess purine deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json purine deoxyribonucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009215 GO:0010201 biolink:BiologicalProcess response to continuous far red light stimulus by the high-irradiance response system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence. go.json http://purl.obolibrary.org/obo/GO_0010201 GO:0009216 biolink:BiologicalProcess purine deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json purine deoxyribonucleoside triphosphate anabolism|purine deoxyribonucleoside triphosphate biosynthesis|purine deoxyribonucleoside triphosphate formation|purine deoxyribonucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009216 GO:0009217 biolink:BiologicalProcess purine deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json purine deoxyribonucleoside triphosphate breakdown|purine deoxyribonucleoside triphosphate catabolism|purine deoxyribonucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009217 GO:0009218 biolink:BiologicalProcess pyrimidine ribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine ribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009218 GO:0009219 biolink:BiologicalProcess pyrimidine deoxyribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine deoxyribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009219 GO:0010217 biolink:BiologicalProcess obsolete intracellular aluminum ion homeostasis OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of aluminium ions within a cell. go.json cellular aluminium ion homeostasis|cellular aluminum ion homeostasis True http://purl.obolibrary.org/obo/GO_0010217 GO:0010218 biolink:BiologicalProcess response to far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json response to far red light stimulus http://purl.obolibrary.org/obo/GO_0010218 GO:0010215 biolink:BiologicalProcess cellulose microfibril organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall. go.json cellulose microfibril organisation http://purl.obolibrary.org/obo/GO_0010215 GO:0010216 biolink:BiologicalProcess obsolete negative regulation of gene expression via chromosomal DNA cytosine methylation OBSOLETE. An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal DNA. go.json maintenance of DNA methylation True http://purl.obolibrary.org/obo/GO_0010216 GO:0010219 biolink:BiologicalProcess regulation of vernalization response Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. go.json http://purl.obolibrary.org/obo/GO_0010219 GO:0009230 biolink:BiologicalProcess thiamine catabolic process The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. go.json thiamin catabolic process|thiamine breakdown|thiamine catabolism|thiamine degradation|vitamin B1 catabolic process|vitamin B1 catabolism http://purl.obolibrary.org/obo/GO_0009230 GO:0009220 biolink:BiologicalProcess pyrimidine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. MetaCyc:PWY0-162 go.json pyrimidine ribonucleotide anabolism|pyrimidine ribonucleotide biosynthesis|pyrimidine ribonucleotide formation|pyrimidine ribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009220 GO:0009221 biolink:BiologicalProcess pyrimidine deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. MetaCyc:PWY0-166 go.json pyrimidine deoxyribonucleotide anabolism|pyrimidine deoxyribonucleotide biosynthesis|pyrimidine deoxyribonucleotide formation|pyrimidine deoxyribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009221 GO:0010210 biolink:MolecularActivity IAA-Phe conjugate hydrolase activity Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine. go.json http://purl.obolibrary.org/obo/GO_0010210 GO:0009222 biolink:BiologicalProcess pyrimidine ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine ribonucleotide breakdown|pyrimidine ribonucleotide catabolism|pyrimidine ribonucleotide degradation http://purl.obolibrary.org/obo/GO_0009222 GO:0009223 biolink:BiologicalProcess pyrimidine deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json pyrimidine deoxyribonucleotide breakdown|pyrimidine deoxyribonucleotide catabolism|pyrimidine deoxyribonucleotide degradation http://purl.obolibrary.org/obo/GO_0009223 GO:0009224 biolink:BiologicalProcess CMP biosynthetic process The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate. go.json CMP anabolism|CMP biosynthesis|CMP formation|CMP synthesis http://purl.obolibrary.org/obo/GO_0009224 GO:0010213 biolink:BiologicalProcess non-photoreactive DNA repair A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated. go.json light-independent DNA repair http://purl.obolibrary.org/obo/GO_0010213 GO:0010214 biolink:BiologicalProcess seed coat development The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0010214 GO:0009225 biolink:BiologicalProcess nucleotide-sugar metabolic process The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json nucleotide-sugar metabolism http://purl.obolibrary.org/obo/GO_0009225 goslim_pir GO:0009226 biolink:BiologicalProcess nucleotide-sugar biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json nucleotide-sugar anabolism|nucleotide-sugar biosynthesis|nucleotide-sugar formation|nucleotide-sugar synthesis http://purl.obolibrary.org/obo/GO_0009226 GO:0010211 biolink:MolecularActivity IAA-Leu conjugate hydrolase activity Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine. MetaCyc:RXN-2982 go.json http://purl.obolibrary.org/obo/GO_0010211 GO:0010212 biolink:BiologicalProcess response to ionizing radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. go.json response to ionising radiation|response to ionizing radiation stimulus http://purl.obolibrary.org/obo/GO_0010212 GO:0009227 biolink:BiologicalProcess nucleotide-sugar catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. go.json nucleotide-sugar breakdown|nucleotide-sugar catabolism|nucleotide-sugar degradation http://purl.obolibrary.org/obo/GO_0009227 GO:0009228 biolink:BiologicalProcess thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. MetaCyc:THISYN-PWY go.json thiamin anabolism|thiamin biosynthetic process|thiamine biosynthesis|thiamine formation|thiamine synthesis|vitamin B1 biosynthesis|vitamin B1 biosynthetic process http://purl.obolibrary.org/obo/GO_0009228 GO:0009229 biolink:BiologicalProcess thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. go.json TPP biosynthesis|TPP biosynthetic process|thiamin diphosphate biosynthetic process|thiamin pyrophosphate biosynthesis|thiamin pyrophosphate biosynthetic process|thiamine diphosphate anabolism|thiamine diphosphate biosynthesis|thiamine diphosphate formation|thiamine diphosphate synthesis|thiamine pyrophosphate biosynthesis|thiamine pyrophosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0009229 GO:0009200 biolink:BiologicalProcess deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json deoxyribonucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009200 GO:0009201 biolink:BiologicalProcess ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. go.json ribonucleoside triphosphate anabolism|ribonucleoside triphosphate biosynthesis|ribonucleoside triphosphate formation|ribonucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009201 GO:0009202 biolink:BiologicalProcess deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json deoxyribonucleoside triphosphate anabolism|deoxyribonucleoside triphosphate biosynthesis|deoxyribonucleoside triphosphate formation|deoxyribonucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009202 GO:0009203 biolink:BiologicalProcess ribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. go.json ribonucleoside triphosphate breakdown|ribonucleoside triphosphate catabolism|ribonucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009203 GO:0009204 biolink:BiologicalProcess deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. go.json deoxyribonucleoside triphosphate breakdown|deoxyribonucleoside triphosphate catabolism|deoxyribonucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009204 GO:0009205 biolink:BiologicalProcess purine ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json purine ribonucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009205 GO:0009206 biolink:BiologicalProcess purine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json purine ribonucleoside triphosphate anabolism|purine ribonucleoside triphosphate biosynthesis|purine ribonucleoside triphosphate formation|purine ribonucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009206 GO:0009207 biolink:BiologicalProcess purine ribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json purine ribonucleoside triphosphate breakdown|purine ribonucleoside triphosphate catabolism|purine ribonucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009207 GO:0009208 biolink:BiologicalProcess pyrimidine ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json pyrimidine ribonucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009208 GO:0009209 biolink:BiologicalProcess pyrimidine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. go.json pyrimidine ribonucleoside triphosphate anabolism|pyrimidine ribonucleoside triphosphate biosynthesis|pyrimidine ribonucleoside triphosphate formation|pyrimidine ribonucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009209 GO:0097751 biolink:BiologicalProcess spore-bearing structure formation The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores. go.json sporangium formation|sporophore formation http://purl.obolibrary.org/obo/GO_0097751 GO:0097752 biolink:BiologicalProcess regulation of DNA stability Any process that modulates the stability of DNA. go.json http://purl.obolibrary.org/obo/GO_0097752 GO:0097750 biolink:BiologicalProcess endosome membrane tubulation A membrane tubulation process occurring in an endosome membrane. go.json endosomal membrane tubulation http://purl.obolibrary.org/obo/GO_0097750 GO:1902898 biolink:BiologicalProcess fatty acid methyl ester metabolic process The chemical reactions and pathways involving fatty acid methyl ester. go.json FAME metabolic process|fatty acid methyl ester metabolism http://purl.obolibrary.org/obo/GO_1902898 GO:1902899 biolink:BiologicalProcess fatty acid methyl ester biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acid methyl ester. go.json FAME biosynthetic process|fatty acid methyl ester anabolism|fatty acid methyl ester biosynthesis|fatty acid methyl ester formation|fatty acid methyl ester synthesis http://purl.obolibrary.org/obo/GO_1902899 GO:1902896 biolink:BiologicalProcess terminal web assembly The aggregation, arrangement and bonding together of a set of components to form a terminal web. go.json terminal web formation http://purl.obolibrary.org/obo/GO_1902896 GO:1902897 biolink:BiologicalProcess regulation of postsynaptic density protein 95 clustering Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering. go.json regulation of Dlg4 clustering|regulation of PSD-95 clustering|regulation of post-synaptic density protein 95 clustering http://purl.obolibrary.org/obo/GO_1902897 GO:1902894 biolink:BiologicalProcess negative regulation of miRNA transcription Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription. go.json down regulation of pri-miRNA transcription from RNA polymerase II promoter|down-regulation of pri-miRNA transcription from RNA polymerase II promoter|downregulation of pri-miRNA transcription from RNA polymerase II promoter|inhibition of pri-miRNA transcription from RNA polymerase II promoter|negative regulation of miRNA gene transcription|negative regulation of microRNA gene transcription|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|negative regulation of primary miRNA gene transcription http://purl.obolibrary.org/obo/GO_1902894 GO:1902895 biolink:BiologicalProcess positive regulation of miRNA transcription Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription. go.json activation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of microRNA gene transcription|positive regulation of pri-miRNA gene transcription|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of primary miRNA gene transcription|up regulation of pri-miRNA transcription from RNA polymerase II promoter|up-regulation of pri-miRNA transcription from RNA polymerase II promoter|upregulation of pri-miRNA transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_1902895 GO:1902892 biolink:BiologicalProcess positive regulation of root hair elongation Any process that activates or increases the frequency, rate or extent of root hair elongation. go.json activation of root hair elongation|up regulation of root hair elongation|up-regulation of root hair elongation|upregulation of root hair elongation http://purl.obolibrary.org/obo/GO_1902892 GO:1902893 biolink:BiologicalProcess regulation of miRNA transcription Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription. go.json regulation of miRNA gene transcription|regulation of microRNA gene transcription|regulation of pri-miRNA transcription by RNA polymerase II|regulation of pri-miRNA transcription from RNA polymerase II promoter|regulation of primary miRNA gene transcription http://purl.obolibrary.org/obo/GO_1902893 GO:0034176 biolink:BiologicalProcess negative regulation of toll-like receptor 12 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway. go.json negative regulation of TLR12 signaling pathway|negative regulation of toll-like receptor 12 signalling pathway http://purl.obolibrary.org/obo/GO_0034176 GO:0034177 biolink:BiologicalProcess positive regulation of toll-like receptor 12 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway. go.json positive regulation of TLR12 signaling pathway|positive regulation of toll-like receptor 12 signalling pathway http://purl.obolibrary.org/obo/GO_0034177 GO:0034178 biolink:BiologicalProcess toll-like receptor 13 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 13. go.json TLR13 signaling pathway|toll-like receptor 13 signalling pathway http://purl.obolibrary.org/obo/GO_0034178 GO:0034179 biolink:BiologicalProcess regulation of toll-like receptor 13 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway. go.json regulation of TLR13 signaling pathway|regulation of toll-like receptor 13 signalling pathway http://purl.obolibrary.org/obo/GO_0034179 GO:0034170 biolink:BiologicalProcess toll-like receptor 11 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 11. go.json TLR11 signaling pathway|toll-like receptor 11 signalling pathway http://purl.obolibrary.org/obo/GO_0034170 GO:0034171 biolink:BiologicalProcess regulation of toll-like receptor 11 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway. go.json regulation of TLR11 signaling pathway|regulation of toll-like receptor 11 signalling pathway http://purl.obolibrary.org/obo/GO_0034171 GO:0034172 biolink:BiologicalProcess negative regulation of toll-like receptor 11 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway. go.json negative regulation of TLR11 signaling pathway|negative regulation of toll-like receptor 11 signalling pathway http://purl.obolibrary.org/obo/GO_0034172 GO:0097755 biolink:BiologicalProcess obsolete positive regulation of blood vessel diameter OBSOLETE. Any process that increases the diameter of blood vessels. go.json positive regulation of vasodilation True http://purl.obolibrary.org/obo/GO_0097755 GO:0097756 biolink:BiologicalProcess obsolete negative regulation of blood vessel diameter OBSOLETE. Any process that decreases the diameter of blood vessels. go.json negative regulation of vasodilation True http://purl.obolibrary.org/obo/GO_0097756 GO:0034173 biolink:BiologicalProcess positive regulation of toll-like receptor 11 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway. go.json positive regulation of TLR11 signaling pathway|positive regulation of toll-like receptor 11 signalling pathway http://purl.obolibrary.org/obo/GO_0034173 GO:0097753 biolink:BiologicalProcess membrane bending A membrane organization process resulting in the bending of a membrane. go.json membrane curvature http://purl.obolibrary.org/obo/GO_0097753 GO:0034174 biolink:BiologicalProcess toll-like receptor 12 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 12. go.json TLR12 signaling pathway|toll-like receptor 12 signalling pathway http://purl.obolibrary.org/obo/GO_0034174 GO:0034175 biolink:BiologicalProcess regulation of toll-like receptor 12 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway. go.json regulation of TLR12 signaling pathway|regulation of toll-like receptor 12 signalling pathway http://purl.obolibrary.org/obo/GO_0034175 GO:0097754 biolink:BiologicalProcess clathrin-mediated membrane bending A membrane bending process mediated by clathrin. go.json http://purl.obolibrary.org/obo/GO_0097754 GO:0034165 biolink:BiologicalProcess positive regulation of toll-like receptor 9 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway. go.json positive regulation of TLR9 signaling pathway|positive regulation of toll-like receptor 9 signalling pathway http://purl.obolibrary.org/obo/GO_0034165 GO:0034166 biolink:BiologicalProcess toll-like receptor 10 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 10. go.json TLR10 signaling pathway|toll-like receptor 10 signalling pathway http://purl.obolibrary.org/obo/GO_0034166 GO:0034167 biolink:BiologicalProcess regulation of toll-like receptor 10 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway. go.json regulation of TLR10 signaling pathway|regulation of toll-like receptor 10 signalling pathway http://purl.obolibrary.org/obo/GO_0034167 GO:0034168 biolink:BiologicalProcess negative regulation of toll-like receptor 10 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway. go.json negative regulation of TLR10 signaling pathway|negative regulation of toll-like receptor 10 signalling pathway http://purl.obolibrary.org/obo/GO_0034168 GO:0034169 biolink:BiologicalProcess positive regulation of toll-like receptor 10 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway. go.json positive regulation of TLR10 signaling pathway|positive regulation of toll-like receptor 10 signalling pathway http://purl.obolibrary.org/obo/GO_0034169 GO:0034160 biolink:BiologicalProcess negative regulation of toll-like receptor 8 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway. go.json negative regulation of TLR8 signaling pathway|negative regulation of toll-like receptor 8 signalling pathway http://purl.obolibrary.org/obo/GO_0034160 GO:0034161 biolink:BiologicalProcess positive regulation of toll-like receptor 8 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway. go.json positive regulation of TLR8 signaling pathway|positive regulation of toll-like receptor 8 signalling pathway http://purl.obolibrary.org/obo/GO_0034161 GO:0034162 biolink:BiologicalProcess toll-like receptor 9 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9. go.json TLR9 signaling pathway|toll-like receptor 9 signalling pathway http://purl.obolibrary.org/obo/GO_0034162 GO:0034163 biolink:BiologicalProcess regulation of toll-like receptor 9 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway. go.json regulation of TLR9 signaling pathway|regulation of toll-like receptor 9 signalling pathway http://purl.obolibrary.org/obo/GO_0034163 GO:0034164 biolink:BiologicalProcess negative regulation of toll-like receptor 9 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway. go.json negative regulation of TLR9 signaling pathway|negative regulation of toll-like receptor 9 signalling pathway http://purl.obolibrary.org/obo/GO_0034164 GO:0097730 biolink:CellularComponent non-motile cilium A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. go.json immotile cilium|immotile primary cilium|nonmotile cilium|nonmotile primary cilia|nonmotile primary cilium|sensory cilium http://purl.obolibrary.org/obo/GO_0097730 GO:0010187 biolink:BiologicalProcess negative regulation of seed germination Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination. go.json down regulation of seed germination|down-regulation of seed germination|downregulation of seed germination|inhibition of seed germination http://purl.obolibrary.org/obo/GO_0010187 GO:0034154 biolink:BiologicalProcess toll-like receptor 7 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 7. go.json TLR7 signaling pathway|toll-like receptor 7 signalling pathway http://purl.obolibrary.org/obo/GO_0034154 GO:0009198 biolink:BiologicalProcess pyrimidine deoxyribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json pyrimidine deoxyribonucleoside diphosphate breakdown|pyrimidine deoxyribonucleoside diphosphate catabolism|pyrimidine deoxyribonucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009198 GO:0034155 biolink:BiologicalProcess regulation of toll-like receptor 7 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway. go.json regulation of TLR7 signaling pathway|regulation of toll-like receptor 7 signalling pathway http://purl.obolibrary.org/obo/GO_0034155 GO:0010188 biolink:BiologicalProcess response to microbial phytotoxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants. go.json http://purl.obolibrary.org/obo/GO_0010188 GO:0009199 biolink:BiologicalProcess ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. go.json ribonucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009199 GO:0034156 biolink:BiologicalProcess negative regulation of toll-like receptor 7 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway. go.json negative regulation of TLR7 signaling pathway|negative regulation of toll-like receptor 7 signalling pathway http://purl.obolibrary.org/obo/GO_0034156 GO:0010185 biolink:BiologicalProcess regulation of cellular defense response Any process that modulates the frequency, rate or extent of cellular defense response. go.json regulation of cellular defence response http://purl.obolibrary.org/obo/GO_0010185 GO:0010186 biolink:BiologicalProcess positive regulation of cellular defense response Any process that activates or increases the frequency, rate or extent of cellular defense response. go.json activation of cellular defense response|positive regulation of cellular defence response|stimulation of cellular defense response|up regulation of cellular defense response|up-regulation of cellular defense response|upregulation of cellular defense response http://purl.obolibrary.org/obo/GO_0010186 GO:0034157 biolink:BiologicalProcess positive regulation of toll-like receptor 7 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway. go.json positive regulation of TLR7 signaling pathway|positive regulation of toll-like receptor 7 signalling pathway http://purl.obolibrary.org/obo/GO_0034157 GO:0034158 biolink:BiologicalProcess toll-like receptor 8 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8. go.json TLR8 signaling pathway|toll-like receptor 8 signalling pathway http://purl.obolibrary.org/obo/GO_0034158 GO:0034159 biolink:BiologicalProcess regulation of toll-like receptor 8 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway. go.json regulation of TLR8 signaling pathway|regulation of toll-like receptor 8 signalling pathway http://purl.obolibrary.org/obo/GO_0034159 GO:0097739 biolink:BiologicalProcess negative regulation of ferrichrome biosynthetic process in response to iron Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus. go.json http://purl.obolibrary.org/obo/GO_0097739 GO:0010189 biolink:BiologicalProcess vitamin E biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. MetaCyc:PWY-1422 go.json alpha-tocopherol biosynthesis|alpha-tocopherol biosynthetic process|tocopherol biosynthesis|tocopherol biosynthetic process|vitamin E anabolism|vitamin E biosynthesis|vitamin E formation|vitamin E synthesis http://purl.obolibrary.org/obo/GO_0010189 GO:0097737 biolink:BiologicalProcess acquisition of mycelium reproductive competence A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium. go.json mycelium developmental competence http://purl.obolibrary.org/obo/GO_0097737 GO:0010180 biolink:MolecularActivity thioglucosidase binding Binding to a thioglucosidase enzyme. go.json myrosinase binding http://purl.obolibrary.org/obo/GO_0010180 GO:0097738 biolink:BiologicalProcess substrate mycelium formation The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate. go.json http://purl.obolibrary.org/obo/GO_0097738 GO:0097735 biolink:CellularComponent DIM/DIP cell wall layer A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds. go.json http://purl.obolibrary.org/obo/GO_0097735 GO:0097736 biolink:BiologicalProcess aerial mycelium formation The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae. go.json aerial hyphal growth|fertile mycelium formation http://purl.obolibrary.org/obo/GO_0097736 GO:0034150 biolink:BiologicalProcess toll-like receptor 6 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 6. go.json TLR6 signaling pathway|toll-like receptor 6 signalling pathway http://purl.obolibrary.org/obo/GO_0034150 GO:0097733 biolink:CellularComponent photoreceptor cell cilium A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment. go.json photoreceptor cilium http://purl.obolibrary.org/obo/GO_0097733 GO:0010183 biolink:BiologicalProcess pollen tube guidance The process in which the growth of pollen tube is directed towards the female gametophyte. go.json http://purl.obolibrary.org/obo/GO_0010183 GO:0034151 biolink:BiologicalProcess regulation of toll-like receptor 6 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway. go.json regulation of TLR6 signaling pathway|regulation of toll-like receptor 6 signalling pathway http://purl.obolibrary.org/obo/GO_0034151 GO:0097734 biolink:BiologicalProcess extracellular exosome biogenesis The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. go.json ILV assembly|exosome assembly or secretion|exosome biogenesis|exosome production|intraluminal vesicle assembly http://purl.obolibrary.org/obo/GO_0097734 GO:0010184 biolink:BiologicalProcess cytokinin transport The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010184 GO:0034152 biolink:BiologicalProcess negative regulation of toll-like receptor 6 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway. go.json negative regulation of TLR6 signaling pathway|negative regulation of toll-like receptor 6 signalling pathway http://purl.obolibrary.org/obo/GO_0034152 GO:0097731 biolink:CellularComponent 9+0 non-motile cilium A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). go.json 9+0 immotile cilium|non-motile 9+0 cilium|primary cilium http://purl.obolibrary.org/obo/GO_0097731 GO:0010181 biolink:MolecularActivity FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. go.json flavin mononucleotide binding http://purl.obolibrary.org/obo/GO_0010181 GO:0097732 biolink:CellularComponent 9+2 non-motile cilium A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). go.json 9+2 immotile cilium|non-motile 9+2 cilium http://purl.obolibrary.org/obo/GO_0097732 GO:0034153 biolink:BiologicalProcess positive regulation of toll-like receptor 6 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway. go.json positive regulation of TLR6 signaling pathway|positive regulation of toll-like receptor 6 signalling pathway http://purl.obolibrary.org/obo/GO_0034153 GO:0010182 biolink:BiologicalProcess sugar mediated signaling pathway The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. go.json sugar mediated signalling http://purl.obolibrary.org/obo/GO_0010182 GO:0097740 biolink:CellularComponent paraflagellar rod A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signaling and metabolism, and in calcium signaling. go.json PFR http://purl.obolibrary.org/obo/GO_0097740 GO:0097741 biolink:CellularComponent mastigoneme A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum. go.json http://purl.obolibrary.org/obo/GO_0097741 GO:0034143 biolink:BiologicalProcess regulation of toll-like receptor 4 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. go.json regulation of TLR4 signaling pathway|regulation of toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0034143 GO:0010198 biolink:BiologicalProcess synergid death Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. go.json synergid cell death|synergid degeneration http://purl.obolibrary.org/obo/GO_0010198 GO:0034144 biolink:BiologicalProcess negative regulation of toll-like receptor 4 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway. go.json negative regulation of TLR4 signaling pathway|negative regulation of toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0034144 GO:0010199 biolink:BiologicalProcess organ boundary specification between lateral organs and the meristem The process in which boundaries between lateral organs and the meristem is established and maintained. go.json http://purl.obolibrary.org/obo/GO_0010199 GO:0034145 biolink:BiologicalProcess positive regulation of toll-like receptor 4 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. go.json positive regulation of TLR4 signaling pathway|positive regulation of toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0034145 GO:0010196 biolink:BiologicalProcess nonphotochemical quenching The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage. go.json http://purl.obolibrary.org/obo/GO_0010196 GO:0034146 biolink:BiologicalProcess toll-like receptor 5 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 5. go.json TLR5 signaling pathway|toll-like receptor 5 signalling pathway http://purl.obolibrary.org/obo/GO_0034146 GO:0010197 biolink:BiologicalProcess polar nucleus fusion The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized. go.json http://purl.obolibrary.org/obo/GO_0010197 GO:0034147 biolink:BiologicalProcess regulation of toll-like receptor 5 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway. go.json regulation of TLR5 signaling pathway|regulation of toll-like receptor 5 signalling pathway http://purl.obolibrary.org/obo/GO_0034147 GO:0034148 biolink:BiologicalProcess negative regulation of toll-like receptor 5 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway. go.json negative regulation of TLR5 signaling pathway|negative regulation of toll-like receptor 5 signalling pathway http://purl.obolibrary.org/obo/GO_0034148 GO:0034149 biolink:BiologicalProcess positive regulation of toll-like receptor 5 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway. go.json positive regulation of TLR5 signaling pathway|positive regulation of toll-like receptor 5 signalling pathway http://purl.obolibrary.org/obo/GO_0034149 GO:0097748 biolink:MolecularActivity 3'-5' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end. RHEA:57528 go.json http://purl.obolibrary.org/obo/GO_0097748 GO:0010190 biolink:BiologicalProcess cytochrome b6f complex assembly Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents. go.json cytochrome b6f complex biogenesis http://purl.obolibrary.org/obo/GO_0010190 GO:0010191 biolink:BiologicalProcess mucilage metabolic process The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants. go.json mucilage metabolism http://purl.obolibrary.org/obo/GO_0010191 goslim_pir GO:0097749 biolink:BiologicalProcess membrane tubulation A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules). go.json http://purl.obolibrary.org/obo/GO_0097749 GO:0097746 biolink:BiologicalProcess blood vessel diameter maintenance Any process that modulates the diameter of blood vessels. go.json blood vessel diameter homeostasis|regulation of blood vessel diameter|regulation of blood vessel size|regulation of vasodilatation|regulation of vasodilation http://purl.obolibrary.org/obo/GO_0097746 GO:0097747 biolink:MolecularActivity RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. go.json http://purl.obolibrary.org/obo/GO_0097747 GO:0010194 biolink:BiologicalProcess obsolete microRNA metabolic process OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity. go.json microRNA metabolic process True http://purl.obolibrary.org/obo/GO_0010194 GO:0097744 biolink:BiologicalProcess renal urate salt excretion The elimination of urate salt or uric acid from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. go.json urate excretion|urate salt excretion http://purl.obolibrary.org/obo/GO_0097744 GO:0034140 biolink:BiologicalProcess negative regulation of toll-like receptor 3 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway. go.json negative regulation of TLR3 signaling pathway|negative regulation of toll-like receptor 3 signalling pathway http://purl.obolibrary.org/obo/GO_0034140 GO:0010195 biolink:BiologicalProcess obsolete microRNA biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity. go.json miRNA biosynthesis|miRNA biosynthetic process|microRNA anabolism|microRNA biosynthesis|microRNA biosynthetic process|microRNA formation|microRNA synthesis True http://purl.obolibrary.org/obo/GO_0010195 GO:0097745 biolink:BiologicalProcess mitochondrial tRNA 5'-end processing The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0097745 GO:0034141 biolink:BiologicalProcess positive regulation of toll-like receptor 3 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway. go.json positive regulation of TLR3 signaling pathway|positive regulation of toll-like receptor 3 signalling pathway http://purl.obolibrary.org/obo/GO_0034141 GO:0010192 biolink:BiologicalProcess mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants. go.json mucilage anabolism|mucilage biosynthesis|mucilage formation|mucilage synthesis http://purl.obolibrary.org/obo/GO_0010192 GO:0097742 biolink:BiologicalProcess de novo centriole assembly Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects. go.json acentriolar basal body biogenesis|de novo basal body amplification|de novo basal body assembly|de novo basal body biogenesis|de novo basal body generation|de novo centriole amplification|de novo ciliary basal body assembly|multiciliation|multiciliogenesis http://purl.obolibrary.org/obo/GO_0097742 GO:0034142 biolink:BiologicalProcess toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 4. go.json TLR4 signaling pathway|toll-like receptor 4 signalling pathway http://purl.obolibrary.org/obo/GO_0034142 GO:0097743 biolink:BiologicalProcess de novo centriole assembly via blepharoplast A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface. go.json multiciliation|multiciliogenesis http://purl.obolibrary.org/obo/GO_0097743 GO:0010193 biolink:BiologicalProcess response to ozone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. go.json http://purl.obolibrary.org/obo/GO_0010193 GO:0009180 biolink:BiologicalProcess purine ribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar. go.json purine ribonucleoside diphosphate anabolism|purine ribonucleoside diphosphate biosynthesis|purine ribonucleoside diphosphate formation|purine ribonucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009180 GO:0009181 biolink:BiologicalProcess purine ribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar. go.json purine ribonucleoside diphosphate breakdown|purine ribonucleoside diphosphate catabolism|purine ribonucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009181 GO:0009182 biolink:BiologicalProcess purine deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json purine deoxyribonucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009182 GO:0009183 biolink:BiologicalProcess purine deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json purine deoxyribonucleoside diphosphate anabolism|purine deoxyribonucleoside diphosphate biosynthesis|purine deoxyribonucleoside diphosphate formation|purine deoxyribonucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009183 GO:0009184 biolink:BiologicalProcess purine deoxyribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json purine deoxyribonucleoside diphosphate breakdown|purine deoxyribonucleoside diphosphate catabolism|purine deoxyribonucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009184 GO:0009185 biolink:BiologicalProcess ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. go.json ribonucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009185 GO:0009186 biolink:BiologicalProcess deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json deoxyribonucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009186 GO:0009176 biolink:BiologicalProcess pyrimidine deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json pyrimidine deoxyribonucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009176 GO:0034132 biolink:BiologicalProcess negative regulation of toll-like receptor 1 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway. go.json negative regulation of TLR1 signaling pathway|negative regulation of toll-like receptor 1 signalling pathway http://purl.obolibrary.org/obo/GO_0034132 GO:0010165 biolink:BiologicalProcess response to X-ray Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). go.json response to X-ray radiation stimulus http://purl.obolibrary.org/obo/GO_0010165 GO:0009177 biolink:BiologicalProcess pyrimidine deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json pyrimidine deoxyribonucleoside monophosphate anabolism|pyrimidine deoxyribonucleoside monophosphate biosynthesis|pyrimidine deoxyribonucleoside monophosphate formation|pyrimidine deoxyribonucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009177 GO:0034133 biolink:BiologicalProcess positive regulation of toll-like receptor 1 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway. go.json positive regulation of TLR1 signaling pathway|positive regulation of toll-like receptor 1 signalling pathway http://purl.obolibrary.org/obo/GO_0034133 GO:0010166 biolink:BiologicalProcess wax metabolic process The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids. go.json wax metabolism http://purl.obolibrary.org/obo/GO_0010166 GO:0034134 biolink:BiologicalProcess toll-like receptor 2 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 2. go.json TLR2 signaling pathway|toll-like receptor 2 signalling pathway http://purl.obolibrary.org/obo/GO_0034134 GO:0009178 biolink:BiologicalProcess pyrimidine deoxyribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json pyrimidine deoxyribonucleoside monophosphate breakdown|pyrimidine deoxyribonucleoside monophosphate catabolism|pyrimidine deoxyribonucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009178 GO:0010163 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010163 GO:0010164 biolink:BiologicalProcess response to cesium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. go.json response to cesium http://purl.obolibrary.org/obo/GO_0010164 GO:0034135 biolink:BiologicalProcess regulation of toll-like receptor 2 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway. go.json regulation of TLR2 signaling pathway|regulation of toll-like receptor 2 signalling pathway http://purl.obolibrary.org/obo/GO_0034135 GO:0009179 biolink:BiologicalProcess purine ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar. go.json purine ribonucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009179 GO:0010169 biolink:CellularComponent thioglucosidase complex A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds. go.json myrosinase complex http://purl.obolibrary.org/obo/GO_0010169 GO:0034136 biolink:BiologicalProcess negative regulation of toll-like receptor 2 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway. go.json negative regulation of TLR2 signaling pathway|negative regulation of toll-like receptor 2 signalling pathway http://purl.obolibrary.org/obo/GO_0034136 GO:0034137 biolink:BiologicalProcess positive regulation of toll-like receptor 2 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway. go.json positive regulation of TLR2 signaling pathway|positive regulation of toll-like receptor 2 signalling pathway http://purl.obolibrary.org/obo/GO_0034137 GO:0010167 biolink:BiologicalProcess response to nitrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus. go.json http://purl.obolibrary.org/obo/GO_0010167 GO:0034138 biolink:BiologicalProcess toll-like receptor 3 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3. go.json TLR3 signaling pathway|toll-like receptor 3 signalling pathway http://purl.obolibrary.org/obo/GO_0034138 GO:0010168 biolink:CellularComponent ER body A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species. go.json endoplasmic reticulum body http://purl.obolibrary.org/obo/GO_0010168 GO:0034139 biolink:BiologicalProcess regulation of toll-like receptor 3 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway. go.json regulation of TLR3 signaling pathway|regulation of toll-like receptor 3 signalling pathway http://purl.obolibrary.org/obo/GO_0034139 GO:0010161 biolink:BiologicalProcess red light signaling pathway The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json red light phototransduction|red light signal transduction|red light signalling pathway http://purl.obolibrary.org/obo/GO_0010161 GO:0010162 biolink:BiologicalProcess seed dormancy process A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors. Wikipedia:Seed#Seed_dormancy_and_protection go.json seed dormancy http://purl.obolibrary.org/obo/GO_0010162 GO:0034130 biolink:BiologicalProcess toll-like receptor 1 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 1. go.json TLR1 signaling pathway|toll-like receptor 1 signalling pathway http://purl.obolibrary.org/obo/GO_0034130 GO:0010160 biolink:BiologicalProcess formation of animal organ boundary The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. go.json organ boundary specification http://purl.obolibrary.org/obo/GO_0010160 GO:0034131 biolink:BiologicalProcess regulation of toll-like receptor 1 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway. go.json regulation of TLR1 signaling pathway|regulation of toll-like receptor 1 signalling pathway http://purl.obolibrary.org/obo/GO_0034131 GO:0034129 biolink:BiologicalProcess positive regulation of MyD88-independent toll-like receptor signaling pathway Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. go.json positive regulation of MyD88-independent TLR signaling pathway|positive regulation of MyD88-independent toll-like receptor|positive regulation of MyD88-independent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034129 GO:0009190 biolink:BiologicalProcess cyclic nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. go.json cyclic nucleotide anabolism|cyclic nucleotide biosynthesis|cyclic nucleotide formation|cyclic nucleotide synthesis http://purl.obolibrary.org/obo/GO_0009190 GO:0009191 biolink:BiologicalProcess ribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. go.json ribonucleoside diphosphate breakdown|ribonucleoside diphosphate catabolism|ribonucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009191 GO:0009192 biolink:BiologicalProcess deoxyribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json deoxyribonucleoside diphosphate breakdown|deoxyribonucleoside diphosphate catabolism|deoxyribonucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009192 GO:0009193 biolink:BiologicalProcess pyrimidine ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar. go.json pyrimidine ribonucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009193 GO:0009194 biolink:BiologicalProcess pyrimidine ribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar. go.json pyrimidine ribonucleoside diphosphate anabolism|pyrimidine ribonucleoside diphosphate biosynthesis|pyrimidine ribonucleoside diphosphate formation|pyrimidine ribonucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009194 GO:0009195 biolink:BiologicalProcess pyrimidine ribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar. go.json pyrimidine ribonucleoside diphosphate breakdown|pyrimidine ribonucleoside diphosphate catabolism|pyrimidine ribonucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009195 GO:0009196 biolink:BiologicalProcess pyrimidine deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json pyrimidine deoxyribonucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009196 GO:0009197 biolink:BiologicalProcess pyrimidine deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json pyrimidine deoxyribonucleoside diphosphate anabolism|pyrimidine deoxyribonucleoside diphosphate biosynthesis|pyrimidine deoxyribonucleoside diphosphate formation|pyrimidine deoxyribonucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009197 GO:0034121 biolink:BiologicalProcess regulation of toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. go.json regulation of TLR signaling pathway|regulation of toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034121 GO:0010176 biolink:MolecularActivity homogentisate phytyltransferase activity Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol. KEGG_REACTION:R07500|MetaCyc:RXN-2541|RHEA:37975 go.json http://purl.obolibrary.org/obo/GO_0010176 GO:0009187 biolink:BiologicalProcess cyclic nucleotide metabolic process The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. go.json cyclic nucleotide metabolism http://purl.obolibrary.org/obo/GO_0009187 GO:0009188 biolink:BiologicalProcess ribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. go.json ribonucleoside diphosphate anabolism|ribonucleoside diphosphate biosynthesis|ribonucleoside diphosphate formation|ribonucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009188 GO:0034122 biolink:BiologicalProcess negative regulation of toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. go.json negative regulation of TLR signaling pathway|negative regulation of toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034122 GO:0010177 biolink:MolecularActivity 2-(2'-methylthio)ethylmalate synthase activity Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+. EC:2.3.3.17|MetaCyc:RXN-2202 go.json methylthioalkylmalate synthase activity http://purl.obolibrary.org/obo/GO_0010177 GO:0034123 biolink:BiologicalProcess positive regulation of toll-like receptor signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. go.json positive regulation of TLR signaling pathway|positive regulation of toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034123 GO:0010174 biolink:MolecularActivity nucleoside transmembrane transporter activity, against a concentration gradient Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient. go.json concentrative nucleoside transporter activity http://purl.obolibrary.org/obo/GO_0010174 GO:0009189 biolink:BiologicalProcess deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. go.json deoxyribonucleoside diphosphate anabolism|deoxyribonucleoside diphosphate biosynthesis|deoxyribonucleoside diphosphate formation|deoxyribonucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009189 GO:0034124 biolink:BiologicalProcess regulation of MyD88-dependent toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. go.json regulation ofMyD88-dependent TLR signaling pathway|regulation ofMyD88-dependent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034124 GO:0010175 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010175 GO:0034125 biolink:BiologicalProcess negative regulation of MyD88-dependent toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. go.json negative regulation of MyD88-dependent TLR signaling pathway|negative regulation of MyD88-dependent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034125 GO:0034126 biolink:BiologicalProcess positive regulation of MyD88-dependent toll-like receptor signaling pathway Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. go.json positive regulation of MyD88-dependent TLR signaling pathway|positive regulation of MyD88-dependent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034126 GO:0034127 biolink:BiologicalProcess regulation of MyD88-independent toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. go.json regulation ofMyD88-independent TLR signaling pathway|regulation ofMyD88-independent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034127 GO:0010178 biolink:MolecularActivity IAA-amino acid conjugate hydrolase activity Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid. go.json http://purl.obolibrary.org/obo/GO_0010178 GO:0034128 biolink:BiologicalProcess negative regulation of MyD88-independent toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. go.json negative regulation of MyD88-independent TLR signaling pathway|negative regulation of MyD88-independent toll-like receptor signalling pathway http://purl.obolibrary.org/obo/GO_0034128 GO:0010179 biolink:MolecularActivity IAA-Ala conjugate hydrolase activity Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine. MetaCyc:RXN-2981 go.json http://purl.obolibrary.org/obo/GO_0010179 GO:0010172 biolink:BiologicalProcess embryonic body morphogenesis The process in which the anatomical structures of the embryonic soma are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0010172 GO:0010173 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010173 GO:0010170 biolink:CellularComponent glucose-1-phosphate adenylyltransferase complex Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits. go.json http://purl.obolibrary.org/obo/GO_0010170 GO:0034120 biolink:BiologicalProcess positive regulation of erythrocyte aggregation Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation. go.json positive regulation of RBC aggregation|positive regulation of red blood cell aggregation http://purl.obolibrary.org/obo/GO_0034120 GO:0010171 biolink:BiologicalProcess body morphogenesis The process in which the anatomical structures of the soma are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0010171 GO:0034118 biolink:BiologicalProcess regulation of erythrocyte aggregation Any process that modulates the frequency, rate, or extent of erythrocyte aggregation. go.json regulation of RBC aggregation|regulation of red blood cell aggregation http://purl.obolibrary.org/obo/GO_0034118 GO:0034119 biolink:BiologicalProcess negative regulation of erythrocyte aggregation Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation. go.json negative regulation of RBC aggregation|negative regulation of red blood cell aggregation http://purl.obolibrary.org/obo/GO_0034119 GO:0010149 biolink:BiologicalProcess obsolete senescence OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed. Wikipedia:Senescence go.json senescence True http://purl.obolibrary.org/obo/GO_0010149 GO:0009161 biolink:BiologicalProcess ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. go.json ribonucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009161 GO:0009162 biolink:BiologicalProcess deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json deoxyribonucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009162 GO:0009163 biolink:BiologicalProcess nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json nucleoside anabolism|nucleoside biosynthesis|nucleoside formation|nucleoside synthesis http://purl.obolibrary.org/obo/GO_0009163 GO:0009164 biolink:BiologicalProcess nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json nucleoside breakdown|nucleoside catabolism|nucleoside degradation http://purl.obolibrary.org/obo/GO_0009164 GO:0034110 biolink:BiologicalProcess regulation of homotypic cell-cell adhesion Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0034110 GO:0010143 biolink:BiologicalProcess cutin biosynthetic process The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants. MetaCyc:PWY-321 go.json cutin anabolism|cutin biosynthesis|cutin formation|cutin synthesis http://purl.obolibrary.org/obo/GO_0010143 GO:0009154 biolink:BiologicalProcess purine ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine ribonucleotide breakdown|purine ribonucleotide catabolism|purine ribonucleotide degradation http://purl.obolibrary.org/obo/GO_0009154 GO:0009155 biolink:BiologicalProcess purine deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine deoxyribonucleotide breakdown|purine deoxyribonucleotide catabolism|purine deoxyribonucleotide degradation http://purl.obolibrary.org/obo/GO_0009155 GO:0010144 biolink:BiologicalProcess pyridoxal phosphate biosynthetic process from pyridoxamine The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine. go.json pyridoxal 5'-phosphate salvage from pyridoxamine|pyridoxal phosphate anabolism from pyridoxamine|pyridoxal phosphate formation from pyridoxamine|pyridoxal phosphate synthesis from pyridoxamine|vitamin B6 biosynthesis from pyridoxamine|vitamin B6 biosynthetic process from pyridoxamine http://purl.obolibrary.org/obo/GO_0010144 GO:0034111 biolink:BiologicalProcess negative regulation of homotypic cell-cell adhesion Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0034111 GO:0009156 biolink:BiologicalProcess ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. go.json ribonucleoside monophosphate anabolism|ribonucleoside monophosphate biosynthesis|ribonucleoside monophosphate formation|ribonucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009156 GO:0010141 biolink:BiologicalProcess obsolete guanine, xanthine and their nucleoside salvage OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis. go.json guanine, xanthine and their nucleoside salvage True http://purl.obolibrary.org/obo/GO_0010141 GO:0034112 biolink:BiologicalProcess positive regulation of homotypic cell-cell adhesion Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0034112 GO:0010142 biolink:BiologicalProcess farnesyl diphosphate biosynthetic process, mevalonate pathway The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols. MetaCyc:PWY-922 go.json Ac-MVA pathway|acetate-mevalonate pathway|farnesyl diphosphate anabolism, mevalonate pathway|farnesyl diphosphate formation, mevalonate pathway|farnesyl diphosphate synthesis, mevalonate pathway|isoprenoid pathway http://purl.obolibrary.org/obo/GO_0010142 GO:0009157 biolink:BiologicalProcess deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json deoxyribonucleoside monophosphate anabolism|deoxyribonucleoside monophosphate biosynthesis|deoxyribonucleoside monophosphate formation|deoxyribonucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009157 GO:0034113 biolink:BiologicalProcess heterotypic cell-cell adhesion The attachment of a cell to a cell of a different type via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0034113 GO:0010147 biolink:BiologicalProcess fructan catabolic process The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues. MetaCyc:PWY-862 go.json fructan breakdown|fructan catabolism|fructan degradation|levan catabolic process|levan catabolism http://purl.obolibrary.org/obo/GO_0010147 GO:0009158 biolink:BiologicalProcess ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. go.json ribonucleoside monophosphate breakdown|ribonucleoside monophosphate catabolism|ribonucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009158 GO:0034114 biolink:BiologicalProcess regulation of heterotypic cell-cell adhesion Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0034114 GO:0009159 biolink:BiologicalProcess deoxyribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json deoxyribonucleoside monophosphate breakdown|deoxyribonucleoside monophosphate catabolism|deoxyribonucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009159 GO:0010148 biolink:BiologicalProcess transpiration Release of water by the plant into the air as water vapor mainly through leaves. Wikipedia:Transpiration go.json http://purl.obolibrary.org/obo/GO_0010148 GO:0034115 biolink:BiologicalProcess negative regulation of heterotypic cell-cell adhesion Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0034115 GO:0034116 biolink:BiologicalProcess positive regulation of heterotypic cell-cell adhesion Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. go.json http://purl.obolibrary.org/obo/GO_0034116 GO:0010145 biolink:BiologicalProcess fructan metabolic process The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues. go.json fructan metabolism|levan metabolic process http://purl.obolibrary.org/obo/GO_0010145 GO:0034117 biolink:BiologicalProcess erythrocyte aggregation The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules. go.json RBC aggregation|red blood cell aggregation http://purl.obolibrary.org/obo/GO_0034117 GO:0010146 biolink:BiologicalProcess fructan biosynthetic process The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues. MetaCyc:PWY-822 go.json fructan anabolism|fructan biosynthesis|fructan formation|fructan synthesis|levan biosynthesis|levan biosynthetic process http://purl.obolibrary.org/obo/GO_0010146 GO:0010140 biolink:BiologicalProcess obsolete adenine, hypoxanthine and their nucleoside salvage OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis. go.json adenine, hypoxanthine and their nucleoside salvage True http://purl.obolibrary.org/obo/GO_0010140 GO:0034107 biolink:BiologicalProcess negative regulation of erythrocyte clearance Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance. go.json negative regulation of RBC clearance|negative regulation of neocytolysis|negative regulation of red blood cell clearance http://purl.obolibrary.org/obo/GO_0034107 GO:0034108 biolink:BiologicalProcess positive regulation of erythrocyte clearance Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance. go.json positive regulation of RBC clearance|positive regulation of neocytolysis|positive regulation of red blood cell clearance http://purl.obolibrary.org/obo/GO_0034108 GO:0034109 biolink:BiologicalProcess homotypic cell-cell adhesion The attachment of a cell to a second cell of the identical type via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0034109 GO:0009170 biolink:BiologicalProcess purine deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json purine deoxyribonucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009170 GO:0009171 biolink:BiologicalProcess purine deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json purine deoxyribonucleoside monophosphate anabolism|purine deoxyribonucleoside monophosphate biosynthesis|purine deoxyribonucleoside monophosphate formation|purine deoxyribonucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009171 GO:0009172 biolink:BiologicalProcess purine deoxyribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. go.json purine deoxyribonucleoside monophosphate breakdown|purine deoxyribonucleoside monophosphate catabolism|purine deoxyribonucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009172 GO:0009173 biolink:BiologicalProcess pyrimidine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. go.json pyrimidine ribonucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009173 GO:0009174 biolink:BiologicalProcess pyrimidine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. go.json pyrimidine ribonucleoside monophosphate anabolism|pyrimidine ribonucleoside monophosphate biosynthesis|pyrimidine ribonucleoside monophosphate formation|pyrimidine ribonucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009174 GO:0009175 biolink:BiologicalProcess pyrimidine ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. go.json pyrimidine ribonucleoside monophosphate breakdown|pyrimidine ribonucleoside monophosphate catabolism|pyrimidine ribonucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009175 GO:0009165 biolink:BiologicalProcess nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). go.json nucleotide anabolism|nucleotide biosynthesis|nucleotide formation|nucleotide synthesis http://purl.obolibrary.org/obo/GO_0009165 GO:0010154 biolink:BiologicalProcess fruit development The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant. go.json http://purl.obolibrary.org/obo/GO_0010154 GO:0034100 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034100 GO:0009166 biolink:BiologicalProcess nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). go.json nucleotide breakdown|nucleotide catabolism|nucleotide degradation http://purl.obolibrary.org/obo/GO_0009166 GO:0010155 biolink:BiologicalProcess regulation of proton transport Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010155 GO:0010152 biolink:BiologicalProcess pollen maturation The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains. go.json http://purl.obolibrary.org/obo/GO_0010152 GO:0034101 biolink:BiologicalProcess erythrocyte homeostasis Any process of regulating the production and elimination of erythrocytes within an organism. go.json RBC homeostasis|red blood cell homeostasis http://purl.obolibrary.org/obo/GO_0034101 GO:0009167 biolink:BiologicalProcess purine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. go.json purine ribonucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009167 GO:0034102 biolink:BiologicalProcess erythrocyte clearance The selective elimination of erythrocytes from the body by autoregulatory mechanisms. go.json RBC clearance|neocytolysis|red blood cell clearance http://purl.obolibrary.org/obo/GO_0034102 GO:0010153 biolink:BiologicalProcess obsolete polar cell elongation OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion. go.json polar cell elongation|polarity-dependent cell elongation True http://purl.obolibrary.org/obo/GO_0010153 GO:0009168 biolink:BiologicalProcess purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. go.json purine ribonucleoside monophosphate anabolism|purine ribonucleoside monophosphate biosynthesis|purine ribonucleoside monophosphate formation|purine ribonucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009168 GO:0034103 biolink:BiologicalProcess regulation of tissue remodeling Any process that modulates the frequency, rate, or extent of tissue remodeling. go.json regulation of tissue remodelling http://purl.obolibrary.org/obo/GO_0034103 GO:0009169 biolink:BiologicalProcess purine ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. go.json purine ribonucleoside monophosphate breakdown|purine ribonucleoside monophosphate catabolism|purine ribonucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009169 GO:0010158 biolink:BiologicalProcess abaxial cell fate specification The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0010158 GO:0034104 biolink:BiologicalProcess negative regulation of tissue remodeling Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. go.json negative regulation of tissue remodelling http://purl.obolibrary.org/obo/GO_0034104 GO:0010159 biolink:BiologicalProcess specification of animal organ position The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ. go.json http://purl.obolibrary.org/obo/GO_0010159 GO:0010156 biolink:BiologicalProcess obsolete sporocyte morphogenesis OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores. go.json sporocyte morphogenesis True http://purl.obolibrary.org/obo/GO_0010156 GO:0034105 biolink:BiologicalProcess positive regulation of tissue remodeling Any process that activates or increases the frequency, rate, or extent of tissue remodeling. go.json positive regulation of tissue remodelling http://purl.obolibrary.org/obo/GO_0034105 GO:0034106 biolink:BiologicalProcess regulation of erythrocyte clearance Any process that modulates the frequency, rate, or extent of erythrocyte clearance. go.json regulation of RBC clearance|regulation of neocytolysis|regulation of red blood cell clearance http://purl.obolibrary.org/obo/GO_0034106 GO:0010157 biolink:BiologicalProcess response to chlorate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus. go.json http://purl.obolibrary.org/obo/GO_0010157 GO:0010150 biolink:BiologicalProcess leaf senescence The last stage of leaf development during which programmed degradation of macromolecules and nutrient recycling take place. go.json http://purl.obolibrary.org/obo/GO_0010150 GO:0010151 biolink:BiologicalProcess chloroplast elongation Expansion of the chloroplast that usually precedes division. go.json http://purl.obolibrary.org/obo/GO_0010151 GO:0048740 biolink:BiologicalProcess obsolete striated muscle fiber development OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers. go.json myogenesis|striated muscle fiber development|striated muscle fibre development True http://purl.obolibrary.org/obo/GO_0048740 GO:1902818 biolink:BiologicalProcess ethyl acetate metabolic process The chemical reactions and pathways involving ethyl acetate. go.json ethyl acetate metabolism|ethyl ethanoate metabolic process http://purl.obolibrary.org/obo/GO_1902818 GO:1902819 biolink:BiologicalProcess ethyl acetate biosynthetic process The chemical reactions and pathways resulting in the formation of ethyl acetate. go.json ethyl acetate anabolism|ethyl acetate biosynthesis|ethyl acetate formation|ethyl acetate synthesis|ethyl ethanoate biosynthetic process http://purl.obolibrary.org/obo/GO_1902819 GO:0048741 biolink:BiologicalProcess skeletal muscle fiber development The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. go.json skeletal muscle fibre development|skeletal myofiber development|skeletal myofibre development http://purl.obolibrary.org/obo/GO_0048741 GO:0048742 biolink:BiologicalProcess regulation of skeletal muscle fiber development Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. go.json regulation of skeletal muscle fibre development|regulation of skeletal myofiber development|regulation of skeletal myofibre development http://purl.obolibrary.org/obo/GO_0048742 GO:1902816 biolink:BiologicalProcess regulation of protein localization to microtubule Any process that modulates the frequency, rate or extent of protein localization to microtubule. go.json regulation of protein localisation to microtubule http://purl.obolibrary.org/obo/GO_1902816 GO:1902817 biolink:BiologicalProcess negative regulation of protein localization to microtubule Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. go.json down regulation of protein localisation to microtubule|down regulation of protein localization to microtubule|down-regulation of protein localisation to microtubule|down-regulation of protein localization to microtubule|downregulation of protein localisation to microtubule|downregulation of protein localization to microtubule|inhibition of protein localisation to microtubule|inhibition of protein localization to microtubule|negative regulation of protein localisation to microtubule http://purl.obolibrary.org/obo/GO_1902817 GO:0048743 biolink:BiologicalProcess positive regulation of skeletal muscle fiber development Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. go.json activation of skeletal muscle fiber development|positive regulation of skeletal muscle fibre development|positive regulation of skeletal myofiber development|positive regulation of skeletal myofibre development|stimulation of skeletal muscle fiber development|up regulation of skeletal muscle fiber development|up-regulation of skeletal muscle fiber development|upregulation of skeletal muscle fiber development http://purl.obolibrary.org/obo/GO_0048743 GO:1902814 biolink:BiologicalProcess obsolete positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. go.json activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_1902814 GO:0048744 biolink:BiologicalProcess negative regulation of skeletal muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. go.json down regulation of skeletal muscle fiber development|down-regulation of skeletal muscle fiber development|downregulation of skeletal muscle fiber development|inhibition of skeletal muscle fiber development|negative regulation of skeletal muscle fibre development|negative regulation of skeletal myofiber development|negative regulation of skeletal myofibre development http://purl.obolibrary.org/obo/GO_0048744 GO:1902815 biolink:BiologicalProcess N,N'-diacetylchitobiose import The directed movement of N,N'-diacetylchitobiose into a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_1902815 GO:0048745 biolink:BiologicalProcess smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048745 GO:1902812 biolink:BiologicalProcess obsolete regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. go.json regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_1902812 GO:0048746 biolink:BiologicalProcess obsolete smooth muscle fiber development OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure. go.json smooth muscle fiber development|smooth muscle fibre development True http://purl.obolibrary.org/obo/GO_0048746 GO:1902813 biolink:BiologicalProcess obsolete negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. go.json down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_1902813 GO:0048747 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048747 GO:1902810 biolink:BiologicalProcess negative regulation of skeletal muscle fiber differentiation Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. go.json down regulation of skeletal muscle fiber differentiation|down-regulation of skeletal muscle fiber differentiation|downregulation of skeletal muscle fiber differentiation|inhibition of skeletal muscle fiber differentiation http://purl.obolibrary.org/obo/GO_1902810 GO:1902811 biolink:BiologicalProcess positive regulation of skeletal muscle fiber differentiation Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. go.json activation of skeletal muscle fiber differentiation|up regulation of skeletal muscle fiber differentiation|up-regulation of skeletal muscle fiber differentiation|upregulation of skeletal muscle fiber differentiation http://purl.obolibrary.org/obo/GO_1902811 GO:0048748 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048748 GO:0048749 biolink:BiologicalProcess compound eye development The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. go.json insect-type retina development http://purl.obolibrary.org/obo/GO_0048749 GO:0048751 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048751 GO:1902829 biolink:BiologicalProcess regulation of spinal cord association neuron differentiation Any process that modulates the frequency, rate or extent of spinal cord association neuron differentiation. go.json regulation of spinal cord dorsal interneuron differentiation http://purl.obolibrary.org/obo/GO_1902829 GO:0048752 biolink:BiologicalProcess semicircular canal morphogenesis The process in which the anatomical structures of the semicircular canals are generated and organized. go.json embryonic semicircular canal morphogenesis http://purl.obolibrary.org/obo/GO_0048752 GO:0048753 biolink:BiologicalProcess pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. go.json pigment granule organisation|pigment granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0048753 goslim_pir GO:1902827 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902827 GO:1902828 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902828 GO:0048754 biolink:BiologicalProcess branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. go.json tubulogenesis http://purl.obolibrary.org/obo/GO_0048754 GO:1902825 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902825 GO:0048755 biolink:BiologicalProcess branching morphogenesis of a nerve The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). go.json http://purl.obolibrary.org/obo/GO_0048755 GO:0048756 biolink:BiologicalProcess sieve cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. go.json http://purl.obolibrary.org/obo/GO_0048756 GO:1902826 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902826 GO:1902823 biolink:BiologicalProcess negative regulation of late endosome to lysosome transport Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport. go.json down regulation of late endosome to lysosome transport|down-regulation of late endosome to lysosome transport|downregulation of late endosome to lysosome transport|inhibition of late endosome to lysosome transport http://purl.obolibrary.org/obo/GO_1902823 GO:0048757 biolink:BiologicalProcess pigment granule maturation Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0048757 GO:0048758 biolink:BiologicalProcess companion cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member. go.json http://purl.obolibrary.org/obo/GO_0048758 GO:1902824 biolink:BiologicalProcess positive regulation of late endosome to lysosome transport Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport. go.json activation of late endosome to lysosome transport|up regulation of late endosome to lysosome transport|up-regulation of late endosome to lysosome transport|upregulation of late endosome to lysosome transport http://purl.obolibrary.org/obo/GO_1902824 GO:1902821 biolink:BiologicalProcess 1-undecene biosynthetic process The chemical reactions and pathways resulting in the formation of 1-undecene. go.json 1-undecene anabolism|1-undecene biosynthesis|1-undecene formation|1-undecene synthesis http://purl.obolibrary.org/obo/GO_1902821 GO:1902822 biolink:BiologicalProcess regulation of late endosome to lysosome transport Any process that modulates the frequency, rate or extent of late endosome to lysosome transport. go.json regulation of prevacuolar compartment to lysosome transport http://purl.obolibrary.org/obo/GO_1902822 GO:1902820 biolink:BiologicalProcess 1-undecene metabolic process The chemical reactions and pathways involving 1-undecene. go.json 1-undecene metabolism http://purl.obolibrary.org/obo/GO_1902820 GO:0048750 biolink:BiologicalProcess compound eye corneal lens morphogenesis The process in which the anatomical structures of the compound eye corneal lens are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048750 GO:0048759 biolink:BiologicalProcess xylem vessel member cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened. go.json vessel element cell differentiation|vessel member cell differentiation http://purl.obolibrary.org/obo/GO_0048759 GO:0048762 biolink:BiologicalProcess mesenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. go.json http://purl.obolibrary.org/obo/GO_0048762 GO:0048763 biolink:MolecularActivity calcium-induced calcium release activity Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration. go.json http://purl.obolibrary.org/obo/GO_0048763 GO:1902838 biolink:BiologicalProcess regulation of nuclear migration along microtubule Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. go.json regulation of microtubule cytoskeleton-dependent nuclear positioning|regulation of microtubule cytoskeleton-dependent nucleus positioning|regulation of microtubule-dependent nuclear positioning|regulation of microtubule-dependent nucleus positioning|regulation of microtubule-mediated nuclear migration|regulation of nuclear migration, microtubule-mediated|regulation of nuclear movement, microtubule-mediated|regulation of nucleus migration|regulation of transport of nucleus by microtubules|regulation of transport of nucleus, microtubule-mediated http://purl.obolibrary.org/obo/GO_1902838 GO:0048764 biolink:BiologicalProcess trichoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0048764 GO:0048765 biolink:BiologicalProcess root hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a root hair cell. go.json http://purl.obolibrary.org/obo/GO_0048765 GO:1902839 biolink:BiologicalProcess negative regulation of nuclear migration along microtubule Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. go.json down regulation of microtubule cytoskeleton-dependent nuclear positioning|down regulation of microtubule cytoskeleton-dependent nucleus positioning|down regulation of microtubule-dependent nuclear positioning|down regulation of microtubule-dependent nucleus positioning|down regulation of microtubule-mediated nuclear migration|down regulation of nuclear migration along microtubule|down regulation of nuclear migration, microtubule-mediated|down regulation of transport of nucleus by microtubules|down regulation of transport of nucleus, microtubule-mediated|down-regulation of microtubule cytoskeleton-dependent nuclear positioning|down-regulation of microtubule cytoskeleton-dependent nucleus positioning|down-regulation of microtubule-dependent nuclear positioning|down-regulation of microtubule-dependent nucleus positioning|down-regulation of microtubule-mediated nuclear migration|down-regulation of nuclear migration along microtubule|down-regulation of nuclear migration, microtubule-mediated|down-regulation of transport of nucleus by microtubules|down-regulation of transport of nucleus, microtubule-mediated|downregulation of microtubule cytoskeleton-dependent nuclear positioning|downregulation of microtubule cytoskeleton-dependent nucleus positioning|downregulation of microtubule-dependent nuclear positioning|downregulation of microtubule-dependent nucleus positioning|downregulation of microtubule-mediated nuclear migration|downregulation of nuclear migration along microtubule|downregulation of nuclear migration, microtubule-mediated|downregulation of transport of nucleus by microtubules|downregulation of transport of nucleus, microtubule-mediated|inhibition of microtubule cytoskeleton-dependent nuclear positioning|inhibition of microtubule cytoskeleton-dependent nucleus positioning|inhibition of microtubule-dependent nuclear positioning|inhibition of microtubule-dependent nucleus positioning|inhibition of microtubule-mediated nuclear migration|inhibition of nuclear migration along microtubule|inhibition of nuclear migration, microtubule-mediated|inhibition of transport of nucleus by microtubules|inhibition of transport of nucleus, microtubule-mediated|negative regulation of microtubule cytoskeleton-dependent nuclear positioning|negative regulation of microtubule cytoskeleton-dependent nucleus positioning|negative regulation of microtubule-dependent nuclear positioning|negative regulation of microtubule-dependent nucleus positioning|negative regulation of microtubule-mediated nuclear migration|negative regulation of nuclear migration, microtubule-mediated|negative regulation of transport of nucleus by microtubules|negative regulation of transport of nucleus, microtubule-mediated http://purl.obolibrary.org/obo/GO_1902839 GO:1902836 biolink:BiologicalProcess positive regulation of proline import across plasma membrane Any process that activates or increases the frequency, rate or extent of proline import into cell. go.json activation of proline import into cell|positive regulation of proline import into cell|up regulation of proline import into cell|up-regulation of proline import into cell|upregulation of proline import into cell http://purl.obolibrary.org/obo/GO_1902836 GO:0048766 biolink:BiologicalProcess root hair initiation The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth. go.json http://purl.obolibrary.org/obo/GO_0048766 GO:1902837 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902837 GO:0048767 biolink:BiologicalProcess root hair elongation The process in which the root hair grows longer. go.json http://purl.obolibrary.org/obo/GO_0048767 GO:1902834 biolink:BiologicalProcess regulation of proline import across plasma membrane Any process that modulates the frequency, rate or extent of proline import into cell. go.json regulation of proline import into cell http://purl.obolibrary.org/obo/GO_1902834 GO:0048768 biolink:BiologicalProcess root hair cell tip growth Localized growth of a plant root hair tip by extension of the cell wall. go.json root hair tip growth http://purl.obolibrary.org/obo/GO_0048768 GO:0048769 biolink:BiologicalProcess sarcomerogenesis The process in which sarcomeres are added in series within a fiber. go.json myofibril production http://purl.obolibrary.org/obo/GO_0048769 GO:1902835 biolink:BiologicalProcess negative regulation of proline import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell. go.json down regulation of proline import into cell|down-regulation of proline import into cell|downregulation of proline import into cell|inhibition of proline import into cell|negative regulation of proline import into cell http://purl.obolibrary.org/obo/GO_1902835 GO:1902832 biolink:BiologicalProcess negative regulation of cell proliferation in dorsal spinal cord Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord. go.json down regulation of cell proliferation in dorsal spinal cord|down-regulation of cell proliferation in dorsal spinal cord|downregulation of cell proliferation in dorsal spinal cord|inhibition of cell proliferation in dorsal spinal cord http://purl.obolibrary.org/obo/GO_1902832 GO:1902833 biolink:BiologicalProcess positive regulation of cell proliferation in dorsal spinal cord Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord. go.json activation of cell proliferation in dorsal spinal cord|up regulation of cell proliferation in dorsal spinal cord|up-regulation of cell proliferation in dorsal spinal cord|upregulation of cell proliferation in dorsal spinal cord http://purl.obolibrary.org/obo/GO_1902833 GO:1902830 biolink:BiologicalProcess negative regulation of spinal cord association neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of spinal cord association neuron differentiation. go.json down regulation of spinal cord association neuron differentiation|down regulation of spinal cord dorsal interneuron differentiation|down-regulation of spinal cord association neuron differentiation|down-regulation of spinal cord dorsal interneuron differentiation|downregulation of spinal cord association neuron differentiation|downregulation of spinal cord dorsal interneuron differentiation|inhibition of spinal cord association neuron differentiation|inhibition of spinal cord dorsal interneuron differentiation|negative regulation of spinal cord dorsal interneuron differentiation http://purl.obolibrary.org/obo/GO_1902830 GO:1902831 biolink:BiologicalProcess positive regulation of spinal cord association neuron differentiation Any process that activates or increases the frequency, rate or extent of spinal cord association neuron differentiation. go.json activation of spinal cord association neuron differentiation|activation of spinal cord dorsal interneuron differentiation|positive regulation of spinal cord dorsal interneuron differentiation|up regulation of spinal cord association neuron differentiation|up regulation of spinal cord dorsal interneuron differentiation|up-regulation of spinal cord association neuron differentiation|up-regulation of spinal cord dorsal interneuron differentiation|upregulation of spinal cord association neuron differentiation|upregulation of spinal cord dorsal interneuron differentiation http://purl.obolibrary.org/obo/GO_1902831 GO:0048760 biolink:BiologicalProcess plant parenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure. go.json parenchymal cell differentiation http://purl.obolibrary.org/obo/GO_0048760 GO:0048761 biolink:BiologicalProcess collenchyma cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles. go.json http://purl.obolibrary.org/obo/GO_0048761 GO:0048773 biolink:BiologicalProcess erythrophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance. go.json erythrophore cell differentiation http://purl.obolibrary.org/obo/GO_0048773 GO:0048774 biolink:BiologicalProcess cyanophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes. go.json cyanophore cell differentiation http://purl.obolibrary.org/obo/GO_0048774 GO:1902849 biolink:BiologicalProcess positive regulation of neuronal signal transduction Any process that activates or increases the frequency, rate or extent of neuronal signal transduction. go.json activation of neuronal signal transduction|up regulation of neuronal signal transduction|up-regulation of neuronal signal transduction|upregulation of neuronal signal transduction http://purl.obolibrary.org/obo/GO_1902849 GO:0048775 biolink:BiologicalProcess regulation of leucophore differentiation Any process that modulates the frequency, rate or extent of leucophore differentiation. go.json http://purl.obolibrary.org/obo/GO_0048775 GO:0048776 biolink:BiologicalProcess negative regulation of leucophore differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation. go.json down regulation of leucophore differentiation|down-regulation of leucophore differentiation|downregulation of leucophore differentiation|inhibition of leucophore differentiation http://purl.obolibrary.org/obo/GO_0048776 GO:1902847 biolink:BiologicalProcess regulation of neuronal signal transduction Any process that modulates the frequency, rate or extent of neuronal signal transduction. go.json http://purl.obolibrary.org/obo/GO_1902847 GO:0048777 biolink:BiologicalProcess positive regulation of leucophore differentiation Any process that activates or increases the frequency, rate or extent of leucophore differentiation. go.json activation of leucophore differentiation|stimulation of leucophore differentiation|up regulation of leucophore differentiation|up-regulation of leucophore differentiation|upregulation of leucophore differentiation http://purl.obolibrary.org/obo/GO_0048777 GO:1902848 biolink:BiologicalProcess negative regulation of neuronal signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of neuronal signal transduction. go.json down regulation of neuronal signal transduction|down-regulation of neuronal signal transduction|downregulation of neuronal signal transduction|inhibition of neuronal signal transduction http://purl.obolibrary.org/obo/GO_1902848 GO:0048778 biolink:BiologicalProcess regulation of erythrophore differentiation Any process that modulates the frequency, rate or extent of erythrophore differentiation. go.json http://purl.obolibrary.org/obo/GO_0048778 GO:1902845 biolink:BiologicalProcess negative regulation of mitotic spindle elongation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation. go.json down regulation of mitotic spindle elongation|down regulation of spindle elongation during mitosis|down-regulation of mitotic spindle elongation|down-regulation of spindle elongation during mitosis|downregulation of mitotic spindle elongation|downregulation of spindle elongation during mitosis|inhibition of mitotic spindle elongation|inhibition of spindle elongation during mitosis|negative regulation of spindle elongation during mitosis http://purl.obolibrary.org/obo/GO_1902845 GO:0048779 biolink:BiologicalProcess negative regulation of erythrophore differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation. go.json down regulation of erythrophore differentiation|down-regulation of erythrophore differentiation|downregulation of erythrophore differentiation|inhibition of erythrophore differentiation http://purl.obolibrary.org/obo/GO_0048779 GO:1902846 biolink:BiologicalProcess positive regulation of mitotic spindle elongation Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation. go.json activation of mitotic spindle elongation|activation of spindle elongation during mitosis|positive regulation of spindle elongation during mitosis|up regulation of mitotic spindle elongation|up regulation of spindle elongation during mitosis|up-regulation of mitotic spindle elongation|up-regulation of spindle elongation during mitosis|upregulation of mitotic spindle elongation|upregulation of spindle elongation during mitosis http://purl.obolibrary.org/obo/GO_1902846 GO:1902843 biolink:BiologicalProcess positive regulation of netrin-activated signaling pathway Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway. go.json activation of netrin signaling pathway|activation of netrin-activated signal transduction pathway|activation of netrin-activated signaling pathway|activation of netrin-activated signalling pathway|activation of netrin-mediated signaling pathway|positive regulation of netrin signaling pathway|positive regulation of netrin-activated signal transduction pathway|positive regulation of netrin-activated signalling pathway|positive regulation of netrin-mediated signaling pathway|up regulation of netrin signaling pathway|up regulation of netrin-activated signal transduction pathway|up regulation of netrin-activated signaling pathway|up regulation of netrin-activated signalling pathway|up regulation of netrin-mediated signaling pathway|up-regulation of netrin signaling pathway|up-regulation of netrin-activated signal transduction pathway|up-regulation of netrin-activated signaling pathway|up-regulation of netrin-activated signalling pathway|up-regulation of netrin-mediated signaling pathway|upregulation of netrin signaling pathway|upregulation of netrin-activated signal transduction pathway|upregulation of netrin-activated signaling pathway|upregulation of netrin-activated signalling pathway|upregulation of netrin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902843 GO:1902844 biolink:BiologicalProcess positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway A negative regulation of canonical Wnt signaling pathway that results in positive regulation of spinal cord association neuron differentiation. go.json activation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway|activation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway|positive regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway|up regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway|up regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway|up-regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway|up-regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway|upregulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway|upregulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway http://purl.obolibrary.org/obo/GO_1902844 GO:1902841 biolink:BiologicalProcess regulation of netrin-activated signaling pathway Any process that modulates the frequency, rate or extent of netrin-activated signaling pathway. go.json regulation of netrin signaling pathway|regulation of netrin-activated signal transduction pathway|regulation of netrin-activated signalling pathway|regulation of netrin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902841 GO:1902842 biolink:BiologicalProcess negative regulation of netrin-activated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway. go.json down regulation of netrin signaling pathway|down regulation of netrin-activated signal transduction pathway|down regulation of netrin-activated signaling pathway|down regulation of netrin-activated signalling pathway|down regulation of netrin-mediated signaling pathway|down-regulation of netrin signaling pathway|down-regulation of netrin-activated signal transduction pathway|down-regulation of netrin-activated signaling pathway|down-regulation of netrin-activated signalling pathway|down-regulation of netrin-mediated signaling pathway|downregulation of netrin signaling pathway|downregulation of netrin-activated signal transduction pathway|downregulation of netrin-activated signaling pathway|downregulation of netrin-activated signalling pathway|downregulation of netrin-mediated signaling pathway|inhibition of netrin signaling pathway|inhibition of netrin-activated signal transduction pathway|inhibition of netrin-activated signaling pathway|inhibition of netrin-activated signalling pathway|inhibition of netrin-mediated signaling pathway|negative regulation of netrin signaling pathway|negative regulation of netrin-activated signal transduction pathway|negative regulation of netrin-activated signalling pathway|negative regulation of netrin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902842 GO:1902840 biolink:BiologicalProcess positive regulation of nuclear migration along microtubule Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. go.json activation of microtubule cytoskeleton-dependent nuclear positioning|activation of microtubule cytoskeleton-dependent nucleus positioning|activation of microtubule-dependent nuclear positioning|activation of microtubule-dependent nucleus positioning|activation of microtubule-mediated nuclear migration|activation of nuclear migration along microtubule|activation of nuclear migration, microtubule-mediated|activation of transport of nucleus by microtubules|activation of transport of nucleus, microtubule-mediated|positive regulation of microtubule cytoskeleton-dependent nuclear positioning|positive regulation of microtubule cytoskeleton-dependent nucleus positioning|positive regulation of microtubule-dependent nuclear positioning|positive regulation of microtubule-dependent nucleus positioning|positive regulation of microtubule-mediated nuclear migration|positive regulation of nuclear migration, microtubule-mediated|positive regulation of transport of nucleus by microtubules|positive regulation of transport of nucleus, microtubule-mediated|up regulation of microtubule cytoskeleton-dependent nuclear positioning|up regulation of microtubule cytoskeleton-dependent nucleus positioning|up regulation of microtubule-dependent nuclear positioning|up regulation of microtubule-dependent nucleus positioning|up regulation of microtubule-mediated nuclear migration|up regulation of nuclear migration along microtubule|up regulation of nuclear migration, microtubule-mediated|up regulation of transport of nucleus by microtubules|up regulation of transport of nucleus, microtubule-mediated|up-regulation of microtubule cytoskeleton-dependent nuclear positioning|up-regulation of microtubule cytoskeleton-dependent nucleus positioning|up-regulation of microtubule-dependent nuclear positioning|up-regulation of microtubule-dependent nucleus positioning|up-regulation of microtubule-mediated nuclear migration|up-regulation of nuclear migration along microtubule|up-regulation of nuclear migration, microtubule-mediated|up-regulation of transport of nucleus by microtubules|up-regulation of transport of nucleus, microtubule-mediated|upregulation of microtubule cytoskeleton-dependent nuclear positioning|upregulation of microtubule cytoskeleton-dependent nucleus positioning|upregulation of microtubule-dependent nuclear positioning|upregulation of microtubule-dependent nucleus positioning|upregulation of microtubule-mediated nuclear migration|upregulation of nuclear migration along microtubule|upregulation of nuclear migration, microtubule-mediated|upregulation of transport of nucleus by microtubules|upregulation of transport of nucleus, microtubule-mediated http://purl.obolibrary.org/obo/GO_1902840 GO:0048770 biolink:CellularComponent pigment granule A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. go.json http://purl.obolibrary.org/obo/GO_0048770 GO:0048771 biolink:BiologicalProcess tissue remodeling The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. go.json tissue remodelling http://purl.obolibrary.org/obo/GO_0048771 goslim_pir GO:0048772 biolink:BiologicalProcess leucophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance. go.json leucophore cell differentiation http://purl.obolibrary.org/obo/GO_0048772 GO:0048784 biolink:BiologicalProcess pigment biosynthetic process involved in pigment granule maturation The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. go.json pigment biosynthetic process during pigment granule maturation http://purl.obolibrary.org/obo/GO_0048784 GO:0048785 biolink:BiologicalProcess hatching gland development The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process. go.json http://purl.obolibrary.org/obo/GO_0048785 GO:0048786 biolink:CellularComponent presynaptic active zone A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. NIF_Subcellular:sao792027222 go.json pre-synaptic active zone|pre-synaptic active zone component|presynaptic specialization http://purl.obolibrary.org/obo/GO_0048786 goslim_synapse GO:0048787 biolink:CellularComponent presynaptic active zone membrane The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. NIF_Subcellular:sao2038461087 go.json active zone plasma membrane|active zone pre-synaptic plasma membrane|active zone presynaptic plasma membrane|pre-synaptic active zone membrane http://purl.obolibrary.org/obo/GO_0048787 goslim_synapse GO:0048788 biolink:CellularComponent cytoskeleton of presynaptic active zone The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites. NIF_Subcellular:sao1470121605 go.json CAZ|T-bar|T-bar ribbon|active zone cytomatrix|pre-synaptic cytoskeletal matrix assembled at active zones|pre-synaptic dense body|pre-synaptic ribbon|presynaptic cytomatrix assembled at active zones|presynaptic cytoskeletal matrix|presynaptic cytoskeletal matrix assembled at active zones|presynaptic dense body|presynaptic ribbon|ribbon|synaptic ribbon http://purl.obolibrary.org/obo/GO_0048788 GO:1902858 biolink:BiologicalProcess propionyl-CoA metabolic process The chemical reactions and pathways involving propionyl-CoA. go.json propionyl-CoA metabolism http://purl.obolibrary.org/obo/GO_1902858 GO:1902859 biolink:BiologicalProcess propionyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of propionyl-CoA. go.json propionyl-CoA breakdown|propionyl-CoA catabolism|propionyl-CoA degradation http://purl.obolibrary.org/obo/GO_1902859 GO:0048789 biolink:BiologicalProcess cytoskeletal matrix organization at active zone The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane. go.json cytoskeletal matrix organisation at active zone http://purl.obolibrary.org/obo/GO_0048789 GO:1902856 biolink:BiologicalProcess negative regulation of non-motile cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly. go.json down regulation of immotile primary cilium assembly|down regulation of nonmotile primary cilia assembly|down regulation of nonmotile primary cilium assembly|down regulation of sensory cilium assembly|down regulation of sensory cilium biogenesis|down-regulation of immotile primary cilium assembly|down-regulation of nonmotile primary cilia assembly|down-regulation of nonmotile primary cilium assembly|down-regulation of sensory cilium assembly|down-regulation of sensory cilium biogenesis|downregulation of immotile primary cilium assembly|downregulation of nonmotile primary cilia assembly|downregulation of nonmotile primary cilium assembly|downregulation of sensory cilium assembly|downregulation of sensory cilium biogenesis|inhibition of immotile primary cilium assembly|inhibition of nonmotile primary cilia assembly|inhibition of nonmotile primary cilium assembly|inhibition of sensory cilium assembly|inhibition of sensory cilium biogenesis|negative regulation of immotile primary cilium assembly|negative regulation of nonmotile primary cilia assembly|negative regulation of nonmotile primary cilium assembly|negative regulation of sensory cilium assembly|negative regulation of sensory cilium biogenesis http://purl.obolibrary.org/obo/GO_1902856 GO:1902857 biolink:BiologicalProcess positive regulation of non-motile cilium assembly Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly. go.json activation of immotile primary cilium assembly|activation of nonmotile primary cilia assembly|activation of nonmotile primary cilium assembly|activation of sensory cilium assembly|activation of sensory cilium biogenesis|positive regulation of immotile primary cilium assembly|positive regulation of nonmotile primary cilia assembly|positive regulation of nonmotile primary cilium assembly|positive regulation of sensory cilium assembly|positive regulation of sensory cilium biogenesis|up regulation of immotile primary cilium assembly|up regulation of nonmotile primary cilia assembly|up regulation of nonmotile primary cilium assembly|up regulation of sensory cilium assembly|up regulation of sensory cilium biogenesis|up-regulation of immotile primary cilium assembly|up-regulation of nonmotile primary cilia assembly|up-regulation of nonmotile primary cilium assembly|up-regulation of sensory cilium assembly|up-regulation of sensory cilium biogenesis|upregulation of immotile primary cilium assembly|upregulation of nonmotile primary cilia assembly|upregulation of nonmotile primary cilium assembly|upregulation of sensory cilium assembly|upregulation of sensory cilium biogenesis http://purl.obolibrary.org/obo/GO_1902857 GO:1902854 biolink:BiologicalProcess positive regulation of nuclear migration during mitotic telophase Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase. go.json activation of nuclear migration during mitotic telophase|up regulation of nuclear migration during mitotic telophase|up-regulation of nuclear migration during mitotic telophase|upregulation of nuclear migration during mitotic telophase http://purl.obolibrary.org/obo/GO_1902854 GO:1902855 biolink:BiologicalProcess regulation of non-motile cilium assembly Any process that modulates the frequency, rate or extent of non-motile cilium assembly. go.json regulation of immotile primary cilium assembly|regulation of nonmotile primary cilia assembly|regulation of nonmotile primary cilium assembly|regulation of sensory cilium assembly|regulation of sensory cilium biogenesis http://purl.obolibrary.org/obo/GO_1902855 GO:1902852 biolink:BiologicalProcess regulation of nuclear migration during mitotic telophase Any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase. go.json http://purl.obolibrary.org/obo/GO_1902852 GO:1902853 biolink:BiologicalProcess negative regulation of nuclear migration during mitotic telophase Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase. go.json down regulation of nuclear migration during mitotic telophase|down-regulation of nuclear migration during mitotic telophase|downregulation of nuclear migration during mitotic telophase|inhibition of nuclear migration during mitotic telophase http://purl.obolibrary.org/obo/GO_1902853 GO:1902850 biolink:BiologicalProcess microtubule cytoskeleton organization involved in mitosis Any microtubule cytoskeleton organization that is involved in mitosis. go.json microtubule cytoskeleton organisation involved in mitosis|microtubule cytoskeleton organization and biogenesis involved in mitosis|microtubule dynamics involved in mitosis http://purl.obolibrary.org/obo/GO_1902850 GO:0048780 biolink:BiologicalProcess positive regulation of erythrophore differentiation Any process that activates or increases the frequency, rate or extent of erythrophore differentiation. go.json activation of erythrophore differentiation|stimulation of erythrophore differentiation|up regulation of erythrophore differentiation|up-regulation of erythrophore differentiation|upregulation of erythrophore differentiation http://purl.obolibrary.org/obo/GO_0048780 GO:0048781 biolink:BiologicalProcess regulation of cyanophore differentiation Any process that modulates the frequency, rate or extent of cyanophore differentiation. go.json http://purl.obolibrary.org/obo/GO_0048781 GO:0048782 biolink:BiologicalProcess negative regulation of cyanophore differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation. go.json down regulation of cyanophore differentiation|down-regulation of cyanophore differentiation|downregulation of cyanophore differentiation|inhibition of cyanophore differentiation http://purl.obolibrary.org/obo/GO_0048782 GO:0048783 biolink:BiologicalProcess positive regulation of cyanophore differentiation Any process that activates or increases the frequency, rate or extent of cyanophore differentiation. go.json activation of cyanophore differentiation|stimulation of cyanophore differentiation|up regulation of cyanophore differentiation|up-regulation of cyanophore differentiation|upregulation of cyanophore differentiation http://purl.obolibrary.org/obo/GO_0048783 GO:0097719 biolink:BiologicalProcess neural tissue regeneration The regrowth of neural tissue following its loss or destruction. go.json neuroregeneration http://purl.obolibrary.org/obo/GO_0097719 GO:0097717 biolink:BiologicalProcess copper ion transport across blood-cerebrospinal fluid barrier The directed movement of copper (Cu) ions passing through the blood-cerebrospinal fluid barrier. go.json copper ion transport across BCB|copper ion transport across BCSFB|copper ion transport across blood-CSF barrier|copper ion transport across blood/CSF barrier|copper ion transport across blood/cerebrospinal fluid barrier http://purl.obolibrary.org/obo/GO_0097717 GO:0097718 biolink:MolecularActivity disordered domain specific binding Binding to a disordered domain of a protein. go.json disordered protein domain specific binding http://purl.obolibrary.org/obo/GO_0097718 GO:0097715 biolink:BiologicalProcess cellular response to viscosity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. go.json http://purl.obolibrary.org/obo/GO_0097715 GO:0097716 biolink:BiologicalProcess copper ion transport across blood-brain barrier The directed movement of copper (Cu) ions passing through the blood-brain barrier. go.json copper ion transport across BBB http://purl.obolibrary.org/obo/GO_0097716 GO:0097713 biolink:MolecularActivity dolichol-phosphate-mannose synthase regulator activity Binds to and modulates the activity of dolichol-phosphate-mannose synthase. go.json http://purl.obolibrary.org/obo/GO_0097713 GO:0097714 biolink:BiologicalProcess response to viscosity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. go.json http://purl.obolibrary.org/obo/GO_0097714 GO:0097711 biolink:BiologicalProcess ciliary basal body-plasma membrane docking The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. Reactome:R-HSA-5620912.1 go.json anchoring of the basal body to the plasma membrane|ciliary basal body docking http://purl.obolibrary.org/obo/GO_0097711 GO:0097712 biolink:BiologicalProcess vesicle targeting, trans-Golgi to periciliary membrane compartment The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. go.json http://purl.obolibrary.org/obo/GO_0097712 GO:0097710 biolink:CellularComponent viral terminase, small subunit The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit. go.json virus terminase, small subunit http://purl.obolibrary.org/obo/GO_0097710 GO:0048795 biolink:BiologicalProcess swim bladder morphogenesis The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. go.json gas bladder morphogenesis http://purl.obolibrary.org/obo/GO_0048795 GO:0048796 biolink:BiologicalProcess swim bladder maturation A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. go.json gas bladder maturation http://purl.obolibrary.org/obo/GO_0048796 GO:0048797 biolink:BiologicalProcess swim bladder formation The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. go.json gas bladder biosynthesis|gas bladder formation http://purl.obolibrary.org/obo/GO_0048797 GO:0048798 biolink:BiologicalProcess swim bladder inflation The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. go.json gas bladder inflation http://purl.obolibrary.org/obo/GO_0048798 GO:1902869 biolink:BiologicalProcess regulation of amacrine cell differentiation Any process that modulates the frequency, rate or extent of amacrine cell differentiation. go.json regulation of amacrine neuron differentiation http://purl.obolibrary.org/obo/GO_1902869 GO:0048799 biolink:BiologicalProcess animal organ maturation A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. go.json http://purl.obolibrary.org/obo/GO_0048799 GO:1902867 biolink:BiologicalProcess negative regulation of retina development in camera-type eye Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. go.json down regulation of retina development in camera-style eye|down regulation of retina development in camera-type eye|down regulation of retinal development|down-regulation of retina development in camera-style eye|down-regulation of retina development in camera-type eye|down-regulation of retinal development|downregulation of retina development in camera-style eye|downregulation of retina development in camera-type eye|downregulation of retinal development|inhibition of retina development in camera-style eye|inhibition of retina development in camera-type eye|inhibition of retinal development|negative regulation of retina development in camera-style eye|negative regulation of retinal development http://purl.obolibrary.org/obo/GO_1902867 GO:1902868 biolink:BiologicalProcess positive regulation of retina development in camera-type eye Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. go.json activation of retina development in camera-style eye|activation of retina development in camera-type eye|activation of retinal development|positive regulation of retina development in camera-style eye|positive regulation of retinal development|up regulation of retina development in camera-style eye|up regulation of retina development in camera-type eye|up regulation of retinal development|up-regulation of retina development in camera-style eye|up-regulation of retina development in camera-type eye|up-regulation of retinal development|upregulation of retina development in camera-style eye|upregulation of retina development in camera-type eye|upregulation of retinal development http://purl.obolibrary.org/obo/GO_1902868 GO:1902865 biolink:BiologicalProcess positive regulation of embryonic camera-type eye development Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. go.json activation of embryonic camera-type eye development|activation of embryonic eye development|positive regulation of embryonic eye development|up regulation of embryonic camera-type eye development|up regulation of embryonic eye development|up-regulation of embryonic camera-type eye development|up-regulation of embryonic eye development|upregulation of embryonic camera-type eye development|upregulation of embryonic eye development http://purl.obolibrary.org/obo/GO_1902865 GO:1902866 biolink:BiologicalProcess regulation of retina development in camera-type eye Any process that modulates the frequency, rate or extent of retina development in camera-type eye. go.json regulation of retina development in camera-style eye|regulation of retinal development http://purl.obolibrary.org/obo/GO_1902866 GO:1902863 biolink:BiologicalProcess regulation of embryonic camera-type eye development Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. go.json regulation of embryonic eye development http://purl.obolibrary.org/obo/GO_1902863 GO:1902864 biolink:BiologicalProcess negative regulation of embryonic camera-type eye development Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. go.json down regulation of embryonic camera-type eye development|down regulation of embryonic eye development|down-regulation of embryonic camera-type eye development|down-regulation of embryonic eye development|downregulation of embryonic camera-type eye development|downregulation of embryonic eye development|inhibition of embryonic camera-type eye development|inhibition of embryonic eye development|negative regulation of embryonic eye development http://purl.obolibrary.org/obo/GO_1902864 GO:0048790 biolink:BiologicalProcess maintenance of presynaptic active zone structure A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. go.json maintenance of pre-synaptic active zone structure http://purl.obolibrary.org/obo/GO_0048790 goslim_synapse GO:1902861 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902861 GO:0048791 biolink:BiologicalProcess calcium ion-regulated exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. go.json http://purl.obolibrary.org/obo/GO_0048791 GO:1902862 biolink:BiologicalProcess obsolete glycerol catabolic process to glycerone phosphate OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycerol to glycerone phosphate. go.json glycerol breakdown to glycerone phosphate|glycerol catabolic process to glycerone phosphate|glycerol catabolism to glycerone phosphate|glycerol degradation to glycerone phosphate True http://purl.obolibrary.org/obo/GO_1902862 GO:0048792 biolink:BiologicalProcess spontaneous exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell. go.json spontaneous synaptic vesicle exocytosis http://purl.obolibrary.org/obo/GO_0048792 GO:0048793 biolink:BiologicalProcess pronephros development The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. go.json pronephric kidney development http://purl.obolibrary.org/obo/GO_0048793 GO:1902860 biolink:BiologicalProcess propionyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of propionyl-CoA. go.json propionyl-CoA anabolism|propionyl-CoA biosynthesis|propionyl-CoA formation|propionyl-CoA synthesis http://purl.obolibrary.org/obo/GO_1902860 GO:0048794 biolink:BiologicalProcess swim bladder development The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. go.json gas bladder development http://purl.obolibrary.org/obo/GO_0048794 GO:0097728 biolink:CellularComponent 9+0 motile cilium A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). go.json motile 9+0 cilium|nodal cilium http://purl.obolibrary.org/obo/GO_0097728 GO:0097729 biolink:CellularComponent 9+2 motile cilium A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). go.json conventional motile cilium|motile 9+2 cilium|sperm flagellum http://purl.obolibrary.org/obo/GO_0097729 GO:0097726 biolink:MolecularActivity LEM domain binding Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). go.json LAP2, emerin, MAN1 domain binding|lamina-associated polypeptide, emerin, MAN1 domain binding http://purl.obolibrary.org/obo/GO_0097726 GO:0097727 biolink:CellularComponent blepharoplast An intracellular non-membrane-bounded organelle found in multi-ciliated sperm cells of some primitive land plants, and consisting of many radially arranged ninefold symmetric cylinders. The blepharoplast is involved in de novo formation of multiple centrioles; it enlarges and then disintegrates into many procentrioles, which elongate and ultimately nucleate cilia on the surface of the sperm cell. go.json http://purl.obolibrary.org/obo/GO_0097727 GO:0097724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097724 GO:0097725 biolink:BiologicalProcess obsolete histone H3-K79 dimethylation OBSOLETE. The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone. go.json histone H3 K79 dimethylation|histone lysine H3 K79 dimethylation True http://purl.obolibrary.org/obo/GO_0097725 GO:0097722 biolink:BiologicalProcess sperm motility Any process involved in the controlled movement of a sperm cell. go.json sperm movement http://purl.obolibrary.org/obo/GO_0097722 gocheck_do_not_annotate GO:0097723 biolink:BiologicalProcess amoeboid sperm motility Any process involved in the controlled movement of an amoeboid sperm cell. go.json ameboid sperm motility|ameboid sperm movement|amoeboid sperm movement http://purl.obolibrary.org/obo/GO_0097723 GO:0097720 biolink:BiologicalProcess calcineurin-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. go.json calcineurin signaling|calcineurin-mediated signalling http://purl.obolibrary.org/obo/GO_0097720 GO:0097721 biolink:CellularComponent ciliary vesicle A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle. go.json CV|primary ciliary vesicle http://purl.obolibrary.org/obo/GO_0097721 GO:1902878 biolink:BiologicalProcess obsolete regulation of BMP signaling pathway involved in spinal cord association neuron specification OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification. go.json regulation of BMP signalling pathway involved in spinal cord association neuron specification|regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification True http://purl.obolibrary.org/obo/GO_1902878 GO:1902879 biolink:BiologicalProcess obsolete negative regulation of BMP signaling pathway involved in spinal cord association neuron specification OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification. go.json down regulation of BMP signaling pathway involved in spinal cord association neuron specification|down regulation of BMP signalling pathway involved in spinal cord association neuron specification|down regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|down regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|down-regulation of BMP signaling pathway involved in spinal cord association neuron specification|down-regulation of BMP signalling pathway involved in spinal cord association neuron specification|down-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|down-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|downregulation of BMP signaling pathway involved in spinal cord association neuron specification|downregulation of BMP signalling pathway involved in spinal cord association neuron specification|downregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|downregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|inhibition of BMP signaling pathway involved in spinal cord association neuron specification|inhibition of BMP signalling pathway involved in spinal cord association neuron specification|inhibition of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|inhibition of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|negative regulation of BMP signalling pathway involved in spinal cord association neuron specification|negative regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|negative regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification True http://purl.obolibrary.org/obo/GO_1902879 GO:1902876 biolink:BiologicalProcess negative regulation of embryonic pattern specification Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification. go.json down regulation of embryonic pattern specification|down regulation of ventral/lateral system|down-regulation of embryonic pattern specification|down-regulation of ventral/lateral system|downregulation of embryonic pattern specification|downregulation of ventral/lateral system|inhibition of embryonic pattern specification|inhibition of ventral/lateral system|negative regulation of ventral/lateral system http://purl.obolibrary.org/obo/GO_1902876 GO:1902877 biolink:BiologicalProcess positive regulation of embryonic pattern specification Any process that activates or increases the frequency, rate or extent of embryonic pattern specification. go.json activation of embryonic pattern specification|activation of ventral/lateral system|positive regulation of ventral/lateral system|up regulation of embryonic pattern specification|up regulation of ventral/lateral system|up-regulation of embryonic pattern specification|up-regulation of ventral/lateral system|upregulation of embryonic pattern specification|upregulation of ventral/lateral system http://purl.obolibrary.org/obo/GO_1902877 GO:1902874 biolink:BiologicalProcess positive regulation of horizontal cell localization Any process that activates or increases the frequency, rate or extent of horizontal cell localization. go.json activation of horizontal cell localisation|activation of horizontal cell localization|activation of horizontal cell positioning|activation of laminar positioning of retinal horizontal cell|activation of retinal horizontal cell positioning|positive regulation of horizontal cell localisation|positive regulation of horizontal cell positioning|positive regulation of laminar positioning of retinal horizontal cell|positive regulation of retinal horizontal cell positioning|up regulation of horizontal cell localisation|up regulation of horizontal cell localization|up regulation of horizontal cell positioning|up regulation of laminar positioning of retinal horizontal cell|up regulation of retinal horizontal cell positioning|up-regulation of horizontal cell localisation|up-regulation of horizontal cell localization|up-regulation of horizontal cell positioning|up-regulation of laminar positioning of retinal horizontal cell|up-regulation of retinal horizontal cell positioning|upregulation of horizontal cell localisation|upregulation of horizontal cell localization|upregulation of horizontal cell positioning|upregulation of laminar positioning of retinal horizontal cell|upregulation of retinal horizontal cell positioning http://purl.obolibrary.org/obo/GO_1902874 GO:1902875 biolink:BiologicalProcess regulation of embryonic pattern specification Any process that modulates the frequency, rate or extent of embryonic pattern specification. go.json regulation of embryonic pattern biosynthesis|regulation of embryonic pattern formation|regulation of ventral/lateral system http://purl.obolibrary.org/obo/GO_1902875 GO:1902872 biolink:BiologicalProcess regulation of horizontal cell localization Any process that modulates the frequency, rate or extent of horizontal cell localization. go.json regulation of horizontal cell localisation|regulation of horizontal cell positioning|regulation of laminar positioning of retinal horizontal cell|regulation of retinal horizontal cell positioning http://purl.obolibrary.org/obo/GO_1902872 GO:1902873 biolink:BiologicalProcess negative regulation of horizontal cell localization Any process that stops, prevents or reduces the frequency, rate or extent of horizontal cell localization. go.json down regulation of horizontal cell localisation|down regulation of horizontal cell localization|down regulation of horizontal cell positioning|down regulation of laminar positioning of retinal horizontal cell|down regulation of retinal horizontal cell positioning|down-regulation of horizontal cell localisation|down-regulation of horizontal cell localization|down-regulation of horizontal cell positioning|down-regulation of laminar positioning of retinal horizontal cell|down-regulation of retinal horizontal cell positioning|downregulation of horizontal cell localisation|downregulation of horizontal cell localization|downregulation of horizontal cell positioning|downregulation of laminar positioning of retinal horizontal cell|downregulation of retinal horizontal cell positioning|inhibition of horizontal cell localisation|inhibition of horizontal cell localization|inhibition of horizontal cell positioning|inhibition of laminar positioning of retinal horizontal cell|inhibition of retinal horizontal cell positioning|negative regulation of horizontal cell localisation|negative regulation of horizontal cell positioning|negative regulation of laminar positioning of retinal horizontal cell|negative regulation of retinal horizontal cell positioning http://purl.obolibrary.org/obo/GO_1902873 GO:1902870 biolink:BiologicalProcess negative regulation of amacrine cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation. go.json down regulation of amacrine cell differentiation|down regulation of amacrine neuron differentiation|down-regulation of amacrine cell differentiation|down-regulation of amacrine neuron differentiation|downregulation of amacrine cell differentiation|downregulation of amacrine neuron differentiation|inhibition of amacrine cell differentiation|inhibition of amacrine neuron differentiation|negative regulation of amacrine neuron differentiation http://purl.obolibrary.org/obo/GO_1902870 GO:1902871 biolink:BiologicalProcess positive regulation of amacrine cell differentiation Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation. go.json activation of amacrine cell differentiation|activation of amacrine neuron differentiation|positive regulation of amacrine neuron differentiation|up regulation of amacrine cell differentiation|up regulation of amacrine neuron differentiation|up-regulation of amacrine cell differentiation|up-regulation of amacrine neuron differentiation|upregulation of amacrine cell differentiation|upregulation of amacrine neuron differentiation http://purl.obolibrary.org/obo/GO_1902871 GO:0034198 biolink:BiologicalProcess cellular response to amino acid starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. go.json GAAC response|general amino acid control response http://purl.obolibrary.org/obo/GO_0034198 GO:0034199 biolink:BiologicalProcess activation of protein kinase A activity Any process that initiates the activity of the inactive enzyme protein kinase A. go.json protein kinase A activation http://purl.obolibrary.org/obo/GO_0034199 gocheck_do_not_annotate GO:1902880 biolink:BiologicalProcess obsolete positive regulation of BMP signaling pathway involved in spinal cord association neuron specification OBSOLETE. Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification. go.json activation of BMP signaling pathway involved in spinal cord association neuron specification|activation of BMP signalling pathway involved in spinal cord association neuron specification|activation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|activation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|positive regulation of BMP signalling pathway involved in spinal cord association neuron specification|positive regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|positive regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|up regulation of BMP signaling pathway involved in spinal cord association neuron specification|up regulation of BMP signalling pathway involved in spinal cord association neuron specification|up regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|up regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|up-regulation of BMP signaling pathway involved in spinal cord association neuron specification|up-regulation of BMP signalling pathway involved in spinal cord association neuron specification|up-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|up-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification|upregulation of BMP signaling pathway involved in spinal cord association neuron specification|upregulation of BMP signalling pathway involved in spinal cord association neuron specification|upregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification|upregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification True http://purl.obolibrary.org/obo/GO_1902880 GO:0034190 biolink:MolecularActivity apolipoprotein receptor binding Binding to an apolipoprotein receptor. go.json http://purl.obolibrary.org/obo/GO_0034190 GO:0034191 biolink:MolecularActivity apolipoprotein A-I receptor binding Binding to an apolipoprotein A-I receptor. go.json http://purl.obolibrary.org/obo/GO_0034191 GO:0034192 biolink:BiologicalProcess D-galactonate metabolic process The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid. go.json D-galactonate metabolism http://purl.obolibrary.org/obo/GO_0034192 GO:0034193 biolink:BiologicalProcess L-galactonate metabolic process The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid. go.json L-galactonate metabolism http://purl.obolibrary.org/obo/GO_0034193 GO:0034194 biolink:BiologicalProcess D-galactonate catabolic process The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid. MetaCyc:GALACTCAT-PWY go.json D-galactonate breakdown|D-galactonate catabolism|D-galactonate degradation http://purl.obolibrary.org/obo/GO_0034194 GO:0034195 biolink:BiologicalProcess L-galactonate catabolic process The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid. MetaCyc:GALACTCAT-PWY go.json L-galactonate breakdown|L-galactonate catabolism|L-galactonate degradation http://purl.obolibrary.org/obo/GO_0034195 GO:0034196 biolink:BiologicalProcess acylglycerol transport The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids. go.json glyceride transport http://purl.obolibrary.org/obo/GO_0034196 GO:0034197 biolink:BiologicalProcess triglyceride transport The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. go.json triacylglycerol transport http://purl.obolibrary.org/obo/GO_0034197 GO:1902889 biolink:BiologicalProcess protein localization to spindle microtubule A process in which a protein is transported to, or maintained in, a location within a spindle microtubule. go.json protein localisation in spindle microtubule|protein localisation to spindle microtubule|protein localization in spindle microtubule http://purl.obolibrary.org/obo/GO_1902889 GO:1902887 biolink:BiologicalProcess obsolete positive regulation of proteasome-activating ATPase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of proteasome-activating ATPase activity. go.json activation of ATPase involved in positive regulation of proteasomal protein catabolic process|activation of proteasomal ATPase activity|activation of proteasome channel gating activity|activation of proteasome channel opening activity|activation of proteasome-activating ATPase activity|positive regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|positive regulation of proteasomal ATPase activity|positive regulation of proteasome channel gating activity|positive regulation of proteasome channel opening activity|up regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|up regulation of proteasomal ATPase activity|up regulation of proteasome channel gating activity|up regulation of proteasome channel opening activity|up regulation of proteasome-activating ATPase activity|up-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|up-regulation of proteasomal ATPase activity|up-regulation of proteasome channel gating activity|up-regulation of proteasome channel opening activity|up-regulation of proteasome-activating ATPase activity|upregulation of ATPase involved in positive regulation of proteasomal protein catabolic process|upregulation of proteasomal ATPase activity|upregulation of proteasome channel gating activity|upregulation of proteasome channel opening activity|upregulation of proteasome-activating ATPase activity True http://purl.obolibrary.org/obo/GO_1902887 GO:1902888 biolink:BiologicalProcess protein localization to astral microtubule A process in which a protein is transported to, or maintained in, a location within an astral microtubule. go.json protein localisation in astral microtubule|protein localisation to astral microtubule|protein localization in astral microtubule http://purl.obolibrary.org/obo/GO_1902888 GO:1902885 biolink:BiologicalProcess obsolete regulation of proteasome-activating ATPase activity OBSOLETE. Any process that modulates the frequency, rate or extent of proteasome-activating ATPase activity. go.json regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|regulation of proteasomal ATPase activity|regulation of proteasome channel gating activity|regulation of proteasome channel opening activity True http://purl.obolibrary.org/obo/GO_1902885 GO:1902886 biolink:BiologicalProcess obsolete negative regulation of proteasome-activating ATPase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of proteasome-activating ATPase activity. go.json down regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|down regulation of proteasomal ATPase activity|down regulation of proteasome channel gating activity|down regulation of proteasome channel opening activity|down regulation of proteasome-activating ATPase activity|down-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|down-regulation of proteasomal ATPase activity|down-regulation of proteasome channel gating activity|down-regulation of proteasome channel opening activity|down-regulation of proteasome-activating ATPase activity|downregulation of ATPase involved in positive regulation of proteasomal protein catabolic process|downregulation of proteasomal ATPase activity|downregulation of proteasome channel gating activity|downregulation of proteasome channel opening activity|downregulation of proteasome-activating ATPase activity|inhibition of ATPase involved in positive regulation of proteasomal protein catabolic process|inhibition of proteasomal ATPase activity|inhibition of proteasome channel gating activity|inhibition of proteasome channel opening activity|inhibition of proteasome-activating ATPase activity|negative regulation of ATPase involved in positive regulation of proteasomal protein catabolic process|negative regulation of proteasomal ATPase activity|negative regulation of proteasome channel gating activity|negative regulation of proteasome channel opening activity True http://purl.obolibrary.org/obo/GO_1902886 GO:1902883 biolink:BiologicalProcess negative regulation of response to oxidative stress Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. go.json down regulation of response to oxidative stress|down-regulation of response to oxidative stress|downregulation of response to oxidative stress|inhibition of response to oxidative stress http://purl.obolibrary.org/obo/GO_1902883 GO:1902884 biolink:BiologicalProcess positive regulation of response to oxidative stress Any process that activates or increases the frequency, rate or extent of response to oxidative stress. go.json activation of response to oxidative stress|up regulation of response to oxidative stress|up-regulation of response to oxidative stress|upregulation of response to oxidative stress http://purl.obolibrary.org/obo/GO_1902884 GO:1902881 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902881 GO:1902882 biolink:BiologicalProcess regulation of response to oxidative stress Any process that modulates the frequency, rate or extent of response to oxidative stress. go.json http://purl.obolibrary.org/obo/GO_1902882 GO:1902890 biolink:BiologicalProcess regulation of root hair elongation Any process that modulates the frequency, rate or extent of root hair elongation. go.json http://purl.obolibrary.org/obo/GO_1902890 GO:0034187 biolink:MolecularActivity obsolete apolipoprotein E binding OBSOLETE. Binding to apolipoprotein E. go.json apolipoprotein E binding True http://purl.obolibrary.org/obo/GO_0034187 GO:1902891 biolink:BiologicalProcess negative regulation of root hair elongation Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation. go.json down regulation of root hair elongation|down-regulation of root hair elongation|downregulation of root hair elongation|inhibition of root hair elongation http://purl.obolibrary.org/obo/GO_1902891 GO:0034188 biolink:MolecularActivity apolipoprotein A-I receptor activity Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0034188 GO:0034189 biolink:MolecularActivity very-low-density lipoprotein particle binding Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. go.json VLDL binding|very-low-density lipoprotein binding http://purl.obolibrary.org/obo/GO_0034189 GO:0097708 biolink:CellularComponent intracellular vesicle Any vesicle that is part of the intracellular region. go.json http://purl.obolibrary.org/obo/GO_0097708 GO:0097709 biolink:BiologicalProcess connective tissue replacement The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared. go.json http://purl.obolibrary.org/obo/GO_0097709 GO:0097706 biolink:BiologicalProcess vascular endothelial cell response to oscillatory fluid shear stress Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell. go.json blood vessel endothelial cell response to oscillatory fluid shear stress http://purl.obolibrary.org/obo/GO_0097706 GO:0097707 biolink:BiologicalProcess ferroptosis A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. go.json iron-dependent programmed cell death http://purl.obolibrary.org/obo/GO_0097707 GO:0097704 biolink:BiologicalProcess cellular response to oscillatory fluid shear stress Any response to oscillatory fluid shear stress that occurs at the level of a cell. go.json http://purl.obolibrary.org/obo/GO_0097704 GO:0097705 biolink:BiologicalProcess vascular endothelial cell response to pulsatile fluid shear stress Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell. go.json blood vessel endothelial cell response to pulsatile fluid shear stress http://purl.obolibrary.org/obo/GO_0097705 GO:0034180 biolink:BiologicalProcess negative regulation of toll-like receptor 13 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway. go.json negative regulation of TLR13 signaling pathway|negative regulation of toll-like receptor 13 signalling pathway http://purl.obolibrary.org/obo/GO_0034180 GO:0097702 biolink:BiologicalProcess response to oscillatory fluid shear stress Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis. go.json http://purl.obolibrary.org/obo/GO_0097702 GO:0034181 biolink:BiologicalProcess positive regulation of toll-like receptor 13 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway. go.json positive regulation of TLR13 signaling pathway|positive regulation of toll-like receptor 13 signalling pathway http://purl.obolibrary.org/obo/GO_0034181 GO:0097703 biolink:BiologicalProcess cellular response to pulsatile fluid shear stress Any response to pulsatile fluid shear stress that occurs at the level of a cell. go.json http://purl.obolibrary.org/obo/GO_0097703 GO:0034182 biolink:BiologicalProcess regulation of maintenance of mitotic sister chromatid cohesion Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034182 GO:0097700 biolink:BiologicalProcess vascular endothelial cell response to laminar fluid shear stress Any response to laminar fluid shear stress in a vascular endothelial cell. go.json blood vessel endothelial cell response to laminar fluid shear stress http://purl.obolibrary.org/obo/GO_0097700 GO:0034183 biolink:BiologicalProcess negative regulation of maintenance of mitotic sister chromatid cohesion Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034183 GO:0097701 biolink:BiologicalProcess response to pulsatile fluid shear stress Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects. go.json http://purl.obolibrary.org/obo/GO_0097701 GO:0034184 biolink:BiologicalProcess positive regulation of maintenance of mitotic sister chromatid cohesion Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034184 GO:0034185 biolink:MolecularActivity apolipoprotein binding Binding to an apolipoprotein, the protein component of a lipoprotein complex. go.json http://purl.obolibrary.org/obo/GO_0034185 GO:0034186 biolink:MolecularActivity apolipoprotein A-I binding Binding to apolipoprotein A-I. go.json http://purl.obolibrary.org/obo/GO_0034186 GO:0000960 biolink:BiologicalProcess regulation of mitochondrial RNA catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. go.json http://purl.obolibrary.org/obo/GO_0000960 GO:0000961 biolink:BiologicalProcess negative regulation of mitochondrial RNA catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. go.json http://purl.obolibrary.org/obo/GO_0000961 GO:0000962 biolink:BiologicalProcess positive regulation of mitochondrial RNA catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. go.json http://purl.obolibrary.org/obo/GO_0000962 GO:0000963 biolink:BiologicalProcess mitochondrial RNA processing The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0000963 GO:0048900 biolink:BiologicalProcess anterior lateral line neuromast primordium migration The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. go.json ALL neuromast primordium migration http://purl.obolibrary.org/obo/GO_0048900 GO:0048901 biolink:BiologicalProcess anterior lateral line neuromast development The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. go.json http://purl.obolibrary.org/obo/GO_0048901 GO:0000968 biolink:BiologicalProcess tRNA exon ligation An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed. go.json http://purl.obolibrary.org/obo/GO_0000968 GO:0048902 biolink:BiologicalProcess anterior lateral line neuromast deposition The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line. go.json http://purl.obolibrary.org/obo/GO_0048902 GO:0000969 biolink:BiologicalProcess tRNA exon ligation utilizing ATP as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species. go.json http://purl.obolibrary.org/obo/GO_0000969 GO:0048903 biolink:BiologicalProcess anterior lateral line neuromast hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. go.json http://purl.obolibrary.org/obo/GO_0048903 GO:0048904 biolink:BiologicalProcess anterior lateral line neuromast cupula development The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. go.json http://purl.obolibrary.org/obo/GO_0048904 GO:0048905 biolink:BiologicalProcess anterior lateral line neuromast mantle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. go.json http://purl.obolibrary.org/obo/GO_0048905 GO:0048906 biolink:BiologicalProcess anterior lateral line neuromast support cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. go.json http://purl.obolibrary.org/obo/GO_0048906 GO:0000964 biolink:BiologicalProcess mitochondrial RNA 5'-end processing Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. go.json mitochondrial RNA 5' end processing http://purl.obolibrary.org/obo/GO_0000964 GO:0048907 biolink:BiologicalProcess anterior lateral line ganglion development The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear. go.json gALL development http://purl.obolibrary.org/obo/GO_0048907 GO:0000965 biolink:BiologicalProcess mitochondrial RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. go.json mitochondrial RNA 3' end processing http://purl.obolibrary.org/obo/GO_0000965 GO:0048908 biolink:BiologicalProcess anterior lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion. go.json http://purl.obolibrary.org/obo/GO_0048908 GO:0000966 biolink:BiologicalProcess RNA 5'-end processing Any process involved in forming the mature 5' end of an RNA molecule. go.json RNA 5' end processing http://purl.obolibrary.org/obo/GO_0000966 GO:0000967 biolink:BiologicalProcess rRNA 5'-end processing Any process involved in forming the mature 5' end of an rRNA molecule. go.json rRNA 5' end processing http://purl.obolibrary.org/obo/GO_0000967 GO:0048909 biolink:BiologicalProcess anterior lateral line nerve development The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. go.json ALLN development|nALL development|rostral lateral line nerve development http://purl.obolibrary.org/obo/GO_0048909 GO:0000971 biolink:BiologicalProcess tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans. go.json http://purl.obolibrary.org/obo/GO_0000971 GO:0000972 biolink:BiologicalProcess transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript. go.json http://purl.obolibrary.org/obo/GO_0000972 GO:0000973 biolink:BiologicalProcess post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed. go.json posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery http://purl.obolibrary.org/obo/GO_0000973 GO:0000974 biolink:CellularComponent Prp19 complex A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. go.json NTC|Prp19/CDC5 complex|nineteen complex http://purl.obolibrary.org/obo/GO_0000974 GO:0048910 biolink:BiologicalProcess afferent axon development in anterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048910 GO:0048911 biolink:BiologicalProcess efferent axon development in anterior lateral line nerve The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048911 GO:0000970 biolink:BiologicalProcess tRNA exon ligation utilizing GTP as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process. go.json http://purl.obolibrary.org/obo/GO_0000970 GO:0048912 biolink:BiologicalProcess glial cell migration in anterior lateral line nerve The movement of a glial cell along the axons in the anterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048912 GO:0009300 biolink:BiologicalProcess antisense RNA transcription The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. go.json http://purl.obolibrary.org/obo/GO_0009300 GO:0009301 biolink:BiologicalProcess snRNA transcription The synthesis of small nuclear RNA (snRNA) from a DNA template. go.json http://purl.obolibrary.org/obo/GO_0009301 GO:0009302 biolink:BiologicalProcess sno(s)RNA transcription The synthesis of snoRNA class RNA (also referred to as sRNA in Archaea) from a DNA template. go.json sRNA transcription|snoRNA transcription http://purl.obolibrary.org/obo/GO_0009302 GO:0009303 biolink:BiologicalProcess rRNA transcription The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. go.json rRNA biosynthesis|rRNA biosynthetic process|rRNA synthesis http://purl.obolibrary.org/obo/GO_0009303 GO:0009304 biolink:BiologicalProcess tRNA transcription The synthesis of transfer RNA (tRNA) from a DNA template. go.json tRNA biosynthesis|tRNA biosynthetic process|tRNA synthesis http://purl.obolibrary.org/obo/GO_0009304 GO:0000979 biolink:MolecularActivity RNA polymerase II core promoter sequence-specific DNA binding Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. go.json http://purl.obolibrary.org/obo/GO_0000979 GO:0048913 biolink:BiologicalProcess anterior lateral line nerve glial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048913 GO:0009305 biolink:BiologicalProcess obsolete protein biotinylation OBSOLETE. The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid. go.json protein amino acid biotinylation True http://purl.obolibrary.org/obo/GO_0009305 GO:0009306 biolink:BiologicalProcess protein secretion The controlled release of proteins from a cell. go.json glycoprotein secretion|protein secretion during cell fate commitment|protein secretion resulting in cell fate commitment http://purl.obolibrary.org/obo/GO_0009306 GO:0048914 biolink:BiologicalProcess myelination of anterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the anterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048914 GO:0009307 biolink:BiologicalProcess DNA restriction-modification system A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. go.json DNA restriction http://purl.obolibrary.org/obo/GO_0009307 GO:0048915 biolink:BiologicalProcess posterior lateral line system development The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. go.json PLL http://purl.obolibrary.org/obo/GO_0048915 GO:0009308 biolink:BiologicalProcess amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. go.json amine metabolism|cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0009308 goslim_chembl|goslim_pir GO:0048916 biolink:BiologicalProcess posterior lateral line development The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear. go.json PLL development http://purl.obolibrary.org/obo/GO_0048916 GO:0048917 biolink:BiologicalProcess posterior lateral line ganglion development The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear. go.json gPLL development http://purl.obolibrary.org/obo/GO_0048917 GO:0000975 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000975 GO:0009309 biolink:BiologicalProcess amine biosynthetic process The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. go.json amine anabolism|amine biosynthesis|amine formation|amine synthesis http://purl.obolibrary.org/obo/GO_0009309 GO:0048918 biolink:BiologicalProcess posterior lateral line nerve development The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. go.json PLLN development|caudal lateral line nerve development http://purl.obolibrary.org/obo/GO_0048918 GO:0000976 biolink:MolecularActivity transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. go.json bacterial-type RNA polymerase regulatory region DNA binding|bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding|eubacterial-type RNA polymerase regulatory region DNA binding|eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding|regulatory region DNA binding|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0000976 GO:0000977 biolink:MolecularActivity RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. go.json RNA polymerase II regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0000977 GO:0048919 biolink:BiologicalProcess posterior lateral line neuromast development The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. go.json http://purl.obolibrary.org/obo/GO_0048919 GO:0000978 biolink:MolecularActivity RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. go.json RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II promoter proximal region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0000978 GO:0000940 biolink:CellularComponent outer kinetochore The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. go.json condensed chromosome outer kinetochore|condensed nuclear chromosome outer kinetochore|outer kinetochore of condensed chromosome|outer kinetochore of condensed nuclear chromosome|outer kinetochore plate http://purl.obolibrary.org/obo/GO_0000940 GO:0000941 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000941 GO:0048920 biolink:BiologicalProcess posterior lateral line neuromast primordium migration The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. go.json PLL neuromast primordium migration http://purl.obolibrary.org/obo/GO_0048920 GO:0048921 biolink:BiologicalProcess posterior lateral line neuromast cupula development The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. go.json http://purl.obolibrary.org/obo/GO_0048921 GO:0048922 biolink:BiologicalProcess posterior lateral line neuromast deposition The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line. go.json http://purl.obolibrary.org/obo/GO_0048922 GO:0048923 biolink:BiologicalProcess posterior lateral line neuromast hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. go.json http://purl.obolibrary.org/obo/GO_0048923 GO:0048924 biolink:BiologicalProcess posterior lateral line neuromast mantle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. go.json http://purl.obolibrary.org/obo/GO_0048924 GO:0000946 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000946 GO:0000947 biolink:BiologicalProcess amino acid catabolic process to alcohol via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. go.json http://purl.obolibrary.org/obo/GO_0000947 GO:0048925 biolink:BiologicalProcess lateral line system development The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear. go.json http://purl.obolibrary.org/obo/GO_0048925 GO:0000948 biolink:BiologicalProcess amino acid catabolic process to carboxylic acid via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. go.json http://purl.obolibrary.org/obo/GO_0000948 GO:0048926 biolink:BiologicalProcess electrosensory lateral line system development The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048926 GO:0048927 biolink:BiologicalProcess posterior lateral line neuromast support cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. go.json http://purl.obolibrary.org/obo/GO_0048927 GO:0000949 biolink:BiologicalProcess aromatic amino acid family catabolic process to alcohol via Ehrlich pathway The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. go.json http://purl.obolibrary.org/obo/GO_0000949 GO:0000942 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000942 GO:0048928 biolink:BiologicalProcess posterior lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion. go.json http://purl.obolibrary.org/obo/GO_0048928 GO:0048929 biolink:BiologicalProcess efferent axon development in posterior lateral line nerve The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048929 GO:0000943 biolink:CellularComponent retrotransposon nucleocapsid A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog. Wikipedia:Virus-like_particle go.json VLP|Virus-like particle http://purl.obolibrary.org/obo/GO_0000943 GO:0000944 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000944 GO:0000945 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000945 GO:0000950 biolink:BiologicalProcess branched-chain amino acid catabolic process to alcohol via Ehrlich pathway The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. go.json branched chain family amino acid catabolic process to alcohol via Ehrlich pathway http://purl.obolibrary.org/obo/GO_0000950 GO:0000951 biolink:BiologicalProcess methionine catabolic process to 3-methylthiopropanol The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. go.json http://purl.obolibrary.org/obo/GO_0000951 GO:0048930 biolink:BiologicalProcess glial cell migration in posterior lateral line nerve The movement of a glial cell along the axons in the posterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048930 GO:0000952 biolink:BiologicalProcess aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. go.json http://purl.obolibrary.org/obo/GO_0000952 GO:0048931 biolink:BiologicalProcess posterior lateral line nerve glial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048931 GO:0048932 biolink:BiologicalProcess myelination of posterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the posterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048932 GO:0048933 biolink:BiologicalProcess afferent axon development in posterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048933 GO:0048934 biolink:BiologicalProcess peripheral nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. go.json http://purl.obolibrary.org/obo/GO_0048934 GO:0000957 biolink:BiologicalProcess mitochondrial RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0000957 GO:0048935 biolink:BiologicalProcess peripheral nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. go.json http://purl.obolibrary.org/obo/GO_0048935 GO:0000958 biolink:BiologicalProcess mitochondrial mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0000958 GO:0048936 biolink:BiologicalProcess peripheral nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells. go.json http://purl.obolibrary.org/obo/GO_0048936 GO:0048937 biolink:BiologicalProcess lateral line nerve glial cell development The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0048937 GO:0000959 biolink:BiologicalProcess mitochondrial RNA metabolic process The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0000959 GO:0048938 biolink:BiologicalProcess lateral line nerve glial cell morphogenesis involved in differentiation The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048938 GO:0000953 biolink:BiologicalProcess branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. go.json branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway http://purl.obolibrary.org/obo/GO_0000953 GO:0048939 biolink:BiologicalProcess anterior lateral line nerve glial cell development The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0048939 GO:0000954 biolink:BiologicalProcess methionine catabolic process to 3-methylthiopropanoate The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. go.json http://purl.obolibrary.org/obo/GO_0000954 GO:0000955 biolink:BiologicalProcess amino acid catabolic process via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols. go.json http://purl.obolibrary.org/obo/GO_0000955 GO:0000956 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. go.json nuclear mRNA breakdown|nuclear mRNA catabolism|nuclear mRNA degradation http://purl.obolibrary.org/obo/GO_0000956 GO:0048940 biolink:BiologicalProcess anterior lateral line nerve glial cell morphogenesis involved in differentiation The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048940 GO:0048941 biolink:BiologicalProcess posterior lateral line nerve glial cell development The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0048941 GO:0048942 biolink:BiologicalProcess posterior lateral line nerve glial cell morphogenesis involved in differentiation The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048942 GO:0000928 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000928 GO:0000929 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000929 GO:0000924 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000924 GO:0000925 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000925 GO:0000926 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000926 GO:0000927 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000927 GO:0000920 biolink:BiologicalProcess septum digestion after cytokinesis The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. go.json cell separation after cytokinesis|cell separation following cytokinesis|cytokinetic cell separation|daughter cell separation|mitotic cytokinetic cell separation http://purl.obolibrary.org/obo/GO_0000920 GO:0000921 biolink:BiologicalProcess septin ring assembly The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex. go.json septin assembly and septum biosynthesis|septin assembly and septum formation http://purl.obolibrary.org/obo/GO_0000921 GO:0000922 biolink:CellularComponent spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. go.json http://purl.obolibrary.org/obo/GO_0000922 GO:0000923 biolink:CellularComponent equatorial microtubule organizing center A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. go.json EMTOC|equatorial microtubule organising centre http://purl.obolibrary.org/obo/GO_0000923 GO:0000930 biolink:CellularComponent gamma-tubulin complex A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. go.json http://purl.obolibrary.org/obo/GO_0000930 goslim_pir GO:0000939 biolink:CellularComponent inner kinetochore The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin. go.json condensed chromosome inner kinetochore|condensed nuclear chromosome inner kinetochore|inner centromere core complex|inner kinetochore of condensed chromosome|inner kinetochore of condensed nuclear chromosome|inner kinetochore plate http://purl.obolibrary.org/obo/GO_0000939 GO:0000935 biolink:CellularComponent division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments. go.json cell septum surface|complete septum|divison septum|septum surface http://purl.obolibrary.org/obo/GO_0000935 GO:0000936 biolink:CellularComponent primary cell septum A cell septum that forms following nuclear division. go.json primary septum http://purl.obolibrary.org/obo/GO_0000936 GO:0000937 biolink:CellularComponent dolipore septum A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome). go.json http://purl.obolibrary.org/obo/GO_0000937 GO:0000938 biolink:CellularComponent GARP complex A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. go.json Golgi associated retrograde protein complex|VFT tethering complex|Vps fifty three tethering complex http://purl.obolibrary.org/obo/GO_0000938 GO:0000931 biolink:CellularComponent gamma-tubulin ring complex A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. go.json gamma-TuRC|gamma-tubulin large complex|gamma-tubulin large complex, centrosomal|gamma-tubulin large complex, eMTOC|gamma-tubulin large complex, equatorial microtubule organizing center|gamma-tubulin large complex, equatorial microtubule organizing centre|gamma-tubulin large complex, iMTOC|gamma-tubulin large complex, interphase microtubule organizing center|gamma-tubulin large complex, interphase microtubule organizing centre|gamma-tubulin large complex, mitotic spindle pole body|gamma-tubulin large complex, spindle pole body|gamma-tubulin ring complex, centrosomal http://purl.obolibrary.org/obo/GO_0000931 GO:0000932 biolink:CellularComponent P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. Wikipedia:P_body go.json P body|cytoplasmic foci|cytoplasmic mRNA processing body http://purl.obolibrary.org/obo/GO_0000932 GO:0000933 biolink:CellularComponent adventitious septum A cell septum whose formation is independent of nuclear division. go.json http://purl.obolibrary.org/obo/GO_0000933 GO:0000934 biolink:CellularComponent porous cell septum A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments. go.json porous septum http://purl.obolibrary.org/obo/GO_0000934 GO:0000906 biolink:MolecularActivity 6,7-dimethyl-8-ribityllumazine synthase activity Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. EC:2.5.1.78|MetaCyc:LUMAZINESYN-RXN|RHEA:26152 go.json lumazine synthase activity http://purl.obolibrary.org/obo/GO_0000906 GO:0000907 biolink:MolecularActivity sulfonate dioxygenase activity Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2. go.json sulfonate/alpha-ketoglutarate dioxygenase activity|sulphonate dioxygenase activity http://purl.obolibrary.org/obo/GO_0000907 GO:0000908 biolink:MolecularActivity taurine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite. EC:1.14.11.17|KEGG_REACTION:R05320|MetaCyc:RXN0-299|RHEA:15909 go.json 2-aminoethanesulfonate dioxygenase activity|alpha-ketoglutarate-dependent taurine dioxygenase activity|taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming) http://purl.obolibrary.org/obo/GO_0000908 GO:0000909 biolink:BiologicalProcess sporocarp development involved in sexual reproduction The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi. go.json ascus development|fruiting body development involved in sexual reproduction|fruiting body formation involved in sexual reproduction|perfect stage fruiting body development http://purl.obolibrary.org/obo/GO_0000909 GO:0000902 biolink:BiologicalProcess cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized. go.json cellular morphogenesis http://purl.obolibrary.org/obo/GO_0000902 goslim_chembl|goslim_drosophila|goslim_yeast GO:0000903 biolink:BiologicalProcess obsolete regulation of cell shape during vegetative growth phase OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods. go.json cell morphogenesis during vegetative growth phase|cellular morphogenesis during vegetative growth|regulation of cell morphogenesis during vegetative growth phase True http://purl.obolibrary.org/obo/GO_0000903 GO:0000904 biolink:BiologicalProcess obsolete cell morphogenesis involved in differentiation OBSOLETE. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. go.json True http://purl.obolibrary.org/obo/GO_0000904 GO:0000905 biolink:BiologicalProcess sporocarp development involved in asexual reproduction The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction. go.json conidium development|fruiting body formation involved in asexual reproduction|haploid fruiting|homokaryotic fruiting|imperfect stage fruiting body development|monokaryotic fruiting http://purl.obolibrary.org/obo/GO_0000905 GO:0000900 biolink:MolecularActivity mRNA regulatory element binding translation repressor activity Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. go.json translation repressor activity, mRNA regulatory element binding|translation repressor activity, nucleic acid binding http://purl.obolibrary.org/obo/GO_0000900 GO:0000901 biolink:MolecularActivity translation repressor activity, non-nucleic acid binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid. go.json http://purl.obolibrary.org/obo/GO_0000901 GO:1902807 biolink:BiologicalProcess negative regulation of cell cycle G1/S phase transition Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. go.json down regulation of cell cycle G1/S phase transition|down-regulation of cell cycle G1/S phase transition|downregulation of cell cycle G1/S phase transition|inhibition of cell cycle G1/S phase transition http://purl.obolibrary.org/obo/GO_1902807 GO:1902808 biolink:BiologicalProcess positive regulation of cell cycle G1/S phase transition Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. go.json activation of cell cycle G1/S phase transition|up regulation of cell cycle G1/S phase transition|up-regulation of cell cycle G1/S phase transition|upregulation of cell cycle G1/S phase transition http://purl.obolibrary.org/obo/GO_1902808 GO:1902805 biolink:BiologicalProcess positive regulation of synaptic vesicle transport Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport. go.json activation of synaptic vesicle fission|activation of synaptic vesicle fusion|activation of synaptic vesicle transport|positive regulation of synaptic vesicle fission|positive regulation of synaptic vesicle fusion|up regulation of synaptic vesicle fission|up regulation of synaptic vesicle fusion|up regulation of synaptic vesicle transport|up-regulation of synaptic vesicle fission|up-regulation of synaptic vesicle fusion|up-regulation of synaptic vesicle transport|upregulation of synaptic vesicle fission|upregulation of synaptic vesicle fusion|upregulation of synaptic vesicle transport http://purl.obolibrary.org/obo/GO_1902805 GO:1902806 biolink:BiologicalProcess regulation of cell cycle G1/S phase transition Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. go.json http://purl.obolibrary.org/obo/GO_1902806 GO:1902803 biolink:BiologicalProcess regulation of synaptic vesicle transport Any process that modulates the frequency, rate or extent of synaptic vesicle transport. go.json regulation of synaptic vesicle fission|regulation of synaptic vesicle fusion http://purl.obolibrary.org/obo/GO_1902803 GO:1902804 biolink:BiologicalProcess negative regulation of synaptic vesicle transport Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle transport. go.json down regulation of synaptic vesicle fission|down regulation of synaptic vesicle fusion|down regulation of synaptic vesicle transport|down-regulation of synaptic vesicle fission|down-regulation of synaptic vesicle fusion|down-regulation of synaptic vesicle transport|downregulation of synaptic vesicle fission|downregulation of synaptic vesicle fusion|downregulation of synaptic vesicle transport|inhibition of synaptic vesicle fission|inhibition of synaptic vesicle fusion|inhibition of synaptic vesicle transport|negative regulation of synaptic vesicle fission|negative regulation of synaptic vesicle fusion http://purl.obolibrary.org/obo/GO_1902804 GO:1902801 biolink:BiologicalProcess regulation of siRNA-independent facultative heterochromatin formation Any process that modulates the frequency, rate or extent of siRNA-independent facultative heterochromatin assembly. go.json regulation of heterochromatin island assembly|regulation of heterochromatin island formation|regulation of siRNA-independent facultative heterochromatin assembly http://purl.obolibrary.org/obo/GO_1902801 GO:1902802 biolink:BiologicalProcess regulation of siRNA-dependent facultative heterochromatin formation Any process that modulates the frequency, rate or extent of siRNA-dependent facultative heterochromatin formation. go.json regulation of HOOD assembly|regulation of HOOD formation|regulation of heterochromatin domain assembly|regulation of heterochromatin domain formation|regulation of siRNA-dependent facultative heterochromatin assembly http://purl.obolibrary.org/obo/GO_1902802 GO:1902800 biolink:BiologicalProcess positive regulation of phosphodiesterase I activity Any process that activates or increases the frequency, rate or extent of phosphodiesterase I activity. go.json activation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|activation of 5'-NPDase activity|activation of 5'-PDE activity|activation of 5'-PDase activity|activation of 5'-exonuclease activity|activation of 5'-nucleotide phosphodiesterase activity|activation of 5'-phosphodiesterase activity|activation of 5'NPDE activity|activation of PDE I activity|activation of alkaline phosphodiesterase activity|activation of exonuclease I activity|activation of nucleotide pyrophosphatase/phosphodiesterase I activity|activation of oligonucleate 5'-nucleotidohydrolase activity|activation of orthophosphoric diester phosphohydrolase activity|activation of phosphodiesterase I activity|positive regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|positive regulation of 5'-NPDase activity|positive regulation of 5'-PDE activity|positive regulation of 5'-PDase activity|positive regulation of 5'-exonuclease activity|positive regulation of 5'-nucleotide phosphodiesterase activity|positive regulation of 5'-phosphodiesterase activity|positive regulation of 5'NPDE activity|positive regulation of PDE I activity|positive regulation of alkaline phosphodiesterase activity|positive regulation of exonuclease I activity|positive regulation of nucleotide pyrophosphatase/phosphodiesterase I activity|positive regulation of oligonucleate 5'-nucleotidohydrolase activity|positive regulation of orthophosphoric diester phosphohydrolase activity|up regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|up regulation of 5'-NPDase activity|up regulation of 5'-PDE activity|up regulation of 5'-PDase activity|up regulation of 5'-exonuclease activity|up regulation of 5'-nucleotide phosphodiesterase activity|up regulation of 5'-phosphodiesterase activity|up regulation of 5'NPDE activity|up regulation of PDE I activity|up regulation of alkaline phosphodiesterase activity|up regulation of exonuclease I activity|up regulation of nucleotide pyrophosphatase/phosphodiesterase I activity|up regulation of oligonucleate 5'-nucleotidohydrolase activity|up regulation of orthophosphoric diester phosphohydrolase activity|up regulation of phosphodiesterase I activity|up-regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|up-regulation of 5'-NPDase activity|up-regulation of 5'-PDE activity|up-regulation of 5'-PDase activity|up-regulation of 5'-exonuclease activity|up-regulation of 5'-nucleotide phosphodiesterase activity|up-regulation of 5'-phosphodiesterase activity|up-regulation of 5'NPDE activity|up-regulation of PDE I activity|up-regulation of alkaline phosphodiesterase activity|up-regulation of exonuclease I activity|up-regulation of nucleotide pyrophosphatase/phosphodiesterase I activity|up-regulation of oligonucleate 5'-nucleotidohydrolase activity|up-regulation of orthophosphoric diester phosphohydrolase activity|up-regulation of phosphodiesterase I activity|upregulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|upregulation of 5'-NPDase activity|upregulation of 5'-PDE activity|upregulation of 5'-PDase activity|upregulation of 5'-exonuclease activity|upregulation of 5'-nucleotide phosphodiesterase activity|upregulation of 5'-phosphodiesterase activity|upregulation of 5'NPDE activity|upregulation of PDE I activity|upregulation of alkaline phosphodiesterase activity|upregulation of exonuclease I activity|upregulation of nucleotide pyrophosphatase/phosphodiesterase I activity|upregulation of oligonucleate 5'-nucleotidohydrolase activity|upregulation of orthophosphoric diester phosphohydrolase activity|upregulation of phosphodiesterase I activity http://purl.obolibrary.org/obo/GO_1902800 gocheck_do_not_annotate GO:0000917 biolink:BiologicalProcess division septum assembly The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. go.json division septum assembly involved in cell cycle cytokinesis|division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle|division septum formation|division septum formation involved in cell cycle cytokinesis|division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle|division septum formation involved in mitotic cell cycle|formation of division septum|formation of division septum involved in mitotic cell cycle|mitotic division septum assembly|septation|septin assembly and septum biosynthesis|septin assembly and septum biosynthesis involved in mitotic cell cycle|septin assembly and septum formation|septin assembly and septum formation involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_0000917 GO:0000918 biolink:BiologicalProcess division septum site selection The process of marking the site where a division septum will form. go.json selection of site for barrier cell septum biosynthesis|selection of site for barrier cell septum formation|selection of site for division septum formation|septin assembly and septum biosynthesis|septin assembly and septum formation|septum positioning http://purl.obolibrary.org/obo/GO_0000918 GO:0000919 biolink:BiologicalProcess cell plate assembly The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast. go.json cell plate formation http://purl.obolibrary.org/obo/GO_0000919 GO:0000913 biolink:BiologicalProcess preprophase band assembly The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation. go.json preprophase band formation http://purl.obolibrary.org/obo/GO_0000913 GO:0000914 biolink:BiologicalProcess phragmoplast assembly The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles). go.json phragmoplast formation http://purl.obolibrary.org/obo/GO_0000914 GO:0000915 biolink:BiologicalProcess actomyosin contractile ring assembly The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis. go.json constriction ring assembly|contractile ring assembly|cytokinesis, actomyosin contractile ring assembly|cytokinesis, actomyosin contractile ring formation|cytokinesis, actomyosin ring biosynthesis|cytokinesis, actomyosin ring formation|cytokinesis, contractile ring assembly|myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly|myosin filament organization involved in cytokinetic actomyosin contractile ring assembly|myosin filament organization of constriction ring assembly|myosin filament organization of contractile ring assembly http://purl.obolibrary.org/obo/GO_0000915 GO:0000916 biolink:BiologicalProcess actomyosin contractile ring contraction The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle. go.json actomyosin contractile ring constriction|contractile ring contraction involved in cell cycle cytokinesis|cytokinesis, actomyosin ring contraction|cytokinesis, contractile ring contraction http://purl.obolibrary.org/obo/GO_0000916 GO:0000910 biolink:BiologicalProcess cytokinesis The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. Wikipedia:Cytokinesis go.json cell cycle cytokinesis|cytokinesis involved in cell cycle http://purl.obolibrary.org/obo/GO_0000910 gocheck_do_not_manually_annotate|goslim_candida|goslim_generic|goslim_yeast|prokaryote_subset GO:0000911 biolink:BiologicalProcess cytokinesis by cell plate formation The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0000911 GO:1902809 biolink:BiologicalProcess regulation of skeletal muscle fiber differentiation Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. go.json http://purl.obolibrary.org/obo/GO_1902809 GO:0000912 biolink:BiologicalProcess assembly of actomyosin apparatus involved in cytokinesis The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis. go.json actomyosin apparatus assembly involved in cytokinesis|cytokinesis, formation of actomyosin apparatus|formation of actomyosin apparatus involved in cytokinesis http://purl.obolibrary.org/obo/GO_0000912 GO:0034338 biolink:MolecularActivity short-chain carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. go.json butyrate esterase activity|butyryl esterase activity|methylbutyrase activity|methylbutyrate esterase activity|monobutyrase activity|propionyl esterase activity|short-chain esterase activity http://purl.obolibrary.org/obo/GO_0034338 GO:0034339 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor True http://purl.obolibrary.org/obo/GO_0034339 GO:0010369 biolink:CellularComponent chromocenter A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure. go.json http://purl.obolibrary.org/obo/GO_0010369 GO:0009380 biolink:CellularComponent excinuclease repair complex Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. go.json UvrABC excinuclease complex|excinuclease ABC complex http://purl.obolibrary.org/obo/GO_0009380 GO:0009381 biolink:MolecularActivity excinuclease ABC activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind. go.json http://purl.obolibrary.org/obo/GO_0009381 GO:0009382 biolink:CellularComponent imidazoleglycerol-phosphate synthase complex Complex that possesses imidazoleglycerol-phosphate synthase activity. go.json imidazoleglycerol phosphate synthase complex http://purl.obolibrary.org/obo/GO_0009382 GO:0009383 biolink:MolecularActivity rRNA (cytosine-C5-)-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA. Reactome:R-HSA-6790944|Reactome:R-HSA-6793057 go.json rRNA (cytosine-C5-967)-methyltransferase activity|rRNA m5C967 methyltransferase activity http://purl.obolibrary.org/obo/GO_0009383 GO:0009384 biolink:MolecularActivity N-acylmannosamine kinase activity Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. EC:2.7.1.60|MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN|RHEA:23832|Reactome:R-HSA-4085028|Reactome:R-HSA-4088322 go.json ATP:N-acetylmannosamine 6-phosphotransferase activity|ATP:N-acyl-D-mannosamine 6-phosphotransferase activity|N-acetylmannosamine kinase activity|N-acyl-D-mannosamine kinase activity|acetylamidodeoxymannokinase activity|acetylmannosamine kinase activity|acylaminodeoxymannokinase activity|acylmannosamine kinase (phosphorylating)|acylmannosamine kinase activity http://purl.obolibrary.org/obo/GO_0009384 GO:0010363 biolink:BiologicalProcess regulation of plant-type hypersensitive response Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response. go.json regulation of HR|regulation of HR-PCD|regulation of plant hypersensitive response http://purl.obolibrary.org/obo/GO_0010363 GO:0034330 biolink:BiologicalProcess cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. go.json cell junction assembly and maintenance|cell junction biogenesis|cell junction organisation http://purl.obolibrary.org/obo/GO_0034330 goslim_chembl|goslim_generic GO:0009374 biolink:MolecularActivity biotin binding Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. go.json vitamin B7 binding|vitamin H binding http://purl.obolibrary.org/obo/GO_0009374 GO:0034331 biolink:BiologicalProcess cell junction maintenance The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0034331 GO:0010364 biolink:BiologicalProcess regulation of ethylene biosynthetic process Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0010364 GO:0009375 biolink:CellularComponent ferredoxin hydrogenase complex An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances. go.json http://purl.obolibrary.org/obo/GO_0009375 GO:0010361 biolink:BiologicalProcess regulation of anion channel activity by blue light Any process in which blue light modulates the frequency, rate or extent of anion channel activity. go.json regulation by blue light of anion channel activity http://purl.obolibrary.org/obo/GO_0010361 gocheck_do_not_annotate GO:0009376 biolink:CellularComponent HslUV protease complex A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. go.json ClpYQ protease complex http://purl.obolibrary.org/obo/GO_0009376 GO:0034332 biolink:BiologicalProcess adherens junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json adherens junction organisation http://purl.obolibrary.org/obo/GO_0034332 GO:0009377 biolink:MolecularActivity obsolete HslUV protease activity OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins. go.json HslUV protease activity True http://purl.obolibrary.org/obo/GO_0009377 GO:0010362 biolink:BiologicalProcess negative regulation of anion channel activity by blue light Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity. go.json inhibition by blue light of anion channel activity|negative regulation by blue light of anion channel activity http://purl.obolibrary.org/obo/GO_0010362 gocheck_do_not_annotate GO:0034333 biolink:BiologicalProcess adherens junction assembly The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json adherens junction formation http://purl.obolibrary.org/obo/GO_0034333 GO:0034334 biolink:BiologicalProcess adherens junction maintenance The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json http://purl.obolibrary.org/obo/GO_0034334 GO:0009378 biolink:MolecularActivity four-way junction helicase activity Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. go.json ATP-dependent Holliday junction helicase activity|ATP-dependent four-way junction DNA helicase activity|ATP-dependent four-way junction helicase activity|Holliday junction helicase activity http://purl.obolibrary.org/obo/GO_0009378 GO:0010367 biolink:CellularComponent extracellular isoamylase complex A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space. go.json http://purl.obolibrary.org/obo/GO_0010367 GO:0010368 biolink:CellularComponent chloroplast isoamylase complex A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized. go.json http://purl.obolibrary.org/obo/GO_0010368 GO:0009379 biolink:CellularComponent Holliday junction helicase complex A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. go.json http://purl.obolibrary.org/obo/GO_0009379 GO:0034335 biolink:MolecularActivity DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. go.json DNA gyrase activity|DNA-gyrase activity http://purl.obolibrary.org/obo/GO_0034335 GO:0034336 biolink:MolecularActivity misfolded RNA binding Binding to an RNA molecule that has assumed an incorrect conformation. go.json RNA chaperone http://purl.obolibrary.org/obo/GO_0034336 GO:0010365 biolink:BiologicalProcess positive regulation of ethylene biosynthetic process Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0010365 GO:0010366 biolink:BiologicalProcess negative regulation of ethylene biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0010366 GO:0034337 biolink:BiologicalProcess RNA folding The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure. go.json RNA chaperone http://purl.obolibrary.org/obo/GO_0034337 GO:0010360 biolink:BiologicalProcess negative regulation of anion channel activity Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity. go.json http://purl.obolibrary.org/obo/GO_0010360 gocheck_do_not_annotate GO:0034327 biolink:MolecularActivity hexanoyltransferase activity Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0034327 GO:0034328 biolink:MolecularActivity decanoyltransferase activity Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0034328 GO:0034329 biolink:BiologicalProcess cell junction assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. go.json http://purl.obolibrary.org/obo/GO_0034329 GO:0009390 biolink:CellularComponent dimethyl sulfoxide reductase complex An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide. go.json dimethyl sulphoxide reductase complex http://purl.obolibrary.org/obo/GO_0009390 GO:0009391 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009391 GO:0009392 biolink:MolecularActivity N-acetyl-anhydromuramoyl-L-alanine amidase activity Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala. MetaCyc:RXN0-5225 go.json http://purl.obolibrary.org/obo/GO_0009392 GO:0009393 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009393 GO:0009394 biolink:BiologicalProcess 2'-deoxyribonucleotide metabolic process The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json 2'-deoxyribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009394 GO:0009395 biolink:BiologicalProcess phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. go.json phospholipid breakdown|phospholipid catabolism|phospholipid degradation http://purl.obolibrary.org/obo/GO_0009395 GO:0009385 biolink:MolecularActivity N-acylmannosamine-6-phosphate 2-epimerase activity Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate. EC:5.1.3.9|MetaCyc:NANE-RXN|RHEA:25257 go.json N-acylmannosamine-6-P epimerase activity http://purl.obolibrary.org/obo/GO_0009385 GO:0010374 biolink:BiologicalProcess stomatal complex development The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells. go.json http://purl.obolibrary.org/obo/GO_0010374 GO:0009386 biolink:BiologicalProcess translational attenuation Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation. go.json http://purl.obolibrary.org/obo/GO_0009386 GO:0034320 biolink:MolecularActivity alcohol O-hexanoyltransferase activity Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester. go.json http://purl.obolibrary.org/obo/GO_0034320 GO:0010375 biolink:BiologicalProcess stomatal complex patterning The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells. go.json http://purl.obolibrary.org/obo/GO_0010375 GO:0009387 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009387 GO:0010372 biolink:BiologicalProcess positive regulation of gibberellin biosynthetic process Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. go.json positive regulation of gibberellic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0010372 GO:0034321 biolink:MolecularActivity alcohol O-octanoyltransferase activity Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester. go.json http://purl.obolibrary.org/obo/GO_0034321 GO:0009388 biolink:MolecularActivity obsolete antisense RNA OBSOLETE. (Was not defined before being made obsolete). go.json antisense RNA True http://purl.obolibrary.org/obo/GO_0009388 GO:0010373 biolink:BiologicalProcess negative regulation of gibberellin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. go.json negative regulation of gibberellic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0010373 GO:0034322 biolink:MolecularActivity alcohol O-decanoyltransferase activity Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester. go.json http://purl.obolibrary.org/obo/GO_0034322 GO:0034323 biolink:MolecularActivity O-butanoyltransferase activity Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0034323 GO:0010378 biolink:BiologicalProcess temperature compensation of the circadian clock The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms. go.json regulation of the circadian clock by temperature http://purl.obolibrary.org/obo/GO_0010378 GO:0009389 biolink:MolecularActivity dimethyl sulfoxide reductase activity Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O. UM-BBD_reactionID:r0207 go.json dimethyl sulphoxide reductase activity http://purl.obolibrary.org/obo/GO_0009389 GO:0034324 biolink:MolecularActivity O-hexanoyltransferase activity Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0034324 GO:0010379 biolink:BiologicalProcess phaseic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA). MetaCyc:PWY-5271 go.json http://purl.obolibrary.org/obo/GO_0010379 GO:0034325 biolink:MolecularActivity O-decanoyltransferase activity Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0034325 GO:0010376 biolink:BiologicalProcess stomatal complex formation The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells. go.json http://purl.obolibrary.org/obo/GO_0010376 GO:0010377 biolink:BiologicalProcess guard cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere. go.json stomatal cell fate commitment http://purl.obolibrary.org/obo/GO_0010377 GO:0034326 biolink:MolecularActivity butanoyltransferase activity Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0034326 GO:0010370 biolink:CellularComponent perinucleolar chromocenter A chromocenter adjacent to the nucleolus. go.json http://purl.obolibrary.org/obo/GO_0010370 GO:0010371 biolink:BiologicalProcess regulation of gibberellin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. go.json regulation of gibberellic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0010371 GO:0034316 biolink:BiologicalProcess negative regulation of Arp2/3 complex-mediated actin nucleation Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. go.json http://purl.obolibrary.org/obo/GO_0034316 GO:0010349 biolink:MolecularActivity L-galactose dehydrogenase activity Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+. EC:1.1.1.316|MetaCyc:RXN-1884|RHEA:31559 go.json L-galactose 1-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0010349 GO:0034317 biolink:MolecularActivity nicotinic acid riboside kinase activity Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide. MetaCyc:RXN-8443 go.json http://purl.obolibrary.org/obo/GO_0034317 GO:0034318 biolink:MolecularActivity alcohol O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule. go.json AEATase activity|acyl-CoA:alcohol O-acyltransferase activity|acyl-CoA:ethanol O-acyltransferase|acyl-coenzymeA:alcohol O-acyltransferase activity|acyl-coenzymeA:ethanol O-acyltransferase activity|alcohol acyltransferase activity http://purl.obolibrary.org/obo/GO_0034318 GO:0010347 biolink:MolecularActivity L-galactose-1-phosphate phosphatase activity Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate. MetaCyc:RXNQT-4142|RHEA:26349 go.json http://purl.obolibrary.org/obo/GO_0010347 GO:0034319 biolink:MolecularActivity alcohol O-butanoyltransferase activity Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester. go.json http://purl.obolibrary.org/obo/GO_0034319 GO:0010348 biolink:MolecularActivity lithium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in). go.json lithium:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0010348 GO:0009360 biolink:CellularComponent DNA polymerase III complex The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. go.json DNA polymerase III holoenzyme complex http://purl.obolibrary.org/obo/GO_0009360 GO:0009361 biolink:CellularComponent succinate-CoA ligase complex (ADP-forming) A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. go.json succinyl-CoA synthetase, ADP-forming http://purl.obolibrary.org/obo/GO_0009361 GO:0009362 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009362 GO:0009352 biolink:CellularComponent obsolete dihydrolipoyl dehydrogenase complex OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity. go.json dihydrolipoamide dehydrogenase complex|dihydrolipoyl dehydrogenase complex True http://purl.obolibrary.org/obo/GO_0009352 GO:0010341 biolink:MolecularActivity gibberellin carboxyl-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester. go.json http://purl.obolibrary.org/obo/GO_0010341 GO:0010342 biolink:BiologicalProcess endosperm cellularization The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization. go.json cellularization of endosperm http://purl.obolibrary.org/obo/GO_0010342 GO:0009353 biolink:CellularComponent mitochondrial oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus. go.json http://purl.obolibrary.org/obo/GO_0009353 GO:0034310 biolink:BiologicalProcess primary alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. go.json monohydric alcohol catabolic process|primary alcohol breakdown|primary alcohol catabolism|primary alcohol degradation http://purl.obolibrary.org/obo/GO_0034310 GO:0009354 biolink:CellularComponent obsolete dihydrolipoamide S-succinyltransferase complex OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex. go.json dihydrolipoamide S-succinyltransferase complex True http://purl.obolibrary.org/obo/GO_0009354 GO:0034311 biolink:BiologicalProcess diol metabolic process The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. go.json dihydric alcohol metabolic process|diol metabolism http://purl.obolibrary.org/obo/GO_0034311 GO:0009355 biolink:CellularComponent DNA polymerase V complex A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis. go.json http://purl.obolibrary.org/obo/GO_0009355 GO:0010340 biolink:MolecularActivity carboxyl-O-methyltransferase activity Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. go.json http://purl.obolibrary.org/obo/GO_0010340 GO:0034312 biolink:BiologicalProcess diol biosynthetic process The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms. go.json dihydric alcohol biosynthetic process|diol anabolism|diol biosynthesis|diol formation|diol synthesis http://purl.obolibrary.org/obo/GO_0034312 GO:0010345 biolink:BiologicalProcess suberin biosynthetic process The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols. MetaCyc:PWY-1121 go.json http://purl.obolibrary.org/obo/GO_0010345 GO:0009356 biolink:CellularComponent aminodeoxychorismate synthase complex A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity. go.json 4-amino-4-deoxychorismate synthase complex|ADC synthase complex|p-aminobenzoate synthetase complex http://purl.obolibrary.org/obo/GO_0009356 GO:0034313 biolink:BiologicalProcess diol catabolic process The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms. go.json dihydric alcohol catabolic process|diol breakdown|diol catabolism|diol degradation http://purl.obolibrary.org/obo/GO_0034313 GO:0010346 biolink:BiologicalProcess shoot axis formation The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts. go.json shoot formation http://purl.obolibrary.org/obo/GO_0010346 GO:0009357 biolink:CellularComponent protein-N(PI)-phosphohistidine-sugar phosphotransferase complex An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system. go.json http://purl.obolibrary.org/obo/GO_0009357 GO:0009358 biolink:CellularComponent polyphosphate kinase complex A protein complex that possesses polyphosphate kinase activity. go.json http://purl.obolibrary.org/obo/GO_0009358 GO:0034314 biolink:BiologicalProcess Arp2/3 complex-mediated actin nucleation The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. go.json actin filament branch nucleation|branched actin filament nucleation http://purl.obolibrary.org/obo/GO_0034314 GO:0010343 biolink:BiologicalProcess singlet oxygen-mediated programmed cell death Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes. go.json light-dependent programmed cell death|programmed cell death in response to singlet oxygen http://purl.obolibrary.org/obo/GO_0010343 GO:0010344 biolink:BiologicalProcess seed oilbody biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination. go.json oleosome biogenesis|seed oil body organization|spherosome biogenesis http://purl.obolibrary.org/obo/GO_0010344 GO:0009359 biolink:CellularComponent type II site-specific deoxyribonuclease complex A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. go.json type II restriction enzyme complex http://purl.obolibrary.org/obo/GO_0009359 GO:0034315 biolink:BiologicalProcess regulation of Arp2/3 complex-mediated actin nucleation Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. go.json http://purl.obolibrary.org/obo/GO_0034315 GO:0034305 biolink:BiologicalProcess regulation of asexual sporulation Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis. go.json regulation of asexual spore formation|regulation of mitotic spore formation|regulation of mitotic sporulation http://purl.obolibrary.org/obo/GO_0034305 GO:0034306 biolink:BiologicalProcess regulation of sexual sporulation Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae. go.json MAPKKK cascade during sporulation|regulation of meiotic spore formation|regulation of meiotic sporulation|regulation of sexual spore formation http://purl.obolibrary.org/obo/GO_0034306 GO:0010358 biolink:BiologicalProcess leaf shaping The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed. go.json leaf structural organization http://purl.obolibrary.org/obo/GO_0010358 GO:0034307 biolink:BiologicalProcess regulation of ascospore formation Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae. go.json MAPKKK cascade during sporulation http://purl.obolibrary.org/obo/GO_0034307 GO:0010359 biolink:BiologicalProcess regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity. go.json http://purl.obolibrary.org/obo/GO_0010359 gocheck_do_not_annotate GO:0034308 biolink:BiologicalProcess primary alcohol metabolic process The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. go.json monohydric alcohol metabolic process|primary alcohol metabolism http://purl.obolibrary.org/obo/GO_0034308 GO:0034309 biolink:BiologicalProcess primary alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. go.json monohydric alcohol biosynthetic process|primary alcohol anabolism|primary alcohol biosynthesis|primary alcohol formation|primary alcohol synthesis http://purl.obolibrary.org/obo/GO_0034309 GO:0009370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009370 GO:0009371 biolink:BiologicalProcess obsolete positive regulation of transcription by pheromones OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription. go.json activation of transcription by pheromones|stimulation of transcription by pheromones|up regulation of transcription by pheromones|up-regulation of transcription by pheromones|upregulation of transcription by pheromones True http://purl.obolibrary.org/obo/GO_0009371 GO:0009372 biolink:BiologicalProcess quorum sensing The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. Wikipedia:Quorum_sensing go.json cell-cell signaling involved in quorum sensing|detection of cell density by secreted molecule|quorum sensing system http://purl.obolibrary.org/obo/GO_0009372 goslim_metagenomics|goslim_pir GO:0009373 biolink:BiologicalProcess obsolete regulation of transcription by pheromones OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent of transcription. go.json True http://purl.obolibrary.org/obo/GO_0009373 GO:0010352 biolink:BiologicalProcess lithium ion export across the plasma membrane The directed movement of lithium ion out of a cell or organelle. go.json lithium export|lithium ion efflux|lithium ion export http://purl.obolibrary.org/obo/GO_0010352 GO:0010353 biolink:BiologicalProcess response to trehalose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus. go.json response to trehalose stimulus http://purl.obolibrary.org/obo/GO_0010353 GO:0009364 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009364 GO:0010350 biolink:BiologicalProcess cellular response to magnesium starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium. go.json http://purl.obolibrary.org/obo/GO_0010350 GO:0009365 biolink:CellularComponent protein histidine kinase complex A complex that possesses protein histidine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0009365 GO:0034300 biolink:BiologicalProcess sporangiospore formation The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0034300 GO:0010351 biolink:BiologicalProcess lithium ion transport The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json lithium transport http://purl.obolibrary.org/obo/GO_0010351 GO:0009366 biolink:CellularComponent enterobactin synthetase complex A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. MetaCyc:ENTMULTI-CPLX go.json enterochelin synthetase complex http://purl.obolibrary.org/obo/GO_0009366 GO:0010356 biolink:MolecularActivity homogentisate geranylgeranyltransferase activity Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol. go.json http://purl.obolibrary.org/obo/GO_0010356 GO:0034301 biolink:BiologicalProcess endospore formation The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions. go.json http://purl.obolibrary.org/obo/GO_0034301 GO:0009367 biolink:CellularComponent obsolete prepilin peptidase complex OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group. go.json prepilin peptidase complex True http://purl.obolibrary.org/obo/GO_0009367 GO:0010357 biolink:MolecularActivity homogentisate solanesyltransferase activity Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate. go.json http://purl.obolibrary.org/obo/GO_0010357 GO:0034302 biolink:BiologicalProcess akinete formation The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria. go.json http://purl.obolibrary.org/obo/GO_0034302 GO:0009368 biolink:CellularComponent endopeptidase Clp complex A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form. go.json http://purl.obolibrary.org/obo/GO_0009368 goslim_pir GO:0009369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009369 GO:0034303 biolink:BiologicalProcess myxospore formation The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria. go.json http://purl.obolibrary.org/obo/GO_0034303 GO:0010354 biolink:MolecularActivity homogentisate prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid. go.json http://purl.obolibrary.org/obo/GO_0010354 GO:0034304 biolink:BiologicalProcess actinomycete-type spore formation The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales. go.json http://purl.obolibrary.org/obo/GO_0034304 GO:0010355 biolink:MolecularActivity homogentisate farnesyltransferase activity Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol. go.json http://purl.obolibrary.org/obo/GO_0010355 GO:0010327 biolink:MolecularActivity acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate. go.json hexenol acetyltransferase http://purl.obolibrary.org/obo/GO_0010327 GO:0010328 biolink:MolecularActivity auxin influx transmembrane transporter activity Enables the transfer of auxin, from one side of a membrane to the other, into a cell. go.json auxin influx facilitator http://purl.obolibrary.org/obo/GO_0010328 GO:0010325 biolink:BiologicalProcess raffinose family oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization). go.json raffinose family oligosaccharide biosynthesis http://purl.obolibrary.org/obo/GO_0010325 GO:0010326 biolink:MolecularActivity methionine-oxo-acid transaminase activity Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid. MetaCyc:R15-RXN go.json http://purl.obolibrary.org/obo/GO_0010326 GO:0010329 biolink:MolecularActivity auxin efflux transmembrane transporter activity Enables the transfer of auxin, from one side of a membrane to the other, out of a cell. go.json auxin efflux carrier|auxin efflux facilitator http://purl.obolibrary.org/obo/GO_0010329 GO:0009340 biolink:CellularComponent DNA topoisomerase IV complex A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA. go.json http://purl.obolibrary.org/obo/GO_0009340 GO:0009330 biolink:CellularComponent DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity. go.json http://purl.obolibrary.org/obo/GO_0009330 GO:0009331 biolink:CellularComponent glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. go.json http://purl.obolibrary.org/obo/GO_0009331 GO:0010320 biolink:MolecularActivity obsolete arginine/lysine endopeptidase activity OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles. go.json arginine/lysine endopeptidase activity True http://purl.obolibrary.org/obo/GO_0010320 GO:0009332 biolink:CellularComponent glutamate-tRNA ligase complex An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu). go.json http://purl.obolibrary.org/obo/GO_0009332 GO:0009333 biolink:CellularComponent cysteine synthase complex Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A. MetaCyc:CYSSYNMULTI-CPLX go.json http://purl.obolibrary.org/obo/GO_0009333 GO:0009334 biolink:CellularComponent 3-phenylpropionate dioxygenase complex Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol). MetaCyc:HCAMULTI-CPLX go.json http://purl.obolibrary.org/obo/GO_0009334 GO:0010323 biolink:BiologicalProcess negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). go.json down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway http://purl.obolibrary.org/obo/GO_0010323 GO:0010324 biolink:BiologicalProcess membrane invagination The infolding of a membrane. go.json single-organism membrane invagination http://purl.obolibrary.org/obo/GO_0010324 goslim_yeast GO:0009335 biolink:CellularComponent obsolete holo-[acyl-carrier protein] synthase complex OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]. go.json holo-ACP synthase complex|holo-[acyl-carrier protein] synthase complex True http://purl.obolibrary.org/obo/GO_0009335 GO:0010321 biolink:BiologicalProcess regulation of vegetative phase change Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. go.json http://purl.obolibrary.org/obo/GO_0010321 GO:0009336 biolink:CellularComponent sulfate adenylyltransferase complex (ATP) An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP. go.json sulphate adenylyltransferase complex (ATP) http://purl.obolibrary.org/obo/GO_0009336 GO:0010322 biolink:BiologicalProcess regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). go.json regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway http://purl.obolibrary.org/obo/GO_0010322 GO:0009337 biolink:CellularComponent sulfite reductase complex (NADPH) A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide. go.json sulphite reductase complex (NADPH) http://purl.obolibrary.org/obo/GO_0009337 GO:0009338 biolink:CellularComponent exodeoxyribonuclease V complex An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. go.json http://purl.obolibrary.org/obo/GO_0009338 GO:0009339 biolink:CellularComponent glycolate oxidase complex An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN). go.json http://purl.obolibrary.org/obo/GO_0009339 GO:0010338 biolink:BiologicalProcess leaf formation The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0010338 GO:0010339 biolink:CellularComponent external side of cell wall The side of the cell wall that is opposite to the side that faces the cell and its contents. go.json http://purl.obolibrary.org/obo/GO_0010339 GO:0010336 biolink:BiologicalProcess gibberellic acid homeostasis Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation. go.json gibberellin homeostasis http://purl.obolibrary.org/obo/GO_0010336 GO:0010337 biolink:BiologicalProcess regulation of salicylic acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid. go.json regulation of salicylic acid metabolism http://purl.obolibrary.org/obo/GO_0010337 GO:0009350 biolink:CellularComponent ethanolamine ammonia-lyase complex An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. go.json http://purl.obolibrary.org/obo/GO_0009350 GO:0009351 biolink:CellularComponent obsolete dihydrolipoamide S-acyltransferase complex OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide. go.json dihydrolipoamide S-acyltransferase complex True http://purl.obolibrary.org/obo/GO_0009351 GO:0010330 biolink:CellularComponent cellulose synthase complex A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall. go.json CESA complex http://purl.obolibrary.org/obo/GO_0010330 GO:0009341 biolink:CellularComponent beta-galactosidase complex A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. go.json http://purl.obolibrary.org/obo/GO_0009341 goslim_metagenomics GO:0010331 biolink:MolecularActivity gibberellin binding Binding to a gibberellin, a plant hormone that regulates aspects of plant growth. go.json gibberellic acid receptor|gibberellin receptor http://purl.obolibrary.org/obo/GO_0010331 GO:0009342 biolink:CellularComponent glutamate synthase complex (NADPH) A complex that possesses glutamate synthase (NADPH) activity. go.json http://purl.obolibrary.org/obo/GO_0009342 GO:0009343 biolink:CellularComponent obsolete biotin carboxylase complex OBSOLETE. An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2). go.json True http://purl.obolibrary.org/obo/GO_0009343 GO:0009344 biolink:CellularComponent nitrite reductase complex [NAD(P)H] Complex that possesses nitrite reductase [NAD(P)H] activity. go.json http://purl.obolibrary.org/obo/GO_0009344 GO:0009345 biolink:CellularComponent glycine-tRNA ligase complex A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly). go.json glycine-tRNA synthetase complex http://purl.obolibrary.org/obo/GO_0009345 GO:0010334 biolink:MolecularActivity sesquiterpene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons. go.json http://purl.obolibrary.org/obo/GO_0010334 GO:0009346 biolink:CellularComponent ATP-independent citrate lyase complex Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria. MetaCyc:ACECITLY-CPLX go.json citrate lyase complex|citrate synthase complex http://purl.obolibrary.org/obo/GO_0009346 goslim_metagenomics GO:0010335 biolink:BiologicalProcess response to non-ionic osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment. go.json http://purl.obolibrary.org/obo/GO_0010335 GO:0010332 biolink:BiologicalProcess response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. go.json response to gamma ray|response to gamma-ray photon http://purl.obolibrary.org/obo/GO_0010332 GO:0009347 biolink:CellularComponent aspartate carbamoyltransferase complex A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides. go.json http://purl.obolibrary.org/obo/GO_0009347 GO:0009348 biolink:CellularComponent obsolete ornithine carbamoyltransferase complex OBSOLETE. A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. go.json True http://purl.obolibrary.org/obo/GO_0009348 GO:0010333 biolink:MolecularActivity terpene synthase activity Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units. go.json http://purl.obolibrary.org/obo/GO_0010333 GO:0009349 biolink:CellularComponent riboflavin synthase complex An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. go.json http://purl.obolibrary.org/obo/GO_0009349 goslim_metagenomics GO:0000982 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000982 GO:0000983 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000983 GO:0000984 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000984 GO:0000985 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000985 GO:0000980 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000980 GO:0000981 biolink:MolecularActivity DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. go.json RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding|RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding|RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding|RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|transcription factor|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity http://purl.obolibrary.org/obo/GO_0000981 GO:0010305 biolink:BiologicalProcess leaf vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the leaf of vascular plants. go.json http://purl.obolibrary.org/obo/GO_0010305 GO:0010306 biolink:BiologicalProcess rhamnogalacturonan II biosynthetic process The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms. go.json http://purl.obolibrary.org/obo/GO_0010306 GO:0010303 biolink:MolecularActivity limit dextrinase activity Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan. EC:3.2.1.142|MetaCyc:3.2.1.10-RXN|MetaCyc:3.2.1.142-RXN|MetaCyc:RXN-1824 go.json R-enzyme|amylopectin-1,6-glucosidase activity|dextrin alpha-1,6-glucanohydrolase activity http://purl.obolibrary.org/obo/GO_0010303 GO:0010304 biolink:BiologicalProcess PSII associated light-harvesting complex II catabolic process The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II. go.json LHCII catabolism http://purl.obolibrary.org/obo/GO_0010304 GO:0010309 biolink:MolecularActivity acireductone dioxygenase [iron(II)-requiring] activity Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+. EC:1.13.11.54|KEGG_REACTION:R07364|MetaCyc:R147-RXN|RHEA:24504|Reactome:R-HSA-1237119 go.json 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity|1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)|2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase|ARD'|ARD1|E-2'|aci-reductone dioxygenase|acireductone dioxygenase (Fe2+-requiring) activity|acireductone dioxygenase activity http://purl.obolibrary.org/obo/GO_0010309 GO:0010307 biolink:MolecularActivity acetylglutamate kinase regulator activity Binds to and modulates the activity of acetylglutamate kinase. go.json http://purl.obolibrary.org/obo/GO_0010307 GO:0010308 biolink:MolecularActivity acireductone dioxygenase (Ni2+-requiring) activity Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate. EC:1.13.11.53|KEGG_REACTION:R07363|MetaCyc:R146-RXN|RHEA:14161 go.json 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)|2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity|ARD activity|E-2 activity|acireductone dioxygenase activity http://purl.obolibrary.org/obo/GO_0010308 GO:0009310 biolink:BiologicalProcess amine catabolic process The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. go.json amine breakdown|amine catabolism|amine degradation http://purl.obolibrary.org/obo/GO_0009310 GO:0009311 biolink:BiologicalProcess oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. go.json multicellular organismal oligosaccharide metabolic process|oligosaccharide metabolism http://purl.obolibrary.org/obo/GO_0009311 goslim_yeast GO:0010301 biolink:MolecularActivity xanthoxin dehydrogenase activity Catalysis of the reaction: NAD+ + xanthoxin = (+)-abscisic aldehyde + H+ + NADH. EC:1.1.1.288|KEGG_REACTION:R06954|MetaCyc:1.1.1.288-RXN|RHEA:12548 go.json ABA2|xanthoxin oxidase activity|xanthoxin:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0010301 GO:0009312 biolink:BiologicalProcess oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. go.json oligosaccharide anabolism|oligosaccharide biosynthesis|oligosaccharide formation|oligosaccharide synthesis http://purl.obolibrary.org/obo/GO_0009312 GO:0009313 biolink:BiologicalProcess oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. go.json multicellular organismal oligosaccharide catabolic process|oligosaccharide breakdown|oligosaccharide catabolism|oligosaccharide degradation http://purl.obolibrary.org/obo/GO_0009313 GO:0010302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010302 GO:0009314 biolink:BiologicalProcess response to radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. go.json response to electromagnetic radiation stimulus|response to radiation stimulus http://purl.obolibrary.org/obo/GO_0009314 GO:0010300 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010300 GO:0009315 biolink:BiologicalProcess obsolete drug resistance OBSOLETE. (Was not defined before being made obsolete). go.json drug resistance True http://purl.obolibrary.org/obo/GO_0009315 GO:0009316 biolink:CellularComponent 3-isopropylmalate dehydratase complex A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. MetaCyc:3-ISOPROPYLMALISOM-CPLX go.json isopropylmalate isomerase complex http://purl.obolibrary.org/obo/GO_0009316 GO:0009317 biolink:CellularComponent acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. go.json ACCase complex http://purl.obolibrary.org/obo/GO_0009317 goslim_metagenomics|goslim_pir GO:0009318 biolink:CellularComponent exodeoxyribonuclease VII complex An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0009318 GO:0009319 biolink:CellularComponent cytochrome o ubiquinol oxidase complex A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups. MetaCyc:CYT-O-UBIOX-CPLX go.json http://purl.obolibrary.org/obo/GO_0009319 GO:0000986 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000986 GO:0000987 biolink:MolecularActivity cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. go.json bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding|bacterial-type RNA polymerase enhancer sequence-specific DNA binding|bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding|bacterial-type cis-regulatory region sequence-specific DNA binding|bacterial-type proximal promoter sequence-specific DNA binding|cis-regulatory region binding|core promoter proximal region DNA binding|core promoter proximal region sequence-specific DNA binding|enhancer binding|enhancer sequence-specific DNA binding|eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding|promoter proximal region sequence-specific DNA binding|proximal promoter sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0000987 GO:0000988 biolink:MolecularActivity obsolete transcription factor activity, protein binding OBSOLETE. Binding to a protein or protein complex, to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json protein binding transcription factor activity|transcription factor activity True http://purl.obolibrary.org/obo/GO_0000988 GO:0000989 biolink:MolecularActivity obsolete transcription factor activity, transcription factor binding OBSOLETE. Binding to a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json transcription factor binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0000989 GO:0000993 biolink:MolecularActivity RNA polymerase II complex binding Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. go.json RNA polymerase II core binding|RNAP II core binding http://purl.obolibrary.org/obo/GO_0000993 GO:0000994 biolink:MolecularActivity RNA polymerase III core binding Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. go.json http://purl.obolibrary.org/obo/GO_0000994 GO:0000995 biolink:MolecularActivity RNA polymerase III general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. go.json RNA polymerase III general initiation factor activity|RNA polymerase III transcription factor activity, sequence-specific DNA binding|core RNA polymerase III binding transcription factor activity|sequence-specific DNA binding RNA polymerase III transcription factor activity|transcription factor activity, core RNA polymerase III binding http://purl.obolibrary.org/obo/GO_0000995 GO:0000996 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000996 GO:0000990 biolink:MolecularActivity obsolete transcription factor activity, core RNA polymerase binding OBSOLETE. Binding to an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json core RNA polymerase binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0000990 GO:0000991 biolink:MolecularActivity obsolete transcription factor activity, core RNA polymerase II binding OBSOLETE. Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. go.json core RNA polymerase II binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0000991 GO:0000992 biolink:MolecularActivity RNA polymerase III cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes. go.json http://purl.obolibrary.org/obo/GO_0000992 GO:0010316 biolink:CellularComponent pyrophosphate-dependent phosphofructokinase complex Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate. go.json PFK complex http://purl.obolibrary.org/obo/GO_0010316 goslim_pir GO:0010317 biolink:CellularComponent pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. go.json PFK complex, alpha-subunit http://purl.obolibrary.org/obo/GO_0010317 GO:0010314 biolink:MolecularActivity phosphatidylinositol-5-phosphate binding Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. go.json http://purl.obolibrary.org/obo/GO_0010314 GO:0010315 biolink:BiologicalProcess auxin export across the plasma membrane The directed movement of auxins from inside of a cell, across the plasma membrane and into the extracellular region. go.json auxin efflux|auxin export http://purl.obolibrary.org/obo/GO_0010315 GO:0010318 biolink:CellularComponent pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. go.json PFK complex, beta-subunit http://purl.obolibrary.org/obo/GO_0010318 GO:0010319 biolink:CellularComponent stromule Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types. Wikipedia:Stromule go.json Stroma-filled tubule http://purl.obolibrary.org/obo/GO_0010319 GO:0009320 biolink:CellularComponent phosphoribosylaminoimidazole carboxylase complex A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity. go.json http://purl.obolibrary.org/obo/GO_0009320 GO:0009321 biolink:CellularComponent alkyl hydroperoxide reductase complex An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides. go.json http://purl.obolibrary.org/obo/GO_0009321 GO:0009322 biolink:CellularComponent trimethylamine-N-oxide reductase complex An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine. go.json http://purl.obolibrary.org/obo/GO_0009322 GO:0009323 biolink:CellularComponent obsolete ribosomal-protein-alanine N-acetyltransferase complex OBSOLETE. An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine. go.json True http://purl.obolibrary.org/obo/GO_0009323 GO:0010312 biolink:BiologicalProcess detoxification of zinc ion Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion. go.json http://purl.obolibrary.org/obo/GO_0010312 GO:0010313 biolink:MolecularActivity phytochrome binding Binding to a phytochrome. go.json http://purl.obolibrary.org/obo/GO_0010313 GO:0009324 biolink:CellularComponent D-amino-acid dehydrogenase complex A protein complex that possesses D-amino-acid dehydrogenase activity. go.json http://purl.obolibrary.org/obo/GO_0009324 GO:0009325 biolink:CellularComponent nitrate reductase complex An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. go.json http://purl.obolibrary.org/obo/GO_0009325 GO:0010310 biolink:BiologicalProcess regulation of hydrogen peroxide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. go.json regulation of hydrogen peroxide metabolism http://purl.obolibrary.org/obo/GO_0010310 GO:0009326 biolink:CellularComponent formate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2). go.json http://purl.obolibrary.org/obo/GO_0009326 GO:0010311 biolink:BiologicalProcess lateral root formation The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper. go.json lateral root primordium development http://purl.obolibrary.org/obo/GO_0010311 GO:0009327 biolink:CellularComponent obsolete NAD(P)+ transhydrogenase complex (AB-specific) OBSOLETE. A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified. go.json True http://purl.obolibrary.org/obo/GO_0009327 GO:0009328 biolink:CellularComponent phenylalanine-tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). go.json http://purl.obolibrary.org/obo/GO_0009328 GO:0009329 biolink:CellularComponent acetate CoA-transferase complex A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA. go.json http://purl.obolibrary.org/obo/GO_0009329 GO:0000997 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000997 GO:0000998 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000998 GO:0000999 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000999 GO:1902779 biolink:BiologicalProcess cellular response to alkane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902779 GO:1902777 biolink:BiologicalProcess 6-sulfoquinovose(1-) catabolic process The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-). go.json 6-sulfoquinovose(1-) breakdown|6-sulfoquinovose(1-) catabolism|6-sulfoquinovose(1-) degradation http://purl.obolibrary.org/obo/GO_1902777 GO:1902778 biolink:BiologicalProcess response to alkane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus. go.json process resulting in tolerance to alkane http://purl.obolibrary.org/obo/GO_1902778 GO:1902775 biolink:BiologicalProcess mitochondrial large ribosomal subunit assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit. go.json 39S ribosomal subunit, mitochondrial assembly|39S ribosomal subunit, mitochondrial formation|mitochondrial large ribosomal subunit formation http://purl.obolibrary.org/obo/GO_1902775 GO:1902776 biolink:BiologicalProcess 6-sulfoquinovose(1-) metabolic process The chemical reactions and pathways involving 6-sulfoquinovose(1-). go.json 6-sulfoquinovose(1-) metabolism http://purl.obolibrary.org/obo/GO_1902776 GO:1902773 biolink:CellularComponent GTPase activator complex A protein complex which is capable of GTPase activator activity. go.json http://purl.obolibrary.org/obo/GO_1902773 GO:1902774 biolink:BiologicalProcess late endosome to lysosome transport The directed movement of substances from late endosome to lysosome. go.json prevacuolar compartment to lysosome transport http://purl.obolibrary.org/obo/GO_1902774 GO:1902771 biolink:BiologicalProcess positive regulation of choline O-acetyltransferase activity Any process that activates or increases the frequency, rate or extent of choline O-acetyltransferase activity. go.json activation of CHOACTase activity|activation of acetyl-CoA:choline O-acetyltransferase activity|activation of choline O-acetyltransferase activity|activation of choline acetylase activity|activation of choline acetyltransferase activity|positive regulation of CHOACTase activity|positive regulation of acetyl-CoA:choline O-acetyltransferase activity|positive regulation of choline acetylase activity|positive regulation of choline acetyltransferase activity|up regulation of CHOACTase activity|up regulation of acetyl-CoA:choline O-acetyltransferase activity|up regulation of choline O-acetyltransferase activity|up regulation of choline acetylase activity|up regulation of choline acetyltransferase activity|up-regulation of CHOACTase activity|up-regulation of acetyl-CoA:choline O-acetyltransferase activity|up-regulation of choline O-acetyltransferase activity|up-regulation of choline acetylase activity|up-regulation of choline acetyltransferase activity|upregulation of CHOACTase activity|upregulation of acetyl-CoA:choline O-acetyltransferase activity|upregulation of choline O-acetyltransferase activity|upregulation of choline acetylase activity|upregulation of choline acetyltransferase activity http://purl.obolibrary.org/obo/GO_1902771 gocheck_do_not_annotate GO:1902772 biolink:BiologicalProcess positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway Any positive regulation of phosphorelay signal transduction system that is involved in hydrogen peroxide mediated signaling pathway. go.json activation of two-component signal transduction involved in H2O2 mediated signaling pathway|activation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway|activation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway|positive regulation of histidyl-aspartyl phosphorelay involved in H2O2 mediated signaling pathway|positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signaling pathway|positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signalling pathway|positive regulation of phosphorelay signal transduction system involved in H2O2 mediated signaling pathway|positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signalling pathway|positive regulation of two-component signal transduction system (phosphorelay) involved in H2O2 mediated signaling pathway|positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signaling pathway|positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signalling pathway|stimulation of two-component signal transduction involved in H2O2 mediated signaling pathway|stimulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway|stimulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway|up regulation of two-component signal transduction involved in H2O2 mediated signaling pathway|up regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway|up regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway|up-regulation of two-component signal transduction involved in H2O2 mediated signaling pathway|up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway|up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway|upregulation of two-component signal transduction involved in H2O2 mediated signaling pathway|upregulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway|upregulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway http://purl.obolibrary.org/obo/GO_1902772 GO:1902780 biolink:BiologicalProcess response to nonane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902780 GO:0034297 biolink:BiologicalProcess oidium formation The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus. go.json http://purl.obolibrary.org/obo/GO_0034297 GO:1902781 biolink:BiologicalProcess cellular response to nonane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902781 GO:0034298 biolink:BiologicalProcess arthrospore formation The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation. go.json arthroconidium formation http://purl.obolibrary.org/obo/GO_0034298 GO:0034299 biolink:BiologicalProcess reproductive blastospore formation The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota. go.json blastoconidium formation http://purl.obolibrary.org/obo/GO_0034299 GO:0034290 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034290 GO:0034291 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034291 GO:0034292 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034292 GO:0034293 biolink:BiologicalProcess sexual sporulation The formation of spores derived from the products of meiosis. go.json meiotic spore formation|meiotic sporulation|sexual spore formation http://purl.obolibrary.org/obo/GO_0034293 GO:0034294 biolink:BiologicalProcess sexual spore wall assembly The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis. go.json sexual spore wall formation http://purl.obolibrary.org/obo/GO_0034294 GO:0034295 biolink:BiologicalProcess basidiospore formation The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium. go.json http://purl.obolibrary.org/obo/GO_0034295 GO:0034296 biolink:BiologicalProcess zygospore formation The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away. go.json http://purl.obolibrary.org/obo/GO_0034296 GO:1902788 biolink:BiologicalProcess response to isooctane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902788 GO:1902789 biolink:BiologicalProcess cellular response to isooctane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902789 GO:1902786 biolink:BiologicalProcess response to dodecane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902786 GO:1902787 biolink:BiologicalProcess cellular response to dodecane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902787 GO:1902784 biolink:BiologicalProcess response to undecane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902784 GO:1902785 biolink:BiologicalProcess cellular response to undecane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902785 GO:1902782 biolink:BiologicalProcess response to decane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902782 GO:1902783 biolink:BiologicalProcess cellular response to decane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus. go.json http://purl.obolibrary.org/obo/GO_1902783 GO:0034286 biolink:BiologicalProcess response to maltose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus. go.json response to maltose stimulus http://purl.obolibrary.org/obo/GO_0034286 GO:1902791 biolink:BiologicalProcess undecan-2-one biosynthetic process The chemical reactions and pathways resulting in the formation of undecan-2-one. go.json undecan-2-one anabolism|undecan-2-one biosynthesis|undecan-2-one formation|undecan-2-one synthesis http://purl.obolibrary.org/obo/GO_1902791 GO:0034287 biolink:BiologicalProcess detection of monosaccharide stimulus The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal. go.json perception of monosaccharide stimulus http://purl.obolibrary.org/obo/GO_0034287 GO:1902792 biolink:CellularComponent pyrroline-5-carboxylate reductase complex A protein complex which is capable of pyrroline-5-carboxylate reductase activity. go.json http://purl.obolibrary.org/obo/GO_1902792 GO:0034288 biolink:BiologicalProcess detection of disaccharide stimulus The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal. go.json perception of disaccharide stimulus http://purl.obolibrary.org/obo/GO_0034288 GO:1902790 biolink:BiologicalProcess undecan-2-one metabolic process The chemical reactions and pathways involving undecan-2-one. go.json undecan-2-one metabolism http://purl.obolibrary.org/obo/GO_1902790 GO:0034289 biolink:BiologicalProcess detection of maltose stimulus The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal. go.json perception of maltose stimulus http://purl.obolibrary.org/obo/GO_0034289 GO:0034280 biolink:MolecularActivity ent-sandaracopimaradiene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate. EC:4.2.3.29|KEGG_REACTION:R09120|MetaCyc:RXN-4884|RHEA:25536 go.json ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity|ent-pimaradiene synthase activity http://purl.obolibrary.org/obo/GO_0034280 GO:0034281 biolink:MolecularActivity ent-isokaurene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate. go.json http://purl.obolibrary.org/obo/GO_0034281 GO:0034282 biolink:MolecularActivity ent-pimara-8(14),15-diene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate. EC:4.2.3.30|KEGG_REACTION:R09121|MetaCyc:RXN-7788|RHEA:25540 go.json ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity|ent-pimaradiene synthase activity http://purl.obolibrary.org/obo/GO_0034282 GO:0034283 biolink:MolecularActivity syn-stemod-13(17)-ene synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate. EC:4.2.3.34|KEGG_REACTION:R09116|MetaCyc:RXN-9291|RHEA:25556 go.json 9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity|exo-stemodene synthase activity|stemod-13(17)-ene synthase activity|stemodene synthase activity|syn-stemodene synthase activity http://purl.obolibrary.org/obo/GO_0034283 GO:0034284 biolink:BiologicalProcess response to monosaccharide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. go.json response to monosaccharide stimulus http://purl.obolibrary.org/obo/GO_0034284 GO:0034285 biolink:BiologicalProcess response to disaccharide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. go.json response to disaccharide stimulus http://purl.obolibrary.org/obo/GO_0034285 GO:1902799 biolink:BiologicalProcess regulation of phosphodiesterase I activity Any process that modulates the frequency, rate or extent of phosphodiesterase I activity. go.json regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|regulation of 5'-NPDase activity|regulation of 5'-PDE activity|regulation of 5'-PDase activity|regulation of 5'-exonuclease activity|regulation of 5'-nucleotide phosphodiesterase activity|regulation of 5'-phosphodiesterase activity|regulation of 5'NPDE activity|regulation of PDE I activity|regulation of alkaline phosphodiesterase activity|regulation of exonuclease I activity|regulation of nucleotide pyrophosphatase/phosphodiesterase I activity|regulation of oligonucleate 5'-nucleotidohydrolase activity|regulation of orthophosphoric diester phosphohydrolase activity|regulation of phosphodiesterase activity http://purl.obolibrary.org/obo/GO_1902799 gocheck_do_not_annotate GO:1902797 biolink:BiologicalProcess negative regulation of snoRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing. go.json down regulation of snoRNA processing|down-regulation of snoRNA processing|downregulation of snoRNA processing|inhibition of snoRNA processing http://purl.obolibrary.org/obo/GO_1902797 GO:1902798 biolink:BiologicalProcess positive regulation of snoRNA processing Any process that activates or increases the frequency, rate or extent of snoRNA processing. go.json activation of snoRNA processing|up regulation of snoRNA processing|up-regulation of snoRNA processing|upregulation of snoRNA processing http://purl.obolibrary.org/obo/GO_1902798 GO:1902795 biolink:BiologicalProcess siRNA-mediated facultative heterochromatin formation The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering RNA. go.json HOOD assembly|HOOD formation|heterochromatin domain assembly|heterochromatin domain formation|siRNA-dependent facultative heterochromatin assembly|siRNA-dependent facultative heterochromatin formation http://purl.obolibrary.org/obo/GO_1902795 GO:1902796 biolink:BiologicalProcess regulation of snoRNA processing Any process that modulates the frequency, rate or extent of snoRNA processing. go.json http://purl.obolibrary.org/obo/GO_1902796 GO:1902793 biolink:CellularComponent glutamate decarboxylase complex A protein complex which is capable of glutamate decarboxylase activity. go.json http://purl.obolibrary.org/obo/GO_1902793 GO:1902794 biolink:BiologicalProcess siRNA-independent facultative heterochromatin formation The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process independent of small interfering RNAs. go.json heterochromatin island assembly|heterochromatin island formation|siRNA-independent facultative heterochromatin assembly http://purl.obolibrary.org/obo/GO_1902794 GO:0034275 biolink:BiologicalProcess kynurenic acid metabolic process The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. go.json 4-hydroxyquinoline-2-carboxylic acid metabolic process|kynurenic acid metabolism http://purl.obolibrary.org/obo/GO_0034275 GO:0034276 biolink:BiologicalProcess kynurenic acid biosynthetic process The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. go.json 4-hydroxyquinoline-2-carboxylic acid biosynthetic process|kynurenic acid anabolism|kynurenic acid biosynthesis|kynurenic acid formation|kynurenic acid synthesis http://purl.obolibrary.org/obo/GO_0034276 GO:0034277 biolink:MolecularActivity ent-cassa-12,15-diene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate. EC:4.2.3.28|KEGG_REACTION:R09119|MetaCyc:RXN-4881|RHEA:25532 go.json ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity http://purl.obolibrary.org/obo/GO_0034277 GO:0034278 biolink:MolecularActivity stemar-13-ene synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate. EC:4.2.3.33|KEGG_REACTION:R09115|MetaCyc:RXN-4882|RHEA:25552 go.json 9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity http://purl.obolibrary.org/obo/GO_0034278 GO:0034279 biolink:MolecularActivity syn-pimara-7,15-diene synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate. EC:4.2.3.35|KEGG_REACTION:R09117|MetaCyc:RXN-4883|RHEA:25560 go.json 9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity http://purl.obolibrary.org/obo/GO_0034279 GO:0034270 biolink:CellularComponent Cvt complex A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p. go.json cytoplasm to vacuole targeting complex|cytoplasm-to-vacuole targeting complex http://purl.obolibrary.org/obo/GO_0034270 GO:0034271 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class III, type I A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p. go.json PtdIns-3-kinase complex I|autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex|phosphatidylinositol 3-kinase complex I http://purl.obolibrary.org/obo/GO_0034271 GO:0034272 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class III, type II A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p. go.json PtdIns-3-kinase complex II|phosphatidylinositol 3-kinase complex II http://purl.obolibrary.org/obo/GO_0034272 GO:0034273 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034273 GO:0034274 biolink:CellularComponent Atg12-Atg5-Atg16 complex A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. go.json http://purl.obolibrary.org/obo/GO_0034274 GO:0034264 biolink:BiologicalProcess isopentenyl adenine metabolic process The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine. go.json isopentenyl adenine metabolism|isopentenyladenine metabolic process http://purl.obolibrary.org/obo/GO_0034264 GO:0034265 biolink:BiologicalProcess isopentenyl adenine biosynthetic process The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine. go.json isopentenyl adenine anabolism|isopentenyl adenine biosynthesis|isopentenyl adenine formation|isopentenyl adenine synthesis|isopentenyladenine biosynthetic process http://purl.obolibrary.org/obo/GO_0034265 GO:0034266 biolink:BiologicalProcess isopentenyl adenine catabolic process The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine. go.json isopentenyl adenine breakdown|isopentenyl adenine catabolism|isopentenyl adenine degradation|isopentenyladenine catabolic process http://purl.obolibrary.org/obo/GO_0034266 GO:0034267 biolink:BiologicalProcess discadenine metabolic process The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. go.json discadenine metabolism http://purl.obolibrary.org/obo/GO_0034267 GO:0034268 biolink:BiologicalProcess discadenine biosynthetic process The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. go.json discadenine anabolism|discadenine biosynthesis|discadenine formation|discadenine synthesis http://purl.obolibrary.org/obo/GO_0034268 GO:0034269 biolink:BiologicalProcess discadenine catabolic process The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. go.json discadenine breakdown|discadenine catabolism|discadenine degradation http://purl.obolibrary.org/obo/GO_0034269 GO:0034260 biolink:BiologicalProcess negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. go.json down regulation of GTPase activity|down regulation of Rab GTPase activity|down regulation of Ras GTPase activity|down regulation of Rho GTPase activity|down regulation of regulation of Ran GTPase activity|down-regulation of GTPase activity|down-regulation of Rab GTPase activity|down-regulation of Ras GTPase activity|down-regulation of Rho GTPase activity|down-regulation of regulation of Ran GTPase activity|downregulation of GTPase activity|downregulation of Rab GTPase activity|downregulation of Ras GTPase activity|downregulation of Rho GTPase activity|downregulation of regulation of Ran GTPase activity|inhibition of GTPase activity|inhibition of Rab GTPase activity|inhibition of Ras GTPase activity|inhibition of Rho GTPase activity|inhibition of regulation of Ran GTPase activity|negative regulation of Rab GTPase activity|negative regulation of Ran GTPase activity|negative regulation of Ras GTPase activity|negative regulation of Rho GTPase activity|negative regulation of guanosinetriphosphatase activity http://purl.obolibrary.org/obo/GO_0034260 gocheck_do_not_annotate GO:0034261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034261 GO:0034262 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034262 GO:0034263 biolink:BiologicalProcess positive regulation of autophagy in response to ER overload The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy. go.json autophagy in response to ER stress|autophagy in response to endoplasmic reticulum overload http://purl.obolibrary.org/obo/GO_0034263 GO:0009297 biolink:BiologicalProcess pilus assembly The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. go.json fimbria assembly|fimbria biogenesis|fimbriae assembly|fimbriae biogenesis|fimbrial assembly|fimbrium assembly|fimbrium biogenesis|pilus biogenesis|pilus formation http://purl.obolibrary.org/obo/GO_0009297 GO:0010286 biolink:BiologicalProcess heat acclimation Any process that increases heat tolerance of an organism in response to high temperatures. go.json thermotolerance http://purl.obolibrary.org/obo/GO_0010286 GO:0034253 biolink:BiologicalProcess positive regulation of amide catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. go.json positive regulation of amide breakdown|positive regulation of amide catabolism|positive regulation of amide degradation|positive regulation of cellular amide catabolic process http://purl.obolibrary.org/obo/GO_0034253 GO:0009298 biolink:BiologicalProcess GDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. go.json GDP-mannose anabolism|GDP-mannose biosynthesis|GDP-mannose formation|GDP-mannose synthesis http://purl.obolibrary.org/obo/GO_0009298 GO:0034254 biolink:BiologicalProcess regulation of urea catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea. go.json regulation of urea breakdown|regulation of urea catabolism|regulation of urea degradation http://purl.obolibrary.org/obo/GO_0034254 GO:0010287 biolink:CellularComponent plastoglobule A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. go.json PG|plastoglobuli http://purl.obolibrary.org/obo/GO_0010287 GO:0009299 biolink:BiologicalProcess mRNA transcription The cellular synthesis of messenger RNA (mRNA) from a DNA template. go.json cellular mRNA transcription|mRNA biosynthesis|mRNA biosynthetic process|mRNA synthesis http://purl.obolibrary.org/obo/GO_0009299 GO:0034255 biolink:BiologicalProcess regulation of urea metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea. go.json regulation of urea metabolism http://purl.obolibrary.org/obo/GO_0034255 GO:0010284 biolink:MolecularActivity lariciresinol reductase activity Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+. MetaCyc:RXN-8679|MetaCyc:RXN-8684 go.json http://purl.obolibrary.org/obo/GO_0010284 GO:0034256 biolink:MolecularActivity chlorophyll(ide) b reductase activity Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+. EC:1.1.1.294|MetaCyc:RXN-7678 go.json Chl b reductase activity|chlorophyll b reductase activity|chlorophyllide b reductase activity http://purl.obolibrary.org/obo/GO_0034256 GO:0010285 biolink:MolecularActivity L,L-diaminopimelate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+. EC:2.6.1.83|KEGG_REACTION:R07613|MetaCyc:RXN-7737|RHEA:23988 go.json LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity|LL-DAP aminotransferase activity|LL-DAP-AT activity|LL-diaminopimelate aminotransferase activity|LL-diaminopimelate transaminase activity http://purl.obolibrary.org/obo/GO_0010285 GO:0034257 biolink:MolecularActivity nicotinamide riboside transmembrane transporter activity Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other. RHEA:33163 go.json http://purl.obolibrary.org/obo/GO_0034257 GO:0034258 biolink:BiologicalProcess nicotinamide riboside transport The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0034258 GO:0034259 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034259 GO:0010288 biolink:BiologicalProcess response to lead ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0010288 GO:0010289 biolink:BiologicalProcess homogalacturonan biosynthetic process The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. MetaCyc:PWY-1061 go.json http://purl.obolibrary.org/obo/GO_0010289 GO:0010282 biolink:CellularComponent senescence-associated vacuole A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast. go.json senescence associated vacuole http://purl.obolibrary.org/obo/GO_0010282 GO:0010283 biolink:MolecularActivity pinoresinol reductase activity Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+. MetaCyc:RXN-8678|MetaCyc:RXN-8683 go.json http://purl.obolibrary.org/obo/GO_0010283 GO:0034250 biolink:BiologicalProcess positive regulation of amide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. go.json positive regulation of amide metabolism|positive regulation of cellular amide metabolic process http://purl.obolibrary.org/obo/GO_0034250 GO:0010280 biolink:MolecularActivity UDP-L-rhamnose synthase activity Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O. MetaCyc:RXN-5482 go.json UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity http://purl.obolibrary.org/obo/GO_0010280 GO:0034251 biolink:BiologicalProcess regulation of amide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. go.json regulation of amide breakdown|regulation of amide catabolism|regulation of amide degradation|regulation of cellular amide catabolic process http://purl.obolibrary.org/obo/GO_0034251 GO:0034252 biolink:BiologicalProcess negative regulation of amide catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. go.json negative regulation of amide breakdown|negative regulation of amide catabolism|negative regulation of amide degradation|negative regulation of cellular amide catabolic process http://purl.obolibrary.org/obo/GO_0034252 GO:0010281 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010281 GO:0010297 biolink:MolecularActivity heteropolysaccharide binding Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue. go.json heteroglycan binding http://purl.obolibrary.org/obo/GO_0010297 GO:0034242 biolink:BiologicalProcess negative regulation of syncytium formation by plasma membrane fusion Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. go.json http://purl.obolibrary.org/obo/GO_0034242 GO:0010298 biolink:MolecularActivity dihydrocamalexic acid decarboxylase activity Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+. MetaCyc:RXN-8275|RHEA:34807 go.json http://purl.obolibrary.org/obo/GO_0010298 GO:0034243 biolink:BiologicalProcess regulation of transcription elongation by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. go.json regulation of RNA elongation from RNA polymerase II promoter|regulation of gene-specific transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0034243 GO:0034244 biolink:BiologicalProcess negative regulation of transcription elongation by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. go.json negative regulation of RNA elongation from RNA polymerase II promoter|negative regulation of gene-specific transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0034244 GO:0010295 biolink:MolecularActivity (+)-abscisic acid 8'-hydroxylase activity Catalysis of the reaction: (+)-abscisate + H+ + NADPH + O2 = (+)-8'-hydroxyabscisate + H2O + NADP+. EC:1.14.14.137|KEGG_REACTION:R07202|MetaCyc:1.14.13.93-RXN|RHEA:12897 go.json (+)-ABA 8'-hydroxylase activity|ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity|ABA 8'-hydroxylase activity|abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)|abscisic acid 8'-hydroxylase activity http://purl.obolibrary.org/obo/GO_0010295 GO:0034245 biolink:CellularComponent mitochondrial DNA-directed RNA polymerase complex A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form. go.json mitochondrial RNA polymerase complex|mitochondrial RNA polymerase holoenzyme complex http://purl.obolibrary.org/obo/GO_0034245 GO:0010296 biolink:MolecularActivity prenylcysteine methylesterase activity Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+. MetaCyc:RXN-8409|RHEA:48520 go.json http://purl.obolibrary.org/obo/GO_0010296 GO:0034246 biolink:MolecularActivity mitochondrial transcription factor activity Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. go.json mitochondrial DNA-binding transcription factor activity|mitochondrial RNA polymerase binding promoter specificity activity|mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity|mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity|mitochondrial RNA polymerase promoter specificity activity|mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding|mitochondrial polymerase transcription factor activity|mitochondrial sequence-specific DNA binding transcription factor activity|mitochondrial sequence-specific DNA-binding transcription factor activity|mitochondrial transcription initiation factor activity|sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity|transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding|transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding|transcription factor activity, mitochondrial proximal promoter sequence-specific binding http://purl.obolibrary.org/obo/GO_0034246 GO:0034247 biolink:BiologicalProcess snoRNA splicing The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA. go.json http://purl.obolibrary.org/obo/GO_0034247 GO:0010299 biolink:BiologicalProcess detoxification of cobalt ion Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion. go.json http://purl.obolibrary.org/obo/GO_0010299 GO:0034248 biolink:BiologicalProcess regulation of amide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. go.json regulation of amide metabolism|regulation of cellular amide metabolic process http://purl.obolibrary.org/obo/GO_0034248 GO:0034249 biolink:BiologicalProcess negative regulation of amide metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. go.json negative regulation of amide metabolism|negative regulation of cellular amide metabolic process http://purl.obolibrary.org/obo/GO_0034249 GO:0010290 biolink:MolecularActivity chlorophyll catabolite transmembrane transporter activity Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0010290 GO:0010293 biolink:MolecularActivity abscisic aldehyde oxidase activity Catalysis of the reaction: (+)-abscisic aldehyde + H2O + O2 = abscisate + H2O2 + H+. EC:1.2.3.14|KEGG_REACTION:R06957|MetaCyc:1.2.3.14-RXN|RHEA:20529 go.json AAO3|AOdelta|abscisic-aldehyde oxidase activity|abscisic-aldehyde:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0010293 GO:0010294 biolink:MolecularActivity abscisic acid glucosyltransferase activity Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP. MetaCyc:RXN-8155|RHEA:31031 go.json http://purl.obolibrary.org/obo/GO_0010294 GO:0034240 biolink:BiologicalProcess negative regulation of macrophage fusion Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion. go.json http://purl.obolibrary.org/obo/GO_0034240 GO:0010291 biolink:MolecularActivity carotene beta-ring hydroxylase activity Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene. go.json beta-carotene hydroxylase activity http://purl.obolibrary.org/obo/GO_0010291 GO:0034241 biolink:BiologicalProcess positive regulation of macrophage fusion Any process that activates or increases the frequency, rate or extent of macrophage fusion. go.json http://purl.obolibrary.org/obo/GO_0034241 GO:0010292 biolink:MolecularActivity GTP:GDP antiporter activity Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out). go.json http://purl.obolibrary.org/obo/GO_0010292 GO:0034239 biolink:BiologicalProcess regulation of macrophage fusion Any process that modulates the frequency, rate or extent of macrophage fusion. go.json http://purl.obolibrary.org/obo/GO_0034239 GO:0009280 biolink:CellularComponent obsolete cell wall inner membrane OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus. go.json cell wall inner membrane|cytoplasmic membrane True http://purl.obolibrary.org/obo/GO_0009280 GO:0009281 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009281 GO:0009282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009282 GO:0009283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009283 GO:0009284 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009284 GO:0009285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009285 GO:0009275 biolink:CellularComponent Gram-positive-bacterium-type cell wall A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria. go.json 20-80nm peptidoglycan-based cell wall|cell wall of Gram-positive Bacteria http://purl.obolibrary.org/obo/GO_0009275 GO:0034231 biolink:BiologicalProcess islet amyloid polypeptide processing The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP). go.json IAPP formation|IAPP processing|islet amyloid peptide formation|islet amyloid peptide processing|islet amyloid polypeptide formation http://purl.obolibrary.org/obo/GO_0034231 GO:0010264 biolink:BiologicalProcess myo-inositol hexakisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. go.json myo-inositol hexakisphosphate anabolism|myo-inositol hexakisphosphate biosynthesis|myo-inositol hexakisphosphate formation|myo-inositol hexakisphosphate synthesis|phytate biosynthesis|phytate biosynthetic process http://purl.obolibrary.org/obo/GO_0010264 GO:0009276 biolink:CellularComponent Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. go.json 1-2nm peptidoglycan-based cell wall|cell wall inner membrane http://purl.obolibrary.org/obo/GO_0009276 goslim_metagenomics GO:0034232 biolink:BiologicalProcess ascospore wall chitin catabolic process The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. go.json ascospore wall chitin breakdown|ascospore wall chitin catabolism|ascospore wall chitin degradation http://purl.obolibrary.org/obo/GO_0034232 GO:0010265 biolink:BiologicalProcess SCF complex assembly The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex. go.json http://purl.obolibrary.org/obo/GO_0010265 GO:0010262 biolink:BiologicalProcess somatic embryogenesis Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes. go.json http://purl.obolibrary.org/obo/GO_0010262 GO:0009277 biolink:CellularComponent fungal-type cell wall A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. go.json beta-glucan-containing cell wall|chitin- and beta-glucan-containing cell wall|chitin-containing cell wall http://purl.obolibrary.org/obo/GO_0009277 GO:0034233 biolink:BiologicalProcess regulation of cell wall chitin catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin. go.json regulation of cell wall chitin breakdown|regulation of cell wall chitin catabolism|regulation of cell wall chitin degradation http://purl.obolibrary.org/obo/GO_0034233 GO:0010263 biolink:BiologicalProcess tricyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings. go.json tricyclic triterpenoid anabolism|tricyclic triterpenoid biosynthesis|tricyclic triterpenoid formation|tricyclic triterpenoid synthesis http://purl.obolibrary.org/obo/GO_0010263 GO:0034234 biolink:BiologicalProcess regulation of ascospore wall chitin catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin. go.json regulation of ascospore wall chitin breakdown|regulation of ascospore wall chitin catabolism|regulation of ascospore wall chitin degradation http://purl.obolibrary.org/obo/GO_0034234 GO:0009278 biolink:CellularComponent obsolete murein sacculus OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria. go.json murein sacculus True http://purl.obolibrary.org/obo/GO_0009278 GO:0034235 biolink:MolecularActivity GPI anchor binding Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. go.json glycosylphosphatidylinositol binding http://purl.obolibrary.org/obo/GO_0034235 GO:0009279 biolink:CellularComponent cell outer membrane A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. go.json outer membrane of cell http://purl.obolibrary.org/obo/GO_0009279 prokaryote_subset GO:0010268 biolink:BiologicalProcess brassinosteroid homeostasis Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0010268 GO:0010269 biolink:BiologicalProcess response to selenium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. go.json http://purl.obolibrary.org/obo/GO_0010269 GO:0034236 biolink:MolecularActivity protein kinase A catalytic subunit binding Binding to one or both of the catalytic subunits of protein kinase A. go.json PKA catalytic subunit binding http://purl.obolibrary.org/obo/GO_0034236 GO:0010266 biolink:BiologicalProcess response to vitamin B1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. go.json response to thiamin|response to thiamine http://purl.obolibrary.org/obo/GO_0010266 GO:0034237 biolink:MolecularActivity protein kinase A regulatory subunit binding Binding to one or both of the regulatory subunits of protein kinase A. go.json PKA regulatory subunit binding|protein kinase A anchoring activity http://purl.obolibrary.org/obo/GO_0034237 GO:0010267 biolink:BiologicalProcess ta-siRNA processing A process leading to the generation of a functional trans-acting small interfering RNA (ta-siRNA). ta-siRNAs function like miRNAs to guide cleavage of target mRNAs. go.json RNA interference, production of ta-siRNAs|primary ta-siRNA processing|production of small RNA involved in gene silencing by RNA|production of ta-siRNAs involved in RNA interference http://purl.obolibrary.org/obo/GO_0010267 GO:0034238 biolink:BiologicalProcess macrophage fusion The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell. go.json http://purl.obolibrary.org/obo/GO_0034238 GO:0010260 biolink:BiologicalProcess obsolete animal organ senescence OBSOLETE. The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. go.json True http://purl.obolibrary.org/obo/GO_0010260 GO:0010261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010261 GO:0034230 biolink:BiologicalProcess enkephalin processing The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide. go.json enkephalin formation|peptide enkephalin formation|peptide enkephalin processing http://purl.obolibrary.org/obo/GO_0034230 GO:0034228 biolink:MolecularActivity ethanolamine transmembrane transporter activity Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. RHEA:32747 go.json 2-aminoethanol transmembrane transporter activity|ethanolamine permease activity|monoethanolamine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0034228 GO:0009290 biolink:BiologicalProcess DNA import into cell involved in transformation The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell. go.json DNA import into cell|DNA transport into cell during transformation|cellular DNA import during transformation|cellular DNA uptake http://purl.obolibrary.org/obo/GO_0009290 GO:0034229 biolink:BiologicalProcess ethanolamine transport The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. go.json 2-aminoethanol transport|monoethanolamine transport http://purl.obolibrary.org/obo/GO_0034229 GO:0009291 biolink:BiologicalProcess unidirectional conjugation The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells. Some or all of the chromosome(s) of the donor cell is transferred into the recipient cell. Wikipedia:Bacterial_conjugation go.json bacterial conjugation http://purl.obolibrary.org/obo/GO_0009291 goslim_pir GO:0009292 biolink:BiologicalProcess horizontal gene transfer The introduction of genetic information into a cell to create a genetically different individual, without production of new individuals. go.json genetic exchange|genetic transfer|lateral gene transfer http://purl.obolibrary.org/obo/GO_0009292 goslim_pir GO:0009293 biolink:BiologicalProcess transduction A type of horizontal gene transfer in which genetic material is introduced into a cell mediated by a virus. Wikipedia:Transduction_(genetics) go.json http://purl.obolibrary.org/obo/GO_0009293 GO:0009294 biolink:BiologicalProcess DNA-mediated transformation The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope. go.json DNA mediated transformation http://purl.obolibrary.org/obo/GO_0009294 GO:0009295 biolink:CellularComponent nucleoid The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. Wikipedia:Nucleoid go.json http://purl.obolibrary.org/obo/GO_0009295 GO:0009296 biolink:BiologicalProcess obsolete flagellum assembly OBSOLETE. The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. go.json flagella assembly|flagella biogenesis|flagellum assembly|flagellum biogenesis True http://purl.obolibrary.org/obo/GO_0009296 GO:0034220 biolink:BiologicalProcess monoatomic ion transmembrane transport A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. go.json ATP hydrolysis coupled ion transmembrane transport|ion membrane transport|ion transmembrane transport|transmembrane ion transport http://purl.obolibrary.org/obo/GO_0034220 GO:0010275 biolink:BiologicalProcess NAD(P)H dehydrogenase complex assembly The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool. go.json NAD(P)H dehydrogenase complex (plastoquinone) assembly http://purl.obolibrary.org/obo/GO_0010275 GO:0009286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009286 GO:0010276 biolink:MolecularActivity phytol kinase activity Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+. EC:2.7.1.182|MetaCyc:RXN-7683|RHEA:38055 go.json http://purl.obolibrary.org/obo/GO_0010276 GO:0009287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009287 GO:0034221 biolink:BiologicalProcess fungal-type cell wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells. go.json fungal-type cell wall chitin anabolism|fungal-type cell wall chitin biosynthesis|fungal-type cell wall chitin formation|fungal-type cell wall chitin synthesis http://purl.obolibrary.org/obo/GO_0034221 GO:0034222 biolink:BiologicalProcess regulation of cell wall chitin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall. go.json regulation of cell wall chitin metabolism http://purl.obolibrary.org/obo/GO_0034222 GO:0010273 biolink:BiologicalProcess detoxification of copper ion Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion. go.json http://purl.obolibrary.org/obo/GO_0010273 GO:0009288 biolink:CellularComponent bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. go.json flagellin-based flagellum http://purl.obolibrary.org/obo/GO_0009288 goslim_metagenomics|goslim_pir GO:0009289 biolink:CellularComponent pilus A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. Wikipedia:Pilus go.json fimbria|fimbriae|fimbrium|pili http://purl.obolibrary.org/obo/GO_0009289 goslim_pir GO:0034223 biolink:BiologicalProcess regulation of ascospore wall chitin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin. go.json regulation of ascospore wall chitin anabolism|regulation of ascospore wall chitin biosynthesis|regulation of ascospore wall chitin formation|regulation of ascospore wall chitin synthesis http://purl.obolibrary.org/obo/GO_0034223 GO:0010274 biolink:BiologicalProcess hydrotropism Growth or movement in a sessile organism toward or away from water, as of the roots of a plant. Wikipedia:Hydrotropism go.json http://purl.obolibrary.org/obo/GO_0010274 GO:0010279 biolink:MolecularActivity indole-3-acetic acid amido synthetase activity Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate. go.json IAA amido synthetase activity|IAA amino acid conjugate synthetase activity|IAA amino acid synthetase activity http://purl.obolibrary.org/obo/GO_0010279 GO:0034224 biolink:BiologicalProcess cellular response to zinc ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions. go.json cellular response to zinc ion limitation|cellular response to zinc starvation http://purl.obolibrary.org/obo/GO_0034224 GO:0034225 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions. go.json regulation of transcription from RNA polymerase II promoter in response to zinc deficiency|regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation True http://purl.obolibrary.org/obo/GO_0034225 GO:0010277 biolink:MolecularActivity chlorophyllide a oxygenase [overall] activity Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. EC:1.14.13.122|RHEA:30359 go.json CAO activity|chlorophyll a oxygenation activity|chlorophyll b synthesis activity|chlorophyll-b synthesis activity|chlorophyllide a:oxygen 7-oxidoreduction activity|chlorophyllide-a oxygenation activity http://purl.obolibrary.org/obo/GO_0010277 GO:0034226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034226 GO:0010278 biolink:CellularComponent chloroplast outer membrane translocon The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner. go.json http://purl.obolibrary.org/obo/GO_0010278 GO:0034227 biolink:BiologicalProcess tRNA thio-modification The addition a sulfur atom to a nucleotide in a tRNA molecule. go.json tRNA thiolation http://purl.obolibrary.org/obo/GO_0034227 GO:0010271 biolink:BiologicalProcess regulation of chlorophyll catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll. go.json http://purl.obolibrary.org/obo/GO_0010271 GO:0010272 biolink:BiologicalProcess response to silver ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0010272 GO:0010270 biolink:BiologicalProcess photosystem II oxygen evolving complex assembly The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ. go.json OEC (PSII) ASSEMBLY http://purl.obolibrary.org/obo/GO_0010270 GO:0048861 biolink:BiologicalProcess leukemia inhibitory factor signaling pathway The series of molecular signals initiated by the binding of a leukemia inhibitory factor to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json leukemia inhibitory factor signalling pathway http://purl.obolibrary.org/obo/GO_0048861 GO:0048862 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048862 GO:0048863 biolink:BiologicalProcess stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. Wikipedia:Stem_cell_differentiation go.json http://purl.obolibrary.org/obo/GO_0048863 GO:0048864 biolink:BiologicalProcess stem cell development The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. go.json http://purl.obolibrary.org/obo/GO_0048864 GO:0048865 biolink:BiologicalProcess stem cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell. go.json http://purl.obolibrary.org/obo/GO_0048865 GO:0048866 biolink:BiologicalProcess stem cell fate specification The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0048866 GO:0048867 biolink:BiologicalProcess stem cell fate determination The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0048867 GO:0048868 biolink:BiologicalProcess pollen tube development The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure. go.json http://purl.obolibrary.org/obo/GO_0048868 GO:0048860 biolink:BiologicalProcess glioblast division The process resulting in the physical partitioning and separation of a glioblast into daughter cells. go.json http://purl.obolibrary.org/obo/GO_0048860 GO:0048869 biolink:BiologicalProcess cellular developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. go.json http://purl.obolibrary.org/obo/GO_0048869 GO:0048872 biolink:BiologicalProcess homeostasis of number of cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. go.json cell population homeostasis|homeostasis of cell number http://purl.obolibrary.org/obo/GO_0048872 GO:1902708 biolink:BiologicalProcess response to plumbagin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus. go.json http://purl.obolibrary.org/obo/GO_1902708 GO:1902709 biolink:BiologicalProcess cellular response to plumbagin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus. go.json http://purl.obolibrary.org/obo/GO_1902709 GO:0048873 biolink:BiologicalProcess homeostasis of number of cells within a tissue Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. go.json http://purl.obolibrary.org/obo/GO_0048873 GO:1902706 biolink:BiologicalProcess obsolete hexose catabolic process to acetate OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to acetate. go.json acidogenesis|hexose breakdown to acetate|hexose catabolism to acetate|hexose degradation to acetate True http://purl.obolibrary.org/obo/GO_1902706 GO:0048874 biolink:BiologicalProcess host-mediated regulation of intestinal microbiota composition The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut. go.json homeostasis of number of cells in a free-living population|host-induced regulation of intestinal microbiota composition http://purl.obolibrary.org/obo/GO_0048874 GO:1902707 biolink:BiologicalProcess obsolete hexose catabolic process to ethanol OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to ethanol. go.json hexose breakdown to ethanol|hexose catabolism to ethanol|hexose degradation to ethanol|solventogenesis True http://purl.obolibrary.org/obo/GO_1902707 GO:0048875 biolink:BiologicalProcess obsolete chemical homeostasis within a tissue OBSOLETE. Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. go.json True http://purl.obolibrary.org/obo/GO_0048875 GO:1902704 biolink:BiologicalProcess obsolete hexose catabolic process to acetone OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to acetone. go.json hexose breakdown to acetone|hexose catabolic process to 2-propanone|hexose catabolism to acetone|hexose degradation to acetone|solventogenesis True http://purl.obolibrary.org/obo/GO_1902704 GO:0048876 biolink:BiologicalProcess obsolete chemical homeostasis within retina OBSOLETE. Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina. go.json True http://purl.obolibrary.org/obo/GO_0048876 GO:1902705 biolink:BiologicalProcess obsolete hexose catabolic process to butyrate OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to butyrate. go.json acidogenesis|hexose breakdown to butyrate|hexose catabolism to butyrate|hexose degradation to butyrate True http://purl.obolibrary.org/obo/GO_1902705 GO:0048877 biolink:BiologicalProcess homeostasis of number of retina cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina. go.json http://purl.obolibrary.org/obo/GO_0048877 GO:1902702 biolink:BiologicalProcess obsolete hexose catabolic process to propan-2-ol OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol. go.json hexose breakdown to propan-2-ol|hexose catabolic process to isopropanol|hexose catabolic process to isopropyl alcohol|hexose catabolism to propan-2-ol|hexose degradation to propan-2-ol|solventogenesis True http://purl.obolibrary.org/obo/GO_1902702 GO:0048878 biolink:BiologicalProcess chemical homeostasis Any biological process involved in the maintenance of an internal steady state of a chemical. go.json http://purl.obolibrary.org/obo/GO_0048878 goslim_drosophila GO:1902703 biolink:BiologicalProcess obsolete hexose catabolic process to butan-1-ol OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to butan-1-ol. go.json hexose breakdown to butan-1-ol|hexose catabolic process to 1-butanol|hexose catabolic process to butanol|hexose catabolism to butan-1-ol|hexose degradation to butan-1-ol|solventogenesis True http://purl.obolibrary.org/obo/GO_1902703 GO:1902700 biolink:BiologicalProcess pentose catabolic process to butan-1-ol The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol. go.json pentose breakdown to butan-1-ol|pentose catabolic process to 1-butanol|pentose catabolic process to butanol|pentose catabolism to butan-1-ol|pentose degradation to butan-1-ol|solventogenesis http://purl.obolibrary.org/obo/GO_1902700 GO:1902701 biolink:BiologicalProcess pentose catabolic process to propan-2-ol The chemical reactions and pathways resulting in the breakdown of pentose to propan-2-ol. go.json pentose breakdown to propan-2-ol|pentose catabolic process to isopropanol|pentose catabolic process to isopropyl alcohol|pentose catabolism to propan-2-ol|pentose degradation to propan-2-ol|solventogenesis http://purl.obolibrary.org/obo/GO_1902701 GO:0048870 biolink:BiologicalProcess cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. go.json cell locomotion|cell movement|movement of a cell http://purl.obolibrary.org/obo/GO_0048870 goslim_chembl|goslim_drosophila|goslim_generic|prokaryote_subset GO:0048871 biolink:BiologicalProcess multicellular organismal-level homeostasis Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0048871 GO:1902719 biolink:BiologicalProcess obsolete extracellular sequestering of copper ion OBSOLETE. The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system. go.json extracellular sequestering of copper ion True http://purl.obolibrary.org/obo/GO_1902719 GO:0048883 biolink:BiologicalProcess neuromast primordium migration The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop. go.json lateral line primordium migration http://purl.obolibrary.org/obo/GO_0048883 GO:0048884 biolink:BiologicalProcess neuromast development The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals. go.json http://purl.obolibrary.org/obo/GO_0048884 GO:0048885 biolink:BiologicalProcess neuromast deposition The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line. go.json http://purl.obolibrary.org/obo/GO_0048885 GO:1902717 biolink:BiologicalProcess obsolete sequestering of iron ion OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of iron ion. go.json sequestering of iron ion True http://purl.obolibrary.org/obo/GO_1902717 GO:1902718 biolink:BiologicalProcess obsolete sequestering of copper ion OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of copper ion. go.json sequestering of copper ion True http://purl.obolibrary.org/obo/GO_1902718 GO:0048886 biolink:BiologicalProcess neuromast hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. go.json http://purl.obolibrary.org/obo/GO_0048886 GO:1902715 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902715 GO:0048887 biolink:BiologicalProcess cupula development The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. go.json http://purl.obolibrary.org/obo/GO_0048887 GO:1902716 biolink:CellularComponent cell cortex of growing cell tip Any cell cortex that is part of a growing cell tip. go.json cell cortex of growing cell end http://purl.obolibrary.org/obo/GO_1902716 GO:0048888 biolink:BiologicalProcess neuromast mantle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. go.json http://purl.obolibrary.org/obo/GO_0048888 GO:0048889 biolink:BiologicalProcess neuromast support cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. go.json http://purl.obolibrary.org/obo/GO_0048889 GO:1902713 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902713 GO:1902714 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902714 GO:1902711 biolink:CellularComponent GABA-A receptor complex A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor). go.json http://purl.obolibrary.org/obo/GO_1902711 GO:1902712 biolink:CellularComponent G protein-coupled GABA receptor complex A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2. go.json G-protein coupled GABA receptor complex http://purl.obolibrary.org/obo/GO_1902712 GO:1902710 biolink:CellularComponent GABA receptor complex A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor. go.json gamma-aminobutyric acid receptor complex http://purl.obolibrary.org/obo/GO_1902710 GO:0048880 biolink:BiologicalProcess sensory system development The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048880 GO:0048881 biolink:BiologicalProcess mechanosensory lateral line system development The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. go.json LL system development http://purl.obolibrary.org/obo/GO_0048881 GO:0048882 biolink:BiologicalProcess lateral line development The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear. go.json LL development http://purl.obolibrary.org/obo/GO_0048882 GO:0048894 biolink:BiologicalProcess efferent axon development in a lateral line nerve The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048894 GO:0048895 biolink:BiologicalProcess lateral line nerve glial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048895 GO:0048896 biolink:BiologicalProcess lateral line nerve glial cell migration The movement of a glial cell along the axons in a lateral line nerve. go.json glial cell migration in lateral line nerve http://purl.obolibrary.org/obo/GO_0048896 GO:1902728 biolink:BiologicalProcess positive regulation of growth factor dependent skeletal muscle satellite cell proliferation Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. go.json http://purl.obolibrary.org/obo/GO_1902728 GO:1902729 biolink:BiologicalProcess negative regulation of proteoglycan biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. go.json down regulation of proteoglycan anabolism|down regulation of proteoglycan biosynthesis|down regulation of proteoglycan biosynthetic process|down regulation of proteoglycan formation|down regulation of proteoglycan synthesis|down-regulation of proteoglycan anabolism|down-regulation of proteoglycan biosynthesis|down-regulation of proteoglycan biosynthetic process|down-regulation of proteoglycan formation|down-regulation of proteoglycan synthesis|downregulation of proteoglycan anabolism|downregulation of proteoglycan biosynthesis|downregulation of proteoglycan biosynthetic process|downregulation of proteoglycan formation|downregulation of proteoglycan synthesis|inhibition of proteoglycan anabolism|inhibition of proteoglycan biosynthesis|inhibition of proteoglycan biosynthetic process|inhibition of proteoglycan formation|inhibition of proteoglycan synthesis|negative regulation of proteoglycan anabolism|negative regulation of proteoglycan biosynthesis|negative regulation of proteoglycan formation|negative regulation of proteoglycan synthesis http://purl.obolibrary.org/obo/GO_1902729 GO:0048897 biolink:BiologicalProcess myelination of lateral line nerve axons The formation of compact myelin sheaths around the axons of a lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048897 GO:1902726 biolink:BiologicalProcess positive regulation of skeletal muscle satellite cell differentiation Any process that activates or increases the frequency, rate or extent of satellite cell differentiation. go.json activation of satellite cell differentiation|up regulation of satellite cell differentiation|up-regulation of satellite cell differentiation|upregulation of satellite cell differentiation http://purl.obolibrary.org/obo/GO_1902726 GO:0048898 biolink:BiologicalProcess anterior lateral line system development The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. go.json ALL system development http://purl.obolibrary.org/obo/GO_0048898 GO:1902727 biolink:BiologicalProcess negative regulation of growth factor dependent skeletal muscle satellite cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. go.json http://purl.obolibrary.org/obo/GO_1902727 GO:0048899 biolink:BiologicalProcess anterior lateral line development The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear. go.json anterior LL development http://purl.obolibrary.org/obo/GO_0048899 GO:1902724 biolink:BiologicalProcess positive regulation of skeletal muscle satellite cell proliferation Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation. go.json activation of satellite cell proliferation|up regulation of satellite cell proliferation|up-regulation of satellite cell proliferation|upregulation of satellite cell proliferation http://purl.obolibrary.org/obo/GO_1902724 GO:1902725 biolink:BiologicalProcess negative regulation of satellite cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation. go.json down regulation of satellite cell differentiation|down-regulation of satellite cell differentiation|downregulation of satellite cell differentiation|inhibition of satellite cell differentiation http://purl.obolibrary.org/obo/GO_1902725 GO:1902722 biolink:BiologicalProcess positive regulation of prolactin secretion Any process that activates or increases the frequency, rate or extent of prolactin secretion. go.json activation of prolactin secretion|up regulation of prolactin secretion|up-regulation of prolactin secretion|upregulation of prolactin secretion http://purl.obolibrary.org/obo/GO_1902722 GO:1902723 biolink:BiologicalProcess negative regulation of skeletal muscle satellite cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation. go.json down regulation of satellite cell proliferation|down-regulation of satellite cell proliferation|downregulation of satellite cell proliferation|inhibition of satellite cell proliferation http://purl.obolibrary.org/obo/GO_1902723 GO:1902720 biolink:BiologicalProcess obsolete intracellular sequestering of copper ion OBSOLETE. The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system. go.json intracellular sequestering of copper ion True http://purl.obolibrary.org/obo/GO_1902720 GO:1902721 biolink:BiologicalProcess negative regulation of prolactin secretion Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion. go.json down regulation of prolactin secretion|down-regulation of prolactin secretion|downregulation of prolactin secretion|inhibition of prolactin secretion http://purl.obolibrary.org/obo/GO_1902721 GO:0048890 biolink:BiologicalProcess lateral line ganglion development The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear. go.json gLL ganglion development http://purl.obolibrary.org/obo/GO_0048890 GO:0048891 biolink:BiologicalProcess lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron. go.json gLL neuron differentiation http://purl.obolibrary.org/obo/GO_0048891 GO:0048892 biolink:BiologicalProcess lateral line nerve development The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. go.json nLL development http://purl.obolibrary.org/obo/GO_0048892 GO:0048893 biolink:BiologicalProcess afferent axon development in lateral line nerve The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve. go.json http://purl.obolibrary.org/obo/GO_0048893 GO:1902739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902739 GO:1902737 biolink:CellularComponent dendritic filopodium A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines. go.json dendrite filopodium http://purl.obolibrary.org/obo/GO_1902737 GO:1902738 biolink:BiologicalProcess regulation of chondrocyte differentiation involved in endochondral bone morphogenesis Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. go.json http://purl.obolibrary.org/obo/GO_1902738 GO:1902735 biolink:BiologicalProcess negative regulation of receptor-mediated virion attachment to host cell Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated virion attachment to host cell. go.json down regulation of receptor-mediated virion attachment to host cell|down regulation of virion attachment, binding of host cell surface receptor|down-regulation of receptor-mediated virion attachment to host cell|down-regulation of virion attachment, binding of host cell surface receptor|downregulation of receptor-mediated virion attachment to host cell|downregulation of virion attachment, binding of host cell surface receptor|inhibition of receptor-mediated virion attachment to host cell|inhibition of virion attachment, binding of host cell surface receptor|negative regulation of virion attachment, binding of host cell surface receptor http://purl.obolibrary.org/obo/GO_1902735 GO:1902736 biolink:BiologicalProcess positive regulation of receptor-mediated virion attachment to host cell Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell. go.json activation of receptor-mediated virion attachment to host cell|activation of virion attachment, binding of host cell surface receptor|positive regulation of virion attachment, binding of host cell surface receptor|up regulation of receptor-mediated virion attachment to host cell|up regulation of virion attachment, binding of host cell surface receptor|up-regulation of receptor-mediated virion attachment to host cell|up-regulation of virion attachment, binding of host cell surface receptor|upregulation of receptor-mediated virion attachment to host cell|upregulation of virion attachment, binding of host cell surface receptor http://purl.obolibrary.org/obo/GO_1902736 GO:1902733 biolink:BiologicalProcess regulation of growth plate cartilage chondrocyte differentiation Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage. go.json http://purl.obolibrary.org/obo/GO_1902733 GO:1902734 biolink:BiologicalProcess regulation of receptor-mediated virion attachment to host cell Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell. go.json regulation of virion attachment, binding of host cell surface receptor http://purl.obolibrary.org/obo/GO_1902734 GO:1902731 biolink:BiologicalProcess negative regulation of chondrocyte proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. go.json down regulation of cartilage cell proliferation|down regulation of chondrocyte cell proliferation|down regulation of chondrocyte proliferation|down-regulation of cartilage cell proliferation|down-regulation of chondrocyte cell proliferation|down-regulation of chondrocyte proliferation|downregulation of cartilage cell proliferation|downregulation of chondrocyte cell proliferation|downregulation of chondrocyte proliferation|inhibition of cartilage cell proliferation|inhibition of chondrocyte cell proliferation|inhibition of chondrocyte proliferation|negative regulation of cartilage cell proliferation|negative regulation of chondrocyte cell proliferation http://purl.obolibrary.org/obo/GO_1902731 GO:1902732 biolink:BiologicalProcess positive regulation of chondrocyte proliferation Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. go.json activation of cartilage cell proliferation|activation of chondrocyte cell proliferation|activation of chondrocyte proliferation|positive regulation of cartilage cell proliferation|positive regulation of chondrocyte cell proliferation|up regulation of cartilage cell proliferation|up regulation of chondrocyte cell proliferation|up regulation of chondrocyte proliferation|up-regulation of cartilage cell proliferation|up-regulation of chondrocyte cell proliferation|up-regulation of chondrocyte proliferation|upregulation of cartilage cell proliferation|upregulation of chondrocyte cell proliferation|upregulation of chondrocyte proliferation http://purl.obolibrary.org/obo/GO_1902732 GO:1902730 biolink:BiologicalProcess positive regulation of proteoglycan biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. go.json activation of proteoglycan anabolism|activation of proteoglycan biosynthesis|activation of proteoglycan biosynthetic process|activation of proteoglycan formation|activation of proteoglycan synthesis|positive regulation of proteoglycan anabolism|positive regulation of proteoglycan biosynthesis|positive regulation of proteoglycan formation|positive regulation of proteoglycan synthesis|up regulation of proteoglycan anabolism|up regulation of proteoglycan biosynthesis|up regulation of proteoglycan biosynthetic process|up regulation of proteoglycan formation|up regulation of proteoglycan synthesis|up-regulation of proteoglycan anabolism|up-regulation of proteoglycan biosynthesis|up-regulation of proteoglycan biosynthetic process|up-regulation of proteoglycan formation|up-regulation of proteoglycan synthesis|upregulation of proteoglycan anabolism|upregulation of proteoglycan biosynthesis|upregulation of proteoglycan biosynthetic process|upregulation of proteoglycan formation|upregulation of proteoglycan synthesis http://purl.obolibrary.org/obo/GO_1902730 GO:1902748 biolink:BiologicalProcess positive regulation of lens fiber cell differentiation Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation. go.json activation of lens fiber cell differentiation|activation of lens fibre cell differentiation|positive regulation of lens fibre cell differentiation|up regulation of lens fiber cell differentiation|up regulation of lens fibre cell differentiation|up-regulation of lens fiber cell differentiation|up-regulation of lens fibre cell differentiation|upregulation of lens fiber cell differentiation|upregulation of lens fibre cell differentiation http://purl.obolibrary.org/obo/GO_1902748 GO:1902749 biolink:BiologicalProcess regulation of cell cycle G2/M phase transition Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. go.json http://purl.obolibrary.org/obo/GO_1902749 GO:1902746 biolink:BiologicalProcess regulation of lens fiber cell differentiation Any process that modulates the frequency, rate or extent of lens fiber cell differentiation. go.json regulation of lens fibre cell differentiation http://purl.obolibrary.org/obo/GO_1902746 GO:1902747 biolink:BiologicalProcess negative regulation of lens fiber cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation. go.json down regulation of lens fiber cell differentiation|down regulation of lens fibre cell differentiation|down-regulation of lens fiber cell differentiation|down-regulation of lens fibre cell differentiation|downregulation of lens fiber cell differentiation|downregulation of lens fibre cell differentiation|inhibition of lens fiber cell differentiation|inhibition of lens fibre cell differentiation|negative regulation of lens fibre cell differentiation http://purl.obolibrary.org/obo/GO_1902747 GO:1902744 biolink:BiologicalProcess negative regulation of lamellipodium organization Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization. go.json down regulation of lamellipodium organization|down-regulation of lamellipodium organization|downregulation of lamellipodium organization|inhibition of lamellipodium organization http://purl.obolibrary.org/obo/GO_1902744 GO:1902745 biolink:BiologicalProcess positive regulation of lamellipodium organization Any process that activates or increases the frequency, rate or extent of lamellipodium organization. go.json activation of lamellipodium organization|up regulation of lamellipodium organization|up-regulation of lamellipodium organization|upregulation of lamellipodium organization http://purl.obolibrary.org/obo/GO_1902745 GO:1902742 biolink:BiologicalProcess apoptotic process involved in development Any apoptotic process that is involved in anatomical structure development. go.json activation of apoptosis involved in anatomical structure development|activation of apoptosis involved in development of an anatomical structure|apoptosis activator activity involved in anatomical structure development|apoptosis activator activity involved in development of an anatomical structure|apoptosis involved in anatomical structure development|apoptosis involved in development of an anatomical structure|apoptosis signaling involved in anatomical structure development|apoptosis signaling involved in development of an anatomical structure|apoptotic cell death involved in anatomical structure development|apoptotic cell death involved in development of an anatomical structure|apoptotic process involved in anatomical structure development|apoptotic process involved in development of an anatomical structure|apoptotic program involved in anatomical structure development|apoptotic program involved in development of an anatomical structure|apoptotic programmed cell death involved in anatomical structure development|apoptotic programmed cell death involved in development of an anatomical structure|commitment to apoptosis involved in anatomical structure development|commitment to apoptosis involved in development of an anatomical structure|induction of apoptosis by p53 involved in anatomical structure development|induction of apoptosis by p53 involved in development of an anatomical structure|induction of apoptosis involved in anatomical structure development|induction of apoptosis involved in development of an anatomical structure|programmed cell death by apoptosis involved in anatomical structure development|programmed cell death by apoptosis involved in development of an anatomical structure|signaling (initiator) caspase activity involved in anatomical structure development|signaling (initiator) caspase activity involved in development of an anatomical structure|type I programmed cell death involved in anatomical structure development|type I programmed cell death involved in development of an anatomical structure http://purl.obolibrary.org/obo/GO_1902742 GO:1902743 biolink:BiologicalProcess regulation of lamellipodium organization Any process that modulates the frequency, rate or extent of lamellipodium organization. go.json http://purl.obolibrary.org/obo/GO_1902743 GO:1902740 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902740 GO:1902741 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902741 GO:1902759 biolink:BiologicalProcess Mo(VI)-molybdopterin cytosine dinucleotide metabolic process The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide. go.json Mo(VI)-molybdopterin cytosine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_1902759 GO:1902757 biolink:BiologicalProcess bis(molybdopterin guanine dinucleotide)molybdenum metabolic process The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum. go.json bis(molybdopterin guanine dinucleotide)molybdenum metabolism http://purl.obolibrary.org/obo/GO_1902757 GO:1902758 biolink:BiologicalProcess bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum. MetaCyc:PWY-5964 go.json bis(molybdopterin guanine dinucleotide)molybdenum anabolism|bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis|bis(molybdopterin guanine dinucleotide)molybdenum formation|bis(molybdopterin guanine dinucleotide)molybdenum synthesis|bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process http://purl.obolibrary.org/obo/GO_1902758 GO:1902755 biolink:BiologicalProcess sulfurated eukaryotic molybdenum cofactor(2-) metabolic process The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-). go.json sulfurated eukaryotic molybdenum cofactor(2-) metabolism http://purl.obolibrary.org/obo/GO_1902755 GO:1902756 biolink:BiologicalProcess sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-). MetaCyc:PWY-6476|Reactome:R-HSA-947581 go.json sulfurated eukaryotic molybdenum cofactor(2-) anabolism|sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis|sulfurated eukaryotic molybdenum cofactor(2-) formation|sulfurated eukaryotic molybdenum cofactor(2-) synthesis http://purl.obolibrary.org/obo/GO_1902756 GO:1902753 biolink:BiologicalProcess negative regulation of renal amino acid absorption Any process that stops, prevents or reduces the frequency, rate or extent of renal amino acid absorption. go.json down regulation of renal amino acid absorption|down-regulation of renal amino acid absorption|downregulation of renal amino acid absorption|inhibition of renal amino acid absorption http://purl.obolibrary.org/obo/GO_1902753 GO:1902754 biolink:BiologicalProcess positive regulation of renal amino acid absorption Any process that activates or increases the frequency, rate or extent of renal amino acid absorption. go.json activation of renal amino acid absorption|up regulation of renal amino acid absorption|up-regulation of renal amino acid absorption|upregulation of renal amino acid absorption http://purl.obolibrary.org/obo/GO_1902754 GO:1902751 biolink:BiologicalProcess positive regulation of cell cycle G2/M phase transition Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. go.json activation of cell cycle G2/M phase transition|up regulation of cell cycle G2/M phase transition|up-regulation of cell cycle G2/M phase transition|upregulation of cell cycle G2/M phase transition http://purl.obolibrary.org/obo/GO_1902751 GO:1902752 biolink:BiologicalProcess regulation of renal amino acid absorption Any process that modulates the frequency, rate or extent of renal amino acid absorption. go.json http://purl.obolibrary.org/obo/GO_1902752 GO:1902750 biolink:BiologicalProcess negative regulation of cell cycle G2/M phase transition Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. go.json down regulation of cell cycle G2/M phase transition|down-regulation of cell cycle G2/M phase transition|downregulation of cell cycle G2/M phase transition|inhibition of cell cycle G2/M phase transition http://purl.obolibrary.org/obo/GO_1902750 GO:1902768 biolink:BiologicalProcess isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate The chemical reactions and pathways resulting in the formation of isoprenoid via 1-deoxy-D-xylulose 5-phosphate. go.json isoprenoid anabolism via 1-deoxy-D-xylulose 5-phosphate|isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate|isoprenoid formation via 1-deoxy-D-xylulose 5-phosphate|isoprenoid synthesis via 1-deoxy-D-xylulose 5-phosphate http://purl.obolibrary.org/obo/GO_1902768 GO:1902769 biolink:BiologicalProcess regulation of choline O-acetyltransferase activity Any process that modulates the frequency, rate or extent of choline O-acetyltransferase activity. go.json regulation of CHOACTase activity|regulation of acetyl-CoA:choline O-acetyltransferase activity|regulation of choline acetylase activity|regulation of choline acetyltransferase activity http://purl.obolibrary.org/obo/GO_1902769 gocheck_do_not_annotate GO:1902766 biolink:BiologicalProcess skeletal muscle satellite cell migration The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells. go.json http://purl.obolibrary.org/obo/GO_1902766 GO:1902767 biolink:BiologicalProcess isoprenoid biosynthetic process via mevalonate The chemical reactions and pathways resulting in the formation of isoprenoid via mevalonate. go.json isoprenoid anabolism via mevalonate|isoprenoid biosynthesis via mevalonate|isoprenoid formation via mevalonate|isoprenoid synthesis via mevalonate http://purl.obolibrary.org/obo/GO_1902767 GO:1902764 biolink:BiologicalProcess positive regulation of embryonic skeletal joint development Any process that activates or increases the frequency, rate or extent of embryonic skeletal joint development. go.json activation of embryonic skeletal joint development|up regulation of embryonic skeletal joint development|up-regulation of embryonic skeletal joint development|upregulation of embryonic skeletal joint development http://purl.obolibrary.org/obo/GO_1902764 GO:1902765 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902765 GO:1902762 biolink:BiologicalProcess regulation of embryonic skeletal joint development Any process that modulates the frequency, rate or extent of embryonic skeletal joint development. go.json http://purl.obolibrary.org/obo/GO_1902762 GO:1902763 biolink:BiologicalProcess negative regulation of embryonic skeletal joint development Any process that stops, prevents or reduces the frequency, rate or extent of embryonic skeletal joint development. go.json down regulation of embryonic skeletal joint development|down-regulation of embryonic skeletal joint development|downregulation of embryonic skeletal joint development|inhibition of embryonic skeletal joint development http://purl.obolibrary.org/obo/GO_1902763 GO:1902760 biolink:BiologicalProcess Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide. MetaCyc:PWY-6476 go.json Mo(VI)-molybdopterin cytosine dinucleotide anabolism|Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis|Mo(VI)-molybdopterin cytosine dinucleotide formation|Mo(VI)-molybdopterin cytosine dinucleotide synthesis|Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process http://purl.obolibrary.org/obo/GO_1902760 GO:1902761 biolink:BiologicalProcess positive regulation of chondrocyte development Any process that activates or increases the frequency, rate or extent of chondrocyte development. go.json activation of chondrocyte development|up regulation of chondrocyte development|up-regulation of chondrocyte development|upregulation of chondrocyte development http://purl.obolibrary.org/obo/GO_1902761 GO:1902770 biolink:BiologicalProcess negative regulation of choline O-acetyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity. go.json down regulation of CHOACTase activity|down regulation of acetyl-CoA:choline O-acetyltransferase activity|down regulation of choline O-acetyltransferase activity|down regulation of choline acetylase activity|down regulation of choline acetyltransferase activity|down-regulation of CHOACTase activity|down-regulation of acetyl-CoA:choline O-acetyltransferase activity|down-regulation of choline O-acetyltransferase activity|down-regulation of choline acetylase activity|down-regulation of choline acetyltransferase activity|downregulation of CHOACTase activity|downregulation of acetyl-CoA:choline O-acetyltransferase activity|downregulation of choline O-acetyltransferase activity|downregulation of choline acetylase activity|downregulation of choline acetyltransferase activity|inhibition of CHOACTase activity|inhibition of acetyl-CoA:choline O-acetyltransferase activity|inhibition of choline O-acetyltransferase activity|inhibition of choline acetylase activity|inhibition of choline acetyltransferase activity|negative regulation of CHOACTase activity|negative regulation of acetyl-CoA:choline O-acetyltransferase activity|negative regulation of choline acetylase activity|negative regulation of choline acetyltransferase activity http://purl.obolibrary.org/obo/GO_1902770 gocheck_do_not_annotate GO:0010404 biolink:BiologicalProcess cell wall hydroxyproline-rich glycoprotein metabolic process The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates. go.json cell wall hydroxyproline-rich glycoprotein metabolism http://purl.obolibrary.org/obo/GO_0010404 GO:0010405 biolink:BiologicalProcess arabinogalactan protein metabolic process The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures. go.json arabinogalactan protein metabolism http://purl.obolibrary.org/obo/GO_0010405 GO:0010402 biolink:BiologicalProcess pectic arabinan metabolic process The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I. go.json pectic arabinan metabolism http://purl.obolibrary.org/obo/GO_0010402 GO:0010403 biolink:BiologicalProcess pectic arabinogalactan I metabolic process The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I. go.json pectic arabinogalactan I metabolism http://purl.obolibrary.org/obo/GO_0010403 GO:0010408 biolink:BiologicalProcess fasciclin-like arabinogalactan protein metabolic process The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain. go.json fasciclin-like arabinogalactan protein metabolism http://purl.obolibrary.org/obo/GO_0010408 GO:0010409 biolink:BiologicalProcess extensin metabolic process The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated. go.json extensin metabolism http://purl.obolibrary.org/obo/GO_0010409 GO:0010406 biolink:BiologicalProcess classical arabinogalactan protein metabolic process The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored. go.json classical-arabinogalactan protein metabolism http://purl.obolibrary.org/obo/GO_0010406 GO:0010407 biolink:BiologicalProcess non-classical arabinogalactan protein metabolic process The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains. go.json non-classical arabinogalactan protein metabolism http://purl.obolibrary.org/obo/GO_0010407 GO:0009410 biolink:BiologicalProcess response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json drug resistance|drug susceptibility/resistance|response to drug http://purl.obolibrary.org/obo/GO_0009410 goslim_candida GO:0009411 biolink:BiologicalProcess response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. go.json response to UV light stimulus|response to UV radiation stimulus|response to ultraviolet light stimulus|response to ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_0009411 GO:0010400 biolink:BiologicalProcess rhamnogalacturonan I side chain metabolic process The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I. go.json rhamnogalacturonan I side chain metabolism http://purl.obolibrary.org/obo/GO_0010400 GO:0009412 biolink:BiologicalProcess obsolete response to heavy metal OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. go.json response to heavy metal True http://purl.obolibrary.org/obo/GO_0009412 GO:0010401 biolink:BiologicalProcess pectic galactan metabolic process The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I. go.json pectic galactan metabolism http://purl.obolibrary.org/obo/GO_0010401 GO:0009413 biolink:BiologicalProcess response to flooding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water. go.json http://purl.obolibrary.org/obo/GO_0009413 GO:0009414 biolink:BiologicalProcess response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. go.json drought tolerance|response to dehydration|response to drought|response to thirst http://purl.obolibrary.org/obo/GO_0009414 GO:0009415 biolink:BiologicalProcess response to water Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. go.json response to water stimulus http://purl.obolibrary.org/obo/GO_0009415 GO:0009416 biolink:BiologicalProcess response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. go.json http://purl.obolibrary.org/obo/GO_0009416 goslim_plant GO:0009417 biolink:CellularComponent obsolete fimbrin OBSOLETE. A class of proteins that are the subunit components of fimbria. go.json fimbrin True http://purl.obolibrary.org/obo/GO_0009417 GO:0009418 biolink:CellularComponent pilus shaft The long, slender, mid section of a pilus. go.json fimbrial shaft http://purl.obolibrary.org/obo/GO_0009418 GO:0009419 biolink:CellularComponent pilus tip The pointed extremity furthest from the cell of a pilus. go.json fimbrial tip http://purl.obolibrary.org/obo/GO_0009419 GO:0010415 biolink:BiologicalProcess unsubstituted mannan metabolic process The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units. go.json unsubstituted mannan metabolism http://purl.obolibrary.org/obo/GO_0010415 GO:0010416 biolink:BiologicalProcess arabinoxylan-containing compound metabolic process The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units. go.json arabinoxylan metabolic process|arabinoxylan metabolism http://purl.obolibrary.org/obo/GO_0010416 GO:0010413 biolink:BiologicalProcess glucuronoxylan metabolic process The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units. go.json glucuronoxylan metabolism http://purl.obolibrary.org/obo/GO_0010413 GO:0010414 biolink:BiologicalProcess glucuronoarabinoxylan metabolic process The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units. go.json glucuronoarabinoxylan metabolism http://purl.obolibrary.org/obo/GO_0010414 GO:0010419 biolink:BiologicalProcess rhamnogalacturonan II side chain metabolic process The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively. go.json rhamnogalacturonan II side chain metabolism http://purl.obolibrary.org/obo/GO_0010419 GO:0010417 biolink:BiologicalProcess glucuronoxylan biosynthetic process The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues. go.json glucuronoxylan anabolism|glucuronoxylan biosynthesis|glucuronoxylan formation|glucuronoxylan synthesis http://purl.obolibrary.org/obo/GO_0010417 GO:0010418 biolink:BiologicalProcess rhamnogalacturonan II backbone metabolic process The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues. go.json rhamnogalacturonan II backbone metabolism http://purl.obolibrary.org/obo/GO_0010418 GO:0009420 biolink:CellularComponent bacterial-type flagellum filament The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller. go.json flagellar filament|flagellin-based flagellum filament http://purl.obolibrary.org/obo/GO_0009420 GO:0009421 biolink:CellularComponent bacterial-type flagellum filament cap The proteinaceous structure at the distal tip of the bacterial-type flagellar filament. go.json flagellar filament cap|flagellin-based flagellum filament cap http://purl.obolibrary.org/obo/GO_0009421 GO:0010411 biolink:BiologicalProcess xyloglucan metabolic process The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. go.json xyloglucan metabolism http://purl.obolibrary.org/obo/GO_0010411 GO:0009422 biolink:CellularComponent bacterial-type flagellum hook-filament junction The region of the bacterial-type flagellum where the hook and filament meet. go.json flagellar hook-filament junction http://purl.obolibrary.org/obo/GO_0009422 GO:0009423 biolink:BiologicalProcess chorismate biosynthetic process The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds. MetaCyc:ARO-PWY go.json chorismate anabolism|chorismate biosynthesis|chorismate formation|chorismate synthesis|shikimate anabolism|shikimate biosynthesis|shikimate biosynthetic process|shikimate pathway|shikimate synthesis http://purl.obolibrary.org/obo/GO_0009423 GO:0010412 biolink:BiologicalProcess mannan metabolic process The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units. go.json mannan metabolism http://purl.obolibrary.org/obo/GO_0010412 GO:0009424 biolink:CellularComponent bacterial-type flagellum hook The portion of the bacterial-type flagellum that connects the filament to the basal body. go.json flagellar hook|flagellin-based flagellum hook http://purl.obolibrary.org/obo/GO_0009424 GO:0009425 biolink:CellularComponent bacterial-type flagellum basal body One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. go.json flagellar basal body|flagellin-based flagellum basal body http://purl.obolibrary.org/obo/GO_0009425 GO:0010410 biolink:BiologicalProcess hemicellulose metabolic process The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present. go.json hemicellulose metabolism http://purl.obolibrary.org/obo/GO_0010410 GO:0009426 biolink:CellularComponent bacterial-type flagellum basal body, distal rod The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. go.json flagellar basal body, distal rod|flagellin-based flagellum basal body, distal rod http://purl.obolibrary.org/obo/GO_0009426 GO:0009427 biolink:CellularComponent bacterial-type flagellum basal body, distal rod, L ring One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane. go.json flagellar basal body, distal rod, L ring|flagellin-based flagellum basal body, distal rod, L ring http://purl.obolibrary.org/obo/GO_0009427 GO:0009428 biolink:CellularComponent bacterial-type flagellum basal body, distal rod, P ring One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer. go.json flagellar basal body, distal rod, P ring|flagellin-based flagellum basal body, distal rod, P ring http://purl.obolibrary.org/obo/GO_0009428 GO:0009429 biolink:CellularComponent bacterial-type flagellum basal body, proximal rod The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor. go.json flagellar basal body, proximal rod|flagellin-based flagellum basal body, proximal rod http://purl.obolibrary.org/obo/GO_0009429 GO:0009400 biolink:MolecularActivity obsolete signal transducer, downstream of receptor, with serine/threonine phosphatase activity OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. go.json receptor signaling protein serine/threonine phosphatase activity|receptor signalling protein serine/threonine phosphatase activity True http://purl.obolibrary.org/obo/GO_0009400 GO:0009401 biolink:BiologicalProcess phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. go.json PTS system http://purl.obolibrary.org/obo/GO_0009401 GO:0009402 biolink:BiologicalProcess obsolete toxin resistance OBSOLETE. (Was not defined before being made obsolete). go.json toxin resistance True http://purl.obolibrary.org/obo/GO_0009402 GO:0009403 biolink:BiologicalProcess toxin biosynthetic process The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. go.json toxin anabolism|toxin biosynthesis|toxin formation|toxin synthesis http://purl.obolibrary.org/obo/GO_0009403 goslim_metagenomics GO:0009404 biolink:BiologicalProcess toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. go.json toxin metabolism http://purl.obolibrary.org/obo/GO_0009404 goslim_pir GO:0009405 biolink:BiologicalProcess obsolete pathogenesis OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism. go.json virulence True http://purl.obolibrary.org/obo/GO_0009405 GO:0009406 biolink:BiologicalProcess obsolete virulence OBSOLETE. (Was not defined before being made obsolete). go.json virulence True http://purl.obolibrary.org/obo/GO_0009406 GO:0009407 biolink:BiologicalProcess toxin catabolic process The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. go.json toxin breakdown|toxin catabolism|toxin degradation http://purl.obolibrary.org/obo/GO_0009407 GO:0009408 biolink:BiologicalProcess response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. go.json response to heat shock http://purl.obolibrary.org/obo/GO_0009408 goslim_yeast GO:0009409 biolink:BiologicalProcess response to cold Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. go.json freezing tolerance http://purl.obolibrary.org/obo/GO_0009409 GO:0034459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034459 GO:0009495 biolink:MolecularActivity obsolete thioredoxin-like 2Fe-2S ferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json thioredoxin-like 2Fe-2S ferredoxin True http://purl.obolibrary.org/obo/GO_0009495 GO:0010484 biolink:MolecularActivity histone H3 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3. go.json H3 histone acetylase activity|H3 histone acetyltransferase activity http://purl.obolibrary.org/obo/GO_0010484 GO:0034451 biolink:CellularComponent centriolar satellite A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. go.json http://purl.obolibrary.org/obo/GO_0034451 GO:0009496 biolink:MolecularActivity plastoquinol--plastocyanin reductase activity Catalysis of the reaction: 2 H+[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H+[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane. EC:7.1.1.6|KEGG_REACTION:R03817|MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN|RHEA:22148 go.json cytochrome b6f|cytochrome b6f complex activity|plastoquinol-plastocyanin reductase activity|plastoquinol/plastocyanin oxidoreductase activity|plastoquinol:oxidized-plastocyanin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0009496 GO:0010485 biolink:MolecularActivity histone H4 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. go.json H4 histone acetylase activity|H4 histone acetyltransferase activity http://purl.obolibrary.org/obo/GO_0010485 GO:0034452 biolink:MolecularActivity dynactin binding Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity. go.json http://purl.obolibrary.org/obo/GO_0034452 GO:0009497 biolink:MolecularActivity obsolete 3Fe-4S/4Fe-4S electron transfer carrier OBSOLETE. (Was not defined before being made obsolete). go.json 3Fe-4S/4Fe-4S electron transfer carrier True http://purl.obolibrary.org/obo/GO_0009497 GO:0010482 biolink:BiologicalProcess regulation of epidermal cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. go.json regulation of hypodermal cell division http://purl.obolibrary.org/obo/GO_0010482 GO:0034453 biolink:BiologicalProcess microtubule anchoring Any process in which a microtubule is maintained in a specific location in a cell. go.json http://purl.obolibrary.org/obo/GO_0034453 GO:0009498 biolink:MolecularActivity obsolete bacterial-type ferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json bacterial-type ferredoxin True http://purl.obolibrary.org/obo/GO_0009498 GO:0010483 biolink:BiologicalProcess pollen tube reception Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells. go.json http://purl.obolibrary.org/obo/GO_0010483 GO:0034454 biolink:BiologicalProcess microtubule anchoring at centrosome Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome. go.json http://purl.obolibrary.org/obo/GO_0034454 GO:0009499 biolink:MolecularActivity obsolete monocluster bacterial-type ferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json monocluster bacterial-type ferredoxin True http://purl.obolibrary.org/obo/GO_0009499 GO:0010488 biolink:MolecularActivity UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP. go.json http://purl.obolibrary.org/obo/GO_0010488 GO:0034455 biolink:CellularComponent t-UTP complex A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. go.json Nan1p-containing subcomplex of 90S preribosome http://purl.obolibrary.org/obo/GO_0034455 GO:0010489 biolink:MolecularActivity UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose. go.json http://purl.obolibrary.org/obo/GO_0010489 GO:0034456 biolink:CellularComponent UTP-C complex A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p. go.json Rrp7p-containing subcomplex of 90S preribosome http://purl.obolibrary.org/obo/GO_0034456 GO:0010486 biolink:MolecularActivity manganese:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in). go.json manganese:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0010486 GO:0034457 biolink:CellularComponent Mpp10 complex A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p. go.json http://purl.obolibrary.org/obo/GO_0034457 GO:0034458 biolink:MolecularActivity 3'-5' RNA helicase activity Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis. Reactome:R-HSA-9836927 go.json 3' to 5' RNA helicase activity|ATP-dependent 3' to 5' RNA helicase activity|ATP-dependent 3'-5' RNA helicase activity http://purl.obolibrary.org/obo/GO_0034458 GO:0010487 biolink:MolecularActivity thermospermine synthase activity Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+. EC:2.5.1.79|MetaCyc:RXN-11190|RHEA:30515 go.json http://purl.obolibrary.org/obo/GO_0010487 GO:0010480 biolink:BiologicalProcess microsporocyte differentiation The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell. go.json pollen mother cell differentiation http://purl.obolibrary.org/obo/GO_0010480 GO:0010481 biolink:BiologicalProcess epidermal cell division Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. go.json hypodermal cell division http://purl.obolibrary.org/obo/GO_0010481 GO:0034450 biolink:MolecularActivity ubiquitin-ubiquitin ligase activity Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. Reactome:R-HSA-937050|Reactome:R-HSA-975122 go.json E4 http://purl.obolibrary.org/obo/GO_0034450 GO:0034448 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034448 GO:0034449 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034449 GO:0034440 biolink:BiologicalProcess lipid oxidation The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. go.json http://purl.obolibrary.org/obo/GO_0034440 GO:0010495 biolink:BiologicalProcess siRNA-mediated long-distance post-transcriptional gene silencing An siRNA-mediated posttranscriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs, and in which the silencing signal originates in one tissue and occurs in a different tissue. go.json long-distance posttranscriptional gene silencing|long-distance propagation of posttranscriptional gene silencing|siRNA-mediated long-distance posttranscriptional gene silencing http://purl.obolibrary.org/obo/GO_0010495 GO:0010496 biolink:BiologicalProcess intercellular transport The movement of substances between cells. go.json single organism intercellular transport|single-organism intercellular transport http://purl.obolibrary.org/obo/GO_0010496 GO:0034441 biolink:BiologicalProcess plasma lipoprotein particle oxidation The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids. go.json plasma lipoprotein oxidation http://purl.obolibrary.org/obo/GO_0034441 GO:0034442 biolink:BiologicalProcess regulation of lipoprotein oxidation Any process that modulates the frequency, rate or extent of lipoprotein oxidation. go.json http://purl.obolibrary.org/obo/GO_0034442 GO:0010493 biolink:BiologicalProcess Lewis a epitope biosynthetic process The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides. go.json LE A biosynthetic process http://purl.obolibrary.org/obo/GO_0010493 GO:0034443 biolink:BiologicalProcess negative regulation of lipoprotein oxidation Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation. go.json inhibition of lipoprotein oxidation http://purl.obolibrary.org/obo/GO_0034443 GO:0010494 biolink:CellularComponent cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Wikipedia:Stress_granule go.json cytoplasmic mRNP granule|stress granule http://purl.obolibrary.org/obo/GO_0010494 GO:0034444 biolink:BiologicalProcess regulation of plasma lipoprotein oxidation Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma. go.json regulation of plasma lipoprotein particle oxidation http://purl.obolibrary.org/obo/GO_0034444 GO:0010499 biolink:BiologicalProcess proteasomal ubiquitin-independent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin. go.json http://purl.obolibrary.org/obo/GO_0010499 GO:0034445 biolink:BiologicalProcess negative regulation of plasma lipoprotein oxidation Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma. go.json inhibition of plasma lipoprotein oxidation|negative regulation of plasma lipoprotein particle oxidation http://purl.obolibrary.org/obo/GO_0034445 GO:0010497 biolink:BiologicalProcess plasmodesmata-mediated intercellular transport The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. go.json plasmodesma-mediated cell-to-cell transport|plasmodesma-mediated intercellular transport|plasmodesmata-mediated cell-to-cell transport|single organism plasmodesmata-mediated intercellular transport|single-organism plasmodesmata-mediated intercellular transport http://purl.obolibrary.org/obo/GO_0010497 GO:0034446 biolink:BiologicalProcess substrate adhesion-dependent cell spreading The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. go.json cell spreading during cell substrate adhesion|substrate adhesion dependent cell spreading http://purl.obolibrary.org/obo/GO_0034446 GO:0034447 biolink:BiologicalProcess very-low-density lipoprotein particle clearance The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json VLDL clearance http://purl.obolibrary.org/obo/GO_0034447 GO:0010498 biolink:BiologicalProcess proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. go.json proteasome-mediated protein catabolic process|proteasome-mediated protein catabolism http://purl.obolibrary.org/obo/GO_0010498 GO:0010491 biolink:MolecularActivity UTP:arabinose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate. go.json http://purl.obolibrary.org/obo/GO_0010491 GO:0010492 biolink:BiologicalProcess maintenance of shoot apical meristem identity The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. go.json http://purl.obolibrary.org/obo/GO_0010492 GO:0010490 biolink:MolecularActivity UDP-4-keto-rhamnose-4-keto-reductase activity Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+. go.json http://purl.obolibrary.org/obo/GO_0010490 GO:0034437 biolink:MolecularActivity obsolete glycoprotein transmembrane transporter activity OBSOLETE. Enables the transfer of a glycoprotein from one side of a membrane to the other. go.json glycoprotein transporter activity True http://purl.obolibrary.org/obo/GO_0034437 GO:0034438 biolink:BiologicalProcess lipoprotein amino acid oxidation The modification of a lipoprotein by oxidation of one or more amino acids in the protein. go.json http://purl.obolibrary.org/obo/GO_0034438 gocheck_do_not_annotate GO:0034439 biolink:BiologicalProcess lipoprotein lipid oxidation The modification of a lipoprotein by oxidation of the lipid group. go.json http://purl.obolibrary.org/obo/GO_0034439 GO:0010468 biolink:BiologicalProcess regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). Wikipedia:Regulation_of_gene_expression go.json gene regulation|regulation of gene product expression|regulation of protein expression http://purl.obolibrary.org/obo/GO_0010468 GO:0010469 biolink:BiologicalProcess regulation of signaling receptor activity Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. go.json regulation of receptor activity|regulation of signalling receptor activity http://purl.obolibrary.org/obo/GO_0010469 gocheck_do_not_annotate GO:0009480 biolink:MolecularActivity obsolete class IIb cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json class IIb cytochrome c True http://purl.obolibrary.org/obo/GO_0009480 GO:0009481 biolink:MolecularActivity obsolete aa3-type cytochrome c oxidase OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. go.json aa3-type cytochrome c oxidase True http://purl.obolibrary.org/obo/GO_0009481 GO:0009482 biolink:MolecularActivity obsolete ba3-type cytochrome c oxidase OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. go.json ba3-type cytochrome c oxidase True http://purl.obolibrary.org/obo/GO_0009482 GO:0009483 biolink:MolecularActivity obsolete caa3-type cytochrome c oxidase OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. go.json caa3-type cytochrome c oxidase True http://purl.obolibrary.org/obo/GO_0009483 GO:0009473 biolink:MolecularActivity obsolete cytochrome c7 (triheme) OBSOLETE. (Was not defined before being made obsolete). go.json cytochrome c7 (triheme) True http://purl.obolibrary.org/obo/GO_0009473 GO:0010462 biolink:BiologicalProcess regulation of light-activated voltage-gated calcium channel activity Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity. go.json http://purl.obolibrary.org/obo/GO_0010462 gocheck_do_not_annotate GO:0009474 biolink:MolecularActivity obsolete nonaheme cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json nonaheme cytochrome c True http://purl.obolibrary.org/obo/GO_0009474 GO:0010463 biolink:BiologicalProcess mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json http://purl.obolibrary.org/obo/GO_0010463 GO:0034430 biolink:CellularComponent monolayer-surrounded lipid storage body outer lipid monolayer The single layer of phopholipids surrounding a lipid storage body. go.json lipid droplet outer lipid monolayer|lipid storage body surface lipid monolayer|oil body outer lipid monolayer|oleosome outer lipid monolayer|spherosome outer lipid monolayer http://purl.obolibrary.org/obo/GO_0034430 GO:0009475 biolink:MolecularActivity obsolete high-molecular-weight cytochrome c (hexadecaheme) OBSOLETE. (Was not defined before being made obsolete). go.json high-molecular-weight cytochrome c (hexadecaheme) True http://purl.obolibrary.org/obo/GO_0009475 GO:0034431 biolink:MolecularActivity bis(5'-adenosyl)-hexaphosphatase activity Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate. RHEA:32047 go.json AP(6)A hydrolase activity|AP-6-A hydrolase activity|AP6A hydrolase activity|diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity http://purl.obolibrary.org/obo/GO_0034431 GO:0010460 biolink:BiologicalProcess positive regulation of heart rate Any process that activates or increases the frequency or rate of heart contraction. go.json http://purl.obolibrary.org/obo/GO_0010460 GO:0034432 biolink:MolecularActivity bis(5'-adenosyl)-pentaphosphatase activity Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. go.json AP(5)A hydrolase activity|AP-5-A hydrolase activity|AP5A hydrolase activity|Ap5a pyrophosphohydrolase activity|diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity http://purl.obolibrary.org/obo/GO_0034432 GO:0009476 biolink:MolecularActivity obsolete class IV cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json class IV cytochrome c True http://purl.obolibrary.org/obo/GO_0009476 GO:0010461 biolink:MolecularActivity light-activated monoatomic ion channel activity Enables the transmembrane transfer of a monoatomic ion by a channel that opens in response to a light stimulus. go.json http://purl.obolibrary.org/obo/GO_0010461 GO:0009477 biolink:MolecularActivity obsolete cytochrome c1 OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c. go.json cytochrome c1 True http://purl.obolibrary.org/obo/GO_0009477 GO:0034433 biolink:BiologicalProcess obsolete steroid esterification OBSOLETE. A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol). go.json True http://purl.obolibrary.org/obo/GO_0034433 GO:0010466 biolink:BiologicalProcess negative regulation of peptidase activity Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. go.json http://purl.obolibrary.org/obo/GO_0010466 gocheck_do_not_annotate GO:0010467 biolink:BiologicalProcess gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. Wikipedia:Gene_expression go.json http://purl.obolibrary.org/obo/GO_0010467 goslim_flybase_ribbon GO:0009478 biolink:MolecularActivity obsolete cytochrome c554 OBSOLETE. (Was not defined before being made obsolete). go.json cytochrome c554 True http://purl.obolibrary.org/obo/GO_0009478 GO:0034434 biolink:BiologicalProcess obsolete sterol esterification OBSOLETE. A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol). go.json True http://purl.obolibrary.org/obo/GO_0034434 GO:0010464 biolink:BiologicalProcess regulation of mesenchymal cell proliferation Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json http://purl.obolibrary.org/obo/GO_0010464 GO:0034435 biolink:BiologicalProcess obsolete cholesterol esterification OBSOLETE. A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. go.json True http://purl.obolibrary.org/obo/GO_0034435 GO:0009479 biolink:MolecularActivity obsolete cytochrome f OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin. go.json cytochrome f True http://purl.obolibrary.org/obo/GO_0009479 GO:0034436 biolink:BiologicalProcess glycoprotein transport The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0034436 GO:0010465 biolink:MolecularActivity nerve growth factor receptor activity Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. go.json NGF receptor activity|beta-nerve growth factor receptor activity http://purl.obolibrary.org/obo/GO_0010465 GO:0034426 biolink:CellularComponent etioplast membrane Either of the lipid bilayers that surround a etioplast and form the etioplast envelope. go.json http://purl.obolibrary.org/obo/GO_0034426 GO:0034427 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. go.json 3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process http://purl.obolibrary.org/obo/GO_0034427 GO:0010479 biolink:BiologicalProcess stele development The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds. go.json http://purl.obolibrary.org/obo/GO_0010479 GO:0034428 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. go.json 5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process http://purl.obolibrary.org/obo/GO_0034428 GO:0009490 biolink:MolecularActivity obsolete mononuclear iron electron carrier OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system. go.json mononuclear iron electron carrier True http://purl.obolibrary.org/obo/GO_0009490 GO:0034429 biolink:BiologicalProcess tectobulbar tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain. go.json http://purl.obolibrary.org/obo/GO_0034429 GO:0009491 biolink:MolecularActivity obsolete redox-active disulfide bond electron carrier OBSOLETE. (Was not defined before being made obsolete). go.json redox-active disulfide bond electron carrier|redox-active disulphide bond electron carrier True http://purl.obolibrary.org/obo/GO_0009491 GO:0009492 biolink:MolecularActivity obsolete 2Fe-2S electron transfer carrier OBSOLETE. (Was not defined before being made obsolete). go.json 2Fe-2S electron transfer carrier True http://purl.obolibrary.org/obo/GO_0009492 GO:0009493 biolink:MolecularActivity obsolete adrenodoxin-type ferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json adrenodoxin-type ferredoxin True http://purl.obolibrary.org/obo/GO_0009493 GO:0009494 biolink:MolecularActivity obsolete chloroplast-type ferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json chloroplast-type ferredoxin True http://purl.obolibrary.org/obo/GO_0009494 GO:0010473 biolink:MolecularActivity GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol. go.json http://purl.obolibrary.org/obo/GO_0010473 GO:0009484 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009484 GO:0009485 biolink:MolecularActivity obsolete cbb3-type cytochrome c oxidase OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. go.json cbb3-type cytochrome c oxidase True http://purl.obolibrary.org/obo/GO_0009485 GO:0010474 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010474 GO:0010471 biolink:MolecularActivity GDP-galactose:mannose-1-phosphate guanylyltransferase activity Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + beta-L-galactose-1-phosphate. EC:2.7.7.69|MetaCyc:RXN4FS-12|RHEA:65708 go.json GDP-L-galactose phosphorylase activity|GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0010471 GO:0009486 biolink:MolecularActivity cytochrome bo3 ubiquinol oxidase activity Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]. EC:7.1.1.3|MetaCyc:RXN0-5268|RHEA:30251|TC:3.D.4.5.1 go.json cytochrome bo oxidase|cytochrome bo(3) oxidase|cytochrome o ubiquinol oxidase activity http://purl.obolibrary.org/obo/GO_0009486 GO:0034420 biolink:BiologicalProcess co-translational protein acetylation The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome. go.json co-translational protein amino acid acetylation|cotranslational protein amino acid acetylation http://purl.obolibrary.org/obo/GO_0034420 gocheck_do_not_annotate GO:0034421 biolink:BiologicalProcess post-translational protein acetylation The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome. go.json post-translational protein amino acid acetylation|posttranslational protein amino acid acetylation http://purl.obolibrary.org/obo/GO_0034421 gocheck_do_not_annotate GO:0009487 biolink:MolecularActivity obsolete glutaredoxin OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase. go.json glutaredoxin True http://purl.obolibrary.org/obo/GO_0009487 GO:0010472 biolink:MolecularActivity GDP-galactose:glucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-glucose 1-phosphate = beta-L-galactose-1-phosphate + GDP-alpha-D-glucose. EC:2.7.7.69|MetaCyc:RXN4FS-13|RHEA:65712 go.json GDP-L-galactose phosphorylase activity|GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0010472 GO:0009488 biolink:MolecularActivity obsolete amicyanin OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c. go.json amicyanin True http://purl.obolibrary.org/obo/GO_0009488 GO:0010477 biolink:BiologicalProcess response to sulfur dioxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0010477 GO:0034422 biolink:CellularComponent aleurone grain lumen The volume enclosed by the membrane of an aleurone grain. go.json http://purl.obolibrary.org/obo/GO_0034422 GO:0009489 biolink:MolecularActivity obsolete rubredoxin OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues. go.json rubredoxin True http://purl.obolibrary.org/obo/GO_0009489 GO:0010478 biolink:BiologicalProcess chlororespiration A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool. go.json http://purl.obolibrary.org/obo/GO_0010478 GO:0034423 biolink:CellularComponent autophagosome lumen The volume enclosed within the autophagosome double-membrane. go.json autophagic vacuole lumen http://purl.obolibrary.org/obo/GO_0034423 GO:0034424 biolink:CellularComponent Vps55/Vps68 complex A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins. go.json http://purl.obolibrary.org/obo/GO_0034424 GO:0010475 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010475 GO:0010476 biolink:BiologicalProcess gibberellin mediated signaling pathway The series of molecular signals generated as a consequence of gibberellin stimulus. go.json gibberellin-mediated signalling http://purl.obolibrary.org/obo/GO_0010476 GO:0034425 biolink:CellularComponent etioplast envelope The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0034425 GO:0010470 biolink:BiologicalProcess regulation of gastrulation Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. go.json http://purl.obolibrary.org/obo/GO_0010470 GO:0034415 biolink:BiologicalProcess obsolete tRNA 3'-trailer cleavage, exonucleolytic OBSOLETE. Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. go.json exonucleolytic tRNA 3'-end cleavage|exonucleolytic tRNA 3'-trailer cleavage|tRNA 3'-end cleavage, exonucleolytic True http://purl.obolibrary.org/obo/GO_0034415 GO:0010448 biolink:BiologicalProcess vegetative meristem growth The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia. go.json http://purl.obolibrary.org/obo/GO_0010448 GO:0034416 biolink:MolecularActivity obsolete bisphosphoglycerate phosphatase activity OBSOLETE. Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate. go.json 2,3-bisphosphoglycerate phosphatase activity|2,3-diphosphoglycerate phosphatase activity|2,3-diphosphoglyceric acid phosphatase activity|diphosphoglycerate phosphatase activity|glycerate-2,3-diphosphate phosphatase activity True http://purl.obolibrary.org/obo/GO_0034416 GO:0010449 biolink:BiologicalProcess root meristem growth The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root. go.json http://purl.obolibrary.org/obo/GO_0010449 GO:0034417 biolink:MolecularActivity bisphosphoglycerate 3-phosphatase activity Catalysis of the reaction: (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate. EC:3.1.3.80|KEGG_REACTION:R09532|MetaCyc:RXN-11102|RHEA:27381 go.json 2,3-bisphospho-D-glycerate 3-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0034417 GO:0010446 biolink:BiologicalProcess response to alkaline pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. go.json response to alkalinity|response to basic pH http://purl.obolibrary.org/obo/GO_0010446 GO:0034418 biolink:BiologicalProcess urate biosynthetic process The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine. go.json urate anabolism|urate biosynthesis|urate formation|urate synthesis|uric acid biosynthetic process http://purl.obolibrary.org/obo/GO_0034418 GO:0010447 biolink:BiologicalProcess response to acidic pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. go.json response to acidity http://purl.obolibrary.org/obo/GO_0010447 GO:0034419 biolink:MolecularActivity obsolete L-2-hydroxyglutarate oxidase activity OBSOLETE. Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + hydrogen peroxide. go.json True http://purl.obolibrary.org/obo/GO_0034419 GO:0009460 biolink:MolecularActivity obsolete cytochrome b OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b). go.json cytochrome b True http://purl.obolibrary.org/obo/GO_0009460 GO:0009461 biolink:MolecularActivity obsolete cytochrome c OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues. go.json True http://purl.obolibrary.org/obo/GO_0009461 GO:0010440 biolink:BiologicalProcess stomatal lineage progression The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex. go.json http://purl.obolibrary.org/obo/GO_0010440 GO:0009451 biolink:BiologicalProcess RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. Wikipedia:RNA_editing go.json RNA editing http://purl.obolibrary.org/obo/GO_0009451 goslim_yeast GO:0010441 biolink:BiologicalProcess guard cell development The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0010441 GO:0009452 biolink:BiologicalProcess 7-methylguanosine RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. go.json RNA capping|m(7)G RNA capping http://purl.obolibrary.org/obo/GO_0009452 GO:0009453 biolink:BiologicalProcess energy taxis The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. go.json energytaxis|taxis in response to energy source http://purl.obolibrary.org/obo/GO_0009453 GO:0009454 biolink:BiologicalProcess aerotaxis The directed movement of a motile cell or organism in response to environmental oxygen. go.json taxis in response to atmospheric oxygen http://purl.obolibrary.org/obo/GO_0009454 GO:0034410 biolink:BiologicalProcess cell wall beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells. go.json cell wall beta-glucan anabolism|cell wall beta-glucan biosynthesis|cell wall beta-glucan formation|cell wall beta-glucan synthesis http://purl.obolibrary.org/obo/GO_0034410 GO:0034411 biolink:BiologicalProcess cell wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. go.json cell wall 1,3-beta-D-glucan biosynthetic process|cell wall 1,3-beta-glucan anabolism|cell wall 1,3-beta-glucan biosynthesis|cell wall 1,3-beta-glucan biosynthetic process|cell wall 1,3-beta-glucan formation|cell wall 1,3-beta-glucan synthesis|cell wall beta-1,3-glucan anabolism|cell wall beta-1,3-glucan biosynthesis|cell wall beta-1,3-glucan biosynthetic process|cell wall beta-1,3-glucan formation|cell wall beta-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0034411 GO:0009455 biolink:BiologicalProcess redox taxis The directed movement of a motile cell or organism in response to redox potential. go.json redoxtaxis|taxis in response to redox potential|taxis in response to redox stimulus http://purl.obolibrary.org/obo/GO_0009455 GO:0010444 biolink:BiologicalProcess guard mother cell differentiation The process in which a meristemoid acquires the specialized features of a guard mother cell. go.json http://purl.obolibrary.org/obo/GO_0010444 GO:0034412 biolink:BiologicalProcess ascospore wall beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. go.json ascospore wall beta-glucan anabolism|ascospore wall beta-glucan biosynthesis|ascospore wall beta-glucan formation|ascospore wall beta-glucan synthesis http://purl.obolibrary.org/obo/GO_0034412 GO:0010445 biolink:CellularComponent nuclear dicing body A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes. go.json D body http://purl.obolibrary.org/obo/GO_0010445 GO:0009456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009456 GO:0009457 biolink:MolecularActivity obsolete flavodoxin OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide. go.json flavodoxin True http://purl.obolibrary.org/obo/GO_0009457 GO:0034413 biolink:BiologicalProcess ascospore wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores. go.json ascospore wall 1,3-beta-D-glucan biosynthetic process|ascospore wall 1,3-beta-glucan anabolism|ascospore wall 1,3-beta-glucan biosynthesis|ascospore wall 1,3-beta-glucan biosynthetic process|ascospore wall 1,3-beta-glucan formation|ascospore wall 1,3-beta-glucan synthesis|ascospore wall beta-1,3-glucan anabolism|ascospore wall beta-1,3-glucan biosynthesis|ascospore wall beta-1,3-glucan biosynthetic process|ascospore wall beta-1,3-glucan formation|ascospore wall beta-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0034413 GO:0010442 biolink:BiologicalProcess guard cell morphogenesis Generation and organization of the polarized cell that is capable of turgor driven movement. go.json guard cell morphogenesis during differentiation http://purl.obolibrary.org/obo/GO_0010442 GO:0009458 biolink:MolecularActivity obsolete cytochrome OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom. go.json cytochrome True http://purl.obolibrary.org/obo/GO_0009458 GO:0010443 biolink:BiologicalProcess meristemoid mother cell division The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC. go.json meristemoid division http://purl.obolibrary.org/obo/GO_0010443 GO:0034414 biolink:BiologicalProcess obsolete tRNA 3'-trailer cleavage, endonucleolytic OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. go.json endonucleolytic tRNA 3'-end cleavage|endonucleolytic tRNA 3'-trailer cleavage|tRNA 3'-end cleavage, endonucleolytic True http://purl.obolibrary.org/obo/GO_0034414 GO:0009459 biolink:MolecularActivity obsolete cytochrome a OBSOLETE. A cytochrome containing heme a. go.json cytochrome a True http://purl.obolibrary.org/obo/GO_0009459 GO:0034404 biolink:BiologicalProcess nucleobase-containing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. go.json nucleobase, nucleoside and nucleotide anabolism|nucleobase, nucleoside and nucleotide biosynthesis|nucleobase, nucleoside and nucleotide formation|nucleobase, nucleoside and nucleotide synthesis http://purl.obolibrary.org/obo/GO_0034404 GO:0010459 biolink:BiologicalProcess negative regulation of heart rate Any process that stops, prevents or reduces the frequency or rate of heart contraction. go.json http://purl.obolibrary.org/obo/GO_0010459 GO:0034405 biolink:BiologicalProcess response to fluid shear stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. go.json http://purl.obolibrary.org/obo/GO_0034405 GO:0010457 biolink:BiologicalProcess centriole-centriole cohesion The cell cycle process in which the two centrioles within a centrosome remain tightly paired. go.json http://purl.obolibrary.org/obo/GO_0010457 GO:0034406 biolink:BiologicalProcess cell wall beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells. go.json cell wall beta-glucan metabolism http://purl.obolibrary.org/obo/GO_0034406 GO:0034407 biolink:BiologicalProcess cell wall (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. go.json cell wall 1,3-beta-D-glucan metabolic process|cell wall 1,3-beta-glucan metabolic process|cell wall 1,3-beta-glucan metabolism|cell wall beta-1,3 glucan metabolic process|cell wall beta-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0034407 GO:0010458 biolink:BiologicalProcess exit from mitosis The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. go.json exit from mitotic division|mitotic exit http://purl.obolibrary.org/obo/GO_0010458 GO:0034408 biolink:BiologicalProcess ascospore wall beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. go.json ascospore wall beta-glucan metabolism http://purl.obolibrary.org/obo/GO_0034408 GO:0034409 biolink:BiologicalProcess ascospore wall (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores. go.json ascospore wall 1,3-beta-D-glucan metabolic process|ascospore wall 1,3-beta-glucan metabolic process|ascospore wall 1,3-beta-glucan metabolism|ascospore wall beta-1,3 glucan metabolic process|ascospore wall beta-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0034409 GO:0009470 biolink:MolecularActivity obsolete class IIa cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json class IIa cytochrome c True http://purl.obolibrary.org/obo/GO_0009470 GO:0009471 biolink:MolecularActivity obsolete class III cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json class III cytochrome c True http://purl.obolibrary.org/obo/GO_0009471 GO:0009472 biolink:MolecularActivity obsolete cytochrome c3 (tetraheme) OBSOLETE. (Was not defined before being made obsolete). go.json cytochrome c3 (tetraheme) True http://purl.obolibrary.org/obo/GO_0009472 GO:0009462 biolink:MolecularActivity obsolete cytochrome d OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes. go.json cytochrome d True http://purl.obolibrary.org/obo/GO_0009462 GO:0010451 biolink:BiologicalProcess floral meristem growth The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower. go.json http://purl.obolibrary.org/obo/GO_0010451 GO:0009463 biolink:MolecularActivity obsolete cytochrome b/b6 OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis. go.json cytochrome b/b6 True http://purl.obolibrary.org/obo/GO_0009463 GO:0010452 biolink:BiologicalProcess histone H3-K36 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone. go.json histone H3 K36 methylation|histone H3K36me|histone lysine H3 K36 methylation http://purl.obolibrary.org/obo/GO_0010452 gocheck_do_not_annotate GO:0009464 biolink:MolecularActivity obsolete cytochrome b5 OBSOLETE. (Was not defined before being made obsolete). go.json cytochrome b5 True http://purl.obolibrary.org/obo/GO_0009464 GO:0009465 biolink:MolecularActivity obsolete soluble cytochrome b562 OBSOLETE. (Was not defined before being made obsolete). go.json soluble cytochrome b562 True http://purl.obolibrary.org/obo/GO_0009465 GO:0010450 biolink:BiologicalProcess inflorescence meristem growth The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers. go.json http://purl.obolibrary.org/obo/GO_0010450 GO:0034400 biolink:CellularComponent gerontoplast A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence. go.json http://purl.obolibrary.org/obo/GO_0034400 GO:0010455 biolink:BiologicalProcess positive regulation of cell fate commitment Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. go.json http://purl.obolibrary.org/obo/GO_0010455 GO:0009466 biolink:MolecularActivity obsolete class I cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json class I cytochrome c True http://purl.obolibrary.org/obo/GO_0009466 GO:0034401 biolink:BiologicalProcess obsolete chromatin organization involved in regulation of transcription OBSOLETE. Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription. go.json activation of global transcription from RNA polymerase II promoter by histone modification|activation of transcription from RNA polymerase II promoter by histone modification|establishment or maintenance of chromatin architecture during transcription|positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification|positive regulation of global transcription from Pol II promoter by histone modification|positive regulation of transcription from Pol II promoter by histone modification|positive regulation of transcription from RNA polymerase II promoter by histone modification|positive regulation of transcription from RNA polymerase II promoter, global by histone modification|regulation of gene-specific transcription from RNA polymerase II promoter by histone modification|regulation of global transcription from Pol II promoter by histone modification|regulation of transcription by chromatin organisation|regulation of transcription by chromatin organization|regulation of transcription from Pol II promoter by histone modification|regulation of transcription from RNA polymerase II promoter by histone modification|regulation of transcription from RNA polymerase II promoter, global by histone modification|stimulation of global transcription from RNA polymerase II promoter by histone modification|stimulation of transcription from RNA polymerase II promoter by histone modification|up regulation of global transcription from RNA polymerase II promoter by histone modification|up regulation of transcription from RNA polymerase II promoter by histone modification|up-regulation of global transcription from RNA polymerase II promoter by histone modification|up-regulation of transcription from RNA polymerase II promoter by histone modification|upregulation of global transcription from RNA polymerase II promoter by histone modification|upregulation of transcription from RNA polymerase II promoter by histone modification True http://purl.obolibrary.org/obo/GO_0034401 GO:0009467 biolink:MolecularActivity obsolete monoheme class I cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json monoheme class I cytochrome c True http://purl.obolibrary.org/obo/GO_0009467 GO:0010456 biolink:BiologicalProcess cell proliferation in dorsal spinal cord The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population. go.json http://purl.obolibrary.org/obo/GO_0010456 GO:0010453 biolink:BiologicalProcess regulation of cell fate commitment Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. go.json http://purl.obolibrary.org/obo/GO_0010453 GO:0009468 biolink:MolecularActivity obsolete diheme class I cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json diheme class I cytochrome c True http://purl.obolibrary.org/obo/GO_0009468 GO:0034402 biolink:BiologicalProcess recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript. go.json http://purl.obolibrary.org/obo/GO_0034402 GO:0010454 biolink:BiologicalProcess negative regulation of cell fate commitment Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. go.json http://purl.obolibrary.org/obo/GO_0010454 GO:0034403 biolink:BiologicalProcess alignment of 3' and 5' splice sites of mRNA Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur. go.json alignment of 3' and 5' splice sites of nuclear mRNA http://purl.obolibrary.org/obo/GO_0034403 GO:0009469 biolink:MolecularActivity obsolete class II cytochrome c OBSOLETE. (Was not defined before being made obsolete). go.json class II cytochrome c True http://purl.obolibrary.org/obo/GO_0009469 GO:0010426 biolink:BiologicalProcess DNA methylation on cytosine within a CHH sequence The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide. go.json DNA methylation on cytosine within a CNN sequence|cytosine methylation within a CHH sequence|cytosine methylation within a CNN sequence http://purl.obolibrary.org/obo/GO_0010426 GO:0010427 biolink:MolecularActivity abscisic acid binding Binding to abscisic acid, a plant hormone that regulates aspects of plant growth. go.json ABA binding|abscisate binding http://purl.obolibrary.org/obo/GO_0010427 GO:0010424 biolink:BiologicalProcess DNA methylation on cytosine within a CG sequence The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule. go.json cytosine methylation within a CG sequence http://purl.obolibrary.org/obo/GO_0010424 GO:0010425 biolink:BiologicalProcess DNA methylation on cytosine within a CNG sequence The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide. go.json cytosine methylation within a CNG sequence http://purl.obolibrary.org/obo/GO_0010425 GO:0010428 biolink:MolecularActivity methyl-CpNpG binding Binding to a methylated cytosine/unspecified/guanine trinucleotide. go.json http://purl.obolibrary.org/obo/GO_0010428 GO:0010429 biolink:MolecularActivity methyl-CpNpN binding Binding to a methylated cytosine/unspecified/unspecified trinucleotide. go.json http://purl.obolibrary.org/obo/GO_0010429 GO:0009430 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009430 GO:0009431 biolink:CellularComponent bacterial-type flagellum basal body, MS ring One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. go.json flagellar basal body, MS ring|flagellar basal body, mounting plate|flagellin-based flagellum basal body, MS ring http://purl.obolibrary.org/obo/GO_0009431 GO:0009432 biolink:BiologicalProcess SOS response An error-prone process for repairing damaged microbial DNA. Wikipedia:SOS_response go.json http://purl.obolibrary.org/obo/GO_0009432 GO:0009433 biolink:CellularComponent bacterial-type flagellum basal body, C ring Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. go.json flagellar basal body, C ring|flagellin-based flagellum basal body, C ring http://purl.obolibrary.org/obo/GO_0009433 GO:0010422 biolink:BiologicalProcess regulation of brassinosteroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids. go.json http://purl.obolibrary.org/obo/GO_0010422 GO:0010423 biolink:BiologicalProcess negative regulation of brassinosteroid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids. go.json http://purl.obolibrary.org/obo/GO_0010423 GO:0009434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009434 GO:0010420 biolink:MolecularActivity 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+. EC:2.1.1.114|MetaCyc:RXN-9281|RHEA:44452 go.json polyprenyldihydroxybenzoate methyltransferase activity http://purl.obolibrary.org/obo/GO_0010420 GO:0009435 biolink:BiologicalProcess NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. go.json NAD (oxidized) biosynthesis|NAD (oxidized) biosynthetic process|NAD (reduced) biosynthesis|NAD (reduced) biosynthetic process|NAD anabolism|NAD biosynthesis|NAD formation|NAD synthesis|NADH biosynthesis|NADH biosynthetic process|nicotinamide adenine dinucleotide biosynthesis|nicotinamide adenine dinucleotide biosynthetic process|oxidized NAD biosynthesis|oxidized NAD biosynthetic process|oxidized nicotinamide adenine dinucleotide biosynthesis|oxidized nicotinamide adenine dinucleotide biosynthetic process|reduced NAD biosynthesis|reduced NAD biosynthetic process|reduced nicotinamide adenine dinucleotide biosynthesis|reduced nicotinamide adenine dinucleotide biosynthetic process http://purl.obolibrary.org/obo/GO_0009435 GO:0009436 biolink:BiologicalProcess glyoxylate catabolic process The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH. MetaCyc:GLYOXDEG-PWY go.json glyoxylate breakdown|glyoxylate catabolism|glyoxylate degradation http://purl.obolibrary.org/obo/GO_0009436 GO:0010421 biolink:BiologicalProcess hydrogen peroxide-mediated programmed cell death Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes. go.json programmed cell death in response to hydrogen peroxide http://purl.obolibrary.org/obo/GO_0010421 GO:0009437 biolink:BiologicalProcess carnitine metabolic process The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. go.json carnitine metabolism|vitamin Bt metabolic process|vitamin Bt metabolism http://purl.obolibrary.org/obo/GO_0009437 GO:0009438 biolink:BiologicalProcess methylglyoxal metabolic process The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. MetaCyc:METHGLYUT-PWY go.json methylglyoxal bypass|methylglyoxal metabolism|methylglyoxal pathway http://purl.obolibrary.org/obo/GO_0009438 GO:0009439 biolink:BiologicalProcess cyanate metabolic process The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. MetaCyc:CYANCAT-PWY go.json cyanate metabolism http://purl.obolibrary.org/obo/GO_0009439 GO:0010437 biolink:MolecularActivity 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond. go.json http://purl.obolibrary.org/obo/GO_0010437 GO:0010438 biolink:BiologicalProcess cellular response to sulfur starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur. go.json http://purl.obolibrary.org/obo/GO_0010438 GO:0010435 biolink:MolecularActivity 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0. EC:6.2.1.-|MetaCyc:RXN-10695 go.json 3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity|3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity|OPC-8:0 CoA ligase activity http://purl.obolibrary.org/obo/GO_0010435 GO:0010436 biolink:MolecularActivity carotenoid dioxygenase activity Catalysis of the oxidative cleavage of carotenoids. go.json carotenoid-cleaving dioxygenase http://purl.obolibrary.org/obo/GO_0010436 GO:0010439 biolink:BiologicalProcess regulation of glucosinolate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. go.json http://purl.obolibrary.org/obo/GO_0010439 GO:0009450 biolink:BiologicalProcess gamma-aminobutyric acid catabolic process The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. MetaCyc:4AMINOBUTMETAB-PWY go.json 4-aminobutanoate catabolic process|4-aminobutanoate catabolism|4-aminobutyrate catabolic process|4-aminobutyrate catabolism|GABA catabolic process|GABA catabolism|gamma-aminobutyric acid breakdown|gamma-aminobutyric acid catabolism|gamma-aminobutyric acid degradation http://purl.obolibrary.org/obo/GO_0009450 GO:0009440 biolink:BiologicalProcess cyanate catabolic process The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid. go.json cyanate breakdown|cyanate catabolism|cyanate degradation http://purl.obolibrary.org/obo/GO_0009440 GO:0010430 biolink:BiologicalProcess fatty acid omega-oxidation A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. MetaCyc:PWY-2724 go.json http://purl.obolibrary.org/obo/GO_0010430 GO:0009441 biolink:BiologicalProcess glycolate metabolic process The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid). MetaCyc:GLYCOLATEMET-PWY go.json glycolate metabolism http://purl.obolibrary.org/obo/GO_0009441 GO:0009442 biolink:BiologicalProcess allantoin assimilation pathway The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP. MetaCyc:PWY0-41 go.json allantoin catabolic process via ureidoglycolate|allantoin catabolism via ureidoglycolate|allantoin degradation pathway http://purl.obolibrary.org/obo/GO_0009442 GO:0009443 biolink:BiologicalProcess pyridoxal 5'-phosphate salvage Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. MetaCyc:PLPSAL-PWY go.json pyridoxal 5' phosphate salvage http://purl.obolibrary.org/obo/GO_0009443 GO:0009444 biolink:BiologicalProcess pyruvate oxidation The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate. MetaCyc:PYRUVOX-PWY|Wikipedia:Pyruvate_decarboxylation go.json http://purl.obolibrary.org/obo/GO_0009444 GO:0010433 biolink:BiologicalProcess bract morphogenesis The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. go.json http://purl.obolibrary.org/obo/GO_0010433 GO:0009445 biolink:BiologicalProcess putrescine metabolic process The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. go.json putrescine metabolism http://purl.obolibrary.org/obo/GO_0009445 GO:0010434 biolink:BiologicalProcess bract formation The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. go.json http://purl.obolibrary.org/obo/GO_0010434 GO:0010431 biolink:BiologicalProcess seed maturation A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination. go.json http://purl.obolibrary.org/obo/GO_0010431 GO:0009446 biolink:BiologicalProcess putrescine biosynthetic process The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. go.json putrescine anabolism|putrescine biosynthesis|putrescine formation|putrescine synthesis http://purl.obolibrary.org/obo/GO_0009446 GO:0010432 biolink:BiologicalProcess bract development The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. go.json http://purl.obolibrary.org/obo/GO_0010432 GO:0009447 biolink:BiologicalProcess putrescine catabolic process The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. go.json putrescine breakdown|putrescine catabolism|putrescine degradation http://purl.obolibrary.org/obo/GO_0009447 GO:0009448 biolink:BiologicalProcess gamma-aminobutyric acid metabolic process The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. go.json 4-aminobutanoate metabolic process|4-aminobutanoate metabolism|4-aminobutyrate metabolic process|4-aminobutyrate metabolism|GABA metabolic process|GABA metabolism|gamma-aminobutyric acid metabolism http://purl.obolibrary.org/obo/GO_0009448 GO:0009449 biolink:BiologicalProcess gamma-aminobutyric acid biosynthetic process The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. go.json 4-aminobutanoate biosynthesis|4-aminobutanoate biosynthetic process|4-aminobutyrate biosynthesis|4-aminobutyrate biosynthetic process|GABA biosynthesis|GABA biosynthetic process|gamma-aminobutyric acid anabolism|gamma-aminobutyric acid biosynthesis|gamma-aminobutyric acid formation|gamma-aminobutyric acid synthesis http://purl.obolibrary.org/obo/GO_0009449 GO:0034396 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter in response to iron Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. go.json down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of transcription from Pol II promoter in response to iron http://purl.obolibrary.org/obo/GO_0034396 GO:0034397 biolink:BiologicalProcess telomere localization Any process in which a telomere is transported to, and/or maintained in, a specific location. go.json telomere localisation http://purl.obolibrary.org/obo/GO_0034397 GO:0034398 biolink:BiologicalProcess telomere tethering at nuclear periphery The process in which a telomere is maintained in a specific location at the nuclear periphery. go.json http://purl.obolibrary.org/obo/GO_0034398 GO:0034399 biolink:CellularComponent nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane. go.json http://purl.obolibrary.org/obo/GO_0034399 GO:0034390 biolink:BiologicalProcess smooth muscle cell apoptotic process Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. go.json SMC apoptosis|apoptosis of smooth muscle cells|programmed cell death of smooth muscle cells by apoptosis|programmed cell death, smooth muscle cells|smooth muscle cell apoptosis|smooth muscle cell programmed cell death by apoptosis http://purl.obolibrary.org/obo/GO_0034390 GO:0034391 biolink:BiologicalProcess regulation of smooth muscle cell apoptotic process Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. go.json regulation of SMC apoptosis|regulation of smooth muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0034391 GO:0034392 biolink:BiologicalProcess negative regulation of smooth muscle cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. go.json down regulation of smooth muscle cell apoptosis|down-regulation of smooth muscle cell apoptosis|downregulation of smooth muscle cell apoptosis|inhibition of smooth muscle cell apoptosis|negative regulation of SMC apoptosis|negative regulation of smooth muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0034392 GO:0034393 biolink:BiologicalProcess positive regulation of smooth muscle cell apoptotic process Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. go.json activation of smooth muscle cell apoptosis|positive regulation of SMC apoptosis|positive regulation of smooth muscle cell apoptosis|stimulation of smooth muscle cell apoptosis|up regulation of smooth muscle cell apoptosis|up-regulation of smooth muscle cell apoptosis|upregulation of smooth muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0034393 GO:0034394 biolink:BiologicalProcess protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. go.json protein localisation at cell surface|protein localization at cell surface http://purl.obolibrary.org/obo/GO_0034394 GO:0034395 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter in response to iron Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus. go.json regulation of specific transcription from RNA polymerase II promoter in response to iron http://purl.obolibrary.org/obo/GO_0034395 GO:0034385 biolink:CellularComponent triglyceride-rich plasma lipoprotein particle A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood. go.json triacylglycerol-rich lipoprotein particle|triglyceride-rich lipoprotein particle http://purl.obolibrary.org/obo/GO_0034385 GO:0034386 biolink:MolecularActivity 4-aminobutyrate:2-oxoglutarate transaminase activity Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. EC:2.6.1.19|MetaCyc:GABATRANSAM-RXN go.json 4-aminobutanoate:2-oxoglutarate aminotransferase activity|4-aminobutyrate-2-ketoglutarate aminotransferase activity|4-aminobutyrate-2-oxoglutarate aminotransferase activity|4-aminobutyrate-2-oxoglutarate transaminase activity|4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity|GABA-2-oxoglutarate aminotransferase activity|GABA-2-oxoglutarate transaminase activity|GABA-alpha-ketoglutarate aminotransferase activity|GABA-alpha-ketoglutarate transaminase activity|GABA-alpha-ketoglutaric acid transaminase activity|GABA-alpha-oxoglutarate aminotransferase activity|GABA-oxoglutarate aminotransferase activity|GABA-oxoglutarate transaminase activity|gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity|gamma-aminobutyrate-alpha-ketoglutarate transaminase activity|gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity|gamma-aminobutyric acid-2-oxoglutarate transaminase activity|gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity|gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity http://purl.obolibrary.org/obo/GO_0034386 GO:0034387 biolink:MolecularActivity 4-aminobutyrate:pyruvate transaminase activity Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine. EC:2.6.1.96|MetaCyc:RXN-6902|RHEA:32263 go.json gamma-aminobutyric acid pyruvate transaminase activity http://purl.obolibrary.org/obo/GO_0034387 GO:0034388 biolink:CellularComponent Pwp2p-containing subcomplex of 90S preribosome A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. go.json 25-30 S subcomplex of 90S preribosome|UTP-B complex http://purl.obolibrary.org/obo/GO_0034388 GO:0034389 biolink:BiologicalProcess lipid droplet organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. go.json adiposome organization|lipid body organization|lipid particle organisation|lipid particle organization|lipid particle organization and biogenesis http://purl.obolibrary.org/obo/GO_0034389 GO:0034380 biolink:BiologicalProcess high-density lipoprotein particle assembly The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. go.json HDL assembly http://purl.obolibrary.org/obo/GO_0034380 GO:0034381 biolink:BiologicalProcess plasma lipoprotein particle clearance The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json lipoprotein particle clearance http://purl.obolibrary.org/obo/GO_0034381 GO:0034382 biolink:BiologicalProcess chylomicron remnant clearance The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0034382 GO:0034383 biolink:BiologicalProcess low-density lipoprotein particle clearance The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json LDL clearance http://purl.obolibrary.org/obo/GO_0034383 GO:0034384 biolink:BiologicalProcess high-density lipoprotein particle clearance The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json HDL clearance http://purl.obolibrary.org/obo/GO_0034384 GO:0034374 biolink:BiologicalProcess low-density lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. go.json LDL remodeling|LDL remodelling|low-density lipoprotein particle remodelling|small dense LDL formation|small dense low-density lipoprotein particle formation http://purl.obolibrary.org/obo/GO_0034374 GO:0034375 biolink:BiologicalProcess high-density lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. go.json HDL remodeling|HDL remodelling|high-density lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0034375 GO:0034376 biolink:BiologicalProcess conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle. go.json conversion of discoidal HDL to spherical HDL|discoidal HDL remodeling|discoidal high-density lipoprotein remodeling http://purl.obolibrary.org/obo/GO_0034376 GO:0034377 biolink:BiologicalProcess plasma lipoprotein particle assembly The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle. go.json http://purl.obolibrary.org/obo/GO_0034377 GO:0034378 biolink:BiologicalProcess chylomicron assembly The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron. go.json http://purl.obolibrary.org/obo/GO_0034378 GO:0034379 biolink:BiologicalProcess very-low-density lipoprotein particle assembly The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle. go.json VLDL assembly http://purl.obolibrary.org/obo/GO_0034379 GO:0034370 biolink:BiologicalProcess triglyceride-rich lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle. go.json triacylglycerol-rich lipoprotein particle remodeling|triacylglycerol-rich lipoprotein particle remodelling|triglyceride-rich lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0034370 GO:0034371 biolink:BiologicalProcess chylomicron remodeling The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. go.json chylomicron remnant formation|chylomicron remodelling http://purl.obolibrary.org/obo/GO_0034371 GO:0034372 biolink:BiologicalProcess very-low-density lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. go.json VDL formation|VDL remodeling|VDL remodelling|very-low-density lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0034372 GO:0034373 biolink:BiologicalProcess intermediate-density lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle. go.json IDL remodeling|IDL remodelling|intermediate-density lipoprotein particle formation|intermediate-density lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0034373 GO:0034363 biolink:CellularComponent intermediate-density lipoprotein particle A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL). go.json IDL complex|IDL particle|intermediate-density lipoprotein complex http://purl.obolibrary.org/obo/GO_0034363 GO:0034364 biolink:CellularComponent high-density lipoprotein particle A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. go.json HDL complex|HDL particle|HDL2|HDL3|high-density lipoprotein class complex http://purl.obolibrary.org/obo/GO_0034364 GO:0034365 biolink:CellularComponent discoidal high-density lipoprotein particle A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase). go.json discoidal HDL|nascent HDL|nascent high-density lipoprotein particle http://purl.obolibrary.org/obo/GO_0034365 GO:0034366 biolink:CellularComponent spherical high-density lipoprotein particle A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). go.json mature HDL|mature high-density lipoprotein particle|spherical HDL http://purl.obolibrary.org/obo/GO_0034366 GO:0034367 biolink:BiologicalProcess protein-containing complex remodeling The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. go.json macromolecular complex remodeling|macromolecular complex remodelling|protein-containing complex remodelling http://purl.obolibrary.org/obo/GO_0034367 GO:0034368 biolink:BiologicalProcess protein-lipid complex remodeling The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. go.json protein-lipid complex remodelling http://purl.obolibrary.org/obo/GO_0034368 GO:0034369 biolink:BiologicalProcess plasma lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). go.json plasma lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0034369 GO:0034360 biolink:CellularComponent chylomicron remnant A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver. go.json http://purl.obolibrary.org/obo/GO_0034360 GO:0034361 biolink:CellularComponent very-low-density lipoprotein particle A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. go.json VLDL complex|VLDL particle|very-low-density lipoprotein complex http://purl.obolibrary.org/obo/GO_0034361 GO:0034362 biolink:CellularComponent low-density lipoprotein particle A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. go.json LDL complex|LDL particle|low-density lipoprotein complex http://purl.obolibrary.org/obo/GO_0034362 GO:0009396 biolink:BiologicalProcess folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. go.json folate and derivative biosynthesis|folate and derivative biosynthetic process|folate-containing compound biosynthesis|folate-containing compound biosynthetic process|folic acid and derivative biosynthesis|folic acid and derivative biosynthetic process|folic acid-containing compound anabolism|folic acid-containing compound biosynthesis|folic acid-containing compound formation|folic acid-containing compound synthesis|vitamin B9 and derivative biosynthesis|vitamin B9 and derivative biosynthetic process|vitamin M and derivative biosynthesis|vitamin M and derivative biosynthetic process http://purl.obolibrary.org/obo/GO_0009396 GO:0010385 biolink:MolecularActivity double-stranded methylated DNA binding Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. go.json http://purl.obolibrary.org/obo/GO_0010385 GO:0034352 biolink:BiologicalProcess positive regulation of glial cell apoptotic process Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. go.json activation of glial cell apoptosis|positive regulation of glial cell apoptosis|stimulation of glial cell apoptosis|up regulation of glial cell apoptosis|up-regulation of glial cell apoptosis|upregulation of glial cell apoptosis http://purl.obolibrary.org/obo/GO_0034352 GO:0034353 biolink:MolecularActivity mRNA 5'-diphosphatase activity Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end. go.json RNA pyrophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0034353 GO:0009397 biolink:BiologicalProcess folic acid-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives. go.json folate and derivative catabolic process|folate and derivative catabolism|folate-containing compound catabolic process|folate-containing compound catabolism|folic acid and derivative catabolic process|folic acid and derivative catabolism|folic acid-containing compound breakdown|folic acid-containing compound catabolism|folic acid-containing compound degradation|vitamin B9 and derivative catabolic process|vitamin B9 and derivative catabolism|vitamin M and derivative catabolic process|vitamin M and derivative catabolism http://purl.obolibrary.org/obo/GO_0009397 GO:0010386 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010386 GO:0009398 biolink:BiologicalProcess FMN biosynthetic process The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. go.json FMN anabolism|FMN biosynthesis|FMN formation|FMN synthesis http://purl.obolibrary.org/obo/GO_0009398 GO:0034354 biolink:BiologicalProcess 'de novo' NAD biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. go.json de novo NAD biosynthetic process from tryptophan http://purl.obolibrary.org/obo/GO_0034354 GO:0010383 biolink:BiologicalProcess cell wall polysaccharide metabolic process The chemical reactions and pathways involving cell wall polysaccharides. go.json http://purl.obolibrary.org/obo/GO_0010383 GO:0009399 biolink:BiologicalProcess nitrogen fixation The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide. MetaCyc:N2FIX-PWY|Wikipedia:Nitrogen_fixation go.json http://purl.obolibrary.org/obo/GO_0009399 GO:0010384 biolink:BiologicalProcess cell wall proteoglycan metabolic process The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates. go.json cell wall proteoglycan metabolism http://purl.obolibrary.org/obo/GO_0010384 GO:0034355 biolink:BiologicalProcess NAD salvage Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam). go.json NAD salvage pathway http://purl.obolibrary.org/obo/GO_0034355 GO:0010389 biolink:BiologicalProcess regulation of G2/M transition of mitotic cell cycle Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. go.json regulation of mitotic entry http://purl.obolibrary.org/obo/GO_0010389 GO:0034356 biolink:BiologicalProcess NAD biosynthesis via nicotinamide riboside salvage pathway The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside. go.json NR salvage pathway|nicotinamide riboside salvage pathway http://purl.obolibrary.org/obo/GO_0034356 GO:0034357 biolink:CellularComponent photosynthetic membrane A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place. go.json http://purl.obolibrary.org/obo/GO_0034357 GO:0034358 biolink:CellularComponent plasma lipoprotein particle A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0034358 GO:0010387 biolink:BiologicalProcess COP9 signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. go.json signalosome assembly http://purl.obolibrary.org/obo/GO_0010387 GO:0010388 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010388 GO:0034359 biolink:CellularComponent mature chylomicron A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph. go.json http://purl.obolibrary.org/obo/GO_0034359 GO:0010381 biolink:BiologicalProcess peroxisome-chloroplast membrane tethering The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. go.json attachment of peroxisome to chloroplast http://purl.obolibrary.org/obo/GO_0010381 GO:0010382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010382 GO:0034350 biolink:BiologicalProcess regulation of glial cell apoptotic process Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. go.json regulation of glial cell apoptosis http://purl.obolibrary.org/obo/GO_0034350 GO:0010380 biolink:BiologicalProcess regulation of chlorophyll biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. go.json http://purl.obolibrary.org/obo/GO_0010380 GO:0034351 biolink:BiologicalProcess negative regulation of glial cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. go.json down regulation of glial cell apoptosis|down-regulation of glial cell apoptosis|downregulation of glial cell apoptosis|inhibition of glial cell apoptosis|negative regulation of glial cell apoptosis http://purl.obolibrary.org/obo/GO_0034351 GO:0034349 biolink:BiologicalProcess glial cell apoptotic process Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. go.json apoptosis of glia|apoptosis of glial cells|glia apoptosis|glia programmed cell death by apoptosis|glial cell apoptosis|glial cell programmed cell death by apoptosis|programmed cell death of glia by apoptosis|programmed cell death of glial cells by apoptosis|programmed cell death, glia|programmed cell death, glial cells http://purl.obolibrary.org/obo/GO_0034349 GO:0010396 biolink:BiologicalProcess rhamnogalacturonan II metabolic process The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues. go.json rhamnogalacturonan II metabolism http://purl.obolibrary.org/obo/GO_0010396 GO:0034341 biolink:BiologicalProcess response to type II interferon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. go.json response to gamma-interferon|response to immune interferon|response to interferon-gamma|response to type II IFN http://purl.obolibrary.org/obo/GO_0034341 GO:0034342 biolink:BiologicalProcess response to type III interferon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. go.json response to interferon-lambda|response to type III IFN http://purl.obolibrary.org/obo/GO_0034342 GO:0010397 biolink:BiologicalProcess apiogalacturonan metabolic process The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links. go.json apiogalacturonan metabolism http://purl.obolibrary.org/obo/GO_0010397 GO:0034343 biolink:BiologicalProcess type III interferon production The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far. go.json type III IFN production|type III interferon secretion http://purl.obolibrary.org/obo/GO_0034343 GO:0010394 biolink:BiologicalProcess homogalacturonan metabolic process The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. go.json homogalacturonan metabolism http://purl.obolibrary.org/obo/GO_0010394 GO:0034344 biolink:BiologicalProcess regulation of type III interferon production Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far. go.json regulation of type III IFN production http://purl.obolibrary.org/obo/GO_0034344 GO:0010395 biolink:BiologicalProcess rhamnogalacturonan I metabolic process The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone. go.json RGI metabolism|rhamnogalacturonan I metabolism http://purl.obolibrary.org/obo/GO_0010395 GO:0034345 biolink:BiologicalProcess negative regulation of type III interferon production Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far. go.json down regulation of type III interferon production|down-regulation of type III interferon production|downregulation of type III interferon production|inhibition of type III interferon production|negative regulation of type III IFN production http://purl.obolibrary.org/obo/GO_0034345 GO:0034346 biolink:BiologicalProcess positive regulation of type III interferon production Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far. go.json activation of type III interferon production|positive regulation of type III IFN production|stimulation of type III interferon production|up regulation of type III interferon production|up-regulation of type III interferon production|upregulation of type III interferon production http://purl.obolibrary.org/obo/GO_0034346 GO:0034347 biolink:MolecularActivity type III interferon binding Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far. go.json interferon-lambda binding http://purl.obolibrary.org/obo/GO_0034347 GO:0010398 biolink:BiologicalProcess xylogalacturonan metabolic process The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues. go.json xylogalacturonan metabolism http://purl.obolibrary.org/obo/GO_0010398 GO:0010399 biolink:BiologicalProcess rhamnogalacturonan I backbone metabolic process The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone. go.json rhamnogalacturonan I backbone metabolism http://purl.obolibrary.org/obo/GO_0010399 GO:0034348 biolink:MolecularActivity type III interferon receptor activity Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far. go.json interferon-lambda receptor activity http://purl.obolibrary.org/obo/GO_0034348 GO:0010392 biolink:BiologicalProcess galactoglucomannan metabolic process The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units. go.json galactoglucomannan metabolism http://purl.obolibrary.org/obo/GO_0010392 GO:0010393 biolink:BiologicalProcess galacturonan metabolic process The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues. go.json galacturonan metabolism http://purl.obolibrary.org/obo/GO_0010393 GO:0010390 biolink:BiologicalProcess histone monoubiquitination The modification of histones by addition of a single ubiquitin group. go.json http://purl.obolibrary.org/obo/GO_0010390 gocheck_do_not_annotate GO:0010391 biolink:BiologicalProcess glucomannan metabolic process The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units. go.json glucomannan metabolism http://purl.obolibrary.org/obo/GO_0010391 GO:0034340 biolink:BiologicalProcess response to type I interferon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json response to type I IFN http://purl.obolibrary.org/obo/GO_0034340 GO:0010525 biolink:BiologicalProcess obsolete regulation of transposition, RNA-mediated OBSOLETE. Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. go.json True http://purl.obolibrary.org/obo/GO_0010525 GO:0010526 biolink:BiologicalProcess retrotransposon silencing Any process that decreases the frequency, rate or extent of retrotransposition. Retrotransposons are a subset of transposable elements that use an RNA intermediate and reverse transcribe themselves into the genome. Wikipedia:Retrotransposon_silencing go.json negative regulation of transposition, RNA-mediated http://purl.obolibrary.org/obo/GO_0010526 GO:0010523 biolink:BiologicalProcess negative regulation of calcium ion transport into cytosol Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. go.json http://purl.obolibrary.org/obo/GO_0010523 GO:0010524 biolink:BiologicalProcess positive regulation of calcium ion transport into cytosol Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. go.json http://purl.obolibrary.org/obo/GO_0010524 GO:0010529 biolink:BiologicalProcess obsolete negative regulation of transposition OBSOLETE. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. go.json True http://purl.obolibrary.org/obo/GO_0010529 GO:0010527 biolink:BiologicalProcess obsolete positive regulation of transposition, RNA-mediated OBSOLETE. Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. go.json True http://purl.obolibrary.org/obo/GO_0010527 GO:0010528 biolink:BiologicalProcess obsolete regulation of transposition OBSOLETE. Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. go.json True http://purl.obolibrary.org/obo/GO_0010528 GO:0009530 biolink:CellularComponent primary cell wall A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present. go.json http://purl.obolibrary.org/obo/GO_0009530 GO:0009531 biolink:CellularComponent secondary cell wall A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin. Wikipedia:Secondary_cell_wall go.json http://purl.obolibrary.org/obo/GO_0009531 GO:0009532 biolink:CellularComponent plastid stroma The proteinaceous ground substance of plastids. go.json http://purl.obolibrary.org/obo/GO_0009532 GO:0010521 biolink:MolecularActivity telomerase inhibitor activity Binds to and stops, prevents or reduces the activity of telomerase. go.json http://purl.obolibrary.org/obo/GO_0010521 GO:0009533 biolink:CellularComponent chloroplast stromal thylakoid Unstacked thylakoids that connect the grana stacks through the stroma. go.json http://purl.obolibrary.org/obo/GO_0009533 GO:0010522 biolink:BiologicalProcess regulation of calcium ion transport into cytosol Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. go.json http://purl.obolibrary.org/obo/GO_0010522 GO:0009534 biolink:CellularComponent chloroplast thylakoid Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0009534 GO:0010520 biolink:BiologicalProcess regulation of reciprocal meiotic recombination Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010520 GO:0009535 biolink:CellularComponent chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0009535 GO:0009536 biolink:CellularComponent plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. Wikipedia:Plastid go.json http://purl.obolibrary.org/obo/GO_0009536 goslim_chembl|goslim_generic|goslim_pir|goslim_plant GO:0009537 biolink:CellularComponent proplastid The precursor of other plastids. go.json http://purl.obolibrary.org/obo/GO_0009537 GO:0009538 biolink:CellularComponent photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. go.json photosystem I reaction centre http://purl.obolibrary.org/obo/GO_0009538 GO:0009539 biolink:CellularComponent photosystem II reaction center An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone. go.json photosystem II reaction centre http://purl.obolibrary.org/obo/GO_0009539 GO:0010536 biolink:BiologicalProcess positive regulation of activation of Janus kinase activity Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. go.json positive regulation of activation of JAK protein|positive regulation of activation of JAK1 kinase activity|positive regulation of activation of JAK1 protein|positive regulation of activation of JAK2 kinase activity|positive regulation of activation of JAK2 protein|positive regulation of tyrosine phosphorylation of JAK protein|positive regulation of tyrosine phosphorylation of JAK1 protein|positive regulation of tyrosine phosphorylation of JAK2 protein http://purl.obolibrary.org/obo/GO_0010536 gocheck_do_not_annotate GO:0010537 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010537 GO:0010534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010534 GO:0010535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010535 GO:0010538 biolink:MolecularActivity obsolete Hsp27 protein regulator activity OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone. go.json Hsp27 protein regulator activity True http://purl.obolibrary.org/obo/GO_0010538 GO:0010539 biolink:MolecularActivity obsolete Hsp27 protein inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone. go.json Hsp27 protein inhibitor activity True http://purl.obolibrary.org/obo/GO_0010539 GO:0009540 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009540 GO:0009541 biolink:CellularComponent etioplast prolamellar body A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast. go.json http://purl.obolibrary.org/obo/GO_0009541 GO:0009542 biolink:CellularComponent granum Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0009542 GO:0010532 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010532 GO:0009543 biolink:CellularComponent chloroplast thylakoid lumen The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0009543 GO:0010533 biolink:BiologicalProcess regulation of activation of Janus kinase activity Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. go.json regulation of activation of JAK protein|regulation of activation of JAK1 kinase activity|regulation of activation of JAK1 protein|regulation of activation of JAK2 kinase activity|regulation of activation of JAK2 protein|regulation of tyrosine phosphorylation of JAK protein|regulation of tyrosine phosphorylation of JAK1 protein|regulation of tyrosine phosphorylation of JAK2 protein http://purl.obolibrary.org/obo/GO_0010533 gocheck_do_not_annotate GO:0009544 biolink:CellularComponent chloroplast ATP synthase complex The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts. go.json http://purl.obolibrary.org/obo/GO_0009544 GO:0009545 biolink:CellularComponent elaioplast A leucoplast in which oil is stored. Wikipedia:Elaioplast go.json http://purl.obolibrary.org/obo/GO_0009545 GO:0010530 biolink:BiologicalProcess obsolete positive regulation of transposition OBSOLETE. Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. go.json True http://purl.obolibrary.org/obo/GO_0010530 GO:0010531 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010531 GO:0009546 biolink:CellularComponent plasmodesmatal cytoplasmic sleeve The space between the plasma membrane and the desmotubule of a plasmodesma. go.json plasmodesmatal cytoplasmic annulus http://purl.obolibrary.org/obo/GO_0009546 GO:0009547 biolink:CellularComponent plastid ribosome A ribosome contained within a plastid. go.json http://purl.obolibrary.org/obo/GO_0009547 GO:0009548 biolink:CellularComponent plasmodesmatal plasma membrane The portion of the plasma membrane surrounding a plasmodesma. go.json http://purl.obolibrary.org/obo/GO_0009548 GO:0009549 biolink:CellularComponent cellulose microfibril A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell. go.json http://purl.obolibrary.org/obo/GO_0009549 GO:0010509 biolink:BiologicalProcess intracellular polyamine homeostasis A homeostatic process involved in the maintenance of a steady state level of polyamine within a cell. go.json polyamine homeostasis http://purl.obolibrary.org/obo/GO_0010509 GO:0010503 biolink:BiologicalProcess obsolete negative regulation of cell cycle arrest in response to nitrogen starvation OBSOLETE. Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation. go.json True http://purl.obolibrary.org/obo/GO_0010503 GO:0010504 biolink:BiologicalProcess obsolete regulation of cell cycle arrest in response to nitrogen starvation OBSOLETE. Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation. go.json True http://purl.obolibrary.org/obo/GO_0010504 GO:0010501 biolink:BiologicalProcess RNA secondary structure unwinding The process in which a secondary structure of RNA are broken or 'melted'. go.json RNA duplex unwinding http://purl.obolibrary.org/obo/GO_0010501 GO:0010502 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010502 GO:0010507 biolink:BiologicalProcess negative regulation of autophagy Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0010507 GO:0010508 biolink:BiologicalProcess positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0010508 GO:0010505 biolink:BiologicalProcess obsolete positive regulation of cell cycle arrest in response to nitrogen starvation OBSOLETE. Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation. go.json True http://purl.obolibrary.org/obo/GO_0010505 GO:0010506 biolink:BiologicalProcess regulation of autophagy Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0010506 GO:0009510 biolink:CellularComponent plasmodesmatal desmotubule A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell. go.json desmotubule central rod http://purl.obolibrary.org/obo/GO_0009510 GO:0010500 biolink:BiologicalProcess transmitting tissue development The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary. go.json http://purl.obolibrary.org/obo/GO_0010500 GO:0009511 biolink:CellularComponent plasmodesmatal endoplasmic reticulum Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells. go.json plasmodesmatal ER http://purl.obolibrary.org/obo/GO_0009511 GO:0009512 biolink:CellularComponent cytochrome b6f complex Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. Wikipedia:Cytochrome_b6f_complex go.json cyt b(6)f complex|cyt b6-f complex|cyt b6/f complex|cyt b6f complex|cytochrome b(6)f complex|cytochrome b6-f complex|cytochrome b6/f complex http://purl.obolibrary.org/obo/GO_0009512 GO:0009513 biolink:CellularComponent etioplast A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions. Wikipedia:Etioplast go.json http://purl.obolibrary.org/obo/GO_0009513 GO:0009514 biolink:CellularComponent glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds. Wikipedia:Glyoxysome go.json http://purl.obolibrary.org/obo/GO_0009514 GO:0009515 biolink:CellularComponent granal stacked thylakoid Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II. go.json chloroplast stacked thylakoid http://purl.obolibrary.org/obo/GO_0009515 GO:0009516 biolink:CellularComponent leucoplast A colorless plastid involved in the synthesis of monoterpenes. Wikipedia:Leucoplast go.json http://purl.obolibrary.org/obo/GO_0009516 GO:0009517 biolink:CellularComponent PSII associated light-harvesting complex II Protein-pigment complex associated with photosystem II. go.json LHCII http://purl.obolibrary.org/obo/GO_0009517 GO:0009518 biolink:CellularComponent PSI associated light-harvesting complex I Protein-pigment complex associated with photosystem I. go.json LHCI http://purl.obolibrary.org/obo/GO_0009518 GO:0009519 biolink:CellularComponent middle lamella Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells. Wikipedia:Middle_lamella go.json http://purl.obolibrary.org/obo/GO_0009519 GO:0010514 biolink:BiologicalProcess induction of conjugation with cellular fusion The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types. go.json http://purl.obolibrary.org/obo/GO_0010514 GO:0010515 biolink:BiologicalProcess negative regulation of induction of conjugation with cellular fusion Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0010515 GO:0010512 biolink:BiologicalProcess negative regulation of phosphatidylinositol biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. go.json http://purl.obolibrary.org/obo/GO_0010512 GO:0010513 biolink:BiologicalProcess positive regulation of phosphatidylinositol biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. go.json http://purl.obolibrary.org/obo/GO_0010513 GO:0010518 biolink:BiologicalProcess positive regulation of phospholipase activity Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. go.json http://purl.obolibrary.org/obo/GO_0010518 gocheck_do_not_annotate GO:0010519 biolink:BiologicalProcess negative regulation of phospholipase activity Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. go.json http://purl.obolibrary.org/obo/GO_0010519 gocheck_do_not_annotate GO:0010516 biolink:BiologicalProcess negative regulation of cellular response to nitrogen starvation Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation. go.json http://purl.obolibrary.org/obo/GO_0010516 GO:0010517 biolink:BiologicalProcess regulation of phospholipase activity Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. go.json http://purl.obolibrary.org/obo/GO_0010517 gocheck_do_not_annotate GO:0009520 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009520 GO:0009521 biolink:CellularComponent photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. Wikipedia:Photosystem go.json reaction center|reaction centre http://purl.obolibrary.org/obo/GO_0009521 goslim_pir GO:0010510 biolink:BiologicalProcess regulation of acetyl-CoA biosynthetic process from pyruvate Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. go.json http://purl.obolibrary.org/obo/GO_0010510 GO:0010511 biolink:BiologicalProcess regulation of phosphatidylinositol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. go.json http://purl.obolibrary.org/obo/GO_0010511 GO:0009522 biolink:CellularComponent photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). go.json http://purl.obolibrary.org/obo/GO_0009522 GO:0009523 biolink:CellularComponent photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. Wikipedia:Photosystem_II go.json http://purl.obolibrary.org/obo/GO_0009523 GO:0009524 biolink:CellularComponent phragmoplast The phragmoplast is a plant cell specific cytoplasmic structure composed of cytoskeletal polymers, membranes, and associated cytosolic proteins that functions as the focused secretory module for assembling the cell plate. Wikipedia:Phragmoplast go.json http://purl.obolibrary.org/obo/GO_0009524 GO:0009525 biolink:CellularComponent phragmosome A flattened membranous vesicle containing cell wall components. Wikipedia:Phragmosome go.json http://purl.obolibrary.org/obo/GO_0009525 GO:0009526 biolink:CellularComponent plastid envelope The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0009526 GO:0009527 biolink:CellularComponent plastid outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope. go.json http://purl.obolibrary.org/obo/GO_0009527 GO:0009528 biolink:CellularComponent plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. go.json http://purl.obolibrary.org/obo/GO_0009528 GO:0009529 biolink:CellularComponent plastid intermembrane space The region between the inner and outer lipid bilayers of the plastid envelope. go.json plastid envelope lumen http://purl.obolibrary.org/obo/GO_0009529 GO:0009500 biolink:MolecularActivity obsolete dicluster bacterial-type ferredoxin OBSOLETE. (Was not defined before being made obsolete). go.json dicluster bacterial-type ferredoxin True http://purl.obolibrary.org/obo/GO_0009500 GO:0009501 biolink:CellularComponent amyloplast A plastid whose main function is to synthesize and store starch. Wikipedia:Amyloplast go.json http://purl.obolibrary.org/obo/GO_0009501 GO:0009502 biolink:CellularComponent obsolete photosynthetic electron transport chain OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen). go.json photosynthetic electron transport chain True http://purl.obolibrary.org/obo/GO_0009502 GO:0009503 biolink:CellularComponent thylakoid light-harvesting complex A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0009503 GO:0009504 biolink:CellularComponent cell plate The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells. Wikipedia:Cell_plate go.json http://purl.obolibrary.org/obo/GO_0009504 GO:0009505 biolink:CellularComponent plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. go.json cellulose and pectin-containing cell wall|plant cell wall http://purl.obolibrary.org/obo/GO_0009505 GO:0009506 biolink:CellularComponent plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. Wikipedia:Plasmodesma go.json plasmodesmata http://purl.obolibrary.org/obo/GO_0009506 GO:0009507 biolink:CellularComponent chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. Wikipedia:Chloroplast go.json http://purl.obolibrary.org/obo/GO_0009507 goslim_plant GO:0009508 biolink:CellularComponent plastid chromosome A circular DNA molecule containing plastid encoded genes. go.json http://purl.obolibrary.org/obo/GO_0009508 GO:0009509 biolink:CellularComponent chromoplast A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments. Wikipedia:Chromoplast go.json http://purl.obolibrary.org/obo/GO_0009509 GO:0034572 biolink:MolecularActivity monodemethylisoproturon dimethylaminedehydrogenase activity Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-. EC:1.5.99.-|UM-BBD_reactionID:r0897 go.json http://purl.obolibrary.org/obo/GO_0034572 GO:0034573 biolink:MolecularActivity didemethylisoproturon amidohydrolase activity Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline. UM-BBD_reactionID:r0898 go.json http://purl.obolibrary.org/obo/GO_0034573 GO:0034574 biolink:MolecularActivity didemethylisoproturon dehydrogenase activity Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-. EC:1.17.99.-|UM-BBD_reactionID:r0899 go.json http://purl.obolibrary.org/obo/GO_0034574 GO:0034575 biolink:MolecularActivity 4-isopropylaniline dehydrogenase activity Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-. EC:1.17.99.-|UM-BBD_reactionID:r0901 go.json http://purl.obolibrary.org/obo/GO_0034575 GO:0034576 biolink:MolecularActivity N-isopropylacetanilide amidohydrolase activity Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate. UM-BBD_reactionID:r0913 go.json http://purl.obolibrary.org/obo/GO_0034576 GO:0034577 biolink:MolecularActivity N-isopropylacetaniline monooxygenase activity Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone. EC:1.14.15.-|UM-BBD_reactionID:r0914 go.json http://purl.obolibrary.org/obo/GO_0034577 GO:0034578 biolink:MolecularActivity limonene 8-hydratase activity Catalysis of the reaction: limonene + H2O = alpha-terpineol. UM-BBD_reactionID:r0916 go.json http://purl.obolibrary.org/obo/GO_0034578 GO:0034579 biolink:MolecularActivity (1-methylpentyl)succinate synthase activity Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate. UM-BBD_reactionID:r0920 go.json http://purl.obolibrary.org/obo/GO_0034579 GO:0034570 biolink:MolecularActivity hydroxymonomethylisoproturon dimethylaminedehydrogenase activity Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-. EC:1.5.99.-|UM-BBD_reactionID:r0894 go.json http://purl.obolibrary.org/obo/GO_0034570 GO:0034571 biolink:MolecularActivity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid. UM-BBD_reactionID:r0895 go.json http://purl.obolibrary.org/obo/GO_0034571 GO:0034569 biolink:MolecularActivity monodemethylisoproturon dehydrogenase activity Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-. EC:1.17.99.-|UM-BBD_reactionID:r0893 go.json http://purl.obolibrary.org/obo/GO_0034569 GO:0034561 biolink:MolecularActivity 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O. UM-BBD_reactionID:r0862 go.json http://purl.obolibrary.org/obo/GO_0034561 GO:0034562 biolink:MolecularActivity 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O. UM-BBD_reactionID:r0864 go.json http://purl.obolibrary.org/obo/GO_0034562 GO:0034563 biolink:MolecularActivity 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-. UM-BBD_reactionID:r0867 go.json http://purl.obolibrary.org/obo/GO_0034563 GO:0034564 biolink:MolecularActivity 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-. UM-BBD_reactionID:r0866 go.json http://purl.obolibrary.org/obo/GO_0034564 GO:0034565 biolink:MolecularActivity 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol. EC:3.5.99.-|UM-BBD_reactionID:r0872 go.json http://purl.obolibrary.org/obo/GO_0034565 GO:0034566 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034566 GO:0034567 biolink:MolecularActivity chromate reductase activity Catalysis of the reaction: chromate = chromium (III). EC:1.97.1.-|UM-BBD_reactionID:r0884 go.json http://purl.obolibrary.org/obo/GO_0034567 GO:0034568 biolink:MolecularActivity isoproturon dimethylaminedehydrogenase activity Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-. EC:1.5.99.-|UM-BBD_reactionID:r0892 go.json http://purl.obolibrary.org/obo/GO_0034568 GO:0034560 biolink:MolecularActivity bisphenol A hydroxylase A activity Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O. EC:1.14.13.-|UM-BBD_reactionID:r0861 go.json http://purl.obolibrary.org/obo/GO_0034560 GO:0034558 biolink:MolecularActivity technetium (VII) reductase activity Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-. UM-BBD_reactionID:r0859 go.json http://purl.obolibrary.org/obo/GO_0034558 GO:0034559 biolink:MolecularActivity bisphenol A hydroxylase B activity Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O. UM-BBD_reactionID:r0860 go.json http://purl.obolibrary.org/obo/GO_0034559 GO:0010589 biolink:BiologicalProcess leaf proximal/distal pattern formation The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis. go.json http://purl.obolibrary.org/obo/GO_0010589 GO:0034550 biolink:MolecularActivity dimethylarsinate reductase activity Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O. EC:1.97.1.-|UM-BBD_reactionID:r0838 go.json http://purl.obolibrary.org/obo/GO_0034550 GO:0010583 biolink:BiologicalProcess response to cyclopentenone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid. go.json http://purl.obolibrary.org/obo/GO_0010583 GO:0009594 biolink:BiologicalProcess detection of nutrient The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal. go.json detection of nutrients|nutrient sensing|perception of nutrients http://purl.obolibrary.org/obo/GO_0009594 GO:0010584 biolink:BiologicalProcess pollen exine formation The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine. go.json http://purl.obolibrary.org/obo/GO_0010584 GO:0034551 biolink:BiologicalProcess mitochondrial respiratory chain complex III assembly The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane. go.json mitochondrial cytochrome bc(1) complex assembly http://purl.obolibrary.org/obo/GO_0034551 GO:0009595 biolink:BiologicalProcess detection of biotic stimulus The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. go.json perception of biotic stimulus http://purl.obolibrary.org/obo/GO_0009595 GO:0010581 biolink:BiologicalProcess regulation of starch biosynthetic process An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch. go.json http://purl.obolibrary.org/obo/GO_0010581 GO:0034552 biolink:BiologicalProcess respiratory chain complex II assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. go.json http://purl.obolibrary.org/obo/GO_0034552 GO:0009596 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009596 GO:0010582 biolink:BiologicalProcess floral meristem determinacy The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). go.json http://purl.obolibrary.org/obo/GO_0010582 GO:0034553 biolink:BiologicalProcess mitochondrial respiratory chain complex II assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane. go.json http://purl.obolibrary.org/obo/GO_0034553 GO:0009597 biolink:BiologicalProcess detection of virus The series of events in which a stimulus from a virus is received and converted into a molecular signal. go.json perception of virus http://purl.obolibrary.org/obo/GO_0009597 GO:0010587 biolink:BiologicalProcess miRNA catabolic process The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. go.json microRNA catabolic process http://purl.obolibrary.org/obo/GO_0010587 GO:0009598 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009598 GO:0034554 biolink:MolecularActivity 3,3',5-tribromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr. EC:1.97.1.-|UM-BBD_reactionID:r0842 go.json http://purl.obolibrary.org/obo/GO_0034554 GO:0009599 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009599 GO:0010588 biolink:BiologicalProcess cotyledon vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants. go.json http://purl.obolibrary.org/obo/GO_0010588 GO:0034555 biolink:MolecularActivity 3,3'-dibromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr. EC:1.97.1.-|UM-BBD_reactionID:r0844 go.json http://purl.obolibrary.org/obo/GO_0034555 GO:0010585 biolink:BiologicalProcess glutamine secretion The controlled release of glutamine by a cell. go.json http://purl.obolibrary.org/obo/GO_0010585 GO:0034556 biolink:MolecularActivity nitrobenzoate nitroreductase activity Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+. UM-BBD_reactionID:r0849 go.json http://purl.obolibrary.org/obo/GO_0034556 GO:0034557 biolink:MolecularActivity 2-hydroxylaminobenzoate reductase activity Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O. MetaCyc:RXN-8848|UM-BBD_reactionID:r0850 go.json o-hydroxylaminobenzoate nitroreductase activity http://purl.obolibrary.org/obo/GO_0034557 GO:0010586 biolink:BiologicalProcess miRNA metabolic process The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. go.json microRNA metabolic process http://purl.obolibrary.org/obo/GO_0010586 goslim_drosophila GO:0010580 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010580 GO:0034547 biolink:MolecularActivity N-cyclopropylmelamine deaminase activity Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3. MetaCyc:RXN-8018|UM-BBD_reactionID:r0825 go.json http://purl.obolibrary.org/obo/GO_0034547 GO:0034548 biolink:MolecularActivity N-cyclopropylammeline deaminase activity Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3. MetaCyc:RXN-8019|UM-BBD_reactionID:r0826 go.json http://purl.obolibrary.org/obo/GO_0034548 GO:0034549 biolink:MolecularActivity N-cyclopropylammelide alkylamino hydrolase activity Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid. KEGG_REACTION:R06972|MetaCyc:RXN-8020|UM-BBD_reactionID:r0827 go.json http://purl.obolibrary.org/obo/GO_0034549 GO:0010594 biolink:BiologicalProcess regulation of endothelial cell migration Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. go.json http://purl.obolibrary.org/obo/GO_0010594 GO:0010595 biolink:BiologicalProcess positive regulation of endothelial cell migration Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. go.json http://purl.obolibrary.org/obo/GO_0010595 GO:0034540 biolink:MolecularActivity 3-monobromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr. EC:1.97.1.-|UM-BBD_reactionID:r0824 go.json http://purl.obolibrary.org/obo/GO_0034540 GO:0010592 biolink:BiologicalProcess positive regulation of lamellipodium assembly Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. go.json positive regulation of lamellipodium biogenesis http://purl.obolibrary.org/obo/GO_0010592 GO:0034541 biolink:MolecularActivity dimethylarsinite methyltransferase activity Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH. UM-BBD_reactionID:r0806 go.json http://purl.obolibrary.org/obo/GO_0034541 GO:0010593 biolink:BiologicalProcess negative regulation of lamellipodium assembly Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. go.json negative regulation of lamellipodium biogenesis http://purl.obolibrary.org/obo/GO_0010593 GO:0034542 biolink:MolecularActivity trimethylarsine oxidase activity Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O. EC:1.97.1.-|UM-BBD_reactionID:r0807 go.json http://purl.obolibrary.org/obo/GO_0034542 GO:0034543 biolink:MolecularActivity 5-aminosalicylate dioxygenase activity Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate. EC:1.13.11.-|UM-BBD_reactionID:r0809 go.json http://purl.obolibrary.org/obo/GO_0034543 GO:0010598 biolink:CellularComponent NAD(P)H dehydrogenase complex (plastoquinone) Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool. go.json http://purl.obolibrary.org/obo/GO_0010598 GO:0010599 biolink:BiologicalProcess lsiRNA processing A process leading to the generation of a functional long small interfering RNA (lsiRNA). lsiRNAs are class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions. go.json RNA interference, production of lsiRNA|primary lsiRNA processing|production of lsiRNA involved in RNA interference http://purl.obolibrary.org/obo/GO_0010599 GO:0034544 biolink:MolecularActivity trans-ACOHDA hydrolase activity Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3. EC:3.5.99.-|UM-BBD_reactionID:r0810 go.json http://purl.obolibrary.org/obo/GO_0034544 GO:0034545 biolink:MolecularActivity fumarylpyruvate hydrolase activity Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+. EC:3.7.1.20|RHEA:26168|UM-BBD_reactionID:r0811 go.json http://purl.obolibrary.org/obo/GO_0034545 GO:0010596 biolink:BiologicalProcess negative regulation of endothelial cell migration Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. go.json http://purl.obolibrary.org/obo/GO_0010596 GO:0034546 biolink:MolecularActivity 2,4-dichloroaniline reductive dehalogenase activity Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl. EC:1.97.1.-|UM-BBD_reactionID:r0819 go.json http://purl.obolibrary.org/obo/GO_0034546 GO:0010597 biolink:BiologicalProcess green leaf volatile biosynthetic process The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid. go.json http://purl.obolibrary.org/obo/GO_0010597 GO:0010590 biolink:BiologicalProcess regulation of septum digestion after cytokinesis Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. go.json regulation of cell separation after cytokinesis|regulation of cell separation following cytokinesis|regulation of mitotic cytokinetic cell separation http://purl.obolibrary.org/obo/GO_0010590 GO:0010591 biolink:BiologicalProcess regulation of lamellipodium assembly Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. go.json regulation of lamellipodium biogenesis http://purl.obolibrary.org/obo/GO_0010591 GO:0034536 biolink:MolecularActivity 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate. EC:5.3.99.-|UM-BBD_reactionID:r0782 go.json http://purl.obolibrary.org/obo/GO_0034536 GO:0010569 biolink:BiologicalProcess regulation of double-strand break repair via homologous recombination Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. go.json http://purl.obolibrary.org/obo/GO_0010569 GO:0034537 biolink:MolecularActivity 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde. UM-BBD_reactionID:r0783 go.json http://purl.obolibrary.org/obo/GO_0034537 GO:0034538 biolink:MolecularActivity 3-methylsalicylaldehyde dehydrogenase activity Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+. UM-BBD_reactionID:r0784 go.json http://purl.obolibrary.org/obo/GO_0034538 GO:0010567 biolink:BiologicalProcess regulation of ketone catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0010567 GO:0010568 biolink:BiologicalProcess regulation of budding cell apical bud growth Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding. go.json http://purl.obolibrary.org/obo/GO_0010568 GO:0034539 biolink:MolecularActivity 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr. EC:1.97.1.-|UM-BBD_reactionID:r0821 go.json http://purl.obolibrary.org/obo/GO_0034539 GO:0009580 biolink:CellularComponent obsolete thylakoid (sensu Bacteria) OBSOLETE. (Was not defined before being made obsolete). go.json thylakoid (sensu Bacteria) True http://purl.obolibrary.org/obo/GO_0009580 GO:0009581 biolink:BiologicalProcess detection of external stimulus The series of events in which an external stimulus is received by a cell and converted into a molecular signal. go.json perception of external stimulus http://purl.obolibrary.org/obo/GO_0009581 GO:0009582 biolink:BiologicalProcess detection of abiotic stimulus The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. go.json perception of abiotic stimulus http://purl.obolibrary.org/obo/GO_0009582 GO:0010561 biolink:BiologicalProcess negative regulation of glycoprotein biosynthetic process Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. go.json http://purl.obolibrary.org/obo/GO_0010561 GO:0009572 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009572 GO:0009573 biolink:CellularComponent chloroplast ribulose bisphosphate carboxylase complex A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana. go.json chloroplast RubisCO complex http://purl.obolibrary.org/obo/GO_0009573 GO:0010562 biolink:BiologicalProcess positive regulation of phosphorus metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. go.json http://purl.obolibrary.org/obo/GO_0010562 GO:0034530 biolink:MolecularActivity 4-hydroxymethylsalicyaldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+. EC:1.2.1.-|UM-BBD_reactionID:r0767 go.json http://purl.obolibrary.org/obo/GO_0034530 GO:0009574 biolink:CellularComponent preprophase band A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs. Wikipedia:Preprophase_band go.json http://purl.obolibrary.org/obo/GO_0009574 GO:0034531 biolink:MolecularActivity 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde. UM-BBD_reactionID:r0766 go.json http://purl.obolibrary.org/obo/GO_0034531 GO:0010560 biolink:BiologicalProcess positive regulation of glycoprotein biosynthetic process Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. go.json http://purl.obolibrary.org/obo/GO_0010560 GO:0009575 biolink:CellularComponent chromoplast stroma The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material. go.json http://purl.obolibrary.org/obo/GO_0009575 GO:0034532 biolink:MolecularActivity 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate. EC:5.3.99.-|UM-BBD_reactionID:r0765 go.json http://purl.obolibrary.org/obo/GO_0034532 GO:0009576 biolink:CellularComponent leucoplast stroma The space enclosed by the double membrane of a leucoplast. go.json http://purl.obolibrary.org/obo/GO_0009576 GO:0010565 biolink:BiologicalProcess regulation of cellular ketone metabolic process Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. go.json http://purl.obolibrary.org/obo/GO_0010565 GO:0034533 biolink:MolecularActivity 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate. UM-BBD_reactionID:r0764 go.json http://purl.obolibrary.org/obo/GO_0034533 GO:0009577 biolink:CellularComponent elaioplast stroma The space enclosed by the double membrane of an elaioplast. go.json http://purl.obolibrary.org/obo/GO_0009577 GO:0010566 biolink:BiologicalProcess regulation of ketone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0010566 GO:0010563 biolink:BiologicalProcess negative regulation of phosphorus metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. go.json http://purl.obolibrary.org/obo/GO_0010563 GO:0034534 biolink:MolecularActivity 1-methylnaphthalene hydroxylase activity Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O. EC:1.14.13.-|UM-BBD_reactionID:r0795 go.json http://purl.obolibrary.org/obo/GO_0034534 GO:0009578 biolink:CellularComponent etioplast stroma The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA. go.json http://purl.obolibrary.org/obo/GO_0009578 GO:0034535 biolink:MolecularActivity 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+. UM-BBD_reactionID:r0781 go.json http://purl.obolibrary.org/obo/GO_0034535 GO:0009579 biolink:CellularComponent thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. Wikipedia:Thylakoid go.json photosynthetic membrane http://purl.obolibrary.org/obo/GO_0009579 goslim_chembl|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant|prokaryote_subset GO:0010564 biolink:BiologicalProcess regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. go.json http://purl.obolibrary.org/obo/GO_0010564 GO:0034525 biolink:MolecularActivity 1-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+. UM-BBD_reactionID:r0787 go.json http://purl.obolibrary.org/obo/GO_0034525 GO:0034526 biolink:MolecularActivity 2-methylnaphthalene hydroxylase activity Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O. EC:1.14.13.-|UM-BBD_reactionID:r0788 go.json http://purl.obolibrary.org/obo/GO_0034526 GO:0010578 biolink:BiologicalProcess regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway. go.json regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|regulation of adenylate cyclase activity involved in G-protein signaling pathway|regulation of adenylate cyclase activity involved in G-protein signalling http://purl.obolibrary.org/obo/GO_0010578 gocheck_do_not_annotate GO:0034527 biolink:MolecularActivity 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene. UM-BBD_reactionID:r0790 go.json http://purl.obolibrary.org/obo/GO_0034527 GO:0010579 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010579 GO:0034528 biolink:MolecularActivity 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate. EC:5.3.99.-|UM-BBD_reactionID:r0791 go.json http://purl.obolibrary.org/obo/GO_0034528 GO:0009590 biolink:BiologicalProcess detection of gravity The series of events in which a gravitational stimulus is received and converted into a molecular signal. go.json perception of gravity http://purl.obolibrary.org/obo/GO_0009590 GO:0034529 biolink:MolecularActivity 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate. UM-BBD_reactionID:r0792 go.json http://purl.obolibrary.org/obo/GO_0034529 GO:0009591 biolink:BiologicalProcess obsolete perception of mechanical stimulus OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal. go.json perception of mechanical stimulus True http://purl.obolibrary.org/obo/GO_0009591 GO:0009592 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009592 GO:0009593 biolink:BiologicalProcess detection of chemical stimulus The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. go.json chemoperception|chemoreception|detection of chemical substance|perception of chemical stimulus|perception of chemical substance http://purl.obolibrary.org/obo/GO_0009593 GO:0009583 biolink:BiologicalProcess detection of light stimulus The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. go.json detection of light|perception of light http://purl.obolibrary.org/obo/GO_0009583 GO:0010572 biolink:BiologicalProcess positive regulation of platelet activation Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. go.json http://purl.obolibrary.org/obo/GO_0010572 GO:0009584 biolink:BiologicalProcess detection of visible light The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. go.json perception of visible light http://purl.obolibrary.org/obo/GO_0009584 GO:0010573 biolink:BiologicalProcess vascular endothelial growth factor production The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json VEGF production http://purl.obolibrary.org/obo/GO_0010573 GO:0010570 biolink:BiologicalProcess regulation of filamentous growth Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0010570 GO:0009585 biolink:BiologicalProcess red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. go.json phytochrome signaling pathway|red-sensitive opsin http://purl.obolibrary.org/obo/GO_0009585 GO:0034520 biolink:MolecularActivity 2-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+. EC:1.2.1.-|UM-BBD_reactionID:r0772 go.json http://purl.obolibrary.org/obo/GO_0034520 GO:0010571 biolink:BiologicalProcess positive regulation of nuclear cell cycle DNA replication Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. go.json positive regulation of DNA replication during S phase|positive regulation of DNA replication involved in S phase|positive regulation of DNA replication involved in S-phase http://purl.obolibrary.org/obo/GO_0010571 GO:0009586 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009586 GO:0009587 biolink:BiologicalProcess obsolete phototrophin mediated phototransduction OBSOLETE. (Was not defined before being made obsolete). go.json phototrophin mediated phototransduction True http://purl.obolibrary.org/obo/GO_0009587 GO:0010576 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010576 GO:0034521 biolink:MolecularActivity 1-naphthoic acid dioxygenase activity Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+. EC:1.14.12.-|UM-BBD_reactionID:r0773 go.json http://purl.obolibrary.org/obo/GO_0034521 GO:0009588 biolink:BiologicalProcess UV-A, blue light phototransduction The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm. go.json blue-sensitive opsin|short-wave-sensitive opsin|violet-sensitive opsin http://purl.obolibrary.org/obo/GO_0009588 GO:0010577 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010577 GO:0034522 biolink:MolecularActivity cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-. UM-BBD_reactionID:r0774 go.json http://purl.obolibrary.org/obo/GO_0034522 GO:0010574 biolink:BiologicalProcess regulation of vascular endothelial growth factor production Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. go.json http://purl.obolibrary.org/obo/GO_0010574 GO:0009589 biolink:BiologicalProcess detection of UV The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. go.json detection of UV light stimulus|detection of UV radiation stimulus|detection of ultraviolet light stimulus|detection of ultraviolet radiation stimulus|perception of UV http://purl.obolibrary.org/obo/GO_0009589 GO:0034523 biolink:MolecularActivity 3-formylsalicylate oxidase activity Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide. UM-BBD_reactionID:r0777 go.json http://purl.obolibrary.org/obo/GO_0034523 GO:0034524 biolink:MolecularActivity 2-hydroxyisophthalate decarboxylase activity Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2. UM-BBD_reactionID:r0776 go.json http://purl.obolibrary.org/obo/GO_0034524 GO:0010575 biolink:BiologicalProcess positive regulation of vascular endothelial growth factor production Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. go.json http://purl.obolibrary.org/obo/GO_0010575 GO:0010547 biolink:BiologicalProcess thylakoid membrane disassembly The controlled breakdown of the thylakoid membrane in the context of a normal process. go.json thylakoid membrane degradation http://purl.obolibrary.org/obo/GO_0010547 GO:0034514 biolink:BiologicalProcess mitochondrial unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins. go.json mtUPR http://purl.obolibrary.org/obo/GO_0034514 GO:0034515 biolink:CellularComponent proteasome storage granule An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state. go.json PSG http://purl.obolibrary.org/obo/GO_0034515 GO:0010548 biolink:BiologicalProcess regulation of thylakoid membrane disassembly Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly. go.json regulation of thylakoid membrane degradation http://purl.obolibrary.org/obo/GO_0010548 GO:0010545 biolink:MolecularActivity obsolete Hsp90 protein regulator activity OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90. go.json Hsp90 protein regulator activity True http://purl.obolibrary.org/obo/GO_0010545 GO:0034516 biolink:BiologicalProcess response to vitamin B6 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0034516 GO:0010546 biolink:MolecularActivity obsolete Hsp90 protein inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone. go.json Hsp90 protein inhibitor activity True http://purl.obolibrary.org/obo/GO_0010546 GO:0034517 biolink:BiologicalProcess ribophagy The selective degradation of mature ribosomes by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0034517 GO:0034518 biolink:CellularComponent RNA cap binding complex A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation. go.json http://purl.obolibrary.org/obo/GO_0034518 GO:0034519 biolink:CellularComponent obsolete cytoplasmic RNA cap binding complex OBSOLETE. A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA. go.json True http://purl.obolibrary.org/obo/GO_0034519 GO:0010549 biolink:BiologicalProcess regulation of membrane disassembly Any process that modulates the frequency, rate or extent of membrane disassembly. go.json http://purl.obolibrary.org/obo/GO_0010549 GO:0009560 biolink:BiologicalProcess embryo sac egg cell differentiation The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana. go.json female gamete generation|female gametophyte egg cell differentiation http://purl.obolibrary.org/obo/GO_0009560 GO:0009550 biolink:CellularComponent primary plasmodesma A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis. go.json simple plasmodesma http://purl.obolibrary.org/obo/GO_0009550 GO:0009551 biolink:CellularComponent secondary plasmodesma A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata. go.json http://purl.obolibrary.org/obo/GO_0009551 GO:0010540 biolink:BiologicalProcess basipetal auxin transport The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root. go.json http://purl.obolibrary.org/obo/GO_0010540 GO:0009552 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009552 GO:0009553 biolink:BiologicalProcess embryo sac development The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate. go.json female gametophyte development http://purl.obolibrary.org/obo/GO_0009553 GO:0009554 biolink:BiologicalProcess megasporogenesis The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus. go.json megaspore development|megaspore mother cell meiosis|meiosis of the megasporocyte|meiotic division of the megasporocyte http://purl.obolibrary.org/obo/GO_0009554 GO:0010543 biolink:BiologicalProcess regulation of platelet activation Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. go.json http://purl.obolibrary.org/obo/GO_0010543 GO:0034510 biolink:BiologicalProcess centromere separation The cell cycle process in which centromeres are physically detached from each other during chromosome separation. go.json http://purl.obolibrary.org/obo/GO_0034510 GO:0009555 biolink:BiologicalProcess pollen development The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. go.json formation of generative and vegetative cells|male gametophyte development|male gametophyte formation|microgametophyte development|pollen grain formation http://purl.obolibrary.org/obo/GO_0009555 GO:0034511 biolink:MolecularActivity U3 snoRNA binding Binding to a U3 small nucleolar RNA. go.json http://purl.obolibrary.org/obo/GO_0034511 GO:0010544 biolink:BiologicalProcess negative regulation of platelet activation Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. go.json http://purl.obolibrary.org/obo/GO_0010544 GO:0034512 biolink:MolecularActivity box C/D RNA binding Binding to a box C/D small nucleolar RNA. go.json box C/D sRNA binding|box C/D snoRNA binding http://purl.obolibrary.org/obo/GO_0034512 GO:0009556 biolink:BiologicalProcess microsporogenesis The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores. go.json microspore development http://purl.obolibrary.org/obo/GO_0009556 GO:0010541 biolink:BiologicalProcess acropetal auxin transport The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root. go.json http://purl.obolibrary.org/obo/GO_0010541 GO:0034513 biolink:MolecularActivity box H/ACA snoRNA binding Binding to a box H/ACA small nucleolar RNA. go.json http://purl.obolibrary.org/obo/GO_0034513 GO:0009557 biolink:BiologicalProcess antipodal cell differentiation The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell. go.json http://purl.obolibrary.org/obo/GO_0009557 GO:0010542 biolink:MolecularActivity nitrate efflux transmembrane transporter activity Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane. go.json http://purl.obolibrary.org/obo/GO_0010542 GO:0009558 biolink:BiologicalProcess embryo sac cellularization The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana. go.json cellularization of the embryo sac|female gametophyte cellularization|megagametophyte cellularization http://purl.obolibrary.org/obo/GO_0009558 GO:0009559 biolink:BiologicalProcess embryo sac central cell differentiation The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell. go.json embryo sac endosperm mother cell differentiation|female gametophyte central cell differentiation http://purl.obolibrary.org/obo/GO_0009559 GO:0034503 biolink:BiologicalProcess protein localization to nucleolar rDNA repeats Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus. go.json condensin localization to nucleolar rDNA repeats|protein localisation to nucleolar rDNA repeats http://purl.obolibrary.org/obo/GO_0034503 GO:0010558 biolink:BiologicalProcess negative regulation of macromolecule biosynthetic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json http://purl.obolibrary.org/obo/GO_0010558 GO:0034504 biolink:BiologicalProcess protein localization to nucleus A process in which a protein transports or maintains the localization of another protein to the nucleus. go.json protein localisation to nucleus|protein localization in cell nucleus|protein localization in nucleus|protein targeting to nucleus http://purl.obolibrary.org/obo/GO_0034504 GO:0010559 biolink:BiologicalProcess regulation of glycoprotein biosynthetic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. go.json http://purl.obolibrary.org/obo/GO_0010559 GO:0034505 biolink:BiologicalProcess tooth mineralization The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. go.json tooth calcification http://purl.obolibrary.org/obo/GO_0034505 GO:0010556 biolink:BiologicalProcess regulation of macromolecule biosynthetic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json http://purl.obolibrary.org/obo/GO_0010556 GO:0010557 biolink:BiologicalProcess positive regulation of macromolecule biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json http://purl.obolibrary.org/obo/GO_0010557 GO:0034506 biolink:CellularComponent chromosome, centromeric core domain The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it. go.json chromosome, centric core region|chromosome, centromeric core region http://purl.obolibrary.org/obo/GO_0034506 GO:0034507 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034507 GO:0034508 biolink:BiologicalProcess centromere complex assembly The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. go.json centromere assembly|centromere organization|chromosome, centromeric region assembly http://purl.obolibrary.org/obo/GO_0034508 GO:0009570 biolink:CellularComponent chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0009570 GO:0034509 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034509 GO:0009571 biolink:CellularComponent proplastid stroma The space enclosed by the double membrane of a proplastid. go.json http://purl.obolibrary.org/obo/GO_0009571 GO:0010550 biolink:BiologicalProcess regulation of PSII associated light-harvesting complex II catabolic process Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II. go.json regulation of LHCII catabolism|regulation of LHCII degradation http://purl.obolibrary.org/obo/GO_0010550 GO:0009561 biolink:BiologicalProcess megagametogenesis The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. Wikipedia:Megagametogenesis go.json embryo sac development from the megaspore|megagametophyte nucleus division http://purl.obolibrary.org/obo/GO_0009561 GO:0010551 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010551 GO:0009562 biolink:BiologicalProcess embryo sac nuclear migration The directed movement of an embryo sac nucleus to the pole or center of the cell. go.json embryo sac nucleus migration|female gametophyte nuclear migration|female gametophyte nucleus migration|megagametophyte nuclear migration|megagametophyte nucleus migration http://purl.obolibrary.org/obo/GO_0009562 GO:0009563 biolink:BiologicalProcess synergid differentiation The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell. go.json synergid cell differentiation http://purl.obolibrary.org/obo/GO_0009563 GO:0009564 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009564 GO:0009565 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009565 GO:0010554 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010554 GO:0009566 biolink:BiologicalProcess fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). Wikipedia:Fertilisation go.json syngamy http://purl.obolibrary.org/obo/GO_0009566 GO:0010555 biolink:BiologicalProcess response to mannitol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus. go.json response to mannitol stimulus http://purl.obolibrary.org/obo/GO_0010555 GO:0034500 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034500 GO:0009567 biolink:BiologicalProcess double fertilization forming a zygote and endosperm Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana. go.json double fertilization http://purl.obolibrary.org/obo/GO_0009567 GO:0010552 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010552 GO:0034501 biolink:BiologicalProcess protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore. go.json condensin localization to kinetochore|protein localisation to kinetochore http://purl.obolibrary.org/obo/GO_0034501 GO:0010553 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010553 GO:0034502 biolink:BiologicalProcess protein localization to chromosome Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. go.json condensin localization to chromosome|protein localisation to chromosome http://purl.obolibrary.org/obo/GO_0034502 GO:0009568 biolink:CellularComponent amyloplast starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. go.json amyloplast starch granule http://purl.obolibrary.org/obo/GO_0009568 GO:0009569 biolink:CellularComponent chloroplast starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. go.json chloroplast starch granule http://purl.obolibrary.org/obo/GO_0009569 GO:0034495 biolink:CellularComponent protein storage vacuole lumen The volume enclosed by the protein storage vacuole membrane. go.json http://purl.obolibrary.org/obo/GO_0034495 GO:0034496 biolink:BiologicalProcess multivesicular body membrane disassembly The controlled breakdown of the membranes of multivesicular bodies. go.json MVB membrane disassembly http://purl.obolibrary.org/obo/GO_0034496 GO:0034497 biolink:BiologicalProcess protein localization to phagophore assembly site Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). go.json protein localisation to phagophore assembly site|protein localization to PAS|protein localization to pre-autophagosomal structure http://purl.obolibrary.org/obo/GO_0034497 GO:0034498 biolink:BiologicalProcess early endosome to Golgi transport The directed movement of substances from early endosomes to the Golgi. go.json PGE to Golgi transport|post-Golgi endosome to Golgi transport http://purl.obolibrary.org/obo/GO_0034498 GO:0034499 biolink:BiologicalProcess late endosome to Golgi transport The directed movement of substances from late endosomes to the Golgi. go.json PVE to Golgi transport|prevacuolar endosome to Golgi transport http://purl.obolibrary.org/obo/GO_0034499 GO:0034490 biolink:BiologicalProcess basic amino acid transmembrane import into vacuole The directed movement of basic amino acids into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0034490 GO:0034491 biolink:BiologicalProcess neutral amino acid transmembrane import into vacuole The directed movement of neutral amino acids into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0034491 GO:0034492 biolink:CellularComponent hydrogenosome lumen The volume enclosed by the hydrogenosome membrane. go.json http://purl.obolibrary.org/obo/GO_0034492 GO:0034493 biolink:CellularComponent melanosome lumen The volume enclosed by the melanosome membrane. go.json http://purl.obolibrary.org/obo/GO_0034493 GO:0034494 biolink:CellularComponent microneme lumen The volume enclosed by the microneme membrane. go.json http://purl.obolibrary.org/obo/GO_0034494 GO:0034484 biolink:BiologicalProcess raffinose catabolic process The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json raffinose breakdown|raffinose catabolism|raffinose degradation http://purl.obolibrary.org/obo/GO_0034484 GO:0034485 biolink:MolecularActivity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate. EC:3.1.3.86|MetaCyc:RXN-10036|RHEA:25528|Reactome:R-HSA-1675949 go.json http://purl.obolibrary.org/obo/GO_0034485 GO:0034486 biolink:BiologicalProcess vacuolar transmembrane transport The process in which a solute is transported from one side of the vacuolar membrane to the other. go.json vacuolar membrane transport http://purl.obolibrary.org/obo/GO_0034486 GO:0034487 biolink:BiologicalProcess vacuolar amino acid transmembrane transport The process in which an amino acid is transported from one side of the vacuolar membrane to the other. go.json vacuolar amino acid membrane transport http://purl.obolibrary.org/obo/GO_0034487 GO:0034488 biolink:BiologicalProcess basic amino acid transmembrane export from vacuole The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0034488 GO:0034489 biolink:BiologicalProcess neutral amino acid transmembrane export from vacuole The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0034489 GO:0034480 biolink:MolecularActivity phosphatidylcholine phospholipase C activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine. EC:3.1.4.3|MetaCyc:PHOSPHOLIPASE-C-RXN|RHEA:10604|Reactome:R-HSA-9680388 go.json Clostridium oedematiens beta- and gamma-toxins activity|Clostridium welchii alpha-toxin activity|heat-labile hemolysin|lipophosphodiesterase I activity|phosphatidylcholine cholinephosphohydrolase activity|phospholipase C, acting on phosphatidylcholine http://purl.obolibrary.org/obo/GO_0034480 GO:0034481 biolink:MolecularActivity chondroitin sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. go.json http://purl.obolibrary.org/obo/GO_0034481 GO:0034482 biolink:MolecularActivity chondroitin 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues. go.json chondroitin 2-O-sulphotransferase activity|chondroitin 2-sulfotransferase activity http://purl.obolibrary.org/obo/GO_0034482 GO:0034483 biolink:MolecularActivity heparan sulfate sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. go.json http://purl.obolibrary.org/obo/GO_0034483 GO:0034473 biolink:BiologicalProcess U1 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U1 snRNA molecule. go.json U1 snRNA 3' end processing http://purl.obolibrary.org/obo/GO_0034473 GO:0034474 biolink:BiologicalProcess U2 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U2 snRNA molecule. go.json U2 snRNA 3' end processing http://purl.obolibrary.org/obo/GO_0034474 GO:0034475 biolink:BiologicalProcess U4 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U4 snRNA molecule. go.json U4 snRNA 3' end processing http://purl.obolibrary.org/obo/GO_0034475 GO:0034476 biolink:BiologicalProcess U5 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U5 snRNA molecule. go.json U5 snRNA 3' end processing http://purl.obolibrary.org/obo/GO_0034476 GO:0034477 biolink:BiologicalProcess U6 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U6 snRNA molecule. go.json U6 snRNA 3' end processing http://purl.obolibrary.org/obo/GO_0034477 GO:0034478 biolink:BiologicalProcess phosphatidylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. go.json phosphatidylglycerol breakdown|phosphatidylglycerol catabolism|phosphatidylglycerol degradation http://purl.obolibrary.org/obo/GO_0034478 GO:0034479 biolink:MolecularActivity phosphatidylglycerol phospholipase C activity Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate. go.json http://purl.obolibrary.org/obo/GO_0034479 GO:0034470 biolink:BiologicalProcess ncRNA processing Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. go.json double-stranded RNA fragmentation|dsRNA fragmentation|dsRNA processing http://purl.obolibrary.org/obo/GO_0034470 GO:0034471 biolink:BiologicalProcess ncRNA 5'-end processing Any process involved in forming the mature 5' end of a non-coding RNA molecule. go.json ncRNA 5' end processing http://purl.obolibrary.org/obo/GO_0034471 GO:0034472 biolink:BiologicalProcess snRNA 3'-end processing Any process involved in forming the mature 3' end of an snRNA molecule. go.json snRNA 3' end processing http://purl.obolibrary.org/obo/GO_0034472 GO:0034462 biolink:BiologicalProcess small-subunit processome assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. go.json SSU processome assembly|small subunit processome assembly http://purl.obolibrary.org/obo/GO_0034462 GO:0034463 biolink:BiologicalProcess 90S preribosome assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions. go.json http://purl.obolibrary.org/obo/GO_0034463 GO:0034464 biolink:CellularComponent BBSome A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B. go.json Bardet-Biedl syndrome complex http://purl.obolibrary.org/obo/GO_0034464 GO:0034465 biolink:BiologicalProcess response to carbon monoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus. go.json http://purl.obolibrary.org/obo/GO_0034465 GO:0034466 biolink:CellularComponent chromaffin granule lumen The volume enclosed by the membrane of a chromaffin granule. go.json http://purl.obolibrary.org/obo/GO_0034466 GO:0034467 biolink:CellularComponent esterosome lumen The volume enclosed by the membrane of an esterosome. go.json http://purl.obolibrary.org/obo/GO_0034467 GO:0034468 biolink:CellularComponent glycosome lumen The volume enclosed by the membrane of a glycosome. go.json http://purl.obolibrary.org/obo/GO_0034468 GO:0034469 biolink:CellularComponent Golgi stack lumen The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex. go.json http://purl.obolibrary.org/obo/GO_0034469 GO:0034460 biolink:BiologicalProcess uropod assembly The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane. go.json uropod formation http://purl.obolibrary.org/obo/GO_0034460 GO:0034461 biolink:BiologicalProcess uropod retraction The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell. go.json http://purl.obolibrary.org/obo/GO_0034461 GO:1902939 biolink:BiologicalProcess negative regulation of intracellular calcium activated chloride channel activity Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity. go.json down regulation of intracellular calcium activated chloride channel activity|down-regulation of intracellular calcium activated chloride channel activity|downregulation of intracellular calcium activated chloride channel activity|inhibition of intracellular calcium activated chloride channel activity http://purl.obolibrary.org/obo/GO_1902939 gocheck_do_not_annotate GO:1902937 biolink:CellularComponent inward rectifier potassium channel complex A protein complex which is capable of inward rectifier potassium channel activity. go.json http://purl.obolibrary.org/obo/GO_1902937 GO:1902938 biolink:BiologicalProcess regulation of intracellular calcium activated chloride channel activity Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity. go.json http://purl.obolibrary.org/obo/GO_1902938 gocheck_do_not_annotate GO:1902935 biolink:BiologicalProcess protein localization to septin ring A process in which a protein is transported to, or maintained in, a location within a septin ring. go.json protein localisation in septin ring|protein localisation to septin ring|protein localization in septin ring http://purl.obolibrary.org/obo/GO_1902935 GO:1902936 biolink:MolecularActivity phosphatidylinositol bisphosphate binding Binding to phosphatidylinositol bisphosphate. go.json http://purl.obolibrary.org/obo/GO_1902936 GO:1902933 biolink:BiologicalProcess isopentenol metabolic process The chemical reactions and pathways involving isopentenol. go.json isopentenol metabolism http://purl.obolibrary.org/obo/GO_1902933 GO:1902934 biolink:BiologicalProcess isopentenol biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenol. go.json isopentenol anabolism|isopentenol biosynthesis|isopentenol formation|isopentenol synthesis http://purl.obolibrary.org/obo/GO_1902934 GO:1902931 biolink:BiologicalProcess negative regulation of alcohol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. go.json down regulation of alcohol anabolism|down regulation of alcohol biosynthesis|down regulation of alcohol biosynthetic process|down regulation of alcohol formation|down regulation of alcohol synthesis|down-regulation of alcohol anabolism|down-regulation of alcohol biosynthesis|down-regulation of alcohol biosynthetic process|down-regulation of alcohol formation|down-regulation of alcohol synthesis|downregulation of alcohol anabolism|downregulation of alcohol biosynthesis|downregulation of alcohol biosynthetic process|downregulation of alcohol formation|downregulation of alcohol synthesis|inhibition of alcohol anabolism|inhibition of alcohol biosynthesis|inhibition of alcohol biosynthetic process|inhibition of alcohol formation|inhibition of alcohol synthesis|negative regulation of alcohol anabolism|negative regulation of alcohol biosynthesis|negative regulation of alcohol formation|negative regulation of alcohol synthesis|negative regulation of solventogenesis http://purl.obolibrary.org/obo/GO_1902931 GO:1902932 biolink:BiologicalProcess positive regulation of alcohol biosynthetic process Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. go.json activation of alcohol anabolism|activation of alcohol biosynthesis|activation of alcohol biosynthetic process|activation of alcohol formation|activation of alcohol synthesis|positive regulation of alcohol anabolism|positive regulation of alcohol biosynthesis|positive regulation of alcohol formation|positive regulation of alcohol synthesis|positive regulation of solventogenesis|up regulation of alcohol anabolism|up regulation of alcohol biosynthesis|up regulation of alcohol biosynthetic process|up regulation of alcohol formation|up regulation of alcohol synthesis|up-regulation of alcohol anabolism|up-regulation of alcohol biosynthesis|up-regulation of alcohol biosynthetic process|up-regulation of alcohol formation|up-regulation of alcohol synthesis|upregulation of alcohol anabolism|upregulation of alcohol biosynthesis|upregulation of alcohol biosynthetic process|upregulation of alcohol formation|upregulation of alcohol synthesis http://purl.obolibrary.org/obo/GO_1902932 GO:1902930 biolink:BiologicalProcess regulation of alcohol biosynthetic process Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. go.json regulation of alcohol anabolism|regulation of alcohol biosynthesis|regulation of alcohol formation|regulation of alcohol synthesis|regulation of solventogenesis http://purl.obolibrary.org/obo/GO_1902930 GO:1902948 biolink:BiologicalProcess negative regulation of tau-protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity. go.json down regulation of CDK5/p23|down regulation of GSK|down regulation of STK31|down regulation of TPK|down regulation of TPK I|down regulation of TPK II|down regulation of TTK|down regulation of [Tau protein] kinase activity|down regulation of brain protein kinase PK40erk activity|down regulation of cdk5/p20|down regulation of glycogen synthase kinase-3beta activity|down regulation of protein tau kinase activity|down regulation of tau kinase activity|down regulation of tau protein kinase activity|down regulation of tau-protein kinase I activity|down regulation of tau-protein kinase II activity|down regulation of tau-protein kinase activity|down regulation of tau-tubulin kinase activity|down-regulation of CDK5/p23|down-regulation of GSK|down-regulation of STK31|down-regulation of TPK|down-regulation of TPK I|down-regulation of TPK II|down-regulation of TTK|down-regulation of [Tau protein] kinase activity|down-regulation of brain protein kinase PK40erk activity|down-regulation of cdk5/p20|down-regulation of glycogen synthase kinase-3beta activity|down-regulation of protein tau kinase activity|down-regulation of tau kinase activity|down-regulation of tau protein kinase activity|down-regulation of tau-protein kinase I activity|down-regulation of tau-protein kinase II activity|down-regulation of tau-protein kinase activity|down-regulation of tau-tubulin kinase activity|downregulation of CDK5/p23|downregulation of GSK|downregulation of STK31|downregulation of TPK|downregulation of TPK I|downregulation of TPK II|downregulation of TTK|downregulation of [Tau protein] kinase activity|downregulation of brain protein kinase PK40erk activity|downregulation of cdk5/p20|downregulation of glycogen synthase kinase-3beta activity|downregulation of protein tau kinase activity|downregulation of tau kinase activity|downregulation of tau protein kinase activity|downregulation of tau-protein kinase I activity|downregulation of tau-protein kinase II activity|downregulation of tau-protein kinase activity|downregulation of tau-tubulin kinase activity|inhibition of CDK5/p23|inhibition of GSK|inhibition of STK31|inhibition of TPK|inhibition of TPK I|inhibition of TPK II|inhibition of TTK|inhibition of [Tau protein] kinase activity|inhibition of brain protein kinase PK40erk activity|inhibition of cdk5/p20|inhibition of glycogen synthase kinase-3beta activity|inhibition of protein tau kinase activity|inhibition of tau kinase activity|inhibition of tau protein kinase activity|inhibition of tau-protein kinase I activity|inhibition of tau-protein kinase II activity|inhibition of tau-protein kinase activity|inhibition of tau-tubulin kinase activity|negative regulation of CDK5/p23|negative regulation of GSK|negative regulation of STK31|negative regulation of TPK|negative regulation of TPK I|negative regulation of TPK II|negative regulation of TTK|negative regulation of [Tau protein] kinase activity|negative regulation of brain protein kinase PK40erk activity|negative regulation of cdk5/p20|negative regulation of glycogen synthase kinase-3beta activity|negative regulation of protein tau kinase activity|negative regulation of tau kinase activity|negative regulation of tau protein kinase activity|negative regulation of tau-protein kinase I activity|negative regulation of tau-protein kinase II activity|negative regulation of tau-tubulin kinase activity http://purl.obolibrary.org/obo/GO_1902948 gocheck_do_not_annotate GO:1902949 biolink:BiologicalProcess positive regulation of tau-protein kinase activity Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity. go.json activation of CDK5/p23|activation of GSK|activation of STK31|activation of TPK|activation of TPK I|activation of TPK II|activation of TTK|activation of [Tau protein] kinase activity|activation of brain protein kinase PK40erk activity|activation of cdk5/p20|activation of glycogen synthase kinase-3beta activity|activation of protein tau kinase activity|activation of tau kinase activity|activation of tau protein kinase activity|activation of tau-protein kinase I activity|activation of tau-protein kinase II activity|activation of tau-protein kinase activity|activation of tau-tubulin kinase activity|positive regulation of CDK5/p23|positive regulation of GSK|positive regulation of STK31|positive regulation of TPK|positive regulation of TPK I|positive regulation of TPK II|positive regulation of TTK|positive regulation of [Tau protein] kinase activity|positive regulation of brain protein kinase PK40erk activity|positive regulation of cdk5/p20|positive regulation of glycogen synthase kinase-3beta activity|positive regulation of protein tau kinase activity|positive regulation of tau kinase activity|positive regulation of tau protein kinase activity|positive regulation of tau-protein kinase I activity|positive regulation of tau-protein kinase II activity|positive regulation of tau-tubulin kinase activity|up regulation of CDK5/p23|up regulation of GSK|up regulation of STK31|up regulation of TPK|up regulation of TPK I|up regulation of TPK II|up regulation of TTK|up regulation of [Tau protein] kinase activity|up regulation of brain protein kinase PK40erk activity|up regulation of cdk5/p20|up regulation of glycogen synthase kinase-3beta activity|up regulation of protein tau kinase activity|up regulation of tau kinase activity|up regulation of tau protein kinase activity|up regulation of tau-protein kinase I activity|up regulation of tau-protein kinase II activity|up regulation of tau-protein kinase activity|up regulation of tau-tubulin kinase activity|up-regulation of CDK5/p23|up-regulation of GSK|up-regulation of STK31|up-regulation of TPK|up-regulation of TPK I|up-regulation of TPK II|up-regulation of TTK|up-regulation of [Tau protein] kinase activity|up-regulation of brain protein kinase PK40erk activity|up-regulation of cdk5/p20|up-regulation of glycogen synthase kinase-3beta activity|up-regulation of protein tau kinase activity|up-regulation of tau kinase activity|up-regulation of tau protein kinase activity|up-regulation of tau-protein kinase I activity|up-regulation of tau-protein kinase II activity|up-regulation of tau-protein kinase activity|up-regulation of tau-tubulin kinase activity|upregulation of CDK5/p23|upregulation of GSK|upregulation of STK31|upregulation of TPK|upregulation of TPK I|upregulation of TPK II|upregulation of TTK|upregulation of [Tau protein] kinase activity|upregulation of brain protein kinase PK40erk activity|upregulation of cdk5/p20|upregulation of glycogen synthase kinase-3beta activity|upregulation of protein tau kinase activity|upregulation of tau kinase activity|upregulation of tau protein kinase activity|upregulation of tau-protein kinase I activity|upregulation of tau-protein kinase II activity|upregulation of tau-protein kinase activity|upregulation of tau-tubulin kinase activity http://purl.obolibrary.org/obo/GO_1902949 gocheck_do_not_annotate GO:1902946 biolink:BiologicalProcess protein localization to early endosome A process in which a protein is transported to, or maintained in, a location within an early endosome. go.json protein localisation in early endosome|protein localisation to early endosome|protein localization in early endosome http://purl.obolibrary.org/obo/GO_1902946 GO:1902947 biolink:BiologicalProcess regulation of tau-protein kinase activity Any process that modulates the frequency, rate or extent of tau-protein kinase activity. go.json regulation of ATP:tau-protein O-phosphotransferase activity|regulation of CDK5/p23|regulation of GSK|regulation of STK31|regulation of TPK|regulation of TPK I|regulation of TPK II|regulation of TTK|regulation of [Tau protein] kinase activity|regulation of brain protein kinase PK40erk activity|regulation of cdk5/p20|regulation of glycogen synthase kinase-3beta activity|regulation of protein tau kinase activity|regulation of tau kinase activity|regulation of tau protein kinase activity|regulation of tau-protein kinase I activity|regulation of tau-protein kinase II activity|regulation of tau-tubulin kinase activity http://purl.obolibrary.org/obo/GO_1902947 gocheck_do_not_annotate GO:1902944 biolink:MolecularActivity aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process. go.json aspartate protease activity involved in APP catabolic process|aspartate protease activity involved in APP catabolism|aspartate protease activity involved in amyloid precursor protein breakdown|aspartate protease activity involved in amyloid precursor protein catabolic process|aspartate protease activity involved in amyloid precursor protein catabolism|aspartate protease activity involved in amyloid precursor protein degradation|aspartic endopeptidase activity involved in APP catabolic process|aspartic endopeptidase activity involved in APP catabolism|aspartic endopeptidase activity involved in amyloid precursor protein breakdown|aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|aspartic endopeptidase activity involved in amyloid precursor protein catabolism|aspartic endopeptidase activity involved in amyloid precursor protein degradation|aspartic protease activity involved in APP catabolic process|aspartic protease activity involved in APP catabolism|aspartic protease activity involved in amyloid precursor protein breakdown|aspartic protease activity involved in amyloid precursor protein catabolic process|aspartic protease activity involved in amyloid precursor protein catabolism|aspartic protease activity involved in amyloid precursor protein degradation|aspartic-type endopeptidase activity involved in APP catabolic process|aspartic-type endopeptidase activity involved in APP catabolism|aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|aspartyl protease activity involved in APP catabolic process|aspartyl protease activity involved in APP catabolism|aspartyl protease activity involved in amyloid precursor protein breakdown|aspartyl protease activity involved in amyloid precursor protein catabolic process|aspartyl protease activity involved in amyloid precursor protein catabolism|aspartyl protease activity involved in amyloid precursor protein degradation|carboxyl protease activity involved in APP catabolic process|carboxyl protease activity involved in APP catabolism|carboxyl protease activity involved in amyloid precursor protein breakdown|carboxyl protease activity involved in amyloid precursor protein catabolic process|carboxyl protease activity involved in amyloid precursor protein catabolism|carboxyl protease activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902944 GO:1902945 biolink:MolecularActivity metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process. Reactome:R-HSA-9010034 go.json metalloendopeptidase activity involved in APP catabolic process|metalloendopeptidase activity involved in APP catabolism|metalloendopeptidase activity involved in amyloid precursor protein breakdown|metalloendopeptidase activity involved in amyloid precursor protein catabolism|metalloendopeptidase activity involved in amyloid precursor protein degradation|metalloendoprotease activity involved in APP catabolic process|metalloendoprotease activity involved in APP catabolism|metalloendoprotease activity involved in amyloid precursor protein breakdown|metalloendoprotease activity involved in amyloid precursor protein catabolic process|metalloendoprotease activity involved in amyloid precursor protein catabolism|metalloendoprotease activity involved in amyloid precursor protein degradation|metalloendoproteinase activity involved in APP catabolic process|metalloendoproteinase activity involved in APP catabolism|metalloendoproteinase activity involved in amyloid precursor protein breakdown|metalloendoproteinase activity involved in amyloid precursor protein catabolic process|metalloendoproteinase activity involved in amyloid precursor protein catabolism|metalloendoproteinase activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902945 GO:1902942 biolink:BiologicalProcess negative regulation of voltage-gated chloride channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity. go.json down regulation of voltage gated chloride channel activity|down regulation of voltage-dependent chloride channel activity|down regulation of voltage-gated chloride channel activity|down-regulation of voltage gated chloride channel activity|down-regulation of voltage-dependent chloride channel activity|down-regulation of voltage-gated chloride channel activity|downregulation of voltage gated chloride channel activity|downregulation of voltage-dependent chloride channel activity|downregulation of voltage-gated chloride channel activity|inhibition of voltage gated chloride channel activity|inhibition of voltage-dependent chloride channel activity|inhibition of voltage-gated chloride channel activity|negative regulation of voltage gated chloride channel activity|negative regulation of voltage-dependent chloride channel activity http://purl.obolibrary.org/obo/GO_1902942 gocheck_do_not_annotate GO:1902943 biolink:BiologicalProcess positive regulation of voltage-gated chloride channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity. go.json activation of voltage gated chloride channel activity|activation of voltage-dependent chloride channel activity|activation of voltage-gated chloride channel activity|positive regulation of voltage gated chloride channel activity|positive regulation of voltage-dependent chloride channel activity|up regulation of voltage gated chloride channel activity|up regulation of voltage-dependent chloride channel activity|up regulation of voltage-gated chloride channel activity|up-regulation of voltage gated chloride channel activity|up-regulation of voltage-dependent chloride channel activity|up-regulation of voltage-gated chloride channel activity|upregulation of voltage gated chloride channel activity|upregulation of voltage-dependent chloride channel activity|upregulation of voltage-gated chloride channel activity http://purl.obolibrary.org/obo/GO_1902943 gocheck_do_not_annotate GO:1902940 biolink:BiologicalProcess positive regulation of intracellular calcium activated chloride channel activity Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity. go.json activation of intracellular calcium activated chloride channel activity|up regulation of intracellular calcium activated chloride channel activity|up-regulation of intracellular calcium activated chloride channel activity|upregulation of intracellular calcium activated chloride channel activity http://purl.obolibrary.org/obo/GO_1902940 gocheck_do_not_annotate GO:1902941 biolink:BiologicalProcess regulation of voltage-gated chloride channel activity Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity. go.json regulation of voltage gated chloride channel activity|regulation of voltage-dependent chloride channel activity http://purl.obolibrary.org/obo/GO_1902941 gocheck_do_not_annotate GO:1902959 biolink:BiologicalProcess regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. go.json regulation of aspartate protease activity involved in APP catabolic process|regulation of aspartate protease activity involved in APP catabolism|regulation of aspartate protease activity involved in amyloid precursor protein breakdown|regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|regulation of aspartate protease activity involved in amyloid precursor protein catabolism|regulation of aspartate protease activity involved in amyloid precursor protein degradation|regulation of aspartic endopeptidase activity involved in APP catabolic process|regulation of aspartic endopeptidase activity involved in APP catabolism|regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|regulation of aspartic protease activity involved in APP catabolic process|regulation of aspartic protease activity involved in APP catabolism|regulation of aspartic protease activity involved in amyloid precursor protein breakdown|regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|regulation of aspartic protease activity involved in amyloid precursor protein catabolism|regulation of aspartic protease activity involved in amyloid precursor protein degradation|regulation of aspartic-type endopeptidase activity involved in APP catabolic process|regulation of aspartic-type endopeptidase activity involved in APP catabolism|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|regulation of aspartyl protease activity involved in APP catabolic process|regulation of aspartyl protease activity involved in APP catabolism|regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|regulation of aspartyl protease activity involved in amyloid precursor protein degradation|regulation of carboxyl protease activity involved in APP catabolic process|regulation of carboxyl protease activity involved in APP catabolism|regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|regulation of carboxyl protease activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902959 gocheck_do_not_annotate GO:1902957 biolink:BiologicalProcess negative regulation of mitochondrial electron transport, NADH to ubiquinone Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. go.json down regulation of complex I (NADH to ubiquinone)|down regulation of mitochondrial electron transport, NADH to ubiquinone|down regulation of oxidative phosphorylation, NADH to ubiquinone|down-regulation of complex I (NADH to ubiquinone)|down-regulation of mitochondrial electron transport, NADH to ubiquinone|down-regulation of oxidative phosphorylation, NADH to ubiquinone|downregulation of complex I (NADH to ubiquinone)|downregulation of mitochondrial electron transport, NADH to ubiquinone|downregulation of oxidative phosphorylation, NADH to ubiquinone|inhibition of complex I (NADH to ubiquinone)|inhibition of mitochondrial electron transport, NADH to ubiquinone|inhibition of oxidative phosphorylation, NADH to ubiquinone|negative regulation of complex I (NADH to ubiquinone)|negative regulation of oxidative phosphorylation, NADH to ubiquinone http://purl.obolibrary.org/obo/GO_1902957 GO:1902958 biolink:BiologicalProcess positive regulation of mitochondrial electron transport, NADH to ubiquinone Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. go.json activation of complex I (NADH to ubiquinone)|activation of mitochondrial electron transport, NADH to ubiquinone|activation of oxidative phosphorylation, NADH to ubiquinone|positive regulation of complex I (NADH to ubiquinone)|positive regulation of oxidative phosphorylation, NADH to ubiquinone|up regulation of complex I (NADH to ubiquinone)|up regulation of mitochondrial electron transport, NADH to ubiquinone|up regulation of oxidative phosphorylation, NADH to ubiquinone|up-regulation of complex I (NADH to ubiquinone)|up-regulation of mitochondrial electron transport, NADH to ubiquinone|up-regulation of oxidative phosphorylation, NADH to ubiquinone|upregulation of complex I (NADH to ubiquinone)|upregulation of mitochondrial electron transport, NADH to ubiquinone|upregulation of oxidative phosphorylation, NADH to ubiquinone http://purl.obolibrary.org/obo/GO_1902958 GO:1902955 biolink:BiologicalProcess positive regulation of early endosome to recycling endosome transport Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport. go.json activation of early endosome to recycling endosome transport|up regulation of early endosome to recycling endosome transport|up-regulation of early endosome to recycling endosome transport|upregulation of early endosome to recycling endosome transport http://purl.obolibrary.org/obo/GO_1902955 GO:1902956 biolink:BiologicalProcess regulation of mitochondrial electron transport, NADH to ubiquinone Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. go.json regulation of complex I (NADH to ubiquinone)|regulation of oxidative phosphorylation, NADH to ubiquinone http://purl.obolibrary.org/obo/GO_1902956 GO:1902953 biolink:BiologicalProcess positive regulation of ER to Golgi vesicle-mediated transport Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport. go.json activation of ER to Golgi transport|activation of ER to Golgi vesicle-mediated transport|activation of endoplasmic reticulum to Golgi transport|activation of endoplasmic reticulum to Golgi vesicle-mediated transport|activation of rough ER to cis-Golgi transport|activation of rough ER to cis-Golgi vesicle-mediated transport|activation of rough endoplasmic reticulum to cis-Golgi transport|activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|positive regulation of ER to Golgi transport|positive regulation of endoplasmic reticulum to Golgi transport|positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport|positive regulation of rough ER to cis-Golgi transport|positive regulation of rough ER to cis-Golgi vesicle-mediated transport|positive regulation of rough endoplasmic reticulum to cis-Golgi transport|positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|up regulation of ER to Golgi transport|up regulation of ER to Golgi vesicle-mediated transport|up regulation of endoplasmic reticulum to Golgi transport|up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport|up regulation of rough ER to cis-Golgi transport|up regulation of rough ER to cis-Golgi vesicle-mediated transport|up regulation of rough endoplasmic reticulum to cis-Golgi transport|up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|up-regulation of ER to Golgi transport|up-regulation of ER to Golgi vesicle-mediated transport|up-regulation of endoplasmic reticulum to Golgi transport|up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport|up-regulation of rough ER to cis-Golgi transport|up-regulation of rough ER to cis-Golgi vesicle-mediated transport|up-regulation of rough endoplasmic reticulum to cis-Golgi transport|up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|upregulation of ER to Golgi transport|upregulation of ER to Golgi vesicle-mediated transport|upregulation of endoplasmic reticulum to Golgi transport|upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport|upregulation of rough ER to cis-Golgi transport|upregulation of rough ER to cis-Golgi vesicle-mediated transport|upregulation of rough endoplasmic reticulum to cis-Golgi transport|upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport http://purl.obolibrary.org/obo/GO_1902953 GO:1902954 biolink:BiologicalProcess regulation of early endosome to recycling endosome transport Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport. go.json http://purl.obolibrary.org/obo/GO_1902954 GO:1902951 biolink:BiologicalProcess negative regulation of dendritic spine maintenance Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance. go.json down regulation of dendritic spine maintenance|down-regulation of dendritic spine maintenance|downregulation of dendritic spine maintenance|inhibition of dendritic spine maintenance http://purl.obolibrary.org/obo/GO_1902951 GO:1902952 biolink:BiologicalProcess positive regulation of dendritic spine maintenance Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance. go.json activation of dendritic spine maintenance|up regulation of dendritic spine maintenance|up-regulation of dendritic spine maintenance|upregulation of dendritic spine maintenance http://purl.obolibrary.org/obo/GO_1902952 GO:1902950 biolink:BiologicalProcess regulation of dendritic spine maintenance Any process that modulates the frequency, rate or extent of dendritic spine maintenance. go.json http://purl.obolibrary.org/obo/GO_1902950 GO:1902968 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1902968 GO:1902969 biolink:BiologicalProcess mitotic DNA replication Any nuclear DNA replication that is involved in a mitotic cell cycle. go.json DNA replication during S phase involved in mitotic cell cycle|DNA replication involved in S phase involved in mitotic cell cycle|DNA replication involved in S-phase involved in mitotic cell cycle|mitotic cell cycle DNA replication|mitotic nuclear cell cycle DNA replication|nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1902969 GO:1902966 biolink:BiologicalProcess positive regulation of protein localization to early endosome Any process that activates or increases the frequency, rate or extent of protein localization to early endosome. go.json activation of protein localisation in early endosome|activation of protein localisation to early endosome|activation of protein localization in early endosome|activation of protein localization to early endosome|positive regulation of protein localisation in early endosome|positive regulation of protein localisation to early endosome|positive regulation of protein localization in early endosome|up regulation of protein localisation in early endosome|up regulation of protein localisation to early endosome|up regulation of protein localization in early endosome|up regulation of protein localization to early endosome|up-regulation of protein localisation in early endosome|up-regulation of protein localisation to early endosome|up-regulation of protein localization in early endosome|up-regulation of protein localization to early endosome|upregulation of protein localisation in early endosome|upregulation of protein localisation to early endosome|upregulation of protein localization in early endosome|upregulation of protein localization to early endosome http://purl.obolibrary.org/obo/GO_1902966 GO:1902967 biolink:BiologicalProcess protein localization to mitotic spindle midzone A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone. go.json protein localisation in mitotic spindle midzone|protein localisation to mitotic spindle midzone|protein localization in mitotic spindle midzone http://purl.obolibrary.org/obo/GO_1902967 GO:1902964 biolink:BiologicalProcess positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. go.json activation of metalloendopeptidase activity involved in APP catabolic process|activation of metalloendopeptidase activity involved in APP catabolism|activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|activation of metalloendopeptidase activity involved in amyloid precursor protein degradation|activation of metalloendoprotease activity involved in APP catabolic process|activation of metalloendoprotease activity involved in APP catabolism|activation of metalloendoprotease activity involved in amyloid precursor protein breakdown|activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|activation of metalloendoprotease activity involved in amyloid precursor protein catabolism|activation of metalloendoprotease activity involved in amyloid precursor protein degradation|activation of metalloendoproteinase activity involved in APP catabolic process|activation of metalloendoproteinase activity involved in APP catabolism|activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|activation of metalloendoproteinase activity involved in amyloid precursor protein degradation|positive regulation of metalloendopeptidase activity involved in APP catabolic process|positive regulation of metalloendopeptidase activity involved in APP catabolism|positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|positive regulation of metalloendoprotease activity involved in APP catabolic process|positive regulation of metalloendoprotease activity involved in APP catabolism|positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|positive regulation of metalloendoproteinase activity involved in APP catabolic process|positive regulation of metalloendoproteinase activity involved in APP catabolism|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|up regulation of metalloendopeptidase activity involved in APP catabolic process|up regulation of metalloendopeptidase activity involved in APP catabolism|up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|up regulation of metalloendoprotease activity involved in APP catabolic process|up regulation of metalloendoprotease activity involved in APP catabolism|up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|up regulation of metalloendoproteinase activity involved in APP catabolic process|up regulation of metalloendoproteinase activity involved in APP catabolism|up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|up-regulation of metalloendopeptidase activity involved in APP catabolic process|up-regulation of metalloendopeptidase activity involved in APP catabolism|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|up-regulation of metalloendoprotease activity involved in APP catabolic process|up-regulation of metalloendoprotease activity involved in APP catabolism|up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|up-regulation of metalloendoproteinase activity involved in APP catabolic process|up-regulation of metalloendoproteinase activity involved in APP catabolism|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|upregulation of metalloendopeptidase activity involved in APP catabolic process|upregulation of metalloendopeptidase activity involved in APP catabolism|upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|upregulation of metalloendoprotease activity involved in APP catabolic process|upregulation of metalloendoprotease activity involved in APP catabolism|upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation|upregulation of metalloendoproteinase activity involved in APP catabolic process|upregulation of metalloendoproteinase activity involved in APP catabolism|upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902964 gocheck_do_not_annotate GO:1902965 biolink:BiologicalProcess regulation of protein localization to early endosome Any process that modulates the frequency, rate or extent of protein localization to early endosome. go.json regulation of protein localisation in early endosome|regulation of protein localisation to early endosome|regulation of protein localization in early endosome http://purl.obolibrary.org/obo/GO_1902965 GO:1902962 biolink:BiologicalProcess regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. go.json regulation of metalloendopeptidase activity involved in APP catabolic process|regulation of metalloendopeptidase activity involved in APP catabolism|regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|regulation of metalloendoprotease activity involved in APP catabolic process|regulation of metalloendoprotease activity involved in APP catabolism|regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|regulation of metalloendoproteinase activity involved in APP catabolic process|regulation of metalloendoproteinase activity involved in APP catabolism|regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902962 gocheck_do_not_annotate GO:1902963 biolink:BiologicalProcess negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. go.json down regulation of metalloendopeptidase activity involved in APP catabolic process|down regulation of metalloendopeptidase activity involved in APP catabolism|down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down regulation of metalloendoprotease activity involved in APP catabolic process|down regulation of metalloendoprotease activity involved in APP catabolism|down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|down regulation of metalloendoproteinase activity involved in APP catabolic process|down regulation of metalloendoproteinase activity involved in APP catabolism|down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|down-regulation of metalloendopeptidase activity involved in APP catabolic process|down-regulation of metalloendopeptidase activity involved in APP catabolism|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down-regulation of metalloendoprotease activity involved in APP catabolic process|down-regulation of metalloendoprotease activity involved in APP catabolism|down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|down-regulation of metalloendoproteinase activity involved in APP catabolic process|down-regulation of metalloendoproteinase activity involved in APP catabolism|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|downregulation of metalloendopeptidase activity involved in APP catabolic process|downregulation of metalloendopeptidase activity involved in APP catabolism|downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|downregulation of metalloendoprotease activity involved in APP catabolic process|downregulation of metalloendoprotease activity involved in APP catabolism|downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation|downregulation of metalloendoproteinase activity involved in APP catabolic process|downregulation of metalloendoproteinase activity involved in APP catabolism|downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|inhibition of metalloendopeptidase activity involved in APP catabolic process|inhibition of metalloendopeptidase activity involved in APP catabolism|inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown|inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism|inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation|inhibition of metalloendoprotease activity involved in APP catabolic process|inhibition of metalloendoprotease activity involved in APP catabolism|inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown|inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism|inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation|inhibition of metalloendoproteinase activity involved in APP catabolic process|inhibition of metalloendoproteinase activity involved in APP catabolism|inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown|inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism|inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation|negative regulation of metalloendopeptidase activity involved in APP catabolic process|negative regulation of metalloendopeptidase activity involved in APP catabolism|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|negative regulation of metalloendoprotease activity involved in APP catabolic process|negative regulation of metalloendoprotease activity involved in APP catabolism|negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|negative regulation of metalloendoproteinase activity involved in APP catabolic process|negative regulation of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902963 gocheck_do_not_annotate GO:1902960 biolink:BiologicalProcess negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. go.json down regulation of aspartate protease activity involved in APP catabolic process|down regulation of aspartate protease activity involved in APP catabolism|down regulation of aspartate protease activity involved in amyloid precursor protein breakdown|down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartate protease activity involved in amyloid precursor protein catabolism|down regulation of aspartate protease activity involved in amyloid precursor protein degradation|down regulation of aspartic endopeptidase activity involved in APP catabolic process|down regulation of aspartic endopeptidase activity involved in APP catabolism|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|down regulation of aspartic protease activity involved in APP catabolic process|down regulation of aspartic protease activity involved in APP catabolism|down regulation of aspartic protease activity involved in amyloid precursor protein breakdown|down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartic protease activity involved in amyloid precursor protein catabolism|down regulation of aspartic protease activity involved in amyloid precursor protein degradation|down regulation of aspartic-type endopeptidase activity involved in APP catabolic process|down regulation of aspartic-type endopeptidase activity involved in APP catabolism|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|down regulation of aspartyl protease activity involved in APP catabolic process|down regulation of aspartyl protease activity involved in APP catabolism|down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|down regulation of aspartyl protease activity involved in amyloid precursor protein degradation|down regulation of carboxyl protease activity involved in APP catabolic process|down regulation of carboxyl protease activity involved in APP catabolism|down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|down regulation of carboxyl protease activity involved in amyloid precursor protein degradation|down-regulation of aspartate protease activity involved in APP catabolic process|down-regulation of aspartate protease activity involved in APP catabolism|down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown|down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartate protease activity involved in amyloid precursor protein degradation|down-regulation of aspartic endopeptidase activity involved in APP catabolic process|down-regulation of aspartic endopeptidase activity involved in APP catabolism|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|down-regulation of aspartic protease activity involved in APP catabolic process|down-regulation of aspartic protease activity involved in APP catabolism|down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown|down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartic protease activity involved in amyloid precursor protein degradation|down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process|down-regulation of aspartic-type endopeptidase activity involved in APP catabolism|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|down-regulation of aspartyl protease activity involved in APP catabolic process|down-regulation of aspartyl protease activity involved in APP catabolism|down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation|down-regulation of carboxyl protease activity involved in APP catabolic process|down-regulation of carboxyl protease activity involved in APP catabolism|down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation|downregulation of aspartate protease activity involved in APP catabolic process|downregulation of aspartate protease activity involved in APP catabolism|downregulation of aspartate protease activity involved in amyloid precursor protein breakdown|downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process|downregulation of aspartate protease activity involved in amyloid precursor protein catabolism|downregulation of aspartate protease activity involved in amyloid precursor protein degradation|downregulation of aspartic endopeptidase activity involved in APP catabolic process|downregulation of aspartic endopeptidase activity involved in APP catabolism|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|downregulation of aspartic protease activity involved in APP catabolic process|downregulation of aspartic protease activity involved in APP catabolism|downregulation of aspartic protease activity involved in amyloid precursor protein breakdown|downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process|downregulation of aspartic protease activity involved in amyloid precursor protein catabolism|downregulation of aspartic protease activity involved in amyloid precursor protein degradation|downregulation of aspartic-type endopeptidase activity involved in APP catabolic process|downregulation of aspartic-type endopeptidase activity involved in APP catabolism|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|downregulation of aspartyl protease activity involved in APP catabolic process|downregulation of aspartyl protease activity involved in APP catabolism|downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown|downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism|downregulation of aspartyl protease activity involved in amyloid precursor protein degradation|downregulation of carboxyl protease activity involved in APP catabolic process|downregulation of carboxyl protease activity involved in APP catabolism|downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown|downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism|downregulation of carboxyl protease activity involved in amyloid precursor protein degradation|inhibition of aspartate protease activity involved in APP catabolic process|inhibition of aspartate protease activity involved in APP catabolism|inhibition of aspartate protease activity involved in amyloid precursor protein breakdown|inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartate protease activity involved in amyloid precursor protein catabolism|inhibition of aspartate protease activity involved in amyloid precursor protein degradation|inhibition of aspartic endopeptidase activity involved in APP catabolic process|inhibition of aspartic endopeptidase activity involved in APP catabolism|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation|inhibition of aspartic protease activity involved in APP catabolic process|inhibition of aspartic protease activity involved in APP catabolism|inhibition of aspartic protease activity involved in amyloid precursor protein breakdown|inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartic protease activity involved in amyloid precursor protein catabolism|inhibition of aspartic protease activity involved in amyloid precursor protein degradation|inhibition of aspartic-type endopeptidase activity involved in APP catabolic process|inhibition of aspartic-type endopeptidase activity involved in APP catabolism|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|inhibition of aspartyl protease activity involved in APP catabolic process|inhibition of aspartyl protease activity involved in APP catabolism|inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown|inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism|inhibition of aspartyl protease activity involved in amyloid precursor protein degradation|inhibition of carboxyl protease activity involved in APP catabolic process|inhibition of carboxyl protease activity involved in APP catabolism|inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown|inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process|inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism|inhibition of carboxyl protease activity involved in amyloid precursor protein degradation|negative regulation of aspartate protease activity involved in APP catabolic process|negative regulation of aspartate protease activity involved in APP catabolism|negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartate protease activity involved in amyloid precursor protein degradation|negative regulation of aspartic endopeptidase activity involved in APP catabolic process|negative regulation of aspartic endopeptidase activity involved in APP catabolism|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|negative regulation of aspartic protease activity involved in APP catabolic process|negative regulation of aspartic protease activity involved in APP catabolism|negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartic protease activity involved in amyloid precursor protein degradation|negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process|negative regulation of aspartic-type endopeptidase activity involved in APP catabolism|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|negative regulation of aspartyl protease activity involved in APP catabolic process|negative regulation of aspartyl protease activity involved in APP catabolism|negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation|negative regulation of carboxyl protease activity involved in APP catabolic process|negative regulation of carboxyl protease activity involved in APP catabolism|negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902960 gocheck_do_not_annotate GO:1902961 biolink:BiologicalProcess positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. go.json activation of aspartate protease activity involved in APP catabolic process|activation of aspartate protease activity involved in APP catabolism|activation of aspartate protease activity involved in amyloid precursor protein breakdown|activation of aspartate protease activity involved in amyloid precursor protein catabolic process|activation of aspartate protease activity involved in amyloid precursor protein catabolism|activation of aspartate protease activity involved in amyloid precursor protein degradation|activation of aspartic endopeptidase activity involved in APP catabolic process|activation of aspartic endopeptidase activity involved in APP catabolism|activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|activation of aspartic protease activity involved in APP catabolic process|activation of aspartic protease activity involved in APP catabolism|activation of aspartic protease activity involved in amyloid precursor protein breakdown|activation of aspartic protease activity involved in amyloid precursor protein catabolic process|activation of aspartic protease activity involved in amyloid precursor protein catabolism|activation of aspartic protease activity involved in amyloid precursor protein degradation|activation of aspartic-type endopeptidase activity involved in APP catabolic process|activation of aspartic-type endopeptidase activity involved in APP catabolism|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|activation of aspartyl protease activity involved in APP catabolic process|activation of aspartyl protease activity involved in APP catabolism|activation of aspartyl protease activity involved in amyloid precursor protein breakdown|activation of aspartyl protease activity involved in amyloid precursor protein catabolic process|activation of aspartyl protease activity involved in amyloid precursor protein catabolism|activation of aspartyl protease activity involved in amyloid precursor protein degradation|activation of carboxyl protease activity involved in APP catabolic process|activation of carboxyl protease activity involved in APP catabolism|activation of carboxyl protease activity involved in amyloid precursor protein breakdown|activation of carboxyl protease activity involved in amyloid precursor protein catabolic process|activation of carboxyl protease activity involved in amyloid precursor protein catabolism|activation of carboxyl protease activity involved in amyloid precursor protein degradation|positive regulation of aspartate protease activity involved in APP catabolic process|positive regulation of aspartate protease activity involved in APP catabolism|positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown|positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartate protease activity involved in amyloid precursor protein degradation|positive regulation of aspartic endopeptidase activity involved in APP catabolic process|positive regulation of aspartic endopeptidase activity involved in APP catabolism|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of aspartic protease activity involved in APP catabolic process|positive regulation of aspartic protease activity involved in APP catabolism|positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown|positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartic protease activity involved in amyloid precursor protein degradation|positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process|positive regulation of aspartic-type endopeptidase activity involved in APP catabolism|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of aspartyl protease activity involved in APP catabolic process|positive regulation of aspartyl protease activity involved in APP catabolism|positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation|positive regulation of carboxyl protease activity involved in APP catabolic process|positive regulation of carboxyl protease activity involved in APP catabolism|positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation|up regulation of aspartate protease activity involved in APP catabolic process|up regulation of aspartate protease activity involved in APP catabolism|up regulation of aspartate protease activity involved in amyloid precursor protein breakdown|up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartate protease activity involved in amyloid precursor protein catabolism|up regulation of aspartate protease activity involved in amyloid precursor protein degradation|up regulation of aspartic endopeptidase activity involved in APP catabolic process|up regulation of aspartic endopeptidase activity involved in APP catabolism|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|up regulation of aspartic protease activity involved in APP catabolic process|up regulation of aspartic protease activity involved in APP catabolism|up regulation of aspartic protease activity involved in amyloid precursor protein breakdown|up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartic protease activity involved in amyloid precursor protein catabolism|up regulation of aspartic protease activity involved in amyloid precursor protein degradation|up regulation of aspartic-type endopeptidase activity involved in APP catabolic process|up regulation of aspartic-type endopeptidase activity involved in APP catabolism|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|up regulation of aspartyl protease activity involved in APP catabolic process|up regulation of aspartyl protease activity involved in APP catabolism|up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|up regulation of aspartyl protease activity involved in amyloid precursor protein degradation|up regulation of carboxyl protease activity involved in APP catabolic process|up regulation of carboxyl protease activity involved in APP catabolism|up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|up regulation of carboxyl protease activity involved in amyloid precursor protein degradation|up-regulation of aspartate protease activity involved in APP catabolic process|up-regulation of aspartate protease activity involved in APP catabolism|up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown|up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartate protease activity involved in amyloid precursor protein degradation|up-regulation of aspartic endopeptidase activity involved in APP catabolic process|up-regulation of aspartic endopeptidase activity involved in APP catabolism|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|up-regulation of aspartic protease activity involved in APP catabolic process|up-regulation of aspartic protease activity involved in APP catabolism|up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown|up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartic protease activity involved in amyloid precursor protein degradation|up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process|up-regulation of aspartic-type endopeptidase activity involved in APP catabolism|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|up-regulation of aspartyl protease activity involved in APP catabolic process|up-regulation of aspartyl protease activity involved in APP catabolism|up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation|up-regulation of carboxyl protease activity involved in APP catabolic process|up-regulation of carboxyl protease activity involved in APP catabolism|up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation|upregulation of aspartate protease activity involved in APP catabolic process|upregulation of aspartate protease activity involved in APP catabolism|upregulation of aspartate protease activity involved in amyloid precursor protein breakdown|upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process|upregulation of aspartate protease activity involved in amyloid precursor protein catabolism|upregulation of aspartate protease activity involved in amyloid precursor protein degradation|upregulation of aspartic endopeptidase activity involved in APP catabolic process|upregulation of aspartic endopeptidase activity involved in APP catabolism|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|upregulation of aspartic protease activity involved in APP catabolic process|upregulation of aspartic protease activity involved in APP catabolism|upregulation of aspartic protease activity involved in amyloid precursor protein breakdown|upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process|upregulation of aspartic protease activity involved in amyloid precursor protein catabolism|upregulation of aspartic protease activity involved in amyloid precursor protein degradation|upregulation of aspartic-type endopeptidase activity involved in APP catabolic process|upregulation of aspartic-type endopeptidase activity involved in APP catabolism|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|upregulation of aspartyl protease activity involved in APP catabolic process|upregulation of aspartyl protease activity involved in APP catabolism|upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown|upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism|upregulation of aspartyl protease activity involved in amyloid precursor protein degradation|upregulation of carboxyl protease activity involved in APP catabolic process|upregulation of carboxyl protease activity involved in APP catabolism|upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown|upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism|upregulation of carboxyl protease activity involved in amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902961 gocheck_do_not_annotate GO:1902979 biolink:BiologicalProcess mitotic DNA replication termination Any DNA replication termination involved in mitotic cell cycle DNA replication. go.json DNA replication termination involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902979 GO:1902977 biolink:BiologicalProcess mitotic DNA replication preinitiation complex assembly Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle. go.json DNA replication preinitiation complex formation involved in mitotic cell cycle|pre-IC complex assembly involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1902977 GO:1902978 biolink:BiologicalProcess premeiotic DNA replication termination Any DNA replication termination involved in meiotic cell cycle DNA replication. go.json DNA replication termination involved in meiotic DNA replication|DNA replication termination involved in meiotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902978 GO:1902975 biolink:BiologicalProcess mitotic DNA replication initiation Any DNA replication initiation involved in mitotic cell cycle DNA replication. go.json DNA replication initiation involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902975 GO:1902976 biolink:BiologicalProcess premeiotic DNA replication preinitiation complex assembly Any DNA replication preinitiation complex assembly that is involved in meiotic cell cycle. go.json DNA replication preinitiation complex formation involved in meiotic cell cycle|pre-IC complex assembly involved in meiotic cell cycle http://purl.obolibrary.org/obo/GO_1902976 GO:1902973 biolink:BiologicalProcess mitotic DNA replication DNA ligation Any DNA ligation involved in mitotic cell cycle DNA replication. go.json DNA ligation involved in mitotic DNA replication|DNA ligation involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902973 GO:1902974 biolink:BiologicalProcess meiotic DNA replication initiation Any DNA replication initiation involved in meiotic cell cycle DNA replication. go.json DNA replication initiation involved in meiotic DNA replication|DNA replication initiation involved in meiotic cell cycle DNA replication|initiation of meiotic DNA synthesis|initiation of premeiotic DNA replication|initiation of premeiotic DNA synthesis|premeiotic DNA replication initiation http://purl.obolibrary.org/obo/GO_1902974 GO:1902971 biolink:BiologicalProcess mitotic DNA replication DNA duplex unwinding Any DNA duplex unwinding involved in mitotic cell cycle DNA replication. go.json DNA duplex unwinding involved in mitotic DNA replication|DNA duplex unwinding involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902971 GO:1902972 biolink:BiologicalProcess premeiotic DNA replication DNA ligation Any DNA ligation involved in meiotic cell cycle DNA replication. go.json DNA ligation involved in meiotic DNA replication|DNA ligation involved in meiotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902972 GO:1902970 biolink:BiologicalProcess premeiotic DNA replication DNA duplex unwinding Any DNA duplex unwinding involved in meiotic cell cycle DNA replication. go.json DNA duplex unwinding involved in meiotic DNA replication|DNA duplex unwinding involved in meiotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902970 GO:1902988 biolink:BiologicalProcess neurofibrillary tangle assembly The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle. go.json flame-shaped neurofibrillary tangle assembly|flame-shaped neurofibrillary tangle formation|neurofibrillary tangle formation|star-shaped neurofibrillary tangle assembly|star-shaped neurofibrillary tangle formation http://purl.obolibrary.org/obo/GO_1902988 GO:1902989 biolink:BiologicalProcess meiotic telomere maintenance via semi-conservative replication Any telomere maintenance via semi-conservative replication that is involved in meiotic cell cycle. go.json equal telomere replication involved in meiotic cell cycle|telomeric fork progression involved in meiotic cell cycle|telomeric replication fork progression involved in meiotic cell cycle http://purl.obolibrary.org/obo/GO_1902989 GO:1902986 biolink:BiologicalProcess regulation of lysine biosynthetic process via aminoadipic acid Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid. go.json regulation of lysine anabolism via aminoadipic acid|regulation of lysine biosynthesis, aminoadipic acid pathway|regulation of lysine biosynthesis, aminoadipic pathway|regulation of lysine biosynthetic process, aminoadipic acid pathway|regulation of lysine biosynthetic process, aminoadipic pathway|regulation of lysine formation via aminoadipic acid|regulation of lysine synthesis via aminoadipic acid http://purl.obolibrary.org/obo/GO_1902986 GO:1902987 biolink:BiologicalProcess negative regulation of lysine biosynthetic process via aminoadipic acid Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid. go.json down regulation of lysine anabolism via aminoadipic acid|down regulation of lysine biosynthesis, aminoadipic acid pathway|down regulation of lysine biosynthesis, aminoadipic pathway|down regulation of lysine biosynthetic process via aminoadipic acid|down regulation of lysine biosynthetic process, aminoadipic acid pathway|down regulation of lysine biosynthetic process, aminoadipic pathway|down regulation of lysine formation via aminoadipic acid|down regulation of lysine synthesis via aminoadipic acid|down-regulation of lysine anabolism via aminoadipic acid|down-regulation of lysine biosynthesis, aminoadipic acid pathway|down-regulation of lysine biosynthesis, aminoadipic pathway|down-regulation of lysine biosynthetic process via aminoadipic acid|down-regulation of lysine biosynthetic process, aminoadipic acid pathway|down-regulation of lysine biosynthetic process, aminoadipic pathway|down-regulation of lysine formation via aminoadipic acid|down-regulation of lysine synthesis via aminoadipic acid|downregulation of lysine anabolism via aminoadipic acid|downregulation of lysine biosynthesis, aminoadipic acid pathway|downregulation of lysine biosynthesis, aminoadipic pathway|downregulation of lysine biosynthetic process via aminoadipic acid|downregulation of lysine biosynthetic process, aminoadipic acid pathway|downregulation of lysine biosynthetic process, aminoadipic pathway|downregulation of lysine formation via aminoadipic acid|downregulation of lysine synthesis via aminoadipic acid|inhibition of lysine anabolism via aminoadipic acid|inhibition of lysine biosynthesis, aminoadipic acid pathway|inhibition of lysine biosynthesis, aminoadipic pathway|inhibition of lysine biosynthetic process via aminoadipic acid|inhibition of lysine biosynthetic process, aminoadipic acid pathway|inhibition of lysine biosynthetic process, aminoadipic pathway|inhibition of lysine formation via aminoadipic acid|inhibition of lysine synthesis via aminoadipic acid|negative regulation of lysine anabolism via aminoadipic acid|negative regulation of lysine biosynthesis, aminoadipic acid pathway|negative regulation of lysine biosynthesis, aminoadipic pathway|negative regulation of lysine biosynthetic process, aminoadipic acid pathway|negative regulation of lysine biosynthetic process, aminoadipic pathway|negative regulation of lysine formation via aminoadipic acid|negative regulation of lysine synthesis via aminoadipic acid http://purl.obolibrary.org/obo/GO_1902987 GO:1902984 biolink:BiologicalProcess pre-replicative complex assembly involved in premeiotic DNA replication Any pre-replicative complex assembly involved in meiotic cell cycle DNA replication. go.json nuclear pre-replicative complex assembly involved in meiotic cell cycle|pre-RC complex assembly involved in meiosis|pre-replicative complex assembly involved in meiosis|pre-replicative complex assembly involved in meiotic cell cycle DNA replication|pre-replicative complex formation involved in meiosis http://purl.obolibrary.org/obo/GO_1902984 GO:1902985 biolink:BiologicalProcess mitotic pre-replicative complex assembly Any pre-replicative complex assembly involved in mitotic cell cycle DNA replication. go.json nuclear pre-replicative complex assembly involved in mitotic cell cycle|pre-replicative complex assembly involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902985 GO:1902982 biolink:BiologicalProcess DNA strand elongation involved in premeiotic DNA replication Any DNA strand elongation involved in meiotic cell cycle DNA replication. go.json DNA strand elongation involved in meiotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902982 GO:1902983 biolink:BiologicalProcess DNA strand elongation involved in mitotic DNA replication Any DNA strand elongation involved in mitotic cell cycle DNA replication. go.json DNA strand elongation involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902983 GO:1902980 biolink:BiologicalProcess synthesis of RNA primer involved in premeiotic DNA replication Any synthesis of RNA primer involved in meiotic cell cycle DNA replication. go.json synthesis of RNA primer involved in meiotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902980 GO:1902981 biolink:BiologicalProcess synthesis of RNA primer involved in mitotic DNA replication Any synthesis of RNA primer involved in mitotic cell cycle DNA replication. go.json synthesis of RNA primer involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1902981 GO:1902990 biolink:BiologicalProcess mitotic telomere maintenance via semi-conservative replication Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle. go.json equal telomere replication involved in mitotic cell cycle|telomeric fork progression involved in mitotic cell cycle|telomeric replication fork progression involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1902990 GO:1902999 biolink:BiologicalProcess negative regulation of phospholipid efflux Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid efflux. go.json down regulation of phospholipid efflux|down regulation of phospholipid export|down-regulation of phospholipid efflux|down-regulation of phospholipid export|downregulation of phospholipid efflux|downregulation of phospholipid export|inhibition of phospholipid efflux|inhibition of phospholipid export|negative regulation of phospholipid export http://purl.obolibrary.org/obo/GO_1902999 GO:1902997 biolink:BiologicalProcess negative regulation of neurofibrillary tangle assembly Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly. go.json down regulation of flame-shaped neurofibrillary tangle assembly|down regulation of flame-shaped neurofibrillary tangle formation|down regulation of neurofibrillary tangle assembly|down regulation of neurofibrillary tangle formation|down regulation of star-shaped neurofibrillary tangle assembly|down regulation of star-shaped neurofibrillary tangle formation|down-regulation of flame-shaped neurofibrillary tangle assembly|down-regulation of flame-shaped neurofibrillary tangle formation|down-regulation of neurofibrillary tangle assembly|down-regulation of neurofibrillary tangle formation|down-regulation of star-shaped neurofibrillary tangle assembly|down-regulation of star-shaped neurofibrillary tangle formation|downregulation of flame-shaped neurofibrillary tangle assembly|downregulation of flame-shaped neurofibrillary tangle formation|downregulation of neurofibrillary tangle assembly|downregulation of neurofibrillary tangle formation|downregulation of star-shaped neurofibrillary tangle assembly|downregulation of star-shaped neurofibrillary tangle formation|inhibition of flame-shaped neurofibrillary tangle assembly|inhibition of flame-shaped neurofibrillary tangle formation|inhibition of neurofibrillary tangle assembly|inhibition of neurofibrillary tangle formation|inhibition of star-shaped neurofibrillary tangle assembly|inhibition of star-shaped neurofibrillary tangle formation|negative regulation of flame-shaped neurofibrillary tangle assembly|negative regulation of flame-shaped neurofibrillary tangle formation|negative regulation of neurofibrillary tangle formation|negative regulation of star-shaped neurofibrillary tangle assembly|negative regulation of star-shaped neurofibrillary tangle formation http://purl.obolibrary.org/obo/GO_1902997 GO:1902998 biolink:BiologicalProcess positive regulation of neurofibrillary tangle assembly Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly. go.json activation of flame-shaped neurofibrillary tangle assembly|activation of flame-shaped neurofibrillary tangle formation|activation of neurofibrillary tangle assembly|activation of neurofibrillary tangle formation|activation of star-shaped neurofibrillary tangle assembly|activation of star-shaped neurofibrillary tangle formation|positive regulation of flame-shaped neurofibrillary tangle assembly|positive regulation of flame-shaped neurofibrillary tangle formation|positive regulation of neurofibrillary tangle formation|positive regulation of star-shaped neurofibrillary tangle assembly|positive regulation of star-shaped neurofibrillary tangle formation|up regulation of flame-shaped neurofibrillary tangle assembly|up regulation of flame-shaped neurofibrillary tangle formation|up regulation of neurofibrillary tangle assembly|up regulation of neurofibrillary tangle formation|up regulation of star-shaped neurofibrillary tangle assembly|up regulation of star-shaped neurofibrillary tangle formation|up-regulation of flame-shaped neurofibrillary tangle assembly|up-regulation of flame-shaped neurofibrillary tangle formation|up-regulation of neurofibrillary tangle assembly|up-regulation of neurofibrillary tangle formation|up-regulation of star-shaped neurofibrillary tangle assembly|up-regulation of star-shaped neurofibrillary tangle formation|upregulation of flame-shaped neurofibrillary tangle assembly|upregulation of flame-shaped neurofibrillary tangle formation|upregulation of neurofibrillary tangle assembly|upregulation of neurofibrillary tangle formation|upregulation of star-shaped neurofibrillary tangle assembly|upregulation of star-shaped neurofibrillary tangle formation http://purl.obolibrary.org/obo/GO_1902998 GO:1902995 biolink:BiologicalProcess positive regulation of phospholipid efflux Any process that activates or increases the frequency, rate or extent of phospholipid efflux. go.json activation of phospholipid efflux|activation of phospholipid export|positive regulation of phospholipid export|up regulation of phospholipid efflux|up regulation of phospholipid export|up-regulation of phospholipid efflux|up-regulation of phospholipid export|upregulation of phospholipid efflux|upregulation of phospholipid export http://purl.obolibrary.org/obo/GO_1902995 GO:1902996 biolink:BiologicalProcess regulation of neurofibrillary tangle assembly Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly. go.json regulation of flame-shaped neurofibrillary tangle assembly|regulation of flame-shaped neurofibrillary tangle formation|regulation of neurofibrillary tangle formation|regulation of star-shaped neurofibrillary tangle assembly|regulation of star-shaped neurofibrillary tangle formation http://purl.obolibrary.org/obo/GO_1902996 GO:1902993 biolink:BiologicalProcess positive regulation of amyloid precursor protein catabolic process Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process. go.json activation of APP catabolic process|activation of APP catabolism|activation of amyloid precursor protein breakdown|activation of amyloid precursor protein catabolic process|activation of amyloid precursor protein catabolism|activation of amyloid precursor protein degradation|positive regulation of APP catabolic process|positive regulation of APP catabolism|positive regulation of amyloid precursor protein breakdown|positive regulation of amyloid precursor protein catabolism|positive regulation of amyloid precursor protein degradation|up regulation of APP catabolic process|up regulation of APP catabolism|up regulation of amyloid precursor protein breakdown|up regulation of amyloid precursor protein catabolic process|up regulation of amyloid precursor protein catabolism|up regulation of amyloid precursor protein degradation|up-regulation of APP catabolic process|up-regulation of APP catabolism|up-regulation of amyloid precursor protein breakdown|up-regulation of amyloid precursor protein catabolic process|up-regulation of amyloid precursor protein catabolism|up-regulation of amyloid precursor protein degradation|upregulation of APP catabolic process|upregulation of APP catabolism|upregulation of amyloid precursor protein breakdown|upregulation of amyloid precursor protein catabolic process|upregulation of amyloid precursor protein catabolism|upregulation of amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902993 GO:1902994 biolink:BiologicalProcess regulation of phospholipid efflux Any process that modulates the frequency, rate or extent of phospholipid efflux. go.json regulation of phospholipid export http://purl.obolibrary.org/obo/GO_1902994 GO:1902991 biolink:BiologicalProcess regulation of amyloid precursor protein catabolic process Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. go.json regulation of APP catabolic process|regulation of APP catabolism|regulation of amyloid precursor protein breakdown|regulation of amyloid precursor protein catabolism|regulation of amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902991 GO:1902992 biolink:BiologicalProcess negative regulation of amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process. go.json down regulation of APP catabolic process|down regulation of APP catabolism|down regulation of amyloid precursor protein breakdown|down regulation of amyloid precursor protein catabolic process|down regulation of amyloid precursor protein catabolism|down regulation of amyloid precursor protein degradation|down-regulation of APP catabolic process|down-regulation of APP catabolism|down-regulation of amyloid precursor protein breakdown|down-regulation of amyloid precursor protein catabolic process|down-regulation of amyloid precursor protein catabolism|down-regulation of amyloid precursor protein degradation|downregulation of APP catabolic process|downregulation of APP catabolism|downregulation of amyloid precursor protein breakdown|downregulation of amyloid precursor protein catabolic process|downregulation of amyloid precursor protein catabolism|downregulation of amyloid precursor protein degradation|inhibition of APP catabolic process|inhibition of APP catabolism|inhibition of amyloid precursor protein breakdown|inhibition of amyloid precursor protein catabolic process|inhibition of amyloid precursor protein catabolism|inhibition of amyloid precursor protein degradation|negative regulation of APP catabolic process|negative regulation of APP catabolism|negative regulation of amyloid precursor protein breakdown|negative regulation of amyloid precursor protein catabolism|negative regulation of amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_1902992 GO:0034613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034613 GO:0010646 biolink:BiologicalProcess regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json http://purl.obolibrary.org/obo/GO_0010646 GO:0010647 biolink:BiologicalProcess positive regulation of cell communication Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json http://purl.obolibrary.org/obo/GO_0010647 GO:0034614 biolink:BiologicalProcess cellular response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. go.json cellular response to AOS|cellular response to ROI|cellular response to ROS|cellular response to active oxygen species|cellular response to reactive oxidative species|cellular response to reactive oxygen intermediate http://purl.obolibrary.org/obo/GO_0034614 GO:0010644 biolink:BiologicalProcess cell communication by electrical coupling The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010644 GO:0034615 biolink:CellularComponent GCH1 complex A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive. go.json GTP cyclohydrolase I complex http://purl.obolibrary.org/obo/GO_0034615 GO:0034616 biolink:BiologicalProcess response to laminar fluid shear stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. go.json http://purl.obolibrary.org/obo/GO_0034616 GO:0010645 biolink:BiologicalProcess regulation of cell communication by chemical coupling Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010645 GO:0034617 biolink:MolecularActivity tetrahydrobiopterin binding Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions. go.json BH4 binding|H4biopterin binding|sapropterin binding http://purl.obolibrary.org/obo/GO_0034617 GO:0034618 biolink:MolecularActivity arginine binding Binding to 2-amino-5-(carbamimidamido)pentanoic acid. go.json Arg binding|aminopentanoic acid binding http://purl.obolibrary.org/obo/GO_0034618 GO:0010648 biolink:BiologicalProcess negative regulation of cell communication Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json http://purl.obolibrary.org/obo/GO_0010648 GO:0034619 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034619 GO:0010649 biolink:BiologicalProcess regulation of cell communication by electrical coupling Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010649 GO:0009650 biolink:BiologicalProcess UV protection Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. go.json UV resistance|UV tolerance|ultraviolet protection|ultraviolet resistance|ultraviolet tolerance http://purl.obolibrary.org/obo/GO_0009650 GO:0009651 biolink:BiologicalProcess response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json response to ionic osmotic stress|salinity response http://purl.obolibrary.org/obo/GO_0009651 GO:0009652 biolink:BiologicalProcess thigmotropism The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it. Wikipedia:Thigmotropism go.json http://purl.obolibrary.org/obo/GO_0009652 GO:0009653 biolink:BiologicalProcess anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. Wikipedia:Morphogenesis go.json anatomical structure organization|embryogenesis and morphogenesis|morphogenesis http://purl.obolibrary.org/obo/GO_0009653 GO:0010642 biolink:BiologicalProcess negative regulation of platelet-derived growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. go.json negative regulation of platelet-derived growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0010642 GO:0034610 biolink:MolecularActivity oligodeoxyribonucleotidase activity Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates. go.json DNA oligonucleotidase activity http://purl.obolibrary.org/obo/GO_0034610 GO:0010643 biolink:BiologicalProcess cell communication by chemical coupling The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010643 GO:0009654 biolink:CellularComponent photosystem II oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). Wikipedia:Oxygen_evolving_complex go.json OEC (PSII) complex|oxygen evolving complex http://purl.obolibrary.org/obo/GO_0009654 GO:0009655 biolink:CellularComponent PSII associated light-harvesting complex II, core complex The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center. go.json PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex|PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex|PSII associated light-harvesting complex II, core complex, LHCIId subcomplex http://purl.obolibrary.org/obo/GO_0009655 GO:0010640 biolink:BiologicalProcess regulation of platelet-derived growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. go.json regulation of platelet-derived growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0010640 GO:0034611 biolink:MolecularActivity oligoribonucleotidase activity Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates. Reactome:R-HSA-9009950|Reactome:R-HSA-9615042 go.json RNA oligonucleotidase activity http://purl.obolibrary.org/obo/GO_0034611 GO:0009656 biolink:CellularComponent PSII associated light-harvesting complex II, peripheral complex Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light. go.json http://purl.obolibrary.org/obo/GO_0009656 GO:0010641 biolink:BiologicalProcess positive regulation of platelet-derived growth factor receptor signaling pathway Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. go.json positive regulation of platelet-derived growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0010641 GO:0034612 biolink:BiologicalProcess response to tumor necrosis factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. go.json response to TNF http://purl.obolibrary.org/obo/GO_0034612 GO:0009657 biolink:BiologicalProcess plastid organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid. go.json plastid organisation|plastid organization and biogenesis http://purl.obolibrary.org/obo/GO_0009657 goslim_pir GO:0009658 biolink:BiologicalProcess chloroplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast. go.json chloroplast organisation|chloroplast organization and biogenesis http://purl.obolibrary.org/obo/GO_0009658 GO:0009659 biolink:BiologicalProcess leucoplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes. go.json leucoplast organisation|leucoplast organization and biogenesis http://purl.obolibrary.org/obo/GO_0009659 GO:0034602 biolink:MolecularActivity oxoglutarate dehydrogenase (NAD+) activity Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH. EC:1.2.1.105|KEGG_REACTION:R08549|MetaCyc:2OXOGLUTARATEDEH-RXN|RHEA:27786|Reactome:R-HSA-71037|Reactome:R-HSA-71401 go.json http://purl.obolibrary.org/obo/GO_0034602 GO:0010657 biolink:BiologicalProcess muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. go.json muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010657 GO:0010658 biolink:BiologicalProcess striated muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. go.json striated muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010658 GO:0034603 biolink:MolecularActivity pyruvate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. go.json http://purl.obolibrary.org/obo/GO_0034603 GO:0034604 biolink:MolecularActivity pyruvate dehydrogenase (NAD+) activity Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH. KEGG_REACTION:R00209|MetaCyc:PYRUVDEH-RXN|RHEA:28042 go.json http://purl.obolibrary.org/obo/GO_0034604 GO:0010655 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010655 GO:0034605 biolink:BiologicalProcess cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. go.json cellular response to heat stress http://purl.obolibrary.org/obo/GO_0034605 GO:0010656 biolink:BiologicalProcess negative regulation of muscle cell apoptotic process Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. go.json negative regulation of muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010656 GO:0034606 biolink:BiologicalProcess response to hermaphrodite contact The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate. go.json http://purl.obolibrary.org/obo/GO_0034606 GO:0034607 biolink:BiologicalProcess turning behavior involved in mating The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. go.json turning behavior during mating http://purl.obolibrary.org/obo/GO_0034607 GO:0010659 biolink:BiologicalProcess cardiac muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. go.json cardiac muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010659 GO:0034608 biolink:BiologicalProcess vulval location Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate. go.json http://purl.obolibrary.org/obo/GO_0034608 GO:0034609 biolink:BiologicalProcess spicule insertion Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. go.json http://purl.obolibrary.org/obo/GO_0034609 GO:0009670 biolink:MolecularActivity triose-phosphate:phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out). go.json TPT|dihydroxyacetone phosphate:phosphate antiporter activity|triose phosphate antiporter|triose phosphate translocator http://purl.obolibrary.org/obo/GO_0009670 GO:0009660 biolink:BiologicalProcess amyloplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch. go.json amyloplast organisation|amyloplast organization and biogenesis http://purl.obolibrary.org/obo/GO_0009660 GO:0009661 biolink:BiologicalProcess chromoplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments. go.json chromoplast organisation|chromoplast organization and biogenesis http://purl.obolibrary.org/obo/GO_0009661 GO:0010650 biolink:BiologicalProcess positive regulation of cell communication by electrical coupling Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010650 GO:0009662 biolink:BiologicalProcess etioplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions. go.json etioplast organisation|etioplast organization and biogenesis http://purl.obolibrary.org/obo/GO_0009662 GO:0009663 biolink:BiologicalProcess plasmodesma organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. go.json plasmodesma organisation|plasmodesma organization and biogenesis|plasmodesmata organization and biogenesis http://purl.obolibrary.org/obo/GO_0009663 GO:0010653 biolink:BiologicalProcess negative regulation of cell communication by chemical coupling Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010653 GO:0009664 biolink:BiologicalProcess plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. go.json cell wall organization and biogenesis|cellulose and pectin-containing cell wall organization and biogenesis|plant-type cell wall organisation|plant-type cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0009664 GO:0009665 biolink:BiologicalProcess plastid inheritance The partitioning of plastids between daughter cells at cell division. go.json http://purl.obolibrary.org/obo/GO_0009665 GO:0010654 biolink:BiologicalProcess apical cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote. go.json http://purl.obolibrary.org/obo/GO_0010654 GO:0009666 biolink:BiologicalProcess plastid outer membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid. go.json plastid outer membrane organisation|plastid outer membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0009666 GO:0034600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034600 GO:0010651 biolink:BiologicalProcess negative regulation of cell communication by electrical coupling Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010651 GO:0010652 biolink:BiologicalProcess positive regulation of cell communication by chemical coupling Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0010652 GO:0009667 biolink:BiologicalProcess plastid inner membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid. go.json plastid inner membrane organisation|plastid inner membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0009667 GO:0034601 biolink:MolecularActivity oxoglutarate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H. EC:1.2.1.52 go.json http://purl.obolibrary.org/obo/GO_0034601 GO:0009668 biolink:BiologicalProcess plastid membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid. go.json plastid membrane organisation|plastid membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0009668 GO:0009669 biolink:MolecularActivity sucrose:monoatomic cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in). go.json sucrose permease activity|sucrose:cation symporter activity|sucrose:monovalent cation symporter activity http://purl.obolibrary.org/obo/GO_0009669 GO:0010624 biolink:BiologicalProcess regulation of Schwann cell proliferation Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. go.json http://purl.obolibrary.org/obo/GO_0010624 GO:0010625 biolink:BiologicalProcess positive regulation of Schwann cell proliferation Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. go.json http://purl.obolibrary.org/obo/GO_0010625 GO:0010622 biolink:BiologicalProcess specification of ovule identity The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010622 GO:0010623 biolink:BiologicalProcess programmed cell death involved in cell development The activation of endogenous cellular processes that result in the death of a cell as part of its development. go.json developmental programmed cell death|programmed cell death involved in development http://purl.obolibrary.org/obo/GO_0010623 GO:0010628 biolink:BiologicalProcess positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). go.json http://purl.obolibrary.org/obo/GO_0010628 GO:0010629 biolink:BiologicalProcess negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). go.json gene silencing http://purl.obolibrary.org/obo/GO_0010629 GO:0010626 biolink:BiologicalProcess negative regulation of Schwann cell proliferation Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. go.json http://purl.obolibrary.org/obo/GO_0010626 GO:0010627 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010627 GO:0009630 biolink:BiologicalProcess gravitropism The orientation of plant parts under the stimulation of gravity. Wikipedia:Gravitropism go.json geotropism http://purl.obolibrary.org/obo/GO_0009630 GO:0010620 biolink:BiologicalProcess negative regulation of transcription by transcription factor catabolism Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. go.json http://purl.obolibrary.org/obo/GO_0010620 GO:0009631 biolink:BiologicalProcess cold acclimation Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures. go.json http://purl.obolibrary.org/obo/GO_0009631 GO:0009632 biolink:BiologicalProcess obsolete freezing tolerance OBSOLETE. (Was not defined before being made obsolete). go.json freezing tolerance True http://purl.obolibrary.org/obo/GO_0009632 GO:0010621 biolink:BiologicalProcess negative regulation of transcription by transcription factor localization Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. go.json negative regulation of transcription by transcription factor localisation http://purl.obolibrary.org/obo/GO_0010621 GO:0009633 biolink:BiologicalProcess obsolete drought tolerance OBSOLETE. (Was not defined before being made obsolete). go.json drought tolerance True http://purl.obolibrary.org/obo/GO_0009633 GO:0009634 biolink:BiologicalProcess obsolete heavy metal sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json heavy metal sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0009634 GO:0009635 biolink:BiologicalProcess response to herbicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants. go.json herbicide susceptibility/resistance http://purl.obolibrary.org/obo/GO_0009635 GO:0009636 biolink:BiologicalProcess response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. go.json detoxification response|toxin resistance|toxin susceptibility/resistance http://purl.obolibrary.org/obo/GO_0009636 goslim_chembl GO:0009637 biolink:BiologicalProcess response to blue light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. go.json blue light response|blue-light response|response to blue light stimulus http://purl.obolibrary.org/obo/GO_0009637 GO:0009638 biolink:BiologicalProcess phototropism The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it. Wikipedia:Phototropism go.json http://purl.obolibrary.org/obo/GO_0009638 GO:0009639 biolink:BiologicalProcess response to red or far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json http://purl.obolibrary.org/obo/GO_0009639 GO:0010635 biolink:BiologicalProcess regulation of mitochondrial fusion Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. go.json http://purl.obolibrary.org/obo/GO_0010635 GO:0010636 biolink:BiologicalProcess positive regulation of mitochondrial fusion Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. go.json http://purl.obolibrary.org/obo/GO_0010636 GO:0010633 biolink:BiologicalProcess negative regulation of epithelial cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. go.json http://purl.obolibrary.org/obo/GO_0010633 GO:0010634 biolink:BiologicalProcess positive regulation of epithelial cell migration Any process that activates or increases the frequency, rate or extent of epithelial cell migration. go.json http://purl.obolibrary.org/obo/GO_0010634 GO:0010639 biolink:BiologicalProcess negative regulation of organelle organization Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. go.json negative regulation of organelle organisation|negative regulation of organelle organization and biogenesis http://purl.obolibrary.org/obo/GO_0010639 GO:0010637 biolink:BiologicalProcess negative regulation of mitochondrial fusion Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. go.json http://purl.obolibrary.org/obo/GO_0010637 GO:0010638 biolink:BiologicalProcess positive regulation of organelle organization Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. go.json positive regulation of organelle organisation|positive regulation of organelle organization and biogenesis http://purl.obolibrary.org/obo/GO_0010638 GO:0009640 biolink:BiologicalProcess photomorphogenesis The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis. Wikipedia:Photomorphogenesis go.json plant development in response to light http://purl.obolibrary.org/obo/GO_0009640 GO:0009641 biolink:BiologicalProcess shade avoidance Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome. Wikipedia:Shade_avoidance go.json http://purl.obolibrary.org/obo/GO_0009641 GO:0009642 biolink:BiologicalProcess response to light intensity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. go.json http://purl.obolibrary.org/obo/GO_0009642 GO:0010631 biolink:BiologicalProcess epithelial cell migration The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0010631 GO:0010632 biolink:BiologicalProcess regulation of epithelial cell migration Any process that modulates the frequency, rate or extent of epithelial cell migration. go.json http://purl.obolibrary.org/obo/GO_0010632 GO:0009643 biolink:BiologicalProcess photosynthetic acclimation A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light. go.json light acclimatization|photoacclimation http://purl.obolibrary.org/obo/GO_0009643 GO:0009644 biolink:BiologicalProcess response to high light intensity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. go.json http://purl.obolibrary.org/obo/GO_0009644 GO:0009645 biolink:BiologicalProcess response to low light intensity stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2. go.json http://purl.obolibrary.org/obo/GO_0009645 GO:0010630 biolink:BiologicalProcess regulation of transcription, start site selection Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template. go.json http://purl.obolibrary.org/obo/GO_0010630 GO:0009646 biolink:BiologicalProcess response to absence of light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. go.json response to darkness http://purl.obolibrary.org/obo/GO_0009646 GO:0009647 biolink:BiologicalProcess skotomorphogenesis The control of plant growth, development, and differentiation in response to growth in darkness. go.json etiolation http://purl.obolibrary.org/obo/GO_0009647 GO:0009648 biolink:BiologicalProcess photoperiodism Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. Wikipedia:Photoperiodism go.json response to day length|response to night length|response to photoperiod http://purl.obolibrary.org/obo/GO_0009648 GO:0009649 biolink:BiologicalProcess entrainment of circadian clock The synchronization of a circadian rhythm to environmental time cues such as light. go.json regulation of circadian rhythm phase http://purl.obolibrary.org/obo/GO_0009649 GO:0010608 biolink:BiologicalProcess post-transcriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. go.json posttranscriptional regulation of gene expression http://purl.obolibrary.org/obo/GO_0010608 GO:0010609 biolink:BiologicalProcess mRNA localization resulting in post-transcriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell. go.json mRNA localisation resulting in posttranscriptional regulation of gene expression|mRNA localization resulting in posttranscriptional regulation of gene expression|posttranscriptional regulation of gene expression by mRNA localisation|posttranscriptional regulation of gene expression by mRNA localization http://purl.obolibrary.org/obo/GO_0010609 GO:0010602 biolink:BiologicalProcess regulation of 1-aminocyclopropane-1-carboxylate metabolic process Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. go.json http://purl.obolibrary.org/obo/GO_0010602 GO:0010603 biolink:BiologicalProcess regulation of cytoplasmic mRNA processing body assembly Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. go.json http://purl.obolibrary.org/obo/GO_0010603 GO:0010600 biolink:BiologicalProcess regulation of auxin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. go.json http://purl.obolibrary.org/obo/GO_0010600 GO:0010601 biolink:BiologicalProcess positive regulation of auxin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. go.json http://purl.obolibrary.org/obo/GO_0010601 GO:0010606 biolink:BiologicalProcess positive regulation of cytoplasmic mRNA processing body assembly Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. go.json http://purl.obolibrary.org/obo/GO_0010606 GO:0010607 biolink:BiologicalProcess negative regulation of cytoplasmic mRNA processing body assembly Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. go.json http://purl.obolibrary.org/obo/GO_0010607 GO:0010604 biolink:BiologicalProcess positive regulation of macromolecule metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json http://purl.obolibrary.org/obo/GO_0010604 GO:0010605 biolink:BiologicalProcess negative regulation of macromolecule metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json http://purl.obolibrary.org/obo/GO_0010605 GO:0009610 biolink:BiologicalProcess response to symbiotic fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism. go.json response to symbiotic fungi http://purl.obolibrary.org/obo/GO_0009610 GO:0009611 biolink:BiologicalProcess response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. go.json physiological response to wounding http://purl.obolibrary.org/obo/GO_0009611 GO:0009612 biolink:BiologicalProcess response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. go.json chemi-mechanical coupling|mechanical stimulus response http://purl.obolibrary.org/obo/GO_0009612 GO:0009613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009613 GO:0009614 biolink:BiologicalProcess obsolete disease resistance OBSOLETE. (Was not defined before being made obsolete). go.json disease resistance True http://purl.obolibrary.org/obo/GO_0009614 GO:0009615 biolink:BiologicalProcess response to virus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. go.json response to viruses http://purl.obolibrary.org/obo/GO_0009615 GO:0009616 biolink:BiologicalProcess RNAi-mediated antiviral immune response A post-transcriptional gene silencing pathway mediated by the action of regulatory RNAs that protects against foreign organism invasion by restricting viral replication and dissemination. go.json RNAi-mediated antiviral immunity|VIGS|viral gene silencing in virus induced gene silencing|viral triggering of virus induced gene silencing|virus induced gene silencing|virus-induced PTGS|virus-induced gene silencing http://purl.obolibrary.org/obo/GO_0009616 GO:0009617 biolink:BiologicalProcess response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. go.json response to bacteria http://purl.obolibrary.org/obo/GO_0009617 GO:0009618 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009618 GO:0009619 biolink:BiologicalProcess obsolete resistance to pathogenic bacteria OBSOLETE. (Was not defined before being made obsolete). go.json resistance to pathogenic bacteria True http://purl.obolibrary.org/obo/GO_0009619 GO:0010619 biolink:BiologicalProcess adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by glucose binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. go.json activation of adenylate cyclase activity by glucose involved in G-protein signaling|activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway|activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway|glucose-sensing PKA pathway http://purl.obolibrary.org/obo/GO_0010619 GO:0010613 biolink:BiologicalProcess positive regulation of cardiac muscle hypertrophy Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. go.json http://purl.obolibrary.org/obo/GO_0010613 GO:0010614 biolink:BiologicalProcess negative regulation of cardiac muscle hypertrophy Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. go.json http://purl.obolibrary.org/obo/GO_0010614 GO:0010611 biolink:BiologicalProcess regulation of cardiac muscle hypertrophy Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. go.json http://purl.obolibrary.org/obo/GO_0010611 GO:0010612 biolink:BiologicalProcess regulation of cardiac muscle adaptation Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. go.json http://purl.obolibrary.org/obo/GO_0010612 GO:0010617 biolink:BiologicalProcess circadian regulation of calcium ion oscillation Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours. go.json circadian regulation of Ca2+ oscillation|circadian regulation of [Ca2+]cyt oscillation|circadian regulation of cytosolic calcium ion homeostasis|circadian regulation of cytosolic free calcium ion oscillation http://purl.obolibrary.org/obo/GO_0010617 GO:0010618 biolink:BiologicalProcess aerenchyma formation The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0010618 GO:0010615 biolink:BiologicalProcess positive regulation of cardiac muscle adaptation Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. go.json http://purl.obolibrary.org/obo/GO_0010615 GO:0010616 biolink:BiologicalProcess negative regulation of cardiac muscle adaptation Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. go.json http://purl.obolibrary.org/obo/GO_0010616 GO:0009620 biolink:BiologicalProcess response to fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. go.json response to fungi http://purl.obolibrary.org/obo/GO_0009620 GO:0010610 biolink:BiologicalProcess regulation of mRNA stability involved in response to stress Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance. go.json http://purl.obolibrary.org/obo/GO_0010610 GO:0009621 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009621 GO:0009622 biolink:BiologicalProcess obsolete resistance to pathogenic fungi OBSOLETE. (Was not defined before being made obsolete). go.json resistance to pathogenic fungi True http://purl.obolibrary.org/obo/GO_0009622 GO:0009623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009623 GO:0009624 biolink:BiologicalProcess response to nematode Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. go.json response to nematodes http://purl.obolibrary.org/obo/GO_0009624 GO:0009625 biolink:BiologicalProcess response to insect Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect. go.json response to insects http://purl.obolibrary.org/obo/GO_0009625 GO:0009626 biolink:BiologicalProcess plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen. go.json HR|HR-PCD|plant hypersensitive response http://purl.obolibrary.org/obo/GO_0009626 GO:0009627 biolink:BiologicalProcess systemic acquired resistance The salicylic acid mediated response to a pathogen which confers broad spectrum resistance. Wikipedia:Systemic_acquired_resistance go.json salicylic acid-dependent systemic resistance http://purl.obolibrary.org/obo/GO_0009627 GO:0009628 biolink:BiologicalProcess response to abiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. go.json response to abiotic stress http://purl.obolibrary.org/obo/GO_0009628 gocheck_do_not_manually_annotate|goslim_metagenomics|goslim_plant GO:0009629 biolink:BiologicalProcess response to gravity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. go.json response to gravitational stimulus http://purl.obolibrary.org/obo/GO_0009629 GO:0044005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044005 GO:0044006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044006 GO:0044003 biolink:BiologicalProcess modulation by symbiont of host process The process in which a symbiont organism effects a change in the structure or processes of its host organism. go.json disruption by symbiont of host cell|modification by symbiont of host biological process|modification by symbiont of host morphology or physiology|modulation by symbiont of host system process|pathogenesis|regulation by symbiont of host system process http://purl.obolibrary.org/obo/GO_0044003 GO:0044004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044004 GO:0044001 biolink:BiologicalProcess migration in host The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json migration within host http://purl.obolibrary.org/obo/GO_0044001 GO:0044002 biolink:BiologicalProcess acquisition of nutrients from host The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044002 GO:0044000 biolink:BiologicalProcess movement in host The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json movement in host environment|movement of symbiont in host|movement of symbiont within host|movement within host|symbiont movement in host|symbiont movement within host http://purl.obolibrary.org/obo/GO_0044000 GO:0044009 biolink:BiologicalProcess obsolete viral transmission by vector OBSOLETE. The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection. go.json True http://purl.obolibrary.org/obo/GO_0044009 GO:0044007 biolink:BiologicalProcess obsolete dissemination or transmission of symbiont from host OBSOLETE. The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json dissemination or transmission of organism from host True http://purl.obolibrary.org/obo/GO_0044007 GO:0044008 biolink:BiologicalProcess obsolete dissemination or transmission of symbiont from host by vector OBSOLETE. The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json dissemination or transmission of organism from host by vector True http://purl.obolibrary.org/obo/GO_0044008 GO:0044016 biolink:MolecularActivity histone H3K4 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4). go.json histone H3-K4 acetyltransferase activity|histone acetylase activity (H3-K4 specific)|histone acetyltransferase activity (H3-K4 specific)|histone lysine N-acetyltransferase activity (H3-K4 specific) http://purl.obolibrary.org/obo/GO_0044016 GO:0044017 biolink:MolecularActivity histone H3K27 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27). go.json histone H3-K27 acetyltransferase activity|histone acetylase activity (H3-K27 specific)|histone acetyltransferase activity (H3-K27 specific)|histone lysine N-acetyltransferase activity (H3-K27 specific) http://purl.obolibrary.org/obo/GO_0044017 GO:0044014 biolink:MolecularActivity histone H2BK5 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5). go.json histone acetylase activity (H2B-K5 specific)|histone acetyltransferase activity (H2B-K5 specific)|histone lysine N-acetyltransferase activity (H2B-K5 specific) http://purl.obolibrary.org/obo/GO_0044014 GO:0044015 biolink:MolecularActivity histone H2BK12 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12). go.json histone H2B-K12 acetyltransferase activity|histone acetylase activity (H2B-K12 specific)|histone acetyltransferase activity (H2B-K12 specific)|histone lysine N-acetyltransferase activity (H2B-K12 specific) http://purl.obolibrary.org/obo/GO_0044015 GO:0044012 biolink:MolecularActivity histone H2AK9 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9). go.json histone H2A-K9 acetyltransferase activity|histone acetylase activity (H2A-K9 specific)|histone acetyltransferase activity (H2A-K9 specific)|histone lysine N-acetyltransferase activity (H2A-K9 specific) http://purl.obolibrary.org/obo/GO_0044012 GO:0044013 biolink:MolecularActivity histone H2B acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine. go.json H2B histone acetylase activity|H2B histone acetyltransferase activity|H2B histone lysine N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0044013 GO:0044010 biolink:BiologicalProcess single-species biofilm formation A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. go.json auto-aggregation|bfp-dependent aggregation|bundle-forming fimbriae-dependent aggregation|bundle-forming pili-dependent aggregation|tfp-dependent aggregation|type IV pili-dependent aggregation http://purl.obolibrary.org/obo/GO_0044010 GO:0044011 biolink:BiologicalProcess single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. go.json http://purl.obolibrary.org/obo/GO_0044011 GO:0044018 biolink:MolecularActivity histone H3K36 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36). go.json histone H3-K36 acetyltransferase activity|histone acetylase activity (H3-K36 specific)|histone acetyltransferase activity (H3-K36 specific)|histone lysine N-acetyltransferase activity (H3-K36 specific) http://purl.obolibrary.org/obo/GO_0044018 GO:0009600 biolink:BiologicalProcess detection of nematode The series of events in which a stimulus from a nematode is received and converted into a molecular signal. go.json perception of nematode http://purl.obolibrary.org/obo/GO_0009600 GO:0044019 biolink:MolecularActivity histone H3K72 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72). go.json histone H3-K72 acetyltransferase activity|histone acetylase activity (H3-K72 specific)|histone acetyltransferase activity (H3-K72 specific)|histone lysine N-acetyltransferase activity (H3-K72 specific) http://purl.obolibrary.org/obo/GO_0044019 GO:0009601 biolink:BiologicalProcess detection of insect The series of events in which a stimulus from an insect is received and converted into a molecular signal. go.json perception of insect http://purl.obolibrary.org/obo/GO_0009601 GO:0009602 biolink:BiologicalProcess detection of symbiont The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json perception of symbiont|recognition of symbiont http://purl.obolibrary.org/obo/GO_0009602 GO:0009603 biolink:BiologicalProcess detection of symbiotic fungus The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal. go.json detection of symbiotic fungi|perception of symbiotic fungi|perception of symbiotic fungus http://purl.obolibrary.org/obo/GO_0009603 GO:0009604 biolink:BiologicalProcess detection of symbiotic bacterium The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal. go.json detection of symbiotic bacteria|perception of symbiotic bacteria|perception of symbiotic bacterium http://purl.obolibrary.org/obo/GO_0009604 GO:0009605 biolink:BiologicalProcess response to external stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. go.json response to environmental stimulus http://purl.obolibrary.org/obo/GO_0009605 gocheck_do_not_manually_annotate|goslim_drosophila|goslim_plant GO:0009606 biolink:BiologicalProcess tropism The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it. Wikipedia:Tropism go.json http://purl.obolibrary.org/obo/GO_0009606 goslim_plant GO:0009607 biolink:BiologicalProcess response to biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. go.json response to biotic stress http://purl.obolibrary.org/obo/GO_0009607 gocheck_do_not_manually_annotate|goslim_metagenomics|goslim_plant GO:0009608 biolink:BiologicalProcess response to symbiont Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json response of host to symbiont http://purl.obolibrary.org/obo/GO_0009608 GO:0009609 biolink:BiologicalProcess response to symbiotic bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism. go.json response to symbiotic bacteria http://purl.obolibrary.org/obo/GO_0009609 GO:0019063 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019063 GO:0019064 biolink:BiologicalProcess fusion of virus membrane with host plasma membrane Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm. VZ:987 go.json viral entry into host cell via membrane fusion with the plasma membrane|viral envelope fusion|viral envelope fusion with host cell membrane|viral envelope fusion with host membrane|viral envelope fusion with host plasma membrane|viral penetration via membrane fusion|viral-cell fusion molecule activity http://purl.obolibrary.org/obo/GO_0019064 GO:0019061 biolink:BiologicalProcess uncoating of virus The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome. go.json viral uncoating http://purl.obolibrary.org/obo/GO_0019061 GO:0019062 biolink:BiologicalProcess virion attachment to host cell The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection. VZ:956 go.json viral absorption|viral attachment to host cell|virion attachment to host cell surface receptor http://purl.obolibrary.org/obo/GO_0019062 GO:0019060 biolink:BiologicalProcess intracellular transport of viral protein in host cell The directed movement of a viral protein within the host cell. go.json cytoplasmic viral capsid transport|intracellular transport of viral capsid in host cell|intracellular transport of viral capsid protein in host cell|intracellular transport of viral proteins in host cell|intracellular viral capsid transport|intracellular viral protein transport|nuclear viral capsid transport|viral capsid transport in host cell cytoplasm|viral capsid transport in host cell nucleus http://purl.obolibrary.org/obo/GO_0019060 GO:0034693 biolink:CellularComponent U11/U12 snRNP A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins. go.json 18S U11/U12 snRNP|snRNP U11/U12 http://purl.obolibrary.org/obo/GO_0034693 GO:0034694 biolink:BiologicalProcess response to prostaglandin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. go.json response to prostaglandin stimulus http://purl.obolibrary.org/obo/GO_0034694 GO:0034695 biolink:BiologicalProcess response to prostaglandin E Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. go.json response to prostaglandin E stimulus http://purl.obolibrary.org/obo/GO_0034695 GO:0034696 biolink:BiologicalProcess response to prostaglandin F Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus. go.json response to prostaglandin F stimulus http://purl.obolibrary.org/obo/GO_0034696 GO:0034697 biolink:BiologicalProcess response to prostaglandin I Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus. go.json response to prostaglandin I stimulus http://purl.obolibrary.org/obo/GO_0034697 GO:0034698 biolink:BiologicalProcess response to gonadotropin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. go.json response to gonadotropin stimulus http://purl.obolibrary.org/obo/GO_0034698 GO:0034699 biolink:BiologicalProcess response to luteinizing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. go.json response to luteinizing hormone stimulus http://purl.obolibrary.org/obo/GO_0034699 GO:0019058 biolink:BiologicalProcess viral life cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. go.json lytic viral life cycle|viral assembly, maturation, egress, and release|viral infectious cycle|viral replication http://purl.obolibrary.org/obo/GO_0019058 GO:0019059 biolink:BiologicalProcess obsolete initiation of viral infection OBSOLETE. The set of processes involved in the start of virus infection of cells. go.json initiation of viral infection True http://purl.obolibrary.org/obo/GO_0019059 GO:0019056 biolink:BiologicalProcess modulation by virus of host transcription Any process in which a virus modulates the frequency, rate or extent of its host's transcription. go.json modification by virus of host transcription|viral perturbation of host cell transcription http://purl.obolibrary.org/obo/GO_0019056 GO:0019057 biolink:BiologicalProcess modulation by virus of host translation Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA. go.json host cell protein synthesis shutoff|host cell shutoff|modification by virus of host cell mRNA translation|modulation of host translation by virus|regulation of host mRNA translation by virus|regulation of host translation by virus|regulation of translation in host by virus|viral host shutoff protein|viral perturbation of host cell mRNA translation http://purl.obolibrary.org/obo/GO_0019057 GO:0034690 biolink:CellularComponent integrin alphaD-beta2 complex An integrin complex that comprises one alphaD subunit and one beta2 subunit. go.json Itgad-Itgb2 complex|alphaD-beta2 integrin complex http://purl.obolibrary.org/obo/GO_0034690 GO:0019054 biolink:BiologicalProcess modulation by virus of host cellular process The process in which a virus effects a change in the processes and activities of its host organism. go.json modification by virus of host cellular process|modulation by virus of host process|modulation of cellular process in host by virus|regulation by virus of host cellular process|regulation of cellular process in host by virus|regulation of host cellular process by virus|viral host cell process manipulation http://purl.obolibrary.org/obo/GO_0019054 GO:0034691 biolink:CellularComponent integrin alphaE-beta7 complex An integrin complex that comprises one alphaE subunit and one beta7 subunit. go.json Itgae-Itgb7 complex http://purl.obolibrary.org/obo/GO_0034691 GO:0034692 biolink:CellularComponent E.F.G complex A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex. go.json http://purl.obolibrary.org/obo/GO_0034692 GO:0019055 biolink:BiologicalProcess perturbation by virus of host cell cycle regulation Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication. go.json modification by virus of host cell cycle regulation|viral perturbation of cell cycle regulation http://purl.obolibrary.org/obo/GO_0019055 GO:0019074 biolink:BiologicalProcess viral RNA genome packaging The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid. go.json http://purl.obolibrary.org/obo/GO_0019074 GO:0019075 biolink:BiologicalProcess virus maturation The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release. go.json bacteriophage maturation|viral maturation http://purl.obolibrary.org/obo/GO_0019075 GO:0019072 biolink:BiologicalProcess viral genome packaging The encapsulation of the viral genome within the capsid. go.json http://purl.obolibrary.org/obo/GO_0019072 GO:0019073 biolink:BiologicalProcess viral DNA genome packaging The packing of viral DNA into a capsid. go.json http://purl.obolibrary.org/obo/GO_0019073 GO:0019070 biolink:BiologicalProcess viral genome maturation The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes. go.json http://purl.obolibrary.org/obo/GO_0019070 GO:0019071 biolink:BiologicalProcess viral DNA cleavage involved in viral genome maturation The cleavage of viral DNA into singular functional units. go.json http://purl.obolibrary.org/obo/GO_0019071 GO:0034682 biolink:CellularComponent integrin alphav-beta1 complex An integrin complex that comprises one alphav subunit and one beta1 subunit. go.json ITGAV-ITGB1 complex|alphav-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034682 GO:0034683 biolink:CellularComponent integrin alphav-beta3 complex An integrin complex that comprises one alphav subunit and one beta3 subunit. go.json ITGAV-ITGB3 complex|alphav-beta3 integrin complex http://purl.obolibrary.org/obo/GO_0034683 GO:0034684 biolink:CellularComponent integrin alphav-beta5 complex An integrin complex that comprises one alphav subunit and one beta5 subunit. go.json ITGAV-ITGB5 complex|alphav-beta5 integrin complex http://purl.obolibrary.org/obo/GO_0034684 GO:0034685 biolink:CellularComponent integrin alphav-beta6 complex An integrin complex that comprises one alphav subunit and one beta6 subunit. go.json ITGAV-ITGB6 complex|alphav-beta6 integrin complex http://purl.obolibrary.org/obo/GO_0034685 GO:0034686 biolink:CellularComponent integrin alphav-beta8 complex An integrin complex that comprises one alphav subunit and one beta8 subunit. go.json ITGAV-ITGB8 complex|alphav-beta8 integrin complex http://purl.obolibrary.org/obo/GO_0034686 GO:0034687 biolink:CellularComponent integrin alphaL-beta2 complex An integrin complex that comprises one alphaL subunit and one beta2 subunit. go.json Itgal-Itgb2 complex|alphaL-beta2 integrin complex http://purl.obolibrary.org/obo/GO_0034687 GO:0034688 biolink:CellularComponent integrin alphaM-beta2 complex An integrin complex that comprises one alphaM subunit and one beta2 subunit. go.json Itgam-Itgb2 complex|alphaM-beta2 integrin complex http://purl.obolibrary.org/obo/GO_0034688 GO:0034689 biolink:CellularComponent integrin alphaX-beta2 complex An integrin complex that comprises one alphaX subunit and one beta2 subunit. go.json Itgax-Itgb2 complex|alphaX-beta2 integrin complex http://purl.obolibrary.org/obo/GO_0034689 GO:0019069 biolink:BiologicalProcess viral capsid assembly The assembly of a virus capsid from its protein subunits. go.json http://purl.obolibrary.org/obo/GO_0019069 GO:0019067 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019067 GO:0019068 biolink:BiologicalProcess virion assembly A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. go.json bacteriophage assembly|phage assembly|viral assembly|viral particle assembly|virion assembly and maintenance|virion organization|virus assembly|virus particle assembly http://purl.obolibrary.org/obo/GO_0019068 GO:0019065 biolink:BiologicalProcess receptor-mediated endocytosis of virus by host cell Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell. go.json receptor mediated endocytosis by host of virus particle|receptor mediated endocytosis of virus by host|receptor mediated endocytosis of virus particle by host|receptor-mediated endocytosis of virus by host|viral entry into host cell via receptor-mediated endocytosis|viral receptor mediated endocytosis|virus receptor-mediated endocytosis by host http://purl.obolibrary.org/obo/GO_0019065 GO:0034680 biolink:CellularComponent integrin alpha10-beta1 complex An integrin complex that comprises one alpha10 subunit and one beta1 subunit. go.json ITGA10-ITGB1 complex|alpha10-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034680 GO:0034681 biolink:CellularComponent integrin alpha11-beta1 complex An integrin complex that comprises one alpha11 subunit and one beta1 subunit. go.json ITGA11-ITGB1 complex|alpha11-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034681 GO:0019066 biolink:BiologicalProcess obsolete translocation of virus into host cell OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane. go.json translocation of virus into host cell|viral translocation True http://purl.obolibrary.org/obo/GO_0019066 GO:0020030 biolink:CellularComponent infected host cell surface knob Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species. go.json http://purl.obolibrary.org/obo/GO_0020030 GO:0019041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019041 GO:0019042 biolink:BiologicalProcess viral latency The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. go.json latent virus infection|phage lysogeny|viral dormancy http://purl.obolibrary.org/obo/GO_0019042 GO:0020031 biolink:CellularComponent polar ring of apical complex An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite. go.json anterior polar ring of apical complex|upper polar ring of apical complex http://purl.obolibrary.org/obo/GO_0020031 GO:0020032 biolink:CellularComponent basal ring of apical complex An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite. go.json lower polar ring of apical complex|posterior polar ring of apical complex|preconoidal ring of apical complex http://purl.obolibrary.org/obo/GO_0020032 GO:0020033 biolink:BiologicalProcess antigenic variation Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system. Wikipedia:Antigenic_variation go.json surface antigen variation http://purl.obolibrary.org/obo/GO_0020033 GO:0019040 biolink:MolecularActivity obsolete viral host shutoff protein OBSOLETE. (Was not defined before being made obsolete). go.json viral host shutoff protein True http://purl.obolibrary.org/obo/GO_0019040 GO:0020034 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0020034 GO:0020035 biolink:BiologicalProcess adhesion of symbiont to microvasculature The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte. go.json cytoadherence to microvasculature, mediated by parasite protein|cytoadherence to microvasculature, mediated by symbiont protein|heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein|parasite-protein-mediated cytoadherence to microvasculature|symbiont-protein-mediated cytoadherence to microvasculature http://purl.obolibrary.org/obo/GO_0020035 GO:0020036 biolink:CellularComponent Maurer's cleft A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton. go.json Maurers cleft http://purl.obolibrary.org/obo/GO_0020036 GO:0020037 biolink:MolecularActivity heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. go.json haem binding http://purl.obolibrary.org/obo/GO_0020037 GO:0034679 biolink:CellularComponent integrin alpha9-beta1 complex An integrin complex that comprises one alpha9 subunit and one beta1 subunit. go.json ITGA9-ITGB1 complex|alpha9-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034679 GO:0034671 biolink:BiologicalProcess retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros. go.json retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification|retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning http://purl.obolibrary.org/obo/GO_0034671 GO:0034672 biolink:BiologicalProcess anterior/posterior pattern specification involved in pronephros development The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. go.json anterior/posterior pattern specification involved in pronephric kidney development http://purl.obolibrary.org/obo/GO_0034672 GO:0034673 biolink:CellularComponent inhibin-betaglycan-ActRII complex A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B. go.json http://purl.obolibrary.org/obo/GO_0034673 GO:0034674 biolink:CellularComponent integrin alpha5-beta1 complex An integrin complex that comprises one alpha5 subunit and one beta1 subunit. go.json ITGA5-ITGB1 complex|VLA-5 complex|alpha5-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034674 GO:0034675 biolink:CellularComponent integrin alpha6-beta1 complex An integrin complex that comprises one alpha6 subunit and one beta1 subunit. go.json ITGA6-ITGB1 complex|VLA-6 complex|alpha6-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034675 GO:0034676 biolink:CellularComponent integrin alpha6-beta4 complex An integrin complex that comprises one alpha6 subunit and one beta4 subunit. go.json ITGA6-ITGB4 complex|alpha6-beta4 integrin complex http://purl.obolibrary.org/obo/GO_0034676 GO:0034677 biolink:CellularComponent integrin alpha7-beta1 complex An integrin complex that comprises one alpha7 subunit and one beta1 subunit. go.json ITGA7-ITGB1 complex|alpha7-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034677 GO:0034678 biolink:CellularComponent integrin alpha8-beta1 complex An integrin complex that comprises one alpha8 subunit and one beta1 subunit. go.json ITGA8-ITGB1 complex|alpha8-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034678 GO:0019038 biolink:CellularComponent obsolete provirus OBSOLETE. The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle. Wikipedia:Provirus go.json True http://purl.obolibrary.org/obo/GO_0019038 GO:0020038 biolink:CellularComponent subpellicular network A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0020038 GO:0020039 biolink:CellularComponent pellicle The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles. go.json http://purl.obolibrary.org/obo/GO_0020039 GO:0019039 biolink:MolecularActivity obsolete viral-cell fusion molecule activity OBSOLETE. (Was not defined before being made obsolete). go.json viral-cell fusion molecule activity True http://purl.obolibrary.org/obo/GO_0019039 GO:0019036 biolink:CellularComponent viral transcriptional complex Specific locations and structures in the virus infected cell involved in transcribing the viral genome. go.json http://purl.obolibrary.org/obo/GO_0019036 GO:0019037 biolink:CellularComponent obsolete viral assembly intermediate OBSOLETE. Specific locations and structures in the virus infected cell involved in assembling new virions. go.json True http://purl.obolibrary.org/obo/GO_0019037 GO:0019034 biolink:CellularComponent viral replication complex Specific locations and structures in the virus infected cell involved in replicating the viral genome. go.json http://purl.obolibrary.org/obo/GO_0019034 GO:0019035 biolink:CellularComponent viral integration complex A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins. Wikipedia:Pre-integration_complex go.json PIC|pre-integration complex http://purl.obolibrary.org/obo/GO_0019035 GO:0019032 biolink:CellularComponent obsolete viral glycoprotein OBSOLETE. (Was not defined before being made obsolete). go.json viral glycoprotein True http://purl.obolibrary.org/obo/GO_0019032 GO:0034670 biolink:BiologicalProcess chemotaxis to arachidonic acid The directed movement of a motile cell or organism in response to the presence of arachidonic acid. go.json http://purl.obolibrary.org/obo/GO_0034670 GO:0019033 biolink:CellularComponent viral tegument A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically. Wikipedia:Viral_tegument go.json http://purl.obolibrary.org/obo/GO_0019033 GO:0019052 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019052 GO:0019053 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019053 GO:0020020 biolink:CellularComponent food vacuole Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa. go.json digestive vacuole http://purl.obolibrary.org/obo/GO_0020020 GO:0020021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0020021 GO:0019050 biolink:BiologicalProcess suppression by virus of host apoptotic process A process in which a virus gene product suppresses host apoptosis, leading to a decrease in the frequency, rate or extent of apoptosis in the host cell. go.json inhibition of host caspases by virus|negative regulation by virus of host apoptosis|negative regulation of apoptosis by virus|suppression by virus of host apoptosis|suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process|suppression of apoptosis in host by virus http://purl.obolibrary.org/obo/GO_0019050 GO:0019051 biolink:BiologicalProcess induction by virus of host apoptotic process A process in which a viral gene product activates host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. go.json activation by virus of host apoptosis|activation by virus of host apoptotic programmed cell death|activation of apoptosis in host by virus|activation of host caspases by virus|induction by virus of host apoptosis|induction by virus of host apoptotic programmed cell death|induction by virus of host caspase activity|induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process|induction of apoptosis in host by virus|positive regulation of apoptosis by virus|positive regulation of apoptotic process by virus http://purl.obolibrary.org/obo/GO_0019051 GO:0020022 biolink:CellularComponent acidocalcisome An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. go.json metachromatic granule|polyphosphate vacuole|volutin granule http://purl.obolibrary.org/obo/GO_0020022 goslim_pir GO:0020023 biolink:CellularComponent kinetoplast A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum. Wikipedia:Kinetoplast go.json http://purl.obolibrary.org/obo/GO_0020023 GO:0020025 biolink:CellularComponent subpellicular microtubule Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid. go.json http://purl.obolibrary.org/obo/GO_0020025 GO:0020026 biolink:CellularComponent merozoite dense granule Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell. go.json dense body http://purl.obolibrary.org/obo/GO_0020026 GO:0034668 biolink:CellularComponent integrin alpha4-beta1 complex An integrin complex that comprises one alpha4 subunit and one beta1 subunit. go.json ITGA4-ITGB1 complex|VLA-4 complex|alpha4-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034668 GO:0034669 biolink:CellularComponent integrin alpha4-beta7 complex An integrin complex that comprises one alpha4 subunit and one beta7 subunit. go.json ITGA4-ITGB7 complex|alpha4-beta7 integrin complex http://purl.obolibrary.org/obo/GO_0034669 GO:0034660 biolink:BiologicalProcess ncRNA metabolic process The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). go.json ncRNA metabolism http://purl.obolibrary.org/obo/GO_0034660 GO:0034661 biolink:BiologicalProcess ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). go.json ncRNA breakdown|ncRNA catabolism|ncRNA degradation http://purl.obolibrary.org/obo/GO_0034661 GO:0034662 biolink:CellularComponent CFTR-NHERF-ezrin complex A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity. go.json http://purl.obolibrary.org/obo/GO_0034662 GO:0034663 biolink:CellularComponent endoplasmic reticulum chaperone complex A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. go.json ER chaperone complex|ER network complex|endoplasmic reticulum network complex http://purl.obolibrary.org/obo/GO_0034663 GO:0034664 biolink:CellularComponent Ig heavy chain-bound endoplasmic reticulum chaperone complex A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. go.json Ig heavy chain-bound ER chaperone complex|immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex http://purl.obolibrary.org/obo/GO_0034664 GO:0034665 biolink:CellularComponent integrin alpha1-beta1 complex An integrin complex that comprises one alpha1 subunit and one beta1 subunit. go.json ITGA1-ITGB1 complex|VLA-1 complex|alpha1-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034665 GO:0034666 biolink:CellularComponent integrin alpha2-beta1 complex An integrin complex that comprises one alpha2 subunit and one beta1 subunit. go.json ITGA2-ITGB1 complex|VLA-2 complex http://purl.obolibrary.org/obo/GO_0034666 GO:0034667 biolink:CellularComponent integrin alpha3-beta1 complex An integrin complex that comprises one alpha3 subunit and one beta1 subunit. go.json ITGA3-ITGB1 complex|VLA-3 complex|alpha3-beta1 integrin complex http://purl.obolibrary.org/obo/GO_0034667 GO:0019049 biolink:BiologicalProcess virus-mediated perturbation of host defense response A process in which a virus interferes with the ability of the host to mount a defense in response to its presence. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json evasion of host defenses by virus|mitigation of host antiviral defense response|mitigation of host defenses by virus|perturbation of host defense response by virus|regulation by virus of antiviral response|regulation of defense response to virus by virus|viral host defence evasion|viral host defense evasion|viral regulation of antiviral response http://purl.obolibrary.org/obo/GO_0019049 GO:0020027 biolink:BiologicalProcess hemoglobin metabolic process The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. go.json haemoglobin metabolic process|haemoglobin metabolism|hemoglobin metabolism http://purl.obolibrary.org/obo/GO_0020027 GO:0020028 biolink:BiologicalProcess endocytic hemoglobin import into cell The directed movement of hemoglobin into a cell by receptor-mediated endocytosis. go.json endocytic hemoglobin import|haemoglobin uptake|hemoglobin uptake http://purl.obolibrary.org/obo/GO_0020028 GO:0020029 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0020029 GO:0019047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019047 GO:0019048 biolink:BiologicalProcess modulation by virus of host process The process in which a virus effects a change in the structure or processes of its host organism. VZ:886 go.json disruption by virus of host cell|host-virus interaction|modulation by virus of host anatomical structure or process|modulation by virus of host anatomy or process|modulation by virus of host morphology or physiology|viral interaction with host|viral-host process|virus-host interaction|virus-host process http://purl.obolibrary.org/obo/GO_0019048 GO:0019045 biolink:BiologicalProcess latent virus replication Any process required for latent viral replication in a cell. go.json http://purl.obolibrary.org/obo/GO_0019045 GO:0019046 biolink:BiologicalProcess release from viral latency The process by which a virus begins to replicate following a latency replication decision (switch). go.json http://purl.obolibrary.org/obo/GO_0019046 GO:0019043 biolink:BiologicalProcess establishment of viral latency A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects. go.json lysogenic commitment|phage lysogeny http://purl.obolibrary.org/obo/GO_0019043 GO:0019044 biolink:BiologicalProcess maintenance of viral latency The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms. go.json latent virus maintenance|prophage maintenance|provirus maintenance http://purl.obolibrary.org/obo/GO_0019044 GO:0019020 biolink:CellularComponent obsolete multipartite viral genome OBSOLETE. A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion. go.json True http://purl.obolibrary.org/obo/GO_0019020 GO:0020010 biolink:CellularComponent conoid A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules. go.json http://purl.obolibrary.org/obo/GO_0020010 GO:0020011 biolink:CellularComponent apicoplast The plastid organelle found in apicomplexans. Wikipedia:Apicoplast go.json http://purl.obolibrary.org/obo/GO_0020011 GO:0020012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0020012 GO:0020013 biolink:BiologicalProcess modulation by symbiont of host erythrocyte aggregation Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes. Wikipedia:Rosetting go.json rosetting http://purl.obolibrary.org/obo/GO_0020013 GO:0020014 biolink:BiologicalProcess schizogony Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously. Wikipedia:Protozoal_merogony go.json http://purl.obolibrary.org/obo/GO_0020014 GO:0020015 biolink:CellularComponent glycosome A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. Wikipedia:Glycosome go.json http://purl.obolibrary.org/obo/GO_0020015 goslim_pir GO:0034657 biolink:CellularComponent GID complex A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species. go.json C-terminal to LisH complex|CTLH complex http://purl.obolibrary.org/obo/GO_0034657 GO:0034658 biolink:MolecularActivity isopropylmalate transmembrane transporter activity Enables the transfer of isopropylmalate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0034658 GO:0010688 biolink:BiologicalProcess negative regulation of ribosomal protein gene transcription by RNA polymerase II Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. go.json negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0010688 GO:0034659 biolink:BiologicalProcess isopropylmalate transport The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0034659 GO:0010689 biolink:BiologicalProcess negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus. go.json http://purl.obolibrary.org/obo/GO_0010689 GO:0009693 biolink:BiologicalProcess ethylene biosynthetic process The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. MetaCyc:ETHYL-PWY go.json ethene biosynthesis|ethene biosynthesis from L-methionine|ethene biosynthetic process|ethene biosynthetic process from L-methionine|ethylene anabolism|ethylene biosynthesis|ethylene biosynthesis from L-methionine|ethylene biosynthetic process from L-methionine|ethylene formation|ethylene synthesis http://purl.obolibrary.org/obo/GO_0009693 GO:0010682 biolink:BiologicalProcess obsolete cinnamic acid biosynthetic process involved in flavonoid metabolism OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids. go.json True http://purl.obolibrary.org/obo/GO_0010682 GO:0034650 biolink:BiologicalProcess cortisol metabolic process The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. go.json cortisol metabolism http://purl.obolibrary.org/obo/GO_0034650 GO:0010683 biolink:BiologicalProcess tricyclic triterpenoid metabolic process The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings. go.json tricyclic triterpenoid metabolism http://purl.obolibrary.org/obo/GO_0010683 GO:0009694 biolink:BiologicalProcess jasmonic acid metabolic process The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid. go.json jasmonic acid metabolism http://purl.obolibrary.org/obo/GO_0009694 GO:0034651 biolink:BiologicalProcess cortisol biosynthetic process The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. go.json cortisol anabolism|cortisol biosynthesis|cortisol formation|cortisol synthesis http://purl.obolibrary.org/obo/GO_0034651 GO:0009695 biolink:BiologicalProcess jasmonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative. MetaCyc:PWY-735 go.json jasmonic acid anabolism|jasmonic acid biosynthesis|jasmonic acid formation|jasmonic acid synthesis http://purl.obolibrary.org/obo/GO_0009695 GO:0010680 biolink:BiologicalProcess obsolete cinnamic acid biosynthetic process involved in coumarin metabolism OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin. go.json True http://purl.obolibrary.org/obo/GO_0010680 GO:0034652 biolink:BiologicalProcess obsolete extrachromosomal circular DNA localization involved in cell aging OBSOLETE. A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging. go.json extrachromosomal circular DNA localisation involved in cell aging|extrachromosomal circular DNA localization during cell ageing|extrachromosomal circular DNA localization during cell aging True http://purl.obolibrary.org/obo/GO_0034652 GO:0009696 biolink:BiologicalProcess salicylic acid metabolic process The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. go.json salicylic acid metabolism http://purl.obolibrary.org/obo/GO_0009696 GO:0010681 biolink:BiologicalProcess obsolete cinnamic acid biosynthetic process involved in stilbene metabolism OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene. go.json True http://purl.obolibrary.org/obo/GO_0010681 GO:0009697 biolink:BiologicalProcess salicylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. MetaCyc:PWY-981 go.json salicylate biosynthetic process|salicylic acid anabolism|salicylic acid biosynthesis|salicylic acid formation|salicylic acid synthesis http://purl.obolibrary.org/obo/GO_0009697 GO:0034653 biolink:BiologicalProcess retinoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A. go.json retinoic acid breakdown|retinoic acid catabolism|retinoic acid degradation|vitamin A1 acid catabolic process http://purl.obolibrary.org/obo/GO_0034653 GO:0010686 biolink:BiologicalProcess tetracyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings. go.json tetracyclic triterpenoid biosynthesis http://purl.obolibrary.org/obo/GO_0010686 GO:0010687 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010687 GO:0009698 biolink:BiologicalProcess phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. MetaCyc:PWY1F-467 go.json phenylpropanoid metabolism http://purl.obolibrary.org/obo/GO_0009698 GO:0034654 biolink:BiologicalProcess nucleobase-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. go.json nucleobase, nucleoside, nucleotide and nucleic acid anabolism|nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis|nucleobase, nucleoside, nucleotide and nucleic acid formation|nucleobase, nucleoside, nucleotide and nucleic acid synthesis http://purl.obolibrary.org/obo/GO_0034654 GO:0009699 biolink:BiologicalProcess phenylpropanoid biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid. go.json phenylpropanoid anabolism|phenylpropanoid biosynthesis|phenylpropanoid formation|phenylpropanoid synthesis http://purl.obolibrary.org/obo/GO_0009699 GO:0010684 biolink:BiologicalProcess tricyclic triterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings. go.json tricyclic triterpenoid catabolism http://purl.obolibrary.org/obo/GO_0010684 GO:0019018 biolink:CellularComponent obsolete bipartite viral genome OBSOLETE. A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion. go.json True http://purl.obolibrary.org/obo/GO_0019018 GO:0034655 biolink:BiologicalProcess nucleobase-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. go.json nucleobase, nucleoside, nucleotide and nucleic acid breakdown|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process|nucleobase, nucleoside, nucleotide and nucleic acid catabolism|nucleobase, nucleoside, nucleotide and nucleic acid degradation http://purl.obolibrary.org/obo/GO_0034655 goslim_chembl GO:0034656 biolink:BiologicalProcess nucleobase-containing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. go.json nucleobase, nucleoside and nucleotide breakdown|nucleobase, nucleoside and nucleotide catabolism|nucleobase, nucleoside and nucleotide degradation http://purl.obolibrary.org/obo/GO_0034656 GO:0019019 biolink:CellularComponent obsolete tripartite viral genome OBSOLETE. A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion. go.json True http://purl.obolibrary.org/obo/GO_0019019 GO:0010685 biolink:BiologicalProcess tetracyclic triterpenoid metabolic process The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings. go.json tetracyclic triterpenoid metabolism http://purl.obolibrary.org/obo/GO_0010685 GO:0019016 biolink:CellularComponent obsolete non-segmented viral genome OBSOLETE. A viral genome that consists of one continuous nucleic acid molecule. go.json True http://purl.obolibrary.org/obo/GO_0019016 GO:0020016 biolink:CellularComponent ciliary pocket Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes. go.json cilial pocket|cilium pocket|flagellar pocket http://purl.obolibrary.org/obo/GO_0020016 GO:0019017 biolink:CellularComponent obsolete segmented viral genome OBSOLETE. A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion. go.json True http://purl.obolibrary.org/obo/GO_0019017 GO:0020017 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0020017 GO:0020018 biolink:CellularComponent ciliary pocket membrane That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket). go.json cilial pocket membrane|cilium pocket membrane|flagellar pocket membrane http://purl.obolibrary.org/obo/GO_0020018 GO:0019014 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019014 GO:0019015 biolink:CellularComponent obsolete viral genome OBSOLETE. The whole of the genetic information of a virus, contained as either DNA or RNA. go.json True http://purl.obolibrary.org/obo/GO_0019015 GO:0019012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019012 GO:0019013 biolink:CellularComponent viral nucleocapsid The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle. go.json core|nucleocapsid http://purl.obolibrary.org/obo/GO_0019013 goslim_chembl GO:0019010 biolink:MolecularActivity farnesoic acid O-methyltransferase activity Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine. go.json S-adenosyl-methionine:farnesoic acid O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0019010 GO:0019011 biolink:MolecularActivity obsolete DNA replication accessory factor OBSOLETE. (Was not defined before being made obsolete). go.json DNA replication accessory factor True http://purl.obolibrary.org/obo/GO_0019011 GO:0019030 biolink:CellularComponent icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure. go.json quasispherical viral capsid http://purl.obolibrary.org/obo/GO_0019030 GO:0019031 biolink:CellularComponent viral envelope The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins. Wikipedia:Viral_envelope go.json viral glycoprotein|viral outside membrane http://purl.obolibrary.org/obo/GO_0019031 goslim_chembl GO:0020002 biolink:CellularComponent host cell plasma membrane The plasma membrane surrounding a host cell. go.json http://purl.obolibrary.org/obo/GO_0020002 GO:0020003 biolink:CellularComponent symbiont-containing vacuole Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont. go.json SCV|Salmonella-containing vacuole|bacterium-containing vacuole|parasitophorous vacuole|pathogen-occupied vacuole http://purl.obolibrary.org/obo/GO_0020003 GO:0020004 biolink:CellularComponent symbiont-containing vacuolar space The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane. go.json parasitophorous vacuolar space|symbiont-containing vacuole space http://purl.obolibrary.org/obo/GO_0020004 GO:0034646 biolink:CellularComponent organelle-enclosing lipid monolayer A lipid monolayer that surrounds and encloses an organelle. go.json http://purl.obolibrary.org/obo/GO_0034646 GO:0034647 biolink:MolecularActivity histone H3K4me/H3K4me2/H3K4me3 demethylase activity Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. EC:1.14.11.67|RHEA:60208 go.json H3K4me3 demethylase activity|histone H3-K4me2 demethylase activity|histone H3-K4me3 demethylase activity|histone H3-tri/di/monomethyl-lysine-4 demethylase activity|histone H3K4me2 demethylase activity|histone demethylase activity (H3-K4-me3 specific)|histone demethylase activity (H3-trimethyl-K4 specific) http://purl.obolibrary.org/obo/GO_0034647 GO:0034648 biolink:MolecularActivity obsolete histone demethylase activity (H3-dimethyl-K4 specific) OBSOLETE. Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein. go.json histone demethylase activity (H3-K4-me2 specific) True http://purl.obolibrary.org/obo/GO_0034648 GO:0010699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010699 GO:0034649 biolink:MolecularActivity obsolete histone demethylase activity (H3-monomethyl-K4 specific) OBSOLETE. Catalysis of the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein. go.json histone demethylase activity (H3-K4-me1 specific) True http://purl.obolibrary.org/obo/GO_0034649 GO:0010693 biolink:BiologicalProcess negative regulation of alkaline phosphatase activity Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. go.json http://purl.obolibrary.org/obo/GO_0010693 gocheck_do_not_annotate GO:0010694 biolink:BiologicalProcess positive regulation of alkaline phosphatase activity Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. go.json http://purl.obolibrary.org/obo/GO_0010694 gocheck_do_not_annotate GO:0034640 biolink:BiologicalProcess establishment of mitochondrion localization by microtubule attachment The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization. go.json establishment of mitochondrion localisation by microtubule attachment|mitochondrial localization by microtubule attachment|mitochondrial migration by microtubule attachment|mitochondrion migration by microtubule attachment http://purl.obolibrary.org/obo/GO_0034640 GO:0010691 biolink:BiologicalProcess negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. go.json http://purl.obolibrary.org/obo/GO_0010691 GO:0010692 biolink:BiologicalProcess regulation of alkaline phosphatase activity Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. go.json http://purl.obolibrary.org/obo/GO_0010692 gocheck_do_not_annotate GO:0034641 biolink:BiologicalProcess cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. go.json cellular nitrogen compound metabolism http://purl.obolibrary.org/obo/GO_0034641 goslim_chembl GO:0010697 biolink:BiologicalProcess negative regulation of mitotic spindle pole body separation Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. go.json negative regulation of SPB separation http://purl.obolibrary.org/obo/GO_0010697 GO:0034642 biolink:BiologicalProcess mitochondrion migration along actin filament The directed movement of a mitochondrion along a microfilament, mediated by motor proteins. go.json mitochondrial migration along actin filament|mitochondrial migration along microfilament|mitochondrial migration, actin-mediated|mitochondrion migration along microfilament|mitochondrion transport along actin filament http://purl.obolibrary.org/obo/GO_0034642 GO:0010698 biolink:MolecularActivity acetyltransferase activator activity Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. go.json acetyltransferase stimulator activity http://purl.obolibrary.org/obo/GO_0010698 GO:0034643 biolink:BiologicalProcess establishment of mitochondrion localization, microtubule-mediated The directed movement of the mitochondrion to a specific location, by a process involving microtubules. go.json establishment of mitochondrion localisation, microtubule-mediated|microtubule-mediated mitochondrion localization|mitochondrial localization, microtubule-mediated http://purl.obolibrary.org/obo/GO_0034643 GO:0034644 biolink:BiologicalProcess cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. go.json cellular response to UV light stimulus|cellular response to UV radiation stimulus|cellular response to ultraviolet light stimulus|cellular response to ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_0034644 GO:0019029 biolink:CellularComponent helical viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure. go.json http://purl.obolibrary.org/obo/GO_0019029 GO:0010695 biolink:BiologicalProcess regulation of mitotic spindle pole body separation Any process that modulates the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. go.json regulation of SPB separation http://purl.obolibrary.org/obo/GO_0010695 GO:0034645 biolink:BiologicalProcess obsolete cellular macromolecule biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. go.json cellular biopolymer biosynthetic process|cellular macromolecule anabolism|cellular macromolecule biosynthesis|cellular macromolecule formation|cellular macromolecule synthesis True http://purl.obolibrary.org/obo/GO_0034645 GO:0010696 biolink:BiologicalProcess positive regulation of mitotic spindle pole body separation Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. go.json positive regulation of SPB separation http://purl.obolibrary.org/obo/GO_0010696 GO:0020005 biolink:CellularComponent symbiont-containing vacuole membrane The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont. go.json parasitophorous vacuolar membrane http://purl.obolibrary.org/obo/GO_0020005 GO:0019027 biolink:CellularComponent obsolete ambisense viral genome OBSOLETE. A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0019027 GO:0019028 biolink:CellularComponent viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. Wikipedia:Capsid go.json http://purl.obolibrary.org/obo/GO_0019028 goslim_chembl GO:0020006 biolink:CellularComponent symbiont-containing vacuolar membrane network Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm. go.json parasitophorous vacuolar membrane network|symbiont-containing vacuole membrane network|tubulovesicular network http://purl.obolibrary.org/obo/GO_0020006 GO:0019025 biolink:CellularComponent obsolete positive sense viral genome OBSOLETE. A single stranded RNA genome with the same nucleotide polarity as mRNA. go.json True http://purl.obolibrary.org/obo/GO_0019025 GO:0020007 biolink:CellularComponent apical complex A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation. go.json http://purl.obolibrary.org/obo/GO_0020007 GO:0020008 biolink:CellularComponent rhoptry A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole. Wikipedia:Rhoptry go.json paired organelles|toxoneme http://purl.obolibrary.org/obo/GO_0020008 GO:0019026 biolink:CellularComponent obsolete negative sense viral genome OBSOLETE. A single stranded RNA genome with the opposite nucleotide polarity as mRNA. go.json True http://purl.obolibrary.org/obo/GO_0019026 GO:0019023 biolink:CellularComponent obsolete dsRNA viral genome OBSOLETE. A viral genome composed of double stranded RNA. go.json True http://purl.obolibrary.org/obo/GO_0019023 GO:0020009 biolink:CellularComponent microneme A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell. Wikipedia:Microneme go.json sarconeme http://purl.obolibrary.org/obo/GO_0020009 GO:0019024 biolink:CellularComponent obsolete ssRNA viral genome OBSOLETE. A viral genome composed of single stranded RNA of either positive or negative sense. go.json True http://purl.obolibrary.org/obo/GO_0019024 GO:0010690 biolink:BiologicalProcess negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis. go.json http://purl.obolibrary.org/obo/GO_0010690 GO:0019021 biolink:CellularComponent obsolete DNA viral genome OBSOLETE. A viral genome composed of deoxyribonucleic acid. go.json True http://purl.obolibrary.org/obo/GO_0019021 GO:0019022 biolink:CellularComponent obsolete RNA viral genome OBSOLETE. A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked. go.json True http://purl.obolibrary.org/obo/GO_0019022 GO:0034635 biolink:BiologicalProcess glutathione transport The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0034635 GO:0010668 biolink:BiologicalProcess ectodermal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0010668 GO:0034636 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034636 GO:0010669 biolink:BiologicalProcess epithelial structure maintenance A tissue homeostatic process required for the maintenance of epithelial structure. go.json http://purl.obolibrary.org/obo/GO_0010669 GO:0034637 biolink:BiologicalProcess obsolete cellular carbohydrate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. go.json True http://purl.obolibrary.org/obo/GO_0034637 GO:0010666 biolink:BiologicalProcess positive regulation of cardiac muscle cell apoptotic process Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. go.json positive regulation of cardiac muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010666 GO:0034638 biolink:BiologicalProcess phosphatidylcholine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. go.json phosphatidylcholine breakdown|phosphatidylcholine catabolism|phosphatidylcholine degradation http://purl.obolibrary.org/obo/GO_0034638 GO:0010667 biolink:BiologicalProcess negative regulation of cardiac muscle cell apoptotic process Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. go.json down regulation of cardiac muscle cell apoptosis|down-regulation of cardiac muscle cell apoptosis|downregulation of cardiac muscle cell apoptosis|inhibition of cardiac muscle cell apoptosis|negative regulation of cardiac muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010667 GO:0034639 biolink:MolecularActivity L-amino acid efflux transmembrane transporter activity Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane. go.json L-amino acid efflux permease activity|L-amino acid export transporter activity http://purl.obolibrary.org/obo/GO_0034639 GO:0009680 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009680 GO:0009681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009681 GO:0009671 biolink:MolecularActivity nitrate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in). go.json nitrate(chlorate):hydrogen symporter activity|nitrate(chlorate):proton symporter activity|nitrate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0009671 GO:0010660 biolink:BiologicalProcess regulation of muscle cell apoptotic process Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. go.json regulation of muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010660 GO:0010661 biolink:BiologicalProcess positive regulation of muscle cell apoptotic process Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. go.json positive regulation of muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010661 GO:0009672 biolink:MolecularActivity auxin:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in). go.json auxin:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0009672 GO:0009673 biolink:MolecularActivity low-affinity phosphate transmembrane transporter activity Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity phosphate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0009673 GO:0034630 biolink:BiologicalProcess RITS complex localization Any process in which a RITS complex is transported to, or maintained in, a specific location. go.json RITS complex localisation|establishment and maintenance of RITS complex localization http://purl.obolibrary.org/obo/GO_0034630 GO:0009674 biolink:MolecularActivity potassium:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in). go.json high affinity potassium transporter http://purl.obolibrary.org/obo/GO_0009674 GO:0034631 biolink:BiologicalProcess microtubule anchoring at spindle pole body Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end. go.json attachment of spindle microtubules to SPB|attachment of spindle microtubules to spindle pole body|microtubule anchoring at SPB http://purl.obolibrary.org/obo/GO_0034631 GO:0010664 biolink:BiologicalProcess negative regulation of striated muscle cell apoptotic process Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. go.json down regulation of striated muscle cell apoptosis|down-regulation of striated muscle cell apoptosis|downregulation of striated muscle cell apoptosis|inhibition of striated muscle cell apoptosis|negative regulation of striated muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010664 GO:0009675 biolink:MolecularActivity high-affinity sulfate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity sulfate:hydrogen symporter activity|high affinity sulfate:proton symporter activity|high affinity sulphate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0009675 GO:0010665 biolink:BiologicalProcess regulation of cardiac muscle cell apoptotic process Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. go.json regulation of cardiac muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010665 GO:0009676 biolink:MolecularActivity low-affinity sulfate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity sulfate:hydrogen symporter activity|low affinity sulfate:proton symporter activity|low affinity sulphate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0009676 GO:0034632 biolink:MolecularActivity retinol transmembrane transporter activity Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Reactome:R-HSA-1467466|Reactome:R-HSA-2466749|Reactome:R-HSA-2466802 go.json retinol transporter activity|vitamin A1 transporter activity http://purl.obolibrary.org/obo/GO_0034632 GO:0034633 biolink:BiologicalProcess retinol transport The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. go.json vitamin A1 transport http://purl.obolibrary.org/obo/GO_0034633 GO:0009677 biolink:BiologicalProcess double fertilization forming two zygotes Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis. go.json http://purl.obolibrary.org/obo/GO_0009677 GO:0010662 biolink:BiologicalProcess regulation of striated muscle cell apoptotic process Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. go.json regulation of striated muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010662 GO:0009678 biolink:MolecularActivity diphosphate hydrolysis-driven proton transmembrane transporter activity Catalysis of the reaction: diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate. EC:7.1.3.1|MetaCyc:TRANS-RXN-370|RHEA:13973|TC:3.A.10 go.json H+-exporting diphosphatase|PP(i) hydrolysis-driven proton transmembrane transporter activity|hydrogen-translocating pyrophosphatase activity|proton-pumping diphosphatase|proton-pumping pyrophosphatase|proton-translocating pyrophosphatase activity|pyrophosphate hydrolysis-driven proton transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0009678 GO:0034634 biolink:MolecularActivity glutathione transmembrane transporter activity Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0034634 GO:0010663 biolink:BiologicalProcess positive regulation of striated muscle cell apoptotic process Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. go.json positive regulation of striated muscle cell apoptosis http://purl.obolibrary.org/obo/GO_0010663 GO:0009679 biolink:MolecularActivity hexose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in). go.json hexose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0009679 GO:0034624 biolink:BiologicalProcess obsolete DNA recombinase assembly involved in gene conversion at mating-type locus OBSOLETE. The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another. go.json True http://purl.obolibrary.org/obo/GO_0034624 GO:0010679 biolink:BiologicalProcess obsolete cinnamic acid biosynthetic process involved in salicylic acid metabolism OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid. go.json True http://purl.obolibrary.org/obo/GO_0010679 GO:0034625 biolink:BiologicalProcess fatty acid elongation, monounsaturated fatty acid Elongation of a fatty acid chain into which one C-C double bond has been introduced. go.json http://purl.obolibrary.org/obo/GO_0034625 GO:0034626 biolink:BiologicalProcess fatty acid elongation, polyunsaturated fatty acid Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced. go.json http://purl.obolibrary.org/obo/GO_0034626 GO:0010677 biolink:BiologicalProcess obsolete negative regulation of cellular carbohydrate metabolic process OBSOLETE. Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. go.json True http://purl.obolibrary.org/obo/GO_0010677 GO:0010678 biolink:BiologicalProcess obsolete negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated OBSOLETE. Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription. go.json negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent|negative regulation of cellular carbohydrate metabolic process by repression of transcription|negative regulation of cellular carbohydrate metabolic process by transcriptional repression True http://purl.obolibrary.org/obo/GO_0010678 GO:0034627 biolink:BiologicalProcess 'de novo' NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. go.json de novo NAD biosynthetic process http://purl.obolibrary.org/obo/GO_0034627 GO:0034628 biolink:BiologicalProcess 'de novo' NAD biosynthetic process from aspartate The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. go.json de novo NAD biosynthetic process from aspartate|nicotinamide nucleotide anabolism from aspartate|nicotinamide nucleotide biosynthetic process from aspartate|nicotinamide nucleotide formation from aspartate|nicotinamide nucleotide synthesis from aspartate http://purl.obolibrary.org/obo/GO_0034628 GO:0034629 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034629 GO:0009690 biolink:BiologicalProcess cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. go.json cytokinin metabolism http://purl.obolibrary.org/obo/GO_0009690 goslim_chembl GO:0009691 biolink:BiologicalProcess cytokinin biosynthetic process The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. go.json cytokinin anabolism|cytokinin biosynthesis|cytokinin formation|cytokinin synthesis http://purl.obolibrary.org/obo/GO_0009691 GO:0009692 biolink:BiologicalProcess ethylene metabolic process The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. go.json ethene metabolic process|ethene metabolism|ethylene metabolism http://purl.obolibrary.org/obo/GO_0009692 GO:0009682 biolink:BiologicalProcess induced systemic resistance A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling. go.json http://purl.obolibrary.org/obo/GO_0009682 GO:0010671 biolink:BiologicalProcess obsolete negative regulation of oxygen and reactive oxygen species metabolic process OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH). go.json negative regulation of oxygen and reactive oxygen species metabolic process True http://purl.obolibrary.org/obo/GO_0010671 GO:0010672 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. go.json regulation of meiosis by regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter, meiotic True http://purl.obolibrary.org/obo/GO_0010672 GO:0009683 biolink:BiologicalProcess indoleacetic acid metabolic process The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants. go.json IAA metabolic process|indole acetic acid metabolic process|indole acetic acid metabolism|indoleacetic acid metabolism http://purl.obolibrary.org/obo/GO_0009683 GO:0009684 biolink:BiologicalProcess indoleacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants. go.json IAA biosynthetic process|indole acetic acid biosynthesis|indole acetic acid biosynthetic process|indole-3-acetate biosynthesis|indole-3-acetate biosynthetic process|indole-acetic acid biosynthesis|indole-acetic acid biosynthetic process|indoleacetic acid anabolism|indoleacetic acid biosynthesis|indoleacetic acid formation|indoleacetic acid synthesis http://purl.obolibrary.org/obo/GO_0009684 GO:0010670 biolink:BiologicalProcess obsolete positive regulation of oxygen and reactive oxygen species metabolic process OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH). go.json positive regulation of oxygen and reactive oxygen species metabolic process True http://purl.obolibrary.org/obo/GO_0010670 GO:0009685 biolink:BiologicalProcess gibberellin metabolic process The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. go.json gibberellic acid metabolic process|gibberellic acid metabolism|gibberellin metabolism http://purl.obolibrary.org/obo/GO_0009685 GO:0009686 biolink:BiologicalProcess gibberellin biosynthetic process The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. MetaCyc:PWY-5035|MetaCyc:PWY-5036|MetaCyc:PWY-5052|MetaCyc:PWY-5070 go.json gibberellic acid anabolism|gibberellic acid biosynthesis|gibberellic acid biosynthetic process|gibberellic acid formation|gibberellic acid synthesis|gibberellin biosynthesis http://purl.obolibrary.org/obo/GO_0009686 GO:0034620 biolink:BiologicalProcess cellular response to unfolded protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. go.json heat shock protein activity http://purl.obolibrary.org/obo/GO_0034620 GO:0010675 biolink:BiologicalProcess obsolete regulation of cellular carbohydrate metabolic process OBSOLETE. Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. go.json True http://purl.obolibrary.org/obo/GO_0010675 GO:0019009 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019009 GO:0010676 biolink:BiologicalProcess obsolete positive regulation of cellular carbohydrate metabolic process OBSOLETE. Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. go.json True http://purl.obolibrary.org/obo/GO_0010676 GO:0009687 biolink:BiologicalProcess abscisic acid metabolic process The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. go.json abscisic acid metabolism http://purl.obolibrary.org/obo/GO_0009687 GO:0034621 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034621 GO:0009688 biolink:BiologicalProcess abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. MetaCyc:PWY-695 go.json abscisic acid anabolism|abscisic acid biosynthesis|abscisic acid formation|abscisic acid synthesis http://purl.obolibrary.org/obo/GO_0009688 GO:0034622 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034622 GO:0010673 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. go.json activation of meiosis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter, meiotic|stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0010673 GO:0019007 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019007 GO:0019008 biolink:CellularComponent molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. go.json molybdopterin converting factor complex http://purl.obolibrary.org/obo/GO_0019008 goslim_metagenomics GO:0009689 biolink:BiologicalProcess induction of phytoalexin biosynthetic process The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection. go.json induction of phytoalexin anabolism|induction of phytoalexin biosynthesis|induction of phytoalexin formation|induction of phytoalexin synthesis http://purl.obolibrary.org/obo/GO_0009689 GO:0010674 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. go.json activation of meiosis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter, meiotic|positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0010674 GO:0034623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034623 GO:0019005 biolink:CellularComponent SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). Wikipedia:SCF_complex go.json CDL1 complex|CRL1 complex|Cul1-RING ubiquitin ligase complex|SCF complex|SCF complex substrate recognition subunit|Skp1/Cul1/F-box protein complex|cullin-RING ligase 1 http://purl.obolibrary.org/obo/GO_0019005 GO:0019006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019006 GO:0019003 biolink:MolecularActivity GDP binding Binding to GDP, guanosine 5'-diphosphate. go.json http://purl.obolibrary.org/obo/GO_0019003 GO:0019004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019004 GO:0019001 biolink:MolecularActivity guanyl nucleotide binding Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate. Reactome:R-HSA-156909 go.json http://purl.obolibrary.org/obo/GO_0019001 GO:0019002 biolink:MolecularActivity GMP binding Binding to GMP, guanosine monophosphate. go.json http://purl.obolibrary.org/obo/GO_0019002 GO:0019000 biolink:MolecularActivity obsolete endonuclease G activity OBSOLETE. (Was not defined before being made obsolete). go.json endonuclease G activity True http://purl.obolibrary.org/obo/GO_0019000 GO:0034594 biolink:MolecularActivity phosphatidylinositol trisphosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0034594 GO:0034595 biolink:MolecularActivity phosphatidylinositol phosphate 5-phosphatase activity Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. go.json phosphoinositide 5-phosphatase activity|polyphosphoinositol lipid 5-phosphatase activity http://purl.obolibrary.org/obo/GO_0034595 GO:0034596 biolink:MolecularActivity phosphatidylinositol phosphate 4-phosphatase activity Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. Reactome:R-HSA-1675988|Reactome:R-HSA-1676124|Reactome:R-HSA-1676133|Reactome:R-HSA-8849969 go.json PI(4)P-phosphatase activity|PI4P-phosphatase activity|PtdIns4P-phosphatase activity|inositol 4-phosphatase|phosphoinositide 4-phosphatase activity http://purl.obolibrary.org/obo/GO_0034596 GO:0034597 biolink:MolecularActivity phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. EC:3.1.3.78|RHEA:25674|Reactome:R-HSA-6810410 go.json 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity|phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0034597 GO:0034598 biolink:MolecularActivity phosphothreonine lyase activity Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product. go.json http://purl.obolibrary.org/obo/GO_0034598 GO:0034599 biolink:BiologicalProcess cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json adaptive response to oxidative stress http://purl.obolibrary.org/obo/GO_0034599 GO:0034590 biolink:MolecularActivity L-hydroxyproline transmembrane transporter activity Enables the transfer of L-hydroxyproline from one side of a membrane to the other. Reactome:R-HSA-6784213 go.json 4-hydroxyproline transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0034590 GO:0034591 biolink:CellularComponent rhoptry lumen The volume enclosed by the rhoptry membrane. go.json http://purl.obolibrary.org/obo/GO_0034591 GO:0034592 biolink:CellularComponent synaptic vesicle lumen The volume enclosed by the synaptic vesicle membrane. go.json http://purl.obolibrary.org/obo/GO_0034592 goslim_synapse GO:0034593 biolink:MolecularActivity phosphatidylinositol bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate. go.json diphosphoinositide phosphatase activity|phosphatidyl-inositol-bisphosphate phosphatase activity|phosphatidylinositol-bisphosphatase activity|triphosphoinositide phosphatase activity|triphosphoinositide phosphomonoesterase activity http://purl.obolibrary.org/obo/GO_0034593 GO:0034583 biolink:MolecularActivity 21U-RNA binding Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. go.json http://purl.obolibrary.org/obo/GO_0034583 GO:0034584 biolink:MolecularActivity piRNA binding Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. go.json Piwi-associated RNA binding http://purl.obolibrary.org/obo/GO_0034584 GO:0034585 biolink:BiologicalProcess 21U-RNA metabolic process The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. go.json 21U-RNA metabolism http://purl.obolibrary.org/obo/GO_0034585 GO:0034586 biolink:BiologicalProcess 21U-RNA catabolic process The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. go.json 21U-RNA breakdown|21U-RNA catabolism|21U-RNA degradation http://purl.obolibrary.org/obo/GO_0034586 GO:0034587 biolink:BiologicalProcess piRNA processing A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. go.json PIWI-associated RNA biogenesis|PIWI-associated RNA processing|Piwi-associated RNA biosynthetic process|Piwi-associated RNA metabolic process|piRNA biogenesis|piRNA biosynthetic process|piRNA metabolic process|piRNA metabolism http://purl.obolibrary.org/obo/GO_0034587 goslim_drosophila GO:0034588 biolink:BiologicalProcess obsolete piRNA catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. go.json Piwi-associated RNA catabolic process|piRNA breakdown|piRNA catabolism|piRNA degradation True http://purl.obolibrary.org/obo/GO_0034588 GO:0034589 biolink:BiologicalProcess hydroxyproline transport The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 4-hydroxyproline transport|L-hydroxyproline transport http://purl.obolibrary.org/obo/GO_0034589 GO:0034580 biolink:MolecularActivity 4-methyloctanoyl-CoA dehydrogenase activity Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-. EC:1.3.99.-|UM-BBD_reactionID:r0924 go.json http://purl.obolibrary.org/obo/GO_0034580 GO:0034581 biolink:MolecularActivity 4-methyloct-2-enoyl-CoA hydratase activity Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA. UM-BBD_reactionID:r0925 go.json http://purl.obolibrary.org/obo/GO_0034581 GO:0034582 biolink:MolecularActivity 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-. UM-BBD_reactionID:r0926 go.json http://purl.obolibrary.org/obo/GO_0034582 GO:0010767 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. go.json True http://purl.obolibrary.org/obo/GO_0010767 GO:0034734 biolink:CellularComponent transcription factor TFIIIC1 complex A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity. go.json http://purl.obolibrary.org/obo/GO_0034734 GO:0034735 biolink:CellularComponent transcription factor TFIIIC2 complex A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter. go.json http://purl.obolibrary.org/obo/GO_0034735 GO:0010768 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. go.json True http://purl.obolibrary.org/obo/GO_0010768 GO:0034736 biolink:MolecularActivity cholesterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. EC:2.3.1.26|KEGG_REACTION:R01461|MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN|RHEA:17729|Reactome:R-HSA-8876696 go.json ACAT activity|acyl coenzyme A-cholesterol-O-acyltransferase activity|acyl-CoA:cholesterol O-acyltransferase activity|acyl-CoA:cholesterol acyltransferase activity|acylcoenzyme A:cholesterol O-acyltransferase activity|cholesterol acyltransferase activity|cholesterol ester synthetase activity|cholesteryl ester synthetase activity http://purl.obolibrary.org/obo/GO_0034736 GO:0010765 biolink:BiologicalProcess positive regulation of sodium ion transport Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010765 GO:0010766 biolink:BiologicalProcess negative regulation of sodium ion transport Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010766 GO:0034737 biolink:MolecularActivity ergosterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester. go.json http://purl.obolibrary.org/obo/GO_0034737 GO:0034738 biolink:MolecularActivity lanosterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester. go.json http://purl.obolibrary.org/obo/GO_0034738 GO:0034739 biolink:MolecularActivity histone H4K16 deacetylase activity Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. go.json histone H4-K16 deacetylase activity|histone deacetylase activity (H4-K16 specific) http://purl.obolibrary.org/obo/GO_0034739 GO:0010769 biolink:BiologicalProcess obsolete regulation of cell morphogenesis involved in differentiation OBSOLETE. Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. go.json True http://purl.obolibrary.org/obo/GO_0010769 GO:0009780 biolink:BiologicalProcess photosynthetic NADP+ reduction An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions. go.json http://purl.obolibrary.org/obo/GO_0009780 GO:0009770 biolink:BiologicalProcess obsolete primary charge separation in photosystem I OBSOLETE. Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side. go.json True http://purl.obolibrary.org/obo/GO_0009770 GO:0009771 biolink:BiologicalProcess obsolete primary charge separation in photosystem II OBSOLETE. Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side. go.json True http://purl.obolibrary.org/obo/GO_0009771 GO:0010760 biolink:BiologicalProcess negative regulation of macrophage chemotaxis Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0010760 GO:0009772 biolink:BiologicalProcess photosynthetic electron transport in photosystem II A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. go.json http://purl.obolibrary.org/obo/GO_0009772 GO:0009773 biolink:BiologicalProcess photosynthetic electron transport in photosystem I A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP. go.json http://purl.obolibrary.org/obo/GO_0009773 GO:0010763 biolink:BiologicalProcess positive regulation of fibroblast migration Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. go.json positive regulation of fibroblast cell migration http://purl.obolibrary.org/obo/GO_0010763 GO:0034730 biolink:CellularComponent SmD-containing SMN-Sm protein complex An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex. go.json SMN-containing protein complex http://purl.obolibrary.org/obo/GO_0034730 GO:0009774 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009774 GO:0034731 biolink:CellularComponent Lsm-containing SMN-Sm protein complex An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA. go.json SMN-containing protein complex http://purl.obolibrary.org/obo/GO_0034731 GO:0009775 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009775 GO:0010764 biolink:BiologicalProcess negative regulation of fibroblast migration Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. go.json negative regulation of fibroblast cell migration http://purl.obolibrary.org/obo/GO_0010764 GO:0009776 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009776 GO:0034732 biolink:CellularComponent transcription factor TFIIIB-alpha complex A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters. go.json http://purl.obolibrary.org/obo/GO_0034732 GO:0010761 biolink:BiologicalProcess fibroblast migration Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. go.json fibroblast cell migration http://purl.obolibrary.org/obo/GO_0010761 GO:0034733 biolink:CellularComponent transcription factor TFIIIB-beta complex A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters. go.json http://purl.obolibrary.org/obo/GO_0034733 GO:0010762 biolink:BiologicalProcess regulation of fibroblast migration Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. go.json regulation of fibroblast cell migration http://purl.obolibrary.org/obo/GO_0010762 GO:0009777 biolink:BiologicalProcess photosynthetic phosphorylation Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation. go.json photosynthetic ATP synthesis http://purl.obolibrary.org/obo/GO_0009777 GO:0009778 biolink:BiologicalProcess cyclic photosynthetic phosphorylation A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I. go.json http://purl.obolibrary.org/obo/GO_0009778 GO:0009779 biolink:BiologicalProcess noncyclic photosynthetic phosphorylation A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II. go.json http://purl.obolibrary.org/obo/GO_0009779 GO:0010778 biolink:BiologicalProcess meiotic DNA repair synthesis involved in reciprocal meiotic recombination The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010778 GO:0034723 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034723 GO:0010779 biolink:BiologicalProcess meiotic DNA repair synthesis involved in meiotic gene conversion The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. go.json http://purl.obolibrary.org/obo/GO_0010779 GO:0034724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034724 GO:0034725 biolink:BiologicalProcess obsolete DNA replication-dependent nucleosome disassembly OBSOLETE. The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation. go.json DNA replication-dependent chromatin disassembly True http://purl.obolibrary.org/obo/GO_0034725 GO:0010776 biolink:BiologicalProcess meiotic mismatch repair involved in meiotic gene conversion A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. go.json http://purl.obolibrary.org/obo/GO_0010776 GO:0034726 biolink:BiologicalProcess obsolete DNA replication-independent nucleosome disassembly OBSOLETE. The controlled disassembly of chromatin outside the context of DNA replication. go.json DNA replication-independent chromatin disassembly True http://purl.obolibrary.org/obo/GO_0034726 GO:0010777 biolink:BiologicalProcess meiotic mismatch repair involved in reciprocal meiotic recombination A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010777 GO:0034727 biolink:BiologicalProcess piecemeal microautophagy of the nucleus Degradation of a cell nucleus by microautophagy. go.json PMN http://purl.obolibrary.org/obo/GO_0034727 GO:0034728 biolink:BiologicalProcess nucleosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. go.json nucleosome organisation http://purl.obolibrary.org/obo/GO_0034728 GO:0034729 biolink:BiologicalProcess histone H3-K79 methylation The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone. go.json histone H3 K79 methylation|histone H3K79me|histone lysine H3 K79 methylation http://purl.obolibrary.org/obo/GO_0034729 gocheck_do_not_annotate GO:0009790 biolink:BiologicalProcess embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. Wikipedia:Embryogenesis go.json embryogenesis|embryogenesis and morphogenesis|embryonal development http://purl.obolibrary.org/obo/GO_0009790 gocheck_do_not_manually_annotate|goslim_chembl|goslim_plant GO:0009791 biolink:BiologicalProcess post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. go.json http://purl.obolibrary.org/obo/GO_0009791 goslim_plant GO:0009781 biolink:BiologicalProcess obsolete photosynthetic water oxidation OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle. go.json photosynthetic water oxidation True http://purl.obolibrary.org/obo/GO_0009781 GO:0010770 biolink:BiologicalProcess positive regulation of cell morphogenesis Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. go.json http://purl.obolibrary.org/obo/GO_0010770 GO:0010771 biolink:BiologicalProcess negative regulation of cell morphogenesis Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. go.json http://purl.obolibrary.org/obo/GO_0010771 GO:0009782 biolink:CellularComponent photosystem I antenna complex The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). go.json http://purl.obolibrary.org/obo/GO_0009782 GO:0009783 biolink:CellularComponent photosystem II antenna complex The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). go.json http://purl.obolibrary.org/obo/GO_0009783 GO:0009784 biolink:MolecularActivity transmembrane receptor histidine kinase activity Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. go.json http://purl.obolibrary.org/obo/GO_0009784 GO:0009785 biolink:BiologicalProcess blue light signaling pathway The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm. go.json blue light signalling pathway http://purl.obolibrary.org/obo/GO_0009785 GO:0019108 biolink:MolecularActivity aryl-aldehyde dehydrogenase (NAD) activity Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+. EC:1.2.1.29|MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN|RHEA:11804|UM-BBD_reactionID:r0394 go.json aryl-aldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0019108 GO:0010774 biolink:BiologicalProcess meiotic strand invasion involved in reciprocal meiotic recombination The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010774 GO:0034720 biolink:BiologicalProcess histone H3-K4 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone. go.json H3K4 demethylation (me1 me2 and me3) http://purl.obolibrary.org/obo/GO_0034720 gocheck_do_not_annotate GO:0010775 biolink:BiologicalProcess meiotic strand invasion involved in meiotic gene conversion The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. go.json http://purl.obolibrary.org/obo/GO_0010775 GO:0009786 biolink:BiologicalProcess regulation of asymmetric cell division Any process that modulates the frequency, rate or extent of asymmetric cell division. go.json http://purl.obolibrary.org/obo/GO_0009786 GO:0019109 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019109 GO:0034721 biolink:BiologicalProcess histone H3-K4 demethylation, trimethyl-H3-K4-specific The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone. go.json H3K4 demethylation (me3)|histone H3-K4 tridemethylation http://purl.obolibrary.org/obo/GO_0034721 gocheck_do_not_annotate GO:0009787 biolink:BiologicalProcess regulation of abscisic acid-activated signaling pathway Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling. go.json regulation of abscisic acid mediated signaling pathway|regulation of abscisic acid mediated signalling http://purl.obolibrary.org/obo/GO_0009787 GO:0019106 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019106 GO:0010772 biolink:BiologicalProcess meiotic DNA recombinase assembly involved in reciprocal meiotic recombination The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010772 GO:0009788 biolink:BiologicalProcess negative regulation of abscisic acid-activated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling. go.json down regulation of abscisic acid mediated signaling|down-regulation of abscisic acid mediated signaling|downregulation of abscisic acid mediated signaling|inhibition of abscisic acid mediated signaling|negative regulation of abscisic acid mediated signaling pathway|negative regulation of abscisic acid mediated signalling http://purl.obolibrary.org/obo/GO_0009788 GO:0034722 biolink:MolecularActivity gamma-glutamyl-peptidase activity Catalysis of the cleavage of a gamma-linked glutamate bond. go.json gamma-glutamyl hydrolase activity http://purl.obolibrary.org/obo/GO_0034722 GO:0019107 biolink:MolecularActivity myristoyltransferase activity Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. Reactome:R-HSA-141367|Reactome:R-HSA-162914 go.json http://purl.obolibrary.org/obo/GO_0019107 GO:0010773 biolink:BiologicalProcess meiotic DNA recombinase assembly involved in meiotic gene conversion The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. go.json http://purl.obolibrary.org/obo/GO_0010773 GO:0019104 biolink:MolecularActivity DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Reactome:R-HSA-110218|Reactome:R-HSA-110219|Reactome:R-HSA-110231|Reactome:R-HSA-110232|Reactome:R-HSA-110234|Reactome:R-HSA-110246|Reactome:R-HSA-110248|Reactome:R-HSA-110250|Reactome:R-HSA-110251|Reactome:R-HSA-5220959|Reactome:R-HSA-5221061|Reactome:R-HSA-5649658|Reactome:R-HSA-5649664|Reactome:R-HSA-5649673|Reactome:R-HSA-5649681|Reactome:R-HSA-9629149|Reactome:R-HSA-9629216|Reactome:R-HSA-9629470|Reactome:R-HSA-9629483|Reactome:R-HSA-9629492|Reactome:R-HSA-9629497|Reactome:R-HSA-9629499|Reactome:R-HSA-9635996|Reactome:R-HSA-9636008 go.json DNA glycosylase activity|endonuclease VIII activity http://purl.obolibrary.org/obo/GO_0019104 GO:0009789 biolink:BiologicalProcess positive regulation of abscisic acid-activated signaling pathway Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling. go.json activation of abscisic acid mediated signaling|positive regulation of abscisic acid mediated signaling pathway|positive regulation of abscisic acid mediated signalling|stimulation of abscisic acid mediated signaling|up regulation of abscisic acid mediated signaling|up-regulation of abscisic acid mediated signaling|upregulation of abscisic acid mediated signaling http://purl.obolibrary.org/obo/GO_0009789 GO:0019105 biolink:MolecularActivity obsolete N-palmitoyltransferase activity OBSOLETE. Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule. go.json True http://purl.obolibrary.org/obo/GO_0019105 GO:0019102 biolink:BiologicalProcess male somatic sex determination The determination of sex and sexual phenotypes in a male organism's soma. go.json http://purl.obolibrary.org/obo/GO_0019102 GO:0019103 biolink:MolecularActivity pyrimidine nucleotide binding Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate. go.json http://purl.obolibrary.org/obo/GO_0019103 GO:0019100 biolink:BiologicalProcess male germ-line sex determination The determination of sex and sexual phenotype in a male organism's germ line. go.json http://purl.obolibrary.org/obo/GO_0019100 GO:0019101 biolink:BiologicalProcess female somatic sex determination The determination of sex and sexual phenotypes in a female organism's soma. go.json http://purl.obolibrary.org/obo/GO_0019101 GO:0010745 biolink:BiologicalProcess negative regulation of macrophage derived foam cell differentiation Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. go.json http://purl.obolibrary.org/obo/GO_0010745 GO:0034712 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034712 GO:0034713 biolink:MolecularActivity type I transforming growth factor beta receptor binding Binding to a type I transforming growth factor beta receptor. go.json TGF-beta type I binding|babo binding|babo ligand|baboon binding|baboon ligand|baboon receptor ligand|sax binding|sax ligand|saxophone binding|saxophone ligand|thickveins binding|thickveins ligand|tkv binding|tkv ligand|transforming growth factor beta ligand binding to type I receptor|transforming growth factor beta receptor type I binding|type I TGF-beta binding http://purl.obolibrary.org/obo/GO_0034713 GO:0010746 biolink:BiologicalProcess regulation of long-chain fatty acid import across plasma membrane Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. go.json regulation of plasma membrane long-chain fatty acid transport http://purl.obolibrary.org/obo/GO_0010746 GO:0010743 biolink:BiologicalProcess regulation of macrophage derived foam cell differentiation Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. go.json http://purl.obolibrary.org/obo/GO_0010743 GO:0034714 biolink:MolecularActivity type III transforming growth factor beta receptor binding Binding to a type III transforming growth factor beta receptor. go.json TGF-beta type III binding|betaglycan binding|transforming growth factor beta ligand binding to type III receptor|transforming growth factor beta receptor type III binding|type IIII TGF-beta binding http://purl.obolibrary.org/obo/GO_0034714 GO:0010744 biolink:BiologicalProcess positive regulation of macrophage derived foam cell differentiation Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. go.json http://purl.obolibrary.org/obo/GO_0010744 GO:0034715 biolink:CellularComponent pICln-Sm protein complex A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG. go.json 6S pICln complex http://purl.obolibrary.org/obo/GO_0034715 GO:0010749 biolink:BiologicalProcess regulation of nitric oxide mediated signal transduction Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). go.json regulation of nitric oxide-mediated signal transduction http://purl.obolibrary.org/obo/GO_0010749 GO:0034716 biolink:CellularComponent Gemin3-Gemin4-Gemin5 complex A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly. go.json http://purl.obolibrary.org/obo/GO_0034716 GO:0034717 biolink:CellularComponent Gemin6-Gemin7-unrip complex A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly. go.json http://purl.obolibrary.org/obo/GO_0034717 GO:0034718 biolink:CellularComponent SMN-Gemin2 complex A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex. go.json http://purl.obolibrary.org/obo/GO_0034718 GO:0010747 biolink:BiologicalProcess positive regulation of long-chain fatty acid import across plasma membrane Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. go.json positive regulation of plasma membrane long-chain fatty acid transport http://purl.obolibrary.org/obo/GO_0010747 GO:0034719 biolink:CellularComponent SMN-Sm protein complex A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. go.json SMN-containing protein complex http://purl.obolibrary.org/obo/GO_0034719 GO:0010748 biolink:BiologicalProcess negative regulation of long-chain fatty acid import across plasma membrane Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. go.json negative regulation of plasma membrane long-chain fatty acid transport http://purl.obolibrary.org/obo/GO_0010748 GO:0009750 biolink:BiologicalProcess response to fructose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. go.json response to fructose stimulus http://purl.obolibrary.org/obo/GO_0009750 GO:0009751 biolink:BiologicalProcess response to salicylic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. go.json response to salicylate|response to salicylic acid stimulus http://purl.obolibrary.org/obo/GO_0009751 GO:0009752 biolink:BiologicalProcess detection of salicylic acid stimulus The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal. go.json perception of salicylic acid stimulus http://purl.obolibrary.org/obo/GO_0009752 GO:0010741 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010741 GO:0009753 biolink:BiologicalProcess response to jasmonic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. go.json response to jasmonic acid stimulus http://purl.obolibrary.org/obo/GO_0009753 GO:0010742 biolink:BiologicalProcess macrophage derived foam cell differentiation The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. go.json http://purl.obolibrary.org/obo/GO_0010742 GO:0009754 biolink:BiologicalProcess detection of jasmonic acid stimulus The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule. go.json perception of jasmonic acid stimulus http://purl.obolibrary.org/obo/GO_0009754 GO:0034710 biolink:MolecularActivity inhibin complex binding Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit. go.json http://purl.obolibrary.org/obo/GO_0034710 GO:0034711 biolink:MolecularActivity inhibin binding Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers. go.json inhibin alpha binding|inhibin beta-A binding|inhibin beta-B binding|inhibin monomer binding http://purl.obolibrary.org/obo/GO_0034711 GO:0009755 biolink:BiologicalProcess hormone-mediated signaling pathway The series of molecular signals mediated by the detection of a hormone. go.json hormone mediated signalling http://purl.obolibrary.org/obo/GO_0009755 GO:0010740 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010740 GO:0009756 biolink:BiologicalProcess carbohydrate mediated signaling The series of molecular signals mediated by the detection of carbohydrate. go.json carbohydrate mediated signalling http://purl.obolibrary.org/obo/GO_0009756 GO:0009757 biolink:BiologicalProcess hexose mediated signaling The series of molecular signals mediated by the detection of hexose. go.json hexose mediated signalling http://purl.obolibrary.org/obo/GO_0009757 GO:0009758 biolink:BiologicalProcess carbohydrate utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism. go.json sugar utilization http://purl.obolibrary.org/obo/GO_0009758 GO:0009759 biolink:BiologicalProcess indole glucosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. go.json indole glucosinolate anabolism|indole glucosinolate biosynthesis|indole glucosinolate formation|indole glucosinolate synthesis http://purl.obolibrary.org/obo/GO_0009759 GO:0034709 biolink:CellularComponent methylosome A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. go.json 20S methylosome|20S methyltransferase complex http://purl.obolibrary.org/obo/GO_0034709 GO:0010756 biolink:BiologicalProcess positive regulation of plasminogen activation Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. go.json http://purl.obolibrary.org/obo/GO_0010756 GO:0034701 biolink:MolecularActivity tripeptidase activity Catalysis of the hydrolysis of a tripeptide. MetaCyc:3.4.11.4-RXN go.json http://purl.obolibrary.org/obo/GO_0034701 GO:0034702 biolink:CellularComponent monoatomic ion channel complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient. go.json http://purl.obolibrary.org/obo/GO_0034702 GO:0010757 biolink:BiologicalProcess negative regulation of plasminogen activation Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. go.json inhibition of plasminogen activation http://purl.obolibrary.org/obo/GO_0010757 GO:0010754 biolink:BiologicalProcess negative regulation of cGMP-mediated signaling Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. go.json negative regulation of cGMP-mediated signalling http://purl.obolibrary.org/obo/GO_0010754 GO:0034703 biolink:CellularComponent cation channel complex An ion channel complex through which cations pass. go.json http://purl.obolibrary.org/obo/GO_0034703 GO:0010755 biolink:BiologicalProcess regulation of plasminogen activation Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. go.json http://purl.obolibrary.org/obo/GO_0010755 GO:0034704 biolink:CellularComponent calcium channel complex An ion channel complex through which calcium ions pass. go.json http://purl.obolibrary.org/obo/GO_0034704 GO:0034705 biolink:CellularComponent potassium channel complex An ion channel complex through which potassium ions pass. go.json http://purl.obolibrary.org/obo/GO_0034705 GO:0034706 biolink:CellularComponent sodium channel complex An ion channel complex through which sodium ions pass. go.json http://purl.obolibrary.org/obo/GO_0034706 GO:0034707 biolink:CellularComponent chloride channel complex An ion channel complex through which chloride ions pass. go.json http://purl.obolibrary.org/obo/GO_0034707 GO:0010758 biolink:BiologicalProcess regulation of macrophage chemotaxis Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0010758 GO:0034708 biolink:CellularComponent methyltransferase complex A protein complex that possesses methyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0034708 GO:0010759 biolink:BiologicalProcess positive regulation of macrophage chemotaxis Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0010759 GO:0009760 biolink:BiologicalProcess C4 photosynthesis The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch. Wikipedia:C4_carbon_fixation go.json http://purl.obolibrary.org/obo/GO_0009760 GO:0009761 biolink:BiologicalProcess CAM photosynthesis The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis. Wikipedia:Crassulacean_acid_metabolism go.json http://purl.obolibrary.org/obo/GO_0009761 GO:0009762 biolink:BiologicalProcess NADP-malic enzyme C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme. MetaCyc:PWY-241 go.json http://purl.obolibrary.org/obo/GO_0009762 GO:0010752 biolink:BiologicalProcess regulation of cGMP-mediated signaling Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. go.json regulation of cGMP-mediated signalling http://purl.obolibrary.org/obo/GO_0010752 GO:0009763 biolink:BiologicalProcess NAD-malic enzyme C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme. go.json http://purl.obolibrary.org/obo/GO_0009763 GO:0010753 biolink:BiologicalProcess positive regulation of cGMP-mediated signaling Any process that increases the rate, frequency or extent of cGMP-mediated signaling. go.json positive regulation of cGMP-mediated signalling http://purl.obolibrary.org/obo/GO_0010753 GO:0009764 biolink:BiologicalProcess PEP carboxykinase C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK). go.json http://purl.obolibrary.org/obo/GO_0009764 GO:0010750 biolink:BiologicalProcess positive regulation of nitric oxide mediated signal transduction Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). go.json positive regulation of nitric oxide-mediated signal transduction http://purl.obolibrary.org/obo/GO_0010750 GO:0009765 biolink:BiologicalProcess photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. go.json energy dissipation http://purl.obolibrary.org/obo/GO_0009765 GO:0010751 biolink:BiologicalProcess negative regulation of nitric oxide mediated signal transduction Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). go.json negative regulation of nitric oxide-mediated signal transduction http://purl.obolibrary.org/obo/GO_0010751 GO:0034700 biolink:MolecularActivity allulose 6-phosphate 3-epimerase activity Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate. MetaCyc:RXN0-304|RHEA:28426 go.json http://purl.obolibrary.org/obo/GO_0034700 GO:0009766 biolink:BiologicalProcess obsolete primary charge separation OBSOLETE. In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes. go.json True http://purl.obolibrary.org/obo/GO_0009766 GO:0009767 biolink:BiologicalProcess photosynthetic electron transport chain A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. go.json electron carrier, chlorophyll electron transport system|photosynthetic electron transport in cytochrome b6/f|photosynthetic electron transport in plastocyanin|photosynthetic electron transport in plastoquinone http://purl.obolibrary.org/obo/GO_0009767 GO:0009768 biolink:BiologicalProcess photosynthesis, light harvesting in photosystem I After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. go.json http://purl.obolibrary.org/obo/GO_0009768 GO:0009769 biolink:BiologicalProcess photosynthesis, light harvesting in photosystem II After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. go.json http://purl.obolibrary.org/obo/GO_0009769 GO:0010729 biolink:BiologicalProcess positive regulation of hydrogen peroxide biosynthetic process Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. go.json positive regulation of hydrogen peroxide biosynthesis http://purl.obolibrary.org/obo/GO_0010729 GO:0010723 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter in response to iron Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. go.json http://purl.obolibrary.org/obo/GO_0010723 GO:0044104 biolink:MolecularActivity 2,5-dioxovalerate dehydrogenase (NAD+) activity Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+. go.json 2,5-dioxopentanoate dehydrogenase (NAD+) activity|2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0044104 GO:0010724 biolink:BiologicalProcess regulation of definitive erythrocyte differentiation Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis. go.json regulation of definitive RBC differentiation|regulation of definitive erythropoiesis|regulation of definitive red blood cell differentiation http://purl.obolibrary.org/obo/GO_0010724 GO:0044105 biolink:MolecularActivity L-xylulose reductase (NAD+) activity Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+. go.json http://purl.obolibrary.org/obo/GO_0044105 GO:0010721 biolink:BiologicalProcess negative regulation of cell development Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0010721 GO:0044102 biolink:MolecularActivity purine deoxyribosyltransferase activity Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor. go.json PTD|purine 2'-deoxyribosyltransferase activity http://purl.obolibrary.org/obo/GO_0044102 GO:0010722 biolink:BiologicalProcess regulation of ferrochelatase activity Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. go.json http://purl.obolibrary.org/obo/GO_0010722 gocheck_do_not_annotate GO:0044103 biolink:MolecularActivity L-arabinose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+. EC:1.1.1.376 go.json http://purl.obolibrary.org/obo/GO_0044103 GO:0044100 biolink:CellularComponent sporoplasm The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms. go.json http://purl.obolibrary.org/obo/GO_0044100 GO:0010727 biolink:BiologicalProcess negative regulation of hydrogen peroxide metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. go.json negative regulation of hydrogen peroxide metabolism http://purl.obolibrary.org/obo/GO_0010727 GO:0010728 biolink:BiologicalProcess regulation of hydrogen peroxide biosynthetic process Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. go.json regulation of hydrogen peroxide biosynthesis http://purl.obolibrary.org/obo/GO_0010728 GO:0044101 biolink:MolecularActivity (3R)-citramalyl-CoA lyase activity Catalysis of the reaction: (3R)-citramalyl-CoA = pyruvate + acetyl-CoA. EC:4.1.3.46|MetaCyc:RXN-13231|RHEA:38275 go.json Ccl|R-citramalyl-CoA lyase activity http://purl.obolibrary.org/obo/GO_0044101 GO:0010725 biolink:BiologicalProcess regulation of primitive erythrocyte differentiation Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis. go.json regulation of primitive RBC differentiation|regulation of primitive erythropoeisis|regulation of primitive red blood cell differentiation http://purl.obolibrary.org/obo/GO_0010725 GO:0010726 biolink:BiologicalProcess positive regulation of hydrogen peroxide metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. go.json positive regulation of hydrogen peroxide metabolism http://purl.obolibrary.org/obo/GO_0010726 GO:0044108 biolink:BiologicalProcess obsolete cellular alcohol biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell. go.json True http://purl.obolibrary.org/obo/GO_0044108 GO:0009730 biolink:BiologicalProcess detection of carbohydrate stimulus The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal. go.json perception of carbohydrate stimulus http://purl.obolibrary.org/obo/GO_0009730 GO:0010720 biolink:BiologicalProcess positive regulation of cell development Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. go.json http://purl.obolibrary.org/obo/GO_0010720 GO:0044109 biolink:BiologicalProcess obsolete cellular alcohol catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell. go.json True http://purl.obolibrary.org/obo/GO_0044109 GO:0009731 biolink:BiologicalProcess detection of sucrose stimulus The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal. go.json perception of sucrose stimulus http://purl.obolibrary.org/obo/GO_0009731 GO:0044106 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044106 GO:0009732 biolink:BiologicalProcess detection of hexose stimulus The series of events in which a stimulus from a hexose is received and converted into a molecular signal. go.json perception of hexose stimulus http://purl.obolibrary.org/obo/GO_0009732 GO:0009733 biolink:BiologicalProcess response to auxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. go.json response to auxin stimulus http://purl.obolibrary.org/obo/GO_0009733 GO:0044107 biolink:BiologicalProcess obsolete cellular alcohol metabolic process OBSOLETE. The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells. go.json True http://purl.obolibrary.org/obo/GO_0044107 GO:0009734 biolink:BiologicalProcess auxin-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. go.json auxin mediated signaling pathway|auxin mediated signalling|auxin signal transduction|auxin signaling|auxin-regulated transcription http://purl.obolibrary.org/obo/GO_0009734 GO:0009735 biolink:BiologicalProcess response to cytokinin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. go.json response to cytokinin stimulus http://purl.obolibrary.org/obo/GO_0009735 GO:0009736 biolink:BiologicalProcess cytokinin-activated signaling pathway The series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json cytokinin mediated signaling pathway|cytokinin mediated signalling|cytokinin signaling http://purl.obolibrary.org/obo/GO_0009736 GO:0009737 biolink:BiologicalProcess response to abscisic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. go.json response to abscisic acid stimulus http://purl.obolibrary.org/obo/GO_0009737 GO:0009738 biolink:BiologicalProcess abscisic acid-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription. go.json ABA signal transduction|ABA signaling|abscisic acid mediated signalling|abscisic acid signal transduction|abscisic acid-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0009738 GO:0009739 biolink:BiologicalProcess response to gibberellin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. go.json response to gibberellic acid stimulus|response to gibberellin stimulus http://purl.obolibrary.org/obo/GO_0009739 GO:0010734 biolink:BiologicalProcess negative regulation of protein glutathionylation Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. go.json negative regulation of protein amino acid glutathionylation http://purl.obolibrary.org/obo/GO_0010734 GO:0044115 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044115 GO:0010735 biolink:BiologicalProcess obsolete positive regulation of transcription via serum response element binding OBSOLETE. Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. go.json True http://purl.obolibrary.org/obo/GO_0010735 GO:0044116 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044116 GO:0044113 biolink:BiologicalProcess obsolete development in other organism involved in symbiotic interaction OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism. go.json development in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0044113 GO:0010732 biolink:BiologicalProcess regulation of protein glutathionylation Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. go.json regulation of protein amino acid glutathionylation http://purl.obolibrary.org/obo/GO_0010732 GO:0044114 biolink:BiologicalProcess development of symbiont in host The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json development of symbiont in host intercellular space|development of symbiont in host vascular tissue http://purl.obolibrary.org/obo/GO_0044114 GO:0010733 biolink:BiologicalProcess positive regulation of protein glutathionylation Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. go.json positive regulation of protein amino acid glutathionylation http://purl.obolibrary.org/obo/GO_0010733 GO:0010738 biolink:BiologicalProcess regulation of protein kinase A signaling Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. go.json regulation of PKA signaling cascade|regulation of protein kinase A signaling cascade|regulation of protein kinase A signalling cascade http://purl.obolibrary.org/obo/GO_0010738 GO:0044111 biolink:BiologicalProcess formation of structure involved in a symbiotic process The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. go.json development during symbiotic interaction|development involved in symbiotic interaction|development of symbiont during interaction with host|development of symbiont involved in interaction with host|development on or near surface of other organism during symbiotic interaction|development on or near surface of other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0044111 GO:0044112 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044112 GO:0010739 biolink:BiologicalProcess positive regulation of protein kinase A signaling Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. go.json positive regulation of PKA signaling cascade|positive regulation of protein kinase A signaling cascade|positive regulation of protein kinase A signalling cascade http://purl.obolibrary.org/obo/GO_0010739 GO:0010736 biolink:MolecularActivity serum response element binding Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. go.json http://purl.obolibrary.org/obo/GO_0010736 GO:0044110 biolink:BiologicalProcess obsolete growth involved in symbiotic interaction OBSOLETE. The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction. go.json growth during symbiotic interaction|growth on or near surface of other organism during symbiotic interaction|growth on or near surface of other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0044110 GO:0010737 biolink:BiologicalProcess protein kinase A signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. go.json PKA signaling cascade|protein kinase A signal transduction|protein kinase A signaling cascade|protein kinase A signalling cascade http://purl.obolibrary.org/obo/GO_0010737 GO:0009740 biolink:BiologicalProcess gibberellic acid mediated signaling pathway The series of molecular signals mediated by the detection of gibberellic acid. go.json GA-signaling|gibberellic acid mediated signalling|gibberellic acid signaling http://purl.obolibrary.org/obo/GO_0009740 GO:0010730 biolink:BiologicalProcess negative regulation of hydrogen peroxide biosynthetic process Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. go.json negative regulation of hydrogen peroxide biosynthesis http://purl.obolibrary.org/obo/GO_0010730 GO:0009741 biolink:BiologicalProcess response to brassinosteroid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. go.json response to brassinosteroid stimulus http://purl.obolibrary.org/obo/GO_0009741 GO:0044119 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044119 GO:0010731 biolink:BiologicalProcess protein glutathionylation The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. go.json protein amino acid glutathionylation http://purl.obolibrary.org/obo/GO_0010731 gocheck_do_not_annotate GO:0009742 biolink:BiologicalProcess brassinosteroid mediated signaling pathway The series of molecular signals mediated by the detection of brassinosteroid. go.json brassinosteroid mediated signalling http://purl.obolibrary.org/obo/GO_0009742 GO:0009743 biolink:BiologicalProcess response to carbohydrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. go.json response to carbohydrate stimulus http://purl.obolibrary.org/obo/GO_0009743 GO:0044117 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044117 GO:0009744 biolink:BiologicalProcess response to sucrose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. go.json response to sucrose stimulus http://purl.obolibrary.org/obo/GO_0009744 GO:0044118 biolink:BiologicalProcess obsolete development of symbiont in host cell OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044118 GO:0009745 biolink:BiologicalProcess sucrose mediated signaling The series of molecular signals mediated by the detection of sucrose. go.json sucrose mediated signalling http://purl.obolibrary.org/obo/GO_0009745 GO:0009746 biolink:BiologicalProcess response to hexose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. go.json response to hexose stimulus http://purl.obolibrary.org/obo/GO_0009746 GO:0009747 biolink:BiologicalProcess hexokinase-dependent signaling The series of molecular signals mediated by hexose and dependent on the detection of hexokinase. go.json hexokinase-dependent signalling http://purl.obolibrary.org/obo/GO_0009747 GO:0009748 biolink:BiologicalProcess hexokinase-independent signaling The series of molecular signals mediated by hexose and independent of hexokinase. go.json hexokinase-independent signalling http://purl.obolibrary.org/obo/GO_0009748 GO:0009749 biolink:BiologicalProcess response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. go.json response to glucose stimulus http://purl.obolibrary.org/obo/GO_0009749 GO:0010709 biolink:BiologicalProcess heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences. go.json http://purl.obolibrary.org/obo/GO_0010709 GO:0010707 biolink:BiologicalProcess globoside biosynthetic process via lactosylceramide The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. go.json biosynthesis of lactosylceramide precursor to globoside|globoside biosynthesis via lactosylceramide biosynthesis|lactosylceramide biosynthesis leading to globoside|lactosylceramide biosynthetic process leading to globoside http://purl.obolibrary.org/obo/GO_0010707 GO:0010708 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010708 GO:0010701 biolink:BiologicalProcess positive regulation of norepinephrine secretion Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. go.json http://purl.obolibrary.org/obo/GO_0010701 GO:0044126 biolink:BiologicalProcess obsolete regulation of growth of symbiont in host OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044126 GO:0044127 biolink:BiologicalProcess regulation of development of symbiont in host Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044127 GO:0010702 biolink:BiologicalProcess obsolete regulation of histolysis OBSOLETE. Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death. go.json True http://purl.obolibrary.org/obo/GO_0010702 GO:0044124 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044124 GO:0044125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044125 GO:0010700 biolink:BiologicalProcess negative regulation of norepinephrine secretion Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. go.json http://purl.obolibrary.org/obo/GO_0010700 GO:0044122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044122 GO:0010705 biolink:BiologicalProcess meiotic DNA double-strand break processing involved in reciprocal meiotic recombination The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010705 GO:0044123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044123 GO:0010706 biolink:BiologicalProcess ganglioside biosynthetic process via lactosylceramide The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. go.json biosynthesis of lactosylceramide precursor to ganglioside|ganglioside biosynthesis via lactosylceramide biosynthesis|lactosylceramide biosynthesis leading to ganglioside|lactosylceramide biosynthetic process leading to ganglioside http://purl.obolibrary.org/obo/GO_0010706 GO:0044120 biolink:BiologicalProcess obsolete development of symbiont in host vacuole OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring in a host vacuole. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json development of symbiont in host organelle True http://purl.obolibrary.org/obo/GO_0044120 GO:0010703 biolink:BiologicalProcess obsolete negative regulation of histolysis OBSOLETE. Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death. go.json down regulation of histolysis|down-regulation of histolysis|downregulation of histolysis|inhibition of histolysis True http://purl.obolibrary.org/obo/GO_0010703 GO:0044121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044121 GO:0010704 biolink:BiologicalProcess meiotic DNA double-strand break processing involved in meiotic gene conversion The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another. go.json http://purl.obolibrary.org/obo/GO_0010704 GO:0009710 biolink:BiologicalProcess tropane alkaloid biosynthetic process The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. go.json tropane alkaloid anabolism|tropane alkaloid biosynthesis|tropane alkaloid formation|tropane alkaloid synthesis http://purl.obolibrary.org/obo/GO_0009710 GO:0044128 biolink:BiologicalProcess obsolete positive regulation of growth of symbiont in host OBSOLETE. Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044128 GO:0009711 biolink:BiologicalProcess purine alkaloid biosynthetic process The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure. go.json purine alkaloid anabolism|purine alkaloid biosynthesis|purine alkaloid formation|purine alkaloid synthesis http://purl.obolibrary.org/obo/GO_0009711 GO:0044129 biolink:BiologicalProcess positive regulation of development of symbiont in host Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044129 GO:0009712 biolink:BiologicalProcess catechol-containing compound metabolic process The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. go.json catechol metabolic process|catechol metabolism http://purl.obolibrary.org/obo/GO_0009712 GO:0009713 biolink:BiologicalProcess catechol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. go.json catechol anabolism|catechol biosynthesis|catechol biosynthetic process|catechol formation|catechol synthesis http://purl.obolibrary.org/obo/GO_0009713 GO:0009714 biolink:BiologicalProcess chalcone metabolic process The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives. go.json chalcone metabolism http://purl.obolibrary.org/obo/GO_0009714 GO:0009715 biolink:BiologicalProcess chalcone biosynthetic process The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives. go.json chalcone anabolism|chalcone biosynthesis|chalcone formation|chalcone synthesis http://purl.obolibrary.org/obo/GO_0009715 GO:0009716 biolink:BiologicalProcess flavonoid phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. go.json flavonoid phytoalexin anabolism|flavonoid phytoalexin biosynthesis|flavonoid phytoalexin formation|flavonoid phytoalexin synthesis http://purl.obolibrary.org/obo/GO_0009716 GO:0009717 biolink:BiologicalProcess isoflavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. go.json isoflavonoid anabolism|isoflavonoid biosynthesis|isoflavonoid formation|isoflavonoid synthesis http://purl.obolibrary.org/obo/GO_0009717 GO:0009718 biolink:BiologicalProcess anthocyanin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. go.json anthocyanin anabolism|anthocyanin biosynthesis|anthocyanin biosynthetic process|anthocyanin formation|anthocyanin synthesis http://purl.obolibrary.org/obo/GO_0009718 GO:0009719 biolink:BiologicalProcess response to endogenous stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. go.json http://purl.obolibrary.org/obo/GO_0009719 gocheck_do_not_manually_annotate|goslim_plant GO:0044130 biolink:BiologicalProcess obsolete negative regulation of growth of symbiont in host OBSOLETE. Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044130 GO:0010718 biolink:BiologicalProcess positive regulation of epithelial to mesenchymal transition Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0010718 GO:0010719 biolink:BiologicalProcess negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0010719 GO:0044137 biolink:BiologicalProcess obsolete growth of symbiont on or near host rhizosphere OBSOLETE. The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044137 GO:0010712 biolink:BiologicalProcess regulation of collagen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. go.json regulation of collagen metabolism http://purl.obolibrary.org/obo/GO_0010712 GO:0044138 biolink:BiologicalProcess obsolete modulation of development of symbiont on or near host OBSOLETE. Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism. go.json True http://purl.obolibrary.org/obo/GO_0044138 GO:0010713 biolink:BiologicalProcess negative regulation of collagen metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. go.json http://purl.obolibrary.org/obo/GO_0010713 GO:0044135 biolink:BiologicalProcess obsolete growth of symbiont on or near host phyllosphere OBSOLETE. The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044135 GO:0010710 biolink:BiologicalProcess regulation of collagen catabolic process Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. go.json regulation of collagen breakdown|regulation of collagen catabolism|regulation of collagen degradation http://purl.obolibrary.org/obo/GO_0010710 GO:0010711 biolink:BiologicalProcess negative regulation of collagen catabolic process Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. go.json down regulation of collagen catabolic process|down-regulation of collagen catabolic process|downregulation of collagen catabolic process|inhibition of collagen catabolic process|negative regulation of collagen breakdown|negative regulation of collagen catabolism|negative regulation of collagen degradation http://purl.obolibrary.org/obo/GO_0010711 GO:0044136 biolink:BiologicalProcess obsolete development of symbiont on or near host rhizosphere OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044136 GO:0044133 biolink:BiologicalProcess obsolete growth of symbiont on or near host OBSOLETE. The increase in size or mass of a symbiont within the cells or tissues of its host organism. go.json True http://purl.obolibrary.org/obo/GO_0044133 GO:0010716 biolink:BiologicalProcess negative regulation of extracellular matrix disassembly Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. go.json down regulation of extracellular matrix disassembly|down-regulation of extracellular matrix disassembly|downregulation of extracellular matrix disassembly|inhibition of extracellular matrix disassembly|negative regulation of extracellular matrix breakdown|negative regulation of extracellular matrix degradation http://purl.obolibrary.org/obo/GO_0010716 GO:0044134 biolink:BiologicalProcess obsolete development of symbiont on or near host phyllosphere OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044134 GO:0010717 biolink:BiologicalProcess regulation of epithelial to mesenchymal transition Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0010717 GO:0044131 biolink:BiologicalProcess negative regulation of development of symbiont in host Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044131 GO:0010714 biolink:BiologicalProcess positive regulation of collagen metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. go.json positive regulation of collagen metabolism http://purl.obolibrary.org/obo/GO_0010714 GO:0044132 biolink:BiologicalProcess obsolete development of symbiont on or near host OBSOLETE. The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism. go.json True http://purl.obolibrary.org/obo/GO_0044132 GO:0010715 biolink:BiologicalProcess regulation of extracellular matrix disassembly Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. go.json regulation of extracellular matrix breakdown|regulation of extracellular matrix degradation http://purl.obolibrary.org/obo/GO_0010715 GO:0009720 biolink:BiologicalProcess detection of hormone stimulus The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal. go.json perception of hormone stimulus http://purl.obolibrary.org/obo/GO_0009720 GO:0009721 biolink:BiologicalProcess detection of auxin stimulus The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal. go.json perception of auxin stimulus http://purl.obolibrary.org/obo/GO_0009721 GO:0044139 biolink:BiologicalProcess obsolete modulation of growth of symbiont on or near host OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism. go.json True http://purl.obolibrary.org/obo/GO_0044139 GO:0009722 biolink:BiologicalProcess detection of cytokinin stimulus The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal. go.json perception of cytokinin stimulus http://purl.obolibrary.org/obo/GO_0009722 GO:0009723 biolink:BiologicalProcess response to ethylene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. go.json response to ethene stimulus|response to ethylene stimulus http://purl.obolibrary.org/obo/GO_0009723 GO:0009724 biolink:BiologicalProcess detection of abscisic acid stimulus The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal. go.json perception of abscisic acid stimulus http://purl.obolibrary.org/obo/GO_0009724 GO:0009725 biolink:BiologicalProcess response to hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. go.json growth regulator|response to hormone stimulus http://purl.obolibrary.org/obo/GO_0009725 GO:0009726 biolink:BiologicalProcess detection of endogenous stimulus The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal. go.json perception of endogenous stimulus http://purl.obolibrary.org/obo/GO_0009726 GO:0009727 biolink:BiologicalProcess detection of ethylene stimulus The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal. go.json detection of ethene stimulus|perception of ethene stimulus|perception of ethylene stimulus http://purl.obolibrary.org/obo/GO_0009727 GO:0009728 biolink:BiologicalProcess detection of gibberellic acid stimulus The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal. go.json perception of gibberellic acid stimulus http://purl.obolibrary.org/obo/GO_0009728 GO:0009729 biolink:BiologicalProcess detection of brassinosteroid stimulus The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal. go.json perception of brassinosteroid stimulus http://purl.obolibrary.org/obo/GO_0009729 GO:0019184 biolink:BiologicalProcess nonribosomal peptide biosynthetic process The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. go.json non-ribosomal peptide biosynthesis|non-ribosomal peptide biosynthetic process|non-ribosomal peptide formation|non-ribosomal peptide synthesis|nonribosomal peptide anabolism|nonribosomal peptide biosynthesis|nonribosomal peptide formation|nonribosomal peptide synthesis|nonribosomal peptide synthetase http://purl.obolibrary.org/obo/GO_0019184 GO:0019185 biolink:CellularComponent snRNA-activating protein complex A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters. go.json SNAPc http://purl.obolibrary.org/obo/GO_0019185 GO:0019182 biolink:MolecularActivity histamine-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0019182 GO:0019183 biolink:CellularComponent histamine-gated chloride channel complex A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0019183 GO:0019180 biolink:MolecularActivity dTDP-4-amino-4,6-dideoxygalactose transaminase activity Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose. EC:2.6.1.59|KEGG_REACTION:R04438|MetaCyc:RFFTRANS-RXN|RHEA:10368 go.json dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity|dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity|dTDP-fucosamine aminotransferase activity|thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity|thymidine diphosphoaminodideoxygalactose aminotransferase activity http://purl.obolibrary.org/obo/GO_0019180 GO:0019181 biolink:MolecularActivity halohydrin hydrogen-halide-lyase activity Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide. go.json http://purl.obolibrary.org/obo/GO_0019181 GO:0019179 biolink:MolecularActivity dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. EC:2.6.1.33|MetaCyc:2.6.1.33-RXN|RHEA:19085 go.json TDP-4-keto-6-deoxy-D-glucose transaminase activity|TDP-4-oxo-6-deoxy-D-glucose transaminase activity|dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity|dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity|thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity|thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity|thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity|thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity http://purl.obolibrary.org/obo/GO_0019179 GO:0019177 biolink:MolecularActivity dihydroneopterin triphosphate pyrophosphohydrolase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. EC:3.6.1.67|MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN|RHEA:25302 go.json http://purl.obolibrary.org/obo/GO_0019177 GO:0019178 biolink:MolecularActivity NADP phosphatase activity Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate. EC:3.1.3.108|MetaCyc:RXN-5822|RHEA:28050 go.json http://purl.obolibrary.org/obo/GO_0019178 GO:0019175 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019175 GO:0019176 biolink:MolecularActivity dihydroneopterin monophosphate phosphatase activity Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate. MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN|RHEA:25306 go.json dihydroneopterin monophosphate dephosphorylase activity http://purl.obolibrary.org/obo/GO_0019176 GO:0019195 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019195 GO:0019196 biolink:MolecularActivity galactosamine transmembrane transporter activity Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative. go.json galactosamine porter activity http://purl.obolibrary.org/obo/GO_0019196 GO:0019193 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019193 GO:0019194 biolink:MolecularActivity sorbose transmembrane transporter activity Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. go.json sorbose porter activity http://purl.obolibrary.org/obo/GO_0019194 GO:0019191 biolink:MolecularActivity cellobiose transmembrane transporter activity Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. go.json cellobiose permease activity http://purl.obolibrary.org/obo/GO_0019191 GO:0019192 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019192 GO:0019190 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019190 GO:0019188 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019188 GO:0019189 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019189 GO:0019186 biolink:MolecularActivity acyl-CoA N-acyltransferase activity Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0019186 GO:0019187 biolink:MolecularActivity beta-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage. go.json http://purl.obolibrary.org/obo/GO_0019187 GO:0019162 biolink:MolecularActivity pyridoxamine-oxaloacetate transaminase activity Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal. EC:2.6.1.31|KEGG_REACTION:R01713|MetaCyc:PYROXALTRANSAM-RXN|RHEA:10844 go.json pyridoxamine--oxaloacetate aminotransferase activity|pyridoxamine-oxaloacetate aminotransferase activity|pyridoxamine:oxaloacetate aminotransferase activity http://purl.obolibrary.org/obo/GO_0019162 GO:0019163 biolink:MolecularActivity pyridoxamine-phosphate transaminase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate. EC:2.6.1.54|MetaCyc:PYRDAMPTRANS-RXN|RHEA:15877 go.json pyridoxamine 5'-phosphate transaminase activity|pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity|pyridoxamine phosphate aminotransferase activity|pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)|pyridoxamine-phosphate aminotransferase activity http://purl.obolibrary.org/obo/GO_0019163 GO:0019160 biolink:MolecularActivity NMN nucleosidase activity Catalysis of the reaction: H2O + nicotinamide mononucleotide = D-ribose 5-phosphate + H+ + nicotinamide. EC:3.2.2.14|KEGG_REACTION:R01270|MetaCyc:NMNNUCLEOSID-RXN|RHEA:23140 go.json NMN glycohydrolase activity|NMNGhase activity|NMNase activity|nicotinamide mononucleotidase activity|nicotinamide mononucleotide nucleosidase activity|nicotinamide-nucleotide phosphoribohydrolase activity http://purl.obolibrary.org/obo/GO_0019160 GO:0019161 biolink:MolecularActivity diamine transaminase activity Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate. EC:2.6.1.29|MetaCyc:DIAMTRANSAM-RXN|RHEA:18217 go.json amine transaminase activity|amine-ketoacid transaminase activity|diamine aminotransferase activity|diamine-ketoglutaric transaminase activity|diamine:2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0019161 GO:0034792 biolink:MolecularActivity hypophosphite dioxygenase activity Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2. UM-BBD_reactionID:r1058 go.json http://purl.obolibrary.org/obo/GO_0034792 GO:0034793 biolink:MolecularActivity cyclopropanecarboxylate-CoA ligase activity Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-. UM-BBD_reactionID:r1056 go.json http://purl.obolibrary.org/obo/GO_0034793 GO:0034794 biolink:MolecularActivity cyclopropanecarboxyl-CoA decyclase activity Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA. EC:5.5.1.-|UM-BBD_reactionID:r1057 go.json http://purl.obolibrary.org/obo/GO_0034794 GO:0034795 biolink:MolecularActivity cyclohexane monooxygenase activity Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O. EC:1.14.15.-|KEGG_REACTION:R06945|MetaCyc:RXN-8697|UM-BBD_reactionID:r1059 go.json butane monooxygenase activity|cyclohexane hydroxylase activity http://purl.obolibrary.org/obo/GO_0034795 GO:0034796 biolink:MolecularActivity adipate-CoA ligase activity Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-. UM-BBD_reactionID:r1060 go.json http://purl.obolibrary.org/obo/GO_0034796 GO:0034797 biolink:MolecularActivity fosfomycin 2-glutathione ligase activity Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid. UM-BBD_reactionID:r1073 go.json http://purl.obolibrary.org/obo/GO_0034797 GO:0034798 biolink:MolecularActivity fosfomycin 2-L-cysteine ligase activity Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid. UM-BBD_reactionID:r1074 go.json http://purl.obolibrary.org/obo/GO_0034798 GO:0034799 biolink:MolecularActivity dihydride TNP tautomerase activity Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form). UM-BBD_reactionID:r1070 go.json http://purl.obolibrary.org/obo/GO_0034799 GO:0019159 biolink:MolecularActivity nicotinamide-nucleotide amidase activity Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3. EC:3.5.1.42|MetaCyc:NMNAMIDOHYDRO-RXN|RHEA:12400 go.json NMN amidohydrolase|NMN deamidase activity|nicotinamide mononucleotide amidohydrolase activity|nicotinamide mononucleotide deamidase activity|nicotinamide-D-ribonucleotide amidohydrolase activity http://purl.obolibrary.org/obo/GO_0019159 GO:0019157 biolink:MolecularActivity obsolete malate oxidase activity OBSOLETE. Catalysis of the reaction: (S)-malate + O2 = H2O2 + oxaloacetate. go.json (S)-malate:oxygen oxidoreductase activity|FAD-dependent malate oxidase activity|malic dehydrogenase II|malic oxidase activity True http://purl.obolibrary.org/obo/GO_0019157 GO:0019158 biolink:MolecularActivity mannokinase activity Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. EC:2.7.1.7|MetaCyc:MANNKIN-RXN|RHEA:11028 go.json ATP:D-mannose 6-phosphotransferase activity|D-fructose (D-mannose) kinase activity|mannokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0019158 GO:0019155 biolink:MolecularActivity 3-(imidazol-5-yl)lactate dehydrogenase activity Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+. EC:1.1.1.111|MetaCyc:IMILACTDEHYDROG-RXN go.json (S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity|imidazol-5-yl lactate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0019155 GO:0019156 biolink:MolecularActivity isoamylase activity Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. EC:3.2.1.68|MetaCyc:3.2.1.68-RXN|MetaCyc:RXN-12280|MetaCyc:RXN-14380 go.json debranching enzyme activity|glycogen alpha-1,6-glucanohydrolase activity http://purl.obolibrary.org/obo/GO_0019156 GO:0019153 biolink:MolecularActivity protein-disulfide reductase (glutathione) activity Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol. EC:1.8.4.2|MetaCyc:PRODISULFREDUCT-RXN|RHEA:21064 go.json glutaredoxin reductase|glutathione-insulin transhydrogenase activity|insulin reductase activity|protein disulfide reductase (glutathione)|protein disulfide transhydrogenase activity|protein-disulphide reductase (glutathione) activity http://purl.obolibrary.org/obo/GO_0019153 GO:0034790 biolink:MolecularActivity 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-. UM-BBD_reactionID:r1043 go.json http://purl.obolibrary.org/obo/GO_0034790 GO:0019154 biolink:MolecularActivity glycolate dehydrogenase activity Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate. EC:1.1.99.14|KEGG_REACTION:R00476|MetaCyc:GLYCOLATEDEHYDRO-RXN|RHEA:21264 go.json glycolate oxidoreductase activity|glycolate:(acceptor) 2-oxidoreductase activity|glycolate:acceptor 2-oxidoreductase activity|glycolic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0019154 GO:0034791 biolink:MolecularActivity isobutylamine N-hydroxylase activity Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O. EC:1.14.13.-|UM-BBD_reactionID:r1053 go.json http://purl.obolibrary.org/obo/GO_0034791 GO:0019173 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019173 GO:0019174 biolink:MolecularActivity tetrahydrothiophene 1-oxide reductase activity Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor. MetaCyc:THTOREDUCT-RXN go.json http://purl.obolibrary.org/obo/GO_0019174 GO:0019171 biolink:MolecularActivity (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O. EC:4.2.1.59|MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN|RHEA:13097 go.json (3R)-3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity|3-hydroxyacyl-ACP dehydratase activity|3-hydroxyacyl-[acyl-carrier protein] dehydratase activity|3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity http://purl.obolibrary.org/obo/GO_0019171 GO:0019172 biolink:MolecularActivity glyoxalase III activity Catalysis of the reaction: methylglyoxal + H2O = D-lactate. EC:4.2.1.130|MetaCyc:GLYOXIII-RXN|RHEA:27754 go.json (R)-lactate hydro-lyase|D-lactate dehydratase|glutathione-independent glyoxalase activity http://purl.obolibrary.org/obo/GO_0019172 GO:0019170 biolink:MolecularActivity methylglyoxal reductase (NADH-dependent) activity Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+. EC:1.1.1.78|MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN|RHEA:24528 go.json (R)-lactaldehyde:NAD+ oxidoreductase activity|D-lactaldehyde dehydrogenase activity|methylglyoxal reductase activity http://purl.obolibrary.org/obo/GO_0019170 GO:0034789 biolink:MolecularActivity 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+. UM-BBD_reactionID:r1042 go.json http://purl.obolibrary.org/obo/GO_0034789 GO:0034781 biolink:MolecularActivity N-cyclohexylformamide amidohydrolase activity Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate. UM-BBD_reactionID:r1030 go.json http://purl.obolibrary.org/obo/GO_0034781 GO:0034782 biolink:MolecularActivity dimethylmalonate decarboxylase activity Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2. UM-BBD_reactionID:r1031 go.json http://purl.obolibrary.org/obo/GO_0034782 GO:0034783 biolink:MolecularActivity pivalate-CoA ligase activity Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP. UM-BBD_reactionID:r1032 go.json http://purl.obolibrary.org/obo/GO_0034783 GO:0034784 biolink:MolecularActivity pivalyl-CoA mutase activity Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA. EC:5.4.99.-|UM-BBD_reactionID:r1033 go.json http://purl.obolibrary.org/obo/GO_0034784 GO:0034785 biolink:MolecularActivity salicylate 5-hydroxylase activity Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+. EC:1.14.13.172|MetaCyc:RXN-10446|RHEA:35307|UM-BBD_reactionID:r1034 go.json http://purl.obolibrary.org/obo/GO_0034785 GO:0034786 biolink:MolecularActivity 9-fluorenone-3,4-dioxygenase activity Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone. UM-BBD_reactionID:r1039 go.json http://purl.obolibrary.org/obo/GO_0034786 GO:0034787 biolink:MolecularActivity 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-. UM-BBD_reactionID:r1040 go.json http://purl.obolibrary.org/obo/GO_0034787 GO:0034788 biolink:MolecularActivity 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+. UM-BBD_reactionID:r1041 go.json http://purl.obolibrary.org/obo/GO_0034788 GO:0019168 biolink:MolecularActivity 2-octaprenylphenol hydroxylase activity Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O. MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN|RHEA:27790 go.json http://purl.obolibrary.org/obo/GO_0019168 GO:0019166 biolink:MolecularActivity trans-2-enoyl-CoA reductase (NADPH) activity Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. EC:1.3.1.38|MetaCyc:TRANSENOYLCOARED-RXN|RHEA:33763|Reactome:R-HSA-6786720|Reactome:R-HSA-6809810|Reactome:R-HSA-8952873 go.json NADPH-dependent trans-2-enoyl-CoA reductase activity|acyl-CoA:NADP+ trans-2-oxidoreductase activity|reductase, trans-enoyl coenzyme A http://purl.obolibrary.org/obo/GO_0019166 GO:0019167 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019167 GO:0019164 biolink:MolecularActivity pyruvate synthase activity Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. EC:1.2.7.1|KEGG_REACTION:R01196|MetaCyc:PYRUFLAVREDUCT-RXN|RHEA:12765 go.json PFOR|pyruvate oxidoreductase activity|pyruvate synthetase activity|pyruvate-ferredoxin reductase activity|pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)|pyruvate:ferredoxin oxidoreductase activity|pyruvic-ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0019164 GO:0019165 biolink:MolecularActivity thiamine kinase activity Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate. EC:2.7.1.89|KEGG_REACTION:R02134|MetaCyc:THIKIN-RXN|RHEA:12012 go.json ATP:thiamin phosphotransferase activity|ATP:thiamine phosphotransferase activity|thiamin kinase (phosphorylating)|thiamin kinase activity|thiamin phosphokinase activity http://purl.obolibrary.org/obo/GO_0019165 GO:0034780 biolink:MolecularActivity glyphosate dehydrogenase activity Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-. UM-BBD_reactionID:r0073 go.json http://purl.obolibrary.org/obo/GO_0034780 GO:0019140 biolink:MolecularActivity inositol 3-kinase activity Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate. EC:2.7.1.64|MetaCyc:MYO-INOSITOL-1-KINASE-RXN|RHEA:21804 go.json ATP:myo-inositol 1-phosphotransferase activity|inositol 1-kinase activity|inositol-1-kinase (phosphorylating)|myo-inositol 1-kinase activity|myo-inositol 3-kinase activity|myoinositol kinase activity http://purl.obolibrary.org/obo/GO_0019140 GO:0019141 biolink:MolecularActivity 2-dehydropantolactone reductase (B-specific) activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. EC:1.1.1.214|MetaCyc:1.1.1.209-RXN go.json (R)-pantolactone:NADP+ oxidoreductase (B-specific)|2-dehydropantoyl-lactone reductase (B-specific) activity|2-ketopantoyl lactone reductase activity|2-oxopantoyl lactone reductase|ketopantoyl lactone reductase activity http://purl.obolibrary.org/obo/GO_0019141 GO:0034778 biolink:MolecularActivity 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-. UM-BBD_reactionID:r1003 go.json http://purl.obolibrary.org/obo/GO_0034778 GO:0034779 biolink:MolecularActivity 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA. UM-BBD_reactionID:r1004 go.json http://purl.obolibrary.org/obo/GO_0034779 GO:0034770 biolink:BiologicalProcess histone H4-K20 methylation The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone. go.json histone H4 K20 methylation|histone H4K20me|histone lysine H4 K20 methylation http://purl.obolibrary.org/obo/GO_0034770 gocheck_do_not_annotate GO:0034771 biolink:BiologicalProcess obsolete histone H4-K20 monomethylation OBSOLETE. The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone. go.json histone H4 K20 monomethylation|histone lysine H4 K20 monomethylation True http://purl.obolibrary.org/obo/GO_0034771 GO:0034772 biolink:BiologicalProcess histone H4-K20 dimethylation The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone. go.json histone H4 K20 dimethylation|histone lysine H4 K20 dimethylation http://purl.obolibrary.org/obo/GO_0034772 gocheck_do_not_annotate GO:0034773 biolink:BiologicalProcess histone H4-K20 trimethylation The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone. go.json histone H4 K20 trimethylation|histone lysine H4 K20 trimethylation http://purl.obolibrary.org/obo/GO_0034773 gocheck_do_not_annotate GO:0034774 biolink:CellularComponent secretory granule lumen The volume enclosed by the membrane of a secretory granule. go.json http://purl.obolibrary.org/obo/GO_0034774 GO:0034775 biolink:BiologicalProcess glutathione transmembrane transport A process in which glutathione is transported across a membrane. go.json glutathione membrane transport|transmembrane glutathione transport http://purl.obolibrary.org/obo/GO_0034775 GO:0034776 biolink:BiologicalProcess response to histamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. go.json response to histamine stimulus http://purl.obolibrary.org/obo/GO_0034776 GO:0019139 biolink:MolecularActivity cytokinin dehydrogenase activity Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. EC:1.5.99.12|MetaCyc:1.5.99.12-RXN|MetaCyc:PWY-2841|RHEA:13625 go.json 6-N-dimethylallyladenine:acceptor oxidoreductase activity|N6-dimethylallyladenine:(acceptor) oxidoreductase activity|N6-dimethylallyladenine:acceptor oxidoreductase activity|cytokinin oxidase activity http://purl.obolibrary.org/obo/GO_0019139 GO:0034777 biolink:CellularComponent recycling endosome lumen The volume enclosed by the membranes of a recycling endosome. go.json http://purl.obolibrary.org/obo/GO_0034777 GO:0019137 biolink:MolecularActivity thioglucosidase activity Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar. EC:3.2.1.147|MetaCyc:RXN-9946 go.json myrosinase activity|sinigrase activity|sinigrinase activity|thioglucoside glucohydrolase activity http://purl.obolibrary.org/obo/GO_0019137 GO:0019138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019138 GO:0019135 biolink:MolecularActivity deoxyhypusine monooxygenase activity Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. EC:1.14.99.29|MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN|RHEA:14101|Reactome:R-HSA-204662 go.json DOHH activity|deoxyhypusine dioxygenase activity|deoxyhypusine hydroxylase activity|deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating) http://purl.obolibrary.org/obo/GO_0019135 GO:0019136 biolink:MolecularActivity deoxynucleoside kinase activity Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. EC:2.7.1.145|MetaCyc:2.7.1.145-RXN|RHEA:12140|Reactome:R-HSA-74207 go.json ATP:deoxynucleoside 5'-phosphotransferase activity|D. melanogaster deoxynucleoside kinase activity|Dm-dNK|Ms-dNK activity|ms-dNK|multifunctional deoxynucleoside kinase activity|multispecific deoxynucleoside kinase activity|multisubstrate deoxyribonucleoside kinase activity http://purl.obolibrary.org/obo/GO_0019136 GO:0019133 biolink:MolecularActivity choline monooxygenase activity Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O. EC:1.14.15.7|MetaCyc:RXN1F-357|RHEA:17769 go.json choline,reduced-ferredoxin:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0019133 GO:0019134 biolink:MolecularActivity glucosamine-1-phosphate N-acetyltransferase activity Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H+. EC:2.3.1.157|KEGG_REACTION:R05332|MetaCyc:2.3.1.157-RXN|RHEA:13725 go.json acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity|acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0019134 GO:0019131 biolink:MolecularActivity obsolete tripeptidyl-peptidase I activity OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH. go.json tripeptidyl aminopeptidase activity|tripeptidyl peptidase activity|tripeptidyl-peptidase I activity True http://purl.obolibrary.org/obo/GO_0019131 GO:0019132 biolink:MolecularActivity obsolete C-terminal processing peptidase activity OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. go.json C-terminal processing peptidase activity|CtpA gene product (Synechocystis sp.)|Tsp protease|photosystem II D1 protein processing peptidase|protease Re|tail-specific protease activity True http://purl.obolibrary.org/obo/GO_0019132 GO:0019151 biolink:MolecularActivity galactose 1-dehydrogenase activity Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+. EC:1.1.1.48|MetaCyc:GALACTODEHYDROG-RXN|RHEA:21296 go.json D-galactose 1-dehydrogenase activity|D-galactose dehydrogenase activity|D-galactose:NAD+ 1-oxidoreductase activity|NAD-dependent D-galactose dehydrogenase activity|beta-galactose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0019151 GO:0019152 biolink:MolecularActivity acetoin dehydrogenase activity Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. EC:1.1.1.303|EC:1.1.1.304|KEGG_REACTION:R02343|MetaCyc:ACETOINDEHYDROG-RXN go.json diacetyl reductase activity http://purl.obolibrary.org/obo/GO_0019152 GO:0019150 biolink:MolecularActivity D-ribulokinase activity Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate. EC:2.7.1.47|MetaCyc:D-RIBULOKIN-RXN|RHEA:17601 go.json ATP:D-ribulose 5-phosphotransferase activity|D-ribulokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0019150 GO:0034767 biolink:BiologicalProcess positive regulation of monoatomic ion transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. go.json activation of transmembrane ion transport|positive regulation of ion membrane transport|positive regulation of ion transmembrane transport|positive regulation of transmembrane ion transport|stimulation of transmembrane ion transport|up regulation of transmembrane ion transport|up-regulation of transmembrane ion transport|upregulation of transmembrane ion transport http://purl.obolibrary.org/obo/GO_0034767 GO:0034768 biolink:MolecularActivity (E)-beta-ocimene synthase activity Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate. EC:4.2.3.106|MetaCyc:RXN-5109|RHEA:32691 go.json http://purl.obolibrary.org/obo/GO_0034768 GO:0034769 biolink:BiologicalProcess basement membrane disassembly The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. go.json basal lamina disassembly http://purl.obolibrary.org/obo/GO_0034769 GO:0034760 biolink:BiologicalProcess negative regulation of iron ion transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json down regulation of transmembrane iron ion transport|down-regulation of transmembrane iron ion transport|downregulation of transmembrane iron ion transport|inhibition of transmembrane iron ion transport|negative regulation of iron ion membrane transport|negative regulation of transmembrane iron ion transport|negative regulation of transmembrane iron transport http://purl.obolibrary.org/obo/GO_0034760 GO:0034761 biolink:BiologicalProcess positive regulation of iron ion transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json activation of transmembrane iron ion transport|positive regulation of iron ion membrane transport|positive regulation of transmembrane iron ion transport|positive regulation of transmembrane iron transport|stimulation of transmembrane iron ion transport|up regulation of transmembrane iron ion transport|up-regulation of transmembrane iron ion transport|upregulation of transmembrane iron ion transport http://purl.obolibrary.org/obo/GO_0034761 GO:0034762 biolink:BiologicalProcess regulation of transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. go.json regulation of membrane transport http://purl.obolibrary.org/obo/GO_0034762 GO:0034763 biolink:BiologicalProcess negative regulation of transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. go.json down regulation of transmembrane transport|down-regulation of transmembrane transport|downregulation of transmembrane transport|inhibition of transmembrane transport|negative regulation of membrane transport http://purl.obolibrary.org/obo/GO_0034763 GO:0034764 biolink:BiologicalProcess positive regulation of transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. go.json activation of transmembrane transport|positive regulation of membrane transport|stimulation of transmembrane transport|up regulation of transmembrane transport|up-regulation of transmembrane transport|upregulation of transmembrane transport http://purl.obolibrary.org/obo/GO_0034764 GO:0034765 biolink:BiologicalProcess regulation of monoatomic ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. go.json regulation of ion membrane transport|regulation of ion transmembrane transport|regulation of transmembrane ion transport http://purl.obolibrary.org/obo/GO_0034765 GO:0034766 biolink:BiologicalProcess negative regulation of monoatomic ion transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. go.json down regulation of transmembrane ion transport|down-regulation of transmembrane ion transport|downregulation of transmembrane ion transport|inhibition of transmembrane ion transport|negative regulation of ion membrane transport|negative regulation of ion transmembrane transport|negative regulation of transmembrane ion transport http://purl.obolibrary.org/obo/GO_0034766 GO:0019148 biolink:MolecularActivity D-cysteine desulfhydrase activity Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate. EC:4.4.1.15|MetaCyc:DCYSDESULF-RXN|RHEA:11268 go.json D-cysteine lyase activity|D-cysteine sulfide-lyase (deaminating)|D-cysteine sulfide-lyase (deaminating; pyruvate-forming) http://purl.obolibrary.org/obo/GO_0019148 GO:0019149 biolink:MolecularActivity 3-chloro-D-alanine dehydrochlorinase activity Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3. EC:4.5.1.2|MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN|RHEA:18873 go.json 3-chloro-D-alanine chloride-lyase (deaminating)|3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)|beta-chloro-D-alanine dehydrochlorinase activity http://purl.obolibrary.org/obo/GO_0019149 GO:0019146 biolink:MolecularActivity arabinose-5-phosphate isomerase activity Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H+. EC:5.3.1.13|KEGG_REACTION:R01530|MetaCyc:DARAB5PISOM-RXN|RHEA:23104 go.json D-arabinose-5-phosphate aldose-ketose-isomerase activity|D-arabinose-5-phosphate ketol-isomerase activity|arabinose phosphate isomerase activity|phosphoarabinoisomerase activity http://purl.obolibrary.org/obo/GO_0019146 GO:0019147 biolink:MolecularActivity (R)-aminopropanol dehydrogenase activity Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + H+ + NADH. EC:1.1.1.75|KEGG_REACTION:R03759|MetaCyc:AMINOPROPDEHYDROG-RXN|RHEA:16517 go.json (R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity|1-aminopropan-2-ol-NAD+ dehydrogenase activity|1-aminopropan-2-ol-dehydrogenase activity|DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity|L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity|L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity|L-aminopropanol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0019147 GO:0019144 biolink:MolecularActivity ADP-sugar diphosphatase activity Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. EC:3.6.1.21|MetaCyc:ADPSUGPPHOSPHAT-RXN go.json ADP-sugar pyrophosphatase activity|ADP-sugar sugarphosphohydrolase activity|ADPsugar pyrophosphatase activity|adenosine diphosphosugar pyrophosphatase activity|nucleoside diphosphate-sugar hydrolase activity http://purl.obolibrary.org/obo/GO_0019144 GO:0019145 biolink:MolecularActivity aminobutyraldehyde dehydrogenase activity Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. EC:1.2.1.19|MetaCyc:AMINOBUTDEHYDROG-RXN|RHEA:19105 go.json 4-aminobutanal dehydrogenase activity|4-aminobutanal:NAD+ 1-oxidoreductase activity|4-aminobutyraldehyde dehydrogenase activity|ABAL dehydrogenase activity|gamma-aminobutyraldehyde dehydroganase activity http://purl.obolibrary.org/obo/GO_0019145 GO:0019142 biolink:MolecularActivity 2-hydroxyglutarate synthase activity Catalysis of the reaction: glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H+. EC:2.3.3.11|KEGG_REACTION:R00932|MetaCyc:HYDGLUTSYN-RXN|RHEA:19185 go.json 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity|2-hydroxyglutaratic synthetase activity|2-hydroxyglutaric synthetase activity|alpha-hydroxyglutarate synthase activity|hydroxyglutarate synthase activity|propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming) http://purl.obolibrary.org/obo/GO_0019142 GO:0019143 biolink:MolecularActivity 3-deoxy-manno-octulosonate-8-phosphatase activity Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. EC:3.1.3.45|KEGG_REACTION:R03350|MetaCyc:KDO-8PPHOSPHAT-RXN|RHEA:11500 go.json 3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0019143 GO:0010789 biolink:BiologicalProcess meiotic sister chromatid cohesion involved in meiosis I The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I. go.json http://purl.obolibrary.org/obo/GO_0010789 GO:0034756 biolink:BiologicalProcess regulation of iron ion transport Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of Fe transport|regulation of iron import|regulation of iron ion import|regulation of iron transport http://purl.obolibrary.org/obo/GO_0034756 GO:0034757 biolink:BiologicalProcess negative regulation of iron ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of iron ion transport|down-regulation of iron ion transport|downregulation of iron ion transport|inhibition of iron ion transport|negative regulation of iron transport http://purl.obolibrary.org/obo/GO_0034757 GO:0034758 biolink:BiologicalProcess positive regulation of iron ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of iron ion transport|positive regulation of iron transport|stimulation of iron ion transport|up regulation of iron ion transport|up-regulation of iron ion transport|upregulation of iron ion transport http://purl.obolibrary.org/obo/GO_0034758 GO:0010787 biolink:BiologicalProcess COPI coating of Golgi vesicle, inter-Golgi cisterna The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat. go.json http://purl.obolibrary.org/obo/GO_0010787 GO:0010788 biolink:BiologicalProcess COPI coating of Golgi vesicle, cis-Golgi to rough ER The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat. go.json http://purl.obolibrary.org/obo/GO_0010788 GO:0034759 biolink:BiologicalProcess regulation of iron ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json regulation of iron ion membrane transport|regulation of transmembrane Fe transport|regulation of transmembrane iron ion transport|regulation of transmembrane iron transport http://purl.obolibrary.org/obo/GO_0034759 GO:0009792 biolink:BiologicalProcess embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. go.json embryogenesis http://purl.obolibrary.org/obo/GO_0009792 GO:0010781 biolink:BiologicalProcess meiotic DNA double-strand break formation involved in meiotic gene conversion The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. go.json http://purl.obolibrary.org/obo/GO_0010781 GO:0009793 biolink:BiologicalProcess embryo development ending in seed dormancy The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. go.json embryogenesis http://purl.obolibrary.org/obo/GO_0009793 GO:0010782 biolink:BiologicalProcess proboscis morphogenesis, labial disc-derived The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0010782 GO:0009794 biolink:BiologicalProcess regulation of mitotic cell cycle, embryonic Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo. go.json embryonic mitotic cell cycle modulation|embryonic mitotic cell cycle regulation|embryonic mitotic cell cycle regulator|modulation of embryonic mitotic cell cycle progression|regulation of embryonic mitotic cell cycle|regulation of embryonic mitotic cell cycle progression|regulation of progression through embryonic mitotic cell cycle http://purl.obolibrary.org/obo/GO_0009794 GO:0034750 biolink:CellularComponent Scrib-APC-beta-catenin complex A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation. go.json hScrib-APC-beta-catenin complex http://purl.obolibrary.org/obo/GO_0034750 GO:0034751 biolink:CellularComponent aryl hydrocarbon receptor complex A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR. go.json AHRC|AhR complex http://purl.obolibrary.org/obo/GO_0034751 GO:0010780 biolink:BiologicalProcess meiotic DNA double-strand break formation involved in reciprocal meiotic recombination The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json http://purl.obolibrary.org/obo/GO_0010780 GO:0009795 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009795 GO:0019119 biolink:MolecularActivity phenanthrene-9,10-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. go.json http://purl.obolibrary.org/obo/GO_0019119 GO:0034752 biolink:CellularComponent cytosolic aryl hydrocarbon receptor complex An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP. go.json 9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex|cytosolic AHRC|cytosolic AhR complex http://purl.obolibrary.org/obo/GO_0034752 GO:0009796 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009796 GO:0010785 biolink:BiologicalProcess clathrin coating of Golgi vesicle, plasma membrane to endosome targeting The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat. go.json http://purl.obolibrary.org/obo/GO_0010785 GO:0034753 biolink:CellularComponent nuclear aryl hydrocarbon receptor complex An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT). go.json 6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex|nuclear AHRC|nuclear AhR complex http://purl.obolibrary.org/obo/GO_0034753 GO:0009797 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009797 GO:0010786 biolink:BiologicalProcess clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat. go.json http://purl.obolibrary.org/obo/GO_0010786 GO:0034754 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034754 GO:0009798 biolink:BiologicalProcess axis specification The establishment, maintenance and elaboration of a pattern along a line or around a point. go.json axis determination http://purl.obolibrary.org/obo/GO_0009798 GO:0019117 biolink:MolecularActivity dihydroxyfluorene dioxygenase activity Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid. EC:1.13.11.- go.json http://purl.obolibrary.org/obo/GO_0019117 GO:0010783 biolink:BiologicalProcess proboscis morphogenesis, eye-antennal disc-derived The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0010783 GO:0019118 biolink:MolecularActivity phenanthrene-epoxide hydrolase activity Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene. EC:3.3.2.- go.json http://purl.obolibrary.org/obo/GO_0019118 GO:0034755 biolink:BiologicalProcess iron ion transmembrane transport A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json ferrous ion transmembrane transport|ferrous iron transmembrane transport|high affinity ferrous ion transmembrane transport|high affinity iron ion transport|high-affinity ferrous ion transmembrane transport|high-affinity iron ion transmembrane transport|high-affinity iron ion transport|iron ion membrane transport|iron(2+) transmembrane transport|low affinity iron ion transport|low-affinity iron ion transmembrane transport|low-affinity iron ion transport|transmembrane iron transport http://purl.obolibrary.org/obo/GO_0034755 GO:0010784 biolink:BiologicalProcess proboscis morphogenesis, clypeo-labral disc-derived The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0010784 GO:0009799 biolink:BiologicalProcess specification of symmetry The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. go.json determination of symmetry http://purl.obolibrary.org/obo/GO_0009799 GO:0019115 biolink:MolecularActivity benzaldehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+. EC:1.2.1.- go.json http://purl.obolibrary.org/obo/GO_0019115 GO:0019116 biolink:MolecularActivity hydroxy-nicotine oxidase activity Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide. EC:1.5.3.6 go.json http://purl.obolibrary.org/obo/GO_0019116 GO:0019113 biolink:MolecularActivity limonene monooxygenase activity Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene. EC:1.14.13.- go.json http://purl.obolibrary.org/obo/GO_0019113 GO:0019114 biolink:MolecularActivity catechol dioxygenase activity Catalysis of the reaction: catechol + O2 = a muconate. EC:1.13.11.- go.json http://purl.obolibrary.org/obo/GO_0019114 GO:0019111 biolink:MolecularActivity phenanthrol sulfotransferase activity Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate. go.json phenanthrol sulphotransferase activity http://purl.obolibrary.org/obo/GO_0019111 GO:0019112 biolink:MolecularActivity phenanthrol glycosyltransferase activity Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O. go.json http://purl.obolibrary.org/obo/GO_0019112 GO:0019110 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019110 GO:0019130 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019130 GO:0034745 biolink:CellularComponent APC-IQGAP1-Rac1 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. go.json http://purl.obolibrary.org/obo/GO_0034745 GO:0034746 biolink:CellularComponent APC-IQGAP1-CLIP-170 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration. go.json http://purl.obolibrary.org/obo/GO_0034746 GO:0010798 biolink:BiologicalProcess regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin. go.json http://purl.obolibrary.org/obo/GO_0010798 GO:0034747 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034747 GO:0034748 biolink:CellularComponent Par3-APC-KIF3A complex A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity. go.json http://purl.obolibrary.org/obo/GO_0034748 GO:0010799 biolink:BiologicalProcess regulation of peptidyl-threonine phosphorylation Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. go.json http://purl.obolibrary.org/obo/GO_0010799 GO:0034749 biolink:CellularComponent Scrib-APC complex A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation. go.json hScrib-APC complex http://purl.obolibrary.org/obo/GO_0034749 GO:0010792 biolink:BiologicalProcess DNA double-strand break processing involved in repair via single-strand annealing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing. go.json http://purl.obolibrary.org/obo/GO_0010792 GO:0010793 biolink:BiologicalProcess regulation of mRNA export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0010793 GO:0010790 biolink:BiologicalProcess meiotic sister chromatid cohesion involved in meiosis II The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II. go.json http://purl.obolibrary.org/obo/GO_0010790 GO:0010791 biolink:BiologicalProcess DNA double-strand break processing involved in repair via synthesis-dependent strand annealing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing. go.json http://purl.obolibrary.org/obo/GO_0010791 GO:0034740 biolink:CellularComponent TFIIIC-TOP1-SUB1 complex A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III. go.json TFIIIC-Topoisomerase 1-PC4 complex http://purl.obolibrary.org/obo/GO_0034740 GO:0010796 biolink:BiologicalProcess regulation of multivesicular body size Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles. go.json http://purl.obolibrary.org/obo/GO_0010796 GO:0034741 biolink:CellularComponent APC-tubulin-IQGAP1 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization. go.json 60S APC complex http://purl.obolibrary.org/obo/GO_0034741 GO:0034742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034742 GO:0010797 biolink:BiologicalProcess regulation of multivesicular body size involved in endosome transport Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles. go.json http://purl.obolibrary.org/obo/GO_0010797 GO:0019128 biolink:BiologicalProcess peptidyl-tryptophan racemization The racemization of peptidyl-tryptophan. RESID:AA0198 go.json http://purl.obolibrary.org/obo/GO_0019128 gocheck_do_not_annotate GO:0034743 biolink:CellularComponent APC-IQGAP complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. go.json http://purl.obolibrary.org/obo/GO_0034743 GO:0010794 biolink:BiologicalProcess regulation of dolichol biosynthetic process Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. go.json http://purl.obolibrary.org/obo/GO_0010794 GO:0010795 biolink:BiologicalProcess regulation of ubiquinone biosynthetic process Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. go.json http://purl.obolibrary.org/obo/GO_0010795 GO:0019129 biolink:BiologicalProcess peptidyl-leucine racemization The racemization of peptidyl-leucine. RESID:AA0197 go.json http://purl.obolibrary.org/obo/GO_0019129 gocheck_do_not_annotate GO:0034744 biolink:CellularComponent APC-IQGAP1-Cdc42 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. go.json http://purl.obolibrary.org/obo/GO_0034744 GO:0019126 biolink:BiologicalProcess peptidyl-serine racemization The racemization of peptidyl-serine. RESID:AA0195 go.json http://purl.obolibrary.org/obo/GO_0019126 gocheck_do_not_annotate GO:0019127 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019127 GO:0019124 biolink:BiologicalProcess peptidyl-isoleucine racemization The racemization of peptidyl-isoleucine. RESID:AA0192 go.json http://purl.obolibrary.org/obo/GO_0019124 gocheck_do_not_annotate GO:0019125 biolink:BiologicalProcess peptidyl-phenylalanine racemization The racemization of peptidyl-phenylalanine. RESID:AA0194 go.json http://purl.obolibrary.org/obo/GO_0019125 gocheck_do_not_annotate GO:0019122 biolink:BiologicalProcess peptidyl-D-alanine racemization The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine. RESID:AA0191 go.json alanine racemization http://purl.obolibrary.org/obo/GO_0019122 gocheck_do_not_annotate GO:0019123 biolink:BiologicalProcess peptidyl-methionine racemization The racemization of peptidyl-methionine. RESID:AA0193 go.json http://purl.obolibrary.org/obo/GO_0019123 gocheck_do_not_annotate GO:0019120 biolink:MolecularActivity hydrolase activity, acting on acid halide bonds, in C-halide compounds Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage. EC:3.8.1.-|Reactome:R-HSA-9011595 go.json http://purl.obolibrary.org/obo/GO_0019120 GO:0019121 biolink:BiologicalProcess peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan. RESID:AA0218 go.json http://purl.obolibrary.org/obo/GO_0019121 gocheck_do_not_annotate GO:0019098 biolink:BiologicalProcess reproductive behavior The specific behavior of an organism that is associated with reproduction. go.json multi-organism reproductive behavior|multicellular organism reproductive behavior|reproductive behavior in a multicellular organism|reproductive behaviour|single-organism reproductive behavior http://purl.obolibrary.org/obo/GO_0019098 GO:0019099 biolink:BiologicalProcess female germ-line sex determination The determination of sex and sexual phenotype in a female organism's germ line. go.json sex determination, female germ-line determination http://purl.obolibrary.org/obo/GO_0019099 GO:0019085 biolink:BiologicalProcess early viral transcription The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell. go.json immediate early viral mRNA transcription http://purl.obolibrary.org/obo/GO_0019085 GO:0019086 biolink:BiologicalProcess late viral transcription The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins. go.json late viral mRNA transcription http://purl.obolibrary.org/obo/GO_0019086 GO:0019083 biolink:BiologicalProcess viral transcription The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. go.json http://purl.obolibrary.org/obo/GO_0019083 GO:0019084 biolink:BiologicalProcess middle viral transcription The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication. go.json (delayed) early viral mRNA transcription http://purl.obolibrary.org/obo/GO_0019084 GO:0019081 biolink:BiologicalProcess viral translation A process by which viral mRNA is translated into viral protein, using the host cellular machinery. go.json viral protein anabolism|viral protein biosynthesis|viral protein biosynthetic process|viral protein formation|viral protein synthesis http://purl.obolibrary.org/obo/GO_0019081 GO:0019082 biolink:BiologicalProcess viral protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. go.json http://purl.obolibrary.org/obo/GO_0019082 GO:0019080 biolink:BiologicalProcess viral gene expression A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation. go.json viral genome expression http://purl.obolibrary.org/obo/GO_0019080 GO:0019078 biolink:BiologicalProcess obsolete lytic viral budding OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment. go.json lytic viral budding True http://purl.obolibrary.org/obo/GO_0019078 GO:0019079 biolink:BiologicalProcess viral genome replication Any process involved directly in viral genome replication, including viral nucleotide metabolism. go.json sigma virus replication|viral replication http://purl.obolibrary.org/obo/GO_0019079 GO:0019076 biolink:BiologicalProcess viral release from host cell The dissemination of mature viral particles from a host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. VZ:1076 go.json release of virus from host|viral exit|viral release|viral shedding|virus exit from host cell http://purl.obolibrary.org/obo/GO_0019076 GO:0019077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019077 GO:0019096 biolink:BiologicalProcess pole plasm mitochondrial lrRNA localization Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. go.json establishment and maintenance of mitochondrial lrRNA localization in pole plasm|oocyte pole plasm mitochondrial lrRNA localization|pole plasm mitochondrial lrRNA localisation http://purl.obolibrary.org/obo/GO_0019096 GO:0019097 biolink:BiologicalProcess pole plasm mitochondrial srRNA localization Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. go.json establishment and maintenance of mitochondrial localization in pole plasm|oocyte pole plasm mitochondrial srRNA localization|pole plasm mitochondrial srRNA localisation http://purl.obolibrary.org/obo/GO_0019097 GO:0019094 biolink:BiologicalProcess pole plasm mRNA localization Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. go.json establishment and maintenance of mRNA localization in pole plasm|establishment and maintenance of pole plasm mRNA localization|oocyte pole plasm mRNA localization|pole granule RNA localization|pole plasm mRNA localisation http://purl.obolibrary.org/obo/GO_0019094 GO:0019095 biolink:BiologicalProcess pole plasm mitochondrial rRNA localization Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. go.json establishment and maintenance of mitochondrial rRNA localization in pole plasm|oocyte pole plasm mitochondrial rRNA localization|pole plasm mitochondrial rRNA localisation http://purl.obolibrary.org/obo/GO_0019095 GO:0019092 biolink:BiologicalProcess mitochondrial srRNA export from mitochondrion The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. go.json export of mitochondrial srRNA|mitochondrial srRNA export|mitochondrial srRNA export from mitochondria|mitochondrial srRNA export out of mitochondrion|mitochondrial srRNA transport from mitochondrion|mitochondrial srRNA, mitochondrial export http://purl.obolibrary.org/obo/GO_0019092 GO:0019093 biolink:BiologicalProcess mitochondrial RNA localization Any process in which mitochondrial RNA is transported to, or maintained in, a specific location. go.json establishment and maintenance of mitochondrial RNA localization|mitochondrial RNA localisation|mtRNA localization http://purl.obolibrary.org/obo/GO_0019093 GO:0019090 biolink:BiologicalProcess mitochondrial rRNA export from mitochondrion The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. go.json export of mitochondrial rRNA|mitochondrial rRNA export|mitochondrial rRNA export from mitochondria|mitochondrial rRNA export out of mitochondrion|mitochondrial rRNA transport from mitochondrion|mitochondrial rRNA, mitochondrial export http://purl.obolibrary.org/obo/GO_0019090 GO:0019091 biolink:BiologicalProcess mitochondrial lrRNA export from mitochondrion The process in which a lrRNA, large subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. go.json export of mitochondrial lrRNA|mitochondrial lrRNA export|mitochondrial lrRNA export from mitochondria|mitochondrial lrRNA export out of mitochondrion|mitochondrial lrRNA transport from mitochondrion|mitochondrial lrRNA, mitochondrial export http://purl.obolibrary.org/obo/GO_0019091 GO:0019089 biolink:BiologicalProcess obsolete transmission of virus OBSOLETE. The transfer of virions in order to create new infection. go.json viral transmission True http://purl.obolibrary.org/obo/GO_0019089 GO:0019087 biolink:BiologicalProcess transformation of host cell by virus A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. Wikipedia:Viral_transformation go.json host cell immortalization|host cell transformation|immortalization of host cell|immortalization of host cell by virus|transformation of host cell|viral immortalization|viral transformation|viral transformation of host cell http://purl.obolibrary.org/obo/GO_0019087 GO:0019088 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019088 GO:0044020 biolink:MolecularActivity histone H4R3 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me. go.json histone H4KR3 methylation|histone H4R3 arginine methylase activity|histone methylase activity (H4-R3 specific)|histone methyltransferase activity (H4-R3 specific)|histone-arginine N-methyltransferase activity (H4-R3 specific) http://purl.obolibrary.org/obo/GO_0044020 GO:0044027 biolink:BiologicalProcess negative regulation of gene expression via CpG island methylation An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. go.json DNA hypermethylation of CpG island|epigenetic regulation of gene expression via CpG island hypermethylation|hypermethylation of CpG island|maintenance of DNA methylation|negative regulation of gene expression via CpG island hypermethylation|negative regulation of gene expression via chromosomal DNA cytosine methylation http://purl.obolibrary.org/obo/GO_0044027 GO:0044028 biolink:BiologicalProcess obsolete DNA hypomethylation OBSOLETE. An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA. go.json True http://purl.obolibrary.org/obo/GO_0044028 GO:0044025 biolink:MolecularActivity histone H2BS14 kinase activity Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B. go.json histone kinase activity (H2B-S14 specific)|histone serine kinase activity (H2B-S14 specific)|histone-serine kinase activity (H2B-S14 specific) http://purl.obolibrary.org/obo/GO_0044025 GO:0044026 biolink:BiologicalProcess obsolete DNA hypermethylation OBSOLETE. An increase in the epigenetic methylation of cytosine and adenosine residues in DNA. go.json True http://purl.obolibrary.org/obo/GO_0044026 GO:0044023 biolink:MolecularActivity histone H4S1 kinase activity Catalysis of the reaction: histone H4-serine (position 1) + ATP = histone H4-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H4. go.json histone kinase activity (H4-S1 specific)|histone serine kinase activity (H4-S1 specific)|histone-serine kinase activity (H4-S1 specific) http://purl.obolibrary.org/obo/GO_0044023 GO:0044024 biolink:MolecularActivity histone H2AS1 kinase activity Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A. go.json histone kinase activity (H2A-S1 specific)|histone serine kinase activity (H2A-S1 specific)|histone-serine kinase activity (H2A-S1 specific) http://purl.obolibrary.org/obo/GO_0044024 GO:0044021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044021 GO:0044022 biolink:MolecularActivity histone H3S28 kinase activity Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. go.json histone kinase activity (H3-S28 specific)|histone serine kinase activity (H3-S28 specific)|histone-serine kinase activity (H3-S28 specific) http://purl.obolibrary.org/obo/GO_0044022 GO:0044029 biolink:BiologicalProcess positive regulation of gene expression via CpG island demethylation An epigenetic gene regulation mechanism that positively regulates gene expression by demethylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. go.json DNA hypomethylation of CpG island|hypomethylation of CpG island http://purl.obolibrary.org/obo/GO_0044029 GO:0009709 biolink:BiologicalProcess terpenoid indole alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate). go.json terpenoid indole alkaloid anabolism|terpenoid indole alkaloid biosynthesis|terpenoid indole alkaloid formation|terpenoid indole alkaloid synthesis http://purl.obolibrary.org/obo/GO_0009709 GO:0044030 biolink:BiologicalProcess regulation of DNA methylation Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. go.json http://purl.obolibrary.org/obo/GO_0044030 GO:0044031 biolink:BiologicalProcess obsolete modification by symbiont of host protein by phosphorylation OBSOLETE. The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044031 GO:0044038 biolink:BiologicalProcess cell wall macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall. go.json cell wall macromolecule anabolism|cell wall macromolecule biosynthesis|cell wall macromolecule biosynthetic process at cellular level|cell wall macromolecule synthesis|cellular cell wall macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0044038 GO:0044039 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044039 GO:0044036 biolink:BiologicalProcess cell wall macromolecule metabolic process The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. go.json cellular cell wall macromolecule metabolic process|cellular cell wall macromolecule metabolism http://purl.obolibrary.org/obo/GO_0044036 GO:0044037 biolink:BiologicalProcess obsolete multi-organism cell wall macromolecule metabolic process OBSOLETE. The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. go.json multi-organism cell wall macromolecule metabolism True http://purl.obolibrary.org/obo/GO_0044037 GO:0044034 biolink:BiologicalProcess obsolete multi-organism biosynthetic process OBSOLETE. A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism. go.json multi-organism biosynthesis|multi-organismal biosynthesis|multi-organismal biosynthetic process True http://purl.obolibrary.org/obo/GO_0044034 GO:0044035 biolink:BiologicalProcess obsolete multi-organism catabolic process OBSOLETE. A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism. go.json multi-organism catabolism|multi-organismal catabolic process|multi-organismal catabolism True http://purl.obolibrary.org/obo/GO_0044035 GO:0044032 biolink:BiologicalProcess modulation by symbiont of indole acetic acid levels in host The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of IAA levels in host|modulation by symbiont of auxin levels in host http://purl.obolibrary.org/obo/GO_0044032 GO:0044033 biolink:BiologicalProcess obsolete multi-organism metabolic process OBSOLETE. A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. go.json multi-organism metabolism|multi-organismal metabolic process|multi-organismal metabolism True http://purl.obolibrary.org/obo/GO_0044033 GO:0009700 biolink:BiologicalProcess indole phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response. go.json indole phytoalexin anabolism|indole phytoalexin biosynthesis|indole phytoalexin formation|indole phytoalexin synthesis http://purl.obolibrary.org/obo/GO_0009700 GO:0009701 biolink:BiologicalProcess isoflavonoid phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. go.json isoflavonoid phytoalexin anabolism|isoflavonoid phytoalexin biosynthesis|isoflavonoid phytoalexin formation|isoflavonoid phytoalexin synthesis http://purl.obolibrary.org/obo/GO_0009701 GO:0009702 biolink:MolecularActivity L-arabinokinase activity Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+. EC:2.7.1.46|KEGG_REACTION:R01754|MetaCyc:L-ARABINOKINASE-RXN|RHEA:20153 go.json ATP:L-arabinose 1-phosphotransferase activity|L-arabinokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0009702 GO:0009703 biolink:MolecularActivity nitrate reductase (NADH) activity Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+. EC:1.7.1.1|MetaCyc:NITRATE-REDUCTASE-NADH-RXN|RHEA:17913 go.json NADH-dependent nitrate reductase activity|NADH-nitrate reductase activity|NADH:nitrate oxidoreductase activity|NADH:nitrate reductase activity|assimilatory NADH: nitrate reductase activity|assimilatory NADH:nitrate reductase activity|assimilatory nitrate reductase activity|nitrate reductase (NADH(2)) activity|nitrate reductase (NADH2)|nitrite:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0009703 GO:0009704 biolink:BiologicalProcess de-etiolation The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll. go.json http://purl.obolibrary.org/obo/GO_0009704 GO:0009705 biolink:CellularComponent plant-type vacuole membrane The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. go.json membrane of vacuole with cell cycle-independent morphology|tonoplast|vacuolar membrane http://purl.obolibrary.org/obo/GO_0009705 GO:0009706 biolink:CellularComponent chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. go.json chloroplast inner envelope http://purl.obolibrary.org/obo/GO_0009706 GO:0009707 biolink:CellularComponent chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. go.json chloroplast outer envelope http://purl.obolibrary.org/obo/GO_0009707 GO:0009708 biolink:BiologicalProcess benzyl isoquinoline alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. go.json benzyl isoquinoline alkaloid anabolism|benzyl isoquinoline alkaloid biosynthesis|benzyl isoquinoline alkaloid formation|benzyl isoquinoline alkaloid synthesis http://purl.obolibrary.org/obo/GO_0009708 GO:0044041 biolink:BiologicalProcess obsolete multi-organism carbohydrate catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism. go.json multi-organism carbohydrate breakdown|multi-organism carbohydrate catabolism|multi-organism carbohydrate degradation True http://purl.obolibrary.org/obo/GO_0044041 GO:0044042 biolink:BiologicalProcess glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. go.json glucan metabolism http://purl.obolibrary.org/obo/GO_0044042 GO:0044040 biolink:BiologicalProcess obsolete multi-organism carbohydrate metabolic process OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism. go.json main pathways of carbohydrate metabolic process|main pathways of carbohydrate metabolism|multi-organism carbohydrate metabolism True http://purl.obolibrary.org/obo/GO_0044040 GO:0044049 biolink:BiologicalProcess obsolete interaction with host via protein secreted by type VI secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044049 GO:0044047 biolink:BiologicalProcess obsolete interaction with host via protein secreted by type I secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044047 GO:0044048 biolink:BiologicalProcess obsolete interaction with host via protein secreted by type V secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044048 GO:0044045 biolink:BiologicalProcess obsolete interaction with host via substance in symbiont cell outer membrane OBSOLETE. An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044045 GO:0044046 biolink:BiologicalProcess obsolete interaction with host via substance released outside of symbiont OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis. go.json interaction with host via substance released outside of symbiont cells True http://purl.obolibrary.org/obo/GO_0044046 GO:0044043 biolink:BiologicalProcess obsolete multi-organism glucan metabolic process OBSOLETE. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism. go.json multi-organism glucan metabolism True http://purl.obolibrary.org/obo/GO_0044043 GO:0044044 biolink:BiologicalProcess obsolete interaction with host via substance in symbiont surface OBSOLETE. An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0044044 GO:0044052 biolink:BiologicalProcess obsolete interaction with host via substance released by membrane budding OBSOLETE. An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle. go.json interaction with host via substance released by symbiont membrane budding True http://purl.obolibrary.org/obo/GO_0044052 GO:0044053 biolink:BiologicalProcess translocation of peptides or proteins into host cell cytoplasm The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm. go.json translocation of symbiont peptides or proteins into host cell cytoplasm|transport of peptides or proteins into host cell cytoplasm http://purl.obolibrary.org/obo/GO_0044053 GO:0044050 biolink:BiologicalProcess obsolete interaction with host via substance released by sporangium lysis OBSOLETE. An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host via substance released by lysis of symbiont sporangium|interaction with host via substance released by sporangia lysis True http://purl.obolibrary.org/obo/GO_0044050 GO:0044051 biolink:BiologicalProcess obsolete interaction with host via substance released by symbiont cytolysis OBSOLETE. An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host via substance released by cytolysis of symbiont True http://purl.obolibrary.org/obo/GO_0044051 GO:0044058 biolink:BiologicalProcess regulation of digestive system process Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0044058 GO:0044059 biolink:BiologicalProcess obsolete modulation by symbiont of host endocrine process OBSOLETE. The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism. go.json regulation by symbiont of host endocrine process True http://purl.obolibrary.org/obo/GO_0044059 GO:0044056 biolink:BiologicalProcess obsolete modulation by symbiont of host digestive system process OBSOLETE. The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. go.json regulation by symbiont of host digestive system process True http://purl.obolibrary.org/obo/GO_0044056 GO:0044057 biolink:BiologicalProcess regulation of system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. go.json http://purl.obolibrary.org/obo/GO_0044057 GO:0044054 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044054 GO:0044055 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044055 GO:0044063 biolink:BiologicalProcess obsolete modulation by symbiont of host nervous system process OBSOLETE. The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. go.json modulation by symbiont of host neurological system process|regulation by symbiont of host neurological system process True http://purl.obolibrary.org/obo/GO_0044063 GO:0044064 biolink:BiologicalProcess obsolete modulation by symbiont of host respiratory system process OBSOLETE. The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. go.json regulation by symbiont of host respiratory system process True http://purl.obolibrary.org/obo/GO_0044064 GO:0044061 biolink:BiologicalProcess obsolete modulation by symbiont of host excretion OBSOLETE. The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity. go.json regulation by symbiont of host excretion True http://purl.obolibrary.org/obo/GO_0044061 GO:0044062 biolink:BiologicalProcess regulation of excretion Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. go.json http://purl.obolibrary.org/obo/GO_0044062 GO:0044060 biolink:BiologicalProcess regulation of endocrine process Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. go.json regulation of endocrine system process http://purl.obolibrary.org/obo/GO_0044060 GO:0044069 biolink:BiologicalProcess modulation by symbiont of host anion transport The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism. go.json modification of host anion transport by symbiont http://purl.obolibrary.org/obo/GO_0044069 GO:0044067 biolink:BiologicalProcess symbiont-mediated perturbation of host cell-cell junction The process in which an organism effects a change that impairs the structure or temporarily subverts the host intercellular junction. Intercellular junction include tight junctions and adherens junctions. go.json disruption of host cell-cell junction|modification by symbiont of host cell-cell junction|modification by symbiont of host intercellular junctions|modification of host cell-cell junction|modification of host intercellular junctions by symbiont|symbiont-mediated disruption of host cell-cell junction http://purl.obolibrary.org/obo/GO_0044067 GO:0044068 biolink:BiologicalProcess modulation by symbiont of host cellular process Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. go.json modulation of host cellular process by symbiont|regulation by symbiont of host cellular process|regulation of host cellular process by symbiont http://purl.obolibrary.org/obo/GO_0044068 GO:0044065 biolink:BiologicalProcess regulation of respiratory system process Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. go.json http://purl.obolibrary.org/obo/GO_0044065 GO:0044066 biolink:BiologicalProcess symbiont-mediated disruption of host cell nucleus The process in which an organism effects a change that impairs the structure or function of the host cell nucleus. go.json disruption by symbiont of host cell nucleus|modification by symbiont of host cell nucleus|modification by symbiont of host nucleus|modification of host cell nucleus by symbiont|modification of host nucleus by symbiont http://purl.obolibrary.org/obo/GO_0044066 GO:0044074 biolink:BiologicalProcess negative regulation by symbiont of host translation The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. go.json negative regulation of host translation by symbiont http://purl.obolibrary.org/obo/GO_0044074 GO:0044075 biolink:BiologicalProcess modulation by symbiont of host vacuole organization Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism. go.json modulation by symbiont of host vacuole biogenesis|modulation by symbiont of host vacuole organisation|modulation of host vacuole organization by symbiont|regulation by symbiont of host vacuole organization http://purl.obolibrary.org/obo/GO_0044075 GO:0044072 biolink:BiologicalProcess suppression of host cell cycle progression A process in which a symbiont interferes with, inhibits or stops progression through the host cell cycle. go.json cell cycle arrest in host|negative regulation by symbiont of host cell cycle http://purl.obolibrary.org/obo/GO_0044072 GO:0044073 biolink:BiologicalProcess modulation by symbiont of host translation The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. go.json modification by symbiont of host translation|modulation of host translation by symbiont|regulation by symbiont of host translation http://purl.obolibrary.org/obo/GO_0044073 GO:0044070 biolink:BiologicalProcess regulation of monoatomic anion transport Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of anion transport http://purl.obolibrary.org/obo/GO_0044070 GO:0044071 biolink:BiologicalProcess perturbation of host cell cycle progression A process in which a symbiont interferes with the normal progression through the host cell cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification by symbiont of host cell cycle|modulation by symbiont of host cell cycle|modulation of host cell cycle by symbiont|regulation by symbiont of host cell cycle http://purl.obolibrary.org/obo/GO_0044071 GO:0044078 biolink:BiologicalProcess positive regulation by symbiont of host receptor-mediated endocytosis Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism. go.json positive regulation of host receptor-mediated endocytosis by symbiont http://purl.obolibrary.org/obo/GO_0044078 GO:0044079 biolink:BiologicalProcess modulation by symbiont of host neurotransmitter secretion Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism. go.json modification by symbiont of host neurotransmitter secretion|modulation of host neurotransmitter secretion by symbiont|regulation by symbiont of host neurotransmitter secretion http://purl.obolibrary.org/obo/GO_0044079 GO:0044076 biolink:BiologicalProcess positive regulation by symbiont of host vacuole organization The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism. go.json positive regulation by symbiont of host vacuole biogenesis|positive regulation by symbiont of host vacuole organisation|positive regulation of host vacuole organization by symbiont http://purl.obolibrary.org/obo/GO_0044076 GO:0044077 biolink:BiologicalProcess modulation by symbiont of host receptor-mediated endocytosis The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism. go.json modulation of host receptor-mediated endocytosis by symbiont|regulation by symbiont of host receptor-mediated endocytosis http://purl.obolibrary.org/obo/GO_0044077 GO:0093001 biolink:BiologicalProcess glycolysis from storage polysaccharide through glucose-1-phosphate The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH. go.json http://purl.obolibrary.org/obo/GO_0093001 GO:0093002 biolink:BiologicalProcess response to nematicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes. go.json response to antihelmintic|response to nematocide http://purl.obolibrary.org/obo/GO_0093002 GO:0044085 biolink:BiologicalProcess cellular component biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. go.json cellular component biogenesis at cellular level http://purl.obolibrary.org/obo/GO_0044085 goslim_pir GO:0044086 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044086 GO:0044083 biolink:BiologicalProcess perturbation of host Rho protein signal transduction A process in which a symbiont alters a Rho protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host Rho protein mediated signal transduction|modulation by symbiont of host Rho protein signal transduction|modulation by symbiont of host Rho protein-mediated signal transduction|modulation of host Rho protein signal transduction by symbiont|modulation of host Rho protein signaling by symbiont|modulation of host Rho protein signalling by symbiont|regulation by symbiont of host Rho protein signal transduction http://purl.obolibrary.org/obo/GO_0044083 GO:0044084 biolink:CellularComponent host cell membrane pore complex Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins. go.json pore complex in host cell membrane http://purl.obolibrary.org/obo/GO_0044084 GO:0044081 biolink:BiologicalProcess obsolete symbiont-mediated suppression of host nitric oxide-mediated signaling OBSOLETE. A process in which a virus interferes with, inhibits or disrupts a nitric oxide mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host nitric oxide-mediated signaling|modulation by symbiont of host nitric oxide mediated signal transduction|modulation of host nitric oxide-mediated signal transduction by symbiont|modulation of host nitric oxide-mediated signaling by symbiont|modulation of host nitric oxide-mediated signalling by symbiont|regulation by symbiont of host nitric oxide-mediated signal transduction|suppression of host nitric oxide-mediated signaling True http://purl.obolibrary.org/obo/GO_0044081 GO:0044082 biolink:BiologicalProcess perturbation of host small GTPase mediated signal transduction A process in which a symbiont alters or subverts a small GTPase-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host small GTPase mediated signal transduction|modulation of host small GTPase mediated signal transduction by symbiont|regulation by symbiont of host small GTPase mediated signal transduction http://purl.obolibrary.org/obo/GO_0044082 GO:0044080 biolink:BiologicalProcess perturbation of host cGMP-mediated signal transduction A process in which a symbiont alters or subverts a cGMP-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host cGMP-mediated signal transduction|modulation by symbiont of host cGMP-mediated signal transduction pathway|modulation by symbiont of host cGMP-mediated signaling|modulation by symbiont of host cGMP-mediated signalling|modulation of host cGMP-mediated signal transduction by symbiont|regulation by symbiont of host cGMP-mediated signal transduction http://purl.obolibrary.org/obo/GO_0044080 GO:0044089 biolink:BiologicalProcess positive regulation of cellular component biogenesis Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. go.json http://purl.obolibrary.org/obo/GO_0044089 GO:0044087 biolink:BiologicalProcess regulation of cellular component biogenesis Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. go.json http://purl.obolibrary.org/obo/GO_0044087 GO:0044088 biolink:BiologicalProcess regulation of vacuole organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. go.json regulation of vacuole biogenesis|regulation of vacuole organisation http://purl.obolibrary.org/obo/GO_0044088 GO:0044096 biolink:CellularComponent type IV pilus A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. go.json TFP|type 4 pilus|type IV fimbriae http://purl.obolibrary.org/obo/GO_0044096 GO:0044097 biolink:BiologicalProcess secretion by the type IV secretion system The controlled release of proteins or DNA by a cell, via the type IV secretion system. go.json secretion via the type IV secretion system http://purl.obolibrary.org/obo/GO_0044097 GO:0044094 biolink:CellularComponent host cell nuclear part Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044094 gocheck_do_not_annotate GO:0044095 biolink:CellularComponent host cell nucleoplasm That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044095 GO:0044092 biolink:BiologicalProcess negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. go.json http://purl.obolibrary.org/obo/GO_0044092 gocheck_do_not_annotate GO:0044093 biolink:BiologicalProcess positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. go.json http://purl.obolibrary.org/obo/GO_0044093 gocheck_do_not_annotate GO:0044090 biolink:BiologicalProcess positive regulation of vacuole organization Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. go.json positive regulation of vacuole biogenesis|positive regulation of vacuole organisation http://purl.obolibrary.org/obo/GO_0044090 GO:0044091 biolink:BiologicalProcess membrane biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. go.json http://purl.obolibrary.org/obo/GO_0044091 GO:0044098 biolink:BiologicalProcess DNA secretion by the type IV secretion system The controlled release of DNA by a cell, via the type IV secretion system. go.json DNA secretion via the type IV secretion system http://purl.obolibrary.org/obo/GO_0044098 GO:0044099 biolink:CellularComponent polar tube A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell. go.json http://purl.obolibrary.org/obo/GO_0044099 GO:0010888 biolink:BiologicalProcess negative regulation of lipid storage Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. go.json http://purl.obolibrary.org/obo/GO_0010888 GO:0034855 biolink:MolecularActivity 4-AD 9alpha-hydroxylase activity Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O. EC:1.14.15.-|UM-BBD_reactionID:r1153 go.json http://purl.obolibrary.org/obo/GO_0034855 GO:0034856 biolink:MolecularActivity 2-hydroxyhexa-2,4-dienoate hydratase activity Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate. EC:4.2.1.132|RHEA:32535|UM-BBD_reactionID:r1281 go.json http://purl.obolibrary.org/obo/GO_0034856 GO:0010889 biolink:BiologicalProcess regulation of sequestering of triglyceride Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. go.json regulation of sequestering of triacylglycerol|regulation of triacylglycerol sequestration http://purl.obolibrary.org/obo/GO_0010889 GO:0010886 biolink:BiologicalProcess positive regulation of cholesterol storage Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json positive regulation of cholesterol sequestration http://purl.obolibrary.org/obo/GO_0010886 GO:0034857 biolink:MolecularActivity 2-(methylthio)benzothiazole monooxygenase activity Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole. UM-BBD_reactionID:r1287 go.json http://purl.obolibrary.org/obo/GO_0034857 GO:0010887 biolink:BiologicalProcess negative regulation of cholesterol storage Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json negative regulation of cholesterol sequestration http://purl.obolibrary.org/obo/GO_0010887 GO:0034858 biolink:MolecularActivity 2-hydroxybenzothiazole monooxygenase activity Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole. UM-BBD_reactionID:r1291 go.json http://purl.obolibrary.org/obo/GO_0034858 GO:0034859 biolink:MolecularActivity benzothiazole monooxygenase activity Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole. UM-BBD_reactionID:r1292 go.json http://purl.obolibrary.org/obo/GO_0034859 GO:0009891 biolink:BiologicalProcess positive regulation of biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. go.json activation of biosynthetic process|positive regulation of anabolism|positive regulation of biosynthesis|positive regulation of formation|positive regulation of synthesis|stimulation of biosynthetic process|up regulation of biosynthetic process|up-regulation of biosynthetic process|upregulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0009891 GO:0010880 biolink:BiologicalProcess regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. go.json http://purl.obolibrary.org/obo/GO_0010880 GO:0009892 biolink:BiologicalProcess negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. go.json down regulation of metabolic process|down-regulation of metabolic process|downregulation of metabolic process|inhibition of metabolic process|inhibition of organismal metabolic process|negative regulation of metabolism|negative regulation of multicellular organismal metabolic process|negative regulation of organismal metabolism http://purl.obolibrary.org/obo/GO_0009892 GO:0010881 biolink:BiologicalProcess regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. go.json http://purl.obolibrary.org/obo/GO_0010881 GO:0009893 biolink:BiologicalProcess positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. go.json activation of metabolic process|positive regulation of metabolism|positive regulation of multicellular organismal metabolic process|positive regulation of organismal metabolism|stimulation of metabolic process|stimulation of organismal metabolic process|up regulation of metabolic process|up-regulation of metabolic process|up-regulation of organismal metabolic process|upregulation of metabolic process http://purl.obolibrary.org/obo/GO_0009893 GO:0034850 biolink:MolecularActivity isooctane monooxygenase activity Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol. EC:1.13.12.-|UM-BBD_reactionID:r1269 go.json http://purl.obolibrary.org/obo/GO_0034850 GO:0009894 biolink:BiologicalProcess regulation of catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. go.json regulation of breakdown|regulation of catabolism|regulation of degradation http://purl.obolibrary.org/obo/GO_0009894 GO:0010884 biolink:BiologicalProcess positive regulation of lipid storage Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. go.json positive regulation of lipid sequestration http://purl.obolibrary.org/obo/GO_0010884 GO:0019218 biolink:BiologicalProcess regulation of steroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. go.json regulation of steroid metabolism http://purl.obolibrary.org/obo/GO_0019218 GO:0009895 biolink:BiologicalProcess negative regulation of catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. go.json down regulation of catabolic process|down-regulation of catabolic process|downregulation of catabolic process|inhibition of catabolic process|negative regulation of breakdown|negative regulation of catabolism|negative regulation of degradation http://purl.obolibrary.org/obo/GO_0009895 GO:0034851 biolink:MolecularActivity 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA. UM-BBD_reactionID:r1274 go.json http://purl.obolibrary.org/obo/GO_0034851 GO:0010885 biolink:BiologicalProcess regulation of cholesterol storage Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json http://purl.obolibrary.org/obo/GO_0010885 GO:0009896 biolink:BiologicalProcess positive regulation of catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. go.json activation of catabolic process|positive regulation of breakdown|positive regulation of catabolism|positive regulation of degradation|stimulation of catabolic process|up regulation of catabolic process|up-regulation of catabolic process|upregulation of catabolic process http://purl.obolibrary.org/obo/GO_0009896 GO:0019219 biolink:BiologicalProcess regulation of nucleobase-containing compound metabolic process Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. go.json regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism http://purl.obolibrary.org/obo/GO_0019219 GO:0034852 biolink:MolecularActivity 4,4-dimethyl-3-oxopentanal dehydrogenase activity Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-. UM-BBD_reactionID:r1309 go.json http://purl.obolibrary.org/obo/GO_0034852 GO:0010882 biolink:BiologicalProcess regulation of cardiac muscle contraction by calcium ion signaling Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. go.json regulation of cardiac muscle contraction by calcium ion signalling http://purl.obolibrary.org/obo/GO_0010882 GO:0009897 biolink:CellularComponent external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. go.json external leaflet of plasma membrane|juxtamembrane|outer surface of cytoplasmic membrane http://purl.obolibrary.org/obo/GO_0009897 GO:0034853 biolink:MolecularActivity 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2. UM-BBD_reactionID:r1278 go.json http://purl.obolibrary.org/obo/GO_0034853 GO:0019216 biolink:BiologicalProcess regulation of lipid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. go.json regulation of lipid metabolism http://purl.obolibrary.org/obo/GO_0019216 GO:0009898 biolink:CellularComponent cytoplasmic side of plasma membrane The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. go.json internal leaflet of plasma membrane|internal side of plasma membrane|juxtamembrane http://purl.obolibrary.org/obo/GO_0009898 GO:0010883 biolink:BiologicalProcess regulation of lipid storage Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. go.json regulation of lipid sequestration http://purl.obolibrary.org/obo/GO_0010883 GO:0034854 biolink:MolecularActivity 4,4-dimethyl-3-oxopentanoate decarboxylase activity Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2. UM-BBD_reactionID:r1280 go.json http://purl.obolibrary.org/obo/GO_0034854 GO:0019217 biolink:BiologicalProcess regulation of fatty acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. go.json regulation of fatty acid metabolism http://purl.obolibrary.org/obo/GO_0019217 GO:0009899 biolink:MolecularActivity ent-kaurene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate. EC:4.2.3.19|KEGG_REACTION:R05092|MetaCyc:4.2.3.19-RXN|RHEA:22220 go.json ent-copalyl-diphosphate diphosphate-lyase (cyclizing)|ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)|ent-kaurene synthase B activity|ent-kaurene synthetase B activity http://purl.obolibrary.org/obo/GO_0009899 GO:0019214 biolink:MolecularActivity obsolete surfactant activity OBSOLETE. The action of reducing the surface tension of a liquid. go.json surfactant activity True http://purl.obolibrary.org/obo/GO_0019214 GO:0019215 biolink:MolecularActivity intermediate filament binding Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. go.json http://purl.obolibrary.org/obo/GO_0019215 GO:0019212 biolink:MolecularActivity phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a phosphatase. go.json http://purl.obolibrary.org/obo/GO_0019212 GO:0019213 biolink:MolecularActivity deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. Reactome:R-HSA-5689000 go.json http://purl.obolibrary.org/obo/GO_0019213 goslim_pir GO:0019210 biolink:MolecularActivity kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a kinase. go.json http://purl.obolibrary.org/obo/GO_0019210 GO:0019211 biolink:MolecularActivity phosphatase activator activity Binds to and increases the activity of a phosphatase. go.json http://purl.obolibrary.org/obo/GO_0019211 GO:0010899 biolink:BiologicalProcess regulation of phosphatidylcholine catabolic process Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. go.json http://purl.obolibrary.org/obo/GO_0010899 GO:0034844 biolink:MolecularActivity naphthyl-2-methyl-succinate CoA-transferase activity Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate. UM-BBD_reactionID:r1256 go.json http://purl.obolibrary.org/obo/GO_0034844 GO:0034845 biolink:MolecularActivity naphthyl-2-methyl-succinyl-CoA dehydrogenase activity Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-. EC:1.3.99.-|UM-BBD_reactionID:r1258 go.json http://purl.obolibrary.org/obo/GO_0034845 GO:0010897 biolink:BiologicalProcess negative regulation of triglyceride catabolic process Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. go.json negative regulation of triacylglycerol catabolic process http://purl.obolibrary.org/obo/GO_0010897 GO:0034846 biolink:MolecularActivity naphthyl-2-methylene-succinyl-CoA lyase activity Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA. UM-BBD_reactionID:r1259 go.json http://purl.obolibrary.org/obo/GO_0034846 GO:0010898 biolink:BiologicalProcess positive regulation of triglyceride catabolic process Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. go.json positive regulation of triacylglycerol catabolic process http://purl.obolibrary.org/obo/GO_0010898 GO:0034847 biolink:MolecularActivity naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-. UM-BBD_reactionID:r1260 go.json http://purl.obolibrary.org/obo/GO_0034847 GO:0034848 biolink:MolecularActivity naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA. UM-BBD_reactionID:r1261 go.json http://purl.obolibrary.org/obo/GO_0034848 GO:0034849 biolink:MolecularActivity 2-naphthoate CoA-transferase activity Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH. UM-BBD_reactionID:r1262 go.json http://purl.obolibrary.org/obo/GO_0034849 GO:0010891 biolink:BiologicalProcess negative regulation of sequestering of triglyceride Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. go.json negative regulation of sequestering of triacylglycerol|negative regulation of triglyceride sequestration http://purl.obolibrary.org/obo/GO_0010891 GO:0010892 biolink:BiologicalProcess positive regulation of mitochondrial translation in response to stress Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress. go.json http://purl.obolibrary.org/obo/GO_0010892 GO:0010890 biolink:BiologicalProcess positive regulation of sequestering of triglyceride Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. go.json positive regulation of sequestering of triacylglycerol|positive regulation of triglyceride sequestration http://purl.obolibrary.org/obo/GO_0010890 GO:0019229 biolink:BiologicalProcess regulation of vasoconstriction Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. go.json http://purl.obolibrary.org/obo/GO_0019229 GO:0010895 biolink:BiologicalProcess negative regulation of ergosterol biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. go.json http://purl.obolibrary.org/obo/GO_0010895 GO:0034840 biolink:MolecularActivity 3-hydroxymenthone dehydrogenase activity Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+. UM-BBD_reactionID:r1185 go.json http://purl.obolibrary.org/obo/GO_0034840 GO:0034841 biolink:MolecularActivity mentha-1,3-dione-CoA ligase activity Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA. UM-BBD_reactionID:r1186 go.json http://purl.obolibrary.org/obo/GO_0034841 GO:0010896 biolink:BiologicalProcess regulation of triglyceride catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. go.json regulation of triacylglycerol catabolic process http://purl.obolibrary.org/obo/GO_0010896 GO:0034842 biolink:MolecularActivity thiophene-2-carboxylate-CoA ligase activity Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi. UM-BBD_reactionID:r1234 go.json http://purl.obolibrary.org/obo/GO_0034842 GO:0010893 biolink:BiologicalProcess positive regulation of steroid biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. go.json http://purl.obolibrary.org/obo/GO_0010893 GO:0019227 biolink:BiologicalProcess neuronal action potential propagation The propagation of an action potential along an axon, away from the soma. go.json http://purl.obolibrary.org/obo/GO_0019227 GO:0010894 biolink:BiologicalProcess negative regulation of steroid biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. go.json http://purl.obolibrary.org/obo/GO_0010894 GO:0034843 biolink:MolecularActivity 2-oxoglutaryl-CoA thioesterase activity Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH. UM-BBD_reactionID:r1238 go.json http://purl.obolibrary.org/obo/GO_0034843 GO:0019228 biolink:BiologicalProcess neuronal action potential An action potential that occurs in a neuron. go.json generation of action potential http://purl.obolibrary.org/obo/GO_0019228 GO:0019225 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019225 GO:0019226 biolink:BiologicalProcess transmission of nerve impulse The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. go.json conduction of nerve impulse|signal transmission along a neuron http://purl.obolibrary.org/obo/GO_0019226 GO:0019223 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019223 GO:0019224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019224 GO:0019221 biolink:BiologicalProcess cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json cytokine and chemokine mediated signaling pathway|cytokine mediated signalling pathway http://purl.obolibrary.org/obo/GO_0019221 GO:0019222 biolink:BiologicalProcess regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. go.json regulation of metabolism|regulation of multicellular organismal metabolic process|regulation of organismal metabolic process http://purl.obolibrary.org/obo/GO_0019222 goslim_metagenomics GO:0019220 biolink:BiologicalProcess regulation of phosphate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. go.json regulation of phosphate metabolism http://purl.obolibrary.org/obo/GO_0019220 GO:0010866 biolink:BiologicalProcess regulation of triglyceride biosynthetic process Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. go.json regulation of triacylglycerol biosynthetic process http://purl.obolibrary.org/obo/GO_0010866 GO:0044203 biolink:CellularComponent host cell nuclear lamina The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments. go.json http://purl.obolibrary.org/obo/GO_0044203 GO:0034833 biolink:MolecularActivity geranylate CoA-transferase activity Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-. UM-BBD_reactionID:r1165 go.json http://purl.obolibrary.org/obo/GO_0034833 GO:0044204 biolink:CellularComponent host cell nuclear matrix The dense fibrillar network lying on the inner side of the host nuclear membrane. go.json http://purl.obolibrary.org/obo/GO_0044204 GO:0034834 biolink:MolecularActivity 2-mercaptobenzothiazole dioxygenase activity Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol. EC:1.13.11.-|UM-BBD_reactionID:r1177 go.json http://purl.obolibrary.org/obo/GO_0034834 GO:0010867 biolink:BiologicalProcess positive regulation of triglyceride biosynthetic process Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. go.json positive regulation of triacylglycerol biosynthetic process http://purl.obolibrary.org/obo/GO_0010867 GO:0034835 biolink:MolecularActivity 2-mercaptobenzothiazole monooxygenase activity Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole. EC:1.13.12.-|UM-BBD_reactionID:r1178 go.json http://purl.obolibrary.org/obo/GO_0034835 GO:0044201 biolink:CellularComponent host cell nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope. go.json http://purl.obolibrary.org/obo/GO_0044201 GO:0010864 biolink:BiologicalProcess positive regulation of protein histidine kinase activity Any process that increases the frequency, rate or extent of protein histidine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0010864 gocheck_do_not_annotate GO:0034836 biolink:MolecularActivity 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole. EC:1.13.12.-|UM-BBD_reactionID:r1181 go.json http://purl.obolibrary.org/obo/GO_0034836 GO:0044202 biolink:CellularComponent host cell nuclear outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes. go.json http://purl.obolibrary.org/obo/GO_0044202 GO:0010865 biolink:BiologicalProcess stipule development The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms. go.json http://purl.obolibrary.org/obo/GO_0010865 GO:0034837 biolink:MolecularActivity 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-. UM-BBD_reactionID:r1179 go.json http://purl.obolibrary.org/obo/GO_0034837 GO:0034838 biolink:MolecularActivity menthone dehydrogenase activity Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+. UM-BBD_reactionID:r1183 go.json http://purl.obolibrary.org/obo/GO_0034838 GO:0044200 biolink:CellularComponent host cell nuclear membrane Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0044200 GO:0034839 biolink:MolecularActivity menth-2-enone hydratase activity Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone. UM-BBD_reactionID:r1184 go.json http://purl.obolibrary.org/obo/GO_0034839 GO:0010868 biolink:BiologicalProcess negative regulation of triglyceride biosynthetic process Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. go.json negative regulation of triacylglycerol biosynthetic process http://purl.obolibrary.org/obo/GO_0010868 GO:0010869 biolink:BiologicalProcess obsolete regulation of receptor biosynthetic process OBSOLETE. Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json True http://purl.obolibrary.org/obo/GO_0010869 GO:0009870 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009870 GO:0044209 biolink:BiologicalProcess AMP salvage The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. go.json AMP biosynthetic process via salvage pathway|adenosine monophosphate salvage http://purl.obolibrary.org/obo/GO_0044209 GO:0009871 biolink:BiologicalProcess jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance. go.json ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)|ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)|jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway|jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway|jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway|jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway|jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway http://purl.obolibrary.org/obo/GO_0009871 GO:0009872 biolink:BiologicalProcess obsolete gametophytic self-incompatibility OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place. go.json gametophytic self-incompatibility True http://purl.obolibrary.org/obo/GO_0009872 GO:0009873 biolink:BiologicalProcess ethylene-activated signaling pathway The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription. go.json ethene mediated signaling pathway|ethene mediated signalling pathway|ethylene mediated signaling pathway|ethylene mediated signalling pathway|ethylene signal transduction|ethylene signaling pathway http://purl.obolibrary.org/obo/GO_0009873 GO:0044207 biolink:CellularComponent translation initiation ternary complex A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). go.json Met-tRNA/eIF2.GTP ternary complex|translation initiation (ternary) complex http://purl.obolibrary.org/obo/GO_0044207 GO:0010862 biolink:BiologicalProcess obsolete positive regulation of pathway-restricted SMAD protein phosphorylation OBSOLETE. Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. go.json True http://purl.obolibrary.org/obo/GO_0010862 GO:0044208 biolink:BiologicalProcess 'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). go.json http://purl.obolibrary.org/obo/GO_0044208 GO:0034830 biolink:MolecularActivity (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate. EC:4.1.3.-|UM-BBD_reactionID:r1174 go.json http://purl.obolibrary.org/obo/GO_0034830 GO:0010863 biolink:BiologicalProcess positive regulation of phospholipase C activity Any process that increases the rate of phospholipase C activity. go.json http://purl.obolibrary.org/obo/GO_0010863 gocheck_do_not_annotate GO:0009874 biolink:BiologicalProcess obsolete sporophytic self-incompatibility OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place. go.json sporophytic self-incompatibility True http://purl.obolibrary.org/obo/GO_0009874 GO:0044205 biolink:BiologicalProcess 'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen. go.json 'de novo' UMP biosynthesis http://purl.obolibrary.org/obo/GO_0044205 GO:0034831 biolink:MolecularActivity (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-. UM-BBD_reactionID:r1176 go.json http://purl.obolibrary.org/obo/GO_0034831 GO:0010860 biolink:MolecularActivity obsolete proteasome regulator activity OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis. go.json proteasome regulator activity True http://purl.obolibrary.org/obo/GO_0010860 GO:0009875 biolink:BiologicalProcess pollen-pistil interaction The interaction between a pollen grain and pistil. go.json pollen-gynoecium interaction http://purl.obolibrary.org/obo/GO_0009875 GO:0044206 biolink:BiologicalProcess UMP salvage Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis. go.json UMP biosynthesis via nucleoside salvage pathway|UMP biosynthetic process via nucleoside salvage pathway http://purl.obolibrary.org/obo/GO_0044206 GO:0034832 biolink:MolecularActivity geranial dehydrogenase activity Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+. UM-BBD_reactionID:r1164 go.json http://purl.obolibrary.org/obo/GO_0034832 GO:0010861 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010861 GO:0009876 biolink:BiologicalProcess pollen adhesion The process in which pollen deposited on the stigma adheres to cells of the stigma. go.json http://purl.obolibrary.org/obo/GO_0009876 GO:0009877 biolink:BiologicalProcess nodulation The formation of nitrogen-fixing root nodules on plant roots. go.json nodule development|nodule formation|nodule morphogenesis http://purl.obolibrary.org/obo/GO_0009877 GO:0009878 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009878 GO:0009879 biolink:BiologicalProcess determination of radial symmetry The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis. go.json determination of radial asymmetry http://purl.obolibrary.org/obo/GO_0009879 GO:0034822 biolink:MolecularActivity citronellal dehydrogenase activity Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+. UM-BBD_reactionID:r1156 go.json http://purl.obolibrary.org/obo/GO_0034822 GO:0044214 biolink:CellularComponent obsolete spanning component of plasma membrane OBSOLETE. The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane. go.json fully spanning plasma membrane|transmembrane True http://purl.obolibrary.org/obo/GO_0044214 GO:0010877 biolink:BiologicalProcess lipid transport involved in lipid storage The directed movement of lipids into cells that is part of their accumulation and maintenance. go.json http://purl.obolibrary.org/obo/GO_0010877 GO:0010878 biolink:BiologicalProcess cholesterol storage The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. go.json cholesterol sequestration|sequestration of cholesterol http://purl.obolibrary.org/obo/GO_0010878 GO:0034823 biolink:MolecularActivity citronellyl-CoA ligase activity Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi. KEGG_REACTION:R08088|UM-BBD_reactionID:r1157 go.json http://purl.obolibrary.org/obo/GO_0034823 GO:0044215 biolink:CellularComponent obsolete other organism OBSOLETE. A secondary organism with which the first organism is interacting. go.json True http://purl.obolibrary.org/obo/GO_0044215 GO:0010875 biolink:BiologicalProcess positive regulation of cholesterol efflux Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0010875 GO:0034824 biolink:MolecularActivity citronellyl-CoA dehydrogenase activity Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+. UM-BBD_reactionID:r1159 go.json http://purl.obolibrary.org/obo/GO_0034824 GO:0044212 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044212 GO:0034825 biolink:MolecularActivity tetralin ring-hydroxylating dioxygenase activity Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+. EC:1.14.12.-|UM-BBD_reactionID:r1169 go.json http://purl.obolibrary.org/obo/GO_0034825 GO:0010876 biolink:BiologicalProcess lipid localization Any process in which a lipid is transported to, or maintained in, a specific location. go.json lipid localisation http://purl.obolibrary.org/obo/GO_0010876 GO:0044213 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044213 GO:0034826 biolink:MolecularActivity 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+. UM-BBD_reactionID:r1170 go.json http://purl.obolibrary.org/obo/GO_0034826 GO:0044210 biolink:BiologicalProcess 'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. go.json 'de novo' cytidine 5'-triphosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0044210 GO:0044211 biolink:BiologicalProcess CTP salvage Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis. go.json CTP biosynthetic process via salvage pathway|cytidine 5'-triphosphate salvage http://purl.obolibrary.org/obo/GO_0044211 GO:0034827 biolink:MolecularActivity 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+. EC:1.13.11.-|UM-BBD_reactionID:r1171 go.json http://purl.obolibrary.org/obo/GO_0034827 GO:0034828 biolink:MolecularActivity 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+. UM-BBD_reactionID:r1172 go.json http://purl.obolibrary.org/obo/GO_0034828 GO:0010879 biolink:BiologicalProcess cholesterol transport involved in cholesterol storage The directed movement of cholesterol into cells that is part of their accumulation and maintenance. go.json http://purl.obolibrary.org/obo/GO_0010879 GO:0009890 biolink:BiologicalProcess negative regulation of biosynthetic process Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. go.json down regulation of biosynthetic process|down-regulation of biosynthetic process|downregulation of biosynthetic process|inhibition of biosynthetic process|negative regulation of anabolism|negative regulation of biosynthesis|negative regulation of formation|negative regulation of synthesis http://purl.obolibrary.org/obo/GO_0009890 GO:0034829 biolink:MolecularActivity 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate. UM-BBD_reactionID:r1172 go.json http://purl.obolibrary.org/obo/GO_0034829 GO:0009880 biolink:BiologicalProcess embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo. go.json embryonic pattern biosynthesis|embryonic pattern formation|ventral/lateral system http://purl.obolibrary.org/obo/GO_0009880 GO:0009881 biolink:MolecularActivity photoreceptor activity The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. go.json UV-sensitive opsin|blue-sensitive opsin|green-sensitive opsin|long-wave-sensitive opsin|opsin|red-sensitive opsin|short-wave-sensitive opsin|violet-sensitive opsin http://purl.obolibrary.org/obo/GO_0009881 GO:0010870 biolink:BiologicalProcess obsolete positive regulation of receptor biosynthetic process OBSOLETE. Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json True http://purl.obolibrary.org/obo/GO_0010870 GO:0009882 biolink:MolecularActivity blue light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. go.json http://purl.obolibrary.org/obo/GO_0009882 GO:0019209 biolink:MolecularActivity kinase activator activity Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0019209 GO:0009883 biolink:MolecularActivity red or far-red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation. go.json red/far-red light photoreceptor activity http://purl.obolibrary.org/obo/GO_0009883 GO:0009884 biolink:MolecularActivity cytokinin receptor activity Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0009884 GO:0010873 biolink:BiologicalProcess obsolete positive regulation of cholesterol esterification OBSOLETE. Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. go.json True http://purl.obolibrary.org/obo/GO_0010873 GO:0019207 biolink:MolecularActivity kinase regulator activity Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0019207 GO:0044218 biolink:CellularComponent other organism cell membrane The cell membrane of a secondary organism with which the first organism is interacting. go.json foreign membrane|other organism membrane http://purl.obolibrary.org/obo/GO_0044218 GO:0044219 biolink:CellularComponent host cell plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell. go.json http://purl.obolibrary.org/obo/GO_0044219 GO:0010874 biolink:BiologicalProcess regulation of cholesterol efflux Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0010874 GO:0009885 biolink:MolecularActivity transmembrane histidine kinase cytokinin receptor activity Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. go.json http://purl.obolibrary.org/obo/GO_0009885 GO:0019208 biolink:MolecularActivity phosphatase regulator activity Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0019208 GO:0044216 biolink:CellularComponent obsolete other organism cell OBSOLETE. A cell of a secondary organism with which the first organism is interacting. go.json True http://purl.obolibrary.org/obo/GO_0044216 GO:0010871 biolink:BiologicalProcess obsolete negative regulation of receptor biosynthetic process OBSOLETE. Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json True http://purl.obolibrary.org/obo/GO_0010871 GO:0009886 biolink:BiologicalProcess post-embryonic animal morphogenesis The process, occurring after animal embryonic development, by which anatomical structures are generated and organized. go.json post-embryonic morphogenesis of an anatomical structure http://purl.obolibrary.org/obo/GO_0009886 GO:0034820 biolink:MolecularActivity 4,9-DSHA hydrolase activity Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+. UM-BBD_reactionID:r1152 go.json http://purl.obolibrary.org/obo/GO_0034820 GO:0019205 biolink:MolecularActivity nucleobase-containing compound kinase activity Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. go.json nucleobase, nucleoside, nucleotide kinase activity http://purl.obolibrary.org/obo/GO_0019205 GO:0019206 biolink:MolecularActivity nucleoside kinase activity Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. Reactome:R-HSA-109671|Reactome:R-HSA-109759|Reactome:R-HSA-109903|Reactome:R-HSA-110137|Reactome:R-HSA-110138|Reactome:R-HSA-73598|Reactome:R-HSA-73599|Reactome:R-HSA-73632 go.json http://purl.obolibrary.org/obo/GO_0019206 GO:0044217 biolink:CellularComponent other organism part Any constituent part of a secondary organism with which the first organism is interacting. go.json http://purl.obolibrary.org/obo/GO_0044217 gocheck_do_not_annotate GO:0034821 biolink:MolecularActivity citronellol dehydrogenase activity Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+. UM-BBD_reactionID:r1155 go.json http://purl.obolibrary.org/obo/GO_0034821 GO:0010872 biolink:BiologicalProcess obsolete regulation of cholesterol esterification OBSOLETE. Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. go.json True http://purl.obolibrary.org/obo/GO_0010872 GO:0009887 biolink:BiologicalProcess animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json histogenesis and organogenesis http://purl.obolibrary.org/obo/GO_0009887 GO:0009888 biolink:BiologicalProcess tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. Wikipedia:Histogenesis go.json histogenesis|histogenesis and organogenesis http://purl.obolibrary.org/obo/GO_0009888 GO:0019203 biolink:MolecularActivity carbohydrate phosphatase activity Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. Reactome:R-HSA-3781011|Reactome:R-HSA-3781018|Reactome:R-HSA-3791349 go.json http://purl.obolibrary.org/obo/GO_0019203 GO:0019204 biolink:MolecularActivity obsolete nucleotide phosphatase activity OBSOLETE. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. go.json nucleotide phosphatase activity True http://purl.obolibrary.org/obo/GO_0019204 GO:0009889 biolink:BiologicalProcess regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. go.json regulation of anabolism|regulation of biosynthesis|regulation of formation|regulation of synthesis http://purl.obolibrary.org/obo/GO_0009889 GO:0019201 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019201 GO:0019202 biolink:MolecularActivity amino acid kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. go.json http://purl.obolibrary.org/obo/GO_0019202 GO:0019200 biolink:MolecularActivity carbohydrate kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. Reactome:R-HSA-8931653 go.json http://purl.obolibrary.org/obo/GO_0019200 GO:0034819 biolink:MolecularActivity 3-HSA hydroxylase activity Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O. EC:1.14.13.-|UM-BBD_reactionID:r1150 go.json http://purl.obolibrary.org/obo/GO_0034819 GO:0044225 biolink:CellularComponent apical pole of neuron Portion of a neuron cell soma closest to the point where the apical dendrite emerges. NIF_Subcellular:sao1186862860 go.json http://purl.obolibrary.org/obo/GO_0044225 GO:0010844 biolink:MolecularActivity recombination hotspot binding Binding to a genomic region which promotes recombination. go.json DNA binding, recombination hotspot http://purl.obolibrary.org/obo/GO_0010844 GO:0034811 biolink:MolecularActivity benzo(a)pyrene 9,10-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol. EC:1.13.11.-|UM-BBD_reactionID:r1132 go.json http://purl.obolibrary.org/obo/GO_0034811 GO:0010845 biolink:BiologicalProcess positive regulation of reciprocal meiotic recombination Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json positive regulation of meiotic recombination http://purl.obolibrary.org/obo/GO_0010845 GO:0034812 biolink:MolecularActivity 9,10-dihydroxybenzo(a)pyrene dioxygenase activity Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate. EC:1.13.11.-|UM-BBD_reactionID:r1134 go.json http://purl.obolibrary.org/obo/GO_0034812 GO:0044226 biolink:CellularComponent basal pole of neuron Portion of a neuron cell soma closest to the point where the basilar dendrite emerges. NIF_Subcellular:sao1186862860 go.json http://purl.obolibrary.org/obo/GO_0044226 GO:0044223 biolink:CellularComponent pirellulosome A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm. go.json http://purl.obolibrary.org/obo/GO_0044223 GO:0034813 biolink:MolecularActivity benzo(a)pyrene 7,8-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol. EC:1.13.11.-|UM-BBD_reactionID:r1137 go.json http://purl.obolibrary.org/obo/GO_0034813 GO:0010842 biolink:BiologicalProcess retina layer formation The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. go.json retinal lamination|retinal layer formation http://purl.obolibrary.org/obo/GO_0010842 GO:0010843 biolink:MolecularActivity obsolete promoter binding OBSOLETE. Binding to a regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery. go.json DNA binding, transcription promoter|promoter binding True http://purl.obolibrary.org/obo/GO_0010843 GO:0034814 biolink:MolecularActivity 7,8-dihydroxy benzo(a)pyrene dioxygenase activity Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate. EC:1.13.11.-|UM-BBD_reactionID:r1138 go.json http://purl.obolibrary.org/obo/GO_0034814 GO:0044224 biolink:CellularComponent juxtaparanode region of axon A region of an axon near a node of Ranvier that is between the paranode and internode regions. NIF_Subcellular:sao758620702 go.json juxta paranode axon|juxtaparanodal region|juxtaparanode http://purl.obolibrary.org/obo/GO_0044224 GO:0044221 biolink:CellularComponent host cell synapse The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication. go.json http://purl.obolibrary.org/obo/GO_0044221 GO:0034815 biolink:MolecularActivity cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+. EC:4.1.3.-|UM-BBD_reactionID:r1135 go.json http://purl.obolibrary.org/obo/GO_0034815 GO:0010848 biolink:BiologicalProcess obsolete regulation of chromatin disassembly OBSOLETE. Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins. go.json True http://purl.obolibrary.org/obo/GO_0010848 GO:0034816 biolink:MolecularActivity anthracene 9,10-dioxygenase activity Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol. UM-BBD_reactionID:r1141 go.json http://purl.obolibrary.org/obo/GO_0034816 GO:0010849 biolink:BiologicalProcess regulation of proton-transporting ATPase activity, rotational mechanism Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. go.json regulation of V-type ATPase activity|regulation of hydrogen ion transporting ATPase activity, rotational mechanism http://purl.obolibrary.org/obo/GO_0010849 gocheck_do_not_annotate GO:0044222 biolink:CellularComponent anammoxosome An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism. go.json http://purl.obolibrary.org/obo/GO_0044222 GO:0034817 biolink:MolecularActivity cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-. UM-BBD_reactionID:r1144 go.json http://purl.obolibrary.org/obo/GO_0034817 GO:0010846 biolink:BiologicalProcess activation of reciprocal meiotic recombination Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. go.json activation of meiotic recombination http://purl.obolibrary.org/obo/GO_0010846 GO:0044220 biolink:CellularComponent host cell perinuclear region of cytoplasm The host cell cytoplasm situated near, or occurring around, the host nucleus. go.json http://purl.obolibrary.org/obo/GO_0044220 GO:0034818 biolink:MolecularActivity ADD 9alpha-hydroxylase activity Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin. EC:1.14.15.-|UM-BBD_reactionID:r1149 go.json http://purl.obolibrary.org/obo/GO_0034818 GO:0010847 biolink:BiologicalProcess obsolete regulation of chromatin assembly OBSOLETE. Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. go.json True http://purl.obolibrary.org/obo/GO_0010847 GO:0009850 biolink:BiologicalProcess auxin metabolic process The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth. go.json auxin metabolism http://purl.obolibrary.org/obo/GO_0009850 GO:0044229 biolink:CellularComponent host cell periplasmic space The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi). go.json http://purl.obolibrary.org/obo/GO_0044229 GO:0009851 biolink:BiologicalProcess auxin biosynthetic process The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. go.json auxin anabolism|auxin biosynthesis|auxin formation|auxin synthesis http://purl.obolibrary.org/obo/GO_0009851 GO:0010840 biolink:BiologicalProcess regulation of circadian sleep/wake cycle, wakefulness Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. go.json http://purl.obolibrary.org/obo/GO_0010840 GO:0009852 biolink:BiologicalProcess auxin catabolic process The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth. go.json auxin breakdown|auxin catabolism|auxin degradation http://purl.obolibrary.org/obo/GO_0009852 GO:0010841 biolink:BiologicalProcess positive regulation of circadian sleep/wake cycle, wakefulness Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. go.json http://purl.obolibrary.org/obo/GO_0010841 GO:0009853 biolink:BiologicalProcess photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. MetaCyc:PWY-181|Wikipedia:Photorespiration go.json photorespiratory pathway http://purl.obolibrary.org/obo/GO_0009853 GO:0044227 biolink:CellularComponent methane-oxidizing organelle A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms. go.json methane-oxidizing compartment|methanotroph intracytoplasmic membrane-bound compartment http://purl.obolibrary.org/obo/GO_0044227 GO:0034810 biolink:MolecularActivity 4,5-dihydroxybenzo(a)pyrene dioxygenase activity Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate. EC:1.13.11.-|UM-BBD_reactionID:r1128 go.json http://purl.obolibrary.org/obo/GO_0034810 GO:0009854 biolink:BiologicalProcess oxidative photosynthetic carbon pathway The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2). go.json http://purl.obolibrary.org/obo/GO_0009854 GO:0044228 biolink:CellularComponent host cell surface The external part of the host cell wall and/or host plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0044228 GO:0009855 biolink:BiologicalProcess determination of bilateral symmetry The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. go.json determination of bilateral asymmetry http://purl.obolibrary.org/obo/GO_0009855 GO:0009856 biolink:BiologicalProcess pollination The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion. Wikipedia:Pollination go.json http://purl.obolibrary.org/obo/GO_0009856 goslim_plant GO:0009857 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009857 GO:0009858 biolink:BiologicalProcess obsolete compatible pollen-pistil interaction OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style. go.json compatible pollen-pistil interaction True http://purl.obolibrary.org/obo/GO_0009858 GO:0009859 biolink:BiologicalProcess pollen hydration The process in which water is taken up by pollen. go.json http://purl.obolibrary.org/obo/GO_0009859 GO:0034808 biolink:MolecularActivity benzo(a)pyrene 4,5-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol. EC:1.13.11.-|UM-BBD_reactionID:r1126 go.json http://purl.obolibrary.org/obo/GO_0034808 GO:0034809 biolink:MolecularActivity benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2. UM-BBD_reactionID:r1127 go.json http://purl.obolibrary.org/obo/GO_0034809 GO:0010855 biolink:MolecularActivity adenylate cyclase inhibitor activity Binds to and decreases the activity of adenylate cyclase. go.json http://purl.obolibrary.org/obo/GO_0010855 GO:0034800 biolink:MolecularActivity trinitrophenol dihydride denitratase activity Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP. EC:1.7.99.-|UM-BBD_reactionID:r1067 go.json 2,4,6-trinitrophenol dihydride denitratase activity|TNP dihydride denitratase activity http://purl.obolibrary.org/obo/GO_0034800 GO:0044236 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044236 GO:0044237 biolink:BiologicalProcess cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. go.json cellular metabolism|intermediary metabolism http://purl.obolibrary.org/obo/GO_0044237 gocheck_do_not_annotate GO:0010856 biolink:MolecularActivity adenylate cyclase activator activity Binds to and increases the activity of adenylate cyclase. go.json http://purl.obolibrary.org/obo/GO_0010856 GO:0034801 biolink:MolecularActivity 2,4-dinitrocyclohexanone hydrolase activity Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate. UM-BBD_reactionID:r1069 go.json http://purl.obolibrary.org/obo/GO_0034801 GO:0010853 biolink:MolecularActivity cyclase activator activity Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction. go.json http://purl.obolibrary.org/obo/GO_0010853 GO:0034802 biolink:MolecularActivity branched-chain dodecylbenzene sulfonate monooxygenase activity Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite. EC:1.14.13.-|UM-BBD_reactionID:r1079 go.json http://purl.obolibrary.org/obo/GO_0034802 GO:0044234 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044234 GO:0010854 biolink:MolecularActivity adenylate cyclase regulator activity Binds to and modulates the activity of adenylate cyclase. go.json http://purl.obolibrary.org/obo/GO_0010854 GO:0044235 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044235 GO:0034803 biolink:MolecularActivity 3-hydroxy-2-naphthoate 2,3-dioxygenase activity Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate. EC:1.13.11.-|UM-BBD_reactionID:r1104 go.json http://purl.obolibrary.org/obo/GO_0034803 GO:0044232 biolink:CellularComponent organelle membrane contact site A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. go.json MCS|inter-organelle junction|interorganelle junction http://purl.obolibrary.org/obo/GO_0044232 GO:0010859 biolink:MolecularActivity calcium-dependent cysteine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner. go.json http://purl.obolibrary.org/obo/GO_0010859 GO:0034804 biolink:MolecularActivity benzo(a)pyrene 11,12-epoxidase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide. UM-BBD_reactionID:r1119 go.json http://purl.obolibrary.org/obo/GO_0034804 GO:0044233 biolink:CellularComponent mitochondria-associated endoplasmic reticulum membrane A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. go.json ER-mitochondrion membrane contact site|MAM|endoplasmic reticulum-mitochondrion membrane contact site|mitochondria-associated ER membrane|mitochondria-associated membrane|mitochondria-endoplasmic reticulum (ER) contact http://purl.obolibrary.org/obo/GO_0044233 GO:0034805 biolink:MolecularActivity benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-. UM-BBD_reactionID:r1121 go.json http://purl.obolibrary.org/obo/GO_0034805 GO:0034806 biolink:MolecularActivity benzo(a)pyrene 11,12-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol. EC:1.13.11.-|UM-BBD_reactionID:r1124 go.json http://purl.obolibrary.org/obo/GO_0034806 GO:0044230 biolink:CellularComponent host cell envelope An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present. go.json http://purl.obolibrary.org/obo/GO_0044230 GO:0010857 biolink:MolecularActivity calcium-dependent protein kinase activity Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. go.json http://purl.obolibrary.org/obo/GO_0010857 GO:0034807 biolink:MolecularActivity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene. UM-BBD_reactionID:r1131 go.json http://purl.obolibrary.org/obo/GO_0034807 GO:0044231 biolink:CellularComponent host cell presynaptic membrane A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. go.json host cell pre-synaptic membrane|other organism pre-synaptic membrane|other organism presynaptic membrane http://purl.obolibrary.org/obo/GO_0044231 GO:0010858 biolink:MolecularActivity calcium-dependent protein kinase regulator activity Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner. go.json http://purl.obolibrary.org/obo/GO_0010858 GO:0009860 biolink:BiologicalProcess pollen tube growth Growth of pollen via tip extension of the intine wall. go.json http://purl.obolibrary.org/obo/GO_0009860 GO:0009861 biolink:BiologicalProcess jasmonic acid and ethylene-dependent systemic resistance The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. go.json jasmonic acid and ethene-dependent systemic resistance|jasmonic acid/ethylene-dependent systemic resistance http://purl.obolibrary.org/obo/GO_0009861 GO:0009862 biolink:BiologicalProcess systemic acquired resistance, salicylic acid mediated signaling pathway The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance. go.json salicylic acid mediated signaling pathway (systemic acquired resistance)|systemic acquired resistance, salicylic acid mediated signalling pathway http://purl.obolibrary.org/obo/GO_0009862 GO:0010851 biolink:MolecularActivity cyclase regulator activity Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction. go.json http://purl.obolibrary.org/obo/GO_0010851 GO:0009863 biolink:BiologicalProcess salicylic acid mediated signaling pathway The series of molecular signals mediated by salicylic acid. go.json salicylic acid mediated signal transduction|salicylic acid mediated signalling pathway|salicylic acid-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0009863 GO:0010852 biolink:MolecularActivity cyclase inhibitor activity Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction. go.json http://purl.obolibrary.org/obo/GO_0010852 GO:0044238 biolink:BiologicalProcess primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. go.json primary metabolism http://purl.obolibrary.org/obo/GO_0044238 goslim_pir GO:0009864 biolink:BiologicalProcess induced systemic resistance, jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance. go.json induced systemic resistance, jasmonic acid mediated signalling pathway|jasmonic acid mediated signaling pathway (induced systemic resistance) http://purl.obolibrary.org/obo/GO_0009864 GO:0044239 biolink:BiologicalProcess obsolete salivary polysaccharide catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth. go.json salivary polysaccharide breakdown|salivary polysaccharide catabolism|salivary polysaccharide degradation True http://purl.obolibrary.org/obo/GO_0044239 GO:0010850 biolink:BiologicalProcess regulation of blood pressure by chemoreceptor signaling pathway A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. go.json regulation of blood pressure by chemoreceptor signalling pathway http://purl.obolibrary.org/obo/GO_0010850 GO:0009865 biolink:BiologicalProcess pollen tube adhesion The process in which the pollen tube adheres to cells of the stigma and style. go.json http://purl.obolibrary.org/obo/GO_0009865 GO:0009866 biolink:BiologicalProcess induced systemic resistance, ethylene mediated signaling pathway The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance. go.json ethene mediated signaling pathway (induced systemic resistance)|ethylene mediated signaling pathway (induced systemic resistance)|induced systemic resistance, ethene mediated signaling pathway|induced systemic resistance, ethene mediated signalling pathway|induced systemic resistance, ethylene mediated signalling pathway http://purl.obolibrary.org/obo/GO_0009866 GO:0009867 biolink:BiologicalProcess jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid. go.json JA signaling|jasmonate signaling|jasmonic acid mediated signalling pathway http://purl.obolibrary.org/obo/GO_0009867 GO:0009868 biolink:BiologicalProcess jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance. go.json jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway|jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)|jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)|jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway|jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway|jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway|jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway http://purl.obolibrary.org/obo/GO_0009868 GO:0009869 biolink:BiologicalProcess obsolete incompatible pollen-pistil interaction OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth. go.json incompatible pollen-pistil interaction True http://purl.obolibrary.org/obo/GO_0009869 GO:0044240 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044240 GO:0010828 biolink:BiologicalProcess positive regulation of glucose transmembrane transport Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json positive regulation of glucose transport http://purl.obolibrary.org/obo/GO_0010828 GO:0010829 biolink:BiologicalProcess negative regulation of glucose transmembrane transport Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json negative regulation of glucose transport http://purl.obolibrary.org/obo/GO_0010829 GO:0044247 biolink:BiologicalProcess obsolete cellular polysaccharide catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. go.json cellular polysaccharide breakdown|cellular polysaccharide catabolism|cellular polysaccharide degradation True http://purl.obolibrary.org/obo/GO_0044247 GO:0010822 biolink:BiologicalProcess positive regulation of mitochondrion organization Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. go.json positive regulation of mitochondrion organisation http://purl.obolibrary.org/obo/GO_0010822 GO:0044248 biolink:BiologicalProcess cellular catabolic process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. go.json cellular breakdown|cellular catabolism|cellular degradation http://purl.obolibrary.org/obo/GO_0044248 GO:0010823 biolink:BiologicalProcess negative regulation of mitochondrion organization Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. go.json negative regulation of mitochondrion organisation http://purl.obolibrary.org/obo/GO_0010823 GO:0010820 biolink:BiologicalProcess positive regulation of T cell chemotaxis Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0010820 GO:0044245 biolink:BiologicalProcess polysaccharide digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0044245 GO:0044246 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044246 GO:0010821 biolink:BiologicalProcess regulation of mitochondrion organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. go.json regulation of mitochondrion organisation http://purl.obolibrary.org/obo/GO_0010821 GO:0044243 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044243 GO:0010826 biolink:BiologicalProcess negative regulation of centrosome duplication Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. go.json http://purl.obolibrary.org/obo/GO_0010826 GO:0010827 biolink:BiologicalProcess regulation of glucose transmembrane transport Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of glucose transport http://purl.obolibrary.org/obo/GO_0010827 GO:0044244 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044244 GO:0044241 biolink:BiologicalProcess lipid digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0044241 GO:0010824 biolink:BiologicalProcess regulation of centrosome duplication Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. go.json http://purl.obolibrary.org/obo/GO_0010824 GO:0044242 biolink:BiologicalProcess cellular lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. go.json cellular lipid breakdown|cellular lipid catabolism|cellular lipid degradation http://purl.obolibrary.org/obo/GO_0044242 GO:0010825 biolink:BiologicalProcess positive regulation of centrosome duplication Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. go.json http://purl.obolibrary.org/obo/GO_0010825 GO:0009830 biolink:BiologicalProcess cell wall modification involved in abscission A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission. go.json cell wall modification during abscission http://purl.obolibrary.org/obo/GO_0009830 GO:0009831 biolink:BiologicalProcess plant-type cell wall modification involved in multidimensional cell growth The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana. go.json cell wall modification during cell expansion|cellulose and pectin-containing cell wall modification during multidimensional cell growth http://purl.obolibrary.org/obo/GO_0009831 GO:0044249 biolink:BiologicalProcess cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. go.json cellular anabolism|cellular biosynthesis|cellular formation|cellular synthesis http://purl.obolibrary.org/obo/GO_0044249 GO:0009832 biolink:BiologicalProcess plant-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana. go.json cell wall anabolism|cell wall assembly|cell wall biosynthetic process|cell wall formation|cell wall synthesis|cellulose and pectin-containing cell wall biogenesis http://purl.obolibrary.org/obo/GO_0009832 GO:0009833 biolink:BiologicalProcess plant-type primary cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana. go.json cellulose and pectin-containing primary cell wall biogenesis|primary cell wall anabolism|primary cell wall biogenesis|primary cell wall biosynthetic process|primary cell wall formation|primary cell wall synthesis http://purl.obolibrary.org/obo/GO_0009833 GO:0009834 biolink:BiologicalProcess plant-type secondary cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana. go.json cellulose and pectin-containing secondary cell wall biogenesis|secondary cell wall anabolism|secondary cell wall biogenesis|secondary cell wall biosynthetic process|secondary cell wall formation|secondary cell wall synthesis http://purl.obolibrary.org/obo/GO_0009834 GO:0009835 biolink:BiologicalProcess fruit ripening An developmental maturation process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal. Wikipedia:Ripening go.json fruit maturation|fruit senescence http://purl.obolibrary.org/obo/GO_0009835 goslim_plant GO:0009836 biolink:BiologicalProcess fruit ripening, climacteric A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset. go.json http://purl.obolibrary.org/obo/GO_0009836 GO:0009837 biolink:BiologicalProcess fruit ripening, non-climacteric A fruit ripening process that does not involve a respiratory burst. go.json http://purl.obolibrary.org/obo/GO_0009837 GO:0009838 biolink:BiologicalProcess abscission The controlled shedding of a body part. Wikipedia:Abscission go.json http://purl.obolibrary.org/obo/GO_0009838 goslim_plant GO:0009839 biolink:CellularComponent obsolete SCF complex substrate recognition subunit OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex. go.json SCF complex substrate recognition subunit True http://purl.obolibrary.org/obo/GO_0009839 GO:0044250 biolink:BiologicalProcess negative regulation of metabolic activity involved in hibernation The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation. go.json down regulation of metabolic activity during hibernation|down-regulation of metabolic activity during hibernation|downregulation of metabolic activity during hibernation|inhibition of metabolic activity during hibernation|negative regulation of metabolic activity during hibernation http://purl.obolibrary.org/obo/GO_0044250 GO:0044251 biolink:BiologicalProcess obsolete protein catabolic process by pepsin OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid). go.json protein breakdown by pepsin|protein degradation by pepsin True http://purl.obolibrary.org/obo/GO_0044251 GO:0010839 biolink:BiologicalProcess negative regulation of keratinocyte proliferation Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0010839 GO:0044258 biolink:BiologicalProcess intestinal lipid catabolic process The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. go.json intestinal lipid breakdown|intestinal lipid catabolism|intestinal lipid degradation http://purl.obolibrary.org/obo/GO_0044258 GO:0010833 biolink:BiologicalProcess telomere maintenance via telomere lengthening Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. go.json http://purl.obolibrary.org/obo/GO_0010833 GO:0010834 biolink:BiologicalProcess obsolete telomere maintenance via telomere shortening OBSOLETE. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA. go.json telomere maintenance via telomere shortening True http://purl.obolibrary.org/obo/GO_0010834 GO:0044259 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044259 GO:0044256 biolink:BiologicalProcess protein digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0044256 GO:0010831 biolink:BiologicalProcess positive regulation of myotube differentiation Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0010831 GO:0044257 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044257 GO:0010832 biolink:BiologicalProcess negative regulation of myotube differentiation Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0010832 GO:0044254 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044254 GO:0010837 biolink:BiologicalProcess regulation of keratinocyte proliferation Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0010837 GO:0010838 biolink:BiologicalProcess positive regulation of keratinocyte proliferation Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0010838 GO:0044255 biolink:BiologicalProcess cellular lipid metabolic process The chemical reactions and pathways involving lipids, as carried out by individual cells. go.json cellular lipid metabolism http://purl.obolibrary.org/obo/GO_0044255 goslim_pir GO:0010835 biolink:BiologicalProcess regulation of protein ADP-ribosylation Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. go.json regulation of protein amino acid ADP-ribosylation http://purl.obolibrary.org/obo/GO_0010835 gocheck_do_not_annotate GO:0044252 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044252 GO:0044253 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044253 GO:0010836 biolink:BiologicalProcess negative regulation of protein ADP-ribosylation Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. go.json negative regulation of protein amino acid ADP-ribosylation http://purl.obolibrary.org/obo/GO_0010836 gocheck_do_not_annotate GO:0009840 biolink:CellularComponent chloroplastic endopeptidase Clp complex A Clp endopeptidase complex located in the chloroplast. go.json http://purl.obolibrary.org/obo/GO_0009840 GO:0010830 biolink:BiologicalProcess regulation of myotube differentiation Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0010830 GO:0009841 biolink:CellularComponent mitochondrial endopeptidase Clp complex A Clp endopeptidase complex located in the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0009841 GO:0009842 biolink:CellularComponent cyanelle A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. go.json cyanoplast|muroplast http://purl.obolibrary.org/obo/GO_0009842 GO:0009843 biolink:CellularComponent cyanelle thylakoid A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria. go.json http://purl.obolibrary.org/obo/GO_0009843 GO:0009844 biolink:BiologicalProcess obsolete germination OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth. go.json germination True http://purl.obolibrary.org/obo/GO_0009844 GO:0009845 biolink:BiologicalProcess seed germination The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. Wikipedia:Germination#Seed_germination go.json http://purl.obolibrary.org/obo/GO_0009845 GO:0009846 biolink:BiologicalProcess pollen germination The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture. go.json http://purl.obolibrary.org/obo/GO_0009846 GO:0009847 biolink:BiologicalProcess spore germination The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall). go.json spore germination on or near host http://purl.obolibrary.org/obo/GO_0009847 GO:0009848 biolink:BiologicalProcess indoleacetic acid biosynthetic process via tryptophan The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan. MetaCyc:PWY-581 go.json IAA biosynthetic process via tryptophan|indoleacetic acid anabolism via tryptophan|indoleacetic acid formation via tryptophan|indoleacetic acid synthesis via tryptophan http://purl.obolibrary.org/obo/GO_0009848 GO:0009849 biolink:BiologicalProcess tryptophan-independent indoleacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan. MetaCyc:PWY-581 go.json indoleacetic acid biosynthesis, tryptophan-independent|indoleacetic acid biosynthetic process, tryptophan-independent|tryptophan-independent IAA biosynthetic process|tryptophan-independent indoleacetic acid anabolism|tryptophan-independent indoleacetic acid biosynthesis|tryptophan-independent indoleacetic acid formation|tryptophan-independent indoleacetic acid synthesis http://purl.obolibrary.org/obo/GO_0009849 GO:0019298 biolink:BiologicalProcess coenzyme B biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. MetaCyc:P241-PWY go.json coenzyme B anabolism|coenzyme B biosynthesis|coenzyme B formation|coenzyme B synthesis http://purl.obolibrary.org/obo/GO_0019298 GO:0019299 biolink:BiologicalProcess rhamnose metabolic process The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. go.json rhamnose metabolism http://purl.obolibrary.org/obo/GO_0019299 GO:0019296 biolink:BiologicalProcess coenzyme M metabolic process The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. go.json coenzyme M metabolism http://purl.obolibrary.org/obo/GO_0019296 GO:0019297 biolink:BiologicalProcess coenzyme B metabolic process The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. go.json coenzyme B metabolism http://purl.obolibrary.org/obo/GO_0019297 GO:0019283 biolink:BiologicalProcess L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine. go.json L-methionine anabolism from O-phospho-L-homoserine and cystathionine|L-methionine formation from O-phospho-L-homoserine and cystathionine|L-methionine synthesis from O-phospho-L-homoserine and cystathionine|methionine biosynthetic process from O-phospho-L-homoserine and cystathionine http://purl.obolibrary.org/obo/GO_0019283 GO:0019284 biolink:BiologicalProcess L-methionine salvage from S-adenosylmethionine The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine. go.json L-methionine formation from S-adenosylmethionine|L-methionine synthesis from S-adenosylmethionine http://purl.obolibrary.org/obo/GO_0019284 GO:0019281 biolink:BiologicalProcess L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine. MetaCyc:MET-SAM-PWY go.json L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine|L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine|L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine|methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine http://purl.obolibrary.org/obo/GO_0019281 GO:0019282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019282 GO:0103100 biolink:MolecularActivity UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate = H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-). EC:2.4.1.195|MetaCyc:RXNQT-4325 go.json http://purl.obolibrary.org/obo/GO_0103100 GO:0019280 biolink:BiologicalProcess L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine. MetaCyc:HSERMETANA-PWY go.json L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine|L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine|L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine|methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine http://purl.obolibrary.org/obo/GO_0019280 GO:0103101 biolink:MolecularActivity UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate = H+ + 6-methylthiohexyldesulfoglucosinolate + UDP. EC:2.4.1.195|MetaCyc:RXNQT-4326 go.json http://purl.obolibrary.org/obo/GO_0103101 GO:0103104 biolink:MolecularActivity 6-methylthiohexyldesulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate = adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate. MetaCyc:RXNQT-4331 go.json http://purl.obolibrary.org/obo/GO_0103104 GO:0103105 biolink:MolecularActivity 2-oxo-6-methylthiohexanoate aminotransferase activity Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid = dihomomethionine + a 2-oxo carboxylate. MetaCyc:RXNQT-4345 go.json http://purl.obolibrary.org/obo/GO_0103105 GO:0103102 biolink:MolecularActivity UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate = H+ + 7-methylthioheptyldesulfoglucosinolate + UDP. EC:2.4.1.195|MetaCyc:RXNQT-4327 go.json http://purl.obolibrary.org/obo/GO_0103102 GO:0103103 biolink:MolecularActivity UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate = 8-methylthiooctyldesulfoglucosinolate + UDP + H+. EC:2.4.1.195|MetaCyc:RXNQT-4328 go.json http://purl.obolibrary.org/obo/GO_0103103 GO:0103106 biolink:MolecularActivity brassinolide 23-O-glucosyltransferase activity Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose = brassinolide-23-O-glucoside + UDP + H+. MetaCyc:RXNQT-4397 go.json http://purl.obolibrary.org/obo/GO_0103106 GO:0103107 biolink:MolecularActivity castasterone 23-O-glucosyltransferase activity Catalysis of the reaction: castasterone + UDP-alpha-D-glucose = castasterone-23-O-glucoside + UDP + H+. MetaCyc:RXNQT-4398 go.json http://purl.obolibrary.org/obo/GO_0103107 GO:0019278 biolink:BiologicalProcess UDP-N-acetylgalactosamine catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. go.json UDP-N-acetylgalactosamine breakdown|UDP-N-acetylgalactosamine catabolism|UDP-N-acetylgalactosamine degradation http://purl.obolibrary.org/obo/GO_0019278 GO:0019279 biolink:BiologicalProcess L-methionine biosynthetic process from L-homoserine via cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine. MetaCyc:HOMOSER-METSYN-PWY go.json L-methionine anabolism from L-homoserine via cystathionine|L-methionine formation from L-homoserine via cystathionine|L-methionine synthesis from L-homoserine via cystathionine|methionine biosynthetic process from L-homoserine via cystathionine http://purl.obolibrary.org/obo/GO_0019279 GO:0019276 biolink:BiologicalProcess UDP-N-acetylgalactosamine metabolic process The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. go.json UDP-N-acetylgalactosamine metabolism http://purl.obolibrary.org/obo/GO_0019276 GO:0019277 biolink:BiologicalProcess UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. MetaCyc:UDPNACETYLGALSYN-PWY go.json UDP-N-acetylgalactosamine anabolism|UDP-N-acetylgalactosamine biosynthesis|UDP-N-acetylgalactosamine formation|UDP-N-acetylgalactosamine synthesis http://purl.obolibrary.org/obo/GO_0019277 GO:0019274 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019274 GO:0019275 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019275 GO:0019294 biolink:BiologicalProcess keto-3-deoxy-D-manno-octulosonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. MetaCyc:KDOSYN-PWY go.json KDO biosynthesis|KDO biosynthetic process|keto-3-deoxy-D-manno-octulosonic acid anabolism|keto-3-deoxy-D-manno-octulosonic acid biosynthesis|keto-3-deoxy-D-manno-octulosonic acid formation|keto-3-deoxy-D-manno-octulosonic acid synthesis|ketodeoxyoctanoate biosynthetic process http://purl.obolibrary.org/obo/GO_0019294 GO:0019295 biolink:BiologicalProcess coenzyme M biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. MetaCyc:P261-PWY go.json coenzyme M anabolism|coenzyme M biosynthesis|coenzyme M formation|coenzyme M synthesis http://purl.obolibrary.org/obo/GO_0019295 GO:0019292 biolink:BiologicalProcess tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate. MetaCyc:TYRSYN go.json tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate|tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate|tyrosine formation from chorismate via 4-hydroxyphenylpyruvate|tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate http://purl.obolibrary.org/obo/GO_0019292 GO:0019293 biolink:BiologicalProcess tyrosine biosynthetic process, by oxidation of phenylalanine The conversion of phenylalanine to tyrosine. MetaCyc:PWY-6134 go.json L-tyrosine biosynthesis IV|tyrosine anabolism, by oxidation of phenylalanine|tyrosine formation, by oxidation of phenylalanine|tyrosine synthesis, by oxidation of phenylalanine http://purl.obolibrary.org/obo/GO_0019293 GO:0103111 biolink:MolecularActivity D-glucosamine PTS permease activity Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine = D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine. EC:2.7.1.69|MetaCyc:TRANS-RXN-167A|RHEA:37359 go.json http://purl.obolibrary.org/obo/GO_0103111 GO:0019290 biolink:BiologicalProcess siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. go.json siderochrome biosynthesis|siderochrome biosynthetic process|siderophore anabolism|siderophore biosynthesis|siderophore biosynthetic process, peptide formation|siderophore biosynthetic process, peptide modification|siderophore formation|siderophore synthesis http://purl.obolibrary.org/obo/GO_0019290 GO:0019291 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019291 GO:0103115 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103115 GO:0103116 biolink:MolecularActivity ABC-type D-galactofuranose transporter Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O = alpha-D-galactofuranose + hydrogenphosphate + ADP + H+. EC:7.5.2.9|MetaCyc:TRANS-RXN0-491|RHEA:61716 go.json ATP-dependent alpha-D-galactofuranose transporter activity|ATPase-coupled alpha-D-galactofuranose transporter activity|alpha-D-galactofuranose transporter activity http://purl.obolibrary.org/obo/GO_0103116 GO:0103113 biolink:MolecularActivity obsolete glucosyl-oleandomycin-exporting ATPase activity OBSOLETE. Catalysis of the reaction: glucosyl-oleandomycin + ATP + H2O = glucosyl-oleandomycin + ADP + hydrogenphosphate + H+. MetaCyc:TRANS-RXN-220 go.json True http://purl.obolibrary.org/obo/GO_0103113 GO:0103117 biolink:MolecularActivity UDP-3-O-acyl-N-acetylglucosamine deacetylase activity Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate. EC:3.5.1.108|MetaCyc:UDPACYLGLCNACDEACETYL-RXN|RHEA:25209 go.json http://purl.obolibrary.org/obo/GO_0103117 GO:0103118 biolink:MolecularActivity UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] = UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]. EC:2.3.1.191|MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN|RHEA:17817 go.json UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0103118 GO:0019289 biolink:BiologicalProcess rhizobactin 1021 biosynthetic process The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. MetaCyc:PWY-761 go.json rhizobactin 1021 anabolism|rhizobactin 1021 biosynthesis|rhizobactin 1021 biosynthetic process, peptide formation|rhizobactin 1021 biosynthetic process, peptide modification|rhizobactin 1021 formation|rhizobactin 1021 synthesis http://purl.obolibrary.org/obo/GO_0019289 GO:0019287 biolink:BiologicalProcess isopentenyl diphosphate biosynthetic process, mevalonate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates. go.json Ac-MVA pathway|acetate-mevalonate pathway|isopentenyl diphosphate anabolism, mevalonate pathway|isopentenyl diphosphate biosynthetic process via mevalonate|isopentenyl diphosphate formation, mevalonate pathway|isopentenyl diphosphate synthesis, mevalonate pathway http://purl.obolibrary.org/obo/GO_0019287 GO:0019288 biolink:BiologicalProcess isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. MetaCyc:NONMEVIPP-PWY go.json isopentenyl diphosphate anabolism, mevalonate-independent pathway|isopentenyl diphosphate biosynthesis, mevalonate-independent|isopentenyl diphosphate biosynthesis, non-mevalonate pathway|isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate|isopentenyl diphosphate biosynthetic process, MEP pathway|isopentenyl diphosphate biosynthetic process, mevalonate-independent|isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|isopentenyl diphosphate biosynthetic process, non-mevalonate pathway|isopentenyl diphosphate formation, mevalonate-independent pathway|isopentenyl diphosphate synthesis, mevalonate-independent pathway|mevalonate-independent isopentenyl diphosphate biosynthesis|mevalonate-independent isopentenyl diphosphate biosynthetic process|non-MVA pathway http://purl.obolibrary.org/obo/GO_0019288 GO:0019285 biolink:BiologicalProcess glycine betaine biosynthetic process from choline The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline. MetaCyc:BETSYN-PWY|MetaCyc:CHOLINE-BETAINE-ANA-PWY|MetaCyc:P542-PWY go.json N-trimethylglycine biosynthesis from choline|N-trimethylglycine biosynthetic process from choline|choline oxidation|glycine betaine anabolism from choline|glycine betaine formation from choline|glycine betaine synthesis from choline http://purl.obolibrary.org/obo/GO_0019285 GO:0019286 biolink:BiologicalProcess glycine betaine biosynthetic process from glycine The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine. MetaCyc:P541-PWY go.json N-trimethylglycine biosynthesis from glycine|N-trimethylglycine biosynthetic process from glycine|glycine betaine anabolism from glycine|glycine betaine formation from glycine|glycine betaine synthesis from glycine http://purl.obolibrary.org/obo/GO_0019286 GO:0019261 biolink:BiologicalProcess 1,4-dichlorobenzene catabolic process The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. MetaCyc:14DICHLORBENZDEG-PWY go.json 1,4-dichlorobenzene breakdown|1,4-dichlorobenzene catabolism|1,4-dichlorobenzene degradation http://purl.obolibrary.org/obo/GO_0019261 GO:0019262 biolink:BiologicalProcess N-acetylneuraminate catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. MetaCyc:P441-PWY go.json N-acetylneuraminate breakdown|N-acetylneuraminate catabolism|N-acetylneuraminate degradation http://purl.obolibrary.org/obo/GO_0019262 GO:0019260 biolink:BiologicalProcess 1,2-dichloroethane catabolic process The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride. MetaCyc:12DICHLORETHDEG-PWY go.json 1,2-dichloroethane breakdown|1,2-dichloroethane catabolism|1,2-dichloroethane degradation http://purl.obolibrary.org/obo/GO_0019260 GO:0034899 biolink:MolecularActivity trimethylamine monooxygenase activity Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O. EC:1.14.13.148|KEGG_REACTION:R05623|RHEA:31979|UM-BBD_reactionID:r1407 go.json http://purl.obolibrary.org/obo/GO_0034899 GO:0034891 biolink:MolecularActivity endosulfan diol dehydrogenase activity Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-. UM-BBD_reactionID:r1388 go.json http://purl.obolibrary.org/obo/GO_0034891 GO:0034892 biolink:MolecularActivity endosulfan lactone lactonase activity Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+. UM-BBD_reactionID:r1389 go.json http://purl.obolibrary.org/obo/GO_0034892 GO:0034893 biolink:MolecularActivity N-nitrodimethylamine hydroxylase activity Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O. UM-BBD_reactionID:r1395 go.json http://purl.obolibrary.org/obo/GO_0034893 GO:0034894 biolink:MolecularActivity 4-hydroxypyridine-3-hydroxylase activity Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+. EC:1.14.13.-|UM-BBD_reactionID:r1397 go.json http://purl.obolibrary.org/obo/GO_0034894 GO:0034895 biolink:MolecularActivity pyridine-3,4-diol dioxygenase activity Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate. EC:1.13.11.-|UM-BBD_reactionID:r1398 go.json http://purl.obolibrary.org/obo/GO_0034895 GO:0034896 biolink:MolecularActivity 3-formiminopyruvate hydrolase activity Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3. EC:3.5.99.-|UM-BBD_reactionID:r1400 go.json http://purl.obolibrary.org/obo/GO_0034896 GO:0034897 biolink:MolecularActivity 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol. UM-BBD_reactionID:r1358 go.json http://purl.obolibrary.org/obo/GO_0034897 GO:0034898 biolink:MolecularActivity hexadecyltrimethylammonium chloride monooxygenase activity Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O. EC:1.13.12.-|UM-BBD_reactionID:r1373 go.json http://purl.obolibrary.org/obo/GO_0034898 GO:0019258 biolink:BiologicalProcess 4-nitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene. MetaCyc:P421-PWY go.json 4-nitrotoluene breakdown|4-nitrotoluene catabolism|4-nitrotoluene degradation|4NT catabolic process|4NT catabolism http://purl.obolibrary.org/obo/GO_0019258 GO:0019259 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019259 GO:0019256 biolink:BiologicalProcess acrylonitrile catabolic process The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. MetaCyc:P344-PWY go.json acrylonitrile breakdown|acrylonitrile catabolism|acrylonitrile degradation http://purl.obolibrary.org/obo/GO_0019256 GO:0019257 biolink:BiologicalProcess 4-nitrotoluene metabolic process The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor. go.json 4-nitrotoluene metabolism|4NT metabolic process|4NT metabolism http://purl.obolibrary.org/obo/GO_0019257 GO:0019254 biolink:BiologicalProcess carnitine metabolic process, CoA-linked The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA. MetaCyc:CARNMET-PWY go.json carnitine metabolism, CoA-linked http://purl.obolibrary.org/obo/GO_0019254 GO:0019255 biolink:BiologicalProcess glucose 1-phosphate metabolic process The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1. MetaCyc:GLUCOSE1PMETAB-PWY go.json glucose 1-phosphate metabolism|glucose 1-phosphate utilization http://purl.obolibrary.org/obo/GO_0019255 GO:0019252 biolink:BiologicalProcess starch biosynthetic process The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants. MetaCyc:PWY-622 go.json starch anabolism|starch biosynthesis|starch formation|starch synthesis http://purl.obolibrary.org/obo/GO_0019252 GO:0019253 biolink:BiologicalProcess reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. MetaCyc:CALVIN-PWY go.json C3 photosynthesis|Calvin cycle http://purl.obolibrary.org/obo/GO_0019253 GO:0034890 biolink:MolecularActivity endosulfan diol hydrolyase (cyclizing) activity Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O. UM-BBD_reactionID:r1386 go.json http://purl.obolibrary.org/obo/GO_0034890 GO:0019272 biolink:BiologicalProcess L-alanine biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate. MetaCyc:ALANINE-SYN2-PWY|MetaCyc:ALANINE-VALINESYN-PWY go.json L-alanine anabolism from pyruvate|L-alanine formation from pyruvate|L-alanine synthesis from pyruvate http://purl.obolibrary.org/obo/GO_0019272 GO:0019273 biolink:BiologicalProcess L-alanine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine. go.json L-alanine anabolism via ornithine|L-alanine formation via ornithine|L-alanine synthesis via ornithine http://purl.obolibrary.org/obo/GO_0019273 GO:0019270 biolink:BiologicalProcess aerobactin biosynthetic process The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. MetaCyc:AEROBACTINSYN-PWY go.json aerobactin anabolism|aerobactin biosynthesis|aerobactin formation|aerobactin synthesis http://purl.obolibrary.org/obo/GO_0019270 GO:0019271 biolink:BiologicalProcess aerobactin transport The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. go.json http://purl.obolibrary.org/obo/GO_0019271 GO:0034888 biolink:MolecularActivity endosulfan monooxygenase I activity Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O. UM-BBD_reactionID:r1382 go.json http://purl.obolibrary.org/obo/GO_0034888 GO:0034889 biolink:MolecularActivity endosulfan hemisulfate sulfatase activity Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate. UM-BBD_reactionID:r1384 go.json http://purl.obolibrary.org/obo/GO_0034889 GO:0034880 biolink:MolecularActivity citrazinate dehydrogenase activity Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-. UM-BBD_reactionID:r1339 go.json http://purl.obolibrary.org/obo/GO_0034880 GO:0034881 biolink:MolecularActivity citrazinate hydrolase activity Catalysis of the reaction: citrazinate + H2O = cis-aconitamide. UM-BBD_reactionID:r1343 go.json http://purl.obolibrary.org/obo/GO_0034881 GO:0034882 biolink:MolecularActivity cis-aconitamide amidase activity Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3. UM-BBD_reactionID:r1344 go.json http://purl.obolibrary.org/obo/GO_0034882 GO:0034883 biolink:MolecularActivity obsolete isonicotinate reductase activity OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate. go.json isonicotinate reductase activity True http://purl.obolibrary.org/obo/GO_0034883 GO:0034884 biolink:MolecularActivity obsolete gamma-N-formylaminovinylacetaldehyde dehydrogenase activity OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-. go.json gamma-N-formylaminovinylacetaldehyde dehydrogenase activity True http://purl.obolibrary.org/obo/GO_0034884 GO:0034885 biolink:MolecularActivity gamma-N-formylaminovinylacetate hydrolase activity Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH. UM-BBD_reactionID:r1350 go.json http://purl.obolibrary.org/obo/GO_0034885 GO:0034886 biolink:MolecularActivity gamma-aminovinylacetate deaminase activity Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3. EC:3.5.99.-|UM-BBD_reactionID:r1351 go.json http://purl.obolibrary.org/obo/GO_0034886 GO:0034887 biolink:MolecularActivity obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2. go.json 1,4-dihydroisonicotinate 2,3-dioxygenase activity True http://purl.obolibrary.org/obo/GO_0034887 GO:0019269 biolink:BiologicalProcess obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH). go.json glutamate anabolism, using glutamate synthase (NADPH)|glutamate biosynthetic process, using glutamate synthase (NADPH)|glutamate formation, using glutamate synthase (NADPH)|glutamate synthesis, using glutamate synthase (NADPH) True http://purl.obolibrary.org/obo/GO_0019269 GO:0019267 biolink:BiologicalProcess asparagine biosynthetic process from cysteine The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine. MetaCyc:ASPSYNII-PWY go.json asparagine anabolism from cysteine|asparagine formation from cysteine|asparagine synthesis from cysteine http://purl.obolibrary.org/obo/GO_0019267 GO:0019268 biolink:BiologicalProcess obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+). go.json glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)|glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)|glutamate formation, using glutamate dehydrogenase (NAD(P)+)|glutamate synthesis, using glutamate dehydrogenase (NAD(P)+) True http://purl.obolibrary.org/obo/GO_0019268 GO:0019265 biolink:BiologicalProcess glycine biosynthetic process, by transamination of glyoxylate The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate. go.json glycine anabolism, by transamination of glyoxylate|glycine formation, by transamination of glyoxylate|glycine synthesis, by transamination of glyoxylate http://purl.obolibrary.org/obo/GO_0019265 GO:0019266 biolink:BiologicalProcess asparagine biosynthetic process from oxaloacetate The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate. MetaCyc:ASPARAGINE-BIOSYNTHESIS go.json asparagine anabolism from oxaloacetate|asparagine formation from oxaloacetate|asparagine synthesis from oxaloacetate http://purl.obolibrary.org/obo/GO_0019266 GO:0019263 biolink:BiologicalProcess adamantanone catabolic process The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. MetaCyc:P481-PWY go.json adamantanone breakdown|adamantanone catabolism|adamantanone degradation http://purl.obolibrary.org/obo/GO_0019263 GO:0019264 biolink:BiologicalProcess glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. MetaCyc:GLYSYN-PWY go.json glycine anabolism from serine|glycine formation from serine|glycine synthesis from serine http://purl.obolibrary.org/obo/GO_0019264 GO:0019240 biolink:BiologicalProcess citrulline biosynthetic process The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. MetaCyc:CITRULBIO-PWY go.json citrulline anabolism|citrulline biosynthesis|citrulline formation|citrulline synthesis http://purl.obolibrary.org/obo/GO_0019240 GO:0034877 biolink:MolecularActivity isonicotinate dehydrogenase activity Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor. UM-BBD_reactionID:r1337 go.json http://purl.obolibrary.org/obo/GO_0034877 GO:0034878 biolink:MolecularActivity 2-hydroxyisonicotinate dehydrogenase activity Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor. UM-BBD_reactionID:r1338 go.json http://purl.obolibrary.org/obo/GO_0034878 GO:0034879 biolink:MolecularActivity 2,3,6-trihydroxyisonicotinate decarboxylase activity Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2. UM-BBD_reactionID:r1340 go.json http://purl.obolibrary.org/obo/GO_0034879 GO:0034870 biolink:MolecularActivity pinacolone 5-monooxygenase activity Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one. UM-BBD_reactionID:r12979 go.json http://purl.obolibrary.org/obo/GO_0034870 GO:0034871 biolink:MolecularActivity 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-. UM-BBD_reactionID:r1308 go.json http://purl.obolibrary.org/obo/GO_0034871 GO:0034872 biolink:MolecularActivity trans-geranyl-CoA isomerase activity Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA. EC:5.2.1.-|UM-BBD_reactionID:r1310 go.json http://purl.obolibrary.org/obo/GO_0034872 GO:0034873 biolink:MolecularActivity thioacetamide S-oxygenase activity Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O. UM-BBD_reactionID:r1312 go.json http://purl.obolibrary.org/obo/GO_0034873 GO:0034874 biolink:MolecularActivity thioacetamide S-oxide S-oxygenase activity Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O. UM-BBD_reactionID:r1313 go.json http://purl.obolibrary.org/obo/GO_0034874 GO:0019238 biolink:MolecularActivity cyclohydrolase activity Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. go.json http://purl.obolibrary.org/obo/GO_0019238 GO:0034875 biolink:MolecularActivity caffeine oxidase activity Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. EC:1.17.5.2|RHEA:47148|UM-BBD_reactionID:r1321 go.json http://purl.obolibrary.org/obo/GO_0034875 GO:0019239 biolink:MolecularActivity deaminase activity Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). Reactome:R-HSA-74241|Reactome:R-HSA-9014641|Reactome:R-HSA-9734745|Reactome:R-HSA-9754964 go.json http://purl.obolibrary.org/obo/GO_0019239 goslim_pir GO:0034876 biolink:MolecularActivity isonicotinic acid hydrazide hydrolase activity Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine. UM-BBD_reactionID:r1336 go.json http://purl.obolibrary.org/obo/GO_0034876 GO:0019236 biolink:BiologicalProcess response to pheromone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. go.json pheromone response http://purl.obolibrary.org/obo/GO_0019236 GO:0019237 biolink:MolecularActivity centromeric DNA binding Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. go.json centromere binding http://purl.obolibrary.org/obo/GO_0019237 GO:0019234 biolink:BiologicalProcess sensory perception of fast pain The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds. go.json http://purl.obolibrary.org/obo/GO_0019234 GO:0019235 biolink:BiologicalProcess sensory perception of slow pain The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction. go.json http://purl.obolibrary.org/obo/GO_0019235 GO:0019232 biolink:BiologicalProcess perception of rate of movement The series of events by which an organism senses the speed and direction of movement of the body and its parts. go.json kinesthesia http://purl.obolibrary.org/obo/GO_0019232 GO:0019233 biolink:BiologicalProcess sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. Wikipedia:Nociception go.json nociception|perception of physiological pain http://purl.obolibrary.org/obo/GO_0019233 GO:0019230 biolink:BiologicalProcess proprioception The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. Wikipedia:Proprioception go.json http://purl.obolibrary.org/obo/GO_0019230 GO:0019231 biolink:BiologicalProcess perception of static position The perception of the orientation of different parts of the body with respect to one another. go.json http://purl.obolibrary.org/obo/GO_0019231 GO:0019250 biolink:BiologicalProcess aerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen. MetaCyc:P381-PWY go.json aerobic cobalamin anabolism|aerobic cobalamin biosynthesis|aerobic cobalamin formation|aerobic cobalamin synthesis|aerobic vitamin B12 biosynthesis|aerobic vitamin B12 biosynthetic process|cobalamin biosynthesis, aerobic|cobalamin biosynthetic process, aerobic|vitamin B12 biosynthesis, aerobic|vitamin B12 biosynthetic process, aerobic http://purl.obolibrary.org/obo/GO_0019250 GO:0019251 biolink:BiologicalProcess anaerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen. MetaCyc:COBALSYN-PWY go.json anaerobic cobalamin anabolism|anaerobic cobalamin biosynthesis|anaerobic cobalamin formation|anaerobic cobalamin synthesis|anaerobic vitamin B12 biosynthesis|anaerobic vitamin B12 biosynthetic process|cobalamin biosynthesis, anaerobic|cobalamin biosynthetic process, anaerobic|vitamin B12 biosynthesis, anaerobic|vitamin B12 biosynthetic process, anaerobic http://purl.obolibrary.org/obo/GO_0019251 GO:0034866 biolink:MolecularActivity 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-. UM-BBD_reactionID:r1276 go.json http://purl.obolibrary.org/obo/GO_0034866 GO:0034867 biolink:MolecularActivity 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA. UM-BBD_reactionID:r1277 go.json http://purl.obolibrary.org/obo/GO_0034867 GO:0034868 biolink:MolecularActivity 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-. UM-BBD_reactionID:r1273 go.json http://purl.obolibrary.org/obo/GO_0034868 GO:0034869 biolink:MolecularActivity 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH. UM-BBD_reactionID:r1307 go.json http://purl.obolibrary.org/obo/GO_0034869 GO:0034860 biolink:MolecularActivity 2-mercaptobenzothiazole desulfurase activity Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor. EC:4.4.1.-|UM-BBD_reactionID:r1288 go.json http://purl.obolibrary.org/obo/GO_0034860 GO:0034861 biolink:MolecularActivity benzothiazole-2-sulfonate hydrolase activity Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-. EC:3.13.1.-|UM-BBD_reactionID:r1290 go.json http://purl.obolibrary.org/obo/GO_0034861 GO:0034862 biolink:MolecularActivity 2,6-dihydroxybenzothiazole monooxygenase activity Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole. UM-BBD_reactionID:r1294 go.json http://purl.obolibrary.org/obo/GO_0034862 GO:0034863 biolink:MolecularActivity 2,4,4-trimethyl-1-pentanol dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-. UM-BBD_reactionID:r1270 go.json http://purl.obolibrary.org/obo/GO_0034863 GO:0019249 biolink:BiologicalProcess lactate biosynthetic process The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid. go.json lactate anabolism|lactate biosynthesis|lactate formation|lactate synthesis http://purl.obolibrary.org/obo/GO_0019249 GO:0034864 biolink:MolecularActivity 2,4,4-trimethylpentanal dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-. UM-BBD_reactionID:r1275 go.json http://purl.obolibrary.org/obo/GO_0034864 GO:0034865 biolink:MolecularActivity 2,4,4-trimethylpentanoate-CoA ligase activity Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-. UM-BBD_reactionID:r1271 go.json http://purl.obolibrary.org/obo/GO_0034865 GO:0019247 biolink:BiologicalProcess lactate racemization Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture. go.json http://purl.obolibrary.org/obo/GO_0019247 GO:0019248 biolink:BiologicalProcess D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde. MetaCyc:MGLDLCTANA-PWY go.json D-lactate anabolism from methylglyoxal via (R)-lactaldehyde|D-lactate formation from methylglyoxal via (R)-lactaldehyde|D-lactate synthesis from methylglyoxal via (R)-lactaldehyde http://purl.obolibrary.org/obo/GO_0019248 GO:0019245 biolink:BiologicalProcess D(-)-lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate. go.json D(-)-lactate anabolism from pyruvate|D(-)-lactate formation from pyruvate|D(-)-lactate synthesis from pyruvate http://purl.obolibrary.org/obo/GO_0019245 GO:0019246 biolink:BiologicalProcess L(+)-lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate. MetaCyc:PWY-5481 go.json L(+)-lactate anabolism from pyruvate|L(+)-lactate formation from pyruvate|L(+)-lactate synthesis from pyruvate|S-lactate biosynthetic process from pyruvate http://purl.obolibrary.org/obo/GO_0019246 GO:0019243 biolink:BiologicalProcess methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. MetaCyc:PWY-5386 go.json D-lactate biosynthesis from methylglyoxal|D-lactate biosynthetic process from methylglyoxal|glyoxalase system|methylglyoxal breakdown to D-lactate|methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione|methylglyoxal degradation to D-lactate|methylglyoxal detoxification http://purl.obolibrary.org/obo/GO_0019243 GO:0019244 biolink:BiologicalProcess lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate. Reactome:R-HSA-71849.1 go.json lactate anabolism from pyruvate|lactate formation from pyruvate|lactate synthesis from pyruvate|pyruvate fermentation to lactate http://purl.obolibrary.org/obo/GO_0019244 GO:0019241 biolink:BiologicalProcess citrulline catabolic process The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. MetaCyc:CITRULLINE-DEG-PWY go.json citrulline breakdown|citrulline catabolism|citrulline degradation http://purl.obolibrary.org/obo/GO_0019241 GO:0019242 biolink:BiologicalProcess methylglyoxal biosynthetic process The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. go.json methylglyoxal anabolism|methylglyoxal biosynthesis|methylglyoxal formation|methylglyoxal synthesis http://purl.obolibrary.org/obo/GO_0019242 GO:0019199 biolink:MolecularActivity transmembrane receptor protein kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. Reactome:R-HSA-8983059|Reactome:R-HSA-8983063 go.json http://purl.obolibrary.org/obo/GO_0019199 GO:0019197 biolink:CellularComponent phosphoenolpyruvate-dependent sugar phosphotransferase complex Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system). go.json http://purl.obolibrary.org/obo/GO_0019197 GO:0019198 biolink:MolecularActivity transmembrane receptor protein phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. go.json http://purl.obolibrary.org/obo/GO_0019198 GO:0010808 biolink:BiologicalProcess positive regulation of synaptic vesicle priming Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. go.json http://purl.obolibrary.org/obo/GO_0010808 GO:0009819 biolink:BiologicalProcess drought recovery Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition. go.json drought tolerance http://purl.obolibrary.org/obo/GO_0009819 GO:0044140 biolink:BiologicalProcess obsolete negative regulation of growth of symbiont on or near host surface OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism. go.json True http://purl.obolibrary.org/obo/GO_0044140 GO:0044141 biolink:BiologicalProcess obsolete negative regulation of development of symbiont on or near host surface OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism. go.json True http://purl.obolibrary.org/obo/GO_0044141 GO:0010809 biolink:BiologicalProcess negative regulation of synaptic vesicle priming Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. go.json http://purl.obolibrary.org/obo/GO_0010809 GO:0010806 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010806 GO:0010807 biolink:BiologicalProcess regulation of synaptic vesicle priming Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. go.json http://purl.obolibrary.org/obo/GO_0010807 goslim_synapse GO:0044148 biolink:BiologicalProcess obsolete positive regulation of growth of symbiont involved in interaction with host OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. go.json positive regulation of growth of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0044148 GO:0010800 biolink:BiologicalProcess positive regulation of peptidyl-threonine phosphorylation Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. go.json http://purl.obolibrary.org/obo/GO_0010800 GO:0044149 biolink:BiologicalProcess positive regulation of formation of structure involved in a symbiotic process Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. go.json positive regulation of development of symbiont during interaction with host|positive regulation of development of symbiont involved in interaction with host http://purl.obolibrary.org/obo/GO_0044149 GO:0010801 biolink:BiologicalProcess negative regulation of peptidyl-threonine phosphorylation Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. go.json http://purl.obolibrary.org/obo/GO_0010801 GO:0044146 biolink:BiologicalProcess obsolete negative regulation of growth of symbiont involved in interaction with host OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. go.json negative regulation of growth of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0044146 GO:0044147 biolink:BiologicalProcess negative regulation of formation of structure involved in a symbiotic process Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. go.json negative regulation of development of symbiont during interaction with host|negative regulation of development of symbiont involved in interaction with host http://purl.obolibrary.org/obo/GO_0044147 GO:0010804 biolink:BiologicalProcess negative regulation of tumor necrosis factor-mediated signaling pathway Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. go.json negative regulation of TNF signaling|negative regulation of TNF-mediated signaling pathway|negative regulation of tumor necrosis factor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010804 GO:0044144 biolink:BiologicalProcess obsolete modulation of growth of symbiont involved in interaction with host OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. go.json modulation of growth of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0044144 GO:0044145 biolink:BiologicalProcess modulation of formation of structure involved in a symbiotic process Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. go.json modulation of development of symbiont during interaction with host|modulation of development of symbiont involved in interaction with host http://purl.obolibrary.org/obo/GO_0044145 GO:0010805 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010805 GO:0044142 biolink:BiologicalProcess obsolete positive regulation of growth of symbiont on or near host surface OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism. go.json True http://purl.obolibrary.org/obo/GO_0044142 GO:0010802 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010802 GO:0010803 biolink:BiologicalProcess regulation of tumor necrosis factor-mediated signaling pathway Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. go.json regulation of TNF signaling|regulation of TNF-mediated signaling pathway|regulation of tumor necrosis factor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010803 GO:0044143 biolink:BiologicalProcess obsolete positive regulation of development of symbiont on or near host surface OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism. go.json True http://purl.obolibrary.org/obo/GO_0044143 GO:0009810 biolink:BiologicalProcess stilbene metabolic process The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA. go.json stilbene metabolism http://purl.obolibrary.org/obo/GO_0009810 GO:0009811 biolink:BiologicalProcess stilbene biosynthetic process The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. go.json stilbene anabolism|stilbene biosynthesis|stilbene formation|stilbene synthesis http://purl.obolibrary.org/obo/GO_0009811 GO:0009812 biolink:BiologicalProcess flavonoid metabolic process The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. go.json flavonoid metabolism http://purl.obolibrary.org/obo/GO_0009812 GO:0009813 biolink:BiologicalProcess flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. MetaCyc:PWY1F-FLAVSYN|Wikipedia:Flavonoid go.json flavonoid anabolism|flavonoid biosynthesis|flavonoid formation|flavonoid synthesis http://purl.obolibrary.org/obo/GO_0009813 GO:0009814 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009814 GO:0009815 biolink:MolecularActivity 1-aminocyclopropane-1-carboxylate oxidase activity Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + dehydroascorbate + ethylene + 2 H2O + hydrogen cyanide. Ethene is also known as ethylene. EC:1.14.17.4|KEGG_REACTION:R07214|MetaCyc:ETHYL-RXN|RHEA:23640 go.json 1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)|ACC oxidase activity|aminocyclopropanecarboxylate oxidase activity|ethene-forming enzyme|ethylene-forming enzyme http://purl.obolibrary.org/obo/GO_0009815 GO:0009816 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009816 GO:0009817 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009817 GO:0009818 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009818 GO:0010819 biolink:BiologicalProcess regulation of T cell chemotaxis Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0010819 GO:0044151 biolink:BiologicalProcess obsolete growth of host on or near symbiont surface OBSOLETE. The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json growth of organism on or near symbiont surface True http://purl.obolibrary.org/obo/GO_0044151 GO:0044152 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044152 GO:0010817 biolink:BiologicalProcess regulation of hormone levels Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. go.json http://purl.obolibrary.org/obo/GO_0010817 GO:0044150 biolink:BiologicalProcess obsolete development of host on or near symbiont surface OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json development of organism on or near symbiont surface True http://purl.obolibrary.org/obo/GO_0044150 GO:0010818 biolink:BiologicalProcess T cell chemotaxis The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. go.json T-cell chemotaxis http://purl.obolibrary.org/obo/GO_0010818 GO:0044159 biolink:CellularComponent host thylakoid A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. go.json http://purl.obolibrary.org/obo/GO_0044159 GO:0010811 biolink:BiologicalProcess positive regulation of cell-substrate adhesion Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0010811 GO:0010812 biolink:BiologicalProcess negative regulation of cell-substrate adhesion Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0010812 GO:0044157 biolink:CellularComponent host cell projection A prolongation or process extending from a host cell, e.g. a flagellum or axon. go.json http://purl.obolibrary.org/obo/GO_0044157 GO:0010810 biolink:BiologicalProcess regulation of cell-substrate adhesion Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0010810 GO:0044158 biolink:CellularComponent host cell wall The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0044158 GO:0044155 biolink:CellularComponent host caveola A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0044155 GO:0010815 biolink:BiologicalProcess bradykinin catabolic process The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. go.json http://purl.obolibrary.org/obo/GO_0010815 GO:0010816 biolink:BiologicalProcess calcitonin catabolic process The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. go.json http://purl.obolibrary.org/obo/GO_0010816 GO:0044156 biolink:CellularComponent host cell junction A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0044156 GO:0010813 biolink:BiologicalProcess neuropeptide catabolic process The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction. go.json http://purl.obolibrary.org/obo/GO_0010813 GO:0044153 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044153 GO:0044154 biolink:BiologicalProcess histone H3-K14 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone. go.json histone H3 acetylation at K14|histone H3K14 acetylation http://purl.obolibrary.org/obo/GO_0044154 gocheck_do_not_annotate GO:0010814 biolink:BiologicalProcess substance P catabolic process The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P. go.json http://purl.obolibrary.org/obo/GO_0010814 GO:0009820 biolink:BiologicalProcess alkaloid metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). go.json alkaloid metabolism http://purl.obolibrary.org/obo/GO_0009820 goslim_chembl GO:0009821 biolink:BiologicalProcess alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). UM-BBD_enzymeID:e0711 go.json alkaloid anabolism|alkaloid biosynthesis|alkaloid formation|alkaloid synthesis http://purl.obolibrary.org/obo/GO_0009821 GO:0009822 biolink:BiologicalProcess alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). go.json alkaloid breakdown|alkaloid catabolism|alkaloid degradation http://purl.obolibrary.org/obo/GO_0009822 GO:0009823 biolink:BiologicalProcess cytokinin catabolic process The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators. go.json cytokinin breakdown|cytokinin catabolism|cytokinin degradation http://purl.obolibrary.org/obo/GO_0009823 GO:0009824 biolink:MolecularActivity AMP dimethylallyltransferase activity Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate. EC:2.5.1.27|KEGG_REACTION:R04038|MetaCyc:RXN-4307|RHEA:15285 go.json 2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity|2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity|adenylate dimethylallyltransferase activity|adenylate isopentenyltransferase activity|cytokinin synthase activity|dimethylallyl-diphosphate:AMP dimethylallyltransferase activity|isopentenyltransferase activity http://purl.obolibrary.org/obo/GO_0009824 GO:0009825 biolink:BiologicalProcess multidimensional cell growth The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes. go.json cell growth in three dimensions|cell growth in two dimensions http://purl.obolibrary.org/obo/GO_0009825 GO:0009826 biolink:BiologicalProcess unidimensional cell growth The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. go.json cell elongation|cell growth along one axis|cell growth in one dimension|cell morphogenesis by unidimensional growth|polar cell growth|polarized cell growth http://purl.obolibrary.org/obo/GO_0009826 GO:0009827 biolink:BiologicalProcess plant-type cell wall modification The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana. go.json cellulose and pectin-containing cell wall modification http://purl.obolibrary.org/obo/GO_0009827 GO:0009828 biolink:BiologicalProcess plant-type cell wall loosening The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana. go.json cellulose and pectin-containing cell wall loosening http://purl.obolibrary.org/obo/GO_0009828 GO:0009829 biolink:BiologicalProcess cell wall modification involved in fruit ripening The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening. go.json cell wall modification during ripening http://purl.obolibrary.org/obo/GO_0009829 GO:0044162 biolink:CellularComponent host cell cytoplasmic vesicle membrane The lipid bilayer surrounding a host cell cytoplasmic vesicle. go.json http://purl.obolibrary.org/obo/GO_0044162 GO:0044163 biolink:CellularComponent host cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic host cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. go.json http://purl.obolibrary.org/obo/GO_0044163 GO:0044160 biolink:CellularComponent host thylakoid membrane The pigmented membrane of any host thylakoid. go.json http://purl.obolibrary.org/obo/GO_0044160 GO:0044161 biolink:CellularComponent host cell cytoplasmic vesicle A vesicle formed of membrane or protein, found in the cytoplasm of a host cell. go.json http://purl.obolibrary.org/obo/GO_0044161 GO:0044168 biolink:CellularComponent host cell rough endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface. go.json host rough endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0044168 GO:0044169 biolink:CellularComponent host cell rough endoplasmic reticulum membrane The lipid bilayer surrounding the host cell rough endoplasmic reticulum. go.json host rough endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0044169 GO:0044166 biolink:CellularComponent host cell endoplasmic reticulum lumen The volume enclosed by the membranes of the host cell endoplasmic reticulum. go.json host endoplasmic reticulum lumen http://purl.obolibrary.org/obo/GO_0044166 GO:0044167 biolink:CellularComponent host cell endoplasmic reticulum membrane The lipid bilayer surrounding the host cell endoplasmic reticulum. go.json host endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0044167 GO:0044164 biolink:CellularComponent host cell cytosol The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. go.json host cytosol http://purl.obolibrary.org/obo/GO_0044164 GO:0044165 biolink:CellularComponent host cell endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). go.json host endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0044165 GO:0044173 biolink:CellularComponent host cell endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system. go.json host ER-Golgi intermediate compartment membrane|host cell ER-Golgi intermediate compartment membrane|host endoplasmic reticulum-Golgi intermediate compartment membrane http://purl.obolibrary.org/obo/GO_0044173 GO:0009808 biolink:BiologicalProcess lignin metabolic process The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units. go.json lignin metabolism http://purl.obolibrary.org/obo/GO_0009808 GO:0044174 biolink:CellularComponent host cell endosome A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation. go.json host endosome http://purl.obolibrary.org/obo/GO_0044174 GO:0009809 biolink:BiologicalProcess lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. MetaCyc:PWY-361 go.json lignin anabolism|lignin biosynthesis|lignin formation|lignin synthesis http://purl.obolibrary.org/obo/GO_0009809 GO:0044171 biolink:CellularComponent host cell smooth endoplasmic reticulum membrane The lipid bilayer surrounding the host cell smooth endoplasmic reticulum. go.json host smooth endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0044171 GO:0044172 biolink:CellularComponent host cell endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport. go.json host ER-Golgi intermediate compartment|host cell ER-Golgi intermediate compartment http://purl.obolibrary.org/obo/GO_0044172 GO:0044170 biolink:CellularComponent host cell smooth endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface. go.json host smooth endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0044170 GO:0044179 biolink:BiologicalProcess hemolysis in another organism The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another. go.json envenomation resulting in hemolysis in another organism|envenomation resulting in hemolysis in other organism|hemolysis in other organism|hemolysis of RBCs in other organism|hemolysis of cells in other organism|hemolysis of erythrocytes in other organism|hemolysis of red blood cells in other organism http://purl.obolibrary.org/obo/GO_0044179 goslim_chembl GO:0044177 biolink:CellularComponent host cell Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. go.json host Golgi apparatus http://purl.obolibrary.org/obo/GO_0044177 GO:0044178 biolink:CellularComponent host cell Golgi membrane The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus. go.json host Golgi membrane http://purl.obolibrary.org/obo/GO_0044178 GO:0044175 biolink:CellularComponent host cell endosome membrane The lipid bilayer surrounding a host cell endosome. go.json host endosome membrane http://purl.obolibrary.org/obo/GO_0044175 GO:0044176 biolink:CellularComponent host cell filopodium Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. go.json host filopodium http://purl.obolibrary.org/obo/GO_0044176 GO:0009800 biolink:BiologicalProcess cinnamic acid biosynthetic process The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid. go.json cinnamic acid anabolism|cinnamic acid biosynthesis|cinnamic acid formation|cinnamic acid synthesis|cinnamylic acid biosynthesis|cinnamylic acid biosynthetic process|phenylacrylic acid biosynthesis|phenylacrylic acid biosynthetic process|phenylpropenoic acid biosynthesis|phenylpropenoic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0009800 GO:0009801 biolink:BiologicalProcess cinnamic acid ester metabolic process The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid. go.json cinnamic acid ester metabolism http://purl.obolibrary.org/obo/GO_0009801 GO:0009802 biolink:BiologicalProcess cinnamic acid ester biosynthetic process The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid. go.json cinnamic acid ester anabolism|cinnamic acid ester biosynthesis|cinnamic acid ester formation|cinnamic acid ester synthesis|cinnamylic acid ester biosynthesis|cinnamylic acid ester biosynthetic process|phenylacrylic acid ester biosynthesis|phenylacrylic acid ester biosynthetic process http://purl.obolibrary.org/obo/GO_0009802 GO:0009803 biolink:BiologicalProcess cinnamic acid metabolic process The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid. go.json cinnamic acid metabolism|cinnamylic acid metabolic process|cinnamylic acid metabolism|phenylacrylic acid metabolic process|phenylacrylic acid metabolism|phenylpropenoic acid metabolic process|phenylpropenoic acid metabolism http://purl.obolibrary.org/obo/GO_0009803 GO:0009804 biolink:BiologicalProcess coumarin metabolic process The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. go.json coumarin metabolism http://purl.obolibrary.org/obo/GO_0009804 GO:0009805 biolink:BiologicalProcess coumarin biosynthetic process The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. MetaCyc:PWY-5176 go.json coumarin anabolism|coumarin biosynthesis|coumarin formation|coumarin synthesis http://purl.obolibrary.org/obo/GO_0009805 GO:0009806 biolink:BiologicalProcess lignan metabolic process The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. go.json lignan metabolism http://purl.obolibrary.org/obo/GO_0009806 GO:0009807 biolink:BiologicalProcess lignan biosynthetic process The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. go.json lignan anabolism|lignan biosynthesis|lignan formation|lignan synthesis http://purl.obolibrary.org/obo/GO_0009807 GO:0044184 biolink:CellularComponent host cell late endosome A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. go.json http://purl.obolibrary.org/obo/GO_0044184 GO:0044185 biolink:CellularComponent host cell late endosome membrane The lipid bilayer surrounding a host cell late endosome. go.json http://purl.obolibrary.org/obo/GO_0044185 GO:0044182 biolink:BiologicalProcess filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0044182 GO:0044183 biolink:MolecularActivity protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process. Reactome:R-HSA-9018785 go.json chaperone activity|protein binding involved in protein folding http://purl.obolibrary.org/obo/GO_0044183 goslim_chembl|goslim_drosophila|goslim_generic|prokaryote_subset GO:0044180 biolink:BiologicalProcess filamentous growth of a unicellular organism The process in which a unicellular organism grows in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0044180 GO:0044181 biolink:BiologicalProcess filamentous growth of a multicellular organism The process in which a multicellular organism grows in a threadlike, filamentous shape. go.json http://purl.obolibrary.org/obo/GO_0044181 GO:0044188 biolink:CellularComponent host cell lysosomal membrane The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0044188 GO:0044189 biolink:CellularComponent obsolete host cell microsome OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g. go.json host cell microsomal membrane|host cell microsome True http://purl.obolibrary.org/obo/GO_0044189 GO:0044186 biolink:CellularComponent host cell lipid droplet Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins. go.json host cell lipid adiposome|host cell lipid body|host cell lipid particle http://purl.obolibrary.org/obo/GO_0044186 GO:0044187 biolink:CellularComponent host cell lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions. go.json http://purl.obolibrary.org/obo/GO_0044187 GO:0044195 biolink:CellularComponent nucleoplasmic reticulum Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport. go.json nuclear channels http://purl.obolibrary.org/obo/GO_0044195 GO:0044196 biolink:CellularComponent host cell nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic host cells. go.json http://purl.obolibrary.org/obo/GO_0044196 GO:0044193 biolink:CellularComponent host cell mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope. go.json http://purl.obolibrary.org/obo/GO_0044193 GO:0044194 biolink:CellularComponent cytolytic granule A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. go.json http://purl.obolibrary.org/obo/GO_0044194 GO:0044191 biolink:CellularComponent host cell mitochondrial membrane Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope. go.json http://purl.obolibrary.org/obo/GO_0044191 GO:0044192 biolink:CellularComponent host cell mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae. go.json http://purl.obolibrary.org/obo/GO_0044192 GO:0044190 biolink:CellularComponent host cell mitochondrial envelope The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0044190 GO:0044199 biolink:CellularComponent host cell nuclear envelope The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). go.json http://purl.obolibrary.org/obo/GO_0044199 GO:0044197 biolink:MolecularActivity Rel homology domain binding Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT. go.json RHD binding http://purl.obolibrary.org/obo/GO_0044197 GO:0044198 biolink:MolecularActivity zf-TRAF domain binding Binding to a TRAF-type zinc finger domain of a protein. go.json TRAF-type zinc finger domain binding|zinc finger TRAF-type domain binding|zinc-finger-TRAF domain binding http://purl.obolibrary.org/obo/GO_0044198 GO:0044302 biolink:CellularComponent dentate gyrus mossy fiber Hippocampal mossy fiber produced by dentate gyrus granule cells. NIF_Subcellular:nlx_subcell_20090601 go.json dentate gyrus mossy fibre|granule cell axon http://purl.obolibrary.org/obo/GO_0044302 GO:0034976 biolink:BiologicalProcess response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. go.json ER stress response|cellular response to endoplasmic reticulum stress|response to ER stress http://purl.obolibrary.org/obo/GO_0034976 GO:0044303 biolink:CellularComponent axon collateral Any of the smaller branches of an axon that emanate from the main axon cylinder. NIF_Subcellular:sao1470140754 go.json http://purl.obolibrary.org/obo/GO_0044303 GO:0034977 biolink:CellularComponent ABIN2-NFKB1-MAP3K8 complex A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages. go.json ABIN2-NFKB1-TPL-1 complex http://purl.obolibrary.org/obo/GO_0034977 GO:0044300 biolink:CellularComponent cerebellar mossy fiber An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations. NIF_Subcellular:nlx_subcell_20090209 go.json cerebellar mossy fibre http://purl.obolibrary.org/obo/GO_0044300 GO:0034978 biolink:CellularComponent PDX1-PBX1b-MRG1 complex A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes. go.json acinar cell-specific C complex http://purl.obolibrary.org/obo/GO_0034978 GO:0034979 biolink:MolecularActivity NAD-dependent protein deacetylase activity Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. Reactome:R-HSA-3371467|Reactome:R-HSA-5211239|Reactome:R-HSA-5685953|Reactome:R-HSA-5688289|Reactome:R-HSA-5688294|Reactome:R-HSA-9620532|Reactome:R-HSA-9667952 go.json http://purl.obolibrary.org/obo/GO_0034979 GO:0044301 biolink:CellularComponent climbing fiber The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber. NIF_Subcellular:nlx_subcell_20090203 go.json climbing fibre http://purl.obolibrary.org/obo/GO_0044301 GO:0034970 biolink:BiologicalProcess histone H3-R2 methylation The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone. go.json histone H3 R2 methylation|histone H3R2me|histone lysine H3 R2 methylation http://purl.obolibrary.org/obo/GO_0034970 gocheck_do_not_annotate GO:0044308 biolink:CellularComponent axonal spine A spine that originates from the axon, usually from the initial segment. NIF_Subcellular:sao18239917 go.json axon spine http://purl.obolibrary.org/obo/GO_0044308 GO:0044309 biolink:CellularComponent neuron spine A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. NIF_Subcellular:sao1145756102 go.json spine http://purl.obolibrary.org/obo/GO_0044309 GO:0034971 biolink:BiologicalProcess histone H3-R17 methylation The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone. go.json histone H3 R17 methylation|histone H3R17me|histone lysine H3 R17 methylation http://purl.obolibrary.org/obo/GO_0034971 gocheck_do_not_annotate GO:0034972 biolink:BiologicalProcess histone H3-R26 methylation The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone. go.json histone H3 R26 methylation|histone H3R26me|histone lysine H3 R26 methylation http://purl.obolibrary.org/obo/GO_0034972 gocheck_do_not_annotate GO:0019339 biolink:BiologicalProcess parathion catabolic process The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition. MetaCyc:PARATHION-DEGRADATION-PWY go.json parathion breakdown|parathion catabolism|parathion degradation http://purl.obolibrary.org/obo/GO_0019339 GO:0044306 biolink:CellularComponent neuron projection terminus The specialized, terminal region of a neuron projection such as an axon or a dendrite. go.json nerve terminal|neuron projection terminal|neuron terminal specialization http://purl.obolibrary.org/obo/GO_0044306 GO:0044307 biolink:CellularComponent dendritic branch A dendrite arising from another dendrite. NIF_Subcellular:sao884265541 go.json dendrite branch|secondary dendrite http://purl.obolibrary.org/obo/GO_0044307 GO:0034973 biolink:CellularComponent Sid2-Mob1 complex A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex. go.json Dbf2p-Mob1p complex|Sid2-Mob1 kinase complex|Sid2p-Mob1p complex http://purl.obolibrary.org/obo/GO_0034973 GO:0044304 biolink:CellularComponent main axon The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. NIF_Subcellular:sao1596975044 go.json axon shaft|axon trunk|axonal shaft http://purl.obolibrary.org/obo/GO_0044304 GO:0019337 biolink:BiologicalProcess tetrachloroethylene catabolic process The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines. MetaCyc:PCEDEG-PWY go.json tetrachloroethene catabolic process|tetrachloroethene catabolism|tetrachloroethylene breakdown|tetrachloroethylene catabolism|tetrachloroethylene degradation http://purl.obolibrary.org/obo/GO_0019337 GO:0034974 biolink:CellularComponent Swi5-Swi2 complex A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching. go.json Swi5 complex http://purl.obolibrary.org/obo/GO_0034974 GO:0019338 biolink:BiologicalProcess pentachlorophenol catabolic process The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. MetaCyc:PCPDEG-PWY go.json pentachlorophenol breakdown|pentachlorophenol catabolism|pentachlorophenol degradation http://purl.obolibrary.org/obo/GO_0019338 GO:0034975 biolink:BiologicalProcess protein folding in endoplasmic reticulum A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). go.json oxidative protein folding|protein folding in ER http://purl.obolibrary.org/obo/GO_0034975 GO:0044305 biolink:CellularComponent calyx of Held The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. NIF_Subcellular:sao1684283879 go.json http://purl.obolibrary.org/obo/GO_0044305 GO:0019335 biolink:BiologicalProcess 3-methylquinoline catabolic process The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. MetaCyc:PWY-721 go.json 3-methylquinoline breakdown|3-methylquinoline catabolism|3-methylquinoline degradation http://purl.obolibrary.org/obo/GO_0019335 GO:0019336 biolink:BiologicalProcess phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. MetaCyc:PHENOLDEG-PWY go.json phenol-containing compound breakdown|phenol-containing compound catabolism|phenol-containing compound degradation http://purl.obolibrary.org/obo/GO_0019336 GO:0019333 biolink:BiologicalProcess denitrification pathway The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen. MetaCyc:DENITRIFICATION-PWY go.json http://purl.obolibrary.org/obo/GO_0019333 GO:0019334 biolink:BiologicalProcess p-cymene catabolic process The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants. MetaCyc:PWY-741 go.json p-cymene breakdown|p-cymene catabolism|p-cymene degradation http://purl.obolibrary.org/obo/GO_0019334 GO:0019331 biolink:BiologicalProcess anaerobic respiration, using ammonium as electron donor The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2. MetaCyc:P303-PWY|Wikipedia:Anammox go.json anaerobic ammonium oxidation|anammox http://purl.obolibrary.org/obo/GO_0019331 GO:0019332 biolink:BiologicalProcess aerobic respiration, using nitrite as electron donor The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species. MetaCyc:P282-PWY go.json nitrite oxidation http://purl.obolibrary.org/obo/GO_0019332 GO:0019330 biolink:BiologicalProcess aldoxime metabolic process The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH. MetaCyc:P345-PWY go.json aldoxime metabolism http://purl.obolibrary.org/obo/GO_0019330 GO:0019350 biolink:BiologicalProcess teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. MetaCyc:TEICHOICACID-PWY go.json teichoic acid anabolism|teichoic acid biosynthesis|teichoic acid formation|teichoic acid synthesis http://purl.obolibrary.org/obo/GO_0019350 GO:0044313 biolink:BiologicalProcess protein K6-linked deubiquitination A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein. go.json http://purl.obolibrary.org/obo/GO_0044313 gocheck_do_not_annotate GO:0034965 biolink:BiologicalProcess intronic box C/D RNA processing Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA. go.json intronic box C/D sRNA processing|intronic box C/D snoRNA processing http://purl.obolibrary.org/obo/GO_0034965 GO:0044314 biolink:BiologicalProcess protein K27-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein. go.json protein K27-linked polyubiquitination http://purl.obolibrary.org/obo/GO_0044314 GO:0034966 biolink:BiologicalProcess intronic box H/ACA snoRNA processing Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA. go.json http://purl.obolibrary.org/obo/GO_0034966 GO:0034967 biolink:CellularComponent Set3 complex A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p. go.json HDAC3 complex|SET3C http://purl.obolibrary.org/obo/GO_0034967 GO:0044311 biolink:CellularComponent exoneme A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte. go.json http://purl.obolibrary.org/obo/GO_0044311 GO:0044312 biolink:CellularComponent crystalloid A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation. go.json http://purl.obolibrary.org/obo/GO_0044312 GO:0034968 biolink:BiologicalProcess histone lysine methylation The modification of a histone by addition of one or more methyl groups to a lysine residue. go.json http://purl.obolibrary.org/obo/GO_0034968 gocheck_do_not_annotate GO:0034969 biolink:BiologicalProcess histone arginine methylation The modification of a histone by addition of a methyl group to an arginine residue. go.json http://purl.obolibrary.org/obo/GO_0034969 gocheck_do_not_annotate GO:0044310 biolink:CellularComponent osmiophilic body A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito. go.json http://purl.obolibrary.org/obo/GO_0044310 GO:0044319 biolink:BiologicalProcess wound healing, spreading of cells The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface. go.json cell migration involved in wound healing epiboly http://purl.obolibrary.org/obo/GO_0044319 GO:0034960 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034960 GO:0044317 biolink:CellularComponent rod spherule A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body. go.json rod cell spherule|rod photoreceptor spherule http://purl.obolibrary.org/obo/GO_0044317 GO:0034961 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034961 GO:0044318 biolink:MolecularActivity L-aspartate:fumarate oxidoreductase activity Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate. EC:1.4.3.16 go.json http://purl.obolibrary.org/obo/GO_0044318 GO:0034962 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034962 GO:0019348 biolink:BiologicalProcess dolichol metabolic process The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. go.json dolichol metabolism http://purl.obolibrary.org/obo/GO_0019348 GO:0044315 biolink:BiologicalProcess protein secretion by the type VII secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system. go.json http://purl.obolibrary.org/obo/GO_0044315 GO:0034963 biolink:BiologicalProcess box C/D RNA processing Any process involved in the conversion of a primary box C/D type small RNA transcript into a mature box C/D RNA. go.json box C/D sRNA processing|box C/D snoRNA processing http://purl.obolibrary.org/obo/GO_0034963 GO:0044316 biolink:CellularComponent cone cell pedicle A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL). go.json cone pedicle http://purl.obolibrary.org/obo/GO_0044316 GO:0034964 biolink:BiologicalProcess box H/ACA RNA processing Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA. go.json box H/ACA sRNA processing|box H/ACA snoRNA processing http://purl.obolibrary.org/obo/GO_0034964 GO:0019349 biolink:BiologicalProcess ribitol metabolic process The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin. go.json ribitol metabolism http://purl.obolibrary.org/obo/GO_0019349 GO:0019346 biolink:BiologicalProcess transsulfuration The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. MetaCyc:PWY-801|Wikipedia:Transsulfuration_pathway go.json homocysteine-cysteine interconversion|transsulphuration http://purl.obolibrary.org/obo/GO_0019346 GO:0019347 biolink:BiologicalProcess GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate. MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS go.json GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism|GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis|GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation|GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis http://purl.obolibrary.org/obo/GO_0019347 GO:0019344 biolink:BiologicalProcess cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. go.json cysteine anabolism|cysteine biosynthesis|cysteine formation|cysteine synthesis http://purl.obolibrary.org/obo/GO_0019344 GO:0019345 biolink:BiologicalProcess cysteine biosynthetic process via S-sulfo-L-cysteine The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine. go.json cysteine anabolism via S-sulfo-L-cysteine|cysteine biosynthesis via S-sulpho-L-cysteine|cysteine biosynthetic process via S-sulpho-L-cysteine|cysteine formation via S-sulfo-L-cysteine|cysteine synthesis via S-sulfo-L-cysteine http://purl.obolibrary.org/obo/GO_0019345 GO:0019342 biolink:BiologicalProcess trypanothione biosynthetic process The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress. MetaCyc:TRYPANOSYN-PWY go.json trypanothione anabolism|trypanothione biosynthesis|trypanothione formation|trypanothione synthesis http://purl.obolibrary.org/obo/GO_0019342 GO:0019343 biolink:BiologicalProcess cysteine biosynthetic process via cystathionine The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. go.json cysteine anabolism via cystathionine|cysteine formation via cystathionine|cysteine synthesis via cystathionine http://purl.obolibrary.org/obo/GO_0019343 GO:0019340 biolink:BiologicalProcess dibenzofuran catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. MetaCyc:P662-PWY go.json dibenzofuran breakdown|dibenzofuran catabolism|dibenzofuran degradation http://purl.obolibrary.org/obo/GO_0019340 GO:0019341 biolink:BiologicalProcess dibenzo-p-dioxin catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. MetaCyc:P661-PWY go.json dibenzo-p-dioxin breakdown|dibenzo-p-dioxin catabolism|dibenzo-p-dioxin degradation http://purl.obolibrary.org/obo/GO_0019341 GO:0034954 biolink:MolecularActivity diphenyl ether 2,3-dioxygenase activity Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether. EC:1.14.12.-|UM-BBD_reactionID:r1450 go.json http://purl.obolibrary.org/obo/GO_0034954 GO:0010987 biolink:BiologicalProcess negative regulation of high-density lipoprotein particle clearance Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010987 GO:0044324 biolink:BiologicalProcess obsolete regulation of transcription involved in anterior/posterior axis specification OBSOLETE. Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis. go.json True http://purl.obolibrary.org/obo/GO_0044324 GO:0034955 biolink:MolecularActivity 2,3-dihydroxydiphenyl ether dioxygenase activity Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol. EC:1.13.11.-|UM-BBD_reactionID:r1451 go.json http://purl.obolibrary.org/obo/GO_0034955 GO:0010988 biolink:BiologicalProcess regulation of low-density lipoprotein particle clearance Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010988 GO:0044325 biolink:MolecularActivity transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. go.json ion channel binding http://purl.obolibrary.org/obo/GO_0044325 goslim_chembl GO:0044322 biolink:CellularComponent endoplasmic reticulum quality control compartment A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. go.json ER quality control compartment|ER-derived quality control compartment|ERQC http://purl.obolibrary.org/obo/GO_0044322 GO:0034956 biolink:MolecularActivity diphenyl ether 1,2-dioxygenase activity Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+. EC:1.13.11.-|UM-BBD_reactionID:r1453 go.json http://purl.obolibrary.org/obo/GO_0034956 GO:0010985 biolink:BiologicalProcess negative regulation of lipoprotein particle clearance Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010985 GO:0044323 biolink:MolecularActivity retinoic acid-responsive element binding Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. go.json RARE binding http://purl.obolibrary.org/obo/GO_0044323 GO:0034957 biolink:MolecularActivity 3-nitrophenol nitroreductase activity Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O. UM-BBD_reactionID:r1495 go.json http://purl.obolibrary.org/obo/GO_0034957 GO:0010986 biolink:BiologicalProcess positive regulation of lipoprotein particle clearance Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010986 GO:0044320 biolink:BiologicalProcess cellular response to leptin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. go.json http://purl.obolibrary.org/obo/GO_0044320 GO:0034958 biolink:MolecularActivity aminohydroquinone monooxygenase activity Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3. EC:3.5.99.-|UM-BBD_reactionID:r1497 go.json http://purl.obolibrary.org/obo/GO_0034958 GO:0044321 biolink:BiologicalProcess response to leptin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. go.json response to leptin stimulus http://purl.obolibrary.org/obo/GO_0044321 GO:0034959 biolink:BiologicalProcess endothelin maturation The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin. go.json http://purl.obolibrary.org/obo/GO_0034959 GO:0010989 biolink:BiologicalProcess negative regulation of low-density lipoprotein particle clearance Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010989 GO:0009990 biolink:BiologicalProcess contact guidance Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells. go.json http://purl.obolibrary.org/obo/GO_0009990 GO:0010980 biolink:BiologicalProcess positive regulation of vitamin D 24-hydroxylase activity Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D. go.json http://purl.obolibrary.org/obo/GO_0010980 gocheck_do_not_annotate GO:0009991 biolink:BiologicalProcess response to extracellular stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. go.json http://purl.obolibrary.org/obo/GO_0009991 GO:0019319 biolink:BiologicalProcess hexose biosynthetic process The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. go.json hexose anabolism|hexose biosynthesis|hexose formation|hexose synthesis http://purl.obolibrary.org/obo/GO_0019319 GO:0009992 biolink:BiologicalProcess intracellular water homeostasis A homeostatic process involved in the maintenance of a steady state level of water within a cell. go.json cellular osmoregulation|cellular water homeostasis http://purl.obolibrary.org/obo/GO_0009992 GO:0009993 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009993 GO:0009994 biolink:BiologicalProcess oocyte differentiation The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. go.json oocyte cell differentiation http://purl.obolibrary.org/obo/GO_0009994 GO:0034950 biolink:MolecularActivity phenylboronic acid monooxygenase activity Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3. UM-BBD_reactionID:r1020 go.json http://purl.obolibrary.org/obo/GO_0034950 GO:0019317 biolink:BiologicalProcess fucose catabolic process The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose). MetaCyc:FUCCAT-PWY go.json fucose breakdown|fucose catabolism|fucose degradation http://purl.obolibrary.org/obo/GO_0019317 GO:0044328 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration. go.json canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration http://purl.obolibrary.org/obo/GO_0044328 GO:0010983 biolink:BiologicalProcess positive regulation of high-density lipoprotein particle clearance Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010983 GO:0019318 biolink:BiologicalProcess hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. go.json hexose metabolism http://purl.obolibrary.org/obo/GO_0019318 GO:0044329 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion. go.json canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt-activated signaling pathway involved in positive regulation of cell-cell adhesion http://purl.obolibrary.org/obo/GO_0044329 GO:0010984 biolink:BiologicalProcess regulation of lipoprotein particle clearance Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010984 GO:0034951 biolink:MolecularActivity o-hydroxylaminobenzoate mutase activity Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate. EC:5.4.99.-|MetaCyc:RXN-8846|UM-BBD_reactionID:r1026 go.json http://purl.obolibrary.org/obo/GO_0034951 GO:0009995 biolink:BiologicalProcess soluble molecule recognition The recognition of soluble molecules in the environment. go.json http://purl.obolibrary.org/obo/GO_0009995 GO:0019315 biolink:BiologicalProcess D-allose biosynthetic process The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose. go.json D-allose anabolism|D-allose biosynthesis|D-allose formation|D-allose synthesis http://purl.obolibrary.org/obo/GO_0019315 GO:0044326 biolink:CellularComponent dendritic spine neck Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine. NIF_Subcellular:sao1642908940 go.json neck|pedicle|spine neck http://purl.obolibrary.org/obo/GO_0044326 GO:0034952 biolink:MolecularActivity malonate semialdehyde decarboxylase activity Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2. UM-BBD_reactionID:r0266 go.json http://purl.obolibrary.org/obo/GO_0034952 GO:0009996 biolink:BiologicalProcess negative regulation of cell fate specification Any process that restricts, stops or prevents a cell from adopting a specific cell fate. go.json down regulation of cell fate specification|down-regulation of cell fate specification|downregulation of cell fate specification|inhibition of cell fate specification|suppression of cell fate http://purl.obolibrary.org/obo/GO_0009996 GO:0010981 biolink:BiologicalProcess regulation of cell wall macromolecule metabolic process Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. go.json http://purl.obolibrary.org/obo/GO_0010981 GO:0034953 biolink:MolecularActivity perillyl-CoA hydratase activity Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA. UM-BBD_reactionID:r1002 go.json http://purl.obolibrary.org/obo/GO_0034953 GO:0019316 biolink:BiologicalProcess D-allose catabolic process The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose. MetaCyc:PWY0-44 go.json D-allose breakdown|D-allose catabolism|D-allose degradation http://purl.obolibrary.org/obo/GO_0019316 GO:0009997 biolink:BiologicalProcess negative regulation of cardioblast cell fate specification Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json down regulation of cardioblast cell fate specification|down-regulation of cardioblast cell fate specification|downregulation of cardioblast cell fate specification|inhibition of cardioblast cell fate specification|suppression of cardioblast cell fate http://purl.obolibrary.org/obo/GO_0009997 GO:0044327 biolink:CellularComponent dendritic spine head Distal part of the dendritic spine, that carries the post-synaptic density. NIF_Subcellular:sao952643730 go.json spine head http://purl.obolibrary.org/obo/GO_0044327 GO:0010982 biolink:BiologicalProcess regulation of high-density lipoprotein particle clearance Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0010982 GO:0009998 biolink:BiologicalProcess negative regulation of retinal cone cell fate specification Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell. go.json down regulation of retinal cone cell fate specification|down-regulation of retinal cone cell fate specification|downregulation of retinal cone cell fate specification|inhibition of retinal cone cell fate specification|negative regulation of retina cone cell fate specification|suppression of retina cone cell fate|suppression of retinal cone cell fate http://purl.obolibrary.org/obo/GO_0009998 GO:0019313 biolink:BiologicalProcess allose metabolic process The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. go.json allose metabolism http://purl.obolibrary.org/obo/GO_0019313 GO:0009999 biolink:BiologicalProcess negative regulation of auditory receptor cell fate specification Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell. go.json down regulation of auditory receptor cell fate specification|down-regulation of auditory receptor cell fate specification|downregulation of auditory receptor cell fate specification|inhibition of auditory receptor cell fate specification|negative regulation of auditory hair cell fate specification|suppression of auditory receptor cell fate|suppression of hair cell fate http://purl.obolibrary.org/obo/GO_0009999 GO:0019314 biolink:BiologicalProcess D-allose metabolic process The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose. go.json D-allose metabolism http://purl.obolibrary.org/obo/GO_0019314 GO:0019311 biolink:BiologicalProcess sorbose metabolic process The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. go.json sorbose metabolism http://purl.obolibrary.org/obo/GO_0019311 GO:0019312 biolink:BiologicalProcess L-sorbose metabolic process The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. MetaCyc:P302-PWY go.json L-sorbose metabolism http://purl.obolibrary.org/obo/GO_0019312 GO:0019310 biolink:BiologicalProcess inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. MetaCyc:P562-PWY go.json inositol breakdown|inositol catabolism|inositol degradation|myo-inositol catabolic process|myo-inositol catabolism|vitamin Bh catabolic process|vitamin Bh catabolism http://purl.obolibrary.org/obo/GO_0019310 GO:0044335 biolink:BiologicalProcess canonical Wnt signaling pathway involved in neural crest cell differentiation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation. go.json canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|canonical Wnt receptor signalling pathway involved in neural crest cell differentiation|canonical Wnt-activated signaling pathway involved in neural crest cell differentiation http://purl.obolibrary.org/obo/GO_0044335 GO:0034943 biolink:MolecularActivity trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi. UM-BBD_reactionID:r0989 go.json http://purl.obolibrary.org/obo/GO_0034943 GO:0010998 biolink:BiologicalProcess regulation of translational initiation by eIF2 alpha phosphorylation Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. go.json eIF2 alpha phosphorylation in response to stress|regulation of translational initiation by eIF2 alpha phosphorylation in response to stress http://purl.obolibrary.org/obo/GO_0010998 gocheck_do_not_annotate GO:0044336 biolink:BiologicalProcess canonical Wnt signaling pathway involved in negative regulation of apoptotic process The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process. go.json canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process|canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis http://purl.obolibrary.org/obo/GO_0044336 GO:0010999 biolink:BiologicalProcess regulation of eIF2 alpha phosphorylation by heme Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels. go.json http://purl.obolibrary.org/obo/GO_0010999 GO:0034944 biolink:MolecularActivity 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+. UM-BBD_reactionID:r0986 go.json http://purl.obolibrary.org/obo/GO_0034944 GO:0044333 biolink:BiologicalProcess Wnt signaling pathway involved in digestive tract morphogenesis The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract. go.json Wnt receptor signaling pathway involved in digestive tract morphogenesis|Wnt receptor signalling pathway involved in digestive tract morphogenesis|Wnt-activated signaling pathway involved in digestive tract morphogenesis http://purl.obolibrary.org/obo/GO_0044333 GO:0010996 biolink:BiologicalProcess response to auditory stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. go.json response to sound|response to sound stimulus http://purl.obolibrary.org/obo/GO_0010996 GO:0034945 biolink:MolecularActivity 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA. EC:2.3.1.-|UM-BBD_reactionID:r0987 go.json http://purl.obolibrary.org/obo/GO_0034945 GO:0010997 biolink:MolecularActivity anaphase-promoting complex binding Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. go.json APC binding http://purl.obolibrary.org/obo/GO_0010997 GO:0034946 biolink:MolecularActivity 3-isopropylbut-3-enoyl-CoA thioesterase activity Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH. UM-BBD_reactionID:r0994 go.json http://purl.obolibrary.org/obo/GO_0034946 GO:0044334 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition. go.json canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition|canonical Wnt-activated signaling pathway involved in positive regulation of epithelial to mesenchymal transition http://purl.obolibrary.org/obo/GO_0044334 GO:0044331 biolink:BiologicalProcess cell-cell adhesion mediated by cadherin The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. go.json http://purl.obolibrary.org/obo/GO_0044331 GO:0034947 biolink:MolecularActivity terephthalate decarboxylase activity Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-. UM-BBD_reactionID:r0321 go.json http://purl.obolibrary.org/obo/GO_0034947 GO:0034948 biolink:MolecularActivity 2,6-dihydroxypseudooxynicotine hydrolase activity Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate. EC:3.7.1.-|UM-BBD_reactionID:r0482 go.json http://purl.obolibrary.org/obo/GO_0034948 GO:0044332 biolink:BiologicalProcess Wnt signaling pathway involved in dorsal/ventral axis specification The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis. go.json Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signalling pathway involved in dorsal/ventral axis specification|Wnt-activated signaling pathway involved in dorsal/ventral axis specification http://purl.obolibrary.org/obo/GO_0044332 GO:0034949 biolink:MolecularActivity 1,1-dichloroethane reductive dehalogenase activity Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl. EC:1.97.1.-|UM-BBD_reactionID:r1008 go.json http://purl.obolibrary.org/obo/GO_0034949 GO:0044330 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of wound healing The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing. go.json canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|canonical Wnt receptor signalling pathway involved in positive regulation of wound healing|canonical Wnt-activated signaling pathway involved in positive regulation of wound healing http://purl.obolibrary.org/obo/GO_0044330 GO:0010990 biolink:BiologicalProcess obsolete regulation of SMAD protein complex assembly OBSOLETE. Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. go.json True http://purl.obolibrary.org/obo/GO_0010990 GO:0010991 biolink:BiologicalProcess obsolete negative regulation of SMAD protein complex assembly OBSOLETE. Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. go.json True http://purl.obolibrary.org/obo/GO_0010991 GO:0044339 biolink:BiologicalProcess canonical Wnt signaling pathway involved in osteoblast differentiation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation. go.json canonical Wnt receptor signaling pathway involved in osteoblast differentiation|canonical Wnt receptor signalling pathway involved in osteoblast differentiation|canonical Wnt-activated signaling pathway involved in osteoblast differentiation http://purl.obolibrary.org/obo/GO_0044339 GO:0010994 biolink:BiologicalProcess free ubiquitin chain polymerization The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein. go.json http://purl.obolibrary.org/obo/GO_0010994 GO:0019328 biolink:BiologicalProcess anaerobic gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen. MetaCyc:P3-PWY go.json anaerobic gallate breakdown|anaerobic gallate catabolism|anaerobic gallate degradation|anaerobic gallic acid catabolic process|anaerobic gallic acid catabolism|gallate fermentation http://purl.obolibrary.org/obo/GO_0019328 GO:0034940 biolink:MolecularActivity 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3. UM-BBD_reactionID:r0984 go.json http://purl.obolibrary.org/obo/GO_0034940 GO:0010995 biolink:BiologicalProcess free ubiquitin chain depolymerization The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down. go.json http://purl.obolibrary.org/obo/GO_0010995 GO:0019329 biolink:BiologicalProcess ammonia oxidation The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons. go.json http://purl.obolibrary.org/obo/GO_0019329 GO:0044337 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of apoptotic process The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process. go.json canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process|canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis|canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process http://purl.obolibrary.org/obo/GO_0044337 GO:0034941 biolink:MolecularActivity pyrrole-2-carboxylate decarboxylase activity Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2. EC:4.1.1.93|UM-BBD_reactionID:r0970 go.json http://purl.obolibrary.org/obo/GO_0034941 GO:0010992 biolink:BiologicalProcess ubiquitin recycling Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates. go.json regulation of ubiquitin homeostasis|ubiquitin homeostasis http://purl.obolibrary.org/obo/GO_0010992 GO:0019326 biolink:BiologicalProcess nitrotoluene metabolic process The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. go.json nitrotoluene metabolism http://purl.obolibrary.org/obo/GO_0019326 GO:0019327 biolink:BiologicalProcess lead sulfide oxidation The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate. MetaCyc:P301-PWY go.json lead sulphide oxidation|oxidation of galena|oxidation of lead sulfide http://purl.obolibrary.org/obo/GO_0019327 GO:0044338 biolink:BiologicalProcess canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation. go.json canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation|canonical Wnt-activated signaling pathway involved in mesenchymal stem cell differentiation http://purl.obolibrary.org/obo/GO_0044338 GO:0034942 biolink:MolecularActivity cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi. UM-BBD_reactionID:r0988 go.json http://purl.obolibrary.org/obo/GO_0034942 GO:0010993 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010993 GO:0019324 biolink:BiologicalProcess L-lyxose metabolic process The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose. MetaCyc:LYXMET-PWY go.json L-lyxose metabolism http://purl.obolibrary.org/obo/GO_0019324 GO:0019325 biolink:BiologicalProcess anaerobic fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen. MetaCyc:ANAEROFRUCAT-PWY go.json anaerobic fructose breakdown|anaerobic fructose catabolism|anaerobic fructose degradation http://purl.obolibrary.org/obo/GO_0019325 GO:0019322 biolink:BiologicalProcess pentose biosynthetic process The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. go.json pentose anabolism|pentose biosynthesis|pentose formation|pentose synthesis http://purl.obolibrary.org/obo/GO_0019322 GO:0019323 biolink:BiologicalProcess pentose catabolic process The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. go.json pentose breakdown|pentose catabolism|pentose degradation http://purl.obolibrary.org/obo/GO_0019323 GO:0019320 biolink:BiologicalProcess hexose catabolic process The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. go.json hexose breakdown|hexose catabolism|hexose degradation http://purl.obolibrary.org/obo/GO_0019320 GO:0019321 biolink:BiologicalProcess pentose metabolic process The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. go.json pentose metabolism http://purl.obolibrary.org/obo/GO_0019321 GO:0044346 biolink:BiologicalProcess fibroblast apoptotic process Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. go.json fibroblast apoptosis http://purl.obolibrary.org/obo/GO_0044346 GO:0034932 biolink:MolecularActivity 1-methoxypyrene 6,7-monooxygenase activity Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O. UM-BBD_reactionID:r0954 go.json http://purl.obolibrary.org/obo/GO_0034932 GO:0010965 biolink:BiologicalProcess regulation of mitotic sister chromatid separation Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis. go.json http://purl.obolibrary.org/obo/GO_0010965 GO:0044347 biolink:BiologicalProcess cell wall polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides. go.json cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_0044347 GO:0034933 biolink:MolecularActivity 1-hydroxy-6-methoxypyrene methyltransferase activity Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX. UM-BBD_reactionID:r0956 go.json http://purl.obolibrary.org/obo/GO_0034933 GO:0010966 biolink:BiologicalProcess regulation of phosphate transport Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010966 GO:0034934 biolink:MolecularActivity phenanthrene-4-carboxylate dioxygenase activity Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate. EC:1.13.11.-|UM-BBD_reactionID:r0939 go.json http://purl.obolibrary.org/obo/GO_0034934 GO:0010963 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010963 GO:0044344 biolink:BiologicalProcess cellular response to fibroblast growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. go.json cellular response to FGF stimulus http://purl.obolibrary.org/obo/GO_0044344 GO:0010964 biolink:BiologicalProcess regulation of regulatory ncRNA-mediated heterochromatin formation Any process that modulates the frequency, rate or extent of small non-coding RNA-mediated heterochromatin formation. go.json regulation of RNAi-mediated heterochromatin assembly|regulation of chromatin silencing by small RNA|regulation of heterochromatin assembly by small RNA|regulation of ncRNA-mediated heterochromatin formation|regulation of small non-coding RNA-mediated heterochromatin formation http://purl.obolibrary.org/obo/GO_0010964 GO:0034935 biolink:MolecularActivity tetrachlorobenzene dioxygenase activity Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+. EC:1.13.11.-|UM-BBD_reactionID:r0957 go.json http://purl.obolibrary.org/obo/GO_0034935 GO:0044345 biolink:BiologicalProcess stromal-epithelial cell signaling involved in prostate gland development The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development. go.json stromal-epithelial cell signalling involved in prostate gland development http://purl.obolibrary.org/obo/GO_0044345 GO:0034936 biolink:MolecularActivity 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+. EC:1.13.11.-|UM-BBD_reactionID:r0959 go.json http://purl.obolibrary.org/obo/GO_0034936 GO:0044342 biolink:BiologicalProcess type B pancreatic cell proliferation The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. go.json pancreatic B cell proliferation|pancreatic beta cell proliferation http://purl.obolibrary.org/obo/GO_0044342 GO:0010969 biolink:BiologicalProcess regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0010969 GO:0034937 biolink:MolecularActivity perchlorate reductase activity Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O. EC:1.97.1.-|UM-BBD_reactionID:r0980 go.json http://purl.obolibrary.org/obo/GO_0034937 GO:0044343 biolink:BiologicalProcess canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin. go.json canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation|canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation|canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation|canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation|canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation|canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation http://purl.obolibrary.org/obo/GO_0044343 GO:0010967 biolink:BiologicalProcess regulation of polyamine biosynthetic process Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. go.json http://purl.obolibrary.org/obo/GO_0010967 GO:0034938 biolink:MolecularActivity pyrrole-2-carboxylate monooxygenase activity Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O. EC:1.14.14.-|UM-BBD_reactionID:r0968 go.json http://purl.obolibrary.org/obo/GO_0034938 GO:0044340 biolink:BiologicalProcess canonical Wnt signaling pathway involved in regulation of cell proliferation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation. go.json canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|canonical Wnt receptor signalling pathway involved in regulation of cell proliferation|canonical Wnt-activated signaling pathway involved in regulation of cell proliferation http://purl.obolibrary.org/obo/GO_0044340 GO:0034939 biolink:MolecularActivity 5-hydroxypyrrole-2-carboxylate tautomerase activity Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate. UM-BBD_reactionID:r0969 go.json http://purl.obolibrary.org/obo/GO_0034939 GO:0010968 biolink:BiologicalProcess regulation of microtubule nucleation Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. go.json http://purl.obolibrary.org/obo/GO_0010968 GO:0044341 biolink:BiologicalProcess sodium-dependent phosphate transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. go.json http://purl.obolibrary.org/obo/GO_0044341 GO:0009970 biolink:BiologicalProcess cellular response to sulfate starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate. go.json cellular response to sulphate starvation http://purl.obolibrary.org/obo/GO_0009970 GO:0009971 biolink:BiologicalProcess anastral spindle assembly involved in male meiosis The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells. go.json http://purl.obolibrary.org/obo/GO_0009971 GO:0009972 biolink:BiologicalProcess cytidine deamination The removal of amino group in the presence of water. go.json http://purl.obolibrary.org/obo/GO_0009972 GO:0010961 biolink:BiologicalProcess intracellular magnesium ion homeostasis A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell. go.json cellular magnesium ion homeostasis http://purl.obolibrary.org/obo/GO_0010961 GO:0010962 biolink:BiologicalProcess regulation of glucan biosynthetic process Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. go.json http://purl.obolibrary.org/obo/GO_0010962 GO:0009973 biolink:MolecularActivity adenylyl-sulfate reductase activity Catalysis of the reaction: A + AMP + 2 H+ + sulfite = adenosine 5'-phosphosulfate + AH2. EC:1.8.99.2|MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN|RHEA:24240 go.json APS reductase activity|adenosine phosphosulfate reductase activity|adenylyl-sulphate reductase activity http://purl.obolibrary.org/obo/GO_0009973 GO:0009974 biolink:MolecularActivity zeinoxanthin epsilon hydroxylase activity Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. EC:1.14.14.158|MetaCyc:RXN-5962|RHEA:57352 go.json http://purl.obolibrary.org/obo/GO_0009974 GO:0034930 biolink:MolecularActivity 1-hydroxypyrene sulfotransferase activity Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX. UM-BBD_reactionID:r0952 go.json http://purl.obolibrary.org/obo/GO_0034930 GO:0044348 biolink:BiologicalProcess plant-type cell wall cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall. go.json plant-type cell wall polysaccharide breakdown http://purl.obolibrary.org/obo/GO_0044348 GO:0010960 biolink:BiologicalProcess magnesium ion homeostasis Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0010960 GO:0044349 biolink:BiologicalProcess DNA excision The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised. go.json http://purl.obolibrary.org/obo/GO_0044349 GO:0009975 biolink:MolecularActivity cyclase activity Catalysis of a ring closure reaction. go.json http://purl.obolibrary.org/obo/GO_0009975 goslim_generic|goslim_pir|prokaryote_subset GO:0034931 biolink:MolecularActivity 1-hydroxypyrene methyltransferase activity Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX. UM-BBD_reactionID:r0953 go.json http://purl.obolibrary.org/obo/GO_0034931 GO:0009976 biolink:MolecularActivity tocopherol cyclase activity Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol). go.json http://purl.obolibrary.org/obo/GO_0009976 GO:0009977 biolink:MolecularActivity proton motive force dependent protein transmembrane transporter activity Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane. go.json arginine targeting transmembrane transporter activity|delta-pH-dependent protein transporter activity|pH-dependent protein transporter activity|twin-arginine targeting transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0009977 GO:0009978 biolink:MolecularActivity allene oxide synthase activity Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O. EC:4.2.1.92|MetaCyc:RXN1F-19|RHEA:25074 go.json (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]|(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity|HPI|hydroperoxide dehydratase activity|hydroperoxide isomerase activity|linoleate hydroperoxide isomerase|linoleic acid hydroperoxide isomerase http://purl.obolibrary.org/obo/GO_0009978 GO:0009979 biolink:MolecularActivity 16:0 monogalactosyldiacylglycerol desaturase activity Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule. go.json http://purl.obolibrary.org/obo/GO_0009979 GO:0034929 biolink:MolecularActivity 1-hydroxypyrene 7,8-monooxygenase activity Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O. UM-BBD_reactionID:r0949 go.json http://purl.obolibrary.org/obo/GO_0034929 GO:0044350 biolink:BiologicalProcess micropinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm. go.json clathrin-independent pinocytosis|single-organism micropinocytosis http://purl.obolibrary.org/obo/GO_0044350 GO:0034921 biolink:MolecularActivity cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-. UM-BBD_reactionID:r0935 go.json http://purl.obolibrary.org/obo/GO_0034921 GO:0044357 biolink:BiologicalProcess regulation of rRNA stability Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs. go.json regulation of ribosomal RNA stability http://purl.obolibrary.org/obo/GO_0044357 GO:0010976 biolink:BiologicalProcess positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). go.json positive regulation of neurite biosynthesis|positive regulation of neurite development|positive regulation of neurite formation|positive regulation of neurite growth http://purl.obolibrary.org/obo/GO_0010976 GO:0044358 biolink:BiologicalProcess envenomation resulting in hemorrhagic damage in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism. go.json envenomation resulting in hemorrhagic damage to other organism http://purl.obolibrary.org/obo/GO_0044358 GO:0034922 biolink:MolecularActivity 4,5-dihydroxypyrene dioxygenase activity Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+. EC:1.13.11.-|UM-BBD_reactionID:r0936 go.json http://purl.obolibrary.org/obo/GO_0034922 GO:0010977 biolink:BiologicalProcess negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). go.json growth cone collapse|negative regulation of neurite biosynthesis|negative regulation of neurite development|negative regulation of neurite formation|negative regulation of neurite growth http://purl.obolibrary.org/obo/GO_0010977 GO:0044355 biolink:BiologicalProcess clearance of foreign intracellular DNA A defense process that protects an organism from invading foreign DNA. go.json clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine http://purl.obolibrary.org/obo/GO_0044355 GO:0034923 biolink:MolecularActivity phenanthrene-4,5-dicarboxylate decarboxylase activity Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2. UM-BBD_reactionID:r0937 go.json http://purl.obolibrary.org/obo/GO_0034923 GO:0010974 biolink:BiologicalProcess negative regulation of division septum assembly Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. go.json inhibition of division septum assembly involved in cell cycle cytokinesis|negative regulation of division septum formation http://purl.obolibrary.org/obo/GO_0010974 GO:0034924 biolink:MolecularActivity cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2. UM-BBD_reactionID:r0940 go.json http://purl.obolibrary.org/obo/GO_0034924 GO:0010975 biolink:BiologicalProcess regulation of neuron projection development Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). go.json regulation of neurite biosynthesis|regulation of neurite development|regulation of neurite formation|regulation of neurite growth http://purl.obolibrary.org/obo/GO_0010975 GO:0044356 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044356 GO:0034925 biolink:MolecularActivity pyrene 4,5-monooxygenase activity Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O. UM-BBD_reactionID:r0941 go.json http://purl.obolibrary.org/obo/GO_0034925 GO:0044353 biolink:CellularComponent micropinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis. go.json http://purl.obolibrary.org/obo/GO_0044353 GO:0034926 biolink:MolecularActivity pyrene-4,5-epoxide hydrolase activity Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene. UM-BBD_reactionID:r0942 go.json http://purl.obolibrary.org/obo/GO_0034926 GO:0044354 biolink:CellularComponent macropinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis. go.json http://purl.obolibrary.org/obo/GO_0044354 GO:0044351 biolink:BiologicalProcess macropinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. go.json clathrin-independent pinocytosis|single-organism macropinocytosis http://purl.obolibrary.org/obo/GO_0044351 GO:0010978 biolink:BiologicalProcess obsolete gene silencing involved in chronological cell aging OBSOLETE. Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation. go.json True http://purl.obolibrary.org/obo/GO_0010978 GO:0034927 biolink:MolecularActivity pyrene 1,2-monooxygenase activity Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O. UM-BBD_reactionID:r0943 go.json http://purl.obolibrary.org/obo/GO_0034927 GO:0010979 biolink:BiologicalProcess regulation of vitamin D 24-hydroxylase activity Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D. go.json http://purl.obolibrary.org/obo/GO_0010979 gocheck_do_not_annotate GO:0044352 biolink:CellularComponent pinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis. NIF_Subcellular:sao1925368674 go.json pinocytic vesicle http://purl.obolibrary.org/obo/GO_0044352 GO:0034928 biolink:MolecularActivity 1-hydroxypyrene 6,7-monooxygenase activity Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O. UM-BBD_reactionID:r0946 go.json http://purl.obolibrary.org/obo/GO_0034928 GO:0009980 biolink:MolecularActivity obsolete glutamate carboxypeptidase activity OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups. go.json N-pteroyl-L-glutamate hydrolase activity|carboxypeptidase G activity|carboxypeptidase G1 activity|carboxypeptidase G2 activity|glutamate carboxypeptidase activity|glutamyl carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0009980 GO:0019308 biolink:BiologicalProcess dTDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate. go.json dTDP-mannose anabolism|dTDP-mannose biosynthesis|dTDP-mannose formation|dTDP-mannose synthesis http://purl.obolibrary.org/obo/GO_0019308 GO:0009981 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009981 GO:0019309 biolink:BiologicalProcess mannose catabolic process The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. MetaCyc:MANNCAT-PWY go.json mannose breakdown|mannose catabolism|mannose degradation http://purl.obolibrary.org/obo/GO_0019309 GO:0009982 biolink:MolecularActivity pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. Reactome:R-HSA-6782381|Reactome:R-HSA-6786583|Reactome:R-HSA-6787566|Reactome:R-HSA-6790905|Reactome:R-HSA-8870289 go.json http://purl.obolibrary.org/obo/GO_0009982 GO:0010972 biolink:BiologicalProcess negative regulation of G2/M transition of mitotic cell cycle Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. go.json negative regulation of mitotic entry http://purl.obolibrary.org/obo/GO_0010972 GO:0019306 biolink:BiologicalProcess GDP-D-rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate. MetaCyc:GDPRHAMSYN-PWY go.json GDP-D-rhamnose anabolism|GDP-D-rhamnose biosynthesis|GDP-D-rhamnose formation|GDP-D-rhamnose synthesis http://purl.obolibrary.org/obo/GO_0019306 GO:0009983 biolink:MolecularActivity obsolete tyrosine aminopeptidase activity OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide. go.json tyrosine aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0009983 GO:0019307 biolink:BiologicalProcess mannose biosynthetic process The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. go.json mannose anabolism|mannose biosynthesis|mannose formation|mannose synthesis http://purl.obolibrary.org/obo/GO_0019307 GO:0009984 biolink:MolecularActivity obsolete adenylate forming enzyme activity OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate. go.json adenylate forming enzyme activity True http://purl.obolibrary.org/obo/GO_0009984 GO:0010973 biolink:BiologicalProcess positive regulation of division septum assembly Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. go.json positive regulation of division septum formation|positive regulation of division septum formation involved in cell cycle cytokinesis|upregulation of mitotic division septum assembly http://purl.obolibrary.org/obo/GO_0010973 GO:0019304 biolink:BiologicalProcess anaerobic rhamnose catabolic process The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen. go.json anaerobic rhamnose breakdown|anaerobic rhamnose catabolism|anaerobic rhamnose degradation http://purl.obolibrary.org/obo/GO_0019304 GO:0010970 biolink:BiologicalProcess transport along microtubule The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. go.json establishment of localization by movement along microtubule|microtubule-based transport|movement along microtubule http://purl.obolibrary.org/obo/GO_0010970 GO:0009985 biolink:MolecularActivity obsolete dihydroflavonol(thiole) lyase activity OBSOLETE. (Was not defined before being made obsolete). go.json dihydroflavonol(thiole) lyase activity True http://purl.obolibrary.org/obo/GO_0009985 GO:0044359 biolink:BiologicalProcess modulation of molecular function in another organism The process in which an organism effects a change in the function of proteins in a second organism. go.json modulation of molecular function in other organism http://purl.obolibrary.org/obo/GO_0044359 GO:0019305 biolink:BiologicalProcess dTDP-rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. MetaCyc:DTDPRHAMSYN-PWY go.json dTDP-rhamnose anabolism|dTDP-rhamnose biosynthesis|dTDP-rhamnose formation|dTDP-rhamnose synthesis http://purl.obolibrary.org/obo/GO_0019305 GO:0010971 biolink:BiologicalProcess positive regulation of G2/M transition of mitotic cell cycle Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. go.json positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle|positive regulation of mitotic entry http://purl.obolibrary.org/obo/GO_0010971 GO:0009986 biolink:CellularComponent cell surface The external part of the cell wall and/or plasma membrane. go.json cell associated|cell bound http://purl.obolibrary.org/obo/GO_0009986 goslim_pir GO:0034920 biolink:MolecularActivity pyrene dioxygenase activity Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene. EC:1.13.11.-|UM-BBD_reactionID:r0934 go.json http://purl.obolibrary.org/obo/GO_0034920 GO:0009987 biolink:BiologicalProcess cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. go.json cell growth and/or maintenance|cell physiology|cellular physiological process|single-organism cellular process http://purl.obolibrary.org/obo/GO_0009987 gocheck_do_not_annotate|goslim_plant GO:0019302 biolink:BiologicalProcess D-ribose biosynthetic process The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose). go.json D-ribose anabolism|D-ribose biosynthesis|D-ribose formation|D-ribose synthesis http://purl.obolibrary.org/obo/GO_0019302 GO:0009988 biolink:BiologicalProcess cell-cell recognition Cell recognition between cells. May involve the formation of specialized cell junctions. go.json http://purl.obolibrary.org/obo/GO_0009988 GO:0019303 biolink:BiologicalProcess D-ribose catabolic process The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose). MetaCyc:RIBOKIN-PWY go.json D-ribose breakdown|D-ribose catabolism|D-ribose degradation http://purl.obolibrary.org/obo/GO_0019303 GO:0019300 biolink:BiologicalProcess rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose. go.json rhamnose anabolism|rhamnose biosynthesis|rhamnose formation|rhamnose synthesis http://purl.obolibrary.org/obo/GO_0019300 GO:0009989 biolink:BiologicalProcess cell-matrix recognition Cell recognition that involves the interaction of the cell with the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0009989 GO:0019301 biolink:BiologicalProcess rhamnose catabolic process The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. MetaCyc:RHAMCAT-PWY go.json rhamnose breakdown|rhamnose catabolism|rhamnose degradation http://purl.obolibrary.org/obo/GO_0019301 GO:0044360 biolink:BiologicalProcess modulation of voltage-gated potassium channel activity in another organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism. go.json modulation of voltage-gated potassium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044360 GO:0034918 biolink:MolecularActivity 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-. UM-BBD_reactionID:r0930 go.json http://purl.obolibrary.org/obo/GO_0034918 GO:0044361 biolink:BiologicalProcess negative regulation of voltage-gated potassium channel activity in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism. go.json negative regulation of voltage-gated potassium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044361 gocheck_do_not_annotate GO:0034919 biolink:MolecularActivity butyryl-CoA 2-C-propionyltransferase activity Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA. UM-BBD_reactionID:r0931 go.json http://purl.obolibrary.org/obo/GO_0034919 GO:0010949 biolink:BiologicalProcess negative regulation of intestinal phytosterol absorption Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine. go.json http://purl.obolibrary.org/obo/GO_0010949 GO:0034910 biolink:MolecularActivity 6-hydroxy-3-succinoylpyridine hydrolase activity Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine. UM-BBD_reactionID:r1442 go.json http://purl.obolibrary.org/obo/GO_0034910 GO:0044368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044368 GO:0010943 biolink:MolecularActivity NADPH pyrophosphatase activity Catalysis of the reaction: NADPH + H2O = NMNH + ADP. go.json http://purl.obolibrary.org/obo/GO_0010943 GO:0044369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044369 GO:0034911 biolink:MolecularActivity phthalate 3,4-dioxygenase activity Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+. EC:1.14.12.-|UM-BBD_reactionID:r1444 go.json http://purl.obolibrary.org/obo/GO_0034911 GO:0010944 biolink:BiologicalProcess negative regulation of transcription by competitive promoter binding Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site. go.json http://purl.obolibrary.org/obo/GO_0010944 GO:0034912 biolink:MolecularActivity phthalate 3,4-cis-dihydrodiol dehydrogenase activity Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+. MetaCyc:RXN5F9-56|UM-BBD_reactionID:r1445 go.json http://purl.obolibrary.org/obo/GO_0034912 GO:0044366 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044366 GO:0010941 biolink:BiologicalProcess obsolete regulation of cell death OBSOLETE. Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. go.json True http://purl.obolibrary.org/obo/GO_0010941 GO:0044367 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044367 GO:0010942 biolink:BiologicalProcess obsolete positive regulation of cell death OBSOLETE. Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. go.json True http://purl.obolibrary.org/obo/GO_0010942 GO:0034913 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034913 GO:0010947 biolink:BiologicalProcess negative regulation of meiotic joint molecule formation Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. go.json http://purl.obolibrary.org/obo/GO_0010947 GO:0034914 biolink:MolecularActivity trinitrophenol hydride denitratase activity Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP. EC:1.7.99.-|UM-BBD_reactionID:r1448 go.json 2,4,6-trinitrophenol hydride denitratase activity|TNP hydride denitratase activity http://purl.obolibrary.org/obo/GO_0034914 GO:0044364 biolink:BiologicalProcess obsolete disruption of cells of another organism OBSOLETE. A process in which an organism has a negative effect on the functioning of the second organism's cells. go.json disruption of cells of other organism True http://purl.obolibrary.org/obo/GO_0044364 GO:0044365 biolink:BiologicalProcess envenomation resulting in modulation of platelet aggregation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism. go.json envenomation resulting in modulation of platelet aggregation in other organism|envenomation resulting in regulation of platelet aggregation in other organism http://purl.obolibrary.org/obo/GO_0044365 GO:0034915 biolink:MolecularActivity 2-methylhexanoyl-CoA C-acetyltransferase activity Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA. EC:2.3.1.-|UM-BBD_reactionID:r0927 go.json http://purl.obolibrary.org/obo/GO_0034915 GO:0010948 biolink:BiologicalProcess negative regulation of cell cycle process Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. go.json http://purl.obolibrary.org/obo/GO_0010948 GO:0044362 biolink:BiologicalProcess negative regulation of molecular function in another organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism. go.json negative regulation of molecular function in other organism http://purl.obolibrary.org/obo/GO_0044362 gocheck_do_not_annotate GO:0034916 biolink:MolecularActivity 2-methylhexanoyl-CoA dehydrogenase activity Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-. EC:1.3.99.-|UM-BBD_reactionID:r0928 go.json http://purl.obolibrary.org/obo/GO_0034916 GO:0010945 biolink:MolecularActivity CoA pyrophosphatase activity Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine. Reactome:R-HSA-6809354|Reactome:R-HSA-6810474 go.json conezyme A pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0010945 GO:0010946 biolink:BiologicalProcess regulation of meiotic joint molecule formation Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. go.json http://purl.obolibrary.org/obo/GO_0010946 GO:0034917 biolink:MolecularActivity 2-methylhex-2-enoyl-CoA hydratase activity Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA. UM-BBD_reactionID:r0929 go.json http://purl.obolibrary.org/obo/GO_0034917 GO:0044363 biolink:BiologicalProcess modulation of potassium channel activity in another organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism. go.json modulation of potassium channel activity in other organism http://purl.obolibrary.org/obo/GO_0044363 GO:0009950 biolink:BiologicalProcess dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. go.json dorsal-ventral axis specification|dorsal/ventral axis determination|dorsoventral axis specification http://purl.obolibrary.org/obo/GO_0009950 GO:0009951 biolink:BiologicalProcess polarity specification of dorsal/ventral axis Any process resulting in the establishment of polarity along the dorsal/ventral axis. go.json polarity specification of dorsal-ventral axis|polarity specification of dorsoventral axis http://purl.obolibrary.org/obo/GO_0009951 GO:0010940 biolink:BiologicalProcess obsolete positive regulation of necrotic cell death OBSOLETE. Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. go.json True http://purl.obolibrary.org/obo/GO_0010940 GO:0009952 biolink:BiologicalProcess anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. go.json anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0009952 GO:0009953 biolink:BiologicalProcess dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. go.json dorsal-ventral pattern formation|dorsal/ventral pattern specification|dorsoventral pattern formation http://purl.obolibrary.org/obo/GO_0009953 GO:0009954 biolink:BiologicalProcess proximal/distal pattern formation The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). go.json proximal/distal pattern specification http://purl.obolibrary.org/obo/GO_0009954 GO:0009955 biolink:BiologicalProcess adaxial/abaxial pattern specification The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. go.json adaxial/abaxial pattern formation http://purl.obolibrary.org/obo/GO_0009955 GO:0009956 biolink:BiologicalProcess radial pattern formation The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur. go.json radial pattern specification http://purl.obolibrary.org/obo/GO_0009956 GO:0009957 biolink:BiologicalProcess epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json hypodermal cell fate specification http://purl.obolibrary.org/obo/GO_0009957 GO:0009958 biolink:BiologicalProcess positive gravitropism The orientation of plant parts towards gravity. go.json root gravitropism http://purl.obolibrary.org/obo/GO_0009958 GO:0009959 biolink:BiologicalProcess negative gravitropism The orientation of plant parts away from gravity. go.json shoot gravitropism http://purl.obolibrary.org/obo/GO_0009959 GO:0044371 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044371 GO:0034907 biolink:MolecularActivity acetanilide 1,2-dioxygenase activity Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide. EC:1.14.12.-|UM-BBD_reactionID:r0723 go.json http://purl.obolibrary.org/obo/GO_0034907 GO:0044372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044372 GO:0034908 biolink:MolecularActivity 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+. EC:1.14.12.-|UM-BBD_reactionID:r0724 go.json http://purl.obolibrary.org/obo/GO_0034908 GO:0034909 biolink:MolecularActivity 6-hydroxypseudooxynicotine dehydrogenase activity Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine. EC:1.5.99.14|RHEA:34223|UM-BBD_reactionID:r1441 go.json http://purl.obolibrary.org/obo/GO_0034909 GO:0044370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044370 GO:0010954 biolink:BiologicalProcess positive regulation of protein processing Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. go.json positive regulation of protein maturation by peptide bond cleavage http://purl.obolibrary.org/obo/GO_0010954 GO:0044379 biolink:BiologicalProcess protein localization to actin cortical patch A process in which a protein is transported to, or maintained in, an actin cortical patch. go.json protein localisation to actin cortical patch http://purl.obolibrary.org/obo/GO_0044379 GO:0010955 biolink:BiologicalProcess negative regulation of protein processing Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. go.json negative regulation of protein maturation by peptide bond cleavage http://purl.obolibrary.org/obo/GO_0010955 GO:0034900 biolink:MolecularActivity 3-(N-formyl)-formiminopyruvate hydrolase activity Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate. EC:3.5.99.-|UM-BBD_reactionID:r1399 go.json http://purl.obolibrary.org/obo/GO_0034900 GO:0044377 biolink:MolecularActivity RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. go.json RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II proximal promoter region sequence-specific DNA binding, bending|RNA polymerase II proximal promoter sequence-specific DNA binding, bending http://purl.obolibrary.org/obo/GO_0044377 GO:0010952 biolink:BiologicalProcess positive regulation of peptidase activity Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. go.json http://purl.obolibrary.org/obo/GO_0010952 gocheck_do_not_annotate GO:0034901 biolink:MolecularActivity endosulfan hydroxyether dehydrogenase activity Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-. UM-BBD_reactionID:r1411 go.json http://purl.obolibrary.org/obo/GO_0034901 GO:0044378 biolink:MolecularActivity non-sequence-specific DNA binding, bending The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. go.json DNA bending involving non-sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0044378 GO:0034902 biolink:MolecularActivity endosulfan sulfate hydrolase activity Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite. UM-BBD_reactionID:r1387 go.json http://purl.obolibrary.org/obo/GO_0034902 GO:0010953 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010953 GO:0010958 biolink:BiologicalProcess regulation of amino acid import across plasma membrane Any process that modulates the frequency, rate or extent of amino acid import into a cell. go.json regulation of amino acid import http://purl.obolibrary.org/obo/GO_0010958 GO:0044375 biolink:BiologicalProcess regulation of peroxisome size Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. go.json http://purl.obolibrary.org/obo/GO_0044375 GO:0034903 biolink:MolecularActivity endosulfan ether monooxygenase activity Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O. UM-BBD_reactionID:r1413 go.json http://purl.obolibrary.org/obo/GO_0034903 GO:0034904 biolink:MolecularActivity 5-chloro-2-oxopent-4-enoate hydratase activity Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate. UM-BBD_reactionID:r1436 go.json http://purl.obolibrary.org/obo/GO_0034904 GO:0044376 biolink:BiologicalProcess obsolete RNA polymerase II complex import to nucleus OBSOLETE. The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus. go.json DNA-directed RNA polymerase II core complex import into nucleus|DNA-directed RNA polymerase II core complex localization to nucleus|RNA polymerase II complex import into nucleus|RNA polymerase II complex localisation to nucleus True http://purl.obolibrary.org/obo/GO_0044376 GO:0010959 biolink:BiologicalProcess regulation of metal ion transport Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0010959 GO:0034905 biolink:MolecularActivity 5-chloro-4-hydroxy-2-oxopentanate aldolase activity Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde. EC:4.1.3.-|UM-BBD_reactionID:r1437 go.json http://purl.obolibrary.org/obo/GO_0034905 GO:0044373 biolink:MolecularActivity cytokinin binding Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators. go.json http://purl.obolibrary.org/obo/GO_0044373 GO:0010956 biolink:BiologicalProcess negative regulation of calcidiol 1-monooxygenase activity Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0010956 gocheck_do_not_annotate GO:0034906 biolink:MolecularActivity N-isopropylaniline 1,2-dixoxygenase activity Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine. EC:1.14.12.-|UM-BBD_reactionID:r0721 go.json http://purl.obolibrary.org/obo/GO_0034906 GO:0044374 biolink:MolecularActivity sequence-specific DNA binding, bending The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. go.json DNA bending involving sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0044374 GO:0010957 biolink:BiologicalProcess negative regulation of vitamin D biosynthetic process Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json http://purl.obolibrary.org/obo/GO_0010957 GO:0009960 biolink:BiologicalProcess endosperm development The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo. go.json http://purl.obolibrary.org/obo/GO_0009960 GO:0010950 biolink:BiologicalProcess positive regulation of endopeptidase activity Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. go.json http://purl.obolibrary.org/obo/GO_0010950 gocheck_do_not_annotate GO:0009961 biolink:BiologicalProcess response to 1-aminocyclopropane-1-carboxylic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0009961 GO:0009962 biolink:BiologicalProcess regulation of flavonoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. go.json regulation of flavonoid anabolism|regulation of flavonoid biosynthesis|regulation of flavonoid formation|regulation of flavonoid synthesis http://purl.obolibrary.org/obo/GO_0009962 GO:0010951 biolink:BiologicalProcess negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. go.json http://purl.obolibrary.org/obo/GO_0010951 gocheck_do_not_annotate|goslim_chembl GO:0009963 biolink:BiologicalProcess positive regulation of flavonoid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. go.json activation of flavonoid biosynthetic process|positive regulation of flavonoid anabolism|positive regulation of flavonoid biosynthesis|positive regulation of flavonoid formation|positive regulation of flavonoid synthesis|stimulation of flavonoid biosynthetic process|up regulation of flavonoid biosynthetic process|up-regulation of flavonoid biosynthetic process|upregulation of flavonoid biosynthetic process http://purl.obolibrary.org/obo/GO_0009963 GO:0009964 biolink:BiologicalProcess negative regulation of flavonoid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. go.json down regulation of flavonoid biosynthetic process|down-regulation of flavonoid biosynthetic process|downregulation of flavonoid biosynthetic process|inhibition of flavonoid biosynthetic process|negative regulation of flavonoid anabolism|negative regulation of flavonoid biosynthesis|negative regulation of flavonoid formation|negative regulation of flavonoid synthesis http://purl.obolibrary.org/obo/GO_0009964 GO:0009965 biolink:BiologicalProcess leaf morphogenesis The process in which the anatomical structures of the leaf are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0009965 GO:0009966 biolink:BiologicalProcess regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. go.json regulation of signaling pathway|regulation of signalling pathway http://purl.obolibrary.org/obo/GO_0009966 GO:0009967 biolink:BiologicalProcess positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction. go.json activation of signal transduction|positive regulation of signaling pathway|positive regulation of signalling pathway|stimulation of signal transduction|up regulation of signal transduction|up-regulation of signal transduction|upregulation of signal transduction http://purl.obolibrary.org/obo/GO_0009967 GO:0009968 biolink:BiologicalProcess negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. go.json down regulation of signal transduction|down-regulation of signal transduction|downregulation of signal transduction|inhibition of signal transduction|negative regulation of signaling pathway|negative regulation of signalling pathway http://purl.obolibrary.org/obo/GO_0009968 GO:0009969 biolink:BiologicalProcess xyloglucan biosynthetic process The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. go.json xyloglucan anabolism|xyloglucan biosynthesis|xyloglucan formation|xyloglucan synthesis http://purl.obolibrary.org/obo/GO_0009969 GO:0019399 biolink:BiologicalProcess cyclohexanol oxidation The cyclohexanol metabolic process in which cyclohexanol is converted to adipate. MetaCyc:CYCLOHEXANOL-OXIDATION-PWY go.json http://purl.obolibrary.org/obo/GO_0019399 GO:0019397 biolink:BiologicalProcess gallate catabolic process via 2-pyrone-4,6-dicarboxylate The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate. MetaCyc:GALLATE-DEGRADATION-I-PWY go.json gallate breakdown via 2-pyrone-4,6-dicarboxylate|gallate degradation via 2-pyrone-4,6-dicarboxylate|gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate|gallic acid catabolism via 2-pyrone-4,6-dicarboxylate http://purl.obolibrary.org/obo/GO_0019397 GO:0019398 biolink:BiologicalProcess gallate catabolic process via gallate dioxygenase activity The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase. MetaCyc:GALLATE-DEGRADATION-II-PWY go.json gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate http://purl.obolibrary.org/obo/GO_0019398 GO:0019395 biolink:BiologicalProcess fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. MetaCyc:FAO-PWY go.json http://purl.obolibrary.org/obo/GO_0019395 GO:0019396 biolink:BiologicalProcess gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). UM-BBD_pathwayID:gal go.json gallate breakdown|gallate catabolism|gallate degradation|gallate metabolic process|gallate metabolism|gallic acid catabolic process|gallic acid catabolism|gallic acid metabolic process|gallic acid metabolism http://purl.obolibrary.org/obo/GO_0019396 GO:0019382 biolink:BiologicalProcess carbon tetrachloride catabolic process The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. go.json carbon tetrachloride breakdown|carbon tetrachloride catabolism|carbon tetrachloride degradation http://purl.obolibrary.org/obo/GO_0019382 GO:0019383 biolink:BiologicalProcess (+)-camphor catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone. MetaCyc:P601-PWY go.json (+)-camphor breakdown|(+)-camphor catabolism|(+)-camphor degradation http://purl.obolibrary.org/obo/GO_0019383 GO:0019380 biolink:BiologicalProcess 3-phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. MetaCyc:HCAMHPDEG-PWY|MetaCyc:P281-PWY go.json 3-phenylpropionate breakdown|3-phenylpropionate catabolism|3-phenylpropionate degradation http://purl.obolibrary.org/obo/GO_0019380 GO:0019381 biolink:BiologicalProcess atrazine catabolic process The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide. MetaCyc:P141-PWY go.json atrazine breakdown|atrazine catabolism|atrazine degradation http://purl.obolibrary.org/obo/GO_0019381 GO:0019379 biolink:BiologicalProcess sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8). MetaCyc:SO4ASSIM-PWY go.json sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin) http://purl.obolibrary.org/obo/GO_0019379 GO:0019377 biolink:BiologicalProcess glycolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). go.json glycolipid breakdown|glycolipid catabolism|glycolipid degradation http://purl.obolibrary.org/obo/GO_0019377 GO:0019378 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019378 GO:0019375 biolink:BiologicalProcess galactolipid biosynthetic process The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. go.json galactolipid anabolism|galactolipid biosynthesis|galactolipid formation|galactolipid synthesis http://purl.obolibrary.org/obo/GO_0019375 GO:0019376 biolink:BiologicalProcess galactolipid catabolic process The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. go.json galactolipid breakdown|galactolipid catabolism|galactolipid degradation http://purl.obolibrary.org/obo/GO_0019376 GO:0019373 biolink:BiologicalProcess epoxygenase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. go.json http://purl.obolibrary.org/obo/GO_0019373 GO:0019374 biolink:BiologicalProcess galactolipid metabolic process The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. go.json galactolipid metabolism http://purl.obolibrary.org/obo/GO_0019374 GO:0019393 biolink:BiologicalProcess glucarate biosynthetic process The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid. go.json glucarate anabolism|glucarate biosynthesis|glucarate formation|glucarate synthesis http://purl.obolibrary.org/obo/GO_0019393 GO:0019394 biolink:BiologicalProcess glucarate catabolic process The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid. MetaCyc:GLUCARDEG-PWY go.json glucarate breakdown|glucarate catabolism|glucarate degradation http://purl.obolibrary.org/obo/GO_0019394 GO:0019391 biolink:BiologicalProcess glucuronoside catabolic process The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. MetaCyc:GLUCUROCAT-PWY go.json glucuronide catabolic process|glucuronide catabolism|glucuronoside breakdown|glucuronoside catabolism|glucuronoside degradation http://purl.obolibrary.org/obo/GO_0019391 GO:0019392 biolink:BiologicalProcess glucarate metabolic process The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate. go.json glucarate metabolism http://purl.obolibrary.org/obo/GO_0019392 GO:0019390 biolink:BiologicalProcess glucuronoside biosynthetic process The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. go.json glucuronide biosynthesis|glucuronide biosynthetic process|glucuronoside anabolism|glucuronoside biosynthesis|glucuronoside formation|glucuronoside synthesis http://purl.obolibrary.org/obo/GO_0019390 GO:0019388 biolink:BiologicalProcess galactose catabolic process The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. MetaCyc:GALDEG-PWY go.json galactose breakdown|galactose catabolism|galactose degradation http://purl.obolibrary.org/obo/GO_0019388 GO:0019389 biolink:BiologicalProcess glucuronoside metabolic process The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate. go.json glucuronide metabolic process|glucuronide metabolism|glucuronoside metabolism http://purl.obolibrary.org/obo/GO_0019389 GO:0019386 biolink:BiologicalProcess methanogenesis, from carbon dioxide The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2). MetaCyc:METHANOGENESIS-PWY go.json methane biosynthesis from carbon dioxide|methane biosynthetic process from carbon dioxide http://purl.obolibrary.org/obo/GO_0019386 GO:0019387 biolink:BiologicalProcess methanogenesis, from methanol The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol. MetaCyc:METHFORM-PWY go.json methane biosynthesis from methanol|methane biosynthetic process from methanol http://purl.obolibrary.org/obo/GO_0019387 GO:0019384 biolink:BiologicalProcess caprolactam catabolic process The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid. MetaCyc:P621-PWY go.json caprolactam breakdown|caprolactam catabolism|caprolactam degradation http://purl.obolibrary.org/obo/GO_0019384 GO:0019385 biolink:BiologicalProcess methanogenesis, from acetate The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate. MetaCyc:METH-ACETATE-PWY go.json methane biosynthesis from acetate|methane biosynthetic process from acetate http://purl.obolibrary.org/obo/GO_0019385 GO:0019360 biolink:BiologicalProcess nicotinamide nucleotide biosynthetic process from niacinamide The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide. go.json nicotinamide nucleotide anabolism from niacinamide|nicotinamide nucleotide formation from niacinamide|nicotinamide nucleotide synthesis from niacinamide http://purl.obolibrary.org/obo/GO_0019360 GO:0019361 biolink:BiologicalProcess 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A. MetaCyc:P2-PWY go.json 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis http://purl.obolibrary.org/obo/GO_0019361 GO:0034998 biolink:CellularComponent oligosaccharyltransferase I complex An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes. go.json OSTCI http://purl.obolibrary.org/obo/GO_0034998 GO:0034999 biolink:CellularComponent oligosaccharyltransferase II complex An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes. go.json OSTCII http://purl.obolibrary.org/obo/GO_0034999 GO:0034990 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034990 GO:0034991 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034991 GO:0034992 biolink:CellularComponent microtubule organizing center attachment site A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope. go.json MAS|MTOC attachment site|microtubule organising centre attachment site http://purl.obolibrary.org/obo/GO_0034992 GO:0034993 biolink:CellularComponent meiotic nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. go.json LINC complex|LInker of Nucleoskeleton and Cytoskeleton complex|SUN-KASH complex http://purl.obolibrary.org/obo/GO_0034993 GO:0034994 biolink:BiologicalProcess microtubule organizing center attachment site organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches. go.json MAS organization|MTOC attachment site organization|microtubule organising centre attachment site organisation http://purl.obolibrary.org/obo/GO_0034994 GO:0034995 biolink:CellularComponent SC5b-7 complex A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly. go.json http://purl.obolibrary.org/obo/GO_0034995 GO:0019359 biolink:BiologicalProcess nicotinamide nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. go.json nicotinamide nucleotide anabolism|nicotinamide nucleotide biosynthesis|nicotinamide nucleotide formation|nicotinamide nucleotide synthesis http://purl.obolibrary.org/obo/GO_0019359 GO:0034996 biolink:CellularComponent RasGAP-Fyn-Lyn-Yes complex A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation. go.json p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated http://purl.obolibrary.org/obo/GO_0034996 GO:0034997 biolink:CellularComponent alphav-beta5 integrin-vitronectin complex A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin. go.json ITGAV-ITGB5-VTN complex http://purl.obolibrary.org/obo/GO_0034997 GO:0019357 biolink:BiologicalProcess nicotinate nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid). go.json nicotinate nucleotide anabolism|nicotinate nucleotide biosynthesis|nicotinate nucleotide formation|nicotinate nucleotide synthesis http://purl.obolibrary.org/obo/GO_0019357 GO:0019358 biolink:BiologicalProcess nicotinate nucleotide salvage The generation of nicotinate nucleotide without de novo synthesis. MetaCyc:PWY-5381|MetaCyc:PYRIDNUCSAL-PWY go.json nicotinate nucleotide biosynthesis, salvage pathway|nicotinate nucleotide biosynthetic process, salvage pathway http://purl.obolibrary.org/obo/GO_0019358 GO:0019355 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0019355 GO:0019356 biolink:BiologicalProcess nicotinate nucleotide biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan. go.json nicotinate nucleotide anabolism from tryptophan|nicotinate nucleotide formation from tryptophan|nicotinate nucleotide synthesis from tryptophan http://purl.obolibrary.org/obo/GO_0019356 GO:0019353 biolink:BiologicalProcess protoporphyrinogen IX biosynthetic process from glutamate The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate. go.json protoporphyrinogen IX anabolism from glutamate|protoporphyrinogen IX formation from glutamate|protoporphyrinogen IX synthesis from glutamate http://purl.obolibrary.org/obo/GO_0019353 GO:0019354 biolink:BiologicalProcess siroheme biosynthetic process The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. MetaCyc:PWY-5194 go.json sirohaem biosynthesis|sirohaem biosynthetic process|siroheme anabolism|siroheme biosynthesis|siroheme formation|siroheme synthase activity|siroheme synthesis http://purl.obolibrary.org/obo/GO_0019354 GO:0019351 biolink:BiologicalProcess dethiobiotin biosynthetic process The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms. go.json desthiobiotin biosynthesis|desthiobiotin biosynthetic process|dethiobiotin anabolism|dethiobiotin biosynthesis|dethiobiotin formation|dethiobiotin synthesis http://purl.obolibrary.org/obo/GO_0019351 GO:0019352 biolink:BiologicalProcess protoporphyrinogen IX biosynthetic process from glycine The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine. go.json protoporphyrinogen IX anabolism from glycine|protoporphyrinogen IX formation from glycine|protoporphyrinogen IX synthesis from glycine http://purl.obolibrary.org/obo/GO_0019352 GO:0019371 biolink:BiologicalProcess cyclooxygenase pathway The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. go.json http://purl.obolibrary.org/obo/GO_0019371 GO:0019372 biolink:BiologicalProcess lipoxygenase pathway The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. go.json http://purl.obolibrary.org/obo/GO_0019372 GO:0019370 biolink:BiologicalProcess leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. Wikipedia:Leukotriene#Leukotriene_synthesis go.json leukotriene anabolism|leukotriene biosynthesis|leukotriene formation|leukotriene synthesis http://purl.obolibrary.org/obo/GO_0019370 GO:0034987 biolink:MolecularActivity immunoglobulin receptor binding Binding to one or more specific sites on an immunoglobulin receptor molecule. go.json Fc receptor binding http://purl.obolibrary.org/obo/GO_0034987 GO:0034988 biolink:MolecularActivity Fc-gamma receptor I complex binding Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. go.json http://purl.obolibrary.org/obo/GO_0034988 GO:0034989 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034989 GO:0034980 biolink:CellularComponent FHL2-CREB complex A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation. go.json http://purl.obolibrary.org/obo/GO_0034980 GO:0034981 biolink:CellularComponent FHL3-CREB complex A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation. go.json http://purl.obolibrary.org/obo/GO_0034981 GO:0034982 biolink:BiologicalProcess mitochondrial protein processing The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. go.json mitochondrial protein modification http://purl.obolibrary.org/obo/GO_0034982 GO:0034983 biolink:BiologicalProcess peptidyl-lysine deacetylation The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. go.json protein lysine acetylation http://purl.obolibrary.org/obo/GO_0034983 gocheck_do_not_annotate GO:0034984 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034984 GO:0034985 biolink:CellularComponent Ecsit-NDUFAF1 complex Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed. go.json http://purl.obolibrary.org/obo/GO_0034985 GO:0034986 biolink:MolecularActivity iron chaperone activity Directly binding to and delivering iron ions to a target protein. go.json http://purl.obolibrary.org/obo/GO_0034986 GO:0019368 biolink:BiologicalProcess fatty acid elongation, unsaturated fatty acid Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced. MetaCyc:PWY0-862 go.json http://purl.obolibrary.org/obo/GO_0019368 GO:0019369 biolink:BiologicalProcess arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. Wikipedia:Arachidonic_acid go.json arachidonic acid metabolism http://purl.obolibrary.org/obo/GO_0019369 GO:0019367 biolink:BiologicalProcess fatty acid elongation, saturated fatty acid Elongation of a saturated fatty acid chain. MetaCyc:FASYN-ELONG-PWY go.json http://purl.obolibrary.org/obo/GO_0019367 GO:0019364 biolink:BiologicalProcess pyridine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. go.json pyridine nucleotide breakdown|pyridine nucleotide catabolism|pyridine nucleotide degradation http://purl.obolibrary.org/obo/GO_0019364 GO:0019365 biolink:BiologicalProcess pyridine nucleotide salvage Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis. go.json pyridine nucleotide cycling http://purl.obolibrary.org/obo/GO_0019365 GO:0019362 biolink:BiologicalProcess pyridine nucleotide metabolic process The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. go.json pyridine nucleotide metabolism http://purl.obolibrary.org/obo/GO_0019362 GO:0019363 biolink:BiologicalProcess pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. MetaCyc:PYRIDNUCSYN-PWY go.json pyridine nucleotide anabolism|pyridine nucleotide biosynthesis|pyridine nucleotide formation|pyridine nucleotide synthesis http://purl.obolibrary.org/obo/GO_0019363 GO:0103041 biolink:MolecularActivity thiosulfate-thioredoxin sulfurtransferase activity Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin. MetaCyc:RXN0-6385 go.json http://purl.obolibrary.org/obo/GO_0103041 GO:0103042 biolink:MolecularActivity 4-hydroxy-L-threonine aldolase activity Catalysis of the reaction: 4-hydroxy-L-threonine = glycolaldehyde + glycine. MetaCyc:RXN0-6563|RHEA:28779 go.json http://purl.obolibrary.org/obo/GO_0103042 GO:0103040 biolink:MolecularActivity aldose sugar dehydrogenase activity Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor. MetaCyc:RXN0-6371 go.json http://purl.obolibrary.org/obo/GO_0103040 GO:0103045 biolink:MolecularActivity methione N-acyltransferase activity Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+. EC:2.3.1.1|MetaCyc:RXN0-6948|RHEA:44144 go.json http://purl.obolibrary.org/obo/GO_0103045 GO:0103046 biolink:MolecularActivity alanylglutamate dipeptidase activity Catalysis of the reaction: L-alanyl-L-glutamate + H2O = L-alanine + L-glutamate. EC:3.4.13.18|MetaCyc:RXN0-6981 go.json http://purl.obolibrary.org/obo/GO_0103046 GO:0103043 biolink:MolecularActivity 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = H+ + alpha-D-ribose 1,5-bisphosphate. EC:3.1.4.55|MetaCyc:RXN0-6710|RHEA:34795 go.json http://purl.obolibrary.org/obo/GO_0103043 GO:0103044 biolink:MolecularActivity ribosomal protein S6 glutamate-glutamate ligase activity Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate. MetaCyc:RXN0-6726 go.json http://purl.obolibrary.org/obo/GO_0103044 GO:0103047 biolink:MolecularActivity methyl beta-D-glucoside 6-phosphate glucohydrolase activity Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol. EC:3.2.1.86|MetaCyc:RXN0-6994 go.json http://purl.obolibrary.org/obo/GO_0103047 GO:0103048 biolink:MolecularActivity obsolete tRNA m2A37 methyltransferase activity OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA. go.json True http://purl.obolibrary.org/obo/GO_0103048 GO:0103052 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103052 GO:0103053 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103053 GO:0103050 biolink:MolecularActivity obsolete isobutyraldehyde reductase activity OBSOLETE. Catalysis of the reaction: isobutanol + NADP = isobutyraldehyde + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0103050 GO:0103051 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103051 GO:0103056 biolink:MolecularActivity gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate = gibberellin A44 diacid + carbon dioxide + succinate. MetaCyc:RXN1F-167|RHEA:60800 go.json http://purl.obolibrary.org/obo/GO_0103056 GO:0103057 biolink:MolecularActivity gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate = H+ + gibberellin A20 + 2 carbon dioxide + succinate. MetaCyc:RXN1F-169 go.json http://purl.obolibrary.org/obo/GO_0103057 GO:0103054 biolink:MolecularActivity gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming) Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate = gibberellin A15 + carbon dioxide + succinate. MetaCyc:RXN1F-162|RHEA:60776 go.json http://purl.obolibrary.org/obo/GO_0103054 GO:0103055 biolink:MolecularActivity gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 = gibberellin A24 + succinate + carbon dioxide + H2O. MetaCyc:RXN1F-163|RHEA:60780 go.json http://purl.obolibrary.org/obo/GO_0103055 GO:0103058 biolink:MolecularActivity kaempferol 3-glucoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose = kaempferol-3-glucoside-7-rhamnoside + UDP. MetaCyc:RXN1F-443 go.json http://purl.obolibrary.org/obo/GO_0103058 GO:0103059 biolink:MolecularActivity UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose = H+ + kaempferol-3-rhamnoside + UDP(3-). MetaCyc:RXN1F-474|RHEA:61164 go.json http://purl.obolibrary.org/obo/GO_0103059 GO:0103060 biolink:MolecularActivity kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose = kaempferol-3-rhamnoside-7-rhamnoside + UDP. MetaCyc:RXN1F-475 go.json http://purl.obolibrary.org/obo/GO_0103060 GO:0103063 biolink:MolecularActivity trans-keto-C61-meroacyl-AMP ligase activity Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] = diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]. MetaCyc:RXN1G-4143 go.json http://purl.obolibrary.org/obo/GO_0103063 GO:0103064 biolink:MolecularActivity inositol phosphorylceramide mannosyltransferase activity Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+. EC:2.4.1.370|MetaCyc:RXN3O-663|RHEA:64596|https://github.com/geneontology/go-ontology/issues/21803 go.json http://purl.obolibrary.org/obo/GO_0103064 GO:0103061 biolink:MolecularActivity trans-methoxy-C60-meroacyl-AMP ligase activity Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] = diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]. MetaCyc:RXN1G-4141 go.json http://purl.obolibrary.org/obo/GO_0103061 GO:0103062 biolink:MolecularActivity cis-keto-C60-meroacyl-AMP ligase activity Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] = diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]. MetaCyc:RXN1G-4142 go.json http://purl.obolibrary.org/obo/GO_0103062 GO:0103067 biolink:MolecularActivity 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H. EC:1.1.1.170|MetaCyc:RXN66-23|RHEA:33447 go.json http://purl.obolibrary.org/obo/GO_0103067 GO:0103068 biolink:MolecularActivity leukotriene C4 gamma-glutamyl transferase activity Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. EC:2.3.2.2|MetaCyc:RXN66-336 go.json http://purl.obolibrary.org/obo/GO_0103068 GO:0103066 biolink:MolecularActivity 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H. EC:1.1.1.170|MetaCyc:RXN66-18 go.json http://purl.obolibrary.org/obo/GO_0103066 GO:0103069 biolink:MolecularActivity 17-hydroxyprogesterone 21-hydroxylase activity Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. MetaCyc:RXN66-356|RHEA:50308 go.json http://purl.obolibrary.org/obo/GO_0103069 GO:0103071 biolink:MolecularActivity obsolete 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity OBSOLETE. Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA = formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde. go.json True http://purl.obolibrary.org/obo/GO_0103071 GO:0103074 biolink:MolecularActivity glucose-6-phosphate 3-dehydrogenase activity Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate. EC:1.1.1.361|MetaCyc:RXN8J2-136|RHEA:37547 go.json http://purl.obolibrary.org/obo/GO_0103074 GO:0103075 biolink:MolecularActivity indole-3-pyruvate monooxygenase activity Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ = indole-3-acetate + carbon dioxide + NADP + H2O. EC:1.14.13.168|MetaCyc:RXNDQC-2|RHEA:34331 go.json http://purl.obolibrary.org/obo/GO_0103075 GO:0103072 biolink:MolecularActivity straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde. MetaCyc:RXN66-475 go.json http://purl.obolibrary.org/obo/GO_0103072 GO:0103073 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103073 GO:0103078 biolink:MolecularActivity quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose = quercetin-3-rhamnoside-7-rhamnoside + UDP. MetaCyc:RXNQT-4162|RHEA:61184 go.json http://purl.obolibrary.org/obo/GO_0103078 GO:0103079 biolink:MolecularActivity 2-(3'-methylthio)propylmalate synthase activity Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = H+ + 2-(3-methylthiopropyl)malate + coenzyme A. MetaCyc:RXNQT-4163|RHEA:25605 go.json http://purl.obolibrary.org/obo/GO_0103079 GO:0103077 biolink:MolecularActivity quercetin 3-glucoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose = quercetin-3-O-glucoside-7-O-rhamnoside + UDP. MetaCyc:RXNQT-4161|RHEA:61188 go.json http://purl.obolibrary.org/obo/GO_0103077 GO:0103081 biolink:MolecularActivity obsolete methylthiopropylmalate dehydrogenase activity OBSOLETE. Catalysis of the reaction: 3-(3'-methylthio)propylmalate = H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide. go.json True http://purl.obolibrary.org/obo/GO_0103081 GO:0103082 biolink:MolecularActivity 2-(4'-methylthio)butylmalate synthase activity Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O = H+ + 2-(4'-methylthio)butylmalate + coenzyme A. MetaCyc:RXNQT-4166 go.json http://purl.obolibrary.org/obo/GO_0103082 GO:0103080 biolink:MolecularActivity methylthiopropylmalate isomerase activity Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) = 3-(3'-methylthio)propylmalate. MetaCyc:RXNQT-4164|RHEA:50644 go.json http://purl.obolibrary.org/obo/GO_0103080 GO:0103001 biolink:MolecularActivity dimethylsulfoxide oxygenase activity Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ = sulfonyldimethane + H2O + NADP. MetaCyc:RXN-9767|RHEA:57956 go.json http://purl.obolibrary.org/obo/GO_0103001 GO:0103002 biolink:MolecularActivity 16-hydroxypalmitate dehydrogenase activity Catalysis of the reaction: 16-hydroxypalmitate + NADP = H+ + 16-oxo-palmitate + NADPH. MetaCyc:RXN-9802 go.json http://purl.obolibrary.org/obo/GO_0103002 GO:0103000 biolink:MolecularActivity UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene = 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+. MetaCyc:RXN-9748 go.json http://purl.obolibrary.org/obo/GO_0103000 GO:0103005 biolink:MolecularActivity 9,10-epoxystearate hydrolase activity Catalysis of the reaction: 9,10-epoxystearate + H2O = (9R,10S)-dihydroxystearate. MetaCyc:RXN-9806 go.json http://purl.obolibrary.org/obo/GO_0103005 GO:0103006 biolink:MolecularActivity 9,10-dihydroxystearate hydroxylase activity Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP. MetaCyc:RXN-9807 go.json http://purl.obolibrary.org/obo/GO_0103006 GO:0103003 biolink:MolecularActivity oleate peroxygenase activity Catalysis of the reaction: oleate + a lipid hydroperoxide = 9,10-epoxystearate + a lipid alcohol. MetaCyc:RXN-9804 go.json http://purl.obolibrary.org/obo/GO_0103003 GO:0103004 biolink:MolecularActivity 9,10-epoxystearate hydroxylase activity Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH = 9,10-epoxy-18-hydroxystearate + H2O + NADP. MetaCyc:RXN-9805 go.json http://purl.obolibrary.org/obo/GO_0103004 GO:0103009 biolink:MolecularActivity 3-chlorotoluene monooxygenase activity Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 = 3-chlorobenzyl alcohol + NAD + H2O. MetaCyc:RXN-9908 go.json http://purl.obolibrary.org/obo/GO_0103009 GO:0103007 biolink:MolecularActivity indole-3-acetate carboxyl methyltransferase activity Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine. EC:2.1.1.278|MetaCyc:RXN-9825|RHEA:36131 go.json http://purl.obolibrary.org/obo/GO_0103007 GO:0103008 biolink:MolecularActivity 4-chloro-2-methylphenoxyacetate oxygenase activity Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide. MetaCyc:RXN-9864 go.json http://purl.obolibrary.org/obo/GO_0103008 GO:0103012 biolink:MolecularActivity ferredoxin-thioredoxin reductase activity Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide. EC:1.8.7.2|MetaCyc:RXN-9944|RHEA:42336 go.json ferredoxin:thioredoxin reductase activity http://purl.obolibrary.org/obo/GO_0103012 GO:0103010 biolink:MolecularActivity gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming) Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide. MetaCyc:RXN-991 go.json http://purl.obolibrary.org/obo/GO_0103010 GO:0103011 biolink:MolecularActivity mannosylfructose-phosphate synthase activity Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate = mannosylfructose-phosphate + GDP. EC:2.4.1.246|MetaCyc:RXN-9935|RHEA:26039 go.json http://purl.obolibrary.org/obo/GO_0103011 GO:0103016 biolink:MolecularActivity tRNA-specific 2-thiouridylase activity Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine. MetaCyc:RXN0-2023 go.json http://purl.obolibrary.org/obo/GO_0103016 GO:0103014 biolink:MolecularActivity obsolete beta-keto ester reductase activity OBSOLETE. Catalysis of the reaction: ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP = ethyl-2-methylacetoacetate + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0103014 GO:0103015 biolink:MolecularActivity 4-amino-4-deoxy-L-arabinose transferase activity Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate. EC:2.4.2.43|MetaCyc:RXN0-2001|RHEA:35371 go.json http://purl.obolibrary.org/obo/GO_0103015 GO:0103019 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103019 GO:0103020 biolink:MolecularActivity 1-deoxy-D-xylulose kinase activity Catalysis of the reaction: 1-deoxy-D-xylulose + ATP = H+ + 1-deoxy-D-xylulose 5-phosphate + ADP. MetaCyc:RXN0-382|RHEA:27990 go.json http://purl.obolibrary.org/obo/GO_0103020 GO:0103023 biolink:MolecularActivity ITPase activity Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate. EC:3.6.1.73|MetaCyc:RXN0-5073|RHEA:28330 go.json http://purl.obolibrary.org/obo/GO_0103023 GO:0103024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103024 GO:0103027 biolink:MolecularActivity FMN phosphatase activity Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate. MetaCyc:RXN0-5187 go.json http://purl.obolibrary.org/obo/GO_0103027 GO:0103028 biolink:MolecularActivity murein hydrolase activity Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide. MetaCyc:RXN0-5190 go.json http://purl.obolibrary.org/obo/GO_0103028 GO:0103025 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103025 GO:0103026 biolink:MolecularActivity fructose-1-phosphatase activity Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O = beta-D-fructofuranose + hydrogenphosphate. MetaCyc:RXN0-5186|RHEA:35603 go.json http://purl.obolibrary.org/obo/GO_0103026 GO:0103030 biolink:MolecularActivity obsolete ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity OBSOLETE. Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD. go.json True http://purl.obolibrary.org/obo/GO_0103030 GO:0103031 biolink:MolecularActivity L-Ala-D/L-Glu epimerase activity Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate. MetaCyc:RXN0-5228|RHEA:28394 go.json http://purl.obolibrary.org/obo/GO_0103031 GO:0103035 biolink:MolecularActivity NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP. MetaCyc:RXN0-5387 go.json http://purl.obolibrary.org/obo/GO_0103035 GO:0103032 biolink:MolecularActivity obsolete tartronate semialdehyde reductase activity OBSOLETE. Catalysis of the reaction: D-glycerate + NAD = H+ + 2-hydroxy-3-oxopropanoate + NADH. go.json True http://purl.obolibrary.org/obo/GO_0103032 GO:0103033 biolink:MolecularActivity beta-galactosidase activity (lactose isomerization) Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose. MetaCyc:RXN0-5363 go.json http://purl.obolibrary.org/obo/GO_0103033 GO:0103039 biolink:MolecularActivity protein methylthiotransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor. EC:2.8.4.4|MetaCyc:RXN0-6366|RHEA:37087 go.json http://purl.obolibrary.org/obo/GO_0103039 GO:0103036 biolink:MolecularActivity NADH:menaquinone oxidoreductase activity Catalysis of the reaction: 5 H+ + NADH + a menaquinone = 4 H+ + NAD + a menaquinol. MetaCyc:RXN0-5388 go.json http://purl.obolibrary.org/obo/GO_0103036 GO:0103037 biolink:MolecularActivity L-glyceraldehyde 3-phosphate reductase activity Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH. MetaCyc:RXN0-5410 go.json http://purl.obolibrary.org/obo/GO_0103037 GO:0010929 biolink:BiologicalProcess positive regulation of auxin mediated signaling pathway Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. go.json positive regulation of auxin mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010929 GO:0044261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044261 GO:0044262 biolink:BiologicalProcess obsolete cellular carbohydrate metabolic process OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. go.json cellular carbohydrate metabolism|main pathways of carbohydrate metabolic process|main pathways of carbohydrate metabolism True http://purl.obolibrary.org/obo/GO_0044262 GO:0010927 biolink:BiologicalProcess cellular component assembly involved in morphogenesis The cellular component assembly that is part of the initial shaping of the component during its developmental progression. go.json http://purl.obolibrary.org/obo/GO_0010927 GO:0044260 biolink:BiologicalProcess obsolete cellular macromolecule metabolic process OBSOLETE. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. go.json cellular biopolymer metabolic process|cellular macromolecule metabolism True http://purl.obolibrary.org/obo/GO_0044260 GO:0010928 biolink:BiologicalProcess regulation of auxin mediated signaling pathway Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. go.json regulation of auxin mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010928 GO:0044269 biolink:BiologicalProcess glycerol ether catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. go.json glycerol ether breakdown|glycerol ether catabolism|glycerol ether degradation http://purl.obolibrary.org/obo/GO_0044269 GO:0010921 biolink:BiologicalProcess regulation of phosphatase activity Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. go.json http://purl.obolibrary.org/obo/GO_0010921 gocheck_do_not_annotate GO:0010922 biolink:BiologicalProcess positive regulation of phosphatase activity Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. go.json http://purl.obolibrary.org/obo/GO_0010922 gocheck_do_not_annotate GO:0044267 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044267 GO:0044268 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044268 GO:0010920 biolink:BiologicalProcess negative regulation of inositol phosphate biosynthetic process Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. go.json negative regulation of inositol phosphate biosynthesis http://purl.obolibrary.org/obo/GO_0010920 GO:0044265 biolink:BiologicalProcess obsolete cellular macromolecule catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. go.json cellular biopolymer catabolic process|cellular macromolecule breakdown|cellular macromolecule catabolism|cellular macromolecule degradation True http://purl.obolibrary.org/obo/GO_0044265 GO:0010925 biolink:BiologicalProcess positive regulation of inositol-polyphosphate 5-phosphatase activity Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0010925 gocheck_do_not_annotate GO:0010926 biolink:BiologicalProcess obsolete anatomical structure formation OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. go.json anatomical structure formation True http://purl.obolibrary.org/obo/GO_0010926 GO:0044266 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044266 GO:0010923 biolink:BiologicalProcess negative regulation of phosphatase activity Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. go.json http://purl.obolibrary.org/obo/GO_0010923 gocheck_do_not_annotate GO:0044263 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044263 GO:0010924 biolink:BiologicalProcess regulation of inositol-polyphosphate 5-phosphatase activity Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0010924 gocheck_do_not_annotate GO:0044264 biolink:BiologicalProcess obsolete cellular polysaccharide metabolic process OBSOLETE. The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. go.json cellular glycan metabolic process|cellular glycan metabolism|cellular polysaccharide metabolism True http://purl.obolibrary.org/obo/GO_0044264 GO:0009930 biolink:CellularComponent longitudinal side of cell surface The side of the cell parallel to the zygotic axis. go.json http://purl.obolibrary.org/obo/GO_0009930 GO:0009931 biolink:MolecularActivity calcium-dependent protein serine/threonine kinase activity Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. go.json http://purl.obolibrary.org/obo/GO_0009931 GO:0009932 biolink:BiologicalProcess cell tip growth Growth that occurs specifically at the tip of a cell. go.json http://purl.obolibrary.org/obo/GO_0009932 GO:0009933 biolink:BiologicalProcess meristem structural organization Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. go.json meristem organisation|meristem organization http://purl.obolibrary.org/obo/GO_0009933 GO:0009934 biolink:BiologicalProcess regulation of meristem structural organization Any process that modulates the frequency, rate or extent of meristem organization. go.json regulation of meristem organisation|regulation of meristem organization http://purl.obolibrary.org/obo/GO_0009934 GO:0009935 biolink:BiologicalProcess obsolete nutrient import OBSOLETE. The directed movement of nutrients into a cell or organelle. go.json nutrient import|nutrient uptake True http://purl.obolibrary.org/obo/GO_0009935 GO:0009936 biolink:MolecularActivity obsolete expansin OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa. go.json expansin True http://purl.obolibrary.org/obo/GO_0009936 GO:0009937 biolink:BiologicalProcess regulation of gibberellic acid mediated signaling pathway Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling. go.json regulation of gibberellic acid mediated signalling http://purl.obolibrary.org/obo/GO_0009937 GO:0009938 biolink:BiologicalProcess negative regulation of gibberellic acid mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity. go.json down regulation of gibberellic acid mediated signaling|down-regulation of gibberellic acid mediated signaling|downregulation of gibberellic acid mediated signaling|inhibition of gibberellic acid mediated signaling|negative regulation of gibberellic acid mediated signalling http://purl.obolibrary.org/obo/GO_0009938 GO:0009939 biolink:BiologicalProcess positive regulation of gibberellic acid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity. go.json activation of gibberellic acid mediated signaling|positive regulation of gibberellic acid mediated signalling|stimulation of gibberellic acid mediated signaling|up regulation of gibberellic acid mediated signaling|up-regulation of gibberellic acid mediated signaling|upregulation of gibberellic acid mediated signaling http://purl.obolibrary.org/obo/GO_0009939 GO:0044272 biolink:BiologicalProcess sulfur compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. go.json sulfur biosynthesis|sulfur biosynthetic process|sulfur compound anabolism|sulfur compound biosynthesis|sulfur compound formation|sulfur compound synthesis http://purl.obolibrary.org/obo/GO_0044272 GO:0044273 biolink:BiologicalProcess sulfur compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. go.json sulfur catabolic process|sulfur catabolism|sulfur compound breakdown|sulfur compound catabolism|sulfur compound degradation http://purl.obolibrary.org/obo/GO_0044273 GO:0044270 biolink:BiologicalProcess cellular nitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. go.json nitrogen compound breakdown|nitrogen compound catabolism|nitrogen compound degradation http://purl.obolibrary.org/obo/GO_0044270 GO:0010938 biolink:BiologicalProcess cytoplasmic microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. go.json http://purl.obolibrary.org/obo/GO_0010938 GO:0044271 biolink:BiologicalProcess cellular nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. go.json nitrogen compound anabolism|nitrogen compound biosynthesis|nitrogen compound formation|nitrogen compound synthesis http://purl.obolibrary.org/obo/GO_0044271 GO:0010939 biolink:BiologicalProcess obsolete regulation of necrotic cell death OBSOLETE. Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. go.json True http://purl.obolibrary.org/obo/GO_0010939 GO:0010932 biolink:BiologicalProcess regulation of macrophage tolerance induction Any process that modulates the frequency, rate, or extent of macrophage tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0010932 GO:0010933 biolink:BiologicalProcess positive regulation of macrophage tolerance induction Any process that increases the frequency, rate, or extent of B cell tolerance induction. go.json http://purl.obolibrary.org/obo/GO_0010933 GO:0044278 biolink:BiologicalProcess disruption of cell wall in another organism The disruption of the cell wall of another organism, leading to damage or temporary subversion of the cell wall. go.json cell wall disruption in another organism|cell wall disruption in other organism http://purl.obolibrary.org/obo/GO_0044278 GO:0010930 biolink:BiologicalProcess negative regulation of auxin mediated signaling pathway Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. go.json negative regulation of auxin mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010930 GO:0044279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044279 GO:0010931 biolink:BiologicalProcess macrophage tolerance induction A process involving any mechanism for tolerance induction in macrophages. go.json http://purl.obolibrary.org/obo/GO_0010931 GO:0010936 biolink:BiologicalProcess negative regulation of macrophage cytokine production Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0010936 GO:0044276 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044276 GO:0044277 biolink:BiologicalProcess cell wall disassembly A process that results in the breakdown of the cell wall. go.json cellular cell wall disassembly http://purl.obolibrary.org/obo/GO_0044277 GO:0010937 biolink:BiologicalProcess regulation of cytoplasmic microtubule depolymerization Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. go.json http://purl.obolibrary.org/obo/GO_0010937 GO:0010934 biolink:BiologicalProcess macrophage cytokine production The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0010934 gocheck_do_not_annotate GO:0044274 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044274 GO:0010935 biolink:BiologicalProcess regulation of macrophage cytokine production Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0010935 GO:0044275 biolink:BiologicalProcess obsolete cellular carbohydrate catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. go.json cellular carbohydrate breakdown|cellular carbohydrate catabolism|cellular carbohydrate degradation True http://purl.obolibrary.org/obo/GO_0044275 GO:0009940 biolink:MolecularActivity amino-terminal vacuolar sorting propeptide binding Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles. go.json http://purl.obolibrary.org/obo/GO_0009940 GO:0009941 biolink:CellularComponent chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0009941 GO:0009942 biolink:BiologicalProcess longitudinal axis specification The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root. go.json apical-basal pattern specification|longitudinal axis determination http://purl.obolibrary.org/obo/GO_0009942 GO:0009943 biolink:BiologicalProcess adaxial/abaxial axis specification The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. go.json adaxial/abaxial determination http://purl.obolibrary.org/obo/GO_0009943 GO:0009944 biolink:BiologicalProcess polarity specification of adaxial/abaxial axis The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. go.json http://purl.obolibrary.org/obo/GO_0009944 GO:0009945 biolink:BiologicalProcess radial axis specification The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point. go.json http://purl.obolibrary.org/obo/GO_0009945 GO:0009946 biolink:BiologicalProcess proximal/distal axis specification The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). go.json proximal/distal axis determination|proximodistal axis specification http://purl.obolibrary.org/obo/GO_0009946 GO:0009947 biolink:BiologicalProcess centrolateral axis specification The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf. go.json centrolateral axis determination|mediolateral axis specification http://purl.obolibrary.org/obo/GO_0009947 GO:0009948 biolink:BiologicalProcess anterior/posterior axis specification The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. go.json anterior/posterior axis determination http://purl.obolibrary.org/obo/GO_0009948 GO:0009949 biolink:BiologicalProcess polarity specification of anterior/posterior axis Any process resulting in the establishment of polarity along the anterior/posterior axis. go.json http://purl.obolibrary.org/obo/GO_0009949 GO:0009918 biolink:MolecularActivity sterol delta7 reductase activity Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. MetaCyc:RXN-707 go.json sterol delta-7 reductase activity http://purl.obolibrary.org/obo/GO_0009918 GO:0010907 biolink:BiologicalProcess positive regulation of glucose metabolic process Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. go.json positive regulation of glucose metabolism http://purl.obolibrary.org/obo/GO_0010907 GO:0044283 biolink:BiologicalProcess small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. go.json small molecule biosynthesis http://purl.obolibrary.org/obo/GO_0044283 prokaryote_subset GO:0009919 biolink:BiologicalProcess obsolete cytokinesis (sensu Viridiplantae) OBSOLETE. The division of a cell into two daughter cells with cell walls. go.json cytokinesis (sensu Viridiplantae) True http://purl.obolibrary.org/obo/GO_0009919 GO:0044284 biolink:CellularComponent mitochondrial crista junction A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane. go.json crista junction|cristae junction http://purl.obolibrary.org/obo/GO_0044284 GO:0010908 biolink:BiologicalProcess regulation of heparan sulfate proteoglycan biosynthetic process Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues. go.json http://purl.obolibrary.org/obo/GO_0010908 GO:0044281 biolink:BiologicalProcess small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. go.json small molecule metabolism http://purl.obolibrary.org/obo/GO_0044281 goslim_chembl|goslim_flybase_ribbon|goslim_metagenomics GO:0010905 biolink:BiologicalProcess negative regulation of UDP-glucose catabolic process Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. go.json negative regulation of UDP-glucose catabolism http://purl.obolibrary.org/obo/GO_0010905 GO:0010906 biolink:BiologicalProcess regulation of glucose metabolic process Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. go.json regulation of glucose metabolism http://purl.obolibrary.org/obo/GO_0010906 GO:0044282 biolink:BiologicalProcess small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. go.json small molecule catabolism http://purl.obolibrary.org/obo/GO_0044282 GO:0044280 biolink:CellularComponent subplasmalemmal coating Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier. NIF_Subcellular:sao1938587839 go.json http://purl.obolibrary.org/obo/GO_0044280 GO:0010909 biolink:BiologicalProcess positive regulation of heparan sulfate proteoglycan biosynthetic process Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues. go.json http://purl.obolibrary.org/obo/GO_0010909 GO:0010900 biolink:BiologicalProcess negative regulation of phosphatidylcholine catabolic process Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. go.json http://purl.obolibrary.org/obo/GO_0010900 GO:0044289 biolink:CellularComponent mitochondrial inner-outer membrane contact site Sites of close apposition of the inner and outer mitochondrial membrane. go.json bridge contact site|contact site http://purl.obolibrary.org/obo/GO_0044289 GO:0044287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044287 GO:0010903 biolink:BiologicalProcess negative regulation of very-low-density lipoprotein particle remodeling Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. go.json negative regulation of VLDL remodeling|negative regulation of VLDL remodelling|negative regulation of very-low-density lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0010903 GO:0044288 biolink:CellularComponent puncta adhaerentia A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells. NIF_Subcellular:sao257629430 go.json http://purl.obolibrary.org/obo/GO_0044288 GO:0010904 biolink:BiologicalProcess regulation of UDP-glucose catabolic process Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. go.json regulation of UDP-glucose catabolism http://purl.obolibrary.org/obo/GO_0010904 GO:0010901 biolink:BiologicalProcess regulation of very-low-density lipoprotein particle remodeling Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. go.json regulation of VLDL remodeling|regulation of VLDL remodelling|regulation of very-low-density lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0010901 GO:0044285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0044285 GO:0010902 biolink:BiologicalProcess positive regulation of very-low-density lipoprotein particle remodeling Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. go.json positive regulation of VLDL remodeling|positive regulation of VLDL remodelling|positive regulation of very-low-density lipoprotein particle remodelling http://purl.obolibrary.org/obo/GO_0010902 GO:0044286 biolink:CellularComponent peg and socket contact A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells. NIF_Subcellular:sao1943947957 go.json ball and socket contact http://purl.obolibrary.org/obo/GO_0044286 GO:0009910 biolink:BiologicalProcess negative regulation of flower development Any process that stops, prevents, or reduces the frequency, rate or extent of flower development. go.json down regulation of flower development|down-regulation of flower development|downregulation of flower development|inhibition of flower development http://purl.obolibrary.org/obo/GO_0009910 GO:0009911 biolink:BiologicalProcess positive regulation of flower development Any process that activates or increases the frequency, rate or extent of flower development. go.json activation of flower development|stimulation of flower development|up regulation of flower development|up-regulation of flower development|upregulation of flower development http://purl.obolibrary.org/obo/GO_0009911 GO:0009912 biolink:BiologicalProcess auditory receptor cell fate commitment The process in which the cellular identity of auditory hair cells is acquired and determined. go.json auditory hair cell fate commitment http://purl.obolibrary.org/obo/GO_0009912 GO:0009913 biolink:BiologicalProcess epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. go.json hypodermal cell differentiation http://purl.obolibrary.org/obo/GO_0009913 GO:0009914 biolink:BiologicalProcess hormone transport The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0009914 goslim_pir GO:0009915 biolink:BiologicalProcess phloem sucrose loading The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink. go.json http://purl.obolibrary.org/obo/GO_0009915 GO:0009916 biolink:MolecularActivity alternative oxidase activity Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product. go.json http://purl.obolibrary.org/obo/GO_0009916 GO:0009917 biolink:MolecularActivity sterol 5-alpha reductase activity Catalysis of the removal of a C-5 double bond in the B ring of a sterol. go.json http://purl.obolibrary.org/obo/GO_0009917 GO:0044294 biolink:CellularComponent dendritic growth cone The migrating motile tip of a growing nerve cell dendrite. NIF_Subcellular:sao1594955670 go.json dendrite growth cone http://purl.obolibrary.org/obo/GO_0044294 GO:0010918 biolink:BiologicalProcess positive regulation of mitochondrial membrane potential Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json elevation of mitochondrial membrane potential http://purl.obolibrary.org/obo/GO_0010918 GO:0009929 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009929 GO:0010919 biolink:BiologicalProcess regulation of inositol phosphate biosynthetic process Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. go.json regulation of inositol phosphate biosynthesis http://purl.obolibrary.org/obo/GO_0010919 GO:0044295 biolink:CellularComponent axonal growth cone The migrating motile tip of a growing nerve cell axon. NIF_Subcellular:sao1594955670|NIF_Subcellular:sao203987954 go.json axon growth cone http://purl.obolibrary.org/obo/GO_0044295 GO:0044292 biolink:CellularComponent dendrite terminus A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. NIF_Subcellular:sao28175134 go.json dendrite terminal|dendrite terminal specialization|terminal specialization|terminal specialization of a dendrite http://purl.obolibrary.org/obo/GO_0044292 GO:0010916 biolink:BiologicalProcess negative regulation of very-low-density lipoprotein particle clearance Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json negative regulation of VLDL clearance|negative regulation of VLDL particle clearance http://purl.obolibrary.org/obo/GO_0010916 GO:0010917 biolink:BiologicalProcess negative regulation of mitochondrial membrane potential Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json reduction of mitochondrial membrane potential http://purl.obolibrary.org/obo/GO_0010917 GO:0044293 biolink:CellularComponent dendriole Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC). NIF_Subcellular:sao28175134|NIF_Subcellular:sao295057932 go.json http://purl.obolibrary.org/obo/GO_0044293 GO:0044290 biolink:CellularComponent mitochondrial intracristal space The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space. NIF_Subcellular:sao508958414 go.json http://purl.obolibrary.org/obo/GO_0044290 GO:0044291 biolink:CellularComponent cell-cell contact zone Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. NIF_Subcellular:sao1299635018 go.json cell cell contact zone http://purl.obolibrary.org/obo/GO_0044291 GO:0010910 biolink:BiologicalProcess positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate. go.json http://purl.obolibrary.org/obo/GO_0010910 gocheck_do_not_annotate GO:0010911 biolink:BiologicalProcess regulation of isomerase activity Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. go.json http://purl.obolibrary.org/obo/GO_0010911 gocheck_do_not_annotate GO:0010914 biolink:BiologicalProcess positive regulation of sterigmatocystin biosynthetic process Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. go.json http://purl.obolibrary.org/obo/GO_0010914 GO:0044298 biolink:CellularComponent cell body membrane The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. go.json cell soma membrane http://purl.obolibrary.org/obo/GO_0044298 GO:0044299 biolink:CellularComponent C-fiber The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. NIF_Subcellular:nlx_subcell_20090210 go.json C-fibre http://purl.obolibrary.org/obo/GO_0044299 GO:0010915 biolink:BiologicalProcess regulation of very-low-density lipoprotein particle clearance Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json regulation of VLDL clearance|regulation of VLDL particle clearance http://purl.obolibrary.org/obo/GO_0010915 GO:0044296 biolink:CellularComponent dendritic tuft The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance. NIF_Subcellular:sao1340260079 go.json dendrite tuft http://purl.obolibrary.org/obo/GO_0044296 GO:0010912 biolink:BiologicalProcess positive regulation of isomerase activity Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. go.json http://purl.obolibrary.org/obo/GO_0010912 gocheck_do_not_annotate GO:0044297 biolink:CellularComponent cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. FBbt:00005107|FMA:67301|Wikipedia:Cell_body go.json cell soma http://purl.obolibrary.org/obo/GO_0044297 GO:0010913 biolink:BiologicalProcess regulation of sterigmatocystin biosynthetic process Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. go.json http://purl.obolibrary.org/obo/GO_0010913 GO:0009920 biolink:BiologicalProcess cell plate formation involved in plant-type cell wall biogenesis The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana. go.json cell plate formation involved in cellulose and pectin-containing cell wall biogenesis http://purl.obolibrary.org/obo/GO_0009920 GO:0009921 biolink:CellularComponent auxin efflux carrier complex The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell. go.json http://purl.obolibrary.org/obo/GO_0009921 GO:0009922 biolink:MolecularActivity fatty acid elongase activity Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. EC:2.3.1.199|MetaCyc:RXN-7697|RHEA:32727|Reactome:R-HSA-2046083|Reactome:R-HSA-2046088|Reactome:R-HSA-2046090|Reactome:R-HSA-2046094|Reactome:R-HSA-2046095|Reactome:R-HSA-2046100|Reactome:R-HSA-548800|Reactome:R-HSA-548814|Reactome:R-HSA-548815|Reactome:R-HSA-548830 go.json ELOVL|condensing enzyme|elongation of very long chain fatty acids activity|very-long-chain 3-ketoacyl-CoA synthase|very-long-chain 3-oxoacyl-CoA synthase|very-long-chain beta-ketoacyl-CoA synthase http://purl.obolibrary.org/obo/GO_0009922 GO:0009923 biolink:CellularComponent fatty acid elongase complex A tetrameric complex of four different subunits which catalyzes the elongation of a fatty acid chain 2 carbon units at a time in the synthesis of very long chain fatty acids. go.json http://purl.obolibrary.org/obo/GO_0009923 GO:0009924 biolink:MolecularActivity octadecanal decarbonylase activity Catalysis of the reaction: octadecanal = heptadecane + CO. EC:4.1.99.5|MetaCyc:OCTADECANAL-DECARBONYLASE-RXN|RHEA:30415 go.json octadecanal alkane-lyase activity http://purl.obolibrary.org/obo/GO_0009924 GO:0009925 biolink:CellularComponent basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. go.json http://purl.obolibrary.org/obo/GO_0009925 GO:0009926 biolink:BiologicalProcess auxin polar transport The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. go.json http://purl.obolibrary.org/obo/GO_0009926 GO:0009927 biolink:MolecularActivity histidine phosphotransfer kinase activity Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. go.json http://purl.obolibrary.org/obo/GO_0009927 GO:0009928 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009928 GO:0103085 biolink:MolecularActivity 2-(5'-methylthio)pentylmalate synthase activity Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O = H+ + 2-(5'-methylthio)pentylmalate + coenzyme A. MetaCyc:RXNQT-4169 go.json http://purl.obolibrary.org/obo/GO_0103085 GO:0103086 biolink:MolecularActivity methylthiopentylmalate isomerase activity Catalysis of the reaction: 2-(5'-methylthio)pentylmalate = 3-(5'-methylthio)pentylmalate. MetaCyc:RXNQT-4170 go.json http://purl.obolibrary.org/obo/GO_0103086 GO:0103083 biolink:MolecularActivity methylthiobutylmalate isomerase activity Catalysis of the reaction: 2-(4'-methylthio)butylmalate = 3-(4'-methylthio)butylmalate. MetaCyc:RXNQT-4167 go.json http://purl.obolibrary.org/obo/GO_0103083 GO:0103084 biolink:MolecularActivity obsolete methylthiobutylmalate dehydrogenase activity OBSOLETE. Catalysis of the reaction: 3-(4'-methylthio)butylmalate = H+ + 2-oxo-7-methylthioheptanoate + carbon dioxide. go.json True http://purl.obolibrary.org/obo/GO_0103084 GO:0103089 biolink:MolecularActivity methylthiohexylmalate isomerase activity Catalysis of the reaction: 2-(6'-methylthio)hexylmalate = 3-(6'-methylthio)hexylmalate. MetaCyc:RXNQT-4173 go.json http://purl.obolibrary.org/obo/GO_0103089 GO:0103087 biolink:MolecularActivity obsolete methylthiopentylmalate dehydrogenase activity OBSOLETE. Catalysis of the reaction: 3-(5'-methylthio)pentylmalate = H+ + 2-oxo-8-methylthiooctanoate + carbon dioxide. go.json True http://purl.obolibrary.org/obo/GO_0103087 GO:0103088 biolink:MolecularActivity 2-(6'-methylthio)hexylmalate synthase activity Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O = H+ + 2-(6'-methylthio)hexylmalate + coenzyme A. MetaCyc:RXNQT-4172 go.json http://purl.obolibrary.org/obo/GO_0103088 GO:0103092 biolink:MolecularActivity methylthioalkylmalate isomerase activity Catalysis of the reaction: 2-(7'-methylthio)heptylmalate = 3-(7'-methylthio)heptylmalate. MetaCyc:RXNQT-4176 go.json http://purl.obolibrary.org/obo/GO_0103092 GO:0103093 biolink:MolecularActivity obsolete methylthioalkylmalate dehydrogenase activity OBSOLETE. Catalysis of the reaction: 3-(7'-methylthio)heptylmalate = H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide. go.json True http://purl.obolibrary.org/obo/GO_0103093 GO:0103090 biolink:MolecularActivity obsolete methylthiohexylmalate dehydrogenase activity OBSOLETE. Catalysis of the reaction: 3-(6'-methylthio)hexylmalate = H+ + 2-oxo-9-methylthiononanoate + carbon dioxide. go.json True http://purl.obolibrary.org/obo/GO_0103090 GO:0103091 biolink:MolecularActivity 2-(7'-methylthio)heptylmalate synthase activity Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O = H+ + 2-(7'-methylthio)heptylmalate + coenzyme A. MetaCyc:RXNQT-4175 go.json http://purl.obolibrary.org/obo/GO_0103091 GO:0103096 biolink:MolecularActivity CYP79F1 dihomomethionine monooxygenase activity Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP. MetaCyc:RXNQT-4309|RHEA:32719 go.json http://purl.obolibrary.org/obo/GO_0103096 GO:0009907 biolink:BiologicalProcess response to photoperiod, red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. go.json http://purl.obolibrary.org/obo/GO_0009907 GO:0103097 biolink:MolecularActivity CYP79F1 trihomomethionine monooxygenase activity Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime. MetaCyc:RXNQT-4310|RHEA:32723 go.json http://purl.obolibrary.org/obo/GO_0103097 GO:0009908 biolink:BiologicalProcess flower development The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. go.json http://purl.obolibrary.org/obo/GO_0009908 goslim_plant GO:0009909 biolink:BiologicalProcess regulation of flower development Any process that modulates the frequency, rate or extent of flower development. go.json http://purl.obolibrary.org/obo/GO_0009909 GO:0103095 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0103095 GO:0103098 biolink:MolecularActivity CYP79F1 tetrahomomethionine monooxygenase activity Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH = 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime. MetaCyc:RXNQT-4311 go.json http://purl.obolibrary.org/obo/GO_0103098 GO:0103099 biolink:MolecularActivity UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate = H+ + 4-methylthiobutyldesulfoglucosinolate + UDP. EC:2.4.1.195|MetaCyc:RXNQT-4324 go.json http://purl.obolibrary.org/obo/GO_0103099 GO:0009900 biolink:BiologicalProcess dehiscence The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it. Wikipedia:Dehiscence_(botany) go.json http://purl.obolibrary.org/obo/GO_0009900 GO:0009901 biolink:BiologicalProcess anther dehiscence The dehiscence of an anther to release the pollen grains contained within it. go.json http://purl.obolibrary.org/obo/GO_0009901 GO:0009902 biolink:BiologicalProcess chloroplast relocation The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery. go.json chloroplast movement http://purl.obolibrary.org/obo/GO_0009902 GO:0009903 biolink:BiologicalProcess chloroplast avoidance movement The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery. go.json high-fluence-rate response http://purl.obolibrary.org/obo/GO_0009903 GO:0009904 biolink:BiologicalProcess chloroplast accumulation movement The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis. go.json low-fluence-rate response http://purl.obolibrary.org/obo/GO_0009904 GO:0009905 biolink:MolecularActivity ent-copalyl diphosphate synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate. EC:5.5.1.13|KEGG_REACTION:R02068|MetaCyc:5.5.1.13-RXN|RHEA:14841 go.json diterpene cyclase activity|ent-copalyl-diphosphate lyase (decyclizing)|ent-kaurene synthase A activity|ent-kaurene synthetase A activity http://purl.obolibrary.org/obo/GO_0009905 GO:0009906 biolink:BiologicalProcess response to photoperiod, blue light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. go.json http://purl.obolibrary.org/obo/GO_0009906 GO:1903349 biolink:CellularComponent omegasome membrane Any membrane that is part of an omegasome. go.json http://purl.obolibrary.org/obo/GO_1903349 GO:1903348 biolink:BiologicalProcess positive regulation of bicellular tight junction assembly Any process that activates or increases the frequency, rate or extent of tight junction assembly. go.json activation of tight junction assembly|activation of tight junction formation|positive regulation of tight junction formation|up regulation of tight junction assembly|up regulation of tight junction formation|up-regulation of tight junction assembly|up-regulation of tight junction formation|upregulation of tight junction assembly|upregulation of tight junction formation http://purl.obolibrary.org/obo/GO_1903348 GO:1903347 biolink:BiologicalProcess negative regulation of bicellular tight junction assembly Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly. go.json down regulation of tight junction assembly|down regulation of tight junction formation|down-regulation of tight junction assembly|down-regulation of tight junction formation|downregulation of tight junction assembly|downregulation of tight junction formation|inhibition of tight junction assembly|inhibition of tight junction formation|negative regulation of tight junction formation http://purl.obolibrary.org/obo/GO_1903347 GO:1903346 biolink:BiologicalProcess positive regulation of protein polyglycylation Any process that activates or increases the frequency, rate or extent of protein polyglycylation. go.json activation of protein polyglycylation|up regulation of protein polyglycylation|up-regulation of protein polyglycylation|upregulation of protein polyglycylation http://purl.obolibrary.org/obo/GO_1903346 GO:1903345 biolink:BiologicalProcess negative regulation of protein polyglycylation Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation. go.json down regulation of protein polyglycylation|down-regulation of protein polyglycylation|downregulation of protein polyglycylation|inhibition of protein polyglycylation http://purl.obolibrary.org/obo/GO_1903345 GO:1903344 biolink:BiologicalProcess regulation of protein polyglycylation Any process that modulates the frequency, rate or extent of protein polyglycylation. go.json http://purl.obolibrary.org/obo/GO_1903344 GO:1903343 biolink:BiologicalProcess positive regulation of meiotic DNA double-strand break formation Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation. go.json activation of meiotic DNA double-strand break formation|up regulation of meiotic DNA double-strand break formation|up-regulation of meiotic DNA double-strand break formation|upregulation of meiotic DNA double-strand break formation http://purl.obolibrary.org/obo/GO_1903343 GO:1903353 biolink:BiologicalProcess regulation of nucleus organization Any process that modulates the frequency, rate or extent of nucleus organization. go.json regulation of nuclear morphology|regulation of nuclear organisation|regulation of nuclear organization|regulation of nuclear organization and biogenesis|regulation of nucleus organization and biogenesis http://purl.obolibrary.org/obo/GO_1903353 GO:1903352 biolink:BiologicalProcess L-ornithine transmembrane transport The directed movement of L-ornithine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903352 GO:1903351 biolink:BiologicalProcess cellular response to dopamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1903351 GO:1903350 biolink:BiologicalProcess response to dopamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1903350 GO:1903359 biolink:BiologicalProcess lateral cortical node assembly The aggregation, arrangement and bonding together of a set of components to form a lateral cortical node. go.json Skb1-containing cortical node assembly|Skb1-containing cortical node formation|lateral cortical node formation http://purl.obolibrary.org/obo/GO_1903359 GO:1903358 biolink:BiologicalProcess regulation of Golgi organization Any process that modulates the frequency, rate or extent of Golgi organization. go.json regulation of Golgi organisation|regulation of Golgi organization and biogenesis http://purl.obolibrary.org/obo/GO_1903358 GO:1903357 biolink:BiologicalProcess regulation of transcription initiation by RNA polymerase I Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter. go.json regulation of transcription initiation from RNA polymerase I promoter|regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript http://purl.obolibrary.org/obo/GO_1903357 GO:1903356 biolink:BiologicalProcess positive regulation of distal tip cell migration Any process that activates or increases the frequency, rate or extent of distal tip cell migration. go.json activation of distal tip cell migration|up regulation of distal tip cell migration|up-regulation of distal tip cell migration|upregulation of distal tip cell migration http://purl.obolibrary.org/obo/GO_1903356 GO:1903355 biolink:BiologicalProcess negative regulation of distal tip cell migration Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration. go.json down regulation of distal tip cell migration|down-regulation of distal tip cell migration|downregulation of distal tip cell migration|inhibition of distal tip cell migration http://purl.obolibrary.org/obo/GO_1903355 GO:1903354 biolink:BiologicalProcess regulation of distal tip cell migration Any process that modulates the frequency, rate or extent of distal tip cell migration. go.json http://purl.obolibrary.org/obo/GO_1903354 GO:1903364 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903364 GO:1903363 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903363 GO:1903362 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903362 GO:1903361 biolink:BiologicalProcess protein localization to basolateral plasma membrane Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane. go.json basolateral protein localization|protein localisation in basolateral plasma membrane|protein localisation to basolateral plasma membrane|protein localization in basolateral plasma membrane http://purl.obolibrary.org/obo/GO_1903361 GO:1903360 biolink:BiologicalProcess protein localization to lateral cortical node A process in which a protein is transported to, or maintained in, a location within a lateral cortical node. go.json protein localisation in lateral cortical node|protein localisation to lateral cortical node|protein localization in lateral cortical node http://purl.obolibrary.org/obo/GO_1903360 GO:1903369 biolink:BiologicalProcess negative regulation of foraging behavior Any process that stops, prevents or reduces the frequency, rate or extent of foraging behavior. go.json down regulation of foraging behavior|down-regulation of foraging behavior|downregulation of foraging behavior|inhibition of foraging behavior http://purl.obolibrary.org/obo/GO_1903369 GO:1903368 biolink:BiologicalProcess regulation of foraging behavior Any process that modulates the frequency, rate or extent of foraging behavior. go.json http://purl.obolibrary.org/obo/GO_1903368 GO:1903367 biolink:BiologicalProcess positive regulation of fear response Any process that activates or increases the frequency, rate or extent of fear response. go.json activation of fear response|activation of physiological fear response|positive regulation of physiological fear response|up regulation of fear response|up regulation of physiological fear response|up-regulation of fear response|up-regulation of physiological fear response|upregulation of fear response|upregulation of physiological fear response http://purl.obolibrary.org/obo/GO_1903367 GO:1903366 biolink:BiologicalProcess negative regulation of fear response Any process that stops, prevents or reduces the frequency, rate or extent of fear response. go.json down regulation of fear response|down regulation of physiological fear response|down-regulation of fear response|down-regulation of physiological fear response|downregulation of fear response|downregulation of physiological fear response|inhibition of fear response|inhibition of physiological fear response|negative regulation of physiological fear response http://purl.obolibrary.org/obo/GO_1903366 GO:1903365 biolink:BiologicalProcess regulation of fear response Any process that modulates the frequency, rate or extent of fear response. go.json regulation of physiological fear response http://purl.obolibrary.org/obo/GO_1903365 GO:1903375 biolink:BiologicalProcess facioacoustic ganglion development The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure. go.json acoustico-facial VII-VIII ganglion complex development|acousticofacial ganglion development|facio-acoustic VII-VIII ganglion complex development|facio-acoustic ganglion complex VII-VIII development|facio-acoustic ganglion development http://purl.obolibrary.org/obo/GO_1903375 GO:1903374 biolink:BiologicalProcess obsolete subarachnoid space development OBSOLETE. The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure. go.json cavitas subarachnoidea development|cavum subarachnoideale development|spatium leptomeningeum development|spatium subarachnoideum development|subarachnoid cavity development True http://purl.obolibrary.org/obo/GO_1903374 GO:1903373 biolink:BiologicalProcess positive regulation of endoplasmic reticulum tubular network organization Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization. go.json activation of ER tubular network organisation|activation of ER tubular network organization|activation of endoplasmic reticulum tubular network organisation|activation of endoplasmic reticulum tubular network organization|positive regulation of ER tubular network organisation|positive regulation of ER tubular network organization|positive regulation of endoplasmic reticulum tubular network organisation|up regulation of ER tubular network organisation|up regulation of ER tubular network organization|up regulation of endoplasmic reticulum tubular network organisation|up regulation of endoplasmic reticulum tubular network organization|up-regulation of ER tubular network organisation|up-regulation of ER tubular network organization|up-regulation of endoplasmic reticulum tubular network organisation|up-regulation of endoplasmic reticulum tubular network organization|upregulation of ER tubular network organisation|upregulation of ER tubular network organization|upregulation of endoplasmic reticulum tubular network organisation|upregulation of endoplasmic reticulum tubular network organization http://purl.obolibrary.org/obo/GO_1903373 GO:1903372 biolink:BiologicalProcess negative regulation of endoplasmic reticulum tubular network organization Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum tubular network organization. go.json down regulation of ER tubular network organisation|down regulation of ER tubular network organization|down regulation of endoplasmic reticulum tubular network organisation|down regulation of endoplasmic reticulum tubular network organization|down-regulation of ER tubular network organisation|down-regulation of ER tubular network organization|down-regulation of endoplasmic reticulum tubular network organisation|down-regulation of endoplasmic reticulum tubular network organization|downregulation of ER tubular network organisation|downregulation of ER tubular network organization|downregulation of endoplasmic reticulum tubular network organisation|downregulation of endoplasmic reticulum tubular network organization|inhibition of ER tubular network organisation|inhibition of ER tubular network organization|inhibition of endoplasmic reticulum tubular network organisation|inhibition of endoplasmic reticulum tubular network organization|negative regulation of ER tubular network organisation|negative regulation of ER tubular network organization|negative regulation of endoplasmic reticulum tubular network organisation http://purl.obolibrary.org/obo/GO_1903372 GO:1903371 biolink:BiologicalProcess regulation of endoplasmic reticulum tubular network organization Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization. go.json regulation of ER tubular network organisation|regulation of ER tubular network organization|regulation of endoplasmic reticulum tubular network organisation http://purl.obolibrary.org/obo/GO_1903371 GO:1903370 biolink:BiologicalProcess positive regulation of foraging behavior Any process that activates or increases the frequency, rate or extent of foraging behavior. go.json activation of foraging behavior|up regulation of foraging behavior|up-regulation of foraging behavior|upregulation of foraging behavior http://purl.obolibrary.org/obo/GO_1903370 GO:1903379 biolink:BiologicalProcess regulation of mitotic chromosome condensation Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. go.json http://purl.obolibrary.org/obo/GO_1903379 GO:1903378 biolink:BiologicalProcess positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. go.json activation of neuron apoptosis in response to oxidative stress|activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|positive regulation of neuron apoptosis in response to oxidative stress|positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|up regulation of neuron apoptosis in response to oxidative stress|up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|up-regulation of neuron apoptosis in response to oxidative stress|up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|upregulation of neuron apoptosis in response to oxidative stress|upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress http://purl.obolibrary.org/obo/GO_1903378 GO:1903377 biolink:BiologicalProcess negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. go.json down regulation of neuron apoptosis in response to oxidative stress|down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|down-regulation of neuron apoptosis in response to oxidative stress|down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|downregulation of neuron apoptosis in response to oxidative stress|downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|inhibition of neuron apoptosis in response to oxidative stress|inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of neuron apoptosis in response to oxidative stress|negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of oxidative stress-induced neuron apoptosis|neuroprotection against oxidative stress-induced apoptosis|protection against oxidative stress-induced neuron apoptosis|protection against oxidative stress-induced neuronal apoptosis http://purl.obolibrary.org/obo/GO_1903377 GO:1903376 biolink:BiologicalProcess regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. go.json regulation of neuron apoptosis in response to oxidative stress|regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of oxidative stress-induced neuron apoptosis|regulation of oxidative stress-induced neuronal apoptosis http://purl.obolibrary.org/obo/GO_1903376 GO:1903386 biolink:BiologicalProcess negative regulation of homophilic cell adhesion Any process that stops, prevents or reduces the frequency, rate or extent of homophilic cell adhesion. go.json down regulation of homophilic cell adhesion|down-regulation of homophilic cell adhesion|downregulation of homophilic cell adhesion|inhibition of homophilic cell adhesion http://purl.obolibrary.org/obo/GO_1903386 GO:1903385 biolink:BiologicalProcess regulation of homophilic cell adhesion Any process that modulates the frequency, rate or extent of homophilic cell adhesion. go.json http://purl.obolibrary.org/obo/GO_1903385 GO:1903384 biolink:BiologicalProcess negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. go.json down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|down regulation of neuron apoptosis in response to hydrogen peroxide|down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|down-regulation of neuron apoptosis in response to hydrogen peroxide|down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|downregulation of neuron apoptosis in response to hydrogen peroxide|downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway|inhibition of neuron apoptosis in response to hydrogen peroxide|inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2|inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|negative regulation of neuron apoptosis in response to hydrogen peroxide|negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|protection against H2O2-induced neuron apoptosis|protection against hydrogen peroxide-induced neuron apoptosis http://purl.obolibrary.org/obo/GO_1903384 GO:1903383 biolink:BiologicalProcess regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. go.json regulation of H2O2-induced neuron apoptosis|regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|regulation of hydrogen peroxide-induced neuron apoptosis|regulation of hydrogen peroxide-induced neuronal apoptosis|regulation of neuron apoptosis in response to hydrogen peroxide|regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide http://purl.obolibrary.org/obo/GO_1903383 GO:1903382 biolink:BiologicalProcess negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. go.json down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway|inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1903382 GO:1903381 biolink:BiologicalProcess regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. go.json regulation of ER stress-induced neuron apoptosis|regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|regulation of endoplasmic reticulum stress-induced neuron apoptosis|regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1903381 GO:1903380 biolink:BiologicalProcess positive regulation of mitotic chromosome condensation Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. go.json activation of mitotic chromosome condensation|up regulation of mitotic chromosome condensation|up-regulation of mitotic chromosome condensation|upregulation of mitotic chromosome condensation http://purl.obolibrary.org/obo/GO_1903380 GO:1903389 biolink:BiologicalProcess negative regulation of synaptic vesicle uncoating Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating. go.json down regulation of synaptic vesicle coat depolymerization|down regulation of synaptic vesicle coat protein depolymerization|down regulation of synaptic vesicle uncoating|down-regulation of synaptic vesicle coat depolymerization|down-regulation of synaptic vesicle coat protein depolymerization|down-regulation of synaptic vesicle uncoating|downregulation of synaptic vesicle coat depolymerization|downregulation of synaptic vesicle coat protein depolymerization|downregulation of synaptic vesicle uncoating|inhibition of synaptic vesicle coat depolymerization|inhibition of synaptic vesicle coat protein depolymerization|inhibition of synaptic vesicle uncoating|negative regulation of synaptic vesicle coat depolymerization|negative regulation of synaptic vesicle coat protein depolymerization http://purl.obolibrary.org/obo/GO_1903389 GO:1903388 biolink:BiologicalProcess regulation of synaptic vesicle uncoating Any process that modulates the frequency, rate or extent of synaptic vesicle uncoating. go.json regulation of synaptic vesicle coat depolymerization|regulation of synaptic vesicle coat protein depolymerization http://purl.obolibrary.org/obo/GO_1903388 GO:1903387 biolink:BiologicalProcess positive regulation of homophilic cell adhesion Any process that activates or increases the frequency, rate or extent of homophilic cell adhesion. go.json activation of homophilic cell adhesion|up regulation of homophilic cell adhesion|up-regulation of homophilic cell adhesion|upregulation of homophilic cell adhesion http://purl.obolibrary.org/obo/GO_1903387 GO:1903397 biolink:BiologicalProcess positive regulation of secondary cell septum biogenesis Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis. go.json activation of secondary cell septum biogenesis|up regulation of secondary cell septum biogenesis|up-regulation of secondary cell septum biogenesis|upregulation of secondary cell septum biogenesis http://purl.obolibrary.org/obo/GO_1903397 GO:1903396 biolink:BiologicalProcess negative regulation of secondary cell septum biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis. go.json down regulation of secondary cell septum biogenesis|down-regulation of secondary cell septum biogenesis|downregulation of secondary cell septum biogenesis|inhibition of secondary cell septum biogenesis http://purl.obolibrary.org/obo/GO_1903396 GO:1903395 biolink:BiologicalProcess regulation of secondary cell septum biogenesis Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis. go.json http://purl.obolibrary.org/obo/GO_1903395 GO:1903394 biolink:BiologicalProcess protein localization to kinetochore involved in kinetochore assembly Any protein localization to kinetochore that is involved in kinetochore assembly. go.json condensin localization to kinetochore involved in centromere and kinetochore complex maturation|condensin localization to kinetochore involved in centromere/kinetochore complex maturation|condensin localization to kinetochore involved in chromosome-kinetochore attachment|condensin localization to kinetochore involved in kinetochore assembly|condensin localization to kinetochore involved in kinetochore formation|protein localisation to kinetochore involved in centromere and kinetochore complex maturation|protein localisation to kinetochore involved in centromere/kinetochore complex maturation|protein localisation to kinetochore involved in chromosome-kinetochore attachment|protein localisation to kinetochore involved in kinetochore assembly|protein localisation to kinetochore involved in kinetochore formation|protein localization to kinetochore involved in centromere and kinetochore complex maturation|protein localization to kinetochore involved in centromere/kinetochore complex maturation|protein localization to kinetochore involved in chromosome-kinetochore attachment|protein localization to kinetochore involved in kinetochore formation http://purl.obolibrary.org/obo/GO_1903394 GO:1903393 biolink:BiologicalProcess positive regulation of adherens junction organization Any process that activates or increases the frequency, rate or extent of adherens junction organization. go.json activation of adherens junction assembly and maintenance|activation of adherens junction organisation|activation of adherens junction organization|positive regulation of adherens junction assembly and maintenance|positive regulation of adherens junction organisation|up regulation of adherens junction assembly and maintenance|up regulation of adherens junction organisation|up regulation of adherens junction organization|up-regulation of adherens junction assembly and maintenance|up-regulation of adherens junction organisation|up-regulation of adherens junction organization|upregulation of adherens junction assembly and maintenance|upregulation of adherens junction organisation|upregulation of adherens junction organization http://purl.obolibrary.org/obo/GO_1903393 GO:1903392 biolink:BiologicalProcess negative regulation of adherens junction organization Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. go.json down regulation of adherens junction assembly and maintenance|down regulation of adherens junction organisation|down regulation of adherens junction organization|down-regulation of adherens junction assembly and maintenance|down-regulation of adherens junction organisation|down-regulation of adherens junction organization|downregulation of adherens junction assembly and maintenance|downregulation of adherens junction organisation|downregulation of adherens junction organization|inhibition of adherens junction assembly and maintenance|inhibition of adherens junction organisation|inhibition of adherens junction organization|negative regulation of adherens junction assembly and maintenance|negative regulation of adherens junction organisation http://purl.obolibrary.org/obo/GO_1903392 GO:1903391 biolink:BiologicalProcess regulation of adherens junction organization Any process that modulates the frequency, rate or extent of adherens junction organization. go.json regulation of adherens junction assembly and maintenance|regulation of adherens junction organisation http://purl.obolibrary.org/obo/GO_1903391 GO:1903390 biolink:BiologicalProcess positive regulation of synaptic vesicle uncoating Any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating. go.json activation of synaptic vesicle coat depolymerization|activation of synaptic vesicle coat protein depolymerization|activation of synaptic vesicle uncoating|positive regulation of synaptic vesicle coat depolymerization|positive regulation of synaptic vesicle coat protein depolymerization|up regulation of synaptic vesicle coat depolymerization|up regulation of synaptic vesicle coat protein depolymerization|up regulation of synaptic vesicle uncoating|up-regulation of synaptic vesicle coat depolymerization|up-regulation of synaptic vesicle coat protein depolymerization|up-regulation of synaptic vesicle uncoating|upregulation of synaptic vesicle coat depolymerization|upregulation of synaptic vesicle coat protein depolymerization|upregulation of synaptic vesicle uncoating http://purl.obolibrary.org/obo/GO_1903390 GO:1903399 biolink:BiologicalProcess obsolete positive regulation of m7G(5')pppN diphosphatase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity. go.json activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|activation of M(7)G(5')pppN pyrophosphatase activity|activation of decapase activity|activation of m7G(5')pppN diphosphatase activity|activation of m7G(5')pppN pyrophosphatase activity|positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|positive regulation of M(7)G(5')pppN pyrophosphatase activity|positive regulation of decapase activity|positive regulation of m7G(5')pppN pyrophosphatase activity|up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|up regulation of M(7)G(5')pppN pyrophosphatase activity|up regulation of decapase activity|up regulation of m7G(5')pppN diphosphatase activity|up regulation of m7G(5')pppN pyrophosphatase activity|up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|up-regulation of M(7)G(5')pppN pyrophosphatase activity|up-regulation of decapase activity|up-regulation of m7G(5')pppN diphosphatase activity|up-regulation of m7G(5')pppN pyrophosphatase activity|upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|upregulation of M(7)G(5')pppN pyrophosphatase activity|upregulation of decapase activity|upregulation of m7G(5')pppN diphosphatase activity|upregulation of m7G(5')pppN pyrophosphatase activity True http://purl.obolibrary.org/obo/GO_1903399 GO:1903398 biolink:BiologicalProcess obsolete regulation of m7G(5')pppN diphosphatase activity OBSOLETE. Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity. go.json regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity|regulation of M(7)G(5')pppN pyrophosphatase activity|regulation of decapase activity|regulation of m7G(5')pppN pyrophosphatase activity True http://purl.obolibrary.org/obo/GO_1903398 GO:1903309 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903309 GO:1903308 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903308 GO:1903307 biolink:BiologicalProcess positive regulation of regulated secretory pathway Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. go.json activation of regulated secretory pathway|up regulation of regulated secretory pathway|up-regulation of regulated secretory pathway|upregulation of regulated secretory pathway http://purl.obolibrary.org/obo/GO_1903307 GO:1903306 biolink:BiologicalProcess negative regulation of regulated secretory pathway Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. go.json down regulation of regulated secretory pathway|down-regulation of regulated secretory pathway|downregulation of regulated secretory pathway|inhibition of regulated secretory pathway http://purl.obolibrary.org/obo/GO_1903306 GO:1903305 biolink:BiologicalProcess regulation of regulated secretory pathway Any process that modulates the frequency, rate or extent of regulated secretory pathway. go.json http://purl.obolibrary.org/obo/GO_1903305 GO:1903304 biolink:BiologicalProcess positive regulation of pyruvate kinase activity Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity. go.json activation of ATP:pyruvate 2-O-phosphotransferase activity|activation of phosphoenol transphosphorylase activity|activation of phosphoenolpyruvate kinase activity|activation of pyruvate kinase activity|positive regulation of ATP:pyruvate 2-O-phosphotransferase activity|positive regulation of phosphoenol transphosphorylase activity|positive regulation of phosphoenolpyruvate kinase activity|up regulation of ATP:pyruvate 2-O-phosphotransferase activity|up regulation of phosphoenol transphosphorylase activity|up regulation of phosphoenolpyruvate kinase activity|up regulation of pyruvate kinase activity|up-regulation of ATP:pyruvate 2-O-phosphotransferase activity|up-regulation of phosphoenol transphosphorylase activity|up-regulation of phosphoenolpyruvate kinase activity|up-regulation of pyruvate kinase activity|upregulation of ATP:pyruvate 2-O-phosphotransferase activity|upregulation of phosphoenol transphosphorylase activity|upregulation of phosphoenolpyruvate kinase activity|upregulation of pyruvate kinase activity http://purl.obolibrary.org/obo/GO_1903304 gocheck_do_not_annotate GO:1903303 biolink:BiologicalProcess negative regulation of pyruvate kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity. go.json down regulation of ATP:pyruvate 2-O-phosphotransferase activity|down regulation of phosphoenol transphosphorylase activity|down regulation of phosphoenolpyruvate kinase activity|down regulation of pyruvate kinase activity|down-regulation of ATP:pyruvate 2-O-phosphotransferase activity|down-regulation of phosphoenol transphosphorylase activity|down-regulation of phosphoenolpyruvate kinase activity|down-regulation of pyruvate kinase activity|downregulation of ATP:pyruvate 2-O-phosphotransferase activity|downregulation of phosphoenol transphosphorylase activity|downregulation of phosphoenolpyruvate kinase activity|downregulation of pyruvate kinase activity|inhibition of ATP:pyruvate 2-O-phosphotransferase activity|inhibition of phosphoenol transphosphorylase activity|inhibition of phosphoenolpyruvate kinase activity|inhibition of pyruvate kinase activity|negative regulation of ATP:pyruvate 2-O-phosphotransferase activity|negative regulation of phosphoenol transphosphorylase activity|negative regulation of phosphoenolpyruvate kinase activity http://purl.obolibrary.org/obo/GO_1903303 gocheck_do_not_annotate GO:1903302 biolink:BiologicalProcess regulation of pyruvate kinase activity Any process that modulates the frequency, rate or extent of pyruvate kinase activity. go.json regulation of ATP:pyruvate 2-O-phosphotransferase activity|regulation of phosphoenol transphosphorylase activity|regulation of phosphoenolpyruvate kinase activity http://purl.obolibrary.org/obo/GO_1903302 gocheck_do_not_annotate GO:1903301 biolink:BiologicalProcess positive regulation of hexokinase activity Any process that activates or increases the frequency, rate or extent of hexokinase activity. go.json activation of ATP-dependent hexokinase activity|activation of ATP:D-hexose 6-phosphotransferase activity|activation of glucose ATP phosphotransferase activity|activation of hexokinase (phosphorylating)|activation of hexokinase D|activation of hexokinase activity|activation of hexokinase type I activity|activation of hexokinase type II activity|activation of hexokinase type III activity|activation of hexokinase type IV|activation of hexokinase type IV (glucokinase) activity|activation of hexokinase type IV glucokinase activity|positive regulation of ATP-dependent hexokinase activity|positive regulation of ATP:D-hexose 6-phosphotransferase activity|positive regulation of glucose ATP phosphotransferase activity|positive regulation of hexokinase (phosphorylating)|positive regulation of hexokinase D|positive regulation of hexokinase type I activity|positive regulation of hexokinase type II activity|positive regulation of hexokinase type III activity|positive regulation of hexokinase type IV|positive regulation of hexokinase type IV (glucokinase) activity|positive regulation of hexokinase type IV glucokinase activity|up regulation of ATP-dependent hexokinase activity|up regulation of ATP:D-hexose 6-phosphotransferase activity|up regulation of glucose ATP phosphotransferase activity|up regulation of hexokinase (phosphorylating)|up regulation of hexokinase D|up regulation of hexokinase activity|up regulation of hexokinase type I activity|up regulation of hexokinase type II activity|up regulation of hexokinase type III activity|up regulation of hexokinase type IV|up regulation of hexokinase type IV (glucokinase) activity|up regulation of hexokinase type IV glucokinase activity|up-regulation of ATP-dependent hexokinase activity|up-regulation of ATP:D-hexose 6-phosphotransferase activity|up-regulation of glucose ATP phosphotransferase activity|up-regulation of hexokinase (phosphorylating)|up-regulation of hexokinase D|up-regulation of hexokinase activity|up-regulation of hexokinase type I activity|up-regulation of hexokinase type II activity|up-regulation of hexokinase type III activity|up-regulation of hexokinase type IV|up-regulation of hexokinase type IV (glucokinase) activity|up-regulation of hexokinase type IV glucokinase activity|upregulation of ATP-dependent hexokinase activity|upregulation of ATP:D-hexose 6-phosphotransferase activity|upregulation of glucose ATP phosphotransferase activity|upregulation of hexokinase (phosphorylating)|upregulation of hexokinase D|upregulation of hexokinase activity|upregulation of hexokinase type I activity|upregulation of hexokinase type II activity|upregulation of hexokinase type III activity|upregulation of hexokinase type IV|upregulation of hexokinase type IV (glucokinase) activity|upregulation of hexokinase type IV glucokinase activity http://purl.obolibrary.org/obo/GO_1903301 gocheck_do_not_annotate GO:1903300 biolink:BiologicalProcess negative regulation of hexokinase activity Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity. go.json down regulation of ATP-dependent hexokinase activity|down regulation of ATP:D-hexose 6-phosphotransferase activity|down regulation of glucose ATP phosphotransferase activity|down regulation of hexokinase (phosphorylating)|down regulation of hexokinase D|down regulation of hexokinase activity|down regulation of hexokinase type I activity|down regulation of hexokinase type II activity|down regulation of hexokinase type III activity|down regulation of hexokinase type IV|down regulation of hexokinase type IV (glucokinase) activity|down regulation of hexokinase type IV glucokinase activity|down-regulation of ATP-dependent hexokinase activity|down-regulation of ATP:D-hexose 6-phosphotransferase activity|down-regulation of glucose ATP phosphotransferase activity|down-regulation of hexokinase (phosphorylating)|down-regulation of hexokinase D|down-regulation of hexokinase activity|down-regulation of hexokinase type I activity|down-regulation of hexokinase type II activity|down-regulation of hexokinase type III activity|down-regulation of hexokinase type IV|down-regulation of hexokinase type IV (glucokinase) activity|down-regulation of hexokinase type IV glucokinase activity|downregulation of ATP-dependent hexokinase activity|downregulation of ATP:D-hexose 6-phosphotransferase activity|downregulation of glucose ATP phosphotransferase activity|downregulation of hexokinase (phosphorylating)|downregulation of hexokinase D|downregulation of hexokinase activity|downregulation of hexokinase type I activity|downregulation of hexokinase type II activity|downregulation of hexokinase type III activity|downregulation of hexokinase type IV|downregulation of hexokinase type IV (glucokinase) activity|downregulation of hexokinase type IV glucokinase activity|inhibition of ATP-dependent hexokinase activity|inhibition of ATP:D-hexose 6-phosphotransferase activity|inhibition of glucose ATP phosphotransferase activity|inhibition of hexokinase (phosphorylating)|inhibition of hexokinase D|inhibition of hexokinase activity|inhibition of hexokinase type I activity|inhibition of hexokinase type II activity|inhibition of hexokinase type III activity|inhibition of hexokinase type IV|inhibition of hexokinase type IV (glucokinase) activity|inhibition of hexokinase type IV glucokinase activity|negative regulation of ATP-dependent hexokinase activity|negative regulation of ATP:D-hexose 6-phosphotransferase activity|negative regulation of glucose ATP phosphotransferase activity|negative regulation of hexokinase (phosphorylating)|negative regulation of hexokinase D|negative regulation of hexokinase type I activity|negative regulation of hexokinase type II activity|negative regulation of hexokinase type III activity|negative regulation of hexokinase type IV|negative regulation of hexokinase type IV (glucokinase) activity|negative regulation of hexokinase type IV glucokinase activity http://purl.obolibrary.org/obo/GO_1903300 gocheck_do_not_annotate GO:1903319 biolink:BiologicalProcess positive regulation of protein maturation Any process that activates or increases the frequency, rate or extent of protein maturation. go.json activation of protein maturation|up regulation of protein maturation|up-regulation of protein maturation|upregulation of protein maturation http://purl.obolibrary.org/obo/GO_1903319 GO:1903318 biolink:BiologicalProcess negative regulation of protein maturation Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. go.json down regulation of protein maturation|down-regulation of protein maturation|downregulation of protein maturation|inhibition of protein maturation http://purl.obolibrary.org/obo/GO_1903318 GO:1903317 biolink:BiologicalProcess regulation of protein maturation Any process that modulates the frequency, rate or extent of protein maturation. go.json http://purl.obolibrary.org/obo/GO_1903317 GO:1903316 biolink:BiologicalProcess positive regulation of nitrogen cycle metabolic process Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process. go.json activation of nitrogen cycle metabolic process|up regulation of nitrogen cycle metabolic process|up-regulation of nitrogen cycle metabolic process|upregulation of nitrogen cycle metabolic process http://purl.obolibrary.org/obo/GO_1903316 GO:1903315 biolink:BiologicalProcess negative regulation of nitrogen cycle metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process. go.json down regulation of nitrogen cycle metabolic process|down-regulation of nitrogen cycle metabolic process|downregulation of nitrogen cycle metabolic process|inhibition of nitrogen cycle metabolic process http://purl.obolibrary.org/obo/GO_1903315 GO:1903314 biolink:BiologicalProcess regulation of nitrogen cycle metabolic process Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process. go.json http://purl.obolibrary.org/obo/GO_1903314 GO:1903313 biolink:BiologicalProcess positive regulation of mRNA metabolic process Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. go.json activation of mRNA metabolic process|activation of mRNA metabolism|positive regulation of mRNA metabolism|up regulation of mRNA metabolic process|up regulation of mRNA metabolism|up-regulation of mRNA metabolic process|up-regulation of mRNA metabolism|upregulation of mRNA metabolic process|upregulation of mRNA metabolism http://purl.obolibrary.org/obo/GO_1903313 GO:1903312 biolink:BiologicalProcess negative regulation of mRNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. go.json down regulation of mRNA metabolic process|down regulation of mRNA metabolism|down-regulation of mRNA metabolic process|down-regulation of mRNA metabolism|downregulation of mRNA metabolic process|downregulation of mRNA metabolism|inhibition of mRNA metabolic process|inhibition of mRNA metabolism|negative regulation of mRNA metabolism http://purl.obolibrary.org/obo/GO_1903312 GO:1903311 biolink:BiologicalProcess regulation of mRNA metabolic process Any process that modulates the frequency, rate or extent of mRNA metabolic process. go.json regulation of mRNA metabolism http://purl.obolibrary.org/obo/GO_1903311 GO:1903310 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903310 GO:1903320 biolink:BiologicalProcess regulation of protein modification by small protein conjugation or removal Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. go.json http://purl.obolibrary.org/obo/GO_1903320 GO:1903329 biolink:BiologicalProcess regulation of iron-sulfur cluster assembly Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly. go.json http://purl.obolibrary.org/obo/GO_1903329 GO:1903328 biolink:BiologicalProcess positive regulation of tRNA metabolic process Any process that activates or increases the frequency, rate or extent of tRNA metabolic process. go.json activation of tRNA metabolic process|activation of tRNA metabolism|positive regulation of tRNA metabolism|up regulation of tRNA metabolic process|up regulation of tRNA metabolism|up-regulation of tRNA metabolic process|up-regulation of tRNA metabolism|upregulation of tRNA metabolic process|upregulation of tRNA metabolism http://purl.obolibrary.org/obo/GO_1903328 GO:1903327 biolink:BiologicalProcess negative regulation of tRNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process. go.json down regulation of tRNA metabolic process|down regulation of tRNA metabolism|down-regulation of tRNA metabolic process|down-regulation of tRNA metabolism|downregulation of tRNA metabolic process|downregulation of tRNA metabolism|inhibition of tRNA metabolic process|inhibition of tRNA metabolism|negative regulation of tRNA metabolism http://purl.obolibrary.org/obo/GO_1903327 GO:1903326 biolink:BiologicalProcess regulation of tRNA metabolic process Any process that modulates the frequency, rate or extent of tRNA metabolic process. go.json regulation of tRNA metabolism http://purl.obolibrary.org/obo/GO_1903326 GO:1903325 biolink:BiologicalProcess positive regulation of snoRNA metabolic process Any process that activates or increases the frequency, rate or extent of snoRNA metabolic process. go.json activation of snoRNA metabolic process|activation of snoRNA metabolism|positive regulation of snoRNA metabolism|up regulation of snoRNA metabolic process|up regulation of snoRNA metabolism|up-regulation of snoRNA metabolic process|up-regulation of snoRNA metabolism|upregulation of snoRNA metabolic process|upregulation of snoRNA metabolism http://purl.obolibrary.org/obo/GO_1903325 GO:1903324 biolink:BiologicalProcess negative regulation of snoRNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA metabolic process. go.json down regulation of snoRNA metabolic process|down regulation of snoRNA metabolism|down-regulation of snoRNA metabolic process|down-regulation of snoRNA metabolism|downregulation of snoRNA metabolic process|downregulation of snoRNA metabolism|inhibition of snoRNA metabolic process|inhibition of snoRNA metabolism|negative regulation of snoRNA metabolism http://purl.obolibrary.org/obo/GO_1903324 GO:1903323 biolink:BiologicalProcess regulation of snoRNA metabolic process Any process that modulates the frequency, rate or extent of snoRNA metabolic process. go.json regulation of snoRNA metabolism http://purl.obolibrary.org/obo/GO_1903323 GO:1903322 biolink:BiologicalProcess positive regulation of protein modification by small protein conjugation or removal Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. go.json activation of protein modification by small protein conjugation or removal|up regulation of protein modification by small protein conjugation or removal|up-regulation of protein modification by small protein conjugation or removal|upregulation of protein modification by small protein conjugation or removal http://purl.obolibrary.org/obo/GO_1903322 GO:1903321 biolink:BiologicalProcess negative regulation of protein modification by small protein conjugation or removal Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. go.json down regulation of protein modification by small protein conjugation or removal|down-regulation of protein modification by small protein conjugation or removal|downregulation of protein modification by small protein conjugation or removal|inhibition of protein modification by small protein conjugation or removal http://purl.obolibrary.org/obo/GO_1903321 GO:1903331 biolink:BiologicalProcess positive regulation of iron-sulfur cluster assembly Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly. go.json activation of iron-sulfur cluster assembly|activation of iron-sulfur cluster biosynthesis|activation of iron-sulphur cluster assembly|positive regulation of iron-sulfur cluster biosynthesis|positive regulation of iron-sulphur cluster assembly|up regulation of iron-sulfur cluster assembly|up regulation of iron-sulfur cluster biosynthesis|up regulation of iron-sulphur cluster assembly|up-regulation of iron-sulfur cluster assembly|up-regulation of iron-sulfur cluster biosynthesis|up-regulation of iron-sulphur cluster assembly|upregulation of iron-sulfur cluster assembly|upregulation of iron-sulfur cluster biosynthesis|upregulation of iron-sulphur cluster assembly http://purl.obolibrary.org/obo/GO_1903331 GO:1903330 biolink:BiologicalProcess negative regulation of iron-sulfur cluster assembly Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly. go.json down regulation of iron-sulfur cluster assembly|down regulation of iron-sulfur cluster biosynthesis|down regulation of iron-sulphur cluster assembly|down-regulation of iron-sulfur cluster assembly|down-regulation of iron-sulfur cluster biosynthesis|down-regulation of iron-sulphur cluster assembly|downregulation of iron-sulfur cluster assembly|downregulation of iron-sulfur cluster biosynthesis|downregulation of iron-sulphur cluster assembly|inhibition of iron-sulfur cluster assembly|inhibition of iron-sulfur cluster biosynthesis|inhibition of iron-sulphur cluster assembly|negative regulation of iron-sulfur cluster biosynthesis|negative regulation of iron-sulphur cluster assembly http://purl.obolibrary.org/obo/GO_1903330 GO:1903339 biolink:BiologicalProcess negative regulation of cell wall organization or biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis. go.json down regulation of cell wall organisation or biogenesis|down regulation of cell wall organization or biogenesis|down regulation of cell wall organization or biogenesis at cellular level|down regulation of cellular cell wall organisation or biogenesis|down regulation of cellular cell wall organization or biogenesis|down-regulation of cell wall organisation or biogenesis|down-regulation of cell wall organization or biogenesis|down-regulation of cell wall organization or biogenesis at cellular level|down-regulation of cellular cell wall organisation or biogenesis|down-regulation of cellular cell wall organization or biogenesis|downregulation of cell wall organisation or biogenesis|downregulation of cell wall organization or biogenesis|downregulation of cell wall organization or biogenesis at cellular level|downregulation of cellular cell wall organisation or biogenesis|downregulation of cellular cell wall organization or biogenesis|inhibition of cell wall organisation or biogenesis|inhibition of cell wall organization or biogenesis|inhibition of cell wall organization or biogenesis at cellular level|inhibition of cellular cell wall organisation or biogenesis|inhibition of cellular cell wall organization or biogenesis|negative regulation of cell wall organisation or biogenesis|negative regulation of cell wall organization or biogenesis at cellular level|negative regulation of cellular cell wall organisation or biogenesis|negative regulation of cellular cell wall organization or biogenesis http://purl.obolibrary.org/obo/GO_1903339 GO:1903338 biolink:BiologicalProcess regulation of cell wall organization or biogenesis Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis. go.json regulation of cell wall organisation or biogenesis|regulation of cell wall organization or biogenesis at cellular level|regulation of cellular cell wall organisation or biogenesis|regulation of cellular cell wall organization or biogenesis http://purl.obolibrary.org/obo/GO_1903338 GO:1903337 biolink:BiologicalProcess positive regulation of vacuolar transport Any process that activates or increases the frequency, rate or extent of vacuolar transport. go.json activation of vacuolar transport|up regulation of vacuolar transport|up-regulation of vacuolar transport|upregulation of vacuolar transport http://purl.obolibrary.org/obo/GO_1903337 GO:1903336 biolink:BiologicalProcess negative regulation of vacuolar transport Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. go.json down regulation of vacuolar transport|down-regulation of vacuolar transport|downregulation of vacuolar transport|inhibition of vacuolar transport http://purl.obolibrary.org/obo/GO_1903336 GO:1903335 biolink:BiologicalProcess regulation of vacuolar transport Any process that modulates the frequency, rate or extent of vacuolar transport. go.json http://purl.obolibrary.org/obo/GO_1903335 GO:1903334 biolink:BiologicalProcess positive regulation of protein folding Any process that activates or increases the frequency, rate or extent of protein folding. go.json activation of alpha-tubulin folding|activation of beta-tubulin folding|activation of chaperone activity|activation of chaperonin ATPase activity|activation of chaperonin-mediated tubulin folding|activation of co-chaperone activity|activation of co-chaperonin activity|activation of glycoprotein-specific chaperone activity|activation of non-chaperonin molecular chaperone ATPase activity|activation of protein complex assembly, multichaperone pathway|activation of protein folding|positive regulation of alpha-tubulin folding|positive regulation of beta-tubulin folding|positive regulation of chaperone activity|positive regulation of chaperonin ATPase activity|positive regulation of chaperonin-mediated tubulin folding|positive regulation of co-chaperone activity|positive regulation of co-chaperonin activity|positive regulation of glycoprotein-specific chaperone activity|positive regulation of non-chaperonin molecular chaperone ATPase activity|positive regulation of protein complex assembly, multichaperone pathway|up regulation of alpha-tubulin folding|up regulation of beta-tubulin folding|up regulation of chaperone activity|up regulation of chaperonin ATPase activity|up regulation of chaperonin-mediated tubulin folding|up regulation of co-chaperone activity|up regulation of co-chaperonin activity|up regulation of glycoprotein-specific chaperone activity|up regulation of non-chaperonin molecular chaperone ATPase activity|up regulation of protein complex assembly, multichaperone pathway|up regulation of protein folding|up-regulation of alpha-tubulin folding|up-regulation of beta-tubulin folding|up-regulation of chaperone activity|up-regulation of chaperonin ATPase activity|up-regulation of chaperonin-mediated tubulin folding|up-regulation of co-chaperone activity|up-regulation of co-chaperonin activity|up-regulation of glycoprotein-specific chaperone activity|up-regulation of non-chaperonin molecular chaperone ATPase activity|up-regulation of protein complex assembly, multichaperone pathway|up-regulation of protein folding|upregulation of alpha-tubulin folding|upregulation of beta-tubulin folding|upregulation of chaperone activity|upregulation of chaperonin ATPase activity|upregulation of chaperonin-mediated tubulin folding|upregulation of co-chaperone activity|upregulation of co-chaperonin activity|upregulation of glycoprotein-specific chaperone activity|upregulation of non-chaperonin molecular chaperone ATPase activity|upregulation of protein complex assembly, multichaperone pathway|upregulation of protein folding http://purl.obolibrary.org/obo/GO_1903334 GO:1903333 biolink:BiologicalProcess negative regulation of protein folding Any process that stops, prevents or reduces the frequency, rate or extent of protein folding. go.json down regulation of alpha-tubulin folding|down regulation of beta-tubulin folding|down regulation of chaperone activity|down regulation of chaperonin ATPase activity|down regulation of chaperonin-mediated tubulin folding|down regulation of co-chaperone activity|down regulation of co-chaperonin activity|down regulation of glycoprotein-specific chaperone activity|down regulation of non-chaperonin molecular chaperone ATPase activity|down regulation of protein complex assembly, multichaperone pathway|down regulation of protein folding|down-regulation of alpha-tubulin folding|down-regulation of beta-tubulin folding|down-regulation of chaperone activity|down-regulation of chaperonin ATPase activity|down-regulation of chaperonin-mediated tubulin folding|down-regulation of co-chaperone activity|down-regulation of co-chaperonin activity|down-regulation of glycoprotein-specific chaperone activity|down-regulation of non-chaperonin molecular chaperone ATPase activity|down-regulation of protein complex assembly, multichaperone pathway|down-regulation of protein folding|downregulation of alpha-tubulin folding|downregulation of beta-tubulin folding|downregulation of chaperone activity|downregulation of chaperonin ATPase activity|downregulation of chaperonin-mediated tubulin folding|downregulation of co-chaperone activity|downregulation of co-chaperonin activity|downregulation of glycoprotein-specific chaperone activity|downregulation of non-chaperonin molecular chaperone ATPase activity|downregulation of protein complex assembly, multichaperone pathway|downregulation of protein folding|inhibition of alpha-tubulin folding|inhibition of beta-tubulin folding|inhibition of chaperone activity|inhibition of chaperonin ATPase activity|inhibition of chaperonin-mediated tubulin folding|inhibition of co-chaperone activity|inhibition of co-chaperonin activity|inhibition of glycoprotein-specific chaperone activity|inhibition of non-chaperonin molecular chaperone ATPase activity|inhibition of protein complex assembly, multichaperone pathway|inhibition of protein folding|negative regulation of alpha-tubulin folding|negative regulation of beta-tubulin folding|negative regulation of chaperone activity|negative regulation of chaperonin ATPase activity|negative regulation of chaperonin-mediated tubulin folding|negative regulation of co-chaperone activity|negative regulation of co-chaperonin activity|negative regulation of glycoprotein-specific chaperone activity|negative regulation of non-chaperonin molecular chaperone ATPase activity|negative regulation of protein complex assembly, multichaperone pathway http://purl.obolibrary.org/obo/GO_1903333 GO:1903332 biolink:BiologicalProcess regulation of protein folding Any process that modulates the frequency, rate or extent of protein folding. go.json regulation of alpha-tubulin folding|regulation of beta-tubulin folding|regulation of chaperone activity|regulation of chaperonin ATPase activity|regulation of chaperonin-mediated tubulin folding|regulation of co-chaperone activity|regulation of co-chaperonin activity|regulation of glycoprotein-specific chaperone activity|regulation of non-chaperonin molecular chaperone ATPase activity|regulation of protein complex assembly, multichaperone pathway http://purl.obolibrary.org/obo/GO_1903332 GO:1903342 biolink:BiologicalProcess negative regulation of meiotic DNA double-strand break formation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation. go.json down regulation of meiotic DNA double-strand break formation|down-regulation of meiotic DNA double-strand break formation|downregulation of meiotic DNA double-strand break formation|inhibition of meiotic DNA double-strand break formation http://purl.obolibrary.org/obo/GO_1903342 GO:1903341 biolink:BiologicalProcess regulation of meiotic DNA double-strand break formation Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation. go.json http://purl.obolibrary.org/obo/GO_1903341 GO:1903340 biolink:BiologicalProcess positive regulation of cell wall organization or biogenesis Any process that activates or increases the frequency, rate or extent of cell wall organization or biogenesis. go.json activation of cell wall organisation or biogenesis|activation of cell wall organization or biogenesis|activation of cell wall organization or biogenesis at cellular level|activation of cellular cell wall organisation or biogenesis|activation of cellular cell wall organization or biogenesis|positive regulation of cell wall organisation or biogenesis|positive regulation of cell wall organization or biogenesis at cellular level|positive regulation of cellular cell wall organisation or biogenesis|positive regulation of cellular cell wall organization or biogenesis|up regulation of cell wall organisation or biogenesis|up regulation of cell wall organization or biogenesis|up regulation of cell wall organization or biogenesis at cellular level|up regulation of cellular cell wall organisation or biogenesis|up regulation of cellular cell wall organization or biogenesis|up-regulation of cell wall organisation or biogenesis|up-regulation of cell wall organization or biogenesis|up-regulation of cell wall organization or biogenesis at cellular level|up-regulation of cellular cell wall organisation or biogenesis|up-regulation of cellular cell wall organization or biogenesis|upregulation of cell wall organisation or biogenesis|upregulation of cell wall organization or biogenesis|upregulation of cell wall organization or biogenesis at cellular level|upregulation of cellular cell wall organisation or biogenesis|upregulation of cellular cell wall organization or biogenesis http://purl.obolibrary.org/obo/GO_1903340 GO:0097079 biolink:MolecularActivity selenite:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in). go.json selenite:H+ symporter activity|selenite:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0097079 GO:0097078 biolink:CellularComponent FAL1-SGD1 complex A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits. go.json http://purl.obolibrary.org/obo/GO_0097078 GO:0097075 biolink:CellularComponent interferon regulatory factor 3-interferon regulatory factor 7 complex An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7. go.json IRF3:IRF7 complex http://purl.obolibrary.org/obo/GO_0097075 GO:0097074 biolink:CellularComponent interferon regulatory factor 7 complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7. go.json IRF7:IRF7 complex http://purl.obolibrary.org/obo/GO_0097074 GO:0097077 biolink:MolecularActivity copper ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+). go.json http://purl.obolibrary.org/obo/GO_0097077 GO:0097076 biolink:CellularComponent transforming growth factor beta activated kinase 1 complex A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits). go.json TAK1 kinase complex http://purl.obolibrary.org/obo/GO_0097076 GO:0097071 biolink:CellularComponent interferon regulatory factor complex A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. go.json IRF complex http://purl.obolibrary.org/obo/GO_0097071 GO:0097070 biolink:BiologicalProcess ductus arteriosus closure The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs. go.json http://purl.obolibrary.org/obo/GO_0097070 GO:0097073 biolink:CellularComponent interferon regulatory factor 5 complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5. go.json IRF5:IRF5 complex http://purl.obolibrary.org/obo/GO_0097073 GO:0097072 biolink:CellularComponent interferon regulatory factor 3 complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3. go.json IRF3:IRF3 complex http://purl.obolibrary.org/obo/GO_0097072 GO:0097089 biolink:BiologicalProcess methyl-branched fatty acid metabolic process The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain. go.json methyl-branched fatty acid metabolism http://purl.obolibrary.org/obo/GO_0097089 GO:0097086 biolink:BiologicalProcess amniotic stem cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone. go.json http://purl.obolibrary.org/obo/GO_0097086 GO:0097085 biolink:CellularComponent interferon regulatory factor 3-interferon regulatory factor 5 complex An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5. go.json IRF3:IRF5 complex http://purl.obolibrary.org/obo/GO_0097085 GO:0097088 biolink:BiologicalProcess interleukin-17F production The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-17F production http://purl.obolibrary.org/obo/GO_0097088 gocheck_do_not_annotate GO:0097087 biolink:BiologicalProcess interleukin-17A production The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-17A production|interleukin-17A biosynthetic process http://purl.obolibrary.org/obo/GO_0097087 gocheck_do_not_annotate GO:0097082 biolink:BiologicalProcess vascular associated smooth muscle cell fate specification The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. go.json vascular smooth muscle cell fate specification http://purl.obolibrary.org/obo/GO_0097082 GO:0097081 biolink:BiologicalProcess vascular associated smooth muscle cell fate commitment The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. go.json vascular smooth muscle cell fate commitment http://purl.obolibrary.org/obo/GO_0097081 GO:0097084 biolink:BiologicalProcess vascular associated smooth muscle cell development The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. go.json vascular smooth muscle cell development http://purl.obolibrary.org/obo/GO_0097084 GO:0097083 biolink:BiologicalProcess vascular associated smooth muscle cell fate determination The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. go.json vascular smooth muscle cell fate determination http://purl.obolibrary.org/obo/GO_0097083 GO:0097080 biolink:BiologicalProcess plasma membrane selenite transport The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane. go.json plasma membrane hydrogenselenite transport http://purl.obolibrary.org/obo/GO_0097080 GO:0097057 biolink:CellularComponent TRAF2-GSTP1 complex A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses. go.json http://purl.obolibrary.org/obo/GO_0097057 GO:0097056 biolink:BiologicalProcess obsolete selenocysteinyl-tRNA(Sec) biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine. go.json selenocysteinyl-tRNA(Sec) anabolism|selenocysteinyl-tRNA(Sec) biosynthesis|selenocysteinyl-tRNA(Sec) formation|selenocysteinyl-tRNA(Sec) synthesis True http://purl.obolibrary.org/obo/GO_0097056 GO:0097059 biolink:CellularComponent CNTFR-CLCF1 complex A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space. go.json sCNTFR-CLC complex http://purl.obolibrary.org/obo/GO_0097059 GO:0097058 biolink:CellularComponent CRLF-CLCF1 complex A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex. go.json CLF-CLC complex http://purl.obolibrary.org/obo/GO_0097058 GO:0097053 biolink:BiologicalProcess L-kynurenine catabolic process The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). go.json L-kynurenine breakdown|L-kynurenine catabolism|L-kynurenine degradation http://purl.obolibrary.org/obo/GO_0097053 GO:0097052 biolink:BiologicalProcess L-kynurenine metabolic process The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). go.json L-kynurenine metabolism http://purl.obolibrary.org/obo/GO_0097052 GO:0097055 biolink:BiologicalProcess agmatine biosynthetic process The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. go.json agmatine anabolism|agmatine biosynthesis|agmatine formation|agmatine synthesis http://purl.obolibrary.org/obo/GO_0097055 GO:0097054 biolink:BiologicalProcess L-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid. go.json L-glutamate anabolism|L-glutamate biosynthesis|L-glutamate formation|L-glutamate synthesis http://purl.obolibrary.org/obo/GO_0097054 GO:0097051 biolink:BiologicalProcess establishment of protein localization to endoplasmic reticulum membrane The directed movement of a protein to a specific location in the endoplasmic reticulum membrane. go.json establishment of protein localisation in endoplasmic reticulum membrane|establishment of protein localization in endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0097051 GO:0097050 biolink:BiologicalProcess type B pancreatic cell apoptotic process Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. go.json pancreatic B cell apoptosis|pancreatic beta cell apoptosis|type B pancreatic cell apoptosis http://purl.obolibrary.org/obo/GO_0097050 GO:0097068 biolink:BiologicalProcess response to thyroxine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. go.json response to T4|response to T4 stimulus|response to thyroxine stimulus http://purl.obolibrary.org/obo/GO_0097068 GO:0097067 biolink:BiologicalProcess cellular response to thyroid hormone stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_0097067 GO:0097069 biolink:BiologicalProcess cellular response to thyroxine stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. go.json cellular response to T4 stimulus http://purl.obolibrary.org/obo/GO_0097069 GO:0097064 biolink:BiologicalProcess ncRNA export from nucleus The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm. go.json non-coding RNA export from nucleus http://purl.obolibrary.org/obo/GO_0097064 GO:0097063 biolink:MolecularActivity cadmium ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). go.json http://purl.obolibrary.org/obo/GO_0097063 GO:0097066 biolink:BiologicalProcess response to thyroid hormone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. go.json response to thyroid hormone stimulus http://purl.obolibrary.org/obo/GO_0097066 GO:0097065 biolink:BiologicalProcess anterior head development The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0097065 GO:0097060 biolink:CellularComponent synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. go.json http://purl.obolibrary.org/obo/GO_0097060 goslim_synapse GO:0097062 biolink:BiologicalProcess dendritic spine maintenance The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0097062 GO:0097061 biolink:BiologicalProcess dendritic spine organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. go.json dendritic spine organisation http://purl.obolibrary.org/obo/GO_0097061 GO:0097097 biolink:BiologicalProcess nasal suture morphogenesis The process in which the nasal suture is generated and organized. go.json internasal suture morphogenesis http://purl.obolibrary.org/obo/GO_0097097 GO:0097096 biolink:BiologicalProcess facial suture morphogenesis The process in which any suture between facial bones is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0097096 GO:0097099 biolink:MolecularActivity structural constituent of albumen The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo. go.json structural constituent of egg white http://purl.obolibrary.org/obo/GO_0097099 GO:0097098 biolink:MolecularActivity DNA/RNA hybrid annealing activity An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops. go.json http://purl.obolibrary.org/obo/GO_0097098 GO:0097093 biolink:BiologicalProcess polyacyltrehalose biosynthetic process The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid. go.json polyacyltrehalose anabolism|polyacyltrehalose biosynthesis|polyacyltrehalose formation|polyacyltrehalose synthesis http://purl.obolibrary.org/obo/GO_0097093 GO:0097092 biolink:BiologicalProcess polyacyltrehalose metabolic process The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid. go.json polyacyltrehalose metabolism http://purl.obolibrary.org/obo/GO_0097092 GO:0097095 biolink:BiologicalProcess frontonasal suture morphogenesis The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized. go.json nasofrontal suture morphogenesis http://purl.obolibrary.org/obo/GO_0097095 GO:0097094 biolink:BiologicalProcess craniofacial suture morphogenesis The process in which any suture between cranial and/or facial bones is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0097094 GO:0097091 biolink:BiologicalProcess synaptic vesicle clustering The process that results in grouping synaptic vesicles in presynaptic structures. go.json http://purl.obolibrary.org/obo/GO_0097091 goslim_synapse GO:0097090 biolink:BiologicalProcess presynaptic membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. go.json pre-synaptic membrane organization|presynaptic membrane organisation http://purl.obolibrary.org/obo/GO_0097090 GO:0048068 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048068 GO:0048067 biolink:BiologicalProcess cuticle pigmentation Establishment of a pattern of pigment in the cuticle of an organism. go.json http://purl.obolibrary.org/obo/GO_0048067 GO:0048066 biolink:BiologicalProcess developmental pigmentation The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. go.json pigmentation during development http://purl.obolibrary.org/obo/GO_0048066 GO:0048065 biolink:BiologicalProcess male courtship behavior, veined wing extension The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster. go.json male courtship behavior, wing extension|male courtship behaviour, veined wing extension|male courtship behaviour, wing extension http://purl.obolibrary.org/obo/GO_0048065 GO:0048064 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048064 GO:0048063 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048063 GO:0048062 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048062 GO:0048061 biolink:BiologicalProcess positive gravitaxis The directed movement of a motile cell or organism towards the source of gravity. go.json positive geotactic behavior|positive geotactic behaviour|positive gravitactic behavior|positive gravitactic behaviour|positive taxis in response to gravity|positive taxis in response to gravitytaxis in response to gravitational stimulus http://purl.obolibrary.org/obo/GO_0048061 GO:1903229 biolink:BiologicalProcess xanthosine biosynthetic process The chemical reactions and pathways resulting in the formation of xanthosine. go.json xanthosine anabolism|xanthosine biosynthesis|xanthosine formation|xanthosine synthesis http://purl.obolibrary.org/obo/GO_1903229 GO:0014728 biolink:BiologicalProcess regulation of the force of skeletal muscle contraction Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges. go.json http://purl.obolibrary.org/obo/GO_0014728 GO:1903228 biolink:BiologicalProcess xanthosine catabolic process The chemical reactions and pathways resulting in the breakdown of xanthosine. go.json xanthosine breakdown|xanthosine catabolism|xanthosine degradation http://purl.obolibrary.org/obo/GO_1903228 GO:0014727 biolink:BiologicalProcess positive regulation of extraocular skeletal muscle development Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. go.json http://purl.obolibrary.org/obo/GO_0014727 GO:1903227 biolink:BiologicalProcess xanthosine metabolic process The chemical reactions and pathways involving xanthosine. go.json xanthosine metabolism http://purl.obolibrary.org/obo/GO_1903227 GO:0014726 biolink:BiologicalProcess negative regulation of extraocular skeletal muscle development Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. go.json http://purl.obolibrary.org/obo/GO_0014726 GO:1903226 biolink:BiologicalProcess positive regulation of endodermal cell differentiation Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. go.json activation of endoderm cell differentiation|activation of endodermal cell differentiation|positive regulation of endoderm cell differentiation|up regulation of endoderm cell differentiation|up regulation of endodermal cell differentiation|up-regulation of endoderm cell differentiation|up-regulation of endodermal cell differentiation|upregulation of endoderm cell differentiation|upregulation of endodermal cell differentiation http://purl.obolibrary.org/obo/GO_1903226 GO:0014725 biolink:BiologicalProcess regulation of extraocular skeletal muscle development Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. go.json http://purl.obolibrary.org/obo/GO_0014725 GO:1903225 biolink:BiologicalProcess negative regulation of endodermal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. go.json down regulation of endoderm cell differentiation|down regulation of endodermal cell differentiation|down-regulation of endoderm cell differentiation|down-regulation of endodermal cell differentiation|downregulation of endoderm cell differentiation|downregulation of endodermal cell differentiation|inhibition of endoderm cell differentiation|inhibition of endodermal cell differentiation|negative regulation of endoderm cell differentiation http://purl.obolibrary.org/obo/GO_1903225 GO:1903224 biolink:BiologicalProcess regulation of endodermal cell differentiation Any process that modulates the frequency, rate or extent of endodermal cell differentiation. go.json regulation of endoderm cell differentiation http://purl.obolibrary.org/obo/GO_1903224 GO:1903223 biolink:BiologicalProcess obsolete positive regulation of oxidative stress-induced neuron death OBSOLETE. Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death. go.json activation of neuron death in response to oxidative stress|activation of neuronal cell death in response to oxidative stress|activation of oxidative stress-induced neuron death|positive regulation of neuron death in response to oxidative stress|positive regulation of neuronal cell death in response to oxidative stress|sensitization of neuron to oxidative stress-induced cell death|up regulation of neuron death in response to oxidative stress|up regulation of neuronal cell death in response to oxidative stress|up regulation of oxidative stress-induced neuron death|up-regulation of neuron death in response to oxidative stress|up-regulation of neuronal cell death in response to oxidative stress|up-regulation of oxidative stress-induced neuron death|upregulation of neuron death in response to oxidative stress|upregulation of neuronal cell death in response to oxidative stress|upregulation of oxidative stress-induced neuron death True http://purl.obolibrary.org/obo/GO_1903223 GO:0048069 biolink:BiologicalProcess eye pigmentation Establishment of a pattern of pigment in the eye of an organism. Wikipedia:Eye_color go.json http://purl.obolibrary.org/obo/GO_0048069 GO:1903222 biolink:BiologicalProcess quinolinic acid transmembrane transport The process in which quinolinic acid is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903222 GO:0014729 biolink:BiologicalProcess regulation of the velocity of shortening of skeletal muscle modulating contraction Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres. go.json regulation of the velocity of shortening of skeletal muscle during contraction http://purl.obolibrary.org/obo/GO_0014729 GO:1903232 biolink:BiologicalProcess melanosome assembly The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. go.json melanosome formation http://purl.obolibrary.org/obo/GO_1903232 GO:0014720 biolink:BiologicalProcess tonic skeletal muscle contraction A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue. go.json http://purl.obolibrary.org/obo/GO_0014720 GO:1903231 biolink:MolecularActivity mRNA base-pairing translational repressor activity A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing. go.json RNA binding involved in PTGS|RNA binding involved in cosuppression|RNA binding involved in post-transcriptional gene silencing|RNA binding involved in posttranscriptional gene silencing|RNA binding involved in quelling|mRNA base-pairing post-transcriptional repressor activity|mRNA base-pairing posttranscriptional repressor activity|mRNA binding involved in PTGS|mRNA binding involved in cosuppression|mRNA binding involved in post-transcriptional gene silencing|mRNA binding involved in posttranscriptional gene silencing|mRNA binding involved in quelling|mRNA binding translation repressor activity|translational inhibitor activity via mRNA base-pairing http://purl.obolibrary.org/obo/GO_1903231 GO:1903230 biolink:MolecularActivity obsolete miRNA binding involved in posttranscriptional gene silencing OBSOLETE. Any miRNA binding that is involved in posttranscriptional gene silencing. go.json miRNA binding involved in PTGS|miRNA binding involved in cosuppression|miRNA binding involved in post-transcriptional gene silencing|miRNA binding involved in posttranscriptional gene silencing|miRNA binding involved in quelling|microRNA binding involved in PTGS|microRNA binding involved in cosuppression|microRNA binding involved in post-transcriptional gene silencing|microRNA binding involved in posttranscriptional gene silencing|microRNA binding involved in quelling True http://purl.obolibrary.org/obo/GO_1903230 GO:0014724 biolink:BiologicalProcess regulation of twitch skeletal muscle contraction Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014724 GO:0014723 biolink:BiologicalProcess regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril. go.json regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0014723 GO:0014722 biolink:BiologicalProcess regulation of skeletal muscle contraction by calcium ion signaling Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction. go.json regulation of skeletal muscle contraction by calcium ion signalling http://purl.obolibrary.org/obo/GO_0014722 GO:0014721 biolink:BiologicalProcess twitch skeletal muscle contraction A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation. go.json http://purl.obolibrary.org/obo/GO_0014721 GO:0048071 biolink:BiologicalProcess sex-specific pigmentation Establishment of a pattern of pigment in one sex that is not observed in the other sex. go.json http://purl.obolibrary.org/obo/GO_0048071 GO:0048070 biolink:BiologicalProcess regulation of developmental pigmentation Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. go.json regulation of pigmentation during development http://purl.obolibrary.org/obo/GO_0048070 GO:0048079 biolink:BiologicalProcess regulation of cuticle pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. go.json http://purl.obolibrary.org/obo/GO_0048079 GO:0097002 biolink:CellularComponent mitochondrial inner boundary membrane The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane. NIF_Subcellular:sao18461326 go.json inner bounding mitochondrial membrane http://purl.obolibrary.org/obo/GO_0097002 GO:0048078 biolink:BiologicalProcess positive regulation of compound eye pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye. go.json activation of eye pigmentation|positive regulation of eye pigmentation|stimulation of eye pigmentation|up regulation of eye pigmentation|up-regulation of eye pigmentation|upregulation of eye pigmentation http://purl.obolibrary.org/obo/GO_0048078 GO:0097001 biolink:MolecularActivity ceramide binding Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes. go.json http://purl.obolibrary.org/obo/GO_0097001 GO:0048077 biolink:BiologicalProcess negative regulation of compound eye pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye. go.json down regulation of eye pigmentation|down-regulation of eye pigmentation|downregulation of eye pigmentation|inhibition of eye pigmentation|negative regulation of eye pigmentation http://purl.obolibrary.org/obo/GO_0048077 GO:0097004 biolink:MolecularActivity adipokinetic hormone binding Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. go.json AKH binding http://purl.obolibrary.org/obo/GO_0097004 GO:0048076 biolink:BiologicalProcess regulation of compound eye pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye. go.json http://purl.obolibrary.org/obo/GO_0048076 GO:0097003 biolink:MolecularActivity adipokinetic hormone receptor activity Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. go.json AKH receptor activity http://purl.obolibrary.org/obo/GO_0097003 GO:0048075 biolink:BiologicalProcess positive regulation of eye pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. go.json activation of eye pigmentation|stimulation of eye pigmentation|up regulation of eye pigmentation|up-regulation of eye pigmentation|upregulation of eye pigmentation http://purl.obolibrary.org/obo/GO_0048075 GO:0048074 biolink:BiologicalProcess negative regulation of eye pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. go.json down regulation of eye pigmentation|down-regulation of eye pigmentation|downregulation of eye pigmentation|inhibition of eye pigmentation http://purl.obolibrary.org/obo/GO_0048074 GO:0048073 biolink:BiologicalProcess regulation of eye pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. go.json http://purl.obolibrary.org/obo/GO_0048073 GO:0048072 biolink:BiologicalProcess compound eye pigmentation Establishment of a pattern of pigment in the compound eye. go.json http://purl.obolibrary.org/obo/GO_0048072 GO:0014739 biolink:BiologicalProcess positive regulation of muscle hyperplasia Any process that activates or increases the frequency, rate or extent of muscle hyperplasia. go.json http://purl.obolibrary.org/obo/GO_0014739 GO:1903239 biolink:BiologicalProcess obsolete regulation of positive regulation of the force of heart contraction by chemical signal OBSOLETE. Any process that modulates the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal. go.json regulation of positive regulation of the force of heart contraction by chemical signal|regulation of positive regulation of the force of heart muscle contraction by chemical signal True http://purl.obolibrary.org/obo/GO_1903239 GO:0014738 biolink:BiologicalProcess regulation of muscle hyperplasia Any process that modulates the frequency, rate or extent of muscle hyperplasia. go.json http://purl.obolibrary.org/obo/GO_0014738 GO:0014737 biolink:BiologicalProcess positive regulation of muscle atrophy Any process that activates or increases the frequency, rate or extent of muscle atrophy. go.json http://purl.obolibrary.org/obo/GO_0014737 GO:1903238 biolink:BiologicalProcess positive regulation of leukocyte tethering or rolling Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling. go.json activation of leukocyte tethering or rolling|up regulation of leukocyte tethering or rolling|up-regulation of leukocyte tethering or rolling|upregulation of leukocyte tethering or rolling http://purl.obolibrary.org/obo/GO_1903238 GO:1903237 biolink:BiologicalProcess negative regulation of leukocyte tethering or rolling Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling. go.json down regulation of leukocyte tethering or rolling|down-regulation of leukocyte tethering or rolling|downregulation of leukocyte tethering or rolling|inhibition of leukocyte tethering or rolling http://purl.obolibrary.org/obo/GO_1903237 GO:0014736 biolink:BiologicalProcess negative regulation of muscle atrophy Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy. go.json http://purl.obolibrary.org/obo/GO_0014736 GO:1903236 biolink:BiologicalProcess regulation of leukocyte tethering or rolling Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling. go.json http://purl.obolibrary.org/obo/GO_1903236 GO:1903235 biolink:BiologicalProcess positive regulation of calcium ion-dependent exocytosis of neurotransmitter Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. go.json activation of calcium ion-dependent exocytosis of neurotransmitter|up regulation of calcium ion-dependent exocytosis of neurotransmitter|up-regulation of calcium ion-dependent exocytosis of neurotransmitter|upregulation of calcium ion-dependent exocytosis of neurotransmitter http://purl.obolibrary.org/obo/GO_1903235 GO:1903234 biolink:BiologicalProcess negative regulation of calcium ion-dependent exocytosis of neurotransmitter Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. go.json down regulation of calcium ion-dependent exocytosis of neurotransmitter|down-regulation of calcium ion-dependent exocytosis of neurotransmitter|downregulation of calcium ion-dependent exocytosis of neurotransmitter|inhibition of calcium ion-dependent exocytosis of neurotransmitter http://purl.obolibrary.org/obo/GO_1903234 GO:1903233 biolink:BiologicalProcess regulation of calcium ion-dependent exocytosis of neurotransmitter Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_1903233 GO:0014731 biolink:CellularComponent spectrin-associated cytoskeleton The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0014731 GO:1903243 biolink:BiologicalProcess negative regulation of cardiac muscle hypertrophy in response to stress Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. go.json down regulation of cardiac muscle hypertrophy in response to stress|down-regulation of cardiac muscle hypertrophy in response to stress|downregulation of cardiac muscle hypertrophy in response to stress|inhibition of cardiac muscle hypertrophy in response to stress http://purl.obolibrary.org/obo/GO_1903243 GO:1903242 biolink:BiologicalProcess regulation of cardiac muscle hypertrophy in response to stress Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. go.json http://purl.obolibrary.org/obo/GO_1903242 GO:0014730 biolink:BiologicalProcess skeletal muscle regeneration at neuromuscular junction The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers. go.json http://purl.obolibrary.org/obo/GO_0014730 GO:1903241 biolink:BiologicalProcess U2-type prespliceosome assembly The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome. go.json GT-AG prespliceosome assembly|GT-AG prespliceosome formation|U2-type prespliceosome formation|major prespliceosome assembly|major prespliceosome formation|mammalian U2-type spliceosomal complex A assembly|mammalian U2-type spliceosomal complex A formation|yeast U2-type spliceosomal complex B assembly|yeast U2-type spliceosomal complex B formation http://purl.obolibrary.org/obo/GO_1903241 GO:1903240 biolink:BiologicalProcess obsolete negative regulation of positive regulation of the force of heart contraction by chemical signal OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal. go.json down regulation of positive regulation of the force of heart contraction by chemical signal|down regulation of positive regulation of the force of heart muscle contraction by chemical signal|down-regulation of positive regulation of the force of heart contraction by chemical signal|down-regulation of positive regulation of the force of heart muscle contraction by chemical signal|downregulation of positive regulation of the force of heart contraction by chemical signal|downregulation of positive regulation of the force of heart muscle contraction by chemical signal|inhibition of positive regulation of the force of heart contraction by chemical signal|inhibition of positive regulation of the force of heart muscle contraction by chemical signal|negative regulation of positive regulation of the force of heart contraction by chemical signal|negative regulation of positive regulation of the force of heart muscle contraction by chemical signal True http://purl.obolibrary.org/obo/GO_1903240 GO:0014735 biolink:BiologicalProcess regulation of muscle atrophy Any process that modulates the frequency, rate or extent of muscle atrophy. go.json http://purl.obolibrary.org/obo/GO_0014735 GO:0014734 biolink:BiologicalProcess skeletal muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. go.json http://purl.obolibrary.org/obo/GO_0014734 GO:0014733 biolink:BiologicalProcess regulation of skeletal muscle adaptation Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. go.json regulation of skeletal muscle plasticity http://purl.obolibrary.org/obo/GO_0014733 GO:0014732 biolink:BiologicalProcess skeletal muscle atrophy A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. go.json http://purl.obolibrary.org/obo/GO_0014732 GO:0048082 biolink:BiologicalProcess regulation of adult chitin-containing cuticle pigmentation Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. go.json http://purl.obolibrary.org/obo/GO_0048082 GO:0097009 biolink:BiologicalProcess energy homeostasis Any process involved in the balance between food intake (energy input) and energy expenditure. go.json negative regulation of energy homeostasis|positive regulation of energy homeostasis|regulation of energy homeostasis http://purl.obolibrary.org/obo/GO_0097009 GO:0048081 biolink:BiologicalProcess positive regulation of cuticle pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. go.json activation of cuticle pigmentation|stimulation of cuticle pigmentation|up regulation of cuticle pigmentation|up-regulation of cuticle pigmentation|upregulation of cuticle pigmentation http://purl.obolibrary.org/obo/GO_0048081 GO:0048080 biolink:BiologicalProcess negative regulation of cuticle pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. go.json down regulation of cuticle pigmentation|down-regulation of cuticle pigmentation|downregulation of cuticle pigmentation|inhibition of cuticle pigmentation http://purl.obolibrary.org/obo/GO_0048080 GO:0097006 biolink:BiologicalProcess regulation of plasma lipoprotein particle levels Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. go.json plasma lipoprotein particle homeostasis http://purl.obolibrary.org/obo/GO_0097006 GO:0097005 biolink:MolecularActivity adipokinetic hormone receptor binding Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. go.json AKH receptor binding http://purl.obolibrary.org/obo/GO_0097005 GO:0097008 biolink:MolecularActivity (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone. MetaCyc:RXN-8619 go.json (3E)-4,8-dimethylnona-1,3,7-triene synthase activity|DNMT synthase activity http://purl.obolibrary.org/obo/GO_0097008 GO:0097007 biolink:MolecularActivity 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone. MetaCyc:RXN-8620|RHEA:13545 go.json 4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity|TMTT synthase activity http://purl.obolibrary.org/obo/GO_0097007 GO:0048089 biolink:BiologicalProcess regulation of female pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females. go.json http://purl.obolibrary.org/obo/GO_0048089 GO:0048088 biolink:BiologicalProcess regulation of male pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males. go.json http://purl.obolibrary.org/obo/GO_0048088 GO:0048087 biolink:BiologicalProcess positive regulation of developmental pigmentation Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. go.json activation of developmental pigmentation|stimulation of developmental pigmentation|up regulation of developmental pigmentation|up-regulation of developmental pigmentation|upregulation of developmental pigmentation http://purl.obolibrary.org/obo/GO_0048087 GO:0048086 biolink:BiologicalProcess negative regulation of developmental pigmentation Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. go.json down regulation of developmental pigmentation|down-regulation of developmental pigmentation|downregulation of developmental pigmentation|inhibition of pigmentation http://purl.obolibrary.org/obo/GO_0048086 GO:0048085 biolink:BiologicalProcess adult chitin-containing cuticle pigmentation Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster. go.json adult cuticle pigmentation http://purl.obolibrary.org/obo/GO_0048085 GO:0048084 biolink:BiologicalProcess positive regulation of adult chitin-containing cuticle pigmentation Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. go.json activation of adult chitin-containing cuticle pigmentation|stimulation of adult chitin-containing cuticle pigmentation|up regulation of adult chitin-containing cuticle pigmentation|up-regulation of adult chitin-containing cuticle pigmentation|upregulation of adult chitin-containing cuticle pigmentation http://purl.obolibrary.org/obo/GO_0048084 GO:0048083 biolink:BiologicalProcess negative regulation of adult chitin-containing cuticle pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. go.json down regulation of adult chitin-containing cuticle pigmentation|down-regulation of adult chitin-containing cuticle pigmentation|downregulation of adult chitin-containing cuticle pigmentation|inhibition of adult chitin-containing cuticle pigmentation http://purl.obolibrary.org/obo/GO_0048083 GO:0014706 biolink:BiologicalProcess striated muscle tissue development The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. go.json http://purl.obolibrary.org/obo/GO_0014706 GO:0014705 biolink:CellularComponent C zone A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin. go.json http://purl.obolibrary.org/obo/GO_0014705 GO:1903249 biolink:BiologicalProcess negative regulation of citrulline biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process. go.json down regulation of citrulline anabolism|down regulation of citrulline biosynthesis|down regulation of citrulline biosynthetic process|down regulation of citrulline formation|down regulation of citrulline synthesis|down-regulation of citrulline anabolism|down-regulation of citrulline biosynthesis|down-regulation of citrulline biosynthetic process|down-regulation of citrulline formation|down-regulation of citrulline synthesis|downregulation of citrulline anabolism|downregulation of citrulline biosynthesis|downregulation of citrulline biosynthetic process|downregulation of citrulline formation|downregulation of citrulline synthesis|inhibition of citrulline anabolism|inhibition of citrulline biosynthesis|inhibition of citrulline biosynthetic process|inhibition of citrulline formation|inhibition of citrulline synthesis|negative regulation of citrulline anabolism|negative regulation of citrulline biosynthesis|negative regulation of citrulline formation|negative regulation of citrulline synthesis http://purl.obolibrary.org/obo/GO_1903249 GO:0014704 biolink:CellularComponent intercalated disc A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. Wikipedia:Intercalated_disc go.json intercalated disk http://purl.obolibrary.org/obo/GO_0014704 GO:1903248 biolink:BiologicalProcess regulation of citrulline biosynthetic process Any process that modulates the frequency, rate or extent of citrulline biosynthetic process. go.json regulation of citrulline anabolism|regulation of citrulline biosynthesis|regulation of citrulline formation|regulation of citrulline synthesis http://purl.obolibrary.org/obo/GO_1903248 GO:0014703 biolink:BiologicalProcess oscillatory muscle contraction A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation. go.json http://purl.obolibrary.org/obo/GO_0014703 GO:1903247 biolink:BiologicalProcess obsolete positive regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate OBSOLETE. Any process that activates or increases the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate. go.json activation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|activation of If activation by beta-adrenergic receptor signaling pathway|activation of activation of funny current by beta-adrenergic receptor signaling pathway|activation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|activation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|activation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|activation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|positive regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|positive regulation of If activation by beta-adrenergic receptor signaling pathway|positive regulation of activation of funny current by beta-adrenergic receptor signaling pathway|positive regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|positive regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|positive regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|up regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|up regulation of If activation by beta-adrenergic receptor signaling pathway|up regulation of activation of funny current by beta-adrenergic receptor signaling pathway|up regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|up regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|up regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|up regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|up-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|up-regulation of If activation by beta-adrenergic receptor signaling pathway|up-regulation of activation of funny current by beta-adrenergic receptor signaling pathway|up-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|up-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|up-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|up-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|upregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|upregulation of If activation by beta-adrenergic receptor signaling pathway|upregulation of activation of funny current by beta-adrenergic receptor signaling pathway|upregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|upregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|upregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|upregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate True http://purl.obolibrary.org/obo/GO_1903247 GO:1903246 biolink:BiologicalProcess obsolete negative regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate. go.json down regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|down regulation of If activation by beta-adrenergic receptor signaling pathway|down regulation of activation of funny current by beta-adrenergic receptor signaling pathway|down regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|down regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|down regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|down regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|down-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|down-regulation of If activation by beta-adrenergic receptor signaling pathway|down-regulation of activation of funny current by beta-adrenergic receptor signaling pathway|down-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|down-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|down-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|down-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|downregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|downregulation of If activation by beta-adrenergic receptor signaling pathway|downregulation of activation of funny current by beta-adrenergic receptor signaling pathway|downregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|downregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate|downregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|downregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|inhibition of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|inhibition of If activation by beta-adrenergic receptor signaling pathway|inhibition of activation of funny current by beta-adrenergic receptor signaling pathway|inhibition of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|inhibition of adrenergic receptor signaling pathway involved in positive regulation of heart rate|inhibition of adrenergic receptor signalling pathway involved in positive regulation of heart rate|inhibition of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|negative regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|negative regulation of If activation by beta-adrenergic receptor signaling pathway|negative regulation of activation of funny current by beta-adrenergic receptor signaling pathway|negative regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|negative regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|negative regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate True http://purl.obolibrary.org/obo/GO_1903246 GO:0014709 biolink:BiologicalProcess positive regulation of somitomeric trunk muscle development Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. go.json http://purl.obolibrary.org/obo/GO_0014709 GO:1903245 biolink:BiologicalProcess obsolete regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate OBSOLETE. Any process that modulates the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate. go.json regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|regulation of If activation by beta-adrenergic receptor signaling pathway|regulation of activation of funny current by beta-adrenergic receptor signaling pathway|regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate|regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate True http://purl.obolibrary.org/obo/GO_1903245 GO:0014708 biolink:BiologicalProcess regulation of somitomeric trunk muscle development Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development. go.json http://purl.obolibrary.org/obo/GO_0014708 GO:1903244 biolink:BiologicalProcess positive regulation of cardiac muscle hypertrophy in response to stress Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. go.json activation of cardiac muscle hypertrophy in response to stress|up regulation of cardiac muscle hypertrophy in response to stress|up-regulation of cardiac muscle hypertrophy in response to stress|upregulation of cardiac muscle hypertrophy in response to stress http://purl.obolibrary.org/obo/GO_1903244 GO:0014707 biolink:BiologicalProcess branchiomeric skeletal muscle development The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish. go.json http://purl.obolibrary.org/obo/GO_0014707 GO:1903254 biolink:BiologicalProcess hercynylselenocysteine metabolic process The chemical reactions and pathways involving hercynylselenocysteine. go.json hercynylselenocysteine metabolism http://purl.obolibrary.org/obo/GO_1903254 GO:1903253 biolink:BiologicalProcess hercynylcysteine sulfoxide biosynthetic process The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide. go.json hercynylcysteine sulfoxide anabolism|hercynylcysteine sulfoxide biosynthesis|hercynylcysteine sulfoxide formation|hercynylcysteine sulfoxide synthesis http://purl.obolibrary.org/obo/GO_1903253 GO:1903252 biolink:BiologicalProcess hercynylcysteine sulfoxide metabolic process The chemical reactions and pathways involving hercynylcysteine sulfoxide. go.json hercynylcysteine sulfoxide metabolism http://purl.obolibrary.org/obo/GO_1903252 GO:1903251 biolink:BiologicalProcess multi-ciliated epithelial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. go.json multiciliate cell differentiation http://purl.obolibrary.org/obo/GO_1903251 GO:0014702 biolink:CellularComponent free sarcoplasmic reticulum membrane The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane. go.json http://purl.obolibrary.org/obo/GO_0014702 GO:1903250 biolink:BiologicalProcess positive regulation of citrulline biosynthetic process Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process. go.json activation of citrulline anabolism|activation of citrulline biosynthesis|activation of citrulline biosynthetic process|activation of citrulline formation|activation of citrulline synthesis|positive regulation of citrulline anabolism|positive regulation of citrulline biosynthesis|positive regulation of citrulline formation|positive regulation of citrulline synthesis|up regulation of citrulline anabolism|up regulation of citrulline biosynthesis|up regulation of citrulline biosynthetic process|up regulation of citrulline formation|up regulation of citrulline synthesis|up-regulation of citrulline anabolism|up-regulation of citrulline biosynthesis|up-regulation of citrulline biosynthetic process|up-regulation of citrulline formation|up-regulation of citrulline synthesis|upregulation of citrulline anabolism|upregulation of citrulline biosynthesis|upregulation of citrulline biosynthetic process|upregulation of citrulline formation|upregulation of citrulline synthesis http://purl.obolibrary.org/obo/GO_1903250 GO:0014701 biolink:CellularComponent junctional sarcoplasmic reticulum membrane The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane. go.json http://purl.obolibrary.org/obo/GO_0014701 GO:0048093 biolink:BiologicalProcess positive regulation of male pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males. go.json activation of male pigmentation|stimulation of male pigmentation|up regulation of male pigmentation|up-regulation of male pigmentation|upregulation of male pigmentation http://purl.obolibrary.org/obo/GO_0048093 GO:0048092 biolink:BiologicalProcess negative regulation of male pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males. go.json down regulation of male pigmentation|down-regulation of male pigmentation|downregulation of male pigmentation|inhibition of male pigmentation http://purl.obolibrary.org/obo/GO_0048092 GO:0048091 biolink:BiologicalProcess positive regulation of female pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females. go.json activation of female pigmentation|stimulation of female pigmentation|up regulation of female pigmentation|up-regulation of female pigmentation|upregulation of female pigmentation http://purl.obolibrary.org/obo/GO_0048091 GO:0048090 biolink:BiologicalProcess negative regulation of female pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females. go.json down regulation of female pigmentation|down-regulation of female pigmentation|downregulation of female pigmentation|inhibition of female pigmentation http://purl.obolibrary.org/obo/GO_0048090 GO:0048099 biolink:BiologicalProcess anterior/posterior lineage restriction, imaginal disc Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment. go.json http://purl.obolibrary.org/obo/GO_0048099 GO:0048098 biolink:BiologicalProcess antennal joint development The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments. go.json http://purl.obolibrary.org/obo/GO_0048098 GO:0048097 biolink:BiologicalProcess obsolete long-term maintenance of gene activation OBSOLETE. Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term. go.json True http://purl.obolibrary.org/obo/GO_0048097 GO:0048096 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048096 GO:0048095 biolink:BiologicalProcess female pigmentation Establishment of a pattern of pigment in females. go.json http://purl.obolibrary.org/obo/GO_0048095 GO:0048094 biolink:BiologicalProcess male pigmentation Establishment of a pattern of pigment in males. go.json http://purl.obolibrary.org/obo/GO_0048094 GO:0014717 biolink:BiologicalProcess regulation of satellite cell activation involved in skeletal muscle regeneration Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. go.json http://purl.obolibrary.org/obo/GO_0014717 GO:0014716 biolink:BiologicalProcess skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt. go.json satellite cell asymmetric division involved in skeletal muscle regeneration http://purl.obolibrary.org/obo/GO_0014716 GO:0014715 biolink:BiologicalProcess myoblast fate commitment in trunk The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014715 GO:0014714 biolink:BiologicalProcess myoblast fate commitment in head The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014714 GO:1903259 biolink:BiologicalProcess exon-exon junction complex disassembly The disaggregation of an exon-exon junction complex into its constituent components. go.json EJC disassembly http://purl.obolibrary.org/obo/GO_1903259 GO:1903258 biolink:BiologicalProcess sorbose import across plasma membrane The process in which sorbose is transported from outside of a cell, across the plasma membrane and into the cytosol. go.json sorbose import into cell http://purl.obolibrary.org/obo/GO_1903258 GO:1903257 biolink:BiologicalProcess selenoneine biosynthetic process The chemical reactions and pathways resulting in the formation of selenoneine. go.json L-selenoneine biosynthetic process|selenoneine anabolism|selenoneine biosynthesis|selenoneine formation|selenoneine synthesis http://purl.obolibrary.org/obo/GO_1903257 GO:1903256 biolink:BiologicalProcess selenoneine metabolic process The chemical reactions and pathways involving selenoneine. go.json L-selenoneine metabolic process|selenoneine metabolism http://purl.obolibrary.org/obo/GO_1903256 GO:0014719 biolink:BiologicalProcess skeletal muscle satellite cell activation The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. go.json http://purl.obolibrary.org/obo/GO_0014719 GO:0014718 biolink:BiologicalProcess positive regulation of satellite cell activation involved in skeletal muscle regeneration Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. go.json http://purl.obolibrary.org/obo/GO_0014718 GO:1903255 biolink:BiologicalProcess hercynylselenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of hercynylselenocysteine. go.json hercynylselenocysteine anabolism|hercynylselenocysteine biosynthesis|hercynylselenocysteine formation|hercynylselenocysteine synthesis http://purl.obolibrary.org/obo/GO_1903255 GO:1903265 biolink:BiologicalProcess positive regulation of tumor necrosis factor-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. go.json activation of TNF-alpha-mediated signaling pathway|activation of adipocytokine signaling pathway|activation of tumor necrosis factor alpha-mediated signaling pathway|activation of tumor necrosis factor-mediated signaling pathway|activation of tumor necrosis factor-mediated signalling pathway|positive regulation of TNF-alpha-mediated signaling pathway|positive regulation of adipocytokine signaling pathway|positive regulation of tumor necrosis factor alpha-mediated signaling pathway|positive regulation of tumor necrosis factor-mediated signalling pathway|up regulation of TNF-alpha-mediated signaling pathway|up regulation of adipocytokine signaling pathway|up regulation of tumor necrosis factor alpha-mediated signaling pathway|up regulation of tumor necrosis factor-mediated signaling pathway|up regulation of tumor necrosis factor-mediated signalling pathway|up-regulation of TNF-alpha-mediated signaling pathway|up-regulation of adipocytokine signaling pathway|up-regulation of tumor necrosis factor alpha-mediated signaling pathway|up-regulation of tumor necrosis factor-mediated signaling pathway|up-regulation of tumor necrosis factor-mediated signalling pathway|upregulation of TNF-alpha-mediated signaling pathway|upregulation of adipocytokine signaling pathway|upregulation of tumor necrosis factor alpha-mediated signaling pathway|upregulation of tumor necrosis factor-mediated signaling pathway|upregulation of tumor necrosis factor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1903265 GO:1903264 biolink:MolecularActivity nitrate reductase activity involved in anaerobic electron transport chain Any nitrate reductase activity that is involved in anaerobic electron transport chain. go.json nitrate reductase (acceptor) involved in anaerobic electron transport chain|nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain|nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain|respiratory nitrate reductase activity involved in anaerobic electron transport chain http://purl.obolibrary.org/obo/GO_1903264 GO:1903263 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903263 GO:1903262 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903262 GO:0014713 biolink:BiologicalProcess negative regulation of branchiomeric skeletal muscle development Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0014713 GO:1903261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903261 GO:1903260 biolink:BiologicalProcess protein localization to mating projection tip A process in which a protein is transported to, or maintained in, a location within a mating projection tip. go.json protein localisation in mating projection tip|protein localisation to mating projection tip|protein localization in mating projection tip|protein localization to conjugation tube tip|protein localization to shmoo tip http://purl.obolibrary.org/obo/GO_1903260 GO:0014712 biolink:BiologicalProcess positive regulation of branchiomeric skeletal muscle development Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0014712 GO:0014711 biolink:BiologicalProcess regulation of branchiomeric skeletal muscle development Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0014711 GO:0014710 biolink:BiologicalProcess negative regulation of somitomeric trunk muscle development Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. go.json http://purl.obolibrary.org/obo/GO_0014710 GO:0097035 biolink:BiologicalProcess regulation of membrane lipid distribution Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. go.json http://purl.obolibrary.org/obo/GO_0097035 GO:0097034 biolink:BiologicalProcess obsolete mitochondrial respiratory chain complex IV biogenesis OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. go.json mitochondrial cytochrome c oxidase complex biogenesis True http://purl.obolibrary.org/obo/GO_0097034 GO:0097037 biolink:BiologicalProcess heme export The directed movement of heme out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0097037 GO:0097036 biolink:BiologicalProcess regulation of plasma membrane sterol distribution Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0097036 GO:0097031 biolink:BiologicalProcess obsolete mitochondrial respiratory chain complex I biogenesis OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. go.json True http://purl.obolibrary.org/obo/GO_0097031 GO:0097030 biolink:MolecularActivity CENP-A containing nucleosome binding Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). go.json centromere-specific nucleosome binding|centromeric nucleosome binding http://purl.obolibrary.org/obo/GO_0097030 GO:0097033 biolink:BiologicalProcess obsolete mitochondrial respiratory chain complex III biogenesis OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. go.json mitochondrial cytochrome bc(1) complex biogenesis True http://purl.obolibrary.org/obo/GO_0097033 GO:0097032 biolink:BiologicalProcess obsolete mitochondrial respiratory chain complex II biogenesis OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex II, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. go.json True http://purl.obolibrary.org/obo/GO_0097032 GO:1903269 biolink:CellularComponent ornithine carbamoyltransferase inhibitor complex A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity. go.json OTC-ARGI complex|ornithine carbamoyltransferase arginase complex http://purl.obolibrary.org/obo/GO_1903269 GO:1903268 biolink:BiologicalProcess positive regulation of ornithine catabolic process Any process that activates or increases the frequency, rate or extent of ornithine catabolic process. go.json activation of ornithine breakdown|activation of ornithine catabolic process|activation of ornithine catabolism|activation of ornithine degradation|positive regulation of ornithine breakdown|positive regulation of ornithine catabolism|positive regulation of ornithine degradation|up regulation of ornithine breakdown|up regulation of ornithine catabolic process|up regulation of ornithine catabolism|up regulation of ornithine degradation|up-regulation of ornithine breakdown|up-regulation of ornithine catabolic process|up-regulation of ornithine catabolism|up-regulation of ornithine degradation|upregulation of ornithine breakdown|upregulation of ornithine catabolic process|upregulation of ornithine catabolism|upregulation of ornithine degradation http://purl.obolibrary.org/obo/GO_1903268 GO:1903267 biolink:BiologicalProcess negative regulation of ornithine catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of ornithine catabolic process. go.json down regulation of ornithine breakdown|down regulation of ornithine catabolic process|down regulation of ornithine catabolism|down regulation of ornithine degradation|down-regulation of ornithine breakdown|down-regulation of ornithine catabolic process|down-regulation of ornithine catabolism|down-regulation of ornithine degradation|downregulation of ornithine breakdown|downregulation of ornithine catabolic process|downregulation of ornithine catabolism|downregulation of ornithine degradation|inhibition of ornithine breakdown|inhibition of ornithine catabolic process|inhibition of ornithine catabolism|inhibition of ornithine degradation|negative regulation of ornithine breakdown|negative regulation of ornithine catabolism|negative regulation of ornithine degradation http://purl.obolibrary.org/obo/GO_1903267 GO:1903266 biolink:BiologicalProcess regulation of ornithine catabolic process Any process that modulates the frequency, rate or extent of ornithine catabolic process. go.json regulation of ornithine breakdown|regulation of ornithine catabolism|regulation of ornithine degradation http://purl.obolibrary.org/obo/GO_1903266 GO:1903276 biolink:BiologicalProcess regulation of sodium ion export across plasma membrane Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane. go.json regulation of sodium export|regulation of sodium ion export|regulation of sodium ion export from cell http://purl.obolibrary.org/obo/GO_1903276 GO:1903275 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903275 GO:1903274 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903274 GO:1903273 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903273 GO:1903272 biolink:BiologicalProcess positive regulation of cytoplasmic translational elongation through polyproline stretches Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches. go.json activation of cytoplasmic translational elongation through polyproline stretches|up regulation of cytoplasmic translational elongation through polyproline stretches|up-regulation of cytoplasmic translational elongation through polyproline stretches|upregulation of cytoplasmic translational elongation through polyproline stretches http://purl.obolibrary.org/obo/GO_1903272 GO:1903271 biolink:BiologicalProcess negative regulation of cytoplasmic translational elongation through polyproline stretches Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches. go.json down regulation of cytoplasmic translational elongation through polyproline stretches|down-regulation of cytoplasmic translational elongation through polyproline stretches|downregulation of cytoplasmic translational elongation through polyproline stretches|inhibition of cytoplasmic translational elongation through polyproline stretches http://purl.obolibrary.org/obo/GO_1903271 GO:1903270 biolink:BiologicalProcess regulation of cytoplasmic translational elongation through polyproline stretches Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches. go.json http://purl.obolibrary.org/obo/GO_1903270 GO:0097039 biolink:BiologicalProcess protein linear polyubiquitination A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein. go.json M1 linkage http://purl.obolibrary.org/obo/GO_0097039 GO:0097038 biolink:CellularComponent perinuclear endoplasmic reticulum The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. go.json perinuclear ER http://purl.obolibrary.org/obo/GO_0097038 GO:0097046 biolink:BiologicalProcess replication fork progression beyond termination site Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks. go.json http://purl.obolibrary.org/obo/GO_0097046 GO:0097045 biolink:BiologicalProcess phosphatidylserine exposure on blood platelet A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system. go.json http://purl.obolibrary.org/obo/GO_0097045 GO:0097048 biolink:BiologicalProcess dendritic cell apoptotic process Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. go.json dendritic cell apoptosis http://purl.obolibrary.org/obo/GO_0097048 GO:0097047 biolink:CellularComponent DNA replication termination region A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks. go.json TER http://purl.obolibrary.org/obo/GO_0097047 GO:0097042 biolink:CellularComponent obsolete extrinsic component of fungal-type vacuolar membrane OBSOLETE. The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to fungal-type vacuolar membrane True http://purl.obolibrary.org/obo/GO_0097042 GO:0097041 biolink:BiologicalProcess phenolic phthiocerol biosynthetic process The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position. go.json phenolic phthiocerol anabolism|phenolic phthiocerol biosynthesis|phenolic phthiocerol formation|phenolic phthiocerol synthesis|phenolphthiocerol biosynthesis http://purl.obolibrary.org/obo/GO_0097041 GO:0097044 biolink:BiologicalProcess obsolete histone H3-K56 acetylation in response to DNA damage OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell. go.json True http://purl.obolibrary.org/obo/GO_0097044 GO:0097043 biolink:BiologicalProcess histone H3-K56 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone. go.json http://purl.obolibrary.org/obo/GO_0097043 gocheck_do_not_annotate GO:0097040 biolink:BiologicalProcess phthiocerol biosynthetic process The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents. go.json phthiocerol anabolism|phthiocerol biosynthesis|phthiocerol formation|phthiocerol synthesis http://purl.obolibrary.org/obo/GO_0097040 GO:1903279 biolink:BiologicalProcess regulation of calcium:sodium antiporter activity Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity. go.json regulation of mitochondrial sodium/calcium ion exchange|regulation of sodium/calcium exchanger|regulation of sodium:calcium exchange http://purl.obolibrary.org/obo/GO_1903279 gocheck_do_not_annotate GO:1903278 biolink:BiologicalProcess positive regulation of sodium ion export across plasma membrane Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane. go.json activation of sodium export|activation of sodium ion export|activation of sodium ion export from cell|positive regulation of sodium export|positive regulation of sodium ion export|positive regulation of sodium ion export from cell|up regulation of sodium export|up regulation of sodium ion export|up regulation of sodium ion export from cell|up-regulation of sodium export|up-regulation of sodium ion export|up-regulation of sodium ion export from cell|upregulation of sodium export|upregulation of sodium ion export|upregulation of sodium ion export from cell http://purl.obolibrary.org/obo/GO_1903278 GO:1903277 biolink:BiologicalProcess negative regulation of sodium ion export across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane. go.json down regulation of sodium export|down regulation of sodium ion export|down regulation of sodium ion export from cell|down-regulation of sodium export|down-regulation of sodium ion export|down-regulation of sodium ion export from cell|downregulation of sodium export|downregulation of sodium ion export|downregulation of sodium ion export from cell|inhibition of sodium export|inhibition of sodium ion export|inhibition of sodium ion export from cell|negative regulation of sodium export|negative regulation of sodium ion export|negative regulation of sodium ion export from cell http://purl.obolibrary.org/obo/GO_1903277 GO:1903287 biolink:BiologicalProcess negative regulation of potassium ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import across the plasma membrane. go.json down regulation of potassium import|down regulation of potassium ion import|down regulation of potassium ion uptake|down-regulation of potassium import|down-regulation of potassium ion import|down-regulation of potassium ion uptake|downregulation of potassium import|downregulation of potassium ion import|downregulation of potassium ion uptake|inhibition of potassium import|inhibition of potassium ion import|inhibition of potassium ion uptake|negative regulation of potassium import|negative regulation of potassium ion import|negative regulation of potassium ion uptake http://purl.obolibrary.org/obo/GO_1903287 GO:1903286 biolink:BiologicalProcess regulation of potassium ion import Any process that modulates the frequency, rate or extent of potassium ion import. go.json regulation of potassium import|regulation of potassium ion uptake http://purl.obolibrary.org/obo/GO_1903286 GO:1903285 biolink:BiologicalProcess positive regulation of hydrogen peroxide catabolic process Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process. go.json activation of H2O2 catabolic process|activation of H2O2 scavenging|activation of detoxification of H2O2|activation of detoxification of hydrogen peroxide|activation of hydrogen peroxide breakdown|activation of hydrogen peroxide catabolic process|activation of hydrogen peroxide catabolism|activation of hydrogen peroxide degradation|activation of hydrogen peroxide removal|activation of hydrogen peroxide scavenging|positive regulation of H2O2 catabolic process|positive regulation of H2O2 scavenging|positive regulation of detoxification of H2O2|positive regulation of detoxification of hydrogen peroxide|positive regulation of hydrogen peroxide breakdown|positive regulation of hydrogen peroxide catabolism|positive regulation of hydrogen peroxide degradation|positive regulation of hydrogen peroxide removal|positive regulation of hydrogen peroxide scavenging|up regulation of H2O2 catabolic process|up regulation of H2O2 scavenging|up regulation of detoxification of H2O2|up regulation of detoxification of hydrogen peroxide|up regulation of hydrogen peroxide breakdown|up regulation of hydrogen peroxide catabolic process|up regulation of hydrogen peroxide catabolism|up regulation of hydrogen peroxide degradation|up regulation of hydrogen peroxide removal|up regulation of hydrogen peroxide scavenging|up-regulation of H2O2 catabolic process|up-regulation of H2O2 scavenging|up-regulation of detoxification of H2O2|up-regulation of detoxification of hydrogen peroxide|up-regulation of hydrogen peroxide breakdown|up-regulation of hydrogen peroxide catabolic process|up-regulation of hydrogen peroxide catabolism|up-regulation of hydrogen peroxide degradation|up-regulation of hydrogen peroxide removal|up-regulation of hydrogen peroxide scavenging|upregulation of H2O2 catabolic process|upregulation of H2O2 scavenging|upregulation of detoxification of H2O2|upregulation of detoxification of hydrogen peroxide|upregulation of hydrogen peroxide breakdown|upregulation of hydrogen peroxide catabolic process|upregulation of hydrogen peroxide catabolism|upregulation of hydrogen peroxide degradation|upregulation of hydrogen peroxide removal|upregulation of hydrogen peroxide scavenging http://purl.obolibrary.org/obo/GO_1903285 GO:1903284 biolink:BiologicalProcess positive regulation of glutathione peroxidase activity Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity. go.json activation of GSH peroxidase activity|activation of glutathione peroxidase activity|activation of glutathione:hydrogen-peroxide oxidoreductase activity|activation of non-selenium glutathione peroxidase activity|activation of reduced glutathione peroxidase activity|activation of selenium-glutathione peroxidase activity|enhancement of GPX activity|positive regulation of GSH peroxidase activity|positive regulation of glutathione:hydrogen-peroxide oxidoreductase activity|positive regulation of non-selenium glutathione peroxidase activity|positive regulation of reduced glutathione peroxidase activity|positive regulation of selenium-glutathione peroxidase activity|up regulation of GSH peroxidase activity|up regulation of glutathione peroxidase activity|up regulation of glutathione:hydrogen-peroxide oxidoreductase activity|up regulation of non-selenium glutathione peroxidase activity|up regulation of reduced glutathione peroxidase activity|up regulation of selenium-glutathione peroxidase activity|up-regulation of GSH peroxidase activity|up-regulation of glutathione peroxidase activity|up-regulation of glutathione:hydrogen-peroxide oxidoreductase activity|up-regulation of non-selenium glutathione peroxidase activity|up-regulation of reduced glutathione peroxidase activity|up-regulation of selenium-glutathione peroxidase activity|upregulation of GSH peroxidase activity|upregulation of glutathione peroxidase activity|upregulation of glutathione:hydrogen-peroxide oxidoreductase activity|upregulation of non-selenium glutathione peroxidase activity|upregulation of reduced glutathione peroxidase activity|upregulation of selenium-glutathione peroxidase activity http://purl.obolibrary.org/obo/GO_1903284 gocheck_do_not_annotate GO:1903283 biolink:BiologicalProcess negative regulation of glutathione peroxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity. go.json down regulation of GSH peroxidase activity|down regulation of glutathione peroxidase activity|down regulation of glutathione:hydrogen-peroxide oxidoreductase activity|down regulation of non-selenium glutathione peroxidase activity|down regulation of reduced glutathione peroxidase activity|down regulation of selenium-glutathione peroxidase activity|down-regulation of GSH peroxidase activity|down-regulation of glutathione peroxidase activity|down-regulation of glutathione:hydrogen-peroxide oxidoreductase activity|down-regulation of non-selenium glutathione peroxidase activity|down-regulation of reduced glutathione peroxidase activity|down-regulation of selenium-glutathione peroxidase activity|downregulation of GSH peroxidase activity|downregulation of glutathione peroxidase activity|downregulation of glutathione:hydrogen-peroxide oxidoreductase activity|downregulation of non-selenium glutathione peroxidase activity|downregulation of reduced glutathione peroxidase activity|downregulation of selenium-glutathione peroxidase activity|inhibition of GSH peroxidase activity|inhibition of glutathione peroxidase activity|inhibition of glutathione:hydrogen-peroxide oxidoreductase activity|inhibition of non-selenium glutathione peroxidase activity|inhibition of reduced glutathione peroxidase activity|inhibition of selenium-glutathione peroxidase activity|negative regulation of GSH peroxidase activity|negative regulation of glutathione:hydrogen-peroxide oxidoreductase activity|negative regulation of non-selenium glutathione peroxidase activity|negative regulation of reduced glutathione peroxidase activity|negative regulation of selenium-glutathione peroxidase activity http://purl.obolibrary.org/obo/GO_1903283 gocheck_do_not_annotate GO:1903282 biolink:BiologicalProcess regulation of glutathione peroxidase activity Any process that modulates the frequency, rate or extent of glutathione peroxidase activity. go.json regulation of GSH peroxidase activity|regulation of glutathione:hydrogen-peroxide oxidoreductase activity|regulation of non-selenium glutathione peroxidase activity|regulation of reduced glutathione peroxidase activity|regulation of selenium-glutathione peroxidase activity http://purl.obolibrary.org/obo/GO_1903282 gocheck_do_not_annotate GO:1903281 biolink:BiologicalProcess positive regulation of calcium:sodium antiporter activity Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity. go.json activation of calcium:sodium antiporter activity|activation of mitochondrial sodium/calcium ion exchange|activation of sodium/calcium exchanger|activation of sodium:calcium exchange|positive regulation of mitochondrial sodium/calcium ion exchange|positive regulation of sodium/calcium exchanger|positive regulation of sodium:calcium exchange|up regulation of calcium:sodium antiporter activity|up regulation of mitochondrial sodium/calcium ion exchange|up regulation of sodium/calcium exchanger|up regulation of sodium:calcium exchange|up-regulation of calcium:sodium antiporter activity|up-regulation of mitochondrial sodium/calcium ion exchange|up-regulation of sodium/calcium exchanger|up-regulation of sodium:calcium exchange|upregulation of calcium:sodium antiporter activity|upregulation of mitochondrial sodium/calcium ion exchange|upregulation of sodium/calcium exchanger|upregulation of sodium:calcium exchange http://purl.obolibrary.org/obo/GO_1903281 gocheck_do_not_annotate GO:1903280 biolink:BiologicalProcess negative regulation of calcium:sodium antiporter activity Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity. go.json down regulation of calcium:sodium antiporter activity|down regulation of mitochondrial sodium/calcium ion exchange|down regulation of sodium/calcium exchanger|down regulation of sodium:calcium exchange|down-regulation of calcium:sodium antiporter activity|down-regulation of mitochondrial sodium/calcium ion exchange|down-regulation of sodium/calcium exchanger|down-regulation of sodium:calcium exchange|downregulation of calcium:sodium antiporter activity|downregulation of mitochondrial sodium/calcium ion exchange|downregulation of sodium/calcium exchanger|downregulation of sodium:calcium exchange|inhibition of calcium:sodium antiporter activity|inhibition of mitochondrial sodium/calcium ion exchange|inhibition of sodium/calcium exchanger|inhibition of sodium:calcium exchange|negative regulation of mitochondrial sodium/calcium ion exchange|negative regulation of sodium/calcium exchanger|negative regulation of sodium:calcium exchange http://purl.obolibrary.org/obo/GO_1903280 gocheck_do_not_annotate GO:0097049 biolink:BiologicalProcess motor neuron apoptotic process Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. go.json motoneuron apoptosis|motor neuron apoptosis http://purl.obolibrary.org/obo/GO_0097049 GO:0097013 biolink:CellularComponent phagocytic vesicle lumen The volume enclosed by the membrane of a phagocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0097013 GO:0097012 biolink:BiologicalProcess response to granulocyte macrophage colony-stimulating factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. go.json response to GM-CSF|response to granulocyte macrophage colony-stimulating factor stimulus http://purl.obolibrary.org/obo/GO_0097012 GO:0097015 biolink:CellularComponent obsolete bacterial-type flagellar cytoplasm OBSOLETE. All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum. go.json bacterial-type flagellum cytoplasm True http://purl.obolibrary.org/obo/GO_0097015 GO:0097014 biolink:CellularComponent ciliary plasm All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. go.json cilial cytoplasm|ciliary cytoplasm|cilium cytoplasm|cilium plasm|microtubule-based flagellar cytoplasm|microtubule-based flagellar matrix|microtubule-based flagellum cytoplasm|microtubule-based flagellum matrix http://purl.obolibrary.org/obo/GO_0097014 GO:0097011 biolink:BiologicalProcess cellular response to granulocyte macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. go.json cellular response to GM-CSF stimulus http://purl.obolibrary.org/obo/GO_0097011 GO:0097010 biolink:BiologicalProcess eukaryotic translation initiation factor 4F complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex. go.json eIF-4F assembly|eIF4F assembly http://purl.obolibrary.org/obo/GO_0097010 GO:1903289 biolink:BiologicalProcess obsolete regulation of ATP catabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of ATP catabolic process. go.json regulation of ATP breakdown|regulation of ATP catabolism|regulation of ATP degradation|regulation of ATP hydrolysis True http://purl.obolibrary.org/obo/GO_1903289 GO:1903288 biolink:BiologicalProcess positive regulation of potassium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane. go.json activation of potassium import|activation of potassium ion import|activation of potassium ion uptake|positive regulation of potassium import|positive regulation of potassium ion import|positive regulation of potassium ion uptake|up regulation of potassium import|up regulation of potassium ion import|up regulation of potassium ion uptake|up-regulation of potassium import|up-regulation of potassium ion import|up-regulation of potassium ion uptake|upregulation of potassium import|upregulation of potassium ion import|upregulation of potassium ion uptake http://purl.obolibrary.org/obo/GO_1903288 GO:1903298 biolink:BiologicalProcess negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. go.json down regulation of intrinsic apoptotic signaling pathway in response to hypoxia|down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia|downregulation of intrinsic apoptotic signaling pathway in response to hypoxia|inhibition of intrinsic apoptotic signaling pathway in response to hypoxia|negative regulation of hypoxia-induced apoptosis|negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia|protection against hypoxia-induced apoptosis http://purl.obolibrary.org/obo/GO_1903298 GO:1903297 biolink:BiologicalProcess regulation of hypoxia-induced intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. go.json regulation of hypoxia-induced apoptosis|regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway in response to hypoxia http://purl.obolibrary.org/obo/GO_1903297 GO:1903296 biolink:BiologicalProcess positive regulation of glutamate secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter. go.json activation of glutamate secretion, neurotransmission|up regulation of glutamate secretion, neurotransmission|up-regulation of glutamate secretion, neurotransmission|upregulation of glutamate secretion, neurotransmission http://purl.obolibrary.org/obo/GO_1903296 GO:1903295 biolink:BiologicalProcess negative regulation of glutamate secretion, neurotransmission Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission. go.json down regulation of glutamate secretion, neurotransmission|down-regulation of glutamate secretion, neurotransmission|downregulation of glutamate secretion, neurotransmission|inhibition of glutamate secretion, neurotransmission http://purl.obolibrary.org/obo/GO_1903295 GO:1903294 biolink:BiologicalProcess regulation of glutamate secretion, neurotransmission Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission. go.json http://purl.obolibrary.org/obo/GO_1903294 GO:1903293 biolink:CellularComponent phosphatase complex A protein complex which is capable of phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_1903293 GO:1903292 biolink:BiologicalProcess protein localization to Golgi membrane A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. go.json protein localisation in Golgi membrane|protein localisation to Golgi membrane|protein localization in Golgi membrane http://purl.obolibrary.org/obo/GO_1903292 GO:1903291 biolink:BiologicalProcess obsolete positive regulation of ATP catabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP catabolic process. go.json activation of ATP breakdown|activation of ATP catabolic process|activation of ATP catabolism|activation of ATP degradation|activation of ATP hydrolysis|positive regulation of ATP breakdown|positive regulation of ATP catabolism|positive regulation of ATP degradation|positive regulation of ATP hydrolysis|up regulation of ATP breakdown|up regulation of ATP catabolic process|up regulation of ATP catabolism|up regulation of ATP degradation|up regulation of ATP hydrolysis|up-regulation of ATP breakdown|up-regulation of ATP catabolic process|up-regulation of ATP catabolism|up-regulation of ATP degradation|up-regulation of ATP hydrolysis|upregulation of ATP breakdown|upregulation of ATP catabolic process|upregulation of ATP catabolism|upregulation of ATP degradation|upregulation of ATP hydrolysis True http://purl.obolibrary.org/obo/GO_1903291 GO:1903290 biolink:BiologicalProcess obsolete negative regulation of ATP catabolic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP catabolic process. go.json down regulation of ATP breakdown|down regulation of ATP catabolic process|down regulation of ATP catabolism|down regulation of ATP degradation|down regulation of ATP hydrolysis|down-regulation of ATP breakdown|down-regulation of ATP catabolic process|down-regulation of ATP catabolism|down-regulation of ATP degradation|down-regulation of ATP hydrolysis|downregulation of ATP breakdown|downregulation of ATP catabolic process|downregulation of ATP catabolism|downregulation of ATP degradation|downregulation of ATP hydrolysis|inhibition of ATP breakdown|inhibition of ATP catabolic process|inhibition of ATP catabolism|inhibition of ATP degradation|inhibition of ATP hydrolysis|negative regulation of ATP breakdown|negative regulation of ATP catabolism|negative regulation of ATP degradation|negative regulation of ATP hydrolysis True http://purl.obolibrary.org/obo/GO_1903290 GO:0097017 biolink:BiologicalProcess renal protein absorption A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). go.json http://purl.obolibrary.org/obo/GO_0097017 GO:0097016 biolink:MolecularActivity L27 domain binding Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner. go.json http://purl.obolibrary.org/obo/GO_0097016 GO:0097019 biolink:BiologicalProcess obsolete neurotransmitter receptor catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors. go.json neurotransmitter receptor breakdown|neurotransmitter receptor catabolism|neurotransmitter receptor degradation True http://purl.obolibrary.org/obo/GO_0097019 GO:0097018 biolink:BiologicalProcess renal albumin absorption A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. go.json http://purl.obolibrary.org/obo/GO_0097018 GO:0097024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097024 GO:0097023 biolink:MolecularActivity fructose 6-phosphate aldolase activity Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate. RHEA:28002 go.json http://purl.obolibrary.org/obo/GO_0097023 GO:0097026 biolink:BiologicalProcess dendritic cell dendrite assembly Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. go.json dendritic extension http://purl.obolibrary.org/obo/GO_0097026 GO:0097025 biolink:CellularComponent MPP7-DLG1-LIN7 complex A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions. go.json http://purl.obolibrary.org/obo/GO_0097025 GO:0097020 biolink:MolecularActivity COPII receptor activity Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. go.json http://purl.obolibrary.org/obo/GO_0097020 GO:0097022 biolink:BiologicalProcess lymphocyte migration into lymph node The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. go.json lymphocyte homing http://purl.obolibrary.org/obo/GO_0097022 GO:0097021 biolink:BiologicalProcess lymphocyte migration into lymphoid organs The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. go.json lymphocyte homing http://purl.obolibrary.org/obo/GO_0097021 GO:1903299 biolink:BiologicalProcess regulation of hexokinase activity Any process that modulates the frequency, rate or extent of hexokinase activity. go.json regulation of ATP-dependent hexokinase activity|regulation of ATP:D-hexose 6-phosphotransferase activity|regulation of glucose ATP phosphotransferase activity|regulation of hexokinase (phosphorylating)|regulation of hexokinase D|regulation of hexokinase type I activity|regulation of hexokinase type II activity|regulation of hexokinase type III activity|regulation of hexokinase type IV|regulation of hexokinase type IV (glucokinase) activity|regulation of hexokinase type IV glucokinase activity http://purl.obolibrary.org/obo/GO_1903299 gocheck_do_not_annotate GO:0097028 biolink:BiologicalProcess dendritic cell differentiation The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. go.json http://purl.obolibrary.org/obo/GO_0097028 GO:0097027 biolink:MolecularActivity ubiquitin-protein transferase activator activity Binds to and increases the activity of a ubiquitin-protein transferase. go.json http://purl.obolibrary.org/obo/GO_0097027 GO:0097029 biolink:BiologicalProcess mature conventional dendritic cell differentiation The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. go.json http://purl.obolibrary.org/obo/GO_0097029 GO:0000046 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000046 GO:0000045 biolink:BiologicalProcess autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. go.json PAS formation|autophagic vacuole assembly|autophagic vacuole formation|autophagosome biosynthesis|autophagosome formation http://purl.obolibrary.org/obo/GO_0000045 GO:0000044 biolink:BiologicalProcess obsolete ascorbate stabilization OBSOLETE. The reduction of the ascorbate free radical to a stable form. go.json ascorbate stabilization|vitamin C stabilization True http://purl.obolibrary.org/obo/GO_0000044 GO:0000043 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000043 GO:0000049 biolink:MolecularActivity tRNA binding Binding to a transfer RNA. go.json base pairing with tRNA http://purl.obolibrary.org/obo/GO_0000049 GO:0000048 biolink:MolecularActivity peptidyltransferase activity Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme. EC:2.3.2.12|MetaCyc:PEPTIDYLTRANSFERASE-RXN|Reactome:R-HSA-156912 go.json http://purl.obolibrary.org/obo/GO_0000048 GO:0000047 biolink:MolecularActivity obsolete Rieske iron-sulfur protein OBSOLETE. (Was not defined before being made obsolete). go.json Rieske iron-sulfur protein|Rieske iron-sulphur protein True http://purl.obolibrary.org/obo/GO_0000047 GO:0000042 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000042 GO:0000041 biolink:BiologicalProcess transition metal ion transport The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. go.json transition metal transport http://purl.obolibrary.org/obo/GO_0000041 GO:0000040 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000040 GO:0000057 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000057 GO:0000056 biolink:BiologicalProcess ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. go.json 30S ribosomal subunit export from nucleus|40S ribosomal subunit export from nucleus|ribosomal small subunit export from cell nucleus|ribosomal small subunit export out of nucleus|ribosomal small subunit transport from nucleus to cytoplasm|ribosomal small subunit-nucleus export http://purl.obolibrary.org/obo/GO_0000056 GO:0000055 biolink:BiologicalProcess ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. go.json 50S ribosomal subunit export from nucleus|60S ribosomal subunit export from nucleus|ribosomal large subunit export from cell nucleus|ribosomal large subunit export out of nucleus|ribosomal large subunit transport from nucleus to cytoplasm|ribosomal large subunit-nucleus export http://purl.obolibrary.org/obo/GO_0000055 GO:0000054 biolink:BiologicalProcess ribosomal subunit export from nucleus The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. go.json ribosomal subunit export from cell nucleus|ribosomal subunit export out of nucleus|ribosomal subunit transport from nucleus to cytoplasm|ribosomal subunit-nucleus export|ribosome export from nucleus http://purl.obolibrary.org/obo/GO_0000054 goslim_yeast GO:0000059 biolink:BiologicalProcess obsolete protein import into nucleus, docking OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex. go.json protein docking during protein import into nucleus|protein docking during protein transport from cytoplasm to nucleus|protein docking during protein-nucleus import|protein transport from cytoplasm to nucleus, docking|protein-nucleus import, docking True http://purl.obolibrary.org/obo/GO_0000059 GO:0000058 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000058 GO:0000053 biolink:BiologicalProcess argininosuccinate metabolic process The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. go.json argininosuccinate metabolism http://purl.obolibrary.org/obo/GO_0000053 GO:0000052 biolink:BiologicalProcess citrulline metabolic process The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. go.json citrulline metabolism http://purl.obolibrary.org/obo/GO_0000052 GO:0000051 biolink:BiologicalProcess obsolete urea cycle intermediate metabolic process OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. go.json urea cycle intermediate metabolic process|urea cycle intermediate metabolism True http://purl.obolibrary.org/obo/GO_0000051 GO:0000050 biolink:BiologicalProcess urea cycle The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. Wikipedia:Urea_cycle go.json ornithine cycle|urea biosynthesis|urea biosynthetic process http://purl.obolibrary.org/obo/GO_0000050 GO:0000024 biolink:BiologicalProcess maltose biosynthetic process The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). go.json malt sugar biosynthesis|malt sugar biosynthetic process|maltose anabolism|maltose biosynthesis|maltose formation|maltose synthesis http://purl.obolibrary.org/obo/GO_0000024 GO:0048002 biolink:BiologicalProcess antigen processing and presentation of peptide antigen The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. go.json antigen presentation, peptide antigen|peptide antigen processing and presentation http://purl.obolibrary.org/obo/GO_0048002 GO:0048001 biolink:MolecularActivity erythrose-4-phosphate dehydrogenase activity Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH. EC:1.2.1.72|KEGG_REACTION:R01825|MetaCyc:ERYTH4PDEHYDROG-RXN|RHEA:12056 go.json D-erythrose 4-phosphate:NAD+ oxidoreductase activity|E4P dehydrogenase activity|E4PDH|Epd dehydrogenase activity|GapB|erythrose 4-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0048001 GO:0000023 biolink:BiologicalProcess maltose metabolic process The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. go.json malt sugar metabolic process|malt sugar metabolism|maltose metabolism http://purl.obolibrary.org/obo/GO_0000023 GO:0000022 biolink:BiologicalProcess mitotic spindle elongation The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B. go.json microtubule sliding involved in mitotic spindle elongation|spindle elongation during mitosis http://purl.obolibrary.org/obo/GO_0000022 GO:0048000 biolink:MolecularActivity isoflavone 3'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O. EC:1.14.14.88|MetaCyc:RXN-3762|RHEA:22960 go.json formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)|isoflavone 3'-monooxygenase activity http://purl.obolibrary.org/obo/GO_0048000 GO:0000021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000021 GO:0000028 biolink:BiologicalProcess ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. go.json 30S ribosomal subunit assembly|40S ribosomal subunit assembly http://purl.obolibrary.org/obo/GO_0000028 GO:0000027 biolink:BiologicalProcess ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. go.json 50S ribosomal subunit assembly|60S ribosomal subunit assembly http://purl.obolibrary.org/obo/GO_0000027 GO:0000026 biolink:MolecularActivity alpha-1,2-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. Reactome:R-HSA-446187|Reactome:R-HSA-446215|Reactome:R-HSA-446216|Reactome:R-HSA-4551297|Reactome:R-HSA-4720478|Reactome:R-HSA-9035514 go.json http://purl.obolibrary.org/obo/GO_0000026 GO:0000025 biolink:BiologicalProcess maltose catabolic process The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). MetaCyc:MALTOSECAT-PWY go.json malt sugar catabolic process|malt sugar catabolism|maltose breakdown|maltose degradation|maltose hydrolysis http://purl.obolibrary.org/obo/GO_0000025 GO:0048009 biolink:BiologicalProcess insulin-like growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IGF receptor signaling pathway|IGF receptor signalling pathway http://purl.obolibrary.org/obo/GO_0048009 GO:0048008 biolink:BiologicalProcess platelet-derived growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json PDGF receptor signaling pathway|PDGF receptor signalling pathway|PDGFR signaling pathway http://purl.obolibrary.org/obo/GO_0048008 GO:0048007 biolink:BiologicalProcess antigen processing and presentation, exogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. go.json antigen presentation, exogenous peptide antigen|exogenous lipid antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0048007 GO:0000020 biolink:BiologicalProcess obsolete negative regulation of recombination within rDNA repeats OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. go.json negative regulation of recombination within rDNA repeats True http://purl.obolibrary.org/obo/GO_0000020 GO:0048006 biolink:BiologicalProcess antigen processing and presentation, endogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. go.json antigen presentation, endogenous lipid antigen|endogenous lipid antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0048006 GO:0048005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048005 GO:0048004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048004 GO:0048003 biolink:BiologicalProcess antigen processing and presentation of lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. go.json antigen presentation, lipid antigen|lipid antigen processing and presentation via MHC class Ib http://purl.obolibrary.org/obo/GO_0048003 GO:0000029 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000029 GO:0048013 biolink:BiologicalProcess ephrin receptor signaling pathway The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json Eph receptor signaling pathway|Eph receptor signalling pathway http://purl.obolibrary.org/obo/GO_0048013 GO:0000035 biolink:MolecularActivity acyl binding Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. go.json acyl-CoA or acyl binding http://purl.obolibrary.org/obo/GO_0000035 GO:0048012 biolink:BiologicalProcess hepatocyte growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json HGF receptor signaling pathway|HGF receptor signalling pathway|Met signaling pathway http://purl.obolibrary.org/obo/GO_0048012 GO:0000034 biolink:MolecularActivity adenine deaminase activity Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. EC:3.5.4.2|MetaCyc:ADENINE-DEAMINASE-RXN|RHEA:23688 go.json ADase activity|adenase activity|adenine aminase activity|adenine aminohydrolase activity http://purl.obolibrary.org/obo/GO_0000034 GO:0000033 biolink:MolecularActivity alpha-1,3-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. Reactome:R-HSA-446188|Reactome:R-HSA-446208|Reactome:R-HSA-4549368|Reactome:R-HSA-4720473 go.json http://purl.obolibrary.org/obo/GO_0000033 GO:0048011 biolink:BiologicalProcess neurotrophin TRK receptor signaling pathway The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TrkA signaling pathway|TrkB signaling pathway|TrkC signaling pathway|tropomyosin-receptor-kinase signaling http://purl.obolibrary.org/obo/GO_0048011 GO:0048010 biolink:BiologicalProcess vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json VEGF receptor signaling pathway|VEGF receptor signalling pathway|VEGFR signaling pathway http://purl.obolibrary.org/obo/GO_0048010 GO:0000032 biolink:BiologicalProcess cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. go.json cell wall mannoprotein anabolism|cell wall mannoprotein biosynthesis|cell wall mannoprotein formation|cell wall mannoprotein synthesis http://purl.obolibrary.org/obo/GO_0000032 GO:0000039 biolink:MolecularActivity obsolete plasma membrane long-chain fatty acid transporter OBSOLETE. (Was not defined before being made obsolete). go.json plasma membrane long-chain fatty acid transporter True http://purl.obolibrary.org/obo/GO_0000039 GO:0000038 biolink:BiologicalProcess very long-chain fatty acid metabolic process The chemical reactions and pathways involving a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons. go.json very long chain fatty acid metabolic process|very-long-chain fatty acid metabolic process|very-long-chain fatty acid metabolism http://purl.obolibrary.org/obo/GO_0000038 GO:0000037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000037 GO:0000036 biolink:MolecularActivity acyl carrier activity Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis. go.json ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0000036 GO:0048019 biolink:MolecularActivity receptor antagonist activity The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. go.json receptor ligand activity http://purl.obolibrary.org/obo/GO_0048019 GO:0048018 biolink:MolecularActivity receptor ligand activity The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). go.json receptor agonist activity|signaling molecule|signaling receptor ligand activity|vitamin D receptor activator activity http://purl.obolibrary.org/obo/GO_0048018 goslim_chembl|goslim_drosophila|goslim_generic GO:0048017 biolink:BiologicalProcess obsolete inositol lipid-mediated signaling OBSOLETE. The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. go.json inositol lipid-mediated signal transduction|inositol lipid-mediated signalling|inositol phospholipid-mediated signaling True http://purl.obolibrary.org/obo/GO_0048017 GO:0000031 biolink:MolecularActivity mannosylphosphate transferase activity Catalysis of the transfer of a mannosylphosphate group from one compound to another. go.json http://purl.obolibrary.org/obo/GO_0000031 GO:0000030 biolink:MolecularActivity mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. Reactome:R-HSA-162797|Reactome:R-HSA-162830|Reactome:R-HSA-446198|Reactome:R-HSA-4720497 go.json http://purl.obolibrary.org/obo/GO_0000030 GO:0048016 biolink:BiologicalProcess obsolete inositol phosphate-mediated signaling OBSOLETE. A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). go.json inositol phosphate-mediated signalling True http://purl.obolibrary.org/obo/GO_0048016 GO:0048015 biolink:BiologicalProcess phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. go.json inositol phospholipid-mediated signaling|phosphatidylinositol-mediated signal transduction|phosphatidylinositol-mediated signalling|phosphoinositide-mediated signaling|phosphoinositide-mediated signalling http://purl.obolibrary.org/obo/GO_0048015 GO:0048014 biolink:BiologicalProcess Tie signaling pathway The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json Tek receptor signaling|Tie receptor signaling pathway|Tie receptor signalling pathway|angiopoietin-Tie signaling pathway|angiopoietin/Tie signaling pathway http://purl.obolibrary.org/obo/GO_0048014 GO:0048024 biolink:BiologicalProcess regulation of mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. go.json regulation of nuclear mRNA splicing via U2-type spliceosome|regulation of nuclear mRNA splicing, via spliceosome|regulation of pre-mRNA splicing http://purl.obolibrary.org/obo/GO_0048024 GO:0000002 biolink:BiologicalProcess mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. go.json http://purl.obolibrary.org/obo/GO_0000002 GO:0000001 biolink:BiologicalProcess mitochondrion inheritance The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. go.json mitochondrial inheritance http://purl.obolibrary.org/obo/GO_0000001 GO:0048023 biolink:BiologicalProcess positive regulation of melanin biosynthetic process Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin. go.json activation of melanin biosynthetic process|positive regulation of melanin anabolism|positive regulation of melanin biosynthesis|positive regulation of melanin formation|positive regulation of melanin synthesis|stimulation of melanin biosynthetic process|up regulation of melanin biosynthetic process|up-regulation of melanin biosynthetic process|upregulation of melanin biosynthetic process http://purl.obolibrary.org/obo/GO_0048023 GO:0048022 biolink:BiologicalProcess negative regulation of melanin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. go.json down regulation of melanin biosynthetic process|down-regulation of melanin biosynthetic process|downregulation of melanin biosynthetic process|inhibition of melanin biosynthetic process|negative regulation of melanin anabolism|negative regulation of melanin biosynthesis|negative regulation of melanin formation|negative regulation of melanin synthesis http://purl.obolibrary.org/obo/GO_0048022 GO:0048021 biolink:BiologicalProcess regulation of melanin biosynthetic process Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. go.json regulation of melanin anabolism|regulation of melanin biosynthesis|regulation of melanin formation|regulation of melanin synthesis http://purl.obolibrary.org/obo/GO_0048021 GO:0000006 biolink:MolecularActivity high-affinity zinc transmembrane transporter activity Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity zinc uptake transmembrane transporter activity|high-affinity zinc uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0000006 GO:0048020 biolink:MolecularActivity CCR chemokine receptor binding Binding to a CCR chemokine receptor. go.json CCR chemokine receptor ligand|beta chemokine receptor binding|beta chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0048020 GO:0000005 biolink:MolecularActivity obsolete ribosomal chaperone activity OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function. go.json ribosomal chaperone activity True http://purl.obolibrary.org/obo/GO_0000005 GO:0000004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000004 GO:0000003 biolink:BiologicalProcess reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. Wikipedia:Reproduction go.json reproductive physiological process http://purl.obolibrary.org/obo/GO_0000003 goslim_agr|goslim_chembl|goslim_flybase_ribbon|goslim_pir|goslim_plant GO:0048029 biolink:MolecularActivity monosaccharide binding Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. go.json http://purl.obolibrary.org/obo/GO_0048029 GO:0048028 biolink:MolecularActivity galacturonan binding Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins. go.json polygalacturonide binding http://purl.obolibrary.org/obo/GO_0048028 GO:0048027 biolink:MolecularActivity mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region. go.json mRNA 5' UTR binding http://purl.obolibrary.org/obo/GO_0048027 GO:0048026 biolink:BiologicalProcess positive regulation of mRNA splicing, via spliceosome Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. go.json activation of nuclear mRNA splicing via U2-type spliceosome|activation of nuclear mRNA splicing, via spliceosome|positive regulation of nuclear mRNA splicing via U2-type spliceosome|positive regulation of nuclear mRNA splicing, via spliceosome|positive regulation of pre-mRNA splicing|stimulation of nuclear mRNA splicing via U2-type spliceosome|stimulation of nuclear mRNA splicing, via spliceosome|up regulation of nuclear mRNA splicing via U2-type spliceosome|up regulation of nuclear mRNA splicing, via spliceosome|up-regulation of nuclear mRNA splicing via U2-type spliceosome|up-regulation of nuclear mRNA splicing, via spliceosome|upregulation of nuclear mRNA splicing via U2-type spliceosome|upregulation of nuclear mRNA splicing, via spliceosome http://purl.obolibrary.org/obo/GO_0048026 GO:0048025 biolink:BiologicalProcess negative regulation of mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. go.json down regulation of nuclear mRNA splicing via U2-type spliceosome|down regulation of nuclear mRNA splicing, via spliceosome|down-regulation of nuclear mRNA splicing via U2-type spliceosome|down-regulation of nuclear mRNA splicing, via spliceosome|downregulation of nuclear mRNA splicing via U2-type spliceosome|downregulation of nuclear mRNA splicing, via spliceosome|inhibition of nuclear mRNA splicing via U2-type spliceosome|inhibition of nuclear mRNA splicing, via spliceosome|negative regulation of nuclear mRNA splicing via U2-type spliceosome|negative regulation of nuclear mRNA splicing, via spliceosome|negative regulation of pre-mRNA splicing http://purl.obolibrary.org/obo/GO_0048025 GO:0000009 biolink:MolecularActivity alpha-1,6-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. Reactome:R-HSA-449718 go.json 1,6-alpha-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0000009 GO:0000008 biolink:MolecularActivity obsolete thioredoxin OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol. go.json thioredoxin True http://purl.obolibrary.org/obo/GO_0000008 GO:0000007 biolink:MolecularActivity low-affinity zinc ion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json http://purl.obolibrary.org/obo/GO_0000007 GO:0000013 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000013 GO:0048035 biolink:BiologicalProcess heme O catabolic process The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. go.json haem O catabolic process|haem O catabolism|heme O breakdown|heme O catabolism|heme O degradation http://purl.obolibrary.org/obo/GO_0048035 GO:0048034 biolink:BiologicalProcess heme O biosynthetic process The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. go.json haem O biosynthesis|haem O biosynthetic process|heme O anabolism|heme O biosynthesis|heme O formation|heme O synthesis http://purl.obolibrary.org/obo/GO_0048034 GO:0000012 biolink:BiologicalProcess single strand break repair The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. go.json http://purl.obolibrary.org/obo/GO_0000012 GO:0000011 biolink:BiologicalProcess vacuole inheritance The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0000011 GO:0048033 biolink:BiologicalProcess heme O metabolic process The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. go.json haem O metabolic process|haem O metabolism|heme O metabolism http://purl.obolibrary.org/obo/GO_0048033 GO:0000010 biolink:MolecularActivity trans-hexaprenyltranstransferase activity Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate. EC:2.5.1.30|MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN|RHEA:27794 go.json HepPP synthase activity|all-trans-heptaprenyl-diphosphate synthase activity|heptaprenyl diphosphate synthase activity|heptaprenyl pyrophosphate synthase activity|heptaprenyl pyrophosphate synthetase activity http://purl.obolibrary.org/obo/GO_0000010 GO:0048032 biolink:MolecularActivity galacturonate binding Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. go.json galacturonic acid binding http://purl.obolibrary.org/obo/GO_0048032 GO:0000017 biolink:BiologicalProcess alpha-glucoside transport The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. go.json http://purl.obolibrary.org/obo/GO_0000017 GO:0048031 biolink:MolecularActivity trisaccharide binding Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units. go.json http://purl.obolibrary.org/obo/GO_0048031 GO:0048030 biolink:MolecularActivity disaccharide binding Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units. go.json http://purl.obolibrary.org/obo/GO_0048030 GO:0000016 biolink:MolecularActivity lactase activity Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. EC:3.2.1.108|MetaCyc:BETAGALACTOSID-RXN|RHEA:10076|Reactome:R-HSA-189062|Reactome:R-HSA-5658001 go.json lactose galactohydrolase activity http://purl.obolibrary.org/obo/GO_0000016 GO:0000015 biolink:CellularComponent phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. go.json enolase complex http://purl.obolibrary.org/obo/GO_0000015 goslim_metagenomics GO:0000014 biolink:MolecularActivity single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. go.json single-stranded DNA specific endodeoxyribonuclease activity|ssDNA-specific endodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0000014 GO:0048039 biolink:MolecularActivity ubiquinone binding Binding to ubiquinone, a quinone derivative with a tail of isoprene units. go.json coenzyme Q binding|coenzyme Q6 binding http://purl.obolibrary.org/obo/GO_0048039 GO:0048038 biolink:MolecularActivity quinone binding Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. go.json http://purl.obolibrary.org/obo/GO_0048038 GO:0048037 biolink:MolecularActivity obsolete cofactor binding OBSOLETE. Binding to a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. go.json True http://purl.obolibrary.org/obo/GO_0048037 GO:0048036 biolink:BiologicalProcess central complex development The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli. go.json central body development http://purl.obolibrary.org/obo/GO_0048036 GO:0000019 biolink:BiologicalProcess regulation of mitotic recombination Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. go.json regulation of recombination within rDNA repeats http://purl.obolibrary.org/obo/GO_0000019 GO:0000018 biolink:BiologicalProcess regulation of DNA recombination Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. go.json http://purl.obolibrary.org/obo/GO_0000018 GO:0048046 biolink:CellularComponent apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. Wikipedia:Apoplast go.json http://purl.obolibrary.org/obo/GO_0048046 GO:0048045 biolink:MolecularActivity obsolete trans-pentaprenyltranstransferase activity OBSOLETE. Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate. KEGG_REACTION:R05613 go.json all-trans-hexaprenyl-diphosphate synthase activity|all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity|hexaprenyl diphosphate synthase activity|hexaprenyl pyrophosphate synthetase activity True http://purl.obolibrary.org/obo/GO_0048045 GO:0048044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048044 GO:0048043 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048043 GO:0048042 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048042 GO:0048041 biolink:BiologicalProcess focal adhesion assembly The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. go.json adhesion plaque assembly|focal adhesion formation http://purl.obolibrary.org/obo/GO_0048041 GO:1903209 biolink:BiologicalProcess obsolete positive regulation of oxidative stress-induced cell death OBSOLETE. Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. go.json activation of cell death in response to oxidative stress|enhancement of oxidative stress-induced cell death|positive regulation of cell death in response to oxidative stress|up regulation of cell death in response to oxidative stress|up-regulation of cell death in response to oxidative stress|upregulation of cell death in response to oxidative stress True http://purl.obolibrary.org/obo/GO_1903209 GO:0048040 biolink:MolecularActivity UDP-glucuronate decarboxylase activity Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose. EC:4.1.1.35|KEGG_REACTION:R01384|MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN|RHEA:23916 go.json UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)|UDP-D-glucuronate carboxy-lyase activity|UDP-glucuronic acid decarboxylase activity|UDPglucuronate decarboxylase activity|uridine-diphosphoglucuronate decarboxylase activity http://purl.obolibrary.org/obo/GO_0048040 GO:1903208 biolink:BiologicalProcess obsolete negative regulation of hydrogen peroxide-induced neuron death OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced neuron death. go.json down regulation of hydrogen peroxide-induced neuron death|down regulation of neuron death in response to H2O2|down regulation of neuron death in response to hydrogen peroxide|down regulation of neuronal cell death in response to hydrogen peroxide|down-regulation of hydrogen peroxide-induced neuron death|down-regulation of neuron death in response to H2O2|down-regulation of neuron death in response to hydrogen peroxide|down-regulation of neuronal cell death in response to hydrogen peroxide|downregulation of hydrogen peroxide-induced neuron death|downregulation of neuron death in response to H2O2|downregulation of neuron death in response to hydrogen peroxide|downregulation of neuronal cell death in response to hydrogen peroxide|inhibition of hydrogen peroxide-induced neuron death|inhibition of neuron death in response to H2O2|inhibition of neuron death in response to hydrogen peroxide|inhibition of neuronal cell death in response to hydrogen peroxide|negative regulation of neuron death in response to H2O2|negative regulation of neuron death in response to hydrogen peroxide|negative regulation of neuronal cell death in response to hydrogen peroxide|neuroprotection against H2O2-induced cell death|neuroprotection against hydrogen peroxide|protection against H2O2-induced neuron death|protection against hydrogen peroxide-induced neuron death True http://purl.obolibrary.org/obo/GO_1903208 GO:1903207 biolink:BiologicalProcess obsolete regulation of hydrogen peroxide-induced neuron death OBSOLETE. Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced neuron death. go.json regulation of neuron death in response to H2O2|regulation of neuron death in response to hydrogen peroxide|regulation of neuronal cell death in response to hydrogen peroxide True http://purl.obolibrary.org/obo/GO_1903207 GO:1903206 biolink:BiologicalProcess obsolete negative regulation of hydrogen peroxide-induced cell death OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death. go.json down regulation of cell death in response to H2O2|down regulation of cell death in response to hydrogen peroxide|down regulation of hydrogen peroxide-mediated cell death|down-regulation of cell death in response to H2O2|down-regulation of cell death in response to hydrogen peroxide|down-regulation of hydrogen peroxide-mediated cell death|downregulation of cell death in response to H2O2|downregulation of cell death in response to hydrogen peroxide|downregulation of hydrogen peroxide-mediated cell death|inhibition of cell death in response to H2O2|inhibition of cell death in response to hydrogen peroxide|inhibition of hydrogen peroxide-mediated cell death|negative regulation of cell death in response to H2O2|negative regulation of cell death in response to hydrogen peroxide|negative regulation of hydrogen peroxide-mediated cell death|protection against H2O2-induced cell death|protection against hydrogen peroxide-induced cell death True http://purl.obolibrary.org/obo/GO_1903206 GO:1903205 biolink:BiologicalProcess obsolete regulation of hydrogen peroxide-induced cell death OBSOLETE. Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. go.json protection against hydrogen peroxide-mediated cell death|regulation of cell death in response to H2O2|regulation of cell death in response to hydrogen peroxide|regulation of hydrogen peroxide-mediated cell death True http://purl.obolibrary.org/obo/GO_1903205 GO:1903204 biolink:BiologicalProcess obsolete negative regulation of oxidative stress-induced neuron death OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death. go.json down regulation of neuron death in response to oxidative stress|down regulation of neuronal cell death in response to oxidative stress|down regulation of oxidative stress-induced neuron death|down-regulation of neuron death in response to oxidative stress|down-regulation of neuronal cell death in response to oxidative stress|down-regulation of oxidative stress-induced neuron death|downregulation of neuron death in response to oxidative stress|downregulation of neuronal cell death in response to oxidative stress|downregulation of oxidative stress-induced neuron death|inhibition of neuron death in response to oxidative stress|inhibition of neuronal cell death in response to oxidative stress|inhibition of oxidative stress-induced neuron death|negative regulation of neuronal cell death in response to oxidative stress|neuronal protection under oxidative stress|neuroprotection against oxidative stress True http://purl.obolibrary.org/obo/GO_1903204 GO:1903203 biolink:BiologicalProcess obsolete regulation of oxidative stress-induced neuron death OBSOLETE. Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. go.json regulation of neuron death in response to oxidative stress|regulation of neuronal cell death in response to oxidative stress True http://purl.obolibrary.org/obo/GO_1903203 GO:1903202 biolink:BiologicalProcess obsolete negative regulation of oxidative stress-induced cell death OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death. go.json down regulation of cell death in response to oxidative stress|down-regulation of cell death in response to oxidative stress|downregulation of cell death in response to oxidative stress|inhibition of cell death in response to oxidative stress|negative regulation of cell death in response to oxidative stress|protection against oxidative stress-induced cell death True http://purl.obolibrary.org/obo/GO_1903202 GO:0048049 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048049 GO:1903201 biolink:BiologicalProcess obsolete regulation of oxidative stress-induced cell death OBSOLETE. Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. go.json regulation of cell death in response to oxidative stress True http://purl.obolibrary.org/obo/GO_1903201 GO:0048048 biolink:BiologicalProcess embryonic eye morphogenesis The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048048 GO:1903200 biolink:BiologicalProcess positive regulation of L-dopa decarboxylase activity Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity. go.json activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|activation of DDC activity|activation of DOPA decarboxylase activity|activation of L-dopa decarboxylase activity|positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|positive regulation of DDC activity|positive regulation of DOPA decarboxylase activity|up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|up regulation of DDC activity|up regulation of DOPA decarboxylase activity|up regulation of L-dopa decarboxylase activity|up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|up-regulation of DDC activity|up-regulation of DOPA decarboxylase activity|up-regulation of L-dopa decarboxylase activity|upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|upregulation of DDC activity|upregulation of DOPA decarboxylase activity|upregulation of L-dopa decarboxylase activity http://purl.obolibrary.org/obo/GO_1903200 gocheck_do_not_annotate GO:0048047 biolink:BiologicalProcess mating behavior, sex discrimination The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner. go.json mating behaviour, sex discrimination http://purl.obolibrary.org/obo/GO_0048047 GO:1903210 biolink:BiologicalProcess podocyte apoptotic process Any apoptotic process in a glomerular visceral epithelial cell. go.json glomerular podocyte apoptosis|glomerular podocyte apoptotic process|glomerular visceral epithelial cell apoptosis|glomerular visceral epithelial cell apoptotic process|podocyte apoptosis http://purl.obolibrary.org/obo/GO_1903210 GO:0048057 biolink:BiologicalProcess R3/R4 development The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048057 GO:0048056 biolink:BiologicalProcess R3/R4 cell differentiation The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048056 GO:0048055 biolink:BiologicalProcess R2/R5 development The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048055 GO:0048054 biolink:BiologicalProcess R2/R5 cell differentiation The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048054 GO:0048053 biolink:BiologicalProcess R1/R6 development The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048053 GO:0048052 biolink:BiologicalProcess R1/R6 cell differentiation The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0048052 GO:0048051 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048051 GO:1903219 biolink:BiologicalProcess negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity. go.json down regulation of 'malic' enzyme|down regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|down regulation of L-malate:NADP oxidoreductase activity|down regulation of NADP-linked decarboxylating malic enzyme|down regulation of NADP-malic enzyme activity|down regulation of NADP-specific malate dehydrogenase activity|down regulation of NADP-specific malic enzyme|down regulation of malate dehydrogenase (NADP, decarboxylating)|down regulation of malate dehydrogenase (decarboxylating) (NADP+) activity|down regulation of malate dehydrogenase (decarboxylating, NADP)|down-regulation of 'malic' enzyme|down-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|down-regulation of L-malate:NADP oxidoreductase activity|down-regulation of NADP-linked decarboxylating malic enzyme|down-regulation of NADP-malic enzyme activity|down-regulation of NADP-specific malate dehydrogenase activity|down-regulation of NADP-specific malic enzyme|down-regulation of malate dehydrogenase (NADP, decarboxylating)|down-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity|down-regulation of malate dehydrogenase (decarboxylating, NADP)|downregulation of 'malic' enzyme|downregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|downregulation of L-malate:NADP oxidoreductase activity|downregulation of NADP-linked decarboxylating malic enzyme|downregulation of NADP-malic enzyme activity|downregulation of NADP-specific malate dehydrogenase activity|downregulation of NADP-specific malic enzyme|downregulation of malate dehydrogenase (NADP, decarboxylating)|downregulation of malate dehydrogenase (decarboxylating) (NADP+) activity|downregulation of malate dehydrogenase (decarboxylating, NADP)|inhibition of 'malic' enzyme|inhibition of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|inhibition of L-malate:NADP oxidoreductase activity|inhibition of NADP-linked decarboxylating malic enzyme|inhibition of NADP-malic enzyme activity|inhibition of NADP-specific malate dehydrogenase activity|inhibition of NADP-specific malic enzyme|inhibition of malate dehydrogenase (NADP, decarboxylating)|inhibition of malate dehydrogenase (decarboxylating) (NADP+) activity|inhibition of malate dehydrogenase (decarboxylating, NADP)|negative regulation of 'malic' enzyme|negative regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|negative regulation of L-malate:NADP oxidoreductase activity|negative regulation of NADP-linked decarboxylating malic enzyme|negative regulation of NADP-malic enzyme activity|negative regulation of NADP-specific malate dehydrogenase activity|negative regulation of NADP-specific malic enzyme|negative regulation of malate dehydrogenase (NADP, decarboxylating)|negative regulation of malate dehydrogenase (decarboxylating, NADP) http://purl.obolibrary.org/obo/GO_1903219 gocheck_do_not_annotate GO:0048050 biolink:BiologicalProcess post-embryonic eye morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight. go.json http://purl.obolibrary.org/obo/GO_0048050 GO:1903218 biolink:BiologicalProcess regulation of malate dehydrogenase (decarboxylating) (NADP+) activity Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity. go.json regulation of 'malic' enzyme|regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|regulation of L-malate:NADP oxidoreductase activity|regulation of NADP-linked decarboxylating malic enzyme|regulation of NADP-malic enzyme activity|regulation of NADP-specific malate dehydrogenase activity|regulation of NADP-specific malic enzyme|regulation of malate dehydrogenase (NADP, decarboxylating)|regulation of malate dehydrogenase (decarboxylating, NADP) http://purl.obolibrary.org/obo/GO_1903218 gocheck_do_not_annotate GO:1903217 biolink:BiologicalProcess negative regulation of protein processing involved in protein targeting to mitochondrion Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion. go.json down regulation of mitochondrial protein processing during import|down regulation of protein processing involved in protein targeting to mitochondrion|down-regulation of mitochondrial protein processing during import|down-regulation of protein processing involved in protein targeting to mitochondrion|downregulation of mitochondrial protein processing during import|downregulation of protein processing involved in protein targeting to mitochondrion|inhibition of mitochondrial protein processing during import|inhibition of protein processing involved in protein targeting to mitochondrion|negative regulation of mitochondrial protein processing during import http://purl.obolibrary.org/obo/GO_1903217 GO:1903216 biolink:BiologicalProcess regulation of protein processing involved in protein targeting to mitochondrion Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion. go.json regulation of mitochondrial processing|regulation of mitochondrial protein processing during import http://purl.obolibrary.org/obo/GO_1903216 GO:1903215 biolink:BiologicalProcess negative regulation of protein targeting to mitochondrion Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion. go.json down regulation of mitochondrial protein import|down regulation of mitochondrial translocation|down regulation of protein import into mitochondrion|down regulation of protein targeting to mitochondria|down regulation of protein targeting to mitochondrion|down regulation of protein-mitochondrial targeting|down-regulation of mitochondrial protein import|down-regulation of mitochondrial translocation|down-regulation of protein import into mitochondrion|down-regulation of protein targeting to mitochondria|down-regulation of protein targeting to mitochondrion|down-regulation of protein-mitochondrial targeting|downregulation of mitochondrial protein import|downregulation of mitochondrial translocation|downregulation of protein import into mitochondrion|downregulation of protein targeting to mitochondria|downregulation of protein targeting to mitochondrion|downregulation of protein-mitochondrial targeting|inhibition of mitochondrial protein import|inhibition of mitochondrial translocation|inhibition of protein import into mitochondrion|inhibition of protein targeting to mitochondria|inhibition of protein targeting to mitochondrion|inhibition of protein-mitochondrial targeting|negative regulation of mitochondrial protein import|negative regulation of mitochondrial translocation|negative regulation of protein import into mitochondrion|negative regulation of protein targeting to mitochondria|negative regulation of protein-mitochondrial targeting http://purl.obolibrary.org/obo/GO_1903215 GO:1903214 biolink:BiologicalProcess regulation of protein targeting to mitochondrion Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. go.json regulation of mitochondrial protein import|regulation of mitochondrial translocation|regulation of protein import into mitochondrion|regulation of protein targeting to mitochondria|regulation of protein-mitochondrial targeting http://purl.obolibrary.org/obo/GO_1903214 GO:1903213 biolink:BiologicalProcess protein localization to subtelomeric heterochromatin A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin. go.json protein localisation in subtelomeric heterochromatin|protein localisation to subtelomeric heterochromatin|protein localisation to telomeric heterochromatin|protein localization in subtelomeric heterochromatin|protein localization to telomeric heterochromatin http://purl.obolibrary.org/obo/GO_1903213 GO:1903212 biolink:BiologicalProcess protein localization to mating-type region heterochromatin A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin. go.json protein localisation in mating-type region heterochromatin|protein localisation to mating-type region heterochromatin|protein localization in mating-type region heterochromatin http://purl.obolibrary.org/obo/GO_1903212 GO:0048059 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048059 GO:0048058 biolink:BiologicalProcess compound eye corneal lens development The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells. go.json http://purl.obolibrary.org/obo/GO_0048058 GO:1903211 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903211 GO:1903221 biolink:BiologicalProcess regulation of mitotic recombination-dependent replication fork processing Any process that modulates the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. go.json prevention of genomic instability induced by DNA replication fork arrest|regulation of mitotic recombination involved in collapsed replication fork processing|regulation of mitotic recombination involved in recovery from replication fork arrest|regulation of mitotic recombination involved in recovery from replication fork stalling|regulation of mitotic recombination involved in replication fork processing|regulation of mitotic recombination involved in replication fork restart|regulation of mitotic recombination involved in replication restart http://purl.obolibrary.org/obo/GO_1903221 GO:1903220 biolink:BiologicalProcess positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity Any process that activates or increases the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity. go.json activation of 'malic' enzyme|activation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|activation of L-malate:NADP oxidoreductase activity|activation of NADP-linked decarboxylating malic enzyme|activation of NADP-malic enzyme activity|activation of NADP-specific malate dehydrogenase activity|activation of NADP-specific malic enzyme|activation of malate dehydrogenase (NADP, decarboxylating)|activation of malate dehydrogenase (decarboxylating) (NADP+) activity|activation of malate dehydrogenase (decarboxylating, NADP)|positive regulation of 'malic' enzyme|positive regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|positive regulation of L-malate:NADP oxidoreductase activity|positive regulation of NADP-linked decarboxylating malic enzyme|positive regulation of NADP-malic enzyme activity|positive regulation of NADP-specific malate dehydrogenase activity|positive regulation of NADP-specific malic enzyme|positive regulation of malate dehydrogenase (NADP, decarboxylating)|positive regulation of malate dehydrogenase (decarboxylating, NADP)|up regulation of 'malic' enzyme|up regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|up regulation of L-malate:NADP oxidoreductase activity|up regulation of NADP-linked decarboxylating malic enzyme|up regulation of NADP-malic enzyme activity|up regulation of NADP-specific malate dehydrogenase activity|up regulation of NADP-specific malic enzyme|up regulation of malate dehydrogenase (NADP, decarboxylating)|up regulation of malate dehydrogenase (decarboxylating) (NADP+) activity|up regulation of malate dehydrogenase (decarboxylating, NADP)|up-regulation of 'malic' enzyme|up-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|up-regulation of L-malate:NADP oxidoreductase activity|up-regulation of NADP-linked decarboxylating malic enzyme|up-regulation of NADP-malic enzyme activity|up-regulation of NADP-specific malate dehydrogenase activity|up-regulation of NADP-specific malic enzyme|up-regulation of malate dehydrogenase (NADP, decarboxylating)|up-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity|up-regulation of malate dehydrogenase (decarboxylating, NADP)|upregulation of 'malic' enzyme|upregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|upregulation of L-malate:NADP oxidoreductase activity|upregulation of NADP-linked decarboxylating malic enzyme|upregulation of NADP-malic enzyme activity|upregulation of NADP-specific malate dehydrogenase activity|upregulation of NADP-specific malic enzyme|upregulation of malate dehydrogenase (NADP, decarboxylating)|upregulation of malate dehydrogenase (decarboxylating) (NADP+) activity|upregulation of malate dehydrogenase (decarboxylating, NADP) http://purl.obolibrary.org/obo/GO_1903220 gocheck_do_not_annotate GO:0048060 biolink:BiologicalProcess negative gravitaxis The directed movement of a motile cell or organism away from the source of gravity. go.json negative geotactic behavior|negative geotactic behaviour|negative gravitactic behavior|negative gravitactic behaviour|negative taxis in response to gravity|negative taxis in response to gravitytaxis in response to gravitational stimulus http://purl.obolibrary.org/obo/GO_0048060 GO:0000089 biolink:BiologicalProcess mitotic metaphase The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0000089 gocheck_do_not_annotate GO:0000088 biolink:BiologicalProcess mitotic prophase The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. go.json http://purl.obolibrary.org/obo/GO_0000088 gocheck_do_not_annotate GO:0000087 biolink:BiologicalProcess mitotic M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. go.json M phase of mitotic cell cycle|M-phase of mitotic cell cycle http://purl.obolibrary.org/obo/GO_0000087 gocheck_do_not_annotate GO:0000082 biolink:BiologicalProcess G1/S transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. go.json http://purl.obolibrary.org/obo/GO_0000082 GO:0000081 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000081 GO:0000080 biolink:BiologicalProcess mitotic G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis. go.json G1 phase of mitotic cell cycle http://purl.obolibrary.org/obo/GO_0000080 gocheck_do_not_annotate GO:0000086 biolink:BiologicalProcess G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. go.json mitotic G2/M transition http://purl.obolibrary.org/obo/GO_0000086 GO:0000085 biolink:BiologicalProcess mitotic G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis. go.json G2 phase of mitotic cell cycle http://purl.obolibrary.org/obo/GO_0000085 gocheck_do_not_annotate GO:0000084 biolink:BiologicalProcess mitotic S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle. go.json S phase of mitotic cell cycle|S-phase of mitotic cell cycle http://purl.obolibrary.org/obo/GO_0000084 gocheck_do_not_annotate GO:0000083 biolink:BiologicalProcess obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle OBSOLETE. Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. go.json True http://purl.obolibrary.org/obo/GO_0000083 GO:0000099 biolink:MolecularActivity sulfur amino acid transmembrane transporter activity Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. go.json sulfur amino acid transporter activity|sulphur amino acid transmembrane transporter activity|sulphur amino acid transporter activity http://purl.obolibrary.org/obo/GO_0000099 GO:0000098 biolink:BiologicalProcess sulfur amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. go.json sulfur amino acid breakdown|sulfur amino acid catabolism|sulfur amino acid degradation|sulphur amino acid catabolic process|sulphur amino acid catabolism http://purl.obolibrary.org/obo/GO_0000098 GO:0000093 biolink:BiologicalProcess mitotic telophase The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. go.json http://purl.obolibrary.org/obo/GO_0000093 gocheck_do_not_annotate GO:0000092 biolink:BiologicalProcess mitotic anaphase B The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis. go.json http://purl.obolibrary.org/obo/GO_0000092 gocheck_do_not_annotate GO:0000091 biolink:BiologicalProcess mitotic anaphase A The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis. go.json http://purl.obolibrary.org/obo/GO_0000091 gocheck_do_not_annotate GO:0000090 biolink:BiologicalProcess mitotic anaphase The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0000090 gocheck_do_not_annotate GO:0000097 biolink:BiologicalProcess sulfur amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. go.json sulfur amino acid anabolism|sulfur amino acid biosynthesis|sulfur amino acid formation|sulfur amino acid synthesis|sulphur amino acid biosynthesis|sulphur amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_0000097 GO:0000096 biolink:BiologicalProcess sulfur amino acid metabolic process The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. go.json sulfur amino acid metabolism|sulphur amino acid metabolic process|sulphur amino acid metabolism http://purl.obolibrary.org/obo/GO_0000096 GO:0000095 biolink:MolecularActivity S-adenosyl-L-methionine transmembrane transporter activity Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. Reactome:R-HSA-8855062 go.json S-adenosyl methionine permease activity|S-adenosyl methionine transporter activity|S-adenosylmethionine permease activity|S-adenosylmethionine transmembrane transporter activity|S-adenosylmethionine transporter activity|SAM transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0000095 GO:0000094 biolink:BiologicalProcess obsolete septin assembly and septum formation OBSOLETE. (Was not defined before being made obsolete). go.json septin assembly and septum formation True http://purl.obolibrary.org/obo/GO_0000094 GO:0000068 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000068 GO:0000067 biolink:BiologicalProcess obsolete DNA replication and chromosome cycle OBSOLETE. (Was not defined before being made obsolete). go.json DNA replication and chromosome cycle True http://purl.obolibrary.org/obo/GO_0000067 GO:0000066 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000066 GO:0000065 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000065 GO:0000069 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000069 GO:0000060 biolink:BiologicalProcess obsolete protein import into nucleus, translocation OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. go.json protein import into cell nucleus, translocation|protein translocation during protein import into nucleus|protein translocation during protein transport from cytoplasm to nucleus|protein translocation during protein-nucleus import|protein transport from cytoplasm to nucleus, translocation|protein-nucleus import, translocation True http://purl.obolibrary.org/obo/GO_0000060 GO:0000064 biolink:MolecularActivity L-ornithine transmembrane transporter activity Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. Reactome:R-HSA-70634 go.json L-ornithine transporter activity|histidine/arginine/lysine/ornithine porter activity http://purl.obolibrary.org/obo/GO_0000064 GO:0000063 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000063 GO:0000062 biolink:MolecularActivity fatty-acyl-CoA binding Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. go.json fatty-acyl binding|fatty-acyl-coenzyme A binding http://purl.obolibrary.org/obo/GO_0000062 GO:0000061 biolink:BiologicalProcess obsolete protein import into nucleus, substrate release OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex. go.json protein import into cell nucleus, substrate release|protein substrate release during protein import into nucleus|protein substrate release during protein transport from cytoplasm to nucleus|protein substrate release during protein-nucleus import|protein transport from cytoplasm to nucleus, substrate release|protein-nucleus import, substrate release True http://purl.obolibrary.org/obo/GO_0000061 GO:0000079 biolink:BiologicalProcess regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. go.json regulation of CDK activity|regulation of cyclin-dependent protein kinase activity http://purl.obolibrary.org/obo/GO_0000079 gocheck_do_not_annotate GO:0000078 biolink:BiologicalProcess obsolete cytokinesis after mitosis checkpoint OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis. go.json cell morphogenesis checkpoint|cell shape checkpoint True http://purl.obolibrary.org/obo/GO_0000078 GO:0000077 biolink:BiologicalProcess DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint. Wikipedia:DNA_damage_checkpoint|Wikipedia:Postreplication_checkpoint go.json DNA damage checkpoint|DNA damage response, signal transduction resulting in cell cycle arrest|signal transduction involved in DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0000077 GO:0000076 biolink:BiologicalProcess DNA replication checkpoint signaling A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. go.json DNA replication checkpoint|signal transduction involved in DNA replication checkpoint http://purl.obolibrary.org/obo/GO_0000076 GO:0000071 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000071 GO:0000070 biolink:BiologicalProcess mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. go.json mitotic chromosome segregation|mitotic sister-chromatid adhesion release http://purl.obolibrary.org/obo/GO_0000070 goslim_pombe GO:0000075 biolink:BiologicalProcess cell cycle checkpoint signaling A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. Wikipedia:Cell_cycle_checkpoint go.json G1/S checkpoint|G1/S transition checkpoint|G2/M checkpoint|G2/M transition checkpoint|cell cycle checkpoint|signal transduction involved in G2/M transition checkpoint|signal transduction involved in cell cycle checkpoint http://purl.obolibrary.org/obo/GO_0000075 gocheck_do_not_annotate GO:0000074 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000074 GO:0000073 biolink:BiologicalProcess initial mitotic spindle pole body separation The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB. go.json http://purl.obolibrary.org/obo/GO_0000073 GO:0000072 biolink:BiologicalProcess obsolete M phase specific microtubule process OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle. go.json M phase specific microtubule process|M-phase specific microtubule process True http://purl.obolibrary.org/obo/GO_0000072 GO:0097199 biolink:MolecularActivity cysteine-type endopeptidase activity involved in apoptotic signaling pathway Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. go.json activator caspase activity|apical caspase activity|cysteine-type endopeptidase activity involved in apoptotic signalling pathway|initiator caspase activity http://purl.obolibrary.org/obo/GO_0097199 GO:0097196 biolink:CellularComponent Shu complex A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p. go.json http://purl.obolibrary.org/obo/GO_0097196 GO:0097195 biolink:BiologicalProcess pilomotor reflex The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect. go.json goosebump reflex|horripilation|piloerection http://purl.obolibrary.org/obo/GO_0097195 GO:0097198 biolink:BiologicalProcess histone H3-K36 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone. go.json http://purl.obolibrary.org/obo/GO_0097198 gocheck_do_not_annotate GO:0097197 biolink:CellularComponent tetraspanin-enriched microdomain A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. go.json TEM|membrane tetraspanin-enriched microdomain http://purl.obolibrary.org/obo/GO_0097197 GO:0097192 biolink:BiologicalProcess extrinsic apoptotic signaling pathway in absence of ligand The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. go.json dependence receptor signaling pathway|extrinsic apoptosis in absence of ligand|extrinsic apoptotic signalling pathway in absence of ligand http://purl.obolibrary.org/obo/GO_0097192 GO:0097191 biolink:BiologicalProcess extrinsic apoptotic signaling pathway The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. go.json death receptor-mediated apoptosis|extrinsic apoptosis|extrinsic apoptotic pathway|extrinsic apoptotic signaling pathway in presence of ligand|extrinsic apoptotic signalling pathway http://purl.obolibrary.org/obo/GO_0097191 GO:0097194 biolink:BiologicalProcess execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. go.json apoptosis|execution phase of apoptotic process http://purl.obolibrary.org/obo/GO_0097194 GO:0097193 biolink:BiologicalProcess intrinsic apoptotic signaling pathway The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). go.json induction of apoptosis by intracellular signals|intrinsic apoptosis|intrinsic apoptotic pathway|intrinsic apoptotic signalling pathway|mitochondrial-mediated apoptotic pathway http://purl.obolibrary.org/obo/GO_0097193 GO:0097190 biolink:BiologicalProcess apoptotic signaling pathway The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. go.json apoptotic signalling pathway|induction of apoptosis by extracellular signals http://purl.obolibrary.org/obo/GO_0097190 GO:0097178 biolink:BiologicalProcess ruffle assembly The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. go.json membrane ruffle formation|membrane ruffling http://purl.obolibrary.org/obo/GO_0097178 GO:0097177 biolink:MolecularActivity mitochondrial ribosome binding Binding to a mitochondrial ribosome. go.json http://purl.obolibrary.org/obo/GO_0097177 GO:0097179 biolink:CellularComponent protease inhibitor complex A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity. go.json peptidase inhibitor complex http://purl.obolibrary.org/obo/GO_0097179 GO:0097174 biolink:BiologicalProcess 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid. go.json 1,6-anhydro-N-acetyl-beta-muramate metabolic process|1,6-anhydro-N-acetyl-beta-muramate metabolism|1,6-anhydro-N-acetyl-beta-muramic acid metabolism|1,6-anhydro-N-acetylmuramic acid metabolic process|1,6-anhydro-N-acetylmuramic acid metabolism http://purl.obolibrary.org/obo/GO_0097174 GO:0097173 biolink:BiologicalProcess N-acetylmuramic acid catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine. go.json N-acetylmuramate breakdown|N-acetylmuramate catabolic process|N-acetylmuramate catabolism|N-acetylmuramate degradation|N-acetylmuramic acid breakdown|N-acetylmuramic acid catabolism|N-acetylmuramic acid degradation http://purl.obolibrary.org/obo/GO_0097173 GO:0097176 biolink:BiologicalProcess epoxide metabolic process The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers. go.json epoxide metabolism http://purl.obolibrary.org/obo/GO_0097176 GO:0097175 biolink:BiologicalProcess 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid. go.json 1,6-anhydro-N-acetyl-beta-muramate breakdown|1,6-anhydro-N-acetyl-beta-muramate catabolic process|1,6-anhydro-N-acetyl-beta-muramate catabolism|1,6-anhydro-N-acetyl-beta-muramate degradation|1,6-anhydro-N-acetyl-beta-muramic acid breakdown|1,6-anhydro-N-acetyl-beta-muramic acid catabolism|1,6-anhydro-N-acetyl-beta-muramic acid degradation|1,6-anhydro-N-acetylmuramate breakdown|1,6-anhydro-N-acetylmuramate catabolic process|1,6-anhydro-N-acetylmuramate catabolism|1,6-anhydro-N-acetylmuramate degradation|1,6-anhydro-N-acetylmuramic acid breakdown|1,6-anhydro-N-acetylmuramic acid catabolic process|1,6-anhydro-N-acetylmuramic acid catabolism|1,6-anhydro-N-acetylmuramic acid degradation http://purl.obolibrary.org/obo/GO_0097175 GO:0097170 biolink:BiologicalProcess ADP-L-glycero-beta-D-manno-heptose metabolic process The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate. go.json ADP-L-glycero-beta-D-manno-heptose metabolism http://purl.obolibrary.org/obo/GO_0097170 GO:0097172 biolink:BiologicalProcess N-acetylmuramic acid metabolic process The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine. go.json N-acetylmuramate metabolic process|N-acetylmuramate metabolism|N-acetylmuramic acid metabolism http://purl.obolibrary.org/obo/GO_0097172 GO:0097171 biolink:BiologicalProcess ADP-L-glycero-beta-D-manno-heptose biosynthetic process The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate. go.json ADP-L-glycero-beta-D-manno-heptose anabolism|ADP-L-glycero-beta-D-manno-heptose biosynthesis|ADP-L-glycero-beta-D-manno-heptose formation|ADP-L-glycero-beta-D-manno-heptose synthesis http://purl.obolibrary.org/obo/GO_0097171 GO:0097189 biolink:CellularComponent apoptotic body A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um. go.json apoptotic bleb|apoptotic vesicle http://purl.obolibrary.org/obo/GO_0097189 GO:0097188 biolink:BiologicalProcess dentin mineralization The process in which calcium salts are deposited into the calcareous tooth structure known as dentin. go.json dentine mineralization http://purl.obolibrary.org/obo/GO_0097188 GO:0097185 biolink:BiologicalProcess cellular response to azide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus. go.json http://purl.obolibrary.org/obo/GO_0097185 GO:0097184 biolink:BiologicalProcess response to azide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus. go.json http://purl.obolibrary.org/obo/GO_0097184 GO:0097187 biolink:BiologicalProcess dentinogenesis The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. go.json dentin development|dentine development http://purl.obolibrary.org/obo/GO_0097187 GO:0097186 biolink:BiologicalProcess amelogenesis The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. go.json enamel development http://purl.obolibrary.org/obo/GO_0097186 GO:0097181 biolink:CellularComponent protein C inhibitor-coagulation factor V complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V. go.json PCI-coagulation factor V complex|SERPINA5-coagulation factor V complex|plasma serine protease inhibitor-coagulation factor V complex|protein C inhibitor-F5 complex|serpin A5-coagulation factor V complex http://purl.obolibrary.org/obo/GO_0097181 GO:0097180 biolink:CellularComponent serine protease inhibitor complex A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. go.json serine-type endopeptidase inhibitor complex|serpin complex http://purl.obolibrary.org/obo/GO_0097180 GO:0097183 biolink:CellularComponent protein C inhibitor-coagulation factor XI complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI. go.json PCI-coagulation factor XI complex|SERPINA5-coagulation factor XI complex|plasma serine protease inhibitor-coagulation factor XI complex|protein C inhibitor-F11 complex|serpin A5-coagulation factor XI complex http://purl.obolibrary.org/obo/GO_0097183 GO:0097182 biolink:CellularComponent protein C inhibitor-coagulation factor Xa complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa. go.json PCI-coagulation factor Xa complex|SERPINA5-coagulation factor Xa complex|plasma serine protease inhibitor-coagulation factor Xa complex|serpin A5-coagulation factor Xa complex http://purl.obolibrary.org/obo/GO_0097182 GO:0000200 biolink:BiologicalProcess obsolete inactivation of MAPK activity involved in cell wall organization or biogenesis OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis. go.json cell wall biogenesis, inactivation of MAPK activity|cell wall biogenesis, termination of MAPK activity|inactivation of MAPK activity involved in cell wall integrity|inactivation of MAPK activity involved in cell wall organization or biogenesis|termination of MAPK activity during cell wall biogenesis True http://purl.obolibrary.org/obo/GO_0000200 GO:0097112 biolink:BiologicalProcess gamma-aminobutyric acid receptor clustering The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane. go.json GABA receptor clustering http://purl.obolibrary.org/obo/GO_0097112 GO:0048189 biolink:CellularComponent Lid2 complex A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1. go.json http://purl.obolibrary.org/obo/GO_0048189 GO:0048188 biolink:CellularComponent Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. go.json COMPASS complex|Set1/COMPASS complex|Set1C http://purl.obolibrary.org/obo/GO_0048188 GO:0097111 biolink:BiologicalProcess endoplasmic reticulum-Golgi intermediate compartment organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment. go.json ER-Golgi intermediate compartment organization|ERGIC organization|endoplasmic reticulum-Golgi intermediate compartment organisation|endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis http://purl.obolibrary.org/obo/GO_0097111 GO:0097114 biolink:BiologicalProcess NMDA glutamate receptor clustering The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane. go.json N-methyl-D-aspartate receptor clustering|NMDA receptor clustering http://purl.obolibrary.org/obo/GO_0097114 GO:0048187 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048187 GO:0048186 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048186 GO:0097113 biolink:BiologicalProcess AMPA glutamate receptor clustering The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane. go.json AMPA receptor clustering|alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering http://purl.obolibrary.org/obo/GO_0097113 GO:0000204 biolink:BiologicalProcess obsolete activation of MAPKK during sporulation (sensu Saccharomyces) OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). go.json activation of MAPKK during sporulation (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000204 GO:0048185 biolink:MolecularActivity activin binding Binding to activin, a dimer of inhibin-beta subunits. go.json http://purl.obolibrary.org/obo/GO_0048185 GO:0000203 biolink:BiologicalProcess obsolete activation of MAPKKK during sporulation (sensu Saccharomyces) OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). go.json activation of MAPKKK during sporulation (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000203 GO:0048184 biolink:MolecularActivity obsolete follistatin binding OBSOLETE. Binding to the peptide hormone follistatin. go.json follistatin binding True http://purl.obolibrary.org/obo/GO_0048184 GO:0000202 biolink:BiologicalProcess obsolete MAPKKK cascade during sporulation (sensu Saccharomyces) OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). go.json MAPKKK cascade during sporulation (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000202 GO:0048183 biolink:CellularComponent activin AB complex A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B. go.json inhibin beta-A|inhibin beta-B http://purl.obolibrary.org/obo/GO_0048183 GO:0097110 biolink:MolecularActivity scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. go.json http://purl.obolibrary.org/obo/GO_0097110 GO:0000201 biolink:BiologicalProcess obsolete MAPK import into nucleus involved in cell wall organization or biogenesis OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis. go.json MAPK import into nucleus involved in cell wall biogenesis|MAPK import into nucleus involved in cell wall integrity|cell wall biogenesis, MAPK import into nucleus|cell wall biogenesis, nuclear translocation of MAPK|nuclear translocation of MAPK involved in cell wall biogenesis|nuclear translocation of MAPK involved in cell wall integrity True http://purl.obolibrary.org/obo/GO_0000201 GO:0048182 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048182 GO:0014849 biolink:BiologicalProcess ureter smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. go.json http://purl.obolibrary.org/obo/GO_0014849 GO:0014848 biolink:BiologicalProcess urinary tract smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. go.json http://purl.obolibrary.org/obo/GO_0014848 GO:0014847 biolink:BiologicalProcess proximal stomach smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach. go.json http://purl.obolibrary.org/obo/GO_0014847 GO:0014846 biolink:BiologicalProcess esophagus smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract. go.json oesophagus smooth muscle contraction http://purl.obolibrary.org/obo/GO_0014846 GO:1903589 biolink:BiologicalProcess positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. go.json activation of blood vessel endothelial cell proliferation during sprouting angiogenesis|activation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|up regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|up regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|up-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|up-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|upregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|upregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis http://purl.obolibrary.org/obo/GO_1903589 GO:1903588 biolink:BiologicalProcess negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. go.json down regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|down regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|down-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|down-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|downregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis|downregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|inhibition of blood vessel endothelial cell proliferation during sprouting angiogenesis|inhibition of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|negative regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis http://purl.obolibrary.org/obo/GO_1903588 GO:1903587 biolink:BiologicalProcess regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. go.json regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis http://purl.obolibrary.org/obo/GO_1903587 GO:1903586 biolink:BiologicalProcess positive regulation of histone deubiquitination Any process that activates or increases the frequency, rate or extent of histone deubiquitination. go.json activation of histone deubiquitination|activation of histone deubiquitinylation|activation of histone deubiquitylation|positive regulation of histone deubiquitinylation|positive regulation of histone deubiquitylation|up regulation of histone deubiquitination|up regulation of histone deubiquitinylation|up regulation of histone deubiquitylation|up-regulation of histone deubiquitination|up-regulation of histone deubiquitinylation|up-regulation of histone deubiquitylation|upregulation of histone deubiquitination|upregulation of histone deubiquitinylation|upregulation of histone deubiquitylation http://purl.obolibrary.org/obo/GO_1903586 GO:1903585 biolink:BiologicalProcess negative regulation of histone deubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination. go.json down regulation of histone deubiquitination|down regulation of histone deubiquitinylation|down regulation of histone deubiquitylation|down-regulation of histone deubiquitination|down-regulation of histone deubiquitinylation|down-regulation of histone deubiquitylation|downregulation of histone deubiquitination|downregulation of histone deubiquitinylation|downregulation of histone deubiquitylation|inhibition of histone deubiquitination|inhibition of histone deubiquitinylation|inhibition of histone deubiquitylation|negative regulation of histone deubiquitinylation|negative regulation of histone deubiquitylation http://purl.obolibrary.org/obo/GO_1903585 GO:0014841 biolink:BiologicalProcess skeletal muscle satellite cell proliferation The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. go.json http://purl.obolibrary.org/obo/GO_0014841 GO:1903595 biolink:BiologicalProcess positive regulation of histamine secretion by mast cell Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell. go.json activation of histamine secretion by mast cell|up regulation of histamine secretion by mast cell|up-regulation of histamine secretion by mast cell|upregulation of histamine secretion by mast cell http://purl.obolibrary.org/obo/GO_1903595 GO:1903594 biolink:BiologicalProcess negative regulation of histamine secretion by mast cell Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell. go.json down regulation of histamine secretion by mast cell|down-regulation of histamine secretion by mast cell|downregulation of histamine secretion by mast cell|inhibition of histamine secretion by mast cell http://purl.obolibrary.org/obo/GO_1903594 GO:1903593 biolink:BiologicalProcess regulation of histamine secretion by mast cell Any process that modulates the frequency, rate or extent of histamine secretion by mast cell. go.json http://purl.obolibrary.org/obo/GO_1903593 GO:1903592 biolink:BiologicalProcess positive regulation of lysozyme activity Any process that activates or increases the frequency, rate or extent of lysozyme activity. go.json activation of 1,4-N-acetylmuramidase activity|activation of L-7001|activation of N,O-diacetylmuramidase activity|activation of PR1-lysozyme|activation of globulin G|activation of globulin G1|activation of lysozyme activity|activation of lysozyme g|activation of mucopeptide N-acetylmuramoylhydrolase activity|activation of mucopeptide glucohydrolase activity|activation of muramidase activity|activation of peptidoglycan N-acetylmuramoylhydrolase activity|positive regulation of 1,4-N-acetylmuramidase activity|positive regulation of L-7001|positive regulation of N,O-diacetylmuramidase activity|positive regulation of PR1-lysozyme|positive regulation of globulin G|positive regulation of globulin G1|positive regulation of lysozyme g|positive regulation of mucopeptide N-acetylmuramoylhydrolase activity|positive regulation of mucopeptide glucohydrolase activity|positive regulation of muramidase activity|positive regulation of peptidoglycan N-acetylmuramoylhydrolase activity|up regulation of 1,4-N-acetylmuramidase activity|up regulation of L-7001|up regulation of N,O-diacetylmuramidase activity|up regulation of PR1-lysozyme|up regulation of globulin G|up regulation of globulin G1|up regulation of lysozyme activity|up regulation of lysozyme g|up regulation of mucopeptide N-acetylmuramoylhydrolase activity|up regulation of mucopeptide glucohydrolase activity|up regulation of muramidase activity|up regulation of peptidoglycan N-acetylmuramoylhydrolase activity|up-regulation of 1,4-N-acetylmuramidase activity|up-regulation of L-7001|up-regulation of N,O-diacetylmuramidase activity|up-regulation of PR1-lysozyme|up-regulation of globulin G|up-regulation of globulin G1|up-regulation of lysozyme activity|up-regulation of lysozyme g|up-regulation of mucopeptide N-acetylmuramoylhydrolase activity|up-regulation of mucopeptide glucohydrolase activity|up-regulation of muramidase activity|up-regulation of peptidoglycan N-acetylmuramoylhydrolase activity|upregulation of 1,4-N-acetylmuramidase activity|upregulation of L-7001|upregulation of N,O-diacetylmuramidase activity|upregulation of PR1-lysozyme|upregulation of globulin G|upregulation of globulin G1|upregulation of lysozyme activity|upregulation of lysozyme g|upregulation of mucopeptide N-acetylmuramoylhydrolase activity|upregulation of mucopeptide glucohydrolase activity|upregulation of muramidase activity|upregulation of peptidoglycan N-acetylmuramoylhydrolase activity http://purl.obolibrary.org/obo/GO_1903592 gocheck_do_not_annotate GO:1903591 biolink:BiologicalProcess negative regulation of lysozyme activity Any process that stops, prevents or reduces the frequency, rate or extent of lysozyme activity. go.json down regulation of 1,4-N-acetylmuramidase activity|down regulation of L-7001|down regulation of N,O-diacetylmuramidase activity|down regulation of PR1-lysozyme|down regulation of globulin G|down regulation of globulin G1|down regulation of lysozyme activity|down regulation of lysozyme g|down regulation of mucopeptide N-acetylmuramoylhydrolase activity|down regulation of mucopeptide glucohydrolase activity|down regulation of muramidase activity|down regulation of peptidoglycan N-acetylmuramoylhydrolase activity|down-regulation of 1,4-N-acetylmuramidase activity|down-regulation of L-7001|down-regulation of N,O-diacetylmuramidase activity|down-regulation of PR1-lysozyme|down-regulation of globulin G|down-regulation of globulin G1|down-regulation of lysozyme activity|down-regulation of lysozyme g|down-regulation of mucopeptide N-acetylmuramoylhydrolase activity|down-regulation of mucopeptide glucohydrolase activity|down-regulation of muramidase activity|down-regulation of peptidoglycan N-acetylmuramoylhydrolase activity|downregulation of 1,4-N-acetylmuramidase activity|downregulation of L-7001|downregulation of N,O-diacetylmuramidase activity|downregulation of PR1-lysozyme|downregulation of globulin G|downregulation of globulin G1|downregulation of lysozyme activity|downregulation of lysozyme g|downregulation of mucopeptide N-acetylmuramoylhydrolase activity|downregulation of mucopeptide glucohydrolase activity|downregulation of muramidase activity|downregulation of peptidoglycan N-acetylmuramoylhydrolase activity|inhibition of 1,4-N-acetylmuramidase activity|inhibition of L-7001|inhibition of N,O-diacetylmuramidase activity|inhibition of PR1-lysozyme|inhibition of globulin G|inhibition of globulin G1|inhibition of lysozyme activity|inhibition of lysozyme g|inhibition of mucopeptide N-acetylmuramoylhydrolase activity|inhibition of mucopeptide glucohydrolase activity|inhibition of muramidase activity|inhibition of peptidoglycan N-acetylmuramoylhydrolase activity|negative regulation of 1,4-N-acetylmuramidase activity|negative regulation of L-7001|negative regulation of N,O-diacetylmuramidase activity|negative regulation of PR1-lysozyme|negative regulation of globulin G|negative regulation of globulin G1|negative regulation of lysozyme g|negative regulation of mucopeptide N-acetylmuramoylhydrolase activity|negative regulation of mucopeptide glucohydrolase activity|negative regulation of muramidase activity|negative regulation of peptidoglycan N-acetylmuramoylhydrolase activity http://purl.obolibrary.org/obo/GO_1903591 gocheck_do_not_annotate GO:0014845 biolink:BiologicalProcess stomach body smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined. go.json http://purl.obolibrary.org/obo/GO_0014845 GO:1903590 biolink:BiologicalProcess regulation of lysozyme activity Any process that modulates the frequency, rate or extent of lysozyme activity. go.json regulation of 1,4-N-acetylmuramidase activity|regulation of L-7001|regulation of N,O-diacetylmuramidase activity|regulation of PR1-lysozyme|regulation of globulin G|regulation of globulin G1|regulation of lysozyme g|regulation of mucopeptide N-acetylmuramoylhydrolase activity|regulation of mucopeptide glucohydrolase activity|regulation of muramidase activity|regulation of peptidoglycan N-acetylmuramoylhydrolase activity http://purl.obolibrary.org/obo/GO_1903590 gocheck_do_not_annotate GO:0014844 biolink:BiologicalProcess myoblast proliferation involved in skeletal muscle regeneration The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014844 GO:0014843 biolink:BiologicalProcess growth factor dependent regulation of skeletal muscle satellite cell proliferation Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. go.json http://purl.obolibrary.org/obo/GO_0014843 GO:0014842 biolink:BiologicalProcess regulation of skeletal muscle satellite cell proliferation Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0014842 GO:0048192 biolink:MolecularActivity obsolete peptide antigen stabilization activity OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell. go.json peptide antigen stabilization activity True http://purl.obolibrary.org/obo/GO_0048192 GO:0000208 biolink:BiologicalProcess obsolete MAPK import into nucleus involved in osmosensory signaling pathway OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing. go.json MAPK import into nucleus during osmolarity sensing|MAPK import into nucleus involved in osmosensory signalling pathway|nuclear translocation of MAPK during osmolarity sensing|nuclear translocation of MAPK involved in osmosensory signaling pathway|nuclear translocation of MAPK involved in osmosensory signalling pathway|osmolarity sensing, MAPK import into nucleus|osmolarity sensing, nuclear translocation of MAPK True http://purl.obolibrary.org/obo/GO_0000208 GO:0097119 biolink:BiologicalProcess postsynaptic density protein 95 clustering The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. go.json Dlg4 clustering|PSD-95 clustering|post-synaptic density protein 95 clustering http://purl.obolibrary.org/obo/GO_0097119 GO:0048191 biolink:MolecularActivity obsolete peptide stabilization activity OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. go.json peptide stabilization activity True http://purl.obolibrary.org/obo/GO_0048191 GO:0000207 biolink:BiologicalProcess obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces) OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). go.json nuclear translocation of MAPK during sporulation (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000207 GO:0048190 biolink:BiologicalProcess wing disc dorsal/ventral pattern formation The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing. go.json wing disc dorsal-ventral pattern formation|wing disc dorsoventral pattern formation http://purl.obolibrary.org/obo/GO_0048190 GO:0000206 biolink:BiologicalProcess obsolete inactivation of MAPK during sporulation (sensu Saccharomyces) OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). go.json inactivation of MAPK during sporulation (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000206 GO:0000205 biolink:BiologicalProcess obsolete activation of MAPK during sporulation (sensu Saccharomyces) OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). go.json activation of MAPK during sporulation (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000205 GO:0097116 biolink:BiologicalProcess gephyrin clustering involved in postsynaptic density assembly The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. go.json Geph clustering http://purl.obolibrary.org/obo/GO_0097116 GO:0097115 biolink:BiologicalProcess neurexin clustering involved in presynaptic membrane assembly The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals. go.json Nrxn clustering|neurexin clustering|presynaptic neurexin clustering http://purl.obolibrary.org/obo/GO_0097115 GO:0097118 biolink:BiologicalProcess neuroligin clustering involved in postsynaptic membrane assembly The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons. go.json Nlgn clustering|neuroligin clustering|postsynaptic neuroligin clustering http://purl.obolibrary.org/obo/GO_0097118 GO:0097117 biolink:BiologicalProcess guanylate kinase-associated protein clustering The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons. go.json GKAP clustering http://purl.obolibrary.org/obo/GO_0097117 GO:0000209 biolink:BiologicalProcess protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. go.json polyubiquitin|protein polyubiquitinylation|protein polyubiquitylation http://purl.obolibrary.org/obo/GO_0000209 GO:0000211 biolink:MolecularActivity obsolete protein degradation tagging activity OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction. go.json protein degradation tagging activity True http://purl.obolibrary.org/obo/GO_0000211 GO:0097123 biolink:CellularComponent cyclin A1-CDK2 complex A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097123 GO:0000210 biolink:MolecularActivity NAD+ diphosphatase activity Catalysis of the reaction: NAD+ + H2O = AMP + NMN. EC:3.6.1.22|MetaCyc:NADPYROPHOSPHAT-RXN|RHEA:11800 go.json NAD diphosphatase activity|NAD pyrophosphatase activity|NAD(+) pyrophosphatase activity|NAD+ phosphohydrolase activity|NAD+ pyrophosphatase activity|NADP pyrophosphatase activity|nicotinamide adenine dinucleotide pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0000210 GO:0048199 biolink:BiologicalProcess vesicle targeting, to, from or within Golgi The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. go.json Golgi vesicle targeting|dictyosome vesicle targeting|vesicle targeting, to, from or within dictyosome http://purl.obolibrary.org/obo/GO_0048199 GO:0097122 biolink:CellularComponent cyclin A2-CDK1 complex A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097122 GO:0048198 biolink:BiologicalProcess Golgi vesicle bud deformation and release The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released. go.json Golgi-derived vesicle bud deformation and release|dictyosome vesicle bud deformation http://purl.obolibrary.org/obo/GO_0048198 GO:0097125 biolink:CellularComponent cyclin B1-CDK1 complex A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097125 GO:0048197 biolink:BiologicalProcess Golgi membrane coat protein complex assembly The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat. go.json Golgi apparatus membrane coat protein complex assembly|Golgi membrane bud coat oligomerisation|dictyosome membrane binding by cytosolic coat proteins|dictyosome membrane bud coat oligomerisation http://purl.obolibrary.org/obo/GO_0048197 GO:0097124 biolink:CellularComponent cyclin A2-CDK2 complex A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097124 GO:0000215 biolink:MolecularActivity tRNA 2'-phosphotransferase activity Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. EC:2.7.1.160|MetaCyc:2.7.1.160-RXN|RHEA:23324 go.json 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity|2'-phospho-tRNA:NAD+ phosphotransferase activity|2'-phosphotransferase activity|Tpt1|Tpt1p|yeast 2'-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0000215 goslim_chembl GO:0048196 biolink:CellularComponent obsolete plant extracellular matrix OBSOLETE. The matrix external to the plant plasma membrane, composed of the cell wall and middle lamella. go.json middle lamella-containing extracellular matrix|plant extracellular matrix True http://purl.obolibrary.org/obo/GO_0048196 GO:0000214 biolink:CellularComponent tRNA-intron endonuclease complex A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. go.json SEN complex|tRNA splicing endonuclease complex http://purl.obolibrary.org/obo/GO_0000214 GO:0048195 biolink:BiologicalProcess Golgi membrane priming complex assembly The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex. go.json formation of Golgi membrane priming complex|formation of dictyosome membrane priming complex http://purl.obolibrary.org/obo/GO_0048195 GO:0048194 biolink:BiologicalProcess Golgi vesicle budding The evagination of the Golgi membrane, resulting in formation of a vesicle. go.json Golgi-derived vesicle budding|dictyosome vesicle budding http://purl.obolibrary.org/obo/GO_0048194 GO:0000213 biolink:MolecularActivity tRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. EC:4.6.1.16|MetaCyc:3.1.27.9-RXN go.json tRNA splicing endonuclease activity|tRNA-intron endoribonuclease activity http://purl.obolibrary.org/obo/GO_0000213 GO:0097121 biolink:CellularComponent cyclin A1-CDK1 complex A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097121 GO:0048193 biolink:BiologicalProcess Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. go.json Golgi-derived vesicle transport http://purl.obolibrary.org/obo/GO_0048193 goslim_yeast GO:0097120 biolink:BiologicalProcess receptor localization to synapse Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. go.json receptor localisation to synapse http://purl.obolibrary.org/obo/GO_0097120 GO:0000212 biolink:BiologicalProcess meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. go.json meiotic spindle organisation|meiotic spindle organization and biogenesis|meiotic spindle stabilization|spindle organization during meiosis http://purl.obolibrary.org/obo/GO_0000212 GO:0014859 biolink:BiologicalProcess negative regulation of skeletal muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0014859 GO:0014858 biolink:BiologicalProcess positive regulation of skeletal muscle cell proliferation Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0014858 GO:0014857 biolink:BiologicalProcess regulation of skeletal muscle cell proliferation Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0014857 GO:1903599 biolink:BiologicalProcess positive regulation of autophagy of mitochondrion Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy. go.json activation of mitochondrion degradation|activation of mitophagy|positive regulation of mitochondrial degradation|up regulation of mitochondrion degradation|up regulation of mitophagy|up-regulation of mitochondrion degradation|up-regulation of mitophagy|upregulation of mitochondrion degradation|upregulation of mitophagy http://purl.obolibrary.org/obo/GO_1903599 GO:1903598 biolink:BiologicalProcess positive regulation of gap junction assembly Any process that activates or increases the frequency, rate or extent of gap junction assembly. go.json activation of gap junction assembly|up regulation of gap junction assembly|up-regulation of gap junction assembly|upregulation of gap junction assembly http://purl.obolibrary.org/obo/GO_1903598 GO:1903597 biolink:BiologicalProcess negative regulation of gap junction assembly Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly. go.json down regulation of gap junction assembly|down-regulation of gap junction assembly|downregulation of gap junction assembly|inhibition of gap junction assembly http://purl.obolibrary.org/obo/GO_1903597 GO:1903596 biolink:BiologicalProcess regulation of gap junction assembly Any process that modulates the frequency, rate or extent of gap junction assembly. go.json http://purl.obolibrary.org/obo/GO_1903596 GO:0014852 biolink:BiologicalProcess regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system. go.json http://purl.obolibrary.org/obo/GO_0014852 GO:0014850 biolink:BiologicalProcess response to muscle activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. go.json http://purl.obolibrary.org/obo/GO_0014850 GO:0014856 biolink:BiologicalProcess skeletal muscle cell proliferation The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0014856 GO:0014855 biolink:BiologicalProcess striated muscle cell proliferation The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. go.json http://purl.obolibrary.org/obo/GO_0014855 GO:0014854 biolink:BiologicalProcess response to inactivity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. go.json http://purl.obolibrary.org/obo/GO_0014854 GO:0014853 biolink:BiologicalProcess regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. go.json regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0014853 GO:0000219 biolink:CellularComponent obsolete vacuolar hydrogen-transporting ATPase OBSOLETE. (Was not defined before being made obsolete). go.json V-ATPase|vacuolar hydrogen-transporting ATPase True http://purl.obolibrary.org/obo/GO_0000219 GO:0000218 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000218 GO:0000217 biolink:MolecularActivity DNA secondary structure binding Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction. go.json http://purl.obolibrary.org/obo/GO_0000217 GO:0000216 biolink:BiologicalProcess obsolete M/G1 transition of mitotic cell cycle OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle. go.json M/G1 transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0000216 GO:0097127 biolink:CellularComponent cyclin B3-CDK2 complex A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097127 GO:0097126 biolink:CellularComponent cyclin B2-CDK1 complex A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097126 GO:0097129 biolink:CellularComponent cyclin D2-CDK4 complex A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097129 GO:0097128 biolink:CellularComponent cyclin D1-CDK4 complex A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097128 GO:0014827 biolink:BiologicalProcess intestine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. go.json http://purl.obolibrary.org/obo/GO_0014827 GO:0014826 biolink:BiologicalProcess vein smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds. go.json http://purl.obolibrary.org/obo/GO_0014826 GO:0014825 biolink:BiologicalProcess stomach fundus smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch. go.json http://purl.obolibrary.org/obo/GO_0014825 GO:0014824 biolink:BiologicalProcess artery smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart. go.json http://purl.obolibrary.org/obo/GO_0014824 GO:0014829 biolink:BiologicalProcess vascular associated smooth muscle contraction A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. go.json vascular smooth muscle contraction http://purl.obolibrary.org/obo/GO_0014829 GO:0014828 biolink:BiologicalProcess distal stomach smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus. go.json http://purl.obolibrary.org/obo/GO_0014828 GO:0014823 biolink:BiologicalProcess response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. go.json response to exercise http://purl.obolibrary.org/obo/GO_0014823 GO:0014822 biolink:BiologicalProcess detection of wounding The series of events by which an injury stimulus is received and converted into a molecular signal. go.json detection of injury http://purl.obolibrary.org/obo/GO_0014822 GO:0014821 biolink:BiologicalProcess phasic smooth muscle contraction A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. go.json http://purl.obolibrary.org/obo/GO_0014821 GO:0014820 biolink:BiologicalProcess tonic smooth muscle contraction A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction. go.json http://purl.obolibrary.org/obo/GO_0014820 GO:0097101 biolink:BiologicalProcess blood vessel endothelial cell fate specification The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. go.json http://purl.obolibrary.org/obo/GO_0097101 GO:0097100 biolink:MolecularActivity supercoiled DNA binding Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. go.json http://purl.obolibrary.org/obo/GO_0097100 GO:0097103 biolink:BiologicalProcess endothelial stalk cell fate specification The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout. go.json angiogenic stalk cell fate specification http://purl.obolibrary.org/obo/GO_0097103 GO:0097102 biolink:BiologicalProcess endothelial tip cell fate specification The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels. go.json angiogenic tip cell fate specification http://purl.obolibrary.org/obo/GO_0097102 GO:0014838 biolink:BiologicalProcess myoblast fate specification involved in skeletal muscle regeneration The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014838 GO:0014837 biolink:BiologicalProcess myoblast fate determination involved in skeletal muscle regeneration The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014837 GO:0014836 biolink:BiologicalProcess myoblast fate commitment involved in skeletal muscle regeneration The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014836 GO:0014835 biolink:BiologicalProcess myoblast differentiation involved in skeletal muscle regeneration The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014835 GO:0014839 biolink:BiologicalProcess myoblast migration involved in skeletal muscle regeneration The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json mononucleate cell migration involved in skeletal muscle regeneration http://purl.obolibrary.org/obo/GO_0014839 GO:0014830 biolink:BiologicalProcess arteriole smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries. go.json http://purl.obolibrary.org/obo/GO_0014830 GO:0014834 biolink:BiologicalProcess skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells. go.json satellite cell compartment self-renewal involved in skeletal muscle regeneration|satellite cell population maintenance|satellite cell self-renewal http://purl.obolibrary.org/obo/GO_0014834 GO:0014833 biolink:BiologicalProcess skeletal muscle satellite stem cell asymmetric division The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool. go.json satellite cell asymmetric division http://purl.obolibrary.org/obo/GO_0014833 GO:0014832 biolink:BiologicalProcess urinary bladder smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract. go.json http://purl.obolibrary.org/obo/GO_0014832 GO:0014831 biolink:BiologicalProcess gastro-intestinal system smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). go.json http://purl.obolibrary.org/obo/GO_0014831 GO:0097109 biolink:MolecularActivity neuroligin family protein binding Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. go.json http://purl.obolibrary.org/obo/GO_0097109 GO:0097108 biolink:MolecularActivity hedgehog family protein binding Binding to a member of the hedgehog protein family, signaling proteins involved in development. go.json http://purl.obolibrary.org/obo/GO_0097108 GO:0097105 biolink:BiologicalProcess presynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. go.json pre-synaptic membrane assembly http://purl.obolibrary.org/obo/GO_0097105 goslim_synapse GO:0097104 biolink:BiologicalProcess postsynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). go.json post-synaptic membrane assembly http://purl.obolibrary.org/obo/GO_0097104 goslim_synapse GO:0097107 biolink:BiologicalProcess postsynaptic density assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. go.json PSD assembly|post synaptic density assembly|post-synaptic density assembly http://purl.obolibrary.org/obo/GO_0097107 goslim_synapse GO:0097106 biolink:BiologicalProcess postsynaptic density organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. go.json PSD organization|post synaptic density organization|post-synaptic density organization|postsynaptic density organisation http://purl.obolibrary.org/obo/GO_0097106 GO:0097156 biolink:BiologicalProcess fasciculation of motor neuron axon The collection of motor neuron axons into a bundle of rods, known as a fascicle. go.json http://purl.obolibrary.org/obo/GO_0097156 GO:0097155 biolink:BiologicalProcess fasciculation of sensory neuron axon The collection of sensory neuron axons into a bundle of rods, known as a fascicle. go.json http://purl.obolibrary.org/obo/GO_0097155 GO:0097158 biolink:MolecularActivity pre-mRNA intronic pyrimidine-rich binding Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). go.json pre-messenger RNA intronic pyrimidine-rich binding http://purl.obolibrary.org/obo/GO_0097158 GO:0097157 biolink:MolecularActivity pre-mRNA intronic binding Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA). go.json pre-messenger RNA intronic binding http://purl.obolibrary.org/obo/GO_0097157 GO:0097152 biolink:BiologicalProcess mesenchymal cell apoptotic process Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. go.json mesenchymal cell apoptosis http://purl.obolibrary.org/obo/GO_0097152 GO:0097151 biolink:BiologicalProcess positive regulation of inhibitory postsynaptic potential Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. go.json positive regulation of IPSP|positive regulation of inhibitory post-synaptic membrane potential http://purl.obolibrary.org/obo/GO_0097151 GO:0097154 biolink:BiologicalProcess GABAergic neuron differentiation The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. go.json http://purl.obolibrary.org/obo/GO_0097154 GO:0097153 biolink:MolecularActivity cysteine-type endopeptidase activity involved in apoptotic process Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. Reactome:R-HSA-6800797 go.json caspase activity|metacaspase activity http://purl.obolibrary.org/obo/GO_0097153 GO:0014805 biolink:BiologicalProcess smooth muscle adaptation Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. go.json smooth muscle plasticity http://purl.obolibrary.org/obo/GO_0014805 GO:0014804 biolink:CellularComponent terminal cisterna lumen The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin. go.json http://purl.obolibrary.org/obo/GO_0014804 GO:0014803 biolink:CellularComponent longitudinal sarcoplasmic reticulum lumen The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae. go.json http://purl.obolibrary.org/obo/GO_0014803 GO:0097150 biolink:BiologicalProcess neuronal stem cell population maintenance Any process in by an organism or tissue maintains a population of neuronal stem cells. go.json http://purl.obolibrary.org/obo/GO_0097150 GO:0014802 biolink:CellularComponent terminal cisterna The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release. Wikipedia:Terminal_cisterna go.json http://purl.obolibrary.org/obo/GO_0014802 GO:0014809 biolink:BiologicalProcess regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. go.json http://purl.obolibrary.org/obo/GO_0014809 GO:0014808 biolink:BiologicalProcess release of sequestered calcium ion into cytosol by sarcoplasmic reticulum The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. go.json release of sequestered calcium ion by sarcoplasmic reticulum into cytosol http://purl.obolibrary.org/obo/GO_0014808 GO:0014807 biolink:BiologicalProcess regulation of somitogenesis Any process that modulates the frequency, rate or extent of somitogenesis. go.json http://purl.obolibrary.org/obo/GO_0014807 GO:0014806 biolink:BiologicalProcess smooth muscle hyperplasia A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ. go.json http://purl.obolibrary.org/obo/GO_0014806 GO:0014801 biolink:CellularComponent longitudinal sarcoplasmic reticulum The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae. go.json http://purl.obolibrary.org/obo/GO_0014801 GO:0097159 biolink:MolecularActivity organic cyclic compound binding Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. go.json http://purl.obolibrary.org/obo/GO_0097159 GO:0097167 biolink:BiologicalProcess circadian regulation of translation Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours. go.json regulation of mRNA translation in response to circadian clock http://purl.obolibrary.org/obo/GO_0097167 GO:0097166 biolink:BiologicalProcess lens epithelial cell proliferation The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. go.json http://purl.obolibrary.org/obo/GO_0097166 GO:0097169 biolink:CellularComponent AIM2 inflammasome complex An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0097169 GO:0097168 biolink:BiologicalProcess mesenchymal stem cell proliferation The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json MSC proliferation http://purl.obolibrary.org/obo/GO_0097168 GO:0097163 biolink:MolecularActivity sulfur carrier activity Covalently binding to sulfur and delivering it to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0097163 GO:0097162 biolink:MolecularActivity MADS box domain binding Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs. go.json http://purl.obolibrary.org/obo/GO_0097162 GO:0097165 biolink:CellularComponent nuclear stress granule A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. go.json http://purl.obolibrary.org/obo/GO_0097165 GO:0097164 biolink:BiologicalProcess ammonium ion metabolic process The chemical reactions and pathways involving the ammonium ion. go.json ammonium ion metabolism|ammonium metabolic process http://purl.obolibrary.org/obo/GO_0097164 GO:0014816 biolink:BiologicalProcess skeletal muscle satellite cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a satellite cell. go.json http://purl.obolibrary.org/obo/GO_0014816 GO:0014815 biolink:BiologicalProcess obsolete initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration OBSOLETE. Signaling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. go.json True http://purl.obolibrary.org/obo/GO_0014815 GO:0097161 biolink:MolecularActivity DH domain binding Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. go.json http://purl.obolibrary.org/obo/GO_0097161 GO:0014814 biolink:BiologicalProcess axon regeneration at neuromuscular junction The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones. go.json http://purl.obolibrary.org/obo/GO_0014814 GO:0097160 biolink:MolecularActivity polychlorinated biphenyl binding Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings. go.json PCB binding|polychlorobiphenyl binding http://purl.obolibrary.org/obo/GO_0097160 GO:0014813 biolink:BiologicalProcess skeletal muscle satellite cell commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell. go.json http://purl.obolibrary.org/obo/GO_0014813 GO:0014819 biolink:BiologicalProcess regulation of skeletal muscle contraction Any process that modulates the frequency, rate or extent of skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014819 GO:0014818 biolink:BiologicalProcess skeletal muscle satellite cell fate determination The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0014818 GO:0014817 biolink:BiologicalProcess skeletal muscle satellite cell fate specification The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0014817 GO:0014812 biolink:BiologicalProcess muscle cell migration The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0014812 GO:0014811 biolink:BiologicalProcess negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. go.json http://purl.obolibrary.org/obo/GO_0014811 GO:0014810 biolink:BiologicalProcess positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. go.json http://purl.obolibrary.org/obo/GO_0014810 GO:0097134 biolink:CellularComponent cyclin E1-CDK2 complex A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097134 GO:0097133 biolink:CellularComponent cyclin D3-CDK6 complex A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097133 GO:0097136 biolink:CellularComponent Bcl-2 family protein complex A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. go.json http://purl.obolibrary.org/obo/GO_0097136 GO:0097135 biolink:CellularComponent cyclin E2-CDK2 complex A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097135 GO:0097130 biolink:CellularComponent cyclin D3-CDK4 complex A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097130 GO:0097132 biolink:CellularComponent cyclin D2-CDK6 complex A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097132 GO:0097131 biolink:CellularComponent cyclin D1-CDK6 complex A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. go.json http://purl.obolibrary.org/obo/GO_0097131 GO:0097138 biolink:CellularComponent BAD-BCL-2 complex A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097138 GO:0097137 biolink:CellularComponent BAD-BCL-xl complex A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097137 GO:0097139 biolink:CellularComponent BID-BCL-2 complex A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097139 GO:0097145 biolink:CellularComponent BAK complex An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097145 GO:0097144 biolink:CellularComponent BAX complex An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097144 GO:0097147 biolink:CellularComponent NOXA-BCL-2 complex A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097147 GO:0097146 biolink:CellularComponent NOXA-BCL-xl complex A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097146 GO:0097141 biolink:CellularComponent BIM-BCL-2 complex A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097141 GO:0097140 biolink:CellularComponent BIM-BCL-xl complex A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097140 GO:0097143 biolink:CellularComponent PUMA-BCL-xl complex A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097143 GO:0097142 biolink:CellularComponent PUMA-BCL-2 complex A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097142 GO:0097149 biolink:CellularComponent centralspindlin complex A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals). go.json http://purl.obolibrary.org/obo/GO_0097149 GO:0097148 biolink:CellularComponent BCL-2 complex A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators. go.json http://purl.obolibrary.org/obo/GO_0097148 GO:0048101 biolink:MolecularActivity calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin. go.json calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity|calcium- and calmodulin-regulated cGMP phosphodiesterase activity|calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity|calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity|calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0048101 GO:0000167 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000167 GO:0048100 biolink:BiologicalProcess wing disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing. go.json http://purl.obolibrary.org/obo/GO_0048100 GO:0000166 biolink:MolecularActivity nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0000166 goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant GO:0000165 biolink:BiologicalProcess MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. Wikipedia:MAPK_cascade|Wikipedia:Mitogen-activated_protein_kinase go.json ERK/MAPK cascade|MAP kinase cascade|MAP kinase kinase kinase cascade|MAPK signal transduction|MAPK signaling|MAPK signalling|MAPKKK cascade|MAPKKK cascade during sporulation|mitogen-activated protein kinase cascade http://purl.obolibrary.org/obo/GO_0000165 GO:1903509 biolink:BiologicalProcess liposaccharide metabolic process The chemical reactions and pathways involving liposaccharide. go.json liposaccharide metabolism http://purl.obolibrary.org/obo/GO_1903509 GO:0000164 biolink:CellularComponent protein phosphatase type 1 complex A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. go.json http://purl.obolibrary.org/obo/GO_0000164 GO:1903508 biolink:BiologicalProcess obsolete positive regulation of nucleic acid-templated transcription OBSOLETE. Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription. go.json activation of nucleic acid-templated transcription|up regulation of nucleic acid-templated transcription|up-regulation of nucleic acid-templated transcription|upregulation of nucleic acid-templated transcription True http://purl.obolibrary.org/obo/GO_1903508 GO:1903507 biolink:BiologicalProcess obsolete negative regulation of nucleic acid-templated transcription OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription. go.json down regulation of nucleic acid-templated transcription|down-regulation of nucleic acid-templated transcription|downregulation of nucleic acid-templated transcription|inhibition of nucleic acid-templated transcription True http://purl.obolibrary.org/obo/GO_1903507 GO:1903506 biolink:BiologicalProcess obsolete regulation of nucleic acid-templated transcription OBSOLETE. Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription. go.json True http://purl.obolibrary.org/obo/GO_1903506 GO:0000169 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000169 GO:1903505 biolink:BiologicalProcess obsolete regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle OBSOLETE. Any process that modulates the frequency, rate or extent of establishment of actomyosin contractile ring localization involved in mitotic cell cycle. go.json True http://purl.obolibrary.org/obo/GO_1903505 GO:0000168 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000168 GO:0048109 biolink:BiologicalProcess peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water. RESID:AA0344 go.json http://purl.obolibrary.org/obo/GO_0048109 gocheck_do_not_annotate GO:1903504 biolink:BiologicalProcess regulation of mitotic spindle checkpoint Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. go.json regulation of mitotic cell cycle spindle checkpoint http://purl.obolibrary.org/obo/GO_1903504 gocheck_do_not_manually_annotate GO:0048108 biolink:BiologicalProcess peptide cross-linking via 4-amino-3-isothiazolidinone The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue. go.json http://purl.obolibrary.org/obo/GO_0048108 gocheck_do_not_annotate GO:1903503 biolink:CellularComponent ATPase inhibitor complex A protein complex which is capable of ATPase inhibitor activity. go.json http://purl.obolibrary.org/obo/GO_1903503 GO:1903502 biolink:CellularComponent translation repressor complex A protein complex which is capable of translation repressor activity. go.json http://purl.obolibrary.org/obo/GO_1903502 GO:0048107 biolink:BiologicalProcess 4-amino-3-isothiazolidinone biosynthetic process The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively. go.json 4-amino-3-isothiazolidinone anabolism|4-amino-3-isothiazolidinone biosynthesis|4-amino-3-isothiazolidinone formation|4-amino-3-isothiazolidinone synthesis http://purl.obolibrary.org/obo/GO_0048107 GO:0048106 biolink:BiologicalProcess establishment of thoracic bristle planar orientation Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction. go.json establishment of body bristle planar orientation http://purl.obolibrary.org/obo/GO_0048106 GO:1903501 biolink:BiologicalProcess positive regulation of mitotic actomyosin contractile ring assembly Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring assembly. go.json activation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|activation of contractile ring assembly involved in mitotic cytokinesis|activation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|activation of mitotic actomyosin contractile ring assembly|positive regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|positive regulation of contractile ring assembly involved in mitotic cytokinesis|positive regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|positive regulation of mitotic cytokinesis, actomyosin contractile ring assembly|up regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|up regulation of contractile ring assembly involved in mitotic cytokinesis|up regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|up regulation of mitotic actomyosin contractile ring assembly|up-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|up-regulation of contractile ring assembly involved in mitotic cytokinesis|up-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|up-regulation of mitotic actomyosin contractile ring assembly|upregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|upregulation of contractile ring assembly involved in mitotic cytokinesis|upregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|upregulation of mitotic actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_1903501 GO:1903500 biolink:BiologicalProcess negative regulation of mitotic actomyosin contractile ring assembly Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly. go.json down regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|down regulation of contractile ring assembly involved in mitotic cytokinesis|down regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|down regulation of mitotic actomyosin contractile ring assembly|down-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|down-regulation of contractile ring assembly involved in mitotic cytokinesis|down-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|down-regulation of mitotic actomyosin contractile ring assembly|downregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|downregulation of contractile ring assembly involved in mitotic cytokinesis|downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|downregulation of mitotic actomyosin contractile ring assembly|inhibition of actomyosin contractile ring assembly involved in cytokinesis after mitosis|inhibition of contractile ring assembly involved in mitotic cytokinesis|inhibition of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|inhibition of mitotic actomyosin contractile ring assembly|negative regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|negative regulation of contractile ring assembly involved in mitotic cytokinesis|negative regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|negative regulation of mitotic cytokinesis, actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_1903500 GO:0048105 biolink:BiologicalProcess establishment of body hair planar orientation Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface. go.json http://purl.obolibrary.org/obo/GO_0048105 GO:0000163 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000163 GO:0000162 biolink:BiologicalProcess tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. MetaCyc:TRPSYN-PWY go.json aromatic amino acid family biosynthetic process, anthranilate pathway|tryptophan anabolism|tryptophan biosynthesis|tryptophan formation|tryptophan synthesis http://purl.obolibrary.org/obo/GO_0000162 GO:0048104 biolink:BiologicalProcess establishment of body hair or bristle planar orientation Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project. go.json http://purl.obolibrary.org/obo/GO_0048104 GO:0000161 biolink:BiologicalProcess osmosensory signaling MAPK cascade The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K. go.json High Osmolarity Glycerol (HOG) MAPK pathway|Hog1 MAPK pathway|Hog1/Sty1 stress-activated MAPK cascade|MAPK cascade involved in osmosensory signaling pathway|MAPKKK cascade during osmolarity sensing|MAPKKK cascade involved in osmosensory signaling pathway|MAPKKK cascade involved in osmosensory signalling pathway|activation of MAPK activity involved in osmosensory signaling pathway|activation of MAPKK activity during osmolarity sensing|activation of MAPKK activity involved in osmosensory signaling pathway|activation of MAPKKK activity during osmolarity sensing|activation of MAPKKK activity involved in osmosensory signaling pathway|activation of Pbs2 kinase|inactivation of MAPK activity involved in osmosensory signaling pathway|osmolarity sensing, MAPKKK cascade|osmolarity sensing, activation of MAP kinase kinase activity|osmolarity sensing, activation of MAP kinase kinase kinase activity|osmolarity sensing, activation of MAPK activity|osmolarity sensing, activation of MAPKK activity|osmolarity sensing, activation of MAPKKK activity|termination of MAPK activity during osmolarity sensing http://purl.obolibrary.org/obo/GO_0000161 GO:0048103 biolink:BiologicalProcess somatic stem cell division The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. go.json somatic stem cell renewal http://purl.obolibrary.org/obo/GO_0048103 GO:0048102 biolink:BiologicalProcess autophagic cell death A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells. go.json autophagic death|autosis|programmed cell death by autophagy|programmed cell death by macroautophagy|type II programmed cell death http://purl.obolibrary.org/obo/GO_0048102 GO:0000160 biolink:BiologicalProcess phosphorelay signal transduction system A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. go.json histidyl-aspartyl phosphorelay http://purl.obolibrary.org/obo/GO_0000160 goslim_metagenomics GO:0000178 biolink:CellularComponent exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. go.json exosome (ribonucleasease complex)|exosome multienzyme ribonuclease complex http://purl.obolibrary.org/obo/GO_0000178 goslim_pir GO:0048112 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048112 GO:0000177 biolink:CellularComponent cytoplasmic exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. go.json cytoplasmic exosome (ribonuclease complex)|cytoplasmic exosome multienzyme ribonuclease complex|prokaryotic exosome multienzyme ribonuclease complex http://purl.obolibrary.org/obo/GO_0000177 GO:0048111 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048111 GO:0000176 biolink:CellularComponent nuclear exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. go.json eukaryotic exosome multienzyme ribonuclease complex|nuclear exosome (ribonuclease complex)|nuclear exosome multienzyme ribonuclease complex http://purl.obolibrary.org/obo/GO_0000176 GO:0048110 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048110 GO:0000175 biolink:MolecularActivity 3'-5'-RNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. EC:3.1.13.-|Reactome:R-HSA-430028|Reactome:R-HSA-6791222|Reactome:R-HSA-6791227|Reactome:R-HSA-9682603|Reactome:R-HSA-9694632|Reactome:R-HSA-9822437|Reactome:R-HSA-9836585|Reactome:R-HSA-9836822 go.json 3'-5' exoribonuclease activity|3'-5'-exoribonuclease activity http://purl.obolibrary.org/obo/GO_0000175 GO:1903519 biolink:BiologicalProcess regulation of mammary gland involution Any process that modulates the frequency, rate or extent of mammary gland involution. go.json http://purl.obolibrary.org/obo/GO_1903519 GO:1903518 biolink:BiologicalProcess positive regulation of single strand break repair Any process that activates or increases the frequency, rate or extent of single strand break repair. go.json activation of single strand break repair|up regulation of single strand break repair|up-regulation of single strand break repair|upregulation of single strand break repair http://purl.obolibrary.org/obo/GO_1903518 GO:1903517 biolink:BiologicalProcess negative regulation of single strand break repair Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair. go.json down regulation of single strand break repair|down-regulation of single strand break repair|downregulation of single strand break repair|inhibition of single strand break repair http://purl.obolibrary.org/obo/GO_1903517 GO:0000179 biolink:MolecularActivity rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. Reactome:R-HSA-6790994|Reactome:R-HSA-6793066 go.json 18S rRNA dimethylase activity|S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity|dimethyladenosine transferase activity http://purl.obolibrary.org/obo/GO_0000179 GO:1903516 biolink:BiologicalProcess regulation of single strand break repair Any process that modulates the frequency, rate or extent of single strand break repair. go.json http://purl.obolibrary.org/obo/GO_1903516 GO:1903515 biolink:BiologicalProcess calcium ion transport from cytosol to endoplasmic reticulum The directed movement of calcium ion from cytosol to endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_1903515 GO:0000170 biolink:MolecularActivity sphingosine hydroxylase activity Catalysis of the hydroxylation of sphingolipid long chain bases. Reactome:R-HSA-428260 go.json http://purl.obolibrary.org/obo/GO_0000170 GO:1903514 biolink:BiologicalProcess release of sequestered calcium ion into cytosol by endoplasmic reticulum The directed movement of calcium ion from endoplasmic reticulum to cytosol. go.json calcium ion transport from endoplasmic reticulum to cytosol http://purl.obolibrary.org/obo/GO_1903514 GO:0048119 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048119 GO:1903513 biolink:BiologicalProcess endoplasmic reticulum to cytosol transport The directed movement of substances from endoplasmic reticulum to cytosol. go.json ER to cytosol transport http://purl.obolibrary.org/obo/GO_1903513 GO:0048118 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048118 GO:1903512 biolink:BiologicalProcess phytanic acid metabolic process The chemical reactions and pathways involving phytanic acid. go.json phytanic acid metabolism http://purl.obolibrary.org/obo/GO_1903512 GO:0048117 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048117 GO:0000174 biolink:BiologicalProcess obsolete inactivation of MAPK (mating sensu Saccharomyces) OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces. go.json inactivation of MAPK (mating sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0000174 GO:1903511 biolink:BiologicalProcess orotic acid metabolic process The chemical reactions and pathways involving orotic acid. go.json orotic acid metabolism http://purl.obolibrary.org/obo/GO_1903511 GO:0048116 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048116 GO:1903510 biolink:BiologicalProcess mucopolysaccharide metabolic process The chemical reactions and pathways involving mucopolysaccharide. go.json mucopolysaccharide metabolism http://purl.obolibrary.org/obo/GO_1903510 GO:0000173 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000173 GO:0048115 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048115 GO:0000172 biolink:CellularComponent ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. go.json RNase MRP complex|ribonuclease mitochondrial RNA processing complex http://purl.obolibrary.org/obo/GO_0000172 GO:0048114 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048114 GO:0000171 biolink:MolecularActivity ribonuclease MRP activity Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. Wikipedia:RNase_MRP go.json RNase MRP http://purl.obolibrary.org/obo/GO_0000171 GO:0048113 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048113 GO:0000145 biolink:CellularComponent exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. Wikipedia:Exocyst go.json Sec6/8 complex|exocyst complex http://purl.obolibrary.org/obo/GO_0000145 GO:0048123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048123 GO:0048122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048122 GO:0000144 biolink:CellularComponent cellular bud neck septin ring A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. go.json http://purl.obolibrary.org/obo/GO_0000144 GO:0000143 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000143 GO:0048121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048121 GO:0000142 biolink:CellularComponent cellular bud neck contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae. go.json neck ring http://purl.obolibrary.org/obo/GO_0000142 GO:0048120 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048120 GO:0000149 biolink:MolecularActivity SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. Reactome:R-HSA-210426|Reactome:R-HSA-210430|Reactome:R-HSA-265166|Reactome:R-HSA-372505|Reactome:R-HSA-372529|Reactome:R-HSA-374899|Reactome:R-HSA-374922|Reactome:R-HSA-376357|Reactome:R-HSA-376364|Reactome:R-HSA-376369|Reactome:R-HSA-380574|Reactome:R-HSA-380869|Reactome:R-HSA-380901|Reactome:R-HSA-380905|Reactome:R-HSA-888589|Reactome:R-HSA-9023173|Reactome:R-HSA-917744 go.json SNAP receptor binding http://purl.obolibrary.org/obo/GO_0000149 goslim_chembl GO:0000148 biolink:CellularComponent 1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain. go.json (1->3)-beta-glucan synthase complex|1,3-beta-glucan synthase complex http://purl.obolibrary.org/obo/GO_0000148 GO:1903529 biolink:BiologicalProcess negative regulation of dCDP biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process. go.json down regulation of dCDP anabolism|down regulation of dCDP biosynthesis|down regulation of dCDP biosynthetic process|down regulation of dCDP formation|down regulation of dCDP synthesis|down-regulation of dCDP anabolism|down-regulation of dCDP biosynthesis|down-regulation of dCDP biosynthetic process|down-regulation of dCDP formation|down-regulation of dCDP synthesis|downregulation of dCDP anabolism|downregulation of dCDP biosynthesis|downregulation of dCDP biosynthetic process|downregulation of dCDP formation|downregulation of dCDP synthesis|inhibition of dCDP anabolism|inhibition of dCDP biosynthesis|inhibition of dCDP biosynthetic process|inhibition of dCDP formation|inhibition of dCDP synthesis|negative regulation of dCDP anabolism|negative regulation of dCDP biosynthesis|negative regulation of dCDP formation|negative regulation of dCDP synthesis http://purl.obolibrary.org/obo/GO_1903529 GO:0000147 biolink:BiologicalProcess actin cortical patch assembly Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. go.json http://purl.obolibrary.org/obo/GO_0000147 GO:1903528 biolink:BiologicalProcess regulation of dCDP biosynthetic process Any process that modulates the frequency, rate or extent of dCDP biosynthetic process. go.json regulation of dCDP anabolism|regulation of dCDP biosynthesis|regulation of dCDP formation|regulation of dCDP synthesis http://purl.obolibrary.org/obo/GO_1903528 GO:1903527 biolink:BiologicalProcess positive regulation of membrane tubulation Any process that activates or increases the frequency, rate or extent of membrane tubulation. go.json activation of membrane tubulation|activation of plasma membrane tubulation|positive regulation of plasma membrane tubulation|up regulation of membrane tubulation|up regulation of plasma membrane tubulation|up-regulation of membrane tubulation|up-regulation of plasma membrane tubulation|upregulation of membrane tubulation|upregulation of plasma membrane tubulation http://purl.obolibrary.org/obo/GO_1903527 GO:0000146 biolink:MolecularActivity microfilament motor activity A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. EC:5.6.1.8|Reactome:R-HSA-2316352|Reactome:R-HSA-432237|Reactome:R-HSA-9023171 go.json actin filament motor activity|actin-activated ATPase activity|actin-dependent ATPase activity|actin-filament motor activity|muscle motor activity|myosin ATPase activity http://purl.obolibrary.org/obo/GO_0000146 GO:1903526 biolink:BiologicalProcess negative regulation of membrane tubulation Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation. go.json down regulation of membrane tubulation|down regulation of plasma membrane tubulation|down-regulation of membrane tubulation|down-regulation of plasma membrane tubulation|downregulation of membrane tubulation|downregulation of plasma membrane tubulation|inhibition of membrane tubulation|inhibition of plasma membrane tubulation|negative regulation of plasma membrane tubulation http://purl.obolibrary.org/obo/GO_1903526 GO:1903525 biolink:BiologicalProcess regulation of membrane tubulation Any process that modulates the frequency, rate or extent of membrane tubulation. go.json regulation of plasma membrane tubulation|regulation of vesicle scission http://purl.obolibrary.org/obo/GO_1903525 GO:1903524 biolink:BiologicalProcess positive regulation of blood circulation Any process that activates or increases the frequency, rate or extent of blood circulation. go.json activation of blood circulation|activation of hemolymph circulation|positive regulation of hemolymph circulation|up regulation of blood circulation|up regulation of hemolymph circulation|up-regulation of blood circulation|up-regulation of hemolymph circulation|upregulation of blood circulation|upregulation of hemolymph circulation http://purl.obolibrary.org/obo/GO_1903524 GO:0048129 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048129 GO:1903523 biolink:BiologicalProcess negative regulation of blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. go.json down regulation of blood circulation|down regulation of hemolymph circulation|down-regulation of blood circulation|down-regulation of hemolymph circulation|downregulation of blood circulation|downregulation of hemolymph circulation|inhibition of blood circulation|inhibition of hemolymph circulation|negative regulation of hemolymph circulation http://purl.obolibrary.org/obo/GO_1903523 GO:0048128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048128 GO:0048127 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048127 GO:0000141 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000141 GO:1903522 biolink:BiologicalProcess regulation of blood circulation Any process that modulates the frequency, rate or extent of blood circulation. go.json regulation of hemolymph circulation http://purl.obolibrary.org/obo/GO_1903522 GO:0000140 biolink:MolecularActivity acylglycerone-phosphate reductase activity Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+. EC:1.1.1.101|MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN|RHEA:17341|Reactome:R-HSA-75883 go.json 1-acyldihydroxyacetone-phosphate reductase activity|1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity|acyldihydroxyacetone phosphate reductase activity|palmitoyl dihydroxyacetone phosphate reductase activity|palmitoyl-dihydroxyacetone-phosphate reductase activity|palmitoyldihydroxyacetone-phosphate reductase activity http://purl.obolibrary.org/obo/GO_0000140 GO:1903521 biolink:BiologicalProcess positive regulation of mammary gland involution Any process that activates or increases the frequency, rate or extent of mammary gland involution. go.json activation of mammary gland involution|up regulation of mammary gland involution|up-regulation of mammary gland involution|upregulation of mammary gland involution http://purl.obolibrary.org/obo/GO_1903521 GO:0048126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048126 GO:1903520 biolink:BiologicalProcess negative regulation of mammary gland involution Any process that stops, prevents or reduces the frequency, rate or extent of mammary gland involution. go.json down regulation of mammary gland involution|down-regulation of mammary gland involution|downregulation of mammary gland involution|inhibition of mammary gland involution http://purl.obolibrary.org/obo/GO_1903520 GO:0048125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048125 GO:0048124 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048124 GO:0048134 biolink:BiologicalProcess germ-line cyst formation Formation of a group of interconnected cells derived from a single gonial founder cell. go.json germline cyst formation http://purl.obolibrary.org/obo/GO_0048134 GO:0000156 biolink:MolecularActivity phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. go.json two-component response regulator activity http://purl.obolibrary.org/obo/GO_0000156 GO:0000155 biolink:MolecularActivity phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. EC:2.7.3.- go.json two-component sensor activity|two-component sensor molecule|two-component system sensor activity http://purl.obolibrary.org/obo/GO_0000155 GO:0048133 biolink:BiologicalProcess male germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes. go.json male germ-line stem cell renewal http://purl.obolibrary.org/obo/GO_0048133 GO:0048132 biolink:BiologicalProcess female germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. go.json female germ-line stem cell renewal http://purl.obolibrary.org/obo/GO_0048132 GO:0000154 biolink:BiologicalProcess rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. go.json rRNA editing http://purl.obolibrary.org/obo/GO_0000154 GO:0000153 biolink:CellularComponent cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0000153 GO:0048131 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048131 GO:0048130 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048130 GO:0000159 biolink:CellularComponent protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. go.json PP2A complex|PP2A-pi|PP2a-protector|protein phosphatase 2 complex http://purl.obolibrary.org/obo/GO_0000159 GO:0000158 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000158 GO:1903539 biolink:BiologicalProcess protein localization to postsynaptic membrane A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane. go.json protein localisation in postsynaptic membrane|protein localisation to postsynaptic membrane|protein localization in postsynaptic membrane http://purl.obolibrary.org/obo/GO_1903539 GO:1903538 biolink:BiologicalProcess regulation of meiotic cell cycle process involved in oocyte maturation Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. go.json regulation of meiosis involved in oocyte maturation http://purl.obolibrary.org/obo/GO_1903538 GO:0000157 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000157 GO:1903537 biolink:BiologicalProcess meiotic cell cycle process involved in oocyte maturation Any meiotic cell cycle process that is involved in oocyte maturation. go.json meiosis involved in oocyte maturation http://purl.obolibrary.org/obo/GO_1903537 GO:1903536 biolink:BiologicalProcess positive regulation of lactose biosynthetic process Any process that activates or increases the frequency, rate or extent of lactose biosynthetic process. go.json activation of lactose anabolism|activation of lactose biosynthesis|activation of lactose biosynthetic process|activation of lactose formation|activation of lactose synthesis|positive regulation of lactose anabolism|positive regulation of lactose biosynthesis|positive regulation of lactose formation|positive regulation of lactose synthesis|up regulation of lactose anabolism|up regulation of lactose biosynthesis|up regulation of lactose biosynthetic process|up regulation of lactose formation|up regulation of lactose synthesis|up-regulation of lactose anabolism|up-regulation of lactose biosynthesis|up-regulation of lactose biosynthetic process|up-regulation of lactose formation|up-regulation of lactose synthesis|upregulation of lactose anabolism|upregulation of lactose biosynthesis|upregulation of lactose biosynthetic process|upregulation of lactose formation|upregulation of lactose synthesis http://purl.obolibrary.org/obo/GO_1903536 GO:1903535 biolink:BiologicalProcess negative regulation of lactose biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of lactose biosynthetic process. go.json down regulation of lactose anabolism|down regulation of lactose biosynthesis|down regulation of lactose biosynthetic process|down regulation of lactose formation|down regulation of lactose synthesis|down-regulation of lactose anabolism|down-regulation of lactose biosynthesis|down-regulation of lactose biosynthetic process|down-regulation of lactose formation|down-regulation of lactose synthesis|downregulation of lactose anabolism|downregulation of lactose biosynthesis|downregulation of lactose biosynthetic process|downregulation of lactose formation|downregulation of lactose synthesis|inhibition of lactose anabolism|inhibition of lactose biosynthesis|inhibition of lactose biosynthetic process|inhibition of lactose formation|inhibition of lactose synthesis|negative regulation of lactose anabolism|negative regulation of lactose biosynthesis|negative regulation of lactose formation|negative regulation of lactose synthesis http://purl.obolibrary.org/obo/GO_1903535 GO:0048139 biolink:BiologicalProcess female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad. go.json http://purl.obolibrary.org/obo/GO_0048139 GO:1903534 biolink:BiologicalProcess regulation of lactose biosynthetic process Any process that modulates the frequency, rate or extent of lactose biosynthetic process. go.json regulation of lactose anabolism|regulation of lactose biosynthesis|regulation of lactose formation|regulation of lactose synthesis http://purl.obolibrary.org/obo/GO_1903534 GO:0000152 biolink:CellularComponent nuclear ubiquitin ligase complex A ubiquitin ligase complex found in the nucleus. go.json http://purl.obolibrary.org/obo/GO_0000152 GO:0048138 biolink:BiologicalProcess germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst. go.json http://purl.obolibrary.org/obo/GO_0048138 GO:1903533 biolink:BiologicalProcess regulation of protein targeting Any process that modulates the frequency, rate or extent of protein targeting. go.json regulation of nascent polypeptide association|regulation of protein sorting along secretory pathway http://purl.obolibrary.org/obo/GO_1903533 GO:1903532 biolink:BiologicalProcess positive regulation of secretion by cell Any process that activates or increases the frequency, rate or extent of secretion by cell. go.json activation of cellular secretion|activation of secretion by cell|positive regulation of cellular secretion|up regulation of cellular secretion|up regulation of secretion by cell|up-regulation of cellular secretion|up-regulation of secretion by cell|upregulation of cellular secretion|upregulation of secretion by cell http://purl.obolibrary.org/obo/GO_1903532 GO:0048137 biolink:BiologicalProcess spermatocyte division The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids. go.json spermatocyte cell division http://purl.obolibrary.org/obo/GO_0048137 GO:0000151 biolink:CellularComponent ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. go.json http://purl.obolibrary.org/obo/GO_0000151 goslim_pir GO:0000150 biolink:MolecularActivity DNA strand exchange activity Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. Reactome:R-HSA-912458 go.json RecA-family recombinase activity|recombinase activity|strand exchange activity|strand transferase http://purl.obolibrary.org/obo/GO_0000150 goslim_metagenomics GO:1903531 biolink:BiologicalProcess negative regulation of secretion by cell Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. go.json down regulation of cellular secretion|down regulation of secretion by cell|down-regulation of cellular secretion|down-regulation of secretion by cell|downregulation of cellular secretion|downregulation of secretion by cell|inhibition of cellular secretion|inhibition of secretion by cell|negative regulation of cellular secretion http://purl.obolibrary.org/obo/GO_1903531 GO:0048136 biolink:BiologicalProcess male germ-line cyst formation Formation of a group of interconnected cells derived from a single male gonial founder cell. go.json male germline cyst formation http://purl.obolibrary.org/obo/GO_0048136 GO:1903530 biolink:BiologicalProcess regulation of secretion by cell Any process that modulates the frequency, rate or extent of secretion by cell. go.json regulation of cellular secretion http://purl.obolibrary.org/obo/GO_1903530 GO:0048135 biolink:BiologicalProcess female germ-line cyst formation Formation of a group of interconnected cells derived from a single female gonial founder cell. go.json female germline cyst formation http://purl.obolibrary.org/obo/GO_0048135 GO:1903540 biolink:BiologicalProcess establishment of protein localization to postsynaptic membrane The directed movement of a protein to a specific location in a postsynaptic membrane. go.json establishment of protein localisation in postsynaptic membrane|establishment of protein localisation to postsynaptic membrane|establishment of protein localization in postsynaptic membrane http://purl.obolibrary.org/obo/GO_1903540 GO:0000123 biolink:CellularComponent histone acetyltransferase complex A protein complex that possesses histone acetyltransferase activity. go.json histone acetylase complex http://purl.obolibrary.org/obo/GO_0000123 GO:0048145 biolink:BiologicalProcess regulation of fibroblast proliferation Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. go.json http://purl.obolibrary.org/obo/GO_0048145 GO:0000122 biolink:BiologicalProcess negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. go.json down regulation of global transcription from RNA polymerase II promoter|down regulation of transcription from RNA polymerase II promoter|down-regulation of global transcription from RNA polymerase II promoter|down-regulation of transcription from RNA polymerase II promoter|downregulation of global transcription from RNA polymerase II promoter|downregulation of transcription from RNA polymerase II promoter|inhibition of global transcription from RNA polymerase II promoter|inhibition of transcription from RNA polymerase II promoter|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of global transcription from Pol II promoter|negative regulation of transcription from Pol II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter, global http://purl.obolibrary.org/obo/GO_0000122 GO:0048144 biolink:BiologicalProcess fibroblast proliferation The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. go.json http://purl.obolibrary.org/obo/GO_0048144 GO:0000121 biolink:MolecularActivity glycerol-1-phosphatase activity Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate. EC:3.1.3.21|MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN|RHEA:11476 go.json alpha-glycerol phosphatase activity|alpha-glycerophosphatase activity|glycerol 3-phosphatase activity|glycerol 3-phosphate phosphohydrolase activity|glycerol-1-phosphate phosphohydrolase activity|glycerol-3-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0000121 GO:0048143 biolink:BiologicalProcess astrocyte activation A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0048143 GO:0000120 biolink:CellularComponent RNA polymerase I transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I. go.json RNA polymerase I transcription factor complex http://purl.obolibrary.org/obo/GO_0000120 GO:0048142 biolink:BiologicalProcess germarium-derived cystoblast division The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster. go.json germarium-derived cystoblast cell division http://purl.obolibrary.org/obo/GO_0048142 GO:0048141 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048141 GO:0000127 biolink:CellularComponent transcription factor TFIIIC complex A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. go.json http://purl.obolibrary.org/obo/GO_0000127 GO:0000126 biolink:CellularComponent transcription factor TFIIIB complex A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF. go.json http://purl.obolibrary.org/obo/GO_0000126 GO:0048140 biolink:BiologicalProcess male germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad. go.json http://purl.obolibrary.org/obo/GO_0048140 GO:0000125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000125 GO:1903549 biolink:BiologicalProcess positive regulation of growth hormone activity Any process that activates or increases the frequency, rate or extent of growth hormone activity. go.json activation of GH activity|activation of growth hormone activity|activation of pituitary growth hormone activity|activation of placental growth hormone activity|positive regulation of GH activity|positive regulation of pituitary growth hormone activity|positive regulation of placental growth hormone activity|up regulation of GH activity|up regulation of growth hormone activity|up regulation of pituitary growth hormone activity|up regulation of placental growth hormone activity|up-regulation of GH activity|up-regulation of growth hormone activity|up-regulation of pituitary growth hormone activity|up-regulation of placental growth hormone activity|upregulation of GH activity|upregulation of growth hormone activity|upregulation of pituitary growth hormone activity|upregulation of placental growth hormone activity http://purl.obolibrary.org/obo/GO_1903549 gocheck_do_not_annotate GO:0000124 biolink:CellularComponent SAGA complex A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). go.json PCAF complex|PCAF histone acetylase-associated complex|SPT3-TAF9-GCN5 acetylase complex|SPT3-TAF9-PCAF acetylase complex|STAGA coactivator complex|STAGA complex|Spt-Ada-Gcn5-acetyltransferase complex http://purl.obolibrary.org/obo/GO_0000124 GO:1903548 biolink:BiologicalProcess negative regulation of growth hormone activity Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity. go.json down regulation of GH activity|down regulation of growth hormone activity|down regulation of pituitary growth hormone activity|down regulation of placental growth hormone activity|down-regulation of GH activity|down-regulation of growth hormone activity|down-regulation of pituitary growth hormone activity|down-regulation of placental growth hormone activity|downregulation of GH activity|downregulation of growth hormone activity|downregulation of pituitary growth hormone activity|downregulation of placental growth hormone activity|inhibition of GH activity|inhibition of growth hormone activity|inhibition of pituitary growth hormone activity|inhibition of placental growth hormone activity|negative regulation of GH activity|negative regulation of pituitary growth hormone activity|negative regulation of placental growth hormone activity http://purl.obolibrary.org/obo/GO_1903548 gocheck_do_not_annotate GO:1903547 biolink:BiologicalProcess regulation of growth hormone activity Any process that modulates the frequency, rate or extent of growth hormone activity. go.json regulation of GH activity|regulation of pituitary growth hormone activity|regulation of placental growth hormone activity http://purl.obolibrary.org/obo/GO_1903547 gocheck_do_not_annotate GO:1903546 biolink:BiologicalProcess protein localization to photoreceptor outer segment A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment. go.json protein localisation in photoreceptor outer segment|protein localisation to photoreceptor outer segment|protein localization in photoreceptor outer segment http://purl.obolibrary.org/obo/GO_1903546 GO:1903545 biolink:BiologicalProcess cellular response to butyrate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus. go.json http://purl.obolibrary.org/obo/GO_1903545 GO:1903544 biolink:BiologicalProcess response to butyrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus. go.json http://purl.obolibrary.org/obo/GO_1903544 GO:0048149 biolink:BiologicalProcess behavioral response to ethanol Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus. go.json behavioural response to ethanol http://purl.obolibrary.org/obo/GO_0048149 GO:1903543 biolink:BiologicalProcess positive regulation of exosomal secretion Any process that activates or increases the frequency, rate or extent of exosomal secretion. go.json activation of exosomal protein secretion|activation of exosomal secretion|activation of exosomal secretory pathway|activation of extracellular vesicular exosome secretion|activation of secretion of exosome|positive regulation of exosomal protein secretion|positive regulation of exosomal secretory pathway|positive regulation of extracellular vesicular exosome secretion|positive regulation of secretion of exosome|up regulation of exosomal protein secretion|up regulation of exosomal secretion|up regulation of exosomal secretory pathway|up regulation of extracellular vesicular exosome secretion|up regulation of secretion of exosome|up-regulation of exosomal protein secretion|up-regulation of exosomal secretion|up-regulation of exosomal secretory pathway|up-regulation of extracellular vesicular exosome secretion|up-regulation of secretion of exosome|upregulation of exosomal protein secretion|upregulation of exosomal secretion|upregulation of exosomal secretory pathway|upregulation of extracellular vesicular exosome secretion|upregulation of secretion of exosome http://purl.obolibrary.org/obo/GO_1903543 GO:0048148 biolink:BiologicalProcess behavioral response to cocaine Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. go.json behavioural response to cocaine http://purl.obolibrary.org/obo/GO_0048148 GO:1903542 biolink:BiologicalProcess negative regulation of exosomal secretion Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. go.json down regulation of exosomal protein secretion|down regulation of exosomal secretion|down regulation of exosomal secretory pathway|down regulation of extracellular vesicular exosome secretion|down regulation of secretion of exosome|down-regulation of exosomal protein secretion|down-regulation of exosomal secretion|down-regulation of exosomal secretory pathway|down-regulation of extracellular vesicular exosome secretion|down-regulation of secretion of exosome|downregulation of exosomal protein secretion|downregulation of exosomal secretion|downregulation of exosomal secretory pathway|downregulation of extracellular vesicular exosome secretion|downregulation of secretion of exosome|inhibition of exosomal protein secretion|inhibition of exosomal secretion|inhibition of exosomal secretory pathway|inhibition of extracellular vesicular exosome secretion|inhibition of secretion of exosome|negative regulation of exosomal protein secretion|negative regulation of exosomal secretory pathway|negative regulation of extracellular vesicular exosome secretion|negative regulation of secretion of exosome http://purl.obolibrary.org/obo/GO_1903542 GO:0048147 biolink:BiologicalProcess negative regulation of fibroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. go.json down regulation of fibroblast proliferation|down-regulation of fibroblast proliferation|downregulation of fibroblast proliferation|inhibition of fibroblast proliferation http://purl.obolibrary.org/obo/GO_0048147 GO:0048146 biolink:BiologicalProcess positive regulation of fibroblast proliferation Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. go.json activation of fibroblast proliferation|stimulation of fibroblast proliferation|up regulation of fibroblast proliferation|up-regulation of fibroblast proliferation|upregulation of fibroblast proliferation http://purl.obolibrary.org/obo/GO_0048146 GO:1903541 biolink:BiologicalProcess regulation of exosomal secretion Any process that modulates the frequency, rate or extent of exosomal secretion. go.json regulation of exosomal protein secretion|regulation of exosomal secretory pathway|regulation of extracellular vesicular exosome secretion|regulation of secretion of exosome http://purl.obolibrary.org/obo/GO_1903541 GO:1903551 biolink:BiologicalProcess regulation of extracellular exosome assembly Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. go.json regulation of extracellular vesicular exosome assembly http://purl.obolibrary.org/obo/GO_1903551 GO:0000129 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000129 GO:0000128 biolink:BiologicalProcess flocculation The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs. Wikipedia:Flocculation go.json cell-cell adhesion involved in flocculation|cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction|co-flocculation|coflocculation|coflocculation via lectin-mannose interaction|coflocculation via protein-carbohydrate interaction|flocculation via cell wall protein-carbohydrate interaction|flocculation via extracellular polymer http://purl.obolibrary.org/obo/GO_0000128 goslim_pir GO:0000134 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000134 GO:0048156 biolink:MolecularActivity tau protein binding Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. go.json http://purl.obolibrary.org/obo/GO_0048156 GO:0048155 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048155 GO:0000133 biolink:CellularComponent polarisome Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p. go.json http://purl.obolibrary.org/obo/GO_0000133 goslim_pir GO:0000132 biolink:BiologicalProcess establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. go.json establishment of spindle orientation during mitosis|establishment of spindle orientation involved in mitotic cell cycle|mitotic spindle orientation|orienting of mitotic spindle http://purl.obolibrary.org/obo/GO_0000132 GO:0048154 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048154 GO:0048153 biolink:BiologicalProcess obsolete S100 alpha biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. go.json S100 alpha anabolism|S100 alpha biosynthesis|S100 alpha formation|S100 alpha synthesis True http://purl.obolibrary.org/obo/GO_0048153 GO:0000131 biolink:CellularComponent incipient cellular bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence. go.json http://purl.obolibrary.org/obo/GO_0000131 GO:0048152 biolink:BiologicalProcess obsolete S100 beta biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. go.json S100 beta anabolism|S100 beta biosynthesis|S100 beta formation|S100 beta synthesis True http://purl.obolibrary.org/obo/GO_0048152 GO:0000138 biolink:CellularComponent Golgi trans cisterna The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. go.json late Golgi http://purl.obolibrary.org/obo/GO_0000138 GO:0000137 biolink:CellularComponent Golgi cis cisterna The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. go.json Golgi apparatus cis cisterna http://purl.obolibrary.org/obo/GO_0000137 GO:0048151 biolink:BiologicalProcess obsolete hyperphosphorylation OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both. go.json hyperphosphorylation True http://purl.obolibrary.org/obo/GO_0048151 GO:0048150 biolink:BiologicalProcess behavioral response to ether Any process that results in a change in the behavior of an organism as a result of an ether stimulus. go.json behavioural response to ether http://purl.obolibrary.org/obo/GO_0048150 GO:0000136 biolink:CellularComponent mannan polymerase complex A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. go.json alpha-1,6-mannosyltransferase complex http://purl.obolibrary.org/obo/GO_0000136 GO:0000135 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000135 GO:1903559 biolink:BiologicalProcess 3-cyano-L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine. go.json 3-cyano-L-alanine breakdown|3-cyano-L-alanine catabolism|3-cyano-L-alanine degradation http://purl.obolibrary.org/obo/GO_1903559 GO:1903558 biolink:BiologicalProcess 3-cyano-L-alanine metabolic process The chemical reactions and pathways involving 3-cyano-L-alanine. go.json 3-cyano-L-alanine metabolism http://purl.obolibrary.org/obo/GO_1903558 GO:1903557 biolink:BiologicalProcess positive regulation of tumor necrosis factor superfamily cytokine production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. go.json activation of TNF superfamily production|activation of TNFSF cytokine production|activation of tumor necrosis factor superfamily cytokine production|positive regulation of TNF superfamily production|positive regulation of TNFSF cytokine production|up regulation of TNF superfamily production|up regulation of TNFSF cytokine production|up regulation of tumor necrosis factor superfamily cytokine production|up-regulation of TNF superfamily production|up-regulation of TNFSF cytokine production|up-regulation of tumor necrosis factor superfamily cytokine production|upregulation of TNF superfamily production|upregulation of TNFSF cytokine production|upregulation of tumor necrosis factor superfamily cytokine production http://purl.obolibrary.org/obo/GO_1903557 GO:1903556 biolink:BiologicalProcess negative regulation of tumor necrosis factor superfamily cytokine production Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. go.json down regulation of TNF superfamily production|down regulation of TNFSF cytokine production|down regulation of tumor necrosis factor superfamily cytokine production|down-regulation of TNF superfamily production|down-regulation of TNFSF cytokine production|down-regulation of tumor necrosis factor superfamily cytokine production|downregulation of TNF superfamily production|downregulation of TNFSF cytokine production|downregulation of tumor necrosis factor superfamily cytokine production|inhibition of TNF superfamily production|inhibition of TNFSF cytokine production|inhibition of tumor necrosis factor superfamily cytokine production|negative regulation of TNF superfamily production|negative regulation of TNFSF cytokine production http://purl.obolibrary.org/obo/GO_1903556 GO:1903555 biolink:BiologicalProcess regulation of tumor necrosis factor superfamily cytokine production Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. go.json regulation of TNF superfamily production|regulation of TNFSF cytokine production http://purl.obolibrary.org/obo/GO_1903555 GO:0000130 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000130 GO:1903554 biolink:BiologicalProcess G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium A G protein-coupled receptor signaling pathway that is involved in the defense response to Gram-negative bacterium. go.json G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity|G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria|G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium|G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria|G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium|G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity|G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria|G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium|G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria|G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium|G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria|G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium|G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria|G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium|G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria|G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium|G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria|G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria|G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium|G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity|G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria|G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium|G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium|G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity|G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria|G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium|G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria|G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium|GPCR signaling pathway involved in Gram-negative antibacterial peptide activity|GPCR signaling pathway involved in defence response to Gram-negative bacteria|GPCR signaling pathway involved in defence response to Gram-negative bacterium|GPCR signaling pathway involved in defense response to Gram-negative bacteria|GPCR signaling pathway involved in defense response to Gram-negative bacterium|GPCR signalling pathway involved in Gram-negative antibacterial peptide activity|GPCR signalling pathway involved in defence response to Gram-negative bacteria|GPCR signalling pathway involved in defence response to Gram-negative bacterium|GPCR signalling pathway involved in defense response to Gram-negative bacteria|GPCR signalling pathway involved in defense response to Gram-negative bacterium http://purl.obolibrary.org/obo/GO_1903554 GO:0048159 biolink:BiologicalProcess primary oocyte stage The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells. go.json mammalian oogenesis stage 2 http://purl.obolibrary.org/obo/GO_0048159 GO:1903553 biolink:BiologicalProcess positive regulation of extracellular exosome assembly Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. go.json activation of extracellular vesicular exosome assembly|positive regulation of extracellular vesicular exosome assembly|up regulation of extracellular vesicular exosome assembly|up-regulation of extracellular vesicular exosome assembly|upregulation of extracellular vesicular exosome assembly http://purl.obolibrary.org/obo/GO_1903553 GO:0048158 biolink:BiologicalProcess oogonium stage The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary. go.json mammalian oogenesis stage 1 http://purl.obolibrary.org/obo/GO_0048158 GO:1903552 biolink:BiologicalProcess negative regulation of extracellular exosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. go.json down regulation of extracellular vesicular exosome assembly|down-regulation of extracellular vesicular exosome assembly|downregulation of extracellular vesicular exosome assembly|inhibition of extracellular vesicular exosome assembly|negative regulation of extracellular vesicular exosome assembly http://purl.obolibrary.org/obo/GO_1903552 GO:0048157 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048157 GO:1903562 biolink:BiologicalProcess microtubule bundle formation involved in mitotic spindle midzone assembly Any microtubule bundle formation that is involved in spindle midzone assembly involved in mitosis. go.json microtubule bundle formation involved in mitotic spindle midzone formation|microtubule bundle formation involved in spindle midzone assembly involved in mitosis|microtubule bundling involved in mitotic spindle midzone assembly|microtubule bundling involved in mitotic spindle midzone formation|microtubule bundling involved in spindle midzone assembly involved in mitosis|microtubule bundling involved in spindle midzone biogenesis involved in mitosis|microtubule bundling involved in spindle midzone formation involved in mitosis http://purl.obolibrary.org/obo/GO_1903562 GO:1903561 biolink:CellularComponent extracellular vesicle Any vesicle that is part of the extracellular region. go.json microparticle http://purl.obolibrary.org/obo/GO_1903561 GO:1903560 biolink:BiologicalProcess 3-cyano-L-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine. go.json 3-cyano-L-alanine anabolism|3-cyano-L-alanine biosynthesis|3-cyano-L-alanine formation|3-cyano-L-alanine synthesis http://purl.obolibrary.org/obo/GO_1903560 GO:0000139 biolink:CellularComponent Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. go.json Golgi apparatus membrane http://purl.obolibrary.org/obo/GO_0000139 GO:0000101 biolink:BiologicalProcess sulfur amino acid transport The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json sulphur amino acid transport http://purl.obolibrary.org/obo/GO_0000101 GO:0048167 biolink:BiologicalProcess regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. go.json http://purl.obolibrary.org/obo/GO_0048167 GO:0048166 biolink:BiologicalProcess mature follicle stage The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division. go.json mammalian oogenesis stage 9 http://purl.obolibrary.org/obo/GO_0048166 GO:0000100 biolink:MolecularActivity S-methylmethionine transmembrane transporter activity Enables the transfer of S-methylmethionine from one side of a membrane to the other. go.json S-methylmethionine permease activity|S-methylmethionine transporter activity http://purl.obolibrary.org/obo/GO_0000100 GO:0048165 biolink:BiologicalProcess fused antrum stage The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space. go.json mammalian oogenesis stage 8 http://purl.obolibrary.org/obo/GO_0048165 GO:0048164 biolink:BiologicalProcess distinct antral spaces stage The stage in oogenesis when the antral spaces become distinct and the first polar body forms. go.json mammalian oogenesis stage 7 http://purl.obolibrary.org/obo/GO_0048164 GO:0000105 biolink:BiologicalProcess histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. MetaCyc:HISTSYN-PWY go.json histidine anabolism|histidine biosynthesis|histidine formation|histidine synthesis http://purl.obolibrary.org/obo/GO_0000105 GO:0048163 biolink:BiologicalProcess scattered antral spaces stage The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration. go.json mammalian oogenesis stage 6 http://purl.obolibrary.org/obo/GO_0048163 GO:0000104 biolink:MolecularActivity succinate dehydrogenase activity Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. KEGG:R00412|RHEA:16357 go.json fumarate dehydrogenase activity|fumarate reductase activity|fumaric hydrogenase activity|succinate oxidoreductase activity|succinic acid dehydrogenase activity|succinic dehydrogenase activity|succinodehydrogenase activity|succinyl dehydrogenase activity http://purl.obolibrary.org/obo/GO_0000104 GO:0048162 biolink:BiologicalProcess multi-layer follicle stage The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle. go.json mammalian oogenesis stage 5 http://purl.obolibrary.org/obo/GO_0048162 GO:0000103 biolink:BiologicalProcess sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. go.json sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|sulphate assimilation|sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0000103 GO:0048161 biolink:BiologicalProcess double layer follicle stage The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus. go.json mammalian oogenesis stage 4 http://purl.obolibrary.org/obo/GO_0048161 GO:0048160 biolink:BiologicalProcess primary follicle stage The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large. go.json mammalian oogenesis stage 3 http://purl.obolibrary.org/obo/GO_0048160 GO:0000102 biolink:MolecularActivity L-methionine secondary active transmembrane transporter activity Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json L-methionine porter activity http://purl.obolibrary.org/obo/GO_0000102 GO:1903569 biolink:BiologicalProcess positive regulation of protein localization to ciliary membrane Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. go.json activation of protein localisation in ciliary membrane|activation of protein localisation to ciliary membrane|activation of protein localization in ciliary membrane|activation of protein localization to ciliary membrane|positive regulation of protein localisation in ciliary membrane|positive regulation of protein localisation to ciliary membrane|positive regulation of protein localization in ciliary membrane|up regulation of protein localisation in ciliary membrane|up regulation of protein localisation to ciliary membrane|up regulation of protein localization in ciliary membrane|up regulation of protein localization to ciliary membrane|up-regulation of protein localisation in ciliary membrane|up-regulation of protein localisation to ciliary membrane|up-regulation of protein localization in ciliary membrane|up-regulation of protein localization to ciliary membrane|upregulation of protein localisation in ciliary membrane|upregulation of protein localisation to ciliary membrane|upregulation of protein localization in ciliary membrane|upregulation of protein localization to ciliary membrane http://purl.obolibrary.org/obo/GO_1903569 GO:1903568 biolink:BiologicalProcess negative regulation of protein localization to ciliary membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. go.json down regulation of protein localisation in ciliary membrane|down regulation of protein localisation to ciliary membrane|down regulation of protein localization in ciliary membrane|down regulation of protein localization to ciliary membrane|down-regulation of protein localisation in ciliary membrane|down-regulation of protein localisation to ciliary membrane|down-regulation of protein localization in ciliary membrane|down-regulation of protein localization to ciliary membrane|downregulation of protein localisation in ciliary membrane|downregulation of protein localisation to ciliary membrane|downregulation of protein localization in ciliary membrane|downregulation of protein localization to ciliary membrane|inhibition of protein localisation in ciliary membrane|inhibition of protein localisation to ciliary membrane|inhibition of protein localization in ciliary membrane|inhibition of protein localization to ciliary membrane|negative regulation of protein localisation in ciliary membrane|negative regulation of protein localisation to ciliary membrane|negative regulation of protein localization in ciliary membrane http://purl.obolibrary.org/obo/GO_1903568 GO:0014748 biolink:BiologicalProcess negative regulation of tonic skeletal muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014748 GO:1903567 biolink:BiologicalProcess regulation of protein localization to ciliary membrane Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. go.json regulation of protein localisation in ciliary membrane|regulation of protein localisation to ciliary membrane|regulation of protein localization in ciliary membrane http://purl.obolibrary.org/obo/GO_1903567 GO:0014747 biolink:BiologicalProcess positive regulation of tonic skeletal muscle contraction Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014747 GO:1903566 biolink:BiologicalProcess positive regulation of protein localization to cilium Any process that activates or increases the frequency, rate or extent of protein localization to cilium. go.json activation of protein localization to cilium|up regulation of protein localization to cilium|up-regulation of protein localization to cilium|upregulation of protein localization to cilium http://purl.obolibrary.org/obo/GO_1903566 GO:1903565 biolink:BiologicalProcess negative regulation of protein localization to cilium Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. go.json down regulation of protein localization to cilium|down-regulation of protein localization to cilium|downregulation of protein localization to cilium|inhibition of protein localization to cilium http://purl.obolibrary.org/obo/GO_1903565 GO:0048169 biolink:BiologicalProcess regulation of long-term neuronal synaptic plasticity A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. go.json http://purl.obolibrary.org/obo/GO_0048169 GO:1903564 biolink:BiologicalProcess regulation of protein localization to cilium Any process that modulates the frequency, rate or extent of protein localization to cilium. go.json http://purl.obolibrary.org/obo/GO_1903564 GO:1903563 biolink:BiologicalProcess microtubule bundle formation involved in horsetail-astral microtubule organization Any microtubule bundle formation that is involved in horsetail-astral microtubule organization. go.json microtubule bundle formation involved in horsetail-astral microtubule array organization|microtubule bundle formation involved in horsetail-astral microtubule organisation|microtubule bundling involved in horsetail-astral microtubule array organization|microtubule bundling involved in horsetail-astral microtubule organisation|microtubule bundling involved in horsetail-astral microtubule organization http://purl.obolibrary.org/obo/GO_1903563 GO:0048168 biolink:BiologicalProcess regulation of neuronal synaptic plasticity A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. go.json http://purl.obolibrary.org/obo/GO_0048168 GO:1903573 biolink:BiologicalProcess negative regulation of response to endoplasmic reticulum stress Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. go.json down regulation of ER stress response|down regulation of cellular response to endoplasmic reticulum stress|down regulation of response to ER stress|down regulation of response to endoplasmic reticulum stress|down-regulation of ER stress response|down-regulation of cellular response to endoplasmic reticulum stress|down-regulation of response to ER stress|down-regulation of response to endoplasmic reticulum stress|downregulation of ER stress response|downregulation of cellular response to endoplasmic reticulum stress|downregulation of response to ER stress|downregulation of response to endoplasmic reticulum stress|inhibition of ER stress response|inhibition of cellular response to endoplasmic reticulum stress|inhibition of response to ER stress|inhibition of response to endoplasmic reticulum stress|negative regulation of ER stress response|negative regulation of cellular response to endoplasmic reticulum stress|negative regulation of response to ER stress http://purl.obolibrary.org/obo/GO_1903573 GO:0014742 biolink:BiologicalProcess positive regulation of muscle hypertrophy Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. go.json http://purl.obolibrary.org/obo/GO_0014742 GO:1903572 biolink:BiologicalProcess positive regulation of protein kinase D signaling Any process that activates or increases the frequency, rate or extent of protein kinase D signaling. go.json activation of PKD signal transduction|activation of PKD signaling cascade|activation of protein kinase D signal transduction|activation of protein kinase D signaling|activation of protein kinase D signaling cascade|activation of protein kinase D signalling cascade|positive regulation of PKD signal transduction|positive regulation of PKD signaling cascade|positive regulation of protein kinase D signal transduction|positive regulation of protein kinase D signaling cascade|positive regulation of protein kinase D signalling cascade|up regulation of PKD signal transduction|up regulation of PKD signaling cascade|up regulation of protein kinase D signal transduction|up regulation of protein kinase D signaling|up regulation of protein kinase D signaling cascade|up regulation of protein kinase D signalling cascade|up-regulation of PKD signal transduction|up-regulation of PKD signaling cascade|up-regulation of protein kinase D signal transduction|up-regulation of protein kinase D signaling|up-regulation of protein kinase D signaling cascade|up-regulation of protein kinase D signalling cascade|upregulation of PKD signal transduction|upregulation of PKD signaling cascade|upregulation of protein kinase D signal transduction|upregulation of protein kinase D signaling|upregulation of protein kinase D signaling cascade|upregulation of protein kinase D signalling cascade http://purl.obolibrary.org/obo/GO_1903572 GO:0014741 biolink:BiologicalProcess negative regulation of muscle hypertrophy Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. go.json http://purl.obolibrary.org/obo/GO_0014741 GO:1903571 biolink:BiologicalProcess negative regulation of protein kinase D signaling Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase D signaling. go.json down regulation of PKD signal transduction|down regulation of PKD signaling cascade|down regulation of protein kinase D signal transduction|down regulation of protein kinase D signaling|down regulation of protein kinase D signaling cascade|down regulation of protein kinase D signalling cascade|down-regulation of PKD signal transduction|down-regulation of PKD signaling cascade|down-regulation of protein kinase D signal transduction|down-regulation of protein kinase D signaling|down-regulation of protein kinase D signaling cascade|down-regulation of protein kinase D signalling cascade|downregulation of PKD signal transduction|downregulation of PKD signaling cascade|downregulation of protein kinase D signal transduction|downregulation of protein kinase D signaling|downregulation of protein kinase D signaling cascade|downregulation of protein kinase D signalling cascade|inhibition of PKD signal transduction|inhibition of PKD signaling cascade|inhibition of protein kinase D signal transduction|inhibition of protein kinase D signaling|inhibition of protein kinase D signaling cascade|inhibition of protein kinase D signalling cascade|negative regulation of PKD signal transduction|negative regulation of PKD signaling cascade|negative regulation of protein kinase D signal transduction|negative regulation of protein kinase D signaling cascade|negative regulation of protein kinase D signalling cascade http://purl.obolibrary.org/obo/GO_1903571 GO:0014740 biolink:BiologicalProcess negative regulation of muscle hyperplasia Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia. go.json http://purl.obolibrary.org/obo/GO_0014740 GO:1903570 biolink:BiologicalProcess regulation of protein kinase D signaling Any process that modulates the frequency, rate or extent of protein kinase D signaling. go.json regulation of PKD signal transduction|regulation of PKD signaling cascade|regulation of protein kinase D signal transduction|regulation of protein kinase D signaling cascade|regulation of protein kinase D signalling cascade http://purl.obolibrary.org/obo/GO_1903570 GO:0014746 biolink:BiologicalProcess regulation of tonic skeletal muscle contraction Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014746 GO:0014745 biolink:BiologicalProcess negative regulation of muscle adaptation Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. go.json negative regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014745 GO:0014744 biolink:BiologicalProcess positive regulation of muscle adaptation Any process that activates or increases the frequency, rate or extent of muscle adaptation. go.json positive regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014744 GO:0014743 biolink:BiologicalProcess regulation of muscle hypertrophy Any process that modulates the frequency, rate or extent of muscle hypertrophy. go.json http://purl.obolibrary.org/obo/GO_0014743 GO:0048170 biolink:BiologicalProcess positive regulation of long-term neuronal synaptic plasticity A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. go.json activation of long-term neuronal synaptic plasticity|stimulation of long-term neuronal synaptic plasticity|up regulation of long-term neuronal synaptic plasticity|up-regulation of long-term neuronal synaptic plasticity|upregulation of long-term neuronal synaptic plasticity http://purl.obolibrary.org/obo/GO_0048170 GO:0000109 biolink:CellularComponent nucleotide-excision repair complex Any complex formed of proteins that act in nucleotide-excision repair. go.json UvrB-UvrC complex|UvrBC complex http://purl.obolibrary.org/obo/GO_0000109 goslim_pir GO:0000108 biolink:CellularComponent obsolete repairosome OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage. go.json repairosome True http://purl.obolibrary.org/obo/GO_0000108 GO:0000107 biolink:MolecularActivity imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. MetaCyc:GLUTAMIDOTRANS-RXN|RHEA:24793 go.json glutamine amidotransferase:cyclase activity|imidazole glycerol phosphate synthase activity|imidazole-glycerol-phosphate synthase activity|imidazoleglycerol phosphate synthase activity http://purl.obolibrary.org/obo/GO_0000107 GO:0000106 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000106 GO:0048178 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048178 GO:0000112 biolink:CellularComponent nucleotide-excision repair factor 3 complex One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p). go.json NEF3 complex http://purl.obolibrary.org/obo/GO_0000112 GO:0000111 biolink:CellularComponent nucleotide-excision repair factor 2 complex One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p. go.json NEF2 complex http://purl.obolibrary.org/obo/GO_0000111 GO:0048177 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048177 GO:0000110 biolink:CellularComponent nucleotide-excision repair factor 1 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively. go.json NEF1 complex|XPA-ERCC1-ERCC4 complex http://purl.obolibrary.org/obo/GO_0000110 GO:0048176 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048176 GO:0048175 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048175 GO:0000116 biolink:BiologicalProcess obsolete regulation of transcription involved in G2-phase of mitotic cell cycle OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle. go.json G2-specific transcription in mitotic cell cycle|regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle|regulation of transcription involved in G2-phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0000116 GO:0048174 biolink:BiologicalProcess negative regulation of short-term neuronal synaptic plasticity A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. go.json down regulation of short-term neuronal synaptic plasticity|down-regulation of short-term neuronal synaptic plasticity|downregulation of short-term neuronal synaptic plasticity|inhibition of short-term neuronal synaptic plasticity http://purl.obolibrary.org/obo/GO_0048174 GO:0000115 biolink:BiologicalProcess obsolete regulation of transcription involved in S phase of mitotic cell cycle OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle. go.json S-phase-specific transcription in mitotic cell cycle|S-specific transcription in mitotic cell cycle|regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle|regulation of transcription involved in S phase of mitotic cell cycle|regulation of transcription involved in S-phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0000115 GO:0048173 biolink:BiologicalProcess positive regulation of short-term neuronal synaptic plasticity A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. go.json activation of short-term neuronal synaptic plasticity|stimulation of short-term neuronal synaptic plasticity|up regulation of short-term neuronal synaptic plasticity|up-regulation of short-term neuronal synaptic plasticity|upregulation of short-term neuronal synaptic plasticity http://purl.obolibrary.org/obo/GO_0048173 GO:0048172 biolink:BiologicalProcess regulation of short-term neuronal synaptic plasticity A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. go.json http://purl.obolibrary.org/obo/GO_0048172 GO:0000114 biolink:BiologicalProcess obsolete regulation of transcription involved in G1 phase of mitotic cell cycle OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle. go.json G1-specific transcription in mitotic cell cycle|regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0000114 GO:0048171 biolink:BiologicalProcess negative regulation of long-term neuronal synaptic plasticity A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. go.json down regulation of long-term neuronal synaptic plasticity|down-regulation of long-term neuronal synaptic plasticity|downregulation of long-term neuronal synaptic plasticity|inhibition of long-term neuronal synaptic plasticity http://purl.obolibrary.org/obo/GO_0048171 GO:0000113 biolink:CellularComponent nucleotide-excision repair factor 4 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p. go.json NEF4 complex http://purl.obolibrary.org/obo/GO_0000113 GO:1903579 biolink:BiologicalProcess negative regulation of ATP metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. go.json down regulation of ATP metabolic process|down regulation of ATP metabolism|down-regulation of ATP metabolic process|down-regulation of ATP metabolism|downregulation of ATP metabolic process|downregulation of ATP metabolism|inhibition of ATP metabolic process|inhibition of ATP metabolism|negative regulation of ATP metabolism http://purl.obolibrary.org/obo/GO_1903579 GO:1903578 biolink:BiologicalProcess regulation of ATP metabolic process Any process that modulates the frequency, rate or extent of ATP metabolic process. go.json regulation of ATP metabolism http://purl.obolibrary.org/obo/GO_1903578 GO:1903577 biolink:BiologicalProcess cellular response to L-arginine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus. go.json http://purl.obolibrary.org/obo/GO_1903577 GO:1903576 biolink:BiologicalProcess response to L-arginine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus. go.json http://purl.obolibrary.org/obo/GO_1903576 GO:1903575 biolink:BiologicalProcess cornified envelope assembly The aggregation, arrangement and bonding together of a set of components to form a cornified envelope. go.json cornified envelope formation http://purl.obolibrary.org/obo/GO_1903575 GO:1903574 biolink:BiologicalProcess negative regulation of cellular response to amino acid starvation Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation. go.json down regulation of cellular response to amino acid starvation|down-regulation of cellular response to amino acid starvation|downregulation of cellular response to amino acid starvation|inhibition of cellular response to amino acid starvation http://purl.obolibrary.org/obo/GO_1903574 GO:0048179 biolink:CellularComponent activin receptor complex A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. go.json http://purl.obolibrary.org/obo/GO_0048179 GO:1903584 biolink:BiologicalProcess regulation of histone deubiquitination Any process that modulates the frequency, rate or extent of histone deubiquitination. go.json regulation of histone deubiquitinylation|regulation of histone deubiquitylation http://purl.obolibrary.org/obo/GO_1903584 GO:1903583 biolink:BiologicalProcess positive regulation of basophil degranulation Any process that activates or increases the frequency, rate or extent of basophil degranulation. go.json activation of basophil degranulation|up regulation of basophil degranulation|up-regulation of basophil degranulation|upregulation of basophil degranulation http://purl.obolibrary.org/obo/GO_1903583 GO:1903582 biolink:BiologicalProcess negative regulation of basophil degranulation Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation. go.json down regulation of basophil degranulation|down-regulation of basophil degranulation|downregulation of basophil degranulation|inhibition of basophil degranulation http://purl.obolibrary.org/obo/GO_1903582 GO:1903581 biolink:BiologicalProcess regulation of basophil degranulation Any process that modulates the frequency, rate or extent of basophil degranulation. go.json http://purl.obolibrary.org/obo/GO_1903581 GO:1903580 biolink:BiologicalProcess positive regulation of ATP metabolic process Any process that activates or increases the frequency, rate or extent of ATP metabolic process. go.json activation of ATP metabolic process|activation of ATP metabolism|positive regulation of ATP metabolism|up regulation of ATP metabolic process|up regulation of ATP metabolism|up-regulation of ATP metabolic process|up-regulation of ATP metabolism|upregulation of ATP metabolic process|upregulation of ATP metabolism http://purl.obolibrary.org/obo/GO_1903580 GO:0048181 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048181 GO:0048180 biolink:CellularComponent activin complex A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit. go.json http://purl.obolibrary.org/obo/GO_0048180 goslim_pir GO:0000119 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000119 GO:0000118 biolink:CellularComponent histone deacetylase complex A protein complex that possesses histone deacetylase activity. go.json HDAC complex http://purl.obolibrary.org/obo/GO_0000118 GO:0000117 biolink:BiologicalProcess obsolete regulation of transcription involved in G2/M transition of mitotic cell cycle OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle. go.json G2/M-specific transcription in mitotic cell cycle|regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0000117 GO:0000189 biolink:BiologicalProcess obsolete MAPK import into nucleus OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation. go.json nuclear translocation of MAPK True http://purl.obolibrary.org/obo/GO_0000189 GO:0000188 biolink:BiologicalProcess obsolete inactivation of MAPK activity OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase. go.json inactivation of MAPK during sporulation|termination of MAPK activity True http://purl.obolibrary.org/obo/GO_0000188 GO:0000187 biolink:BiologicalProcess obsolete activation of MAPK activity OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase (MAPK). go.json MAPK activation|activation of MAP kinase|activation of MAPK activity during sporulation True http://purl.obolibrary.org/obo/GO_0000187 GO:0000186 biolink:BiologicalProcess obsolete activation of MAPKK activity OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). go.json activation of MAP kinase kinase activity|activation of MAP/ERK kinase kinase|activation of MAP2K activity|activation of MAPKK activity during sporulation|positive regulation of MAPKK activity True http://purl.obolibrary.org/obo/GO_0000186 GO:0000181 biolink:CellularComponent obsolete cytosolic small ribosomal subunit OBSOLETE. (Was not defined before being made obsolete). go.json cytosolic small ribosomal subunit True http://purl.obolibrary.org/obo/GO_0000181 GO:0000180 biolink:CellularComponent obsolete cytosolic large ribosomal subunit OBSOLETE. (Was not defined before being made obsolete). go.json cytosolic large ribosomal subunit True http://purl.obolibrary.org/obo/GO_0000180 GO:0000185 biolink:BiologicalProcess obsolete activation of MAPKKK activity OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). go.json activation of MAP kinase kinase kinase|activation of MAP3K activity|activation of MAPKKK activity during sporulation|positive regulation of MAP kinase kinase kinase activity|positive regulation of MAPKKK activity True http://purl.obolibrary.org/obo/GO_0000185 GO:0000184 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. Wikipedia:Nonsense-mediated_decay|Wikipedia:Nonsense-mediated_mRNA_decay go.json mRNA breakdown, nonsense-mediated decay|mRNA catabolic process, nonsense-mediated|mRNA catabolism, nonsense-mediated|mRNA degradation, nonsense-mediated decay|nonsense-mediated mRNA decay|nuclear mRNA catabolic process, nonsense-mediated decay http://purl.obolibrary.org/obo/GO_0000184 GO:0000183 biolink:BiologicalProcess rDNA heterochromatin formation The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3. go.json chromatin silencing at rDNA|chromatin silencing at ribosomal DNA|heterochromatic silencing at rDNA|rDNA chromatin silencing|rDNA heterochromatin assembly http://purl.obolibrary.org/obo/GO_0000183 GO:0000182 biolink:MolecularActivity rDNA binding Binding to a DNA sequence encoding a ribosomal RNA. go.json ribosomal DNA binding http://purl.obolibrary.org/obo/GO_0000182 GO:0000199 biolink:BiologicalProcess obsolete activation of MAPK activity involved in cell wall organization or biogenesis OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. go.json activation of MAPK activity involved in cell wall biogenesis|activation of MAPK activity involved in cell wall integrity|cell wall biogenesis, activation of MAPK activity True http://purl.obolibrary.org/obo/GO_0000199 GO:0000198 biolink:BiologicalProcess obsolete activation of MAPKK activity involved in cell wall organization or biogenesis OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis. go.json activation of MAP kinase kinase activity during cell wall biogenesis|activation of MAPKK activity involved in cell wall biogenesis|activation of MAPKK activity involved in cell wall integrity|cell wall biogenesis, activation of MAP kinase kinase activity|cell wall biogenesis, activation of MAPKK activity True http://purl.obolibrary.org/obo/GO_0000198 GO:0000197 biolink:BiologicalProcess obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis. go.json activation of MAP kinase kinase kinase activity during cell wall biogenesis|activation of MAPKKK activity involved in cell wall biogenesis|activation of MAPKKK activity involved in cell wall integrity|cell wall biogenesis, activation of MAP kinase kinase kinase activity|cell wall biogenesis, activation of MAPKKK activity True http://purl.obolibrary.org/obo/GO_0000197 GO:0000192 biolink:BiologicalProcess obsolete activation of MAPKK (pseudohyphal growth) OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth. go.json activation of MAPKK (pseudohyphal growth) True http://purl.obolibrary.org/obo/GO_0000192 GO:0000191 biolink:BiologicalProcess obsolete activation of MAPKKK (pseudohyphal growth) OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth. go.json activation of MAPKKK (pseudohyphal growth) True http://purl.obolibrary.org/obo/GO_0000191 GO:0000190 biolink:BiologicalProcess obsolete MAPKKK cascade (pseudohyphal growth) OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth. go.json MAPKKK cascade (pseudohyphal growth) True http://purl.obolibrary.org/obo/GO_0000190 GO:0000196 biolink:BiologicalProcess cell wall integrity MAPK cascade A MAPK cascade that contributes to cell wall organization or biogenesis. go.json MAPK cascade involved in cell wall biogenesis|MAPK cascade involved in cell wall organization or biogenesis|MAPKKK cascade involved in cell wall biogenesis|Mpk1 cascade|PMK1-MAPK signal transduction pathway|Pmk1 MAPK cell integrity signaling|Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|Slt2 cascade|cell integrity MAPK pathway|cell wall biogenesis, MAPKKK cascade http://purl.obolibrary.org/obo/GO_0000196 GO:0000195 biolink:BiologicalProcess obsolete nuclear translocation of MAPK (pseudohyphal growth) OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth. go.json nuclear translocation of MAPK (pseudohyphal growth) True http://purl.obolibrary.org/obo/GO_0000195 GO:0000194 biolink:BiologicalProcess obsolete inactivation of MAPK (pseudohyphal growth) OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth. go.json inactivation of MAPK (pseudohyphal growth) True http://purl.obolibrary.org/obo/GO_0000194 GO:0000193 biolink:BiologicalProcess obsolete activation of MAPK (pseudohyphal growth) OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth. go.json activation of MAPK (pseudohyphal growth) True http://purl.obolibrary.org/obo/GO_0000193 GO:0097299 biolink:MolecularActivity obsolete cysteine-type endopeptidase activity involved in plant-type hypersensitive response OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to plant-type hypersensitive response, the rapid, localized death of plant cells in response to invasion by a pathogen. go.json metacaspase activity involved in plant-type hypersensitive response True http://purl.obolibrary.org/obo/GO_0097299 GO:0097298 biolink:BiologicalProcess regulation of nucleus size Any process that modulates the size of the nucleus. go.json regulation of nuclear size|regulation of nuclear volume http://purl.obolibrary.org/obo/GO_0097298 GO:0097295 biolink:BiologicalProcess morphine biosynthetic process The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum. go.json morphine anabolism|morphine biosynthesis|morphine formation|morphine synthesis http://purl.obolibrary.org/obo/GO_0097295 GO:0097294 biolink:BiologicalProcess 'de novo' XMP biosynthetic process The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors. go.json 'de novo' XMP anabolism|'de novo' XMP biosynthesis|'de novo' XMP formation|'de novo' XMP synthesis http://purl.obolibrary.org/obo/GO_0097294 GO:0097297 biolink:BiologicalProcess obsolete activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis OBSOLETE. Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis. go.json activation of effector caspase activity True http://purl.obolibrary.org/obo/GO_0097297 GO:0097296 biolink:BiologicalProcess activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. go.json activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|activation of initiator caspase activity http://purl.obolibrary.org/obo/GO_0097296 gocheck_do_not_annotate GO:0097291 biolink:BiologicalProcess renal phosphate ion absorption A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. go.json renal phosphate absorption http://purl.obolibrary.org/obo/GO_0097291 GO:0097290 biolink:BiologicalProcess alpha-ribazole biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12). go.json alpha-ribazole anabolism|alpha-ribazole biosynthesis|alpha-ribazole formation|alpha-ribazole synthesis http://purl.obolibrary.org/obo/GO_0097290 GO:0097293 biolink:BiologicalProcess XMP biosynthetic process The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate. go.json XMP anabolism|XMP biosynthesis|XMP formation|XMP synthesis http://purl.obolibrary.org/obo/GO_0097293 GO:0097292 biolink:BiologicalProcess XMP metabolic process The chemical reactions and pathways involving XMP, xanthosine monophosphate. go.json XMP metabolism http://purl.obolibrary.org/obo/GO_0097292 GO:0000321 biolink:BiologicalProcess re-entry into mitotic cell cycle after pheromone arrest The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0000321 GO:0097233 biolink:CellularComponent alveolar lamellar body membrane The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. go.json http://purl.obolibrary.org/obo/GO_0097233 GO:0097232 biolink:CellularComponent lamellar body membrane The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. go.json http://purl.obolibrary.org/obo/GO_0097232 GO:0000320 biolink:BiologicalProcess re-entry into mitotic cell cycle The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. go.json http://purl.obolibrary.org/obo/GO_0000320 GO:0097235 biolink:BiologicalProcess obsolete positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0097235 GO:0097234 biolink:CellularComponent epidermal lamellar body membrane The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. go.json http://purl.obolibrary.org/obo/GO_0097234 GO:0000325 biolink:CellularComponent plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. go.json vacuole, cell cycle-independent morphology http://purl.obolibrary.org/obo/GO_0000325 GO:0000324 biolink:CellularComponent fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. go.json vacuole, cell cycle-correlated morphology http://purl.obolibrary.org/obo/GO_0000324 GO:0097231 biolink:BiologicalProcess cell motility in response to calcium ion Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus. go.json Ca2+ facilitation of cell motility|calcium ion facilitation of cell motility http://purl.obolibrary.org/obo/GO_0097231 GO:0000323 biolink:CellularComponent lytic vacuole A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. go.json http://purl.obolibrary.org/obo/GO_0000323 GO:0097230 biolink:BiologicalProcess cell motility in response to potassium ion Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus. go.json K+ facilitation of cell motility|potassium ion facilitation of cell motility http://purl.obolibrary.org/obo/GO_0097230 GO:0000322 biolink:CellularComponent storage vacuole A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. go.json http://purl.obolibrary.org/obo/GO_0000322 GO:1903469 biolink:BiologicalProcess removal of RNA primer involved in mitotic DNA replication Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication. go.json DNA replication, removal of RNA primer involved in DNA replication during S phase involved in mitotic cell cycle|DNA replication, removal of RNA primer involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA replication, removal of RNA primer involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA replication, removal of RNA primer involved in mitotic nuclear cell cycle DNA replication|DNA replication, removal of RNA primer involved in nuclear cell cycle DNA replication involved in mitotic cell cycle|Okazaki initiator RNA removal involved in DNA replication during S phase involved in mitotic cell cycle|Okazaki initiator RNA removal involved in DNA replication involved in S phase involved in mitotic cell cycle|Okazaki initiator RNA removal involved in DNA replication involved in S-phase involved in mitotic cell cycle|Okazaki initiator RNA removal involved in mitotic cell cycle DNA replication|Okazaki initiator RNA removal involved in mitotic nuclear cell cycle DNA replication|Okazaki initiator RNA removal involved in nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903469 GO:1903468 biolink:BiologicalProcess positive regulation of DNA replication initiation Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. go.json activation of DNA replication initiation involved in mitotic DNA replication|activation of DNA replication initiation involved in mitotic cell cycle DNA replication|positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|up regulation of DNA replication initiation involved in mitotic DNA replication|up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|up-regulation of DNA replication initiation involved in mitotic DNA replication|up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|upregulation of DNA replication initiation involved in mitotic DNA replication|upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1903468 GO:1903467 biolink:BiologicalProcess negative regulation of mitotic DNA replication initiation Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. go.json down regulation of DNA replication initiation involved in mitotic DNA replication|down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|down-regulation of DNA replication initiation involved in mitotic DNA replication|down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|downregulation of DNA replication initiation involved in mitotic DNA replication|downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication|inhibition of DNA replication initiation involved in mitotic DNA replication|inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication|negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1903467 GO:1903466 biolink:BiologicalProcess regulation of mitotic DNA replication initiation Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. go.json regulation of DNA replication initiation involved in mitotic cell cycle DNA replication http://purl.obolibrary.org/obo/GO_1903466 GO:1903465 biolink:BiologicalProcess positive regulation of mitotic cell cycle DNA replication Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication. go.json activation of DNA replication during S phase involved in mitotic cell cycle|activation of DNA replication involved in S phase involved in mitotic cell cycle|activation of DNA replication involved in S-phase involved in mitotic cell cycle|activation of mitotic cell cycle DNA replication|activation of mitotic nuclear cell cycle DNA replication|activation of nuclear cell cycle DNA replication involved in mitotic cell cycle|positive regulation of DNA replication during S phase involved in mitotic cell cycle|positive regulation of DNA replication involved in S phase involved in mitotic cell cycle|positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle|positive regulation of mitotic nuclear cell cycle DNA replication|positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|up regulation of DNA replication during S phase involved in mitotic cell cycle|up regulation of DNA replication involved in S phase involved in mitotic cell cycle|up regulation of DNA replication involved in S-phase involved in mitotic cell cycle|up regulation of mitotic cell cycle DNA replication|up regulation of mitotic nuclear cell cycle DNA replication|up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|up-regulation of DNA replication during S phase involved in mitotic cell cycle|up-regulation of DNA replication involved in S phase involved in mitotic cell cycle|up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle|up-regulation of mitotic cell cycle DNA replication|up-regulation of mitotic nuclear cell cycle DNA replication|up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|upregulation of DNA replication during S phase involved in mitotic cell cycle|upregulation of DNA replication involved in S phase involved in mitotic cell cycle|upregulation of DNA replication involved in S-phase involved in mitotic cell cycle|upregulation of mitotic cell cycle DNA replication|upregulation of mitotic nuclear cell cycle DNA replication|upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903465 GO:1903464 biolink:BiologicalProcess negative regulation of mitotic cell cycle DNA replication Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication. go.json down regulation of DNA replication during S phase involved in mitotic cell cycle|down regulation of DNA replication involved in S phase involved in mitotic cell cycle|down regulation of DNA replication involved in S-phase involved in mitotic cell cycle|down regulation of mitotic cell cycle DNA replication|down regulation of mitotic nuclear cell cycle DNA replication|down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|down-regulation of DNA replication during S phase involved in mitotic cell cycle|down-regulation of DNA replication involved in S phase involved in mitotic cell cycle|down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle|down-regulation of mitotic cell cycle DNA replication|down-regulation of mitotic nuclear cell cycle DNA replication|down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|downregulation of DNA replication during S phase involved in mitotic cell cycle|downregulation of DNA replication involved in S phase involved in mitotic cell cycle|downregulation of DNA replication involved in S-phase involved in mitotic cell cycle|downregulation of mitotic cell cycle DNA replication|downregulation of mitotic nuclear cell cycle DNA replication|downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|inhibition of DNA replication during S phase involved in mitotic cell cycle|inhibition of DNA replication involved in S phase involved in mitotic cell cycle|inhibition of DNA replication involved in S-phase involved in mitotic cell cycle|inhibition of mitotic cell cycle DNA replication|inhibition of mitotic nuclear cell cycle DNA replication|inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle|negative regulation of DNA replication during S phase involved in mitotic cell cycle|negative regulation of DNA replication involved in S phase involved in mitotic cell cycle|negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle|negative regulation of mitotic nuclear cell cycle DNA replication|negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903464 GO:1903474 biolink:BiologicalProcess obsolete anchoring of the mitotic actomyosin contractile ring to the plasma membrane OBSOLETE. A process that maintains the mitotic actinomyosin contractile ring at the plasma membrane. go.json cytokinetic ring anchoring involved in mitotic cell cycle|maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle True http://purl.obolibrary.org/obo/GO_1903474 GO:1903473 biolink:BiologicalProcess positive regulation of mitotic actomyosin contractile ring contraction Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction. go.json activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|activation of mitotic actomyosin contractile ring contraction|positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|positive regulation of mitotic actomyosin contractile ring constriction|up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|up regulation of mitotic actomyosin contractile ring contraction|up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|up-regulation of mitotic actomyosin contractile ring contraction|upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|upregulation of mitotic actomyosin contractile ring contraction http://purl.obolibrary.org/obo/GO_1903473 GO:1903472 biolink:BiologicalProcess negative regulation of mitotic actomyosin contractile ring contraction Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring contraction. go.json down regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|down regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|down regulation of mitotic actomyosin contractile ring contraction|down-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|down-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|down-regulation of mitotic actomyosin contractile ring contraction|downregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|downregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|downregulation of mitotic actomyosin contractile ring contraction|inhibition of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|inhibition of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|inhibition of mitotic actomyosin contractile ring contraction|negative regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|negative regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|negative regulation of mitotic actomyosin contractile ring constriction http://purl.obolibrary.org/obo/GO_1903472 GO:1903471 biolink:BiologicalProcess regulation of mitotic actomyosin contractile ring contraction Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction. go.json regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|regulation of mitotic actomyosin contractile ring constriction http://purl.obolibrary.org/obo/GO_1903471 GO:1903470 biolink:BiologicalProcess obsolete actomyosin contractile ring assembly involved in mitotic cell cycle OBSOLETE. Any actomyosin contractile ring assembly that is involved in mitotic cell cycle. go.json constriction ring assembly involved in mitotic cell cycle|contractile ring assembly involved in mitotic cell cycle|cytokinesis, actomyosin contractile ring assembly involved in mitotic cell cycle|cytokinesis, actomyosin contractile ring formation involved in mitotic cell cycle|cytokinesis, actomyosin ring biosynthesis involved in mitotic cell cycle|cytokinesis, actomyosin ring formation involved in mitotic cell cycle|cytokinesis, contractile ring assembly involved in mitotic cell cycle True http://purl.obolibrary.org/obo/GO_1903470 GO:0000329 biolink:CellularComponent fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. go.json fungal-type vacuolar membrane|membrane of vacuole with cell cycle-correlated morphology http://purl.obolibrary.org/obo/GO_0000329 GO:0000328 biolink:CellularComponent fungal-type vacuole lumen The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae. go.json lumen of vacuole with cell cycle-correlated morphology http://purl.obolibrary.org/obo/GO_0000328 GO:0000327 biolink:CellularComponent lytic vacuole within protein storage vacuole A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole. go.json http://purl.obolibrary.org/obo/GO_0000327 GO:0000326 biolink:CellularComponent protein storage vacuole A storage vacuole that contains a lytic vacuole; identified in plants. go.json http://purl.obolibrary.org/obo/GO_0000326 GO:0097237 biolink:BiologicalProcess cellular response to toxic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. go.json http://purl.obolibrary.org/obo/GO_0097237 GO:0097236 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions. go.json True http://purl.obolibrary.org/obo/GO_0097236 GO:0097239 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus. go.json True http://purl.obolibrary.org/obo/GO_0097239 GO:0097238 biolink:BiologicalProcess cellular response to methylglyoxal Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. go.json http://purl.obolibrary.org/obo/GO_0097238 GO:0097244 biolink:MolecularActivity flavonol binding Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone. go.json http://purl.obolibrary.org/obo/GO_0097244 GO:0000332 biolink:MolecularActivity template for synthesis of G-rich strand of telomere DNA activity Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA. go.json telomerase RNA|telomerase, template http://purl.obolibrary.org/obo/GO_0000332 GO:0000331 biolink:CellularComponent contractile vacuole A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory. Wikipedia:Contractile_vacuole go.json central bladder|central vacuole http://purl.obolibrary.org/obo/GO_0000331 GO:0097243 biolink:MolecularActivity flavonoid binding Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge. go.json http://purl.obolibrary.org/obo/GO_0097243 GO:0097246 biolink:MolecularActivity catechin binding Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure. go.json http://purl.obolibrary.org/obo/GO_0097246 GO:0000330 biolink:CellularComponent plant-type vacuole lumen The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana. go.json lumen of vacuole with cell cycle-independent morphology http://purl.obolibrary.org/obo/GO_0000330 GO:0097245 biolink:MolecularActivity flavanol binding Binding to a flavanol. go.json flavan-3-ol binding http://purl.obolibrary.org/obo/GO_0097245 GO:0097240 biolink:BiologicalProcess chromosome attachment to the nuclear envelope The process in which chromatin is anchored to the nuclear envelope. go.json attachment of chromatin to nuclear envelope http://purl.obolibrary.org/obo/GO_0097240 GO:0000336 biolink:BiologicalProcess obsolete positive regulation of transposition, DNA-mediated OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA transposition. go.json activation of DNA transposition|positive regulation of DNA transposition|stimulation of DNA transposition|up regulation of DNA transposition|up-regulation of DNA transposition|upregulation of DNA transposition True http://purl.obolibrary.org/obo/GO_0000336 GO:0000335 biolink:BiologicalProcess obsolete negative regulation of transposition, DNA-mediated OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition. go.json down regulation of DNA transposition|down-regulation of DNA transposition|downregulation of DNA transposition|inhibition of DNA transposition|negative regulation of DNA transposition True http://purl.obolibrary.org/obo/GO_0000335 GO:0000334 biolink:MolecularActivity 3-hydroxyanthranilate 3,4-dioxygenase activity Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+. EC:1.13.11.6|KEGG_REACTION:R02665|MetaCyc:1.13.11.6-RXN|RHEA:17953|Reactome:R-HSA-71218|UM-BBD_reactionID:r1027 go.json 3-hydroxyanthranilate oxygenase activity|3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)|3-hydroxyanthranilic acid dioxygenase activity|3-hydroxyanthranilic acid oxygenase activity|3-hydroxyanthranilic oxygenase activity|3HAO http://purl.obolibrary.org/obo/GO_0000334 GO:0097242 biolink:BiologicalProcess amyloid-beta clearance The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors. go.json beta-amyloid clearance http://purl.obolibrary.org/obo/GO_0097242 GO:0097241 biolink:BiologicalProcess hematopoietic stem cell migration to bone marrow The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. go.json hematopoietic stem cell homing|hemopoietic stem cell migration to bone marrow|progenitor cell homing http://purl.obolibrary.org/obo/GO_0097241 GO:0000333 biolink:CellularComponent telomerase catalytic core complex The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. go.json TERT-TERC complex http://purl.obolibrary.org/obo/GO_0000333 GO:1903479 biolink:BiologicalProcess mitotic actomyosin contractile ring assembly actin filament organization Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly. go.json actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|actin filament organisation involved in mitotic actomyosin contractile ring assembly|actin filament organization involved in mitotic actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_1903479 GO:1903478 biolink:BiologicalProcess obsolete actin filament bundle convergence involved in mitotic contractile ring assembly OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly. go.json actin filament bundle convergence involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis|actin filament bundle convergence involved in contractile ring assembly involved in mitotic cytokinesis|actin filament bundle convergence involved in cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|actin filament bundle convergence involved in mitotic actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1903478 GO:1903477 biolink:BiologicalProcess mitotic contractile ring actin filament bundle assembly Any actin filament bundle assembly that is involved in mitotic actomyosin contractile ring assembly. go.json actin filament bundle assembly involved in mitotic actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_1903477 GO:1903476 biolink:BiologicalProcess protein localization to cell division site involved in mitotic actomyosin contractile ring assembly Any protein localization to cell division site that is involved in mitotic actomyosin contractile ring assembly. go.json protein localisation to cell division site involved in mitotic actomyosin contractile ring assembly|protein localization to cell division site involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis|protein localization to cell division site involved in contractile ring assembly involved in mitotic cytokinesis http://purl.obolibrary.org/obo/GO_1903476 GO:1903475 biolink:BiologicalProcess mitotic actomyosin contractile ring assembly Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis. go.json actomyosin contractile ring assembly involved in cytokinesis after mitosis|contractile ring assembly involved in mitotic cytokinesis|cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis http://purl.obolibrary.org/obo/GO_1903475 GO:1903485 biolink:BiologicalProcess obsolete positive regulation of maintenance of mitotic actomyosin contractile ring localization OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization. go.json activation of cytokinetic ring anchoring involved in mitotic cell cycle|activation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|activation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|activation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|activation of maintenance of mitotic actomyosin contractile ring localization|positive regulation of cytokinetic ring anchoring involved in mitotic cell cycle|positive regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|positive regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|positive regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|up regulation of cytokinetic ring anchoring involved in mitotic cell cycle|up regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|up regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|up regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|up regulation of maintenance of mitotic actomyosin contractile ring localization|up-regulation of cytokinetic ring anchoring involved in mitotic cell cycle|up-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|up-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|up-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|up-regulation of maintenance of mitotic actomyosin contractile ring localization|upregulation of cytokinetic ring anchoring involved in mitotic cell cycle|upregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|upregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|upregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|upregulation of maintenance of mitotic actomyosin contractile ring localization True http://purl.obolibrary.org/obo/GO_1903485 GO:1903484 biolink:BiologicalProcess obsolete negative regulation of maintenance of mitotic actomyosin contractile ring localization OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization. go.json down regulation of cytokinetic ring anchoring involved in mitotic cell cycle|down regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|down regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|down regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|down regulation of maintenance of mitotic actomyosin contractile ring localization|down-regulation of cytokinetic ring anchoring involved in mitotic cell cycle|down-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|down-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|down-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|down-regulation of maintenance of mitotic actomyosin contractile ring localization|downregulation of cytokinetic ring anchoring involved in mitotic cell cycle|downregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|downregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|downregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|downregulation of maintenance of mitotic actomyosin contractile ring localization|inhibition of cytokinetic ring anchoring involved in mitotic cell cycle|inhibition of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|inhibition of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|inhibition of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle|inhibition of maintenance of mitotic actomyosin contractile ring localization|negative regulation of cytokinetic ring anchoring involved in mitotic cell cycle|negative regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|negative regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|negative regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle True http://purl.obolibrary.org/obo/GO_1903484 GO:1903483 biolink:BiologicalProcess obsolete regulation of maintenance of mitotic actomyosin contractile ring localization OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization. go.json regulation of cytokinetic ring anchoring involved in mitotic cell cycle|regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle|regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle True http://purl.obolibrary.org/obo/GO_1903483 GO:1903482 biolink:BiologicalProcess obsolete positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. go.json activation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|activation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|activation of actin filament organization involved in mitotic actomyosin contractile ring assembly|positive regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|positive regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|up regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|up regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|up regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|up-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|up-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|up-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|upregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|upregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|upregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1903482 GO:1903481 biolink:BiologicalProcess obsolete negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. go.json down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly|inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly|negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1903481 GO:1903480 biolink:BiologicalProcess obsolete regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly OBSOLETE. Any process that modulates the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. go.json regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly True http://purl.obolibrary.org/obo/GO_1903480 GO:0000339 biolink:MolecularActivity RNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. go.json binding to mRNA cap|mRNA cap binding|snRNA cap binding http://purl.obolibrary.org/obo/GO_0000339 GO:0000338 biolink:BiologicalProcess protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein. go.json cullin deneddylation http://purl.obolibrary.org/obo/GO_0000338 GO:0000337 biolink:BiologicalProcess obsolete regulation of transposition, DNA-mediated OBSOLETE. Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule. go.json regulation of DNA transposition True http://purl.obolibrary.org/obo/GO_0000337 GO:0097248 biolink:BiologicalProcess maintenance of protein location in cell cortex of cell tip A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell. go.json http://purl.obolibrary.org/obo/GO_0097248 GO:0097247 biolink:MolecularActivity epigallocatechin 3-gallate binding Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin. go.json EGCG binding|catechin gallate binding http://purl.obolibrary.org/obo/GO_0097247 GO:0097249 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097249 GO:0097211 biolink:BiologicalProcess cellular response to gonadotropin-releasing hormone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. go.json cellular response to GnRH|cellular response to gonadotrophin-releasing hormone http://purl.obolibrary.org/obo/GO_0097211 GO:0097210 biolink:BiologicalProcess response to gonadotropin-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. go.json response to GnRH http://purl.obolibrary.org/obo/GO_0097210 GO:0097213 biolink:BiologicalProcess regulation of lysosomal membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. go.json regulation of lysosome membrane permeability http://purl.obolibrary.org/obo/GO_0097213 GO:0097212 biolink:BiologicalProcess lysosomal membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. go.json lysosomal membrane organisation|lysosome membrane organization http://purl.obolibrary.org/obo/GO_0097212 GO:0000303 biolink:BiologicalProcess response to superoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. go.json http://purl.obolibrary.org/obo/GO_0000303 GO:0000302 biolink:BiologicalProcess response to reactive oxygen species Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. go.json response to AOS|response to ROI|response to ROS|response to active oxygen species|response to reactive oxidative species|response to reactive oxygen intermediate http://purl.obolibrary.org/obo/GO_0000302 GO:0000301 biolink:BiologicalProcess retrograde transport, vesicle recycling within Golgi The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. go.json retrograde (vesicle recycling within Golgi) transport http://purl.obolibrary.org/obo/GO_0000301 GO:0000300 biolink:CellularComponent obsolete peripheral to membrane of membrane fraction OBSOLETE. Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH. go.json peripheral to membrane of membrane fraction True http://purl.obolibrary.org/obo/GO_0000300 GO:1903489 biolink:BiologicalProcess positive regulation of lactation Any process that activates or increases the frequency, rate or extent of lactation. go.json activation of lactation|up regulation of lactation|up-regulation of lactation|upregulation of lactation http://purl.obolibrary.org/obo/GO_1903489 GO:1903488 biolink:BiologicalProcess negative regulation of lactation Any process that stops, prevents or reduces the frequency, rate or extent of lactation. go.json down regulation of lactation|down-regulation of lactation|downregulation of lactation|inhibition of lactation http://purl.obolibrary.org/obo/GO_1903488 GO:1903487 biolink:BiologicalProcess regulation of lactation Any process that modulates the frequency, rate or extent of lactation. go.json http://purl.obolibrary.org/obo/GO_1903487 GO:1903486 biolink:BiologicalProcess obsolete establishment of mitotic actomyosin contractile ring localization OBSOLETE. Any establishment of actomyosin contractile ring localization that is involved in mitotic cell cycle. go.json True http://purl.obolibrary.org/obo/GO_1903486 GO:1903496 biolink:BiologicalProcess response to 11-deoxycorticosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_1903496 GO:1903495 biolink:BiologicalProcess cellular response to dehydroepiandrosterone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_1903495 GO:1903494 biolink:BiologicalProcess response to dehydroepiandrosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_1903494 GO:1903493 biolink:BiologicalProcess response to clopidogrel Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. go.json http://purl.obolibrary.org/obo/GO_1903493 GO:1903492 biolink:BiologicalProcess response to acetylsalicylate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity. go.json http://purl.obolibrary.org/obo/GO_1903492 GO:1903491 biolink:BiologicalProcess response to simvastatin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug. go.json http://purl.obolibrary.org/obo/GO_1903491 gocheck_do_not_manually_annotate GO:1903490 biolink:BiologicalProcess positive regulation of mitotic cytokinesis Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis. go.json activation of cytokinesis after mitosis|activation of mitotic cytokinesis|positive regulation of cytokinesis after mitosis|up regulation of cytokinesis after mitosis|up regulation of mitotic cytokinesis|up-regulation of cytokinesis after mitosis|up-regulation of mitotic cytokinesis|upregulation of cytokinesis after mitosis|upregulation of mitotic cytokinesis http://purl.obolibrary.org/obo/GO_1903490 GO:0000307 biolink:CellularComponent cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. go.json CDK holoenzyme http://purl.obolibrary.org/obo/GO_0000307 goslim_pir GO:0097219 biolink:CellularComponent compound sieve plate A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement. go.json http://purl.obolibrary.org/obo/GO_0097219 GO:0000306 biolink:CellularComponent obsolete extrinsic component of vacuolar membrane OBSOLETE. The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to vacuolar membrane True http://purl.obolibrary.org/obo/GO_0000306 GO:0097218 biolink:CellularComponent sieve plate A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas. go.json http://purl.obolibrary.org/obo/GO_0097218 GO:0000305 biolink:BiologicalProcess response to oxygen radical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. go.json http://purl.obolibrary.org/obo/GO_0000305 GO:0000304 biolink:BiologicalProcess response to singlet oxygen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. go.json http://purl.obolibrary.org/obo/GO_0000304 GO:0097215 biolink:BiologicalProcess negative regulation of lysosomal membrane permeability Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. go.json negative regulation of lysosome membrane permeability http://purl.obolibrary.org/obo/GO_0097215 GO:0097214 biolink:BiologicalProcess positive regulation of lysosomal membrane permeability Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. go.json positive regulation of lysosome membrane permeability http://purl.obolibrary.org/obo/GO_0097214 GO:0097217 biolink:CellularComponent sieve area A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements. go.json http://purl.obolibrary.org/obo/GO_0097217 GO:0000309 biolink:MolecularActivity nicotinamide-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. EC:2.7.7.1|MetaCyc:2.7.7.1-RXN|RHEA:21360|Reactome:R-HSA-8939959 go.json ATP:NMN adenylyltransferase activity|ATP:nicotinamide-nucleotide adenylyltransferase activity|NAD(+) diphosphorylase activity|NAD(+) pyrophosphorylase activity|NAD+ diphosphorylase activity|NAD+ pyrophosphorylase activity|NMN adenylyltransferase activity|NMNAT activity|adenosine triphosphate-nicotinamide mononucleotide transadenylase activity|diphosphopyridine nucleotide pyrophosphorylase activity|nicotinamide adenine dinucleotide pyrophosphorylase activity|nicotinamide mononucleotide adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0000309 GO:0097216 biolink:MolecularActivity guanosine tetraphosphate binding Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions. go.json 5'-ppGpp-3' binding http://purl.obolibrary.org/obo/GO_0097216 GO:0000308 biolink:CellularComponent cytoplasmic cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm. go.json CDK holoenzyme http://purl.obolibrary.org/obo/GO_0000308 GO:0097222 biolink:BiologicalProcess mitochondrial mRNA polyadenylation The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails. go.json http://purl.obolibrary.org/obo/GO_0097222 GO:0000310 biolink:MolecularActivity xanthine phosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate. EC:2.4.2.22|MetaCyc:XANPRIBOSYLTRAN-RXN|RHEA:10800 go.json 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity|XMP pyrophosphorylase activity|XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity|Xan phosphoribosyltransferase activity|xanthine-guanine phosphoribosyltransferase activity|xanthosine 5'-phosphate pyrophosphorylase activity|xanthylate pyrophosphorylase activity|xanthylic pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0000310 GO:0097221 biolink:CellularComponent M/G1 phase-specific MADS box-forkhead transcription factor complex A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2. go.json PBF complex|PBF transcription complex|PCB binding factor complex|pombe cell cycle box binding factor complex http://purl.obolibrary.org/obo/GO_0097221 GO:0097224 biolink:CellularComponent sperm connecting piece The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum. go.json http://purl.obolibrary.org/obo/GO_0097224 GO:0097223 biolink:CellularComponent obsolete sperm part OBSOLETE. Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. go.json True http://purl.obolibrary.org/obo/GO_0097223 GO:0000314 biolink:CellularComponent organellar small ribosomal subunit The smaller of the two subunits of an organellar ribosome. go.json http://purl.obolibrary.org/obo/GO_0000314 GO:0000313 biolink:CellularComponent organellar ribosome A ribosome contained within a subcellular membrane-bounded organelle. go.json http://purl.obolibrary.org/obo/GO_0000313 GO:0097220 biolink:CellularComponent simple sieve plate A sieve plate that contains a single specialized sieve area. go.json http://purl.obolibrary.org/obo/GO_0097220 GO:0000312 biolink:CellularComponent plastid small ribosomal subunit The smaller of the two subunits of a plastid ribosome. go.json http://purl.obolibrary.org/obo/GO_0000312 GO:0000311 biolink:CellularComponent plastid large ribosomal subunit The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). go.json http://purl.obolibrary.org/obo/GO_0000311 GO:1903499 biolink:BiologicalProcess regulation of mitotic actomyosin contractile ring assembly Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring assembly. go.json regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis|regulation of contractile ring assembly involved in mitotic cytokinesis|regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis|regulation of mitotic cytokinesis, actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_1903499 GO:1903498 biolink:BiologicalProcess bundle sheath cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a bundle sheath cell. go.json http://purl.obolibrary.org/obo/GO_1903498 GO:1903497 biolink:BiologicalProcess cellular response to 11-deoxycorticosterone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_1903497 GO:0000318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000318 GO:0000317 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000317 GO:0097229 biolink:CellularComponent sperm end piece The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0097229 GO:0000316 biolink:BiologicalProcess sulfite transport The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json sulphite transport http://purl.obolibrary.org/obo/GO_0000316 GO:0000315 biolink:CellularComponent organellar large ribosomal subunit The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). go.json http://purl.obolibrary.org/obo/GO_0000315 GO:0097226 biolink:CellularComponent sperm mitochondrial sheath The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. go.json http://purl.obolibrary.org/obo/GO_0097226 GO:0097225 biolink:CellularComponent sperm midpiece The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. go.json http://purl.obolibrary.org/obo/GO_0097225 GO:0097228 biolink:CellularComponent sperm principal piece The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. go.json http://purl.obolibrary.org/obo/GO_0097228 GO:0097227 biolink:CellularComponent sperm annulus The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity. go.json http://purl.obolibrary.org/obo/GO_0097227 GO:0000319 biolink:MolecularActivity sulfite transmembrane transporter activity Enables the transfer of sulfite ions from one side of a membrane to the other. go.json sulphite transporter activity http://purl.obolibrary.org/obo/GO_0000319 GO:0097277 biolink:BiologicalProcess obsolete cellular urea homeostasis OBSOLETE. Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell. go.json True http://purl.obolibrary.org/obo/GO_0097277 GO:0097276 biolink:BiologicalProcess obsolete cellular creatinine homeostasis OBSOLETE. Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell. go.json True http://purl.obolibrary.org/obo/GO_0097276 GO:0097279 biolink:BiologicalProcess histamine secretion mediated by IgE immunoglobulin Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen. go.json Ig-mediated histamine release|histamine secretion mediated by IgE antibody http://purl.obolibrary.org/obo/GO_0097279 GO:0097278 biolink:BiologicalProcess complement-dependent cytotoxicity Cell killing caused by the membrane attack complex formed following complement activation. go.json http://purl.obolibrary.org/obo/GO_0097278 GO:0097273 biolink:BiologicalProcess obsolete creatinine homeostasis OBSOLETE. Any biological process involved in the maintenance of an internal steady state of creatinine. go.json True http://purl.obolibrary.org/obo/GO_0097273 GO:0097272 biolink:BiologicalProcess ammonium homeostasis Any biological process involved in the maintenance of an internal steady state of ammonium. go.json ammonia homeostasis http://purl.obolibrary.org/obo/GO_0097272 GO:0097275 biolink:BiologicalProcess intracellular ammonium homeostasis A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell. go.json cellular ammonia homeostasis|cellular ammonium homeostasis http://purl.obolibrary.org/obo/GO_0097275 GO:0097274 biolink:BiologicalProcess obsolete urea homeostasis OBSOLETE. Any biological process involved in the maintenance of an internal steady state of urea. go.json True http://purl.obolibrary.org/obo/GO_0097274 GO:0097271 biolink:BiologicalProcess protein localization to bud neck A process in which a protein is transported to, or maintained at, a location within a cellular bud neck. go.json protein localisation to bud neck|protein localization to cellular bud neck http://purl.obolibrary.org/obo/GO_0097271 GO:0097270 biolink:BiologicalProcess dishabituation The temporary recovery of response to a stimulus when a novel stimulus is added. go.json http://purl.obolibrary.org/obo/GO_0097270 GO:0097288 biolink:BiologicalProcess 7-cyano-7-deazaguanine biosynthetic process The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo. go.json 7-cyano-7-deazaguanine anabolism|7-cyano-7-deazaguanine biosynthesis|7-cyano-7-deazaguanine formation|7-cyano-7-deazaguanine synthesis http://purl.obolibrary.org/obo/GO_0097288 GO:0097287 biolink:BiologicalProcess 7-cyano-7-deazaguanine metabolic process The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo. go.json 7-cyano-7-deazaguanine metabolism http://purl.obolibrary.org/obo/GO_0097287 GO:0097289 biolink:BiologicalProcess alpha-ribazole metabolic process The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12). go.json alpha-ribazole metabolism http://purl.obolibrary.org/obo/GO_0097289 GO:0097284 biolink:BiologicalProcess hepatocyte apoptotic process Any apoptotic process in a hepatocyte, the main structural component of the liver. go.json hepatocyte apoptosis http://purl.obolibrary.org/obo/GO_0097284 GO:0097283 biolink:BiologicalProcess keratinocyte apoptotic process Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. go.json keratinocyte apoptosis http://purl.obolibrary.org/obo/GO_0097283 GO:0097286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097286 GO:0097285 biolink:BiologicalProcess obsolete cell-type specific apoptotic process OBSOLETE. Any apoptotic process in a specific cell type. go.json cell-type specific apoptosis True http://purl.obolibrary.org/obo/GO_0097285 GO:0097280 biolink:BiologicalProcess histamine secretion mediated by immunoglobulin Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface. go.json http://purl.obolibrary.org/obo/GO_0097280 GO:0097282 biolink:BiologicalProcess immunoglobulin-mediated neutralization The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin. go.json antibody-mediated neutralization http://purl.obolibrary.org/obo/GO_0097282 GO:0097281 biolink:BiologicalProcess immune complex formation The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus. go.json antibody-mediated agglutination http://purl.obolibrary.org/obo/GO_0097281 GO:0097255 biolink:CellularComponent R2TP complex A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. go.json http://purl.obolibrary.org/obo/GO_0097255 GO:0097254 biolink:BiologicalProcess renal tubular secretion The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. go.json http://purl.obolibrary.org/obo/GO_0097254 GO:0097257 biolink:MolecularActivity leukotriene B4 12-hydroxy dehydrogenase activity Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+. RHEA:50608|Reactome:R-HSA-2161567 go.json leukotriene B4 12-hydroxydehydrogenase activity http://purl.obolibrary.org/obo/GO_0097257 GO:0014909 biolink:BiologicalProcess smooth muscle cell migration The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. go.json http://purl.obolibrary.org/obo/GO_0014909 GO:0097256 biolink:MolecularActivity phenyllactate dehydrogenase activity Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH. RHEA:38351 go.json http://purl.obolibrary.org/obo/GO_0097256 GO:0097251 biolink:BiologicalProcess leukotriene B4 biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. go.json LTB4 anabolism|LTB4 biosynthesis|LTB4 formation|LTB4 synthesis|leukotriene B4 anabolism|leukotriene B4 biosynthesis|leukotriene B4 formation|leukotriene B4 synthesis http://purl.obolibrary.org/obo/GO_0097251 GO:0097250 biolink:BiologicalProcess mitochondrial respirasome assembly The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex. go.json mitochondrial respiratory chain supercomplex assembly|mitochondrial respiratory supercomplex assembly http://purl.obolibrary.org/obo/GO_0097250 GO:0097253 biolink:MolecularActivity beta-hydroxybutyrate transmembrane transporter activity Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid. go.json (R)-3-hydroxybutyrate transmembrane transporter activity|3-hydroxybutanoic acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0097253 GO:0097252 biolink:BiologicalProcess oligodendrocyte apoptotic process Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons. go.json oligodendrocyte apoptosis http://purl.obolibrary.org/obo/GO_0097252 GO:0014904 biolink:BiologicalProcess myotube cell development The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0014904 GO:0014902 biolink:BiologicalProcess myotube differentiation The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0014902 GO:0014901 biolink:BiologicalProcess satellite cell activation involved in skeletal muscle regeneration The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. go.json http://purl.obolibrary.org/obo/GO_0014901 GO:0014908 biolink:BiologicalProcess myotube differentiation involved in skeletal muscle regeneration The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0014908 GO:0014906 biolink:BiologicalProcess myotube cell development involved in skeletal muscle regeneration The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. go.json http://purl.obolibrary.org/obo/GO_0014906 GO:0014905 biolink:BiologicalProcess myoblast fusion involved in skeletal muscle regeneration A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014905 GO:0014900 biolink:BiologicalProcess muscle hyperplasia A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ. go.json http://purl.obolibrary.org/obo/GO_0014900 GO:0097259 biolink:MolecularActivity 20-aldehyde-leukotriene B4 20-monooxygenase activity Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]. RHEA:48672|Reactome:R-HSA-2161792|Reactome:R-HSA-2161979 go.json http://purl.obolibrary.org/obo/GO_0097259 GO:0097258 biolink:MolecularActivity 20-hydroxy-leukotriene B4 omega oxidase activity Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]. RHEA:48668|Reactome:R-HSA-2161745 go.json 20-hydroxy-leukotriene B4 omega-oxidase activity|20-hydroxy-leukotriene B4 omega-oxidation http://purl.obolibrary.org/obo/GO_0097258 GO:0097266 biolink:MolecularActivity phenylacetyl-CoA 1,2-epoxidase activity Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+. EC:1.14.13.149|KEGG_REACTION:R09838|RHEA:32171 go.json phenylacetyl-CoA epoxidase activity|phenylacetyl-CoA monooxygenase activity|ring 1,2-phenylacetyl-CoA epoxidase activity http://purl.obolibrary.org/obo/GO_0097266 GO:0097265 biolink:MolecularActivity 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+. Reactome:R-HSA-2161776 go.json 5(S)-HETE dehydrogenase activity|5-HETE dehydrogenase activity|5-hydroxy-eicosatetraenoic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0097265 GO:0097268 biolink:CellularComponent cytoophidium A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. go.json http://purl.obolibrary.org/obo/GO_0097268 GO:0097267 biolink:BiologicalProcess omega-hydroxylase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. go.json P450 omega-hydroxylase pathway http://purl.obolibrary.org/obo/GO_0097267 GO:0097262 biolink:MolecularActivity eoxin D4 synthase activity Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid. Reactome:R-HSA-2161945 go.json http://purl.obolibrary.org/obo/GO_0097262 GO:0097261 biolink:MolecularActivity eoxin C4 synthase activity Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4. Reactome:R-HSA-2161768 go.json http://purl.obolibrary.org/obo/GO_0097261 GO:0097264 biolink:BiologicalProcess self proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. go.json autolysis|self-proteolysis http://purl.obolibrary.org/obo/GO_0097264 GO:0097263 biolink:MolecularActivity eoxin E4 synthase activity Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine. Reactome:R-HSA-2161868 go.json http://purl.obolibrary.org/obo/GO_0097263 GO:0014915 biolink:BiologicalProcess regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014915 GO:0014914 biolink:BiologicalProcess myoblast maturation involved in muscle regeneration A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014914 GO:0097260 biolink:MolecularActivity eoxin A4 synthase activity Catalysis of the reaction: leukotriene A4 = eoxin A4. Reactome:R-HSA-2162019 go.json http://purl.obolibrary.org/obo/GO_0097260 GO:0014912 biolink:BiologicalProcess negative regulation of smooth muscle cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. go.json http://purl.obolibrary.org/obo/GO_0014912 GO:0014918 biolink:BiologicalProcess obsolete positive regulation of natriuresis by pressure natriuresis OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis. go.json positive regulation of natriuresis by pressure natriuresis True http://purl.obolibrary.org/obo/GO_0014918 GO:0014917 biolink:BiologicalProcess obsolete positive regulation of diuresis by pressure natriuresis OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis. go.json positive regulation of diuresis by pressure natriuresis True http://purl.obolibrary.org/obo/GO_0014917 GO:0014916 biolink:BiologicalProcess regulation of lung blood pressure The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure. go.json regulation of pulmonary blood pressure http://purl.obolibrary.org/obo/GO_0014916 GO:0014911 biolink:BiologicalProcess positive regulation of smooth muscle cell migration Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. go.json http://purl.obolibrary.org/obo/GO_0014911 GO:0014910 biolink:BiologicalProcess regulation of smooth muscle cell migration Any process that modulates the frequency, rate or extent of smooth muscle cell migration. go.json http://purl.obolibrary.org/obo/GO_0014910 GO:0097269 biolink:MolecularActivity all-trans-decaprenyl-diphosphate synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate. EC:2.5.1.91|RHEA:27802|Reactome:R-HSA-2162253 go.json (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity|2-trans,6-trans-farnesyl diphosphate activity http://purl.obolibrary.org/obo/GO_0097269 GO:0000288 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. go.json deadenylation-dependent mRNA decay|mRNA breakdown, deadenylation-dependent decay|mRNA catabolic process, deadenylation-dependent|mRNA catabolic process, deadenylylation-dependent|mRNA catabolism, deadenylation-dependent|mRNA catabolism, deadenylylation-dependent|mRNA degradation, deadenylation-dependent decay|nuclear mRNA catabolic process, deadenylation-dependent decay http://purl.obolibrary.org/obo/GO_0000288 GO:0048222 biolink:CellularComponent glycoprotein network An extracellular matrix part that consists of cross-linked glycoproteins. Wikipedia:Extensin go.json extensin http://purl.obolibrary.org/obo/GO_0048222 GO:0000287 biolink:MolecularActivity magnesium ion binding Binding to a magnesium (Mg) ion. go.json Mg binding|magnesium binding http://purl.obolibrary.org/obo/GO_0000287 GO:0048221 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048221 GO:0000286 biolink:MolecularActivity alanine dehydrogenase activity Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+. EC:1.4.1.1|MetaCyc:ALANINE-DEHYDROGENASE-RXN|RHEA:18405 go.json AlaDH|L-alanine dehydrogenase activity|L-alanine:NAD+ oxidoreductase (deaminating)|NAD-dependent alanine dehydrogenase activity|NAD-linked alanine dehydrogenase activity|NADH-dependent alanine dehydrogenase activity|alanine oxidoreductase activity|alpha-alanine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0000286 GO:0048220 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048220 GO:0000285 biolink:MolecularActivity 1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+. EC:2.7.1.150|KEGG_REACTION:R05802|MetaCyc:2.7.1.150-RXN|RHEA:13609|Reactome:R-HSA-1675910|Reactome:R-HSA-1675921|Reactome:R-HSA-1676134|Reactome:R-HSA-1676168 go.json ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity|phosphatidylinositol 3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate 5-kinase activity|type III PIP kinase activity http://purl.obolibrary.org/obo/GO_0000285 GO:0000289 biolink:BiologicalProcess nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. go.json 3' to 5' mRNA deadenylation|mRNA deadenylation|nuclear mRNA poly(A) tail shortening http://purl.obolibrary.org/obo/GO_0000289 GO:0000280 biolink:BiologicalProcess nuclear division The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. go.json karyokinesis http://purl.obolibrary.org/obo/GO_0000280 goslim_pir GO:0048229 biolink:BiologicalProcess gametophyte development The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana. go.json gametogenesis http://purl.obolibrary.org/obo/GO_0048229 GO:0048228 biolink:BiologicalProcess obsolete actin cortical patch distribution OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells. go.json actin cortical patch distribution True http://purl.obolibrary.org/obo/GO_0048228 GO:0048227 biolink:BiologicalProcess plasma membrane to endosome transport Transport of a vesicle from the plasma membrane to the endosome. go.json http://purl.obolibrary.org/obo/GO_0048227 GO:0000284 biolink:BiologicalProcess obsolete shmoo orientation OBSOLETE. (Was not defined before being made obsolete). go.json shmoo orientation True http://purl.obolibrary.org/obo/GO_0000284 GO:0048226 biolink:CellularComponent Casparian strip Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants. Wikipedia:Casparian_strip go.json http://purl.obolibrary.org/obo/GO_0048226 GO:0048225 biolink:CellularComponent suberin network An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier. go.json http://purl.obolibrary.org/obo/GO_0048225 GO:0000283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000283 GO:0000282 biolink:BiologicalProcess cellular bud site selection The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae. go.json bud site selection/establishment of cell polarity http://purl.obolibrary.org/obo/GO_0000282 GO:0048224 biolink:CellularComponent lignin network An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens. go.json http://purl.obolibrary.org/obo/GO_0048224 GO:0000281 biolink:BiologicalProcess mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. go.json cytokinesis after mitosis http://purl.obolibrary.org/obo/GO_0000281 goslim_pombe GO:0048223 biolink:CellularComponent hemicellulose network Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan. go.json http://purl.obolibrary.org/obo/GO_0048223 GO:0000299 biolink:CellularComponent obsolete integral to membrane of membrane fraction OBSOLETE. Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes. go.json integral to membrane of membrane fraction True http://purl.obolibrary.org/obo/GO_0000299 GO:0048233 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048233 GO:0000298 biolink:MolecularActivity endopolyphosphatase activity Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. EC:3.6.1.10|MetaCyc:ENDOPOLYPHOSPHATASE-RXN|RHEA:22452 go.json metaphosphatase activity|polymetaphosphatase activity|polyphosphatase activity|polyphosphate depolymerase activity|polyphosphate polyphosphohydrolase activity http://purl.obolibrary.org/obo/GO_0000298 GO:0048232 biolink:BiologicalProcess male gamete generation Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. go.json http://purl.obolibrary.org/obo/GO_0048232 GO:0000297 biolink:MolecularActivity spermine transmembrane transporter activity Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. go.json http://purl.obolibrary.org/obo/GO_0000297 GO:0048231 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048231 GO:0000296 biolink:BiologicalProcess spermine transport The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0000296 GO:0048230 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048230 GO:0000291 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. go.json exonucleolytic degradation of mRNA|mRNA breakdown, exonucleolytic|mRNA degradation, exonucleolytic|nuclear mRNA catabolic process, exonucleolytic http://purl.obolibrary.org/obo/GO_0000291 GO:0000290 biolink:BiologicalProcess deadenylation-dependent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. go.json deadenylation-dependent decapping of nuclear mRNA|deadenylylation-dependent decapping http://purl.obolibrary.org/obo/GO_0000290 GO:0048239 biolink:BiologicalProcess negative regulation of DNA recombination at telomere Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere. go.json down regulation of telomeric recombination at telomere|down-regulation of telomeric recombination at telomere|downregulation of telomeric recombination at telomere|inhibition of telomeric recombination at telomere|negative regulation of telomeric recombination at telomere|suppression of telomeric recombination at telomere http://purl.obolibrary.org/obo/GO_0048239 GO:0048238 biolink:CellularComponent smooth endoplasmic reticulum lumen The volume enclosed by the membranes of the smooth endoplasmic reticulum. NIF_Subcellular:sao927884761 go.json SER lumen|smooth ER lumen http://purl.obolibrary.org/obo/GO_0048238 GO:0048237 biolink:CellularComponent rough endoplasmic reticulum lumen The volume enclosed by the membranes of the rough endoplasmic reticulum. NIF_Subcellular:sao1819509473 go.json RER lumen|rough ER lumen http://purl.obolibrary.org/obo/GO_0048237 GO:0000295 biolink:MolecularActivity adenine nucleotide transmembrane transporter activity Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other. Reactome:R-HSA-389652 go.json http://purl.obolibrary.org/obo/GO_0000295 GO:0000294 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, RNase MRP-dependent A minor MRP-dependent nuclear-transcribed mRNA degradation pathway that begins with an endonucleolytic cleavage to generate unprotected ends. go.json nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay http://purl.obolibrary.org/obo/GO_0000294 GO:0048236 biolink:BiologicalProcess plant-type sporogenesis The formation of plant spores derived from the products of meiosis. The spore gives rise to gametophytes. go.json plant spore formation http://purl.obolibrary.org/obo/GO_0048236 GO:0048235 biolink:BiologicalProcess pollen sperm cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte. go.json male gamete generation|male gametophyte sperm cell differentiation|sperm cell differentiation http://purl.obolibrary.org/obo/GO_0048235 GO:0000293 biolink:MolecularActivity ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. go.json ferric chelate reductase activity|iron chelate reductase activity http://purl.obolibrary.org/obo/GO_0000293 GO:0000292 biolink:BiologicalProcess RNA fragment catabolic process The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing. go.json RNA fragment breakdown|RNA fragment catabolism|RNA fragment degradation|group I intron catabolic process http://purl.obolibrary.org/obo/GO_0000292 GO:0048234 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048234 GO:0048244 biolink:MolecularActivity phytanoyl-CoA dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate. EC:1.14.11.18|KEGG_REACTION:R05722|MetaCyc:1.14.11.18-RXN|RHEA:16065|Reactome:R-HSA-389639 go.json phytanoyl-CoA 2 oxoglutarate dioxygenase activity|phytanoyl-CoA 2-hydroxylase activity|phytanoyl-CoA alpha-hydroxylase activity|phytanoyl-CoA hydroxylase activity|phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) http://purl.obolibrary.org/obo/GO_0048244 GO:0000266 biolink:BiologicalProcess mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. go.json mitochondrial division|mitochondrial proliferation http://purl.obolibrary.org/obo/GO_0000266 GO:0048243 biolink:BiologicalProcess norepinephrine secretion The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. go.json noradrenaline secretion http://purl.obolibrary.org/obo/GO_0048243 GO:0000265 biolink:MolecularActivity obsolete heterotrimeric G-protein GTPase, gamma-subunit OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit. go.json heterotrimeric G-protein GTPase, gamma-subunit True http://purl.obolibrary.org/obo/GO_0000265 GO:0048242 biolink:BiologicalProcess epinephrine secretion The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system. go.json adrenaline secretion http://purl.obolibrary.org/obo/GO_0048242 GO:0000264 biolink:MolecularActivity obsolete heterotrimeric G-protein GTPase, beta-subunit OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit. go.json heterotrimeric G-protein GTPase, beta-subunit True http://purl.obolibrary.org/obo/GO_0000264 GO:0000263 biolink:MolecularActivity obsolete heterotrimeric G-protein GTPase, alpha-subunit OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity. go.json heterotrimeric G-protein GTPase, alpha-subunit True http://purl.obolibrary.org/obo/GO_0000263 GO:0048241 biolink:BiologicalProcess epinephrine transport The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json adrenaline transport http://purl.obolibrary.org/obo/GO_0048241 GO:1903409 biolink:BiologicalProcess reactive oxygen species biosynthetic process The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. go.json ROS formation|ROS generation|reactive oxygen species anabolism|reactive oxygen species biosynthesis|reactive oxygen species formation|reactive oxygen species generation|reactive oxygen species synthesis http://purl.obolibrary.org/obo/GO_1903409 GO:0048240 biolink:BiologicalProcess sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. go.json sperm activation http://purl.obolibrary.org/obo/GO_0048240 GO:1903408 biolink:BiologicalProcess positive regulation of P-type sodium:potassium-exchanging transporter activity Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. go.json activation of (Na+ + K+)-ATPase activity|activation of (Na+ + K+)-activated ATPase activity|activation of ATP phosphohydrolase (Na+/K+-exchanging)|activation of Na(+)/K(+)-ATPase activity|activation of Na(+)/K(+)-exchanging ATPase activity|activation of Na+,K+ pump|activation of Na+,K+-ATPase activity|activation of Na+/K+-ATPase activity|activation of Na+/K+-exchanging ATPase activity|activation of Na,K-activated ATPase activity|activation of Na,K-pump|activation of sodium/potassium-exchanging ATPase activity|activation of sodium/potassium-transporting ATPase activity|activation of sodium:potassium exchanging ATPase activity|activation of sodium:potassium-exchanging ATPase activity|positive regulation of (Na+ + K+)-ATPase activity|positive regulation of (Na+ + K+)-activated ATPase activity|positive regulation of ATP phosphohydrolase (Na+/K+-exchanging)|positive regulation of Na(+)/K(+)-ATPase activity|positive regulation of Na(+)/K(+)-exchanging ATPase activity|positive regulation of Na+,K+ pump|positive regulation of Na+,K+-ATPase activity|positive regulation of Na+/K+-ATPase activity|positive regulation of Na+/K+-exchanging ATPase activity|positive regulation of Na,K-activated ATPase activity|positive regulation of Na,K-pump|positive regulation of sodium/potassium-exchanging ATPase activity|positive regulation of sodium/potassium-transporting ATPase activity|positive regulation of sodium:potassium exchanging ATPase activity|positive regulation of sodium:potassium-exchanging ATPase activity|up regulation of (Na+ + K+)-ATPase activity|up regulation of (Na+ + K+)-activated ATPase activity|up regulation of ATP phosphohydrolase (Na+/K+-exchanging)|up regulation of Na(+)/K(+)-ATPase activity|up regulation of Na(+)/K(+)-exchanging ATPase activity|up regulation of Na+,K+ pump|up regulation of Na+,K+-ATPase activity|up regulation of Na+/K+-ATPase activity|up regulation of Na+/K+-exchanging ATPase activity|up regulation of Na,K-activated ATPase activity|up regulation of Na,K-pump|up regulation of sodium/potassium-exchanging ATPase activity|up regulation of sodium/potassium-transporting ATPase activity|up regulation of sodium:potassium exchanging ATPase activity|up regulation of sodium:potassium-exchanging ATPase activity|up-regulation of (Na+ + K+)-ATPase activity|up-regulation of (Na+ + K+)-activated ATPase activity|up-regulation of ATP phosphohydrolase (Na+/K+-exchanging)|up-regulation of Na(+)/K(+)-ATPase activity|up-regulation of Na(+)/K(+)-exchanging ATPase activity|up-regulation of Na+,K+ pump|up-regulation of Na+,K+-ATPase activity|up-regulation of Na+/K+-ATPase activity|up-regulation of Na+/K+-exchanging ATPase activity|up-regulation of Na,K-activated ATPase activity|up-regulation of Na,K-pump|up-regulation of sodium/potassium-exchanging ATPase activity|up-regulation of sodium/potassium-transporting ATPase activity|up-regulation of sodium:potassium exchanging ATPase activity|up-regulation of sodium:potassium-exchanging ATPase activity|upregulation of (Na+ + K+)-ATPase activity|upregulation of (Na+ + K+)-activated ATPase activity|upregulation of ATP phosphohydrolase (Na+/K+-exchanging)|upregulation of Na(+)/K(+)-ATPase activity|upregulation of Na(+)/K(+)-exchanging ATPase activity|upregulation of Na+,K+ pump|upregulation of Na+,K+-ATPase activity|upregulation of Na+/K+-ATPase activity|upregulation of Na+/K+-exchanging ATPase activity|upregulation of Na,K-activated ATPase activity|upregulation of Na,K-pump|upregulation of sodium/potassium-exchanging ATPase activity|upregulation of sodium/potassium-transporting ATPase activity|upregulation of sodium:potassium exchanging ATPase activity|upregulation of sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_1903408 gocheck_do_not_annotate GO:0000269 biolink:MolecularActivity toxin export channel activity Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. go.json http://purl.obolibrary.org/obo/GO_0000269 GO:0000268 biolink:MolecularActivity peroxisome targeting sequence binding Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome. go.json PTS binding|PTS receptor|peroxisome targeting signal receptor http://purl.obolibrary.org/obo/GO_0000268 GO:1903407 biolink:BiologicalProcess negative regulation of P-type sodium:potassium-exchanging transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. go.json down regulation of (Na+ + K+)-ATPase activity|down regulation of (Na+ + K+)-activated ATPase activity|down regulation of ATP phosphohydrolase (Na+/K+-exchanging)|down regulation of Na(+)/K(+)-ATPase activity|down regulation of Na(+)/K(+)-exchanging ATPase activity|down regulation of Na+,K+ pump|down regulation of Na+,K+-ATPase activity|down regulation of Na+/K+-ATPase activity|down regulation of Na+/K+-exchanging ATPase activity|down regulation of Na,K-activated ATPase activity|down regulation of Na,K-pump|down regulation of sodium/potassium-exchanging ATPase activity|down regulation of sodium/potassium-transporting ATPase activity|down regulation of sodium:potassium exchanging ATPase activity|down regulation of sodium:potassium-exchanging ATPase activity|down-regulation of (Na+ + K+)-ATPase activity|down-regulation of (Na+ + K+)-activated ATPase activity|down-regulation of ATP phosphohydrolase (Na+/K+-exchanging)|down-regulation of Na(+)/K(+)-ATPase activity|down-regulation of Na(+)/K(+)-exchanging ATPase activity|down-regulation of Na+,K+ pump|down-regulation of Na+,K+-ATPase activity|down-regulation of Na+/K+-ATPase activity|down-regulation of Na+/K+-exchanging ATPase activity|down-regulation of Na,K-activated ATPase activity|down-regulation of Na,K-pump|down-regulation of sodium/potassium-exchanging ATPase activity|down-regulation of sodium/potassium-transporting ATPase activity|down-regulation of sodium:potassium exchanging ATPase activity|down-regulation of sodium:potassium-exchanging ATPase activity|downregulation of (Na+ + K+)-ATPase activity|downregulation of (Na+ + K+)-activated ATPase activity|downregulation of ATP phosphohydrolase (Na+/K+-exchanging)|downregulation of Na(+)/K(+)-ATPase activity|downregulation of Na(+)/K(+)-exchanging ATPase activity|downregulation of Na+,K+ pump|downregulation of Na+,K+-ATPase activity|downregulation of Na+/K+-ATPase activity|downregulation of Na+/K+-exchanging ATPase activity|downregulation of Na,K-activated ATPase activity|downregulation of Na,K-pump|downregulation of sodium/potassium-exchanging ATPase activity|downregulation of sodium/potassium-transporting ATPase activity|downregulation of sodium:potassium exchanging ATPase activity|downregulation of sodium:potassium-exchanging ATPase activity|inhibition of (Na+ + K+)-ATPase activity|inhibition of (Na+ + K+)-activated ATPase activity|inhibition of ATP phosphohydrolase (Na+/K+-exchanging)|inhibition of Na(+)/K(+)-ATPase activity|inhibition of Na(+)/K(+)-exchanging ATPase activity|inhibition of Na+,K+ pump|inhibition of Na+,K+-ATPase activity|inhibition of Na+/K+-ATPase activity|inhibition of Na+/K+-exchanging ATPase activity|inhibition of Na,K-activated ATPase activity|inhibition of Na,K-pump|inhibition of sodium/potassium-exchanging ATPase activity|inhibition of sodium/potassium-transporting ATPase activity|inhibition of sodium:potassium exchanging ATPase activity|inhibition of sodium:potassium-exchanging ATPase activity|negative regulation of (Na+ + K+)-ATPase activity|negative regulation of (Na+ + K+)-activated ATPase activity|negative regulation of ATP phosphohydrolase (Na+/K+-exchanging)|negative regulation of Na(+)/K(+)-ATPase activity|negative regulation of Na(+)/K(+)-exchanging ATPase activity|negative regulation of Na+,K+ pump|negative regulation of Na+,K+-ATPase activity|negative regulation of Na+/K+-ATPase activity|negative regulation of Na+/K+-exchanging ATPase activity|negative regulation of Na,K-activated ATPase activity|negative regulation of Na,K-pump|negative regulation of sodium/potassium-exchanging ATPase activity|negative regulation of sodium/potassium-transporting ATPase activity|negative regulation of sodium:potassium exchanging ATPase activity|negative regulation of sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_1903407 gocheck_do_not_annotate GO:1903406 biolink:BiologicalProcess regulation of P-type sodium:potassium-exchanging transporter activity Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. go.json regulation of (Na+ + K+)-ATPase activity|regulation of (Na+ + K+)-activated ATPase activity|regulation of ATP phosphohydrolase (Na+/K+-exchanging)|regulation of Na(+)/K(+)-ATPase activity|regulation of Na(+)/K(+)-exchanging ATPase activity|regulation of Na+,K+ pump|regulation of Na+,K+-ATPase activity|regulation of Na+/K+-ATPase activity|regulation of Na+/K+-exchanging ATPase activity|regulation of Na,K-activated ATPase activity|regulation of Na,K-pump|regulation of sodium pump|regulation of sodium/potassium-exchanging ATPase activity|regulation of sodium/potassium-transporting ATPase activity|regulation of sodium:potassium exchanging ATPase activity|regulation of sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_1903406 gocheck_do_not_annotate GO:0000267 biolink:CellularComponent obsolete cell fraction OBSOLETE. A generic term for parts of cells prepared by disruptive biochemical techniques. go.json cell fraction True http://purl.obolibrary.org/obo/GO_0000267 GO:1903405 biolink:BiologicalProcess protein localization to nuclear body A process in which a protein is transported to, or maintained in, a location within a nuclear body. go.json protein localisation in nuclear body|protein localisation to nuclear body|protein localization in nuclear body http://purl.obolibrary.org/obo/GO_1903405 GO:1903404 biolink:BiologicalProcess positive regulation of renal phosphate excretion Any process that activates or increases the frequency, rate or extent of renal phosphate excretion. go.json activation of renal phosphate excretion|activation of renal phosphate ion excretion|positive regulation of renal phosphate ion excretion|up regulation of renal phosphate excretion|up regulation of renal phosphate ion excretion|up-regulation of renal phosphate excretion|up-regulation of renal phosphate ion excretion|upregulation of renal phosphate excretion|upregulation of renal phosphate ion excretion http://purl.obolibrary.org/obo/GO_1903404 GO:1903403 biolink:BiologicalProcess negative regulation of renal phosphate excretion Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion. go.json down regulation of renal phosphate excretion|down regulation of renal phosphate ion excretion|down-regulation of renal phosphate excretion|down-regulation of renal phosphate ion excretion|downregulation of renal phosphate excretion|downregulation of renal phosphate ion excretion|inhibition of renal phosphate excretion|inhibition of renal phosphate ion excretion|negative regulation of renal phosphate ion excretion http://purl.obolibrary.org/obo/GO_1903403 GO:1903402 biolink:BiologicalProcess regulation of renal phosphate excretion Any process that modulates the frequency, rate or extent of renal phosphate excretion. go.json regulation of renal phosphate ion excretion http://purl.obolibrary.org/obo/GO_1903402 GO:0048249 biolink:MolecularActivity high-affinity phosphate transmembrane transporter activity Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity phosphate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0048249 GO:1903401 biolink:BiologicalProcess L-lysine transmembrane transport The directed movement of L-lysine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903401 GO:0048248 biolink:MolecularActivity CXCR3 chemokine receptor binding Binding to a CXCR3 chemokine receptor. go.json http://purl.obolibrary.org/obo/GO_0048248 GO:0000262 biolink:CellularComponent mitochondrial chromosome A chromosome found in the mitochondrion of a eukaryotic cell. NIF_Subcellular:sao1186327184 go.json mitochondrial DNA|mitochondrial genome|mtDNA http://purl.obolibrary.org/obo/GO_0000262 GO:0048247 biolink:BiologicalProcess lymphocyte chemotaxis The directed movement of a lymphocyte in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0048247 GO:0000261 biolink:MolecularActivity obsolete sodium-translocating V-type ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria. go.json sodium-translocating V-type ATPase activity True http://purl.obolibrary.org/obo/GO_0000261 GO:1903400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903400 GO:0048246 biolink:BiologicalProcess macrophage chemotaxis The movement of a macrophage in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0048246 GO:0000260 biolink:MolecularActivity obsolete hydrogen-translocating V-type ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria. go.json hydrogen-translocating V-type ATPase activity True http://purl.obolibrary.org/obo/GO_0000260 GO:0048245 biolink:BiologicalProcess eosinophil chemotaxis The movement of an eosinophil in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0048245 GO:0000277 biolink:MolecularActivity [cytochrome c]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c. EC:2.1.1.59|MetaCyc:2.1.1.59-RXN|RHEA:24312 go.json S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity|S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity|cytochrome c (lysine) methyltransferase activity|cytochrome c methyltransferase activity|cytochrome c-lysine N-methyltransferase activity|cytochrome c-specific protein methylase III activity|cytochrome c-specific protein-lysine methyltransferase activity http://purl.obolibrary.org/obo/GO_0000277 GO:0048255 biolink:BiologicalProcess mRNA stabilization Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. go.json http://purl.obolibrary.org/obo/GO_0048255 GO:0048254 biolink:BiologicalProcess snoRNA localization Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. go.json establishment and maintenance of snoRNA localization|small nucleolar RNA localization|snoRNA localisation http://purl.obolibrary.org/obo/GO_0048254 GO:0000276 biolink:CellularComponent mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. go.json http://purl.obolibrary.org/obo/GO_0000276 GO:0000275 biolink:CellularComponent mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. go.json hydrogen-transporting ATP synthase, F1 sector|proton-transporting ATP synthase complex, catalytic core F(1) http://purl.obolibrary.org/obo/GO_0000275 GO:0048253 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048253 GO:0048252 biolink:BiologicalProcess lauric acid metabolic process The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources. go.json lauric acid metabolism|n-dodecanoic acid metabolic process|n-dodecanoic acid metabolism http://purl.obolibrary.org/obo/GO_0048252 GO:0000274 biolink:CellularComponent mitochondrial proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. go.json mitochondrial proton-transporting ATP synthase, peripheral stalk http://purl.obolibrary.org/obo/GO_0000274 GO:0048251 biolink:BiologicalProcess elastic fiber assembly Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. go.json elastic fibre assembly|elastin fiber assembly|elastin fibre assembly http://purl.obolibrary.org/obo/GO_0048251 GO:1903419 biolink:BiologicalProcess protein localization to cortical endoplasmic reticulum A process in which a protein is transported to, or maintained in, a location within a cortical endoplasmic reticulum. go.json protein localisation in cortical endoplasmic reticulum|protein localisation to cortical endoplasmic reticulum|protein localization in cortical endoplasmic reticulum|protein localization to cortical ER http://purl.obolibrary.org/obo/GO_1903419 GO:0048250 biolink:BiologicalProcess iron import into the mitochondrion The process in which iron is transported from the cytosol into the mitochondrial matrix. go.json mitochondrial iron cation transmembrane transport|mitochondrial iron ion transmembrane transport|mitochondrial iron ion transport|mitochondrial iron transport http://purl.obolibrary.org/obo/GO_0048250 GO:1903418 biolink:BiologicalProcess protein localization to plasma membrane of cell tip A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip. go.json protein localisation in plasma membrane of cell tip|protein localisation to plasma membrane of cell tip|protein localization in plasma membrane of cell tip http://purl.obolibrary.org/obo/GO_1903418 GO:0000279 biolink:BiologicalProcess M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. Wikipedia:M_phase go.json M-phase http://purl.obolibrary.org/obo/GO_0000279 gocheck_do_not_annotate GO:0000278 biolink:BiologicalProcess mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. Wikipedia:Mitosis go.json mitosis http://purl.obolibrary.org/obo/GO_0000278 goslim_chembl|goslim_drosophila|goslim_generic|goslim_yeast GO:1903416 biolink:BiologicalProcess response to glycoside Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus. go.json cellular response to ouabain http://purl.obolibrary.org/obo/GO_1903416 GO:1903415 biolink:BiologicalProcess flavonoid transport from endoplasmic reticulum to plant-type vacuole The directed movement of flavonoid from endoplasmic reticulum to plant-type vacuole. go.json flavonoid accumulation in vacuole http://purl.obolibrary.org/obo/GO_1903415 GO:1903414 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903414 GO:1903413 biolink:BiologicalProcess cellular response to bile acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1903413 GO:0048259 biolink:BiologicalProcess regulation of receptor-mediated endocytosis Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. go.json regulation of receptor mediated endocytosis http://purl.obolibrary.org/obo/GO_0048259 GO:1903412 biolink:BiologicalProcess response to bile acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1903412 GO:0000273 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000273 GO:0000272 biolink:BiologicalProcess polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json multicellular organismal polysaccharide catabolic process|polysaccharide breakdown|polysaccharide catabolism|polysaccharide degradation http://purl.obolibrary.org/obo/GO_0000272 GO:0048258 biolink:MolecularActivity 3-ketoglucose-reductase activity Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose. MetaCyc:KETOGLUCOSE-REDUCTASE-RXN go.json http://purl.obolibrary.org/obo/GO_0048258 GO:1903411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903411 GO:0000271 biolink:BiologicalProcess polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. go.json glycan biosynthesis|glycan biosynthetic process|polysaccharide anabolism|polysaccharide biosynthesis|polysaccharide formation|polysaccharide synthesis http://purl.obolibrary.org/obo/GO_0000271 GO:0048257 biolink:MolecularActivity 3'-flap endonuclease activity Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. go.json 3' flap endonuclease activity http://purl.obolibrary.org/obo/GO_0048257 GO:1903410 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903410 GO:0048256 biolink:MolecularActivity flap endonuclease activity Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. go.json http://purl.obolibrary.org/obo/GO_0048256 GO:0000270 biolink:BiologicalProcess peptidoglycan metabolic process The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network. go.json murein metabolic process|murein metabolism|peptidoglycan metabolism http://purl.obolibrary.org/obo/GO_0000270 GO:0048266 biolink:BiologicalProcess behavioral response to pain Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. go.json behavioural response to pain http://purl.obolibrary.org/obo/GO_0048266 GO:0000244 biolink:BiologicalProcess spliceosomal tri-snRNP complex assembly The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. go.json assembly of spliceosomal tri-snRNP|assembly of spliceosomal tri-snRNP U4/U6.U5|assembly of spliceosomal tri-snRNP U4atac/U6atac.U5|snRNP recycling|spliceosomal tri-snRNP U4/U6.U5 assembly|spliceosomal tri-snRNP U4atac/U6atac.U5 assembly|spliceosomal tri-snRNP assembly http://purl.obolibrary.org/obo/GO_0000244 GO:0000243 biolink:CellularComponent commitment complex A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. go.json mammalian spliceosomal E complex|mammalian spliceosomal complex E|yeast spliceosomal complex CC http://purl.obolibrary.org/obo/GO_0000243 GO:0048265 biolink:BiologicalProcess response to pain Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. go.json physiological response to pain http://purl.obolibrary.org/obo/GO_0048265 GO:0048264 biolink:BiologicalProcess determination of ventral identity The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json determination of abaxial identity http://purl.obolibrary.org/obo/GO_0048264 GO:0000242 biolink:CellularComponent pericentriolar material A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. go.json http://purl.obolibrary.org/obo/GO_0000242 GO:0000241 biolink:BiologicalProcess diakinesis The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred. Wikipedia:Diakinesis|Wikipedia:Meiosis#Diakinesis go.json http://purl.obolibrary.org/obo/GO_0000241 gocheck_do_not_annotate GO:0048263 biolink:BiologicalProcess determination of dorsal identity Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json determination of adaxial identity http://purl.obolibrary.org/obo/GO_0048263 GO:0000248 biolink:MolecularActivity C-5 sterol desaturase activity Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. Reactome:R-HSA-195664|Reactome:R-HSA-6807053 go.json sterol-C5-desaturase activity http://purl.obolibrary.org/obo/GO_0000248 GO:0048262 biolink:BiologicalProcess determination of dorsal/ventral asymmetry Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis. go.json determination of adaxial/abaxial asymmetry|determination of dorsal-ventral asymmetry|determination of dorsoventral asymmetry http://purl.obolibrary.org/obo/GO_0048262 GO:0048261 biolink:BiologicalProcess negative regulation of receptor-mediated endocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. go.json down regulation of receptor mediated endocytosis|down-regulation of receptor mediated endocytosis|downregulation of receptor mediated endocytosis|inhibition of receptor mediated endocytosis|negative regulation of receptor mediated endocytosis http://purl.obolibrary.org/obo/GO_0048261 GO:0000247 biolink:MolecularActivity C-8 sterol isomerase activity Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. go.json delta-8-delta-7 sterol isomerase activity http://purl.obolibrary.org/obo/GO_0000247 GO:1903429 biolink:BiologicalProcess regulation of cell maturation Any process that modulates the frequency, rate or extent of cell maturation. go.json regulation of functional differentiation http://purl.obolibrary.org/obo/GO_1903429 GO:0000246 biolink:MolecularActivity delta24(24-1) sterol reductase activity Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH. EC:1.3.1.71|KEGG_REACTION:R05641|MetaCyc:1.3.1.71-RXN|RHEA:18501 go.json C-24(28) sterol reductase activity|D24(24-1)-sterol reductase activity|delta24(241)-sterol reductase activity|ergosterol:NADP+ delta24(241)-oxidoreductase activity|sterol Delta(24(28))-methylene reductase activity|sterol Delta(24(28))-reductase activity|sterol delta-24(28) methylene reductase activity|sterol delta-24(28) reductase activity|sterol delta24(28)-methylene reductase activity|sterol delta24(28)-reductase activity http://purl.obolibrary.org/obo/GO_0000246 GO:0048260 biolink:BiologicalProcess positive regulation of receptor-mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. go.json activation of receptor mediated endocytosis|positive regulation of receptor mediated endocytosis|stimulation of receptor mediated endocytosis|up regulation of receptor mediated endocytosis|up-regulation of receptor mediated endocytosis|upregulation of receptor mediated endocytosis http://purl.obolibrary.org/obo/GO_0048260 GO:1903428 biolink:BiologicalProcess positive regulation of reactive oxygen species biosynthetic process Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. go.json activation of ROS formation|activation of ROS generation|activation of reactive oxygen species anabolism|activation of reactive oxygen species biosynthesis|activation of reactive oxygen species biosynthetic process|activation of reactive oxygen species formation|activation of reactive oxygen species generation|activation of reactive oxygen species synthesis|positive regulation of ROS formation|positive regulation of ROS generation|positive regulation of reactive oxygen species anabolism|positive regulation of reactive oxygen species biosynthesis|positive regulation of reactive oxygen species formation|positive regulation of reactive oxygen species generation|positive regulation of reactive oxygen species synthesis|up regulation of ROS formation|up regulation of ROS generation|up regulation of reactive oxygen species anabolism|up regulation of reactive oxygen species biosynthesis|up regulation of reactive oxygen species biosynthetic process|up regulation of reactive oxygen species formation|up regulation of reactive oxygen species generation|up regulation of reactive oxygen species synthesis|up-regulation of ROS formation|up-regulation of ROS generation|up-regulation of reactive oxygen species anabolism|up-regulation of reactive oxygen species biosynthesis|up-regulation of reactive oxygen species biosynthetic process|up-regulation of reactive oxygen species formation|up-regulation of reactive oxygen species generation|up-regulation of reactive oxygen species synthesis|upregulation of ROS formation|upregulation of ROS generation|upregulation of reactive oxygen species anabolism|upregulation of reactive oxygen species biosynthesis|upregulation of reactive oxygen species biosynthetic process|upregulation of reactive oxygen species formation|upregulation of reactive oxygen species generation|upregulation of reactive oxygen species synthesis http://purl.obolibrary.org/obo/GO_1903428 GO:0000245 biolink:BiologicalProcess spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. go.json spliceosome assembly http://purl.obolibrary.org/obo/GO_0000245 GO:1903427 biolink:BiologicalProcess negative regulation of reactive oxygen species biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. go.json down regulation of ROS formation|down regulation of ROS generation|down regulation of reactive oxygen species anabolism|down regulation of reactive oxygen species biosynthesis|down regulation of reactive oxygen species biosynthetic process|down regulation of reactive oxygen species formation|down regulation of reactive oxygen species generation|down regulation of reactive oxygen species synthesis|down-regulation of ROS formation|down-regulation of ROS generation|down-regulation of reactive oxygen species anabolism|down-regulation of reactive oxygen species biosynthesis|down-regulation of reactive oxygen species biosynthetic process|down-regulation of reactive oxygen species formation|down-regulation of reactive oxygen species generation|down-regulation of reactive oxygen species synthesis|downregulation of ROS formation|downregulation of ROS generation|downregulation of reactive oxygen species anabolism|downregulation of reactive oxygen species biosynthesis|downregulation of reactive oxygen species biosynthetic process|downregulation of reactive oxygen species formation|downregulation of reactive oxygen species generation|downregulation of reactive oxygen species synthesis|inhibition of ROS formation|inhibition of ROS generation|inhibition of reactive oxygen species anabolism|inhibition of reactive oxygen species biosynthesis|inhibition of reactive oxygen species biosynthetic process|inhibition of reactive oxygen species formation|inhibition of reactive oxygen species generation|inhibition of reactive oxygen species synthesis|negative regulation of ROS formation|negative regulation of ROS generation|negative regulation of reactive oxygen species anabolism|negative regulation of reactive oxygen species biosynthesis|negative regulation of reactive oxygen species formation|negative regulation of reactive oxygen species generation|negative regulation of reactive oxygen species synthesis|prevention of ROS generation http://purl.obolibrary.org/obo/GO_1903427 GO:1903426 biolink:BiologicalProcess regulation of reactive oxygen species biosynthetic process Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. go.json regulation of ROS formation|regulation of ROS generation|regulation of reactive oxygen species anabolism|regulation of reactive oxygen species biosynthesis|regulation of reactive oxygen species formation|regulation of reactive oxygen species generation|regulation of reactive oxygen species synthesis http://purl.obolibrary.org/obo/GO_1903426 GO:1903425 biolink:MolecularActivity fluoride transmembrane transporter activity Enables the transfer of fluoride from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_1903425 GO:1903424 biolink:BiologicalProcess fluoride transmembrane transport The process in which fluoride is transported across a membrane. go.json fluoride membrane transport|transmembrane fluoride transport http://purl.obolibrary.org/obo/GO_1903424 GO:0000240 biolink:BiologicalProcess diplotene The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. Wikipedia:Diplotene|Wikipedia:Meiosis#Diplotene go.json http://purl.obolibrary.org/obo/GO_0000240 gocheck_do_not_annotate GO:1903423 biolink:BiologicalProcess positive regulation of synaptic vesicle recycling Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling. go.json activation of kiss-and-run synaptic vesicle recycling|activation of kiss-and-stay synaptic vesicle recycling|activation of synaptic vesicle recycling|positive regulation of kiss-and-run synaptic vesicle recycling|positive regulation of kiss-and-stay synaptic vesicle recycling|up regulation of kiss-and-run synaptic vesicle recycling|up regulation of kiss-and-stay synaptic vesicle recycling|up regulation of synaptic vesicle recycling|up-regulation of kiss-and-run synaptic vesicle recycling|up-regulation of kiss-and-stay synaptic vesicle recycling|up-regulation of synaptic vesicle recycling|upregulation of kiss-and-run synaptic vesicle recycling|upregulation of kiss-and-stay synaptic vesicle recycling|upregulation of synaptic vesicle recycling http://purl.obolibrary.org/obo/GO_1903423 GO:1903422 biolink:BiologicalProcess negative regulation of synaptic vesicle recycling Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling. go.json down regulation of kiss-and-run synaptic vesicle recycling|down regulation of kiss-and-stay synaptic vesicle recycling|down regulation of synaptic vesicle recycling|down-regulation of kiss-and-run synaptic vesicle recycling|down-regulation of kiss-and-stay synaptic vesicle recycling|down-regulation of synaptic vesicle recycling|downregulation of kiss-and-run synaptic vesicle recycling|downregulation of kiss-and-stay synaptic vesicle recycling|downregulation of synaptic vesicle recycling|inhibition of kiss-and-run synaptic vesicle recycling|inhibition of kiss-and-stay synaptic vesicle recycling|inhibition of synaptic vesicle recycling|negative regulation of kiss-and-run synaptic vesicle recycling|negative regulation of kiss-and-stay synaptic vesicle recycling http://purl.obolibrary.org/obo/GO_1903422 GO:0048269 biolink:CellularComponent methionine adenosyltransferase complex A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules. go.json MAT complex http://purl.obolibrary.org/obo/GO_0048269 GO:1903421 biolink:BiologicalProcess regulation of synaptic vesicle recycling Any process that modulates the frequency, rate or extent of synaptic vesicle recycling. go.json regulation of kiss-and-run synaptic vesicle recycling|regulation of kiss-and-stay synaptic vesicle recycling http://purl.obolibrary.org/obo/GO_1903421 GO:0048268 biolink:BiologicalProcess clathrin coat assembly The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. go.json clathrin cage assembly http://purl.obolibrary.org/obo/GO_0048268 GO:1903420 biolink:BiologicalProcess protein localization to endoplasmic reticulum tubular network A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network. go.json protein localisation in endoplasmic reticulum tubular network|protein localisation to endoplasmic reticulum tubular network|protein localization in endoplasmic reticulum tubular network|protein localization to tubular ER http://purl.obolibrary.org/obo/GO_1903420 GO:0048267 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048267 GO:0014885 biolink:BiologicalProcess detection of injury involved in regulation of muscle adaptation The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. go.json detection of injury involved in regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014885 GO:1903430 biolink:BiologicalProcess negative regulation of cell maturation Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. go.json down regulation of cell maturation|down regulation of functional differentiation|down-regulation of cell maturation|down-regulation of functional differentiation|downregulation of cell maturation|downregulation of functional differentiation|inhibition of cell maturation|inhibition of functional differentiation|negative regulation of functional differentiation http://purl.obolibrary.org/obo/GO_1903430 GO:0014884 biolink:BiologicalProcess detection of muscle inactivity involved in regulation of muscle adaptation The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. go.json http://purl.obolibrary.org/obo/GO_0014884 GO:0014883 biolink:BiologicalProcess transition between fast and slow fiber The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. go.json transition between fast and slow fibre|transition fast-slow fiber|transition fast-slow fibre http://purl.obolibrary.org/obo/GO_0014883 GO:0014882 biolink:BiologicalProcess regulation of myofibril number Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. go.json change of myofibril number http://purl.obolibrary.org/obo/GO_0014882 GO:0014889 biolink:BiologicalProcess muscle atrophy A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. Wikipedia:Muscle_atrophy go.json http://purl.obolibrary.org/obo/GO_0014889 GO:0014888 biolink:BiologicalProcess striated muscle adaptation Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. go.json striated muscle plasticity http://purl.obolibrary.org/obo/GO_0014888 GO:0014887 biolink:BiologicalProcess cardiac muscle adaptation The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. go.json cardiac muscle plasticity http://purl.obolibrary.org/obo/GO_0014887 GO:0014886 biolink:BiologicalProcess transition between slow and fast fiber The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. go.json transition between slow and fast fibre|transition slow-fast fiber|transition slow-fast fibre http://purl.obolibrary.org/obo/GO_0014886 GO:0000249 biolink:MolecularActivity C-22 sterol desaturase activity Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. go.json http://purl.obolibrary.org/obo/GO_0000249 GO:0014881 biolink:BiologicalProcess regulation of myofibril size Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. go.json change of myofibril size http://purl.obolibrary.org/obo/GO_0014881 GO:0014880 biolink:BiologicalProcess regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014880 GO:0097200 biolink:MolecularActivity cysteine-type endopeptidase activity involved in execution phase of apoptosis Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. go.json effector caspase activity|executioner caspase activity http://purl.obolibrary.org/obo/GO_0097200 GO:0000255 biolink:BiologicalProcess allantoin metabolic process The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. go.json allantoin metabolism http://purl.obolibrary.org/obo/GO_0000255 GO:0048277 biolink:BiologicalProcess obsolete nonexocytotic vesicle docking OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process. go.json non-exocytotic vesicle docking|nonexocytotic vesicle docking True http://purl.obolibrary.org/obo/GO_0048277 GO:0000254 biolink:MolecularActivity C-4 methylsterol oxidase activity Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O. EC:1.14.18.9|MetaCyc:RXN-13188|RHEA:55220|Reactome:R-HSA-194641|Reactome:R-HSA-194669 go.json 4-methylsterol oxidase activity|methylsterol hydroxylase activity|methylsterol monooxygenase activity http://purl.obolibrary.org/obo/GO_0000254 GO:0048276 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048276 GO:0097202 biolink:BiologicalProcess activation of cysteine-type endopeptidase activity Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. go.json activation of caspase activity|activation of metacaspase activity http://purl.obolibrary.org/obo/GO_0097202 gocheck_do_not_annotate GO:0000253 biolink:MolecularActivity 3-keto sterol reductase activity Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+. EC:1.1.1.270|MetaCyc:RXN-13686|RHEA:34787|Reactome:R-HSA-194632|Reactome:R-HSA-194689 go.json 3-KSR activity|3-keto-steroid reductase activity|3beta-hydroxy-steroid:NADP+ 3-oxidoreductase http://purl.obolibrary.org/obo/GO_0000253 GO:0048275 biolink:BiologicalProcess N-terminal peptidyl-arginine acetylation The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase. RESID:AA0354 go.json http://purl.obolibrary.org/obo/GO_0048275 gocheck_do_not_annotate GO:0000252 biolink:MolecularActivity C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. EC:1.1.1.170|Reactome:R-HSA-194642|Reactome:R-HSA-194718 go.json 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)|3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)|3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)|3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity|C-3 sterol dehydrogenase (C-4 decarboxylase) activity|C-3 sterol dehydrogenase activity|sterol 4alpha-carboxylic decarboxylase activity|sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity|sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) http://purl.obolibrary.org/obo/GO_0000252 GO:0097201 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter in response to stress Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0097201 GO:0048274 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048274 GO:0048273 biolink:MolecularActivity mitogen-activated protein kinase p38 binding Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. go.json MAPK p38 binding http://purl.obolibrary.org/obo/GO_0048273 GO:0000259 biolink:MolecularActivity obsolete intracellular nucleoside transmembrane transporter activity OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell. go.json intracellular nucleoside transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_0000259 GO:0048272 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048272 GO:0000258 biolink:MolecularActivity obsolete isoleucine/valine:sodium symporter activity OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in). go.json isoleucine/valine:sodium symporter activity True http://purl.obolibrary.org/obo/GO_0000258 GO:0000257 biolink:MolecularActivity nitrilase activity Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. EC:3.5.5.1|KEGG_REACTION:R00540|MetaCyc:3.5.5.1-RXN|RHEA:21724|UM-BBD_enzymeID:e0283 go.json acetonitrilase activity|benzonitrilase activity|nitrile aminohydrolase activity http://purl.obolibrary.org/obo/GO_0000257 GO:0048271 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048271 GO:0000256 biolink:BiologicalProcess allantoin catabolic process The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. go.json allantoin breakdown|allantoin catabolism|allantoin degradation http://purl.obolibrary.org/obo/GO_0000256 GO:1903439 biolink:CellularComponent calcitonin family receptor complex A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far. go.json http://purl.obolibrary.org/obo/GO_1903439 GO:0048270 biolink:MolecularActivity methionine adenosyltransferase regulator activity Binds to and modulates the activity of methionine adenosyltransferase. go.json MAT regulator activity http://purl.obolibrary.org/obo/GO_0048270 GO:1903438 biolink:BiologicalProcess positive regulation of mitotic cytokinetic process Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process. go.json activation of mitotic cytokinetic process|up regulation of mitotic cytokinetic process|up-regulation of mitotic cytokinetic process|upregulation of mitotic cytokinetic process http://purl.obolibrary.org/obo/GO_1903438 GO:1903437 biolink:BiologicalProcess negative regulation of mitotic cytokinetic process Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process. go.json down regulation of mitotic cytokinetic process|down-regulation of mitotic cytokinetic process|downregulation of mitotic cytokinetic process|inhibition of mitotic cytokinetic process http://purl.obolibrary.org/obo/GO_1903437 GO:1903436 biolink:BiologicalProcess regulation of mitotic cytokinetic process Any process that modulates the frequency, rate or extent of mitotic cytokinetic process. go.json http://purl.obolibrary.org/obo/GO_1903436 GO:1903435 biolink:BiologicalProcess positive regulation of constitutive secretory pathway Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway. go.json activation of constitutive secretory pathway|up regulation of constitutive secretory pathway|up-regulation of constitutive secretory pathway|upregulation of constitutive secretory pathway http://purl.obolibrary.org/obo/GO_1903435 GO:1903434 biolink:BiologicalProcess negative regulation of constitutive secretory pathway Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway. go.json down regulation of constitutive secretory pathway|down-regulation of constitutive secretory pathway|downregulation of constitutive secretory pathway|inhibition of constitutive secretory pathway http://purl.obolibrary.org/obo/GO_1903434 GO:0000251 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000251 GO:0000250 biolink:MolecularActivity lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. EC:5.4.99.7|KEGG_REACTION:R03199|MetaCyc:LANOSTEROL-SYNTHASE-RXN|RHEA:14621|Reactome:R-HSA-191366 go.json (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)|2,3-epoxysqualene lanosterol cyclase activity|2,3-epoxysqualene--lanosterol cyclase activity|2,3-epoxysqualene-lanosterol cyclase activity|2,3-oxidosqualene sterol cyclase activity|2,3-oxidosqualene-lanosterol cyclase activity|OSC|lanosterol 2,3-oxidosqualene cyclase activity|oxidosqualene--lanosterol cyclase activity|oxidosqualene-lanosterol cyclase activity|oxidosqualene:lanosterol cyclase activity|squalene 2,3-epoxide:lanosterol cyclase activity|squalene epoxidase-cyclase activity|squalene-2,3-oxide-lanosterol cyclase activity http://purl.obolibrary.org/obo/GO_0000250 GO:1903433 biolink:BiologicalProcess regulation of constitutive secretory pathway Any process that modulates the frequency, rate or extent of constitutive secretory pathway. go.json http://purl.obolibrary.org/obo/GO_1903433 GO:0048279 biolink:BiologicalProcess vesicle fusion with endoplasmic reticulum The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum. go.json vesicle fusion with ER http://purl.obolibrary.org/obo/GO_0048279 GO:1903432 biolink:BiologicalProcess regulation of TORC1 signaling Any process that modulates the frequency, rate or extent of TORC1 signaling. go.json regulation of TORC1 signal transduction http://purl.obolibrary.org/obo/GO_1903432 GO:1903431 biolink:BiologicalProcess positive regulation of cell maturation Any process that activates or increases the frequency, rate or extent of cell maturation. go.json activation of cell maturation|activation of functional differentiation|positive regulation of functional differentiation|up regulation of cell maturation|up regulation of functional differentiation|up-regulation of cell maturation|up-regulation of functional differentiation|upregulation of cell maturation|upregulation of functional differentiation http://purl.obolibrary.org/obo/GO_1903431 GO:0048278 biolink:BiologicalProcess vesicle docking The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. go.json vesicle to membrane docking http://purl.obolibrary.org/obo/GO_0048278 GO:0014896 biolink:BiologicalProcess muscle hypertrophy The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. Wikipedia:Muscle_hypertrophy go.json http://purl.obolibrary.org/obo/GO_0014896 GO:1903441 biolink:BiologicalProcess protein localization to ciliary membrane A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. go.json protein localisation in ciliary membrane|protein localisation to ciliary membrane|protein localization in ciliary membrane http://purl.obolibrary.org/obo/GO_1903441 GO:1903440 biolink:CellularComponent amylin receptor complex A protein complex which is capable of amylin receptor activity. go.json http://purl.obolibrary.org/obo/GO_1903440 GO:0014895 biolink:BiologicalProcess smooth muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. go.json http://purl.obolibrary.org/obo/GO_0014895 GO:0014894 biolink:BiologicalProcess response to denervation involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. go.json http://purl.obolibrary.org/obo/GO_0014894 GO:0014893 biolink:BiologicalProcess response to rest involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation. go.json http://purl.obolibrary.org/obo/GO_0014893 GO:0014899 biolink:BiologicalProcess cardiac muscle atrophy A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation. go.json http://purl.obolibrary.org/obo/GO_0014899 GO:0014898 biolink:BiologicalProcess cardiac muscle hypertrophy in response to stress The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. go.json http://purl.obolibrary.org/obo/GO_0014898 GO:0014897 biolink:BiologicalProcess striated muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. go.json http://purl.obolibrary.org/obo/GO_0014897 GO:0097208 biolink:CellularComponent alveolar lamellar body A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. go.json http://purl.obolibrary.org/obo/GO_0097208 GO:0048280 biolink:BiologicalProcess vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. go.json http://purl.obolibrary.org/obo/GO_0048280 GO:0097207 biolink:BiologicalProcess bud dormancy process A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud. go.json bud dormancy http://purl.obolibrary.org/obo/GO_0097207 GO:0097209 biolink:CellularComponent epidermal lamellar body A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. go.json http://purl.obolibrary.org/obo/GO_0097209 GO:0097204 biolink:CellularComponent phagocytic cup base The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking. go.json http://purl.obolibrary.org/obo/GO_0097204 GO:0014891 biolink:BiologicalProcess striated muscle atrophy A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. go.json http://purl.obolibrary.org/obo/GO_0014891 GO:0097203 biolink:CellularComponent phagocytic cup lip The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome. go.json http://purl.obolibrary.org/obo/GO_0097203 GO:0097206 biolink:BiologicalProcess nephrocyte filtration The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm. go.json http://purl.obolibrary.org/obo/GO_0097206 GO:0014890 biolink:BiologicalProcess smooth muscle atrophy A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. go.json http://purl.obolibrary.org/obo/GO_0014890 GO:0097205 biolink:BiologicalProcess renal filtration A renal system process in which fluid circulating through the body is filtered through a barrier system. go.json http://purl.obolibrary.org/obo/GO_0097205 GO:0048288 biolink:BiologicalProcess nuclear membrane fusion involved in karyogamy The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. go.json nuclear membrane fusion during karyogamy http://purl.obolibrary.org/obo/GO_0048288 GO:0000222 biolink:CellularComponent plasma membrane proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane. go.json plasma membrane hydrogen ion-transporting ATPase V0 domain http://purl.obolibrary.org/obo/GO_0000222 GO:0000221 biolink:CellularComponent vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. go.json vacuolar hydrogen ion-transporting ATPase V1 domain http://purl.obolibrary.org/obo/GO_0000221 GO:0048287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048287 GO:0000220 biolink:CellularComponent vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. go.json vacuolar hydrogen ion-transporting ATPase V0 domain http://purl.obolibrary.org/obo/GO_0000220 GO:0048286 biolink:BiologicalProcess lung alveolus development The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. go.json alveolarization|alveologenesis http://purl.obolibrary.org/obo/GO_0048286 GO:0048285 biolink:BiologicalProcess organelle fission The creation of two or more organelles by division of one organelle. go.json http://purl.obolibrary.org/obo/GO_0048285 goslim_pir|goslim_yeast GO:0048284 biolink:BiologicalProcess organelle fusion The creation of a single organelle from two or more organelles. go.json http://purl.obolibrary.org/obo/GO_0048284 goslim_pir|goslim_yeast GO:0000226 biolink:BiologicalProcess microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. go.json microtubule cytoskeleton organisation|microtubule cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0000226 goslim_pombe GO:0000225 biolink:MolecularActivity N-acetylglucosaminylphosphatidylinositol deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. EC:3.5.1.89|MetaCyc:3.1.1.69-RXN|RHEA:11660|Reactome:R-HSA-162857 go.json 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity|GlcNAc-PI de-N-acetylase activity|GlcNAc-PI deacetylase activity|N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity|N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity|acetylglucosaminylphosphatidylinositol deacetylase activity http://purl.obolibrary.org/obo/GO_0000225 GO:0048283 biolink:BiologicalProcess indeterminate inflorescence morphogenesis The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems. go.json http://purl.obolibrary.org/obo/GO_0048283 GO:0000224 biolink:MolecularActivity peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. EC:3.5.1.52|MetaCyc:3.5.1.52-RXN|Reactome:R-HSA-8850594 go.json N-glycanase activity|N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity|N-oligosaccharide glycopeptidase activity|PNGase|PNGase A|PNGase F|glycopeptidase activity|glycopeptide N-glycosidase activity|jack-bean glycopeptidase|peptide:N-glycanase http://purl.obolibrary.org/obo/GO_0000224 GO:0048282 biolink:BiologicalProcess determinate inflorescence morphogenesis The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems. go.json http://purl.obolibrary.org/obo/GO_0048282 GO:0000223 biolink:CellularComponent plasma membrane proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane. go.json plasma membrane hydrogen ion-transporting ATPase V1 domain http://purl.obolibrary.org/obo/GO_0000223 GO:0048281 biolink:BiologicalProcess inflorescence morphogenesis The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers. go.json http://purl.obolibrary.org/obo/GO_0048281 GO:1903449 biolink:BiologicalProcess androst-4-ene-3,17-dione biosynthetic process The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione. go.json androst-4-ene-3,17-dione anabolism|androst-4-ene-3,17-dione biosynthesis|androst-4-ene-3,17-dione formation|androst-4-ene-3,17-dione synthesis|androstenedione biosynthetic process http://purl.obolibrary.org/obo/GO_1903449 GO:1903448 biolink:BiologicalProcess geraniol biosynthetic process The chemical reactions and pathways resulting in the formation of geraniol. go.json geraniol anabolism|geraniol biosynthesis|geraniol formation|geraniol synthesis http://purl.obolibrary.org/obo/GO_1903448 GO:0014869 biolink:BiologicalProcess detection of muscle inactivity The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0014869 GO:1903447 biolink:BiologicalProcess geraniol catabolic process The chemical reactions and pathways resulting in the breakdown of geraniol. go.json geraniol breakdown|geraniol catabolism|geraniol degradation http://purl.obolibrary.org/obo/GO_1903447 GO:1903446 biolink:BiologicalProcess geraniol metabolic process The chemical reactions and pathways involving geraniol. go.json geraniol metabolism http://purl.obolibrary.org/obo/GO_1903446 GO:0014868 biolink:BiologicalProcess cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014868 GO:1903445 biolink:BiologicalProcess protein transport from ciliary membrane to plasma membrane The directed movement of protein from ciliary membrane to plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1903445 GO:1903444 biolink:BiologicalProcess negative regulation of brown fat cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation. go.json down regulation of brown adipocyte cell differentiation|down regulation of brown adipocyte differentiation|down regulation of brown fat cell differentiation|down-regulation of brown adipocyte cell differentiation|down-regulation of brown adipocyte differentiation|down-regulation of brown fat cell differentiation|downregulation of brown adipocyte cell differentiation|downregulation of brown adipocyte differentiation|downregulation of brown fat cell differentiation|inhibition of brown adipocyte cell differentiation|inhibition of brown adipocyte differentiation|inhibition of brown fat cell differentiation|negative regulation of brown adipocyte cell differentiation|negative regulation of brown adipocyte differentiation http://purl.obolibrary.org/obo/GO_1903444 GO:1903443 biolink:BiologicalProcess cellular response to lipoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1903443 GO:0048289 biolink:BiologicalProcess isotype switching to IgE isotypes The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus. go.json class switch recombination to IgE isotypes|class switching to IgE isotypes|isotype switch recombination to IgE isotypes http://purl.obolibrary.org/obo/GO_0048289 GO:1903442 biolink:BiologicalProcess response to lipoic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1903442 GO:1903452 biolink:BiologicalProcess positive regulation of G1 to G0 transition Any process that activates or increases the frequency, rate or extent of G1 to G0 transition. go.json activation of G1 to G0 transition|activation of G1/G0 transition|activation of cell cycle quiescence|activation of establishment of cell quiescence|activation of stationary phase|positive regulation of G1/G0 transition|positive regulation of cell cycle quiescence|positive regulation of establishment of cell quiescence|positive regulation of stationary phase|up regulation of G1 to G0 transition|up regulation of G1/G0 transition|up regulation of cell cycle quiescence|up regulation of establishment of cell quiescence|up regulation of stationary phase|up-regulation of G1 to G0 transition|up-regulation of G1/G0 transition|up-regulation of cell cycle quiescence|up-regulation of establishment of cell quiescence|up-regulation of stationary phase|upregulation of G1 to G0 transition|upregulation of G1/G0 transition|upregulation of cell cycle quiescence|upregulation of establishment of cell quiescence|upregulation of stationary phase http://purl.obolibrary.org/obo/GO_1903452 GO:0014863 biolink:BiologicalProcess detection of inactivity The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0014863 GO:0014862 biolink:BiologicalProcess regulation of skeletal muscle contraction by chemo-mechanical energy conversion Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres. go.json http://purl.obolibrary.org/obo/GO_0014862 GO:1903451 biolink:BiologicalProcess negative regulation of G1 to G0 transition Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition. go.json down regulation of G1 to G0 transition|down regulation of G1/G0 transition|down regulation of cell cycle quiescence|down regulation of establishment of cell quiescence|down regulation of stationary phase|down-regulation of G1 to G0 transition|down-regulation of G1/G0 transition|down-regulation of cell cycle quiescence|down-regulation of establishment of cell quiescence|down-regulation of stationary phase|downregulation of G1 to G0 transition|downregulation of G1/G0 transition|downregulation of cell cycle quiescence|downregulation of establishment of cell quiescence|downregulation of stationary phase|inhibition of G1 to G0 transition|inhibition of G1/G0 transition|inhibition of cell cycle quiescence|inhibition of establishment of cell quiescence|inhibition of stationary phase|negative regulation of G1/G0 transition|negative regulation of cell cycle quiescence|negative regulation of establishment of cell quiescence|negative regulation of stationary phase http://purl.obolibrary.org/obo/GO_1903451 GO:0014861 biolink:BiologicalProcess regulation of skeletal muscle contraction via regulation of action potential Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. go.json regulation of skeletal muscle contraction via membrane action potential http://purl.obolibrary.org/obo/GO_0014861 GO:1903450 biolink:BiologicalProcess regulation of G1 to G0 transition Any process that modulates the frequency, rate or extent of G1 to G0 transition. go.json regulation of G1/G0 transition|regulation of cell cycle quiescence|regulation of establishment of cell quiescence|regulation of stationary phase http://purl.obolibrary.org/obo/GO_1903450 GO:0014860 biolink:BiologicalProcess neurotransmitter secretion involved in regulation of skeletal muscle contraction The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. go.json neurotransmitter secretion involved in control of skeletal muscle contraction http://purl.obolibrary.org/obo/GO_0014860 GO:0014866 biolink:BiologicalProcess skeletal myofibril assembly The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. go.json http://purl.obolibrary.org/obo/GO_0014866 GO:0014865 biolink:BiologicalProcess detection of activity The series of events in which an activity stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0014865 GO:0014864 biolink:BiologicalProcess detection of muscle activity The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0014864 GO:0048291 biolink:BiologicalProcess isotype switching to IgG isotypes The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. go.json class switching to IgG isotypes|isotype switch recombination to IgG isotypes http://purl.obolibrary.org/obo/GO_0048291 GO:0000229 biolink:CellularComponent obsolete cytoplasmic chromosome OBSOLETE. A chromosome found in the cytoplasm. go.json cytoplasmic interphase chromosome True http://purl.obolibrary.org/obo/GO_0000229 GO:0048290 biolink:BiologicalProcess isotype switching to IgA isotypes The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus. go.json class switching to IgA isotypes|isotype switch recombination to IgA isotypes http://purl.obolibrary.org/obo/GO_0048290 GO:0000228 biolink:CellularComponent nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. go.json nuclear interphase chromosome http://purl.obolibrary.org/obo/GO_0000228 goslim_chembl|goslim_generic GO:0000227 biolink:MolecularActivity oxaloacetate secondary active transmembrane transporter activity Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json oxaloacetate carrier activity http://purl.obolibrary.org/obo/GO_0000227 GO:0048299 biolink:BiologicalProcess regulation of isotype switching to IgD isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes. go.json regulation of class switch recombination to IgD isotypes|regulation of class switching to IgD isotypes|regulation of isotype switch recombination to IgD isotypes http://purl.obolibrary.org/obo/GO_0048299 GO:0000233 biolink:CellularComponent obsolete cytoplasmic interphase chromosome OBSOLETE. A chromosome found in the cytoplasm during interphase. go.json cytoplasmic interphase chromosome True http://purl.obolibrary.org/obo/GO_0000233 GO:0048298 biolink:BiologicalProcess positive regulation of isotype switching to IgA isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes. go.json activation of isotype switching to IgA isotypes|positive regulation of class switch recombination to IgA isotypes|positive regulation of class switching to IgA isotypes|positive regulation of isotype switch recombination to IgA isotypes|stimulation of isotype switching to IgA isotypes|up regulation of isotype switching to IgA isotypes|up-regulation of isotype switching to IgA isotypes|upregulation of isotype switching to IgA isotypes http://purl.obolibrary.org/obo/GO_0048298 GO:0000232 biolink:CellularComponent obsolete nuclear interphase chromosome OBSOLETE. A chromosome found in the nucleus during interphase. go.json nuclear interphase chromosome True http://purl.obolibrary.org/obo/GO_0000232 GO:0000231 biolink:CellularComponent obsolete cytoplasmic mitotic chromosome OBSOLETE. A chromosome found in the cytoplasm during mitosis. go.json cytoplasmic mitotic chromosome True http://purl.obolibrary.org/obo/GO_0000231 GO:0048297 biolink:BiologicalProcess negative regulation of isotype switching to IgA isotypes Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes. go.json down regulation of isotype switching to IgA isotypes|down-regulation of isotype switching to IgA isotypes|downregulation of isotype switching to IgA isotypes|inhibition of isotype switching to IgA isotypes|negative regulation of class switch recombination to IgA isotypes|negative regulation of class switching to IgA isotypes|negative regulation of isotype switch recombination to IgA isotypes http://purl.obolibrary.org/obo/GO_0048297 GO:0048296 biolink:BiologicalProcess regulation of isotype switching to IgA isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes. go.json regulation of class switch recombination to IgA isotypes|regulation of class switching to IgA isotypes|regulation of isotype switch recombination to IgA isotypes http://purl.obolibrary.org/obo/GO_0048296 GO:0000230 biolink:CellularComponent obsolete nuclear mitotic chromosome OBSOLETE. A chromosome found in the nucleus during mitosis. go.json nuclear mitotic chromosome True http://purl.obolibrary.org/obo/GO_0000230 GO:0048295 biolink:BiologicalProcess positive regulation of isotype switching to IgE isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes. go.json activation of isotype switching to IgE isotypes|positive regulation of class switch recombination to IgE isotypes|positive regulation of class switching to IgE isotypes|positive regulation of isotype switch recombination to IgE isotypes|stimulation of isotype switching to IgE isotypes|up regulation of isotype switching to IgE isotypes|up-regulation of isotype switching to IgE isotypes|upregulation of isotype switching to IgE isotypes http://purl.obolibrary.org/obo/GO_0048295 GO:0000237 biolink:BiologicalProcess leptotene The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible. Wikipedia:Leptotene|Wikipedia:Meiosis#Leptotene go.json http://purl.obolibrary.org/obo/GO_0000237 gocheck_do_not_annotate GO:0048294 biolink:BiologicalProcess negative regulation of isotype switching to IgE isotypes Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes. go.json down regulation of isotype switching to IgE isotypes|down-regulation of isotype switching to IgE isotypes|downregulation of isotype switching to IgE isotypes|inhibition of isotype switching to IgE isotypes|negative regulation of class switch recombination to IgE isotypes|negative regulation of class switching to IgE isotypes|negative regulation of isotype switch recombination to IgE isotypes http://purl.obolibrary.org/obo/GO_0048294 GO:0000236 biolink:BiologicalProcess mitotic prometaphase The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. go.json http://purl.obolibrary.org/obo/GO_0000236 gocheck_do_not_annotate GO:0048293 biolink:BiologicalProcess regulation of isotype switching to IgE isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes. go.json regulation of class switch recombination to IgE isotypes|regulation of class switching to IgE isotypes|regulation of isotype switch recombination to IgE isotypes http://purl.obolibrary.org/obo/GO_0048293 GO:0000235 biolink:CellularComponent astral microtubule Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. go.json http://purl.obolibrary.org/obo/GO_0000235 GO:0048292 biolink:BiologicalProcess isotype switching to IgD isotypes The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus. go.json class switching to IgD isotypes|isotype switch recombination to IgD isotypes http://purl.obolibrary.org/obo/GO_0048292 GO:0000234 biolink:MolecularActivity phosphoethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. EC:2.1.1.103|KEGG_REACTION:R02037|MetaCyc:2.1.1.103-RXN|RHEA:20365 go.json S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity|phosphoethanolamine methyltransferase activity http://purl.obolibrary.org/obo/GO_0000234 GO:1903459 biolink:BiologicalProcess mitotic DNA replication lagging strand elongation Any lagging strand elongation that is involved in mitotic cell cycle DNA replication. go.json lagging strand elongation involved in DNA replication during S phase involved in mitotic cell cycle|lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle|lagging strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle|lagging strand elongation involved in mitotic DNA replication|lagging strand elongation involved in mitotic nuclear cell cycle DNA replication|lagging strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903459 GO:1903458 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903458 GO:1903457 biolink:BiologicalProcess lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate. go.json lactate breakdown|lactate catabolism|lactate degradation http://purl.obolibrary.org/obo/GO_1903457 GO:0014879 biolink:BiologicalProcess detection of electrical stimulus involved in regulation of muscle adaptation The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. go.json http://purl.obolibrary.org/obo/GO_0014879 GO:1903456 biolink:BiologicalProcess positive regulation of androst-4-ene-3,17-dione biosynthetic process Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. go.json activation of androst-4-ene-3,17-dione anabolism|activation of androst-4-ene-3,17-dione biosynthesis|activation of androst-4-ene-3,17-dione biosynthetic process|activation of androst-4-ene-3,17-dione formation|activation of androst-4-ene-3,17-dione synthesis|activation of androstenedione|positive regulation of androst-4-ene-3,17-dione anabolism|positive regulation of androst-4-ene-3,17-dione biosynthesis|positive regulation of androst-4-ene-3,17-dione formation|positive regulation of androst-4-ene-3,17-dione synthesis|positive regulation of androstenedione biosynthetic process|up regulation of androst-4-ene-3,17-dione anabolism|up regulation of androst-4-ene-3,17-dione biosynthesis|up regulation of androst-4-ene-3,17-dione biosynthetic process|up regulation of androst-4-ene-3,17-dione formation|up regulation of androst-4-ene-3,17-dione synthesis|up regulation of androstenedione biosynthetic process|up-regulation of androst-4-ene-3,17-dione anabolism|up-regulation of androst-4-ene-3,17-dione biosynthesis|up-regulation of androst-4-ene-3,17-dione biosynthetic process|up-regulation of androst-4-ene-3,17-dione formation|up-regulation of androst-4-ene-3,17-dione synthesis|up-regulation of androstenedione biosynthetic process|upregulation of androst-4-ene-3,17-dione anabolism|upregulation of androst-4-ene-3,17-dione biosynthesis|upregulation of androst-4-ene-3,17-dione biosynthetic process|upregulation of androst-4-ene-3,17-dione formation|upregulation of androst-4-ene-3,17-dione synthesis|upregulation of androstenedione biosynthetic process http://purl.obolibrary.org/obo/GO_1903456 GO:1903455 biolink:BiologicalProcess negative regulation of androst-4-ene-3,17-dione biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. go.json down regulation of androst-4-ene-3,17-dione anabolism|down regulation of androst-4-ene-3,17-dione biosynthesis|down regulation of androst-4-ene-3,17-dione biosynthetic process|down regulation of androst-4-ene-3,17-dione formation|down regulation of androst-4-ene-3,17-dione synthesis|down regulation of androstenedione biosynthetic process|down-regulation of androst-4-ene-3,17-dione anabolism|down-regulation of androst-4-ene-3,17-dione biosynthesis|down-regulation of androst-4-ene-3,17-dione biosynthetic process|down-regulation of androst-4-ene-3,17-dione formation|down-regulation of androst-4-ene-3,17-dione synthesis|down-regulation of androstenedione biosynthetic process|downregulation of androst-4-ene-3,17-dione anabolism|downregulation of androst-4-ene-3,17-dione biosynthesis|downregulation of androst-4-ene-3,17-dione biosynthetic process|downregulation of androst-4-ene-3,17-dione formation|downregulation of androst-4-ene-3,17-dione synthesis|downregulation of androstenedione biosynthetic process|inhibition of androst-4-ene-3,17-dione anabolism|inhibition of androst-4-ene-3,17-dione biosynthesis|inhibition of androst-4-ene-3,17-dione biosynthetic process|inhibition of androst-4-ene-3,17-dione formation|inhibition of androst-4-ene-3,17-dione synthesis|inhibition of androstenedione|negative regulation of androst-4-ene-3,17-dione anabolism|negative regulation of androst-4-ene-3,17-dione biosynthesis|negative regulation of androst-4-ene-3,17-dione formation|negative regulation of androst-4-ene-3,17-dione synthesis|negative regulation of androstenedione biosynthetic process http://purl.obolibrary.org/obo/GO_1903455 GO:1903454 biolink:BiologicalProcess regulation of androst-4-ene-3,17-dione biosynthetic process Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. go.json regulation of androst-4-ene-3,17-dione anabolism|regulation of androst-4-ene-3,17-dione biosynthesis|regulation of androst-4-ene-3,17-dione formation|regulation of androst-4-ene-3,17-dione synthesis|regulation of androstenedione biosynthetic process http://purl.obolibrary.org/obo/GO_1903454 GO:1903453 biolink:BiologicalProcess obsolete RNA interference involved in olfactory learning OBSOLETE. Any RNA interference that is involved in olfactory learning. go.json RNAi involved in olfactory learning|posttranscriptional gene silencing by siRNA involved in olfactory learning True http://purl.obolibrary.org/obo/GO_1903453 GO:0014874 biolink:BiologicalProcess response to stimulus involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. go.json response to stimulus involved in regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014874 GO:1903463 biolink:BiologicalProcess regulation of mitotic cell cycle DNA replication Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication. go.json regulation of DNA replication during S phase involved in mitotic cell cycle|regulation of DNA replication involved in S phase involved in mitotic cell cycle|regulation of DNA replication involved in S-phase involved in mitotic cell cycle|regulation of mitotic nuclear cell cycle DNA replication|regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903463 GO:0014873 biolink:BiologicalProcess response to muscle activity involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation. go.json response to fatigue|response to muscle activity involved in regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014873 GO:1903461 biolink:BiologicalProcess Okazaki fragment processing involved in mitotic DNA replication Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication. go.json DNA replication, Okazaki fragment processing involved in DNA replication during S phase involved in mitotic cell cycle|DNA replication, Okazaki fragment processing involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA replication, Okazaki fragment processing involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA replication, Okazaki fragment processing involved in mitotic nuclear cell cycle DNA replication|DNA replication, Okazaki fragment processing involved in nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903461 GO:0014872 biolink:BiologicalProcess myoblast division The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0014872 GO:1903460 biolink:BiologicalProcess mitotic DNA replication leading strand elongation Any leading strand elongation that is involved in mitotic cell cycle DNA replication. go.json leading strand elongation involved in DNA replication during S phase involved in mitotic cell cycle|leading strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle|leading strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle|leading strand elongation involved in mitotic DNA replication|leading strand elongation involved in mitotic nuclear cell cycle DNA replication|leading strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903460 GO:0014871 biolink:BiologicalProcess cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0014871 GO:0014878 biolink:BiologicalProcess response to electrical stimulus involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation. go.json response to electrical stimulus involved in regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014878 GO:0014877 biolink:BiologicalProcess response to muscle inactivity involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation. go.json http://purl.obolibrary.org/obo/GO_0014877 GO:0014876 biolink:BiologicalProcess response to injury involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation. go.json response to injury involved in regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0014876 GO:0014875 biolink:BiologicalProcess detection of muscle activity involved in regulation of muscle adaptation The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. go.json detection of fatigue http://purl.obolibrary.org/obo/GO_0014875 GO:0000239 biolink:BiologicalProcess pachytene The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome. Wikipedia:Meiosis#Pachytene|Wikipedia:Pachytene go.json http://purl.obolibrary.org/obo/GO_0000239 gocheck_do_not_annotate GO:0000238 biolink:BiologicalProcess zygotene The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur. Wikipedia:Meiosis#Zygotene|Wikipedia:Zygotene go.json http://purl.obolibrary.org/obo/GO_0000238 gocheck_do_not_annotate GO:0014870 biolink:BiologicalProcess response to muscle inactivity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. go.json http://purl.obolibrary.org/obo/GO_0014870 GO:0048200 biolink:BiologicalProcess Golgi transport vesicle coating The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles. go.json dictyosome transport vesicle coating http://purl.obolibrary.org/obo/GO_0048200 GO:0048208 biolink:BiologicalProcess COPII vesicle coating The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. go.json COPII coating of ER-derived vesicle|COPII vesicle coat assembly|COPII vesicle coat formation http://purl.obolibrary.org/obo/GO_0048208 GO:0048207 biolink:BiologicalProcess vesicle targeting, rough ER to cis-Golgi The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi. go.json rough ER to cis-Golgi targeting|rough endoplasmic reticulum to cis-Golgi targeting|vesicle targeting, rough endoplasmic reticulum to cis-Golgi http://purl.obolibrary.org/obo/GO_0048207 GO:0048206 biolink:BiologicalProcess vesicle targeting, cis-Golgi to rough endoplasmic reticulum The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER. go.json cis-Golgi to rough ER targeting|cis-Golgi to rough endoplasmic reticulum targeting|vesicle targeting, cis-Golgi to rough ER http://purl.obolibrary.org/obo/GO_0048206 GO:0048205 biolink:BiologicalProcess COPI coating of Golgi vesicle The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. go.json COPI coating of Golgi-derived vesicle|COPI vesicle coating http://purl.obolibrary.org/obo/GO_0048205 GO:0048204 biolink:BiologicalProcess vesicle targeting, inter-Golgi cisterna The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another. go.json inter-Golgi cisterna targeting http://purl.obolibrary.org/obo/GO_0048204 GO:0048203 biolink:BiologicalProcess vesicle targeting, trans-Golgi to endosome The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome. go.json trans-Golgi to endosome targeting http://purl.obolibrary.org/obo/GO_0048203 GO:0048202 biolink:BiologicalProcess clathrin coating of Golgi vesicle The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. go.json clathrin coating of Golgi-derived vesicle http://purl.obolibrary.org/obo/GO_0048202 GO:0048201 biolink:BiologicalProcess vesicle targeting, plasma membrane to endosome The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. go.json plasma membrane to endosome targeting http://purl.obolibrary.org/obo/GO_0048201 GO:0048209 biolink:BiologicalProcess regulation of vesicle targeting, to, from or within Golgi Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. go.json regulation of Golgi vesicle targeting http://purl.obolibrary.org/obo/GO_0048209 GO:0048211 biolink:BiologicalProcess Golgi vesicle docking The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane. go.json Golgi vesicle docking with target membrane|Golgi vesicle to membrane docking|Golgi-derived vesicle docking|dictyosome vesicle docking to target membrane http://purl.obolibrary.org/obo/GO_0048211 GO:0048210 biolink:BiologicalProcess Golgi vesicle fusion to target membrane The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. go.json Golgi-derived vesicle fusion to target membrane|dictyosome vesicle fusion to target membrane http://purl.obolibrary.org/obo/GO_0048210 GO:0048219 biolink:BiologicalProcess inter-Golgi cisterna vesicle-mediated transport The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles. go.json inter-Golgi cisterna transport http://purl.obolibrary.org/obo/GO_0048219 GO:0048218 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048218 GO:0048217 biolink:CellularComponent pectic matrix The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls. go.json http://purl.obolibrary.org/obo/GO_0048217 GO:0048216 biolink:BiologicalProcess negative regulation of Golgi vesicle fusion to target membrane Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane. go.json down regulation of Golgi vesicle fusion to target membrane|down-regulation of Golgi vesicle fusion to target membrane|downregulation of Golgi vesicle fusion to target membrane|inhibition of Golgi vesicle fusion to target membrane http://purl.obolibrary.org/obo/GO_0048216 GO:0048215 biolink:BiologicalProcess positive regulation of Golgi vesicle fusion to target membrane Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane. go.json activation of Golgi vesicle fusion to target membrane|stimulation of Golgi vesicle fusion to target membrane|up regulation of Golgi vesicle fusion to target membrane|up-regulation of Golgi vesicle fusion to target membrane|upregulation of Golgi vesicle fusion to target membrane http://purl.obolibrary.org/obo/GO_0048215 GO:0048214 biolink:BiologicalProcess regulation of Golgi vesicle fusion to target membrane Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane. go.json http://purl.obolibrary.org/obo/GO_0048214 GO:0048213 biolink:BiologicalProcess Golgi vesicle prefusion complex stabilization The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized. go.json Golgi vesicle prefusion complex assembly|Golgi-derived vesicle prefusion complex stabilization|dictyosome vesicle prefusion complex stabilisation http://purl.obolibrary.org/obo/GO_0048213 GO:0048212 biolink:BiologicalProcess Golgi vesicle uncoating The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse. go.json Golgi vesicle coat depolymerization|Golgi vesicle coat protein depolymerization|Golgi-derived vesicle uncoating|dictyosome vesicle coat depolymerization http://purl.obolibrary.org/obo/GO_0048212 GO:0097354 biolink:BiologicalProcess prenylation The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added. go.json http://purl.obolibrary.org/obo/GO_0097354 GO:0000442 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000442 GO:0097353 biolink:BiologicalProcess centrolateral pattern formation The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment. go.json mediolateral pattern formation http://purl.obolibrary.org/obo/GO_0097353 GO:0000441 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000441 GO:0097356 biolink:CellularComponent perinucleolar compartment The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC. go.json perinucleolar region http://purl.obolibrary.org/obo/GO_0097356 GO:0000440 biolink:CellularComponent core TFIIH complex portion of NEF3 complex The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). go.json SSL2-core TFIIH complex portion of NEF3 complex http://purl.obolibrary.org/obo/GO_0000440 GO:0097355 biolink:BiologicalProcess protein localization to heterochromatin Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. go.json protein localisation to heterochromatin http://purl.obolibrary.org/obo/GO_0097355 GO:0000446 biolink:CellularComponent nucleoplasmic THO complex The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits. go.json http://purl.obolibrary.org/obo/GO_0000446 GO:0097350 biolink:BiologicalProcess neutrophil clearance The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. go.json http://purl.obolibrary.org/obo/GO_0097350 GO:0000445 biolink:CellularComponent THO complex part of transcription export complex The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. go.json THO complex part of TREX complex http://purl.obolibrary.org/obo/GO_0000445 GO:0097352 biolink:BiologicalProcess autophagosome maturation Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. go.json autophagic vacuole fusion|autophagic vacuole maturation|autophagosome fusion http://purl.obolibrary.org/obo/GO_0097352 GO:0000444 biolink:CellularComponent MIS12/MIND type complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. go.json MIND complex|Mis12 complex|Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex|nuclear MIS12/MIND complex http://purl.obolibrary.org/obo/GO_0000444 GO:0097351 biolink:MolecularActivity toxin sequestering activity Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json toxin-antitoxin pair type I binding|toxin-antitoxin pair type II binding http://purl.obolibrary.org/obo/GO_0097351 GO:0000443 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000443 GO:0000449 biolink:BiologicalProcess endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000449 GO:0000448 biolink:BiologicalProcess cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json cleavage at C2|cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA) http://purl.obolibrary.org/obo/GO_0000448 GO:0000447 biolink:BiologicalProcess endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json endonucleolytic cleavage at A2 http://purl.obolibrary.org/obo/GO_0000447 GO:0097358 biolink:MolecularActivity D-leucyl-tRNA(Leu) deacylase activity Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu). go.json http://purl.obolibrary.org/obo/GO_0097358 GO:0097357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097357 GO:0097359 biolink:BiologicalProcess UDP-glucosylation The covalent attachment of a UDP-glucose residue to a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0097359 GO:0000453 biolink:BiologicalProcess obsolete enzyme-directed rRNA 2'-O-methylation OBSOLETE. The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA. go.json True http://purl.obolibrary.org/obo/GO_0000453 GO:0097365 biolink:MolecularActivity stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell. go.json stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0097365 GO:0000452 biolink:BiologicalProcess snoRNA guided rRNA 2'-O-methylation The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation. go.json snoRNA guided rRNA 2'-O-ribose methylation http://purl.obolibrary.org/obo/GO_0000452 GO:0097364 biolink:MolecularActivity stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential. go.json stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential http://purl.obolibrary.org/obo/GO_0097364 GO:0097367 biolink:MolecularActivity carbohydrate derivative binding Binding to a carbohydrate derivative. go.json http://purl.obolibrary.org/obo/GO_0097367 goslim_agr|goslim_mouse GO:0000451 biolink:BiologicalProcess rRNA 2'-O-methylation The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis. go.json http://purl.obolibrary.org/obo/GO_0000451 GO:0000450 biolink:BiologicalProcess cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species. go.json http://purl.obolibrary.org/obo/GO_0000450 GO:0097366 biolink:BiologicalProcess response to bronchodilator Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes. go.json response to bronchodilator agent|response to broncholytic agent http://purl.obolibrary.org/obo/GO_0097366 gocheck_do_not_manually_annotate GO:0097361 biolink:CellularComponent CIA complex The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. go.json cytosolic iron-sulfur protein assembly complex http://purl.obolibrary.org/obo/GO_0097361 GO:0000457 biolink:BiologicalProcess endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000457 GO:0000456 biolink:BiologicalProcess obsolete dimethylation involved in SSU-rRNA maturation OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes. go.json True http://purl.obolibrary.org/obo/GO_0000456 GO:0097360 biolink:BiologicalProcess chorionic trophoblast cell proliferation The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population. go.json http://purl.obolibrary.org/obo/GO_0097360 GO:0000455 biolink:BiologicalProcess enzyme-directed rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA. go.json http://purl.obolibrary.org/obo/GO_0000455 GO:0097363 biolink:MolecularActivity protein O-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine. EC:2.4.1.255|Reactome:R-HSA-9687828 go.json O-GlcNAc transferase|O-linked N-acetylglucosaminyltransferase|OGTase|UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase|protein O-GlcNAc transferase activity http://purl.obolibrary.org/obo/GO_0097363 GO:0097362 biolink:CellularComponent MCM8-MCM9 complex A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links. go.json http://purl.obolibrary.org/obo/GO_0097362 GO:0000454 biolink:BiologicalProcess snoRNA guided rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. go.json http://purl.obolibrary.org/obo/GO_0000454 GO:0000459 biolink:BiologicalProcess obsolete exonucleolytic trimming involved in rRNA processing OBSOLETE. Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule. go.json exonucleolytic trimming during rRNA processing True http://purl.obolibrary.org/obo/GO_0000459 GO:0000458 biolink:BiologicalProcess endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000458 GO:0097369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097369 GO:0097368 biolink:BiologicalProcess establishment of Sertoli cell barrier Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions. go.json establishment of BTB|establishment of SCB|establishment of blood-testis barrier http://purl.obolibrary.org/obo/GO_0097368 GO:0000420 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000420 GO:0097332 biolink:BiologicalProcess response to antipsychotic drug Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. go.json http://purl.obolibrary.org/obo/GO_0097332 GO:0097331 biolink:BiologicalProcess response to cytarabine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus. go.json http://purl.obolibrary.org/obo/GO_0097331 GO:0097334 biolink:BiologicalProcess response to perphenazine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. go.json http://purl.obolibrary.org/obo/GO_0097334 GO:0097333 biolink:BiologicalProcess response to olanzapine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus. go.json http://purl.obolibrary.org/obo/GO_0097333 GO:0000424 biolink:BiologicalProcess micromitophagy Degradation of a mitochondrion by microautophagy. go.json http://purl.obolibrary.org/obo/GO_0000424 GO:0000423 biolink:BiologicalProcess mitophagy The selective autophagy process in which a mitochondrion is degraded by macroautophagy. Wikipedia:Mitophagy go.json macromitophagy http://purl.obolibrary.org/obo/GO_0000423 GO:0097330 biolink:BiologicalProcess response to 5-fluoro-2'-deoxyuridine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. go.json http://purl.obolibrary.org/obo/GO_0097330 GO:0000422 biolink:BiologicalProcess autophagy of mitochondrion The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. go.json mitochondrion degradation|mitochondrion disassembly|mitophagy http://purl.obolibrary.org/obo/GO_0000422 gocheck_do_not_annotate GO:0000421 biolink:CellularComponent autophagosome membrane The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. go.json autophagic vacuole membrane http://purl.obolibrary.org/obo/GO_0000421 GO:0000428 biolink:CellularComponent DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity. go.json http://purl.obolibrary.org/obo/GO_0000428 GO:0097339 biolink:BiologicalProcess glycolate transmembrane transport The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid). go.json glycolate membrane transport http://purl.obolibrary.org/obo/GO_0097339 GO:0000427 biolink:CellularComponent plastid-encoded plastid RNA polymerase complex An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition. go.json http://purl.obolibrary.org/obo/GO_0000427 GO:0000426 biolink:BiologicalProcess micropexophagy Degradation of a peroxisome by microautophagy. go.json http://purl.obolibrary.org/obo/GO_0000426 GO:0000425 biolink:BiologicalProcess pexophagy The selective autophagy process in which a peroxisome is degraded by macroautophagy. go.json macropexophagy http://purl.obolibrary.org/obo/GO_0000425 GO:0097336 biolink:BiologicalProcess response to risperidone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus. go.json http://purl.obolibrary.org/obo/GO_0097336 GO:0097335 biolink:BiologicalProcess response to quetiapine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus. go.json http://purl.obolibrary.org/obo/GO_0097335 GO:0097338 biolink:BiologicalProcess response to clozapine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus. go.json http://purl.obolibrary.org/obo/GO_0097338 GO:0000429 biolink:BiologicalProcess carbon catabolite regulation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. go.json regulation of transcription from RNA polymerase II promoter by carbon catabolites http://purl.obolibrary.org/obo/GO_0000429 GO:0097337 biolink:BiologicalProcess response to ziprasidone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. go.json http://purl.obolibrary.org/obo/GO_0097337 GO:0097343 biolink:BiologicalProcess ripoptosome assembly The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. go.json http://purl.obolibrary.org/obo/GO_0097343 GO:0000431 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_0000431 GO:0097342 biolink:CellularComponent ripoptosome A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. go.json TNFR1 complex II|Tnfr1-CII|necrosome http://purl.obolibrary.org/obo/GO_0097342 GO:0000430 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_0000430 GO:0097345 biolink:BiologicalProcess mitochondrial outer membrane permeabilization The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. go.json MOMP|mitochondrial outer membrane permeabilization during apoptotic cell death|mitochondrion outer membrane permeabilization http://purl.obolibrary.org/obo/GO_0097345 GO:0097344 biolink:CellularComponent Rix1 complex A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes. go.json IPI complex http://purl.obolibrary.org/obo/GO_0097344 GO:0000435 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. go.json activation of transcription from RNA polymerase II promoter by galactose|stimulation of transcription from RNA polymerase II promoter by galactose|up regulation of transcription from RNA polymerase II promoter by galactose|up-regulation of transcription from RNA polymerase II promoter by galactose|upregulation of transcription from RNA polymerase II promoter by galactose http://purl.obolibrary.org/obo/GO_0000435 GO:0000434 biolink:BiologicalProcess carbon catabolite repression of transcription from RNA polymerase II promoter by galactose Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. go.json down regulation of transcription from RNA polymerase II promoter by galactose|down-regulation of transcription from RNA polymerase II promoter by galactose|downregulation of transcription from RNA polymerase II promoter by galactose|inhibition of transcription from RNA polymerase II promoter by galactose http://purl.obolibrary.org/obo/GO_0000434 GO:0097341 biolink:BiologicalProcess zymogen inhibition Any process that prevents the proteolytic processing of an inactive enzyme to an active form. go.json prevention of zymogen activation http://purl.obolibrary.org/obo/GO_0097341 GO:0000433 biolink:BiologicalProcess carbon catabolite repression of transcription from RNA polymerase II promoter by glucose A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. go.json down regulation of transcription from RNA polymerase II promoter by glucose|down-regulation of transcription from RNA polymerase II promoter by glucose|downregulation of transcription from RNA polymerase II promoter by glucose|inhibition of transcription from RNA polymerase II promoter by glucose http://purl.obolibrary.org/obo/GO_0000433 GO:0097340 biolink:BiologicalProcess inhibition of cysteine-type endopeptidase activity Any process that prevents the activation of an inactive cysteine-type endopeptidase. go.json inhibition of caspase activity|prevention of caspase activity|prevention of cysteine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_0097340 gocheck_do_not_annotate GO:0000432 biolink:BiologicalProcess positive regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. go.json activation of transcription from RNA polymerase II promoter by glucose|stimulation of transcription from RNA polymerase II promoter by glucose|up regulation of transcription from RNA polymerase II promoter by glucose|up-regulation of transcription from RNA polymerase II promoter by glucose|upregulation of transcription from RNA polymerase II promoter by glucose http://purl.obolibrary.org/obo/GO_0000432 GO:0000439 biolink:CellularComponent transcription factor TFIIH core complex The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. go.json SSL2-core TFIIH complex|core TFIIH complex http://purl.obolibrary.org/obo/GO_0000439 goslim_pir GO:0000438 biolink:CellularComponent core TFIIH complex portion of holo TFIIH complex The core TFIIH complex when it is part of the general transcription factor TFIIH. go.json SSL2-core TFIIH complex portion of holo TFIIH complex http://purl.obolibrary.org/obo/GO_0000438 GO:0000437 biolink:BiologicalProcess carbon catabolite repression of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. go.json negative regulation of transcription from RNA polymerase II promoter by carbon catabolites http://purl.obolibrary.org/obo/GO_0000437 GO:0000436 biolink:BiologicalProcess carbon catabolite activation of transcription from RNA polymerase II promoter Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of transcription from RNA polymerase II promoter by carbon catabolites http://purl.obolibrary.org/obo/GO_0000436 GO:0097347 biolink:CellularComponent TAM protein secretion complex A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane. go.json translocation and assembly module protein complex http://purl.obolibrary.org/obo/GO_0097347 GO:0097346 biolink:CellularComponent INO80-type complex A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. go.json http://purl.obolibrary.org/obo/GO_0097346 GO:0097349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097349 GO:0097348 biolink:CellularComponent host cell endocytic vesicle membrane The lipid bilayer surrounding a host cell endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0097348 GO:0097398 biolink:BiologicalProcess cellular response to interleukin-17 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. go.json cellular response to IL-17 http://purl.obolibrary.org/obo/GO_0097398 GO:0097397 biolink:BiologicalProcess cellular response to interleukin-32 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus. go.json cellular response to IL-32 http://purl.obolibrary.org/obo/GO_0097397 GO:0097399 biolink:BiologicalProcess interleukin-32-mediated signaling pathway The series of molecular signals initiated by interleukin-32 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-32-mediated signaling pathway|IL-32-mediated signalling pathway|interleukin-32-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0097399 GO:0000402 biolink:MolecularActivity crossed form four-way junction DNA binding Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands. go.json crossed form Holliday junction binding http://purl.obolibrary.org/obo/GO_0000402 GO:0097394 biolink:BiologicalProcess obsolete telomeric repeat-containing RNA transcription by RNA polymerase II OBSOLETE. The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter. go.json TERRA RNA transcription from RNA pol II promoter|telomeric RNA transcription from Pol II promoter|telomeric repeat-containing RNA transcription from RNA pol II promoter True http://purl.obolibrary.org/obo/GO_0097394 GO:0000401 biolink:MolecularActivity open form four-way junction DNA binding Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over. go.json open form Holliday junction binding http://purl.obolibrary.org/obo/GO_0000401 GO:0097393 biolink:BiologicalProcess telomeric repeat-containing RNA transcription The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome. go.json TERRA transcription http://purl.obolibrary.org/obo/GO_0097393 GO:0097396 biolink:BiologicalProcess response to interleukin-17 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. go.json response to IL-17 http://purl.obolibrary.org/obo/GO_0097396 GO:0000400 biolink:MolecularActivity four-way junction DNA binding Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. go.json Holliday junction binding|forked DNA binding http://purl.obolibrary.org/obo/GO_0000400 GO:0097395 biolink:BiologicalProcess response to interleukin-32 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus. go.json response to IL-32 http://purl.obolibrary.org/obo/GO_0097395 GO:0097390 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 12 production The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL12 production http://purl.obolibrary.org/obo/GO_0097390 gocheck_do_not_annotate GO:0097392 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 16 production The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL16 production http://purl.obolibrary.org/obo/GO_0097392 gocheck_do_not_annotate GO:0097391 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 13 production The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL13 production http://purl.obolibrary.org/obo/GO_0097391 gocheck_do_not_annotate GO:0000406 biolink:MolecularActivity double-strand/single-strand DNA junction binding Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0000406 GO:0000405 biolink:MolecularActivity bubble DNA binding Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0000405 GO:0000404 biolink:MolecularActivity heteroduplex DNA loop binding Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. go.json loop DNA binding http://purl.obolibrary.org/obo/GO_0000404 GO:0000403 biolink:MolecularActivity Y-form DNA binding Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. go.json forked DNA binding|splayed Y-form DNA binding http://purl.obolibrary.org/obo/GO_0000403 GO:0000409 biolink:BiologicalProcess regulation of transcription by galactose Any process involving galactose that modulates the frequency, rate or extent or transcription. go.json http://purl.obolibrary.org/obo/GO_0000409 GO:0000408 biolink:CellularComponent EKC/KEOPS complex A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. go.json KEOPS/EKC complex|TCTC|endopeptidase-like kinase chromatin-associated protein complex|kinase, putative endopeptidase and other proteins of small size protein complex|threonyl-carbamoly transferase complex http://purl.obolibrary.org/obo/GO_0000408 GO:0000407 biolink:CellularComponent phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. go.json PAS|perivacuolar space|pre-autophagosomal structure http://purl.obolibrary.org/obo/GO_0000407 GO:0000413 biolink:BiologicalProcess protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue. go.json protein proline isomerization http://purl.obolibrary.org/obo/GO_0000413 gocheck_do_not_annotate GO:0000412 biolink:BiologicalProcess histone peptidyl-prolyl isomerization The modification of a histone by cis-trans isomerization of a proline residue. go.json histone proline isomerization http://purl.obolibrary.org/obo/GO_0000412 gocheck_do_not_annotate GO:0000411 biolink:BiologicalProcess positive regulation of transcription by galactose Any process involving galactose that activates or increases the rate of transcription. go.json activation of transcription by galactose|stimulation of transcription by galactose|up regulation of transcription by galactose|up-regulation of transcription by galactose|upregulation of transcription by galactose http://purl.obolibrary.org/obo/GO_0000411 GO:0000410 biolink:BiologicalProcess carbon catabolite repression of transcription by galactose A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. go.json down regulation of transcription by galactose|down-regulation of transcription by galactose|downregulation of transcription by galactose|inhibition of transcription by galactose http://purl.obolibrary.org/obo/GO_0000410 GO:0000417 biolink:CellularComponent HIR complex A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p. go.json HIRA complex http://purl.obolibrary.org/obo/GO_0000417 GO:0000416 biolink:BiologicalProcess obsolete positive regulation of histone H3-K36 methylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. go.json activation of histone H3-K36 methylation|stimulation of histone H3-K36 methylation|up regulation of histone H3-K36 methylation|up-regulation of histone H3-K36 methylation|upregulation of histone H3-K36 methylation True http://purl.obolibrary.org/obo/GO_0000416 GO:0000415 biolink:BiologicalProcess obsolete negative regulation of histone H3-K36 methylation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. go.json down regulation of histone H3-K36 methylation|down-regulation of histone H3-K36 methylation|downregulation of histone H3-K36 methylation|inhibition of histone H3-K36 methylation True http://purl.obolibrary.org/obo/GO_0000415 GO:0000414 biolink:BiologicalProcess obsolete regulation of histone H3-K36 methylation OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. go.json True http://purl.obolibrary.org/obo/GO_0000414 GO:0000419 biolink:CellularComponent RNA polymerase V complex RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits. go.json DNA-directed RNA polymerase IVb complex|DNA-directed RNA polymerase V complex http://purl.obolibrary.org/obo/GO_0000419 GO:0000418 biolink:CellularComponent RNA polymerase IV complex RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex. go.json DNA-directed RNA polymerase IV complex|DNA-directed RNA polymerase IVa complex http://purl.obolibrary.org/obo/GO_0000418 GO:0097376 biolink:BiologicalProcess interneuron axon guidance The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions. go.json http://purl.obolibrary.org/obo/GO_0097376 GO:0097375 biolink:BiologicalProcess spinal sensory neuron axon guidance The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0097375 GO:0097378 biolink:BiologicalProcess dorsal spinal cord interneuron axon guidance The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord. go.json dorsal interneuron axon guidance http://purl.obolibrary.org/obo/GO_0097378 GO:0097377 biolink:BiologicalProcess spinal cord interneuron axon guidance The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0097377 GO:0097372 biolink:MolecularActivity NAD-dependent histone H3K18 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein. go.json NAD-dependent histone H3-K18 deacetylase activity|NAD-dependent histone deacetylase activity (H3-K18 specific) http://purl.obolibrary.org/obo/GO_0097372 GO:0097371 biolink:MolecularActivity MDM2/MDM4 family protein binding Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53. go.json http://purl.obolibrary.org/obo/GO_0097371 GO:0097374 biolink:BiologicalProcess sensory neuron axon guidance The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses. go.json http://purl.obolibrary.org/obo/GO_0097374 GO:0097373 biolink:CellularComponent MCM core complex A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated. go.json MCM4/6/7 complex http://purl.obolibrary.org/obo/GO_0097373 GO:0097370 biolink:BiologicalProcess protein O-GlcNAcylation via threonine The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine. go.json http://purl.obolibrary.org/obo/GO_0097370 GO:0097379 biolink:BiologicalProcess dorsal spinal cord interneuron posterior axon guidance The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. go.json dorsal interneuron caudal axon projection http://purl.obolibrary.org/obo/GO_0097379 GO:0097387 biolink:CellularComponent capitate projection Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies). go.json http://purl.obolibrary.org/obo/GO_0097387 GO:0097386 biolink:CellularComponent glial cell projection A prolongation or process extending from a glial cell. go.json glial process|glial projection http://purl.obolibrary.org/obo/GO_0097386 GO:0097389 biolink:BiologicalProcess chemokine (C-C motif) ligand 21 production The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL21 production http://purl.obolibrary.org/obo/GO_0097389 gocheck_do_not_annotate GO:0097388 biolink:BiologicalProcess chemokine (C-C motif) ligand 19 production The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL19 production|EBI1 ligand chemokine production|ELC production|MIP-3-beta production|macrophage inflammatory protein-3-beta production http://purl.obolibrary.org/obo/GO_0097388 gocheck_do_not_annotate GO:0097383 biolink:MolecularActivity dIDP phosphatase activity Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate. RHEA:35211|Reactome:R-HSA-2509793 go.json deoxyinosine-diphosphatase activity http://purl.obolibrary.org/obo/GO_0097383 GO:0097382 biolink:MolecularActivity obsolete deoxynucleoside-diphosphatase activity OBSOLETE. Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate. go.json True http://purl.obolibrary.org/obo/GO_0097382 GO:0097385 biolink:BiologicalProcess programmed necrotic cell death in response to starvation A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment). go.json necrotic cell death in response to starvation http://purl.obolibrary.org/obo/GO_0097385 GO:0097384 biolink:BiologicalProcess cellular lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells. go.json cellular lipid anabolism|cellular lipid biosynthesis|cellular lipid formation|cellular lipid synthesis http://purl.obolibrary.org/obo/GO_0097384 GO:0097381 biolink:CellularComponent photoreceptor disc membrane Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. go.json http://purl.obolibrary.org/obo/GO_0097381 GO:0097380 biolink:BiologicalProcess dorsal spinal cord interneuron anterior axon guidance The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. go.json dorsal interneuron rostral axon projection http://purl.obolibrary.org/obo/GO_0097380 GO:0048343 biolink:BiologicalProcess paraxial mesodermal cell fate commitment The process in which a cell becomes committed to become a paraxial mesoderm cell. go.json http://purl.obolibrary.org/obo/GO_0048343 GO:0048342 biolink:BiologicalProcess paraxial mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell. go.json http://purl.obolibrary.org/obo/GO_0048342 GO:0048341 biolink:BiologicalProcess paraxial mesoderm formation The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048341 GO:0048340 biolink:BiologicalProcess paraxial mesoderm morphogenesis The process in which the anatomical structures of the paraxial mesoderm are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048340 GO:1903749 biolink:BiologicalProcess positive regulation of establishment of protein localization to mitochondrion Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion. go.json activation of establishment of protein localisation to mitochondrion|activation of establishment of protein localization in mitochondrion|activation of establishment of protein localization to mitochondrion|positive regulation of establishment of protein localisation to mitochondrion|positive regulation of establishment of protein localization in mitochondrion|up regulation of establishment of protein localisation to mitochondrion|up regulation of establishment of protein localization in mitochondrion|up regulation of establishment of protein localization to mitochondrion|up-regulation of establishment of protein localisation to mitochondrion|up-regulation of establishment of protein localization in mitochondrion|up-regulation of establishment of protein localization to mitochondrion|upregulation of establishment of protein localisation to mitochondrion|upregulation of establishment of protein localization in mitochondrion|upregulation of establishment of protein localization to mitochondrion http://purl.obolibrary.org/obo/GO_1903749 GO:1903748 biolink:BiologicalProcess negative regulation of establishment of protein localization to mitochondrion Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion. go.json down regulation of establishment of protein localisation to mitochondrion|down regulation of establishment of protein localization in mitochondrion|down regulation of establishment of protein localization to mitochondrion|down-regulation of establishment of protein localisation to mitochondrion|down-regulation of establishment of protein localization in mitochondrion|down-regulation of establishment of protein localization to mitochondrion|downregulation of establishment of protein localisation to mitochondrion|downregulation of establishment of protein localization in mitochondrion|downregulation of establishment of protein localization to mitochondrion|inhibition of establishment of protein localisation to mitochondrion|inhibition of establishment of protein localization in mitochondrion|inhibition of establishment of protein localization to mitochondrion|negative regulation of establishment of protein localisation to mitochondrion|negative regulation of establishment of protein localization in mitochondrion http://purl.obolibrary.org/obo/GO_1903748 GO:1903747 biolink:BiologicalProcess regulation of establishment of protein localization to mitochondrion Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. go.json regulation of establishment of protein localisation to mitochondrion|regulation of establishment of protein localization in mitochondrion http://purl.obolibrary.org/obo/GO_1903747 GO:1903746 biolink:BiologicalProcess positive regulation of nematode pharyngeal pumping Any process that activates or increases the frequency, rate or extent of nematode pharyngeal pumping. go.json activation of pharyngeal pumping|activation of pumping behavior|positive regulation of pumping behavior|up regulation of pharyngeal pumping|up regulation of pumping behavior|up-regulation of pharyngeal pumping|up-regulation of pumping behavior|upregulation of pharyngeal pumping|upregulation of pumping behavior http://purl.obolibrary.org/obo/GO_1903746 GO:1903745 biolink:BiologicalProcess negative regulation of nematode pharyngeal pumping Any process that stops, prevents or reduces the frequency, rate or extent of nematode pharyngeal pumping. go.json down regulation of pharyngeal pumping|down regulation of pumping behavior|down-regulation of pharyngeal pumping|down-regulation of pumping behavior|downregulation of pharyngeal pumping|downregulation of pumping behavior|inhibition of pharyngeal pumping|inhibition of pumping behavior|negative regulation of pumping behavior http://purl.obolibrary.org/obo/GO_1903745 GO:1903744 biolink:BiologicalProcess positive regulation of anterograde synaptic vesicle transport Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport. go.json activation of anterograde synaptic vesicle transport|up regulation of anterograde synaptic vesicle transport|up-regulation of anterograde synaptic vesicle transport|upregulation of anterograde synaptic vesicle transport http://purl.obolibrary.org/obo/GO_1903744 GO:0048349 biolink:BiologicalProcess regulation of paraxial mesodermal cell fate specification Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification. go.json http://purl.obolibrary.org/obo/GO_0048349 GO:1903743 biolink:BiologicalProcess negative regulation of anterograde synaptic vesicle transport Any process that stops, prevents or reduces the frequency, rate or extent of anterograde synaptic vesicle transport. go.json down regulation of anterograde synaptic vesicle transport|down-regulation of anterograde synaptic vesicle transport|downregulation of anterograde synaptic vesicle transport|inhibition of anterograde synaptic vesicle transport http://purl.obolibrary.org/obo/GO_1903743 GO:0048348 biolink:BiologicalProcess paraxial mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0048348 GO:1903742 biolink:BiologicalProcess regulation of anterograde synaptic vesicle transport Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport. go.json http://purl.obolibrary.org/obo/GO_1903742 goslim_synapse GO:0048347 biolink:BiologicalProcess negative regulation of paraxial mesodermal cell fate determination Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination. go.json down regulation of paraxial mesodermal cell fate determination|down-regulation of paraxial mesodermal cell fate determination|downregulation of paraxial mesodermal cell fate determination|inhibition of paraxial mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048347 GO:1903741 biolink:BiologicalProcess negative regulation of phosphatidate phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity. go.json down regulation of 3-sn-phosphatidate phosphohydrolase activity|down regulation of acid phosphatidyl phosphatase activity|down regulation of phosphatic acid phosphatase activity|down regulation of phosphatic acid phosphohydrolase activity|down regulation of phosphatidate phosphatase activity|down regulation of phosphatidate phosphohydrolase activity|down regulation of phosphatidic acid phosphatase activity|down-regulation of 3-sn-phosphatidate phosphohydrolase activity|down-regulation of acid phosphatidyl phosphatase activity|down-regulation of phosphatic acid phosphatase activity|down-regulation of phosphatic acid phosphohydrolase activity|down-regulation of phosphatidate phosphatase activity|down-regulation of phosphatidate phosphohydrolase activity|down-regulation of phosphatidic acid phosphatase activity|downregulation of 3-sn-phosphatidate phosphohydrolase activity|downregulation of acid phosphatidyl phosphatase activity|downregulation of phosphatic acid phosphatase activity|downregulation of phosphatic acid phosphohydrolase activity|downregulation of phosphatidate phosphatase activity|downregulation of phosphatidate phosphohydrolase activity|downregulation of phosphatidic acid phosphatase activity|inhibition of 3-sn-phosphatidate phosphohydrolase activity|inhibition of acid phosphatidyl phosphatase activity|inhibition of phosphatic acid phosphatase activity|inhibition of phosphatic acid phosphohydrolase activity|inhibition of phosphatidate phosphatase activity|inhibition of phosphatidate phosphohydrolase activity|inhibition of phosphatidic acid phosphatase activity|negative regulation of 3-sn-phosphatidate phosphohydrolase activity|negative regulation of acid phosphatidyl phosphatase activity|negative regulation of phosphatic acid phosphatase activity|negative regulation of phosphatic acid phosphohydrolase activity|negative regulation of phosphatidate phosphohydrolase activity|negative regulation of phosphatidic acid phosphatase activity http://purl.obolibrary.org/obo/GO_1903741 gocheck_do_not_annotate GO:0048346 biolink:BiologicalProcess positive regulation of paraxial mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination. go.json activation of paraxial mesodermal cell fate determination|stimulation of paraxial mesodermal cell fate determination|up regulation of paraxial mesodermal cell fate determination|up-regulation of paraxial mesodermal cell fate determination|upregulation of paraxial mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048346 GO:1903740 biolink:BiologicalProcess positive regulation of phosphatidate phosphatase activity Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity. go.json activation of 3-sn-phosphatidate phosphohydrolase activity|activation of acid phosphatidyl phosphatase activity|activation of phosphatic acid phosphatase activity|activation of phosphatic acid phosphohydrolase activity|activation of phosphatidate phosphatase activity|activation of phosphatidate phosphohydrolase activity|activation of phosphatidic acid phosphatase activity|positive regulation of 3-sn-phosphatidate phosphohydrolase activity|positive regulation of acid phosphatidyl phosphatase activity|positive regulation of phosphatic acid phosphatase activity|positive regulation of phosphatic acid phosphohydrolase activity|positive regulation of phosphatidate phosphohydrolase activity|positive regulation of phosphatidic acid phosphatase activity|up regulation of 3-sn-phosphatidate phosphohydrolase activity|up regulation of acid phosphatidyl phosphatase activity|up regulation of phosphatic acid phosphatase activity|up regulation of phosphatic acid phosphohydrolase activity|up regulation of phosphatidate phosphatase activity|up regulation of phosphatidate phosphohydrolase activity|up regulation of phosphatidic acid phosphatase activity|up-regulation of 3-sn-phosphatidate phosphohydrolase activity|up-regulation of acid phosphatidyl phosphatase activity|up-regulation of phosphatic acid phosphatase activity|up-regulation of phosphatic acid phosphohydrolase activity|up-regulation of phosphatidate phosphatase activity|up-regulation of phosphatidate phosphohydrolase activity|up-regulation of phosphatidic acid phosphatase activity|upregulation of 3-sn-phosphatidate phosphohydrolase activity|upregulation of acid phosphatidyl phosphatase activity|upregulation of phosphatic acid phosphatase activity|upregulation of phosphatic acid phosphohydrolase activity|upregulation of phosphatidate phosphatase activity|upregulation of phosphatidate phosphohydrolase activity|upregulation of phosphatidic acid phosphatase activity http://purl.obolibrary.org/obo/GO_1903740 gocheck_do_not_annotate GO:0048345 biolink:BiologicalProcess regulation of paraxial mesodermal cell fate determination Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination. go.json http://purl.obolibrary.org/obo/GO_0048345 GO:0048344 biolink:BiologicalProcess paraxial mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0048344 GO:0048354 biolink:BiologicalProcess mucilage biosynthetic process involved in seed coat development The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development. go.json mucilage anabolism during seed coat development|mucilage biosynthetic process during seed coat development|mucilage formation during seed coat development|mucilage synthesis during seed coat development http://purl.obolibrary.org/obo/GO_0048354 GO:0048353 biolink:CellularComponent primary endosperm nucleus Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac. go.json http://purl.obolibrary.org/obo/GO_0048353 GO:0048352 biolink:BiologicalProcess paraxial mesoderm structural organization The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure. go.json paraxial mesoderm structural organisation http://purl.obolibrary.org/obo/GO_0048352 GO:0048351 biolink:BiologicalProcess negative regulation of paraxial mesodermal cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification. go.json down regulation of paraxial mesodermal cell fate specification|down-regulation of paraxial mesodermal cell fate specification|downregulation of paraxial mesodermal cell fate specification|inhibition of paraxial mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048351 GO:0048350 biolink:BiologicalProcess positive regulation of paraxial mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification. go.json activation of paraxial mesodermal cell fate specification|stimulation of paraxial mesodermal cell fate specification|up regulation of paraxial mesodermal cell fate specification|up-regulation of paraxial mesodermal cell fate specification|upregulation of paraxial mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048350 GO:1903759 biolink:BiologicalProcess obsolete signal transduction involved in regulation of aerobic respiration OBSOLETE. Any signal transduction that is involved in regulation of aerobic respiration. go.json signaling cascade involved in regulation of aerobic respiration|signaling pathway involved in regulation of aerobic respiration|signalling cascade involved in regulation of aerobic respiration|signalling pathway involved in regulation of aerobic respiration True http://purl.obolibrary.org/obo/GO_1903759 GO:1903758 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903758 GO:1903757 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903757 GO:1903756 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903756 GO:1903755 biolink:BiologicalProcess positive regulation of SUMO transferase activity Any process that activates or increases the frequency, rate or extent of SUMO transferase activity. go.json activation of SMT3 conjugating enzyme|activation of SUMO conjugating enzyme activity|activation of SUMO transferase activity|positive regulation of SMT3 conjugating enzyme|positive regulation of SUMO conjugating enzyme activity|up regulation of SMT3 conjugating enzyme|up regulation of SUMO conjugating enzyme activity|up regulation of SUMO transferase activity|up-regulation of SMT3 conjugating enzyme|up-regulation of SUMO conjugating enzyme activity|up-regulation of SUMO transferase activity|upregulation of SMT3 conjugating enzyme|upregulation of SUMO conjugating enzyme activity|upregulation of SUMO transferase activity http://purl.obolibrary.org/obo/GO_1903755 gocheck_do_not_annotate GO:1903754 biolink:CellularComponent cortical microtubule plus-end The plus-end of a cortical microtubule. go.json cortical microtubule plus end http://purl.obolibrary.org/obo/GO_1903754 GO:0048359 biolink:BiologicalProcess mucilage metabolic process involved in seed coat development The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development. go.json mucilage metabolic process during seed coat development|mucilage metabolism during seed coat development http://purl.obolibrary.org/obo/GO_0048359 GO:1903753 biolink:BiologicalProcess negative regulation of p38MAPK cascade Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade. go.json down regulation of p38 MAPK cascade|down regulation of p38 cascade|down regulation of p38MAPK cascade|down-regulation of p38 MAPK cascade|down-regulation of p38 cascade|down-regulation of p38MAPK cascade|downregulation of p38 MAPK cascade|downregulation of p38 cascade|downregulation of p38MAPK cascade|inhibition of p38 MAPK cascade|inhibition of p38 cascade|inhibition of p38MAPK cascade|negative regulation of p38 MAPK cascade|negative regulation of p38 cascade http://purl.obolibrary.org/obo/GO_1903753 GO:0048358 biolink:BiologicalProcess mucilage pectin biosynthetic process The chemical reactions and pathways resulting in the formation of the pectin component of mucilage. go.json mucilage pectin anabolism|mucilage pectin biosynthesis|mucilage pectin formation|mucilage pectin synthesis http://purl.obolibrary.org/obo/GO_0048358 GO:1903752 biolink:BiologicalProcess positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. go.json activation of H2O2-induced intrinsic apoptotic signaling pathway|activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|activation of intrinsic apoptotic signaling pathway in response to H2O2|activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|positive regulation of H2O2-induced intrinsic apoptotic signaling pathway|positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway in response to H2O2|up regulation of H2O2-induced intrinsic apoptotic signaling pathway|up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|up regulation of intrinsic apoptotic signaling pathway in response to H2O2|up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|up-regulation of H2O2-induced intrinsic apoptotic signaling pathway|up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|up-regulation of intrinsic apoptotic signaling pathway in response to H2O2|up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|upregulation of H2O2-induced intrinsic apoptotic signaling pathway|upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|upregulation of intrinsic apoptotic signaling pathway in response to H2O2|upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide http://purl.obolibrary.org/obo/GO_1903752 GO:0048357 biolink:BiologicalProcess pedicel mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem. go.json pedicel mucilage anabolism|pedicel mucilage biosynthesis|pedicel mucilage formation|pedicel mucilage synthesis http://purl.obolibrary.org/obo/GO_0048357 GO:1903751 biolink:BiologicalProcess negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. go.json down regulation of H2O2-induced intrinsic apoptotic signaling pathway|down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|down regulation of intrinsic apoptotic signaling pathway in response to H2O2|down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down-regulation of H2O2-induced intrinsic apoptotic signaling pathway|down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|down-regulation of intrinsic apoptotic signaling pathway in response to H2O2|down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|downregulation of H2O2-induced intrinsic apoptotic signaling pathway|downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|downregulation of intrinsic apoptotic signaling pathway in response to H2O2|downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|inhibition of H2O2-induced intrinsic apoptotic signaling pathway|inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|inhibition of intrinsic apoptotic signaling pathway in response to H2O2|inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|negative regulation of H2O2-induced intrinsic apoptotic signaling pathway|negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to H2O2 http://purl.obolibrary.org/obo/GO_1903751 GO:0048356 biolink:BiologicalProcess root epithelial mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. go.json root epithelial mucilage anabolism|root epithelial mucilage biosynthesis|root epithelial mucilage formation|root epithelial mucilage synthesis http://purl.obolibrary.org/obo/GO_0048356 GO:0048355 biolink:BiologicalProcess root cap mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth. go.json root cap mucilage anabolism|root cap mucilage biosynthesis|root cap mucilage formation|root cap mucilage synthesis http://purl.obolibrary.org/obo/GO_0048355 GO:1903750 biolink:BiologicalProcess regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. go.json regulation of H2O2-induced intrinsic apoptotic signaling pathway|regulation of hydrogen peroxide-induced apoptosis|regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway in response to H2O2 http://purl.obolibrary.org/obo/GO_1903750 GO:1903760 biolink:BiologicalProcess regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. go.json regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903760 gocheck_do_not_annotate GO:0000387 biolink:BiologicalProcess spliceosomal snRNP assembly The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. go.json spliceosomal snRNP biogenesis http://purl.obolibrary.org/obo/GO_0000387 GO:0048365 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048365 GO:0048364 biolink:BiologicalProcess root development The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. go.json http://purl.obolibrary.org/obo/GO_0048364 GO:0000386 biolink:MolecularActivity second spliceosomal transesterification activity Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. Reactome:R-HSA-9770236 go.json 3'-splice site cleavage, exon ligation|lariat formation, 5'-splice site cleavage http://purl.obolibrary.org/obo/GO_0000386 GO:0048363 biolink:BiologicalProcess mucilage pectin metabolic process The chemical reactions and pathways involving the pectin component of mucilage. go.json mucilage pectin metabolism http://purl.obolibrary.org/obo/GO_0048363 GO:0000385 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000385 GO:0000384 biolink:MolecularActivity first spliceosomal transesterification activity Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. go.json lariat formation, 5'-splice site cleavage http://purl.obolibrary.org/obo/GO_0000384 GO:0048362 biolink:BiologicalProcess pedicel mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the flower stem. go.json pedicel mucilage metabolism http://purl.obolibrary.org/obo/GO_0048362 GO:0048361 biolink:BiologicalProcess root epithelial mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. go.json root epithelial mucilage metabolism http://purl.obolibrary.org/obo/GO_0048361 GO:0048360 biolink:BiologicalProcess root cap mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth. go.json root cap mucilage metabolism http://purl.obolibrary.org/obo/GO_0048360 GO:0000389 biolink:BiologicalProcess mRNA 3'-splice site recognition Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. go.json U12-type nuclear mRNA 3'-splice site recognition|U2-type nuclear mRNA 3'-splice site recognition|nuclear mRNA 3'-splice site recognition http://purl.obolibrary.org/obo/GO_0000389 GO:1903769 biolink:BiologicalProcess negative regulation of cell proliferation in bone marrow Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in bone marrow. go.json down regulation of bone marrow cell proliferation|down regulation of cell proliferation in bone marrow|down-regulation of bone marrow cell proliferation|down-regulation of cell proliferation in bone marrow|downregulation of bone marrow cell proliferation|downregulation of cell proliferation in bone marrow|inhibition of bone marrow cell proliferation|inhibition of cell proliferation in bone marrow|negative regulation of bone marrow cell proliferation http://purl.obolibrary.org/obo/GO_1903769 GO:0000388 biolink:BiologicalProcess spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). go.json 3'-splice site cleavage, exon ligation|U12-type spliceosome conformational change to release U4atac and U11|U2-type spliceosome conformational change to release U4 and U1|spliceosomal A1 complex biosynthesis|spliceosomal A1 complex formation|spliceosomal B2 complex biosynthesis|spliceosomal B2 complex formation http://purl.obolibrary.org/obo/GO_0000388 GO:1903768 biolink:CellularComponent taste receptor complex A protein complex which is capable of taste receptor activity. go.json http://purl.obolibrary.org/obo/GO_1903768 GO:1903767 biolink:CellularComponent sweet taste receptor complex A protein complex which is capable of sweet taste receptor activity. go.json http://purl.obolibrary.org/obo/GO_1903767 GO:1903766 biolink:BiologicalProcess positive regulation of potassium ion export across plasma membrane Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane. go.json activation of potassium export|activation of potassium ion export|activation of potassium ion export across plasma membrane|positive regulation of potassium export|positive regulation of potassium ion export|up regulation of potassium export|up regulation of potassium ion export|up regulation of potassium ion export across plasma membrane|up-regulation of potassium export|up-regulation of potassium ion export|up-regulation of potassium ion export across plasma membrane|upregulation of potassium export|upregulation of potassium ion export|upregulation of potassium ion export across plasma membrane http://purl.obolibrary.org/obo/GO_1903766 GO:1903765 biolink:BiologicalProcess negative regulation of potassium ion export across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane. go.json down regulation of potassium export|down regulation of potassium ion export|down regulation of potassium ion export across plasma membrane|down-regulation of potassium export|down-regulation of potassium ion export|down-regulation of potassium ion export across plasma membrane|downregulation of potassium export|downregulation of potassium ion export|downregulation of potassium ion export across plasma membrane|inhibition of potassium export|inhibition of potassium ion export|inhibition of potassium ion export across plasma membrane|negative regulation of potassium export|negative regulation of potassium ion export http://purl.obolibrary.org/obo/GO_1903765 GO:0000383 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000383 GO:1903764 biolink:BiologicalProcess regulation of potassium ion export across plasma membrane Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane. go.json regulation of potassium export|regulation of potassium export across plasma membrane|regulation of potassium ion export http://purl.obolibrary.org/obo/GO_1903764 GO:0048369 biolink:BiologicalProcess lateral mesoderm morphogenesis The process in which the anatomical structures of the lateral mesoderm are generated and organized. go.json lateral plate mesoderm morphogenesis http://purl.obolibrary.org/obo/GO_0048369 GO:1903763 biolink:MolecularActivity gap junction channel activity involved in cell communication by electrical coupling Any gap junction channel activity that is involved in cell communication by electrical coupling. go.json connexin involved in cell communication by electrical coupling|innexin channel activity involved in cell communication by electrical coupling|innexin involved in cell communication by electrical coupling http://purl.obolibrary.org/obo/GO_1903763 GO:0000382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000382 GO:0048368 biolink:BiologicalProcess lateral mesoderm development The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. go.json lateral plate mesoderm development http://purl.obolibrary.org/obo/GO_0048368 GO:1903762 biolink:BiologicalProcess positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. go.json activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903762 gocheck_do_not_annotate GO:0000381 biolink:BiologicalProcess regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. go.json regulation of alternative nuclear mRNA splicing, via spliceosome|splice site selection http://purl.obolibrary.org/obo/GO_0000381 GO:0048367 biolink:BiologicalProcess shoot system development The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure. go.json shoot development http://purl.obolibrary.org/obo/GO_0048367 GO:1903761 biolink:BiologicalProcess negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. go.json down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903761 gocheck_do_not_annotate GO:0048366 biolink:BiologicalProcess leaf development The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048366 GO:0000380 biolink:BiologicalProcess alternative mRNA splicing, via spliceosome The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. go.json alternative nuclear mRNA splicing, via spliceosome|splice site selection http://purl.obolibrary.org/obo/GO_0000380 GO:1903771 biolink:BiologicalProcess positive regulation of beta-galactosidase activity Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity. go.json activation of S 2107|activation of beta-D-galactanase activity|activation of beta-D-galactoside galactohydrolase activity|activation of beta-D-lactosidase activity|activation of beta-galactosidase activity|activation of beta-lactosidase activity|activation of exo-(1->4)-beta-D-galactanase activity|activation of hydrolact|activation of lactose hydrolysis|activation of lactozym|activation of maxilact|activation of oryzatym|activation of sumiklat|activation of trilactase activity|positive regulation of S 2107|positive regulation of beta-D-galactanase activity|positive regulation of beta-D-galactoside galactohydrolase activity|positive regulation of beta-D-lactosidase activity|positive regulation of beta-lactosidase activity|positive regulation of exo-(1->4)-beta-D-galactanase activity|positive regulation of hydrolact|positive regulation of lactose hydrolysis|positive regulation of lactozym|positive regulation of maxilact|positive regulation of oryzatym|positive regulation of sumiklat|positive regulation of trilactase activity|up regulation of S 2107|up regulation of beta-D-galactanase activity|up regulation of beta-D-galactoside galactohydrolase activity|up regulation of beta-D-lactosidase activity|up regulation of beta-galactosidase activity|up regulation of beta-lactosidase activity|up regulation of exo-(1->4)-beta-D-galactanase activity|up regulation of hydrolact|up regulation of lactose hydrolysis|up regulation of lactozym|up regulation of maxilact|up regulation of oryzatym|up regulation of sumiklat|up regulation of trilactase activity|up-regulation of S 2107|up-regulation of beta-D-galactanase activity|up-regulation of beta-D-galactoside galactohydrolase activity|up-regulation of beta-D-lactosidase activity|up-regulation of beta-galactosidase activity|up-regulation of beta-lactosidase activity|up-regulation of exo-(1->4)-beta-D-galactanase activity|up-regulation of hydrolact|up-regulation of lactose hydrolysis|up-regulation of lactozym|up-regulation of maxilact|up-regulation of oryzatym|up-regulation of sumiklat|up-regulation of trilactase activity|upregulation of S 2107|upregulation of beta-D-galactanase activity|upregulation of beta-D-galactoside galactohydrolase activity|upregulation of beta-D-lactosidase activity|upregulation of beta-galactosidase activity|upregulation of beta-lactosidase activity|upregulation of exo-(1->4)-beta-D-galactanase activity|upregulation of hydrolact|upregulation of lactose hydrolysis|upregulation of lactozym|upregulation of maxilact|upregulation of oryzatym|upregulation of sumiklat|upregulation of trilactase activity http://purl.obolibrary.org/obo/GO_1903771 gocheck_do_not_annotate GO:1903770 biolink:BiologicalProcess negative regulation of beta-galactosidase activity Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity. go.json down regulation of S 2107|down regulation of beta-D-galactanase activity|down regulation of beta-D-galactoside galactohydrolase activity|down regulation of beta-D-lactosidase activity|down regulation of beta-galactosidase activity|down regulation of beta-lactosidase activity|down regulation of exo-(1->4)-beta-D-galactanase activity|down regulation of hydrolact|down regulation of lactose hydrolysis|down regulation of lactozym|down regulation of maxilact|down regulation of oryzatym|down regulation of sumiklat|down regulation of trilactase activity|down-regulation of S 2107|down-regulation of beta-D-galactanase activity|down-regulation of beta-D-galactoside galactohydrolase activity|down-regulation of beta-D-lactosidase activity|down-regulation of beta-galactosidase activity|down-regulation of beta-lactosidase activity|down-regulation of exo-(1->4)-beta-D-galactanase activity|down-regulation of hydrolact|down-regulation of lactose hydrolysis|down-regulation of lactozym|down-regulation of maxilact|down-regulation of oryzatym|down-regulation of sumiklat|down-regulation of trilactase activity|downregulation of S 2107|downregulation of beta-D-galactanase activity|downregulation of beta-D-galactoside galactohydrolase activity|downregulation of beta-D-lactosidase activity|downregulation of beta-galactosidase activity|downregulation of beta-lactosidase activity|downregulation of exo-(1->4)-beta-D-galactanase activity|downregulation of hydrolact|downregulation of lactose hydrolysis|downregulation of lactozym|downregulation of maxilact|downregulation of oryzatym|downregulation of sumiklat|downregulation of trilactase activity|inhibition of S 2107|inhibition of beta-D-galactanase activity|inhibition of beta-D-galactoside galactohydrolase activity|inhibition of beta-D-lactosidase activity|inhibition of beta-galactosidase activity|inhibition of beta-lactosidase activity|inhibition of exo-(1->4)-beta-D-galactanase activity|inhibition of hydrolact|inhibition of lactose hydrolysis|inhibition of lactozym|inhibition of maxilact|inhibition of oryzatym|inhibition of sumiklat|inhibition of trilactase activity|negative regulation of S 2107|negative regulation of beta-D-galactanase activity|negative regulation of beta-D-galactoside galactohydrolase activity|negative regulation of beta-D-lactosidase activity|negative regulation of beta-lactosidase activity|negative regulation of exo-(1->4)-beta-D-galactanase activity|negative regulation of hydrolact|negative regulation of lactose hydrolysis|negative regulation of lactozym|negative regulation of maxilact|negative regulation of oryzatym|negative regulation of sumiklat|negative regulation of trilactase activity http://purl.obolibrary.org/obo/GO_1903770 gocheck_do_not_annotate GO:0048376 biolink:BiologicalProcess positive regulation of lateral mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination. go.json activation of lateral mesodermal cell fate determination|positive regulation of lateral plate mesodermal cell fate determination|stimulation of lateral mesodermal cell fate determination|up regulation of lateral mesodermal cell fate determination|up-regulation of lateral mesodermal cell fate determination|upregulation of lateral mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048376 GO:0000398 biolink:BiologicalProcess mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. go.json mRNA splicing|nuclear mRNA splicing via U12-type spliceosome|nuclear mRNA splicing via U2-type spliceosome|nuclear mRNA splicing, via spliceosome|pre-mRNA splicing|splicing AT-AC intron|splicing GT-AG intron http://purl.obolibrary.org/obo/GO_0000398 GO:0048375 biolink:BiologicalProcess negative regulation of lateral mesodermal cell fate determination Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination. go.json down regulation of lateral mesodermal cell fate determination|down-regulation of lateral mesodermal cell fate determination|downregulation of lateral mesodermal cell fate determination|inhibition of lateral mesodermal cell fate determination|negative regulation of lateral plate mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048375 GO:0000397 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000397 GO:0048374 biolink:BiologicalProcess regulation of lateral mesodermal cell fate determination Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination. go.json regulation of lateral mesoderm cell fate determination|regulation of lateral plate mesoderm cell fate determination|regulation of lateral plate mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048374 GO:0000396 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000396 GO:0000395 biolink:BiologicalProcess mRNA 5'-splice site recognition Recognition of the intron 5'-splice site by components of the assembling spliceosome. go.json U12-type nuclear mRNA 5' splice site recognition|U12-type nuclear mRNA 5'-splice site recognition|U2-type nuclear mRNA 5' splice site recognition|U2-type nuclear mRNA 5'-splice site recognition|nuclear mRNA 5' splice site recognition|nuclear mRNA 5'-splice site recognition|spliceosomal CC complex biosynthesis|spliceosomal CC complex formation|spliceosomal E complex biosynthesis|spliceosomal E complex formation|spliceosomal commitment complex biosynthesis|spliceosomal commitment complex formation http://purl.obolibrary.org/obo/GO_0000395 GO:0048373 biolink:BiologicalProcess lateral mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json lateral mesoderm cell fate determination|lateral plate mesoderm cell fate determination|lateral plate mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048373 GO:0048372 biolink:BiologicalProcess lateral mesodermal cell fate commitment The process in which a cell becomes committed to become a lateral mesoderm cell. go.json lateral mesoderm cell fate commitment|lateral plate mesoderm cell fate commitment|lateral plate mesodermal cell fate commitment http://purl.obolibrary.org/obo/GO_0048372 GO:0048371 biolink:BiologicalProcess lateral mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell. go.json lateral mesoderm cell differentiation|lateral plate mesoderm cell differentiation|lateral plate mesodermal cell differentiation http://purl.obolibrary.org/obo/GO_0048371 GO:0048370 biolink:BiologicalProcess lateral mesoderm formation The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. go.json lateral plate mesoderm biosynthesis|lateral plate mesoderm formation http://purl.obolibrary.org/obo/GO_0048370 GO:0000399 biolink:CellularComponent cellular bud neck septin structure Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle. go.json http://purl.obolibrary.org/obo/GO_0000399 GO:0000390 biolink:BiologicalProcess spliceosomal complex disassembly Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. go.json U12-type spliceosome disassembly|U2-type spliceosome disassembly|spliceosome complex disassembly|spliceosome disassembly http://purl.obolibrary.org/obo/GO_0000390 GO:1903779 biolink:BiologicalProcess regulation of cardiac conduction Any process that modulates the frequency, rate or extent of cardiac conduction. go.json http://purl.obolibrary.org/obo/GO_1903779 GO:1903778 biolink:BiologicalProcess protein localization to vacuolar membrane A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. go.json protein localisation in vacuolar membrane|protein localisation to vacuolar membrane|protein localization in vacuolar membrane http://purl.obolibrary.org/obo/GO_1903778 GO:1903777 biolink:MolecularActivity melibiose binding Binding to melibiose. go.json http://purl.obolibrary.org/obo/GO_1903777 GO:1903776 biolink:BiologicalProcess regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends. go.json http://purl.obolibrary.org/obo/GO_1903776 GO:1903775 biolink:BiologicalProcess regulation of DNA double-strand break processing Any process that modulates the frequency, rate or extent of DNA double-strand break processing. go.json http://purl.obolibrary.org/obo/GO_1903775 GO:0000394 biolink:BiologicalProcess RNA splicing, via endonucleolytic cleavage and ligation Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. go.json mRNA splicing http://purl.obolibrary.org/obo/GO_0000394 GO:1903774 biolink:BiologicalProcess positive regulation of viral budding via host ESCRT complex Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex. go.json activation of viral budding through the ESCRT machinery|activation of viral budding via host ESCRT complex|positive regulation of viral budding through the ESCRT machinery|up regulation of viral budding through the ESCRT machinery|up regulation of viral budding via host ESCRT complex|up-regulation of viral budding through the ESCRT machinery|up-regulation of viral budding via host ESCRT complex|upregulation of viral budding through the ESCRT machinery|upregulation of viral budding via host ESCRT complex http://purl.obolibrary.org/obo/GO_1903774 GO:0048379 biolink:BiologicalProcess positive regulation of lateral mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification. go.json activation of lateral mesodermal cell fate specification|positive regulation of lateral plate mesodermal cell fate specification|stimulation of lateral mesodermal cell fate specification|up regulation of lateral mesodermal cell fate specification|up-regulation of lateral mesodermal cell fate specification|upregulation of lateral mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048379 GO:0000393 biolink:BiologicalProcess spliceosomal conformational changes to generate catalytic conformation Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. go.json 3'-splice site cleavage, exon ligation http://purl.obolibrary.org/obo/GO_0000393 GO:1903773 biolink:BiologicalProcess negative regulation of viral budding via host ESCRT complex Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex. go.json down regulation of viral budding through the ESCRT machinery|down regulation of viral budding via host ESCRT complex|down-regulation of viral budding through the ESCRT machinery|down-regulation of viral budding via host ESCRT complex|downregulation of viral budding through the ESCRT machinery|downregulation of viral budding via host ESCRT complex|inhibition of viral budding through the ESCRT machinery|inhibition of viral budding via host ESCRT complex|negative regulation of viral budding through the ESCRT machinery http://purl.obolibrary.org/obo/GO_1903773 GO:0048378 biolink:BiologicalProcess regulation of lateral mesodermal cell fate specification Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification. go.json regulation of lateral plate mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048378 GO:0000392 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000392 GO:1903772 biolink:BiologicalProcess regulation of viral budding via host ESCRT complex Any process that modulates the frequency, rate or extent of viral budding via host ESCRT complex. go.json regulation of host-assisted viral budding|regulation of viral budding through the ESCRT machinery http://purl.obolibrary.org/obo/GO_1903772 GO:0048377 biolink:BiologicalProcess lateral mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json lateral mesoderm cell fate specification|lateral plate mesoderm cell fate specification|lateral plate mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048377 GO:0000391 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000391 GO:1903782 biolink:BiologicalProcess regulation of sodium ion import across plasma membrane Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_1903782 GO:1903781 biolink:BiologicalProcess positive regulation of cardiac conduction Any process that activates or increases the frequency, rate or extent of cardiac conduction. go.json activation of cardiac conduction|up regulation of cardiac conduction|up-regulation of cardiac conduction|upregulation of cardiac conduction http://purl.obolibrary.org/obo/GO_1903781 GO:1903780 biolink:BiologicalProcess negative regulation of cardiac conduction Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. go.json down regulation of cardiac conduction|down-regulation of cardiac conduction|downregulation of cardiac conduction|inhibition of cardiac conduction http://purl.obolibrary.org/obo/GO_1903780 GO:0000365 biolink:BiologicalProcess mRNA trans splicing, via spliceosome The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. go.json nuclear mRNA trans splicing, via U2-type spliceosome|nuclear mRNA trans splicing, via spliceosome http://purl.obolibrary.org/obo/GO_0000365 GO:0048387 biolink:BiologicalProcess negative regulation of retinoic acid receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. go.json down regulation of retinoic acid receptor signaling pathway|down-regulation of retinoic acid receptor signaling pathway|downregulation of retinoic acid receptor signaling pathway|inhibition of retinoic acid receptor signaling pathway|negative regulation of RAR signaling pathway|negative regulation of RAR signalling pathway|negative regulation of retinoic acid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0048387 GO:0097310 biolink:BiologicalProcess cap2 mRNA methylation Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA. go.json cap2 mRNA capping http://purl.obolibrary.org/obo/GO_0097310 GO:0048386 biolink:BiologicalProcess positive regulation of retinoic acid receptor signaling pathway Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity. go.json activation of retinoic acid receptor signaling pathway|positive regulation of RAR signaling pathway|positive regulation of retinoic acid receptor signalling pathway|stimulation of retinoic acid receptor signaling pathway|up regulation of retinoic acid receptor signaling pathway|up-regulation of retinoic acid receptor signaling pathway|upregulation of retinoic acid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0048386 GO:0000364 biolink:MolecularActivity obsolete second U2-type spliceosomal transesterification activity OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins. go.json 3'-splice site cleavage, exon ligation|second U2-type spliceosomal transesterification activity True http://purl.obolibrary.org/obo/GO_0000364 GO:0000363 biolink:MolecularActivity obsolete first U12-type spliceosomal transesterification activity OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins. go.json first U12-type spliceosomal transesterification activity|lariat formation, 5'-splice site cleavage True http://purl.obolibrary.org/obo/GO_0000363 GO:0097312 biolink:CellularComponent obsolete bacterial biofilm matrix component OBSOLETE. Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. go.json biofilm matrix part True http://purl.obolibrary.org/obo/GO_0097312 GO:0048385 biolink:BiologicalProcess regulation of retinoic acid receptor signaling pathway Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. go.json regulation of RAR signaling pathway|regulation of retinoic acid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0048385 GO:0097311 biolink:CellularComponent bacterial biofilm matrix A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. go.json http://purl.obolibrary.org/obo/GO_0097311 GO:0000362 biolink:MolecularActivity obsolete first U2-type spliceosomal transesterification activity OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins. go.json first U2-type spliceosomal transesterification activity|lariat formation, 5'-splice site cleavage True http://purl.obolibrary.org/obo/GO_0000362 GO:0048384 biolink:BiologicalProcess retinoic acid receptor signaling pathway The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. go.json RAR signaling pathway|retinoic acid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0048384 GO:0000369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000369 GO:0048383 biolink:BiologicalProcess mesectoderm development The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues. go.json http://purl.obolibrary.org/obo/GO_0048383 GO:0000368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000368 GO:0048382 biolink:BiologicalProcess mesendoderm development The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues. go.json http://purl.obolibrary.org/obo/GO_0048382 GO:0048381 biolink:BiologicalProcess lateral mesoderm structural organization The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure. go.json lateral mesoderm structural organisation|lateral plate mesoderm structural organization http://purl.obolibrary.org/obo/GO_0048381 GO:0000367 biolink:MolecularActivity obsolete second U12-type spliceosomal transesterification activity OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins. go.json 3'-splice site cleavage, exon ligation|second U12-type spliceosomal transesterification activity True http://purl.obolibrary.org/obo/GO_0000367 GO:0048380 biolink:BiologicalProcess negative regulation of lateral mesodermal cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification. go.json down regulation of lateral mesodermal cell fate specification|down-regulation of lateral mesodermal cell fate specification|downregulation of lateral mesodermal cell fate specification|inhibition of lateral mesodermal cell fate specification|negative regulation of lateral plate mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048380 GO:0000366 biolink:BiologicalProcess intergenic mRNA trans splicing The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing. go.json intergenic nuclear mRNA trans splicing http://purl.obolibrary.org/obo/GO_0000366 GO:1903789 biolink:BiologicalProcess regulation of amino acid transmembrane transport Any process that modulates the frequency, rate or extent of amino acid transmembrane transport. go.json regulation of amino acid membrane transport http://purl.obolibrary.org/obo/GO_1903789 GO:1903788 biolink:BiologicalProcess positive regulation of glutathione biosynthetic process Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process. go.json activation of glutathione anabolism|activation of glutathione biosynthesis|activation of glutathione biosynthetic process|activation of glutathione formation|activation of glutathione synthesis|positive regulation of glutathione anabolism|positive regulation of glutathione biosynthesis|positive regulation of glutathione formation|positive regulation of glutathione synthesis|up regulation of glutathione anabolism|up regulation of glutathione biosynthesis|up regulation of glutathione biosynthetic process|up regulation of glutathione formation|up regulation of glutathione synthesis|up-regulation of glutathione anabolism|up-regulation of glutathione biosynthesis|up-regulation of glutathione biosynthetic process|up-regulation of glutathione formation|up-regulation of glutathione synthesis|upregulation of glutathione anabolism|upregulation of glutathione biosynthesis|upregulation of glutathione biosynthetic process|upregulation of glutathione formation|upregulation of glutathione synthesis http://purl.obolibrary.org/obo/GO_1903788 GO:1903787 biolink:BiologicalProcess negative regulation of glutathione biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process. go.json down regulation of glutathione anabolism|down regulation of glutathione biosynthesis|down regulation of glutathione biosynthetic process|down regulation of glutathione formation|down regulation of glutathione synthesis|down-regulation of glutathione anabolism|down-regulation of glutathione biosynthesis|down-regulation of glutathione biosynthetic process|down-regulation of glutathione formation|down-regulation of glutathione synthesis|downregulation of glutathione anabolism|downregulation of glutathione biosynthesis|downregulation of glutathione biosynthetic process|downregulation of glutathione formation|downregulation of glutathione synthesis|inhibition of glutathione anabolism|inhibition of glutathione biosynthesis|inhibition of glutathione biosynthetic process|inhibition of glutathione formation|inhibition of glutathione synthesis|negative regulation of glutathione anabolism|negative regulation of glutathione biosynthesis|negative regulation of glutathione formation|negative regulation of glutathione synthesis http://purl.obolibrary.org/obo/GO_1903787 GO:1903786 biolink:BiologicalProcess regulation of glutathione biosynthetic process Any process that modulates the frequency, rate or extent of glutathione biosynthetic process. go.json regulation of glutathione anabolism|regulation of glutathione biosynthesis|regulation of glutathione formation|regulation of glutathione synthesis http://purl.obolibrary.org/obo/GO_1903786 GO:0000361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000361 GO:1903785 biolink:BiologicalProcess L-valine transmembrane transport The directed movement of L-valine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903785 GO:0000360 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000360 GO:0048389 biolink:BiologicalProcess intermediate mesoderm development The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. go.json http://purl.obolibrary.org/obo/GO_0048389 GO:1903784 biolink:BiologicalProcess positive regulation of sodium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane. go.json activation of sodium ion import across plasma membrane|up regulation of sodium ion import across plasma membrane|up-regulation of sodium ion import across plasma membrane|upregulation of sodium ion import across plasma membrane http://purl.obolibrary.org/obo/GO_1903784 GO:1903783 biolink:BiologicalProcess negative regulation of sodium ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane. go.json down regulation of sodium ion import across plasma membrane|down-regulation of sodium ion import across plasma membrane|downregulation of sodium ion import across plasma membrane|inhibition of sodium ion import across plasma membrane http://purl.obolibrary.org/obo/GO_1903783 GO:0048388 biolink:BiologicalProcess endosomal lumen acidification Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion. go.json http://purl.obolibrary.org/obo/GO_0048388 GO:1903793 biolink:BiologicalProcess positive regulation of monoatomic anion transport Any process that activates or increases the frequency, rate or extent of anion transport. go.json activation of anion transport|positive regulation of anion transport|up regulation of anion transport|up-regulation of anion transport|upregulation of anion transport http://purl.obolibrary.org/obo/GO_1903793 GO:1903792 biolink:BiologicalProcess negative regulation of monoatomic anion transport Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. go.json down regulation of anion transport|down-regulation of anion transport|downregulation of anion transport|inhibition of anion transport|negative regulation of anion transport http://purl.obolibrary.org/obo/GO_1903792 GO:1903791 biolink:BiologicalProcess uracil transmembrane transport The process in which uracil is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903791 GO:1903790 biolink:BiologicalProcess guanine nucleotide transmembrane transport The process in which a guanyl nucleotide is transported across a membrane. go.json guanyl nucleotide transmembrane transport http://purl.obolibrary.org/obo/GO_1903790 GO:0048390 biolink:BiologicalProcess intermediate mesoderm morphogenesis The process in which the anatomical structures of the intermediate mesoderm are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048390 GO:0097318 biolink:BiologicalProcess invasive growth in response to abiotic stimulus The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans. go.json http://purl.obolibrary.org/obo/GO_0097318 GO:0097317 biolink:BiologicalProcess invasive growth in response to biotic stimulus The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus. go.json http://purl.obolibrary.org/obo/GO_0097317 GO:0097319 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097319 GO:0097314 biolink:BiologicalProcess apoptosome assembly The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process. go.json apoptosome formation http://purl.obolibrary.org/obo/GO_0097314 GO:0097313 biolink:CellularComponent bacterial biofilm matrix surface The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. go.json http://purl.obolibrary.org/obo/GO_0097313 GO:0097316 biolink:BiologicalProcess cellular response to N-acetyl-D-glucosamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus. go.json http://purl.obolibrary.org/obo/GO_0097316 GO:0097315 biolink:BiologicalProcess response to N-acetyl-D-glucosamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus. go.json http://purl.obolibrary.org/obo/GO_0097315 GO:0048398 biolink:BiologicalProcess intermediate mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json intermediate mesoderm cell fate specification http://purl.obolibrary.org/obo/GO_0048398 GO:0097321 biolink:BiologicalProcess cell growth mode switching, filamentous to budding The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans. go.json http://purl.obolibrary.org/obo/GO_0097321 GO:0000376 biolink:BiologicalProcess RNA splicing, via transesterification reactions with guanosine as nucleophile Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile. go.json http://purl.obolibrary.org/obo/GO_0000376 GO:0000375 biolink:BiologicalProcess RNA splicing, via transesterification reactions Splicing of RNA via a series of two transesterification reactions. go.json RNA splicing factor activity, transesterification mechanism|pre-mRNA splicing factor activity|spliceosomal catalysis http://purl.obolibrary.org/obo/GO_0000375 goslim_pir GO:0097320 biolink:BiologicalProcess plasma membrane tubulation A membrane tubulation process occurring in a plasma membrane. go.json membrane tubulation|vesicle scission http://purl.obolibrary.org/obo/GO_0097320 GO:0048397 biolink:BiologicalProcess positive regulation of intermediate mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination. go.json activation of intermediate mesodermal cell fate determination|stimulation of intermediate mesodermal cell fate determination|up regulation of intermediate mesodermal cell fate determination|up-regulation of intermediate mesodermal cell fate determination|upregulation of intermediate mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048397 GO:0048396 biolink:BiologicalProcess negative regulation of intermediate mesodermal cell fate determination Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination. go.json down regulation of intermediate mesodermal cell fate determination|down-regulation of intermediate mesodermal cell fate determination|downregulation of intermediate mesodermal cell fate determination|inhibition of intermediate mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048396 GO:0097323 biolink:BiologicalProcess B cell adhesion The attachment of a B cell to another cell via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0097323 GO:0000374 biolink:BiologicalProcess Group III intron splicing The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved. go.json mRNA splicing http://purl.obolibrary.org/obo/GO_0000374 GO:0097322 biolink:MolecularActivity 7SK snRNA binding Binding to a 7SK small nuclear RNA (7SK snRNA). go.json 7SK small nuclear RNA binding http://purl.obolibrary.org/obo/GO_0097322 GO:0048395 biolink:BiologicalProcess regulation of intermediate mesodermal cell fate determination Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination. go.json http://purl.obolibrary.org/obo/GO_0048395 GO:0000373 biolink:BiologicalProcess Group II intron splicing The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. go.json mRNA splicing http://purl.obolibrary.org/obo/GO_0000373 GO:0048394 biolink:BiologicalProcess intermediate mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json intermediate mesoderm cell fate determination http://purl.obolibrary.org/obo/GO_0048394 GO:0048393 biolink:BiologicalProcess intermediate mesodermal cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell. go.json intermediate mesoderm cell fate commitment http://purl.obolibrary.org/obo/GO_0048393 GO:0000379 biolink:BiologicalProcess tRNA-type intron splice site recognition and cleavage RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs. go.json http://purl.obolibrary.org/obo/GO_0000379 GO:0048392 biolink:BiologicalProcess intermediate mesodermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell. go.json intermediate mesoderm cell differentiation http://purl.obolibrary.org/obo/GO_0048392 GO:0000378 biolink:BiologicalProcess RNA exon ligation The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction. go.json http://purl.obolibrary.org/obo/GO_0000378 GO:0000377 biolink:BiologicalProcess RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. go.json lariat RNA biosynthesis|lariat RNA formation http://purl.obolibrary.org/obo/GO_0000377 GO:0048391 biolink:BiologicalProcess intermediate mesoderm formation The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048391 GO:1903799 biolink:BiologicalProcess negative regulation of miRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of microRNA processing. go.json down regulation of gene silencing by miRNA, production of miRNAs|down regulation of miRNA biogenesis|down regulation of miRNA processing|down regulation of miRNA-mediated gene silencing, production of miRNAs|down regulation of microRNA biogenesis|down regulation of microRNA biosynthesis|down regulation of microRNA biosynthetic process|down regulation of microRNA metabolic process|down regulation of microRNA metabolism|down regulation of microRNA-mediated gene silencing, production of microRNAs|down regulation of production of miRNAs involved in gene silencing by miRNA|down regulation of production of microRNAs involved in gene silencing by microRNA|down-regulation of gene silencing by miRNA, production of miRNAs|down-regulation of miRNA biogenesis|down-regulation of miRNA processing|down-regulation of miRNA-mediated gene silencing, production of miRNAs|down-regulation of microRNA biogenesis|down-regulation of microRNA biosynthesis|down-regulation of microRNA biosynthetic process|down-regulation of microRNA metabolic process|down-regulation of microRNA metabolism|down-regulation of microRNA-mediated gene silencing, production of microRNAs|down-regulation of production of miRNAs involved in gene silencing by miRNA|down-regulation of production of microRNAs involved in gene silencing by microRNA|downregulation of gene silencing by miRNA, production of miRNAs|downregulation of miRNA biogenesis|downregulation of miRNA processing|downregulation of miRNA-mediated gene silencing, production of miRNAs|downregulation of microRNA biogenesis|downregulation of microRNA biosynthesis|downregulation of microRNA biosynthetic process|downregulation of microRNA metabolic process|downregulation of microRNA metabolism|downregulation of microRNA-mediated gene silencing, production of microRNAs|downregulation of production of miRNAs involved in gene silencing by miRNA|downregulation of production of microRNAs involved in gene silencing by microRNA|inhibition of gene silencing by miRNA, production of miRNAs|inhibition of miRNA biogenesis|inhibition of miRNA processing|inhibition of miRNA-mediated gene silencing, production of miRNAs|inhibition of microRNA biogenesis|inhibition of microRNA biosynthesis|inhibition of microRNA biosynthetic process|inhibition of microRNA metabolic process|inhibition of microRNA metabolism|inhibition of microRNA-mediated gene silencing, production of microRNAs|inhibition of production of miRNAs involved in gene silencing by miRNA|inhibition of production of microRNAs involved in gene silencing by microRNA|negative regulation of gene silencing by miRNA, production of miRNAs|negative regulation of miRNA biogenesis|negative regulation of miRNA maturation|negative regulation of miRNA-mediated gene silencing, production of miRNAs|negative regulation of microRNA biogenesis|negative regulation of microRNA biosynthesis|negative regulation of microRNA biosynthetic process|negative regulation of microRNA metabolic process|negative regulation of microRNA metabolism|negative regulation of microRNA-mediated gene silencing, production of microRNAs|negative regulation of production of miRNAs involved in gene silencing by miRNA|negative regulation of production of microRNAs involved in gene silencing by microRNA http://purl.obolibrary.org/obo/GO_1903799 GO:1903798 biolink:BiologicalProcess regulation of miRNA processing Any process that modulates the frequency, rate or extent of microRNA processing. go.json regulation of gene silencing by miRNA, production of miRNAs|regulation of miRNA biogenesis|regulation of miRNA maturation|regulation of microRNA biogenesis|regulation of microRNA biosynthesis|regulation of microRNA biosynthetic process|regulation of microRNA metabolic process|regulation of microRNA metabolism|regulation of microRNA processing|regulation of microRNA-mediated gene silencing, production of microRNAs http://purl.obolibrary.org/obo/GO_1903798 GO:1903797 biolink:BiologicalProcess positive regulation of inorganic anion transmembrane transport Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport. go.json activation of inorganic anion membrane transport|activation of inorganic anion transmembrane transport|activation of transmembrane inorganic anion transport|positive regulation of inorganic anion membrane transport|positive regulation of transmembrane inorganic anion transport|up regulation of inorganic anion membrane transport|up regulation of inorganic anion transmembrane transport|up regulation of transmembrane inorganic anion transport|up-regulation of inorganic anion membrane transport|up-regulation of inorganic anion transmembrane transport|up-regulation of transmembrane inorganic anion transport|upregulation of inorganic anion membrane transport|upregulation of inorganic anion transmembrane transport|upregulation of transmembrane inorganic anion transport http://purl.obolibrary.org/obo/GO_1903797 GO:0000372 biolink:BiologicalProcess Group I intron splicing The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize). go.json mRNA splicing http://purl.obolibrary.org/obo/GO_0000372 GO:1903796 biolink:BiologicalProcess negative regulation of inorganic anion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport. go.json down regulation of inorganic anion membrane transport|down regulation of inorganic anion transmembrane transport|down regulation of transmembrane inorganic anion transport|down-regulation of inorganic anion membrane transport|down-regulation of inorganic anion transmembrane transport|down-regulation of transmembrane inorganic anion transport|downregulation of inorganic anion membrane transport|downregulation of inorganic anion transmembrane transport|downregulation of transmembrane inorganic anion transport|inhibition of inorganic anion membrane transport|inhibition of inorganic anion transmembrane transport|inhibition of transmembrane inorganic anion transport|negative regulation of inorganic anion membrane transport|negative regulation of transmembrane inorganic anion transport http://purl.obolibrary.org/obo/GO_1903796 GO:0000371 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000371 GO:0000370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000370 GO:1903795 biolink:BiologicalProcess regulation of inorganic anion transmembrane transport Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport. go.json regulation of inorganic anion membrane transport|regulation of transmembrane inorganic anion transport http://purl.obolibrary.org/obo/GO_1903795 GO:0048399 biolink:BiologicalProcess regulation of intermediate mesodermal cell fate specification Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification. go.json http://purl.obolibrary.org/obo/GO_0048399 GO:1903794 biolink:MolecularActivity cortisol binding Binding to cortisol. go.json http://purl.obolibrary.org/obo/GO_1903794 GO:0097329 biolink:BiologicalProcess response to antimetabolite Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. go.json http://purl.obolibrary.org/obo/GO_0097329 GO:0097328 biolink:BiologicalProcess response to carboplatin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus. go.json http://purl.obolibrary.org/obo/GO_0097328 GO:0097325 biolink:BiologicalProcess melanocyte proliferation The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. go.json http://purl.obolibrary.org/obo/GO_0097325 GO:0097324 biolink:BiologicalProcess melanocyte migration The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. go.json http://purl.obolibrary.org/obo/GO_0097324 GO:0097327 biolink:BiologicalProcess response to antineoplastic agent Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms. go.json http://purl.obolibrary.org/obo/GO_0097327 GO:0097326 biolink:BiologicalProcess melanocyte adhesion The attachment of a melanocyte to another cell via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0097326 GO:0000343 biolink:CellularComponent plastid-encoded plastid RNA polymerase complex A A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex. go.json PEP-A http://purl.obolibrary.org/obo/GO_0000343 GO:0000342 biolink:MolecularActivity RNA cap 4 binding Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa. go.json http://purl.obolibrary.org/obo/GO_0000342 GO:0000341 biolink:MolecularActivity RNA trimethylguanosine cap binding Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans. go.json RNA m2,2,7G cap binding http://purl.obolibrary.org/obo/GO_0000341 GO:0000340 biolink:MolecularActivity RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. go.json RNA m7G cap binding http://purl.obolibrary.org/obo/GO_0000340 GO:0000347 biolink:CellularComponent THO complex The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. go.json http://purl.obolibrary.org/obo/GO_0000347 goslim_pir GO:0000346 biolink:CellularComponent transcription export complex The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. go.json TREX complex http://purl.obolibrary.org/obo/GO_0000346 goslim_pir GO:0000345 biolink:CellularComponent cytosolic DNA-directed RNA polymerase complex The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. go.json http://purl.obolibrary.org/obo/GO_0000345 GO:0000344 biolink:CellularComponent plastid-encoded plastid RNA polymerase complex B A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation. go.json PEP-B http://purl.obolibrary.org/obo/GO_0000344 GO:0000349 biolink:BiologicalProcess generation of catalytic spliceosome for first transesterification step Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. go.json U12-type catalytic spliceosome formation for first transesterification step|U2-type catalytic spliceosome formation for first transesterification step|catalytic spliceosome assembly for first transesterification step|formation of catalytic spliceosome for first transesterification step|spliceosomal A2-2 complex biosynthesis|spliceosomal A2-2 complex formation|spliceosomal C1 complex biosynthesis|spliceosomal C1 complex formation http://purl.obolibrary.org/obo/GO_0000349 GO:0000348 biolink:BiologicalProcess mRNA branch site recognition Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. go.json U12-type nuclear mRNA branch site recognition|U2-type nuclear mRNA branch site recognition|nuclear mRNA branch site recognition|spliceosomal A complex biosynthesis|spliceosomal A complex formation|spliceosomal B complex biosynthesis|spliceosomal B complex formation http://purl.obolibrary.org/obo/GO_0000348 GO:0000354 biolink:BiologicalProcess cis assembly of pre-catalytic spliceosome Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. go.json cis assembly of U12-type pre-catalytic spliceosome|cis assembly of U2-type pre-catalytic spliceosome|formation of spliceosomal A2-1 complex|formation of spliceosomal B1 complex|spliceosomal A2-1 complex biosynthesis|spliceosomal A2-1 complex formation|spliceosomal B1 complex biosynthesis|spliceosomal B1 complex formation http://purl.obolibrary.org/obo/GO_0000354 GO:0000353 biolink:BiologicalProcess formation of quadruple SL/U4/U5/U6 snRNP Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA. go.json http://purl.obolibrary.org/obo/GO_0000353 GO:0097301 biolink:BiologicalProcess obsolete regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter|potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0097301 GO:0000352 biolink:BiologicalProcess trans assembly of SL-containing precatalytic spliceosome Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA. go.json trans assembly of spliced leader-containing precatalytic spliceosome http://purl.obolibrary.org/obo/GO_0000352 GO:0097300 biolink:BiologicalProcess programmed necrotic cell death A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. go.json programmed cell death by necrosis|regulated necrosis http://purl.obolibrary.org/obo/GO_0097300 GO:0000351 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000351 GO:0000358 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000358 GO:0000357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000357 GO:0000356 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000356 GO:0000355 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000355 GO:0000350 biolink:BiologicalProcess generation of catalytic spliceosome for second transesterification step Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. go.json catalytic spliceosome assembly for second transesterification step|formation of catalytic U12-type spliceosome for second transesterification step|formation of catalytic U2-type spliceosome for second transesterification step|formation of catalytic spliceosome for second transesterification step|formation of spliceosomal A2-2 complex|formation of spliceosomal C1 complex|lariat formation, 5'-splice site cleavage|spliceosomal A2-3 complex biosynthesis|spliceosomal A2-3 complex formation|spliceosomal C2 complex biosynthesis|spliceosomal C2 complex formation http://purl.obolibrary.org/obo/GO_0000350 GO:0097307 biolink:BiologicalProcess response to farnesol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus. go.json http://purl.obolibrary.org/obo/GO_0097307 GO:0097306 biolink:BiologicalProcess cellular response to alcohol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. go.json http://purl.obolibrary.org/obo/GO_0097306 GO:0097309 biolink:BiologicalProcess cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA. go.json cap1 mRNA capping http://purl.obolibrary.org/obo/GO_0097309 GO:0000359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000359 GO:0097308 biolink:BiologicalProcess cellular response to farnesol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus. go.json http://purl.obolibrary.org/obo/GO_0097308 GO:0097303 biolink:BiologicalProcess lipoprotein biosynthetic process via N-acyl transfer The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex. go.json lipoprotein biosynthesis (N-acyl transfer) http://purl.obolibrary.org/obo/GO_0097303 GO:0097302 biolink:BiologicalProcess lipoprotein biosynthetic process via diacylglyceryl transfer The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex. go.json lipoprotein biosynthesis (diacylglyceryl transfer) http://purl.obolibrary.org/obo/GO_0097302 GO:0097305 biolink:BiologicalProcess response to alcohol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. go.json process resulting in tolerance to alcohol http://purl.obolibrary.org/obo/GO_0097305 GO:0097304 biolink:BiologicalProcess lipoprotein biosynthetic process via signal peptide cleavage The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex. go.json lipoprotein biosynthesis (signal peptide cleavage) http://purl.obolibrary.org/obo/GO_0097304 GO:1903709 biolink:BiologicalProcess uterine gland development The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure. go.json endometrial gland development|endometrium gland development|glandulae uterinae development|glandular part of endometrium development|set of uterine glands development|uterine glands development|uterine glands set development http://purl.obolibrary.org/obo/GO_1903709 GO:1903708 biolink:BiologicalProcess positive regulation of hemopoiesis Any process that activates or increases the frequency, rate or extent of hemopoiesis. go.json activation of blood cell biosynthesis|activation of blood cell formation|activation of haemopoiesis|activation of hematopoiesis|activation of hemopoiesis|positive regulation of blood cell biosynthesis|positive regulation of blood cell formation|positive regulation of haemopoiesis|positive regulation of hematopoiesis|up regulation of blood cell biosynthesis|up regulation of blood cell formation|up regulation of haemopoiesis|up regulation of hematopoiesis|up regulation of hemopoiesis|up-regulation of blood cell biosynthesis|up-regulation of blood cell formation|up-regulation of haemopoiesis|up-regulation of hematopoiesis|up-regulation of hemopoiesis|upregulation of blood cell biosynthesis|upregulation of blood cell formation|upregulation of haemopoiesis|upregulation of hematopoiesis|upregulation of hemopoiesis http://purl.obolibrary.org/obo/GO_1903708 GO:1903707 biolink:BiologicalProcess negative regulation of hemopoiesis Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. go.json down regulation of blood cell biosynthesis|down regulation of blood cell formation|down regulation of haemopoiesis|down regulation of hematopoiesis|down regulation of hemopoiesis|down-regulation of blood cell biosynthesis|down-regulation of blood cell formation|down-regulation of haemopoiesis|down-regulation of hematopoiesis|down-regulation of hemopoiesis|downregulation of blood cell biosynthesis|downregulation of blood cell formation|downregulation of haemopoiesis|downregulation of hematopoiesis|downregulation of hemopoiesis|inhibition of blood cell biosynthesis|inhibition of blood cell formation|inhibition of haemopoiesis|inhibition of hematopoiesis|inhibition of hemopoiesis|negative regulation of blood cell biosynthesis|negative regulation of blood cell formation|negative regulation of haemopoiesis|negative regulation of hematopoiesis http://purl.obolibrary.org/obo/GO_1903707 GO:1903706 biolink:BiologicalProcess regulation of hemopoiesis Any process that modulates the frequency, rate or extent of hemopoiesis. go.json regulation of blood cell biosynthesis|regulation of blood cell formation|regulation of haemopoiesis|regulation of hematopoiesis http://purl.obolibrary.org/obo/GO_1903706 GO:1903705 biolink:BiologicalProcess positive regulation of siRNA processing Any process that activates or increases the frequency, rate or extent of siRNA processing. go.json activation of RNA interference, production of guide RNAs|activation of RNA interference, production of siRNA|activation of production of guide RNAs involved in RNA interference|activation of production of siRNA involved in RNA interference|positive regulation of RNA interference, production of guide RNAs|positive regulation of RNA interference, production of siRNA|positive regulation of production of guide RNAs involved in RNA interference|positive regulation of production of siRNA involved in PTGS|positive regulation of production of siRNA involved in RNA interference|positive regulation of production of siRNA involved in post-transcriptional gene silencing by RNA|positive regulation of siRNA production|up regulation of RNA interference, production of guide RNAs|up regulation of RNA interference, production of siRNA|up regulation of production of guide RNAs involved in RNA interference|up regulation of production of siRNA involved in RNA interference|up-regulation of RNA interference, production of guide RNAs|up-regulation of RNA interference, production of siRNA|up-regulation of production of guide RNAs involved in RNA interference|up-regulation of production of siRNA involved in RNA interference|upregulation of RNA interference, production of guide RNAs|upregulation of RNA interference, production of siRNA|upregulation of production of guide RNAs involved in RNA interference|upregulation of production of siRNA involved in RNA interference http://purl.obolibrary.org/obo/GO_1903705 GO:1903704 biolink:BiologicalProcess negative regulation of siRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of siRNA processing. go.json down regulation of RNA interference, production of guide RNAs|down regulation of RNA interference, production of siRNA|down regulation of production of guide RNAs involved in RNA interference|down regulation of production of siRNA involved in RNA interference|down-regulation of RNA interference, production of guide RNAs|down-regulation of RNA interference, production of siRNA|down-regulation of production of guide RNAs involved in RNA interference|down-regulation of production of siRNA involved in RNA interference|downregulation of RNA interference, production of guide RNAs|downregulation of RNA interference, production of siRNA|downregulation of production of guide RNAs involved in RNA interference|downregulation of production of siRNA involved in RNA interference|inhibition of RNA interference, production of guide RNAs|inhibition of RNA interference, production of siRNA|inhibition of production of guide RNAs involved in RNA interference|inhibition of production of siRNA involved in RNA interference|negative regulation of RNA interference, production of guide RNAs|negative regulation of RNA interference, production of siRNA|negative regulation of production of guide RNAs involved in RNA interference|negative regulation of production of siRNA involved in PTGS|negative regulation of production of siRNA involved in RNA interference|negative regulation of production of siRNA involved in post-transcriptional gene silencing by RNA|negative regulation of siRNA production http://purl.obolibrary.org/obo/GO_1903704 GO:1903703 biolink:BiologicalProcess enterocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte. go.json http://purl.obolibrary.org/obo/GO_1903703 GO:1903702 biolink:BiologicalProcess esophagus development The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. go.json esophageal development|gullet development|oesophagus development http://purl.obolibrary.org/obo/GO_1903702 GO:0048307 biolink:MolecularActivity ferredoxin-nitrite reductase activity Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+. EC:1.7.7.1|MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN|RHEA:18041 go.json ammonia:ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0048307 GO:1903701 biolink:BiologicalProcess substantia propria of cornea development The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. go.json corneal stroma development|stroma of cornea development|substantia propria development http://purl.obolibrary.org/obo/GO_1903701 GO:0048306 biolink:MolecularActivity calcium-dependent protein binding Binding to a protein or protein complex in the presence of calcium. go.json http://purl.obolibrary.org/obo/GO_0048306 GO:1903700 biolink:BiologicalProcess caecum development The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure. go.json blind intestine development|blindgut development|caeca development|ceca development|cecum development|intestinum caecum development|intestinum crassum caecum development|intestinum crassum cecum development http://purl.obolibrary.org/obo/GO_1903700 GO:0048305 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048305 GO:0048304 biolink:BiologicalProcess positive regulation of isotype switching to IgG isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes. go.json activation of isotype switching to IgG isotypes|positive regulation of class switch recombination to IgG isotypes|positive regulation of class switching to IgG isotypes|positive regulation of isotype switch recombination to IgG isotypes|stimulation of isotype switching to IgG isotypes|up regulation of isotype switching to IgG isotypes|up-regulation of isotype switching to IgG isotypes|upregulation of isotype switching to IgG isotypes http://purl.obolibrary.org/obo/GO_0048304 GO:0048303 biolink:BiologicalProcess negative regulation of isotype switching to IgG isotypes Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes. go.json down regulation of isotype switching to IgG isotypes|down-regulation of isotype switching to IgG isotypes|downregulation of isotype switching to IgG isotypes|inhibition of isotype switching to IgG isotypes|negative regulation of class switch recombination to IgG isotypes|negative regulation of class switching to IgG isotypes|negative regulation of isotype switch recombination to IgG isotypes http://purl.obolibrary.org/obo/GO_0048303 GO:0048302 biolink:BiologicalProcess regulation of isotype switching to IgG isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes. go.json regulation of class switch recombination to IgG isotypes|regulation of class switching to IgG isotypes|regulation of isotype switch recombination to IgG isotypes http://purl.obolibrary.org/obo/GO_0048302 GO:0048301 biolink:BiologicalProcess positive regulation of isotype switching to IgD isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes. go.json activation of isotype switching to IgD isotypes|positive regulation of class switch recombination to IgD isotypes|positive regulation of class switching to IgD isotypes|positive regulation of isotype switch recombination to IgD isotypes|stimulation of isotype switching to IgD isotypes|up regulation of isotype switching to IgD isotypes|up-regulation of isotype switching to IgD isotypes|upregulation of isotype switching to IgD isotypes http://purl.obolibrary.org/obo/GO_0048301 GO:0048300 biolink:BiologicalProcess negative regulation of isotype switching to IgD isotypes Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes. go.json down regulation of isotype switching to IgD isotypes|down-regulation of isotype switching to IgD isotypes|downregulation of isotype switching to IgD isotypes|inhibition of isotype switching to IgD isotypes|negative regulation of class switch recombination to IgD isotypes|negative regulation of class switching to IgD isotypes|negative regulation of isotype switch recombination to IgD isotypes http://purl.obolibrary.org/obo/GO_0048300 GO:0048309 biolink:BiologicalProcess endoplasmic reticulum inheritance The partitioning of endoplasmic reticulum between daughter cells at cell division. go.json ER inheritance http://purl.obolibrary.org/obo/GO_0048309 GO:0048308 biolink:BiologicalProcess organelle inheritance The partitioning of organelles between daughter cells at cell division. go.json http://purl.obolibrary.org/obo/GO_0048308 goslim_pir|goslim_yeast GO:0048310 biolink:BiologicalProcess obsolete nucleus inheritance OBSOLETE. The partitioning of nuclei between daughter cells at cell division. go.json cell nucleus inheritance True http://purl.obolibrary.org/obo/GO_0048310 GO:1903719 biolink:BiologicalProcess regulation of I-kappaB phosphorylation Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation. go.json regulation of IKB phosphorylation|regulation of IkappaB phosphorylation|regulation of inhibitor of NF-kappaB phosphorylation|regulation of inhibitor of kappaB phosphorylation http://purl.obolibrary.org/obo/GO_1903719 GO:1903718 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903718 GO:1903717 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903717 GO:1903716 biolink:BiologicalProcess guanine transmembrane transport The process in which guanine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903716 GO:1903715 biolink:BiologicalProcess regulation of aerobic respiration Any process that modulates the frequency, rate or extent of aerobic respiration. go.json http://purl.obolibrary.org/obo/GO_1903715 GO:1903714 biolink:BiologicalProcess isoleucine transmembrane transport The directed movement of isoleucine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903714 GO:0048318 biolink:BiologicalProcess axial mesoderm development The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. go.json http://purl.obolibrary.org/obo/GO_0048318 GO:1903713 biolink:BiologicalProcess asparagine transmembrane transport The directed movement of asparagine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903713 GO:1903712 biolink:BiologicalProcess cysteine transmembrane transport The directed movement of cysteine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903712 GO:0048317 biolink:BiologicalProcess seed morphogenesis The process in which the anatomical structures of the seed are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048317 GO:0048316 biolink:BiologicalProcess seed development The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves. go.json http://purl.obolibrary.org/obo/GO_0048316 GO:1903711 biolink:BiologicalProcess spermidine transmembrane transport The process in which spermidine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903711 GO:0048315 biolink:BiologicalProcess conidium formation The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. go.json conidia biosynthesis|conidia formation http://purl.obolibrary.org/obo/GO_0048315 GO:1903710 biolink:BiologicalProcess spermine transmembrane transport The process in which spermine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903710 GO:0048314 biolink:BiologicalProcess embryo sac morphogenesis The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants. go.json female gametophyte morphogenesis http://purl.obolibrary.org/obo/GO_0048314 GO:0048313 biolink:BiologicalProcess Golgi inheritance The partitioning of Golgi apparatus between daughter cells at cell division. go.json Golgi apparatus inheritance|Golgi division|Golgi partitioning http://purl.obolibrary.org/obo/GO_0048313 GO:0048312 biolink:BiologicalProcess intracellular distribution of mitochondria Any process that establishes the spatial arrangement of mitochondria within the cell. go.json mitochondria positioning within cell|mitochondrion positioning within cell http://purl.obolibrary.org/obo/GO_0048312 GO:0048311 biolink:BiologicalProcess mitochondrion distribution Any process that establishes the spatial arrangement of mitochondria between and within cells. go.json distribution of mitochondria|mitochondrial distribution|positioning of mitochondria http://purl.obolibrary.org/obo/GO_0048311 GO:0048319 biolink:BiologicalProcess axial mesoderm morphogenesis The process in which the anatomical structures of the axial mesoderm are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048319 GO:0048321 biolink:BiologicalProcess axial mesodermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell. go.json axial mesoderm cell differentiation http://purl.obolibrary.org/obo/GO_0048321 GO:0048320 biolink:BiologicalProcess axial mesoderm formation The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048320 GO:1903729 biolink:BiologicalProcess regulation of plasma membrane organization Any process that modulates the frequency, rate or extent of plasma membrane organization. go.json regulation of plasma membrane organisation|regulation of plasma membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_1903729 GO:1903728 biolink:BiologicalProcess luteal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells. go.json lutein cell differentiation http://purl.obolibrary.org/obo/GO_1903728 GO:1903727 biolink:BiologicalProcess positive regulation of phospholipid metabolic process Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. go.json activation of phospholipid metabolic process|activation of phospholipid metabolism|positive regulation of phospholipid metabolism|up regulation of phospholipid metabolic process|up regulation of phospholipid metabolism|up-regulation of phospholipid metabolic process|up-regulation of phospholipid metabolism|upregulation of phospholipid metabolic process|upregulation of phospholipid metabolism http://purl.obolibrary.org/obo/GO_1903727 GO:1903726 biolink:BiologicalProcess negative regulation of phospholipid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process. go.json down regulation of phospholipid metabolic process|down regulation of phospholipid metabolism|down-regulation of phospholipid metabolic process|down-regulation of phospholipid metabolism|downregulation of phospholipid metabolic process|downregulation of phospholipid metabolism|inhibition of phospholipid metabolic process|inhibition of phospholipid metabolism|negative regulation of phospholipid metabolism http://purl.obolibrary.org/obo/GO_1903726 GO:1903725 biolink:BiologicalProcess regulation of phospholipid metabolic process Any process that modulates the frequency, rate or extent of phospholipid metabolic process. go.json regulation of phospholipid metabolism http://purl.obolibrary.org/obo/GO_1903725 GO:1903724 biolink:BiologicalProcess positive regulation of centriole elongation Any process that activates or increases the frequency, rate or extent of centriole elongation. go.json activation of centriole elongation|up regulation of centriole elongation|up-regulation of centriole elongation|upregulation of centriole elongation http://purl.obolibrary.org/obo/GO_1903724 GO:0048329 biolink:BiologicalProcess negative regulation of axial mesodermal cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification. go.json down regulation of axial mesodermal cell fate specification|down-regulation of axial mesodermal cell fate specification|downregulation of axial mesodermal cell fate specification|inhibition of axial mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048329 GO:1903723 biolink:BiologicalProcess negative regulation of centriole elongation Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation. go.json down regulation of centriole elongation|down-regulation of centriole elongation|downregulation of centriole elongation|inhibition of centriole elongation http://purl.obolibrary.org/obo/GO_1903723 GO:0048328 biolink:BiologicalProcess regulation of axial mesodermal cell fate specification Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification. go.json http://purl.obolibrary.org/obo/GO_0048328 GO:1903722 biolink:BiologicalProcess regulation of centriole elongation Any process that modulates the frequency, rate or extent of centriole elongation. go.json http://purl.obolibrary.org/obo/GO_1903722 GO:0048327 biolink:BiologicalProcess axial mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json axial mesoderm cell fate specification http://purl.obolibrary.org/obo/GO_0048327 GO:1903721 biolink:BiologicalProcess positive regulation of I-kappaB phosphorylation Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation. go.json activation of I-kappaB phosphorylation|activation of IKB phosphorylation|activation of IkappaB phosphorylation|activation of inhibitor of NF-kappaB phosphorylation|activation of inhibitor of kappaB phosphorylation|positive regulation of IKB phosphorylation|positive regulation of IkappaB phosphorylation|positive regulation of inhibitor of NF-kappaB phosphorylation|positive regulation of inhibitor of kappaB phosphorylation|up regulation of I-kappaB phosphorylation|up regulation of IKB phosphorylation|up regulation of IkappaB phosphorylation|up regulation of inhibitor of NF-kappaB phosphorylation|up regulation of inhibitor of kappaB phosphorylation|up-regulation of I-kappaB phosphorylation|up-regulation of IKB phosphorylation|up-regulation of IkappaB phosphorylation|up-regulation of inhibitor of NF-kappaB phosphorylation|up-regulation of inhibitor of kappaB phosphorylation|upregulation of I-kappaB phosphorylation|upregulation of IKB phosphorylation|upregulation of IkappaB phosphorylation|upregulation of inhibitor of NF-kappaB phosphorylation|upregulation of inhibitor of kappaB phosphorylation http://purl.obolibrary.org/obo/GO_1903721 GO:0048326 biolink:BiologicalProcess positive regulation of axial mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination. go.json activation of axial mesodermal cell fate determination|stimulation of axial mesodermal cell fate determination|up regulation of axial mesodermal cell fate determination|up-regulation of axial mesodermal cell fate determination|upregulation of axial mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048326 GO:1903720 biolink:BiologicalProcess negative regulation of I-kappaB phosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation. go.json down regulation of I-kappaB phosphorylation|down regulation of IKB phosphorylation|down regulation of IkappaB phosphorylation|down regulation of inhibitor of NF-kappaB phosphorylation|down regulation of inhibitor of kappaB phosphorylation|down-regulation of I-kappaB phosphorylation|down-regulation of IKB phosphorylation|down-regulation of IkappaB phosphorylation|down-regulation of inhibitor of NF-kappaB phosphorylation|down-regulation of inhibitor of kappaB phosphorylation|downregulation of I-kappaB phosphorylation|downregulation of IKB phosphorylation|downregulation of IkappaB phosphorylation|downregulation of inhibitor of NF-kappaB phosphorylation|downregulation of inhibitor of kappaB phosphorylation|inhibition of I-kappaB phosphorylation|inhibition of IKB phosphorylation|inhibition of IkappaB phosphorylation|inhibition of inhibitor of NF-kappaB phosphorylation|inhibition of inhibitor of kappaB phosphorylation|negative regulation of IKB phosphorylation|negative regulation of IkappaB phosphorylation|negative regulation of inhibitor of NF-kappaB phosphorylation|negative regulation of inhibitor of kappaB phosphorylation http://purl.obolibrary.org/obo/GO_1903720 GO:0048325 biolink:BiologicalProcess negative regulation of axial mesodermal cell fate determination Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination. go.json down regulation of axial mesodermal cell fate determination|down-regulation of axial mesodermal cell fate determination|downregulation of axial mesodermal cell fate determination|inhibition of axial mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048325 GO:0048324 biolink:BiologicalProcess regulation of axial mesodermal cell fate determination Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination. go.json http://purl.obolibrary.org/obo/GO_0048324 GO:0048323 biolink:BiologicalProcess axial mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json axial mesoderm cell fate determination http://purl.obolibrary.org/obo/GO_0048323 GO:0048322 biolink:BiologicalProcess axial mesodermal cell fate commitment The process in which a cell becomes committed to become an axial mesoderm cell. go.json axial mesoderm cell fate commitment http://purl.obolibrary.org/obo/GO_0048322 GO:0048332 biolink:BiologicalProcess mesoderm morphogenesis The process in which the anatomical structures of the mesoderm are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048332 GO:0048331 biolink:BiologicalProcess axial mesoderm structural organization The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure. go.json axial mesoderm structural organisation http://purl.obolibrary.org/obo/GO_0048331 GO:0048330 biolink:BiologicalProcess positive regulation of axial mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification. go.json activation of axial mesodermal cell fate specification|stimulation of axial mesodermal cell fate specification|up regulation of axial mesodermal cell fate specification|up-regulation of axial mesodermal cell fate specification|upregulation of axial mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048330 GO:0048339 biolink:BiologicalProcess paraxial mesoderm development The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. go.json http://purl.obolibrary.org/obo/GO_0048339 GO:0048338 biolink:BiologicalProcess mesoderm structural organization The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure. go.json mesoderm structural organisation http://purl.obolibrary.org/obo/GO_0048338 GO:0048337 biolink:BiologicalProcess positive regulation of mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification. go.json activation of mesodermal cell fate specification|stimulation of mesodermal cell fate specification|up regulation of mesodermal cell fate specification|up-regulation of mesodermal cell fate specification|upregulation of mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048337 GO:0048336 biolink:BiologicalProcess positive regulation of mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination. go.json activation of mesodermal cell fate determination|stimulation of mesodermal cell fate determination|up regulation of mesodermal cell fate determination|up-regulation of mesodermal cell fate determination|upregulation of mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048336 GO:0048335 biolink:BiologicalProcess negative regulation of mesodermal cell fate determination Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination. go.json down regulation of mesodermal cell fate determination|down-regulation of mesodermal cell fate determination|downregulation of mesodermal cell fate determination|inhibition of mesodermal cell fate determination http://purl.obolibrary.org/obo/GO_0048335 GO:1903730 biolink:BiologicalProcess regulation of phosphatidate phosphatase activity Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity. go.json regulation of 3-sn-phosphatidate phosphohydrolase activity|regulation of acid phosphatidyl phosphatase activity|regulation of phosphatic acid phosphatase activity|regulation of phosphatic acid phosphohydrolase activity|regulation of phosphatidate phosphohydrolase activity|regulation of phosphatidic acid phosphatase activity http://purl.obolibrary.org/obo/GO_1903730 gocheck_do_not_annotate GO:0048334 biolink:BiologicalProcess regulation of mesodermal cell fate determination Any process that modulates the frequency, rate or extent of mesoderm cell fate determination. go.json http://purl.obolibrary.org/obo/GO_0048334 GO:0048333 biolink:BiologicalProcess mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. go.json mesoderm cell differentiation http://purl.obolibrary.org/obo/GO_0048333 IAO:0100001 biolink:OntologyClass term replaced by go.json http://purl.obolibrary.org/obo/IAO_0100001 GO:0097475 biolink:BiologicalProcess motor neuron migration The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. go.json http://purl.obolibrary.org/obo/GO_0097475 GO:0097474 biolink:BiologicalProcess retinal cone cell apoptotic process Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. go.json cone photoreceptor apoptotic process http://purl.obolibrary.org/obo/GO_0097474 GO:0097477 biolink:BiologicalProcess lateral motor column neuron migration The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme. go.json http://purl.obolibrary.org/obo/GO_0097477 GO:0097476 biolink:BiologicalProcess spinal cord motor neuron migration The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. go.json http://purl.obolibrary.org/obo/GO_0097476 GO:0097471 biolink:CellularComponent mossy fiber rosette A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes. NIF_Subcellular:nlx_subcell_091021 go.json cerebellar mossy fiber to granule cell synapse http://purl.obolibrary.org/obo/GO_0097471 goslim_synapse GO:0097470 biolink:CellularComponent ribbon synapse Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm. NIF_Subcellular:sao1884931180 go.json synapsis fasciolaris http://purl.obolibrary.org/obo/GO_0097470 GO:0097473 biolink:BiologicalProcess retinal rod cell apoptotic process Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. go.json rod photoreceptor apoptotic process http://purl.obolibrary.org/obo/GO_0097473 GO:0097472 biolink:MolecularActivity cyclin-dependent protein kinase activity Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. go.json http://purl.obolibrary.org/obo/GO_0097472 GO:0097479 biolink:BiologicalProcess synaptic vesicle localization Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. go.json establishment and maintenance of synaptic vesicle localization|establishment and maintenance of synaptic vesicle position|synaptic vesicle localisation http://purl.obolibrary.org/obo/GO_0097479 GO:0097478 biolink:CellularComponent leaflet of membrane bilayer Any of the two layers of lipid molecules that constitute a membrane. go.json membrane leaflet http://purl.obolibrary.org/obo/GO_0097478 GO:0097486 biolink:CellularComponent multivesicular body lumen The volume enclosed by the outermost membrane of a multivesicular body. go.json http://purl.obolibrary.org/obo/GO_0097486 GO:0097485 biolink:BiologicalProcess neuron projection guidance The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. go.json neurite guidance|neuron process guidance|neuron protrusion guidance|neuronal cell projection guidance http://purl.obolibrary.org/obo/GO_0097485 GO:0097488 biolink:CellularComponent multivesicular body, internal vesicle membrane The lipid bilayer surrounding a multivesicular body internal vesicle. go.json http://purl.obolibrary.org/obo/GO_0097488 GO:0097487 biolink:CellularComponent multivesicular body, internal vesicle A membrane-bounded vesicle wholly contained within a multivesicular body. go.json http://purl.obolibrary.org/obo/GO_0097487 GO:0097482 biolink:CellularComponent muscle cell postsynaptic specialization A postsynaptic specialization that is part of a neuromuscular junction. go.json muscle cell postsynaptic density|muscle fiber postsynaptic density http://purl.obolibrary.org/obo/GO_0097482 GO:0000578 biolink:BiologicalProcess embryonic axis specification The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. go.json embryonic axis determination http://purl.obolibrary.org/obo/GO_0000578 GO:0097481 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097481 GO:0097484 biolink:BiologicalProcess dendrite extension Long distance growth of a single dendrite involved in cellular development. go.json http://purl.obolibrary.org/obo/GO_0097484 GO:0097483 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097483 GO:0097480 biolink:BiologicalProcess establishment of synaptic vesicle localization The directed movement of a synaptic vesicle or vesicles to a specific location. go.json establishment of synaptic vesicle localisation http://purl.obolibrary.org/obo/GO_0097480 GO:0097489 biolink:CellularComponent multivesicular body, internal vesicle lumen The volume enclosed by the membrane of the multivesicular body internal vesicle. go.json http://purl.obolibrary.org/obo/GO_0097489 GO:0097453 biolink:CellularComponent mesaxon Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide. NIF_Subcellular:sao2127666702 go.json mesaxon of Schwann cell http://purl.obolibrary.org/obo/GO_0097453 GO:0097452 biolink:CellularComponent GAIT complex A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. go.json IFN-gamma-activated inhibitor of translation complex|gamma interferon-activated inhibitor of translation complex http://purl.obolibrary.org/obo/GO_0097452 GO:0097455 biolink:CellularComponent spiny bracelet of Nageotte Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin. NIF_Subcellular:sao937871668 go.json http://purl.obolibrary.org/obo/GO_0097455 GO:0097454 biolink:CellularComponent Schwann cell microvillus Small finger-like extension of a Schwann cell that contacts the nodal membrane. NIF_Subcellular:sao1890444066 go.json http://purl.obolibrary.org/obo/GO_0097454 GO:0097451 biolink:CellularComponent glial limiting end-foot Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans. NIF_Subcellular:sao181458425 go.json glial limiting endfoot http://purl.obolibrary.org/obo/GO_0097451 GO:0097450 biolink:CellularComponent astrocyte end-foot Terminal process of astrocyte abutting non-neuronal surfaces in the brain. NIF_Subcellular:sao388182739 go.json astrocyte endfoot http://purl.obolibrary.org/obo/GO_0097450 GO:0097457 biolink:CellularComponent hippocampal mossy fiber An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. NIF_Subcellular:nlx_subcell_100312 go.json http://purl.obolibrary.org/obo/GO_0097457 GO:0097456 biolink:CellularComponent terminal loop Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath. NIF_Subcellular:sao924713546 go.json terminal loop of Schwann cell http://purl.obolibrary.org/obo/GO_0097456 GO:0097459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097459 GO:0097458 biolink:CellularComponent obsolete neuron part OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. go.json True http://purl.obolibrary.org/obo/GO_0097458 GO:0097464 biolink:CellularComponent thorny excrescence Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads. NIF_Subcellular:nlx_467 go.json http://purl.obolibrary.org/obo/GO_0097464 GO:0097463 biolink:CellularComponent gemmule Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex. NIF_Subcellular:nlx_subcell_1005003 go.json http://purl.obolibrary.org/obo/GO_0097463 GO:0097466 biolink:BiologicalProcess ubiquitin-dependent glycoprotein ERAD pathway An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component. go.json ER-associated glycoprotein degradation|glycoprotein ERAD|gpERAD|misfolded or incompletely synthesized glycoprotein catabolic process http://purl.obolibrary.org/obo/GO_0097466 GO:0097465 biolink:CellularComponent somatic spine Spine emanating from the cell soma of a neuron. NIF_Subcellular:sao2048514053 go.json http://purl.obolibrary.org/obo/GO_0097465 GO:0097460 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097460 GO:0097462 biolink:CellularComponent Lewy neurite Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease. NIF_Subcellular:sao601362597 go.json http://purl.obolibrary.org/obo/GO_0097462 GO:0097461 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097461 GO:0097468 biolink:BiologicalProcess programmed cell death in response to reactive oxygen species Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. go.json PCD in response to oxidative stress|PCD in response to reactive oxygen species|programmed cell death in response to oxidative stress|reactive oxygen species-mediated PCD|reactive oxygen species-mediated programmed cell death http://purl.obolibrary.org/obo/GO_0097468 GO:0097467 biolink:CellularComponent type III terminal bouton Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones. go.json type III terminal button http://purl.obolibrary.org/obo/GO_0097467 GO:0097469 biolink:MolecularActivity obsolete cyclin-dependent protein tyrosine kinase activity OBSOLETE. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. This reaction requires the binding of a regulatory cyclin subunit. go.json cyclin-dependent protein tyrosine kinase activity True http://purl.obolibrary.org/obo/GO_0097469 GO:0097497 biolink:BiologicalProcess blood vessel endothelial cell delamination The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet. go.json http://purl.obolibrary.org/obo/GO_0097497 GO:0097496 biolink:BiologicalProcess blood vessel lumen ensheathment A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel. go.json http://purl.obolibrary.org/obo/GO_0097496 GO:0097499 biolink:BiologicalProcess protein localization to non-motile cilium A process in which a protein is transported to, or maintained in, a location within a non-motile cilium. go.json protein localization to nonmotile primary cilium http://purl.obolibrary.org/obo/GO_0097499 GO:0097498 biolink:BiologicalProcess endothelial tube lumen extension Any endothelial tube morphogenesis process by which the tube is increased in length. go.json http://purl.obolibrary.org/obo/GO_0097498 GO:0000501 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000501 GO:0097493 biolink:MolecularActivity structural molecule activity conferring elasticity The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. go.json http://purl.obolibrary.org/obo/GO_0097493 GO:0000500 biolink:CellularComponent RNA polymerase I upstream activating factor complex A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p. go.json RNA polymerase I upstream activation factor complex|UAF http://purl.obolibrary.org/obo/GO_0000500 GO:0097492 biolink:BiologicalProcess sympathetic neuron axon guidance The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. go.json sympathetic neuron axon chemotaxis|sympathetic neuron axon growth cone guidance|sympathetic neuron axon pathfinding http://purl.obolibrary.org/obo/GO_0097492 GO:0097495 biolink:CellularComponent H-NS-Hha complex A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes. go.json http://purl.obolibrary.org/obo/GO_0097495 GO:0097494 biolink:BiologicalProcess regulation of vesicle size Any process that modulates the size of a vesicle. go.json http://purl.obolibrary.org/obo/GO_0097494 GO:0097491 biolink:BiologicalProcess sympathetic neuron projection guidance The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. go.json sympathetic neurite guidance|sympathetic neuron process guidance|sympathetic neuron protrusion guidance|sympathetic neuronal cell projection guidance http://purl.obolibrary.org/obo/GO_0097491 GO:0097490 biolink:BiologicalProcess sympathetic neuron projection extension Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. go.json sympathetic neurite extension|sympathetic neuron process extension|sympathetic neuron protrusion extension|sympathetic neuronal cell projection extension http://purl.obolibrary.org/obo/GO_0097490 GO:0000505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000505 GO:0000504 biolink:CellularComponent obsolete proteasome regulatory particle (sensu Bacteria) OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). go.json 26S proteasome|proteasome regulatory particle (sensu Bacteria) True http://purl.obolibrary.org/obo/GO_0000504 GO:0000503 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000503 GO:0000502 biolink:CellularComponent proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. go.json 26S proteasome|proteasome http://purl.obolibrary.org/obo/GO_0000502 goslim_pir GO:0000509 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000509 GO:0000508 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000508 GO:0000507 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000507 GO:0000506 biolink:CellularComponent glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. go.json GPI-GlcNAc transferase complex|GPI-GnT complex|GPI-N-acetylglucosaminyltransferase complex http://purl.obolibrary.org/obo/GO_0000506 GO:0000512 biolink:BiologicalProcess lncRNA-mediated post-transcriptional gene silencing A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs. go.json lncRNA-mediated gene silencing http://purl.obolibrary.org/obo/GO_0000512 GO:0000511 biolink:MolecularActivity H2A-H2B histone complex chaperone activity A histone chaperone that carries a H2A-H2B histone complex. go.json H2A-H2B histone carrier activity http://purl.obolibrary.org/obo/GO_0000511 GO:0000510 biolink:MolecularActivity H3-H4 histone complex chaperone activity A histone chaperone that carries a H3-H4 histone complex. go.json H3-H4 histone carrier activity|H3.1-H4 histone complex chaperone activity|H3.2-H4 histone complex chaperone activity|H3.3-H4 histone complex chaperone activity http://purl.obolibrary.org/obo/GO_0000510 GO:0000515 biolink:MolecularActivity aspartate:glutamate, proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in). RHEA:70783 go.json http://purl.obolibrary.org/obo/GO_0000515 GO:0000514 biolink:MolecularActivity 3-sulfino-L-alanine: proton, glutamate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out). RHEA:70967 go.json http://purl.obolibrary.org/obo/GO_0000514 GO:0000513 biolink:MolecularActivity actin severing activator activity Binds to and increases the activity of a actin severing protein. go.json http://purl.obolibrary.org/obo/GO_0000513 GO:0048464 biolink:BiologicalProcess flower calyx development The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048464 GO:0048463 biolink:BiologicalProcess carpel structural organization The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure. go.json carpel structural organisation http://purl.obolibrary.org/obo/GO_0048463 GO:0048462 biolink:BiologicalProcess carpel formation The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048462 GO:0048461 biolink:BiologicalProcess flower structural organization The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure. go.json flower structural organisation http://purl.obolibrary.org/obo/GO_0048461 GO:1903629 biolink:BiologicalProcess positive regulation of dUTP diphosphatase activity Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity. go.json activation of dUTP diphosphatase activity|activation of dUTP nucleotidohydrolase activity|activation of dUTP pyrophosphatase activity|activation of dUTPase activity|activation of deoxyuridine-triphosphatase activity|activation of desoxyuridine 5'-triphosphatase activity|activation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|positive regulation of dUTP nucleotidohydrolase activity|positive regulation of dUTP pyrophosphatase activity|positive regulation of dUTPase activity|positive regulation of deoxyuridine-triphosphatase activity|positive regulation of desoxyuridine 5'-triphosphatase activity|positive regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|up regulation of dUTP diphosphatase activity|up regulation of dUTP nucleotidohydrolase activity|up regulation of dUTP pyrophosphatase activity|up regulation of dUTPase activity|up regulation of deoxyuridine-triphosphatase activity|up regulation of desoxyuridine 5'-triphosphatase activity|up regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|up-regulation of dUTP diphosphatase activity|up-regulation of dUTP nucleotidohydrolase activity|up-regulation of dUTP pyrophosphatase activity|up-regulation of dUTPase activity|up-regulation of deoxyuridine-triphosphatase activity|up-regulation of desoxyuridine 5'-triphosphatase activity|up-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|upregulation of dUTP diphosphatase activity|upregulation of dUTP nucleotidohydrolase activity|upregulation of dUTP pyrophosphatase activity|upregulation of dUTPase activity|upregulation of deoxyuridine-triphosphatase activity|upregulation of desoxyuridine 5'-triphosphatase activity|upregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity http://purl.obolibrary.org/obo/GO_1903629 gocheck_do_not_annotate GO:0048460 biolink:BiologicalProcess flower formation The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048460 GO:1903628 biolink:BiologicalProcess obsolete negative regulation of dUTP diphosphatase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dUTP diphosphatase activity. go.json down regulation of dUTP diphosphatase activity|down regulation of dUTP nucleotidohydrolase activity|down regulation of dUTP pyrophosphatase activity|down regulation of dUTPase activity|down regulation of deoxyuridine-triphosphatase activity|down regulation of desoxyuridine 5'-triphosphatase activity|down regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|down-regulation of dUTP diphosphatase activity|down-regulation of dUTP nucleotidohydrolase activity|down-regulation of dUTP pyrophosphatase activity|down-regulation of dUTPase activity|down-regulation of deoxyuridine-triphosphatase activity|down-regulation of desoxyuridine 5'-triphosphatase activity|down-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|downregulation of dUTP diphosphatase activity|downregulation of dUTP nucleotidohydrolase activity|downregulation of dUTP pyrophosphatase activity|downregulation of dUTPase activity|downregulation of deoxyuridine-triphosphatase activity|downregulation of desoxyuridine 5'-triphosphatase activity|downregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|inhibition of dUTP diphosphatase activity|inhibition of dUTP nucleotidohydrolase activity|inhibition of dUTP pyrophosphatase activity|inhibition of dUTPase activity|inhibition of deoxyuridine-triphosphatase activity|inhibition of desoxyuridine 5'-triphosphatase activity|inhibition of desoxyuridine 5'-triphosphate nucleotidohydrolase activity|negative regulation of dUTP nucleotidohydrolase activity|negative regulation of dUTP pyrophosphatase activity|negative regulation of dUTPase activity|negative regulation of deoxyuridine-triphosphatase activity|negative regulation of desoxyuridine 5'-triphosphatase activity|negative regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity True http://purl.obolibrary.org/obo/GO_1903628 GO:1903627 biolink:BiologicalProcess obsolete regulation of dUTP diphosphatase activity OBSOLETE. Any process that modulates the frequency, rate or extent of dUTP diphosphatase activity. go.json regulation of dUTP nucleotidohydrolase activity|regulation of dUTP pyrophosphatase activity|regulation of dUTPase activity|regulation of deoxyuridine-triphosphatase activity|regulation of desoxyuridine 5'-triphosphatase activity|regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity True http://purl.obolibrary.org/obo/GO_1903627 GO:1903626 biolink:BiologicalProcess positive regulation of DNA catabolic process Any process that activates or increases the frequency, rate or extent of DNA catabolic process. go.json activation of DNA breakdown|activation of DNA catabolic process|activation of DNA catabolism|activation of DNA degradation|positive regulation of DNA breakdown|positive regulation of DNA catabolism|positive regulation of DNA degradation|up regulation of DNA breakdown|up regulation of DNA catabolic process|up regulation of DNA catabolism|up regulation of DNA degradation|up-regulation of DNA breakdown|up-regulation of DNA catabolic process|up-regulation of DNA catabolism|up-regulation of DNA degradation|upregulation of DNA breakdown|upregulation of DNA catabolic process|upregulation of DNA catabolism|upregulation of DNA degradation http://purl.obolibrary.org/obo/GO_1903626 GO:1903625 biolink:BiologicalProcess negative regulation of DNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. go.json down regulation of DNA breakdown|down regulation of DNA catabolic process|down regulation of DNA catabolism|down regulation of DNA degradation|down-regulation of DNA breakdown|down-regulation of DNA catabolic process|down-regulation of DNA catabolism|down-regulation of DNA degradation|downregulation of DNA breakdown|downregulation of DNA catabolic process|downregulation of DNA catabolism|downregulation of DNA degradation|inhibition of DNA breakdown|inhibition of DNA catabolic process|inhibition of DNA catabolism|inhibition of DNA degradation|negative regulation of DNA breakdown|negative regulation of DNA catabolism|negative regulation of DNA degradation http://purl.obolibrary.org/obo/GO_1903625 GO:1903624 biolink:BiologicalProcess regulation of DNA catabolic process Any process that modulates the frequency, rate or extent of DNA catabolic process. go.json regulation of DNA breakdown|regulation of DNA catabolism|regulation of DNA degradation http://purl.obolibrary.org/obo/GO_1903624 GO:1903623 biolink:BiologicalProcess negative regulation of RNA polymerase III activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity. go.json down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|down regulation of RNA polymerase III activity|down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|down-regulation of RNA polymerase III activity|downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|downregulation of RNA polymerase III activity|inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|inhibition of RNA polymerase III activity|negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_1903623 gocheck_do_not_annotate GO:1903622 biolink:BiologicalProcess regulation of RNA polymerase III activity Any process that modulates the frequency, rate or extent of RNA polymerase III activity. go.json regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_1903622 gocheck_do_not_annotate GO:0048469 biolink:BiologicalProcess cell maturation The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. go.json functional differentiation http://purl.obolibrary.org/obo/GO_0048469 goslim_pir GO:1903621 biolink:BiologicalProcess protein localization to photoreceptor connecting cilium A process in which a protein is transported to, or maintained in, a location within a photoreceptor connecting cilium. go.json protein localisation in photoreceptor connecting cilium|protein localisation to photoreceptor connecting cilium|protein localization in photoreceptor connecting cilium http://purl.obolibrary.org/obo/GO_1903621 GO:0048468 biolink:BiologicalProcess cell development The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. go.json terminal differentiation http://purl.obolibrary.org/obo/GO_0048468 goslim_candida GO:1903620 biolink:BiologicalProcess positive regulation of transdifferentiation Any process that activates or increases the frequency, rate or extent of transdifferentiation. go.json activation of transdifferentiation|up regulation of transdifferentiation|up-regulation of transdifferentiation|upregulation of transdifferentiation http://purl.obolibrary.org/obo/GO_1903620 GO:0048467 biolink:BiologicalProcess gynoecium development The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower. go.json pistil development http://purl.obolibrary.org/obo/GO_0048467 GO:0048466 biolink:BiologicalProcess androecium development The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048466 GO:0048465 biolink:BiologicalProcess corolla development The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048465 GO:0048475 biolink:CellularComponent coated membrane A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. go.json http://purl.obolibrary.org/obo/GO_0048475 GO:0048474 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048474 GO:0048473 biolink:BiologicalProcess D-methionine transport The directed movement of D-methionine into, out of, within, or between cells. go.json http://purl.obolibrary.org/obo/GO_0048473 GO:0097400 biolink:BiologicalProcess interleukin-17-mediated signaling pathway The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-17-mediated signaling pathway|IL-17-mediated signalling pathway|interleukin-17-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0097400 GO:0048472 biolink:MolecularActivity threonine-phosphate decarboxylase activity Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2. EC:4.1.1.81|KEGG_REACTION:R06530|MetaCyc:4.1.1.81-RXN|RHEA:11492 go.json CobD|L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]|L-threonine O-3-phosphate carboxy-lyase activity|L-threonine-O-3-phosphate decarboxylase activity http://purl.obolibrary.org/obo/GO_0048472 GO:0048471 biolink:CellularComponent perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus. go.json http://purl.obolibrary.org/obo/GO_0048471 GO:1903639 biolink:BiologicalProcess regulation of gastrin-induced gastric acid secretion Any process that modulates the frequency, rate or extent of gastrin-induced gastric acid secretion. go.json http://purl.obolibrary.org/obo/GO_1903639 GO:0048470 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048470 GO:1903638 biolink:BiologicalProcess positive regulation of protein insertion into mitochondrial outer membrane Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane. go.json activation of mitochondrial outer membrane protein import|activation of protein import into mitochondrial outer membrane|activation of protein insertion into mitochondrial outer membrane|activation of protein transport into mitochondrial outer membrane|positive regulation of mitochondrial outer membrane protein import|positive regulation of protein import into mitochondrial outer membrane|positive regulation of protein transport into mitochondrial outer membrane|up regulation of mitochondrial outer membrane protein import|up regulation of protein import into mitochondrial outer membrane|up regulation of protein insertion into mitochondrial outer membrane|up regulation of protein transport into mitochondrial outer membrane|up-regulation of mitochondrial outer membrane protein import|up-regulation of protein import into mitochondrial outer membrane|up-regulation of protein insertion into mitochondrial outer membrane|up-regulation of protein transport into mitochondrial outer membrane|upregulation of mitochondrial outer membrane protein import|upregulation of protein import into mitochondrial outer membrane|upregulation of protein insertion into mitochondrial outer membrane|upregulation of protein transport into mitochondrial outer membrane http://purl.obolibrary.org/obo/GO_1903638 GO:1903637 biolink:BiologicalProcess negative regulation of protein insertion into mitochondrial outer membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein insertion into mitochondrial outer membrane. go.json down regulation of mitochondrial outer membrane protein import|down regulation of protein import into mitochondrial outer membrane|down regulation of protein insertion into mitochondrial outer membrane|down regulation of protein transport into mitochondrial outer membrane|down-regulation of mitochondrial outer membrane protein import|down-regulation of protein import into mitochondrial outer membrane|down-regulation of protein insertion into mitochondrial outer membrane|down-regulation of protein transport into mitochondrial outer membrane|downregulation of mitochondrial outer membrane protein import|downregulation of protein import into mitochondrial outer membrane|downregulation of protein insertion into mitochondrial outer membrane|downregulation of protein transport into mitochondrial outer membrane|inhibition of mitochondrial outer membrane protein import|inhibition of protein import into mitochondrial outer membrane|inhibition of protein insertion into mitochondrial outer membrane|inhibition of protein transport into mitochondrial outer membrane|negative regulation of mitochondrial outer membrane protein import|negative regulation of protein import into mitochondrial outer membrane|negative regulation of protein transport into mitochondrial outer membrane http://purl.obolibrary.org/obo/GO_1903637 GO:1903636 biolink:BiologicalProcess regulation of protein insertion into mitochondrial outer membrane Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial outer membrane. go.json regulation of mitochondrial outer membrane protein import|regulation of protein import into mitochondrial outer membrane|regulation of protein transport into mitochondrial outer membrane http://purl.obolibrary.org/obo/GO_1903636 GO:1903635 biolink:BiologicalProcess obsolete positive regulation of leucine-tRNA ligase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of leucine-tRNA ligase activity. go.json activation of L-leucine:tRNALeu ligase (AMP-forming)|activation of leucine translase activity|activation of leucine-tRNA ligase activity|activation of leucine-tRNA synthetase activity|activation of leucyl-tRNA synthetase activity|activation of leucyl-transfer RNA synthetase activity|activation of leucyl-transfer ribonucleate synthetase activity|activation of leucyl-transfer ribonucleic acid synthetase activity|positive regulation of L-leucine:tRNALeu ligase (AMP-forming)|positive regulation of leucine translase activity|positive regulation of leucine-tRNA synthetase activity|positive regulation of leucyl-tRNA synthetase activity|positive regulation of leucyl-transfer RNA synthetase activity|positive regulation of leucyl-transfer ribonucleate synthetase activity|positive regulation of leucyl-transfer ribonucleic acid synthetase activity|up regulation of L-leucine:tRNALeu ligase (AMP-forming)|up regulation of leucine translase activity|up regulation of leucine-tRNA ligase activity|up regulation of leucine-tRNA synthetase activity|up regulation of leucyl-tRNA synthetase activity|up regulation of leucyl-transfer RNA synthetase activity|up regulation of leucyl-transfer ribonucleate synthetase activity|up regulation of leucyl-transfer ribonucleic acid synthetase activity|up-regulation of L-leucine:tRNALeu ligase (AMP-forming)|up-regulation of leucine translase activity|up-regulation of leucine-tRNA ligase activity|up-regulation of leucine-tRNA synthetase activity|up-regulation of leucyl-tRNA synthetase activity|up-regulation of leucyl-transfer RNA synthetase activity|up-regulation of leucyl-transfer ribonucleate synthetase activity|up-regulation of leucyl-transfer ribonucleic acid synthetase activity|upregulation of L-leucine:tRNALeu ligase (AMP-forming)|upregulation of leucine translase activity|upregulation of leucine-tRNA ligase activity|upregulation of leucine-tRNA synthetase activity|upregulation of leucyl-tRNA synthetase activity|upregulation of leucyl-transfer RNA synthetase activity|upregulation of leucyl-transfer ribonucleate synthetase activity|upregulation of leucyl-transfer ribonucleic acid synthetase activity True http://purl.obolibrary.org/obo/GO_1903635 GO:1903634 biolink:BiologicalProcess negative regulation of leucine-tRNA ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity. go.json down regulation of L-leucine:tRNALeu ligase (AMP-forming)|down regulation of leucine translase activity|down regulation of leucine-tRNA ligase activity|down regulation of leucine-tRNA synthetase activity|down regulation of leucyl-tRNA synthetase activity|down regulation of leucyl-transfer RNA synthetase activity|down regulation of leucyl-transfer ribonucleate synthetase activity|down regulation of leucyl-transfer ribonucleic acid synthetase activity|down-regulation of L-leucine:tRNALeu ligase (AMP-forming)|down-regulation of leucine translase activity|down-regulation of leucine-tRNA ligase activity|down-regulation of leucine-tRNA synthetase activity|down-regulation of leucyl-tRNA synthetase activity|down-regulation of leucyl-transfer RNA synthetase activity|down-regulation of leucyl-transfer ribonucleate synthetase activity|down-regulation of leucyl-transfer ribonucleic acid synthetase activity|downregulation of L-leucine:tRNALeu ligase (AMP-forming)|downregulation of leucine translase activity|downregulation of leucine-tRNA ligase activity|downregulation of leucine-tRNA synthetase activity|downregulation of leucyl-tRNA synthetase activity|downregulation of leucyl-transfer RNA synthetase activity|downregulation of leucyl-transfer ribonucleate synthetase activity|downregulation of leucyl-transfer ribonucleic acid synthetase activity|inhibition of L-leucine:tRNALeu ligase (AMP-forming)|inhibition of leucine translase activity|inhibition of leucine-tRNA ligase activity|inhibition of leucine-tRNA synthetase activity|inhibition of leucyl-tRNA synthetase activity|inhibition of leucyl-transfer RNA synthetase activity|inhibition of leucyl-transfer ribonucleate synthetase activity|inhibition of leucyl-transfer ribonucleic acid synthetase activity|negative regulation of L-leucine:tRNALeu ligase (AMP-forming)|negative regulation of leucine translase activity|negative regulation of leucine-tRNA synthetase activity|negative regulation of leucyl-tRNA synthetase activity|negative regulation of leucyl-transfer RNA synthetase activity|negative regulation of leucyl-transfer ribonucleate synthetase activity|negative regulation of leucyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_1903634 gocheck_do_not_annotate GO:1903633 biolink:BiologicalProcess obsolete regulation of leucine-tRNA ligase activity OBSOLETE. Any process that modulates the frequency, rate or extent of leucine-tRNA ligase activity. go.json regulation of L-leucine:tRNALeu ligase (AMP-forming)|regulation of leucine translase activity|regulation of leucine-tRNA synthetase activity|regulation of leucyl-tRNA synthetase activity|regulation of leucyl-transfer RNA synthetase activity|regulation of leucyl-transfer ribonucleate synthetase activity|regulation of leucyl-transfer ribonucleic acid synthetase activity True http://purl.obolibrary.org/obo/GO_1903633 GO:1903632 biolink:BiologicalProcess obsolete positive regulation of aminoacyl-tRNA ligase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity. go.json activation of aminoacyl-tRNA ligase activity|activation of aminoacyl-tRNA synthetase activity|activation of aminoacyl-tRNA synthetase auxiliary protein activity|positive regulation of aminoacyl-tRNA synthetase activity|positive regulation of aminoacyl-tRNA synthetase auxiliary protein activity|up regulation of aminoacyl-tRNA ligase activity|up regulation of aminoacyl-tRNA synthetase activity|up regulation of aminoacyl-tRNA synthetase auxiliary protein activity|up-regulation of aminoacyl-tRNA ligase activity|up-regulation of aminoacyl-tRNA synthetase activity|up-regulation of aminoacyl-tRNA synthetase auxiliary protein activity|upregulation of aminoacyl-tRNA ligase activity|upregulation of aminoacyl-tRNA synthetase activity|upregulation of aminoacyl-tRNA synthetase auxiliary protein activity True http://purl.obolibrary.org/obo/GO_1903632 GO:0048479 biolink:BiologicalProcess style development The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma. go.json http://purl.obolibrary.org/obo/GO_0048479 GO:1903631 biolink:BiologicalProcess obsolete negative regulation of aminoacyl-tRNA ligase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity. go.json down regulation of aminoacyl-tRNA ligase activity|down regulation of aminoacyl-tRNA synthetase activity|down regulation of aminoacyl-tRNA synthetase auxiliary protein activity|down-regulation of aminoacyl-tRNA ligase activity|down-regulation of aminoacyl-tRNA synthetase activity|down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity|downregulation of aminoacyl-tRNA ligase activity|downregulation of aminoacyl-tRNA synthetase activity|downregulation of aminoacyl-tRNA synthetase auxiliary protein activity|inhibition of aminoacyl-tRNA ligase activity|inhibition of aminoacyl-tRNA synthetase activity|inhibition of aminoacyl-tRNA synthetase auxiliary protein activity|negative regulation of aminoacyl-tRNA synthetase activity|negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity True http://purl.obolibrary.org/obo/GO_1903631 GO:0048478 biolink:BiologicalProcess obsolete replication fork protection OBSOLETE. Any process that prevents the collapse of stalled replication forks. go.json replication fork maintenance|replication fork stabilization True http://purl.obolibrary.org/obo/GO_0048478 GO:1903630 biolink:BiologicalProcess regulation of aminoacyl-tRNA ligase activity Any process that modulates the frequency, rate or extent of aminoacyl-tRNA ligase activity. go.json regulation of aminoacyl-tRNA synthetase activity|regulation of aminoacyl-tRNA synthetase auxiliary protein activity http://purl.obolibrary.org/obo/GO_1903630 gocheck_do_not_annotate GO:0048477 biolink:BiologicalProcess oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. Wikipedia:Oogenesis go.json ovum development http://purl.obolibrary.org/obo/GO_0048477 GO:0048476 biolink:CellularComponent Holliday junction resolvase complex An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated. go.json Mus81-Eme1 complex|Mus81-Eme1 holliday resolvase complex|Mus81-Eme2 complex|Mus81-Eme2 holliday resolvase complex|resolvasome http://purl.obolibrary.org/obo/GO_0048476 goslim_pir GO:0097409 biolink:CellularComponent glial cytoplasmic inclusion Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy. NIF_Subcellular:nlx_subcell_20090703 go.json GCI|Papp-Lantos body http://purl.obolibrary.org/obo/GO_0097409 GO:0097406 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097406 GO:0097405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097405 GO:0097408 biolink:CellularComponent fibrillary inclusion Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra. NIF_Subcellular:sao967812059 go.json http://purl.obolibrary.org/obo/GO_0097408 GO:0097407 biolink:CellularComponent Bunina body Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles. NIF_Subcellular:nlx_subcell_20090101 go.json http://purl.obolibrary.org/obo/GO_0097407 GO:0097402 biolink:BiologicalProcess neuroblast migration The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. go.json http://purl.obolibrary.org/obo/GO_0097402 GO:0097401 biolink:BiologicalProcess synaptic vesicle lumen acidification The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. go.json synaptic vesicle lumen pH reduction|synaptic vesicle proton loading http://purl.obolibrary.org/obo/GO_0097401 goslim_synapse GO:0097404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097404 GO:0097403 biolink:BiologicalProcess cellular response to raffinose Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus. go.json http://purl.obolibrary.org/obo/GO_0097403 GO:0048486 biolink:BiologicalProcess parasympathetic nervous system development The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. go.json http://purl.obolibrary.org/obo/GO_0048486 GO:0048485 biolink:BiologicalProcess sympathetic nervous system development The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0048485 GO:0048484 biolink:BiologicalProcess enteric nervous system development The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. go.json http://purl.obolibrary.org/obo/GO_0048484 GO:0048483 biolink:BiologicalProcess autonomic nervous system development The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. go.json http://purl.obolibrary.org/obo/GO_0048483 GO:0048482 biolink:BiologicalProcess plant ovule morphogenesis The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. go.json http://purl.obolibrary.org/obo/GO_0048482 GO:0048481 biolink:BiologicalProcess plant ovule development The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. go.json http://purl.obolibrary.org/obo/GO_0048481 GO:1903649 biolink:BiologicalProcess regulation of cytoplasmic transport Any process that modulates the frequency, rate or extent of cytoplasmic transport. go.json regulation of cytoplasmic streaming http://purl.obolibrary.org/obo/GO_1903649 GO:0048480 biolink:BiologicalProcess stigma development The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky. go.json http://purl.obolibrary.org/obo/GO_0048480 GO:1903648 biolink:BiologicalProcess positive regulation of chlorophyll catabolic process Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process. go.json activation of chlorophyll breakdown|activation of chlorophyll catabolic process|activation of chlorophyll catabolism|activation of chlorophyll degradation|positive regulation of chlorophyll breakdown|positive regulation of chlorophyll catabolism|positive regulation of chlorophyll degradation|up regulation of chlorophyll breakdown|up regulation of chlorophyll catabolic process|up regulation of chlorophyll catabolism|up regulation of chlorophyll degradation|up-regulation of chlorophyll breakdown|up-regulation of chlorophyll catabolic process|up-regulation of chlorophyll catabolism|up-regulation of chlorophyll degradation|upregulation of chlorophyll breakdown|upregulation of chlorophyll catabolic process|upregulation of chlorophyll catabolism|upregulation of chlorophyll degradation http://purl.obolibrary.org/obo/GO_1903648 GO:1903647 biolink:BiologicalProcess negative regulation of chlorophyll catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll catabolic process. go.json down regulation of chlorophyll breakdown|down regulation of chlorophyll catabolic process|down regulation of chlorophyll catabolism|down regulation of chlorophyll degradation|down-regulation of chlorophyll breakdown|down-regulation of chlorophyll catabolic process|down-regulation of chlorophyll catabolism|down-regulation of chlorophyll degradation|downregulation of chlorophyll breakdown|downregulation of chlorophyll catabolic process|downregulation of chlorophyll catabolism|downregulation of chlorophyll degradation|inhibition of chlorophyll breakdown|inhibition of chlorophyll catabolic process|inhibition of chlorophyll catabolism|inhibition of chlorophyll degradation|negative regulation of chlorophyll breakdown|negative regulation of chlorophyll catabolism|negative regulation of chlorophyll degradation http://purl.obolibrary.org/obo/GO_1903647 GO:1903646 biolink:BiologicalProcess positive regulation of chaperone-mediated protein folding Any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding. go.json activation of chaperone-mediated protein folding|up regulation of chaperone-mediated protein folding|up-regulation of chaperone-mediated protein folding|upregulation of chaperone-mediated protein folding http://purl.obolibrary.org/obo/GO_1903646 GO:1903645 biolink:BiologicalProcess negative regulation of chaperone-mediated protein folding Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding. go.json down regulation of chaperone-mediated protein folding|down-regulation of chaperone-mediated protein folding|downregulation of chaperone-mediated protein folding|inhibition of chaperone-mediated protein folding http://purl.obolibrary.org/obo/GO_1903645 GO:1903644 biolink:BiologicalProcess regulation of chaperone-mediated protein folding Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding. go.json http://purl.obolibrary.org/obo/GO_1903644 GO:1903643 biolink:BiologicalProcess positive regulation of recombination hotspot binding Any process that activates or increases the frequency, rate or extent of recombination hotspot binding. go.json activation of DNA binding, recombination hotspot|activation of recombination hotspot binding|positive regulation of DNA binding, recombination hotspot|up regulation of DNA binding, recombination hotspot|up regulation of recombination hotspot binding|up-regulation of DNA binding, recombination hotspot|up-regulation of recombination hotspot binding|upregulation of DNA binding, recombination hotspot|upregulation of recombination hotspot binding http://purl.obolibrary.org/obo/GO_1903643 gocheck_do_not_annotate GO:1903642 biolink:BiologicalProcess regulation of recombination hotspot binding Any process that modulates the frequency, rate or extent of recombination hotspot binding. go.json regulation of DNA binding, recombination hotspot http://purl.obolibrary.org/obo/GO_1903642 gocheck_do_not_annotate GO:0048489 biolink:BiologicalProcess synaptic vesicle transport The directed movement of synaptic vesicles. go.json synaptic vesicle fission|synaptic vesicle fusion|synaptic vesicle trafficking http://purl.obolibrary.org/obo/GO_0048489 goslim_synapse GO:0048488 biolink:BiologicalProcess synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. go.json synaptic vesicle retrieval http://purl.obolibrary.org/obo/GO_0048488 goslim_synapse GO:1903641 biolink:BiologicalProcess positive regulation of gastrin-induced gastric acid secretion Any process that activates or increases the frequency, rate or extent of gastrin-induced gastric acid secretion. go.json activation of gastrin-induced gastric acid secretion|up regulation of gastrin-induced gastric acid secretion|up-regulation of gastrin-induced gastric acid secretion|upregulation of gastrin-induced gastric acid secretion http://purl.obolibrary.org/obo/GO_1903641 GO:1903640 biolink:BiologicalProcess negative regulation of gastrin-induced gastric acid secretion Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion. go.json down regulation of gastrin-induced gastric acid secretion|down-regulation of gastrin-induced gastric acid secretion|downregulation of gastrin-induced gastric acid secretion|inhibition of gastrin-induced gastric acid secretion http://purl.obolibrary.org/obo/GO_1903640 GO:0048487 biolink:MolecularActivity beta-tubulin binding Binding to the microtubule constituent protein beta-tubulin. go.json beta tubulin binding http://purl.obolibrary.org/obo/GO_0048487 GO:1903650 biolink:BiologicalProcess negative regulation of cytoplasmic transport Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. go.json down regulation of cytoplasmic streaming|down regulation of cytoplasmic transport|down-regulation of cytoplasmic streaming|down-regulation of cytoplasmic transport|downregulation of cytoplasmic streaming|downregulation of cytoplasmic transport|inhibition of cytoplasmic streaming|inhibition of cytoplasmic transport|negative regulation of cytoplasmic streaming http://purl.obolibrary.org/obo/GO_1903650 GO:0048497 biolink:BiologicalProcess maintenance of floral organ identity The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0048497 GO:0048496 biolink:BiologicalProcess maintenance of animal organ identity The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0048496 GO:0048495 biolink:MolecularActivity Roundabout binding Binding to Roundabout (ROBO) receptor, a transmembrane receptor. go.json Roundabout receptor binding http://purl.obolibrary.org/obo/GO_0048495 GO:0048494 biolink:CellularComponent chromatophore ribulose bisphosphate carboxylase complex A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. go.json RubisCO complex http://purl.obolibrary.org/obo/GO_0048494 GO:0048493 biolink:CellularComponent plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. go.json RubisCO complex|plasma membrane ribulose bisphosphate carboxylase complex|ribulose bisphosphate carboxylase complex http://purl.obolibrary.org/obo/GO_0048493 GO:0048492 biolink:CellularComponent ribulose bisphosphate carboxylase complex A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. go.json RubisCO complex http://purl.obolibrary.org/obo/GO_0048492 goslim_pir GO:0048491 biolink:BiologicalProcess retrograde synaptic vesicle transport The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body. go.json retrograde axonal transport of synaptic vesicle http://purl.obolibrary.org/obo/GO_0048491 goslim_synapse GO:0048490 biolink:BiologicalProcess anterograde synaptic vesicle transport The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. go.json anterograde axonal transport of synaptic vesicle http://purl.obolibrary.org/obo/GO_0048490 goslim_synapse GO:1903659 biolink:BiologicalProcess regulation of complement-dependent cytotoxicity Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity. go.json http://purl.obolibrary.org/obo/GO_1903659 GO:1903658 biolink:BiologicalProcess positive regulation of type IV pilus biogenesis Any process that activates or increases the frequency, rate or extent of type IV pilus biogenesis. go.json activation of TFP biogenesis|activation of type 4 pilus biogenesis|activation of type IV fimbria assembly|activation of type IV fimbria biogenesis|activation of type IV fimbriae assembly|activation of type IV fimbriae biogenesis|activation of type IV fimbrial assembly|activation of type IV fimbrial biogenesis|activation of type IV fimbrium assembly|activation of type IV fimbrium biogenesis|activation of type IV pilus biogenesis|activation of type IV pilus biosynthesis|positive regulation of TFP biogenesis|positive regulation of type 4 pilus biogenesis|positive regulation of type IV fimbria assembly|positive regulation of type IV fimbria biogenesis|positive regulation of type IV fimbriae assembly|positive regulation of type IV fimbriae biogenesis|positive regulation of type IV fimbrial assembly|positive regulation of type IV fimbrial biogenesis|positive regulation of type IV fimbrium assembly|positive regulation of type IV fimbrium biogenesis|positive regulation of type IV pilus biosynthesis|up regulation of TFP biogenesis|up regulation of type 4 pilus biogenesis|up regulation of type IV fimbria assembly|up regulation of type IV fimbria biogenesis|up regulation of type IV fimbriae assembly|up regulation of type IV fimbriae biogenesis|up regulation of type IV fimbrial assembly|up regulation of type IV fimbrial biogenesis|up regulation of type IV fimbrium assembly|up regulation of type IV fimbrium biogenesis|up regulation of type IV pilus biogenesis|up regulation of type IV pilus biosynthesis|up-regulation of TFP biogenesis|up-regulation of type 4 pilus biogenesis|up-regulation of type IV fimbria assembly|up-regulation of type IV fimbria biogenesis|up-regulation of type IV fimbriae assembly|up-regulation of type IV fimbriae biogenesis|up-regulation of type IV fimbrial assembly|up-regulation of type IV fimbrial biogenesis|up-regulation of type IV fimbrium assembly|up-regulation of type IV fimbrium biogenesis|up-regulation of type IV pilus biogenesis|up-regulation of type IV pilus biosynthesis|upregulation of TFP biogenesis|upregulation of type 4 pilus biogenesis|upregulation of type IV fimbria assembly|upregulation of type IV fimbria biogenesis|upregulation of type IV fimbriae assembly|upregulation of type IV fimbriae biogenesis|upregulation of type IV fimbrial assembly|upregulation of type IV fimbrial biogenesis|upregulation of type IV fimbrium assembly|upregulation of type IV fimbrium biogenesis|upregulation of type IV pilus biogenesis|upregulation of type IV pilus biosynthesis http://purl.obolibrary.org/obo/GO_1903658 GO:1903657 biolink:BiologicalProcess negative regulation of type IV pilus biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of type IV pilus biogenesis. go.json down regulation of TFP biogenesis|down regulation of type 4 pilus biogenesis|down regulation of type IV fimbria assembly|down regulation of type IV fimbria biogenesis|down regulation of type IV fimbriae assembly|down regulation of type IV fimbriae biogenesis|down regulation of type IV fimbrial assembly|down regulation of type IV fimbrial biogenesis|down regulation of type IV fimbrium assembly|down regulation of type IV fimbrium biogenesis|down regulation of type IV pilus biogenesis|down regulation of type IV pilus biosynthesis|down-regulation of TFP biogenesis|down-regulation of type 4 pilus biogenesis|down-regulation of type IV fimbria assembly|down-regulation of type IV fimbria biogenesis|down-regulation of type IV fimbriae assembly|down-regulation of type IV fimbriae biogenesis|down-regulation of type IV fimbrial assembly|down-regulation of type IV fimbrial biogenesis|down-regulation of type IV fimbrium assembly|down-regulation of type IV fimbrium biogenesis|down-regulation of type IV pilus biogenesis|down-regulation of type IV pilus biosynthesis|downregulation of TFP biogenesis|downregulation of type 4 pilus biogenesis|downregulation of type IV fimbria assembly|downregulation of type IV fimbria biogenesis|downregulation of type IV fimbriae assembly|downregulation of type IV fimbriae biogenesis|downregulation of type IV fimbrial assembly|downregulation of type IV fimbrial biogenesis|downregulation of type IV fimbrium assembly|downregulation of type IV fimbrium biogenesis|downregulation of type IV pilus biogenesis|downregulation of type IV pilus biosynthesis|inhibition of TFP biogenesis|inhibition of type 4 pilus biogenesis|inhibition of type IV fimbria assembly|inhibition of type IV fimbria biogenesis|inhibition of type IV fimbriae assembly|inhibition of type IV fimbriae biogenesis|inhibition of type IV fimbrial assembly|inhibition of type IV fimbrial biogenesis|inhibition of type IV fimbrium assembly|inhibition of type IV fimbrium biogenesis|inhibition of type IV pilus biogenesis|inhibition of type IV pilus biosynthesis|negative regulation of TFP biogenesis|negative regulation of type 4 pilus biogenesis|negative regulation of type IV fimbria assembly|negative regulation of type IV fimbria biogenesis|negative regulation of type IV fimbriae assembly|negative regulation of type IV fimbriae biogenesis|negative regulation of type IV fimbrial assembly|negative regulation of type IV fimbrial biogenesis|negative regulation of type IV fimbrium assembly|negative regulation of type IV fimbrium biogenesis|negative regulation of type IV pilus biosynthesis http://purl.obolibrary.org/obo/GO_1903657 GO:1903656 biolink:BiologicalProcess regulation of type IV pilus biogenesis Any process that modulates the frequency, rate or extent of type IV pilus biogenesis. go.json regulation of TFP biogenesis|regulation of type 4 pilus biogenesis|regulation of type IV fimbria assembly|regulation of type IV fimbria biogenesis|regulation of type IV fimbriae assembly|regulation of type IV fimbriae biogenesis|regulation of type IV fimbrial assembly|regulation of type IV fimbrial biogenesis|regulation of type IV fimbrium assembly|regulation of type IV fimbrium biogenesis|regulation of type IV pilus biosynthesis http://purl.obolibrary.org/obo/GO_1903656 GO:1903655 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_1903655 GO:1903654 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_1903654 GO:1903653 biolink:BiologicalProcess modulation by symbiont of host cell motility Modulation of host cell motility by a symbiont of that host. go.json modulation by symbiont of host cell locomotion|modulation by symbiont of host cell movement|regulation by symbiont of host cell motility http://purl.obolibrary.org/obo/GO_1903653 GO:0048499 biolink:BiologicalProcess synaptic vesicle membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle. go.json SLMV biogenesis|synaptic vesicle membrane organisation|synaptic vesicle membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0048499 GO:1903652 biolink:BiologicalProcess modulation by virus of host cytoplasmic transport Modulation by an infecting virus of host cytoplasmic transport. go.json regulation by virus of host cytoplasmic streaming|regulation by virus of host cytoplasmic transport|viral modulation of host cytoplasmic trafficking http://purl.obolibrary.org/obo/GO_1903652 GO:1903651 biolink:BiologicalProcess positive regulation of cytoplasmic transport Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. go.json activation of cytoplasmic streaming|activation of cytoplasmic transport|positive regulation of cytoplasmic streaming|up regulation of cytoplasmic streaming|up regulation of cytoplasmic transport|up-regulation of cytoplasmic streaming|up-regulation of cytoplasmic transport|upregulation of cytoplasmic streaming|upregulation of cytoplasmic transport http://purl.obolibrary.org/obo/GO_1903651 GO:0048498 biolink:BiologicalProcess establishment of petal orientation The process that determines the orientation of petals with reference to the central axis. go.json http://purl.obolibrary.org/obo/GO_0048498 GO:1903661 biolink:BiologicalProcess positive regulation of complement-dependent cytotoxicity Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity. go.json activation of complement-dependent cytotoxicity|up regulation of complement-dependent cytotoxicity|up-regulation of complement-dependent cytotoxicity|upregulation of complement-dependent cytotoxicity http://purl.obolibrary.org/obo/GO_1903661 GO:1903660 biolink:BiologicalProcess negative regulation of complement-dependent cytotoxicity Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity. go.json down regulation of complement-dependent cytotoxicity|down-regulation of complement-dependent cytotoxicity|downregulation of complement-dependent cytotoxicity|inhibition of complement-dependent cytotoxicity http://purl.obolibrary.org/obo/GO_1903660 GO:0097431 biolink:CellularComponent mitotic spindle pole Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. go.json http://purl.obolibrary.org/obo/GO_0097431 GO:0000486 biolink:BiologicalProcess cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000486 GO:0097430 biolink:BiologicalProcess copper ion import across prospore membrane The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol. go.json copper ion import into ascospore-type prospore|copper ion transport into forespores http://purl.obolibrary.org/obo/GO_0097430 GO:0000485 biolink:BiologicalProcess cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000485 GO:0097433 biolink:CellularComponent dense body An electron dense body which may contain granules. NIF_Subcellular:sao730872736 go.json http://purl.obolibrary.org/obo/GO_0097433 GO:0000484 biolink:BiologicalProcess cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000484 GO:0097432 biolink:BiologicalProcess hippocampal pyramidal neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus. go.json http://purl.obolibrary.org/obo/GO_0097432 GO:0000483 biolink:BiologicalProcess endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species. go.json http://purl.obolibrary.org/obo/GO_0000483 GO:0000489 biolink:BiologicalProcess maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000489 GO:0000488 biolink:BiologicalProcess maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000488 GO:0000487 biolink:BiologicalProcess maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000487 GO:1903669 biolink:BiologicalProcess positive regulation of chemorepellent activity Any process that activates or increases the frequency, rate or extent of chemorepellent activity. go.json activation of chemorepellant activity|activation of chemorepellent activity|positive regulation of chemorepellant activity|up regulation of chemorepellant activity|up regulation of chemorepellent activity|up-regulation of chemorepellant activity|up-regulation of chemorepellent activity|upregulation of chemorepellant activity|upregulation of chemorepellent activity http://purl.obolibrary.org/obo/GO_1903669 gocheck_do_not_annotate GO:1903668 biolink:BiologicalProcess negative regulation of chemorepellent activity Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity. go.json down regulation of chemorepellant activity|down regulation of chemorepellent activity|down-regulation of chemorepellant activity|down-regulation of chemorepellent activity|downregulation of chemorepellant activity|downregulation of chemorepellent activity|inhibition of chemorepellant activity|inhibition of chemorepellent activity|negative regulation of chemorepellant activity http://purl.obolibrary.org/obo/GO_1903668 gocheck_do_not_annotate GO:1903667 biolink:BiologicalProcess regulation of chemorepellent activity Any process that modulates the frequency, rate or extent of chemorepellent activity. go.json regulation of chemorepellant activity http://purl.obolibrary.org/obo/GO_1903667 gocheck_do_not_annotate GO:1903666 biolink:BiologicalProcess positive regulation of asexual reproduction Any process that activates or increases the frequency, rate or extent of asexual reproduction. go.json activation of asexual reproduction|up regulation of asexual reproduction|up-regulation of asexual reproduction|upregulation of asexual reproduction http://purl.obolibrary.org/obo/GO_1903666 GO:1903665 biolink:BiologicalProcess negative regulation of asexual reproduction Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction. go.json down regulation of asexual reproduction|down-regulation of asexual reproduction|downregulation of asexual reproduction|inhibition of asexual reproduction http://purl.obolibrary.org/obo/GO_1903665 GO:0000482 biolink:BiologicalProcess maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000482 GO:1903664 biolink:BiologicalProcess regulation of asexual reproduction Any process that modulates the frequency, rate or extent of asexual reproduction. go.json http://purl.obolibrary.org/obo/GO_1903664 GO:0000481 biolink:BiologicalProcess maturation of 5S rRNA Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0000481 GO:0000480 biolink:BiologicalProcess endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. go.json endonucleolytic cleavage at A-prime|endonucleolytic cleavage at A0 http://purl.obolibrary.org/obo/GO_0000480 GO:1903663 biolink:BiologicalProcess L-altrarate catabolic process The chemical reactions and pathways resulting in the breakdown of L-altrarate. go.json L-altrarate(1-) breakdown|L-altrarate(1-) catabolism|L-altrarate(1-) degradation http://purl.obolibrary.org/obo/GO_1903663 GO:1903662 biolink:BiologicalProcess L-altrarate metabolic process The chemical reactions and pathways involving L-altrarate. go.json L-altrarate(1-) metabolism http://purl.obolibrary.org/obo/GO_1903662 GO:1903672 biolink:BiologicalProcess positive regulation of sprouting angiogenesis Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. go.json activation of sprouting angiogenesis|up regulation of sprouting angiogenesis|up-regulation of sprouting angiogenesis|upregulation of sprouting angiogenesis http://purl.obolibrary.org/obo/GO_1903672 GO:1903671 biolink:BiologicalProcess negative regulation of sprouting angiogenesis Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. go.json down regulation of sprouting angiogenesis|down-regulation of sprouting angiogenesis|downregulation of sprouting angiogenesis|inhibition of sprouting angiogenesis http://purl.obolibrary.org/obo/GO_1903671 GO:1903670 biolink:BiologicalProcess regulation of sprouting angiogenesis Any process that modulates the frequency, rate or extent of sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_1903670 GO:0097439 biolink:BiologicalProcess acquisition of desiccation tolerance The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state. go.json http://purl.obolibrary.org/obo/GO_0097439 GO:0097438 biolink:BiologicalProcess exit from dormancy The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. go.json release from dormancy http://purl.obolibrary.org/obo/GO_0097438 GO:0097435 biolink:BiologicalProcess supramolecular fiber organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. go.json extracellular fibril organisation|extracellular fibril organization|extracellular fibril organization and biogenesis|fibril organisation|fibril organization http://purl.obolibrary.org/obo/GO_0097435 GO:0097434 biolink:MolecularActivity succinate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in). go.json succinate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0097434 GO:0097437 biolink:BiologicalProcess maintenance of dormancy The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. go.json http://purl.obolibrary.org/obo/GO_0097437 GO:0097436 biolink:BiologicalProcess entry into dormancy The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. go.json induction of dormancy http://purl.obolibrary.org/obo/GO_0097436 GO:0097442 biolink:CellularComponent CA3 pyramidal cell dendrite A dendrite of a hippocampal CA3 pyramidal cell. NIF_Subcellular:nlx_subcell_1005001 go.json http://purl.obolibrary.org/obo/GO_0097442 GO:0000497 biolink:MolecularActivity DNA template activity Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule. go.json base pairing with DNA http://purl.obolibrary.org/obo/GO_0000497 GO:0097441 biolink:CellularComponent basal dendrite A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. NIF_Subcellular:sao1079900774 go.json basilar dendrite http://purl.obolibrary.org/obo/GO_0097441 GO:0000496 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000496 GO:0097444 biolink:CellularComponent spine apparatus A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum. NIF_Subcellular:sao725931194 go.json dense material http://purl.obolibrary.org/obo/GO_0097444 goslim_synapse GO:0000495 biolink:BiologicalProcess box H/ACA RNA 3'-end processing Any process involved in forming the mature 3' end of a box H/ACA RNA molecule. go.json box H/ACA RNA 3' end processing|box H/ACA sRNA 3'-end processing|box H/ACA snoRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0000495 GO:0097443 biolink:CellularComponent sorting endosome A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles. NIF_Subcellular:sao1028571114 go.json MVB-tubule complex http://purl.obolibrary.org/obo/GO_0097443 GO:0000494 biolink:BiologicalProcess box C/D RNA 3'-end processing Any process involved in forming the mature 3' end of a box C/D RNA molecule. go.json box C/D RNA 3' end processing|box C/D sRNA 3'-end processing|box C/D snoRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0000494 GO:0097440 biolink:CellularComponent apical dendrite A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. NIF_Subcellular:sao273773228 go.json http://purl.obolibrary.org/obo/GO_0097440 GO:0000499 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000499 GO:0000498 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000498 GO:1903679 biolink:BiologicalProcess positive regulation of cap-independent translational initiation Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation. go.json activation of cap-independent translational initiation|up regulation of cap-independent translational initiation|up-regulation of cap-independent translational initiation|upregulation of cap-independent translational initiation http://purl.obolibrary.org/obo/GO_1903679 GO:1903678 biolink:BiologicalProcess negative regulation of cap-independent translational initiation Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation. go.json down regulation of cap-independent translational initiation|down-regulation of cap-independent translational initiation|downregulation of cap-independent translational initiation|inhibition of cap-independent translational initiation http://purl.obolibrary.org/obo/GO_1903678 GO:1903677 biolink:BiologicalProcess regulation of cap-independent translational initiation Any process that modulates the frequency, rate or extent of cap-independent translational initiation. go.json http://purl.obolibrary.org/obo/GO_1903677 GO:1903676 biolink:BiologicalProcess positive regulation of cap-dependent translational initiation Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation. go.json activation of cap-dependent translational initiation|up regulation of cap-dependent translational initiation|up-regulation of cap-dependent translational initiation|upregulation of cap-dependent translational initiation http://purl.obolibrary.org/obo/GO_1903676 GO:0000493 biolink:BiologicalProcess box H/ACA snoRNP assembly The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. go.json box H/ACA small nucleolar ribonucleoprotein complex assembly http://purl.obolibrary.org/obo/GO_0000493 GO:1903675 biolink:BiologicalProcess negative regulation of cap-dependent translational initiation Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation. go.json down regulation of cap-dependent translational initiation|down-regulation of cap-dependent translational initiation|downregulation of cap-dependent translational initiation|inhibition of cap-dependent translational initiation http://purl.obolibrary.org/obo/GO_1903675 GO:0000492 biolink:BiologicalProcess box C/D snoRNP assembly The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. go.json box C/D small nucleolar ribonucleoprotein complex assembly http://purl.obolibrary.org/obo/GO_0000492 GO:0000491 biolink:BiologicalProcess small nucleolar ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex. go.json snoRNP assembly http://purl.obolibrary.org/obo/GO_0000491 GO:1903674 biolink:BiologicalProcess regulation of cap-dependent translational initiation Any process that modulates the frequency, rate or extent of cap-dependent translational initiation. go.json http://purl.obolibrary.org/obo/GO_1903674 GO:0000490 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000490 GO:1903673 biolink:BiologicalProcess mitotic cleavage furrow formation Any cleavage furrow formation that is involved in mitotic cell cycle. go.json cleavage furrow positioning involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903673 GO:1903683 biolink:BiologicalProcess positive regulation of epithelial cell-cell adhesion involved in epithelium migration Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. go.json activation of epithelial cell-cell adhesion involved in epithelium migration|up regulation of epithelial cell-cell adhesion involved in epithelium migration|up-regulation of epithelial cell-cell adhesion involved in epithelium migration|upregulation of epithelial cell-cell adhesion involved in epithelium migration http://purl.obolibrary.org/obo/GO_1903683 GO:1903682 biolink:BiologicalProcess negative regulation of epithelial cell-cell adhesion involved in epithelium migration Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. go.json down regulation of epithelial cell-cell adhesion involved in epithelium migration|down-regulation of epithelial cell-cell adhesion involved in epithelium migration|downregulation of epithelial cell-cell adhesion involved in epithelium migration|inhibition of epithelial cell-cell adhesion involved in epithelium migration http://purl.obolibrary.org/obo/GO_1903682 GO:1903681 biolink:BiologicalProcess regulation of epithelial cell-cell adhesion involved in epithelium migration Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. go.json http://purl.obolibrary.org/obo/GO_1903681 GO:1903680 biolink:BiologicalProcess acinar cell of sebaceous gland differentiation The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland. go.json sebocyte differentiation http://purl.obolibrary.org/obo/GO_1903680 GO:0097449 biolink:CellularComponent astrocyte projection A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. NIF_Subcellular:sao1630537580 go.json astrocyte process|peripheral astrocyte process|vellous process http://purl.obolibrary.org/obo/GO_0097449 GO:0097446 biolink:BiologicalProcess protein localization to eisosome filament A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1. go.json protein localization to linear eisosome http://purl.obolibrary.org/obo/GO_0097446 GO:0097445 biolink:CellularComponent presynaptic active zone dense projection Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered. NIF_Subcellular:sao494258938 go.json active zone dense projection|pre-synaptic active zone dense projection http://purl.obolibrary.org/obo/GO_0097445 GO:0097448 biolink:CellularComponent spine mat A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma. NIF_Subcellular:sao2128156969 go.json http://purl.obolibrary.org/obo/GO_0097448 GO:0097447 biolink:CellularComponent dendritic tree The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. NIF_Subcellular:sao172297168 go.json http://purl.obolibrary.org/obo/GO_0097447 GO:0000464 biolink:BiologicalProcess endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs. go.json endonucleolytic cleavage at A3 http://purl.obolibrary.org/obo/GO_0000464 GO:0000463 biolink:BiologicalProcess maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000463 GO:0000462 biolink:BiologicalProcess maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. go.json maturation of 18S rRNA http://purl.obolibrary.org/obo/GO_0000462 GO:0097411 biolink:BiologicalProcess hypoxia-inducible factor-1alpha signaling pathway The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. go.json HIF1alpha pathway|hypoxia-inducible factor signaling|hypoxia-inducible factor-1alpha signalling pathway http://purl.obolibrary.org/obo/GO_0097411 GO:0097410 biolink:BiologicalProcess hippocampal interneuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron. go.json http://purl.obolibrary.org/obo/GO_0097410 GO:0000461 biolink:BiologicalProcess endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. go.json endonucleolytic cleavage at site D http://purl.obolibrary.org/obo/GO_0000461 GO:0000468 biolink:BiologicalProcess generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json processing at B2 http://purl.obolibrary.org/obo/GO_0000468 GO:0000467 biolink:BiologicalProcess exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000467 GO:0000466 biolink:BiologicalProcess maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000466 GO:0000465 biolink:BiologicalProcess exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000465 GO:1903689 biolink:BiologicalProcess regulation of wound healing, spreading of epidermal cells Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells. go.json http://purl.obolibrary.org/obo/GO_1903689 GO:1903688 biolink:BiologicalProcess positive regulation of border follicle cell migration Any process that activates or increases the frequency, rate or extent of border follicle cell migration. go.json activation of border follicle cell migration http://purl.obolibrary.org/obo/GO_1903688 GO:0000460 biolink:BiologicalProcess maturation of 5.8S rRNA Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0000460 GO:1903687 biolink:BiologicalProcess negative regulation of border follicle cell migration Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration. go.json inhibition of border follicle cell migration http://purl.obolibrary.org/obo/GO_1903687 GO:1903684 biolink:BiologicalProcess regulation of border follicle cell migration Any process that modulates the frequency, rate or extent of border follicle cell migration. go.json regulation of border cell migration http://purl.obolibrary.org/obo/GO_1903684 GO:1903694 biolink:BiologicalProcess obsolete positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation. go.json activation of G1 mitotic cell cycle arrest in response to nitrogen starvation|activation of mitotic G1 cell cycle arrest in response to nitrogen starvation|positive regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation|up regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation|up regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation|up-regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation|up-regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation|upregulation of G1 mitotic cell cycle arrest in response to nitrogen starvation|upregulation of mitotic G1 cell cycle arrest in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_1903694 GO:1903693 biolink:BiologicalProcess obsolete regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation. go.json regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_1903693 GO:1903692 biolink:BiologicalProcess methionine import across plasma membrane The directed movement of methionine from outside of a cell, across the plasma membrane and into the cytosol. go.json methionine import|methionine import into cell http://purl.obolibrary.org/obo/GO_1903692 GO:1903691 biolink:BiologicalProcess positive regulation of wound healing, spreading of epidermal cells Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells. go.json activation of wound healing, spreading of epidermal cells|up regulation of wound healing, spreading of epidermal cells|up-regulation of wound healing, spreading of epidermal cells|upregulation of wound healing, spreading of epidermal cells http://purl.obolibrary.org/obo/GO_1903691 GO:1903690 biolink:BiologicalProcess negative regulation of wound healing, spreading of epidermal cells Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells. go.json down regulation of wound healing, spreading of epidermal cells|down-regulation of wound healing, spreading of epidermal cells|downregulation of wound healing, spreading of epidermal cells|inhibition of wound healing, spreading of epidermal cells http://purl.obolibrary.org/obo/GO_1903690 GO:0097417 biolink:CellularComponent nematosome Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles. NIF_Subcellular:sao138430598 go.json http://purl.obolibrary.org/obo/GO_0097417 GO:0097416 biolink:CellularComponent Lewy body-like hyaline inclusion Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments. NIF_Subcellular:nlx_subcell_20090105 go.json LBHI http://purl.obolibrary.org/obo/GO_0097416 GO:0097419 biolink:CellularComponent Pick body Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E. NIF_Subcellular:nlx_subcell_20090102 go.json http://purl.obolibrary.org/obo/GO_0097419 GO:0097418 biolink:CellularComponent neurofibrillary tangle Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. NIF_Subcellular:nlx_subcell_20090201|NIF_Subcellular:nlx_subcell_20090202|NIF_Subcellular:sao2409833926 go.json flame-shaped neurofibrillary tangle|star-shaped neurofibrillary tangle http://purl.obolibrary.org/obo/GO_0097418 GO:0000469 biolink:BiologicalProcess obsolete cleavage involved in rRNA processing OBSOLETE. Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. go.json cleavage during rRNA processing True http://purl.obolibrary.org/obo/GO_0000469 GO:0097413 biolink:CellularComponent Lewy body Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein. NIF_Subcellular:sao4933778419 go.json cytoplasmic inclusion http://purl.obolibrary.org/obo/GO_0097413 GO:0097412 biolink:CellularComponent hyaline inclusion A glass-like, pale intracellular inclusion. NIF_Subcellular:nlx_subcell_20090104 go.json pale body http://purl.obolibrary.org/obo/GO_0097412 GO:0097415 biolink:CellularComponent cortical Lewy body Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils. NIF_Subcellular:sao4040591221 go.json http://purl.obolibrary.org/obo/GO_0097415 GO:0097414 biolink:CellularComponent classical Lewy body Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils. NIF_Subcellular:sao4749542545 go.json brainstem Lewy body http://purl.obolibrary.org/obo/GO_0097414 GO:0097420 biolink:CellularComponent skein-like inclusion Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin. NIF_Subcellular:nlx_subcell_20090103 go.json http://purl.obolibrary.org/obo/GO_0097420 GO:0000475 biolink:BiologicalProcess maturation of 2S rRNA Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0000475 GO:0000474 biolink:BiologicalProcess maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000474 GO:0097422 biolink:CellularComponent tubular endosome A network of fine tubules in the vicinity of the Golgi complex and around the centriole. NIF_Subcellular:sao1570660411|NIF_Subcellular:sao694815499 go.json coated tip http://purl.obolibrary.org/obo/GO_0097422 GO:0000473 biolink:BiologicalProcess maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. go.json http://purl.obolibrary.org/obo/GO_0000473 GO:0000472 biolink:BiologicalProcess endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. go.json endonucleolytic cleavage at A1 http://purl.obolibrary.org/obo/GO_0000472 GO:0097421 biolink:BiologicalProcess liver regeneration The regrowth of lost or destroyed liver. go.json http://purl.obolibrary.org/obo/GO_0097421 GO:0000479 biolink:BiologicalProcess endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0000479 GO:0000478 biolink:BiologicalProcess obsolete endonucleolytic cleavage involved in rRNA processing OBSOLETE. Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA. go.json endonucleolytic cleavage during rRNA processing True http://purl.obolibrary.org/obo/GO_0000478 GO:0000477 biolink:BiologicalProcess generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. go.json processing at C1 http://purl.obolibrary.org/obo/GO_0000477 GO:0000476 biolink:BiologicalProcess maturation of 4.5S rRNA Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0000476 GO:1903699 biolink:BiologicalProcess tarsal gland development The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure. go.json Meibomian gland development|gland of Meibom development|glandula tarsales development|tarsoconjunctival gland development http://purl.obolibrary.org/obo/GO_1903699 GO:1903698 biolink:BiologicalProcess positive regulation of microvillus assembly Any process that activates or increases the frequency, rate or extent of microvillus assembly. go.json activation of microvillus assembly|activation of microvillus biogenesis|positive regulation of microvillus biogenesis|up regulation of microvillus assembly|up regulation of microvillus biogenesis|up-regulation of microvillus assembly|up-regulation of microvillus biogenesis|upregulation of microvillus assembly|upregulation of microvillus biogenesis http://purl.obolibrary.org/obo/GO_1903698 GO:0000471 biolink:BiologicalProcess endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events. go.json http://purl.obolibrary.org/obo/GO_0000471 GO:1903697 biolink:BiologicalProcess negative regulation of microvillus assembly Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. go.json down regulation of microvillus assembly|down regulation of microvillus biogenesis|down-regulation of microvillus assembly|down-regulation of microvillus biogenesis|downregulation of microvillus assembly|downregulation of microvillus biogenesis|inhibition of microvillus assembly|inhibition of microvillus biogenesis|negative regulation of microvillus biogenesis http://purl.obolibrary.org/obo/GO_1903697 GO:0000470 biolink:BiologicalProcess maturation of LSU-rRNA Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0000470 GO:1903696 biolink:BiologicalProcess protein localization to horsetail-astral microtubule array A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array. go.json protein localisation in horsetail-astral microtubule array|protein localisation to horsetail-astral microtubule array|protein localization in horsetail-astral microtubule array http://purl.obolibrary.org/obo/GO_1903696 GO:1903695 biolink:BiologicalProcess obsolete MAPK cascade involved in ascospore formation OBSOLETE. Any MAPK cascade that is involved in ascospore formation. go.json ERK/MAPK cascade involved in ascospore biosynthesis|ERK/MAPK cascade involved in ascospore formation|MAP kinase cascade involved in ascospore biosynthesis|MAP kinase cascade involved in ascospore formation|MAP kinase kinase kinase cascade involved in ascospore biosynthesis|MAP kinase kinase kinase cascade involved in ascospore formation|MAPK cascade involved in ascospore biosynthesis|MAPK signal transduction involved in ascospore biosynthesis|MAPK signal transduction involved in ascospore formation|MAPK signaling involved in ascospore biosynthesis|MAPK signaling involved in ascospore formation|MAPK signalling involved in ascospore biosynthesis|MAPK signalling involved in ascospore formation|MAPKKK cascade during sporulation involved in ascospore biosynthesis|MAPKKK cascade during sporulation involved in ascospore formation|MAPKKK cascade involved in ascospore biosynthesis|MAPKKK cascade involved in ascospore formation|mitogen-activated protein kinase cascade involved in ascospore biosynthesis|mitogen-activated protein kinase cascade involved in ascospore formation True http://purl.obolibrary.org/obo/GO_1903695 GO:0097428 biolink:BiologicalProcess protein maturation by iron-sulfur cluster transfer The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. go.json http://purl.obolibrary.org/obo/GO_0097428 GO:0097427 biolink:CellularComponent microtubule bundle An arrangement of closely apposed microtubules running parallel to each other. NIF_Subcellular:sao1872343973 go.json microtubule fascicle http://purl.obolibrary.org/obo/GO_0097427 GO:0097429 biolink:MolecularActivity amino acid ligation activity by nonribosomal peptide synthase Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase. go.json http://purl.obolibrary.org/obo/GO_0097429 GO:0097424 biolink:CellularComponent nucleolus-associated heterochromatin Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus. NIF_Subcellular:sao1210952635 go.json http://purl.obolibrary.org/obo/GO_0097424 GO:0097423 biolink:CellularComponent mitochondrion-associated adherens complex An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans. NIF_Subcellular:sao1933817066 go.json MAC|mitochondrial adhaerens complex http://purl.obolibrary.org/obo/GO_0097423 GO:0097426 biolink:CellularComponent glial filament An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes. NIF_Subcellular:sao1863852493 go.json http://purl.obolibrary.org/obo/GO_0097426 GO:0097425 biolink:CellularComponent obsolete smooth endoplasmic reticulum part OBSOLETE. Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER). NIF_Subcellular:sao184202831 go.json SER subcomponent True http://purl.obolibrary.org/obo/GO_0097425 GO:0048406 biolink:MolecularActivity nerve growth factor binding Binding to nerve growth factor (NGF). go.json NGF binding|beta-nerve growth factor binding|neurotrophin TRKA receptor activity http://purl.obolibrary.org/obo/GO_0048406 GO:0048405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048405 GO:0048404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048404 GO:0048403 biolink:MolecularActivity brain-derived neurotrophic factor binding Binding to brain-derived neurotrophic factor. go.json BDNF binding|neurotrophin TRKB receptor activity http://purl.obolibrary.org/obo/GO_0048403 GO:0048402 biolink:BiologicalProcess intermediate mesoderm structural organization The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure. go.json intermediate mesoderm structural organisation http://purl.obolibrary.org/obo/GO_0048402 GO:0048401 biolink:BiologicalProcess negative regulation of intermediate mesodermal cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification. go.json down regulation of intermediate mesodermal cell fate specification|down-regulation of intermediate mesodermal cell fate specification|downregulation of intermediate mesodermal cell fate specification|inhibition of intermediate mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048401 GO:0048400 biolink:BiologicalProcess positive regulation of intermediate mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification. go.json activation of intermediate mesodermal cell fate specification|stimulation of intermediate mesodermal cell fate specification|up regulation of intermediate mesodermal cell fate specification|up-regulation of intermediate mesodermal cell fate specification|upregulation of intermediate mesodermal cell fate specification http://purl.obolibrary.org/obo/GO_0048400 GO:0048409 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048409 GO:0048408 biolink:MolecularActivity epidermal growth factor binding Binding to epidermal growth factor. go.json EGF binding http://purl.obolibrary.org/obo/GO_0048408 GO:0048407 biolink:MolecularActivity platelet-derived growth factor binding Binding to platelet-derived growth factor. go.json PDGF binding http://purl.obolibrary.org/obo/GO_0048407 GO:0048417 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048417 GO:0048416 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048416 GO:0048415 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048415 GO:0048414 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048414 GO:0048413 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048413 GO:0048412 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048412 GO:0048411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048411 GO:0048410 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048410 GO:0048419 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048419 GO:0048418 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048418 GO:0048420 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048420 GO:0048428 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048428 GO:0048427 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048427 GO:0048426 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048426 GO:0048425 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048425 GO:0048424 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048424 GO:0048423 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048423 GO:0048422 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048422 GO:0048421 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048421 GO:0048429 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048429 GO:0048431 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048431 GO:0048430 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048430 GO:0048439 biolink:BiologicalProcess flower morphogenesis The process in which the anatomical structures of the flower are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048439 GO:0048438 biolink:BiologicalProcess floral whorl development The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant. go.json collective phyllome structure development http://purl.obolibrary.org/obo/GO_0048438 GO:0048437 biolink:BiologicalProcess floral organ development The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048437 GO:0048436 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048436 GO:0048435 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048435 GO:0048434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048434 GO:0048433 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048433 GO:0048432 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048432 GO:0048442 biolink:BiologicalProcess sepal development The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048442 GO:0048441 biolink:BiologicalProcess petal development The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048441 GO:1903609 biolink:BiologicalProcess negative regulation of inward rectifier potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity. go.json down regulation of Kir channel activity|down regulation of inward rectifier potassium channel activity|down-regulation of Kir channel activity|down-regulation of inward rectifier potassium channel activity|downregulation of Kir channel activity|downregulation of inward rectifier potassium channel activity|inhibition of Kir channel activity|inhibition of inward rectifier potassium channel activity|negative regulation of Kir channel activity http://purl.obolibrary.org/obo/GO_1903609 gocheck_do_not_annotate GO:0048440 biolink:BiologicalProcess carpel development The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style. go.json http://purl.obolibrary.org/obo/GO_0048440 GO:1903608 biolink:BiologicalProcess protein localization to cytoplasmic stress granule A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule. go.json protein localisation in cytoplasmic stress granule|protein localisation to cytoplasmic stress granule|protein localization in cytoplasmic stress granule|protein localization to stress granule http://purl.obolibrary.org/obo/GO_1903608 GO:1903607 biolink:BiologicalProcess cytochrome c biosynthetic process The chemical reactions and pathways resulting in the formation of cytochrome c. go.json cytochrome c anabolism|cytochrome c biosynthesis|cytochrome c formation|cytochrome c synthesis http://purl.obolibrary.org/obo/GO_1903607 GO:1903606 biolink:BiologicalProcess cytochrome c metabolic process The chemical reactions and pathways involving cytochrome c. go.json cytochrome c metabolism http://purl.obolibrary.org/obo/GO_1903606 GO:1903605 biolink:BiologicalProcess cytochrome biosynthetic process The chemical reactions and pathways resulting in the formation of a cytochrome. go.json cytochrome anabolism|cytochrome biosynthesis|cytochrome formation|cytochrome synthesis http://purl.obolibrary.org/obo/GO_1903605 GO:1903604 biolink:BiologicalProcess cytochrome metabolic process The chemical reactions and pathways involving a cytochrome. go.json cytochrome metabolism http://purl.obolibrary.org/obo/GO_1903604 GO:1903603 biolink:BiologicalProcess thermospermine biosynthetic process The chemical reactions and pathways resulting in the formation of thermospermine. go.json thermospermine anabolism|thermospermine biosynthesis|thermospermine formation|thermospermine synthesis http://purl.obolibrary.org/obo/GO_1903603 GO:0048449 biolink:BiologicalProcess floral organ formation The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048449 GO:1903602 biolink:BiologicalProcess thermospermine catabolic process The chemical reactions and pathways resulting in the breakdown of thermospermine. go.json thermospermine breakdown|thermospermine catabolism|thermospermine degradation http://purl.obolibrary.org/obo/GO_1903602 GO:0048448 biolink:BiologicalProcess stamen morphogenesis The process in which the anatomical structures of the stamen are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048448 GO:1903601 biolink:BiologicalProcess thermospermine metabolic process The chemical reactions and pathways involving thermospermine. go.json thermospermine metabolism http://purl.obolibrary.org/obo/GO_1903601 GO:1903600 biolink:CellularComponent glutaminase complex A protein complex which is capable of glutaminase activity. go.json Sno1p-Snz1p http://purl.obolibrary.org/obo/GO_1903600 GO:0048447 biolink:BiologicalProcess sepal morphogenesis The process in which the anatomical structures of the sepal are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048447 GO:0048446 biolink:BiologicalProcess petal morphogenesis The process in which the anatomical structures of the petal are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048446 GO:0048445 biolink:BiologicalProcess carpel morphogenesis The process in which the anatomical structures of the carpel are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048445 GO:0048444 biolink:BiologicalProcess floral organ morphogenesis The process in which the anatomical structures of the floral organ are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048444 GO:0048443 biolink:BiologicalProcess stamen development The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048443 GO:0048453 biolink:BiologicalProcess sepal formation The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048453 GO:0048452 biolink:BiologicalProcess petal structural organization The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure. go.json petal structural organisation http://purl.obolibrary.org/obo/GO_0048452 GO:0048451 biolink:BiologicalProcess petal formation The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048451 GO:1903619 biolink:BiologicalProcess negative regulation of transdifferentiation Any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation. go.json down regulation of transdifferentiation|down-regulation of transdifferentiation|downregulation of transdifferentiation|inhibition of transdifferentiation http://purl.obolibrary.org/obo/GO_1903619 GO:0048450 biolink:BiologicalProcess floral organ structural organization The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure. go.json floral organ structural organisation http://purl.obolibrary.org/obo/GO_0048450 GO:1903618 biolink:BiologicalProcess regulation of transdifferentiation Any process that modulates the frequency, rate or extent of transdifferentiation. go.json http://purl.obolibrary.org/obo/GO_1903618 GO:1903617 biolink:BiologicalProcess positive regulation of mitotic cytokinesis, division site positioning Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis, division site positioning. go.json positive regulation of mitotic cytokinesis, site selection http://purl.obolibrary.org/obo/GO_1903617 GO:1903616 biolink:BiologicalProcess obsolete MAPK cascade involved in axon regeneration OBSOLETE. Any MAPK cascade that is involved in axon regeneration. go.json ERK/MAPK cascade involved in axon regeneration|MAP kinase cascade involved in axon regeneration|MAP kinase kinase kinase cascade involved in axon regeneration|MAPK signal transduction involved in axon regeneration|MAPK signaling involved in axon regeneration|MAPK signalling involved in axon regeneration|MAPKKK cascade during sporulation involved in axon regeneration|MAPKKK cascade involved in axon regeneration|mitogen-activated protein kinase cascade involved in axon regeneration True http://purl.obolibrary.org/obo/GO_1903616 GO:1903615 biolink:BiologicalProcess positive regulation of protein tyrosine phosphatase activity Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity. go.json activation of PPT-phosphatase activity|activation of PTP-phosphatase activity|activation of PTPase activity|activation of [phosphotyrosine]protein phosphatase activity|activation of phosphoprotein phosphatase (phosphotyrosine) activity|activation of phosphotyrosine histone phosphatase activity|activation of phosphotyrosine phosphatase activity|activation of phosphotyrosine protein phosphatase activity|activation of phosphotyrosylprotein phosphatase activity|activation of protein phosphotyrosine phosphatase activity|activation of protein tyrosine phosphatase activity|activation of protein-tyrosine-phosphatase activity|activation of protein-tyrosine-phosphate phosphohydrolase activity|activation of tyrosine O-phosphate phosphatase activity|activation of tyrosylprotein phosphatase activity|positive regulation of PPT-phosphatase activity|positive regulation of PTP-phosphatase activity|positive regulation of PTPase activity|positive regulation of [phosphotyrosine]protein phosphatase activity|positive regulation of phosphoprotein phosphatase (phosphotyrosine) activity|positive regulation of phosphotyrosine histone phosphatase activity|positive regulation of phosphotyrosine phosphatase activity|positive regulation of phosphotyrosine protein phosphatase activity|positive regulation of phosphotyrosylprotein phosphatase activity|positive regulation of protein phosphotyrosine phosphatase activity|positive regulation of protein-tyrosine-phosphatase activity|positive regulation of protein-tyrosine-phosphate phosphohydrolase activity|positive regulation of tyrosine O-phosphate phosphatase activity|positive regulation of tyrosylprotein phosphatase activity|up regulation of PPT-phosphatase activity|up regulation of PTP-phosphatase activity|up regulation of PTPase activity|up regulation of [phosphotyrosine]protein phosphatase activity|up regulation of phosphoprotein phosphatase (phosphotyrosine) activity|up regulation of phosphotyrosine histone phosphatase activity|up regulation of phosphotyrosine phosphatase activity|up regulation of phosphotyrosine protein phosphatase activity|up regulation of phosphotyrosylprotein phosphatase activity|up regulation of protein phosphotyrosine phosphatase activity|up regulation of protein tyrosine phosphatase activity|up regulation of protein-tyrosine-phosphatase activity|up regulation of protein-tyrosine-phosphate phosphohydrolase activity|up regulation of tyrosine O-phosphate phosphatase activity|up regulation of tyrosylprotein phosphatase activity|up-regulation of PPT-phosphatase activity|up-regulation of PTP-phosphatase activity|up-regulation of PTPase activity|up-regulation of [phosphotyrosine]protein phosphatase activity|up-regulation of phosphoprotein phosphatase (phosphotyrosine) activity|up-regulation of phosphotyrosine histone phosphatase activity|up-regulation of phosphotyrosine phosphatase activity|up-regulation of phosphotyrosine protein phosphatase activity|up-regulation of phosphotyrosylprotein phosphatase activity|up-regulation of protein phosphotyrosine phosphatase activity|up-regulation of protein tyrosine phosphatase activity|up-regulation of protein-tyrosine-phosphatase activity|up-regulation of protein-tyrosine-phosphate phosphohydrolase activity|up-regulation of tyrosine O-phosphate phosphatase activity|up-regulation of tyrosylprotein phosphatase activity|upregulation of PPT-phosphatase activity|upregulation of PTP-phosphatase activity|upregulation of PTPase activity|upregulation of [phosphotyrosine]protein phosphatase activity|upregulation of phosphoprotein phosphatase (phosphotyrosine) activity|upregulation of phosphotyrosine histone phosphatase activity|upregulation of phosphotyrosine phosphatase activity|upregulation of phosphotyrosine protein phosphatase activity|upregulation of phosphotyrosylprotein phosphatase activity|upregulation of protein phosphotyrosine phosphatase activity|upregulation of protein tyrosine phosphatase activity|upregulation of protein-tyrosine-phosphatase activity|upregulation of protein-tyrosine-phosphate phosphohydrolase activity|upregulation of tyrosine O-phosphate phosphatase activity|upregulation of tyrosylprotein phosphatase activity http://purl.obolibrary.org/obo/GO_1903615 gocheck_do_not_annotate GO:1903614 biolink:BiologicalProcess negative regulation of protein tyrosine phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity. go.json down regulation of PPT-phosphatase activity|down regulation of PTP-phosphatase activity|down regulation of PTPase activity|down regulation of [phosphotyrosine]protein phosphatase activity|down regulation of phosphoprotein phosphatase (phosphotyrosine) activity|down regulation of phosphotyrosine histone phosphatase activity|down regulation of phosphotyrosine phosphatase activity|down regulation of phosphotyrosine protein phosphatase activity|down regulation of phosphotyrosylprotein phosphatase activity|down regulation of protein phosphotyrosine phosphatase activity|down regulation of protein tyrosine phosphatase activity|down regulation of protein-tyrosine-phosphatase activity|down regulation of protein-tyrosine-phosphate phosphohydrolase activity|down regulation of tyrosine O-phosphate phosphatase activity|down regulation of tyrosylprotein phosphatase activity|down-regulation of PPT-phosphatase activity|down-regulation of PTP-phosphatase activity|down-regulation of PTPase activity|down-regulation of [phosphotyrosine]protein phosphatase activity|down-regulation of phosphoprotein phosphatase (phosphotyrosine) activity|down-regulation of phosphotyrosine histone phosphatase activity|down-regulation of phosphotyrosine phosphatase activity|down-regulation of phosphotyrosine protein phosphatase activity|down-regulation of phosphotyrosylprotein phosphatase activity|down-regulation of protein phosphotyrosine phosphatase activity|down-regulation of protein tyrosine phosphatase activity|down-regulation of protein-tyrosine-phosphatase activity|down-regulation of protein-tyrosine-phosphate phosphohydrolase activity|down-regulation of tyrosine O-phosphate phosphatase activity|down-regulation of tyrosylprotein phosphatase activity|downregulation of PPT-phosphatase activity|downregulation of PTP-phosphatase activity|downregulation of PTPase activity|downregulation of [phosphotyrosine]protein phosphatase activity|downregulation of phosphoprotein phosphatase (phosphotyrosine) activity|downregulation of phosphotyrosine histone phosphatase activity|downregulation of phosphotyrosine phosphatase activity|downregulation of phosphotyrosine protein phosphatase activity|downregulation of phosphotyrosylprotein phosphatase activity|downregulation of protein phosphotyrosine phosphatase activity|downregulation of protein tyrosine phosphatase activity|downregulation of protein-tyrosine-phosphatase activity|downregulation of protein-tyrosine-phosphate phosphohydrolase activity|downregulation of tyrosine O-phosphate phosphatase activity|downregulation of tyrosylprotein phosphatase activity|inhibition of PPT-phosphatase activity|inhibition of PTP-phosphatase activity|inhibition of PTPase activity|inhibition of [phosphotyrosine]protein phosphatase activity|inhibition of phosphoprotein phosphatase (phosphotyrosine) activity|inhibition of phosphotyrosine histone phosphatase activity|inhibition of phosphotyrosine phosphatase activity|inhibition of phosphotyrosine protein phosphatase activity|inhibition of phosphotyrosylprotein phosphatase activity|inhibition of protein phosphotyrosine phosphatase activity|inhibition of protein tyrosine phosphatase activity|inhibition of protein-tyrosine-phosphatase activity|inhibition of protein-tyrosine-phosphate phosphohydrolase activity|inhibition of tyrosine O-phosphate phosphatase activity|inhibition of tyrosylprotein phosphatase activity|negative regulation of PPT-phosphatase activity|negative regulation of PTP-phosphatase activity|negative regulation of PTPase activity|negative regulation of [phosphotyrosine]protein phosphatase activity|negative regulation of phosphoprotein phosphatase (phosphotyrosine) activity|negative regulation of phosphotyrosine histone phosphatase activity|negative regulation of phosphotyrosine phosphatase activity|negative regulation of phosphotyrosine protein phosphatase activity|negative regulation of phosphotyrosylprotein phosphatase activity|negative regulation of protein phosphotyrosine phosphatase activity|negative regulation of protein-tyrosine-phosphatase activity|negative regulation of protein-tyrosine-phosphate phosphohydrolase activity|negative regulation of tyrosine O-phosphate phosphatase activity|negative regulation of tyrosylprotein phosphatase activity http://purl.obolibrary.org/obo/GO_1903614 gocheck_do_not_annotate GO:1903613 biolink:BiologicalProcess regulation of protein tyrosine phosphatase activity Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity. go.json regulation of PPT-phosphatase activity|regulation of PTP-phosphatase activity|regulation of PTPase activity|regulation of [phosphotyrosine]protein phosphatase activity|regulation of phosphoprotein phosphatase (phosphotyrosine) activity|regulation of phosphotyrosine histone phosphatase activity|regulation of phosphotyrosine phosphatase activity|regulation of phosphotyrosine protein phosphatase activity|regulation of phosphotyrosylprotein phosphatase activity|regulation of protein phosphotyrosine phosphatase activity|regulation of protein-tyrosine-phosphatase activity|regulation of protein-tyrosine-phosphate phosphohydrolase activity|regulation of tyrosine O-phosphate phosphatase activity|regulation of tyrosylprotein phosphatase activity http://purl.obolibrary.org/obo/GO_1903613 gocheck_do_not_annotate GO:0048459 biolink:BiologicalProcess floral whorl structural organization The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure. go.json floral whorl structural organisation http://purl.obolibrary.org/obo/GO_0048459 GO:1903612 biolink:BiologicalProcess positive regulation of calcium-dependent ATPase activity Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity. go.json activation of calcium-dependent ATPase activity|up regulation of calcium-dependent ATPase activity|up-regulation of calcium-dependent ATPase activity|upregulation of calcium-dependent ATPase activity http://purl.obolibrary.org/obo/GO_1903612 gocheck_do_not_annotate GO:1903611 biolink:BiologicalProcess negative regulation of calcium-dependent ATPase activity Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity. go.json down regulation of calcium-dependent ATPase activity|down-regulation of calcium-dependent ATPase activity|downregulation of calcium-dependent ATPase activity|inhibition of calcium-dependent ATPase activity http://purl.obolibrary.org/obo/GO_1903611 gocheck_do_not_annotate GO:0048458 biolink:BiologicalProcess floral whorl formation The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048458 GO:1903610 biolink:BiologicalProcess regulation of calcium-dependent ATPase activity Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity. go.json http://purl.obolibrary.org/obo/GO_1903610 gocheck_do_not_annotate GO:0048457 biolink:BiologicalProcess floral whorl morphogenesis The process in which the anatomical structures of the floral whorl are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048457 GO:0048456 biolink:BiologicalProcess stamen structural organization The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure. go.json stamen structural organisation http://purl.obolibrary.org/obo/GO_0048456 GO:0048455 biolink:BiologicalProcess stamen formation The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0048455 GO:0048454 biolink:BiologicalProcess sepal structural organization The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure. go.json sepal structural organisation http://purl.obolibrary.org/obo/GO_0048454 GO:0048604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048604 GO:0048603 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048603 GO:0048602 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048602 GO:0048601 biolink:BiologicalProcess oocyte morphogenesis The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. go.json oocyte morphogenesis during differentiation http://purl.obolibrary.org/obo/GO_0048601 GO:0048600 biolink:BiologicalProcess oocyte fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte. go.json http://purl.obolibrary.org/obo/GO_0048600 GO:0048609 biolink:BiologicalProcess multicellular organismal reproductive process The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. go.json organismal reproductive process|reproductive process in a multicellular organism http://purl.obolibrary.org/obo/GO_0048609 GO:0048608 biolink:BiologicalProcess reproductive structure development The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. go.json http://purl.obolibrary.org/obo/GO_0048608 GO:0048607 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048607 GO:0048606 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048606 GO:0048605 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048605 GO:0048615 biolink:BiologicalProcess embryonic anterior midgut (ectodermal) morphogenesis The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase. go.json http://purl.obolibrary.org/obo/GO_0048615 GO:0048614 biolink:BiologicalProcess post-embryonic ectodermal digestive tract morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. go.json post-embryonic ectodermal gut morphogenesis http://purl.obolibrary.org/obo/GO_0048614 GO:0048613 biolink:BiologicalProcess embryonic ectodermal digestive tract morphogenesis The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized. go.json embryonic ectodermal gut morphogenesis http://purl.obolibrary.org/obo/GO_0048613 GO:0048612 biolink:BiologicalProcess post-embryonic ectodermal digestive tract development The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. go.json post-embryonic ectodermal gut development http://purl.obolibrary.org/obo/GO_0048612 GO:0048611 biolink:BiologicalProcess embryonic ectodermal digestive tract development The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. go.json embryonic ectodermal gut development http://purl.obolibrary.org/obo/GO_0048611 GO:0048610 biolink:BiologicalProcess obsolete cellular process involved in reproduction OBSOLETE. A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism. go.json cellular process involved in reproduction|reproductive cellular process True http://purl.obolibrary.org/obo/GO_0048610 GO:0048619 biolink:BiologicalProcess embryonic hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase. go.json http://purl.obolibrary.org/obo/GO_0048619 GO:0048618 biolink:BiologicalProcess post-embryonic foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase. go.json http://purl.obolibrary.org/obo/GO_0048618 GO:0048617 biolink:BiologicalProcess embryonic foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase. go.json http://purl.obolibrary.org/obo/GO_0048617 GO:0048616 biolink:BiologicalProcess post-embryonic anterior midgut (ectodermal) morphogenesis The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase. go.json http://purl.obolibrary.org/obo/GO_0048616 GO:0097596 biolink:CellularComponent ventral disc supernumerary microtubule array A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage). go.json supernumerary microtubule array|ventral disk supernumerary microtubule array http://purl.obolibrary.org/obo/GO_0097596 GO:0097595 biolink:CellularComponent ventral disc crossbridge Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet. go.json crossbridge|ventral disk crossbridge http://purl.obolibrary.org/obo/GO_0097595 GO:0097598 biolink:CellularComponent sperm cytoplasmic droplet A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted. go.json sperm residual cytoplasm http://purl.obolibrary.org/obo/GO_0097598 GO:0097597 biolink:CellularComponent ventral disc Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence. go.json adhesive disc|ventral adhesive disc|ventral disk http://purl.obolibrary.org/obo/GO_0097597 GO:0097592 biolink:CellularComponent ventral disc overlap zone A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself). go.json overlap zone|ventral disk overlap zone http://purl.obolibrary.org/obo/GO_0097592 GO:0097591 biolink:CellularComponent ventral disc lateral crest Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet. go.json lateral crest|ventral disk lateral crest http://purl.obolibrary.org/obo/GO_0097591 GO:0097594 biolink:CellularComponent ventral disc dorsal microribbon Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons. go.json dorsal microribbon|dorsal ribbon|microribbon|ventral disk dorsal microribbon http://purl.obolibrary.org/obo/GO_0097594 GO:0009019 biolink:MolecularActivity obsolete tRNA (guanine-N1-)-methyltransferase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. Reactome:R-HSA-6782859|Reactome:R-HSA-6786621|Reactome:R-HSA-6787591 go.json S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity|tRNA guanine 1-methyltransferase activity|transfer ribonucleate guanine 1-methyltransferase activity True http://purl.obolibrary.org/obo/GO_0009019 GO:0097593 biolink:CellularComponent ventral disc microtubule array A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane. go.json spiral microtubule array|ventral disc spiral microtubule array|ventral disk microtubule array http://purl.obolibrary.org/obo/GO_0097593 GO:0010007 biolink:CellularComponent magnesium chelatase complex A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner. go.json http://purl.obolibrary.org/obo/GO_0010007 GO:0009018 biolink:MolecularActivity sucrose phosphorylase activity Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate. EC:2.4.1.7|MetaCyc:SUCROSE-PHOSPHORYLASE-RXN|RHEA:24048 go.json disaccharide glucosyltransferase activity|sucrose glucosyltransferase activity|sucrose:phosphate alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0009018 GO:0009017 biolink:MolecularActivity succinylglutamate desuccinylase activity Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate. EC:3.5.1.96|KEGG_REACTION:R00411|MetaCyc:SUCCGLUDESUCC-RXN|RHEA:15169 go.json AstE|N-succinyl-L-glutamate amidohydrolase activity|N2-succinylglutamate desuccinylase activity|SGDS http://purl.obolibrary.org/obo/GO_0009017 GO:0010006 biolink:CellularComponent Toc complex Protein translocon complex at the chloroplast outer membrane. go.json http://purl.obolibrary.org/obo/GO_0010006 GO:0097590 biolink:BiologicalProcess archaeal-type flagellum-dependent cell motility Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel. go.json archaeal-type flagellar cell motility http://purl.obolibrary.org/obo/GO_0097590 GO:0009016 biolink:MolecularActivity succinyldiaminopimelate transaminase activity Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate. EC:2.6.1.17|KEGG_REACTION:R04475|MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN|RHEA:11960 go.json N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity|N-succinyl-L-diaminopimelic glutamic transaminase activity|succinyldiaminopimelate aminotransferase activity|succinyldiaminopimelate transferase activity http://purl.obolibrary.org/obo/GO_0009016 GO:0010009 biolink:CellularComponent cytoplasmic side of endosome membrane The side (leaflet) of the endosome membrane that faces the cytoplasm. go.json external leaflet of endosome membrane|external side of endosome membrane http://purl.obolibrary.org/obo/GO_0010009 GO:0009015 biolink:MolecularActivity N-succinylarginine dihydrolase activity Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. EC:3.5.3.23|KEGG_REACTION:R04189|MetaCyc:SUCCARGDIHYDRO-RXN|RHEA:19533 go.json 2-N-succinyl-L-arginine iminohydrolase (decarboxylating)|AruB|AstB|N2-succinyl-L-arginine iminohydrolase (decarboxylating)|N2-succinylarginine dihydrolase activity|SADH|arginine succinylhydrolase activity|succinylarginine dihydrolase activity http://purl.obolibrary.org/obo/GO_0009015 GO:0010008 biolink:CellularComponent endosome membrane The lipid bilayer surrounding an endosome. NIF_Subcellular:sao978443756 go.json endosomal membrane http://purl.obolibrary.org/obo/GO_0010008 GO:0009014 biolink:MolecularActivity succinyl-diaminopimelate desuccinylase activity Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. EC:3.5.1.18|KEGG_REACTION:R02734|MetaCyc:SUCCDIAMINOPIMDESUCC-RXN|RHEA:22608 go.json N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity|N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0009014 GO:0009013 biolink:MolecularActivity succinate-semialdehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. EC:1.2.1.16|UM-BBD_reactionID:r0371 go.json succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))|succinate-semialdehyde:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0009013 GO:0009012 biolink:MolecularActivity aminoglycoside 3''-adenylyltransferase activity Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+. EC:2.7.7.47|KEGG_REACTION:R02226|MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN|RHEA:20245 go.json AAD (3'')|ATP:streptomycin 3''-adenylyltransferase activity|streptomycin 3''-adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0009012 GO:0009011 biolink:MolecularActivity starch synthase activity Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). EC:2.4.1.21|MetaCyc:GLYCOGENSYN-RXN go.json ADP-glucose starch synthase activity|ADP-glucose transglucosylase activity|ADP-glucose--starch glucosyltransferase activity|ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|ADPG starch synthetase activity|ADPG-starch glucosyltransferase activity|ADPglucose-starch glucosyltransferase activity|ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|adenosine diphosphate glucose-starch glucosyltransferase activity|adenosine diphosphoglucose-starch glucosyltransferase activity|glycogen synthase activity|starch (bacterial glycogen) synthase activity|starch synthetase activity http://purl.obolibrary.org/obo/GO_0009011 GO:0009021 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009021 GO:0009020 biolink:MolecularActivity obsolete tRNA (guanosine-2'-O-)-methyltransferase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine. Reactome:R-HSA-9024161|https://github.com/geneontology/go-ontology/issues/26085 go.json True http://purl.obolibrary.org/obo/GO_0009020 GO:0010001 biolink:BiologicalProcess glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. go.json glia cell differentiation|neuroglia differentiation http://purl.obolibrary.org/obo/GO_0010001 GO:0010000 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010000 GO:0010003 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010003 GO:0010002 biolink:BiologicalProcess cardioblast differentiation The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json cardiac precursor cell differentiation|cardioblast cell differentiation|cardiomyocyte generation http://purl.obolibrary.org/obo/GO_0010002 GO:0010005 biolink:CellularComponent cortical microtubule, transverse to long axis Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition. go.json http://purl.obolibrary.org/obo/GO_0010005 GO:0010004 biolink:BiologicalProcess gastrulation involving germ band extension A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0010004 GO:0097599 biolink:MolecularActivity xylanase activity Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues. go.json xylosidase activity http://purl.obolibrary.org/obo/GO_0097599 GO:0009029 biolink:MolecularActivity tetraacyldisaccharide 4'-kinase activity Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H+ + lipid IV(a). EC:2.7.1.130|KEGG_REACTION:R04657|MetaCyc:TETRAACYLDISACC4KIN-RXN|RHEA:20700 go.json ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity|lipid-A 4'-kinase activity http://purl.obolibrary.org/obo/GO_0009029 GO:0010018 biolink:BiologicalProcess far-red light signaling pathway The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json far red light signalling pathway|far red signaling pathway|far-red light signal transduction http://purl.obolibrary.org/obo/GO_0010018 GO:0009028 biolink:MolecularActivity tartronate-semialdehyde synthase activity Catalysis of the reaction: 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2. EC:4.1.1.47|KEGG_REACTION:R00013|MetaCyc:GLYOCARBOLIG-RXN|RHEA:10136 go.json glyoxalate carboligase activity|glyoxylate carbo-ligase activity|glyoxylate carboligase activity|glyoxylate carboxy-lyase (dimerizing)|glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)|glyoxylic carbo-ligase activity|hydroxymalonic semialdehyde carboxylase activity|tartronate semialdehyde carboxylase activity|tartronic semialdehyde carboxylase activity http://purl.obolibrary.org/obo/GO_0009028 GO:0010017 biolink:BiologicalProcess red or far-red light signaling pathway The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json phytochrome signaling pathway|red or far red light signaling pathway|red or far-red light signal transduction|red or far-red light signalling pathway|red/far red light signaling pathway http://purl.obolibrary.org/obo/GO_0010017 GO:0009027 biolink:MolecularActivity tartrate dehydrogenase activity Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+. EC:1.1.1.93|MetaCyc:TARTRATE-DEHYDROGENASE-RXN|RHEA:15209 go.json mesotartrate dehydrogenase activity|tartrate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0009027 GO:0010019 biolink:BiologicalProcess chloroplast-nucleus signaling pathway The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis. go.json chloroplast-nucleus signalling pathway http://purl.obolibrary.org/obo/GO_0010019 GO:0009026 biolink:MolecularActivity tagaturonate reductase activity Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH. EC:1.1.1.58|KEGG_REACTION:R02555|MetaCyc:ALTRO-OXIDOREDUCT-RXN|RHEA:17813 go.json D-altronate:NAD+ 3-oxidoreductase activity|D-tagaturonate reductase activity|TagUAR|altronate dehydrogenase activity|altronate oxidoreductase activity|altronic oxidoreductase activity|tagaturonate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0009026 GO:0009025 biolink:MolecularActivity tagatose-bisphosphate aldolase activity Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate. EC:4.1.2.40|KEGG_REACTION:R01069|MetaCyc:TAGAALDOL-RXN|RHEA:22948 go.json AgaY|AgaZ|D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)|D-tagatose-1,6-bisphosphate aldolase activity|D-tagatose-1,6-bisphosphate triosephosphate lyase activity|KbaY|tagatose 1,6-diphosphate aldolase activity|tagatose-1,6-bisphosphate aldolase 1 http://purl.obolibrary.org/obo/GO_0009025 GO:0009024 biolink:MolecularActivity tagatose-6-phosphate kinase activity Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. EC:2.7.1.144|MetaCyc:TAGAKIN-RXN|RHEA:12420 go.json ATP:D-tagatose-6-phosphate 1-phosphotransferase activity|phosphotagatokinase activity http://purl.obolibrary.org/obo/GO_0009024 GO:0009023 biolink:MolecularActivity obsolete tRNA sulfurtransferase OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide. go.json tRNA sulfurtransferase|tRNA sulphurtransferase activity True http://purl.obolibrary.org/obo/GO_0009023 GO:0009022 biolink:MolecularActivity tRNA nucleotidyltransferase activity Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. EC:2.7.7.56|MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN|RHEA:10628 go.json RNase PH activity|phosphate-dependent exonuclease activity|ribonuclease PH activity http://purl.obolibrary.org/obo/GO_0009022 GO:0010010 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010010 GO:0009032 biolink:MolecularActivity thymidine phosphorylase activity Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. EC:2.4.2.4|MetaCyc:THYM-PHOSPH-RXN|RHEA:16037 go.json pyrimidine phosphorylase activity|thymidine-orthophosphate deoxyribosyltransferase activity|thymidine:phosphate deoxy-D-ribosyltransferase activity|thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0009032 GO:0009031 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009031 GO:0009030 biolink:MolecularActivity thiamine-phosphate kinase activity Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate. EC:2.7.4.16|KEGG_REACTION:R00617|MetaCyc:THI-P-KIN-RXN|RHEA:15913 go.json ATP:thiamine-phosphate phosphotransferase activity|thiamin monophosphatase activity|thiamin monophosphokinase activity|thiamin phosphate kinase activity|thiamin-monophosphate kinase activity|thiamin-phosphate kinase activity|thiamine-monophosphate kinase activity http://purl.obolibrary.org/obo/GO_0009030 GO:0010012 biolink:MolecularActivity steroid 22-alpha hydroxylase activity Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O. go.json http://purl.obolibrary.org/obo/GO_0010012 GO:0010011 biolink:MolecularActivity auxin binding Binding to auxin, a plant hormone that regulates aspects of plant growth. go.json auxin receptor http://purl.obolibrary.org/obo/GO_0010011 GO:0010014 biolink:BiologicalProcess meristem initiation Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. go.json http://purl.obolibrary.org/obo/GO_0010014 GO:0010013 biolink:MolecularActivity N-1-naphthylphthalamic acid binding Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor. go.json http://purl.obolibrary.org/obo/GO_0010013 GO:0010016 biolink:BiologicalProcess shoot system morphogenesis The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground. go.json shoot morphogenesis http://purl.obolibrary.org/obo/GO_0010016 GO:0010015 biolink:BiologicalProcess root morphogenesis The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support. go.json http://purl.obolibrary.org/obo/GO_0010015 GO:0097574 biolink:CellularComponent lateral part of cell The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells. go.json http://purl.obolibrary.org/obo/GO_0097574 GO:0097573 biolink:MolecularActivity obsolete glutathione oxidoreductase activity OBSOLETE. Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione. go.json True http://purl.obolibrary.org/obo/GO_0097573 GO:0097576 biolink:BiologicalProcess vacuole fusion Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. go.json http://purl.obolibrary.org/obo/GO_0097576 GO:0097575 biolink:CellularComponent lateral cell cortex The region directly beneath the plasma membrane of the lateral portion of the cell. go.json http://purl.obolibrary.org/obo/GO_0097575 GO:0097570 biolink:CellularComponent cyst wall The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins. go.json http://purl.obolibrary.org/obo/GO_0097570 GO:0097572 biolink:CellularComponent right nucleus One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side. go.json http://purl.obolibrary.org/obo/GO_0097572 GO:0097571 biolink:CellularComponent left nucleus One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side. go.json http://purl.obolibrary.org/obo/GO_0097571 GO:0097578 biolink:BiologicalProcess sequestering of copper ion The process of binding or confining copper ions such that they are separated from other components of a biological system. go.json copper ion retention|copper ion sequestering|copper ion sequestration|copper ion storage|retention of copper ion|sequestration of copper ion|storage of copper ion http://purl.obolibrary.org/obo/GO_0097578 GO:0097577 biolink:BiologicalProcess sequestering of iron ion The process of binding or confining iron ions such that they are separated from other components of a biological system. go.json iron ion retention|iron ion sequestering|iron ion sequestration|iron ion storage|retention of iron ion|sequestration of iron ion|storage of iron ion http://purl.obolibrary.org/obo/GO_0097577 GO:0097579 biolink:BiologicalProcess extracellular sequestering of copper ion The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system. go.json extracellular copper ion retention|extracellular copper ion sequestering|extracellular copper ion sequestration|extracellular copper ion storage|extracellular retention of copper ion|extracellular sequestration of copper ion|extracellular storage of copper ion http://purl.obolibrary.org/obo/GO_0097579 GO:0097585 biolink:CellularComponent dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p. go.json Pmt5p-Pmt3p complex http://purl.obolibrary.org/obo/GO_0097585 GO:0097584 biolink:CellularComponent dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p. go.json Pmt5p-Pmt2p complex http://purl.obolibrary.org/obo/GO_0097584 GO:0097587 biolink:CellularComponent MutLgamma complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3. go.json http://purl.obolibrary.org/obo/GO_0097587 GO:0097586 biolink:CellularComponent dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p. go.json Pmt4p-Pmt4p complex|dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer|dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex http://purl.obolibrary.org/obo/GO_0097586 GO:0097581 biolink:BiologicalProcess lamellipodium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. go.json http://purl.obolibrary.org/obo/GO_0097581 GO:0097580 biolink:BiologicalProcess intracellular sequestering of copper ion The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system. go.json intracellular copper ion retention|intracellular copper ion sequestering|intracellular copper ion sequestration|intracellular copper ion storage|intracellular retention of copper ion|intracellular sequestration of copper ion|intracellular storage of copper ion http://purl.obolibrary.org/obo/GO_0097580 GO:0097583 biolink:CellularComponent dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p. go.json Pmt1p-Pmt3p complex http://purl.obolibrary.org/obo/GO_0097583 GO:0009009 biolink:MolecularActivity site-specific recombinase activity Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. go.json RecA-family recombinase activity http://purl.obolibrary.org/obo/GO_0009009 goslim_pir GO:0097582 biolink:CellularComponent dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p. go.json Pmt1p-Pmt2p complex http://purl.obolibrary.org/obo/GO_0097582 GO:0009008 biolink:MolecularActivity DNA-methyltransferase activity Catalysis of the transfer of a methyl group to a DNA molecule. Reactome:R-HSA-5227490 go.json DNA methylase|DNA methyltransferase activity|DNA transmethylase activity|Type II DNA methylase|deoxyribonucleate methylase activity|deoxyribonucleate methyltransferase activity|deoxyribonucleic acid methylase activity|deoxyribonucleic acid methyltransferase activity|deoxyribonucleic acid modification methylase activity http://purl.obolibrary.org/obo/GO_0009008 GO:0009007 biolink:MolecularActivity site-specific DNA-methyltransferase (adenine-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. EC:2.1.1.72|MetaCyc:2.1.1.72-RXN|RHEA:15197 go.json DNA adenine methylase|EcoRI methylase|N-6 adenine-specific DNA methylase activity|modification methylase activity|restriction-modification system activity http://purl.obolibrary.org/obo/GO_0009007 GO:0009006 biolink:MolecularActivity obsolete siroheme synthase activity OBSOLETE. (Was not defined before being made obsolete). go.json sirohaem synthase activity|siroheme synthase activity True http://purl.obolibrary.org/obo/GO_0009006 GO:0009005 biolink:MolecularActivity obsolete signal peptidase II activity OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group. go.json SPase II activity|leader peptidase II|lipoprotein signal peptidase activity|premurein leader proteinase activity|premurein-leader peptidase activity|prolipoprotein signal peptidase activity|prolipoprotein-signal peptidase activity|signal peptidase II activity True http://purl.obolibrary.org/obo/GO_0009005 GO:0009004 biolink:MolecularActivity obsolete signal peptidase I activity OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor. go.json Escherichia coli leader peptidase|HOSP|PuIO prepilin peptidase|SPC|SPase I activity|bacterial leader peptidase 1|bacterial leader peptidase I activity|eukaryotic signal peptidase|eukaryotic signal proteinase|leader peptidase I|leader peptidase activity|leader peptide hydrolase activity|leader proteinase activity|phage-procoat-leader peptidase activity|pilin leader peptidase|prokaryotic leader peptidase|prokaryotic signal peptidase|prokaryotic signal proteinase|propeptidase activity|signal peptidase I activity|signal peptide hydrolase activity|signal proteinase activity|signalase activity True http://purl.obolibrary.org/obo/GO_0009004 GO:0009003 biolink:MolecularActivity obsolete signal peptidase activity OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor. go.json signal peptidase activity True http://purl.obolibrary.org/obo/GO_0009003 GO:0009002 biolink:MolecularActivity serine-type D-Ala-D-Ala carboxypeptidase activity Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. EC:3.4.16.4|MetaCyc:3.4.16.4-RXN go.json D-alanine carboxypeptidase|D-alanyl carboxypeptidase activity|D-alanyl-D-alanine carboxypeptidase activity|D-alanyl-D-alanine-carboxypeptidase activity|D-alanyl-D-alanine-cleaving peptidase activity|D-alanyl-D-alanine-cleaving-peptidase activity|DD-carboxypeptidase|DD-peptidase activity|DD-transpeptidase activity http://purl.obolibrary.org/obo/GO_0009002 GO:0009001 biolink:MolecularActivity serine O-acetyltransferase activity Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. EC:2.3.1.30|KEGG_REACTION:R00586|MetaCyc:SERINE-O-ACETTRAN-RXN|RHEA:24560 go.json L-serine acetyltransferase activity|SATase activity|acetyl-CoA:L-serine O-acetyltransferase activity|serine acetyltransferase activity|serine transacetylase activity http://purl.obolibrary.org/obo/GO_0009001 GO:0009000 biolink:MolecularActivity selenocysteine lyase activity Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor. EC:4.4.1.16|MetaCyc:SELENOCYSTEINE-LYASE-RXN|RHEA:11632|Reactome:R-HSA-2408524 go.json L-selenocysteine selenide-lyase (L-alanine-forming)|selenocysteine beta-lyase activity|selenocysteine reductase activity http://purl.obolibrary.org/obo/GO_0009000 GO:0009010 biolink:MolecularActivity sorbitol-6-phosphate 2-dehydrogenase activity Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. EC:1.1.1.140|MetaCyc:SORB6PDEHYDROG-RXN|RHEA:19837 go.json D-glucitol-6-phosphate dehydrogenase activity|D-sorbitol 6-phosphate dehydrogenase activity|D-sorbitol-6-phosphate dehydrogenase activity|D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity|glucitol-6-phosphate dehydrogenase activity|ketosephosphate reductase activity|sorbitol-6-P-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0009010 GO:0097589 biolink:CellularComponent archaeal-type flagellum A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function. go.json archaeal flagellum|archaella|archaellum http://purl.obolibrary.org/obo/GO_0097589 GO:0097588 biolink:BiologicalProcess archaeal or bacterial-type flagellum-dependent cell motility Cell motility due to movement of bacterial- or archaeal-type flagella. go.json http://purl.obolibrary.org/obo/GO_0097588 GO:0048585 biolink:BiologicalProcess negative regulation of response to stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. go.json down regulation of response to stimulus|down-regulation of response to stimulus|downregulation of response to stimulus|inhibition of response to stimulus http://purl.obolibrary.org/obo/GO_0048585 gocheck_do_not_manually_annotate GO:0048584 biolink:BiologicalProcess positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. go.json activation of response to stimulus|stimulation of response to stimulus|up regulation of response to stimulus|up-regulation of response to stimulus|upregulation of response to stimulus http://purl.obolibrary.org/obo/GO_0048584 gocheck_do_not_manually_annotate GO:0048583 biolink:BiologicalProcess regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. go.json http://purl.obolibrary.org/obo/GO_0048583 gocheck_do_not_manually_annotate GO:0097510 biolink:BiologicalProcess base-excision repair, AP site formation via deaminated base removal A base-excision repair, AP site formation process occurring via excision of a deaminated base. go.json http://purl.obolibrary.org/obo/GO_0097510 GO:0048582 biolink:BiologicalProcess positive regulation of post-embryonic development Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. go.json activation of post-embryonic development|stimulation of post-embryonic development|up regulation of post-embryonic development|up-regulation of post-embryonic development|upregulation of post-embryonic development http://purl.obolibrary.org/obo/GO_0048582 GO:0048581 biolink:BiologicalProcess negative regulation of post-embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. go.json down regulation of post-embryonic development|down-regulation of post-embryonic development|downregulation of post-embryonic development|inhibition of post-embryonic development http://purl.obolibrary.org/obo/GO_0048581 GO:0048580 biolink:BiologicalProcess regulation of post-embryonic development Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048580 GO:1903989 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903989 GO:1903988 biolink:BiologicalProcess iron ion export across plasma membrane The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json ferrous iron export|ferrous iron export across plasma membrane|iron cation export|iron(2+) export http://purl.obolibrary.org/obo/GO_1903988 GO:1903985 biolink:BiologicalProcess regulation of intestinal D-glucose absorption Any process that modulates the frequency, rate or extent of intestinal D-glucose absorption. go.json http://purl.obolibrary.org/obo/GO_1903985 GO:1903984 biolink:BiologicalProcess positive regulation of TRAIL-activated apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. go.json activation of TRAIL-activated apoptotic signaling pathway|activation of TRAIL-activated extrinsic apoptotic signaling pathway|activation of TRAIL-induced apoptotic signaling pathway|activation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|positive regulation of TRAIL-activated extrinsic apoptotic signaling pathway|positive regulation of TRAIL-induced apoptotic signaling pathway|positive regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|up regulation of TRAIL-activated apoptotic signaling pathway|up regulation of TRAIL-activated extrinsic apoptotic signaling pathway|up regulation of TRAIL-induced apoptotic signaling pathway|up regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|up-regulation of TRAIL-activated apoptotic signaling pathway|up-regulation of TRAIL-activated extrinsic apoptotic signaling pathway|up-regulation of TRAIL-induced apoptotic signaling pathway|up-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|upregulation of TRAIL-activated apoptotic signaling pathway|upregulation of TRAIL-activated extrinsic apoptotic signaling pathway|upregulation of TRAIL-induced apoptotic signaling pathway|upregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_1903984 GO:0048589 biolink:BiologicalProcess developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. go.json http://purl.obolibrary.org/obo/GO_0048589 GO:0048588 biolink:BiologicalProcess developmental cell growth The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. go.json developmental growth of a unicellular organism http://purl.obolibrary.org/obo/GO_0048588 GO:1903983 biolink:BiologicalProcess positive regulation of microvillus length A process that increases the length of a microvillus. go.json activation of regulation of microvillus length|up regulation of regulation of microvillus length|up-regulation of regulation of microvillus length|upregulation of regulation of microvillus length http://purl.obolibrary.org/obo/GO_1903983 GO:0048587 biolink:BiologicalProcess regulation of short-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. go.json http://purl.obolibrary.org/obo/GO_0048587 GO:1903982 biolink:BiologicalProcess negative regulation of microvillus length A process that decreases the length of a microvillus. go.json down regulation of regulation of microvillus length|down-regulation of regulation of microvillus length|downregulation of regulation of microvillus length|inhibition of regulation of microvillus length http://purl.obolibrary.org/obo/GO_1903982 GO:1903981 biolink:MolecularActivity enterobactin binding Binding to enterobactin. go.json enterochelin binding|siderophore binding http://purl.obolibrary.org/obo/GO_1903981 GO:0048586 biolink:BiologicalProcess regulation of long-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. go.json http://purl.obolibrary.org/obo/GO_0048586 GO:1903991 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903991 GO:1903990 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903990 GO:0097519 biolink:CellularComponent DNA recombinase complex A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0097519 GO:0097516 biolink:CellularComponent microvillar actin bundle A parallel bundle of actin filaments at the core of a microvillus. go.json http://purl.obolibrary.org/obo/GO_0097516 GO:0097515 biolink:CellularComponent asexual spore wall A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species. go.json http://purl.obolibrary.org/obo/GO_0097515 GO:0097518 biolink:CellularComponent parallel actin filament bundle An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. go.json http://purl.obolibrary.org/obo/GO_0097518 GO:0097517 biolink:CellularComponent contractile actin filament bundle An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. go.json http://purl.obolibrary.org/obo/GO_0097517 GO:0097512 biolink:CellularComponent cardiac myofibril A cardiac myofibril is a myofibril specific to cardiac muscle cells. go.json http://purl.obolibrary.org/obo/GO_0097512 GO:0097511 biolink:CellularComponent dendritic cell dendrite A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. go.json http://purl.obolibrary.org/obo/GO_0097511 GO:0097514 biolink:CellularComponent sexual spore wall A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis. go.json http://purl.obolibrary.org/obo/GO_0097514 GO:0097513 biolink:CellularComponent myosin II filament A bipolar filament composed of myosin II molecules. go.json http://purl.obolibrary.org/obo/GO_0097513 GO:0048596 biolink:BiologicalProcess embryonic camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized during embryonic development. go.json embryonic eye morphogenesis http://purl.obolibrary.org/obo/GO_0048596 GO:0048595 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048595 GO:0048594 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048594 GO:0097521 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097521 GO:0097520 biolink:CellularComponent nucleotide-excision repair, preincision complex A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. go.json UvrA(2)-UvrB(2) complex|UvrA(2)B(2) complex|UvrB dimer http://purl.obolibrary.org/obo/GO_0097520 GO:0048593 biolink:BiologicalProcess camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. go.json camera-style eye morphogenesis http://purl.obolibrary.org/obo/GO_0048593 GO:0048592 biolink:BiologicalProcess eye morphogenesis The process in which the anatomical structures of the eye are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048592 GO:0048591 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048591 GO:0048590 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048590 GO:1903999 biolink:BiologicalProcess negative regulation of eating behavior Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior. go.json down regulation of eating behavior|down regulation of eating behaviour|down-regulation of eating behavior|down-regulation of eating behaviour|downregulation of eating behavior|downregulation of eating behaviour|inhibition of eating behavior|inhibition of eating behaviour|negative regulation of eating behaviour http://purl.obolibrary.org/obo/GO_1903999 GO:1903998 biolink:BiologicalProcess regulation of eating behavior Any process that modulates the frequency, rate or extent of eating behavior. go.json regulation of eating behaviour http://purl.obolibrary.org/obo/GO_1903998 GO:1903997 biolink:BiologicalProcess positive regulation of non-membrane spanning protein tyrosine kinase activity Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. go.json activation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|activation of Bruton's tyrosine kinase activity|activation of cytoplasmic protein tyrosine kinase activity|activation of focal adhesion kinase activity|activation of janus kinase 1 activity|activation of janus kinase 2 activity|activation of janus kinase 3 activity|activation of non-membrane spanning protein tyrosine kinase activity|activation of non-specific protein-tyrosine kinase activity|activation of p60c-src protein tyrosine kinase activity|positive regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|positive regulation of Bruton's tyrosine kinase activity|positive regulation of cytoplasmic protein tyrosine kinase activity|positive regulation of focal adhesion kinase activity|positive regulation of janus kinase 1 activity|positive regulation of janus kinase 2 activity|positive regulation of janus kinase 3 activity|positive regulation of non-specific protein-tyrosine kinase activity|positive regulation of p60c-src protein tyrosine kinase activity|up regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|up regulation of Bruton's tyrosine kinase activity|up regulation of cytoplasmic protein tyrosine kinase activity|up regulation of focal adhesion kinase activity|up regulation of janus kinase 1 activity|up regulation of janus kinase 2 activity|up regulation of janus kinase 3 activity|up regulation of non-membrane spanning protein tyrosine kinase activity|up regulation of non-specific protein-tyrosine kinase activity|up regulation of p60c-src protein tyrosine kinase activity|up-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|up-regulation of Bruton's tyrosine kinase activity|up-regulation of cytoplasmic protein tyrosine kinase activity|up-regulation of focal adhesion kinase activity|up-regulation of janus kinase 1 activity|up-regulation of janus kinase 2 activity|up-regulation of janus kinase 3 activity|up-regulation of non-membrane spanning protein tyrosine kinase activity|up-regulation of non-specific protein-tyrosine kinase activity|up-regulation of p60c-src protein tyrosine kinase activity|upregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|upregulation of Bruton's tyrosine kinase activity|upregulation of cytoplasmic protein tyrosine kinase activity|upregulation of focal adhesion kinase activity|upregulation of janus kinase 1 activity|upregulation of janus kinase 2 activity|upregulation of janus kinase 3 activity|upregulation of non-membrane spanning protein tyrosine kinase activity|upregulation of non-specific protein-tyrosine kinase activity|upregulation of p60c-src protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_1903997 gocheck_do_not_annotate GO:1903996 biolink:BiologicalProcess negative regulation of non-membrane spanning protein tyrosine kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. go.json down regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|down regulation of Bruton's tyrosine kinase activity|down regulation of cytoplasmic protein tyrosine kinase activity|down regulation of focal adhesion kinase activity|down regulation of janus kinase 1 activity|down regulation of janus kinase 2 activity|down regulation of janus kinase 3 activity|down regulation of non-membrane spanning protein tyrosine kinase activity|down regulation of non-specific protein-tyrosine kinase activity|down regulation of p60c-src protein tyrosine kinase activity|down-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|down-regulation of Bruton's tyrosine kinase activity|down-regulation of cytoplasmic protein tyrosine kinase activity|down-regulation of focal adhesion kinase activity|down-regulation of janus kinase 1 activity|down-regulation of janus kinase 2 activity|down-regulation of janus kinase 3 activity|down-regulation of non-membrane spanning protein tyrosine kinase activity|down-regulation of non-specific protein-tyrosine kinase activity|down-regulation of p60c-src protein tyrosine kinase activity|downregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|downregulation of Bruton's tyrosine kinase activity|downregulation of cytoplasmic protein tyrosine kinase activity|downregulation of focal adhesion kinase activity|downregulation of janus kinase 1 activity|downregulation of janus kinase 2 activity|downregulation of janus kinase 3 activity|downregulation of non-membrane spanning protein tyrosine kinase activity|downregulation of non-specific protein-tyrosine kinase activity|downregulation of p60c-src protein tyrosine kinase activity|inhibition of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|inhibition of Bruton's tyrosine kinase activity|inhibition of cytoplasmic protein tyrosine kinase activity|inhibition of focal adhesion kinase activity|inhibition of janus kinase 1 activity|inhibition of janus kinase 2 activity|inhibition of janus kinase 3 activity|inhibition of non-membrane spanning protein tyrosine kinase activity|inhibition of non-specific protein-tyrosine kinase activity|inhibition of p60c-src protein tyrosine kinase activity|negative regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|negative regulation of Bruton's tyrosine kinase activity|negative regulation of cytoplasmic protein tyrosine kinase activity|negative regulation of focal adhesion kinase activity|negative regulation of janus kinase 1 activity|negative regulation of janus kinase 2 activity|negative regulation of janus kinase 3 activity|negative regulation of non-specific protein-tyrosine kinase activity|negative regulation of p60c-src protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_1903996 gocheck_do_not_annotate GO:1903995 biolink:BiologicalProcess regulation of non-membrane spanning protein tyrosine kinase activity Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. go.json regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|regulation of ATP:protein-tyrosine O-phosphotransferase activity|regulation of Bruton's tyrosine kinase activity|regulation of cytoplasmic protein tyrosine kinase activity|regulation of focal adhesion kinase activity|regulation of janus kinase 1 activity|regulation of janus kinase 2 activity|regulation of janus kinase 3 activity|regulation of non-specific protein-tyrosine kinase activity|regulation of p60c-src protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_1903995 gocheck_do_not_annotate GO:1903994 biolink:BiologicalProcess obsolete positive regulation of protein stabilization OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein stabilization. go.json activation of lysosomal protein stabilization|activation of positive regulation of protein stability|activation of protein sequestering|activation of protein stabilization|activation of protein stabilization activity|positive regulation of lysosomal protein stabilization|positive regulation of positive regulation of protein stability|positive regulation of protein sequestering|positive regulation of protein stabilization|positive regulation of protein stabilization activity|up regulation of lysosomal protein stabilization|up regulation of positive regulation of protein stability|up regulation of protein sequestering|up regulation of protein stabilization|up regulation of protein stabilization activity|up-regulation of lysosomal protein stabilization|up-regulation of positive regulation of protein stability|up-regulation of protein sequestering|up-regulation of protein stabilization|up-regulation of protein stabilization activity|upregulation of lysosomal protein stabilization|upregulation of positive regulation of protein stability|upregulation of protein sequestering|upregulation of protein stabilization|upregulation of protein stabilization activity True http://purl.obolibrary.org/obo/GO_1903994 GO:0048599 biolink:BiologicalProcess oocyte development The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0048599 GO:1903993 biolink:BiologicalProcess obsolete negative regulation of protein stabilization OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein stabilization. go.json down regulation of lysosomal protein stabilization|down regulation of positive regulation of protein stability|down regulation of protein sequestering|down regulation of protein stabilization|down regulation of protein stabilization activity|down-regulation of lysosomal protein stabilization|down-regulation of positive regulation of protein stability|down-regulation of protein sequestering|down-regulation of protein stabilization|down-regulation of protein stabilization activity|downregulation of lysosomal protein stabilization|downregulation of positive regulation of protein stability|downregulation of protein sequestering|downregulation of protein stabilization|downregulation of protein stabilization activity|inhibition of lysosomal protein stabilization|inhibition of positive regulation of protein stability|inhibition of protein sequestering|inhibition of protein stabilization|inhibition of protein stabilization activity|negative regulation of lysosomal protein stabilization|negative regulation of positive regulation of protein stability|negative regulation of protein sequestering|negative regulation of protein stabilization|negative regulation of protein stabilization activity True http://purl.obolibrary.org/obo/GO_1903993 GO:0048598 biolink:BiologicalProcess embryonic morphogenesis The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. go.json embryonic anatomical structure morphogenesis http://purl.obolibrary.org/obo/GO_0048598 GO:1903992 biolink:BiologicalProcess obsolete regulation of protein stabilization OBSOLETE. Any process that modulates the frequency, rate or extent of protein stabilization. go.json regulation of lysosomal protein stabilization|regulation of positive regulation of protein stability|regulation of protein sequestering|regulation of protein stabilization|regulation of protein stabilization activity True http://purl.obolibrary.org/obo/GO_1903992 GO:0048597 biolink:BiologicalProcess post-embryonic camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized during post-embryonic development. go.json post-embryonic camera-style eye morphogenesis|post-embryonic eye morphogenesis http://purl.obolibrary.org/obo/GO_0048597 GO:0097527 biolink:BiologicalProcess necroptotic signaling pathway The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered. go.json necroptosis signaling|necroptosis signaling pathway|necroptotic signal transduction|necroptotic signalling pathway http://purl.obolibrary.org/obo/GO_0097527 GO:0097526 biolink:CellularComponent spliceosomal tri-snRNP complex A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. go.json http://purl.obolibrary.org/obo/GO_0097526 GO:0097529 biolink:BiologicalProcess myeloid leukocyte migration The movement of a myeloid leukocyte within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0097529 GO:0097528 biolink:BiologicalProcess execution phase of necroptosis A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died. go.json execution phase of necroptotic process|necroptosis|necroptotic execution phase http://purl.obolibrary.org/obo/GO_0097528 GO:0097523 biolink:CellularComponent transcription ternary complex A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript. go.json transcription protein-DNA-RNA complex http://purl.obolibrary.org/obo/GO_0097523 GO:0097522 biolink:CellularComponent protein-DNA ISRE complex A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA. go.json http://purl.obolibrary.org/obo/GO_0097522 GO:0097525 biolink:CellularComponent spliceosomal snRNP complex A small ribonucleoprotein complex involved in formation of the spliceosome. go.json http://purl.obolibrary.org/obo/GO_0097525 GO:0097524 biolink:CellularComponent sperm plasma membrane A plasma membrane that is part of a sperm cell. go.json http://purl.obolibrary.org/obo/GO_0097524 GO:0097509 biolink:MolecularActivity oxanine DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination. go.json oxanine-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0097509 GO:0097508 biolink:MolecularActivity xanthine DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated guanine (xanthine). go.json xanthine-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0097508 GO:0097505 biolink:CellularComponent Rad6-Rad18 complex A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity. go.json http://purl.obolibrary.org/obo/GO_0097505 GO:0097504 biolink:CellularComponent Gemini of coiled bodies Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). go.json Gems http://purl.obolibrary.org/obo/GO_0097504 GO:0097507 biolink:MolecularActivity hypoxanthine DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine). go.json hypoxanthine-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0097507 GO:0097506 biolink:MolecularActivity deaminated base DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated bases. go.json DNA glycosylase activity acting on deaminated bases|deaminated base DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0097506 GO:0097501 biolink:BiologicalProcess stress response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus. go.json response to excess metal ion|response to metal ion stress|response to metal ion toxicity|response to metal toxicity http://purl.obolibrary.org/obo/GO_0097501 GO:0097500 biolink:BiologicalProcess receptor localization to non-motile cilium A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium. go.json receptor localization to nonmotile primary cilium http://purl.obolibrary.org/obo/GO_0097500 GO:0097503 biolink:BiologicalProcess sialylation The covalent attachment of sialic acid to a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0097503 GO:0097502 biolink:BiologicalProcess mannosylation The covalent attachment of a mannose residue to a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0097502 GO:0097552 biolink:BiologicalProcess mitochondrial double-strand break repair via homologous recombination The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences. go.json mtDSB repair via homologous recombination http://purl.obolibrary.org/obo/GO_0097552 GO:0097551 biolink:BiologicalProcess mitochondrial double-strand break repair The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. go.json mtDSB repair http://purl.obolibrary.org/obo/GO_0097551 GO:0097554 biolink:CellularComponent left anterior flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell. go.json left anterior cilium http://purl.obolibrary.org/obo/GO_0097554 GO:0097553 biolink:BiologicalProcess calcium ion transmembrane import into cytosol A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. go.json calcium transmembrane import into cytosol|cytosolic calcium ion transport http://purl.obolibrary.org/obo/GO_0097553 GO:0097550 biolink:CellularComponent transcription preinitiation complex A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. go.json DNA-templated transcriptional preinitiation complex|PIC|preinitiation complex|transcriptional pre-initiation complex|transcriptional preinitiation complex http://purl.obolibrary.org/obo/GO_0097550 GO:0097559 biolink:CellularComponent right ventral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc. go.json right ventral cilium http://purl.obolibrary.org/obo/GO_0097559 GO:0097556 biolink:CellularComponent left posteriolateral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body. go.json left posteriolateral cilium|left posterolateral cilium|left posterolateral flagellum http://purl.obolibrary.org/obo/GO_0097556 GO:0097555 biolink:CellularComponent right anterior flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell. go.json right anterior cilium http://purl.obolibrary.org/obo/GO_0097555 GO:0097558 biolink:CellularComponent left ventral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc. go.json left ventral cilium http://purl.obolibrary.org/obo/GO_0097558 GO:0097557 biolink:CellularComponent right posteriolateral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body. go.json right posteriolateral cilium|right posterolateral cilium|right posterolateral flagellum http://purl.obolibrary.org/obo/GO_0097557 GO:0097563 biolink:CellularComponent left middle basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally. go.json http://purl.obolibrary.org/obo/GO_0097563 GO:0097562 biolink:CellularComponent left lateral basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally. go.json http://purl.obolibrary.org/obo/GO_0097562 GO:0097565 biolink:CellularComponent right middle basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally. go.json http://purl.obolibrary.org/obo/GO_0097565 GO:0097564 biolink:CellularComponent right lateral basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally. go.json http://purl.obolibrary.org/obo/GO_0097564 GO:0097561 biolink:CellularComponent right caudal flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body. go.json right caudal cilium http://purl.obolibrary.org/obo/GO_0097561 GO:0097560 biolink:CellularComponent left caudal flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body. go.json left caudal cilium http://purl.obolibrary.org/obo/GO_0097560 GO:0097567 biolink:CellularComponent right tetrad Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally). go.json http://purl.obolibrary.org/obo/GO_0097567 GO:0097566 biolink:CellularComponent left tetrad Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally). go.json http://purl.obolibrary.org/obo/GO_0097566 GO:0097569 biolink:CellularComponent lateral shield Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella. go.json http://purl.obolibrary.org/obo/GO_0097569 GO:0097568 biolink:CellularComponent median body A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc. go.json parabasal body http://purl.obolibrary.org/obo/GO_0097568 GO:0097530 biolink:BiologicalProcess granulocyte migration The movement of a granulocyte within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0097530 GO:0097532 biolink:BiologicalProcess stress response to acid chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. go.json response to acid stress|stress response to acid http://purl.obolibrary.org/obo/GO_0097532 GO:0097531 biolink:BiologicalProcess mast cell migration The movement of a mast cell within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0097531 GO:0097538 biolink:CellularComponent ciliary necklace A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links. go.json cilial necklace|cilium necklace http://purl.obolibrary.org/obo/GO_0097538 GO:0097537 biolink:CellularComponent Y-shaped link A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium. go.json Y-link|Y-link structure|Y-shaped assemblage|Y-shaped fiber|Y-shaped fibre|Y-shaped linker|membrane-microtubule complex http://purl.obolibrary.org/obo/GO_0097537 GO:0097539 biolink:CellularComponent ciliary transition fiber A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). go.json centriolar distal appendage|cilial transition fiber|cilial transition fibre|ciliary transition fibre|cilium transition fiber|cilium transition fibre|distal appendage of basal body|distal appendage of centriole|distal appendage of mother centriole|transition fiber|transition fibre http://purl.obolibrary.org/obo/GO_0097539 GO:0097534 biolink:BiologicalProcess lymphoid lineage cell migration The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. go.json lymphoid lineage restricted progenitor cell migration http://purl.obolibrary.org/obo/GO_0097534 GO:0097533 biolink:BiologicalProcess cellular stress response to acid chemical Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. go.json cellular response to acid stress|cellular stress response to acid http://purl.obolibrary.org/obo/GO_0097533 GO:0097536 biolink:BiologicalProcess thymus epithelium morphogenesis The process in which the thymus epithelium is generated and organized. go.json thymic epithelium morphogenesis http://purl.obolibrary.org/obo/GO_0097536 GO:0097535 biolink:BiologicalProcess lymphoid lineage cell migration into thymus The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process. go.json lymphoid lineage restricted progenitor cell migration into thymus http://purl.obolibrary.org/obo/GO_0097535 GO:0097541 biolink:CellularComponent axonemal basal plate Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure. go.json axoneme basal plate|basal plate http://purl.obolibrary.org/obo/GO_0097541 GO:0097540 biolink:CellularComponent axonemal central pair Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia. go.json axonemal microtubule central pair|axoneme central pair|axoneme microtubule central pair|central pair|central-pair microtubules http://purl.obolibrary.org/obo/GO_0097540 GO:0097543 biolink:CellularComponent ciliary inversin compartment Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium. go.json Inv compartment of the cilium|cilial inversin compartment|cilium inversin compartment|flagellar inversin compartment|flagellum inversin compartment|inversin compartment http://purl.obolibrary.org/obo/GO_0097543 GO:0097542 biolink:CellularComponent ciliary tip Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. go.json cilial tip|cilium tip|flagellar tip|flagellum tip http://purl.obolibrary.org/obo/GO_0097542 GO:0097549 biolink:BiologicalProcess obsolete chromatin organization involved in negative regulation of transcription OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization. go.json negative regulation of gene-specific transcription from RNA polymerase II promoter by histone modification|negative regulation of global transcription from Pol II promoter by histone modification|negative regulation of transcription by chromatin organization|negative regulation of transcription from Pol II promoter by histone modification|negative regulation of transcription from RNA polymerase II promoter by histone modification|negative regulation of transcription from RNA polymerase II promoter, global by histone modification True http://purl.obolibrary.org/obo/GO_0097549 GO:0097548 biolink:BiologicalProcess seed abscission The controlled shedding of a seed. go.json http://purl.obolibrary.org/obo/GO_0097548 GO:0097545 biolink:CellularComponent axonemal outer doublet Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium. go.json axoneme outer doublet|outer doublet|outer-doublet microtubules http://purl.obolibrary.org/obo/GO_0097545 GO:0097544 biolink:CellularComponent ciliary shaft The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space. go.json cilial shaft|cilium shaft|flagellar shaft|flagellum shaft http://purl.obolibrary.org/obo/GO_0097544 GO:0097547 biolink:CellularComponent synaptic vesicle protein transport vesicle A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon. go.json STV http://purl.obolibrary.org/obo/GO_0097547 GO:0097546 biolink:CellularComponent ciliary base Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. go.json cilial base|cilium base|flagellar base|flagellum base http://purl.obolibrary.org/obo/GO_0097546 GO:1903908 biolink:BiologicalProcess positive regulation of plasma membrane raft polarization Any process that activates or increases the frequency, rate or extent of plasma membrane raft polarization. go.json activation of plasma membrane raft polarization|up regulation of plasma membrane raft polarization|up-regulation of plasma membrane raft polarization|upregulation of plasma membrane raft polarization http://purl.obolibrary.org/obo/GO_1903908 GO:1903907 biolink:BiologicalProcess negative regulation of plasma membrane raft polarization Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane raft polarization. go.json down regulation of plasma membrane raft polarization|down-regulation of plasma membrane raft polarization|downregulation of plasma membrane raft polarization|inhibition of plasma membrane raft polarization http://purl.obolibrary.org/obo/GO_1903907 GO:1903906 biolink:BiologicalProcess regulation of plasma membrane raft polarization Any process that modulates the frequency, rate or extent of plasma membrane raft polarization. go.json http://purl.obolibrary.org/obo/GO_1903906 GO:1903905 biolink:BiologicalProcess positive regulation of establishment of T cell polarity Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. go.json activation of T cell polarization|activation of T lymphocyte polarization|activation of T-cell polarization|activation of establishment of T cell polarity|activation of establishment of T lymphocyte polarity|activation of establishment of T-cell polarity|activation of establishment of T-lymphocyte polarity|positive regulation of T cell polarization|positive regulation of T lymphocyte polarization|positive regulation of T-cell polarization|positive regulation of establishment of T lymphocyte polarity|positive regulation of establishment of T-cell polarity|positive regulation of establishment of T-lymphocyte polarity|up regulation of T cell polarization|up regulation of T lymphocyte polarization|up regulation of T-cell polarization|up regulation of establishment of T cell polarity|up regulation of establishment of T lymphocyte polarity|up regulation of establishment of T-cell polarity|up regulation of establishment of T-lymphocyte polarity|up-regulation of T cell polarization|up-regulation of T lymphocyte polarization|up-regulation of T-cell polarization|up-regulation of establishment of T cell polarity|up-regulation of establishment of T lymphocyte polarity|up-regulation of establishment of T-cell polarity|up-regulation of establishment of T-lymphocyte polarity|upregulation of T cell polarization|upregulation of T lymphocyte polarization|upregulation of T-cell polarization|upregulation of establishment of T cell polarity|upregulation of establishment of T lymphocyte polarity|upregulation of establishment of T-cell polarity|upregulation of establishment of T-lymphocyte polarity http://purl.obolibrary.org/obo/GO_1903905 GO:1903904 biolink:BiologicalProcess negative regulation of establishment of T cell polarity Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. go.json down regulation of T cell polarization|down regulation of T lymphocyte polarization|down regulation of T-cell polarization|down regulation of establishment of T cell polarity|down regulation of establishment of T lymphocyte polarity|down regulation of establishment of T-cell polarity|down regulation of establishment of T-lymphocyte polarity|down-regulation of T cell polarization|down-regulation of T lymphocyte polarization|down-regulation of T-cell polarization|down-regulation of establishment of T cell polarity|down-regulation of establishment of T lymphocyte polarity|down-regulation of establishment of T-cell polarity|down-regulation of establishment of T-lymphocyte polarity|downregulation of T cell polarization|downregulation of T lymphocyte polarization|downregulation of T-cell polarization|downregulation of establishment of T cell polarity|downregulation of establishment of T lymphocyte polarity|downregulation of establishment of T-cell polarity|downregulation of establishment of T-lymphocyte polarity|inhibition of T cell polarization|inhibition of T lymphocyte polarization|inhibition of T-cell polarization|inhibition of establishment of T cell polarity|inhibition of establishment of T lymphocyte polarity|inhibition of establishment of T-cell polarity|inhibition of establishment of T-lymphocyte polarity|negative regulation of T cell polarization|negative regulation of T lymphocyte polarization|negative regulation of T-cell polarization|negative regulation of establishment of T lymphocyte polarity|negative regulation of establishment of T-cell polarity|negative regulation of establishment of T-lymphocyte polarity http://purl.obolibrary.org/obo/GO_1903904 GO:1903903 biolink:BiologicalProcess regulation of establishment of T cell polarity Any process that modulates the frequency, rate or extent of establishment of T cell polarity. go.json regulation of T cell polarization|regulation of T lymphocyte polarization|regulation of T-cell polarization|regulation of establishment of T lymphocyte polarity|regulation of establishment of T-cell polarity|regulation of establishment of T-lymphocyte polarity http://purl.obolibrary.org/obo/GO_1903903 GO:1903902 biolink:BiologicalProcess positive regulation of viral life cycle Any process that activates or increases the frequency, rate or extent of viral life cycle. go.json activation of lytic viral life cycle|activation of viral assembly, maturation, egress, and release|activation of viral infectious cycle|activation of viral life cycle|activation of viral replication|positive regulation of lytic viral life cycle|positive regulation of viral assembly, maturation, egress, and release|positive regulation of viral infectious cycle|positive regulation of viral replication|up regulation of lytic viral life cycle|up regulation of viral assembly, maturation, egress, and release|up regulation of viral infectious cycle|up regulation of viral life cycle|up regulation of viral replication|up-regulation of lytic viral life cycle|up-regulation of viral assembly, maturation, egress, and release|up-regulation of viral infectious cycle|up-regulation of viral life cycle|up-regulation of viral replication|upregulation of lytic viral life cycle|upregulation of viral assembly, maturation, egress, and release|upregulation of viral infectious cycle|upregulation of viral life cycle|upregulation of viral replication http://purl.obolibrary.org/obo/GO_1903902 GO:1903901 biolink:BiologicalProcess negative regulation of viral life cycle Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle. go.json down regulation of lytic viral life cycle|down regulation of viral assembly, maturation, egress, and release|down regulation of viral infectious cycle|down regulation of viral life cycle|down regulation of viral replication|down-regulation of lytic viral life cycle|down-regulation of viral assembly, maturation, egress, and release|down-regulation of viral infectious cycle|down-regulation of viral life cycle|down-regulation of viral replication|downregulation of lytic viral life cycle|downregulation of viral assembly, maturation, egress, and release|downregulation of viral infectious cycle|downregulation of viral life cycle|downregulation of viral replication|inhibition of lytic viral life cycle|inhibition of viral assembly, maturation, egress, and release|inhibition of viral infectious cycle|inhibition of viral life cycle|inhibition of viral replication|negative regulation of lytic viral life cycle|negative regulation of viral assembly, maturation, egress, and release|negative regulation of viral infectious cycle|negative regulation of viral replication http://purl.obolibrary.org/obo/GO_1903901 GO:1903900 biolink:BiologicalProcess regulation of viral life cycle Any process that modulates the frequency, rate or extent of viral life cycle. go.json regulation of lytic viral life cycle|regulation of viral assembly, maturation, egress, and release|regulation of viral infectious cycle|regulation of viral replication http://purl.obolibrary.org/obo/GO_1903900 GO:0048505 biolink:BiologicalProcess regulation of timing of cell differentiation The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. go.json timing of cell differentiation http://purl.obolibrary.org/obo/GO_0048505 GO:0048504 biolink:BiologicalProcess regulation of timing of animal organ formation Any process that modulates the rate, frequency or extent of animal organ formation at a consistent predetermined time point during development. go.json timing of organ biosynthesis|timing of organ formation http://purl.obolibrary.org/obo/GO_0048504 GO:0048503 biolink:MolecularActivity obsolete GPI anchor binding OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. go.json GPI anchor binding|glycosylphosphatidylinositol binding True http://purl.obolibrary.org/obo/GO_0048503 GO:0048502 biolink:MolecularActivity ABC-type thiamine transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H+ + phosphate + thiamine(in). EC:7.6.2.15|RHEA:29811|TC:3.A.1.19.1 go.json ATP-dependent thiamine transmembrane transporter activity|ATPase-coupled thiamine transmembrane transporter activity|TPP transporting ATPase activity|thiamin pyrophosphate ABC transporter|thiamin pyrophosphate porter activity|thiamin pyrophosphate transporting ATPase activity|thiamin-transporting ATPase activity|thiamine ABC transporter|thiamine pyrophosphate-transporting ATPase activity|thiamine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0048502 GO:0048501 biolink:CellularComponent signal recognition particle, plasma membrane targeting A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0048501 GO:0048500 biolink:CellularComponent signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. Wikipedia:Signal_recognition_particle go.json http://purl.obolibrary.org/obo/GO_0048500 goslim_metagenomics|goslim_pir GO:0048509 biolink:BiologicalProcess regulation of meristem development Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048509 GO:0048508 biolink:BiologicalProcess embryonic meristem development The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048508 GO:0048507 biolink:BiologicalProcess meristem development The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048507 GO:0048506 biolink:BiologicalProcess regulation of timing of meristematic phase transition Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point. go.json http://purl.obolibrary.org/obo/GO_0048506 GO:1903909 biolink:BiologicalProcess regulation of receptor clustering Any process that modulates the frequency, rate or extent of receptor clustering. go.json http://purl.obolibrary.org/obo/GO_1903909 GO:1903919 biolink:BiologicalProcess negative regulation of actin filament severing Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing. go.json down regulation of F-actin severing|down regulation of actin filament severing|down regulation of actin filament severing activity|down regulation of barbed-end actin capping/severing activity|down-regulation of F-actin severing|down-regulation of actin filament severing|down-regulation of actin filament severing activity|down-regulation of barbed-end actin capping/severing activity|downregulation of F-actin severing|downregulation of actin filament severing|downregulation of actin filament severing activity|downregulation of barbed-end actin capping/severing activity|inhibition of F-actin severing|inhibition of actin filament severing|inhibition of actin filament severing activity|inhibition of barbed-end actin capping/severing activity|negative regulation of F-actin severing|negative regulation of actin filament severing activity|negative regulation of barbed-end actin capping/severing activity http://purl.obolibrary.org/obo/GO_1903919 GO:1903918 biolink:BiologicalProcess regulation of actin filament severing Any process that modulates the frequency, rate or extent of actin filament severing. go.json regulation of F-actin severing|regulation of actin filament severing activity|regulation of barbed-end actin capping/severing activity http://purl.obolibrary.org/obo/GO_1903918 GO:1903917 biolink:BiologicalProcess positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation. go.json activation of eIF2alpha dephosphorylation in response to ER stress|activation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|activation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|positive regulation of ER stress-induced eIF2 alpha dephosphorylation|positive regulation of eIF2alpha dephosphorylation in response to ER stress|positive regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|positive regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|up regulation of eIF2alpha dephosphorylation in response to ER stress|up regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|up regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|up-regulation of eIF2alpha dephosphorylation in response to ER stress|up-regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|up-regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|upregulation of eIF2alpha dephosphorylation in response to ER stress|upregulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|upregulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1903917 GO:1903916 biolink:BiologicalProcess regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation. go.json regulation of ER stress-induced eIF2 alpha dephosphorylation|regulation of eIF2alpha dephosphorylation in response to ER stress|regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress|regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1903916 GO:1903915 biolink:BiologicalProcess positive regulation of fusion of virus membrane with host plasma membrane Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane. go.json activation of fusion of virus membrane with host plasma membrane|activation of viral entry into host cell via membrane fusion with the plasma membrane|activation of viral envelope fusion with host cell membrane|activation of viral envelope fusion with host membrane|activation of viral envelope fusion with host plasma membrane|activation of viral penetration via membrane fusion|activation of viral-cell fusion molecule activity|positive regulation of viral entry into host cell via membrane fusion with the plasma membrane|positive regulation of viral envelope fusion with host cell membrane|positive regulation of viral envelope fusion with host membrane|positive regulation of viral envelope fusion with host plasma membrane|positive regulation of viral penetration via membrane fusion|positive regulation of viral-cell fusion molecule activity|up regulation of fusion of virus membrane with host plasma membrane|up regulation of viral entry into host cell via membrane fusion with the plasma membrane|up regulation of viral envelope fusion with host cell membrane|up regulation of viral envelope fusion with host membrane|up regulation of viral envelope fusion with host plasma membrane|up regulation of viral penetration via membrane fusion|up regulation of viral-cell fusion molecule activity|up-regulation of fusion of virus membrane with host plasma membrane|up-regulation of viral entry into host cell via membrane fusion with the plasma membrane|up-regulation of viral envelope fusion with host cell membrane|up-regulation of viral envelope fusion with host membrane|up-regulation of viral envelope fusion with host plasma membrane|up-regulation of viral penetration via membrane fusion|up-regulation of viral-cell fusion molecule activity|upregulation of fusion of virus membrane with host plasma membrane|upregulation of viral entry into host cell via membrane fusion with the plasma membrane|upregulation of viral envelope fusion with host cell membrane|upregulation of viral envelope fusion with host membrane|upregulation of viral envelope fusion with host plasma membrane|upregulation of viral penetration via membrane fusion|upregulation of viral-cell fusion molecule activity http://purl.obolibrary.org/obo/GO_1903915 GO:1903914 biolink:BiologicalProcess negative regulation of fusion of virus membrane with host plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane. go.json down regulation of fusion of virus membrane with host plasma membrane|down regulation of viral entry into host cell via membrane fusion with the plasma membrane|down regulation of viral envelope fusion with host cell membrane|down regulation of viral envelope fusion with host membrane|down regulation of viral envelope fusion with host plasma membrane|down regulation of viral penetration via membrane fusion|down regulation of viral-cell fusion molecule activity|down-regulation of fusion of virus membrane with host plasma membrane|down-regulation of viral entry into host cell via membrane fusion with the plasma membrane|down-regulation of viral envelope fusion with host cell membrane|down-regulation of viral envelope fusion with host membrane|down-regulation of viral envelope fusion with host plasma membrane|down-regulation of viral penetration via membrane fusion|down-regulation of viral-cell fusion molecule activity|downregulation of fusion of virus membrane with host plasma membrane|downregulation of viral entry into host cell via membrane fusion with the plasma membrane|downregulation of viral envelope fusion with host cell membrane|downregulation of viral envelope fusion with host membrane|downregulation of viral envelope fusion with host plasma membrane|downregulation of viral penetration via membrane fusion|downregulation of viral-cell fusion molecule activity|inhibition of fusion of virus membrane with host plasma membrane|inhibition of viral entry into host cell via membrane fusion with the plasma membrane|inhibition of viral envelope fusion with host cell membrane|inhibition of viral envelope fusion with host membrane|inhibition of viral envelope fusion with host plasma membrane|inhibition of viral penetration via membrane fusion|inhibition of viral-cell fusion molecule activity|negative regulation of viral entry into host cell via membrane fusion with the plasma membrane|negative regulation of viral envelope fusion with host cell membrane|negative regulation of viral envelope fusion with host membrane|negative regulation of viral envelope fusion with host plasma membrane|negative regulation of viral penetration via membrane fusion|negative regulation of viral-cell fusion molecule activity http://purl.obolibrary.org/obo/GO_1903914 GO:1903913 biolink:BiologicalProcess regulation of fusion of virus membrane with host plasma membrane Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane. go.json regulation of viral entry into host cell via membrane fusion with the plasma membrane|regulation of viral envelope fusion|regulation of viral envelope fusion with host cell membrane|regulation of viral envelope fusion with host membrane|regulation of viral envelope fusion with host plasma membrane|regulation of viral penetration via membrane fusion|regulation of viral-cell fusion molecule activity http://purl.obolibrary.org/obo/GO_1903913 GO:1903912 biolink:BiologicalProcess negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation. go.json down regulation of eiF2alpha phosphorylation in response to ER stress|down regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress|down regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress|down-regulation of eiF2alpha phosphorylation in response to ER stress|down-regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress|down-regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress|downregulation of eiF2alpha phosphorylation in response to ER stress|downregulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress|downregulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress|inhibition of eiF2alpha phosphorylation in response to ER stress|inhibition of eiF2alpha phosphorylation in response to endoplasmic reticulum stress|inhibition of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress|negative regulation of ER stress-induced eIF2 alpha phosphorylation|negative regulation of eiF2alpha phosphorylation in response to ER stress|negative regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress|negative regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress http://purl.obolibrary.org/obo/GO_1903912 GO:1903911 biolink:BiologicalProcess positive regulation of receptor clustering Any process that activates or increases the frequency, rate or extent of receptor clustering. go.json activation of receptor clustering|up regulation of receptor clustering|up-regulation of receptor clustering|upregulation of receptor clustering http://purl.obolibrary.org/obo/GO_1903911 GO:0048516 biolink:BiologicalProcess obsolete trichome initiation (sensu Magnoliophyta) OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). go.json trichome initiation (sensu Magnoliophyta) True http://purl.obolibrary.org/obo/GO_0048516 GO:1903910 biolink:BiologicalProcess negative regulation of receptor clustering Any process that stops, prevents or reduces the frequency, rate or extent of receptor clustering. go.json down regulation of receptor clustering|down-regulation of receptor clustering|downregulation of receptor clustering|inhibition of receptor clustering http://purl.obolibrary.org/obo/GO_1903910 GO:0048515 biolink:BiologicalProcess spermatid differentiation The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json spermatid cell differentiation http://purl.obolibrary.org/obo/GO_0048515 GO:0048514 biolink:BiologicalProcess blood vessel morphogenesis The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. go.json http://purl.obolibrary.org/obo/GO_0048514 GO:0048513 biolink:BiologicalProcess animal organ development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. Wikipedia:Organogenesis go.json development of an organ|organogenesis http://purl.obolibrary.org/obo/GO_0048513 GO:0048512 biolink:BiologicalProcess circadian behavior The specific behavior of an organism that recurs with a regularity of approximately 24 hours. go.json circadian rhythm behavior http://purl.obolibrary.org/obo/GO_0048512 GO:0048511 biolink:BiologicalProcess rhythmic process Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. go.json rhythm http://purl.obolibrary.org/obo/GO_0048511 goslim_pir GO:0048510 biolink:BiologicalProcess regulation of timing of transition from vegetative to reproductive phase The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs. go.json http://purl.obolibrary.org/obo/GO_0048510 GO:0048519 biolink:BiologicalProcess negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. go.json down regulation of biological process|down-regulation of biological process|downregulation of biological process|inhibition of biological process|negative regulation of physiological process http://purl.obolibrary.org/obo/GO_0048519 gocheck_do_not_annotate GO:0048518 biolink:BiologicalProcess positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. go.json activation of biological process|positive regulation of physiological process|stimulation of biological process|up regulation of biological process|up-regulation of biological process|upregulation of biological process http://purl.obolibrary.org/obo/GO_0048518 gocheck_do_not_annotate GO:0048517 biolink:BiologicalProcess obsolete positive regulation of trichome initiation (sensu Magnoliophyta) OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). go.json positive regulation of trichome initiation (sensu Magnoliophyta) True http://purl.obolibrary.org/obo/GO_0048517 GO:1903929 biolink:BiologicalProcess primary palate development The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure. go.json palatum primarium development|primary palate process development|primitive palate development|processus palatinus medianus development http://purl.obolibrary.org/obo/GO_1903929 GO:1903928 biolink:BiologicalProcess cellular response to cyanide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus. go.json http://purl.obolibrary.org/obo/GO_1903928 GO:1903927 biolink:BiologicalProcess response to cyanide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus. go.json http://purl.obolibrary.org/obo/GO_1903927 GO:1903926 biolink:BiologicalProcess cellular response to bisphenol A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus. go.json http://purl.obolibrary.org/obo/GO_1903926 GO:1903925 biolink:BiologicalProcess response to bisphenol A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus. go.json http://purl.obolibrary.org/obo/GO_1903925 GO:1903924 biolink:MolecularActivity estradiol binding Binding to estradiol. go.json http://purl.obolibrary.org/obo/GO_1903924 GO:1903923 biolink:BiologicalProcess positive regulation of protein processing in phagocytic vesicle Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle. go.json activation of peptidolysis during protein maturation in phagocytic vesicle|activation of peptidolysis during protein maturation in phagosome|activation of protein maturation by peptide bond cleavage in phagocytic vesicle|activation of protein maturation by peptide bond cleavage in phagosome|activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|activation of protein maturation by peptide bond hydrolysis in phagosome|activation of protein maturation by proteolysis in phagocytic vesicle|activation of protein maturation by proteolysis in phagosome|activation of protein processing in phagocytic vesicle|activation of protein processing in phagosome|positive regulation of peptidolysis during protein maturation in phagocytic vesicle|positive regulation of peptidolysis during protein maturation in phagosome|positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|positive regulation of protein maturation by peptide bond cleavage in phagosome|positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|positive regulation of protein maturation by peptide bond hydrolysis in phagosome|positive regulation of protein maturation by proteolysis in phagocytic vesicle|positive regulation of protein maturation by proteolysis in phagosome|positive regulation of protein processing in phagosome|up regulation of peptidolysis during protein maturation in phagocytic vesicle|up regulation of peptidolysis during protein maturation in phagosome|up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|up regulation of protein maturation by peptide bond cleavage in phagosome|up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|up regulation of protein maturation by peptide bond hydrolysis in phagosome|up regulation of protein maturation by proteolysis in phagocytic vesicle|up regulation of protein maturation by proteolysis in phagosome|up regulation of protein processing in phagocytic vesicle|up regulation of protein processing in phagosome|up-regulation of peptidolysis during protein maturation in phagocytic vesicle|up-regulation of peptidolysis during protein maturation in phagosome|up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|up-regulation of protein maturation by peptide bond cleavage in phagosome|up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|up-regulation of protein maturation by peptide bond hydrolysis in phagosome|up-regulation of protein maturation by proteolysis in phagocytic vesicle|up-regulation of protein maturation by proteolysis in phagosome|up-regulation of protein processing in phagocytic vesicle|up-regulation of protein processing in phagosome|upregulation of peptidolysis during protein maturation in phagocytic vesicle|upregulation of peptidolysis during protein maturation in phagosome|upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle|upregulation of protein maturation by peptide bond cleavage in phagosome|upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|upregulation of protein maturation by peptide bond hydrolysis in phagosome|upregulation of protein maturation by proteolysis in phagocytic vesicle|upregulation of protein maturation by proteolysis in phagosome|upregulation of protein processing in phagocytic vesicle|upregulation of protein processing in phagosome http://purl.obolibrary.org/obo/GO_1903923 GO:1903922 biolink:BiologicalProcess negative regulation of protein processing in phagocytic vesicle Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle. go.json down regulation of peptidolysis during protein maturation in phagocytic vesicle|down regulation of peptidolysis during protein maturation in phagosome|down regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|down regulation of protein maturation by peptide bond cleavage in phagosome|down regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|down regulation of protein maturation by peptide bond hydrolysis in phagosome|down regulation of protein maturation by proteolysis in phagocytic vesicle|down regulation of protein maturation by proteolysis in phagosome|down regulation of protein processing in phagocytic vesicle|down regulation of protein processing in phagosome|down-regulation of peptidolysis during protein maturation in phagocytic vesicle|down-regulation of peptidolysis during protein maturation in phagosome|down-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|down-regulation of protein maturation by peptide bond cleavage in phagosome|down-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|down-regulation of protein maturation by peptide bond hydrolysis in phagosome|down-regulation of protein maturation by proteolysis in phagocytic vesicle|down-regulation of protein maturation by proteolysis in phagosome|down-regulation of protein processing in phagocytic vesicle|down-regulation of protein processing in phagosome|downregulation of peptidolysis during protein maturation in phagocytic vesicle|downregulation of peptidolysis during protein maturation in phagosome|downregulation of protein maturation by peptide bond cleavage in phagocytic vesicle|downregulation of protein maturation by peptide bond cleavage in phagosome|downregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|downregulation of protein maturation by peptide bond hydrolysis in phagosome|downregulation of protein maturation by proteolysis in phagocytic vesicle|downregulation of protein maturation by proteolysis in phagosome|downregulation of protein processing in phagocytic vesicle|downregulation of protein processing in phagosome|inhibition of peptidolysis during protein maturation in phagocytic vesicle|inhibition of peptidolysis during protein maturation in phagosome|inhibition of protein maturation by peptide bond cleavage in phagocytic vesicle|inhibition of protein maturation by peptide bond cleavage in phagosome|inhibition of protein maturation by peptide bond hydrolysis in phagocytic vesicle|inhibition of protein maturation by peptide bond hydrolysis in phagosome|inhibition of protein maturation by proteolysis in phagocytic vesicle|inhibition of protein maturation by proteolysis in phagosome|inhibition of protein processing in phagocytic vesicle|inhibition of protein processing in phagosome|negative regulation of peptidolysis during protein maturation in phagocytic vesicle|negative regulation of peptidolysis during protein maturation in phagosome|negative regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|negative regulation of protein maturation by peptide bond cleavage in phagosome|negative regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|negative regulation of protein maturation by peptide bond hydrolysis in phagosome|negative regulation of protein maturation by proteolysis in phagocytic vesicle|negative regulation of protein maturation by proteolysis in phagosome|negative regulation of protein processing in phagosome http://purl.obolibrary.org/obo/GO_1903922 GO:0048527 biolink:BiologicalProcess lateral root development The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. go.json http://purl.obolibrary.org/obo/GO_0048527 GO:1903921 biolink:BiologicalProcess regulation of protein processing in phagocytic vesicle Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle. go.json regulation of peptidolysis during protein maturation in phagocytic vesicle|regulation of peptidolysis during protein maturation in phagosome|regulation of protein maturation by peptide bond cleavage in phagocytic vesicle|regulation of protein maturation by peptide bond cleavage in phagosome|regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle|regulation of protein maturation by peptide bond hydrolysis in phagosome|regulation of protein maturation by proteolysis in phagocytic vesicle|regulation of protein maturation by proteolysis in phagosome|regulation of protein processing in phagosome http://purl.obolibrary.org/obo/GO_1903921 GO:0048526 biolink:BiologicalProcess imaginal disc-derived wing expansion The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing. go.json wing expansion|wing inflation http://purl.obolibrary.org/obo/GO_0048526 GO:1903920 biolink:BiologicalProcess positive regulation of actin filament severing Any process that activates or increases the frequency, rate or extent of actin filament severing. go.json activation of F-actin severing|activation of actin filament severing|activation of actin filament severing activity|activation of barbed-end actin capping/severing activity|positive regulation of F-actin severing|positive regulation of actin filament severing activity|positive regulation of barbed-end actin capping/severing activity|up regulation of F-actin severing|up regulation of actin filament severing|up regulation of actin filament severing activity|up regulation of barbed-end actin capping/severing activity|up-regulation of F-actin severing|up-regulation of actin filament severing|up-regulation of actin filament severing activity|up-regulation of barbed-end actin capping/severing activity|upregulation of F-actin severing|upregulation of actin filament severing|upregulation of actin filament severing activity|upregulation of barbed-end actin capping/severing activity http://purl.obolibrary.org/obo/GO_1903920 GO:0048525 biolink:BiologicalProcess negative regulation of viral process Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. go.json down regulation of viral life cycle|down-regulation of viral life cycle|downregulation of viral life cycle|inhibition of viral life cycle|negative regulation of viral life cycle|negative regulation of viral reproduction http://purl.obolibrary.org/obo/GO_0048525 GO:0048524 biolink:BiologicalProcess positive regulation of viral process Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. go.json activation of viral life cycle|positive regulation of viral life cycle|positive regulation of viral reproduction|stimulation of viral life cycle|up regulation of viral life cycle|up-regulation of viral life cycle|upregulation of viral life cycle http://purl.obolibrary.org/obo/GO_0048524 GO:0048523 biolink:BiologicalProcess negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. go.json down regulation of cellular process|down-regulation of cellular process|downregulation of cellular process|inhibition of cellular process|negative regulation of cellular physiological process http://purl.obolibrary.org/obo/GO_0048523 gocheck_do_not_annotate GO:0048522 biolink:BiologicalProcess positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. go.json activation of cellular process|positive regulation of cellular physiological process|stimulation of cellular process|up regulation of cellular process|up-regulation of cellular process|upregulation of cellular process http://purl.obolibrary.org/obo/GO_0048522 gocheck_do_not_annotate GO:0048521 biolink:BiologicalProcess negative regulation of behavior Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. go.json down regulation of behavior|down-regulation of behavior|downregulation of behavior|inhibition of behavior http://purl.obolibrary.org/obo/GO_0048521 GO:0048520 biolink:BiologicalProcess positive regulation of behavior Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. go.json activation of behavior|stimulation of behavior|up regulation of behavior|up-regulation of behavior|upregulation of behavior http://purl.obolibrary.org/obo/GO_0048520 GO:0048529 biolink:MolecularActivity magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. EC:1.14.13.81|RHEA:33235 go.json Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity|Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity|magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0048529 GO:0048528 biolink:BiologicalProcess post-embryonic root development The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048528 GO:0048530 biolink:BiologicalProcess fruit morphogenesis The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant. go.json http://purl.obolibrary.org/obo/GO_0048530 GO:1903939 biolink:BiologicalProcess regulation of TORC2 signaling Any process that modulates the frequency, rate or extent of TORC2 signaling. go.json regulation of TORC2 signal transduction http://purl.obolibrary.org/obo/GO_1903939 GO:1903938 biolink:BiologicalProcess cellular response to acrylamide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus. go.json http://purl.obolibrary.org/obo/GO_1903938 GO:1903937 biolink:BiologicalProcess response to acrylamide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus. go.json http://purl.obolibrary.org/obo/GO_1903937 GO:1903936 biolink:BiologicalProcess cellular response to sodium arsenite Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. go.json http://purl.obolibrary.org/obo/GO_1903936 GO:1903935 biolink:BiologicalProcess response to sodium arsenite Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. go.json http://purl.obolibrary.org/obo/GO_1903935 GO:1903934 biolink:BiologicalProcess positive regulation of DNA primase activity Any process that activates or increases the frequency, rate or extent of DNA primase activity. go.json activation of DNA primase activity|up regulation of DNA primase activity|up-regulation of DNA primase activity|upregulation of DNA primase activity http://purl.obolibrary.org/obo/GO_1903934 gocheck_do_not_annotate GO:1903933 biolink:BiologicalProcess negative regulation of DNA primase activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity. go.json down regulation of DNA primase activity|down-regulation of DNA primase activity|downregulation of DNA primase activity|inhibition of DNA primase activity http://purl.obolibrary.org/obo/GO_1903933 gocheck_do_not_annotate GO:0048538 biolink:BiologicalProcess thymus development The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. go.json http://purl.obolibrary.org/obo/GO_0048538 GO:0048537 biolink:BiologicalProcess mucosa-associated lymphoid tissue development The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. go.json BALT development|GALT development|NALT development|bronchial-associated lymphoid tissue development|gut-associated lymphoid tissue development|mucosal-associated lymphoid tissue development|nasopharyngeal-associated lymphoid tissue development http://purl.obolibrary.org/obo/GO_0048537 GO:1903932 biolink:BiologicalProcess regulation of DNA primase activity Any process that modulates the frequency, rate or extent of DNA primase activity. go.json http://purl.obolibrary.org/obo/GO_1903932 gocheck_do_not_annotate GO:1903931 biolink:BiologicalProcess positive regulation of pyrimidine-containing compound salvage Any process that activates or increases the frequency, rate or extent of pyrimidine-containing compound salvage. go.json activation of pyrimidine salvage|activation of pyrimidine-containing compound salvage|positive regulation of pyrimidine salvage|up regulation of pyrimidine salvage|up regulation of pyrimidine-containing compound salvage|up-regulation of pyrimidine salvage|up-regulation of pyrimidine-containing compound salvage|upregulation of pyrimidine salvage|upregulation of pyrimidine-containing compound salvage http://purl.obolibrary.org/obo/GO_1903931 GO:0048536 biolink:BiologicalProcess spleen development The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. go.json http://purl.obolibrary.org/obo/GO_0048536 GO:1903930 biolink:BiologicalProcess regulation of pyrimidine-containing compound salvage Any process that modulates the frequency, rate or extent of pyrimidine-containing compound salvage. go.json regulation of pyrimidine salvage http://purl.obolibrary.org/obo/GO_1903930 GO:0048535 biolink:BiologicalProcess lymph node development The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. go.json lymph gland development http://purl.obolibrary.org/obo/GO_0048535 GO:0048534 biolink:BiologicalProcess hematopoietic or lymphoid organ development The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. go.json haematopoietic or lymphoid organ development|haemopoietic or lymphoid organ development|hemopoietic or lymphoid organ development http://purl.obolibrary.org/obo/GO_0048534 GO:0048533 biolink:BiologicalProcess sporocyte differentiation The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores. go.json sporocyte development|sporocyte morphogenesis http://purl.obolibrary.org/obo/GO_0048533 GO:0048532 biolink:BiologicalProcess anatomical structure arrangement The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. go.json anatomical structure organization|anatomical structure structural organization|organization of an anatomical structure|structural organization http://purl.obolibrary.org/obo/GO_0048532 GO:0048531 biolink:MolecularActivity beta-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. go.json http://purl.obolibrary.org/obo/GO_0048531 GO:0048539 biolink:BiologicalProcess bone marrow development The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048539 GO:0048541 biolink:BiologicalProcess Peyer's patch development The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. go.json GALT development|gut-associated lymphoid tissue development http://purl.obolibrary.org/obo/GO_0048541 GO:0048540 biolink:BiologicalProcess bursa of Fabricius development The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0048540 GO:1903949 biolink:BiologicalProcess positive regulation of atrial cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential. go.json activation of atrial cardiac muscle cell action potential|up regulation of atrial cardiac muscle cell action potential|up-regulation of atrial cardiac muscle cell action potential|upregulation of atrial cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903949 GO:1903948 biolink:BiologicalProcess negative regulation of atrial cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential. go.json down regulation of atrial cardiac muscle cell action potential|down-regulation of atrial cardiac muscle cell action potential|downregulation of atrial cardiac muscle cell action potential|inhibition of atrial cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903948 GO:1903947 biolink:BiologicalProcess positive regulation of ventricular cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential. go.json activation of ventricular cardiac muscle cell action potential|up regulation of ventricular cardiac muscle cell action potential|up-regulation of ventricular cardiac muscle cell action potential|upregulation of ventricular cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903947 GO:1903946 biolink:BiologicalProcess negative regulation of ventricular cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential. go.json down regulation of ventricular cardiac muscle cell action potential|down-regulation of ventricular cardiac muscle cell action potential|downregulation of ventricular cardiac muscle cell action potential|inhibition of ventricular cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903946 GO:1903945 biolink:BiologicalProcess positive regulation of hepatocyte apoptotic process Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. go.json activation of hepatocyte apoptosis|activation of hepatocyte apoptotic process|positive regulation of hepatocyte apoptosis|up regulation of hepatocyte apoptosis|up regulation of hepatocyte apoptotic process|up-regulation of hepatocyte apoptosis|up-regulation of hepatocyte apoptotic process|upregulation of hepatocyte apoptosis|upregulation of hepatocyte apoptotic process http://purl.obolibrary.org/obo/GO_1903945 GO:1903944 biolink:BiologicalProcess negative regulation of hepatocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. go.json down regulation of hepatocyte apoptosis|down regulation of hepatocyte apoptotic process|down-regulation of hepatocyte apoptosis|down-regulation of hepatocyte apoptotic process|downregulation of hepatocyte apoptosis|downregulation of hepatocyte apoptotic process|inhibition of hepatocyte apoptosis|inhibition of hepatocyte apoptotic process|negative regulation of hepatocyte apoptosis http://purl.obolibrary.org/obo/GO_1903944 GO:0048549 biolink:BiologicalProcess positive regulation of pinocytosis Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. go.json activation of pinocytosis|stimulation of pinocytosis|up regulation of pinocytosis|up-regulation of pinocytosis|upregulation of pinocytosis http://purl.obolibrary.org/obo/GO_0048549 GO:0048548 biolink:BiologicalProcess regulation of pinocytosis Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. go.json http://purl.obolibrary.org/obo/GO_0048548 GO:1903943 biolink:BiologicalProcess regulation of hepatocyte apoptotic process Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. go.json regulation of hepatocyte apoptosis http://purl.obolibrary.org/obo/GO_1903943 GO:1903942 biolink:BiologicalProcess positive regulation of respiratory gaseous exchange Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. go.json activation of respiratory gaseous exchange|up regulation of respiratory gaseous exchange|up-regulation of respiratory gaseous exchange|upregulation of respiratory gaseous exchange http://purl.obolibrary.org/obo/GO_1903942 GO:0048547 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048547 GO:1903941 biolink:BiologicalProcess negative regulation of respiratory gaseous exchange Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. go.json down regulation of respiratory gaseous exchange|down-regulation of respiratory gaseous exchange|downregulation of respiratory gaseous exchange|inhibition of respiratory gaseous exchange http://purl.obolibrary.org/obo/GO_1903941 GO:0048546 biolink:BiologicalProcess digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. go.json alimentary canal morphogenesis|digestive tube morphogenesis|gastrointestinal tract morphogenesis|gut morphogenesis|intestinal morphogenesis http://purl.obolibrary.org/obo/GO_0048546 GO:1903940 biolink:BiologicalProcess negative regulation of TORC2 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling. go.json down regulation of TORC2 signal transduction|down regulation of TORC2 signaling|down-regulation of TORC2 signal transduction|down-regulation of TORC2 signaling|downregulation of TORC2 signal transduction|downregulation of TORC2 signaling|inhibition of TORC2 signal transduction|inhibition of TORC2 signaling|negative regulation of TORC2 signal transduction http://purl.obolibrary.org/obo/GO_1903940 GO:0048545 biolink:BiologicalProcess response to steroid hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. go.json response to steroid hormone stimulus http://purl.obolibrary.org/obo/GO_0048545 GO:0048544 biolink:BiologicalProcess recognition of pollen A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. go.json pollen recognition|recognition or rejection of self pollen|self incompatibility http://purl.obolibrary.org/obo/GO_0048544 GO:0048543 biolink:BiologicalProcess phytochrome chromophore biosynthetic process The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form. go.json phytochrome chromophore anabolism|phytochrome chromophore biosynthesis|phytochrome chromophore formation|phytochrome chromophore synthesis http://purl.obolibrary.org/obo/GO_0048543 GO:0048542 biolink:BiologicalProcess lymph gland development The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. go.json haematopoietic organ development|haemopoietic organ development|hematopoietic organ development|hemopoietic organ development http://purl.obolibrary.org/obo/GO_0048542 GO:0048552 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048552 GO:0048551 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048551 GO:0048550 biolink:BiologicalProcess negative regulation of pinocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. go.json down regulation of pinocytosis|down-regulation of pinocytosis|downregulation of pinocytosis|inhibition of pinocytosis http://purl.obolibrary.org/obo/GO_0048550 GO:1903959 biolink:BiologicalProcess regulation of monoatomic anion transmembrane transport Any process that modulates the frequency, rate or extent of anion transmembrane transport. go.json regulation of anion transmembrane transport http://purl.obolibrary.org/obo/GO_1903959 GO:1903958 biolink:CellularComponent nitric-oxide synthase complex A protein complex which is capable of nitric-oxide synthase activity. go.json iNOS-S100A8/A9 complex http://purl.obolibrary.org/obo/GO_1903958 GO:1903957 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903957 GO:1903956 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903956 GO:1903955 biolink:BiologicalProcess positive regulation of protein targeting to mitochondrion Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion. go.json activation of mitochondrial protein import|activation of mitochondrial translocation|activation of protein import into mitochondrion|activation of protein targeting to mitochondria|activation of protein targeting to mitochondrion|activation of protein-mitochondrial targeting|positive regulation of mitochondrial protein import|positive regulation of mitochondrial translocation|positive regulation of protein import into mitochondrion|positive regulation of protein targeting to mitochondria|positive regulation of protein-mitochondrial targeting|up regulation of mitochondrial protein import|up regulation of mitochondrial translocation|up regulation of protein import into mitochondrion|up regulation of protein targeting to mitochondria|up regulation of protein targeting to mitochondrion|up regulation of protein-mitochondrial targeting|up-regulation of mitochondrial protein import|up-regulation of mitochondrial translocation|up-regulation of protein import into mitochondrion|up-regulation of protein targeting to mitochondria|up-regulation of protein targeting to mitochondrion|up-regulation of protein-mitochondrial targeting|upregulation of mitochondrial protein import|upregulation of mitochondrial translocation|upregulation of protein import into mitochondrion|upregulation of protein targeting to mitochondria|upregulation of protein targeting to mitochondrion|upregulation of protein-mitochondrial targeting http://purl.obolibrary.org/obo/GO_1903955 GO:1903954 biolink:BiologicalProcess positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. go.json activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization http://purl.obolibrary.org/obo/GO_1903954 gocheck_do_not_annotate GO:0048559 biolink:BiologicalProcess establishment of floral organ orientation The process that determines the orientation of the floral organs with reference to the central axis of the flower. go.json http://purl.obolibrary.org/obo/GO_0048559 GO:1903953 biolink:BiologicalProcess negative regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. go.json down regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|down regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|down-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|down-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|downregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|downregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|inhibition of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|inhibition of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|negative regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization http://purl.obolibrary.org/obo/GO_1903953 gocheck_do_not_annotate GO:0048558 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048558 GO:0048557 biolink:BiologicalProcess embryonic digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. go.json embryonic gut morphogenesis http://purl.obolibrary.org/obo/GO_0048557 GO:1903952 biolink:BiologicalProcess regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. go.json regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization http://purl.obolibrary.org/obo/GO_1903952 gocheck_do_not_annotate GO:0048556 biolink:CellularComponent microsporocyte nucleus The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte. go.json microspore mother cell nucleus|pollen mother cell nucleus http://purl.obolibrary.org/obo/GO_0048556 GO:1903951 biolink:BiologicalProcess positive regulation of AV node cell action potential Any process that activates or increases the frequency, rate or extent of AV node cell action potential. go.json activation of AV node cardiac muscle cell action potential|activation of AV node cell action potential|activation of atrioventricular node cardiac muscle cell action potential|positive regulation of AV node cardiac muscle cell action potential|positive regulation of atrioventricular node cardiac muscle cell action potential|up regulation of AV node cardiac muscle cell action potential|up regulation of AV node cell action potential|up regulation of atrioventricular node cardiac muscle cell action potential|up-regulation of AV node cardiac muscle cell action potential|up-regulation of AV node cell action potential|up-regulation of atrioventricular node cardiac muscle cell action potential|upregulation of AV node cardiac muscle cell action potential|upregulation of AV node cell action potential|upregulation of atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903951 GO:1903950 biolink:BiologicalProcess negative regulation of AV node cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. go.json down regulation of AV node cardiac muscle cell action potential|down regulation of AV node cell action potential|down regulation of atrioventricular node cardiac muscle cell action potential|down-regulation of AV node cardiac muscle cell action potential|down-regulation of AV node cell action potential|down-regulation of atrioventricular node cardiac muscle cell action potential|downregulation of AV node cardiac muscle cell action potential|downregulation of AV node cell action potential|downregulation of atrioventricular node cardiac muscle cell action potential|inhibition of AV node cardiac muscle cell action potential|inhibition of AV node cell action potential|inhibition of atrioventricular node cardiac muscle cell action potential|negative regulation of AV node cardiac muscle cell action potential|negative regulation of atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1903950 GO:0048555 biolink:CellularComponent generative cell nucleus The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells. go.json male germ cell nucleus|sperm cell nucleus http://purl.obolibrary.org/obo/GO_0048555 GO:0048554 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048554 GO:0048553 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048553 GO:0048563 biolink:BiologicalProcess obsolete post-embryonic animal organ morphogenesis OBSOLETE. Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json True http://purl.obolibrary.org/obo/GO_0048563 GO:0048562 biolink:BiologicalProcess embryonic organ morphogenesis Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json http://purl.obolibrary.org/obo/GO_0048562 GO:0048561 biolink:BiologicalProcess establishment of animal organ orientation The process that determines the orientation of an animal organ or tissue with reference to an axis. go.json http://purl.obolibrary.org/obo/GO_0048561 GO:0048560 biolink:BiologicalProcess establishment of anatomical structure orientation The process that determines the orientation of an anatomical structure with reference to an axis. go.json http://purl.obolibrary.org/obo/GO_0048560 GO:1903969 biolink:BiologicalProcess regulation of response to macrophage colony-stimulating factor Any process that modulates the frequency, rate or extent of response to macrophage colony-stimulating factor. go.json regulation of response to M-CSF|regulation of response to macrophage colony-stimulating factor stimulus http://purl.obolibrary.org/obo/GO_1903969 GO:1903968 biolink:BiologicalProcess cellular response to micafungin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus. go.json http://purl.obolibrary.org/obo/GO_1903968 GO:1903967 biolink:BiologicalProcess response to micafungin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus. go.json http://purl.obolibrary.org/obo/GO_1903967 GO:1903966 biolink:BiologicalProcess monounsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid. go.json monounsaturated fatty acid anabolism|monounsaturated fatty acid biosynthesis|monounsaturated fatty acid formation|monounsaturated fatty acid synthesis http://purl.obolibrary.org/obo/GO_1903966 GO:1903965 biolink:BiologicalProcess monounsaturated fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of monounsaturated fatty acid. go.json monounsaturated fatty acid breakdown|monounsaturated fatty acid catabolism|monounsaturated fatty acid degradation http://purl.obolibrary.org/obo/GO_1903965 GO:1903964 biolink:BiologicalProcess monounsaturated fatty acid metabolic process The chemical reactions and pathways involving monounsaturated fatty acid. go.json monounsaturated fatty acid metabolism http://purl.obolibrary.org/obo/GO_1903964 GO:0048569 biolink:BiologicalProcess obsolete post-embryonic animal organ development OBSOLETE. Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json post-embryonic animal organogenesis True http://purl.obolibrary.org/obo/GO_0048569 GO:1903963 biolink:BiologicalProcess arachidonate transport The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json arachidonic acid transport http://purl.obolibrary.org/obo/GO_1903963 GO:0048568 biolink:BiologicalProcess embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. go.json embryonic organogenesis http://purl.obolibrary.org/obo/GO_0048568 GO:1903962 biolink:MolecularActivity arachidonate transmembrane transporter activity Enables the transfer of arachidonate from one side of a membrane to the other. go.json arachidonate transporter activity|arachidonic acid transporter activity http://purl.obolibrary.org/obo/GO_1903962 GO:0048567 biolink:BiologicalProcess ectodermal digestive tract morphogenesis The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm. go.json ectodermal gut morphogenesis http://purl.obolibrary.org/obo/GO_0048567 GO:1903961 biolink:BiologicalProcess positive regulation of anion transmembrane transport Any process that activates or increases the frequency, rate or extent of anion transmembrane transport. go.json activation of anion transmembrane transport|up regulation of anion transmembrane transport|up-regulation of anion transmembrane transport|upregulation of anion transmembrane transport http://purl.obolibrary.org/obo/GO_1903961 GO:0048566 biolink:BiologicalProcess embryonic digestive tract development The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. go.json http://purl.obolibrary.org/obo/GO_0048566 GO:0048565 biolink:BiologicalProcess digestive tract development The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. go.json gut development|intestinal development|intestine development http://purl.obolibrary.org/obo/GO_0048565 GO:1903960 biolink:BiologicalProcess negative regulation of anion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport. go.json down regulation of anion transmembrane transport|down-regulation of anion transmembrane transport|downregulation of anion transmembrane transport|inhibition of anion transmembrane transport http://purl.obolibrary.org/obo/GO_1903960 GO:0048564 biolink:BiologicalProcess photosystem I assembly The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane. go.json http://purl.obolibrary.org/obo/GO_0048564 GO:0048574 biolink:BiologicalProcess long-day photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length. go.json long-day photoperiodic control of flowering|long-day photoperiodic control of flowering time|long-day photoperiodic control of inflorescence development|response to long-day, flowering|response to short-night, flowering|short-night photoperiodism, flowering http://purl.obolibrary.org/obo/GO_0048574 GO:0048573 biolink:BiologicalProcess photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species. go.json photoperiodic control of flowering time|photoperiodic control of inflorescence development|response to day length, flowering|response to night length, flowering|response to photoperiod, flowering http://purl.obolibrary.org/obo/GO_0048573 GO:0048572 biolink:BiologicalProcess short-day photoperiodism Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length. go.json long-night photoperiodism|response to long-night|response to short-day|response to short-day photoperiod http://purl.obolibrary.org/obo/GO_0048572 GO:0048571 biolink:BiologicalProcess long-day photoperiodism Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length. go.json response to long-day|response to long-day photoperiod|response to short-night|short-night photoperiodism http://purl.obolibrary.org/obo/GO_0048571 GO:0048570 biolink:BiologicalProcess notochord morphogenesis The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. go.json http://purl.obolibrary.org/obo/GO_0048570 GO:1903979 biolink:BiologicalProcess negative regulation of microglial cell activation Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation. go.json down regulation of microglial cell activation|down-regulation of microglial cell activation|downregulation of microglial cell activation|inhibition of microglial cell activation http://purl.obolibrary.org/obo/GO_1903979 GO:1903978 biolink:BiologicalProcess regulation of microglial cell activation Any process that modulates the frequency, rate or extent of microglial cell activation. go.json http://purl.obolibrary.org/obo/GO_1903978 GO:1903977 biolink:BiologicalProcess positive regulation of glial cell migration Any process that activates or increases the frequency, rate or extent of glial cell migration. go.json activation of glia cell migration|activation of glial cell migration|positive regulation of glia cell migration|up regulation of glia cell migration|up regulation of glial cell migration|up-regulation of glia cell migration|up-regulation of glial cell migration|upregulation of glia cell migration|upregulation of glial cell migration http://purl.obolibrary.org/obo/GO_1903977 GO:1903976 biolink:BiologicalProcess negative regulation of glial cell migration Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. go.json down regulation of glia cell migration|down regulation of glial cell migration|down-regulation of glia cell migration|down-regulation of glial cell migration|downregulation of glia cell migration|downregulation of glial cell migration|inhibition of glia cell migration|inhibition of glial cell migration|negative regulation of glia cell migration http://purl.obolibrary.org/obo/GO_1903976 GO:1903975 biolink:BiologicalProcess regulation of glial cell migration Any process that modulates the frequency, rate or extent of glial cell migration. go.json regulation of glia cell migration http://purl.obolibrary.org/obo/GO_1903975 GO:1903974 biolink:BiologicalProcess positive regulation of cellular response to macrophage colony-stimulating factor stimulus Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus. go.json activation of cellular response to M-CSF stimulus|activation of cellular response to macrophage colony-stimulating factor|activation of cellular response to macrophage colony-stimulating factor stimulus|positive regulation of cellular response to M-CSF stimulus|positive regulation of cellular response to macrophage colony-stimulating factor|up regulation of cellular response to M-CSF stimulus|up regulation of cellular response to macrophage colony-stimulating factor|up regulation of cellular response to macrophage colony-stimulating factor stimulus|up-regulation of cellular response to M-CSF stimulus|up-regulation of cellular response to macrophage colony-stimulating factor|up-regulation of cellular response to macrophage colony-stimulating factor stimulus|upregulation of cellular response to M-CSF stimulus|upregulation of cellular response to macrophage colony-stimulating factor|upregulation of cellular response to macrophage colony-stimulating factor stimulus http://purl.obolibrary.org/obo/GO_1903974 GO:0048579 biolink:BiologicalProcess negative regulation of long-day photoperiodism, flowering Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. go.json down regulation of long-day photoperiodism, flowering|down-regulation of long-day photoperiodism, flowering|downregulation of long-day photoperiodism, flowering|inhibition of long-day photoperiodism, flowering http://purl.obolibrary.org/obo/GO_0048579 GO:1903973 biolink:BiologicalProcess negative regulation of cellular response to macrophage colony-stimulating factor stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus. go.json down regulation of cellular response to M-CSF stimulus|down regulation of cellular response to macrophage colony-stimulating factor|down regulation of cellular response to macrophage colony-stimulating factor stimulus|down-regulation of cellular response to M-CSF stimulus|down-regulation of cellular response to macrophage colony-stimulating factor|down-regulation of cellular response to macrophage colony-stimulating factor stimulus|downregulation of cellular response to M-CSF stimulus|downregulation of cellular response to macrophage colony-stimulating factor|downregulation of cellular response to macrophage colony-stimulating factor stimulus|inhibition of cellular response to M-CSF stimulus|inhibition of cellular response to macrophage colony-stimulating factor|inhibition of cellular response to macrophage colony-stimulating factor stimulus|negative regulation of cellular response to M-CSF stimulus|negative regulation of cellular response to macrophage colony-stimulating factor http://purl.obolibrary.org/obo/GO_1903973 GO:0048578 biolink:BiologicalProcess positive regulation of long-day photoperiodism, flowering Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. go.json activation of long-day photoperiodism, flowering|stimulation of long-day photoperiodism, flowering|up regulation of long-day photoperiodism, flowering|up-regulation of long-day photoperiodism, flowering|upregulation of long-day photoperiodism, flowering http://purl.obolibrary.org/obo/GO_0048578 GO:0048577 biolink:BiologicalProcess negative regulation of short-day photoperiodism, flowering Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. go.json down regulation of short-day photoperiodism, flowering|down-regulation of short-day photoperiodism, flowering|downregulation of short-day photoperiodism, flowering|inhibition of short-day photoperiodism, flowering http://purl.obolibrary.org/obo/GO_0048577 GO:1903972 biolink:BiologicalProcess regulation of cellular response to macrophage colony-stimulating factor stimulus Any process that modulates the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus. go.json regulation of cellular response to M-CSF stimulus|regulation of cellular response to macrophage colony-stimulating factor http://purl.obolibrary.org/obo/GO_1903972 GO:1903971 biolink:BiologicalProcess positive regulation of response to macrophage colony-stimulating factor Any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor. go.json activation of response to M-CSF|activation of response to macrophage colony-stimulating factor|activation of response to macrophage colony-stimulating factor stimulus|positive regulation of response to M-CSF|positive regulation of response to macrophage colony-stimulating factor stimulus|up regulation of response to M-CSF|up regulation of response to macrophage colony-stimulating factor|up regulation of response to macrophage colony-stimulating factor stimulus|up-regulation of response to M-CSF|up-regulation of response to macrophage colony-stimulating factor|up-regulation of response to macrophage colony-stimulating factor stimulus|upregulation of response to M-CSF|upregulation of response to macrophage colony-stimulating factor|upregulation of response to macrophage colony-stimulating factor stimulus http://purl.obolibrary.org/obo/GO_1903971 GO:0048576 biolink:BiologicalProcess positive regulation of short-day photoperiodism, flowering Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. go.json activation of short-day photoperiodism, flowering|stimulation of short-day photoperiodism, flowering|up regulation of short-day photoperiodism, flowering|up-regulation of short-day photoperiodism, flowering|upregulation of short-day photoperiodism, flowering http://purl.obolibrary.org/obo/GO_0048576 GO:0048575 biolink:BiologicalProcess short-day photoperiodism, flowering A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length. go.json long-night photoperiodism, flowering|response to long-night, flowering|response to short-day, flowering|short-day photoperiodic control of flowering|short-day photoperiodic control of flowering time|short-day photoperiodic control of inflorescence development http://purl.obolibrary.org/obo/GO_0048575 GO:1903970 biolink:BiologicalProcess negative regulation of response to macrophage colony-stimulating factor Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor. go.json down regulation of response to M-CSF|down regulation of response to macrophage colony-stimulating factor|down regulation of response to macrophage colony-stimulating factor stimulus|down-regulation of response to M-CSF|down-regulation of response to macrophage colony-stimulating factor|down-regulation of response to macrophage colony-stimulating factor stimulus|downregulation of response to M-CSF|downregulation of response to macrophage colony-stimulating factor|downregulation of response to macrophage colony-stimulating factor stimulus|inhibition of response to M-CSF|inhibition of response to macrophage colony-stimulating factor|inhibition of response to macrophage colony-stimulating factor stimulus|negative regulation of response to M-CSF|negative regulation of response to macrophage colony-stimulating factor stimulus http://purl.obolibrary.org/obo/GO_1903970 GO:1903980 biolink:BiologicalProcess positive regulation of microglial cell activation Any process that activates or increases the frequency, rate or extent of microglial cell activation. go.json activation of microglial cell activation|up regulation of microglial cell activation|up-regulation of microglial cell activation|upregulation of microglial cell activation http://purl.obolibrary.org/obo/GO_1903980 GO:0000721 biolink:MolecularActivity (R,R)-butanediol dehydrogenase activity Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+. EC:1.1.1.4|MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN|RHEA:24340 go.json (R)-2,3-butanediol dehydrogenase activity|(R)-diacetyl reductase activity|1-amino-2-propanol dehydrogenase activity|1-amino-2-propanol oxidoreductase activity|2,3-butanediol dehydrogenase activity|D-(-)-butanediol dehydrogenase activity|D-1-amino-2-propanol dehydrogenase activity|D-1-amino-2-propanol:NAD(2) oxidoreductase activity|D-aminopropanol dehydrogenase activity|D-butanediol dehydrogenase activity|aminopropanol oxidoreductase activity|butylene glycol dehydrogenase activity|butyleneglycol dehydrogenase activity|diacetyl (acetoin) reductase activity http://purl.obolibrary.org/obo/GO_0000721 GO:0000720 biolink:BiologicalProcess pyrimidine dimer repair by nucleotide-excision repair The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. go.json http://purl.obolibrary.org/obo/GO_0000720 GO:0000725 biolink:BiologicalProcess recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. Wikipedia:Recombinational_repair go.json http://purl.obolibrary.org/obo/GO_0000725 GO:0000724 biolink:BiologicalProcess double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. go.json HDR|HRR|Rad51-dependent recombinational repair|Rhp51-dependent recombinational repair|homologous recombinational repair|homology-directed repair http://purl.obolibrary.org/obo/GO_0000724 GO:0000723 biolink:BiologicalProcess telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. go.json regulation of telomere length http://purl.obolibrary.org/obo/GO_0000723 GO:0000722 biolink:BiologicalProcess telomere maintenance via recombination Any recombinational process that contributes to the maintenance of proper telomeric length. go.json telomerase-independent telomere maintenance http://purl.obolibrary.org/obo/GO_0000722 GO:0000729 biolink:BiologicalProcess DNA double-strand break processing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. go.json http://purl.obolibrary.org/obo/GO_0000729 GO:0000728 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000728 GO:0000727 biolink:BiologicalProcess double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. go.json http://purl.obolibrary.org/obo/GO_0000727 GO:0000726 biolink:BiologicalProcess obsolete non-recombinational repair OBSOLETE. A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous DNA region. go.json True http://purl.obolibrary.org/obo/GO_0000726 GO:0000732 biolink:BiologicalProcess DNA strand displacement The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. go.json D-loop dissociation|D-loop processing|displacement loop dissociation|displacement loop processing|strand displacement http://purl.obolibrary.org/obo/GO_0000732 GO:0000731 biolink:BiologicalProcess DNA synthesis involved in DNA repair Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. go.json DNA repair synthesis|DNA synthesis during DNA repair|mitotic DNA repair synthesis http://purl.obolibrary.org/obo/GO_0000731 GO:0000730 biolink:BiologicalProcess DNA recombinase assembly The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA. go.json Rad51 nucleoprotein filament formation http://purl.obolibrary.org/obo/GO_0000730 GO:0000736 biolink:BiologicalProcess double-strand break repair via single-strand annealing, removal of nonhomologous ends During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. go.json http://purl.obolibrary.org/obo/GO_0000736 GO:0000735 biolink:BiologicalProcess removal of nonhomologous ends The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. go.json http://purl.obolibrary.org/obo/GO_0000735 GO:0000734 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000734 GO:0000733 biolink:BiologicalProcess obsolete DNA strand renaturation OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA. go.json True http://purl.obolibrary.org/obo/GO_0000733 GO:0000739 biolink:MolecularActivity obsolete DNA strand annealing activity OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA. go.json DNA strand annealing activity True http://purl.obolibrary.org/obo/GO_0000739 GO:0000738 biolink:BiologicalProcess obsolete DNA catabolic process, exonucleolytic OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. go.json DNA breakdown, exonucleolytic|DNA degradation, exonucleolytic|exonucleolytic degradation of DNA True http://purl.obolibrary.org/obo/GO_0000738 GO:0000737 biolink:BiologicalProcess obsolete DNA catabolic process, endonucleolytic OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. go.json DNA breakdown, endonucleolytic|DNA degradation, endonucleolytic|endonucleolytic DNA catabolism|endonucleolytic degradation of DNA True http://purl.obolibrary.org/obo/GO_0000737 GO:0000709 biolink:BiologicalProcess meiotic joint molecule formation The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA. go.json http://purl.obolibrary.org/obo/GO_0000709 GO:0000708 biolink:BiologicalProcess meiotic strand invasion The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis. go.json meiotic D-loop biosynthesis|meiotic D-loop formation|meiotic displacement loop biosynthesis|meiotic displacement loop formation http://purl.obolibrary.org/obo/GO_0000708 GO:0000703 biolink:MolecularActivity oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Reactome:R-HSA-110224|Reactome:R-HSA-110226|Reactome:R-HSA-110227 go.json DNA glycosylase/AP-lyase|DNA glycosylase/beta-lyase|bifunctional DNA glycosylase|endodeoxyribonuclease III|endonuclease III|endonuclease VIII activity|oxidized pyrimidine base lesion DNA N-glycosylase activity|pyrimidine-specific oxidized base lesion DNA N-glycosylase activity http://purl.obolibrary.org/obo/GO_0000703 GO:0000702 biolink:MolecularActivity oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. go.json http://purl.obolibrary.org/obo/GO_0000702 GO:0000701 biolink:MolecularActivity purine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. EC:3.2.2.31 go.json A/G-specific adenine DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0000701 GO:0000700 biolink:MolecularActivity mismatch base pair DNA N-glycosylase activity Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. go.json http://purl.obolibrary.org/obo/GO_0000700 GO:0000707 biolink:BiologicalProcess meiotic DNA recombinase assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0000707 GO:0000706 biolink:BiologicalProcess meiotic DNA double-strand break processing The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis. go.json http://purl.obolibrary.org/obo/GO_0000706 GO:0000705 biolink:BiologicalProcess achiasmate meiosis I The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata. go.json achiasmate meiosis I nuclear division http://purl.obolibrary.org/obo/GO_0000705 GO:0000704 biolink:MolecularActivity pyrimidine dimer DNA N-glycosylase activity Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. go.json http://purl.obolibrary.org/obo/GO_0000704 GO:0000710 biolink:BiologicalProcess meiotic mismatch repair A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. go.json http://purl.obolibrary.org/obo/GO_0000710 GO:0000719 biolink:BiologicalProcess photoreactive repair The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines. go.json pyrimidine-dimer repair by photolyase http://purl.obolibrary.org/obo/GO_0000719 GO:0000714 biolink:BiologicalProcess meiotic strand displacement The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis. go.json meiotic D-loop dissociation|meiotic D-loop processing|meiotic displacement loop dissociation|meiotic displacement loop processing http://purl.obolibrary.org/obo/GO_0000714 GO:0000713 biolink:BiologicalProcess meiotic heteroduplex formation During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. go.json http://purl.obolibrary.org/obo/GO_0000713 GO:0000712 biolink:BiologicalProcess resolution of meiotic recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. go.json resolution of meiotic joint molecules as recombinants http://purl.obolibrary.org/obo/GO_0000712 GO:0000711 biolink:BiologicalProcess meiotic DNA repair synthesis During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template. go.json http://purl.obolibrary.org/obo/GO_0000711 GO:0000718 biolink:BiologicalProcess nucleotide-excision repair, DNA damage removal The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage. go.json http://purl.obolibrary.org/obo/GO_0000718 GO:0000717 biolink:BiologicalProcess nucleotide-excision repair, DNA duplex unwinding The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. go.json http://purl.obolibrary.org/obo/GO_0000717 GO:0000716 biolink:BiologicalProcess transcription-coupled nucleotide-excision repair, DNA damage recognition The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. go.json pyrimidine-dimer repair, DNA damage recognition http://purl.obolibrary.org/obo/GO_0000716 GO:0000715 biolink:BiologicalProcess nucleotide-excision repair, DNA damage recognition The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. go.json pyrimidine-dimer repair, DNA damage recognition http://purl.obolibrary.org/obo/GO_0000715 GO:0048703 biolink:BiologicalProcess embryonic viscerocranium morphogenesis The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. go.json embryonic pharyngeal skeleton morphogenesis http://purl.obolibrary.org/obo/GO_0048703 GO:0048702 biolink:BiologicalProcess embryonic neurocranium morphogenesis The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain. go.json embryonic braincase morphogenesis|embryonic chondrocranium morphogenesis http://purl.obolibrary.org/obo/GO_0048702 GO:0048701 biolink:BiologicalProcess embryonic cranial skeleton morphogenesis The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. go.json embryonic cranium morphogenesis http://purl.obolibrary.org/obo/GO_0048701 GO:0048700 biolink:BiologicalProcess acquisition of desiccation tolerance in seed The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state. go.json acquisition of desiccation tolerance http://purl.obolibrary.org/obo/GO_0048700 GO:0048709 biolink:BiologicalProcess oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0048709 GO:0048708 biolink:BiologicalProcess astrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. go.json http://purl.obolibrary.org/obo/GO_0048708 GO:0048707 biolink:BiologicalProcess instar larval or pupal morphogenesis The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048707 GO:0048706 biolink:BiologicalProcess embryonic skeletal system development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. go.json embryonic skeletal development http://purl.obolibrary.org/obo/GO_0048706 GO:0048705 biolink:BiologicalProcess skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized. go.json skeletal morphogenesis http://purl.obolibrary.org/obo/GO_0048705 GO:0048704 biolink:BiologicalProcess embryonic skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. go.json embryonic skeletal morphogenesis http://purl.obolibrary.org/obo/GO_0048704 GO:0048714 biolink:BiologicalProcess positive regulation of oligodendrocyte differentiation Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. go.json activation of oligodendrocyte differentiation|stimulation of oligodendrocyte differentiation|up regulation of oligodendrocyte differentiation|up-regulation of oligodendrocyte differentiation|upregulation of oligodendrocyte differentiation http://purl.obolibrary.org/obo/GO_0048714 GO:0048713 biolink:BiologicalProcess regulation of oligodendrocyte differentiation Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0048713 GO:0048712 biolink:BiologicalProcess negative regulation of astrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. go.json down regulation of astrocyte differentiation|down-regulation of astrocyte differentiation|downregulation of astrocyte differentiation|inhibition of astrocyte differentiation http://purl.obolibrary.org/obo/GO_0048712 GO:0048711 biolink:BiologicalProcess positive regulation of astrocyte differentiation Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. go.json activation of astrocyte differentiation|stimulation of astrocyte differentiation|up regulation of astrocyte differentiation|up-regulation of astrocyte differentiation|upregulation of astrocyte differentiation http://purl.obolibrary.org/obo/GO_0048711 GO:0048710 biolink:BiologicalProcess regulation of astrocyte differentiation Any process that modulates the frequency, rate or extent of astrocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0048710 GO:0048719 biolink:BiologicalProcess epistomal sclerite morphogenesis The process in which the anatomical structures of the epistomal sclerite are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048719 GO:0048718 biolink:BiologicalProcess cibarial fish-trap bristle morphogenesis The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium. go.json fish trap bristle morphogenesis http://purl.obolibrary.org/obo/GO_0048718 GO:0048717 biolink:BiologicalProcess anterior cibarial plate morphogenesis The process in which the anatomical structures of the anterior cibarial plate are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048717 GO:0048716 biolink:BiologicalProcess labrum morphogenesis The process in which the anatomical structures of labrum are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048716 GO:0048715 biolink:BiologicalProcess negative regulation of oligodendrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. go.json down regulation of oligodendrocyte differentiation|down-regulation of oligodendrocyte differentiation|downregulation of oligodendrocyte differentiation|inhibition of oligodendrocyte differentiation http://purl.obolibrary.org/obo/GO_0048715 GO:0048725 biolink:BiologicalProcess cibarial fish-trap bristle development The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium. go.json fish-trap bristle development http://purl.obolibrary.org/obo/GO_0048725 GO:0048724 biolink:BiologicalProcess epistomal sclerite development The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048724 GO:0048723 biolink:BiologicalProcess clypeus development The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head. go.json http://purl.obolibrary.org/obo/GO_0048723 GO:0048722 biolink:BiologicalProcess anterior cibarial plate development The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048722 GO:0048721 biolink:BiologicalProcess clypeus morphogenesis The process in which the anatomical structures of the clypeus are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048721 GO:0048720 biolink:BiologicalProcess posterior cibarial plate morphogenesis The process in which the anatomical structures of the posterior cibarial plate are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048720 GO:0048729 biolink:BiologicalProcess tissue morphogenesis The process in which the anatomical structures of a tissue are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048729 GO:0048728 biolink:BiologicalProcess proboscis development The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048728 GO:0048727 biolink:BiologicalProcess posterior cibarial plate development The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048727 GO:0048726 biolink:BiologicalProcess labrum development The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048726 GO:0048736 biolink:BiologicalProcess appendage development The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. go.json http://purl.obolibrary.org/obo/GO_0048736 GO:0048735 biolink:BiologicalProcess haltere morphogenesis The process in which the anatomical structures of a haltere are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048735 GO:0048734 biolink:BiologicalProcess proboscis morphogenesis The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head. go.json http://purl.obolibrary.org/obo/GO_0048734 GO:0048733 biolink:BiologicalProcess sebaceous gland development The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048733 GO:0048732 biolink:BiologicalProcess gland development The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. go.json http://purl.obolibrary.org/obo/GO_0048732 GO:0048731 biolink:BiologicalProcess system development The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. go.json http://purl.obolibrary.org/obo/GO_0048731 goslim_mouse GO:0048730 biolink:BiologicalProcess epidermis morphogenesis The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. go.json hypodermis morphogenesis http://purl.obolibrary.org/obo/GO_0048730 GO:0048739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048739 GO:0048738 biolink:BiologicalProcess cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. go.json heart muscle development http://purl.obolibrary.org/obo/GO_0048738 GO:0048737 biolink:BiologicalProcess imaginal disc-derived appendage development The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. go.json http://purl.obolibrary.org/obo/GO_0048737 GO:0009139 biolink:BiologicalProcess pyrimidine nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. go.json pyrimidine nucleoside diphosphate anabolism|pyrimidine nucleoside diphosphate biosynthesis|pyrimidine nucleoside diphosphate formation|pyrimidine nucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009139 GO:0010128 biolink:BiologicalProcess benzoate catabolic process via CoA ligation The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway. MetaCyc:PWY-283 go.json anaerobic benzoate breakdown|anaerobic benzoate catabolic process|anaerobic benzoate catabolism|anaerobic benzoate degradation http://purl.obolibrary.org/obo/GO_0010128 GO:0010127 biolink:BiologicalProcess mycothiol-dependent detoxification The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell. MetaCyc:PWY1G-1|MetaCyc:PWY1G-170 go.json mycothiol-dependent detoxification of alkylating agent http://purl.obolibrary.org/obo/GO_0010127 GO:0009138 biolink:BiologicalProcess pyrimidine nucleoside diphosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. go.json pyrimidine nucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009138 GO:0009137 biolink:BiologicalProcess purine nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. go.json purine nucleoside diphosphate breakdown|purine nucleoside diphosphate catabolism|purine nucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009137 GO:0009136 biolink:BiologicalProcess purine nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. go.json purine nucleoside diphosphate anabolism|purine nucleoside diphosphate biosynthesis|purine nucleoside diphosphate formation|purine nucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009136 GO:0010129 biolink:BiologicalProcess anaerobic cyclohexane-1-carboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen. MetaCyc:PWY-301 go.json anaerobic cyclohexane-1-carboxylate breakdown|anaerobic cyclohexane-1-carboxylate catabolism|anaerobic cyclohexane-1-carboxylate degradation http://purl.obolibrary.org/obo/GO_0010129 GO:0009135 biolink:BiologicalProcess purine nucleoside diphosphate metabolic process The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. go.json purine nucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009135 GO:0009134 biolink:BiologicalProcess nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. go.json nucleoside diphosphate breakdown|nucleoside diphosphate catabolism|nucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009134 GO:0009133 biolink:BiologicalProcess nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. go.json nucleoside diphosphate anabolism|nucleoside diphosphate biosynthesis|nucleoside diphosphate formation|nucleoside diphosphate synthesis http://purl.obolibrary.org/obo/GO_0009133 GO:0009132 biolink:BiologicalProcess nucleoside diphosphate metabolic process The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. go.json nucleoside diphosphate metabolism http://purl.obolibrary.org/obo/GO_0009132 GO:0010120 biolink:BiologicalProcess camalexin biosynthetic process The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin. MetaCyc:CAMALEXIN-SYN go.json camalexin anabolism|camalexin biosynthesis|camalexin formation|camalexin synthesis http://purl.obolibrary.org/obo/GO_0010120 GO:0009142 biolink:BiologicalProcess nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. go.json nucleoside triphosphate anabolism|nucleoside triphosphate biosynthesis|nucleoside triphosphate formation|nucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009142 GO:0009141 biolink:BiologicalProcess nucleoside triphosphate metabolic process The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. go.json nucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009141 GO:0010122 biolink:BiologicalProcess arginine catabolic process to alanine via ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine. go.json arginine breakdown to alanine via ornithine|arginine degradation to alanine via ornithine http://purl.obolibrary.org/obo/GO_0010122 GO:0009140 biolink:BiologicalProcess pyrimidine nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. go.json pyrimidine nucleoside diphosphate breakdown|pyrimidine nucleoside diphosphate catabolism|pyrimidine nucleoside diphosphate degradation http://purl.obolibrary.org/obo/GO_0009140 GO:0010121 biolink:BiologicalProcess arginine catabolic process to proline via ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine. go.json arginine breakdown to proline via ornithine|arginine degradation to proline via ornithine http://purl.obolibrary.org/obo/GO_0010121 GO:0010124 biolink:BiologicalProcess phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate. MetaCyc:PWY0-321 go.json phenylacetate breakdown|phenylacetate catabolism|phenylacetate degradation http://purl.obolibrary.org/obo/GO_0010124 GO:0010123 biolink:BiologicalProcess obsolete acetate catabolic process to butyrate, ethanol, acetone and butanol OBSOLETE. The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol. MetaCyc:CENTFERM-PWY go.json acetate fermentation to butyrate, ethanol, acetone and butanol True http://purl.obolibrary.org/obo/GO_0010123 GO:0010126 biolink:BiologicalProcess mycothiol metabolic process The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione. go.json mycothiol metabolism http://purl.obolibrary.org/obo/GO_0010126 GO:0010125 biolink:BiologicalProcess mycothiol biosynthetic process The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione. MetaCyc:PWY1G-0 go.json mycothiol anabolism|mycothiol biosynthesis|mycothiol formation|mycothiol synthesis http://purl.obolibrary.org/obo/GO_0010125 GO:0010139 biolink:BiologicalProcess pyrimidine deoxyribonucleotide salvage The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis. MetaCyc:PWY-7199 go.json http://purl.obolibrary.org/obo/GO_0010139 GO:0009149 biolink:BiologicalProcess pyrimidine nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. go.json pyrimidine nucleoside triphosphate breakdown|pyrimidine nucleoside triphosphate catabolism|pyrimidine nucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009149 GO:0010138 biolink:BiologicalProcess pyrimidine ribonucleotide salvage The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0010138 GO:0009148 biolink:BiologicalProcess pyrimidine nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. go.json pyrimidine nucleoside triphosphate anabolism|pyrimidine nucleoside triphosphate biosynthesis|pyrimidine nucleoside triphosphate formation|pyrimidine nucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009148 GO:0009147 biolink:BiologicalProcess pyrimidine nucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. go.json pyrimidine nucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009147 GO:0009146 biolink:BiologicalProcess purine nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. go.json purine nucleoside triphosphate breakdown|purine nucleoside triphosphate catabolism|purine nucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009146 GO:0009145 biolink:BiologicalProcess purine nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. go.json purine nucleoside triphosphate anabolism|purine nucleoside triphosphate biosynthesis|purine nucleoside triphosphate formation|purine nucleoside triphosphate synthesis http://purl.obolibrary.org/obo/GO_0009145 GO:0009144 biolink:BiologicalProcess purine nucleoside triphosphate metabolic process The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. go.json purine nucleoside triphosphate metabolism http://purl.obolibrary.org/obo/GO_0009144 GO:0009143 biolink:BiologicalProcess nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. go.json nucleoside triphosphate breakdown|nucleoside triphosphate catabolism|nucleoside triphosphate degradation http://purl.obolibrary.org/obo/GO_0009143 GO:0009153 biolink:BiologicalProcess purine deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine deoxyribonucleotide anabolism|purine deoxyribonucleotide biosynthesis|purine deoxyribonucleotide formation|purine deoxyribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009153 GO:0010131 biolink:BiologicalProcess obsolete sucrose catabolic process, using invertase or sucrose synthase OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase. MetaCyc:PWY-3801|MetaCyc:PWY-621 go.json sucrose breakdown, using invertase or sucrose synthase|sucrose catabolic process, using invertase or sucrose synthase|sucrose catabolism, using invertase or sucrose synthase|sucrose degradation, using invertase or sucrose synthase True http://purl.obolibrary.org/obo/GO_0010131 GO:0010130 biolink:BiologicalProcess anaerobic ethylbenzene catabolic process The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen. MetaCyc:PWY-481 go.json anaerobic ethylbenzene breakdown|anaerobic ethylbenzene catabolism|anaerobic ethylbenzene degradation http://purl.obolibrary.org/obo/GO_0010130 GO:0009152 biolink:BiologicalProcess purine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine ribonucleotide anabolism|purine ribonucleotide biosynthesis|purine ribonucleotide formation|purine ribonucleotide synthesis http://purl.obolibrary.org/obo/GO_0009152 GO:0010133 biolink:BiologicalProcess proline catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. MetaCyc:PROUT-PWY go.json proline breakdown to glutamate|proline degradation to glutamate|proline oxidation http://purl.obolibrary.org/obo/GO_0010133 GO:0009151 biolink:BiologicalProcess purine deoxyribonucleotide metabolic process The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine deoxyribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009151 GO:0010132 biolink:BiologicalProcess dhurrin biosynthetic process The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound. MetaCyc:PWY-861 go.json dhurrin anabolism|dhurrin biosynthesis|dhurrin formation|dhurrin synthesis http://purl.obolibrary.org/obo/GO_0010132 GO:0009150 biolink:BiologicalProcess purine ribonucleotide metabolic process The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. go.json purine ribonucleotide metabolism http://purl.obolibrary.org/obo/GO_0009150 GO:0010135 biolink:BiologicalProcess ureide metabolic process The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants. go.json ureide metabolism http://purl.obolibrary.org/obo/GO_0010135 GO:0010134 biolink:BiologicalProcess sulfate assimilation via adenylyl sulfate reduction The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase. MetaCyc:SULFMETII-PWY go.json sulphate assimilation via adenylyl sulphate reduction http://purl.obolibrary.org/obo/GO_0010134 GO:0010137 biolink:BiologicalProcess ureide biosynthetic process The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots. MetaCyc:URSIN-PWY go.json ureide anabolism|ureide biosynthesis|ureide formation|ureide synthesis http://purl.obolibrary.org/obo/GO_0010137 GO:0010136 biolink:BiologicalProcess ureide catabolic process The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium. MetaCyc:URDEGR-PWY go.json ureide breakdown|ureide catabolism|ureide degradation http://purl.obolibrary.org/obo/GO_0010136 GO:0000783 biolink:CellularComponent nuclear telomere cap complex A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. go.json http://purl.obolibrary.org/obo/GO_0000783 GO:0097695 biolink:BiologicalProcess establishment of protein-containing complex localization to telomere The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome. go.json establishment of macromolecular complex localisation to telomere|establishment of macromolecular complex localization to telomere http://purl.obolibrary.org/obo/GO_0097695 GO:0000782 biolink:CellularComponent telomere cap complex A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. go.json http://purl.obolibrary.org/obo/GO_0000782 goslim_pir GO:0097694 biolink:BiologicalProcess establishment of RNA localization to telomere The directed movement of RNA to a specific location in the telomeric region of a chromosome. go.json establishment of RNA localisation to telomere http://purl.obolibrary.org/obo/GO_0097694 GO:0097697 biolink:MolecularActivity tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine. RHEA:54080 go.json tRNA 5-carboxymethoxyuridine methyltransferase activity http://purl.obolibrary.org/obo/GO_0097697 GO:0000781 biolink:CellularComponent chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). SO:0000624 go.json nuclear chromosome, telomere|nuclear chromosome, telomeric region|telomere http://purl.obolibrary.org/obo/GO_0000781 GO:0000780 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000780 GO:0097696 biolink:BiologicalProcess receptor signaling pathway via STAT An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. go.json STAT signalling pathway|kinase activated-STAT cascade|kinase-STAT cascade http://purl.obolibrary.org/obo/GO_0097696 GO:0097691 biolink:CellularComponent bacterial extracellular vesicle Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells. go.json http://purl.obolibrary.org/obo/GO_0097691 GO:0000787 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000787 GO:0000786 biolink:CellularComponent nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. Wikipedia:Nucleosome go.json cytoplasmic nucleosome|nuclear nucleosome http://purl.obolibrary.org/obo/GO_0000786 goslim_pir GO:0097690 biolink:MolecularActivity iron ion transmembrane transporter inhibitor activity Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter. go.json iron channel inhibitor activity http://purl.obolibrary.org/obo/GO_0097690 GO:0009119 biolink:BiologicalProcess ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json ribonucleoside metabolism http://purl.obolibrary.org/obo/GO_0009119 GO:0000785 biolink:CellularComponent chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. NIF_Subcellular:sao1615953555 go.json chromosome scaffold|cytoplasmic chromatin|nuclear chromatin http://purl.obolibrary.org/obo/GO_0000785 GO:0097693 biolink:CellularComponent ocelloid Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids. go.json http://purl.obolibrary.org/obo/GO_0097693 GO:0009118 biolink:BiologicalProcess regulation of nucleoside metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. go.json regulation of nucleoside metabolism http://purl.obolibrary.org/obo/GO_0009118 GO:0097692 biolink:BiologicalProcess histone H3-K4 monomethylation The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone. go.json http://purl.obolibrary.org/obo/GO_0097692 gocheck_do_not_annotate GO:0000784 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000784 GO:0010106 biolink:BiologicalProcess cellular response to iron ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions. go.json http://purl.obolibrary.org/obo/GO_0010106 GO:0009117 biolink:BiologicalProcess nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). go.json nucleotide metabolism http://purl.obolibrary.org/obo/GO_0009117 goslim_pir GO:0010105 biolink:BiologicalProcess negative regulation of ethylene-activated signaling pathway Any process that stops or prevents ethylene (ethene) signal transduction. go.json down regulation of ethylene mediated signaling pathway|down-regulation of ethylene mediated signaling pathway|downregulation of ethylene mediated signaling pathway|inhibition of ethylene mediated signaling pathway|negative regulation of ethene mediated signaling pathway|negative regulation of ethene mediated signalling pathway|negative regulation of ethylene mediated signaling pathway|negative regulation of ethylene mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010105 GO:0009116 biolink:BiologicalProcess nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). go.json nucleoside metabolism http://purl.obolibrary.org/obo/GO_0009116 goslim_pir GO:0010108 biolink:BiologicalProcess obsolete detection of glutamine OBSOLETE. The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal. go.json glutamine detection|glutamine perception|glutamine sensing True http://purl.obolibrary.org/obo/GO_0010108 GO:0009115 biolink:BiologicalProcess xanthine catabolic process The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. go.json xanthine breakdown|xanthine catabolism|xanthine degradation|xanthine oxidation http://purl.obolibrary.org/obo/GO_0009115 GO:0009114 biolink:BiologicalProcess hypoxanthine catabolic process The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. go.json hypoxanthine breakdown|hypoxanthine catabolism|hypoxanthine degradation|hypoxanthine oxidation http://purl.obolibrary.org/obo/GO_0009114 GO:0010107 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0010107 GO:0009113 biolink:BiologicalProcess purine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. MetaCyc:PWY-841 go.json purine base anabolism|purine base biosynthesis|purine base biosynthetic process|purine base formation|purine base synthesis http://purl.obolibrary.org/obo/GO_0009113 GO:0010109 biolink:BiologicalProcess regulation of photosynthesis Any process that modulates the frequency, rate or extent of photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0010109 GO:0009112 biolink:BiologicalProcess nucleobase metabolic process The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. go.json nucleobase metabolism http://purl.obolibrary.org/obo/GO_0009112 GO:0009111 biolink:BiologicalProcess vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json vitamin breakdown|vitamin catabolism|vitamin degradation http://purl.obolibrary.org/obo/GO_0009111 GO:0009110 biolink:BiologicalProcess vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json vitamin anabolism|vitamin biosynthesis|vitamin formation|vitamin synthesis http://purl.obolibrary.org/obo/GO_0009110 GO:0009120 biolink:BiologicalProcess deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json deoxyribonucleoside metabolism http://purl.obolibrary.org/obo/GO_0009120 GO:0010100 biolink:BiologicalProcess negative regulation of photomorphogenesis Any process that stops, reduces or prevents photomorphogenesis. go.json down regulation of photomorphogenesis|down-regulation of photomorphogenesis|downregulation of photomorphogenesis|inhibition of photomorphogenesis http://purl.obolibrary.org/obo/GO_0010100 GO:0010102 biolink:BiologicalProcess lateral root morphogenesis The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. go.json http://purl.obolibrary.org/obo/GO_0010102 GO:0010101 biolink:BiologicalProcess post-embryonic root morphogenesis The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed. go.json http://purl.obolibrary.org/obo/GO_0010101 GO:0010104 biolink:BiologicalProcess regulation of ethylene-activated signaling pathway Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction. go.json regulation of ethene mediated signaling pathway|regulation of ethene mediated signalling pathway|regulation of ethylene mediated signaling pathway|regulation of ethylene mediated signalling pathway http://purl.obolibrary.org/obo/GO_0010104 GO:0010103 biolink:BiologicalProcess stomatal complex morphogenesis The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells. go.json http://purl.obolibrary.org/obo/GO_0010103 GO:0000789 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000789 GO:0000788 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000788 GO:0097699 biolink:BiologicalProcess vascular endothelial cell response to fluid shear stress Any response to fluid shear stress in a vascular endothelial cell. go.json blood vessel endothelial cell response to fluid shear stress http://purl.obolibrary.org/obo/GO_0097699 GO:0097698 biolink:BiologicalProcess telomere maintenance via base-excision repair A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature. go.json http://purl.obolibrary.org/obo/GO_0097698 GO:0000794 biolink:CellularComponent condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. go.json meiotic chromosome|nuclear mitotic chromosome http://purl.obolibrary.org/obo/GO_0000794 GO:0000793 biolink:CellularComponent condensed chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. go.json cytoplasmic mitotic chromosome|metaphase chromosome|mitotic chromosome http://purl.obolibrary.org/obo/GO_0000793 GO:0000792 biolink:CellularComponent heterochromatin A compact and highly condensed form of chromatin that is refractory to transcription. NIF_Subcellular:sao581845896|Wikipedia:Heterochromatin go.json nuclear heterochromatin|transcriptionally inactive chromatin|transcriptionally silent chromatin http://purl.obolibrary.org/obo/GO_0000792 GO:0000791 biolink:CellularComponent euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. NIF_Subcellular:sao445485807|Wikipedia:Euchromatin go.json nuclear euchromatin|transcriptionally active chromatin http://purl.obolibrary.org/obo/GO_0000791 GO:0000798 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000798 GO:0000797 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000797 GO:0000796 biolink:CellularComponent condensin complex A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis. go.json 13S condensin complex|8S condensin complex|SMC complex|Smc2-Smc4 complex|condensin I complex|condensin core heterodimer|nuclear condensin complex http://purl.obolibrary.org/obo/GO_0000796 goslim_pir GO:0009129 biolink:BiologicalProcess pyrimidine nucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. go.json pyrimidine nucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009129 GO:0000795 biolink:CellularComponent synaptonemal complex A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element. Wikipedia:Synaptonemal_complex go.json http://purl.obolibrary.org/obo/GO_0000795 GO:0009128 biolink:BiologicalProcess purine nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. go.json purine nucleoside monophosphate breakdown|purine nucleoside monophosphate catabolism|purine nucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009128 GO:0010117 biolink:BiologicalProcess photoprotection Protection mechanism used by plants and cyanobacteria under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0010117 GO:0010116 biolink:BiologicalProcess positive regulation of abscisic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. go.json activation of abscisic acid biosynthetic process|positive regulation of abscisic acid anabolism|positive regulation of abscisic acid biosynthesis|positive regulation of abscisic acid formation|positive regulation of abscisic acid synthesis|stimulation of abscisic acid biosynthetic process|up regulation of abscisic acid biosynthetic process|up-regulation of abscisic acid biosynthetic process|upregulation of abscisic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0010116 GO:0009127 biolink:BiologicalProcess purine nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. go.json purine nucleoside monophosphate anabolism|purine nucleoside monophosphate biosynthesis|purine nucleoside monophosphate formation|purine nucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009127 GO:0010119 biolink:BiologicalProcess regulation of stomatal movement Any process that modulates the frequency, rate or extent of stomatal movement. go.json http://purl.obolibrary.org/obo/GO_0010119 GO:0009126 biolink:BiologicalProcess purine nucleoside monophosphate metabolic process The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. go.json purine nucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009126 GO:0009125 biolink:BiologicalProcess nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. go.json nucleoside monophosphate breakdown|nucleoside monophosphate catabolism|nucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009125 GO:0010118 biolink:BiologicalProcess stomatal movement The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata). go.json http://purl.obolibrary.org/obo/GO_0010118 goslim_pir GO:0009124 biolink:BiologicalProcess nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. go.json nucleoside monophosphate anabolism|nucleoside monophosphate biosynthesis|nucleoside monophosphate formation|nucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009124 GO:0000790 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000790 GO:0009123 biolink:BiologicalProcess nucleoside monophosphate metabolic process The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. go.json nucleoside monophosphate metabolism http://purl.obolibrary.org/obo/GO_0009123 GO:0009122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009122 GO:0009121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009121 GO:0009131 biolink:BiologicalProcess pyrimidine nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. go.json pyrimidine nucleoside monophosphate breakdown|pyrimidine nucleoside monophosphate catabolism|pyrimidine nucleoside monophosphate degradation http://purl.obolibrary.org/obo/GO_0009131 GO:0009130 biolink:BiologicalProcess pyrimidine nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. go.json pyrimidine nucleoside monophosphate anabolism|pyrimidine nucleoside monophosphate biosynthesis|pyrimidine nucleoside monophosphate formation|pyrimidine nucleoside monophosphate synthesis http://purl.obolibrary.org/obo/GO_0009130 GO:0010111 biolink:BiologicalProcess glyoxysome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway. go.json glyoxysome organisation|glyoxysome organization and biogenesis http://purl.obolibrary.org/obo/GO_0010111 GO:0010110 biolink:BiologicalProcess regulation of photosynthesis, dark reaction Any process that modulates the frequency, rate or extent of photosynthesis dark reaction. go.json http://purl.obolibrary.org/obo/GO_0010110 GO:0010113 biolink:BiologicalProcess negative regulation of systemic acquired resistance Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance. go.json down regulation of systemic acquired resistance|down-regulation of systemic acquired resistance|downregulation of systemic acquired resistance|inhibition of systemic acquired resistance http://purl.obolibrary.org/obo/GO_0010113 GO:0010112 biolink:BiologicalProcess regulation of systemic acquired resistance Any process that modulates the frequency, rate or extent of systemic acquired resistance. go.json http://purl.obolibrary.org/obo/GO_0010112 GO:0010115 biolink:BiologicalProcess regulation of abscisic acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. go.json regulation of abscisic acid anabolism|regulation of abscisic acid biosynthesis|regulation of abscisic acid formation|regulation of abscisic acid synthesis http://purl.obolibrary.org/obo/GO_0010115 GO:0010114 biolink:BiologicalProcess response to red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json response to red light stimulus http://purl.obolibrary.org/obo/GO_0010114 GO:0000799 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000799 GO:0000761 biolink:BiologicalProcess conjugant formation During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing. go.json http://purl.obolibrary.org/obo/GO_0000761 GO:0000760 biolink:BiologicalProcess adaptation to pheromone regulating conjugation with mutual genetic exchange In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. go.json adaptation to pheromone involved conjugation without cellular fusion|desensitization to pheromone during conjugation without cellular fusion http://purl.obolibrary.org/obo/GO_0000760 GO:0000765 biolink:BiologicalProcess response to pheromone regulating pheromone-induced unidirectional conjugation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation. go.json response to pheromone during pheromone-induced unidirectional http://purl.obolibrary.org/obo/GO_0000765 GO:0000764 biolink:BiologicalProcess obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation. go.json cellular morphogenesis during pheromone-induced unidirectional|cellular morphogenesis involved in pheromone-induced unidirectional conjugation True http://purl.obolibrary.org/obo/GO_0000764 GO:0000763 biolink:BiologicalProcess obsolete cell morphogenesis involved in unidirectional conjugation OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation. go.json cell morphogenesis involved in unidirectional conjugation True http://purl.obolibrary.org/obo/GO_0000763 GO:0000762 biolink:BiologicalProcess pheromone-induced unidirectional conjugation Unidirectional transfer of genetic information triggered by to a pheromone signal. go.json http://purl.obolibrary.org/obo/GO_0000762 GO:0000769 biolink:BiologicalProcess syncytium formation by mitosis without cytokinesis The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis. go.json syncytium formation by mitosis without cell division http://purl.obolibrary.org/obo/GO_0000769 GO:0000768 biolink:BiologicalProcess syncytium formation by plasma membrane fusion The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. go.json cell fusion http://purl.obolibrary.org/obo/GO_0000768 GO:0000767 biolink:BiologicalProcess obsolete cell morphogenesis involved in conjugation OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types. go.json True http://purl.obolibrary.org/obo/GO_0000767 GO:0000766 biolink:BiologicalProcess negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses. go.json adaptation to pheromone during pheromone-induced unidirectional conjugation|desensitization to pheromone during pheromone-induced unidirectional conjugation|negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation http://purl.obolibrary.org/obo/GO_0000766 GO:0000772 biolink:MolecularActivity mating pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted. go.json http://purl.obolibrary.org/obo/GO_0000772 GO:0000771 biolink:BiologicalProcess obsolete agglutination involved in conjugation OBSOLETE. The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation. go.json True http://purl.obolibrary.org/obo/GO_0000771 GO:0000770 biolink:BiologicalProcess peptide pheromone export The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones. go.json a-factor export http://purl.obolibrary.org/obo/GO_0000770 GO:0000776 biolink:CellularComponent kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. Wikipedia:Kinetochore go.json NMS complex|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore http://purl.obolibrary.org/obo/GO_0000776 goslim_pir GO:0000775 biolink:CellularComponent chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. SO:0000577 go.json centromere|centromere complex|chromosome, centric region|chromosome, pericentric region http://purl.obolibrary.org/obo/GO_0000775 GO:0009109 biolink:BiologicalProcess obsolete coenzyme catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. go.json coenzyme and prosthetic group catabolic process|coenzyme and prosthetic group catabolism|coenzyme breakdown|coenzyme catabolism|coenzyme degradation True http://purl.obolibrary.org/obo/GO_0009109 GO:0009108 biolink:BiologicalProcess obsolete coenzyme biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. go.json coenzyme anabolism|coenzyme and prosthetic group biosynthesis|coenzyme and prosthetic group biosynthetic process|coenzyme biosynthesis|coenzyme formation|coenzyme synthesis True http://purl.obolibrary.org/obo/GO_0009108 GO:0000774 biolink:MolecularActivity adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. Reactome:R-HSA-5252079 go.json http://purl.obolibrary.org/obo/GO_0000774 GO:0009107 biolink:BiologicalProcess lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. go.json lipoate anabolism|lipoate biosynthesis|lipoate formation|lipoate synthesis|lipoic acid anabolism|lipoic acid biosynthesis|lipoic acid biosynthetic process|lipoic acid formation|lipoic acid synthesis http://purl.obolibrary.org/obo/GO_0009107 GO:0000773 biolink:MolecularActivity phosphatidyl-N-methylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. EC:2.1.1.71|MetaCyc:2.1.1.71-RXN|RHEA:32735 go.json PLMT|S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity|methyltransferase II|phosphatidyl-N-methylethanolamine methyltransferase activity|phosphatidyl-N-monomethylethanolamine methyltransferase activity|phosphatidylethanolamine methyltransferase I|phosphatidylmonomethylethanolamine methyltransferase activity|phospholipid methyltransferase activity http://purl.obolibrary.org/obo/GO_0000773 GO:0009106 biolink:BiologicalProcess lipoate metabolic process The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. go.json lipoate metabolism|lipoic acid metabolic process|lipoic acid metabolism http://purl.obolibrary.org/obo/GO_0009106 GO:0009105 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009105 GO:0009104 biolink:BiologicalProcess lipopolysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. go.json LPS catabolic process|lipopolysaccharide breakdown|lipopolysaccharide catabolism|lipopolysaccharide degradation http://purl.obolibrary.org/obo/GO_0009104 GO:0009103 biolink:BiologicalProcess lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. KEGG_PATHWAY:map00540 go.json LPS biosynthetic process|lipopolysaccharide anabolism|lipopolysaccharide biosynthesis|lipopolysaccharide formation|lipopolysaccharide synthesis http://purl.obolibrary.org/obo/GO_0009103 GO:0009102 biolink:BiologicalProcess biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. MetaCyc:BIOTIN-SYN go.json biotin anabolism|biotin biosynthesis|biotin formation|biotin synthesis|vitamin B7 biosynthesis|vitamin B7 biosynthetic process|vitamin H biosynthesis|vitamin H biosynthetic process http://purl.obolibrary.org/obo/GO_0009102 GO:0009101 biolink:BiologicalProcess glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. go.json glycoprotein anabolism|glycoprotein biosynthesis|glycoprotein formation|glycoprotein synthesis http://purl.obolibrary.org/obo/GO_0009101 GO:0009100 biolink:BiologicalProcess glycoprotein metabolic process The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. go.json glycoprotein metabolism http://purl.obolibrary.org/obo/GO_0009100 goslim_drosophila GO:0000779 biolink:CellularComponent condensed chromosome, centromeric region The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. go.json condensed chromosome, centric region|condensed chromosome, centromere|condensed chromosome, pericentric region|condensed nuclear chromosome, centromeric region http://purl.obolibrary.org/obo/GO_0000779 GO:0000778 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000778 GO:0000777 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0000777 GO:0000743 biolink:BiologicalProcess nuclear migration involved in conjugation with cellular fusion The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion. go.json nuclear congression|nuclear migration during conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0000743 GO:0000742 biolink:BiologicalProcess karyogamy involved in conjugation with cellular fusion During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy. go.json karyogamy during conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0000742 GO:0000741 biolink:BiologicalProcess karyogamy The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. Wikipedia:Karyogamy go.json nuclear fusion|nuclear fusion during karyogamy http://purl.obolibrary.org/obo/GO_0000741 GO:0000740 biolink:BiologicalProcess nuclear membrane fusion The joining of 2 or more lipid bilayer membranes that surround the nucleus. go.json http://purl.obolibrary.org/obo/GO_0000740 GO:0000747 biolink:BiologicalProcess conjugation with cellular fusion A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae. Wikipedia:Conjugation go.json cell fusion|mating http://purl.obolibrary.org/obo/GO_0000747 goslim_candida|goslim_pir|goslim_pombe|goslim_yeast GO:0000746 biolink:BiologicalProcess obsolete conjugation OBSOLETE. The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms. Wikipedia:Conjugation go.json True http://purl.obolibrary.org/obo/GO_0000746 GO:0000745 biolink:BiologicalProcess nuclear migration involved in conjugation with mutual genetic exchange The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion. go.json nuclear exchange during conjugation without cellular fusion|nuclear migration involved in conjugation without cellular fusion http://purl.obolibrary.org/obo/GO_0000745 GO:0000744 biolink:BiologicalProcess karyogamy involved in conjugation with mutual genetic exchange During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena. go.json karyogamy involved in conjugation without cellular fusion http://purl.obolibrary.org/obo/GO_0000744 GO:0000749 biolink:BiologicalProcess response to pheromone triggering conjugation with cellular fusion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. go.json response to pheromone during conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0000749 GO:0000748 biolink:BiologicalProcess conjugation with mutual genetic exchange A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange. go.json conjugation without cellular fusion http://purl.obolibrary.org/obo/GO_0000748 GO:0000750 biolink:BiologicalProcess pheromone-dependent signal transduction involved in conjugation with cellular fusion A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. go.json transduction of mating signal http://purl.obolibrary.org/obo/GO_0000750 GO:0000754 biolink:BiologicalProcess adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae. go.json adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion|adaptation to pheromone during conjugation with cellular fusion|desensitization to pheromone during conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0000754 GO:0000753 biolink:BiologicalProcess cell morphogenesis involved in conjugation with cellular fusion The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion. go.json shmoo orientation|shmooing http://purl.obolibrary.org/obo/GO_0000753 GO:0000752 biolink:BiologicalProcess agglutination involved in conjugation with cellular fusion The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae. go.json agglutination|cell-cell adhesion during conjugation with cellular fusion|cell-cell adhesion during mating http://purl.obolibrary.org/obo/GO_0000752 GO:0000751 biolink:BiologicalProcess mitotic cell cycle G1 arrest in response to pheromone The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae. go.json cell cycle arrest in response to pheromone http://purl.obolibrary.org/obo/GO_0000751 GO:0000758 biolink:BiologicalProcess agglutination involved in conjugation with mutual genetic exchange The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism. go.json agglutination involved in conjugation without cellular fusion|sexual flocculation http://purl.obolibrary.org/obo/GO_0000758 GO:0000757 biolink:BiologicalProcess obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion. go.json signal transduction involved in conjugation without cellular fusion True http://purl.obolibrary.org/obo/GO_0000757 GO:0000756 biolink:BiologicalProcess response to pheromone regulating conjugation with mutual genetic exchange Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion. go.json response to pheromone triggering conjugation without cellular fusion http://purl.obolibrary.org/obo/GO_0000756 GO:0000755 biolink:BiologicalProcess cytogamy During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae. go.json zygote formation http://purl.obolibrary.org/obo/GO_0000755 GO:0000759 biolink:BiologicalProcess obsolete cell morphogenesis involved in conjugation with mutual genetic exchange OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion. go.json cellular morphogenesis involved in conjugation without cellular fusion True http://purl.obolibrary.org/obo/GO_0000759 GO:0097631 biolink:CellularComponent obsolete integral component of omegasome membrane OBSOLETE. The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to omegasome membrane|omegasome integral membrane protein True http://purl.obolibrary.org/obo/GO_0097631 GO:0097630 biolink:CellularComponent obsolete intrinsic component of omegasome membrane OBSOLETE. The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to omegasome membrane True http://purl.obolibrary.org/obo/GO_0097630 GO:1903869 biolink:BiologicalProcess negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity. go.json down regulation of 5,10-CH(2)-H(4)folate reductase activity|down regulation of 5,10-CH2-H4folate reductase activity|down regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|down regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|down regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|down regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|down regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|down regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|down regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|down regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|down regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|down regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|down regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|down regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|down regulation of MetF|down regulation of N5,10-methylenetetrahydrofolate reductase activity|down regulation of N5,N10-methylenetetrahydrofolate reductase activity|down regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|down regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|down regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity|down regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|down regulation of methylenetetrahydrofolate reductase (NADPH2)|down regulation of methylenetetrahydrofolate reductase [NAD(P)H]|down-regulation of 5,10-CH(2)-H(4)folate reductase activity|down-regulation of 5,10-CH2-H4folate reductase activity|down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|down-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|down-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|down-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|down-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|down-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|down-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|down-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|down-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|down-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|down-regulation of MetF|down-regulation of N5,10-methylenetetrahydrofolate reductase activity|down-regulation of N5,N10-methylenetetrahydrofolate reductase activity|down-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|down-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|down-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity|down-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|down-regulation of methylenetetrahydrofolate reductase (NADPH2)|down-regulation of methylenetetrahydrofolate reductase [NAD(P)H]|downregulation of 5,10-CH(2)-H(4)folate reductase activity|downregulation of 5,10-CH2-H4folate reductase activity|downregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|downregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|downregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|downregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|downregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|downregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|downregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|downregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|downregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|downregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|downregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|downregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|downregulation of MetF|downregulation of N5,10-methylenetetrahydrofolate reductase activity|downregulation of N5,N10-methylenetetrahydrofolate reductase activity|downregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|downregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|downregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity|downregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|downregulation of methylenetetrahydrofolate reductase (NADPH2)|downregulation of methylenetetrahydrofolate reductase [NAD(P)H]|inhibition of 5,10-CH(2)-H(4)folate reductase activity|inhibition of 5,10-CH2-H4folate reductase activity|inhibition of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|inhibition of 5,10-methylenetetrahydrofolate reductase (FADH) activity|inhibition of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|inhibition of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|inhibition of 5,10-methylenetetrahydropteroylglutamate reductase activity|inhibition of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|inhibition of 5-methyltetrahydrofolate:NAD oxidoreductase activity|inhibition of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|inhibition of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|inhibition of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|inhibition of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|inhibition of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|inhibition of MetF|inhibition of N5,10-methylenetetrahydrofolate reductase activity|inhibition of N5,N10-methylenetetrahydrofolate reductase activity|inhibition of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|inhibition of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|inhibition of methylenetetrahydrofolate reductase (NAD(P)H) activity|inhibition of methylenetetrahydrofolate reductase (NADPH(2)) activity|inhibition of methylenetetrahydrofolate reductase (NADPH2)|inhibition of methylenetetrahydrofolate reductase [NAD(P)H]|negative regulation of 5,10-CH(2)-H(4)folate reductase activity|negative regulation of 5,10-CH2-H4folate reductase activity|negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|negative regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|negative regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|negative regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|negative regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|negative regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|negative regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|negative regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|negative regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|negative regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|negative regulation of MetF|negative regulation of N5,10-methylenetetrahydrofolate reductase activity|negative regulation of N5,N10-methylenetetrahydrofolate reductase activity|negative regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|negative regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|negative regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|negative regulation of methylenetetrahydrofolate reductase (NADPH2)|negative regulation of methylenetetrahydrofolate reductase [NAD(P)H] http://purl.obolibrary.org/obo/GO_1903869 gocheck_do_not_annotate GO:1903868 biolink:BiologicalProcess regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity Any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity. go.json regulation of 5,10-CH(2)-H(4)folate reductase activity|regulation of 5,10-CH2-H4folate reductase activity|regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|regulation of 5,10-methylenetetrahydrofolate reductase activity|regulation of 5,10-methylenetetrahydrofolic acid reductase activity|regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|regulation of MTHFR activity|regulation of MetF|regulation of N(5),N(10)-methylenetetrahydrofolate reductase activity|regulation of N(5,10)-methylenetetrahydrofolate reductase activity|regulation of N5,10-methylenetetrahydrofolate reductase activity|regulation of N5,N10-methylenetetrahydrofolate reductase activity|regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|regulation of methylenetetrahydrofolate reductase (NADPH2)|regulation of methylenetetrahydrofolate reductase [NAD(P)H]|regulation of methylenetetrahydrofolate reductase activity|regulation of methylenetetrahydrofolic acid reductase activity http://purl.obolibrary.org/obo/GO_1903868 gocheck_do_not_annotate GO:1903867 biolink:BiologicalProcess extraembryonic membrane development The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_1903867 GO:1903866 biolink:BiologicalProcess palisade mesophyll development The process whose specific outcome is the progression of a palisade mesophyll over time, from its formation to the mature structure. go.json palisade parenchyma development http://purl.obolibrary.org/obo/GO_1903866 GO:1903865 biolink:CellularComponent sigma factor antagonist complex A protein complex which is capable of sigma factor antagonist activity. go.json http://purl.obolibrary.org/obo/GO_1903865 GO:1903864 biolink:BiologicalProcess P granule disassembly The disaggregation of a P granule into its constituent components. go.json germline granule disassembly|polar granule disassembly http://purl.obolibrary.org/obo/GO_1903864 GO:1903863 biolink:BiologicalProcess P granule assembly The aggregation, arrangement and bonding together of a set of components to form a P granule. go.json P granule formation|germline granule assembly|germline granule formation|polar granule assembly|polar granule formation http://purl.obolibrary.org/obo/GO_1903863 GO:1903862 biolink:BiologicalProcess positive regulation of oxidative phosphorylation Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation. go.json activation of oxidative phosphorylation|activation of respiratory-chain phosphorylation|positive regulation of respiratory-chain phosphorylation|up regulation of oxidative phosphorylation|up regulation of respiratory-chain phosphorylation|up-regulation of oxidative phosphorylation|up-regulation of respiratory-chain phosphorylation|upregulation of oxidative phosphorylation|upregulation of respiratory-chain phosphorylation http://purl.obolibrary.org/obo/GO_1903862 GO:1903861 biolink:BiologicalProcess positive regulation of dendrite extension Any process that activates or increases the frequency, rate or extent of dendrite extension. go.json activation of dendrite extension|up regulation of dendrite extension|up-regulation of dendrite extension|upregulation of dendrite extension http://purl.obolibrary.org/obo/GO_1903861 GO:1903860 biolink:BiologicalProcess negative regulation of dendrite extension Any process that stops, prevents or reduces the frequency, rate or extent of dendrite extension. go.json down regulation of dendrite extension|down-regulation of dendrite extension|downregulation of dendrite extension|inhibition of dendrite extension|up regulation of dendrite retraction|up-regulation of dendrite retraction http://purl.obolibrary.org/obo/GO_1903860 GO:0009099 biolink:BiologicalProcess valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. MetaCyc:VALSYN-PWY go.json valine anabolism|valine biosynthesis|valine formation|valine synthesis http://purl.obolibrary.org/obo/GO_0009099 GO:1903870 biolink:BiologicalProcess positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity Any process that activates or increases the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity. go.json activation of 5,10-CH(2)-H(4)folate reductase activity|activation of 5,10-CH2-H4folate reductase activity|activation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|activation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|activation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|activation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|activation of 5,10-methylenetetrahydropteroylglutamate reductase activity|activation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|activation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|activation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|activation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|activation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|activation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|activation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|activation of MetF|activation of N5,10-methylenetetrahydrofolate reductase activity|activation of N5,N10-methylenetetrahydrofolate reductase activity|activation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|activation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|activation of methylenetetrahydrofolate reductase (NAD(P)H) activity|activation of methylenetetrahydrofolate reductase (NADPH(2)) activity|activation of methylenetetrahydrofolate reductase (NADPH2)|activation of methylenetetrahydrofolate reductase [NAD(P)H]|positive regulation of 5,10-CH(2)-H(4)folate reductase activity|positive regulation of 5,10-CH2-H4folate reductase activity|positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|positive regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|positive regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|positive regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|positive regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|positive regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|positive regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|positive regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|positive regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|positive regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|positive regulation of MetF|positive regulation of N5,10-methylenetetrahydrofolate reductase activity|positive regulation of N5,N10-methylenetetrahydrofolate reductase activity|positive regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|positive regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|positive regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|positive regulation of methylenetetrahydrofolate reductase (NADPH2)|positive regulation of methylenetetrahydrofolate reductase [NAD(P)H]|up regulation of 5,10-CH(2)-H(4)folate reductase activity|up regulation of 5,10-CH2-H4folate reductase activity|up regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|up regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|up regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|up regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|up regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|up regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|up regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|up regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|up regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|up regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|up regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|up regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|up regulation of MetF|up regulation of N5,10-methylenetetrahydrofolate reductase activity|up regulation of N5,N10-methylenetetrahydrofolate reductase activity|up regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|up regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|up regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity|up regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|up regulation of methylenetetrahydrofolate reductase (NADPH2)|up regulation of methylenetetrahydrofolate reductase [NAD(P)H]|up-regulation of 5,10-CH(2)-H(4)folate reductase activity|up-regulation of 5,10-CH2-H4folate reductase activity|up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|up-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|up-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|up-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|up-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|up-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|up-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|up-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|up-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|up-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|up-regulation of MetF|up-regulation of N5,10-methylenetetrahydrofolate reductase activity|up-regulation of N5,N10-methylenetetrahydrofolate reductase activity|up-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|up-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|up-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity|up-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|up-regulation of methylenetetrahydrofolate reductase (NADPH2)|up-regulation of methylenetetrahydrofolate reductase [NAD(P)H]|upregulation of 5,10-CH(2)-H(4)folate reductase activity|upregulation of 5,10-CH2-H4folate reductase activity|upregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|upregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity|upregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity|upregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity|upregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity|upregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|upregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity|upregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|upregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|upregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity|upregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|upregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity|upregulation of MetF|upregulation of N5,10-methylenetetrahydrofolate reductase activity|upregulation of N5,N10-methylenetetrahydrofolate reductase activity|upregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|upregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|upregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity|upregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity|upregulation of methylenetetrahydrofolate reductase (NADPH2)|upregulation of methylenetetrahydrofolate reductase [NAD(P)H] http://purl.obolibrary.org/obo/GO_1903870 gocheck_do_not_annotate GO:0010087 biolink:BiologicalProcess phloem or xylem histogenesis The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana. go.json vascular tissue development|vascular tissue histogenesis http://purl.obolibrary.org/obo/GO_0010087 GO:0034054 biolink:BiologicalProcess symbiont-mediated suppression of host defense-related programmed cell death Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host defense-related programmed cell death|down-regulation by symbiont of host defense-related programmed cell death|downregulation by symbiont of host defense-related programmed cell death|inhibition by symbiont of host defense-related PCD|inhibition by symbiont of host defense-related programmed cell death|inhibition of HR|inhibition of host defense-related PCD|inhibition of hypersensitive response|negative regulation by symbiont of host defense-related PCD|negative regulation by symbiont of host defense-related programmed cell death|negative regulation by symbiont of plant HR|negative regulation by symbiont of plant hypersensitive response|suppression by symbiont of host defense-related programmed cell death|suppression of HR http://purl.obolibrary.org/obo/GO_0034054 GO:0034053 biolink:BiologicalProcess symbiont-mediated perturbation of host defense-related programmed cell death Any process in which a symbiont modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host HR|modulation by symbiont of host defense-related PCD|modulation by symbiont of host defense-related programmed cell death|modulation by symbiont of host hypersensitive response|modulation by symbiont of plant HR|modulation by symbiont of plant hypersensitive response http://purl.obolibrary.org/obo/GO_0034053 GO:0010086 biolink:BiologicalProcess embryonic root morphogenesis The process in which the anatomical structures of the embryonic root are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0010086 GO:0010089 biolink:BiologicalProcess xylem development The formation of the principal water-conducting tissue of a vascular plant. go.json xylem histogenesis http://purl.obolibrary.org/obo/GO_0010089 GO:0034052 biolink:BiologicalProcess positive regulation of plant-type hypersensitive response Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant. go.json activation of plant-type hypersensitive response|positive regulation of HR|positive regulation of HR-PCD|positive regulation of plant hypersensitive response|stimulation of plant-type hypersensitive response|up regulation of plant-type hypersensitive response|up-regulation of plant-type hypersensitive response|upregulation of plant-type hypersensitive response http://purl.obolibrary.org/obo/GO_0034052 GO:0010088 biolink:BiologicalProcess phloem development The formation of the principal food-conducting tissue of a vascular plant. go.json phloem histogenesis http://purl.obolibrary.org/obo/GO_0010088 GO:0034051 biolink:BiologicalProcess negative regulation of plant-type hypersensitive response Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant. go.json down regulation of plant-type hypersensitive response|down-regulation of plant-type hypersensitive response|downregulation of plant-type hypersensitive response|inhibition of plant-type hypersensitive response|negative regulation of HR|negative regulation of HR-PCD|negative regulation of plant hypersensitive response http://purl.obolibrary.org/obo/GO_0034051 GO:0034050 biolink:BiologicalProcess programmed cell death induced by symbiont Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules. go.json 'host programmed cell death induced by symbiont' http://purl.obolibrary.org/obo/GO_0034050 GO:0097637 biolink:CellularComponent obsolete integral component of autophagosome membrane OBSOLETE. The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json autophagic vacuole integral membrane protein|integral component of autophagic vacuole membrane|integral to autophagic vacuole membrane True http://purl.obolibrary.org/obo/GO_0097637 GO:0097636 biolink:CellularComponent obsolete intrinsic component of autophagosome membrane OBSOLETE. The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic component of autophagic vacuole membrane|intrinsic to autophagic vacuole membrane True http://purl.obolibrary.org/obo/GO_0097636 GO:0097639 biolink:BiologicalProcess L-lysine import across plasma membrane The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-lysine import into cell http://purl.obolibrary.org/obo/GO_0097639 GO:0010081 biolink:BiologicalProcess regulation of inflorescence meristem growth Any process involved in maintaining the size and shape of an inflorescence meristem. go.json regulation of inflorescence meristem size http://purl.obolibrary.org/obo/GO_0010081 GO:0010080 biolink:BiologicalProcess regulation of floral meristem growth Any process involved in maintaining the size and shape of a floral meristem. go.json regulation of floral meristem size http://purl.obolibrary.org/obo/GO_0010080 GO:0097638 biolink:BiologicalProcess L-arginine import across plasma membrane The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-arginine import into cell|arginine import http://purl.obolibrary.org/obo/GO_0097638 GO:0034059 biolink:BiologicalProcess response to anoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. go.json response to anoxic stress http://purl.obolibrary.org/obo/GO_0034059 GO:0097633 biolink:CellularComponent obsolete intrinsic component of phagophore assembly site membrane OBSOLETE. The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json intrinsic to phagophore assembly site membrane True http://purl.obolibrary.org/obo/GO_0097633 GO:0034058 biolink:BiologicalProcess endosomal vesicle fusion The homotypic fusion of endocytic vesicles to form or add to an early endosome. go.json endosome vesicle fusion http://purl.obolibrary.org/obo/GO_0034058 GO:0010083 biolink:BiologicalProcess regulation of vegetative meristem growth Any process involved in maintaining the size and shape of a vegetative meristem. go.json regulation of vegetative meristem size http://purl.obolibrary.org/obo/GO_0010083 GO:0097632 biolink:CellularComponent extrinsic component of phagophore assembly site membrane The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic component of pre-autophagosomal structure membrane|extrinsic to phagophore assembly site membrane|phagophore assembly site peripheral membrane http://purl.obolibrary.org/obo/GO_0097632 GO:0010082 biolink:BiologicalProcess regulation of root meristem growth Any process involved in maintaining the size and shape of a root meristem. go.json regulation of root meristem size http://purl.obolibrary.org/obo/GO_0010082 GO:0034057 biolink:MolecularActivity RNA strand-exchange activity Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. go.json http://purl.obolibrary.org/obo/GO_0034057 GO:0097635 biolink:CellularComponent obsolete extrinsic component of autophagosome membrane OBSOLETE. The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json autophagic vacuole peripheral membrane|extrinsic component of autophagic vacuole membrane|extrinsic to autophagic vacuole membrane True http://purl.obolibrary.org/obo/GO_0097635 GO:0034056 biolink:MolecularActivity estrogen response element binding Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. go.json ERE binding http://purl.obolibrary.org/obo/GO_0034056 GO:0010085 biolink:BiologicalProcess polarity specification of proximal/distal axis Any process resulting in the establishment of polarity along the proximal/distal axis. go.json http://purl.obolibrary.org/obo/GO_0010085 GO:0010084 biolink:BiologicalProcess specification of animal organ axis polarity The process in which the polarity of an animal organ axis is specified. go.json http://purl.obolibrary.org/obo/GO_0010084 GO:0034055 biolink:BiologicalProcess effector-mediated activation of programmed cell death in host A symbiont process in which a molecule secreted by the symbiont activates a programmed cell death pathway in the host to suppress the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host defense-related programmed cell death|effector-mediated induction of programmed cell death in host|enhancement by symbiont of host defense-related programmed cell death|positive regulation by symbiont of host defense-related PCD|positive regulation by symbiont of host defense-related programmed cell death|stimulation by symbiont of host defense-related programmed cell death|up regulation by symbiont of host defense-related programmed cell death|up-regulation by symbiont of host defense-related programmed cell death|upregulation by symbiont of host defense-related programmed cell death http://purl.obolibrary.org/obo/GO_0034055 GO:0097634 biolink:CellularComponent obsolete integral component of phagophore assembly site membrane OBSOLETE. The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to phagophore assembly site membrane|phagophore assembly site integral membrane protein True http://purl.obolibrary.org/obo/GO_0097634 GO:0097640 biolink:BiologicalProcess L-ornithine import across plasma membrane The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-ornithine import into cell http://purl.obolibrary.org/obo/GO_0097640 GO:0097642 biolink:MolecularActivity calcitonin family receptor activity Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0097642 GO:0097641 biolink:MolecularActivity alpha-ketoglutarate-dependent xanthine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate. RHEA:43120 go.json 2-oxoglutarate-dependent xanthine dioxygenase activity|alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity|alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity http://purl.obolibrary.org/obo/GO_0097641 GO:1903879 biolink:MolecularActivity 11beta-hydroxyprogesterone binding Binding to 11beta-hydroxyprogesterone. go.json http://purl.obolibrary.org/obo/GO_1903879 GO:1903878 biolink:MolecularActivity 11-deoxycorticosterone binding Binding to 11-deoxycorticosterone. go.json http://purl.obolibrary.org/obo/GO_1903878 GO:1903877 biolink:MolecularActivity 21-deoxycortisol binding Binding to 21-deoxycortisol. go.json http://purl.obolibrary.org/obo/GO_1903877 GO:1903876 biolink:MolecularActivity 11-deoxycortisol binding Binding to 11-deoxycortisol. go.json http://purl.obolibrary.org/obo/GO_1903876 GO:1903875 biolink:MolecularActivity corticosterone binding Binding to corticosterone. go.json http://purl.obolibrary.org/obo/GO_1903875 GO:1903874 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903874 GO:1903873 biolink:BiologicalProcess negative regulation of DNA recombinase mediator complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombinase mediator complex assembly. go.json down regulation of DNA recombinase mediator complex assembly|down regulation of DNA recombinase mediator complex formation|down-regulation of DNA recombinase mediator complex assembly|down-regulation of DNA recombinase mediator complex formation|downregulation of DNA recombinase mediator complex assembly|downregulation of DNA recombinase mediator complex formation|inhibition of DNA recombinase mediator complex assembly|inhibition of DNA recombinase mediator complex formation|negative regulation of DNA recombinase mediator complex formation http://purl.obolibrary.org/obo/GO_1903873 GO:1903872 biolink:BiologicalProcess regulation of DNA recombinase mediator complex assembly Any process that modulates the frequency, rate or extent of DNA recombinase mediator complex assembly. go.json regulation of DNA recombinase mediator complex formation http://purl.obolibrary.org/obo/GO_1903872 GO:1903871 biolink:BiologicalProcess DNA recombinase mediator complex assembly The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex. go.json DNA recombinase mediator complex formation http://purl.obolibrary.org/obo/GO_1903871 GO:0034043 biolink:MolecularActivity 5-hydroxymethyluracil DNA N-glycosylase activity Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. go.json 5-hmU DNA N-glycosylase activity http://purl.obolibrary.org/obo/GO_0034043 GO:0010098 biolink:BiologicalProcess suspensor development The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm. go.json http://purl.obolibrary.org/obo/GO_0010098 GO:1903881 biolink:BiologicalProcess regulation of interleukin-17-mediated signaling pathway Any process that modulates the frequency, rate or extent of interleukin-17-mediated signaling pathway. go.json regulation of IL-17-mediated signaling pathway|regulation of IL-17-mediated signalling pathway|regulation of interleukin-17-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1903881 GO:0034042 biolink:MolecularActivity 5-formyluracil DNA N-glycosylase activity Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. go.json 5-foU DNA N-glycosylase activity http://purl.obolibrary.org/obo/GO_0034042 GO:1903880 biolink:MolecularActivity 17alpha-hydroxyprogesterone binding Binding to 17alpha-hydroxyprogesterone. go.json http://purl.obolibrary.org/obo/GO_1903880 GO:0010097 biolink:BiologicalProcess specification of stamen identity The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010097 GO:0034041 biolink:MolecularActivity ABC-type sterol transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out). go.json ATP-coupled sterol transmembrane transporter activity|ATP-dependent sterol transmembrane transporter activity|ATPase-coupled sterol transmembrane transporter activity|sterol-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0034041 GO:0034040 biolink:MolecularActivity ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). go.json ATP-dependent lipid transmembrane transporter activity|lipid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0034040 GO:0010099 biolink:BiologicalProcess regulation of photomorphogenesis Any process that modulates the rate or extent of photomorphogenesis. go.json http://purl.obolibrary.org/obo/GO_0010099 GO:0010090 biolink:BiologicalProcess trichome morphogenesis The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana. go.json trichome cell morphogenesis during differentiation http://purl.obolibrary.org/obo/GO_0010090 GO:0097648 biolink:CellularComponent G protein-coupled receptor complex A protein complex that contains G protein-coupled receptors. go.json G-protein coupled receptor complex http://purl.obolibrary.org/obo/GO_0097648 GO:0097647 biolink:BiologicalProcess amylin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json amilyn receptor signalling pathway http://purl.obolibrary.org/obo/GO_0097647 GO:0010092 biolink:BiologicalProcess specification of animal organ identity The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010092 GO:0034049 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034049 GO:0097649 biolink:CellularComponent A axonemal microtubule A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule. go.json A tubule http://purl.obolibrary.org/obo/GO_0097649 GO:0010091 biolink:BiologicalProcess trichome branching Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0010091 GO:0034048 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034048 GO:0034047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034047 GO:0097644 biolink:MolecularActivity calcitonin family binding Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)). go.json http://purl.obolibrary.org/obo/GO_0097644 GO:0010094 biolink:BiologicalProcess specification of carpel identity The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010094 GO:0097643 biolink:MolecularActivity amylin receptor activity Combining with amylin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0097643 GO:0010093 biolink:BiologicalProcess specification of floral organ identity The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010093 GO:0034046 biolink:MolecularActivity poly(G) binding Binding to a sequence of guanine residues in an RNA molecule. go.json poly(G) binding, within an RNA molecule|poly(rG) binding http://purl.obolibrary.org/obo/GO_0034046 GO:0097646 biolink:BiologicalProcess calcitonin family receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json calcitonin family receptor signalling pathway http://purl.obolibrary.org/obo/GO_0097646 GO:0034045 biolink:CellularComponent phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site. go.json PAS membrane|isolation membrane|phagophore|pre-autophagosomal structure membrane http://purl.obolibrary.org/obo/GO_0034045 GO:0010096 biolink:BiologicalProcess specification of sepal identity The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010096 GO:0034044 biolink:CellularComponent exomer complex A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues. go.json http://purl.obolibrary.org/obo/GO_0034044 GO:0097645 biolink:MolecularActivity amylin binding Binding to amylin. go.json http://purl.obolibrary.org/obo/GO_0097645 GO:0010095 biolink:BiologicalProcess specification of petal identity The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0010095 GO:1903889 biolink:BiologicalProcess negative regulation of plant epidermal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of plant epidermal cell differentiation. go.json down regulation of plant epidermal cell differentiation|down-regulation of plant epidermal cell differentiation|downregulation of plant epidermal cell differentiation|inhibition of plant epidermal cell differentiation http://purl.obolibrary.org/obo/GO_1903889 GO:1903888 biolink:BiologicalProcess regulation of plant epidermal cell differentiation Any process that modulates the frequency, rate or extent of plant epidermal cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1903888 GO:1903887 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903887 GO:1903886 biolink:BiologicalProcess positive regulation of chemokine (C-C motif) ligand 20 production Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. go.json activation of C-C motif chemokine 20 production|activation of CCL-20 production|activation of CCL20 production|activation of chemokine (C-C motif) ligand 20 production|positive regulation of C-C motif chemokine 20 production|positive regulation of CCL-20 production|positive regulation of CCL20 production|up regulation of C-C motif chemokine 20 production|up regulation of CCL-20 production|up regulation of CCL20 production|up regulation of chemokine (C-C motif) ligand 20 production|up-regulation of C-C motif chemokine 20 production|up-regulation of CCL-20 production|up-regulation of CCL20 production|up-regulation of chemokine (C-C motif) ligand 20 production|upregulation of C-C motif chemokine 20 production|upregulation of CCL-20 production|upregulation of CCL20 production|upregulation of chemokine (C-C motif) ligand 20 production http://purl.obolibrary.org/obo/GO_1903886 GO:1903885 biolink:BiologicalProcess negative regulation of chemokine (C-C motif) ligand 20 production Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. go.json down regulation of C-C motif chemokine 20 production|down regulation of CCL-20 production|down regulation of CCL20 production|down regulation of chemokine (C-C motif) ligand 20 production|down-regulation of C-C motif chemokine 20 production|down-regulation of CCL-20 production|down-regulation of CCL20 production|down-regulation of chemokine (C-C motif) ligand 20 production|downregulation of C-C motif chemokine 20 production|downregulation of CCL-20 production|downregulation of CCL20 production|downregulation of chemokine (C-C motif) ligand 20 production|inhibition of C-C motif chemokine 20 production|inhibition of CCL-20 production|inhibition of CCL20 production|inhibition of chemokine (C-C motif) ligand 20 production|negative regulation of C-C motif chemokine 20 production|negative regulation of CCL-20 production|negative regulation of CCL20 production http://purl.obolibrary.org/obo/GO_1903885 GO:1903884 biolink:BiologicalProcess regulation of chemokine (C-C motif) ligand 20 production Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. go.json regulation of C-C motif chemokine 20 production|regulation of CCL-20 production|regulation of CCL20 production http://purl.obolibrary.org/obo/GO_1903884 GO:0009079 biolink:BiologicalProcess pyruvate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine. go.json pyruvate family amino acid anabolism|pyruvate family amino acid biosynthesis|pyruvate family amino acid formation|pyruvate family amino acid synthesis http://purl.obolibrary.org/obo/GO_0009079 GO:0009078 biolink:BiologicalProcess pyruvate family amino acid metabolic process The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine. go.json pyruvate family amino acid metabolism http://purl.obolibrary.org/obo/GO_0009078 GO:1903883 biolink:BiologicalProcess positive regulation of interleukin-17-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway. go.json activation of IL-17-mediated signaling pathway|activation of IL-17-mediated signalling pathway|activation of interleukin-17-mediated signaling pathway|activation of interleukin-17-mediated signalling pathway|positive regulation of IL-17-mediated signaling pathway|positive regulation of IL-17-mediated signalling pathway|positive regulation of interleukin-17-mediated signalling pathway|up regulation of IL-17-mediated signaling pathway|up regulation of IL-17-mediated signalling pathway|up regulation of interleukin-17-mediated signaling pathway|up regulation of interleukin-17-mediated signalling pathway|up-regulation of IL-17-mediated signaling pathway|up-regulation of IL-17-mediated signalling pathway|up-regulation of interleukin-17-mediated signaling pathway|up-regulation of interleukin-17-mediated signalling pathway|upregulation of IL-17-mediated signaling pathway|upregulation of IL-17-mediated signalling pathway|upregulation of interleukin-17-mediated signaling pathway|upregulation of interleukin-17-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1903883 GO:1903882 biolink:BiologicalProcess negative regulation of interleukin-17-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17-mediated signaling pathway. go.json down regulation of IL-17-mediated signaling pathway|down regulation of IL-17-mediated signalling pathway|down regulation of interleukin-17-mediated signaling pathway|down regulation of interleukin-17-mediated signalling pathway|down-regulation of IL-17-mediated signaling pathway|down-regulation of IL-17-mediated signalling pathway|down-regulation of interleukin-17-mediated signaling pathway|down-regulation of interleukin-17-mediated signalling pathway|downregulation of IL-17-mediated signaling pathway|downregulation of IL-17-mediated signalling pathway|downregulation of interleukin-17-mediated signaling pathway|downregulation of interleukin-17-mediated signalling pathway|inhibition of IL-17-mediated signaling pathway|inhibition of IL-17-mediated signalling pathway|inhibition of interleukin-17-mediated signaling pathway|inhibition of interleukin-17-mediated signalling pathway|negative regulation of IL-17-mediated signaling pathway|negative regulation of IL-17-mediated signalling pathway|negative regulation of interleukin-17-mediated signalling pathway http://purl.obolibrary.org/obo/GO_1903882 GO:0009077 biolink:BiologicalProcess obsolete histidine family amino acid catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family. go.json histidine family amino acid breakdown|histidine family amino acid catabolic process|histidine family amino acid catabolism|histidine family amino acid degradation True http://purl.obolibrary.org/obo/GO_0009077 GO:1903892 biolink:BiologicalProcess negative regulation of ATF6-mediated unfolded protein response Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response. go.json down regulation of ATF6 branch of UPR|down regulation of ATF6 signaling in response to endoplasmic reticulum stress|down regulation of ATF6-alpha UPR branch|down regulation of ATF6-beta UPR branch|down regulation of ATF6-mediated unfolded protein response|down regulation of UPR signaling by ATF6 stress sensor|down regulation of activating transcription factor 6 signaling in unfolded protein response|down regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling|down-regulation of ATF6 branch of UPR|down-regulation of ATF6 signaling in response to endoplasmic reticulum stress|down-regulation of ATF6-alpha UPR branch|down-regulation of ATF6-beta UPR branch|down-regulation of ATF6-mediated unfolded protein response|down-regulation of UPR signaling by ATF6 stress sensor|down-regulation of activating transcription factor 6 signaling in unfolded protein response|down-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling|downregulation of ATF6 branch of UPR|downregulation of ATF6 signaling in response to endoplasmic reticulum stress|downregulation of ATF6-alpha UPR branch|downregulation of ATF6-beta UPR branch|downregulation of ATF6-mediated unfolded protein response|downregulation of UPR signaling by ATF6 stress sensor|downregulation of activating transcription factor 6 signaling in unfolded protein response|downregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling|inhibition of ATF6 branch of UPR|inhibition of ATF6 signaling in response to endoplasmic reticulum stress|inhibition of ATF6-alpha UPR branch|inhibition of ATF6-beta UPR branch|inhibition of ATF6-mediated unfolded protein response|inhibition of UPR signaling by ATF6 stress sensor|inhibition of activating transcription factor 6 signaling in unfolded protein response|inhibition of endoplasmic reticulum unfolded protein response; ATF6 signaling|negative regulation of ATF6 branch of UPR|negative regulation of ATF6 signaling in response to endoplasmic reticulum stress|negative regulation of ATF6-alpha UPR branch|negative regulation of ATF6-beta UPR branch|negative regulation of UPR signaling by ATF6 stress sensor|negative regulation of activating transcription factor 6 signaling in unfolded protein response|negative regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling http://purl.obolibrary.org/obo/GO_1903892 GO:0009087 biolink:BiologicalProcess methionine catabolic process The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. UM-BBD_pathwayID:met go.json methionine breakdown|methionine catabolism|methionine degradation http://purl.obolibrary.org/obo/GO_0009087 GO:0010065 biolink:BiologicalProcess primary meristem tissue development The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium. go.json primary meristem histogenesis http://purl.obolibrary.org/obo/GO_0010065 GO:0034032 biolink:BiologicalProcess purine nucleoside bisphosphate metabolic process The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json purine nucleoside bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0034032 GO:1903891 biolink:BiologicalProcess regulation of ATF6-mediated unfolded protein response Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response. go.json regulation of ATF6 branch of UPR|regulation of ATF6 signal transduction pathway|regulation of ATF6 signaling in response to endoplasmic reticulum stress|regulation of ATF6-alpha UPR branch|regulation of ATF6-beta UPR branch|regulation of UPR signaling by ATF6 stress sensor|regulation of activating transcription factor 6 signaling in unfolded protein response|regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling http://purl.obolibrary.org/obo/GO_1903891 GO:0009086 biolink:BiologicalProcess methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. go.json methionine anabolism|methionine biosynthesis|methionine formation|methionine synthesis http://purl.obolibrary.org/obo/GO_0009086 GO:0034031 biolink:BiologicalProcess ribonucleoside bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json ribonucleoside bisphosphate breakdown|ribonucleoside bisphosphate catabolism|ribonucleoside bisphosphate degradation http://purl.obolibrary.org/obo/GO_0034031 GO:0010064 biolink:BiologicalProcess embryonic shoot morphogenesis The process in which the anatomical structures of embryonic shoot are generated and organized. go.json primary shoot system morphogenesis http://purl.obolibrary.org/obo/GO_0010064 GO:1903890 biolink:BiologicalProcess positive regulation of plant epidermal cell differentiation Any process that activates or increases the frequency, rate or extent of plant epidermal cell differentiation. go.json activation of plant epidermal cell differentiation|up regulation of plant epidermal cell differentiation|up-regulation of plant epidermal cell differentiation|upregulation of plant epidermal cell differentiation http://purl.obolibrary.org/obo/GO_1903890 GO:0034030 biolink:BiologicalProcess ribonucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json ribonucleoside bisphosphate anabolism|ribonucleoside bisphosphate biosynthesis|ribonucleoside bisphosphate formation|ribonucleoside bisphosphate synthesis http://purl.obolibrary.org/obo/GO_0034030 GO:0009085 biolink:BiologicalProcess lysine biosynthetic process The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. MetaCyc:PWY-5097 go.json lysine anabolism|lysine biosynthesis|lysine formation|lysine synthesis http://purl.obolibrary.org/obo/GO_0009085 GO:0010067 biolink:BiologicalProcess procambium histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue. go.json http://purl.obolibrary.org/obo/GO_0010067 GO:0009084 biolink:BiologicalProcess glutamine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. go.json glutamine family amino acid anabolism|glutamine family amino acid biosynthesis|glutamine family amino acid formation|glutamine family amino acid synthesis http://purl.obolibrary.org/obo/GO_0009084 GO:0010066 biolink:BiologicalProcess ground meristem histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues. go.json http://purl.obolibrary.org/obo/GO_0010066 GO:0009083 biolink:BiologicalProcess branched-chain amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. go.json branched chain family amino acid breakdown|branched chain family amino acid catabolic process|branched chain family amino acid catabolism|branched chain family amino acid degradation http://purl.obolibrary.org/obo/GO_0009083 GO:0010069 biolink:BiologicalProcess zygote asymmetric cytokinesis in embryo sac The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana. go.json http://purl.obolibrary.org/obo/GO_0010069 GO:0097619 biolink:CellularComponent PTEX complex A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components. go.json Plasmodium translocon of exported proteins http://purl.obolibrary.org/obo/GO_0097619 GO:0009082 biolink:BiologicalProcess branched-chain amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. go.json branched chain family amino acid anabolism|branched chain family amino acid biosynthesis|branched chain family amino acid biosynthetic process|branched chain family amino acid formation|branched chain family amino acid synthesis http://purl.obolibrary.org/obo/GO_0009082 GO:0097618 biolink:CellularComponent dinoflagellate sulcal notch A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed. go.json dinoflagellate sulcus notch|sulcal notch http://purl.obolibrary.org/obo/GO_0097618 GO:0010068 biolink:BiologicalProcess protoderm histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the epidermis. go.json http://purl.obolibrary.org/obo/GO_0010068 GO:0009081 biolink:BiologicalProcess branched-chain amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. go.json branched chain family amino acid metabolism http://purl.obolibrary.org/obo/GO_0009081 GO:0009080 biolink:BiologicalProcess pyruvate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine. go.json pyruvate family amino acid breakdown|pyruvate family amino acid catabolism|pyruvate family amino acid degradation http://purl.obolibrary.org/obo/GO_0009080 GO:0097615 biolink:BiologicalProcess modulation by host of symbiont type IV pilus-dependent motility The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by host of bacterial type IV pilus-dependent motility http://purl.obolibrary.org/obo/GO_0097615 GO:0097614 biolink:CellularComponent dinoflagellate hypocone The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum. go.json hypocone|hyposome|hypotheca http://purl.obolibrary.org/obo/GO_0097614 GO:0034039 biolink:MolecularActivity 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. go.json 8-oxoG DNA N-glycosylase activity http://purl.obolibrary.org/obo/GO_0034039 GO:0034038 biolink:MolecularActivity deoxyhypusine synthase activity Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. EC:2.5.1.46|MetaCyc:2.5.1.46-RXN|RHEA:33299|Reactome:R-HSA-204617|Reactome:R-HSA-204647 go.json (4-aminobutyl)lysine synthase|eIF-5A-deoxyhypusine synthase activity|spermidine dehydrogenase http://purl.obolibrary.org/obo/GO_0034038 GO:0097617 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097617 GO:0097616 biolink:BiologicalProcess positive regulation by host of symbiont type IV pilus-dependent motility Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by host of bacterial type IV pilus-dependent motility http://purl.obolibrary.org/obo/GO_0097616 GO:0034037 biolink:BiologicalProcess purine ribonucleoside bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json purine ribonucleoside bisphosphate breakdown|purine ribonucleoside bisphosphate catabolism|purine ribonucleoside bisphosphate degradation http://purl.obolibrary.org/obo/GO_0034037 GO:0010061 biolink:BiologicalProcess regulation of trichoblast fate specification Any process that modulates trichoblast fate specification. go.json http://purl.obolibrary.org/obo/GO_0010061 GO:0097611 biolink:CellularComponent dinoflagellate cingulum A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it. go.json cingulum|girdle|transverse groove http://purl.obolibrary.org/obo/GO_0097611 GO:0034036 biolink:BiologicalProcess purine ribonucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json purine ribonucleoside bisphosphate anabolism|purine ribonucleoside bisphosphate biosynthesis|purine ribonucleoside bisphosphate formation|purine ribonucleoside bisphosphate synthesis http://purl.obolibrary.org/obo/GO_0034036 GO:0097610 biolink:CellularComponent cell surface furrow A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates. go.json cell surface groove|furrow|groove http://purl.obolibrary.org/obo/GO_0097610 GO:0034035 biolink:BiologicalProcess purine ribonucleoside bisphosphate metabolic process The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json purine ribonucleoside bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0034035 GO:0010060 biolink:BiologicalProcess negative regulation of atrichoblast fate specification Any process that suppresses atrichoblast fate specification. go.json down regulation of atrichoblast fate|down-regulation of atrichoblast fate|downregulation of atrichoblast fate|inhibition of atrichoblast fate http://purl.obolibrary.org/obo/GO_0010060 GO:0034034 biolink:BiologicalProcess purine nucleoside bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json purine nucleoside bisphosphate breakdown|purine nucleoside bisphosphate catabolism|purine nucleoside bisphosphate degradation http://purl.obolibrary.org/obo/GO_0034034 GO:0010063 biolink:BiologicalProcess positive regulation of trichoblast fate specification Any process that induces or promotes trichoblast fate specification. go.json activation of trichoblast fate|stimulation of trichoblast fate|up regulation of trichoblast fate|up-regulation of trichoblast fate|upregulation of trichoblast fate http://purl.obolibrary.org/obo/GO_0010063 GO:0097613 biolink:CellularComponent dinoflagellate epicone The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum. go.json epicone|episome|epitheca http://purl.obolibrary.org/obo/GO_0097613 GO:0097612 biolink:CellularComponent dinoflagellate sulcus A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell. go.json longitudinal furrow|longitudinal groove|sulcus http://purl.obolibrary.org/obo/GO_0097612 GO:0010062 biolink:BiologicalProcess negative regulation of trichoblast fate specification Any process that suppresses trichoblast fate specification. go.json down regulation of trichoblast fate|down-regulation of trichoblast fate|downregulation of trichoblast fate|inhibition of trichoblast fate http://purl.obolibrary.org/obo/GO_0010062 GO:0034033 biolink:BiologicalProcess purine nucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json purine nucleoside bisphosphate anabolism|purine nucleoside bisphosphate biosynthesis|purine nucleoside bisphosphate formation|purine nucleoside bisphosphate synthesis http://purl.obolibrary.org/obo/GO_0034033 GO:0097620 biolink:MolecularActivity (R)-mandelate dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor. RHEA:43112 go.json D-mandelate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0097620 GO:1903899 biolink:BiologicalProcess positive regulation of PERK-mediated unfolded protein response Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response. go.json activation of PERK branch of UPR|activation of PERK signaling in response to endoplasmic reticulum stress|activation of PERK-mediated unfolded protein response|activation of PKR-like ER kinase signal transduction|activation of UPR signaling by PERK stress sensor|activation of endoplasmic reticulum unfolded protein response; PERK signaling|positive regulation of EIF2AK3-mediated unfolded protein response|positive regulation of PERK branch of UPR|positive regulation of PERK signaling in response to endoplasmic reticulum stress|positive regulation of PKR-like ER kinase signal transduction|positive regulation of UPR signaling by PERK stress sensor|positive regulation of endoplasmic reticulum unfolded protein response; PERK signaling|up regulation of PERK branch of UPR|up regulation of PERK signaling in response to endoplasmic reticulum stress|up regulation of PERK-mediated unfolded protein response|up regulation of PKR-like ER kinase signal transduction|up regulation of UPR signaling by PERK stress sensor|up regulation of endoplasmic reticulum unfolded protein response; PERK signaling|up-regulation of PERK branch of UPR|up-regulation of PERK signaling in response to endoplasmic reticulum stress|up-regulation of PERK-mediated unfolded protein response|up-regulation of PKR-like ER kinase signal transduction|up-regulation of UPR signaling by PERK stress sensor|up-regulation of endoplasmic reticulum unfolded protein response; PERK signaling|upregulation of PERK branch of UPR|upregulation of PERK signaling in response to endoplasmic reticulum stress|upregulation of PERK-mediated unfolded protein response|upregulation of PKR-like ER kinase signal transduction|upregulation of UPR signaling by PERK stress sensor|upregulation of endoplasmic reticulum unfolded protein response; PERK signaling http://purl.obolibrary.org/obo/GO_1903899 GO:1903898 biolink:BiologicalProcess negative regulation of PERK-mediated unfolded protein response Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response. go.json down regulation of PERK branch of UPR|down regulation of PERK signaling in response to endoplasmic reticulum stress|down regulation of PERK-mediated unfolded protein response|down regulation of PKR-like ER kinase signal transduction|down regulation of UPR signaling by PERK stress sensor|down regulation of endoplasmic reticulum unfolded protein response; PERK signaling|down-regulation of PERK branch of UPR|down-regulation of PERK signaling in response to endoplasmic reticulum stress|down-regulation of PERK-mediated unfolded protein response|down-regulation of PKR-like ER kinase signal transduction|down-regulation of UPR signaling by PERK stress sensor|down-regulation of endoplasmic reticulum unfolded protein response; PERK signaling|downregulation of PERK branch of UPR|downregulation of PERK signaling in response to endoplasmic reticulum stress|downregulation of PERK-mediated unfolded protein response|downregulation of PKR-like ER kinase signal transduction|downregulation of UPR signaling by PERK stress sensor|downregulation of endoplasmic reticulum unfolded protein response; PERK signaling|inhibition of PERK branch of UPR|inhibition of PERK signaling in response to endoplasmic reticulum stress|inhibition of PERK-mediated unfolded protein response|inhibition of PKR-like ER kinase signal transduction|inhibition of UPR signaling by PERK stress sensor|inhibition of endoplasmic reticulum unfolded protein response; PERK signaling|negative regulation of EIF2AK3-mediated unfolded protein response|negative regulation of PERK branch of UPR|negative regulation of PERK signaling in response to endoplasmic reticulum stress|negative regulation of PKR-like ER kinase signal transduction|negative regulation of UPR signaling by PERK stress sensor|negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling http://purl.obolibrary.org/obo/GO_1903898 GO:1903897 biolink:BiologicalProcess regulation of PERK-mediated unfolded protein response Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response. go.json regulation of EIF2AK3-mediated unfolded protein response|regulation of PERK branch of UPR|regulation of PERK signal transduction pathway|regulation of PERK signaling in response to endoplasmic reticulum stress|regulation of PKR-like ER kinase signal transduction|regulation of UPR signaling by PERK stress sensor|regulation of endoplasmic reticulum unfolded protein response; PERK signaling http://purl.obolibrary.org/obo/GO_1903897 GO:1903896 biolink:BiologicalProcess positive regulation of IRE1-mediated unfolded protein response Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response. go.json activation of IRE1 branch of UPR|activation of IRE1 signaling in response to endoplasmic reticulum stress|activation of IRE1-mediated unfolded protein response|activation of IRE1alpha unfolded protein response|activation of IRE1p unfolded protein response|activation of UPR signaling by IRE1 stress sensor|activation of endoplasmic reticulum unfolded protein response; IRE1 signaling|activation of inositol-requiring transmembrane kinase/endonuclease signal transduction|positive regulation of ERN1-mediated unfolded protein response|positive regulation of IRE1 branch of UPR|positive regulation of IRE1 signaling in response to endoplasmic reticulum stress|positive regulation of IRE1alpha unfolded protein response|positive regulation of IRE1p unfolded protein response|positive regulation of UPR signaling by IRE1 stress sensor|positive regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|positive regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction|up regulation of IRE1 branch of UPR|up regulation of IRE1 signaling in response to endoplasmic reticulum stress|up regulation of IRE1-mediated unfolded protein response|up regulation of IRE1alpha unfolded protein response|up regulation of IRE1p unfolded protein response|up regulation of UPR signaling by IRE1 stress sensor|up regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|up regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction|up-regulation of IRE1 branch of UPR|up-regulation of IRE1 signaling in response to endoplasmic reticulum stress|up-regulation of IRE1-mediated unfolded protein response|up-regulation of IRE1alpha unfolded protein response|up-regulation of IRE1p unfolded protein response|up-regulation of UPR signaling by IRE1 stress sensor|up-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|up-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction|upregulation of IRE1 branch of UPR|upregulation of IRE1 signaling in response to endoplasmic reticulum stress|upregulation of IRE1-mediated unfolded protein response|upregulation of IRE1alpha unfolded protein response|upregulation of IRE1p unfolded protein response|upregulation of UPR signaling by IRE1 stress sensor|upregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|upregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction http://purl.obolibrary.org/obo/GO_1903896 GO:1903895 biolink:BiologicalProcess negative regulation of IRE1-mediated unfolded protein response Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response. go.json down regulation of IRE1 branch of UPR|down regulation of IRE1 signaling in response to endoplasmic reticulum stress|down regulation of IRE1-mediated unfolded protein response|down regulation of IRE1alpha unfolded protein response|down regulation of IRE1p unfolded protein response|down regulation of UPR signaling by IRE1 stress sensor|down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction|down-regulation of IRE1 branch of UPR|down-regulation of IRE1 signaling in response to endoplasmic reticulum stress|down-regulation of IRE1-mediated unfolded protein response|down-regulation of IRE1alpha unfolded protein response|down-regulation of IRE1p unfolded protein response|down-regulation of UPR signaling by IRE1 stress sensor|down-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|down-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction|downregulation of IRE1 branch of UPR|downregulation of IRE1 signaling in response to endoplasmic reticulum stress|downregulation of IRE1-mediated unfolded protein response|downregulation of IRE1alpha unfolded protein response|downregulation of IRE1p unfolded protein response|downregulation of UPR signaling by IRE1 stress sensor|downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction|inhibition of IRE1 branch of UPR|inhibition of IRE1 signaling in response to endoplasmic reticulum stress|inhibition of IRE1-mediated unfolded protein response|inhibition of IRE1alpha unfolded protein response|inhibition of IRE1p unfolded protein response|inhibition of UPR signaling by IRE1 stress sensor|inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling|inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction|negative regulation of ERN1-mediated unfolded protein response|negative regulation of IRE1 branch of UPR|negative regulation of IRE1 signaling in response to endoplasmic reticulum stress|negative regulation of IRE1alpha unfolded protein response|negative regulation of IRE1p unfolded protein response|negative regulation of UPR signaling by IRE1 stress sensor|negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction http://purl.obolibrary.org/obo/GO_1903895 GO:1903894 biolink:BiologicalProcess regulation of IRE1-mediated unfolded protein response Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. go.json regulation of ERN1-mediated unfolded protein response|regulation of IRE1 branch of UPR|regulation of IRE1 signal transduction pathway|regulation of IRE1 signaling in response to endoplasmic reticulum stress|regulation of IRE1alpha unfolded protein response|regulation of IRE1p unfolded protein response|regulation of UPR signaling by IRE1 stress sensor|regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling|regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction http://purl.obolibrary.org/obo/GO_1903894 GO:0009089 biolink:BiologicalProcess lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. go.json diaminopimelate pathway|diaminopimelic acid pathway|lysine anabolism via diaminopimelate|lysine biosynthesis via diaminopimelic acid|lysine biosynthetic process via diaminopimelic acid|lysine formation via diaminopimelate|lysine synthesis via diaminopimelate http://purl.obolibrary.org/obo/GO_0009089 GO:0009088 biolink:BiologicalProcess threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. MetaCyc:HOMOSER-THRESYN-PWY|MetaCyc:THRESYN-PWY go.json threonine anabolism|threonine biosynthesis|threonine formation|threonine synthesis http://purl.obolibrary.org/obo/GO_0009088 GO:1903893 biolink:BiologicalProcess positive regulation of ATF6-mediated unfolded protein response Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response. go.json activation of ATF6 branch of UPR|activation of ATF6 signaling in response to endoplasmic reticulum stress|activation of ATF6-alpha UPR branch|activation of ATF6-beta UPR branch|activation of ATF6-mediated unfolded protein response|activation of UPR signaling by ATF6 stress sensor|activation of activating transcription factor 6 signaling in unfolded protein response|activation of endoplasmic reticulum unfolded protein response; ATF6 signaling|positive regulation of ATF6 branch of UPR|positive regulation of ATF6 signaling in response to endoplasmic reticulum stress|positive regulation of ATF6-alpha UPR branch|positive regulation of ATF6-beta UPR branch|positive regulation of UPR signaling by ATF6 stress sensor|positive regulation of activating transcription factor 6 signaling in unfolded protein response|positive regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling|up regulation of ATF6 branch of UPR|up regulation of ATF6 signaling in response to endoplasmic reticulum stress|up regulation of ATF6-alpha UPR branch|up regulation of ATF6-beta UPR branch|up regulation of ATF6-mediated unfolded protein response|up regulation of UPR signaling by ATF6 stress sensor|up regulation of activating transcription factor 6 signaling in unfolded protein response|up regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling|up-regulation of ATF6 branch of UPR|up-regulation of ATF6 signaling in response to endoplasmic reticulum stress|up-regulation of ATF6-alpha UPR branch|up-regulation of ATF6-beta UPR branch|up-regulation of ATF6-mediated unfolded protein response|up-regulation of UPR signaling by ATF6 stress sensor|up-regulation of activating transcription factor 6 signaling in unfolded protein response|up-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling|upregulation of ATF6 branch of UPR|upregulation of ATF6 signaling in response to endoplasmic reticulum stress|upregulation of ATF6-alpha UPR branch|upregulation of ATF6-beta UPR branch|upregulation of ATF6-mediated unfolded protein response|upregulation of UPR signaling by ATF6 stress sensor|upregulation of activating transcription factor 6 signaling in unfolded protein response|upregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling http://purl.obolibrary.org/obo/GO_1903893 GO:0009098 biolink:BiologicalProcess leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. MetaCyc:LEUSYN-PWY go.json leucine anabolism|leucine biosynthesis|leucine formation|leucine synthesis http://purl.obolibrary.org/obo/GO_0009098 GO:0010076 biolink:BiologicalProcess maintenance of floral meristem identity The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. go.json http://purl.obolibrary.org/obo/GO_0010076 GO:0034021 biolink:BiologicalProcess response to silicon dioxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus. go.json response to silica|response to silox http://purl.obolibrary.org/obo/GO_0034021 GO:0009097 biolink:BiologicalProcess isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. MetaCyc:ILEUSYN-PWY go.json isoleucine anabolism|isoleucine biosynthesis|isoleucine formation|isoleucine synthesis http://purl.obolibrary.org/obo/GO_0009097 GO:0010075 biolink:BiologicalProcess regulation of meristem growth Any process involved in maintaining the size and shape of a meristem. go.json regulation of meristem size http://purl.obolibrary.org/obo/GO_0010075 GO:0034020 biolink:MolecularActivity neoxanthin synthase activity Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin. EC:5.3.99.9|KEGG_REACTION:R06948|MetaCyc:RXN1F-155|RHEA:10128 go.json NSY|violaxanthin-neoxanthin isomerase (epoxide-opening) activity http://purl.obolibrary.org/obo/GO_0034020 GO:0009096 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009096 GO:0010078 biolink:BiologicalProcess maintenance of root meristem identity The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. go.json http://purl.obolibrary.org/obo/GO_0010078 GO:0009095 biolink:BiologicalProcess aromatic amino acid family biosynthetic process, prephenate pathway The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate. go.json aromatic amino acid family anabolism, prephenate pathway|aromatic amino acid family biosynthetic process via prephenate|aromatic amino acid family biosynthetic process via prephenate(2-)|aromatic amino acid family formation, prephenate pathway|aromatic amino acid family synthesis, prephenate pathway http://purl.obolibrary.org/obo/GO_0009095 GO:0010077 biolink:BiologicalProcess maintenance of inflorescence meristem identity The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. go.json http://purl.obolibrary.org/obo/GO_0010077 GO:0009094 biolink:BiologicalProcess L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. go.json L-phenylalanine anabolism|L-phenylalanine biosynthesis|L-phenylalanine formation|L-phenylalanine synthesis|phenylalanine biosynthesis|phenylalanine biosynthetic process|phenylalanine biosynthetic process, prephenate pathway|phenylalanine biosynthetic process, shikimate pathway http://purl.obolibrary.org/obo/GO_0009094 GO:0009093 biolink:BiologicalProcess cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid. Wikipedia:Cysteine go.json cysteine breakdown|cysteine catabolism|cysteine degradation http://purl.obolibrary.org/obo/GO_0009093 GO:0010079 biolink:BiologicalProcess maintenance of vegetative meristem identity The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. go.json http://purl.obolibrary.org/obo/GO_0010079 GO:0097629 biolink:CellularComponent extrinsic component of omegasome membrane The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to omegasome membrane|omegasome peripheral membrane http://purl.obolibrary.org/obo/GO_0097629 GO:0009092 biolink:BiologicalProcess homoserine metabolic process The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. go.json homoserine metabolism http://purl.obolibrary.org/obo/GO_0009092 GO:0009091 biolink:BiologicalProcess homoserine catabolic process The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid. MetaCyc:HOMOCYSDEGR-PWY go.json homoserine breakdown|homoserine catabolism|homoserine degradation http://purl.obolibrary.org/obo/GO_0009091 GO:0009090 biolink:BiologicalProcess homoserine biosynthetic process The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid. MetaCyc:HOMOSERSYN-PWY go.json homoserine anabolism|homoserine biosynthesis|homoserine formation|homoserine synthesis http://purl.obolibrary.org/obo/GO_0009090 GO:0034029 biolink:MolecularActivity 2-oxoglutarate carboxylase activity Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H+ + oxalosuccinate + phosphate. EC:6.4.1.7|KEGG_REACTION:R08201|MetaCyc:RXN-8457|RHEA:20425 go.json CFI|OGC|carboxylating factor for ICDH|oxalosuccinate synthetase activity http://purl.obolibrary.org/obo/GO_0034029 GO:0097626 biolink:MolecularActivity low-affinity L-arginine transmembrane transporter activity Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity L-arginine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0097626 GO:0034028 biolink:MolecularActivity 5-(carboxyamino)imidazole ribonucleotide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate. EC:6.3.4.18|KEGG_REACTION:R07404|MetaCyc:RXN0-742|RHEA:19317 go.json 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity|N5-CAIR synthetase activity|N5-carboxyaminoimidazole ribonucleotide synthetase activity|PurK http://purl.obolibrary.org/obo/GO_0034028 GO:0097625 biolink:MolecularActivity low-affinity basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low affinity basic amino acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0097625 GO:0034027 biolink:MolecularActivity (carboxyethyl)arginine beta-lactam-synthase activity Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H+. EC:6.3.3.4|KEGG_REACTION:R05467|MetaCyc:6.3.3.4-RXN|RHEA:23620 go.json L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity|L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity|beta-lactam synthetase activity http://purl.obolibrary.org/obo/GO_0034027 GO:0010070 biolink:BiologicalProcess zygote asymmetric cell division The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. go.json zygote asymmetric cytokinesis http://purl.obolibrary.org/obo/GO_0010070 GO:0097628 biolink:BiologicalProcess distal tip cell migration The orderly movement of a distal tip cell. go.json http://purl.obolibrary.org/obo/GO_0097628 GO:0034026 biolink:MolecularActivity L-amino-acid alpha-ligase activity Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid. EC:6.3.2.49|MetaCyc:RXN-16296|RHEA:44332 go.json L-amino acid alpha-ligase activity|L-amino acid ligase activity|YwfE|bacilysin synthetase activity http://purl.obolibrary.org/obo/GO_0034026 GO:0097627 biolink:MolecularActivity high-affinity L-ornithine transmembrane transporter activity Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity L-ornithine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0097627 GO:0034025 biolink:MolecularActivity D-aspartate ligase activity Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate. EC:6.3.1.12|MetaCyc:6.3.1.12-RXN|RHEA:10752 go.json D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity|D-aspartic acid-activating enzyme|UDP-MurNAc-pentapeptide:D-aspartate ligase activity|aslfm http://purl.obolibrary.org/obo/GO_0034025 GO:0097622 biolink:BiologicalProcess cytoplasmic translational elongation through polyproline stretches The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0097622 GO:0010072 biolink:BiologicalProcess primary shoot apical meristem specification The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers. go.json embryo shoot apical meristem specification http://purl.obolibrary.org/obo/GO_0010072 GO:0097621 biolink:MolecularActivity monoamine oxidase activity Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. EC:1.4.3.4 go.json amine:oxygen oxidoreductase (deaminating) activity http://purl.obolibrary.org/obo/GO_0097621 GO:0034024 biolink:MolecularActivity glutamate-putrescine ligase activity Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H+ + phosphate. EC:6.3.1.11|KEGG_REACTION:R07414|MetaCyc:RXN0-3901|RHEA:13633 go.json L-glutamate:putrescine ligase (ADP-forming) activity|YcjK|gamma-glutamylputrescine synthetase activity http://purl.obolibrary.org/obo/GO_0034024 GO:0010071 biolink:BiologicalProcess root meristem specification The specification of a meristem which will give rise to a primary or lateral root. go.json http://purl.obolibrary.org/obo/GO_0010071 GO:0034023 biolink:MolecularActivity 5-(carboxyamino)imidazole ribonucleotide mutase activity Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. EC:5.4.99.18|MetaCyc:RXN0-743|RHEA:13193 go.json 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity|N5-CAIR mutase activity|N5-carboxyaminoimidazole ribonucleotide mutase activity|PurE|class I PurE http://purl.obolibrary.org/obo/GO_0034023 GO:0097624 biolink:BiologicalProcess UDP-galactose transmembrane import into Golgi lumen The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane. go.json UDP-galactose import into Golgi lumen http://purl.obolibrary.org/obo/GO_0097624 GO:0010074 biolink:BiologicalProcess maintenance of meristem identity The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. go.json maintenance of meristem cell identity|meristem cell maintenance http://purl.obolibrary.org/obo/GO_0010074 GO:0034022 biolink:MolecularActivity 3-(hydroxyamino)phenol mutase activity Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone. EC:5.4.4.3|KEGG_REACTION:R06988|MetaCyc:5.4.4.3-RXN|RHEA:20577|UM-BBD_enzymeID:e0953 go.json 3-(hydroxyamino)phenol hydroxymutase activity|3-hydroxylaminophenol mutase activity|3HAP mutase activity http://purl.obolibrary.org/obo/GO_0034022 GO:0097623 biolink:BiologicalProcess potassium ion export across plasma membrane The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json potassium export|potassium export across plasma membrane|potassium ion export|potassium ion export from cell http://purl.obolibrary.org/obo/GO_0097623 GO:0010073 biolink:BiologicalProcess meristem maintenance Any process involved in maintaining the identity, size and shape of a meristem. go.json http://purl.obolibrary.org/obo/GO_0010073 GO:0097673 biolink:CellularComponent SCF-Ucc1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae. go.json SCF-YLR224W ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0097673 GO:0097672 biolink:CellularComponent SCF-Pof5 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae). go.json SCF-YDR306C ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0097672 GO:0097675 biolink:CellularComponent SCF-Hrt3/Pof7 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe). go.json http://purl.obolibrary.org/obo/GO_0097675 GO:0097674 biolink:CellularComponent SCF-YLR352W ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097674 GO:0097671 biolink:CellularComponent SCF-YDR131C ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097671 GO:0097670 biolink:CellularComponent SCF-Ufo1/Pof10 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe). go.json http://purl.obolibrary.org/obo/GO_0097670 GO:0034019 biolink:MolecularActivity obsolete capsanthin/capsorubin synthase activity OBSOLETE. Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin. go.json CCS|capsanthin-capsorubin synthase activity|capsanthin/capsorubin synthase activity|ketoxanthophyll synthase activity|violaxanthin-capsorubin isomerase (ketone-forming) activity True http://purl.obolibrary.org/obo/GO_0034019 GO:0009059 biolink:BiologicalProcess macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json biopolymer biosynthetic process|macromolecule anabolism|macromolecule biosynthesis|macromolecule formation|macromolecule synthesis http://purl.obolibrary.org/obo/GO_0009059 goslim_pir GO:0009058 biolink:BiologicalProcess biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. Wikipedia:Anabolism go.json anabolism|biosynthesis|formation|multicellular organismal biosynthetic process|single-organism biosynthetic process|synthesis http://purl.obolibrary.org/obo/GO_0009058 goslim_chembl|goslim_metagenomics|goslim_plant GO:0009057 biolink:BiologicalProcess macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json biopolymer catabolic process|cellular macromolecule catabolic process|cellular macromolecule catabolism|cellular macromolecule degradation|macromolecule breakdown|macromolecule catabolism|macromolecule degradation|multicellular organismal macromolecule catabolic process http://purl.obolibrary.org/obo/GO_0009057 goslim_pir GO:0009056 biolink:BiologicalProcess catabolic process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. Wikipedia:Catabolism go.json breakdown|catabolism|degradation|multicellular organismal catabolic process|single-organism catabolic process http://purl.obolibrary.org/obo/GO_0009056 goslim_agr|goslim_chembl|goslim_plant GO:0009055 biolink:MolecularActivity electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. Reactome:R-HSA-169260|Reactome:R-HSA-2564826 go.json electron acceptor activity|electron carrier|electron donor activity|electron transporter activity http://purl.obolibrary.org/obo/GO_0009055 goslim_metagenomics|goslim_pir GO:0034010 biolink:MolecularActivity sulfolactate sulfo-lyase activity Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite. EC:4.4.1.24|KEGG_REACTION:R07633|MetaCyc:RXN-11691|RHEA:21428 go.json 3-sulfolactate bisulfite-lyase (pyruvate-forming) activity|3-sulfolactate bisulfite-lyase activity|Suy|SuyAB http://purl.obolibrary.org/obo/GO_0034010 GO:0010043 biolink:BiologicalProcess response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. go.json response to zinc http://purl.obolibrary.org/obo/GO_0010043 GO:0009065 biolink:BiologicalProcess glutamine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. go.json glutamine family amino acid breakdown|glutamine family amino acid catabolism|glutamine family amino acid degradation http://purl.obolibrary.org/obo/GO_0009065 GO:0010042 biolink:BiologicalProcess response to manganese ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. go.json response to manganese http://purl.obolibrary.org/obo/GO_0010042 GO:0009064 biolink:BiologicalProcess glutamine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. go.json glutamine family amino acid metabolism http://purl.obolibrary.org/obo/GO_0009064 GO:0010045 biolink:BiologicalProcess response to nickel cation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. go.json response to nickel http://purl.obolibrary.org/obo/GO_0010045 GO:0009063 biolink:BiologicalProcess amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. go.json amino acid breakdown|amino acid catabolism|amino acid degradation|cellular amino acid catabolic process http://purl.obolibrary.org/obo/GO_0009063 GO:0010044 biolink:BiologicalProcess response to aluminum ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. go.json response to aluminium ion|response to aluminum http://purl.obolibrary.org/obo/GO_0010044 GO:0009062 biolink:BiologicalProcess fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. Wikipedia:Fatty_acid_degradation go.json fatty acid breakdown|fatty acid catabolism|fatty acid degradation http://purl.obolibrary.org/obo/GO_0009062 GO:0009061 biolink:BiologicalProcess anaerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. MetaCyc:ANAEROBIC-RESPIRATION|Wikipedia:Anaerobic_respiration|Wikipedia:Cellular_respiration#Anaerobic_respiration go.json http://purl.obolibrary.org/obo/GO_0009061 GO:0010047 biolink:BiologicalProcess fruit dehiscence The process leading to the spontaneous opening of the fruit permitting the escape of seeds. go.json http://purl.obolibrary.org/obo/GO_0010047 GO:0010046 biolink:BiologicalProcess response to mycotoxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi. go.json http://purl.obolibrary.org/obo/GO_0010046 GO:0009060 biolink:BiologicalProcess aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. MetaCyc:PWY-3781|Wikipedia:Cellular_respiration#Aerobic_respiration go.json http://purl.obolibrary.org/obo/GO_0009060 GO:0010049 biolink:BiologicalProcess acquisition of plant reproductive competence The process in which a plant acquires the ability to respond to a floral inductive signal. go.json acquisition of reproductive competence http://purl.obolibrary.org/obo/GO_0010049 GO:0010048 biolink:BiologicalProcess vernalization response The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures. go.json http://purl.obolibrary.org/obo/GO_0010048 GO:0034018 biolink:MolecularActivity ascopyrone tautomerase activity Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose. EC:5.3.2.7|MetaCyc:5.3.3.15-RXN|RHEA:22568 go.json 1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity|1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity|APM tautomerase activity|APTM|ascopyrone P tautomerase activity|ascopyrone intramolecular oxidoreductase activity|ascopyrone isomerase activity http://purl.obolibrary.org/obo/GO_0034018 GO:0034017 biolink:MolecularActivity trans-2-decenoyl-acyl-carrier-protein isomerase activity Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]. EC:5.3.3.14|MetaCyc:5.3.3.14-RXN|RHEA:23568 go.json beta-hydroxydecanoyl thioester dehydrase activity|decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity|trans-2, cis-3 decenoyl-ACP isomerase activity|trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity|trans-2,cis-3-decenoyl-ACP isomerase activity|trans-2-cis-3-decenoyl-ACP isomerase activity|trans-2-decenoyl-ACP isomerase activity http://purl.obolibrary.org/obo/GO_0034017 GO:0034016 biolink:MolecularActivity polyenoic fatty acid isomerase activity Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate. EC:5.3.3.13|KEGG_REACTION:R06502|MetaCyc:5.3.3.13-RXN|RHEA:14889 go.json (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity|(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity|(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity|PFI|eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity http://purl.obolibrary.org/obo/GO_0034016 GO:0034015 biolink:MolecularActivity L-ribulose-5-phosphate 3-epimerase activity Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. EC:5.1.3.22|MetaCyc:LXULRU5P-RXN|RHEA:18497 go.json L-xylulose 5-phosphate 3-epimerase activity|SgaU|UlaE http://purl.obolibrary.org/obo/GO_0034015 GO:0097677 biolink:MolecularActivity STAT family protein binding Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. go.json signal transducers and activators of transcription family protein binding http://purl.obolibrary.org/obo/GO_0097677 GO:0034014 biolink:BiologicalProcess response to triglyceride Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus. go.json response to triacylglyceride|response to triacylglycerol http://purl.obolibrary.org/obo/GO_0034014 GO:0034013 biolink:MolecularActivity aliphatic aldoxime dehydratase activity Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O. EC:4.99.1.5|MetaCyc:4.99.1.5-RXN|RHEA:11316 go.json OxdA|aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity|aliphatic aldoxime hydro-lyase activity http://purl.obolibrary.org/obo/GO_0034013 GO:0097676 biolink:BiologicalProcess histone H3-K36 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone. go.json http://purl.obolibrary.org/obo/GO_0097676 gocheck_do_not_annotate GO:0010041 biolink:BiologicalProcess response to iron(III) ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. go.json response to iron(III) http://purl.obolibrary.org/obo/GO_0010041 GO:0034012 biolink:MolecularActivity FAD-AMP lyase (cyclizing) activity Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate. EC:4.6.1.15|RHEA:13729 go.json FAD AMP-lyase (cyclic-FMN-forming) activity|FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity|FMN cyclase activity http://purl.obolibrary.org/obo/GO_0034012 GO:0097679 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097679 GO:0034011 biolink:MolecularActivity L-cysteate sulfo-lyase activity Catalysis of the reaction: L-cysteate + H2O = NH4 + pyruvate + sulfite. EC:4.4.1.25|KEGG_REACTION:R07634|MetaCyc:4.4.1.25-RXN|RHEA:13441 go.json CuyA|L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity|L-cysteate sulfo-lyase (deaminating) activity http://purl.obolibrary.org/obo/GO_0034011 GO:0010040 biolink:BiologicalProcess response to iron(II) ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. go.json response to iron(II) http://purl.obolibrary.org/obo/GO_0010040 GO:0097678 biolink:MolecularActivity SOCS family protein binding Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions. go.json suppressor of cytokine signaling family protein binding http://purl.obolibrary.org/obo/GO_0097678 GO:0097684 biolink:CellularComponent dinoflagellate antapex The anterior most point of a dinoflagellate hypocone. go.json antapex http://purl.obolibrary.org/obo/GO_0097684 GO:0097683 biolink:CellularComponent dinoflagellate apex The anterior most point of a dinoflagellate epicone. go.json apex http://purl.obolibrary.org/obo/GO_0097683 GO:0097686 biolink:CellularComponent dinoflagellate apical horn A horn-shaped dinoflagellate apex found in thecate species. go.json http://purl.obolibrary.org/obo/GO_0097686 GO:0097685 biolink:CellularComponent dinoflagellate apical groove A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex. go.json apical groove http://purl.obolibrary.org/obo/GO_0097685 GO:0097680 biolink:BiologicalProcess double-strand break repair via classical nonhomologous end joining An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining). go.json C-NHEJ|canonical nonhomologous end joining http://purl.obolibrary.org/obo/GO_0097680 GO:0097682 biolink:MolecularActivity intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts. go.json intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity http://purl.obolibrary.org/obo/GO_0097682 GO:0034009 biolink:MolecularActivity isoprene synthase activity Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene. EC:4.2.3.27|KEGG_REACTION:R08199|MetaCyc:4.2.3.27-RXN|RHEA:13369 go.json ISPC|ISPS|dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity http://purl.obolibrary.org/obo/GO_0034009 GO:0034008 biolink:MolecularActivity R-linalool synthase activity Catalysis of the reaction: geranyl diphosphate + H2O = (R)-linalool + diphosphate. EC:4.2.3.26|KEGG_REACTION:R07632|MetaCyc:4.2.3.26-RXN|RHEA:15809 go.json (-)-3R-linalool synthase activity|(3R)-linalool synthase activity|geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity http://purl.obolibrary.org/obo/GO_0034008 GO:0097681 biolink:BiologicalProcess double-strand break repair via alternative nonhomologous end joining An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. go.json A-NHEJ|MMEJ|alt-NHEJ|double-strand break repair via microhomology-mediated end joining http://purl.obolibrary.org/obo/GO_0097681 GO:0009069 biolink:BiologicalProcess serine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. go.json serine family amino acid metabolism http://purl.obolibrary.org/obo/GO_0009069 GO:0009068 biolink:BiologicalProcess aspartate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. go.json aspartate family amino acid breakdown|aspartate family amino acid catabolism|aspartate family amino acid degradation http://purl.obolibrary.org/obo/GO_0009068 GO:0009067 biolink:BiologicalProcess aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. go.json aspartate family amino acid anabolism|aspartate family amino acid biosynthesis|aspartate family amino acid formation|aspartate family amino acid synthesis http://purl.obolibrary.org/obo/GO_0009067 GO:0009066 biolink:BiologicalProcess aspartate family amino acid metabolic process The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. go.json aspartate family amino acid metabolism http://purl.obolibrary.org/obo/GO_0009066 GO:0009076 biolink:BiologicalProcess obsolete histidine family amino acid biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family. go.json histidine family amino acid anabolism|histidine family amino acid biosynthesis|histidine family amino acid biosynthetic process|histidine family amino acid formation|histidine family amino acid synthesis True http://purl.obolibrary.org/obo/GO_0009076 GO:0010054 biolink:BiologicalProcess trichoblast differentiation The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair. go.json trichoblast cell differentiation http://purl.obolibrary.org/obo/GO_0010054 GO:0010053 biolink:BiologicalProcess root epidermal cell differentiation The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast. go.json http://purl.obolibrary.org/obo/GO_0010053 GO:0009075 biolink:BiologicalProcess obsolete histidine family amino acid metabolic process OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family. go.json histidine family amino acid metabolic process|histidine family amino acid metabolism True http://purl.obolibrary.org/obo/GO_0009075 GO:0009074 biolink:BiologicalProcess aromatic amino acid family catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). go.json aromatic amino acid family breakdown|aromatic amino acid family catabolism|aromatic amino acid family degradation http://purl.obolibrary.org/obo/GO_0009074 GO:0010056 biolink:BiologicalProcess atrichoblast fate specification The process involved in the specification of an atrichoblast. go.json http://purl.obolibrary.org/obo/GO_0010056 GO:0010055 biolink:BiologicalProcess atrichoblast differentiation The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair. go.json http://purl.obolibrary.org/obo/GO_0010055 GO:0009073 biolink:BiologicalProcess aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). MetaCyc:COMPLETE-ARO-PWY go.json aromatic amino acid family anabolism|aromatic amino acid family biosynthesis|aromatic amino acid family biosynthetic process, shikimate pathway|aromatic amino acid family formation|aromatic amino acid family synthesis http://purl.obolibrary.org/obo/GO_0009073 GO:0010058 biolink:BiologicalProcess regulation of atrichoblast fate specification Any process that modulates atrichoblast fate specification. go.json http://purl.obolibrary.org/obo/GO_0010058 GO:0009072 biolink:BiologicalProcess aromatic amino acid metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). go.json aromatic amino acid family metabolic process|aromatic amino acid family metabolism http://purl.obolibrary.org/obo/GO_0009072 GO:0009071 biolink:BiologicalProcess serine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. go.json serine family amino acid breakdown|serine family amino acid catabolism|serine family amino acid degradation http://purl.obolibrary.org/obo/GO_0009071 GO:0010057 biolink:BiologicalProcess trichoblast fate specification The process involved in the specification of a trichoblast. go.json http://purl.obolibrary.org/obo/GO_0010057 GO:0009070 biolink:BiologicalProcess serine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. go.json serine family amino acid anabolism|serine family amino acid biosynthesis|serine family amino acid formation|serine family amino acid synthesis http://purl.obolibrary.org/obo/GO_0009070 GO:0010059 biolink:BiologicalProcess positive regulation of atrichoblast fate specification Any process that induces or promotes atrichoblast fate specification. go.json activation of atrichoblast fate|stimulation of atrichoblast fate|up regulation of atrichoblast fate|up-regulation of atrichoblast fate|upregulation of atrichoblast fate http://purl.obolibrary.org/obo/GO_0010059 GO:0034007 biolink:MolecularActivity S-linalool synthase activity Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate. EC:4.2.3.25|KEGG_REACTION:R07631|MetaCyc:4.2.3.25-RXN|RHEA:24116 go.json 3S-linalool synthase activity|LIS|geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity http://purl.obolibrary.org/obo/GO_0034007 GO:0034006 biolink:MolecularActivity amorpha-4,11-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate. EC:4.2.3.24|KEGG_REACTION:R07630|MetaCyc:RXN-8046|RHEA:18325 go.json 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity|amorphadiene synthase activity http://purl.obolibrary.org/obo/GO_0034006 GO:0034005 biolink:MolecularActivity germacrene-A synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate. EC:4.2.3.23|KEGG_REACTION:R07649|MetaCyc:RXN-11527|RHEA:12516 go.json (+)-(10R)-germacrene A synthase activity|(+)-germacrene A synthase activity|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity|GAS|germacrene A synthase activity http://purl.obolibrary.org/obo/GO_0034005 GO:0034004 biolink:MolecularActivity germacradienol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate. EC:4.2.3.22|KEGG_REACTION:R07647|MetaCyc:RXN-8648|RHEA:22436 go.json 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity http://purl.obolibrary.org/obo/GO_0034004 GO:0097688 biolink:BiologicalProcess glutamate receptor clustering The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane. go.json glutamatergic receptor clustering http://purl.obolibrary.org/obo/GO_0097688 GO:0034003 biolink:MolecularActivity vetispiradiene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene. EC:4.2.3.21|KEGG_REACTION:R06523|MetaCyc:RXN-4823|RHEA:10340 go.json HVS|pemnaspirodiene synthase activity|trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity|vetispiradiene cyclase activity|vetispiradiene-forming farnesyl pyrophosphate cyclase activity http://purl.obolibrary.org/obo/GO_0034003 GO:0010050 biolink:BiologicalProcess vegetative phase change Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. go.json http://purl.obolibrary.org/obo/GO_0010050 GO:0034002 biolink:MolecularActivity (R)-limonene synthase activity Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate. EC:4.2.3.20|KEGG_REACTION:R06120|MetaCyc:4.2.3.20-RXN|RHEA:10940 go.json (+)-limonene synthase activity|geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity|geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity http://purl.obolibrary.org/obo/GO_0034002 GO:0097687 biolink:CellularComponent dinoflagellate antapical horn A horn-shaped dinoflagellate antapex found in thecate species. go.json http://purl.obolibrary.org/obo/GO_0097687 GO:0034001 biolink:MolecularActivity chondroitin-sulfate-ABC exolyase activity Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments. EC:4.2.2.21|MetaCyc:4.2.2.21-RXN go.json ChS ABC lyase II activity|ChS ABC lyase activity|chondroitin ABC eliminase activity|chondroitin sulfate ABC exoeliminase activity|chondroitin sulfate ABC exolyase activity|chondroitin sulfate ABC lyase activity|chondroitinase ABC activity|chondroitinase activity http://purl.obolibrary.org/obo/GO_0034001 GO:0010052 biolink:BiologicalProcess guard cell differentiation The process in which a guard mother cell acquires the specialized features of a guard cell. go.json stomatal cell differentiation http://purl.obolibrary.org/obo/GO_0010052 GO:0034000 biolink:MolecularActivity chondroitin-sulfate-ABC endolyase activity Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides. EC:4.2.2.20|MetaCyc:4.2.2.19-RXN|MetaCyc:4.2.2.5-RXN|MetaCyc:RXN-11572 go.json ChS ABC lyase I activity|ChS ABC lyase activity|chondroitin ABC eliminase activity|chondroitin sulfate ABC endoeliminase activity|chondroitin sulfate ABC endolyase activity|chondroitin sulfate ABC lyase activity|chondroitinase ABC activity|chondroitinase activity http://purl.obolibrary.org/obo/GO_0034000 GO:0010051 biolink:BiologicalProcess xylem and phloem pattern formation The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana. go.json vascular tissue pattern formation http://purl.obolibrary.org/obo/GO_0010051 GO:0097689 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0097689 GO:0097651 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class I A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast. go.json class I PI3K complex|class I phosphatidylinositol 3-kinase complex http://purl.obolibrary.org/obo/GO_0097651 GO:0097650 biolink:CellularComponent B axonemal microtubule An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet. go.json B tubule http://purl.obolibrary.org/obo/GO_0097650 GO:0097653 biolink:CellularComponent unencapsulated part of cell The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures. go.json non-encapsulated part of cell http://purl.obolibrary.org/obo/GO_0097653 GO:0097652 biolink:CellularComponent phosphatidylinositol 3-kinase complex, class II A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast. go.json class II PI3K complex|class II phosphatidylinositol 3-kinase complex http://purl.obolibrary.org/obo/GO_0097652 GO:0010029 biolink:BiologicalProcess regulation of seed germination Any process that modulates the frequency, rate or extent of seed germination. go.json http://purl.obolibrary.org/obo/GO_0010029 GO:0009039 biolink:MolecularActivity urease activity Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. EC:3.5.1.5|MetaCyc:UREASE-RXN|RHEA:20557|UM-BBD_reactionID:r0120 go.json urea amidohydrolase activity http://purl.obolibrary.org/obo/GO_0009039 GO:0010028 biolink:BiologicalProcess xanthophyll cycle A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II. MetaCyc:PWY-5945|Wikipedia:Xanthophyll#Xanthophyll_cycle go.json http://purl.obolibrary.org/obo/GO_0010028 GO:0009038 biolink:MolecularActivity undecaprenol kinase activity Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate. EC:2.7.1.66 go.json ATP:undecaprenol phosphotransferase activity|C55-isoprenoid alcohol kinase activity|C55-isoprenoid alcohol phosphokinase activity|C55-isoprenyl alcohol phosphokinase activity|isoprenoid alcohol kinase (phosphorylating)|isoprenoid alcohol kinase activity|isoprenoid alcohol phosphokinase activity|isoprenoid-alcohol kinase activity|polyisoprenol kinase activity http://purl.obolibrary.org/obo/GO_0009038 GO:0009037 biolink:MolecularActivity tyrosine-based site-specific recombinase activity Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site. go.json site-specific tyrosine recombinase activity|tyrosine recombinase http://purl.obolibrary.org/obo/GO_0009037 GO:0009036 biolink:MolecularActivity type II site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. EC:3.1.21.4|MetaCyc:3.1.21.4-RXN go.json type II restriction enzyme activity http://purl.obolibrary.org/obo/GO_0009036 GO:0009035 biolink:MolecularActivity type I site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. EC:3.1.21.3|MetaCyc:3.1.21.3-RXN go.json ATP-dependent DNase activity|adenosine triphosphate-dependent deoxyribonuclease activity|deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)|deoxyribonuclease (adenosine triphosphate-hydrolyzing)|type I restriction enzyme activity http://purl.obolibrary.org/obo/GO_0009035 GO:0009034 biolink:MolecularActivity tryptophanase activity Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate. EC:4.1.99.1|KEGG_REACTION:R00673|MetaCyc:TRYPDEG-PWY|MetaCyc:TRYPTOPHAN-RXN|RHEA:19553 go.json L-tryptophan indole-lyase (deaminating) activity|L-tryptophan indole-lyase (deaminating; pyruvate forming) activity|L-tryptophan indole-lyase activity|L-tryptophanase activity|TNase activity|tryptophan catabolic process, using tryptophanase|tryptophan catabolism, using tryptophanase http://purl.obolibrary.org/obo/GO_0009034 GO:0009033 biolink:MolecularActivity trimethylamine-N-oxide reductase activity Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O. RHEA:22024 go.json NADH:trimethylamine-N-oxide oxidoreductase|trimethylamine N-oxide reductase|trimethylamine oxidase activity|trimethylamine oxide reductase http://purl.obolibrary.org/obo/GO_0009033 GO:0010021 biolink:BiologicalProcess amylopectin biosynthetic process The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages. go.json amylopectin anabolism|amylopectin biosynthesis|amylopectin formation|amylopectin synthesis http://purl.obolibrary.org/obo/GO_0010021 GO:0009043 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009043 GO:0009042 biolink:MolecularActivity valine-pyruvate transaminase activity Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine. EC:2.6.1.66|KEGG_REACTION:R01215|MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN|RHEA:22912 go.json L-valine:pyruvate aminotransferase activity|alanine--valine transaminase activity|alanine-oxoisovalerate aminotransferase activity|transaminase C activity|valine--pyruvate aminotransferase activity|valine-pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0009042 GO:0010020 biolink:BiologicalProcess chloroplast fission The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis. go.json chloroplast division http://purl.obolibrary.org/obo/GO_0010020 GO:0009041 biolink:MolecularActivity UMP/dUMP kinase activity Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. go.json http://purl.obolibrary.org/obo/GO_0009041 GO:0010023 biolink:BiologicalProcess proanthocyanidin biosynthetic process The chemical reactions and pathways resulting in the formation of proanthocyanidin. MetaCyc:PWY-641 go.json proanthocyanidin anabolism|proanthocyanidin biosynthesis|proanthocyanidin formation|proanthocyanidin synthesis http://purl.obolibrary.org/obo/GO_0010023 GO:0009040 biolink:MolecularActivity ureidoglycolate dehydrogenase activity Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+. EC:1.1.1.154|MetaCyc:R165-RXN go.json (S)-ureidoglycolate:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0009040 GO:0010022 biolink:BiologicalProcess meristem determinacy The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). go.json http://purl.obolibrary.org/obo/GO_0010022 GO:0010025 biolink:BiologicalProcess wax biosynthetic process The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids. MetaCyc:PWY-282 go.json wax anabolism|wax biosynthesis|wax formation|wax synthesis http://purl.obolibrary.org/obo/GO_0010025 GO:0010024 biolink:BiologicalProcess phytochromobilin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha. go.json phytochromobilin anabolism|phytochromobilin biosynthesis|phytochromobilin formation|phytochromobilin synthesis http://purl.obolibrary.org/obo/GO_0010024 GO:0010027 biolink:BiologicalProcess thylakoid membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane. go.json thylakoid membrane organisation|thylakoid membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0010027 GO:0010026 biolink:BiologicalProcess trichome differentiation The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana. go.json trichome cell differentiation http://purl.obolibrary.org/obo/GO_0010026 GO:0097659 biolink:BiologicalProcess obsolete nucleic acid-templated transcription OBSOLETE. The synthesis of an RNA transcript from a nucleic acid template (DNA or RNA). go.json True http://purl.obolibrary.org/obo/GO_0097659 GO:0097658 biolink:CellularComponent Asi complex A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p. go.json http://purl.obolibrary.org/obo/GO_0097658 GO:0097655 biolink:MolecularActivity serpin family protein binding Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors. go.json http://purl.obolibrary.org/obo/GO_0097655 GO:0097654 biolink:CellularComponent platelet SNARE complex A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4. go.json http://purl.obolibrary.org/obo/GO_0097654 GO:0097657 biolink:MolecularActivity 3',5'-nucleotide bisphosphate phosphatase activity Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate. EC:3.1.3.97|RHEA:43532 go.json http://purl.obolibrary.org/obo/GO_0097657 GO:0097656 biolink:BiologicalProcess cell-cell self recognition A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development. go.json kin discrimination|kin recognition|self recognition http://purl.obolibrary.org/obo/GO_0097656 GO:0097662 biolink:CellularComponent SCF-Das1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097662 GO:0097661 biolink:CellularComponent SCF-Ctf13 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097661 GO:0097664 biolink:CellularComponent SCF-Grr1/Pof2 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe). go.json http://purl.obolibrary.org/obo/GO_0097664 GO:0097663 biolink:CellularComponent SCF-Dia2/Pof3 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe). go.json http://purl.obolibrary.org/obo/GO_0097663 GO:0097660 biolink:CellularComponent SCF-Cdc4 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097660 GO:0010039 biolink:BiologicalProcess response to iron ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. go.json response to iron http://purl.obolibrary.org/obo/GO_0010039 GO:0009049 biolink:MolecularActivity obsolete aspartic-type signal peptidase activity OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism. go.json aspartic-type signal peptidase activity True http://purl.obolibrary.org/obo/GO_0009049 GO:0009048 biolink:BiologicalProcess dosage compensation by inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. Wikipedia:X-inactivation go.json Barr body formation|X chromosome inactivation|chromosome inactivation http://purl.obolibrary.org/obo/GO_0009048 GO:0009047 biolink:BiologicalProcess dosage compensation by hyperactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster. Wikipedia:XY_sex-determination_system go.json http://purl.obolibrary.org/obo/GO_0009047 GO:0009046 biolink:MolecularActivity zinc D-Ala-D-Ala carboxypeptidase activity Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine. EC:3.4.17.14|MetaCyc:3.4.17.14-RXN go.json D-alanyl-D-alanine hydrolase activity|D-alanyl-D-alanine-cleaving carboxypeptidase activity|DD-carboxypeptidase|DD-carboxypeptidase-transpeptidase activity|G enzyme|Zn(2+) G peptidase activity|Zn2+ G peptidase activity http://purl.obolibrary.org/obo/GO_0009046 GO:0009045 biolink:MolecularActivity xylose isomerase activity Catalysis of the reaction: D-xylose = D-xylulose. EC:5.3.1.5|MetaCyc:XYLISOM-RXN|RHEA:22816 go.json D-xylose aldose-ketose-isomerase activity|D-xylose isomerase activity|D-xylose ketoisomerase activity|D-xylose ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0009045 GO:0009044 biolink:MolecularActivity xylan 1,4-beta-xylosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini. EC:3.2.1.37|MetaCyc:3.2.1.37-RXN go.json 1,4-beta-D-xylan xylohydrolase activity|beta-D-xylopyranosidase activity|beta-xylosidase activity|exo-1,4-beta-D-xylosidase activity|exo-1,4-beta-xylosidase activity|exo-1,4-xylosidase activity|xylobiase activity http://purl.obolibrary.org/obo/GO_0009044 GO:0009054 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009054 GO:0010032 biolink:BiologicalProcess meiotic chromosome condensation Compaction of chromatin structure prior to meiosis in eukaryotic cells. go.json chromosome condensation involved in meiotic cell cycle http://purl.obolibrary.org/obo/GO_0010032 GO:0009053 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0009053 GO:0010031 biolink:BiologicalProcess circumnutation The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth. go.json http://purl.obolibrary.org/obo/GO_0010031 GO:0009052 biolink:BiologicalProcess pentose-phosphate shunt, non-oxidative branch The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. MetaCyc:NONOXIPENT-PWY|MetaCyc:P21-PWY go.json pentose phosphate pathway, non-oxidative branch|pentose phosphate shunt, non-oxidative branch|pentose-phosphate pathway, non-oxidative branch http://purl.obolibrary.org/obo/GO_0009052 GO:0010034 biolink:BiologicalProcess response to acetate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. go.json http://purl.obolibrary.org/obo/GO_0010034 GO:0010033 biolink:BiologicalProcess response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. go.json process resulting in tolerance to organic substance http://purl.obolibrary.org/obo/GO_0010033 GO:0009051 biolink:BiologicalProcess pentose-phosphate shunt, oxidative branch The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). MetaCyc:OXIDATIVEPENT-PWY go.json oxidative branch, pentose pathway|oxidative pentose phosphate pathway|pentose phosphate pathway, oxidative branch|pentose phosphate shunt, oxidative branch|pentose-phosphate pathway, oxidative branch http://purl.obolibrary.org/obo/GO_0009051 GO:0009050 biolink:BiologicalProcess glycopeptide catabolic process The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide. go.json glycopeptide breakdown|glycopeptide catabolism|glycopeptide degradation http://purl.obolibrary.org/obo/GO_0009050 GO:0010036 biolink:BiologicalProcess response to boron-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus. go.json response to boron http://purl.obolibrary.org/obo/GO_0010036 GO:0010035 biolink:BiologicalProcess response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. go.json http://purl.obolibrary.org/obo/GO_0010035 GO:0010038 biolink:BiologicalProcess response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. go.json heavy metal sensitivity/resistance|response to heavy metal|response to metal http://purl.obolibrary.org/obo/GO_0010038 GO:0010037 biolink:BiologicalProcess response to carbon dioxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0010037 GO:0097669 biolink:CellularComponent SCF-Skp2 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097669 GO:0097666 biolink:CellularComponent SCF-Met30/Pof1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe). go.json http://purl.obolibrary.org/obo/GO_0097666 GO:0097665 biolink:CellularComponent SCF-Mdm30 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0097665 GO:0010030 biolink:BiologicalProcess positive regulation of seed germination Any process that activates or increase the rate of seed germination. go.json activation of seed germination|stimulation of seed germination|up regulation of seed germination|up-regulation of seed germination|upregulation of seed germination http://purl.obolibrary.org/obo/GO_0010030 GO:0097668 biolink:CellularComponent SCF-Saf1/Pof9 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe). go.json http://purl.obolibrary.org/obo/GO_0097668 GO:0097667 biolink:CellularComponent SCF-Rcy1/Pof6 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe). go.json http://purl.obolibrary.org/obo/GO_0097667 GO:0048626 biolink:BiologicalProcess myoblast fate specification The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0048626 GO:0048625 biolink:BiologicalProcess myoblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0048625 GO:0048624 biolink:BiologicalProcess plantlet formation on parent plant The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed. go.json vegetative vivipary|vivipary http://purl.obolibrary.org/obo/GO_0048624 GO:0048623 biolink:BiologicalProcess seed germination on parent plant The process in which a seed germinates before being shed from the parent plant. go.json non-vegetative vivipary|pre-harvest sprouting|vivipary http://purl.obolibrary.org/obo/GO_0048623 GO:0048622 biolink:BiologicalProcess obsolete reproductive sporulation OBSOLETE. The formation of reproductive spores. go.json reproductive sporulation True http://purl.obolibrary.org/obo/GO_0048622 GO:0048621 biolink:BiologicalProcess post-embryonic digestive tract morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. go.json post-embryonic gut morphogenesis http://purl.obolibrary.org/obo/GO_0048621 GO:0048620 biolink:BiologicalProcess post-embryonic hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase. go.json http://purl.obolibrary.org/obo/GO_0048620 GO:0048629 biolink:BiologicalProcess trichome patterning The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes. go.json trichome distribution|trichome pattern biosynthesis|trichome pattern formation|trichome pattern specification|trichome spacing http://purl.obolibrary.org/obo/GO_0048629 GO:0048628 biolink:BiologicalProcess myoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0048628 GO:0048627 biolink:BiologicalProcess myoblast development The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0048627 GO:0048637 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048637 GO:0048636 biolink:BiologicalProcess positive regulation of muscle organ development Any process that activates, maintains or increases the rate of muscle development. go.json activation of muscle development|stimulation of muscle development|up regulation of muscle development|up-regulation of muscle development|upregulation of muscle development http://purl.obolibrary.org/obo/GO_0048636 GO:0048635 biolink:BiologicalProcess negative regulation of muscle organ development Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. go.json down regulation of muscle development|down-regulation of muscle development|downregulation of muscle development|inhibition of muscle development http://purl.obolibrary.org/obo/GO_0048635 GO:0048634 biolink:BiologicalProcess regulation of muscle organ development Any process that modulates the frequency, rate or extent of muscle development. go.json http://purl.obolibrary.org/obo/GO_0048634 GO:0048633 biolink:BiologicalProcess positive regulation of skeletal muscle tissue growth Any process that activates, maintains or increases the rate of skeletal muscle growth. go.json activation of skeletal muscle growth|stimulation of skeletal muscle growth|up regulation of skeletal muscle growth|up-regulation of skeletal muscle growth|upregulation of skeletal muscle growth http://purl.obolibrary.org/obo/GO_0048633 GO:0048632 biolink:BiologicalProcess negative regulation of skeletal muscle tissue growth Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. go.json down regulation of skeletal muscle growth|down-regulation of skeletal muscle growth|downregulation of skeletal muscle growth|inhibition of skeletal muscle growth http://purl.obolibrary.org/obo/GO_0048632 GO:0048631 biolink:BiologicalProcess regulation of skeletal muscle tissue growth Any process that modulates the frequency, rate or extent of skeletal muscle growth. go.json http://purl.obolibrary.org/obo/GO_0048631 GO:0048630 biolink:BiologicalProcess skeletal muscle tissue growth The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. go.json http://purl.obolibrary.org/obo/GO_0048630 GO:0048639 biolink:BiologicalProcess positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth. go.json activation of developmental growth|stimulation of developmental growth|up regulation of developmental growth|up-regulation of developmental growth|upregulation of developmental growth http://purl.obolibrary.org/obo/GO_0048639 GO:0048638 biolink:BiologicalProcess regulation of developmental growth Any process that modulates the frequency, rate or extent of developmental growth. go.json http://purl.obolibrary.org/obo/GO_0048638 GO:0048640 biolink:BiologicalProcess negative regulation of developmental growth Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. go.json down regulation of developmental growth|down-regulation of developmental growth|downregulation of developmental growth|inhibition of developmental growth http://purl.obolibrary.org/obo/GO_0048640 GO:1903809 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903809 GO:1903808 biolink:BiologicalProcess L-tyrosine import across plasma membrane The directed movement of L-tyrosine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-tyrosine import|L-tyrosine import into cell|L-tyrosine uptake http://purl.obolibrary.org/obo/GO_1903808 GO:1903807 biolink:BiologicalProcess L-threonine import across plasma membrane The directed movement of L-threonine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-threonine import|L-threonine import into cell|L-threonine uptake http://purl.obolibrary.org/obo/GO_1903807 GO:1903806 biolink:BiologicalProcess L-isoleucine import across plasma membrane The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-isoleucine import|L-isoleucine import into cell|isoleucine import http://purl.obolibrary.org/obo/GO_1903806 GO:1903805 biolink:BiologicalProcess L-valine import across plasma membrane The directed movement of L-valine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-valine import into cell|valine import http://purl.obolibrary.org/obo/GO_1903805 GO:1903804 biolink:BiologicalProcess glycine import across plasma membrane The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. go.json glycine import|glycine import into cell http://purl.obolibrary.org/obo/GO_1903804 GO:1903803 biolink:BiologicalProcess L-glutamine import across plasma membrane The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-glutamine import|L-glutamine import into cell|L-glutamine uptake http://purl.obolibrary.org/obo/GO_1903803 GO:1903802 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903802 GO:1903801 biolink:BiologicalProcess L-leucine import across plasma membrane The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-leucine import|L-leucine import into cell|L-leucine uptake|leucine import|leucine uptake http://purl.obolibrary.org/obo/GO_1903801 GO:0048648 biolink:BiologicalProcess caste determination The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. go.json http://purl.obolibrary.org/obo/GO_0048648 GO:1903800 biolink:BiologicalProcess positive regulation of miRNA processing Any process that activates or increases the frequency, rate or extent of microRNA processing. go.json activation of gene silencing by miRNA, production of miRNAs|activation of miRNA biogenesis|activation of miRNA processing|activation of miRNA-mediated gene silencing, production of miRNAs|activation of microRNA biogenesis|activation of microRNA biosynthesis|activation of microRNA biosynthetic process|activation of microRNA metabolic process|activation of microRNA metabolism|activation of microRNA-mediated gene silencing, production of microRNAs|activation of production of miRNAs involved in gene silencing by miRNA|activation of production of microRNAs involved in gene silencing by microRNA|positive regulation of gene silencing by miRNA, production of miRNAs|positive regulation of miRNA biogenesis|positive regulation of miRNA maturation|positive regulation of miRNA-mediated gene silencing, production of miRNAs|positive regulation of microRNA biogenesis|positive regulation of microRNA biosynthesis|positive regulation of microRNA biosynthetic process|positive regulation of microRNA metabolic process|positive regulation of microRNA metabolism|positive regulation of microRNA-mediated gene silencing, production of microRNAs|positive regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of production of microRNAs involved in gene silencing by microRNA http://purl.obolibrary.org/obo/GO_1903800 GO:0048647 biolink:BiologicalProcess polyphenic determination The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues. go.json http://purl.obolibrary.org/obo/GO_0048647 GO:0048646 biolink:BiologicalProcess anatomical structure formation involved in morphogenesis The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. go.json formation of an anatomical structure involved in morphogenesis http://purl.obolibrary.org/obo/GO_0048646 goslim_chembl GO:0048645 biolink:BiologicalProcess animal organ formation The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. go.json animal organ primordium initiation|initiation of an animal organ primordium http://purl.obolibrary.org/obo/GO_0048645 GO:0048644 biolink:BiologicalProcess muscle organ morphogenesis The process in which the anatomical structures of muscle are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048644 GO:0048643 biolink:BiologicalProcess positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development. go.json activation of skeletal muscle development|stimulation of skeletal muscle development|up regulation of skeletal muscle development|up-regulation of skeletal muscle development|upregulation of skeletal muscle development http://purl.obolibrary.org/obo/GO_0048643 GO:0048642 biolink:BiologicalProcess negative regulation of skeletal muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. go.json down regulation of skeletal muscle development|down-regulation of skeletal muscle development|downregulation of skeletal muscle development|inhibition of skeletal muscle development http://purl.obolibrary.org/obo/GO_0048642 GO:0048641 biolink:BiologicalProcess regulation of skeletal muscle tissue development Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. go.json http://purl.obolibrary.org/obo/GO_0048641 GO:0048649 biolink:BiologicalProcess caste determination, influence by genetic factors The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. go.json http://purl.obolibrary.org/obo/GO_0048649 GO:0048651 biolink:BiologicalProcess polyphenic determination, influence by environmental factors The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues. go.json http://purl.obolibrary.org/obo/GO_0048651 GO:0048650 biolink:BiologicalProcess caste determination, influence by environmental factors The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. go.json http://purl.obolibrary.org/obo/GO_0048650 GO:1903819 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic cytokinesis checkpoint OBSOLETE. Any detection of stimulus that is involved in a mitotic cytokinesis checkpoint. go.json perception of stimulus involved in mitotic cytokinesis checkpoint|stimulus detection involved in mitotic cytokinesis checkpoint|stimulus sensing involved in mitotic cytokinesis checkpoint True http://purl.obolibrary.org/obo/GO_1903819 GO:1903818 biolink:BiologicalProcess positive regulation of voltage-gated potassium channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity. go.json activation of voltage gated potassium channel activity|activation of voltage-dependent potassium channel activity|activation of voltage-gated potassium channel activity|activation of voltage-gated potassium ion channel activity|activation of voltage-sensitive potassium channel|positive regulation of voltage gated potassium channel activity|positive regulation of voltage-dependent potassium channel activity|positive regulation of voltage-gated potassium ion channel activity|positive regulation of voltage-sensitive potassium channel|up regulation of voltage gated potassium channel activity|up regulation of voltage-dependent potassium channel activity|up regulation of voltage-gated potassium channel activity|up regulation of voltage-gated potassium ion channel activity|up regulation of voltage-sensitive potassium channel|up-regulation of voltage gated potassium channel activity|up-regulation of voltage-dependent potassium channel activity|up-regulation of voltage-gated potassium channel activity|up-regulation of voltage-gated potassium ion channel activity|up-regulation of voltage-sensitive potassium channel|upregulation of voltage gated potassium channel activity|upregulation of voltage-dependent potassium channel activity|upregulation of voltage-gated potassium channel activity|upregulation of voltage-gated potassium ion channel activity|upregulation of voltage-sensitive potassium channel http://purl.obolibrary.org/obo/GO_1903818 gocheck_do_not_annotate GO:1903817 biolink:BiologicalProcess negative regulation of voltage-gated potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity. go.json down regulation of voltage gated potassium channel activity|down regulation of voltage-dependent potassium channel activity|down regulation of voltage-gated potassium channel activity|down regulation of voltage-gated potassium ion channel activity|down regulation of voltage-sensitive potassium channel|down-regulation of voltage gated potassium channel activity|down-regulation of voltage-dependent potassium channel activity|down-regulation of voltage-gated potassium channel activity|down-regulation of voltage-gated potassium ion channel activity|down-regulation of voltage-sensitive potassium channel|downregulation of voltage gated potassium channel activity|downregulation of voltage-dependent potassium channel activity|downregulation of voltage-gated potassium channel activity|downregulation of voltage-gated potassium ion channel activity|downregulation of voltage-sensitive potassium channel|inhibition of voltage gated potassium channel activity|inhibition of voltage-dependent potassium channel activity|inhibition of voltage-gated potassium channel activity|inhibition of voltage-gated potassium ion channel activity|inhibition of voltage-sensitive potassium channel|negative regulation of voltage gated potassium channel activity|negative regulation of voltage-dependent potassium channel activity|negative regulation of voltage-gated potassium ion channel activity|negative regulation of voltage-sensitive potassium channel http://purl.obolibrary.org/obo/GO_1903817 gocheck_do_not_annotate GO:1903816 biolink:BiologicalProcess positive regulation of collecting lymphatic vessel constriction Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction. go.json activation of collecting lymphatic vessel constriction|activation of lymphatic vessel myogenic constriction|positive regulation of lymphatic vessel myogenic constriction|up regulation of collecting lymphatic vessel constriction|up regulation of lymphatic vessel myogenic constriction|up-regulation of collecting lymphatic vessel constriction|up-regulation of lymphatic vessel myogenic constriction|upregulation of collecting lymphatic vessel constriction|upregulation of lymphatic vessel myogenic constriction http://purl.obolibrary.org/obo/GO_1903816 GO:1903815 biolink:BiologicalProcess negative regulation of collecting lymphatic vessel constriction Any process that stops, prevents or reduces the frequency, rate or extent of collecting lymphatic vessel constriction. go.json down regulation of collecting lymphatic vessel constriction|down regulation of lymphatic vessel myogenic constriction|down-regulation of collecting lymphatic vessel constriction|down-regulation of lymphatic vessel myogenic constriction|downregulation of collecting lymphatic vessel constriction|downregulation of lymphatic vessel myogenic constriction|inhibition of collecting lymphatic vessel constriction|inhibition of lymphatic vessel myogenic constriction|negative regulation of lymphatic vessel myogenic constriction http://purl.obolibrary.org/obo/GO_1903815 GO:1903814 biolink:BiologicalProcess regulation of collecting lymphatic vessel constriction Any process that modulates the frequency, rate or extent of collecting lymphatic vessel constriction. go.json regulation of lymphatic vessel myogenic constriction http://purl.obolibrary.org/obo/GO_1903814 GO:1903813 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903813 GO:1903812 biolink:BiologicalProcess L-serine import across plasma membrane The directed movement of L-serine into a cell. go.json L-serine import into cell http://purl.obolibrary.org/obo/GO_1903812 GO:0048659 biolink:BiologicalProcess smooth muscle cell proliferation The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. go.json SMC proliferation http://purl.obolibrary.org/obo/GO_0048659 GO:1903811 biolink:BiologicalProcess L-asparagine import across plasma membrane The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-asparagine import into cell|asparagine import http://purl.obolibrary.org/obo/GO_1903811 GO:0048658 biolink:BiologicalProcess anther wall tapetum development The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure. go.json tapetal layer development|tapetum development http://purl.obolibrary.org/obo/GO_0048658 GO:1903810 biolink:BiologicalProcess L-histidine import across plasma membrane The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol. go.json L-histidine import|L-histidine import into cell|histidine import http://purl.obolibrary.org/obo/GO_1903810 GO:0048657 biolink:BiologicalProcess anther wall tapetum cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. go.json tapetal cell differentiation http://purl.obolibrary.org/obo/GO_0048657 GO:0048656 biolink:BiologicalProcess anther wall tapetum formation The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. go.json tapetal layer formation|tapetum formation http://purl.obolibrary.org/obo/GO_0048656 GO:0048655 biolink:BiologicalProcess anther wall tapetum morphogenesis The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. go.json differentiation of tapetal layer|tapetal layer morphogenesis|tapetum morphogenesis http://purl.obolibrary.org/obo/GO_0048655 GO:0048654 biolink:BiologicalProcess anther morphogenesis The process in which the anatomical structures of the anther are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0048654 GO:0048653 biolink:BiologicalProcess anther development The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0048653 GO:0048652 biolink:BiologicalProcess polyphenic determination, influence by genetic factors The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues. go.json http://purl.obolibrary.org/obo/GO_0048652 GO:0048662 biolink:BiologicalProcess negative regulation of smooth muscle cell proliferation Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. go.json down regulation of smooth muscle cell proliferation|down-regulation of smooth muscle cell proliferation|downregulation of smooth muscle cell proliferation|inhibition of smooth muscle cell proliferation|negative regulation of SMC proliferation http://purl.obolibrary.org/obo/GO_0048662 GO:0048661 biolink:BiologicalProcess positive regulation of smooth muscle cell proliferation Any process that activates or increases the rate or extent of smooth muscle cell proliferation. go.json activation of smooth muscle cell proliferation|positive regulation of SMC proliferation|stimulation of smooth muscle cell proliferation|up regulation of smooth muscle cell proliferation|up-regulation of smooth muscle cell proliferation|upregulation of smooth muscle cell proliferation http://purl.obolibrary.org/obo/GO_0048661 GO:1903829 biolink:BiologicalProcess positive regulation of protein localization Any process that activates or increases the frequency, rate or extent of a protein localization. go.json positive regulation of cellular protein localisation|positive regulation of cellular protein localization|up regulation of cellular protein localisation|up regulation of cellular protein localization|up-regulation of cellular protein localisation|up-regulation of cellular protein localization|upregulation of cellular protein localisation|upregulation of cellular protein localization http://purl.obolibrary.org/obo/GO_1903829 GO:0048660 biolink:BiologicalProcess regulation of smooth muscle cell proliferation Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. go.json regulation of SMC proliferation http://purl.obolibrary.org/obo/GO_0048660 GO:1903828 biolink:BiologicalProcess negative regulation of protein localization Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. go.json down regulation of cellular protein localisation|down regulation of cellular protein localization|down-regulation of cellular protein localisation|down-regulation of cellular protein localization|downregulation of cellular protein localisation|downregulation of cellular protein localization|inhibition of cellular protein localisation|inhibition of cellular protein localization|negative regulation of cellular protein localisation|negative regulation of cellular protein localization http://purl.obolibrary.org/obo/GO_1903828 GO:1903827 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903827 GO:1903826 biolink:BiologicalProcess L-arginine transmembrane transport The directed movement of L-arginine across a membrane. go.json L-arginine import|L-arginine transport|L-arginine uptake|arginine transmembrane transport|arginine transport http://purl.obolibrary.org/obo/GO_1903826 GO:1903825 biolink:BiologicalProcess organic acid transmembrane transport The process in which an organic acid is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903825 GO:1903824 biolink:BiologicalProcess negative regulation of telomere single strand break repair Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair. go.json down regulation of single strand break repair in telomere|down regulation of telomere SSBR|down regulation of telomere single strand break repair|down regulation of telomere single-strand break repair|down regulation of telomeric single strand break repair|down-regulation of single strand break repair in telomere|down-regulation of telomere SSBR|down-regulation of telomere single strand break repair|down-regulation of telomere single-strand break repair|down-regulation of telomeric single strand break repair|downregulation of single strand break repair in telomere|downregulation of telomere SSBR|downregulation of telomere single strand break repair|downregulation of telomere single-strand break repair|downregulation of telomeric single strand break repair|inhibition of single strand break repair in telomere|inhibition of telomere SSBR|inhibition of telomere single strand break repair|inhibition of telomere single-strand break repair|inhibition of telomeric single strand break repair|negative regulation of single strand break repair in telomere|negative regulation of telomere SSBR|negative regulation of telomere single-strand break repair|negative regulation of telomeric single strand break repair http://purl.obolibrary.org/obo/GO_1903824 GO:1903823 biolink:BiologicalProcess telomere single strand break repair Single strand break repair that takes place in a telomere. go.json single strand break repair in telomere|telomere SSBR|telomere single-strand break repair|telomeric single strand break repair http://purl.obolibrary.org/obo/GO_1903823 GO:0048669 biolink:BiologicalProcess collateral sprouting in absence of injury The process in which outgrowths develop from the axons of intact undamaged neurons. go.json http://purl.obolibrary.org/obo/GO_0048669 GO:1903822 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903822 GO:1903821 biolink:BiologicalProcess obsolete detection of stimulus involved in morphogenesis checkpoint OBSOLETE. Any detection of stimulus that is involved in morphogenesis checkpoint. go.json detection of stimulus involved in septin checkpoint|perception of stimulus involved in morphogenesis checkpoint|perception of stimulus involved in septin checkpoint|stimulus detection involved in morphogenesis checkpoint|stimulus detection involved in septin checkpoint|stimulus sensing involved in morphogenesis checkpoint|stimulus sensing involved in septin checkpoint True http://purl.obolibrary.org/obo/GO_1903821 GO:0048668 biolink:BiologicalProcess collateral sprouting The process in which outgrowths develop from the shafts of existing axons. go.json axon branching http://purl.obolibrary.org/obo/GO_0048668 GO:0048667 biolink:BiologicalProcess cell morphogenesis involved in neuron differentiation The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. go.json neuron morphogenesis involved in differentiation http://purl.obolibrary.org/obo/GO_0048667 GO:1903820 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903820 GO:0048666 biolink:BiologicalProcess neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0048666 GO:0048665 biolink:BiologicalProcess neuron fate specification The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0048665 GO:0048664 biolink:BiologicalProcess neuron fate determination The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0048664 GO:0048663 biolink:BiologicalProcess neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. go.json neuron lineage restriction|neuronal lineage restriction http://purl.obolibrary.org/obo/GO_0048663 GO:0034098 biolink:CellularComponent VCP-NPL4-UFD1 AAA ATPase complex A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). go.json Cdc48p-Npl4p-Ufd1p AAA ATPase complex|p97-Ufd1-Npl4 complex http://purl.obolibrary.org/obo/GO_0034098 GO:0034097 biolink:BiologicalProcess response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. go.json response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0034097 GO:0034096 biolink:BiologicalProcess positive regulation of maintenance of meiotic sister chromatid cohesion Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034096 GO:0034095 biolink:BiologicalProcess negative regulation of maintenance of meiotic sister chromatid cohesion Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034095 GO:0034094 biolink:BiologicalProcess regulation of maintenance of meiotic sister chromatid cohesion Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034094 GO:0034093 biolink:BiologicalProcess positive regulation of maintenance of sister chromatid cohesion Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained. go.json http://purl.obolibrary.org/obo/GO_0034093 GO:0034092 biolink:BiologicalProcess negative regulation of maintenance of sister chromatid cohesion Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained. go.json http://purl.obolibrary.org/obo/GO_0034092 GO:0034091 biolink:BiologicalProcess regulation of maintenance of sister chromatid cohesion Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained. go.json http://purl.obolibrary.org/obo/GO_0034091 GO:0034099 biolink:CellularComponent luminal surveillance complex A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins. go.json http://purl.obolibrary.org/obo/GO_0034099 GO:0048673 biolink:BiologicalProcess collateral sprouting of intact axon in response to injury The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input. go.json http://purl.obolibrary.org/obo/GO_0048673 GO:0048672 biolink:BiologicalProcess positive regulation of collateral sprouting Any process that activates or increases the frequency, rate or extent of collateral sprouting. go.json activation of collateral sprouting|stimulation of collateral sprouting|up regulation of collateral sprouting|up-regulation of collateral sprouting|upregulation of collateral sprouting http://purl.obolibrary.org/obo/GO_0048672 GO:0048671 biolink:BiologicalProcess negative regulation of collateral sprouting Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting. go.json down regulation of collateral sprouting|down-regulation of collateral sprouting|downregulation of collateral sprouting|inhibition of collateral sprouting http://purl.obolibrary.org/obo/GO_0048671 GO:1903839 biolink:BiologicalProcess positive regulation of mRNA 3'-UTR binding Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding. go.json activation of mRNA 3' UTR binding|activation of mRNA 3'-UTR binding|positive regulation of mRNA 3' UTR binding|up regulation of mRNA 3' UTR binding|up regulation of mRNA 3'-UTR binding|up-regulation of mRNA 3' UTR binding|up-regulation of mRNA 3'-UTR binding|upregulation of mRNA 3' UTR binding|upregulation of mRNA 3'-UTR binding http://purl.obolibrary.org/obo/GO_1903839 gocheck_do_not_annotate GO:0048670 biolink:BiologicalProcess regulation of collateral sprouting Any process that modulates the frequency, rate or extent of collateral sprouting. go.json http://purl.obolibrary.org/obo/GO_0048670 GO:1903838 biolink:BiologicalProcess negative regulation of mRNA 3'-UTR binding Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding. go.json down regulation of mRNA 3' UTR binding|down regulation of mRNA 3'-UTR binding|down-regulation of mRNA 3' UTR binding|down-regulation of mRNA 3'-UTR binding|downregulation of mRNA 3' UTR binding|downregulation of mRNA 3'-UTR binding|inhibition of mRNA 3' UTR binding|inhibition of mRNA 3'-UTR binding|negative regulation of mRNA 3' UTR binding http://purl.obolibrary.org/obo/GO_1903838 gocheck_do_not_annotate GO:1903837 biolink:BiologicalProcess regulation of mRNA 3'-UTR binding Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding. go.json regulation of mRNA 3' UTR binding http://purl.obolibrary.org/obo/GO_1903837 gocheck_do_not_annotate GO:1903835 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903835 GO:0034090 biolink:BiologicalProcess maintenance of meiotic sister chromatid cohesion The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034090 GO:1903834 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903834 GO:1903833 biolink:BiologicalProcess positive regulation of cellular response to amino acid starvation Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation. go.json activation of cellular response to amino acid starvation|up regulation of cellular response to amino acid starvation|up-regulation of cellular response to amino acid starvation|upregulation of cellular response to amino acid starvation http://purl.obolibrary.org/obo/GO_1903833 GO:0048679 biolink:BiologicalProcess regulation of axon regeneration Any process that modulates the frequency, rate or extent of axon regeneration. go.json http://purl.obolibrary.org/obo/GO_0048679 GO:1903832 biolink:BiologicalProcess regulation of cellular response to amino acid starvation Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation. go.json http://purl.obolibrary.org/obo/GO_1903832 GO:1903831 biolink:BiologicalProcess signal transduction involved in cellular response to ammonium ion Any signal transduction that is involved in cellular response to ammonium ion. go.json signaling cascade involved in cellular response to ammonium ion|signaling pathway involved in cellular response to ammonium ion|signalling cascade involved in cellular response to ammonium ion|signalling pathway involved in cellular response to ammonium ion http://purl.obolibrary.org/obo/GO_1903831 GO:0048678 biolink:BiologicalProcess response to axon injury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. go.json http://purl.obolibrary.org/obo/GO_0048678 GO:1903830 biolink:BiologicalProcess magnesium ion transmembrane transport The directed movement of magnesium ion across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903830 GO:0048677 biolink:BiologicalProcess axon extension involved in regeneration Long distance growth of a single axon process involved in regeneration of the neuron. go.json http://purl.obolibrary.org/obo/GO_0048677 GO:0048676 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0048676 GO:0048675 biolink:BiologicalProcess axon extension Long distance growth of a single axon process involved in cellular development. go.json axon extension involved in development http://purl.obolibrary.org/obo/GO_0048675 GO:0048674 biolink:BiologicalProcess collateral sprouting of injured axon The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons. go.json http://purl.obolibrary.org/obo/GO_0048674 GO:0034087 biolink:BiologicalProcess establishment of mitotic sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034087 GO:0034086 biolink:BiologicalProcess maintenance of sister chromatid cohesion The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate. go.json http://purl.obolibrary.org/obo/GO_0034086 GO:0034085 biolink:BiologicalProcess establishment of sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase. go.json http://purl.obolibrary.org/obo/GO_0034085 GO:0034084 biolink:MolecularActivity steryl deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol. go.json sterol deacetylase activity http://purl.obolibrary.org/obo/GO_0034084 GO:0097608 biolink:CellularComponent transverse flagellum A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum. go.json transverse cilium http://purl.obolibrary.org/obo/GO_0097608 GO:0034083 biolink:CellularComponent type III polyketide synthase complex A polyketide synthase complex that consists of two identical ketosynthase polypeptides. go.json type III PKS|type III PKS complex|type III polyketide synthase http://purl.obolibrary.org/obo/GO_0034083 GO:0034082 biolink:CellularComponent type II polyketide synthase complex A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction. go.json type II PKS|type II PKS complex|type II polyketide synthase http://purl.obolibrary.org/obo/GO_0034082 GO:0097607 biolink:BiologicalProcess obsolete negative regulation of nuclear envelope permeability OBSOLETE. Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope. go.json negative regulation of nuclear membrane permeability True http://purl.obolibrary.org/obo/GO_0097607 GO:0034081 biolink:CellularComponent polyketide synthase complex A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones. go.json PKS|PKS complex http://purl.obolibrary.org/obo/GO_0034081 GO:0034080 biolink:BiologicalProcess CENP-A containing chromatin assembly The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. go.json CENP-A containing chromatin organization|CENP-A containing nucleosome assembly|CENP-A containing nucleosome assembly at centromere|CENP-A deposition|CENP-A loading|CenH3-containing nucleosome assembly at centromere|DNA replication-independent nucleosome assembly at centromere|centromere specific nucleosome exchange|centromere-specific histone exchange|centromeric DNA replication-independent nucleosome assembly|centromeric chromatin organization http://purl.obolibrary.org/obo/GO_0034080 GO:0097609 biolink:CellularComponent longitudinal flagellum A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus. go.json longitudinal cilium http://purl.obolibrary.org/obo/GO_0097609 GO:0097604 biolink:MolecularActivity temperature-gated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). go.json heat-activated cation channel activity|temperature gated cation channel activity|temperature-activated cation channel activity|temperature-dependent cation channel activity http://purl.obolibrary.org/obo/GO_0097604 GO:0097603 biolink:MolecularActivity temperature-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). go.json heat-activated ion channel activity|temperature gated ion channel activity|temperature-activated ion channel activity|temperature-dependent ion channel activity http://purl.obolibrary.org/obo/GO_0097603 GO:0097606 biolink:BiologicalProcess obsolete positive regulation of nuclear envelope permeability OBSOLETE. Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope. go.json positive regulation of nuclear membrane permeability True http://purl.obolibrary.org/obo/GO_0097606 GO:0097605 biolink:BiologicalProcess obsolete regulation of nuclear envelope permeability OBSOLETE. Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope. go.json regulation of nuclear membrane permeability True http://purl.obolibrary.org/obo/GO_0097605 GO:0097600 biolink:MolecularActivity exoxylanase activity A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains. go.json http://purl.obolibrary.org/obo/GO_0097600 GO:0097602 biolink:MolecularActivity cullin family protein binding Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). go.json cullin binding http://purl.obolibrary.org/obo/GO_0097602 GO:0034089 biolink:BiologicalProcess establishment of meiotic sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0034089 GO:0097601 biolink:BiologicalProcess retina blood vessel maintenance A retina homeostatic process preventing the degeneration of a retina blood vessel. go.json maintenance of choriocapillaris|maintenance of retina blood vessel|maintenance of retinal blood vessel http://purl.obolibrary.org/obo/GO_0097601 GO:0034088 biolink:BiologicalProcess maintenance of mitotic sister chromatid cohesion The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. go.json mitotic cohesion stability http://purl.obolibrary.org/obo/GO_0034088 GO:0048684 biolink:BiologicalProcess positive regulation of collateral sprouting of intact axon in response to injury Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon. go.json activation of collateral sprouting of intact axon in response to injury|stimulation of collateral sprouting of intact axon in response to injury|up regulation of collateral sprouting of intact axon in response to injury|up-regulation of collateral sprouting of intact axon in response to injury|upregulation of collateral sprouting of intact axon in response to injury http://purl.obolibrary.org/obo/GO_0048684 GO:0048683 biolink:BiologicalProcess regulation of collateral sprouting of intact axon in response to injury Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon. go.json http://purl.obolibrary.org/obo/GO_0048683 GO:0048682 biolink:BiologicalProcess sprouting of injured axon The process involved in sprouting of an injured axon. go.json http://purl.obolibrary.org/obo/GO_0048682 GO:0048681 biolink:BiologicalProcess negative regulation of axon regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration. go.json down regulation of axon regeneration|down-regulation of axon regeneration|downregulation of axon regeneration|inhibition of axon regeneration http://purl.obolibrary.org/obo/GO_0048681 GO:1903849 biolink:BiologicalProcess positive regulation of aorta morphogenesis Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. go.json activation of aorta morphogenesis|up regulation of aorta morphogenesis|up-regulation of aorta morphogenesis|upregulation of aorta morphogenesis http://purl.obolibrary.org/obo/GO_1903849 GO:0048680 biolink:BiologicalProcess positive regulation of axon regeneration Any process that activates, maintains or increases the rate of axon regeneration. go.json activation of axon regeneration|stimulation of axon regeneration|up regulation of axon regeneration|up-regulation of axon regeneration|upregulation of axon regeneration http://purl.obolibrary.org/obo/GO_0048680 GO:1903848 biolink:BiologicalProcess negative regulation of aorta morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. go.json down regulation of aorta morphogenesis|down-regulation of aorta morphogenesis|downregulation of aorta morphogenesis|inhibition of aorta morphogenesis http://purl.obolibrary.org/obo/GO_1903848 GO:1903847 biolink:BiologicalProcess regulation of aorta morphogenesis Any process that modulates the frequency, rate or extent of aorta morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1903847 GO:1903846 biolink:BiologicalProcess positive regulation of cellular response to transforming growth factor beta stimulus Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. go.json activation of cellular response to TGF-beta stimulus|activation of cellular response to TGFbeta stimulus|activation of cellular response to transforming growth factor beta stimulus|positive regulation of cellular response to TGF-beta stimulus|positive regulation of cellular response to TGFbeta stimulus|up regulation of cellular response to TGF-beta stimulus|up regulation of cellular response to TGFbeta stimulus|up regulation of cellular response to transforming growth factor beta stimulus|up-regulation of cellular response to TGF-beta stimulus|up-regulation of cellular response to TGFbeta stimulus|up-regulation of cellular response to transforming growth factor beta stimulus|upregulation of cellular response to TGF-beta stimulus|upregulation of cellular response to TGFbeta stimulus|upregulation of cellular response to transforming growth factor beta stimulus http://purl.obolibrary.org/obo/GO_1903846 GO:1903845 biolink:BiologicalProcess negative regulation of cellular response to transforming growth factor beta stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. go.json down regulation of cellular response to TGF-beta stimulus|down regulation of cellular response to TGFbeta stimulus|down regulation of cellular response to transforming growth factor beta stimulus|down-regulation of cellular response to TGF-beta stimulus|down-regulation of cellular response to TGFbeta stimulus|down-regulation of cellular response to transforming growth factor beta stimulus|downregulation of cellular response to TGF-beta stimulus|downregulation of cellular response to TGFbeta stimulus|downregulation of cellular response to transforming growth factor beta stimulus|inhibition of cellular response to TGF-beta stimulus|inhibition of cellular response to TGFbeta stimulus|inhibition of cellular response to transforming growth factor beta stimulus|negative regulation of cellular response to TGF-beta stimulus|negative regulation of cellular response to TGFbeta stimulus http://purl.obolibrary.org/obo/GO_1903845 GO:1903844 biolink:BiologicalProcess regulation of cellular response to transforming growth factor beta stimulus Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. go.json regulation of cellular response to TGF-beta stimulus|regulation of cellular response to TGFbeta stimulus http://purl.obolibrary.org/obo/GO_1903844 GO:1903843 biolink:BiologicalProcess cellular response to arsenite ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus. go.json http://purl.obolibrary.org/obo/GO_1903843 GO:1903842 biolink:BiologicalProcess response to arsenite ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus. go.json http://purl.obolibrary.org/obo/GO_1903842 GO:0048689 biolink:BiologicalProcess formation of growth cone in injured axon The formation of a growth cone in an injured axon. go.json http://purl.obolibrary.org/obo/GO_0048689 GO:0048688 biolink:BiologicalProcess negative regulation of sprouting of injured axon Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon. go.json down regulation of sprouting of injured axon|down-regulation of sprouting of injured axon|downregulation of sprouting of injured axon|inhibition of sprouting of injured axon http://purl.obolibrary.org/obo/GO_0048688 GO:1903841 biolink:BiologicalProcess cellular response to arsenite(3-) Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus. go.json http://purl.obolibrary.org/obo/GO_1903841 GO:0048687 biolink:BiologicalProcess positive regulation of sprouting of injured axon Any process that activates, maintains or increases the rate of sprouting of an injured axon. go.json activation of sprouting of injured axon|stimulation of sprouting of injured axon|up regulation of sprouting of injured axon|up-regulation of sprouting of injured axon|upregulation of sprouting of injured axon http://purl.obolibrary.org/obo/GO_0048687 GO:1903840 biolink:BiologicalProcess response to arsenite(3-) Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus. go.json http://purl.obolibrary.org/obo/GO_1903840 GO:0048686 biolink:BiologicalProcess regulation of sprouting of injured axon Any process that modulates the frequency, rate or extent of sprouting of an injured axon. go.json http://purl.obolibrary.org/obo/GO_0048686 GO:0048685 biolink:BiologicalProcess negative regulation of collateral sprouting of intact axon in response to injury Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon. go.json down regulation of collateral sprouting of intact axon in response to injury|down-regulation of collateral sprouting of intact axon in response to injury|downregulation of collateral sprouting of intact axon in response to injury|inhibition of collateral sprouting of intact axon in response to injury http://purl.obolibrary.org/obo/GO_0048685 GO:0034076 biolink:MolecularActivity cucurbitadienol synthase activity Catalysis of the reaction: oxidosqualene = cucurbitadienol. go.json http://purl.obolibrary.org/obo/GO_0034076 GO:0034075 biolink:MolecularActivity arabidiol synthase activity Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). EC:4.2.1.124|MetaCyc:RXN-9684|RHEA:31035 go.json http://purl.obolibrary.org/obo/GO_0034075 GO:0034074 biolink:MolecularActivity marneral synthase activity Catalysis of the reaction: oxidosqualene = marneral. MetaCyc:RXN-9664|RHEA:31875 go.json http://purl.obolibrary.org/obo/GO_0034074 GO:0034073 biolink:MolecularActivity tetrahymanol cyclase activity Catalysis of the reaction: squalene = tetrahymanol. go.json http://purl.obolibrary.org/obo/GO_0034073 GO:0034072 biolink:MolecularActivity squalene cyclase activity Catalysis of the reaction: squalene = triterpene. go.json http://purl.obolibrary.org/obo/GO_0034072 GO:0034071 biolink:MolecularActivity aminoglycoside phosphotransferase activity Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside. EC:2.7.1.190 go.json aminoglycoside kinase activity http://purl.obolibrary.org/obo/GO_0034071 GO:0034070 biolink:MolecularActivity aminoglycoside 1-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring. go.json http://purl.obolibrary.org/obo/GO_0034070 GO:0034079 biolink:BiologicalProcess butanediol biosynthetic process The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. MetaCyc:P125-PWY go.json butanediol anabolism|butanediol biosynthesis|butanediol formation|butanediol synthesis|butylene glycol biosynthesis|butylene glycol biosynthetic process http://purl.obolibrary.org/obo/GO_0034079 GO:0034078 biolink:BiologicalProcess butanediol catabolic process The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. go.json butanediol breakdown|butanediol catabolism|butanediol degradation|butanediol utilization|butylene glycol catabolic process|butylene glycol catabolism http://purl.obolibrary.org/obo/GO_0034078 GO:0034077 biolink:BiologicalProcess butanediol metabolic process The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. go.json butanediol metabolism|butylene glycol metabolic process|butylene glycol metabolism http://purl.obolibrary.org/obo/GO_0034077 GO:0048695 biolink:BiologicalProcess negative regulation of collateral sprouting of injured axon Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon. go.json down regulation of collateral sprouting of injured axon|down-regulation of collateral sprouting of injured axon|downregulation of collateral sprouting of injured axon|inhibition of collateral sprouting of injured axon http://purl.obolibrary.org/obo/GO_0048695 GO:0048694 biolink:BiologicalProcess positive regulation of collateral sprouting of injured axon Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon. go.json activation of collateral sprouting of injured axon|stimulation of collateral sprouting of injured axon|up regulation of collateral sprouting of injured axon|up-regulation of collateral sprouting of injured axon|upregulation of collateral sprouting of injured axon http://purl.obolibrary.org/obo/GO_0048694 GO:0048693 biolink:BiologicalProcess regulation of collateral sprouting of injured axon Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon. go.json http://purl.obolibrary.org/obo/GO_0048693 GO:0048692 biolink:BiologicalProcess negative regulation of axon extension involved in regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration. go.json down regulation of axon extension involved in regeneration|down-regulation of axon extension involved in regeneration|downregulation of axon extension involved in regeneration|inhibition of axon extension involved in regeneration http://purl.obolibrary.org/obo/GO_0048692 GO:0048691 biolink:BiologicalProcess positive regulation of axon extension involved in regeneration Any process that activates, maintains or increases the rate of axon extension involved in regeneration. go.json activation of axon extension involved in regeneration|stimulation of axon extension involved in regeneration|up regulation of axon extension involved in regeneration|up-regulation of axon extension involved in regeneration|upregulation of axon extension involved in regeneration http://purl.obolibrary.org/obo/GO_0048691 GO:1903859 biolink:BiologicalProcess regulation of dendrite extension Any process that modulates the frequency, rate or extent of dendrite extension. go.json http://purl.obolibrary.org/obo/GO_1903859 GO:0048690 biolink:BiologicalProcess regulation of axon extension involved in regeneration Any process that modulates the frequency, rate or extent of axon extension involved in regeneration. go.json http://purl.obolibrary.org/obo/GO_0048690 GO:1903858 biolink:BiologicalProcess protein localization to old growing cell tip A process in which a protein is transported to, or maintained in, a location within an old growing cell tip. go.json protein localisation in old growing cell tip|protein localisation to old growing cell tip|protein localization in old growing cell tip http://purl.obolibrary.org/obo/GO_1903858 GO:1903857 biolink:BiologicalProcess negative regulation of cytokinin dehydrogenase activity Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity. go.json down regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity|down regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity|down regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity|down regulation of cytokinin dehydrogenase activity|down regulation of cytokinin oxidase activity|down-regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity|down-regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity|down-regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity|down-regulation of cytokinin dehydrogenase activity|down-regulation of cytokinin oxidase activity|downregulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity|downregulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity|downregulation of N6-dimethylallyladenine:acceptor oxidoreductase activity|downregulation of cytokinin dehydrogenase activity|downregulation of cytokinin oxidase activity|inhibition of 6-N-dimethylallyladenine:acceptor oxidoreductase activity|inhibition of N6-dimethylallyladenine:(acceptor) oxidoreductase activity|inhibition of N6-dimethylallyladenine:acceptor oxidoreductase activity|inhibition of cytokinin dehydrogenase activity|inhibition of cytokinin oxidase activity|negative regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity|negative regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity|negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity|negative regulation of cytokinin oxidase activity http://purl.obolibrary.org/obo/GO_1903857 gocheck_do_not_annotate GO:1903856 biolink:BiologicalProcess regulation of cytokinin dehydrogenase activity Any process that modulates the frequency, rate or extent of cytokinin dehydrogenase activity. go.json regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity|regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity|regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity|regulation of cytokinin oxidase activity http://purl.obolibrary.org/obo/GO_1903856 gocheck_do_not_annotate GO:1903855 biolink:BiologicalProcess positive regulation of stress response to copper ion Any process that activates or increases the frequency, rate or extent of stress response to copper ion. go.json activation of response to copper ion stress|activation of response to copper toxicity|activation of stress response to copper ion|positive regulation of response to copper ion stress|positive regulation of response to copper toxicity|up regulation of response to copper ion stress|up regulation of response to copper toxicity|up regulation of stress response to copper ion|up-regulation of response to copper ion stress|up-regulation of response to copper toxicity|up-regulation of stress response to copper ion|upregulation of response to copper ion stress|upregulation of response to copper toxicity|upregulation of stress response to copper ion http://purl.obolibrary.org/obo/GO_1903855 GO:1903854 biolink:BiologicalProcess negative regulation of stress response to copper ion Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion. go.json down regulation of response to copper ion stress|down regulation of response to copper toxicity|down regulation of stress response to copper ion|down-regulation of response to copper ion stress|down-regulation of response to copper toxicity|down-regulation of stress response to copper ion|downregulation of response to copper ion stress|downregulation of response to copper toxicity|downregulation of stress response to copper ion|inhibition of response to copper ion stress|inhibition of response to copper toxicity|inhibition of stress response to copper ion|negative regulation of response to copper ion stress|negative regulation of response to copper toxicity http://purl.obolibrary.org/obo/GO_1903854 GO:1903853 biolink:BiologicalProcess regulation of stress response to copper ion Any process that modulates the frequency, rate or extent of stress response to copper ion. go.json regulation of response to copper ion stress|regulation of response to copper toxicity|regulation of stress response to copper http://purl.obolibrary.org/obo/GO_1903853 GO:0048699 biolink:BiologicalProcess generation of neurons The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. go.json neuron generation http://purl.obolibrary.org/obo/GO_0048699 GO:1903852 biolink:BiologicalProcess positive regulation of cristae formation Any process that activates or increases the frequency, rate or extent of cristae formation. go.json activation of cristae formation|up regulation of cristae formation|up-regulation of cristae formation|upregulation of cristae formation http://purl.obolibrary.org/obo/GO_1903852 GO:1903851 biolink:BiologicalProcess negative regulation of cristae formation Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation. go.json down regulation of cristae formation|down-regulation of cristae formation|downregulation of cristae formation|inhibition of cristae formation http://purl.obolibrary.org/obo/GO_1903851 GO:0048698 biolink:BiologicalProcess negative regulation of collateral sprouting in absence of injury Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury. go.json down regulation of collateral sprouting in the absence of injury|down-regulation of collateral sprouting in the absence of injury|downregulation of collateral sprouting in the absence of injury|inhibition of collateral sprouting in the absence of injury http://purl.obolibrary.org/obo/GO_0048698 GO:0048697 biolink:BiologicalProcess positive regulation of collateral sprouting in absence of injury Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury. go.json activation of collateral sprouting in the absence of injury|stimulation of collateral sprouting in the absence of injury|up regulation of collateral sprouting in the absence of injury|up-regulation of collateral sprouting in the absence of injury|upregulation of collateral sprouting in the absence of injury http://purl.obolibrary.org/obo/GO_0048697 GO:1903850 biolink:BiologicalProcess regulation of cristae formation Any process that modulates the frequency, rate or extent of cristae formation. go.json http://purl.obolibrary.org/obo/GO_1903850 GO:0048696 biolink:BiologicalProcess regulation of collateral sprouting in absence of injury Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury. go.json http://purl.obolibrary.org/obo/GO_0048696 GO:0034065 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0034065 GO:0034064 biolink:CellularComponent Tor2-Mei2-Ste11 complex A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast. go.json http://purl.obolibrary.org/obo/GO_0034064 GO:0034063 biolink:BiologicalProcess stress granule assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. go.json SG assembly http://purl.obolibrary.org/obo/GO_0034063 GO:0034062 biolink:MolecularActivity 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end. RHEA:21248|Reactome:R-HSA-5696807|Reactome:R-HSA-6786881 go.json C RNA formation factors|C ribonucleic acid formation factors|RNA nucleotidyltransferase activity|RNA polymerase activity|RNA transcriptase activity|ribonucleate nucleotidyltransferase activity|ribonucleate polymerase activity|ribonucleic acid nucleotidyltransferase|ribonucleic acid polymerase activity|ribonucleic acid transcriptase activity|ribonucleic polymerase activity|ribonucleic transcriptase activity|transcriptase http://purl.obolibrary.org/obo/GO_0034062 GO:0034061 biolink:MolecularActivity DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. go.json DNA nucleotidyltransferase activity|deoxynucleate polymerase activity|deoxyribonucleate nucleotidyltransferase activity|deoxyribonucleic acid polymerase activity|deoxyribonucleic polymerase activity http://purl.obolibrary.org/obo/GO_0034061 GO:0034060 biolink:CellularComponent cyanelle stroma The space enclosed by the double membrane of a cyanelle. go.json http://purl.obolibrary.org/obo/GO_0034060 GO:0034069 biolink:MolecularActivity aminoglycoside N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside. go.json kanamycin acetyltransferase activity http://purl.obolibrary.org/obo/GO_0034069 GO:0034068 biolink:MolecularActivity aminoglycoside nucleotidyltransferase activity Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside. go.json aminoglycoside adenylyltransferase activity|streptomycin adenylate synthetase activity|streptomycin adenyltransferase activity|streptomycin adenylylase activity|streptomycin adenylyltransferase activity|streptomycin-spectinomycin adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0034068 GO:0034067 biolink:BiologicalProcess protein localization to Golgi apparatus A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. go.json establishment of protein localisation to Golgi|establishment of protein localization in Golgi|establishment of protein localization to Golgi|establishment of protein localization to Golgi apparatus|protein localisation in Golgi apparatus|protein localization in Golgi apparatus|protein targeting to Golgi|protein-Golgi targeting http://purl.obolibrary.org/obo/GO_0034067 GO:0034066 biolink:CellularComponent Ric1-Rgp1 guanyl-nucleotide exchange factor complex A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi. go.json Ric1p-Rgp1p complex http://purl.obolibrary.org/obo/GO_0034066 GO:0102870 biolink:MolecularActivity 7-hydroxyflavone-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone = 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+. MetaCyc:RXN-8355 go.json http://purl.obolibrary.org/obo/GO_0102870 GO:0102872 biolink:MolecularActivity 1-16:0-2-18:2-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor = 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. EC:1.14.19.25|MetaCyc:RXN-8361 go.json http://purl.obolibrary.org/obo/GO_0102872 GO:0102871 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102871 GO:0102874 biolink:MolecularActivity 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8365 go.json http://purl.obolibrary.org/obo/GO_0102874 GO:0102873 biolink:MolecularActivity 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8363 go.json http://purl.obolibrary.org/obo/GO_0102873 GO:0102876 biolink:MolecularActivity psoralen synthase activity Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 = psoralen + NADP + acetone + 2 H2O. EC:1.14.14.141|MetaCyc:RXN-8386|RHEA:19281 go.json http://purl.obolibrary.org/obo/GO_0102876 GO:0102875 biolink:MolecularActivity 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8366 go.json http://purl.obolibrary.org/obo/GO_0102875 GO:0102878 biolink:MolecularActivity (+)-alpha-barbatene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-alpha-barbatene + diphosphoric acid. EC:4.2.3.69|MetaCyc:RXN-8417|RHEA:29499 go.json http://purl.obolibrary.org/obo/GO_0102878 GO:0102877 biolink:MolecularActivity alpha-copaene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-copaene + diphosphoric acid. EC:4.2.3.133|MetaCyc:RXN-8416|RHEA:33991 go.json http://purl.obolibrary.org/obo/GO_0102877 GO:0102879 biolink:MolecularActivity (+)-thujopsene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-thujopsene + diphosphoric acid. EC:4.2.3.79|MetaCyc:RXN-8418|RHEA:30375 go.json http://purl.obolibrary.org/obo/GO_0102879 GO:0102881 biolink:MolecularActivity (+)-beta-barbatene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-beta-barbatene + diphosphoric acid. MetaCyc:RXN-8421 go.json http://purl.obolibrary.org/obo/GO_0102881 GO:0102880 biolink:MolecularActivity isobazzanene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = isobazzanene + diphosphoric acid. MetaCyc:RXN-8419 go.json http://purl.obolibrary.org/obo/GO_0102880 GO:0102883 biolink:MolecularActivity (+)-beta-chamigrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-beta-chamigrene + diphosphoric acid. EC:4.2.3.78|MetaCyc:RXN-8424|RHEA:30379 go.json http://purl.obolibrary.org/obo/GO_0102883 GO:0102882 biolink:MolecularActivity beta-acoradiene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-acoradiene + diphosphoric acid. MetaCyc:RXN-8423 go.json http://purl.obolibrary.org/obo/GO_0102882 GO:0102885 biolink:MolecularActivity alpha-cuprenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphoric acid. EC:4.2.3.95|MetaCyc:RXN-8426|RHEA:32027 go.json http://purl.obolibrary.org/obo/GO_0102885 GO:0102884 biolink:MolecularActivity alpha-zingiberene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = zingiberene + diphosphoric acid. EC:4.2.3.65|MetaCyc:RXN-8425|RHEA:28643 go.json http://purl.obolibrary.org/obo/GO_0102884 GO:0102887 biolink:MolecularActivity beta-sesquiphellandrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-sesquiphellandrene + diphosphoric acid. EC:4.2.3.123|MetaCyc:RXN-8430|RHEA:32699 go.json http://purl.obolibrary.org/obo/GO_0102887 GO:0102886 biolink:MolecularActivity alpha-chamigrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-chamigrene + diphosphoric acid. MetaCyc:RXN-8428 go.json http://purl.obolibrary.org/obo/GO_0102886 GO:0102889 biolink:MolecularActivity beta-elemene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-elemene + diphosphoric acid. MetaCyc:RXN-8432 go.json http://purl.obolibrary.org/obo/GO_0102889 GO:0102888 biolink:MolecularActivity delta-cuprenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = delta-cuprenene + diphosphoric acid. MetaCyc:RXN-8431 go.json http://purl.obolibrary.org/obo/GO_0102888 GO:0102890 biolink:MolecularActivity naringenin chalcone 4'-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+. EC:2.4.1.286|MetaCyc:RXN-8453|RHEA:34291 go.json http://purl.obolibrary.org/obo/GO_0102890 GO:0102892 biolink:MolecularActivity betanidin 5-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + betanidin = H+ + betanin + UDP. MetaCyc:RXN-8479 go.json http://purl.obolibrary.org/obo/GO_0102892 GO:0102891 biolink:MolecularActivity 2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone = H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP. EC:2.4.1.286|MetaCyc:RXN-8455|RHEA:34295 go.json http://purl.obolibrary.org/obo/GO_0102891 GO:0102894 biolink:MolecularActivity UDPG:cyclo-DOPA 5-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome = H+ + cyclo-dopa 5-O-glucoside + UDP. MetaCyc:RXN-8481 go.json http://purl.obolibrary.org/obo/GO_0102894 GO:0102893 biolink:MolecularActivity betanidin 6-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + betanidin = H+ + gomphrenin I + UDP. MetaCyc:RXN-8480 go.json http://purl.obolibrary.org/obo/GO_0102893 GO:0102896 biolink:MolecularActivity colnelenate synthase activity Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate = colnelenate + H2O. MetaCyc:RXN-8498|RHEA:28178 go.json http://purl.obolibrary.org/obo/GO_0102896 GO:0102895 biolink:MolecularActivity colneleate synthase activity Catalysis of the reaction: 9(S)-HPODE = colneleate + H2O. EC:4.2.1.121|MetaCyc:RXN-8496|RHEA:28174 go.json http://purl.obolibrary.org/obo/GO_0102895 GO:0102898 biolink:MolecularActivity levopimaradienol hydroxylase activity Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 = levopiramadiene-diol + NADP + H2O. MetaCyc:RXN-8517 go.json http://purl.obolibrary.org/obo/GO_0102898 GO:0102897 biolink:MolecularActivity abietadienal hydroxylase activity Catalysis of the reaction: abietal + NADPH + O2 = abietate + NADP + H2O. MetaCyc:RXN-8510|RHEA:56928 go.json http://purl.obolibrary.org/obo/GO_0102897 GO:0102899 biolink:MolecularActivity dehydroabietadienol hydroxylase activity Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 = dehydroabietadiene-diol + NADP + H2O. MetaCyc:RXN-8532 go.json http://purl.obolibrary.org/obo/GO_0102899 GO:0102830 biolink:MolecularActivity verbascose synthase activity Catalysis of the reaction: 2 stachyose = verbascose + raffinose. MetaCyc:RXN-8286 go.json http://purl.obolibrary.org/obo/GO_0102830 GO:0102832 biolink:MolecularActivity verbascose galactinol:ajugose galactosyltransferase activity Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = ajugose + myo-inositol. MetaCyc:RXN-8288 go.json http://purl.obolibrary.org/obo/GO_0102832 GO:0102831 biolink:MolecularActivity stachyose synthase activity Catalysis of the reaction: 2 raffinose = stachyose + sucrose. MetaCyc:RXN-8287 go.json http://purl.obolibrary.org/obo/GO_0102831 GO:0102834 biolink:MolecularActivity 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8294 go.json http://purl.obolibrary.org/obo/GO_0102834 GO:0102833 biolink:MolecularActivity sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol = D-galactosylononitol + myo-inositol. MetaCyc:RXN-8292 go.json http://purl.obolibrary.org/obo/GO_0102833 GO:0102836 biolink:MolecularActivity 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8296 go.json http://purl.obolibrary.org/obo/GO_0102836 GO:0102835 biolink:MolecularActivity 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8295 go.json http://purl.obolibrary.org/obo/GO_0102835 GO:0102838 biolink:MolecularActivity 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8298 go.json http://purl.obolibrary.org/obo/GO_0102838 GO:0102837 biolink:MolecularActivity 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8297 go.json http://purl.obolibrary.org/obo/GO_0102837 GO:0102839 biolink:MolecularActivity 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8299 go.json http://purl.obolibrary.org/obo/GO_0102839 GO:0102841 biolink:MolecularActivity 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8302 go.json http://purl.obolibrary.org/obo/GO_0102841 GO:0102840 biolink:MolecularActivity 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8301 go.json http://purl.obolibrary.org/obo/GO_0102840 GO:0102843 biolink:MolecularActivity 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming) Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.42|MetaCyc:RXN-8304|RHEA:46756 go.json http://purl.obolibrary.org/obo/GO_0102843 GO:0102842 biolink:MolecularActivity 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming) Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8303|RHEA:46412 go.json http://purl.obolibrary.org/obo/GO_0102842 GO:0102845 biolink:MolecularActivity 1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8307 go.json http://purl.obolibrary.org/obo/GO_0102845 GO:0102844 biolink:MolecularActivity 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming) Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8305 go.json http://purl.obolibrary.org/obo/GO_0102844 GO:0102847 biolink:MolecularActivity 1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8309 go.json http://purl.obolibrary.org/obo/GO_0102847 GO:0102846 biolink:MolecularActivity 1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8308 go.json http://purl.obolibrary.org/obo/GO_0102846 GO:0102849 biolink:MolecularActivity 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8314 go.json http://purl.obolibrary.org/obo/GO_0102849 GO:0102848 biolink:MolecularActivity 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.35|MetaCyc:RXN-8310 go.json http://purl.obolibrary.org/obo/GO_0102848 GO:0004385 biolink:MolecularActivity guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP. EC:2.7.4.8|MetaCyc:GUANYL-KIN-RXN|RHEA:20780|Reactome:R-HSA-110133|Reactome:R-HSA-73788|Reactome:R-HSA-9748949|Reactome:R-HSA-9748963 go.json 5'-GMP kinase activity|ATP:(d)GMP phosphotransferase activity|ATP:GMP phosphotransferase activity|GMP kinase activity|deoxyguanylate kinase activity|guanosine monophosphate kinase activity|membrane-associated guanylate kinase http://purl.obolibrary.org/obo/GO_0004385 GO:0102850 biolink:MolecularActivity 1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor = 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-8316|RHEA:46376 go.json http://purl.obolibrary.org/obo/GO_0102850 GO:0004384 biolink:MolecularActivity obsolete membrane-associated guanylate kinase OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane. go.json MAGUK|membrane-associated guanylate kinase True http://purl.obolibrary.org/obo/GO_0004384 GO:0102852 biolink:MolecularActivity 1-18:3-2-16:0-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8319 go.json http://purl.obolibrary.org/obo/GO_0102852 GO:0102851 biolink:MolecularActivity 1-18:2-2-16:0-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.43|MetaCyc:RXN-8318 go.json http://purl.obolibrary.org/obo/GO_0102851 GO:0004386 biolink:MolecularActivity helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. Reactome:R-HSA-169461|Reactome:R-HSA-169468|Reactome:R-HSA-5686410|Reactome:R-HSA-5690996 go.json ATP-dependent helicase activity http://purl.obolibrary.org/obo/GO_0004386 goslim_candida|goslim_chembl|goslim_pir|goslim_yeast GO:0004381 biolink:MolecularActivity fucosylgalactoside 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. EC:2.4.1.37|MetaCyc:2.4.1.37-RXN|RHEA:14349|Reactome:R-HSA-9033961|Reactome:R-HSA-9034053 go.json B transferase activity|UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity|UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity|UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity|[blood group substance] alpha-galactosyltransferase activity|blood-group substance B-dependent galactosyltransferase activity|blood-group substance beta-dependent galactosyltransferase activity|fucosylglycoprotein 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity|histo-blood group B transferase activity|histo-blood substance B-dependent galactosyltransferase activity|histo-blood substance beta-dependent galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0004381 GO:0102854 biolink:MolecularActivity 1-18:2-2-18:1-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8321 go.json http://purl.obolibrary.org/obo/GO_0102854 GO:0004380 biolink:MolecularActivity glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. EC:2.4.1.40|MetaCyc:2.4.1.40-RXN|RHEA:19021|Reactome:R-HSA-9033959|Reactome:R-HSA-9034042 go.json A transferase activity|A-transferase activity|UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity|alpha-3-N-acetylgalactosaminyltransferase activity|blood-group substance A-dependent acetylgalactosaminyltransferase activity|blood-group substance alpha-acetyltransferase activity|fucosylgalactose acetylgalactosaminyltransferase activity|fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity|fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity|histo-blood group A acetylgalactosaminyltransferase activity|histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)|histo-blood group A transferase activity http://purl.obolibrary.org/obo/GO_0004380 GO:0102853 biolink:MolecularActivity 1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8320 go.json http://purl.obolibrary.org/obo/GO_0102853 GO:0102856 biolink:MolecularActivity 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. EC:1.14.19.25|MetaCyc:RXN-8323 go.json http://purl.obolibrary.org/obo/GO_0102856 GO:0004383 biolink:MolecularActivity guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. EC:4.6.1.2|MetaCyc:GUANYLCYC-RXN|RHEA:13665|Reactome:R-HSA-392152|Reactome:R-HSA-74885 go.json GTP diphosphate-lyase (cyclizing) activity|GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity|guanyl cyclase activity|guanylyl cyclase activity|receptor guanylate cyclase activity http://purl.obolibrary.org/obo/GO_0004383 GO:0102855 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102855 GO:0004382 biolink:MolecularActivity GDP phosphatase activity Catalysis of the reaction: GDP + H2O = GMP + phosphate. EC:3.6.1.42|MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN|RHEA:22156 go.json GDP diphosphatase activity|GDP phosphohydrolase activity|GDPase activity|guanosine 5'-diphosphatase activity|guanosine diphosphatase activity|guanosine-diphosphatase activity http://purl.obolibrary.org/obo/GO_0004382 GO:0102858 biolink:MolecularActivity 1-18:2-2-18:3-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8325 go.json http://purl.obolibrary.org/obo/GO_0102858 GO:0102857 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102857 GO:0102859 biolink:MolecularActivity 1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming) Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. EC:1.14.19.25|MetaCyc:RXN-8326|RHEA:46404 go.json http://purl.obolibrary.org/obo/GO_0102859 GO:0004399 biolink:MolecularActivity histidinol dehydrogenase activity Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. EC:1.1.1.23|MetaCyc:HISTALDEHYD-RXN|MetaCyc:HISTOLDEHYD-RXN|RHEA:20641 go.json http://purl.obolibrary.org/obo/GO_0004399 GO:0004396 biolink:MolecularActivity hexokinase activity Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. EC:2.7.1.1|MetaCyc:HEXOKINASE-RXN|RHEA:22740 go.json ATP-dependent hexokinase activity|ATP:D-hexose 6-phosphotransferase activity|glucose ATP phosphotransferase activity|hexokinase (phosphorylating)|hexokinase D|hexokinase type I activity|hexokinase type II activity|hexokinase type III activity|hexokinase type IV|hexokinase type IV (glucokinase) activity|hexokinase type IV glucokinase activity http://purl.obolibrary.org/obo/GO_0004396 GO:0102861 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102861 GO:0004395 biolink:MolecularActivity hexaprenyldihydroxybenzoate methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. EC:2.1.1.114|MetaCyc:RXN-20172|RHEA:14121 go.json 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity|DHHB methyltransferase activity|DHHB-Mt activity|S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity|dihydroxyhexaprenylbenzoate methyltransferase activity http://purl.obolibrary.org/obo/GO_0004395 GO:0102860 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102860 GO:0004398 biolink:MolecularActivity histidine decarboxylase activity Catalysis of the reaction: L-histidine = histamine + CO2. EC:4.1.1.22|MetaCyc:HISTIDINE-DECARBOXYLASE-RXN|RHEA:20840|Reactome:R-HSA-977301 go.json L-histidine carboxy-lyase (histamine-forming)|L-histidine carboxy-lyase activity|L-histidine decarboxylase activity http://purl.obolibrary.org/obo/GO_0004398 GO:0102863 biolink:MolecularActivity 1-18:3-2-18:1-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8330 go.json http://purl.obolibrary.org/obo/GO_0102863 GO:0004397 biolink:MolecularActivity histidine ammonia-lyase activity Catalysis of the reaction: L-histidine = urocanate + NH3. EC:4.3.1.3|MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN|RHEA:21232|Reactome:R-HSA-70899 go.json L-histidine ammonia-lyase (urocanate-forming)|L-histidine ammonia-lyase activity|histidase activity|histidinase activity|histidine alpha-deaminase activity http://purl.obolibrary.org/obo/GO_0004397 GO:0102862 biolink:MolecularActivity 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming) Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. EC:1.14.19.25|MetaCyc:RXN-8329 go.json http://purl.obolibrary.org/obo/GO_0102862 GO:0004392 biolink:MolecularActivity heme oxygenase (decyclizing) activity Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.18|MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN|RHEA:21764|Reactome:R-HSA-189398 go.json ORP33 proteins|haem oxidase activity|haem oxygenase (decyclizing) activity|haem oxygenase activity|heme oxidase activity|heme oxygenase activity|heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) http://purl.obolibrary.org/obo/GO_0004392 GO:0102865 biolink:MolecularActivity delta6-acyl-lipid desaturase activity Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O. EC:1.14.19.38|MetaCyc:RXN-8343|RHEA:46536 go.json http://purl.obolibrary.org/obo/GO_0102865 GO:0102864 biolink:MolecularActivity 1-18:3-2-18:2-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8331 go.json http://purl.obolibrary.org/obo/GO_0102864 GO:0102867 biolink:MolecularActivity molybdenum cofactor sulfurtransferase activity Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine = thio-molybdenum cofactor + L-alanine + H2O. EC:2.8.1.9|MetaCyc:RXN-8351|RHEA:42636 go.json http://purl.obolibrary.org/obo/GO_0102867 GO:0004394 biolink:MolecularActivity heparan sulfate 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. Reactome:R-HSA-2076508 go.json heparan-sulfate 2-O-sulphotransferase activity|heparin 2-sulfotransferase activity|heparin-sulphate 2-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0004394 GO:0102866 biolink:MolecularActivity di-homo-gamma-linolenate delta5 desaturase activity Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor = arachidonate + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-8346|RHEA:46260 go.json http://purl.obolibrary.org/obo/GO_0102866 GO:0004393 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004393 GO:0102869 biolink:MolecularActivity 6-hydroxyflavone-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone = 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+. MetaCyc:RXN-8354 go.json http://purl.obolibrary.org/obo/GO_0102869 GO:0102868 biolink:MolecularActivity 24-epi-campsterol desaturase activity Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 = brassicasterol + NADP + 2 H2O. MetaCyc:RXN-8352 go.json http://purl.obolibrary.org/obo/GO_0102868 GO:0043971 biolink:BiologicalProcess histone H3-K18 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone. go.json histone H3 acetylation at K18|histone H3K18 acetylation http://purl.obolibrary.org/obo/GO_0043971 gocheck_do_not_annotate GO:0043970 biolink:BiologicalProcess histone H3-K9 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone. go.json histone H3 acetylation at K9|histone H3K9 acetylation http://purl.obolibrary.org/obo/GO_0043970 gocheck_do_not_annotate GO:0043973 biolink:BiologicalProcess histone H3-K4 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone. go.json histone H3 acetylation at K4|histone H3K4 acetylation http://purl.obolibrary.org/obo/GO_0043973 gocheck_do_not_annotate GO:0043972 biolink:BiologicalProcess histone H3-K23 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone. go.json histone H3 acetylation at K23|histone H3K23 acetylation http://purl.obolibrary.org/obo/GO_0043972 gocheck_do_not_annotate GO:0043979 biolink:BiologicalProcess histone H2B-K5 acetylation The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone. go.json histone H2B acetylation at K5 http://purl.obolibrary.org/obo/GO_0043979 gocheck_do_not_annotate GO:0043978 biolink:BiologicalProcess obsolete histone H2A-K9 acetylation OBSOLETE. The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone. go.json histone H2A acetylation at K9 True http://purl.obolibrary.org/obo/GO_0043978 GO:0043975 biolink:BiologicalProcess obsolete histone H3-K36 acetylation OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone. go.json histone H3 acetylation at K36|histone H3K36 acetylation True http://purl.obolibrary.org/obo/GO_0043975 GO:0043974 biolink:BiologicalProcess histone H3-K27 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone. go.json histone H3 acetylation at K27|histone H3K27 acetylation http://purl.obolibrary.org/obo/GO_0043974 gocheck_do_not_annotate GO:0043977 biolink:BiologicalProcess histone H2A-K5 acetylation The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone. go.json histone H2A acetylation at K5 http://purl.obolibrary.org/obo/GO_0043977 gocheck_do_not_annotate GO:0043976 biolink:BiologicalProcess obsolete histone H3-K79 acetylation OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone. go.json histone H3 acetylation at K79|histone H3K79 acetylation True http://purl.obolibrary.org/obo/GO_0043976 GO:0043982 biolink:BiologicalProcess histone H4-K8 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. go.json histone H4 acetylation at K8 http://purl.obolibrary.org/obo/GO_0043982 gocheck_do_not_annotate GO:0043981 biolink:BiologicalProcess histone H4-K5 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. go.json histone H4 acetylation at K5 http://purl.obolibrary.org/obo/GO_0043981 gocheck_do_not_annotate GO:0043984 biolink:BiologicalProcess histone H4-K16 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. go.json histone H4 acetylation at K16 http://purl.obolibrary.org/obo/GO_0043984 gocheck_do_not_annotate GO:0043983 biolink:BiologicalProcess histone H4-K12 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone. go.json histone H4 acetylation at K12 http://purl.obolibrary.org/obo/GO_0043983 gocheck_do_not_annotate GO:0043980 biolink:BiologicalProcess histone H2B-K12 acetylation The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone. go.json histone H2B acetylation at K12 http://purl.obolibrary.org/obo/GO_0043980 gocheck_do_not_annotate GO:0043989 biolink:BiologicalProcess obsolete histone H4-S1 phosphorylation OBSOLETE. The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone. go.json histone H4 phosphorylation at S1|histone H4S1 phosphorylation True http://purl.obolibrary.org/obo/GO_0043989 GO:0043986 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043986 GO:0043985 biolink:BiologicalProcess histone H4-R3 methylation The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone. go.json histone H4 R3 methylation|histone H4 methylation at R3|histone H4R3me http://purl.obolibrary.org/obo/GO_0043985 gocheck_do_not_annotate GO:0043988 biolink:BiologicalProcess obsolete histone H3-S28 phosphorylation OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone. go.json histone H3 phosphorylation at S28|histone H3S28 phosphorylation True http://purl.obolibrary.org/obo/GO_0043988 GO:0043987 biolink:BiologicalProcess obsolete histone H3-S10 phosphorylation OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone. go.json histone H3 phosphorylation at S10|histone H3S10 phosphorylation True http://purl.obolibrary.org/obo/GO_0043987 GO:0043993 biolink:MolecularActivity histone H3K18 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18). go.json histone H3-K18 acetyltransferase activity|histone acetylase activity (H3-K18 specific)|histone acetyltransferase activity (H3-K18 specific)|histone lysine N-acetyltransferase activity (H3-K18 specific) http://purl.obolibrary.org/obo/GO_0043993 GO:0043992 biolink:MolecularActivity histone H3K9 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9). go.json histone H3-K9 acetyltransferase activity|histone acetylase activity (H3-K9 specific)|histone acetyltransferase activity (H3-K9 specific)|histone lysine N-acetyltransferase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0043992 GO:0043995 biolink:MolecularActivity histone H4K5 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). go.json histone acetylase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K5 specific)|histone lysine N-acetyltransferase activity (H4-K5 specific) http://purl.obolibrary.org/obo/GO_0043995 GO:0043994 biolink:MolecularActivity histone H3K23 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23). go.json histone H3-K23 acetyltransferase activity|histone acetylase activity (H3-K23 specific)|histone acetyltransferase activity (H3-K23 specific)|histone lysine N-acetyltransferase activity (H3-K23 specific) http://purl.obolibrary.org/obo/GO_0043994 GO:0043991 biolink:BiologicalProcess obsolete histone H2B-S14 phosphorylation OBSOLETE. The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone. go.json histone H2B phosphorylation at S14|histone H2BS14 phosphorylation True http://purl.obolibrary.org/obo/GO_0043991 GO:0043990 biolink:BiologicalProcess obsolete histone H2A-S1 phosphorylation OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone. go.json histone H2A phosphorylation at S1|histone H2AS1 phosphorylation True http://purl.obolibrary.org/obo/GO_0043990 GO:0043997 biolink:MolecularActivity histone H4K12 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). go.json histone H4-K12 acetyltransferase activity|histone acetylase activity (H4-K12 specific)|histone acetyltransferase activity (H4-K12 specific)|histone lysine N-acetyltransferase activity (H4-K12 specific) http://purl.obolibrary.org/obo/GO_0043997 GO:0043996 biolink:MolecularActivity histone H4K8 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8). go.json histone acetylase activity (H4-K8 specific)|histone acetyltransferase activity (H4-K8 specific)|histone lysine N-acetyltransferase activity (H4-K8 specific) http://purl.obolibrary.org/obo/GO_0043996 GO:0043999 biolink:MolecularActivity histone H2AK5 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5). go.json histone H2A-K5 acetyltransferase activity|histone acetylase activity (H2A-K5 specific)|histone acetyltransferase activity (H2A-K5 specific)|histone lysine N-acetyltransferase activity (H2A-K5 specific) http://purl.obolibrary.org/obo/GO_0043999 GO:0043998 biolink:MolecularActivity histone H2A acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine. go.json H2A histone acetylase activity|H2A histone acetyltransferase activity|H2A histone lysine N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0043998 GO:0018928 biolink:BiologicalProcess methyl ethyl ketone metabolic process The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints. UM-BBD_pathwayID:mek go.json 2-butanone metabolic process|2-butanone metabolism|MEK metabolic process|MEK metabolism|methyl ethyl ketone metabolism http://purl.obolibrary.org/obo/GO_0018928 GO:0018927 biolink:BiologicalProcess obsolete methionine and threonine metabolic process OBSOLETE. (Was not defined before being made obsolete). go.json methionine and threonine metabolic process True http://purl.obolibrary.org/obo/GO_0018927 GO:0018929 biolink:BiologicalProcess methyl fluoride metabolic process The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils. UM-BBD_pathwayID:mf go.json methyl fluoride metabolism http://purl.obolibrary.org/obo/GO_0018929 GO:0018924 biolink:BiologicalProcess mandelate metabolic process The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. UM-BBD_pathwayID:mca go.json mandelate metabolism|mandelic acid metabolic process|mandelic acid metabolism http://purl.obolibrary.org/obo/GO_0018924 GO:0018923 biolink:BiologicalProcess limonene metabolic process The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. UM-BBD_pathwayID:lim go.json limonene metabolism http://purl.obolibrary.org/obo/GO_0018923 GO:0018926 biolink:BiologicalProcess methanesulfonic acid metabolic process The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide. UM-BBD_pathwayID:msa go.json methanesulfonic acid metabolism|methanesulphonic acid metabolic process|methanesulphonic acid metabolism http://purl.obolibrary.org/obo/GO_0018926 GO:0018925 biolink:BiologicalProcess m-cresol metabolic process The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes. MetaCyc:M-CRESOL-DEGRADATION-PWY|UM-BBD_pathwayID:mcr go.json 3-hydroxytoluene metabolic process|3-hydroxytoluene metabolism|m-cresol metabolism|meta-cresol metabolic process|meta-cresol metabolism http://purl.obolibrary.org/obo/GO_0018925 GO:0018920 biolink:BiologicalProcess glyphosate metabolic process The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond. UM-BBD_pathwayID:gly go.json Roundup metabolic process|Roundup metabolism|glyphosate metabolism http://purl.obolibrary.org/obo/GO_0018920 GO:0018922 biolink:BiologicalProcess iprodione metabolic process The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium). UM-BBD_pathwayID:ipd go.json iprodione metabolism http://purl.obolibrary.org/obo/GO_0018922 GO:0018921 biolink:BiologicalProcess 3-hydroxybenzyl alcohol metabolic process The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum. UM-BBD_pathwayID:mcr go.json 3-hydroxybenzyl alcohol metabolism http://purl.obolibrary.org/obo/GO_0018921 GO:0018939 biolink:BiologicalProcess n-octane metabolic process The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System. UM-BBD_pathwayID:oct go.json n-octane metabolism http://purl.obolibrary.org/obo/GO_0018939 GO:0018938 biolink:BiologicalProcess 2-nitropropane metabolic process The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol. MetaCyc:PWY-723|UM-BBD_pathwayID:npp go.json 2-nitropropane metabolism http://purl.obolibrary.org/obo/GO_0018938 GO:0018935 biolink:BiologicalProcess aerobic nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen. go.json aerobic nitrilotriacetate metabolism http://purl.obolibrary.org/obo/GO_0018935 GO:0043902 biolink:BiologicalProcess obsolete positive regulation of multi-organism process OBSOLETE. Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. go.json True http://purl.obolibrary.org/obo/GO_0043902 GO:0043901 biolink:BiologicalProcess obsolete negative regulation of multi-organism process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. go.json True http://purl.obolibrary.org/obo/GO_0043901 GO:0018934 biolink:BiologicalProcess nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment. UM-BBD_pathwayID:nta go.json nitrilotriacetate metabolism http://purl.obolibrary.org/obo/GO_0018934 GO:0018937 biolink:BiologicalProcess nitroglycerin metabolic process The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates. MetaCyc:P201-PWY|UM-BBD_pathwayID:ng go.json NG metabolic process|NG metabolism|nitroglycerin metabolism http://purl.obolibrary.org/obo/GO_0018937 GO:0043904 biolink:MolecularActivity isochorismate pyruvate lyase activity Catalysis of the reaction: isochorismate = salicylate + pyruvate. EC:4.2.99.21|MetaCyc:RXN-1981|RHEA:27874 go.json IPL|isochorismate-pyruvate lyase activity http://purl.obolibrary.org/obo/GO_0043904 GO:0018936 biolink:BiologicalProcess anaerobic nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen. go.json anaerobic nitrilotriacetate metabolism http://purl.obolibrary.org/obo/GO_0018936 GO:0043903 biolink:BiologicalProcess regulation of biological process involved in symbiotic interaction Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. go.json regulation of interspecies interactions between organisms|regulation of symbiosis, encompassing mutualism through parasitism|regulation of symbiotic process http://purl.obolibrary.org/obo/GO_0043903 GO:0018931 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018931 GO:0018930 biolink:BiologicalProcess 3-methylquinoline metabolic process The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. UM-BBD_pathwayID:mqn go.json 3-methylquinoline metabolism http://purl.obolibrary.org/obo/GO_0018930 GO:0018933 biolink:BiologicalProcess nicotine metabolic process The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. go.json nicotine metabolism http://purl.obolibrary.org/obo/GO_0018933 GO:0043900 biolink:BiologicalProcess obsolete regulation of multi-organism process OBSOLETE. Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. go.json True http://purl.obolibrary.org/obo/GO_0043900 GO:0018932 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018932 GO:0043909 biolink:MolecularActivity N-acetylcitrulline deacetylase activity Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate. RHEA:61092 go.json N-acetyl-L-citrulline deacetylase activity|acetylcitrulline deacetylase activity http://purl.obolibrary.org/obo/GO_0043909 GO:0043906 biolink:MolecularActivity Ala-tRNA(Pro) hydrolase activity Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro). go.json Ala-tRNAPro hydrolase activity http://purl.obolibrary.org/obo/GO_0043906 GO:0043905 biolink:MolecularActivity L-seryl-tRNA(Thr) hydrolase activity Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr). go.json Ser-tRNA(Thr) hydrolase activity|Ser-tRNAThr hydrolase activity http://purl.obolibrary.org/obo/GO_0043905 GO:0043908 biolink:MolecularActivity Ser(Gly)-tRNA(Ala) hydrolase activity Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala). go.json Ser(Gly)-tRNAAla hydrolase activity http://purl.obolibrary.org/obo/GO_0043908 GO:0043907 biolink:MolecularActivity Cys-tRNA(Pro) hydrolase activity Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro). go.json Cys-tRNA(Pro) deacetylase activity|Cys-tRNAPro hydrolase activity http://purl.obolibrary.org/obo/GO_0043907 GO:0018909 biolink:BiologicalProcess dodecyl sulfate metabolic process The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants. UM-BBD_pathwayID:dds go.json dodecyl sulfate metabolism|dodecyl sulphate metabolic process|dodecyl sulphate metabolism http://purl.obolibrary.org/obo/GO_0018909 GO:0018906 biolink:BiologicalProcess methyl tert-butyl ether metabolic process The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent. UM-BBD_pathwayID:mtb go.json methyl tert-butyl ether metabolism http://purl.obolibrary.org/obo/GO_0018906 GO:0018905 biolink:BiologicalProcess dimethyl ether metabolic process The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications. UM-BBD_pathwayID:dme go.json dimethyl ether metabolism|methyl ether metabolic process|methyl ether metabolism http://purl.obolibrary.org/obo/GO_0018905 GO:0018908 biolink:BiologicalProcess organosulfide cycle A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle. UM-BBD_pathwayID:sulf go.json organosulphide cycle http://purl.obolibrary.org/obo/GO_0018908 GO:0018907 biolink:BiologicalProcess dimethyl sulfoxide metabolic process The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing. UM-BBD_pathwayID:sulf go.json DMSO metabolic process|DMSO metabolism|dimethyl sulfoxide metabolism|dimethyl sulphoxide metabolic process|dimethyl sulphoxide metabolism http://purl.obolibrary.org/obo/GO_0018907 GO:0043913 biolink:CellularComponent obsolete chromosome segregation-directing complex OBSOLETE. A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology. go.json MreBCD complex|chromosome segregation directing complex|longitudinal peptidoglycan synthesis-directing complex True http://purl.obolibrary.org/obo/GO_0043913 GO:0018902 biolink:BiologicalProcess obsolete 1,3-dichloro-2-propanol metabolic process OBSOLETE. The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers. UM-BBD_pathwayID:dcp go.json 1,3-dichloro-2-propanol metabolism|DCP metabolic process|DCP metabolism True http://purl.obolibrary.org/obo/GO_0018902 GO:0043912 biolink:MolecularActivity D-lysine oxidase activity Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide. EC:1.4.3.- go.json http://purl.obolibrary.org/obo/GO_0043912 GO:0018901 biolink:BiologicalProcess 2,4-dichlorophenoxyacetic acid metabolic process The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. UM-BBD_pathwayID:2,4-d go.json 2,4-D metabolic process|2,4-D metabolism|2,4-dichlorophenoxyacetic acid metabolism http://purl.obolibrary.org/obo/GO_0018901 GO:0018904 biolink:BiologicalProcess ether metabolic process The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. go.json ether metabolism|organic ether metabolic process|organic ether metabolism http://purl.obolibrary.org/obo/GO_0018904 goslim_pir GO:0043915 biolink:MolecularActivity L-seryl-tRNA(Sec) kinase activity Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec). EC:2.7.1.164|MetaCyc:RXN-10038|RHEA:25037 go.json O-phosphoseryl-tRNA(Sec) kinase activity http://purl.obolibrary.org/obo/GO_0043915 GO:0043914 biolink:MolecularActivity NADPH:sulfur oxidoreductase activity Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+. EC:1.8.1.18 go.json CoA-dependent NAD(P)H sulfur oxidoreductase activity|NAD(P)H elemental sulfur oxidoreductase activity|NAD(P)H sulfur oxidoreductase activity|NAD(P)H sulphur oxidoreductase activity|NAD(P)H:sulfur oxidoreductase activity|NADPH:sulphur oxidoreductase activity|NSR|coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043914 GO:0018903 biolink:BiologicalProcess 1,3-dichloropropene metabolic process The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes. UM-BBD_pathwayID:cpr go.json 1,3-dichloropropene metabolism|1,3-dichloropropylene metabolic process|1,3-dichloropropylene metabolism|gamma-chloroallylchloride metabolic process|gamma-chloroallylchloride metabolism http://purl.obolibrary.org/obo/GO_0018903 GO:0043911 biolink:MolecularActivity D-lysine transaminase activity Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate. go.json D-lysine aminotransferase activity http://purl.obolibrary.org/obo/GO_0043911 GO:0018900 biolink:BiologicalProcess dichloromethane metabolic process The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover. UM-BBD_pathwayID:dcm go.json dichloromethane metabolism http://purl.obolibrary.org/obo/GO_0018900 GO:0043910 biolink:MolecularActivity ATP:coenzyme F420 adenylyltransferase activity Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate. MetaCyc:RXN-9385 go.json ATP:coenzyme F420 adenyltransferase activity|coenzyme F390-A synthetase activity http://purl.obolibrary.org/obo/GO_0043910 GO:0043917 biolink:MolecularActivity ribose 1,5-bisphosphate isomerase activity Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate. EC:5.3.1.29|MetaCyc:RXN-8801|RHEA:32243 go.json ribose-1,5-bisphosphate isomerase activity http://purl.obolibrary.org/obo/GO_0043917 GO:0043916 biolink:MolecularActivity DNA-7-methylguanine glycosylase activity Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site. EC:3.2.2.21|MetaCyc:3.2.2.21-RXN go.json http://purl.obolibrary.org/obo/GO_0043916 GO:0043919 biolink:MolecularActivity agmatine aminopropyltransferase activity Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine. EC:2.5.1.104 go.json agmatine aminopropyl transferase activity http://purl.obolibrary.org/obo/GO_0043919 GO:0043918 biolink:MolecularActivity cadaverine aminopropyltransferase activity Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine. EC:2.5.1.104 go.json cadaverine aminopropyl transferase activity http://purl.obolibrary.org/obo/GO_0043918 GO:0018917 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018917 GO:0018916 biolink:BiologicalProcess nitrobenzene metabolic process The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline. UM-BBD_pathwayID:nb go.json nitrobenzene metabolism http://purl.obolibrary.org/obo/GO_0018916 GO:0018919 biolink:BiologicalProcess gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. MetaCyc:GAMMAHEXCHLORDEG-PWY|UM-BBD_pathwayID:ghch go.json gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism http://purl.obolibrary.org/obo/GO_0018919 GO:0018918 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018918 GO:0018913 biolink:BiologicalProcess anaerobic ethylbenzene metabolic process The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen. UM-BBD_pathwayID:ethb go.json anaerobic ethylbenzene metabolism http://purl.obolibrary.org/obo/GO_0018913 GO:0043924 biolink:MolecularActivity suramin binding Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms. go.json Germanin binding http://purl.obolibrary.org/obo/GO_0043924 GO:0043923 biolink:BiologicalProcess positive regulation by host of viral transcription Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. go.json positive regulation of viral transcription by host http://purl.obolibrary.org/obo/GO_0043923 GO:0018912 biolink:BiologicalProcess 1,4-dichlorobenzene metabolic process The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs. UM-BBD_pathwayID:dcz go.json 1,4-dichlorobenzene metabolism http://purl.obolibrary.org/obo/GO_0018912 GO:0043926 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043926 GO:0018915 biolink:BiologicalProcess ethylbenzene metabolic process The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels. UM-BBD_pathwayID:ethb2 go.json ethylbenzene metabolism http://purl.obolibrary.org/obo/GO_0018915 GO:0043925 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043925 GO:0018914 biolink:BiologicalProcess chlorobenzene metabolic process The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone. UM-BBD_pathwayID:cb go.json chlorobenzene metabolism http://purl.obolibrary.org/obo/GO_0018914 GO:0043920 biolink:MolecularActivity aminopropylagmatine ureohydrolase activity Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea. EC:3.5.3.24|RHEA:35827 go.json http://purl.obolibrary.org/obo/GO_0043920 GO:0018911 biolink:BiologicalProcess 1,2,4-trichlorobenzene metabolic process The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides. UM-BBD_pathwayID:tbz go.json 1,2,4-trichlorobenzene metabolism http://purl.obolibrary.org/obo/GO_0018911 GO:0043922 biolink:BiologicalProcess negative regulation by host of viral transcription Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. go.json negative regulation of viral transcription by host http://purl.obolibrary.org/obo/GO_0043922 GO:0018910 biolink:BiologicalProcess benzene metabolic process The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation. go.json benzene metabolism http://purl.obolibrary.org/obo/GO_0018910 GO:0043921 biolink:BiologicalProcess modulation by host of viral transcription Any process in which a host organism modulates the frequency, rate or extent of viral transcription. go.json regulation by host of viral transcription|regulation of viral transcription by host http://purl.obolibrary.org/obo/GO_0043921 GO:0043928 biolink:BiologicalProcess exonucleolytic catabolism of deadenylated mRNA The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. go.json http://purl.obolibrary.org/obo/GO_0043928 GO:0043927 biolink:BiologicalProcess obsolete exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap. go.json True http://purl.obolibrary.org/obo/GO_0043927 GO:0043929 biolink:BiologicalProcess primary ovarian follicle growth involved in double layer follicle stage Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis. go.json primary ovarian follicle growth during double layer follicle stage http://purl.obolibrary.org/obo/GO_0043929 GO:0043935 biolink:BiologicalProcess sexual sporulation resulting in formation of a cellular spore The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. go.json http://purl.obolibrary.org/obo/GO_0043935 GO:0043934 biolink:BiologicalProcess sporulation The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. Wikipedia:Spore go.json http://purl.obolibrary.org/obo/GO_0043934 goslim_metagenomics|goslim_yeast GO:0043937 biolink:BiologicalProcess regulation of sporulation Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0043937 GO:0043936 biolink:BiologicalProcess asexual sporulation resulting in formation of a cellular spore The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. go.json asexual reproduction resulting in the formation of a cellular spore|asexual sporulation resulting in the formation of a viable spore http://purl.obolibrary.org/obo/GO_0043936 GO:0043931 biolink:BiologicalProcess ossification involved in bone maturation The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. go.json ossification involved in bone modeling|ossification involved in skeletal development http://purl.obolibrary.org/obo/GO_0043931 GO:0043930 biolink:BiologicalProcess primary ovarian follicle growth involved in primary follicle stage Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis. go.json primary ovarian follicle growth during primary follicle stage http://purl.obolibrary.org/obo/GO_0043930 GO:0043933 biolink:BiologicalProcess protein-containing complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. go.json cellular macromolecular complex organization|cellular macromolecular complex subunit organisation|cellular macromolecular complex subunit organization|macromolecular complex organization|macromolecular complex subunit organisation|macromolecular complex subunit organization|protein complex subunit organisation|protein complex subunit organization|protein-containing complex subunit organization http://purl.obolibrary.org/obo/GO_0043933 GO:0043932 biolink:BiologicalProcess ossification involved in bone remodeling The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. go.json ossification involved in bone remodelling http://purl.obolibrary.org/obo/GO_0043932 GO:0043939 biolink:BiologicalProcess negative regulation of sporulation Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0043939 GO:0043938 biolink:BiologicalProcess positive regulation of sporulation Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0043938 GO:0043940 biolink:BiologicalProcess regulation of sexual sporulation resulting in formation of a cellular spore Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. go.json http://purl.obolibrary.org/obo/GO_0043940 GO:0043946 biolink:BiologicalProcess obsolete positive regulation of catalytic activity in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction. go.json activation of enzyme activity in other organism|activation of enzyme activity in other organism during symbiotic interaction|positive regulation of catalytic activity in other organism during symbiotic interaction|up regulation of enzyme activity in other organism during symbiotic interaction|up-regulation of enzyme activity in other organism during symbiotic interaction|upregulation of enzyme activity in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0043946 GO:0043945 biolink:BiologicalProcess positive regulation of asexual sporulation resulting in formation of a cellular spore Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis. go.json http://purl.obolibrary.org/obo/GO_0043945 GO:0043948 biolink:BiologicalProcess obsolete induction by symbiont of host catalytic activity OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host enzyme activity|activation of host enzyme activity|positive regulation by symbiont of host catalytic activity|positive regulation by symbiont of host enzyme activity|up regulation by symbiont of host enzyme activity|up-regulation by symbiont of host enzyme activity|upregulation by symbiont of host enzyme activity True http://purl.obolibrary.org/obo/GO_0043948 GO:0043947 biolink:BiologicalProcess obsolete positive regulation by host of symbiont catalytic activity OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of symbiont enzyme activity|activation of symbiont enzyme activity|positive regulation by host of symbiont enzyme activity|up regulation by host of symbiont enzyme activity|up-regulation by host of symbiont enzyme activity|upregulation by host of symbiont enzyme activity True http://purl.obolibrary.org/obo/GO_0043947 GO:0043942 biolink:BiologicalProcess negative regulation of sexual sporulation resulting in formation of a cellular spore Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. go.json http://purl.obolibrary.org/obo/GO_0043942 GO:0043941 biolink:BiologicalProcess positive regulation of sexual sporulation resulting in formation of a cellular spore Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. go.json http://purl.obolibrary.org/obo/GO_0043941 GO:0043944 biolink:BiologicalProcess negative regulation of asexual sporulation resulting in formation of a cellular spore Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis. go.json http://purl.obolibrary.org/obo/GO_0043944 GO:0043943 biolink:BiologicalProcess regulation of asexual sporulation resulting in formation of a cellular spore Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis. go.json http://purl.obolibrary.org/obo/GO_0043943 GO:0043949 biolink:BiologicalProcess regulation of cAMP-mediated signaling Any process which modulates the frequency, rate or extent of cAMP-mediated signaling. go.json regulation of cAMP-mediated signalling http://purl.obolibrary.org/obo/GO_0043949 GO:0043951 biolink:BiologicalProcess negative regulation of cAMP-mediated signaling Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling. go.json negative regulation of cAMP-mediated signalling http://purl.obolibrary.org/obo/GO_0043951 GO:0043950 biolink:BiologicalProcess positive regulation of cAMP-mediated signaling Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling. go.json positive regulation of cAMP-mediated signalling http://purl.obolibrary.org/obo/GO_0043950 GO:0043957 biolink:MolecularActivity acryloyl-CoA reductase (NADP+) activity Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+. EC:1.3.1.84|KEGG_REACTION:R00919|MetaCyc:RXN-9087|RHEA:26454 go.json AMP-dependent synthetase and ligase|AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase|acetyl-coenzyme A synthetase|acetyl-coenzyme A synthetase/GroES-like domain|acryloyl-CoA reductase (NADPH) activity|acrylyl-CoA reductase (NADPH) activity|enoyl-CoA hydratase/isomerase http://purl.obolibrary.org/obo/GO_0043957 GO:0043956 biolink:MolecularActivity 3-hydroxypropionyl-CoA dehydratase activity Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O. EC:4.2.1.116|MetaCyc:RXN-6383|RHEA:26518 go.json 3-hydroxy propionyl-CoA dehydratase activity|AMP-dependent synthetase and ligase|AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase|acetyl-coenzyme A synthetase|acetyl-coenzyme A synthetase/GroES-like domain|enoyl-CoA hydratase/isomerase http://purl.obolibrary.org/obo/GO_0043956 GO:0043959 biolink:MolecularActivity L-erythro-3-methylmalyl-CoA lyase activity Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA. EC:4.1.3.24 go.json HpcH/HpaI aldolase http://purl.obolibrary.org/obo/GO_0043959 GO:0043958 biolink:MolecularActivity acryloyl-CoA reductase (NADH) activity Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH. EC:1.3.1.95|MetaCyc:RXN-8568|RHEA:34471 go.json acryloyl-CoA reductase activity|acryloyl-coenzyme A reductase activity|acrylyl-CoA reductase (NADH)|propionyl-CoA dehydrogenase http://purl.obolibrary.org/obo/GO_0043958 GO:0043953 biolink:BiologicalProcess protein transport by the Tat complex The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. go.json protein secretion by the TAT complex|protein translocation by the TAT complex|protein translocation by the twin-arginine translocation complex|twin-arginine translocation pathway http://purl.obolibrary.org/obo/GO_0043953 GO:0043952 biolink:BiologicalProcess protein transport by the Sec complex The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide. go.json protein secretion by the Sec complex|protein translocation by the Sec complex http://purl.obolibrary.org/obo/GO_0043952 GO:0043955 biolink:MolecularActivity 3-hydroxypropionyl-CoA synthetase activity Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate. EC:6.2.1.36|RHEA:26534 go.json 3-hydroxy propionyl-CoA synthetase activity|AMP-dependent synthetase and ligase|AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase|acetyl-coenzyme A synthetase|acetyl-coenzyme A synthetase/GroES-like domain|enoyl-CoA hydratase/isomerase http://purl.obolibrary.org/obo/GO_0043955 GO:0043954 biolink:BiologicalProcess cellular component maintenance The organization process that preserves a cellular component in a stable functional or structural state. go.json cellular component maintenance at cellular level http://purl.obolibrary.org/obo/GO_0043954 GO:0043960 biolink:MolecularActivity L-erythro-3-methylmalyl-CoA dehydratase activity Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O. go.json http://purl.obolibrary.org/obo/GO_0043960 GO:0043962 biolink:BiologicalProcess obsolete negative regulation by host of symbiont adenylate cyclase-mediated signal transduction OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0043962 GO:0043961 biolink:MolecularActivity succinyl-CoA:(R)-citramalate CoA-transferase activity Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA. EC:2.8.3.20|MetaCyc:RXN-8966|RHEA:38279 go.json L-carnitine dehydratase/bile acid-inducible protein F|succinyl-CoA:(R)-citramalate CoA transferase activity|succinyl-CoA:R-citramalate CoA transferase http://purl.obolibrary.org/obo/GO_0043961 GO:0043968 biolink:BiologicalProcess histone H2A acetylation The modification of histone H2A by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0043968 gocheck_do_not_annotate GO:0043967 biolink:BiologicalProcess histone H4 acetylation The modification of histone H4 by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0043967 gocheck_do_not_annotate GO:0043969 biolink:BiologicalProcess histone H2B acetylation The modification of histone H2B by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0043969 gocheck_do_not_annotate GO:0043964 biolink:BiologicalProcess obsolete induction by symbiont of host adenylate cyclase-mediated signal transduction OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by symbiont of host adenylate cyclase-mediated signal transduction True http://purl.obolibrary.org/obo/GO_0043964 GO:0043963 biolink:BiologicalProcess perturbation of host adenylate cyclase-mediated signal transduction A process in which a symbiont alters or subverts an adenylate cyclase-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0043963 GO:0043966 biolink:BiologicalProcess histone H3 acetylation The modification of histone H3 by the addition of an acetyl group. go.json http://purl.obolibrary.org/obo/GO_0043966 gocheck_do_not_annotate GO:0043965 biolink:BiologicalProcess symbiont-mediated suppression of host adenylate cyclase-mediated signal transduction A process in which a virus interferes with, inhibits or disrupts an adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host adenylate cyclase-mediated signal transduction|negative regulation by symbiont of host adenylate cyclase-mediated signal transduction|suppression by symbiont of host adenylate cyclase-mediated signal transduction http://purl.obolibrary.org/obo/GO_0043965 GO:0004367 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004367 GO:0004366 biolink:MolecularActivity glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. EC:2.3.1.15|MetaCyc:RXN-1381|RHEA:15325|Reactome:R-HSA-1482695|Reactome:R-HSA-549112|Reactome:R-HSA-75886 go.json 3-glycerophosphate acyltransferase activity|ACP:sn-glycerol-3-phosphate acyltransferase activity|acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity|alpha-glycerophosphate acyltransferase activity|glycerol 3-phosphate acyltransferase activity|glycerol phosphate acyltransferase activity|glycerol phosphate transacylase activity|glycerophosphate acyltransferase activity|glycerophosphate transacylase activity|sn-glycerol 3-phosphate acyltransferase activity|sn-glycerol-3-phosphate acyltransferase activity http://purl.obolibrary.org/obo/GO_0004366 GO:0004369 biolink:MolecularActivity glycerol-3-phosphate oxidase activity Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2. EC:1.1.3.21|KEGG_REACTION:R00846|MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN|RHEA:18369 go.json L-alpha-glycerol-3-phosphate oxidase activity|L-alpha-glycerophosphate oxidase activity|alpha-glycerophosphate oxidase activity|glycerol phosphate oxidase activity|glycerol-1-phosphate oxidase activity|sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004369 GO:0004368 biolink:MolecularActivity glycerol-3-phosphate dehydrogenase (quinone) activity Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. EC:1.1.5.3|MetaCyc:RXN-15745|RHEA:18977|Reactome:R-HSA-188467 go.json FAD-dependent glycerol-3-phosphate dehydrogenase|L-glycerophosphate dehydrogenase activity|flavin-linked glycerol-3-phosphate dehydrogenase|glycerol-3-phosphate CoQ reductase|glycerophosphate dehydrogenase activity|sn-glycerol-3-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004368 GO:0004363 biolink:MolecularActivity glutathione synthase activity Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate. EC:6.3.2.3|KEGG_REACTION:R00497|MetaCyc:GLUTATHIONE-SYN-RXN|RHEA:13557|Reactome:R-HSA-174394|Reactome:R-HSA-5602901 go.json GSH synthetase activity|gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)|glutathione synthetase activity http://purl.obolibrary.org/obo/GO_0004363 GO:0004362 biolink:MolecularActivity glutathione-disulfide reductase (NADP) activity Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. EC:1.8.1.7|MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN|RHEA:11740|Reactome:R-HSA-3323079|Reactome:R-HSA-71682 go.json GSH reductase activity|GSSG reductase activity|NADPH-GSSG reductase activity|NADPH-glutathione reductase activity|NADPH:oxidized-glutathione oxidoreductase activity|glutathione S-reductase activity|glutathione reductase activity|glutathione-disulfide reductase activity|glutathione-disulphide reductase activity|glutathione:NADP+ oxidoreductase activity|oxidized glutathione reduction http://purl.obolibrary.org/obo/GO_0004362 GO:0004365 biolink:MolecularActivity glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. EC:1.2.1.12|MetaCyc:GAPOXNPHOSPHN-RXN|RHEA:10300|Reactome:R-HSA-70449|Reactome:R-HSA-70482 go.json 3-phosphoglyceraldehyde dehydrogenase activity|D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)|GAPDH activity|NAD-dependent glyceraldehyde phosphate dehydrogenase activity|NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity|NADH-glyceraldehyde phosphate dehydrogenase activity|dehydrogenase, glyceraldehyde phosphate|glyceraldehyde phosphate dehydrogenase (NAD)|glyceraldehyde-3-P-dehydrogenase activity|phosphoglyceraldehyde dehydrogenase activity|triosephosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004365 GO:0004364 biolink:MolecularActivity glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. EC:2.5.1.18|MetaCyc:GSHTRAN-RXN|Reactome:R-HSA-176054|Reactome:R-HSA-176059|Reactome:R-HSA-3301943|Reactome:R-HSA-5423653|Reactome:R-HSA-9026777|Reactome:R-HSA-9026780|Reactome:R-HSA-9026901|Reactome:R-HSA-9026911|Reactome:R-HSA-9748996|Reactome:R-HSA-9753280 go.json RX:glutathione R-transferase activity|S-(hydroxyalkyl)glutathione lyase activity|glutathione S-alkyl transferase activity|glutathione S-alkyltransferase activity|glutathione S-aralkyltransferase activity|glutathione S-aryltransferase activity|glutathione S-transferase activity|glutathione conjugation reaction http://purl.obolibrary.org/obo/GO_0004364 GO:0004361 biolink:MolecularActivity glutaryl-CoA dehydrogenase activity 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. EC:1.3.8.6|MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN|RHEA:13389|Reactome:R-HSA-71046|UM-BBD_reactionID:r0198 go.json glutaryl coenzyme A dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004361 GO:0102911 biolink:MolecularActivity (-)-secoisolariciresinol dehydrogenase activity Catalysis of the reaction: (-)-secoisolariciresinol + NAD = H+ + (-)-lactol + NADH. MetaCyc:RXN-8680 go.json http://purl.obolibrary.org/obo/GO_0102911 GO:0004360 biolink:MolecularActivity glutamine-fructose-6-phosphate transaminase (isomerizing) activity Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. EC:2.6.1.16|KEGG_REACTION:R00768|MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN|RHEA:13237|Reactome:R-HSA-4085027|Reactome:R-HSA-449715 go.json D-fructose-6-phosphate amidotransferase activity|GlcN6P synthase activity|L-glutamine-D-fructose-6-phosphate amidotransferase activity|L-glutamine:D-fructose-6-phosphate isomerase (deaminating)|glucosamine 6-phosphate synthase activity|glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity|glucosamine-6-phosphate isomerase (glutamine-forming) activity|glucosamine-6-phosphate synthase activity|glucosaminephosphate isomerase|hexosephosphate aminotransferase activity http://purl.obolibrary.org/obo/GO_0004360 GO:0102910 biolink:MolecularActivity dirigent protein activity Catalysis of the reaction: 2 H+ + 2 coniferol + O2 = (+)-pinoresinol + 2 H2O. MetaCyc:RXN-8677 go.json http://purl.obolibrary.org/obo/GO_0102910 GO:0102913 biolink:MolecularActivity 3-aminomethylindole N-methyltransferase activity Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine. MetaCyc:RXN-8686|RHEA:52268 go.json http://purl.obolibrary.org/obo/GO_0102913 GO:0102912 biolink:MolecularActivity (-)-lactol dehydrogenase activity Catalysis of the reaction: (-)-lactol + NAD = H+ + (-)-matairesinol + NADH. MetaCyc:RXN-8681 go.json http://purl.obolibrary.org/obo/GO_0102912 GO:0102915 biolink:MolecularActivity piperitol synthase activity Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 = (+)-piperitol + NADP + 2 H2O. EC:1.14.19.74|MetaCyc:RXN-8695|RHEA:56776 go.json http://purl.obolibrary.org/obo/GO_0102915 GO:0102914 biolink:MolecularActivity N-methyl-3-aminomethylindole N-methyltransferase activity Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine. MetaCyc:RXN-8687|RHEA:52272 go.json http://purl.obolibrary.org/obo/GO_0102914 GO:0102917 biolink:MolecularActivity (S)-reticuline 7-O-methyltransferase activity Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine = H+ + laudanine(1+) + S-adenosyl-L-homocysteine. EC:2.1.1.291|MetaCyc:RXN-8700|RHEA:10444 go.json http://purl.obolibrary.org/obo/GO_0102917 GO:0102916 biolink:MolecularActivity sesamin synthase activity Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 = (+)-sesamin + NADP + 2 H2O. EC:1.14.19.74|MetaCyc:RXN-8696 go.json http://purl.obolibrary.org/obo/GO_0102916 GO:0102919 biolink:MolecularActivity 5,6-dimethylbenzimidazole synthase activity Catalysis of the reaction: FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid. EC:1.13.11.79|MetaCyc:RXN-8771|RHEA:27345 go.json http://purl.obolibrary.org/obo/GO_0102919 GO:0102918 biolink:MolecularActivity (R)-reticuline 7-O-methyltransferase activity Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine = (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+. EC:2.1.1.291|MetaCyc:RXN-8701|RHEA:38907 go.json http://purl.obolibrary.org/obo/GO_0102918 GO:0004378 biolink:MolecularActivity GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage. EC:2.4.1.132|MetaCyc:RXN-5462|RHEA:29515 go.json GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity|GDP-mannose-oligosaccharide-lipid mannosyltransferase II|GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity|glycolipid 3-alpha-mannosyltransferase activity|guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity|mannosyltransferase II activity http://purl.obolibrary.org/obo/GO_0004378 GO:0004377 biolink:MolecularActivity GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. EC:2.4.1.131|MetaCyc:RXN-5464|RHEA:29523 go.json GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity|GDP-mannose-oligosaccharide-lipid mannosyltransferase activity|GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity|glycolipid 2-alpha-mannosyltransferase activity|guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity|oligosaccharide-lipid mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0004377 GO:0004379 biolink:MolecularActivity glycylpeptide N-tetradecanoyltransferase activity Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. EC:2.3.1.97|MetaCyc:2.3.1.97-RXN|RHEA:15521|Reactome:R-HSA-184392|Reactome:R-HSA-2534087 go.json N-myristoyltransferase activity|myristoyl-CoA-protein N-myristoyltransferase activity|myristoyl-coenzyme A:protein N-myristoyl transferase activity|myristoylating enzymes|peptide N-myristoyltransferase activity|peptide N-tetradecanoyltransferase activity|protein N-myristoyltransferase activity|tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity http://purl.obolibrary.org/obo/GO_0004379 GO:0004374 biolink:MolecularActivity obsolete glycine cleavage system OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating). go.json glycine cleavage system|glycine synthase True http://purl.obolibrary.org/obo/GO_0004374 GO:0004373 biolink:MolecularActivity glycogen (starch) synthase activity Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). EC:2.4.1.11|MetaCyc:RXN-7668|RHEA:18549|Reactome:R-HSA-3322001|Reactome:R-HSA-3322009|Reactome:R-HSA-3322041|Reactome:R-HSA-3828061|Reactome:R-HSA-3858506 go.json UDP-glucose-glycogen glucosyltransferase activity|UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity|UDP-glycogen synthase activity|UDPG-glycogen synthetase activity|UDPG-glycogen transglucosylase activity|UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity|glycogen (starch) synthetase activity|uridine diphosphoglucose-glycogen glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0004373 GO:0004376 biolink:MolecularActivity glycolipid mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. Reactome:R-HSA-162821|Reactome:R-HSA-162873 go.json glycolipid mannosyl transferase activity http://purl.obolibrary.org/obo/GO_0004376 GO:0004375 biolink:MolecularActivity glycine dehydrogenase (decarboxylating) activity Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. EC:1.4.4.2|MetaCyc:GCVP-RXN|RHEA:24304|Reactome:R-HSA-5693967 go.json P-protein|glycine cleavage system P-protein activity|glycine decarboxylase activity|glycine-cleavage complex|glycine-cleavage complex P-protein activity|glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)|glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)|protein P1 http://purl.obolibrary.org/obo/GO_0004375 GO:0004370 biolink:MolecularActivity glycerol kinase activity Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+. EC:2.7.1.30|KEGG_REACTION:R00847|MetaCyc:GLYCEROL-KIN-RXN|RHEA:21644|Reactome:R-HSA-75887 go.json ATP:glycerol 3-phosphotransferase activity|ATP:glycerol-3-phosphotransferase activity|GK|glyceric kinase activity|glycerokinase activity|glycerol kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004370 GO:0102920 biolink:MolecularActivity acyl coenzyme A: isopenicillin N acyltransferase activity Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O = H+ + coenzyme A + penicillin K + L-2-aminoadipate. EC:2.3.1.164|MetaCyc:RXN-8809 go.json http://purl.obolibrary.org/obo/GO_0102920 GO:0102922 biolink:MolecularActivity phenylpropanoyltransferase activity Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A. MetaCyc:RXN-8857|RHEA:42488 go.json http://purl.obolibrary.org/obo/GO_0102922 GO:0004372 biolink:MolecularActivity glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. EC:2.1.2.1|MetaCyc:GLYOHMETRANS-RXN|RHEA:15481|Reactome:R-HSA-5694137 go.json 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity|L-serine hydroxymethyltransferase activity|allothreonine aldolase activity|serine aldolase activity|serine hydroxymethylase activity|serine hydroxymethyltransferase activity|serine transhydroxymethylase activity http://purl.obolibrary.org/obo/GO_0004372 GO:0004371 biolink:MolecularActivity glycerone kinase activity Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. EC:2.7.1.29|KEGG_REACTION:R01011|MetaCyc:GLYCERONE-KINASE-RXN|RHEA:15773 go.json ATP:glycerone phosphotransferase activity|acetol kinase (phosphorylating)|acetol kinase activity|dihydroxyacetone kinase activity http://purl.obolibrary.org/obo/GO_0004371 GO:0102921 biolink:MolecularActivity mannosylglycerate synthase activity Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate = H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP. EC:2.4.1.269|MetaCyc:RXN-8849|RHEA:30639 go.json http://purl.obolibrary.org/obo/GO_0102921 GO:0102924 biolink:MolecularActivity gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide. MetaCyc:RXN-886 go.json http://purl.obolibrary.org/obo/GO_0102924 GO:0102923 biolink:MolecularActivity 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A. MetaCyc:RXN-8859|RHEA:33687 go.json http://purl.obolibrary.org/obo/GO_0102923 GO:0102926 biolink:MolecularActivity solanidine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP. MetaCyc:RXN-8882 go.json http://purl.obolibrary.org/obo/GO_0102926 GO:0102925 biolink:MolecularActivity solanine UDP-galactose galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP. MetaCyc:RXN-8875 go.json http://purl.obolibrary.org/obo/GO_0102925 GO:0102928 biolink:MolecularActivity beta-solanine rhamnosyltransferase activity Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP. MetaCyc:RXN-8884 go.json http://purl.obolibrary.org/obo/GO_0102928 GO:0102927 biolink:MolecularActivity beta-chaconine rhamnosyltransferase activity Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP. MetaCyc:RXN-8883 go.json http://purl.obolibrary.org/obo/GO_0102927 GO:0102929 biolink:MolecularActivity lachrymatory factor synthase activity Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide. MetaCyc:RXN-8911 go.json http://purl.obolibrary.org/obo/GO_0102929 GO:0004349 biolink:MolecularActivity glutamate 5-kinase activity Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+. EC:2.7.2.11|KEGG_REACTION:R00239|MetaCyc:GLUTKIN-RXN|RHEA:14877 go.json ATP-L-glutamate 5-phosphotransferase activity|ATP:L-glutamate 5-phosphotransferase activity|ATP:gamma-L-glutamate phosphotransferase activity|gamma-glutamate kinase activity|gamma-glutamyl kinase activity|glutamate kinase activity http://purl.obolibrary.org/obo/GO_0004349 GO:0004348 biolink:MolecularActivity glucosylceramidase activity Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. EC:3.2.1.45|MetaCyc:GLUCOSYLCERAMIDASE-RXN|RHEA:13269|Reactome:R-HSA-1605591|Reactome:R-HSA-1861788|Reactome:R-HSA-1861789 go.json D-glucosyl-N-acylsphingosine glucohydrolase activity|GlcCer-beta-glucosidase activity|acid beta-glucosidase activity|beta-D-glucocerebrosidase activity|beta-glucocerebrosidase activity|beta-glucosylceramidase activity|ceramide glucosidase activity|glucocerebrosidase activity|glucosphingosine glucosylhydrolase activity|glucosylcerebrosidase activity|glucosylsphingosine beta-D-glucosidase activity|glucosylsphingosine beta-glucosidase activity|psychosine hydrolase activity http://purl.obolibrary.org/obo/GO_0004348 GO:0004345 biolink:MolecularActivity glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. EC:1.1.1.49|MetaCyc:GLU6PDEHYDROG-RXN|RHEA:15841|Reactome:R-HSA-70377 go.json 6-phosphoglucose dehydrogenas|6-phosphoglucose dehydrogenase activity|D-glucose 6-phosphate dehydrogenase activity|D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity|Entner-doudoroff enzyme|G6PD activity|G6PDH|GDH|NADP-dependent glucose 6-phosphate dehydrogenase activity|NADP-glucose-6-phosphate dehydrogenase activity|Zwischenferment|glucose 6-phosphate dehydrogenase (NADP) activity|glucose-6-phosphate 1-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004345 GO:0004344 biolink:MolecularActivity glucose dehydrogenase activity Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. EC:1.1.99.35|RHEA:24540 go.json glucose dehydrogenase (acceptor) activity|soluble glucose dehydrogenase http://purl.obolibrary.org/obo/GO_0004344 GO:0004347 biolink:MolecularActivity glucose-6-phosphate isomerase activity Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. EC:5.3.1.9|MetaCyc:PGLUCISOM-RXN|RHEA:11816|Reactome:R-HSA-70471|Reactome:R-HSA-70475 go.json D-glucose-6-phosphate aldose-ketose-isomerase activity|D-glucose-6-phosphate ketol-isomerase activity|glucose phosphate isomerase activity|hexose monophosphate isomerase activity|hexose phosphate isomerase activity|hexosephosphate isomerase activity|oxoisomerase activity|phosphoglucoisomerase activity|phosphoglucose isomerase activity|phosphohexoisomerase activity|phosphohexomutase activity|phosphohexose isomerase activity|phosphosaccharomutase activity http://purl.obolibrary.org/obo/GO_0004347 GO:0004346 biolink:MolecularActivity glucose-6-phosphatase activity Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate. EC:3.1.3.9|KEGG_REACTION:R00303|MetaCyc:RXN66-526|RHEA:16689|Reactome:R-HSA-3262512|Reactome:R-HSA-3266566|Reactome:R-HSA-3274540|Reactome:R-HSA-3282876|Reactome:R-HSA-71825 go.json D-glucose-6-phosphate phosphohydrolase activity|glucose 6-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0004346 GO:0004341 biolink:MolecularActivity gluconolactonase activity Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. EC:3.1.1.17|MetaCyc:GLUCONOLACT-RXN|RHEA:10440 go.json D-glucono-1,5-lactone lactonohydrolase activity|aldonolactonase activity|glucono-delta-lactonase activity|gulonolactonase activity|lactonase activity http://purl.obolibrary.org/obo/GO_0004341 GO:0004340 biolink:MolecularActivity glucokinase activity Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. EC:2.7.1.2|MetaCyc:GLUCOKIN-RXN|RHEA:17825|Reactome:R-HSA-5621888|Reactome:R-HSA-5621918|Reactome:R-HSA-70420 go.json ATP:D-glucose 6-phosphotransferase activity|glucokinase (phosphorylating)|glucose kinase activity http://purl.obolibrary.org/obo/GO_0004340 GO:0004343 biolink:MolecularActivity glucosamine 6-phosphate N-acetyltransferase activity Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+. EC:2.3.1.4|KEGG_REACTION:R02058|MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN|RHEA:10292|Reactome:R-HSA-449734 go.json D-glucosamine-6-P N-acetyltransferase activity|N-acetylglucosamine-6-phosphate synthase activity|acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity|aminodeoxyglucosephosphate acetyltransferase activity|glucosamine 6-phosphate acetylase activity|glucosamine-6-phosphate acetylase activity|glucosamine-phosphate N-acetyltransferase activity|phosphoglucosamine N-acetylase activity|phosphoglucosamine acetylase activity|phosphoglucosamine transacetylase activity http://purl.obolibrary.org/obo/GO_0004343 GO:0004342 biolink:MolecularActivity glucosamine-6-phosphate deaminase activity Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4. EC:3.5.99.6|KEGG_REACTION:R00765|MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN|RHEA:12172|Reactome:R-HSA-6799604 go.json 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)|GlcN6P deaminase activity|aminodeoxyglucosephosphate isomerase activity|glucosamine phosphate deaminase activity|glucosamine-6-phosphate isomerase activity|glucosaminephosphate isomerase|phosphoglucosamine isomerase activity|phosphoglucosaminisomerase activity http://purl.obolibrary.org/obo/GO_0004342 GO:0102931 biolink:MolecularActivity (Z,E)-alpha- farnesene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid. MetaCyc:RXN-8931 go.json http://purl.obolibrary.org/obo/GO_0102931 GO:0102930 biolink:MolecularActivity 4-hydroxybenzoate geranyltransferase activity Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid. EC:2.5.1.93|MetaCyc:RXN-8920|RHEA:27854 go.json http://purl.obolibrary.org/obo/GO_0102930 GO:0102933 biolink:MolecularActivity GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate. EC:2.6.1.102|MetaCyc:RXN-8953|RHEA:36779 go.json http://purl.obolibrary.org/obo/GO_0102933 GO:0102932 biolink:MolecularActivity pterocarpan reductase activity Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP. MetaCyc:RXN-8936 go.json http://purl.obolibrary.org/obo/GO_0102932 GO:0102935 biolink:MolecularActivity gypsogenin-UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP. MetaCyc:RXN-9012 go.json http://purl.obolibrary.org/obo/GO_0102935 GO:0102934 biolink:MolecularActivity costunolide synthase activity Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP. EC:1.14.14.150|MetaCyc:RXN-8971|RHEA:28230 go.json http://purl.obolibrary.org/obo/GO_0102934 GO:0018989 biolink:BiologicalProcess apolysis The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells. Wikipedia:Apolysis go.json http://purl.obolibrary.org/obo/GO_0018989 GO:0102937 biolink:MolecularActivity 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP. MetaCyc:RXN-9014 go.json http://purl.obolibrary.org/obo/GO_0102937 GO:0102936 biolink:MolecularActivity gypsogenate-UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP. MetaCyc:RXN-9013 go.json http://purl.obolibrary.org/obo/GO_0102936 GO:0102939 biolink:MolecularActivity 3-methoxy-5-hydroxytoluene O-methyltransferase activity Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine. MetaCyc:RXN-9018 go.json http://purl.obolibrary.org/obo/GO_0102939 GO:0018986 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018986 GO:0102938 biolink:MolecularActivity orcinol O-methyltransferase activity Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine. EC:2.1.1.6|MetaCyc:RXN-9017 go.json http://purl.obolibrary.org/obo/GO_0102938 GO:0018985 biolink:BiologicalProcess pronuclear envelope synthesis Synthesis and ordering of the envelope of pronuclei. go.json http://purl.obolibrary.org/obo/GO_0018985 GO:0018988 biolink:BiologicalProcess obsolete molting cycle, protein-based cuticle OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss. go.json protein-based cuticle molting cycle True http://purl.obolibrary.org/obo/GO_0018988 GO:0018987 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018987 GO:0018982 biolink:BiologicalProcess vanillin metabolic process The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin. UM-BBD_pathwayID:van go.json vanillic aldehyde metabolic process|vanillic aldehyde metabolism|vanillin metabolism http://purl.obolibrary.org/obo/GO_0018982 GO:0018981 biolink:BiologicalProcess obsolete triethanolamine metabolic process OBSOLETE. The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. UM-BBD_pathwayID:tea go.json triethanolamine metabolism True http://purl.obolibrary.org/obo/GO_0018981 GO:0018984 biolink:BiologicalProcess naphthalenesulfonate metabolic process The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene. UM-BBD_pathwayID:nphs go.json naphthalenesulfonate metabolism|naphthalenesulphonate metabolic process|naphthalenesulphonate metabolism http://purl.obolibrary.org/obo/GO_0018984 GO:0018983 biolink:BiologicalProcess Z-phenylacetaldoxime metabolic process The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants. UM-BBD_pathwayID:pao go.json Z-phenylacetaldoxime metabolism http://purl.obolibrary.org/obo/GO_0018983 GO:0018980 biolink:BiologicalProcess 2,4,5-trichlorophenoxyacetic acid metabolic process The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns. UM-BBD_pathwayID:2,4,5-t go.json 2,4,5-T metabolic process|2,4,5-T metabolism|2,4,5-trichlorophenoxyacetic acid metabolism http://purl.obolibrary.org/obo/GO_0018980 GO:0004359 biolink:MolecularActivity glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. EC:3.5.1.2|MetaCyc:GLUTAMIN-RXN|RHEA:15889|Reactome:R-HSA-70609 go.json L-glutaminase activity|L-glutamine amidohydrolase activity|glutaminase I|glutamine aminohydrolase activity http://purl.obolibrary.org/obo/GO_0004359 GO:0004356 biolink:MolecularActivity glutamine synthetase activity Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. EC:6.3.1.2|KEGG_REACTION:R00253|MetaCyc:GLUTAMINESYN-RXN|RHEA:16169|Reactome:R-HSA-70606 go.json L-glutamine synthetase activity|glutamate-ammonia ligase activity http://purl.obolibrary.org/obo/GO_0004356 GO:0004355 biolink:MolecularActivity glutamate synthase (NADPH) activity Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+. EC:1.4.1.13|KEGG_REACTION:R00114|MetaCyc:GLUGLNSYN-PWY|MetaCyc:GLUTAMATESYN-RXN|MetaCyc:GLUTSYN-PWY|RHEA:15501 go.json GOGAT activity|L-glutamate synthase activity|L-glutamate synthetase activity|L-glutamate:NADP+ oxidoreductase (transaminating)|L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity|NADPH GOGAT|NADPH-dependent glutamate synthase activity|NADPH-glutamate synthase activity|NADPH-linked glutamate synthase|glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity|glutamate synthetase (NADP) activity|glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity|glutamine-ketoglutaric aminotransferase activity http://purl.obolibrary.org/obo/GO_0004355 GO:0004358 biolink:MolecularActivity glutamate N-acetyltransferase activity Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. EC:2.3.1.35|KEGG_REACTION:R02282|MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN|RHEA:15349 go.json 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity|N-acetyl-L-glutamate synthetase activity|N-acetylglutamate synthase activity|N-acetylglutamate synthetase activity|N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity|acetylglutamate synthetase activity|acetylglutamate-acetylornithine transacetylase activity|acetylglutamic synthetase activity|acetylglutamic-acetylornithine transacetylase activity|acetylornithinase activity|acetylornithine glutamate acetyltransferase activity|alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity|glutamate acetyltransferase activity|ornithine acetyltransferase activity|ornithine transacetylase activity http://purl.obolibrary.org/obo/GO_0004358 GO:0004357 biolink:MolecularActivity glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. EC:6.3.2.2|KEGG_REACTION:R00894|MetaCyc:GLUTCYSLIG-RXN|RHEA:13285|Reactome:R-HSA-174367|Reactome:R-HSA-5602892 go.json L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity|gamma-glutamyl-L-cysteine synthetase activity|gamma-glutamylcysteine synthetase activity|gamma-glutamylcysteinyl synthetase activity http://purl.obolibrary.org/obo/GO_0004357 GO:0004352 biolink:MolecularActivity glutamate dehydrogenase (NAD+) activity Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. EC:1.4.1.2|MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN|RHEA:15133 go.json L-glutamate dehydrogenase|L-glutamate:NAD+ oxidoreductase (deaminating)|NAD-dependent glutamate dehydrogenase activity|NAD-dependent glutamic dehydrogenase activity|NAD-glutamate dehydrogenase activity|NAD-linked glutamate dehydrogenase activity|NAD-linked glutamic dehydrogenase activity|NAD-specific glutamate dehydrogenase activity|NAD-specific glutamic dehydrogenase activity|NAD:glutamate oxidoreductase activity|NADH-linked glutamate dehydrogenase activity|glutamate dehydrogenase (NAD)|glutamate oxidoreductase activity|glutamic acid dehydrogenase|glutamic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004352 GO:0004351 biolink:MolecularActivity glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. EC:4.1.1.15|MetaCyc:GLUTDECARBOX-RXN|RHEA:17785|Reactome:R-HSA-888572|Reactome:R-HSA-888577 go.json L-aspartate-alpha-decarboxylase activity|L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)|L-glutamate 1-carboxy-lyase activity|L-glutamate alpha-decarboxylase activity|L-glutamic acid decarboxylase activity|L-glutamic decarboxylase activity|aspartic alpha-decarboxylase|cysteic acid decarboxylase activity|gamma-glutamate decarboxylase activity http://purl.obolibrary.org/obo/GO_0004351 GO:0004354 biolink:MolecularActivity glutamate dehydrogenase (NADP+) activity Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. EC:1.4.1.4|MetaCyc:GLUTDEHYD-RXN|MetaCyc:GLUTSYNIII-PWY|RHEA:11612 go.json L-glutamate dehydrogenase|L-glutamate:NADP+ oxidoreductase (deaminating)|L-glutamic acid dehydrogenase activity|NAD(P)-glutamate dehydrogenase activity|NAD(P)H-dependent glutamate dehydrogenase activity|dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))|glutamic acid dehydrogenase|glutamic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004354 GO:0102940 biolink:MolecularActivity phloroglucinol O-methyltransferase activity Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine. MetaCyc:RXN-9020 go.json http://purl.obolibrary.org/obo/GO_0102940 GO:0004353 biolink:MolecularActivity glutamate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. EC:1.4.1.3|MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN|MetaCyc:GLUTAMATE-SYN2-PWY|Reactome:R-HSA-70589|Reactome:R-HSA-70600 go.json L-glutamate:NAD(P)+ oxidoreductase (deaminating)|glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)|glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)|glutamic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004353 GO:0102942 biolink:MolecularActivity 3,5-dimethoxyphenol O-methyltransferase activity Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine. MetaCyc:RXN-9022 go.json http://purl.obolibrary.org/obo/GO_0102942 GO:0102941 biolink:MolecularActivity 3,5-dihydroxyanisole O-methyltransferase activity Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine. MetaCyc:RXN-9021 go.json http://purl.obolibrary.org/obo/GO_0102941 GO:0004350 biolink:MolecularActivity glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH. EC:1.2.1.41|KEGG_REACTION:R03313|MetaCyc:GLUTSEMIALDEHYDROG-RXN|RHEA:19541 go.json L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)|beta-glutamylphosphate reductase activity|gamma-glutamyl phosphate reductase activity|gamma-glutamylphosphate reductase activity|glutamate semialdehyde dehydrogenase activity|glutamate-gamma-semialdehyde dehydrogenase activity|glutamate-phosphate reductase activity|glutamyl-gamma-semialdehyde dehydrogenase activity|glutamylphosphate reductase activity http://purl.obolibrary.org/obo/GO_0004350 GO:0102944 biolink:MolecularActivity medicagenate UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate = UDP(3-) + a medicagenate monoglucoside. MetaCyc:RXN-9035 go.json http://purl.obolibrary.org/obo/GO_0102944 GO:0102943 biolink:MolecularActivity trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate. EC:5.3.3.17|MetaCyc:RXN-9031|RHEA:28182 go.json http://purl.obolibrary.org/obo/GO_0102943 GO:0102946 biolink:MolecularActivity soyasapogenol E UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E = UDP + a soyasapogenol E monoglucoside. MetaCyc:RXN-9038 go.json http://purl.obolibrary.org/obo/GO_0102946 GO:0102945 biolink:MolecularActivity soyasapogenol B UDP-glucosyl transferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B = UDP(3-) + a soyasapogenol B monoglucoside. MetaCyc:RXN-9037 go.json http://purl.obolibrary.org/obo/GO_0102945 GO:0102948 biolink:MolecularActivity luteolin C-glucosyltransferase activity Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor. MetaCyc:RXN-9081 go.json http://purl.obolibrary.org/obo/GO_0102948 GO:0102947 biolink:MolecularActivity (+)-delta-cadinene-8-hydroxylase activity Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 = 8-hydroxy-(+)-delta-cadinene + NADP + H2O. MetaCyc:RXN-9045 go.json http://purl.obolibrary.org/obo/GO_0102947 GO:0018997 biolink:MolecularActivity obsolete electron transfer carrier OBSOLETE. (Was not defined before being made obsolete). go.json electron transfer carrier True http://purl.obolibrary.org/obo/GO_0018997 GO:0018996 biolink:BiologicalProcess molting cycle, collagen and cuticulin-based cuticle The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans. go.json collagen and cuticulin-based cuticle molting cycle http://purl.obolibrary.org/obo/GO_0018996 GO:0102949 biolink:MolecularActivity 1,2-rhamnosyltransferase activity Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor. MetaCyc:RXN-9082 go.json http://purl.obolibrary.org/obo/GO_0102949 GO:0018999 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018999 GO:0018998 biolink:CellularComponent obsolete metaxin OBSOLETE. (Was not defined before being made obsolete). go.json metaxin True http://purl.obolibrary.org/obo/GO_0018998 GO:0018993 biolink:BiologicalProcess somatic sex determination The determination of sex and sexual phenotypes in an organism's soma. go.json http://purl.obolibrary.org/obo/GO_0018993 GO:0018992 biolink:BiologicalProcess germ-line sex determination The determination of sex and sexual phenotype in an organism's germ line. go.json http://purl.obolibrary.org/obo/GO_0018992 GO:0018995 biolink:CellularComponent host cellular component Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. Wikipedia:Host_(biology) go.json host organism http://purl.obolibrary.org/obo/GO_0018995 GO:0018994 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018994 GO:0018991 biolink:BiologicalProcess egg-laying behavior A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water. Wikipedia:Oviposition go.json egg laying|egg-laying|oviposition|post-mating oviposition http://purl.obolibrary.org/obo/GO_0018991 GO:0018990 biolink:BiologicalProcess ecdysis, chitin-based cuticle The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0018990 GO:0004327 biolink:MolecularActivity obsolete formaldehyde dehydrogenase (glutathione) activity OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+. go.json formaldehyde dehydrogenase (glutathione) activity True http://purl.obolibrary.org/obo/GO_0004327 GO:0004326 biolink:MolecularActivity tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). EC:6.3.2.17|MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN|RHEA:10580|Reactome:R-HSA-197958|Reactome:R-HSA-200681|Reactome:R-HSA-200682 go.json FPGS activity|N(10)-formyltetrahydropteroyldiglutamate synthetase activity|N10-formyltetrahydropteroyldiglutamate synthetase activity|folate polyglutamate synthetase activity|folylpoly(gamma-glutamate) synthase activity|folylpoly-gamma-glutamate synthase activity|folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity|folylpolyglutamate synthase activity|folylpolyglutamate synthetase activity|folylpolyglutamyl synthetase activity|formyltetrahydropteroyldiglutamate synthetase activity|tetrahydrofolate synthase activity|tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity|tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)|tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0004326 GO:0004329 biolink:MolecularActivity formate-tetrahydrofolate ligase activity Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. EC:6.3.4.3|MetaCyc:FORMATETHFLIG-RXN|RHEA:20221|Reactome:R-HSA-200711|Reactome:R-HSA-5696839|Reactome:R-HSA-6801456 go.json 10-formyl-THF synthetase activity|10-formyltetrahydrofolate synthetase activity|formate:tetrahydrofolate ligase (ADP-forming)|formyltetrahydrofolate synthetase activity|tetrahydrofolate formylase activity|tetrahydrofolic formylase activity http://purl.obolibrary.org/obo/GO_0004329 GO:0004328 biolink:MolecularActivity formamidase activity Catalysis of the reaction: formamide + H2O = formate + NH4. EC:3.5.1.49|KEGG_REACTION:R00524|MetaCyc:FORMAMIDASE-RXN|RHEA:21948|UM-BBD_reactionID:r0873 go.json formamide amidohydrolase activity|formamide hydrolase activity http://purl.obolibrary.org/obo/GO_0004328 GO:0004323 biolink:MolecularActivity obsolete multicopper ferroxidase iron transport mediator activity OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. go.json multicopper ferroxidase iron transport mediator activity True http://purl.obolibrary.org/obo/GO_0004323 GO:0004322 biolink:MolecularActivity ferroxidase activity Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. EC:1.16.3.1|MetaCyc:RXN0-1483|RHEA:11148|Reactome:R-HSA-1562603|Reactome:R-HSA-1562604|Reactome:R-HSA-1562626|Reactome:R-HSA-5621402|Reactome:R-HSA-5691107|Reactome:R-HSA-917891|Reactome:R-HSA-917933 go.json Fe(II):oxygen oxidoreductase activity|HEPH|caeruloplasmin|ceruloplasmin|ferro:O2 oxidoreductase activity|ferroxidase I|ferroxidase, iron II:oxygen oxidoreductase activity|hephaestin|iron(II): oxygen oxidoreductase activity|multicopper ferroxidase iron transport mediator activity http://purl.obolibrary.org/obo/GO_0004322 GO:0004325 biolink:MolecularActivity ferrochelatase activity Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX. EC:4.98.1.1|KEGG_REACTION:R00310|MetaCyc:PROTOHEMEFERROCHELAT-RXN|RHEA:22584|Reactome:R-HSA-189465 go.json ferro-protoporphyrin chelatase activity|heme synthase activity|heme synthetase activity|iron chelatase activity|protoheme ferro-lyase (protoporphyrin-forming)|protoheme ferro-lyase activity|protoheme ferrolyase activity http://purl.obolibrary.org/obo/GO_0004325 GO:0004324 biolink:MolecularActivity ferredoxin-NADP+ reductase activity Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. EC:1.18.1.2|MetaCyc:1.18.1.2-RXN|RHEA:20125 go.json NADP:ferredoxin oxidoreductase activity|NADPH:ferredoxin oxidoreductase activity|TPNH-ferredoxin reductase activity|ferredoxin-NADP oxidoreductase activity|ferredoxin-NADP reductase activity|ferredoxin-NADP-oxidoreductase activity|ferredoxin-TPN reductase activity|ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity|ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity|ferredoxin:NADP+ oxidoreductase activity|reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity http://purl.obolibrary.org/obo/GO_0004324 GO:0004321 biolink:MolecularActivity fatty-acyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. EC:2.3.1.86|MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN|RHEA:22896 go.json acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)|fatty acyl CoA synthase activity|yeast fatty acid synthase activity http://purl.obolibrary.org/obo/GO_0004321 GO:0004320 biolink:MolecularActivity oleoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: (9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H+ + holo-[ACP]. MetaCyc:3.1.2.14-RXN|RHEA:15057 go.json oleoyl-ACP hydrolase activity|oleoyl-ACP thioesterase activity|oleoyl-[acyl-carrier protein] hydrolase activity|oleoyl-acyl carrier protein thioesterase activity|oleoyl-acyl-carrier-protein hydrolase http://purl.obolibrary.org/obo/GO_0004320 GO:0018968 biolink:BiologicalProcess tetrahydrofuran metabolic process The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems. UM-BBD_pathwayID:thf go.json THF metabolic process|THF metabolism|tetrahydrofuran metabolism http://purl.obolibrary.org/obo/GO_0018968 GO:0018967 biolink:BiologicalProcess tetrachloroethylene metabolic process The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent. UM-BBD_pathwayID:tce2 go.json tetrachloroethene metabolic process|tetrachloroethene metabolism|tetrachloroethylene metabolism http://purl.obolibrary.org/obo/GO_0018967 GO:0018969 biolink:BiologicalProcess thiocyanate metabolic process The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries. MetaCyc:P581-PWY|UM-BBD_pathwayID:thc go.json thiocyanate metabolism|thiocyanic acid metabolic process|thiocyanic acid metabolism http://purl.obolibrary.org/obo/GO_0018969 GO:0018964 biolink:BiologicalProcess propylene metabolic process The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals. UM-BBD_pathwayID:pro go.json propylene metabolism http://purl.obolibrary.org/obo/GO_0018964 GO:0018963 biolink:BiologicalProcess phthalate metabolic process The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses. UM-BBD_pathwayID:pth go.json phthalate metabolism|phthalic acid metabolic process|phthalic acid metabolism http://purl.obolibrary.org/obo/GO_0018963 GO:0018966 biolink:BiologicalProcess styrene metabolic process The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen. UM-BBD_pathwayID:sty go.json styrene metabolism http://purl.obolibrary.org/obo/GO_0018966 GO:0018965 biolink:BiologicalProcess s-triazine compound metabolic process The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. UM-BBD_pathwayID:tria go.json s-triazine compound metabolism http://purl.obolibrary.org/obo/GO_0018965 GO:0018960 biolink:BiologicalProcess 4-nitrophenol metabolic process The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. UM-BBD_pathwayID:nphe go.json 4-nitrophenol metabolism|p-nitrophenol metabolic process|p-nitrophenol metabolism http://purl.obolibrary.org/obo/GO_0018960 GO:0018962 biolink:BiologicalProcess 3-phenylpropionate metabolic process The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins. UM-BBD_pathwayID:ppa go.json 3-phenylpropionate metabolism|hydrocinnamic acid metabolic process|hydrocinnamic acid metabolism|phenylpropanoate metabolic process|phenylpropanoate metabolism http://purl.obolibrary.org/obo/GO_0018962 GO:0018961 biolink:BiologicalProcess pentachlorophenol metabolic process The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. UM-BBD_pathwayID:pcp go.json PCP metabolic process|PCP metabolism|pentachlorophenol metabolism http://purl.obolibrary.org/obo/GO_0018961 GO:0004338 biolink:MolecularActivity glucan exo-1,3-beta-glucosidase activity Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose. EC:3.2.1.58|MetaCyc:3.2.1.58-RXN go.json 1,3-beta-glucan glucohydrolase activity|beta-1,3-glucan exo-hydrolase activity|exo (1->3)-beta-glucanase activity|exo-1,3-beta-D-glucanase activity|exo-1,3-beta-glucanase activity|exo-1,3-beta-glucosidase activity|exo-beta-(1->3)-D-glucanase activity|exo-beta-(1->3)-glucanohydrolase activity|exo-beta-1,3-D-glucanase activity|exo-beta-1,3-glucanase activity|glucan 1,3-beta-glucosidase activity http://purl.obolibrary.org/obo/GO_0004338 GO:0004337 biolink:MolecularActivity geranyltranstransferase activity Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. EC:2.5.1.10|KEGG_REACTION:R02003|MetaCyc:FPPSYN-RXN|RHEA:19361|Reactome:R-HSA-191303|Reactome:R-HSA-8870469|Reactome:R-HSA-9717830 go.json FPP synthetase activity|farnesyl diphosphate synthetase activity|farnesyl pyrophosphate synthetase activity|farnesyl-diphosphate synthase activity|farnesylpyrophosphate synthetase activity|geranyl transferase I|geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity|geranyltransferase activity http://purl.obolibrary.org/obo/GO_0004337 GO:0004339 biolink:MolecularActivity glucan 1,4-alpha-glucosidase activity Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. EC:3.2.1.3|MetaCyc:3.2.1.3-RXN go.json 1,4-alpha-D-glucan glucohydrolase activity|amyloglucosidase activity|exo-1,4-alpha-glucosidase activity|gamma-1,4-glucan glucohydrolase activity|gamma-amylase activity|glucoamylase activity|glucose amylase activity|lysosomal alpha-glucosidase activity http://purl.obolibrary.org/obo/GO_0004339 GO:0004334 biolink:MolecularActivity fumarylacetoacetase activity Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+. EC:3.7.1.2|KEGG_REACTION:R01364|MetaCyc:FUMARYLACETOACETASE-RXN|RHEA:10244|Reactome:R-HSA-71181|UM-BBD_reactionID:r0107 go.json 4-fumarylacetoacetate fumarylhydrolase activity|beta-diketonase activity|fumarylacetoacetate hydrolase activity http://purl.obolibrary.org/obo/GO_0004334 GO:0004333 biolink:MolecularActivity fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H2O. EC:4.2.1.2|KEGG_REACTION:R01082|MetaCyc:FUMHYDR-RXN|RHEA:12460|Reactome:R-HSA-451033|Reactome:R-HSA-70982 go.json (S)-malate hydro-lyase (fumarate-forming)|(S)-malate hydro-lyase activity|L-malate hydro-lyase activity|fumarase activity http://purl.obolibrary.org/obo/GO_0004333 GO:0004336 biolink:MolecularActivity galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. EC:3.2.1.46|MetaCyc:GALACTOSYLCERAMIDASE-RXN|RHEA:14297|Reactome:R-HSA-1606564 go.json D-galactosyl-N-acylsphingosine galactohydrolase activity|beta-galactocerebrosidase activity|beta-galactosylceramidase activity|ceramide galactosidase activity|cerebroside beta-galactosidase activity|cerebroside galactosidase activity|galactocerebrosidase activity|galactocerebroside beta-galactosidase activity|galactocerebroside galactosidase activity|galactocerebroside-beta-D-galactosidase activity|galactosylceramidase I|galactosylceramide beta-galactosidase activity|galactosylcerebrosidase activity|galcerase activity|lactosylceramidase I|lactosylceramidase activity http://purl.obolibrary.org/obo/GO_0004336 GO:0004335 biolink:MolecularActivity galactokinase activity Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+. EC:2.7.1.6|KEGG_REACTION:R01092|MetaCyc:GALACTOKIN-RXN|RHEA:13553|Reactome:R-HSA-5610026|Reactome:R-HSA-70355 go.json ATP:D-galactose 1-phosphotransferase activity|ATP:D-galactose-1-phosphotransferase activity|galactokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004335 GO:0004330 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004330 GO:0004332 biolink:MolecularActivity fructose-bisphosphate aldolase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. EC:4.1.2.13|MetaCyc:F16ALDOLASE-RXN|RHEA:14729|Reactome:R-HSA-71495|Reactome:R-HSA-71496 go.json 1,6-diphosphofructose aldolase activity|D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)|D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity|SMALDO|aldolase activity|diphosphofructose aldolase activity|fructoaldolase activity|fructose 1,6-diphosphate aldolase activity|fructose 1-monophosphate aldolase activity|fructose 1-phosphate aldolase activity|fructose diphosphate aldolase activity|fructose-1,6-bisphosphate triosephosphate-lyase activity|ketose 1-phosphate aldolase activity|phosphofructoaldolase activity|zymohexase activity http://purl.obolibrary.org/obo/GO_0004332 GO:0004331 biolink:MolecularActivity fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. EC:3.1.3.46|MetaCyc:3.1.3.46-RXN|RHEA:17289|Reactome:R-HSA-5628905|Reactome:R-HSA-70262 go.json D-fructose-2,6-bisphosphate 2-phosphohydrolase activity|beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity|fructose-2,6-bisphosphatase activity http://purl.obolibrary.org/obo/GO_0004331 GO:0018979 biolink:BiologicalProcess trichloroethylene metabolic process The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent. UM-BBD_pathwayID:tce go.json TCE metabolic process|TCE metabolism|trichloroethene metabolic process|trichloroethene metabolism|trichloroethylene metabolism http://purl.obolibrary.org/obo/GO_0018979 GO:0018978 biolink:BiologicalProcess anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen. UM-BBD_pathwayID:ddt2 go.json anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism|anaerobic DDT metabolic process|anaerobic DDT metabolism http://purl.obolibrary.org/obo/GO_0018978 GO:0018975 biolink:BiologicalProcess anaerobic 2,4,6-trinitrotoluene metabolic process The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen. UM-BBD_pathwayID:tnt2 go.json anaerobic 2,4,6-trinitrotoluene metabolism http://purl.obolibrary.org/obo/GO_0018975 GO:0018974 biolink:BiologicalProcess 2,4,6-trinitrotoluene metabolic process The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives. go.json 2,4,6-trinitrotoluene metabolism|TNT metabolic process|TNT metabolism http://purl.obolibrary.org/obo/GO_0018974 GO:0018977 biolink:BiologicalProcess 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. UM-BBD_pathwayID:ddt go.json 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism|DDT metabolic process|DDT metabolism http://purl.obolibrary.org/obo/GO_0018977 GO:0018976 biolink:BiologicalProcess 1,2,3-tribromopropane metabolic process The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture. UM-BBD_pathwayID:tbp go.json 1,2,3-tribromopropane metabolism http://purl.obolibrary.org/obo/GO_0018976 GO:0018971 biolink:BiologicalProcess anaerobic toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen. UM-BBD_pathwayID:tol2 go.json anaerobic toluene metabolism http://purl.obolibrary.org/obo/GO_0018971 GO:0018970 biolink:BiologicalProcess toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications. go.json methylbenzene metabolic process|methylbenzene metabolism|toluene metabolism http://purl.obolibrary.org/obo/GO_0018970 GO:0018973 biolink:BiologicalProcess trinitrotoluene metabolic process The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene. UM-BBD_pathwayID:tnt go.json trinitrotoluene metabolism http://purl.obolibrary.org/obo/GO_0018973 GO:0018972 biolink:BiologicalProcess toluene-4-sulfonate metabolic process The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water. MetaCyc:TOLSULFDEG-PWY|UM-BBD_pathwayID:tsa go.json 4-methylbenzenesulfonate metabolic process|4-methylbenzenesulfonate metabolism|4-toluenesulfonate metabolic process|4-toluenesulfonate metabolism|toluene-4-sulfonate metabolism|toluene-4-sulphonate metabolic process|toluene-4-sulphonate metabolism http://purl.obolibrary.org/obo/GO_0018972 GO:0004305 biolink:MolecularActivity ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine. EC:2.7.1.82|KEGG_REACTION:R01468|MetaCyc:ETHANOLAMINE-KINASE-RXN|RHEA:13069|Reactome:R-HSA-1483222 go.json ATP:ethanolamine O-phosphotransferase activity|ethanolamine kinase (phosphorylating)|ethanolamine phosphokinase activity http://purl.obolibrary.org/obo/GO_0004305 GO:0004304 biolink:MolecularActivity estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. EC:2.8.2.4|MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN|RHEA:15973|Reactome:R-HSA-176664 go.json 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity|3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity|3'-phosphoadenylylsulfate:oestrone sulfotransferase activity|estrogen sulfotransferase|estrogen sulphotransferase activity|estrone sulphotransferase activity|oestrogen sulphotransferase activity http://purl.obolibrary.org/obo/GO_0004304 GO:0004307 biolink:MolecularActivity ethanolaminephosphotransferase activity Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. EC:2.7.8.1|MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN|RHEA:32943|Reactome:R-HSA-1482962 go.json CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity|CDPethanolamine diglyceride phosphotransferase activity|EPT|diacylglycerol ethanolaminephosphotransferase activity|phosphorylethanolamine-glyceride transferase activity http://purl.obolibrary.org/obo/GO_0004307 GO:0004306 biolink:MolecularActivity ethanolamine-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. EC:2.7.7.14|MetaCyc:2.7.7.14-RXN|RHEA:24592|Reactome:R-HSA-1483190 go.json CTP-phosphoethanolamine cytidylyltransferase activity|CTP:ethanolamine-phosphate cytidylyltransferase activity|CTP:phosphoethanolamine cytidylyltransferase activity|ET|ethanolamine phosphate cytidylyltransferase activity|phosphoethanolamine cytidylyltransferase activity|phosphorylethanolamine transferase activity http://purl.obolibrary.org/obo/GO_0004306 GO:0004301 biolink:MolecularActivity epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol. EC:3.3.2.10|MetaCyc:3.3.2.10-RXN|RHEA:19037|Reactome:R-HSA-2161961|Reactome:R-HSA-9018862|Reactome:R-HSA-9018877|Reactome:R-HSA-9020252|Reactome:R-HSA-9020253|Reactome:R-HSA-9020257|Reactome:R-HSA-9020258|Reactome:R-HSA-9020270|Reactome:R-HSA-9024890|Reactome:R-HSA-9024973|Reactome:R-HSA-9024993|Reactome:R-HSA-9025998|Reactome:R-HSA-9026000|Reactome:R-HSA-9026008|UM-BBD_enzymeID:e0397 go.json arene-oxide hydratase activity|aryl epoxide hydrase activity|cytosolic epoxide hydrolase activity|epoxide hydrase activity|epoxide hydratase activity|sEH|soluble epoxide hydrolase activity|trans-stilbene oxide hydrolase activity http://purl.obolibrary.org/obo/GO_0004301 goslim_chembl GO:0004300 biolink:MolecularActivity enoyl-CoA hydratase activity Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. EC:4.2.1.17|MetaCyc:ENOYL-COA-HYDRAT-RXN|Reactome:R-HSA-70830|Reactome:R-HSA-70870|Reactome:R-HSA-77256|Reactome:R-HSA-77277|Reactome:R-HSA-77301|Reactome:R-HSA-77314|Reactome:R-HSA-77325|Reactome:R-HSA-77333|Reactome:R-HSA-77344|UM-BBD_enzymeID:e0014 go.json (3S)-3-hydroxyacyl-CoA hydro-lyase activity|2-enoyl-CoA hydratase activity|2-octenoyl coenzyme A hydrase activity|3-hydroxy-fatty acyl-CoA dehydratase|3-hydroxyacyl-CoA dehydratase|acyl coenzyme A hydrase activity|beta-hydroxyacid dehydrase activity|beta-hydroxyacyl-CoA dehydrase activity|enol-CoA hydratase activity|enoyl hydrase activity|short-chain enoyl-CoA hydratase activity|unsaturated acyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0004300 GO:0004303 biolink:MolecularActivity estradiol 17-beta-dehydrogenase [NAD(P)] activity Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. EC:1.1.1.62|MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN|Reactome:R-HSA-5693390|Reactome:R-HSA-5696822|Reactome:R-HSA-6810594|Reactome:R-HSA-804969|Reactome:R-HSA-8862137 go.json 17-beta-HSD activity|17-beta-estradiol dehydrogenase activity|17-beta-hydroxysteroid dehydrogenase activity|17beta,20alpha-hydroxysteroid dehydrogenase activity|17beta-HSD|17beta-estradiol dehydrogenase activity|17beta-hydroxysteroid dehydrogenase activity|20alpha-hydroxysteroid dehydrogenase|estradiol 17-beta-dehydrogenase activity|estradiol 17beta-dehydrogenase activity|estradiol dehydrogenase activity|estradiol-17beta:NAD(P)+ 17-oxidoreductase activity|estrogen 17-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004303 GO:0004302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004302 GO:0018949 biolink:BiologicalProcess m-xylene metabolic process The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. UM-BBD_pathwayID:mxy go.json m-xylene metabolism|meta-xylene metabolic process|meta-xylene metabolism http://purl.obolibrary.org/obo/GO_0018949 GO:0018946 biolink:BiologicalProcess aerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen. UM-BBD_pathwayID:osi go.json aerobic organosilicon metabolism|aerobic organosilicone metabolic process|aerobic organosilicone metabolism http://purl.obolibrary.org/obo/GO_0018946 GO:0018945 biolink:BiologicalProcess organosilicon metabolic process The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon. UM-BBD_pathwayID:osi go.json organosilicon metabolism|organosilicone metabolic process|organosilicone metabolism http://purl.obolibrary.org/obo/GO_0018945 GO:0018948 biolink:BiologicalProcess xylene metabolic process The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. go.json xylene metabolism http://purl.obolibrary.org/obo/GO_0018948 GO:0018947 biolink:BiologicalProcess anaerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen. UM-BBD_pathwayID:osi go.json anaerobic organosilicon metabolism|anaerobic organosilicone metabolic process|anaerobic organosilicone metabolism http://purl.obolibrary.org/obo/GO_0018947 GO:0018942 biolink:BiologicalProcess organometal metabolic process The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms. go.json organometal metabolism http://purl.obolibrary.org/obo/GO_0018942 goslim_pir GO:0018941 biolink:BiologicalProcess organomercury metabolic process The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom. UM-BBD_pathwayID:ogm go.json organomercury metabolism http://purl.obolibrary.org/obo/GO_0018941 GO:0018944 biolink:BiologicalProcess tri-n-butyltin metabolic process The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms. UM-BBD_pathwayID:tbt go.json tri-n-butyltin metabolism http://purl.obolibrary.org/obo/GO_0018944 GO:0018943 biolink:BiologicalProcess organotin metabolic process The chemical reactions and pathways involving organotin, an organic compound containing a tin atom. go.json organotin metabolism http://purl.obolibrary.org/obo/GO_0018943 GO:0018940 biolink:BiologicalProcess orcinol metabolic process The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants. MetaCyc:P342-PWY|UM-BBD_pathwayID:orc go.json orcin metabolic process|orcin metabolism|orcinol metabolism http://purl.obolibrary.org/obo/GO_0018940 GO:0004309 biolink:MolecularActivity exopolyphosphatase activity Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. EC:3.6.1.11|MetaCyc:EXOPOLYPHOSPHATASE-RXN|RHEA:21528 go.json Gra-Pase activity|acid phosphoanhydride phosphohydrolase activity|exopolypase activity|metaphosphatase activity|polyphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0004309 GO:0004308 biolink:MolecularActivity exo-alpha-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. EC:3.2.1.18|MetaCyc:3.2.1.18-RXN|Reactome:R-HSA-1605723|Reactome:R-HSA-1605724|Reactome:R-HSA-1605768|Reactome:R-HSA-168870|Reactome:R-HSA-4084994|Reactome:R-HSA-4084999|Reactome:R-HSA-4085029|Reactome:R-HSA-4341669|Reactome:R-HSA-9638120 go.json N-acylneuraminate glycohydrolase activity|acetylneuraminidase activity|acetylneuraminyl hydrolase activity|alpha-neuraminidase activity|neuraminidase activity|sialidase activity http://purl.obolibrary.org/obo/GO_0004308 GO:0004316 biolink:MolecularActivity 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. EC:1.1.1.100|MetaCyc:3-OXOACYL-ACP-REDUCT-RXN|RHEA:17397|Reactome:R-HSA-8862152 go.json (3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity|3-ketoacyl acyl carrier protein reductase activity|3-oxoacyl-ACP reductase activity|3-oxoacyl-ACPreductase activity|3-oxoacyl-[acyl-carrier protein] reductase activity|3-oxoacyl-acyl-carrier-protein reductase activity|NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity|beta-ketoacyl acyl carrier protein (ACP) reductase activity|beta-ketoacyl reductase activity|beta-ketoacyl thioester reductase activity|beta-ketoacyl-ACP reductase activity|beta-ketoacyl-acyl carrier protein reductase activity|beta-ketoacyl-acyl-carrier protein(ACP) reductase activity http://purl.obolibrary.org/obo/GO_0004316 GO:0004315 biolink:MolecularActivity 3-oxoacyl-[acyl-carrier-protein] synthase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. EC:2.3.1.41|MetaCyc:2.3.1.179-RXN|MetaCyc:3-OXOACYL-ACP-SYNTH-RXN|RHEA:22836 go.json 3-ketoacyl-acyl carrier protein synthase activity|3-oxoacyl-ACP synthase activity|3-oxoacyl-[acyl-carrier protein] synthase activity|3-oxoacyl-acyl carrier protein synthase I activity|3-oxoacyl-acyl-carrier-protein synthase activity|acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)|acyl-malonyl acyl carrier protein-condensing enzyme activity|acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity|beta-ketoacyl acyl carrier protein synthase activity|beta-ketoacyl synthetase activity|beta-ketoacyl-ACP synthase I activity|beta-ketoacyl-ACP synthase II activity|beta-ketoacyl-ACP synthetase activity|beta-ketoacyl-[acyl carrier protein] synthase activity|beta-ketoacyl-acyl carrier protein synthase activity|beta-ketoacyl-acyl carrier protein synthetase activity|beta-ketoacyl-acyl-carrier-protein synthase I|beta-ketoacyl-acyl-carrier-protein synthase II activity|beta-ketoacylsynthase activity|condensing enzyme activity|fatty acid condensing enzyme activity|ketoacyl-ACP synthase activity http://purl.obolibrary.org/obo/GO_0004315 GO:0004318 biolink:MolecularActivity enoyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. EC:1.3.1.9|MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN|RHEA:10240 go.json NADH-enoyl acyl carrier protein reductase activity|NADH-specific enoyl-ACP reductase activity|acyl-acyl-carrier-protein:NAD+ oxidoreductase|enoyl-ACP reductase (NADH) activity|enoyl-[acyl-carrier protein] reductase (NADH) activity|enoyl-acyl-carrier-protein reductase (NADH) http://purl.obolibrary.org/obo/GO_0004318 GO:0004317 biolink:MolecularActivity (3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. KEGG_REACTION:R04462|MetaCyc:4.2.1.61-RXN|RHEA:41908 go.json (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity|(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)|(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity|3-hydroxypalmitoyl-ACP dehydratase activity|3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity|3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity http://purl.obolibrary.org/obo/GO_0004317 GO:0004312 biolink:MolecularActivity fatty acid synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. EC:2.3.1.85|MetaCyc:FATTY-ACID-SYNTHASE-RXN|RHEA:14993|Reactome:R-HSA-75872 go.json acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)|fatty-acid synthase activity http://purl.obolibrary.org/obo/GO_0004312 GO:0004311 biolink:MolecularActivity farnesyltranstransferase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. EC:2.5.1.29|KEGG_REACTION:R02061|MetaCyc:FARNESYLTRANSTRANSFERASE-RXN|RHEA:17653 go.json farnesyltransferase activity|geranylgeranyl pyrophosphate synthase activity|geranylgeranyl pyrophosphate synthetase activity|geranylgeranyl-PP synthetase activity|geranylgeranyl-diphosphate synthase activity|trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity http://purl.obolibrary.org/obo/GO_0004311 GO:0004314 biolink:MolecularActivity [acyl-carrier-protein] S-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. EC:2.3.1.39|MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN|Reactome:R-HSA-8933547 go.json ACP S-malonyltransferase activity|FabD|MAT|MCAT activity|[acyl-carrier protein] S-malonyltransferase activity|acyl carrier protein malonyltransferase activity|acyl carrier proteinmalonyltransferase activity|acyl-carrier-protein S-malonyltransferase activity|malonyl coenzyme A-acyl carrier protein transacylase activity|malonyl transacylase activity|malonyl transferase activity|malonyl-CoA-acyl carrier protein transacylase activity|malonyl-CoA:ACP transacylase activity|malonyl-CoA:AcpM transacylase activity|malonyl-CoA:acyl carrier protein transacylase activity|malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0004314 GO:0004313 biolink:MolecularActivity [acyl-carrier-protein] S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. EC:2.3.1.38|MetaCyc:ACP-S-ACETYLTRANSFER-RXN|RHEA:41788 go.json ACAT activity|ACP S-acetyltransferase activity|ACP acetyltransferase activity|ACPacetyltransferase activity|[acyl-carrier protein] S-acetyltransferase activity|acetyl coenzyme A-acyl-carrier-protein transacylase activity|acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity|acyl-carrier-protein S-acetyltransferase activity|acyl-carrier-protein acetyltransferase activity|acyl-carrier-proteinacetyltransferase activity http://purl.obolibrary.org/obo/GO_0004313 GO:0004310 biolink:MolecularActivity farnesyl-diphosphate farnesyltransferase activity Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. EC:2.5.1.21|MetaCyc:RXN-12263|Reactome:R-HSA-191402|Reactome:R-HSA-191405 go.json farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity|presqualene synthase activity|presqualene-diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0004310 GO:0102900 biolink:MolecularActivity dehydroabietadienal hydroxylase activity Catalysis of the reaction: dehydroabietadienal + NADPH + O2 = dehydroabietic acid + NADP + H2O. MetaCyc:RXN-8534 go.json http://purl.obolibrary.org/obo/GO_0102900 GO:0018957 biolink:BiologicalProcess phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite. UM-BBD_pathwayID:pha2 go.json phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene|phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene http://purl.obolibrary.org/obo/GO_0018957 GO:0102902 biolink:MolecularActivity isopimaradienal hydroxylase activity Catalysis of the reaction: isopimaradienal + NADPH + O2 = isopimaric acid + NADP + H2O. MetaCyc:RXN-8538 go.json http://purl.obolibrary.org/obo/GO_0102902 GO:0018956 biolink:BiologicalProcess phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite. UM-BBD_pathwayID:pha3 go.json phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene|phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene http://purl.obolibrary.org/obo/GO_0018956 GO:0102901 biolink:MolecularActivity isopimaradienol hydroxylase activity Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 = isopimaradiene-diol + NADP + H2O. MetaCyc:RXN-8536 go.json http://purl.obolibrary.org/obo/GO_0102901 GO:0018959 biolink:BiologicalProcess aerobic phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. UM-BBD_pathwayID:pba go.json aerobic phenol-containing compound metabolism http://purl.obolibrary.org/obo/GO_0018959 GO:0102904 biolink:MolecularActivity germacrene C synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid. EC:4.2.3.60|MetaCyc:RXN-8561|RHEA:28302 go.json http://purl.obolibrary.org/obo/GO_0102904 GO:0018958 biolink:BiologicalProcess phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. UM-BBD_pathwayID:phe go.json carbolic acid metabolic process|carbolic acid metabolism|hydroxybenzene metabolic process|hydroxybenzene metabolism|phenol-containing compound metabolism http://purl.obolibrary.org/obo/GO_0018958 GO:0102903 biolink:MolecularActivity gamma-terpinene synthase activity Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid. EC:4.2.3.114|MetaCyc:RXN-8547|RHEA:32559 go.json http://purl.obolibrary.org/obo/GO_0102903 GO:0018953 biolink:BiologicalProcess p-cymene metabolic process The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants. UM-BBD_pathwayID:pcy go.json p-cymene metabolism http://purl.obolibrary.org/obo/GO_0018953 GO:0102906 biolink:MolecularActivity 7-epi-alpha-selinene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (-)-7-epi-alpha-selinene + diphosphoric acid. EC:4.2.3.86|MetaCyc:RXN-8609|RHEA:30383 go.json http://purl.obolibrary.org/obo/GO_0102906 GO:0102905 biolink:MolecularActivity valencene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (+)-valencene + diphosphoric acid. EC:4.2.3.73|MetaCyc:RXN-8608|RHEA:29511 go.json http://purl.obolibrary.org/obo/GO_0102905 GO:0018952 biolink:BiologicalProcess parathion metabolic process The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition. UM-BBD_pathwayID:pthn go.json parathion metabolism http://purl.obolibrary.org/obo/GO_0018952 GO:0018955 biolink:BiologicalProcess phenanthrene metabolic process The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish. UM-BBD_pathwayID:pha go.json phenanthrene metabolism http://purl.obolibrary.org/obo/GO_0018955 GO:0102908 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102908 GO:0102907 biolink:MolecularActivity sesquisabinene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + sesquisabinene. MetaCyc:RXN-8622 go.json http://purl.obolibrary.org/obo/GO_0102907 GO:0018954 biolink:BiologicalProcess pentaerythritol tetranitrate metabolic process The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator. UM-BBD_pathwayID:petn go.json pentaerythritol tetranitrate metabolism http://purl.obolibrary.org/obo/GO_0018954 GO:0102909 biolink:MolecularActivity obsolete alpha-ketoglutarate reductase activity (NADH-dependent) OBSOLETE. Catalysis of the reaction: NAD + 2-hydroxyglutarate = H+ + 2-oxoglutarate + NADH. go.json True http://purl.obolibrary.org/obo/GO_0102909 GO:0018951 biolink:BiologicalProcess p-xylene metabolic process The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. UM-BBD_pathwayID:pxy go.json p-xylene metabolism|para-xylene metabolic process|para-xylene metabolism http://purl.obolibrary.org/obo/GO_0018951 GO:0018950 biolink:BiologicalProcess o-xylene metabolic process The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. UM-BBD_pathwayID:oxy go.json o-xylene metabolism|ortho-xylene metabolic process|ortho-xylene metabolism http://purl.obolibrary.org/obo/GO_0018950 GO:0004319 biolink:MolecularActivity enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+. EC:1.3.1.10|MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN go.json NADPH 2-enoyl Co A reductase activity|acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)|enoyl acyl-carrier-protein reductase activity|enoyl-ACP reductase (NADPH, B-specific) activity|enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity|enoyl-acyl-carrier-protein reductase (NADPH, B-specific)|enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)|reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) http://purl.obolibrary.org/obo/GO_0004319 GO:0102751 biolink:MolecularActivity UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+. EC:2.4.1.186|MetaCyc:RXN-7667|RHEA:56560 go.json http://purl.obolibrary.org/obo/GO_0102751 GO:0102750 biolink:MolecularActivity tetrahydrogeranylgeranyl-chlorophyll a reductase activity Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+. MetaCyc:RXN-7666 go.json http://purl.obolibrary.org/obo/GO_0102750 GO:0102753 biolink:MolecularActivity chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate = geranylgeranyl-chlorophyll b + diphosphoric acid. MetaCyc:RXN-7673 go.json http://purl.obolibrary.org/obo/GO_0102753 GO:0102752 biolink:MolecularActivity 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) Catalysis of the reaction: a glucosylated glycogenin = a glycogen. EC:2.4.1.18|MetaCyc:RXN-7669 go.json http://purl.obolibrary.org/obo/GO_0102752 GO:0102755 biolink:MolecularActivity gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide. MetaCyc:RXN-7680 go.json http://purl.obolibrary.org/obo/GO_0102755 GO:0102754 biolink:MolecularActivity chlorophyllide-b:phytyl-diphosphate phytyltransferase activity Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate = chlorophyll b + diphosphoric acid. MetaCyc:RXN-7674 go.json http://purl.obolibrary.org/obo/GO_0102754 GO:0102757 biolink:MolecularActivity NADPH phosphatase activity Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate. EC:3.1.3.108|MetaCyc:RXN-7703|RHEA:60664 go.json http://purl.obolibrary.org/obo/GO_0102757 GO:0102756 biolink:MolecularActivity obsolete very-long-chain 3-ketoacyl-CoA synthase activity OBSOLETE. Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA. go.json True http://purl.obolibrary.org/obo/GO_0102756 GO:0102759 biolink:MolecularActivity campestanol hydroxylase activity Catalysis of the reaction: H+ + campestanol + O2 + NADPH = 6-deoxycathasterone + H2O + NADP. MetaCyc:RXN-773 go.json http://purl.obolibrary.org/obo/GO_0102759 GO:0102758 biolink:MolecularActivity very-long-chain enoyl-CoA reductase activity Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH. This reaction is the fourth (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. EC:1.3.1.93|MetaCyc:RXN-7711|RHEA:14473 go.json http://purl.obolibrary.org/obo/GO_0102758 GO:0102760 biolink:MolecularActivity 6-deoxocathasterone hydroxylase activity Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor = 6-deoxoteasterone + H2O + an oxidized electron acceptor. MetaCyc:RXN-774 go.json http://purl.obolibrary.org/obo/GO_0102760 GO:0102762 biolink:MolecularActivity eriodictyol 4'-O-methyltransferase activity Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine. MetaCyc:RXN-7754 go.json http://purl.obolibrary.org/obo/GO_0102762 GO:0102761 biolink:MolecularActivity eriodictyol 3'-O-methyltransferase activity Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + homoeriodictyol + S-adenosyl-L-homocysteine. MetaCyc:RXN-7753|RHEA:60948 go.json http://purl.obolibrary.org/obo/GO_0102761 GO:0102764 biolink:MolecularActivity 6-deoxotyphasterol C-23 hydroxylase activity Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor. MetaCyc:RXN-777 go.json http://purl.obolibrary.org/obo/GO_0102764 GO:0102763 biolink:MolecularActivity phytyl-P kinase activity Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate. MetaCyc:RXN-7763|RHEA:38099 go.json http://purl.obolibrary.org/obo/GO_0102763 GO:0102766 biolink:MolecularActivity naringenin 7-O-methyltransferase activity Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine = sakuranetin + S-adenosyl-L-homocysteine + H+. EC:2.1.1.232|MetaCyc:RXN-7773|RHEA:31539 go.json http://purl.obolibrary.org/obo/GO_0102766 GO:0102765 biolink:MolecularActivity UDP-D-apiose synthase activity Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide. MetaCyc:RXN-7770 go.json http://purl.obolibrary.org/obo/GO_0102765 GO:0102768 biolink:MolecularActivity anthocyanidin synthase activity Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate. MetaCyc:RXN-7785 go.json http://purl.obolibrary.org/obo/GO_0102768 GO:0102767 biolink:MolecularActivity flavanone 4'-O-methyltransferase activity Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine. EC:2.1.1.231|MetaCyc:RXN-7777|RHEA:31743 go.json http://purl.obolibrary.org/obo/GO_0102767 GO:0102769 biolink:MolecularActivity dihydroceramide glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine. EC:2.4.1.80|MetaCyc:RXN-7793 go.json http://purl.obolibrary.org/obo/GO_0102769 GO:0102771 biolink:MolecularActivity sphingolipid very long chain fatty acid alpha-hydroxylase activity Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide. MetaCyc:RXN-7796|RHEA:46512 go.json http://purl.obolibrary.org/obo/GO_0102771 GO:0102770 biolink:MolecularActivity inositol phosphorylceramide synthase activity Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol. MetaCyc:RXN-7795 go.json http://purl.obolibrary.org/obo/GO_0102770 GO:0102773 biolink:MolecularActivity dihydroceramide kinase activity Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate. EC:2.7.1.138|MetaCyc:RXN-7799 go.json http://purl.obolibrary.org/obo/GO_0102773 GO:0102772 biolink:MolecularActivity sphingolipid C4-monooxygenase activity Catalysis of the reaction: a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O. EC:1.14.18.5|MetaCyc:RXN-14250|RHEA:55808 go.json sphingolipid long-chain base 4-hydroxylase activity http://purl.obolibrary.org/obo/GO_0102772 GO:0102775 biolink:MolecularActivity 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide. MetaCyc:RXN-7826 go.json http://purl.obolibrary.org/obo/GO_0102775 GO:0102774 biolink:MolecularActivity p-coumaroyltriacetic acid lactone synthase activity Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( = p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide. MetaCyc:RXN-7822 go.json http://purl.obolibrary.org/obo/GO_0102774 GO:0102777 biolink:MolecularActivity caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-). EC:2.3.1.153|MetaCyc:RXN-7842 go.json http://purl.obolibrary.org/obo/GO_0102777 GO:0102776 biolink:MolecularActivity UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+. MetaCyc:RXN-7828 go.json http://purl.obolibrary.org/obo/GO_0102776 GO:0102779 biolink:MolecularActivity cannabidiolate synthase activity Catalysis of the reaction: cannabigerolate + O2 = cannabidiolate + hydrogen peroxide. EC:1.21.3.8|MetaCyc:RXN-7855|RHEA:34411 go.json http://purl.obolibrary.org/obo/GO_0102779 GO:0102778 biolink:MolecularActivity delta9-tetrahydrocannabinolate synthase activity Catalysis of the reaction: cannabigerolate + O2 = delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide. EC:1.21.3.7|MetaCyc:RXN-7854|RHEA:34135 go.json http://purl.obolibrary.org/obo/GO_0102778 GO:0102780 biolink:MolecularActivity sitosterol hydroxylase activity Catalysis of the reaction: H+ + sitosterol + O2 + NADPH = (22alpha)-hydroxy-sitosterol + H2O + NADP. MetaCyc:RXN-7876 go.json http://purl.obolibrary.org/obo/GO_0102780 GO:0102782 biolink:MolecularActivity cholestanol hydroxylase activity Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP. MetaCyc:RXN-7878 go.json http://purl.obolibrary.org/obo/GO_0102782 GO:0102781 biolink:MolecularActivity isofucosterol hydroxylase activity Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH = (22alpha)-hydroxy-isofucosterol + H2O + NADP. MetaCyc:RXN-7877 go.json http://purl.obolibrary.org/obo/GO_0102781 GO:0102784 biolink:MolecularActivity lutein oxygenase activity Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. MetaCyc:RXN-7884 go.json http://purl.obolibrary.org/obo/GO_0102784 GO:0102783 biolink:MolecularActivity beta-carotene oxygenase activity Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. MetaCyc:RXN-7883 go.json http://purl.obolibrary.org/obo/GO_0102783 GO:0102786 biolink:MolecularActivity stearoyl-[acp] desaturase activity Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin. EC:1.14.19.2|MetaCyc:RXN-7903|RHEA:11776 go.json http://purl.obolibrary.org/obo/GO_0102786 GO:0102785 biolink:MolecularActivity violaxanthin oxygenase activity Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. MetaCyc:RXN-7886 go.json http://purl.obolibrary.org/obo/GO_0102785 GO:0102788 biolink:MolecularActivity 4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A. MetaCyc:RXN-7998 go.json http://purl.obolibrary.org/obo/GO_0102788 GO:0102787 biolink:MolecularActivity caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A. MetaCyc:RXN-7997 go.json http://purl.obolibrary.org/obo/GO_0102787 GO:0102789 biolink:MolecularActivity UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP. MetaCyc:RXN-8005 go.json http://purl.obolibrary.org/obo/GO_0102789 GO:0102711 biolink:MolecularActivity gibberellin A25,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 = gibberellin A13 + succinate + carbon dioxide. MetaCyc:RXN-6541 go.json http://purl.obolibrary.org/obo/GO_0102711 GO:0102710 biolink:MolecularActivity D-inositol-3-phosphate glycosyltransferase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+. EC:2.4.1.250|MetaCyc:RXN-6501|RHEA:26188 go.json http://purl.obolibrary.org/obo/GO_0102710 GO:0102713 biolink:MolecularActivity gibberellin A25 hydroxylase activity Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 = gibberellin A46 + succinate(2-) + carbon dioxide. MetaCyc:RXN-6543 go.json http://purl.obolibrary.org/obo/GO_0102713 GO:0102712 biolink:MolecularActivity gibberellin A13,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 = gibberellin A43 + succinate + carbon dioxide. MetaCyc:RXN-6542 go.json http://purl.obolibrary.org/obo/GO_0102712 GO:0102715 biolink:MolecularActivity gibberellin A17,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 = gibberellin A28 + succinate + carbon dioxide. MetaCyc:RXN-6546 go.json http://purl.obolibrary.org/obo/GO_0102715 GO:0102714 biolink:MolecularActivity gibberellin A12,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A14 + succinate + carbon dioxide. MetaCyc:RXN-6544 go.json http://purl.obolibrary.org/obo/GO_0102714 GO:0102717 biolink:MolecularActivity DIBOA-glucoside oxygenase activity Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate = TRIBOA-beta-D-glucoside + succinate + carbon dioxide. EC:1.14.11.59|MetaCyc:RXN-6685|RHEA:32115 go.json http://purl.obolibrary.org/obo/GO_0102717 GO:0102716 biolink:MolecularActivity gibberellin A28,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 = (2betaOH)-gibberellin28 + succinate + carbon dioxide. MetaCyc:RXN-6547 go.json http://purl.obolibrary.org/obo/GO_0102716 GO:0102719 biolink:MolecularActivity S-adenosyl-L-methionine:eugenol-O-methyltransferase activity Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine. EC:2.1.1.146|MetaCyc:RXN-6741 go.json http://purl.obolibrary.org/obo/GO_0102719 GO:0102718 biolink:MolecularActivity TRIBOA-glucoside methyltransferase activity Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine = (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+. EC:2.1.1.241|MetaCyc:RXN-6687|RHEA:32099 go.json http://purl.obolibrary.org/obo/GO_0102718 GO:0102720 biolink:MolecularActivity acetyl-coenzyme A:acetyl alcohol acetyltransferase activity Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A. EC:2.3.1.224|MetaCyc:RXN-6762|RHEA:36147 go.json http://purl.obolibrary.org/obo/GO_0102720 GO:0102722 biolink:MolecularActivity obsolete gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent OBSOLETE. Catalysis of the reaction: 4-hydroxybutyrate + NAD(P) = 4-oxobutanoate + H+ + NAD(P)H. MetaCyc:RXN-6903 go.json True http://purl.obolibrary.org/obo/GO_0102722 GO:0102721 biolink:MolecularActivity ubiquinol:oxygen oxidoreductase activity Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone. EC:1.10.3.11|MetaCyc:RXN-6883|RHEA:30255 go.json http://purl.obolibrary.org/obo/GO_0102721 GO:0102724 biolink:MolecularActivity UDP-glucose:curcumin monoglucoside glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP. MetaCyc:RXN-7063 go.json http://purl.obolibrary.org/obo/GO_0102724 GO:0102723 biolink:MolecularActivity UDP-glucose:curcumin glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+. MetaCyc:RXN-7062 go.json http://purl.obolibrary.org/obo/GO_0102723 GO:0102726 biolink:MolecularActivity DIMBOA glucoside beta-D-glucosidase activity Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose. EC:3.2.1.182|MetaCyc:RXN-7082|RHEA:33975 go.json http://purl.obolibrary.org/obo/GO_0102726 GO:0102725 biolink:MolecularActivity 24-methyldesmosterol reductase activity Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP. MetaCyc:RXN-708 go.json http://purl.obolibrary.org/obo/GO_0102725 GO:0102728 biolink:MolecularActivity campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH. MetaCyc:RXN-711|RHEA:54416 go.json http://purl.obolibrary.org/obo/GO_0102728 GO:0102727 biolink:MolecularActivity 3beta-hydroxysteroid dehydrogenase activity Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+. MetaCyc:RXN-710 go.json http://purl.obolibrary.org/obo/GO_0102727 GO:0102729 biolink:MolecularActivity 6-oxocampestanol hydroxylase activity Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP. MetaCyc:RXN-715 go.json http://purl.obolibrary.org/obo/GO_0102729 GO:0102731 biolink:MolecularActivity D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP. MetaCyc:RXN-7185 go.json http://purl.obolibrary.org/obo/GO_0102731 GO:0102730 biolink:MolecularActivity cathasterone hydroxylase activity Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor = teasterone + H2O + an oxidized electron acceptor. MetaCyc:RXN-716 go.json http://purl.obolibrary.org/obo/GO_0102730 GO:0102733 biolink:MolecularActivity typhasterol C-23 hydroxylase activity Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor. MetaCyc:RXN-719 go.json http://purl.obolibrary.org/obo/GO_0102733 GO:0102732 biolink:MolecularActivity myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP. EC:2.7.1.140|MetaCyc:RXN-7186 go.json http://purl.obolibrary.org/obo/GO_0102732 GO:0102735 biolink:MolecularActivity trihydroxybenzophenone synthase activity Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide. EC:2.3.1.220|MetaCyc:RXN-7481|RHEA:35143 go.json http://purl.obolibrary.org/obo/GO_0102735 GO:0102734 biolink:MolecularActivity brassinolide synthase activity Catalysis of the reaction: H+ + castasterone + NADPH + O2 = brassinolide + NADP + H2O. MetaCyc:RXN-720 go.json http://purl.obolibrary.org/obo/GO_0102734 GO:0102737 biolink:MolecularActivity p-coumaroyltriacetic acid synthase activity Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA = 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate. MetaCyc:RXN-7577 go.json http://purl.obolibrary.org/obo/GO_0102737 GO:0102739 biolink:MolecularActivity (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate = H+ + gibberellin A4 + succinate + 2 carbon dioxide. MetaCyc:RXN-7591 go.json http://purl.obolibrary.org/obo/GO_0102739 GO:0102738 biolink:MolecularActivity (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate = gibberellin A37 + carbon dioxide + succinate. MetaCyc:RXN-7589 go.json http://purl.obolibrary.org/obo/GO_0102738 GO:0102740 biolink:MolecularActivity theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity Catalysis of the reaction: theobromine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine. EC:2.1.1.160|MetaCyc:RXN-7599|RHEA:20944 go.json http://purl.obolibrary.org/obo/GO_0102740 GO:0102742 biolink:MolecularActivity R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH = (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP. EC:1.1.1.237|MetaCyc:RXN-7632 go.json http://purl.obolibrary.org/obo/GO_0102742 GO:0102741 biolink:MolecularActivity paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine. EC:2.1.1.160|MetaCyc:RXN-7601|RHEA:10280 go.json http://purl.obolibrary.org/obo/GO_0102741 GO:0102744 biolink:MolecularActivity all-trans-geranyl-geranyl diphosphate reductase activity Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP. MetaCyc:RXN-7658 go.json http://purl.obolibrary.org/obo/GO_0102744 GO:0102743 biolink:MolecularActivity eriodictyol,NADPH:oxygen oxidoreductase activity Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 = 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O. MetaCyc:RXN-7653 go.json http://purl.obolibrary.org/obo/GO_0102743 GO:0102746 biolink:MolecularActivity tetrahydrogeranylgeranyl-PP reductase activity Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP. MetaCyc:RXN-7660 go.json http://purl.obolibrary.org/obo/GO_0102746 GO:0102745 biolink:MolecularActivity dihydrogeranylgeranyl-PP reductase activity Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP. MetaCyc:RXN-7659 go.json http://purl.obolibrary.org/obo/GO_0102745 GO:0102748 biolink:MolecularActivity geranylgeranyl-chlorophyll a reductase activity Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP. MetaCyc:RXN-7664 go.json http://purl.obolibrary.org/obo/GO_0102748 GO:0102747 biolink:MolecularActivity chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) = geranylgeranyl-chlorophyll a + diphosphoric acid. MetaCyc:RXN-7663 go.json http://purl.obolibrary.org/obo/GO_0102747 GO:0102749 biolink:MolecularActivity dihydrogeranylgeranyl-chlorophyll a reductase activity Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP. MetaCyc:RXN-7665 go.json http://purl.obolibrary.org/obo/GO_0102749 GO:0102791 biolink:MolecularActivity sulfuretin synthase activity Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O. EC:1.21.3.6|MetaCyc:RXN-8008 go.json http://purl.obolibrary.org/obo/GO_0102791 GO:0102790 biolink:MolecularActivity cyanidin 5,3-O-glycosyltransferase activity Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP. MetaCyc:RXN-8006 go.json http://purl.obolibrary.org/obo/GO_0102790 GO:0102793 biolink:MolecularActivity soyasapogenol B glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B = H+ + UDP + soyasapogenol B 3-O-beta-glucuronate. EC:2.4.1.262|MetaCyc:RXN-8086|RHEA:31475 go.json http://purl.obolibrary.org/obo/GO_0102793 GO:0102792 biolink:MolecularActivity sinapaldehyde:NAD(P)+ oxidoreductase activity Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O = 2 H+ + trans-sinapate + NADPH. MetaCyc:RXN-8014 go.json http://purl.obolibrary.org/obo/GO_0102792 GO:0102795 biolink:MolecularActivity 1-naphthaldehyde:oxygen oxidoreductase activity Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide. EC:1.2.3.9|MetaCyc:RXN-8090 go.json http://purl.obolibrary.org/obo/GO_0102795 GO:0102794 biolink:MolecularActivity cinnamaldehyde:oxygen oxidoreductase activity Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide. EC:1.2.3.9|MetaCyc:RXN-8089 go.json http://purl.obolibrary.org/obo/GO_0102794 GO:0102797 biolink:MolecularActivity obsolete geranial:oxygen oxidoreductase activity OBSOLETE. Catalysis of the reaction: geranial + O2 + H2O = H+ + geranate + hydrogen peroxide. go.json True http://purl.obolibrary.org/obo/GO_0102797 GO:0102796 biolink:MolecularActivity protocatechualdehyde:oxygen oxidoreductase activity Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O = H+ + 3,4-dihydroxybenzoate + hydrogen peroxide. EC:1.2.3.9|MetaCyc:RXN-8091 go.json http://purl.obolibrary.org/obo/GO_0102796 GO:0102799 biolink:MolecularActivity glucosinolate glucohydrolase activity Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides. EC:3.2.1.147|MetaCyc:RXN-8134 go.json http://purl.obolibrary.org/obo/GO_0102799 GO:0102798 biolink:MolecularActivity obsolete heptaldehyde:oxygen oxidoreductase activity OBSOLETE. Catalysis of the reaction: heptanal + O2 + H2O = H+ + heptanoate + hydrogen peroxide. go.json True http://purl.obolibrary.org/obo/GO_0102798 GO:0004404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004404 GO:0004403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004403 GO:0004406 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004406 GO:0004405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004405 GO:0004400 biolink:MolecularActivity histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. EC:2.6.1.9|MetaCyc:HISTAMINOTRANS-RXN|RHEA:23744 go.json IAP transaminase activity|L-histidinol phosphate aminotransferase activity|L-histidinol-phosphate:2-oxoglutarate aminotransferase activity|glutamic-imidazoleacetol phosphate transaminase activity|histidine:imidazoleacetol phosphate transaminase activity|histidinol phosphate aminotransferase activity|histidinol-phosphate aminotransferase activity|imidazole acetol-phosphate transaminase activity|imidazoleacetol phosphate transaminase activity|imidazolylacetolphosphate aminotransferase activity|imidazolylacetolphosphate transaminase activity http://purl.obolibrary.org/obo/GO_0004400 GO:0004402 biolink:MolecularActivity histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. EC:2.3.1.48|MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN|RHEA:21992|Reactome:R-HSA-3301237|Reactome:R-HSA-3301345|Reactome:R-HSA-3318413|Reactome:R-HSA-3318415|Reactome:R-HSA-3318486|Reactome:R-HSA-3321805|Reactome:R-HSA-3321883|Reactome:R-HSA-3321975|Reactome:R-HSA-3451147|Reactome:R-HSA-3662318|Reactome:R-HSA-3662335|Reactome:R-HSA-3697008|Reactome:R-HSA-3697920|Reactome:R-HSA-5144542|Reactome:R-HSA-5250938 go.json H2A/H2B histone acetyltransferase activity|H3/H4 histone acetyltransferase activity|H4/H2 histone acetyltransferase activity|H4/H2A acetyltransferase activity|acetyl-CoA:histone acetyltransferase activity|histone acetokinase activity|histone acetylase activity|histone lysine acetyltransferase activity|histone transacetylase activity|nucleosome-histone acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004402 GO:0004401 biolink:MolecularActivity histidinol-phosphatase activity Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate. EC:3.1.3.15|KEGG_REACTION:R03013|MetaCyc:HISTIDPHOS-RXN|RHEA:14465 go.json HPpase activity|L-histidinol phosphate phosphatase activity|L-histidinol-phosphate phosphohydrolase activity|histidinol phosphate phosphatase activity|histidinolphosphatase activity|histidinolphosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0004401 GO:0004408 biolink:MolecularActivity holocytochrome-c synthase activity Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. EC:4.4.1.17|MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN|RHEA:22648 go.json cytochrome c heme-lyase activity|cytochrome c synthase activity|holocytochrome c synthetase activity|holocytochrome-c apocytochrome-c-lyase (heme-forming)|holocytochrome-c apocytochrome-c-lyase activity http://purl.obolibrary.org/obo/GO_0004408 GO:0004407 biolink:MolecularActivity histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. EC:3.5.1.98|MetaCyc:3.5.1.98-RXN|RHEA:58196|Reactome:R-HSA-2545203|Reactome:R-HSA-2545253|Reactome:R-HSA-3769447|Reactome:R-HSA-3777129|Reactome:R-HSA-3782637|Reactome:R-HSA-3782655|Reactome:R-HSA-427514|Reactome:R-HSA-433672|Reactome:R-HSA-6805650 go.json http://purl.obolibrary.org/obo/GO_0004407 GO:0004409 biolink:MolecularActivity homoaconitate hydratase activity Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O. EC:4.2.1.36|KEGG_REACTION:R04371|MetaCyc:HOMOACONITATE-HYDRATASE-RXN|RHEA:15485 go.json (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]|2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity|HACN activity|Lys4|LysF|cis-homoaconitase activity|homoaconitase activity http://purl.obolibrary.org/obo/GO_0004409 GO:0004415 biolink:MolecularActivity hyalurononglucosaminidase activity Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. EC:3.2.1.35|MetaCyc:3.2.1.35-RXN|Reactome:R-HSA-1793209|Reactome:R-HSA-2160874|Reactome:R-HSA-2160892|Reactome:R-HSA-2318585|Reactome:R-HSA-5693356|Reactome:R-HSA-9036077 go.json chondroitinase I activity|chondroitinase activity|hyaluronate 4-glycanohydrolase activity|hyaluronidase activity|hyaluronoglucosaminidase activity|hyaluronoglucosidase activity http://purl.obolibrary.org/obo/GO_0004415 GO:0004414 biolink:MolecularActivity homoserine O-acetyltransferase activity Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA. EC:2.3.1.31|KEGG_REACTION:R01776|MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN|RHEA:13701 go.json L-homoserine O-acetyltransferase activity|acetyl-CoA:L-homoserine O-acetyltransferase activity|homoserine O-trans-acetylase activity|homoserine acetyltransferase activity|homoserine transacetylase activity|homoserine-O-transacetylase activity http://purl.obolibrary.org/obo/GO_0004414 GO:0004417 biolink:MolecularActivity hydroxyethylthiazole kinase activity Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+. EC:2.7.1.50|KEGG_REACTION:R04448|MetaCyc:THIAZOLSYN3-RXN|RHEA:24212 go.json 4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity|ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity|hydroxyethylthiazole kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004417 GO:0004416 biolink:MolecularActivity hydroxyacylglutathione hydrolase activity Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. EC:3.1.2.6|MetaCyc:GLYOXII-RXN|RHEA:25245|Reactome:R-HSA-6783221 go.json S-(2-hydroxyacyl)glutathione hydrolase activity|S-2-hydroxylacylglutathione hydrolase activity|acetoacetylglutathione hydrolase activity|glyoxalase II activity http://purl.obolibrary.org/obo/GO_0004416 GO:0004411 biolink:MolecularActivity homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+. EC:1.13.11.5|KEGG_REACTION:R02519|MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN|RHEA:15449|Reactome:R-HSA-71164|UM-BBD_reactionID:r0105 go.json homogentisate dioxygenase activity|homogentisate oxidase activity|homogentisate oxygenase activity|homogentisate:oxygen 1,2-oxidoreductase (decyclizing)|homogentisic acid oxidase activity|homogentisic acid oxygenase activity|homogentisic oxygenase activity|homogentisicase activity http://purl.obolibrary.org/obo/GO_0004411 GO:0004410 biolink:MolecularActivity homocitrate synthase activity Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate. EC:2.3.3.14|KEGG_REACTION:R00271|MetaCyc:HOMOCITRATE-SYNTHASE-RXN|RHEA:12929 go.json 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity|2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)|acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)|acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity|homocitrate synthetase activity http://purl.obolibrary.org/obo/GO_0004410 GO:0004413 biolink:MolecularActivity homoserine kinase activity Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. EC:2.7.1.39|KEGG_REACTION:R01771|MetaCyc:HOMOSERKIN-RXN|RHEA:13985 go.json ATP:L-homoserine O-phosphotransferase activity|HSK|homoserine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004413 GO:0004412 biolink:MolecularActivity homoserine dehydrogenase activity Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. EC:1.1.1.3|MetaCyc:HOMOSERDEHYDROG-RXN|RHEA:15761 go.json http://purl.obolibrary.org/obo/GO_0004412 GO:0004419 biolink:MolecularActivity hydroxymethylglutaryl-CoA lyase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. EC:4.1.3.4|KEGG_REACTION:R01360|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN|RHEA:24404|Reactome:R-HSA-6788597|Reactome:R-HSA-74180 go.json (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)|(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity|3-hydroxy-3-methylglutarate-CoA lyase activity|3-hydroxy-3-methylglutaryl CoA cleaving enzyme|3-hydroxy-3-methylglutaryl coenzyme A lyase activity|3-hydroxy-3-methylglutaryl-CoA lyase activity|HMG-CoA lyase activity|hydroxymethylglutaryl coenzyme A lyase activity|hydroxymethylglutaryl coenzyme A-cleaving enzyme http://purl.obolibrary.org/obo/GO_0004419 GO:0004418 biolink:MolecularActivity hydroxymethylbilane synthase activity Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. EC:2.5.1.61|KEGG_REACTION:R00084|MetaCyc:OHMETHYLBILANESYN-RXN|RHEA:13185|Reactome:R-HSA-189406 go.json (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity|(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)|HMB-synthase activity|porphobilinogen ammonia-lyase (polymerizing)|porphobilinogen deaminase activity|porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)|pre-uroporphyrinogen synthase activity|uroporphyrinogen I synthase activity|uroporphyrinogen I synthetase activity|uroporphyrinogen synthase activity|uroporphyrinogen synthetase activity http://purl.obolibrary.org/obo/GO_0004418 GO:0004488 biolink:MolecularActivity methylenetetrahydrofolate dehydrogenase (NADP+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. EC:1.5.1.5|KEGG_REACTION:R01220|MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN|RHEA:22812 go.json 5,10-methylenetetrahydrofolate:NADP oxidoreductase activity|5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004488 GO:0004487 biolink:MolecularActivity methylenetetrahydrofolate dehydrogenase (NAD+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH. EC:1.5.1.15|KEGG_REACTION:R01218|MetaCyc:1.5.1.15-RXN|RHEA:22892|Reactome:R-HSA-6801462 go.json 5,10-methylenetetrahydrofolate dehydrogenase activity|5,10-methylenetetrahydrofolate:NAD+ oxidoreductase http://purl.obolibrary.org/obo/GO_0004487 GO:0004489 biolink:MolecularActivity methylenetetrahydrofolate reductase (NAD(P)H) activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. EC:1.5.1.20|KEGG_REACTION:R01224|KEGG_REACTION:R07168|MetaCyc:1.5.1.20-RXN|Reactome:R-HSA-200676 go.json 5,10-CH(2)-H(4)folate reductase activity|5,10-CH2-H4folate reductase activity|5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|5,10-methylenetetrahydrofolate reductase (FADH) activity|5,10-methylenetetrahydrofolate reductase (FADH2) activity|5,10-methylenetetrahydrofolate reductase (NADPH) activity|5,10-methylenetetrahydrofolate reductase activity|5,10-methylenetetrahydrofolic acid reductase activity|5,10-methylenetetrahydropteroylglutamate reductase activity|5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|5-methyltetrahydrofolate:NAD oxidoreductase activity|5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|5-methyltetrahydrofolate:NAD+ oxidoreductase activity|5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|5-methyltetrahydrofolate:NADP+ oxidoreductase activity|MTHFR activity|MetF|N(5),N(10)-methylenetetrahydrofolate reductase activity|N(5,10)-methylenetetrahydrofolate reductase activity|N5,10-methylenetetrahydrofolate reductase activity|N5,N10-methylenetetrahydrofolate reductase activity|methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|methylenetetrahydrofolate reductase (NADPH(2)) activity|methylenetetrahydrofolate reductase (NADPH2)|methylenetetrahydrofolate reductase [NAD(P)H]|methylenetetrahydrofolate reductase activity|methylenetetrahydrofolic acid reductase activity http://purl.obolibrary.org/obo/GO_0004489 GO:0004484 biolink:MolecularActivity mRNA guanylyltransferase activity Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. EC:2.7.7.50|MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN|RHEA:54592|Reactome:R-HSA-77081|Reactome:R-HSA-77083|Reactome:R-HSA-9815529 go.json GTP--RNA guanylyltransferase activity|GTP:mRNA guanylyltransferase activity|mRNA capping enzyme activity|messenger RNA guanylyltransferase activity|protein lambda2 http://purl.obolibrary.org/obo/GO_0004484 GO:0004483 biolink:MolecularActivity mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. EC:2.1.1.57|MetaCyc:2.1.1.57-RXN|Reactome:R-HSA-9684030|Reactome:R-HSA-9684032|Reactome:R-HSA-9684033|Reactome:R-HSA-9694499|Reactome:R-HSA-9694521|Reactome:R-HSA-9694721 go.json S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity|mRNA (adenosine-2'-O-)-methyltransferase activity|messenger RNA (nucleoside-2'-)-methyltransferase activity|messenger ribonucleate nucleoside 2'-methyltransferase activity http://purl.obolibrary.org/obo/GO_0004483 GO:0004486 biolink:MolecularActivity methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. EC:1.5.1.5|Reactome:R-HSA-200644|Reactome:R-HSA-200718 go.json 5,10-methylene-THF dehydrogenase activity|N5,N10-methylenetetrahydrofolate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004486 GO:0004485 biolink:MolecularActivity methylcrotonoyl-CoA carboxylase activity Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate. EC:6.4.1.4|KEGG_REACTION:R04138|MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN|RHEA:13589|Reactome:R-HSA-508308|Reactome:R-HSA-70773 go.json 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)|MCCC activity|beta-methylcrotonyl CoA carboxylase activity|beta-methylcrotonyl coenzyme A carboxylase activity|beta-methylcrotonyl-CoA carboxylase activity|methylcrotonyl coenzyme A carboxylase activity|methylcrotonyl-CoA carboxylase activity http://purl.obolibrary.org/obo/GO_0004485 GO:0004480 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004480 GO:0004482 biolink:MolecularActivity mRNA 5'-cap (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. EC:2.1.1.56|MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN|Reactome:R-HSA-77090|Reactome:R-HSA-9684016|Reactome:R-HSA-9684017|Reactome:R-HSA-9684018|Reactome:R-HSA-9694476|Reactome:R-HSA-9694492|Reactome:R-HSA-9694737 go.json S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity|S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity|guanine-7-methyltransferase activity|messenger RNA guanine 7-methyltransferase activity|messenger ribonucleate guanine 7-methyltransferase activity http://purl.obolibrary.org/obo/GO_0004482 GO:0004481 biolink:MolecularActivity methylene-fatty-acyl-phospholipid synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. EC:2.1.1.16|MetaCyc:2.1.1.16-RXN|RHEA:17549 go.json S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)|cyclopropane synthetase activity|unsaturated-phospholipid methyltransferase activity http://purl.obolibrary.org/obo/GO_0004481 GO:0004499 biolink:MolecularActivity N,N-dimethylaniline monooxygenase activity Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. EC:1.14.13.8|MetaCyc:1.14.13.8-RXN|RHEA:24468|Reactome:R-HSA-139970|Reactome:R-HSA-217255|Reactome:R-HSA-5602966 go.json 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity|DMA oxidase activity|FAD-containing monooxygenase activity|FMO activity|FMO-I|FMO-II|FMO1|FMO2|FMO3|FMO4|FMO5|N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)|Ziegler's enzyme|dimethylaniline N-oxidase activity|dimethylaniline monooxygenase (N-oxide-forming) activity|dimethylaniline oxidase activity|flavin mixed function oxidase activity|flavin monooxygenase activity|flavin-containing monooxygenase activity|methylphenyltetrahydropyridine N-monooxygenase activity|mixed-function amine oxidase activity http://purl.obolibrary.org/obo/GO_0004499 GO:0004498 biolink:MolecularActivity calcidiol 1-monooxygenase activity Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+. EC:1.14.15.18|KEGG_REACTION:R03610|MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN|RHEA:20573|Reactome:R-HSA-209868|Reactome:R-HSA-5602186 go.json 1-hydroxylase-25-hydroxyvitamin D3 activity|25-OHD-1 alpha-hydroxylase activity|25-hydroxy D3-1alpha-hydroxylase activity|25-hydroxy vitamin D3 1-alpha-hydroxylase activity|25-hydroxycholecalciferol 1-hydroxylase activity|25-hydroxycholecalciferol 1-monooxygenase activity|25-hydroxycholecalciferol 1alpha-hydroxylase activity|25-hydroxycholecalciferol-1-hydroxylase activity|25-hydroxyvitamin D-1 alpha hydroxylase activity|25-hydroxyvitamin D3 1alpha-hydroxylase activity|calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)|cytochrome P450 CYP27B http://purl.obolibrary.org/obo/GO_0004498 GO:0004495 biolink:MolecularActivity mevaldate reductase activity Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor. go.json http://purl.obolibrary.org/obo/GO_0004495 GO:0004494 biolink:MolecularActivity methylmalonyl-CoA mutase activity Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. EC:5.4.99.2|KEGG_REACTION:R00833|MetaCyc:METHYLMALONYL-COA-MUT-RXN|RHEA:22888|Reactome:R-HSA-3322971|Reactome:R-HSA-71010|UM-BBD_reactionID:r0922 go.json (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity|(R)-methylmalonyl-CoA CoA-carbonylmutase activity|(S)-methylmalonyl-CoA mutase activity|methylmalonyl coenzyme A carbonylmutase activity|methylmalonyl coenzyme A mutase activity|methylmalonyl-CoA CoA-carbonyl mutase activity http://purl.obolibrary.org/obo/GO_0004494 GO:0004497 biolink:MolecularActivity monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Reactome:R-HSA-143468|Reactome:R-HSA-156526|Reactome:R-HSA-211882|Reactome:R-HSA-211904|Reactome:R-HSA-211910|Reactome:R-HSA-211919|Reactome:R-HSA-211924|Reactome:R-HSA-211929|Reactome:R-HSA-211948|Reactome:R-HSA-211951|Reactome:R-HSA-211959|Reactome:R-HSA-211960|Reactome:R-HSA-211962|Reactome:R-HSA-211968|Reactome:R-HSA-211988|Reactome:R-HSA-211991|Reactome:R-HSA-212004|Reactome:R-HSA-212005|Reactome:R-HSA-213175|Reactome:R-HSA-215526|Reactome:R-HSA-2161795|Reactome:R-HSA-2161814|Reactome:R-HSA-2161890|Reactome:R-HSA-2161899|Reactome:R-HSA-2161940|Reactome:R-HSA-2162191|Reactome:R-HSA-217258|Reactome:R-HSA-5423647|Reactome:R-HSA-5423664|Reactome:R-HSA-5423672|Reactome:R-HSA-5423678|Reactome:R-HSA-5602242|Reactome:R-HSA-5602272|Reactome:R-HSA-5602295|Reactome:R-HSA-5605147|Reactome:R-HSA-5662662|Reactome:R-HSA-5662692|Reactome:R-HSA-5663050|Reactome:R-HSA-6786239|Reactome:R-HSA-76354|Reactome:R-HSA-76373|Reactome:R-HSA-76386|Reactome:R-HSA-76397|Reactome:R-HSA-76416|Reactome:R-HSA-76426|Reactome:R-HSA-76434|Reactome:R-HSA-76456|Reactome:R-HSA-76466|Reactome:R-HSA-76472|Reactome:R-HSA-76475|Reactome:R-HSA-8865107|Reactome:R-HSA-9018874|Reactome:R-HSA-9027042|Reactome:R-HSA-9027043|Reactome:R-HSA-9027044|Reactome:R-HSA-9027302|Reactome:R-HSA-9027321|Reactome:R-HSA-9037761|Reactome:R-HSA-9749986|Reactome:R-HSA-9750016|Reactome:R-HSA-9753285|Reactome:R-HSA-9756138|Reactome:R-HSA-9756162|Reactome:R-HSA-9756169|Reactome:R-HSA-9756180 go.json hydroxylase activity http://purl.obolibrary.org/obo/GO_0004497 goslim_pir GO:0004496 biolink:MolecularActivity mevalonate kinase activity Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+. EC:2.7.1.36|KEGG_REACTION:R02245|MetaCyc:MEVALONATE-KINASE-RXN|RHEA:17065|Reactome:R-HSA-191380 go.json ATP:(R)-mevalonate 5-phosphotransferase activity|ATP:mevalonate 5-phosphotransferase activity|MVA kinase activity|mevalonate 5-phosphotransferase activity|mevalonate kinase (phosphorylating)|mevalonate phosphokinase activity|mevalonic acid kinase activity|mevalonic kinase activity http://purl.obolibrary.org/obo/GO_0004496 GO:0004491 biolink:MolecularActivity methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. EC:1.2.1.27|MetaCyc:1.2.1.27-RXN|Reactome:R-HSA-70893 go.json MMSA dehydrogenase activity|MSDH activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity http://purl.obolibrary.org/obo/GO_0004491 GO:0004490 biolink:MolecularActivity methylglutaconyl-CoA hydratase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O. EC:4.2.1.18|KEGG_REACTION:R02085|MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN|RHEA:21536|Reactome:R-HSA-70785 go.json (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)|(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity|3-methylglutaconyl CoA hydratase activity|methylglutaconase activity|methylglutaconyl coenzyme A hydratase activity http://purl.obolibrary.org/obo/GO_0004490 GO:0004493 biolink:MolecularActivity methylmalonyl-CoA epimerase activity Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. EC:5.1.99.1|KEGG_REACTION:R02765|MetaCyc:METHYLMALONYL-COA-EPIM-RXN|RHEA:20553|Reactome:R-HSA-71020 go.json 2-methyl-3-oxopropanoyl-CoA 2-epimerase activity|DL-methylmalonyl-CoA racemase activity|methylmalonyl coenzyme A racemase activity|methylmalonyl-CoA 2-epimerase activity|methylmalonyl-CoA racemase activity http://purl.obolibrary.org/obo/GO_0004493 GO:0102801 biolink:MolecularActivity anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A. EC:2.3.1.214|MetaCyc:RXN-8139|RHEA:35515 go.json http://purl.obolibrary.org/obo/GO_0102801 GO:0004492 biolink:MolecularActivity methyl/ethyl malonyl-CoA decarboxylase activity Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2. MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN go.json (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity|(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)|(S)-methylmalonyl-CoA carboxy-lyase activity|ethylmalonyl-CoA decarboxylase activity|methylmalonyl-coenzyme A decarboxylase activity http://purl.obolibrary.org/obo/GO_0004492 GO:0102800 biolink:MolecularActivity caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A. MetaCyc:RXN-8138 go.json http://purl.obolibrary.org/obo/GO_0102800 GO:0102803 biolink:MolecularActivity thebane O-demethylase activity Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = oripavine + formaldehyde + succinate + carbon dioxide. EC:1.14.11.32|MetaCyc:RXN-8149 go.json http://purl.obolibrary.org/obo/GO_0102803 GO:0102802 biolink:MolecularActivity thebaine 6-O-demethylase activity Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + carbon dioxide. EC:1.14.11.31|MetaCyc:RXN-8147|RHEA:27477 go.json http://purl.obolibrary.org/obo/GO_0102802 GO:0102805 biolink:MolecularActivity codeine O-demethylase activity Catalysis of the reaction: codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + carbon dioxide. EC:1.14.11.32|MetaCyc:RXN-8152|RHEA:27413 go.json http://purl.obolibrary.org/obo/GO_0102805 GO:0102804 biolink:MolecularActivity oripavine 6-O-demethylase activity Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 = morphinone + formaldehyde + succinate + carbon dioxide. EC:1.14.11.31|MetaCyc:RXN-8151 go.json http://purl.obolibrary.org/obo/GO_0102804 GO:0102807 biolink:MolecularActivity cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-O-sophoroside + UDP + H+. MetaCyc:RXN-8176 go.json http://purl.obolibrary.org/obo/GO_0102807 GO:0102806 biolink:MolecularActivity 4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine = shisonin + coenzyme A. MetaCyc:RXN-8170 go.json http://purl.obolibrary.org/obo/GO_0102806 GO:0102809 biolink:MolecularActivity delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside = H+ + delphinidin 3-O-sophoroside + UDP. MetaCyc:RXN-8178 go.json http://purl.obolibrary.org/obo/GO_0102809 GO:0102808 biolink:MolecularActivity pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside = H+ + pelargonidin 3-O-sophoroside + UDP. MetaCyc:RXN-8177 go.json http://purl.obolibrary.org/obo/GO_0102808 GO:0004469 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004469 GO:0004466 biolink:MolecularActivity long-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. EC:1.3.8.8|MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN|RHEA:17721 go.json long-chain acyl-coenzyme A dehydrogenase activity|palmitoyl-CoA dehydrogenase activity|palmitoyl-coenzyme A dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004466 GO:0004465 biolink:MolecularActivity lipoprotein lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. EC:3.1.1.34|Reactome:R-HSA-1482811|Reactome:R-HSA-174757|Reactome:R-HSA-2395768|Reactome:R-HSA-6789310|Reactome:R-HSA-8979996|Reactome:R-HSA-8980228 go.json clearing factor lipase activity|diacylglycerol hydrolase activity|diacylglycerol lipase activity|diglyceride lipase activity|lipemia-clearing factor|postheparin esterase activity|postheparin lipase activity|triacylglycero-protein acylhydrolase activity http://purl.obolibrary.org/obo/GO_0004465 GO:0004468 biolink:MolecularActivity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. EC:2.3.1.32|MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN|RHEA:14417|Reactome:R-HSA-5618328|Reactome:R-HSA-5693001 go.json LAT activity|acetyl-phosphate:L-lysine 6-N-acetyltransferase activity|acetyl-phosphate:L-lysine N6-acetyltransferase activity|lysine N(6)-acetyltransferase activity|lysine N6-acetyltransferase activity|lysine acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004468 GO:0004467 biolink:MolecularActivity long-chain fatty acid-CoA ligase activity Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. EC:6.2.1.3|MetaCyc:PWY-5143|MetaCyc:RXN-7904|RHEA:15421|Reactome:R-HSA-159425|Reactome:R-HSA-192137|Reactome:R-HSA-193401|Reactome:R-HSA-193407|Reactome:R-HSA-193424|Reactome:R-HSA-193711|Reactome:R-HSA-193727|Reactome:R-HSA-193743|Reactome:R-HSA-193766|Reactome:R-HSA-201035|Reactome:R-HSA-2046085|Reactome:R-HSA-2046098|Reactome:R-HSA-548843|Reactome:R-HSA-5696004|Reactome:R-HSA-9734535|UM-BBD_enzymeID:e0025 go.json LCFA synthetase activity|acyl-CoA ligase activity|acyl-CoA synthetase activity|acyl-activating enzyme activity|fatty acid thiokinase (long-chain) activity|lignoceroyl-CoA synthase activity|long chain fatty acyl-CoA synthetase activity|long-chain acyl CoA synthetase activity|long-chain acyl-CoA synthetase activity|long-chain acyl-coenzyme A synthetase activity|long-chain fatty acid activation|long-chain fatty acyl coenzyme A synthetase activity|long-chain-fatty-acid-CoA ligase activity|long-chain-fatty-acyl-CoA synthetase activity|pristanoyl-CoA synthetase|stearoyl-CoA synthetase|thiokinase http://purl.obolibrary.org/obo/GO_0004467 GO:0004462 biolink:MolecularActivity lactoylglutathione lyase activity Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. EC:4.4.1.5|KEGG_REACTION:R02530|MetaCyc:GLYOXI-RXN|RHEA:19069|Reactome:R-HSA-5694071 go.json (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity|(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)|aldoketomutase activity|glyoxalase I activity|glyoxylase I|ketone-aldehyde mutase activity|methylglyoxalase activity http://purl.obolibrary.org/obo/GO_0004462 GO:0004461 biolink:MolecularActivity lactose synthase activity Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. EC:2.4.1.22|MetaCyc:LACTOSE-SYNTHASE-RXN|RHEA:12404|Reactome:R-HSA-5653878 go.json UDP-galactose-glucose galactosyltransferase activity|UDP-galactose:D-glucose 4-beta-D-galactotransferase activity|UDPgalactose-glucose galactosyltransferase activity|UDPgalactose:D-glucose 4-beta-D-galactotransferase activity|lactose synthetase activity|uridine diphosphogalactose-glucose galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0004461 GO:0004464 biolink:MolecularActivity leukotriene-C4 synthase activity Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). EC:4.4.1.20|KEGG_REACTION:R03059|MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN|RHEA:17617|Reactome:R-HSA-266050 go.json (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)|(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)|LTC(4) synthase activity|LTC(4) synthetase activity|LTC4 synthase activity|LTC4 synthetase activity|leukotriene A(4):glutathione S-leukotrienyltransferase activity|leukotriene A4:glutathione S-leukotrienyltransferase activity|leukotriene C(4) synthetase activity|leukotriene C4 synthetase activity|leukotriene-C4 glutathione-lyase (leukotriene-A4-forming) http://purl.obolibrary.org/obo/GO_0004464 GO:0004463 biolink:MolecularActivity leukotriene-A4 hydrolase activity Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4). EC:3.3.2.6|KEGG_REACTION:R03057|MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN|RHEA:22324|Reactome:R-HSA-266072 go.json (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity|LTA-4 hydrolase activity|LTA4 hydrolase activity|LTA4H|leukotriene A(4) hydrolase activity|leukotriene A4 hydrolase activity http://purl.obolibrary.org/obo/GO_0004463 GO:0102810 biolink:MolecularActivity glutarate-semialdehyde dehydrogenase (NADP+) activity Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+. EC:1.2.1.20|MetaCyc:RXN-8182|RHEA:57832 go.json http://purl.obolibrary.org/obo/GO_0102810 GO:0004460 biolink:MolecularActivity L-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. EC:1.1.2.3|MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:19909 go.json (S)-lactate:ferricytochrome-c 2-oxidoreductase activity|L(+)-lactate:cytochrome c oxidoreductase activity|L-lactate cytochrome c oxidoreductase activity|L-lactate cytochrome c reductase activity|L-lactate ferricytochrome c oxidoreductase activity|cytochrome b2|cytochrome b2 (flavin-free derivative of flavocytochrome b2)|dehydrogenase, lactate (cytochrome)|flavocytochrome b2|lactate dehydrogenase (cytochrome)|lactic acid dehydrogenase activity|lactic cytochrome c reductase activity http://purl.obolibrary.org/obo/GO_0004460 GO:0102812 biolink:MolecularActivity 4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A. MetaCyc:RXN-8204 go.json http://purl.obolibrary.org/obo/GO_0102812 GO:0102811 biolink:MolecularActivity geraniol 10-hydroxylase activity Catalysis of the reaction: geraniol + O2 + NADPH + H+ = (6E)-8-hydroxygeraniol + NADP + H2O. EC:1.14.14.83|MetaCyc:RXN-8197|RHEA:32495 go.json http://purl.obolibrary.org/obo/GO_0102811 GO:0102814 biolink:MolecularActivity caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A. MetaCyc:RXN-8232 go.json http://purl.obolibrary.org/obo/GO_0102814 GO:0102813 biolink:MolecularActivity UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+. MetaCyc:RXN-8205 go.json http://purl.obolibrary.org/obo/GO_0102813 GO:0102816 biolink:MolecularActivity UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside = H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP. EC:2.4.1.298|MetaCyc:RXN-8234|RHEA:35423 go.json http://purl.obolibrary.org/obo/GO_0102816 GO:0102815 biolink:MolecularActivity caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A. EC:2.3.1.153|MetaCyc:RXN-8233 go.json http://purl.obolibrary.org/obo/GO_0102815 GO:0102818 biolink:MolecularActivity lycopene cleavage oxygenase activity Catalysis of the reaction: lycopene + 2 O2 = 2 sulcatone + bixin aldehyde. MetaCyc:RXN-8236 go.json http://purl.obolibrary.org/obo/GO_0102818 GO:0102817 biolink:MolecularActivity caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA = gentiodelphin + coenzyme A. MetaCyc:RXN-8235 go.json http://purl.obolibrary.org/obo/GO_0102817 GO:0102819 biolink:MolecularActivity bixin aldehyde dehydrogenase activity Catalysis of the reaction: bixin aldehyde + O2 + NAD = norbixin + NADH + H+. MetaCyc:RXN-8237 go.json http://purl.obolibrary.org/obo/GO_0102819 GO:0004477 biolink:MolecularActivity methenyltetrahydrofolate cyclohydrolase activity Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. EC:3.5.4.9|MetaCyc:METHENYLTHFCYCLOHYDRO-RXN|RHEA:23700|Reactome:R-HSA-200661|Reactome:R-HSA-200740|Reactome:R-HSA-6801328 go.json 5,10-methenyl-THF cyclohydrolase activity|5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)|citrovorum factor cyclodehydrase activity|formyl-methenyl-methylenetetrahydrofolate synthetase (combined) http://purl.obolibrary.org/obo/GO_0004477 GO:0004476 biolink:MolecularActivity mannose-6-phosphate isomerase activity Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. EC:5.3.1.8|MetaCyc:MANNPISOM-RXN|RHEA:12356|Reactome:R-HSA-3781832|Reactome:R-HSA-532549 go.json D-mannose-6-phosphate aldose-ketose-isomerase activity|D-mannose-6-phosphate ketol-isomerase activity|mannose phosphate isomerase activity|phosphohexoisomerase activity|phosphohexomutase activity|phosphomannoisomerase activity|phosphomannose isomerase activity http://purl.obolibrary.org/obo/GO_0004476 GO:0004479 biolink:MolecularActivity methionyl-tRNA formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. EC:2.1.2.9|MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN|RHEA:24380|Reactome:R-HSA-5389841 go.json 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity|N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity|N-terminal peptidyl-methionine N-formylation|N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity|conversion of met-tRNAf to fmet-tRNA|conversion of mitochondrial met-tRNAf to fmet-tRNA|formylmethionyl-transfer ribonucleic synthetase activity|methionyl ribonucleic formyltransferase activity|methionyl-tRNA Met formyltransferase activity|methionyl-tRNA transformylase activity|methionyl-transfer RNA transformylase activity|methionyl-transfer ribonucleate methyltransferase activity|methionyl-transfer ribonucleic transformylase activity|mitochondrial N-terminal peptidyl-methionine N-formylation http://purl.obolibrary.org/obo/GO_0004479 GO:0004478 biolink:MolecularActivity methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. EC:2.5.1.6|MetaCyc:S-ADENMETSYN-RXN|RHEA:21080|Reactome:R-HSA-174391|Reactome:R-HSA-5603087|Reactome:R-HSA-5603114 go.json ATP-methionine adenosyltransferase activity|ATP:L-methionine S-adenosyltransferase activity|AdoMet synthetase activity|S-adenosyl-L-methionine synthetase activity|S-adenosylmethionine synthase activity|S-adenosylmethionine synthetase activity|adenosylmethionine synthetase activity|methionine S-adenosyltransferase activity|methionine-activating enzyme http://purl.obolibrary.org/obo/GO_0004478 GO:0004473 biolink:MolecularActivity malate dehydrogenase (decarboxylating) (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. EC:1.1.1.40|KEGG_REACTION:R00216|MetaCyc:MALIC-NADP-RXN|RHEA:18253|Reactome:R-HSA-9012036|Reactome:R-HSA-9012349 go.json 'malic' enzyme|(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|L-malate:NADP oxidoreductase activity|NADP-linked decarboxylating malic enzyme|NADP-malic enzyme activity|NADP-specific malate dehydrogenase activity|NADP-specific malic enzyme|malate dehydrogenase (NADP, decarboxylating)|malate dehydrogenase (decarboxylating, NADP) http://purl.obolibrary.org/obo/GO_0004473 GO:0004472 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004472 GO:0004475 biolink:MolecularActivity mannose-1-phosphate guanylyltransferase (GTP) activity Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. EC:2.7.7.13|KEGG_REACTION:R00885|MetaCyc:2.7.7.13-RXN|RHEA:15229|Reactome:R-HSA-446221 go.json GDP-mannose pyrophosphorylase activity|GTP-mannose-1-phosphate guanylyltransferase activity|GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity|GTP:mannose-1-phosphate guanylyltransferase activity|PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)|guanosine 5'-diphospho-D-mannose pyrophosphorylase activity|guanosine diphosphomannose pyrophosphorylase activity|guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity|mannose 1-phosphate guanylyltransferase (guanosine triphosphate)|mannose-1-phosphate guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0004475 GO:0004474 biolink:MolecularActivity malate synthase activity Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+. EC:2.3.3.9|KEGG_REACTION:R00472|MetaCyc:MALSYN-RXN|RHEA:18181 go.json L-malate glyoxylate-lyase (CoA-acetylating) activity|acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|glyoxylate transacetase activity|glyoxylate transacetylase activity|glyoxylic transacetase activity|malate condensing enzyme activity|malate synthetase activity|malic synthetase activity|malic-condensing enzyme activity http://purl.obolibrary.org/obo/GO_0004474 GO:0102821 biolink:MolecularActivity bixin methyltransferase activity Catalysis of the reaction: bixin + S-adenosyl-L-methionine = bixin dimethyl ester + S-adenosyl-L-homocysteine. MetaCyc:RXN-8239 go.json http://purl.obolibrary.org/obo/GO_0102821 GO:0102820 biolink:MolecularActivity norbixin methyltransferase activity Catalysis of the reaction: norbixin + S-adenosyl-L-methionine = bixin + S-adenosyl-L-homocysteine. MetaCyc:RXN-8238 go.json http://purl.obolibrary.org/obo/GO_0102820 GO:0102823 biolink:MolecularActivity kaempferol-3-rhamnoside-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside = kaempferol 3-O-rhamnoside-7-O-glucoside + UDP. MetaCyc:RXN-8266 go.json http://purl.obolibrary.org/obo/GO_0102823 GO:0004471 biolink:MolecularActivity malate dehydrogenase (decarboxylating) (NAD+) activity Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. EC:1.1.1.38|EC:1.1.1.39|KEGG_REACTION:R00214|MetaCyc:1.1.1.39-RXN|RHEA:12653|Reactome:R-HSA-9012268 go.json 'malic' enzyme|(S)-malate:NAD+ oxidoreductase (decarboxylating)|(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)|NAD-linked malic enzyme|NAD-malic enzyme activity|NAD-specific malic enzyme|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity http://purl.obolibrary.org/obo/GO_0004471 GO:0004470 biolink:MolecularActivity malic enzyme activity Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. go.json pyruvic-malic carboxylase activity http://purl.obolibrary.org/obo/GO_0004470 GO:0102822 biolink:MolecularActivity quercetin 3'-O-methyltransferase activity Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine. EC:2.1.1.42|MetaCyc:RXN-8262|RHEA:55332 go.json http://purl.obolibrary.org/obo/GO_0102822 GO:0102825 biolink:MolecularActivity quercetin 3-O-rhamnoside-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside = quercetin 3-O-rhamnoside-7-O-glucoside + UDP. MetaCyc:RXN-8268 go.json http://purl.obolibrary.org/obo/GO_0102825 GO:0102824 biolink:MolecularActivity UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose = H+ + quercetin 3-O-rhamnoside + UDP. MetaCyc:RXN-8267|RHEA:61160 go.json http://purl.obolibrary.org/obo/GO_0102824 GO:0102827 biolink:MolecularActivity galactosylononitol-raffinose galactosyltransferase activity Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol. MetaCyc:RXN-8282 go.json http://purl.obolibrary.org/obo/GO_0102827 GO:0102826 biolink:MolecularActivity kaempferol-3-glucoside-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside = kaempferol 3,7-O-diglucoside + UDP. MetaCyc:RXN-8270 go.json http://purl.obolibrary.org/obo/GO_0102826 GO:0102829 biolink:MolecularActivity ajugose synthase activity Catalysis of the reaction: 2 verbascose = ajugose + stachyose. MetaCyc:RXN-8285 go.json http://purl.obolibrary.org/obo/GO_0102829 GO:0102828 biolink:MolecularActivity stachyose galactinol:verbascose galactosyltransferase activity Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = verbascose + myo-inositol. MetaCyc:RXN-8284 go.json http://purl.obolibrary.org/obo/GO_0102828 GO:0004448 biolink:MolecularActivity isocitrate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H. go.json IDH activity|IDP activity|isocitrate dehydrogenase activity|isocitric acid dehydrogenase activity|isocitric dehydrogenase activity|oxalosuccinate carboxylase activity|oxalosuccinate decarboxylase activity|oxalosuccinic decarboxylase activity http://purl.obolibrary.org/obo/GO_0004448 gocheck_do_not_annotate GO:0004447 biolink:MolecularActivity iodide peroxidase activity Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O. EC:1.11.1.8|MetaCyc:IODIDE-PEROXIDASE-RXN go.json TPO activity|iodinase activity|thyroid peroxidase activity|thyroperoxidase activity http://purl.obolibrary.org/obo/GO_0004447 GO:0004449 biolink:MolecularActivity isocitrate dehydrogenase (NAD+) activity Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. EC:1.1.1.41|MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN|RHEA:23632|Reactome:R-HSA-70967 go.json NAD dependent isocitrate dehydrogenase activity|NAD isocitrate dehydrogenase activity|NAD isocitric dehydrogenase activity|NAD-linked isocitrate dehydrogenase activity|NAD-specific isocitrate dehydrogenase activity|isocitrate dehydrogenase (NAD) activity|isocitrate:NAD+ oxidoreductase (decarboxylating)|nicotinamide adenine dinucleotide isocitrate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004449 GO:0004444 biolink:MolecularActivity obsolete inositol-1,4,5-trisphosphate 1-phosphatase OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate. go.json inositol-1,4,5-trisphosphate 1-phosphatase True http://purl.obolibrary.org/obo/GO_0004444 GO:0004443 biolink:MolecularActivity obsolete inositol-1,4,-bisphosphate 4-phosphatase OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate. go.json inositol-1,4,-bisphosphate 4-phosphatase True http://purl.obolibrary.org/obo/GO_0004443 GO:0004446 biolink:MolecularActivity inositol-hexakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. EC:3.1.3.62|MetaCyc:RXN-7920 go.json 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity|MIPP activity|inositol tetrakisphosphate phosphomonoesterase activity|multiple inositol-polyphosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0004446 GO:0004445 biolink:MolecularActivity inositol-polyphosphate 5-phosphatase activity Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. EC:3.1.3.56 go.json 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity|5PTase activity|D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity|D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity|D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity|Ins(1,4,5)P(3) 5-phosphatase activity|Ins(1,4,5)P3 5-phosphatase activity|Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity|InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity|InsP3/Ins(1,3,4,5)P4 5-phosphatase activity|L-myo-inositol 1,4,5-trisphosphate-monoesterase activity|inosine triphosphatase activity|inositol 1,4,5-trisphosphate phosphatase activity|inositol phosphate 5-phosphomonoesterase activity|inositol polyphosphate-5-phosphatase activity|inositol triphosphate 5-phosphomonoesterase activity|inositol trisphosphate phosphomonoesterase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity|myo-inositol-1,4,5-trisphosphate 5-phosphatase activity|type I inositol-polyphosphate phosphatase activity|type II inositol polyphosphate 5-phosphatase activity|type II inositol-1,4,5-trisphosphate 5-phosphatase activity http://purl.obolibrary.org/obo/GO_0004445 GO:0004440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004440 GO:0004442 biolink:MolecularActivity obsolete inositol-1,4,-bisphosphate 3-phosphatase OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate. go.json inositol-1,4,-bisphosphate 3-phosphatase True http://purl.obolibrary.org/obo/GO_0004442 GO:0004441 biolink:MolecularActivity inositol-1,4-bisphosphate 1-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. EC:3.1.3.57|MetaCyc:3.1.3.57-RXN|RHEA:15553|Reactome:R-HSA-1855208 go.json 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity|inositol polyphosphate 1-phosphatase activity|inositol-polyphosphate 1-phosphatase activity http://purl.obolibrary.org/obo/GO_0004441 GO:0004459 biolink:MolecularActivity L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. EC:1.1.1.27|MetaCyc:L-LACTATE-DEHYDROGENASE-RXN|RHEA:23444|Reactome:R-HSA-6807826|Reactome:R-HSA-70510|Reactome:R-HSA-71849 go.json L-lactic acid dehydrogenase activity|L-lactic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004459 GO:0004458 biolink:MolecularActivity D-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. EC:1.1.2.4|MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:13521 go.json (R)-lactate:ferricytochrome-c 2-oxidoreductase activity|D-(-)-lactic cytochrome c reductase activity|D-lactate (cytochrome) dehydrogenase activity|D-lactate ferricytochrome c oxidoreductase activity|D-lactate-cytochrome c reductase activity|cytochrome-dependent D-(-)-lactate dehydrogenase activity|lactic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004458 GO:0004455 biolink:MolecularActivity ketol-acid reductoisomerase activity Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. EC:1.1.1.86|MetaCyc:ACETOLACTREDUCTOISOM-RXN|RHEA:22068 go.json (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)|2-hydroxy-3-keto acid reductoisomerase activity|acetohydroxy acid isomeroreductase activity|acetohydroxy acid reductoisomerase activity|acetolactate reductoisomerase activity|alpha-keto-beta-hydroxylacyl reductoisomerase activity|dihydroxyisovalerate (isomerizing) dehydrogenase activity|dihydroxyisovalerate dehydrogenase (isomerizing) activity|isomeroreductase activity|ketol acid reductoisomerase activity|reductoisomerase activity http://purl.obolibrary.org/obo/GO_0004455 GO:0004454 biolink:MolecularActivity ketohexokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. EC:2.7.1.3|MetaCyc:KETOHEXOKINASE-RXN|RHEA:18145|Reactome:R-HSA-5656459|Reactome:R-HSA-70333 go.json ATP:D-fructose 1-phosphotransferase activity|hepatic fructokinase activity|ketohexokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004454 GO:0004457 biolink:MolecularActivity lactate dehydrogenase activity Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. go.json http://purl.obolibrary.org/obo/GO_0004457 GO:0004456 biolink:MolecularActivity phosphogluconate dehydratase activity Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O. EC:4.2.1.12|KEGG_REACTION:R02036|MetaCyc:PGLUCONDEHYDRAT-RXN|RHEA:17277 go.json 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)|6-phospho-D-gluconate hydro-lyase activity|6-phosphogluconate dehydrase activity|6-phosphogluconate dehydratase activity|6-phosphogluconic dehydrase activity|gluconate 6-phosphate dehydratase activity|gluconate-6-phosphate dehydratase activity http://purl.obolibrary.org/obo/GO_0004456 GO:0004451 biolink:MolecularActivity isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate. EC:4.1.3.1|KEGG_REACTION:R00479|MetaCyc:ISOCIT-CLEAV-RXN|RHEA:13245 go.json ICL activity|isocitrase activity|isocitratase activity|isocitrate glyoxylate-lyase (succinate-forming)|isocitrate glyoxylate-lyase activity|isocitritase activity|threo-DS-isocitrate glyoxylate-lyase activity http://purl.obolibrary.org/obo/GO_0004451 GO:0004450 biolink:MolecularActivity isocitrate dehydrogenase (NADP+) activity Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. EC:1.1.1.42|MetaCyc:ISOCITDEH-RXN|RHEA:19629|Reactome:R-HSA-389540|Reactome:R-HSA-389550|Reactome:R-HSA-450984 go.json NADP isocitric dehydrogenase activity|NADP(+)-ICDH activity|NADP(+)-IDH activity|NADP(+)-linked isocitrate dehydrogenase activity|NADP-dependent isocitrate dehydrogenase activity|NADP-dependent isocitric dehydrogenase activity|NADP-linked isocitrate dehydrogenase activity|NADP-specific isocitrate dehydrogenase activity|dual-cofactor-specific isocitrate dehydrogenase activity|isocitrate (NADP) dehydrogenase activity|isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|isocitrate dehydrogenase (NADP) activity|isocitrate dehydrogenase (NADP-dependent) activity|isocitrate:NADP+ oxidoreductase (decarboxylating)|triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004450 GO:0004453 biolink:MolecularActivity juvenile-hormone esterase activity Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone. EC:3.1.1.59|MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN|RHEA:16393 go.json JH esterase activity|JH-esterase activity|juvenile hormone analog esterase activity|juvenile hormone carboxyesterase activity|methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity http://purl.obolibrary.org/obo/GO_0004453 goslim_chembl GO:0004452 biolink:MolecularActivity isopentenyl-diphosphate delta-isomerase activity Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. EC:5.3.3.2|KEGG_REACTION:R01123|MetaCyc:IPPISOM-RXN|RHEA:23284|Reactome:R-HSA-191382 go.json IPP isomerase activity|isopentenyl-diphosphate D-isomerase activity|isopentenyl-diphosphate delta3-delta2-isomerase activity|isopentenylpyrophosphate delta-isomerase activity|isopentenylpyrophosphate isomerase activity|methylbutenylpyrophosphate isomerase activity http://purl.obolibrary.org/obo/GO_0004452 GO:0004426 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004426 GO:0004425 biolink:MolecularActivity indole-3-glycerol-phosphate synthase activity Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. EC:4.1.1.48|MetaCyc:IGPSYN-RXN|RHEA:23476 go.json 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)|1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]|indole-3-glycerophosphate synthase activity|indoleglycerol phosphate synthase activity|indoleglycerol phosphate synthetase activity http://purl.obolibrary.org/obo/GO_0004425 GO:0004428 biolink:MolecularActivity obsolete inositol or phosphatidylinositol kinase activity OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. go.json inositol or phosphatidylinositol kinase activity|inositol/phosphatidylinositol kinase activity True http://purl.obolibrary.org/obo/GO_0004428 GO:0004427 biolink:MolecularActivity inorganic diphosphate phosphatase activity Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. EC:3.6.1.1|KEGG_REACTION:R00004|MetaCyc:INORGPYROPHOSPHAT-RXN|RHEA:24576|Reactome:R-HSA-449937|Reactome:R-HSA-6788912|Reactome:R-HSA-71732 go.json diphosphate phosphohydrolase activity|inorganic diphosphatase activity|inorganic pyrophosphatase activity|pyrophosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0004427 GO:0004422 biolink:MolecularActivity hypoxanthine phosphoribosyltransferase activity Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. EC:2.4.2.8|KEGG_REACTION:R01132|MetaCyc:HYPOXANPRIBOSYLTRAN-RXN|RHEA:17973 go.json 6-hydroxypurine phosphoribosyltransferase activity|6-mercaptopurine phosphoribosyltransferase activity|HGPRTase activity|HPRT|IMP diphosphorylase activity|IMP pyrophosphorylase activity|IMP-GMP pyrophosphorylase activity|IMP:diphosphate phospho-D-ribosyltransferase activity|Transphosphoribosidase activity|guanine-hypoxanthine phosphoribosyltransferase activity|hypoxanthine-guanine phosphoribosyltransferase activity|inosinate pyrophosphorylase activity|inosine 5'-phosphate pyrophosphorylase activity|inosinic acid pyrophosphorylase activity|inosinic pyrophosphorylase activity|purine-6-thiol phosphoribosyltransferase activity http://purl.obolibrary.org/obo/GO_0004422 GO:0004421 biolink:MolecularActivity hydroxymethylglutaryl-CoA synthase activity Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+. EC:2.3.3.10|KEGG_REACTION:R01978|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN|RHEA:10188|Reactome:R-HSA-191323|Reactome:R-HSA-73918 go.json (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)|(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity|3-hydroxy-3-methylglutaryl CoA synthetase activity|3-hydroxy-3-methylglutaryl coenzyme A synthase activity|3-hydroxy-3-methylglutaryl coenzyme A synthetase activity|3-hydroxy-3-methylglutaryl-CoA synthase activity|3-hydroxy-3-methylglutaryl-coenzyme A synthase activity|HMG-CoA synthase activity|acetoacetyl coenzyme A transacetase activity|acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|beta-hydroxy-beta-methylglutaryl-CoA synthase activity|hydroxymethylglutaryl coenzyme A synthase activity|hydroxymethylglutaryl coenzyme A-condensing enzyme|hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity http://purl.obolibrary.org/obo/GO_0004421 GO:0004424 biolink:MolecularActivity imidazoleglycerol-phosphate dehydratase activity Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. EC:4.2.1.19|KEGG_REACTION:R03457|MetaCyc:IMIDPHOSDEHYD-RXN|RHEA:11040 go.json D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]|D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity|IGP dehydratase activity|imidazoleglycerol phosphate dehydratase activity http://purl.obolibrary.org/obo/GO_0004424 GO:0004423 biolink:MolecularActivity iduronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. EC:3.1.6.13|MetaCyc:3.1.6.13-RXN|Reactome:R-HSA-1678650|Reactome:R-HSA-1793182|Reactome:R-HSA-2262743|Reactome:R-HSA-9036046 go.json 2-sulfo-L-iduronate 2-sulfatase activity|L-iduronate 2-sulfate sulfatase activity|L-iduronate-2-sulfate 2-sulfohydrolase activity|L-idurono sulfate sulfatase activity|L-iduronosulfatase activity|chondroitinsulfatase|iduronate sulfatase activity|iduronate sulfate sulfatase activity|iduronate-2-sulfate sulfatase activity|iduronate-2-sulphatase activity|iduronide-2-sulfate sulfatase activity|idurono-2-sulfatase activity|sulfo-L-iduronate sulfatase activity|sulfoiduronate sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0004423 GO:0004420 biolink:MolecularActivity hydroxymethylglutaryl-CoA reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH. EC:1.1.1.34|KEGG_REACTION:R02082|MetaCyc:1.1.1.34-RXN|RHEA:15989|Reactome:R-HSA-191352 go.json 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|HMG-CoA reductase activity|hydroxymethylglutaryl-CoA reductase activity http://purl.obolibrary.org/obo/GO_0004420 GO:0004429 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004429 GO:0004437 biolink:MolecularActivity obsolete inositol or phosphatidylinositol phosphatase activity OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. go.json inositol or phosphatidylinositol phosphatase activity|inositol/phosphatidylinositol phosphatase activity True http://purl.obolibrary.org/obo/GO_0004437 GO:0004436 biolink:MolecularActivity phosphatidylinositol diacylglycerol-lyase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. EC:4.6.1.13|MetaCyc:3.1.4.10-RXN|RHEA:17093 go.json 1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)|1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)|1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)|1-phosphatidylinositol phosphodiesterase activity|monophosphatidylinositol phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004436 GO:0004439 biolink:MolecularActivity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. EC:3.1.3.36|KEGG_REACTION:R04404|MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN|RHEA:22764|Reactome:R-HSA-1675824|Reactome:R-HSA-1676177|Reactome:R-HSA-8868648 go.json PI(4,5)P2 5-phosphatase activity|PtdIns(4,5)P(2) 5-phosphatase activity|PtdIns(4,5)P2 5-phosphatase activity|phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity|phosphatidylinositol 4,5-bisphosphate phosphatase activity|phosphatidylinositol-bisphosphatase activity|triphosphoinositide phosphatase activity|triphosphoinositide phosphomonoesterase activity http://purl.obolibrary.org/obo/GO_0004439 GO:0004438 biolink:MolecularActivity phosphatidylinositol-3-phosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. EC:3.1.3.64|MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN|RHEA:12316|Reactome:R-HSA-1675795|Reactome:R-HSA-1675994|Reactome:R-HSA-1676114|Reactome:R-HSA-1676141|Reactome:R-HSA-6809325|Reactome:R-HSA-6809720|Reactome:R-HSA-6809777|Reactome:R-HSA-6809975 go.json 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity|D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity|inositol 1,3-bisphosphate phosphatase activity|inositol-1,3-bisphosphate 3-phosphatase activity|inositol-polyphosphate 3-phosphatase activity|phosphatidyl-3-phosphate 3-phosphohydrolase activity|phosphatidylinositol-3-phosphatase activity http://purl.obolibrary.org/obo/GO_0004438 GO:0004433 biolink:MolecularActivity obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins. go.json 1-phosphatidylinositol-4-phosphate kinase, class IB True http://purl.obolibrary.org/obo/GO_0004433 GO:0004432 biolink:MolecularActivity obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events. go.json 1-phosphatidylinositol-4-phosphate kinase, class IA True http://purl.obolibrary.org/obo/GO_0004432 GO:0004435 biolink:MolecularActivity phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+. EC:3.1.4.11|KEGG_REACTION:R03435|MetaCyc:3.1.4.11-RXN|RHEA:33179|Reactome:R-HSA-111879|Reactome:R-HSA-167686|Reactome:R-HSA-1855177|Reactome:R-HSA-1855214|Reactome:R-HSA-1855221|Reactome:R-HSA-202407|Reactome:R-HSA-2730847|Reactome:R-HSA-5607735|Reactome:R-HSA-622382|Reactome:R-HSA-9032478|Reactome:R-HSA-9717205 go.json 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity|1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity|PI-PLC activity|monophosphatidylinositol phosphodiesterase activity|phosphatidylinositol-4,5-bisphosphate hydrolysis|phosphoinositidase C activity|phosphoinositide phospholipase C activity|triphosphoinositide phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004435 GO:0004434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004434 GO:0004431 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004431 GO:0004430 biolink:MolecularActivity 1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+. EC:2.7.1.67|KEGG_REACTION:R03361|MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN|RHEA:19877|Reactome:R-HSA-1675780|Reactome:R-HSA-1675813|Reactome:R-HSA-1675883|Reactome:R-HSA-1675974|Reactome:R-HSA-1676185 go.json PI 4-kinase activity|PI kinase activity|PI4-kinase activity|PI4K|PI4K-alpha activity|PtdIns-4-kinase activity|phosphatidylinositol 4-kinase activity|phosphatidylinositol kinase (phosphorylating) activity|phosphatidylinositol kinase activity|type II phosphatidylinositol kinase activity http://purl.obolibrary.org/obo/GO_0004430 GO:0004525 biolink:MolecularActivity ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. EC:3.1.26.3|MetaCyc:3.1.26.3-RXN|Reactome:R-HSA-203862|Reactome:R-HSA-203893|Reactome:R-HSA-426464|Reactome:R-HSA-9708292|Reactome:R-HSA-9708408|Reactome:R-HSA-9820840 go.json RNase III activity|pre-mRNA 3'-end processing endonuclease|ribonuclease 3 activity http://purl.obolibrary.org/obo/GO_0004525 GO:0004524 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004524 GO:0004527 biolink:MolecularActivity exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. go.json exonuclease IX activity http://purl.obolibrary.org/obo/GO_0004527 GO:0004526 biolink:MolecularActivity ribonuclease P activity Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. EC:3.1.26.5|MetaCyc:3.1.26.5-RXN|Reactome:R-HSA-5696810|Wikipedia:RNase_P go.json RNase P|tRNA 5' leader endonuclease activity http://purl.obolibrary.org/obo/GO_0004526 GO:0004521 biolink:MolecularActivity RNA endonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. Reactome:R-HSA-425923|Reactome:R-HSA-426520|Reactome:R-HSA-5601887|Reactome:R-HSA-5601910|Reactome:R-HSA-6791223|Reactome:R-HSA-6814555|Reactome:R-HSA-9009936|Reactome:R-HSA-9009941|Reactome:R-HSA-9023909|Reactome:R-HSA-9023912|Reactome:R-HSA-927836|Reactome:R-HSA-9708327|Reactome:R-HSA-9708812 go.json endonuclease G activity|endoribonuclease activity http://purl.obolibrary.org/obo/GO_0004521 GO:0004520 biolink:MolecularActivity DNA endonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. Reactome:R-HSA-110359|Reactome:R-HSA-5686440|Reactome:R-HSA-5686657|Reactome:R-HSA-5687464|Reactome:R-HSA-5690988|Reactome:R-HSA-5693584|Reactome:R-HSA-5693608|Reactome:R-HSA-6782204|Reactome:R-HSA-6782224|Reactome:R-HSA-9023941 go.json DNA nicking activity|endodeoxyribonuclease activity|endonuclease G activity http://purl.obolibrary.org/obo/GO_0004520 GO:0004523 biolink:MolecularActivity RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. EC:3.1.26.4|MetaCyc:3.1.26.4-RXN|Reactome:R-HSA-164519|Reactome:R-HSA-164528|Reactome:R-HSA-173769|Reactome:R-HSA-182795|Reactome:R-HSA-182859 go.json RNA*DNA hybrid ribonucleotidohydrolase activity|RNase H activity|RNase H1 activity|RNase H2 activity|RNase H3 activity|calf thymus ribonuclease H activity|endoribonuclease H|endoribonuclease H (calf thymus)|endoribonuclease0 H activity|hybrid nuclease activity|hybrid ribonuclease activity|hybridase (ribonuclease H)|hybridase activity|ribonuclease H activity|ribonuclease H1 activity|ribonuclease H2 activity|ribonuclease H3 activity http://purl.obolibrary.org/obo/GO_0004523 GO:0004522 biolink:MolecularActivity ribonuclease A activity Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. EC:4.6.1.18|MetaCyc:3.1.27.5-RXN|Wikipedia:Ribonuclease_A go.json RNase A activity|RNase I activity|RNase activity|S-genotype-assocd. glycoproteins|SLSG glycoproteins|alkaline ribonuclease activity|ceratitis capitata alkaline ribonuclease activity|endoribonuclease I|gene S glycoproteins|gene S locus-specific glycoproteins|pancreatic RNase activity|pancreatic ribonuclease activity|ribonuclease I activity|ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity|ribonucleic phosphatase activity http://purl.obolibrary.org/obo/GO_0004522 GO:0004529 biolink:MolecularActivity DNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. go.json http://purl.obolibrary.org/obo/GO_0004529 GO:0004528 biolink:MolecularActivity phosphodiesterase I activity Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. EC:3.1.4.1|MetaCyc:3.1.4.1-RXN go.json 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|5'-NPDase activity|5'-PDE activity|5'-PDase activity|5'-exonuclease activity|5'-nucleotide phosphodiesterase activity|5'-phosphodiesterase activity|5'NPDE activity|PDE I activity|alkaline phosphodiesterase activity|exonuclease I activity|nucleotide pyrophosphatase/phosphodiesterase I activity|oligonucleate 5'-nucleotidohydrolase activity|orthophosphoric diester phosphohydrolase activity|phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004528 GO:0004536 biolink:MolecularActivity DNA nuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. Reactome:R-HSA-211247|Reactome:R-HSA-5685994|Reactome:R-HSA-6785986 go.json caspase-activated deoxyribonuclease activity|deoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0004536 GO:0004535 biolink:MolecularActivity poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. EC:3.1.13.4|MetaCyc:3.1.13.4-RXN|Reactome:R-HSA-429955|Reactome:R-HSA-429992|Reactome:R-HSA-430021|Reactome:R-HSA-9822311|Reactome:R-HSA-9822335 go.json 2',3'-exoribonuclease activity|3'-exoribonuclease activity|poly(A)-specific RNase activity http://purl.obolibrary.org/obo/GO_0004535 GO:0004537 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004537 GO:0004532 biolink:MolecularActivity RNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. Reactome:R-HSA-429961 go.json exoribonuclease activity http://purl.obolibrary.org/obo/GO_0004532 GO:0004531 biolink:MolecularActivity deoxyribonuclease II activity Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. EC:3.1.22.1|MetaCyc:3.1.22.1-RXN go.json DNase II activity|acid DNase activity|acid deoxyribonuclease activity|deoxyribonucleate 3'-nucleotidohydrolase activity|lysosomal DNase II activity|pancreatic DNase II http://purl.obolibrary.org/obo/GO_0004531 GO:0004534 biolink:MolecularActivity 5'-3' RNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. EC:3.1.13.-|Reactome:R-HSA-429845 go.json 5'-3' exoribonuclease activity http://purl.obolibrary.org/obo/GO_0004534 GO:0004533 biolink:MolecularActivity exoribonuclease H activity Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions. EC:3.1.13.2|MetaCyc:3.1.13.2-RXN go.json retroviral reverse transcriptase RNaseH http://purl.obolibrary.org/obo/GO_0004533 GO:0004530 biolink:MolecularActivity deoxyribonuclease I activity Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. EC:3.1.21.1|MetaCyc:3.1.21.1-RXN go.json DNA depolymerase activity|DNA endonuclease activity|DNA nuclease activity|DNAase activity|DNase I|DNase activity|Escherichia coli endonuclease I|alkaline DNase activity|alkaline deoxyribonuclease activity|deoxyribonuclease (pancreatic)|deoxyribonuclease A|deoxyribonucleic phosphatase activity|dornava|dornavac|endodeoxyribonuclease I|pancreatic DNase activity|pancreatic deoxyribonuclease|pancreatic dornase|thymonuclease activity|thymonuclease, dornase activity http://purl.obolibrary.org/obo/GO_0004530 GO:0004503 biolink:MolecularActivity tyrosinase activity Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. EC:1.14.18.1|MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN go.json L-tyrosine monooxygenase activity|N-acetyl-6-hydroxytryptophan oxidase activity|catecholase|chlorogenic acid oxidase activity|chlorogenic oxidase activity|cresolase activity|dopa oxidase|monophenol monooxidase activity|monophenol monooxygenase activity|monophenol oxidase activity|monophenol oxygenase|monophenolase activity|o-diphenol oxidase activity|o-diphenol oxidoreductase|o-diphenol:O2 oxidoreductase activity|phenol oxidase activity|phenolase activity|prophenol oxidase activity|prophenoloxidase activity|pyrocatechol oxidase|tyrosine-dopa oxidase activity http://purl.obolibrary.org/obo/GO_0004503 GO:0004502 biolink:MolecularActivity kynurenine 3-monooxygenase activity Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+. EC:1.14.13.9|KEGG_REACTION:R01960|MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN|RHEA:20545|Reactome:R-HSA-71200 go.json L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)|L-kynurenine-3-hydroxylase activity|kynurenine 3-hydroxylase activity|kynurenine hydroxylase activity http://purl.obolibrary.org/obo/GO_0004502 GO:0004505 biolink:MolecularActivity phenylalanine 4-monooxygenase activity Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. EC:1.14.16.1|MetaCyc:RXN66-569|RHEA:20273|Reactome:R-HSA-5649483|Reactome:R-HSA-71118 go.json L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)|PAH activity|phenylalaninase activity|phenylalanine 4-hydroxylase activity|phenylalanine hydroxylase activity http://purl.obolibrary.org/obo/GO_0004505 GO:0004504 biolink:MolecularActivity peptidylglycine monooxygenase activity Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. EC:1.14.17.3|MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN|RHEA:21452 go.json PAM activity|PAM-A|PAM-B|peptide alpha-amidating enzyme|peptide alpha-amide synthase activity|peptide-alpha-amide synthetase activity|peptidyl alpha-amidating enzyme activity|peptidylglycine 2-hydroxylase activity|peptidylglycine alpha-amidating monooxygenase activity|peptidylglycine alpha-hydroxylase activity|peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)|synthase, peptide alpha-amide http://purl.obolibrary.org/obo/GO_0004504 GO:0004501 biolink:MolecularActivity ecdysone 20-monooxygenase activity Catalysis of the reaction: AH(2) + Ecdysone + O2 = 20-hydroxyecdysone + A + H2O. EC:1.14.99.22|KEGG_REACTION:R02374|MetaCyc:RXN-18799|RHEA:14021 go.json alpha-ecdysone C-20 hydroxylase activity|ecdysone 20-hydroxylase activity|ecdysone modification|ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating) http://purl.obolibrary.org/obo/GO_0004501 GO:0004500 biolink:MolecularActivity dopamine beta-monooxygenase activity Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O. EC:1.14.17.1|KEGG_REACTION:R02535|MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN|RHEA:19117|Reactome:R-HSA-209891 go.json (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity|3,4-dihydroxyphenethylamine beta-oxidase activity|3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)|4-(2-aminoethyl)pyrocatechol beta-oxidase activity|MDBH (membrane-associated dopamine beta-monooxygenase)|SDBH (soluble dopamine beta-monooxygenase)|dopa beta-hydroxylase activity|dopamine b-hydroxylase activity|dopamine beta-hydroxylase activity|dopamine beta-oxidase activity|dopamine hydroxylase activity|dopamine-B-hydroxylase activity|oxygenase, dopamine beta-mono-|phenylamine beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0004500 GO:0004507 biolink:MolecularActivity steroid 11-beta-monooxygenase activity Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. EC:1.14.15.4|MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN|RHEA:15629|Reactome:R-HSA-193997|Reactome:R-HSA-194017|Reactome:R-HSA-5580292|Reactome:R-HSA-5600598 go.json cytochrome P450 CYP11B1|cytochrome P450 CYP11B2|cytochrome p450 XIB1 activity|oxygenase, steroid 11beta -mono-|steroid 11-beta-hydroxylase activity|steroid 11-beta/18-hydroxylase activity|steroid 11beta-hydroxylase activity|steroid 11beta-monooxygenase activity|steroid 11beta/18-hydroxylase activity|steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) http://purl.obolibrary.org/obo/GO_0004507 GO:0004506 biolink:MolecularActivity squalene monooxygenase activity Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+. EC:1.14.14.17|KEGG_REACTION:R02874|MetaCyc:SQUALENE-MONOOXYGENASE-RXN|RHEA:25282|Reactome:R-HSA-191299 go.json squalene 2,3-oxidocyclase activity|squalene epoxidase activity|squalene hydroxylase activity|squalene oxydocyclase activity|squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity|squalene-2,3-epoxidase activity|squalene-2,3-epoxide cyclase activity http://purl.obolibrary.org/obo/GO_0004506 GO:0004509 biolink:MolecularActivity steroid 21-monooxygenase activity Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O. EC:1.14.14.16|MetaCyc:STEROID-21-MONOOXYGENASE-RXN|RHEA:65612|Reactome:R-HSA-193964|Reactome:R-HSA-193981|Reactome:R-HSA-5601976 go.json 21-hydroxylase activity|cytochrome P450 CYP21A1|cytochrome p450 XXIA1 activity|steroid 21-hydroxylase activity|steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating) http://purl.obolibrary.org/obo/GO_0004509 GO:0004508 biolink:MolecularActivity steroid 17-alpha-monooxygenase activity Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. EC:1.14.14.19|MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN|Reactome:R-HSA-193068|Reactome:R-HSA-193070|Reactome:R-HSA-193072|Reactome:R-HSA-193099|Reactome:R-HSA-5601843|Reactome:R-HSA-9035954|Reactome:R-HSA-9035956 go.json 17alpha-hydroxylase-C17,20 lyase activity|cytochrome P-450 (P-45017alpha,lyase)|cytochrome P450 CYP17|cytochrome P45017alpha|cytochrome p450 XVIIA1 activity|steroid 17-alpha-hydroxylase activity|steroid 17-alpha-hydroxylase-C17-20 lyase activity|steroid 17-alpha-hydroxylase/17,20 lyase activity|steroid 17alpha-hydroxylase activity|steroid 17alpha-monooxygenase activity|steroid 17alphahydroxylase/17,20 lyase activity|steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) http://purl.obolibrary.org/obo/GO_0004508 GO:0004514 biolink:MolecularActivity nicotinate-nucleotide diphosphorylase (carboxylating) activity Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate. EC:2.4.2.19|KEGG_REACTION:R03348|MetaCyc:QUINOPRIBOTRANS-RXN|RHEA:12733|Reactome:R-HSA-197268 go.json NAD pyrophosphorylase activity|QAPRTase activity|nicotinate mononucleotide pyrophosphorylase (carboxylating)|nicotinate-nucleotide pyrophosphorylase (carboxylating) activity|nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)|quinolinate phosphoribosyltransferase (decarboxylating) activity|quinolinic acid phosphoribosyltransferase activity|quinolinic phosphoribosyltransferase activity http://purl.obolibrary.org/obo/GO_0004514 GO:0004513 biolink:MolecularActivity obsolete neolactotetraosylceramide alpha-2,3-sialyltransferase activity OBSOLETE. Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide. go.json N-acetyllactosaminide alpha-2,3-sialyltransferase|alpha2->3 sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase True http://purl.obolibrary.org/obo/GO_0004513 GO:0004516 biolink:MolecularActivity nicotinate phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. EC:6.3.4.21|KEGG_REACTION:R01724|MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN|RHEA:36163|Reactome:R-HSA-197186 go.json niacin ribonucleotidase activity|nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity|nicotinic acid mononucleotide glycohydrolase activity|nicotinic acid mononucleotide pyrophosphorylase activity|nicotinic acid phosphoribosyltransferase activity http://purl.obolibrary.org/obo/GO_0004516 GO:0004515 biolink:MolecularActivity nicotinate-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. EC:2.7.7.18|MetaCyc:NICONUCADENYLYLTRAN-RXN|RHEA:22860|Reactome:R-HSA-197235|Reactome:R-HSA-200474|Reactome:R-HSA-200512 go.json ATP:nicotinate-nucleotide adenylyltransferase activity|ATP:nicotinate-ribonucleotide adenylyltransferase activity|NaMN-ATase activity|deamido-NAD(+) diphosphorylase activity|deamido-NAD(+) pyrophosphorylase activity|deamido-NAD+ pyrophosphorylase activity|deamidonicotinamide adenine dinucleotide pyrophosphorylase activity|nicotinate mononucleotide adenylyltransferase activity|nicotinic acid mononucleotide adenylyltransferase http://purl.obolibrary.org/obo/GO_0004515 GO:0004510 biolink:MolecularActivity tryptophan 5-monooxygenase activity Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. EC:1.14.16.4|MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN|RHEA:16709|Reactome:R-HSA-209828 go.json L-tryptophan hydroxylase activity|L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)|indoleacetic acid-5-hydroxylase activity|tryptophan 5-hydroxylase activity|tryptophan hydroxylase activity http://purl.obolibrary.org/obo/GO_0004510 GO:0004512 biolink:MolecularActivity inositol-3-phosphate synthase activity Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. EC:5.5.1.4|KEGG_REACTION:R07324|MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN|RHEA:10716|Reactome:R-HSA-1855178 go.json 1L-myo-inositol-1-phosphate lyase (isomerizing)|D-glucose 6-phosphate cycloaldolase activity|glucocycloaldolase activity|glucose 6-phosphate cyclase activity|glucose-6-phosphate inositol monophosphate cycloaldolase activity|inositol 1-phosphate synthatase activity|inositol 1-phosphate synthetase activity http://purl.obolibrary.org/obo/GO_0004512 GO:0004511 biolink:MolecularActivity tyrosine 3-monooxygenase activity Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. EC:1.14.16.2|MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN|RHEA:18201|Reactome:R-HSA-209823 go.json L-tyrosine hydroxylase activity|L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|tyrosine 3-hydroxylase activity|tyrosine hydroxylase activity http://purl.obolibrary.org/obo/GO_0004511 GO:0004518 biolink:MolecularActivity nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids. go.json http://purl.obolibrary.org/obo/GO_0004518 goslim_chembl|goslim_drosophila|goslim_plant|goslim_yeast GO:0004517 biolink:MolecularActivity nitric-oxide synthase activity Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. EC:1.14.13.39|MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN|RHEA:19897|Reactome:R-HSA-202127|Reactome:R-HSA-418436 go.json L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity|NADPH-diaphorase activity|NO synthase activity|endothelium-derived relaxation factor-forming enzyme activity|endothelium-derived relaxing factor synthase activity|nitric oxide synthase activity|nitric oxide synthetase activity|nitric-oxide synthetase activity http://purl.obolibrary.org/obo/GO_0004517 GO:0004519 biolink:MolecularActivity endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. Reactome:R-HSA-5358512|Reactome:R-HSA-5358518|Reactome:R-HSA-5690990|Reactome:R-HSA-5693533|Reactome:R-HSA-72180 go.json http://purl.obolibrary.org/obo/GO_0004519 GO:0004587 biolink:MolecularActivity ornithine aminotransferase activity Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde. EC:2.6.1.13|MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN|MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN|RHEA:13877|Reactome:R-HSA-70654|Reactome:R-HSA-70666 go.json GabT|L-ornithine 5-aminotransferase activity|L-ornithine aminotransferase activity|L-ornithine:2-oxo-acid aminotransferase activity|L-ornithine:alpha-ketoglutarate delta-aminotransferase activity|OAT|ornithine 5-aminotransferase activity|ornithine delta-transaminase activity|ornithine ketoacid aminotransferase activity|ornithine transaminase activity|ornithine(lysine) transaminase activity|ornithine--2-oxoacid aminotransferase activity|ornithine--alpha-ketoglutarate aminotransferase activity|ornithine--keto acid aminotransferase activity|ornithine--keto acid transaminase activity|ornithine--ketoglutarate aminotransferase activity|ornithine--oxo acid aminotransferase activity|ornithine--oxo-acid transaminase activity|ornithine-oxo-acid aminotransferase activity|ornithine-oxo-acid transaminase activity|ornithine:alpha-oxoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0004587 GO:0004586 biolink:MolecularActivity ornithine decarboxylase activity Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine. EC:4.1.1.17|KEGG_REACTION:R00670|MetaCyc:ORNDECARBOX-RXN|RHEA:22964|Reactome:R-HSA-70692 go.json L-ornithine carboxy-lyase (putrescine-forming)|L-ornithine carboxy-lyase activity|SpeC http://purl.obolibrary.org/obo/GO_0004586 GO:0004589 biolink:MolecularActivity dihydroorotate dehydrogenase (NADH) activity Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate. EC:1.3.1.14|KEGG_REACTION:R01869|MetaCyc:OROTATE-REDUCTASE-NADH-RXN|RHEA:13513 go.json (S)-dihydroorotate:NAD+ oxidoreductase activity|orotate reductase (NADH) activity http://purl.obolibrary.org/obo/GO_0004589 GO:0004588 biolink:MolecularActivity orotate phosphoribosyltransferase activity Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. EC:2.4.2.10|MetaCyc:OROPRIBTRANS-RXN|RHEA:10380|Reactome:R-HSA-73567 go.json OPRT activity|OPRTase activity|orotate phosphoribosyl pyrophosphate transferase activity|orotic acid phosphoribosyltransferase activity|orotidine 5'-monophosphate pyrophosphorylase activity|orotidine monophosphate pyrophosphorylase activity|orotidine phosphoribosyltransferase activity|orotidine-5'-phosphate diphosphorylase activity|orotidine-5'-phosphate pyrophosphorylase activity|orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity|orotidylate phosphoribosyltransferase activity|orotidylate pyrophosphorylase activity|orotidylic acid phosphorylase activity|orotidylic acid pyrophosphorylase activity|orotidylic phosphorylase activity|orotidylic pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0004588 GO:0004583 biolink:MolecularActivity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide. MetaCyc:RXN-5472|Reactome:R-HSA-446189|Reactome:R-HSA-446194|Reactome:R-HSA-446202|Reactome:R-HSA-4724291|Reactome:R-HSA-4724330 go.json http://purl.obolibrary.org/obo/GO_0004583 GO:0004582 biolink:MolecularActivity dolichyl-phosphate beta-D-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. EC:2.4.1.83|MetaCyc:2.4.1.83-RXN|RHEA:21184|Reactome:R-HSA-162721|Reactome:R-HSA-4717406|Reactome:R-HSA-4719354|Reactome:R-HSA-4719375 go.json DPM synthase activity|GDP-mannose-dolichol phosphate mannosyltransferase activity|GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity|GDPMan:DolP mannosyltransferase activity|GDPmannose-dolichylmonophosphate mannosyltransferase activity|GDPmannose:dolichyl-phosphate mannosyltransferase activity|dolichol phosphate mannose synthase activity|dolichol-phosphate mannose synthase activity|dolichol-phosphate mannosyltransferase activity|dolichol-phosphate-mannose synthase activity|dolichyl mannosyl phosphate synthase activity|dolichyl phosphate mannosyltransferase activity|dolichyl-phosphate mannose synthase activity|dolichyl-phospho-mannose synthase activity|guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity|mannosylphosphodolichol synthase activity|mannosylphosphoryldolichol synthase activity http://purl.obolibrary.org/obo/GO_0004582 GO:0004585 biolink:MolecularActivity ornithine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. EC:2.1.3.3|MetaCyc:ORNCARBAMTRANSFER-RXN|RHEA:19513|Reactome:R-HSA-70560 go.json L-ornithine carbamoyltransferase activity|L-ornithine carbamyltransferase activity|L-ornithine transcarbamylase activity|OTC activity|OTCase activity|carbamoyl-phosphate:L-ornithine carbamoyltransferase activity|carbamylphosphate-ornithine transcarbamylase activity|citrulline phosphorylase activity|ornithine carbamyltransferase activity|ornithine transcarbamylase activity http://purl.obolibrary.org/obo/GO_0004585 GO:0004584 biolink:MolecularActivity obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity OBSOLETE. Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide. EC:2.4.1.130|MetaCyc:2.4.1.130-RXN go.json dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity|dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity|oligomannosylsynthase activity True http://purl.obolibrary.org/obo/GO_0004584 GO:0004581 biolink:MolecularActivity dolichyl-phosphate beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. EC:2.4.1.117|MetaCyc:2.4.1.117-RXN|RHEA:15401|Reactome:R-HSA-446214 go.json UDP-glucose dolichyl-phosphate glucosyltransferase activity|UDP-glucose:dolichol phosphate glucosyltransferase activity|UDP-glucose:dolicholphosphoryl glucosyltransferase activity|UDP-glucose:dolichyl monophosphate glucosyltransferase activity|UDP-glucose:dolichyl phosphate glucosyltransferase activity|UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity|UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity|polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity|uridine diphosphoglucose-dolichol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0004581 GO:0004580 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004580 GO:0004598 biolink:MolecularActivity peptidylamidoglycolate lyase activity Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. EC:4.3.2.5|MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN|RHEA:20924 go.json HGAD|PAL|PGL|alpha-hydroxyglycine amidating dealkylase activity|peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity|peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)|peptidylamidoglycolate peptidylamide-lyase activity http://purl.obolibrary.org/obo/GO_0004598 GO:0004597 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004597 GO:0004594 biolink:MolecularActivity pantothenate kinase activity Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. EC:2.7.1.33|MetaCyc:PANTOTHENATE-KIN-RXN|RHEA:16373|Reactome:R-HSA-196857|Reactome:R-HSA-199203 go.json ATP:(R)-pantothenate 4'-phosphotransferase activity|ATP:pantothenate 4'-phosphotransferase activity|D-pantothenate kinase activity|pantothenate kinase (phosphorylating) activity|pantothenic acid kinase activity http://purl.obolibrary.org/obo/GO_0004594 GO:0004593 biolink:MolecularActivity pantothenase activity Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine. EC:3.5.1.22|KEGG_REACTION:R02474|MetaCyc:PANTOTHENASE-RXN|RHEA:12448 go.json (R)-pantothenate amidohydrolase activity|pantothenate amidohydrolase activity|pantothenate hydrolase activity http://purl.obolibrary.org/obo/GO_0004593 GO:0004596 biolink:MolecularActivity peptide alpha-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein. EC:2.3.1.255|Reactome:R-HSA-6814090 go.json N(alpha)-acetyltransferase activity|NAT activity|acetyl-CoA:peptide alpha-N-acetyltransferase activity|acetyl-CoA:peptide nalpha-acetyltransferase activity|amino-terminal amino acid-acetylating enzyme activity|beta-endorphin acetyltransferase activity|nalpha-acetyltransferase activity|peptide acetyltransferase activity|protein N-terminal acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004596 GO:0004595 biolink:MolecularActivity pantetheine-phosphate adenylyltransferase activity Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. EC:2.7.7.3|KEGG_REACTION:R03035|MetaCyc:PANTEPADENYLYLTRAN-RXN|RHEA:19801|Reactome:R-HSA-196754 go.json 3'-dephospho-CoA pyrophosphorylase activity|ATP:pantetheine-4'-phosphate adenylyltransferase activity|ATP:pantetheine-phosphate adenylyltransferase activity|PPAT activity|dephospho-CoA diphosphorylase activity|dephospho-CoA pyrophosphorylase activity|dephospho-coenzyme A pyrophosphorylase activity|pantetheine phosphate adenylyltransferase activity|phosphopantetheine adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0004595 GO:0004590 biolink:MolecularActivity orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. EC:4.1.1.23|KEGG_REACTION:R00965|MetaCyc:OROTPDECARB-RXN|RHEA:11596|Reactome:R-HSA-73564 go.json ODCase activity|OMP decarboxylase activity|OMP-DC|OMPdcase activity|UMP synthase activity|orotate decarboxylase activity|orotate monophosphate decarboxylase activity|orotic decarboxylase activity|orotidine 5'-phosphate decarboxylase activity|orotidine monophosphate decarboxylase activity|orotidine phosphate decarboxylase activity|orotidine-5'-monophosphate decarboxylase activity|orotidine-5'-phosphate carboxy-lyase (UMP-forming)|orotidine-5'-phosphate carboxy-lyase activity|orotidylic acid decarboxylase activity|orotidylic decarboxylase activity|orotodylate decarboxylase activity|uridine 5'-monophosphate synthase activity http://purl.obolibrary.org/obo/GO_0004590 GO:0004592 biolink:MolecularActivity pantoate-beta-alanine ligase activity Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. EC:6.3.2.1|MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN|RHEA:10912 go.json (R)-pantoate:beta-alanine ligase (AMP-forming)|D-pantoate:beta-alanine ligase (AMP-forming)|pantoate-activating enzyme activity|pantoic-activating enzyme activity|pantothenate synthetase activity http://purl.obolibrary.org/obo/GO_0004592 GO:0004591 biolink:MolecularActivity oxoglutarate dehydrogenase (succinyl-transferring) activity Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2. EC:1.2.4.2|MetaCyc:2OXOGLUTDECARB-RXN|RHEA:12188 go.json 2-ketoglutarate dehydrogenase activity|2-oxoglutarate dehydrogenase activity|2-oxoglutarate: lipoate oxidoreductase activity|2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)|2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity|AKGDH activity|OGDC activity|alpha-ketoglutarate dehydrogenase activity|alpha-ketoglutaric acid dehydrogenase activity|alpha-ketoglutaric dehydrogenase activity|alpha-oxoglutarate dehydrogenase activity|ketoglutaric dehydrogenase activity|oxoglutarate decarboxylase activity|oxoglutarate dehydrogenase (lipoamide) activity|oxoglutarate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004591 GO:0004569 biolink:MolecularActivity glycoprotein endo-alpha-1,2-mannosidase activity Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. EC:3.2.1.130|MetaCyc:3.2.1.130-RXN|RHEA:54824|Reactome:R-HSA-964759 go.json endo-alpha-mannosidase activity|endomannosidase activity|glucosyl mannosidase activity|glucosylmannosidase activity|glycoprotein glucosylmannohydrolase activity http://purl.obolibrary.org/obo/GO_0004569 GO:0004568 biolink:MolecularActivity chitinase activity Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. EC:3.2.1.14|MetaCyc:3.2.1.14-RXN|Reactome:R-HSA-6786421 go.json 1,4-beta-poly-N-acetylglucosaminidase activity|beta-1,4-poly-N-acetyl glucosamidinase activity|chitodextrinase activity|poly-beta-glucosaminidase activity|poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0004568 GO:0004565 biolink:MolecularActivity beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. EC:3.2.1.23|MetaCyc:3.2.1.23-RXN|MetaCyc:BGALACT-PWY|Reactome:R-HSA-1605624|Reactome:R-HSA-1606312|Reactome:R-HSA-1630306|Reactome:R-HSA-1793217|Reactome:R-HSA-2090079|Reactome:R-HSA-2265534|Reactome:R-HSA-9036061|Reactome:R-HSA-9840795 go.json beta-D-galactanase activity|beta-D-galactoside galactohydrolase activity|beta-D-lactosidase activity|beta-lactosidase activity|exo-(1->4)-beta-D-galactanase activity|hydrolact http://purl.obolibrary.org/obo/GO_0004565 GO:0004564 biolink:MolecularActivity beta-fructofuranosidase activity Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. EC:3.2.1.26|MetaCyc:RXN-9985 go.json acid invertase activity|alkaline invertase activity|beta-D-fructofuranoside fructohydrolase activity|beta-fructosidase activity|beta-h-fructosidase activity|fructosylinvertase activity|glucosucrase activity|invertase activity|invertin activity|maxinvert L 1000 activity|saccharase activity http://purl.obolibrary.org/obo/GO_0004564 GO:0004567 biolink:MolecularActivity beta-mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. EC:3.2.1.25|MetaCyc:3.2.1.25-RXN|Reactome:R-HSA-8853710 go.json beta-D-mannosidase activity|beta-D-mannoside mannohydrolase activity|beta-mannoside mannohydrolase activity|exo-beta-D-mannanase activity|mannanase activity|mannase activity http://purl.obolibrary.org/obo/GO_0004567 GO:0004566 biolink:MolecularActivity beta-glucuronidase activity Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. EC:3.2.1.31|MetaCyc:BETA-GLUCURONID-RXN|RHEA:17633|Reactome:R-HSA-1678854|Reactome:R-HSA-2162226|Reactome:R-HSA-2162227|Reactome:R-HSA-2318373|Reactome:R-HSA-9036068|Reactome:R-HSA-9036070 go.json beta-D-glucuronoside glucuronosohydrolase activity|beta-glucuronide glucuronohydrolase activity|exo-beta-D-glucuronidase activity|glucuronidase activity|ketodase activity http://purl.obolibrary.org/obo/GO_0004566 GO:0004561 biolink:MolecularActivity alpha-N-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. EC:3.2.1.50|MetaCyc:3.2.1.50-RXN|Reactome:R-HSA-1678742|Reactome:R-HSA-2090038|Reactome:R-HSA-2263496|Reactome:R-HSA-9036052 go.json N-acetyl-alpha-D-glucosaminidase activity|N-acetyl-alpha-glucosaminidase activity|NAG activity|alpha-D-2-acetamido-2-deoxyglucosidase activity|alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity|alpha-acetylglucosaminidase activity http://purl.obolibrary.org/obo/GO_0004561 GO:0004560 biolink:MolecularActivity alpha-L-fucosidase activity Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. EC:3.2.1.51|MetaCyc:ALPHA-L-FUCOSIDASE-RXN|RHEA:12288|Reactome:R-HSA-5693807 go.json alpha-L-fucoside fucohydrolase activity|alpha-fucosidase activity http://purl.obolibrary.org/obo/GO_0004560 GO:0004563 biolink:MolecularActivity beta-N-acetylhexosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. EC:3.2.1.52|MetaCyc:3.2.1.52-RXN|Reactome:R-HSA-1605595|Reactome:R-HSA-1605632|Reactome:R-HSA-1638053|Reactome:R-HSA-2105001|Reactome:R-HSA-2162225|Reactome:R-HSA-3656259|Reactome:R-HSA-3662344|Reactome:R-HSA-9035976|Reactome:R-HSA-9035978|Reactome:R-HSA-9035982|Reactome:R-HSA-9035983|Reactome:R-HSA-9638075|Reactome:R-HSA-9638076|Reactome:R-HSA-9638078|Reactome:R-HSA-9840833|Reactome:R-HSA-9840884 go.json N-acetyl-beta-D-hexosaminidase activity|N-acetyl-beta-glucosaminidase activity|N-acetyl-beta-hexosaminidase activity|N-acetylhexosaminidase activity|beta-D-N-acetylhexosaminidase activity|beta-D-hexosaminidase activity|beta-N-acetyl-D-hexosaminidase activity|beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity|beta-acetylaminodeoxyhexosidase activity|beta-acetylhexosaminidinase activity|beta-hexosaminidase activity|hexosaminidase A http://purl.obolibrary.org/obo/GO_0004563 GO:0004562 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004562 GO:0004579 biolink:MolecularActivity dolichyl-diphosphooligosaccharide-protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. EC:2.4.99.18|MetaCyc:2.4.1.119-RXN|RHEA:22980|Reactome:R-HSA-446209|Reactome:R-HSA-9694793 go.json asparagine N-glycosyltransferase activity|dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity|dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity|dolichyldiphosphooligosaccharide-protein glycosyltransferase activity|dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity|dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity|dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity|oligomannosyltransferase activity http://purl.obolibrary.org/obo/GO_0004579 GO:0004576 biolink:MolecularActivity oligosaccharyl transferase activity Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. go.json oligosaccharide transferase activity http://purl.obolibrary.org/obo/GO_0004576 GO:0004575 biolink:MolecularActivity sucrose alpha-glucosidase activity Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. EC:3.2.1.48|KEGG_REACTION:R00802|MetaCyc:3.2.1.48-RXN|RHEA:33795|Reactome:R-HSA-189069|Reactome:R-HSA-5659926 go.json alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis|beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis|intestinal sucrase activity|sucrase activity|sucrase(invertase)|sucrase-isomaltase activity|sucrose alpha-D-glucohydrolase activity|sucrose alpha-glucohydrolase activity|sucrose hydrolysis|sucrose-alpha-D-glucohydrolase activity http://purl.obolibrary.org/obo/GO_0004575 GO:0004578 biolink:MolecularActivity chitobiosyldiphosphodolichol beta-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol. EC:2.4.1.142|MetaCyc:2.4.1.142-RXN|RHEA:13865|Reactome:R-HSA-446218|Reactome:R-HSA-4549382 go.json GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity|GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity|guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0004578 GO:0004577 biolink:MolecularActivity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. EC:2.4.1.141|MetaCyc:2.4.1.141-RXN|RHEA:23380|Reactome:R-HSA-446207|Reactome:R-HSA-5633241 go.json N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity|UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity|UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0004577 GO:0004572 biolink:MolecularActivity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). EC:3.2.1.114|MetaCyc:3.2.1.114-RXN|RHEA:56052|Reactome:R-HSA-975814 go.json 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity|GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity|Golgi alpha-mannosidase II|ManII activity|alpha-(1,3/6)-mannosidase activity|alpha-D-mannosidase II|alpha-mannosidase II|exo-1,3-1,6-alpha-mannosidase activity|mannosidase II activity|mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity|mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity|mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity http://purl.obolibrary.org/obo/GO_0004572 GO:0004571 biolink:MolecularActivity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. EC:3.2.1.113|KEGG_REACTION:R05982|KEGG_REACTION:R06722|MetaCyc:RXN-18910|MetaCyc:RXN-18911|Reactome:R-HSA-4793949|Reactome:R-HSA-6782685|Reactome:R-HSA-901024|Reactome:R-HSA-901036|Reactome:R-HSA-901039|Reactome:R-HSA-901074|Reactome:R-HSA-9036008|Reactome:R-HSA-9036011|Reactome:R-HSA-9036012|Reactome:R-HSA-964737|Reactome:R-HSA-964825|Reactome:R-HSA-964830|Reactome:R-HSA-9696807 go.json 1,2-alpha-mannosidase|1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|Man9-mannosidase activity|ManI activity|exo-alpha-1,2-mannanase activity|glycoprotein processing mannosidase I|mannose-9 processing alpha-mannosidase activity|mannosidase 1A activity|mannosidase 1B activity|mannosidase I http://purl.obolibrary.org/obo/GO_0004571 GO:0004574 biolink:MolecularActivity oligo-1,6-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. EC:3.2.1.10|MetaCyc:3.2.1.10-RXN go.json alpha-limit dextrinase activity|alpha-methylglucosidase activity|dextrin 6-glucanohydrolase activity|dextrin 6alpha-glucanohydrolase activity|exo-oligo-1,6-glucosidase activity|isomaltase activity|limit dextrinase|oligosaccharide alpha-1,6-glucohydrolase activity|oligosaccharide alpha-1,6-glucosidase activity|sucrase-isomaltase activity http://purl.obolibrary.org/obo/GO_0004574 GO:0004573 biolink:MolecularActivity Glc3Man9GlcNAc2 oligosaccharide glucosidase activity Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). EC:3.2.1.106|MetaCyc:3.2.1.106-RXN|RHEA:55988|Reactome:R-HSA-4793947|Reactome:R-HSA-532678|Reactome:R-HSA-9694364 go.json mannosyl-oligosaccharide glucohydrolase activity|mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity|mannosyl-oligosaccharide glucosidase activity|processing A-glucosidase I activity|trimming glucosidase I http://purl.obolibrary.org/obo/GO_0004573 GO:0004549 biolink:MolecularActivity tRNA-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. Reactome:R-HSA-5696813|Reactome:R-HSA-5696815|Reactome:R-HSA-6785722|Reactome:R-HSA-6786854 go.json tRNA-specific RNase activity http://purl.obolibrary.org/obo/GO_0004549 GO:0004540 biolink:MolecularActivity RNA nuclease activity Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. go.json https://github.com/geneontology/go-ontology/issues/24408|ribonuclease activity http://purl.obolibrary.org/obo/GO_0004540 GO:0004558 biolink:MolecularActivity alpha-1,4-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. EC:3.2.1.20|MetaCyc:MALTODEXGLUCOSID-RXN|Reactome:R-HSA-189053|Reactome:R-HSA-189102|Reactome:R-HSA-191101|Reactome:R-HSA-191108|Reactome:R-HSA-191116|Reactome:R-HSA-5659861|Reactome:R-HSA-5659879|Reactome:R-HSA-5659899|Reactome:R-HSA-5659922 go.json acid maltase activity|alpha-D-glucosidase activity|alpha-D-glucoside glucohydrolase activity|alpha-glucopyranosidase activity|alpha-glucosidase II|alpha-glucoside hydrolase activity|glucoinvertase activity|glucosidoinvertase activity|glucosidosucrase activity|lysosomal alpha-glucosidase activity|maltase-glucoamylase activity http://purl.obolibrary.org/obo/GO_0004558 GO:0004557 biolink:MolecularActivity alpha-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. EC:3.2.1.22|MetaCyc:ALPHAGALACTOSID-RXN|Reactome:R-HSA-1605736|Reactome:R-HSA-9841189 go.json alpha-D-galactosidase activity|melibiase activity http://purl.obolibrary.org/obo/GO_0004557 GO:0004559 biolink:MolecularActivity alpha-mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. EC:3.2.1.24|MetaCyc:3.2.1.24-RXN|Reactome:R-HSA-6799545|Reactome:R-HSA-8853686|Reactome:R-HSA-9694656 go.json 1,2-alpha-D-mannosidase activity|1,2-alpha-mannosidase|alpha-D-mannopyranosidase activity|alpha-D-mannosidase activity|alpha-D-mannoside mannohydrolase activity|exo-alpha-mannosidase activity|p-nitrophenyl-alpha-mannosidase activity http://purl.obolibrary.org/obo/GO_0004559 GO:0004553 biolink:MolecularActivity hydrolase activity, hydrolyzing O-glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond. EC:3.2.1.-|Reactome:R-HSA-5694563|Reactome:R-HSA-6786652|Reactome:R-HSA-9661820 go.json O-glucosyl hydrolase activity http://purl.obolibrary.org/obo/GO_0004553 GO:0004556 biolink:MolecularActivity alpha-amylase activity Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. EC:3.2.1.1|MetaCyc:ALPHA-AMYL-RXN|MetaCyc:RXN-1823|MetaCyc:RXN-1825|Reactome:R-HSA-188979|Reactome:R-HSA-191114 go.json 1,4-alpha-D-glucan glucanohydrolase activity|alpha amylase activity|alpha-amylase activity (releasing maltohexaose)|endoamylase activity|glycogenase activity|taka-amylase A http://purl.obolibrary.org/obo/GO_0004556 GO:0004555 biolink:MolecularActivity alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. EC:3.2.1.28|MetaCyc:TREHALA-RXN|RHEA:32675|Reactome:R-HSA-188985 go.json alpha,alpha-trehalose glucohydrolase activity http://purl.obolibrary.org/obo/GO_0004555 GO:0004550 biolink:MolecularActivity nucleoside diphosphate kinase activity Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. EC:2.7.4.6|MetaCyc:NUCLEOSIDE-DIP-KIN-RXN|Reactome:R-HSA-2162096|Reactome:R-HSA-482619|Reactome:R-HSA-482621|Reactome:R-HSA-482804|Reactome:R-HSA-482812|Reactome:R-HSA-6806877|Reactome:R-HSA-9748969|Reactome:R-HSA-9748999|Reactome:R-HSA-9755013 go.json ATP:nucleoside-diphosphate phosphotransferase activity|NDK activity|UDP kinase activity|nucleoside 5'-diphosphate kinase activity|nucleoside 5'-diphosphate phosphotransferase activity|nucleoside diphosphate (UDP) kinase activity|nucleoside diphosphokinase activity|nucleoside-diphosphate kinase activity|nucleotide phosphate kinase activity|uridine diphosphate kinase activity http://purl.obolibrary.org/obo/GO_0004550 GO:0004552 biolink:MolecularActivity octanol dehydrogenase activity Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH. EC:1.1.1.73|KEGG_REACTION:R02878|MetaCyc:OCTANOL-DEHYDROGENASE-RXN|RHEA:24620 go.json 1-octanol dehydrogenase activity|octanol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004552 GO:0004551 biolink:MolecularActivity dinucleotide phosphatase activity Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN|Reactome:R-HSA-196955 go.json dinucleotide nucleotidohydrolase activity|nucleotide diphosphatase activity|nucleotide pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0004551 GO:0102991 biolink:MolecularActivity myristoyl-CoA hydrolase activity Catalysis of the reaction: myristoyl-CoA + H2O = H+ + tetradecanoate + coenzyme A. EC:3.1.2.2|MetaCyc:RXN-9626|RHEA:40119 go.json http://purl.obolibrary.org/obo/GO_0102991 GO:0102990 biolink:MolecularActivity 5-n-alk(en)ylresorcinol O-methyltransferase activity Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine. MetaCyc:RXN-9619|RHEA:26325 go.json http://purl.obolibrary.org/obo/GO_0102990 GO:0102993 biolink:MolecularActivity linolenate delta15 desaturase activity Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor = 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor. MetaCyc:RXN-9667|RHEA:46408 go.json http://purl.obolibrary.org/obo/GO_0102993 GO:0102992 biolink:MolecularActivity 2-methylbutyronitrile hydroxylase activity Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 = H2O + NADP + 2-hydroxy-2-methylbutyronitrile. MetaCyc:RXN-9642|RHEA:51948 go.json http://purl.obolibrary.org/obo/GO_0102992 GO:0102995 biolink:MolecularActivity angelicin synthase activity Catalysis of the reaction: columbianetin + NADPH + O2 + H+ = angelicin + acetone + NADP + 2 H2O. EC:1.14.14.148|MetaCyc:RXN-9689|RHEA:27481 go.json http://purl.obolibrary.org/obo/GO_0102995 GO:0102997 biolink:MolecularActivity progesterone 5beta- reductase activity Catalysis of the reaction: H+ + progesterone + NADPH = 5beta-pregnane-3,20-dione + NADP. MetaCyc:RXN-9726 go.json http://purl.obolibrary.org/obo/GO_0102997 GO:0102996 biolink:MolecularActivity beta,beta digalactosyldiacylglycerol galactosyltransferase activity Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol = a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol. EC:2.4.1.184|MetaCyc:RXN-9721 go.json http://purl.obolibrary.org/obo/GO_0102996 GO:0102999 biolink:MolecularActivity UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene = 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+. MetaCyc:RXN-9743 go.json http://purl.obolibrary.org/obo/GO_0102999 GO:0102998 biolink:MolecularActivity 4-sulfomuconolactone hydrolase activity Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O = maleylacetate + sulfite + 2 H+. EC:3.1.1.92|MetaCyc:RXN-9733|RHEA:33711 go.json http://purl.obolibrary.org/obo/GO_0102998 GO:0038096 biolink:BiologicalProcess Fc-gamma receptor signaling pathway involved in phagocytosis An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. go.json Fc gamma receptor-dependent phagocytosis|Fc-gamma receptor signalling pathway involved in phagocytosis|Fcgamma receptor-mediated phagocytosis|IgG-mediated phagocytosis http://purl.obolibrary.org/obo/GO_0038096 GO:0038095 biolink:BiologicalProcess Fc-epsilon receptor signaling pathway The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. go.json Fc-epsilon receptor signalling pathway http://purl.obolibrary.org/obo/GO_0038095 GO:0038098 biolink:BiologicalProcess sequestering of BMP from receptor via BMP binding Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor. go.json extracellular sequestering of BMP|extracellular sequestering of bone morphogenetic protein http://purl.obolibrary.org/obo/GO_0038098 GO:0038097 biolink:BiologicalProcess positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. go.json Fc epsilon RI-dependent mast cell activation|Fc epsilon RI-mediated mast cell activation|positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway http://purl.obolibrary.org/obo/GO_0038097 GO:0038099 biolink:BiologicalProcess nodal receptor complex assembly The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals). go.json ActRIIB.ALK4.EGF-CFC complex formation|nodal receptor complex formation http://purl.obolibrary.org/obo/GO_0038099 GO:0038090 biolink:BiologicalProcess positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. go.json VEGF/PDGFR-induced cell migration|positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway|positive regulation of cell migration by VEGF/PDGFR signaling pathway http://purl.obolibrary.org/obo/GO_0038090 GO:0038092 biolink:BiologicalProcess nodal signaling pathway The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json nodal signaling|nodal signalling pathway http://purl.obolibrary.org/obo/GO_0038092 GO:0038091 biolink:BiologicalProcess positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation. go.json VEGF-A-induced cell proliferation|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway|positive regulation of cell proliferation by VEGF/PDGFR signaling pathway http://purl.obolibrary.org/obo/GO_0038091 GO:0038094 biolink:BiologicalProcess Fc-gamma receptor signaling pathway The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. go.json Fc-gamma receptor signalling pathway http://purl.obolibrary.org/obo/GO_0038094 GO:0038093 biolink:BiologicalProcess Fc receptor signaling pathway The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. go.json Fc receptor signalling pathway http://purl.obolibrary.org/obo/GO_0038093 GO:0038085 biolink:MolecularActivity vascular endothelial growth factor binding Binding to a vascular endothelial growth factor. go.json VEGF binding http://purl.obolibrary.org/obo/GO_0038085 GO:0038084 biolink:BiologicalProcess vascular endothelial growth factor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json VEGF signaling|VEGF-activated signaling pathway|vascular endothelial growth factor signalling pathway http://purl.obolibrary.org/obo/GO_0038084 GO:0038087 biolink:BiologicalProcess VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json VEGF-A/PDGFRalpha signaling|VEGF-activated PDGFRalpha signalling pathway|VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway|VEGF/PDGFRalpha signaling pathway|vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway http://purl.obolibrary.org/obo/GO_0038087 GO:0038086 biolink:BiologicalProcess VEGF-activated platelet-derived growth factor receptor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json VEGF-A/PDGFR signaling|VEGF-activated PDGFR signalling pathway|VEGF-activated platelet-derived growth factor receptor signalling pathway|VEGF/PDGFR signaling pathway|vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038086 GO:0038089 biolink:BiologicalProcess positive regulation of cell migration by vascular endothelial growth factor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. go.json VEGF-A-induced cell migration|VEGF-induced cell migration|positive regulation of cell migration by VEGF signaling pathway|positive regulation of cell migration by vascular endothelial growth factor signalling pathway http://purl.obolibrary.org/obo/GO_0038089 GO:0038088 biolink:BiologicalProcess VEGF-activated platelet-derived growth factor receptor-beta signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json VEGF-A/PDGFRbeta signaling|VEGF-activated PDGFRbeta signalling pathway|VEGF-activated platelet-derived growth factor receptor-beta signalling pathway|VEGF/PDGFRbeta signaling pathway|vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway http://purl.obolibrary.org/obo/GO_0038088 GO:0038081 biolink:MolecularActivity obsolete MAP kinase kinase kinase activity involved in osmosensory signaling pathway OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway. go.json MAP kinase kinase kinase activity involved in osmosensory signalling pathway|MAP3K activity involved in osmosensory signaling pathway|MAPKKK activity involved in osmosensory signaling pathway True http://purl.obolibrary.org/obo/GO_0038081 GO:0038080 biolink:MolecularActivity obsolete MAP kinase kinase activity involved in osmosensory signaling pathway OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway. go.json MAP kinase kinase activity involved in osmosensory signalling pathway|MAP2K activity involved in osmosensory signaling pathway|MAPKK activity involved in osmosensory signaling pathway True http://purl.obolibrary.org/obo/GO_0038080 GO:0038083 biolink:BiologicalProcess peptidyl-tyrosine autophosphorylation The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. go.json RTK autophosphorylation|receptor tyrosine kinase autophosphorylation|tyrosine autophosphorylation http://purl.obolibrary.org/obo/GO_0038083 gocheck_do_not_annotate GO:0038082 biolink:MolecularActivity obsolete MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway. go.json Hog1 phosphatase activity|MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway|MAPK phosphatase activity involved in regulation of osmosensory signaling pathway True http://purl.obolibrary.org/obo/GO_0038082 GO:0038074 biolink:MolecularActivity obsolete MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion. go.json MAPK phosphatase activity involved in regulation of conjugation with cellular fusion True http://purl.obolibrary.org/obo/GO_0038074 GO:0038073 biolink:MolecularActivity obsolete MAP kinase kinase kinase activity involved in conjugation with cellular fusion OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis. go.json MAP3K activity involved in conjugation with cellular fusion|MAPKKK activity involved in conjugation with cellular fusion True http://purl.obolibrary.org/obo/GO_0038073 GO:0038076 biolink:MolecularActivity obsolete MAP kinase kinase activity involved in innate immune response OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response. go.json MAP2K activity involved in innate immune response|MAPKK activity involved in innate immune response True http://purl.obolibrary.org/obo/GO_0038076 GO:0038075 biolink:MolecularActivity obsolete MAP kinase activity involved in innate immune response OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response. go.json MAPK activity involved in innate immune response True http://purl.obolibrary.org/obo/GO_0038075 GO:0038078 biolink:MolecularActivity obsolete MAP kinase phosphatase activity involved in regulation of innate immune response OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response. go.json MAPK phosphatase activity involved in regulation of innate immune response True http://purl.obolibrary.org/obo/GO_0038078 GO:0038077 biolink:MolecularActivity obsolete MAP kinase kinase kinase activity involved in innate immune response OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response. go.json MAP3K activity involved in innate immune response|MAPKKK activity involved in innate immune response True http://purl.obolibrary.org/obo/GO_0038077 GO:0038079 biolink:MolecularActivity obsolete MAP kinase activity involved in osmosensory signaling pathway OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway. go.json MAP kinase activity involved in osmosensory signalling pathway|MAPK activity involved in osmosensory signaling pathway True http://purl.obolibrary.org/obo/GO_0038079 GO:0038070 biolink:MolecularActivity obsolete MAP kinase kinase kinase activity involved in cell wall organization or biogenesis OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis. go.json MAP kinase kinase kinase activity involved in cell wall biogenesis|MAP3K activity involved in cell wall integrity|MAPKKK activity involved in cell wall integrity True http://purl.obolibrary.org/obo/GO_0038070 GO:0038072 biolink:MolecularActivity obsolete MAP kinase kinase activity involved in conjugation with cellular fusion OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion. go.json MAP2K activity involved in conjugation with cellular fusion|MAPKK activity involved in conjugation with cellular fusion True http://purl.obolibrary.org/obo/GO_0038072 GO:0038071 biolink:MolecularActivity obsolete MAP kinase activity involved in conjugation with cellular fusion OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion. go.json MAPK activity involved in conjugation with cellular fusion True http://purl.obolibrary.org/obo/GO_0038071 GO:0038063 biolink:BiologicalProcess collagen-activated tyrosine kinase receptor signaling pathway The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json DDR signaling pathway|collagen-activated RTK signaling pathway|collagen-activated tyrosine kinase receptor signalling pathway|discoidin domain receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038063 GO:0038062 biolink:MolecularActivity protein tyrosine kinase collagen receptor activity Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. go.json collagen RTK activity|discoidin domain receptor http://purl.obolibrary.org/obo/GO_0038062 GO:0038065 biolink:BiologicalProcess collagen-activated signaling pathway The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json collagen-activated signalling pathway http://purl.obolibrary.org/obo/GO_0038065 GO:0038064 biolink:MolecularActivity collagen receptor activity Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json transmembrane collagen receptor activity http://purl.obolibrary.org/obo/GO_0038064 GO:0038067 biolink:MolecularActivity obsolete MAP kinase activity involved in cell wall organization or biogenesis OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis. go.json MAP kinase activity involved in cell wall biogenesis|MAP kinase activity involved in cell wall integrity|MAPK activity involved in cell wall biogenesis True http://purl.obolibrary.org/obo/GO_0038067 GO:0038066 biolink:BiologicalProcess p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. go.json p38 MAPK cascade|p38 cascade http://purl.obolibrary.org/obo/GO_0038066 GO:0038069 biolink:MolecularActivity obsolete MAP kinase phosphatase activity involved in regulation of cell wall biogenesis OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis. go.json Mpk1 phosphatase activity|Slt2 phosphatase activity True http://purl.obolibrary.org/obo/GO_0038069 GO:0038068 biolink:MolecularActivity obsolete MAP kinase kinase activity involved in cell wall organization or biogenesis OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis. go.json MAP kinase kinase activity involved in cell wall biogenesis|MAP2K activity involved in cell wall integrity|MAPKK activity involved in cell wall integrity True http://purl.obolibrary.org/obo/GO_0038068 GO:0038061 biolink:BiologicalProcess non-canonical NF-kappaB signal transduction The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). go.json NIK-IKK kinase cascade|NIK-IKK signaling pathway|NIK-IKK-alpha cascade|NIK/NF-kappaB cascade|NIK/NF-kappaB signal transduction|NIK/NF-kappaB signaling|non-canonical NF-KB signaling|noncanonical NF-kappaB signaling|noncanonical nuclear factor kappaB (NF-kappaB) pathway|p52-dependent NF-kappaB signaling http://purl.obolibrary.org/obo/GO_0038061 GO:0038060 biolink:BiologicalProcess nitric oxide-cGMP-mediated signaling pathway Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. go.json NO-cGMP signaling pathway|canonical nitric oxide signaling|classical nitric oxide signaling|nitric oxide-cGMP-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038060 GO:0102951 biolink:MolecularActivity indole-3-acetyl-phenylalanine synthetase activity Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid. MetaCyc:RXN-9084 go.json http://purl.obolibrary.org/obo/GO_0102951 GO:0102950 biolink:MolecularActivity indole-3-acetyl-valine synthetase activity Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid. MetaCyc:RXN-9083 go.json http://purl.obolibrary.org/obo/GO_0102950 GO:0102953 biolink:MolecularActivity hypoglycin A gamma-glutamyl transpeptidase activity Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B. MetaCyc:RXN-9157 go.json http://purl.obolibrary.org/obo/GO_0102953 GO:0102952 biolink:MolecularActivity UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP. MetaCyc:RXN-91|RHEA:57708 go.json http://purl.obolibrary.org/obo/GO_0102952 GO:0102955 biolink:MolecularActivity S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+. EC:2.1.1.163|MetaCyc:RXN-9191|RHEA:33255 go.json http://purl.obolibrary.org/obo/GO_0102955 GO:0102954 biolink:MolecularActivity dalcochinase activity Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O = dalcochinin + D-glucopyranose. MetaCyc:RXN-9162 go.json http://purl.obolibrary.org/obo/GO_0102954 GO:0038059 biolink:CellularComponent IKKalpha-IKKalpha complex A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits. go.json IKKalpha homodimer|IKKalpha homodimeric complex|IKKalpha-IKKalpha protein complex|IkappaB kinase alpha homodimer|IkappaB kinase-alpha homodimer http://purl.obolibrary.org/obo/GO_0038059 GO:0102956 biolink:MolecularActivity UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP. MetaCyc:RXN-92|RHEA:57712 go.json http://purl.obolibrary.org/obo/GO_0102956 GO:0038052 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038052 GO:0038051 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038051 GO:0038054 biolink:MolecularActivity G protein-coupled estrogen receptor activity Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G-protein coupled estrogen receptor activity|estrogen receptor activity http://purl.obolibrary.org/obo/GO_0038054 GO:0038053 biolink:MolecularActivity obsolete transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding OBSOLETE. Combining with estrogen and transmitting the signal to the transcriptional machinery by binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements. go.json estrogen nuclear receptor activity|estrogen-activated RNA polymerase II transcription factor binding transcription factor activity True http://purl.obolibrary.org/obo/GO_0038053 GO:0038056 biolink:BiologicalProcess obsolete negative regulation of BMP signaling pathway by negative regulation of BMP secretion OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell. go.json negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion|negative regulation of BMP signalling pathway by negative regulation of BMP secretion True http://purl.obolibrary.org/obo/GO_0038056 GO:0038055 biolink:BiologicalProcess BMP secretion The controlled release of a member of the BMP family of proteins from a cell. go.json BMP protein secretion|bone morphogenetic protein secretion http://purl.obolibrary.org/obo/GO_0038055 GO:0038058 biolink:MolecularActivity TNFSF11 receptor activity Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function. go.json RANKL receptor activity|tumor necrosis factor ligand superfamily member 11 receptor activity http://purl.obolibrary.org/obo/GO_0038058 GO:0038057 biolink:MolecularActivity TNFSF11 binding Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family. go.json CD254 binding|ODF binding|OPGL binding|RANKL binding|TNF-related activation-induced cytokine binding|TRANCE binding|osteoclast differentiation factor binding|osteoprotegerin ligand binding|receptor activator of nuclear factor kappa-B ligand binding|tumor necrosis factor (ligand) superfamily member 11 binding|tumor necrosis factor ligand superfamily member 11 binding|tumor necrosis factor superfamily member 11 binding http://purl.obolibrary.org/obo/GO_0038057 GO:0038050 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038050 GO:0102960 biolink:MolecularActivity momilactone-A synthase activity Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H. EC:1.1.1.295|MetaCyc:RXN-9290|RHEA:25367 go.json http://purl.obolibrary.org/obo/GO_0102960 GO:0102962 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102962 GO:0102961 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102961 GO:0102964 biolink:MolecularActivity S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine = H+ + magnoflorine + S-adenosyl-L-homocysteine. MetaCyc:RXN-9315|RHEA:51524 go.json http://purl.obolibrary.org/obo/GO_0102964 GO:0102963 biolink:MolecularActivity (S)-corytuberine synthase activity Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 = (S)-corytuberine + NADP + 2 H2O. EC:1.14.19.51|MetaCyc:RXN-9314|RHEA:51540 go.json http://purl.obolibrary.org/obo/GO_0102963 GO:0102966 biolink:MolecularActivity arachidoyl-CoA:1-dodecanol O-acyltransferase activity Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A. EC:2.3.1.75|MetaCyc:RXN-9356 go.json http://purl.obolibrary.org/obo/GO_0102966 GO:0102965 biolink:MolecularActivity alcohol-forming long-chain fatty acyl-CoA reductase activity Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons. EC:1.2.1.84|MetaCyc:RXN-9344|RHEA:52716 go.json alcohol-forming fatty acyl-CoA reductase activity http://purl.obolibrary.org/obo/GO_0102965 GO:0038049 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038049 GO:0102968 biolink:MolecularActivity 10-hydroxygeranial oxidoreductase activity Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP = (6E)-8-oxogeranial + NADPH + H+. MetaCyc:RXN-9369|RHEA:32611 go.json http://purl.obolibrary.org/obo/GO_0102968 GO:0038048 biolink:MolecularActivity dynorphin receptor activity Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin. go.json kappa-opioid receptor activity http://purl.obolibrary.org/obo/GO_0038048 GO:0102967 biolink:MolecularActivity 10-hydroxygeraniol oxidoreductase activity Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP = (6E)-8-hydroxygeranial + NADPH + H+. MetaCyc:RXN-9367|RHEA:32607 go.json http://purl.obolibrary.org/obo/GO_0102967 GO:0102969 biolink:MolecularActivity 10-oxogeraniol oxidoreductase activity Catalysis of the reaction: (6E)-8-oxogeraniol + NADP = (6E)-8-oxogeranial + NADPH + H+. MetaCyc:RXN-9370|RHEA:32615 go.json http://purl.obolibrary.org/obo/GO_0102969 GO:0038041 biolink:BiologicalProcess cross-receptor inhibition within G protein-coupled receptor heterodimer Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit. go.json cross-receptor inhibition within G-protein coupled receptor heterodimer http://purl.obolibrary.org/obo/GO_0038041 gocheck_do_not_annotate GO:0038040 biolink:BiologicalProcess obsolete cross-receptor activation within G-protein coupled receptor heterodimer OBSOLETE. Activation of one protomer of a consequence of a G protein-coupled (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter. go.json True http://purl.obolibrary.org/obo/GO_0038040 GO:0038043 biolink:BiologicalProcess interleukin-5-mediated signaling pathway The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-5-mediated signaling pathway|interleukin-5-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038043 GO:0038042 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038042 GO:0038045 biolink:CellularComponent large latent transforming growth factor-beta complex A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors. go.json LLC|large latent complex http://purl.obolibrary.org/obo/GO_0038045 GO:0038044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038044 GO:0038047 biolink:MolecularActivity morphine receptor activity Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein. go.json mu-opioid receptor activity http://purl.obolibrary.org/obo/GO_0038047 GO:0038046 biolink:MolecularActivity G protein-coupled enkephalin receptor activity Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body. go.json delta-opioid receptor activity|enkephalin receptor activity http://purl.obolibrary.org/obo/GO_0038046 GO:0014070 biolink:BiologicalProcess response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. go.json response to organic cyclic substance http://purl.obolibrary.org/obo/GO_0014070 GO:0102971 biolink:MolecularActivity phosphinothricin N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + phosphinothricin = H+ + coenzyme A(4-) + N-acetylphosphinatothricinate. EC:2.3.1.183|MetaCyc:RXN-9382|RHEA:12597 go.json http://purl.obolibrary.org/obo/GO_0102971 GO:0102970 biolink:MolecularActivity 7-deoxyloganetic acid glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate = H+ + 7-deoxyloganate + UDP. EC:2.4.1.323|MetaCyc:RXN-9372|RHEA:39895 go.json http://purl.obolibrary.org/obo/GO_0102970 GO:0102973 biolink:MolecularActivity norsolorinate anthrone synthase activity Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]. EC:2.3.1.221|MetaCyc:RXN-9479|RHEA:35179 go.json norsolorinic acid synthase http://purl.obolibrary.org/obo/GO_0102973 GO:0102972 biolink:MolecularActivity gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming) Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide. MetaCyc:RXN-947 go.json http://purl.obolibrary.org/obo/GO_0102972 GO:0102975 biolink:MolecularActivity versiconal hemiacetal acetate reductase activity Catalysis of the reaction: versiconol acetate + NADP = versiconal hemiacetal acetate + NADPH. EC:1.1.1.353|MetaCyc:RXN-9490|RHEA:35695 go.json http://purl.obolibrary.org/obo/GO_0102975 GO:0102974 biolink:MolecularActivity hydroxyversicolorone reductase activity Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH. EC:1.1.1.353|MetaCyc:RXN-9489|RHEA:35691 go.json http://purl.obolibrary.org/obo/GO_0102974 GO:0102977 biolink:MolecularActivity nitrilotriacetate monooxygenase activity (FMN-dependent) Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN. EC:1.14.14.10|MetaCyc:RXN-9508|RHEA:31359 go.json http://purl.obolibrary.org/obo/GO_0102977 GO:0102976 biolink:MolecularActivity versiconal reductase activity Catalysis of the reaction: versiconol + NADP = versiconal hemiacetal + NADPH + H+. EC:1.1.1.353|MetaCyc:RXN-9491|RHEA:35699 go.json http://purl.obolibrary.org/obo/GO_0102976 GO:0038038 biolink:CellularComponent G protein-coupled receptor homodimeric complex A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor. go.json G-protein coupled receptor homodimer|G-protein coupled receptor homodimeric complex|GPCR homodimer http://purl.obolibrary.org/obo/GO_0038038 GO:0102979 biolink:MolecularActivity homofuraneol oxidoreductase activity Catalysis of the reaction: homofuraneol + NADP = (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. MetaCyc:RXN-9564|RHEA:53944 go.json http://purl.obolibrary.org/obo/GO_0102979 GO:0038037 biolink:CellularComponent G protein-coupled receptor dimeric complex A protein complex that contains two G protein-coupled receptors. go.json G-protein coupled receptor dimer|G-protein coupled receptor dimeric complex|GPCR dimer http://purl.obolibrary.org/obo/GO_0038037 GO:0102978 biolink:MolecularActivity furaneol oxidoreductase activity Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP = 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+. EC:1.3.1.105|MetaCyc:RXN-9563|RHEA:39111 go.json http://purl.obolibrary.org/obo/GO_0102978 GO:0014069 biolink:CellularComponent postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. NIF_Subcellular:sao1196688972|Wikipedia:Postsynaptic_density go.json neuronal postsynaptic density|post synaptic density|post-synaptic density|postsynaptic density of dendrite http://purl.obolibrary.org/obo/GO_0014069 goslim_synapse GO:0014068 biolink:BiologicalProcess obsolete positive regulation of phosphatidylinositol 3-kinase signaling OBSOLETE. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. go.json activation of phosphoinositide 3-kinase cascade|positive regulation of PI 3-kinase cascade|positive regulation of PI3K cascade|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of phosphoinositide 3-kinase cascade|stimulation of phosphatidylinositol 3-kinase cascade|up regulation of phosphatidylinositol 3-kinase cascade|up-regulation of phosphatidylinositol 3-kinase cascade|upregulation of phosphatidylinositol 3-kinase cascade True http://purl.obolibrary.org/obo/GO_0014068 GO:0038039 biolink:CellularComponent G protein-coupled receptor heterodimeric complex A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR. go.json G-protein coupled receptor heterodimer|G-protein coupled receptor heterodimeric complex|GPCR heterodimer http://purl.obolibrary.org/obo/GO_0038039 GO:0014063 biolink:BiologicalProcess negative regulation of serotonin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. go.json down regulation of serotonin secretion|down-regulation of serotonin secretion|downregulation of serotonin secretion|inhibition of serotonin secretion|positive regulation of serotonin release http://purl.obolibrary.org/obo/GO_0014063 GO:0038030 biolink:BiologicalProcess obsolete non-canonical Wnt signaling pathway via MAPK cascade OBSOLETE. The series of molecular signals initiated by a Wnt protein binding to a frizzled family receptor on the surface of a target cell, where the signal is passed on via the MAPKKK cascade. go.json non-canonical Wnt receptor signaling pathway via MAPK cascade|non-canonical Wnt receptor signaling pathway via MAPK signaling|non-canonical Wnt receptor signaling pathway via MAPKKK cascade|non-canonical Wnt receptor signalling pathway via MAPKKK cascade|non-canonical Wnt-activated signaling pathway via MAPK cascade True http://purl.obolibrary.org/obo/GO_0038030 GO:0014062 biolink:BiologicalProcess regulation of serotonin secretion Any process that modulates the frequency, rate or extent of the regulated release of serotonin. go.json regulation of serotonin release http://purl.obolibrary.org/obo/GO_0014062 GO:0038032 biolink:BiologicalProcess termination of G protein-coupled receptor signaling pathway The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal. go.json termination of G-protein coupled receptor signaling pathway|termination of G-protein coupled receptor signalling pathway|termination of GPCR signaling pathway http://purl.obolibrary.org/obo/GO_0038032 GO:0014061 biolink:BiologicalProcess regulation of norepinephrine secretion Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. go.json regulation of noradrenaline secretion http://purl.obolibrary.org/obo/GO_0014061 GO:0014060 biolink:BiologicalProcess regulation of epinephrine secretion Any process that modulates the frequency, rate or extent of the regulated release of epinephrine. go.json regulation of adrenaline secretion http://purl.obolibrary.org/obo/GO_0014060 GO:0038031 biolink:BiologicalProcess non-canonical Wnt signaling pathway via JNK cascade The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade. go.json non-canonical Wnt receptor signaling pathway via JNK cascade|non-canonical Wnt receptor signalling pathway via JNK cascade|non-canonical Wnt-activated signaling pathway via JNK cascade http://purl.obolibrary.org/obo/GO_0038031 GO:0014067 biolink:BiologicalProcess obsolete negative regulation of phosphatidylinositol 3-kinase signaling OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. go.json down regulation of phosphatidylinositol 3-kinase cascade|down-regulation of phosphatidylinositol 3-kinase cascade|downregulation of phosphatidylinositol 3-kinase cascade|inhibition of phosphatidylinositol 3-kinase cascade|negative regulation of PI 3-kinase cascade|negative regulation of PI3K cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of phosphoinositide 3-kinase cascade True http://purl.obolibrary.org/obo/GO_0014067 GO:0038034 biolink:BiologicalProcess signal transduction in absence of ligand The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. go.json addiction receptor signaling pathway|basal signaling|dependence receptor signaling pathway|negative signal transduction|non-classical signal transduction|signal transduction in absence of agonist http://purl.obolibrary.org/obo/GO_0038034 GO:0038033 biolink:BiologicalProcess positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis. go.json VEGF-VEGFR-induced endothelial cell chemotaxis|VEGF-mediated chemotactic endothelial cell migration|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway|positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway|vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis http://purl.obolibrary.org/obo/GO_0038033 GO:0014066 biolink:BiologicalProcess obsolete regulation of phosphatidylinositol 3-kinase signaling OBSOLETE. Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. go.json regulation of PI 3-kinase cascade|regulation of PI3K cascade|regulation of phosphatidylinositol 3-kinase cascade|regulation of phosphoinositide 3-kinase cascade True http://purl.obolibrary.org/obo/GO_0014066 GO:0038036 biolink:MolecularActivity sphingosine-1-phosphate receptor activity Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. go.json S1P receptor activity http://purl.obolibrary.org/obo/GO_0038036 GO:0014065 biolink:BiologicalProcess obsolete phosphatidylinositol 3-kinase signaling OBSOLETE. A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. go.json PI 3-kinase cascade|PI3K cascade|PI3K signal transduction|PI3K signaling|phosphatidylinositol 3-kinase cascade|phosphatidylinositol 3-kinase signal transduction|phosphoinositide 3-kinase cascade True http://purl.obolibrary.org/obo/GO_0014065 GO:0014064 biolink:BiologicalProcess positive regulation of serotonin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. go.json activation of serotonin secretion|positive regulation of serotonin release|stimulation of serotonin secretion|up regulation of serotonin secretion|up-regulation of serotonin secretion|upregulation of serotonin secretion http://purl.obolibrary.org/obo/GO_0014064 GO:0038035 biolink:BiologicalProcess G protein-coupled receptor signaling in absence of ligand The series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist. go.json G-protein coupled receptor signaling in absence of agonist|G-protein coupled receptor signaling in absence of ligand|G-protein coupled receptor signalling in absence of ligand|basal G-protein coupled receptor signaling http://purl.obolibrary.org/obo/GO_0038035 GO:0102980 biolink:MolecularActivity 2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP = (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. MetaCyc:RXN-9565 go.json http://purl.obolibrary.org/obo/GO_0102980 GO:0102982 biolink:MolecularActivity UDP-3-dehydro-alpha-D-glucose dehydrogenase activity Catalysis of the reaction: UDP-alpha-D-glucose + NAD = H+ + UDP-3-keto-alpha-D-glucose + NADH. MetaCyc:RXN-9578|RHEA:35755 go.json http://purl.obolibrary.org/obo/GO_0102982 GO:0102981 biolink:MolecularActivity 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP = (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+. MetaCyc:RXN-9567 go.json http://purl.obolibrary.org/obo/GO_0102981 GO:0102984 biolink:MolecularActivity sulfoacetaldehyde dehydrogenase activity Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD = sulfonatoacetate + NADH + 2 H+. EC:1.2.1.73|MetaCyc:RXN-9592|RHEA:25637 go.json http://purl.obolibrary.org/obo/GO_0102984 GO:0102983 biolink:MolecularActivity xylogalacturonan beta-1,3-xylosyltransferase activity Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan = UDP + 4 H+ + a xylogalacturonan. EC:2.4.2.41|MetaCyc:RXN-9589 go.json http://purl.obolibrary.org/obo/GO_0102983 GO:0102986 biolink:MolecularActivity trehalose synthase activity Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose = alpha,alpha-trehalose + H+ + a nucleoside diphosphate. EC:2.4.1.245|MetaCyc:RXN-9603|RHEA:47416 go.json http://purl.obolibrary.org/obo/GO_0102986 GO:0102985 biolink:MolecularActivity delta12-fatty-acid desaturase activity Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor = linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. EC:1.14.19.6|MetaCyc:RXN-9601|RHEA:25856 go.json http://purl.obolibrary.org/obo/GO_0102985 GO:0102988 biolink:MolecularActivity 9,12-cis-hexadecadienoic acid delta 15 desaturase activity Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor = 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-9617|RHEA:46232 go.json http://purl.obolibrary.org/obo/GO_0102988 GO:0102987 biolink:MolecularActivity palmitoleic acid delta 12 desaturase activity Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor = (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-9616|RHEA:45096 go.json http://purl.obolibrary.org/obo/GO_0102987 GO:0038027 biolink:BiologicalProcess apolipoprotein A-I-mediated signaling pathway The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json apolipoprotein A-I-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038027 GO:0038026 biolink:BiologicalProcess reelin-mediated signaling pathway The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json reeler-mediated signaling pathway|reelin-mediated signal transduction pathway|reelin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038026 GO:0102989 biolink:MolecularActivity 5-pentadecatrienylresorcinol synthase activity Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) = 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide. MetaCyc:RXN-9618 go.json http://purl.obolibrary.org/obo/GO_0102989 GO:0038029 biolink:BiologicalProcess obsolete epidermal growth factor receptor signaling pathway via MAPK cascade OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal is transmitted via the MAPKKK cascade. go.json EGFR signaling pathway via MAPKKK cascade|EGFR signaling via MAPKKK cascade|EGFR/MAPK signaling|epidermal growth factor receptor signaling pathway via MAPKKK cascade|epidermal growth factor receptor signalling pathway via MAPKKK cascade True http://purl.obolibrary.org/obo/GO_0038029 GO:0038028 biolink:BiologicalProcess obsolete insulin receptor signaling pathway via phosphatidylinositol 3-kinase OBSOLETE. An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade. go.json insulin receptor signaling pathway via PI3K cascade|insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade|insulin receptor signaling via PI3K|insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade True http://purl.obolibrary.org/obo/GO_0038028 GO:0014074 biolink:BiologicalProcess response to purine-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. go.json response to purine http://purl.obolibrary.org/obo/GO_0014074 GO:0014073 biolink:BiologicalProcess response to tropane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine. go.json http://purl.obolibrary.org/obo/GO_0014073 GO:0038021 biolink:MolecularActivity leptin receptor activity Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0038021 GO:0014072 biolink:BiologicalProcess response to isoquinoline alkaloid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. go.json http://purl.obolibrary.org/obo/GO_0014072 GO:0038020 biolink:BiologicalProcess insulin receptor recycling The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. go.json http://purl.obolibrary.org/obo/GO_0038020 GO:0014071 biolink:BiologicalProcess response to cycloalkane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n. go.json http://purl.obolibrary.org/obo/GO_0014071 GO:0038023 biolink:MolecularActivity signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. go.json receptor activity|receptor activity involved in signal transduction|signalling receptor activity http://purl.obolibrary.org/obo/GO_0038023 goslim_agr|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_metagenomics|goslim_mouse|goslim_pir|goslim_plant GO:0038022 biolink:MolecularActivity G protein-coupled olfactory receptor activity Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G-protein coupled odorant receptor activity|G-protein coupled olfactory receptor activity|odorant receptor activity, G-protein coupled|olfactory receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0038022 GO:0014076 biolink:BiologicalProcess response to fluoxetine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor. go.json response to SSRI|response to selective serotonin reuptake inhibitor http://purl.obolibrary.org/obo/GO_0014076 gocheck_do_not_manually_annotate GO:0038025 biolink:MolecularActivity reelin receptor activity Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json reeler receptor activity http://purl.obolibrary.org/obo/GO_0038025 GO:0014075 biolink:BiologicalProcess response to amine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. go.json response to amine stimulus http://purl.obolibrary.org/obo/GO_0014075 GO:0038024 biolink:MolecularActivity cargo receptor activity Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. Reactome:R-HSA-3000103|Reactome:R-HSA-3000112|Reactome:R-HSA-3000122|Reactome:R-HSA-3000137|Reactome:R-HSA-350168|Reactome:R-HSA-9759202|Reactome:R-HSA-9759209 go.json endocytic receptor activity|receptor activity|receptor activity involved in receptor-mediated endocytosis|transport receptor activity http://purl.obolibrary.org/obo/GO_0038024 goslim_drosophila|goslim_generic GO:0004646 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004646 GO:0004645 biolink:MolecularActivity 1,4-alpha-oligoglucan phosphorylase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. EC:2.4.1.1|MetaCyc:RXN-1826 go.json 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity|1,4-alpha-glucan phosphorylase activity|alpha-glucan phosphorylase|amylopectin phosphorylase|amylophosphorylase activity|glucan phosphorylase|glucosan phosphorylase|granulose phosphorylase|muscle phosphorylase|muscle phosphorylase a and b activity|myophosphorylase|polyphosphorylase activity|potato phosphorylase|starch phosphorylase http://purl.obolibrary.org/obo/GO_0004645 GO:0004648 biolink:MolecularActivity O-phospho-L-serine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. EC:2.6.1.52|MetaCyc:PSERTRANSAM-RXN|RHEA:14329|Reactome:R-HSA-977333 go.json 3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity|3-phosphoserine aminotransferase activity|3PHP transaminase activity|L-phosphoserine aminotransferase activity|PSAT activity|PdxC|SerC|hydroxypyruvic phosphate--glutamic transaminase activity|phosphohydroxypyruvate transaminase activity|phosphohydroxypyruvic--glutamic transaminase activity|phosphoserine aminotransferase activity|phosphoserine transaminase activity http://purl.obolibrary.org/obo/GO_0004648 GO:0004647 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004647 GO:0004642 biolink:MolecularActivity phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. EC:6.3.5.3|KEGG_REACTION:R04463|MetaCyc:FGAMSYN-RXN|RHEA:17129|Reactome:R-HSA-73812 go.json 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)|5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)|FGAM synthase activity|FGAM synthetase activity|FGAR amidotransferase activity|FGARAT activity|N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)|formylglycinamide ribonucloetide amidotransferase activity|formylglycinamide ribotide amidotransferase activity|phosphoribosylformylglycinamidine synthetase activity|phosphoribosylformylglycineamidine synthetase activity http://purl.obolibrary.org/obo/GO_0004642 GO:0004641 biolink:MolecularActivity phosphoribosylformylglycinamidine cyclo-ligase activity Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. EC:6.3.3.1|KEGG_REACTION:R04208|MetaCyc:AIRS-RXN|RHEA:23032|Reactome:R-HSA-73810 go.json 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)|2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)|5'-aminoimidazole ribonucleotide synthetase activity|AIR synthase activity|AIR synthetase activity|AIRS activity|phosphoribosyl-aminoimidazole synthetase activity|phosphoribosylaminoimidazole synthetase activity http://purl.obolibrary.org/obo/GO_0004641 GO:0004644 biolink:MolecularActivity phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. EC:2.1.2.2|MetaCyc:GART-RXN|RHEA:15053|Reactome:R-HSA-73813 go.json 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity|2-amino-N-ribosylacetamide 5'-phosphate transformylase activity|5'-phosphoribosylglycinamide transformylase activity|5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity|GAR TFase activity|GAR formyltransferase activity|GAR transformylase activity|GART activity|glycinamide ribonucleotide transformylase activity http://purl.obolibrary.org/obo/GO_0004644 GO:0004643 biolink:MolecularActivity phosphoribosylaminoimidazolecarboxamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. EC:2.1.2.3|MetaCyc:AICARTRANSFORM-RXN|RHEA:22192|Reactome:R-HSA-73798 go.json 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity|10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity|5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity|5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity|5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity|5-amino-4-imidazolecarboxamide ribotide transformylase activity|AICAR formyltransferase activity|AICAR transformylase activity|aminoimidazolecarboxamide ribonucleotide transformylase activity http://purl.obolibrary.org/obo/GO_0004643 GO:0004640 biolink:MolecularActivity phosphoribosylanthranilate isomerase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. EC:5.3.1.24|KEGG_REACTION:R03509|MetaCyc:PRAISOM-RXN|RHEA:21540 go.json IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)|N-(5'-phosphoribosyl)anthranilate isomerase activity|N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity|N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity|PRA isomerase activity|PRAI activity http://purl.obolibrary.org/obo/GO_0004640 GO:0004649 biolink:MolecularActivity poly(ADP-ribose) glycohydrolase activity Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. EC:3.2.1.143|MetaCyc:3.2.1.143-RXN|RHEA:52216|Reactome:R-HSA-5651828|Reactome:R-HSA-8952903 go.json http://purl.obolibrary.org/obo/GO_0004649 GO:0004657 biolink:MolecularActivity proline dehydrogenase activity Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. EC:1.5.5.2|MetaCyc:RXN-14903|RHEA:23784|Reactome:R-HSA-6784224|Reactome:R-HSA-70670|Reactome:R-HSA-8955817 go.json L-proline dehydrogenase activity|proline oxidase activity http://purl.obolibrary.org/obo/GO_0004657 GO:0004656 biolink:MolecularActivity procollagen-proline 4-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. EC:1.14.11.2|KEGG_REACTION:R03219|MetaCyc:1.14.11.2-RXN|RHEA:18945|Reactome:R-HSA-1650808 go.json collagen proline hydroxylase activity|hydroxylase, collagen proline activity|peptidyl proline hydroxylase activity|procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity|procollagen-proline,2-oxoglutarate-4-dioxygenase activity|proline hydroxylase activity|proline protocollagen hydroxylase activity|proline, 2-oxoglutarate dioxygenase activity|proline,2-oxoglutarate 4-dioxygenase activity|prolyl 4-hydroxylase activity|prolyl hydroxylase activity|prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity|prolylprotocollagen dioxygenase activity|prolylprotocollagen hydroxylase activity|protocollagen hydroxylase activity|protocollagen proline 4-hydroxylase activity|protocollagen proline dioxygenase activity|protocollagen proline hydroxylase activity|protocollagen prolyl hydroxylase activity http://purl.obolibrary.org/obo/GO_0004656 GO:0004659 biolink:MolecularActivity prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). Reactome:R-HSA-6806674 go.json http://purl.obolibrary.org/obo/GO_0004659 GO:0004658 biolink:MolecularActivity propionyl-CoA carboxylase activity Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. EC:6.4.1.3|MetaCyc:PROPIONYL-COA-CARBOXY-RXN|RHEA:23720|Reactome:R-HSA-71031 go.json PCCase activity|propanoyl-CoA:carbon-dioxide ligase (ADP-forming)|propionyl coenzyme A carboxylase activity http://purl.obolibrary.org/obo/GO_0004658 GO:0004653 biolink:MolecularActivity polypeptide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. EC:2.4.1.41|MetaCyc:2.4.1.41-RXN|Reactome:R-HSA-5096532|Reactome:R-HSA-5096537|Reactome:R-HSA-8851619|Reactome:R-HSA-913675|Reactome:R-HSA-9683760|Reactome:R-HSA-9694438 go.json UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity|UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity|UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity|glycoprotein acetylgalactosaminyltransferase activity|polypeptide-N-acetylgalactosamine transferase activity|protein-UDP acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0004653 GO:0004652 biolink:MolecularActivity obsolete polynucleotide adenylyltransferase activity OBSOLETE. Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. go.json AMP polynucleotidylexotransferase activity|ATP-polynucleotide adenylyltransferase activity|ATP:polynucleotide adenylyltransferase activity|ATP:polynucleotidylexotransferase activity|NTP polymerase activity|RNA adenylating enzyme activity|RNA formation factors, PF1|adenosine triphosphate:ribonucleic acid adenylyltransferase activity|poly(A) hydrolase activity|poly(A) polymerase activity|poly(A) synthetase activity|poly-A polymerase activity|polyadenylate nucleotidyltransferase activity|polyadenylate polymerase activity|polyadenylate synthetase activity|polyadenylic acid polymerase activity|polyadenylic polymerase activity|terminal riboadenylate transferase activity True http://purl.obolibrary.org/obo/GO_0004652 GO:0004655 biolink:MolecularActivity porphobilinogen synthase activity Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen. EC:4.2.1.24|KEGG_REACTION:R00036|MetaCyc:PORPHOBILSYNTH-RXN|RHEA:24064|Reactome:R-HSA-189439 go.json 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)|5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)|5-levulinic acid dehydratase activity|aminolevulinate dehydratase activity|aminolevulinic dehydratase activity|delta-aminolevulinate dehydratase activity|delta-aminolevulinic acid dehydrase activity|delta-aminolevulinic acid dehydratase activity|delta-aminolevulinic dehydratase activity http://purl.obolibrary.org/obo/GO_0004655 GO:0004654 biolink:MolecularActivity polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. EC:2.7.7.8|MetaCyc:2.7.7.8-RXN|RHEA:22096 go.json nucleoside diphosphate:polynucleotidyl transferase activity|polynucleotide phosphorylase activity|polyribonucleotide phosphorylase activity|polyribonucleotide:phosphate nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0004654 GO:0004651 biolink:MolecularActivity polynucleotide 5'-phosphatase activity Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. EC:3.1.3.33|MetaCyc:RXN-21861|RHEA:11008|Reactome:R-HSA-77078 go.json 5'-polynucleotidase activity|polynucleotide 5'-phosphohydrolase activity|polynucleotide 5'-triphosphatase activity http://purl.obolibrary.org/obo/GO_0004651 GO:0004650 biolink:MolecularActivity polygalacturonase activity Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans. EC:3.2.1.15|MetaCyc:RXN-2103 go.json endo-D-galacturonase activity|endo-polygalacturonase activity|endogalacturonase activity|endopolygalacturonase activity|pectin depolymerase activity|pectin hydrolase activity|pectin polygalacturonase activity|pectinase activity|pectolase activity|poly(1,4-alpha-D-galacturonide) glycanohydrolase activity|poly-alpha-1,4-galacturonide glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0004650 GO:0004624 biolink:MolecularActivity obsolete secreted phospholipase A2 activity OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. go.json secreted phospholipase A2 activity True http://purl.obolibrary.org/obo/GO_0004624 GO:0004623 biolink:MolecularActivity phospholipase A2 activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. EC:3.1.1.4|MetaCyc:PHOSPHOLIPASE-A2-RXN|MetaCyc:RXN-15067|RHEA:15801|Reactome:R-HSA-1482604|Reactome:R-HSA-1482656|Reactome:R-HSA-1482679|Reactome:R-HSA-1482745|Reactome:R-HSA-1482759|Reactome:R-HSA-1482771|Reactome:R-HSA-1482776|Reactome:R-HSA-1482778|Reactome:R-HSA-1482816|Reactome:R-HSA-1482825|Reactome:R-HSA-1482856|Reactome:R-HSA-1482868|Reactome:R-HSA-1482884|Reactome:R-HSA-1482887|Reactome:R-HSA-1482897|Reactome:R-HSA-1482900|Reactome:R-HSA-1482907|Reactome:R-HSA-1602368|Reactome:R-HSA-1602374|Reactome:R-HSA-1602377|Reactome:R-HSA-1602398|Reactome:R-HSA-1602399|Reactome:R-HSA-1602417|Reactome:R-HSA-1602446|Reactome:R-HSA-8848484 go.json cytosolic phospholipase A2 activity|lecithinase A activity|phosphatidase activity|phosphatidolipase activity|phosphatidylcholine 2-acylhydrolase activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|secreted phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0004623 goslim_chembl GO:0004626 biolink:MolecularActivity obsolete cytosolic phospholipase A2 activity OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. go.json cytosolic phospholipase A2 activity True http://purl.obolibrary.org/obo/GO_0004626 GO:0004625 biolink:MolecularActivity obsolete calcium-dependent secreted phospholipase A2 activity OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. go.json calcium-dependent secreted phospholipase A2 activity True http://purl.obolibrary.org/obo/GO_0004625 GO:0004620 biolink:MolecularActivity phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid. Reactome:R-HSA-6786650|Reactome:R-HSA-6792445 go.json http://purl.obolibrary.org/obo/GO_0004620 goslim_chembl GO:0004622 biolink:MolecularActivity lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. EC:3.1.1.5|MetaCyc:LYSOPHOSPHOLIPASE-RXN|RHEA:15177|Reactome:R-HSA-1482545|Reactome:R-HSA-1482571|Reactome:R-HSA-1482612|Reactome:R-HSA-1482629|Reactome:R-HSA-1482685|Reactome:R-HSA-1482696|Reactome:R-HSA-6814254|Reactome:R-HSA-6814766|Reactome:R-HSA-6814778|Reactome:R-HSA-8847912 go.json 2-lysophosphatidylcholine acylhydrolase activity|lecithinase B activity|lecitholipase activity|lysolecithinase activity|lysophopholipase L2|lysophosphatidase activity|lysophosphatidylcholine hydrolase activity|lysophospholipase A1|phosphatidase B|phospholipase B activity http://purl.obolibrary.org/obo/GO_0004622 goslim_chembl GO:0004621 biolink:MolecularActivity glycosylphosphatidylinositol phospholipase D activity Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. EC:3.1.4.50|MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN|RHEA:10832|Reactome:R-HSA-8940388 go.json GPI-PLD activity|glycoprotein phospholipase D activity|glycoprotein-phosphatidylinositol phosphatidohydrolase activity|phosphatidylinositol phospholipase D activity|phosphatidylinositol-glycan-specific phospholipase D activity|phosphatidylinositol-specific phospholipase D activity http://purl.obolibrary.org/obo/GO_0004621 GO:0004628 biolink:MolecularActivity obsolete calcium-independent cytosolic phospholipase A2 activity OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. go.json calcium-independent cytosolic phospholipase A2 activity True http://purl.obolibrary.org/obo/GO_0004628 GO:0004627 biolink:MolecularActivity obsolete calcium-dependent cytosolic phospholipase A2 activity OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. go.json calcium-dependent cytosolic phospholipase A2 activity True http://purl.obolibrary.org/obo/GO_0004627 GO:0004629 biolink:MolecularActivity phospholipase C activity Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. Reactome:R-HSA-1112666|Reactome:R-HSA-114688|Reactome:R-HSA-114689|Reactome:R-HSA-398193|Reactome:R-HSA-399998|Reactome:R-HSA-5362553 go.json phosphatidase C http://purl.obolibrary.org/obo/GO_0004629 GO:0004635 biolink:MolecularActivity phosphoribosyl-AMP cyclohydrolase activity Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. EC:3.5.4.19|KEGG_REACTION:R04037|MetaCyc:HISTCYCLOHYD-RXN|RHEA:20049 go.json 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity|PRAMP-cyclohydrolase activity|phosphoribosyladenosine monophosphate cyclohydrolase activity http://purl.obolibrary.org/obo/GO_0004635 GO:0004634 biolink:MolecularActivity phosphopyruvate hydratase activity Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. EC:4.2.1.11|MetaCyc:2PGADEHYDRAT-RXN|RHEA:10164|Reactome:R-HSA-70494|Reactome:R-HSA-71660 go.json 14-3-2-protein|2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)|2-phospho-D-glycerate hydro-lyase activity|2-phospho-D-glycerate-hydrolase activity|2-phosphoglycerate dehydratase activity|2-phosphoglycerate enolase activity|2-phosphoglyceric dehydratase activity|enolase activity|gamma-enolase activity|nervous-system specific enolase|phosphoenolpyruvate hydratase activity http://purl.obolibrary.org/obo/GO_0004634 GO:0004637 biolink:MolecularActivity phosphoribosylamine-glycine ligase activity Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate. EC:6.3.4.13|KEGG_REACTION:R04144|MetaCyc:GLYRIBONUCSYN-RXN|RHEA:17453|Reactome:R-HSA-73814 go.json 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity|5'-phosphoribosylglycinamide synthetase activity|5-phospho-D-ribosylamine:glycine ligase (ADP-forming)|GAR|GAR synthetase activity|GARS activity|glycinamide ribonucleotide synthetase activity|glycineamide ribonucleotide synthetase activity|phosphoribosylglycinamide synthetase activity|phosphoribosylglycineamide synthetase activity http://purl.obolibrary.org/obo/GO_0004637 GO:0004636 biolink:MolecularActivity phosphoribosyl-ATP diphosphatase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+. EC:3.6.1.31|KEGG_REACTION:R04035|MetaCyc:HISTPRATPHYD-RXN|RHEA:22828 go.json 1-(5-phosphoribosyl)-ATP diphosphohydrolase activity|phosphoribosyl-ATP pyrophosphatase activity|phosphoribosyladenosine triphosphate pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0004636 GO:0004631 biolink:MolecularActivity phosphomevalonate kinase activity Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+. EC:2.7.4.2|KEGG_REACTION:R03245|MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN|RHEA:16341|Reactome:R-HSA-191422 go.json 5-phosphomevalonate kinase activity|ATP:(R)-5-phosphomevalonate phosphotransferase activity|ATP:5-phosphomevalonate phosphotransferase activity|mevalonate phosphate kinase activity|mevalonate-5-phosphate kinase activity|mevalonic acid phosphate kinase activity http://purl.obolibrary.org/obo/GO_0004631 GO:0004630 biolink:MolecularActivity phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. EC:3.1.4.4|MetaCyc:PHOSCHOL-RXN|RHEA:14445|Reactome:R-HSA-1483142|Reactome:R-HSA-1483182|Reactome:R-HSA-2029471 go.json choline phosphatase activity|lecithinase D activity|lipophosphodiesterase II activity|phosphatidylcholine phosphatidohydrolase activity http://purl.obolibrary.org/obo/GO_0004630 goslim_chembl GO:0004633 biolink:MolecularActivity phosphopantothenoylcysteine decarboxylase activity Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate. EC:4.1.1.36|KEGG_REACTION:R03269|MetaCyc:P-PANTOCYSDECARB-RXN|RHEA:16793|Reactome:R-HSA-196840 go.json 4-phosphopantothenoyl-L-cysteine decarboxylase activity|4-phosphopantotheoylcysteine decarboxylase activity|N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity|N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)|N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity|PPC-decarboxylase activity http://purl.obolibrary.org/obo/GO_0004633 GO:0004632 biolink:MolecularActivity phosphopantothenate--cysteine ligase activity Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. EC:6.3.2.5|MetaCyc:P-PANTOCYSLIG-RXN|RHEA:19397|Reactome:R-HSA-196753 go.json (R)-4'-phosphopantothenate:L-cysteine ligase activity|phosphopantothenate-cysteine ligase activity|phosphopantothenoylcysteine synthetase activity http://purl.obolibrary.org/obo/GO_0004632 GO:0004639 biolink:MolecularActivity phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate. EC:6.3.2.6|KEGG_REACTION:R04591|MetaCyc:SAICARSYN-RXN|RHEA:22628|Reactome:R-HSA-73805 go.json 4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity|4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity|4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity|5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)|5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity|PurC|SAICAR synthase activity|SAICAR synthetase activity|SAICARs activity|phosphoribosylaminoimidazole-succinocarboxamide synthase activity|phosphoribosylaminoimidazole-succinocarboxamide synthetase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity http://purl.obolibrary.org/obo/GO_0004639 GO:0004638 biolink:MolecularActivity phosphoribosylaminoimidazole carboxylase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. EC:4.1.1.21|KEGG_REACTION:R04209|MetaCyc:AIRCARBOXY-RXN|RHEA:10792|Reactome:R-HSA-73806 go.json 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity|5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]|5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity|5-amino-1-ribosylimidazole 5-phosphate carboxylase activity|5-phosphoribosyl-5-aminoimidazole carboxylase activity|ADE2|AIR carboxylase activity|class II PurE http://purl.obolibrary.org/obo/GO_0004638 GO:0004602 biolink:MolecularActivity glutathione peroxidase activity Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. EC:1.11.1.9|MetaCyc:GLUTATHIONE-PEROXIDASE-RXN|RHEA:16833|Reactome:R-HSA-2161791|Reactome:R-HSA-2161946|Reactome:R-HSA-2161959|Reactome:R-HSA-2161999|Reactome:R-HSA-3323013|Reactome:R-HSA-3341277|Reactome:R-HSA-3341397|Reactome:R-HSA-3343700|Reactome:R-HSA-6799695|Reactome:R-HSA-71676 go.json GSH peroxidase activity|glutathione:hydrogen-peroxide oxidoreductase activity|non-selenium glutathione peroxidase activity|reduced glutathione peroxidase activity|selenium-glutathione peroxidase activity http://purl.obolibrary.org/obo/GO_0004602 GO:0004601 biolink:MolecularActivity peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O. EC:1.11.1.-|KEGG_REACTION:R03532|Reactome:R-HSA-1222346|Reactome:R-HSA-140359|Reactome:R-HSA-209815|Reactome:R-HSA-209840|Reactome:R-HSA-209925|Reactome:R-HSA-209973|Reactome:R-HSA-2309773|Reactome:R-HSA-2559639|Reactome:R-HSA-3341296|Reactome:R-HSA-350901|Reactome:R-HSA-5631885|Reactome:R-HSA-6789031|Reactome:R-HSA-6789126|Reactome:R-HSA-8855490|Reactome:R-HSA-8933635|Wikipedia:Peroxidase go.json MPO|bacterial catalase-peroxidase activity|donor:hydrogen-peroxide oxidoreductase activity|eosinophil peroxidase activity|extensin peroxidase|guaiacol peroxidase|heme peroxidase|horseradish peroxidase (HRP)|japanese radish peroxidase|lactoperoxidase activity|myeloperoxidase activity|oxyperoxidase activity|peroxidase reaction|protoheme peroxidase|pyrocatechol peroxidase|scopoletin peroxidase|secretory plant peroxidase activity|thiocyanate peroxidase|verdoperoxidase http://purl.obolibrary.org/obo/GO_0004601 goslim_metagenomics GO:0004604 biolink:MolecularActivity phosphoadenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. EC:1.8.4.8|KEGG_REACTION:R02021|MetaCyc:1.8.4.8-RXN|RHEA:11724 go.json 3'-phosphoadenylylsulfate reductase activity|PAPS reductase activity|PAPS reductase, thioredoxin-dependent activity|PAPS sulfotransferase activity|PAdoPS reductase activity|adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)|adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)|phosphoadenosine-phosphosulfate reductase activity|phosphoadenylyl-sulphate reductase (thioredoxin) activity|thioredoxin:3'-phospho-adenylylsulfate reductase activity|thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity http://purl.obolibrary.org/obo/GO_0004604 GO:0004603 biolink:MolecularActivity phenylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. EC:2.1.1.28|MetaCyc:2.1.1.28-RXN|RHEA:12176|Reactome:R-HSA-209903 go.json S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity|noradrenalin N-methyltransferase activity|noradrenaline N-methyltransferase activity|norepinephrine N-methyltransferase activity|norepinephrine methyltransferase activity|phenethanolamine N-methyltransferase activity|phenethanolamine methyltransferase activity http://purl.obolibrary.org/obo/GO_0004603 GO:0004600 biolink:MolecularActivity obsolete cyclophilin OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity. go.json cyclophilin True http://purl.obolibrary.org/obo/GO_0004600 GO:0004609 biolink:MolecularActivity phosphatidylserine decarboxylase activity Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine. EC:4.1.1.65|KEGG_REACTION:R02055|MetaCyc:PHOSPHASERDECARB-RXN|RHEA:20828|Reactome:R-HSA-1483212 go.json PS decarboxylase activity|phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)|phosphatidyl-L-serine carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0004609 GO:0004606 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004606 GO:0004605 biolink:MolecularActivity phosphatidate cytidylyltransferase activity Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. EC:2.7.7.41|MetaCyc:CDPDIGLYSYN-RXN|RHEA:16229|Reactome:R-HSA-1483121|Reactome:R-HSA-1483165 go.json CDP diglyceride pyrophosphorylase activity|CDP-DG|CDP-diacylglyceride synthetase activity|CDP-diacylglycerol synthase activity|CDP-diglyceride diphosphorylase activity|CDP-diglyceride pyrophosphorylase activity|CDP-diglyceride synthase activity|CDP-diglyceride synthetase activity|CTP-diacylglycerol synthetase activity|CTP:1,2-diacylglycerophosphate-cytidyl transferase activity|CTP:phosphatidate cytidylyltransferase activity|DAG synthetase activity|cytidine diphosphoglyceride pyrophosphorylase activity|phosphatidate cytidyltransferase activity|phosphatidic acid cytidylyltransferase activity http://purl.obolibrary.org/obo/GO_0004605 GO:0004608 biolink:MolecularActivity phosphatidylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine. EC:2.1.1.17|KEGG_REACTION:R02056|MetaCyc:2.1.1.17-RXN|RHEA:11164|Reactome:R-HSA-1483174 go.json LMTase activity|PEMT|S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity|lipid methyl transferase activity|phosphatidylethanolamine methyltransferase activity|phosphatidylethanolamine-N-methylase activity|phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity http://purl.obolibrary.org/obo/GO_0004608 GO:0004607 biolink:MolecularActivity phosphatidylcholine-sterol O-acyltransferase activity Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. EC:2.3.1.43|MetaCyc:2.3.1.43-RXN|RHEA:21204|Reactome:R-HSA-264695 go.json LCAT (lecithin-cholesterol acyltransferase)|LCAT activity|lecithin--cholesterol acyltransferase activity|lecithin:cholesterol acyltransferase activity|phosphatidylcholine:sterol O-acyltransferase activity|phospholipid--cholesterol acyltransferase activity http://purl.obolibrary.org/obo/GO_0004607 GO:0004613 biolink:MolecularActivity phosphoenolpyruvate carboxykinase (GTP) activity Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. EC:4.1.1.32|MetaCyc:4.1.1.32-RXN|RHEA:10388|Reactome:R-HSA-372819|Reactome:R-HSA-70241 go.json GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)|GTP:oxaloacetate carboxy-lyase (transphosphorylating)|phosphoenolpyruvate carboxylase (GTP)|phosphoenolpyruvic carboxykinase|phosphoenolpyruvic carboxykinase (GTP)|phosphoenolpyruvic carboxylase (GTP)|phosphopyruvate (guanosine triphosphate) carboxykinase activity|phosphopyruvate carboxylase (GTP) http://purl.obolibrary.org/obo/GO_0004613 GO:0004612 biolink:MolecularActivity phosphoenolpyruvate carboxykinase (ATP) activity Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate. EC:4.1.1.49|KEGG_REACTION:R00341|MetaCyc:PEPCARBOXYKIN-RXN|RHEA:18617 go.json ATP:oxaloacetate carboxy-lyase (transphosphorylating)|ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)|PEPCK (ATP)|PEPK|phosphoenolpyruvate carboxylase (ATP)|phosphoenolpyruvic carboxykinase|phosphopyruvate carboxykinase|phosphopyruvate carboxykinase (adenosine triphosphate)|phosphopyruvate carboxylase (ATP) http://purl.obolibrary.org/obo/GO_0004612 GO:0004615 biolink:MolecularActivity phosphomannomutase activity Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. EC:5.4.2.8|KEGG_REACTION:R01818|MetaCyc:PHOSMANMUT-RXN|RHEA:11140|Reactome:R-HSA-3781926|Reactome:R-HSA-446201 go.json D-mannose 1,6-phosphomutase activity|alpha-D-mannose 1,6-phosphomutase activity|mannose phosphomutase activity|phosphomannose mutase activity http://purl.obolibrary.org/obo/GO_0004615 GO:0004614 biolink:MolecularActivity phosphoglucomutase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. EC:5.4.2.2|MetaCyc:PHOSPHOGLUCMUT-RXN|RHEA:23536|Reactome:R-HSA-5609939|Reactome:R-HSA-9638125|Reactome:R-HSA-9638127 go.json alpha-D-glucose 1,6-phosphomutase activity|glucose phosphomutase activity|phosphoglucose mutase activity http://purl.obolibrary.org/obo/GO_0004614 GO:0004611 biolink:MolecularActivity phosphoenolpyruvate carboxykinase activity Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. EC:4.1.1.32 go.json PEP carboxykinase activity|PEPCK activity|phosphopyruvate carboxylase activity http://purl.obolibrary.org/obo/GO_0004611 GO:0004610 biolink:MolecularActivity phosphoacetylglucosamine mutase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. EC:5.4.2.3|KEGG_REACTION:R08193|MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN|RHEA:23804|Reactome:R-HSA-446185 go.json N-acetyl-D-glucosamine 1,6-phosphomutase activity|N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity|N-acetylglucosamine-phosphate mutase activity|acetylaminodeoxyglucose phosphomutase activity|acetylglucosamine phosphomutase activity|phospho-N-acetylglucosamine mutase activity http://purl.obolibrary.org/obo/GO_0004610 GO:0004617 biolink:MolecularActivity phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. EC:1.1.1.95|MetaCyc:PGLYCDEHYDROG-RXN|RHEA:12641|Reactome:R-HSA-977348 go.json 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity|3-phosphoglycerate dehydrogenase activity|3-phosphoglycerate:NAD+ 2-oxidoreductase activity|3-phosphoglyceric acid dehydrogenase activity|3PHP reductase activity|D- and L-HGA|D-3-phosphoglycerate dehydrogenase activity|D-3-phosphoglycerate:NAD+ oxidoreductase activity|PGDH activity|SerA|SerA 3PG dehydrogenase activity|alpha-KG reductase activity|alpha-phosphoglycerate dehydrogenase activity|alphaKG reductase activity|glycerate 3-phosphate dehydrogenase activity|glycerate-1,3-phosphate dehydrogenase activity|phosphoglycerate oxidoreductase activity|phosphoglyceric acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004617 GO:0004616 biolink:MolecularActivity phosphogluconate dehydrogenase (decarboxylating) activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. EC:1.1.1.44|MetaCyc:RXN-9952|RHEA:10116|Reactome:R-HSA-71299 go.json 6-phospho-D-gluconate dehydrogenase activity|6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)|6-phosphogluconate dehydrogenase (decarboxylating)|6-phosphogluconic carboxylase activity|6-phosphogluconic dehydrogenase activity|6PGD activity|phosphogluconic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004616 GO:0004619 biolink:MolecularActivity phosphoglycerate mutase activity Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. RHEA:15901|Reactome:R-HSA-71445|Reactome:R-HSA-71654 go.json D-phosphoglycerate 2,3-phosphomutase activity|PGA mutase activity|PGAM activity|PGM|phosphoglycerate phosphomutase activity|phosphoglyceromutase activity http://purl.obolibrary.org/obo/GO_0004619 GO:0004618 biolink:MolecularActivity phosphoglycerate kinase activity Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+. EC:2.7.2.3|KEGG_REACTION:R01512|MetaCyc:PHOSGLYPHOS-RXN|RHEA:14801|Reactome:R-HSA-70486|Reactome:R-HSA-71850 go.json 3-PGK|3-phosphoglycerate kinase activity|3-phosphoglycerate phosphokinase activity|3-phosphoglyceric acid kinase activity|3-phosphoglyceric acid phosphokinase activity|3-phosphoglyceric kinase activity|ATP-3-phospho-D-glycerate-1-phosphotransferase activity|ATP:3-phospho-D-glycerate 1-phosphotransferase activity|ATP:D-3-phosphoglycerate 1-phosphotransferase activity|PGK|glycerate 3-phosphate kinase activity|glycerophosphate kinase activity|phosphoglyceric acid kinase activity|phosphoglyceric kinase activity|phosphoglycerokinase activity http://purl.obolibrary.org/obo/GO_0004618 GO:0014049 biolink:BiologicalProcess positive regulation of glutamate secretion Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate. go.json activation of glutamate secretion|stimulation of glutamate secretion|up regulation of glutamate secretion|up-regulation of glutamate secretion|upregulation of glutamate secretion http://purl.obolibrary.org/obo/GO_0014049 GO:0038016 biolink:BiologicalProcess insulin receptor internalization A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell. go.json insulin receptor endocytosis http://purl.obolibrary.org/obo/GO_0038016 GO:0038015 biolink:BiologicalProcess positive regulation of insulin receptor signaling pathway by insulin receptor internalization Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane. go.json positive regulation of insulin receptor signalling pathway by insulin receptor internalization http://purl.obolibrary.org/obo/GO_0038015 GO:0014048 biolink:BiologicalProcess regulation of glutamate secretion Any process that modulates the frequency, rate or extent of the controlled release of glutamate. go.json http://purl.obolibrary.org/obo/GO_0014048 GO:0038018 biolink:BiologicalProcess Wnt receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. go.json Frizzled degradation|Wnt receptor breakdown|Wnt receptor catabolism|Wnt receptor degradation|negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation http://purl.obolibrary.org/obo/GO_0038018 GO:0014047 biolink:BiologicalProcess glutamate secretion The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. go.json http://purl.obolibrary.org/obo/GO_0014047 GO:0038017 biolink:BiologicalProcess Wnt receptor internalization A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell. go.json Wnt receptor endocytosis http://purl.obolibrary.org/obo/GO_0038017 GO:0014046 biolink:BiologicalProcess dopamine secretion The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. go.json http://purl.obolibrary.org/obo/GO_0014046 GO:0038019 biolink:BiologicalProcess Wnt receptor recycling The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. go.json Frizzled recycling http://purl.obolibrary.org/obo/GO_0038019 GO:0014041 biolink:BiologicalProcess regulation of neuron maturation Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. go.json http://purl.obolibrary.org/obo/GO_0014041 GO:0014040 biolink:BiologicalProcess positive regulation of Schwann cell differentiation Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation. go.json activation of Schwann cell differentiation|stimulation of Schwann cell differentiation|up regulation of Schwann cell differentiation|up-regulation of Schwann cell differentiation|upregulation of Schwann cell differentiation http://purl.obolibrary.org/obo/GO_0014040 GO:0038010 biolink:BiologicalProcess positive regulation of signal transduction by receptor internalization Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms. go.json positive regulation of signaling pathway by receptor endocytosis http://purl.obolibrary.org/obo/GO_0038010 GO:0038012 biolink:BiologicalProcess negative regulation of Wnt signaling pathway by Wnt receptor internalization Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction. go.json ligand-dependent internalization of Frizzled|negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis|negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization|negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization|negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization http://purl.obolibrary.org/obo/GO_0038012 GO:0014045 biolink:BiologicalProcess establishment of endothelial blood-brain barrier Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. go.json establishment of endothelial BBB|establishment of endothelial blood/brain barrier http://purl.obolibrary.org/obo/GO_0014045 GO:0014044 biolink:BiologicalProcess Schwann cell development The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. go.json http://purl.obolibrary.org/obo/GO_0014044 GO:0038011 biolink:BiologicalProcess negative regulation of signal transduction by receptor internalization Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands. go.json negative regulation of signaling pathway by receptor endocytosis http://purl.obolibrary.org/obo/GO_0038011 GO:0038014 biolink:BiologicalProcess negative regulation of insulin receptor signaling pathway by insulin receptor internalization Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation. go.json agonist-stimulated insulin receptor internalization|negative regulation of insulin receptor signalling pathway by insulin receptor internalization http://purl.obolibrary.org/obo/GO_0038014 GO:0014043 biolink:BiologicalProcess negative regulation of neuron maturation Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. go.json down regulation of neuron maturation|down-regulation of neuron maturation|downregulation of neuron maturation|inhibition of neuron maturation http://purl.obolibrary.org/obo/GO_0014043 GO:0014042 biolink:BiologicalProcess positive regulation of neuron maturation Any process that activates or increases the frequency, rate or extent of neuron maturation. go.json activation of neuron maturation|stimulation of neuron maturation|up regulation of neuron maturation|up-regulation of neuron maturation|upregulation of neuron maturation http://purl.obolibrary.org/obo/GO_0014042 GO:0038013 biolink:BiologicalProcess positive regulation of Wnt signaling pathway by Wnt receptor internalization Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway. go.json positive regulation of Wnt receptor signaling pathway by Frizzled internalization|positive regulation of Wnt receptor signaling pathway by LRP6 internalization|positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization|positive regulation of Wnt receptor signalling pathway by Wnt receptor endocytosis|positive regulation of Wnt-activated signaling pathway by Wnt receptor internalization http://purl.obolibrary.org/obo/GO_0038013 GO:0038005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038005 GO:0038004 biolink:BiologicalProcess epidermal growth factor receptor ligand maturation Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor. go.json EGFR ligand maturation|EGFR ligand maturation by peptide bond cleavage|EGFR ligand processing|epidermal growth factor receptor ligand processing|peptide bond cleavage involved in EGFR ligand maturation|peptide bond cleavage involved in epidermal growth factor receptor ligand maturation http://purl.obolibrary.org/obo/GO_0038004 GO:0014059 biolink:BiologicalProcess regulation of dopamine secretion Any process that modulates the frequency, rate or extent of the regulated release of dopamine. go.json http://purl.obolibrary.org/obo/GO_0014059 GO:0038007 biolink:BiologicalProcess netrin-activated signaling pathway The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. go.json netrin signaling pathway|netrin-activated signal transduction pathway|netrin-activated signalling pathway|netrin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0038007 GO:0014058 biolink:BiologicalProcess negative regulation of acetylcholine secretion, neurotransmission Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. go.json down regulation of acetylcholine secretion|down-regulation of acetylcholine secretion|downregulation of acetylcholine secretion|inhibition of acetylcholine secretion http://purl.obolibrary.org/obo/GO_0014058 GO:0014057 biolink:BiologicalProcess positive regulation of acetylcholine secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. go.json activation of acetylcholine secretion|stimulation of acetylcholine secretion|up regulation of acetylcholine secretion|up-regulation of acetylcholine secretion|upregulation of acetylcholine secretion http://purl.obolibrary.org/obo/GO_0014057 GO:0038006 biolink:MolecularActivity netrin receptor activity involved in chemoattraction Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin. go.json attractive netrin receptor activity|netrin receptor activity involved in positive chemotaxis http://purl.obolibrary.org/obo/GO_0038006 GO:0038009 biolink:BiologicalProcess regulation of signal transduction by receptor internalization Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway. go.json regulation of signaling pathway by receptor endocytosis http://purl.obolibrary.org/obo/GO_0038009 GO:0038008 biolink:BiologicalProcess TRAF-mediated signal transduction The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components. go.json TRAF signaling|TRAF-mediated intracellular signaling|TRAF-mediated signaling|TRAF-mediated signalling|tumor necrosis factor receptor-associated factor signal transduction|tumor necrosis factor receptor-associated factor signaling http://purl.obolibrary.org/obo/GO_0038008 GO:0014052 biolink:BiologicalProcess regulation of gamma-aminobutyric acid secretion Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. go.json regulation of GABA secretion http://purl.obolibrary.org/obo/GO_0014052 GO:0014051 biolink:BiologicalProcess gamma-aminobutyric acid secretion The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. go.json GABA secretion http://purl.obolibrary.org/obo/GO_0014051 GO:0014050 biolink:BiologicalProcess negative regulation of glutamate secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate. go.json down regulation of glutamate secretion|down-regulation of glutamate secretion|downregulation of glutamate secretion|inhibition of glutamate secretion http://purl.obolibrary.org/obo/GO_0014050 GO:0038001 biolink:BiologicalProcess paracrine signaling The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other. go.json paracrine signalling http://purl.obolibrary.org/obo/GO_0038001 GO:0014056 biolink:BiologicalProcess regulation of acetylcholine secretion, neurotransmission Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. go.json http://purl.obolibrary.org/obo/GO_0014056 GO:0014055 biolink:BiologicalProcess acetylcholine secretion, neurotransmission The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). go.json http://purl.obolibrary.org/obo/GO_0014055 GO:0038003 biolink:BiologicalProcess G protein-coupled opioid receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Wikipedia:Opioid_receptor go.json opioid receptor signaling pathway|opioid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0038003 GO:0014054 biolink:BiologicalProcess positive regulation of gamma-aminobutyric acid secretion Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. go.json activation of gamma-aminobutyric acid secretion|positive regulation of GABA secretion|stimulation of gamma-aminobutyric acid secretion|up regulation of gamma-aminobutyric acid secretion|up-regulation of gamma-aminobutyric acid secretion|upregulation of gamma-aminobutyric acid secretion http://purl.obolibrary.org/obo/GO_0014054 GO:0038002 biolink:BiologicalProcess endocrine signaling The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other. go.json endocrine signalling http://purl.obolibrary.org/obo/GO_0038002 GO:0014053 biolink:BiologicalProcess negative regulation of gamma-aminobutyric acid secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. go.json down regulation of gamma-aminobutyric acid secretion|down-regulation of gamma-aminobutyric acid secretion|downregulation of gamma-aminobutyric acid secretion|inhibition of gamma-aminobutyric acid secretion|negative regulation of GABA secretion http://purl.obolibrary.org/obo/GO_0014053 GO:0014027 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0014027 GO:0014026 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0014026 GO:0014025 biolink:BiologicalProcess neural keel formation The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. go.json http://purl.obolibrary.org/obo/GO_0014025 GO:0014024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0014024 GO:0014029 biolink:BiologicalProcess neural crest formation The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. go.json http://purl.obolibrary.org/obo/GO_0014029 GO:0014028 biolink:BiologicalProcess notochord formation The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. go.json http://purl.obolibrary.org/obo/GO_0014028 GO:0014023 biolink:BiologicalProcess neural rod formation The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. go.json http://purl.obolibrary.org/obo/GO_0014023 GO:0014022 biolink:BiologicalProcess neural plate elongation The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions. go.json http://purl.obolibrary.org/obo/GO_0014022 GO:0014021 biolink:BiologicalProcess secondary neural tube formation The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals. go.json medullary cord biosynthesis|medullary cord formation|medullary rod cavitation|neural rod formation|secondary neural tube rod cavitation|secondary neurulation http://purl.obolibrary.org/obo/GO_0014021 GO:0014020 biolink:BiologicalProcess primary neural tube formation The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. go.json neural rod cavitation|primary neural tube morphogenesis|primary neurulation http://purl.obolibrary.org/obo/GO_0014020 GO:0014038 biolink:BiologicalProcess regulation of Schwann cell differentiation Any process that modulates the frequency, rate or extent of Schwann cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0014038 GO:0014037 biolink:BiologicalProcess Schwann cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. go.json http://purl.obolibrary.org/obo/GO_0014037 GO:0014036 biolink:BiologicalProcess neural crest cell fate specification The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0014036 GO:0014035 biolink:BiologicalProcess neural crest cell fate determination The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0014035 GO:0014039 biolink:BiologicalProcess negative regulation of Schwann cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation. go.json down regulation of Schwann cell differentiation|down-regulation of Schwann cell differentiation|downregulation of Schwann cell differentiation|inhibition of Schwann cell differentiation http://purl.obolibrary.org/obo/GO_0014039 GO:0014030 biolink:BiologicalProcess mesenchymal cell fate commitment The process in which a cell becomes committed to become a mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0014030 GO:0014034 biolink:BiologicalProcess neural crest cell fate commitment The process in which a cell becomes committed to become a neural crest cell. go.json http://purl.obolibrary.org/obo/GO_0014034 GO:0014033 biolink:BiologicalProcess neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. go.json http://purl.obolibrary.org/obo/GO_0014033 GO:0014032 biolink:BiologicalProcess neural crest cell development The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0014032 GO:0014031 biolink:BiologicalProcess mesenchymal cell development The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. go.json http://purl.obolibrary.org/obo/GO_0014031 GO:0004689 biolink:MolecularActivity phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. EC:2.7.11.19|MetaCyc:2.7.11.19-RXN|Reactome:R-HSA-453337|Reactome:R-HSA-71541|Reactome:R-HSA-71588 go.json ATP:phosphorylase-b phosphotransferase activity|PHK|STK17|dephosphophosphorylase kinase activity|glycogen phosphorylase kinase activity|phosphorylase B kinase activity|phosphorylase kinase (phosphorylating) activity|phosphorylase kinase, intrinsic catalyst activity http://purl.obolibrary.org/obo/GO_0004689 GO:0004686 biolink:MolecularActivity elongation factor-2 kinase activity Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate. EC:2.7.11.20|MetaCyc:2.7.11.20-RXN|RHEA:21436 go.json ATP:elongation factor 2 phosphotransferase activity|Ca/CaM-kinase III activity|CaM kinase III activity|EF2K|STK19|calmodulin-dependent protein kinase III activity|eEF-2 kinase activity|eEF2 kinase activity|eEF2K|elongation factor 2 kinase activity|eukaryotic elongation factor 2 kinase activity http://purl.obolibrary.org/obo/GO_0004686 GO:0004685 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004685 GO:0004688 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004688 GO:0004687 biolink:MolecularActivity myosin light chain kinase activity Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. EC:2.7.11.18|MetaCyc:2.7.11.18-RXN|RHEA:22004|Reactome:R-HSA-445813|Reactome:R-HSA-5668978 go.json ATP:myosin-light-chain O-phosphotransferase|ATP:myosin-light-chain O-phosphotransferase activity|MLCK|MLCkase activity|STK18|calcium/calmodulin-dependent myosin light chain kinase activity|myosin kinase activity|myosin light chain protein kinase activity|myosin light-chain kinase|myosin light-chain kinase (phosphorylating)|myosin light-chain kinase (phosphorylating) activity|myosin light-chain kinase activity|myosin-light-chain kinase activity|smooth-muscle-myosin-light-chain kinase activity http://purl.obolibrary.org/obo/GO_0004687 GO:0004682 biolink:MolecularActivity obsolete protein kinase CK2 activity OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP. go.json casein kinase II activity|casein kinase II, catalytic activity|protein kinase CK2 activity|protein kinase CK2, intrinsic catalyst activity True http://purl.obolibrary.org/obo/GO_0004682 GO:0004681 biolink:MolecularActivity obsolete casein kinase I activity OBSOLETE. (Was not defined before being made obsolete). go.json casein kinase I activity True http://purl.obolibrary.org/obo/GO_0004681 GO:0004684 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004684 GO:0004683 biolink:MolecularActivity calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. EC:2.7.11.17|Reactome:R-HSA-111912|Reactome:R-HSA-111915|Reactome:R-HSA-416320|Reactome:R-HSA-442749|Reactome:R-HSA-9006992|Reactome:R-HSA-9617583|Reactome:R-HSA-9618750|Reactome:R-HSA-9619125|Reactome:R-HSA-9619355|Reactome:R-HSA-9619367|Reactome:R-HSA-9619478|Reactome:R-HSA-9619783 go.json ATP:caldesmon O-phosphotransferase activity|ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity|CAM PKII|Ca2+/CaM-dependent kinase activity|Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity|Ca2+/calmodulin-dependent protein kinase 1 activity|Ca2+/calmodulin-dependent protein kinase II activity|Ca2+/calmodulin-dependent protein kinase IV activity|Ca2+/calmodulin-dependent protein kinase activity|Ca2+/calmodulin-dependent protein kinase kinase activity|Ca2+/calmodulin-dependent protein kinase kinase beta activity|CaM kinase II activity|CaM kinase activity|CaM-regulated serine/threonine kinase activity|CaMKI|CaMKII|CaMKIV|CaMKKalpha|CaMKKbeta|STK20|calcium- and calmodulin-dependent protein kinase activity|calcium/calmodulin-dependent protein kinase activity|calcium/calmodulin-dependent protein kinase type II activity|caldesmon kinase (phosphorylating) activity|calmodulin regulated protein kinase activity|calmodulin-dependent kinase II activity|calmodulin-dependent protein kinase I activity|microtubule-associated protein 2 kinase activity|multifunctional calcium- and calmodulin-regulated protein kinase activity|multifunctional calcium/calmodulin regulated protein kinase activity http://purl.obolibrary.org/obo/GO_0004683 GO:0004680 biolink:MolecularActivity obsolete casein kinase activity OBSOLETE. (Was not defined before being made obsolete). go.json casein kinase activity True http://purl.obolibrary.org/obo/GO_0004680 GO:0014005 biolink:BiologicalProcess microglia development The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json microglial cell development http://purl.obolibrary.org/obo/GO_0014005 GO:0014004 biolink:BiologicalProcess microglia differentiation The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system. go.json microglial cell differentiation http://purl.obolibrary.org/obo/GO_0014004 GO:0014003 biolink:BiologicalProcess oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. go.json oligodendrocyte cell development http://purl.obolibrary.org/obo/GO_0014003 GO:0014002 biolink:BiologicalProcess astrocyte development The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. go.json astrocyte cell development http://purl.obolibrary.org/obo/GO_0014002 GO:0014009 biolink:BiologicalProcess glial cell proliferation The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. go.json glia proliferation http://purl.obolibrary.org/obo/GO_0014009 GO:0014008 biolink:BiologicalProcess positive regulation of microglia differentiation Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. go.json activation of microglia differentiation|positive regulation of microglial cell differentiation|stimulation of microglia differentiation|up regulation of microglia differentiation|up-regulation of microglia differentiation|upregulation of microglia differentiation http://purl.obolibrary.org/obo/GO_0014008 GO:0014007 biolink:BiologicalProcess negative regulation of microglia differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. go.json down regulation of microglia differentiation|down-regulation of microglia differentiation|downregulation of microglia differentiation|inhibition of microglia differentiation|negative regulation of microglial cell differentiation http://purl.obolibrary.org/obo/GO_0014007 GO:0014006 biolink:BiologicalProcess regulation of microglia differentiation Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. go.json regulation of microglial cell differentiation http://purl.obolibrary.org/obo/GO_0014006 GO:0014001 biolink:BiologicalProcess sclerenchyma cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable. go.json http://purl.obolibrary.org/obo/GO_0014001 GO:0004697 biolink:MolecularActivity diacylglycerol-dependent serine/threonine kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. EC:2.7.11.13|Reactome:R-HSA-1433508|Reactome:R-HSA-193703|Reactome:R-HSA-198314|Reactome:R-HSA-2179413|Reactome:R-HSA-2730863|Reactome:R-HSA-374664|Reactome:R-HSA-429698|Reactome:R-HSA-450533|Reactome:R-HSA-450550|Reactome:R-HSA-5138432|Reactome:R-HSA-5218805|Reactome:R-HSA-5218823|Reactome:R-HSA-5229194|Reactome:R-HSA-5623667|Reactome:R-HSA-5625784|Reactome:R-HSA-5671749|Reactome:R-HSA-74615|Reactome:R-HSA-751040|Reactome:R-HSA-8932284|Reactome:R-HSA-8934446|Reactome:R-HSA-9010681|Reactome:R-HSA-9021357|Reactome:R-HSA-909552|Reactome:R-HSA-927889|Reactome:R-HSA-9626817|Reactome:R-HSA-9632858|Reactome:R-HSA-9796053 go.json ATP:protein phosphotransferase (diacylglycerol-dependent) activity|PKC|PKC activity|PKCalpha|PKCbeta|PKCdelta|PKCepsilon|PKCgamma|Pkc1p|STK24|cPKC|cPKCalpha|cPKCbeta|cPKCgamma|diacylglycerol-activated phospholipid-dependent PKC activity|diacylglycerol-activated phospholipid-dependent protein kinase C activity|nPKC|nPKCdelta|nPKCepsilon|nPKCeta|nPKCtheta|protein kinase Cepsilon activity http://purl.obolibrary.org/obo/GO_0004697 GO:0004696 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004696 GO:0004699 biolink:MolecularActivity diacylglycerol-dependent, calcium-independent serine/threonine kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. Reactome:R-HSA-5607740 go.json calcium-independent PKC activity|novel protein kinase C activity http://purl.obolibrary.org/obo/GO_0004699 GO:0004698 biolink:MolecularActivity calcium,diacylglycerol-dependent serine/threonine kinase activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. Reactome:R-HSA-114683|Reactome:R-HSA-114684|Reactome:R-HSA-416639|Reactome:R-HSA-421007|Reactome:R-HSA-8986937|Reactome:R-HSA-9005561 go.json calcium-dependent PKC activity|conventional protein kinase C activity http://purl.obolibrary.org/obo/GO_0004698 GO:0004693 biolink:MolecularActivity cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. EC:2.7.11.22|Reactome:R-HSA-1226094|Reactome:R-HSA-1226095|Reactome:R-HSA-174079|Reactome:R-HSA-174122|Reactome:R-HSA-174132|Reactome:R-HSA-174251|Reactome:R-HSA-180047|Reactome:R-HSA-187520|Reactome:R-HSA-187916|Reactome:R-HSA-187948|Reactome:R-HSA-187959|Reactome:R-HSA-188390|Reactome:R-HSA-1912391|Reactome:R-HSA-2172183|Reactome:R-HSA-2220971|Reactome:R-HSA-2245218|Reactome:R-HSA-2294600|Reactome:R-HSA-2430533|Reactome:R-HSA-2468287|Reactome:R-HSA-2468293|Reactome:R-HSA-2514854|Reactome:R-HSA-2984220|Reactome:R-HSA-2990882|Reactome:R-HSA-3788705|Reactome:R-HSA-380278|Reactome:R-HSA-4086410|Reactome:R-HSA-4088024|Reactome:R-HSA-5195402|Reactome:R-HSA-5244669|Reactome:R-HSA-5692755|Reactome:R-HSA-6793661|Reactome:R-HSA-6797606|Reactome:R-HSA-6805109|Reactome:R-HSA-68944|Reactome:R-HSA-69005|Reactome:R-HSA-69227|Reactome:R-HSA-69754|Reactome:R-HSA-69756|Reactome:R-HSA-9008412|Reactome:R-HSA-9009282|Reactome:R-HSA-9624800|Reactome:R-HSA-9686521 go.json ATP:cyclin phosphotransferase activity|CDK|CDK activity|CDK, catalytic subunit activity|Cdk-activating protein kinase activity|D-type cyclin kinase activity|cdc2 kinase activity|cdk-activating kinase activity|cyclin D-cdk6 kinase activity|cyclin D-dependent kinase activity|cyclin E kinase activity|cyclin-A associated kinase activity|cyclin-dependent kinase 6 activity|cyclin-dependent kinase activity|cyclin-dependent kinase-2 activity|cyclin-dependent kinase-4 activity|cyclin-dependent protein kinase activity|cyclin-dependent protein kinase, intrinsic catalyst activity|neuronal cdc2-like kinase activity http://purl.obolibrary.org/obo/GO_0004693 GO:0004692 biolink:MolecularActivity cGMP-dependent protein kinase activity cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. EC:2.7.11.12|Reactome:R-HSA-1475422|Reactome:R-HSA-1497853|Reactome:R-HSA-418442|Reactome:R-HSA-418549 go.json 3':5'-cyclic GMP-dependent protein kinase activity|ATP:protein phosphotransferase (cGMP-dependent) activity|PKG|PKG 1alpha|PKG 1beta|PKG II|STK23|cGMP-dependent protein kinase ibeta activity|guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity http://purl.obolibrary.org/obo/GO_0004692 GO:0004695 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004695 GO:0004694 biolink:MolecularActivity eukaryotic translation initiation factor 2alpha kinase activity Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. go.json http://purl.obolibrary.org/obo/GO_0004694 GO:0004691 biolink:MolecularActivity cAMP-dependent protein kinase activity cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. EC:2.7.11.11|Reactome:R-HSA-163672|Reactome:R-HSA-163676|Reactome:R-HSA-163773|Reactome:R-HSA-177275|Reactome:R-HSA-177284|Reactome:R-HSA-432232|Reactome:R-HSA-5610717|Reactome:R-HSA-5610720|Reactome:R-HSA-5610741|Reactome:R-HSA-5617179|Reactome:R-HSA-5617182|Reactome:R-HSA-5687088|Reactome:R-HSA-913451 go.json 3',5' cAMP-dependent protein kinase activity|3',5'-cAMP-dependent protein kinase activity|AMPK|ATP:protein phosphotransferase (cAMP-dependent) activity|PKA|PKA C|STK22|adenosine 3',5'-cyclophosphate-dependent protein kinase activity|cAMP-dependent protein kinase, intrinsic catalyst activity|cyclic AMP-dependent protein kinase activity|protein kinase A activity http://purl.obolibrary.org/obo/GO_0004691 GO:0004690 biolink:MolecularActivity cyclic nucleotide-dependent protein kinase activity cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. go.json http://purl.obolibrary.org/obo/GO_0004690 GO:0014016 biolink:BiologicalProcess neuroblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. go.json http://purl.obolibrary.org/obo/GO_0014016 GO:0014015 biolink:BiologicalProcess positive regulation of gliogenesis Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. go.json activation of gliogenesis|stimulation of gliogenesis|up regulation of gliogenesis|up-regulation of gliogenesis|upregulation of gliogenesis http://purl.obolibrary.org/obo/GO_0014015 GO:0014014 biolink:BiologicalProcess negative regulation of gliogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. go.json down regulation of gliogenesis|down-regulation of gliogenesis|downregulation of gliogenesis|inhibition of gliogenesis http://purl.obolibrary.org/obo/GO_0014014 GO:0014013 biolink:BiologicalProcess regulation of gliogenesis Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. go.json http://purl.obolibrary.org/obo/GO_0014013 GO:0014019 biolink:BiologicalProcess neuroblast development The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. go.json http://purl.obolibrary.org/obo/GO_0014019 GO:0014018 biolink:BiologicalProcess neuroblast fate specification The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0014018 GO:0014017 biolink:BiologicalProcess neuroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast. go.json http://purl.obolibrary.org/obo/GO_0014017 GO:0014012 biolink:BiologicalProcess peripheral nervous system axon regeneration The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury. go.json axon regeneration in peripheral nervous system http://purl.obolibrary.org/obo/GO_0014012 GO:0014011 biolink:BiologicalProcess Schwann cell proliferation involved in axon regeneration The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system. go.json http://purl.obolibrary.org/obo/GO_0014011 GO:0014010 biolink:BiologicalProcess Schwann cell proliferation The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. go.json http://purl.obolibrary.org/obo/GO_0014010 GO:0004668 biolink:MolecularActivity protein-arginine deiminase activity Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. EC:3.5.3.15|MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN|RHEA:18089|Reactome:R-HSA-1183128|Reactome:R-HSA-3247569 go.json peptidylarginine deiminase activity|protein-L-arginine iminohydrolase activity http://purl.obolibrary.org/obo/GO_0004668 GO:0004667 biolink:MolecularActivity prostaglandin-D synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). EC:5.3.99.2|KEGG_REACTION:R02266|MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN|RHEA:10600|Reactome:R-HSA-2161620|Reactome:R-HSA-2161701 go.json (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity|PGD2 synthase activity|PGH-PGD isomerase activity|prostaglandin D2 synthase activity|prostaglandin-H2 D-isomerase activity|prostaglandin-R-prostaglandin D isomerase activity http://purl.obolibrary.org/obo/GO_0004667 GO:0004664 biolink:MolecularActivity prephenate dehydratase activity Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. EC:4.2.1.51|MetaCyc:PREPHENATEDEHYDRAT-RXN|RHEA:21648 go.json prephenate hydro-lyase (decarboxylating)|prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming) http://purl.obolibrary.org/obo/GO_0004664 GO:0004663 biolink:MolecularActivity Rab geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. EC:2.5.1.60|MetaCyc:RXN-19995|MetaCyc:RXN-19996|MetaCyc:RXN-19997 go.json GGTase-II activity|GGTaseII activity|Rab-protein geranylgeranyltransferase activity|RabGGTase activity|geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity|protein geranylgeranyltransferase type II activity|type II protein geranyl-geranyltransferase activity http://purl.obolibrary.org/obo/GO_0004663 GO:0004666 biolink:MolecularActivity prostaglandin-endoperoxide synthase activity Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. EC:1.14.99.1|MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN|RHEA:23728|Reactome:R-HSA-140355|Reactome:R-HSA-2309787 go.json (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity|(PG)H synthase activity|PG synthetase activity|fatty acid cyclooxygenase activity|prostaglandin G/H synthase activity|prostaglandin endoperoxide synthetase activity|prostaglandin synthase activity|prostaglandin synthetase activity http://purl.obolibrary.org/obo/GO_0004666 GO:0004665 biolink:MolecularActivity prephenate dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH. EC:1.3.1.13|KEGG_REACTION:R01730|MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN|RHEA:21640 go.json prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|prephenate:NADP+ oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0004665 GO:0004660 biolink:MolecularActivity protein farnesyltransferase activity Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. EC:2.5.1.58|MetaCyc:RXN-17573|RHEA:13345|Reactome:R-HSA-2530501|Reactome:R-HSA-9647978 go.json CAAX farnesyltransferase activity|FTase activity|farnesyl-diphosphate:protein-cysteine farnesyltransferase activity|protein-cysteine farnesyltransferase activity http://purl.obolibrary.org/obo/GO_0004660 GO:0004662 biolink:MolecularActivity CAAX-protein geranylgeranyltransferase activity Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. EC:2.5.1.59|MetaCyc:RXN-3701 go.json GGTase-I activity|GGTaseI activity|geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity|geranylgeranyltransferase type I activity|protein geranylgeranyltransferase type I|type I protein geranyl-geranyltransferase activity http://purl.obolibrary.org/obo/GO_0004662 GO:0004661 biolink:MolecularActivity protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. go.json protein-cysteine geranylgeranyltransferase activity http://purl.obolibrary.org/obo/GO_0004661 GO:0004679 biolink:MolecularActivity AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. EC:2.7.11.11|Reactome:R-HSA-1592244|Reactome:R-HSA-163691|Reactome:R-HSA-200423|Reactome:R-HSA-380927|Reactome:R-HSA-447074|Reactome:R-HSA-5673768|Reactome:R-HSA-6805470 go.json 5'-AMP-activated protein kinase activity|AMPK activity|SNF1A/AMP-activated protein kinase activity http://purl.obolibrary.org/obo/GO_0004679 GO:0004678 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004678 GO:0004675 biolink:MolecularActivity transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. EC:2.7.11.30|MetaCyc:2.7.11.30-RXN|RHEA:18673|Reactome:R-HSA-170868|Reactome:R-HSA-198732|Reactome:R-HSA-201476 go.json receptor protein serine/threonine kinase activity|receptor serine/threonine protein kinase activity http://purl.obolibrary.org/obo/GO_0004675 GO:0004674 biolink:MolecularActivity protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. EC:2.7.11.1|MetaCyc:PROTEIN-KINASE-RXN|Reactome:R-HSA-109702|Reactome:R-HSA-109822|Reactome:R-HSA-109823|Reactome:R-HSA-109860|Reactome:R-HSA-109862|Reactome:R-HSA-111919|Reactome:R-HSA-111970|Reactome:R-HSA-112342|Reactome:R-HSA-112381|Reactome:R-HSA-1168635|Reactome:R-HSA-1168638|Reactome:R-HSA-1168641|Reactome:R-HSA-1181149|Reactome:R-HSA-1181156|Reactome:R-HSA-1181355|Reactome:R-HSA-1225894|Reactome:R-HSA-1358791|Reactome:R-HSA-1362270|Reactome:R-HSA-139908|Reactome:R-HSA-139918|Reactome:R-HSA-1445144|Reactome:R-HSA-1449597|Reactome:R-HSA-1454699|Reactome:R-HSA-1458463|Reactome:R-HSA-1549526|Reactome:R-HSA-156673|Reactome:R-HSA-156678|Reactome:R-HSA-156682|Reactome:R-HSA-156699|Reactome:R-HSA-156723|Reactome:R-HSA-1592233|Reactome:R-HSA-162363|Reactome:R-HSA-162657|Reactome:R-HSA-163010|Reactome:R-HSA-1632857|Reactome:R-HSA-163416|Reactome:R-HSA-163418|Reactome:R-HSA-1638803|Reactome:R-HSA-164151|Reactome:R-HSA-165162|Reactome:R-HSA-165182|Reactome:R-HSA-165692|Reactome:R-HSA-165718|Reactome:R-HSA-165726|Reactome:R-HSA-165758|Reactome:R-HSA-165766|Reactome:R-HSA-165777|Reactome:R-HSA-166119|Reactome:R-HSA-166245|Reactome:R-HSA-166284|Reactome:R-HSA-166286|Reactome:R-HSA-167084|Reactome:R-HSA-167098|Reactome:R-HSA-168053|Reactome:R-HSA-168140|Reactome:R-HSA-168184|Reactome:R-HSA-170055|Reactome:R-HSA-170076|Reactome:R-HSA-170087|Reactome:R-HSA-170116|Reactome:R-HSA-170126|Reactome:R-HSA-170977|Reactome:R-HSA-174119|Reactome:R-HSA-174174|Reactome:R-HSA-176116|Reactome:R-HSA-176298|Reactome:R-HSA-187688|Reactome:R-HSA-187949|Reactome:R-HSA-188350|Reactome:R-HSA-193647|Reactome:R-HSA-193705|Reactome:R-HSA-195275|Reactome:R-HSA-195283|Reactome:R-HSA-195287|Reactome:R-HSA-195300|Reactome:R-HSA-195318|Reactome:R-HSA-198270|Reactome:R-HSA-198347|Reactome:R-HSA-198371|Reactome:R-HSA-198599|Reactome:R-HSA-198609|Reactome:R-HSA-198611|Reactome:R-HSA-198613|Reactome:R-HSA-198621|Reactome:R-HSA-198640|Reactome:R-HSA-198669|Reactome:R-HSA-198731|Reactome:R-HSA-198746|Reactome:R-HSA-198756|Reactome:R-HSA-199298|Reactome:R-HSA-199299|Reactome:R-HSA-199839|Reactome:R-HSA-199863|Reactome:R-HSA-199895|Reactome:R-HSA-199910|Reactome:R-HSA-199917|Reactome:R-HSA-199929|Reactome:R-HSA-199935|Reactome:R-HSA-200143|Reactome:R-HSA-200421|Reactome:R-HSA-201677|Reactome:R-HSA-201691|Reactome:R-HSA-201717|Reactome:R-HSA-202222|Reactome:R-HSA-202437|Reactome:R-HSA-202459|Reactome:R-HSA-202500|Reactome:R-HSA-202510|Reactome:R-HSA-202541|Reactome:R-HSA-2028284|Reactome:R-HSA-2028555|Reactome:R-HSA-2028583|Reactome:R-HSA-2028589|Reactome:R-HSA-2028591|Reactome:R-HSA-2028598|Reactome:R-HSA-2028629|Reactome:R-HSA-2028635|Reactome:R-HSA-2028661|Reactome:R-HSA-2028670|Reactome:R-HSA-2028673|Reactome:R-HSA-2028675|Reactome:R-HSA-2028679|Reactome:R-HSA-2029454|Reactome:R-HSA-2029460|Reactome:R-HSA-2029469|Reactome:R-HSA-2060328|Reactome:R-HSA-209087|Reactome:R-HSA-211164|Reactome:R-HSA-211583|Reactome:R-HSA-211650|Reactome:R-HSA-2168079|Reactome:R-HSA-2176475|Reactome:R-HSA-2214351|Reactome:R-HSA-2243938|Reactome:R-HSA-2243942|Reactome:R-HSA-2294580|Reactome:R-HSA-2396007|Reactome:R-HSA-2399941|Reactome:R-HSA-2399966|Reactome:R-HSA-2399969|Reactome:R-HSA-2399977|Reactome:R-HSA-2399981|Reactome:R-HSA-2399982|Reactome:R-HSA-2399985|Reactome:R-HSA-2399988|Reactome:R-HSA-2399992|Reactome:R-HSA-2399996|Reactome:R-HSA-2399999|Reactome:R-HSA-2400001|Reactome:R-HSA-2422927|Reactome:R-HSA-2430535|Reactome:R-HSA-2466068|Reactome:R-HSA-2470508|Reactome:R-HSA-2529020|Reactome:R-HSA-2562526|Reactome:R-HSA-2574840|Reactome:R-HSA-2730856|Reactome:R-HSA-2730868|Reactome:R-HSA-2730876|Reactome:R-HSA-2730896|Reactome:R-HSA-2730900|Reactome:R-HSA-2984226|Reactome:R-HSA-2984258|Reactome:R-HSA-2990880|Reactome:R-HSA-2993898|Reactome:R-HSA-3000310|Reactome:R-HSA-3000327|Reactome:R-HSA-3132737|Reactome:R-HSA-3209160|Reactome:R-HSA-3222006|Reactome:R-HSA-3222020|Reactome:R-HSA-3228469|Reactome:R-HSA-3229102|Reactome:R-HSA-3229152|Reactome:R-HSA-3239014|Reactome:R-HSA-3239019|Reactome:R-HSA-3249371|Reactome:R-HSA-3371435|Reactome:R-HSA-3371531|Reactome:R-HSA-3371567|Reactome:R-HSA-349426|Reactome:R-HSA-349444|Reactome:R-HSA-349455|Reactome:R-HSA-374696|Reactome:R-HSA-3769394|Reactome:R-HSA-377186|Reactome:R-HSA-3772435|Reactome:R-HSA-380272|Reactome:R-HSA-381091|Reactome:R-HSA-381111|Reactome:R-HSA-3857328|Reactome:R-HSA-3857329|Reactome:R-HSA-3858480|Reactome:R-HSA-389756|Reactome:R-HSA-392752|Reactome:R-HSA-3928577|Reactome:R-HSA-3928608|Reactome:R-HSA-3928616|Reactome:R-HSA-3928620|Reactome:R-HSA-3928625|Reactome:R-HSA-3928640|Reactome:R-HSA-399939|Reactome:R-HSA-399944|Reactome:R-HSA-399950|Reactome:R-HSA-399951|Reactome:R-HSA-399952|Reactome:R-HSA-399978|Reactome:R-HSA-400382|Reactome:R-HSA-4088134|Reactome:R-HSA-419083|Reactome:R-HSA-419087|Reactome:R-HSA-419197|Reactome:R-HSA-419644|Reactome:R-HSA-428961|Reactome:R-HSA-429016|Reactome:R-HSA-429714|Reactome:R-HSA-432110|Reactome:R-HSA-4332358|Reactome:R-HSA-4332363|Reactome:R-HSA-4332388|Reactome:R-HSA-4411383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e:R-HSA-9632868|Reactome:R-HSA-9633008|Reactome:R-HSA-9633742|Reactome:R-HSA-9634702|Reactome:R-HSA-9645535|Reactome:R-HSA-9648089|Reactome:R-HSA-9648883|Reactome:R-HSA-9648888|Reactome:R-HSA-9652165|Reactome:R-HSA-9653503|Reactome:R-HSA-9656214|Reactome:R-HSA-9656215|Reactome:R-HSA-9662823|Reactome:R-HSA-9673346|Reactome:R-HSA-9683664|Reactome:R-HSA-9699579|Reactome:R-HSA-9705320|Reactome:R-HSA-9705323|Reactome:R-HSA-9725030|Reactome:R-HSA-9729260|Reactome:R-HSA-9729300|Reactome:R-HSA-9729318|Reactome:R-HSA-9731111|Reactome:R-HSA-9734547|Reactome:R-HSA-975125|Reactome:R-HSA-975134|Reactome:R-HSA-975160|Reactome:R-HSA-975170|Reactome:R-HSA-975180|Reactome:R-HSA-9758486|Reactome:R-HSA-975853|Reactome:R-HSA-975861|Reactome:R-HSA-975865|Reactome:R-HSA-975874|Reactome:R-HSA-975878|Reactome:R-HSA-9762094|Reactome:R-HSA-9766532|Reactome:R-HSA-9769115|Reactome:R-HSA-9773803|Reactome:R-HSA-9796067|Reactome:R-HSA-9796081|Reactome:R-HSA-9815501|Reactome:R-HSA-9817397|Reactome:R-HSA-9818789|Reactome:R-HSA-9819106 go.json protein serine kinase activity|protein serine-threonine kinase activity|protein threonine kinase activity|protein-serine kinase activity|serine kinase activity|serine protein kinase activity|serine(threonine) protein kinase activity|serine-specific protein kinase activity|serine/threonine protein kinase activity|threonine-specific protein kinase activity http://purl.obolibrary.org/obo/GO_0004674 GO:0004677 biolink:MolecularActivity DNA-dependent protein kinase activity DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. go.json http://purl.obolibrary.org/obo/GO_0004677 GO:0004676 biolink:MolecularActivity 3-phosphoinositide-dependent protein kinase activity Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. Reactome:R-HSA-437195 go.json PDK activity|phosphatidylinositol-3-phosphate protein kinase activity http://purl.obolibrary.org/obo/GO_0004676 GO:0004671 biolink:MolecularActivity protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. EC:2.1.1.100|KEGG_REACTION:R04496|MetaCyc:2.1.1.100-RXN|RHEA:21672|Reactome:R-HSA-6788650|Reactome:R-HSA-9647977 go.json S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity|S-farnesylcysteine methyltransferase activity|farnesyl cysteine C-terminal methyltransferase activity|farnesyl-protein carboxymethyltransferase activity|farnesylated protein C-terminal O-methyltransferase activity|isoprenylated protein methyltransferase activity|isoprenylcysteine carboxylmethyltransferase activity|prenylated protein carboxyl methyltransferase activity|prenylated protein methyltransferase activity|prenylcysteine carboxyl methyltransferase activity|prenylcysteine carboxylmethyltransferase activity|prenylcysteine carboxymethyltransferase activity|prenylcysteine methyltransferase activity|protein C-terminal farnesylcysteine O-methyltransferase activity|protein S-farnesylcysteine C-terminal methyltransferase activity|protein-S-isoprenylcysteine O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0004671 GO:0004673 biolink:MolecularActivity protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. EC:2.7.13.3|MetaCyc:2.7.13.3-RXN go.json ATP:protein-L-histidine N-phosphotransferase activity|histidine kinase activity|histidine protein kinase activity|protein kinase (histidine)|protein-histidine kinase activity http://purl.obolibrary.org/obo/GO_0004673 GO:0004672 biolink:MolecularActivity protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. Reactome:R-HSA-156832|Reactome:R-HSA-937034|Reactome:R-HSA-9604606|Reactome:R-HSA-9673284|Reactome:R-HSA-9732753|Reactome:R-HSA-975139|Reactome:R-HSA-9833820|Reactome:R-HSA-9835885|Reactome:R-HSA-9836159|Reactome:R-HSA-9836184|Reactome:R-HSA-9836322|Reactome:R-HSA-9836362|Reactome:R-HSA-9836383|Reactome:R-HSA-9836404|Reactome:R-HSA-9836435|Reactome:R-HSA-9836449|Reactome:R-HSA-9836515|Reactome:R-HSA-9836617|Reactome:R-HSA-9836664 go.json protamine kinase activity http://purl.obolibrary.org/obo/GO_0004672 goslim_candida GO:0038195 biolink:BiologicalProcess urokinase plasminogen activator signaling pathway The series of molecular signals initiated by urokinase plasminogen activator binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json uPA signaling pathway http://purl.obolibrary.org/obo/GO_0038195 GO:0038194 biolink:BiologicalProcess thyroid-stimulating hormone signaling pathway A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TSH signaling pathway|thyrotropin signaling pathway http://purl.obolibrary.org/obo/GO_0038194 GO:0038197 biolink:CellularComponent type I interferon receptor complex A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). go.json interferon-alpha/beta receptor complex http://purl.obolibrary.org/obo/GO_0038197 GO:0038196 biolink:BiologicalProcess type III interferon-mediated signaling pathway The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far. go.json interferon lambda signaling pathway|type III interferon signaling pathway|type III interferon-activated signaling pathway http://purl.obolibrary.org/obo/GO_0038196 GO:0038199 biolink:MolecularActivity ethylene receptor activity Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity. go.json C2H4 receptor activity|ethylene response sensor http://purl.obolibrary.org/obo/GO_0038199 GO:0038198 biolink:MolecularActivity auxin receptor activity Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone). go.json http://purl.obolibrary.org/obo/GO_0038198 GO:0038191 biolink:MolecularActivity neuropilin binding Binding to a member of the neuropilin family. go.json Nrp binding|Nrp ligand|neuropilin-binding http://purl.obolibrary.org/obo/GO_0038191 GO:0038190 biolink:BiologicalProcess VEGF-activated neuropilin signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json VEGF-Npn-1 signaling|vascular endothelial growth factor-activated neuropilin signaling pathway http://purl.obolibrary.org/obo/GO_0038190 GO:0038193 biolink:BiologicalProcess thromboxane A2 signaling pathway A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TXA(2) receptor signaling|TXA2 signaling http://purl.obolibrary.org/obo/GO_0038193 GO:0038192 biolink:BiologicalProcess gastric inhibitory peptide signaling pathway A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json GIP signaling|gastric inhibitory polypeptide receptor signaling pathway|glucose-dependent insulinotropic polypeptide signaling http://purl.obolibrary.org/obo/GO_0038192 GO:0038184 biolink:BiologicalProcess cell surface bile acid receptor signaling pathway The series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json membrane bile acid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038184 GO:0038183 biolink:BiologicalProcess bile acid signaling pathway The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json http://purl.obolibrary.org/obo/GO_0038183 GO:0038186 biolink:MolecularActivity lithocholic acid receptor activity Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity. go.json LCA receptor activity http://purl.obolibrary.org/obo/GO_0038186 GO:0038185 biolink:BiologicalProcess intracellular bile acid receptor signaling pathway The series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json nuclear bile acid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038185 GO:0038188 biolink:BiologicalProcess cholecystokinin signaling pathway A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Wikipedia:Cholecystokinin go.json CCK signaling|cholecystokinin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038188 GO:0038187 biolink:MolecularActivity pattern recognition receptor activity Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. Wikipedia:Pattern_recognition_receptor go.json MAMP receptor activity|PAMP receptor activity|PRR|PRR activity|macrophage receptor activity|microbe-associated molecular pattern receptor activity|pathogen associated molecular pattern receptor activity|signaling pattern recognition receptor activity http://purl.obolibrary.org/obo/GO_0038187 GO:0038189 biolink:BiologicalProcess neuropilin signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json Npn signaling http://purl.obolibrary.org/obo/GO_0038189 GO:0038180 biolink:BiologicalProcess nerve growth factor signaling pathway The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Wikipedia:Nerve_growth_factor go.json NGF signaling pathway|nerve growth factor signalling pathway http://purl.obolibrary.org/obo/GO_0038180 GO:0038182 biolink:MolecularActivity G protein-coupled bile acid receptor activity Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. Wikipedia:G_protein-coupled_bile_acid_receptor go.json G-protein coupled bile acid receptor activity|cell surface bile acid receptor|membrane bile acid receptor activity http://purl.obolibrary.org/obo/GO_0038182 GO:0038181 biolink:MolecularActivity bile acid receptor activity Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. go.json http://purl.obolibrary.org/obo/GO_0038181 GO:0038173 biolink:BiologicalProcess interleukin-17A-mediated signaling pathway The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-17A-mediated signaling pathway|IL17A signaling pathway|interleukin-17A signaling pathway|interleukin-17A-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038173 GO:0038172 biolink:BiologicalProcess interleukin-33-mediated signaling pathway The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-33-mediated signaling pathway|IL33 signaling pathway|interleukin-33 signaling pathway|interleukin-33-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038172 GO:0038175 biolink:BiologicalProcess negative regulation of SREBP signaling pathway in response to increased oxygen levels Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels. go.json negative regulation of SREBP-mediated signaling pathway in presence of oxygen|negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels http://purl.obolibrary.org/obo/GO_0038175 GO:0038174 biolink:MolecularActivity interleukin-17A receptor activity Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0038174 GO:0038177 biolink:MolecularActivity death receptor agonist activity Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor. go.json death receptor activator activity http://purl.obolibrary.org/obo/GO_0038177 GO:0038176 biolink:BiologicalProcess positive regulation of SREBP signaling pathway in response to decreased oxygen levels Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels. go.json positive regulation of SREBP-mediated signaling pathway in absence of oxygen|positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels http://purl.obolibrary.org/obo/GO_0038176 GO:0038179 biolink:BiologicalProcess neurotrophin signaling pathway The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. go.json neurotrophin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038179 GO:0038178 biolink:BiologicalProcess complement component C5a signaling pathway A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor. go.json complement component C5a-induced signaling pathway http://purl.obolibrary.org/obo/GO_0038178 GO:0038171 biolink:BiologicalProcess cannabinoid signaling pathway A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. go.json cannabinoid receptor signaling pathway|cannabinoid-activated signaling pathway|cannabinoid-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0038171 GO:0038170 biolink:BiologicalProcess somatostatin signaling pathway A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription. go.json SRIF signaling pathway|SST signaling pathway|somatostatin signalling pathway|somatostatin-activated somatostatin receptor signaling pathway|somatostatin-mediated signaling pathway|somatotrophin release inhibiting factor signaling pathway http://purl.obolibrary.org/obo/GO_0038170 GO:0038169 biolink:BiologicalProcess somatostatin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json SST receptor signaling pathway|SSTR signaling pathway http://purl.obolibrary.org/obo/GO_0038169 GO:0038162 biolink:BiologicalProcess erythropoietin-mediated signaling pathway The series of molecular signals initiated by erythropoietin (EPO) binding to the erythropoietin receptor (EPO-R) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json EPO-R signaling pathway|erythropoietin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038162 GO:0038161 biolink:BiologicalProcess prolactin signaling pathway The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json PRL signaling pathway|prolactin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0038161 GO:0038164 biolink:MolecularActivity thrombopoietin receptor activity Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0038164 GO:0038163 biolink:BiologicalProcess thrombopoietin-mediated signaling pathway The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json THPO signaling pathway|THPO/MPL signaling pathway|thrombopoietin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038163 GO:0038166 biolink:BiologicalProcess angiotensin-activated signaling pathway A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json angiotensin II-mediated signaling pathway|angiotensin receptor signaling pathway|angiotensin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0038166 GO:0038165 biolink:BiologicalProcess oncostatin-M-mediated signaling pathway The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways. go.json OSM signaling pathway|oncostatin-M signaling pathway http://purl.obolibrary.org/obo/GO_0038165 GO:0038168 biolink:BiologicalProcess obsolete epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal transmitted via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB. go.json EGFR signaling pathway via IKK-dependent activation of NF-kappaB|EGFR signaling pathway via IKK/NF-kappaB cascade True http://purl.obolibrary.org/obo/GO_0038168 GO:0038167 biolink:BiologicalProcess obsolete epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal transmitted via the activation of the transcription factor NF-kappaB. go.json EGFR signaling pathway via activation of NF-kappaB|epidermal growth factor receptor signalling pathway via positive regulation of NF-kappaB transcription factor activity True http://purl.obolibrary.org/obo/GO_0038167 GO:0038160 biolink:BiologicalProcess CXCL12-activated CXCR4 signaling pathway The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CXCL12-activated CXCR4 signalling pathway http://purl.obolibrary.org/obo/GO_0038160 GO:0038159 biolink:BiologicalProcess C-X-C chemokine receptor CXCR4 signaling pathway The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CXCR4 signaling pathway http://purl.obolibrary.org/obo/GO_0038159 GO:0038158 biolink:BiologicalProcess granulocyte colony-stimulating factor signaling pathway The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R). go.json CSF3 signaling pathway|G-CSF receptor signaling pathway|G-CSF signaling pathway|granulocyte colony-stimulating factor receptor signaling pathway|granulocyte colony-stimulating factor signalling pathway http://purl.obolibrary.org/obo/GO_0038158 GO:0038151 biolink:BiologicalProcess CCL2-activated CCR2 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CCL2/CCR2 signaling pathway http://purl.obolibrary.org/obo/GO_0038151 GO:0038150 biolink:BiologicalProcess C-C chemokine receptor CCR2 signaling pathway The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json C-C chemokine receptor type 2 signaling pathway http://purl.obolibrary.org/obo/GO_0038150 GO:0038153 biolink:BiologicalProcess CCL2-activated CCR4 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CCL2/CCR4 signaling pathway http://purl.obolibrary.org/obo/GO_0038153 GO:0038152 biolink:BiologicalProcess C-C chemokine receptor CCR4 signaling pathway The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json C-C chemokine receptor type 4 signaling pathway|chemokine receptor CCR4 signaling pathway http://purl.obolibrary.org/obo/GO_0038152 GO:0038155 biolink:BiologicalProcess interleukin-23-mediated signaling pathway The series of molecular signals initiated by interleukin-23 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-23-mediated signaling pathway|interleukin-23-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038155 GO:0038154 biolink:BiologicalProcess interleukin-11-mediated signaling pathway The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-11-mediated signaling pathway|interleukin-11-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038154 GO:0038157 biolink:BiologicalProcess granulocyte-macrophage colony-stimulating factor signaling pathway The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors. go.json CSF2 signaling pathway|GM-CSF receptor signaling pathway|GM-CSF signaling pathway|granulocyte-macrophage colony-stimulating factor receptor signaling pathway|granulocyte-macrophage colony-stimulating factor signalling pathway http://purl.obolibrary.org/obo/GO_0038157 GO:0038156 biolink:BiologicalProcess interleukin-3-mediated signaling pathway The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-3-mediated signaling pathway|interleukin-3-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038156 GO:0038148 biolink:BiologicalProcess chemokine (C-C motif) ligand 2 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CCL2 signaling pathway http://purl.obolibrary.org/obo/GO_0038148 GO:0038147 biolink:MolecularActivity C-X-C motif chemokine 12 receptor activity Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CXCL12 receptor activity|CXCR4|CXCR7|SDF-1 receptor activity|stromal cell-derived factor-1 receptor activity http://purl.obolibrary.org/obo/GO_0038147 GO:0038149 biolink:MolecularActivity C-C motif chemokine 2 receptor activity Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CCL2 receptor activity http://purl.obolibrary.org/obo/GO_0038149 GO:0038140 biolink:CellularComponent ERBB4-ERBB3 complex A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission. go.json ERBB3-ERBB4 complex|ERBB4:ERBB3 heterodimer http://purl.obolibrary.org/obo/GO_0038140 GO:0038142 biolink:CellularComponent EGFR:ERBB2 complex A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. go.json EGF:EGFR:ERBB2 complex|EGFR:ERBB2 heterodimer http://purl.obolibrary.org/obo/GO_0038142 GO:0038141 biolink:CellularComponent ERBB4-ERBB4 complex A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4). go.json ERBB4 homodimer http://purl.obolibrary.org/obo/GO_0038141 GO:0038144 biolink:CellularComponent ERBB4:ERBB2 complex A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. go.json ERBB4:ERBB2 heterodimer|NRGs/EGFLs:ERBB4:ERBB2 http://purl.obolibrary.org/obo/GO_0038144 GO:0038143 biolink:CellularComponent ERBB3:ERBB2 complex A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. go.json EGFR:ERBB2 heterodimer|NRG1/2:ERBB3:ERBB2 http://purl.obolibrary.org/obo/GO_0038143 GO:0038146 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 12 signaling pathway The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CXCL12 signaling pathway|CXCL12-activated CXCR7 signaling pathway|SDF1 signaling pathway|stromal cell-derived factor-1 signaling pathway http://purl.obolibrary.org/obo/GO_0038146 GO:0038145 biolink:BiologicalProcess macrophage colony-stimulating factor signaling pathway The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json M-CSF signaling pathway|macrophage colony-stimulating factor signalling pathway http://purl.obolibrary.org/obo/GO_0038145 GO:0004800 biolink:MolecularActivity thyroxine 5'-deiodinase activity Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. EC:1.21.99.4|MetaCyc:THYROXINE-DEIODINASE-RXN|RHEA:19745|Reactome:R-HSA-209772|Reactome:R-HSA-350869 go.json L-thyroxine iodohydrolase (reducing) activity|acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)|diiodothyronine 5'-deiodinase activity|iodothyronine 5'-deiodinase activity|iodothyronine outer ring monodeiodinase activity|outer ring-deiodinating pathway|thyroxine 5' deiodinase activity|thyroxine deiodinase activity|type I iodothyronine deiodinase activity|type II iodothyronine deiodinase activity http://purl.obolibrary.org/obo/GO_0004800 GO:0004802 biolink:MolecularActivity transketolase activity Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. EC:2.2.1.1|MetaCyc:1TRANSKETO-RXN|RHEA:10508|Reactome:R-HSA-163741|Reactome:R-HSA-163751|Reactome:R-HSA-71324|Reactome:R-HSA-71335 go.json fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity|glycoaldehyde transferase activity|glycolaldehydetransferase activity|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity http://purl.obolibrary.org/obo/GO_0004802 GO:0004801 biolink:MolecularActivity transaldolase activity Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. EC:2.2.1.2|MetaCyc:TRANSALDOL-RXN|RHEA:17053|Reactome:R-HSA-163764|Reactome:R-HSA-5659989|Reactome:R-HSA-5659998|Reactome:R-HSA-71334 go.json dihydroxyacetone transferase activity|dihydroxyacetonetransferase activity|glycerone transferase activity|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity http://purl.obolibrary.org/obo/GO_0004801 GO:0004808 biolink:MolecularActivity tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate. EC:2.1.1.61|KEGG_REACTION:R00601|MetaCyc:RXN0-5144|RHEA:19569 go.json tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity http://purl.obolibrary.org/obo/GO_0004808 GO:0004807 biolink:MolecularActivity triose-phosphate isomerase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. EC:5.3.1.1|KEGG_REACTION:R01015|MetaCyc:TRIOSEPISOMERIZATION-RXN|RHEA:18585|Reactome:R-HSA-70454|Reactome:R-HSA-70481 go.json D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity|D-glyceraldehyde-3-phosphate ketol-isomerase activity|phosphotriose isomerase activity|triose phosphate mutase activity|triose phosphoisomerase activity|triosephosphate isomerase activity|triosephosphate mutase activity http://purl.obolibrary.org/obo/GO_0004807 GO:0004809 biolink:MolecularActivity tRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. Reactome:R-HSA-6782416|Reactome:R-HSA-6786501 go.json N(2),N(2)-dimethylguanine tRNA methyltransferase activity|N2,N2-dimethylguanine tRNA methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity|guanine-N2-methylase activity|tRNA 2,2-dimethylguanosine-26 methyltransferase activity|tRNA(guanine-26,N(2)-N(2)) methyltransferase activity|tRNA(guanine-26,N2-N2) methyltransferase activity|tRNA(m(2,2)G26)dimethyltransferase activity|transfer RNA guanine 2-methyltransferase activity|transfer ribonucleate guanine 2-methyltransferase activity|transfer ribonucleate guanine N2-methyltransferase activity http://purl.obolibrary.org/obo/GO_0004809 GO:0004804 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004804 GO:0004803 biolink:MolecularActivity transposase activity Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. go.json P-element encoded transposase activity http://purl.obolibrary.org/obo/GO_0004803 goslim_metagenomics|goslim_pir GO:0004806 biolink:MolecularActivity triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. EC:3.1.1.3|MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN|RHEA:12044|Reactome:R-HSA-1482777|Reactome:R-HSA-163551|Reactome:R-HSA-5694109|Reactome:R-HSA-8848338|Reactome:R-HSA-8848339 go.json GA 56|GEH|PPL|TAG activity|amano AP|amano B|amano CE|amano CES|amano P|amno N-AP|butyrinase activity|cacordase activity|capalase L|glycerol ester hydrolase activity|glycerol-ester hydrolase activity|heparin releasable hepatic lipase|hepatic lipase|hepatic monoacylglycerol acyltransferase|lipazin|liver lipase|meito MY 30|meito sangyo OF lipase|post-heparin plasma protamine-resistant lipase|salt-resistant post-heparin lipase|steapsin|takedo 1969-4-9|triacetinase activity|triacylglycerol acylhydrolase activity|triacylglycerol ester hydrolase activity|triacylglycerol lipase activity|tributyrase activity|tributyrin esterase activity|tributyrinase activity|triglyceridase activity|triglyceride hydrolase activity|triolein hydrolase activity|tween hydrolase activity|tween-hydrolyzing esterase activity|tweenase activity|tweenesterase activity http://purl.obolibrary.org/obo/GO_0004806 goslim_chembl GO:0004805 biolink:MolecularActivity trehalose-phosphatase activity Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate. EC:3.1.3.12|MetaCyc:TREHALOSEPHOSPHA-RXN|RHEA:23420 go.json trehalose 6-phosphatase activity|trehalose 6-phosphate phosphatase activity|trehalose phosphatase activity|trehalose-6-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0004805 GO:0004811 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004811 GO:0004810 biolink:MolecularActivity CCA tRNA nucleotidyltransferase activity Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. EC:2.7.7.72|MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN|RHEA:14433 go.json ATP(CTP)-tRNA nucleotidyltransferase|ATP(CTP):tRNA nucleotidyltransferase activity|CCA-adding enzyme activity|CTP(ATP):tRNA nucleotidyltransferase|CTP:tRNA cytidylyltransferase activity|ribonucleic cytidylic cytidylic adenylic pyrophosphorylase|ribonucleic cytidylyltransferase|tRNA CCA-diphosphorylase activity|tRNA adenylyl(cytidylyl)transferase|tRNA cytidylyltransferase activity|tRNA-nucleotidyltransferase activity|transfer RNA adenylyltransferase|transfer ribonucleate adenyltransferase activity|transfer ribonucleate adenylyltransferase|transfer ribonucleate nucleotidyltransferase|transfer ribonucleic acid nucleotidyl transferase|transfer ribonucleic adenylyl (cytidylyl) transferase|transfer ribonucleic-terminal trinucleotide nucleotidyltransferase|transfer-RNA nucleotidyltransferase http://purl.obolibrary.org/obo/GO_0004810 GO:0004813 biolink:MolecularActivity alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). EC:6.1.1.7|MetaCyc:ALANINE--TRNA-LIGASE-RXN|RHEA:12540|Reactome:R-HSA-379864|Reactome:R-HSA-380177 go.json Ala-tRNA synthetase activity|AlaRS|L-alanine:tRNAAla ligase (AMP-forming)|alanine tRNA synthetase activity|alanine transfer RNA synthetase activity|alanine translase activity|alanine-transfer RNA ligase activity|alanyl-tRNA synthetase activity|alanyl-transfer RNA synthetase activity|alanyl-transfer ribonucleate synthase activity|alanyl-transfer ribonucleate synthetase activity|alanyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004813 GO:0004812 biolink:MolecularActivity aminoacyl-tRNA ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. EC:6.1.1.- go.json aminoacyl-tRNA synthetase activity|aminoacyl-tRNA synthetase auxiliary protein activity|ligase activity, forming aminoacyl-tRNA and related compounds http://purl.obolibrary.org/obo/GO_0004812 GO:0004819 biolink:MolecularActivity glutamine-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). EC:6.1.1.18|MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN|RHEA:20121|Reactome:R-HSA-379982|Reactome:R-HSA-380241 go.json GlnRS|L-glutamine:tRNAGln ligase (AMP-forming)|glutamine translase activity|glutamine-tRNA synthetase activity|glutaminyl ribonucleic acid|glutaminyl-tRNA synthetase activity|glutaminyl-transfer RNA synthetase activity|glutaminyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_0004819 GO:0004818 biolink:MolecularActivity glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). EC:6.1.1.17|MetaCyc:GLURS-RXN|RHEA:23540|Reactome:R-HSA-379861|Reactome:R-HSA-380216 go.json L-glutamate:tRNAGlu ligase (AMP-forming) activity|glutamate-tRNA synthetase activity|glutamic acid translase activity|glutamyl-tRNA synthetase activity|glutamyl-transfer RNA synthetase activity|glutamyl-transfer ribonucleate synthetase activity|glutamyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004818 GO:0004815 biolink:MolecularActivity aspartate-tRNA ligase activity Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). EC:6.1.1.12|MetaCyc:ASPARTATE--TRNA-LIGASE-RXN|RHEA:19649|Reactome:R-HSA-379867|Reactome:R-HSA-380229 go.json L-aspartate:tRNAAsp ligase (AMP-forming)|aspartic acid translase activity|aspartyl ribonucleate synthetase activity|aspartyl ribonucleic synthetase activity|aspartyl-tRNA synthetase activity|aspartyl-transfer RNA synthetase activity|aspartyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004815 GO:0004814 biolink:MolecularActivity arginine-tRNA ligase activity Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). EC:6.1.1.19|MetaCyc:ARGININE--TRNA-LIGASE-RXN|RHEA:20301|Reactome:R-HSA-379993|Reactome:R-HSA-380224 go.json L-arginine:tRNAArg ligase (AMP-forming)|arginine translase activity|arginine-tRNA synthetase activity|arginyl transfer ribonucleic acid synthetase activity|arginyl-tRNA synthetase activity|arginyl-transfer RNA synthetase activity|arginyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_0004814 GO:0004817 biolink:MolecularActivity cysteine-tRNA ligase activity Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). EC:6.1.1.16|MetaCyc:CYSTEINE--TRNA-LIGASE-RXN|RHEA:17773|Reactome:R-HSA-379887|Reactome:R-HSA-380158 go.json L-cysteine:tRNACys ligase (AMP-forming)|cysteine translase activity|cysteinyl-tRNA synthetase activity|cysteinyl-transfer ribonucleate synthetase activity|cysteinyl-transferRNA synthetase activity http://purl.obolibrary.org/obo/GO_0004817 GO:0004816 biolink:MolecularActivity asparagine-tRNA ligase activity Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+. EC:6.1.1.22|KEGG_REACTION:R03648|MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN|RHEA:11180|Reactome:R-HSA-379996|Reactome:R-HSA-380227 go.json L-asparagine:tRNAAsn ligase (AMP-forming)|asparagine translase activity|asparaginyl transfer RNA synthetase activity|asparaginyl transfer ribonucleic acid synthetase activity|asparaginyl-tRNA synthetase activity|asparaginyl-transfer ribonucleate synthetase activity|asparagyl-transfer RNA synthetase activity http://purl.obolibrary.org/obo/GO_0004816 GO:0004767 biolink:MolecularActivity sphingomyelin phosphodiesterase activity Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+. EC:3.1.4.12|KEGG_REACTION:R02541|MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN|RHEA:19253|Reactome:R-HSA-1605797|Reactome:R-HSA-1606273|Reactome:R-HSA-1606288|Reactome:R-HSA-1640164|Reactome:R-HSA-193706 go.json sphingomyelin cholinephosphohydrolase activity|sphingomyelinase activity http://purl.obolibrary.org/obo/GO_0004767 goslim_chembl GO:0004766 biolink:MolecularActivity spermidine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. EC:2.5.1.16|MetaCyc:SPERMIDINESYN-RXN|RHEA:12721|Reactome:R-HSA-351215 go.json S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity|SpeE|aminopropyltransferase activity|putrescine aminopropyltransferase activity|spermidine synthetase activity http://purl.obolibrary.org/obo/GO_0004766 GO:0004769 biolink:MolecularActivity steroid delta-isomerase activity Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. EC:5.3.3.1|MetaCyc:STEROID-DELTA-ISOMERASE-RXN|RHEA:14709|Reactome:R-HSA-193052|Reactome:R-HSA-193073|Reactome:R-HSA-193961|Reactome:R-HSA-195690|Reactome:R-HSA-6807052 go.json 3-oxosteroid delta5-delta4-isomerase activity|3-oxosteroid isomerase activity|delta(5)-3-keto steroid isomerase activity|delta(5)-3-ketosteroid isomerase activity|delta(5)-3-oxosteroid isomerase activity|delta(5)-steroid isomerase activity|delta5(or delta4)-3-keto steroid isomerase activity|delta5-3-keto steroid isomerase activity|delta5-3-ketosteroid isomerase activity|delta5-3-oxosteroid isomerase activity|delta5-ketosteroid isomerase activity|delta5-steroid isomerase activity|hydroxysteroid isomerase activity|steroid D-isomerase activity|steroid isomerase activity http://purl.obolibrary.org/obo/GO_0004769 GO:0004768 biolink:MolecularActivity stearoyl-CoA 9-desaturase activity Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. EC:1.14.19.1|MetaCyc:1.14.19.1-RXN|RHEA:19721|Reactome:R-HSA-5690565|Reactome:R-HSA-8847579 go.json acyl-CoA desaturase|delta(9)-desaturase activity|delta9-desaturase|fatty acid desaturase|stearoyl-CoA desaturase activity http://purl.obolibrary.org/obo/GO_0004768 GO:0004763 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004763 GO:0004762 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004762 GO:0004765 biolink:MolecularActivity shikimate kinase activity Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+. EC:2.7.1.71|KEGG_REACTION:R02412|MetaCyc:SHIKIMATE-KINASE-RXN|RHEA:13121 go.json ATP:shikimate 3-phosphotransferase activity|shikimate kinase (phosphorylating)|shikimate kinase II http://purl.obolibrary.org/obo/GO_0004765 GO:0004764 biolink:MolecularActivity shikimate 3-dehydrogenase (NADP+) activity Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. EC:1.1.1.25|EC:1.1.1.282|KEGG_REACTION:R06847|MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN|RHEA:17737 go.json 5-dehydroshikimate reductase activity|5-dehydroshikimic reductase activity|DHS reductase activity|dehydroshikimic reductase activity|shikimate oxidoreductase activity|shikimate:NADP(+) 5-oxidoreductase activity|shikimate:NADP(+) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004764 GO:0004761 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004761 GO:0004760 biolink:MolecularActivity serine-pyruvate transaminase activity Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. EC:2.6.1.51|KEGG_REACTION:R00585|MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN|RHEA:22852 go.json L-serine:pyruvate aminotransferase activity|SPT|hydroxypyruvate:L-alanine transaminase activity|serine--pyruvate aminotransferase activity|serine-pyruvate aminotransferase activity|serine-pyruvate aminotransferase, type 1|serine-pyruvate aminotransferase, type 2A|serine-pyruvate aminotransferase, type 2B http://purl.obolibrary.org/obo/GO_0004760 GO:0004778 biolink:MolecularActivity succinyl-CoA hydrolase activity Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate. EC:3.1.2.3|KEGG_REACTION:R00407|MetaCyc:SUCCINYL-COA-HYDROLASE-RXN|RHEA:11516 go.json succinyl coenzyme A deacylase activity|succinyl coenzyme A hydrolase activity|succinyl-CoA acylase activity http://purl.obolibrary.org/obo/GO_0004778 GO:0004777 biolink:MolecularActivity succinate-semialdehyde dehydrogenase (NAD+) activity Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. EC:1.2.1.24|MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN|RHEA:13217|Reactome:R-HSA-888548 go.json succinate semialdehyde dehydrogenase activity|succinate semialdehyde:NAD+ oxidoreductase activity|succinate-semialdehyde dehydrogenase activity|succinate-semialdehyde:NAD+ oxidoreductase activity|succinic semialdehyde dehydrogenase activity|succinyl semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004777 GO:0004779 biolink:MolecularActivity sulfate adenylyltransferase activity Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate. go.json sulphate adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0004779 GO:0004774 biolink:MolecularActivity succinate-CoA ligase activity Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. go.json http://purl.obolibrary.org/obo/GO_0004774 GO:0004773 biolink:MolecularActivity steryl-sulfatase activity Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. EC:3.1.6.2|MetaCyc:STERYL-SULFATASE-RXN|RHEA:19873|Reactome:R-HSA-1606839 go.json 3-beta-hydroxysteroid sulfate sulfatase activity|arylsulfatase C activity|dehydroepiandrosterone sulfatase activity|dehydroepiandrosterone sulfate sulfatase activity|phenolic steroid sulfatase activity|pregnenolone sulfatase activity|steroid 3-sulfatase activity|steroid sulfatase activity|steroid sulfate sulfohydrolase activity|sterol sulfatase activity|steryl-sulfate sulfohydrolase activity|steryl-sulphatase activity http://purl.obolibrary.org/obo/GO_0004773 GO:0004776 biolink:MolecularActivity succinate-CoA ligase (GDP-forming) activity Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. EC:6.2.1.4|KEGG_REACTION:R00432|MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN|RHEA:22120|Reactome:R-HSA-71775 go.json succinate:CoA ligase (GDP-forming) activity|succinyl CoA synthetase activity|succinyl coenzyme A synthetase|succinyl coenzyme A synthetase (GDP-forming) activity|succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity|succinyl-CoA synthetase (GDP-forming) activity http://purl.obolibrary.org/obo/GO_0004776 GO:0004775 biolink:MolecularActivity succinate-CoA ligase (ADP-forming) activity Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. EC:6.2.1.5|KEGG_REACTION:R00405|MetaCyc:SUCCCOASYN-RXN|RHEA:17661|Reactome:R-HSA-70997 go.json succinate thiokinase activity|succinic thiokinase|succinyl coenzyme A synthetase|succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity|succinyl-CoA synthetase (ADP-forming) activity|succinyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0004775 GO:0004770 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004770 GO:0004772 biolink:MolecularActivity sterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. go.json sterol-ester synthase activity|sterol-ester synthetase activity http://purl.obolibrary.org/obo/GO_0004772 GO:0004771 biolink:MolecularActivity sterol esterase activity Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. EC:3.1.1.13|MetaCyc:STEROL-ESTERASE-RXN|RHEA:10100|Reactome:R-HSA-192417|Reactome:R-HSA-6813720|Reactome:R-HSA-8865667 go.json acylcholesterol lipase activity|cholesterase activity|cholesterol ester hydrolase activity|cholesterol ester synthase activity|cholesterol esterase activity|cholesteryl ester hydrolase activity|cholesteryl ester synthase activity|cholesteryl esterase activity|sterol ester hydrolase activity|steryl-ester acylhydrolase activity|triterpenol esterase activity http://purl.obolibrary.org/obo/GO_0004771 goslim_chembl GO:0004745 biolink:MolecularActivity NAD-retinol dehydrogenase activity Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. EC:1.1.1.105|MetaCyc:RETINOL-DEHYDROGENASE-RXN|RHEA:21284|Reactome:R-HSA-2454081|Reactome:R-HSA-2466832|Reactome:R-HSA-5362518|Reactome:R-HSA-5362564|Reactome:R-HSA-5362721 go.json all-trans retinol dehydrogenase activity|retinal reductase activity|retinene reductase activity|retinol (vitamin A1) dehydrogenase activity|retinol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004745 GO:0004744 biolink:MolecularActivity obsolete retinal isomerase activity OBSOLETE. Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. KEGG_REACTION:R02126|MetaCyc:RETINAL-ISOMERASE-RXN go.json all-trans-retinal 11-cis-trans-isomerase activity|retinene isomerase activity|retinoid isomerase activity True http://purl.obolibrary.org/obo/GO_0004744 GO:0004747 biolink:MolecularActivity ribokinase activity Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. EC:2.7.1.15|MetaCyc:RIBOKIN-RXN|RHEA:13697|Reactome:R-HSA-8955844 go.json ATP:D-ribose 5-phosphotransferase activity|D-ribokinase activity|deoxyribokinase activity|ribokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004747 GO:0004746 biolink:MolecularActivity riboflavin synthase activity Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin. EC:2.5.1.9|KEGG_REACTION:R00066|MetaCyc:RIBOFLAVIN-SYN-RXN|RHEA:20772 go.json 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity|heavy riboflavin synthase|light riboflavin synthase|lumazine synthase activity|riboflavin synthetase activity|riboflavine synthase activity|riboflavine synthetase activity|vitamin B2 synthase activity http://purl.obolibrary.org/obo/GO_0004746 GO:0004741 biolink:MolecularActivity [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate. EC:3.1.3.43|MetaCyc:3.1.3.43-RXN|RHEA:12669|Reactome:R-HSA-204169 go.json [pyruvate dehydrogenase (lipoamide)] phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity|pyruvate dehydrogenase (lipoamide) phosphatase activity http://purl.obolibrary.org/obo/GO_0004741 GO:0004740 biolink:MolecularActivity pyruvate dehydrogenase (acetyl-transferring) kinase activity Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. EC:2.7.11.2|MetaCyc:2.7.11.2-RXN|RHEA:23052|Reactome:R-HSA-203946 go.json PDH kinase activity|PDHK|PDK|pyruvate dehydrogenase kinase (phosphorylating) activity|pyruvate dehydrogenase kinase activity http://purl.obolibrary.org/obo/GO_0004740 GO:0004743 biolink:MolecularActivity pyruvate kinase activity Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate. EC:2.7.1.40|MetaCyc:PEPDEPHOS-RXN|RHEA:18159|Reactome:R-HSA-71670 go.json ATP:pyruvate 2-O-phosphotransferase activity|phosphoenol transphosphorylase activity|phosphoenolpyruvate kinase activity http://purl.obolibrary.org/obo/GO_0004743 GO:0004742 biolink:MolecularActivity dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA. EC:2.3.1.12|RHEA:17017 go.json acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity|acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity|acetyl-CoA:dihydrolipoamide S-acetyltransferase activity|dihydrolipoamide S-acetyltransferase activity|dihydrolipoamide S-acyltransferase activity|dihydrolipoate acetyltransferase activity|dihydrolipoic transacetylase activity|dihydrolipoyl acetyltransferase activity|enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity|lipoate acetyltransferase activity|lipoate transacetylase activity|lipoic acetyltransferase activity|lipoic acid acetyltransferase activity|lipoic transacetylase activity|lipoylacetyltransferase activity|thioltransacetylase A activity|transacetylase X activity http://purl.obolibrary.org/obo/GO_0004742 GO:0004749 biolink:MolecularActivity ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. EC:2.7.6.1|KEGG_REACTION:R01049|MetaCyc:PRPPSYN-RXN|MetaCyc:PWY0-662|RHEA:15609|Reactome:R-HSA-111215|Reactome:R-HSA-73580 go.json 5-phosphoribose pyrophosphorylase activity|5-phosphoribosyl-1-pyrophosphate synthetase activity|5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity|ATP:D-ribose-5-phosphate diphosphotransferase activity|PP-ribose P synthetase activity|PPRibP synthetase activity|PRPP synthetase activity|phosphoribosyl diphosphate synthetase activity|phosphoribosyl pyrophosphate synthetase activity|phosphoribosyl-diphosphate synthetase activity|phosphoribosylpyrophosphate synthase activity|phosphoribosylpyrophosphate synthetase activity|pyrophosphoribosylphosphate synthetase activity|ribophosphate pyrophosphokinase activity|ribose-5-phosphate pyrophosphokinase activity|ribose-phosphate diphosphokinase activity|ribose-phosphate pyrophosphokinase activity http://purl.obolibrary.org/obo/GO_0004749 GO:0004748 biolink:MolecularActivity ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. EC:1.17.4.1|MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN|RHEA:23252|Reactome:R-HSA-111751|Reactome:R-HSA-111804 go.json 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity|2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004748 GO:0004756 biolink:MolecularActivity selenide, water dikinase activity Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate. EC:2.7.9.3|KEGG_REACTION:R03595|MetaCyc:2.7.9.3-RXN|RHEA:18737|Reactome:R-HSA-8959510|UM-BBD_reactionID:r0833 go.json ATP:selenide, water phosphotransferase activity|selenide,water dikinase activity|selenium donor protein activity|selenophosphate synthase activity|selenophosphate synthetase activity http://purl.obolibrary.org/obo/GO_0004756 GO:0004755 biolink:MolecularActivity saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH. EC:1.5.1.10|KEGG_REACTION:R02315|MetaCyc:RXN3O-127|RHEA:10020 go.json 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)|N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)|aminoadipate semialdehyde-glutamate reductase activity|aminoadipic semialdehyde-glutamate reductase activity|aminoadipic semialdehyde-glutamic reductase activity|epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)|saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity|saccharopine reductase activity http://purl.obolibrary.org/obo/GO_0004755 GO:0004758 biolink:MolecularActivity serine C-palmitoyltransferase activity Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA. EC:2.3.1.50|KEGG_REACTION:R01281|MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN|RHEA:14761|Reactome:R-HSA-428127 go.json 3-oxosphinganine synthetase activity|SPT|serine palmitoyltransferase http://purl.obolibrary.org/obo/GO_0004758 GO:0004757 biolink:MolecularActivity sepiapterin reductase activity Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. EC:1.1.1.153|MetaCyc:SEPIAPTERIN-REDUCTASE-RXN|RHEA:18953|Reactome:R-HSA-1475414|Reactome:R-HSA-1497869 go.json 7,8-dihydrobiopterin:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004757 GO:0004752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004752 GO:0004751 biolink:MolecularActivity ribose-5-phosphate isomerase activity Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. EC:5.3.1.6|KEGG_REACTION:R01056|MetaCyc:RIB5PISOM-RXN|RHEA:14657|Reactome:R-HSA-177784|Reactome:R-HSA-5660013|Reactome:R-HSA-5660015|Reactome:R-HSA-71306 go.json 5-phosphoribose isomerase activity|D-ribose 5-phosphate isomerase activity|D-ribose-5-phosphate aldose-ketose-isomerase activity|D-ribose-5-phosphate ketol-isomerase activity|pentose phosphate isomerase (PPI)|phosphopentoseisomerase activity|phosphopentosisomerase activity|phosphoriboisomerase activity|ribose 5-phosphate epimerase activity|ribose phosphate isomerase activity http://purl.obolibrary.org/obo/GO_0004751 GO:0004754 biolink:MolecularActivity saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH. EC:1.5.1.7|KEGG_REACTION:R00715|MetaCyc:1.5.1.7-RXN|RHEA:12440 go.json 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)|N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)|N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)|dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)|epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming) http://purl.obolibrary.org/obo/GO_0004754 GO:0004753 biolink:MolecularActivity saccharopine dehydrogenase activity Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. go.json lysine-2-oxoglutarate reductase activity|lysine-ketoglutarate reductase activity http://purl.obolibrary.org/obo/GO_0004753 GO:0004750 biolink:MolecularActivity D-ribulose-phosphate 3-epimerase activity Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. EC:5.1.3.1|KEGG_REACTION:R01529|MetaCyc:RIBULP3EPIM-RXN|RHEA:13677|Reactome:R-HSA-199803|Reactome:R-HSA-71303 go.json D-ribulose 5-phosphate epimerase activity|D-ribulose phosphate-3-epimerase activity|D-ribulose-5-P 3-epimerase activity|D-ribulose-5-phosphate 3-epimerase activity|D-ribulose-5-phosphate epimerase activity|D-xylulose-5-phosphate 3-epimerase activity|erythrose-4-phosphate epimerase activity|erythrose-4-phosphate isomerase activity|pentose phosphate epimerase (PPE)|pentose-5-phosphate 3-epimerase activity|phosphoketopentose 3-epimerase activity|phosphoketopentose epimerase activity|phosphoribulose epimerase activity|ribulose 5-phosphate 3-epimerase activity|ribulose-phosphate 3-epimerase activity|xylulose phosphate 3-epimerase activity http://purl.obolibrary.org/obo/GO_0004750 GO:0004759 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004759 GO:0004723 biolink:MolecularActivity calcium-dependent protein serine/threonine phosphatase activity Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. Reactome:R-HSA-2025882 go.json calcineurin|calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity http://purl.obolibrary.org/obo/GO_0004723 GO:0004722 biolink:MolecularActivity protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. EC:3.1.3.16|MetaCyc:3.1.3.16-RXN|Reactome:R-HSA-1295632|Reactome:R-HSA-163568|Reactome:R-HSA-163689|Reactome:R-HSA-163750|Reactome:R-HSA-1638821|Reactome:R-HSA-199425|Reactome:R-HSA-199959|Reactome:R-HSA-201787|Reactome:R-HSA-201790|Reactome:R-HSA-209055|Reactome:R-HSA-2187401|Reactome:R-HSA-2995388|Reactome:R-HSA-3002811|Reactome:R-HSA-3601585|Reactome:R-HSA-380949|Reactome:R-HSA-4088141|Reactome:R-HSA-429730|Reactome:R-HSA-4419948|Reactome:R-HSA-5672957|Reactome:R-HSA-5672961|Reactome:R-HSA-5675431|Reactome:R-HSA-5675433|Reactome:R-HSA-5679206|Reactome:R-HSA-5683405|Reactome:R-HSA-5687758|Reactome:R-HSA-5692754|Reactome:R-HSA-5693153|Reactome:R-HSA-5694421|Reactome:R-HSA-6792863|Reactome:R-HSA-6811504|Reactome:R-HSA-74948|Reactome:R-HSA-8948139|Reactome:R-HSA-9619430|Reactome:R-HSA-9619449|Reactome:R-HSA-9619467|Reactome:R-HSA-9658445|Reactome:R-HSA-9660536|Reactome:R-HSA-9660538|Reactome:R-HSA-9686524 go.json magnesium-dependent protein serine/threonine phosphatase activity|phosphatase I|phosphatase II|phosphatase III|protein phosphatase type 1 activity|protein phosphatase type 2A activity|protein phosphatase type 2B activity|protein phosphatase type 2C activity|protein phosphatase-1|protein phosphatase-2A|protein phosphatase-2B|protein phosphatase-2C|protein serine phosphatase activity|protein threonine phosphatase activity|serine/threonine specific protein phosphatase activity http://purl.obolibrary.org/obo/GO_0004722 GO:0004725 biolink:MolecularActivity protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. EC:3.1.3.48|MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN|RHEA:10684|Reactome:R-HSA-1169188|Reactome:R-HSA-1169192|Reactome:R-HSA-1169210|Reactome:R-HSA-1549564|Reactome:R-HSA-202214|Reactome:R-HSA-203797|Reactome:R-HSA-377643|Reactome:R-HSA-389758|Reactome:R-HSA-391868|Reactome:R-HSA-445089|Reactome:R-HSA-5683967|Reactome:R-HSA-6807008|Reactome:R-HSA-6807027|Reactome:R-HSA-74733|Reactome:R-HSA-74747|Reactome:R-HSA-74748|Reactome:R-HSA-877308|Reactome:R-HSA-8849435|Reactome:R-HSA-8852200|Reactome:R-HSA-8855381|Reactome:R-HSA-8863804|Reactome:R-HSA-8864029|Reactome:R-HSA-8864036|Reactome:R-HSA-8864125|Reactome:R-HSA-8867047|Reactome:R-HSA-8867658|Reactome:R-HSA-8937767|Reactome:R-HSA-914036|Reactome:R-HSA-9603719|Reactome:R-HSA-9635461|Reactome:R-HSA-9636439|Reactome:R-HSA-9674816|Reactome:R-HSA-9698408|Reactome:R-HSA-9700200|Reactome:R-HSA-9701507|Reactome:R-HSA-997309|Reactome:R-HSA-997311|Reactome:R-HSA-997314|Reactome:R-HSA-997326 go.json PPT-phosphatase activity|PTP-phosphatase activity|PTPase activity|[phosphotyrosine]protein phosphatase activity|phosphoprotein phosphatase (phosphotyrosine) activity|phosphotyrosine histone phosphatase activity|phosphotyrosine phosphatase activity|phosphotyrosine protein phosphatase activity|phosphotyrosylprotein phosphatase activity|protein phosphotyrosine phosphatase activity|protein-tyrosine-phosphatase activity|protein-tyrosine-phosphate phosphohydrolase activity|tyrosine O-phosphate phosphatase activity|tyrosylprotein phosphatase activity http://purl.obolibrary.org/obo/GO_0004725 GO:0004724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004724 GO:0004721 biolink:MolecularActivity phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. Reactome:R-HSA-112383|Reactome:R-HSA-113503|Reactome:R-HSA-1363274|Reactome:R-HSA-1363276|Reactome:R-HSA-167072|Reactome:R-HSA-170153|Reactome:R-HSA-170158|Reactome:R-HSA-170161|Reactome:R-HSA-174110|Reactome:R-HSA-174124|Reactome:R-HSA-178178|Reactome:R-HSA-2529015|Reactome:R-HSA-69199|Reactome:R-HSA-9636684 go.json phosphoprotein phosphohydrolase activity|protein phosphatase activity|protein phosphatase-1 activity|protein phosphatase-2A activity|protein phosphatase-2B activity|protein phosphatase-2C activity http://purl.obolibrary.org/obo/GO_0004721 GO:0004720 biolink:MolecularActivity protein-lysine 6-oxidase activity Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. EC:1.4.3.13|MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN|RHEA:24544|Reactome:R-HSA-2002466|Reactome:R-HSA-2129375|Reactome:R-HSA-2395340 go.json lysyl oxidase activity|protein-L-lysine:oxygen 6-oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0004720 GO:0004727 biolink:MolecularActivity prenylated protein tyrosine phosphatase activity Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. go.json http://purl.obolibrary.org/obo/GO_0004727 GO:0004726 biolink:MolecularActivity non-membrane spanning protein tyrosine phosphatase activity Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. Reactome:R-HSA-177923|Reactome:R-HSA-177924|Reactome:R-HSA-177926|Reactome:R-HSA-177935|Reactome:R-HSA-9635739 go.json http://purl.obolibrary.org/obo/GO_0004726 GO:0004729 biolink:MolecularActivity oxygen-dependent protoporphyrinogen oxidase activity Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX. EC:1.3.3.4|KEGG_REACTION:R03222|MetaCyc:PROTOPORGENOXI-RXN|RHEA:25576|Reactome:R-HSA-189423 go.json protoporphyrinogen-IX:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004729 GO:0004728 biolink:MolecularActivity obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. go.json receptor signaling protein tyrosine phosphatase activity|receptor signalling protein tyrosine phosphatase activity True http://purl.obolibrary.org/obo/GO_0004728 GO:0004734 biolink:MolecularActivity pyrimidodiazepine synthase activity Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione. EC:1.5.4.1|MetaCyc:1.5.4.1-RXN|RHEA:10720 go.json PDA synthase activity|pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing) http://purl.obolibrary.org/obo/GO_0004734 GO:0004733 biolink:MolecularActivity pyridoxamine phosphate oxidase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide. EC:1.4.3.5|MetaCyc:PMPOXI-RXN|RHEA:15817|Reactome:R-HSA-965019|Reactome:R-HSA-965079 go.json PMP oxidase activity|pyridoxal 5'-phosphate synthase activity|pyridoxamine 5'-phosphate oxidase activity|pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)|pyridoxamine-phosphate oxidase activity|pyridoxaminephosphate oxidase deaminating|pyridoxine (pyridoxamine) 5'-phosphate oxidase activity|pyridoxine (pyridoxamine)phosphate oxidase activity http://purl.obolibrary.org/obo/GO_0004733 GO:0004736 biolink:MolecularActivity pyruvate carboxylase activity Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate. EC:6.4.1.1|KEGG_REACTION:R00344|MetaCyc:PYRUVATE-CARBOXYLASE-RXN|RHEA:20844|Reactome:R-HSA-70501 go.json pyruvate:carbon-dioxide ligase (ADP-forming)|pyruvic carboxylase activity http://purl.obolibrary.org/obo/GO_0004736 GO:0004735 biolink:MolecularActivity pyrroline-5-carboxylate reductase activity Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. EC:1.5.1.2|MetaCyc:PYRROLINECARBREDUCT-RXN|RHEA:14109|Reactome:R-HSA-6783939|Reactome:R-HSA-6783955|Reactome:R-HSA-70664 go.json 1-pyrroline-5-carboxylate reductase activity|L-proline oxidase activity|L-proline-NAD(P)+ 5-oxidoreductase activity|L-proline:NAD(P)+ 5-oxidoreductase activity|NADPH-L-delta1-pyrroline carboxylic acid reductase activity|P5CR activity http://purl.obolibrary.org/obo/GO_0004735 GO:0004730 biolink:MolecularActivity pseudouridylate synthase activity Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate. EC:4.2.1.70|KEGG_REACTION:R01055|MetaCyc:RXN0-5398|RHEA:18337 go.json 5-ribosyluracil 5-phosphate synthetase activity|pseudouridine monophosphate synthase activity|pseudouridine monophosphate synthetase activity|pseudouridine-5'-phosphate glycosidase activity|pseudouridylate synthetase activity|pseudouridylic acid synthetase activity|psiUMP synthetase activity|uracil hydro-lyase (adding D-ribose 5-phosphate)|uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)|uracil hydrolyase activity http://purl.obolibrary.org/obo/GO_0004730 GO:0004732 biolink:MolecularActivity pyridoxal oxidase activity Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide. EC:1.2.3.8|MetaCyc:PYRIDOXAL-OXIDASE-RXN|RHEA:23724 go.json pyridoxal:oxygen 4-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004732 GO:0004731 biolink:MolecularActivity purine-nucleoside phosphorylase activity Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. EC:2.4.2.1|MetaCyc:PNP-RXN|RHEA:19805|Reactome:R-HSA-112033|Reactome:R-HSA-112034|Reactome:R-HSA-74242|Reactome:R-HSA-74249|Reactome:R-HSA-9735775|Reactome:R-HSA-9735789|Reactome:R-HSA-9755044 go.json PNPase activity|PUNPI|PUNPII|inosine phosphorylase activity|inosine-guanosine phosphorylase activity|purine deoxynucleoside phosphorylase activity|purine deoxyribonucleoside phosphorylase activity|purine nucleoside phosphorylase activity|purine ribonucleoside phosphorylase activity|purine-nucleoside:phosphate ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0004731 GO:0004738 biolink:MolecularActivity pyruvate dehydrogenase activity Catalysis of the oxidative decarboxylation of pyruvate. MetaCyc:RXN0-1134|Reactome:R-HSA-71397 go.json pyruvic acid dehydrogenase activity|pyruvic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004738 GO:0004737 biolink:MolecularActivity pyruvate decarboxylase activity Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. EC:4.1.1.1|MetaCyc:PYRUVATE-DECARBOXYLASE-RXN|RHEA:11628 go.json 2-oxo-acid carboxy-lyase (aldehyde-forming)|2-oxo-acid carboxy-lyase activity|alpha-carboxylase activity|alpha-ketoacid carboxylase activity|pyruvic decarboxylase activity http://purl.obolibrary.org/obo/GO_0004737 GO:0004739 biolink:MolecularActivity pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. EC:1.2.4.1|RHEA:19189 go.json MtPDC (mitochondrial pyruvate dehydogenase complex) activity|PDH|pyruvate dehydrogenase (lipoamide) activity|pyruvate dehydrogenase complex activity|pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)|pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity http://purl.obolibrary.org/obo/GO_0004739 GO:0004701 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004701 GO:0004700 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004700 GO:0004703 biolink:MolecularActivity G protein-coupled receptor kinase activity Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. EC:2.7.11.16|RHEA:12008 go.json ATP:G-protein-coupled receptor phosphotransferase activity|G protein coupled receptor phosphorylating protein kinase activity|G-protein coupled receptor kinase activity|G-protein-coupled receptor phosphorylating protein kinase activity|GPCR kinase activity|GPCR phosphorylating protein kinase activity|GPCRK|GRK4|GRK5|GRK6|STK16 http://purl.obolibrary.org/obo/GO_0004703 GO:0004702 biolink:MolecularActivity obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. EC:2.7.11.- go.json receptor signaling protein serine/threonine kinase activity|receptor signalling protein serine/threonine kinase activity True http://purl.obolibrary.org/obo/GO_0004702 GO:0004709 biolink:MolecularActivity MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. EC:2.7.11.25|MetaCyc:2.7.11.25-RXN|Reactome:R-HSA-2730887|Reactome:R-HSA-392530|Reactome:R-HSA-451649|Reactome:R-HSA-727819|Reactome:R-HSA-933530 go.json ATP:protein phosphotransferase (MAPKKKK-activated) activity|MAP3K|MAPK/ERK kinase kinase activity|MAPKKK activity|MEK kinase activity|MEKK|MEKK activity|MEKK1|MEKK2|MEKK3|MLK-like mitogen-activated protein triple kinase activity|MLTK|MLTKa|MLTKb|Mil/Raf|REKS|STK28|cMos|cRaf|mitogen-activated protein kinase kinase kinase activity http://purl.obolibrary.org/obo/GO_0004709 GO:0004708 biolink:MolecularActivity MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. EC:2.7.12.2|MetaCyc:2.7.12.2-RXN|Reactome:R-HSA-1247960|Reactome:R-HSA-3238999|Reactome:R-HSA-448951|Reactome:R-HSA-450333|Reactome:R-HSA-5218804 go.json ATP:protein phosphotransferase (MAPKKK-activated) activity|ERK activator kinase activity|MAP kinase kinase 4 activity|MAP kinase kinase 7 activity|MAP kinase or ERK kinase activity|MAP2K|MAPK activator activity|MAPKK|MAPKK activity|MAPKK1|MEK activity|MEK1|MEK2|MKK|MKK2|MKK4|MKK6|MKK7|STK27|mitogen-activated protein kinase kinase activity http://purl.obolibrary.org/obo/GO_0004708 GO:0004705 biolink:MolecularActivity JUN kinase activity Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. Reactome:R-HSA-168136|Reactome:R-HSA-204949|Reactome:R-HSA-205075|Reactome:R-HSA-205132|Reactome:R-HSA-9673789 go.json JNK|JNK3alpha1|SAPK1|c-Jun N-terminal kinase activity http://purl.obolibrary.org/obo/GO_0004705 GO:0004704 biolink:MolecularActivity obsolete NF-kappaB-inducing kinase activity OBSOLETE. Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). go.json NIK True http://purl.obolibrary.org/obo/GO_0004704 GO:0004707 biolink:MolecularActivity MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. EC:2.7.11.24|KEGG_REACTION:R00162|MetaCyc:2.7.11.24-RXN|Reactome:R-HSA-111898|Reactome:R-HSA-198733|Reactome:R-HSA-445079|Reactome:R-HSA-451366|Reactome:R-HSA-5654560|Reactome:R-HSA-5654562|Reactome:R-HSA-5654565|Reactome:R-HSA-5654566|Reactome:R-HSA-73722|Reactome:R-HSA-9626832 go.json ATP:protein phosphotransferase (MAPKK-activated) activity|ERK|ERK1|ERK2|MAP kinase 1 activity|MAP kinase 2 activity|MAPK|MBP kinase I activity|MBP kinase II activity|SAP kinase activity|SAPK|extracellular signal-regulated kinase activity|mitogen activated kinase activity|mitogen-activated protein kinase activity|myelin basic protein kinase activity|stress-activated kinase activity|stress-activated protein kinase activity http://purl.obolibrary.org/obo/GO_0004707 GO:0004706 biolink:MolecularActivity JUN kinase kinase kinase activity Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). go.json JNK kinase kinase activity|JNKKK http://purl.obolibrary.org/obo/GO_0004706 GO:0004712 biolink:MolecularActivity protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. EC:2.7.12.1|Reactome:R-HSA-5672969|Reactome:R-HSA-5674373|Reactome:R-HSA-6802910|Reactome:R-HSA-6802916|Reactome:R-HSA-6802918|Reactome:R-HSA-6802921|Reactome:R-HSA-6802922|Reactome:R-HSA-6802924|Reactome:R-HSA-6802927|Reactome:R-HSA-6802941|Reactome:R-HSA-9656212 go.json dual-specificity kinase activity|dual-specificity protein kinase|protein threonine/tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004712 GO:0004711 biolink:MolecularActivity ribosomal protein S6 kinase activity Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. go.json http://purl.obolibrary.org/obo/GO_0004711 GO:0004714 biolink:MolecularActivity transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. EC:2.7.10.1|MetaCyc:2.7.10.1-RXN|Reactome:R-HSA-166544|Reactome:R-HSA-167019|Reactome:R-HSA-167683|Reactome:R-HSA-169905|Reactome:R-HSA-177933|Reactome:R-HSA-198295|Reactome:R-HSA-6784324|Reactome:R-HSA-74711|Reactome:R-HSA-74742|Reactome:R-HSA-8852552|Reactome:R-HSA-8853792|Reactome:R-HSA-8950269|Reactome:R-HSA-8950340|Reactome:R-HSA-8950354|Reactome:R-HSA-8950364|Reactome:R-HSA-8950405|Reactome:R-HSA-8950423|Reactome:R-HSA-8950453|Reactome:R-HSA-8950485|Reactome:R-HSA-8950537|Reactome:R-HSA-8950591|Reactome:R-HSA-8950757|Reactome:R-HSA-8982163|Reactome:R-HSA-8983300|Reactome:R-HSA-8983309|Reactome:R-HSA-8983371|Reactome:R-HSA-8983424|Reactome:R-HSA-8986985|Reactome:R-HSA-8986994|Reactome:R-HSA-8986995|Reactome:R-HSA-8987012|Reactome:R-HSA-8987040|Reactome:R-HSA-8987042|Reactome:R-HSA-8987070|Reactome:R-HSA-8987084|Reactome:R-HSA-8987096|Reactome:R-HSA-8987129|Reactome:R-HSA-8987141|Reactome:R-HSA-8987150|Reactome:R-HSA-8987179|Reactome:R-HSA-8987202|Reactome:R-HSA-8987255 go.json receptor protein tyrosine kinase activity|receptor protein-tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004714 GO:0004713 biolink:MolecularActivity protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. RHEA:10596|Reactome:R-HSA-112333|Reactome:R-HSA-114600|Reactome:R-HSA-1168394|Reactome:R-HSA-1169421|Reactome:R-HSA-1225952|Reactome:R-HSA-1225960|Reactome:R-HSA-1247844|Reactome:R-HSA-1248655|Reactome:R-HSA-1248694|Reactome:R-HSA-1250195|Reactome:R-HSA-1250315|Reactome:R-HSA-1250348|Reactome:R-HSA-1251922|Reactome:R-HSA-1295540|Reactome:R-HSA-1295609|Reactome:R-HSA-1307963|Reactome:R-HSA-1433418|Reactome:R-HSA-1433454|Reactome:R-HSA-1433488|Reactome:R-HSA-1433506|Reactome:R-HSA-1433542|Reactome:R-HSA-1470009|Reactome:R-HSA-1472121|Reactome:R-HSA-1524186|Reactome:R-HSA-1671691|Reactome:R-HSA-170070|Reactome:R-HSA-170156|Reactome:R-HSA-170991|Reactome:R-HSA-171011|Reactome:R-HSA-174164|Reactome:R-HSA-177930|Reactome:R-HSA-177934|Reactome:R-HSA-177937|Reactome:R-HSA-182969|Reactome:R-HSA-183058|Reactome:R-HSA-1839065|Reactome:R-HSA-1839067|Reactome:R-HSA-1839098|Reactome:R-HSA-1839110|Reactome:R-HSA-1839112|Reactome:R-HSA-186786|Reactome:R-HSA-1888198|Reactome:R-HSA-190326|Reactome:R-HSA-190385|Reactome:R-HSA-190388|Reactome:R-HSA-190408|Reactome:R-HSA-190413|Reactome:R-HSA-190427|Reactome:R-HSA-190429|Reactome:R-HSA-191062|Reactome:R-HSA-191636|Reactome:R-HSA-1963581|Reactome:R-HSA-1963582|Reactome:R-HSA-1963586|Reactome:R-HSA-1982066|Reactome:R-HSA-2012073|Reactome:R-HSA-2012082|Reactome:R-HSA-2012087|Reactome:R-HSA-201521|Reactome:R-HSA-202165|Reactome:R-HSA-202168|Reactome:R-HSA-202174|Reactome:R-HSA-202216|Reactome:R-HSA-202233|Reactome:R-HSA-202245|Reactome:R-HSA-202248|Reactome:R-HSA-202291|Reactome:R-HSA-202307|Reactome:R-HSA-2023455|Reactome:R-HSA-2023460|Reactome:R-HSA-2029268|Reactome:R-HSA-2029449|Reactome:R-HSA-2029453|Reactome:R-HSA-2029459|Reactome:R-HSA-2029984|Reactome:R-HSA-2029989|Reactome:R-HSA-2033485|Reactome:R-HSA-2033486|Reactome:R-HSA-2033488|Reactome:R-HSA-2033490|Reactome:R-HSA-2038387|Reactome:R-HSA-2038944|Reactome:R-HSA-205289|Reactome:R-HSA-210291|Reactome:R-HSA-210872|Reactome:R-HSA-212710|Reactome:R-HSA-2130194|Reactome:R-HSA-2197698|Reactome:R-HSA-2201322|Reactome:R-HSA-2395412|Reactome:R-HSA-2395439|Reactome:R-HSA-2395801|Reactome:R-HSA-2396594|Reactome:R-HSA-2404193|Reactome:R-HSA-2404199|Reactome:R-HSA-2424484|Reactome:R-HSA-2424486|Reactome:R-HSA-2424487|Reactome:R-HSA-2428926|Reactome:R-HSA-2454208|Reactome:R-HSA-2454239|Reactome:R-HSA-2586553|Reactome:R-HSA-2586555|Reactome:R-HSA-2671742|Reactome:R-HSA-2671829|Reactome:R-HSA-2671850|Reactome:R-HSA-2730833|Reactome:R-HSA-2730843|Reactome:R-HSA-2730851|Reactome:R-HSA-2730858|Reactome:R-HSA-2730860|Reactome:R-HSA-2730862|Reactome:R-HSA-2730882|Reactome:R-HSA-2730884|Reactome:R-HSA-2730886|Reactome:R-HSA-2730888|Reactome:R-HSA-3215391|Reactome:R-HSA-354073|Reactome:R-HSA-354124|Reactome:R-HSA-372693|Reactome:R-HSA-373747|Reactome:R-HSA-373750|Reactome:R-HSA-374701|Reactome:R-HSA-377640|Reactome:R-HSA-380780|Reactome:R-HSA-388831|Reactome:R-HSA-388833|Reactome:R-HSA-389083|Reactome:R-HSA-389086|Reactome:R-HSA-389159|Reactome:R-HSA-389354|Reactome:R-HSA-389762|Reactome:R-HSA-391156|Reactome:R-HSA-391865|Reactome:R-HSA-391866|Reactome:R-HSA-391871|Reactome:R-HSA-3928578|Reactome:R-HSA-3928580|Reactome:R-HSA-3928583|Reactome:R-HSA-3928594|Reactome:R-HSA-3928604|Reactome:R-HSA-3928610|Reactome:R-HSA-3928627|Reactome:R-HSA-3928648|Reactome:R-HSA-399934|Reactome:R-HSA-399946|Reactome:R-HSA-399947|Reactome:R-HSA-4093332|Reactome:R-HSA-418163|Reactome:R-HSA-418859|Reactome:R-HSA-418872|Reactome:R-HSA-419646|Reactome:R-HSA-428888|Reactome:R-HSA-429441|Reactome:R-HSA-429449|Reactome:R-HSA-432129|Reactome:R-HSA-434836|Reactome:R-HSA-4420117|Reactome:R-HSA-4420121|Reactome:R-HSA-4420128|Reactome:R-HSA-4420206|Reactome:R-HSA-443817|Reactome:R-HSA-445076|Reactome:R-HSA-445084|Reactome:R-HSA-445085|Reactome:R-HSA-445091|Reactome:R-HSA-451942|Reactome:R-HSA-452097|Reactome:R-HSA-452100|Reactome:R-HSA-452122|Reactome:R-HSA-508282|Reactome:R-HSA-5218640|Reactome:R-HSA-5218642|Reactome:R-HSA-5218806|Reactome:R-HSA-5218809|Reactome:R-HSA-5218812|Reactome:R-HSA-5218820|Reactome:R-HSA-5218828|Reactome:R-HSA-5218830|Reactome:R-HSA-5218851|Reactome:R-HSA-5357429|Reactome:R-HSA-5607745|Reactome:R-HSA-5607750|Reactome:R-HSA-5621355|Reactome:R-HSA-5621363|Reactome:R-HSA-5621370|Reactome:R-HSA-5624486|Reactome:R-HSA-5637795|Reactome:R-HSA-5637796|Reactome:R-HSA-5654147|Reactome:R-HSA-5654149|Reactome:R-HSA-5654151|Reactome:R-HSA-5654222|Reactome:R-HSA-5654397|Reactome:R-HSA-5654407|Reactome:R-HSA-5654408|Reactome:R-HSA-5654418|Reactome:R-HSA-5654428|Reactome:R-HSA-5654545|Reactome:R-HSA-5654575|Reactome:R-HSA-5654578|Reactome:R-HSA-5654582|Reactome:R-HSA-5654587|Reactome:R-HSA-5654605|Reactome:R-HSA-5654607|Reactome:R-HSA-5654628|Reactome:R-HSA-5654631|Reactome:R-HSA-5654634|Reactome:R-HSA-5654653|Reactome:R-HSA-5654655|Reactome:R-HSA-5655243|Reactome:R-HSA-5655268|Reactome:R-HSA-5655270|Reactome:R-HSA-5655278|Reactome:R-HSA-5655284|Reactome:R-HSA-5655301|Reactome:R-HSA-5655341|Reactome:R-HSA-5683930|Reactome:R-HSA-5686587|Reactome:R-HSA-5690702|Reactome:R-HSA-6784006|Reactome:R-HSA-6784319|Reactome:R-HSA-6790087|Reactome:R-HSA-6806974|Reactome:R-HSA-68954|Reactome:R-HSA-69195|Reactome:R-HSA-873918|Reactome:R-HSA-873919|Reactome:R-HSA-873922|Reactome:R-HSA-873924|Reactome:R-HSA-879907|Reactome:R-HSA-879909|Reactome:R-HSA-879925|Reactome:R-HSA-8847977|Reactome:R-HSA-8848005|Reactome:R-HSA-8848077|Reactome:R-HSA-8848124|Reactome:R-HSA-8848436|Reactome:R-HSA-8848606|Reactome:R-HSA-8848726|Reactome:R-HSA-8848758|Reactome:R-HSA-8848776|Reactome:R-HSA-8848818|Reactome:R-HSA-8848873|Reactome:R-HSA-8848975|Reactome:R-HSA-8849032|Reactome:R-HSA-8849042|Reactome:R-HSA-8849068|Reactome:R-HSA-8849102|Reactome:R-HSA-8849463|Reactome:R-HSA-8851890|Reactome:R-HSA-8851933|Reactome:R-HSA-8853309|Reactome:R-HSA-8853313|Reactome:R-HSA-8853325|Reactome:R-HSA-8855237|Reactome:R-HSA-8857555|Reactome:R-HSA-8857577|Reactome:R-HSA-8857583|Reactome:R-HSA-8857925|Reactome:R-HSA-8867041|Reactome:R-HSA-8874078|Reactome:R-HSA-8874080|Reactome:R-HSA-8874082|Reactome:R-HSA-8875451|Reactome:R-HSA-8875817|Reactome:R-HSA-8876230|Reactome:R-HSA-8876246|Reactome:R-HSA-8876948|Reactome:R-HSA-8937728|Reactome:R-HSA-8937807|Reactome:R-HSA-8937844|Reactome:R-HSA-8942607|Reactome:R-HSA-8948143|Reactome:R-HSA-8956659|Reactome:R-HSA-8964242|Reactome:R-HSA-8964252|Reactome:R-HSA-8983872|Reactome:R-HSA-9006323|Reactome:R-HSA-9006332|Reactome:R-HSA-9011241|Reactome:R-HSA-9012650|Reactome:R-HSA-9018572|Reactome:R-HSA-9021609|Reactome:R-HSA-9024726|Reactome:R-HSA-9026464|Reactome:R-HSA-9026502|Reactome:R-HSA-9026510|Reactome:R-HSA-9026579|Reactome:R-HSA-9026890|Reactome:R-HSA-9027272|Reactome:R-HSA-9027273|Reactome:R-HSA-9027425|Reactome:R-HSA-9028728|Reactome:R-HSA-9029151|Reactome:R-HSA-9029155|Reactome:R-HSA-9032426|Reactome:R-HSA-9032532|Reactome:R-HSA-9032601|Reactome:R-HSA-9032854|Reactome:R-HSA-9033284|Reactome:R-HSA-9034714|Reactome:R-HSA-9034814|Reactome:R-HSA-9034875|Reactome:R-HSA-9037040|Reactome:R-HSA-909718|Reactome:R-HSA-909726|Reactome:R-HSA-909729|Reactome:R-HSA-909730|Reactome:R-HSA-909732|Reactome:R-HSA-912629|Reactome:R-HSA-9603420|Reactome:R-HSA-9604767|Reactome:R-HSA-9606159|Reactome:R-HSA-9606162|Reactome:R-HSA-9606163|Reactome:R-HSA-9612085|Reactome:R-HSA-9612996|Reactome:R-HSA-9613023|Reactome:R-HSA-9624014|Reactome:R-HSA-9625487|Reactome:R-HSA-9634390|Reactome:R-HSA-9664261|Reactome:R-HSA-9664275|Reactome:R-HSA-9664278|Reactome:R-HSA-9664588|Reactome:R-HSA-9664976|Reactome:R-HSA-9665032|Reactome:R-HSA-9665389|Reactome:R-HSA-9665411|Reactome:R-HSA-9665704|Reactome:R-HSA-9665705|Reactome:R-HSA-9665709|Reactome:R-HSA-9666425|Reactome:R-HSA-9669890|Reactome:R-HSA-9669911|Reactome:R-HSA-9670412|Reactome:R-HSA-9670418|Reactome:R-HSA-9672173|Reactome:R-HSA-9672175|Reactome:R-HSA-9673756|Reactome:R-HSA-9673761|Reactome:R-HSA-9674558|Reactome:R-HSA-9674567|Reactome:R-HSA-9680248|Reactome:R-HSA-9695834|Reactome:R-HSA-9698003|Reactome:R-HSA-9698005|Reactome:R-HSA-9699578|Reactome:R-HSA-9700164|Reactome:R-HSA-9700168|Reactome:R-HSA-9700171|Reactome:R-HSA-9700175|Reactome:R-HSA-9700181|Reactome:R-HSA-9700186|Reactome:R-HSA-9700193|Reactome:R-HSA-9700647|Reactome:R-HSA-9701488|Reactome:R-HSA-9703437|Reactome:R-HSA-9703438|Reactome:R-HSA-9706344|Reactome:R-HSA-9706350|Reactome:R-HSA-9709918|Reactome:R-HSA-9712082|Reactome:R-HSA-9712085|Reactome:R-HSA-9712086|Reactome:R-HSA-9712087|Reactome:R-HSA-9726848|Reactome:R-HSA-9732738|Reactome:R-HSA-9733314|Reactome:R-HSA-9733323|Reactome:R-HSA-9762209|Reactome:R-HSA-982807|Reactome:R-HSA-983703|Reactome:R-HSA-983707|Reactome:R-HSA-983709 go.json protein-tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004713 GO:0004710 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004710 GO:0004719 biolink:MolecularActivity protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. EC:2.1.1.77|MetaCyc:2.1.1.77-RXN|RHEA:12705|Reactome:R-HSA-5676966 go.json D-aspartyl/L-isoaspartyl methyltransferase activity|L-aspartyl/L-isoaspartyl protein methyltransferase activity|L-isoaspartyl protein carboxyl methyltransferase activity|L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity|S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity|protein (D-aspartate) methyltransferase activity|protein D-aspartate methyltransferase activity|protein L-isoaspartate methyltransferase activity|protein L-isoaspartyl methyltransferase activity|protein O-methyltransferase (L-isoaspartate)|protein beta-aspartate O-methyltransferase activity|protein-L-isoaspartate O-methyltransferase activity|protein-L-isoaspartate(D-aspartate) O-methyltransferase activity|protein-beta-aspartate O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0004719 GO:0004716 biolink:MolecularActivity obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. EC:2.7.10.- go.json receptor signaling protein tyrosine kinase activity|receptor signalling protein tyrosine kinase activity True http://purl.obolibrary.org/obo/GO_0004716 GO:0004715 biolink:MolecularActivity non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. EC:2.7.10.2|MetaCyc:2.7.10.1-RXN|Reactome:R-HSA-1112602|Reactome:R-HSA-1112703|Reactome:R-HSA-1168423|Reactome:R-HSA-1168459|Reactome:R-HSA-1168767|Reactome:R-HSA-1295519|Reactome:R-HSA-1369115|Reactome:R-HSA-432148|Reactome:R-HSA-437936|Reactome:R-HSA-453200|Reactome:R-HSA-6786095|Reactome:R-HSA-6786096|Reactome:R-HSA-6788582|Reactome:R-HSA-879910|Reactome:R-HSA-8871373 go.json ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|ATP:protein-tyrosine O-phosphotransferase activity|Bruton's tyrosine kinase activity|cytoplasmic protein tyrosine kinase activity|focal adhesion kinase activity|janus kinase 1 activity|janus kinase 2 activity|janus kinase 3 activity|non-specific protein-tyrosine kinase activity|p60c-src protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004715 GO:0004718 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004718 GO:0004717 biolink:MolecularActivity obsolete focal adhesion kinase activity OBSOLETE. (Was not defined before being made obsolete). go.json FAK|focal adhesion kinase activity True http://purl.obolibrary.org/obo/GO_0004717 GO:0038137 biolink:BiologicalProcess ERBB4-EGFR signaling pathway The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. go.json ERBB1-ERBB4 signaling pathway|ERBB4-EGFR signalling pathway|HER1-HER4 signaling pathway http://purl.obolibrary.org/obo/GO_0038137 GO:0038136 biolink:BiologicalProcess ERBB3-ERBB4 signaling pathway The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. go.json ERBB3-ERBB4 signalling pathway|HER3-HER4 signaling pathway http://purl.obolibrary.org/obo/GO_0038136 GO:0038139 biolink:CellularComponent ERBB4-EGFR complex A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1). go.json EGFR-ERBB4 complex|ERBB4:EGFR heterodimer http://purl.obolibrary.org/obo/GO_0038139 GO:0038138 biolink:BiologicalProcess ERBB4-ERBB4 signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. go.json ERBB4 homodimeric signaling pathway|ERBB4-ERBB4 signalling pathway|HER4-HER4 signaling pathway http://purl.obolibrary.org/obo/GO_0038138 GO:0038131 biolink:MolecularActivity neuregulin receptor activity Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json NRG receptor activity|NRG1 receptor activity|NRG2 receptor activity http://purl.obolibrary.org/obo/GO_0038131 GO:0038130 biolink:BiologicalProcess ERBB4 signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json ERBB4 signalling pathway|HER4 signaling pathway|receptor tyrosine-protein kinase erbB-4 signaling pathway http://purl.obolibrary.org/obo/GO_0038130 GO:0038133 biolink:BiologicalProcess ERBB2-ERBB3 signaling pathway The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission. go.json ERBB2-ERBB3 signalling pathway|HER2-HER3 signaling pathway http://purl.obolibrary.org/obo/GO_0038133 GO:0038132 biolink:MolecularActivity neuregulin binding Binding to a neuregulin, a member of the EGF family of growth factors. go.json http://purl.obolibrary.org/obo/GO_0038132 GO:0038135 biolink:BiologicalProcess ERBB2-ERBB4 signaling pathway The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. go.json ERBB2-ERBB4 signalling pathway|HER2-HER4 signaling pathway http://purl.obolibrary.org/obo/GO_0038135 GO:0038134 biolink:BiologicalProcess ERBB2-EGFR signaling pathway The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. go.json EGFR-HER2 signaling pathway|ERBB2-EGFR signalling pathway http://purl.obolibrary.org/obo/GO_0038134 GO:0038126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038126 GO:0038125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0038125 GO:0038128 biolink:BiologicalProcess ERBB2 signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. go.json ERBB2 signalling pathway|HER2 signaling pathway|NEU signaling|receptor tyrosine-protein kinase erbB-2 signaling pathway http://purl.obolibrary.org/obo/GO_0038128 GO:0038127 biolink:BiologicalProcess ERBB signaling pathway The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json EGF receptor family signaling pathway|EGFR family signaling pathway|ERBB signalling pathway|ErbB signaling http://purl.obolibrary.org/obo/GO_0038127 GO:0038129 biolink:BiologicalProcess ERBB3 signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission. go.json ERBB3 signalling pathway|HER3 signaling pathway|receptor tyrosine-protein kinase erbB-3 signaling pathway http://purl.obolibrary.org/obo/GO_0038129 GO:0038120 biolink:BiologicalProcess CCL21-activated CCR7 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CCL21-activated CCR7 signalling pathway http://purl.obolibrary.org/obo/GO_0038120 GO:0038122 biolink:MolecularActivity C-C motif chemokine 5 receptor activity Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CCL5 receptor activity|RANTES receptor activity|small inducible cytokine A5 receptor activity http://purl.obolibrary.org/obo/GO_0038122 GO:0038121 biolink:MolecularActivity C-C motif chemokine 21 receptor activity Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CCL21 receptor activity http://purl.obolibrary.org/obo/GO_0038121 GO:0038124 biolink:BiologicalProcess toll-like receptor TLR6:TLR2 signaling pathway The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TLR2:TLR6 signaling pathway|toll-like receptor TLR6:TLR2 signalling pathway http://purl.obolibrary.org/obo/GO_0038124 GO:0038123 biolink:BiologicalProcess toll-like receptor TLR1:TLR2 signaling pathway The series of molecular signals initiated by a ligand binding of a heterodimeric TLR1:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TLR2:TLR1 signaling pathway|toll-like receptor TLR1:TLR2 signalling pathway http://purl.obolibrary.org/obo/GO_0038123 GO:0038115 biolink:BiologicalProcess chemokine (C-C motif) ligand 19 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json C-C chemokine receptor type 7 signaling pathway|CCL19-mediated signaling pathway|chemokine (C-C motif) ligand 19 signalling pathway http://purl.obolibrary.org/obo/GO_0038115 GO:0038114 biolink:BiologicalProcess interleukin-21-mediated signaling pathway The series of molecular signals initiated by interleukin-21 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-21-mediated signaling pathway|interleukin-21-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038114 GO:0038117 biolink:MolecularActivity C-C motif chemokine 19 receptor activity Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CCL19 receptor activity http://purl.obolibrary.org/obo/GO_0038117 GO:0038116 biolink:BiologicalProcess chemokine (C-C motif) ligand 21 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json C-C chemokine receptor type 7 signaling pathway|CCL21-mediated signaling pathway|chemokine (C-C motif) ligand 21 signalling pathway http://purl.obolibrary.org/obo/GO_0038116 GO:0038119 biolink:BiologicalProcess CCL19-activated CCR7 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CCL19-activated CCR7 signalling pathway http://purl.obolibrary.org/obo/GO_0038119 GO:0038118 biolink:BiologicalProcess C-C chemokine receptor CCR7 signaling pathway The series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json C-C chemokine receptor CCR7 signalling pathway|CCR7 signaling pathway http://purl.obolibrary.org/obo/GO_0038118 GO:0038111 biolink:BiologicalProcess interleukin-7-mediated signaling pathway The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-7-mediated signaling pathway|interleukin-7-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038111 GO:0038110 biolink:BiologicalProcess interleukin-2-mediated signaling pathway The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-2-mediated signaling pathway|interleukin-2-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038110 GO:0038113 biolink:BiologicalProcess interleukin-9-mediated signaling pathway The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-9-mediated signaling pathway|interleukin-9-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038113 GO:0038112 biolink:BiologicalProcess interleukin-8-mediated signaling pathway The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-8-mediated signaling pathway|interleukin-8-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0038112 GO:0038104 biolink:CellularComponent nodal receptor complex A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell. go.json ActRIIB.ALK4.EGF-CFC complex http://purl.obolibrary.org/obo/GO_0038104 GO:0038103 biolink:MolecularActivity obsolete activin receptor antagonist activity involved in negative regulation of nodal signaling pathway OBSOLETE. Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor. go.json activin receptor antagonist activity involved in negative regulation of nodal signalling pathway|nodal antagonist activity True http://purl.obolibrary.org/obo/GO_0038103 GO:0038106 biolink:MolecularActivity choriogonadotropin hormone binding Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit. go.json chorionic gonadotrophin binding|chorionic gonadotropin binding http://purl.obolibrary.org/obo/GO_0038106 GO:0038105 biolink:BiologicalProcess sequestering of TGFbeta from receptor via TGFbeta binding Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor. go.json extracellular sequestering of TGFbeta|extracellular sequestering of transforming growth factor-beta http://purl.obolibrary.org/obo/GO_0038105 GO:0038108 biolink:BiologicalProcess negative regulation of appetite by leptin-mediated signaling pathway The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food. go.json inhibition of appetite by leptin signaling|negative regulation of appetite by leptin-mediated signalling pathway|reduction of appetite by leptin-mediated signaling|suppression of appetite by leptin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0038108 GO:0038107 biolink:BiologicalProcess obsolete nodal signaling pathway involved in determination of left/right asymmetry OBSOLETE. The series of molecular signals initiated by a nodal protein binding of to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves. go.json nodal signalling pathway involved in determination of left/right asymmetry|regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry True http://purl.obolibrary.org/obo/GO_0038107 GO:0038109 biolink:BiologicalProcess Kit signaling pathway The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell. go.json Kit signalling pathway|SCF signaling pathway|stem cell factor receptor signaling pathway|stem cell factor signaling pathway http://purl.obolibrary.org/obo/GO_0038109 GO:0038100 biolink:MolecularActivity nodal binding Binding to a nodal protein, a member of the transforming growth factor-beta superfamily. go.json http://purl.obolibrary.org/obo/GO_0038100 GO:0038102 biolink:MolecularActivity activin receptor antagonist activity Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor. go.json http://purl.obolibrary.org/obo/GO_0038102 GO:0038101 biolink:BiologicalProcess sequestering of nodal from receptor via nodal binding Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor. go.json binding to and sequestering nodal|extracellular regulation of nodal|nodal antagonist activity http://purl.obolibrary.org/obo/GO_0038101 GO:0004789 biolink:MolecularActivity thiamine-phosphate diphosphorylase activity Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate. EC:2.5.1.3|KEGG_REACTION:R03223|MetaCyc:THI-P-SYN-RXN|RHEA:22328 go.json 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity|TMP diphosphorylase activity|TMP pyrophosphorylase activity|TMP-PPase activity|thiamin-phosphate diphosphorylase activity|thiamin-phosphate pyrophosphorylase activity|thiamine monophosphate pyrophosphorylase activity|thiamine phosphate pyrophosphorylase activity|thiamine-phosphate pyrophosphorylase activity|thiamine-phosphate synthase activity http://purl.obolibrary.org/obo/GO_0004789 GO:0004788 biolink:MolecularActivity thiamine diphosphokinase activity Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. EC:2.7.6.2|MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN|RHEA:11576|Reactome:R-HSA-196761 go.json ATP:thiamin pyrophosphotransferase activity|ATP:thiamine diphosphotransferase activity|TPTase activity|thiamin diphosphokinase activity|thiamin pyrophosphokinase activity|thiamin pyrophosphotransferase activity|thiamin:ATP pyrophosphotransferase activity|thiamine pyrophosphokinase activity|thiaminokinase activity http://purl.obolibrary.org/obo/GO_0004788 GO:0004785 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004785 GO:0004784 biolink:MolecularActivity superoxide dismutase activity Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. EC:1.15.1.1|MetaCyc:SUPEROX-DISMUT-RXN|RHEA:20696|Reactome:R-HSA-1222462|Reactome:R-HSA-1222469|Reactome:R-HSA-3299680|Reactome:R-HSA-3299682|Reactome:R-HSA-3299691|Reactome:R-HSA-3777112 go.json Cu,Zn-SOD|Cu-Zn superoxide dismutase activity|Fe-SOD|Mn, Fe superoxide dismutase|Mn-SOD|SOD|SOD-1|SOD-2|SOD-3|SOD-4|SODF|SODS|copper, zinc superoxide dismutase activity|cuprein|cytocuprein|erythrocuprein|ferrisuperoxide dismutase activity|hemocuprein|hepatocuprein|iron superoxide dismutase activity|iron superoxide oxidoreductase|manganese superoxide dismutase activity|manganese superoxide oxidoreductase|nickel superoxide dismutase activity|nickel superoxide oxidoreductase|superoxide dismutase I|superoxide dismutase II|superoxide:superoxide oxidoreductase activity|zinc superoxide oxidoreductase http://purl.obolibrary.org/obo/GO_0004784 GO:0004787 biolink:MolecularActivity thiamine diphosphate phosphatase activity Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. RHEA:27998 go.json TPPase activity|thiamin pyrophosphatase activity|thiamin-pyrophosphatase activity|thiamine diphosphatase activity|thiamine pyrophosphatase activity|thiamine-diphosphatase activity|thiaminpyrophosphatase activity http://purl.obolibrary.org/obo/GO_0004787 GO:0004786 biolink:MolecularActivity obsolete Mn, Fe superoxide dismutase OBSOLETE. (Was not defined before being made obsolete). go.json Mn, Fe superoxide dismutase True http://purl.obolibrary.org/obo/GO_0004786 GO:0004781 biolink:MolecularActivity sulfate adenylyltransferase (ATP) activity Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. EC:2.7.7.4|MetaCyc:SULFATE-ADENYLYLTRANS-RXN|RHEA:18133|Reactome:R-HSA-174392|Reactome:R-HSA-3560794 go.json ATP sulfurylase activity|ATP-sulfurylase activity|ATP:sulfate adenylyltransferase activity|adenosine-5'-triphosphate sulfurylase activity|adenosinetriphosphate sulfurylase activity|adenylylsulfate pyrophosphorylase activity|sulfate adenylate transferase activity|sulfurylase activity|sulphate adenylyltransferase (ATP) activity http://purl.obolibrary.org/obo/GO_0004781 GO:0004780 biolink:MolecularActivity sulfate adenylyltransferase (ADP) activity Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate. EC:2.7.7.5|KEGG_REACTION:R00530|MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN|RHEA:16529 go.json ADP-sulfurylase activity|ADP:sulfate adenylyltransferase activity|adenosine diphosphate sulfurylase activity|sulfate (adenosine diphosphate) adenylyltransferase activity|sulphate adenylyltransferase (ADP) activity http://purl.obolibrary.org/obo/GO_0004780 GO:0004783 biolink:MolecularActivity sulfite reductase (NADPH) activity Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+. EC:1.8.1.2|MetaCyc:SULFITE-REDUCT-RXN|RHEA:13801 go.json H2S-NADP oxidoreductase activity|NADPH-dependent sulfite reductase activity|NADPH-sulfite reductase activity|NADPH:sulfite reductase flavoprotein|hydrogen-sulfide:NADP+ oxidoreductase activity|sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|sulphite reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0004783 GO:0004782 biolink:MolecularActivity sulfinoalanine decarboxylase activity Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. EC:4.1.1.29|MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN|RHEA:16877|Reactome:R-HSA-1655443 go.json 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)|3-sulfino-L-alanine carboxy-lyase activity|CADCase/CSADCase activity|CSAD|CSADCase activity|L-cysteinesulfinic acid decarboxylase activity|cysteic decarboxylase activity|cysteine-sulfinate decarboxylase activity|cysteinesulfinate decarboxylase activity|cysteinesulfinic acid decarboxylase activity|sulfoalanine decarboxylase activity|sulphinoalanine decarboxylase activity http://purl.obolibrary.org/obo/GO_0004782 GO:0004799 biolink:MolecularActivity thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. EC:2.1.1.45|KEGG_REACTION:R02101|MetaCyc:THYMIDYLATESYN-RXN|RHEA:12104|Reactome:R-HSA-73605 go.json 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity|TMP synthetase activity|dTMP synthase activity|methylenetetrahydrofolate:dUMP C-methyltransferase activity|thymidylate synthetase activity http://purl.obolibrary.org/obo/GO_0004799 GO:0004796 biolink:MolecularActivity thromboxane-A synthase activity Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). EC:5.3.99.5|KEGG_REACTION:R02268|MetaCyc:THROMBOXANE-A-SYNTHASE-RXN|RHEA:17137|Reactome:R-HSA-5603275|Reactome:R-HSA-76500 go.json (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity|(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity|cytochrome P450 CYP5|thromboxane synthase activity|thromboxane synthetase activity http://purl.obolibrary.org/obo/GO_0004796 GO:0004795 biolink:MolecularActivity threonine synthase activity Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. EC:4.2.3.1|MetaCyc:THRESYN-RXN|RHEA:10840 go.json O-phospho-L-homoserine phospho-lyase (adding water)|O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)|threonine synthetase activity http://purl.obolibrary.org/obo/GO_0004795 GO:0004798 biolink:MolecularActivity thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. EC:2.7.4.9|MetaCyc:DTMPKI-RXN|RHEA:13517 go.json ATP:dTMP phosphotransferase activity|TMPK activity|dTMP kinase activity|deoxythymidine 5'-monophosphate kinase activity|thymidine 5'-monophosphate kinase activity|thymidine monophosphate kinase activity|thymidylate monophosphate kinase activity|thymidylic acid kinase activity|thymidylic kinase activity http://purl.obolibrary.org/obo/GO_0004798 GO:0004797 biolink:MolecularActivity thymidine kinase activity Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. EC:2.7.1.21|MetaCyc:THYKI-RXN|RHEA:19129 go.json 2'-deoxythymidine kinase activity|ATP:thymidine 5'-phosphotransferase activity|deoxythymidine kinase (phosphorylating)|thymidine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004797 GO:0004792 biolink:MolecularActivity thiosulfate sulfurtransferase activity Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate. EC:2.8.1.1|KEGG_REACTION:R01931|MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN|RHEA:16881|Reactome:R-HSA-9013198 go.json rhodanase activity|rhodanese activity|thiosulfate cyanide transsulfurase activity|thiosulfate thiotransferase activity|thiosulfate:cyanide sulfurtransferase activity|thiosulphate sulphurtransferase activity http://purl.obolibrary.org/obo/GO_0004792 GO:0004791 biolink:MolecularActivity thioredoxin-disulfide reductase (NADP) activity Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. EC:1.8.1.9|KEGG_REACTION:R02016|MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN|RHEA:20345|Reactome:R-HSA-1222485|Reactome:R-HSA-3323050|Reactome:R-HSA-73646|Reactome:R-HSA-9617735 go.json NADPH:oxidized thioredoxin oxidoreductase activity|thioredoxin disulfide reductase activity|thioredoxin reductase (NADPH) activity|thioredoxin-disulfide reductase activity|thioredoxin-disulphide reductase activity http://purl.obolibrary.org/obo/GO_0004791 GO:0004794 biolink:MolecularActivity L-threonine ammonia-lyase activity Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. EC:4.3.1.19|MetaCyc:THREDEHYD-RXN|RHEA:22108|UM-BBD_reactionID:r0433 go.json L-serine dehydratase activity|L-threonine ammonia-lyase (2-oxobutanoate-forming)|L-threonine deaminase activity|L-threonine dehydratase activity|L-threonine hydro-lyase (deaminating) activity|serine deaminase activity|threonine ammonia-lyase activity|threonine deaminase activity|threonine dehydrase activity|threonine dehydratase activity http://purl.obolibrary.org/obo/GO_0004794 GO:0004793 biolink:MolecularActivity threonine aldolase activity Catalysis of the reaction: L-threonine = glycine + acetaldehyde. EC:4.1.2.5|MetaCyc:THREONINE-ALDOLASE-RXN|RHEA:19625 go.json L-threonine acetaldehyde-lyase (glycine-forming)|L-threonine acetaldehyde-lyase activity|L-threonine aldolase activity http://purl.obolibrary.org/obo/GO_0004793 GO:0004790 biolink:MolecularActivity thioether S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. EC:2.1.1.96|KEGG_REACTION:R02572|MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN|RHEA:19613 go.json S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity|S-adenosyl-L-methionine:thioether S-methyltransferase activity|thioether methyltransferase activity http://purl.obolibrary.org/obo/GO_0004790 GO:0004921 biolink:MolecularActivity interleukin-11 receptor activity Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-11 receptor activity|IL-11R|gp130 http://purl.obolibrary.org/obo/GO_0004921 GO:0004920 biolink:MolecularActivity interleukin-10 receptor activity Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-10 receptor activity|IL-10R http://purl.obolibrary.org/obo/GO_0004920 GO:0004923 biolink:MolecularActivity leukemia inhibitory factor receptor activity Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json LIF receptor activity|leukemia inhibitory factor receptor beta-protein activity http://purl.obolibrary.org/obo/GO_0004923 GO:0004929 biolink:MolecularActivity obsolete frizzled-2 receptor activity OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity. go.json frizzled-2 receptor activity True http://purl.obolibrary.org/obo/GO_0004929 GO:0004928 biolink:MolecularActivity obsolete frizzled receptor activity OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity. go.json frizzled receptor activity True http://purl.obolibrary.org/obo/GO_0004928 GO:0004925 biolink:MolecularActivity prolactin receptor activity Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004925 GO:0004924 biolink:MolecularActivity oncostatin-M receptor activity Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004924 GO:0004927 biolink:MolecularActivity obsolete sevenless receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json sevenless receptor activity True http://purl.obolibrary.org/obo/GO_0004927 GO:0004926 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004926 GO:0004932 biolink:MolecularActivity mating-type factor pheromone receptor activity Combining with a mating-type factor pheromone to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004932 GO:0004931 biolink:MolecularActivity extracellularly ATP-gated monoatomic cation channel activity Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. Reactome:R-HSA-877187 go.json P2X receptor|extracellularly ATP-gated cation channel activity|purinoceptor|purinoreceptor http://purl.obolibrary.org/obo/GO_0004931 GO:0004934 biolink:MolecularActivity mating-type alpha-factor pheromone receptor activity Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity. go.json class D G protein coupled receptor activity|class D G-protein coupled receptor activity|class D G-protein-coupled receptor activity|class D GPCR activity http://purl.obolibrary.org/obo/GO_0004934 GO:0004933 biolink:MolecularActivity mating-type a-factor pheromone receptor activity Combining with the mating-type a-factor pheromone to initiate a change in cell activity. go.json class D G protein coupled receptor activity|class D G-protein coupled receptor activity|class D G-protein-coupled receptor activity|class D GPCR activity http://purl.obolibrary.org/obo/GO_0004933 GO:0004930 biolink:MolecularActivity G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. Reactome:R-HSA-114552|Reactome:R-HSA-114558|Reactome:R-HSA-167408|Wikipedia:GPCR go.json EBV-induced receptor|Epstein-Barr Virus-induced receptor activity|G protein coupled receptor activity|G protein linked receptor activity|G-protein coupled receptor activity|G-protein coupled receptor activity, unknown ligand|G-protein linked receptor activity|GPCR activity|Mas proto-oncogene receptor activity|RDC1 receptor activity|SREB receptor|ligand-dependent GPCR activity|orphan G protein coupled receptor activity|orphan G-protein coupled receptor activity|orphan GPCR activity|receptor activity, G-protein coupled|super conserved receptor expressed in brain receptor activity http://purl.obolibrary.org/obo/GO_0004930 goslim_chembl GO:0004939 biolink:MolecularActivity beta-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. go.json beta adrenoceptor http://purl.obolibrary.org/obo/GO_0004939 GO:0004936 biolink:MolecularActivity alpha-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. go.json alpha adrenoceptor http://purl.obolibrary.org/obo/GO_0004936 GO:0004935 biolink:MolecularActivity adrenergic receptor activity Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. Wikipedia:Adrenergic_receptor go.json adrenoceptor activity http://purl.obolibrary.org/obo/GO_0004935 GO:0004938 biolink:MolecularActivity alpha2-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. go.json alpha2 adrenoceptor http://purl.obolibrary.org/obo/GO_0004938 GO:0004937 biolink:MolecularActivity alpha1-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. go.json alpha1 adrenoceptor http://purl.obolibrary.org/obo/GO_0004937 GO:0004901 biolink:MolecularActivity granulocyte macrophage colony-stimulating factor receptor activity Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CSF-2 receptor activity|CSF2R|GM-CSF receptor activity|GMC-SF receptor activity|granulocyte macrophage colony stimulating factor receptor activity http://purl.obolibrary.org/obo/GO_0004901 GO:0004900 biolink:MolecularActivity erythropoietin receptor activity Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004900 GO:0004907 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004907 GO:0004906 biolink:MolecularActivity type II interferon receptor activity Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IFN-gamma receptor activity|IFNG receptor activity|interferon-gamma receptor activity http://purl.obolibrary.org/obo/GO_0004906 GO:0004909 biolink:MolecularActivity interleukin-1, type I, activating receptor activity Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. go.json IL-1 type I, activating binding|IL-1 type I, activating receptor|interleukin-1 activating receptor activity|interleukin-1 type I receptor activity|interleukin-1, type I, activating binding http://purl.obolibrary.org/obo/GO_0004909 GO:0004908 biolink:MolecularActivity interleukin-1 receptor activity Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. Wikipedia:Interleukin-1_receptor go.json IL-1 receptor activity|IL-1R http://purl.obolibrary.org/obo/GO_0004908 GO:0004903 biolink:MolecularActivity growth hormone receptor activity Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004903 GO:0004902 biolink:MolecularActivity granulocyte colony-stimulating factor receptor activity Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CSF3R|G-CSF receptor activity|granulocyte colony stimulating factor receptor activity http://purl.obolibrary.org/obo/GO_0004902 GO:0004905 biolink:MolecularActivity type I interferon receptor activity Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. go.json interferon-alpha receptor activity|interferon-alpha/beta receptor activity|interferon-beta receptor activity|interferon-delta receptor activity|interferon-epsilon receptor activity|interferon-kappa receptor activity|interferon-omega receptor activity|interferon-tau receptor activity|interferon-zeta receptor activity|type I IFN receptor activity http://purl.obolibrary.org/obo/GO_0004905 GO:0004904 biolink:MolecularActivity interferon receptor activity Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IFN receptor activity http://purl.obolibrary.org/obo/GO_0004904 GO:0004910 biolink:MolecularActivity interleukin-1, type II, blocking receptor activity Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. go.json IL-1 type II, blocking binding|IL-1 type II, blocking receptor|interleukin-1 blocking receptor activity|interleukin-1 type II receptor activity|interleukin-1, type II, blocking binding http://purl.obolibrary.org/obo/GO_0004910 GO:0004912 biolink:MolecularActivity interleukin-3 receptor activity Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Wikipedia:Interleukin-3_receptor go.json IL-3 receptor activity|IL-3R http://purl.obolibrary.org/obo/GO_0004912 GO:0004911 biolink:MolecularActivity interleukin-2 receptor activity Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-2 receptor activity|IL-2R http://purl.obolibrary.org/obo/GO_0004911 GO:0004918 biolink:MolecularActivity interleukin-8 receptor activity Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-8 receptor activity|IL-8R http://purl.obolibrary.org/obo/GO_0004918 GO:0004917 biolink:MolecularActivity interleukin-7 receptor activity Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-7 receptor activity|IL-7R http://purl.obolibrary.org/obo/GO_0004917 GO:0004919 biolink:MolecularActivity interleukin-9 receptor activity Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-9 receptor activity|IL-9R http://purl.obolibrary.org/obo/GO_0004919 GO:0004914 biolink:MolecularActivity interleukin-5 receptor activity Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-5 receptor activity|IL-5R http://purl.obolibrary.org/obo/GO_0004914 GO:0004913 biolink:MolecularActivity interleukin-4 receptor activity Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-4 receptor activity|IL-4R http://purl.obolibrary.org/obo/GO_0004913 GO:0004915 biolink:MolecularActivity interleukin-6 receptor activity Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-6 receptor activity|IL-6R|gp130 http://purl.obolibrary.org/obo/GO_0004915 GO:0004888 biolink:MolecularActivity transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. Reactome:R-HSA-193672 go.json transmembrane receptor activity|transmembrane signalling receptor activity http://purl.obolibrary.org/obo/GO_0004888 GO:0004887 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004887 GO:0004889 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004889 GO:0004884 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004884 GO:0004883 biolink:MolecularActivity nuclear glucocorticoid receptor activity Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function. go.json glucocorticoid receptor activity http://purl.obolibrary.org/obo/GO_0004883 GO:0004886 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004886 GO:0004880 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004880 GO:0004882 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004882 GO:0004899 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004899 GO:0004898 biolink:MolecularActivity obsolete gp130 OBSOLETE. (Was not defined before being made obsolete). go.json gp130 True http://purl.obolibrary.org/obo/GO_0004898 GO:0004895 biolink:MolecularActivity cell adhesion receptor activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins. go.json http://purl.obolibrary.org/obo/GO_0004895 GO:0004894 biolink:MolecularActivity obsolete T cell receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json T cell receptor activity True http://purl.obolibrary.org/obo/GO_0004894 GO:0004897 biolink:MolecularActivity ciliary neurotrophic factor receptor activity Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json CNTF receptor activity|gp130 http://purl.obolibrary.org/obo/GO_0004897 GO:0004896 biolink:MolecularActivity cytokine receptor activity Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL receptor|hematopoietin/interferon-class (D200-domain) cytokine receptor activity|interleukin receptor activity http://purl.obolibrary.org/obo/GO_0004896 GO:0004891 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004891 GO:0004890 biolink:MolecularActivity GABA-A receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. go.json ionotropic GABA receptor activity http://purl.obolibrary.org/obo/GO_0004890 GO:0004892 biolink:MolecularActivity obsolete B cell receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json B cell receptor activity True http://purl.obolibrary.org/obo/GO_0004892 GO:0004866 biolink:MolecularActivity endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of an endopeptidase. go.json alpha-2 macroglobulin|endoproteinase inhibitor|proteinase inhibitor http://purl.obolibrary.org/obo/GO_0004866 GO:0004865 biolink:MolecularActivity protein serine/threonine phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. go.json http://purl.obolibrary.org/obo/GO_0004865 GO:0004868 biolink:MolecularActivity obsolete serpin OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin. go.json serpin True http://purl.obolibrary.org/obo/GO_0004868 GO:0004867 biolink:MolecularActivity serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. Reactome:R-HSA-158795|Reactome:R-HSA-158800|Reactome:R-HSA-158893|Reactome:R-HSA-159001|Reactome:R-HSA-159005 go.json serine protease inhibitor activity|serine proteinase inhibitor activity|serpin activity http://purl.obolibrary.org/obo/GO_0004867 GO:0004862 biolink:MolecularActivity cAMP-dependent protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. Reactome:R-HSA-180073 go.json http://purl.obolibrary.org/obo/GO_0004862 GO:0004861 biolink:MolecularActivity cyclin-dependent protein serine/threonine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. Reactome:R-HSA-187934|Reactome:R-HSA-69562 go.json CDK inhibitor|cyclin dependent kinase inhibitor|cyclin dependent protein kinase inhibitor activity|cyclin-dependent kinase inhibitor|cyclin-dependent protein kinase inhibitor activity http://purl.obolibrary.org/obo/GO_0004861 GO:0004864 biolink:MolecularActivity protein phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein phosphatase. go.json phosphoprotein phosphatase inhibitor activity|protein phosphatase 2 inhibitor activity|protein phosphatase type 2A inhibitor activity http://purl.obolibrary.org/obo/GO_0004864 GO:0004863 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004863 GO:0004860 biolink:MolecularActivity protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein kinase. go.json http://purl.obolibrary.org/obo/GO_0004860 GO:0004869 biolink:MolecularActivity cysteine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. go.json cystatin|cysteine protease inhibitor activity|thiol protease inhibitor http://purl.obolibrary.org/obo/GO_0004869 GO:0004877 biolink:MolecularActivity complement component C3b receptor activity Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004877 GO:0004876 biolink:MolecularActivity complement component C3a receptor activity Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json C3a anaphylatoxin receptor activity http://purl.obolibrary.org/obo/GO_0004876 GO:0004879 biolink:MolecularActivity nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. go.json 1,25-(OH)2D3 receptor activity|9-cis retinoic acid receptor activity|RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding|RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|RXR|androgen receptor activity|calcitriol receptor activity|ecdysteroid hormone receptor activity|estrogen nuclear receptor activity|glucocorticoid receptor activity|juvenile hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|ligand-dependent nuclear receptor activity|ligand-dependent transcription factor activity|nuclear hormone receptor|retinoic acid receptor activity|retinoid-X receptor activity|thyroid hormone receptor activity|vitamin A receptor activity|vitamin D receptor activity|vitamin D3 receptor activity http://purl.obolibrary.org/obo/GO_0004879 GO:0004878 biolink:MolecularActivity complement component C5a receptor activity Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json C5a anaphylatoxin receptor activity http://purl.obolibrary.org/obo/GO_0004878 GO:0004873 biolink:MolecularActivity asialoglycoprotein receptor activity Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. go.json http://purl.obolibrary.org/obo/GO_0004873 goslim_chembl GO:0004872 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004872 GO:0004875 biolink:MolecularActivity complement receptor activity Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json anaphylatoxin receptor activity http://purl.obolibrary.org/obo/GO_0004875 GO:0004874 biolink:MolecularActivity obsolete aryl hydrocarbon receptor activity OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding. go.json True http://purl.obolibrary.org/obo/GO_0004874 GO:0004871 biolink:MolecularActivity obsolete signal transducer activity OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. go.json hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity|quorum sensing response regulator activity|quorum sensing signal generator activity True http://purl.obolibrary.org/obo/GO_0004871 GO:0004870 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004870 GO:0004844 biolink:MolecularActivity uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. EC:3.2.2.27|Reactome:R-HSA-110215|Reactome:R-HSA-110217|Reactome:R-HSA-9817512|https://github.com/geneontology/go-ontology/issues/25051 go.json uracil-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0004844 GO:0004843 biolink:MolecularActivity cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. EC:3.4.19.12|Reactome:R-HSA-1358795|Reactome:R-HSA-2179291|Reactome:R-HSA-3215295|Reactome:R-HSA-3215310|Reactome:R-HSA-3640872|Reactome:R-HSA-4641236|Reactome:R-HSA-5653770|Reactome:R-HSA-5655466|Reactome:R-HSA-5688797|Reactome:R-HSA-5688837|Reactome:R-HSA-5689950|Reactome:R-HSA-5689972|Reactome:R-HSA-5689973|Reactome:R-HSA-5690080|Reactome:R-HSA-5690152|Reactome:R-HSA-5690157|Reactome:R-HSA-5690159|Reactome:R-HSA-5690196|Reactome:R-HSA-5690319|Reactome:R-HSA-5690759|Reactome:R-HSA-5690790|Reactome:R-HSA-5691381|Reactome:R-HSA-5696465|Reactome:R-HSA-5696534|Reactome:R-HSA-5696564|Reactome:R-HSA-5696600|Reactome:R-HSA-5696605|Reactome:R-HSA-5696627|Reactome:R-HSA-5696872|Reactome:R-HSA-5696914|Reactome:R-HSA-5696945|Reactome:R-HSA-5696947|Reactome:R-HSA-5696958|Reactome:R-HSA-5696960|Reactome:R-HSA-5696968|Reactome:R-HSA-5696997|Reactome:R-HSA-5697009|Reactome:R-HSA-6781764|Reactome:R-HSA-6781779|Reactome:R-HSA-6781814|Reactome:R-HSA-6781897|Reactome:R-HSA-6782069|Reactome:R-HSA-6782106|Reactome:R-HSA-6782628|Reactome:R-HSA-6782820|Reactome:R-HSA-6783177|Reactome:R-HSA-6786171|Reactome:R-HSA-6807118|Reactome:R-HSA-6807206|Reactome:R-HSA-870437|Reactome:R-HSA-8853503|Reactome:R-HSA-8853514|Reactome:R-HSA-8853515|Reactome:R-HSA-8853529|Reactome:R-HSA-8862184|Reactome:R-HSA-8865182|Reactome:R-HSA-8869456|Reactome:R-HSA-8873946|Reactome:R-HSA-8875443|Reactome:R-HSA-8986083|Reactome:R-HSA-9033478|Reactome:R-HSA-9033491|Reactome:R-HSA-9653514 go.json UBP|UCH2|deubiquitinase|deubiquitinase activity|deubiquitinating enzyme|deubiquitylase|thiol-dependent deubiquitinase|thiol-dependent ubiquitin-specific protease activity|thiol-dependent ubiquitinyl hydrolase activity|ubiquitin C-terminal hydrolase|ubiquitin hydrolase activity|ubiquitin-specific protease activity|ubiquitinyl hydrolase 1 activity|ubiquitinyl hydrolase activity http://purl.obolibrary.org/obo/GO_0004843 GO:0004846 biolink:MolecularActivity urate oxidase activity Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. EC:1.7.3.3|MetaCyc:URATE-OXIDASE-RXN|RHEA:21368|UM-BBD_reactionID:r1322 go.json urate:oxygen oxidoreductase activity|uric acid oxidase activity|uricase II activity|uricase activity http://purl.obolibrary.org/obo/GO_0004846 GO:0004845 biolink:MolecularActivity uracil phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil. EC:2.4.2.9|KEGG_REACTION:R00966|MetaCyc:URACIL-PRIBOSYLTRANS-RXN|RHEA:13017 go.json UMP diphosphorylase activity|UMP pyrophosphorylase activity|UMP:diphosphate phospho-alpha-D-ribosyltransferase activity|UMP:pyrophosphate phosphoribosyltransferase activity|UPRTase activity|uridine 5'-phosphate pyrophosphorylase activity|uridine monophosphate pyrophosphorylase activity|uridylate pyrophosphorylase activity|uridylic pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0004845 GO:0004840 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004840 GO:0004842 biolink:MolecularActivity ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. KEGG_REACTION:R03876|Reactome:R-HSA-1169394|Reactome:R-HSA-1169395|Reactome:R-HSA-1169397|Reactome:R-HSA-1169398|Reactome:R-HSA-1169402|Reactome:R-HSA-1169405|Reactome:R-HSA-1169406|Reactome:R-HSA-1234163|Reactome:R-HSA-1234172|Reactome:R-HSA-1253282|Reactome:R-HSA-1358789|Reactome:R-HSA-1358790|Reactome:R-HSA-1358792|Reactome:R-HSA-1363331|Reactome:R-HSA-168915|Reactome:R-HSA-173542|Reactome:R-HSA-173545|Reactome:R-HSA-174057|Reactome:R-HSA-174104|Reactome:R-HSA-174144|Reactome:R-HSA-174159|Reactome:R-HSA-174195|Reactome:R-HSA-174227|Reactome:R-HSA-179417|Reactome:R-HSA-180540|Reactome:R-HSA-180597|Reactome:R-HSA-182986|Reactome:R-HSA-182993|Reactome:R-HSA-183036|Reactome:R-HSA-183051|Reactome:R-HSA-183084|Reactome:R-HSA-183089|Reactome:R-HSA-1852623|Reactome:R-HSA-187575|Reactome:R-HSA-1912357|Reactome:R-HSA-1912386|Reactome:R-HSA-1918092|Reactome:R-HSA-1918095|Reactome:R-HSA-1977296|Reactome:R-HSA-1980074|Reactome:R-HSA-1980118|Reactome:R-HSA-201425|Reactome:R-HSA-202453|Reactome:R-HSA-202534|Reactome:R-HSA-205118|Reactome:R-HSA-209063|Reactome:R-HSA-211734|Reactome:R-HSA-2169050|Reactome:R-HSA-2172172|Reactome:R-HSA-2179276|Reactome:R-HSA-2186747|Reactome:R-HSA-2186785|Reactome:R-HSA-2187368|Reactome:R-HSA-2213017|Reactome:R-HSA-264444|Reactome:R-HSA-2682349|Reactome:R-HSA-2730904|Reactome:R-HSA-2737728|Reactome:R-HSA-2769007|Reactome:R-HSA-2900765|Reactome:R-HSA-3000335|Reactome:R-HSA-3134804|Reactome:R-HSA-3134946|Reactome:R-HSA-3249386|Reactome:R-HSA-3780995|Reactome:R-HSA-3781009|Reactome:R-HSA-3788724|Reactome:R-HSA-3797226|Reactome:R-HSA-400267|Reactome:R-HSA-4332236|Reactome:R-HSA-446877|Reactome:R-HSA-450358|Reactome:R-HSA-451418|Reactome:R-HSA-5205682|Reactome:R-HSA-5357757|Reactome:R-HSA-5362412|Reactome:R-HSA-5483238|Reactome:R-HSA-5607725|Reactome:R-HSA-5607728|Reactome:R-HSA-5607756|Reactome:R-HSA-5607757|Reactome:R-HSA-5610742|Reactome:R-HSA-5610745|Reactome:R-HSA-5610746|Reactome:R-HSA-5652009|Reactome:R-HSA-5655170|Reactome:R-HSA-5660753|Reactome:R-HSA-5667107|Reactome:R-HSA-5667111|Reactome:R-HSA-5668454|Reactome:R-HSA-5668534|Reactome:R-HSA-5675470|Reactome:R-HSA-5684250|Reactome:R-HSA-5691108|Reactome:R-HSA-5693108|Reactome:R-HSA-68712|Reactome:R-HSA-69598|Reactome:R-HSA-741386|Reactome:R-HSA-75824|Reactome:R-HSA-870449|Reactome:R-HSA-8948709|Reactome:R-HSA-8956106|Reactome:R-HSA-9013069|Reactome:R-HSA-9013974|Reactome:R-HSA-9014342|Reactome:R-HSA-918224|Reactome:R-HSA-936412|Reactome:R-HSA-936942|Reactome:R-HSA-936986|Reactome:R-HSA-9628444|Reactome:R-HSA-9645394|Reactome:R-HSA-9645414|Reactome:R-HSA-9688831|Reactome:R-HSA-9701000|Reactome:R-HSA-9750946|Reactome:R-HSA-975118|Reactome:R-HSA-975147|Reactome:R-HSA-9758604|Reactome:R-HSA-9793444|Reactome:R-HSA-9793485|Reactome:R-HSA-9793679|Reactome:R-HSA-9796346|Reactome:R-HSA-9796387|Reactome:R-HSA-9796626|Reactome:R-HSA-9815507|Reactome:R-HSA-9817362|Reactome:R-HSA-983140|Reactome:R-HSA-983153|Reactome:R-HSA-983156|Reactome:R-HSA-9833973 go.json E2|E3|ubiquitin conjugating enzyme activity|ubiquitin ligase activity|ubiquitin protein ligase activity|ubiquitin protein-ligase activity|ubiquitin-conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0004842 GO:0004841 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004841 GO:0004848 biolink:MolecularActivity ureidoglycolate hydrolase activity Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4. EC:3.5.3.19|KEGG_REACTION:R00469|MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN|RHEA:19809 go.json (S)-ureidoglycolate amidohydrolase (decarboxylating) http://purl.obolibrary.org/obo/GO_0004848 GO:0004847 biolink:MolecularActivity urea carboxylase activity Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate. EC:6.3.4.6|KEGG_REACTION:R00774|MetaCyc:UREA-CARBOXYLASE-RXN|RHEA:20896 go.json ATP--urea amidolyase activity|UALase activity|UCA activity|urea amidolyase activity|urea carboxylase (hydrolysing)|urea carboxylase (hydrolyzing) activity|urea:carbon-dioxide ligase (ADP-forming)|urease (ATP-hydrolysing)|urease (ATP-hydrolyzing) activity http://purl.obolibrary.org/obo/GO_0004847 GO:0004849 biolink:MolecularActivity uridine kinase activity Catalysis of the reaction: ATP + uridine = ADP + UMP. MetaCyc:URIDINEKIN-RXN|RHEA:16825|Reactome:R-HSA-8954327 go.json uridine phosphokinase activity|uridine-cytidine kinase activity http://purl.obolibrary.org/obo/GO_0004849 GO:0004855 biolink:MolecularActivity xanthine oxidase activity Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. EC:1.17.3.2|MetaCyc:XANTHINE-OXIDASE-RXN|RHEA:21132|Reactome:R-HSA-74258|Reactome:R-HSA-9748991|UM-BBD_enzymeID:e0781 go.json Schardinger enzyme activity|hypoxanthine-xanthine oxidase activity|schardinger enzyme|xanthine oxidoreductase activity|xanthine:O2 oxidoreductase activity|xanthine:oxygen oxidoreductase activity|xanthine:xanthine oxidase activity http://purl.obolibrary.org/obo/GO_0004855 GO:0004854 biolink:MolecularActivity xanthine dehydrogenase activity Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. EC:1.17.1.4|MetaCyc:RXN0-901|RHEA:16669|Reactome:R-HSA-9727349 go.json NAD-xanthine dehydrogenase activity|xanthine oxidoreductase activity|xanthine-NAD oxidoreductase activity|xanthine/NAD(+) oxidoreductase activity|xanthine/NAD+ oxidoreductase activity|xanthine:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004854 GO:0004857 biolink:MolecularActivity enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme. go.json metalloenzyme inhibitor activity http://purl.obolibrary.org/obo/GO_0004857 GO:0004856 biolink:MolecularActivity xylulokinase activity Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+. EC:2.7.1.17|KEGG_REACTION:R01639|MetaCyc:XYLULOKIN-RXN|RHEA:10964|Reactome:R-HSA-5662466 go.json ATP:D-xylulose 5-phosphotransferase activity|D-xylulokinase activity|xylulokinase (phosphorylating)|xylulose kinase activity http://purl.obolibrary.org/obo/GO_0004856 GO:0004851 biolink:MolecularActivity uroporphyrin-III C-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2. EC:2.1.1.107|MetaCyc:UROPORIIIMETHYLTRANSA-RXN|RHEA:32459 go.json CobA|CysG|S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity|S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity|S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity|SUMT activity|SirA|adenosylmethionine-uroporphyrinogen III methyltransferase activity|urogen III methylase activity|uroporphyrinogen III methylase activity|uroporphyrinogen methyltransferase activity|uroporphyrinogen-III C-methyltransferase activity|uroporphyrinogen-III methylase activity|uroporphyrinogen-III methyltransferase activity http://purl.obolibrary.org/obo/GO_0004851 GO:0004850 biolink:MolecularActivity uridine phosphorylase activity Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. EC:2.4.2.3|MetaCyc:URPHOS-RXN|RHEA:24388|Reactome:R-HSA-74372|Reactome:R-HSA-74376 go.json UPH|UPase activity|UrdPase activity|pyrimidine phosphorylase activity|uridine:phosphate alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0004850 GO:0004853 biolink:MolecularActivity uroporphyrinogen decarboxylase activity Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. EC:4.1.1.37|MetaCyc:UROGENDECARBOX-RXN|RHEA:19865|Reactome:R-HSA-189425|Reactome:R-HSA-190182 go.json porphyrinogen carboxy-lyase activity|porphyrinogen decarboxylase activity|uroporphyrinogen III decarboxylase activity|uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)|uroporphyrinogen-III carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0004853 GO:0004852 biolink:MolecularActivity uroporphyrinogen-III synthase activity Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. EC:4.2.1.75|KEGG_REACTION:R03165|MetaCyc:UROGENIIISYN-RXN|RHEA:18965|Reactome:R-HSA-189488 go.json URO-synthase activity|hydroxymethylbilane hydro-lyase (cyclizing) activity|hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)|porphobilinogenase activity|uroporphyrinogen III cosynthase activity|uroporphyrinogen isomerase activity|uroporphyrinogen-III cosynthase activity|uroporphyrinogen-III cosynthetase activity http://purl.obolibrary.org/obo/GO_0004852 GO:0004859 biolink:MolecularActivity phospholipase inhibitor activity Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. go.json http://purl.obolibrary.org/obo/GO_0004859 GO:0004858 biolink:MolecularActivity dUTP pyrophosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase. go.json http://purl.obolibrary.org/obo/GO_0004858 GO:0004822 biolink:MolecularActivity isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+. EC:6.1.1.5|KEGG_REACTION:R03656|MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN|RHEA:11060|Reactome:R-HSA-379893|Reactome:R-HSA-380176 go.json L-isoleucine:tRNAIle ligase (AMP-forming)|isoleucine translase activity|isoleucine-tRNA synthetase activity|isoleucine-transfer RNA ligase activity|isoleucyl-tRNA synthetase activity|isoleucyl-transfer RNA synthetase activity|isoleucyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_0004822 GO:0004821 biolink:MolecularActivity histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). EC:6.1.1.21|MetaCyc:HISTIDINE--TRNA-LIGASE-RXN|RHEA:17313|Reactome:R-HSA-379844|Reactome:R-HSA-380234 go.json L-histidine:tRNAHis ligase (AMP-forming)|histidine translase activity|histidyl-tRNA synthetase activity|histidyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_0004821 GO:0004824 biolink:MolecularActivity lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). EC:6.1.1.6|MetaCyc:LYSINE--TRNA-LIGASE-RXN|RHEA:20792|Reactome:R-HSA-380008|Reactome:R-HSA-380233 go.json L-lysine-transfer RNA ligase activity|L-lysine:tRNALys ligase (AMP-forming)|lysine translase activity|lysine-tRNA synthetase activity|lysyl-tRNA synthetase activity|lysyl-transfer RNA synthetase activity|lysyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_0004824 GO:0004823 biolink:MolecularActivity leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu). EC:6.1.1.4|KEGG_REACTION:R03657|MetaCyc:LEUCINE--TRNA-LIGASE-RXN|RHEA:11688|Reactome:R-HSA-379974|Reactome:R-HSA-380200 go.json L-leucine:tRNALeu ligase (AMP-forming)|leucine translase activity|leucine-tRNA synthetase activity|leucyl-tRNA synthetase activity|leucyl-transfer RNA synthetase activity|leucyl-transfer ribonucleate synthetase activity|leucyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004823 GO:0004820 biolink:MolecularActivity glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). EC:6.1.1.14|MetaCyc:GLYCINE--TRNA-LIGASE-RXN|RHEA:16013|Reactome:R-HSA-380048|Reactome:R-HSA-380240 go.json glycine:tRNAGly ligase (AMP-forming) activity|glycyl translase activity|glycyl-tRNA synthetase activity|glycyl-transfer RNA synthetase activity|glycyl-transfer ribonucleate synthetase activity|glycyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004820 GO:0004829 biolink:MolecularActivity threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). EC:6.1.1.3|MetaCyc:THREONINE--TRNA-LIGASE-RXN|RHEA:24624|Reactome:R-HSA-380002|Reactome:R-HSA-380201 go.json L-threonine:tRNAThr ligase (AMP-forming)|TRS|threonine translase activity|threonine-transfer ribonucleate synthetase activity|threonyl ribonucleic synthetase activity|threonyl-tRNA synthetase activity|threonyl-transfer RNA synthetase activity|threonyl-transfer ribonucleate synthetase activity|threonyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004829 GO:0004826 biolink:MolecularActivity phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). EC:6.1.1.20|MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN|RHEA:19413|Reactome:R-HSA-379848|Reactome:R-HSA-380203 go.json L-phenylalanine:tRNAPhe ligase (AMP-forming) activity|L-phenylalanyl-tRNA synthetase activity|phenylalanine translase activity|phenylalanine-tRNA synthetase activity|phenylalanyl-tRNA ligase activity|phenylalanyl-tRNA synthetase activity|phenylalanyl-transfer RNA ligase activity|phenylalanyl-transfer RNA synthetase activity|phenylalanyl-transfer ribonucleate synthetase activity http://purl.obolibrary.org/obo/GO_0004826 GO:0004825 biolink:MolecularActivity methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). EC:6.1.1.10|MetaCyc:METHIONINE--TRNA-LIGASE-RXN|RHEA:13481|Reactome:R-HSA-379994|Reactome:R-HSA-380157 go.json L-methionine:tRNAMet ligase (AMP-forming)|MetRS activity|methionine translase activity|methionyl-tRNA synthetase activity|methionyl-transfer RNA synthetase activity|methionyl-transfer ribonucleate synthetase activity|methionyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004825 GO:0004828 biolink:MolecularActivity serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). EC:6.1.1.11|MetaCyc:SERINE--TRNA-LIGASE-RXN|RHEA:12292|Reactome:R-HSA-379992|Reactome:R-HSA-380239 go.json L-serine:tRNASer ligase (AMP-forming)|SerRS activity|serine translase activity|seryl-tRNA synthetase activity|seryl-transfer RNA synthetase activity|seryl-transfer ribonucleate synthetase activity|seryl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004828 GO:0004827 biolink:MolecularActivity proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). EC:6.1.1.15|MetaCyc:PROLINE--TRNA-LIGASE-RXN|RHEA:14305|Reactome:R-HSA-379865|Reactome:R-HSA-380198 go.json L-proline:tRNAPro ligase (AMP-forming)|proline translase activity|prolinyl-tRNA ligase activity|prolyl-s-RNA synthetase activity|prolyl-tRNA synthetase activity|prolyl-transfer ribonucleate synthetase activity|prolyl-transfer ribonucleic acid synthetase activity|prolyl-transferRNA synthetase activity http://purl.obolibrary.org/obo/GO_0004827 GO:0004833 biolink:MolecularActivity tryptophan 2,3-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. EC:1.13.11.11|MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN|RHEA:24536|Reactome:R-HSA-198563|Reactome:R-HSA-71188|Reactome:R-HSA-888614 go.json L-tryptophan 2,3-dioxygenase activity|L-tryptophan pyrrolase activity|L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)|TDO|indolamine 2,3-dioxygenase activity|indoleamine-pyrrole 2,3-dioxygenase activity|tryptamin 2,3-dioxygenase activity|tryptamine 2,3-dioxygenase activity|tryptophan oxygenase activity|tryptophan peroxidase activity|tryptophan pyrrolase activity http://purl.obolibrary.org/obo/GO_0004833 GO:0004832 biolink:MolecularActivity valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+. EC:6.1.1.9|KEGG_REACTION:R03665|MetaCyc:VALINE--TRNA-LIGASE-RXN|RHEA:10704|Reactome:R-HSA-380042|Reactome:R-HSA-380199 go.json L-valine:tRNAVal ligase (AMP-forming)|valine transfer ribonucleate ligase activity|valine translase activity|valyl-tRNA synthetase activity|valyl-transfer RNA synthetase activity|valyl-transfer ribonucleate synthetase activity|valyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004832 GO:0004835 biolink:MolecularActivity tubulin-tyrosine ligase activity Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. EC:6.3.2.25|MetaCyc:6.3.2.25-RXN|RHEA:17605|Reactome:R-HSA-8955706 go.json TTL activity|alpha-tubulin:L-tyrosine ligase (ADP-forming)|tubulinyl-tyrosine ligase activity http://purl.obolibrary.org/obo/GO_0004835 GO:0004834 biolink:MolecularActivity tryptophan synthase activity Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. EC:4.2.1.20|KEGG_REACTION:R02722|MetaCyc:TRYPSYN-RXN|RHEA:10532 go.json L-serine hydro-lyase (adding indoleglycerol-phosphate)|L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]|L-tryptophan synthetase activity|indoleglycerol phosphate aldolase activity|tryptophan desmolase activity|tryptophan synthetase activity http://purl.obolibrary.org/obo/GO_0004834 GO:0004831 biolink:MolecularActivity tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. EC:6.1.1.1|KEGG_REACTION:R02918|MetaCyc:TYROSINE--TRNA-LIGASE-RXN|RHEA:10220|Reactome:R-HSA-379980|Reactome:R-HSA-380170 go.json L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity|L-tyrosine-tRNATyr ligase (AMP-forming)|L-tyrosine:tRNATyr ligase (AMP-forming)|tyrosine tRNA synthetase activity|tyrosine translase activity|tyrosine-transfer RNA ligase activity|tyrosine-transfer ribonucleate synthetase activity|tyrosyl-tRNA ligase activity|tyrosyl-tRNA synthetase activity|tyrosyl-transfer RNA synthetase activity|tyrosyl-transfer ribonucleate synthetase activity|tyrosyl-transfer ribonucleic acid synthetase activity http://purl.obolibrary.org/obo/GO_0004831 GO:0004830 biolink:MolecularActivity tryptophan-tRNA ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). EC:6.1.1.2|MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN|RHEA:24080|Reactome:R-HSA-379977|Reactome:R-HSA-380222 go.json L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity|L-tryptophan-tRNATrp ligase (AMP-forming)|L-tryptophan:tRNATrp ligase (AMP-forming)|TrpRS activity|tryptophan translase activity|tryptophanyl ribonucleic synthetase activity|tryptophanyl-tRNA synthase activity|tryptophanyl-tRNA synthetase activity|tryptophanyl-transfer RNA synthetase activity|tryptophanyl-transfer ribonucleate synthetase activity|tryptophanyl-transfer ribonucleic acid synthetase activity|tryptophanyl-transfer ribonucleic synthetase activity http://purl.obolibrary.org/obo/GO_0004830 GO:0004837 biolink:MolecularActivity tyrosine decarboxylase activity Catalysis of the reaction: L-tyrosine = tyramine + CO2. EC:4.1.1.25|MetaCyc:TYROSINE-DECARBOXYLASE-RXN|RHEA:14345 go.json L-(-)-tyrosine apodecarboxylase activity|L-tyrosine carboxy-lyase (tyramine-forming)|L-tyrosine carboxy-lyase activity|L-tyrosine decarboxylase activity http://purl.obolibrary.org/obo/GO_0004837 GO:0004836 biolink:MolecularActivity tyramine-beta hydroxylase activity Catalysis of the hydroxylation of tyramine to form octopamine. go.json http://purl.obolibrary.org/obo/GO_0004836 GO:0004839 biolink:MolecularActivity ubiquitin activating enzyme activity Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. EC:6.2.1.45|Reactome:R-HSA-8852132|Reactome:R-HSA-8852133|Reactome:R-HSA-8852134|Reactome:R-HSA-8865050|Reactome:R-HSA-8865090|Reactome:R-HSA-8865098 go.json E1 ubiquitin-activating enzyme http://purl.obolibrary.org/obo/GO_0004839 GO:0004838 biolink:MolecularActivity L-tyrosine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. EC:2.6.1.5|MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN|RHEA:15093|Reactome:R-HSA-517444|Reactome:R-HSA-71155 go.json L-phenylalanine 2-oxoglutarate aminotransferase activity|L-tyrosine aminotransferase activity|TyrAT activity|glutamic phenylpyruvic aminotransferase activity|glutamic-hydroxyphenylpyruvic transaminase activity|phenylalanine aminotransferase activity|phenylalanine transaminase activity|phenylalanine-alpha-ketoglutarate transaminase activity|phenylpyruvate transaminase activity|phenylpyruvic acid transaminase activity|tyrosine aminotransferase activity|tyrosine transaminase activity|tyrosine-2-ketoglutarate aminotransferase activity|tyrosine-alpha-ketoglutarate aminotransferase activity|tyrosine-alpha-ketoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0004838 GO:0038203 biolink:BiologicalProcess TORC2 signaling A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. go.json TORC2 signal transduction http://purl.obolibrary.org/obo/GO_0038203 GO:0038202 biolink:BiologicalProcess TORC1 signaling A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. go.json TORC1 signal transduction http://purl.obolibrary.org/obo/GO_0038202 GO:0038201 biolink:CellularComponent TOR complex A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. go.json TOR signaling complex|mTOR complex|target of rapamycin complex http://purl.obolibrary.org/obo/GO_0038201 GO:0038200 biolink:MolecularActivity ethylene receptor histidine kinase activity Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. go.json http://purl.obolibrary.org/obo/GO_0038200 GO:1903189 biolink:BiologicalProcess glyoxal metabolic process The chemical reactions and pathways involving glyoxal. go.json glyoxal metabolism http://purl.obolibrary.org/obo/GO_1903189 GO:1903199 biolink:BiologicalProcess negative regulation of L-dopa decarboxylase activity Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa decarboxylase activity. go.json down regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|down regulation of DDC activity|down regulation of DOPA decarboxylase activity|down regulation of L-dopa decarboxylase activity|down-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|down-regulation of DDC activity|down-regulation of DOPA decarboxylase activity|down-regulation of L-dopa decarboxylase activity|downregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|downregulation of DDC activity|downregulation of DOPA decarboxylase activity|downregulation of L-dopa decarboxylase activity|inhibition of 4-dihydroxyl-L-phenylalanine decarboxylase activity|inhibition of DDC activity|inhibition of DOPA decarboxylase activity|inhibition of L-dopa decarboxylase activity|negative regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|negative regulation of DDC activity|negative regulation of DOPA decarboxylase activity http://purl.obolibrary.org/obo/GO_1903199 gocheck_do_not_annotate GO:1903198 biolink:BiologicalProcess regulation of L-dopa decarboxylase activity Any process that modulates the frequency, rate or extent of L-dopa decarboxylase activity. go.json regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|regulation of DDC activity|regulation of DOPA decarboxylase activity http://purl.obolibrary.org/obo/GO_1903198 gocheck_do_not_annotate GO:1903197 biolink:BiologicalProcess positive regulation of L-dopa biosynthetic process Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process. go.json activation of L-dopa anabolism|activation of L-dopa biosynthesis|activation of L-dopa biosynthetic process|activation of L-dopa formation|activation of L-dopa synthesis|positive regulation of L-dopa anabolism|positive regulation of L-dopa biosynthesis|positive regulation of L-dopa formation|positive regulation of L-dopa synthesis|up regulation of L-dopa anabolism|up regulation of L-dopa biosynthesis|up regulation of L-dopa biosynthetic process|up regulation of L-dopa formation|up regulation of L-dopa synthesis|up-regulation of L-dopa anabolism|up-regulation of L-dopa biosynthesis|up-regulation of L-dopa biosynthetic process|up-regulation of L-dopa formation|up-regulation of L-dopa synthesis|upregulation of L-dopa anabolism|upregulation of L-dopa biosynthesis|upregulation of L-dopa biosynthetic process|upregulation of L-dopa formation|upregulation of L-dopa synthesis http://purl.obolibrary.org/obo/GO_1903197 GO:1903196 biolink:BiologicalProcess negative regulation of L-dopa biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process. go.json down regulation of L-dopa anabolism|down regulation of L-dopa biosynthesis|down regulation of L-dopa biosynthetic process|down regulation of L-dopa formation|down regulation of L-dopa synthesis|down-regulation of L-dopa anabolism|down-regulation of L-dopa biosynthesis|down-regulation of L-dopa biosynthetic process|down-regulation of L-dopa formation|down-regulation of L-dopa synthesis|downregulation of L-dopa anabolism|downregulation of L-dopa biosynthesis|downregulation of L-dopa biosynthetic process|downregulation of L-dopa formation|downregulation of L-dopa synthesis|inhibition of L-dopa anabolism|inhibition of L-dopa biosynthesis|inhibition of L-dopa biosynthetic process|inhibition of L-dopa formation|inhibition of L-dopa synthesis|negative regulation of L-dopa anabolism|negative regulation of L-dopa biosynthesis|negative regulation of L-dopa formation|negative regulation of L-dopa synthesis http://purl.obolibrary.org/obo/GO_1903196 GO:1903195 biolink:BiologicalProcess regulation of L-dopa biosynthetic process Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process. go.json regulation of L-dopa anabolism|regulation of L-dopa biosynthesis|regulation of L-dopa formation|regulation of L-dopa synthesis http://purl.obolibrary.org/obo/GO_1903195 GO:1903193 biolink:BiologicalProcess sesquarterpene biosynthetic process The chemical reactions and pathways resulting in the formation of sesquarterpene. go.json sesquarterpene anabolism|sesquarterpene biosynthesis|sesquarterpene formation|sesquarterpene synthesis http://purl.obolibrary.org/obo/GO_1903193 GO:1903192 biolink:BiologicalProcess sesquarterpene metabolic process The chemical reactions and pathways involving sesquarterpene. go.json sesquarterpene metabolism http://purl.obolibrary.org/obo/GO_1903192 GO:1903191 biolink:BiologicalProcess glyoxal biosynthetic process The chemical reactions and pathways resulting in the formation of glyoxal. go.json glyoxal anabolism|glyoxal biosynthesis|glyoxal formation|glyoxal synthesis http://purl.obolibrary.org/obo/GO_1903191 GO:1903190 biolink:BiologicalProcess glyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of glyoxal. go.json glyoxal breakdown|glyoxal catabolism|glyoxal degradation http://purl.obolibrary.org/obo/GO_1903190 GO:1903109 biolink:BiologicalProcess positive regulation of mitochondrial transcription Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion. go.json activation of mitochondrial transcription|activation of transcription from mitochondrial promoter|positive regulation of transcription from mitochondrial promoter|up regulation of mitochondrial transcription|up regulation of transcription from mitochondrial promoter|up-regulation of mitochondrial transcription|up-regulation of transcription from mitochondrial promoter|upregulation of mitochondrial transcription|upregulation of transcription from mitochondrial promoter http://purl.obolibrary.org/obo/GO_1903109 GO:1903108 biolink:BiologicalProcess regulation of mitochondrial transcription Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion. go.json regulation of transcription from mitochondrial promoter http://purl.obolibrary.org/obo/GO_1903108 GO:1903107 biolink:BiologicalProcess obsolete insulin receptor signaling pathway involved in dauer larval development OBSOLETE. Any insulin receptor signaling pathway that is involved in dauer larval development. go.json daf-2 receptor signaling pathway involved in dauer larval development|insulin receptor signalling pathway involved in dauer larval development True http://purl.obolibrary.org/obo/GO_1903107 GO:1903106 biolink:BiologicalProcess obsolete positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan OBSOLETE. Any process that activates or increases the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan. go.json activation of daf-2 receptor signaling pathway of determination of adult lifespan|activation of insulin receptor signaling pathway involved in determination of adult lifespan|activation of insulin receptor signaling pathway of determination of adult lifespan|activation of insulin receptor signalling pathway of determination of adult lifespan|positive regulation of daf-2 receptor signaling pathway of determination of adult lifespan|positive regulation of insulin receptor signaling pathway of determination of adult lifespan|positive regulation of insulin receptor signalling pathway of determination of adult lifespan|up regulation of daf-2 receptor signaling pathway of determination of adult lifespan|up regulation of insulin receptor signaling pathway involved in determination of adult lifespan|up regulation of insulin receptor signaling pathway of determination of adult lifespan|up regulation of insulin receptor signalling pathway of determination of adult lifespan|up-regulation of daf-2 receptor signaling pathway of determination of adult lifespan|up-regulation of insulin receptor signaling pathway involved in determination of adult lifespan|up-regulation of insulin receptor signaling pathway of determination of adult lifespan|up-regulation of insulin receptor signalling pathway of determination of adult lifespan|upregulation of daf-2 receptor signaling pathway of determination of adult lifespan|upregulation of insulin receptor signaling pathway involved in determination of adult lifespan|upregulation of insulin receptor signaling pathway of determination of adult lifespan|upregulation of insulin receptor signalling pathway of determination of adult lifespan True http://purl.obolibrary.org/obo/GO_1903106 GO:1903105 biolink:BiologicalProcess obsolete negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan. go.json down regulation of daf-2 receptor signaling pathway of determination of adult lifespan|down regulation of insulin receptor signaling pathway involved in determination of adult lifespan|down regulation of insulin receptor signaling pathway of determination of adult lifespan|down regulation of insulin receptor signalling pathway of determination of adult lifespan|down-regulation of daf-2 receptor signaling pathway of determination of adult lifespan|down-regulation of insulin receptor signaling pathway involved in determination of adult lifespan|down-regulation of insulin receptor signaling pathway of determination of adult lifespan|down-regulation of insulin receptor signalling pathway of determination of adult lifespan|downregulation of daf-2 receptor signaling pathway of determination of adult lifespan|downregulation of insulin receptor signaling pathway involved in determination of adult lifespan|downregulation of insulin receptor signaling pathway of determination of adult lifespan|downregulation of insulin receptor signalling pathway of determination of adult lifespan|inhibition of daf-2 receptor signaling pathway of determination of adult lifespan|inhibition of insulin receptor signaling pathway involved in determination of adult lifespan|inhibition of insulin receptor signaling pathway of determination of adult lifespan|inhibition of insulin receptor signalling pathway of determination of adult lifespan|negative regulation of daf-2 receptor signaling pathway of determination of adult lifespan|negative regulation of insulin receptor signaling pathway of determination of adult lifespan|negative regulation of insulin receptor signalling pathway of determination of adult lifespan True http://purl.obolibrary.org/obo/GO_1903105 GO:1903104 biolink:BiologicalProcess obsolete regulation of insulin receptor signaling pathway involved in determination of adult lifespan OBSOLETE. Any process that modulates the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan. go.json regulation of daf-2 receptor signaling pathway of determination of adult lifespan|regulation of insulin receptor signaling pathway of determination of adult lifespan|regulation of insulin receptor signalling pathway of determination of adult lifespan True http://purl.obolibrary.org/obo/GO_1903104 GO:1903103 biolink:CellularComponent potassium:proton antiporter complex A protein complex which is capable of potassium:proton antiporter activity. go.json http://purl.obolibrary.org/obo/GO_1903103 GO:1903102 biolink:BiologicalProcess 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. go.json 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate anabolism|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthesis|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate formation|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis http://purl.obolibrary.org/obo/GO_1903102 GO:1903101 biolink:BiologicalProcess 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. go.json 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate breakdown|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolism|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate degradation http://purl.obolibrary.org/obo/GO_1903101 GO:1903111 biolink:BiologicalProcess negative regulation of single-strand break repair via homologous recombination Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination. go.json down regulation of single-strand break repair via homologous recombination|down-regulation of single-strand break repair via homologous recombination|downregulation of single-strand break repair via homologous recombination|inhibition of single-strand break repair via homologous recombination http://purl.obolibrary.org/obo/GO_1903111 GO:1903110 biolink:BiologicalProcess regulation of single-strand break repair via homologous recombination Any process that modulates the frequency, rate or extent of single-strand break repair via homologous recombination. go.json http://purl.obolibrary.org/obo/GO_1903110 GO:1903119 biolink:BiologicalProcess protein localization to actin cytoskeleton A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. go.json protein localisation in actin cytoskeleton|protein localisation to actin cytoskeleton|protein localization in actin cytoskeleton http://purl.obolibrary.org/obo/GO_1903119 GO:1903118 biolink:BiologicalProcess obsolete urate homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of urate within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_1903118 GO:1903117 biolink:BiologicalProcess obsolete regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly OBSOLETE. Any process that modulates the frequency, rate or extent of actin filament organization involved in cytokinetic actomyosin contractile ring assembly. go.json regulation of actin filament organisation of constriction ring assembly|regulation of actin filament organisation of contractile ring assembly|regulation of actin filament organisation of cytokinesis, actomyosin contractile ring assembly|regulation of actin filament organisation of cytokinesis, actomyosin contractile ring formation|regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis|regulation of actin filament organisation of cytokinesis, actomyosin ring formation|regulation of actin filament organisation of cytokinesis, contractile ring assembly|regulation of actin filament organization of constriction ring assembly|regulation of actin filament organization of contractile ring assembly|regulation of actin filament organization of cytokinesis, actomyosin contractile ring assembly|regulation of actin filament organization of cytokinesis, actomyosin contractile ring formation|regulation of actin filament organization of cytokinesis, actomyosin ring biosynthesis|regulation of actin filament organization of cytokinesis, actomyosin ring formation|regulation of actin filament organization of cytokinesis, contractile ring assembly|regulation of regulation of actin filament localization of constriction ring assembly|regulation of regulation of actin filament localization of contractile ring assembly|regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly|regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation|regulation of regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis|regulation of regulation of actin filament localization of cytokinesis, actomyosin ring formation|regulation of regulation of actin filament localization of cytokinesis, contractile ring assembly True http://purl.obolibrary.org/obo/GO_1903117 GO:1903116 biolink:BiologicalProcess positive regulation of actin filament-based movement Any process that activates or increases the frequency, rate or extent of actin filament-based movement. go.json activation of actin filament-based movement|up regulation of actin filament-based movement|up-regulation of actin filament-based movement|upregulation of actin filament-based movement http://purl.obolibrary.org/obo/GO_1903116 GO:1903115 biolink:BiologicalProcess regulation of actin filament-based movement Any process that modulates the frequency, rate or extent of actin filament-based movement. go.json http://purl.obolibrary.org/obo/GO_1903115 GO:1903114 biolink:CellularComponent silver ion transmembrane transporter complex A protein complex which is capable of silver ion transmembrane transporter activity. go.json http://purl.obolibrary.org/obo/GO_1903114 GO:1903113 biolink:CellularComponent copper ion transmembrane transporter complex A protein complex which is capable of copper ion transmembrane transporter activity. go.json http://purl.obolibrary.org/obo/GO_1903113 GO:1903112 biolink:BiologicalProcess positive regulation of single-strand break repair via homologous recombination Any process that activates or increases the frequency, rate or extent of single-strand break repair via homologous recombination. go.json activation of single-strand break repair via homologous recombination|up regulation of single-strand break repair via homologous recombination|up-regulation of single-strand break repair via homologous recombination|upregulation of single-strand break repair via homologous recombination http://purl.obolibrary.org/obo/GO_1903112 GO:1903122 biolink:BiologicalProcess negative regulation of TRAIL-activated apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. go.json down regulation of TRAIL-activated apoptotic signaling pathway|down regulation of TRAIL-activated extrinsic apoptotic signaling pathway|down regulation of TRAIL-induced apoptotic signaling pathway|down regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|down-regulation of TRAIL-activated apoptotic signaling pathway|down-regulation of TRAIL-activated extrinsic apoptotic signaling pathway|down-regulation of TRAIL-induced apoptotic signaling pathway|down-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|downregulation of TRAIL-activated apoptotic signaling pathway|downregulation of TRAIL-activated extrinsic apoptotic signaling pathway|downregulation of TRAIL-induced apoptotic signaling pathway|downregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|inhibition of TRAIL-activated apoptotic signaling pathway|inhibition of TRAIL-activated extrinsic apoptotic signaling pathway|inhibition of TRAIL-induced apoptotic signaling pathway|inhibition of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|negative regulation of TRAIL-activated extrinsic apoptotic signaling pathway|negative regulation of TRAIL-induced apoptotic signaling pathway|negative regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_1903122 GO:1903121 biolink:BiologicalProcess regulation of TRAIL-activated apoptotic signaling pathway Any process that modulates the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. go.json regulation of TRAIL-activated extrinsic apoptotic signaling pathway|regulation of TRAIL-induced apoptotic signaling pathway|regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_1903121 GO:1903120 biolink:BiologicalProcess protein localization to actin filament bundle A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. go.json protein localisation in actin filament bundle|protein localisation to actin filament bundle|protein localization in actin filament bundle|protein localization to actin cable http://purl.obolibrary.org/obo/GO_1903120 GO:1903129 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903129 GO:1903128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903128 GO:1903127 biolink:BiologicalProcess positive regulation of centriole-centriole cohesion Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion. go.json activation of centriole-centriole cohesion|up regulation of centriole-centriole cohesion|up-regulation of centriole-centriole cohesion|upregulation of centriole-centriole cohesion http://purl.obolibrary.org/obo/GO_1903127 GO:1903126 biolink:BiologicalProcess negative regulation of centriole-centriole cohesion Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion. go.json down regulation of centriole-centriole cohesion|down-regulation of centriole-centriole cohesion|downregulation of centriole-centriole cohesion|inhibition of centriole-centriole cohesion http://purl.obolibrary.org/obo/GO_1903126 GO:1903125 biolink:BiologicalProcess negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation A peptidyl-threonine phosphorylation that results in negative regulation of thioredoxin peroxidase activity. go.json negative regulation of TPx activity by peptidyl-threonine phosphorylation|negative regulation of TrxPx activity by peptidyl-threonine phosphorylation|negative regulation of thiol peroxidase activity by peptidyl-threonine phosphorylation http://purl.obolibrary.org/obo/GO_1903125 gocheck_do_not_annotate GO:1903124 biolink:BiologicalProcess negative regulation of thioredoxin peroxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity. go.json down regulation of TPx activity|down regulation of TrxPx activity|down regulation of thiol peroxidase activity|down regulation of thioredoxin peroxidase activity|down-regulation of TPx activity|down-regulation of TrxPx activity|down-regulation of thiol peroxidase activity|down-regulation of thioredoxin peroxidase activity|downregulation of TPx activity|downregulation of TrxPx activity|downregulation of thiol peroxidase activity|downregulation of thioredoxin peroxidase activity|inhibition of TPx activity|inhibition of TrxPx activity|inhibition of thiol peroxidase activity|inhibition of thioredoxin peroxidase activity|negative regulation of TPx activity|negative regulation of TrxPx activity|negative regulation of thiol peroxidase activity http://purl.obolibrary.org/obo/GO_1903124 gocheck_do_not_annotate GO:1903123 biolink:BiologicalProcess regulation of thioredoxin peroxidase activity Any process that modulates the frequency, rate or extent of thioredoxin peroxidase activity. go.json regulation of TPx activity|regulation of TrxPx activity|regulation of thiol peroxidase activity http://purl.obolibrary.org/obo/GO_1903123 gocheck_do_not_annotate GO:1903133 biolink:BiologicalProcess negative regulation of tube lumen cavitation Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation. go.json inhibition of tube lumen cavitation http://purl.obolibrary.org/obo/GO_1903133 GO:1903132 biolink:BiologicalProcess regulation of tube lumen cavitation Any process that modulates the frequency, rate or extent of tube lumen cavitation. go.json http://purl.obolibrary.org/obo/GO_1903132 GO:1903131 biolink:BiologicalProcess mononuclear cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. go.json http://purl.obolibrary.org/obo/GO_1903131 GO:1903130 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1903130 GO:1903139 biolink:BiologicalProcess positive regulation of cell wall integrity MAPK cascade Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis. go.json activation of MAPK cascade involved in cell wall biogenesis|activation of MAPK cascade involved in cell wall organization or biogenesis|activation of MAPKKK cascade involved in cell wall biogenesis|activation of Mpk1 cascade|activation of PMK1-MAPK signal transduction pathway|activation of Pmk1 MAPK cell integrity signaling|activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|activation of Slt2 cascade|activation of cell integrity MAPK pathway|activation of cell wall biogenesis, MAPKKK cascade|positive regulation of MAPK cascade involved in cell wall biogenesis|positive regulation of MAPK cascade involved in cell wall organization or biogenesis|positive regulation of MAPKKK cascade involved in cell wall biogenesis|positive regulation of Mpk1 cascade|positive regulation of PMK1-MAPK signal transduction pathway|positive regulation of Pmk1 MAPK cell integrity signaling|positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|positive regulation of Slt2 cascade|positive regulation of cell integrity MAPK pathway|positive regulation of cell wall biogenesis, MAPKKK cascade|up regulation of MAPK cascade involved in cell wall biogenesis|up regulation of MAPK cascade involved in cell wall organization or biogenesis|up regulation of MAPKKK cascade involved in cell wall biogenesis|up regulation of Mpk1 cascade|up regulation of PMK1-MAPK signal transduction pathway|up regulation of Pmk1 MAPK cell integrity signaling|up regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|up regulation of Slt2 cascade|up regulation of cell integrity MAPK pathway|up regulation of cell wall biogenesis, MAPKKK cascade|up-regulation of MAPK cascade involved in cell wall biogenesis|up-regulation of MAPK cascade involved in cell wall organization or biogenesis|up-regulation of MAPKKK cascade involved in cell wall biogenesis|up-regulation of Mpk1 cascade|up-regulation of PMK1-MAPK signal transduction pathway|up-regulation of Pmk1 MAPK cell integrity signaling|up-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|up-regulation of Slt2 cascade|up-regulation of cell integrity MAPK pathway|up-regulation of cell wall biogenesis, MAPKKK cascade|upregulation of MAPK cascade involved in cell wall biogenesis|upregulation of MAPK cascade involved in cell wall organization or biogenesis|upregulation of MAPKKK cascade involved in cell wall biogenesis|upregulation of Mpk1 cascade|upregulation of PMK1-MAPK signal transduction pathway|upregulation of Pmk1 MAPK cell integrity signaling|upregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|upregulation of Slt2 cascade|upregulation of cell integrity MAPK pathway|upregulation of cell wall biogenesis, MAPKKK cascade http://purl.obolibrary.org/obo/GO_1903139 GO:1903138 biolink:BiologicalProcess negative regulation of cell wall integrity MAPK cascade Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis. go.json down regulation of MAPK cascade involved in cell wall biogenesis|down regulation of MAPK cascade involved in cell wall organization or biogenesis|down regulation of MAPKKK cascade involved in cell wall biogenesis|down regulation of Mpk1 cascade|down regulation of PMK1-MAPK signal transduction pathway|down regulation of Pmk1 MAPK cell integrity signaling|down regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|down regulation of Slt2 cascade|down regulation of cell integrity MAPK pathway|down regulation of cell wall biogenesis, MAPKKK cascade|down-regulation of MAPK cascade involved in cell wall biogenesis|down-regulation of MAPK cascade involved in cell wall organization or biogenesis|down-regulation of MAPKKK cascade involved in cell wall biogenesis|down-regulation of Mpk1 cascade|down-regulation of PMK1-MAPK signal transduction pathway|down-regulation of Pmk1 MAPK cell integrity signaling|down-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|down-regulation of Slt2 cascade|down-regulation of cell integrity MAPK pathway|down-regulation of cell wall biogenesis, MAPKKK cascade|downregulation of MAPK cascade involved in cell wall biogenesis|downregulation of MAPK cascade involved in cell wall organization or biogenesis|downregulation of MAPKKK cascade involved in cell wall biogenesis|downregulation of Mpk1 cascade|downregulation of PMK1-MAPK signal transduction pathway|downregulation of Pmk1 MAPK cell integrity signaling|downregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|downregulation of Slt2 cascade|downregulation of cell integrity MAPK pathway|downregulation of cell wall biogenesis, MAPKKK cascade|inhibition of MAPK cascade involved in cell wall biogenesis|inhibition of MAPK cascade involved in cell wall organization or biogenesis|inhibition of MAPKKK cascade involved in cell wall biogenesis|inhibition of Mpk1 cascade|inhibition of PMK1-MAPK signal transduction pathway|inhibition of Pmk1 MAPK cell integrity signaling|inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|inhibition of Slt2 cascade|inhibition of cell integrity MAPK pathway|inhibition of cell wall biogenesis, MAPKKK cascade|negative regulation of MAPK cascade involved in cell wall biogenesis|negative regulation of MAPK cascade involved in cell wall organization or biogenesis|negative regulation of MAPKKK cascade involved in cell wall biogenesis|negative regulation of Mpk1 cascade|negative regulation of PMK1-MAPK signal transduction pathway|negative regulation of Pmk1 MAPK cell integrity signaling|negative regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|negative regulation of Slt2 cascade|negative regulation of cell integrity MAPK pathway|negative regulation of cell wall biogenesis, MAPKKK cascade http://purl.obolibrary.org/obo/GO_1903138 GO:1903137 biolink:BiologicalProcess regulation of cell wall integrity MAPK cascade Any process that modulates the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis. go.json regulation of MAPK cascade involved in cell wall biogenesis|regulation of MAPK cascade involved in cell wall organization or biogenesis|regulation of MAPKKK cascade involved in cell wall biogenesis|regulation of Mpk1 cascade|regulation of PMK1-MAPK signal transduction pathway|regulation of Pmk1 MAPK cell integrity signaling|regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway|regulation of Slt2 cascade|regulation of cell integrity MAPK pathway|regulation of cell wall biogenesis, MAPKKK cascade http://purl.obolibrary.org/obo/GO_1903137 GO:1903136 biolink:MolecularActivity cuprous ion binding Binding to a cuprous ion, copper(1+). go.json Cu(+) binding|Cu(I) binding|copper(1+) binding http://purl.obolibrary.org/obo/GO_1903136 GO:1903135 biolink:MolecularActivity cupric ion binding Binding to a cupric ion, copper(2+). go.json Cu(2+) binding|Cu(II) binding|copper(2+)binding http://purl.obolibrary.org/obo/GO_1903135 GO:1903134 biolink:BiologicalProcess obsolete trehalose catabolic process involved in cellular response to stress OBSOLETE. Any trehalose catabolic process that is involved in cellular response to stress. go.json mycose catabolic process involved in cellular response to stress|mycose catabolism involved in cellular response to stress|mykose catabolic process involved in cellular response to stress|mykose catabolism involved in cellular response to stress|trehalose breakdown involved in cellular response to stress|trehalose catabolism involved in cellular response to stress|trehalose degradation involved in cellular response to stress True http://purl.obolibrary.org/obo/GO_1903134 GO:1903144 biolink:CellularComponent actomyosin contractile ring actin filament Any actin filament that is part of a actomyosin contractile ring. go.json actin filament of CAR|actin filament of actomyosin contractile ring|actin filament of actomyosin ring|actin filament of contractile actomyosin ring|actin filament of cytokinetic ring http://purl.obolibrary.org/obo/GO_1903144 GO:1903143 biolink:CellularComponent adrenomedullin receptor complex A transmembrane, G protein-coupled signaling receptor complex which is capable of adrenomedullin receptor activity. go.json adrenomedullin receptor AM1 complex|adrenomedullin receptor AM2 complex http://purl.obolibrary.org/obo/GO_1903143 GO:1903142 biolink:BiologicalProcess positive regulation of establishment of endothelial barrier Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier. go.json activation of establishment of endothelial barrier|up regulation of establishment of endothelial barrier|up-regulation of establishment of endothelial barrier|upregulation of establishment of endothelial barrier http://purl.obolibrary.org/obo/GO_1903142 GO:1903141 biolink:BiologicalProcess negative regulation of establishment of endothelial barrier Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier. go.json down regulation of establishment of endothelial barrier|down-regulation of establishment of endothelial barrier|downregulation of establishment of endothelial barrier|inhibition of establishment of endothelial barrier http://purl.obolibrary.org/obo/GO_1903141 GO:1903140 biolink:BiologicalProcess regulation of establishment of endothelial barrier Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. go.json http://purl.obolibrary.org/obo/GO_1903140 GO:1903149 biolink:MolecularActivity obsolete adenine transmembrane transporter activity involved in adenine import into cell OBSOLETE. Any adenine transmembrane transporter activity that is involved in adenine import into cell. go.json adenine transmembrane transporter activity involved in adenine import into cell True http://purl.obolibrary.org/obo/GO_1903149 GO:1903148 biolink:MolecularActivity obsolete uracil transmembrane transporter activity involved in uracil import into cell OBSOLETE. Any uracil transmembrane transporter activity that is involved in uracil import into cell. go.json uracil transmembrane transporter activity involved in uracil import into cell|uracil/uridine permease activity involved in uracil import into cell True http://purl.obolibrary.org/obo/GO_1903148 GO:1903147 biolink:BiologicalProcess negative regulation of autophagy of mitochondrion Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy. go.json down regulation of mitochondrial degradation|down regulation of mitochondrion degradation|down-regulation of mitochondrion degradation|down-regulation of mitophagy|downregulation of mitochondrion degradation|inhibition of mitochondrion degradation|inhibition of mitophagy http://purl.obolibrary.org/obo/GO_1903147 GO:1903146 biolink:BiologicalProcess regulation of autophagy of mitochondrion Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process. go.json regulation of mitochondrion degradation http://purl.obolibrary.org/obo/GO_1903146 GO:1903145 biolink:CellularComponent actin filament of cell cortex of cell tip Any actin filament that is part of a cell cortex of cell tip. go.json actin filament of cell cortex of cell end|microfilament of cell cortex of cell end|microfilament of cell cortex of cell tip http://purl.obolibrary.org/obo/GO_1903145 GO:1903155 biolink:MolecularActivity obsolete glutathione transmembrane transporter activity involved in glutathione import into cell OBSOLETE. Any glutathione transmembrane transporter activity that is involved in glutathione import into cell. go.json glutathione transmembrane transporter activity involved in glutathione import into cell|glutathione transmembrane transporter activity involved in glutathione uptake True http://purl.obolibrary.org/obo/GO_1903155 GO:1903154 biolink:MolecularActivity obsolete glucose transmembrane transporter activity involved in glucose import into cell OBSOLETE. Any glucose transmembrane transporter activity that is involved in glucose import into cell. go.json galactose/glucose (methylgalactoside) porter activity involved in glucose import into cell|glucose permease activity involved in glucose import into cell|glucose transmembrane transporter activity involved in glucose import into cell|lactose/glucose efflux transporter activity involved in glucose import into cell True http://purl.obolibrary.org/obo/GO_1903154 GO:1903153 biolink:MolecularActivity obsolete ferrous iron transmembrane transporter activity involved in ferrous iron import into cell OBSOLETE. Any ferrous iron transmembrane transporter activity that is involved in ferrous iron import into cell. go.json ferrous iron transmembrane transporter activity involved in ferrous ion import into cell|ferrous iron transmembrane transporter activity involved in ferrous iron import into cell True http://purl.obolibrary.org/obo/GO_1903153 GO:1903152 biolink:MolecularActivity obsolete copper ion transmembrane transporter activity involved in copper ion import into cell OBSOLETE. Any copper ion transmembrane transporter activity that is involved in copper ion import into cell. go.json copper ion transmembrane transporter activity involved in copper cation import into cell|copper ion transmembrane transporter activity involved in copper ion import into cell|intracellular copper ion transporter involved in copper cation import into cell|intracellular copper ion transporter involved in copper ion import into cell|plasma membrane copper transporter involved in copper cation import into cell|plasma membrane copper transporter involved in copper ion import into cell True http://purl.obolibrary.org/obo/GO_1903152 GO:1903151 biolink:MolecularActivity obsolete carbohydrate transmembrane transporter activity involved in carbohydrate import into cell OBSOLETE. Any carbohydrate transmembrane transporter activity that is involved in carbohydrate import into cell. go.json carbohydrate transmembrane transporter activity involved in carbohydrate import into cell|sugar transporter involved in carbohydrate import into cell True http://purl.obolibrary.org/obo/GO_1903151 GO:1903150 biolink:MolecularActivity obsolete calcium ion transmembrane transporter activity involved in calcium ion import into cell OBSOLETE. Any calcium ion transmembrane transporter activity that is involved in calcium ion import into cell. go.json calcium ion transmembrane transporter activity involved in calcium ion import into cell|calcium ion transmembrane transporter activity involved in calcium ion uptake into cell True http://purl.obolibrary.org/obo/GO_1903150 GO:1903159 biolink:MolecularActivity obsolete malate transmembrane transporter activity involved in malate import into cell OBSOLETE. Any malate transmembrane transporter activity that is involved in malate import into cell. go.json dicarboxylate (succinate/fumarate/malate) antiporter activity involved in malate import into cell|malate transmembrane transporter activity involved in malate import into cell True http://purl.obolibrary.org/obo/GO_1903159 GO:1903158 biolink:MolecularActivity obsolete L-glutamate transmembrane transporter activity involved in L-glutamate import into cell OBSOLETE. Any L-glutamate transmembrane transporter activity that is involved in L-glutamate import into cell. go.json L-glutamate transmembrane transporter activity involved in L-glutamate import into cell|glutamate/aspartate porter activity involved in L-glutamate import into cell|glutamate/aspartate:sodium symporter activity involved in L-glutamate import into cell True http://purl.obolibrary.org/obo/GO_1903158 GO:1903157 biolink:MolecularActivity obsolete iron ion transmembrane transporter activity involved in iron ion import into cell OBSOLETE. Any iron ion transmembrane transporter activity that is involved in iron ion import into cell. go.json iron ion transmembrane transporter activity involved in iron import into cell|iron ion transmembrane transporter activity involved in iron ion import into cell|iron transporter activity involved in iron import into cell|iron transporter activity involved in iron ion import into cell|multicopper ferroxidase iron transport mediator activity involved in iron import into cell|multicopper ferroxidase iron transport mediator activity involved in iron ion import into cell|transmembrane iron ion permease activity involved in iron import into cell|transmembrane iron ion permease activity involved in iron ion import into cell|transmembrane iron permease activity involved in iron import into cell|transmembrane iron permease activity involved in iron ion import into cell|zinc, iron permease activity involved in iron import into cell|zinc, iron permease activity involved in iron ion import into cell True http://purl.obolibrary.org/obo/GO_1903157 GO:1903156 biolink:MolecularActivity obsolete guanine transmembrane transporter activity involved in guanine import into cell OBSOLETE. Any guanine transmembrane transporter activity that is involved in guanine import into cell. go.json guanine transmembrane transporter activity involved in guanine import into cell True http://purl.obolibrary.org/obo/GO_1903156 GO:1903166 biolink:BiologicalProcess cellular response to polycyclic arene Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus. go.json http://purl.obolibrary.org/obo/GO_1903166 GO:1903165 biolink:BiologicalProcess response to polycyclic arene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus. go.json http://purl.obolibrary.org/obo/GO_1903165 GO:1903164 biolink:MolecularActivity obsolete succinate transmembrane transporter activity involved in succinate import into cell OBSOLETE. Any succinate transmembrane transporter activity that is involved in succinate import into cell. go.json dicarboxylate (succinate/fumarate/malate) antiporter activity involved in succinate import into cell|succinate transmembrane transporter activity involved in succinate import into cell True http://purl.obolibrary.org/obo/GO_1903164 GO:1903163 biolink:MolecularActivity obsolete sodium ion transmembrane transporter activity involved in sodium ion import into cell OBSOLETE. Any sodium ion transmembrane transporter activity that is involved in sodium ion import into cell. go.json sodium ion transmembrane transporter activity involved in sodium ion import into cell|sodium transporter activity involved in sodium ion import into cell True http://purl.obolibrary.org/obo/GO_1903163 GO:1903162 biolink:MolecularActivity obsolete serine transmembrane transporter activity involved in serine import into cell OBSOLETE. Any serine transmembrane transporter activity that is involved in serine import into cell. go.json serine transmembrane transporter activity involved in serine import into cell True http://purl.obolibrary.org/obo/GO_1903162 GO:1903161 biolink:MolecularActivity obsolete pantothenate transmembrane transporter activity involved in pantothenate import into cell OBSOLETE. Any pantothenate transmembrane transporter activity that is involved in pantothenate import into cell. go.json pantothenate transmembrane transporter activity involved in pantothenate import into cell|vitamin B5 transmembrane transporter activity involved in pantothenate import into cell True http://purl.obolibrary.org/obo/GO_1903161 GO:1903160 biolink:MolecularActivity obsolete nickel cation transmembrane transporter activity involved in nickel cation import into cell OBSOLETE. Any nickel cation transmembrane transporter activity that is involved in nickel cation import into cell. go.json nickel cation transmembrane transporter activity involved in nickel cation import into cell|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity involved in nickel cation import into cell True http://purl.obolibrary.org/obo/GO_1903160 GO:1903169 biolink:BiologicalProcess regulation of calcium ion transmembrane transport Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. go.json regulation of calcium ion membrane transport|regulation of transmembrane calcium transport http://purl.obolibrary.org/obo/GO_1903169 GO:1903168 biolink:BiologicalProcess positive regulation of pyrroline-5-carboxylate reductase activity Any process that activates or increases the frequency, rate or extent of pyrroline-5-carboxylate reductase activity. go.json activation of 1-pyrroline-5-carboxylate reductase activity|activation of L-proline oxidase activity|activation of L-proline-NAD(P)+ 5-oxidoreductase activity|activation of L-proline:NAD(P)+ 5-oxidoreductase activity|activation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity|activation of P5CR activity|activation of pyrroline-5-carboxylate reductase activity|positive regulation of 1-pyrroline-5-carboxylate reductase activity|positive regulation of L-proline oxidase activity|positive regulation of L-proline-NAD(P)+ 5-oxidoreductase activity|positive regulation of L-proline:NAD(P)+ 5-oxidoreductase activity|positive regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity|positive regulation of P5CR activity|up regulation of 1-pyrroline-5-carboxylate reductase activity|up regulation of L-proline oxidase activity|up regulation of L-proline-NAD(P)+ 5-oxidoreductase activity|up regulation of L-proline:NAD(P)+ 5-oxidoreductase activity|up regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity|up regulation of P5CR activity|up regulation of pyrroline-5-carboxylate reductase activity|up-regulation of 1-pyrroline-5-carboxylate reductase activity|up-regulation of L-proline oxidase activity|up-regulation of L-proline-NAD(P)+ 5-oxidoreductase activity|up-regulation of L-proline:NAD(P)+ 5-oxidoreductase activity|up-regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity|up-regulation of P5CR activity|up-regulation of pyrroline-5-carboxylate reductase activity|upregulation of 1-pyrroline-5-carboxylate reductase activity|upregulation of L-proline oxidase activity|upregulation of L-proline-NAD(P)+ 5-oxidoreductase activity|upregulation of L-proline:NAD(P)+ 5-oxidoreductase activity|upregulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity|upregulation of P5CR activity|upregulation of pyrroline-5-carboxylate reductase activity http://purl.obolibrary.org/obo/GO_1903168 gocheck_do_not_annotate GO:1903167 biolink:BiologicalProcess regulation of pyrroline-5-carboxylate reductase activity Any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity. go.json regulation of 1-pyrroline-5-carboxylate reductase activity|regulation of L-proline oxidase activity|regulation of L-proline-NAD(P)+ 5-oxidoreductase activity|regulation of L-proline:NAD(P)+ 5-oxidoreductase activity|regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity|regulation of P5CR activity http://purl.obolibrary.org/obo/GO_1903167 gocheck_do_not_annotate GO:1903177 biolink:BiologicalProcess negative regulation of tyrosine 3-monooxygenase activity Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity. go.json down regulation of L-tyrosine hydroxylase activity|down regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|down regulation of tyrosine 3-hydroxylase activity|down regulation of tyrosine 3-monooxygenase activity|down regulation of tyrosine hydroxylase activity|down-regulation of L-tyrosine hydroxylase activity|down-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|down-regulation of tyrosine 3-hydroxylase activity|down-regulation of tyrosine 3-monooxygenase activity|down-regulation of tyrosine hydroxylase activity|downregulation of L-tyrosine hydroxylase activity|downregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|downregulation of tyrosine 3-hydroxylase activity|downregulation of tyrosine 3-monooxygenase activity|downregulation of tyrosine hydroxylase activity|inhibition of L-tyrosine hydroxylase activity|inhibition of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|inhibition of tyrosine 3-hydroxylase activity|inhibition of tyrosine 3-monooxygenase activity|inhibition of tyrosine hydroxylase activity|negative regulation of L-tyrosine hydroxylase activity|negative regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|negative regulation of tyrosine 3-hydroxylase activity|negative regulation of tyrosine hydroxylase activity http://purl.obolibrary.org/obo/GO_1903177 gocheck_do_not_annotate GO:1903176 biolink:BiologicalProcess regulation of tyrosine 3-monooxygenase activity Any process that modulates the frequency, rate or extent of tyrosine 3-monooxygenase activity. go.json regulation of L-tyrosine hydroxylase activity|regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|regulation of tyrosine 3-hydroxylase activity|regulation of tyrosine hydroxylase activity http://purl.obolibrary.org/obo/GO_1903176 gocheck_do_not_annotate GO:1903175 biolink:BiologicalProcess fatty alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of fatty alcohol. go.json fatty alcohol anabolism|fatty alcohol biosynthesis|fatty alcohol formation|fatty alcohol synthesis http://purl.obolibrary.org/obo/GO_1903175 GO:1903174 biolink:BiologicalProcess fatty alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of fatty alcohol. go.json fatty alcohol breakdown|fatty alcohol catabolism|fatty alcohol degradation http://purl.obolibrary.org/obo/GO_1903174 GO:1903173 biolink:BiologicalProcess fatty alcohol metabolic process The chemical reactions and pathways involving fatty alcohol. go.json fatty alcohol metabolism http://purl.obolibrary.org/obo/GO_1903173 GO:1903172 biolink:BiologicalProcess obsolete cellular carbon dioxide homeostasis OBSOLETE. Any biological process involved in the maintenance of an internal steady state of carbon dioxide at the level of the cell. go.json True http://purl.obolibrary.org/obo/GO_1903172 GO:1903171 biolink:BiologicalProcess obsolete carbon dioxide homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of carbon dioxide within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_1903171 GO:1903170 biolink:BiologicalProcess negative regulation of calcium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. go.json down regulation of calcium ion membrane transport|down regulation of calcium ion transmembrane transport|down regulation of transmembrane calcium transport|down-regulation of calcium ion membrane transport|down-regulation of calcium ion transmembrane transport|down-regulation of transmembrane calcium transport|downregulation of calcium ion membrane transport|downregulation of calcium ion transmembrane transport|downregulation of transmembrane calcium transport|inhibition of calcium ion membrane transport|inhibition of calcium ion transmembrane transport|inhibition of transmembrane calcium transport|negative regulation of calcium ion membrane transport|negative regulation of transmembrane calcium transport http://purl.obolibrary.org/obo/GO_1903170 GO:1903179 biolink:BiologicalProcess regulation of dopamine biosynthetic process Any process that modulates the frequency, rate or extent of dopamine biosynthetic process. go.json regulation of dopamine anabolism|regulation of dopamine biosynthesis|regulation of dopamine formation|regulation of dopamine synthesis http://purl.obolibrary.org/obo/GO_1903179 GO:1903178 biolink:BiologicalProcess positive regulation of tyrosine 3-monooxygenase activity Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity. go.json activation of L-tyrosine hydroxylase activity|activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|activation of tyrosine 3-hydroxylase activity|activation of tyrosine 3-monooxygenase activity|activation of tyrosine hydroxylase activity|positive regulation of L-tyrosine hydroxylase activity|positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|positive regulation of TH activity|positive regulation of tyrosine 3-hydroxylase activity|positive regulation of tyrosine hydroxylase activity|stimulation of TH activity|up regulation of L-tyrosine hydroxylase activity|up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|up regulation of tyrosine 3-hydroxylase activity|up regulation of tyrosine 3-monooxygenase activity|up regulation of tyrosine hydroxylase activity|up-regulation of L-tyrosine hydroxylase activity|up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|up-regulation of tyrosine 3-hydroxylase activity|up-regulation of tyrosine 3-monooxygenase activity|up-regulation of tyrosine hydroxylase activity|upregulation of L-tyrosine hydroxylase activity|upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|upregulation of tyrosine 3-hydroxylase activity|upregulation of tyrosine 3-monooxygenase activity|upregulation of tyrosine hydroxylase activity http://purl.obolibrary.org/obo/GO_1903178 gocheck_do_not_annotate GO:1903188 biolink:BiologicalProcess positive regulation of vitellogenesis Any process that activates or increases the frequency, rate or extent of vitellogenesis. go.json activation of vitellogenesis|activation of yolk production|positive regulation of yolk production|up regulation of vitellogenesis|up regulation of yolk production|up-regulation of vitellogenesis|up-regulation of yolk production|upregulation of vitellogenesis|upregulation of yolk production http://purl.obolibrary.org/obo/GO_1903188 GO:1903187 biolink:BiologicalProcess negative regulation of vitellogenesis Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis. go.json down regulation of vitellogenesis|down regulation of yolk production|down-regulation of vitellogenesis|down-regulation of yolk production|downregulation of vitellogenesis|downregulation of yolk production|inhibition of vitellogenesis|inhibition of yolk production|negative regulation of yolk production http://purl.obolibrary.org/obo/GO_1903187 GO:1903186 biolink:BiologicalProcess regulation of vitellogenesis Any process that modulates the frequency, rate or extent of vitellogenesis. go.json regulation of yolk production http://purl.obolibrary.org/obo/GO_1903186 GO:1903185 biolink:BiologicalProcess L-dopa biosynthetic process The chemical reactions and pathways resulting in the formation of L-dopa. go.json L-dopa anabolism|L-dopa biosynthesis|L-dopa formation|L-dopa synthesis http://purl.obolibrary.org/obo/GO_1903185 GO:1903184 biolink:BiologicalProcess L-dopa metabolic process The chemical reactions and pathways involving L-dopa. go.json L-dopa metabolism http://purl.obolibrary.org/obo/GO_1903184 GO:1903183 biolink:BiologicalProcess negative regulation of SUMO transferase activity Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity. go.json down regulation of SMT3 conjugating enzyme|down regulation of SUMO conjugating enzyme activity|down regulation of SUMO ligase activity|down-regulation of SMT3 conjugating enzyme|down-regulation of SUMO conjugating enzyme activity|down-regulation of SUMO ligase activity|downregulation of SMT3 conjugating enzyme|downregulation of SUMO conjugating enzyme activity|downregulation of SUMO ligase activity|inhibition of SMT3 conjugating enzyme|inhibition of SUMO conjugating enzyme activity|inhibition of SUMO ligase activity|negative regulation of SMT3 conjugating enzyme|negative regulation of SUMO conjugating enzyme activity http://purl.obolibrary.org/obo/GO_1903183 gocheck_do_not_annotate GO:1903182 biolink:BiologicalProcess regulation of SUMO transferase activity Any process that modulates the frequency, rate or extent of SUMO ligase activity. go.json regulation of SMT3 conjugating enzyme|regulation of SUMO conjugating enzyme activity http://purl.obolibrary.org/obo/GO_1903182 gocheck_do_not_annotate GO:1903181 biolink:BiologicalProcess positive regulation of dopamine biosynthetic process Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process. go.json activation of dopamine anabolism|activation of dopamine biosynthesis|activation of dopamine biosynthetic process|activation of dopamine formation|activation of dopamine synthesis|positive regulation of dopamine anabolism|positive regulation of dopamine biosynthesis|positive regulation of dopamine formation|positive regulation of dopamine synthesis|up regulation of dopamine anabolism|up regulation of dopamine biosynthesis|up regulation of dopamine biosynthetic process|up regulation of dopamine formation|up regulation of dopamine synthesis|up-regulation of dopamine anabolism|up-regulation of dopamine biosynthesis|up-regulation of dopamine biosynthetic process|up-regulation of dopamine formation|up-regulation of dopamine synthesis|upregulation of dopamine anabolism|upregulation of dopamine biosynthesis|upregulation of dopamine biosynthetic process|upregulation of dopamine formation|upregulation of dopamine synthesis http://purl.obolibrary.org/obo/GO_1903181 GO:1903180 biolink:BiologicalProcess negative regulation of dopamine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process. go.json down regulation of dopamine anabolism|down regulation of dopamine biosynthesis|down regulation of dopamine biosynthetic process|down regulation of dopamine formation|down regulation of dopamine synthesis|down-regulation of dopamine anabolism|down-regulation of dopamine biosynthesis|down-regulation of dopamine biosynthetic process|down-regulation of dopamine formation|down-regulation of dopamine synthesis|downregulation of dopamine anabolism|downregulation of dopamine biosynthesis|downregulation of dopamine biosynthetic process|downregulation of dopamine formation|downregulation of dopamine synthesis|inhibition of dopamine anabolism|inhibition of dopamine biosynthesis|inhibition of dopamine biosynthetic process|inhibition of dopamine formation|inhibition of dopamine synthesis|negative regulation of dopamine anabolism|negative regulation of dopamine biosynthesis|negative regulation of dopamine formation|negative regulation of dopamine synthesis http://purl.obolibrary.org/obo/GO_1903180 GO:0004987 biolink:MolecularActivity obsolete kappa-opioid receptor activity OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins. Wikipedia:Kappa_Opioid_receptor go.json kappa-opioid receptor activity True http://purl.obolibrary.org/obo/GO_0004987 GO:0004986 biolink:MolecularActivity obsolete delta-opioid receptor activity OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands. Wikipedia:Delta_Opioid_receptor go.json delta-opioid receptor activity True http://purl.obolibrary.org/obo/GO_0004986 GO:0004989 biolink:MolecularActivity octopamine receptor activity Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist. go.json http://purl.obolibrary.org/obo/GO_0004989 GO:0004988 biolink:MolecularActivity obsolete mu-opioid receptor activity OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. Wikipedia:Mu_Opioid_receptor go.json mu-opioid receptor activity True http://purl.obolibrary.org/obo/GO_0004988 GO:0004983 biolink:MolecularActivity neuropeptide Y receptor activity Combining with neuropeptide Y to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004983 GO:0004982 biolink:MolecularActivity N-formyl peptide receptor activity Combining with an N-formyl peptide to initiate a change in cell activity. go.json Fmet-leu-phe receptor http://purl.obolibrary.org/obo/GO_0004982 GO:0004985 biolink:MolecularActivity G protein-coupled opioid receptor activity Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. go.json opioid receptor activity http://purl.obolibrary.org/obo/GO_0004985 GO:0004984 biolink:MolecularActivity olfactory receptor activity Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. go.json odorant receptor activity http://purl.obolibrary.org/obo/GO_0004984 GO:0004981 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004981 GO:0004980 biolink:MolecularActivity melanocyte-stimulating hormone receptor activity Combining with melanocyte-stimulating hormone to initiate a change in cell activity. go.json MSH receptor activity|MSHR activity|melanocyte stimulating hormone receptor activity|melanophore-stimulating hormone receptor activity http://purl.obolibrary.org/obo/GO_0004980 GO:0004998 biolink:MolecularActivity transferrin receptor activity Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates. go.json http://purl.obolibrary.org/obo/GO_0004998 GO:0004997 biolink:MolecularActivity thyrotropin-releasing hormone receptor activity Combining with thyrotropin-releasing hormone to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004997 GO:0004999 biolink:MolecularActivity vasoactive intestinal polypeptide receptor activity Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004999 GO:0004994 biolink:MolecularActivity somatostatin receptor activity Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). go.json GHIH receptor activity|SRIF receptor activity|SST receptor activity|growth hormone-inhibiting hormone receptor activity|somatotrophin release inhibiting factor receptor activity http://purl.obolibrary.org/obo/GO_0004994 GO:0004993 biolink:MolecularActivity G protein-coupled serotonin receptor activity Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. Wikipedia:5-HT_receptor go.json 5-HT receptor|5-hydroxytryptamine receptor|G protein coupled serotonin receptor activity|G-protein coupled serotonin receptor activity http://purl.obolibrary.org/obo/GO_0004993 GO:0004996 biolink:MolecularActivity thyroid-stimulating hormone receptor activity Combining with thyroid-stimulating hormone to initiate a change in cell activity. Wikipedia:Thyrotropin_receptor go.json TSH receptor activity|thyroid stimulating hormone receptor activity|thyrotropin receptor http://purl.obolibrary.org/obo/GO_0004996 GO:0004995 biolink:MolecularActivity tachykinin receptor activity Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. go.json http://purl.obolibrary.org/obo/GO_0004995 GO:0004990 biolink:MolecularActivity oxytocin receptor activity Combining with oxytocin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004990 GO:0004992 biolink:MolecularActivity platelet activating factor receptor activity Combining with platelet activating factor to initiate a change in cell activity. go.json PAF receptor activity http://purl.obolibrary.org/obo/GO_0004992 GO:0004991 biolink:MolecularActivity parathyroid hormone receptor activity Combining with parathyroid hormone to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004991 GO:0004965 biolink:MolecularActivity G protein-coupled GABA receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. Reactome:R-HSA-1013012|Reactome:R-HSA-1013013 go.json G-protein coupled GABA receptor activity|GABA-B receptor activity|metabotropic GABA receptor http://purl.obolibrary.org/obo/GO_0004965 GO:0004964 biolink:MolecularActivity luteinizing hormone receptor activity Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. go.json LH receptor|LHR|lutropin receptor|lutropin-choriogonadotropic hormone receptor http://purl.obolibrary.org/obo/GO_0004964 GO:0004967 biolink:MolecularActivity glucagon receptor activity Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json http://purl.obolibrary.org/obo/GO_0004967 GO:0004966 biolink:MolecularActivity galanin receptor activity Combining with galanin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004966 GO:0004961 biolink:MolecularActivity thromboxane A2 receptor activity Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. go.json TXA(2) receptor activity|TXA2 receptor activity http://purl.obolibrary.org/obo/GO_0004961 GO:0004960 biolink:MolecularActivity thromboxane receptor activity Combining with a thromboxane (TXA) to initiate a change in cell activity. go.json TXA receptor activity http://purl.obolibrary.org/obo/GO_0004960 GO:0004963 biolink:MolecularActivity follicle-stimulating hormone receptor activity Combining with follicle-stimulating hormone to initiate a change in cell activity. go.json FSH receptor activity|follicle stimulating hormone receptor activity http://purl.obolibrary.org/obo/GO_0004963 GO:0004962 biolink:MolecularActivity endothelin receptor activity Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json endothelin-A receptor activity|endothelin-B receptor activity http://purl.obolibrary.org/obo/GO_0004962 GO:0004969 biolink:MolecularActivity histamine receptor activity Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. go.json http://purl.obolibrary.org/obo/GO_0004969 GO:0004968 biolink:MolecularActivity gonadotropin-releasing hormone receptor activity Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. go.json GnRH receptor activity|gonadotrophin-releasing hormone receptor activity http://purl.obolibrary.org/obo/GO_0004968 GO:0004976 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004976 GO:0004975 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004975 GO:0004978 biolink:MolecularActivity corticotropin receptor activity Combining with corticotropin to initiate a change in cell activity. go.json ACTH receptor activity|adrenocorticotropic hormone receptor activity|adrenocorticotropin receptor activity http://purl.obolibrary.org/obo/GO_0004978 GO:0004977 biolink:MolecularActivity melanocortin receptor activity Combining with melanocortin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004977 GO:0004972 biolink:MolecularActivity NMDA glutamate receptor activity An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. Wikipedia:NMDA_receptor go.json N-methyl-D-aspartate selective glutamate receptor activity|NMDA receptor http://purl.obolibrary.org/obo/GO_0004972 GO:0004971 biolink:MolecularActivity AMPA glutamate receptor activity An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. go.json AMPA receptor activity|alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_0004971 GO:0004974 biolink:MolecularActivity leukotriene receptor activity Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. go.json http://purl.obolibrary.org/obo/GO_0004974 GO:0004973 biolink:MolecularActivity obsolete N-methyl-D-aspartate receptor-associated protein activity OBSOLETE. (Was not defined before being made obsolete). go.json N-methyl-D-aspartate receptor-associated protein activity True http://purl.obolibrary.org/obo/GO_0004973 GO:0004970 biolink:MolecularActivity ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0004970 GO:0004979 biolink:MolecularActivity beta-endorphin receptor activity Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). go.json mu-opioid receptor activity http://purl.obolibrary.org/obo/GO_0004979 GO:0004943 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004943 GO:0004942 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004942 GO:0004945 biolink:MolecularActivity angiotensin type II receptor activity An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. go.json http://purl.obolibrary.org/obo/GO_0004945 GO:0004944 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004944 GO:0004941 biolink:MolecularActivity beta2-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. go.json beta2 adrenoceptor http://purl.obolibrary.org/obo/GO_0004941 GO:0004940 biolink:MolecularActivity beta1-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. go.json beta1 adrenoceptor http://purl.obolibrary.org/obo/GO_0004940 GO:0004947 biolink:MolecularActivity bradykinin receptor activity Combining with bradykinin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004947 GO:0004946 biolink:MolecularActivity bombesin receptor activity Combining with bombesin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004946 GO:0004949 biolink:MolecularActivity cannabinoid receptor activity Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. go.json cannaboid receptor|endocannabinoid receptor activity http://purl.obolibrary.org/obo/GO_0004949 GO:0004948 biolink:MolecularActivity calcitonin receptor activity Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json http://purl.obolibrary.org/obo/GO_0004948 GO:0004954 biolink:MolecularActivity prostanoid receptor activity Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004954 GO:0004953 biolink:MolecularActivity icosanoid receptor activity Combining with an icosanoid to initiate a change in cell activity. go.json eicosanoid receptor activity http://purl.obolibrary.org/obo/GO_0004953 GO:0004956 biolink:MolecularActivity prostaglandin D receptor activity Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. go.json PGD receptor activity|PGD(2) receptor activity http://purl.obolibrary.org/obo/GO_0004956 GO:0004955 biolink:MolecularActivity prostaglandin receptor activity Combining with a prostaglandin (PG) to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004955 GO:0004950 biolink:MolecularActivity chemokine receptor activity Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. go.json http://purl.obolibrary.org/obo/GO_0004950 GO:0004952 biolink:MolecularActivity dopamine neurotransmitter receptor activity Combining with the neurotransmitter dopamine to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0004952 GO:0004951 biolink:MolecularActivity cholecystokinin receptor activity Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. go.json CCK receptor activity http://purl.obolibrary.org/obo/GO_0004951 GO:1903100 biolink:BiologicalProcess 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. go.json 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolism http://purl.obolibrary.org/obo/GO_1903100 GO:0004958 biolink:MolecularActivity prostaglandin F receptor activity Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. go.json PGF receptor activity|PGF(2-alpha) receptor activity http://purl.obolibrary.org/obo/GO_0004958 GO:0004957 biolink:MolecularActivity prostaglandin E receptor activity Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. go.json PGE receptor activity|PGE(2) receptor activity http://purl.obolibrary.org/obo/GO_0004957 GO:0004959 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004959 GO:1903069 biolink:BiologicalProcess regulation of ER-associated ubiquitin-dependent protein catabolic process Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. go.json regulation of ER-associated protein breakdown|regulation of ER-associated protein catabolic process|regulation of ER-associated protein catabolism|regulation of ER-associated protein degradation|regulation of ERAD|regulation of endoplasmic reticulum-associated protein catabolic process|regulation of endoplasmic reticulum-associated protein catabolism http://purl.obolibrary.org/obo/GO_1903069 GO:1903068 biolink:BiologicalProcess positive regulation of protein localization to cell tip Any process that activates or increases the frequency, rate or extent of protein localization to cell tip. go.json activation of protein localisation to cell tip|activation of protein localization to cell tip|positive regulation of protein localisation to cell tip|up regulation of protein localisation to cell tip|up regulation of protein localization to cell tip|up-regulation of protein localisation to cell tip|up-regulation of protein localization to cell tip|upregulation of protein localisation to cell tip|upregulation of protein localization to cell tip http://purl.obolibrary.org/obo/GO_1903068 GO:1903078 biolink:BiologicalProcess positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. go.json activation of protein localisation in plasma membrane|activation of protein localization in plasma membrane|activation of protein localization to plasma membrane|activation of protein targeting to plasma membrane|activation of protein-plasma membrane targeting|positive regulation of establishment of protein localisation in plasma membrane|positive regulation of establishment of protein localization to plasma membrane|positive regulation of protein localisation in plasma membrane|positive regulation of protein localization in plasma membrane|positive regulation of protein targeting to plasma membrane|positive regulation of protein-plasma membrane targeting|up regulation of protein localisation in plasma membrane|up regulation of protein localization in plasma membrane|up regulation of protein localization to plasma membrane|up regulation of protein targeting to plasma membrane|up regulation of protein-plasma membrane targeting|up-regulation of protein localisation in plasma membrane|up-regulation of protein localization in plasma membrane|up-regulation of protein localization to plasma membrane|up-regulation of protein targeting to plasma membrane|up-regulation of protein-plasma membrane targeting|upregulation of protein localisation in plasma membrane|upregulation of protein localization in plasma membrane|upregulation of protein localization to plasma membrane|upregulation of protein targeting to plasma membrane|upregulation of protein-plasma membrane targeting http://purl.obolibrary.org/obo/GO_1903078 GO:1903077 biolink:BiologicalProcess negative regulation of protein localization to plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. go.json down regulation of protein localisation in plasma membrane|down regulation of protein localization in plasma membrane|down regulation of protein localization to plasma membrane|down regulation of protein targeting to plasma membrane|down regulation of protein-plasma membrane targeting|down-regulation of protein localisation in plasma membrane|down-regulation of protein localization in plasma membrane|down-regulation of protein localization to plasma membrane|down-regulation of protein targeting to plasma membrane|down-regulation of protein-plasma membrane targeting|downregulation of protein localisation in plasma membrane|downregulation of protein localization in plasma membrane|downregulation of protein localization to plasma membrane|downregulation of protein targeting to plasma membrane|downregulation of protein-plasma membrane targeting|inhibition of protein localisation in plasma membrane|inhibition of protein localization in plasma membrane|inhibition of protein localization to plasma membrane|inhibition of protein targeting to plasma membrane|inhibition of protein-plasma membrane targeting|negative regulation of establishment of protein localisation in plasma membrane|negative regulation of establishment of protein localization in plasma membrane|negative regulation of establishment of protein localization to plasma membrane|negative regulation of protein localisation in plasma membrane|negative regulation of protein localization in plasma membrane|negative regulation of protein targeting to plasma membrane|negative regulation of protein-plasma membrane targeting http://purl.obolibrary.org/obo/GO_1903077 GO:1903076 biolink:BiologicalProcess regulation of protein localization to plasma membrane Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. go.json regulation of establishment of protein localisation in plasma membrane|regulation of establishment of protein localization in plasma membrane|regulation of establishment of protein localization to plasma membrane|regulation of protein localisation in plasma membrane|regulation of protein localization in plasma membrane|regulation of protein targeting to plasma membrane|regulation of protein-plasma membrane targeting http://purl.obolibrary.org/obo/GO_1903076 GO:1903075 biolink:BiologicalProcess pyridoxine import across plasma membrane The directed movement of pyridoxine from outside of a cell, across the plasma membrane and into the cytosol. go.json pyridoxine import into cell http://purl.obolibrary.org/obo/GO_1903075 GO:1903074 biolink:BiologicalProcess TRAIL death-inducing signaling complex assembly The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex. go.json TRAIL DISC assembly|TRAIL DISC formation|TRAIL death-inducing signaling complex formation|TRAIL death-inducing signalling complex assembly|TRAIL death-inducing signalling complex formation http://purl.obolibrary.org/obo/GO_1903074 GO:1903073 biolink:BiologicalProcess negative regulation of death-inducing signaling complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly. go.json down regulation of DD-mediated complex assembly|down regulation of DISC assembly|down regulation of DISC formation|down regulation of death domain-mediated complex assembly|down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|down regulation of death-inducing signaling complex assembly|down regulation of death-inducing signaling complex formation|down regulation of death-inducing signalling complex assembly|down-regulation of DD-mediated complex assembly|down-regulation of DISC assembly|down-regulation of DISC formation|down-regulation of death domain-mediated complex assembly|down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|down-regulation of death-inducing signaling complex assembly|down-regulation of death-inducing signaling complex formation|down-regulation of death-inducing signalling complex assembly|downregulation of DD-mediated complex assembly|downregulation of DISC assembly|downregulation of DISC formation|downregulation of death domain-mediated complex assembly|downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|downregulation of death-inducing signaling complex assembly|downregulation of death-inducing signaling complex formation|downregulation of death-inducing signalling complex assembly|inhibition of DD-mediated complex assembly|inhibition of DISC assembly|inhibition of DISC formation|inhibition of death domain-mediated complex assembly|inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|inhibition of death-inducing signaling complex assembly|inhibition of death-inducing signaling complex formation|inhibition of death-inducing signalling complex assembly|negative regulation of DD-mediated complex assembly|negative regulation of DISC assembly|negative regulation of DISC formation|negative regulation of death domain-mediated complex assembly|negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|negative regulation of death-inducing signaling complex formation|negative regulation of death-inducing signalling complex assembly http://purl.obolibrary.org/obo/GO_1903073 GO:1903072 biolink:BiologicalProcess regulation of death-inducing signaling complex assembly Any process that modulates the frequency, rate or extent of death-inducing signaling complex assembly. go.json regulation of DD-mediated complex assembly|regulation of DISC assembly|regulation of DISC formation|regulation of death domain-mediated complex assembly|regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|regulation of death-inducing signaling complex formation|regulation of death-inducing signalling complex assembly http://purl.obolibrary.org/obo/GO_1903072 GO:1903071 biolink:BiologicalProcess positive regulation of ER-associated ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. go.json activation of ER-associated protein breakdown|activation of ER-associated protein catabolic process|activation of ER-associated protein catabolism|activation of ER-associated protein degradation|activation of ER-associated ubiquitin-dependent protein catabolic process|activation of ERAD|activation of endoplasmic reticulum-associated protein catabolic process|activation of endoplasmic reticulum-associated protein catabolism|positive regulation of ER-associated protein breakdown|positive regulation of ER-associated protein catabolic process|positive regulation of ER-associated protein catabolism|positive regulation of ER-associated protein degradation|positive regulation of ERAD|positive regulation of endoplasmic reticulum-associated protein catabolic process|positive regulation of endoplasmic reticulum-associated protein catabolism|up regulation of ER-associated protein breakdown|up regulation of ER-associated protein catabolic process|up regulation of ER-associated protein catabolism|up regulation of ER-associated protein degradation|up regulation of ER-associated ubiquitin-dependent protein catabolic process|up regulation of ERAD|up regulation of endoplasmic reticulum-associated protein catabolic process|up regulation of endoplasmic reticulum-associated protein catabolism|up-regulation of ER-associated protein breakdown|up-regulation of ER-associated protein catabolic process|up-regulation of ER-associated protein catabolism|up-regulation of ER-associated protein degradation|up-regulation of ER-associated ubiquitin-dependent protein catabolic process|up-regulation of ERAD|up-regulation of endoplasmic reticulum-associated protein catabolic process|up-regulation of endoplasmic reticulum-associated protein catabolism|upregulation of ER-associated protein breakdown|upregulation of ER-associated protein catabolic process|upregulation of ER-associated protein catabolism|upregulation of ER-associated protein degradation|upregulation of ER-associated ubiquitin-dependent protein catabolic process|upregulation of ERAD|upregulation of endoplasmic reticulum-associated protein catabolic process|upregulation of endoplasmic reticulum-associated protein catabolism http://purl.obolibrary.org/obo/GO_1903071 GO:1903070 biolink:BiologicalProcess negative regulation of ER-associated ubiquitin-dependent protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. go.json down regulation of ER-associated protein breakdown|down regulation of ER-associated protein catabolic process|down regulation of ER-associated protein catabolism|down regulation of ER-associated protein degradation|down regulation of ER-associated ubiquitin-dependent protein catabolic process|down regulation of ERAD|down regulation of endoplasmic reticulum-associated protein catabolic process|down regulation of endoplasmic reticulum-associated protein catabolism|down-regulation of ER-associated protein breakdown|down-regulation of ER-associated protein catabolic process|down-regulation of ER-associated protein catabolism|down-regulation of ER-associated protein degradation|down-regulation of ER-associated ubiquitin-dependent protein catabolic process|down-regulation of ERAD|down-regulation of endoplasmic reticulum-associated protein catabolic process|down-regulation of endoplasmic reticulum-associated protein catabolism|downregulation of ER-associated protein breakdown|downregulation of ER-associated protein catabolic process|downregulation of ER-associated protein catabolism|downregulation of ER-associated protein degradation|downregulation of ER-associated ubiquitin-dependent protein catabolic process|downregulation of ERAD|downregulation of endoplasmic reticulum-associated protein catabolic process|downregulation of endoplasmic reticulum-associated protein catabolism|inhibition of ER-associated protein breakdown|inhibition of ER-associated protein catabolic process|inhibition of ER-associated protein catabolism|inhibition of ER-associated protein degradation|inhibition of ER-associated ubiquitin-dependent protein catabolic process|inhibition of ERAD|inhibition of endoplasmic reticulum-associated protein catabolic process|inhibition of endoplasmic reticulum-associated protein catabolism|negative regulation of ER-associated protein breakdown|negative regulation of ER-associated protein catabolic process|negative regulation of ER-associated protein catabolism|negative regulation of ER-associated protein degradation|negative regulation of ERAD|negative regulation of endoplasmic reticulum-associated protein catabolic process|negative regulation of endoplasmic reticulum-associated protein catabolism http://purl.obolibrary.org/obo/GO_1903070 GO:1903079 biolink:BiologicalProcess obsolete negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape OBSOLETE. Any negative regulation of protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape. go.json down regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|down regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|down-regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|down-regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|downregulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|downregulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|inhibition of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|inhibition of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|negative regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape True http://purl.obolibrary.org/obo/GO_1903079 GO:1903089 biolink:MolecularActivity 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other. go.json acadesine transporter activity http://purl.obolibrary.org/obo/GO_1903089 GO:1903088 biolink:BiologicalProcess 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903088 GO:1903087 biolink:BiologicalProcess mitotic spindle pole body duplication Any spindle pole body duplication that is involved in the mitotic cell cycle. go.json spindle pole body assembly involved in mitotic cell cycle|spindle pole body biogenesis involved in mitotic cell cycle|spindle pole body biosynthesis involved in mitotic cell cycle|spindle pole body duplication associated with nuclear envelope involved in mitotic cell cycle|spindle pole body duplication in cytoplasm involved in mitotic cell cycle|spindle pole body duplication involved in mitotic cell cycle|spindle pole body formation involved in mitotic cell cycle|spindle pole body replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1903087 GO:1903086 biolink:BiologicalProcess negative regulation of sinapate ester biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis. go.json down regulation of sinapate ester anabolism|down regulation of sinapate ester biosynthesis|down regulation of sinapate ester biosynthetic process|down regulation of sinapate ester formation|down regulation of sinapate ester synthesis|down-regulation of sinapate ester anabolism|down-regulation of sinapate ester biosynthesis|down-regulation of sinapate ester biosynthetic process|down-regulation of sinapate ester formation|down-regulation of sinapate ester synthesis|downregulation of sinapate ester anabolism|downregulation of sinapate ester biosynthesis|downregulation of sinapate ester biosynthetic process|downregulation of sinapate ester formation|downregulation of sinapate ester synthesis|inhibition of sinapate ester anabolism|inhibition of sinapate ester biosynthesis|inhibition of sinapate ester biosynthetic process|inhibition of sinapate ester formation|inhibition of sinapate ester synthesis|negative regulation of sinapate ester anabolism|negative regulation of sinapate ester biosynthesis|negative regulation of sinapate ester formation|negative regulation of sinapate ester synthesis http://purl.obolibrary.org/obo/GO_1903086 GO:1903085 biolink:BiologicalProcess regulation of sinapate ester biosynthetic process Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis. go.json regulation of sinapate ester anabolism|regulation of sinapate ester biosynthesis|regulation of sinapate ester formation|regulation of sinapate ester synthesis http://purl.obolibrary.org/obo/GO_1903085 GO:1903084 biolink:BiologicalProcess protein localization to condensed nuclear chromosome A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome. go.json protein localisation in condensed nuclear chromosome|protein localisation to condensed nuclear chromosome|protein localization in condensed nuclear chromosome http://purl.obolibrary.org/obo/GO_1903084 GO:1903083 biolink:BiologicalProcess protein localization to condensed chromosome A process in which a protein is transported to, or maintained in, a location within a condensed chromosome. go.json protein localisation in condensed chromosome|protein localisation to condensed chromosome|protein localization in condensed chromosome http://purl.obolibrary.org/obo/GO_1903083 GO:1903082 biolink:BiologicalProcess positive regulation of C-C chemokine receptor CCR7 signaling pathway Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway. go.json activation of C-C chemokine receptor CCR7 signaling pathway|activation of C-C chemokine receptor CCR7 signalling pathway|activation of CCR7 signaling pathway|positive regulation of C-C chemokine receptor CCR7 signalling pathway|positive regulation of CCR7 signaling pathway|up regulation of C-C chemokine receptor CCR7 signaling pathway|up regulation of C-C chemokine receptor CCR7 signalling pathway|up regulation of CCR7 signaling pathway|up-regulation of C-C chemokine receptor CCR7 signaling pathway|up-regulation of C-C chemokine receptor CCR7 signalling pathway|up-regulation of CCR7 signaling pathway|upregulation of C-C chemokine receptor CCR7 signaling pathway|upregulation of C-C chemokine receptor CCR7 signalling pathway|upregulation of CCR7 signaling pathway http://purl.obolibrary.org/obo/GO_1903082 GO:1903081 biolink:BiologicalProcess negative regulation of C-C chemokine receptor CCR7 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway. go.json down regulation of C-C chemokine receptor CCR7 signaling pathway|down regulation of C-C chemokine receptor CCR7 signalling pathway|down regulation of CCR7 signaling pathway|down-regulation of C-C chemokine receptor CCR7 signaling pathway|down-regulation of C-C chemokine receptor CCR7 signalling pathway|down-regulation of CCR7 signaling pathway|downregulation of C-C chemokine receptor CCR7 signaling pathway|downregulation of C-C chemokine receptor CCR7 signalling pathway|downregulation of CCR7 signaling pathway|inhibition of C-C chemokine receptor CCR7 signaling pathway|inhibition of C-C chemokine receptor CCR7 signalling pathway|inhibition of CCR7 signaling pathway|negative regulation of C-C chemokine receptor CCR7 signalling pathway|negative regulation of CCR7 signaling pathway http://purl.obolibrary.org/obo/GO_1903081 GO:1903080 biolink:BiologicalProcess regulation of C-C chemokine receptor CCR7 signaling pathway Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway. go.json regulation of C-C chemokine receptor CCR7 signalling pathway|regulation of CCR7 signaling pathway http://purl.obolibrary.org/obo/GO_1903080 GO:1903099 biolink:BiologicalProcess obsolete positive regulation of CENP-A containing nucleosome assembly OBSOLETE. Any process that activates or increases the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. go.json activation of CENP-A containing nucleosome assembly at centromere|activation of CENP-A deposition|activation of CENP-A loading|activation of CenH3-containing nucleosome assembly at centromere|activation of DNA replication-independent nucleosome assembly at centromere|activation of centromere specific nucleosome exchange|activation of centromere-specific histone exchange|activation of centromere-specific nucleosome assembly|activation of centromeric DNA replication-independent nucleosome assembly|positive regulation of CENP-A deposition|positive regulation of CENP-A loading|positive regulation of CenH3-containing nucleosome assembly at centromere|positive regulation of DNA replication-independent nucleosome assembly at centromere|positive regulation of centromere specific nucleosome exchange|positive regulation of centromere-specific histone exchange|positive regulation of centromere-specific nucleosome assembly|positive regulation of centromeric DNA replication-independent nucleosome assembly|up regulation of CENP-A containing nucleosome assembly at centromere|up regulation of CENP-A deposition|up regulation of CENP-A loading|up regulation of CenH3-containing nucleosome assembly at centromere|up regulation of DNA replication-independent nucleosome assembly at centromere|up regulation of centromere specific nucleosome exchange|up regulation of centromere-specific histone exchange|up regulation of centromere-specific nucleosome assembly|up regulation of centromeric DNA replication-independent nucleosome assembly|up-regulation of CENP-A containing nucleosome assembly at centromere|up-regulation of CENP-A deposition|up-regulation of CENP-A loading|up-regulation of CenH3-containing nucleosome assembly at centromere|up-regulation of DNA replication-independent nucleosome assembly at centromere|up-regulation of centromere specific nucleosome exchange|up-regulation of centromere-specific histone exchange|up-regulation of centromere-specific nucleosome assembly|up-regulation of centromeric DNA replication-independent nucleosome assembly|upregulation of CENP-A containing nucleosome assembly at centromere|upregulation of CENP-A deposition|upregulation of CENP-A loading|upregulation of CenH3-containing nucleosome assembly at centromere|upregulation of DNA replication-independent nucleosome assembly at centromere|upregulation of centromere specific nucleosome exchange|upregulation of centromere-specific histone exchange|upregulation of centromere-specific nucleosome assembly|upregulation of centromeric DNA replication-independent nucleosome assembly True http://purl.obolibrary.org/obo/GO_1903099 GO:1903098 biolink:BiologicalProcess obsolete negative regulation of CENP-A containing nucleosome assembly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. go.json down regulation of CENP-A containing nucleosome assembly at centromere|down regulation of CENP-A deposition|down regulation of CENP-A loading|down regulation of CenH3-containing nucleosome assembly at centromere|down regulation of DNA replication-independent nucleosome assembly at centromere|down regulation of centromere specific nucleosome exchange|down regulation of centromere-specific histone exchange|down regulation of centromere-specific nucleosome assembly|down regulation of centromeric DNA replication-independent nucleosome assembly|down-regulation of CENP-A containing nucleosome assembly at centromere|down-regulation of CENP-A deposition|down-regulation of CENP-A loading|down-regulation of CenH3-containing nucleosome assembly at centromere|down-regulation of DNA replication-independent nucleosome assembly at centromere|down-regulation of centromere specific nucleosome exchange|down-regulation of centromere-specific histone exchange|down-regulation of centromere-specific nucleosome assembly|down-regulation of centromeric DNA replication-independent nucleosome assembly|downregulation of CENP-A containing nucleosome assembly at centromere|downregulation of CENP-A deposition|downregulation of CENP-A loading|downregulation of CenH3-containing nucleosome assembly at centromere|downregulation of DNA replication-independent nucleosome assembly at centromere|downregulation of centromere specific nucleosome exchange|downregulation of centromere-specific histone exchange|downregulation of centromere-specific nucleosome assembly|downregulation of centromeric DNA replication-independent nucleosome assembly|inhibition of CENP-A containing nucleosome assembly at centromere|inhibition of CENP-A deposition|inhibition of CENP-A loading|inhibition of CenH3-containing nucleosome assembly at centromere|inhibition of DNA replication-independent nucleosome assembly at centromere|inhibition of centromere specific nucleosome exchange|inhibition of centromere-specific histone exchange|inhibition of centromere-specific nucleosome assembly|inhibition of centromeric DNA replication-independent nucleosome assembly|negative regulation of CENP-A deposition|negative regulation of CENP-A loading|negative regulation of CenH3-containing nucleosome assembly at centromere|negative regulation of DNA replication-independent nucleosome assembly at centromere|negative regulation of centromere specific nucleosome exchange|negative regulation of centromere-specific histone exchange|negative regulation of centromere-specific nucleosome assembly|negative regulation of centromeric DNA replication-independent nucleosome assembly True http://purl.obolibrary.org/obo/GO_1903098 GO:1903097 biolink:BiologicalProcess obsolete regulation of CENP-A containing nucleosome assembly OBSOLETE. Any process that modulates the rate, frequency or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. go.json regulation of CENP-A deposition|regulation of CENP-A loading|regulation of CenH3-containing nucleosome assembly at centromere|regulation of DNA replication-independent nucleosome assembly at centromere|regulation of centromere specific nucleosome exchange|regulation of centromere-specific histone exchange|regulation of centromere-specific nucleosome assembly|regulation of centromeric DNA replication-independent nucleosome assembly True http://purl.obolibrary.org/obo/GO_1903097 GO:1903096 biolink:BiologicalProcess protein localization to meiotic spindle midzone A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone. go.json protein localisation in meiotic spindle midzone|protein localisation to meiotic spindle midzone|protein localization in meiotic spindle midzone http://purl.obolibrary.org/obo/GO_1903096 GO:1903095 biolink:CellularComponent ribonuclease III complex A protein complex which is capable of ribonuclease III activity. go.json http://purl.obolibrary.org/obo/GO_1903095 GO:1903094 biolink:BiologicalProcess negative regulation of protein K48-linked deubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination. go.json down regulation of protein K48-linked deubiquitination|down-regulation of protein K48-linked deubiquitination|downregulation of protein K48-linked deubiquitination|inhibition of protein K48-linked deubiquitination http://purl.obolibrary.org/obo/GO_1903094 GO:1903093 biolink:BiologicalProcess regulation of protein K48-linked deubiquitination Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination. go.json http://purl.obolibrary.org/obo/GO_1903093 GO:1903092 biolink:BiologicalProcess pyridoxine transmembrane transport The process in which pyridoxine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903092 GO:1903091 biolink:BiologicalProcess pyridoxamine transmembrane transport The process in which pyridoxamine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903091 GO:1903090 biolink:BiologicalProcess pyridoxal transmembrane transport The process in which pyridoxal is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1903090 GO:1903001 biolink:BiologicalProcess negative regulation of lipid transport across blood-brain barrier Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood-brain barrier. go.json down regulation of lipid transport across blood brain barrier|down-regulation of lipid transport across blood brain barrier|downregulation of lipid transport across blood brain barrier|inhibition of lipid transport across blood brain barrier|negative regulation of lipid transport across blood brain barrier http://purl.obolibrary.org/obo/GO_1903001 GO:1903000 biolink:BiologicalProcess regulation of lipid transport across blood-brain barrier Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier. go.json regulation of lipid transport across blood brain barrier http://purl.obolibrary.org/obo/GO_1903000 GO:1903009 biolink:BiologicalProcess proteasome complex disassembly The disaggregation of a proteasome complex into its constituent components. go.json 26S proteasome disassembly|proteasome degradation|proteasome disassembly http://purl.obolibrary.org/obo/GO_1903009 GO:1903008 biolink:BiologicalProcess organelle disassembly The disaggregation of an organelle into its constituent components. go.json organelle degradation http://purl.obolibrary.org/obo/GO_1903008 GO:1903007 biolink:BiologicalProcess positive regulation of Lys63-specific deubiquitinase activity Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity. go.json activation of Lys63-specific deubiquitinase activity|up regulation of Lys63-specific deubiquitinase activity|up-regulation of Lys63-specific deubiquitinase activity|upregulation of Lys63-specific deubiquitinase activity http://purl.obolibrary.org/obo/GO_1903007 gocheck_do_not_annotate GO:1903006 biolink:BiologicalProcess positive regulation of protein K63-linked deubiquitination Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination. go.json activation of protein K63-linked deubiquitination|up regulation of protein K63-linked deubiquitination|up-regulation of protein K63-linked deubiquitination|upregulation of protein K63-linked deubiquitination http://purl.obolibrary.org/obo/GO_1903006 GO:1903005 biolink:BiologicalProcess negative regulation of protein K63-linked deubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination. go.json down regulation of protein K63-linked deubiquitination|down-regulation of protein K63-linked deubiquitination|downregulation of protein K63-linked deubiquitination|inhibition of protein K63-linked deubiquitination http://purl.obolibrary.org/obo/GO_1903005 GO:1903004 biolink:BiologicalProcess regulation of protein K63-linked deubiquitination Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination. go.json http://purl.obolibrary.org/obo/GO_1903004 GO:1903003 biolink:BiologicalProcess positive regulation of protein deubiquitination Any process that activates or increases the frequency, rate or extent of protein deubiquitination. go.json activation of deubiquitination|activation of protein deubiquitination|activation of protein deubiquitinylation|activation of protein deubiquitylation|positive regulation of deubiquitination|positive regulation of protein deubiquitinylation|positive regulation of protein deubiquitylation|up regulation of deubiquitination|up regulation of protein deubiquitination|up regulation of protein deubiquitinylation|up regulation of protein deubiquitylation|up-regulation of deubiquitination|up-regulation of protein deubiquitination|up-regulation of protein deubiquitinylation|up-regulation of protein deubiquitylation|upregulation of deubiquitination|upregulation of protein deubiquitination|upregulation of protein deubiquitinylation|upregulation of protein deubiquitylation http://purl.obolibrary.org/obo/GO_1903003 GO:1903002 biolink:BiologicalProcess positive regulation of lipid transport across blood-brain barrier Any process that activates or increases the frequency, rate or extent of lipid transport across blood-brain barrier. go.json activation of lipid transport across blood brain barrier|positive regulation of lipid transport across blood brain barrier|up regulation of lipid transport across blood brain barrier|up-regulation of lipid transport across blood brain barrier|upregulation of lipid transport across blood brain barrier http://purl.obolibrary.org/obo/GO_1903002 GO:1903012 biolink:BiologicalProcess positive regulation of bone development Any process that activates or increases the frequency, rate or extent of bone development. go.json activation of bone development|up regulation of bone development|up-regulation of bone development|upregulation of bone development http://purl.obolibrary.org/obo/GO_1903012 GO:1903011 biolink:BiologicalProcess negative regulation of bone development Any process that stops, prevents or reduces the frequency, rate or extent of bone development. go.json down regulation of bone development|down-regulation of bone development|downregulation of bone development|inhibition of bone development http://purl.obolibrary.org/obo/GO_1903011 GO:1903010 biolink:BiologicalProcess regulation of bone development Any process that modulates the frequency, rate or extent of bone development. go.json http://purl.obolibrary.org/obo/GO_1903010 GO:1903019 biolink:BiologicalProcess negative regulation of glycoprotein metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. go.json down regulation of glycoprotein metabolic process|down regulation of glycoprotein metabolism|down-regulation of glycoprotein metabolic process|down-regulation of glycoprotein metabolism|downregulation of glycoprotein metabolic process|downregulation of glycoprotein metabolism|inhibition of glycoprotein metabolic process|inhibition of glycoprotein metabolism|negative regulation of glycoprotein metabolism http://purl.obolibrary.org/obo/GO_1903019 GO:1903018 biolink:BiologicalProcess regulation of glycoprotein metabolic process Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. go.json regulation of glycoprotein metabolism http://purl.obolibrary.org/obo/GO_1903018 GO:1903017 biolink:BiologicalProcess positive regulation of exo-alpha-sialidase activity Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity. go.json activation of N-acylneuraminate glycohydrolase activity|activation of acetylneuraminidase activity|activation of acetylneuraminyl hydrolase activity|activation of alpha-neuraminidase activity|activation of exo-alpha-sialidase activity|activation of neuraminidase activity|activation of sialidase activity|positive regulation of N-acylneuraminate glycohydrolase activity|positive regulation of acetylneuraminidase activity|positive regulation of acetylneuraminyl hydrolase activity|positive regulation of alpha-neuraminidase activity|positive regulation of neuraminidase activity|positive regulation of sialidase activity|up regulation of N-acylneuraminate glycohydrolase activity|up regulation of acetylneuraminidase activity|up regulation of acetylneuraminyl hydrolase activity|up regulation of alpha-neuraminidase activity|up regulation of exo-alpha-sialidase activity|up regulation of neuraminidase activity|up regulation of sialidase activity|up-regulation of N-acylneuraminate glycohydrolase activity|up-regulation of acetylneuraminidase activity|up-regulation of acetylneuraminyl hydrolase activity|up-regulation of alpha-neuraminidase activity|up-regulation of exo-alpha-sialidase activity|up-regulation of neuraminidase activity|up-regulation of sialidase activity|upregulation of N-acylneuraminate glycohydrolase activity|upregulation of acetylneuraminidase activity|upregulation of acetylneuraminyl hydrolase activity|upregulation of alpha-neuraminidase activity|upregulation of exo-alpha-sialidase activity|upregulation of neuraminidase activity|upregulation of sialidase activity http://purl.obolibrary.org/obo/GO_1903017 gocheck_do_not_annotate GO:1903016 biolink:BiologicalProcess negative regulation of exo-alpha-sialidase activity Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity. go.json down regulation of N-acylneuraminate glycohydrolase activity|down regulation of acetylneuraminidase activity|down regulation of acetylneuraminyl hydrolase activity|down regulation of alpha-neuraminidase activity|down regulation of exo-alpha-sialidase activity|down regulation of neuraminidase activity|down regulation of sialidase activity|down-regulation of N-acylneuraminate glycohydrolase activity|down-regulation of acetylneuraminidase activity|down-regulation of acetylneuraminyl hydrolase activity|down-regulation of alpha-neuraminidase activity|down-regulation of exo-alpha-sialidase activity|down-regulation of neuraminidase activity|down-regulation of sialidase activity|downregulation of N-acylneuraminate glycohydrolase activity|downregulation of acetylneuraminidase activity|downregulation of acetylneuraminyl hydrolase activity|downregulation of alpha-neuraminidase activity|downregulation of exo-alpha-sialidase activity|downregulation of neuraminidase activity|downregulation of sialidase activity|inhibition of N-acylneuraminate glycohydrolase activity|inhibition of acetylneuraminidase activity|inhibition of acetylneuraminyl hydrolase activity|inhibition of alpha-neuraminidase activity|inhibition of exo-alpha-sialidase activity|inhibition of neuraminidase activity|inhibition of sialidase activity|negative regulation of N-acylneuraminate glycohydrolase activity|negative regulation of acetylneuraminidase activity|negative regulation of acetylneuraminyl hydrolase activity|negative regulation of alpha-neuraminidase activity|negative regulation of neuraminidase activity|negative regulation of sialidase activity http://purl.obolibrary.org/obo/GO_1903016 gocheck_do_not_annotate GO:1903015 biolink:BiologicalProcess regulation of exo-alpha-sialidase activity Any process that modulates the frequency, rate or extent of exo-alpha-sialidase activity. go.json regulation of N-acylneuraminate glycohydrolase activity|regulation of acetylneuraminidase activity|regulation of acetylneuraminyl hydrolase activity|regulation of alpha-neuraminidase activity|regulation of neuraminidase activity|regulation of sialidase activity http://purl.obolibrary.org/obo/GO_1903015 gocheck_do_not_annotate GO:1903014 biolink:BiologicalProcess cellular response to differentiation-inducing factor 1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus. go.json DIF-1|cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one|cellular response to DIF-1|cellular response to DIF1 http://purl.obolibrary.org/obo/GO_1903014 GO:1903013 biolink:BiologicalProcess response to differentiation-inducing factor 1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus. go.json DIF-1|response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one|response to DIF-1|response to DIF1 http://purl.obolibrary.org/obo/GO_1903013 GO:1903023 biolink:BiologicalProcess regulation of ascospore-type prospore membrane formation Any process that modulates the frequency, rate or extent of formation of an ascospore-type prospore membrane. go.json regulation of FSM assembly|regulation of FSM biosynthesis|regulation of FSM formation|regulation of ascospore-type prospore membrane assembly|regulation of forespore membrane biosynthesis|regulation of forespore membrane formation http://purl.obolibrary.org/obo/GO_1903023 GO:1903022 biolink:BiologicalProcess positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands Any process that activates or increases the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. go.json activation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands|up regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands|up-regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands|upregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands http://purl.obolibrary.org/obo/GO_1903022 gocheck_do_not_annotate GO:1903021 biolink:BiologicalProcess regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands Any process that modulates the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. go.json http://purl.obolibrary.org/obo/GO_1903021 gocheck_do_not_annotate GO:1903020 biolink:BiologicalProcess positive regulation of glycoprotein metabolic process Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. go.json activation of glycoprotein metabolic process|activation of glycoprotein metabolism|positive regulation of glycoprotein metabolism|up regulation of glycoprotein metabolic process|up regulation of glycoprotein metabolism|up-regulation of glycoprotein metabolic process|up-regulation of glycoprotein metabolism|upregulation of glycoprotein metabolic process|upregulation of glycoprotein metabolism http://purl.obolibrary.org/obo/GO_1903020 GO:1903028 biolink:BiologicalProcess positive regulation of opsonization Any process that activates or increases the frequency, rate or extent of opsonization. go.json activation of opsonization|up regulation of opsonization|up-regulation of opsonization|upregulation of opsonization http://purl.obolibrary.org/obo/GO_1903028 GO:1903027 biolink:BiologicalProcess regulation of opsonization Any process that modulates the frequency, rate or extent of opsonization. go.json http://purl.obolibrary.org/obo/GO_1903027 GO:1903026 biolink:BiologicalProcess negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. go.json down regulation of RNA polymerase II regulatory region sequence-specific DNA binding|down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding|downregulation of RNA polymerase II regulatory region sequence-specific DNA binding|inhibition of RNA polymerase II regulatory region sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_1903026 gocheck_do_not_annotate GO:1903025 biolink:BiologicalProcess regulation of RNA polymerase II regulatory region sequence-specific DNA binding Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. go.json http://purl.obolibrary.org/obo/GO_1903025 gocheck_do_not_annotate GO:1903024 biolink:BiologicalProcess positive regulation of ascospore-type prospore membrane formation Any process that activates or increases the frequency, rate or extent of formation of an ascospore-type prospore membrane. go.json activation of FSM assembly|activation of FSM biosynthesis|activation of FSM formation|activation of ascospore-type prospore membrane assembly|activation of forespore membrane biosynthesis|activation of forespore membrane formation|positive regulation of FSM assembly|positive regulation of FSM biosynthesis|positive regulation of FSM formation|positive regulation of ascospore-type prospore membrane assembly|positive regulation of forespore membrane biosynthesis|positive regulation of forespore membrane formation|up regulation of FSM assembly|up regulation of FSM biosynthesis|up regulation of FSM formation|up regulation of ascospore-type prospore membrane assembly|up regulation of forespore membrane biosynthesis|up regulation of forespore membrane formation|up-regulation of FSM assembly|up-regulation of FSM biosynthesis|up-regulation of FSM formation|up-regulation of ascospore-type prospore membrane assembly|up-regulation of forespore membrane biosynthesis|up-regulation of forespore membrane formation|upregulation of FSM assembly|upregulation of FSM biosynthesis|upregulation of FSM formation|upregulation of ascospore-type prospore membrane assembly|upregulation of forespore membrane biosynthesis|upregulation of forespore membrane formation http://purl.obolibrary.org/obo/GO_1903024 GO:1903034 biolink:BiologicalProcess regulation of response to wounding Any process that modulates the frequency, rate or extent of response to wounding. go.json regulation of physiological response to wounding http://purl.obolibrary.org/obo/GO_1903034 GO:1903033 biolink:BiologicalProcess positive regulation of microtubule plus-end binding Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding. go.json activation of microtubule plus-end binding|up regulation of microtubule plus-end binding|up-regulation of microtubule plus-end binding|upregulation of microtubule plus-end binding http://purl.obolibrary.org/obo/GO_1903033 gocheck_do_not_annotate GO:1903032 biolink:BiologicalProcess negative regulation of microtubule plus-end binding Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding. go.json down regulation of microtubule plus-end binding|down-regulation of microtubule plus-end binding|downregulation of microtubule plus-end binding|inhibition of microtubule plus-end binding http://purl.obolibrary.org/obo/GO_1903032 gocheck_do_not_annotate GO:1903031 biolink:BiologicalProcess regulation of microtubule plus-end binding Any process that modulates the frequency, rate or extent of microtubule plus-end binding. go.json http://purl.obolibrary.org/obo/GO_1903031 gocheck_do_not_annotate GO:1903039 biolink:BiologicalProcess positive regulation of leukocyte cell-cell adhesion Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. go.json activation of leukocyte adhesion|activation of leukocyte cell adhesion|activation of leukocyte cell-cell adhesion|positive regulation of leukocyte adhesion|positive regulation of leukocyte cell adhesion|up regulation of leukocyte adhesion|up regulation of leukocyte cell adhesion|up regulation of leukocyte cell-cell adhesion|up-regulation of leukocyte adhesion|up-regulation of leukocyte cell adhesion|up-regulation of leukocyte cell-cell adhesion|upregulation of leukocyte adhesion|upregulation of leukocyte cell adhesion|upregulation of leukocyte cell-cell adhesion http://purl.obolibrary.org/obo/GO_1903039 GO:1903038 biolink:BiologicalProcess negative regulation of leukocyte cell-cell adhesion Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. go.json down regulation of leukocyte adhesion|down regulation of leukocyte cell adhesion|down regulation of leukocyte cell-cell adhesion|down-regulation of leukocyte adhesion|down-regulation of leukocyte cell adhesion|down-regulation of leukocyte cell-cell adhesion|downregulation of leukocyte adhesion|downregulation of leukocyte cell adhesion|downregulation of leukocyte cell-cell adhesion|inhibition of leukocyte adhesion|inhibition of leukocyte cell adhesion|inhibition of leukocyte cell-cell adhesion|negative regulation of leukocyte adhesion|negative regulation of leukocyte cell adhesion http://purl.obolibrary.org/obo/GO_1903038 GO:1903037 biolink:BiologicalProcess regulation of leukocyte cell-cell adhesion Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. go.json regulation of leukocyte adhesion|regulation of leukocyte cell adhesion http://purl.obolibrary.org/obo/GO_1903037 GO:1903036 biolink:BiologicalProcess positive regulation of response to wounding Any process that activates or increases the frequency, rate or extent of response to wounding. go.json activation of physiological response to wounding|activation of response to wounding|positive regulation of physiological response to wounding|up regulation of physiological response to wounding|up regulation of response to wounding|up-regulation of physiological response to wounding|up-regulation of response to wounding|upregulation of physiological response to wounding|upregulation of response to wounding http://purl.obolibrary.org/obo/GO_1903036 GO:1903035 biolink:BiologicalProcess negative regulation of response to wounding Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. go.json down regulation of physiological response to wounding|down regulation of response to wounding|down-regulation of physiological response to wounding|down-regulation of response to wounding|downregulation of physiological response to wounding|downregulation of response to wounding|inhibition of physiological response to wounding|inhibition of response to wounding|negative regulation of physiological response to wounding http://purl.obolibrary.org/obo/GO_1903035 GO:1903045 biolink:BiologicalProcess neural crest cell migration involved in sympathetic nervous system development Any neural crest cell migration that is involved in sympathetic nervous system development. go.json http://purl.obolibrary.org/obo/GO_1903045 GO:1903044 biolink:BiologicalProcess protein localization to membrane raft A process in which a protein is transported to, or maintained in, a location within a membrane raft. go.json protein localisation in membrane raft|protein localisation to membrane raft|protein localization in membrane raft http://purl.obolibrary.org/obo/GO_1903044 GO:1903043 biolink:BiologicalProcess positive regulation of chondrocyte hypertrophy Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy. go.json activation of chondrocyte hypertrophy|up regulation of chondrocyte hypertrophy|up-regulation of chondrocyte hypertrophy|upregulation of chondrocyte hypertrophy http://purl.obolibrary.org/obo/GO_1903043 GO:1903042 biolink:BiologicalProcess negative regulation of chondrocyte hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy. go.json down regulation of chondrocyte hypertrophy|down-regulation of chondrocyte hypertrophy|downregulation of chondrocyte hypertrophy|inhibition of chondrocyte hypertrophy http://purl.obolibrary.org/obo/GO_1903042 GO:1903041 biolink:BiologicalProcess regulation of chondrocyte hypertrophy Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy. go.json http://purl.obolibrary.org/obo/GO_1903041 GO:1903040 biolink:BiologicalProcess exon-exon junction complex assembly The aggregation, arrangement and bonding together of a set of components to form an exon-exon junction complex. go.json EJC assembly|EJC formation|exon-exon junction complex formation http://purl.obolibrary.org/obo/GO_1903040 GO:1903049 biolink:BiologicalProcess negative regulation of acetylcholine-gated cation channel activity Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine-gated cation channel activity. go.json down regulation of acetylcholine-gated cation channel activity|down-regulation of acetylcholine-gated cation channel activity|downregulation of acetylcholine-gated cation channel activity|inhibition of acetylcholine-gated cation channel activity http://purl.obolibrary.org/obo/GO_1903049 gocheck_do_not_annotate GO:1903048 biolink:BiologicalProcess regulation of acetylcholine-gated cation channel activity Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity. go.json http://purl.obolibrary.org/obo/GO_1903048 gocheck_do_not_annotate GO:1903047 biolink:BiologicalProcess mitotic cell cycle process A process that is part of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_1903047 gocheck_do_not_annotate GO:1903046 biolink:BiologicalProcess meiotic cell cycle process A process that is part of the meiotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_1903046 gocheck_do_not_annotate|goslim_pombe GO:1903056 biolink:BiologicalProcess regulation of melanosome organization Any process that modulates the frequency, rate or extent of melanosome organization. go.json regulation of melanosome organisation|regulation of melanosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1903056 GO:1903055 biolink:BiologicalProcess positive regulation of extracellular matrix organization Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. go.json activation of extracellular matrix organisation|activation of extracellular matrix organization|activation of extracellular matrix organization and biogenesis|positive regulation of extracellular matrix organisation|positive regulation of extracellular matrix organization and biogenesis|up regulation of extracellular matrix organisation|up regulation of extracellular matrix organization|up regulation of extracellular matrix organization and biogenesis|up-regulation of extracellular matrix organisation|up-regulation of extracellular matrix organization|up-regulation of extracellular matrix organization and biogenesis|upregulation of extracellular matrix organisation|upregulation of extracellular matrix organization|upregulation of extracellular matrix organization and biogenesis http://purl.obolibrary.org/obo/GO_1903055 GO:1903054 biolink:BiologicalProcess negative regulation of extracellular matrix organization Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. go.json down regulation of extracellular matrix organisation|down regulation of extracellular matrix organization|down regulation of extracellular matrix organization and biogenesis|down-regulation of extracellular matrix organisation|down-regulation of extracellular matrix organization|down-regulation of extracellular matrix organization and biogenesis|downregulation of extracellular matrix organisation|downregulation of extracellular matrix organization|downregulation of extracellular matrix organization and biogenesis|inhibition of extracellular matrix organisation|inhibition of extracellular matrix organization|inhibition of extracellular matrix organization and biogenesis|negative regulation of extracellular matrix organisation|negative regulation of extracellular matrix organization and biogenesis http://purl.obolibrary.org/obo/GO_1903054 GO:1903053 biolink:BiologicalProcess regulation of extracellular matrix organization Any process that modulates the frequency, rate or extent of extracellular matrix organization. go.json regulation of extracellular matrix organisation|regulation of extracellular matrix organization and biogenesis http://purl.obolibrary.org/obo/GO_1903053 GO:1903052 biolink:BiologicalProcess positive regulation of proteolysis involved in protein catabolic process Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process. go.json activation of peptidolysis during cellular protein catabolic process|activation of peptidolysis during cellular protein catabolism|activation of peptidolysis involved in cellular protein catabolic process|activation of peptidolysis involved in cellular protein catabolism|activation of proteolysis during cellular protein catabolic process|activation of proteolysis during cellular protein catabolism|activation of proteolysis involved in cellular protein catabolic process|positive regulation of peptidolysis during cellular protein catabolic process|positive regulation of peptidolysis during cellular protein catabolism|positive regulation of peptidolysis involved in cellular protein catabolic process|positive regulation of peptidolysis involved in cellular protein catabolism|positive regulation of proteolysis during cellular protein catabolic process|positive regulation of proteolysis during cellular protein catabolism|positive regulation of proteolysis involved in cellular protein catabolic process|up regulation of peptidolysis during cellular protein catabolic process|up regulation of peptidolysis during cellular protein catabolism|up regulation of peptidolysis involved in cellular protein catabolic process|up regulation of peptidolysis involved in cellular protein catabolism|up regulation of proteolysis during cellular protein catabolic process|up regulation of proteolysis during cellular protein catabolism|up regulation of proteolysis involved in cellular protein catabolic process|up-regulation of peptidolysis during cellular protein catabolic process|up-regulation of peptidolysis during cellular protein catabolism|up-regulation of peptidolysis involved in cellular protein catabolic process|up-regulation of peptidolysis involved in cellular protein catabolism|up-regulation of proteolysis during cellular protein catabolic process|up-regulation of proteolysis during cellular protein catabolism|up-regulation of proteolysis involved in cellular protein catabolic process|upregulation of peptidolysis during cellular protein catabolic process|upregulation of peptidolysis during cellular protein catabolism|upregulation of peptidolysis involved in cellular protein catabolic process|upregulation of peptidolysis involved in cellular protein catabolism|upregulation of proteolysis during cellular protein catabolic process|upregulation of proteolysis during cellular protein catabolism|upregulation of proteolysis involved in cellular protein catabolic process http://purl.obolibrary.org/obo/GO_1903052 GO:1903051 biolink:BiologicalProcess negative regulation of proteolysis involved in protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process. go.json down regulation of peptidolysis during cellular protein catabolic process|down regulation of peptidolysis during cellular protein catabolism|down regulation of peptidolysis involved in cellular protein catabolic process|down regulation of peptidolysis involved in cellular protein catabolism|down regulation of proteolysis during cellular protein catabolic process|down regulation of proteolysis during cellular protein catabolism|down regulation of proteolysis involved in cellular protein catabolic process|down-regulation of peptidolysis during cellular protein catabolic process|down-regulation of peptidolysis during cellular protein catabolism|down-regulation of peptidolysis involved in cellular protein catabolic process|down-regulation of peptidolysis involved in cellular protein catabolism|down-regulation of proteolysis during cellular protein catabolic process|down-regulation of proteolysis during cellular protein catabolism|down-regulation of proteolysis involved in cellular protein catabolic process|downregulation of peptidolysis during cellular protein catabolic process|downregulation of peptidolysis during cellular protein catabolism|downregulation of peptidolysis involved in cellular protein catabolic process|downregulation of peptidolysis involved in cellular protein catabolism|downregulation of proteolysis during cellular protein catabolic process|downregulation of proteolysis during cellular protein catabolism|downregulation of proteolysis involved in cellular protein catabolic process|inhibition of peptidolysis during cellular protein catabolic process|inhibition of peptidolysis during cellular protein catabolism|inhibition of peptidolysis involved in cellular protein catabolic process|inhibition of peptidolysis involved in cellular protein catabolism|inhibition of proteolysis during cellular protein catabolic process|inhibition of proteolysis during cellular protein catabolism|inhibition of proteolysis involved in cellular protein catabolic process|negative regulation of peptidolysis during cellular protein catabolic process|negative regulation of peptidolysis during cellular protein catabolism|negative regulation of peptidolysis involved in cellular protein catabolic process|negative regulation of peptidolysis involved in cellular protein catabolism|negative regulation of proteolysis during cellular protein catabolic process|negative regulation of proteolysis during cellular protein catabolism|negative regulation of proteolysis involved in cellular protein catabolic process http://purl.obolibrary.org/obo/GO_1903051 GO:1903050 biolink:BiologicalProcess regulation of proteolysis involved in protein catabolic process Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process. go.json regulation of peptidolysis during cellular protein catabolic process|regulation of peptidolysis during cellular protein catabolism|regulation of peptidolysis involved in cellular protein catabolic process|regulation of peptidolysis involved in cellular protein catabolism|regulation of proteolysis during cellular protein catabolic process|regulation of proteolysis during cellular protein catabolism|regulation of proteolysis involved in cellular protein catabolic process http://purl.obolibrary.org/obo/GO_1903050 GO:1903059 biolink:BiologicalProcess regulation of protein lipidation Any process that modulates the frequency, rate or extent of protein lipidation. go.json regulation of lipid:protein modification|regulation of protein amino acid lipidation http://purl.obolibrary.org/obo/GO_1903059 GO:1903058 biolink:BiologicalProcess positive regulation of melanosome organization Any process that activates or increases the frequency, rate or extent of melanosome organization. go.json activation of melanosome organisation|activation of melanosome organization|activation of melanosome organization and biogenesis|positive regulation of melanosome organisation|positive regulation of melanosome organization and biogenesis|up regulation of melanosome organisation|up regulation of melanosome organization|up regulation of melanosome organization and biogenesis|up-regulation of melanosome organisation|up-regulation of melanosome organization|up-regulation of melanosome organization and biogenesis|upregulation of melanosome organisation|upregulation of melanosome organization|upregulation of melanosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1903058 GO:1903057 biolink:BiologicalProcess negative regulation of melanosome organization Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization. go.json down regulation of melanosome organisation|down regulation of melanosome organization|down regulation of melanosome organization and biogenesis|down-regulation of melanosome organisation|down-regulation of melanosome organization|down-regulation of melanosome organization and biogenesis|downregulation of melanosome organisation|downregulation of melanosome organization|downregulation of melanosome organization and biogenesis|inhibition of melanosome organisation|inhibition of melanosome organization|inhibition of melanosome organization and biogenesis|negative regulation of melanosome organisation|negative regulation of melanosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1903057 GO:1903067 biolink:BiologicalProcess negative regulation of protein localization to cell tip Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell tip. go.json down regulation of protein localisation to cell tip|down regulation of protein localization to cell tip|down-regulation of protein localisation to cell tip|down-regulation of protein localization to cell tip|downregulation of protein localisation to cell tip|downregulation of protein localization to cell tip|inhibition of protein localisation to cell tip|inhibition of protein localization to cell tip|negative regulation of protein localisation to cell tip http://purl.obolibrary.org/obo/GO_1903067 GO:1903066 biolink:BiologicalProcess regulation of protein localization to cell tip Any process that modulates the frequency, rate or extent of protein localization to cell tip. go.json regulation of protein localisation to cell tip http://purl.obolibrary.org/obo/GO_1903066 GO:1903065 biolink:BiologicalProcess obsolete protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape OBSOLETE. Any protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape. go.json protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape|protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape True http://purl.obolibrary.org/obo/GO_1903065 GO:1903064 biolink:BiologicalProcess positive regulation of reverse cholesterol transport Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport. go.json activation of reverse cholesterol transport|up regulation of reverse cholesterol transport|up-regulation of reverse cholesterol transport|upregulation of reverse cholesterol transport http://purl.obolibrary.org/obo/GO_1903064 GO:1903063 biolink:BiologicalProcess negative regulation of reverse cholesterol transport Any process that stops, prevents or reduces the frequency, rate or extent of reverse cholesterol transport. go.json down regulation of reverse cholesterol transport|down-regulation of reverse cholesterol transport|downregulation of reverse cholesterol transport|inhibition of reverse cholesterol transport http://purl.obolibrary.org/obo/GO_1903063 GO:1903062 biolink:BiologicalProcess regulation of reverse cholesterol transport Any process that modulates the frequency, rate or extent of reverse cholesterol transport. go.json http://purl.obolibrary.org/obo/GO_1903062 GO:1903061 biolink:BiologicalProcess positive regulation of protein lipidation Any process that activates or increases the frequency, rate or extent of protein lipidation. go.json activation of lipid:protein modification|activation of protein amino acid lipidation|activation of protein lipidation|positive regulation of lipid:protein modification|positive regulation of protein amino acid lipidation|up regulation of lipid:protein modification|up regulation of protein amino acid lipidation|up regulation of protein lipidation|up-regulation of lipid:protein modification|up-regulation of protein amino acid lipidation|up-regulation of protein lipidation|upregulation of lipid:protein modification|upregulation of protein amino acid lipidation|upregulation of protein lipidation http://purl.obolibrary.org/obo/GO_1903061 GO:1903060 biolink:BiologicalProcess negative regulation of protein lipidation Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation. go.json down regulation of lipid:protein modification|down regulation of protein amino acid lipidation|down regulation of protein lipidation|down-regulation of lipid:protein modification|down-regulation of protein amino acid lipidation|down-regulation of protein lipidation|downregulation of lipid:protein modification|downregulation of protein amino acid lipidation|downregulation of protein lipidation|inhibition of lipid:protein modification|inhibition of protein amino acid lipidation|inhibition of protein lipidation|negative regulation of lipid:protein modification|negative regulation of protein amino acid lipidation http://purl.obolibrary.org/obo/GO_1903060 GO:0033769 biolink:MolecularActivity glyceollin synthase activity Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O. EC:1.14.14.135 go.json dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity http://purl.obolibrary.org/obo/GO_0033769 GO:0033768 biolink:CellularComponent SUMO-targeted ubiquitin ligase complex A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes. go.json http://purl.obolibrary.org/obo/GO_0033768 GO:0033767 biolink:MolecularActivity 4-hydroxyacetophenone monooxygenase activity Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+. EC:1.14.13.84|KEGG_REACTION:R06892|MetaCyc:1.14.13.84-RXN|RHEA:22916|UM-BBD_reactionID:r0756 go.json (4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity|HAPMO http://purl.obolibrary.org/obo/GO_0033767 GO:0033766 biolink:MolecularActivity 2-hydroxyquinoline 8-monooxygenase activity Catalysis of the reaction: H+ + NADH + O2 + quinolin-2-ol = H2O + NAD+ + quinoline-2,8-diol. EC:1.14.13.61|KEGG_REACTION:R05158|MetaCyc:1.14.13.61-RXN|RHEA:22080 go.json 2-oxo-1,2-dihydroquinoline 8-monooxygenase activity|quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity http://purl.obolibrary.org/obo/GO_0033766 GO:0018128 biolink:MolecularActivity obsolete peptidyl-serine cyclase activity OBSOLETE. (Was not defined before being made obsolete). EC:4.2.1.- go.json peptidyl-serine cyclase activity True http://purl.obolibrary.org/obo/GO_0018128 GO:0018127 biolink:MolecularActivity NAD(P)-serine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine. go.json http://purl.obolibrary.org/obo/GO_0018127 GO:0018129 biolink:MolecularActivity peptidyl-oxazoline dehydrogenase activity Catalysis of the reduction of a peptide-linked oxazoline to oxazole. go.json http://purl.obolibrary.org/obo/GO_0018129 GO:0018124 biolink:BiologicalProcess peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue. RESID:AA0233 go.json http://purl.obolibrary.org/obo/GO_0018124 gocheck_do_not_annotate GO:0033765 biolink:MolecularActivity steroid dehydrogenase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative. go.json http://purl.obolibrary.org/obo/GO_0033765 GO:0033764 biolink:MolecularActivity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. Reactome:R-HSA-9758682 go.json http://purl.obolibrary.org/obo/GO_0033764 GO:0018123 biolink:BiologicalProcess obsolete peptidyl-cysteine ADP-ribosylation OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine. RESID:AA0169 go.json True http://purl.obolibrary.org/obo/GO_0018123 GO:0033763 biolink:MolecularActivity proline 3-hydroxylase activity Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2. EC:1.14.11.28|MetaCyc:1.14.11.28-RXN|RHEA:20265 go.json L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|P-3-H http://purl.obolibrary.org/obo/GO_0033763 GO:0018126 biolink:BiologicalProcess protein hydroxylation The addition of a hydroxy group to a protein amino acid. go.json protein amino acid hydroxylation http://purl.obolibrary.org/obo/GO_0018126 gocheck_do_not_annotate GO:0018125 biolink:BiologicalProcess peptidyl-cysteine methylation The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine. RESID:AA0234 go.json http://purl.obolibrary.org/obo/GO_0018125 gocheck_do_not_annotate GO:0033762 biolink:BiologicalProcess response to glucagon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. go.json response to glucagon stimulus http://purl.obolibrary.org/obo/GO_0033762 GO:0033761 biolink:MolecularActivity mugineic-acid 3-dioxygenase activity Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2. EC:1.14.11.25|KEGG_REACTION:R07186|MetaCyc:RXN-7982|RHEA:14509 go.json IDS2|mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0033761 GO:0018120 biolink:BiologicalProcess obsolete peptidyl-arginine ADP-ribosylation OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine. RESID:AA0168 go.json True http://purl.obolibrary.org/obo/GO_0018120 GO:0033760 biolink:MolecularActivity 2'-deoxymugineic-acid 2'-dioxygenase activity Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate. EC:1.14.11.24|KEGG_REACTION:R07185|MetaCyc:1.14.11.24-RXN|RHEA:12200 go.json 2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity|IDS3 http://purl.obolibrary.org/obo/GO_0033760 GO:0018122 biolink:BiologicalProcess obsolete peptidyl-asparagine ADP-ribosylation OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine. RESID:AA0231 go.json True http://purl.obolibrary.org/obo/GO_0018122 GO:0018121 biolink:MolecularActivity NAD(P)-asparagine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine. go.json http://purl.obolibrary.org/obo/GO_0018121 GO:0018140 biolink:BiologicalProcess peptide cross-linking via L-cysteine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0244 go.json http://purl.obolibrary.org/obo/GO_0018140 gocheck_do_not_annotate GO:0033759 biolink:MolecularActivity flavone synthase activity Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O. EC:1.14.20.5|MetaCyc:RXN-8000|RHEA:10448 go.json FNS I|flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity|flavone synthase I activity http://purl.obolibrary.org/obo/GO_0033759 GO:0033758 biolink:MolecularActivity clavaminate synthase activity Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O. EC:1.14.11.21|MetaCyc:1.14.11.21-RXN|RHEA:20021 go.json clavaminate synthase 2 activity|clavaminic acid synthase activity|deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0033758 GO:0033757 biolink:MolecularActivity glucoside 3-dehydrogenase activity Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor. EC:1.1.99.13|MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN|RHEA:16589|Wikipedia:Glucoside_3-dehydrogenase go.json D-aldohexopyranoside dehydrogenase|D-aldohexoside:(acceptor) 3-oxidoreductase|D-aldohexoside:acceptor 3-oxidoreductase|D-aldohexoside:cytochrome c oxidoreductase|hexopyranoside-cytochrome c oxidoreductase http://purl.obolibrary.org/obo/GO_0033757 GO:0033756 biolink:MolecularActivity Oplophorus-luciferin 2-monooxygenase activity Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu. EC:1.13.12.13|MetaCyc:RXN-3361|RHEA:20417 go.json Oplophorus luciferase activity|Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity http://purl.obolibrary.org/obo/GO_0033756 GO:0033755 biolink:MolecularActivity sulfur oxygenase/reductase activity Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+. EC:1.13.11.55|MetaCyc:1.13.11.55-RXN|RHEA:13957 go.json SOR|sulfur oxygenase activity|sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity|sulphur oxygenase/reductase activity http://purl.obolibrary.org/obo/GO_0033755 GO:0043102 biolink:BiologicalProcess amino acid salvage Any process which produces an amino acid from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0043102 GO:0043101 biolink:BiologicalProcess purine-containing compound salvage Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. go.json purine salvage http://purl.obolibrary.org/obo/GO_0043101 goslim_pir GO:0043104 biolink:BiologicalProcess positive regulation of GTP cyclohydrolase I activity Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I. go.json activation of GTP cyclohydrolase I activity|stimulation of GTP cyclohydrolase I activity|up regulation of GTP cyclohydrolase I activity|up-regulation of GTP cyclohydrolase I activity|upregulation of GTP cyclohydrolase I activity http://purl.obolibrary.org/obo/GO_0043104 gocheck_do_not_annotate GO:0043103 biolink:BiologicalProcess hypoxanthine salvage Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis. go.json adenine, hypoxanthine and their nucleoside salvage|guanine, xanthine and their nucleoside salvage http://purl.obolibrary.org/obo/GO_0043103 GO:0043100 biolink:BiologicalProcess pyrimidine nucleobase salvage Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis. go.json pyrimidine base salvage http://purl.obolibrary.org/obo/GO_0043100 GO:0043109 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043109 GO:0043106 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043106 GO:0018139 biolink:BiologicalProcess peptide cross-linking via L-phenylalanine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0243 go.json http://purl.obolibrary.org/obo/GO_0018139 gocheck_do_not_annotate GO:0043105 biolink:BiologicalProcess negative regulation of GTP cyclohydrolase I activity Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I. go.json down regulation of GTP cyclohydrolase I activity|down-regulation of GTP cyclohydrolase I activity|downregulation of GTP cyclohydrolase I activity|inhibition of GTP cyclohydrolase I activity http://purl.obolibrary.org/obo/GO_0043105 gocheck_do_not_annotate GO:0018138 biolink:BiologicalProcess peptide cross-linking via L-serine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0242 go.json http://purl.obolibrary.org/obo/GO_0018138 gocheck_do_not_annotate GO:0043108 biolink:BiologicalProcess pilus retraction The process of withdrawing a pilus back into a cell. go.json http://purl.obolibrary.org/obo/GO_0043108 GO:0043107 biolink:BiologicalProcess type IV pilus-dependent motility Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility. go.json TFP-dependent motility|TFP-dependent movement|social gliding motility|twitching motility|type 4 pilus-dependent motility|type four pilus-dependent motility http://purl.obolibrary.org/obo/GO_0043107 GO:0033754 biolink:MolecularActivity indoleamine 2,3-dioxygenase activity Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. EC:1.13.11.52|MetaCyc:RXN-8664|MetaCyc:RXN-8665|RHEA:14189 go.json D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity|IDO|tryptophan pyrrolase activity http://purl.obolibrary.org/obo/GO_0033754 GO:0018135 biolink:MolecularActivity obsolete peptidyl-cysteine cyclase activity OBSOLETE. (Was not defined before being made obsolete). EC:4.2.1.- go.json peptidyl-cysteine cyclase activity True http://purl.obolibrary.org/obo/GO_0018135 GO:0033753 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033753 GO:0018134 biolink:BiologicalProcess peptide cross-linking via glycine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0240 go.json http://purl.obolibrary.org/obo/GO_0018134 gocheck_do_not_annotate GO:0033752 biolink:MolecularActivity acetylacetone-cleaving enzyme activity Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal. EC:1.13.11.50|RHEA:12877 go.json Dke1|acetylacetone dioxygenase activity|acetylacetone-cleaving enzyme|acetylacetone:oxygen oxidoreductase activity|diketone cleaving dioxygenase activity|diketone cleaving enzyme http://purl.obolibrary.org/obo/GO_0033752 GO:0018137 biolink:BiologicalProcess peptide cross-linking via glycine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0241 go.json http://purl.obolibrary.org/obo/GO_0018137 gocheck_do_not_annotate GO:0033751 biolink:MolecularActivity obsolete linoleate 8R-lipoxygenase OBSOLETE. Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate. go.json 5,8-linoleate diol synthase (bifunctional enzyme)|7,8-linoleate diol synthase (bifunctional enzyme)|linoleate diol synthase activity True http://purl.obolibrary.org/obo/GO_0033751 GO:0018136 biolink:MolecularActivity peptidyl-thiazoline dehydrogenase activity Catalysis of the reduction of a peptide-linked thiazoline to thiazole. go.json http://purl.obolibrary.org/obo/GO_0018136 GO:0018131 biolink:BiologicalProcess oxazole or thiazole biosynthetic process The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. go.json oxazole or thiazole anabolism|oxazole or thiazole biosynthesis|oxazole or thiazole formation|oxazole or thiazole synthesis http://purl.obolibrary.org/obo/GO_0018131 GO:0033750 biolink:BiologicalProcess ribosome localization A process in which a ribosome is transported to, and/or maintained in, a specific location. go.json establishment of ribosome localisation|establishment of ribosome localization|ribosome localisation http://purl.obolibrary.org/obo/GO_0033750 GO:0018130 biolink:BiologicalProcess heterocycle biosynthetic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). go.json heterocycle anabolism|heterocycle biosynthesis|heterocycle formation|heterocycle synthesis http://purl.obolibrary.org/obo/GO_0018130 GO:0018133 biolink:BiologicalProcess peptide cross-linking via L-cysteine oxazolinecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue. RESID:AA0239 go.json http://purl.obolibrary.org/obo/GO_0018133 gocheck_do_not_annotate GO:0018132 biolink:BiologicalProcess peptide cross-linking via L-cysteine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0238 go.json http://purl.obolibrary.org/obo/GO_0018132 gocheck_do_not_annotate GO:0033749 biolink:MolecularActivity histone H4R3 demethylase activity Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. go.json histone H4-methyl-arginine-3 demethylase activity|histone H4R3me demethylase activity|histone demethylase activity (H4-R3 specific) http://purl.obolibrary.org/obo/GO_0033749 GO:0033748 biolink:MolecularActivity hydrogenase (acceptor) activity Catalysis of the reaction: H2 + A = AH2. EC:1.12.99.6|MetaCyc:RXN0-4141|MetaCyc:RXN0-5256|RHEA:12116 go.json H2 producing hydrogenase activity|hydrogen-lyase activity|hydrogen:(acceptor) oxidoreductase activity|hydrogen:acceptor oxidoreductase activity|hydrogenlyase activity|uptake hydrogenase activity http://purl.obolibrary.org/obo/GO_0033748 GO:0033747 biolink:MolecularActivity obsolete versatile peroxidase activity OBSOLETE. Catalysis of the reactions: Reactive Black 5 + hydrogen peroxide = oxidized Reactive Black 5 + 2 H2O, and donor + hydrogen peroxide = oxidized donor + 2 H2O. go.json VP|hybrid peroxidase activity|polyvalent peroxidase activity|reactive-black-5:hydrogen-peroxide oxidoreductase activity|versatile peroxidase activity True http://purl.obolibrary.org/obo/GO_0033747 GO:0033746 biolink:MolecularActivity histone H3R2 demethylase activity Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. go.json histone H3-R2 demethylase activity|histone H3-methyl-arginine-2 demethylase activity|histone H3R2me demethylase activity|histone demethylase activity (H3-R2 specific) http://purl.obolibrary.org/obo/GO_0033746 GO:0033745 biolink:MolecularActivity L-methionine-(R)-S-oxide reductase activity Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin. EC:1.8.4.14|MetaCyc:1.8.4.14-RXN|RHEA:21260 go.json FRMsr|L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity|free met-R-(o) reductase activity|free-methionine (R)-S-oxide reductase activity|methionine-R-sulfoxide reductase activity http://purl.obolibrary.org/obo/GO_0033745 GO:0008789 biolink:MolecularActivity altronate dehydratase activity Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O. EC:4.2.1.7|KEGG_REACTION:R01540|MetaCyc:ALTRODEHYDRAT-RXN|RHEA:15957 go.json D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)|D-altronate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0008789 GO:0008788 biolink:MolecularActivity alpha,alpha-phosphotrehalase activity Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate. EC:3.2.1.93|MetaCyc:TRE6PHYDRO-RXN|RHEA:23008 go.json alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity|phosphotrehalase activity|trehalose-6-phosphate hydrolase activity http://purl.obolibrary.org/obo/GO_0008788 GO:0033744 biolink:MolecularActivity L-methionine:thioredoxin-disulfide S-oxidoreductase activity Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. EC:1.8.4.13|KEGG_REACTION:R07606|MetaCyc:1.8.4.13-RXN|RHEA:19993 go.json L-methionine-(S)-S-oxide reductase activity|L-methionine:oxidized-thioredoxin S-oxidoreductase activity|acetylmethionine sulfoxide reductase activity|fSMsr|free-methionine (S)-S-oxide reductase activity|methionine sulfoxide reductase activity|methionine-S-oxide reductase activity|methyl sulfoxide reductase I and II activity http://purl.obolibrary.org/obo/GO_0033744 GO:0008787 biolink:MolecularActivity allose kinase activity Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate. EC:2.7.1.55|MetaCyc:ALLOSE-KINASE-RXN|RHEA:14805 go.json ATP:D-allose 6-phosphotransferase activity|D-allokinase activity|D-allose-6-kinase activity|allokinase (phosphorylating)|allokinase activity http://purl.obolibrary.org/obo/GO_0008787 GO:0043113 biolink:BiologicalProcess receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. go.json http://purl.obolibrary.org/obo/GO_0043113 GO:0043112 biolink:BiologicalProcess receptor metabolic process The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json receptor metabolism http://purl.obolibrary.org/obo/GO_0043112 GO:0008786 biolink:MolecularActivity allose 6-phosphate isomerase activity Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate. MetaCyc:RXN0-303|RHEA:28430 go.json http://purl.obolibrary.org/obo/GO_0008786 GO:0043115 biolink:MolecularActivity precorrin-2 dehydrogenase activity Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin. EC:1.3.1.76|KEGG_REACTION:R03947|MetaCyc:DIMETHUROPORDEHYDROG-RXN|RHEA:15613 go.json 1,3-dimethyluroporphyrinogen III dehydrogenase activity|CysG|Met8p|SirC|dihydrosirohydrochlorin dehydrogenase activity|precorrin-2 oxidase activity|precorrin-2:NAD+ oxidoreductase activity|siroheme synthase activity http://purl.obolibrary.org/obo/GO_0043115 GO:0008785 biolink:MolecularActivity alkyl hydroperoxide reductase activity Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. Reactome:R-HSA-1222526|UM-BBD_reactionID:r0684 go.json http://purl.obolibrary.org/obo/GO_0008785 GO:0008784 biolink:MolecularActivity alanine racemase activity Catalysis of the reaction: L-alanine = D-alanine. EC:5.1.1.1|KEGG_REACTION:R00401|MetaCyc:ALARACECAT-RXN|RHEA:20249 go.json L-alanine racemase activity http://purl.obolibrary.org/obo/GO_0008784 GO:0043114 biolink:BiologicalProcess regulation of vascular permeability Any process that modulates the extent to which blood vessels can be pervaded by fluid. go.json http://purl.obolibrary.org/obo/GO_0043114 GO:0008783 biolink:MolecularActivity agmatinase activity Catalysis of the reaction: agmatine + H2O = putrescine + urea. EC:3.5.3.11|KEGG_REACTION:R01157|MetaCyc:AGMATIN-RXN|RHEA:13929|Reactome:R-HSA-350604 go.json SpeB|agmatine amidinohydrolase|agmatine ureohydrolase activity http://purl.obolibrary.org/obo/GO_0008783 GO:0008782 biolink:MolecularActivity adenosylhomocysteine nucleosidase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine. EC:3.2.2.9|MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN|RHEA:17805 go.json 5'-methyladenosine nucleosidase activity|AdoHcy/MTA nucleosidase activity|S-adenosyl-L-homocysteine homocysteinylribohydrolase activity|S-adenosylhomocysteine hydrolase activity|S-adenosylhomocysteine nucleosidase activity|S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity http://purl.obolibrary.org/obo/GO_0008782 GO:0008781 biolink:MolecularActivity N-acylneuraminate cytidylyltransferase activity Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. EC:2.7.7.43|MetaCyc:RXN-9990|RHEA:11344|Reactome:R-HSA-4084982 go.json CMP-N-acetylneuraminate synthase activity|CMP-N-acetylneuraminate synthetase activity|CMP-N-acetylneuraminic acid synthase activity|CMP-N-acetylneuraminic acid synthetase activity|CMP-NANA synthetase activity|CMP-Neu5Ac synthetase activity|CMP-NeuAc synthetase activity|CMP-NeuNAc synthetase activity|CMP-sialate diphosphorylase activity|CMP-sialate pyrophosphorylase activity|CMP-sialate synthase activity|CMP-sialate synthetase activity|CMP-sialic acid synthetase activity|CMP-sialic synthetase activity|CTP:N-acylneuraminate cytidylyltransferase activity|acetylneuraminate cytidylyltransferase activity|acylneuraminate cytidyltransferase activity|cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity|cytidine 5'-monophosphosialic acid synthetase activity|cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity|cytidine monophosphoacetylneuraminic synthetase activity|cytidine monophosphosialate pyrophosphorylase activity|cytidine monophosphosialate synthetase activity|cytidine monophosphosialic acid synthetase activity http://purl.obolibrary.org/obo/GO_0008781 GO:0043111 biolink:BiologicalProcess replication fork arrest Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. go.json negative regulation of DNA replication at replication fork barrier|replication fork blocking|replication fork stalling http://purl.obolibrary.org/obo/GO_0043111 GO:0008780 biolink:MolecularActivity acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. EC:2.3.1.129|MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN|RHEA:13925 go.json (R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity|UDP-N-acetylglucosamine acyltransferase activity|acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity|acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity|acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase|uridine diphosphoacetylglucosamine acyltransferase activity http://purl.obolibrary.org/obo/GO_0008780 GO:0043110 biolink:MolecularActivity rDNA spacer replication fork barrier binding Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription. go.json RFB binding http://purl.obolibrary.org/obo/GO_0043110 GO:0008790 biolink:MolecularActivity arabinose isomerase activity Catalysis of the reaction: D-arabinose = D-ribulose. EC:5.3.1.3|MetaCyc:DARABISOM-RXN|RHEA:13849 go.json D-arabinose aldose-ketose-isomerase activity|D-arabinose isomerase activity|D-arabinose ketol-isomerase activity|D-arabinose(L-fucose) isomerase activity http://purl.obolibrary.org/obo/GO_0008790 GO:0018109 biolink:BiologicalProcess peptidyl-arginine phosphorylation The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine. RESID:AA0222 go.json http://purl.obolibrary.org/obo/GO_0018109 gocheck_do_not_annotate GO:0018106 biolink:BiologicalProcess peptidyl-histidine phosphorylation The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). RESID:AA0035|RESID:AA0036 go.json http://purl.obolibrary.org/obo/GO_0018106 gocheck_do_not_annotate GO:0043117 biolink:BiologicalProcess positive regulation of vascular permeability Any process that increases the extent to which blood vessels can be pervaded by fluid. go.json activation of vascular permeability|stimulation of vascular permeability|up regulation of vascular permeability|up-regulation of vascular permeability|upregulation of vascular permeability http://purl.obolibrary.org/obo/GO_0043117 GO:0018105 biolink:BiologicalProcess peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. RESID:AA0037 go.json http://purl.obolibrary.org/obo/GO_0018105 gocheck_do_not_annotate GO:0043116 biolink:BiologicalProcess negative regulation of vascular permeability Any process that reduces the extent to which blood vessels can be pervaded by fluid. go.json down regulation of vascular permeability|down-regulation of vascular permeability|downregulation of vascular permeability|inhibition of vascular permeability http://purl.obolibrary.org/obo/GO_0043116 GO:0018108 biolink:BiologicalProcess peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. RESID:AA0039 go.json http://purl.obolibrary.org/obo/GO_0018108 gocheck_do_not_annotate GO:0043119 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043119 GO:0018107 biolink:BiologicalProcess peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. RESID:AA0038 go.json http://purl.obolibrary.org/obo/GO_0018107 gocheck_do_not_annotate GO:0043118 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043118 GO:0033743 biolink:MolecularActivity peptide-methionine (R)-S-oxide reductase activity Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. EC:1.8.4.12|KEGG_REACTION:R07607|MetaCyc:1.8.4.12-RXN|RHEA:24164|Reactome:R-HSA-5676917 go.json MsrB|PilB|SelR|SelX|methionine S-oxide reductase (R-form oxidizing) activity|methionine S-oxide reductase activity|methionine sulfoxide reductase B activity|methionine sulfoxide reductase activity|pMRsr|pMSR|peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity|protein-methionine-R-oxide reductase activity|selenoprotein R http://purl.obolibrary.org/obo/GO_0033743 GO:0018102 biolink:BiologicalProcess peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine. RESID:AA0215 go.json http://purl.obolibrary.org/obo/GO_0018102 gocheck_do_not_annotate GO:0018101 biolink:BiologicalProcess obsolete protein citrullination OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline. RESID:AA0214 go.json deimination|peptidyl-citrulline anabolism from peptidyl-arginine|peptidyl-citrulline biosynthetic process from peptidyl-arginine|peptidyl-citrulline formation from peptidyl-arginine|peptidyl-citrulline synthesis from peptidyl-arginine True http://purl.obolibrary.org/obo/GO_0018101 GO:0033742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033742 GO:0033741 biolink:MolecularActivity adenylyl-sulfate reductase (glutathione) activity Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione. EC:1.8.4.9|KEGG_REACTION:R05717|MetaCyc:1.8.4.9-RXN|RHEA:14141 go.json 5'-adenylylsulfate reductase activity|AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity|AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity|plant-type 5'-adenylylsulfate reductase activity http://purl.obolibrary.org/obo/GO_0033741 GO:0018104 biolink:BiologicalProcess peptidoglycan-protein cross-linking The process of covalently linking peptidoglycan (murein) to proteins. go.json http://purl.obolibrary.org/obo/GO_0018104 GO:0033740 biolink:MolecularActivity hydroxylamine oxidoreductase activity Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor. EC:1.7.2.8|MetaCyc:1.7.99.8-RXN|RHEA:23232 go.json hydroxylamine:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033740 GO:0018103 biolink:BiologicalProcess protein C-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom. RESID:AA0217 go.json protein amino acid C-linked glycosylation http://purl.obolibrary.org/obo/GO_0018103 GO:0033739 biolink:MolecularActivity preQ1 synthase activity Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH. EC:1.7.1.13|KEGG_REACTION:R07605|MetaCyc:RXN0-4022|RHEA:13409 go.json 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity|7-cyano-7-deazaguanine reductase activity|QueF|YkvM|preQ0 oxidoreductase activity|preQ0 reductase activity|queuine synthase activity|queuine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033739 GO:0033738 biolink:MolecularActivity methylenetetrahydrofolate reductase (ferredoxin) activity Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin. EC:1.5.7.1|MetaCyc:RXN-5061|RHEA:14229 go.json 5,10-methylenetetrahydrofolate reductase activity|5-methyltetrahydrofolate:ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033738 GO:0033737 biolink:MolecularActivity 1-pyrroline dehydrogenase activity Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+. EC:1.2.1.19|MetaCyc:1.5.1.35-RXN go.json 1-pyrroline:NAD+ oxidoreductase activity|ABALDH|YdcW|gamma-aminobutyraldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033737 GO:0033736 biolink:MolecularActivity L-lysine 6-oxidase activity Catalysis of the reaction: L-lysine + H2O + O2 = allysine + H2O2 + NH4. EC:1.4.3.20|KEGG_REACTION:R07598|MetaCyc:1.4.3.20-RXN|RHEA:22548 go.json L-lysine-epsilon-oxidase activity|L-lysine:oxygen 6-oxidoreductase (deaminating) activity|Lod|LodA|marinocine http://purl.obolibrary.org/obo/GO_0033736 GO:0033735 biolink:MolecularActivity aspartate dehydrogenase activity Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+. EC:1.4.1.21|KEGG_REACTION:R07164|KEGG_REACTION:R07165|MetaCyc:1.4.1.21-RXN go.json L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity|NAD-dependent aspartate dehydrogenase activity|NADH2-dependent aspartate dehydrogenase activity|NADP+-dependent aspartate dehydrogenase activity|aspartate dehydrogenase NAD activity|aspartate dehydrogenase NADP activity http://purl.obolibrary.org/obo/GO_0033735 GO:0033734 biolink:MolecularActivity (R)-benzylsuccinyl-CoA dehydrogenase activity Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein. EC:1.3.8.3|RHEA:20876|UM-BBD_reactionID:r0330 go.json (R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity|(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity|BbsG http://purl.obolibrary.org/obo/GO_0033734 GO:0033733 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033733 GO:0008799 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008799 GO:0043124 biolink:BiologicalProcess negative regulation of canonical NF-kappaB signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. go.json down regulation of I-kappaB kinase/NF-kappaB cascade|down-regulation of I-kappaB kinase/NF-kappaB cascade|downregulation of I-kappaB kinase/NF-kappaB cascade|inhibition of I-kappaB kinase/NF-kappaB cascade|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of I-kappaB kinase/NF-kappaB signaling http://purl.obolibrary.org/obo/GO_0043124 GO:0008798 biolink:MolecularActivity beta-aspartyl-peptidase activity Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. EC:3.4.19.5|MetaCyc:3.4.19.5-RXN|Reactome:R-HSA-5692495|Reactome:R-HSA-5696365 go.json beta-aspartyl dipeptidase activity|beta-aspartyl peptidase activity http://purl.obolibrary.org/obo/GO_0008798 GO:0043123 biolink:BiologicalProcess positive regulation of canonical NF-kappaB signal transduction Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. go.json activation of I-kappaB kinase/NF-kappaB cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of I-kappaB kinase/NF-kappaB signaling|stimulation of I-kappaB kinase/NF-kappaB cascade|up regulation of I-kappaB kinase/NF-kappaB cascade|up-regulation of I-kappaB kinase/NF-kappaB cascade|upregulation of I-kappaB kinase/NF-kappaB cascade http://purl.obolibrary.org/obo/GO_0043123 GO:0008797 biolink:MolecularActivity aspartate ammonia-lyase activity Catalysis of the reaction: L-aspartate = fumarate + NH3. EC:4.3.1.1|MetaCyc:ASPARTASE-RXN|RHEA:16601 go.json L-aspartase activity|L-aspartate ammonia-lyase (fumarate-forming)|L-aspartate ammonia-lyase activity|aspartase activity|fumaric aminase activity http://purl.obolibrary.org/obo/GO_0008797 GO:0043126 biolink:BiologicalProcess obsolete regulation of 1-phosphatidylinositol 4-kinase activity OBSOLETE. Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase. go.json regulation of PI4K activity True http://purl.obolibrary.org/obo/GO_0043126 GO:0008796 biolink:MolecularActivity bis(5'-nucleosyl)-tetraphosphatase activity Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. go.json http://purl.obolibrary.org/obo/GO_0008796 GO:0008795 biolink:MolecularActivity NAD+ synthase activity Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. EC:6.3.1.5|MetaCyc:NAD-SYNTH-NH3-RXN|RHEA:21188 go.json NAD synthase (AMP-forming)|NAD synthase activity|NAD synthetase activity|NAD(+) synthetase activity|NAD+ synthetase activity|deamido-NAD+:ammonia ligase (AMP-forming)|diphosphopyridine nucleotide synthetase activity|nicotinamide adenine dinucleotide synthetase activity http://purl.obolibrary.org/obo/GO_0008795 GO:0043125 biolink:MolecularActivity ErbB-3 class receptor binding Binding to the protein-tyrosine kinase receptor ErbB-3/HER3. go.json HER3 receptor binding|Neu/ErbB-2 receptor activity http://purl.obolibrary.org/obo/GO_0043125 GO:0008794 biolink:MolecularActivity arsenate reductase (glutaredoxin) activity Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. EC:1.20.4.1|MetaCyc:RXN-982|RHEA:22016|UM-BBD_reactionID:r0635 go.json glutharedoxin:arsenate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008794 GO:0043120 biolink:MolecularActivity tumor necrosis factor binding Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. go.json http://purl.obolibrary.org/obo/GO_0043120 GO:0008793 biolink:MolecularActivity aromatic-amino-acid:2-oxoglutarate aminotransferase activity Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. EC:2.6.1.57|MetaCyc:2.6.1.57-RXN|RHEA:17533|UM-BBD_reactionID:r0297 go.json ArAT|aromatic amino acid aminotransferase activity|aromatic amino acid transferase activity|aromatic aminotransferase activity|aromatic-amino-acid transaminase activity http://purl.obolibrary.org/obo/GO_0008793 GO:0043122 biolink:BiologicalProcess regulation of canonical NF-kappaB signal transduction Any process that modulates the canonical NF-kappaB signaling cascade. go.json regulation of I-kappaB kinase/NF-kappaB cascade|regulation of I-kappaB kinase/NF-kappaB signaling http://purl.obolibrary.org/obo/GO_0043122 GO:0008792 biolink:MolecularActivity arginine decarboxylase activity Catalysis of the reaction: L-arginine + H+ = agmatine + CO2. EC:4.1.1.19|KEGG_REACTION:R00566|MetaCyc:ARGDECARBOX-RXN|RHEA:17641|Reactome:R-HSA-350598 go.json L-arginine carboxy-lyase (agmatine-forming)|L-arginine carboxy-lyase activity|SpeA http://purl.obolibrary.org/obo/GO_0008792 GO:0043121 biolink:MolecularActivity neurotrophin binding Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. go.json NT 4/5 binding|NT-3 binding|NT-4 binding|NT-4/5 binding|NT-5 binding|NT3 binding|NT4 binding|NT5 binding|neurotrophic factor binding|neurotrophin 3 binding|neurotrophin 4/5 binding|neurotrophin TRK receptor activity|neurotrophin TRKA receptor activity|neurotrophin TRKB receptor activity|neurotrophin TRKC receptor activity|neurotrophin-3 binding|neurotrophin-4/5 binding http://purl.obolibrary.org/obo/GO_0043121 GO:0008791 biolink:MolecularActivity arginine N-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine. EC:2.3.1.109|MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN|RHEA:15185 go.json AOST activity|AST activity|AstA|arginine and ornithine N(2)-succinyltransferase activity|arginine and ornithine N2-succinyltransferase activity|arginine succinyltransferase activity|succinyl-CoA:L-arginine 2-N-succinyltransferase activity|succinyl-CoA:L-arginine N2-succinyltransferase activity http://purl.obolibrary.org/obo/GO_0008791 GO:0018117 biolink:BiologicalProcess protein adenylylation The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid. go.json protein AMPylation|protein adenylation|protein amino acid adenylylation http://purl.obolibrary.org/obo/GO_0018117 gocheck_do_not_annotate GO:0043128 biolink:BiologicalProcess obsolete positive regulation of 1-phosphatidylinositol 4-kinase activity OBSOLETE. Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase. go.json activation of 1-phosphatidylinositol 4-kinase activity|positive regulation of PI4K activity|stimulation of 1-phosphatidylinositol 4-kinase activity|up regulation of 1-phosphatidylinositol 4-kinase activity|up-regulation of 1-phosphatidylinositol 4-kinase activity|upregulation of 1-phosphatidylinositol 4-kinase activity True http://purl.obolibrary.org/obo/GO_0043128 GO:0043127 biolink:BiologicalProcess obsolete negative regulation of 1-phosphatidylinositol 4-kinase activity OBSOLETE. Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase. go.json down regulation of 1-phosphatidylinositol 4-kinase activity|down-regulation of 1-phosphatidylinositol 4-kinase activity|downregulation of 1-phosphatidylinositol 4-kinase activity|inhibition of 1-phosphatidylinositol 4-kinase activity|negative regulation of PI4K activity True http://purl.obolibrary.org/obo/GO_0043127 GO:0018116 biolink:BiologicalProcess peptidyl-lysine adenylylation The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine. RESID:AA0227 go.json peptidyl-lysine adenylation http://purl.obolibrary.org/obo/GO_0018116 gocheck_do_not_annotate GO:0018119 biolink:BiologicalProcess peptidyl-cysteine S-nitrosylation The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine. RESID:AA0230 go.json S-nitrosylation|protein S-nitrosylation http://purl.obolibrary.org/obo/GO_0018119 gocheck_do_not_annotate GO:0018118 biolink:BiologicalProcess obsolete peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine OBSOLETE. The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide. go.json peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine True http://purl.obolibrary.org/obo/GO_0018118 GO:0043129 biolink:BiologicalProcess surfactant homeostasis Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. go.json regulation of liquid surface tension|regulation of surface tension of a liquid|surfactant activity http://purl.obolibrary.org/obo/GO_0043129 GO:0033732 biolink:MolecularActivity pyrroloquinoline-quinone synthase activity Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone. EC:1.3.3.11|KEGG_REACTION:R07353|MetaCyc:RXN-11181|RHEA:10692 go.json 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity|PqqC http://purl.obolibrary.org/obo/GO_0033732 GO:0018113 biolink:MolecularActivity lysine racemase activity Catalysis of the reaction: L-lysine = D-lysine. EC:5.1.1.5|MetaCyc:LYSINE-RACEMASE-RXN|RHEA:22864 go.json http://purl.obolibrary.org/obo/GO_0018113 GO:0033731 biolink:MolecularActivity arogenate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2. EC:1.3.1.79|MetaCyc:RXN-14476 go.json L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity|arogenic dehydrogenase activity|pretyrosine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033731 GO:0018112 biolink:MolecularActivity proline racemase activity Catalysis of the reaction: L-proline = D-proline. EC:5.1.1.4|KEGG_REACTION:R01255|MetaCyc:PROLINE-RACEMASE-RXN|RHEA:10680 go.json http://purl.obolibrary.org/obo/GO_0018112 GO:0033730 biolink:MolecularActivity arogenate dehydrogenase (NADP+) activity Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2. EC:1.3.1.78|MetaCyc:RXN-5682|RHEA:15417 go.json L-arogenate:NADP+ oxidoreductase (decarboxylating) activity|TyrAAT1|TyrAAT2|TyrAa|arogenic dehydrogenase activity|pretyrosine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033730 GO:0018115 biolink:BiologicalProcess peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine. RESID:AA0223 go.json peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine|peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0018115 gocheck_do_not_annotate GO:0018114 biolink:MolecularActivity threonine racemase activity Catalysis of the reaction: L-threonine = D-threonine. EC:5.1.1.6|KEGG_REACTION:R01467|MetaCyc:THREONINE-RACEMASE-RXN|RHEA:13913 go.json http://purl.obolibrary.org/obo/GO_0018114 GO:0018111 biolink:MolecularActivity methionine racemase activity Catalysis of the reaction: L-methionine = D-methionine. EC:5.1.1.2|KEGG_REACTION:R00655|MetaCyc:METHIONINE-RACEMASE-RXN|RHEA:12492 go.json http://purl.obolibrary.org/obo/GO_0018111 GO:0018110 biolink:MolecularActivity obsolete histone arginine kinase activity OBSOLETE. Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H+. go.json histone-arginine kinase activity True http://purl.obolibrary.org/obo/GO_0018110 GO:0033729 biolink:MolecularActivity anthocyanidin reductase activity Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+. EC:1.3.1.77|MetaCyc:RXN-10693 go.json ANR|AtANR|MtANR|flavan-3-ol:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033729 GO:0033728 biolink:MolecularActivity divinyl chlorophyllide a 8-vinyl-reductase activity Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+. EC:1.3.1.75|MetaCyc:RXN-5286|RHEA:14449 go.json 4VCR|[4-vinyl]chlorophyllide a reductase activity|chlorophyllide-a:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033728 GO:0033727 biolink:MolecularActivity aldehyde dehydrogenase (FAD-independent) activity Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor. EC:1.2.99.7|MetaCyc:1.2.99.3-RXN|MetaCyc:1.2.99.7-RXN|MetaCyc:CARBOXYLATE-REDUCTASE-RXN go.json AORDd|Mop|aldehyde oxidoreductase activity|aldehyde:acceptor oxidoreductase (FAD-independent) activity http://purl.obolibrary.org/obo/GO_0033727 GO:0033726 biolink:MolecularActivity aldehyde ferredoxin oxidoreductase activity Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin. EC:1.2.7.5|MetaCyc:1.2.7.5-RXN|RHEA:16421 go.json AOR|aldehyde:ferredoxin oxidoreductase activity|tungsten-containing aldehyde ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033726 GO:0008769 biolink:MolecularActivity obsolete X-His dipeptidase activity OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides. EC:3.4.13.3|MetaCyc:3.4.13.3-RXN go.json X-His dipeptidase activity|Xaa-His dipeptidase activity|aminoacyl-histidine dipeptidase activity|aminoacylhistidine dipeptidase activity|carnosinase activity|dipeptidase M|homocarnosinase activity True http://purl.obolibrary.org/obo/GO_0008769 GO:0033725 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033725 GO:0008768 biolink:MolecularActivity UDP-sugar diphosphatase activity Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. EC:3.6.1.45|MetaCyc:UDPSUGARHYDRO-RXN|Reactome:R-HSA-6810464 go.json UDP-sugar hydrolase activity|UDP-sugar pyrophosphatase activity|UDP-sugar sugarphosphohydrolase activity|nucleosidediphosphate-sugar diphosphatase activity|nucleosidediphosphate-sugar pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0008768 GO:0033724 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033724 GO:0008767 biolink:MolecularActivity UDP-galactopyranose mutase activity Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. EC:5.4.99.9|MetaCyc:GALPMUT-RXN|RHEA:24132 go.json UDP-D-galactopyranose furanomutase activity|UDPgalactopyranose mutase activity http://purl.obolibrary.org/obo/GO_0008767 GO:0033723 biolink:MolecularActivity fluoroacetaldehyde dehydrogenase activity Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+. EC:1.2.1.69|RHEA:16677 go.json fluoroacetaldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033723 GO:0008766 biolink:MolecularActivity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. EC:6.3.2.10|MetaCyc:UDP-NACMURALGLDAPAALIG-RXN|RHEA:28374 go.json http://purl.obolibrary.org/obo/GO_0008766 GO:0033722 biolink:MolecularActivity malonate-semialdehyde dehydrogenase activity Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+. EC:1.2.1.15|MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN go.json 3-oxopropanoate:NAD(P)+ oxidoreductase activity|malonic semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033722 GO:0008765 biolink:MolecularActivity UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate. EC:6.3.2.13|KEGG_REACTION:R02788|MetaCyc:UDP-NACMURALGLDAPLIG-RXN|RHEA:23676 go.json MurE synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity|UDP-N-acetylmuramyl-tripeptide synthetase activity http://purl.obolibrary.org/obo/GO_0008765 GO:0043135 biolink:MolecularActivity 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+. MetaCyc:RXN-10969 go.json PRPP pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0043135 GO:0008764 biolink:MolecularActivity UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. EC:6.3.2.9|KEGG_REACTION:R02783|MetaCyc:UDP-NACMURALA-GLU-LIG-RXN|RHEA:16429 go.json D-glutamate ligase activity|D-glutamate-adding enzyme activity|MurD synthetase activity|UDP-Mur-NAC-L-Ala:D-Glu ligase activity|UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity|uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity http://purl.obolibrary.org/obo/GO_0008764 GO:0043134 biolink:BiologicalProcess regulation of hindgut contraction Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. go.json http://purl.obolibrary.org/obo/GO_0043134 GO:0043137 biolink:BiologicalProcess DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. go.json Okazaki initiator RNA removal http://purl.obolibrary.org/obo/GO_0043137 GO:0008763 biolink:MolecularActivity UDP-N-acetylmuramate-L-alanine ligase activity Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine. EC:6.3.2.8|KEGG_REACTION:R03193|MetaCyc:UDP-NACMUR-ALA-LIG-RXN|RHEA:23372 go.json L-Ala ligase activity|L-alanine-adding enzyme activity|MurC synthetase activity|UDP-MurNAc:L-alanine ligase activity|UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)|UDP-N-acetylmuramoyl-L-alanine synthetase activity|UDP-N-acetylmuramoylalanine synthetase activity|UDP-N-acetylmuramyl:L-alanine ligase activity|UDP-acetylmuramyl-L-alanine synthetase activity|UDPMurNAc-L-alanine synthetase activity|alanine-adding enzyme activity|uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity|uridine diphosphate N-acetylmuramate:L-alanine ligase activity|uridine diphospho-N-acetylmuramoylalanine synthetase activity|uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity http://purl.obolibrary.org/obo/GO_0008763 GO:0043136 biolink:MolecularActivity glycerol-3-phosphatase activity Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate. MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN|Reactome:R-HSA-8955794 go.json http://purl.obolibrary.org/obo/GO_0043136 GO:0008762 biolink:MolecularActivity UDP-N-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. EC:1.3.1.98|MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN|RHEA:12248 go.json MurB reductase|UDP-GlcNAc-enoylpyruvate reductase activity|UDP-N-acetylenolpyruvoylglucosamine reductase activity|UDP-N-acetylglucosamine-enoylpyruvate reductase activity|UDP-N-acetylmuramate:NADP+ oxidoreductase activity|uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity|uridine diphosphoacetylpyruvoylglucosamine reductase activity|uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008762 GO:0008761 biolink:MolecularActivity UDP-N-acetylglucosamine 2-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. EC:5.1.3.14|MetaCyc:UDPGLCNACEPIM-RXN|RHEA:17213|Reactome:R-HSA-4085021|Reactome:R-HSA-4088338 go.json UDP-GlcNAc-2-epimerase activity|UDP-N-acetyl-D-glucosamine 2-epimerase activity|UDP-N-acetylglucosamine 2'-epimerase activity|uridine diphosphate-N-acetylglucosamine-2'-epimerase activity|uridine diphospho-N-acetylglucosamine 2'-epimerase activity|uridine diphosphoacetylglucosamine 2'-epimerase activity http://purl.obolibrary.org/obo/GO_0008761 GO:0043131 biolink:BiologicalProcess erythrocyte enucleation The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation. go.json http://purl.obolibrary.org/obo/GO_0043131 GO:0043130 biolink:MolecularActivity ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. Reactome:R-HSA-1169404|Reactome:R-HSA-205008|Reactome:R-HSA-983152 go.json http://purl.obolibrary.org/obo/GO_0043130 GO:0008760 biolink:MolecularActivity UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. EC:2.5.1.7|KEGG_REACTION:R00660|MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN|RHEA:18681 go.json MurA transferase activity|UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity|UDP-N-acetylglucosamine enoylpyruvyltransferase activity|enoylpyruvate transferase activity|phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity|phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity|phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity|phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity|phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity|phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity|pyruvate-UDP-acetylglucosamine transferase activity|pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity|pyruvate-uridine diphospho-N-acetylglucosamine transferase activity|pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0008760 GO:0043133 biolink:BiologicalProcess hindgut contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. go.json http://purl.obolibrary.org/obo/GO_0043133 GO:0043132 biolink:BiologicalProcess NAD transport The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH. go.json NAD (oxidized) transport|NAD (reduced) transport|NADH transport|nicotinamide adenine dinucleotide transport|oxidized NAD transport|oxidized nicotinamide adenine dinucleotide transport|reduced NAD transport|reduced nicotinamide adenine dinucleotide transport http://purl.obolibrary.org/obo/GO_0043132 GO:0043139 biolink:MolecularActivity 5'-3' DNA helicase activity Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. EC:5.6.2.3|Reactome:R-HSA-6782131 go.json 5' to 3' DNA helicase activity|ATP-dependent 5' to 3' DNA helicase activity|ATP-dependent 5'-3' DNA helicase activity|DNA helicase IV activity http://purl.obolibrary.org/obo/GO_0043139 GO:0043138 biolink:MolecularActivity 3'-5' DNA helicase activity Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. EC:5.6.2.4|Reactome:R-HSA-167097|Reactome:R-HSA-174438|Reactome:R-HSA-75949|Reactome:R-HSA-9613490|Reactome:R-HSA-9613494|Reactome:R-HSA-9613497|Reactome:R-HSA-9613498|Reactome:R-HSA-9684118 go.json 3' to 5' DNA helicase activity|ATP-dependent 3' to 5' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity http://purl.obolibrary.org/obo/GO_0043138 GO:0033721 biolink:MolecularActivity aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+. EC:1.2.1.4|MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN|RHEA:11888 go.json NADP-acetaldehyde dehydrogenase activity|NADP-dependent aldehyde dehydrogenase activity|aldehyde:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033721 GO:0033720 biolink:MolecularActivity (S)-mandelate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor. EC:1.1.99.31|MetaCyc:MANDELATE-DEHYDROGENASE-RXN|RHEA:15749|UM-BBD_reactionID:r1048 go.json (S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity|L(+)-mandelate dehydrogenase activity|MDH http://purl.obolibrary.org/obo/GO_0033720 GO:0033718 biolink:MolecularActivity pyranose dehydrogenase (acceptor) activity Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor. EC:1.1.99.29|MetaCyc:RXN-7961|MetaCyc:RXN-7962|MetaCyc:RXN-7963|MetaCyc:RXN-7965|MetaCyc:RXN-7966 go.json PDH|pyranose dehydrogenase activity|pyranose-quinone oxidoreductase activity|pyranose:acceptor oxidoreductase activity|quinone-dependent pyranose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033718 GO:0033717 biolink:MolecularActivity gluconate 2-dehydrogenase (acceptor) activity Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor. EC:1.1.99.3|MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN|RHEA:12769 go.json 2-ketogluconate reductase activity|D-gluconate dehydrogenase activity|D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity|D-gluconate:(acceptor) 2-oxidoreductase activity|D-gluconate:acceptor 2-oxidoreductase activity|gluconate oxidase activity|gluconic acid dehydrogenase activity|gluconic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033717 GO:0033716 biolink:MolecularActivity nucleoside oxidase (hydrogen peroxide-forming) activity Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide. EC:1.1.3.39|MetaCyc:1.1.3.39-RXN|RHEA:15489 go.json nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity http://purl.obolibrary.org/obo/GO_0033716 GO:0043140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043140 GO:0033715 biolink:MolecularActivity nucleoside oxidase activity Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O. EC:1.1.3.28|MetaCyc:NUCLEOSIDE-OXIDASE-RXN|RHEA:28651 go.json nucleoside:oxygen 5'-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033715 GO:0033714 biolink:MolecularActivity secondary-alcohol oxidase activity Catalysis of the reaction: secondary alcohol + O2 = H2O2 + ketone. EC:1.1.3.18|KEGG_REACTION:R02277|MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN|RHEA:23180 go.json polyvinyl alcohol oxidase activity|secondary alcohol oxidase activity|secondary-alcohol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033714 GO:0008779 biolink:MolecularActivity acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. EC:2.3.1.40|MetaCyc:ACYLGPEACYLTRANS-RXN|RHEA:10304 go.json acyl-ACP-phospholipid O-acyltransferase activity|acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity|acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity|acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0008779 GO:0033713 biolink:MolecularActivity choline:oxygen 1-oxidoreductase activity Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide. EC:1.1.3.17|MetaCyc:CHOLINE-OXIDASE-RXN|RHEA:13505 go.json choline oxidase activity http://purl.obolibrary.org/obo/GO_0033713 GO:0033712 biolink:MolecularActivity 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH. EC:1.1.1.292|KEGG_REACTION:R08194|MetaCyc:1.1.1.292-RXN|RHEA:24208 go.json 1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity|AFR http://purl.obolibrary.org/obo/GO_0033712 GO:0008778 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008778 GO:0008777 biolink:MolecularActivity acetylornithine deacetylase activity Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine. EC:3.5.1.16|MetaCyc:ACETYLORNDEACET-RXN|RHEA:15941 go.json 2-N-acetyl-L-ornithine amidohydrolase activity|N-acetylornithinase activity|N2-acetyl-L-ornithine amidohydrolase activity|acetylornithinase activity http://purl.obolibrary.org/obo/GO_0008777 GO:0033711 biolink:MolecularActivity 4-phosphoerythronate dehydrogenase activity Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH. EC:1.1.1.290|KEGG_REACTION:R04210|MetaCyc:ERYTHRON4PDEHYDROG-RXN|RHEA:18829 go.json 4-O-phosphoerythronate dehydrogenase activity|4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity|4PE dehydrogenase activity|PdxB|PdxB 4PE dehydrogenase activity|erythronate-4-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033711 GO:0008776 biolink:MolecularActivity acetate kinase activity Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate. EC:2.7.2.1|MetaCyc:ACETATEKIN-RXN|RHEA:11352 go.json AK activity|ATP:acetate phosphotransferase activity|AckA|acetate kinase (phosphorylating) activity|acetic kinase activity|acetokinase activity http://purl.obolibrary.org/obo/GO_0008776 GO:0043146 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043146 GO:0008775 biolink:MolecularActivity acetate CoA-transferase activity Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. EC:2.8.3.8|MetaCyc:ACECOATRANS-RXN|RHEA:13381|Reactome:R-HSA-2066788|UM-BBD_enzymeID:e0012 go.json acetate coenzyme A-transferase activity|acetyl-CoA:acetoacetate CoA transferase activity|acyl-CoA:acetate CoA-transferase activity|butyryl CoA:acetate CoA transferase activity|butyryl coenzyme A transferase activity|succinyl-CoA:acetate CoA transferase activity http://purl.obolibrary.org/obo/GO_0008775 GO:0043145 biolink:BiologicalProcess sno(s)RNA 3'-end cleavage The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional. go.json sRNA 3'-end cleavage|sno(s)RNA 3' end cleavage|snoRNA 3'-end cleavage http://purl.obolibrary.org/obo/GO_0043145 GO:0043148 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043148 GO:0008774 biolink:MolecularActivity acetaldehyde dehydrogenase (acetylating) activity Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+. EC:1.2.1.10|MetaCyc:ACETALD-DEHYDROG-RXN|RHEA:23288 go.json ADA|DmpF|acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)|acylating acetaldehyde dehydrogenase activity|aldehyde dehydrogenase (acylating) activity http://purl.obolibrary.org/obo/GO_0008774 GO:0008773 biolink:MolecularActivity [protein-PII] uridylyltransferase activity Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). EC:2.7.7.59|MetaCyc:URITRANS-RXN|RHEA:13673 go.json PII uridylyl-transferase activity|UTP:[protein-PII] uridylyltransferase activity|UTP:protein-PII uridylyltransferase activity|protein-PII uridylyltransferase activity|uridyl removing enzyme|uridylyl removing enzyme activity http://purl.obolibrary.org/obo/GO_0008773 GO:0043147 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043147 GO:0008772 biolink:MolecularActivity [isocitrate dehydrogenase (NADP+)] kinase activity Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate. EC:2.7.11.5|MetaCyc:PHOSICITDEHASE-RXN|RHEA:43540 go.json ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity|ICDH kinase/phosphatase activity|IDH kinase activity|IDH kinase/phosphatase activity|IDH-K/P|IDHK/P|isocitrate dehydrogenase (NADP) kinase activity|isocitrate dehydrogenase (NADP+) kinase activity|isocitrate dehydrogenase kinase (phosphorylating) activity|isocitrate dehydrogenase kinase activity|isocitrate dehydrogenase kinase/phosphatase activity http://purl.obolibrary.org/obo/GO_0008772 GO:0043142 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043142 GO:0008771 biolink:MolecularActivity [citrate (pro-3S)-lyase] ligase activity Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form). EC:6.2.1.22|KEGG_REACTION:R04449|MetaCyc:CITC-RXN|RHEA:23788 go.json acetate: SH-acyl-carrier-protein enzyme ligase (AMP)|acetate:HS-citrate lyase ligase activity|acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)|citrate (pro-3S)-lyase ligase activity|citrate lyase ligase activity|citrate lyase synthetase activity http://purl.obolibrary.org/obo/GO_0008771 GO:0043141 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043141 GO:0008770 biolink:MolecularActivity [acyl-carrier-protein] phosphodiesterase activity Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. EC:3.1.4.14|MetaCyc:3.1.4.14-RXN|RHEA:20537 go.json ACP hydrolyase activity|ACP phosphodiesterase activity|AcpH|[acyl-carrier protein] phosphodiesterase activity|[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity|acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity|acyl-carrier-protein phosphodiesterase activity|holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008770 GO:0043144 biolink:BiologicalProcess sno(s)RNA processing Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea). go.json http://purl.obolibrary.org/obo/GO_0043144 goslim_yeast GO:0033719 biolink:MolecularActivity 2-oxo-acid reductase activity Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor. EC:1.1.99.30|MetaCyc:1.1.99.30-RXN|RHEA:23664 go.json (2R)-hydroxy-carboxylate:acceptor oxidoreductase activity|(2R)-hydroxycarboxylate-viologen-oxidoreductase activity|2-oxoacid reductase activity|HVOR http://purl.obolibrary.org/obo/GO_0033719 GO:0043143 biolink:BiologicalProcess regulation of translation by machinery localization Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. go.json establishment and maintenance of translational machinery localization|establishment and maintenance of translational protein localization|regulation of translation by machinery localisation|translational machinery localization|translational protein localization http://purl.obolibrary.org/obo/GO_0043143 GO:0043149 biolink:BiologicalProcess stress fiber assembly The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. go.json actin cable assembly|actin cable formation|stress fibre biosynthesis|stress fibre formation http://purl.obolibrary.org/obo/GO_0043149 GO:0033710 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033710 GO:0033707 biolink:MolecularActivity 3''-deamino-3''-oxonicotianamine reductase activity Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+. EC:1.1.1.285|MetaCyc:1.1.1.285-RXN go.json 2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033707 GO:0033706 biolink:MolecularActivity obsolete quinate/shikimate dehydrogenase activity OBSOLETE. Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+. go.json L-quinate:NAD(P)+ 3-oxidoreductase activity|YdiB|quinate/shikimate dehydrogenase activity True http://purl.obolibrary.org/obo/GO_0033706 GO:0033705 biolink:MolecularActivity GDP-4-dehydro-6-deoxy-D-mannose reductase activity Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. EC:1.1.1.281|MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN go.json GDP-4-keto-6-deoxy-D-mannose reductase activity|GDP-6-deoxy-D-lyxo-4-hexulose reductase activity|GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity|Rmd http://purl.obolibrary.org/obo/GO_0033705 GO:0008749 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008749 GO:0043151 biolink:BiologicalProcess DNA synthesis involved in double-strand break repair via single-strand annealing The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing. go.json DNA synthesis during double-strand break repair via single-strand annealing http://purl.obolibrary.org/obo/GO_0043151 GO:0008748 biolink:MolecularActivity N-ethylmaleimide reductase activity Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+. MetaCyc:RXN0-5101|RHEA:35523 go.json http://purl.obolibrary.org/obo/GO_0008748 GO:0033704 biolink:MolecularActivity 3beta-hydroxy-5alpha-steroid dehydrogenase activity Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH. EC:1.1.1.278|KEGG_REACTION:R07138|MetaCyc:1.1.1.278-RXN|RHEA:18137 go.json 3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033704 GO:0043150 biolink:BiologicalProcess DNA synthesis involved in double-strand break repair via homologous recombination The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination. go.json DNA synthesis during double-strand break repair via homologous recombination http://purl.obolibrary.org/obo/GO_0043150 GO:0008747 biolink:MolecularActivity N-acetylneuraminate lyase activity Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. EC:4.1.3.3|KEGG_REACTION:R01811|MetaCyc:RXN0-7390|RHEA:23296|Reactome:R-HSA-4085217 go.json N-acetylneuraminate aldolase activity|N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)|N-acetylneuraminate pyruvate-lyase activity|N-acetylneuraminic acid aldolase activity|N-acetylneuraminic acid lyase activity|N-acetylneuraminic aldolase activity|N-acetylneuraminic lyase activity|NALase activity|NANA lyase activity|NPL|acetylneuraminate lyase activity|acetylneuraminate pyruvate-lyase activity|neuraminate aldolase activity|neuraminic acid aldolase activity|neuraminic aldolase activity|sialate lyase activity|sialic acid aldolase activity|sialic aldolase activity http://purl.obolibrary.org/obo/GO_0008747 GO:0033703 biolink:MolecularActivity 3beta-hydroxy-5beta-steroid dehydrogenase activity Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH. EC:1.1.1.277|KEGG_REACTION:R06166|MetaCyc:1.1.1.277-RXN|RHEA:22944 go.json 3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity|3beta-hydroxysteroid 5beta-oxidoreductase activity|3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033703 GO:0008746 biolink:MolecularActivity NAD(P)+ transhydrogenase activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. EC:1.6.1.1|KEGG_REACTION:R00112|RHEA:11692|Reactome:R-HSA-450971 go.json H+-thase|NAD transhydrogenase|NADH transhydrogenase|NADH-NADP-transhydrogenase|NADPH-NAD oxidoreductase|NADPH-NAD transhydrogenase|NADPH:NAD+ transhydrogenase|energy-linked transhydrogenase|nicotinamide adenine dinucleotide (phosphate) transhydrogenase|pyridine nucleotide transferase http://purl.obolibrary.org/obo/GO_0008746 GO:0033702 biolink:MolecularActivity (+)-trans-carveol dehydrogenase activity Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH. EC:1.1.1.275|KEGG_REACTION:R06117|MetaCyc:RXN-9397|RHEA:14825 go.json (+)-trans-carveol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033702 GO:0008745 biolink:MolecularActivity N-acetylmuramoyl-L-alanine amidase activity Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. EC:3.5.1.28|MetaCyc:3.4.24.32-RXN|Reactome:R-HSA-6799977 go.json N-acetylmuramic acid L-alanine amidase activity|N-acetylmuramoyl-L-alanine amidase type I|N-acetylmuramoyl-L-alanine amidase type II|N-acetylmuramyl-L-alanine amidase activity|N-acetylmuramylalanine amidase activity|N-acylmuramyl-L-alanine amidase activity|acetylmuramoyl-alanine amidase activity|acetylmuramyl-L-alanine amidase activity|acetylmuramyl-alanine amidase activity http://purl.obolibrary.org/obo/GO_0008745 GO:0033701 biolink:MolecularActivity dTDP-galactose 6-dehydrogenase activity Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+. EC:1.1.1.186|MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN|RHEA:12396 go.json dTDP-D-galactose:NADP+ 6-oxidoreductase activity|dTDPgalactose 6-dehydrogenase activity|thymidine-diphosphate-galactose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033701 GO:0008744 biolink:MolecularActivity L-xylulokinase activity Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate. EC:2.7.1.53|MetaCyc:LYXK-RXN|RHEA:18869 go.json ATP:L-xylulose 5-phosphotransferase activity|L-xylulokinase (phosphorylating)|L-xylulose kinase activity http://purl.obolibrary.org/obo/GO_0008744 GO:0033700 biolink:BiologicalProcess phospholipid efflux The directed movement of a phospholipid out of a cell or organelle. go.json phospholipid export http://purl.obolibrary.org/obo/GO_0033700 GO:0008743 biolink:MolecularActivity L-threonine 3-dehydrogenase activity Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH. EC:1.1.1.103|KEGG_REACTION:R01465|MetaCyc:THREODEHYD-RXN|RHEA:13161|Reactome:R-HSA-6798667 go.json L-threonine dehydrogenase activity|L-threonine:NAD+ oxidoreductase activity|threonine 3-dehydrogenase activity|threonine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008743 GO:0043157 biolink:BiologicalProcess response to cation stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. go.json http://purl.obolibrary.org/obo/GO_0043157 GO:0043156 biolink:BiologicalProcess obsolete chromatin remodeling in response to cation stress OBSOLETE. Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. go.json True http://purl.obolibrary.org/obo/GO_0043156 GO:0008742 biolink:MolecularActivity L-ribulose-phosphate 4-epimerase activity Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. EC:5.1.3.4|KEGG_REACTION:R05850|MetaCyc:RIBULPEPIM-RXN|RHEA:22368 go.json AraD|L-Ru5P|L-ribulose 5-phosphate 4-epimerase activity|L-ribulose-5-phosphate 4-epimerase|L-ru5P activity|phosphoribulose isomerase activity|ribulose phosphate 4-epimerase activity http://purl.obolibrary.org/obo/GO_0008742 GO:0008741 biolink:MolecularActivity ribulokinase activity Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. EC:2.7.1.16|MetaCyc:RIBULOKIN-RXN|RHEA:22072 go.json ATP:L(or D)-ribulose 5-phosphotransferase activity|L-ribulokinase activity|ribulokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0008741 GO:0043159 biolink:CellularComponent acrosomal matrix A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction. go.json http://purl.obolibrary.org/obo/GO_0043159 GO:0008740 biolink:MolecularActivity L-rhamnose isomerase activity Catalysis of the reaction: L-rhamnose = L-rhamnulose. EC:5.3.1.14|KEGG_REACTION:R02437|MetaCyc:RHAMNISOM-RXN|RHEA:23160 go.json L-rhamnose aldose-ketose-isomerase activity|L-rhamnose ketol-isomerase activity|rhamnose isomerase activity http://purl.obolibrary.org/obo/GO_0008740 GO:0043158 biolink:BiologicalProcess heterocyst development The cellular developmental process by which a cell becomes a heterocyst, a cell that carries out nitrogen fixation. This process involves changes to the cell wall, expression of nitrogenase and other proteins involved in nitrogen fixation, and degradation of photosystem II, which produces oxygen. This process is known to occur in some cyanobacteria. go.json heterocyst cell differentiation|heterocyst differentiation|heterocyst formation http://purl.obolibrary.org/obo/GO_0043158 GO:0043153 biolink:BiologicalProcess entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). go.json photoentrainment of circadian clock http://purl.obolibrary.org/obo/GO_0043153 GO:0043152 biolink:BiologicalProcess induction of bacterial agglutination Any process in which infecting bacteria are clumped together by a host organism. go.json http://purl.obolibrary.org/obo/GO_0043152 GO:0043155 biolink:BiologicalProcess negative regulation of photosynthesis, light reaction Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis. go.json down regulation of photosynthesis, light reaction|down-regulation of photosynthesis, light reaction|downregulation of photosynthesis, light reaction|inhibition of photosynthesis, light reaction http://purl.obolibrary.org/obo/GO_0043155 GO:0033709 biolink:MolecularActivity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+. KEGG_REACTION:R07144|MetaCyc:RXN-7972|RHEA:11868 go.json ARD1p|D-arabinitol dehydrogenase 1 activity|D-arabinitol:NADP+ dehydrogenase activity|NADP+-dependent D-arabinitol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0033709 GO:0043154 biolink:BiologicalProcess negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. go.json down regulation of caspase activity|down-regulation of caspase activity|downregulation of caspase activity|inhibition of caspase activation|inhibition of caspase activity|negative regulation of caspase activation|negative regulation of caspase activity http://purl.obolibrary.org/obo/GO_0043154 gocheck_do_not_annotate GO:0033708 biolink:MolecularActivity isocitrate-homoisocitrate dehydrogenase activity Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+. EC:1.1.1.286|MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN|MetaCyc:RXN-7970 go.json PH1722|homoisocitrate-isocitrate dehydrogenase activity|isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity http://purl.obolibrary.org/obo/GO_0033708 GO:0043160 biolink:CellularComponent acrosomal lumen The volume enclosed within the acrosome membrane. go.json http://purl.obolibrary.org/obo/GO_0043160 GO:0043162 biolink:BiologicalProcess ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. go.json ubiquitin-dependent protein breakdown via the multivesicular body pathway|ubiquitin-dependent protein catabolic process via the MVB pathway|ubiquitin-dependent protein catabolism via the MVB pathway|ubiquitin-dependent protein degradation via the multivesicular body pathway http://purl.obolibrary.org/obo/GO_0043162 GO:0043161 biolink:BiologicalProcess proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. go.json proteasomal pathway|proteasomal processing|proteasomal ubiquitin-dependent protein breakdown|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-dependent protein catabolism|proteasomal ubiquitin-dependent protein degradation|proteasome pathway http://purl.obolibrary.org/obo/GO_0043161 GO:0008759 biolink:MolecularActivity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. EC:3.5.1.108 go.json http://purl.obolibrary.org/obo/GO_0008759 GO:0008758 biolink:MolecularActivity UDP-2,3-diacylglucosamine hydrolase activity Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. MetaCyc:LIPIDXSYNTHESIS-RXN|RHEA:25213 go.json http://purl.obolibrary.org/obo/GO_0008758 GO:0008757 biolink:MolecularActivity S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. go.json S-adenosyl methionine-dependent methyltransferase activity|SAM-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0008757 GO:0008756 biolink:MolecularActivity o-succinylbenzoate-CoA ligase activity Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. EC:6.2.1.26|KEGG_REACTION:R04030|MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN|RHEA:17009 go.json 2-succinylbenzoate:CoA ligase (AMP-forming)|OSB-CoA synthetase activity|o-succinylbenzoate:CoA ligase (AMP-forming)|o-succinylbenzoyl-CoA synthetase activity|o-succinylbenzoyl-coenzyme A synthetase activity http://purl.obolibrary.org/obo/GO_0008756 GO:0008755 biolink:MolecularActivity O antigen polymerase activity Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide. go.json O-antigen polymerase activity http://purl.obolibrary.org/obo/GO_0008755 GO:0008754 biolink:MolecularActivity O antigen ligase activity Catalysis of the reaction: Lipid A-core + colanic acid = MLPS. MetaCyc:RXN0-5294 go.json http://purl.obolibrary.org/obo/GO_0008754 GO:0043168 biolink:MolecularActivity anion binding Binding to an anion, a charged atom or group of atoms with a net negative charge. go.json http://purl.obolibrary.org/obo/GO_0043168 GO:0008753 biolink:MolecularActivity NADPH dehydrogenase (quinone) activity Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol. EC:1.6.5.10|KEGG_REACTION:R07359|MetaCyc:RXN0-271|RHEA:46164 go.json NADPH oxidase|NADPH:(quinone-acceptor) oxidoreductase|reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase http://purl.obolibrary.org/obo/GO_0008753 GO:0043167 biolink:MolecularActivity ion binding Binding to an ion, a charged atoms or groups of atoms. go.json atom binding http://purl.obolibrary.org/obo/GO_0043167 goslim_chembl|goslim_metagenomics|goslim_pir|goslim_yeast GO:0008752 biolink:MolecularActivity FMN reductase (NAD(P)H) activity Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates. EC:1.5.1.39|RHEA:21620|RHEA:21624 go.json FMN reductase activity|NAD(P)H dehydrogenase (FMN) activity|NAD(P)H-dependent FMN reductase activity|flavin mononucleotide reductase activity http://purl.obolibrary.org/obo/GO_0008752 GO:0008751 biolink:MolecularActivity obsolete NAD(P)H dehydrogenase OBSOLETE. (Was not defined before being made obsolete). go.json NAD(P)H dehydrogenase True http://purl.obolibrary.org/obo/GO_0008751 GO:0043169 biolink:MolecularActivity cation binding Binding to a cation, a charged atom or group of atoms with a net positive charge. go.json http://purl.obolibrary.org/obo/GO_0043169 GO:0043164 biolink:BiologicalProcess Gram-negative-bacterium-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. go.json 1-2nm peptidoglycan-based cell wall biogenesis|cell wall anabolism|cell wall assembly|cell wall biosynthetic process|cell wall formation|cell wall synthesis http://purl.obolibrary.org/obo/GO_0043164 GO:0008750 biolink:MolecularActivity NAD(P)+ transhydrogenase (AB-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. EC:1.6.1.2|MetaCyc:PYRNUTRANSHYDROGEN-RXN go.json NAD(P) transhydrogenase (AB-specific) activity|NADPH:NAD+ oxidoreductase (AB-specific)|pyridine nucleotide transhydrogenase activity|transhydrogenase activity http://purl.obolibrary.org/obo/GO_0008750 GO:0043163 biolink:BiologicalProcess cell envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present. go.json cell envelope organisation|cell envelope organization and biogenesis http://purl.obolibrary.org/obo/GO_0043163 goslim_pir GO:0043166 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043166 GO:0043165 biolink:BiologicalProcess Gram-negative-bacterium-type cell outer membrane assembly The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. go.json cell outer membrane biogenesis http://purl.obolibrary.org/obo/GO_0043165 GO:0102001 biolink:MolecularActivity isoleucine N-monooxygenase (oxime forming) activity Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O. EC:1.14.14.39|MetaCyc:1.14.13.117-RXN|RHEA:28602 go.json http://purl.obolibrary.org/obo/GO_0102001 GO:0102003 biolink:MolecularActivity Delta8-sphingolipid desaturase activity Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor = 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor. EC:1.14.19.4|MetaCyc:1.14.19.4-RXN go.json http://purl.obolibrary.org/obo/GO_0102003 GO:0102002 biolink:MolecularActivity valine N-monooxygenase (oxime forming) activity Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O. EC:1.14.14.38|MetaCyc:1.14.13.118-RXN|RHEA:28606 go.json http://purl.obolibrary.org/obo/GO_0102002 GO:0102005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102005 GO:0102004 biolink:MolecularActivity 2-octaprenyl-6-hydroxyphenol methylase activity Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine. MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN|RHEA:27770 go.json http://purl.obolibrary.org/obo/GO_0102004 GO:0102007 biolink:MolecularActivity acyl-L-homoserine-lactone lactonohydrolase activity Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine. EC:3.1.1.81|MetaCyc:3.1.1.81-RXN|RHEA:22576|Reactome:R-HSA-8932633|Reactome:R-HSA-9756136|Reactome:R-HSA-9756150|Reactome:R-HSA-9756177 go.json http://purl.obolibrary.org/obo/GO_0102007 GO:0102006 biolink:MolecularActivity 4-methyl-2-oxopentanoate dehydrogenase activity Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) = isovaleryl-CoA(4-) + carbon dioxide + NADH(2-). MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN|RHEA:25177 go.json http://purl.obolibrary.org/obo/GO_0102006 GO:0102009 biolink:MolecularActivity proline dipeptidase activity Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid. EC:3.4.13.9|MetaCyc:3.4.13.9-RXN go.json http://purl.obolibrary.org/obo/GO_0102009 GO:0102008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102008 GO:0018193 biolink:BiologicalProcess peptidyl-amino acid modification The alteration of an amino acid residue in a peptide. go.json http://purl.obolibrary.org/obo/GO_0018193 gocheck_do_not_annotate|goslim_yeast GO:0018192 biolink:BiologicalProcess obsolete enzyme active site formation via cysteine modification to L-cysteine persulfide OBSOLETE. The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide. go.json enzyme active site formation via L-cysteine persulphide True http://purl.obolibrary.org/obo/GO_0018192 GO:0018195 biolink:BiologicalProcess peptidyl-arginine modification The modification of peptidyl-arginine. go.json http://purl.obolibrary.org/obo/GO_0018195 gocheck_do_not_annotate GO:0018194 biolink:BiologicalProcess peptidyl-alanine modification The modification of peptidyl-alanine. go.json http://purl.obolibrary.org/obo/GO_0018194 gocheck_do_not_annotate GO:0018191 biolink:BiologicalProcess peptidyl-serine octanoylation The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin. RESID:AA0290 go.json http://purl.obolibrary.org/obo/GO_0018191 gocheck_do_not_annotate GO:0018190 biolink:BiologicalProcess protein octanoylation The modification of a protein amino acid by formation of an ester or amide with octanoic acid. go.json protein amino acid octanoylation http://purl.obolibrary.org/obo/GO_0018190 gocheck_do_not_annotate GO:0102014 biolink:MolecularActivity beta-D-galactose-importing ATPase activity Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O = ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+. MetaCyc:ABC-18-RXN|RHEA:30011 go.json http://purl.obolibrary.org/obo/GO_0102014 GO:0102013 biolink:MolecularActivity ATPase-coupled L-glutamate tranmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in). MetaCyc:ABC-13-RXN go.json L-glutamate-importing ATPase activity http://purl.obolibrary.org/obo/GO_0102013 GO:0102016 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102016 GO:0102017 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102017 GO:0018189 biolink:BiologicalProcess pyrroloquinoline quinone biosynthetic process The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. RESID:AA0283 go.json PQQ biosynthesis|PQQ biosynthetic process|coenzyme pyrroloquinoline-quinone biosynthesis|coenzyme pyrroloquinoline-quinone biosynthetic process|pyrroloquinoline quinone anabolism|pyrroloquinoline quinone biosynthesis|pyrroloquinoline quinone formation|pyrroloquinoline quinone synthesis|pyrroloquinoline-quinone biosynthesis|pyrroloquinoline-quinone biosynthetic process http://purl.obolibrary.org/obo/GO_0018189 GO:0018186 biolink:BiologicalProcess peroxidase-heme linkage The covalent linkage of heme to peroxidase. RESID:AA0279|RESID:AA0280 go.json peroxidase-haem linkage http://purl.obolibrary.org/obo/GO_0018186 gocheck_do_not_annotate GO:0018185 biolink:BiologicalProcess poly-N-methyl-propylamination The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin. RESID:AA0278 go.json http://purl.obolibrary.org/obo/GO_0018185 gocheck_do_not_annotate GO:0018188 biolink:BiologicalProcess peptidyl-proline di-hydroxylation The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline. RESID:AA0282 go.json http://purl.obolibrary.org/obo/GO_0018188 gocheck_do_not_annotate GO:0018187 biolink:BiologicalProcess molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide. RESID:AA0281 go.json http://purl.obolibrary.org/obo/GO_0018187 gocheck_do_not_annotate GO:0102023 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102023 GO:0102022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102022 GO:0102025 biolink:MolecularActivity ABC-type thiosulfate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in). EC:7.3.2.3|MetaCyc:ABC-7-RXN|RHEA:29871 go.json ATPase-coupled thiosulfate transmembrane transporter activity|thiosulfate transmembrane-transporting ATPase activity|thiosulphate ABC transporter activity http://purl.obolibrary.org/obo/GO_0102025 GO:0102027 biolink:MolecularActivity S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine = menaquinol-8 + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.163|MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN|RHEA:30063 go.json http://purl.obolibrary.org/obo/GO_0102027 GO:0102026 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102026 GO:0102029 biolink:MolecularActivity D-lactate dehydrogenase (quinone) activity Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol. EC:1.1.5.12|MetaCyc:DLACTDEHYDROGFAD-RXN|RHEA:51468 go.json http://purl.obolibrary.org/obo/GO_0102029 GO:0102028 biolink:MolecularActivity cystathionine gamma-synthase activity (acts on O-phosphohomoserine) Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate. EC:2.5.1.48|MetaCyc:CYSPH-RXN go.json http://purl.obolibrary.org/obo/GO_0102028 GO:0018197 biolink:BiologicalProcess peptidyl-aspartic acid modification The modification of peptidyl-aspartic acid. go.json http://purl.obolibrary.org/obo/GO_0018197 gocheck_do_not_annotate GO:0018196 biolink:BiologicalProcess obsolete peptidyl-asparagine modification OBSOLETE. The modification of peptidyl-asparagine. go.json True http://purl.obolibrary.org/obo/GO_0018196 GO:0018199 biolink:BiologicalProcess peptidyl-glutamine modification The modification of peptidyl-glutamine. go.json http://purl.obolibrary.org/obo/GO_0018199 gocheck_do_not_annotate GO:0018198 biolink:BiologicalProcess peptidyl-cysteine modification The modification of peptidyl-cysteine. go.json http://purl.obolibrary.org/obo/GO_0018198 gocheck_do_not_annotate GO:0018171 biolink:BiologicalProcess peptidyl-cysteine oxidation The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid. RESID:AA0205|RESID:AA0262 go.json http://purl.obolibrary.org/obo/GO_0018171 gocheck_do_not_annotate GO:0018170 biolink:BiologicalProcess obsolete C-terminal peptidyl-polyglutamic acid amidation OBSOLETE. The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus. RESID:AA0261 go.json True http://purl.obolibrary.org/obo/GO_0018170 GO:0018173 biolink:BiologicalProcess peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine. RESID:AA0265 go.json peptidyl-1-thioglycine anabolism from peptidyl-glycine|peptidyl-1-thioglycine formation from peptidyl-glycine|peptidyl-1-thioglycine synthesis from peptidyl-glycine http://purl.obolibrary.org/obo/GO_0018173 gocheck_do_not_annotate GO:0018172 biolink:BiologicalProcess peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine. RESID:AA0263 go.json peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine|peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine|peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0018172 gocheck_do_not_annotate GO:0018168 biolink:BiologicalProcess protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine. RESID:AA0132 go.json http://purl.obolibrary.org/obo/GO_0018168 gocheck_do_not_annotate GO:0018167 biolink:BiologicalProcess protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine. RESID:AA0259 go.json http://purl.obolibrary.org/obo/GO_0018167 gocheck_do_not_annotate GO:0018169 biolink:MolecularActivity ribosomal S6-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. go.json http://purl.obolibrary.org/obo/GO_0018169 GO:0018164 biolink:BiologicalProcess protein-DNA covalent cross-linking via peptidyl-threonine The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine. RESID:AA0255 go.json DNA-protein covalent cross-linking via peptidyl-threonine http://purl.obolibrary.org/obo/GO_0018164 gocheck_do_not_annotate GO:0018163 biolink:BiologicalProcess protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine. RESID:AA0254 go.json DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0018163 gocheck_do_not_annotate GO:0018166 biolink:BiologicalProcess obsolete C-terminal protein-tyrosinylation OBSOLETE. The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase. RESID:AA0257 go.json True http://purl.obolibrary.org/obo/GO_0018166 GO:0018165 biolink:BiologicalProcess peptidyl-tyrosine uridylylation The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase. RESID:AA0256 go.json http://purl.obolibrary.org/obo/GO_0018165 gocheck_do_not_annotate GO:0018182 biolink:BiologicalProcess protein-heme linkage via 3'-L-histidine The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine). RESID:AA0276 go.json protein-haem linkage via 3'-L-histidine http://purl.obolibrary.org/obo/GO_0018182 gocheck_do_not_annotate GO:0018181 biolink:BiologicalProcess obsolete peptidyl-arginine C5-methylation OBSOLETE. The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine. go.json peptidyl-arginine 5-methylation True http://purl.obolibrary.org/obo/GO_0018181 GO:0018184 biolink:BiologicalProcess protein polyamination The modification of a protein amino acid by polyamination. go.json protein amino acid polyamination http://purl.obolibrary.org/obo/GO_0018184 gocheck_do_not_annotate GO:0018183 biolink:BiologicalProcess obsolete enzyme active site formation via S-selenyl-L-cysteine OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine. go.json enzyme active site formation via S-selenyl-L-cysteine True http://purl.obolibrary.org/obo/GO_0018183 GO:0018180 biolink:BiologicalProcess protein desulfurization The removal of a sulfur group from a protein amino acid. go.json protein amino acid desulfurisation|protein amino acid desulfurization|protein amino acid desulphurisation|protein amino acid desulphurization http://purl.obolibrary.org/obo/GO_0018180 gocheck_do_not_annotate GO:0033799 biolink:MolecularActivity myricetin 3'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin. EC:2.1.1.267|KEGG_REACTION:R06815|MetaCyc:RXN-13912|MetaCyc:RXN-8451|RHEA:25629 go.json CrCOMT2|S-adenosyl-L-methionine:myricetin O-methyltransferase activity|flavonoid 3',5'-O-dimethyltransferase activity|myricetin 3-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0033799 GO:0033790 biolink:MolecularActivity hydroxymethylfurfural reductase activity Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+. go.json http://purl.obolibrary.org/obo/GO_0033790 GO:0033798 biolink:MolecularActivity thyroxine 5-deiodinase activity Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2. EC:1.21.99.3|MetaCyc:1.97.1.11-RXN|RHEA:18897 go.json acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity|diiodothyronine 5'-deiodinase activity|inner ring-deiodinating pathway|iodothyronine 5-deiodinase activity|iodothyronine inner ring monodeiodinase activity|type III iodothyronine deiodinase activity http://purl.obolibrary.org/obo/GO_0033798 GO:0018179 biolink:BiologicalProcess obsolete peptidyl-cysteine desulfurization OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate. RESID:AA0269 go.json peptidyl-cysteine desulfurization|peptidyl-cysteine desulphurization True http://purl.obolibrary.org/obo/GO_0018179 GO:0033797 biolink:MolecularActivity selenate reductase activity Catalysis of the reaction: 2 e(-) + 2 H+ + selenate = H2O + selenite. EC:1.97.1.9|KEGG_REACTION:R07229|MetaCyc:RXN0-2101|RHEA:14029|UM-BBD_reactionID:r0828 go.json selenite:reduced acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033797 GO:0018178 biolink:BiologicalProcess peptidyl-threonine adenylylation The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine. RESID:AA0267 go.json peptidyl-threonine adenylation http://purl.obolibrary.org/obo/GO_0018178 gocheck_do_not_annotate GO:0033796 biolink:MolecularActivity sulfur reductase activity Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide. EC:1.12.98.4|MetaCyc:RXN-8269|RHEA:35591 go.json (donor):sulfur oxidoreductase activity|sulphur reductase activity http://purl.obolibrary.org/obo/GO_0033796 GO:0033795 biolink:MolecularActivity betaine reductase activity Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin. EC:1.21.4.4|RHEA:11848 go.json acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity http://purl.obolibrary.org/obo/GO_0033795 GO:0018175 biolink:BiologicalProcess protein nucleotidylation The addition of a nucleotide to a protein amino acid. go.json protein amino acid nucleotidylation http://purl.obolibrary.org/obo/GO_0018175 gocheck_do_not_annotate GO:0033794 biolink:MolecularActivity sarcosine reductase activity Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin. EC:1.21.4.3|RHEA:12825 go.json acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity http://purl.obolibrary.org/obo/GO_0033794 GO:0018174 biolink:BiologicalProcess protein-heme P460 linkage The linkage of protein to heme P460. RESID:AA0266|RESID:AA0271 go.json protein-haem P460 linkage http://purl.obolibrary.org/obo/GO_0018174 gocheck_do_not_annotate GO:0033793 biolink:MolecularActivity aureusidin synthase activity Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O. go.json 2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033793 GO:0033792 biolink:MolecularActivity 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH. EC:1.1.1.395|RHEA:55380 go.json 7alpha-dehydroxylase activity|bile acid 7-dehydroxylase activity|bile-acid 7alpha-dehydroxylase activity|cholate 7alpha-dehydroxylase activity http://purl.obolibrary.org/obo/GO_0033792 GO:0018177 biolink:BiologicalProcess protein uridylylation The addition of phospho-uridine to a protein amino acid. go.json protein amino acid uridylylation http://purl.obolibrary.org/obo/GO_0018177 gocheck_do_not_annotate GO:0033791 biolink:MolecularActivity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor. EC:1.17.99.3|MetaCyc:1.17.99.3-RXN|RHEA:15733 go.json (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity|THC-CoA oxidase activity|THCA-CoA oxidase activity|trihydroxycoprostanoyl-CoA oxidase activity http://purl.obolibrary.org/obo/GO_0033791 GO:0018176 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018176 GO:0018151 biolink:BiologicalProcess peptide cross-linking via L-histidyl-L-tyrosine The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link. go.json http://purl.obolibrary.org/obo/GO_0018151 gocheck_do_not_annotate GO:0018150 biolink:BiologicalProcess peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link. RESID:AA0250 go.json http://purl.obolibrary.org/obo/GO_0018150 gocheck_do_not_annotate GO:0033789 biolink:MolecularActivity phenylacetyl-CoA dehydrogenase activity Catalysis of the reaction: 2 1,4-benzoquinone + H2O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA. EC:1.17.5.1|KEGG_REACTION:R07222|MetaCyc:1.17.5.1-RXN|RHEA:15705 go.json phenylacetyl-CoA:acceptor oxidoreductase activity|phenylacetyl-CoA:quinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033789 GO:0033788 biolink:MolecularActivity leucoanthocyanidin reductase activity Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+. EC:1.17.1.3|MetaCyc:RXN-1484|RHEA:10616 go.json (2R,3S)-catechin:NADP+ 4-oxidoreductase activity|leucocyanidin reductase activity http://purl.obolibrary.org/obo/GO_0033788 GO:0018149 biolink:BiologicalProcess peptide cross-linking The formation of a covalent cross-link between or within protein chains. go.json http://purl.obolibrary.org/obo/GO_0018149 gocheck_do_not_annotate GO:0033787 biolink:MolecularActivity cyanocobalamin reductase (cyanide-eliminating) activity Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH. EC:1.16.1.6|KEGG_REACTION:R02999|MetaCyc:1.6.99.12-RXN|RHEA:16113|Reactome:R-HSA-3149519 go.json NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity|NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity|cob(I)alamin, cyanide:NADP+ oxidoreductase activity|cyanocobalamin reductase (NADPH, cyanide-eliminating) activity|cyanocobalamin reductase (NADPH; CN-eliminating) activity|cyanocobalamin reductase activity http://purl.obolibrary.org/obo/GO_0033787 GO:0018146 biolink:BiologicalProcess keratan sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. RESID:AA0247 go.json keratan sulfate anabolism|keratan sulfate biosynthesis|keratan sulfate formation|keratan sulfate synthesis|keratan sulphate biosynthesis|keratan sulphate biosynthetic process http://purl.obolibrary.org/obo/GO_0018146 GO:0018145 biolink:BiologicalProcess protein-DNA covalent cross-linking via peptidyl-serine The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine. RESID:AA0246 go.json DNA-protein covalent cross-linking via peptidyl-serine http://purl.obolibrary.org/obo/GO_0018145 gocheck_do_not_annotate GO:0033786 biolink:MolecularActivity heptose-1-phosphate adenylyltransferase activity Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose. MetaCyc:RXN0-4342|RHEA:27465 go.json D-beta-D-heptose 1-phosphate adenylyltransferase activity|heptose 1-phosphate adenyltransferase activity http://purl.obolibrary.org/obo/GO_0033786 GO:0033785 biolink:MolecularActivity heptose 7-phosphate kinase activity Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP. EC:2.7.1.167|MetaCyc:RXN0-4341|RHEA:27473 go.json D-alpha,beta-D-heptose 7-phosphate 1-kinase activity http://purl.obolibrary.org/obo/GO_0033785 GO:0018148 biolink:BiologicalProcess RNA-protein covalent cross-linking via peptidyl-tyrosine The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine. RESID:AA0249 go.json http://purl.obolibrary.org/obo/GO_0018148 gocheck_do_not_annotate GO:0018147 biolink:BiologicalProcess molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). RESID:AA0248 go.json http://purl.obolibrary.org/obo/GO_0018147 gocheck_do_not_annotate GO:0033784 biolink:MolecularActivity senecionine N-oxygenase activity Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide. EC:1.14.13.101|KEGG_REACTION:R07373|MetaCyc:1.14.13.101-RXN|RHEA:11420 go.json SNO|senecionine monooxygenase (N-oxide-forming) activity|senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity http://purl.obolibrary.org/obo/GO_0033784 GO:0033783 biolink:MolecularActivity 25-hydroxycholesterol 7alpha-hydroxylase activity Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O. EC:1.14.14.29|MetaCyc:RXN-7980|MetaCyc:RXN-7981|RHEA:19041 go.json 25-hydroxycholesterol 7alpha-monooxygenase activity|CYP7B1|CYP7B1 oxysterol 7alpha-hydroxylase activity|cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0033783 GO:0018142 biolink:BiologicalProcess protein-DNA covalent cross-linking The formation of a covalent cross-link between DNA and a protein. go.json DNA-protein covalent cross-linking http://purl.obolibrary.org/obo/GO_0018142 gocheck_do_not_annotate GO:0033782 biolink:MolecularActivity 24-hydroxycholesterol 7alpha-hydroxylase activity Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.26|KEGG_REACTION:R07208|MetaCyc:1.14.13.99-RXN|RHEA:46124 go.json 24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity|24-hydroxycholesterol 7alpha-monooxygenase activity http://purl.obolibrary.org/obo/GO_0033782 GO:0018141 biolink:BiologicalProcess peptide cross-linking via L-lysine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. RESID:AA0245 go.json http://purl.obolibrary.org/obo/GO_0018141 gocheck_do_not_annotate GO:0033781 biolink:MolecularActivity cholesterol 24-hydroxylase activity Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+. EC:1.14.14.25|KEGG_REACTION:R07207|MetaCyc:1.14.13.98-RXN|RHEA:22716|Reactome:R-HSA-192061 go.json CYP46|CYP46A1|cholesterol 24-monooxygenase activity|cholesterol 24S-hydroxylase activity|cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity|cytochrome P450 46A1 http://purl.obolibrary.org/obo/GO_0033781 GO:0018144 biolink:BiologicalProcess RNA-protein covalent cross-linking The formation of a covalent cross-link between RNA and a protein. go.json http://purl.obolibrary.org/obo/GO_0018144 gocheck_do_not_annotate GO:0033780 biolink:MolecularActivity taurochenodeoxycholate 6alpha-hydroxylase activity Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O. EC:1.14.14.57|MetaCyc:RXN-7977|RHEA:23644 go.json CYP3A4|CYP4A21|taurochenodeoxycholate 6alpha-monooxygenase activity|taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0033780 GO:0018143 biolink:BiologicalProcess nucleic acid-protein covalent cross-linking The formation of a covalent cross-link between a nucleic acid and a protein. go.json http://purl.obolibrary.org/obo/GO_0018143 gocheck_do_not_annotate GO:0018160 biolink:BiologicalProcess peptidyl-pyrromethane cofactor linkage The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. RESID:AA0252 go.json dipyrromethane cofactor binding|peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine http://purl.obolibrary.org/obo/GO_0018160 gocheck_do_not_annotate GO:0018162 biolink:BiologicalProcess peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine. RESID:AA0253 go.json http://purl.obolibrary.org/obo/GO_0018162 gocheck_do_not_annotate GO:0018161 biolink:BiologicalProcess dipyrrin biosynthetic process The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. go.json dipyrrin anabolism|dipyrrin biosynthesis|dipyrrin formation|dipyrrin synthesis|dipyrromethane biosynthesis|dipyrromethane biosynthetic process http://purl.obolibrary.org/obo/GO_0018161 GO:0033779 biolink:MolecularActivity 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+. KEGG_REACTION:R07204|MetaCyc:1.14.13.96-RXN|RHEA:15261 go.json 5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity|5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0033779 GO:0033778 biolink:MolecularActivity 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+. KEGG_REACTION:R04826|MetaCyc:1.14.13.95-RXN|RHEA:46752|Reactome:R-HSA-192157|Reactome:R-HSA-193709|Reactome:R-HSA-193845 go.json 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity http://purl.obolibrary.org/obo/GO_0033778 GO:0033777 biolink:MolecularActivity lithocholate 6beta-hydroxylase activity Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+. EC:1.14.14.138|KEGG_REACTION:R07203|MetaCyc:1.14.13.94-RXN|RHEA:18857 go.json 6beta-hydroxylase activity|CYP3A10|cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity|lithocholate 6beta-monooxygenase activity|lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0033777 GO:0033776 biolink:MolecularActivity phenylacetone monooxygenase activity Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+. EC:1.14.13.92|KEGG_REACTION:R07201|MetaCyc:1.14.13.92-RXN|RHEA:10124 go.json PAMO|phenylacetone,NADPH:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033776 GO:0018157 biolink:BiologicalProcess peptide cross-linking via an oxazole or thiazole The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. go.json peptide heterocycle biosynthesis|peptide heterocycle biosynthetic process|peptide heterocycle formation|peptide heterocycle synthesis http://purl.obolibrary.org/obo/GO_0018157 gocheck_do_not_annotate GO:0033775 biolink:MolecularActivity deoxysarpagine hydroxylase activity Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine. EC:1.14.14.136|KEGG_REACTION:R05828|MetaCyc:1.14.13.91-RXN|RHEA:14237 go.json 10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity|DOSH http://purl.obolibrary.org/obo/GO_0033775 GO:0018156 biolink:BiologicalProcess peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine). RESID:AA0112 go.json http://purl.obolibrary.org/obo/GO_0018156 gocheck_do_not_annotate GO:0018159 biolink:BiologicalProcess peptidyl-methionine oxidation The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone. RESID:AA0251 go.json http://purl.obolibrary.org/obo/GO_0018159 gocheck_do_not_annotate GO:0033774 biolink:CellularComponent basal labyrinth A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane. go.json http://purl.obolibrary.org/obo/GO_0033774 GO:0033773 biolink:MolecularActivity isoflavone 2'-hydroxylase activity Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.90|MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN|RHEA:18849 go.json CYP Ge-3|CYP81E1|isoflavone 2'-monooxygenase activity http://purl.obolibrary.org/obo/GO_0033773 GO:0018158 biolink:BiologicalProcess protein oxidation The modification of a protein amino acid by oxidation. go.json protein amino acid oxidation http://purl.obolibrary.org/obo/GO_0018158 gocheck_do_not_annotate GO:0033772 biolink:MolecularActivity flavonoid 3',5'-hydroxylase activity Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O. EC:1.14.14.81|MetaCyc:RXN-7783|MetaCyc:RXN-8671|RHEA:55448 go.json F3',5'H|F3'5'H|flavanone,NADPH:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0033772 GO:0018153 biolink:BiologicalProcess isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine. RESID:AA0124 go.json http://purl.obolibrary.org/obo/GO_0018153 gocheck_do_not_annotate GO:0018152 biolink:BiologicalProcess peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link. RESID:AA0270 go.json http://purl.obolibrary.org/obo/GO_0018152 gocheck_do_not_annotate GO:0033771 biolink:MolecularActivity flavanone 2-hydroxylase activity Catalysis of the reaction: a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. EC:1.14.14.162|KEGG_REACTION:R07198|MetaCyc:RXN-19645|RHEA:57584 go.json licodione synthase activity http://purl.obolibrary.org/obo/GO_0033771 GO:0033770 biolink:MolecularActivity 2-hydroxyisoflavanone synthase activity Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase]. EC:1.14.14.87|MetaCyc:RXN-1541|MetaCyc:RXN-3283|MetaCyc:RXN-7750 go.json isoflavonoid synthase http://purl.obolibrary.org/obo/GO_0033770 GO:0018155 biolink:BiologicalProcess peptide cross-linking via sn-(2S,6R)-lanthionine The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione). RESID:AA0111 go.json http://purl.obolibrary.org/obo/GO_0018155 gocheck_do_not_annotate GO:0018154 biolink:BiologicalProcess peptide cross-linking via (2R,6R)-lanthionine The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine). RESID:AA0110 go.json http://purl.obolibrary.org/obo/GO_0018154 gocheck_do_not_annotate GO:0102072 biolink:MolecularActivity obsolete 3-oxo-cis-Delta9-hexadecenoyl-[acp] reductase activity OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxy cis Delta9-hexadecenoyl-[acp] = NADPH + H+ + a 3-oxo-cis-Delta9-hexadecenoyl-[acp]. go.json True http://purl.obolibrary.org/obo/GO_0102072 GO:0102071 biolink:MolecularActivity 9,10-epoxy-18-hydroxystearate hydrolase activity Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O = 9,10,18-trihydroxystearate. MetaCyc:RXN-1065 go.json http://purl.obolibrary.org/obo/GO_0102071 GO:0102074 biolink:MolecularActivity obsolete OPC6-trans-2-enoyl-CoA hydratase activity OBSOLETE. Catalysis of the reaction: OPC6-3-hydroxyacyl-CoA = OPC6-trans-2-enoyl-CoA + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102074 GO:0102073 biolink:MolecularActivity obsolete OPC8-trans-2-enoyl-CoA hydratase activity OBSOLETE. Catalysis of the reaction: OPC8-3-hydroxyacyl-CoA = OPC8-trans-2-enoyl-CoA + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102073 GO:0102076 biolink:MolecularActivity beta,beta-carotene-9',10'-cleaving oxygenase activity Catalysis of the reaction: beta-carotene + O2 = 10'-apo-beta-carotenal + beta-ionone. EC:1.13.11.71|MetaCyc:RXN-10741|RHEA:26389 go.json http://purl.obolibrary.org/obo/GO_0102076 GO:0102075 biolink:MolecularActivity obsolete OPC4-trans-2-enoyl-CoA hydratase activity OBSOLETE. Catalysis of the reaction: OPC4-3-hydroxyacyl-CoA = OPC4-trans-2-enoyl-CoA + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102075 GO:0102078 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102078 GO:0102077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102077 GO:0102081 biolink:MolecularActivity homotaurine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) = 3-sulfopropanal + L-glutamate(1-). MetaCyc:RXN-10822 go.json http://purl.obolibrary.org/obo/GO_0102081 GO:0102080 biolink:MolecularActivity phenylacetyl-coenzyme A:glycine N-acyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + glycine = H+ + phenylacetylglycine + coenzyme A. EC:2.3.1.192|MetaCyc:RXN-10821|RHEA:27850 go.json http://purl.obolibrary.org/obo/GO_0102080 GO:0102083 biolink:MolecularActivity 7,8-dihydromonapterin aldolase activity Catalysis of the reaction: 7,8-dihydromonapterin = glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol. MetaCyc:RXN-10857 go.json http://purl.obolibrary.org/obo/GO_0102083 GO:0102082 biolink:MolecularActivity demethylrebeccamycin--D-glucose O-methyltransferase activity Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine = H+ + rebeccamycin + S-adenosyl-L-homocysteine. EC:2.1.1.164|MetaCyc:RXN-10847|RHEA:27353 go.json http://purl.obolibrary.org/obo/GO_0102082 GO:0102085 biolink:MolecularActivity N-(4-aminobenzoyl)-L-glutamate synthetase activity Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP = H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid. MetaCyc:RXN-10884 go.json http://purl.obolibrary.org/obo/GO_0102085 GO:0102084 biolink:MolecularActivity L-dopa O-methyltransferase activity Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine = 3-O-methyldopa + S-adenosyl-L-homocysteine + H+. EC:2.1.1.6|MetaCyc:RXN-10870 go.json http://purl.obolibrary.org/obo/GO_0102084 GO:0102087 biolink:MolecularActivity N-benzoyl-L-glutamate synthetase activity Catalysis of the reaction: benzoate + L-glutamate + ATP = H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid. MetaCyc:RXN-10886 go.json http://purl.obolibrary.org/obo/GO_0102087 GO:0102086 biolink:MolecularActivity N-vanillate-L-glutamate synthetase activity Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP = H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid. MetaCyc:RXN-10885 go.json http://purl.obolibrary.org/obo/GO_0102086 GO:0102089 biolink:MolecularActivity dehydroscoulerine synthase activity Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+. MetaCyc:RXN-10888 go.json http://purl.obolibrary.org/obo/GO_0102089 GO:0102088 biolink:MolecularActivity N-(4-hydroxybenzoyl)-L-glutamate synthetase activity Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP = H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid. MetaCyc:RXN-10887 go.json http://purl.obolibrary.org/obo/GO_0102088 GO:0102090 biolink:MolecularActivity adrenaline O-methyltransferase activity Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-10909 go.json http://purl.obolibrary.org/obo/GO_0102090 GO:0102092 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102092 GO:0102091 biolink:MolecularActivity phosphatidylinositol-5-phosphate phosphatase activity Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate. MetaCyc:RXN-10962 go.json phosphatidylinositol-5-phosphate 5-phosphatase activity http://purl.obolibrary.org/obo/GO_0102091 GO:0102094 biolink:MolecularActivity S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol = S-adenosyl-L-homocysteine + H+ + a menaquinol. EC:2.1.1.163|MetaCyc:RXN-11046|RHEA:26466 go.json http://purl.obolibrary.org/obo/GO_0102094 GO:0102093 biolink:MolecularActivity acrylate:acyl-coA CoA transferase activity Catalysis of the reaction: acryloyl-CoA + H2O = acrylate + coenzyme A + H+. MetaCyc:RXN-10985 go.json http://purl.obolibrary.org/obo/GO_0102093 GO:0102096 biolink:MolecularActivity decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+. EC:2.4.1.289|MetaCyc:RXN-11070|RHEA:34487 go.json http://purl.obolibrary.org/obo/GO_0102096 GO:0102098 biolink:MolecularActivity D-galacturonate reductase activity Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+. EC:1.1.1.365|MetaCyc:RXN-11151|RHEA:26345 go.json http://purl.obolibrary.org/obo/GO_0102098 GO:0102097 biolink:MolecularActivity (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ = 3-dehydro-6-deoxoteasterone + NADP + H2O. EC:1.14.14.147|MetaCyc:RXN-11101|RHEA:27325 go.json http://purl.obolibrary.org/obo/GO_0102097 GO:0102099 biolink:MolecularActivity FAD-dependent urate hydroxylase activity Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 = 5-hydroxyisouric acid + NAD + H2O. EC:1.14.13.113|MetaCyc:RXN-11186|RHEA:27329 go.json http://purl.obolibrary.org/obo/GO_0102099 GO:0102030 biolink:MolecularActivity dTDP-L-rhamnose synthetase activity Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+. MetaCyc:DTDPRHAMSYNTHMULTI-RXN go.json http://purl.obolibrary.org/obo/GO_0102030 GO:0102031 biolink:MolecularActivity 4-acetamido-4,6-dideoxy-D-galactose transferase activity Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol = H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP. EC:2.4.1.325|MetaCyc:FUC4NACTRANS-RXN|RHEA:28759 go.json http://purl.obolibrary.org/obo/GO_0102031 GO:0102033 biolink:MolecularActivity long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. EC:1.14.14.80|MetaCyc:RXN-16394|RHEA:56748 go.json cytochrome P450 fatty acid omega-hydroxylase activity http://purl.obolibrary.org/obo/GO_0102033 GO:0102036 biolink:MolecularActivity methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] = an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]. EC:2.1.1.258|MetaCyc:METHCOCLTH-RXN|RHEA:45200 go.json http://purl.obolibrary.org/obo/GO_0102036 GO:0102035 biolink:MolecularActivity isobutyryl-CoA:FAD oxidoreductase activity Catalysis of the reaction: H+ + isobutyryl-CoA + FAD = methacrylyl-CoA + FADH2. EC:1.3.8.5|MetaCyc:MEPROPCOA-FAD-RXN go.json http://purl.obolibrary.org/obo/GO_0102035 GO:0102038 biolink:MolecularActivity 4-nitrobenzyl alcohol oxidase activity Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide. MetaCyc:R362-RXN go.json http://purl.obolibrary.org/obo/GO_0102038 GO:0102037 biolink:MolecularActivity 4-nitrotoluene monooxygenase activity Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O. MetaCyc:R361-RXN go.json http://purl.obolibrary.org/obo/GO_0102037 GO:0102039 biolink:MolecularActivity NADH-dependent peroxiredoxin activity Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+. EC:1.11.1.26|MetaCyc:R4-RXN|RHEA:62628 go.json alkylhydroperoxide reductase activity http://purl.obolibrary.org/obo/GO_0102039 GO:0102041 biolink:MolecularActivity 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid. EC:2.5.1.105|MetaCyc:RXN-10009|RHEA:35951 go.json http://purl.obolibrary.org/obo/GO_0102041 GO:0102040 biolink:MolecularActivity fumarate reductase (menaquinone) Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone. EC:1.3.5.1|MetaCyc:R601-RXN|RHEA:27834 go.json http://purl.obolibrary.org/obo/GO_0102040 GO:0102043 biolink:MolecularActivity isopentenyl phosphate kinase activity Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) = isopentenyl diphosphate(3-) + ADP(3-). EC:2.7.4.26|MetaCyc:RXN-10068|RHEA:33963 go.json http://purl.obolibrary.org/obo/GO_0102043 GO:0102042 biolink:MolecularActivity dehydroquinate synthase activity Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+. EC:1.4.1.24|MetaCyc:RXN-10032|RHEA:25956 go.json http://purl.obolibrary.org/obo/GO_0102042 GO:0102045 biolink:MolecularActivity 3-chlorobenzoate-3,4-oxygenase activity Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor. MetaCyc:RXN-10422 go.json http://purl.obolibrary.org/obo/GO_0102045 GO:0102044 biolink:MolecularActivity 3-chlorobenzoate-4,5-oxygenase activity Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor. MetaCyc:RXN-10421 go.json http://purl.obolibrary.org/obo/GO_0102044 GO:0102047 biolink:MolecularActivity indole-3-acetyl-glycine synthetase activity Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) = H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10429 go.json http://purl.obolibrary.org/obo/GO_0102047 GO:0102046 biolink:MolecularActivity 3,4-dichlorobenzoate-4,5-oxygenase activity Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor = 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor. MetaCyc:RXN-10427 go.json http://purl.obolibrary.org/obo/GO_0102046 GO:0102049 biolink:MolecularActivity indole-3-acetyl-methionine synthetase activity Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) = H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10431 go.json http://purl.obolibrary.org/obo/GO_0102049 GO:0102048 biolink:MolecularActivity indole-3-acetyl-isoleucine synthetase activity Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) = H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10430 go.json http://purl.obolibrary.org/obo/GO_0102048 GO:0102050 biolink:MolecularActivity indole-3-acetyl-tyrosine synthetase activity Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) = H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10432 go.json http://purl.obolibrary.org/obo/GO_0102050 GO:0102052 biolink:MolecularActivity indole-3-acetyl-proline synthetase activity Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) = H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10434 go.json http://purl.obolibrary.org/obo/GO_0102052 GO:0102051 biolink:MolecularActivity indole-3-acetyl-tryptophan synthetase activity Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) = H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10433 go.json http://purl.obolibrary.org/obo/GO_0102051 GO:0102054 biolink:MolecularActivity maleylpyruvate hydrolase activity Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O = H+ + maleate(2-) + pyruvate. EC:3.7.1.23|MetaCyc:RXN-10447|RHEA:47956 go.json http://purl.obolibrary.org/obo/GO_0102054 GO:0102053 biolink:MolecularActivity (-)-jasmonoyl-isoleucine synthetase activity Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) = H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid. MetaCyc:RXN-10435 go.json http://purl.obolibrary.org/obo/GO_0102053 GO:0102056 biolink:MolecularActivity 11-hydroxyjasmonate sulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate. EC:2.8.2.39|MetaCyc:RXN-10453|RHEA:52732 go.json http://purl.obolibrary.org/obo/GO_0102056 GO:0102055 biolink:MolecularActivity 12-hydroxyjasmonate sulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate. EC:2.8.2.39|MetaCyc:RXN-10451|RHEA:52728 go.json http://purl.obolibrary.org/obo/GO_0102055 GO:0102058 biolink:MolecularActivity jasmonoyl-leucine synthetase activity Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid = AMP(2-) + diphosphoric acid + a jasmonoyl-leucine. EC:6.3.2.52|MetaCyc:RXN-10459|RHEA:55772 go.json http://purl.obolibrary.org/obo/GO_0102058 GO:0102057 biolink:MolecularActivity jasmonoyl-valine synthetase activity Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid = AMP(2-) + diphosphoric acid + a jasmonoyl-valine. EC:6.3.2.52|MetaCyc:RXN-10457|RHEA:55772 go.json http://purl.obolibrary.org/obo/GO_0102057 GO:0102059 biolink:MolecularActivity 2-cis,6-cis-farnesyl pyrophosphate synthase activity Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate. EC:2.5.1.92|MetaCyc:RXN-10481|MetaCyc:RXN-11973|RHEA:27810 go.json neryl-diphosphate:isopentenyl-diphosphate cistransferase activity http://purl.obolibrary.org/obo/GO_0102059 GO:0102061 biolink:MolecularActivity endo-beta-bergamotene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphoric acid. EC:4.2.3.53|MetaCyc:RXN-10483|RHEA:30467 go.json (+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)|(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene|endo-beta-bergamontene synthase activity http://purl.obolibrary.org/obo/GO_0102061 GO:0102060 biolink:MolecularActivity endo-alpha-bergamotene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphoric acid. EC:4.2.3.54|MetaCyc:RXN-10482|RHEA:30471 go.json endo-alpha-bergamontene synthase activity http://purl.obolibrary.org/obo/GO_0102060 GO:0102063 biolink:MolecularActivity beta-curcumene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (-)-beta-curcumene. MetaCyc:RXN-10598 go.json http://purl.obolibrary.org/obo/GO_0102063 GO:0102062 biolink:MolecularActivity alpha-santalene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-alpha-santalene + diphosphoric acid. EC:4.2.3.50|MetaCyc:RXN-10567|RHEA:30463 go.json http://purl.obolibrary.org/obo/GO_0102062 GO:0102065 biolink:MolecularActivity patchoulene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + gamma-patchoulene. MetaCyc:RXN-10602 go.json http://purl.obolibrary.org/obo/GO_0102065 GO:0102064 biolink:MolecularActivity gamma-curcumene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = gamma-curcumene + diphosphoric acid. EC:4.2.3.94|MetaCyc:RXN-10599|RHEA:32031 go.json http://purl.obolibrary.org/obo/GO_0102064 GO:0102067 biolink:MolecularActivity geranylgeranyl diphosphate reductase activity Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+. EC:1.3.1.83|MetaCyc:RXN-10625|RHEA:26229 go.json http://purl.obolibrary.org/obo/GO_0102067 GO:0102066 biolink:MolecularActivity alpha-patchoulene synthase activityy Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene. MetaCyc:RXN-10603 go.json http://purl.obolibrary.org/obo/GO_0102066 GO:0102069 biolink:MolecularActivity zerumbone synthase activity Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD = zerumbone + NADH + H+. EC:1.1.1.326|MetaCyc:RXN-10629|RHEA:32327 go.json http://purl.obolibrary.org/obo/GO_0102069 GO:0102068 biolink:MolecularActivity alpha-humulene 10-hydroxylase activity Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ = 10-hydroxy-alpha-humulene + NADP + H2O. EC:1.14.14.113|MetaCyc:RXN-10628|RHEA:32491 go.json http://purl.obolibrary.org/obo/GO_0102068 GO:0102070 biolink:MolecularActivity 18-hydroxyoleate peroxygenase activity Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide = 9,10-epoxy-18-hydroxystearate + a lipid alcohol. EC:1.11.2.3|MetaCyc:RXN-1064 go.json http://purl.obolibrary.org/obo/GO_0102070 GO:0043050 biolink:BiologicalProcess nematode pharyngeal pumping The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes. go.json pumping behavior http://purl.obolibrary.org/obo/GO_0043050 GO:0008729 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008729 GO:0008728 biolink:MolecularActivity GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. EC:2.7.6.5|MetaCyc:GTPPYPHOSKIN-RXN|RHEA:22088 go.json (p)ppGpp synthetase I|(p)ppGpp synthetase II|ATP-GTP 3'-diphosphotransferase activity|ATP:GTP 3'-diphosphotransferase activity|GPSI|GPSII|GTP pyrophosphokinase activity|guanosine 3',5'-polyphosphate synthase activity|guanosine 5',3'-polyphosphate synthetase activity|guanosine pentaphosphate synthetase activity|ppGpp synthetase I activity|stringent factor activity http://purl.obolibrary.org/obo/GO_0008728 GO:0008727 biolink:MolecularActivity GDP-mannose mannosyl hydrolase activity Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+. MetaCyc:GDPMANMANHYDRO-RXN|RHEA:28102 go.json http://purl.obolibrary.org/obo/GO_0008727 GO:0043052 biolink:BiologicalProcess thermotaxis The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature. Wikipedia:Thermotaxis go.json taxis in response to temperature stimulus http://purl.obolibrary.org/obo/GO_0043052 GO:0008726 biolink:MolecularActivity alkanesulfonate monooxygenase activity Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. EC:1.14.14.5|MetaCyc:RXN0-280|RHEA:23064 go.json FMNH(2)-dependent aliphatic sulfonate monooxygenase activity|FMNH(2)-dependent alkanesulfonate monooxygenase activity|FMNH2-dependent aliphatic sulfonate monooxygenase activity|SsuD|alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity|alkanesulphonate monooxygenase activity|sulfate starvation-induced protein 6 activity http://purl.obolibrary.org/obo/GO_0008726 GO:0043051 biolink:BiologicalProcess regulation of nematode pharyngeal pumping Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes. go.json http://purl.obolibrary.org/obo/GO_0043051 GO:0008725 biolink:MolecularActivity DNA-3-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. EC:3.2.2.20|EC:3.2.2.21|MetaCyc:3.2.2.21-RXN|MetaCyc:RXN0-5189 go.json 3-methyladenine DNA glycosylase I|DNA glycosidase I activity|DNA-3-methyladenine glycosidase I activity|DNA-3-methyladenine glycosylase I activity|alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)|deoxyribonucleate 3-methyladenine glycosidase I http://purl.obolibrary.org/obo/GO_0008725 GO:0008724 biolink:MolecularActivity obsolete DNA topoisomerase IV activity OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo. go.json DNA topoisomerase IV activity True http://purl.obolibrary.org/obo/GO_0008724 GO:0008723 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008723 GO:0008722 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008722 GO:0008721 biolink:MolecularActivity D-serine ammonia-lyase activity Catalysis of the reaction: D-serine = pyruvate + NH3. EC:4.3.1.18|MetaCyc:DSERDEAM-RXN|RHEA:13977|Reactome:R-HSA-9014741|Reactome:R-HSA-9034539 go.json D-hydroxy amino acid dehydratase activity|D-hydroxyaminoacid dehydratase activity|D-serine ammonia-lyase (pyruvate-forming)|D-serine deaminase activity|D-serine dehydrase activity|D-serine dehydratase (deaminating) activity|D-serine dehydratase activity|D-serine dehydration activity|D-serine hydro-lyase (deaminating) activity|D-serine hydrolase activity http://purl.obolibrary.org/obo/GO_0008721 GO:0043058 biolink:BiologicalProcess regulation of backward locomotion Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism. go.json http://purl.obolibrary.org/obo/GO_0043058 GO:0008720 biolink:MolecularActivity D-lactate dehydrogenase activity Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate. EC:1.1.1.28|KEGG_REACTION:R00704|MetaCyc:DLACTDEHYDROGNAD-RXN|RHEA:16369 go.json D-lactic acid dehydrogenase activity|D-lactic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008720 GO:0043057 biolink:BiologicalProcess backward locomotion Posterior movement of an organism, e.g. following the direction of the tail of an animal. go.json http://purl.obolibrary.org/obo/GO_0043057 GO:0043059 biolink:BiologicalProcess regulation of forward locomotion Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism. go.json http://purl.obolibrary.org/obo/GO_0043059 GO:0043054 biolink:BiologicalProcess dauer exit Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development. go.json exit from nematode dormancy http://purl.obolibrary.org/obo/GO_0043054 GO:0043053 biolink:BiologicalProcess dauer entry Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development. go.json nematode entry into dormancy http://purl.obolibrary.org/obo/GO_0043053 GO:0043056 biolink:BiologicalProcess forward locomotion Anterior movement of an organism, following the direction of the head of the animal. go.json http://purl.obolibrary.org/obo/GO_0043056 GO:0043055 biolink:BiologicalProcess maintenance of dauer Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development. go.json maintenance of dormancy in the nematode http://purl.obolibrary.org/obo/GO_0043055 GO:0043061 biolink:BiologicalProcess meiotic metaphase II chromosome alignment A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during meiosis II chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. go.json http://purl.obolibrary.org/obo/GO_0043061 GO:0008739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008739 GO:0043060 biolink:BiologicalProcess meiotic metaphase I homologous chromosome alignment A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. go.json meiotic metaphase I chromosome alignment http://purl.obolibrary.org/obo/GO_0043060 GO:0008738 biolink:MolecularActivity L-fuculose-phosphate aldolase activity Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate. EC:4.1.2.17|KEGG_REACTION:R02262|MetaCyc:FUCPALDOL-RXN|RHEA:12933 go.json L-fuculose 1-phosphate aldolase activity|L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)|L-fuculose-1-phosphate lactaldehyde-lyase activity|fuculose aldolase activity http://purl.obolibrary.org/obo/GO_0008738 GO:0043063 biolink:BiologicalProcess intercellular bridge organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another. go.json intercellular bridge organisation|intercellular bridge organization and biogenesis http://purl.obolibrary.org/obo/GO_0043063 GO:0008737 biolink:MolecularActivity L-fuculokinase activity Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+. EC:2.7.1.51|KEGG_REACTION:R03241|MetaCyc:FUCULOKIN-RXN|RHEA:12376 go.json ATP:L-fuculose 1-phosphotransferase activity|L-fuculokinase (phosphorylating)|L-fuculose kinase activity http://purl.obolibrary.org/obo/GO_0008737 GO:0043062 biolink:BiologicalProcess extracellular structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. go.json extracellular structure organisation|extracellular structure organization and biogenesis http://purl.obolibrary.org/obo/GO_0043062 goslim_pir|prokaryote_subset GO:0008736 biolink:MolecularActivity L-fucose isomerase activity Catalysis of the reaction: L-fucose = L-fuculose. EC:5.3.1.25|MetaCyc:FUCISOM-RXN|RHEA:17233 go.json L-fucose aldose-ketose-isomerase activity|L-fucose ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0008736 GO:0008735 biolink:MolecularActivity L-carnitine CoA-transferase activity Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA. go.json L-carnitine dehydratase activity|L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]|L-carnitine hydro-lyase activity http://purl.obolibrary.org/obo/GO_0008735 GO:0008734 biolink:MolecularActivity L-aspartate oxidase activity Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide. EC:1.4.3.16|MetaCyc:L-ASPARTATE-OXID-RXN|MetaCyc:RXN-9772|RHEA:25876 go.json L-aspartate:oxygen oxidoreductase http://purl.obolibrary.org/obo/GO_0008734 GO:0008733 biolink:MolecularActivity L-arabinose isomerase activity Catalysis of the reaction: L-arabinose = L-ribulose. EC:5.3.1.4|KEGG_REACTION:R01761|MetaCyc:ARABISOM-RXN|RHEA:14821 go.json L-arabinose aldose-ketose-isomerase activity|L-arabinose ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0008733 GO:0008732 biolink:MolecularActivity L-allo-threonine aldolase activity Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde. EC:4.1.2.49|MetaCyc:LTAA-RXN|RHEA:26209 go.json L-allo-threonine acetaldehyde-lyase activity|LtaA http://purl.obolibrary.org/obo/GO_0008732 GO:0043069 biolink:BiologicalProcess negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. go.json down regulation of programmed cell death|down-regulation of programmed cell death|downregulation of programmed cell death|inhibition of programmed cell death|negative regulation of non-apoptotic programmed cell death http://purl.obolibrary.org/obo/GO_0043069 GO:0043068 biolink:BiologicalProcess positive regulation of programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. go.json activation of programmed cell death|positive regulation of non-apoptotic programmed cell death|stimulation of programmed cell death|up regulation of programmed cell death|up-regulation of programmed cell death|upregulation of programmed cell death http://purl.obolibrary.org/obo/GO_0043068 GO:0008731 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008731 GO:0008730 biolink:MolecularActivity L(+)-tartrate dehydratase activity Catalysis of the reaction: L-tartrate = H2O + oxaloacetate. EC:4.2.1.32|KEGG_REACTION:R00339|MetaCyc:LTARTDEHYDRA-RXN|RHEA:15413 go.json (R,R)-tartrate hydro-lyase (oxaloacetate-forming)|(R,R)-tartrate hydro-lyase activity|L-(+)-tartaric acid dehydratase activity|L-tartrate dehydratase activity|tartaric acid dehydrase activity|tartrate dehydratase activity http://purl.obolibrary.org/obo/GO_0008730 GO:0043065 biolink:BiologicalProcess positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. go.json activation of apoptosis|positive regulation of apoptosis|pro-apoptosis|stimulation of apoptosis|up regulation of apoptosis|up-regulation of apoptosis|upregulation of apoptosis http://purl.obolibrary.org/obo/GO_0043065 goslim_chembl GO:0043064 biolink:BiologicalProcess obsolete flagellum organization OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement. go.json flagellum organisation|flagellum organization|flagellum organization and biogenesis True http://purl.obolibrary.org/obo/GO_0043064 GO:0043067 biolink:BiologicalProcess regulation of programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. go.json regulation of non-apoptotic programmed cell death http://purl.obolibrary.org/obo/GO_0043067 GO:0043066 biolink:BiologicalProcess negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. go.json anti-apoptosis|apoptosis inhibitor activity|down regulation of apoptosis|down-regulation of apoptosis|downregulation of apoptosis|inhibition of apoptosis|negative regulation of apoptosis|pro-survival http://purl.obolibrary.org/obo/GO_0043066 GO:0043072 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043072 GO:0008707 biolink:MolecularActivity 4-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. EC:3.1.3.26|MetaCyc:RXN-7241|RHEA:20960 go.json 6-phytase (name based on 1L-numbering system and not 1D-numbering)|6-phytase activity|myo-inositol-hexakisphosphate 6-phosphohydrolase activity|phytase activity|phytate 6-phosphatase activity http://purl.obolibrary.org/obo/GO_0008707 GO:0008706 biolink:MolecularActivity 6-phospho-beta-glucosidase activity Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose. EC:3.2.1.86|MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN|RHEA:10772 go.json 6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity|phospho-beta-glucosidase A|phospho-beta-glucosidase activity|phosphocellobiase activity http://purl.obolibrary.org/obo/GO_0008706 GO:0043071 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043071 GO:0008705 biolink:MolecularActivity methionine synthase activity Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. EC:2.1.1.13|KEGG_REACTION:R00946|MetaCyc:HOMOCYSMETB12-RXN|RHEA:11172|Reactome:R-HSA-174374|Reactome:R-HSA-3149539 go.json 5-methyltetrahydrofolate--homocysteine S-methyltransferase activity|5-methyltetrahydrofolate--homocysteine transmethylase activity|5-methyltetrahydrofolate-homocysteine S-methyltransferase activity|5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity|B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity|B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity|MetH|N(5)-methyltetrahydrofolate methyltransferase activity|N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity|N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity|N-methyltetrahydrofolate:L-homocysteine methyltransferase activity|N5-methyltetrahydrofolate methyltransferase activity|N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity|N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity|cobalamin-dependent methionine synthase activity|methionine synthase (cobalamin-dependent) activity|methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity|tetrahydrofolate methyltransferase activity|tetrahydropteroylglutamate methyltransferase activity|tetrahydropteroylglutamic methyltransferase activity|vitamin B12 methyltransferase activity http://purl.obolibrary.org/obo/GO_0008705 GO:0043074 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043074 GO:0008704 biolink:MolecularActivity 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. EC:5.3.3.10|MetaCyc:5.3.3.10-RXN|RHEA:18813|UM-BBD_reactionID:r0366 go.json 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase|5-carboxymethyl-2-hydroxymuconate D-isomerase activity|5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity|5-carboxymethyl-2-hydroxymuconic acid isomerase activity|CHM isomerase activity|HHDD isomerase activity|hpaG-1|hpaG1 http://purl.obolibrary.org/obo/GO_0008704 GO:0043073 biolink:CellularComponent germ cell nucleus The nucleus of a germ cell, a reproductive cell in multicellular organisms. go.json germ-cell nucleus http://purl.obolibrary.org/obo/GO_0043073 GO:0008703 biolink:MolecularActivity 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH. EC:1.1.1.193|KEGG_REACTION:R03458|MetaCyc:RIBOFLAVINSYNREDUC-RXN|RHEA:17845 go.json 5-amino-6-(5'-phosphoribosylamino)uracil reductase activity|5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity|aminodioxyphosphoribosylaminopyrimidine reductase activity http://purl.obolibrary.org/obo/GO_0008703 GO:0008702 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008702 GO:0008701 biolink:MolecularActivity 4-hydroxy-2-oxovalerate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. EC:4.1.3.39|KEGG_REACTION:R00750|MetaCyc:MHPELY-RXN|RHEA:22624|UM-BBD_enzymeID:e0077 go.json 4-hydroxy-2-ketovalerate aldolase activity|4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity|4-hydroxy-2-oxopentanoate pyruvate-lyase activity|4-hydroxy-2-oxovalerate pyruvate-lyase activity|DmpG|HOA http://purl.obolibrary.org/obo/GO_0008701 GO:0043070 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043070 GO:0008700 biolink:MolecularActivity 4-hydroxy-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. EC:4.1.3.16|MetaCyc:4OH2OXOGLUTARALDOL-RXN|RHEA:18169|Reactome:R-HSA-6784423 go.json 2-keto-4-hydroxybutyrate aldolase activity|2-keto-4-hydroxyglutarate aldolase activity|2-keto-4-hydroxyglutaric aldolase activity|2-oxo-4-hydroxyglutarate aldolase activity|2-oxo-4-hydroxyglutaric aldolase activity|4-hydroxy-2-ketoglutarate aldolase activity|4-hydroxy-2-ketoglutaric aldolase activity|4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)|4-hydroxy-2-oxoglutarate glyoxylate-lyase activity|DL-4-hydroxy-2-ketoglutarate aldolase activity|KHG-aldolase activity|hydroxyketoglutarate aldolase activity|hydroxyketoglutaric aldolase activity http://purl.obolibrary.org/obo/GO_0008700 GO:0043079 biolink:CellularComponent antipodal cell nucleus The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents. go.json http://purl.obolibrary.org/obo/GO_0043079 GO:0043076 biolink:CellularComponent megasporocyte nucleus The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents. go.json megaspore mother cell nucleus http://purl.obolibrary.org/obo/GO_0043076 GO:0043075 biolink:CellularComponent obsolete sperm cell nucleus (sensu Magnoliophyta) OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents. go.json pollen germ cell nucleus|pollen germ-cell nucleus|sperm cell nucleus (sensu Magnoliophyta) True http://purl.obolibrary.org/obo/GO_0043075 GO:0043078 biolink:CellularComponent polar nucleus Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus. go.json http://purl.obolibrary.org/obo/GO_0043078 GO:0043077 biolink:BiologicalProcess initiation of acetate catabolic process The activation of the chemical reactions and pathways resulting in the breakdown of acetate. go.json initiation of acetate breakdown|initiation of acetate catabolism|initiation of acetate degradation http://purl.obolibrary.org/obo/GO_0043077 GO:0008709 biolink:MolecularActivity cholate 7-alpha-dehydrogenase activity Catalysis of the reaction: cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H+ + NADH. EC:1.1.1.159|KEGG_REACTION:R02792|MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN|RHEA:19409 go.json 7-alpha-hydroxysteroid dehydrogenase activity|7alpha-HSDH|7alpha-hydroxy steroid dehydrogenase activity|7alpha-hydroxysteroid dehydrogenase activity|7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008709 GO:0008708 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008708 GO:0043083 biolink:CellularComponent synaptic cleft The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. NIF_Subcellular:sao243541954 go.json http://purl.obolibrary.org/obo/GO_0043083 goslim_synapse GO:0008718 biolink:MolecularActivity D-amino-acid dehydrogenase activity Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. MetaCyc:RXN-11193|RHEA:18125 go.json D-amino-acid:(acceptor) oxidoreductase (deaminating)|D-amino-acid:acceptor oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0008718 GO:0043082 biolink:CellularComponent megagametophyte egg cell nucleus The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo. go.json http://purl.obolibrary.org/obo/GO_0043082 GO:0008717 biolink:MolecularActivity obsolete D-alanyl-D-alanine endopeptidase activity OBSOLETE. (Was not defined before being made obsolete). go.json D-alanyl-D-alanine endopeptidase activity|penicillin-binding protein 7|penicillin-binding protein 8 True http://purl.obolibrary.org/obo/GO_0008717 GO:0043085 biolink:BiologicalProcess positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme. go.json activation of enzyme activity|activation of metalloenzyme activity|positive regulation of enzyme activity|positive regulation of metalloenzyme activity|stimulation of enzyme activity|stimulation of metalloenzyme activity|up regulation of enzyme activity|up regulation of metalloenzyme activity|up-regulation of enzyme activity|up-regulation of metalloenzyme activity|upregulation of enzyme activity|upregulation of metalloenzyme activity http://purl.obolibrary.org/obo/GO_0043085 gocheck_do_not_annotate|goslim_chembl GO:0008716 biolink:MolecularActivity D-alanine-D-alanine ligase activity Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate. EC:6.3.2.4|KEGG_REACTION:R01150|MetaCyc:DALADALALIG-RXN|RHEA:11224 go.json D-Ala-D-Ala synthetase activity|D-alanine:D-alanine ligase (ADP-forming)|D-alanyl-D-alanine synthetase activity|D-alanylalanine synthetase activity|alanine:alanine ligase (ADP-forming) activity|alanylalanine synthetase activity http://purl.obolibrary.org/obo/GO_0008716 GO:0043084 biolink:BiologicalProcess penile erection The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. Wikipedia:Erection#Penile_erection go.json http://purl.obolibrary.org/obo/GO_0043084 GO:0008715 biolink:MolecularActivity CDP-diacylglycerol diphosphatase activity Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+. EC:3.6.1.26|KEGG_REACTION:R01797|MetaCyc:CDPDIGLYPYPHOSPHA-RXN|RHEA:15221 go.json CDP diacylglycerol hydrolase activity|CDP-diacylglycerol phosphatidylhydrolase activity|CDP-diacylglycerol pyrophosphatase activity|cytidine diphosphodiacylglycerol pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0008715 GO:0008714 biolink:MolecularActivity AMP nucleosidase activity Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. EC:3.2.2.4|KEGG_REACTION:R00182|MetaCyc:AMP-NUCLEOSID-RXN|RHEA:20129 go.json AMP phosphoribohydrolase activity|adenosine monophosphate nucleosidase activity|adenylate nucleosidase activity http://purl.obolibrary.org/obo/GO_0008714 GO:0008713 biolink:MolecularActivity ADP-heptose-lipopolysaccharide heptosyltransferase activity Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. MetaCyc:RXN0-5061|RHEA:28538 go.json ADP-heptose:LPS heptosyltransferase activity http://purl.obolibrary.org/obo/GO_0008713 GO:0008712 biolink:MolecularActivity ADP-glyceromanno-heptose 6-epimerase activity Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. EC:5.1.3.20|KEGG_REACTION:R05176|MetaCyc:5.1.3.20-RXN|RHEA:17577 go.json ADP-L-glycero-D-manno-heptose 6-epimerase activity|ADPglyceromanno-heptose 6-epimerase activity http://purl.obolibrary.org/obo/GO_0008712 GO:0043081 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043081 GO:0043080 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043080 GO:0008711 biolink:MolecularActivity obsolete ADP-L-glycero-D-manno-heptose synthase activity OBSOLETE. This term was not defined before being made obsolete. go.json ADP-L-glycero-D-manno-heptose synthase activity True http://purl.obolibrary.org/obo/GO_0008711 GO:0008710 biolink:MolecularActivity 8-amino-7-oxononanoate synthase activity Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA. EC:2.3.1.47|KEGG_REACTION:R03210|MetaCyc:7KAPSYN-RXN|RHEA:20712 go.json 6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)|7-KAP synthetase activity|7-keto-8-amino-pelargonic acid synthetase activity|7-keto-8-aminopelargonic acid synthetase activity|7-keto-8-aminopelargonic synthetase activity|8-amino-7-ketopelargonate synthase activity|8-amino-7-oxopelargonate synthase activity|AONS activity http://purl.obolibrary.org/obo/GO_0008710 GO:0043087 biolink:BiologicalProcess regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. go.json regulation of ARF GTPase activity|regulation of Cdc42 GTPase activity|regulation of Rab GTPase activity|regulation of Rac GTPase activity|regulation of Ral GTPase activity|regulation of Ran GTPase activity|regulation of Rap GTPase activity|regulation of Ras GTPase activity|regulation of Rho GTPase activity http://purl.obolibrary.org/obo/GO_0043087 gocheck_do_not_annotate GO:0043086 biolink:BiologicalProcess negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. go.json down regulation of enzyme activity|down regulation of metalloenzyme activity|down-regulation of enzyme activity|down-regulation of metalloenzyme activity|downregulation of enzyme activity|downregulation of metalloenzyme activity|inhibition of enzyme activity|inhibition of metalloenzyme activity|negative regulation of enzyme activity|negative regulation of metalloenzyme activity http://purl.obolibrary.org/obo/GO_0043086 gocheck_do_not_annotate GO:0043089 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043089 GO:0043088 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043088 GO:0008719 biolink:MolecularActivity dihydroneopterin triphosphate 2'-epimerase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate. EC:5.1.99.7|MetaCyc:H2NTPEPIM-RXN|RHEA:28346 go.json D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity http://purl.obolibrary.org/obo/GO_0008719 GO:0043094 biolink:BiologicalProcess cellular metabolic compound salvage Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. go.json http://purl.obolibrary.org/obo/GO_0043094 goslim_pir GO:0043093 biolink:BiologicalProcess FtsZ-dependent cytokinesis A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. Wikipedia:Binary_fission go.json cytokinesis by binary fission|prokaryote-type cytokinesis|prokaryotic fission http://purl.obolibrary.org/obo/GO_0043093 GO:0043096 biolink:BiologicalProcess purine nucleobase salvage Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis. go.json purine base salvage http://purl.obolibrary.org/obo/GO_0043096 GO:0043095 biolink:BiologicalProcess regulation of GTP cyclohydrolase I activity Any process that modulates the activity of the enzyme GTP cyclohydrolase I. go.json http://purl.obolibrary.org/obo/GO_0043095 gocheck_do_not_annotate GO:0043090 biolink:BiologicalProcess amino acid import The directed movement of amino acids into a cell or organelle. go.json amino acid uptake http://purl.obolibrary.org/obo/GO_0043090 GO:0043092 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043092 GO:0043091 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043091 GO:0043098 biolink:BiologicalProcess purine deoxyribonucleoside salvage Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0043098 GO:0043097 biolink:BiologicalProcess pyrimidine nucleoside salvage Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0043097 GO:0043099 biolink:BiologicalProcess pyrimidine deoxyribonucleoside salvage Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0043099 GO:0018250 biolink:BiologicalProcess peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG. RESID:AA0181 go.json peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine|peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine|peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine http://purl.obolibrary.org/obo/GO_0018250 gocheck_do_not_annotate GO:0033889 biolink:MolecularActivity N-sulfoglucosamine-3-sulfatase activity Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin. EC:3.1.6.15|MetaCyc:3.1.6.15-RXN go.json N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity|chondroitinsulfatase activity http://purl.obolibrary.org/obo/GO_0033889 GO:0033888 biolink:MolecularActivity chondro-6-sulfatase activity Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate. EC:3.1.6.10|KEGG_REACTION:R03518|MetaCyc:CHONDRO-6-SULFATASE-RXN|RHEA:10536 go.json 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0033888 GO:0033887 biolink:MolecularActivity chondro-4-sulfatase activity Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate. EC:3.1.6.9|KEGG_REACTION:R03517|MetaCyc:CHONDRO-4-SULFATASE-RXN|RHEA:11444 go.json 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0033887 GO:0043212 biolink:MolecularActivity carbohydrate-exporting ABC transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out). go.json carbohydrate-exporting ATPase activity http://purl.obolibrary.org/obo/GO_0043212 GO:0043211 biolink:MolecularActivity ABC-type carbohydrate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane. go.json ATP-dependent carbohydrate transmembrane transporter activity|ATPase-coupled carbohydrate transmembrane transporter activity|carbohydrate ABC transporter|carbohydrate-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0043211 GO:0043214 biolink:MolecularActivity ABC-type bacteriocin transporter activity Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. go.json ABC-type bacteriocin transmembrane transporter activity|ATPase-coupled bacteriocin transmembrane transporter activity|bacteriocin ABC transporter http://purl.obolibrary.org/obo/GO_0043214 GO:0043213 biolink:BiologicalProcess bacteriocin transport The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain. go.json http://purl.obolibrary.org/obo/GO_0043213 GO:0043210 biolink:MolecularActivity alkanesulfonate binding Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. go.json http://purl.obolibrary.org/obo/GO_0043210 GO:0043219 biolink:CellularComponent lateral loop Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode. NIF_Subcellular:sao1067215520|NIF_Subcellular:sao1354781919 go.json Schwann cell paranodal termination|oligodendrocyte paranodal termination|paranodal loop http://purl.obolibrary.org/obo/GO_0043219 GO:0018249 biolink:BiologicalProcess protein dehydration The removal of a water group from a protein amino acid. go.json protein amino acid dehydration http://purl.obolibrary.org/obo/GO_0018249 gocheck_do_not_annotate GO:0043216 biolink:MolecularActivity obsolete ATPase-coupled daunorubicin transmembrane transporter activity OBSOLETE. Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out). RHEA:33147 go.json ATP-dependent daunorubicin transmembrane transporter activity|daunorubicin ABC transporter|daunorubicin-transporting ATPase activity True http://purl.obolibrary.org/obo/GO_0043216 GO:0043215 biolink:BiologicalProcess daunorubicin transport The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0043215 GO:0018248 biolink:BiologicalProcess obsolete enzyme active site formation via peptidyl cysteine sulfation OBSOLETE. The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine. go.json enzyme active site formation via S-sulpho-L-cysteine True http://purl.obolibrary.org/obo/GO_0018248 GO:0043218 biolink:CellularComponent compact myelin The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. NIF_Subcellular:sao1123256993 go.json Schwann cell compact myelin|oligodendrocyte compact myelin http://purl.obolibrary.org/obo/GO_0043218 GO:0043217 biolink:BiologicalProcess myelin maintenance The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. go.json myelin sheath maintenance http://purl.obolibrary.org/obo/GO_0043217 GO:0033886 biolink:MolecularActivity cellulose-polysulfatase activity Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin. EC:3.1.6.7|MetaCyc:3.1.6.7-RXN go.json cellulose-sulfate sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0033886 GO:0018245 biolink:BiologicalProcess protein O-linked glycosylation via tyrosine The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen. RESID:AA0157 go.json protein amino acid O-linked glycosylation via tyrosine http://purl.obolibrary.org/obo/GO_0018245 GO:0033885 biolink:MolecularActivity 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate. EC:3.1.3.76|KEGG_REACTION:R07582|MetaCyc:3.1.3.76-RXN|RHEA:16537 go.json (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity|(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity|dihydroxy fatty acid phosphatase activity|hydroxy fatty acid phosphatase activity|hydroxy lipid phosphatase activity|lipid-phosphate phosphatase activity|sEH|soluble epoxide hydrolase activity http://purl.obolibrary.org/obo/GO_0033885 GO:0018244 biolink:BiologicalProcess protein N-linked glycosylation via tryptophan The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue. RESID:AA0156 go.json protein amino acid N-linked glycosylation via tryptophan http://purl.obolibrary.org/obo/GO_0018244 gocheck_do_not_annotate GO:0033884 biolink:MolecularActivity obsolete phosphoethanolamine/phosphocholine phosphatase activity OBSOLETE. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate. go.json 3X11A|PHOSPHO1|phosphoethanolamine phosphohydrolase activity|phosphoethanolamine/phosphocholine phosphatase activity True http://purl.obolibrary.org/obo/GO_0033884 GO:0018247 biolink:BiologicalProcess protein-phosphoribosyl dephospho-coenzyme A linkage The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position. RESID:AA0167 go.json http://purl.obolibrary.org/obo/GO_0018247 gocheck_do_not_annotate GO:0033883 biolink:MolecularActivity pyridoxal phosphatase activity Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. EC:3.1.3.74|MetaCyc:3.1.3.74-RXN|RHEA:20533 go.json PLP phosphatase activity|PNP phosphatase activity|pyridoxal-5'-phosphate phosphohydrolase activity|vitamin B6 (pyridoxine) phosphatase activity|vitamin B6-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0033883 GO:0018246 biolink:BiologicalProcess protein-coenzyme A linkage The formation of a linkage between a protein amino acid and coenzyme A. go.json http://purl.obolibrary.org/obo/GO_0018246 gocheck_do_not_annotate GO:0018241 biolink:BiologicalProcess protein O-linked glycosylation via hydroxylysine The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine. RESID:AA0153 go.json protein amino acid O-linked glycosylation via hydroxylysine http://purl.obolibrary.org/obo/GO_0018241 GO:0033882 biolink:MolecularActivity choloyl-CoA hydrolase activity Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA. EC:3.1.2.27|MetaCyc:3.1.2.27-RXN|RHEA:14541 go.json PTE-2|chenodeoxycholoyl-coenzyme A thioesterase activity|choloyl-coenzyme A thioesterase activity|peroxisomal acyl-CoA thioesterase 2 activity http://purl.obolibrary.org/obo/GO_0033882 GO:0033881 biolink:MolecularActivity bile-acid-CoA transferase activity Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA. EC:2.8.3.25|KEGG_REACTION:R07295|RHEA:49436 go.json bile-acid-CoA hydrolase activity|deoxycholoyl-CoA transferase activity http://purl.obolibrary.org/obo/GO_0033881 GO:0018240 biolink:BiologicalProcess protein S-linked glycosylation via cysteine The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine. RESID:AA0152 go.json protein amino acid S-linked glycosylation via cysteine http://purl.obolibrary.org/obo/GO_0018240 gocheck_do_not_annotate GO:0033880 biolink:MolecularActivity phenylacetyl-CoA hydrolase activity Catalysis of the reaction: H2O + phenylglyoxylyl-CoA = CoA + H+ + phenylglyoxylate. EC:3.1.2.25|KEGG_REACTION:R07294|MetaCyc:3.1.2.25-RXN|RHEA:15337 go.json phenylglyoxylyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0033880 GO:0018243 biolink:BiologicalProcess protein O-linked glycosylation via threonine The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine. RESID:AA0155 go.json protein amino acid O-linked glycosylation via threonine http://purl.obolibrary.org/obo/GO_0018243 GO:0018242 biolink:BiologicalProcess protein O-linked glycosylation via serine The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine. RESID:AA0154 go.json protein amino acid O-linked glycosylation via serine http://purl.obolibrary.org/obo/GO_0018242 GO:0018261 biolink:BiologicalProcess peptidyl-lysine guanylylation The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine. RESID:AA0228 go.json http://purl.obolibrary.org/obo/GO_0018261 gocheck_do_not_annotate GO:0018260 biolink:BiologicalProcess protein guanylylation The addition of phospho-guanosine to a protein amino acid. go.json protein amino acid guanylylation http://purl.obolibrary.org/obo/GO_0018260 gocheck_do_not_annotate GO:0033879 biolink:MolecularActivity acetylajmaline esterase activity Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate. EC:3.1.1.80|MetaCyc:RXN-8220|MetaCyc:RXN-8222 go.json 17-O-acetylajmaline O-acetylhydrolase activity|2beta(R)-17-O-acetylajmalan:acetylesterase activity|AAE|acetylajmalan esterase activity http://purl.obolibrary.org/obo/GO_0033879 GO:0033878 biolink:MolecularActivity hormone-sensitive lipase activity Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate. EC:3.1.1.79|MetaCyc:STEROL-ESTERASE-RXN|MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN go.json HSL|diacylglycerol acylhydrolase activity http://purl.obolibrary.org/obo/GO_0033878 GO:0033877 biolink:MolecularActivity succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate. EC:2.8.3.15|KEGG_REACTION:R05588|MetaCyc:RXN-864|RHEA:16469|UM-BBD_reactionID:r0329 go.json benzylsuccinate CoA-transferase activity|succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity|succinyl-CoA:benzylsuccinate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0033877 GO:0033876 biolink:MolecularActivity glycochenodeoxycholate sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H+. EC:2.8.2.34|KEGG_REACTION:R07289|MetaCyc:2.8.2.34-RXN|RHEA:17689 go.json 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity|BAST|bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity|bile acid:PAPS:sulfotransferase activity http://purl.obolibrary.org/obo/GO_0033876 GO:0043223 biolink:CellularComponent cytoplasmic SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). go.json cytoplasmic SCF complex|cytoplasmic Skp1/Cul1/F-box protein complex|cytoplasmic cullin complex http://purl.obolibrary.org/obo/GO_0043223 GO:0043222 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043222 GO:0043225 biolink:MolecularActivity ATPase-coupled inorganic anion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). Reactome:R-HSA-1454916|Reactome:R-HSA-5690340 go.json ATP-dependent anion transmembrane transporter activity|ATPase-coupled anion transmembrane transporter activity|anion ABC transporter|anion transmembrane-transporting ATPase activity|anion-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0043225 GO:0043224 biolink:CellularComponent nuclear SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). go.json nuclear SCF complex|nuclear Skp1/Cul1/F-box protein complex|nuclear cullin complex http://purl.obolibrary.org/obo/GO_0043224 GO:0043221 biolink:MolecularActivity SMC family protein binding Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization. go.json structural maintenance of chromosomes family protein binding http://purl.obolibrary.org/obo/GO_0043221 GO:0043220 biolink:CellularComponent Schmidt-Lanterman incisure Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. NIF_Subcellular:sao254777664 go.json Schmidt-Lanterman cleft http://purl.obolibrary.org/obo/GO_0043220 GO:0043227 biolink:CellularComponent membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. NIF_Subcellular:sao414196390 go.json membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0043227 GO:0018259 biolink:BiologicalProcess RNA-protein covalent cross-linking via peptidyl-serine The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine. RESID:AA0213 go.json http://purl.obolibrary.org/obo/GO_0018259 gocheck_do_not_annotate GO:0043226 biolink:CellularComponent organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. NIF_Subcellular:sao1539965131|Wikipedia:Organelle go.json http://purl.obolibrary.org/obo/GO_0043226 goslim_chembl|goslim_generic|goslim_pir|prokaryote_subset GO:0043229 biolink:CellularComponent intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0043229 goslim_pir GO:0043228 biolink:CellularComponent non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. NIF_Subcellular:sao1456184038 go.json biological condensate|non-membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0043228 goslim_mouse GO:0018256 biolink:BiologicalProcess protein formylation The addition of a formyl group to a protein amino acid. go.json protein amino acid formylation http://purl.obolibrary.org/obo/GO_0018256 gocheck_do_not_annotate GO:0033875 biolink:BiologicalProcess ribonucleoside bisphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json ribonucleoside bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0033875 GO:0018255 biolink:BiologicalProcess obsolete peptide cross-linking via S-glycyl-L-cysteine OBSOLETE. The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins. go.json True http://purl.obolibrary.org/obo/GO_0018255 GO:0033874 biolink:MolecularActivity scymnol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+. EC:2.8.2.32|KEGG_REACTION:R07798|MetaCyc:2.8.2.32-RXN|RHEA:15477 go.json http://purl.obolibrary.org/obo/GO_0033874 GO:0018258 biolink:BiologicalProcess protein O-linked glycosylation via hydroxyproline The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline. RESID:AA0212 go.json protein amino acid O-linked glycosylation via hydroxyproline http://purl.obolibrary.org/obo/GO_0018258 GO:0033873 biolink:MolecularActivity petromyzonol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H+. EC:2.8.2.31|KEGG_REACTION:R07797|MetaCyc:2.8.2.31-RXN|RHEA:16997 go.json 3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity|PZ-SULT http://purl.obolibrary.org/obo/GO_0033873 GO:0033872 biolink:MolecularActivity [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. EC:2.8.2.30|MetaCyc:2.8.2.30-RXN go.json 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity|3-OST-3|glucosaminyl 3-O-sulfotransferase 3 activity|glucosaminyl 3-O-sulfotransferase 3a, 3b activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity|heparin-glucosamine 3-sulfotransferase 3 activity|isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B) http://purl.obolibrary.org/obo/GO_0033872 GO:0018257 biolink:BiologicalProcess peptidyl-lysine formylation The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine. RESID:AA0211 go.json http://purl.obolibrary.org/obo/GO_0018257 gocheck_do_not_annotate GO:0033871 biolink:MolecularActivity [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S. EC:2.8.2.29|MetaCyc:2.8.2.29-RXN go.json 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity|3-OST-2|glucosaminyl 3-O-sulfotransferase 2 activity|glucosaminyl 3-O-sulfotransferase activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity|heparin-glucosamine 3-sulfotransferase 2 activity|isoform/isozyme 2 (3-OST-2, HS3ST2) http://purl.obolibrary.org/obo/GO_0033871 GO:0018252 biolink:BiologicalProcess obsolete peptide cross-linking via L-seryl-5-imidazolinone glycine OBSOLETE. The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. RESID:AA0184 go.json biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine True http://purl.obolibrary.org/obo/GO_0018252 GO:0033870 biolink:MolecularActivity thiol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate. EC:2.8.2.16|MetaCyc:THIOL-SULFOTRANSFERASE-RXN|RHEA:14637 go.json 3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity|PAPS sulfotransferase activity|adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity http://purl.obolibrary.org/obo/GO_0033870 GO:0018251 biolink:BiologicalProcess peptidyl-tyrosine dehydrogenation The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues. RESID:AA0183 go.json http://purl.obolibrary.org/obo/GO_0018251 gocheck_do_not_annotate GO:0018254 biolink:BiologicalProcess peptidyl-tyrosine adenylylation The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine. RESID:AA0203 go.json peptidyl-tyrosine adenylation http://purl.obolibrary.org/obo/GO_0018254 gocheck_do_not_annotate GO:0018253 biolink:BiologicalProcess peptide cross-linking via 5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde. RESID:AA0184|RESID:AA0187|RESID:AA0188 go.json biosynthesis of protein-protein cross-link via 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine http://purl.obolibrary.org/obo/GO_0018253 gocheck_do_not_annotate GO:0033869 biolink:BiologicalProcess nucleoside bisphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json nucleoside bisphosphate breakdown|nucleoside bisphosphate catabolism|nucleoside bisphosphate degradation http://purl.obolibrary.org/obo/GO_0033869 GO:0033868 biolink:MolecularActivity obsolete Goodpasture-antigen-binding protein kinase activity OBSOLETE. Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein. EC:2.7.11.9|MetaCyc:2.7.11.9-RXN go.json ATP:Goodpasture antigen-binding protein phosphotransferase activity|GPBP kinase activity|GPBPK|Goodpasture antigen-binding protein kinase activity|STK11 True http://purl.obolibrary.org/obo/GO_0033868 GO:0033867 biolink:MolecularActivity Fas-activated serine/threonine kinase activity Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein. EC:2.7.11.8|MetaCyc:2.7.11.8-RXN go.json ATP:Fas-activated serine/threonine protein phosphotransferase activity|FAST|FASTK|STK10 http://purl.obolibrary.org/obo/GO_0033867 GO:0033866 biolink:BiologicalProcess nucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json nucleoside bisphosphate anabolism|nucleoside bisphosphate biosynthesis|nucleoside bisphosphate formation|nucleoside bisphosphatehate synthesis http://purl.obolibrary.org/obo/GO_0033866 GO:0033865 biolink:BiologicalProcess nucleoside bisphosphate metabolic process The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. go.json nucleoside bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0033865 GO:0043234 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043234 GO:0043233 biolink:CellularComponent organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. go.json http://purl.obolibrary.org/obo/GO_0043233 goslim_mouse GO:0043236 biolink:MolecularActivity laminin binding Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. go.json laminin-2 binding|laminin-4 binding http://purl.obolibrary.org/obo/GO_0043236 GO:0043235 biolink:CellularComponent receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json http://purl.obolibrary.org/obo/GO_0043235 goslim_pir GO:0043230 biolink:CellularComponent extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. go.json http://purl.obolibrary.org/obo/GO_0043230 goslim_pir GO:0043232 biolink:CellularComponent intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. go.json intracellular non-membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0043232 goslim_pir GO:0043231 biolink:CellularComponent intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. go.json intracellular membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0043231 goslim_pir GO:0043238 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043238 GO:0018227 biolink:BiologicalProcess peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine. RESID:AA0103 go.json peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0018227 gocheck_do_not_annotate GO:0043237 biolink:MolecularActivity laminin-1 binding Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. go.json laminin-111 binding http://purl.obolibrary.org/obo/GO_0043237 GO:0018226 biolink:BiologicalProcess peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic. RESID:AA0102 go.json peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0018226 gocheck_do_not_annotate GO:0018229 biolink:BiologicalProcess obsolete peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine OBSOLETE. The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester. go.json peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine|peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine|peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine True http://purl.obolibrary.org/obo/GO_0018229 GO:0043239 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043239 GO:0018228 biolink:BiologicalProcess peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification. RESID:AA0104 go.json peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0018228 gocheck_do_not_annotate GO:0033864 biolink:BiologicalProcess positive regulation of NAD(P)H oxidase activity Any process that activates or increases the activity of the enzyme NAD(P)H oxidase. go.json activation of NAD(P)H oxidase activity|stimulation of NAD(P)H oxidase activity|up regulation of NAD(P)H oxidase activity|up-regulation of NAD(P)H oxidase activity|upregulation of NAD(P)H oxidase activity http://purl.obolibrary.org/obo/GO_0033864 gocheck_do_not_annotate GO:0018223 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018223 GO:0033863 biolink:MolecularActivity ribose 1,5-bisphosphate phosphokinase activity Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+. EC:2.7.4.23|KEGG_REACTION:R06836|MetaCyc:RXN0-1401|RHEA:20109 go.json ATP:ribose-1,5-bisphosphate phosphotransferase activity|PhnN|ribose 1,5-bisphosphokinase activity http://purl.obolibrary.org/obo/GO_0033863 GO:0018222 biolink:BiologicalProcess obsolete peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide. go.json peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine|peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine|peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine|peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine|peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine True http://purl.obolibrary.org/obo/GO_0018222 GO:0033862 biolink:MolecularActivity UMP kinase activity Catalysis of the reaction: ATP + UMP = ADP + UDP. EC:2.7.4.22|MetaCyc:2.7.4.22-RXN|RHEA:24400 go.json ATP:UMP phosphotransferase activity|PyrH|SmbA|UMP-kinase activity|UMPK|uridine monophosphate kinase activity http://purl.obolibrary.org/obo/GO_0033862 GO:0018225 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018225 GO:0033861 biolink:BiologicalProcess negative regulation of NAD(P)H oxidase activity Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase. go.json down regulation of NAD(P)H oxidase activity|down-regulation of NAD(P)H oxidase activity|downregulation of NAD(P)H oxidase activity|inhibition of NAD(P)H oxidase activity http://purl.obolibrary.org/obo/GO_0033861 gocheck_do_not_annotate GO:0018224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018224 GO:0033860 biolink:BiologicalProcess regulation of NAD(P)H oxidase activity Any process that modulates the activity of the enzyme NAD(P)H oxidase. go.json http://purl.obolibrary.org/obo/GO_0033860 gocheck_do_not_annotate GO:0018221 biolink:BiologicalProcess peptidyl-serine palmitoylation The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine. RESID:AA0080 go.json peptidyl-serine O-palmitoylation http://purl.obolibrary.org/obo/GO_0018221 gocheck_do_not_annotate GO:0018220 biolink:BiologicalProcess peptidyl-threonine palmitoylation The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine. RESID:AA0079 go.json peptidyl-threonine O-palmitoylation http://purl.obolibrary.org/obo/GO_0018220 gocheck_do_not_annotate GO:0033859 biolink:BiologicalProcess furaldehyde metabolic process The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass. go.json http://purl.obolibrary.org/obo/GO_0033859 GO:0033858 biolink:MolecularActivity N-acetylgalactosamine kinase activity Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate. EC:2.7.1.157|MetaCyc:2.7.1.157-RXN|RHEA:12617 go.json ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity|GALK2|GK2|GalNAc kinase activity|N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity http://purl.obolibrary.org/obo/GO_0033858 GO:0033857 biolink:MolecularActivity diphosphoinositol-pentakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate. EC:2.7.4.24|MetaCyc:2.7.4.24-RXN go.json 5-diphosphoinositol pentakisphosphate 3-kinase activity|PP-IP5 kinase activity|PP-InsP5 kinase activity|PPIP5K http://purl.obolibrary.org/obo/GO_0033857 GO:0033856 biolink:MolecularActivity pyridoxine 5'-phosphate synthase activity Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate. EC:2.6.99.2|KEGG_REACTION:R05838|MetaCyc:PDXJ-RXN|RHEA:15265 go.json 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity|PNP synthase activity|pyridoxine 5-phosphate phospho lyase activity http://purl.obolibrary.org/obo/GO_0033856 GO:0033855 biolink:MolecularActivity nicotianamine aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate. EC:2.6.1.80|KEGG_REACTION:R07277|MetaCyc:2.6.1.80-RXN|RHEA:22104 go.json NAAT|NAAT-I|NAAT-II|NAAT-III|nicotianamine transaminase activity|nicotianamine:2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0033855 GO:0033854 biolink:MolecularActivity glutamate-prephenate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate. EC:2.6.1.79|KEGG_REACTION:R07276|MetaCyc:PREPHENATE-TRANSAMINE-RXN|RHEA:22880 go.json L-arogenate:2-oxoglutarate aminotransferase activity|L-glutamate:prephenate aminotransferase activity|PAT|prephenate transaminase activity http://purl.obolibrary.org/obo/GO_0033854 GO:0043245 biolink:CellularComponent extraorganismal space The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms. go.json http://purl.obolibrary.org/obo/GO_0043245 GO:0043244 biolink:BiologicalProcess regulation of protein-containing complex disassembly Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. go.json regulation of protein complex disassembly http://purl.obolibrary.org/obo/GO_0043244 GO:0043247 biolink:BiologicalProcess telomere maintenance in response to DNA damage Any process that occur in response to the presence of critically short or damaged telomeres. go.json DNA damage response, telomere maintenance http://purl.obolibrary.org/obo/GO_0043247 GO:0043246 biolink:CellularComponent megasome Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex. go.json http://purl.obolibrary.org/obo/GO_0043246 GO:0043241 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043241 GO:0043240 biolink:CellularComponent Fanconi anaemia nuclear complex A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. go.json FA complex|FA core complex|FA nuclear complex|Fanconi anaemia complex http://purl.obolibrary.org/obo/GO_0043240 GO:0043243 biolink:BiologicalProcess positive regulation of protein-containing complex disassembly Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. go.json activation of protein complex disassembly|positive regulation of protein complex disassembly|stimulation of protein complex disassembly|up regulation of protein complex disassembly|up-regulation of protein complex disassembly|upregulation of protein complex disassembly http://purl.obolibrary.org/obo/GO_0043243 GO:0043242 biolink:BiologicalProcess negative regulation of protein-containing complex disassembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. go.json down regulation of protein complex disassembly|down-regulation of protein complex disassembly|downregulation of protein complex disassembly|inhibition of protein complex disassembly|negative regulation of protein complex disassembly http://purl.obolibrary.org/obo/GO_0043242 GO:0043249 biolink:BiologicalProcess erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. go.json RBC maturation|red blood cell maturation http://purl.obolibrary.org/obo/GO_0043249 GO:0018238 biolink:BiologicalProcess peptidyl-lysine carboxyethylation The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine. RESID:AA0115 go.json protein amino acid carboxyethylation http://purl.obolibrary.org/obo/GO_0018238 gocheck_do_not_annotate GO:0043248 biolink:BiologicalProcess proteasome assembly The aggregation, arrangement and bonding together of a mature, active proteasome complex. go.json 26S proteasome assembly|proteasome complex assembly|proteasome maturation http://purl.obolibrary.org/obo/GO_0043248 GO:0018237 biolink:MolecularActivity urease activator activity Increases the activity of urease by promoting the incorporation of nickel into the active site. go.json urease activase activity http://purl.obolibrary.org/obo/GO_0018237 GO:0018239 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018239 GO:0033853 biolink:MolecularActivity aspartate-prephenate aminotransferase activity Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate. EC:2.6.1.78|MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN|RHEA:20445 go.json L-arogenate:oxaloacetate aminotransferase activity|L-aspartate:prephenate aminotransferase activity|PAT|prephenate aspartate aminotransferase activity|prephenate transaminase activity http://purl.obolibrary.org/obo/GO_0033853 GO:0018234 biolink:BiologicalProcess peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase. RESID:AA0113 go.json http://purl.obolibrary.org/obo/GO_0018234 gocheck_do_not_annotate GO:0033852 biolink:MolecularActivity thyroid-hormone transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate. EC:2.6.1.26|KEGG_REACTION:R03952|MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN|RHEA:19133 go.json 3,5-dinitrotyrosine aminotransferase activity|3,5-dinitrotyrosine transaminase activity|L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity|thyroid hormone aminotransferase activity|thyroid-hormone aminotransferase activity http://purl.obolibrary.org/obo/GO_0033852 GO:0018233 biolink:BiologicalProcess peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link. RESID:AA0109 go.json http://purl.obolibrary.org/obo/GO_0018233 gocheck_do_not_annotate GO:0033851 biolink:MolecularActivity lavandulyl diphosphate synthase activity Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate. EC:2.5.1.69|KEGG_REACTION:R08950|MetaCyc:2.5.1.69-RXN|RHEA:21676 go.json FDS-5|dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity http://purl.obolibrary.org/obo/GO_0033851 GO:0018236 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018236 GO:0033850 biolink:MolecularActivity Z-farnesyl diphosphate synthase activity Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate. EC:2.5.1.68|KEGG_REACTION:R08528|MetaCyc:2.5.1.68-RXN|RHEA:23300 go.json (Z)-farnesyl diphosphate synthase activity|geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity http://purl.obolibrary.org/obo/GO_0033850 GO:0018235 biolink:BiologicalProcess peptidyl-lysine carboxylation The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine. RESID:AA0114 go.json http://purl.obolibrary.org/obo/GO_0018235 gocheck_do_not_annotate GO:0018230 biolink:BiologicalProcess peptidyl-L-cysteine S-palmitoylation The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine. RESID:AA0106 go.json peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|peptidyl-cysteine S-palmitoylation http://purl.obolibrary.org/obo/GO_0018230 gocheck_do_not_annotate GO:0018232 biolink:BiologicalProcess peptide cross-linking via S-(L-isoglutamyl)-L-cysteine The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link. RESID:AA0108 go.json http://purl.obolibrary.org/obo/GO_0018232 gocheck_do_not_annotate GO:0018231 biolink:BiologicalProcess peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids. RESID:AA0107 go.json peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine|peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine http://purl.obolibrary.org/obo/GO_0018231 gocheck_do_not_annotate GO:0033849 biolink:MolecularActivity chrysanthemyl diphosphate synthase activity Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate. EC:2.5.1.67|KEGG_REACTION:R08948|MetaCyc:2.5.1.67-RXN|RHEA:14009 go.json CPPase activity|dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity http://purl.obolibrary.org/obo/GO_0033849 GO:0043250 biolink:MolecularActivity sodium-dependent organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner. go.json http://purl.obolibrary.org/obo/GO_0043250 GO:0033848 biolink:MolecularActivity N2-(2-carboxyethyl)arginine synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H+ + phosphate. EC:2.5.1.66|KEGG_REACTION:R05465|MetaCyc:2.5.1.66-RXN|RHEA:10556 go.json CEA synthetase activity|CEAS|N2-(2-carboxyethyl)arginine synthetase activity|glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity|glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity http://purl.obolibrary.org/obo/GO_0033848 GO:0033847 biolink:MolecularActivity O-phosphoserine sulfhydrylase activity Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate. EC:2.5.1.65|MetaCyc:2.5.1.65-RXN|RHEA:10252 go.json O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity|O-phosphoserine(thiol)-lyase activity http://purl.obolibrary.org/obo/GO_0033847 GO:0033846 biolink:MolecularActivity adenosyl-fluoride synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine. EC:2.5.1.63|MetaCyc:2.5.1.63-RXN|RHEA:16661 go.json S-adenosyl-L-methionine:fluoride adenosyltransferase activity|fluorinase activity http://purl.obolibrary.org/obo/GO_0033846 GO:0008889 biolink:MolecularActivity glycerophosphodiester phosphodiesterase activity Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. EC:3.1.4.46|MetaCyc:GLYCPDIESTER-RXN|RHEA:12969|Reactome:R-HSA-1483107|Reactome:R-HSA-1483116 go.json IgD-binding protein D|gene hpd protein|glycerophosphodiester glycerophosphohydrolase activity|glycerophosphoryl diester phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0008889 GO:0033845 biolink:MolecularActivity hydroxymethylfurfural reductase (NADPH) activity Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+. go.json http://purl.obolibrary.org/obo/GO_0033845 GO:0008888 biolink:MolecularActivity glycerol dehydrogenase [NAD+] activity Catalysis of the reaction: glycerol + NAD+ = glycerone + H+ + NADH. EC:1.1.1.6|KEGG_REACTION:R01034|MetaCyc:GLYCDEH-RXN|RHEA:13769 go.json NAD-linked glycerol dehydrogenase activity|glycerol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008888 GO:0033844 biolink:MolecularActivity galactose-6-sulfurylase activity Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues. EC:2.5.1.5|MetaCyc:2.5.1.5-RXN go.json D-galactose-6-sulfate:alkyltransferase (cyclizing) activity|galactose 6-sulfatase activity|galactose-6-sulfatase activity|porphyran sulfatase activity http://purl.obolibrary.org/obo/GO_0033844 GO:0008887 biolink:MolecularActivity glycerate kinase activity Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. EC:2.7.1.31|KEGG_REACTION:R01514|MetaCyc:GLY3KIN-RXN|RHEA:23516|Reactome:R-HSA-6799495 go.json ATP:(R)-glycerate 3-phosphotransferase activity|ATP:D-glycerate 2-phosphotransferase activity|D-glycerate 3-kinase activity|D-glycerate kinase activity|D-glyceric acid kinase activity|GK|glycerate kinase (phosphorylating)|glycerate-3-kinase activity http://purl.obolibrary.org/obo/GO_0008887 GO:0033843 biolink:MolecularActivity xyloglucan 6-xylosyltransferase activity Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage. EC:2.4.2.39|MetaCyc:RXN-12415|MetaCyc:RXN-9461 go.json UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity|uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity|xyloglucan 6-alpha-D-xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0033843 GO:0043256 biolink:CellularComponent laminin complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. go.json http://purl.obolibrary.org/obo/GO_0043256 goslim_pir GO:0008886 biolink:MolecularActivity glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H2O + NADP+ = 3-phospho-D-glycerate + 2 H+ + NADPH. EC:1.2.1.9|KEGG_REACTION:R01058|MetaCyc:1.2.1.9-RXN|RHEA:14669 go.json D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity|NADP-glyceraldehyde phosphate dehydrogenase|NADP-glyceraldehyde-3-phosphate dehydrogenase activity|dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)|glyceraldehyde 3-phosphate dehydrogenase (NADP)|glyceraldehyde phosphate dehydrogenase (NADP)|glyceraldehyde-3-phosphate dehydrogenase (NADP)|glyceraldehyde-3-phosphate:NADP reductase activity|nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity|triosephosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008886 GO:0043255 biolink:BiologicalProcess regulation of carbohydrate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. go.json regulation of carbohydrate anabolism|regulation of carbohydrate biosynthesis|regulation of carbohydrate formation|regulation of carbohydrate synthesis http://purl.obolibrary.org/obo/GO_0043255 GO:0008885 biolink:MolecularActivity glutathionylspermidine synthase activity Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate. EC:6.3.1.8|MetaCyc:GSPSYN-RXN|RHEA:21272 go.json GSP synthetase activity|gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]|gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity|glutathione:spermidine ligase (ADP-forming) activity|glutathionylspermidine synthetase activity http://purl.obolibrary.org/obo/GO_0008885 GO:0008884 biolink:MolecularActivity glutathionylspermidine amidase activity Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine. EC:3.5.1.78|MetaCyc:GSPAMID-RXN|RHEA:17173 go.json GSP amidase activity|gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity|glutathionylspermidine amidohydrolase (spermidine-forming) activity http://purl.obolibrary.org/obo/GO_0008884 GO:0043258 biolink:CellularComponent laminin-9 complex A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains. go.json laminin-421 complex http://purl.obolibrary.org/obo/GO_0043258 GO:0008883 biolink:MolecularActivity glutamyl-tRNA reductase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH. EC:1.2.1.70|KEGG_REACTION:R04109|MetaCyc:GLUTRNAREDUCT-RXN|RHEA:12344 go.json L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming) http://purl.obolibrary.org/obo/GO_0008883 GO:0043257 biolink:CellularComponent laminin-8 complex A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains. go.json laminin-411 complex http://purl.obolibrary.org/obo/GO_0043257 GO:0008882 biolink:MolecularActivity [glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. EC:2.7.7.42|MetaCyc:GSADENYLATION-RXN|RHEA:18589 go.json ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity|ATP:[glutamate-ammonia-ligase] adenylyltransferase activity|ATP:glutamine synthetase adenylyltransferase activity|adenosine triphosphate:glutamine synthetase adenylyltransferase activity|glutamate-ammonia-ligase adenylyltransferase activity|glutamine-synthetase adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0008882 GO:0043252 biolink:BiologicalProcess sodium-independent organic anion transport The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0043252 GO:0043251 biolink:BiologicalProcess sodium-dependent organic anion transport The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0043251 GO:0008881 biolink:MolecularActivity glutamate racemase activity Catalysis of the reaction: L-glutamate = D-glutamate. EC:5.1.1.3|KEGG_REACTION:R00260|MetaCyc:GLUTRACE-RXN|RHEA:12813 go.json http://purl.obolibrary.org/obo/GO_0008881 GO:0008880 biolink:MolecularActivity glucuronate isomerase activity Catalysis of the reaction: D-glucuronate = D-fructuronate. EC:5.3.1.12|MetaCyc:GLUCUROISOM-RXN|RHEA:13049 go.json D-glucuronate aldose-ketose-isomerase activity|D-glucuronate isomerase activity|D-glucuronate ketol-isomerase activity|uronate isomerase activity|uronic acid isomerase activity|uronic isomerase activity http://purl.obolibrary.org/obo/GO_0008880 GO:0043254 biolink:BiologicalProcess regulation of protein-containing complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. go.json regulation of protein complex assembly http://purl.obolibrary.org/obo/GO_0043254 GO:0043253 biolink:CellularComponent chloroplast ribosome A ribosome contained within a chloroplast. go.json http://purl.obolibrary.org/obo/GO_0043253 GO:0018209 biolink:BiologicalProcess peptidyl-serine modification The modification of peptidyl-serine. go.json http://purl.obolibrary.org/obo/GO_0018209 gocheck_do_not_annotate GO:0018208 biolink:BiologicalProcess peptidyl-proline modification The modification of peptidyl-proline. go.json http://purl.obolibrary.org/obo/GO_0018208 gocheck_do_not_annotate GO:0018205 biolink:BiologicalProcess peptidyl-lysine modification The modification of peptidyl-lysine. go.json http://purl.obolibrary.org/obo/GO_0018205 gocheck_do_not_annotate GO:0043259 biolink:CellularComponent laminin-10 complex A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains. go.json laminin-511 complex http://purl.obolibrary.org/obo/GO_0043259 GO:0018204 biolink:BiologicalProcess peptidyl-leucine modification The modification of peptidyl-leucine. go.json http://purl.obolibrary.org/obo/GO_0018204 gocheck_do_not_annotate GO:0018207 biolink:BiologicalProcess peptidyl-phenylalanine modification The modification of peptidyl-phenylalanine. go.json http://purl.obolibrary.org/obo/GO_0018207 gocheck_do_not_annotate GO:0018206 biolink:BiologicalProcess peptidyl-methionine modification The modification of peptidyl-methionine. go.json http://purl.obolibrary.org/obo/GO_0018206 gocheck_do_not_annotate GO:0033842 biolink:MolecularActivity N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group. EC:2.4.1.244|MetaCyc:2.4.1.244-RXN|RHEA:20493 go.json UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity|beta1,4-N-acetylgalactosaminyltransferase III activity|beta1,4-N-acetylgalactosaminyltransferase IV activity|beta1,4-N-acetylgalactosaminyltransferase activity|beta4GalNAc-T3|beta4GalNAc-T4 http://purl.obolibrary.org/obo/GO_0033842 GO:0018201 biolink:BiologicalProcess peptidyl-glycine modification The modification of peptidyl-glycine. go.json http://purl.obolibrary.org/obo/GO_0018201 gocheck_do_not_annotate GO:0018200 biolink:BiologicalProcess peptidyl-glutamic acid modification The modification of peptidyl-glutamic acid. go.json http://purl.obolibrary.org/obo/GO_0018200 gocheck_do_not_annotate GO:0033841 biolink:MolecularActivity 6G-fructosyltransferase activity Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0). EC:2.4.1.243|MetaCyc:2.4.1.243-RXN go.json 1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity|6G-FFT|6G-FT|6G-fructotransferase activity|fructan:fructan 6G-fructosyltransferase activity http://purl.obolibrary.org/obo/GO_0033841 GO:0033840 biolink:MolecularActivity NDP-glucose-starch glucosyltransferase activity Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1. EC:2.4.1.242|MetaCyc:2.4.1.242-RXN|RHEA:15873 go.json GBSS|GBSSI|GBSSII|NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|NDPglucose-starch glucosyltransferase activity|granule-bound starch synthase I activity|granule-bound starch synthase II activity|granule-bound starch synthase activity|starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity|starch synthase II activity|waxy protein http://purl.obolibrary.org/obo/GO_0033840 GO:0018203 biolink:BiologicalProcess peptidyl-isoleucine modification The modification of peptidyl-isoleucine. go.json http://purl.obolibrary.org/obo/GO_0018203 gocheck_do_not_annotate GO:0018202 biolink:BiologicalProcess peptidyl-histidine modification The modification of peptidyl-histidine. go.json http://purl.obolibrary.org/obo/GO_0018202 gocheck_do_not_annotate GO:0033839 biolink:MolecularActivity flavonol-3-O-glycoside glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside. EC:2.4.1.240|MetaCyc:2.4.1.240-RXN|RHEA:23544 go.json UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033839 GO:0033838 biolink:MolecularActivity flavonol-3-O-glucoside glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside. EC:2.4.1.239|MetaCyc:2.4.1.239-RXN|RHEA:18893 go.json UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033838 GO:0043261 biolink:CellularComponent laminin-12 complex A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains. go.json laminin-213 complex http://purl.obolibrary.org/obo/GO_0043261 GO:0033837 biolink:MolecularActivity anthocyanin 3'-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside. EC:2.4.1.238|MetaCyc:RXN-8231|RHEA:35627 go.json 3'GT|UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity|UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033837 GO:0033836 biolink:MolecularActivity flavonol 7-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside. EC:2.4.1.237|MetaCyc:2.4.1.237-RXN|RHEA:23164 go.json UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity|UDP-glucose:flavonol 7-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033836 GO:0043260 biolink:CellularComponent laminin-11 complex A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains. go.json laminin-521 complex http://purl.obolibrary.org/obo/GO_0043260 GO:0033835 biolink:MolecularActivity flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]. EC:2.4.1.236|MetaCyc:RXN-5001|MetaCyc:RXN-5002|MetaCyc:RXN-5004|MetaCyc:RXN-7759|MetaCyc:RXN-9699|RHEA:15473 go.json 1->2 UDP-rhamnosyltransferase activity|UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity|UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity http://purl.obolibrary.org/obo/GO_0033835 GO:0033834 biolink:MolecularActivity kaempferol 3-O-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside. EC:2.4.1.234|MetaCyc:2.4.1.234-RXN|RHEA:15709 go.json F3GalTase activity|UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0033834 GO:0008899 biolink:MolecularActivity homoserine O-succinyltransferase activity Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA. EC:2.3.1.46|KEGG_REACTION:R01777|MetaCyc:HOMSUCTRAN-RXN|RHEA:22008 go.json homoserine O-transsuccinylase activity|homoserine succinyltransferase activity|succinyl-CoA:L-homoserine O-succinyltransferase activity http://purl.obolibrary.org/obo/GO_0008899 GO:0033833 biolink:MolecularActivity hydroxymethylfurfural reductase (NADH) activity Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+. MetaCyc:RXN-10738 go.json http://purl.obolibrary.org/obo/GO_0033833 GO:0008898 biolink:MolecularActivity S-adenosylmethionine-homocysteine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. EC:2.1.1.10|MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN|RHEA:21820 go.json L-homocysteine S-methyltransferase activity|S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity|S-adenosyl-L-methionine:L-homocysteine methyltransferase activity|S-adenosylmethionine homocysteine transmethylase activity|S-adenosylmethionine-homocysteine transmethylase activity|S-adenosylmethionine:homocysteine methyltransferase activity|adenosylmethionine transmethylase activity|adenosylmethionine:homocysteine methyltransferase activity|homocysteine methyltransferase activity|homocysteine transmethylase activity http://purl.obolibrary.org/obo/GO_0008898 GO:0033832 biolink:MolecularActivity alpha,alpha-trehalose phosphorylase (configuration-retaining) activity Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate. MetaCyc:RXN-4441|RHEA:16257 go.json alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity|trehalose phosphorylase activity http://purl.obolibrary.org/obo/GO_0033832 GO:0008897 biolink:MolecularActivity holo-[acyl-carrier-protein] synthase activity Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. EC:2.7.8.7|MetaCyc:HOLO-ACP-SYNTH-RXN|RHEA:12068|Reactome:R-HSA-199202 go.json 4'-phosphopantetheinyl transferase activity|4'-phosphopantetheinyltransferase activity|ACPS activity|AcpS|CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity|CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity|L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity|P-pant transferase activity|PPTase activity|acyl carrier protein holoprotein (holo-ACP) synthetase activity|acyl carrier protein synthase activity|acyl carrier protein synthetase activity|alpha-aminoadipate reductase phosphopantetheinyl transferase activity|alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity|alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity|coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity|holo-ACP synthase activity|holo-ACP synthetase activity|holo-[peptidyl-carrier protein] synthase activity|holo-acyl-carrier-protein synthase activity|holosynthase activity|phosphopantetheinyl transferase|phosphopantetheinyltransferase activity http://purl.obolibrary.org/obo/GO_0008897 GO:0043267 biolink:BiologicalProcess negative regulation of potassium ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of potassium ion transport|down-regulation of potassium ion transport|downregulation of potassium ion transport|inhibition of potassium ion transport|negative regulation of K+ transport|negative regulation of potassium ion conductance|negative regulation of potassium transport|regulation of K+ conductance|regulation of potassium conductance|transmembrane conductance regulator activity http://purl.obolibrary.org/obo/GO_0043267 GO:0043266 biolink:BiologicalProcess regulation of potassium ion transport Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of K+ conductance|regulation of K+ transport|regulation of potassium conductance|regulation of potassium ion conductance|regulation of potassium transport http://purl.obolibrary.org/obo/GO_0043266 GO:0008896 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008896 GO:0043269 biolink:BiologicalProcess regulation of monoatomic ion transport Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of ion transport http://purl.obolibrary.org/obo/GO_0043269 GO:0008895 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008895 GO:0008894 biolink:MolecularActivity guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. EC:3.6.1.40|MetaCyc:PPPGPPHYDRO-RXN|RHEA:13073 go.json guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity|guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity|guanosine pentaphosphatase activity|guanosine pentaphosphate phosphatase activity|guanosine pentaphosphate phosphohydrolase activity|guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity|guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity|pppGpp 5'-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008894 GO:0043268 biolink:BiologicalProcess positive regulation of potassium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of potassium ion transport|positive regulation of K+ conductance|positive regulation of K+ transport|positive regulation of potassium conductance|positive regulation of potassium ion conductance|positive regulation of potassium transport|stimulation of potassium ion transport|up regulation of potassium ion transport|up-regulation of potassium ion transport|upregulation of potassium ion transport http://purl.obolibrary.org/obo/GO_0043268 GO:0008893 biolink:MolecularActivity guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. EC:3.1.7.2|MetaCyc:PPGPPSYN-RXN|RHEA:14253 go.json (ppGpp)ase activity|PpGpp phosphohydrolase activity|PpGpp-3'-pyrophosphohydrolase activity|guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity|guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity|guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity|penta-phosphate guanosine-3'-diphosphohydrolase activity|penta-phosphate guanosine-3'-pyrophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008893 GO:0043263 biolink:CellularComponent cellulosome An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose. Wikipedia:Cellulosome go.json scaffoldin complex http://purl.obolibrary.org/obo/GO_0043263 GO:0043262 biolink:MolecularActivity ADP phosphatase activity Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+. MetaCyc:RXN-10862|RHEA:61436 go.json ADP diphosphatase activity|ADPase|ADPase activity|ATP diphosphohydrolase activity|ATP-diphosphatase activity|adenosine diphosphatase activity|adenosine-diphosphatase activity http://purl.obolibrary.org/obo/GO_0043262 GO:0008892 biolink:MolecularActivity guanine deaminase activity Catalysis of the reaction: guanine + H2O = xanthine + NH3. EC:3.5.4.3|MetaCyc:GUANINE-DEAMINASE-RXN|RHEA:14665|Reactome:R-HSA-74255 go.json GAH activity|guanase activity|guanine aminase activity|guanine aminohydrolase activity http://purl.obolibrary.org/obo/GO_0008892 GO:0043265 biolink:CellularComponent ectoplasm Granule free cytoplasm, lying immediately below the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0043265 GO:0008891 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008891 GO:0043264 biolink:CellularComponent extracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. go.json extracellular non-membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0043264 GO:0008890 biolink:MolecularActivity glycine C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA. EC:2.3.1.29|KEGG_REACTION:R00371|MetaCyc:AKBLIG-RXN|RHEA:20736 go.json glycine acetyltransferase activity http://purl.obolibrary.org/obo/GO_0008890 GO:0018219 biolink:BiologicalProcess peptidyl-cysteine S-acetylation The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine. RESID:AA0056 go.json http://purl.obolibrary.org/obo/GO_0018219 gocheck_do_not_annotate GO:0018216 biolink:BiologicalProcess peptidyl-arginine methylation The addition of a methyl group to an arginine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0018216 gocheck_do_not_annotate GO:0018215 biolink:BiologicalProcess protein phosphopantetheinylation The modification of a protein amino acid by phosphopantetheinylation. go.json protein amino acid phosphopantetheinylation http://purl.obolibrary.org/obo/GO_0018215 gocheck_do_not_annotate GO:0018218 biolink:BiologicalProcess peptidyl-cysteine phosphorylation The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine. RESID:AA0034 go.json http://purl.obolibrary.org/obo/GO_0018218 gocheck_do_not_annotate GO:0018217 biolink:BiologicalProcess peptidyl-aspartic acid phosphorylation The phosphorylation of peptidyl-aspartic acid. go.json http://purl.obolibrary.org/obo/GO_0018217 gocheck_do_not_annotate GO:0033831 biolink:MolecularActivity kojibiose phosphorylase activity Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose. EC:2.4.1.230|KEGG_REACTION:R07264|MetaCyc:2.4.1.230-RXN|RHEA:11176 go.json 2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033831 GO:0018212 biolink:BiologicalProcess peptidyl-tyrosine modification The modification of peptidyl-tyrosine. go.json http://purl.obolibrary.org/obo/GO_0018212 gocheck_do_not_annotate GO:0033830 biolink:MolecularActivity Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline. EC:2.4.1.229|RHEA:17841 go.json Skp1-HyPro GlcNAc-transferase activity|UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity|UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity|UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity|UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity http://purl.obolibrary.org/obo/GO_0033830 GO:0018211 biolink:BiologicalProcess peptidyl-tryptophan modification The chemical alteration of a tryptophan residue in a peptide. go.json http://purl.obolibrary.org/obo/GO_0018211 gocheck_do_not_annotate GO:0018214 biolink:BiologicalProcess protein carboxylation The addition of a carboxy group to a protein amino acid. go.json protein amino acid carboxylation http://purl.obolibrary.org/obo/GO_0018214 gocheck_do_not_annotate GO:0018213 biolink:BiologicalProcess peptidyl-valine modification The modification of peptidyl-valine. go.json http://purl.obolibrary.org/obo/GO_0018213 gocheck_do_not_annotate GO:0018210 biolink:BiologicalProcess peptidyl-threonine modification The modification of peptidyl-threonine. go.json http://purl.obolibrary.org/obo/GO_0018210 gocheck_do_not_annotate GO:0043270 biolink:BiologicalProcess positive regulation of monoatomic ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of ion transport|stimulation of ion transport|up regulation of ion transport|up-regulation of ion transport|upregulation of ion transport http://purl.obolibrary.org/obo/GO_0043270 GO:0033828 biolink:MolecularActivity glucosylglycerol-phosphate synthase activity Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H+. EC:2.4.1.213|KEGG_REACTION:R05328|MetaCyc:2.4.1.213-RXN|RHEA:12881 go.json ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity|ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity|GG-phosphate synthase activity|GGPS|glucosyl-glycerol-phosphate synthase activity http://purl.obolibrary.org/obo/GO_0033828 GO:0033827 biolink:MolecularActivity high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum. EC:2.4.1.197|MetaCyc:2.4.1.197-RXN go.json UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity|acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0033827 GO:0033826 biolink:MolecularActivity xyloglucan 4-glucosyltransferase activity Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage. EC:2.4.1.168|MetaCyc:RXN-12419 go.json UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity|UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity|uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity|xyloglucan 4beta-D-glucosyltransferase activity|xyloglucan glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033826 GO:0043272 biolink:BiologicalProcess ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance. go.json ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance|ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance|ethylene formation during jasmonic acid and ethylene-dependent systemic resistance|ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance http://purl.obolibrary.org/obo/GO_0043272 GO:0043271 biolink:BiologicalProcess negative regulation of monoatomic ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of ion transport|down-regulation of ion transport|downregulation of ion transport|inhibition of ion transport|negative regulation of ion transport http://purl.obolibrary.org/obo/GO_0043271 GO:0008869 biolink:MolecularActivity galactonate dehydratase activity Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O. EC:4.2.1.6|KEGG_REACTION:R03033|MetaCyc:GALACTONDEHYDRAT-RXN|RHEA:18649 go.json D-galactonate dehydrase activity|D-galactonate dehydratase activity|D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)|D-galactonate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0008869 GO:0033825 biolink:MolecularActivity oligosaccharide 4-alpha-D-glucosyltransferase activity Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides. EC:2.4.1.161|MetaCyc:2.4.1.161-RXN go.json 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity|amylase III activity http://purl.obolibrary.org/obo/GO_0033825 GO:0033824 biolink:MolecularActivity alternansucrase activity Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages. EC:2.4.1.140|MetaCyc:2.4.1.140-RXN go.json sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity|sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity|sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033824 GO:0008868 biolink:MolecularActivity galactitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+. EC:1.1.1.251|MetaCyc:1.1.1.251-RXN|RHEA:15137 go.json galactitol-1-phosphate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008868 GO:0033823 biolink:MolecularActivity procollagen glucosyltransferase activity Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen. EC:2.4.1.66|MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN|RHEA:12576|Reactome:R-HSA-1981157 go.json UDP-glucose-collagenglucosyltransferase activity|UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity|UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity|collagen glucosyltransferase activity|collagen hydroxylysyl glucosyltransferase activity|galactosylhydroxylysine glucosyltransferase activity|galactosylhydroxylysine-glucosyltransferase activity|galactosylhydroxylysyl glucosyltransferase activity|uridine diphosphoglucose-collagen glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033823 GO:0008867 biolink:MolecularActivity galactarate dehydratase activity Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O. EC:4.2.1.42|KEGG_REACTION:R05608|MetaCyc:GALACTARDEHYDRA-RXN|RHEA:16005 go.json D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)|D-galactarate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0008867 GO:0008866 biolink:MolecularActivity fructuronate reductase activity Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH. EC:1.1.1.57|KEGG_REACTION:R02454|MetaCyc:MANNONOXIDOREDUCT-RXN|RHEA:15729 go.json D-mannonate dehydrogenase activity|D-mannonate oxidoreductase activity|D-mannonate:NAD oxidoreductase activity|D-mannonate:NAD+ 5-oxidoreductase activity|mannonate oxidoreductase activity|mannonic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008866 GO:0033822 biolink:MolecularActivity glucosyl-DNA beta-glucosyltransferase activity Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA. EC:2.4.1.28|MetaCyc:2.4.1.28-RXN go.json T6-beta-glucosyl transferase activity|T6-glucosyl-HMC-beta-glucosyl transferase activity|UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity|UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity|uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033822 GO:0033821 biolink:MolecularActivity DNA beta-glucosyltransferase activity Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA. EC:2.4.1.27|MetaCyc:2.4.1.27-RXN go.json T4 phage beta-glucosyltransferase activity|T4-HMC-beta-glucosyl transferase activity|T4-beta-glucosyl transferase activity|UDP glucose-DNA beta-glucosyltransferase activity|UDP-glucose:DNA beta-D-glucosyltransferase activity|UDPglucose:DNA beta-D-glucosyltransferase activity|uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033821 GO:0008865 biolink:MolecularActivity fructokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. EC:2.7.1.4|MetaCyc:FRUCTOKINASE-RXN|RHEA:16125 go.json ATP:D-fructose 6-phosphotransferase activity|D-fructokinase activity|D-fructose(D-mannose)kinase activity|fructokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0008865 GO:0008864 biolink:MolecularActivity formyltetrahydrofolate deformylase activity Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+. EC:3.5.1.10|KEGG_REACTION:R00944|MetaCyc:FORMYLTHFDEFORMYL-RXN|RHEA:19833 go.json 10-formyltetrahydrofolate amidohydrolase activity|formyl-FH(4) hydrolase activity|formyltetrahydrofolate hydrolase activity http://purl.obolibrary.org/obo/GO_0008864 GO:0043278 biolink:BiologicalProcess response to morphine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. go.json http://purl.obolibrary.org/obo/GO_0043278 GO:0008863 biolink:MolecularActivity formate dehydrogenase (NAD+) activity Catalysis of the reaction: formate + NAD+ = CO2 + NADH. EC:1.17.1.9|KEGG_REACTION:R00519|MetaCyc:1.2.1.2-RXN|MetaCyc:FORMATEDEHYDROG-RXN|RHEA:15985|UM-BBD_reactionID:r0103 go.json NAD-dependent formate dehydrogenase|NAD-formate dehydrogenase|formate dehydrogenase (NAD)|formate hydrogenlyase|formate-NAD oxidoreductase|formic acid dehydrogenase|formic hydrogen-lyase http://purl.obolibrary.org/obo/GO_0008863 GO:0043277 biolink:BiologicalProcess apoptotic cell clearance The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. go.json apoptotic cell removal|efferocytosis|programmed cell clearance http://purl.obolibrary.org/obo/GO_0043277 GO:0008862 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008862 GO:0008861 biolink:MolecularActivity formate C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate. EC:2.3.1.54|MetaCyc:PYRUVFORMLY-RXN|RHEA:11844 go.json PFL|formate acetyltransferase activity http://purl.obolibrary.org/obo/GO_0008861 GO:0043279 biolink:BiologicalProcess response to alkaloid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. go.json http://purl.obolibrary.org/obo/GO_0043279 GO:0008860 biolink:MolecularActivity ferredoxin-NAD+ reductase activity Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+. EC:1.18.1.3|MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN|RHEA:16521 go.json NAD-ferredoxin reductase activity|NADH flavodoxin oxidoreductase activity|NADH-ferredoxin oxidoreductase activity|NADH-ferredoxin reductase activity|NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)|NADH-ferredoxinTOL reductase (component of toluene dioxygenase)|NADH2-ferredoxin oxidoreductase activity|ferredoxin-NAD reductase activity|ferredoxin-linked NAD reductase activity|ferredoxin-nicotinamide adenine dinucleotide reductase activity|ferredoxin:NAD+ oxidoreductase activity|reductase, reduced nicotinamide adenine dinucleotide-ferredoxin http://purl.obolibrary.org/obo/GO_0008860 GO:0043274 biolink:MolecularActivity phospholipase binding Binding to a phospholipase. go.json http://purl.obolibrary.org/obo/GO_0043274 GO:0043273 biolink:MolecularActivity CTPase activity Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction. RHEA:29387 go.json CTPase activity, coupled|cytidine triphosphatase activity|single-stranded DNA-dependent CTPase activity http://purl.obolibrary.org/obo/GO_0043273 GO:0043276 biolink:BiologicalProcess anoikis Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix. Wikipedia:Anoikis go.json detachment induced cell death|suspension induced apoptosis http://purl.obolibrary.org/obo/GO_0043276 GO:0043275 biolink:MolecularActivity obsolete glutamate carboxypeptidase II activity OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu. go.json N-acetylated alpha-linked acidic dipeptidase activity|N-acetylated-alpha-linked-amino dipeptidase activity|N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)|N-acetylated-gamma-linked-acidic dipeptidase activity|NAALA dipeptidase activity|NAALADase activity|PSM antigen|PSMA|acetylaspartylglutamate dipeptidase activity|folate hydrolase activity|folylpolyglutamate hydrolase activity|glutamate carboxypeptidase II activity|mGCP|membrane glutamate carboxypeptidase|microsomal gamma-glutamyl carboxypeptidase|prostate-specific membrane antigen|prostrate-specific membrane antigen|pteroylpoly-gamma-glutamate carboxypeptidase activity|pteroylpoly-gamma-glutamate hydrolase activity|pteroylpolygammaglutamyl hydrolase activity|pteroylpolyglutamate hydrolase activity|pteroylpolyglutamic acid hydrolase activity|rat NAAG peptidase True http://purl.obolibrary.org/obo/GO_0043275 GO:0033829 biolink:MolecularActivity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. EC:2.4.1.222|MetaCyc:2.4.1.222-RXN|Reactome:R-HSA-1912355|Reactome:R-HSA-5096538 go.json O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity|UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0033829 GO:0033820 biolink:MolecularActivity DNA alpha-glucosyltransferase activity Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA. EC:2.4.1.26|MetaCyc:2.4.1.26-RXN go.json T2-HMC-alpha-glucosyl transferase activity|T4-HMC-alpha-glucosyl transferase activity|T6-HMC-alpha-glucosyl transferase activity|UDP-glucose:DNA alpha-D-glucosyltransferase activity|UDPglucose-DNA alpha-glucosyltransferase activity|uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033820 GO:0033817 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033817 GO:0043281 biolink:BiologicalProcess regulation of cysteine-type endopeptidase activity involved in apoptotic process Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis. go.json regulation of caspase activation|regulation of caspase activity http://purl.obolibrary.org/obo/GO_0043281 gocheck_do_not_annotate GO:0033816 biolink:MolecularActivity diaminobutyrate acetyltransferase activity Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H+. EC:2.3.1.178|KEGG_REACTION:R06978|MetaCyc:R102-RXN|RHEA:16901 go.json 2,4-diaminobutanoate acetyltransferase activity|DAB acetyltransferase activity|DABA acetyltransferase activity|DABAcT|EctA|L-2,4-diaminobutanoate acetyltransferase activity|L-2,4-diaminobutyrate acetyltransferase activity|acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity|acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity|diaminobutyric acid acetyltransferase activity http://purl.obolibrary.org/obo/GO_0033816 GO:0043280 biolink:BiologicalProcess positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. go.json activation of caspase activity|positive regulation of caspase activity|stimulation of caspase activity|up regulation of caspase activity|up-regulation of caspase activity|upregulation of caspase activity http://purl.obolibrary.org/obo/GO_0043280 gocheck_do_not_annotate GO:0033815 biolink:MolecularActivity biphenyl synthase activity Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2. EC:2.3.1.177|MetaCyc:2.3.1.177-RXN|RHEA:22292 go.json BIS|malonyl-CoA:benzoyl-CoA malonyltransferase activity http://purl.obolibrary.org/obo/GO_0033815 GO:0043283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043283 GO:0033814 biolink:MolecularActivity propanoyl-CoA C-acyltransferase activity Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA. EC:2.3.1.176|MetaCyc:2.3.1.176-RXN|RHEA:16865 go.json 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity|PTE-2|SCP-X|SCPchi|peroxisomal thiolase 2 activity|sterol carrier protein-X|sterol carrier protein-chi http://purl.obolibrary.org/obo/GO_0033814 GO:0043282 biolink:BiologicalProcess chordate pharyngeal muscle development The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx. go.json http://purl.obolibrary.org/obo/GO_0043282 GO:0008879 biolink:MolecularActivity glucose-1-phosphate thymidylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. EC:2.7.7.24|KEGG_REACTION:R02328|MetaCyc:DTDPGLUCOSEPP-RXN|RHEA:15225 go.json TDP-glucose pyrophosphorylase activity|dTDP-glucose diphosphorylase activity|dTDP-glucose pyrophosphorylase activity|dTDP-glucose synthase activity|dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity|glucose 1-phosphate thymidylyltransferase activity|thymidine diphosphate glucose pyrophosphorylase activity|thymidine diphosphoglucose pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0008879 GO:0033813 biolink:MolecularActivity deacetylcephalosporin-C acetyltransferase activity Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA. EC:2.3.1.175|KEGG_REACTION:R03064|MetaCyc:2.3.1.175-RXN|RHEA:23860 go.json CPC acetylhydrolase activity|DAC acetyltransferase activity|DAC-AT|acetyl coenzyme A:DAC acetyltransferase activity|acetyl-CoA:DAC O-acetyltransferase activity|acetyl-CoA:DAC acetyltransferase activity|acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity|acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity|cefG|deacetylcephalosporin C acetyltransferase activity http://purl.obolibrary.org/obo/GO_0033813 GO:0008878 biolink:MolecularActivity glucose-1-phosphate adenylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate. EC:2.7.7.27|KEGG_REACTION:R00948|MetaCyc:GLUC1PADENYLTRANS-RXN|RHEA:12120 go.json ADGase activity|ADP glucose pyrophosphorylase activity|ADP-glucose diphosphorylase activity|ADP-glucose pyrophosphorylase activity|ADP-glucose synthase activity|ADP-glucose synthetase activity|ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity|ADPG pyrophosphorylase activity|ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity|ATP:alpha-glucose-1-phosphate adenylyl transferase activity|adenosine diphosphate glucose pyrophosphorylase activity|adenosine diphosphoglucose pyrophosphorylase activity|glucose 1-phosphate adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0008878 GO:0033812 biolink:MolecularActivity 3-oxoadipyl-CoA thiolase activity Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. EC:2.3.1.174|MetaCyc:RXN-3641|RHEA:19481 go.json succinyl-CoA:acetyl-CoA C-succinyltransferase activity http://purl.obolibrary.org/obo/GO_0033812 GO:0008877 biolink:MolecularActivity glucose-1-phosphatase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate. EC:3.1.3.10|KEGG_REACTION:R00304|MetaCyc:GLUCOSE-1-PHOSPHAT-RXN|RHEA:19933 go.json D-glucose-1-phosphate phosphohydrolase activity|alpha-D-glucose-1-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008877 GO:0033811 biolink:MolecularActivity flavonol-3-O-triglucoside O-coumaroyltransferase activity Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]. EC:2.3.1.173|MetaCyc:2.3.1.173-RXN|RHEA:22160 go.json 4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity http://purl.obolibrary.org/obo/GO_0033811 GO:0008876 biolink:MolecularActivity quinoprotein glucose dehydrogenase activity Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. EC:1.1.5.2|KEGG_REACTION:R00305|MetaCyc:RXN0-6373|RHEA:22152 go.json D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity|D-glucose:ubiquinone oxidoreductase activity|glucose dehydrogenase (PQQ-dependent) activity|glucose dehydrogenase (pyrroloquinoline-quinone) activity|quinoprotein D-glucose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008876 GO:0033810 biolink:MolecularActivity anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin. EC:2.3.1.172|MetaCyc:2.3.1.172-RXN|RHEA:21988 go.json Ss5MaT1|malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0033810 GO:0043289 biolink:BiologicalProcess apocarotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid. go.json apo carotenoid biosynthetic process|apocarotenoid anabolism|apocarotenoid biosynthesis|apocarotenoid formation|apocarotenoid synthesis http://purl.obolibrary.org/obo/GO_0043289 GO:0008875 biolink:MolecularActivity gluconate dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+. go.json http://purl.obolibrary.org/obo/GO_0008875 GO:0008874 biolink:MolecularActivity gluconate 5-dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+. EC:1.1.1.69|MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN go.json 5-keto-D-gluconate 5-reductase activity|5-keto-D-gluconate reductase|5-ketogluconate 5-reductase activity|5-ketogluconate reductase activity|D-gluconate:NAD(P)+ 5-oxidoreductase http://purl.obolibrary.org/obo/GO_0008874 GO:0043288 biolink:BiologicalProcess apocarotenoid metabolic process The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid. go.json apo carotenoid metabolic process|apocarotenoid metabolism http://purl.obolibrary.org/obo/GO_0043288 GO:0008873 biolink:MolecularActivity gluconate 2-dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+. EC:1.1.1.215|MetaCyc:1.1.1.215-RXN|RHEA:16653 go.json 2-keto-D-gluconate reductase activity|2-ketogluconate reductase activity http://purl.obolibrary.org/obo/GO_0008873 GO:0008872 biolink:MolecularActivity glucarate dehydratase activity Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. EC:4.2.1.40|MetaCyc:GLUCARDEHYDRA-RXN|RHEA:14573 go.json D-glucarate dehydratase activity|D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)|D-glucarate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0008872 GO:0008871 biolink:MolecularActivity aminoglycoside 2''-nucleotidyltransferase activity Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside. EC:2.7.7.46|MetaCyc:2.7.7.46-RXN go.json 2''-aminoglycoside nucleotidyltransferase activity|NTP:gentamicin 2''-nucleotidyltransferase activity|gentamicin 2''- adenylyltransferase activity|gentamicin 2''-nucleotidyltransferase activity|gentamycin 2''-nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0008871 GO:0043285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043285 GO:0008870 biolink:MolecularActivity galactoside O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside. EC:2.3.1.18|MetaCyc:GALACTOACETYLTRAN-RXN|RHEA:15713 go.json acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity|galactoside acetyltransferase activity|thiogalactoside acetyltransferase activity|thiogalactoside transacetylase activity http://purl.obolibrary.org/obo/GO_0008870 GO:0043284 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043284 GO:0033819 biolink:MolecularActivity lipoyl(octanoyl) transferase activity Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]. EC:2.3.1.181|MetaCyc:RXN0-947|RHEA:17665|Reactome:R-HSA-6793590 go.json lipoate/octanoate transferase activity|lipoyl (octanoyl)-acyl carrier protein:protein transferase activity|lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity|octanoyl transferase activity (acting on glycine-cleavage complex H protein)|octanoyl-acyl carrier protein-protein N-octanoyltransferase activity|octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity|octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity http://purl.obolibrary.org/obo/GO_0033819 GO:0043287 biolink:MolecularActivity poly(3-hydroxyalkanoate) binding Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. go.json PHA binding http://purl.obolibrary.org/obo/GO_0043287 GO:0033818 biolink:MolecularActivity beta-ketoacyl-acyl-carrier-protein synthase III activity Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2. EC:2.3.1.180|MetaCyc:2.3.1.180-RXN|RHEA:12080 go.json 3-ketoacyl-acyl carrier protein synthase III activity|3-oxoacyl:ACP synthase III activity|FabH|KAS III|KASIII|acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity|beta-ketoacyl (acyl carrier protein) synthase III activity|beta-ketoacyl-ACP synthase III activity|beta-ketoacyl-acyl carrier protein synthase III activity http://purl.obolibrary.org/obo/GO_0033818 GO:0043286 biolink:BiologicalProcess regulation of poly(3-hydroxyalkanoate) biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. go.json regulation of PHA|regulation of poly(3-hydroxyalkanoate) anabolism|regulation of poly(3-hydroxyalkanoate) biosynthesis|regulation of poly(3-hydroxyalkanoate) formation|regulation of poly(3-hydroxyalkanoate) synthesis http://purl.obolibrary.org/obo/GO_0043286 GO:0018292 biolink:BiologicalProcess molybdenum incorporation via L-cysteinyl molybdopterin The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin. RESID:AA0142 go.json http://purl.obolibrary.org/obo/GO_0018292 gocheck_do_not_annotate GO:0018291 biolink:BiologicalProcess molybdenum incorporation into iron-sulfur cluster The incorporation of molybdenum into an iron-sulfur cluster. go.json molybdenum incorporation into iron-sulphur cluster http://purl.obolibrary.org/obo/GO_0018291 gocheck_do_not_annotate GO:0018294 biolink:BiologicalProcess protein-FAD linkage via S-(8alpha-FAD)-L-cysteine The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine. RESID:AA0143 go.json http://purl.obolibrary.org/obo/GO_0018294 gocheck_do_not_annotate GO:0018293 biolink:BiologicalProcess protein-FAD linkage The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD). go.json http://purl.obolibrary.org/obo/GO_0018293 gocheck_do_not_annotate GO:0018290 biolink:BiologicalProcess iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase. RESID:AA0141 go.json iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide http://purl.obolibrary.org/obo/GO_0018290 gocheck_do_not_annotate GO:0018289 biolink:BiologicalProcess molybdenum incorporation into metallo-sulfur cluster The incorporation of molybdenum into a metallo-sulfur cluster. go.json molybdenum incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0018289 gocheck_do_not_annotate GO:0018288 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide. RESID:AA0140 go.json iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide http://purl.obolibrary.org/obo/GO_0018288 gocheck_do_not_annotate GO:0018285 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide. RESID:AA0137 go.json iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide http://purl.obolibrary.org/obo/GO_0018285 gocheck_do_not_annotate GO:0018284 biolink:BiologicalProcess iron incorporation into protein via tetrakis-L-cysteinyl iron The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein). RESID:AA0136 go.json http://purl.obolibrary.org/obo/GO_0018284 gocheck_do_not_annotate GO:0018287 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide. RESID:AA0139 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide http://purl.obolibrary.org/obo/GO_0018287 gocheck_do_not_annotate GO:0018286 biolink:BiologicalProcess obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form. go.json iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide|iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide True http://purl.obolibrary.org/obo/GO_0018286 GO:0018299 biolink:BiologicalProcess iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide. RESID:AA0225 go.json iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide http://purl.obolibrary.org/obo/GO_0018299 gocheck_do_not_annotate GO:0018296 biolink:BiologicalProcess protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine. RESID:AA0145 go.json http://purl.obolibrary.org/obo/GO_0018296 gocheck_do_not_annotate GO:0018295 biolink:BiologicalProcess protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine. RESID:AA0144 go.json http://purl.obolibrary.org/obo/GO_0018295 gocheck_do_not_annotate GO:0018298 biolink:BiologicalProcess obsolete protein-chromophore linkage OBSOLETE. The covalent or noncovalent attachment of a chromophore to a protein. go.json True http://purl.obolibrary.org/obo/GO_0018298 GO:0018297 biolink:BiologicalProcess protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine. RESID:AA0221 go.json http://purl.obolibrary.org/obo/GO_0018297 gocheck_do_not_annotate GO:0018270 biolink:BiologicalProcess GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0163 go.json GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0018270 GO:0018272 biolink:BiologicalProcess protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine. RESID:AA0119 go.json http://purl.obolibrary.org/obo/GO_0018272 gocheck_do_not_annotate GO:0018271 biolink:MolecularActivity biotin-protein ligase activity Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein. EC:6.3.4.-|MetaCyc:BIOTINLIG-RXN|Reactome:R-HSA-2993447|Reactome:R-HSA-2993799|Reactome:R-HSA-2993802|Reactome:R-HSA-2993814|Reactome:R-HSA-3323184|Reactome:R-HSA-4167511|Reactome:R-HSA-9035987|Reactome:R-HSA-9035988|Reactome:R-HSA-9035990 go.json biotin-apoprotein ligase activity http://purl.obolibrary.org/obo/GO_0018271 GO:0018267 biolink:BiologicalProcess GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0160 go.json GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0018267 gocheck_do_not_annotate GO:0018266 biolink:BiologicalProcess GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0159 go.json GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0018266 gocheck_do_not_annotate GO:0018269 biolink:BiologicalProcess GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0162 go.json GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0018269 gocheck_do_not_annotate GO:0018268 biolink:BiologicalProcess GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0161 go.json GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0018268 gocheck_do_not_annotate GO:0018263 biolink:BiologicalProcess obsolete isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine OBSOLETE. The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine. go.json True http://purl.obolibrary.org/obo/GO_0018263 GO:0018262 biolink:BiologicalProcess isopeptide cross-linking The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon. go.json http://purl.obolibrary.org/obo/GO_0018262 gocheck_do_not_annotate GO:0018265 biolink:BiologicalProcess GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0158 go.json GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine http://purl.obolibrary.org/obo/GO_0018265 gocheck_do_not_annotate GO:0018264 biolink:BiologicalProcess obsolete isopeptide cross-linking via N-(L-isoaspartyl)-glycine OBSOLETE. The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine. go.json True http://purl.obolibrary.org/obo/GO_0018264 GO:0018281 biolink:BiologicalProcess GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. RESID:AA0166 go.json GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine|GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine|GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine http://purl.obolibrary.org/obo/GO_0018281 gocheck_do_not_annotate GO:0018280 biolink:BiologicalProcess protein S-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine. go.json protein amino acid S-linked glycosylation http://purl.obolibrary.org/obo/GO_0018280 GO:0018283 biolink:BiologicalProcess iron incorporation into metallo-sulfur cluster The incorporation of iron into a metallo-sulfur cluster. go.json iron incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0018283 gocheck_do_not_annotate GO:0018282 biolink:BiologicalProcess metal incorporation into metallo-sulfur cluster The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide. go.json metal incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0018282 gocheck_do_not_annotate GO:0033899 biolink:MolecularActivity ribonuclease U2 activity Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates. EC:4.6.1.20|MetaCyc:3.1.27.3-RXN|MetaCyc:RXN-19928 go.json RNase U2 activity|pleospora RNase activity|purine specific endoribonuclease activity|purine-specific RNase activity|purine-specific ribonuclease activity|ribonuclease (purine) activity|trichoderma koningi RNase III activity http://purl.obolibrary.org/obo/GO_0033899 GO:0033898 biolink:MolecularActivity Bacillus subtilis ribonuclease activity Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides. EC:4.6.1.22|MetaCyc:RXN-19924 go.json proteus mirabilis RNase activity|ribonucleate nucleotido-2'-transferase (cyclizing) activity http://purl.obolibrary.org/obo/GO_0033898 GO:0043201 biolink:BiologicalProcess response to leucine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus. go.json http://purl.obolibrary.org/obo/GO_0043201 GO:0043200 biolink:BiologicalProcess response to amino acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. go.json response to amino acid stimulus http://purl.obolibrary.org/obo/GO_0043200 GO:0043203 biolink:CellularComponent axon hillock Portion of the neuronal cell soma from which the axon originates. NIF_Subcellular:sao627227260|Wikipedia:Axon_hillock go.json http://purl.obolibrary.org/obo/GO_0043203 GO:0043202 biolink:CellularComponent lysosomal lumen The volume enclosed within the lysosomal membrane. go.json http://purl.obolibrary.org/obo/GO_0043202 GO:0043209 biolink:CellularComponent myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. FMA:62983|NIF_Subcellular:sao593830697|Wikipedia:Myelin go.json Schwann cell myelin sheath|astrocyte sheath|oligodendrocyte myelin sheath http://purl.obolibrary.org/obo/GO_0043209 GO:0043208 biolink:MolecularActivity glycosphingolipid binding Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. go.json http://purl.obolibrary.org/obo/GO_0043208 GO:0043205 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043205 GO:0043204 biolink:CellularComponent perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus. go.json cell soma cytoplasm http://purl.obolibrary.org/obo/GO_0043204 GO:0043207 biolink:BiologicalProcess response to external biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. go.json http://purl.obolibrary.org/obo/GO_0043207 GO:0043206 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043206 GO:0033897 biolink:MolecularActivity ribonuclease T2 activity Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. EC:4.6.1.19|MetaCyc:3.1.27.5-RXN go.json Escherichia coli ribonuclease I' ribonuclease PP2 activity|Escherichia coli ribonuclease II activity|RNAase CL activity|RNase (non-base specific) activity|RNase II activity|RNase M activity|RNase Ms activity|RNase T2 activity|acid RNase activity|acid ribonuclease activity|base-non-specific ribonuclease activity|non-base specific ribonuclease activity|nonbase-specific RNase activity|nonspecific RNase activity|ribonnuclease (non-base specific) activity|ribonuclease (non-base specific) activity|ribonuclease II activity|ribonuclease M activity|ribonuclease N2 activity|ribonuclease PP3 activity|ribonuclease U4 activity|ribonucleate 3'-oligonucleotide hydrolase activity|ribonucleate nucleotido-2'-transferase (cyclizing) activity http://purl.obolibrary.org/obo/GO_0033897 GO:0018278 biolink:BiologicalProcess N-terminal peptidyl-threonine deamination The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid. RESID:AA0129 go.json http://purl.obolibrary.org/obo/GO_0018278 gocheck_do_not_annotate GO:0018277 biolink:BiologicalProcess protein deamination The removal of an amino group from a protein amino acid. go.json protein amino acid deamination http://purl.obolibrary.org/obo/GO_0018277 gocheck_do_not_annotate GO:0033896 biolink:MolecularActivity ribonuclease IX activity Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. EC:3.1.26.10|MetaCyc:3.1.26.10-RXN go.json poly(U)- and poly(C)-specific endoribonuclease activity http://purl.obolibrary.org/obo/GO_0033896 GO:0033895 biolink:MolecularActivity ribonuclease [poly-(U)-specific] activity Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. EC:3.1.26.9 go.json ribonuclease (uracil-specific) activity|uracil-specific RNase activity|uracil-specific endoribonuclease activity http://purl.obolibrary.org/obo/GO_0033895 GO:0033894 biolink:MolecularActivity ribonuclease P4 activity Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor. EC:3.1.26.7|MetaCyc:3.1.26.7-RXN go.json http://purl.obolibrary.org/obo/GO_0033894 GO:0018279 biolink:BiologicalProcess protein N-linked glycosylation via asparagine The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. go.json protein amino acid N-linked glycosylation via asparagine http://purl.obolibrary.org/obo/GO_0018279 GO:0033893 biolink:MolecularActivity ribonuclease IV activity Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. EC:3.1.26.6|MetaCyc:3.1.26.6-RXN go.json endoribonuclease IV activity http://purl.obolibrary.org/obo/GO_0033893 GO:0018274 biolink:BiologicalProcess peptide cross-linking via L-lysinoalanine The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link. RESID:AA0123 go.json http://purl.obolibrary.org/obo/GO_0018274 gocheck_do_not_annotate GO:0033892 biolink:MolecularActivity deoxyribonuclease (pyrimidine dimer) activity Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate. EC:3.1.25.1|MetaCyc:3.1.25.1-RXN go.json T4 endonuclease V activity|bacteriophage T4 endodeoxyribonuclease V activity|endodeoxyribonuclease (pyrimidine dimer) activity http://purl.obolibrary.org/obo/GO_0033892 GO:0018273 biolink:BiologicalProcess obsolete protein-chromophore linkage via peptidyl-N6-retinal-L-lysine OBSOLETE. The modification of peptidyl-lysine to form N6-retinal-L-lysine. RESID:AA0120 go.json True http://purl.obolibrary.org/obo/GO_0018273 GO:0018276 biolink:BiologicalProcess obsolete isopeptide cross-linking via N6-glycyl-L-lysine OBSOLETE. The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination. go.json True http://purl.obolibrary.org/obo/GO_0018276 GO:0033891 biolink:MolecularActivity CC-preferring endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC. EC:3.1.21.6|MetaCyc:3.1.21.6-RXN go.json 5'-CC-3'-preferring endodeoxyribonuclease activity|Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity|Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity|Streptomyces glaucescens exocytoplasmic endonuclease activity http://purl.obolibrary.org/obo/GO_0033891 GO:0018275 biolink:BiologicalProcess N-terminal peptidyl-cysteine acetylation The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine. RESID:AA0043 go.json peptidyl-cysteine N-acetylation http://purl.obolibrary.org/obo/GO_0018275 gocheck_do_not_annotate GO:0033890 biolink:MolecularActivity ribonuclease D activity Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides. EC:3.1.13.5|MetaCyc:3.1.13.5-RXN go.json RNase D activity http://purl.obolibrary.org/obo/GO_0033890 GO:0033806 biolink:MolecularActivity fluorothreonine transaldolase activity Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine. EC:2.2.1.8|RHEA:11748 go.json fluoroacetaldehyde:L-threonine aldehydetransferase activity http://purl.obolibrary.org/obo/GO_0033806 GO:0043171 biolink:BiologicalProcess peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. go.json peptide breakdown|peptide catabolism|peptide degradation http://purl.obolibrary.org/obo/GO_0043171 GO:0033805 biolink:MolecularActivity obsolete sarcosine/dimethylglycine N-methyltransferase activity OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine, and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine. go.json ApDMT|S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity|SDMT|sarcosine dimethylglycine N-methyltransferase activity|sarcosine dimethylglycine methyltransferase activity|sarcosine/dimethylglycine N-methyltransferase activity True http://purl.obolibrary.org/obo/GO_0033805 GO:0008849 biolink:MolecularActivity enterochelin esterase activity Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+. MetaCyc:RXN0-1661|RHEA:28018 go.json enterobactin esterase activity http://purl.obolibrary.org/obo/GO_0008849 GO:0043170 biolink:BiologicalProcess macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. go.json biopolymer metabolic process|macromolecule metabolism|multicellular organismal macromolecule metabolic process|organismal macromolecule metabolism http://purl.obolibrary.org/obo/GO_0043170 goslim_pir GO:0033804 biolink:MolecularActivity obsolete glycine/sarcosine N-methyltransferase activity OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine, and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine. go.json ApGSMT|GMT|GSMT|S-adenosyl-L-methionine:sarcosine N-methyltransferase activity|glycine sarcosine N-methyltransferase activity|glycine-sarcosine methyltransferase activity|glycine/sarcosine N-methyltransferase activity True http://purl.obolibrary.org/obo/GO_0033804 GO:0043173 biolink:BiologicalProcess nucleotide salvage Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. Wikipedia:Nucleotide_salvage go.json http://purl.obolibrary.org/obo/GO_0043173 GO:0008848 biolink:MolecularActivity obsolete enterobactin synthetase OBSOLETE. (Was not defined before being made obsolete). go.json enterobactin synthetase|enterochelin synthetase activity|nonribosomal peptide synthetase True http://purl.obolibrary.org/obo/GO_0008848 GO:0033803 biolink:MolecularActivity kaempferol 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H+ + kaempferide. EC:2.1.1.155|KEGG_REACTION:R06807|MetaCyc:2.1.1.155-RXN|RHEA:15105 go.json F 4'-OMT|S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity|S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0033803 GO:0043172 biolink:BiologicalProcess obsolete ferredoxin biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each. go.json ferredoxin anabolism|ferredoxin biosynthesis|ferredoxin formation|ferredoxin synthesis True http://purl.obolibrary.org/obo/GO_0043172 GO:0008847 biolink:MolecularActivity Enterobacter ribonuclease activity Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. EC:4.6.1.21|MetaCyc:3.1.27.6-RXN go.json Enterobacter RNase activity http://purl.obolibrary.org/obo/GO_0008847 GO:0008846 biolink:MolecularActivity obsolete endopeptidase La activity OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP. go.json ATP-dependent lon proteinase|ATP-dependent protease La activity|ATP-dependent serine proteinase activity|Escherichia coli proteinase La|Escherichia coli serine proteinase La|PIM1 protease activity|PIM1 proteinase activity|endopeptidase La activity|gene lon protease activity|gene lon proteins|lon proteinase|protease La|proteinase La|serine protease La True http://purl.obolibrary.org/obo/GO_0008846 GO:0033802 biolink:MolecularActivity isoliquiritigenin 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H+. EC:2.1.1.154|KEGG_REACTION:R07242|MetaCyc:RXN-3501|RHEA:21608 go.json CHMT|S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity|chalcone OMT http://purl.obolibrary.org/obo/GO_0033802 GO:0008845 biolink:MolecularActivity obsolete endonuclease VIII activity OBSOLETE. (Was not defined before being made obsolete). go.json endonuclease VIII activity True http://purl.obolibrary.org/obo/GO_0008845 GO:0033801 biolink:MolecularActivity vitexin 2''-O-rhamnoside 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside. EC:2.1.1.153|MetaCyc:RXN-4981|RHEA:11432 go.json S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0033801 GO:0033800 biolink:MolecularActivity isoflavone 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone. EC:2.1.1.150|MetaCyc:RXN-6241|RHEA:17933 go.json S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0033800 GO:0008844 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008844 GO:0008843 biolink:MolecularActivity endochitinase activity Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. go.json http://purl.obolibrary.org/obo/GO_0008843 GO:0008842 biolink:MolecularActivity diphosphate-purine nucleoside kinase activity Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide. EC:2.7.1.143|MetaCyc:2.7.1.143-RXN go.json diphosphate-dependent nucleoside kinase activity|diphosphate:purine nucleoside phosphotransferase activity|pyrophosphate-dependent nucleoside kinase activity|pyrophosphate-purine nucleoside kinase activity http://purl.obolibrary.org/obo/GO_0008842 GO:0043179 biolink:BiologicalProcess rhythmic excitation Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit. go.json http://purl.obolibrary.org/obo/GO_0043179 GO:0008841 biolink:MolecularActivity dihydrofolate synthase activity Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. EC:6.3.2.12|MetaCyc:DIHYDROFOLATESYNTH-RXN|RHEA:23584 go.json 7,8-dihydrofolate synthetase activity|7,8-dihydropteroate:L-glutamate ligase (ADP) activity|7,8-dihydropteroate:L-glutamate ligase (ADP-forming)|DHFS activity|FHFS activity|FHFS/FPGS activity|H(2)-folate synthetase activity|H2-folate synthetase activity|dihydrofolate synthetase activity|dihydrofolate synthetase-folylpolyglutamate synthetase activity|dihydropteroate:L-glutamate ligase (ADP-forming) activity|folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity http://purl.obolibrary.org/obo/GO_0008841 GO:0043178 biolink:MolecularActivity alcohol binding Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group. go.json http://purl.obolibrary.org/obo/GO_0043178 goslim_pir GO:0008840 biolink:MolecularActivity 4-hydroxy-tetrahydrodipicolinate synthase activity Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O. EC:4.3.3.7|KEGG_REACTION:R02292|MetaCyc:DIHYDRODIPICSYN-RXN|RHEA:34171 go.json DHDPS activity|L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)|L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]|dihydrodipicolinate synthase activity|dihydrodipicolinate synthetase activity|dihydrodipicolinic acid synthase activity http://purl.obolibrary.org/obo/GO_0008840 GO:0043175 biolink:MolecularActivity RNA polymerase core enzyme binding Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. go.json http://purl.obolibrary.org/obo/GO_0043175 GO:0033809 biolink:MolecularActivity anthocyanin 6''-O-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside). EC:2.3.1.171|MetaCyc:2.3.1.171-RXN|RHEA:16025 go.json 3MaT|Dv3MaT|malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity|malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0033809 GO:0043174 biolink:BiologicalProcess nucleoside salvage Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0043174 GO:0033808 biolink:MolecularActivity 6'-deoxychalcone synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O. EC:2.3.1.170|MetaCyc:RXN-3142|RHEA:10584 go.json malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity http://purl.obolibrary.org/obo/GO_0033808 GO:0043177 biolink:MolecularActivity organic acid binding Binding to an organic acid, any acidic compound containing carbon in covalent linkage. go.json http://purl.obolibrary.org/obo/GO_0043177 GO:0033807 biolink:MolecularActivity icosanoyl-CoA synthase activity Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+. EC:2.3.1.119|MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN go.json C18-CoA elongase activity|acyl-CoA elongase activity|stearoyl-CoA elongase activity|stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity http://purl.obolibrary.org/obo/GO_0033807 GO:0043176 biolink:MolecularActivity amine binding Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group. go.json http://purl.obolibrary.org/obo/GO_0043176 goslim_pir GO:0043182 biolink:BiologicalProcess vacuolar sequestering of sodium ion The process of transporting sodium ions into, and confining within, a vacuole. go.json sequestering of sodium ion (Na+) in vacuole|sequestration of sodium ion (Na+) in vacuole|sodium ion (Na+) retention in vacuole|sodium ion (Na+) storage in vacuole|vacuolar sequestering of sodium ion (Na+)|vacuolar sequestration of sodium ion (Na+)|vacuolar sodium ion (Na+) retention|vacuolar sodium ion (Na+) storage http://purl.obolibrary.org/obo/GO_0043182 GO:0043181 biolink:BiologicalProcess vacuolar sequestering The process of transporting a substance into, and confining within, a vacuole. go.json retention in vacuole|sequestering in vacuole|sequestration in vacuole|storage in vacuole|vacuolar retention|vacuolar sequestration|vacuolar storage http://purl.obolibrary.org/obo/GO_0043181 GO:0043184 biolink:MolecularActivity vascular endothelial growth factor receptor 2 binding Binding to a vascular endothelial growth factor receptor 2. go.json Flk-1 binding|KDR binding|VEGF receptor 2 binding|VEGFR 2 binding|kinase domain region binding http://purl.obolibrary.org/obo/GO_0043184 GO:0008859 biolink:MolecularActivity exoribonuclease II activity Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. EC:3.1.13.1|MetaCyc:3.1.13.1-RXN go.json 5'-exoribonuclease activity|BN ribonuclease activity|Escherichia coli exo-RNase II|RNase II|RNase II activity|ribonuclease II activity|ribonuclease Q http://purl.obolibrary.org/obo/GO_0008859 GO:0043183 biolink:MolecularActivity vascular endothelial growth factor receptor 1 binding Binding to a vascular endothelial growth factor receptor 1. go.json Flt-1 binding|VEGF receptor 1 binding|VEGFR 1 binding http://purl.obolibrary.org/obo/GO_0043183 GO:0008858 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008858 GO:0008857 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008857 GO:0008856 biolink:MolecularActivity obsolete exodeoxyribonuclease X activity OBSOLETE. Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes. EC:3.1.11.-|MetaCyc:3.1.22.5-RXN go.json Escherichia coli endodeoxyribonuclease X activity|Escherichia coli endodeoxyribonuclease activity|deoxyribonuclease X activity True http://purl.obolibrary.org/obo/GO_0008856 GO:0008855 biolink:MolecularActivity exodeoxyribonuclease VII activity Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. EC:3.1.11.6|MetaCyc:3.1.11.6-RXN go.json E. coli exonuclease VII|E. coli exonuclease VII activity|Escherichia coli exonuclease VII|endodeoxyribonuclease VII|exonuclease VII activity http://purl.obolibrary.org/obo/GO_0008855 GO:0043180 biolink:BiologicalProcess rhythmic inhibition Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit. go.json http://purl.obolibrary.org/obo/GO_0043180 GO:0008854 biolink:MolecularActivity exodeoxyribonuclease V activity Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. EC:3.1.11.5|MetaCyc:RXN0-2605 go.json E. coli exonuclease V|E. coli exonuclease V activity|Escherichia coli exonuclease V|RecBC deoxyribonuclease activity|exonuclease V activity|gene recBC DNase activity|gene recBC endoenzyme|gene recBCD enzymes http://purl.obolibrary.org/obo/GO_0008854 GO:0008853 biolink:MolecularActivity obsolete exodeoxyribonuclease III activity OBSOLETE. Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. go.json E. coli exonuclease III|E. coli exonuclease III activity|Escherichia coli exonuclease III|endoribonuclease III|exonuclease III activity True http://purl.obolibrary.org/obo/GO_0008853 GO:0008852 biolink:MolecularActivity obsolete exodeoxyribonuclease I activity OBSOLETE. Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. go.json E. coli exonuclease I|E. coli exonuclease I activity|Escherichia coli exonuclease I|exonuclease I activity True http://purl.obolibrary.org/obo/GO_0008852 GO:0043189 biolink:CellularComponent H4/H2A histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. go.json H4/H2A HAT complex http://purl.obolibrary.org/obo/GO_0043189 GO:0008851 biolink:MolecularActivity ethanolamine ammonia-lyase activity Catalysis of the reaction: ethanolamine = acetaldehyde + NH3. EC:4.3.1.7|MetaCyc:ETHAMLY-RXN|RHEA:15313 go.json ethanolamine ammonia-lyase (acetaldehyde-forming) activity|ethanolamine deaminase activity http://purl.obolibrary.org/obo/GO_0008851 GO:0008850 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008850 GO:0043186 biolink:CellularComponent P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. go.json germline granule|nuage|polar granule http://purl.obolibrary.org/obo/GO_0043186 GO:0043185 biolink:MolecularActivity vascular endothelial growth factor receptor 3 binding Binding to a vascular endothelial growth factor receptor 3. go.json VEGF receptor 3 binding|VEGFR 3 binding|fms-like-tyrosine kinase (Flt)-4 binding http://purl.obolibrary.org/obo/GO_0043185 GO:0043188 biolink:CellularComponent cell septum edging The cell wall material that surrounds the septum in fungal cells. go.json http://purl.obolibrary.org/obo/GO_0043188 GO:0043187 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043187 GO:0008828 biolink:MolecularActivity dATP diphosphatase activity Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. EC:3.6.1.56|MetaCyc:RXN0-384|RHEA:28334 go.json 2-hydroxy-(d)ATP pyrophosphatase activity|2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity|2-hydroxy-ATP pyrophosphatase activity|2-hydroxy-adenosine triphosphate pyrophosphatase activity|dATP pyrophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008828 GO:0043193 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043193 GO:0008827 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008827 GO:0043192 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043192 GO:0008826 biolink:MolecularActivity cysteine sulfinate desulfinase activity Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite. MetaCyc:RXN0-279|RHEA:28278 go.json cysteine sulphinate desulphinase activity http://purl.obolibrary.org/obo/GO_0008826 GO:0043195 biolink:CellularComponent terminal bouton Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. NIF_Subcellular:sao187426937 go.json bouton|presynaptic bouton|synaptic bouton|terminal button http://purl.obolibrary.org/obo/GO_0043195 GO:0008825 biolink:MolecularActivity cyclopropane-fatty-acyl-phospholipid synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. EC:2.1.1.79|MetaCyc:2.1.1.79-RXN|RHEA:11988 go.json CFA synthase activity|S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)|cyclopropane fatty acid synthase activity|cyclopropane fatty acid synthetase activity|cyclopropane synthase activity|cyclopropane synthetase activity|unsaturated-phospholipid methyltransferase activity http://purl.obolibrary.org/obo/GO_0008825 GO:0043194 biolink:CellularComponent axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. NIF_Subcellular:sao256000789 go.json initial segment http://purl.obolibrary.org/obo/GO_0043194 GO:0008824 biolink:MolecularActivity cyanate hydratase activity Catalysis of the reaction: cyanate + H2O = carbamate. EC:4.2.1.104|MetaCyc:R524-RXN|RHEA:11120|UM-BBD_reactionID:r0608 go.json carbamate hydro-lyase activity|cyanase activity|cyanate C-N-lyase activity|cyanate aminohydrolase activity|cyanate hydrolase activity|cyanate lyase activity http://purl.obolibrary.org/obo/GO_0008824 GO:0008823 biolink:MolecularActivity cupric reductase activity Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH. EC:1.16.1.-|MetaCyc:R170-RXN go.json http://purl.obolibrary.org/obo/GO_0008823 GO:0008822 biolink:MolecularActivity obsolete crotonobetaine/carnitine-CoA ligase activity OBSOLETE. (Was not defined before being made obsolete). go.json crotonobetaine/carnitine-CoA ligase activity True http://purl.obolibrary.org/obo/GO_0008822 GO:0043191 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043191 GO:0008821 biolink:MolecularActivity crossover junction DNA endonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). EC:3.1.21.10|MetaCyc:3.1.22.4-RXN go.json Hje endonuclease activity|Holliday junction endonuclease CCE1 activity|Holliday junction nuclease activity|Holliday junction resolvase activity|RusA endonuclease activity|RuvC endonuclease activity|SpCCe1 Holliday junction resolvase activity|SpCCe1 holliday junction resolvase|crossover junction endodeoxyribonuclease activity|crossover junction endoribonuclease activity|cruciform-cutting endonuclease activity|endo X3|endodeoxyribonuclease RUS activity|endonuclease RuvC activity|endonuclease VII activity|endonuclease X3 activity http://purl.obolibrary.org/obo/GO_0008821 GO:0043190 biolink:CellularComponent ATP-binding cassette (ABC) transporter complex A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. go.json ABC-type efflux permease complex|ABC-type efflux porter complex|ABC-type uptake permease complex|mating pheromone exporter http://purl.obolibrary.org/obo/GO_0043190 goslim_metagenomics|goslim_pir GO:0008820 biolink:MolecularActivity cobinamide phosphate guanylyltransferase activity Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate. EC:2.7.7.62|KEGG_REACTION:R05222|MetaCyc:COBINPGUANYLYLTRANS-RXN|RHEA:22712 go.json AdoCbi kinase/AdoCbi-phosphate guanylyltransferase|CobU|GTP:adenosylcobinamide-phosphate guanylyltransferase activity|GTP:cobinamide phosphate guanylyltransferase activity|adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase|adenosylcobinamide-phosphate guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0008820 GO:0043197 biolink:CellularComponent dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. NIF_Subcellular:sao1799103720|Wikipedia:Dendritic_spine go.json branched dendritic spine|dendrite spine|mushroom dendritic spine|sessile dendritic spine|stubby dendritic spine|thin dendritic spine http://purl.obolibrary.org/obo/GO_0043197 goslim_synapse GO:0043196 biolink:CellularComponent varicosity Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. go.json http://purl.obolibrary.org/obo/GO_0043196 GO:0043199 biolink:MolecularActivity sulfate binding Binding to sulfate, SO4(2-), a negatively charged small molecule. go.json http://purl.obolibrary.org/obo/GO_0043199 GO:0043198 biolink:CellularComponent dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. NIF_Subcellular:sao2034472720 go.json trunk http://purl.obolibrary.org/obo/GO_0043198 GO:0008829 biolink:MolecularActivity dCTP deaminase activity Catalysis of the reaction: dCTP + H2O = dUTP + NH3. EC:3.5.4.13|MetaCyc:DCTP-DEAM-RXN|RHEA:22680|Reactome:R-HSA-180632 go.json 5-methyl-dCTP deaminase activity|dCTP aminohydrolase activity|deoxycytidine triphosphate deaminase activity http://purl.obolibrary.org/obo/GO_0008829 GO:0008839 biolink:MolecularActivity 4-hydroxy-tetrahydrodipicolinate reductase Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. EC:1.17.1.8|MetaCyc:RXN-14014 go.json 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity|dihydrodipicolinate reductase activity|dihydrodipicolinic acid reductase activity http://purl.obolibrary.org/obo/GO_0008839 GO:0008838 biolink:MolecularActivity diaminopropionate ammonia-lyase activity Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3. EC:4.3.1.15|MetaCyc:4.3.1.15-RXN|RHEA:22084 go.json 2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)|2,3-diaminopropionate ammonia-lyase activity|alpha,beta-diaminopropionate ammonia-lyase activity|diaminopropionatase activity http://purl.obolibrary.org/obo/GO_0008838 GO:0008837 biolink:MolecularActivity diaminopimelate epimerase activity Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. EC:5.1.1.7|KEGG_REACTION:R02735|MetaCyc:DIAMINOPIMEPIM-RXN|RHEA:15393 go.json LL-2,6-diaminoheptanedioate 2-epimerase activity http://purl.obolibrary.org/obo/GO_0008837 GO:0008836 biolink:MolecularActivity diaminopimelate decarboxylase activity Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2. EC:4.1.1.20|KEGG_REACTION:R00451|MetaCyc:DIAMINOPIMDECARB-RXN|RHEA:15101 go.json DAP decarboxylase activity|DAP-decarboxylase activity|diaminopimelic acid decarboxylase activity|meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)|meso-2,6-diaminoheptanedioate carboxy-lyase activity|meso-diaminopimelate decarboxylase activity http://purl.obolibrary.org/obo/GO_0008836 GO:0008835 biolink:MolecularActivity diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4. EC:3.5.4.26|KEGG_REACTION:R03459|MetaCyc:RIBOFLAVINSYNDEAM-RXN|RHEA:21868 go.json 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity|2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity|2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity http://purl.obolibrary.org/obo/GO_0008835 GO:0008834 biolink:MolecularActivity di-trans,poly-cis-decaprenylcistransferase activity Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate. EC:2.5.1.31|MetaCyc:RXN-8999|RHEA:27551 go.json UPP synthetase activity|bactoprenyl-diphosphate synthase activity|di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity|di-trans,poly-cis-undecaprenyl-diphosphate synthase activity|undecaprenyl diphosphate synthase activity|undecaprenyl diphosphate synthetase activity|undecaprenyl pyrophosphate synthase activity|undecaprenyl pyrophosphate synthetase activity|undecaprenyl-diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0008834 GO:0008833 biolink:MolecularActivity deoxyribonuclease IV (phage-T4-induced) activity Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products. EC:3.1.21.2|MetaCyc:RXN-20410 go.json DNA-adenine-transferase activity|E. coli endonuclease IV|Escherichia coli endonuclease II|deoxriboendonuclease activity|deoxyribonuclease IV (phage T4-induced) activity|endodeoxyribonuclease IV (phage T(4)-induced) activity|endodeoxyribonuclease IV (phage T4-induced) activity|endonuclease II|endonuclease IV activity|redoxyendonuclease activity http://purl.obolibrary.org/obo/GO_0008833 GO:0008832 biolink:MolecularActivity dGTPase activity Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. EC:3.1.5.1|KEGG_REACTION:R01856|MetaCyc:DGTPTRIPHYDRO-RXN|RHEA:15193 go.json dGTP triphosphohydrolase activity|deoxy-GTPase activity|deoxyguanosine 5-triphosphate triphosphohydrolase activity|deoxyguanosine triphosphatase activity|deoxyguanosine triphosphate triphosphohydrolase activity|deoxyguanosinetriphosphate triphosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008832 GO:0008831 biolink:MolecularActivity dTDP-4-dehydrorhamnose reductase activity Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH. EC:1.1.1.133|KEGG_REACTION:R02777|MetaCyc:DTDPDEHYRHAMREDUCT-RXN|RHEA:21796 go.json TDP-4-keto-rhamnose reductase activity|dTDP-4-keto-L-rhamnose reductase activity|dTDP-4-ketorhamnose reductase activity|dTDP-6-deoxy-L-mannose dehydrogenase activity|dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity|reductase, thymidine diphospho-4-ketorhamnose|thymidine diphospho-4-ketorhamnose reductase activity http://purl.obolibrary.org/obo/GO_0008831 GO:0008830 biolink:MolecularActivity dTDP-4-dehydrorhamnose 3,5-epimerase activity Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. EC:5.1.3.13|KEGG_REACTION:R06514|MetaCyc:DTDPDEHYDRHAMEPIM-RXN|RHEA:16969 go.json TDP-4-keto-L-rhamnose-3,5-epimerase activity|TDP-4-ketorhamnose 3,5-epimerase activity|dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity|dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity|thymidine diphospho-4-ketorhamnose 3,5-epimerase activity http://purl.obolibrary.org/obo/GO_0008830 GO:0008806 biolink:MolecularActivity carboxymethylenebutenolidase activity Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate. EC:3.1.1.45|MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN|RHEA:12372|UM-BBD_enzymeID:e0066 go.json 4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity|carboxymethylene butenolide hydrolase activity|dienelactone hydrolase activity|maleylacetate enol-lactonase activity http://purl.obolibrary.org/obo/GO_0008806 GO:0008805 biolink:MolecularActivity carbon-monoxide oxygenase activity Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561. EC:1.2.5.3|MetaCyc:RXN-21452|RHEA:48880|UM-BBD_reactionID:r0650|Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) go.json carbon monoxide oxidase activity|carbon monoxide oxygenase (cytochrome b-561) activity|carbon monoxide oxygenase activity|carbon monoxide,water:cytochrome b-561 oxidoreductase activity|carbon monoxide:methylene blue oxidoreductase activity|carbon-monoxide dehydrogenase (cytochrome b-561)|cytochrome b561 http://purl.obolibrary.org/obo/GO_0008805 GO:0008804 biolink:MolecularActivity carbamate kinase activity Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate. EC:2.7.2.2|MetaCyc:CARBAMATE-KINASE-RXN|RHEA:10152 go.json ATP:carbamate phosphotransferase activity|CKase activity|carbamoyl phosphokinase activity|carbamyl phosphokinase activity http://purl.obolibrary.org/obo/GO_0008804 GO:0008803 biolink:MolecularActivity bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+. EC:3.6.1.41|KEGG_REACTION:R00125|MetaCyc:3.6.1.41-RXN|RHEA:24252 go.json 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity|Ap(4)A hydrolase activity|Ap4A hydrolase activity|P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity|adenosine tetraphosphate phosphodiesterase activity|bis(5'-adenosyl) tetraphosphatase activity|diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity|diadenosine 5',5'''-P1,P4-tetraphosphatase activity|diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity|diadenosine polyphosphate hydrolase activity|diadenosine tetraphosphatase (symmetrical)|diadenosine tetraphosphate hydrolase activity|diadenosinetetraphosphatase (symmetrical) activity|dinucleosidetetraphosphatase (symmetrical) activity|dinucleosidetetraphosphate (symmetrical)|symmetrical diadenosine tetraphosphate hydrolase activity http://purl.obolibrary.org/obo/GO_0008803 GO:0008802 biolink:MolecularActivity betaine-aldehyde dehydrogenase activity Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+. EC:1.2.1.8|MetaCyc:BADH-RXN|RHEA:15305|Reactome:R-HSA-6797955 go.json BADH activity|BetB|betaine aldehyde dehydrogenase activity|betaine aldehyde oxidase activity|betaine-aldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008802 GO:0008801 biolink:MolecularActivity beta-phosphoglucomutase activity Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate. EC:5.4.2.6|KEGG_REACTION:R02728|MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN|RHEA:20113 go.json beta-D-glucose 1,6-phosphomutase activity http://purl.obolibrary.org/obo/GO_0008801 GO:0008800 biolink:MolecularActivity beta-lactamase activity Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. EC:3.5.2.6|MetaCyc:BETA-LACTAMASE-RXN|RHEA:20401 go.json ampicillinase activity|beta-lactam hydrolase activity|beta-lactamase A, B, C|beta-lactamase AME I|beta-lactamase I-III|cephalosporin-beta-lactamase activity|exopenicillinase activity|neutrapen|penicillin amido-beta-lactamhydrolase activity|penicillin beta-lactamase activity|penicillinase I, II http://purl.obolibrary.org/obo/GO_0008800 GO:0008809 biolink:MolecularActivity carnitine racemase activity Catalysis of the reaction: D-carnitine = L-carnitine. MetaCyc:CARNRACE-RXN go.json http://purl.obolibrary.org/obo/GO_0008809 GO:0008808 biolink:MolecularActivity cardiolipin synthase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. MetaCyc:CARDIOLIPSYN-RXN|RHEA:31451 go.json cardiolipin synthase 2 activity|cardiolipin synthetase 2 activity|cardiolipin synthetase activity|diphosphatidylglycerol synthase activity http://purl.obolibrary.org/obo/GO_0008808 GO:0008807 biolink:MolecularActivity carboxyvinyl-carboxyphosphonate phosphorylmutase activity Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2. EC:2.7.8.23|MetaCyc:2.7.8.23-RXN|RHEA:14045 go.json 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)|CPEP phosphonomutase activity|carboxyphosphonoenolpyruvate phosphonomutase activity http://purl.obolibrary.org/obo/GO_0008807 GO:0008817 biolink:MolecularActivity corrinoid adenosyltransferase activity Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin. EC:2.5.1.17|KEGG_REACTION:R05218|MetaCyc:COBALADENOSYLTRANS-RXN|MetaCyc:R343-RXN|Reactome:R-HSA-3322125 go.json ATP:cob(I)alamin Co-beta-adenosyltransferase activity|ATP:cob(I)alamin cobeta-adenosyltransferase activity|ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity|ATP:corrinoid adenosyltransferase activity|aquacob(I)alamin adenosyltransferase activity|aquocob(I)alamin vitamin B12s adenosyltransferase activity|cob(I)alamin adenosyltransferase activity|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|cob(II)yrinic acid a,c-diamide reductase activity|cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity|vitamin B12s adenosyltransferase activity http://purl.obolibrary.org/obo/GO_0008817 GO:0008816 biolink:MolecularActivity citryl-CoA lyase activity Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. EC:4.1.3.34|MetaCyc:CITRYLY-RXN|RHEA:20812 go.json (3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)|(3S)-citryl-CoA oxaloacetate-lyase activity http://purl.obolibrary.org/obo/GO_0008816 GO:0008815 biolink:MolecularActivity citrate (pro-3S)-lyase activity Catalysis of the reaction: citrate = acetate + oxaloacetate. EC:4.1.3.6|KEGG_REACTION:R00362|MetaCyc:CITLY-RXN|RHEA:10760 go.json citrase activity|citratase activity|citrate aldolase activity|citrate lyase|citrate lyase activity|citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]|citrate oxaloacetate-lyase activity|citric aldolase activity|citridesmolase activity|citritase activity http://purl.obolibrary.org/obo/GO_0008815 GO:0008814 biolink:MolecularActivity citrate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. EC:2.8.3.10|MetaCyc:CITTRANS-RXN|RHEA:19405 go.json acetyl-CoA:citrate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0008814 GO:0008813 biolink:MolecularActivity chorismate lyase activity Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. EC:4.1.3.40|KEGG_REACTION:R01302|MetaCyc:CHORPYRLY-RXN|RHEA:16505 go.json 4-hydroxybenzoate synthetase activity|CL|CPL|UbiC|chorismate pyruvate lyase activity|chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity http://purl.obolibrary.org/obo/GO_0008813 GO:0008812 biolink:MolecularActivity choline dehydrogenase activity Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. EC:1.1.99.1|KEGG_REACTION:R01025|MetaCyc:CHD-RXN|RHEA:17433|Reactome:R-HSA-6797961 go.json choline oxidase activity|choline-cytochrome c reductase activity|choline:(acceptor) 1-oxidoreductase activity|choline:(acceptor) oxidoreductase activity|choline:acceptor 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008812 GO:0008811 biolink:MolecularActivity chloramphenicol O-acetyltransferase activity Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA. EC:2.3.1.28|KEGG_REACTION:R03065|MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN|RHEA:18421 go.json CAT I|CAT II|CAT III|acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity|chloramphenicol acetylase activity|chloramphenicol acetyltransferase activity|chloramphenicol transacetylase activity http://purl.obolibrary.org/obo/GO_0008811 GO:0008810 biolink:MolecularActivity cellulase activity Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. EC:3.2.1.4|MetaCyc:RXN-2043 go.json 1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity|9.5 cellulase activity|alkali cellulase activity|avicelase activity|beta-1,4-endoglucan hydrolase activity|beta-1,4-glucanase activity|carboxymethyl cellulase activity|celluase A|celludextrinase activity|cellulase A 3|cellulosin AP|endo-1,4-beta-D-glucanase activity|endo-1,4-beta-D-glucanohydrolase activity|endo-1,4-beta-glucanase activity|endoglucanase D|endoglucanase activity|pancellase SS http://purl.obolibrary.org/obo/GO_0008810 GO:0008819 biolink:MolecularActivity cobinamide kinase activity Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate. go.json http://purl.obolibrary.org/obo/GO_0008819 GO:0008818 biolink:MolecularActivity cobalamin 5'-phosphate synthase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. MetaCyc:COBALAMIN5PSYN-RXN|RHEA:23560 go.json http://purl.obolibrary.org/obo/GO_0008818 GO:0018371 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018371 GO:0018370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018370 GO:0043333 biolink:MolecularActivity 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. EC:2.1.1.201|MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN go.json 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity http://purl.obolibrary.org/obo/GO_0043333 GO:0043332 biolink:CellularComponent mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. go.json conjugation tube tip|shmoo tip http://purl.obolibrary.org/obo/GO_0043332 GO:0043335 biolink:BiologicalProcess protein unfolding The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. go.json http://purl.obolibrary.org/obo/GO_0043335 GO:0043334 biolink:MolecularActivity 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. go.json 2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity http://purl.obolibrary.org/obo/GO_0043334 GO:0043331 biolink:BiologicalProcess response to dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. go.json response to double-stranded RNA http://purl.obolibrary.org/obo/GO_0043331 GO:0043330 biolink:BiologicalProcess response to exogenous dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. go.json response to exogenous double-stranded RNA|response to viral dsRNA http://purl.obolibrary.org/obo/GO_0043330 GO:0043337 biolink:MolecularActivity cardiolipin synthase (CMP-forming) Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol. EC:2.7.8.41|MetaCyc:RXN-8141|RHEA:32931|Reactome:R-HSA-1483063 go.json CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity|cardiolipin synthase|cardiolipin synthetase http://purl.obolibrary.org/obo/GO_0043337 GO:0043336 biolink:MolecularActivity site-specific telomere resolvase activity Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases. go.json ResT|TelN http://purl.obolibrary.org/obo/GO_0043336 GO:0018369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018369 GO:0043339 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043339 GO:0043338 biolink:MolecularActivity CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol. EC:2.7.7.67|RHEA:25690 go.json CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase http://purl.obolibrary.org/obo/GO_0043338 GO:0018366 biolink:BiologicalProcess chiral amino acid racemization The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid. go.json http://purl.obolibrary.org/obo/GO_0018366 GO:0018365 biolink:MolecularActivity protein-serine epimerase activity Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine. EC:5.1.1.16|MetaCyc:5.1.1.16-RXN|RHEA:10660 go.json protein-serine racemase activity http://purl.obolibrary.org/obo/GO_0018365 GO:0018368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018368 GO:0018367 biolink:BiologicalProcess obsolete free L-amino acid racemization OBSOLETE. (Was not defined before being made obsolete). go.json free L-amino acid racemization True http://purl.obolibrary.org/obo/GO_0018367 GO:0018362 biolink:BiologicalProcess peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester. RESID:AA0279 go.json peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester http://purl.obolibrary.org/obo/GO_0018362 gocheck_do_not_annotate GO:0018361 biolink:BiologicalProcess peptidyl-glutamine 2-methylation The methylation of glutamine to form 2-methyl-L-glutamine. RESID:AA0273 go.json http://purl.obolibrary.org/obo/GO_0018361 gocheck_do_not_annotate GO:0018364 biolink:BiologicalProcess peptidyl-glutamine methylation The addition of a methyl group to a glutamine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0018364 gocheck_do_not_annotate GO:0018363 biolink:BiologicalProcess peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium. RESID:AA0280 go.json peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium|peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium http://purl.obolibrary.org/obo/GO_0018363 gocheck_do_not_annotate GO:0018380 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018380 GO:0018382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018382 GO:0018381 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018381 GO:0033999 biolink:MolecularActivity chondroitin B lyase activity Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate. EC:4.2.2.19|MetaCyc:4.2.2.19-RXN go.json ChnB|chonB|chondroitinase B activity|dermatan sulfate lyase activity http://purl.obolibrary.org/obo/GO_0033999 GO:0033998 biolink:MolecularActivity inulin fructotransferase (DFA-III-forming) activity Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. EC:4.2.2.18|MetaCyc:4.2.2.18-RXN go.json 2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity|inulase II activity|inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity|inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity|inulin fructotransferase (DFA-III-producing) activity|inulin fructotransferase (depolymerizing) activity|inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity|inulinase II activity http://purl.obolibrary.org/obo/GO_0033998 GO:0033997 biolink:MolecularActivity inulin fructotransferase (DFA-I-forming) activity Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. EC:4.2.2.17|MetaCyc:4.2.2.17-RXN go.json 2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity|inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity|inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity|inulin fructotransferase (DFA-I-producing) activity|inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity http://purl.obolibrary.org/obo/GO_0033997 GO:0043344 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043344 GO:0043343 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043343 GO:0043346 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043346 GO:0043345 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043345 GO:0043340 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043340 GO:0043342 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043342 GO:0043341 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043341 GO:0043348 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043348 GO:0043347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043347 GO:0043349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043349 GO:0033996 biolink:MolecularActivity levan fructotransferase (DFA-IV-forming) activity Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide. EC:4.2.2.16|MetaCyc:4.2.2.16-RXN go.json 2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity|2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity|levan fructotransferase activity http://purl.obolibrary.org/obo/GO_0033996 GO:0018377 biolink:BiologicalProcess protein myristoylation The covalent attachment of a myristoyl group to a protein. go.json protein amino acid myristoylation http://purl.obolibrary.org/obo/GO_0018377 gocheck_do_not_annotate GO:0033995 biolink:MolecularActivity anhydrosialidase activity Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate. EC:4.2.2.15|MetaCyc:4.2.2.15-RXN go.json anhydroneuraminidase activity|glycoconjugate sialyl-lyase (2,7-cyclizing) activity|sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity|sialidase L activity http://purl.obolibrary.org/obo/GO_0033995 GO:0018376 biolink:BiologicalProcess obsolete peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine OBSOLETE. The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). go.json True http://purl.obolibrary.org/obo/GO_0018376 GO:0033994 biolink:MolecularActivity glucuronan lyase activity Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides. EC:4.2.2.14|MetaCyc:4.2.2.14-RXN go.json (1,4)-beta-D-glucuronan lyase activity http://purl.obolibrary.org/obo/GO_0033994 GO:0018379 biolink:BiologicalProcess cytochrome c-heme linkage via heme-bis-L-cysteine The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine. RESID:AA0134 go.json cytochrome c-haem linkage via haem-bis-L-cysteine http://purl.obolibrary.org/obo/GO_0018379 gocheck_do_not_annotate GO:0033993 biolink:BiologicalProcess response to lipid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. go.json http://purl.obolibrary.org/obo/GO_0033993 GO:0018378 biolink:BiologicalProcess cytochrome c-heme linkage via heme-L-cysteine The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine. RESID:AA0135 go.json cytochrome c-haem linkage via haem-L-cysteine http://purl.obolibrary.org/obo/GO_0018378 gocheck_do_not_annotate GO:0033992 biolink:MolecularActivity 1,5-anhydro-D-fructose dehydratase activity Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O. EC:4.2.1.111|MetaCyc:4.2.1.111-RXN|RHEA:15725 go.json 1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity|1,5-anhydro-D-fructose 4-dehydratase activity|1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity|1,5-anhydro-D-fructose hydro-lyase activity|1,5-anhydro-D-fructose hydrolyase activity|AF dehydratase activity|AFDH http://purl.obolibrary.org/obo/GO_0033992 GO:0018373 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018373 GO:0033991 biolink:MolecularActivity aldos-2-ulose dehydratase activity Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one. EC:4.2.1.110|MetaCyc:RXN-14306|RHEA:12100 go.json 1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity|1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity|AUDH|pyranosone dehydratase activity http://purl.obolibrary.org/obo/GO_0033991 GO:0018372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018372 GO:0033990 biolink:MolecularActivity ectoine synthase activity Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H2O. EC:4.2.1.108|KEGG_REACTION:R06979|MetaCyc:R103-RXN|RHEA:17281 go.json 4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity|EctC|L-ectoine synthase activity|N-acetyldiaminobutanoate dehydratase activity|N-acetyldiaminobutyrate dehydratase activity|N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity http://purl.obolibrary.org/obo/GO_0033990 GO:0018375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018375 GO:0018374 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018374 GO:0033989 biolink:MolecularActivity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. EC:4.2.1.107|MetaCyc:4.2.1.107-RXN|RHEA:18933|Reactome:R-HSA-192331|Reactome:R-HSA-193535 go.json (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity|(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity|46 kDa hydratase 2 activity|D-3-hydroxyacyl-CoA dehydratase activity http://purl.obolibrary.org/obo/GO_0033989 GO:0033988 biolink:MolecularActivity bile-acid 7alpha-dehydratase activity Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O. EC:4.2.1.106|KEGG_REACTION:R07318|MetaCyc:BA7DEHYDRA-RXN|RHEA:10436 go.json 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity|7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity|BA7 alpha dehydratase activity http://purl.obolibrary.org/obo/GO_0033988 GO:0033987 biolink:MolecularActivity 2-hydroxyisoflavanone dehydratase activity Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O. EC:4.2.1.105|MetaCyc:RXN-3284|RHEA:16445 go.json 2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity|2,7,4'-trihydroxyisoflavanone hydro-lyase activity http://purl.obolibrary.org/obo/GO_0033987 GO:0033986 biolink:BiologicalProcess response to methanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus. go.json http://purl.obolibrary.org/obo/GO_0033986 GO:0043355 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043355 GO:0043354 biolink:BiologicalProcess enucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. go.json enucleate RBC maturation|enucleate red blood cell maturation http://purl.obolibrary.org/obo/GO_0043354 GO:0043357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043357 GO:0043356 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043356 GO:0043351 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043351 GO:0043350 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043350 GO:0043353 biolink:BiologicalProcess enucleate erythrocyte differentiation The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. go.json enucleate RBC differentiation|enucleate red blood cell differentiation http://purl.obolibrary.org/obo/GO_0043353 GO:0043352 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043352 GO:0043359 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043359 GO:0018348 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018348 GO:0043358 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043358 GO:0018347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018347 GO:0018349 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018349 GO:0018344 biolink:BiologicalProcess protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein. go.json C-terminal protein geranylgeranylation|protein amino acid geranylgeranylation http://purl.obolibrary.org/obo/GO_0018344 gocheck_do_not_annotate GO:0033985 biolink:CellularComponent acidocalcisome lumen The volume enclosed by the membranes of an acidocalcisome. go.json http://purl.obolibrary.org/obo/GO_0033985 GO:0033984 biolink:MolecularActivity indole-3-glycerol-phosphate lyase activity Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. EC:4.1.2.8|KEGG_REACTION:R02340|MetaCyc:RXN0-2381|RHEA:14081 go.json (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity|(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity|BX1|IGL|TSA|indole glycerol phosphate hydrolase activity|indole synthase activity|indole-3-glycerol phosphate lyase activity|indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity|indoleglycerolphosphate aldolase activity|tryptophan synthase alpha activity|tryptophan synthase alpha subunit activity http://purl.obolibrary.org/obo/GO_0033984 GO:0018343 biolink:BiologicalProcess protein farnesylation The covalent attachment of a farnesyl group to a protein. go.json C-terminal protein farnesylation|protein amino acid farnesylation http://purl.obolibrary.org/obo/GO_0018343 gocheck_do_not_annotate GO:0033983 biolink:MolecularActivity diaminobutyrate decarboxylase activity Catalysis of the reaction: L-2,4-diaminobutyrate + H+ = 1,3-diaminopropane + CO2. EC:4.1.1.86|KEGG_REACTION:R07650|MetaCyc:4.1.1.86-RXN|RHEA:15689 go.json DABA DC|L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity|L-2,4-diaminobutanoate carboxy-lyase activity|L-2,4-diaminobutyrate decarboxylase activity http://purl.obolibrary.org/obo/GO_0033983 GO:0018346 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018346 GO:0033982 biolink:MolecularActivity 3-dehydro-L-gulonate-6-phosphate decarboxylase activity Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2. EC:4.1.1.85|KEGG_REACTION:R07125|MetaCyc:RXN0-705|RHEA:14353 go.json 3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity|3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity|3-keto-L-gulonate 6-phosphate decarboxylase activity|KGPDC|SgaH|SgbH|UlaD http://purl.obolibrary.org/obo/GO_0033982 GO:0018345 biolink:BiologicalProcess protein palmitoylation The covalent attachment of a palmitoyl group to a protein. go.json protein amino acid palmitoylation http://purl.obolibrary.org/obo/GO_0018345 gocheck_do_not_annotate GO:0033981 biolink:MolecularActivity D-dopachrome decarboxylase activity Catalysis of the reaction: D-dopachrome + H+ = 5,6-dihydroxyindole + CO2. EC:4.1.1.84|KEGG_REACTION:R07313|MetaCyc:4.1.1.84-RXN|RHEA:18441 go.json D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity|D-dopachrome carboxy-lyase activity|D-dopachrome tautomerase activity|D-tautomerase activity|dopachrome conversion activity|dopachrome decarboxylase activity|phenylpyruvate tautomerase II activity http://purl.obolibrary.org/obo/GO_0033981 GO:0018340 biolink:BiologicalProcess peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine. RESID:AA0264 go.json peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine|peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine|peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine http://purl.obolibrary.org/obo/GO_0018340 gocheck_do_not_annotate GO:0033980 biolink:MolecularActivity phosphonopyruvate decarboxylase activity Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde. EC:4.1.1.82|KEGG_REACTION:R04053|MetaCyc:4.1.1.82-RXN|RHEA:20768 go.json 3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity|3-phosphonopyruvate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0033980 GO:0018342 biolink:BiologicalProcess protein prenylation The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added. go.json C-terminal protein prenylation|protein amino acid prenylation http://purl.obolibrary.org/obo/GO_0018342 gocheck_do_not_annotate GO:0018341 biolink:BiologicalProcess peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine. go.json peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis http://purl.obolibrary.org/obo/GO_0018341 gocheck_do_not_annotate GO:0018360 biolink:BiologicalProcess protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine. RESID:AA0271 go.json protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine http://purl.obolibrary.org/obo/GO_0018360 gocheck_do_not_annotate GO:0043360 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043360 GO:0033979 biolink:BiologicalProcess box H/ACA RNA metabolic process The chemical reactions and pathways involving box H/ACA type small nucleolar RNA. go.json box H/ACA sRNA metabolic process|box H/ACA snoRNA metabolic process http://purl.obolibrary.org/obo/GO_0033979 GO:0033978 biolink:MolecularActivity phosphonopyruvate hydrolase activity Catalysis of the reaction: 3-phosphonopyruvate + H2O = phosphate + pyruvate. EC:3.11.1.3|KEGG_REACTION:R08200|MetaCyc:3.11.1.3-RXN|RHEA:16673 go.json PPH http://purl.obolibrary.org/obo/GO_0033978 GO:0033977 biolink:MolecularActivity 2-haloacid dehalogenase (configuration-retaining) activity Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. EC:3.8.1.11|MetaCyc:3.8.1.11-RXN|RHEA:12072 go.json 2-haloalkanoic acid dehalogenase activity|2-haloalkanoid acid halidohydrolase activity|DL-2-haloacid dehalogenase activity|DL-DEXr http://purl.obolibrary.org/obo/GO_0033977 GO:0033976 biolink:MolecularActivity 2-haloacid dehalogenase (configuration-inverting) activity Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide. MetaCyc:2-HALOACID-DEHALOGENASE-RXN|MetaCyc:RXN-6264 go.json 2-haloalkanoic acid dehalogenase activity|2-haloalkanoid acid halidohydrolase activity|DL-2-haloacid dehalogenase (inversion of configuration) activity|DL-2-haloacid dehalogenase activity|DL-2-haloacid halidohydrolase (inversion of configuration) activity|DL-DEXi http://purl.obolibrary.org/obo/GO_0033976 GO:0033975 biolink:MolecularActivity (R)-2-haloacid dehalogenase activity Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide. EC:3.8.1.9|MetaCyc:RXN-6264|RHEA:22188 go.json (R)-2-haloacid halidohydrolase activity|2-haloalkanoic acid dehalogenase activity|2-haloalkanoid acid halidohydrolase activity|D-2-haloacid dehalogenase activity|D-DEX http://purl.obolibrary.org/obo/GO_0033975 GO:0043366 biolink:BiologicalProcess beta selection The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell. go.json http://purl.obolibrary.org/obo/GO_0043366 GO:0043365 biolink:MolecularActivity [formate-C-acetyltransferase]-activating enzyme activity Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. EC:1.97.1.4|MetaCyc:TDCEACT-RXN|RHEA:19225 go.json PFL activase activity|PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity|[pyruvate formate-lyase]-activating enzyme activity|formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)|formate acetyltransferase activating enzyme activity|formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity|formate-C-acetyltransferase-activating enzyme|pyruvate formate-lyase-activating enzyme http://purl.obolibrary.org/obo/GO_0043365 GO:0043368 biolink:BiologicalProcess positive T cell selection The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. go.json positive T lymphocyte selection|positive T-cell selection|positive T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0043368 GO:0043367 biolink:BiologicalProcess CD4-positive, alpha-beta T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. go.json CD4-positive, alpha beta T cell development|CD4-positive, alpha beta T cell differentiation|CD4-positive, alpha-beta T lymphocyte differentiation|CD4-positive, alpha-beta T-cell differentiation|CD4-positive, alpha-beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043367 GO:0043362 biolink:BiologicalProcess nucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. go.json nucleate RBC maturation|nucleate red blood cell maturation http://purl.obolibrary.org/obo/GO_0043362 GO:0043361 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043361 GO:0043364 biolink:MolecularActivity glycyl-radical enzyme activating activity Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM). EC:1.97.1.- go.json catalysis of free radical formation http://purl.obolibrary.org/obo/GO_0043364 goslim_pir GO:0043363 biolink:BiologicalProcess nucleate erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. go.json nucleate RBC differentiation|nucleate red blood cell differentiation http://purl.obolibrary.org/obo/GO_0043363 GO:0018359 biolink:BiologicalProcess protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine. RESID:AA0266 go.json protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine http://purl.obolibrary.org/obo/GO_0018359 gocheck_do_not_annotate GO:0018358 biolink:BiologicalProcess protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine. RESID:AA0133 go.json http://purl.obolibrary.org/obo/GO_0018358 gocheck_do_not_annotate GO:0043369 biolink:BiologicalProcess CD4-positive or CD8-positive, alpha-beta T cell lineage commitment The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. go.json CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment|CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment|CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment|CD4-positive/CD8-positive, alpha-beta T cell lineage commitment http://purl.obolibrary.org/obo/GO_0043369 GO:0018355 biolink:BiologicalProcess protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine. go.json http://purl.obolibrary.org/obo/GO_0018355 gocheck_do_not_annotate GO:0033974 biolink:MolecularActivity nucleoside phosphoacylhydrolase activity Catalysis of the hydrolysis of mixed phospho-anhydride bonds. EC:3.6.1.24|MetaCyc:3.6.1.24-RXN go.json nucleoside-5'-phosphoacylate acylhydrolase activity http://purl.obolibrary.org/obo/GO_0033974 GO:0033973 biolink:MolecularActivity dCTP deaminase (dUMP-forming) activity Catalysis of the reaction: dCTP + 2 H2O = diphosphate + dUMP + H+ + NH4. EC:3.5.4.30|KEGG_REACTION:R07307|MetaCyc:3.5.4.30-RXN|RHEA:19205 go.json dCTP aminohydrolase (dUMP-forming) activity http://purl.obolibrary.org/obo/GO_0033973 GO:0018354 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018354 GO:0033972 biolink:MolecularActivity proclavaminate amidinohydrolase activity Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea. EC:3.5.3.22|KEGG_REACTION:R05357|MetaCyc:3.5.3.22-RXN|RHEA:17001 go.json PAH|proclavaminate amidino hydrolase activity|proclavaminic acid amidino hydrolase activity http://purl.obolibrary.org/obo/GO_0033972 GO:0018357 biolink:BiologicalProcess protein-phycourobilin linkage via phycourobilin-bis-L-cysteine The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine. RESID:AA0260 go.json http://purl.obolibrary.org/obo/GO_0018357 gocheck_do_not_annotate GO:0033971 biolink:MolecularActivity hydroxyisourate hydrolase activity Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+. EC:3.5.2.17|KEGG_REACTION:R06601|MetaCyc:3.5.2.17-RXN|RHEA:23736 go.json 5-hydroxyisourate amidohydrolase activity|5-hydroxyisourate hydrolase activity|HIUHase activity http://purl.obolibrary.org/obo/GO_0033971 GO:0018356 biolink:BiologicalProcess protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine. RESID:AA0258 go.json http://purl.obolibrary.org/obo/GO_0018356 gocheck_do_not_annotate GO:0018351 biolink:BiologicalProcess obsolete peptidyl-cysteine esterification OBSOLETE. The addition of an ester group to a cysteine residue in a protein. go.json True http://purl.obolibrary.org/obo/GO_0018351 GO:0033970 biolink:MolecularActivity N-malonylurea hydrolase activity Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = H+ + malonate + urea. EC:3.5.1.95|KEGG_REACTION:R07629|MetaCyc:3.5.1.95-RXN|RHEA:17361 go.json 3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity|ureidomalonase activity http://purl.obolibrary.org/obo/GO_0033970 GO:0018350 biolink:BiologicalProcess obsolete protein esterification OBSOLETE. The addition of an ester group to a protein amino acid. go.json protein amino acid esterification True http://purl.obolibrary.org/obo/GO_0018350 GO:0018353 biolink:BiologicalProcess protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine. RESID:AA0131 go.json http://purl.obolibrary.org/obo/GO_0018353 gocheck_do_not_annotate GO:0018352 biolink:BiologicalProcess protein-pyridoxal-5-phosphate linkage The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate. go.json http://purl.obolibrary.org/obo/GO_0018352 gocheck_do_not_annotate GO:0043371 biolink:BiologicalProcess negative regulation of CD4-positive, alpha-beta T cell differentiation Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. go.json down regulation of CD4-positive, alpha beta T cell differentiation|down-regulation of CD4-positive, alpha beta T cell differentiation|downregulation of CD4-positive, alpha beta T cell differentiation|inhibition of CD4-positive, alpha beta T cell differentiation|negative regulation of CD4-positive T-cell differentiation|negative regulation of CD4-positive T-lymphocyte differentiation|negative regulation of CD4-positive, alpha beta T cell development|negative regulation of CD4-positive, alpha beta T lymphocyte differentiation|negative regulation of CD4-positive, alpha beta T-cell differentiation|negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043371 GO:0033969 biolink:MolecularActivity gamma-glutamyl-gamma-aminobutyrate hydrolase activity Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate. EC:3.5.1.94|KEGG_REACTION:R07419|MetaCyc:RXN0-3942|RHEA:19737 go.json 4-(glutamylamino)butanoate amidohydrolase activity|PuuD|YcjL|gamma-glutamyl-GABA hydrolase activity http://purl.obolibrary.org/obo/GO_0033969 GO:0033968 biolink:MolecularActivity glutaryl-7-aminocephalosporanic-acid acylase activity Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate. EC:3.5.1.93|MetaCyc:3.5.1.93-RXN|RHEA:23508 go.json (7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity|7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity|CA|GA|GCA|GL-7-ACA acylase activity|cephalosporin C acylase activity|cephalosporin acylase activity|glutaryl-7-ACA acylase activity|glutaryl-7-aminocephalosporanic acid acylase activity http://purl.obolibrary.org/obo/GO_0033968 GO:0043370 biolink:BiologicalProcess regulation of CD4-positive, alpha-beta T cell differentiation Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. go.json regulation of CD4-positive T lymphocyte differentiation|regulation of CD4-positive T-cell differentiation|regulation of CD4-positive T-lymphocyte differentiation|regulation of CD4-positive, alpha beta T cell development|regulation of CD4-positive, alpha beta T cell differentiation|regulation of CD4-positive, alpha beta T lymphocyte differentiation|regulation of CD4-positive, alpha beta T-cell differentiation|regulation of CD4-positive, alpha beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043370 GO:0033967 biolink:BiologicalProcess box C/D RNA metabolic process The chemical reactions and pathways involving box C/D type small nucleolar RNA. go.json box C/D sRNA metabolic process|box C/D snoRNA metabolic process http://purl.obolibrary.org/obo/GO_0033967 GO:0033966 biolink:MolecularActivity N-substituted formamide deformylase activity Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine. MetaCyc:3.5.1.91-RXN|RHEA:12096 go.json N-benzylformamide amidohydrolase activity|NfdA http://purl.obolibrary.org/obo/GO_0033966 GO:0033965 biolink:MolecularActivity aculeacin-A deacylase activity Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain. EC:3.5.1.70|MetaCyc:3.5.1.70-RXN go.json aculeacin A acylase activity|aculeacin-A amidohydrolase activity http://purl.obolibrary.org/obo/GO_0033965 GO:0033964 biolink:MolecularActivity glycosphingolipid deacylase activity Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives. EC:3.5.1.69|MetaCyc:3.5.1.69-RXN go.json glycosphingolipid amidohydrolase activity|glycosphingolipid ceramide deacylase activity http://purl.obolibrary.org/obo/GO_0033964 GO:0043377 biolink:BiologicalProcess negative regulation of CD8-positive, alpha-beta T cell differentiation Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation. go.json down regulation of CD8-positive, alpha-beta T cell differentiation|down-regulation of CD8-positive, alpha-beta T cell differentiation|downregulation of CD8-positive, alpha-beta T cell differentiation|inhibition of CD8-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive T lymphocyte differentiation|negative regulation of CD8-positive T-cell differentiation|negative regulation of CD8-positive T-lymphocyte differentiation|negative regulation of CD8-positive, alpha beta T lymphocyte differentiation|negative regulation of CD8-positive, alpha beta T-cell differentiation|negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation|negative regulation of CD8-positive, alpha-beta T cell development http://purl.obolibrary.org/obo/GO_0043377 GO:0043376 biolink:BiologicalProcess regulation of CD8-positive, alpha-beta T cell differentiation Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation. go.json regulation of CD8-positive T lymphocyte differentiation|regulation of CD8-positive T-cell differentiation|regulation of CD8-positive T-lymphocyte differentiation|regulation of CD8-positive, alpha beta T lymphocyte differentiation|regulation of CD8-positive, alpha beta T-cell differentiation|regulation of CD8-positive, alpha beta T-lymphocyte differentiation|regulation of CD8-positive, alpha-beta T cell development http://purl.obolibrary.org/obo/GO_0043376 GO:0043379 biolink:BiologicalProcess memory T cell differentiation The process in which a newly activated T cell acquires specialized features of a memory T cell. go.json memory T cell development|memory T lymphocyte differentiation|memory T-cell differentiation|memory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043379 GO:0043378 biolink:BiologicalProcess positive regulation of CD8-positive, alpha-beta T cell differentiation Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation. go.json activation of CD8-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive T lymphocyte differentiation|positive regulation of CD8-positive T-cell differentiation|positive regulation of CD8-positive T-lymphocyte differentiation|positive regulation of CD8-positive, alpha beta T lymphocyte differentiation|positive regulation of CD8-positive, alpha beta T-cell differentiation|positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation|positive regulation of CD8-positive, alpha-beta T cell development|stimulation of CD8-positive, alpha-beta T cell differentiation|up regulation of CD8-positive, alpha-beta T cell differentiation|up-regulation of CD8-positive, alpha-beta T cell differentiation|upregulation of CD8-positive, alpha-beta T cell differentiation http://purl.obolibrary.org/obo/GO_0043378 GO:0043373 biolink:BiologicalProcess CD4-positive, alpha-beta T cell lineage commitment The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell. go.json CD4-positive, alpha-beta T lymphocyte lineage commitment|CD4-positive, alpha-beta T-cell lineage commitment|CD4-positive, alpha-beta T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0043373 GO:0043372 biolink:BiologicalProcess positive regulation of CD4-positive, alpha-beta T cell differentiation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation. go.json activation of CD4-positive, alpha beta T cell differentiation|positive regulation of CD4-positive T lymphocyte differentiation|positive regulation of CD4-positive T-cell differentiation|positive regulation of CD4-positive T-lymphocyte differentiation|positive regulation of CD4-positive, alpha beta T cell development|positive regulation of CD4-positive, alpha beta T cell differentiation|positive regulation of CD4-positive, alpha beta T lymphocyte differentiation|positive regulation of CD4-positive, alpha beta T-cell differentiation|positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation|stimulation of CD4-positive, alpha beta T cell differentiation|up regulation of CD4-positive, alpha beta T cell differentiation|up-regulation of CD4-positive, alpha beta T cell differentiation|upregulation of CD4-positive, alpha beta T cell differentiation http://purl.obolibrary.org/obo/GO_0043372 GO:0043375 biolink:BiologicalProcess CD8-positive, alpha-beta T cell lineage commitment The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell. go.json CD8-positive, alpha-beta T cell fate commitment|CD8-positive, alpha-beta T lymphocyte lineage commitment|CD8-positive, alpha-beta T-cell lineage commitment|CD8-positive, alpha-beta T-lymphocyte lineage commitment http://purl.obolibrary.org/obo/GO_0043375 GO:0043374 biolink:BiologicalProcess CD8-positive, alpha-beta T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. go.json CD8-positive, alpha-beta T cell development|CD8-positive, alpha-beta T lymphocyte differentiation|CD8-positive, alpha-beta T-cell differentiation|CD8-positive, alpha-beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043374 GO:0018329 biolink:BiologicalProcess obsolete enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine OBSOLETE. The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase. RESID:AA0227 go.json True http://purl.obolibrary.org/obo/GO_0018329 GO:0018326 biolink:BiologicalProcess obsolete enzyme active site formation via S-acetyl-L-cysteine OBSOLETE. The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine. RESID:AA0056 go.json True http://purl.obolibrary.org/obo/GO_0018326 GO:0018325 biolink:BiologicalProcess obsolete enzyme active site formation via S-phospho-L-cysteine OBSOLETE. The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine. RESID:AA0034 go.json True http://purl.obolibrary.org/obo/GO_0018325 GO:0018328 biolink:BiologicalProcess obsolete enzyme active site formation via 3'-phospho-L-histidine OBSOLETE. The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). RESID:AA0036 go.json True http://purl.obolibrary.org/obo/GO_0018328 GO:0018327 biolink:BiologicalProcess obsolete enzyme active site formation via 1'-phospho-L-histidine OBSOLETE. The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine). RESID:AA0035 go.json True http://purl.obolibrary.org/obo/GO_0018327 GO:0033963 biolink:MolecularActivity cholesterol-5,6-oxide hydrolase activity Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol. EC:3.3.2.11|MetaCyc:RXN-8650|MetaCyc:RXN-8651 go.json 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity|ChEH|cholesterol-epoxide hydrolase activity http://purl.obolibrary.org/obo/GO_0033963 GO:0018322 biolink:BiologicalProcess obsolete protein tyrosinylation OBSOLETE. The addition of a tyrosine molecule to a protein amino acid. go.json protein amino acid tyrosinylation True http://purl.obolibrary.org/obo/GO_0018322 GO:0018321 biolink:BiologicalProcess protein glucuronylation The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose. go.json protein amino acid glucuronylation http://purl.obolibrary.org/obo/GO_0018321 GO:0033962 biolink:BiologicalProcess P-body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. go.json P body assembly|P body biogenesis|cytoplasmic mRNA processing body assembly http://purl.obolibrary.org/obo/GO_0033962 GO:0018324 biolink:BiologicalProcess obsolete enzyme active site formation via L-cysteine sulfenic acid OBSOLETE. The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase. RESID:AA0205 go.json enzyme active site formation via L-cysteine sulphenic acid True http://purl.obolibrary.org/obo/GO_0018324 GO:0033961 biolink:MolecularActivity cis-stilbene-oxide hydrolase activity Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. EC:3.3.2.9|MetaCyc:3.3.2.9-RXN|RHEA:23900|Reactome:R-HSA-5694077 go.json arene-oxide hydratase activity|aryl epoxide hydrase activity|benzo(a)pyrene-4,5-epoxide hydratase activity|benzo[a]pyrene-4,5-oxide hydratase activity|cis-epoxide hydrolase activity|epoxide hydrase activity|epoxide hydratase activity|mEH|microsomal epoxide hydrase activity|microsomal epoxide hydratase activity|microsomal epoxide hydrolase activity http://purl.obolibrary.org/obo/GO_0033961 goslim_chembl GO:0033960 biolink:MolecularActivity N-methyl nucleosidase activity Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + H+ + ribofuranose. EC:3.2.2.25|KEGG_REACTION:R07918|MetaCyc:RXN-7597|RHEA:10880 go.json 7-methylxanthosine nucleosidase activity|7-methylxanthosine ribohydrolase activity|N-MeNase activity|N-methyl nucleoside hydrolase activity|methylpurine nucleosidase activity http://purl.obolibrary.org/obo/GO_0033960 GO:0018323 biolink:BiologicalProcess obsolete enzyme active site formation via L-cysteine sulfinic acid OBSOLETE. The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid. RESID:AA0262 go.json enzyme active site formation via L-cysteine sulphinic acid True http://purl.obolibrary.org/obo/GO_0018323 GO:0018320 biolink:BiologicalProcess obsolete enzyme active site formation via S-methyl-L-cysteine OBSOLETE. The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine. RESID:AA0234 go.json True http://purl.obolibrary.org/obo/GO_0018320 GO:0043380 biolink:BiologicalProcess regulation of memory T cell differentiation Any process that modulates the frequency, rate, or extent of memory T cell differentiation. go.json regulation of memory T cell development|regulation of memory T lymphocyte differentiation|regulation of memory T-cell differentiation|regulation of memory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043380 GO:0033959 biolink:MolecularActivity deoxyribodipyrimidine endonucleosidase activity Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue. EC:3.2.2.17|MetaCyc:3.2.2.17-RXN go.json PD-DNA glycosylase activity|T4-induced UV endonuclease activity|deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity|deoxyribonucleate pyrimidine dimer glycosidase activity|endonuclease V activity|pyrimidine dimer DNA glycosylase activity|pyrimidine dimer DNA-glycosylase activity http://purl.obolibrary.org/obo/GO_0033959 GO:0043382 biolink:BiologicalProcess positive regulation of memory T cell differentiation Any process that activates or increases the frequency, rate or extent of memory T cell differentiation. go.json activation of memory T cell differentiation|positive regulation of memory T cell development|positive regulation of memory T lymphocyte differentiation|positive regulation of memory T-cell differentiation|positive regulation of memory T-lymphocyte differentiation|stimulation of memory T cell differentiation|up regulation of memory T cell differentiation|up-regulation of memory T cell differentiation|upregulation of memory T cell differentiation http://purl.obolibrary.org/obo/GO_0043382 GO:0033958 biolink:MolecularActivity DNA-deoxyinosine glycosylase activity Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine. EC:3.2.2.15|MetaCyc:3.2.2.15-RXN go.json DNA(hypoxanthine) glycohydrolase activity|DNA-deoxyinosine deoxyribohydrolase activity|DNA-deoxyinosine glycosidase activity|deoxyribonucleic acid glycosylase activity|hypoxanthine-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0033958 GO:0043381 biolink:BiologicalProcess negative regulation of memory T cell differentiation Any process that stops, prevents, or reduces the rate of memory T cell differentiation. go.json down regulation of memory T cell differentiation|down-regulation of memory T cell differentiation|downregulation of memory T cell differentiation|inhibition of memory T cell differentiation|negative regulation of memory T cell development|negative regulation of memory T lymphocyte differentiation|negative regulation of memory T-cell differentiation|negative regulation of memory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0043381 GO:0033957 biolink:MolecularActivity lambda-carrageenase activity Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S. EC:3.2.1.162|MetaCyc:3.2.1.162-RXN go.json endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity http://purl.obolibrary.org/obo/GO_0033957 GO:0033956 biolink:MolecularActivity beta-apiosyl-beta-glucosidase activity Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose. EC:3.2.1.161|MetaCyc:3.2.1.161-RXN|MetaCyc:RXN-9156|RHEA:21488 go.json 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity|furcatin hydrolase activity|isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity|isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity http://purl.obolibrary.org/obo/GO_0033956 GO:0033955 biolink:BiologicalProcess obsolete mitochondrial DNA inheritance OBSOLETE. The process in which copies of the mitochondrial genome are distributed into daughter mitochondria upon mitochondrial fission. go.json mitochondrial DNA segregation|mitochondrial chromosome segregation True http://purl.obolibrary.org/obo/GO_0033955 GO:0033954 biolink:MolecularActivity alpha-neoagaro-oligosaccharide hydrolase activity Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose. EC:3.2.1.159|MetaCyc:3.2.1.159-RXN go.json alpha-NAOS hydrolase activity|alpha-neoagaro-oligosaccharide 3-glycohydrolase activity|alpha-neoagarooligosaccharide hydrolase activity http://purl.obolibrary.org/obo/GO_0033954 GO:0033953 biolink:MolecularActivity alpha-agarase activity Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product. EC:3.2.1.158|MetaCyc:3.2.1.158-RXN go.json agarase A33 activity|agarase activity|agarose 3-glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0033953 GO:0043388 biolink:BiologicalProcess positive regulation of DNA binding Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). go.json activation of DNA binding|stimulation of DNA binding|up regulation of DNA binding|up-regulation of DNA binding|upregulation of DNA binding http://purl.obolibrary.org/obo/GO_0043388 gocheck_do_not_annotate GO:0043387 biolink:BiologicalProcess mycotoxin catabolic process The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus. go.json mycotoxin breakdown|mycotoxin catabolism|mycotoxin degradation http://purl.obolibrary.org/obo/GO_0043387 GO:0043389 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043389 GO:0043384 biolink:CellularComponent pre-T cell receptor complex A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins. go.json pre-T lymphocyte receptor complex|pre-T-cell receptor complex|pre-T-lymphocyte receptor complex|pre-TCR complex http://purl.obolibrary.org/obo/GO_0043384 GO:0043383 biolink:BiologicalProcess negative T cell selection The process of elimination of immature T cells which react strongly with self-antigens. go.json negative T lymphocyte selection|negative T-cell selection|negative T-lymphocyte selection http://purl.obolibrary.org/obo/GO_0043383 GO:0043386 biolink:BiologicalProcess mycotoxin biosynthetic process The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus. go.json mycotoxin anabolism|mycotoxin biosynthesis|mycotoxin formation|mycotoxin synthesis http://purl.obolibrary.org/obo/GO_0043386 GO:0043385 biolink:BiologicalProcess mycotoxin metabolic process The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus. go.json mycotoxin metabolism http://purl.obolibrary.org/obo/GO_0043385 GO:0018337 biolink:BiologicalProcess obsolete enzyme active site formation via L-2',4',5'-topaquinone OBSOLETE. (Was not defined before being made obsolete). go.json enzyme active site formation via L-2',4',5'-topaquinone True http://purl.obolibrary.org/obo/GO_0018337 GO:0018336 biolink:BiologicalProcess peptidyl-tyrosine hydroxylation The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine. go.json http://purl.obolibrary.org/obo/GO_0018336 gocheck_do_not_annotate GO:0018339 biolink:BiologicalProcess peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12. RESID:AA0232 go.json peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid|peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid|peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid|peptidyl-aspartic acid methylthiolation http://purl.obolibrary.org/obo/GO_0018339 gocheck_do_not_annotate GO:0018338 biolink:BiologicalProcess obsolete protein amino acid cinnamylation OBSOLETE. The modification of a protein amino acid by cinnamylation. go.json protein amino acid cinnamylation True http://purl.obolibrary.org/obo/GO_0018338 GO:0033952 biolink:MolecularActivity iota-carrageenase activity Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans. EC:3.2.1.157|MetaCyc:3.2.1.157-RXN go.json iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity http://purl.obolibrary.org/obo/GO_0033952 GO:0018333 biolink:BiologicalProcess obsolete enzyme active site formation via O-phospho-L-threonine OBSOLETE. The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine. RESID:AA0038 go.json True http://purl.obolibrary.org/obo/GO_0018333 GO:0033951 biolink:MolecularActivity oligosaccharide reducing-end xylanase activity Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides. EC:3.2.1.156|MetaCyc:3.2.1.156-RXN go.json Rex|beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity|reducing end xylose-releasing exo-oligoxylanase activity http://purl.obolibrary.org/obo/GO_0033951 GO:0018332 biolink:BiologicalProcess obsolete enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine OBSOLETE. The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I. RESID:AA0267 go.json True http://purl.obolibrary.org/obo/GO_0018332 GO:0018335 biolink:BiologicalProcess protein succinylation The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue. go.json protein amino acid succinylation http://purl.obolibrary.org/obo/GO_0018335 gocheck_do_not_annotate GO:0033950 biolink:MolecularActivity xyloglucan-specific exo-beta-1,4-glucanase activity Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan. EC:3.2.1.155|MetaCyc:3.2.1.155-RXN go.json Cel74A|[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity http://purl.obolibrary.org/obo/GO_0033950 GO:0018334 biolink:BiologicalProcess obsolete enzyme active site formation via O4'-phospho-L-tyrosine OBSOLETE. The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine. RESID:AA0039 go.json True http://purl.obolibrary.org/obo/GO_0018334 GO:0018331 biolink:BiologicalProcess obsolete enzyme active site formation via O-phospho-L-serine OBSOLETE. The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine. RESID:AA0037 go.json True http://purl.obolibrary.org/obo/GO_0018331 GO:0018330 biolink:BiologicalProcess obsolete enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine OBSOLETE. The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme. RESID:AA0228 go.json True http://purl.obolibrary.org/obo/GO_0018330 GO:0033949 biolink:MolecularActivity fructan beta-(2,6)-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans. EC:3.2.1.154|MetaCyc:3.2.1.154-RXN go.json 6-FEH|beta-(2,6)-D-fructan fructohydrolase activity|beta-(2,6)-fructan exohydrolase activity http://purl.obolibrary.org/obo/GO_0033949 GO:0043391 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043391 GO:0033948 biolink:MolecularActivity fructan beta-(2,1)-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans. EC:3.2.1.153|MetaCyc:3.2.1.153-RXN go.json 1-FEH II|1-FEH w1|1-FEH w2|1-fructan exohydrolase activity|beta-(2,1)-D-fructan fructohydrolase activity|beta-(2,1)-fructan exohydrolase activity|beta-(2,1)-linkage-specific fructan-beta-fructosidase activity http://purl.obolibrary.org/obo/GO_0033948 GO:0043390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043390 GO:0033947 biolink:MolecularActivity mannosylglycoprotein endo-beta-mannosidase activity Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences. EC:3.2.1.152|MetaCyc:3.2.1.152-RXN go.json endo-beta-mannosidase activity http://purl.obolibrary.org/obo/GO_0033947 GO:0043393 biolink:BiologicalProcess regulation of protein binding Any process that modulates the frequency, rate or extent of protein binding. go.json http://purl.obolibrary.org/obo/GO_0043393 gocheck_do_not_annotate GO:0043392 biolink:BiologicalProcess negative regulation of DNA binding Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). go.json down regulation of DNA binding|down-regulation of DNA binding|downregulation of DNA binding|inhibition of DNA binding http://purl.obolibrary.org/obo/GO_0043392 gocheck_do_not_annotate GO:0033946 biolink:MolecularActivity xyloglucan-specific endo-beta-1,4-glucanase activity Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan. EC:3.2.1.151|MetaCyc:3.2.1.151-RXN go.json 1,4-beta-D-glucan glucanohydrolase activity|XEG|XH|[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity|xyloglucan endo-beta-1,4-glucanase activity|xyloglucanase activity|xyloglucanendohydrolase activity http://purl.obolibrary.org/obo/GO_0033946 GO:0033945 biolink:MolecularActivity oligoxyloglucan reducing-end-specific cellobiohydrolase activity Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted. EC:3.2.1.150|MetaCyc:3.2.1.150-RXN go.json oligoxyloglucan reducing end-specific cellobiohydrolase activity|oligoxyloglucan reducing-end cellobiohydrolase activity http://purl.obolibrary.org/obo/GO_0033945 GO:0008989 biolink:MolecularActivity rRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine. go.json S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity|S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity|ribosomal ribonucleate guanine 1-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008989 GO:0008988 biolink:MolecularActivity rRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. go.json ErmC 23S rRNA methyltransferase|S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity|S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity|gene ksgA methyltransferase|ribonucleic acid-adenine (N(6)) methylase activity|ribonucleic acid-adenine (N6) methylase activity|ribosomal ribonucleate adenine 6-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008988 GO:0033944 biolink:MolecularActivity beta-galactofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose. EC:3.2.1.146|MetaCyc:3.2.1.146-RXN go.json beta-D-galactofuranosidase activity|beta-D-galactofuranoside hydrolase activity|exo-beta-D-galactofuranosidase activity|exo-beta-galactofuranosidase activity http://purl.obolibrary.org/obo/GO_0033944 GO:0033943 biolink:MolecularActivity galactan 1,3-beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans. EC:3.2.1.145|MetaCyc:3.2.1.145-RXN go.json galactan (1,3)-beta-D-galactosidase activity|galactan (1->3)-beta-D-galactosidase activity http://purl.obolibrary.org/obo/GO_0033943 GO:0008987 biolink:MolecularActivity quinolinate synthetase A activity Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate. MetaCyc:QUINOLINATE-SYNTHA-RXN|RHEA:25888 go.json http://purl.obolibrary.org/obo/GO_0008987 GO:0008986 biolink:MolecularActivity pyruvate, water dikinase activity Catalysis of the reaction: ATP + H2O + pyruvate = AMP + 3 H+ + phosphate + phosphoenolpyruvate. EC:2.7.9.2|KEGG_REACTION:R00199|MetaCyc:PEPSYNTH-RXN|RHEA:11364 go.json ATP:pyruvate, water phosphotransferase activity|PEP synthase activity|PEP synthetase activity|phoephoenolpyruvate synthetase activity|phosphoenolpyruvate synthase activity|phosphoenolpyruvic synthase activity|phosphopyruvate synthetase activity|pyruvate,water dikinase activity|pyruvate-water dikinase (phosphorylating)|water pyruvate dikinase activity http://purl.obolibrary.org/obo/GO_0008986 GO:0033942 biolink:MolecularActivity 4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan. EC:3.2.1.141|MetaCyc:3.2.1.141-RXN go.json 4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity|4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity|malto-oligosyltrehalose trehalohydrolase activity|maltooligosyl trehalose trehalohydrolase activity http://purl.obolibrary.org/obo/GO_0033942 GO:0008985 biolink:MolecularActivity obsolete pyruvate dehydrogenase (cytochrome) activity OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1. go.json pyruvate dehydrogenase (cytochrome) activity|pyruvate:ferricytochrome-b1 oxidoreductase activity|pyruvate:ubiquinone-8-oxidoreductase activity|pyruvic (cytochrome b1) dehydrogenase activity True http://purl.obolibrary.org/obo/GO_0008985 GO:0043399 biolink:MolecularActivity tRNA A64-2'-O-ribosylphosphate transferase activity Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA. go.json initiator tRNA phosphoribosyl-transferase activity http://purl.obolibrary.org/obo/GO_0043399 GO:0008984 biolink:MolecularActivity protein-glutamate methylesterase activity Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. EC:3.1.1.61|MetaCyc:MCPMETEST-RXN|RESID:AA0072|RHEA:23236 go.json CheB methylesterase activity|chemotaxis-specific methylesterase activity|methyl-accepting chemotaxis protein methyl-esterase activity|methylesterase CheB activity|protein-L-glutamate-5-O-methyl-ester acylhydrolase activity|protein-L-glutamate-O5-methyl-ester acylhydrolase activity http://purl.obolibrary.org/obo/GO_0008984 GO:0043398 biolink:MolecularActivity HLH domain binding Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. go.json http://purl.obolibrary.org/obo/GO_0043398 GO:0008983 biolink:MolecularActivity protein-glutamate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. EC:2.1.1.80|MetaCyc:CHER-RXN|RESID:AA0072|RHEA:24452 go.json MCP methyltransferase I|MCP methyltransferase II|S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity|S-adenosylmethionine-glutamyl methyltransferase activity|S-adenosylmethionine:protein-carboxyl O-methyltransferase activity|methyl-accepting chemotaxis protein O-methyltransferase activity|methyl-accepting chemotaxis protein methyltransferase II|protein O-methyltransferase activity|protein carboxyl-O-methyltransferase activity|protein carboxyl-methylase activity|protein carboxylmethyltransferase II|protein carboxymethylase activity|protein carboxymethyltransferase activity|protein glutamate O-methylase activity|protein glutamate O-methyltransferase activity|protein methylase II|protein(aspartate)methyltransferase activity|protein(carboxyl)methyltransferase activity http://purl.obolibrary.org/obo/GO_0008983 GO:0008982 biolink:MolecularActivity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. TC:4.A go.json PEP--sugar phosphotransferase enzyme II activity|PEP-dependent phosphotransferase enzyme II|PTS permease activity|PTS transporter|enzyme II of the phosphotransferase system|phosphoenolpyruvate-sugar phosphotransferase enzyme II|phosphohistidinoprotein-hexose phosphotransferase activity|phosphoprotein factor-hexose phosophotransferase activity|phosphotransfer-driven group translocator|protein-Np-phosphohistidine-sugar phosphotransferase activity http://purl.obolibrary.org/obo/GO_0008982 GO:0008981 biolink:MolecularActivity obsolete protease IV activity OBSOLETE. (Was not defined before being made obsolete). go.json protease IV activity True http://purl.obolibrary.org/obo/GO_0008981 GO:0043395 biolink:MolecularActivity heparan sulfate proteoglycan binding Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. go.json heparin proteoglycan binding http://purl.obolibrary.org/obo/GO_0043395 GO:0008980 biolink:MolecularActivity propionate kinase activity Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate. EC:2.7.2.15|RHEA:23148 go.json ATP:propanoate phosphotransferase activity|PduW|TdcD|propanoate kinase activity http://purl.obolibrary.org/obo/GO_0008980 GO:0043394 biolink:MolecularActivity proteoglycan binding Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. go.json http://purl.obolibrary.org/obo/GO_0043394 GO:0043397 biolink:BiologicalProcess regulation of corticotropin-releasing hormone secretion Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion. go.json regulation of CRF secretion|regulation of CRH secretion|regulation of corticotropin-releasing factor secretion http://purl.obolibrary.org/obo/GO_0043397 GO:0043396 biolink:BiologicalProcess corticotropin-releasing hormone secretion The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle. go.json CRF secretion|CRH secretion|corticotropin-releasing factor secretion http://purl.obolibrary.org/obo/GO_0043396 GO:0018308 biolink:BiologicalProcess obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase. go.json enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine True http://purl.obolibrary.org/obo/GO_0018308 GO:0018307 biolink:BiologicalProcess obsolete enzyme active site formation OBSOLETE. The modification of part of an enzyme to form the active site. go.json True http://purl.obolibrary.org/obo/GO_0018307 GO:0018309 biolink:BiologicalProcess obsolete protein-FMN linkage OBSOLETE. The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN). go.json True http://purl.obolibrary.org/obo/GO_0018309 GO:0018304 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide. RESID:AA0286 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide http://purl.obolibrary.org/obo/GO_0018304 gocheck_do_not_annotate GO:0018303 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide. RESID:AA0285 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide http://purl.obolibrary.org/obo/GO_0018303 gocheck_do_not_annotate GO:0018306 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide. RESID:AA0289 go.json iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide http://purl.obolibrary.org/obo/GO_0018306 gocheck_do_not_annotate GO:0018305 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide. RESID:AA0288 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide http://purl.obolibrary.org/obo/GO_0018305 gocheck_do_not_annotate GO:0018300 biolink:BiologicalProcess obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide. go.json iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide|iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide True http://purl.obolibrary.org/obo/GO_0018300 GO:0033941 biolink:MolecularActivity mannan exo-1,2-1,6-alpha-mannosidase activity Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose. EC:3.2.1.137|MetaCyc:3.2.1.137-RXN go.json 1,2-1,6-alpha-D-mannan D-mannohydrolase activity|exo-1,2-1,6-alpha-mannosidase activity http://purl.obolibrary.org/obo/GO_0033941 GO:0033940 biolink:MolecularActivity glucuronoarabinoxylan endo-1,4-beta-xylanase activity Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans. EC:3.2.1.136|MetaCyc:3.2.1.136-RXN go.json endoarabinoxylanase activity|feraxan endoxylanase activity|feraxanase activity|glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity|glucuronoxylan xylanohydrolase activity|glucuronoxylan xylohydrolase activity|glucuronoxylanase activity http://purl.obolibrary.org/obo/GO_0033940 GO:0018302 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide. RESID:AA0284 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide http://purl.obolibrary.org/obo/GO_0018302 gocheck_do_not_annotate GO:0018301 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon. RESID:AA0268 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon http://purl.obolibrary.org/obo/GO_0018301 gocheck_do_not_annotate GO:0033938 biolink:MolecularActivity 1,6-alpha-L-fucosidase activity Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin. EC:3.2.1.127|MetaCyc:3.2.1.127-RXN go.json 1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity http://purl.obolibrary.org/obo/GO_0033938 GO:0033937 biolink:MolecularActivity 3-deoxy-2-octulosonidase activity Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides. EC:3.2.1.124|MetaCyc:3.2.1.124-RXN go.json 2-keto-3-deoxyoctonate hydrolase activity|capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity|octulofuranosylono hydrolase activity|octulopyranosylonohydrolase activity|octulosylono hydrolase activity http://purl.obolibrary.org/obo/GO_0033937 GO:0033936 biolink:MolecularActivity polymannuronate hydrolase activity Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate. EC:3.2.1.121|MetaCyc:3.2.1.121-RXN go.json poly(mannuronide) mannuronohydrolase activity|polymannuronic acid polymerase activity http://purl.obolibrary.org/obo/GO_0033936 GO:0033935 biolink:MolecularActivity oligoxyloglucan beta-glycosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends. EC:3.2.1.120|MetaCyc:3.2.1.120-RXN go.json isoprimeverose-producing oligoxyloglucan hydrolase activity|oligoxyloglucan hydrolase activity|oligoxyloglucan xyloglucohydrolase activity http://purl.obolibrary.org/obo/GO_0033935 GO:0033934 biolink:MolecularActivity glucan 1,4-alpha-maltotriohydrolase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends. EC:3.2.1.116|MetaCyc:3.2.1.116-RXN go.json 1,4-alpha-D-glucan maltotriohydrolase activity|exo-maltotriohydrolase activity|maltotriohydrolase activity http://purl.obolibrary.org/obo/GO_0033934 GO:0008999 biolink:MolecularActivity peptide-alanine-alpha-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-peptide = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-peptide. MetaCyc:2.3.1.128-RXN|RHEA:43756 go.json acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity|ribosomal protein S18 acetyltransferase activity|ribosomal-protein-alanine N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0008999 GO:0033933 biolink:MolecularActivity branched-dextran exo-1,2-alpha-glucosidase activity Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose. EC:3.2.1.115|MetaCyc:3.2.1.115-RXN go.json 1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity|dextran 1,2-alpha-glucosidase activity|dextran alpha-1,2 debranching enzyme http://purl.obolibrary.org/obo/GO_0033933 GO:0008998 biolink:MolecularActivity ribonucleoside-triphosphate reductase activity Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin. EC:1.17.4.2|MetaCyc:1.17.4.2-RXN|RHEA:12701 go.json 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity|2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity|ribonucleotide reductase activity http://purl.obolibrary.org/obo/GO_0008998 GO:0033932 biolink:MolecularActivity 1,3-alpha-L-fucosidase activity Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins. EC:3.2.1.111|MetaCyc:3.2.1.111-RXN go.json 3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity|almond emulsin fucosidase I activity http://purl.obolibrary.org/obo/GO_0033932 GO:0008997 biolink:MolecularActivity ribonuclease R activity Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides. EC:3.1.11.- go.json http://purl.obolibrary.org/obo/GO_0008997 GO:0033931 biolink:MolecularActivity endogalactosaminidase activity Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine). EC:3.2.1.109|MetaCyc:3.2.1.109-RXN go.json galactosaminoglycan glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0033931 GO:0008996 biolink:MolecularActivity ribonuclease G activity Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. go.json http://purl.obolibrary.org/obo/GO_0008996 GO:0008995 biolink:MolecularActivity ribonuclease E activity Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. MetaCyc:3.1.26.12-RXN go.json http://purl.obolibrary.org/obo/GO_0008995 GO:0008994 biolink:MolecularActivity rhamnulose-1-phosphate aldolase activity Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. EC:4.1.2.19|MetaCyc:RHAMNULPALDOL-RXN|RHEA:19689 go.json L-rhamnulose 1-phosphate aldolase activity|L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)|L-rhamnulose-1-phosphate lactaldehyde-lyase activity|L-rhamnulose-phosphate aldolase activity|rhamnulose phosphate aldolase activity http://purl.obolibrary.org/obo/GO_0008994 GO:0008993 biolink:MolecularActivity rhamnulokinase activity Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate. EC:2.7.1.5|MetaCyc:RHAMNULOKIN-RXN|RHEA:20117 go.json ATP:L-rhamnulose 1-phosphotransferase activity|L-rhamnulokinase activity|L-rhamnulose kinase activity|RhuK|rhamnulokinase (phosphorylating)|rhamnulose kinase activity http://purl.obolibrary.org/obo/GO_0008993 GO:0008992 biolink:MolecularActivity obsolete repressor LexA activity OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA. go.json LexA repressor|repressor LexA activity|repressor lexA True http://purl.obolibrary.org/obo/GO_0008992 GO:0008991 biolink:MolecularActivity obsolete serine-type signal peptidase activity OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism. go.json serine-type signal peptidase activity True http://purl.obolibrary.org/obo/GO_0008991 GO:0008990 biolink:MolecularActivity rRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. go.json S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity|S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity|ribosomal ribonucleate guanine-2-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008990 GO:0033939 biolink:MolecularActivity xylan alpha-1,2-glucuronosidase activity Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans. EC:3.2.1.131|MetaCyc:3.2.1.131-RXN go.json 1,2-alpha-glucuronidase activity|alpha-(1->2)-glucuronidase activity|xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity http://purl.obolibrary.org/obo/GO_0033939 GO:0018319 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018319 GO:0018318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018318 GO:0018315 biolink:BiologicalProcess molybdenum incorporation into molybdenum-molybdopterin complex The incorporation of molybdenum into a molybdenum-molybdopterin complex. go.json molybdenum incorporation into metallo-pterin complex http://purl.obolibrary.org/obo/GO_0018315 gocheck_do_not_annotate GO:0018314 biolink:BiologicalProcess obsolete protein-pyrroloquinoline-quinone linkage OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine. go.json protein-pyrroloquinoline-quinone linkage True http://purl.obolibrary.org/obo/GO_0018314 GO:0018317 biolink:BiologicalProcess protein C-linked glycosylation via tryptophan The glycosylation of a carbon atom of a peptidyl-tryptophan residue. go.json protein amino acid C-linked glycosylation via tryptophan http://purl.obolibrary.org/obo/GO_0018317 gocheck_do_not_annotate GO:0018316 biolink:BiologicalProcess peptide cross-linking via L-cystine The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain. RESID:AA0025 go.json http://purl.obolibrary.org/obo/GO_0018316 gocheck_do_not_annotate GO:0033930 biolink:MolecularActivity keratan-sulfate endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate. EC:3.2.1.103|MetaCyc:3.2.1.103-RXN go.json endo-beta-galactosidase activity|keratan sulfate endogalactosidase activity|keratan-sulfate 1,4-beta-D-galactanohydrolase activity|keratanase activity http://purl.obolibrary.org/obo/GO_0033930 GO:0018311 biolink:BiologicalProcess obsolete peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine OBSOLETE. The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine. go.json peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine|peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine|peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine True http://purl.obolibrary.org/obo/GO_0018311 GO:0018310 biolink:BiologicalProcess obsolete protein-FMN linkage via S-(6-FMN)-L-cysteine OBSOLETE. The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine. RESID:AA0220 go.json True http://purl.obolibrary.org/obo/GO_0018310 GO:0018313 biolink:BiologicalProcess peptide cross-linking via L-alanyl-5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. RESID:AA0187 go.json http://purl.obolibrary.org/obo/GO_0018313 gocheck_do_not_annotate GO:0018312 biolink:BiologicalProcess obsolete peptidyl-serine ADP-ribosylation OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine. RESID:AA0237 go.json True http://purl.obolibrary.org/obo/GO_0018312 GO:0102232 biolink:MolecularActivity acrolein reductase activity Catalysis of the reaction: acrolein + NADPH + H+ = propanal + NADP. MetaCyc:RXN-12281 go.json http://purl.obolibrary.org/obo/GO_0102232 GO:0102234 biolink:MolecularActivity but-1-en-3-one reductase activity Catalysis of the reaction: buten-2-one + NADPH + H+ = butan-2-one + NADP. MetaCyc:RXN-12293 go.json http://purl.obolibrary.org/obo/GO_0102234 GO:0102233 biolink:MolecularActivity crotonaldehyde redutase activity Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ = butanal + NADP. MetaCyc:RXN-12292 go.json http://purl.obolibrary.org/obo/GO_0102233 GO:0102236 biolink:MolecularActivity trans-4-hexen-3-one reductase activity Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ = hexan-3-one + NADP. MetaCyc:RXN-12296 go.json http://purl.obolibrary.org/obo/GO_0102236 GO:0102235 biolink:MolecularActivity 1-penten-3-one reductase activity Catalysis of the reaction: 1-penten-3-one + NADPH + H+ = 1-pentan-3-one + NADP. MetaCyc:RXN-12295 go.json http://purl.obolibrary.org/obo/GO_0102235 GO:0102238 biolink:MolecularActivity geraniol kinase activity (ATP-dependent) activity Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+. MetaCyc:RXN-12307 go.json http://purl.obolibrary.org/obo/GO_0102238 GO:0102237 biolink:MolecularActivity ATP:farnesol kinase activity Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+. MetaCyc:RXN-12304|RHEA:61656 go.json ATP-dependent farnesol kinase activity http://purl.obolibrary.org/obo/GO_0102237 GO:0102241 biolink:MolecularActivity soyasaponin III rhamnosyltransferase activity Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III = H+ + UDP + soyasaponin I. EC:2.4.1.273|MetaCyc:RXN-12320|RHEA:31491 go.json http://purl.obolibrary.org/obo/GO_0102241 GO:0102240 biolink:MolecularActivity soyasapogenol B glucuronide galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate = H+ + UDP + soyasaponin III. EC:2.4.1.272|MetaCyc:RXN-12319|RHEA:31487 go.json http://purl.obolibrary.org/obo/GO_0102240 GO:0102243 biolink:MolecularActivity ATP:geranylgeraniol phosphotransferase activity Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP. EC:2.7.1.216|MetaCyc:RXN-12325|RHEA:61660 go.json http://purl.obolibrary.org/obo/GO_0102243 GO:0102245 biolink:MolecularActivity lupan-3beta,20-diol synthase activity Catalysis of the reaction: lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O. EC:4.2.1.128|MetaCyc:RXN-12338|RHEA:31351 go.json http://purl.obolibrary.org/obo/GO_0102245 GO:0102244 biolink:MolecularActivity 3-aminopropanal dehydrogenase activity Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O = 2 H+ + beta-alanine + NADH. MetaCyc:RXN-12332 go.json http://purl.obolibrary.org/obo/GO_0102244 GO:0102247 biolink:MolecularActivity malonyl-malonyl acyl carrier protein-condensing enzyme activity Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] = 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]. MetaCyc:RXN-12361 go.json http://purl.obolibrary.org/obo/GO_0102247 GO:0102246 biolink:MolecularActivity 6-amino-6-deoxyfutalosine hydrolase activity Catalysis of the reaction: aminodeoxyfutalosinate + H2O = dehypoxanthine futalosine + adenine. EC:3.2.2.30|MetaCyc:RXN-12346|RHEA:33079 go.json http://purl.obolibrary.org/obo/GO_0102246 GO:0102249 biolink:MolecularActivity phosphatidylcholine:diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine. MetaCyc:RXN-12386 go.json http://purl.obolibrary.org/obo/GO_0102249 GO:0102248 biolink:MolecularActivity diacylglycerol transacylase activity Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride. MetaCyc:RXN-12383 go.json http://purl.obolibrary.org/obo/GO_0102248 GO:0102250 biolink:MolecularActivity linear malto-oligosaccharide phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide. EC:2.4.1.1|MetaCyc:RXN-12392 go.json http://purl.obolibrary.org/obo/GO_0102250 GO:0102252 biolink:MolecularActivity cellulose 1,4-beta-cellobiosidase activity (reducing end) Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains. EC:3.2.1.176|MetaCyc:RXN-12420 go.json http://purl.obolibrary.org/obo/GO_0102252 GO:0102251 biolink:MolecularActivity all-trans-beta-apo-10'-carotenal cleavage oxygenase activity Catalysis of the reaction: 10'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial. EC:1.13.11.70|MetaCyc:RXN-12393|RHEA:26401 go.json http://purl.obolibrary.org/obo/GO_0102251 GO:0102254 biolink:MolecularActivity neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity Catalysis of the reaction: neoagarotetraose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agarotriose. EC:3.2.1.159|MetaCyc:RXN-12427 go.json http://purl.obolibrary.org/obo/GO_0102254 GO:0102253 biolink:MolecularActivity neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity Catalysis of the reaction: neoagarobiose + H2O = 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside. EC:3.2.1.159|MetaCyc:RXN-12426 go.json http://purl.obolibrary.org/obo/GO_0102253 GO:0102256 biolink:MolecularActivity neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity Catalysis of the reaction: neoagarohexaose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agaropentaose. EC:3.2.1.159|MetaCyc:RXN-12429 go.json http://purl.obolibrary.org/obo/GO_0102256 GO:0102255 biolink:MolecularActivity neo-lambda-carrahexaose hydrolase activity Catalysis of the reaction: neo-lambda-carrahexaose + H2O = neo-lambda-carratetraose + neo-lambda-carrabiose. EC:3.2.1.162|MetaCyc:RXN-12428 go.json http://purl.obolibrary.org/obo/GO_0102255 GO:0102258 biolink:MolecularActivity 1,3-diacylglycerol acylhydrolase activity Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid. MetaCyc:RXN-12433 go.json http://purl.obolibrary.org/obo/GO_0102258 GO:0102257 biolink:MolecularActivity 1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O = 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+. MetaCyc:RXN-12430 go.json http://purl.obolibrary.org/obo/GO_0102257 GO:0102259 biolink:MolecularActivity 1,2-diacylglycerol acylhydrolase activity Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid. MetaCyc:RXN-12434 go.json http://purl.obolibrary.org/obo/GO_0102259 GO:0102261 biolink:MolecularActivity 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity Catalysis of the reaction: NADP + a reduced coenzyme F420 = NADPH + H+ + an oxidized coenzyme F420. EC:1.5.1.40|MetaCyc:RXN-12450|RHEA:31363 go.json http://purl.obolibrary.org/obo/GO_0102261 GO:0102260 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102260 GO:0102263 biolink:MolecularActivity tRNA-dihydrouridine17 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) = H+ + a uracil17 in tRNA + NAD(P)H. EC:1.3.1.88|MetaCyc:RXN-12455 go.json http://purl.obolibrary.org/obo/GO_0102263 GO:0102262 biolink:MolecularActivity tRNA-dihydrouridine16 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H. EC:1.3.1.88|MetaCyc:RXN-12454 go.json http://purl.obolibrary.org/obo/GO_0102262 GO:0102265 biolink:MolecularActivity tRNA-dihydrouridine47 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H. EC:1.3.1.89|MetaCyc:RXN-12457 go.json http://purl.obolibrary.org/obo/GO_0102265 GO:0102264 biolink:MolecularActivity tRNA-dihydrouridine20 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) = H+ + a uracil20 in tRNA + NAD(P)H. EC:1.3.1.91|MetaCyc:RXN-12456 go.json http://purl.obolibrary.org/obo/GO_0102264 GO:0102267 biolink:MolecularActivity tRNA-dihydrouridine20b synthase activity Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H. EC:1.3.1.90|MetaCyc:RXN-12476 go.json http://purl.obolibrary.org/obo/GO_0102267 GO:0102266 biolink:MolecularActivity tRNA-dihydrouridine20a synthase activity Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H. EC:1.3.1.90|MetaCyc:RXN-12475 go.json http://purl.obolibrary.org/obo/GO_0102266 GO:0102201 biolink:MolecularActivity (+)-2-epi-prezizaene synthase activity Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphoric acid. MetaCyc:RXN-12117 go.json http://purl.obolibrary.org/obo/GO_0102201 GO:0043300 biolink:BiologicalProcess regulation of leukocyte degranulation Any process that modulates the frequency, rate, or extent of leukocyte degranulation. go.json regulation of immune cell degranulation|regulation of immune cell granule exocytosis|regulation of leucocyte degranulation|regulation of leukocyte granule exocytosis http://purl.obolibrary.org/obo/GO_0043300 GO:0102200 biolink:MolecularActivity N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate. EC:3.1.4.54|MetaCyc:RXN-12116|RHEA:33159 go.json http://purl.obolibrary.org/obo/GO_0102200 GO:0102203 biolink:MolecularActivity brassicasterol glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol = UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+. EC:2.4.1.173|MetaCyc:RXN-12125|RHEA:61840 go.json http://purl.obolibrary.org/obo/GO_0102203 GO:0043302 biolink:BiologicalProcess positive regulation of leukocyte degranulation Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. go.json activation of leukocyte degranulation|positive regulation of immune cell degranulation|positive regulation of leucocyte degranulation|stimulation of leukocyte degranulation|up regulation of leukocyte degranulation|up-regulation of leukocyte degranulation|upregulation of leukocyte degranulation http://purl.obolibrary.org/obo/GO_0043302 GO:0043301 biolink:BiologicalProcess negative regulation of leukocyte degranulation Any process that stops, prevents, or reduces the rate of leukocyte degranulation. go.json down regulation of leukocyte degranulation|down-regulation of leukocyte degranulation|downregulation of leukocyte degranulation|inhibition of leukocyte degranulation|negative regulation of immune cell degranulation|negative regulation of leucocyte degranulation http://purl.obolibrary.org/obo/GO_0043301 GO:0102202 biolink:MolecularActivity soladodine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + solasodine = UDP + solasodine 3-O-beta-D-glucopyranoside + H+. EC:2.4.1.173|MetaCyc:RXN-12123|RHEA:61844 go.json http://purl.obolibrary.org/obo/GO_0102202 GO:0102205 biolink:MolecularActivity cholesterol alpha-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+. EC:2.4.1.173|MetaCyc:RXN-12127|RHEA:61848 go.json cholesterol UDP-glucosyltransferase activity|cholesterol allpha-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0102205 GO:0102207 biolink:MolecularActivity obsolete docosanoate omega-hydroxylase activity OBSOLETE. Catalysis of the reaction: docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. go.json behenate omega-hydroxylase activity True http://purl.obolibrary.org/obo/GO_0102207 GO:0043308 biolink:BiologicalProcess eosinophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil. go.json eosinophil granule exocytosis http://purl.obolibrary.org/obo/GO_0043308 GO:0102209 biolink:MolecularActivity trans-permethrin hydrolase activity Catalysis of the reaction: (-)-trans-permethrin + H2O = H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. EC:3.1.1.88|MetaCyc:RXN-12167|RHEA:30283 go.json http://purl.obolibrary.org/obo/GO_0102209 GO:0102208 biolink:MolecularActivity 2-polyprenyl-6-hydroxyphenol methylase activity Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol. MetaCyc:RXN-12160|RHEA:31411 go.json http://purl.obolibrary.org/obo/GO_0102208 GO:0043307 biolink:BiologicalProcess eosinophil activation The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0043307 GO:0043309 biolink:BiologicalProcess regulation of eosinophil degranulation Any process that modulates the frequency, rate, or extent of eosinophil degranulation. go.json regulation of eosinophil granule exocytosis http://purl.obolibrary.org/obo/GO_0043309 GO:0043304 biolink:BiologicalProcess regulation of mast cell degranulation Any process that modulates the frequency, rate, or extent of mast cell degranulation. go.json regulation of mast cell granule exocytosis http://purl.obolibrary.org/obo/GO_0043304 GO:0043303 biolink:BiologicalProcess mast cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. go.json mast cell granule exocytosis http://purl.obolibrary.org/obo/GO_0043303 GO:0043306 biolink:BiologicalProcess positive regulation of mast cell degranulation Any process that activates or increases the frequency, rate or extent of mast cell degranulation. go.json activation of mast cell degranulation|positive regulation of mast cell granule exocytosis|stimulation of mast cell degranulation|up regulation of mast cell degranulation|up-regulation of mast cell degranulation|upregulation of mast cell degranulation http://purl.obolibrary.org/obo/GO_0043306 GO:0043305 biolink:BiologicalProcess negative regulation of mast cell degranulation Any process that stops, prevents, or reduces the rate of mast cell degranulation. go.json down regulation of mast cell degranulation|down-regulation of mast cell degranulation|downregulation of mast cell degranulation|inhibition of mast cell degranulation|negative regulation of mast cell granule exocytosis http://purl.obolibrary.org/obo/GO_0043305 GO:0018391 biolink:BiologicalProcess obsolete C-terminal peptidyl-glutamic acid tyrosinylation OBSOLETE. The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein. go.json True http://purl.obolibrary.org/obo/GO_0018391 GO:0018390 biolink:BiologicalProcess obsolete peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine OBSOLETE. The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester. go.json peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine|peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine|peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine True http://purl.obolibrary.org/obo/GO_0018390 GO:0018393 biolink:BiologicalProcess internal peptidyl-lysine acetylation The addition of an acetyl group to a non-terminal lysine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0018393 gocheck_do_not_annotate GO:0018392 biolink:MolecularActivity glycoprotein 3-alpha-L-fucosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H+. EC:2.4.1.214|KEGG_REACTION:R06015|MetaCyc:2.4.1.214-RXN|RHEA:24444 go.json GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity|GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity|GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity|GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity|GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity|GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity|GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity|GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0018392 GO:0102210 biolink:MolecularActivity rhamnogalacturonan endolyase activity Catalysis of the reaction: H2O + a rhamnogalacturonan type I = [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]. EC:4.2.2.23|MetaCyc:RXN-12173 go.json http://purl.obolibrary.org/obo/GO_0102210 GO:0043311 biolink:BiologicalProcess positive regulation of eosinophil degranulation Any process that activates or increases the frequency, rate or extent of eosinophil degranulation. go.json activation of eosinophil degranulation|positive regulation of eosinophil granule exocytosis|stimulation of eosinophil degranulation|up regulation of eosinophil degranulation|up-regulation of eosinophil degranulation|upregulation of eosinophil degranulation http://purl.obolibrary.org/obo/GO_0043311 GO:0102212 biolink:MolecularActivity unsaturated chondroitin disaccharide hydrolase activity Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate. EC:3.2.1.180|MetaCyc:RXN-12177|RHEA:31647 go.json http://purl.obolibrary.org/obo/GO_0102212 GO:0102211 biolink:MolecularActivity unsaturated rhamnogalacturonyl hydrolase activity Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose. EC:3.2.1.172|MetaCyc:RXN-12174|RHEA:30927 go.json http://purl.obolibrary.org/obo/GO_0102211 GO:0043310 biolink:BiologicalProcess negative regulation of eosinophil degranulation Any process that stops, prevents, or reduces the rate of eosinophil degranulation. go.json down regulation of eosinophil degranulation|down-regulation of eosinophil degranulation|downregulation of eosinophil degranulation|inhibition of eosinophil degranulation|negative regulation of eosinophil granule exocytosis http://purl.obolibrary.org/obo/GO_0043310 GO:0102214 biolink:MolecularActivity omega-hydroxy fatty acyl-CoA synthetase activity Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA. MetaCyc:RXN-12185 go.json http://purl.obolibrary.org/obo/GO_0102214 GO:0043313 biolink:BiologicalProcess regulation of neutrophil degranulation Any process that modulates the frequency, rate, or extent of neutrophil degranulation. go.json regulation of neutrophil granule exocytosis http://purl.obolibrary.org/obo/GO_0043313 GO:0043312 biolink:BiologicalProcess neutrophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil. go.json heterophil degranulation|neutrophil granule exocytosis http://purl.obolibrary.org/obo/GO_0043312 GO:0102213 biolink:MolecularActivity in-chain hydroxy fatty acyl-CoA synthetase activity Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA. MetaCyc:RXN-12184 go.json http://purl.obolibrary.org/obo/GO_0102213 GO:0102216 biolink:MolecularActivity maltodextrin water dikinase Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin. EC:2.7.9.4|MetaCyc:RXN-12201 go.json http://purl.obolibrary.org/obo/GO_0102216 GO:0102215 biolink:MolecularActivity thiocyanate methyltransferase activity Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine = methyl thiocyanate + S-adenosyl-L-homocysteine. MetaCyc:RXN-12189|RHEA:28014 go.json http://purl.obolibrary.org/obo/GO_0102215 GO:0102218 biolink:MolecularActivity starch, H2O dikinase activity Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin. EC:2.7.9.4|MetaCyc:RXN-12203 go.json http://purl.obolibrary.org/obo/GO_0102218 GO:0102217 biolink:MolecularActivity 6-phosphoglucan, water dikinase activity Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin. EC:2.7.9.5|MetaCyc:RXN-12202|RHEA:10256 go.json http://purl.obolibrary.org/obo/GO_0102217 GO:0043319 biolink:BiologicalProcess positive regulation of cytotoxic T cell degranulation Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation. go.json activation of cytotoxic T cell degranulation|positive regulation of cytotoxic T cell granule exocytosis|positive regulation of cytotoxic T lymphocyte degranulation|positive regulation of cytotoxic T lymphocyte granule exocytosis|positive regulation of cytotoxic T-cell degranulation|positive regulation of cytotoxic T-cell granule exocytosis|positive regulation of cytotoxic T-lymphocyte degranulation|positive regulation of cytotoxic T-lymphocyte granule exocytosis|stimulation of cytotoxic T cell degranulation|up regulation of cytotoxic T cell degranulation|up-regulation of cytotoxic T cell degranulation|upregulation of cytotoxic T cell degranulation http://purl.obolibrary.org/obo/GO_0043319 GO:0102219 biolink:MolecularActivity phosphogluco-amylopectin water dikinase activity Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin. EC:2.7.9.5|MetaCyc:RXN-12204 go.json http://purl.obolibrary.org/obo/GO_0102219 GO:0043318 biolink:BiologicalProcess negative regulation of cytotoxic T cell degranulation Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. go.json down regulation of cytotoxic T cell degranulation|down-regulation of cytotoxic T cell degranulation|downregulation of cytotoxic T cell degranulation|inhibition of cytotoxic T cell degranulation|negative regulation of cytotoxic T cell granule exocytosis|negative regulation of cytotoxic T lymphocyte degranulation|negative regulation of cytotoxic T lymphocyte granule exocytosis|negative regulation of cytotoxic T-cell degranulation|negative regulation of cytotoxic T-cell granule exocytosis|negative regulation of cytotoxic T-lymphocyte degranulation|negative regulation of cytotoxic T-lymphocyte granule exocytosis http://purl.obolibrary.org/obo/GO_0043318 GO:0043315 biolink:BiologicalProcess positive regulation of neutrophil degranulation Any process that activates or increases the frequency, rate or extent of neutrophil degranulation. go.json activation of neutrophil degranulation|positive regulation of neutrophil granule exocytosis|stimulation of neutrophil degranulation|up regulation of neutrophil degranulation|up-regulation of neutrophil degranulation|upregulation of neutrophil degranulation http://purl.obolibrary.org/obo/GO_0043315 GO:0043314 biolink:BiologicalProcess negative regulation of neutrophil degranulation Any process that stops, prevents, or reduces the rate of neutrophil degranulation. go.json down regulation of neutrophil degranulation|down-regulation of neutrophil degranulation|downregulation of neutrophil degranulation|inhibition of neutrophil degranulation|negative regulation of neutrophil granule exocytosis http://purl.obolibrary.org/obo/GO_0043314 GO:0043317 biolink:BiologicalProcess regulation of cytotoxic T cell degranulation Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. go.json regulation of cytotoxic T cell granule exocytosis|regulation of cytotoxic T lymphocyte degranulation|regulation of cytotoxic T lymphocyte granule exocytosis|regulation of cytotoxic T-cell degranulation|regulation of cytotoxic T-cell granule exocytosis|regulation of cytotoxic T-lymphocyte degranulation|regulation of cytotoxic T-lymphocyte granule exocytosis http://purl.obolibrary.org/obo/GO_0043317 GO:0043316 biolink:BiologicalProcess cytotoxic T cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. go.json cytotoxic T cell granule exocytosis|cytotoxic T lymphocyte degranulation|cytotoxic T lymphocyte granule exocytosis|cytotoxic T-cell degranulation|cytotoxic T-cell granule exocytosis|cytotoxic T-lymphocyte degranulation|cytotoxic T-lymphocyte granule exocytosis http://purl.obolibrary.org/obo/GO_0043316 GO:0018388 biolink:BiologicalProcess N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine. RESID:AA0275 go.json http://purl.obolibrary.org/obo/GO_0018388 gocheck_do_not_annotate GO:0018387 biolink:BiologicalProcess N-terminal peptidyl-amino acid deamination to pyruvic acid The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. RESID:AA0127 go.json http://purl.obolibrary.org/obo/GO_0018387 gocheck_do_not_annotate GO:0018389 biolink:BiologicalProcess N-terminal peptidyl-valine deamination The deamination of the N-terminal valine residue of a protein to form isobutyrate. go.json http://purl.obolibrary.org/obo/GO_0018389 gocheck_do_not_annotate GO:0018384 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018384 GO:0018383 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018383 GO:0018386 biolink:BiologicalProcess N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine. RESID:AA0274 go.json http://purl.obolibrary.org/obo/GO_0018386 gocheck_do_not_annotate GO:0018385 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018385 GO:0102220 biolink:MolecularActivity hydrogenase activity (NAD+, ferredoxin) Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin. EC:1.12.1.4|MetaCyc:RXN-12215|RHEA:30279 go.json http://purl.obolibrary.org/obo/GO_0102220 GO:0102223 biolink:MolecularActivity 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 4 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene, 4,4'-diapo-zeta-carotene and 4,4'-diapolycopene as intermediates, and 4,4'-diapolycopene as the end product. EC:1.3.8.2|MetaCyc:RXN-12224|MetaCyc:RXN-12258|RHEA:31391|RHEA:42800 go.json 4,4'-diapo-zeta-carotene desaturase activity|4,4'-diaponeurosporene desaturase activity|4,4'-diapophytoene desaturase activity|4,4'-diapophytofluene desaturase activity http://purl.obolibrary.org/obo/GO_0102223 GO:0043322 biolink:BiologicalProcess negative regulation of natural killer cell degranulation Any process that stops, prevents, or reduces the rate of natural killer cell degranulation. go.json down regulation of natural killer cell degranulation|down-regulation of natural killer cell degranulation|downregulation of natural killer cell degranulation|inhibition of natural killer cell degranulation|negative regulation of NK cell degranulation|negative regulation of NK cell granule exocytosis|negative regulation of natural killer cell granule exocytosis http://purl.obolibrary.org/obo/GO_0043322 GO:0043321 biolink:BiologicalProcess regulation of natural killer cell degranulation Any process that modulates the frequency, rate, or extent of natural killer cell degranulation. go.json regulation of NK cell degranulation|regulation of NK cell granule exocytosis|regulation of natural killer cell granule exocytosis http://purl.obolibrary.org/obo/GO_0043321 GO:0102222 biolink:MolecularActivity obsolete 6-phosophogluco-3-phosphogluco-starch phosphatase activity OBSOLETE. Catalysis of the reaction: m+q H2O + a 6-phosphogluco-3-phosphogluco-amylopectin = m+q hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin. MetaCyc:RXN-12218 go.json True http://purl.obolibrary.org/obo/GO_0102222 GO:0043324 biolink:BiologicalProcess pigment metabolic process involved in developmental pigmentation The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism. go.json pigment metabolic process during developmental pigmentation|pigment metabolism during developmental pigmentation http://purl.obolibrary.org/obo/GO_0043324 GO:0102225 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102225 GO:0102224 biolink:MolecularActivity GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+. MetaCyc:RXN-12236|RHEA:46316 go.json http://purl.obolibrary.org/obo/GO_0102224 GO:0043323 biolink:BiologicalProcess positive regulation of natural killer cell degranulation Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation. go.json activation of natural killer cell degranulation|positive regulation of NK cell degranulation|positive regulation of NK cell granule exocytosis|positive regulation of natural killer cell granule exocytosis|stimulation of natural killer cell degranulation|up regulation of natural killer cell degranulation|up-regulation of natural killer cell degranulation|upregulation of natural killer cell degranulation http://purl.obolibrary.org/obo/GO_0043323 GO:0043320 biolink:BiologicalProcess natural killer cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell. go.json NK cell degranulation|NK cell granule exocytosis|natural killer cell granule exocytosis http://purl.obolibrary.org/obo/GO_0043320 GO:0102229 biolink:MolecularActivity amylopectin maltohydrolase activity Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin = amylopectin + maltose. EC:3.2.1.2|MetaCyc:RXN-12278 go.json http://purl.obolibrary.org/obo/GO_0102229 GO:0043329 biolink:BiologicalProcess obsolete protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway OBSOLETE. The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway. go.json protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway|protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway|protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway|protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway|protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway|protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway|protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway|protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway|protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway True http://purl.obolibrary.org/obo/GO_0043329 GO:0043326 biolink:BiologicalProcess chemotaxis to folate The directed movement of a motile cell or organism in response to the presence of folate. go.json http://purl.obolibrary.org/obo/GO_0043326 GO:0043325 biolink:MolecularActivity phosphatidylinositol-3,4-bisphosphate binding Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. go.json http://purl.obolibrary.org/obo/GO_0043325 GO:0043328 biolink:BiologicalProcess protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. go.json protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway|protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway|protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway|protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway|protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway|protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway|protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway|protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway|protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway http://purl.obolibrary.org/obo/GO_0043328 GO:0043327 biolink:BiologicalProcess chemotaxis to cAMP The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP. go.json chemotaxis to 3',5' cAMP|chemotaxis to 3',5'-cAMP|chemotaxis to adenosine 3',5'-cyclophosphate|chemotaxis to cyclic AMP http://purl.obolibrary.org/obo/GO_0043327 GO:0018399 biolink:BiologicalProcess obsolete peptidyl-phenylalanine bromination to L-4'-bromophenylalanine OBSOLETE. The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine. RESID:AA0176 go.json True http://purl.obolibrary.org/obo/GO_0018399 GO:0018398 biolink:BiologicalProcess obsolete peptidyl-phenylalanine bromination to L-3'-bromophenylalanine OBSOLETE. The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine. RESID:AA0175 go.json True http://purl.obolibrary.org/obo/GO_0018398 GO:0018395 biolink:BiologicalProcess peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine. RESID:AA0028 go.json http://purl.obolibrary.org/obo/GO_0018395 gocheck_do_not_annotate GO:0018394 biolink:BiologicalProcess peptidyl-lysine acetylation The acetylation of peptidyl-lysine. go.json http://purl.obolibrary.org/obo/GO_0018394 gocheck_do_not_annotate GO:0018397 biolink:BiologicalProcess obsolete peptidyl-phenylalanine bromination to L-2'-bromophenylalanine OBSOLETE. The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine. RESID:AA0174 go.json True http://purl.obolibrary.org/obo/GO_0018397 GO:0018396 biolink:BiologicalProcess peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine. RESID:AA0235 go.json http://purl.obolibrary.org/obo/GO_0018396 gocheck_do_not_annotate GO:0102272 biolink:MolecularActivity homophytochelatin synthase activity (polymer-forming) Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine. MetaCyc:RXN-12528 go.json http://purl.obolibrary.org/obo/GO_0102272 GO:0102274 biolink:MolecularActivity glutathione S-conjugate carboxypeptidase activity Catalysis of the reaction: H2O + a glutathione-toxin conjugate = glycine + a [Glu-Cys]-S-conjugate. MetaCyc:RXN-12532 go.json http://purl.obolibrary.org/obo/GO_0102274 GO:0102273 biolink:MolecularActivity homophytochelatin synthase (dimmer forming) activity Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate = gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine. MetaCyc:RXN-12529 go.json http://purl.obolibrary.org/obo/GO_0102273 GO:0102276 biolink:MolecularActivity 2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ = ethene + 3 carbon dioxide + H2O. EC:1.13.12.19|MetaCyc:RXN-12538|RHEA:31523 go.json http://purl.obolibrary.org/obo/GO_0102276 GO:0102275 biolink:MolecularActivity cysteine-S-conjugate N-malonyl transferase activity Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate = coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate. MetaCyc:RXN-12534 go.json http://purl.obolibrary.org/obo/GO_0102275 GO:0102278 biolink:MolecularActivity N,N'-diacetylchitobiose synthase activity Catalysis of the reaction: n H2O + chitin = N,N'-diacetylchitobiose. MetaCyc:RXN-12554 go.json http://purl.obolibrary.org/obo/GO_0102278 GO:0102277 biolink:MolecularActivity 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine. MetaCyc:RXN-12544 go.json http://purl.obolibrary.org/obo/GO_0102277 GO:0102279 biolink:MolecularActivity lecithin:11-cis retinol acyltransferase activity Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine = a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine. EC:2.3.1.135|MetaCyc:RXN-12563 go.json http://purl.obolibrary.org/obo/GO_0102279 GO:0102281 biolink:MolecularActivity formylaminopyrimidine deformylase activity Catalysis of the reaction: formylaminopyrimidine + H2O = 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate. MetaCyc:RXN-12612 go.json http://purl.obolibrary.org/obo/GO_0102281 GO:0102280 biolink:MolecularActivity choline monooxygenase activity (NADP-dependent) Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+. MetaCyc:RXN-12582 go.json http://purl.obolibrary.org/obo/GO_0102280 GO:0102283 biolink:MolecularActivity obsolete 3-ketodihydrosphinganine (C20) reductase activity OBSOLETE. Catalysis of the reaction: C20 sphinganine(1+) + NADP = C20 3-dehydrosphinganine(1+) + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102283 GO:0102282 biolink:MolecularActivity obsolete 3-ketodihydrosphinganine (C18) reductase activity OBSOLETE. Catalysis of the reaction: NAD(1-) + a sphinganine = 3-dehydrosphinganinium(1+) + NADH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102282 GO:0102285 biolink:MolecularActivity 1-deoxy-11-oxopentalenate oxygenase activity Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP. EC:1.14.13.170|MetaCyc:RXN-12654|RHEA:34635 go.json http://purl.obolibrary.org/obo/GO_0102285 GO:0102284 biolink:MolecularActivity obsolete L-threo-sphinganine reductase activity OBSOLETE. Catalysis of the reaction: L-threo-sphinganine + NADP = H+ + NADPH + 3-dehydrosphinganinium(1+). go.json True http://purl.obolibrary.org/obo/GO_0102284 GO:0102287 biolink:MolecularActivity 4-coumaroylhexanoylmethane synthase activity Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O = 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide. MetaCyc:RXN-12668 go.json http://purl.obolibrary.org/obo/GO_0102287 GO:0102286 biolink:MolecularActivity ornithine N-delta-acetyltransferase activity Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine. MetaCyc:RXN-12667 go.json http://purl.obolibrary.org/obo/GO_0102286 GO:0102289 biolink:MolecularActivity beta-amyrin 11-oxidase activity Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ = 11-oxo-beta-amyrin + 3 H2O + 2 NADP. EC:1.14.14.152|MetaCyc:RXN-12680|RHEA:31711 go.json http://purl.obolibrary.org/obo/GO_0102289 GO:0102290 biolink:MolecularActivity beta-amyrin monooxygenase activity Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ = 11alpha-hydroxy-beta-amyrin + H2O + NADP. EC:1.14.14.152|MetaCyc:RXN-12681|RHEA:31715 go.json http://purl.obolibrary.org/obo/GO_0102290 GO:0102292 biolink:MolecularActivity 30-hydroxy-beta-amyrin 11-hydroxylase activity Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP. MetaCyc:RXN-12683 go.json http://purl.obolibrary.org/obo/GO_0102292 GO:0102291 biolink:MolecularActivity 11alpha-hydroxy-beta-amyrin dehydrogenase activity Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP. EC:1.14.14.152|MetaCyc:RXN-12682|RHEA:31719 go.json http://purl.obolibrary.org/obo/GO_0102291 GO:0102294 biolink:MolecularActivity cholesterol dehydrogenase activity Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+. EC:1.1.1.145|MetaCyc:RXN-12693|RHEA:35459 go.json http://purl.obolibrary.org/obo/GO_0102294 GO:0102293 biolink:MolecularActivity pheophytinase b activity Catalysis of the reaction: pheophytin b + H2O = H+ + pheophorbide b + phytol. EC:3.1.1.14|MetaCyc:RXN-12686 go.json http://purl.obolibrary.org/obo/GO_0102293 GO:0102296 biolink:MolecularActivity 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+. EC:3.7.1.17|MetaCyc:RXN-12718|RHEA:32035 go.json http://purl.obolibrary.org/obo/GO_0102296 GO:0102295 biolink:MolecularActivity 4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA = 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A. MetaCyc:RXN-12699 go.json http://purl.obolibrary.org/obo/GO_0102295 GO:0102298 biolink:MolecularActivity selenocystathione synthase activity Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine. MetaCyc:RXN-12728 go.json http://purl.obolibrary.org/obo/GO_0102298 GO:0102297 biolink:MolecularActivity selenate adenylyltransferase activity Catalysis of the reaction: selenic acid + ATP + 2 H+ = adenylyl selenate + diphosphoric acid. MetaCyc:RXN-12720 go.json http://purl.obolibrary.org/obo/GO_0102297 GO:0102299 biolink:MolecularActivity linolenate 9R-lipoxygenase activity Catalysis of the reaction: alpha-linolenate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate. EC:1.13.11.61|MetaCyc:RXN-12759|RHEA:31687 go.json http://purl.obolibrary.org/obo/GO_0102299 GO:0033927 biolink:MolecularActivity glucan 1,4-alpha-maltohexaosidase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends. EC:3.2.1.98|MetaCyc:3.2.1.98-RXN go.json 1,4-alpha-D-glucan maltohexaohydrolase activity|G6-amylase activity|exo-maltohexaohydrolase activity|maltohexaose-producing amylase activity http://purl.obolibrary.org/obo/GO_0033927 GO:0043292 biolink:CellularComponent contractile fiber Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. go.json contractile fibre http://purl.obolibrary.org/obo/GO_0043292 GO:0033926 biolink:MolecularActivity glycopeptide alpha-N-acetylgalactosaminidase activity Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins. EC:3.2.1.97|MetaCyc:3.2.1.97-RXN go.json D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity|endo-alpha-N-acetylgalactosaminidase activity|endo-alpha-acetylgalactosaminidase activity http://purl.obolibrary.org/obo/GO_0033926 GO:0043291 biolink:CellularComponent RAVE complex A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme. go.json regulator of the (H+)-ATPase of the vacuolar and endosomal membranes http://purl.obolibrary.org/obo/GO_0043291 GO:0033925 biolink:MolecularActivity mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. EC:3.2.1.96|MetaCyc:3.2.1.96-RXN|Reactome:R-HSA-8853379 go.json N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity|di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity|endo-N-acetyl-beta-D-glucosaminidase activity|endo-N-acetyl-beta-glucosaminidase activity|endo-beta-(1->4)-N-acetylglucosaminidase activity|endo-beta-N-acetylglucosaminidase D activity|endo-beta-N-acetylglucosaminidase F activity|endo-beta-N-acetylglucosaminidase H activity|endo-beta-N-acetylglucosaminidase L activity|endo-beta-N-acetylglucosaminidase activity|endo-beta-acetylglucosaminidase activity|endoglycosidase H activity|endoglycosidase S activity|glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity|glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity|mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity|mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity http://purl.obolibrary.org/obo/GO_0033925 GO:0043294 biolink:CellularComponent mitochondrial glutamate synthase complex (NADH) A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. go.json http://purl.obolibrary.org/obo/GO_0043294 GO:0008969 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008969 GO:0043293 biolink:CellularComponent apoptosome A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms. Wikipedia:Apoptosome go.json http://purl.obolibrary.org/obo/GO_0043293 GO:0033924 biolink:MolecularActivity dextran 1,6-alpha-isomaltotriosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains. EC:3.2.1.95|MetaCyc:3.2.1.95-RXN go.json 1,6-alpha-D-glucan isomaltotriohydrolase activity|exo-isomaltotriohydrolase activity http://purl.obolibrary.org/obo/GO_0033924 GO:0008968 biolink:MolecularActivity D-sedoheptulose 7-phosphate isomerase activity Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. MetaCyc:RXN0-4301|RHEA:27489 go.json phosphoheptose isomerase activity http://purl.obolibrary.org/obo/GO_0008968 GO:0033923 biolink:MolecularActivity glucan 1,6-alpha-isomaltosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains. EC:3.2.1.94|MetaCyc:3.2.1.94-RXN go.json 1,6-alpha-D-glucan isomaltohydrolase activity|G2-dextranase activity|exo-isomaltohydrolase activity|isomalto-dextranase activity|isomaltodextranase activity http://purl.obolibrary.org/obo/GO_0033923 GO:0008967 biolink:MolecularActivity phosphoglycolate phosphatase activity Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. EC:3.1.3.18|KEGG_REACTION:R01334|MetaCyc:GPH-RXN|RHEA:14369 go.json 2-phosphoglycolate phosphatase activity|2-phosphoglycolate phosphohydrolase activity|P-glycolate phosphatase activity|phosphoglycolate hydrolase activity|phosphoglycollate phosphatase activity http://purl.obolibrary.org/obo/GO_0008967 GO:0033922 biolink:MolecularActivity peptidoglycan beta-N-acetylmuramidase activity Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues. EC:3.2.1.92|MetaCyc:3.2.1.92-RXN go.json beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity|exo-beta-N-acetylmuramidase activity|exo-beta-acetylmuramidase activity|peptidoglycan beta-N-acetylmuramoylexohydrolase activity http://purl.obolibrary.org/obo/GO_0033922 GO:0008966 biolink:MolecularActivity phosphoglucosamine mutase activity Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. EC:5.4.2.10|KEGG_REACTION:R02060|MetaCyc:5.4.2.10-RXN|RHEA:23424 go.json D-glucosamine 1,6-phosphomutase activity|alpha-D-glucosamine 1,6-phosphomutase activity http://purl.obolibrary.org/obo/GO_0008966 GO:0033921 biolink:MolecularActivity capsular-polysaccharide endo-1,3-alpha-galactosidase activity Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide. EC:3.2.1.87|MetaCyc:3.2.1.87-RXN go.json aerobacter-capsular-polysaccharide galactohydrolase activity|capsular polysaccharide galactohydrolase activity|polysaccharide depolymerase activity http://purl.obolibrary.org/obo/GO_0033921 GO:0008965 biolink:MolecularActivity phosphoenolpyruvate-protein phosphotransferase activity Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. EC:2.7.3.9|MetaCyc:2.7.3.9-RXN|RHEA:23880 go.json enzyme I of the phosphotransferase system|phosphoenolpyruvate sugar phosphotransferase enzyme I activity|phosphoenolpyruvate--protein phosphatase activity|phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity|phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity|phosphopyruvate--protein factor phosphotransferase activity|phosphopyruvate--protein phosphotransferase activity|sugar--PEP phosphotransferase enzyme I activity http://purl.obolibrary.org/obo/GO_0008965 GO:0043290 biolink:BiologicalProcess apocarotenoid catabolic process The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid. go.json apo carotenoid catabolic process|apocarotenoid breakdown|apocarotenoid catabolism|apocarotenoid degradation http://purl.obolibrary.org/obo/GO_0043290 GO:0008964 biolink:MolecularActivity phosphoenolpyruvate carboxylase activity Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-. EC:4.1.1.31|KEGG_REACTION:R00345|MetaCyc:PEPCARBOX-RXN|RHEA:28370 go.json PEP carboxylase activity|PEPC|PEPCase activity|phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)|phosphate:oxaloacetate carboxy-lyase (phosphorylating)|phosphoenolpyruvic carboxylase activity|phosphopyruvate (phosphate) carboxylase activity http://purl.obolibrary.org/obo/GO_0008964 GO:0033920 biolink:MolecularActivity 6-phospho-beta-galactosidase activity Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. EC:3.2.1.85|MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN|RHEA:24568 go.json 6-phospho-beta-D-galactosidase activity|6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity|beta-D-phosphogalactoside galactohydrolase activity|phospho-beta-D-galactosidase activity|phospho-beta-galactosidase activity http://purl.obolibrary.org/obo/GO_0033920 GO:0008963 biolink:MolecularActivity phospho-N-acetylmuramoyl-pentapeptide-transferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. EC:2.7.8.13|MetaCyc:RXN-8975|RHEA:21920 go.json MraY transferase activity|UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity|UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity|UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity|UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity|UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity|UDP-MurNAc-pentapeptide phosphotransferase activity|phospho-MurNAc-pentapeptide transferase activity|phospho-N-acetylmuramoyl pentapeptide translocase activity|phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity|phosphoacetylmuramoylpentapeptide translocase activity|phosphoacetylmuramoylpentapeptidetransferase activity http://purl.obolibrary.org/obo/GO_0008963 goslim_chembl GO:0043299 biolink:BiologicalProcess leukocyte degranulation The regulated exocytosis of secretory granules by a leukocyte. go.json immune cell degranulation|immune cell granule exocytosis|leucocyte degranulation|leukocyte granule exocytosis http://purl.obolibrary.org/obo/GO_0043299 GO:0008962 biolink:MolecularActivity phosphatidylglycerophosphatase activity Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. EC:3.1.3.27|MetaCyc:PGPPHOSPHA-RXN|RHEA:16725|Reactome:R-HSA-1483197 go.json PGP phosphatase activity|phosphatidylglycerol phosphatase activity|phosphatidylglycerol phosphate phosphatase activity|phosphatidylglycerophosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008962 GO:0008961 biolink:MolecularActivity phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein. EC:2.5.1.145|RHEA:56712 go.json http://purl.obolibrary.org/obo/GO_0008961 GO:0008960 biolink:MolecularActivity phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose. EC:2.7.8.20|MetaCyc:PGLYCEROLTRANSI-RXN go.json oligosaccharide glycerophosphotransferase activity|phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity|phosphoglycerol transferase I|phosphoglycerol transferase activity http://purl.obolibrary.org/obo/GO_0008960 GO:0043296 biolink:CellularComponent apical junction complex A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. go.json apical cell junction complex|apical junction http://purl.obolibrary.org/obo/GO_0043296 GO:0043295 biolink:MolecularActivity glutathione binding Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. go.json http://purl.obolibrary.org/obo/GO_0043295 GO:0033929 biolink:MolecularActivity blood-group-substance endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances. EC:3.2.1.102|MetaCyc:3.2.1.102-RXN go.json blood-group-substance 1,4-beta-D-galactanohydrolase activity|endo-beta-galactosidase activity http://purl.obolibrary.org/obo/GO_0033929 GO:0043298 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043298 GO:0033928 biolink:MolecularActivity mannan 1,4-mannobiosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends. EC:3.2.1.100|MetaCyc:3.2.1.100-RXN go.json 1,4-beta-D-mannan mannobiohydrolase activity|exo-1,4-beta-mannobiohydrolase activity|exo-beta-mannanase activity|mannan 1,4-beta-mannobiosidase activity http://purl.obolibrary.org/obo/GO_0033928 GO:0043297 biolink:BiologicalProcess apical junction assembly The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. go.json apical junction complex assembly http://purl.obolibrary.org/obo/GO_0043297 GO:0033916 biolink:MolecularActivity beta-agarase activity Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product. EC:3.2.1.81 go.json AgaA|AgaB|agarase activity|agarose 3-glycanohydrolase activity|agarose 4-glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0033916 GO:0033915 biolink:MolecularActivity mannan 1,2-(1,3)-alpha-mannosidase activity Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose. EC:3.2.1.77|MetaCyc:3.2.1.77-RXN go.json 1,2-1,3-alpha-D-mannan mannohydrolase activity|exo-1,2-1,3-alpha-mannosidase activity http://purl.obolibrary.org/obo/GO_0033915 GO:0033914 biolink:MolecularActivity xylan 1,3-beta-xylosidase activity Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans. EC:3.2.1.72|MetaCyc:3.2.1.72-RXN go.json 1,3-beta-D-xylan xylohydrolase activity|1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity|beta-1,3'-xylanase activity|exo-1,3-beta-xylosidase activity|exo-beta-1,3'-xylanase activity http://purl.obolibrary.org/obo/GO_0033914 GO:0033913 biolink:MolecularActivity glucan endo-1,2-beta-glucosidase activity Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans. EC:3.2.1.71|MetaCyc:3.2.1.71-RXN go.json 1,2-beta-D-glucan glucanohydrolase activity|beta-D-1,2-glucanase activity|endo-(1->2)-beta-D-glucanase activity|endo-1,2-beta-glucanase activity http://purl.obolibrary.org/obo/GO_0033913 GO:0008979 biolink:MolecularActivity prophage integrase activity Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. go.json integrase activity involved in establishment of integrated proviral latency http://purl.obolibrary.org/obo/GO_0008979 GO:0033912 biolink:MolecularActivity 2,6-beta-fructan 6-levanbiohydrolase activity Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain. EC:3.2.1.64|MetaCyc:3.2.1.64-RXN go.json 2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity|2,6-beta-D-fructan 6-levanbiohydrolase activity|2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity|beta-2,6-fructan-6-levanbiohydrolase activity|levanbiose-producing levanase activity http://purl.obolibrary.org/obo/GO_0033912 GO:0008978 biolink:MolecularActivity obsolete prepilin peptidase activity OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine. go.json prepilin peptidase activity True http://purl.obolibrary.org/obo/GO_0008978 GO:0033911 biolink:MolecularActivity mycodextranase activity Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds. EC:3.2.1.61|MetaCyc:3.2.1.61-RXN go.json 1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity http://purl.obolibrary.org/obo/GO_0033911 GO:0008977 biolink:MolecularActivity prephenate dehydrogenase (NAD+) activity Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH. EC:1.3.1.12|KEGG_REACTION:R01728|MetaCyc:PREPHENATEDEHYDROG-RXN|RHEA:13869 go.json chorismate mutase--prephenate dehydrogenase activity|hydroxyphenylpyruvate synthase activity|prephenate:NAD+ oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0008977 GO:0008976 biolink:MolecularActivity polyphosphate kinase activity Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). EC:2.7.4.1|MetaCyc:POLYPHOSPHATE-KINASE-RXN|RHEA:19573 go.json ATP-polyphosphate phosphotransferase activity|ATP:polyphosphate phosphotransferase activity|polyphosphate polymerase activity|polyphosphoric acid kinase activity http://purl.obolibrary.org/obo/GO_0008976 GO:0033910 biolink:MolecularActivity glucan 1,4-alpha-maltotetraohydrolase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends. EC:3.2.1.60|MetaCyc:3.2.1.60-RXN go.json 1,4-alpha-D-glucan maltotetraohydrolase activity|G4-amylase activity|exo-maltotetraohydrolase activity|glucan 1,4-alpha-maltotetrahydrolase activity|maltotetraose-forming amylase activity http://purl.obolibrary.org/obo/GO_0033910 GO:0008975 biolink:MolecularActivity obsolete pitrilysin activity OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon. go.json Escherichia coli metalloproteinase Pi|Escherichia coli protease III|PTR|pitrilysin activity|protease III activity|protease Pi activity|proteinase Pi True http://purl.obolibrary.org/obo/GO_0008975 GO:0008974 biolink:MolecularActivity phosphoribulokinase activity Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+. EC:2.7.1.19|KEGG_REACTION:R01523|MetaCyc:PHOSPHORIBULOKINASE-RXN|RHEA:19365 go.json 5-phosphoribulose kinase activity|ATP:D-ribulose-5-phosphate 1-phosphotransferase activity|PKK|PRK|PRuK|phosphopentokinase activity|phosphoribulokinase (phosphorylating)|ribulose phosphate kinase activity|ribulose-5-phosphate kinase activity http://purl.obolibrary.org/obo/GO_0008974 GO:0008973 biolink:MolecularActivity phosphopentomutase activity Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. EC:5.4.2.7|MetaCyc:PPENTOMUT-RXN|RHEA:18793|Reactome:R-HSA-6787329|Reactome:R-HSA-8982667 go.json D-ribose 1,5-phosphomutase activity|alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity|alpha-D-ribose 1,5-phosphomutase activity|deoxyribomutase activity|deoxyribose phosphomutase activity|phosphodeoxyribomutase activity|phosphoribomutase activity http://purl.obolibrary.org/obo/GO_0008973 GO:0008972 biolink:MolecularActivity phosphomethylpyrimidine kinase activity Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. EC:2.7.4.7|MetaCyc:PYRIMSYN3-RXN|RHEA:19893 go.json ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity|hydroxymethylpyrimidine phosphokinase activity http://purl.obolibrary.org/obo/GO_0008972 GO:0008971 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008971 GO:0008970 biolink:MolecularActivity phospholipase A1 activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. EC:3.1.1.32|MetaCyc:PHOSPHOLIPASE-A1-RXN|RHEA:18689|Reactome:R-HSA-1482827|Reactome:R-HSA-1482828|Reactome:R-HSA-1482847|Reactome:R-HSA-1482862|Reactome:R-HSA-1482892|Reactome:R-HSA-1482920|Reactome:R-HSA-1482932|Reactome:R-HSA-5694485 go.json phosphatidylcholine 1-acylhydrolase activity http://purl.obolibrary.org/obo/GO_0008970 goslim_chembl GO:0033919 biolink:MolecularActivity glucan 1,3-alpha-glucosidase activity Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. EC:3.2.1.84|MetaCyc:3.2.1.84-RXN|Reactome:R-HSA-532667|Reactome:R-HSA-548890|Reactome:R-HSA-9683663|Reactome:R-HSA-9694364 go.json 1,3-alpha-D-glucan 3-glucohydrolase activity|exo-1,3-alpha-glucanase activity http://purl.obolibrary.org/obo/GO_0033919 GO:0033918 biolink:MolecularActivity kappa-carrageenase activity Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans. EC:3.2.1.83|MetaCyc:3.2.1.83-RXN go.json kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity|kappa-carrageenan 4-beta-D-glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0033918 GO:0033917 biolink:MolecularActivity exo-poly-alpha-galacturonosidase activity Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate. EC:3.2.1.82|MetaCyc:3.2.1.82-RXN|RHEA:56232 go.json exopolygalacturanosidase activity|exopolygalacturonosidase activity http://purl.obolibrary.org/obo/GO_0033917 OBO:GOREL_0012006 biolink:OntologyClass results in maintenance of GOREL:0012006 go.json http://purl.obolibrary.org/obo/GOREL_0012006 GO:0033905 biolink:MolecularActivity xylan endo-1,3-beta-xylosidase activity Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans. EC:3.2.1.32|MetaCyc:3.2.1.32-RXN go.json 1,3-beta-D-xylan xylanohydrolase activity|1,3-beta-xylanase activity|1,3-xylanase activity|beta-1,3-xylanase activity|endo-1,3-beta-xylanase activity|endo-1,3-xylanase activity|endo-beta-1,3-xylanase activity|xylanase activity http://purl.obolibrary.org/obo/GO_0033905 GO:0008949 biolink:MolecularActivity oxalyl-CoA decarboxylase activity Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA. EC:4.1.1.8|KEGG_REACTION:R01908|MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN|RHEA:19333 go.json oxalyl coenzyme A decarboxylase activity|oxalyl-CoA carboxy-lyase (formyl-CoA-forming)|oxalyl-CoA carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0008949 GO:0008948 biolink:MolecularActivity oxaloacetate decarboxylase activity Catalysis of the reaction: oxaloacetate = pyruvate + CO2. EC:1.1.1.38|EC:1.1.1.40|EC:4.1.1.112|KEGG_REACTION:R00217|MetaCyc:OXALODECARB-RXN|RHEA:15641|Reactome:R-HSA-9012016 go.json oxalacetic acid decarboxylase activity|oxalate beta-decarboxylase activity|oxaloacetate beta-decarboxylase activity|oxaloacetate carboxy-lyase (pyruvate-forming)|oxaloacetate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0008948 GO:0033904 biolink:MolecularActivity dextranase activity Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran. EC:3.2.1.11|MetaCyc:3.2.1.11-RXN go.json 1,6-alpha-D-glucan 6-glucanohydrolase activity|DL 2|alpha-1,6-glucan-6-glucanohydrolase activity|alpha-D-1,6-glucan-6-glucanohydrolase activity|dextran hydrolase activity|dextranase DL 2 activity|endo-dextranase activity|endodextranase activity http://purl.obolibrary.org/obo/GO_0033904 GO:0033903 biolink:MolecularActivity obsolete endo-1,3(4)-beta-glucanase activity OBSOLETE. Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. EC:3.2.1.6|MetaCyc:3.2.1.6-RXN go.json 1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity|beta-1,3-1,4-glucanase activity|beta-1,3-glucanase activity|endo-1,3(4)-beta-glucanase activity|endo-1,3-1,4-beta-D-glucanase activity|endo-1,3-beta-D-glucanase activity|endo-1,3-beta-glucanase activity|endo-1,4-beta-glucanase activity|endo-beta-(1,3)-D-glucanase activity|endo-beta-(1->3)-D-glucanase activity|endo-beta-1,3(4)-glucanase activity|endo-beta-1,3-1,4-glucanase activity|endo-beta-1,3-glucanase IV activity|laminaranase activity|laminarinase activity True http://purl.obolibrary.org/obo/GO_0033903 GO:0008947 biolink:MolecularActivity obsolete omptin activity OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys. go.json omptin activity True http://purl.obolibrary.org/obo/GO_0008947 GO:0033902 biolink:MolecularActivity rRNA endonuclease activity Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes. EC:4.6.1.23|MetaCyc:3.1.27.10-RXN go.json alpha-sarcin http://purl.obolibrary.org/obo/GO_0033902 GO:0008946 biolink:MolecularActivity oligonucleotidase activity Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates. EC:3.1.13.3|MetaCyc:3.1.13.3-RXN go.json http://purl.obolibrary.org/obo/GO_0008946 GO:0008945 biolink:MolecularActivity obsolete oligopeptidase B activity OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline. go.json Escherichia coli alkaline proteinase II|oligopeptidase B activity|protease II activity True http://purl.obolibrary.org/obo/GO_0008945 GO:0033901 biolink:MolecularActivity ribonuclease V activity Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP. EC:3.1.27.8|MetaCyc:3.1.27.8-RXN go.json endoribonuclease V activity http://purl.obolibrary.org/obo/GO_0033901 GO:0008944 biolink:MolecularActivity obsolete oligopeptidase A activity OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5. go.json 68000-M signalpeptide hydrolase activity|oligopeptidase A activity True http://purl.obolibrary.org/obo/GO_0008944 GO:0033900 biolink:MolecularActivity ribonuclease F activity Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups. EC:3.1.27.7|MetaCyc:3.1.27.7-RXN go.json RNase F activity|ribonuclease F (E. coli) activity http://purl.obolibrary.org/obo/GO_0033900 GO:0008943 biolink:MolecularActivity obsolete glyceraldehyde-3-phosphate dehydrogenase activity OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+. go.json glyceraldehyde-3-phosphate dehydrogenase activity True http://purl.obolibrary.org/obo/GO_0008943 GO:0008942 biolink:MolecularActivity nitrite reductase [NAD(P)H] activity Catalysis of the reaction: NH4+ + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+. EC:1.7.1.4|KEGG_REACTION:R00787|KEGG_REACTION:R00789|MetaCyc:RXN0-6377 go.json NAD(P)H2:nitrite oxidoreductase activity|NAD(P)H:nitrite oxidoreductase activity|NADH-nitrite oxidoreductase activity|NADPH-nitrite reductase activity|ammonium-hydroxide:NAD(P)+ oxidoreductase activity|assimilatory nitrite reductase activity|nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity|nitrite reductase [NAD(P)H2] http://purl.obolibrary.org/obo/GO_0008942 GO:0008941 biolink:MolecularActivity nitric oxide dioxygenase activity Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+. EC:1.14.12.17|MetaCyc:R621-RXN|Reactome:R-HSA-1222723|Reactome:R-HSA-5340226 go.json NOD activity|nitric oxide,NAD(P)H:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008941 GO:0008940 biolink:MolecularActivity nitrate reductase activity Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. EC:1.7.99.4|MetaCyc:NITRATREDUCT-RXN|RHEA:21068 go.json nitrate reductase (acceptor)|nitrite:(acceptor) oxidoreductase|nitrite:acceptor oxidoreductase|respiratory nitrate reductase activity http://purl.obolibrary.org/obo/GO_0008940 GO:0033909 biolink:MolecularActivity fucoidanase activity Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate. EC:3.2.1.211|MetaCyc:RXN-20949 go.json poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity http://purl.obolibrary.org/obo/GO_0033909 GO:0033908 biolink:MolecularActivity beta-L-rhamnosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides. EC:3.2.1.43|MetaCyc:3.2.1.43-RXN go.json beta-L-rhamnoside rhamnohydrolase activity http://purl.obolibrary.org/obo/GO_0033908 GO:0033907 biolink:MolecularActivity beta-D-fucosidase activity Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides. EC:3.2.1.38|MetaCyc:3.2.1.38-RXN go.json beta-D-fucoside fucohydrolase activity|beta-fucosidase activity http://purl.obolibrary.org/obo/GO_0033907 GO:0033906 biolink:MolecularActivity hyaluronoglucuronidase activity Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. EC:3.2.1.36|MetaCyc:3.2.1.36-RXN go.json glucuronoglucosaminoglycan hyaluronate lyase activity|hyaluronate 3-glycanohydrolase activity|hyaluronidase activity|orgelase activity http://purl.obolibrary.org/obo/GO_0033906 GO:0008959 biolink:MolecularActivity phosphate acetyltransferase activity Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. EC:2.3.1.8|MetaCyc:PHOSACETYLTRANS-RXN|RHEA:19521 go.json PTA|acetyl-CoA:phosphate acetyltransferase activity|phosphoacylase activity|phosphotransacetylase activity http://purl.obolibrary.org/obo/GO_0008959 GO:0008958 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008958 GO:0008957 biolink:MolecularActivity phenylacetaldehyde dehydrogenase activity Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+. EC:1.2.1.39|MetaCyc:PHENDEHYD-RXN|RHEA:21392|UM-BBD_reactionID:r0035 go.json phenylacetaldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008957 GO:0008956 biolink:MolecularActivity obsolete peptidyl-dipeptidase Dcp activity OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly. EC:3.4.15.5|MetaCyc:3.4.15.5-RXN go.json dipeptidyl carboxypeptidase (Dcp)|dipeptidyl carboxypeptidase activity|peptidyl-dipeptidase Dcp activity True http://purl.obolibrary.org/obo/GO_0008956 GO:0008955 biolink:MolecularActivity peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. EC:2.4.1.129|MetaCyc:RXN-14712|RHEA:23708 go.json PG-II activity|bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity|penicillin binding protein (3 or 1B) activity|peptidoglycan TGase activity|peptidoglycan transglycosylase activity|undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity http://purl.obolibrary.org/obo/GO_0008955 GO:0008954 biolink:MolecularActivity obsolete peptidoglycan synthetase activity OBSOLETE. (Was not defined before being made obsolete). go.json peptidoglycan synthetase activity True http://purl.obolibrary.org/obo/GO_0008954 GO:0008953 biolink:MolecularActivity penicillin amidase activity Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate. EC:3.5.1.11|MetaCyc:PENICILLIN-AMIDASE-RXN|RHEA:18693 go.json alpha-acylamino-beta-lactam acylhydrolase activity|ampicillin acylase activity|benzylpenicillin acylase activity|novozym 217|palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity|penicillin acylase activity|penicillin amidohydrolase activity|semacylase activity http://purl.obolibrary.org/obo/GO_0008953 GO:0008952 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008952 GO:0008951 biolink:MolecularActivity palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]. MetaCyc:PALMITOTRANS-RXN|RHEA:44012 go.json palmitoleoyl ACP-dependent acyltransferase activity http://purl.obolibrary.org/obo/GO_0008951 GO:0008950 biolink:MolecularActivity obsolete p-aminobenzoate synthetase OBSOLETE. (Was not defined before being made obsolete). go.json p-aminobenzoate synthetase True http://purl.obolibrary.org/obo/GO_0008950 GO:0008927 biolink:MolecularActivity mannonate dehydratase activity Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. EC:4.2.1.8|KEGG_REACTION:R05606|MetaCyc:MANNONDEHYDRAT-RXN|RHEA:20097 go.json D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)|D-mannonate hydro-lyase activity|D-mannonate hydrolyase activity|altronate hydrolase activity|altronic hydro-lyase activity|mannonate hydrolyase activity|mannonic hydrolase activity http://purl.obolibrary.org/obo/GO_0008927 GO:0008926 biolink:MolecularActivity mannitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. EC:1.1.1.17|MetaCyc:MANNPDEHYDROG-RXN|RHEA:19661 go.json http://purl.obolibrary.org/obo/GO_0008926 GO:0008925 biolink:MolecularActivity maltose O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose. EC:2.3.1.79|MetaCyc:MALTACETYLTRAN-RXN|RHEA:10456 go.json acetyl-CoA:maltose O-acetyltransferase activity|maltose transacetylase activity http://purl.obolibrary.org/obo/GO_0008925 GO:0008924 biolink:MolecularActivity malate dehydrogenase (quinone) activity Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol. EC:1.1.5.4|MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN|RHEA:46012 go.json (S)-malate:(quinone) oxidoreductase activity|(S)-malate:quinone oxidoreductase activity|FAD-dependent malate dehydrogenase activity|MQO activity http://purl.obolibrary.org/obo/GO_0008924 GO:0008923 biolink:MolecularActivity lysine decarboxylase activity Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2. EC:4.1.1.18|KEGG_REACTION:R00462|MetaCyc:LYSDECARBOX-RXN|RHEA:22352 go.json L-lysine carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0008923 GO:0008922 biolink:MolecularActivity long-chain fatty acid [acyl-carrier-protein] ligase activity Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. EC:6.2.1.20|KEGG_REACTION:R07325|MetaCyc:ACYLACPSYNTH-RXN|RHEA:45588 go.json acyl-ACP synthetase activity|acyl-[acyl-carrier-protein] synthetase activity|acyl-acyl carrier protein synthetase|acyl-acyl-carrier-protein synthetase activity|acyl-acyl-carrier-proteinsynthetase activity|long-chain fatty acid-[acyl-carrier-protein] ligase activity|long-chain-fatty-acid-ACP ligase activity|long-chain-fatty-acid-[acyl-carrier protein] ligase activity|long-chain-fatty-acid-[acyl-carrier-protein] ligase activity|long-chain-fatty-acid-acyl-carrier-protein ligase activity|long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity|stearoyl-ACP synthetase activity http://purl.obolibrary.org/obo/GO_0008922 GO:0008921 biolink:MolecularActivity lipopolysaccharide-1,6-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide. go.json LPS-1,6-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0008921 GO:0008920 biolink:MolecularActivity lipopolysaccharide heptosyltransferase activity Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. go.json LPS heptosyltransferase activity http://purl.obolibrary.org/obo/GO_0008920 GO:0008929 biolink:MolecularActivity methylglyoxal synthase activity Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. EC:4.2.3.3|KEGG_REACTION:R01016|MetaCyc:METHGLYSYN-RXN|RHEA:17937 go.json glycerone-phosphate phospho-lyase (methylglyoxal-forming)|glycerone-phosphate phospho-lyase activity|methylglyoxal synthetase activity http://purl.obolibrary.org/obo/GO_0008929 GO:0008928 biolink:MolecularActivity mannose-1-phosphate guanylyltransferase (GDP) activity Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate. EC:2.7.7.22|KEGG_REACTION:R00883|MetaCyc:MANNPGUANYLTRANGDP-RXN|RHEA:12905 go.json GDP mannose phosphorylase activity|GDP-mannose 1-phosphate guanylyltransferase activity|GDP-mannose phosphorylase activity|GDP-mannose pyrophosphorylase activity|GDP:D-mannose-1-phosphate guanylyltransferase activity|GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity|GDP:mannose-1-phosphate guanylyltransferase activity|guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity|guanosine diphosphomannose phosphorylase activity|mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity|mannose 1-phosphate guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0008928 GO:0008938 biolink:MolecularActivity nicotinate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine. EC:2.1.1.7|KEGG_REACTION:R01721|MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN|RHEA:20241 go.json S-adenosyl-L-methionine:nicotinate N-methyltransferase activity|furanocoumarin 8-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008938 GO:0008937 biolink:MolecularActivity ferredoxin-NAD(P) reductase activity Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+. go.json ferredoxin reductase activity http://purl.obolibrary.org/obo/GO_0008937 gocheck_do_not_annotate GO:0008936 biolink:MolecularActivity nicotinamidase activity Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3. EC:3.5.1.19|MetaCyc:NICOTINAMID-RXN|RHEA:14545 go.json NAMase activity|YNDase activity|nicotinamide amidase activity|nicotinamide amidohydrolase activity|nicotinamide deaminase activity|nicotine deamidase activity http://purl.obolibrary.org/obo/GO_0008936 GO:0008935 biolink:MolecularActivity 1,4-dihydroxy-2-naphthoyl-CoA synthase activity Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O. EC:4.1.3.36|KEGG_REACTION:R04150|MetaCyc:NAPHTHOATE-SYN-RXN|RHEA:26562 go.json DHNA synthetase activity|O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity|dihydroxynaphthoate synthase activity|dihydroxynaphthoic acid synthetase activity|naphthoate synthase activity http://purl.obolibrary.org/obo/GO_0008935 GO:0008934 biolink:MolecularActivity inositol monophosphate 1-phosphatase activity Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. EC:3.1.3.25|MetaCyc:RXN0-5408|RHEA:27670|Reactome:R-HSA-1855154 go.json L-myo-inositol-1-phosphate phosphatase activity|inositol 1-phosphatase activity|inositol-1(or 4)-monophosphatase activity|myo-inositol 1-phosphatase activity|myo-inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity|myo-inositol-1-phosphatase activity http://purl.obolibrary.org/obo/GO_0008934 GO:0008933 biolink:MolecularActivity lytic transglycosylase activity Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. go.json murein transglycosylase B activity|peptidoglycan lytic transglycosylase activity http://purl.obolibrary.org/obo/GO_0008933 GO:0008932 biolink:MolecularActivity lytic endotransglycosylase activity Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends. EC:4.2.2.n2 go.json murein lytic endotransglycosylase E activity http://purl.obolibrary.org/obo/GO_0008932 GO:0008931 biolink:MolecularActivity obsolete murein DD-endopeptidase activity OBSOLETE. (Was not defined before being made obsolete). go.json murein DD-endopeptidase activity True http://purl.obolibrary.org/obo/GO_0008931 GO:0008930 biolink:MolecularActivity methylthioadenosine nucleosidase activity Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose. EC:3.2.2.16|MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN|RHEA:13617 go.json 5'-methylthioadenosine nucleosidase activity|MTA nucleosidase activity|MeSAdo nucleosidase activity|S-methyl-5'-thioadenosine adeninehyrolase activity|methylthioadenosine methylthioribohydrolase activity http://purl.obolibrary.org/obo/GO_0008930 GO:0008939 biolink:MolecularActivity nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. EC:2.4.2.21|KEGG_REACTION:R04148|MetaCyc:DMBPPRIBOSYLTRANS-RXN|RHEA:11196 go.json CobT|N(1)-alpha-phosphoribosyltransferase activity|N1-alpha-phosphoribosyltransferase activity|nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity|nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity|nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity|nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity|nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0008939 GO:0008905 biolink:MolecularActivity obsolete mannose-phosphate guanylyltransferase activity OBSOLETE. Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. go.json True http://purl.obolibrary.org/obo/GO_0008905 GO:0008904 biolink:MolecularActivity hygromycin-B 7''-O-phosphotransferase activity Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H+. EC:2.7.1.119|KEGG_REACTION:R03770|MetaCyc:HYGROMYCIN-B-KINASE-RXN|RHEA:23388 go.json APH(7'') activity|ATP:hygromycin-B 7''-O-phosphotransferase activity|destomic acid ring 7''-O-phosphotransferase activity|hygromycin B kinase activity|hygromycin B phosphotransferase activity|hygromycin-B kinase activity http://purl.obolibrary.org/obo/GO_0008904 GO:0008903 biolink:MolecularActivity hydroxypyruvate isomerase activity Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. EC:5.3.1.22|KEGG_REACTION:R01394|MetaCyc:RXN0-305|RHEA:11952 go.json hydroxypyruvate aldose-ketose-isomerase activity|hydroxypyruvate ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0008903 GO:0008902 biolink:MolecularActivity hydroxymethylpyrimidine kinase activity Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+. EC:2.7.1.49|KEGG_REACTION:R03471|MetaCyc:OHMETPYRKIN-RXN|RHEA:23096 go.json ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity|hydroxymethylpyrimidine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0008902 GO:0008901 biolink:MolecularActivity ferredoxin hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. EC:1.12.7.2|MetaCyc:HYDROG-RXN|RHEA:17445|UM-BBD_enzymeID:e0418 go.json H(2) oxidizing hydrogenase activity|H(2) producing hydrogenase activity|H2 oxidizing hydrogenase|H2 producing hydrogenase|Ni-Fe hydrogenase activity|Ni-Fe-Se hydrogenase activity|[Fe] hydrogenase activity|[Fe] hydrogenase gamma|bidirectional hydrogenase activity|hydrogen-lyase activity|hydrogen:ferredoxin oxidoreductase activity|hydrogenase (ferredoxin) activity|hydrogenase I|hydrogenase II|hydrogenase activity|hydrogenlyase activity|iron hydrogenase activity|iron-only hydrogenase activity|nickel hydrogenase activity|nickel-iron hydrogenase activity|nickel-iron-selenium hydrogenase activity|uptake hydrogenase activity http://purl.obolibrary.org/obo/GO_0008901 GO:0008900 biolink:MolecularActivity P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). EC:7.2.2.19|RHEA:22044|Reactome:R-HSA-937311|Reactome:R-HSA-9727198 go.json (K+ + H+)-ATPase activity|ATP phosphohydrolase (H+/K+-exchanging)|H+-K+-ATPase activity|H+/K(+)-ATPase activity|H+/K(+)-exchanging ATPase activity|H+/K+-ATPase activity|H+/K+-exchanging ATPase activity|H,K-ATPase activity|gastric H+/K(+) ATPase activity|gastric H+/K+ ATPase|hydrogen/potassium-exchanging ATPase activity|hydrogen:potassium exchanging ATPase activity|hydrogen:potassium-exchanging ATPase activity|potassium:proton exchanging ATPase activity|proton pump activity http://purl.obolibrary.org/obo/GO_0008900 GO:0008909 biolink:MolecularActivity isochorismate synthase activity Catalysis of the reaction: chorismate = isochorismate. EC:5.4.4.2|KEGG_REACTION:R01717|MetaCyc:ISOCHORSYN-RXN|RHEA:18985 go.json isochorismate hydroxymutase activity|isochorismate mutase activity|isochorismate synthetase activity http://purl.obolibrary.org/obo/GO_0008909 GO:0008908 biolink:MolecularActivity isochorismatase activity Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. EC:3.3.2.1|KEGG_REACTION:R03037|MetaCyc:ISOCHORMAT-RXN|RHEA:11112 go.json 2,3 dihydro-2,3 dihydroxybenzoate synthase activity|2,3-dihydro-2,3-dihydroxybenzoate synthase activity|2,3-dihydroxy-2,3-dihydrobenzoate synthase activity|2,3-dihydroxy-2,3-dihydrobenzoic synthase activity|isochorismate pyruvate-hydrolase activity http://purl.obolibrary.org/obo/GO_0008908 GO:0008907 biolink:MolecularActivity integrase activity Catalysis of the integration of one DNA segment into another. Reactome:R-HSA-164523 go.json http://purl.obolibrary.org/obo/GO_0008907 goslim_pir GO:0008906 biolink:MolecularActivity inosine kinase activity Catalysis of the reaction: ATP + inosine = ADP + IMP. EC:2.7.1.73|MetaCyc:INOSINEKIN-RXN|RHEA:21140 go.json ATP:inosine 5'-phosphotransferase activity|inosine kinase (phosphorylating)|inosine-guanosine kinase activity http://purl.obolibrary.org/obo/GO_0008906 GO:0008916 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008916 GO:0008915 biolink:MolecularActivity lipid-A-disaccharide synthase activity Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP. EC:2.4.1.182|KEGG_REACTION:R04606|MetaCyc:LIPIDADISACCHARIDESYNTH-RXN|RHEA:22668 go.json UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0008915 GO:0008914 biolink:MolecularActivity leucyl-tRNA--protein transferase activity Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue. EC:2.3.2.6|MetaCyc:LEUCYLTRANSFERASE-RXN go.json L/F transferase activity|leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity|leucyl-phenylalanine-transfer ribonucleate-protein transferase activity|leucyltransferase activity http://purl.obolibrary.org/obo/GO_0008914 GO:0008913 biolink:MolecularActivity lauroyltransferase activity Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another. go.json lauroyl transferase activity http://purl.obolibrary.org/obo/GO_0008913 GO:0008912 biolink:MolecularActivity lactaldehyde reductase activity Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+. EC:1.1.1.77 go.json (R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity|lactaldehyde:propanediol oxidoreductase activity|propanediol oxidoreductase activity|propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008912 GO:0008911 biolink:MolecularActivity lactaldehyde dehydrogenase activity Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+. EC:1.2.1.22|MetaCyc:LACTALDDEHYDROG-RXN|RHEA:14277 go.json (S)-lactaldehyde:NAD+ oxidoreductase activity|L-lactaldehyde:NAD oxidoreductase activity|nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008911 GO:0008910 biolink:MolecularActivity kanamycin kinase activity Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate. EC:2.7.1.95|KEGG_REACTION:R01888|MetaCyc:KANAMYCIN-KINASE-RXN|RHEA:24256 go.json APH(3') activity|ATP:kanamycin 3'-O-phosphotransferase activity|aminoglycoside 3'-phosphotransferase activity|kanamycin kinase (phosphorylating)|neomycin phosphotransferase activity|neomycin-kanamycin phosphotransferase activity http://purl.obolibrary.org/obo/GO_0008910 GO:0008919 biolink:MolecularActivity lipopolysaccharide glucosyltransferase I activity Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide. EC:2.4.1.58|MetaCyc:RXN0-5126 go.json LPS glucosyltransferase I activity|UDP-glucose:lipopolysaccharide glucosyltransferase activity|UDPglucose:lipopolysaccharide glucosyltransferase I|UDPglucose:lipopolysaccharide glucosyltransferase activity|lipopolysaccharide glucosyltransferase activity|uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I|uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0008919 GO:0008918 biolink:MolecularActivity lipopolysaccharide 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide. EC:2.4.1.44|MetaCyc:RXN-22172 go.json LPS 3-alpha-galactosyltransferase activity|UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity|UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity|UDP-galactose:polysaccharide galactosyltransferase activity|UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity|lipopolysaccharide 1,3-galactosyltransferase activity|lipopolysaccharide galactosyltransferase activity|lipopolysaccharide-alpha-1,3-D-galactosyltransferase|uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity|uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0008918 GO:0008917 biolink:MolecularActivity lipopolysaccharide N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide. EC:2.4.1.56|MetaCyc:RXN-22502 go.json LPS N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity|UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0008917 GO:0018490 biolink:MolecularActivity 4-hydroxyphenylpyruvate oxidase activity Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O2 = 2 (4-hydroxyphenyl)acetate + 2 CO2. EC:1.2.3.13|KEGG_REACTION:R00042|MetaCyc:1.2.3.13-RXN|RHEA:17197|UM-BBD_reactionID:r0299 go.json 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0018490 GO:0018492 biolink:MolecularActivity carbon-monoxide dehydrogenase (acceptor) activity Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor. EC:1.2.7.4|MetaCyc:1.2.7.4-RXN|RHEA:21040|UM-BBD_enzymeID:e0415 go.json anaerobic carbon monoxide dehydrogenase activity|carbon monoxide dehydrogenase activity|carbon-monoxide:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018492 GO:0018491 biolink:MolecularActivity 2-oxobutyrate synthase activity Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin. MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN|RHEA:32135|UM-BBD_reactionID:r0358 go.json 2-ketobutyrate synthase activity|2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)|2-oxobutyrate-ferredoxin oxidoreductase activity|alpha-ketobutyrate synthase activity|alpha-ketobutyrate-ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018491 GO:0043454 biolink:BiologicalProcess alkyne catabolic process The chemical reactions and pathways resulting in the breakdown of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. go.json alkyne breakdown|alkyne catabolism|alkyne degradation http://purl.obolibrary.org/obo/GO_0043454 GO:0043453 biolink:BiologicalProcess alkyne biosynthetic process The chemical reactions and pathways resulting in the formation of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. go.json alkyne anabolism|alkyne biosynthesis|alkyne formation|alkyne synthesis http://purl.obolibrary.org/obo/GO_0043453 GO:0043456 biolink:BiologicalProcess regulation of pentose-phosphate shunt Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis. go.json regulation of pentose phosphate pathway|regulation of pentose phosphate shunt|regulation of pentose-phosphate pathway http://purl.obolibrary.org/obo/GO_0043456 GO:0043455 biolink:BiologicalProcess regulation of secondary metabolic process Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. go.json regulation of secondary metabolism http://purl.obolibrary.org/obo/GO_0043455 GO:0043450 biolink:BiologicalProcess alkene biosynthetic process The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. go.json alkene anabolism|alkene biosynthesis|alkene formation|alkene synthesis http://purl.obolibrary.org/obo/GO_0043450 GO:0043452 biolink:BiologicalProcess cellular alkyne metabolic process The chemical reactions and pathways involving an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells. go.json alkyne metabolism http://purl.obolibrary.org/obo/GO_0043452 goslim_pir GO:0043451 biolink:BiologicalProcess alkene catabolic process The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. go.json alkene breakdown|alkene catabolism|alkene degradation http://purl.obolibrary.org/obo/GO_0043451 GO:0043458 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043458 GO:0043457 biolink:BiologicalProcess regulation of cellular respiration Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. go.json http://purl.obolibrary.org/obo/GO_0043457 GO:0043459 biolink:BiologicalProcess obsolete response to short exposure to lithium ion OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus. go.json response to short exposure to lithium ion True http://purl.obolibrary.org/obo/GO_0043459 GO:0018487 biolink:MolecularActivity vanillate O-demethylase (anaerobic) activity Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate. UM-BBD_reactionID:r0758 go.json http://purl.obolibrary.org/obo/GO_0018487 GO:0018486 biolink:MolecularActivity 2-butanone oxidase activity Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate. UM-BBD_reactionID:r0169 go.json http://purl.obolibrary.org/obo/GO_0018486 GO:0018489 biolink:MolecularActivity vanillate monooxygenase activity Catalysis of the reaction: H+ + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD+. EC:1.14.13.82|KEGG_REACTION:R05274|MetaCyc:RXN-10891|MetaCyc:RXN-2|RHEA:13021|UM-BBD_reactionID:r0146 go.json 4-hydroxy-3-methoxybenzoate demethylase activity|vanillate demethylase (aerobic) activity|vanillate demethylase activity|vanillate:oxygen oxidoreductase (demethylating) http://purl.obolibrary.org/obo/GO_0018489 GO:0018488 biolink:MolecularActivity aryl-aldehyde oxidase activity Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide. EC:1.2.3.9|MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN|RHEA:18569|UM-BBD_reactionID:r0145 go.json aryl-aldehyde:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018488 GO:0018483 biolink:MolecularActivity 6-oxohexanoate dehydrogenase activity Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+. EC:1.2.1.63|MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN|RHEA:13397|UM-BBD_reactionID:r0175 go.json 6-oxohexanoate:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018483 GO:0018482 biolink:MolecularActivity 4-formylbenzenesulfonate dehydrogenase activity Catalysis of the reaction: 4-formylbenzenesulfonate + H2O + NAD+ = 4-sulfobenzoate + 2 H+ + NADH. EC:1.2.1.62|KEGG_REACTION:R05272|MetaCyc:SYDDEHYD-RXN|RHEA:18833|UM-BBD_reactionID:r0292 go.json 4-formylbenzenesulfonate:NAD+ oxidoreductase activity|4-formylbenzenesulphonate dehydrogenase activity|toluene-sulfonate aldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018482 GO:0018485 biolink:MolecularActivity salicylaldehyde dehydrogenase activity Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+. EC:1.2.1.65|MetaCyc:1.2.1.65-RXN|RHEA:18537|UM-BBD_enzymeID:e0256 go.json salicylaldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018485 GO:0018484 biolink:MolecularActivity 4-hydroxybenzaldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+. EC:1.2.1.64|MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN|RHEA:20305|UM-BBD_reactionID:r0273 go.json 3-hydroxybenzaldehyde:NAD+ oxidoreductase activity|p-hydroxybenzaldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018484 GO:0043465 biolink:BiologicalProcess regulation of fermentation Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP). go.json http://purl.obolibrary.org/obo/GO_0043465 GO:0043464 biolink:BiologicalProcess malolactic fermentation The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP. Wikipedia:Malolactic_fermentation go.json L-malate fermentation|malate fermentation|malo-lactate fermentation|malolactate fermentation http://purl.obolibrary.org/obo/GO_0043464 GO:0043467 biolink:BiologicalProcess regulation of generation of precursor metabolites and energy Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. go.json http://purl.obolibrary.org/obo/GO_0043467 GO:0043466 biolink:BiologicalProcess pyrimidine nucleobase fermentation The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP. go.json pyrimidine base fermentation|pyrimidine fermentation http://purl.obolibrary.org/obo/GO_0043466 GO:0043461 biolink:BiologicalProcess proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. go.json F-type ATPase complex assembly http://purl.obolibrary.org/obo/GO_0043461 GO:0043460 biolink:BiologicalProcess obsolete response to long exposure to lithium ion OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus. go.json response to long exposure to lithium ion True http://purl.obolibrary.org/obo/GO_0043460 GO:0043463 biolink:BiologicalProcess regulation of rhamnose catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. go.json regulation of rhamnose breakdown|regulation of rhamnose catabolism|regulation of rhamnose degradation http://purl.obolibrary.org/obo/GO_0043463 GO:0043462 biolink:BiologicalProcess regulation of ATP-dependent activity Any process that modulates the rate of an ATP-dependent activity. go.json regulation of ATPase activity|regulation of adenosinetriphosphatase activity http://purl.obolibrary.org/obo/GO_0043462 gocheck_do_not_annotate GO:0043469 biolink:BiologicalProcess regulation of D-xylose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose. go.json http://purl.obolibrary.org/obo/GO_0043469 GO:0043468 biolink:BiologicalProcess regulation of fucose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose. go.json http://purl.obolibrary.org/obo/GO_0043468 GO:0018498 biolink:MolecularActivity 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate. MetaCyc:PHENPRODIOLDEHYDROG-RXN|RHEA:25062|UM-BBD_enzymeID:e0308 go.json http://purl.obolibrary.org/obo/GO_0018498 GO:0018497 biolink:MolecularActivity 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS. UM-BBD_reactionID:r0514 go.json DDMS dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018497 GO:0018499 biolink:MolecularActivity cis-2,3-dihydrodiol DDT dehydrogenase activity Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT. UM-BBD_reactionID:r0451 go.json http://purl.obolibrary.org/obo/GO_0018499 GO:0018494 biolink:MolecularActivity carvone reductase activity Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone. EC:1.3.99.25|MetaCyc:RXN-9403|MetaCyc:RXN-9419|UM-BBD_reactionID:r0732 go.json http://purl.obolibrary.org/obo/GO_0018494 GO:0018493 biolink:MolecularActivity formylmethanofuran dehydrogenase activity Catalysis of the reaction: N-formylmethanofuran + A + H2O + H+ = AH(2) + CO2 + methanofuran. EC:1.2.7.12|KEGG_REACTION:R03015|MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN|RHEA:19841|UM-BBD_reactionID:r0345 go.json formylmethanofuran:(acceptor) oxidoreductase activity|formylmethanofuran:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018493 GO:0018496 biolink:MolecularActivity 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA. UM-BBD_reactionID:r0205 go.json http://purl.obolibrary.org/obo/GO_0018496 GO:0018495 biolink:MolecularActivity 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA. UM-BBD_reactionID:r0192 go.json http://purl.obolibrary.org/obo/GO_0018495 GO:0018470 biolink:MolecularActivity 4-hydroxybutaraldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate. UM-BBD_reactionID:r0014 go.json http://purl.obolibrary.org/obo/GO_0018470 GO:0043470 biolink:BiologicalProcess regulation of carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. go.json http://purl.obolibrary.org/obo/GO_0043470 GO:0043476 biolink:BiologicalProcess pigment accumulation The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. go.json pigment accumulation in response to external stimulus http://purl.obolibrary.org/obo/GO_0043476 GO:0043475 biolink:BiologicalProcess pigment metabolic process involved in pigment accumulation The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment. go.json pigment metabolic process during pigment accumulation|pigment metabolism during pigment accumulation http://purl.obolibrary.org/obo/GO_0043475 GO:0043478 biolink:BiologicalProcess pigment accumulation in response to UV light The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus. go.json http://purl.obolibrary.org/obo/GO_0043478 GO:0043477 biolink:BiologicalProcess pigment biosynthetic process involved in pigment accumulation The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation. go.json pigment biosynthetic process during pigment accumulation http://purl.obolibrary.org/obo/GO_0043477 GO:0043472 biolink:MolecularActivity IgD binding Binding to an immunoglobulin of a D isotype. go.json http://purl.obolibrary.org/obo/GO_0043472 GO:0043471 biolink:BiologicalProcess obsolete regulation of cellular carbohydrate catabolic process OBSOLETE. Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. go.json True http://purl.obolibrary.org/obo/GO_0043471 GO:0043474 biolink:BiologicalProcess pigment metabolic process involved in pigmentation The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell. go.json pigment metabolic process during pigmentation|pigment metabolism during pigmentation http://purl.obolibrary.org/obo/GO_0043474 GO:0043473 biolink:BiologicalProcess pigmentation The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. go.json http://purl.obolibrary.org/obo/GO_0043473 goslim_chembl|goslim_pir GO:0018469 biolink:MolecularActivity myrtenal dehydrogenase activity Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid. UM-BBD_reactionID:r0711 go.json http://purl.obolibrary.org/obo/GO_0018469 GO:0043479 biolink:BiologicalProcess pigment accumulation in tissues in response to UV light The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus. go.json http://purl.obolibrary.org/obo/GO_0043479 GO:0018468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018468 GO:0018465 biolink:MolecularActivity vanillyl-alcohol oxidase activity Catalysis of the reaction: O2 + vanillyl alcohol = H2O2 + vanillin. EC:1.1.3.38|KEGG_REACTION:R02877|MetaCyc:1.1.3.38-RXN|RHEA:10036|UM-BBD_reactionID:r0651 go.json 4-hydroxy-2-methoxybenzyl alcohol oxidase activity|vanillyl alcohol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018465 GO:0018464 biolink:MolecularActivity 3-hydroxypimeloyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD+ = 3-oxopimelyl-CoA + H+ + NADH. EC:1.1.1.259|KEGG_REACTION:R05305|MetaCyc:1.1.1.259-RXN|RHEA:11168|UM-BBD_reactionID:r0196 go.json 3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018464 GO:0018467 biolink:MolecularActivity formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH. EC:1.2.1.46|KEGG_REACTION:R00604|MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN|RHEA:16425|UM-BBD_reactionID:r0240 go.json formaldehyde:NAD+ oxidoreductase activity|glutathione-independent formaldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018467 GO:0018466 biolink:MolecularActivity limonene-1,2-diol dehydrogenase activity Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene. EC:1.1.99.-|UM-BBD_reactionID:r0735 go.json http://purl.obolibrary.org/obo/GO_0018466 GO:0018461 biolink:MolecularActivity fluoren-9-ol dehydrogenase activity Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+. EC:1.1.1.256|MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN|UM-BBD_reactionID:r0408 go.json 9-fluorenol dehydrogenase activity|fluoren-9-ol:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018461 GO:0018460 biolink:MolecularActivity cyclohexanol dehydrogenase activity Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+. EC:1.1.1.245|MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN|RHEA:10044|UM-BBD_reactionID:r0165 go.json cyclohexanol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018460 GO:0018463 biolink:MolecularActivity 6-hydroxyhexanoate dehydrogenase activity Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + H+ + NADH. EC:1.1.1.258|KEGG_REACTION:R05283|MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN|RHEA:14225|UM-BBD_reactionID:r0174 go.json 6-hydroxyhexanoate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018463 GO:0018462 biolink:MolecularActivity 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + H+ + NADH. EC:1.1.1.257|KEGG_REACTION:R05271|MetaCyc:SOLDEHYD-RXN|RHEA:24412|UM-BBD_reactionID:r0291 go.json 4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity|4-(hydroxymethyl)benzenesulphonate dehydrogenase activity|4-sulfobenzyl alcohol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018462 GO:0018481 biolink:MolecularActivity 4-hydroxymuconic-semialdehyde dehydrogenase activity Catalysis of the reaction: cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD+ = 2 H+ + maleylacetate + NADH. EC:1.2.1.61|KEGG_REACTION:R05236|MetaCyc:1.2.1.61-RXN|RHEA:22420|UM-BBD_reactionID:r0229 go.json 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018481 GO:0043481 biolink:BiologicalProcess anthocyanin accumulation in tissues in response to UV light The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus. go.json http://purl.obolibrary.org/obo/GO_0043481 GO:0043480 biolink:BiologicalProcess pigment accumulation in tissues The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus. go.json organismal pigment accumulation http://purl.obolibrary.org/obo/GO_0043480 GO:0018480 biolink:MolecularActivity 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+. EC:1.2.1.60|MetaCyc:CHMS-DEHYDROGENASE-RXN|RHEA:15681|UM-BBD_reactionID:r0365 go.json 5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity|carboxymethylhydroxymuconic semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018480 GO:0043487 biolink:BiologicalProcess regulation of RNA stability Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. go.json http://purl.obolibrary.org/obo/GO_0043487 GO:0043486 biolink:BiologicalProcess obsolete histone exchange OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. go.json histone chaperone|histone replacement True http://purl.obolibrary.org/obo/GO_0043486 GO:0043489 biolink:BiologicalProcess RNA stabilization Prevention of degradation of RNA molecules. go.json http://purl.obolibrary.org/obo/GO_0043489 GO:0043488 biolink:BiologicalProcess regulation of mRNA stability Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. go.json http://purl.obolibrary.org/obo/GO_0043488 GO:0043483 biolink:BiologicalProcess anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus. go.json anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus|anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light|anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus http://purl.obolibrary.org/obo/GO_0043483 GO:0043482 biolink:BiologicalProcess cellular pigment accumulation The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. go.json http://purl.obolibrary.org/obo/GO_0043482 GO:0043485 biolink:BiologicalProcess endosome to pigment granule transport The directed movement of substances from endosomes to pigment granules. go.json http://purl.obolibrary.org/obo/GO_0043485 GO:0043484 biolink:BiologicalProcess regulation of RNA splicing Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. go.json http://purl.obolibrary.org/obo/GO_0043484 GO:0018479 biolink:MolecularActivity benzaldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. EC:1.2.1.28|MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN|RHEA:11840|UM-BBD_reactionID:r0269 go.json benzaldehyde (NAD) dehydrogenase activity|benzaldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018479 GO:0018476 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018476 GO:0018475 biolink:MolecularActivity trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid. UM-BBD_reactionID:r0745 go.json http://purl.obolibrary.org/obo/GO_0018475 GO:0018478 biolink:MolecularActivity malonate-semialdehyde dehydrogenase (acetylating) activity Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. EC:1.2.1.18|MetaCyc:RXN-9958 go.json 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)|malonic semialdehyde oxidative decarboxylase activity http://purl.obolibrary.org/obo/GO_0018478 GO:0018477 biolink:MolecularActivity benzaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+. EC:1.2.1.7|MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN|RHEA:21660|UM-BBD_enzymeID:e0079 go.json NADP-linked benzaldehyde dehydrogenase|benzaldehyde:NADP+ oxidoreductase http://purl.obolibrary.org/obo/GO_0018477 GO:0018472 biolink:MolecularActivity 1-hydroxy-2-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate. UM-BBD_reactionID:r0485 go.json http://purl.obolibrary.org/obo/GO_0018472 GO:0018471 biolink:MolecularActivity 4-chlorobenzaldehyde oxidase activity Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-. EC:1.14.13.-|UM-BBD_reactionID:r0447 go.json http://purl.obolibrary.org/obo/GO_0018471 GO:0018474 biolink:MolecularActivity 2-carboxybenzaldehyde dehydrogenase activity Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate. EC:1.2.1.-|UM-BBD_reactionID:r0490 go.json http://purl.obolibrary.org/obo/GO_0018474 GO:0018473 biolink:MolecularActivity cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid. UM-BBD_reactionID:r0744 go.json http://purl.obolibrary.org/obo/GO_0018473 GO:0043490 biolink:BiologicalProcess malate-aspartate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle. Wikipedia:Malate-aspartate_shuttle go.json malate aspartate shuttle|malate/aspartate shuttle|malate:aspartate shuttle http://purl.obolibrary.org/obo/GO_0043490 GO:0043492 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043492 GO:0043491 biolink:BiologicalProcess phosphatidylinositol 3-kinase/protein kinase B signal transduction An intracellular signal transduction pathway that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. go.json AKT signal transduction|AKT signaling|AKT signaling cascade|AKT signalling cascade|PI3K-PKB/Akt pathway|PI3K/Akt signal transduction|PI3K/PKB signal transduction|PKB signal transduction|PKB signaling|PKB signaling cascade|PKB signalling cascade|phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction|protein kinase B signal transduction|protein kinase B signaling|protein kinase B signaling cascade|protein kinase B signalling cascade http://purl.obolibrary.org/obo/GO_0043491 GO:0043498 biolink:MolecularActivity obsolete cell surface binding OBSOLETE. Binding to a component on the surface of a cell. go.json cell surface binding True http://purl.obolibrary.org/obo/GO_0043498 GO:0043497 biolink:BiologicalProcess regulation of protein heterodimerization activity Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer. go.json http://purl.obolibrary.org/obo/GO_0043497 gocheck_do_not_annotate GO:0043499 biolink:MolecularActivity obsolete eukaryotic cell surface binding OBSOLETE. Binding to a component on the surface of a eukaryotic cell. go.json eukaryotic cell surface binding True http://purl.obolibrary.org/obo/GO_0043499 GO:0043494 biolink:CellularComponent CLRC complex An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi. go.json CLRC ubiquitin ligase complex|Clr4-Rik1-Cul4 complex|Rik1 E3 ubiquitin ligase complex|Rik1-E3 ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0043494 GO:0043493 biolink:CellularComponent viral terminase complex A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides. go.json phage terminase complex|virus terminase complex http://purl.obolibrary.org/obo/GO_0043493 GO:0043496 biolink:BiologicalProcess regulation of protein homodimerization activity Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. go.json http://purl.obolibrary.org/obo/GO_0043496 gocheck_do_not_annotate GO:0043495 biolink:MolecularActivity protein-membrane adaptor activity The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. go.json anchoring|membrane-membrane adaptor activity|protein membrane adaptor|protein membrane adaptor activity|protein membrane anchor http://purl.obolibrary.org/obo/GO_0043495 GO:0018447 biolink:MolecularActivity chloral hydrate dehydrogenase activity Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol. UM-BBD_enzymeID:e0229 go.json http://purl.obolibrary.org/obo/GO_0018447 GO:0018446 biolink:MolecularActivity pinocarveol dehydrogenase activity Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-. UM-BBD_reactionID:r0717 go.json http://purl.obolibrary.org/obo/GO_0018446 GO:0018449 biolink:MolecularActivity 1-phenylethanol dehydrogenase activity Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2. UM-BBD_reactionID:r0032 go.json http://purl.obolibrary.org/obo/GO_0018449 GO:0018448 biolink:MolecularActivity hydroxymethylmethylsilanediol oxidase activity Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O. UM-BBD_reactionID:r0638 go.json http://purl.obolibrary.org/obo/GO_0018448 GO:0018443 biolink:BiologicalProcess obsolete enzyme active site formation via L-aspartic 4-phosphoric anhydride OBSOLETE. The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride. RESID:AA0033 go.json True http://purl.obolibrary.org/obo/GO_0018443 GO:0018442 biolink:BiologicalProcess obsolete peptidyl-glutamic acid esterification OBSOLETE. The addition of an ester group to a glutamic acid residue in a protein. go.json True http://purl.obolibrary.org/obo/GO_0018442 GO:0018445 biolink:MolecularActivity prothoracicotrophic hormone activity The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects. go.json http://purl.obolibrary.org/obo/GO_0018445 GO:0018444 biolink:CellularComponent translation release factor complex A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome. go.json eukaryotic peptide chain release factor|peptide chain release factor http://purl.obolibrary.org/obo/GO_0018444 GO:0018441 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase. RESID:AA0300 go.json iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide http://purl.obolibrary.org/obo/GO_0018441 gocheck_do_not_annotate GO:0018440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018440 GO:0018458 biolink:MolecularActivity isopiperitenol dehydrogenase activity Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD+ = (6R)-isoperitenone + H+ + NADH. EC:1.1.1.223|KEGG_REACTION:R03261|MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN|RHEA:20860|UM-BBD_reactionID:r0740 go.json (-)-trans-isopiperitenol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018458 GO:0018457 biolink:MolecularActivity perillyl-alcohol dehydrogenase activity Catalysis of the reaction: NAD+ + perillyl alcohol = H+ + NADH + perillyl aldehyde. EC:1.1.1.144|KEGG_REACTION:R03945|MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN|RHEA:10664|UM-BBD_reactionID:r0729 go.json perillyl alcohol dehydrogenase activity|perillyl-alcohol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018457 GO:0018459 biolink:MolecularActivity carveol dehydrogenase activity Catalysis of the reaction: (1S,5R)-carveol + NADP+ = (R)-carvone + H+ + NADPH. EC:1.1.1.243|KEGG_REACTION:R03114|MetaCyc:CARVEOL-DEHYDROGENASE-RXN|RHEA:13629|UM-BBD_reactionID:r0714 go.json (-)-trans-carveol dehydrogenase activity|(-)-trans-carveol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018459 GO:0018454 biolink:MolecularActivity acetoacetyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+. EC:1.1.1.36|RHEA:22256|UM-BBD_reactionID:r0202 go.json (R)-3-hydroxyacyl-CoA dehydrogenase activity|(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity|D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity|D-3-hydroxyacyl-CoA reductase activity|NADP-linked acetoacetyl CoA reductase activity|NADPH:acetoacetyl-CoA reductase activity|acetoacetyl coenzyme A reductase activity|beta-ketoacyl-CoA reductase|hydroxyacyl coenzyme-A dehydrogenase activity|short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity http://purl.obolibrary.org/obo/GO_0018454 GO:0018453 biolink:MolecularActivity 2-hydroxytetrahydrofuran dehydrogenase activity Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone. UM-BBD_reactionID:r0018 go.json http://purl.obolibrary.org/obo/GO_0018453 GO:0018456 biolink:MolecularActivity aryl-alcohol dehydrogenase (NAD+) activity Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+. EC:1.1.1.90|MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN|RHEA:12076|UM-BBD_enzymeID:e0019 go.json aryl-alcohol:NAD+ oxidoreductase activity|benzyl alcohol dehydrogenase activity|p-hydroxybenzyl alcohol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018456 GO:0018455 biolink:MolecularActivity alcohol dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+. EC:1.1.1.71|MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN|RHEA:10736|UM-BBD_reactionID:r0172 go.json alcohol:NAD(P)+ oxidoreductase activity|aldehyde reductase (NADPH/NADH) http://purl.obolibrary.org/obo/GO_0018455 GO:0018450 biolink:MolecularActivity myrtenol dehydrogenase activity Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal. UM-BBD_reactionID:r0710 go.json http://purl.obolibrary.org/obo/GO_0018450 GO:0018452 biolink:MolecularActivity 5-exo-hydroxycamphor dehydrogenase activity Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane. EC:1.1.1.327|MetaCyc:R542-RXN|RHEA:32879|UM-BBD_reactionID:r0427 go.json http://purl.obolibrary.org/obo/GO_0018452 GO:0018451 biolink:MolecularActivity epoxide dehydrogenase activity Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA. UM-BBD_reactionID:r0595 go.json http://purl.obolibrary.org/obo/GO_0018451 GO:0018429 biolink:BiologicalProcess copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide. RESID:AA0298 go.json copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide http://purl.obolibrary.org/obo/GO_0018429 gocheck_do_not_annotate GO:0018428 biolink:BiologicalProcess copper incorporation into copper-sulfur cluster The incorporation of copper into a copper-sulfur cluster. go.json copper incorporation into copper-sulphur cluster http://purl.obolibrary.org/obo/GO_0018428 gocheck_do_not_annotate GO:0018425 biolink:BiologicalProcess O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds. RESID:AA0296 go.json O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism|O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis|O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation|O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis http://purl.obolibrary.org/obo/GO_0018425 gocheck_do_not_annotate GO:0018424 biolink:BiologicalProcess obsolete peptidyl-glutamic acid poly-ADP-ribosylation OBSOLETE. This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way. RESID:AA0295 go.json True http://purl.obolibrary.org/obo/GO_0018424 GO:0018427 biolink:BiologicalProcess copper incorporation into metallo-sulfur cluster The incorporation of copper into a metallo-sulfur cluster. go.json copper incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0018427 gocheck_do_not_annotate GO:0018426 biolink:BiologicalProcess O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage. RESID:AA0297 go.json O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism|O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis|O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation|O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis http://purl.obolibrary.org/obo/GO_0018426 gocheck_do_not_annotate GO:0018421 biolink:MolecularActivity UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0018421 GO:0018420 biolink:BiologicalProcess obsolete peptide cross-linking via N6-(L-isoaspartyl)-L-lysine OBSOLETE. The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues. go.json True http://purl.obolibrary.org/obo/GO_0018420 GO:0018423 biolink:MolecularActivity protein C-terminal leucine carboxyl O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein. Reactome:R-HSA-8856945 go.json protein phosphatase methyltransferase activity|protein-leucine O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0018423 GO:0018422 biolink:MolecularActivity GDP-mannose:serine-protein mannose-1-phosphotransferase activity Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0018422 GO:0018439 biolink:BiologicalProcess obsolete peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine OBSOLETE. The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester. go.json peptidyl-leucine esterification True http://purl.obolibrary.org/obo/GO_0018439 GO:0102111 biolink:MolecularActivity gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 = gibberellin A29 + succinate + carbon dioxide. MetaCyc:RXN-113 go.json http://purl.obolibrary.org/obo/GO_0102111 GO:0102113 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102113 GO:0102115 biolink:MolecularActivity peptidoglycan asparagine synthase activity Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid. MetaCyc:RXN-11338 go.json http://purl.obolibrary.org/obo/GO_0102115 GO:0102114 biolink:MolecularActivity obsolete caprate dehydroxylase activity OBSOLETE. Catalysis of the reaction: decanoate + NADPH + O2 + H+ = 10-hydroxycaprate + NADP + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102114 GO:0102117 biolink:MolecularActivity gibberellin A9 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine = gibberellin A9 methyl ester + S-adenosyl-L-homocysteine. EC:2.1.1.275|MetaCyc:RXN-11358|RHEA:36119 go.json http://purl.obolibrary.org/obo/GO_0102117 GO:0102116 biolink:MolecularActivity obsolete laurate hydroxylase activity OBSOLETE. Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ = 11-hydroxylaurate + NADP + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102116 GO:0102119 biolink:MolecularActivity gibberellin A20 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine. MetaCyc:RXN-11360 go.json http://purl.obolibrary.org/obo/GO_0102119 GO:0102118 biolink:MolecularActivity gibberellin A4 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine = gibberellin A4 methyl ester + S-adenosyl-L-homocysteine. EC:2.1.1.276|MetaCyc:RXN-11359|RHEA:36107 go.json http://purl.obolibrary.org/obo/GO_0102118 GO:0102122 biolink:MolecularActivity gibberellin A34 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine. MetaCyc:RXN-11384|RHEA:36127 go.json http://purl.obolibrary.org/obo/GO_0102122 GO:0102121 biolink:MolecularActivity ceramidase activity Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid. EC:3.5.1.23|MetaCyc:RXN-11375 go.json http://purl.obolibrary.org/obo/GO_0102121 GO:0102124 biolink:MolecularActivity gibberellin A12 16alpha,17 epoxidase activity Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P). MetaCyc:RXN-11387 go.json http://purl.obolibrary.org/obo/GO_0102124 GO:0102123 biolink:MolecularActivity gibberellin A4 16alpha,17 epoxidase activity Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H = 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P). MetaCyc:RXN-11385 go.json http://purl.obolibrary.org/obo/GO_0102123 GO:0102126 biolink:MolecularActivity coniferyl aldehyde 5-hydroxylase activity Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 = 5-hydroxy-coniferaldehyde + NADP + H2O. MetaCyc:RXN-1142 go.json http://purl.obolibrary.org/obo/GO_0102126 GO:0102125 biolink:MolecularActivity gibberellin A9 16alpha,17 epoxidase activity Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P). MetaCyc:RXN-11388 go.json http://purl.obolibrary.org/obo/GO_0102125 GO:0102128 biolink:MolecularActivity chalcone synthase activity Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide. EC:2.3.1.74|MetaCyc:RXN-11468 go.json http://purl.obolibrary.org/obo/GO_0102128 GO:0102127 biolink:MolecularActivity 8-oxoguanine deaminase activity Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O = 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium. EC:3.5.4.32|MetaCyc:RXN-11455|RHEA:32067 go.json http://purl.obolibrary.org/obo/GO_0102127 GO:0102131 biolink:MolecularActivity obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxyglutaryl-[acp] methyl ester = NADPH + H+ + a 3-oxo-glutaryl-[acp] methyl ester. go.json True http://purl.obolibrary.org/obo/GO_0102131 GO:0102130 biolink:MolecularActivity malonyl-CoA methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester. EC:2.1.1.197|MetaCyc:RXN-11475|RHEA:17105 go.json http://purl.obolibrary.org/obo/GO_0102130 GO:0102133 biolink:MolecularActivity limonene hydroxylase activity Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ = (4R)-perillyl alcohol + NAD + H2O. MetaCyc:RXN-11493 go.json http://purl.obolibrary.org/obo/GO_0102133 GO:0102132 biolink:MolecularActivity obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxypimeloyl-[acp] methyl ester = NADPH + H+ + a 3-oxo-pimeloyl-[acp] methyl ester. go.json True http://purl.obolibrary.org/obo/GO_0102132 GO:0102135 biolink:MolecularActivity (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 = (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O. MetaCyc:RXN-11530 go.json http://purl.obolibrary.org/obo/GO_0102135 GO:0102134 biolink:MolecularActivity (22S)-22-hydroxy-campesterol C-23 hydroxylase activity Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 = (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O. MetaCyc:RXN-11529 go.json http://purl.obolibrary.org/obo/GO_0102134 GO:0102137 biolink:MolecularActivity 7-oxateasterone synthase activity Catalysis of the reaction: H+ + teasterone + NADPH + O2 = 7-oxateasterone + NADP + H2O. MetaCyc:RXN-11537 go.json http://purl.obolibrary.org/obo/GO_0102137 GO:0102136 biolink:MolecularActivity 3-epi-6-deoxocathasterone C-23 hydroxylase activity Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O. EC:1.14.14.147|MetaCyc:RXN-11531|RHEA:27321 go.json http://purl.obolibrary.org/obo/GO_0102136 GO:0102139 biolink:MolecularActivity 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate. EC:3.7.1.13|MetaCyc:RXN-11543|RHEA:27870 go.json http://purl.obolibrary.org/obo/GO_0102139 GO:0102138 biolink:MolecularActivity 7-oxatyphasterol synthase activity Catalysis of the reaction: H+ + typhasterol + NADPH + O2 = 7-oxatyphasterol + NADP + H2O. MetaCyc:RXN-11538 go.json http://purl.obolibrary.org/obo/GO_0102138 GO:0102140 biolink:MolecularActivity heparan sulfate N-deacetylase activity Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine. MetaCyc:RXN-11557 go.json http://purl.obolibrary.org/obo/GO_0102140 GO:0102142 biolink:MolecularActivity [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate = adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate. MetaCyc:RXN-11561 go.json http://purl.obolibrary.org/obo/GO_0102142 GO:0102141 biolink:MolecularActivity [chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate. MetaCyc:RXN-11560 go.json http://purl.obolibrary.org/obo/GO_0102141 GO:0102144 biolink:MolecularActivity carboxyspermidine dehydrogenase II activity Catalysis of the reaction: carboxyspermidine + H2O + NADP = L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+. MetaCyc:RXN-11566|RHEA:34111 go.json http://purl.obolibrary.org/obo/GO_0102144 GO:0102143 biolink:MolecularActivity carboxynorspermidine dehydrogenase I activity Catalysis of the reaction: carboxynorspermidine + NADP + H2O = L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+. MetaCyc:RXN-11565|RHEA:34115 go.json http://purl.obolibrary.org/obo/GO_0102143 GO:0102146 biolink:MolecularActivity tricetin O-methytransferase activity Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-11582|RHEA:27493 go.json http://purl.obolibrary.org/obo/GO_0102146 GO:0102145 biolink:MolecularActivity (3R)-(E)-nerolidol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphoric acid. EC:4.2.3.49|MetaCyc:RXN-11575|RHEA:27534 go.json http://purl.obolibrary.org/obo/GO_0102145 GO:0043401 biolink:BiologicalProcess steroid hormone mediated signaling pathway The series of molecular signals mediated by a steroid hormone binding to a receptor. go.json steroid hormone mediated signalling http://purl.obolibrary.org/obo/GO_0043401 GO:0102148 biolink:MolecularActivity N-acetyl-beta-D-galactosaminidase activity Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan. EC:3.2.1.52 go.json http://purl.obolibrary.org/obo/GO_0102148 GO:0102147 biolink:MolecularActivity 3'-O-methyltricetin O methyl transferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin. MetaCyc:RXN-11583|RHEA:27497 go.json http://purl.obolibrary.org/obo/GO_0102147 GO:0043400 biolink:BiologicalProcess cortisol secretion The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. go.json hydrocortisone secretion http://purl.obolibrary.org/obo/GO_0043400 GO:0102149 biolink:MolecularActivity farnesylcysteine lyase activity Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O = (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide. EC:1.8.3.6|MetaCyc:RXN-11623|RHEA:30231 go.json http://purl.obolibrary.org/obo/GO_0102149 GO:0043407 biolink:BiologicalProcess negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. go.json down regulation of MAPK activity|down-regulation of MAPK activity|downregulation of MAPK activity|inhibition of MAPK activity|negative regulation of mitogen activated protein kinase activity|negative regulation of mitogen-activated protein kinase activity http://purl.obolibrary.org/obo/GO_0043407 gocheck_do_not_annotate GO:0043406 biolink:BiologicalProcess positive regulation of MAP kinase activity Any process that activates or increases the frequency, rate or extent of MAP kinase activity. go.json positive regulation of mitogen activated protein kinase activity|positive regulation of mitogen-activated protein kinase activity|stimulation of MAPK activity|up regulation of MAPK activity|up-regulation of MAPK activity|upregulation of MAPK activity http://purl.obolibrary.org/obo/GO_0043406 gocheck_do_not_annotate GO:0043409 biolink:BiologicalProcess negative regulation of MAPK cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. go.json down regulation of MAPK cascade|down regulation of MAPKKK cascade|down-regulation of MAPK cascade|down-regulation of MAPKKK cascade|downregulation of MAPK cascade|downregulation of MAPKKK cascade|inhibition of MAPK cascade|inhibition of MAPKKK cascade|negative regulation of MAP kinase cascade|negative regulation of MAP kinase kinase kinase cascade|negative regulation of MAPKKK cascade|negative regulation of mitogen activated protein kinase cascade|negative regulation of mitogen activated protein kinase kinase kinase cascade|negative regulation of mitogen-activated protein kinase cascade|negative regulation of mitogen-activated protein kinase kinase kinase cascade http://purl.obolibrary.org/obo/GO_0043409 GO:0043408 biolink:BiologicalProcess regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. go.json regulation of MAP kinase cascade|regulation of MAP kinase kinase kinase cascade|regulation of MAPKKK cascade|regulation of mitogen activated protein kinase cascade|regulation of mitogen activated protein kinase kinase kinase cascade|regulation of mitogen-activated protein kinase cascade|regulation of mitogen-activated protein kinase kinase kinase cascade http://purl.obolibrary.org/obo/GO_0043408 GO:0043403 biolink:BiologicalProcess skeletal muscle tissue regeneration The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. go.json myofiber turnover http://purl.obolibrary.org/obo/GO_0043403 GO:0043402 biolink:BiologicalProcess glucocorticoid mediated signaling pathway The series of molecular signals mediated by the detection of a glucocorticoid hormone. go.json glucocorticoid mediated signalling http://purl.obolibrary.org/obo/GO_0043402 GO:0043405 biolink:BiologicalProcess regulation of MAP kinase activity Any process that modulates the frequency, rate or extent of MAP kinase activity. go.json Regulation of MAPK activity|regulation of mitogen activated protein kinase activity|regulation of mitogen-activated protein kinase activity http://purl.obolibrary.org/obo/GO_0043405 gocheck_do_not_annotate GO:0043404 biolink:MolecularActivity corticotropin-releasing hormone receptor activity Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity. go.json CRF receptor activity|CRH receptor activity|adrenocorticotropin-releasing hormone receptor activity|corticotropin-releasing factor receptor activity http://purl.obolibrary.org/obo/GO_0043404 GO:0043410 biolink:BiologicalProcess positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. go.json activation of MAPK cascade|activation of MAPKKK cascade|positive regulation of MAP kinase cascade|positive regulation of MAP kinase kinase kinase cascade|positive regulation of MAPKKK cascade|positive regulation of mitogen activated protein kinase kinase kinase cascade|positive regulation of mitogen-activated protein kinase cascade|positive regulation of mitogen-activated protein kinase kinase kinase cascade|stimulation of MAPK cascade|stimulation of MAPKKK cascade|up regulation of MAPKKK cascade|up-regulation of MAPK cascade|up-regulation of MAPKKK cascade|upregulation of MAPK cascade|upregulation of MAPKKK cascade http://purl.obolibrary.org/obo/GO_0043410 GO:0043412 biolink:BiologicalProcess macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. go.json http://purl.obolibrary.org/obo/GO_0043412 goslim_pir GO:0043411 biolink:MolecularActivity obsolete myopalladin binding OBSOLETE. Binding to myopalladin, a myofibrillar protein with titin-like Ig domains. go.json myopalladin binding True http://purl.obolibrary.org/obo/GO_0043411 GO:0043418 biolink:BiologicalProcess homocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. go.json homocysteine breakdown|homocysteine catabolism|homocysteine degradation http://purl.obolibrary.org/obo/GO_0043418 GO:0043417 biolink:BiologicalProcess negative regulation of skeletal muscle tissue regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration. go.json down regulation of skeletal muscle regeneration|down-regulation of skeletal muscle regeneration|downregulation of skeletal muscle regeneration|inhibition of skeletal muscle regeneration http://purl.obolibrary.org/obo/GO_0043417 GO:0043419 biolink:BiologicalProcess urea catabolic process The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. go.json urea breakdown|urea catabolism|urea decomposition|urea degradation http://purl.obolibrary.org/obo/GO_0043419 GO:0043414 biolink:BiologicalProcess macromolecule methylation The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. go.json http://purl.obolibrary.org/obo/GO_0043414 GO:0043413 biolink:BiologicalProcess macromolecule glycosylation The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. go.json http://purl.obolibrary.org/obo/GO_0043413 GO:0043416 biolink:BiologicalProcess regulation of skeletal muscle tissue regeneration Any process that modulates the frequency, rate or extent of skeletal muscle. go.json http://purl.obolibrary.org/obo/GO_0043416 GO:0043415 biolink:BiologicalProcess positive regulation of skeletal muscle tissue regeneration Any process that activates or increase the rate of skeletal muscle regeneration. go.json activation of skeletal muscle regeneration|stimulation of skeletal muscle regeneration|up regulation of skeletal muscle regeneration|up-regulation of skeletal muscle regeneration|upregulation of skeletal muscle regeneration http://purl.obolibrary.org/obo/GO_0043415 GO:0043421 biolink:BiologicalProcess anthranilate catabolic process The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate). MetaCyc:2AMINOBENZDEG-PWY go.json 2-aminobenzoate breakdown|2-aminobenzoate catabolic process|2-aminobenzoate catabolism|2-aminobenzoate degradation|anthranilate breakdown|anthranilate catabolism|anthranilate degradation|anthranilic acid catabolic process|anthranilic acid catabolism|ortho-aminobenzoic acid catabolic process|ortho-aminobenzoic acid catabolism http://purl.obolibrary.org/obo/GO_0043421 GO:0043420 biolink:BiologicalProcess anthranilate metabolic process The chemical reactions and pathways involving anthranilate (2-aminobenzoate). UM-BBD_pathwayID:abz2 go.json 2-aminobenzoate metabolic process|2-aminobenzoate metabolism|anthranilate metabolism|anthranilic acid metabolic process|anthranilic acid metabolism|ortho-aminobenzoic acid metabolic process|ortho-aminobenzoic acid metabolism http://purl.obolibrary.org/obo/GO_0043420 GO:0043423 biolink:MolecularActivity 3-phosphoinositide-dependent protein kinase binding Binding to a 3-phosphoinositide-dependent protein kinase. go.json phosphatidylinositol-3-phosphate-dependent protein kinase binding http://purl.obolibrary.org/obo/GO_0043423 GO:0043422 biolink:MolecularActivity protein kinase B binding Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. go.json Akt binding|PKB binding http://purl.obolibrary.org/obo/GO_0043422 GO:0043429 biolink:MolecularActivity 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. go.json 2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity http://purl.obolibrary.org/obo/GO_0043429 GO:0043428 biolink:MolecularActivity 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MetaCyc:RXN-9227|RHEA:44756 go.json 2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity http://purl.obolibrary.org/obo/GO_0043428 GO:0043425 biolink:MolecularActivity bHLH transcription factor binding Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. go.json http://purl.obolibrary.org/obo/GO_0043425 GO:0043424 biolink:MolecularActivity protein histidine kinase binding Binding to a protein histidine kinase. go.json histidine kinase binding|histidine-protein kinase binding|protein-histidine kinase binding http://purl.obolibrary.org/obo/GO_0043424 GO:0043427 biolink:BiologicalProcess carbon fixation by 3-hydroxypropionate cycle An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product. go.json 3-hydroxypropionate cycle|3-hydroxypropionate pathway|hydroxypropionate cycle|hydroxypropionate pathway http://purl.obolibrary.org/obo/GO_0043427 GO:0043426 biolink:MolecularActivity MRF binding Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. go.json Mrf4 binding|Myf5 binding|MyoD binding|myogenin binding http://purl.obolibrary.org/obo/GO_0043426 GO:0043432 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043432 GO:0043431 biolink:MolecularActivity 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine. MetaCyc:2.1.1.64-RXN go.json 2-octaprenyl-6-hydroxy phenol methylase activity|3-demethylubiquinone-9 3-methyltransferase activity http://purl.obolibrary.org/obo/GO_0043431 GO:0043434 biolink:BiologicalProcess response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. go.json response to peptide hormone stimulus|response to polypeptide hormone stimulus http://purl.obolibrary.org/obo/GO_0043434 GO:0043433 biolink:BiologicalProcess negative regulation of DNA-binding transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. go.json down regulation of transcription factor activity|down-regulation of transcription factor activity|downregulation of transcription factor activity|inhibition of transcription factor activity|negative regulation of DNA binding transcription factor activity|negative regulation of androgen receptor activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of thyroid hormone receptor activity|negative regulation of transcription factor activity http://purl.obolibrary.org/obo/GO_0043433 gocheck_do_not_annotate GO:0043430 biolink:MolecularActivity 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. RHEA:44764|Reactome:R-HSA-2162188 go.json 2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity http://purl.obolibrary.org/obo/GO_0043430 GO:0043439 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043439 GO:0043436 biolink:BiologicalProcess oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). go.json keto acid metabolic process|keto acid metabolism|ketoacid metabolic process|ketoacid metabolism|oxo acid metabolic process|oxo acid metabolism|oxoacid metabolism http://purl.obolibrary.org/obo/GO_0043436 GO:0043435 biolink:BiologicalProcess response to corticotropin-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. go.json response to CRF stimulus|response to CRH stimulus|response to corticoliberin stimulus|response to corticotropin-releasing factor stimulus|response to corticotropin-releasing hormone stimulus http://purl.obolibrary.org/obo/GO_0043435 GO:0043438 biolink:BiologicalProcess acetoacetic acid metabolic process The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH. go.json 3-oxobutanoate metabolic process|3-oxobutanoate metabolism|3-oxobutanoic acid metabolic process|3-oxobutanoic acid metabolism|acetoacetate metabolic process|acetoacetate metabolism|acetoacetic acid metabolism|beta ketobutyric acid metabolic process|beta ketobutyric acid metabolism|beta-ketobutyric acid metabolic process|beta-ketobutyric acid metabolism|diacetic acid metabolic process|diacetic acid metabolism http://purl.obolibrary.org/obo/GO_0043438 GO:0043437 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043437 GO:0102100 biolink:MolecularActivity mycothiol-arsenate ligase activity Catalysis of the reaction: arsenate + mycothiol = mycothiol-arsenate conjugate + H2O. EC:2.8.4.2|MetaCyc:RXN-11187|RHEA:27349 go.json http://purl.obolibrary.org/obo/GO_0102100 GO:0102102 biolink:MolecularActivity homocarnosine synthase activity Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate. EC:6.3.2.11|MetaCyc:RXN-11222|RHEA:59568 go.json http://purl.obolibrary.org/obo/GO_0102102 GO:0043443 biolink:BiologicalProcess obsolete acetone metabolic process OBSOLETE. The chemical reactions and pathways involving acetone, propan-2-one. go.json 2-propanone metabolic process|2-propanone metabolism|acetone metabolism|dimethyl ketone metabolic process|dimethyl ketone metabolism|propan-2-one metabolic process|propan-2-one metabolism True http://purl.obolibrary.org/obo/GO_0043443 GO:0043442 biolink:BiologicalProcess acetoacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. go.json acetoacetic acid breakdown|acetoacetic acid catabolism|acetoacetic acid degradation http://purl.obolibrary.org/obo/GO_0043442 GO:0102101 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102101 GO:0043445 biolink:BiologicalProcess obsolete acetone biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of acetone, propan-2-one. go.json 2-propanone biosynthesis|2-propanone biosynthetic process|acetone anabolism|acetone biosynthesis|acetone formation|acetone synthesis|dimethyl ketone biosynthesis|dimethyl ketone biosynthetic process|propan-2-one biosynthesis|propan-2-one biosynthetic process True http://purl.obolibrary.org/obo/GO_0043445 GO:0102104 biolink:MolecularActivity demethoxycurcumin synthase activity Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide. MetaCyc:RXN-11224 go.json http://purl.obolibrary.org/obo/GO_0102104 GO:0043444 biolink:BiologicalProcess obsolete acetone catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one. go.json 2-propanone catabolic process|2-propanone catabolism|acetone breakdown|acetone catabolism|acetone degradation|dimethyl ketone catabolic process|dimethyl ketone catabolism|propan-2-one catabolic process|propan-2-one catabolism True http://purl.obolibrary.org/obo/GO_0043444 GO:0102103 biolink:MolecularActivity demethoxycurcumin synthase Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O = bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide. EC:2.3.1.219|MetaCyc:RXN-11223|RHEA:35119 go.json http://purl.obolibrary.org/obo/GO_0102103 GO:0102106 biolink:MolecularActivity curcumin synthase activity Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O = curcumin + 2 coenzyme A(4-) + carbon dioxide. EC:2.3.1.217|MetaCyc:RXN-11226|RHEA:34823 go.json http://purl.obolibrary.org/obo/GO_0102106 GO:0102105 biolink:MolecularActivity demethoxycurcumin synthase activity from feruloylacetyl-CoA Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide. EC:2.3.1.219|MetaCyc:RXN-11225|RHEA:35139 go.json http://purl.obolibrary.org/obo/GO_0102105 GO:0043441 biolink:BiologicalProcess acetoacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. go.json acetoacetic acid anabolism|acetoacetic acid biosynthesis|acetoacetic acid formation|acetoacetic acid synthesis http://purl.obolibrary.org/obo/GO_0043441 GO:0043440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043440 GO:0102109 biolink:MolecularActivity tricaffeoyl spermidine O-methyltransferase activity Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine = 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine. MetaCyc:RXN-11261 go.json http://purl.obolibrary.org/obo/GO_0102109 GO:0043447 biolink:BiologicalProcess alkane biosynthetic process The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2. go.json alkane anabolism|alkane biosynthesis|alkane formation|alkane synthesis http://purl.obolibrary.org/obo/GO_0043447 GO:0043446 biolink:BiologicalProcess cellular alkane metabolic process The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells. go.json alkane metabolism http://purl.obolibrary.org/obo/GO_0043446 goslim_pir GO:0043449 biolink:BiologicalProcess cellular alkene metabolic process The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells. go.json alkene metabolism http://purl.obolibrary.org/obo/GO_0043449 goslim_pir GO:0043448 biolink:BiologicalProcess alkane catabolic process The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2. go.json alkane breakdown|alkane catabolism|alkane degradation http://purl.obolibrary.org/obo/GO_0043448 GO:0102193 biolink:MolecularActivity protein-ribulosamine 3-kinase activity Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine = ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine. EC:2.7.1.172|MetaCyc:RXN-12003|RHEA:48432 go.json http://purl.obolibrary.org/obo/GO_0102193 GO:0102192 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102192 GO:0102195 biolink:MolecularActivity UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP = UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+. EC:6.3.2.37|MetaCyc:RXN-12042|RHEA:25273 go.json http://purl.obolibrary.org/obo/GO_0102195 GO:0102194 biolink:MolecularActivity protein-fructosamine 3-kinase activity Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine = ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine. EC:2.7.1.171|MetaCyc:RXN-12005|RHEA:59832 go.json fructosamine-3-kinase activity http://purl.obolibrary.org/obo/GO_0102194 GO:0102197 biolink:MolecularActivity vinylacetate caboxylester hydrolase activity Catalysis of the reaction: but-3-enoate + H2O = allyl alcohol + formate. MetaCyc:RXN-12087 go.json http://purl.obolibrary.org/obo/GO_0102197 GO:0102196 biolink:MolecularActivity cortisol dehydrogenase activity Catalysis of the reaction: cortisol + NADP = cortisone + NADPH + H+. EC:1.1.1.146|MetaCyc:RXN-12085|RHEA:68616 go.json http://purl.obolibrary.org/obo/GO_0102196 GO:0102199 biolink:MolecularActivity nitric oxide reductase activity (NAD(P)H-dependent) activity Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H. EC:1.7.1.14|MetaCyc:RXN-12112 go.json http://purl.obolibrary.org/obo/GO_0102199 GO:0102198 biolink:MolecularActivity L-idonate 5-dehydrogenase activity (NAD-dependent) Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+. EC:1.1.1.366|MetaCyc:RXN-12107|RHEA:21172 go.json http://purl.obolibrary.org/obo/GO_0102198 GO:0102151 biolink:MolecularActivity 3-oxo-myristate decarboxylase activity Catalysis of the reaction: 3-oxo-myristate + H+ = 2-tridecanone + carbon dioxide. EC:4.1.1.56|MetaCyc:RXN-11669 go.json http://purl.obolibrary.org/obo/GO_0102151 GO:0102150 biolink:MolecularActivity 3-oxo-myristoyl-CoA hydrolase activity Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O = 3-oxo-myristate + coenzyme A + H+. MetaCyc:RXN-11668 go.json http://purl.obolibrary.org/obo/GO_0102150 GO:0102152 biolink:MolecularActivity Delta12-linoleate epoxygenase activity Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 = 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O. MetaCyc:RXN-11671 go.json http://purl.obolibrary.org/obo/GO_0102152 GO:0102155 biolink:MolecularActivity S-sulfolactate dehydrogenase activity Catalysis of the reaction: (S)-3-sulfonatolactate + NAD = 3-sulfonatopyruvate(2-) + NADH + H+. EC:1.1.1.310|MetaCyc:RXN-11689|RHEA:28194 go.json http://purl.obolibrary.org/obo/GO_0102155 GO:0102154 biolink:MolecularActivity 8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+. MetaCyc:RXN-11685 go.json http://purl.obolibrary.org/obo/GO_0102154 GO:0102157 biolink:MolecularActivity (R)-sulfopropanediol 2-dehydrogenase activity Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD = 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+. MetaCyc:RXN-11729 go.json http://purl.obolibrary.org/obo/GO_0102157 GO:0102156 biolink:MolecularActivity 2,5-DHBA UDP-glucosyltransferase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose = 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+. MetaCyc:RXN-11705 go.json http://purl.obolibrary.org/obo/GO_0102156 GO:0102159 biolink:MolecularActivity baicalein 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein = H+ + UDP + baicalin. EC:2.4.1.253|MetaCyc:RXN-11755|RHEA:28314 go.json http://purl.obolibrary.org/obo/GO_0102159 GO:0102158 biolink:MolecularActivity very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. EC:4.2.1.134|MetaCyc:RXN-11750|RHEA:45812 go.json very-long-chain 3-hydroxyacyl-CoA dehydratase activity http://purl.obolibrary.org/obo/GO_0102158 GO:0102160 biolink:MolecularActivity cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate = H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP. EC:2.4.1.254|MetaCyc:RXN-11756|RHEA:28258 go.json http://purl.obolibrary.org/obo/GO_0102160 GO:0102162 biolink:MolecularActivity all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 = all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial. EC:1.13.11.75|MetaCyc:RXN-11783|RHEA:26385 go.json http://purl.obolibrary.org/obo/GO_0102162 GO:0102161 biolink:MolecularActivity copal-8-ol diphosphate synthase activity Catalysis of the reaction: copal-8-ol diphosphate = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O. EC:4.2.1.133|MetaCyc:RXN-11772|RHEA:32703 go.json http://purl.obolibrary.org/obo/GO_0102161 GO:0102164 biolink:MolecularActivity 2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ = 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O. EC:1.14.13.182|MetaCyc:RXN-11849|RHEA:37871 go.json http://purl.obolibrary.org/obo/GO_0102164 GO:0102163 biolink:MolecularActivity 3-hydroxyacyl-CoA-acyl carrier protein transferase activity Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]. MetaCyc:RXN-11785 go.json http://purl.obolibrary.org/obo/GO_0102163 GO:0102166 biolink:MolecularActivity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine. EC:3.2.1.169|MetaCyc:RXN-11891|RHEA:48892 go.json http://purl.obolibrary.org/obo/GO_0102166 GO:0102165 biolink:MolecularActivity (Z)-3-hexen-1-ol acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol = (3Z)-hex-3-en-1-yl acetate + coenzyme A. EC:2.3.1.195|MetaCyc:RXN-11852|RHEA:28254 go.json http://purl.obolibrary.org/obo/GO_0102165 GO:0102168 biolink:MolecularActivity 5-methyl-phenazine-1-carboxylate N-methyltransferase activity Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine. MetaCyc:RXN-11897|RHEA:49112 go.json http://purl.obolibrary.org/obo/GO_0102168 GO:0102167 biolink:MolecularActivity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine. EC:3.2.1.169|MetaCyc:RXN-11892|RHEA:48876 go.json http://purl.obolibrary.org/obo/GO_0102167 GO:0102169 biolink:MolecularActivity pyocyanin hydroxylase activity Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ = pyocyanin + NAD + carbon dioxide + H2O. EC:1.14.13.218|MetaCyc:RXN-11898|RHEA:48976 go.json http://purl.obolibrary.org/obo/GO_0102169 GO:0102171 biolink:MolecularActivity DMNT synthase activity Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 = (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O. MetaCyc:RXN-11911|RHEA:55424 go.json http://purl.obolibrary.org/obo/GO_0102171 GO:0102170 biolink:MolecularActivity 5-epi-aristolochene-1,3-dihydroxylase activity Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 = capsidiol + 2 NADP + 2 H2O. EC:1.14.14.149|MetaCyc:RXN-11908|RHEA:28226 go.json http://purl.obolibrary.org/obo/GO_0102170 GO:0102173 biolink:MolecularActivity 24-methylenecycloartanol 4alpha-methyl oxidase activity Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O. MetaCyc:RXN-11926|RHEA:58836 go.json http://purl.obolibrary.org/obo/GO_0102173 GO:0102172 biolink:MolecularActivity 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O. MetaCyc:RXN-11925|RHEA:58860 go.json http://purl.obolibrary.org/obo/GO_0102172 GO:0102175 biolink:MolecularActivity 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH. MetaCyc:RXN-11928|RHEA:34775 go.json http://purl.obolibrary.org/obo/GO_0102175 GO:0102174 biolink:MolecularActivity 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O. MetaCyc:RXN-11927|RHEA:58864 go.json http://purl.obolibrary.org/obo/GO_0102174 GO:0102177 biolink:MolecularActivity 24-methylenelophenol methyl oxidase activity Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ = 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. EC:1.14.18.11|MetaCyc:RXN-11930|RHEA:58872 go.json http://purl.obolibrary.org/obo/GO_0102177 GO:0102176 biolink:MolecularActivity obsolete cycloeucalenone reductase activity OBSOLETE. Catalysis of the reaction: cycloeucalenone + NADPH + H+ = cycloeucalenol + NADP. go.json True http://purl.obolibrary.org/obo/GO_0102176 GO:0102179 biolink:MolecularActivity 24-ethylidenelophenol 4alpha-methyl oxidase activity Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ = 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O. MetaCyc:RXN-11935|RHEA:59032 go.json http://purl.obolibrary.org/obo/GO_0102179 GO:0102178 biolink:MolecularActivity 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH = 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. MetaCyc:RXN-11932|RHEA:58880 go.json http://purl.obolibrary.org/obo/GO_0102178 GO:0102180 biolink:MolecularActivity 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ = 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O. MetaCyc:RXN-11936|RHEA:59036 go.json http://purl.obolibrary.org/obo/GO_0102180 GO:0102182 biolink:MolecularActivity 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD = avenastenone + NADH + carbon dioxide. MetaCyc:RXN-11938 go.json http://purl.obolibrary.org/obo/GO_0102182 GO:0102181 biolink:MolecularActivity 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 = 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O. MetaCyc:RXN-11937|RHEA:59040 go.json http://purl.obolibrary.org/obo/GO_0102181 GO:0102184 biolink:MolecularActivity cycloartenol 4alpha-methyl oxidase activity Catalysis of the reaction: cycloartenol + NADH + O2 + H+ = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O. MetaCyc:RXN-11946 go.json http://purl.obolibrary.org/obo/GO_0102184 GO:0102183 biolink:MolecularActivity obsolete avenastenone reductase activity OBSOLETE. Catalysis of the reaction: avenastenone + NADPH + H+ = avenasterol + NADP. go.json True http://purl.obolibrary.org/obo/GO_0102183 GO:0102186 biolink:MolecularActivity 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 = 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O. MetaCyc:RXN-11948 go.json http://purl.obolibrary.org/obo/GO_0102186 GO:0102185 biolink:MolecularActivity 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O. MetaCyc:RXN-11947 go.json http://purl.obolibrary.org/obo/GO_0102185 GO:0102188 biolink:MolecularActivity 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ = 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O. MetaCyc:RXN-11956 go.json http://purl.obolibrary.org/obo/GO_0102188 GO:0102187 biolink:MolecularActivity obsolete 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity OBSOLETE. Catalysis of the reaction: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) = 4alpha,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3-one + NADH(2-) + carbon dioxide. go.json True http://purl.obolibrary.org/obo/GO_0102187 GO:0102189 biolink:MolecularActivity obsolete 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity OBSOLETE. Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ = 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O. MetaCyc:RXN-11957 go.json True http://purl.obolibrary.org/obo/GO_0102189 GO:0102191 biolink:MolecularActivity 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) = 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide. EC:1.1.1.418|MetaCyc:RXN-11959|RHEA:59016 go.json http://purl.obolibrary.org/obo/GO_0102191 GO:0102190 biolink:MolecularActivity 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) = 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O. MetaCyc:RXN-11958 go.json http://purl.obolibrary.org/obo/GO_0102190 GO:0018407 biolink:BiologicalProcess obsolete peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine OBSOLETE. The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine). RESID:AA0177 go.json peptidyl-thyronine iodination to form triiodothyronine True http://purl.obolibrary.org/obo/GO_0018407 GO:0018406 biolink:BiologicalProcess protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring. RESID:AA0217 go.json protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|protein amino acid C-linked mannosylation http://purl.obolibrary.org/obo/GO_0018406 gocheck_do_not_annotate GO:0018409 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018409 GO:0018408 biolink:BiologicalProcess obsolete peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine OBSOLETE. The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine). RESID:AA0178 go.json True http://purl.obolibrary.org/obo/GO_0018408 GO:0018403 biolink:BiologicalProcess protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. RESID:AA0209 go.json protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine http://purl.obolibrary.org/obo/GO_0018403 gocheck_do_not_annotate GO:0018402 biolink:BiologicalProcess protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. RESID:AA0208 go.json protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine http://purl.obolibrary.org/obo/GO_0018402 gocheck_do_not_annotate GO:0018405 biolink:BiologicalProcess protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues. RESID:AA0247 go.json protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine http://purl.obolibrary.org/obo/GO_0018405 gocheck_do_not_annotate GO:0018404 biolink:BiologicalProcess protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. RESID:AA0210 go.json protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine http://purl.obolibrary.org/obo/GO_0018404 gocheck_do_not_annotate GO:0018401 biolink:BiologicalProcess peptidyl-proline hydroxylation to 4-hydroxy-L-proline The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. RESID:AA0030 go.json http://purl.obolibrary.org/obo/GO_0018401 gocheck_do_not_annotate GO:0018400 biolink:BiologicalProcess peptidyl-proline hydroxylation to 3-hydroxy-L-proline The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase. RESID:AA0029 go.json http://purl.obolibrary.org/obo/GO_0018400 gocheck_do_not_annotate GO:0018418 biolink:BiologicalProcess nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. RESID:AA0293 go.json nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide http://purl.obolibrary.org/obo/GO_0018418 gocheck_do_not_annotate GO:0018417 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. RESID:AA0293 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide http://purl.obolibrary.org/obo/GO_0018417 gocheck_do_not_annotate GO:0018419 biolink:BiologicalProcess protein catenane formation The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain. go.json http://purl.obolibrary.org/obo/GO_0018419 GO:0018414 biolink:BiologicalProcess nickel incorporation into metallo-sulfur cluster The incorporation of nickel into a metallo-sulfur cluster. go.json nickel incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0018414 gocheck_do_not_annotate GO:0018413 biolink:BiologicalProcess peptidyl-serine O-glucuronidation The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine. RESID:AA0291 go.json http://purl.obolibrary.org/obo/GO_0018413 gocheck_do_not_annotate GO:0018416 biolink:BiologicalProcess nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. RESID:AA0292 go.json nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide http://purl.obolibrary.org/obo/GO_0018416 gocheck_do_not_annotate GO:0018415 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. RESID:AA0292 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide http://purl.obolibrary.org/obo/GO_0018415 gocheck_do_not_annotate GO:0018410 biolink:BiologicalProcess C-terminal protein amino acid modification The alteration of the C-terminal amino acid residue in a protein. go.json peptide or protein carboxyl-terminal blocking|peptide/protein carboxyl-terminal blocking http://purl.obolibrary.org/obo/GO_0018410 gocheck_do_not_annotate GO:0018412 biolink:BiologicalProcess protein O-glucuronidation The modification of a protein by glucuronidation on an amino acid oxygen atom. go.json protein amino acid O-glucuronidation http://purl.obolibrary.org/obo/GO_0018412 gocheck_do_not_annotate GO:0018411 biolink:BiologicalProcess protein glucuronidation The modification of a protein by amino acid glucuronidation. go.json protein amino acid glucuronidation http://purl.obolibrary.org/obo/GO_0018411 gocheck_do_not_annotate GO:0043575 biolink:BiologicalProcess detection of osmotic stimulus The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0043575 GO:0043574 biolink:BiologicalProcess peroxisomal transport Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. go.json http://purl.obolibrary.org/obo/GO_0043574 GO:0043577 biolink:BiologicalProcess chemotropism The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it. Wikipedia:Chemotropism go.json http://purl.obolibrary.org/obo/GO_0043577 GO:0043576 biolink:BiologicalProcess regulation of respiratory gaseous exchange Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. go.json http://purl.obolibrary.org/obo/GO_0043576 GO:0043571 biolink:BiologicalProcess maintenance of CRISPR repeat elements Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. go.json CRISPR element metabolic process|CRISPR element metabolism|maintenance of clustered regularly interspaced short palindromic repeat elements http://purl.obolibrary.org/obo/GO_0043571 GO:0043570 biolink:BiologicalProcess maintenance of DNA repeat elements Any process involved in sustaining the fidelity and copy number of DNA repeat elements. go.json http://purl.obolibrary.org/obo/GO_0043570 GO:0043573 biolink:BiologicalProcess leucoplast fission The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes. go.json http://purl.obolibrary.org/obo/GO_0043573 GO:0043572 biolink:BiologicalProcess plastid fission The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. go.json http://purl.obolibrary.org/obo/GO_0043572 GO:0043579 biolink:BiologicalProcess elaioplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored. go.json elaioplast organisation|elaioplast organization and biogenesis http://purl.obolibrary.org/obo/GO_0043579 GO:0043578 biolink:BiologicalProcess nuclear matrix organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane. go.json nuclear matrix organisation|nuclear matrix organization and biogenesis|nucleoskeleton organization http://purl.obolibrary.org/obo/GO_0043578 GO:0043580 biolink:BiologicalProcess periplasmic space organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi. go.json periplasmic space organisation|periplasmic space organization and biogenesis http://purl.obolibrary.org/obo/GO_0043580 GO:0043586 biolink:BiologicalProcess tongue development The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. go.json glossa development|lingua development http://purl.obolibrary.org/obo/GO_0043586 GO:0043585 biolink:BiologicalProcess nose morphogenesis The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). go.json nasus morphogenesis http://purl.obolibrary.org/obo/GO_0043585 GO:0043588 biolink:BiologicalProcess skin development The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. go.json animal skin development http://purl.obolibrary.org/obo/GO_0043588 GO:0102400 biolink:MolecularActivity dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+. MetaCyc:RXN-13667 go.json http://purl.obolibrary.org/obo/GO_0102400 GO:0043587 biolink:BiologicalProcess tongue morphogenesis The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. go.json glossa morphogenesis|lingua morphogenesis http://purl.obolibrary.org/obo/GO_0043587 GO:0043582 biolink:BiologicalProcess sporangium development The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores. go.json sporangia development http://purl.obolibrary.org/obo/GO_0043582 GO:0043581 biolink:BiologicalProcess obsolete mycelium development OBSOLETE. The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae. go.json True http://purl.obolibrary.org/obo/GO_0043581 GO:0102402 biolink:MolecularActivity 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose. EC:3.2.1.149|MetaCyc:RXN-13694 go.json http://purl.obolibrary.org/obo/GO_0102402 GO:0043584 biolink:BiologicalProcess nose development The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). go.json nasus development http://purl.obolibrary.org/obo/GO_0043584 GO:0102405 biolink:MolecularActivity (+)-taxifolin 5'-hydroxylase activity Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ = (+)-dihydromyricetin + NADP(3-) + H2O. MetaCyc:RXN-13718|RHEA:61116 go.json http://purl.obolibrary.org/obo/GO_0102405 GO:0102404 biolink:MolecularActivity linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O = vicianose + linalool. EC:3.2.1.149|MetaCyc:RXN-13701 go.json http://purl.obolibrary.org/obo/GO_0102404 GO:0043583 biolink:BiologicalProcess ear development The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. go.json hearing organ development http://purl.obolibrary.org/obo/GO_0043583 GO:0102407 biolink:MolecularActivity obsolete sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity OBSOLETE. Catalysis of the reaction: C22:0-DCA-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-C22:0-DCA-LPA. go.json True http://purl.obolibrary.org/obo/GO_0102407 GO:0102406 biolink:MolecularActivity omega-hydroxypalmitate O-sinapoyl transferase activity Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate = coenzyme A + 16-sinapoyloxypalmitate. EC:2.3.1.188|MetaCyc:RXN-13728|RHEA:26470 go.json http://purl.obolibrary.org/obo/GO_0102406 GO:0102409 biolink:MolecularActivity obsolete sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity OBSOLETE. Catalysis of the reaction: behenoyl-CoA + sn-glycerol 3-phosphate(2-) = coenzyme A + 2-docosanoyl-glycerol 3-phosphate. go.json True http://purl.obolibrary.org/obo/GO_0102409 GO:0102408 biolink:MolecularActivity obsolete sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity OBSOLETE. Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + sn-2-C16:0-DCA-LPA. go.json True http://purl.obolibrary.org/obo/GO_0102408 GO:0043589 biolink:BiologicalProcess skin morphogenesis The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. go.json http://purl.obolibrary.org/obo/GO_0043589 GO:0018591 biolink:MolecularActivity methyl tertiary butyl ether 3-monooxygenase activity Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde. go.json MTBE 3-monooxygenase activity http://purl.obolibrary.org/obo/GO_0018591 GO:0043591 biolink:CellularComponent endospore external encapsulating structure The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer. go.json endospore wall|peptidoglycan-based spore wall|spore wall http://purl.obolibrary.org/obo/GO_0043591 goslim_pir GO:0018590 biolink:MolecularActivity methylsilanetriol hydroxylase activity Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol. UM-BBD_reactionID:r0640 go.json http://purl.obolibrary.org/obo/GO_0018590 GO:0043590 biolink:CellularComponent bacterial nucleoid The region of a bacterial cell to which the DNA is confined. go.json http://purl.obolibrary.org/obo/GO_0043590 prokaryote_subset GO:0043597 biolink:CellularComponent cytoplasmic replication fork The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. go.json http://purl.obolibrary.org/obo/GO_0043597 GO:0102410 biolink:MolecularActivity quercetin-4',3-O-glucosyltransferase activity Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-). MetaCyc:RXN-13765 go.json http://purl.obolibrary.org/obo/GO_0102410 GO:0043596 biolink:CellularComponent nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. go.json http://purl.obolibrary.org/obo/GO_0043596 GO:0043599 biolink:CellularComponent nuclear DNA replication factor C complex A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species. go.json nuclear RFC http://purl.obolibrary.org/obo/GO_0043599 GO:0102412 biolink:MolecularActivity valerena-4,7(11)-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = valerena-4,7(11)-diene + diphosphoric acid. EC:4.2.3.139|MetaCyc:RXN-13769|RHEA:34467 go.json http://purl.obolibrary.org/obo/GO_0102412 GO:0102411 biolink:MolecularActivity quercetin-3,4'-O-glucosyltransferase activity Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-). MetaCyc:RXN-13766 go.json http://purl.obolibrary.org/obo/GO_0102411 GO:0043598 biolink:CellularComponent cytoplasmic DNA replication factor C complex A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species. go.json cytoplasmic RFC|cytoplasmic clamp loader http://purl.obolibrary.org/obo/GO_0043598 GO:0102414 biolink:MolecularActivity quercetin-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin-3-gentiobioside + UDP. MetaCyc:RXN-13797 go.json http://purl.obolibrary.org/obo/GO_0102414 GO:0043593 biolink:CellularComponent endospore coat The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination. go.json http://purl.obolibrary.org/obo/GO_0043593 GO:0043592 biolink:CellularComponent exosporium The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid. go.json epispore|exospore|perispore http://purl.obolibrary.org/obo/GO_0043592 GO:0102413 biolink:MolecularActivity 6-O-methyl-deacetylisoipecoside beta-glucosidase activity Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O = 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose. MetaCyc:RXN-13791 go.json http://purl.obolibrary.org/obo/GO_0102413 GO:0043595 biolink:CellularComponent endospore cortex A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0043595 GO:0102416 biolink:MolecularActivity quercetin gentiotrioside 1,6-glucosyltransferase activity Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose = quercetin-3-gentiotetraside + UDP + H+. MetaCyc:RXN-13799 go.json http://purl.obolibrary.org/obo/GO_0102416 GO:0043594 biolink:CellularComponent outer endospore membrane The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat. go.json http://purl.obolibrary.org/obo/GO_0043594 GO:0102415 biolink:MolecularActivity quercetin gentiobioside 1,6-glucosyltransferase activity Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose = quercetin-3-gentiotrioside + UDP + H+. MetaCyc:RXN-13798 go.json http://purl.obolibrary.org/obo/GO_0102415 GO:0102418 biolink:MolecularActivity luteolin-7-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+. MetaCyc:RXN-13801 go.json http://purl.obolibrary.org/obo/GO_0102418 GO:0102417 biolink:MolecularActivity apigenin-7-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = apigenin-7-O-gentiobioside + UDP + H+. MetaCyc:RXN-13800 go.json http://purl.obolibrary.org/obo/GO_0102417 GO:0102419 biolink:MolecularActivity obsolete sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity OBSOLETE. Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA. go.json True http://purl.obolibrary.org/obo/GO_0102419 GO:0018589 biolink:MolecularActivity di-n-butyltin dioxygenase activity Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin. UM-BBD_reactionID:r0645 go.json DBT dioxygenase activity http://purl.obolibrary.org/obo/GO_0018589 GO:0018586 biolink:MolecularActivity mono-butyltin dioxygenase activity Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin. UM-BBD_reactionID:r0647 go.json MBT dioxygenase activity http://purl.obolibrary.org/obo/GO_0018586 GO:0018585 biolink:MolecularActivity fluorene oxygenase activity Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol. UM-BBD_reactionID:r0407 go.json http://purl.obolibrary.org/obo/GO_0018585 GO:0018588 biolink:MolecularActivity tri-n-butyltin dioxygenase activity Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin. UM-BBD_reactionID:r0643 go.json TBT dioxygenase activity http://purl.obolibrary.org/obo/GO_0018588 GO:0018587 biolink:MolecularActivity obsolete limonene 8-monooxygenase activity OBSOLETE. (Was not defined before being made obsolete). go.json limonene 8-monooxygenase activity True http://purl.obolibrary.org/obo/GO_0018587 GO:0018582 biolink:MolecularActivity 1-hydroxy-2-naphthoate 1,2-dioxygenase activity Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate. EC:1.13.11.38|MetaCyc:1.13.11.38-RXN|RHEA:14749|UM-BBD_reactionID:r0486 go.json 1-hydroxy-2-naphthoate dioxygenase activity|1-hydroxy-2-naphthoate-degrading enzyme activity|1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)|1-hydroxy-2-naphthoic acid dioxygenase activity http://purl.obolibrary.org/obo/GO_0018582 GO:0018581 biolink:MolecularActivity hydroxyquinol 1,2-dioxygenase activity Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+). EC:1.13.11.37|MetaCyc:RXN-17556|RHEA:19441|UM-BBD_reactionID:r0232 go.json http://purl.obolibrary.org/obo/GO_0018581 GO:0018584 biolink:MolecularActivity 2,4,5-trichlorophenoxyacetic acid oxygenase activity Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol. EC:1.13.99.-|UM-BBD_reactionID:r0359 go.json http://purl.obolibrary.org/obo/GO_0018584 GO:0018583 biolink:MolecularActivity biphenyl-2,3-diol 1,2-dioxygenase activity Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O. EC:1.13.11.39|MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN|RHEA:14413|UM-BBD_enzymeID:e0127 go.json 2,3-dihydroxybiphenyl 1,2-dioxygenase activity|2,3-dihydroxybiphenyl dioxygenase activity|biphenyl-2,3-diol dioxygenase activity|biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing) http://purl.obolibrary.org/obo/GO_0018583 GO:0102421 biolink:MolecularActivity curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotrioside + UDP + H+. MetaCyc:RXN-13813 go.json http://purl.obolibrary.org/obo/GO_0102421 GO:0102420 biolink:MolecularActivity sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate. EC:2.3.1.15|MetaCyc:RXN-13805 go.json http://purl.obolibrary.org/obo/GO_0102420 GO:0102423 biolink:MolecularActivity (+)-sesaminol 2-O-glucosyltransferase activity Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+. MetaCyc:RXN-13818 go.json http://purl.obolibrary.org/obo/GO_0102423 GO:0102422 biolink:MolecularActivity curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotetraside + UDP + H+. MetaCyc:RXN-13814 go.json http://purl.obolibrary.org/obo/GO_0102422 GO:0102425 biolink:MolecularActivity myricetin 3-O-glucosyltransferase activity Catalysis of the reaction: myricetin + UDP-alpha-D-glucose = myricetin 3-O-beta-D-glucopyranoside + UDP. EC:2.4.1.91|MetaCyc:RXN-13822 go.json http://purl.obolibrary.org/obo/GO_0102425 GO:0102424 biolink:MolecularActivity sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+. MetaCyc:RXN-13821 go.json http://purl.obolibrary.org/obo/GO_0102424 GO:0102427 biolink:MolecularActivity allocryptopine 6-hydroxylase activity Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ = 6-hydroxy-allocryptopine + NADP + H2O. MetaCyc:RXN-13828 go.json http://purl.obolibrary.org/obo/GO_0102427 GO:0102426 biolink:MolecularActivity myricetin-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose = myricetin 3-O-gentiobioside + UDP + H+. MetaCyc:RXN-13823 go.json http://purl.obolibrary.org/obo/GO_0102426 GO:0102429 biolink:MolecularActivity genistein-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: genistin + UDP-alpha-D-glucose = genistin 7-gentiobioside + UDP + H+. MetaCyc:RXN-13831 go.json http://purl.obolibrary.org/obo/GO_0102429 GO:0102428 biolink:MolecularActivity kaempferol-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose = kaempferol-3-gentiobioside + UDP. MetaCyc:RXN-13830 go.json http://purl.obolibrary.org/obo/GO_0102428 GO:0018597 biolink:MolecularActivity ammonia monooxygenase activity Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions. EC:1.14.99.39|RHEA:27341|UM-BBD_enzymeID:e0061 go.json http://purl.obolibrary.org/obo/GO_0018597 GO:0018596 biolink:MolecularActivity dimethylsilanediol hydroxylase activity Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol. UM-BBD_reactionID:r0637 go.json DMSD hydroxylase activity http://purl.obolibrary.org/obo/GO_0018596 GO:0018599 biolink:MolecularActivity 2-hydroxyisobutyrate 3-monooxygenase activity Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate. UM-BBD_reactionID:r0619 go.json http://purl.obolibrary.org/obo/GO_0018599 GO:0018598 biolink:MolecularActivity hydroxymethylsilanetriol oxidase activity Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol. UM-BBD_reactionID:r0641 go.json http://purl.obolibrary.org/obo/GO_0018598 GO:0018593 biolink:MolecularActivity 4-chlorophenoxyacetate monooxygenase activity Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol. UM-BBD_reactionID:r0281 go.json http://purl.obolibrary.org/obo/GO_0018593 GO:0018592 biolink:MolecularActivity 4-nitrocatechol 4-monooxygenase activity Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol. EC:1.14.13.166|UM-BBD_reactionID:r0231 go.json http://purl.obolibrary.org/obo/GO_0018592 GO:0018595 biolink:MolecularActivity alpha-pinene monooxygenase activity Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol. EC:1.14.13.155|RHEA:32891|UM-BBD_reactionID:r0716 go.json http://purl.obolibrary.org/obo/GO_0018595 GO:0018594 biolink:MolecularActivity tert-butanol 2-monooxygenase activity Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol. go.json tert-butyl alcohol 2-monooxygenase activity http://purl.obolibrary.org/obo/GO_0018594 GO:0018568 biolink:MolecularActivity 3,4-dihydroxyphenanthrene dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate. EC:1.13.11.-|UM-BBD_reactionID:r0501 go.json http://purl.obolibrary.org/obo/GO_0018568 GO:0018567 biolink:MolecularActivity styrene dioxygenase activity Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol. EC:1.13.11.-|UM-BBD_reactionID:r0256 go.json http://purl.obolibrary.org/obo/GO_0018567 GO:0018569 biolink:MolecularActivity hydroquinone 1,2-dioxygenase activity Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde. EC:1.13.11.-|UM-BBD_reactionID:r0228 go.json http://purl.obolibrary.org/obo/GO_0018569 GO:0018564 biolink:MolecularActivity carbazole 1,9a-dioxygenase activity Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol. EC:1.13.11.-|UM-BBD_reactionID:r0456 go.json carbazole 1,9alpha-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018564 GO:0018563 biolink:MolecularActivity 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate. EC:1.13.11.-|UM-BBD_reactionID:r0310 go.json http://purl.obolibrary.org/obo/GO_0018563 GO:0018566 biolink:MolecularActivity 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate. EC:1.13.11.-|UM-BBD_reactionID:r0324 go.json 1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018566 GO:0018565 biolink:MolecularActivity dihydroxydibenzothiophene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. EC:1.13.11.-|UM-BBD_reactionID:r0162 go.json http://purl.obolibrary.org/obo/GO_0018565 GO:0018560 biolink:MolecularActivity protocatechuate 3,4-dioxygenase type II activity Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate. EC:1.13.11.-|UM-BBD_reactionID:r0581 go.json http://purl.obolibrary.org/obo/GO_0018560 GO:0018562 biolink:MolecularActivity 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid. EC:1.13.11.-|UM-BBD_reactionID:r0415 go.json http://purl.obolibrary.org/obo/GO_0018562 GO:0018561 biolink:MolecularActivity 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate. EC:1.13.11.-|UM-BBD_reactionID:r0457 go.json http://purl.obolibrary.org/obo/GO_0018561 GO:0018580 biolink:MolecularActivity nitronate monooxygenase activity Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite. EC:1.13.12.16|MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN|RHEA:28767 go.json 2-nitropropane dioxygenase activity|nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity http://purl.obolibrary.org/obo/GO_0018580 GO:0018579 biolink:MolecularActivity protocatechuate 4,5-dioxygenase activity Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde. EC:1.13.11.8|MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN|RHEA:24044|UM-BBD_reactionID:r0144 go.json protocatechuate 4,5-oxygenase activity|protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)|protocatechuic 4,5-dioxygenase activity|protocatechuic 4,5-oxygenase activity http://purl.obolibrary.org/obo/GO_0018579 GO:0018578 biolink:MolecularActivity protocatechuate 3,4-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. EC:1.13.11.3|MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN|RHEA:10084|UM-BBD_reactionID:r0143 go.json protocatechuate oxygenase activity|protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)|protocatechuic 3,4-dioxygenase activity|protocatechuic 3,4-oxygenase activity|protocatechuic acid oxidase activity http://purl.obolibrary.org/obo/GO_0018578 GO:0018575 biolink:MolecularActivity chlorocatechol 1,2-dioxygenase activity Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate. EC:1.13.11.-|UM-BBD_reactionID:r0655 go.json http://purl.obolibrary.org/obo/GO_0018575 GO:0018574 biolink:MolecularActivity 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate. EC:1.13.11.-|UM-BBD_enzymeID:e0422 go.json http://purl.obolibrary.org/obo/GO_0018574 GO:0018577 biolink:MolecularActivity catechol 2,3-dioxygenase activity Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde. EC:1.13.11.2|MetaCyc:CATECHOL-23-DIOXYGENASE-RXN|RHEA:17337|UM-BBD_enzymeID:e0156 go.json 2,3-pyrocatechase activity|catechol 2,3-oxygenase|catechol oxygenase|catechol:oxygen 2,3-oxidoreductase (decyclizing)|cato2ase activity|metapyrocatechase activity|pyrocatechol 2,3-dioxygenase http://purl.obolibrary.org/obo/GO_0018577 GO:0018576 biolink:MolecularActivity catechol 1,2-dioxygenase activity Catalysis of the reaction: catechol + O2 = cis,cis-muconate. EC:1.13.11.1|MetaCyc:CATECHOL-12-DIOXYGENASE-RXN|RHEA:23852|UM-BBD_enzymeID:e0064 go.json 1,2-pyrocatechase activity|CD I|CD II|catechase activity|catechol 1,2-oxygenase activity|catechol-oxygen 1,2-oxidoreductase activity|catechol:oxygen 1,2-oxidoreductase activity|pyrocatechase activity|pyrocatechol 1,2-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018576 GO:0018571 biolink:MolecularActivity 2,3-dihydroxy-p-cumate dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate. MetaCyc:RXN-666|RHEA:42568|UM-BBD_reactionID:r0397 go.json 2,3-dihydroxy-p-cumate 3,4-dioxygenase|2,3-dihydroxy-p-cumate-3,4-dioxygenase http://purl.obolibrary.org/obo/GO_0018571 GO:0018570 biolink:MolecularActivity p-cumate 2,3-dioxygenase activity Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate. EC:1.14.12.25|MetaCyc:RXN-664|RHEA:42344|UM-BBD_reactionID:r0395 go.json http://purl.obolibrary.org/obo/GO_0018570 GO:0018573 biolink:MolecularActivity 2-aminophenol 1,6-dioxygenase activity Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde. EC:1.13.11.-|UM-BBD_reactionID:r0305 go.json http://purl.obolibrary.org/obo/GO_0018573 GO:0018572 biolink:MolecularActivity 3,5-dichlorocatechol 1,2-dioxygenase activity Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate. EC:1.13.11.-|UM-BBD_reactionID:r0276 go.json http://purl.obolibrary.org/obo/GO_0018572 GO:0018549 biolink:MolecularActivity methanethiol oxidase activity Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide. EC:1.8.3.4|MetaCyc:METHANETHIOL-OXIDASE-RXN|RHEA:11812|UM-BBD_reactionID:r0209 go.json (MM)-oxidase activity|MT-oxidase activity|methanethiol:oxygen oxidoreductase activity|methyl mercaptan oxidase activity|methylmercaptan oxidase activity http://purl.obolibrary.org/obo/GO_0018549 GO:0018546 biolink:MolecularActivity nitrobenzene nitroreductase activity Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O. EC:1.7.1.16|MetaCyc:RXN-8815|RHEA:52884|UM-BBD_enzymeID:e0245 go.json http://purl.obolibrary.org/obo/GO_0018546 GO:0018545 biolink:MolecularActivity NAD(P)H nitroreductase activity Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative. UM-BBD_enzymeID:e0346 go.json http://purl.obolibrary.org/obo/GO_0018545 GO:0018548 biolink:MolecularActivity pentaerythritol trinitrate reductase activity Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate. EC:1.6.99.1|UM-BBD_reactionID:r0025 go.json xenobiotic reductase activity http://purl.obolibrary.org/obo/GO_0018548 GO:0018547 biolink:MolecularActivity nitroglycerin reductase activity Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative. Reactome:R-HSA-9620103|UM-BBD_enzymeID:e0038 go.json NG reductase activity http://purl.obolibrary.org/obo/GO_0018547 GO:0018542 biolink:MolecularActivity 2,3-dihydroxy DDT 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate. EC:1.13.11.-|UM-BBD_reactionID:r0452 go.json http://purl.obolibrary.org/obo/GO_0018542 GO:0018541 biolink:MolecularActivity p-benzoquinone reductase (NADPH) activity Catalysis of the reaction: 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+. EC:1.6.5.6|KEGG_REACTION:R05244|MetaCyc:1.6.5.6-RXN|RHEA:23488|UM-BBD_enzymeID:e0422 go.json NADPH:p-benzoquinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018541 GO:0018544 biolink:MolecularActivity 4-carboxy-4'-sulfoazobenzene reductase activity Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate. UM-BBD_reactionID:r0543 go.json 4-carboxy-4'-sulphoazobenzene reductase activity http://purl.obolibrary.org/obo/GO_0018544 GO:0018543 biolink:MolecularActivity 4-amino-2-nitroso-6-nitrotoluene reductase activity Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene. UM-BBD_reactionID:r0464 go.json http://purl.obolibrary.org/obo/GO_0018543 GO:0018540 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018540 GO:0018557 biolink:MolecularActivity 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid. EC:1.13.11.-|UM-BBD_reactionID:r0422 go.json http://purl.obolibrary.org/obo/GO_0018557 GO:0018556 biolink:MolecularActivity 2,2',3-trihydroxybiphenyl dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate). EC:1.13.11.-|UM-BBD_enzymeID:e0032 go.json http://purl.obolibrary.org/obo/GO_0018556 GO:0018559 biolink:MolecularActivity 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate. EC:1.13.11.-|UM-BBD_reactionID:r0442 go.json 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018559 GO:0018558 biolink:MolecularActivity 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon. EC:1.13.11.-|UM-BBD_reactionID:r0049 go.json http://purl.obolibrary.org/obo/GO_0018558 GO:0018553 biolink:MolecularActivity 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate. UM-BBD_enzymeID:e0309 go.json http://purl.obolibrary.org/obo/GO_0018553 GO:0018552 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018552 GO:0018555 biolink:MolecularActivity phenanthrene dioxygenase activity Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene. EC:1.13.11.-|UM-BBD_reactionID:r0455 go.json http://purl.obolibrary.org/obo/GO_0018555 GO:0018554 biolink:MolecularActivity 1,2-dihydroxynaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached. EC:1.13.11.56|RHEA:27310|UM-BBD_enzymeID:e0255 go.json http://purl.obolibrary.org/obo/GO_0018554 GO:0018551 biolink:MolecularActivity dissimilatory sulfite reductase activity Catalysis of the reactions: [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H+ + sulfite and [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H+ + sulfite. EC:1.8.99.5|MetaCyc:RXN-17803|UM-BBD_reactionID:r0627 go.json hydrogensulfite reductase activity|hydrogensulphite reductase activity http://purl.obolibrary.org/obo/GO_0018551 GO:0018550 biolink:MolecularActivity tetrachloro-p-hydroquinone reductive dehalogenase activity Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl. UM-BBD_reactionID:r0314 go.json tetrachlorohydroquinone reductive dehalogenase activity http://purl.obolibrary.org/obo/GO_0018550 GO:0102470 biolink:MolecularActivity 6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 6C-glucosyl-2-hydroxynaringenin + UDP + H+. MetaCyc:RXN-11685 go.json http://purl.obolibrary.org/obo/GO_0102470 GO:0102472 biolink:MolecularActivity eriodictyol 2-hydroxylase activity Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ = 2-hydroxyeriodictyol + NADP + H2O. MetaCyc:RXN-14077|RHEA:57596 go.json http://purl.obolibrary.org/obo/GO_0102472 GO:0102471 biolink:MolecularActivity 2-hydroxynaringenin-6C-glucoside dehydratase activity Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin = isovitexin-7-olate + H2O. MetaCyc:RXN-14076 go.json http://purl.obolibrary.org/obo/GO_0102471 GO:0102474 biolink:MolecularActivity eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+. MetaCyc:RXN-14079 go.json http://purl.obolibrary.org/obo/GO_0102474 GO:0102473 biolink:MolecularActivity eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+. MetaCyc:RXN-14079 go.json http://purl.obolibrary.org/obo/GO_0102473 GO:0102476 biolink:MolecularActivity pinocembrin 2-hydroxylase activity Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ = 2,5,7-trihydroxyflavanone + NADP + H2O. MetaCyc:RXN-14083|RHEA:57592 go.json http://purl.obolibrary.org/obo/GO_0102476 GO:0102475 biolink:MolecularActivity 2-hydroxyeriodictyol 6C-glucoside dehydratase activity Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol = isoorientin + H2O. MetaCyc:RXN-14081 go.json http://purl.obolibrary.org/obo/GO_0102475 GO:0102478 biolink:MolecularActivity beta-L-arabinofuranosidase activity Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose. EC:3.2.1.185|MetaCyc:RXN-14089|RHEA:36051 go.json http://purl.obolibrary.org/obo/GO_0102478 GO:0102477 biolink:MolecularActivity 2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone = H+ + 6C-hexosyl chrysin + H2O. MetaCyc:RXN-14088 go.json http://purl.obolibrary.org/obo/GO_0102477 GO:0102479 biolink:MolecularActivity quercetin 3-O-beta:-D-galactosyltransferase activity Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose = quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+. EC:2.4.1.234|MetaCyc:RXN-14109 go.json http://purl.obolibrary.org/obo/GO_0102479 GO:0102481 biolink:MolecularActivity 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H+. EC:3.7.1.22|MetaCyc:RXN-14149|RHEA:25836 go.json http://purl.obolibrary.org/obo/GO_0102481 GO:0102480 biolink:MolecularActivity 5-fluorocytosine deaminase activity Catalysis of the reaction: H+ + flucytosine + H2O = 5-fluorouracil + ammonium. EC:3.5.4.1|MetaCyc:RXN-14129 go.json http://purl.obolibrary.org/obo/GO_0102480 GO:0102483 biolink:MolecularActivity scopolin beta-glucosidase activity Catalysis of the reaction: H2O + scopolin = beta-D-glucose + scopoletin. EC:3.2.1.21|MetaCyc:RXN-14179 go.json http://purl.obolibrary.org/obo/GO_0102483 GO:0102482 biolink:MolecularActivity 5-deoxy-D-glucuronate isomerase activity Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate. EC:5.3.1.30|MetaCyc:RXN-14150|RHEA:25840 go.json http://purl.obolibrary.org/obo/GO_0102482 GO:0102485 biolink:MolecularActivity obsolete dATP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14195|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102485 GO:0102484 biolink:MolecularActivity esculetin glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) = esculin + UDP(3-) + H+. MetaCyc:RXN-14182 go.json http://purl.obolibrary.org/obo/GO_0102484 GO:0102487 biolink:MolecularActivity obsolete dUTP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14199|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102487 GO:0102486 biolink:MolecularActivity obsolete dCTP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14198|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102486 GO:0102489 biolink:MolecularActivity obsolete GTP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14201|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102489 GO:0043500 biolink:BiologicalProcess muscle adaptation A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. go.json muscle plasticity http://purl.obolibrary.org/obo/GO_0043500 goslim_pir GO:0102488 biolink:MolecularActivity obsolete dTTP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14200|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102488 GO:0043506 biolink:BiologicalProcess regulation of JUN kinase activity Any process that modulates the frequency, rate or extent of JUN kinase activity. go.json regulation of JUNK activity http://purl.obolibrary.org/obo/GO_0043506 gocheck_do_not_annotate GO:0043505 biolink:CellularComponent CENP-A containing nucleosome A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). go.json CENP-S-T-W-X|CNP-T-W-S-X complex|CenH3 containing nucleosome|centromere specific nucleosome|centromere-specific nucleosome|centromeric nucleosome http://purl.obolibrary.org/obo/GO_0043505 GO:0043508 biolink:BiologicalProcess negative regulation of JUN kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. go.json down regulation of JNK activity|down-regulation of JNK activity|downregulation of JNK activity|inhibition of JNK activity|negative regulation of JUNK activity http://purl.obolibrary.org/obo/GO_0043508 gocheck_do_not_annotate GO:0043507 biolink:BiologicalProcess positive regulation of JUN kinase activity Any process that activates or increases the frequency, rate or extent of JUN kinase activity. go.json positive regulation of JUNK activity|stimulation of JNK activity|up regulation of JNK activity|up-regulation of JNK activity|upregulation of JNK activity http://purl.obolibrary.org/obo/GO_0043507 gocheck_do_not_annotate GO:0043502 biolink:BiologicalProcess regulation of muscle adaptation Any process that modulates the frequency, rate or extent of muscle adaptation. go.json regulation of muscle plasticity http://purl.obolibrary.org/obo/GO_0043502 GO:0043501 biolink:BiologicalProcess skeletal muscle adaptation Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. go.json skeletal muscle plasticity http://purl.obolibrary.org/obo/GO_0043501 GO:0043504 biolink:BiologicalProcess mitochondrial DNA repair The process of restoring mitochondrial DNA after damage. go.json http://purl.obolibrary.org/obo/GO_0043504 GO:0043503 biolink:BiologicalProcess skeletal muscle fiber adaptation Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. go.json skeletal muscle fiber plasticity|skeletal muscle fibre plasticity|skeletal myofiber plasticity|skeletal myofibre plasticity http://purl.obolibrary.org/obo/GO_0043503 GO:0043509 biolink:CellularComponent activin A complex A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A). go.json http://purl.obolibrary.org/obo/GO_0043509 GO:0102490 biolink:MolecularActivity obsolete 8-oxo-dGTP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: 8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14205|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102490 GO:0102491 biolink:MolecularActivity obsolete dGTP phosphohydrolase activity OBSOLETE. Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+. EC:3.6.1.5|MetaCyc:RXN-14208|https://github.com/geneontology/go-ontology/issues/23454 go.json True http://purl.obolibrary.org/obo/GO_0102491 GO:0102494 biolink:MolecularActivity GA20 2,3-desaturase activity Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor = gibberellin A5 + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-14317 go.json http://purl.obolibrary.org/obo/GO_0102494 GO:0102493 biolink:MolecularActivity wogonin 7-O-glucosyltransferase activity Catalysis of the reaction: wogonin + UDP-alpha-D-glucose = wogonin 7-O-beta-D-glucoside + UDP + H+. MetaCyc:RXN-14239 go.json http://purl.obolibrary.org/obo/GO_0102493 GO:0102496 biolink:MolecularActivity GA5 2,3 epoxidase activity Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A6 + succinate + carbon dioxide. MetaCyc:RXN-14327 go.json http://purl.obolibrary.org/obo/GO_0102496 GO:0102495 biolink:MolecularActivity GA5 3beta-hydroxylase activity Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A3 + succinate + carbon dioxide. MetaCyc:RXN-14318 go.json http://purl.obolibrary.org/obo/GO_0102495 GO:0102498 biolink:MolecularActivity maltose glucosidase activity Catalysis of the reaction: H2O + maltose = 2 glucose. MetaCyc:RXN-15910 go.json http://purl.obolibrary.org/obo/GO_0102498 GO:0102497 biolink:MolecularActivity scyllo-inositol dehydrogenase (NADP+) activity Catalysis of the reaction: scyllo-inositol + NADP = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+. EC:1.1.1.371|MetaCyc:RXN-14347|RHEA:39063 go.json http://purl.obolibrary.org/obo/GO_0102497 GO:0043511 biolink:CellularComponent inhibin complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B. go.json http://purl.obolibrary.org/obo/GO_0043511 goslim_pir GO:0043510 biolink:CellularComponent activin B complex A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B). go.json http://purl.obolibrary.org/obo/GO_0043510 GO:0102499 biolink:MolecularActivity SHG alpha-glucan phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan. EC:2.4.1.1|MetaCyc:RXN-14353|RHEA:41732 go.json http://purl.obolibrary.org/obo/GO_0102499 GO:0043517 biolink:BiologicalProcess positive regulation of DNA damage response, signal transduction by p53 class mediator Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. go.json activation of DNA damage response, signal transduction by p53 class mediator|positive regulation of p53 induced by DNA damage response|stimulation of DNA damage response, signal transduction by p53 class mediator|up regulation of DNA damage response, signal transduction by p53 class mediator|up-regulation of DNA damage response, signal transduction by p53 class mediator|upregulation of DNA damage response, signal transduction by p53 class mediator http://purl.obolibrary.org/obo/GO_0043517 GO:0043516 biolink:BiologicalProcess regulation of DNA damage response, signal transduction by p53 class mediator Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. go.json regulation of p53 induced by DNA damage response http://purl.obolibrary.org/obo/GO_0043516 GO:0043519 biolink:BiologicalProcess regulation of myosin II filament organization Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules. go.json regulation of myosin II filament assembly or disassembly|regulation of myosin II filament organisation http://purl.obolibrary.org/obo/GO_0043519 GO:0043518 biolink:BiologicalProcess negative regulation of DNA damage response, signal transduction by p53 class mediator Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. go.json down regulation of DNA damage response, signal transduction by p53 class mediator|down-regulation of DNA damage response, signal transduction by p53 class mediator|downregulation of DNA damage response, signal transduction by p53 class mediator|inhibition of DNA damage response, signal transduction by p53 class mediator|negative regulation of p53 induced by DNA damage response http://purl.obolibrary.org/obo/GO_0043518 GO:0043513 biolink:CellularComponent inhibin B complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit. go.json http://purl.obolibrary.org/obo/GO_0043513 GO:0043512 biolink:CellularComponent inhibin A complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit. go.json http://purl.obolibrary.org/obo/GO_0043512 GO:0043515 biolink:MolecularActivity kinetochore binding Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. go.json http://purl.obolibrary.org/obo/GO_0043515 GO:0043514 biolink:CellularComponent interleukin-12 complex A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space. go.json IL-12 complex|IL12A|IL12B|p35|p40 http://purl.obolibrary.org/obo/GO_0043514 GO:0043520 biolink:BiologicalProcess regulation of myosin II filament assembly Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules. go.json http://purl.obolibrary.org/obo/GO_0043520 GO:0043522 biolink:MolecularActivity leucine zipper domain binding Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. go.json leucine zipper binding http://purl.obolibrary.org/obo/GO_0043522 GO:0043521 biolink:BiologicalProcess regulation of myosin II filament disassembly Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules. go.json http://purl.obolibrary.org/obo/GO_0043521 GO:0043528 biolink:CellularComponent tRNA (m2G10) methyltransferase complex A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p. go.json http://purl.obolibrary.org/obo/GO_0043528 GO:0043527 biolink:CellularComponent tRNA methyltransferase complex A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. go.json http://purl.obolibrary.org/obo/GO_0043527 goslim_pir GO:0043529 biolink:CellularComponent GET complex An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins. go.json http://purl.obolibrary.org/obo/GO_0043529 GO:0043524 biolink:BiologicalProcess negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. go.json down regulation of neuron apoptosis|down-regulation of neuron apoptosis|downregulation of neuron apoptosis|inhibition of neuron apoptosis|negative regulation of neuron apoptosis|negative regulation of programmed cell death, neurons|neuron survival http://purl.obolibrary.org/obo/GO_0043524 GO:0043523 biolink:BiologicalProcess regulation of neuron apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. go.json regulation of apoptosis of neuronal cells|regulation of apoptosis of neurons|regulation of neuron apoptosis|regulation of neuron programmed cell death|regulation of neuronal cell programmed cell death|regulation of programmed cell death of neuronal cells|regulation of programmed cell death, neurons http://purl.obolibrary.org/obo/GO_0043523 GO:0043526 biolink:BiologicalProcess obsolete neuroprotection OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss. Wikipedia:Neuroprotection go.json neuroprotection True http://purl.obolibrary.org/obo/GO_0043526 GO:0043525 biolink:BiologicalProcess positive regulation of neuron apoptotic process Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. go.json activation of neuron apoptosis|positive regulation of neuron apoptosis|positive regulation of programmed cell death, neurons|stimulation of neuron apoptosis|up regulation of neuron apoptosis|up-regulation of neuron apoptosis|upregulation of neuron apoptosis http://purl.obolibrary.org/obo/GO_0043525 GO:0102430 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102430 GO:0043531 biolink:MolecularActivity ADP binding Binding to ADP, adenosine 5'-diphosphate. go.json adenosine 5'-diphosphate binding|adenosine diphosphate binding http://purl.obolibrary.org/obo/GO_0043531 GO:0102432 biolink:MolecularActivity quercetin 7-O-methyltransferase activity Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = rhamnetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13906 go.json http://purl.obolibrary.org/obo/GO_0102432 GO:0102431 biolink:MolecularActivity acyl-lipid omega-(9-4) desaturase activity Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid) and add a fourth double bond (a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid). EC:1.14.19.12|MetaCyc:RXN-13857|MetaCyc:RXN-13858 go.json acyl-lipid omega-(9-4) desaturase|alpha-linolenate delta5 desaturase activity|linoleate delta5 desaturase activity http://purl.obolibrary.org/obo/GO_0102431 GO:0043530 biolink:MolecularActivity adenosine 5'-monophosphoramidase activity Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. RHEA:67916 go.json adenosine 5' monophosphoramidase activity|adenosine 5'-monophosphoramidate hydrolase activity http://purl.obolibrary.org/obo/GO_0043530 GO:0102434 biolink:MolecularActivity pterin-4alpha-carbinolamine dehydratase activity Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate. MetaCyc:RXN-13908 go.json http://purl.obolibrary.org/obo/GO_0102434 GO:0043533 biolink:MolecularActivity inositol 1,3,4,5 tetrakisphosphate binding Binding to inositol 1,3,4,5 tetrakisphosphate. go.json IP4 binding|InsP4 binding http://purl.obolibrary.org/obo/GO_0043533 GO:0102433 biolink:MolecularActivity phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate = L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine. MetaCyc:RXN-13907 go.json http://purl.obolibrary.org/obo/GO_0102433 GO:0043532 biolink:MolecularActivity angiostatin binding Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0043532 GO:0102436 biolink:MolecularActivity 7-methylmyricetin 4'-O-methyltransferase activity Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine = 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13911 go.json http://purl.obolibrary.org/obo/GO_0102436 GO:0102435 biolink:MolecularActivity myricetin 7-O-methyltransferase activity Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine = 7-O-methylmyricetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13910 go.json http://purl.obolibrary.org/obo/GO_0102435 GO:0102438 biolink:MolecularActivity laricitrin 4'-O-methyltransferase activity Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine = H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13914 go.json http://purl.obolibrary.org/obo/GO_0102438 GO:0102437 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102437 GO:0043539 biolink:MolecularActivity protein serine/threonine kinase activator activity Binds to and increases the activity of a protein serine/threonine kinase. go.json protein ser/thr kinase activator activity http://purl.obolibrary.org/obo/GO_0043539 GO:0102439 biolink:MolecularActivity 3',4',5'-trimethylmyricetin 7-O-methyltransferase activity Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13916 go.json http://purl.obolibrary.org/obo/GO_0102439 GO:0043538 biolink:BiologicalProcess regulation of actin phosphorylation Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule. go.json http://purl.obolibrary.org/obo/GO_0043538 GO:0043535 biolink:BiologicalProcess regulation of blood vessel endothelial cell migration Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. go.json http://purl.obolibrary.org/obo/GO_0043535 GO:0043534 biolink:BiologicalProcess blood vessel endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0043534 GO:0043537 biolink:BiologicalProcess negative regulation of blood vessel endothelial cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. go.json down regulation of blood vessel endothelial cell migration|down-regulation of blood vessel endothelial cell migration|downregulation of blood vessel endothelial cell migration|inhibition of blood vessel endothelial cell migration http://purl.obolibrary.org/obo/GO_0043537 GO:0043536 biolink:BiologicalProcess positive regulation of blood vessel endothelial cell migration Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. go.json activation of blood vessel endothelial cell migration|stimulation of blood vessel endothelial cell migration|up regulation of blood vessel endothelial cell migration|up-regulation of blood vessel endothelial cell migration|upregulation of blood vessel endothelial cell migration http://purl.obolibrary.org/obo/GO_0043536 GO:0102441 biolink:MolecularActivity syringetin 7-O-methyltransferase activity Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine = 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13919 go.json http://purl.obolibrary.org/obo/GO_0102441 GO:0102440 biolink:MolecularActivity 3',4',5'-trimethylmyricetin 3-O-methyltransferase activity Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13918 go.json http://purl.obolibrary.org/obo/GO_0102440 GO:0102443 biolink:MolecularActivity L-2-hydroxycarboxylate dehydrogenase (NAD+) activity Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate = NADH(2-) + H+ + a 2-oxo carboxylate. EC:1.1.1.337|MetaCyc:RXN-13927|RHEA:34555 go.json http://purl.obolibrary.org/obo/GO_0102443 GO:0043542 biolink:BiologicalProcess endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. go.json http://purl.obolibrary.org/obo/GO_0043542 GO:0102442 biolink:MolecularActivity syringetin 3-O-methyltransferase activity Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine = 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13920 go.json http://purl.obolibrary.org/obo/GO_0102442 GO:0043541 biolink:CellularComponent UDP-N-acetylglucosamine transferase complex A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis. go.json http://purl.obolibrary.org/obo/GO_0043541 GO:0102445 biolink:MolecularActivity 3-methylquercetin 3'-O-methyltransferase activity Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine = 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13930 go.json http://purl.obolibrary.org/obo/GO_0102445 GO:0043544 biolink:MolecularActivity lipoamide binding Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. go.json http://purl.obolibrary.org/obo/GO_0043544 GO:0043543 biolink:BiologicalProcess protein acylation The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. go.json protein amino acid acylation http://purl.obolibrary.org/obo/GO_0043543 gocheck_do_not_annotate|goslim_yeast GO:0102444 biolink:MolecularActivity isorhamnetin 3-O-methyltransferase activity Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine = 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine. MetaCyc:RXN-13929 go.json http://purl.obolibrary.org/obo/GO_0102444 GO:0102447 biolink:MolecularActivity rhamnetin 3'-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13933 go.json http://purl.obolibrary.org/obo/GO_0102447 GO:0102446 biolink:MolecularActivity rhamnetin 3-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13932 go.json http://purl.obolibrary.org/obo/GO_0102446 GO:0043540 biolink:CellularComponent 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis. go.json 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex http://purl.obolibrary.org/obo/GO_0043540 GO:0102449 biolink:MolecularActivity kaempferol 3-O-methyltransferase activity Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine = 3-O-methylkaempferol + S-adenosyl-L-homocysteine. MetaCyc:RXN-13935 go.json http://purl.obolibrary.org/obo/GO_0102449 GO:0102448 biolink:MolecularActivity rhamnetin 4'-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = ombuin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13934 go.json http://purl.obolibrary.org/obo/GO_0102448 GO:0043549 biolink:BiologicalProcess regulation of kinase activity Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0043549 gocheck_do_not_annotate GO:0043546 biolink:MolecularActivity molybdopterin cofactor binding Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. go.json Moco binding http://purl.obolibrary.org/obo/GO_0043546 GO:0043545 biolink:BiologicalProcess molybdopterin cofactor metabolic process The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. go.json Moco metabolic process|Moco metabolism|molybdopterin cofactor metabolism http://purl.obolibrary.org/obo/GO_0043545 GO:0043548 biolink:MolecularActivity phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. go.json PI3K binding|phosphoinositide 3-kinase binding http://purl.obolibrary.org/obo/GO_0043548 GO:0043547 biolink:BiologicalProcess positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. go.json activation of GTPase activity|positive regulation of ARF GTPase activity|positive regulation of Cdc42 GTPase activity|positive regulation of Rab GTPase activity|positive regulation of Rac GTPase activity|positive regulation of Ral GTPase activity|positive regulation of Ran GTPase activity|positive regulation of Rap GTPase activity|positive regulation of Ras GTPase activity|positive regulation of Rho GTPase activity|stimulation of ARF GTPase activity|stimulation of Cdc42 GTPase activity|stimulation of GTPase activity|stimulation of Rab GTPase activity|stimulation of Rac GTPase activity|stimulation of Ral GTPase activity|stimulation of Ran GTPase activity|stimulation of Rap GTPase activity|stimulation of Ras GTPase activity|stimulation of Rho GTPase activity|up regulation of ARF GTPase activity|up regulation of Cdc42 GTPase activity|up regulation of GTPase activity|up regulation of Rab GTPase activity|up regulation of Rac GTPase activity|up regulation of Ral GTPase activity|up regulation of Ran GTPase activity|up regulation of Rap GTPase activity|up regulation of Ras GTPase activity|up regulation of Rho GTPase activity|up-regulation of ARF GTPase activity|up-regulation of Cdc42 GTPase activity|up-regulation of GTPase activity|up-regulation of Rab GTPase activity|up-regulation of Rac GTPase activity|up-regulation of Ral GTPase activity|up-regulation of Ran GTPase activity|up-regulation of Rap GTPase activity|up-regulation of Ras GTPase activity|up-regulation of Rho GTPase activity|upregulation of ARF GTPase activity|upregulation of Cdc42 GTPase activity|upregulation of GTPase activity|upregulation of Rab GTPase activity|upregulation of Rac GTPase activity|upregulation of Ral GTPase activity|upregulation of Ran GTPase activity|upregulation of Rap GTPase activity|upregulation of Ras GTPase activity|upregulation of Rho GTPase activity http://purl.obolibrary.org/obo/GO_0043547 gocheck_do_not_annotate GO:0102450 biolink:MolecularActivity kaempferide 7-O-methyltransferase activity Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine = 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine. MetaCyc:RXN-13936 go.json http://purl.obolibrary.org/obo/GO_0102450 GO:0102452 biolink:MolecularActivity bisdemethoxycurcumin synthase activity Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ = 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide. EC:2.3.1.211|MetaCyc:RXN-13958|RHEA:34803 go.json http://purl.obolibrary.org/obo/GO_0102452 GO:0102451 biolink:MolecularActivity kaempferide 3-O-methyltransferase activity Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine = 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine. MetaCyc:RXN-13937 go.json http://purl.obolibrary.org/obo/GO_0102451 GO:0043553 biolink:BiologicalProcess obsolete negative regulation of phosphatidylinositol 3-kinase activity OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity. go.json down regulation of phosphatidylinositol 3-kinase activity|down-regulation of phosphatidylinositol 3-kinase activity|downregulation of phosphatidylinositol 3-kinase activity|inhibition of phosphatidylinositol 3-kinase activity|negative regulation of PI3K activity|negative regulation of phosphoinositide 3-kinase activity True http://purl.obolibrary.org/obo/GO_0043553 GO:0102454 biolink:MolecularActivity cyanidin 3-O-galactosyltransferase activity Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP. EC:2.4.1.294|MetaCyc:RXN-13960|RHEA:35631 go.json http://purl.obolibrary.org/obo/GO_0102454 GO:0043552 biolink:BiologicalProcess obsolete positive regulation of phosphatidylinositol 3-kinase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity. go.json activation of phosphatidylinositol 3-kinase activity|positive regulation of phosphoinositide 3-kinase activity|stimulation of phosphatidylinositol 3-kinase activity|up regulation of phosphatidylinositol 3-kinase activity|up-regulation of phosphatidylinositol 3-kinase activity|upregulation of phosphatidylinositol 3-kinase activity True http://purl.obolibrary.org/obo/GO_0043552 GO:0102453 biolink:MolecularActivity anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]. EC:2.3.1.215|MetaCyc:RXN-13959|RHEA:35411 go.json http://purl.obolibrary.org/obo/GO_0102453 GO:0043555 biolink:BiologicalProcess regulation of translation in response to stress Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json translational stress response http://purl.obolibrary.org/obo/GO_0043555 GO:0102456 biolink:MolecularActivity cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose = cyanin betaine + trans-sinapate + H+. MetaCyc:RXN-13967 go.json http://purl.obolibrary.org/obo/GO_0102456 GO:0102455 biolink:MolecularActivity anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside. EC:2.4.1.297|MetaCyc:RXN-13965|RHEA:35419 go.json http://purl.obolibrary.org/obo/GO_0102455 GO:0043554 biolink:BiologicalProcess aerobic respiration, using arsenite as electron donor The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems. go.json http://purl.obolibrary.org/obo/GO_0043554 GO:0102458 biolink:MolecularActivity cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose = cyanin betaine + vanillate + H+. EC:2.4.1.299|MetaCyc:RXN-13970 go.json http://purl.obolibrary.org/obo/GO_0102458 GO:0102457 biolink:MolecularActivity cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose = H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate. EC:2.4.1.300|MetaCyc:RXN-13969|RHEA:35431 go.json http://purl.obolibrary.org/obo/GO_0102457 GO:0043551 biolink:BiologicalProcess obsolete regulation of phosphatidylinositol 3-kinase activity OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. go.json regulation of phosphoinositide 3-kinase activity True http://purl.obolibrary.org/obo/GO_0043551 GO:0102459 biolink:MolecularActivity 8-oxo-dADP diphosphate phosphatase activity Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+. MetaCyc:RXN-14005 go.json 8-oxo-deoxyadenine diphosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0102459 GO:0043550 biolink:BiologicalProcess regulation of lipid kinase activity Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. go.json http://purl.obolibrary.org/obo/GO_0043550 gocheck_do_not_annotate GO:0043557 biolink:BiologicalProcess regulation of translation in response to osmotic stress Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json http://purl.obolibrary.org/obo/GO_0043557 GO:0043556 biolink:BiologicalProcess regulation of translation in response to oxidative stress Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0043556 GO:0043559 biolink:MolecularActivity insulin binding Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. go.json http://purl.obolibrary.org/obo/GO_0043559 GO:0043558 biolink:BiologicalProcess regulation of translational initiation in response to stress Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. go.json regulation of translation initiation in response to stress http://purl.obolibrary.org/obo/GO_0043558 GO:0102461 biolink:MolecularActivity kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP. MetaCyc:RXN-14009 go.json http://purl.obolibrary.org/obo/GO_0102461 GO:0102460 biolink:MolecularActivity kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP. MetaCyc:RXN-14008 go.json http://purl.obolibrary.org/obo/GO_0102460 GO:0102463 biolink:MolecularActivity quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose = quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+. MetaCyc:RXN-14012 go.json http://purl.obolibrary.org/obo/GO_0102463 GO:0102462 biolink:MolecularActivity quercetin 3-sophoroside 7-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+. MetaCyc:RXN-14011 go.json http://purl.obolibrary.org/obo/GO_0102462 GO:0102465 biolink:MolecularActivity zeaxanthin 2,2'-beta-hydroxylase activity Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 = nostoxanthin + 2 NAD + 2 H2O. MetaCyc:RXN-14018 go.json http://purl.obolibrary.org/obo/GO_0102465 GO:0043564 biolink:CellularComponent Ku70:Ku80 complex Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. go.json Ku70:Ku80 heterodimer http://purl.obolibrary.org/obo/GO_0043564 GO:0102464 biolink:MolecularActivity zeaxanthin 2-beta-hydroxylase activity Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ = caloxanthin + H2O + NAD. MetaCyc:RXN-14016 go.json http://purl.obolibrary.org/obo/GO_0102464 GO:0043563 biolink:MolecularActivity obsolete odorant transporter activity OBSOLETE. Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells. go.json True http://purl.obolibrary.org/obo/GO_0043563 GO:0102467 biolink:MolecularActivity scutellarein 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein = UDP( + scutellarin + H+. EC:2.4.1.253|MetaCyc:RXN-14058|RHEA:28318 go.json http://purl.obolibrary.org/obo/GO_0102467 GO:0043566 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043566 GO:0043565 biolink:MolecularActivity sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. go.json sequence specific DNA binding http://purl.obolibrary.org/obo/GO_0043565 GO:0102466 biolink:MolecularActivity beta-carotene 2,2'-beta-hydroxylase activity Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O. MetaCyc:RXN-14019 go.json http://purl.obolibrary.org/obo/GO_0102466 GO:0043560 biolink:MolecularActivity insulin receptor substrate binding Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. go.json IRS [protein] binding|IRS binding|insulin receptor substrate [protein] binding http://purl.obolibrary.org/obo/GO_0043560 GO:0102469 biolink:MolecularActivity naringenin 2-hydroxylase activity Catalysis of the reaction: (S)-naringenin + NADPH + O2 = 2-hydroxynaringenin + NADP + H2O. MetaCyc:RXN-14069|RHEA:57588 go.json http://purl.obolibrary.org/obo/GO_0102469 GO:0102468 biolink:MolecularActivity wogonin 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate + H+. EC:2.4.1.253|MetaCyc:RXN-14060|RHEA:28322 go.json http://purl.obolibrary.org/obo/GO_0102468 GO:0043562 biolink:BiologicalProcess cellular response to nitrogen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. go.json http://purl.obolibrary.org/obo/GO_0043562 GO:0043561 biolink:BiologicalProcess regulation of translational initiation in response to osmotic stress Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json http://purl.obolibrary.org/obo/GO_0043561 GO:0043568 biolink:BiologicalProcess positive regulation of insulin-like growth factor receptor signaling pathway Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. go.json activation of insulin-like growth factor receptor signaling pathway|positive regulation of IGF receptor signaling pathway|positive regulation of IGF receptor signalling pathway|positive regulation of insulin-like growth factor receptor signalling pathway|stimulation of insulin-like growth factor receptor signaling pathway|up regulation of insulin-like growth factor receptor signaling pathway|up-regulation of insulin-like growth factor receptor signaling pathway|upregulation of insulin-like growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0043568 GO:0043567 biolink:BiologicalProcess regulation of insulin-like growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. go.json regulation of IGF receptor signaling pathway|regulation of IGF receptor signalling pathway|regulation of insulin-like growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0043567 GO:0043569 biolink:BiologicalProcess negative regulation of insulin-like growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling. go.json down regulation of insulin-like growth factor receptor signaling pathway|down-regulation of insulin-like growth factor receptor signaling pathway|downregulation of insulin-like growth factor receptor signaling pathway|inhibition of insulin-like growth factor receptor signaling pathway|negative regulation of IGF receptor signaling pathway|negative regulation of IGF receptor signalling pathway|negative regulation of insulin-like growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0043569 GO:0018528 biolink:MolecularActivity iminodiacetate dehydrogenase activity Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine. UM-BBD_reactionID:r0589 go.json http://purl.obolibrary.org/obo/GO_0018528 GO:0018527 biolink:MolecularActivity cyclohexylamine oxidase activity Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide. EC:1.4.3.12|MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN|RHEA:18433|UM-BBD_reactionID:r0754 go.json cyclohexylamine:oxygen oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0018527 GO:0018529 biolink:MolecularActivity nitrilotriacetate monooxygenase activity Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate. EC:1.14.14.10|UM-BBD_reactionID:r0587 go.json http://purl.obolibrary.org/obo/GO_0018529 GO:0018524 biolink:MolecularActivity acetophenone carboxylase activity Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate. EC:6.4.1.-|UM-BBD_reactionID:r0033 go.json http://purl.obolibrary.org/obo/GO_0018524 GO:0018523 biolink:MolecularActivity quinoline 2-oxidoreductase activity Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor. EC:1.3.99.17|MetaCyc:1.3.99.17-RXN|RHEA:17749|UM-BBD_reactionID:r0045 go.json quinoline:acceptor 2-oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0018523 GO:0018526 biolink:MolecularActivity 2-aminobenzoyl-CoA reductase activity Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA. UM-BBD_reactionID:r0342 go.json http://purl.obolibrary.org/obo/GO_0018526 GO:0018525 biolink:MolecularActivity 4-hydroxybenzoyl-CoA reductase activity Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin. EC:1.1.7.1|KEGG_REACTION:R05316|MetaCyc:OHBENZCOARED-RXN|RHEA:29603|UM-BBD_reactionID:r0158 go.json 4-hydroxybenzoyl-coA reductase (dehydroxylating) activity|4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018525 GO:0018520 biolink:MolecularActivity cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2. EC:1.3.1.67|MetaCyc:1.3.1.67-RXN|UM-BBD_reactionID:r0179 go.json 4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity|cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0018520 GO:0018522 biolink:MolecularActivity benzoyl-CoA reductase activity Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H2O + benzoyl-CoA + reduced ferredoxin. EC:1.3.7.8|KEGG_REACTION:R02451|MetaCyc:1.3.99.15-RXN|RHEA:30199|UM-BBD_reactionID:r0190 go.json benzoyl-CoA reductase (dearomatizing) activity|cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity http://purl.obolibrary.org/obo/GO_0018522 GO:0018521 biolink:MolecularActivity 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH. EC:1.3.1.68|KEGG_REACTION:R05314|MetaCyc:1.3.1.68-RXN|RHEA:15657|UM-BBD_reactionID:r0224 go.json 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating) http://purl.obolibrary.org/obo/GO_0018521 GO:0018538 biolink:MolecularActivity epoxide carboxylase activity Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+. go.json http://purl.obolibrary.org/obo/GO_0018538 GO:0018535 biolink:MolecularActivity nicotine dehydrogenase activity Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor. EC:1.5.99.4|MetaCyc:NICOTINE-DEHYDROGENASE-RXN|RHEA:14769|UM-BBD_enzymeID:e0337 go.json D-nicotine oxidase activity|nicotine oxidase activity|nicotine:(acceptor) 6-oxidoreductase (hydroxylating)|nicotine:acceptor 6-oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0018535 GO:0018534 biolink:MolecularActivity nitrilotriacetate dehydrogenase activity Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate. EC:1.5.99.-|UM-BBD_reactionID:r0588 go.json http://purl.obolibrary.org/obo/GO_0018534 GO:0018537 biolink:MolecularActivity coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H+ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420. EC:1.5.98.2|KEGG_REACTION:R04464|MetaCyc:METHELENE-THMPT-OXI-RXN|RHEA:21144|UM-BBD_reactionID:r0354 go.json 5,10-methylenetetrahydromethanopterin cyclohydrolase activity|5,10-methylenetetrahydromethanopterin reductase activity|5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|N(5),N(10)-methylenetetrahydromethanopterin reductase activity|N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|N5,N10-methylenetetrahydromethanopterin reductase activity|N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity|methylene-H(4)MPT reductase activity|methylene-H4MPT reductase activity|methylenetetrahydromethanopterin reductase activity http://purl.obolibrary.org/obo/GO_0018537 GO:0018536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018536 GO:0018531 biolink:MolecularActivity (S)-6-hydroxynicotine oxidase activity Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2. EC:1.5.3.5|KEGG_REACTION:R03202|MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN|RHEA:11880|UM-BBD_reactionID:r0478 go.json (S)-6-hydroxynicotine:oxygen oxidoreductase activity|6-hydroxy-L-nicotine oxidase activity|6-hydroxy-L-nicotine:oxygen oxidoreductase activity|L-6-hydroxynicotine oxidase activity http://purl.obolibrary.org/obo/GO_0018531 GO:0018530 biolink:MolecularActivity (R)-6-hydroxynicotine oxidase activity Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2. EC:1.5.3.6|KEGG_REACTION:R07170|MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN|RHEA:10012|UM-BBD_reactionID:r0477 go.json (R)-6-hydroxynicotine:oxygen oxidoreductase activity|6-hydroxy-D-nicotine oxidase activity|D-6-hydroxynicotine oxidase activity http://purl.obolibrary.org/obo/GO_0018530 GO:0018533 biolink:BiologicalProcess peptidyl-cysteine acetylation The acetylation of peptidyl-cysteine. go.json http://purl.obolibrary.org/obo/GO_0018533 gocheck_do_not_annotate GO:0018532 biolink:MolecularActivity 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin. EC:1.5.99.-|UM-BBD_reactionID:r0353 go.json F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity|F420-independent methylene-H4MPT dehydrogenase activity|coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity|coenzyme F420-independent methylene-H4MPT dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018532 GO:0018509 biolink:MolecularActivity cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+. EC:1.3.1.56|MetaCyc:1.3.1.56-RXN|RHEA:17033|UM-BBD_enzymeID:e0134 go.json 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity|biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity|cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018509 GO:0018506 biolink:MolecularActivity maleylacetate reductase activity Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+. EC:1.3.1.32|MetaCyc:MALEYLACETATE-REDUCTASE-RXN|UM-BBD_enzymeID:e0063 go.json 3-oxoadipate:NAD(P)+ oxidoreductase activity|maleolylacetate reductase activity http://purl.obolibrary.org/obo/GO_0018506 GO:0018505 biolink:MolecularActivity cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+. EC:1.3.1.29|MetaCyc:1.3.1.29-RXN|RHEA:11832|UM-BBD_enzymeID:e0122 go.json (+)-cis-naphthalene dihydrodiol dehydrogenase activity|1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity|cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity|cis-dihydrodiol naphthalene dehydrogenase activity|cis-naphthalene dihydrodiol dehydrogenase activity|naphthalene dihydrodiol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018505 GO:0018508 biolink:MolecularActivity cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+. UM-BBD_enzymeID:e0219 go.json benzoate cis-diol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018508 GO:0018507 biolink:MolecularActivity cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD+ = H+ + NADH + phenanthrene-3,4-diol. EC:1.3.1.49|KEGG_REACTION:R04151|MetaCyc:1.3.1.49-RXN|RHEA:16253|UM-BBD_reactionID:r0488 go.json (+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity|cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018507 GO:0018502 biolink:MolecularActivity 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone. MetaCyc:LINC-RXN|RHEA:15741|UM-BBD_reactionID:r0553 go.json http://purl.obolibrary.org/obo/GO_0018502 GO:0018501 biolink:MolecularActivity cis-chlorobenzene dihydrodiol dehydrogenase activity Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol. UM-BBD_enzymeID:e0411 go.json http://purl.obolibrary.org/obo/GO_0018501 GO:0018504 biolink:MolecularActivity cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+. EC:1.3.1.19|MetaCyc:1.3.1.19-RXN|RHEA:15457|UM-BBD_enzymeID:e0060 go.json cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity|cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity|cis-benzene glycol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018504 GO:0018503 biolink:MolecularActivity trans-1,2-dihydrodiolphenanthrene dehydrogenase activity Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene. UM-BBD_reactionID:r0574 go.json http://purl.obolibrary.org/obo/GO_0018503 GO:0018500 biolink:MolecularActivity trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene. UM-BBD_reactionID:r0575 go.json http://purl.obolibrary.org/obo/GO_0018500 GO:0018517 biolink:MolecularActivity phthalate 4,5-cis-dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH. EC:1.3.1.64|KEGG_REACTION:R05275|MetaCyc:1.3.1.64-RXN|RHEA:13837|UM-BBD_reactionID:r0142 go.json cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018517 GO:0018516 biolink:MolecularActivity 2,4-dichlorobenzoyl-CoA reductase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH. EC:1.21.1.2|KEGG_REACTION:R05276|MetaCyc:1.3.1.63-RXN|RHEA:23076|UM-BBD_reactionID:r0138 go.json 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating) http://purl.obolibrary.org/obo/GO_0018516 GO:0018519 biolink:MolecularActivity cis-dihydroethylcatechol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + H+ + NADH. EC:1.3.1.66|KEGG_REACTION:R05313|MetaCyc:1.3.1.66-RXN|RHEA:18101|UM-BBD_reactionID:r0309 go.json cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity|cis-ethylbenzene glycol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0018519 GO:0018518 biolink:MolecularActivity 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH. EC:1.3.1.65|KEGG_REACTION:R05312|MetaCyc:RXN-643|RHEA:24556|UM-BBD_reactionID:r0053 go.json 5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase|5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018518 GO:0018513 biolink:MolecularActivity dibenzothiophene dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + H+ + NADH. EC:1.3.1.60|KEGG_REACTION:R05310|MetaCyc:1.3.1.60-RXN|RHEA:24188|UM-BBD_reactionID:r0161 go.json cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018513 GO:0018512 biolink:MolecularActivity obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+. UM-BBD_reactionID:r0216 go.json 1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity|1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity True http://purl.obolibrary.org/obo/GO_0018512 GO:0018515 biolink:MolecularActivity pimeloyl-CoA dehydrogenase activity Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH. EC:1.3.1.62|KEGG_REACTION:R05311|MetaCyc:1.3.1.62-RXN|RHEA:19665|UM-BBD_reactionID:r0194 go.json pimeloyl-CoA:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018515 GO:0018514 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018514 GO:0018511 biolink:MolecularActivity 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH. EC:1.3.1.58|KEGG_REACTION:R05240|MetaCyc:RXN-665|RHEA:23772|UM-BBD_reactionID:r0396 go.json cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018511 GO:0018510 biolink:MolecularActivity phloroglucinol reductase activity Catalysis of the reaction: dihydrophloroglucinol + NADP+ = H+ + NADPH + phloroglucinol. EC:1.3.1.57|KEGG_REACTION:R05308|MetaCyc:R5-RXN|RHEA:10080|UM-BBD_reactionID:r0007 go.json dihydrophloroglucinol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018510 OBO:GOREL_0002003 biolink:OntologyClass results in distribution of GOREL:0002003 go.json http://purl.obolibrary.org/obo/GOREL_0002003 OBO:GOREL_0002004 biolink:OntologyClass results in fission of GOREL:0002004 go.json http://purl.obolibrary.org/obo/GOREL_0002004 GO:0043690 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043690 GO:0004088 biolink:MolecularActivity carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. EC:6.3.5.5|MetaCyc:CARBPSYN-RXN|RHEA:18633|Reactome:R-HSA-73577 go.json CPS activity|GD-CPSase activity|carbamoyl phosphate synthase (glutamine-hydrolyzing) activity|carbamoyl phosphate synthetase activity|carbamoyl-phosphate synthase (glutamine-hydrolysing) activity|carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity|carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity|carbamoylphosphate synthetase II activity|carbamyl phosphate synthetase (glutamine) activity|carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity|glutamine-dependent carbamoyl-phosphate synthase activity|glutamine-dependent carbamyl phosphate synthetase activity|hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity http://purl.obolibrary.org/obo/GO_0004088 GO:0043696 biolink:BiologicalProcess dedifferentiation The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors. Wikipedia:Cellular_differentiation#Dedifferentiation go.json http://purl.obolibrary.org/obo/GO_0043696 GO:0004087 biolink:MolecularActivity carbamoyl-phosphate synthase (ammonia) activity Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate. EC:6.3.4.16|KEGG_REACTION:R00149|MetaCyc:RXN-13202|RHEA:18029|Reactome:R-HSA-70555 go.json CPS I activity|carbamoyl phosphate synthase (ammonia) activity|carbamoyl-phosphate synthetase (ammonia) activity|carbamoyl-phosphate synthetase I activity|carbamoylphosphate synthase (ammonia)|carbamoylphosphate synthase activity|carbamoylphosphate synthetase (ammonia) activity|carbamylphosphate synthetase I|carbamylphosphate synthetase activity|carbmoylphosphate synthetase activity|carbon-dioxide--ammonia ligase activity|carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating) http://purl.obolibrary.org/obo/GO_0004087 GO:0043695 biolink:BiologicalProcess detection of pheromone The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0043695 GO:0043698 biolink:CellularComponent iridosome A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance. go.json reflecting platelet http://purl.obolibrary.org/obo/GO_0043698 GO:0004089 biolink:MolecularActivity carbonate dehydratase activity Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. EC:4.2.1.1|MetaCyc:RXN0-5224|RHEA:10748|Reactome:R-HSA-1237045|Reactome:R-HSA-1237047|Reactome:R-HSA-1237059|Reactome:R-HSA-1237081|Reactome:R-HSA-1475017|Reactome:R-HSA-1475022|Reactome:R-HSA-1475025|Reactome:R-HSA-1475026|Reactome:R-HSA-1475028|Reactome:R-HSA-1475032|Reactome:R-HSA-1475435|Reactome:R-HSA-1475436 go.json anhydrase activity|carbonate anhydrase activity|carbonate hydro-lyase (carbon-dioxide-forming)|carbonate hydro-lyase activity|carbonic acid anhydrase activity|carbonic anhydrase A|carbonic anhydrase activity|carbonic dehydratase activity|carboxyanhydrase activity http://purl.obolibrary.org/obo/GO_0004089 GO:0043697 biolink:BiologicalProcess cell dedifferentiation The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. go.json http://purl.obolibrary.org/obo/GO_0043697 GO:0004084 biolink:MolecularActivity branched-chain-amino-acid transaminase activity Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. EC:2.6.1.42|Reactome:R-HSA-508179|Reactome:R-HSA-508189|Reactome:R-HSA-70723|Reactome:R-HSA-70724 go.json L-branched chain amino acid aminotransferase activity|branched-chain amino acid aminotransferase activity|branched-chain amino acid-glutamate transaminase activity|branched-chain aminotransferase activity|branched-chain-amino-acid:2-oxoglutarate aminotransferase activity|glutamate-branched-chain amino acid transaminase activity|transaminase B activity http://purl.obolibrary.org/obo/GO_0004084 GO:0043692 biolink:BiologicalProcess monoterpene metabolic process The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure. go.json monoterpene metabolism http://purl.obolibrary.org/obo/GO_0043692 GO:0043691 biolink:BiologicalProcess reverse cholesterol transport The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. go.json http://purl.obolibrary.org/obo/GO_0043691 GO:0004083 biolink:MolecularActivity obsolete bisphosphoglycerate 2-phosphatase activity OBSOLETE. Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate. go.json True http://purl.obolibrary.org/obo/GO_0004083 GO:0004086 biolink:MolecularActivity obsolete carbamoyl-phosphate synthase activity OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate. go.json carbamoyl phosphate synthase activity|carbamoyl-phosphate synthase activity True http://purl.obolibrary.org/obo/GO_0004086 GO:0043694 biolink:BiologicalProcess monoterpene catabolic process The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure. go.json monoterpene catabolism http://purl.obolibrary.org/obo/GO_0043694 GO:0004085 biolink:MolecularActivity butyryl-CoA dehydrogenase activity Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein. EC:1.3.8.1|KEGG_REACTION:R01178|MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN|RHEA:24004|UM-BBD_reactionID:r0013 go.json 3-hydroxyacyl CoA reductase activity|butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity|butanoyl-CoA:acceptor 2,3-oxidoreductase activity|butyryl coenzyme A dehydrogenase activity|butyryl dehydrogenase activity|enoyl-coenzyme A reductase activity|ethylene reductase activity|short-chain acyl CoA dehydrogenase activity|short-chain acyl-coenzyme A dehydrogenase activity|short-chain-acyl-CoA dehydrogenase activity|unsaturated acyl coenzyme A reductase activity|unsaturated acyl-CoA reductase activity http://purl.obolibrary.org/obo/GO_0004085 GO:0043693 biolink:BiologicalProcess monoterpene biosynthetic process The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure. go.json monoterpene biosynthesis http://purl.obolibrary.org/obo/GO_0043693 GO:0004091 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004091 GO:0004090 biolink:MolecularActivity carbonyl reductase (NADPH) activity Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. EC:1.1.1.184|MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN|RHEA:19257|Reactome:R-HSA-8937419 go.json ALR3|NADPH-dependent carbonyl reductase activity|NADPH2-dependent carbonyl reductase activity|aldehyde reductase 1|aldehyde reductase I activity|carbonyl reductase activity|nonspecific NADPH-dependent carbonyl reductase activity|prostaglandin 9-ketoreductase activity|secondary-alcohol:NADP+ oxidoreductase activity|xenobiotic ketone reductase activity http://purl.obolibrary.org/obo/GO_0004090 GO:0004093 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004093 GO:0004092 biolink:MolecularActivity carnitine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA. EC:2.3.1.7|KEGG_REACTION:R02396|MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN|RHEA:21136|Reactome:R-HSA-390284|Reactome:R-HSA-390291 go.json CATC|acetyl-CoA-carnitine O-acetyltransferase activity|acetyl-CoA:carnitine O-acetyltransferase activity|acetylcarnitine transferase activity|carnitine O-acetyltransferase I activity|carnitine O-acetyltransferase II activity|carnitine acetyl coenzyme A transferase activity|carnitine acetylase activity|carnitine acetyltransferase activity|carnitine-acetyl-CoA transferase activity http://purl.obolibrary.org/obo/GO_0004092 GO:0043699 biolink:CellularComponent leucosome A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast. go.json refractosome http://purl.obolibrary.org/obo/GO_0043699 GO:0004099 biolink:MolecularActivity chitin deacetylase activity Catalysis of the reaction: chitin + H2O = chitosan + acetate. EC:3.5.1.41|MetaCyc:CHITIN-DEACETYLASE-RXN|RHEA:10464 go.json chitin amidohydrolase activity http://purl.obolibrary.org/obo/GO_0004099 GO:0004098 biolink:MolecularActivity cerebroside-sulfatase activity Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate. EC:3.1.6.8|MetaCyc:CEREBROSIDE-SULFATASE-RXN|RHEA:21300|Reactome:R-HSA-1606807|Reactome:R-HSA-9840949 go.json arylsulfatase A activity|cerebroside sulfate sulfatase activity|cerebroside-3-sulfate 3-sulfohydrolase activity|cerebroside-sulphatase activity http://purl.obolibrary.org/obo/GO_0004098 GO:0004095 biolink:MolecularActivity carnitine O-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. EC:2.3.1.21|MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN|RHEA:12661|Reactome:R-HSA-200406|Reactome:R-HSA-200410 go.json CPT|CPT I (outer membrane carnitine palmitoyl transferase)|CPT-A|CPT-B|CPTi|CPTo|L-carnitine palmitoyltransferase activity|acylcarnitine transferase activity|carnitine palmitoyltransferase I|carnitine palmitoyltransferase II|carnitine palmitoyltransferase activity|carnitine palmitoyltransferase-A|outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity|palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity|palmitoylcarnitine transferase activity http://purl.obolibrary.org/obo/GO_0004095 GO:0004094 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004094 GO:0004097 biolink:MolecularActivity catechol oxidase activity Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. EC:1.10.3.1|MetaCyc:CATECHOL-OXIDASE-RXN|RHEA:21632 go.json L-DOPA monooxygenase activity|L-dopa oxidase activity|catecholase|diphenol oxidase activity|dopamine monooxygenase activity|o-diphenol oxidoreductase|o-diphenolase activity|phenolase activity|polyphenol oxidase activity|pyrocatechol oxidase|tyrosinase activity http://purl.obolibrary.org/obo/GO_0004097 GO:0004096 biolink:MolecularActivity catalase activity Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O. EC:1.11.1.6|MetaCyc:CATAL-RXN|RHEA:20309|Reactome:R-HSA-1222704|Reactome:R-HSA-76031|UM-BBD_enzymeID:e0834 go.json CAT|bacterial catalase-peroxidase activity|caperase activity|catalase reaction|catalase-peroxidase activity|equilase activity|haem catalase activity|heme catalase activity|hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|manganese catalase activity|optidase activity http://purl.obolibrary.org/obo/GO_0004096 GO:0004069 biolink:MolecularActivity L-aspartate:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. EC:2.6.1.1|KEGG_REACTION:R00355|MetaCyc:ASPAMINOTRANS-RXN|RHEA:21824|Reactome:R-HSA-70581|Reactome:R-HSA-70592|Reactome:R-HSA-70596|Reactome:R-HSA-70613 go.json 2-oxoglutarate-glutamate aminotransferase activity|AAT|AspT|GOT (enzyme)|L-aspartate transaminase activity|L-aspartate-2-ketoglutarate aminotransferase activity|L-aspartate-2-oxoglutarate aminotransferase activity|L-aspartate-2-oxoglutarate-transaminase activity|L-aspartate-alpha-ketoglutarate transaminase activity|L-aspartic aminotransferase activity|aspartate alpha-ketoglutarate transaminase activity|aspartate aminotransferase activity|aspartate transaminase activity|aspartate-2-oxoglutarate transaminase activity|aspartate:2-oxoglutarate aminotransferase activity|aspartic acid aminotransferase activity|aspartic aminotransferase activity|aspartyl aminotransferase activity|glutamate oxaloacetate transaminase activity|glutamate-oxalacetate aminotransferase activity|glutamate-oxalate transaminase activity|glutamic oxalic transaminase activity|glutamic--aspartic transaminase activity|glutamic--oxaloacetic transaminase activity|glutamic-aspartic aminotransferase activity|glutamic-oxalacetic transaminase activity|oxaloacetate transferase activity|oxaloacetate-aspartate aminotransferase activity|transaminase A activity http://purl.obolibrary.org/obo/GO_0004069 GO:0004066 biolink:MolecularActivity asparagine synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. EC:6.3.5.4|MetaCyc:ASNSYNB-RXN|RHEA:12228|Reactome:R-HSA-70599 go.json AS|AS-B activity|L-aspartate:L-glutamine amido-ligase (AMP-forming)|asparagine synthase (glutamine-hydrolysing)|asparagine synthetase (glutamine-hydrolysing)|asparagine synthetase (glutamine-hydrolyzing) activity|asparagine synthetase B activity|glutamine-dependent asparagine synthetase activity http://purl.obolibrary.org/obo/GO_0004066 GO:0004065 biolink:MolecularActivity arylsulfatase activity Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. EC:3.1.6.1|MetaCyc:ARYLSULFAT-RXN|RHEA:17261 go.json 4-methylumbelliferyl sulfatase activity|aryl-sulfate sulfohydrolase activity|aryl-sulfate sulphohydrolase activity|aryl-sulphate sulphohydrolase activity|arylsulfohydrolase activity|arylsulphatase activity|estrogen sulfatase activity|nitrocatechol sulfatase activity|p-nitrophenyl sulfatase activity|phenolsulfatase activity|phenylsulfatase activity|sulfatase activity http://purl.obolibrary.org/obo/GO_0004065 GO:0004068 biolink:MolecularActivity aspartate 1-decarboxylase activity Catalysis of the reaction: L-aspartate = beta-alanine + CO2. EC:4.1.1.11|MetaCyc:ASPDECARBOX-RXN|MetaCyc:PWY-5155|RHEA:19497 go.json L-aspartate 1-carboxy-lyase (beta-alanine-forming)|L-aspartate 1-carboxy-lyase activity|L-aspartate alpha-decarboxylase activity|aspartate alpha-decarboxylase activity|aspartic alpha-decarboxylase http://purl.obolibrary.org/obo/GO_0004068 GO:0004067 biolink:MolecularActivity asparaginase activity Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. EC:3.5.1.1|MetaCyc:ASPARAGHYD-RXN|RHEA:21016|Reactome:R-HSA-6797627 go.json L-asparaginase activity|L-asparagine amidohydrolase activity|alpha-asparaginase activity|asparaginase II|colaspase activity|crasnitin|elspar|leunase activity http://purl.obolibrary.org/obo/GO_0004067 GO:0004062 biolink:MolecularActivity aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. EC:2.8.2.1|MetaCyc:ARYL-SULFOTRANSFERASE-RXN|RHEA:12164|Reactome:R-HSA-158468|Reactome:R-HSA-158849|Reactome:R-HSA-158860|Reactome:R-HSA-159358|Reactome:R-HSA-176474|Reactome:R-HSA-176585|Reactome:R-HSA-176646 go.json 1-naphthol phenol sulfotransferase activity|2-naphtholsulfotransferase activity|3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity|4-nitrocatechol sulfokinase activity|PST|aryl sulphotransferase activity|arylsulfotransferase|dopamine sulfotransferase activity|p-nitrophenol sulfotransferase activity|phenol sulfokinase activity|phenol sulfotransferase activity|ritodrine sulfotransferase activity|sulfokinase activity http://purl.obolibrary.org/obo/GO_0004062 goslim_chembl GO:0004061 biolink:MolecularActivity arylformamidase activity Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. EC:3.5.1.9|MetaCyc:ARYLFORMAMIDASE-RXN|RHEA:13009|Reactome:R-HSA-71189 go.json aryl-formylamine amidohydrolase activity|formamidase I|formamidase II|formylase activity|formylkynureninase activity|formylkynurenine formamidase activity|kynurenine formamidase activity http://purl.obolibrary.org/obo/GO_0004061 GO:0004064 biolink:MolecularActivity arylesterase activity Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. EC:3.1.1.2|MetaCyc:ARYLESTERASE-RXN|RHEA:17309|UM-BBD_reactionID:r0757 go.json A-esterase activity|aromatic esterase|aryl-ester hydrolase|paraoxonase activity http://purl.obolibrary.org/obo/GO_0004064 GO:0004063 biolink:MolecularActivity aryldialkylphosphatase activity Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. EC:3.1.8.1|MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN|RHEA:18053|UM-BBD_enzymeID:e0054 go.json A-esterase activity|OPH|aryltriphosphatase activity|aryltriphosphate dialkylphosphohydrolase activity|esterase B1|esterase E4|organophosphate esterase activity|organophosphate hydrolase activity|organophosphorus acid anhydrase activity|organophosphorus hydrolase activity|paraoxon esterase activity|paraoxon hydrolase activity|paraoxonase activity|phosphotriesterase activity|pirimiphos-methyloxon esterase activity http://purl.obolibrary.org/obo/GO_0004063 GO:0004071 biolink:MolecularActivity aspartate-ammonia ligase activity Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine. EC:6.3.1.1|MetaCyc:ASNSYNA-RXN|RHEA:11372 go.json L-asparagine synthetase activity|L-aspartate:ammonia ligase (AMP-forming)|asparagine synthetase activity http://purl.obolibrary.org/obo/GO_0004071 GO:0004070 biolink:MolecularActivity aspartate carbamoyltransferase activity Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate. EC:2.1.3.2|KEGG_REACTION:R01397|MetaCyc:ASPCARBTRANS-RXN|RHEA:20013|Reactome:R-HSA-73573 go.json ATCase activity|L-aspartate transcarbamoylase activity|L-aspartate transcarbamylase activity|aspartate carbamyltransferase activity|aspartate transcarbamoylase activity|aspartate transcarbamylase activity|aspartic acid transcarbamoylase activity|aspartic carbamyltransferase activity|aspartic transcarbamylase activity|carbamoyl-phosphate:L-aspartate carbamoyltransferase activity|carbamoylaspartotranskinase activity|carbamylaspartotranskinase activity http://purl.obolibrary.org/obo/GO_0004070 GO:0004077 biolink:MolecularActivity biotin-[acetyl-CoA-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). EC:6.3.4.15|MetaCyc:BIOTINLIG-RXN|RHEA:11756 go.json HCS|acetyl CoA holocarboxylase synthetase activity|acetyl coenzyme A holocarboxylase synthetase activity|acetyl-CoA carboxylase biotin holoenzyme synthetase activity|biotin holoenzyme synthetase activity|biotin--[acetyl-CoA carboxylase] synthetase activity|biotin--protein ligase activity|biotin-acetyl coenzyme A carboxylase synthetase activity|biotin-acetyl-CoA carboxylase synthetase|biotin-acetyl-CoA-carboxylase ligase activity|biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)|biotin:apocarboxylase ligase activity http://purl.obolibrary.org/obo/GO_0004077 GO:0102300 biolink:MolecularActivity linoleate 9R-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE. EC:1.13.11.61|MetaCyc:RXN-12760|RHEA:31691 go.json http://purl.obolibrary.org/obo/GO_0102300 GO:0004076 biolink:MolecularActivity biotin synthase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+. EC:2.8.1.6|KEGG_REACTION:R01078|MetaCyc:2.8.1.6-RXN|RHEA:22060 go.json biotin synthetase activity|dethiobiotin:sulfur sulfurtransferase activity http://purl.obolibrary.org/obo/GO_0004076 GO:0102302 biolink:MolecularActivity mycinamicin VI 2''-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+. EC:2.1.1.238|MetaCyc:RXN-12801|RHEA:31643 go.json http://purl.obolibrary.org/obo/GO_0102302 GO:0004079 biolink:MolecularActivity biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). EC:6.3.4.9|MetaCyc:6.3.4.9-RXN|RHEA:23668 go.json biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity|biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity|biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity|biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity|biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity|biotin-methylmalonyl-CoA-carboxyltransferase ligase activity|biotin-methylmalonyl-CoA-carboxyltransferase synthetase|biotin-methylmalonyl-CoA-carboxytransferase ligase activity|biotin-methylmalonyl-CoA-carboxytransferase synthetase activity|biotin-transcarboxylase synthetase activity|biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)|biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)|methylmalonyl coenzyme A holotranscarboxylase synthetase activity http://purl.obolibrary.org/obo/GO_0004079 GO:0004078 biolink:MolecularActivity biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). EC:6.3.4.11|MetaCyc:6.3.4.11-RXN|RHEA:24376 go.json beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity|biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity|biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity|biotin-methylcrotonoyl-CoA-carboxylase ligase activity|biotin-methylcrotonoyl-CoA-carboxylase synthetase|biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0004078 GO:0102301 biolink:MolecularActivity gamma-linolenate elongase activity Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide. MetaCyc:RXN-12777 go.json http://purl.obolibrary.org/obo/GO_0102301 GO:0102304 biolink:MolecularActivity sesquithujene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = 7-epi-sesquithujene + diphosphoric acid. EC:4.2.3.102|MetaCyc:RXN-12838|RHEA:31991 go.json http://purl.obolibrary.org/obo/GO_0102304 GO:0004073 biolink:MolecularActivity aspartate-semialdehyde dehydrogenase activity Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH. EC:1.2.1.11|KEGG_REACTION:R02291|MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN|RHEA:24284 go.json ASA dehydrogenase activity|L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)|L-aspartate-beta-semialdehyde dehydrogenase activity|L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)|aspartate semialdehyde dehydrogenase activity|aspartic beta-semialdehyde dehydrogenase activity|aspartic semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004073 GO:0102303 biolink:MolecularActivity resveratrol 3,5-O-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+. EC:2.1.1.240|MetaCyc:RXN-12805|RHEA:32103 go.json http://purl.obolibrary.org/obo/GO_0102303 GO:0004072 biolink:MolecularActivity aspartate kinase activity Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. EC:2.7.2.4|KEGG_REACTION:R00480|MetaCyc:ASPARTATEKIN-RXN|RHEA:23776 go.json ATP:L-aspartate 4-phosphotransferase activity|aspartic kinase activity|aspartokinase activity|beta-aspartokinase activity http://purl.obolibrary.org/obo/GO_0004072 GO:0004075 biolink:MolecularActivity biotin carboxylase activity Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. EC:6.3.4.14|MetaCyc:BIOTIN-CARBOXYL-RXN|RHEA:13501 go.json biotin carboxylase (component of acetyl CoA carboxylase) activity|biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity http://purl.obolibrary.org/obo/GO_0004075 GO:0102306 biolink:MolecularActivity benzil reductase [(S)-benzoin-forming] activity Catalysis of the reaction: (S)-benzoin + NADP(3-) = benzil + NADPH(4-) + H+. EC:1.1.1.320|MetaCyc:RXN-12898|RHEA:25968 go.json http://purl.obolibrary.org/obo/GO_0102306 GO:0004074 biolink:MolecularActivity biliverdin reductase (NAD(P)+) activity Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. EC:1.3.1.24|MetaCyc:BILIVERDIN-REDUCTASE-RXN|Reactome:R-HSA-189384 go.json bilirubin:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004074 GO:0102305 biolink:MolecularActivity (13E)-labda-7,13-dien-15-ol synthase activity Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphoric acid. EC:3.1.7.10|MetaCyc:RXN-12892|RHEA:32075 go.json http://purl.obolibrary.org/obo/GO_0102305 GO:0004080 biolink:MolecularActivity biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)). EC:6.3.4.10|MetaCyc:6.3.4.10-RXN|RHEA:11204 go.json biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity|biotin-propionyl coenzyme A carboxylase synthetase activity|biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity|biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity|biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)|holocarboxylase synthetase activity|propionyl coenzyme A holocarboxylase synthetase activity|propionyl-CoA holocarboxylase synthetase activity http://purl.obolibrary.org/obo/GO_0004080 GO:0102308 biolink:MolecularActivity erythromycin D 3''-o-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B + H+. EC:2.1.1.254|MetaCyc:RXN-12924|RHEA:32651 go.json http://purl.obolibrary.org/obo/GO_0102308 GO:0102307 biolink:MolecularActivity erythromycin C 3''-o-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A + H+. EC:2.1.1.254|MetaCyc:RXN-12923|RHEA:32647 go.json http://purl.obolibrary.org/obo/GO_0102307 GO:0004082 biolink:MolecularActivity bisphosphoglycerate mutase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. EC:5.4.2.4|MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN|RHEA:17765|Reactome:R-HSA-6798335 go.json 2,3-bisphosphoglycerate mutase activity|2,3-bisphosphoglycerate synthase activity|2,3-diphosphoglycerate mutase activity|2,3-diphosphoglycerate synthase activity|2,3-diphosphoglyceromutase activity|3-phospho-D-glycerate 1,2-phosphomutase activity|BPGM activity|DPGM|biphosphoglycerate synthase activity|bisphosphoglycerate synthase activity|bisphosphoglyceromutase|diphosphoglycerate mutase activity|diphosphoglyceric mutase activity|diphosphoglyceromutase activity|glycerate phosphomutase activity http://purl.obolibrary.org/obo/GO_0004082 GO:0004081 biolink:MolecularActivity bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. EC:3.6.1.17|MetaCyc:3.6.1.17-RXN|RHEA:22484|Reactome:R-HSA-5696197 go.json 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity|Ap(4)A hydrolase activity|Ap(4)Aase activity|Ap4A hydrolase activity|Ap4Aase activity|P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity|bis(5'-adenosyl)-tetraphosphatase activity|bis(5'-guanosyl)-tetraphosphatase activity|diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity|diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity|diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase|diadenosine P1,P4-tetraphosphatase activity|diadenosinetetraphosphatase (asymmetrical) activity|diguanosinetetraphosphatase (asymmetrical) activity|dinucleoside tetraphosphatase activity|dinucleosidetetraphosphatase (asymmetrical) activity http://purl.obolibrary.org/obo/GO_0004081 GO:0102309 biolink:MolecularActivity obsolete dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity OBSOLETE. Catalysis of the reaction: dTDP-D-oliose + NADP = dTDP-4-dehydro-2,6-dideoxy-D-glucose + NADPH + H+. MetaCyc:RXN-12930 go.json True http://purl.obolibrary.org/obo/GO_0102309 GO:0018690 biolink:MolecularActivity 4-methoxybenzoate monooxygenase (O-demethylating) activity Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O. EC:1.14.99.15|KEGG_REACTION:R01306|MetaCyc:1.14.99.15-RXN|RHEA:18613|UM-BBD_reactionID:r0154 go.json 4-methoxybenzoate 4-monooxygenase (O-demethylating)|4-methoxybenzoate O-demethylase activity|4-methoxybenzoate monooxygenase activity|4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)|p-anisic O-demethylase activity|piperonylate-4-O-demethylase activity http://purl.obolibrary.org/obo/GO_0018690 GO:0004048 biolink:MolecularActivity anthranilate phosphoribosyltransferase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. EC:2.4.2.18|KEGG_REACTION:R01073|MetaCyc:PRTRANS-RXN|RHEA:11768 go.json N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity|PRT|anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity|anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity|anthranilate-PP-ribose-P phosphoribosyltransferase activity|phosphoribosyl-anthranilate diphosphorylase activity|phosphoribosyl-anthranilate pyrophosphorylase activity|phosphoribosylanthranilate pyrophosphorylase activity|phosphoribosylanthranilate transferase activity http://purl.obolibrary.org/obo/GO_0004048 GO:0004047 biolink:MolecularActivity aminomethyltransferase activity Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. EC:2.1.2.10|MetaCyc:GCVT-RXN|RHEA:16945|Reactome:R-HSA-5693977 go.json S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity|T-protein|glycine synthase activity|glycine-cleavage system T-protein activity|protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity|protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity|tetrahydrofolate aminomethyltransferase activity http://purl.obolibrary.org/obo/GO_0004047 GO:0004049 biolink:MolecularActivity anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. EC:4.1.3.27|MetaCyc:ANTHRANSYN-RXN|RHEA:21732 go.json anthranilate synthetase activity|chorismate pyruvate-lyase (amino-accepting) activity http://purl.obolibrary.org/obo/GO_0004049 GO:0004044 biolink:MolecularActivity amidophosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. EC:2.4.2.14|KEGG_REACTION:R01072|MetaCyc:PRPPAMIDOTRANS-RXN|RHEA:14905|Reactome:R-HSA-73815 go.json 5'-phosphoribosylpyrophosphate amidotransferase activity|5-phosphoribosyl-1-pyrophosphate amidotransferase activity|5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)|5-phosphororibosyl-1-pyrophosphate amidotransferase activity|alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity|glutamine 5-phosphoribosylpyrophosphate amidotransferase activity|glutamine phosphoribosyldiphosphate amidotransferase activity|glutamine phosphoribosylpyrophosphate amidotransferase activity|glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity|phosphoribose pyrophosphate amidotransferase activity|phosphoribosyl pyrophosphate amidotransferase activity|phosphoribosyldiphosphate 5-amidotransferase activity|phosphoribosylpyrophosphate glutamyl amidotransferase activity http://purl.obolibrary.org/obo/GO_0004044 GO:0004043 biolink:MolecularActivity L-aminoadipate-semialdehyde dehydrogenase activity Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. EC:1.2.1.31|MetaCyc:1.2.1.31-RXN|RHEA:12308|Reactome:R-HSA-70941 go.json 2-aminoadipate semialdehyde dehydrogenase activity|2-aminoadipic semialdehyde dehydrogenase activity|AAR|L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase|L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity|L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity|L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity|alpha-aminoadipate reductase activity|alpha-aminoadipate-semialdehyde dehydrogenase activity|aminoadipate semialdehyde dehydrogenase activity|aminoadipate-semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004043 GO:0004046 biolink:MolecularActivity aminoacylase activity Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. EC:3.5.1.14|MetaCyc:AMINOACYLASE-RXN|RHEA:15565|Reactome:R-HSA-5433074|Reactome:R-HSA-5579081|Reactome:R-HSA-9638046|Reactome:R-HSA-9753944 go.json L-amino-acid acylase activity|L-aminoacylase activity|N-acyl-L-amino-acid amidohydrolase activity|acylase I activity|alpha-N-acylaminoacid hydrolase activity|amido acid deacylase activity|aminoacylase I activity|benzamidase activity|dehydropeptidase II activity|hippurase activity|histozyme activity|long acyl amidoacylase activity|short acyl amidoacylase activity http://purl.obolibrary.org/obo/GO_0004046 GO:0004045 biolink:MolecularActivity aminoacyl-tRNA hydrolase activity Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. EC:3.1.1.29|MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN|RHEA:54448 go.json D-tyrosyl-tRNA hydrolase activity|N-substituted aminoacyl transfer RNA hydrolase activity|aminoacyl-tRNA aminoacylhydrolase activity|aminoacyl-tRNA hydrolase reaction|aminoacyl-transfer ribonucleate hydrolase activity|peptidyl-tRNA hydrolase activity http://purl.obolibrary.org/obo/GO_0004045 GO:0004040 biolink:MolecularActivity amidase activity Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. EC:3.5.1.4|MetaCyc:AMIDASE-RXN|RHEA:12020|UM-BBD_enzymeID:e0068 go.json N-acetylaminohydrolase activity|acetamidase activity|acylamidase activity|acylamide amidohydrolase activity|acylase activity|amidohydrolase activity|fatty acylamidase activity http://purl.obolibrary.org/obo/GO_0004040 GO:0004042 biolink:MolecularActivity acetyl-CoA:L-glutamate N-acetyltransferase activity Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. EC:2.3.1.1|KEGG_REACTION:R00259|MetaCyc:N-ACETYLTRANSFER-RXN|RHEA:24292|Reactome:R-HSA-70542 go.json AGAS|N-acetylglutamate synthase activity|acetylglutamate acetylglutamate synthetase activity|amino acid acetyltransferase activity|amino-acid N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004042 GO:0004041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004041 GO:0018689 biolink:MolecularActivity naphthalene disulfonate 1,2-dioxygenase activity Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene). UM-BBD_enzymeID:e0249 go.json naphthalene disulphonate 1,2-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018689 GO:0018688 biolink:MolecularActivity DDT 2,3-dioxygenase activity Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT. UM-BBD_reactionID:r0450 go.json http://purl.obolibrary.org/obo/GO_0018688 GO:0018685 biolink:MolecularActivity alkane 1-monooxygenase activity Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. EC:1.14.15.3|MetaCyc:ALKANE-1-MONOOXYGENASE-RXN|RHEA:19341|UM-BBD_enzymeID:e0022 go.json 1-hydroxylase activity|alkane 1-hydroxylase activity|alkane hydroxylase activity|alkane monooxygenase activity|alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity|fatty acid (omega-1)-hydroxylase activity|fatty acid omega-hydroxylase activity|lauric acid omega-hydroxylase activity|omega-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018685 GO:0018684 biolink:MolecularActivity 2,5-diketocamphane 1,2-monooxygenase Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O. EC:1.14.14.108|MetaCyc:R543-RXN|RHEA:34415|UM-BBD_enzymeID:e0302 go.json (+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)|2,5-diketocamphane lactonizing enzyme activity|camphor 1,2-monooxygenase activity|camphor ketolactonase I activity http://purl.obolibrary.org/obo/GO_0018684 GO:0018687 biolink:MolecularActivity biphenyl 2,3-dioxygenase activity Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+. EC:1.14.12.18|MetaCyc:1.14.12.18-RXN|RHEA:18165|UM-BBD_enzymeID:e0089 go.json biphenyl dioxygenase activity|biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating) http://purl.obolibrary.org/obo/GO_0018687 GO:0018686 biolink:MolecularActivity 6-hydroxy pseudo-oxynicotine monooxygenase activity Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine. EC:1.14.18.-|UM-BBD_reactionID:r0480 go.json http://purl.obolibrary.org/obo/GO_0018686 GO:0018681 biolink:MolecularActivity deisopropylatrazine monooxygenase activity Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine. EC:1.14.15.-|KEGG_REACTION:R05567 go.json http://purl.obolibrary.org/obo/GO_0018681 GO:0018680 biolink:MolecularActivity deethylatrazine monooxygenase activity Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine. EC:1.14.15.-|UM-BBD_reactionID:r0128 go.json http://purl.obolibrary.org/obo/GO_0018680 GO:0018683 biolink:MolecularActivity camphor 5-monooxygenase activity Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O. EC:1.14.15.1|MetaCyc:R541-RXN|RHEA:13525|UM-BBD_enzymeID:e0300 go.json (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)|2-bornanone 5-exo-hydroxylase activity|D-camphor-exo-hydroxylase activity|bornanone 5-exo-hydroxylase activity|camphor 5-exo-hydroxylase activity|camphor 5-exo-methylene hydroxylase activity|camphor 5-exohydroxylase activity|camphor hydroxylase activity|camphor methylene hydroxylase activity|cytochrome p450-cam activity|d-camphor monooxygenase activity|methylene hydroxylase activity|methylene monooxygenase activity http://purl.obolibrary.org/obo/GO_0018683 GO:0018682 biolink:MolecularActivity atrazine N-dealkylase activity Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O. EC:1.14.15.-|MetaCyc:R461-RXN|UM-BBD_reactionID:r0127 go.json atrazine monooxygenase activity http://purl.obolibrary.org/obo/GO_0018682 GO:0004059 biolink:MolecularActivity aralkylamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine. EC:2.3.1.87|MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN|RHEA:20497|Reactome:R-HSA-209792 go.json AANAT activity|acetyl-CoA:2-arylethylamine N-acetyltransferase activity|arylalkylamine N-acetyltransferase activity|melatonin rhythm enzyme activity|serotonin N-acetyltransferase activity|serotonin acetylase activity|serotonin acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004059 GO:0004058 biolink:MolecularActivity aromatic-L-amino-acid decarboxylase activity Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. EC:4.1.1.28|MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN|Reactome:R-HSA-209859|Reactome:R-HSA-209924 go.json 5-hydroxytryptophan decarboxylase activity|DOPA decarboxylase activity|L-DOPA decarboxylase activity|aromatic amino acid decarboxylase activity|aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)|aromatic-L-amino-acid carboxy-lyase activity|hydroxytryptophan decarboxylase activity|tryptophan decarboxylase activity http://purl.obolibrary.org/obo/GO_0004058 GO:0004055 biolink:MolecularActivity argininosuccinate synthase activity Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. EC:6.3.4.5|MetaCyc:ARGSUCCINSYN-RXN|RHEA:10932|Reactome:R-HSA-70577 go.json L-citrulline:L-aspartate ligase (AMP-forming)|arginine succinate synthetase activity|argininosuccinate synthetase activity|argininosuccinic acid synthetase activity|arginosuccinate synthetase activity|citrulline--aspartate ligase activity http://purl.obolibrary.org/obo/GO_0004055 GO:0004054 biolink:MolecularActivity arginine kinase activity Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+. EC:2.7.3.3|KEGG_REACTION:R00554|MetaCyc:ARGININE-KINASE-RXN|RHEA:22940 go.json ATP:L-arginine N-phosphotransferase activity|adenosine 5'-triphosphate-arginine phosphotransferase activity|adenosine 5'-triphosphate:L-arginine|arginine phosphokinase activity http://purl.obolibrary.org/obo/GO_0004054 GO:0004057 biolink:MolecularActivity arginyl-tRNA--protein transferase activity Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg). EC:2.3.2.8|MetaCyc:ARGINYLTRANSFERASE-RXN|RHEA:10208 go.json arginine transferase activity|arginyl-tRNA protein transferase activity|arginyltransferase activity http://purl.obolibrary.org/obo/GO_0004057 GO:0004056 biolink:MolecularActivity argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. EC:4.3.2.1|MetaCyc:ARGSUCCINLYA-RXN|RHEA:24020|Reactome:R-HSA-70573 go.json 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)|2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)|N-(L-argininosuccinate) arginine-lyase activity|arginine-succinate lyase activity|argininosuccinic acid lyase activity|arginosuccinase activity|omega-N-(L-arginino)succinate arginine-lyase activity http://purl.obolibrary.org/obo/GO_0004056 GO:0004051 biolink:MolecularActivity arachidonate 5-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. EC:1.13.11.34|MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN|RHEA:32307|Reactome:R-HSA-265296|Reactome:R-HSA-266051|Reactome:R-HSA-9018858|Reactome:R-HSA-9018859|Reactome:R-HSA-9018863|Reactome:R-HSA-9018894|Reactome:R-HSA-9020251|Reactome:R-HSA-9020255|Reactome:R-HSA-9020256|Reactome:R-HSA-9020259|Reactome:R-HSA-9020264|Reactome:R-HSA-9020277|Reactome:R-HSA-9020278|Reactome:R-HSA-9020282|Reactome:R-HSA-9024997|Reactome:R-HSA-9025995|Reactome:R-HSA-9025996|Reactome:R-HSA-9025999|Reactome:R-HSA-9026005|Reactome:R-HSA-9026405|Reactome:R-HSA-9027624|Reactome:R-HSA-9027628|Reactome:R-HSA-9027633 go.json 5-delta-lipoxygenase activity|5-lipoxygenase activity|5Delta-lipoxygenase activity|C-5-lipoxygenase activity|LTA synthase activity|arachidonate:oxygen 5-oxidoreductase activity|arachidonic 5-lipoxygenase activity|arachidonic acid 5-lipoxygenase activity|delta(5)-lipoxygenase activity|delta5-lipoxygenase activity|leukotriene A4 synthase|leukotriene-A(4) synthase activity|leukotriene-A4 synthase activity http://purl.obolibrary.org/obo/GO_0004051 GO:0004050 biolink:MolecularActivity obsolete apyrase activity OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate. go.json apyrase activity True http://purl.obolibrary.org/obo/GO_0004050 GO:0004053 biolink:MolecularActivity arginase activity Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. EC:3.5.3.1|MetaCyc:ARGINASE-RXN|RHEA:20569|Reactome:R-HSA-452036|Reactome:R-HSA-70569 go.json L-arginase activity|L-arginine amidinohydrolase activity|arginine amidinase activity|arginine transamidinase activity|canavanase activity http://purl.obolibrary.org/obo/GO_0004053 GO:0004052 biolink:MolecularActivity arachidonate 12(S)-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. EC:1.13.11.31|KEGG_REACTION:R01596|MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN|RHEA:10428|Reactome:R-HSA-2161948|Reactome:R-HSA-2161950|Reactome:R-HSA-2161964|Reactome:R-HSA-9024983|Reactome:R-HSA-9025957|Reactome:R-HSA-9026006|Reactome:R-HSA-9026007 go.json 12-lipoxygenase activity|12Delta-lipoxygenase activity|12S-lipoxygenase activity|C-12 lipoxygenase activity|LTA4 synthase activity|arachidonate:oxygen 12-oxidoreductase activity|delta12-lipoxygenase activity|leukotriene A4 synthase http://purl.obolibrary.org/obo/GO_0004052 GO:0004060 biolink:MolecularActivity arylamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. EC:2.3.1.5|MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN|RHEA:16613|Reactome:R-HSA-174963|Reactome:R-HSA-174967|Reactome:R-HSA-9753676|UM-BBD_enzymeID:e0341 go.json 2-naphthylamine N-acetyltransferase activity|4-aminobiphenyl N-acetyltransferase activity|acetyl CoA-arylamine N-acetyltransferase activity|acetyl-CoA:arylamine N-acetyltransferase activity|arylamine acetylase activity|arylamine acetyltransferase activity|beta-naphthylamine N-acetyltransferase activity|indoleamine N-acetyltransferase activity|p-aminosalicylate N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004060 GO:0018699 biolink:MolecularActivity 1,1,1-trichloroethane reductive dehalogenase activity Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl. EC:1.97.1.-|UM-BBD_reactionID:r1007 go.json http://purl.obolibrary.org/obo/GO_0018699 GO:0018696 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018696 GO:0018695 biolink:MolecularActivity 4-cresol dehydrogenase (hydroxylating) activity Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor. EC:1.17.9.1|MetaCyc:1.17.99.1-RXN|RHEA:15141|UM-BBD_reactionID:r0272 go.json 4-cresol dehydrogenase activity|4-cresol:acceptor oxidoreductase (methyl-hydroxylating)|p-cresol methylhydroxylase activity|p-cresol-(acceptor) oxidoreductase (hydroxylating) activity http://purl.obolibrary.org/obo/GO_0018695 GO:0018698 biolink:MolecularActivity vinyl chloride reductive dehalogenase activity Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene. EC:1.97.1.-|MetaCyc:VCREDCHLOR-RXN|UM-BBD_reactionID:r0352 go.json http://purl.obolibrary.org/obo/GO_0018698 GO:0018697 biolink:MolecularActivity carbonyl sulfide nitrogenase activity Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide. EC:1.18.6.1|UM-BBD_reactionID:r0600 go.json carbonyl sulphide nitrogenase activity http://purl.obolibrary.org/obo/GO_0018697 GO:0018692 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018692 GO:0018691 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018691 GO:0018694 biolink:MolecularActivity p-cymene methyl hydroxylase activity Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol. EC:1.14.15.25|MetaCyc:RXN-661|RHEA:51604|UM-BBD_reactionID:r0392 go.json http://purl.obolibrary.org/obo/GO_0018694 GO:0018693 biolink:MolecularActivity ethylbenzene hydroxylase activity Catalysis of the reaction: A + ethylbenzene + H2O = (S)-1-phenylethanol + AH(2). EC:1.17.99.2|KEGG_REACTION:R05745|MetaCyc:RXN-1301|RHEA:17897|UM-BBD_reactionID:r0234 go.json ethylbenzene dehydrogenase activity|ethylbenzene:(acceptor) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018693 GO:0004029 biolink:MolecularActivity aldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. EC:1.2.1.3|MetaCyc:ALDHDEHYDROG-RXN|RHEA:16185|Reactome:R-HSA-380608|Reactome:R-HSA-389609|Reactome:R-HSA-5692261|Reactome:R-HSA-5696091|Reactome:R-HSA-6808487|Reactome:R-HSA-6808496|Reactome:R-HSA-6813749|Reactome:R-HSA-71691|Reactome:R-HSA-71723|UM-BBD_enzymeID:e0024|Wikipedia:Aldehyde_dehydrogenase_(NAD+) go.json CoA-independent aldehyde dehydrogenase activity|NAD-aldehyde dehydrogenase activity|NAD-dependent 4-hydroxynonenal dehydrogenase activity|NAD-dependent aldehyde dehydrogenase activity|NAD-linked aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+)|aldehyde:NAD+ oxidoreductase activity|m-methylbenzaldehyde dehydrogenase activity|propionaldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004029 GO:0004026 biolink:MolecularActivity alcohol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester. EC:2.3.1.84|MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN|RHEA:17229 go.json AATASE activity|acetyl-CoA:alcohol O-acetyltransferase activity|alcohol acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004026 GO:0004025 biolink:MolecularActivity alcohol dehydrogenase activity, iron-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron. go.json http://purl.obolibrary.org/obo/GO_0004025 GO:0004028 biolink:MolecularActivity 3-chloroallyl aldehyde dehydrogenase activity Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. UM-BBD_enzymeID:e0432 go.json http://purl.obolibrary.org/obo/GO_0004028 GO:0004027 biolink:MolecularActivity alcohol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. EC:2.8.2.2|MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN|RHEA:22552|Reactome:R-HSA-176494|Reactome:R-HSA-176609 go.json 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity|3-hydroxysteroid sulfotransferase activity|3beta-hydroxy steroid sulfotransferase activity|3beta-hydroxysteroid sulfotransferase activity|5alpha-androstenol sulfotransferase activity|HST|alcohol sulphotransferase activity|alcohol/hydroxysteroid sulfotransferase activity|dehydroepiandrosterone sulfotransferase activity|delta5-3beta-hydroxysteroid sulfokinase activity|estrogen sulfokinase activity|estrogen sulfotransferase|hydroxysteroid sulfotransferase activity|steroid alcohol sulfotransferase|steroid sulfokinase activity|sterol sulfokinase activity|sterol sulfotransferase activity http://purl.obolibrary.org/obo/GO_0004027 goslim_chembl GO:0004022 biolink:MolecularActivity alcohol dehydrogenase (NAD+) activity Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. EC:1.1.1.1|MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN|RHEA:10740|Reactome:R-HSA-2162078|UM-BBD_enzymeID:e0023 go.json ADH|NAD-dependent alcohol dehydrogenase|NAD-specific aromatic alcohol dehydrogenase|NADH-alcohol dehydrogenase|NADH-aldehyde dehydrogenase|alcohol dehydrogenase activity|alcohol:NAD+ oxidoreductase|aldehyde dehydrogenase (NAD) activity|aldo-keto reductase (NAD) activity|aliphatic alcohol dehydrogenase|ethanol dehydrogenase|primary alcohol dehydrogenase|yeast alcohol dehydrogenase http://purl.obolibrary.org/obo/GO_0004022 GO:0004021 biolink:MolecularActivity L-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. EC:2.6.1.2|KEGG_REACTION:R00258|MetaCyc:ALANINE-AMINOTRANSFERASE-RXN|RHEA:19453|Reactome:R-HSA-507749|Reactome:R-HSA-507775|Reactome:R-HSA-70523|Reactome:R-HSA-70524 go.json ALT|GPT|L-alanine aminotransferase activity|L-alanine transaminase activity|L-alanine-alpha-ketoglutarate aminotransferase activity|alanine aminotransferase activity|alanine transaminase activity|alanine-alpha-ketoglutarate aminotransferase activity|alanine-pyruvate aminotransferase activity|beta-alanine aminotransferase|glutamic acid-pyruvic acid transaminase activity|glutamic--alanine transaminase activity|glutamic--pyruvic transaminase activity|glutamic-pyruvic aminotransferase activity|pyruvate transaminase activity|pyruvate-alanine aminotransferase activity|pyruvate-glutamate transaminase activity http://purl.obolibrary.org/obo/GO_0004021 GO:0004024 biolink:MolecularActivity alcohol dehydrogenase activity, zinc-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. Reactome:R-HSA-71707 go.json http://purl.obolibrary.org/obo/GO_0004024 GO:0004023 biolink:MolecularActivity alcohol dehydrogenase activity, metal ion-independent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion. go.json http://purl.obolibrary.org/obo/GO_0004023 GO:0004020 biolink:MolecularActivity adenylylsulfate kinase activity Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. EC:2.7.1.25|MetaCyc:ADENYLYLSULFKIN-RXN|RHEA:24152|Reactome:R-HSA-174389|Reactome:R-HSA-3560785 go.json 5'-phosphoadenosine sulfate kinase activity|APS kinase activity|ATP:adenylyl-sulfate 3'-phosphotransferase activity|adenosine 5'-phosphosulfate kinase activity|adenosine phosphosulfate kinase activity|adenosine phosphosulfokinase activity|adenosine-5'-phosphosulfate 3'-phosphotransferase activity|adenosine-5'-phosphosulfate-3'-phosphokinase activity|adenosine-5'-phosphosulphate 3'-phosphotransferase activity|adenylyl-sulfate kinase activity|adenylyl-sulphate kinase activity|adenylylsulfate kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004020 GO:0018667 biolink:MolecularActivity cyclohexanone monooxygenase activity Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O. EC:1.14.13.22|MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN|RHEA:24068|UM-BBD_reactionID:r0166 go.json cyclohexanone 1,2-monooxygenase activity|cyclohexanone oxygenase activity|cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity|cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming) http://purl.obolibrary.org/obo/GO_0018667 GO:0018666 biolink:MolecularActivity 2,4-dichlorophenol 6-monooxygenase activity Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O. EC:1.14.13.20|MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN|RHEA:20920|UM-BBD_enzymeID:e0152 go.json 2,4-dichlorophenol hydroxylase activity|2,4-dichlorophenol monooxygenase activity|2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating) http://purl.obolibrary.org/obo/GO_0018666 GO:0018669 biolink:MolecularActivity 3-hydroxybenzoate 6-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+. EC:1.14.13.24|KEGG_REACTION:R02589|MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN|RHEA:22692|UM-BBD_reactionID:r0402 go.json 3-hydroxybenzoate 6-hydroxylase activity|3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)|3-hydroxybenzoic acid-6-hydroxylase activity|m-hydroxybenzoate 6-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018669 GO:0018668 biolink:MolecularActivity 3-hydroxybenzoate 4-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+. EC:1.14.13.23|KEGG_REACTION:R01628|MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN|RHEA:11480|UM-BBD_reactionID:r0153 go.json 3-hydroxybenzoate 4-hydroxylase activity|3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating) http://purl.obolibrary.org/obo/GO_0018668 GO:0018663 biolink:MolecularActivity 2,6-dihydroxypyridine 3-monooxygenase activity Catalysis of the reaction: 2,6-dihydroxypyridine + H+ + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD+. EC:1.14.13.10|KEGG_REACTION:R04130|MetaCyc:1.14.13.10-RXN|RHEA:16917|UM-BBD_reactionID:r0479 go.json 2,6-dihydroxypyridine oxidase activity|2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating) http://purl.obolibrary.org/obo/GO_0018663 GO:0018662 biolink:MolecularActivity phenol 2-monooxygenase activity Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O. EC:1.14.13.7|MetaCyc:PHENOL-2-MONOOXYGENASE-RXN|RHEA:17061|UM-BBD_enzymeID:e0208 go.json phenol hydroxylase activity|phenol o-hydroxylase activity|phenol,NADPH:oxygen oxidoreductase (2-hydroxylating) http://purl.obolibrary.org/obo/GO_0018662 GO:0018665 biolink:MolecularActivity 4-hydroxyphenylacetate 1-monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O. EC:1.14.13.18|MetaCyc:1.14.13.18-RXN|UM-BBD_reactionID:r0300 go.json 4-HPA 1-hydroxylase activity|4-hydroxyphenyl-acetate 1-hydroxylase activity|4-hydroxyphenylacetate 1-hydroxylase activity|4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)|4-hydroxyphenylacetic 1-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018665 GO:0018664 biolink:MolecularActivity benzoate 4-monooxygenase activity Catalysis of the reaction: benzoate + H+ + NADPH + O2 = 4-hydroxybenzoate + H2O + NADP+. EC:1.14.14.92|KEGG_REACTION:R01295|MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN|RHEA:18033|UM-BBD_reactionID:r0623 go.json 4-hydroxybenzoic hydroxylase activity|benzoate 4-hydroxylase activity|benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)|benzoate-p-hydroxylase activity|benzoate-para-hydroxylase activity|benzoic 4-hydroxylase activity|benzoic acid 4-hydroxylase activity|p-hydroxybenzoate hydroxylase activity http://purl.obolibrary.org/obo/GO_0018664 GO:0018661 biolink:MolecularActivity orcinol 2-monooxygenase activity Catalysis of the reaction: H+ + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD+. EC:1.14.13.6|KEGG_REACTION:R02830|MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN|RHEA:19601|UM-BBD_reactionID:r0092 go.json orcinol hydroxylase activity|orcinol,NADH:oxygen oxidoreductase (2-hydroxylating) http://purl.obolibrary.org/obo/GO_0018661 GO:0018660 biolink:MolecularActivity obsolete 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity OBSOLETE. Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O. KEGG_REACTION:R02698 go.json 4 HPA 3-hydroxylase activity|4-hydroxyphenylacetate 3-hydroxylase activity|4-hydroxyphenylacetate 3-monooxygenase activity|p-hydroxyphenylacetate 3-hydroxylase activity|p-hydroxyphenylacetate hydroxylase activity True http://purl.obolibrary.org/obo/GO_0018660 GO:0004037 biolink:MolecularActivity allantoicase activity Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea. EC:3.5.3.4|KEGG_REACTION:R02422|MetaCyc:ALLANTOICASE-RXN|RHEA:11016 go.json allantoate amidinohydrolase activity|allantoine amidinohydrolase activity http://purl.obolibrary.org/obo/GO_0004037 GO:0004036 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004036 GO:0004039 biolink:MolecularActivity allophanate hydrolase activity Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4. EC:3.5.1.54|KEGG_REACTION:R00005|MetaCyc:ALLOPHANATE-HYDROLASE-RXN|RHEA:19029|UM-BBD_reactionID:r0848 go.json allophanate lyase activity|urea-1-carboxylate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0004039 GO:0004038 biolink:MolecularActivity allantoinase activity Catalysis of the reaction: allantoin + H2O = allantoate. EC:3.5.2.5|MetaCyc:ALLANTOINASE-RXN|RHEA:17029 go.json (S)-allantoin amidohydrolase activity http://purl.obolibrary.org/obo/GO_0004038 GO:0004033 biolink:MolecularActivity aldo-keto reductase (NADP) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. Reactome:R-HSA-192033|Reactome:R-HSA-192036|Reactome:R-HSA-192067|Reactome:R-HSA-192160|Reactome:R-HSA-193746|Reactome:R-HSA-193755|Reactome:R-HSA-193758|Reactome:R-HSA-193781|Reactome:R-HSA-193800|Reactome:R-HSA-193821|Reactome:R-HSA-193824|Reactome:R-HSA-193841|Reactome:R-HSA-198845|Reactome:R-HSA-2855252|Reactome:R-HSA-5423637|Reactome:R-HSA-5692232|Reactome:R-HSA-9027531|Reactome:R-HSA-9027562|Reactome:R-HSA-9027598|Reactome:R-HSA-9027600 go.json NADPH-dependent aldo-keto reductase activity|alcohol dehydrogenase (NADP+) activity|aldo-keto reductase (NADP+) activity|aldo-keto reductase activity http://purl.obolibrary.org/obo/GO_0004033 GO:0004032 biolink:MolecularActivity alditol:NADP+ 1-oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. EC:1.1.1.21|KEGG_REACTION:R02820|MetaCyc:ALDEHYDE-REDUCTASE-RXN|RHEA:12789|Reactome:R-HSA-196060|Reactome:R-HSA-5652172 go.json aldehyde reductase activity|aldose reductase activity|polyol dehydrogenase (NADP(+)) activity http://purl.obolibrary.org/obo/GO_0004032 GO:0004035 biolink:MolecularActivity alkaline phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. EC:3.1.3.1|MetaCyc:ALKAPHOSPHA-RXN|Reactome:R-HSA-8878787 go.json alkaline phenyl phosphatase activity|alkaline phosphohydrolase activity|alkaline phosphomonoesterase activity|glycerophosphatase activity|orthophosphoric-monoester phosphohydrolase (alkaline optimum)|phosphate-monoester phosphohydrolase (alkaline optimum)|phosphomonoesterase activity http://purl.obolibrary.org/obo/GO_0004035 GO:0004034 biolink:MolecularActivity aldose 1-epimerase activity Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. EC:5.1.3.3|MetaCyc:ALDOSE-1-EPIMERASE-RXN|RHEA:10264 go.json aldose mutarotase activity|mutarotase activity http://purl.obolibrary.org/obo/GO_0004034 GO:0004031 biolink:MolecularActivity aldehyde oxidase activity Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. EC:1.2.3.1|MetaCyc:ALDEHYDE-OXIDASE-RXN|MetaCyc:RXN-8093|MetaCyc:RXN-8094|RHEA:16829|Reactome:R-HSA-3204311 go.json aldehyde:oxygen oxidoreductase activity|quinoline oxidase activity|retinal oxidase activity http://purl.obolibrary.org/obo/GO_0004031 GO:0004030 biolink:MolecularActivity aldehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. EC:1.2.1.5|MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN|Reactome:R-HSA-5692283|Reactome:R-HSA-5696080|Reactome:R-HSA-6808464 go.json ALDH|aldehyde:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004030 GO:0018678 biolink:MolecularActivity 4-hydroxybenzoate 1-hydroxylase activity Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2. EC:1.14.13.64|MetaCyc:1.14.13.64-RXN|UM-BBD_reactionID:r0752 go.json 4-hydroxybenzoate 1-monooxygenase activity|4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating) http://purl.obolibrary.org/obo/GO_0018678 GO:0018677 biolink:MolecularActivity pentachlorophenol monooxygenase activity Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride. EC:1.14.13.50|MetaCyc:PCP4MONO-RXN|RHEA:18685|UM-BBD_enzymeID:e0148 go.json PCB 4-monooxygenase activity|PCB4MO activity|PCP hydroxylase activity|PcpB|pentachlorophenol 4-monooxygenase activity|pentachlorophenol dechlorinase activity|pentachlorophenol dehalogenase activity|pentachlorophenol hydroxylase activity|pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating) http://purl.obolibrary.org/obo/GO_0018677 GO:0018679 biolink:MolecularActivity dibenzothiophene-5,5-dioxide monooxygenase activity Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate. EC:1.14.14.-|MetaCyc:RXN-623|UM-BBD_reactionID:r0235 go.json http://purl.obolibrary.org/obo/GO_0018679 GO:0018674 biolink:MolecularActivity (S)-limonene 3-monooxygenase activity Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (1S,6R)-isopiperitenol + H2O + NADP+. EC:1.14.14.99|KEGG_REACTION:R02469|MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN|RHEA:15129|UM-BBD_reactionID:r0739 go.json (-)-limonene 3-hydroxylase activity|(-)-limonene 3-monooxygenase activity|(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity|(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)|limonene 3-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018674 GO:0018673 biolink:MolecularActivity anthraniloyl-CoA monooxygenase activity Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+. EC:1.14.13.40|MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0568 go.json 2-aminobenzoyl-CoA monooxygenase/reductase activity|2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)|anthraniloyl coenzyme A reductase activity http://purl.obolibrary.org/obo/GO_0018673 GO:0018676 biolink:MolecularActivity (S)-limonene 7-monooxygenase activity Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (4S)-perillyl alcohol + H2O + NADP+. EC:1.14.14.52|KEGG_REACTION:R02470|MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN|RHEA:23432|UM-BBD_reactionID:r0728 go.json (-)-limonene 7-monooxygenase activity http://purl.obolibrary.org/obo/GO_0018676 GO:0018675 biolink:MolecularActivity (S)-limonene 6-monooxygenase activity Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. EC:1.14.14.51|MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN|RHEA:17945|UM-BBD_reactionID:r0713 go.json (-)-limonene 6-hydroxylase activity|(-)-limonene 6-monooxygenase activity|(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity|(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)|limonene 6-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018675 GO:0018670 biolink:MolecularActivity 4-aminobenzoate 1-monooxygenase activity Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2. EC:1.14.13.27|MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0597 go.json 4-aminobenzoate dehydrogenase activity|4-aminobenzoate hydroxylase activity|4-aminobenzoate monooxygenase activity|4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating) http://purl.obolibrary.org/obo/GO_0018670 GO:0018672 biolink:MolecularActivity anthranilate 3-monooxygenase (deaminating) activity Catalysis of the reaction: anthranilate + 2 H+ + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH4. EC:1.14.13.35|KEGG_REACTION:R00980|MetaCyc:1.14.13.35-RXN|RHEA:21236|UM-BBD_reactionID:r0578 go.json anthranilate 2,3-dioxygenase (deaminating)|anthranilate 2,3-hydroxylase (deaminating) activity|anthranilate hydroxylase (deaminating) activity|anthranilate hydroxylase activity|anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating) http://purl.obolibrary.org/obo/GO_0018672 GO:0018671 biolink:MolecularActivity 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O. EC:1.14.13.33|MetaCyc:1.14.13.33-RXN go.json 4-hydroxybenzoate 3-hydroxylase activity|4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))|4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)|4-hydroxybenzoate-3-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018671 GO:0102351 biolink:MolecularActivity gamma-aminobutyrate transaminase (glyoxylate dependent) activity Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine. EC:2.6.1.96|MetaCyc:RXN-13328|RHEA:32267 go.json http://purl.obolibrary.org/obo/GO_0102351 GO:0102350 biolink:MolecularActivity obsolete trans-cerot-2-enoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: hexacosanoyl-CoA(4-) + NADP(3-) = trans-2-hexacosenoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102350 GO:0102353 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102353 GO:0102352 biolink:MolecularActivity phosphatidate kinase activity Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate. MetaCyc:RXN-13336 go.json http://purl.obolibrary.org/obo/GO_0102352 GO:0102355 biolink:MolecularActivity 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H+. EC:3.1.1.91|MetaCyc:RXN-13371|RHEA:33967 go.json http://purl.obolibrary.org/obo/GO_0102355 GO:0102354 biolink:MolecularActivity 11-cis-retinol dehydrogenase activity Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+. MetaCyc:RXN-13363|RHEA:54912 go.json http://purl.obolibrary.org/obo/GO_0102354 GO:0043610 biolink:BiologicalProcess regulation of carbohydrate utilization Any process that modulates the frequency, rate or extent of carbohydrate utilization. go.json regulation of sugar utilization http://purl.obolibrary.org/obo/GO_0043610 GO:0102357 biolink:MolecularActivity mithramycin dehydrogenase activity Catalysis of the reaction: mithramycin + NADP = mithramycin DK + NADPH + H+. MetaCyc:RXN-13385 go.json http://purl.obolibrary.org/obo/GO_0102357 GO:0102356 biolink:MolecularActivity isoitalicene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (+)-isoitalicene. MetaCyc:RXN-13373 go.json http://purl.obolibrary.org/obo/GO_0102356 GO:0102359 biolink:MolecularActivity daphnetin 4-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin = UDP + 4-O- beta -D-glucosyl-daphnetin + H+. EC:2.4.1.126|MetaCyc:RXN-13450 go.json http://purl.obolibrary.org/obo/GO_0102359 GO:0102358 biolink:MolecularActivity daphnetin-8-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin = S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+. MetaCyc:RXN-13448 go.json http://purl.obolibrary.org/obo/GO_0102358 GO:0043616 biolink:BiologicalProcess keratinocyte proliferation The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. go.json http://purl.obolibrary.org/obo/GO_0043616 GO:0043615 biolink:BiologicalProcess astrocyte cell migration The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. go.json astrocyte migration|astrocytic glial cell migration http://purl.obolibrary.org/obo/GO_0043615 GO:0043618 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter in response to stress Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0043618 GO:0043617 biolink:BiologicalProcess cellular response to sucrose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose. go.json http://purl.obolibrary.org/obo/GO_0043617 GO:0043612 biolink:BiologicalProcess isoprene biosynthetic process The chemical reactions and pathways resulting in the formation of isoprene, C5H8. go.json 2-methyl-1,3-butadiene biosynthesis|2-methyl-1,3-butadiene biosynthetic process|hemiterpene biosynthesis|hemiterpene biosynthetic process http://purl.obolibrary.org/obo/GO_0043612 GO:0043611 biolink:BiologicalProcess isoprene metabolic process The chemical reactions and pathways involving isoprene, C5H8. go.json 2-methyl-1,3-butadiene metabolic process|2-methyl-1,3-butadiene metabolism|hemiterpene metabolic process|hemiterpene metabolism|isoprene metabolism http://purl.obolibrary.org/obo/GO_0043611 GO:0043614 biolink:CellularComponent multi-eIF complex A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. go.json multifactor translation initiation factor (eIF) complex http://purl.obolibrary.org/obo/GO_0043614 GO:0043613 biolink:BiologicalProcess isoprene catabolic process The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8. go.json 2-methyl-1,3-butadiene catabolic process|2-methyl-1,3-butadiene catabolism|hemiterpene catabolic process|hemiterpene catabolism http://purl.obolibrary.org/obo/GO_0043613 GO:0043619 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter in response to oxidative stress Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0043619 GO:0102360 biolink:MolecularActivity daphnetin 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin = UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+. EC:2.4.1.91|MetaCyc:RXN-13452 go.json http://purl.obolibrary.org/obo/GO_0102360 GO:0102362 biolink:MolecularActivity esculetin 3-O-glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 3-O-beta-D-glucosyl-esculetin + UDP + H+. MetaCyc:RXN-13472 go.json http://purl.obolibrary.org/obo/GO_0102362 GO:0102361 biolink:MolecularActivity esculetin 4-O-beta-glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 4-O-beta-D-glucosyl-esculetin + UDP + H+. EC:2.4.1.126|MetaCyc:RXN-13471 go.json http://purl.obolibrary.org/obo/GO_0102361 GO:0102363 biolink:MolecularActivity isoscopoletin-O-methyltransferase activity Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-13475 go.json http://purl.obolibrary.org/obo/GO_0102363 GO:0102366 biolink:MolecularActivity 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O. MetaCyc:RXN-13487 go.json http://purl.obolibrary.org/obo/GO_0102366 GO:0102365 biolink:MolecularActivity taxusin 2-alpha-hydroxylase activity Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O. MetaCyc:RXN-13486 go.json http://purl.obolibrary.org/obo/GO_0102365 GO:0102368 biolink:MolecularActivity beta-amyrin 30-monooxygenase activity Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 = 30-hydroxy-beta-amyrin + NADP + H2O. MetaCyc:RXN-13489 go.json http://purl.obolibrary.org/obo/GO_0102368 GO:0043621 biolink:MolecularActivity protein self-association Binding to a domain within the same polypeptide. go.json intramolecular protein binding|protein self association|protein self binding http://purl.obolibrary.org/obo/GO_0043621 goslim_chembl GO:0102367 biolink:MolecularActivity 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7beta-dihydroxytaxusin + NADP + H2O. MetaCyc:RXN-13488 go.json http://purl.obolibrary.org/obo/GO_0102367 GO:0043620 biolink:BiologicalProcess regulation of DNA-templated transcription in response to stress Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json regulation of DNA-dependent transcription in response to stress http://purl.obolibrary.org/obo/GO_0043620 GO:0102369 biolink:MolecularActivity 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ = 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O. MetaCyc:RXN-13491 go.json http://purl.obolibrary.org/obo/GO_0102369 GO:0043627 biolink:BiologicalProcess response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. go.json response to 17alpha-ethynylestradiol|response to estrogen stimulus|response to oestrogen stimulus http://purl.obolibrary.org/obo/GO_0043627 GO:0043626 biolink:CellularComponent PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. go.json PCNA homotrimer|proliferating cell nuclear antigen complex|sliding clamp http://purl.obolibrary.org/obo/GO_0043626 GO:0043629 biolink:BiologicalProcess obsolete ncRNA polyadenylation OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation. go.json non-coding RNA polyadenylation True http://purl.obolibrary.org/obo/GO_0043629 GO:0043628 biolink:BiologicalProcess regulatory ncRNA 3'-end processing Any process involved in forming the mature 3' end of a regulatory non-coding RNA molecule. go.json ncRNA 3' end processing|ncRNA 3'-end processing|small regulatory ncRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0043628 GO:0043623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043623 GO:0043622 biolink:BiologicalProcess cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell. go.json cortical microtubule cytoskeleton organization|cortical microtubule organisation|cortical microtubule organization and biogenesis http://purl.obolibrary.org/obo/GO_0043622 GO:0043625 biolink:CellularComponent delta DNA polymerase complex A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair. go.json delta-DNA polymerase complex http://purl.obolibrary.org/obo/GO_0043625 GO:0043624 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043624 GO:0102371 biolink:MolecularActivity betulin dehydrogenase activity Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 = betulinic aldehyde + NADP(3-) + 2 H2O. MetaCyc:RXN-13498 go.json http://purl.obolibrary.org/obo/GO_0102371 GO:0102370 biolink:MolecularActivity lupeol 28-monooxygenase activity Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ = betulin + NADP(3-) + H2O. MetaCyc:RXN-13497 go.json http://purl.obolibrary.org/obo/GO_0102370 GO:0102373 biolink:MolecularActivity uvaol dehydrogenase activity Catalysis of the reaction: uvaol + NADPH + O2 + H+ = ursolic aldehyde + NADP + 2 H2O. EC:1.14.14.126|MetaCyc:RXN-13501 go.json http://purl.obolibrary.org/obo/GO_0102373 GO:0102372 biolink:MolecularActivity alpha-amyrin 28-monooxygenase activity Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ = uvaol + NADP(3-) + H2O. MetaCyc:RXN-13500 go.json http://purl.obolibrary.org/obo/GO_0102372 GO:0102375 biolink:MolecularActivity 11-oxo-beta-amyrin 30-oxidase activity Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ = glycyrrhetinic acid + 3 NADP + 4 H2O. EC:1.14.14.115|MetaCyc:RXN-13506|RHEA:35499 go.json http://purl.obolibrary.org/obo/GO_0102375 GO:0102374 biolink:MolecularActivity ursolic aldehyde 28-monooxygenase activity Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ = ursolic acid + NADP + H2O. EC:1.14.14.126|MetaCyc:RXN-13502 go.json http://purl.obolibrary.org/obo/GO_0102374 GO:0043630 biolink:BiologicalProcess obsolete ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process OBSOLETE. The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism. go.json ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process|ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process True http://purl.obolibrary.org/obo/GO_0043630 GO:0102377 biolink:MolecularActivity steviol 13-O glucosyltransferase activity Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+. MetaCyc:RXN-13511 go.json http://purl.obolibrary.org/obo/GO_0102377 GO:0102376 biolink:MolecularActivity lupeol 28-oxidase activity Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ = betulinic acid + 3 NADP + 4 H2O. MetaCyc:RXN-13507 go.json http://purl.obolibrary.org/obo/GO_0102376 GO:0102379 biolink:MolecularActivity steviolbioside glucosyltransferase activity (stevioside forming) Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+. MetaCyc:RXN-13514 go.json http://purl.obolibrary.org/obo/GO_0102379 GO:0043632 biolink:BiologicalProcess modification-dependent macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule. go.json http://purl.obolibrary.org/obo/GO_0043632 GO:0043631 biolink:BiologicalProcess obsolete RNA polyadenylation OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0043631 GO:0102378 biolink:MolecularActivity steviolmonoside glucosyltransferase activity Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+. MetaCyc:RXN-13512 go.json http://purl.obolibrary.org/obo/GO_0102378 GO:0043638 biolink:BiologicalProcess puromycin biosynthetic process The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. go.json http://purl.obolibrary.org/obo/GO_0043638 GO:0043637 biolink:BiologicalProcess puromycin metabolic process The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. go.json puromycin metabolism http://purl.obolibrary.org/obo/GO_0043637 GO:0043639 biolink:BiologicalProcess benzoate catabolic process The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. go.json benzoate breakdown|benzoate catabolism|benzoate degradation http://purl.obolibrary.org/obo/GO_0043639 GO:0043634 biolink:BiologicalProcess polyadenylation-dependent ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA. go.json poly(A)-dependent ncRNA catabolic process http://purl.obolibrary.org/obo/GO_0043634 GO:0043633 biolink:BiologicalProcess polyadenylation-dependent RNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA. go.json http://purl.obolibrary.org/obo/GO_0043633 GO:0043636 biolink:BiologicalProcess bisphenol A catabolic process The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins. go.json bisphenol-A catabolic process|bisphenol-A catabolism http://purl.obolibrary.org/obo/GO_0043636 GO:0043635 biolink:BiologicalProcess methylnaphthalene catabolic process The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar. go.json 1-MN catabolic process|1-MN catabolism|1-methylnaphthalene catabolic process|1-methylnaphthalene catabolism|2-MN catabolic process|2-MN catabolism|2-methylnaphthalene catabolic process|2-methylnaphthalene catabolism http://purl.obolibrary.org/obo/GO_0043635 GO:0102380 biolink:MolecularActivity steviolbioside glucosyltransferase activity (rebaudioside B forming) Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+. MetaCyc:RXN-13516 go.json http://purl.obolibrary.org/obo/GO_0102380 GO:0102382 biolink:MolecularActivity rebaudioside B glucosyltransferase activity Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP + H+. MetaCyc:RXN-13518 go.json http://purl.obolibrary.org/obo/GO_0102382 GO:0102381 biolink:MolecularActivity stevioside glucosyltransferase activity (rebaudioside A forming) Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+. MetaCyc:RXN-13517 go.json http://purl.obolibrary.org/obo/GO_0102381 GO:0102384 biolink:MolecularActivity 19-O-beta-glucopyranosyl-steviol glucosyltransferase activity Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose = rubusoside + UDP + H+. MetaCyc:RXN-13521 go.json http://purl.obolibrary.org/obo/GO_0102384 GO:0102383 biolink:MolecularActivity steviol 19-O glucosyltransferase activity Catalysis of the reaction: steviol + UDP-alpha-D-glucose = 19-O-beta-glucopyranosyl-steviol + UDP + H+. MetaCyc:RXN-13520 go.json http://purl.obolibrary.org/obo/GO_0102383 GO:0102386 biolink:MolecularActivity phenylacetaldehyde reductase activity Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+. MetaCyc:RXN-13536 go.json http://purl.obolibrary.org/obo/GO_0102386 GO:0102385 biolink:MolecularActivity patchoulol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = seychellene + diphosphoric acid. MetaCyc:RXN-13522 go.json http://purl.obolibrary.org/obo/GO_0102385 GO:0102388 biolink:MolecularActivity UDP-N,N'-diacetylbacillosamine 2-epimerase activity Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+. EC:3.2.1.184|MetaCyc:RXN-13574|RHEA:34491 go.json http://purl.obolibrary.org/obo/GO_0102388 GO:0043641 biolink:BiologicalProcess novobiocin metabolic process The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. Wikipedia:Novobiocin go.json novobiocin metabolism http://purl.obolibrary.org/obo/GO_0043641 GO:0102387 biolink:MolecularActivity 2-phenylethanol acetyltransferase activity Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A. EC:2.3.1.224|MetaCyc:RXN-13542 go.json http://purl.obolibrary.org/obo/GO_0102387 GO:0043640 biolink:BiologicalProcess benzoate catabolic process via hydroxylation The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol. MetaCyc:PWY-2503 go.json benzoate breakdown via hydroxylation|benzoate degradation via hydroxylation http://purl.obolibrary.org/obo/GO_0043640 GO:0043643 biolink:BiologicalProcess tetracycline metabolic process The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). go.json tetracyclin metabolic process|tetracyclin metabolism|tetracycline metabolism http://purl.obolibrary.org/obo/GO_0043643 GO:0043642 biolink:BiologicalProcess novobiocin biosynthetic process The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. Wikipedia:Novobiocin go.json http://purl.obolibrary.org/obo/GO_0043642 GO:0102389 biolink:MolecularActivity polyprenol reductase activity Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol. EC:1.3.1.94|MetaCyc:RXN-9971|RHEA:34279 go.json http://purl.obolibrary.org/obo/GO_0102389 GO:0043649 biolink:BiologicalProcess dicarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. go.json dicarboxylate catabolic process|dicarboxylate catabolism|dicarboxylic acid breakdown|dicarboxylic acid catabolism|dicarboxylic acid degradation http://purl.obolibrary.org/obo/GO_0043649 GO:0043648 biolink:BiologicalProcess dicarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). go.json dicarboxylate metabolic process|dicarboxylate metabolism|dicarboxylic acid metabolism http://purl.obolibrary.org/obo/GO_0043648 GO:0043645 biolink:BiologicalProcess cephalosporin metabolic process The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria. go.json cephalosporin metabolism http://purl.obolibrary.org/obo/GO_0043645 GO:0043644 biolink:BiologicalProcess tetracycline biosynthetic process The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). go.json tetracyclin biosynthesis|tetracyclin biosynthetic process http://purl.obolibrary.org/obo/GO_0043644 GO:0043647 biolink:BiologicalProcess inositol phosphate metabolic process The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. go.json inositol phosphate metabolism|myo-inositol phosphate metabolic process|myo-inositol phosphate metabolism http://purl.obolibrary.org/obo/GO_0043647 GO:0043646 biolink:BiologicalProcess cephalosporin biosynthetic process The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria. go.json http://purl.obolibrary.org/obo/GO_0043646 GO:0102311 biolink:MolecularActivity 8-hydroxygeraniol dehydrogenase activity Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP = (6E)-8-oxogeranial + 2 NADPH + 2 H+. EC:1.1.1.324|MetaCyc:RXN-12961|RHEA:32659 go.json http://purl.obolibrary.org/obo/GO_0102311 GO:0043652 biolink:BiologicalProcess engulfment of apoptotic cell The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte. go.json engulfment of apoptotic cell corpse|engulfment of cell corpse http://purl.obolibrary.org/obo/GO_0043652 GO:0043651 biolink:BiologicalProcess linoleic acid metabolic process The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. Wikipedia:Linoleic_acid go.json linoleic acid metabolism http://purl.obolibrary.org/obo/GO_0043651 GO:0102310 biolink:MolecularActivity dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) = dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H. MetaCyc:RXN-12940 go.json http://purl.obolibrary.org/obo/GO_0102310 GO:0043654 biolink:BiologicalProcess recognition of apoptotic cell The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis. go.json detection of apoptotic cell|detection of apoptotic cell corpse|detection of cell corpse|recognition of apoptotic cell corpse|recognition of cell corpse http://purl.obolibrary.org/obo/GO_0043654 GO:0102313 biolink:MolecularActivity 1,8-cineole synthase activity Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid. EC:4.2.3.108|MetaCyc:RXN-12980|RHEA:32543 go.json http://purl.obolibrary.org/obo/GO_0102313 GO:0102312 biolink:MolecularActivity 4-coumaroyl 2'-hydroxylase activity Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide. EC:1.14.11.62|MetaCyc:RXN-12963|RHEA:57868 go.json http://purl.obolibrary.org/obo/GO_0102312 GO:0043653 biolink:BiologicalProcess mitochondrial fragmentation involved in apoptotic process The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. go.json mitochondrial fission during apoptosis|mitochondrial fragmentation involved in apoptosis http://purl.obolibrary.org/obo/GO_0043653 GO:0102315 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102315 GO:0102317 biolink:MolecularActivity 4-methylaminobutyrate oxidase (demethylating) activity Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O = gamma-aminobutyric acid + formaldehyde + hydrogen peroxide. EC:1.5.3.19|MetaCyc:RXN-13067|RHEA:33907 go.json http://purl.obolibrary.org/obo/GO_0102317 GO:0043650 biolink:BiologicalProcess dicarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. go.json dicarboxylate biosynthesis|dicarboxylate biosynthetic process|dicarboxylic acid anabolism|dicarboxylic acid biosynthesis|dicarboxylic acid formation|dicarboxylic acid synthesis http://purl.obolibrary.org/obo/GO_0043650 GO:0102316 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102316 GO:0102319 biolink:MolecularActivity 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine = H+ + 2'-N-acetylparomamine(2+) + UDP(3-). EC:2.4.1.283|MetaCyc:RXN-13122|RHEA:33947 go.json http://purl.obolibrary.org/obo/GO_0102319 GO:0102318 biolink:MolecularActivity 2-deoxystreptamine glucosyltransferase activity Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+. EC:2.4.1.284|MetaCyc:RXN-13121|RHEA:34063 go.json http://purl.obolibrary.org/obo/GO_0102318 GO:0043659 biolink:CellularComponent symbiosome A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane). go.json http://purl.obolibrary.org/obo/GO_0043659 GO:0043656 biolink:CellularComponent host intracellular region That space within the plasma membrane of a host cell. go.json host intracellular|intracellular region of host http://purl.obolibrary.org/obo/GO_0043656 GO:0043655 biolink:CellularComponent host extracellular space The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream. go.json extracellular space of host http://purl.obolibrary.org/obo/GO_0043655 GO:0043658 biolink:CellularComponent host symbiosome A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell. go.json http://purl.obolibrary.org/obo/GO_0043658 GO:0043657 biolink:CellularComponent host cell A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. go.json http://purl.obolibrary.org/obo/GO_0043657 GO:0102320 biolink:MolecularActivity 1,8-cineole 2-exo-monooxygenase activity Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 = 2-exo-hydroxy-1,8-cineole + NADP + H2O. EC:1.14.14.56|MetaCyc:RXN-4342|RHEA:32895 go.json http://purl.obolibrary.org/obo/GO_0102320 GO:0043663 biolink:CellularComponent host bacteroid-containing symbiosome A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell. go.json http://purl.obolibrary.org/obo/GO_0043663 GO:0102322 biolink:MolecularActivity 2-propylphenol monooxygenase activity Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD. MetaCyc:RXN-13151|RHEA:63524 go.json http://purl.obolibrary.org/obo/GO_0102322 GO:0102321 biolink:MolecularActivity 2,2'-hydroxybiphenyl monooxygenase activity Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ = biphenyl-2,2',3-triol + H2O + NAD. EC:1.14.13.44|MetaCyc:MONOMER-17239|RHEA:63512 go.json http://purl.obolibrary.org/obo/GO_0102321 GO:0043662 biolink:CellularComponent peribacteroid fluid The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome. go.json http://purl.obolibrary.org/obo/GO_0043662 GO:0043665 biolink:CellularComponent host peribacteroid fluid The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell. go.json http://purl.obolibrary.org/obo/GO_0043665 GO:0102324 biolink:MolecularActivity 2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+. MetaCyc:RXN-13157 go.json http://purl.obolibrary.org/obo/GO_0102324 GO:0043664 biolink:CellularComponent host peribacteroid membrane A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). go.json http://purl.obolibrary.org/obo/GO_0043664 GO:0102323 biolink:MolecularActivity 2-isopropylphenol monooxygenase activity Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD. MetaCyc:RXN-13152|RHEA:63520 go.json http://purl.obolibrary.org/obo/GO_0102323 GO:0102326 biolink:MolecularActivity 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O = 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+. MetaCyc:RXN-13171 go.json http://purl.obolibrary.org/obo/GO_0102326 GO:0102325 biolink:MolecularActivity 2,2',3-trihydroxybiphenyl monooxygenase activity Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ = 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O. MetaCyc:RXN-13169|RHEA:63516 go.json http://purl.obolibrary.org/obo/GO_0102325 GO:0043661 biolink:CellularComponent peribacteroid membrane A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). go.json http://purl.obolibrary.org/obo/GO_0043661 GO:0102328 biolink:MolecularActivity 3-oxoacid decarboxylase activity Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone. MetaCyc:RXN-13248 go.json http://purl.obolibrary.org/obo/GO_0102328 GO:0043660 biolink:CellularComponent bacteroid-containing symbiosome A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants. go.json http://purl.obolibrary.org/obo/GO_0043660 GO:0102327 biolink:MolecularActivity 3-oxoacyl-CoA hydrolase activity Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid. MetaCyc:RXN-13247 go.json http://purl.obolibrary.org/obo/GO_0102327 GO:0102329 biolink:MolecularActivity obsolete hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: 16-hydroxy-hentriaconta-3,6,9,12,19,22,25,28-octaene-15-oyl-CoA + NADP = hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA + NADPH + H+. MetaCyc:RXN-13251 go.json True http://purl.obolibrary.org/obo/GO_0102329 GO:0043667 biolink:CellularComponent pollen wall The wall surrounding a mature pollen grain; a multilayered structure consisting of a pectocellulosic intine surrounded by a sporopollenin-based exine, which itself contains two layers, the inner nexine and the outer sexine. go.json microspore wall http://purl.obolibrary.org/obo/GO_0043667 GO:0043666 biolink:BiologicalProcess regulation of phosphoprotein phosphatase activity Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. go.json regulation of calcineurin activity|regulation of protein phosphatase 3 activity|regulation of protein phosphatase type 2 activity|regulation of protein phosphatase type 2A activity|regulation of protein phosphatase type 2B activity http://purl.obolibrary.org/obo/GO_0043666 gocheck_do_not_annotate GO:0043669 biolink:CellularComponent ectexine The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections. go.json http://purl.obolibrary.org/obo/GO_0043669 GO:0043668 biolink:CellularComponent exine The outer layer of the pollen grain wall which is composed primarily of sporopollenin. go.json http://purl.obolibrary.org/obo/GO_0043668 GO:0102331 biolink:MolecularActivity heptadecanoyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. MetaCyc:RXN-13259 go.json http://purl.obolibrary.org/obo/GO_0102331 GO:0102330 biolink:MolecularActivity palmitoyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. MetaCyc:RXN-13258 go.json http://purl.obolibrary.org/obo/GO_0102330 GO:0043674 biolink:CellularComponent columella A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella). go.json sexine 1 http://purl.obolibrary.org/obo/GO_0043674 GO:0102333 biolink:MolecularActivity stearoyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. MetaCyc:RXN-13261 go.json http://purl.obolibrary.org/obo/GO_0102333 GO:0102332 biolink:MolecularActivity fatty-acyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor. MetaCyc:RXN-13260 go.json http://purl.obolibrary.org/obo/GO_0102332 GO:0043673 biolink:CellularComponent sexine The outer, sculptured layer of the exine, which lies above the nexine. go.json http://purl.obolibrary.org/obo/GO_0043673 GO:0043676 biolink:CellularComponent tectum The layer of sexine which forms a roof over the columella, granules or other infratectal elements. go.json sexine 2 http://purl.obolibrary.org/obo/GO_0043676 GO:0102335 biolink:MolecularActivity N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine = N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+. EC:2.4.1.290|MetaCyc:RXN-13274|RHEA:34511 go.json http://purl.obolibrary.org/obo/GO_0102335 GO:0102334 biolink:MolecularActivity N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP. EC:2.7.8.36|MetaCyc:RXN-13269|RHEA:34515 go.json http://purl.obolibrary.org/obo/GO_0102334 GO:0043675 biolink:CellularComponent sculpture element The third layer of the sexine. go.json http://purl.obolibrary.org/obo/GO_0043675 GO:0102337 biolink:MolecularActivity obsolete 3-oxo-cerotoyl-CoA synthase activity OBSOLETE. Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ = 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A. go.json True http://purl.obolibrary.org/obo/GO_0102337 GO:0043670 biolink:CellularComponent foot layer The inner layer of the ectexine. go.json nexine 1 http://purl.obolibrary.org/obo/GO_0043670 GO:0102336 biolink:MolecularActivity obsolete 3-oxo-arachidoyl-CoA synthase activity OBSOLETE. Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ = 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A. go.json True http://purl.obolibrary.org/obo/GO_0102336 GO:0043672 biolink:CellularComponent nexine The inner, non-sculptured part of the exine which lies below the sexine. go.json http://purl.obolibrary.org/obo/GO_0043672 GO:0102339 biolink:MolecularActivity obsolete 3-oxo-arachidoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) = 3-oxoicosanoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102339 GO:0102338 biolink:MolecularActivity obsolete 3-oxo-lignoceronyl-CoA synthase activity OBSOLETE. Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ = 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A. go.json True http://purl.obolibrary.org/obo/GO_0102338 GO:0043671 biolink:CellularComponent endexine The inner part of the exine, which stains. go.json http://purl.obolibrary.org/obo/GO_0043671 GO:0043678 biolink:CellularComponent intine The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0043678 GO:0043677 biolink:CellularComponent obsolete germination pore OBSOLETE. A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location. Wikipedia:Germ_pore go.json germ pore True http://purl.obolibrary.org/obo/GO_0043677 GO:0043679 biolink:CellularComponent axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. NIF_Subcellular:nlx_subcell_20090512 go.json axon terminal|axon terminal specialization|nerve ending http://purl.obolibrary.org/obo/GO_0043679 GO:0102340 biolink:MolecularActivity obsolete 3-oxo-behenoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) = 3-oxodocosanoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102340 GO:0102342 biolink:MolecularActivity obsolete 3-oxo-cerotoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP = 3-oxohexacosanoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102342 GO:0102341 biolink:MolecularActivity obsolete 3-oxo-lignoceroyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP = 3-oxotetracosanoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102341 GO:0102344 biolink:MolecularActivity obsolete 3-hydroxy-behenoyl-CoA dehydratase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA = trans-2-docosenoyl-CoA + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102344 GO:0043685 biolink:BiologicalProcess conversion of glutamyl-tRNA to glutaminyl-tRNA The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA. go.json http://purl.obolibrary.org/obo/GO_0043685 GO:0043684 biolink:CellularComponent type IV secretion system complex A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s). go.json T4SS complex|type IV protein secretion system complex http://purl.obolibrary.org/obo/GO_0043684 GO:0102343 biolink:MolecularActivity obsolete 3-hydroxy-arachidoyl-CoA dehydratase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA = trans-2-icosenoyl-CoA + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102343 GO:0102346 biolink:MolecularActivity obsolete 3-hydroxy-cerotoyl-CoA dehydratase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) = trans-2-hexacosenoyl-CoA(4-) + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102346 GO:0043687 biolink:BiologicalProcess post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. Wikipedia:Posttranslational_modification go.json PTM|post-translational amino acid modification|post-translational modification|posttranslational amino acid modification|posttranslational modification|posttranslational protein modification http://purl.obolibrary.org/obo/GO_0043687 GO:0102345 biolink:MolecularActivity obsolete 3-hydroxy-lignoceroyl-CoA dehydratase activity OBSOLETE. Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA(4-) = trans-2-tetracosenoyl-CoA + H2O. go.json True http://purl.obolibrary.org/obo/GO_0102345 GO:0043686 biolink:BiologicalProcess co-translational protein modification The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome. go.json co-translational amino acid modification|co-translational modification|cotranslational amino acid modification|cotranslational modification|cotranslational protein modification http://purl.obolibrary.org/obo/GO_0043686 GO:0043681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043681 GO:0102348 biolink:MolecularActivity obsolete trans-docosan-2-enoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: behenoyl-CoA + NADP = trans-2-docosenoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102348 GO:0102347 biolink:MolecularActivity obsolete trans-arachidon-2-enoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: icosanoyl-CoA(4-) + NADP(3-) = trans-2-icosenoyl-CoA(4-) + NADPH(4-) + H+. go.json True http://purl.obolibrary.org/obo/GO_0102347 GO:0043680 biolink:CellularComponent filiform apparatus A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells. go.json http://purl.obolibrary.org/obo/GO_0043680 GO:0043683 biolink:BiologicalProcess type IV pilus assembly The assembly from its constituent parts of a type IV pilus. go.json type IV fimbria assembly|type IV fimbria biogenesis|type IV fimbriae assembly|type IV fimbriae biogenesis|type IV fimbrial assembly|type IV fimbrial biogenesis|type IV fimbrium assembly|type IV fimbrium biogenesis|type IV pilus biogenesis http://purl.obolibrary.org/obo/GO_0043683 GO:0043682 biolink:MolecularActivity P-type divalent copper transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). EC:7.2.2.9|MetaCyc:TRANS-RXN-178|RHEA:10376|Reactome:R-HSA-3697838|Reactome:R-HSA-6803545|Reactome:R-HSA-936802|Reactome:R-HSA-936895 go.json Cu(2+)-exporting ATPase activity|Cu2+-exporting ATPase activity|copper exporting ATPase activity|copper transmembrane transporter activity, phosphorylative mechanism|copper-exporting ATPase activity|copper-translocating P-type ATPase activity|copper-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0043682 GO:0102349 biolink:MolecularActivity obsolete trans-lignocero-2-enoyl-CoA reductase activity OBSOLETE. Catalysis of the reaction: tetracosanoyl-CoA + NADP = trans-2-tetracosenoyl-CoA + NADPH + H+. go.json True http://purl.obolibrary.org/obo/GO_0102349 GO:0043689 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043689 GO:0043688 biolink:BiologicalProcess conversion of aspartyl-tRNA to asparaginyl-tRNA The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA. go.json http://purl.obolibrary.org/obo/GO_0043688 GO:0102391 biolink:MolecularActivity decanoate-CoA ligase activity Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA. MetaCyc:RXN-13614|RHEA:33627 go.json http://purl.obolibrary.org/obo/GO_0102391 GO:0102390 biolink:MolecularActivity mycophenolic acid acyl-glucuronide esterase activity Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O = mycophenolate + H+ + D-glucopyranuronate. EC:3.1.1.93|MetaCyc:RXN-13605|RHEA:34179 go.json http://purl.obolibrary.org/obo/GO_0102390 GO:0102393 biolink:MolecularActivity decanoyl-[acp] 2-dehydrogenase activity Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein = FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF. MetaCyc:RXN-13624 go.json http://purl.obolibrary.org/obo/GO_0102393 GO:0102392 biolink:MolecularActivity decanoate-[HmqF protein] ligase activity Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein = AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein. MetaCyc:RXN-13623 go.json http://purl.obolibrary.org/obo/GO_0102392 GO:0102395 biolink:MolecularActivity 9-cis-beta-carotene 9',10'-cleavage oxygenase activity Catalysis of the reaction: 9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone. EC:1.13.11.68|MetaCyc:RXN-13642|RHEA:34399 go.json http://purl.obolibrary.org/obo/GO_0102395 GO:0102394 biolink:MolecularActivity 4-hydroxy-L-isoleucine dehydrogenase activity Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD = (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+. MetaCyc:RXN-13637 go.json http://purl.obolibrary.org/obo/GO_0102394 GO:0102396 biolink:MolecularActivity 9-cis-10'-apo-beta-carotenal cleavage oxygenase activity Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal. EC:1.13.11.69|MetaCyc:RXN-13643|RHEA:34403 go.json http://purl.obolibrary.org/obo/GO_0102396 GO:0102399 biolink:MolecularActivity dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+. MetaCyc:RXN-13658 go.json http://purl.obolibrary.org/obo/GO_0102399 GO:0102398 biolink:MolecularActivity dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+. MetaCyc:RXN-13657 go.json http://purl.obolibrary.org/obo/GO_0102398 GO:0043605 biolink:BiologicalProcess amide catabolic process The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. go.json cellular amide catabolic process http://purl.obolibrary.org/obo/GO_0043605 GO:0043604 biolink:BiologicalProcess amide biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. go.json http://purl.obolibrary.org/obo/GO_0043604 GO:0043607 biolink:BiologicalProcess formamide biosynthetic process The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid. go.json http://purl.obolibrary.org/obo/GO_0043607 GO:0043606 biolink:BiologicalProcess formamide metabolic process The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid. go.json formamide metabolism http://purl.obolibrary.org/obo/GO_0043606 GO:0043601 biolink:CellularComponent nuclear replisome A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. go.json http://purl.obolibrary.org/obo/GO_0043601 GO:0043600 biolink:CellularComponent cytoplasmic replisome A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins. go.json prokaryotic replisome http://purl.obolibrary.org/obo/GO_0043600 GO:0043603 biolink:BiologicalProcess amide metabolic process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. go.json amide metabolism|cellular amide metabolic process http://purl.obolibrary.org/obo/GO_0043603 goslim_pir GO:0043602 biolink:BiologicalProcess nitrate catabolic process The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid. go.json nitrate disassimilation|nitrate dissimilation http://purl.obolibrary.org/obo/GO_0043602 GO:0043609 biolink:BiologicalProcess regulation of carbon utilization Any process that modulates the frequency, rate, or extent of carbon utilization. go.json http://purl.obolibrary.org/obo/GO_0043609 GO:0043608 biolink:BiologicalProcess formamide catabolic process The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid. go.json http://purl.obolibrary.org/obo/GO_0043608 GO:0004008 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004008 GO:0004007 biolink:MolecularActivity obsolete heavy metal-exporting ATPase activity OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate. go.json heavy metal-exporting ATPase activity True http://purl.obolibrary.org/obo/GO_0004007 GO:0004009 biolink:MolecularActivity obsolete ATP-binding cassette (ABC) transporter activity OBSOLETE. (Was not defined before being made obsolete). go.json ATP-binding cassette (ABC) transporter activity True http://purl.obolibrary.org/obo/GO_0004009 GO:0004004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004004 GO:0004003 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004003 GO:0004006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004006 GO:0004005 biolink:MolecularActivity obsolete plasma membrane cation-transporting ATPase OBSOLETE. (Was not defined before being made obsolete). go.json plasma membrane cation-transporting ATPase True http://purl.obolibrary.org/obo/GO_0004005 GO:0004000 biolink:MolecularActivity adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3. EC:3.5.4.4|MetaCyc:ADENODEAMIN-RXN|RHEA:24408|Reactome:R-HSA-5693346 go.json adenosine aminohydrolase activity|adenosine deaminase reaction http://purl.obolibrary.org/obo/GO_0004000 GO:0004002 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004002 GO:0004001 biolink:MolecularActivity adenosine kinase activity Catalysis of the reaction: ATP + adenosine = ADP + AMP. EC:2.7.1.20|MetaCyc:ADENOSINE-KINASE-RXN|RHEA:20824|Reactome:R-HSA-109624|Reactome:R-HSA-9754974 go.json ATP:adenosine 5'-phosphotransferase activity|adenosine 5-phosphotransferase activity|adenosine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004001 GO:0018649 biolink:MolecularActivity tetrahydrofuran hydroxylase activity Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran. EC:1.14.13.-|UM-BBD_reactionID:r0017 go.json http://purl.obolibrary.org/obo/GO_0018649 GO:0018648 biolink:MolecularActivity methanesulfonate monooxygenase activity Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O. EC:1.14.13.111|MetaCyc:RXN-9770|RHEA:26077 go.json MSA monooxygenase activity|MSAMO activity|mesylate monooxygenase activity|methanesulfonate,FMNH2:oxygen oxidoreductase activity|methanesulfonate,NADH:oxygen oxidoreductase activity|methanesulfonic acid monooxygenase activity|methanesulphonic acid monooxygenase activity http://purl.obolibrary.org/obo/GO_0018648 GO:0018645 biolink:MolecularActivity alkene monooxygenase activity Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O. EC:1.14.13.69|MetaCyc:1.14.13.69-RXN|RHEA:11792|UM-BBD_enzymeID:e0039 go.json alkene epoxygenase activity|alkene,NADH:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018645 GO:0018644 biolink:MolecularActivity toluene 2-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene. EC:1.14.13.243|MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN|RHEA:20349|UM-BBD_enzymeID:e0222 go.json http://purl.obolibrary.org/obo/GO_0018644 GO:0018647 biolink:MolecularActivity phenanthrene 1,2-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide. EC:1.14.13.-|UM-BBD_enzymeID:e0333 go.json http://purl.obolibrary.org/obo/GO_0018647 GO:0018646 biolink:MolecularActivity 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate. EC:1.14.13.-|UM-BBD_reactionID:r0736 go.json http://purl.obolibrary.org/obo/GO_0018646 GO:0018641 biolink:MolecularActivity 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. EC:1.14.13.-|UM-BBD_reactionID:r0048 go.json http://purl.obolibrary.org/obo/GO_0018641 GO:0018640 biolink:MolecularActivity dibenzothiophene monooxygenase activity Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O. MetaCyc:RXN-621|RHEA:49076|UM-BBD_enzymeID:e0214 go.json http://purl.obolibrary.org/obo/GO_0018640 GO:0018643 biolink:MolecularActivity carbon disulfide oxygenase activity Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide. EC:1.14.13.-|UM-BBD_reactionID:r0599 go.json carbon disulphide oxygenase activity http://purl.obolibrary.org/obo/GO_0018643 GO:0018642 biolink:MolecularActivity chlorophenol 4-monooxygenase activity Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol. EC:1.14.13.-|UM-BBD_enzymeID:e0252 go.json http://purl.obolibrary.org/obo/GO_0018642 GO:0004019 biolink:MolecularActivity adenylosuccinate synthase activity Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate. EC:6.3.4.4|KEGG_REACTION:R01135|MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN|RHEA:15753|Reactome:R-HSA-111524 go.json IMP--aspartate ligase activity|IMP:L-aspartate ligase (GDP-forming)|adenylosuccinate synthetase activity|succino-AMP synthetase activity|succinoadenylic kinosynthetase activity http://purl.obolibrary.org/obo/GO_0004019 GO:0004018 biolink:MolecularActivity N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. EC:4.3.2.2|KEGG_REACTION:R01083|MetaCyc:AMPSYN-RXN|RHEA:16853 go.json 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity|adenylosuccinase activity|adenylosuccinate lyase activity|succino AMP-lyase activity http://purl.obolibrary.org/obo/GO_0004018 GO:0004015 biolink:MolecularActivity adenosylmethionine-8-amino-7-oxononanoate transaminase activity Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate. EC:2.6.1.62|KEGG_REACTION:R03231|MetaCyc:DAPASYN-RXN|RHEA:16861 go.json 7,8-diamino-pelargonic acid aminotransferase activity|7,8-diaminonanoate transaminase activity|7,8-diaminononanoate aminotransferase activity|7,8-diaminononanoate transaminase activity|7,8-diaminopelargonic acid aminotransferase activity|7-keto-8-aminopelargonic acid|7-keto-8-aminopelargonic acid aminotransferase activity|DAPA aminotransferase activity|DAPA transaminase activity|S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity|adenosyl methionine-8-amino-7-oxononanoate transaminase activity|adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity|adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity|diaminopelargonate synthase activity http://purl.obolibrary.org/obo/GO_0004015 GO:0004014 biolink:MolecularActivity adenosylmethionine decarboxylase activity Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. EC:4.1.1.50|KEGG_REACTION:R00178|MetaCyc:SAMDECARB-RXN|RHEA:15981|Reactome:R-HSA-351222 go.json S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]|S-adenosyl-L-methionine carboxy-lyase activity|S-adenosyl-L-methionine decarboxylase activity|S-adenosylmethionine decarboxylase activity|adenosyl methionine decarboxylase activity http://purl.obolibrary.org/obo/GO_0004014 GO:0004017 biolink:MolecularActivity adenylate kinase activity Catalysis of the reaction: ATP + AMP = 2 ADP. EC:2.7.4.3|MetaCyc:ADENYL-KIN-RXN|RHEA:12973|Reactome:R-HSA-110141|Reactome:R-HSA-110144|Reactome:R-HSA-110145|Reactome:R-HSA-74220 go.json 5'-AMP-kinase activity|ATP:AMP phosphotransferase activity|adenylic kinase activity|adenylokinase activity|myokinase activity http://purl.obolibrary.org/obo/GO_0004017 GO:0004016 biolink:MolecularActivity adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. EC:4.6.1.1|MetaCyc:ADENYLATECYC-RXN|RHEA:15389|Reactome:R-HSA-164377|Reactome:R-HSA-170676|Reactome:R-HSA-381607|Reactome:R-HSA-392129|Reactome:R-HSA-5211224|Reactome:R-HSA-5610727|Reactome:R-HSA-9712183 go.json 3',5'-cyclic AMP synthetase activity|ATP diphosphate-lyase (cyclizing) activity|ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity|ATP pyrophosphate-lyase activity|adenyl cyclase activity|adenylyl cyclase activity|adenylylcyclase activity|cAMP generating peptide activity http://purl.obolibrary.org/obo/GO_0004016 GO:0004011 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004011 GO:0004010 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004010 GO:0004013 biolink:MolecularActivity adenosylhomocysteinase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. EC:3.13.2.1|MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN|RHEA:21708|Reactome:R-HSA-174401|Reactome:R-HSA-5579084 go.json AdoHcyase activity|S-adenosyl-L-homocysteine hydrolase activity|S-adenosylhomocysteinase activity|S-adenosylhomocysteine hydrolase activity|S-adenosylhomocysteine synthase activity|SAHase activity|adenosylhomocysteine hydrolase activity http://purl.obolibrary.org/obo/GO_0004013 goslim_chembl GO:0004012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004012 GO:0018659 biolink:MolecularActivity 4-hydroxybenzoate 3-monooxygenase activity Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. EC:1.14.13.2|MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0109 go.json 4-hydroxybenzoate 3-hydroxylase activity|4-hydroxybenzoate monooxygenase activity|4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)|p-hydroxybenzoate hydrolyase activity|p-hydroxybenzoate hydroxylase activity|p-hydroxybenzoate-3-hydroxylase activity|p-hydroxybenzoic acid hydrolase activity|p-hydroxybenzoic acid hydroxylase activity|p-hydroxybenzoic hydroxylase activity|para-hydroxybenzoate hydroxylase activity http://purl.obolibrary.org/obo/GO_0018659 GO:0018656 biolink:MolecularActivity phenanthrene 3,4-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide. EC:1.14.13.-|UM-BBD_reactionID:r0508 go.json http://purl.obolibrary.org/obo/GO_0018656 GO:0018655 biolink:MolecularActivity 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA. EC:1.14.13.-|UM-BBD_reactionID:r0430 go.json http://purl.obolibrary.org/obo/GO_0018655 GO:0018658 biolink:MolecularActivity salicylate 1-monooxygenase activity Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2. EC:1.14.13.1|MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN|RHEA:11004|UM-BBD_enzymeID:e0149 go.json salicylate 1-hydroxylase activity|salicylate hydroxylase (decarboxylating)|salicylate hydroxylase activity|salicylate monooxygenase activity|salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)|salicylic hydroxylase activity http://purl.obolibrary.org/obo/GO_0018658 GO:0018657 biolink:MolecularActivity toluene 3-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene. EC:1.14.13.-|MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN|UM-BBD_enzymeID:e0224 go.json http://purl.obolibrary.org/obo/GO_0018657 GO:0018652 biolink:MolecularActivity toluene-sulfonate methyl-monooxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol. MetaCyc:TSMOS-RXN|RHEA:51024|UM-BBD_reactionID:r0290 go.json toluene-sulphonate methyl-monooxygenase activity http://purl.obolibrary.org/obo/GO_0018652 GO:0018651 biolink:MolecularActivity toluene-4-sulfonate monooxygenase activity Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene. EC:1.14.13.-|UM-BBD_reactionID:r0296 go.json toluene-4-sulphonate monooxygenase activity http://purl.obolibrary.org/obo/GO_0018651 GO:0018654 biolink:MolecularActivity 2-hydroxy-phenylacetate hydroxylase activity Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate. EC:1.14.13.-|UM-BBD_reactionID:r0252 go.json http://purl.obolibrary.org/obo/GO_0018654 GO:0018653 biolink:MolecularActivity 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. EC:1.14.13.-|UM-BBD_reactionID:r0046 go.json http://purl.obolibrary.org/obo/GO_0018653 GO:0018650 biolink:MolecularActivity styrene monooxygenase activity Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide. EC:1.14.13.-|UM-BBD_reactionID:r0225 go.json http://purl.obolibrary.org/obo/GO_0018650 GO:0018627 biolink:MolecularActivity 2-aminobenzenesulfonate 2,3-dioxygenase activity Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol. EC:1.14.12.14|KEGG_REACTION:R05156|MetaCyc:2ASDOSALCAL-RXN|RHEA:23468|UM-BBD_reactionID:r0218 go.json 2-aminobenzenesulfonate dioxygenase activity|2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)|2-aminobenzenesulphonate 2,3-dioxygenase activity|2-aminobenzenesulphonate dioxygenase activity|2-aminosulfobenzene 2,3-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018627 GO:0018626 biolink:MolecularActivity 2-chlorobenzoate 1,2-dioxygenase activity Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2. EC:1.14.12.13|MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN|RHEA:21652|UM-BBD_reactionID:r0632 go.json 2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)|2-halobenzoate 1,2-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018626 GO:0018629 biolink:MolecularActivity 2-hydroxyquinoline 5,6-dioxygenase activity Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. EC:1.14.12.16|MetaCyc:1.14.12.16-RXN|RHEA:10976|UM-BBD_reactionID:r0052 go.json 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity|quinolin-2(1H)-one 5,6-dioxygenase activity|quinolin-2-ol 5,6-dioxygenase activity|quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating) http://purl.obolibrary.org/obo/GO_0018629 GO:0018628 biolink:MolecularActivity terephthalate 1,2-dioxygenase activity Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+. EC:1.14.12.15|KEGG_REACTION:R05148|MetaCyc:1.14.12.15-RXN|RHEA:10312|UM-BBD_reactionID:r0150 go.json 1,4-dicarboxybenzoate 1,2-dioxygenase activity|benzene-1,4-dicarboxylate 1,2-dioxygenase activity|benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating) http://purl.obolibrary.org/obo/GO_0018628 GO:0018623 biolink:MolecularActivity benzoate 1,2-dioxygenase activity Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+. EC:1.14.12.10|MetaCyc:BENZOATE-12-DIOXYGENASE-RXN|RHEA:12633|UM-BBD_enzymeID:e0154 go.json benzoate dioxygenase activity|benzoate hydroxylase activity|benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)|benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)|benzoic hydroxylase activity http://purl.obolibrary.org/obo/GO_0018623 GO:0018622 biolink:MolecularActivity 4-chlorophenylacetate 3,4-dioxygenase activity Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+. EC:1.14.12.9|KEGG_REACTION:R03306|MetaCyc:1.14.12.9-RXN|RHEA:14689|UM-BBD_reactionID:r0308 go.json 4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating) http://purl.obolibrary.org/obo/GO_0018622 GO:0018625 biolink:MolecularActivity naphthalene 1,2-dioxygenase activity Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+. EC:1.14.12.12|MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN|RHEA:19173|UM-BBD_enzymeID:e0002 go.json naphthalene dioxygenase activity|naphthalene oxygenase activity|naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating) http://purl.obolibrary.org/obo/GO_0018625 GO:0018624 biolink:MolecularActivity toluene dioxygenase activity Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+. EC:1.14.12.11|KEGG_REACTION:R03559|MetaCyc:TOLUENE-DIOXYGENASE-RXN|RHEA:16737|UM-BBD_enzymeID:e0155 go.json toluene 1,2-dioxygenase activity|toluene 2,3-dioxygenase activity|toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating) http://purl.obolibrary.org/obo/GO_0018624 GO:0018621 biolink:MolecularActivity 4-sulfobenzoate 3,4-dioxygenase activity Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite. EC:1.14.12.8|KEGG_REACTION:R01636|MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN|RHEA:13937|UM-BBD_reactionID:r0293 go.json 4-sulfobenzoate 3,4-dioxygenase system|4-sulfobenzoate dioxygenase activity|4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)|4-sulphobenzoate 3,4-dioxygenase activity http://purl.obolibrary.org/obo/GO_0018621 GO:0018620 biolink:MolecularActivity phthalate 4,5-dioxygenase activity Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+. EC:1.14.12.7|KEGG_REACTION:R03630|MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN|RHEA:17489|UM-BBD_reactionID:r0102 go.json PDO activity|phthalate dioxygenase activity|phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating) http://purl.obolibrary.org/obo/GO_0018620 GO:0018638 biolink:MolecularActivity toluene 4-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene. EC:1.14.13.-|UM-BBD_enzymeID:e0225 go.json http://purl.obolibrary.org/obo/GO_0018638 GO:0018637 biolink:MolecularActivity 1-hydroxy-2-naphthoate hydroxylase activity Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NAD(P)H + 2 H+ = NAD(P)+ + H2O + CO2 + 1,2-dihydroxynaphthalene. EC:1.14.13.135|UM-BBD_reactionID:r0491 go.json http://purl.obolibrary.org/obo/GO_0018637 GO:0018639 biolink:MolecularActivity xylene monooxygenase activity Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol. EC:1.14.13.-|UM-BBD_enzymeID:e0172 go.json http://purl.obolibrary.org/obo/GO_0018639 GO:0018634 biolink:MolecularActivity alpha-pinene monooxygenase [NADH] activity Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide. EC:1.14.13.-|UM-BBD_reactionID:r0742 go.json http://purl.obolibrary.org/obo/GO_0018634 GO:0018633 biolink:MolecularActivity dimethyl sulfide monooxygenase activity Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde. EC:1.14.13.-|UM-BBD_reactionID:r0208 go.json dimethyl sulphide monooxygenase activity http://purl.obolibrary.org/obo/GO_0018633 GO:0018636 biolink:MolecularActivity phenanthrene 9,10-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. EC:1.14.13.-|UM-BBD_reactionID:r0495 go.json http://purl.obolibrary.org/obo/GO_0018636 GO:0018635 biolink:MolecularActivity (R)-limonene 1,2-monooxygenase activity Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide. EC:1.14.13.107|KEGG_REACTION:R06398|KEGG_REACTION:R09393|MetaCyc:RXN-9407|UM-BBD_reactionID:r0733 go.json (+)-limonene 1,2-monooxygenase activity|(+)-limonene,NAD(P)H:oxygen oxidoreductase activity|(R)-limonene,NAD(P)H:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0018635 GO:0018630 biolink:MolecularActivity 3,5-xylenol methylhydroxylase activity Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol. EC:1.14.13.-|MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN|UM-BBD_reactionID:r0081 go.json http://purl.obolibrary.org/obo/GO_0018630 GO:0018632 biolink:MolecularActivity 4-nitrophenol 4-monooxygenase activity Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone. EC:1.14.13.167|MetaCyc:RXN-8739|RHEA:34327|UM-BBD_reactionID:r0226 go.json http://purl.obolibrary.org/obo/GO_0018632 GO:0018631 biolink:MolecularActivity phenylacetate hydroxylase activity Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate. EC:1.14.13.-|UM-BBD_reactionID:r0036 go.json http://purl.obolibrary.org/obo/GO_0018631 GO:0018609 biolink:MolecularActivity chlorobenzene dioxygenase activity Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene). EC:1.14.12.-|UM-BBD_enzymeID:e0062 go.json http://purl.obolibrary.org/obo/GO_0018609 GO:0018608 biolink:MolecularActivity 1-indanone dioxygenase activity Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone. EC:1.14.12.-|UM-BBD_reactionID:r0416 go.json http://purl.obolibrary.org/obo/GO_0018608 GO:0018605 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018605 GO:0018604 biolink:MolecularActivity 4-aminobenzoate 3,4-dioxygenase (deaminating) activity Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate. EC:1.14.12.-|UM-BBD_reactionID:r0566 go.json http://purl.obolibrary.org/obo/GO_0018604 GO:0018607 biolink:MolecularActivity 1-indanone monooxygenase activity Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin. EC:1.14.12.-|UM-BBD_reactionID:r0417 go.json http://purl.obolibrary.org/obo/GO_0018607 GO:0018606 biolink:MolecularActivity benzenesulfonate dioxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol. EC:1.14.12.-|UM-BBD_reactionID:r0295 go.json benzenesulphonate dioxygenase activity http://purl.obolibrary.org/obo/GO_0018606 GO:0018601 biolink:MolecularActivity 4-nitrophenol 2-monooxygenase activity Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+. EC:1.14.13.29|KEGG_REACTION:R03023|MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN|RHEA:12568|UM-BBD_reactionID:r0230 go.json 4-nitrophenol hydroxylase activity|4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)|4-nitrophenol-2-hydroxylase activity http://purl.obolibrary.org/obo/GO_0018601 GO:0018600 biolink:MolecularActivity alpha-pinene dehydrogenase activity Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol. EC:1.14.-.-|UM-BBD_reactionID:r0709 go.json http://purl.obolibrary.org/obo/GO_0018600 GO:0018603 biolink:MolecularActivity nitrobenzene 1,2-dioxygenase activity Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol. EC:1.14.12.-|UM-BBD_reactionID:r0306 go.json http://purl.obolibrary.org/obo/GO_0018603 GO:0018602 biolink:MolecularActivity 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2. MetaCyc:RXN-9863|RHEA:48984|UM-BBD_reactionID:r0274 go.json http://purl.obolibrary.org/obo/GO_0018602 GO:0018619 biolink:MolecularActivity benzene 1,2-dioxygenase activity Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+. EC:1.14.12.3|KEGG_REACTION:R03543|MetaCyc:BENZENE-12-DIOXYGENASE-RXN|RHEA:13813|UM-BBD_reactionID:r0079 go.json benzene dioxygenase activity|benzene hydroxylase activity|benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating) http://purl.obolibrary.org/obo/GO_0018619 GO:0018616 biolink:MolecularActivity trihydroxytoluene dioxygenase activity Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate. MetaCyc:R305-RXN|UM-BBD_reactionID:r0093 go.json http://purl.obolibrary.org/obo/GO_0018616 GO:0018615 biolink:MolecularActivity 2-indanone monooxygenase activity Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone. EC:1.14.12.-|UM-BBD_reactionID:r0424 go.json http://purl.obolibrary.org/obo/GO_0018615 GO:0018618 biolink:MolecularActivity anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3. EC:1.14.12.1|MetaCyc:1.14.12.1-RXN|UM-BBD_reactionID:r0577 go.json AntA|AntB|AntC|anthranilate 1,2-dioxygenase|anthranilate dioxygenase activity|anthranilate dioxygenase reductase|anthranilate hydroxylase activity|anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)|anthranilic acid hydroxylase activity|anthranilic hydroxylase activity http://purl.obolibrary.org/obo/GO_0018618 GO:0018617 biolink:MolecularActivity 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol. EC:1.14.12.-|UM-BBD_reactionID:r0580 go.json 4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity http://purl.obolibrary.org/obo/GO_0018617 GO:0018612 biolink:MolecularActivity dibenzothiophene dioxygenase activity Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene. EC:1.14.12.-|UM-BBD_reactionID:r0160 go.json http://purl.obolibrary.org/obo/GO_0018612 GO:0018611 biolink:MolecularActivity toluate dioxygenase activity Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate. EC:1.14.12.-|UM-BBD_enzymeID:e0190 go.json http://purl.obolibrary.org/obo/GO_0018611 GO:0018614 biolink:MolecularActivity ethylbenzene dioxygenase activity Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene. EC:1.14.12.-|UM-BBD_reactionID:r0247 go.json http://purl.obolibrary.org/obo/GO_0018614 GO:0018613 biolink:MolecularActivity 9-fluorenone dioxygenase activity Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone. EC:1.14.12.-|UM-BBD_reactionID:r0409 go.json http://purl.obolibrary.org/obo/GO_0018613 GO:0018610 biolink:MolecularActivity dibenzofuran 4,4a-dioxygenase activity Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+. MetaCyc:R606-RXN|RHEA:42460|UM-BBD_enzymeID:e0030 go.json http://purl.obolibrary.org/obo/GO_0018610 GO:0102630 biolink:MolecularActivity gossypetin 8-methyl ester 3'-O-methyltransferase activity Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine = gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15536 go.json http://purl.obolibrary.org/obo/GO_0102630 GO:0102632 biolink:MolecularActivity (S)-nandinine synthase activity Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. EC:1.14.19.73|MetaCyc:RXN-15538|RHEA:50364 go.json http://purl.obolibrary.org/obo/GO_0102632 GO:0102631 biolink:MolecularActivity caffeoylglucose 3-O-methyltransferase activity Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine = 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15537 go.json http://purl.obolibrary.org/obo/GO_0102631 GO:0102634 biolink:MolecularActivity 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 = flaviolin-2-olate + H2O + H+. MetaCyc:RXN-15586 go.json http://purl.obolibrary.org/obo/GO_0102634 GO:0102633 biolink:MolecularActivity flaviolin monooxygenase activity Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 = mompain + NAD + H2O. MetaCyc:RXN-15585 go.json http://purl.obolibrary.org/obo/GO_0102633 GO:0102636 biolink:MolecularActivity obsolete 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity OBSOLETE. Catalysis of the reaction: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine = 3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-prolinate. go.json True http://purl.obolibrary.org/obo/GO_0102636 GO:0102635 biolink:MolecularActivity 11-deoxycorticosterone reductase activity Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ = 4-pregnen-20,21-diol-3-one + NAD. MetaCyc:RXN-15607|RHEA:47716 go.json http://purl.obolibrary.org/obo/GO_0102635 GO:0102638 biolink:MolecularActivity [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid. EC:2.5.1.105|MetaCyc:RXN-15734 go.json http://purl.obolibrary.org/obo/GO_0102638 GO:0102637 biolink:MolecularActivity 5-aminolevulinate-CoA ligase activity Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP = 5-aminolevulinyl-CoA + AMP + diphosphoric acid. MetaCyc:RXN-15714 go.json http://purl.obolibrary.org/obo/GO_0102637 GO:0102639 biolink:MolecularActivity paspalicine synthase activity Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ = paspalicine + NADP + 2 H2O. MetaCyc:RXN-15737 go.json http://purl.obolibrary.org/obo/GO_0102639 GO:0102641 biolink:MolecularActivity (R)-lactaldehyde dehydrogenase activity Catalysis of the reaction: (R)-propane-1,2-diol + NADP = (R)-lactaldehyde + NADPH + H+. MetaCyc:RXN-15743 go.json http://purl.obolibrary.org/obo/GO_0102641 GO:0102640 biolink:MolecularActivity paspalinine synthase activity Catalysis of the reaction: paspalicine + O2 + NADPH + H+ = paspalinine + NADP + H2O. MetaCyc:RXN-15738 go.json http://purl.obolibrary.org/obo/GO_0102640 GO:0102643 biolink:MolecularActivity scalarane-17alpha-19-diol synthase activity Catalysis of the reaction: scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O. MetaCyc:RXN-15755 go.json http://purl.obolibrary.org/obo/GO_0102643 GO:0102645 biolink:MolecularActivity 17(E)-cheilanthenediol synthase activity Catalysis of the reaction: 17(E)-cheilanthenediol = all-trans-geranylfarnesol + H2O. MetaCyc:RXN-15758 go.json http://purl.obolibrary.org/obo/GO_0102645 GO:0102644 biolink:MolecularActivity monocyclic sesterterpenediol synthase activity Catalysis of the reaction: monocyclic sesterterpenediol = all-trans-geranylfarnesol + H2O. MetaCyc:RXN-15756 go.json http://purl.obolibrary.org/obo/GO_0102644 GO:0102647 biolink:MolecularActivity D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate. MetaCyc:RXN-15789 go.json http://purl.obolibrary.org/obo/GO_0102647 GO:0102646 biolink:MolecularActivity 14betaH-scalarane-17alpha-19-diol synthase activity Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O. MetaCyc:RXN-15759 go.json http://purl.obolibrary.org/obo/GO_0102646 GO:0102649 biolink:MolecularActivity acetoacetyl-ACP synthase activity Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] = acetoacetyl-ACP + 2 coenzyme A + carbon dioxide. MetaCyc:RXN-15810 go.json http://purl.obolibrary.org/obo/GO_0102649 GO:0102648 biolink:MolecularActivity D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate. MetaCyc:RXN-15790 go.json http://purl.obolibrary.org/obo/GO_0102648 GO:0102650 biolink:MolecularActivity cyclo-acetoacetyl-L-tryptophan synthetase activity Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP = cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]. MetaCyc:RXN-15811 go.json http://purl.obolibrary.org/obo/GO_0102650 GO:0004187 biolink:MolecularActivity obsolete carboxypeptidase D activity OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents. go.json CPDW-II|KEX1 carboxypeptidase activity|KEX1 proteinase activity|KEX1DELTAp|carboxypeptidase D activity|carboxypeptidase KEX1 activity|carboxypeptidase Kex1|carboxypeptidase S1 activity|cereal serine carboxypeptidase II|gene KEX1 serine carboxypeptidase|saccharomyces cerevisiae KEX1 gene product True http://purl.obolibrary.org/obo/GO_0004187 GO:0102652 biolink:MolecularActivity gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 = gibberellin A51 + succinate + carbon dioxide. MetaCyc:RXN-171 go.json http://purl.obolibrary.org/obo/GO_0102652 GO:0004186 biolink:MolecularActivity obsolete carboxypeptidase C activity OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity. go.json carboxypeptidase C activity|carboxypeptidase Y activity|cathepsin A activity|deamidase|lysosomal carboxypeptidase A|lysosomal protective protein activity|serine carboxypeptidase I activity|serine-type carboxypeptidase I activity|vacuolar carboxypeptidase Y True http://purl.obolibrary.org/obo/GO_0004186 GO:0102654 biolink:MolecularActivity 1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor = 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.43|MetaCyc:RXN-1725|RHEA:46764 go.json http://purl.obolibrary.org/obo/GO_0102654 GO:0004189 biolink:MolecularActivity obsolete tubulinyl-Tyr carboxypeptidase activity OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr. go.json TTCPase activity|brain I carboxypeptidase activity|carboxypeptidase-tubulin activity|soluble carboxypeptidase activity|tubulin carboxypeptidase activity|tubulin-tyrosine carboxypeptidase activity|tubulinyl-Tyr carboxypeptidase activity|tubulinyl-tyrosine carboxypeptidase activity|tubulinyltyrosine carboxypeptidase activity|tyrosinotubulin carboxypeptidase activity|tyrosyltubulin carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0004189 GO:0004188 biolink:MolecularActivity obsolete serine-type Pro-X carboxypeptidase activity OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid. go.json PCP|aminoacylproline carboxypeptidase activity|angiotensinase C activity|lysosomal Pro-X carboxypeptidase activity|lysosomal Pro-Xaa carboxypeptidase activity|lysosomal carboxypeptidase C activity|peptidylprolylamino acid carboxypeptidase activity|proline carboxypeptidase activity|proline-specific carboxypeptidase P|prolyl carboxypeptidase activity|serine-type Pro-X carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0004188 GO:0102653 biolink:MolecularActivity gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 = H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O. MetaCyc:RXN-172 go.json http://purl.obolibrary.org/obo/GO_0102653 GO:0004183 biolink:MolecularActivity obsolete carboxypeptidase E activity OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents. go.json carboxypeptidase E activity|carboxypeptidase H activity|cobalt-stimulated chromaffin granule carboxypeptidase activity|enkephalin convertase activity|enkephalin precursor carboxypeptidase activity|enkephalin-precursor endopeptidase activity|insulin granule-associated carboxypeptidase activity|membrane-bound carboxypeptidase activity|peptidyl-L-lysine(-L-arginine) hydrolase True http://purl.obolibrary.org/obo/GO_0004183 GO:0102656 biolink:MolecularActivity 1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. MetaCyc:RXN-1727 go.json http://purl.obolibrary.org/obo/GO_0102656 GO:0004182 biolink:MolecularActivity obsolete carboxypeptidase A activity OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. go.json carboxypeptidase A activity|carboxypolypeptidase activity|pancreatic carboxypeptidase A|tissue carboxypeptidase A True http://purl.obolibrary.org/obo/GO_0004182 GO:0102655 biolink:MolecularActivity 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.23|MetaCyc:RXN-1726 go.json http://purl.obolibrary.org/obo/GO_0102655 GO:0004185 biolink:MolecularActivity serine-type carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). EC:3.4.16.-|Reactome:R-HSA-158251 go.json serine carboxypeptidase activity http://purl.obolibrary.org/obo/GO_0004185 GO:0102658 biolink:MolecularActivity 2-oxo-5-methylthiopentanoate aminotransferase activity Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid = L-homomethionine + a 2-oxo carboxylate. MetaCyc:RXN-2205 go.json http://purl.obolibrary.org/obo/GO_0102658 GO:0004184 biolink:MolecularActivity obsolete lysine carboxypeptidase activity OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma. go.json CPase N|anaphylatoxin inactivator activity|arginine carboxypeptidase activity|bradykinase activity|bradykinin-decomposing enzyme|carboxypeptidase N activity|creatine kinase conversion factor|creatinine kinase convertase activity|hippuryllysine hydrolase activity|kininase I activity|kininase Ia|lysine (arginine) carboxypeptidase activity|lysine carboxypeptidase activity|lysine(arginine) carboxypeptidase activity|peptidyl-L-lysine(-L-arginine) hydrolase|plasma carboxypeptidase B True http://purl.obolibrary.org/obo/GO_0004184 GO:0102657 biolink:MolecularActivity 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. EC:1.14.19.42|MetaCyc:RXN-1728 go.json http://purl.obolibrary.org/obo/GO_0102657 GO:0004190 biolink:MolecularActivity aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. EC:3.4.23.-|Reactome:R-HSA-157353|Reactome:R-HSA-157640|Reactome:R-HSA-2022403|Reactome:R-HSA-2022412|Reactome:R-HSA-2065357|Reactome:R-HSA-2220988|Reactome:R-HSA-373705|Reactome:R-HSA-9013361|Reactome:R-HSA-9017817|Reactome:R-HSA-9604294 go.json aspartate protease activity|aspartic endopeptidase activity|aspartic protease activity|aspartyl protease activity|carboxyl protease activity http://purl.obolibrary.org/obo/GO_0004190 GO:0102659 biolink:MolecularActivity UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate = H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP. EC:2.4.1.195|MetaCyc:RXN-2208 go.json http://purl.obolibrary.org/obo/GO_0102659 GO:0004192 biolink:MolecularActivity obsolete cathepsin D activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin. go.json cathepsin D activity True http://purl.obolibrary.org/obo/GO_0004192 GO:0004191 biolink:MolecularActivity obsolete barrierpepsin activity OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor. go.json Bar proteinase activity|barrier proteinase activity|barrierpepsin activity|extracellular 'barrier' protein activity True http://purl.obolibrary.org/obo/GO_0004191 GO:0102661 biolink:MolecularActivity homogentisate solanyltransferase activity Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ = 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid. EC:2.5.1.117|MetaCyc:RXN-2761|RHEA:37995 go.json http://purl.obolibrary.org/obo/GO_0102661 GO:0102660 biolink:MolecularActivity caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity Catalysis of the reaction: caffeoylshikimate + coenzyme A = caffeoyl-CoA + shikimate. MetaCyc:RXN-2621 go.json http://purl.obolibrary.org/obo/GO_0102660 GO:0004198 biolink:MolecularActivity calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. Reactome:R-HSA-8848658|Reactome:R-HSA-8863012 go.json calpain activity http://purl.obolibrary.org/obo/GO_0004198 GO:0102663 biolink:MolecularActivity gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 = H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O. MetaCyc:RXN-292 go.json http://purl.obolibrary.org/obo/GO_0102663 GO:0004197 biolink:MolecularActivity cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. EC:3.4.22.-|Reactome:R-HSA-114252|Reactome:R-HSA-114259|Reactome:R-HSA-114261|Reactome:R-HSA-1236948|Reactome:R-HSA-139898|Reactome:R-HSA-139952|Reactome:R-HSA-1678920|Reactome:R-HSA-1678981|Reactome:R-HSA-201595|Reactome:R-HSA-201603|Reactome:R-HSA-201608|Reactome:R-HSA-201611|Reactome:R-HSA-201622|Reactome:R-HSA-201628|Reactome:R-HSA-201629|Reactome:R-HSA-201630|Reactome:R-HSA-201631|Reactome:R-HSA-201634|Reactome:R-HSA-201636|Reactome:R-HSA-201637|Reactome:R-HSA-201639|Reactome:R-HSA-201640|Reactome:R-HSA-2028692|Reactome:R-HSA-2028697|Reactome:R-HSA-202917|Reactome:R-HSA-202939|Reactome:R-HSA-202947|Reactome:R-HSA-202960|Reactome:R-HSA-202966|Reactome:R-HSA-202967|Reactome:R-HSA-202969|Reactome:R-HSA-211186|Reactome:R-HSA-211190|Reactome:R-HSA-211651|Reactome:R-HSA-212552|Reactome:R-HSA-2130336|Reactome:R-HSA-2130349|Reactome:R-HSA-2130504|Reactome:R-HSA-2130706|Reactome:R-HSA-2562564|Reactome:R-HSA-264865|Reactome:R-HSA-264871|Reactome:R-HSA-3465448|Reactome:R-HSA-350158|Reactome:R-HSA-350318|Reactome:R-HSA-350319|Reactome:R-HSA-350651|Reactome:R-HSA-351849|Reactome:R-HSA-351871|Reactome:R-HSA-351876|Reactome:R-HSA-351877|Reactome:R-HSA-351894|Reactome:R-HSA-351901|Reactome:R-HSA-351913|Reactome:R-HSA-351936|Reactome:R-HSA-352268|Reactome:R-HSA-418845|Reactome:R-HSA-418846|Reactome:R-HSA-418852|Reactome:R-HSA-448703|Reactome:R-HSA-5357828|Reactome:R-HSA-5634228|Reactome:R-HSA-5660663|Reactome:R-HSA-5681987|Reactome:R-HSA-5682377|Reactome:R-HSA-6814387|Reactome:R-HSA-9012556|Reactome:R-HSA-9013895|Reactome:R-HSA-933532|Reactome:R-HSA-9603534|Reactome:R-HSA-9647632|Reactome:R-HSA-9647680|Reactome:R-HSA-9647999|Reactome:R-HSA-9684273|Reactome:R-HSA-9684309|Reactome:R-HSA-9684321|Reactome:R-HSA-9684336|Reactome:R-HSA-9684340|Reactome:R-HSA-9684351|Reactome:R-HSA-9684352|Reactome:R-HSA-9686088|Reactome:R-HSA-9686930|Reactome:R-HSA-9693929|Reactome:R-HSA-9694338|Reactome:R-HSA-9694377|Reactome:R-HSA-9694441|Reactome:R-HSA-9694551|Reactome:R-HSA-9694601|Reactome:R-HSA-9694625|Reactome:R-HSA-9694732|Reactome:R-HSA-9697750|Reactome:R-HSA-9710101|Reactome:R-HSA-9729704|Reactome:R-HSA-9729730|Reactome:R-HSA-9729741 go.json caspase activity|lysosomal cysteine-type endopeptidase|metacaspase activity|thiol endopeptidase activity http://purl.obolibrary.org/obo/GO_0004197 GO:0102662 biolink:MolecularActivity obsolete malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity OBSOLETE. Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) = acetyl-CoA(4-) + carbon dioxide + NADH(2-). go.json True http://purl.obolibrary.org/obo/GO_0102662 GO:0102665 biolink:MolecularActivity indole-3-acetyl-glutamate synthetase activity Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP = H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid. MetaCyc:RXN-2947 go.json http://purl.obolibrary.org/obo/GO_0102665 GO:0004199 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004199 GO:0102664 biolink:MolecularActivity indole-3-acetyl-leucine synthetase activity Catalysis of the reaction: indole-3-acetate + L-leucine + ATP = H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP. MetaCyc:RXN-2945 go.json http://purl.obolibrary.org/obo/GO_0102664 GO:0004194 biolink:MolecularActivity obsolete pepsin A activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin. go.json P I|P II|elixir lactate of pepsin|fundus-pepsin|lactated pepsin|lactated pepsin elixir|pepsin A activity|pepsin D|pepsin R|pepsin activity|pepsin fortior True http://purl.obolibrary.org/obo/GO_0004194 GO:0102667 biolink:MolecularActivity indole-3-acetyl-beta-1-D-glucose hydrolase activity Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O = H+ + indole-3-acetate + beta-D-glucose. MetaCyc:RXN-3165 go.json http://purl.obolibrary.org/obo/GO_0102667 GO:0004193 biolink:MolecularActivity obsolete cathepsin E activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity. go.json EMAP|SMP|cathepsin D-like acid proteinase activity|cathepsin D-type proteinase activity|cathepsin E activity|cathepsin E-like acid proteinase activity|erythrocyte membrane aspartic proteinase activity|non-pepsin proteinase activity|slow-moving proteinase activity True http://purl.obolibrary.org/obo/GO_0004193 GO:0102666 biolink:MolecularActivity indole-3-acetyl-beta-4-D-glucose hydrolase activity Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O = H+ + indole-3-acetate + beta-D-glucose. MetaCyc:RXN-3164 go.json http://purl.obolibrary.org/obo/GO_0102666 GO:0004196 biolink:MolecularActivity obsolete saccharopepsin activity OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24. go.json PRA|Saccharomyces aspartic proteinase activity|aspartic proteinase yscA|proteinase A|proteinase yscA|saccharomyces aspartic proteinase activity|saccharomyces cerevisiae aspartic proteinase A|saccharopepsin activity|yeast endopeptidase A activity|yeast proteinase A True http://purl.obolibrary.org/obo/GO_0004196 GO:0102669 biolink:MolecularActivity isoflavone-7-O-glucoside beta-glucosidase activity Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O = daidzein + beta-D-glucose. MetaCyc:RXN-3591 go.json http://purl.obolibrary.org/obo/GO_0102669 GO:0004195 biolink:MolecularActivity obsolete renin activity OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I. go.json angiotensin-forming enzyme activity|angiotensinogenase activity|renin activity True http://purl.obolibrary.org/obo/GO_0004195 GO:0102668 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102668 GO:0004169 biolink:MolecularActivity dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. EC:2.4.1.109|MetaCyc:2.4.1.109-RXN|Reactome:R-HSA-5615556|Reactome:R-HSA-5615604|Reactome:R-HSA-5615637 go.json O-glycoside mannosyltransferase|dolichol phosphomannose-protein mannosyltransferase activity|dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein O-mannosyltransferase activity|protein O-D-mannosyltransferase activity|protein O-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0004169 GO:0004168 biolink:MolecularActivity dolichol kinase activity Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. EC:2.7.1.108|MetaCyc:DOLICHOL-KINASE-RXN|RHEA:13133|Reactome:R-HSA-446195|Reactome:R-HSA-4755600 go.json CTP:dolichol O-phosphotransferase activity|dolichol phosphokinase activity http://purl.obolibrary.org/obo/GO_0004168 GO:0004165 biolink:MolecularActivity delta(3)-delta(2)-enoyl-CoA isomerase activity Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA. EC:5.3.3.8|RHEA:45900|Reactome:R-HSA-109338|Reactome:R-HSA-6809808 go.json 3,2-trans-enoyl-CoA isomerase activity|acetylene-allene isomerase activity|delta(3),delta(2)-enoyl-CoA isomerase activity|delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity|delta3,delta2-enoyl-CoA isomerase activity|delta3-cis-delta2-trans-enoyl-CoA isomerase|delta3-delta2 enoyl-CoA isomerase activity|dodecenoyl-CoA (3Z)-(2E)-isomerase activity|dodecenoyl-CoA D-isomerase activity|dodecenoyl-CoA delta-isomerase activity|dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity|dodecenoyl-CoA isomerase activity http://purl.obolibrary.org/obo/GO_0004165 GO:0004164 biolink:MolecularActivity diphthine synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. EC:2.1.1.98|MetaCyc:RXN-11370|RHEA:36415|Reactome:R-HSA-5358484 go.json S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity|S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity|diphthine methyltransferase activity http://purl.obolibrary.org/obo/GO_0004164 GO:0004167 biolink:MolecularActivity dopachrome isomerase activity Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. EC:5.3.3.12|KEGG_REACTION:R03673|MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN|RHEA:13041 go.json DCF activity|DCT activity|L-dopachrome isomerase activity|L-dopachrome keto-enol isomerase activity|L-dopachrome-methyl ester tautomerase activity|TRP activity|TRP-1|TRP-2|TRP2|dopachrome Delta(7),Delta(2)-isomerase activity|dopachrome conversion activity|dopachrome conversion factor activity|dopachrome delta-isomerase activity|dopachrome delta7,Delta2-isomerase activity|dopachrome keto-enol isomerase activity|dopachrome oxidoreductase activity|dopachrome rearranging enzyme activity|dopachrome tautomerase activity|dopachrome-rearranging enzyme|tryosinase-related protein-2|tyrosinase-related protein 2 activity http://purl.obolibrary.org/obo/GO_0004167 GO:0004166 biolink:MolecularActivity dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate. EC:2.4.1.153|MetaCyc:2.4.1.153-RXN|RHEA:14693 go.json UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity|UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity|dolichyl phosphate N-acetylglucosaminyltransferase activity|dolichyl phosphate acetylglucosaminyltransferase activity|dolichyl-phosphate N-acetylglucosaminyltransferase activity|dolichyl-phosphate acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0004166 GO:0004161 biolink:MolecularActivity dimethylallyltranstransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. EC:2.5.1.1|MetaCyc:GPPSYN-RXN|RHEA:22408|Reactome:R-HSA-191322|Reactome:R-HSA-9717834 go.json (2E,6E)-farnesyl diphosphate synthetase activity|DMAPP:IPP-dimethylallyltransferase activity|dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity|dimethylallyltransferase activity|diprenyltransferase activity|geranyl diphosphate synthase|geranyl pyrophosphate synthase activity|geranyl pyrophosphate synthetase activity|geranyl-diphosphate synthase activity|trans-farnesyl pyrophosphate synthetase activity http://purl.obolibrary.org/obo/GO_0004161 GO:0004160 biolink:MolecularActivity dihydroxy-acid dehydratase activity Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. EC:4.2.1.9|MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN|RHEA:20936 go.json 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)|2,3-dihydroxy-acid hydro-lyase activity|2,3-dihydroxyisovalerate dehydratase activity|DHAD|acetohydroxyacid dehydratase activity|alpha,beta-dihydroxyacid dehydratase activity|alpha,beta-dihydroxyisovalerate dehydratase activity|dihydroxy acid dehydrase activity http://purl.obolibrary.org/obo/GO_0004160 GO:0004163 biolink:MolecularActivity diphosphomevalonate decarboxylase activity Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate. EC:4.1.1.33|KEGG_REACTION:R01121|MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN|RHEA:23732|Reactome:R-HSA-191414 go.json 5-pyrophosphomevalonate decarboxylase activity|ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)|ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)|mevalonate 5-diphosphate decarboxylase activity|mevalonate diphosphate decarboxylase activity|mevalonate pyrophosphate decarboxylase activity|mevalonate-5-pyrophosphate decarboxylase activity|pyrophosphomevalonate decarboxylase activity|pyrophosphomevalonic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0004163 GO:0004162 biolink:MolecularActivity dimethylnitrosamine demethylase activity Catalysis of the removal of a methyl group from N-nitrosodimethylamine. go.json N-nitrosodimethylamine demethylase activity http://purl.obolibrary.org/obo/GO_0004162 GO:0004170 biolink:MolecularActivity dUTP diphosphatase activity Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate. EC:3.6.1.23|KEGG_REACTION:R02100|MetaCyc:DUTP-PYROP-RXN|RHEA:10248|Reactome:R-HSA-73666 go.json dUTP nucleotidohydrolase activity|dUTP pyrophosphatase activity|dUTPase activity|deoxyuridine-triphosphatase activity|desoxyuridine 5'-triphosphatase activity|desoxyuridine 5'-triphosphate nucleotidohydrolase activity http://purl.obolibrary.org/obo/GO_0004170 goslim_chembl GO:0004179 biolink:MolecularActivity obsolete membrane alanyl aminopeptidase activity OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. EC:3.4.11.2|MetaCyc:3.4.11.2-RXN go.json CD13|L-alanine aminopeptidase activity|alanine-specific aminopeptidase activity|alanyl aminopeptidase activity|amino-oligopeptidase activity|aminopeptidase M activity|aminopeptidase N activity|cysteinylglycinase activity|cysteinylglycine dipeptidase activity|membrane alanine aminopeptidase activity|membrane alanyl aminopeptidase activity|membrane aminopeptidase I activity|microsomal aminopeptidase activity|particle-bound aminopeptidase activity|peptidase E activity|pseudo leucine aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0004179 GO:0004176 biolink:MolecularActivity ATP-dependent peptidase activity Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. Reactome:R-HSA-9698929 go.json ATP-dependent proteolysis http://purl.obolibrary.org/obo/GO_0004176 GO:0004175 biolink:MolecularActivity endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. Reactome:R-HSA-1168640|Reactome:R-HSA-1234159|Reactome:R-HSA-1236935|Reactome:R-HSA-1236970|Reactome:R-HSA-1251997|Reactome:R-HSA-1433374|Reactome:R-HSA-1504193|Reactome:R-HSA-174058|Reactome:R-HSA-174105|Reactome:R-HSA-174202|Reactome:R-HSA-174203|Reactome:R-HSA-174255|Reactome:R-HSA-180573|Reactome:R-HSA-180603|Reactome:R-HSA-187574|Reactome:R-HSA-188191|Reactome:R-HSA-193682|Reactome:R-HSA-209061|Reactome:R-HSA-211715|Reactome:R-HSA-2130282|Reactome:R-HSA-2213200|Reactome:R-HSA-264458|Reactome:R-HSA-353125|Reactome:R-HSA-3640874|Reactome:R-HSA-3928656|Reactome:R-HSA-450466|Reactome:R-HSA-4608855|Reactome:R-HSA-4641256|Reactome:R-HSA-4641260|Reactome:R-HSA-5358340|Reactome:R-HSA-5358460|Reactome:R-HSA-5362448|Reactome:R-HSA-5387392|Reactome:R-HSA-5607724|Reactome:R-HSA-5607731|Reactome:R-HSA-5610754|Reactome:R-HSA-5610757|Reactome:R-HSA-5610758|Reactome:R-HSA-5610760|Reactome:R-HSA-5635854|Reactome:R-HSA-5635868|Reactome:R-HSA-5658430|Reactome:R-HSA-5668481|Reactome:R-HSA-5668520|Reactome:R-HSA-5687112|Reactome:R-HSA-5693081|Reactome:R-HSA-6784628|Reactome:R-HSA-6784676|Reactome:R-HSA-68825|Reactome:R-HSA-68948|Reactome:R-HSA-69016|Reactome:R-HSA-69600|Reactome:R-HSA-74730|Reactome:R-HSA-75825|Reactome:R-HSA-8849797|Reactome:R-HSA-8850992|Reactome:R-HSA-8852354|Reactome:R-HSA-8854044|Reactome:R-HSA-8854071|Reactome:R-HSA-8866553|Reactome:R-HSA-8866858|Reactome:R-HSA-8932355|Reactome:R-HSA-8934819|Reactome:R-HSA-8939801|Reactome:R-HSA-8952408|Reactome:R-HSA-8957265|Reactome:R-HSA-9008110|Reactome:R-HSA-9008475|Reactome:R-HSA-9009362|Reactome:R-HSA-9010096|Reactome:R-HSA-9011313|Reactome:R-HSA-9604642|Reactome:R-HSA-9614271|Reactome:R-HSA-9755303|Reactome:R-HSA-9755306|Reactome:R-HSA-9762096|Reactome:R-HSA-983150|Reactome:R-HSA-983158 go.json elastase activity|endoprotease activity|proteasome endopeptidase activity|proteinase http://purl.obolibrary.org/obo/GO_0004175 GO:0004178 biolink:MolecularActivity obsolete leucyl aminopeptidase activity OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro. EC:3.4.11.1|MetaCyc:3.4.11.1-RXN go.json FTBL proteins|L-leucine aminopeptidase activity|aminopeptidase II|cathepsin III|cytosol aminopeptidase activity|leucinamide aminopeptidase activity|leucinaminopeptidase activity|leucine aminopeptidase activity|leucyl aminopeptidase activity|leucyl peptidase activity|peptidase S activity|proteinates FTBL True http://purl.obolibrary.org/obo/GO_0004178 GO:0004177 biolink:MolecularActivity aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. EC:3.4.11.-|MetaCyc:RXN0-5052|Reactome:R-HSA-1236954|Reactome:R-HSA-2534096|Reactome:R-HSA-8851929|Reactome:R-HSA-983162 go.json http://purl.obolibrary.org/obo/GO_0004177 GO:0004172 biolink:MolecularActivity obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity OBSOLETE. (Was not defined before being made obsolete). go.json ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity True http://purl.obolibrary.org/obo/GO_0004172 GO:0102601 biolink:MolecularActivity cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP. EC:1.14.14.63|MetaCyc:RXN-15385|RHEA:55440 go.json http://purl.obolibrary.org/obo/GO_0102601 GO:0102600 biolink:MolecularActivity cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P). MetaCyc:RXN-15384 go.json http://purl.obolibrary.org/obo/GO_0102600 GO:0004171 biolink:MolecularActivity obsolete deoxyhypusine synthase activity OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. go.json [eIF-5A]-deoxyhypusine synthase|deoxyhypusine synthase activity True http://purl.obolibrary.org/obo/GO_0004171 GO:0004174 biolink:MolecularActivity electron-transferring-flavoprotein dehydrogenase activity Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]. EC:1.5.5.1|MetaCyc:RXN66-550|RHEA:24052|Reactome:R-HSA-169270 go.json ETF dehydrogenase activity|ETF-QO activity|ETF-ubiquinone oxidoreductase activity|ETF:ubiquinone oxidoreductase activity|electron transfer flavoprotein Q oxidoreductase activity|electron transfer flavoprotein dehydrogenase activity|electron transfer flavoprotein reductase activity|electron transfer flavoprotein-ubiquinone oxidoreductase activity|electron-transferring-flavoprotein:ubiquinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004174 GO:0102603 biolink:MolecularActivity 12-demethyl-elloramycin C12a O-methyltransferase activity Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine = elloramycin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15402 go.json http://purl.obolibrary.org/obo/GO_0102603 GO:0004173 biolink:MolecularActivity ecdysone O-acyltransferase activity Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate. EC:2.3.1.139|KEGG_REACTION:R02375|MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN|RHEA:15217 go.json acyl-CoA:ecdysone acyltransferase activity|fatty acyl-CoA:ecdysone acyltransferase activity|palmitoyl-CoA:ecdysone palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0004173 GO:0102602 biolink:MolecularActivity cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P). MetaCyc:RXN-15386 go.json http://purl.obolibrary.org/obo/GO_0102602 GO:0102605 biolink:MolecularActivity cyclooctat-9-en-5,7-diol C18-monooxygenase activity Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ = cyclooctatin + H2O + NADP. MetaCyc:RXN-15430|RHEA:56824 go.json http://purl.obolibrary.org/obo/GO_0102605 GO:0102604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102604 GO:0102607 biolink:MolecularActivity 3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ = 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O. MetaCyc:RXN-15433 go.json http://purl.obolibrary.org/obo/GO_0102607 GO:0004181 biolink:MolecularActivity metallocarboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. EC:3.4.17.-|Reactome:R-HSA-2022378|Reactome:R-HSA-2022379|Reactome:R-HSA-2028294|Reactome:R-HSA-8852809|Reactome:R-HSA-8866105|Reactome:R-HSA-8955712|Reactome:R-HSA-9023159|Reactome:R-HSA-9023163 go.json http://purl.obolibrary.org/obo/GO_0004181 GO:0102606 biolink:MolecularActivity octat-9-en-7-ol 5-monooxygenase activity Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ = cyclooctat-9-en-5,7-diol + H2O + NADP. MetaCyc:RXN-15431|RHEA:56820 go.json http://purl.obolibrary.org/obo/GO_0102606 GO:0004180 biolink:MolecularActivity carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. RHEA:28783|Reactome:R-HSA-1247910|Reactome:R-HSA-9753632 go.json http://purl.obolibrary.org/obo/GO_0004180 GO:0102609 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102609 GO:0102608 biolink:MolecularActivity tetracenomycin B3 8-O-methyl transferase activity Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine = tetracenomycin E + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15435 go.json http://purl.obolibrary.org/obo/GO_0102608 GO:0004147 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004147 GO:0004146 biolink:MolecularActivity dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. EC:1.5.1.3|MetaCyc:DIHYDROFOLATEREDUCT-RXN|RHEA:15009|Reactome:R-HSA-1497794 go.json 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity|7,8-dihydrofolate reductase activity|DHFR|NADPH-dihydrofolate reductase activity|dihydrofolate reductase:thymidylate synthase activity|dihydrofolate reduction|dihydrofolic acid reductase activity|dihydrofolic reductase activity|folic acid reductase activity|folic reductase activity|pteridine reductase:dihydrofolate reductase activity|tetrahydrofolate dehydrogenase activity|thymidylate synthetase-dihydrofolate reductase activity http://purl.obolibrary.org/obo/GO_0004146 GO:0004149 biolink:MolecularActivity dihydrolipoyllysine-residue succinyltransferase activity Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. EC:2.3.1.61|RHEA:15213 go.json dihydrolipoamide S-succinyltransferase activity|dihydrolipoamide succinyltransferase activity|dihydrolipoic transsuccinylase activity|dihydrolipolyl transsuccinylase activity|dihydrolipoyl transsuccinylase activity|enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity|lipoate succinyltransferase (Escherichia coli) activity|lipoate succinyltransferase activity|lipoic transsuccinylase activity|lipoyl transsuccinylase activity|succinyl-CoA:dihydrolipoamide S-succinyltransferase activity|succinyl-CoA:dihydrolipoate S-succinyltransferase activity|succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity|succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity http://purl.obolibrary.org/obo/GO_0004149 GO:0004148 biolink:MolecularActivity dihydrolipoyl dehydrogenase activity Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. EC:1.8.1.4|MetaCyc:1.8.1.4-RXN|RHEA:15045|Reactome:R-HSA-1222412|Reactome:R-HSA-5694018 go.json E3 component of alpha-ketoacid dehydrogenase complexes activity|L-protein activity|LDP-Glc activity|LDP-Val activity|dehydrolipoate dehydrogenase activity|diaphorase activity|dihydrolipoamide dehydrogenase activity|dihydrolipoamide reduction|dihydrolipoamide:NAD+ oxidoreductase|dihydrolipoic dehydrogenase activity|dihydrolipoylprotein reduction|dihydrothioctic dehydrogenase activity|glycine-cleavage system L-protein activity|lipoamide dehydrogenase (NADH) activity|lipoamide oxidoreductase (NADH) activity|lipoamide reductase (NADH) activity|lipoamide reductase activity|lipoate dehydrogenase activity|lipoic acid dehydrogenase activity|lipoyl dehydrogenase activity|protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase|protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase http://purl.obolibrary.org/obo/GO_0004148 GO:0004143 biolink:MolecularActivity ATP-dependent diacylglycerol kinase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. EC:2.7.1.107|MetaCyc:DIACYLGLYKIN-RXN|RHEA:10272|Reactome:R-HSA-426240 go.json DGK activity|diacylglycerol kinase activity|diacylglycerol kinase activity (ATP)|diglyceride kinase activity http://purl.obolibrary.org/obo/GO_0004143 GO:0004142 biolink:MolecularActivity diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. EC:2.7.8.2|MetaCyc:RXN-5781|RHEA:32939|Reactome:R-HSA-1482961|Reactome:R-HSA-1482973 go.json 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity|1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity|1-alkyl-2-acetylglycerol cholinephosphotransferase activity|CDP-choline diglyceride phosphotransferase activity|CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity|CPT|alkylacylglycerol choline phosphotransferase activity|alkylacylglycerol cholinephosphotransferase activity|cholinephosphotransferase activity|cytidine diphosphocholine glyceride transferase activity|cytidine diphosphorylcholine diglyceride transferase activity|diacylglycerol choline phosphotransferase activity|phosphocholine diacylglyceroltransferase activity|phosphorylcholine--glyceride transferase activity|sn-1,2-diacylglycerol cholinephosphotransferase activity http://purl.obolibrary.org/obo/GO_0004142 GO:0004145 biolink:MolecularActivity diamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. EC:2.3.1.57|MetaCyc:DIAMACTRANS-RXN|RHEA:25181|Reactome:R-HSA-351207|Reactome:R-HSA-351208 go.json acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity|acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity|diamine acetyltransferase activity|putrescine (diamine)-acetylating enzyme activity|putrescine N-acetyltransferase activity|putrescine acetylase activity|putrescine acetyltransferase activity|spermidine N(1)-acetyltransferase activity|spermidine N1-acetyltransferase activity|spermidine acetyltransferase activity|spermidine/spermine N1-acetyltransferase activity|spermine N(1)-acetyltransferase|spermine N-acetyltransferase|spermine acetyltransferase http://purl.obolibrary.org/obo/GO_0004145 GO:0102610 biolink:MolecularActivity (+)-secoisolariciresinol glucosyltransferase activity Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose = (+)-secoisolariciresinol monoglucoside + UDP + H+. MetaCyc:RXN-15442 go.json http://purl.obolibrary.org/obo/GO_0102610 GO:0004144 biolink:MolecularActivity diacylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. EC:2.3.1.20|MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN|RHEA:10868|Reactome:R-HSA-1482889|Reactome:R-HSA-549192|Reactome:R-HSA-75900|Reactome:R-HSA-8848580 go.json 1,2-diacylglycerol acyltransferase activity|acyl-CoA:1,2-diacylglycerol O-acyltransferase activity|diacylglycerol acyltransferase activity|diglyceride O-acyltransferase activity|diglyceride acyltransferase activity|palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity http://purl.obolibrary.org/obo/GO_0004144 GO:0102612 biolink:MolecularActivity syn-pimaradiene 6beta-hydroxylase activity Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ = 6beta-hydroxy-syn-pimaradiene + NADP + H2O. MetaCyc:RXN-15452 go.json http://purl.obolibrary.org/obo/GO_0102612 GO:0102611 biolink:MolecularActivity (+)-secoisolariciresinol monoglucoside glucosyltransferase activity Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose = (+)-secoisolariciresinol diglucoside + UDP + H+. MetaCyc:RXN-15443 go.json http://purl.obolibrary.org/obo/GO_0102611 GO:0102614 biolink:MolecularActivity germacrene A acid 8beta-hydroxylase activity Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ = 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O. MetaCyc:RXN-15460 go.json http://purl.obolibrary.org/obo/GO_0102614 GO:0004141 biolink:MolecularActivity dethiobiotin synthase activity Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate. EC:6.3.3.3|KEGG_REACTION:R03182|MetaCyc:DETHIOBIOTIN-SYN-RXN|RHEA:15805 go.json 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)|DTB synthetase activity|desthiobiotin synthase activity http://purl.obolibrary.org/obo/GO_0004141 GO:0004140 biolink:MolecularActivity dephospho-CoA kinase activity Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. EC:2.7.1.24|KEGG_REACTION:R00130|MetaCyc:DEPHOSPHOCOAKIN-RXN|RHEA:18245|Reactome:R-HSA-196773|Reactome:R-HSA-9837337 go.json 3'-dephospho-CoA kinase activity|ATP:dephospho-CoA 3'-phosphotransferase activity|dephosphocoenzyme A kinase (phosphorylating)|dephosphocoenzyme A kinase activity http://purl.obolibrary.org/obo/GO_0004140 GO:0102613 biolink:MolecularActivity trimethyluric acid monooxygenase activity Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ = 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O. MetaCyc:RXN-15454|RHEA:48992 go.json http://purl.obolibrary.org/obo/GO_0102613 GO:0102616 biolink:MolecularActivity obsolete oryzalexin A synthase activity OBSOLETE. Catalysis of the reaction: oryzalexin D + NAD(P) = oryzalexin A + H+ + NAD(P)H. go.json True http://purl.obolibrary.org/obo/GO_0102616 GO:0102615 biolink:MolecularActivity ent-cassadiene-C2-hydroxylase activity Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ = 2alpha-hydroxy-ent-cassadiene + NADP + H2O. MetaCyc:RXN-15462|RHEA:55484 go.json http://purl.obolibrary.org/obo/GO_0102615 GO:0102618 biolink:MolecularActivity obsolete oryzalexin B synthase activity OBSOLETE. Catalysis of the reaction: oryzalexin D + NAD(P) = oryzalexin B + H+ + NAD(P)H. go.json True http://purl.obolibrary.org/obo/GO_0102618 GO:0102617 biolink:MolecularActivity obsolete oryzalexin C synthase (oryzalexin B dependent) activity OBSOLETE. Catalysis of the reaction: oryzalexin B + NAD(P) = oryzalexin C + H+ + NAD(P)H. go.json True http://purl.obolibrary.org/obo/GO_0102617 GO:0018788 biolink:MolecularActivity atrazine chlorohydrolase activity Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H+. EC:3.8.1.8|KEGG_REACTION:R05558|MetaCyc:3.8.1.8-RXN|RHEA:11312|UM-BBD_reactionID:r0113 go.json AtzA http://purl.obolibrary.org/obo/GO_0018788 GO:0102619 biolink:MolecularActivity obsolete oryzalexin C synthase (oryzalexin A dependent) activity OBSOLETE. Catalysis of the reaction: oryzalexin A + NAD(P) = oryzalexin C + H+ + NAD(P)H. go.json True http://purl.obolibrary.org/obo/GO_0102619 GO:0018787 biolink:MolecularActivity 4-chlorobenzoyl-CoA dehalogenase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride. EC:3.8.1.7|MetaCyc:3.8.1.7-RXN|RHEA:14853|UM-BBD_enzymeID:e0113 go.json 4-chlorobenzoyl CoA chlorohydrolase activity http://purl.obolibrary.org/obo/GO_0018787 GO:0018789 biolink:MolecularActivity cyclamate sulfohydrolase activity Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + sulfate. EC:3.10.1.2|KEGG_REACTION:R02564|MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN|RHEA:18481|UM-BBD_reactionID:r0755 go.json cyclamate sulfamatase activity|cyclamate sulfamidase activity|cyclamate sulphohydrolase activity|cyclohexylsulfamate sulfamidase activity|cyclohexylsulfamate sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0018789 GO:0018784 biolink:MolecularActivity (S)-2-haloacid dehalogenase activity Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. EC:3.8.1.2|MetaCyc:2-HALOACID-DEHALOGENASE-RXN|RHEA:11192|UM-BBD_reactionID:r0090 go.json (S)-2-haloacid halidohydrolase activity|2-haloacid dehalogenase activity|2-haloacid halidohydrolase activity|2-haloalkanoic acid dehalogenase activity|2-haloalkanoid acid halidohydrolase activity|2-halocarboxylic acid dehalogenase II activity|DL-2-haloacid dehalogenase activity|L-2-haloacid dehalogenase activity|L-DEX activity|halocarboxylic acid halidohydrolase activity http://purl.obolibrary.org/obo/GO_0018784 GO:0018783 biolink:MolecularActivity deisopropyldeethylatrazine hydrolase activity Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3. go.json http://purl.obolibrary.org/obo/GO_0018783 GO:0018786 biolink:MolecularActivity haloalkane dehalogenase activity Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide. EC:3.8.1.5|MetaCyc:HALOALKANE-DEHALOGENASE-RXN|RHEA:19081|UM-BBD_enzymeID:e0003 go.json 1-chlorohexane halidohydrolase activity|1-haloalkane dehalogenase activity|1-haloalkane halidohydrolase activity http://purl.obolibrary.org/obo/GO_0018786 GO:0018785 biolink:MolecularActivity haloacetate dehalogenase activity Catalysis of the reaction: haloacetate + H2O = glycolate + halide. EC:3.8.1.3|MetaCyc:HALOACETATE-DEHALOGENASE-RXN|RHEA:11044|UM-BBD_enzymeID:e0006 go.json haloacetate halidohydrolase activity|monohaloacetate dehalogenase activity http://purl.obolibrary.org/obo/GO_0018785 GO:0018780 biolink:MolecularActivity dichloroacetate halidohydrolase activity Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate. UM-BBD_reactionID:r0383 go.json http://purl.obolibrary.org/obo/GO_0018780 GO:0018782 biolink:MolecularActivity cis-chloroacrylic acid dehalogenase activity Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde. UM-BBD_reactionID:r0688 go.json http://purl.obolibrary.org/obo/GO_0018782 GO:0018781 biolink:MolecularActivity S-triazine hydrolase activity Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine. UM-BBD_enzymeID:e0091 go.json http://purl.obolibrary.org/obo/GO_0018781 GO:0004158 biolink:MolecularActivity obsolete dihydroorotate oxidase activity OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + O2 = H2O2 + orotate. go.json (S)-dihydroorotate:oxygen oxidoreductase activity|4,5-L-dihydroorotate:oxygen oxidoreductase activity True http://purl.obolibrary.org/obo/GO_0004158 GO:0004157 biolink:MolecularActivity dihydropyrimidinase activity Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. EC:3.5.2.2|MetaCyc:DIHYDROPYRIMIDINASE-RXN|RHEA:16121|Reactome:R-HSA-73589|Reactome:R-HSA-73618 go.json 5,6-dihydropyrimidine amidohydrolase activity|D-hydantoinase activity|hydantoin peptidase activity|hydantoinase activity|hydropyrimidine hydrase activity|pyrimidine hydrase activity http://purl.obolibrary.org/obo/GO_0004157 GO:0004159 biolink:MolecularActivity dihydropyrimidine dehydrogenase (NAD+) activity Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+. EC:1.3.1.1|MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN go.json 5,6-dihydrouracil:NAD+ oxidoreductase activity|dihydrothymine dehydrogenase (NAD+) activity|dihydrouracil dehydrogenase (NAD+) activity|pyrimidine reductase activity|thymine reductase activity|uracil reductase activity http://purl.obolibrary.org/obo/GO_0004159 GO:0004154 biolink:MolecularActivity dihydropterin oxidase activity Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide. go.json http://purl.obolibrary.org/obo/GO_0004154 GO:0004153 biolink:MolecularActivity dihydropterin deaminase activity Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3. go.json http://purl.obolibrary.org/obo/GO_0004153 GO:0102621 biolink:MolecularActivity emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ = 14,15-epoxyemindole-SB + NADP + H2O. MetaCyc:RXN-15496 go.json http://purl.obolibrary.org/obo/GO_0102621 GO:0004156 biolink:MolecularActivity dihydropteroate synthase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. EC:2.5.1.15|MetaCyc:H2PTEROATESYNTH-RXN|RHEA:19949 go.json (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity|2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity|7,8-dihydropteroate synthase activity|7,8-dihydropteroate synthetase activity|7,8-dihydropteroic acid synthetase activity|DHPS activity|dihydropteroate diphosphorylase activity|dihydropteroate pyrophosphorylase activity|dihydropteroate synthetase activity|dihydropteroic synthetase activity http://purl.obolibrary.org/obo/GO_0004156 GO:0004155 biolink:MolecularActivity 6,7-dihydropteridine reductase activity Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. EC:1.5.1.34|MetaCyc:1.5.1.34-RXN|Reactome:R-HSA-71130 go.json 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity|5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity|6,7-dihydropteridine:NAD(P)H oxidoreductase activity|DHPR activity|NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity|NAD(P)H2:6,7-dihydropteridine oxidoreductase activity|NADH-dihydropteridine reductase activity|NADPH-dihydropteridine reductase activity|NADPH-specific dihydropteridine reductase activity|dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity|dihydropteridine reductase (NADH) activity|dihydropteridine reductase activity|dihydropteridine reduction http://purl.obolibrary.org/obo/GO_0004155 GO:0102620 biolink:MolecularActivity 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O. MetaCyc:RXN-15495 go.json http://purl.obolibrary.org/obo/GO_0102620 GO:0102623 biolink:MolecularActivity scutellarein 7-methyl ether 6-O-methyltransferase activity Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine = cirsimaritin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15528 go.json http://purl.obolibrary.org/obo/GO_0102623 GO:0004150 biolink:MolecularActivity dihydroneopterin aldolase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. EC:4.1.2.25|MetaCyc:H2NEOPTERINALDOL-RXN|RHEA:10540 go.json 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)|2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0004150 GO:0102622 biolink:MolecularActivity linuron hydrolase activity Catalysis of the reaction: linuron + H2O = N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline. MetaCyc:RXN-15526 go.json http://purl.obolibrary.org/obo/GO_0102622 GO:0004152 biolink:MolecularActivity dihydroorotate dehydrogenase activity Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. KEGG_REACTION:R01868|MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN|RHEA:18073|Reactome:R-HSA-73569 go.json http://purl.obolibrary.org/obo/GO_0004152 GO:0102625 biolink:MolecularActivity cirsimaritin 4'-O-methyltransferase activity Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine = salvigenin + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15530 go.json http://purl.obolibrary.org/obo/GO_0102625 GO:0004151 biolink:MolecularActivity dihydroorotase activity Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+. EC:3.5.2.3|KEGG_REACTION:R01993|MetaCyc:DIHYDROOROT-RXN|RHEA:24296|Reactome:R-HSA-73571 go.json (S)-dihydroorotate amidohydrolase activity|DHOase activity|carbamoylaspartic dehydrase activity|dihydroorotate hydrolase activity http://purl.obolibrary.org/obo/GO_0004151 GO:0102624 biolink:MolecularActivity scutellarein 7-methyl ether 4'-O-methyltransferase activity Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine = ladanein + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15529 go.json http://purl.obolibrary.org/obo/GO_0102624 GO:0102627 biolink:MolecularActivity parthenolide 3beta-hydroxylase activity Catalysis of the reaction: parthenolide + NADPH + O2 + H+ = 3beta-hydroxyparthenolide + NADP + H2O. MetaCyc:RXN-15532 go.json http://purl.obolibrary.org/obo/GO_0102627 GO:0102626 biolink:MolecularActivity parthenolide synthase activity Catalysis of the reaction: costunolide + NADPH + O2 + H+ = parthenolide + NADP(3-) + H2O. MetaCyc:RXN-15531 go.json http://purl.obolibrary.org/obo/GO_0102626 GO:0102629 biolink:MolecularActivity patuletin 3'-O-methyltransferase activity Catalysis of the reaction: patuletin + S-adenosyl-L-methionine = quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+. MetaCyc:RXN-15534 go.json http://purl.obolibrary.org/obo/GO_0102629 GO:0102628 biolink:MolecularActivity costunolide 3beta-hydroxylase activity Catalysis of the reaction: costunolide + NADPH + O2 + H+ = 3beta-hydroxycostunolide + NADP + H2O. MetaCyc:RXN-15533 go.json http://purl.obolibrary.org/obo/GO_0102628 GO:0018799 biolink:MolecularActivity 4-hydroxybenzoate decarboxylase activity Catalysis of the reaction: 4-hydroxybenzoate + H+ = CO2 + phenol. EC:4.1.1.61|KEGG_REACTION:R01238|MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN|RHEA:10876|UM-BBD_reactionID:r0159 go.json 4-hydroxybenzoate carboxy-lyase (phenol-forming)|4-hydroxybenzoate carboxy-lyase activity|p-hydroxybenzoate decarboxylase activity http://purl.obolibrary.org/obo/GO_0018799 GO:0018798 biolink:MolecularActivity gallate decarboxylase activity Catalysis of the reaction: gallate + H+ = CO2 + pyrogallol. EC:4.1.1.59|KEGG_REACTION:R03247|MetaCyc:GALLATE-DECARBOXYLASE-RXN|RHEA:12749|UM-BBD_reactionID:r0005 go.json gallate carboxy-lyase (pyrogallol-forming)|gallate carboxy-lyase activity|gallic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0018798 GO:0018795 biolink:MolecularActivity 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate. UM-BBD_reactionID:r0621 go.json http://purl.obolibrary.org/obo/GO_0018795 GO:0018794 biolink:MolecularActivity 2-hydroxyisobutyrate decarboxylase activity Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol. UM-BBD_reactionID:r0617 go.json http://purl.obolibrary.org/obo/GO_0018794 GO:0018797 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018797 GO:0018796 biolink:MolecularActivity 4,5-dihydroxyphthalate decarboxylase activity Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. EC:4.1.1.55|MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN|RHEA:24184|UM-BBD_enzymeID:e0106 go.json 4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)|4,5-dihydroxyphthalate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0018796 GO:0018791 biolink:MolecularActivity 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate. UM-BBD_reactionID:r0398 go.json http://purl.obolibrary.org/obo/GO_0018791 GO:0018790 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018790 GO:0018793 biolink:MolecularActivity 3,5-dibromo-4-hydroxybenzoate decarboxylase activity Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol. UM-BBD_reactionID:r0546 go.json http://purl.obolibrary.org/obo/GO_0018793 GO:0018792 biolink:MolecularActivity bis(4-chlorophenyl)acetate decarboxylase activity Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM. UM-BBD_reactionID:r0520 go.json DDA decarboxylase activity http://purl.obolibrary.org/obo/GO_0018792 GO:0043731 biolink:MolecularActivity 6-hydroxynicotinate 3-monooxygenase activity Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD. EC:1.14.13.114|MetaCyc:RXN-7573|RHEA:27333 go.json http://purl.obolibrary.org/obo/GO_0043731 GO:0043730 biolink:MolecularActivity 5-ureido-4-imidazole carboxylate hydrolase activity Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2. go.json http://purl.obolibrary.org/obo/GO_0043730 GO:0043737 biolink:MolecularActivity deoxyribonuclease V activity Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate. EC:3.1.21.7|MetaCyc:3.1.21.7-RXN go.json DNase V activity|Escherichia coli endodeoxyribonuclease V activity|endodeoxyribonuclease V|endonuclease V activity http://purl.obolibrary.org/obo/GO_0043737 GO:0043736 biolink:MolecularActivity obsolete DNA-3-methyladenine glycosylase IV activity OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. go.json DNA-3-methyladenine glycosylase IV activity|Mpg II|MpgII True http://purl.obolibrary.org/obo/GO_0043736 GO:0043739 biolink:MolecularActivity G/U mismatch-specific uracil-DNA glycosylase activity Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site. EC:3.2.2.28 go.json GU mismatch-specific uracil-DNA glycosylase activity|MUG|uracil mismatch repair protein http://purl.obolibrary.org/obo/GO_0043739 GO:0043738 biolink:MolecularActivity reduced coenzyme F420 dehydrogenase activity Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420. EC:1.5.98.3|MetaCyc:RXN-8106|RHEA:54752 go.json 1,5-dihydrocoenzyme F420 dehydrogenase activity|F420H2 dehydrogenase activity http://purl.obolibrary.org/obo/GO_0043738 GO:0043733 biolink:MolecularActivity DNA-3-methylbase glycosylase activity Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site. go.json DNA-3-methyladenine glycosylase III|Mag III|MagIII http://purl.obolibrary.org/obo/GO_0043733 GO:0043732 biolink:MolecularActivity 6-hydroxynicotinate dehydrogenase activity Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2. EC:1.17.3.3|KEGG_REACTION:R07221|MetaCyc:RXN-7585|RHEA:22808 go.json 6-hydroxynicotinate hydroxylase activity|6-hydroxynicotinate:O2 oxidoreductase activity|6-hydroxynicotinic acid dehydrogenase activity|6-hydroxynicotinic acid hydroxylase activity http://purl.obolibrary.org/obo/GO_0043732 GO:0043735 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043735 GO:0043734 biolink:MolecularActivity DNA-N1-methyladenine dioxygenase activity Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde. Reactome:R-HSA-112118|Reactome:R-HSA-112123 go.json AlkB|alpha-ketoglutarate-dependent dioxygenase http://purl.obolibrary.org/obo/GO_0043734 GO:0043740 biolink:MolecularActivity GTP cyclohydrolase IIa activity Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H+ + 2 phosphate. EC:3.5.4.29|KEGG_REACTION:R07306|MetaCyc:RXN-10055|RHEA:22468 go.json GTP 8,9-dihydrolase (phosphate-forming)|GTP 8,9-hydrolase (phosphate-forming)|GTP cyclohydrolase III activity http://purl.obolibrary.org/obo/GO_0043740 GO:0043742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043742 GO:0043741 biolink:MolecularActivity alpha-aminoadipate acetyltransferase activity Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A. MetaCyc:RXN-5181 go.json L-2-aminoadipate N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0043741 GO:0043748 biolink:MolecularActivity O-succinylbenzoate synthase activity Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate. EC:4.2.1.113 go.json http://purl.obolibrary.org/obo/GO_0043748 GO:0043747 biolink:MolecularActivity obsolete N2-acetyl-L-lysine deacetylase activity OBSOLETE. Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine. MetaCyc:RXN-5185|RHEA:28598 go.json N-acetyl-lysine deacetylase activity True http://purl.obolibrary.org/obo/GO_0043747 GO:0043749 biolink:MolecularActivity phenol, water dikinase activity Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate. EC:2.7.9.- go.json ATP:phenol:water phosphotransferase activity|phenol:water dikinase activity|phenylphosphate synthase activity http://purl.obolibrary.org/obo/GO_0043749 GO:0043744 biolink:MolecularActivity N2-acetyl-L-aminoadipate kinase activity Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate. MetaCyc:RXN-5182|RHEA:41944 go.json N-acetyl-L-aminoadipate 5-phosphotransferase activity|N-acetylaminoadipate kinase activity|[LysW]-aminoadipate kinase|acetylaminoadipate kinase activity http://purl.obolibrary.org/obo/GO_0043744 GO:0043743 biolink:MolecularActivity LPPG:FO 2-phospho-L-lactate transferase activity Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. EC:2.7.8.28|RHEA:27510 go.json http://purl.obolibrary.org/obo/GO_0043743 GO:0043746 biolink:MolecularActivity obsolete N2-acetyl-L-lysine aminotransferase activity OBSOLETE. Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine. go.json N-acetyl-lysine aminotransferase activity True http://purl.obolibrary.org/obo/GO_0043746 GO:0043745 biolink:MolecularActivity obsolete N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity OBSOLETE. Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate. go.json True http://purl.obolibrary.org/obo/GO_0043745 GO:0043751 biolink:MolecularActivity polyphosphate:AMP phosphotransferase activity Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP. go.json PAP|PPT http://purl.obolibrary.org/obo/GO_0043751 GO:0043750 biolink:MolecularActivity phosphatidylinositol alpha-mannosyltransferase activity Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol. EC:2.4.1.345|MetaCyc:2.4.1.57-RXN|RHEA:47368 go.json GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity|GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity|GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity|GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity|guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity|phosphatidyl-myo-inositol alpha-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0043750 GO:0043753 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043753 GO:0043752 biolink:MolecularActivity adenosylcobinamide kinase activity Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). EC:2.7.1.156|MetaCyc:2.7.1.156-RXN go.json AdoCbi kinase/AdoCbi-phosphate guanylyltransferase|CobU|RTP:adenosylcobinamide phosphotransferase activity|adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase http://purl.obolibrary.org/obo/GO_0043752 GO:0043759 biolink:MolecularActivity methylbutanoate-CoA ligase activity Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA. RHEA:46180 go.json branched chain acyl CoA synthetase (ADP-forming) activity|branched chain acyl-CoA synthetase (ADP-forming) activity|branched-chain acyl CoA synthetase (ADP-forming) activity|branched-chain acyl-CoA synthetase (ADP-forming) activity http://purl.obolibrary.org/obo/GO_0043759 GO:0043758 biolink:MolecularActivity acetate-CoA ligase (ADP-forming) activity Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA. EC:6.2.1.13|MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN|RHEA:15081 go.json acetate thiokinase activity|acetate--CoA ligase (ADP-forming) activity|acetate:CoA ligase (ADP-forming)|acetyl coenzyme A synthetase (adenosine diphosphate-forming)|acetyl-CoA synthetase (ADP-forming) activity|aryl-CoA synthetase (ADP-forming) activity http://purl.obolibrary.org/obo/GO_0043758 GO:0043755 biolink:MolecularActivity alpha-ribazole phosphatase activity Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate. EC:3.1.3.73|KEGG_REACTION:R04594|MetaCyc:RXN-16788|RHEA:24456 go.json CobC|alpha-ribazole-5'-P phosphatase activity|alpha-ribazole-5'-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0043755 GO:0043754 biolink:MolecularActivity dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine. EC:2.3.1.168|MetaCyc:2.3.1.168-RXN|RHEA:18865 go.json 2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity|2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity|dihydrolipoamide branched chain acyltransferase activity|dihydrolipoamide branched chain transacylase activity|dihydrolipoyl transacylase activity|enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity http://purl.obolibrary.org/obo/GO_0043754 GO:0043757 biolink:MolecularActivity adenosylcobinamide-phosphate synthase activity Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide. EC:6.3.1.10|MetaCyc:RXN-6261|RHEA:21896 go.json AdoCbi-P synthase activity|CbiB|adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0043757 GO:0043756 biolink:MolecularActivity adenosylcobinamide hydrolase activity Catalysis of the reaction: adenosylcobinamide + H2O = (R)-1-aminopropan-2-ol + adenosylcobyrate. EC:3.5.1.90|KEGG_REACTION:R05226|MetaCyc:R346-RXN|RHEA:23504 go.json AdoCbi amidohydrolase activity|AdoCbi hydrolase activity|CbiZ|adenosylcobinamide amidohydrolase activity http://purl.obolibrary.org/obo/GO_0043756 GO:0043762 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043762 GO:0043761 biolink:MolecularActivity archaetidylserine synthase activity Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP. EC:2.7.8.38 go.json CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity|CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity http://purl.obolibrary.org/obo/GO_0043761 GO:0043764 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043764 GO:0043763 biolink:MolecularActivity UTP:glucose-1-phosphate uridylyltransferase regulator activity Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase. go.json UDP-glucose diphosphorylase regulator activity|UDP-glucose pyrophosphorylase regulator activity|glucose-1-phosphate uridylyltransferase regulator activity http://purl.obolibrary.org/obo/GO_0043763 GO:0043760 biolink:MolecularActivity acetyldiaminopimelate aminotransferase activity Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate. go.json N-acetyl-L,L-diaminopimelate aminotransferase activity|N-acetyl-diaminopimelate aminotransferase activity http://purl.obolibrary.org/obo/GO_0043760 GO:0043769 biolink:CellularComponent Tpg-containing telomere binding complex A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species. go.json telomere complex http://purl.obolibrary.org/obo/GO_0043769 GO:0043766 biolink:MolecularActivity Sep-tRNA:Cys-tRNA synthase activity Catalysis of the reaction: H+ + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate. EC:2.5.1.73|MetaCyc:RXN-10719|RHEA:25686 go.json O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity|Sep-tRNA:Cys-tRNA synthetase activity|SepCysS http://purl.obolibrary.org/obo/GO_0043766 GO:0043765 biolink:MolecularActivity T/G mismatch-specific endonuclease activity Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine. go.json DNA mismatch endonuclease|V.EcoKDcm|Vsr mismatch endonuclease|very short patch repair protein http://purl.obolibrary.org/obo/GO_0043765 GO:0043768 biolink:MolecularActivity S-ribosylhomocysteine lyase activity Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. EC:4.4.1.21|KEGG_REACTION:R01291|MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN|RHEA:17753 go.json LuxS|S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]|S-ribosylhomocysteinase activity|ribosylhomocysteinase activity http://purl.obolibrary.org/obo/GO_0043768 GO:0043767 biolink:MolecularActivity pyrrolysyl-tRNA synthetase activity Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl). EC:6.1.1.26|MetaCyc:6.1.1.26-RXN|RHEA:19277 go.json PylRS|pyrrolysine-tRNA ligase activity http://purl.obolibrary.org/obo/GO_0043767 GO:0102670 biolink:MolecularActivity 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine. EC:2.1.1.212|MetaCyc:RXN-3624|RHEA:31371 go.json http://purl.obolibrary.org/obo/GO_0102670 GO:0102672 biolink:MolecularActivity fatty acid alpha-oxygenase activity Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid = a 2(R)-hydroperoxy fatty acid. MetaCyc:RXN-4121 go.json http://purl.obolibrary.org/obo/GO_0102672 GO:0102671 biolink:MolecularActivity 6a-hydroxymaackiain-3-O-methyltransferase activity Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = H+ + (+)-pisatin + S-adenosyl-L-homocysteine. EC:2.1.1.270|MetaCyc:RXN-4002|RHEA:35471 go.json http://purl.obolibrary.org/obo/GO_0102671 GO:0102674 biolink:MolecularActivity obsolete C4-demethylase activity OBSOLETE. Catalysis of the reaction: 24-methylenelophenol + a demethylated methyl acceptor = 9xi-episterol + a methylated methyl acceptor. MetaCyc:RXN-4181 go.json True http://purl.obolibrary.org/obo/GO_0102674 GO:0043773 biolink:MolecularActivity coenzyme F420-0 gamma-glutamyl ligase activity Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. go.json F420-0 gamma-glutamyl ligase activity http://purl.obolibrary.org/obo/GO_0043773 GO:0102673 biolink:MolecularActivity fatty aldehyde dehydrogenase activity Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde = NADH(2-) + 2 H+ + a fatty acid. MetaCyc:RXN-4142 go.json http://purl.obolibrary.org/obo/GO_0102673 GO:0043772 biolink:MolecularActivity acyl-phosphate glycerol-3-phosphate acyltransferase activity Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate. go.json acyl-phosphate:glycerol-3-phosphate acyltransferase activity|acylphosphate glycerol-3-phosphate acyltransferase activity|acylphosphate:glycerol-3-phosphate acyltransferase activity http://purl.obolibrary.org/obo/GO_0043772 GO:0102676 biolink:MolecularActivity avenasterol-desaturase activity Catalysis of the reaction: avenasterol + O2 + NADPH + H+ = 5-dehydroavenasterol + 2 H2O + NADP. MetaCyc:RXN-4209 go.json http://purl.obolibrary.org/obo/GO_0102676 GO:0043775 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043775 GO:0102675 biolink:MolecularActivity obsolete C4-methyltransferase activity OBSOLETE. Catalysis of the reaction: 24-ethylidenelophenol + a demethylated methyl acceptor = avenasterol + a methylated methyl acceptor. MetaCyc:RXN-4208 go.json True http://purl.obolibrary.org/obo/GO_0102675 GO:0043774 biolink:MolecularActivity coenzyme F420-2 alpha-glutamyl ligase activity Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate. EC:6.3.2.32|RHEA:42332 go.json F420-2 alpha-glutamyl ligase activity http://purl.obolibrary.org/obo/GO_0043774 GO:0102678 biolink:MolecularActivity 22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP = H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH. MetaCyc:RXN-4229 go.json http://purl.obolibrary.org/obo/GO_0102678 GO:0102677 biolink:MolecularActivity campesterol,NADPH:oxygen oxidoreductase activity Catalysis of the reaction: H+ + campesterol + O2 + NADPH = (22S)-22-hydroxycampesterol + H2O + NADP. MetaCyc:RXN-4225 go.json http://purl.obolibrary.org/obo/GO_0102677 GO:0043771 biolink:MolecularActivity cytidine kinase activity Catalysis of the reaction: ATP + cytidine = ADP + CMP. EC:2.7.1.213|RHEA:24674 go.json uridine-cytidine kinase activity http://purl.obolibrary.org/obo/GO_0043771 GO:0043770 biolink:MolecularActivity demethylmenaquinone methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine. EC:2.1.1.163 go.json http://purl.obolibrary.org/obo/GO_0043770 GO:0102679 biolink:MolecularActivity (5alpha)-campestan-3-one hydroxylase activity Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH = (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP. MetaCyc:RXN-4230 go.json http://purl.obolibrary.org/obo/GO_0102679 GO:0043777 biolink:MolecularActivity cobalt-precorrin-7 C15-methyltransferase activity Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2. MetaCyc:RXN-8767|RHEA:34591 go.json cobalt-precorrin 7 C15-methyltransferase activity|precorrin-6 methyltransferase|precorrin-6Y C5,15-methyltransferase (decarboxylating)|precorrin-6Y methylase http://purl.obolibrary.org/obo/GO_0043777 GO:0043776 biolink:MolecularActivity cobalt-precorrin-6B C5-methyltransferase activity Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7. MetaCyc:RXN-8766|RHEA:36067 go.json cobalt-precorrin 6B C5-methyltransferase activity|precorrin-6 methyltransferase activity|precorrin-6Y C5,15-methyltransferase (decarboxylating)|precorrin-6Y methylase http://purl.obolibrary.org/obo/GO_0043776 GO:0043779 biolink:MolecularActivity cobalt-precorrin-5A acetaldehyde-lyase activity Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+. EC:3.7.1.12|MetaCyc:RXN-8763|RHEA:26281 go.json cobalt-precorrin 5A acetaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0043779 GO:0043778 biolink:MolecularActivity cobalt-precorrin-8 methylmutase activity Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate. EC:5.4.99.60|MetaCyc:RXN-8768|RHEA:16209 go.json cobalt-precorrin 8 methylmutase activity|cobalt-precorrin 8X methylmutase activity|cobalt-precorrin-8X methylmutase activity http://purl.obolibrary.org/obo/GO_0043778 GO:0102681 biolink:MolecularActivity isoamylase (maltodextrin-releasing) activity Catalysis of the reaction: n H2O + a glycogen = n a maltodextrin. MetaCyc:RXN-4301 go.json http://purl.obolibrary.org/obo/GO_0102681 GO:0102680 biolink:MolecularActivity campest-4-en-3-one hydroxylase activity Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH = (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP. MetaCyc:RXN-4231 go.json http://purl.obolibrary.org/obo/GO_0102680 GO:0102682 biolink:MolecularActivity N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate. MetaCyc:RXN-4313|RHEA:48560 go.json http://purl.obolibrary.org/obo/GO_0102682 GO:0102685 biolink:MolecularActivity UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin = H+ + trans-zeatin-7-N-glucoside + UDP. MetaCyc:RXN-4721 go.json http://purl.obolibrary.org/obo/GO_0102685 GO:0043784 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043784 GO:0102684 biolink:MolecularActivity L-phenylalanine N-monooxygenase activity Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ = (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide. EC:1.14.14.40|MetaCyc:RXN-4602|RHEA:33263 go.json http://purl.obolibrary.org/obo/GO_0102684 GO:0043783 biolink:MolecularActivity oxidoreductase activity, acting on metal ions, flavin as acceptor Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor. EC:1.16.8.- go.json oxidoreductase activity, oxidizing metal ions with flavin as acceptor|oxidoreductase activity, reducing metal ions, flavin as acceptor http://purl.obolibrary.org/obo/GO_0043783 GO:0043786 biolink:MolecularActivity cinnamate reductase activity Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+. go.json http://purl.obolibrary.org/obo/GO_0043786 GO:0102687 biolink:MolecularActivity UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + dihydrozeatin-7-N-glucose + UDP. MetaCyc:RXN-4724 go.json http://purl.obolibrary.org/obo/GO_0102687 GO:0102686 biolink:MolecularActivity UDP-glucose:trans-zeatin 9-N-glucosyltransferase Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin = H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-). MetaCyc:RXN-4722 go.json http://purl.obolibrary.org/obo/GO_0102686 GO:0043785 biolink:MolecularActivity cinnamoyl-CoA:phenyllactate CoA-transferase activity Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate. EC:2.8.3.17|KEGG_REACTION:R07796|MetaCyc:2.8.3.17-RXN|RHEA:15601 go.json (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity|FldA http://purl.obolibrary.org/obo/GO_0043785 GO:0102689 biolink:MolecularActivity UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP. MetaCyc:RXN-4727 go.json http://purl.obolibrary.org/obo/GO_0102689 GO:0043780 biolink:MolecularActivity cobalt-precorrin-5B C1-methyltransferase activity Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A. MetaCyc:RXN-8764|RHEA:26285 go.json cobalt-precorrin 5B C1-methyltransferase activity http://purl.obolibrary.org/obo/GO_0043780 GO:0102688 biolink:MolecularActivity dihydrozeatin UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP. MetaCyc:RXN-4725 go.json http://purl.obolibrary.org/obo/GO_0102688 GO:0043782 biolink:MolecularActivity cobalt-precorrin-3 C17-methyltransferase activity Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine. MetaCyc:RXN-8761|RHEA:26273 go.json cobalt-precorrin 3 C17-methyltransferase activity|cobalt-precorrin-3 methylase|cobalt-precorrin-3 methyltransferase|cobalt-precorrin-3B C17-methyltransferase activity http://purl.obolibrary.org/obo/GO_0043782 GO:0043781 biolink:MolecularActivity cobalt-factor II C20-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III. EC:2.1.1.151|MetaCyc:RXN-8760|RHEA:17997 go.json CbiL|S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity|cobalt-factor II C20 methyltransferase activity|cobalt-precorrin-2 C(20)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0043781 GO:0043788 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043788 GO:0043787 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043787 GO:0043789 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043789 GO:0102690 biolink:MolecularActivity isopentenyladenine UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP. MetaCyc:RXN-4728 go.json http://purl.obolibrary.org/obo/GO_0102690 GO:0102692 biolink:MolecularActivity benzyladenine UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP. MetaCyc:RXN-4730 go.json http://purl.obolibrary.org/obo/GO_0102692 GO:0102691 biolink:MolecularActivity UDP-glucose:benzyladenine 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + benzyladenine-7-N-glucoside + UDP. MetaCyc:RXN-4729 go.json http://purl.obolibrary.org/obo/GO_0102691 GO:0102694 biolink:MolecularActivity kinetin UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kinetin = H+ + 9-(alpha-D-glucosyl)kinetin + UDP. MetaCyc:RXN-4732 go.json http://purl.obolibrary.org/obo/GO_0102694 GO:0102693 biolink:MolecularActivity UDP-glucose:kinetin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kinetin = H+ + kinetin-7-N-glucoside + UDP. MetaCyc:RXN-4731 go.json http://purl.obolibrary.org/obo/GO_0102693 GO:0102696 biolink:MolecularActivity cis-zeatin UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP. MetaCyc:RXN-4734 go.json http://purl.obolibrary.org/obo/GO_0102696 GO:0043795 biolink:MolecularActivity glyceraldehyde oxidoreductase activity Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+. EC:1.2.99.8|RHEA:36047 go.json http://purl.obolibrary.org/obo/GO_0043795 GO:0043794 biolink:MolecularActivity formate dehydrogenase (coenzyme F420) activity Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420. EC:1.2.99.- go.json formate dehydrogenase (F420) activity http://purl.obolibrary.org/obo/GO_0043794 GO:0102695 biolink:MolecularActivity UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + cis-zeatin-7-N-glucoside + UDP. MetaCyc:RXN-4733 go.json http://purl.obolibrary.org/obo/GO_0102695 GO:0102698 biolink:MolecularActivity 5-epi-aristolochene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphoric acid. EC:4.2.3.61|MetaCyc:RXN-4781|RHEA:28635 go.json http://purl.obolibrary.org/obo/GO_0102698 GO:0043797 biolink:MolecularActivity glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin. EC:1.2.7.6|MetaCyc:1.2.7.6-RXN|RHEA:24148 go.json D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity|GAPOR|glyceraldehyde-3-phosphate Fd oxidoreductase activity|glyceraldehyde-3-phosphate ferredoxin reductase activity http://purl.obolibrary.org/obo/GO_0043797 GO:0043796 biolink:MolecularActivity glyceraldehyde dehydrogenase (NADP) activity Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+. EC:1.2.1.89|RHEA:40163 go.json http://purl.obolibrary.org/obo/GO_0043796 GO:0102697 biolink:MolecularActivity trans-zeatin-O-glucoside UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP. MetaCyc:RXN-4736 go.json http://purl.obolibrary.org/obo/GO_0102697 GO:0043791 biolink:MolecularActivity dimethylamine methyltransferase activity Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine. EC:2.1.1.249|MetaCyc:RXN-8100|RHEA:41175 go.json DMA methyltransferase 1|DMAMT 1|MT1|dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity|dimethylamine:corrinoid methyltransferase activity|mtbB1 http://purl.obolibrary.org/obo/GO_0043791 GO:0043790 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043790 GO:0102699 biolink:MolecularActivity 2-methylpropionitrile hydroxylase activity Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH = 2-hydroxy-2-methylpropanenitrile + NADP + H2O. MetaCyc:RXN-5082|RHEA:51964 go.json http://purl.obolibrary.org/obo/GO_0102699 GO:0043793 biolink:MolecularActivity beta-ribofuranosylaminobenzene 5'-phosphate synthase activity Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate. MetaCyc:RXN-8124 go.json beta-RFAP synthase activity http://purl.obolibrary.org/obo/GO_0043793 GO:0043792 biolink:MolecularActivity enamidase activity Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4. EC:3.5.2.18|KEGG_REACTION:R07984|MetaCyc:3.5.2.18-RXN|RHEA:17209 go.json 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0043792 GO:0043799 biolink:MolecularActivity glycine oxidase activity Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide. EC:1.4.3.19|MetaCyc:1.4.3.19-RXN|MetaCyc:RXN-8672|MetaCyc:RXN-8673|MetaCyc:RXN-8674 go.json glycine:oxygen oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0043799 GO:0043798 biolink:MolecularActivity glycerate 2-kinase activity Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP. EC:2.7.1.165|MetaCyc:GKI-RXN|RHEA:27377 go.json D-glycerate 2-kinase activity|glycerate kinase http://purl.obolibrary.org/obo/GO_0043798 GO:0043704 biolink:BiologicalProcess photoreceptor cell fate specification The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0043704 GO:0043703 biolink:BiologicalProcess photoreceptor cell fate determination The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0043703 GO:0043706 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043706 GO:0043705 biolink:BiologicalProcess cyanophycin metabolic process The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups. go.json cyanophycin metabolism|multi-L-arginyl-poly(L-aspartic acid) metabolism http://purl.obolibrary.org/obo/GO_0043705 GO:0043700 biolink:CellularComponent pterinosome A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance. go.json http://purl.obolibrary.org/obo/GO_0043700 GO:0043702 biolink:CellularComponent carotenoid vesicle A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance. go.json http://purl.obolibrary.org/obo/GO_0043702 GO:0043701 biolink:CellularComponent cyanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance. go.json http://purl.obolibrary.org/obo/GO_0043701 GO:0043708 biolink:BiologicalProcess cell adhesion involved in biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. go.json cell adhesion during biofilm formation http://purl.obolibrary.org/obo/GO_0043708 GO:0043707 biolink:BiologicalProcess cell adhesion involved in single-species biofilm formation in or on host organism The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species. go.json cell adhesion during single-species biofilm formation in or on host organism http://purl.obolibrary.org/obo/GO_0043707 GO:0043709 biolink:BiologicalProcess cell adhesion involved in single-species biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. go.json cell adhesion during single-species biofilm formation http://purl.obolibrary.org/obo/GO_0043709 GO:0043715 biolink:MolecularActivity 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P. EC:5.3.2.5|MetaCyc:R82-RXN|RHEA:18769 go.json DK-MTP-1-P enolase activity|E-1|MasA|mtnW http://purl.obolibrary.org/obo/GO_0043715 GO:0043714 biolink:MolecularActivity (R)-citramalate synthase activity Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA. EC:2.3.3.21|MetaCyc:RXN-7743|RHEA:19045 go.json citramalate synthase http://purl.obolibrary.org/obo/GO_0043714 GO:0043717 biolink:MolecularActivity 2-hydroxyglutaryl-CoA dehydratase activity Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA. MetaCyc:RXN-1083|RHEA:42448 go.json (R)-2-hydroxyglutaryl-CoA dehydratase activity http://purl.obolibrary.org/obo/GO_0043717 GO:0043716 biolink:MolecularActivity 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene. KEGG_REACTION:R07394|MetaCyc:R83-RXN|RHEA:14481 go.json 2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity|HK-MTPenyl-1-P phosphatase activity http://purl.obolibrary.org/obo/GO_0043716 GO:0043711 biolink:BiologicalProcess pilus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. go.json pilus organisation|pilus organization and biogenesis http://purl.obolibrary.org/obo/GO_0043711 gocheck_do_not_annotate GO:0043710 biolink:BiologicalProcess cell adhesion involved in multi-species biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species. go.json cell adhesion during multi-species biofilm formation http://purl.obolibrary.org/obo/GO_0043710 GO:0043713 biolink:MolecularActivity (R)-2-hydroxyisocaproate dehydrogenase activity Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+. go.json http://purl.obolibrary.org/obo/GO_0043713 GO:0043712 biolink:MolecularActivity 2-hydroxyisocaproate CoA-transferase activity Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate. go.json (R)-2-hydroxyisocaproate CoA transferase activity|(R)-2-hydroxyisocaproate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0043712 GO:0043719 biolink:MolecularActivity 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O. EC:1.14.13.-|MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN go.json http://purl.obolibrary.org/obo/GO_0043719 GO:0043718 biolink:MolecularActivity 2-hydroxymethylglutarate dehydrogenase activity Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD+ = 2-formylglutarate + H+ + NADH. EC:1.1.1.291|KEGG_REACTION:R07985|MetaCyc:1.1.1.291-RXN|RHEA:15505|Wikipedia:2-hydroxymethylglutarate_dehydrogenase go.json (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity|HgD http://purl.obolibrary.org/obo/GO_0043718 GO:0043720 biolink:MolecularActivity 3-keto-5-aminohexanoate cleavage activity Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate. MetaCyc:R125-RXN|RHEA:31555 go.json 3-keto-5-aminohexanoate cleavage enzyme http://purl.obolibrary.org/obo/GO_0043720 GO:0043726 biolink:MolecularActivity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate. MetaCyc:RIBOPHOSPHAT-RXN|RHEA:25197 go.json pyrimidine phosphatase activity http://purl.obolibrary.org/obo/GO_0043726 GO:0043725 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043725 GO:0043728 biolink:MolecularActivity 2-keto-4-methylthiobutyrate aminotransferase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine. EC:4.1.1.- go.json http://purl.obolibrary.org/obo/GO_0043728 GO:0043727 biolink:MolecularActivity 5-amino-4-imidazole carboxylate lyase activity Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate. EC:4.1.1.21 go.json http://purl.obolibrary.org/obo/GO_0043727 GO:0043722 biolink:MolecularActivity 4-hydroxyphenylacetate decarboxylase activity Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2. EC:4.1.1.83|KEGG_REACTION:R07312|MetaCyc:4.1.1.83-RXN|RHEA:22732 go.json 4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)|4-Hpd activity|4-hydroxyphenylacetate carboxy-lyase activity|p-Hpd activity|p-hydroxyphenylacetate decarboxylase activity http://purl.obolibrary.org/obo/GO_0043722 GO:0043721 biolink:MolecularActivity 4-hydroxybutanoyl-CoA dehydratase activity Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O. EC:4.2.1.120|KEGG_REACTION:R05337|MetaCyc:RXN-8890|RHEA:26530 go.json 4-hydroxybutanoyl-CoA hydro-lyase|4-hydroxybutyryl-CoA dehydratase activity|gamma-hydroxybutanoyl-CoA dehydratase activity|gamma-hydroxybutyryl-CoA dehydratase activity http://purl.obolibrary.org/obo/GO_0043721 GO:0043724 biolink:MolecularActivity 2-keto-3-deoxygalactonate aldolase activity Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate. go.json KDGal aldolase activity http://purl.obolibrary.org/obo/GO_0043724 GO:0043723 biolink:MolecularActivity 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia. MetaCyc:RXN-10058 go.json 2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity|DRAP deaminase activity http://purl.obolibrary.org/obo/GO_0043723 GO:0043729 biolink:MolecularActivity 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+. EC:3.5.1.102|RHEA:27282 go.json http://purl.obolibrary.org/obo/GO_0043729 GO:0004129 biolink:MolecularActivity cytochrome-c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. EC:7.1.1.9|MetaCyc:CYTOCHROME-C-OXIDASE-RXN|RHEA:11436|Reactome:R-HSA-163214 go.json Warburg's respiratory enzyme activity|aa3-type cytochrome c oxidase|ba3-type cytochrome c oxidase|caa3-type cytochrome c oxidase|cbb3-type cytochrome c oxidase|complex IV (mitochondrial electron transport) activity|cytochrome a3 activity|cytochrome aa3 activity|cytochrome c oxidase activity|cytochrome oxidase activity|indophenol oxidase|indophenolase http://purl.obolibrary.org/obo/GO_0004129 GO:0004128 biolink:MolecularActivity cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). EC:1.6.2.2|MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN|RHEA:46680|Reactome:R-HSA-198824|Reactome:R-HSA-6806831 go.json NADH 5alpha-reductase activity|NADH-cytochrome b5 reductase activity|NADH-cytochrome-b5 reductase activity|NADH-ferricytochrome b5 oxidoreductase activity|NADH:ferricytochrome-b5 oxidoreductase activity|cytochrome b5 reductase activity|dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity|reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity http://purl.obolibrary.org/obo/GO_0004128 GO:0004125 biolink:MolecularActivity L-seryl-tRNA(Sec) selenium transferase activity Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. EC:2.9.1.1|MetaCyc:2.9.1.1-RXN|RHEA:22728 go.json L-selenocysteinyl-tRNA(Sec) synthase activity|L-selenocysteinyl-tRNA(Sel) synthase activity|L-selenocysteinyl-tRNASec synthase activity|L-selenocysteinyl-tRNASel synthase activity|L-seryl-tRNASec selenium transferase activity|cysteinyl-tRNA(Sec)-selenium transferase activity|cysteinyl-tRNA(Sel)-selenium transferase activity|cysteinyl-tRNA(Ser) selenium transferase activity|cysteinyl-tRNASec-selenium transferase activity|cysteinyl-tRNASel-selenium transferase activity|selenocysteine synthase activity|selenocysteinyl-tRNA(Ser) synthase activity|selenophosphate:L-seryl-tRNASec selenium transferase activity http://purl.obolibrary.org/obo/GO_0004125 GO:0004124 biolink:MolecularActivity cysteine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. EC:2.5.1.47|MetaCyc:ACSERLY-RXN|RHEA:14829 go.json 3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity|O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity|O-acetyl-L-serine sulfhydrylase activity|O-acetyl-L-serine sulfohydrolase activity|O-acetylserine (thiol)-lyase A activity|O-acetylserine (thiol)-lyase activity|O-acetylserine sulfhydrylase activity|O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)|O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity|OAS sulfhydrylase activity|acetylserine sulfhydrylase activity|cysteine synthetase activity http://purl.obolibrary.org/obo/GO_0004124 GO:0004127 biolink:MolecularActivity cytidylate kinase activity Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. EC:2.7.4.14 go.json ATP:CMP phosphotransferase activity|ATP:UMP-CMP phosphotransferase activity|CMP kinase activity|CTP:CMP phosphotransferase activity|UMP-CMP kinase activity|cytidine monophosphate kinase activity|dCMP kinase activity|deoxycytidine monophosphokinase activity|deoxycytidylate kinase activity|pyrimidine nucleoside monophosphate kinase activity http://purl.obolibrary.org/obo/GO_0004127 GO:0004126 biolink:MolecularActivity cytidine deaminase activity Catalysis of the reaction: cytidine + H2O = uridine + NH3. EC:3.5.4.5|MetaCyc:CYTIDEAM2-RXN|RHEA:16069|Reactome:R-HSA-73608|Reactome:R-HSA-83677|Reactome:R-HSA-9817513 go.json cytidine aminohydrolase activity|cytosine nucleoside deaminase activity http://purl.obolibrary.org/obo/GO_0004126 GO:0004121 biolink:MolecularActivity cystathionine beta-lyase activity Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. EC:4.4.1.8|MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN|RHEA:13965 go.json L-cystathionine L-homocysteine-lyase (deaminating)|L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)|beta C-S lyase activity|beta-cystathionase activity|cystathionine L-homocysteine-lyase (deaminating)|cystine lyase activity http://purl.obolibrary.org/obo/GO_0004121 GO:0004120 biolink:MolecularActivity photoreceptor cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide. go.json http://purl.obolibrary.org/obo/GO_0004120 GO:0004123 biolink:MolecularActivity cystathionine gamma-lyase activity Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. EC:4.4.1.1|KEGG_REACTION:R01001|MetaCyc:RXN-15130|RHEA:14005|Reactome:R-HSA-1614583 go.json L-cystathionine cysteine-lyase (deaminating)|L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)|gamma-cystathionase activity|homoserine deaminase activity|homoserine deaminase-cystathionase activity|homoserine dehydratase activity http://purl.obolibrary.org/obo/GO_0004123 GO:0004122 biolink:MolecularActivity cystathionine beta-synthase activity Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. EC:4.2.1.22|MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN|RHEA:10112|Reactome:R-HSA-1614524 go.json L-serine hydro-lyase (adding homocysteine)|L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|beta-thionase activity|methylcysteine synthase activity|serine sulfhydrase activity|serine sulfhydrylase activity http://purl.obolibrary.org/obo/GO_0004122 GO:0018769 biolink:MolecularActivity 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate. UM-BBD_reactionID:r0311 go.json http://purl.obolibrary.org/obo/GO_0018769 GO:0018766 biolink:MolecularActivity dihydrophloroglucinol hydrolase activity Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate. KEGG_REACTION:R07831|MetaCyc:R6-RXN|UM-BBD_reactionID:r0008 go.json http://purl.obolibrary.org/obo/GO_0018766 GO:0018765 biolink:MolecularActivity 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate. MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN|RHEA:59220|UM-BBD_reactionID:r0263 go.json http://purl.obolibrary.org/obo/GO_0018765 GO:0018768 biolink:MolecularActivity 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate. EC:3.7.1.13|UM-BBD_reactionID:r0458 go.json http://purl.obolibrary.org/obo/GO_0018768 GO:0018767 biolink:MolecularActivity 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate. UM-BBD_reactionID:r0399 go.json http://purl.obolibrary.org/obo/GO_0018767 GO:0018762 biolink:MolecularActivity aliphatic nitrilase activity Catalysis of the reaction: R-CN + H2O = R-COOH + NH3. EC:3.5.5.7|MetaCyc:3.5.5.7-RXN|RHEA:46188|UM-BBD_reactionID:r0622 go.json aliphatic nitrile aminohydrolase activity http://purl.obolibrary.org/obo/GO_0018762 GO:0018761 biolink:MolecularActivity bromoxynil nitrilase activity Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4. Involved in the bacterial degradation of the herbicide bromoxynil. EC:3.5.5.6|KEGG_REACTION:R04349|MetaCyc:3.5.5.6-RXN|RHEA:22100|UM-BBD_enzymeID:e0357 go.json 3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity|bromoxynil-specific nitrilase activity http://purl.obolibrary.org/obo/GO_0018761 GO:0018764 biolink:MolecularActivity N-isopropylammelide isopropylaminohydrolase activity Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine. EC:3.5.4.42|MetaCyc:R123-RXN|RHEA:23608|UM-BBD_enzymeID:e0086 go.json AtzC http://purl.obolibrary.org/obo/GO_0018764 GO:0018763 biolink:MolecularActivity hydroxydechloroatrazine ethylaminohydrolase activity Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine. EC:3.5.4.43|MetaCyc:R122-RXN|RHEA:23092|UM-BBD_enzymeID:e0085 go.json 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity|AtzB|hydroxyatrazine ethylaminohydrolase activity|hydroxyatrazine hydrolase activity http://purl.obolibrary.org/obo/GO_0018763 GO:0018760 biolink:MolecularActivity thiocyanate hydrolase activity Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4. EC:3.5.5.8|KEGG_REACTION:R05780|MetaCyc:RXN-1761|RHEA:21464|UM-BBD_reactionID:r0598 go.json thiocyanate aminohydrolase activity http://purl.obolibrary.org/obo/GO_0018760 GO:0004139 biolink:MolecularActivity deoxyribose-phosphate aldolase activity Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. EC:4.1.2.4|KEGG_REACTION:R01066|MetaCyc:DEOXYRIBOSE-P-ALD-RXN|RHEA:12821|Reactome:R-HSA-6787321 go.json 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)|2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity|2-deoxyribose-5-phosphate aldolase activity|deoxyriboaldolase activity|deoxyribose-5-phosphate aldolase activity|phosphodeoxyriboaldolase activity http://purl.obolibrary.org/obo/GO_0004139 GO:0004136 biolink:MolecularActivity deoxyadenosine kinase activity Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+. EC:2.7.1.76|KEGG_REACTION:R02089|MetaCyc:DEOXYADENOSINE-KINASE-RXN|RHEA:23452 go.json ATP:deoxyadenosine 5'-phosphotransferase activity|deoxyadenosine kinase (phosphorylating)|purine-deoxyribonucleoside kinase activity http://purl.obolibrary.org/obo/GO_0004136 GO:0004135 biolink:MolecularActivity amylo-alpha-1,6-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. EC:3.2.1.33|MetaCyc:3.2.1.33-RXN|Reactome:R-HSA-71593 go.json amylo-1,6-glucosidase activity|amylopectin 1,6-glucosidase activity|dextrin 6-alpha-D-glucosidase activity|dextrin-1,6-glucosidase activity|glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity http://purl.obolibrary.org/obo/GO_0004135 GO:0004138 biolink:MolecularActivity deoxyguanosine kinase activity Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+. EC:2.7.1.113|KEGG_REACTION:R01967|MetaCyc:DEOXYGUANOSINE-KINASE-RXN|RHEA:19201 go.json (dihydroxypropoxymethyl)guanine kinase activity|2'-deoxyguanosine kinase activity|ATP:deoxyguanosine 5'-phosphotransferase activity|NTP-deoxyguanosine 5'-phosphotransferase activity|deoxyguanosine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0004138 GO:0004137 biolink:MolecularActivity deoxycytidine kinase activity Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. EC:2.7.1.74|MetaCyc:DEOXYCYTIDINE-KINASE-RXN|RHEA:20061 go.json 2'-deoxycytidine kinase activity|Ara-C kinase activity|NTP:deoxycytidine 5'-phosphotransferase activity|arabinofuranosylcytosine kinase activity|deoxycytidine kinase (phosphorylating)|deoxycytidine-cytidine kinase activity http://purl.obolibrary.org/obo/GO_0004137 GO:0004132 biolink:MolecularActivity dCMP deaminase activity Catalysis of the reaction: dCMP + H2O = dUMP + NH3. EC:3.5.4.12|MetaCyc:DCMP-DEAMINASE-RXN|RHEA:22924|Reactome:R-HSA-73596 go.json dCMP aminohydrolase activity|deoxy-CMP-deaminase activity|deoxycytidine monophosphate deaminase activity|deoxycytidine-5'-monophosphate aminohydrolase activity|deoxycytidine-5'-phosphate deaminase activity|deoxycytidylate aminohydrolase activity|deoxycytidylate deaminase activity http://purl.obolibrary.org/obo/GO_0004132 GO:0004131 biolink:MolecularActivity cytosine deaminase activity Catalysis of the reaction: cytosine + H2O = uracil + NH3. EC:3.5.4.1|MetaCyc:CYTDEAM-RXN|RHEA:20605 go.json cytosine aminohydrolase activity|isocytosine deaminase activity http://purl.obolibrary.org/obo/GO_0004131 GO:0004134 biolink:MolecularActivity 4-alpha-glucanotransferase activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. EC:2.4.1.25|MetaCyc:AMYLOMALT-RXN|MetaCyc:RXN-1828|MetaCyc:RXN-9023|Reactome:R-HSA-71552 go.json 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity|D-enzyme activity|amylomaltase activity|debranching enzyme maltodextrin glycosyltransferase activity|dextrin glycosyltransferase activity|dextrin transglycosylase activity|disproportionating enzyme activity|oligo-1,4-1,4-glucantransferase activity http://purl.obolibrary.org/obo/GO_0004134 GO:0004133 biolink:MolecularActivity glycogen debranching enzyme activity Catalysis of the cleavage of branch points in branched glycogen polymers. go.json http://purl.obolibrary.org/obo/GO_0004133 goslim_pir GO:0004130 biolink:MolecularActivity cytochrome-c peroxidase activity Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O. EC:1.11.1.5|MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN|RHEA:16581 go.json apocytochrome c peroxidase activity|cytochrome c peroxidase activity|cytochrome c-551 peroxidase activity|cytochrome c-H2O oxidoreductase activity|cytochrome peroxidase activity|ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity|mesocytochrome c peroxidase azide|mesocytochrome c peroxidase cyanate|mesocytochrome c peroxidase cyanide http://purl.obolibrary.org/obo/GO_0004130 GO:0018777 biolink:MolecularActivity 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol). go.json http://purl.obolibrary.org/obo/GO_0018777 GO:0018776 biolink:MolecularActivity trans-chloroacrylic acid dehalogenase activity Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde. UM-BBD_reactionID:r0689 go.json http://purl.obolibrary.org/obo/GO_0018776 GO:0018779 biolink:MolecularActivity obsolete 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity OBSOLETE. (Was not defined before being made obsolete). go.json 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity True http://purl.obolibrary.org/obo/GO_0018779 GO:0018778 biolink:MolecularActivity DL-2 haloacid dehalogenase activity Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate. EC:3.8.1.10|MetaCyc:RXN-9150|UM-BBD_reactionID:r0382 go.json http://purl.obolibrary.org/obo/GO_0018778 GO:0018773 biolink:MolecularActivity acetylpyruvate hydrolase activity Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. EC:3.7.1.6|KEGG_REACTION:R00324|MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN|RHEA:16097|UM-BBD_reactionID:r0095 go.json 2,4-dioxopentanoate acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0018773 GO:0018772 biolink:MolecularActivity trioxoheptanoate hydrolase activity Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate. MetaCyc:R306-RXN|UM-BBD_reactionID:r0094 go.json http://purl.obolibrary.org/obo/GO_0018772 GO:0018775 biolink:MolecularActivity 2-hydroxymuconate-semialdehyde hydrolase activity Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate. EC:3.7.1.9|MetaCyc:3.7.1.9-RXN|RHEA:14549|UM-BBD_enzymeID:e0139 go.json 2-hydroxymuconate-semialdehyde formylhydrolase activity|2-hydroxymuconic semialdehyde hydrolase activity|HMSH|HOD hydrolase activity http://purl.obolibrary.org/obo/GO_0018775 GO:0018774 biolink:MolecularActivity 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate. EC:3.7.1.8|MetaCyc:3.7.1.8-RXN|RHEA:17161|UM-BBD_enzymeID:e0033 go.json 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity|2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity|HOHPDA hydrolase activity http://purl.obolibrary.org/obo/GO_0018774 GO:0018771 biolink:MolecularActivity 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate. EC:3.7.1.14|MetaCyc:MHPCHYDROL-RXN|RHEA:24789|UM-BBD_reactionID:r0438 go.json (2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity|2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity http://purl.obolibrary.org/obo/GO_0018771 GO:0018770 biolink:MolecularActivity 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+. UM-BBD_reactionID:r0444 go.json http://purl.obolibrary.org/obo/GO_0018770 GO:0004107 biolink:MolecularActivity chorismate synthase activity Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. EC:4.2.3.5|KEGG_REACTION:R01714|MetaCyc:CHORISMATE-SYNTHASE-RXN|RHEA:21020 go.json 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)|5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity|5-enolpyruvylshikimate-3-phosphate phospholyase activity http://purl.obolibrary.org/obo/GO_0004107 GO:0004106 biolink:MolecularActivity chorismate mutase activity Catalysis of the reaction: chorismate = prephenate. EC:5.4.99.5|KEGG_REACTION:R01715|MetaCyc:CHORISMATEMUT-RXN|RHEA:13897 go.json chorismate pyruvatemutase activity|hydroxyphenylpyruvate synthase activity http://purl.obolibrary.org/obo/GO_0004106 GO:0004109 biolink:MolecularActivity coproporphyrinogen oxidase activity Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX. EC:1.3.3.3|KEGG_REACTION:R03220|MetaCyc:RXN0-1461|RHEA:18257|Reactome:R-HSA-189421 go.json coprogen oxidase activity|coproporphyrinogen-III oxidase activity|coproporphyrinogen:oxygen oxidoreductase (decarboxylating)|coproporphyrinogenase activity http://purl.obolibrary.org/obo/GO_0004109 GO:0004108 biolink:MolecularActivity citrate (Si)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. EC:2.3.3.1|MetaCyc:CITSYN-RXN|Reactome:R-HSA-70975 go.json (R)-citric synthase activity|acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]|citrate condensing enzyme activity|citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity|citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)|citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]|citrate oxaloacetate-lyase, CoA-acetylating activity|citrate synthase activity|citrate synthetase activity|citric synthase activity|citric-condensing enzyme activity|citrogenase activity|condensing enzyme activity|oxalacetic transacetase activity|oxaloacetate transacetase activity http://purl.obolibrary.org/obo/GO_0004108 GO:0004103 biolink:MolecularActivity choline kinase activity Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+. EC:2.7.1.32|KEGG_REACTION:R01021|MetaCyc:CHOLINE-KINASE-RXN|RHEA:12837|Reactome:R-HSA-1483004 go.json ATP:choline phosphotransferase activity|choline kinase (phosphorylating)|choline phosphokinase activity|choline-ethanolamine kinase activity http://purl.obolibrary.org/obo/GO_0004103 GO:0004102 biolink:MolecularActivity choline O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. EC:2.3.1.6|KEGG_REACTION:R01023|MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN|RHEA:18821|Reactome:R-HSA-264622 go.json CHOACTase activity|acetyl-CoA:choline O-acetyltransferase activity|choline acetylase activity|choline acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004102 GO:0004105 biolink:MolecularActivity choline-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. EC:2.7.7.15|MetaCyc:2.7.7.15-RXN|RHEA:18997|Reactome:R-HSA-1483081 go.json CDP-choline pyrophosphorylase activity|CDP-choline synthetase activity|CTP-phosphocholine cytidylyltransferase activity|CTP:choline-phosphate cytidylyltransferase activity|CTP:phosphocholine cytidylyltransferase activity|CTP:phosphorylcholine cytidylyltransferase activity|choline phosphate cytidylyltransferase activity|cytidine diphosphocholine pyrophosphorylase activity|phosphocholine cytidylyltransferase activity|phosphorylcholine cytidylyltransferase activity|phosphorylcholine transferase activity|phosphorylcholine:CTP cytidylyltransferase activity http://purl.obolibrary.org/obo/GO_0004105 GO:0004104 biolink:MolecularActivity cholinesterase activity Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. EC:3.1.1.8|MetaCyc:CHOLINESTERASE-RXN|RHEA:21964 go.json BtChoEase activity|acylcholine acylhydrolase activity|anticholineesterase activity|benzoylcholinesterase activity|butyrylcholine esterase activity|butyrylcholinesterase activity|choline esterase II (unspecific) activity|choline esterase activity|non-specific cholinesterase activity|propionylcholinesterase activity|pseudocholinesterase activity http://purl.obolibrary.org/obo/GO_0004104 goslim_chembl GO:0004101 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004101 GO:0004100 biolink:MolecularActivity chitin synthase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1). EC:2.4.1.16|MetaCyc:CHITIN-SYNTHASE-RXN|RHEA:16637 go.json UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity|chitin synthetase activity|chitin-UDP N-acetylglucosaminyltransferase activity|chitin-UDP acetyl-glucosaminyl transferase activity|chitin-uridine diphosphate acetylglucosaminyltransferase activity|trans-N-acetylglucosaminosylase activity http://purl.obolibrary.org/obo/GO_0004100 GO:0018748 biolink:MolecularActivity iprodione amidohydrolase activity Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. UM-BBD_reactionID:r0706 go.json http://purl.obolibrary.org/obo/GO_0018748 GO:0018747 biolink:MolecularActivity phenanthrene-1,2-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene. UM-BBD_reactionID:r0536 go.json http://purl.obolibrary.org/obo/GO_0018747 GO:0018749 biolink:MolecularActivity (3,5-dichlorophenylurea)acetate amidohydrolase activity Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine. UM-BBD_reactionID:r0708 go.json http://purl.obolibrary.org/obo/GO_0018749 GO:0018744 biolink:MolecularActivity limonene-1,2-epoxide hydrolase activity Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. EC:3.3.2.8|MetaCyc:3.3.2.8-RXN|RHEA:10700|UM-BBD_reactionID:r0734 go.json limonene oxide hydrolase activity http://purl.obolibrary.org/obo/GO_0018744 GO:0018743 biolink:MolecularActivity phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene. EC:3.3.2.-|UM-BBD_reactionID:r0560 go.json http://purl.obolibrary.org/obo/GO_0018743 GO:0018746 biolink:MolecularActivity phenanthrene-3,4-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene. UM-BBD_reactionID:r0535 go.json http://purl.obolibrary.org/obo/GO_0018746 GO:0018745 biolink:MolecularActivity epoxide hydrolase A activity Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol. EC:3.3.2.-|UM-BBD_enzymeID:e0049 go.json http://purl.obolibrary.org/obo/GO_0018745 GO:0018740 biolink:MolecularActivity 2'-hydroxybiphenyl-2-sulfinate desulfinase activity Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + sulfite. EC:3.13.1.3|KEGG_REACTION:R07311|MetaCyc:RXN-624|RHEA:12945|UM-BBD_enzymeID:e0216 go.json 2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity|2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity|2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity|2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity|2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity|2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity|2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity|2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity|DszB|HBPSi desulfinase activity|HPBS desulfinase activity|dibenzothiophene desulfurization enzyme B|gene dszB-encoded hydrolase activity http://purl.obolibrary.org/obo/GO_0018740 GO:0018742 biolink:MolecularActivity epoxide hydrolase B activity Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers. EC:3.3.2.-|UM-BBD_enzymeID:e0051 go.json http://purl.obolibrary.org/obo/GO_0018742 GO:0018741 biolink:MolecularActivity linear primary-alkylsulfatase activity Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O =>a primary alcohol + H(+) + sulfate. EC:3.1.6.21|RHEA:67908|UM-BBD_reactionID:r0602 go.json alkyl sulfatase activity http://purl.obolibrary.org/obo/GO_0018741 GO:0004118 biolink:MolecularActivity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. go.json http://purl.obolibrary.org/obo/GO_0004118 GO:0004117 biolink:MolecularActivity calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin. Reactome:R-HSA-111955 go.json calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004117 GO:0004119 biolink:MolecularActivity cGMP-inhibited cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. go.json http://purl.obolibrary.org/obo/GO_0004119 GO:0004114 biolink:MolecularActivity 3',5'-cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. EC:3.1.4.17|MetaCyc:3.1.4.17-RXN|RHEA:14653|Reactome:R-HSA-162425 go.json 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity|3',5' cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity|3',5'-cyclonucleotide phosphodiesterase activity|3',5'-nucleotide phosphodiesterase activity|3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity|3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity|PDE|cyclic 3',5'-mononucleotide phosphodiesterase activity|cyclic 3',5'-nucleotide phosphodiesterase activity|cyclic 3',5'-phosphodiesterase activity|cyclic 3',5-nucleotide monophosphate phosphodiesterase activity|cyclic AMP phosphodiesterase activity|cyclic nucleotide phosphodiesterase activity|cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity|nucleoside 3',5'-cyclic phosphate diesterase activity|nucleoside-3',5-monophosphate phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004114 GO:0004113 biolink:MolecularActivity 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. EC:3.1.4.37|MetaCyc:3.1.4.37-RXN|RHEA:14489 go.json 2',3'-cyclic AMP phosphodiesterase activity|2',3'-cyclic nucleoside monophosphate phosphodiesterase|2',3'-cyclic nucleotide 3'-phosphodiesterase activity|2',3'-cyclic nucleotide 3'-phosphohydrolase activity|2',3'-cyclic nucleotide phosphohydrolase|2':3'-CNMP-3'-ase activity|2':3'-cyclic nucleotide 3'-phosphodiesterase activity|CNPase activity|cyclic 2',3'-nucleotide 3'-phosphodiesterase activity|cyclic 2',3'-nucleotide phosphodiesterase|cyclic-CMP phosphodiesterase activity|nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity http://purl.obolibrary.org/obo/GO_0004113 GO:0004116 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004116 GO:0004115 biolink:MolecularActivity 3',5'-cyclic-AMP phosphodiesterase activity Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. EC:3.1.4.53|MetaCyc:RXN0-5038|RHEA:25277|Reactome:R-HSA-111962|Reactome:R-HSA-418553|Reactome:R-HSA-9629675|Reactome:R-HSA-9644869|Reactome:R-HSA-9705507|Reactome:R-HSA-9708261 go.json 3',5' cAMP-specific phosphodiesterase activity|3',5'-cAMP-specific phosphodiesterase activity|3',5'-cyclic-AMP-specific phosphodiesterase activity|adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity|cAMP-specific phosphodiesterase activity|cyclic AMP-specific phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004115 GO:0004110 biolink:MolecularActivity corticosteroid side-chain-isomerase activity Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al. EC:5.3.1.21|KEGG_REACTION:R04165|MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN|RHEA:17861 go.json 11-deoxycorticosterone aldose-ketose-isomerase activity|11-deoxycorticosterone ketol-isomerase activity http://purl.obolibrary.org/obo/GO_0004110 GO:0004112 biolink:MolecularActivity cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. go.json http://purl.obolibrary.org/obo/GO_0004112 GO:0004111 biolink:MolecularActivity creatine kinase activity Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+. EC:2.7.3.2|KEGG_REACTION:R01881|MetaCyc:CREATINE-KINASE-RXN|RHEA:17157|Reactome:R-HSA-200318|Reactome:R-HSA-200326 go.json ATP:creatine N-phosphotransferase activity|ATP:creatine phosphotransferase activity|BB-CK|CK|CK-BB|CK-MB|CK-MM|CKMiMi|MB-CK|MM-CK|Mi-CK|MiMi-CK|adenosine triphosphate-creatine transphosphorylase activity|creatine phosphokinase activity|creatine phosphotransferase activity|phosphocreatine kinase activity http://purl.obolibrary.org/obo/GO_0004111 GO:0102700 biolink:MolecularActivity alpha-thujene synthase activity Catalysis of the reaction: geranyl diphosphate(3-) = alpha-thujene + diphosphoric acid. MetaCyc:RXN-5105 go.json http://purl.obolibrary.org/obo/GO_0102700 GO:0102702 biolink:MolecularActivity 2-carene synthase activity Catalysis of the reaction: geranyl diphosphate = (+)-2-carene + diphosphoric acid. MetaCyc:RXN-5122 go.json http://purl.obolibrary.org/obo/GO_0102702 GO:0102701 biolink:MolecularActivity tricyclene synthase activity Catalysis of the reaction: geranyl diphosphate(3-) = tricyclene + diphosphoric acid. EC:4.2.3.105|MetaCyc:RXN-5121|RHEA:32687 go.json http://purl.obolibrary.org/obo/GO_0102701 GO:0018759 biolink:MolecularActivity methenyltetrahydromethanopterin cyclohydrolase activity Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H+. EC:3.5.4.27|KEGG_REACTION:R03464|MetaCyc:3.5.4.27-RXN|RHEA:19053|UM-BBD_reactionID:r0347 go.json 5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)|5,10-methenyltetrahydromethanopterin cyclohydrolase activity|N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity|methenyl-H(4)MPT cyclohydrolase activity|methenyl-H4MPT cyclohydrolase activity http://purl.obolibrary.org/obo/GO_0018759 GO:0102704 biolink:MolecularActivity GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol = H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol. EC:2.4.1.257|MetaCyc:RXN-5463|RHEA:29519 go.json http://purl.obolibrary.org/obo/GO_0102704 GO:0102703 biolink:MolecularActivity camphene synthase activity Catalysis of the reaction: geranyl diphosphate = (-)-camphene + diphosphoric acid. EC:4.2.3.117|MetaCyc:RXN-5142|RHEA:25484 go.json http://purl.obolibrary.org/obo/GO_0102703 GO:0018758 biolink:MolecularActivity 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid. UM-BBD_reactionID:r0122 go.json http://purl.obolibrary.org/obo/GO_0018758 GO:0102706 biolink:MolecularActivity butein:oxygen oxidoreductase activity Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+. EC:1.21.3.6|MetaCyc:RXN-6242|RHEA:34203 go.json http://purl.obolibrary.org/obo/GO_0102706 GO:0102705 biolink:MolecularActivity serine decarboxylase activity Catalysis of the reaction: H+ + L-serine = ethanolaminium(1+) + carbon dioxide. MetaCyc:RXN-5641|RHEA:45824 go.json http://purl.obolibrary.org/obo/GO_0102705 GO:0018755 biolink:MolecularActivity 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-. go.json http://purl.obolibrary.org/obo/GO_0018755 GO:0102708 biolink:MolecularActivity S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine. MetaCyc:RXN-6462 go.json http://purl.obolibrary.org/obo/GO_0102708 GO:0018754 biolink:MolecularActivity ammelide aminohydrolase activity Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3. MetaCyc:RXN-8017 go.json http://purl.obolibrary.org/obo/GO_0018754 GO:0102707 biolink:MolecularActivity S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine. EC:2.1.1.49|MetaCyc:RXN-6461 go.json http://purl.obolibrary.org/obo/GO_0102707 GO:0018757 biolink:MolecularActivity deisopropylhydroxyatrazine aminohydrolase activity Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine. KEGG_REACTION:R05574|UM-BBD_reactionID:r0121 go.json http://purl.obolibrary.org/obo/GO_0018757 GO:0018756 biolink:MolecularActivity ammeline aminohydrolase activity Catalysis of the reaction: ammeline + H2O = ammelide + NH3. MetaCyc:RXN-8016|RHEA:26201 go.json http://purl.obolibrary.org/obo/GO_0018756 GO:0102709 biolink:MolecularActivity S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine. MetaCyc:RXN-6464 go.json http://purl.obolibrary.org/obo/GO_0102709 GO:0018751 biolink:MolecularActivity 3,5-dichlorophenylcarboximide hydrolase activity Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate. UM-BBD_reactionID:r0707 go.json http://purl.obolibrary.org/obo/GO_0018751 GO:0018750 biolink:MolecularActivity biuret amidohydrolase activity Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3. EC:3.5.1.84|RHEA:17525|UM-BBD_reactionID:r0846 go.json http://purl.obolibrary.org/obo/GO_0018750 GO:0018753 biolink:MolecularActivity cyanuric acid amidohydrolase activity Catalysis of the reaction: cyanurate + H2O = 1-carboxybiuret + H+. EC:3.5.2.15|MetaCyc:RXN-20062|RHEA:70363|UM-BBD_reactionID:r0116 go.json http://purl.obolibrary.org/obo/GO_0018753 GO:0018752 biolink:MolecularActivity epsilon-caprolactam lactamase activity Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate. MetaCyc:R561-RXN|UM-BBD_reactionID:r0448 go.json http://purl.obolibrary.org/obo/GO_0018752 GO:0018729 biolink:MolecularActivity propionate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA. EC:2.8.3.1|MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN|RHEA:23520|UM-BBD_reactionID:r0087 go.json acetyl-CoA:propanoate CoA-transferase activity|propionate coenzyme A-transferase activity|propionate-CoA:lactoyl-CoA transferase activity|propionyl CoA:acetate CoA transferase activity|propionyl-CoA transferase activity http://purl.obolibrary.org/obo/GO_0018729 GO:0018726 biolink:MolecularActivity 9-phenanthrol sulfotransferase activity Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate. UM-BBD_reactionID:r0564 go.json 9-phenanthrol sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018726 GO:0018725 biolink:MolecularActivity trans-3,4-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate. UM-BBD_reactionID:r0558 go.json trans-3,4-dihydrodiolphenanthrene sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018725 GO:0018728 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018728 GO:0018727 biolink:MolecularActivity 2-phenanthrol sulfotransferase activity Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate. UM-BBD_reactionID:r0563 go.json 2-phenanthrol sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018727 GO:0018722 biolink:MolecularActivity 1-phenanthrol sulfotransferase activity Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate. UM-BBD_reactionID:r0565 go.json 1-phenanthrol sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018722 GO:0018721 biolink:MolecularActivity trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate. UM-BBD_reactionID:r0559 go.json trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018721 GO:0018724 biolink:MolecularActivity 4-phenanthrol sulfotransferase activity Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate. UM-BBD_reactionID:r0562 go.json 4-phenanthrol sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018724 GO:0018723 biolink:MolecularActivity 3-phenanthrol sulfotransferase activity Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate. UM-BBD_reactionID:r0561 go.json 3-phenanthrol sulphotransferase activity http://purl.obolibrary.org/obo/GO_0018723 GO:0018720 biolink:MolecularActivity phenol kinase activity Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate. MetaCyc:PHENOLPHOS-RXN|UM-BBD_reactionID:r0155 go.json http://purl.obolibrary.org/obo/GO_0018720 GO:0018737 biolink:MolecularActivity 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA. UM-BBD_reactionID:r0193 go.json http://purl.obolibrary.org/obo/GO_0018737 GO:0018736 biolink:MolecularActivity 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA. UM-BBD_reactionID:r0206 go.json http://purl.obolibrary.org/obo/GO_0018736 GO:0018739 biolink:MolecularActivity 4-hydroxybenzoyl-CoA thioesterase activity Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H+. EC:3.1.2.23|KEGG_REACTION:R01301|MetaCyc:3.1.2.23-RXN|RHEA:11948|UM-BBD_reactionID:r0141 go.json 4-hydroxybenzoyl-CoA hydrolase activity|4-hydroxybenzoyl-CoA thiolesterase activity http://purl.obolibrary.org/obo/GO_0018739 GO:0018738 biolink:MolecularActivity S-formylglutathione hydrolase activity Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+. EC:3.1.2.12|KEGG_REACTION:R00527|MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN|RHEA:14961|Reactome:R-HSA-5693724|UM-BBD_reactionID:r0241 go.json http://purl.obolibrary.org/obo/GO_0018738 goslim_chembl GO:0018733 biolink:MolecularActivity 3,4-dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. EC:3.1.1.35|UM-BBD_reactionID:r0419 go.json http://purl.obolibrary.org/obo/GO_0018733 GO:0018732 biolink:MolecularActivity sulfolactone hydrolase activity Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate. EC:3.1.1.92|UM-BBD_reactionID:r0583 go.json sulpholactone hydrolase activity http://purl.obolibrary.org/obo/GO_0018732 GO:0018735 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018735 GO:0018734 biolink:MolecularActivity butyrolactone hydrolase activity Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate. UM-BBD_reactionID:r0016 go.json http://purl.obolibrary.org/obo/GO_0018734 GO:0018731 biolink:MolecularActivity 1-oxa-2-oxocycloheptane lactonase activity Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate. UM-BBD_reactionID:r0167 go.json http://purl.obolibrary.org/obo/GO_0018731 GO:0018730 biolink:MolecularActivity glutaconate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA. EC:2.8.3.12|MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN|RHEA:23208|UM-BBD_reactionID:r0085 go.json acetyl-CoA:(E)-glutaconate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0018730 GO:0018708 biolink:MolecularActivity thiol S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether. EC:2.1.1.9|MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN|RHEA:18277|Reactome:R-HSA-175976|UM-BBD_enzymeID:e0146 go.json S-adenosyl-L-methionine:thiol S-methyltransferase activity|TMT|thiol methyltransferase activity http://purl.obolibrary.org/obo/GO_0018708 GO:0018707 biolink:MolecularActivity 1-phenanthrol methyltransferase activity Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene. UM-BBD_reactionID:r0493 go.json http://purl.obolibrary.org/obo/GO_0018707 GO:0018709 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018709 GO:0018704 biolink:MolecularActivity obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity OBSOLETE. Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde. go.json 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity True http://purl.obolibrary.org/obo/GO_0018704 GO:0018703 biolink:MolecularActivity 2,4-dichlorophenoxyacetate dehalogenase activity Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate. UM-BBD_reactionID:r0280 go.json http://purl.obolibrary.org/obo/GO_0018703 GO:0018706 biolink:MolecularActivity pyrogallol hydroxytransferase activity Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene. EC:1.97.1.2|MetaCyc:1.97.1.2-RXN|RHEA:21000|UM-BBD_reactionID:r0006 go.json 1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity|1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)|1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity|1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity|1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity|pyrogallol hydroxyltransferase activity|transhydroxylase activity http://purl.obolibrary.org/obo/GO_0018706 GO:0018705 biolink:MolecularActivity 1,2-dichloroethene reductive dehalogenase activity Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride. UM-BBD_enzymeID:e0272 go.json 1,2-dichloroethylene reductive dehalogenase activity http://purl.obolibrary.org/obo/GO_0018705 GO:0018700 biolink:MolecularActivity 2-chloro-N-isopropylacetanilide reductive dehalogenase activity Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide. EC:1.97.1.-|UM-BBD_reactionID:r0719 go.json http://purl.obolibrary.org/obo/GO_0018700 GO:0018702 biolink:MolecularActivity 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. EC:1.97.1.-|UM-BBD_reactionID:r0440 go.json 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity|DDE dehalogenase activity http://purl.obolibrary.org/obo/GO_0018702 GO:0018701 biolink:MolecularActivity 2,5-dichlorohydroquinone reductive dehalogenase activity Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone). EC:1.97.1.-|UM-BBD_enzymeID:e0366 go.json http://purl.obolibrary.org/obo/GO_0018701 GO:0018719 biolink:MolecularActivity 6-aminohexanoate transaminase activity Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate. MetaCyc:R562-RXN|UM-BBD_reactionID:r0449 go.json http://purl.obolibrary.org/obo/GO_0018719 GO:0018718 biolink:MolecularActivity 1,2-dihydroxy-phenanthrene glycosyltransferase activity Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP. UM-BBD_reactionID:r0569 go.json http://purl.obolibrary.org/obo/GO_0018718 GO:0018715 biolink:MolecularActivity 9-phenanthrol UDP-glucuronosyltransferase activity Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP. UM-BBD_reactionID:r0567 go.json http://purl.obolibrary.org/obo/GO_0018715 GO:0018714 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018714 GO:0018717 biolink:MolecularActivity 9-phenanthrol glycosyltransferase activity Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O. UM-BBD_reactionID:r0511 go.json http://purl.obolibrary.org/obo/GO_0018717 GO:0018716 biolink:MolecularActivity 1-phenanthrol glycosyltransferase activity Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O. UM-BBD_reactionID:r0525 go.json http://purl.obolibrary.org/obo/GO_0018716 GO:0018711 biolink:MolecularActivity benzoyl acetate-CoA thiolase activity Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA. MetaCyc:RXN-2006|UM-BBD_reactionID:r0243 go.json http://purl.obolibrary.org/obo/GO_0018711 GO:0018710 biolink:MolecularActivity acetone carboxylase activity Catalysis of the reaction: acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 4 H+ + 2 phosphate. EC:6.4.1.6|KEGG_REACTION:R05735|MetaCyc:6.4.1.6-RXN|RHEA:18385 go.json acetone:carbon-dioxide ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0018710 GO:0018713 biolink:MolecularActivity 3-ketopimelyl-CoA thiolase activity Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA. MetaCyc:RXN-8032|UM-BBD_reactionID:r0197 go.json http://purl.obolibrary.org/obo/GO_0018713 GO:0018712 biolink:MolecularActivity 3-hydroxybutyryl-CoA thiolase activity Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA. MetaCyc:R7-RXN|UM-BBD_reactionID:r0010 go.json http://purl.obolibrary.org/obo/GO_0018712 GO:0102511 biolink:MolecularActivity pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+. EC:2.4.1.300|MetaCyc:RXN-14440 go.json http://purl.obolibrary.org/obo/GO_0102511 GO:0102510 biolink:MolecularActivity pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+. EC:2.4.1.299|MetaCyc:RXN-14439 go.json http://purl.obolibrary.org/obo/GO_0102510 GO:0102513 biolink:MolecularActivity delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+. MetaCyc:RXN-14442 go.json http://purl.obolibrary.org/obo/GO_0102513 GO:0102512 biolink:MolecularActivity delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+. EC:2.4.1.299|MetaCyc:RXN-14441 go.json http://purl.obolibrary.org/obo/GO_0102512 GO:0102515 biolink:MolecularActivity pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+. MetaCyc:RXN-14447 go.json http://purl.obolibrary.org/obo/GO_0102515 GO:0102514 biolink:MolecularActivity cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+. EC:2.4.1.300|MetaCyc:RXN-14446 go.json http://purl.obolibrary.org/obo/GO_0102514 GO:0102517 biolink:MolecularActivity oleate 12-hydroxylase activity Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O. MetaCyc:RXN-14487 go.json http://purl.obolibrary.org/obo/GO_0102517 GO:0102516 biolink:MolecularActivity delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+. MetaCyc:RXN-14448 go.json http://purl.obolibrary.org/obo/GO_0102516 GO:0102518 biolink:MolecularActivity (11Z)-eicosenoate 14-hydroxylase activity Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O. EC:1.14.18.4|MetaCyc:RXN-14488 go.json http://purl.obolibrary.org/obo/GO_0102518 GO:0102520 biolink:MolecularActivity L-threonine O-3-phosphate phosphatase activity Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate. MetaCyc:RXN-14505 go.json http://purl.obolibrary.org/obo/GO_0102520 GO:0102522 biolink:MolecularActivity tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe = 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe. EC:2.5.1.114|MetaCyc:RXN-14518|RHEA:36355 go.json http://purl.obolibrary.org/obo/GO_0102522 GO:0102521 biolink:MolecularActivity tRNA-4-demethylwyosine synthase activity Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe. EC:4.1.3.44|MetaCyc:RXN-14516|RHEA:36347 go.json http://purl.obolibrary.org/obo/GO_0102521 GO:0102524 biolink:MolecularActivity tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe. EC:1.14.11.42|MetaCyc:RXN-14538|RHEA:37899 go.json tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity http://purl.obolibrary.org/obo/GO_0102524 GO:0102523 biolink:MolecularActivity 2-chloroacrylate reductase activity Catalysis of the reaction: (S)-2-chloropropanoate + NADP = 2-chloroacrylate + NADPH + H+. EC:1.3.1.103|MetaCyc:RXN-14536|RHEA:36591 go.json http://purl.obolibrary.org/obo/GO_0102523 GO:0102526 biolink:MolecularActivity 8-demethylnovobiocic acid C8-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid + H+. EC:2.1.1.284|MetaCyc:RXN-14543|RHEA:36651 go.json http://purl.obolibrary.org/obo/GO_0102526 GO:0102525 biolink:MolecularActivity 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide. EC:1.14.11.41|MetaCyc:RXN-14542|RHEA:36607 go.json http://purl.obolibrary.org/obo/GO_0102525 GO:0102528 biolink:MolecularActivity 7,8,4'-trihydroxyflavone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone = H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone. MetaCyc:RXN-14658 go.json http://purl.obolibrary.org/obo/GO_0102528 GO:0102527 biolink:MolecularActivity 8-demethylnovobiocate synthase activity Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) = H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid. EC:6.3.1.15|MetaCyc:RXN-14547|RHEA:36699 go.json http://purl.obolibrary.org/obo/GO_0102527 GO:0102529 biolink:MolecularActivity apigenin 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate = S-adenosyl-L-homocysteine + genkwanin. MetaCyc:RXN-14661 go.json http://purl.obolibrary.org/obo/GO_0102529 GO:0102531 biolink:MolecularActivity ecdysteroid-phosphate phosphatase activity Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid. MetaCyc:RXN-14734|RHEA:63576 go.json http://purl.obolibrary.org/obo/GO_0102531 GO:0102530 biolink:MolecularActivity aclacinomycin T methylesterase activity Catalysis of the reaction: aclacinomycin T(1+) + H2O = 15-demethylaclacinomycin T + methanol + H+. EC:3.1.1.95|MetaCyc:RXN-14703|RHEA:37891 go.json http://purl.obolibrary.org/obo/GO_0102530 GO:0102533 biolink:MolecularActivity genkwanin 4'-O-methyltransferase activity Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine = H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine. MetaCyc:RXN-14750 go.json http://purl.obolibrary.org/obo/GO_0102533 GO:0102532 biolink:MolecularActivity genkwanin 6-hydroxylase activity Catalysis of the reaction: genkwanin + O2 + NADPH + H+ = scutellarein 7-methyl ether + H2O + NADP. MetaCyc:RXN-14748 go.json http://purl.obolibrary.org/obo/GO_0102532 GO:0102535 biolink:MolecularActivity ladanein 6-O-methyltransferase activity Catalysis of the reaction: ladanein + S-adenosyl-L-methionine = H+ + salvigenin + S-adenosyl-L-homocysteine. MetaCyc:RXN-14752 go.json http://purl.obolibrary.org/obo/GO_0102535 GO:0102534 biolink:MolecularActivity apigenin-7,4'-dimethyl ether 6-hydroxylase activity Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ = ladanein + H2O + NADP. MetaCyc:RXN-14751 go.json http://purl.obolibrary.org/obo/GO_0102534 GO:0102537 biolink:MolecularActivity ecdysone-phosphate phosphatase activity Catalysis of the reaction: ecdysone 22-phosphate + H2O = ecdysone + hydrogenphosphate. MetaCyc:RXN-14766 go.json http://purl.obolibrary.org/obo/GO_0102537 GO:0102536 biolink:MolecularActivity sakuranetin 6-hydroxylase activity Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ = carthamidin-7-methyl ether + H2O + NADP. MetaCyc:RXN-14754 go.json http://purl.obolibrary.org/obo/GO_0102536 GO:0102539 biolink:MolecularActivity UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. MetaCyc:RXN-14769 go.json http://purl.obolibrary.org/obo/GO_0102539 GO:0102538 biolink:MolecularActivity UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. MetaCyc:RXN-14767 go.json http://purl.obolibrary.org/obo/GO_0102538 GO:0102540 biolink:MolecularActivity D-mannose 6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate. MetaCyc:RXN-14815 go.json http://purl.obolibrary.org/obo/GO_0102540 GO:0102542 biolink:MolecularActivity aclacinomycin A methylesterase activity Catalysis of the reaction: aclacinomycin A + H2O = 15-demethoxy-aclacinomycin A + methanol + H+. EC:3.1.1.95|MetaCyc:RXN-14863 go.json http://purl.obolibrary.org/obo/GO_0102542 GO:0102541 biolink:MolecularActivity D-galactose 6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate. MetaCyc:RXN-14816 go.json http://purl.obolibrary.org/obo/GO_0102541 GO:0102544 biolink:MolecularActivity ornaline synthase activity Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ = ornaline + NADP + H2O. MetaCyc:RXN-14880 go.json http://purl.obolibrary.org/obo/GO_0102544 GO:0102543 biolink:MolecularActivity epsilon-rhodomycinone methylesterase activity Catalysis of the reaction: epsilon-rhodomycinone + H2O = 15-demethoxy-epsilon-rhodomycinone + methanol + H+. EC:3.1.1.95|MetaCyc:RXN-14865 go.json http://purl.obolibrary.org/obo/GO_0102543 GO:0102546 biolink:MolecularActivity mannosylglycerate hydrolase activity Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate = alpha-D-mannose + D-glycerate. MetaCyc:RXN-14900|RHEA:58456 go.json http://purl.obolibrary.org/obo/GO_0102546 GO:0102545 biolink:MolecularActivity phosphatidyl phospholipase B activity Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate. EC:3.1.1.5|MetaCyc:RXN-14899 go.json http://purl.obolibrary.org/obo/GO_0102545 GO:0102547 biolink:MolecularActivity glucosylglycerate hydrolase activity Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate = alpha-D-glucose + D-glycerate. MetaCyc:RXN-14901|RHEA:32059 go.json http://purl.obolibrary.org/obo/GO_0102547 GO:0102549 biolink:MolecularActivity 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O = sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+. EC:3.1.1.26|MetaCyc:RXN-14912 go.json http://purl.obolibrary.org/obo/GO_0102549 GO:0004289 biolink:MolecularActivity obsolete subtilase activity OBSOLETE. Was not defined before being made obsolete. go.json subtilase activity True http://purl.obolibrary.org/obo/GO_0004289 GO:0004286 biolink:MolecularActivity obsolete proprotein convertase 2 activity OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond. go.json NEC 2 activity|PC2 activity|neuroendocrine convertase 2 activity|prohormone convertase II activity|proprotein convertase 2 activity True http://purl.obolibrary.org/obo/GO_0004286 GO:0004285 biolink:MolecularActivity obsolete proprotein convertase 1 activity OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond. go.json NEC 1 activity|PC1 activity|neuroendocrine convertase 1 activity|prohormone convertase 3|prohormone convertase I activity|proprotein convertase 1 activity True http://purl.obolibrary.org/obo/GO_0004285 GO:0004287 biolink:MolecularActivity obsolete prolyl oligopeptidase activity OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides. go.json endoprolylpeptidase activity|post-proline cleaving enzyme activity|post-proline endopeptidase activity|proline endopeptidase activity|proline-specific endopeptidase activity|prolyl endopeptidase activity|prolyl oligopeptidase activity True http://purl.obolibrary.org/obo/GO_0004287 GO:0004281 biolink:MolecularActivity obsolete pancreatic elastase II activity OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin. go.json pancreatic elastase 2|pancreatic elastase II activity True http://purl.obolibrary.org/obo/GO_0004281 GO:0004284 biolink:MolecularActivity obsolete acrosin activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa. go.json acrosin activity|acrosin amidase activity|acrosomal protease activity|acrosomal proteinase activity|acrozonase activity|alpha-acrosin|beta-acrosin|psi-acrosin True http://purl.obolibrary.org/obo/GO_0004284 GO:0004283 biolink:MolecularActivity obsolete plasmin activity OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products. go.json actase activity|fibrinase activity|fibrinolysin activity|plasmin activity|serum tryptase activity|thrombolysin True http://purl.obolibrary.org/obo/GO_0004283 GO:0004291 biolink:MolecularActivity obsolete subtilisin activity OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides. go.json ALK-enzyme|SP 266|alcalase 0.6L|alcalase 2.5L|alcalase activity|bacillopeptidase A|bacillopeptidase B|bacillus subtilis alkaline proteinase activity|bacillus subtilis alkaline proteinase bioprase activity|bioprase AL 15|bioprase APL 30|colistinase activity|esperase activity|genenase I|kazusase activity|maxatase activity|opticlean|orientase 10B|protease S|protease VIII|protease XXVII|protin A 3L|savinase 16.0L|savinase 32.0 L EX|savinase 4.0T|savinase 8.0L|savinase activity|subtilisin BL|subtilisin DY|subtilisin E|subtilisin GX|subtilisin J|subtilisin S41|subtilisin activity|subtilisin sendai|subtilopeptidase activity|superase activity|thermoase|thermoase PC 10 True http://purl.obolibrary.org/obo/GO_0004291 GO:0004290 biolink:MolecularActivity obsolete kexin activity OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors. go.json Kex 2p proteinase|Kex2 endopeptidase|Kex2 endoprotease|Kex2 endoproteinase|Kex2 protease|Kex2 proteinase|Kex2-like endoproteinase|Kex2-like precursor protein processing endoprotease|andrenorphin-Gly-generating enzyme|endoproteinase Kex2p|gene KEX2 dibasic proteinase|kexin activity|paired-basic endopeptidase activity|prohormone-processing KEX2 proteinase|prohormone-processing endoprotease activity|prohormone-processing proteinase activity|protease KEX2|proteinase Kex2p|proteinase yscF activity|yeast KEX2 protease activity|yeast cysteine proteinase F True http://purl.obolibrary.org/obo/GO_0004290 GO:0004297 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004297 GO:0004296 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004296 GO:0004299 biolink:MolecularActivity obsolete proteasome endopeptidase activity OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity. go.json multicatalytic endopeptidase|proteasome|proteasome endopeptidase activity|proteasome endopeptidase complex True http://purl.obolibrary.org/obo/GO_0004299 GO:0004298 biolink:MolecularActivity threonine-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. EC:3.4.25.-|Reactome:R-HSA-9818574|Reactome:R-HSA-9818577 go.json 26S protease|MCP|alkaline protease|ingensin|large multicatalytic protease|lens neutral proteinase|multicatalytic endopeptidase complex|multicatalytic proteinase|multicatalytic proteinase (complex)|prosome|proteasome endopeptidase complex|threonine endopeptidase activity|tricorn protease|tricorn proteinase http://purl.obolibrary.org/obo/GO_0004298 GO:0004293 biolink:MolecularActivity obsolete tissue kallikrein activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds. go.json bradykininogenase|callicrein|depot-padutin|dilminal D|glandular kallikrein activity|glumorin|kallidinogenase|kidney kallikrein|kininogenase|kininogenin activity|onokrein P|padreatin|padutin|pancreatic kallikrein|salivary kallikrein|submandibular kallikrein|submaxillary kallikrein|tissue kallikrein activity|urinary kallikrein|urokallikrein True http://purl.obolibrary.org/obo/GO_0004293 GO:0004295 biolink:MolecularActivity obsolete trypsin activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa. go.json alpha-trypsin activity|beta-trypsin activity|cocoonase activity|parenzyme|parenzymol|pseudotrypsin|sperm receptor hydrolase activity|tripcellim|trypsin activity|tryptar|trypure True http://purl.obolibrary.org/obo/GO_0004295 GO:0004294 biolink:MolecularActivity obsolete tripeptidyl-peptidase II activity OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH. go.json TPP|tripeptidyl aminopeptidase II|tripeptidyl aminopeptidase activity|tripeptidyl peptidase II|tripeptidyl peptidase activity|tripeptidyl-peptidase II activity True http://purl.obolibrary.org/obo/GO_0004294 GO:0004263 biolink:MolecularActivity obsolete chymotrypsin activity OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa. go.json alpha-chymar|alpha-chymar ophth|alpha-chymotrypsin A|alpha-chymotrypsin activity|avazyme|chymar|chymotest|chymotrypsin A activity|chymotrypsin B activity|chymotrypsin activity|chymotrypsins A and B|enzeon|quimar|quimotrase activity True http://purl.obolibrary.org/obo/GO_0004263 GO:0004262 biolink:MolecularActivity obsolete cerevisin activity OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides. go.json baker's yeast proteinase B|brewer's yeast proteinase|cerevisin activity|peptidase beta|proteinase yscB activity|yeast proteinase B activity True http://purl.obolibrary.org/obo/GO_0004262 GO:0004261 biolink:MolecularActivity obsolete cathepsin G activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C. go.json cathepsin G activity|chymotrypsin-like proteinase activity|neutral proteinase activity True http://purl.obolibrary.org/obo/GO_0004261 GO:0004279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004279 GO:0004278 biolink:MolecularActivity obsolete granzyme B activity OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa. go.json CCP1 proteinase|CCPII|CTLA1|cytotoxic cell proteinase-1|cytotoxic t-lymphocyte proteinase 2 activity|granzyme B activity|granzyme G|granzyme H True http://purl.obolibrary.org/obo/GO_0004278 GO:0004275 biolink:MolecularActivity obsolete enteropeptidase activity OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen. go.json enterokinase activity|enteropeptidase activity True http://purl.obolibrary.org/obo/GO_0004275 GO:0004274 biolink:MolecularActivity obsolete dipeptidyl-peptidase IV activity OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline. EC:3.4.14.5|MetaCyc:3.4.14.5-RXN go.json DPP IV activity|DPP IV/CD26|Gly-Pro naphthylamidase activity|T cell triggering molecule Tp103|X-PDAP|Xaa-Pro-dipeptidyl-aminopeptidase activity|Xaa-Pro-dipeptidylaminopeptidase activity|amino acyl-prolyl dipeptidyl aminopeptidase activity|dipeptidyl aminopeptidase IV activity|dipeptidyl peptidase IV|dipeptidyl-aminopeptidase IV|dipeptidyl-peptidase IV activity|dipeptidyl-peptide hydrolase activity|glycoprotein GP110|glycylproline aminopeptidase activity|glycylprolyl aminopeptidase activity|glycylprolyl dipeptidylaminopeptidase activity|leukocyte antigen CD26|lymphocyte antigen CD26|pep X|post-proline dipeptidyl aminopeptidase IV activity|postproline dipeptidyl aminopeptidase IV True http://purl.obolibrary.org/obo/GO_0004274 GO:0004277 biolink:MolecularActivity obsolete granzyme A activity OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates. go.json CTLA3|HuTPS|T-cell associated protease 1|T-cell derived serine proteinase|TSP-1|cytotoxic T lymphocyte serine protease|cytotoxic T-lymphocyte proteinase 1 activity|granzyme A activity True http://purl.obolibrary.org/obo/GO_0004277 GO:0102500 biolink:MolecularActivity beta-maltose 4-alpha-glucanotransferase activity Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose. EC:2.4.1.25|MetaCyc:RXN-14354 go.json http://purl.obolibrary.org/obo/GO_0102500 GO:0004276 biolink:MolecularActivity obsolete furin activity OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. go.json PACE|SPC3|dibasic processing enzyme activity|furin activity|paired basic amino acid cleaving enzyme|paired basic amino acid converting enzyme|paired basic amino acid residue cleaving enzyme activity|prohormone convertase activity|serine proteinase PACE True http://purl.obolibrary.org/obo/GO_0004276 GO:0102502 biolink:MolecularActivity ADP-glucose-starch glucosyltransferase activity Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose. EC:2.4.1.242|MetaCyc:RXN-14378 go.json http://purl.obolibrary.org/obo/GO_0102502 GO:0102501 biolink:MolecularActivity D-fructuronate reductase activity Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate. MetaCyc:RXN-14368 go.json http://purl.obolibrary.org/obo/GO_0102501 GO:0102504 biolink:MolecularActivity luteolinidin 5-O-glucosyltransferase activity Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose = luteolinidin 5-O-glucoside + UDP + 2 H+. MetaCyc:RXN-14424 go.json http://purl.obolibrary.org/obo/GO_0102504 GO:0102506 biolink:MolecularActivity cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+. EC:2.4.1.299|MetaCyc:RXN-14432 go.json http://purl.obolibrary.org/obo/GO_0102506 GO:0102505 biolink:MolecularActivity apigeninidin 5-O-glucosyltransferase activity Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose = apigeninidin 5-O-glucoside + UDP + H+. MetaCyc:RXN-14427 go.json http://purl.obolibrary.org/obo/GO_0102505 GO:0004280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004280 GO:0102508 biolink:MolecularActivity cyanidin 3,7-diglucoside glucosidase activity Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O = cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. MetaCyc:RXN-14435 go.json http://purl.obolibrary.org/obo/GO_0102508 GO:0102507 biolink:MolecularActivity cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+. EC:2.4.1.300|MetaCyc:RXN-14434 go.json http://purl.obolibrary.org/obo/GO_0102507 GO:0102509 biolink:MolecularActivity cyanidin 3,5-diglucoside glucosidase activity Catalysis of the reaction: cyanin betaine + H2O = cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. MetaCyc:RXN-14436 go.json http://purl.obolibrary.org/obo/GO_0102509 GO:0102591 biolink:MolecularActivity delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose. MetaCyc:RXN-15352 go.json http://purl.obolibrary.org/obo/GO_0102591 GO:0102590 biolink:MolecularActivity delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+. MetaCyc:RXN-15351 go.json http://purl.obolibrary.org/obo/GO_0102590 GO:0102593 biolink:MolecularActivity UDP-glucose: N-methylanthranilate glucosyltransferase activity Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP. MetaCyc:RXN-15371 go.json http://purl.obolibrary.org/obo/GO_0102593 GO:0102592 biolink:MolecularActivity delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = violdelphin + beta-D-glucose. MetaCyc:RXN-15354 go.json http://purl.obolibrary.org/obo/GO_0102592 GO:0102595 biolink:MolecularActivity cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose. MetaCyc:RXN-15374 go.json http://purl.obolibrary.org/obo/GO_0102595 GO:0102594 biolink:MolecularActivity cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose. MetaCyc:RXN-15372 go.json http://purl.obolibrary.org/obo/GO_0102594 GO:0102597 biolink:MolecularActivity 3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin E + NADP + H2O. EC:1.14.14.122|MetaCyc:RXN-15381|RHEA:41468 go.json http://purl.obolibrary.org/obo/GO_0102597 GO:0043850 biolink:CellularComponent RecFOR complex A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair. go.json http://purl.obolibrary.org/obo/GO_0043850 GO:0102596 biolink:MolecularActivity cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 = ent-sandaracopimaradien-3beta-ol + NADP + H2O. EC:1.14.14.70|MetaCyc:RXN-15379|RHEA:41464 go.json http://purl.obolibrary.org/obo/GO_0102596 GO:0102599 biolink:MolecularActivity cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-beta-amyrin + H2O + NAD(P). MetaCyc:RXN-15383 go.json http://purl.obolibrary.org/obo/GO_0102599 GO:0043852 biolink:MolecularActivity monomethylamine methyltransferase activity Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3. EC:2.1.1.248|MetaCyc:RXN-8098|RHEA:26059 go.json MMAMT|MtmB|monomethylamine:corrinoid methyltransferase activity http://purl.obolibrary.org/obo/GO_0043852 GO:0102598 biolink:MolecularActivity 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin D + NADP + H2O. EC:1.14.14.123|MetaCyc:RXN-15382|RHEA:41472 go.json http://purl.obolibrary.org/obo/GO_0102598 GO:0043851 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043851 GO:0043858 biolink:MolecularActivity arginine:ornithine antiporter activity Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out). RHEA:34991 go.json ArcD|arginine-ornithine antiporter activity|arginine/ornithine antiporter activity http://purl.obolibrary.org/obo/GO_0043858 GO:0043857 biolink:MolecularActivity N-acetylornithine carbamoyltransferase activity Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H+ + phosphate. EC:2.1.3.9|KEGG_REACTION:R07245|MetaCyc:2.1.3.9-RXN|RHEA:18609 go.json AOTC|N-acetylornithine transcarbamylase activity|acetylornithine transcarbamylase activity|carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity|carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity http://purl.obolibrary.org/obo/GO_0043857 GO:0043859 biolink:MolecularActivity obsolete cyanophycinase activity OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides. go.json cyanophycinase activity True http://purl.obolibrary.org/obo/GO_0043859 GO:0043854 biolink:MolecularActivity cyclic nucleotide-gated mechanosensitive monoatomic ion channel activity Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. go.json MscS|cyclic nucleotide gated mechanosensitive ion channel activity|cyclic nucleotide regulated mechanosensitive ion channel|cyclic nucleotide-gated mechanosensitive ion channel activity|cyclic nucleotide-regulated mechanosensitive ion channel|cyclic nucleotide-regulated small mechanosensitive ion channel|small conductance mechanosensitive ion channel http://purl.obolibrary.org/obo/GO_0043854 GO:0043853 biolink:CellularComponent methanol-CoM methyltransferase complex A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol. MetaCyc:CPLX-421 go.json methanol-coenzyme M methyltransferase complex|methanol: CoM methyltransferase complex|methanol: coenzyme M methyltransferase complex|methanol:CoM methyltransferase complex|methanol:coenzyme M methyltransferase complex http://purl.obolibrary.org/obo/GO_0043853 GO:0043856 biolink:MolecularActivity anti-sigma factor antagonist activity The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity. go.json anti-anti-sigma factor activity http://purl.obolibrary.org/obo/GO_0043856 GO:0043855 biolink:MolecularActivity cyclic nucleotide-activated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. go.json cyclic nucleotide activated ion channel activity|cyclic nucleotide gated ion channel activity|cyclic nucleotide-gated ion channel activity|cyclic nucleotide-gated monoatomic ion channel activity http://purl.obolibrary.org/obo/GO_0043855 GO:0043861 biolink:MolecularActivity agmatine:putrescine antiporter activity Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out). go.json agmatine-putrescine antiporter activity|agmatine/putrescine antiporter activity http://purl.obolibrary.org/obo/GO_0043861 GO:0043860 biolink:MolecularActivity cyanophycin synthetase activity Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer). EC:6.3.1.- go.json cphA http://purl.obolibrary.org/obo/GO_0043860 GO:0043863 biolink:MolecularActivity 4-hydroxy-2-ketopimelate aldolase activity Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate. MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN|RHEA:25788 go.json 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity|HHED aldolase activity|HpaI|HpcH http://purl.obolibrary.org/obo/GO_0043863 GO:0043862 biolink:MolecularActivity arginine:agmatine antiporter activity Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out). go.json AdiC|arginine-agmatine antiporter activity|arginine-agmatine exchange transporter activity|arginine/agmatine antiporter activity http://purl.obolibrary.org/obo/GO_0043862 GO:0043869 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043869 GO:0043868 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043868 GO:0043865 biolink:MolecularActivity methionine transmembrane transporter activity Enables the transfer of methionine from one side of a membrane to the other. go.json methionine importer|methionine importer activity|methionine importing activity|methionine-importing activity http://purl.obolibrary.org/obo/GO_0043865 GO:0043864 biolink:MolecularActivity indoleacetamide hydrolase activity Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA. EC:3.5.1.4|MetaCyc:G-5841|RHEA:34371 go.json IAH|IaaH|Tms2|indole acetamide hydrolase activity|indole-3-acetamide hydrolase activity http://purl.obolibrary.org/obo/GO_0043864 GO:0043867 biolink:MolecularActivity 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine. go.json TgtA|archaeal tRNA-guanine transglycosylase activity|archaeosine tRNA-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0043867 GO:0043866 biolink:MolecularActivity adenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin. EC:1.8.4.10|RHEA:21976 go.json AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)|AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)|thioredoxin-dependent 5'-adenylylsulfate reductase activity http://purl.obolibrary.org/obo/GO_0043866 GO:0043872 biolink:MolecularActivity lysine:cadaverine antiporter activity Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out). go.json cadaverine transmembrane transporter activity|cadaverine:lysine antiporter activity|lysine-cadaverine antiporter activity|lysine/cadaverine antiporter activity http://purl.obolibrary.org/obo/GO_0043872 GO:0043871 biolink:MolecularActivity delta1-piperideine-6-carboxylate dehydrogenase activity Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. MetaCyc:RXN-8162|RHEA:49476 go.json AmaB|PIPOX http://purl.obolibrary.org/obo/GO_0043871 GO:0043874 biolink:MolecularActivity acireductone synthase activity Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. EC:3.1.3.77|MetaCyc:3.1.3.77-RXN|RHEA:21700|Reactome:R-HSA-1237129 go.json 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)|E-1|E-1 enolase-phosphatase http://purl.obolibrary.org/obo/GO_0043874 GO:0043873 biolink:MolecularActivity pyruvate-flavodoxin oxidoreductase activity Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin. MetaCyc:PYFLAVOXRE-RXN|RHEA:44140 go.json NifJ|pyruvate:flavodoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043873 GO:0043870 biolink:MolecularActivity N-acetyl-gamma-aminoadipyl-phosphate reductase activity Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. MetaCyc:RXN-5183|RHEA:41948 go.json AGPR|ArgC|LysY|N-acetyl-alpha-glutamyl-phosphate reductase activity|N-acetyl-aminoadipate semialdehyde dehydrogenase activity|NAGSA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0043870 GO:0043879 biolink:MolecularActivity glycolate transmembrane transporter activity Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA). RHEA:29447 go.json glcA|glycolate permease|glycolic acid transmembrane transporter activity|hydroxyacetic acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0043879 GO:0043876 biolink:MolecularActivity D-threonine aldolase activity Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde. EC:4.1.2.42|MetaCyc:4.1.2.42-RXN|RHEA:15257 go.json D-TA|D-allo-TA|D-allo-threonine aldolase activity|DtaAS|low-specificity D-threonine aldolase http://purl.obolibrary.org/obo/GO_0043876 GO:0043875 biolink:MolecularActivity 2-ketobutyrate formate-lyase activity Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate. MetaCyc:KETOBUTFORMLY-RXN|RHEA:28054 go.json KFL|TdcE|keto-acid formate acetyltransferase http://purl.obolibrary.org/obo/GO_0043875 GO:0043878 biolink:MolecularActivity glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+. EC:1.2.1.3|MetaCyc:RXN-3443|RHEA:25294 go.json NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity|glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity|glyceraldehyde-3-phosphate dehydrogenase (NAD) activity|non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD) http://purl.obolibrary.org/obo/GO_0043878 GO:0043877 biolink:MolecularActivity galactosamine-6-phosphate isomerase activity Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3. go.json AgaI|galactosamine-6-phosphate deaminase activity http://purl.obolibrary.org/obo/GO_0043877 GO:0043883 biolink:MolecularActivity malolactic enzyme activity Catalysis of the reaction: malate + H+ = L-lactate + CO2. go.json MleS http://purl.obolibrary.org/obo/GO_0043883 GO:0043882 biolink:MolecularActivity malate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in). go.json Na(+)-malate symporter activity|Na+:malate symporter activity|malate Na(+) symporter activity|malate-sodium symporter activity|malate/sodium cotransporter activity|malate/sodium symporter activity|malate:Na+ symporter activity|malate:sodium cotransporter activity|sodium-dependent malate transporter|sodium/malate symporter activity|sodium:malate symporter activity http://purl.obolibrary.org/obo/GO_0043882 GO:0043885 biolink:MolecularActivity carbon-monoxide dehydrogenase (ferredoxin) activity Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin. EC:1.2.7.4|MetaCyc:1.2.7.4-RXN go.json CO dehydrogenase activity|CO-dehydrogenase (ferredoxin) activity|CO-dehydrogenase activity|CODH|carbon monoxide dehydrogenase (ferredoxin) activity|carbon monoxide dehydrogenase activity|carbon-monoxide dehydrogenase activity|carbon-monoxide,water:ferredoxin oxidoreductase activity|carbon-monoxide:(acceptor) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043885 GO:0043884 biolink:MolecularActivity CO-methylating acetyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA. EC:2.3.1.169|MetaCyc:ACETYLSYNCLTH-RXN|RHEA:45212 go.json ACS|CO-methylating acetyl-coenzyme A synthase activity|acetyl-CoA synthase activity|acetyl-CoA:corrinoid protein O-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0043884 GO:0043881 biolink:MolecularActivity mesaconyl-CoA hydratase activity Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA. go.json beta-methylmalyl-CoA dehydratase activity|mch|mesaconyl-coenzyme A hydratase activity http://purl.obolibrary.org/obo/GO_0043881 GO:0043880 biolink:MolecularActivity crotonyl-CoA reductase activity Catalysis of the reduction of crotonyl-CoA to butyryl-CoA. go.json CCR|crotonyl-coenzyme A reductase activity http://purl.obolibrary.org/obo/GO_0043880 GO:0043887 biolink:MolecularActivity melibiose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in). go.json MelB|Na+ (Li+)/melibiose symporter activity|Na+-melibiose symporter activity|Na+/melibiose symporter activity|Na+:melibiose symporter activity|melibiose carrier protein|melibiose permease|melibiose-Na+ symporter activity|melibiose-sodium symporter activity|melibiose/Na+ symporter activity|melibiose/sodium symporter activity|melibiose:Na+ symporter activity|sodium-melibiose symporter activity|sodium/melibiose symporter activity|sodium:melibiose symporter activity|thiomethylgalactoside permease II http://purl.obolibrary.org/obo/GO_0043887 GO:0043886 biolink:MolecularActivity structural constituent of carboxysome shell The action of a molecule that contributes to the structural integrity of a carboxysome shell, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO2. go.json structural constituent of carboxysome http://purl.obolibrary.org/obo/GO_0043886 GO:0043889 biolink:MolecularActivity (S)-3-O-geranylgeranylglyceryl phosphate synthase activity Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate. go.json (S)-3-O-geranylgeranylglycerylphosphate synthase activity|(S)-GGGP synthase activity|GGGP synthase activity|GGGPS http://purl.obolibrary.org/obo/GO_0043889 GO:0043888 biolink:MolecularActivity (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate. EC:2.5.1.- go.json 2,3-dGGGPS|DGGGP synthase activity|DGGGPS|UbiA http://purl.obolibrary.org/obo/GO_0043888 GO:0102551 biolink:MolecularActivity homogentisate geranylgeranyl transferase activity Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ = diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide. EC:2.5.1.116|MetaCyc:RXN-14929|RHEA:38003 go.json http://purl.obolibrary.org/obo/GO_0102551 GO:0102550 biolink:MolecularActivity 2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+. EC:2.1.1.295|MetaCyc:RXN-14917|RHEA:38007 go.json http://purl.obolibrary.org/obo/GO_0102550 GO:0102553 biolink:MolecularActivity obsolete lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. go.json True http://purl.obolibrary.org/obo/GO_0102553 GO:0043894 biolink:MolecularActivity acetyl-CoA synthetase acetyltransferase activity Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate. go.json Pat|Pat enzyme|protein acetyltransferase activity http://purl.obolibrary.org/obo/GO_0043894 GO:0102552 biolink:MolecularActivity obsolete lipoyl synthase activity (acting on glycine-cleavage complex H protein OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. go.json True http://purl.obolibrary.org/obo/GO_0102552 GO:0043893 biolink:MolecularActivity acetate:monoatomic cation symporter activity Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in). go.json ActP|acetate permease|acetate-cation symporter activity|acetate/cation symporter activity|acetate:cation symporter activity|cation-acetate symporter activity|cation/acetate symporter activity|cation:acetate symporter activity http://purl.obolibrary.org/obo/GO_0043893 GO:0043896 biolink:MolecularActivity glucan 1,6-alpha-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides. EC:3.2.1.70|MetaCyc:3.2.1.70-RXN go.json exo-1,6-alpha-glucosidase activity|exo-1,6-beta-glucosidase|glucan alpha-1,6-D-glucohydrolase activity|glucan-1,6-alpha-glucosidase activity|glucodextranase activity|glucodextrinase http://purl.obolibrary.org/obo/GO_0043896 GO:0102555 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102555 GO:0102554 biolink:MolecularActivity obsolete lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. go.json True http://purl.obolibrary.org/obo/GO_0102554 GO:0043895 biolink:MolecularActivity cyclomaltodextrin glucanotransferase activity Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond. EC:2.4.1.19|MetaCyc:2.4.1.19-RXN go.json 1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)|BMA|Bacillus macerans amylase|CGTase|alpha-1,4-glucan 4-glycosyltransferase, cyclizing|alpha-cyclodextrin glucanotransferase|alpha-cyclodextrin glycosyltransferase|beta-cyclodextrin glucanotransferase|beta-cyclodextrin glycosyltransferase|cyclodextrin glucanotransferase|cyclodextrin glycosyltransferase|cyclomaltodextrin glucotransferase|cyclomaltodextrin glycosyltransferase|gamma-cyclodextrin glycosyltransferase|konchizaimu|neutral-cyclodextrin glycosyltransferase http://purl.obolibrary.org/obo/GO_0043895 GO:0102557 biolink:MolecularActivity protopanaxadiol 6-hydroxylase activity Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ = protopanaxatriol + NADP + H2O. EC:1.14.14.121|MetaCyc:RXN-14978|RHEA:22272 go.json http://purl.obolibrary.org/obo/GO_0102557 GO:0043890 biolink:MolecularActivity N-acetylgalactosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. EC:3.1.6.4|MetaCyc:3.1.6.4-RXN|Reactome:R-HSA-1630304|Reactome:R-HSA-2263490 go.json N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity|N-acetylgalactosamine 6-sulfatase activity|N-acetylgalactosamine-6-sulfate sulfatase activity|acetylgalactosamine 6-sulfatase activity|chondroitin sulfatase|chondroitinase|chondroitinsulfatase|galactose-6-sulfate sulfatase activity http://purl.obolibrary.org/obo/GO_0043890 GO:0102556 biolink:MolecularActivity dammarenediol 12-hydroxylase activity Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 = (20S)-protopanaxadiol + NADP + H2O. EC:1.14.14.120|MetaCyc:RXN-14975|RHEA:38579 go.json http://purl.obolibrary.org/obo/GO_0102556 GO:0043892 biolink:MolecularActivity methylglyoxal reductase (NADPH-dependent) activity Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+. EC:1.1.1.283|MetaCyc:1.1.1.283-RXN|RHEA:21748 go.json Gre2|lactaldehyde dehydrogenase (NADP+)|lactaldehyde:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043892 GO:0102559 biolink:MolecularActivity protein-(glutamine-N5) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine. EC:2.1.1.297|MetaCyc:RXN-14992|RHEA:42896 go.json http://purl.obolibrary.org/obo/GO_0102559 GO:0043891 biolink:MolecularActivity glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+. EC:1.2.1.59|MetaCyc:GAPDHSYNEC-RXN go.json D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)|NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity|glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)|triosephosphate dehydrogenase (NAD(P))|triosephosphate dehydrogenase (NAD(P)+) http://purl.obolibrary.org/obo/GO_0043891 GO:0043898 biolink:MolecularActivity 2,3-dihydroxybiphenyl 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid. go.json 2,3-dihydroxybiphenyl-1,2-dioxygenase activity|BphC http://purl.obolibrary.org/obo/GO_0043898 GO:0043897 biolink:MolecularActivity glucan 1,4-alpha-maltohydrolase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains. EC:3.2.1.133|MetaCyc:3.2.1.133-RXN go.json 1,4-alpha-D-glucan alpha-maltohydrolase activity|glucan-1,4-alpha-maltohydrolase activity|maltogenic alpha-amylase activity http://purl.obolibrary.org/obo/GO_0043897 GO:0043899 biolink:MolecularActivity phosphoserine:homoserine phosphotransferase activity Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine. go.json thrH http://purl.obolibrary.org/obo/GO_0043899 GO:0102560 biolink:MolecularActivity 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = D-ribofuranose 2,5-bisphosphate + H+. EC:3.1.4.57|MetaCyc:RXN-14995|RHEA:41612 go.json phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase http://purl.obolibrary.org/obo/GO_0102560 GO:0102562 biolink:MolecularActivity hydroxyproline O-arbinofuranose transferase activity Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline. MetaCyc:RXN-15011|RHEA:49472 go.json http://purl.obolibrary.org/obo/GO_0102562 GO:0102561 biolink:MolecularActivity D-ribose 2,5-bisphosphate 2-phosphohydrolase activity Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate = hydrogenphosphate + D-ribofuranose 5-phosphate. EC:3.1.4.57|MetaCyc:RXN-14996|RHEA:41616 go.json http://purl.obolibrary.org/obo/GO_0102561 GO:0102564 biolink:MolecularActivity aurachin C epoxide hydrolase/isomerase activity Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H = aurachin B + H2O + NAD(P). MetaCyc:RXN-15030|RHEA:48728 go.json http://purl.obolibrary.org/obo/GO_0102564 GO:0102563 biolink:MolecularActivity aurachin C monooxygenase activity Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H = aurachin C epoxide + H2O + NAD(P). MetaCyc:RXN-15029 go.json http://purl.obolibrary.org/obo/GO_0102563 GO:0102566 biolink:MolecularActivity 1-acyl dihydroxyacetone phosphate reductase activity Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP. EC:1.1.1.101|MetaCyc:RXN-15046 go.json http://purl.obolibrary.org/obo/GO_0102566 GO:0102568 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102568 GO:0102567 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0102567 GO:0102569 biolink:MolecularActivity FR-33289 synthase activity Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 = FR-33289 + succinate(2-) + carbon dioxide. MetaCyc:RXN-15082 go.json http://purl.obolibrary.org/obo/GO_0102569 GO:0102571 biolink:MolecularActivity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine). EC:3.2.1.169|MetaCyc:RXN-15215 go.json http://purl.obolibrary.org/obo/GO_0102571 GO:0102570 biolink:MolecularActivity tyrosine:phenylpyruvate aminotransferase activity Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate. MetaCyc:RXN-15200 go.json http://purl.obolibrary.org/obo/GO_0102570 GO:0102573 biolink:MolecularActivity aminodeoxyfutalosine synthase activity Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O = aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+. EC:2.5.1.120|MetaCyc:RXN-15264|RHEA:33075 go.json http://purl.obolibrary.org/obo/GO_0102573 GO:0102572 biolink:MolecularActivity N-glutamylanilide hydrolase activity Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+. MetaCyc:RXN-15251|RHEA:50684 go.json http://purl.obolibrary.org/obo/GO_0102572 GO:0102575 biolink:MolecularActivity 3-oxo-dodecanoyl-ACP hydrolase activity Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]. MetaCyc:RXN-15281 go.json http://purl.obolibrary.org/obo/GO_0102575 GO:0102574 biolink:MolecularActivity 3-oxo-myristoyl-ACP hydrolase activity Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]. MetaCyc:RXN-15280 go.json http://purl.obolibrary.org/obo/GO_0102574 GO:0102577 biolink:MolecularActivity 3-oxo-palmitate decarboxylase activity Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide. EC:4.1.1.56|MetaCyc:RXN-15283 go.json http://purl.obolibrary.org/obo/GO_0102577 GO:0102576 biolink:MolecularActivity 3-oxo-palmitoyl-ACP hydrolase activity Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]. MetaCyc:RXN-15282 go.json http://purl.obolibrary.org/obo/GO_0102576 GO:0102580 biolink:MolecularActivity cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose = cyanidin 3-O-beta-D-sambubioside + UDP. EC:2.4.2.51|MetaCyc:RXN-15326|RHEA:35443 go.json http://purl.obolibrary.org/obo/GO_0102580 GO:0102582 biolink:MolecularActivity cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+. MetaCyc:RXN-15328 go.json http://purl.obolibrary.org/obo/GO_0102582 GO:0102581 biolink:MolecularActivity cyanidin 3-O-glucoside-p-coumaroyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ = cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A. MetaCyc:RXN-15327 go.json http://purl.obolibrary.org/obo/GO_0102581 GO:0102584 biolink:MolecularActivity cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+. MetaCyc:RXN-15330 go.json http://purl.obolibrary.org/obo/GO_0102584 GO:0102583 biolink:MolecularActivity cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A. MetaCyc:RXN-15329 go.json http://purl.obolibrary.org/obo/GO_0102583 GO:0102586 biolink:MolecularActivity cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose. MetaCyc:RXN-15332 go.json http://purl.obolibrary.org/obo/GO_0102586 GO:0102585 biolink:MolecularActivity cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A. MetaCyc:RXN-15331 go.json http://purl.obolibrary.org/obo/GO_0102585 GO:0102588 biolink:MolecularActivity cyanidin 3-O-glucoside 6''-O-malonyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA = cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A. EC:2.3.1.171|MetaCyc:RXN-15335 go.json http://purl.obolibrary.org/obo/GO_0102588 GO:0102587 biolink:MolecularActivity cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+. MetaCyc:RXN-15333 go.json http://purl.obolibrary.org/obo/GO_0102587 GO:0102589 biolink:MolecularActivity cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) = cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A. MetaCyc:RXN-15336 go.json http://purl.obolibrary.org/obo/GO_0102589 GO:0018807 biolink:MolecularActivity 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA. EC:3.7.1.21|RHEA:39651|UM-BBD_reactionID:r0204 go.json http://purl.obolibrary.org/obo/GO_0018807 GO:0018806 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018806 GO:0018809 biolink:MolecularActivity E-phenylitaconyl-CoA hydratase activity Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA. UM-BBD_reactionID:r0331 go.json http://purl.obolibrary.org/obo/GO_0018809 GO:0018808 biolink:MolecularActivity trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde. UM-BBD_reactionID:r0484 go.json http://purl.obolibrary.org/obo/GO_0018808 GO:0018803 biolink:MolecularActivity 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate. EC:4.1.2.34|MetaCyc:4.1.2.34-RXN|RHEA:16453|UM-BBD_reactionID:r0487 go.json (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity|(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)|(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity|2'-carboxybenzalpyruvate aldolase activity|trans-2'-carboxybenzalpyruvate hydratase-aldolase activity http://purl.obolibrary.org/obo/GO_0018803 GO:0018802 biolink:MolecularActivity 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. UM-BBD_reactionID:r0370 go.json http://purl.obolibrary.org/obo/GO_0018802 GO:0018805 biolink:MolecularActivity benzylsuccinate synthase activity Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate. EC:4.1.99.11|KEGG_REACTION:R05598|MetaCyc:RXN-863|RHEA:10416|UM-BBD_enzymeID:e0259 go.json benzylsuccinate fumarate-lyase (toluene-forming)|benzylsuccinate fumarate-lyase activity http://purl.obolibrary.org/obo/GO_0018805 GO:0018804 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018804 GO:0018801 biolink:MolecularActivity glutaconyl-CoA decarboxylase activity Catalysis of the reaction: trans-glutaconyl-CoA + H+ = but-2-enoyl-CoA + CO2. EC:7.2.4.5|KEGG_REACTION:R03028|MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN|RHEA:23972|UM-BBD_reactionID:r0199 go.json 4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)|4-carboxybut-2-enoyl-CoA carboxy-lyase activity|glutaconyl coenzyme A decarboxylase activity|pent-2-enoyl-CoA carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0018801 GO:0018800 biolink:MolecularActivity 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. EC:4.1.1.68|MetaCyc:4.1.1.68-RXN|RHEA:14397|UM-BBD_reactionID:r0367 go.json 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity|5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity|5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)|5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity|HpaG-2|HpaG2|OPET decarboxylase activity http://purl.obolibrary.org/obo/GO_0018800 GO:0018818 biolink:MolecularActivity acetylene hydratase activity Catalysis of the reaction: acetaldehyde = acetylene + H2O. EC:4.2.1.112|KEGG_REACTION:R05380|MetaCyc:R141-RXN|RHEA:17885|UM-BBD_reactionID:r0591 go.json AH|AHy|acetaldehyde hydro-lyase activity http://purl.obolibrary.org/obo/GO_0018818 GO:0018817 biolink:MolecularActivity 2-oxo-hept-3-ene-1,7-dioate hydratase activity Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN|RHEA:42072|UM-BBD_reactionID:r0369 go.json 2-oxo-hepta-3-ene-1,7-dioate hydratase activity|2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity|HpaH http://purl.obolibrary.org/obo/GO_0018817 GO:0018819 biolink:MolecularActivity lactoyl-CoA dehydratase activity Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O. EC:4.2.1.54|MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN|MetaCyc:RXN-781|RHEA:34691|UM-BBD_reactionID:r0086 go.json acrylyl coenzyme A hydratase activity|lactoyl coenzyme A dehydratase activity|lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)|lactoyl-CoA hydro-lyase activity|lactyl CoA dehydratase activity|lactyl-coenzyme A dehydrase activity http://purl.obolibrary.org/obo/GO_0018819 GO:0018814 biolink:MolecularActivity phenylacetaldoxime dehydratase activity Catalysis of the reaction: (trans)-phenylacetaldoxime = H2O + phenylacetonitrile. EC:4.99.1.7|KEGG_REACTION:R07638|MetaCyc:4.99.1.7-RXN|RHEA:20069|UM-BBD_reactionID:r0697 go.json (Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity|(Z)-phenylacetaldehyde-oxime hydro-lyase activity|OxdB|PAOx dehydratase activity|arylacetaldoxime dehydratase activity http://purl.obolibrary.org/obo/GO_0018814 GO:0018813 biolink:MolecularActivity trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). EC:4.1.2.45|RHEA:27389|UM-BBD_enzymeID:e0257 go.json http://purl.obolibrary.org/obo/GO_0018813 GO:0018816 biolink:MolecularActivity 2-hydroxyisobutyrate dehydratase activity Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate. UM-BBD_reactionID:r0618 go.json http://purl.obolibrary.org/obo/GO_0018816 GO:0018815 biolink:MolecularActivity 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine. MetaCyc:RXN-645|UM-BBD_reactionID:r0051 go.json http://purl.obolibrary.org/obo/GO_0018815 GO:0018810 biolink:MolecularActivity trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene. UM-BBD_reactionID:r0164 go.json http://purl.obolibrary.org/obo/GO_0018810 GO:0018812 biolink:MolecularActivity 3-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O. EC:4.2.1.74|MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN|RHEA:33767|Reactome:R-HSA-2066778|Reactome:R-HSA-2066780|Reactome:R-HSA-389986|Reactome:R-HSA-390252|Reactome:R-HSA-5676637|Reactome:R-HSA-6809263|Reactome:R-HSA-8957389 go.json http://purl.obolibrary.org/obo/GO_0018812 GO:0018811 biolink:MolecularActivity cyclohex-1-ene-1-carboxyl-CoA hydratase activity Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA. MetaCyc:R266-RXN|UM-BBD_reactionID:r0191 go.json http://purl.obolibrary.org/obo/GO_0018811 GO:0043803 biolink:MolecularActivity hydroxyneurosporene-O-methyltransferase activity Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + spheroidene. EC:2.1.1.210|RHEA:30903 go.json 1-HO-carotenoid methylase|1-hydroxycarotenoid O-methylase|1-hydroxycarotenoid methylase|demethylspheroidene O-methyltransferase http://purl.obolibrary.org/obo/GO_0043803 GO:0043802 biolink:MolecularActivity hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H2O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H+ + hydrogenobyrinate a,c-diamide + 2 phosphate. EC:6.3.5.9|KEGG_REACTION:R05224|MetaCyc:R341-RXN|RHEA:12544 go.json CobB|hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity|hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0043802 GO:0043805 biolink:MolecularActivity indolepyruvate ferredoxin oxidoreductase activity Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin. EC:1.2.7.8|MetaCyc:1.2.7.8-RXN|RHEA:12645 go.json 3-(indol-3-yl)pyruvate synthase (ferredoxin) activity|3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)|IOR|indolepyruvate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043805 GO:0043804 biolink:MolecularActivity imidazolone hydrolase activity Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one. RHEA:24935 go.json http://purl.obolibrary.org/obo/GO_0043804 GO:0043801 biolink:MolecularActivity hexulose-6-phosphate synthase activity Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate. EC:4.1.2.43|MetaCyc:R10-RXN|RHEA:25201 go.json http://purl.obolibrary.org/obo/GO_0043801 GO:0043800 biolink:MolecularActivity hexulose-6-phosphate isomerase activity Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate. EC:5.3.1.27|MetaCyc:R12-RXN|RHEA:25900 go.json HUMPI http://purl.obolibrary.org/obo/GO_0043800 GO:0043807 biolink:MolecularActivity 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin. EC:1.2.7.7|MetaCyc:1.2.7.7-RXN|RHEA:11712 go.json 2-ketoisovalerate ferredoxin reductase activity|2-oxoisovalerate ferredoxin reductase activity|3-methyl-2-oxobutanoate synthase (ferredoxin) activity|3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)|VOR|branched-chain ketoacid ferredoxin reductase activity|branched-chain oxo acid ferredoxin reductase activity|keto-valine-ferredoxin oxidoreductase activity|ketoisovalerate ferredoxin reductase activity|ketoisovalerate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043807 GO:0043806 biolink:MolecularActivity keto acid formate lyase activity Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate. EC:2.3.1.-|MetaCyc:KETOBUTFORMLY-RXN go.json keto-acid formate acetyltransferase|keto-acid formate lyase activity|keto-acid formate-lyase activity http://purl.obolibrary.org/obo/GO_0043806 GO:0043809 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043809 GO:0043808 biolink:MolecularActivity lyso-ornithine lipid acyltransferase activity Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]. go.json http://purl.obolibrary.org/obo/GO_0043808 GO:0043814 biolink:MolecularActivity phospholactate guanylyltransferase activity Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate. EC:2.7.7.68|RHEA:63424 go.json http://purl.obolibrary.org/obo/GO_0043814 GO:0043813 biolink:MolecularActivity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. RHEA:32955|Reactome:R-HSA-1675836|Reactome:R-HSA-1676005|Reactome:R-HSA-1676020|Reactome:R-HSA-1676174 go.json phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity http://purl.obolibrary.org/obo/GO_0043813 GO:0043816 biolink:MolecularActivity phosphoserine-tRNA(Cys) ligase activity Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys). EC:6.1.1.27|RHEA:25678 go.json O-phosphoseryl-tRNA(Cys) synthetase activity|SepRS|phosphoserine--tRNA(Cys) ligase activity|phosphoserine-tRNACys ligase activity http://purl.obolibrary.org/obo/GO_0043816 GO:0043815 biolink:MolecularActivity phosphoribosylglycinamide formyltransferase 2 activity Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. MetaCyc:GARTRANSFORMYL2-RXN|RHEA:24829 go.json 5'-phosphoribosylglycinamide transformylase 2|GAR transformylase 2|GART 2|formate-dependent GAR transformylase activity http://purl.obolibrary.org/obo/GO_0043815 GO:0043810 biolink:MolecularActivity ornithine-acyl [acyl carrier protein] N-acyltransferase activity Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. EC:2.3.2.30|RHEA:20633 go.json L-ornithine N(alpha)-acyltransferase|ornithine-acyl[acyl carrier protein] N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0043810 GO:0043812 biolink:MolecularActivity phosphatidylinositol-4-phosphate phosphatase activity Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate. RHEA:55652 go.json phosphatidylinositol 4-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0043812 GO:0043811 biolink:MolecularActivity phosphate:acyl-[acyl carrier protein] acyltransferase activity Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]. EC:2.3.1.274|RHEA:42292 go.json http://purl.obolibrary.org/obo/GO_0043811 GO:0043818 biolink:MolecularActivity precorrin-3B synthase activity Catalysis of the reaction: H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B. EC:1.14.13.83|KEGG_REACTION:R05217|MetaCyc:R321-RXN|RHEA:17293 go.json CobG|precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)|precorrin-3X synthase activity http://purl.obolibrary.org/obo/GO_0043818 GO:0043817 biolink:MolecularActivity phosphosulfolactate synthase activity Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite. EC:4.4.1.19|KEGG_REACTION:R07476|MetaCyc:ABC-16-RXN|RHEA:22784 go.json (2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)|(2R)-O-phospho-3-sulfolactate sulfo-lyase activity|(2R)-phospho-3-sulfolactate synthase activity|PSL synthase activity http://purl.obolibrary.org/obo/GO_0043817 GO:0043819 biolink:MolecularActivity precorrin-6A synthase (deacetylating) activity Catalysis of the reaction: S-adenosyl-L-methionine + H2O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H+ + precorrin-6X. EC:2.1.1.152|KEGG_REACTION:R05219|MetaCyc:R322-RXN|RHEA:18261 go.json CobF|S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)|precorrin-6X synthase (deacetylating) activity http://purl.obolibrary.org/obo/GO_0043819 GO:0043825 biolink:MolecularActivity succinylornithine transaminase activity Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate. EC:2.6.1.81|KEGG_REACTION:R04217|MetaCyc:SUCCORNTRANSAM-RXN|RHEA:16953 go.json 2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity|AstC|N(2)-succinylornithine 5-aminotransferase activity|N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity|N2-succinylornithine 5-aminotransferase activity|SOAT|succinyl ornithine transaminase activity|succinyl-ornithine transaminase activity|succinylornithine aminotransferase activity http://purl.obolibrary.org/obo/GO_0043825 GO:0043824 biolink:MolecularActivity succinylglutamate-semialdehyde dehydrogenase activity Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H2O + NAD+ = N-succinyl-L-glutamate + 2 H+ + NADH. EC:1.2.1.71|KEGG_REACTION:R05049|MetaCyc:SUCCGLUALDDEHYD-RXN|RHEA:10812 go.json AruD|AstD|N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity|N-succinylglutamate 5-semialdehyde dehydrogenase activity|SGSD|succinyl glutamate-semialdehyde dehydrogenase activity|succinylglutamic semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0043824 GO:0043827 biolink:MolecularActivity tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity Catalysis of the reaction: adenosine57/adenosine58 in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N1-methyladenosine57/N1-methyladenosine58 in tRNA + 2 S-adenosyl-L-homocysteine. EC:2.1.1.219|RHEA:41740 go.json tRNA (adenine(57)-N(1))/(adenine(58)-N(1))-methyltransferase activity|tRNA (adenine(57)-N1-)/(adenine(58)-N1-)-methyltransferase activity|tRNA (adenine(57)-N1-/adenine(58)-N1-)-methyltransferase activity|tRNA (adenine-57, 58 N1-) methyltransferase activity|tRNA (adenine-57, 58-N(1)-) methyltransferase activity|tRNA (adenine-57, 58-N1-) methyltransferase activity http://purl.obolibrary.org/obo/GO_0043827 GO:0043826 biolink:MolecularActivity sulfur oxygenase reductase activity Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+. MetaCyc:RXN-8226 go.json SOR|sulphur oxygenase reductase activity http://purl.obolibrary.org/obo/GO_0043826 GO:0043821 biolink:MolecularActivity propionyl-CoA:succinate CoA-transferase activity Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate. MetaCyc:RXN0-268|RHEA:28010 go.json propionyl-CoA succinate CoA-transferase activity|propionyl-CoA:succinate CoA transferase activity http://purl.obolibrary.org/obo/GO_0043821 GO:0043820 biolink:MolecularActivity propionyl-CoA dehydrogenase activity Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA. EC:1.3.99.- go.json http://purl.obolibrary.org/obo/GO_0043820 GO:0043823 biolink:MolecularActivity spheroidene monooxygenase activity Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O. EC:1.14.15.9|MetaCyc:RXN-10670|RHEA:33027 go.json http://purl.obolibrary.org/obo/GO_0043823 GO:0043822 biolink:MolecularActivity ribonuclease M5 activity Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor. EC:3.1.26.8|MetaCyc:3.1.26.8-RXN go.json 5S ribosomal RNA maturation endonuclease activity|5S ribosomal maturation nuclease activity|RNase M5 activity http://purl.obolibrary.org/obo/GO_0043822 GO:0043829 biolink:MolecularActivity tRNA-specific adenosine-37 deaminase activity Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule. EC:3.5.4.34|RHEA:50968 go.json TAD1|tRNA(Ala)-A37 deaminase activity|tRNA-specific adenosine deaminase 1 http://purl.obolibrary.org/obo/GO_0043829 GO:0043828 biolink:MolecularActivity tRNA 2-selenouridine synthase activity Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA). EC:2.9.1.3|MetaCyc:RXN0-2281|RHEA:42716 go.json http://purl.obolibrary.org/obo/GO_0043828 GO:0043830 biolink:MolecularActivity thiol-driven fumarate reductase activity Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide. EC:1.3.99.- go.json http://purl.obolibrary.org/obo/GO_0043830 GO:0043836 biolink:MolecularActivity xanthine hydrolase activity Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate. MetaCyc:R127-RXN go.json xanthinase activity http://purl.obolibrary.org/obo/GO_0043836 GO:0043835 biolink:MolecularActivity obsolete uracil/thymine dehydrogenase activity OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor. EC:1.17.99.4 go.json uracil oxidase activity|uracil-thymine oxidase activity|uracil/thymine dehydrogenase activity|uracil:acceptor oxidoreductase activity True http://purl.obolibrary.org/obo/GO_0043835 GO:0043838 biolink:MolecularActivity phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol. go.json EptB|phosphoethanolamine transferase http://purl.obolibrary.org/obo/GO_0043838 GO:0043837 biolink:MolecularActivity valine dehydrogenase (NAD) activity Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. EC:1.4.1.23|RHEA:30763 go.json ValDH http://purl.obolibrary.org/obo/GO_0043837 GO:0043832 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043832 GO:0043831 biolink:MolecularActivity thiosulfate dehydrogenase (quinone) activity Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate. EC:1.8.5.2|KEGG_REACTION:R07177|MetaCyc:1.8.5.2-RXN|RHEA:10936 go.json DoxA|DoxD|TQO|thiosulfate oxidoreductase, tetrathionate-forming activity|thiosulfate:6-decylubiquinone oxidoreductase activity|thiosulfate:quinone oxidoreductase activity|thiosulphate dehydrogenase (quinone) activity|thiosulphate:quinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0043831 GO:0043834 biolink:MolecularActivity trimethylamine methyltransferase activity Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine. EC:2.1.1.250|MetaCyc:RXN-8102|RHEA:39287 go.json MT1|TMA methyltransferase 1|mttB1|trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity|trimethylamine:corrinoid methyltransferase activity http://purl.obolibrary.org/obo/GO_0043834 GO:0043833 biolink:MolecularActivity [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M. EC:2.1.1.247|MetaCyc:RXN-8099|MetaCyc:RXN-8101|MetaCyc:RXN-8103|RHEA:18773 go.json MT2-A|methylamine-specific methylcobalamin:CoM methyltransferase activity|methylamine-specific methylcobalamin:coenzyme M methyltransferase activity|methylcobamide:CoM methyltransferase activity|methylcobamide:coenzyme M methyltransferase activity|monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity http://purl.obolibrary.org/obo/GO_0043833 GO:0043839 biolink:MolecularActivity lipid A phosphate methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A. go.json LmtA|lipid A 1-phosphomethyltransferase activity|lipid A methyltransferase|lipid A phosphomethyltransferase activity http://purl.obolibrary.org/obo/GO_0043839 GO:0043841 biolink:MolecularActivity (S)-lactate 2-kinase activity Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP. MetaCyc:RXN-8076 go.json lactate 2-kinase activity http://purl.obolibrary.org/obo/GO_0043841 GO:0043840 biolink:MolecularActivity branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine. MetaCyc:RXN-7708 go.json BCAT|branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity|branched-chain amino acid aminotransferase|branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity http://purl.obolibrary.org/obo/GO_0043840 GO:0043847 biolink:CellularComponent DNA polymerase III, clamp loader chi/psi subcomplex A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB). go.json DNA polymerase III, DnaX complex, chi/psi subcomplex http://purl.obolibrary.org/obo/GO_0043847 GO:0043846 biolink:CellularComponent DNA polymerase III, clamp loader complex A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. go.json DNA polymerase III, DnaX complex|DNA polymerase III, DnaX subcomplex|clamp loader complex http://purl.obolibrary.org/obo/GO_0043846 GO:0043849 biolink:MolecularActivity Ras palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins. go.json DHHC cysteine-rich domain-containing protein ERF2|ERF2|Ras protein acyltransferase activity|palmitoyltransferase ERF2 http://purl.obolibrary.org/obo/GO_0043849 GO:0043848 biolink:MolecularActivity obsolete excinuclease cho activity OBSOLETE. Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage. go.json cho|endonuclease cho|uvrc homolog protein True http://purl.obolibrary.org/obo/GO_0043848 GO:0043843 biolink:MolecularActivity ADP-specific glucokinase activity Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate. EC:2.7.1.147|RHEA:11460|Reactome:R-HSA-5696021 go.json ADP-dependent glucokinase activity|ADP:D-glucose 6-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0043843 GO:0043842 biolink:MolecularActivity Kdo transferase activity Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP. EC:2.4.99.12|EC:2.4.99.13|EC:2.4.99.14|EC:2.4.99.15|MetaCyc:KDOTRANS-RXN|MetaCyc:KDOTRANS2-RXN go.json 3-deoxy-D-manno-octulosonic-acid transferase activity|WaaA|kdtA http://purl.obolibrary.org/obo/GO_0043842 GO:0043845 biolink:CellularComponent DNA polymerase III, proofreading complex A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity. go.json DNA polymerase III, proof-reading complex|DNA polymerase III, proof-reading subcomplex|DNA polymerase III, proofreading subcomplex http://purl.obolibrary.org/obo/GO_0043845 GO:0043844 biolink:MolecularActivity ADP-specific phosphofructokinase activity Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate. EC:2.7.1.146|RHEA:20105 go.json ADP-6-phosphofructokinase activity|ADP-Pfk activity|ADP-dependent phosphofructokinase activity|ADP:D-fructose-6-phosphate 1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0043844 GO:0004249 biolink:MolecularActivity obsolete stromelysin 3 activity OBSOLETE. Was not defined before being made obsolete. go.json MMP-11|matrix metalloproteinase 11|stromelysin 3 activity True http://purl.obolibrary.org/obo/GO_0004249 GO:0004246 biolink:MolecularActivity obsolete peptidyl-dipeptidase A activity OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II. EC:3.4.15.1|MetaCyc:3.4.15.1-RXN go.json ACE activity|DCP|PDH|angiotensin I-converting enzyme activity|angiotensin converting enzyme|carboxycathepsin activity|dipeptide hydrolase|dipeptidyl carboxypeptidase I activity|endothelial cell peptidyl dipeptidase activity|kininase II activity|peptidase P activity|peptidyl dipeptidase A|peptidyl dipeptidase I activity|peptidyl dipeptidase-4|peptidyl dipeptide hydrolase activity|peptidyl-dipeptidase A activity|peptidyl-dipeptide hydrolase activity|peptidyldipeptide hydrolase activity True http://purl.obolibrary.org/obo/GO_0004246 GO:0004245 biolink:MolecularActivity obsolete neprilysin activity OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides. go.json CALLA|CALLA (common acute lymphoblastic leukemia-associated) antigens|CALLA antigen|CALLA glycoprotein|CALLA glycoproteins|CD10|acute lymphoblastic leukemia antigen|common acute lymphoblastic leukemia antigen|common acute lymphoblastic leukemia-associated antigens|endopeptidase 24.11|endopeptidase-2 activity|enkephalinase activity|kidney-brush-border neutral endopeptidase|kidney-brush-border neutral peptidase|kidney-brush-border neutral proteinase activity|membrane metalloendopeptidase activity|neprilysin activity|neutral endopeptidase 24.11|neutral endopeptidase activity|neutral metallendopeptidase activity True http://purl.obolibrary.org/obo/GO_0004245 GO:0004248 biolink:MolecularActivity obsolete stromelysin 1 activity OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues. go.json MMP-3|collagen-activating protein|collagenase activating protein|matrix metalloproteinase 3 activity|neutral proteoglycanase activity|procollagenase activator|proteoglycanase activity|stromelysin|stromelysin 1 activity|transin activity True http://purl.obolibrary.org/obo/GO_0004248 GO:0004247 biolink:MolecularActivity obsolete saccharolysin activity OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds. go.json oligopeptidase yscD activity|proteinase yscD activity|saccharolysin activity|saccharomyces cerevisiae proteinase yscD|yeast cysteine proteinase D activity True http://purl.obolibrary.org/obo/GO_0004247 GO:0004242 biolink:MolecularActivity obsolete beta-mitochondrial processing peptidase OBSOLETE. (Was not defined before being made obsolete). go.json beta-MPP|beta-mitochondrial processing peptidase True http://purl.obolibrary.org/obo/GO_0004242 GO:0004241 biolink:MolecularActivity obsolete alpha-mitochondrial processing peptidase OBSOLETE. (Was not defined before being made obsolete). go.json alpha-MPP|alpha-mitochondrial processing peptidase True http://purl.obolibrary.org/obo/GO_0004241 GO:0004244 biolink:MolecularActivity obsolete mitochondrial inner membrane peptidase activity OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space. go.json IMP|mitochondrial inner membrane peptidase activity True http://purl.obolibrary.org/obo/GO_0004244 GO:0004243 biolink:MolecularActivity obsolete mitochondrial intermediate peptidase activity OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion. go.json MIP|mitochondrial intermediate peptidase activity|mitochondrial intermediate precursor-processing proteinase activity True http://purl.obolibrary.org/obo/GO_0004243 GO:0004240 biolink:MolecularActivity obsolete mitochondrial processing peptidase activity OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2. go.json MPP|alpha-mitochondrial processing peptidase|beta-mitochondrial processing peptidase|matrix peptidase|matrix processing peptidase|matrix processing proteinase|mitochondrial processing peptidase activity|mitochondrial protein precursor-processing proteinase activity|processing enhancing peptidase (for one of two subunits)|processing enhancing peptidase activity True http://purl.obolibrary.org/obo/GO_0004240 GO:0018887 biolink:BiologicalProcess 4-carboxy-4'-sulfoazobenzene metabolic process The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid. UM-BBD_pathwayID:csab go.json 4-carboxy-4'-sulfoazobenzene metabolism|4-carboxy-4'-sulphoazobenzene metabolic process|4-carboxy-4'-sulphoazobenzene metabolism http://purl.obolibrary.org/obo/GO_0018887 GO:0018886 biolink:BiologicalProcess anaerobic carbon tetrachloride metabolic process The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen. UM-BBD_pathwayID:ctc go.json anaerobic carbon tetrachloride metabolism http://purl.obolibrary.org/obo/GO_0018886 GO:0018889 biolink:BiologicalProcess 2-chloro-N-isopropylacetanilide metabolic process The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. UM-BBD_pathwayID:ppc go.json 2-chloro-N-isopropylacetanilide metabolism|propachlor metabolic process|propachlor metabolism http://purl.obolibrary.org/obo/GO_0018889 GO:0018888 biolink:BiologicalProcess 3-chloroacrylic acid metabolic process The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid. UM-BBD_pathwayID:caa go.json 3-chloroacrylic acid metabolism http://purl.obolibrary.org/obo/GO_0018888 GO:0018883 biolink:BiologicalProcess caprolactam metabolic process The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation. UM-BBD_pathwayID:cap go.json caprolactam metabolism http://purl.obolibrary.org/obo/GO_0018883 GO:0018882 biolink:BiologicalProcess (+)-camphor metabolic process The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed. UM-BBD_pathwayID:cam go.json (+)-camphor metabolism|camphor metabolic process|camphor metabolism http://purl.obolibrary.org/obo/GO_0018882 GO:0018885 biolink:BiologicalProcess carbon tetrachloride metabolic process The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. UM-BBD_pathwayID:ctc go.json carbon tetrachloride metabolism http://purl.obolibrary.org/obo/GO_0018885 GO:0018884 biolink:BiologicalProcess carbazole metabolic process The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. UM-BBD_pathwayID:car go.json CAR metabolic process|CAR metabolism|carbazole metabolism http://purl.obolibrary.org/obo/GO_0018884 GO:0018881 biolink:BiologicalProcess bromoxynil metabolic process The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants. UM-BBD_pathwayID:box go.json bromoxynil metabolism http://purl.obolibrary.org/obo/GO_0018881 GO:0018880 biolink:BiologicalProcess 4-chlorobiphenyl metabolic process The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation. UM-BBD_pathwayID:cbp go.json 4-chlorobiphenyl metabolism http://purl.obolibrary.org/obo/GO_0018880 GO:0004258 biolink:MolecularActivity obsolete vacuolar carboxypeptidase Y OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity. go.json vacuolar carboxypeptidase Y True http://purl.obolibrary.org/obo/GO_0004258 GO:0004253 biolink:MolecularActivity obsolete gamma-renin activity OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide. go.json gamma-renin activity True http://purl.obolibrary.org/obo/GO_0004253 GO:0004252 biolink:MolecularActivity serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). EC:3.4.21.-|Reactome:R-HSA-114697|Reactome:R-HSA-1181152|Reactome:R-HSA-139893|Reactome:R-HSA-140599|Reactome:R-HSA-140664|Reactome:R-HSA-140696|Reactome:R-HSA-140700|Reactome:R-HSA-140736|Reactome:R-HSA-140769|Reactome:R-HSA-140777|Reactome:R-HSA-140823|Reactome:R-HSA-140840|Reactome:R-HSA-140870|Reactome:R-HSA-141026|Reactome:R-HSA-141040|Reactome:R-HSA-1454843|Reactome:R-HSA-1474197|Reactome:R-HSA-1566962|Reactome:R-HSA-1566979|Reactome:R-HSA-1566981|Reactome:R-HSA-158137|Reactome:R-HSA-158164|Reactome:R-HSA-158300|Reactome:R-HSA-158311|Reactome:R-HSA-158313|Reactome:R-HSA-158333|Reactome:R-HSA-158419|Reactome:R-HSA-158744|Reactome:R-HSA-158747|Reactome:R-HSA-158750|Reactome:R-HSA-158766|Reactome:R-HSA-158925|Reactome:R-HSA-158942|Reactome:R-HSA-158982|Reactome:R-HSA-1592270|Reactome:R-HSA-1592278|Reactome:R-HSA-1592297|Reactome:R-HSA-1592314|Reactome:R-HSA-1592316|Reactome:R-HSA-1592362|Reactome:R-HSA-1592371|Reactome:R-HSA-1592398|Reactome:R-HSA-1592436|Reactome:R-HSA-159728|Reactome:R-HSA-159733|Reactome:R-HSA-159771|Reactome:R-HSA-159773|Reactome:R-HSA-159796|Reactome:R-HSA-159868|Reactome:R-HSA-1602458|Reactome:R-HSA-1602466|Reactome:R-HSA-1602473|Reactome:R-HSA-1602484|Reactome:R-HSA-1602488|Reactome:R-HSA-1604359|Reactome:R-HSA-1604360|Reactome:R-HSA-1604368|Reactome:R-HSA-1604690|Reactome:R-HSA-1604712|Reactome:R-HSA-1604722|Reactome:R-HSA-1604731|Reactome:R-HSA-1604732|Reactome:R-HSA-1604741|Reactome:R-HSA-1604752|Reactome:R-HSA-1604763|Reactome:R-HSA-163798|Reactome:R-HSA-163843|Reactome:R-HSA-1655842|Reactome:R-HSA-166753|Reactome:R-HSA-166792|Reactome:R-HSA-166817|Reactome:R-HSA-170844|Reactome:R-HSA-171288|Reactome:R-HSA-173626|Reactome:R-HSA-173631|Reactome:R-HSA-173680|Reactome:R-HSA-173745|Reactome:R-HSA-174551|Reactome:R-HSA-1799329|Reactome:R-HSA-183122|Reactome:R-HSA-183130|Reactome:R-HSA-186785|Reactome:R-HSA-187020|Reactome:R-HSA-1912369|Reactome:R-HSA-1912372|Reactome:R-HSA-2022411|Reactome:R-HSA-2129357|Reactome:R-HSA-2168923|Reactome:R-HSA-2168960|Reactome:R-HSA-2172405|Reactome:R-HSA-2214330|Reactome:R-HSA-2471621|Reactome:R-HSA-2471842|Reactome:R-HSA-2482180|Reactome:R-HSA-2514772|Reactome:R-HSA-2514823|Reactome:R-HSA-2534160|Reactome:R-HSA-2534206|Reactome:R-HSA-2534260|Reactome:R-HSA-265301|Reactome:R-HSA-3266557|Reactome:R-HSA-3785684|Reactome:R-HSA-3788061|Reactome:R-HSA-381135|Reactome:R-HSA-381446|Reactome:R-HSA-381461|Reactome:R-HSA-381466|Reactome:R-HSA-3814820|Reactome:R-HSA-381500|Reactome:R-HSA-381798|Reactome:R-HSA-382061|Reactome:R-HSA-3928657|Reactome:R-HSA-400459|Reactome:R-HSA-400492|Reactome:R-HSA-400496|Reactome:R-HSA-422021|Reactome:R-HSA-422051|Reactome:R-HSA-5210912|Reactome:R-HSA-5210935|Reactome:R-HSA-5578783|Reactome:R-HSA-5591040|Reactome:R-HSA-5607002|Reactome:R-HSA-5691512|Reactome:R-HSA-6800198|Reactome:R-HSA-6800200|Reactome:R-HSA-6800299|Reactome:R-HSA-6801687|Reactome:R-HSA-6807224|Reactome:R-HSA-8849826|Reactome:R-HSA-8849857|Reactome:R-HSA-8850831|Reactome:R-HSA-8852716|Reactome:R-HSA-8855825|Reactome:R-HSA-8865275|Reactome:R-HSA-8865276|Reactome:R-HSA-8874145|Reactome:R-HSA-8874186|Reactome:R-HSA-8874204|Reactome:R-HSA-8874205|Reactome:R-HSA-8874206|Reactome:R-HSA-8874212|Reactome:R-HSA-9023178|Reactome:R-HSA-9023196|Reactome:R-HSA-9023626|Reactome:R-HSA-9023627|Reactome:R-HSA-9023632|Reactome:R-HSA-9023633|Reactome:R-HSA-9033490|Reactome:R-HSA-9033506|Reactome:R-HSA-9033515|Reactome:R-HSA-9033520|Reactome:R-HSA-9033524|Reactome:R-HSA-9033529|Reactome:R-HSA-9033530|Reactome:R-HSA-9653249|Reactome:R-HSA-9655046|Reactome:R-HSA-9662786|Reactome:R-HSA-9666383|Reactome:R-HSA-9668253|Reactome:R-HSA-9668365|Reactome:R-HSA-9670874|Reactome:R-HSA-9673223|Reactome:R-HSA-9686710|Reactome:R-HSA-9686731|Reactome:R-HSA-9694287|Reactome:R-HSA-9694661|Reactome:R-HSA-9698988|Reactome:R-HSA-9699007|Reactome:R-HSA-9708859|Reactome:R-HSA-9710106|Reactome:R-HSA-9710263|Reactome:R-HSA-976743|Reactome:R-HSA-9769949|Reactome:R-HSA-9770187|Reactome:R-HSA-977371|Reactome:R-HSA-977615 go.json blood coagulation factor activity|serine elastase activity http://purl.obolibrary.org/obo/GO_0004252 goslim_chembl GO:0004254 biolink:MolecularActivity obsolete acylaminoacyl-peptidase activity OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide. go.json N-acylpeptide hydrolase activity|N-formylmethionine (fMet) aminopeptidase activity|acylamino-acid-releasing enzyme activity|acylaminoacyl-peptidase activity|alpha-N-acylpeptide hydrolase activity True http://purl.obolibrary.org/obo/GO_0004254 GO:0004251 biolink:MolecularActivity obsolete X-Pro dipeptidase activity OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro. EC:3.4.13.9|MetaCyc:3.4.13.9-RXN go.json X-Pro dipeptidase activity|Xaa-Pro dipeptidase activity|gamma-peptidase activity|imidodipeptidase activity|peptidase D|prolidase activity|proline dipeptidase activity True http://purl.obolibrary.org/obo/GO_0004251 GO:0004250 biolink:MolecularActivity obsolete aminopeptidase I activity OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates. EC:3.4.11.22|MetaCyc:3.4.11.22-RXN go.json aminopeptidase I activity|aminopeptidase III activity|aminopeptidase yscI activity|leucine aminopeptidase IV activity|vacuolar aminopeptidase I activity|yeast aminopeptidase I True http://purl.obolibrary.org/obo/GO_0004250 GO:0018898 biolink:BiologicalProcess 2,4-dichlorobenzoate metabolic process The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). UM-BBD_pathwayID:dcb go.json 2,4-dichlorobenzoate metabolism http://purl.obolibrary.org/obo/GO_0018898 GO:0018897 biolink:BiologicalProcess dibenzothiophene desulfurization The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. MetaCyc:PWY-681|UM-BBD_pathwayID:dbt go.json dibenzothiophene desulphurization http://purl.obolibrary.org/obo/GO_0018897 GO:0018899 biolink:BiologicalProcess 1,2-dichloroethane metabolic process The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride. UM-BBD_pathwayID:dce go.json 1,2-dichloroethane metabolism http://purl.obolibrary.org/obo/GO_0018899 GO:0018894 biolink:BiologicalProcess dibenzo-p-dioxin metabolic process The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern. UM-BBD_pathwayID:dpd go.json dibenzo-p-dioxin metabolism|oxanthrene metabolic process|oxanthrene metabolism|phenodioxin metabolic process|phenodioxin metabolism http://purl.obolibrary.org/obo/GO_0018894 GO:0018893 biolink:BiologicalProcess dibenzofuran metabolic process The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals. UM-BBD_pathwayID:dbf go.json dibenzofuran metabolism http://purl.obolibrary.org/obo/GO_0018893 GO:0018896 biolink:BiologicalProcess dibenzothiophene catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. UM-BBD_pathwayID:dbt2 go.json dibenzothiophene breakdown|dibenzothiophene catabolism|dibenzothiophene degradation http://purl.obolibrary.org/obo/GO_0018896 GO:0018895 biolink:BiologicalProcess dibenzothiophene metabolic process The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion. go.json dibenzothiophene metabolism|diphenylene sulfide metabolic process|diphenylene sulfide metabolism http://purl.obolibrary.org/obo/GO_0018895 GO:0018890 biolink:BiologicalProcess cyanamide metabolic process The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism. UM-BBD_pathwayID:cnm go.json cyanamide metabolism http://purl.obolibrary.org/obo/GO_0018890 GO:0018892 biolink:BiologicalProcess cyclohexylsulfamate metabolic process The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide. UM-BBD_pathwayID:chs go.json cyclohexylsulfamate metabolism|cyclohexylsulphamate metabolic process|cyclohexylsulphamate metabolism http://purl.obolibrary.org/obo/GO_0018892 GO:0018891 biolink:BiologicalProcess cyclohexanol metabolic process The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent. UM-BBD_pathwayID:chx go.json cyclohexanol metabolism http://purl.obolibrary.org/obo/GO_0018891 GO:0004228 biolink:MolecularActivity obsolete gelatinase A activity OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond. go.json 3/4 collagenase activity|72 kDa gelatinase type A|72-kDa gelatinase activity|MMP 2|MMP-2|collagenase IV|collagenase type IV|gelatinase A activity|matrix metalloproteinase 2 activity|matrix metalloproteinase 5|type IV collagen metalloproteinase|type IV collagenase activity|type IV collagenase/gelatinase activity True http://purl.obolibrary.org/obo/GO_0004228 GO:0004229 biolink:MolecularActivity obsolete gelatinase B activity OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V. go.json 92-kDa gelatinase activity|92-kDa type IV collagenase activity|95 kDa type IV collagenase/gelatinase activity|MMP 9|MMP-9|collagenase IV|collagenase type IV|gelatinase B activity|gelatinase MMP 9|macrophage gelatinase activity|matrix metalloproteinase 9 activity|type IV collagen metalloproteinase|type V collagenase activity True http://purl.obolibrary.org/obo/GO_0004229 GO:0004226 biolink:MolecularActivity obsolete Gly-X carboxypeptidase activity OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa. go.json Gly-X carboxypeptidase activity|Gly-Xaa carboxypeptidase activity|carboxypeptidase S activity|carboxypeptidase a|glycine carboxypeptidase activity|peptidase alpha|yeast carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0004226 GO:0004220 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0004220 GO:0004222 biolink:MolecularActivity metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. EC:3.4.24.-|Reactome:R-HSA-1168777|Reactome:R-HSA-1251992|Reactome:R-HSA-1299476|Reactome:R-HSA-1299478|Reactome:R-HSA-1454757|Reactome:R-HSA-1454822|Reactome:R-HSA-1458433|Reactome:R-HSA-1474196|Reactome:R-HSA-1474210|Reactome:R-HSA-1474213|Reactome:R-HSA-1564112|Reactome:R-HSA-1564117|Reactome:R-HSA-1564120|Reactome:R-HSA-1564142|Reactome:R-HSA-1564143|Reactome:R-HSA-1564164|Reactome:R-HSA-1564169|Reactome:R-HSA-1564179|Reactome:R-HSA-1564184|Reactome:R-HSA-1592310|Reactome:R-HSA-1655851|Reactome:R-HSA-177946|Reactome:R-HSA-181567|Reactome:R-HSA-194793|Reactome:R-HSA-194796|Reactome:R-HSA-194800|Reactome:R-HSA-194808|Reactome:R-HSA-194809|Reactome:R-HSA-194818|Reactome:R-HSA-2002428|Reactome:R-HSA-2002440|Reactome:R-HSA-2022141|Reactome:R-HSA-2168046|Reactome:R-HSA-2168982|Reactome:R-HSA-2179402|Reactome:R-HSA-2473584|Reactome:R-HSA-2473594|Reactome:R-HSA-2473596|Reactome:R-HSA-2484882|Reactome:R-HSA-2485111|Reactome:R-HSA-2485148|Reactome:R-HSA-2514790|Reactome:R-HSA-2514831|Reactome:R-HSA-2533874|Reactome:R-HSA-2533944|Reactome:R-HSA-2533950|Reactome:R-HSA-2533965|Reactome:R-HSA-2533970|Reactome:R-HSA-2534240|Reactome:R-HSA-2534248|Reactome:R-HSA-2537499|Reactome:R-HSA-264758|Reactome:R-HSA-3371385|Reactome:R-HSA-3788075|Reactome:R-HSA-3791149|Reactome:R-HSA-3791155|Reactome:R-HSA-3791295|Reactome:R-HSA-3791319|Reactome:R-HSA-381435|Reactome:R-HSA-381518|Reactome:R-HSA-381537|Reactome:R-HSA-3827958|Reactome:R-HSA-3828025|Reactome:R-HSA-4086205|Reactome:R-HSA-420818|Reactome:R-HSA-4224014|Reactome:R-HSA-5228578|Reactome:R-HSA-5250606|Reactome:R-HSA-5250892|Reactome:R-HSA-5250962|Reactome:R-HSA-5250978|Reactome:R-HSA-5333671|Reactome:R-HSA-5362793|Reactome:R-HSA-5694082|Reactome:R-HSA-6784620|Reactome:R-HSA-8867344|Reactome:R-HSA-8874122|Reactome:R-HSA-8874187|Reactome:R-HSA-8874192|Reactome:R-HSA-8874194|Reactome:R-HSA-8874195|Reactome:R-HSA-8874201|Reactome:R-HSA-8876868|Reactome:R-HSA-8877620|Reactome:R-HSA-8940554|Reactome:R-HSA-8940561|Reactome:R-HSA-8940641|Reactome:R-HSA-8940959|Reactome:R-HSA-8942302|Reactome:R-HSA-8943959|Reactome:R-HSA-8949649|Reactome:R-HSA-8949659|Reactome:R-HSA-8949668|Reactome:R-HSA-9624272 go.json metalloendoprotease activity|metalloendoproteinase activity http://purl.obolibrary.org/obo/GO_0004222 GO:0004221 biolink:MolecularActivity obsolete ubiquitin thiolesterase activity OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. KEGG_REACTION:R02418|MetaCyc:UBIQUITIN-THIOLESTERASE-RXN go.json ubiquitin C-terminal hydrolase activity|ubiquitin carboxy-terminal esterase activity|ubiquitin carboxy-terminal hydrolase activity|ubiquitin thioesterase activity|ubiquitin thiolesterase activity|ubiquitin-C-terminal-thioester hydrolase activity|ubiquitinyl hydrolase 1 activity True http://purl.obolibrary.org/obo/GO_0004221 GO:0018869 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018869 GO:0018868 biolink:BiologicalProcess 2-aminobenzenesulfonate metabolic process The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. UM-BBD_pathwayID:abs go.json 2-aminobenzenesulfonate metabolism|2-aminobenzenesulphonate metabolic process|2-aminobenzenesulphonate metabolism http://purl.obolibrary.org/obo/GO_0018868 GO:0018865 biolink:BiologicalProcess acrylonitrile metabolic process The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. UM-BBD_pathwayID:acr go.json acrylonitrile metabolism http://purl.obolibrary.org/obo/GO_0018865 GO:0018864 biolink:BiologicalProcess acetylene metabolic process The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes. UM-BBD_pathwayID:atl go.json acetylene metabolism|ethyne metabolic process|ethyne metabolism http://purl.obolibrary.org/obo/GO_0018864 GO:0018867 biolink:BiologicalProcess alpha-pinene metabolic process The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor. UM-BBD_pathwayID:apn go.json alpha-pinene metabolism http://purl.obolibrary.org/obo/GO_0018867 GO:0018866 biolink:BiologicalProcess adamantanone metabolic process The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. UM-BBD_pathwayID:ada go.json adamantanone metabolism http://purl.obolibrary.org/obo/GO_0018866 GO:0018861 biolink:MolecularActivity 4-chlorobenzoate-CoA ligase activity Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway. EC:6.2.1.33|KEGG_REACTION:R03932|MetaCyc:6.2.1.33-RXN|RHEA:23220|UM-BBD_reactionID:r0139 go.json 4-chlorobenzoate:CoA ligase activity http://purl.obolibrary.org/obo/GO_0018861 GO:0018860 biolink:MolecularActivity anthranilate-CoA ligase activity Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA. EC:6.2.1.32|KEGG_REACTION:R00982|MetaCyc:AMINOBENZCOALIG-RXN|RHEA:10828|UM-BBD_reactionID:r0341 go.json 2-aminobenzoate coenzyme A ligase activity|2-aminobenzoate-CoA ligase activity|2-aminobenzoate-coenzyme A ligase activity|anthranilate--CoA ligase activity|anthranilate:CoA ligase (AMP-forming)|anthraniloyl coenzyme A synthetase activity http://purl.obolibrary.org/obo/GO_0018860 GO:0018863 biolink:MolecularActivity phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene. EC:3.3.2.-|UM-BBD_reactionID:r0496 go.json http://purl.obolibrary.org/obo/GO_0018863 GO:0018862 biolink:MolecularActivity phenylphosphate carboxylase activity Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate. EC:6.4.1.-|MetaCyc:PHENYLPCARB-RXN|UM-BBD_reactionID:r0157 go.json http://purl.obolibrary.org/obo/GO_0018862 GO:0004239 biolink:MolecularActivity initiator methionyl aminopeptidase activity Catalysis of the release of N-terminal initiator methionine from peptides. EC:3.4.11.18|MetaCyc:3.4.11.18-RXN go.json L-methionine aminopeptidase activity|MAP|methionine aminopeptidase activity|peptidase M activity http://purl.obolibrary.org/obo/GO_0004239 GO:0004238 biolink:MolecularActivity obsolete meprin A activity OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues. go.json N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity|PABA-peptide hydrolase activity|PPH|endopeptidase-2 activity|meprin|meprin A activity|meprin-a True http://purl.obolibrary.org/obo/GO_0004238 GO:0004235 biolink:MolecularActivity obsolete matrilysin activity OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I). go.json MMP|MMP 7|MMP-7|PUMP|PUMP-1 activity|PUMP-1 proteinase activity|matrilysin activity|matrin activity|matrix metalloproteinase 7 activity|matrix metalloproteinase pump 1|metalloproteinase pump-1|putative (or punctuated) metalloproteinase-1 activity|putative metalloproteinase activity|uterine metalloendopeptidase activity True http://purl.obolibrary.org/obo/GO_0004235 GO:0004234 biolink:MolecularActivity obsolete macrophage elastase activity OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin. EC:3.4.24.65|MetaCyc:3.4.24.65-RXN go.json MMP-12|human macrophage metalloelastase (HME)|macrophage elastase activity|matrix metalloproteinase 12 activity|metalloelastase activity|metalloesterase activity True http://purl.obolibrary.org/obo/GO_0004234 GO:0004237 biolink:MolecularActivity obsolete membrane dipeptidase activity OBSOLETE. Catalysis of the hydrolysis of dipeptides. EC:3.4.13.19|MetaCyc:3.4.13.19-RXN go.json DPH I activity|MDP|aminodipeptidase activity|dehydropeptidase I (DPH I)|dehydropeptidase I activity|dipeptide hydrolase|dipeptidyl hydrolase activity|glycosyl-phosphatidylinositol-anchored renal dipeptidase activity|membrane dipeptidase activity|microsomal dipeptidase activity|nonspecific dipeptidase activity|renal dipeptidase activity True http://purl.obolibrary.org/obo/GO_0004237 GO:0004231 biolink:MolecularActivity obsolete insulysin activity OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins. go.json IDE|insulin protease activity|insulin proteinase activity|insulin-degrading enzyme activity|insulin-degrading neutral proteinase activity|insulin-glucagon protease activity|insulin-specific protease activity|insulinase activity|insulysin activity|metalloinsulinase activity True http://purl.obolibrary.org/obo/GO_0004231 GO:0004230 biolink:MolecularActivity obsolete glutamyl aminopeptidase activity OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide. EC:3.4.11.7|MetaCyc:3.4.11.7-RXN go.json Ca2+-activated glutamate aminopeptidase activity|L-aspartate aminopeptidase activity|aminopeptidase A|angiotensinase A|angiotensinase A2|antigen BP-1/6C3 of mouse B lymphocytes|aspartate aminopeptidase activity|glutamyl aminopeptidase activity|glutamyl peptidase activity|membrane aminopeptidase II True http://purl.obolibrary.org/obo/GO_0004230 GO:0004232 biolink:MolecularActivity obsolete interstitial collagenase activity OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue. go.json MMP-1|interstitial collagenase activity|matrix metalloproteinase 1|vertebrate collagenase activity True http://purl.obolibrary.org/obo/GO_0004232 GO:0018879 biolink:BiologicalProcess biphenyl metabolic process The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). UM-BBD_pathwayID:bph go.json biphenyl metabolism|xenene metabolic process|xenene metabolism http://purl.obolibrary.org/obo/GO_0018879 GO:0018876 biolink:BiologicalProcess benzonitrile metabolic process The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin. UM-BBD_pathwayID:bzn go.json benzonitrile metabolism http://purl.obolibrary.org/obo/GO_0018876 GO:0018875 biolink:BiologicalProcess anaerobic benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen. MetaCyc:CENTBENZCOA-PWY|UM-BBD_pathwayID:benz go.json anaerobic benzoate metabolism http://purl.obolibrary.org/obo/GO_0018875 GO:0018878 biolink:BiologicalProcess aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen. go.json aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism http://purl.obolibrary.org/obo/GO_0018878 GO:0018877 biolink:BiologicalProcess beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. UM-BBD_pathwayID:hch go.json beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism http://purl.obolibrary.org/obo/GO_0018877 GO:0018872 biolink:BiologicalProcess arsonoacetate metabolic process The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides. UM-BBD_pathwayID:ara go.json arsonoacetate metabolism http://purl.obolibrary.org/obo/GO_0018872 GO:0018871 biolink:BiologicalProcess 1-aminocyclopropane-1-carboxylate metabolic process The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. UM-BBD_pathwayID:acp go.json 1-aminocyclopropane-1-carboxylate metabolism|ACP metabolic process|ACP metabolism http://purl.obolibrary.org/obo/GO_0018871 GO:0018874 biolink:BiologicalProcess benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. MetaCyc:P321-PWY|UM-BBD_pathwayID:benz2 go.json benzoate metabolism http://purl.obolibrary.org/obo/GO_0018874 GO:0018873 biolink:BiologicalProcess atrazine metabolic process The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide. UM-BBD_pathwayID:atr go.json atrazine metabolism http://purl.obolibrary.org/obo/GO_0018873 GO:0018870 biolink:BiologicalProcess anaerobic 2-aminobenzoate metabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen. UM-BBD_pathwayID:abz go.json anaerobic 2-aminobenzoate metabolism http://purl.obolibrary.org/obo/GO_0018870 GO:0004206 biolink:MolecularActivity obsolete caspase-10 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-10 activity True http://purl.obolibrary.org/obo/GO_0004206 GO:0004205 biolink:MolecularActivity obsolete caspase-8 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-8 activity True http://purl.obolibrary.org/obo/GO_0004205 GO:0004208 biolink:MolecularActivity obsolete caspase-3 activity OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis. go.json caspase-3 activity True http://purl.obolibrary.org/obo/GO_0004208 GO:0004207 biolink:MolecularActivity obsolete effector caspase activity OBSOLETE. (Was not defined before being made obsolete). go.json effector caspase activity True http://purl.obolibrary.org/obo/GO_0004207 GO:0004202 biolink:MolecularActivity obsolete caspase-2 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-2 activity True http://purl.obolibrary.org/obo/GO_0004202 GO:0004201 biolink:MolecularActivity obsolete caspase-1 activity OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec. go.json ICE|caspase-1 activity True http://purl.obolibrary.org/obo/GO_0004201 GO:0004204 biolink:MolecularActivity obsolete caspase-5 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-5 activity True http://purl.obolibrary.org/obo/GO_0004204 GO:0004203 biolink:MolecularActivity obsolete caspase-4 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-4 activity True http://purl.obolibrary.org/obo/GO_0004203 GO:0004200 biolink:MolecularActivity obsolete signaling (initiator) caspase activity OBSOLETE. (Was not defined before being made obsolete). go.json signaling (initiator) caspase activity|signalling (initiator) caspase activity True http://purl.obolibrary.org/obo/GO_0004200 GO:0018847 biolink:MolecularActivity alpha-pinene lyase activity Catalysis of the reaction: alpha-pinene = limonene. EC:5.5.1.-|UM-BBD_reactionID:r0712 go.json http://purl.obolibrary.org/obo/GO_0018847 GO:0018846 biolink:MolecularActivity styrene-oxide isomerase activity Catalysis of the reaction: styrene oxide = phenylacetaldehyde. EC:5.3.99.7|KEGG_REACTION:R02615|MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN|RHEA:21604|UM-BBD_reactionID:r0034 go.json SOI activity|styrene oxide isomerase activity|styrene-oxide isomerase (epoxide-cleaving) http://purl.obolibrary.org/obo/GO_0018846 GO:0018849 biolink:MolecularActivity muconate cycloisomerase activity Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate. EC:5.5.1.1|MetaCyc:MUCONATE-CYCLOISOMERASE-RXN|RHEA:30031|UM-BBD_enzymeID:e0133 go.json cis,cis-muconate cycloisomerase activity|cis,cis-muconate-lactonizing enzyme|muconate cycloisomerase I activity|muconate lactonizing enzyme I activity|muconate lactonizing enzyme activity http://purl.obolibrary.org/obo/GO_0018849 GO:0018848 biolink:MolecularActivity pinocarveol isomerase activity Catalysis of the reaction: pinocarveol = carveol. EC:5.5.1.-|UM-BBD_reactionID:r0715 go.json http://purl.obolibrary.org/obo/GO_0018848 GO:0018843 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018843 GO:0018842 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018842 GO:0018845 biolink:MolecularActivity 2-hydroxychromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate. EC:5.99.1.4|KEGG_REACTION:R05137|MetaCyc:RXNN-386|RHEA:27401|UM-BBD_reactionID:r0337 go.json http://purl.obolibrary.org/obo/GO_0018845 GO:0018844 biolink:MolecularActivity 2-hydroxytetrahydrofuran isomerase activity Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde. EC:5.3.99.-|UM-BBD_reactionID:r0019 go.json http://purl.obolibrary.org/obo/GO_0018844 GO:0018841 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018841 GO:0018840 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018840 GO:0004209 biolink:MolecularActivity obsolete caspase-6 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-6 activity True http://purl.obolibrary.org/obo/GO_0004209 GO:0004217 biolink:MolecularActivity obsolete cathepsin L activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. go.json Aldrichina grahami cysteine proteinase|cathepsin L activity True http://purl.obolibrary.org/obo/GO_0004217 GO:0004216 biolink:MolecularActivity obsolete cathepsin K activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. go.json cathepsin K activity|cathepsin O activity|cathepsin O2 activity|cathepsin X activity True http://purl.obolibrary.org/obo/GO_0004216 GO:0004219 biolink:MolecularActivity obsolete pyroglutamyl-peptidase I activity OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide. EC:3.4.19.3|MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN go.json 5-oxoprolyl-peptidase activity|L-pyroglutamyl peptide hydrolase activity|L-pyrrolidonecarboxylate peptidase activity|PYRase activity|pyroglutamate aminopeptidase activity|pyroglutamidase activity|pyroglutamyl aminopeptidase activity|pyroglutamyl-peptidase I activity|pyrrolidone carboxyl peptidase activity|pyrrolidone-carboxyl peptidase activity|pyrrolidone-carboxylate peptidase activity|pyrrolidonecarboxylyl peptidase activity|pyrrolidonyl peptidase activity True http://purl.obolibrary.org/obo/GO_0004219 GO:0004218 biolink:MolecularActivity obsolete cathepsin S activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds. go.json cathepsin S activity True http://purl.obolibrary.org/obo/GO_0004218 GO:0004213 biolink:MolecularActivity obsolete cathepsin B activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. go.json cathepsin B activity|cathepsin B1 activity|cathepsin II True http://purl.obolibrary.org/obo/GO_0004213 GO:0004212 biolink:MolecularActivity obsolete lysosomal cysteine-type endopeptidase OBSOLETE. (Was not defined before being made obsolete). go.json lysosomal cysteine-type endopeptidase True http://purl.obolibrary.org/obo/GO_0004212 GO:0004215 biolink:MolecularActivity obsolete cathepsin H activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase. go.json N-benzoylarginine-beta-naphthylamide hydrolase activity|aleurain activity|benzoylarginine-naphthylamide (BANA) hydrolase activity|cathepsin B3 activity|cathepsin BA activity|cathepsin Ba|cathepsin H activity True http://purl.obolibrary.org/obo/GO_0004215 GO:0004214 biolink:MolecularActivity obsolete dipeptidyl-peptidase I activity OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro. EC:3.4.14.1|MetaCyc:3.4.14.1-RXN go.json DAP I|cathepsin C activity|cathepsin J activity|dipeptide arylamidase I|dipeptidyl aminopeptidase I activity|dipeptidyl transferase activity|dipeptidyl-peptidase I activity True http://purl.obolibrary.org/obo/GO_0004214 GO:0004211 biolink:MolecularActivity obsolete caspase-9 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-9 activity True http://purl.obolibrary.org/obo/GO_0004211 GO:0004210 biolink:MolecularActivity obsolete caspase-7 activity OBSOLETE. (Was not defined before being made obsolete). go.json caspase-7 activity True http://purl.obolibrary.org/obo/GO_0004210 GO:0018858 biolink:MolecularActivity benzoate-CoA ligase activity Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. EC:6.2.1.25|KEGG_REACTION:R01422|MetaCyc:BENZOATE--COA-LIGASE-RXN|RHEA:10132|UM-BBD_reactionID:r0189 go.json benzoate-coenzyme A ligase activity|benzoate:CoA ligase (AMP-forming)|benzoyl CoA synthetase (AMP forming)|benzoyl-coenzyme A synthetase activity http://purl.obolibrary.org/obo/GO_0018858 GO:0018857 biolink:MolecularActivity 2,4-dichlorobenzoate-CoA ligase activity Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA. UM-BBD_reactionID:r0137 go.json http://purl.obolibrary.org/obo/GO_0018857 GO:0018859 biolink:MolecularActivity 4-hydroxybenzoate-CoA ligase activity Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA. EC:6.2.1.27|KEGG_REACTION:R01300|MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN|RHEA:23116|UM-BBD_reactionID:r0156 go.json 4-hydroxybenzoate-CoA synthetase activity|4-hydroxybenzoate-coenzyme A ligase (AMP-forming)|4-hydroxybenzoate:CoA ligase (AMP-forming)|4-hydroxybenzoyl coenzyme A synthetase activity|4-hydroxybenzoyl-CoA ligase activity http://purl.obolibrary.org/obo/GO_0018859 GO:0018854 biolink:MolecularActivity 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. UM-BBD_reactionID:r0737 go.json http://purl.obolibrary.org/obo/GO_0018854 GO:0018853 biolink:MolecularActivity obsolete perillyl-CoA synthetase activity OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA. EC:6.2.1.-|UM-BBD_reactionID:r0731 go.json perillyl-CoA synthetase activity True http://purl.obolibrary.org/obo/GO_0018853 GO:0018856 biolink:MolecularActivity benzoyl acetate-CoA ligase activity Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA. KEGG_REACTION:R05452|SABIO-RK:5058|UM-BBD_reactionID:r0242 go.json http://purl.obolibrary.org/obo/GO_0018856 GO:0018855 biolink:MolecularActivity 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA. EC:6.2.1.38|RHEA:33419|UM-BBD_reactionID:r0429 go.json http://purl.obolibrary.org/obo/GO_0018855 GO:0018850 biolink:MolecularActivity chloromuconate cycloisomerase activity Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. EC:5.5.1.7|RHEA:11032|UM-BBD_enzymeID:e0065 go.json 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)|muconate cycloisomerase II activity http://purl.obolibrary.org/obo/GO_0018850 GO:0018852 biolink:MolecularActivity dichloromuconate cycloisomerase activity Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate. EC:5.5.1.11|MetaCyc:RXN-9856|RHEA:17437|UM-BBD_reactionID:r0277 go.json 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) http://purl.obolibrary.org/obo/GO_0018852 GO:0018851 biolink:MolecularActivity alpha-pinene-oxide decyclase activity Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal. EC:5.5.1.10|KEGG_REACTION:R04040|MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN|RHEA:16693|UM-BBD_reactionID:r0743 go.json alpha-pinene oxide lyase activity|alpha-pinene-oxide lyase (decyclizing) http://purl.obolibrary.org/obo/GO_0018851 GO:0018829 biolink:MolecularActivity 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. EC:4.5.1.-|UM-BBD_reactionID:r0513 go.json DDD dehydrochlorinase activity http://purl.obolibrary.org/obo/GO_0018829 GO:0018828 biolink:MolecularActivity halohydrin hydrogen-halide-lyase A activity Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane. UM-BBD_enzymeID:e0048 go.json http://purl.obolibrary.org/obo/GO_0018828 GO:0018825 biolink:MolecularActivity triethanolamine lyase activity Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde. UM-BBD_enzymeID:e0421 go.json http://purl.obolibrary.org/obo/GO_0018825 GO:0018824 biolink:MolecularActivity (hydroxyamino)benzene mutase activity Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol. MetaCyc:5.4.4.1-RXN|RHEA:19245|UM-BBD_reactionID:r0304 go.json (hydroxyamino)benzene hydroxymutase activity|HAB mutase activity|hydroxylaminobenzene hydroxymutase activity|hydroxylaminobenzene mutase activity http://purl.obolibrary.org/obo/GO_0018824 GO:0018827 biolink:MolecularActivity 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU. EC:4.5.1.-|UM-BBD_reactionID:r0515 go.json DDMS dehydrochlorinase activity http://purl.obolibrary.org/obo/GO_0018827 GO:0018826 biolink:MolecularActivity methionine gamma-lyase activity Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate. EC:4.4.1.11|MetaCyc:METHIONINE-GAMMA-LYASE-RXN|RHEA:23800|UM-BBD_reactionID:r0432 go.json L-methioninase activity|L-methionine gamma-lyase activity|L-methionine methanethiol-lyase (deaminating)|L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)|methioninase activity|methionine dethiomethylase activity|methionine lyase activity http://purl.obolibrary.org/obo/GO_0018826 GO:0018821 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018821 GO:0018820 biolink:MolecularActivity cyanamide hydratase activity Catalysis of the reaction: urea = cyanamide + H2O. EC:4.2.1.69|KEGG_REACTION:R00778|MetaCyc:CYANAMIDE-HYDRATASE-RXN|RHEA:23056|UM-BBD_reactionID:r0668 go.json urea hydro-lyase (cyanamide-forming)|urea hydro-lyase activity http://purl.obolibrary.org/obo/GO_0018820 GO:0018823 biolink:MolecularActivity cyclohexa-1,5-dienecarbonyl-CoA hydratase activity Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-enecarbonyl-CoA. EC:4.2.1.100|KEGG_REACTION:R05597|MetaCyc:4.2.1.100-RXN|RHEA:21856|UM-BBD_reactionID:r0203 go.json 6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)|cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity|cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity|cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity|cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity|dienoyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0018823 GO:0018822 biolink:MolecularActivity nitrile hydratase activity Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. EC:4.2.1.84|MetaCyc:NITRILE-HYDRATASE-RXN|RHEA:12673|UM-BBD_enzymeID:e0067 go.json 3-cyanopyridine hydratase activity|H-NHase activity|L-NHase activity|NHase activity|acrylonitrile hydratase activity|aliphatic nitrile hydratase activity|aliphatic-amide hydro-lyase (nitrile-forming)|nitrile hydro-lyase activity http://purl.obolibrary.org/obo/GO_0018822 GO:0018839 biolink:MolecularActivity cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. EC:5.2.1.-|UM-BBD_reactionID:r0163 go.json http://purl.obolibrary.org/obo/GO_0018839 GO:0018836 biolink:MolecularActivity alkylmercury lyase activity Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+. EC:4.99.1.2|MetaCyc:ALKYLMERCURY-LYASE-RXN|RHEA:18777|UM-BBD_enzymeID:e0055 go.json alkylmercury mercuric-lyase (alkane-forming)|alkylmercury mercuric-lyase activity|organomercurial lyase activity|organomercury lyase activity http://purl.obolibrary.org/obo/GO_0018836 GO:0018835 biolink:MolecularActivity carbon phosphorus lyase activity Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate). EC:4.7.1.- go.json http://purl.obolibrary.org/obo/GO_0018835 GO:0018838 biolink:MolecularActivity mandelate racemase activity Catalysis of the reaction: (S)-mandelate = (R)-mandelate. EC:5.1.2.2|MetaCyc:MANDELATE-RACEMASE-RXN|RHEA:13945|UM-BBD_reactionID:r0091 go.json http://purl.obolibrary.org/obo/GO_0018838 GO:0018837 biolink:MolecularActivity 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate. UM-BBD_reactionID:r0502 go.json http://purl.obolibrary.org/obo/GO_0018837 GO:0018832 biolink:MolecularActivity halohydrin hydrogen-halide-lyase B activity Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane. UM-BBD_enzymeID:e0050 go.json http://purl.obolibrary.org/obo/GO_0018832 GO:0018831 biolink:MolecularActivity 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone. EC:4.5.1.-|UM-BBD_reactionID:r0666 go.json http://purl.obolibrary.org/obo/GO_0018831 GO:0018834 biolink:MolecularActivity dichloromethane dehalogenase activity Catalysis of the reaction: dichloromethane + H2O = 2 chloride + formaldehyde + 2 H+. EC:4.5.1.3|KEGG_REACTION:R00603|MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN|RHEA:15397|UM-BBD_reactionID:r0188 go.json dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)|dichloromethane chloride-lyase (chloride-hydrolysing) http://purl.obolibrary.org/obo/GO_0018834 GO:0018833 biolink:MolecularActivity DDT-dehydrochlorinase activity Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H+. EC:4.5.1.1|KEGG_REACTION:R04522|MetaCyc:DDT-DEHYDROCHLORINASE-RXN|RHEA:19217|UM-BBD_reactionID:r0439 go.json 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]|1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity|DDT dehydrochlorinase activity|DDT-as|DDT-ase activity|DDTase activity http://purl.obolibrary.org/obo/GO_0018833 GO:0018830 biolink:MolecularActivity gamma-hexachlorocyclohexane dehydrochlorinase activity Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene. EC:4.5.1.-|UM-BBD_enzymeID:e0359 go.json http://purl.obolibrary.org/obo/GO_0018830 GO:0047504 biolink:MolecularActivity (-)-menthol dehydrogenase activity Catalysis of the reaction: (-)-menthol + NADP+ = (2S,5R)-menthone + H+ + NADPH. EC:1.1.1.207|KEGG_REACTION:R02177|MetaCyc:--MENTHOL-DEHYDROGENASE-RXN|RHEA:13917|UM-BBD_reactionID:r1182 go.json (-)-menthol:NADP+ oxidoreductase activity|monoterpenoid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047504 GO:0047503 biolink:MolecularActivity (-)-borneol dehydrogenase activity Catalysis of the reaction: (-)-borneol + NAD+ = (1S,4S)-camphor + H+ + NADH. EC:1.1.1.227|KEGG_REACTION:R02945|MetaCyc:--BORNEOL-DEHYDROGENASE-RXN|RHEA:22128 go.json (-)-borneol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047503 GO:0047502 biolink:MolecularActivity (+)-sabinol dehydrogenase activity Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (1S,5S)-sabinone + H+ + NADH. EC:1.1.1.228|KEGG_REACTION:R03745|MetaCyc:+-SABINOL-DEHYDROGENASE-RXN|RHEA:18329 go.json (+)-cis-sabinol dehydrogenase activity|(+)-cis-sabinol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047502 GO:0047501 biolink:MolecularActivity (+)-neomenthol dehydrogenase activity Catalysis of the reaction: (+)-neomenthol + NADP+ = (2S,5R)-menthone + H+ + NADPH. EC:1.1.1.208|KEGG_REACTION:R02548|MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN|RHEA:23812 go.json (+)-neomenthol:NADP+ oxidoreductase activity|monoterpenoid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047501 GO:0047500 biolink:MolecularActivity (+)-borneol dehydrogenase activity Catalysis of the reaction: (+)-borneol + NAD+ = (1R, 4R)-camphor + H+ + NADH. EC:1.1.1.198|KEGG_REACTION:R02944|MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN|RHEA:17329 go.json (+)-borneol:NAD+ oxidoreductase activity|bicyclic monoterpenol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047500 GO:0047509 biolink:MolecularActivity (R)-dehydropantoate dehydrogenase activity Catalysis of the reaction: (R)-4-dehydropantoate + H2O + NAD+ = (R)-3,3-dimethylmalate + 2 H+ + NADH. EC:1.2.1.33|KEGG_REACTION:R03198|MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN|RHEA:19349 go.json (R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity|D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity|D-aldopantoate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047509 GO:0047508 biolink:MolecularActivity (R)-2-methylmalate dehydratase activity Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H2O. EC:4.2.1.35|KEGG_REACTION:R03896|MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN|RHEA:22332 go.json (-)-citramalate hydro-lyase activity|(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)|(R)-2-methylmalate hydro-lyase activity|citraconase activity|citraconate hydratase activity|citramalate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047508 GO:0047507 biolink:MolecularActivity (deoxy)nucleoside-phosphate kinase activity Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate. EC:2.7.4.13|MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN|RHEA:11216 go.json ATP:deoxynucleoside-phosphate phosphotransferase activity|deoxynucleoside monophosphate kinase activity|deoxynucleoside-5'-monophosphate kinase activity|deoxyribonucleoside monophosphokinase activity http://purl.obolibrary.org/obo/GO_0047507 GO:0047506 biolink:MolecularActivity (deoxy)adenylate kinase activity Catalysis of the reaction: ATP + dAMP = ADP + dADP. EC:2.7.4.11|MetaCyc:DEOXYADENYLATE-KINASE-RXN|RHEA:23100 go.json ATP:(d)AMP phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047506 GO:0047505 biolink:MolecularActivity (-)-menthol monooxygenase activity Catalysis of the reaction: (-)-menthol + H+ + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP+. EC:1.14.13.46|KEGG_REACTION:R02178|MetaCyc:--MENTHOL-MONOOXYGENASE-RXN|RHEA:11648 go.json (-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)|l-menthol monooxygenase activity http://purl.obolibrary.org/obo/GO_0047505 GO:0047515 biolink:MolecularActivity 1,3-beta-oligoglucan phosphorylase activity Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate. EC:2.4.1.30|MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN|RHEA:16041 go.json 1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity|beta-1,3-oligoglucan phosphorylase activity|beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity http://purl.obolibrary.org/obo/GO_0047515 GO:0047514 biolink:MolecularActivity 1,3-beta-D-glucan phosphorylase activity Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin. EC:2.4.1.97|MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN go.json 1,3-beta-D-glucan:orthophosphate glucosyltransferase activity|1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity|1,3-beta-glucan phosphorylase activity|laminarin phosphorylase activity|laminarin phosphoryltransferase activity http://purl.obolibrary.org/obo/GO_0047514 GO:0047513 biolink:MolecularActivity 1,2-alpha-L-fucosidase activity Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside. EC:3.2.1.63|MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN|RHEA:10816 go.json 2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity|almond emulsin fucosidase II activity|almond emulsin fucosidase activity|alpha-(1->2)-L-fucosidase activity http://purl.obolibrary.org/obo/GO_0047513 GO:0047512 biolink:MolecularActivity (S,S)-butanediol dehydrogenase activity Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + H+ + NADH. EC:1.1.1.76|KEGG_REACTION:R03707|MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN|RHEA:12184 go.json (S,S)-butane-2,3-diol:NAD+ oxidoreductase activity|L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)|L-BDH|L-butanediol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047512 GO:0047511 biolink:MolecularActivity (S)-methylmalonyl-CoA hydrolase activity Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = CoA + H+ + methylmalonate. EC:3.1.2.17|KEGG_REACTION:R02764|MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN|RHEA:17345 go.json D-methylmalonyl-coenzyme A hydrolase activity http://purl.obolibrary.org/obo/GO_0047511 GO:0047510 biolink:MolecularActivity (S)-2-methylmalate dehydratase activity Catalysis of the reaction: S-citramalate = H2O + mesaconate. EC:4.2.1.34|KEGG_REACTION:R03693|MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN|RHEA:13529 go.json (+)-citramalate hydro-lyase activity|(+)-citramalic hydro-lyase activity|(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)|(S)-2-methylmalate hydro-lyase activity|L-citramalate hydrolase activity|citramalate dehydratase activity|mesaconase activity|mesaconate hydratase activity|mesaconate mesaconase activity http://purl.obolibrary.org/obo/GO_0047510 GO:0047519 biolink:MolecularActivity quinate dehydrogenase (quinone) activity Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol. EC:1.1.5.8|KEGG_REACTION:R01873|MetaCyc:1.1.99.25-RXN|RHEA:23672 go.json NAD(P)-independent quinate dehydrogenase activity|quinate:pyrroloquinoline-quinone 5-oxidoreductase activity|quinate:quinone 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047519 GO:0047518 biolink:MolecularActivity 1-methyladenosine nucleosidase activity Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + ribofuranose. EC:3.2.2.13|KEGG_REACTION:R03885|MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN|RHEA:12865 go.json 1-methyladenosine hydrolase activity|1-methyladenosine ribohydrolase activity http://purl.obolibrary.org/obo/GO_0047518 GO:0047517 biolink:MolecularActivity 1,4-beta-D-xylan synthase activity Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1). EC:2.4.2.24|MetaCyc:RXN-9104|RHEA:15289 go.json 1,4-beta-xylan synthase activity|UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity|uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity|xylan synthase activity|xylan synthetase activity http://purl.obolibrary.org/obo/GO_0047517 GO:0047516 biolink:MolecularActivity 1,3-propanediol dehydrogenase activity Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. EC:1.1.1.202|MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN|RHEA:23188 go.json 1,3-PD:NAD+ oxidoreductase activity|1,3-propanediol oxidoreductase activity|1,3-propanediol:NAD+ oxidoreductase activity|3-hydroxypropionaldehyde reductase activity|propane-1,3-diol:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047516 GO:0047526 biolink:MolecularActivity 2'-hydroxyisoflavone reductase activity Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+. EC:1.3.1.45|MetaCyc:RXN-3562|RHEA:22560 go.json 2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity|NADPH:2'-hydroxyisoflavone oxidoreductase activity|isoflavone reductase activity|vestitone:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047526 GO:0047525 biolink:MolecularActivity 2'-hydroxydaidzein reductase activity Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+. EC:1.3.1.51|MetaCyc:RXN-4502|RHEA:17145 go.json 2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity|2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity|2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity|HDR activity|NADPH:2'-hydroxydaidzein oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047525 GO:0047524 biolink:MolecularActivity 16-hydroxysteroid epimerase activity Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid. EC:5.1.99.2|MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN|RHEA:15829 go.json 16-hydroxysteroid 16-epimerase activity http://purl.obolibrary.org/obo/GO_0047524 GO:0047523 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047523 GO:0047522 biolink:MolecularActivity 15-oxoprostaglandin 13-oxidase activity Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+. EC:1.3.1.48|KEGG_REACTION:R04556|KEGG_REACTION:R04557|MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN go.json (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047522 GO:0047521 biolink:MolecularActivity 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH. EC:1.1.1.238|KEGG_REACTION:R03495|MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN|RHEA:21424 go.json 12-beta-hydroxysteroid dehydrogenase activity|12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|12beta-hydroxysteroid dehydrogenase activity|12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047521 GO:0047520 biolink:MolecularActivity 11-cis-retinyl-palmitate hydrolase activity Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + H+ + palmitate. EC:3.1.1.63|KEGG_REACTION:R03049|MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN|RHEA:19697|Reactome:R-HSA-2465941 go.json 11-cis-retinol palmitate esterase activity|11-cis-retinyl-palmitate acylhydrolase activity|RPH http://purl.obolibrary.org/obo/GO_0047520 GO:0047529 biolink:MolecularActivity 2,3-dimethylmalate lyase activity Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate. EC:4.1.3.32|KEGG_REACTION:R01355|MetaCyc:23-DIMETHYLMALATE-LYASE-RXN|RHEA:10472 go.json (2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)|(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity|2,3-dimethylmalate pyruvate-lyase activity http://purl.obolibrary.org/obo/GO_0047529 GO:0047528 biolink:MolecularActivity 2,3-dihydroxyindole 2,3-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2 + H+. EC:1.13.11.23|KEGG_REACTION:R00983|MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN|RHEA:19445 go.json 2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity http://purl.obolibrary.org/obo/GO_0047528 GO:0047527 biolink:MolecularActivity 2,3-dihydroxybenzoate-serine ligase activity Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. EC:6.3.2.14|MetaCyc:ENTMULTI-RXN|RHEA:30571 go.json 2,3-dihydroxybenzoate:L-serine ligase activity|2,3-dihydroxybenzoylserine synthetase activity|N-(2,3-dihydroxybenzoyl)-serine synthetase activity http://purl.obolibrary.org/obo/GO_0047527 GO:0072452 biolink:BiologicalProcess response to G2 transition size control checkpoint signaling A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling. go.json G2/M transition size control checkpoint effector process|response to G2/M transition size control checkpoint signaling|response to mitotic cell cycle G2/M transition size control checkpoint signaling|response to signal involved in G2/M transition size control checkpoint http://purl.obolibrary.org/obo/GO_0072452 GO:0106430 biolink:MolecularActivity dihydroorotate dehydrogenase (quinone) activity (S)-dihydroorotate + a quinone = orotate + a quinol. EC:1.3.5.2|RHEA:30187 go.json http://purl.obolibrary.org/obo/GO_0106430 GO:0047496 biolink:BiologicalProcess vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. go.json microtubule-based vesicle localization http://purl.obolibrary.org/obo/GO_0047496 GO:0072451 biolink:BiologicalProcess obsolete detection of stimulus involved in G2 cell size control checkpoint OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint. go.json G2/M transition size control checkpoint sensor mechanism|G2/M transition size control checkpoint sensor process|detection of stimulus involved in G2/M transition size control checkpoint|detection of stimulus involved in mitotic cell cycle G2/M transition size control checkpoint|sensing involved in G2/M transition size control checkpoint True http://purl.obolibrary.org/obo/GO_0072451 GO:0047495 biolink:MolecularActivity membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another. EC:2.7.8.21|MetaCyc:PGLYCEROLTRANSII-RXN go.json membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity|periplasmic phosphoglycerotransferase activity|phosphoglycerol cyclase activity http://purl.obolibrary.org/obo/GO_0047495 GO:0047494 biolink:MolecularActivity serine-phosphoethanolamine synthase activity Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H+. EC:2.7.8.4|KEGG_REACTION:R02563|MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN|RHEA:22656 go.json CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity|serine ethanolamine phosphate synthetase activity|serine ethanolamine phosphodiester synthase activity|serine ethanolaminephosphotransferase activity|serine-phosphinico-ethanolamine synthase activity|serinephosphoethanolamine synthase activity http://purl.obolibrary.org/obo/GO_0047494 GO:0072450 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072450 GO:0047493 biolink:MolecularActivity ceramide cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin. EC:2.7.8.3|KEGG_REACTION:R01891|MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN|RHEA:16273 go.json CDP-choline:N-acylsphingosine cholinephosphotransferase activity|phosphorylcholine-ceramide transferase activity http://purl.obolibrary.org/obo/GO_0047493 GO:0106434 biolink:BiologicalProcess retinal isomerization The reactions involved in isomerization of all trans to all cis retnal. go.json http://purl.obolibrary.org/obo/GO_0106434 GO:0047492 biolink:MolecularActivity xanthan lyase activity Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain. EC:4.2.2.12|MetaCyc:4.2.2.12-RXN go.json http://purl.obolibrary.org/obo/GO_0047492 GO:0106433 biolink:MolecularActivity O6-methyl-dGTP hydrolase activity Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+. RHEA:67600 go.json http://purl.obolibrary.org/obo/GO_0106433 GO:0047491 biolink:MolecularActivity poly(alpha-L-guluronate) lyase activity Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends. EC:4.2.2.11|MetaCyc:4.2.2.11-RXN go.json L-guluronan lyase activity|L-guluronate lyase activity|alginase II activity|guluronate lyase activity|poly(alpha-L-1,4-guluronide) exo-lyase activity|poly-alpha-L-guluronate lyase activity|polyguluronate-specific alginate lyase activity http://purl.obolibrary.org/obo/GO_0047491 GO:0106432 biolink:MolecularActivity queuosine nucleosidase activity Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose. go.json queuosine nucleoside glycosylase|tRNA queuosine nucleoside glycosylase http://purl.obolibrary.org/obo/GO_0106432 GO:0047490 biolink:MolecularActivity pectin lyase activity Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends. EC:4.2.2.10|MetaCyc:RXN-19781 go.json (1->4)-6-O-methyl-alpha-D-galacturonan lyase activity|PL activity|PMGL activity|PNL activity|endo-pectin lyase activity|pectin methyltranseliminase activity|pectin trans-eliminase activity|pectolyase activity|polymethylgalacturonic transeliminase activity http://purl.obolibrary.org/obo/GO_0047490 GO:0106431 biolink:MolecularActivity N6-methyl-(d)ATP hydrolase activity Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+. go.json http://purl.obolibrary.org/obo/GO_0106431 GO:0106438 biolink:MolecularActivity protein-glutamic acid ligase activity, elongating Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate. Rhea:60148 go.json http://purl.obolibrary.org/obo/GO_0106438 GO:0106437 biolink:MolecularActivity protein-glutamic acid ligase activity, initiating Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate. Rhea:60144 go.json http://purl.obolibrary.org/obo/GO_0106437 GO:0106436 biolink:MolecularActivity glutathione-dependent sulfide quinone oxidoreductase activity Catalysis of the reaction: a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione. EC:1.8.5.8|RHEA:55156 go.json eukaryotic sulfide quinone oxidoreductase http://purl.obolibrary.org/obo/GO_0106436 GO:0106435 biolink:MolecularActivity carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H(+). EC:3.1.1.1|MetaCyc:CARBOXYLESTERASE-RXN|RHEA:21164|Reactome:R-HSA-9619024|Reactome:R-HSA-9727567|Reactome:R-HSA-9749647 go.json B-esterase activity|ali-esterase activity|alpha-carboxylesterase activity|cocaine esterase|nonspecific carboxylesterase activity|procaine esterase|serine esterase activity|triacetin esterase|vitamin A esterase http://purl.obolibrary.org/obo/GO_0106435 GO:0047499 biolink:MolecularActivity calcium-independent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. Reactome:R-HSA-8952251 go.json calcium-independent cytosolic phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0047499 goslim_chembl GO:0047498 biolink:MolecularActivity calcium-dependent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. Reactome:R-HSA-111883 go.json calcium-dependent cytosolic phospholipase A2 activity|calcium-dependent secreted phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0047498 GO:0047497 biolink:BiologicalProcess mitochondrion transport along microtubule The directed movement of a mitochondrion along a microtubule, mediated by motor proteins. go.json mitochondrial migration along microtubule|mitochondrial transport along microtubule http://purl.obolibrary.org/obo/GO_0047497 GO:0106439 biolink:MolecularActivity L-lysine:L-arginine antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out). RHEA:70827 go.json http://purl.obolibrary.org/obo/GO_0106439 GO:0072459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072459 GO:0072458 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072458 GO:0072457 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072457 GO:0072456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072456 GO:0072455 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072455 GO:0072454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072454 GO:0072453 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072453 GO:0072441 biolink:BiologicalProcess response to meiotic DNA replication checkpoint signaling A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling. go.json meiotic DNA replication checkpoint effector process|response to signal involved in meiotic DNA replication checkpoint http://purl.obolibrary.org/obo/GO_0072441 GO:0072440 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072440 GO:0072449 biolink:BiologicalProcess response to G1 cell size control checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling. go.json mitotic cell cycle G1/S transition size control checkpoint effector process|response to signal involved in mitotic cell cycle G1/S transition size control checkpoint http://purl.obolibrary.org/obo/GO_0072449 GO:0072448 biolink:BiologicalProcess obsolete detection of stimulus involved in G1 cell size control checkpoint OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition size control checkpoint. go.json detection of stimulus involved in mitotic cell cycle G1/S transition size control checkpoint|mitotic cell cycle G1/S transition size control checkpoint sensor mechanism|mitotic cell cycle G1/S transition size control checkpoint sensor process|sensing involved in mitotic cell cycle G1/S transition size control checkpoint True http://purl.obolibrary.org/obo/GO_0072448 GO:0072447 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072447 GO:0072446 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072446 GO:0072445 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072445 GO:0072444 biolink:BiologicalProcess response to mitotic DNA replication checkpoint signaling A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling. go.json S-M checkpoint effector process|mitotic DNA replication checkpoint effector process|response to S-M checkpoint signaling|response to signal involved in S-M checkpoint|response to signal involved in mitotic DNA replication checkpoint http://purl.obolibrary.org/obo/GO_0072444 GO:0072443 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072443 GO:0072442 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic DNA replication checkpoint OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint. go.json S-M checkpoint sensor mechanism|S-M checkpoint sensor process|detection of stimulus involved in S-M checkpoint|mitotic DNA replication checkpoint sensor mechanism|mitotic DNA replication checkpoint sensor process|sensing involved in S-M checkpoint|sensing involved in mitotic DNA replication checkpoint True http://purl.obolibrary.org/obo/GO_0072442 GO:0072474 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072474 GO:0072473 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072473 GO:0072472 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072472 GO:0072471 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072471 GO:0072470 biolink:BiologicalProcess response to cell size control checkpoint signaling A process that occurs in response to signals generated as a result of cell size control checkpoint signaling. go.json cell size control checkpoint effector process|response to mitotic cell cycle cell size control checkpoint signaling|response to signal involved in cell size control checkpoint http://purl.obolibrary.org/obo/GO_0072470 GO:0072479 biolink:BiologicalProcess response to mitotic cell cycle spindle assembly checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling. go.json mitotic cell cycle spindle assembly checkpoint effector process|response to Dma1-dependent checkpoint signaling|response to Dma1-dependent checkpoint signalling|response to signal involved in mitotic cell cycle spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_0072479 GO:0072478 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic spindle assembly checkpoint OBSOLETE. The series of events in which information about whether the spindle is correctly assembled, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle assembly checkpoint. go.json detection of stimulus involved in Dma1-dependent checkpoint|detection of stimulus involved in SAC-independent checkpoint|detection of stimulus involved in mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle spindle assembly checkpoint sensor mechanism|mitotic cell cycle spindle assembly checkpoint sensor process|perception of stimulus involved in DMA1-dependent checkpoint|perception of stimulus involved in SAC-independent checkpoint|sensing involved in mitotic cell cycle spindle assembly checkpoint|stimulus detection involved in DMA1-dependent checkpoint|stimulus detection involved in SAC-independent checkpoint|stimulus sensing involved in DMA1-dependent checkpoint|stimulus sensing involved in SAC-independent checkpoint True http://purl.obolibrary.org/obo/GO_0072478 GO:0072477 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072477 GO:0072476 biolink:BiologicalProcess response to mitotic spindle checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling. go.json mitotic cell cycle spindle checkpoint effector process|response to mitotic cell cycle spindle checkpoint signaling|response to signal involved in mitotic cell cycle spindle checkpoint http://purl.obolibrary.org/obo/GO_0072476 GO:0072475 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic spindle checkpoint OBSOLETE. The series of events in which information about whether the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle checkpoint. go.json detection of stimulus involved in mitotic cell cycle spindle checkpoint|mitotic cell cycle spindle checkpoint sensor mechanism|mitotic cell cycle spindle checkpoint sensor process|sensing involved in mitotic cell cycle spindle checkpoint True http://purl.obolibrary.org/obo/GO_0072475 GO:0072463 biolink:BiologicalProcess obsolete detection of stimulus involved in meiotic spindle assembly checkpoint OBSOLETE. The series of events in which information about whether spindle is correctly assembled and chromosomes are attached to the spindle is received and converted into a molecular signal, contributing to a meiotic spindle assembly checkpoint. go.json meiotic spindle assembly checkpoint sensor mechanism|meiotic spindle assembly checkpoint sensor process|sensing involved in meiotic spindle assembly checkpoint True http://purl.obolibrary.org/obo/GO_0072463 GO:0072462 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072462 GO:0072461 biolink:BiologicalProcess response to meiotic recombination checkpoint signaling A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling. go.json meiotic recombination checkpoint effector process|response to signal involved in meiotic recombination checkpoint http://purl.obolibrary.org/obo/GO_0072461 GO:0072460 biolink:BiologicalProcess obsolete detection of stimulus involved in meiotic recombination checkpoint OBSOLETE. The series of events in which information about whether recombination is complete is received and converted into a molecular signal, contributing to a meiotic recombination checkpoint. go.json meiotic recombination checkpoint sensor mechanism|meiotic recombination checkpoint sensor process|sensing involved in meiotic recombination checkpoint True http://purl.obolibrary.org/obo/GO_0072460 GO:0072469 biolink:BiologicalProcess obsolete detection of stimulus involved in cell size control checkpoint OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint. go.json cell size control checkpoint sensor mechanism|cell size control checkpoint sensor process|detection of stimulus involved in mitotic cell cycle cell size control checkpoint|sensing involved in cell size control checkpoint True http://purl.obolibrary.org/obo/GO_0072469 GO:0072468 biolink:BiologicalProcess obsolete signal transduction involved in cell shape checkpoint OBSOLETE. A signal transduction process that contributes to a cell shape checkpoint. go.json True http://purl.obolibrary.org/obo/GO_0072468 GO:0072467 biolink:BiologicalProcess obsolete response to cell shape checkpoint signaling OBSOLETE. A process that occurs in response to signals generated as a result of cell shape checkpoint signaling. go.json cell shape checkpoint effector process|response to signal involved in cell shape checkpoint True http://purl.obolibrary.org/obo/GO_0072467 GO:0072466 biolink:BiologicalProcess obsolete detection of stimulus involved in cell shape checkpoint OBSOLETE. The series of events in which information about aspects of cell polarity control is received and converted into a molecular signal, contributing to a cell shape checkpoint. go.json cell shape checkpoint sensor mechanism|cell shape checkpoint sensor process|sensing involved in cell shape checkpoint True http://purl.obolibrary.org/obo/GO_0072466 GO:0072465 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072465 GO:0072464 biolink:BiologicalProcess response to meiotic spindle assembly checkpoint signaling A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling. go.json meiotic spindle assembly checkpoint effector process|response to signal involved in meiotic spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_0072464 GO:0072496 biolink:MolecularActivity Pup transferase activity Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages. go.json Pup conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0072496 GO:0072495 biolink:CellularComponent host cell Cajal body A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction. go.json coiled body of host|host cell coiled body http://purl.obolibrary.org/obo/GO_0072495 GO:0072494 biolink:CellularComponent host multivesicular body A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm. go.json host cell multivesicular body http://purl.obolibrary.org/obo/GO_0072494 GO:0072493 biolink:CellularComponent host cell endosome lumen The volume enclosed by the membranes of the host cell endosome. go.json host endosome lumen http://purl.obolibrary.org/obo/GO_0072493 GO:0072492 biolink:CellularComponent host cell mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope. go.json http://purl.obolibrary.org/obo/GO_0072492 GO:0072491 biolink:BiologicalProcess toluene-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives. go.json toluene and derivative catabolic process|toluene-containing compound breakdown|toluene-containing compound catabolism|toluene-containing compound degradation http://purl.obolibrary.org/obo/GO_0072491 GO:0072490 biolink:BiologicalProcess toluene-containing compound metabolic process The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives. go.json toluene and derivative metabolic process|toluene-containing compound metabolism http://purl.obolibrary.org/obo/GO_0072490 GO:0072499 biolink:BiologicalProcess photoreceptor cell axon guidance The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues. go.json photoreceptor cell axon pathfinding http://purl.obolibrary.org/obo/GO_0072499 GO:0072498 biolink:BiologicalProcess embryonic skeletal joint development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. go.json http://purl.obolibrary.org/obo/GO_0072498 GO:0072497 biolink:BiologicalProcess mesenchymal stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072497 GO:0072485 biolink:BiologicalProcess response to spindle assembly checkpoint signaling A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling. go.json response to signal involved in spindle assembly checkpoint|spindle assembly checkpoint effector process http://purl.obolibrary.org/obo/GO_0072485 GO:0072484 biolink:BiologicalProcess obsolete detection of stimulus involved in spindle assembly checkpoint OBSOLETE. The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint. go.json sensing involved in spindle assembly checkpoint|spindle assembly checkpoint sensor mechanism|spindle assembly checkpoint sensor process True http://purl.obolibrary.org/obo/GO_0072484 GO:0072483 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072483 GO:0072482 biolink:BiologicalProcess response to mitotic cell cycle spindle orientation checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling. go.json mitotic cell cycle spindle orientation checkpoint effector process|response to signal involved in mitotic cell cycle spindle orientation checkpoint http://purl.obolibrary.org/obo/GO_0072482 GO:0072481 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic spindle orientation checkpoint OBSOLETE. The series of events in which information about whether the spindle is correctly oriented is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle orientation checkpoint. go.json detection of stimulus involved in mitotic cell cycle spindle orientation checkpoint|mitotic cell cycle spindle orientation checkpoint sensor mechanism|mitotic cell cycle spindle orientation checkpoint sensor process|sensing involved in mitotic cell cycle spindle orientation checkpoint True http://purl.obolibrary.org/obo/GO_0072481 GO:0106400 biolink:BiologicalProcess double-strand break repair via transcription-associated homologous recombination A mechanism of homologous recombination and DNA repair in which transcript RNA is used as a template for DSB repair. go.json http://purl.obolibrary.org/obo/GO_0106400 GO:0072480 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072480 GO:0106405 biolink:MolecularActivity isoprenoid diphosphate phosphatase activity Catalysis of the dephosphorylation of isoprenoid diphosphates. go.json http://purl.obolibrary.org/obo/GO_0106405 GO:0106402 biolink:BiologicalProcess Lewis x epitope biosynthetic process The chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide. go.json sLeX biosynthetic process|sialyl-Lewis X biosynthetic process http://purl.obolibrary.org/obo/GO_0106402 GO:0106409 biolink:MolecularActivity cyclic-di-AMP phosphodiesterase activity Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+. EC:3.1.4.59|MetaCyc:RXN-19814|RHEA:54420 go.json http://purl.obolibrary.org/obo/GO_0106409 GO:0106408 biolink:MolecularActivity diadenylate cyclase activity Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate. EC:2.7.7.85|MetaCyc:RXN-14338|RHEA:35655 go.json cyclic-di-AMP synthase http://purl.obolibrary.org/obo/GO_0106408 GO:0106407 biolink:MolecularActivity Glc2Man9GlcNAc2 oligosaccharide glucosidase activity Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose. go.json Glucosidase II http://purl.obolibrary.org/obo/GO_0106407 GO:0072489 biolink:BiologicalProcess methylammonium transmembrane transport The process in which methylammonium is transported across a membrane. go.json methylammonium membrane transport http://purl.obolibrary.org/obo/GO_0072489 GO:0072488 biolink:BiologicalProcess ammonium transmembrane transport The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. go.json ammonia transport|ammonium membrane transport|ammonium transport http://purl.obolibrary.org/obo/GO_0072488 GO:0072487 biolink:CellularComponent MSL complex A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3. go.json http://purl.obolibrary.org/obo/GO_0072487 GO:0072486 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072486 GO:0106411 biolink:MolecularActivity XMP 5'-nucleosidase activity Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine. EC:3.1.3.5|MetaCyc:XMPXAN-RXN|RHEA:28530 go.json http://purl.obolibrary.org/obo/GO_0106411 GO:0106410 biolink:BiologicalProcess box C/D RNA 5'-end processing Any process involved in forming the mature 5' end of a box C/D RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0106410 GO:0106415 biolink:MolecularActivity muramoyltetrapeptide carboxypeptidase activity GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. EC:3.4.17.13|RHEA:48688 go.json http://purl.obolibrary.org/obo/GO_0106415 GO:0106414 biolink:MolecularActivity mRNA dihydrouridine synthase activity Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+. go.json RHEA:69851|RHEA:69855 http://purl.obolibrary.org/obo/GO_0106414 GO:0106413 biolink:MolecularActivity RNA dihydrouridine synthase activity Catalysis of the reaction: RNA-uracil + NAD(P)+ = RNA-dihydrouridine + NAD(P)H + H+. go.json RHEA:54452|RHEA:69843 http://purl.obolibrary.org/obo/GO_0106413 GO:0106419 biolink:MolecularActivity NAD-dependent protein lipoamidase activity Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:63640 go.json http://purl.obolibrary.org/obo/GO_0106419 GO:0106418 biolink:MolecularActivity UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate. EC:6.3.2.45|RHEA:29563 go.json murein peptide ligase http://purl.obolibrary.org/obo/GO_0106418 GO:0106417 biolink:MolecularActivity dopaminechrome tautomerase activity Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole. RHEA:70199 go.json http://purl.obolibrary.org/obo/GO_0106417 GO:0106423 biolink:MolecularActivity tubulin-tyrosine carboxypeptidase Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine. EC:3.4.17.17|RHEA:57444 go.json tubulinyl-Tyr carboxypeptidase http://purl.obolibrary.org/obo/GO_0106423 GO:0106422 biolink:MolecularActivity carotenoid isomerooxygenase activity Catalysis of the reaction: Zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal. EC:1.13.11.65|RHEA:33931 go.json http://purl.obolibrary.org/obo/GO_0106422 GO:0106421 biolink:MolecularActivity L-glutamate:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out). go.json http://purl.obolibrary.org/obo/GO_0106421 GO:0106420 biolink:MolecularActivity NAD-dependent protein biotinidase activity Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:70479 go.json http://purl.obolibrary.org/obo/GO_0106420 GO:0106427 biolink:BiologicalProcess negative regulation of kainate selective glutamate receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0106427 GO:0106426 biolink:BiologicalProcess regulation of kainate selective glutamate receptor signaling pathway Any process that modulates the frequency, rate or extent of tge kainate selective glutamate receptor signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0106426 GO:0106425 biolink:MolecularActivity 3,4-dihydroxyphenylacetaldehyde synthase activity Catalysis of the reaction: L-dopa + O2 + H2O + H+ = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2. EC:4.1.1.107|RHEA:55524 go.json DHPAA synthase http://purl.obolibrary.org/obo/GO_0106425 GO:0106424 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106424 GO:0106429 biolink:MolecularActivity 11-cis-retinol dehydrogenase Catalysis of the reaction:11-cis-retinol-[retinal-binding-protein] + NAD+ = 11-cis-retinal-[retinol-binding-protein] + NADH. EC:1.1.1.315|RHEA:55668 go.json http://purl.obolibrary.org/obo/GO_0106429 GO:0106428 biolink:BiologicalProcess positive regulation of kainate selective glutamate receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0106428 GO:0047416 biolink:MolecularActivity arylalkyl acylamidase activity Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine. EC:3.5.1.76|MetaCyc:3.5.1.76-RXN|RHEA:10352 go.json N-acetylarylalkylamine amidohydrolase activity|aralkyl acylamidase activity http://purl.obolibrary.org/obo/GO_0047416 GO:0047415 biolink:MolecularActivity D-benzoylarginine-4-nitroanilide amidase activity Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H+. EC:3.5.1.72|KEGG_REACTION:R04113|MetaCyc:3.5.1.72-RXN|RHEA:14421 go.json D-BAPA-ase activity|N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity|benzoyl-D-arginine arylamidase activity http://purl.obolibrary.org/obo/GO_0047415 GO:0047414 biolink:MolecularActivity 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4. EC:3.5.1.66|KEGG_REACTION:R04397|MetaCyc:3.5.1.66-RXN|RHEA:17677|Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating,_decarboxylating) go.json 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)|alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity|compound B hydrolase activity http://purl.obolibrary.org/obo/GO_0047414 GO:0047413 biolink:MolecularActivity N(alpha)-benzyloxycarbonylleucine hydrolase activity Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H2O + H+ = L-leucine + benzyl alcohol + CO2. EC:3.5.1.64|KEGG_REACTION:R02552|MetaCyc:3.5.1.64-RXN|RHEA:18901 go.json alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity|benzyloxycarbonylleucine hydrolase activity|nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV|nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity|nalpha-benzyloxycarbonylleucine hydrolase activity http://purl.obolibrary.org/obo/GO_0047413 GO:0047412 biolink:MolecularActivity N-(long-chain-acyl)ethanolamine deacylase activity Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid. EC:3.5.1.60|MetaCyc:3.5.1.60-RXN|RHEA:17505 go.json N-(long-chain-acyl)ethanolamine amidohydrolase activity|N-acylethanolamine amidohydrolase activity|acylethanolamine amidase activity http://purl.obolibrary.org/obo/GO_0047412 GO:0047411 biolink:MolecularActivity 2-(acetamidomethylene)succinate hydrolase activity Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate. EC:3.5.1.29|MetaCyc:3.5.1.29-RXN|RHEA:10432 go.json 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)|alpha-(N-acetylaminomethylene)succinic acid hydrolase activity http://purl.obolibrary.org/obo/GO_0047411 GO:0047410 biolink:MolecularActivity N-formylmethionylaminoacyl-tRNA deformylase activity Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate. MetaCyc:3.5.1.27-RXN go.json N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047410 GO:0047419 biolink:MolecularActivity N-acetylgalactosamine-6-phosphate deacetylase activity Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate. EC:3.5.1.25|MetaCyc:3.5.1.80-RXN|RHEA:18149 go.json http://purl.obolibrary.org/obo/GO_0047419 GO:0047418 biolink:MolecularActivity phthalyl amidase activity Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine. EC:3.5.1.79|MetaCyc:3.5.1.79-RXN|RHEA:18297 go.json o-phthalyl amidase activity|phthalyl-amide amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047418 GO:0047417 biolink:MolecularActivity N-carbamoyl-D-amino acid hydrolase activity Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid. EC:3.5.1.77|MetaCyc:3.5.1.77-RXN|RHEA:11000 go.json N-carbamoyl-D-amino acid amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047417 GO:0047427 biolink:MolecularActivity cyanoalanine nitrilase activity Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4. EC:3.5.5.4|KEGG_REACTION:R00486|MetaCyc:3.5.5.4-RXN|RHEA:11188 go.json 3-cyano-L-alanine aminohydrolase activity|beta-cyanoalanine nitrilase activity http://purl.obolibrary.org/obo/GO_0047427 GO:0047426 biolink:MolecularActivity ricinine nitrilase activity Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone. EC:3.5.5.2|MetaCyc:3.5.5.2-RXN|RHEA:22704 go.json ricinine aminohydrolase activity http://purl.obolibrary.org/obo/GO_0047426 GO:0047425 biolink:MolecularActivity 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H2O + H+ = 2,5-dioxopentanoate + NH4. EC:3.5.4.22|KEGG_REACTION:R02280|MetaCyc:3.5.4.22-RXN|RHEA:10560 go.json 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)|HPC deaminase activity http://purl.obolibrary.org/obo/GO_0047425 GO:0047424 biolink:MolecularActivity methylenediurea deaminase activity Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea. EC:3.5.3.21|MetaCyc:3.5.3.21-RXN|RHEA:15929 go.json methylenediurea aminohydrolase activity|methylenediurease activity http://purl.obolibrary.org/obo/GO_0047424 GO:0047423 biolink:MolecularActivity N-methylhydantoinase (ATP-hydrolyzing) activity Catalysis of the reaction: N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + 3 H+ + phosphate. EC:3.5.2.14|KEGG_REACTION:R03187|MetaCyc:3.5.2.14-RXN|RHEA:11720|Wikipedia:N-methylhydantoinase_(ATP-hydrolysing) go.json N-methylhydantoin amidohydrolase activity|N-methylhydantoin hydrolase activity|N-methylhydantoinase (ATP-hydrolysing)|N-methylhydantoinase activity|N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)|methylhydantoin amidase activity http://purl.obolibrary.org/obo/GO_0047423 GO:0047422 biolink:MolecularActivity N-acyl-D-aspartate deacylase activity Catalysis of the reaction: N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate. EC:3.5.1.83|KEGG_REACTION:R02182|MetaCyc:3.5.1.83-RXN|RHEA:18285 go.json N-acyl-D-aspartate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047422 GO:0047421 biolink:MolecularActivity N-acyl-D-glutamate deacylase activity Catalysis of the reaction: N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate. EC:3.5.1.82|KEGG_REACTION:R01581|MetaCyc:3.5.1.82-RXN|RHEA:12833 go.json N-acyl-D-glutamate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047421 GO:0047420 biolink:MolecularActivity N-acyl-D-amino-acid deacylase activity Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid. EC:3.5.1.81|MetaCyc:3.5.1.81-RXN|RHEA:18309 go.json D-aminoacylase activity|N-acyl-D-amino acid amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047420 GO:0047429 biolink:MolecularActivity nucleoside triphosphate diphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. EC:3.6.1.9|MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN|Reactome:R-HSA-9755030 go.json nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphate diphosphohydrolase activity|nucleoside-triphosphate pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0047429 GO:0047428 biolink:MolecularActivity arylacetonitrilase activity Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3. EC:3.5.5.5|MetaCyc:3.5.5.5-RXN|RHEA:20657 go.json arylacetonitrile aminohydrolase activity http://purl.obolibrary.org/obo/GO_0047428 GO:0047430 biolink:MolecularActivity oligosaccharide-diphosphodolichol diphosphatase activity Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate. EC:3.6.1.44|MetaCyc:3.6.1.44-RXN|RHEA:15205 go.json oligosaccharide-diphosphodolichol phosphodolichohydrolase activity|oligosaccharide-diphosphodolichol pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0047430 GO:0047438 biolink:MolecularActivity 2-dehydro-3-deoxy-L-pentonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate. EC:4.1.2.18|MetaCyc:4.1.2.18-RXN|RHEA:18545 go.json 2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)|2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity|2-keto-3-deoxy-D-xylonate aldolase activity|2-keto-3-deoxy-L-arabonate aldolase activity|2-keto-3-deoxy-L-pentonate aldolase activity|3-deoxy-D-pentulosonic acid aldolase http://purl.obolibrary.org/obo/GO_0047438 GO:0047437 biolink:MolecularActivity 4-oxalocrotonate decarboxylase activity Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. EC:4.1.1.77|MetaCyc:4.1.1.77-RXN|RHEA:24260|UM-BBD_reactionID:r1435 go.json 4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)|4-oxalocrotonate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047437 GO:0047436 biolink:MolecularActivity arylmalonate decarboxylase activity Catalysis of the reaction: 2-aryl-2-methylmalonate + H+ = 2-arylpropionate + CO2. EC:4.1.1.76|KEGG_REACTION:R05173|MetaCyc:4.1.1.76-RXN|RHEA:20513 go.json 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)|2-aryl-2-methylmalonate carboxy-lyase activity|AMDASE|AMDase activity http://purl.obolibrary.org/obo/GO_0047436 GO:0047435 biolink:MolecularActivity 5-guanidino-2-oxopentanoate decarboxylase activity Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2. EC:4.1.1.75|KEGG_REACTION:R03178|MetaCyc:4.1.1.75-RXN|RHEA:11340 go.json 2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)|2-oxo-5-guanidinopentanoate carboxy-lyase activity|2-oxo-5-guanidinopentanoate decarboxylase activity|2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity|alpha-ketoarginine decarboxylase activity http://purl.obolibrary.org/obo/GO_0047435 GO:0047434 biolink:MolecularActivity indolepyruvate decarboxylase activity Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde. EC:4.1.1.74|MetaCyc:4.1.1.74-RXN|RHEA:18017 go.json 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]|3-(indol-3-yl)pyruvate carboxy-lyase activity|indol-3-yl-pyruvate carboxy-lyase activity|indole-3-pyruvate decarboxylase activity http://purl.obolibrary.org/obo/GO_0047434 GO:0047433 biolink:MolecularActivity branched-chain-2-oxoacid decarboxylase activity Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H+ = 2-methylbutanal + CO2. EC:4.1.1.72|KEGG_REACTION:R03894|MetaCyc:4.1.1.72-RXN|RHEA:21108 go.json (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)|(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity|BCKA|branched-chain alpha-keto acid decarboxylase activity|branched-chain keto acid decarboxylase activity|branched-chain oxo acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0047433 GO:0047432 biolink:MolecularActivity 2,2-dialkylglycine decarboxylase (pyruvate) activity Catalysis of the reaction: 2,2-dialkylglycine + H+ + pyruvate = L-alanine + CO2 + dialkyl ketone. EC:4.1.1.64|KEGG_REACTION:R03854|MetaCyc:4.1.1.64-RXN|RHEA:16073 go.json 2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity|2,2-dialkylglycine carboxy-lyase (amino-transferring)|2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)|L-alanine-alpha-ketobutyrate aminotransferase activity|alpha-dialkyl amino acid transaminase activity|dialkyl amino acid (pyruvate) decarboxylase activity|dialkylamino-acid decarboxylase (pyruvate) http://purl.obolibrary.org/obo/GO_0047432 GO:0047431 biolink:MolecularActivity 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H+ = 5-hydroxy-6-methylpyridine-3-carboxylate + CO2. EC:4.1.1.51|KEGG_REACTION:R03461|MetaCyc:4.1.1.51-RXN|RHEA:13669 go.json 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)|3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047431 GO:0047439 biolink:MolecularActivity 3-deoxy-D-manno-octulosonate aldolase activity Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate. EC:4.1.2.23|KEGG_REACTION:R01576|MetaCyc:4.1.2.23-RXN|RHEA:23340 go.json 2-keto-3-deoxyoctonate aldolase activity|2-keto-3-deoxyoctonic aldolase activity|3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)|3-deoxy-D-manno-octulosonate D-arabinose-lyase activity|3-deoxy-D-manno-octulosonic aldolase activity|3-deoxyoctulosonic aldolase activity|KDOaldolase activity http://purl.obolibrary.org/obo/GO_0047439 OIO:hasOBOFormatVersion biolink:OntologyClass has_obo_format_version go.json http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion GO:0047441 biolink:MolecularActivity 5-dehydro-2-deoxyphosphogluconate aldolase activity Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate. EC:4.1.2.29|KEGG_REACTION:R05378|MetaCyc:4.1.2.29-RXN|RHEA:13177 go.json 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)|5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity|phospho-5-dehydro-2-deoxygluconate aldolase activity|phospho-5-keto-2-deoxygluconate aldolase activity http://purl.obolibrary.org/obo/GO_0047441 GO:0047440 biolink:MolecularActivity 2-dehydro-3-deoxy-D-pentonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate. EC:4.1.2.28|KEGG_REACTION:R01782|MetaCyc:4.1.2.28-RXN|RHEA:20609 go.json 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity|2-keto-3-deoxy-D-pentonate aldolase activity|3-deoxy-D-pentulosonic acid aldolase http://purl.obolibrary.org/obo/GO_0047440 GO:0047449 biolink:MolecularActivity 2-dehydro-3-deoxy-L-arabinonate dehydratase activity Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O. EC:4.2.1.43|KEGG_REACTION:R02278|MetaCyc:4.2.1.43-RXN|RHEA:17201 go.json 2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)|2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity|2-keto-3-deoxy-L-arabinonate dehydratase activity http://purl.obolibrary.org/obo/GO_0047449 GO:0047448 biolink:MolecularActivity 5-dehydro-4-deoxyglucarate dehydratase activity Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H+ = 2,5-dioxopentanoate + CO2 + H2O. EC:4.2.1.41|KEGG_REACTION:R02279|MetaCyc:4.2.1.41-RXN|RHEA:24608 go.json 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)|5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)|5-keto-4-deoxy-glucarate dehydratase activity|D-4-deoxy-5-ketoglucarate hydro-lyase activity|deoxyketoglucarate dehydratase activity http://purl.obolibrary.org/obo/GO_0047448 GO:0047447 biolink:MolecularActivity erythro-3-hydroxyaspartate ammonia-lyase activity Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid. EC:4.3.1.20|MetaCyc:4.3.1.20-RXN|RHEA:19757 go.json 3-hydroxyaspartate dehydratase activity|erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity|erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)|erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity|erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)|erythro-3-hydroxyaspartate dehydratase activity|erythro-beta-hydroxyaspartate dehydratase activity http://purl.obolibrary.org/obo/GO_0047447 GO:0047446 biolink:MolecularActivity (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone. EC:4.1.3.35|KEGG_REACTION:R02232|MetaCyc:4.1.3.35-RXN|RHEA:23868 go.json (1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)|(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity http://purl.obolibrary.org/obo/GO_0047446 GO:0047445 biolink:MolecularActivity 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H+ = 7-methyl-3-oxooct-6-enoyl-CoA + acetate. EC:4.1.3.26|KEGG_REACTION:R08090|MetaCyc:4.1.3.26-RXN|RHEA:23084|UM-BBD_reactionID:r1168 go.json 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)|3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity|3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity|3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity|beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity|hydroxyisohexenylglutaryl-CoA:acetatelyase activity http://purl.obolibrary.org/obo/GO_0047445 GO:0047444 biolink:MolecularActivity N-acylneuraminate-9-phosphate synthase activity Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate. EC:2.5.1.57|MetaCyc:RXN-9988|RHEA:13421|Reactome:R-HSA-4084976 go.json N-acetylneuraminate 9-phosphate lyase activity|N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity|N-acetylneuraminate 9-phosphate synthetase activity|N-acetylneuraminic acid phosphate synthase activity|N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity|phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity|sialic acid 9-phosphate synthetase activity http://purl.obolibrary.org/obo/GO_0047444 GO:0047443 biolink:MolecularActivity 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. EC:4.1.3.17|MetaCyc:4.1.3.17-RXN|RHEA:22748 go.json 4-hydroxy-4-methyl-2-ketoglutarate aldolase activity|4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)|4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity|gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity|pyruvate aldolase activity http://purl.obolibrary.org/obo/GO_0047443 GO:0047442 biolink:MolecularActivity 17-alpha-hydroxyprogesterone aldolase activity Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. EC:4.1.2.30|MetaCyc:4.1.2.30-RXN|RHEA:14753 go.json 17-alpha-hydroxyprogesterone acetaldehyde-lyase activity|17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)|17alpha-hydroxyprogesterone acetaldehyde-lyase activity|17alpha-hydroxyprogesterone aldolase activity|C-17/C-20 lyase activity http://purl.obolibrary.org/obo/GO_0047442 GO:0047452 biolink:MolecularActivity protoaphin-aglucone dehydratase (cyclizing) activity Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin. EC:4.2.1.73|KEGG_REACTION:R03742|MetaCyc:4.2.1.73-RXN|RHEA:23876 go.json protoaphin dehydratase (cyclizing)|protoaphin dehydratase activity|protoaphin-aglucone hydro-lyase (cyclizing)|protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming) http://purl.obolibrary.org/obo/GO_0047452 GO:0047451 biolink:MolecularActivity (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + (2E)-octenoyl-[acyl-carrier protein]. KEGG_REACTION:R04537|MetaCyc:4.2.1.59-RXN|RHEA:41844 go.json (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity|3-hydroxyoctanoyl-ACP dehydratase activity|3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity|3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity http://purl.obolibrary.org/obo/GO_0047451 GO:0047450 biolink:MolecularActivity (3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity Catalysis of the reaction: (3R)-hydroxybutanoyl-[acyl-carrier-protein] = (2E)-butenoyl-[acyl-carrier-protein] + H2O. KEGG_REACTION:R04428|MetaCyc:4.2.1.58-RXN|RHEA:41808 go.json (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity|3-hydroxybutyryl acyl carrier protein dehydratase activity|beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity|crotonoyl-ACP hydratase activity|crotonoyl-[acyl-carrier protein] hydratase activity|crotonoyl-[acyl-carrier-protein] hydratase activity|crotonoyl-acyl-carrier-protein hydratase activity|crotonyl acyl carrier protein hydratase activity http://purl.obolibrary.org/obo/GO_0047450 GO:0047459 biolink:MolecularActivity 3-aminobutyryl-CoA ammonia-lyase activity Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH4. EC:4.3.1.14|KEGG_REACTION:R03030|MetaCyc:4.3.1.14-RXN|RHEA:10056 go.json L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)|L-3-aminobutyryl-CoA ammonia-lyase activity|L-3-aminobutyryl-CoA deaminase activity http://purl.obolibrary.org/obo/GO_0047459 GO:0047458 biolink:MolecularActivity beta-pyrazolylalanine synthase activity Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H+. EC:2.5.1.51|KEGG_REACTION:R03134|MetaCyc:2.5.1.51-RXN|RHEA:13117 go.json 3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity|BPA-synthase activity|O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity|O3-acetyl-L-serine acetate-lyase (adding pyrazole)|O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity|beta-(1-pyrazolyl)alanine synthase activity|beta-pyrazolealanine synthase activity|beta-pyrazolylalanine synthase (acetylserine) activity|pyrazolealanine synthase activity|pyrazolylalaninase activity http://purl.obolibrary.org/obo/GO_0047458 GO:0047457 biolink:MolecularActivity exo-(1,4)-alpha-D-glucan lyase activity Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose. EC:4.2.2.13|MetaCyc:4.2.2.13-RXN go.json (1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)|alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity|alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity|alpha-1,4-glucan exo-lyase activity|alpha-1,4-glucan lyase activity|exo-(1->4)-alpha-D-glucan lyase activity|exo-alpha-1,4-glucan lyase activity http://purl.obolibrary.org/obo/GO_0047457 GO:0047456 biolink:MolecularActivity 2-methylisocitrate dehydratase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O. EC:4.2.1.99|KEGG_REACTION:R04425|MetaCyc:4.2.1.99-RXN|RHEA:17941 go.json (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]|(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047456 GO:0047455 biolink:MolecularActivity 16-alpha-hydroxyprogesterone dehydratase activity Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. EC:4.2.1.98|MetaCyc:4.2.1.98-RXN|RHEA:12584 go.json 16-alpha-dehydroxylase activity|16-alpha-hydroxyprogesterone dehydroxylase activity|16-dehydroprogesterone hydratase activity|16alpha-dehydroxylase activity|16alpha-hydroxyprogesterone dehydratase activity|16alpha-hydroxyprogesterone dehydroxylase activity|16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)|16alpha-hydroxyprogesterone hydro-lyase activity|hydroxyprogesterone dehydroxylase activity http://purl.obolibrary.org/obo/GO_0047455 GO:0047454 biolink:MolecularActivity phaseollidin hydratase activity Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin. EC:4.2.1.97|KEGG_REACTION:R04728|MetaCyc:4.2.1.97-RXN|RHEA:19769 go.json phaseollidin-hydrate hydro-lyase (phaseollidin-forming)|phaseollidin-hydrate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047454 GO:0047453 biolink:MolecularActivity ATP-dependent NAD(P)H-hydrate dehydratase activity Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H+ + NADH + phosphate. EC:4.2.1.93|KEGG_REACTION:R00129|MetaCyc:4.2.1.93-RXN|RHEA:19017|Reactome:R-HSA-6806967 go.json (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)|(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)|ATP-dependent H(4)NAD(P)OH dehydratase activity|ATP-dependent H4NAD(P)OH dehydratase activity|reduced nicotinamide adenine dinucleotide hydrate dehydratase activity http://purl.obolibrary.org/obo/GO_0047453 GO:0072419 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072419 GO:0072418 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072418 GO:0072417 biolink:BiologicalProcess response to spindle checkpoint signaling A process that occurs in response to signals generated as a result of spindle checkpoint signaling. go.json response to signal involved in spindle checkpoint|spindle checkpoint effector process http://purl.obolibrary.org/obo/GO_0072417 GO:0072416 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072416 GO:0072415 biolink:BiologicalProcess obsolete detection of stimulus involved in spindle checkpoint OBSOLETE. The series of events in which information about the assembly, orientation or integrity of the spindle is received and converted into a molecular signal, contributing to a spindle checkpoint. go.json sensing involved in spindle checkpoint|spindle checkpoint sensor mechanism|spindle checkpoint sensor process True http://purl.obolibrary.org/obo/GO_0072415 GO:0072414 biolink:BiologicalProcess response to mitotic cell cycle checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling. go.json mitotic G2/M transition checkpoint effector process|mitotic cell cycle G1/S checkpoint effector process|mitotic cell cycle checkpoint effector process|response to mitotic G2/M transition checkpoint signal|response to mitotic cell cycle G1/S checkpoint signaling|response to signal involved in mitotic G2/M transition checkpoint|response to signal involved in mitotic cell cycle G1/S checkpoint|response to signal involved in mitotic cell cycle checkpoint http://purl.obolibrary.org/obo/GO_0072414 GO:0072413 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072413 GO:0072412 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic cell cycle checkpoint OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint. go.json detection of stimulus involved in mitotic cell cycle G1/S checkpoint|mitotic cell cycle G1/S checkpoint sensor mechanism|mitotic cell cycle G1/S checkpoint sensor process|mitotic cell cycle checkpoint sensor mechanism|mitotic cell cycle checkpoint sensor process|sensing involved in mitotic cell cycle G1/S checkpoint|sensing involved in mitotic cell cycle checkpoint True http://purl.obolibrary.org/obo/GO_0072412 GO:0072411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072411 GO:0072410 biolink:BiologicalProcess response to meiotic cell cycle checkpoint signaling A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint. go.json meiotic cell cycle checkpoint effector process|response to signal involved in meiotic cell cycle checkpoint http://purl.obolibrary.org/obo/GO_0072410 GO:0047463 biolink:MolecularActivity 2-aminohexano-6-lactam racemase activity Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam. EC:5.1.1.15|KEGG_REACTION:R04736|MetaCyc:5.1.1.15-RXN|RHEA:14813 go.json 2-amino-hexano-6-lactam racemase activity|alpha-amino-epsilon-caprolactam racemase activity http://purl.obolibrary.org/obo/GO_0047463 GO:0047462 biolink:MolecularActivity phenylalanine racemase (ATP-hydrolyzing) activity Catalysis of the reaction: L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + 2 H+. EC:5.1.1.11|KEGG_REACTION:R00686|MetaCyc:5.1.1.11-RXN|RHEA:20201 go.json gramicidin S synthetase I|phenylalanine racemase (ATP-hydrolysing)|phenylalanine racemase (adenosine triphosphate-hydrolysing)|phenylalanine racemase activity http://purl.obolibrary.org/obo/GO_0047462 GO:0047461 biolink:MolecularActivity (+)-delta-cadinene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene. EC:4.2.3.13|MetaCyc:4.6.1.11-RXN|RHEA:19525 go.json 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)|D-cadinene synthase activity http://purl.obolibrary.org/obo/GO_0047461 GO:0047460 biolink:MolecularActivity L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + H+ + NH4. EC:4.5.1.4|KEGG_REACTION:R02605|MetaCyc:4.5.1.4-RXN|RHEA:11620 go.json L-2-amino-4-chloro-4-pentenoate dehalogenase activity|L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)|L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating) http://purl.obolibrary.org/obo/GO_0047460 GO:0047469 biolink:MolecularActivity 4-carboxymethyl-4-methylbutenolide mutase activity Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide. EC:5.4.99.14|KEGG_REACTION:R04510|MetaCyc:5.4.99.14-RXN|RHEA:19237 go.json 4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity|4-methyl-2-enelactone isomerase activity|4-methyl-2-enelactone methyl-isomerase activity|4-methyl-3-enelactone methyl isomerase activity|4-methylmuconolactone methylisomerase activity http://purl.obolibrary.org/obo/GO_0047469 GO:0047468 biolink:MolecularActivity phosphoglucomutase (glucose-cofactor) activity Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor. EC:5.4.2.5|MetaCyc:RXN-16999 go.json alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)|glucose-1-phosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047468 GO:0047467 biolink:MolecularActivity 4-hydroxyphenylacetaldehyde-oxime isomerase activity Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime. go.json http://purl.obolibrary.org/obo/GO_0047467 GO:0047466 biolink:MolecularActivity 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide. EC:5.2.1.10|KEGG_REACTION:R04576|MetaCyc:5.2.1.10-RXN|RHEA:10924|UM-BBD_reactionID:r0278 go.json 2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity|2-chlorocarboxymethylenebutenolide isomerase activity|chlorodienelactone isomerase activity http://purl.obolibrary.org/obo/GO_0047466 GO:0047465 biolink:MolecularActivity N-acylglucosamine-6-phosphate 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. EC:5.1.3.9|MetaCyc:5.1.3.9-RXN|RHEA:23932 go.json N-acetylglucosmamine 6-phosphate 2-epimerase activity|N-acetylmannosamine-6-phosphate 2-epimerase activity|N-acyl-D-glucosamine-6-phosphate 2-epimerase activity|acylglucosamine phosphate 2-epimerase activity|acylglucosamine-6-phosphate 2-epimerase activity|acylmannosamine phosphate 2-epimerase activity http://purl.obolibrary.org/obo/GO_0047465 GO:0047464 biolink:MolecularActivity heparosan-N-sulfate-glucuronate 5-epimerase activity Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. EC:5.1.3.17|MetaCyc:5.1.3.17-RXN|RHEA:20197|Reactome:R-HSA-2024100|Reactome:R-HSA-2076371 go.json C-5 uronosyl epimerase activity|D-glucuronyl C-5 epimerase activity|heparosan epimerase activity|heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity|heparosan-N-sulphate-glucuronate 5-epimerase activity|poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity|polyglucuronate epimerase activity http://purl.obolibrary.org/obo/GO_0047464 GO:0072409 biolink:BiologicalProcess obsolete detection of stimulus involved in meiotic cell cycle checkpoint OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a meiotic cell cycle checkpoint. go.json meiotic cell cycle checkpoint sensor mechanism|meiotic cell cycle checkpoint sensor process|sensing involved in meiotic cell cycle checkpoint True http://purl.obolibrary.org/obo/GO_0072409 GO:0072408 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072408 GO:0072407 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072407 GO:0072406 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072406 GO:0072405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072405 GO:0072404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072404 GO:0072403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072403 GO:0072402 biolink:BiologicalProcess response to DNA integrity checkpoint signaling A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling. go.json DNA integrity checkpoint effector process|response to signal involved in DNA integrity checkpoint http://purl.obolibrary.org/obo/GO_0072402 GO:0072401 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072401 GO:0072400 biolink:BiologicalProcess obsolete detection of stimulus involved in mitotic DNA integrity checkpoint OBSOLETE. The series of events in which information about DNA integrity is received and converted into a molecular signal, contributing to a mitotic DNA integrity checkpoint. go.json DNA integrity checkpoint sensor mechanism|DNA integrity checkpoint sensor process|detection of stimulus involved in mitotic G2/M transition decatenation checkpoint|mitotic G2/M transition decatenation checkpoint sensor mechanism|mitotic G2/M transition decatenation checkpoint sensor process|sensing involved in DNA integrity checkpoint|sensing involved in mitotic G2/M transition decatenation checkpoint True http://purl.obolibrary.org/obo/GO_0072400 GO:0072430 biolink:BiologicalProcess obsolete detection of DNA damage stimulus involved in mitotic G1 DNA damage checkpoint OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition DNA damage checkpoint. go.json detection of DNA damage stimulus involved in mitotic cell cycle G1/S transition DNA damage checkpoint|mitotic cell cycle G1/S transition DNA damage checkpoint sensor mechanism|mitotic cell cycle G1/S transition DNA damage checkpoint sensor process|sensing involved in mitotic cell cycle G1/S transition DNA damage checkpoint True http://purl.obolibrary.org/obo/GO_0072430 GO:0047474 biolink:MolecularActivity long-chain fatty acid luciferin component ligase activity Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. EC:6.2.1.19|MetaCyc:6.2.1.19-RXN|RHEA:20101 go.json acyl-protein synthetase activity|long-chain-fatty-acid luciferin component ligase activity|long-chain-fatty-acid-luciferin-component ligase activity|long-chain-fatty-acid:protein ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0047474 GO:0047473 biolink:MolecularActivity D-alanine [D-alanyl carrier protein] ligase activity Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate. go.json D-alanine-D-alanyl carrier protein ligase activity|D-alanine-activating enzyme activity|D-alanine-poly(phosphoribitol) ligase activity|D-alanine:poly(phosphoribitol) ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0047473 GO:0047472 biolink:MolecularActivity 3-carboxy-cis,cis-muconate cycloisomerase activity Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. EC:5.5.1.2|KEGG_REACTION:R03307|MetaCyc:5.5.1.2-RXN|RHEA:23656|UM-BBD_reactionID:r0582 go.json 3-carboxymuconate cycloisomerase type II activity|3-carboxymuconate lactonizing enzyme activity|3-carboxymuconolactone hydrolase activity|CMLE activity|beta-carboxymuconate lactonizing enzyme activity http://purl.obolibrary.org/obo/GO_0047472 GO:0047471 biolink:MolecularActivity maltose alpha-D-glucosyltransferase activity Catalysis of the reaction: maltose = trehalose. EC:5.4.99.16|MetaCyc:5.4.99.16-RXN|RHEA:15145 go.json maltose alpha-D-glucosylmutase activity|maltose glucosylmutase activity|trehalose synthase activity http://purl.obolibrary.org/obo/GO_0047471 GO:0047470 biolink:MolecularActivity (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside. EC:5.4.99.15|MetaCyc:5.4.99.15-RXN|RHEA:13621 go.json (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase|malto-oligosyltrehalose synthase activity|maltodextrin alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047470 GO:0047479 biolink:MolecularActivity trypanothione synthase activity Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate. EC:6.3.1.9|MetaCyc:6.3.1.9-RXN|RHEA:21532 go.json TSR synthetase activity|glutathionylspermidine:glutathione ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0047479 GO:0047478 biolink:MolecularActivity aspartate-ammonia ligase (ADP-forming) activity Catalysis of the reaction: L-aspartate + ATP + NH4 = L-asparagine + ADP + 2 H+ + phosphate. EC:6.3.1.4|KEGG_REACTION:R00482|MetaCyc:6.3.1.4-RXN|RHEA:14197 go.json L-aspartate:ammonia ligase (ADP-forming)|asparagine synthetase (ADP-forming) activity|asparagine synthetase (adenosine diphosphate-forming) http://purl.obolibrary.org/obo/GO_0047478 GO:0047477 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047477 GO:0047476 biolink:MolecularActivity 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP. EC:6.2.1.28|MetaCyc:6.2.1.28-RXN|RHEA:21776 go.json 3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity|3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)|3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity|DHCA-CoA ligase activity http://purl.obolibrary.org/obo/GO_0047476 GO:0047475 biolink:MolecularActivity phenylacetate-CoA ligase activity Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA. EC:6.2.1.30|KEGG_REACTION:R02539|MetaCyc:RXN-10819|RHEA:20956 go.json PA-CoA ligase activity|phenacyl coenzyme A synthetase activity|phenylacetate:CoA ligase (AMP-forming)|phenylacetyl-CoA ligase (AMP-forming)|phenylacetyl-CoA ligase activity http://purl.obolibrary.org/obo/GO_0047475 GO:0072439 biolink:BiologicalProcess obsolete detection of stimulus involved in meiotic DNA replication checkpoint OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a meiotic DNA replication checkpoint. go.json meiotic DNA replication checkpoint sensor mechanism|meiotic DNA replication checkpoint sensor process|sensing involved in meiotic DNA replication checkpoint True http://purl.obolibrary.org/obo/GO_0072439 GO:0072438 biolink:BiologicalProcess response to DNA replication checkpoint signaling A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling. go.json DNA replication checkpoint effector process|response to signal involved in DNA replication checkpoint http://purl.obolibrary.org/obo/GO_0072438 GO:0072437 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072437 GO:0072436 biolink:BiologicalProcess obsolete detection of stimulus involved in DNA replication checkpoint OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a DNA replication checkpoint. go.json DNA replication checkpoint sensor mechanism|DNA replication checkpoint sensor process|sensing involved in DNA replication checkpoint True http://purl.obolibrary.org/obo/GO_0072436 GO:0072435 biolink:BiologicalProcess response to mitotic G2 DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling. go.json mitotic G2/M transition DNA damage checkpoint effector process|mitotic G2/M transition decatenation checkpoint effector process|response to mitotic G2/M transition DNA damage checkpoint signaling|response to mitotic G2/M transition decatenation checkpoint signaling|response to signal involved in mitotic G2/M transition DNA damage checkpoint|response to signal involved in mitotic G2/M transition decatenation checkpoint http://purl.obolibrary.org/obo/GO_0072435 GO:0072434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072434 GO:0072433 biolink:BiologicalProcess obsolete detection of DNA damage stimulus involved in mitotic G2 DNA damage checkpoint OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic G2/M transition DNA damage checkpoint. go.json G2/M transition DNA damage checkpoint sensor mechanism|detection of DNA damage stimulus involved in G2 DNA damage checkpoint|detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint|detection of DNA damage stimulus involved in mitotic G2/M transition DNA damage checkpoint|mitotic G2/M transition DNA damage checkpoint sensor mechanism|mitotic G2/M transition DNA damage checkpoint sensor process|sensing involved in G2/M transition DNA damage checkpoint|sensing involved in mitotic G2/M transition DNA damage checkpoint True http://purl.obolibrary.org/obo/GO_0072433 GO:0072432 biolink:BiologicalProcess response to G1 DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling. go.json mitotic cell cycle G1/S transition DNA damage checkpoint effector process|response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0072432 GO:0072431 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072431 GO:0047485 biolink:MolecularActivity obsolete protein N-terminus binding OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. go.json N-terminal binding|N-terminal end binding|NH2-terminal binding|NH2-terminus binding|amino-terminal binding|amino-terminus binding True http://purl.obolibrary.org/obo/GO_0047485 GO:0047484 biolink:BiologicalProcess regulation of response to osmotic stress Any process that modulates the rate or extent of the response to osmotic stress. go.json http://purl.obolibrary.org/obo/GO_0047484 GO:0047483 biolink:MolecularActivity imidazoleacetate-phosphoribosyldiphosphate ligase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H+ + phosphate. EC:6.3.4.8|KEGG_REACTION:R04068|MetaCyc:6.3.4.8-RXN|RHEA:16485 go.json 5-phosphoribosylimidazoleacetate synthetase activity|imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming) http://purl.obolibrary.org/obo/GO_0047483 GO:0047482 biolink:MolecularActivity UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine. EC:6.3.2.7|KEGG_REACTION:R02786|MetaCyc:6.3.2.7-RXN|RHEA:17969 go.json L-lysine-adding enzyme activity|MurE synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity|UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity|uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity http://purl.obolibrary.org/obo/GO_0047482 GO:0047481 biolink:MolecularActivity D-alanine-alanyl-poly(glycerolphosphate) ligase activity Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP. EC:6.3.2.16|MetaCyc:6.3.2.16-RXN go.json D-alanine-membrane acceptor-ligase activity|D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)|D-alanine:membrane-acceptor ligase activity|D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity|D-alanyl-poly(phosphoglycerol) synthetase activity|D-alanylalanylpoly(phosphoglycerol) synthetase activity http://purl.obolibrary.org/obo/GO_0047481 GO:0047480 biolink:MolecularActivity UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. EC:6.3.2.10|MetaCyc:6.3.2.10-RXN|RHEA:16085 go.json MurF synthetase activity|UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity|UDP-MurNAc-pentapeptide synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity|UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity|UDPacetylmuramoylpentapeptide synthetase activity|uridine diphosphoacetylmuramoylpentapeptide synthetase activity http://purl.obolibrary.org/obo/GO_0047480 GO:0047489 biolink:MolecularActivity pectate disaccharide-lyase activity Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin. EC:4.2.2.9|MetaCyc:4.2.2.9-RXN|RHEA:57104 go.json (1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity|Exo-PATE activity|Exo-PGL activity|PATE activity|exo-PATE|exo-PGL|exopectate lyase activity|exopectic acid transeliminase activity|exopolygalacturonate lyase activity|exopolygalacturonic acid-trans-eliminase activity|pectate exo-lyase activity http://purl.obolibrary.org/obo/GO_0047489 GO:0047488 biolink:MolecularActivity heparin lyase activity Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends. EC:4.2.2.7|MetaCyc:4.2.2.7-RXN go.json heparan sulfate lyase activity|heparin eliminase activity|heparinase activity http://purl.obolibrary.org/obo/GO_0047488 GO:0047487 biolink:MolecularActivity oligogalacturonide lyase activity Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate. EC:4.2.2.6|MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN|RHEA:20269 go.json OGTE|oligogalacturonate lyase activity|unsaturated oligogalacturonate transeliminase activity http://purl.obolibrary.org/obo/GO_0047487 GO:0047486 biolink:MolecularActivity obsolete chondroitin ABC lyase activity OBSOLETE. Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. go.json True http://purl.obolibrary.org/obo/GO_0047486 GO:0072429 biolink:BiologicalProcess response to intra-S DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling. go.json intra-S DNA damage checkpoint effector process|response to signal involved in intra-S DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0072429 GO:0072428 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072428 GO:0072427 biolink:BiologicalProcess obsolete detection of DNA damage stimulus involved in intra-S DNA damage checkpoint OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to an intra-S DNA damage checkpoint. go.json intra-S DNA damage checkpoint sensor mechanism|intra-S DNA damage checkpoint sensor process|sensing involved in intra-S DNA damage checkpoint True http://purl.obolibrary.org/obo/GO_0072427 GO:0072426 biolink:BiologicalProcess response to G2 DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling. go.json G2/M transition DNA damage checkpoint effector process|response to signal involved in G2/M transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0072426 GO:0072425 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072425 GO:0072424 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072424 GO:0072423 biolink:BiologicalProcess response to DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling. go.json DNA damage checkpoint effector process|response to signal involved in DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0072423 GO:0072422 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072422 GO:0072421 biolink:BiologicalProcess obsolete detection of DNA damage stimulus involved in DNA damage checkpoint OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a DNA damage checkpoint. go.json DNA damage checkpoint sensor mechanism|DNA damage checkpoint sensor process|sensing involved in DNA damage checkpoint True http://purl.obolibrary.org/obo/GO_0072421 GO:0072420 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072420 GO:0047603 biolink:MolecularActivity acetoacetyl-CoA hydrolase activity Catalysis of the reaction: acetoacetyl-CoA + H2O = acetoacetate + CoA + H+. EC:3.1.2.11|KEGG_REACTION:R01358|MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN|RHEA:15673 go.json acetoacetyl CoA deacylase activity|acetoacetyl coenzyme A deacylase activity|acetoacetyl coenzyme A hydrolase activity http://purl.obolibrary.org/obo/GO_0047603 GO:0047602 biolink:MolecularActivity acetoacetate decarboxylase activity Catalysis of the reaction: acetoacetate + H+ = acetone + CO2. EC:4.1.1.4|KEGG_REACTION:R01366|MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN|RHEA:19729 go.json acetoacetate carboxy-lyase (acetone-forming)|acetoacetate carboxy-lyase activity|acetoacetic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0047602 GO:0047601 biolink:MolecularActivity acetate kinase (diphosphate) activity Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate. EC:2.7.2.12|KEGG_REACTION:R00320|MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN|RHEA:24276 go.json acetate kinase (pyrophosphate) activity|diphosphate:acetate phosphotransferase activity|pyrophosphate-acetate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047601 GO:0047600 biolink:MolecularActivity abequosyltransferase activity Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid. EC:2.4.1.60|MetaCyc:ABEQUOSYLTRANSFERASE-RXN|RHEA:34183 go.json CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity|trihexose diphospholipid abequosyltransferase activity http://purl.obolibrary.org/obo/GO_0047600 GO:0047609 biolink:MolecularActivity acetylputrescine deacetylase activity Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine. EC:3.5.1.62|KEGG_REACTION:R01156|MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN|RHEA:23412 go.json N-acetylputrescine acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0047609 GO:0047608 biolink:MolecularActivity acetylindoxyl oxidase activity Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown. EC:1.7.3.2|MetaCyc:ACETYLINDOXYL-OXIDASE-RXN|RHEA:16941 go.json N-acetylindoxyl:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047608 GO:0047607 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047607 GO:0047606 biolink:MolecularActivity hydroxynitrilase activity Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone. EC:4.1.2.47|MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN|https://github.com/geneontology/go-ontology/issues/16166 go.json alpha-hydroxynitrile lyase activity|hydroxynitrile lyase activity|oxynitrilase activity http://purl.obolibrary.org/obo/GO_0047606 GO:0047605 biolink:MolecularActivity acetolactate decarboxylase activity Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. EC:4.1.1.5|MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN|RHEA:21580 go.json (S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]|(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity|alpha-acetolactate decarboxylase activity http://purl.obolibrary.org/obo/GO_0047605 GO:0047604 biolink:MolecularActivity acetoin racemase activity Catalysis of the reaction: (S)-acetoin = (R)-acetoin. EC:5.1.2.4|KEGG_REACTION:R02949|MetaCyc:ACETOIN-RACEMASE-RXN|RHEA:12092 go.json acetylmethylcarbinol racemase activity http://purl.obolibrary.org/obo/GO_0047604 GO:0047614 biolink:MolecularActivity aconitate delta-isomerase activity Catalysis of the reaction: trans-aconitate = cis-aconitate. EC:5.3.3.7|KEGG_REACTION:R02244|MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN|RHEA:17265 go.json aconitate D-isomerase activity|aconitate delta2-delta3-isomerase activity|aconitate isomerase activity http://purl.obolibrary.org/obo/GO_0047614 GO:0047613 biolink:MolecularActivity aconitate decarboxylase activity Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate. EC:4.1.1.6|KEGG_REACTION:R02243|MetaCyc:ACONITATE-DECARBOXYLASE-RXN|RHEA:15253 go.json CAD activity|cis-aconitate carboxy-lyase (itaconate-forming)|cis-aconitate carboxy-lyase activity|cis-aconitic decarboxylase activity http://purl.obolibrary.org/obo/GO_0047613 GO:0047612 biolink:MolecularActivity acid-CoA ligase (GDP-forming) activity Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H+ + phosphate. EC:6.2.1.10|KEGG_REACTION:R00394|MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN|RHEA:10968 go.json acid:CoA ligase (GDP-forming)|acyl coenzyme A synthetase (guanosine diphosphate forming)|acyl-CoA synthetase (GDP-forming) activity http://purl.obolibrary.org/obo/GO_0047612 GO:0047611 biolink:MolecularActivity acetylspermidine deacetylase activity Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine. EC:3.5.1.48|KEGG_REACTION:R07300|MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN|RHEA:23928 go.json 8-N-acetylspermidine amidohydrolase activity|N(1)-acetylspermidine amidohydrolase activity|N(8)-acetylspermidine amidohydrolase activity|N(8)-acetylspermidine deacetylase activity|N(8)-monoacetylspermidine deacetylase activity|N-acetylspermidine deacetylase activity|N1-acetylspermidine amidohydrolase activity|N8-acetylspermidine amidohydrolase activity|N8-acetylspermidine deacetylase activity|N8-monoacetylspermidine deacetylase activity http://purl.obolibrary.org/obo/GO_0047611 GO:0047610 biolink:MolecularActivity acetylsalicylate deacetylase activity Catalysis of the reaction: acetylsalicylate + H2O = acetate + H+ + salicylate. EC:3.1.1.55|KEGG_REACTION:R02942|MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN|RHEA:11752 go.json acetylsalicylate O-acetylhydrolase activity|acetylsalicylic acid esterase activity|aspirin esterase activity|aspirin hydrolase activity http://purl.obolibrary.org/obo/GO_0047610 GO:0047619 biolink:MolecularActivity acylcarnitine hydrolase activity Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine. EC:3.1.1.28|MetaCyc:ACYLCARNITINE-HYDROLASE-RXN|RHEA:17101 go.json HACH|O-acylcarnitine acylhydrolase activity|carnitine ester hydrolase activity|high activity acylcarnitine hydrolase activity|long-chain acyl-L-carnitine hydrolase activity|palmitoyl carnitine hydrolase activity|palmitoyl-L-carnitine hydrolase activity|palmitoylcarnitine hydrolase activity http://purl.obolibrary.org/obo/GO_0047619 GO:0047618 biolink:MolecularActivity acylagmatine amidase activity Catalysis of the reaction: N(4)-benzoylagmatine + H2O = agmatine + benzoate. EC:3.5.1.40|KEGG_REACTION:R01425|MetaCyc:ACYLAGMATINE-AMIDASE-RXN|RHEA:15065 go.json acylagmatine amidohydrolase activity|acylagmatine deacylase activity|benzoylagmatine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047618 GO:0047617 biolink:MolecularActivity acyl-CoA hydrolase activity Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. EC:3.1.2.20|MetaCyc:ACYL-COA-HYDROLASE-RXN|RHEA:16781|Reactome:R-HSA-5690042|Reactome:R-HSA-5690043|Reactome:R-HSA-5690066 go.json acyl coenzyme A hydrolase activity|acyl coenzyme A thioesterase activity|acyl-CoA thioesterase I activity|acyl-CoA thioesterase II activity|acyl-CoA thioesterase activity|acyl-CoA thiolesterase activity|thioesterase B|thioesterase II http://purl.obolibrary.org/obo/GO_0047617 GO:0047616 biolink:MolecularActivity acyl-CoA dehydrogenase (NADP+) activity Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+. EC:1.3.1.8|MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN|RHEA:22460 go.json 2-enoyl-CoA reductase activity|acyl-CoA:NADP+ 2-oxidoreductase activity|crotonyl coenzyme A reductase activity|dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)|enoyl coenzyme A reductase activity http://purl.obolibrary.org/obo/GO_0047616 GO:0047615 biolink:MolecularActivity actinomycin lactonase activity Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone. EC:3.1.1.39|MetaCyc:ACTINOMYCIN-LACTONASE-RXN go.json actinomycin lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0047615 GO:0047625 biolink:MolecularActivity adenosylmethionine cyclotransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone. EC:2.5.1.4|KEGG_REACTION:R00180|MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN|RHEA:21932 go.json S-adenosyl-L-methionine alkyltransferase (cyclizing)|adenosyl methionine cyclotransferase activity|adenosylmethioninase activity http://purl.obolibrary.org/obo/GO_0047625 GO:0047624 biolink:MolecularActivity adenosine-tetraphosphatase activity Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate. EC:3.6.1.14|MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN|RHEA:24500 go.json adenosine-tetraphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047624 GO:0047623 biolink:MolecularActivity adenosine-phosphate deaminase activity Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. EC:3.5.4.17 go.json adenine nucleotide deaminase activity|adenosine (phosphate) deaminase activity|adenosine-phosphate aminohydrolase activity http://purl.obolibrary.org/obo/GO_0047623 GO:0047622 biolink:MolecularActivity adenosine nucleosidase activity Catalysis of the reaction: adenosine + H2O = D-ribose + adenine. EC:3.2.2.7|MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN|RHEA:18669 go.json ANase activity|N-ribosyladenine ribohydrolase activity|adenosinase activity|adenosine hydrolase activity|adenosine ribohydrolase activity http://purl.obolibrary.org/obo/GO_0047622 GO:0047621 biolink:MolecularActivity acylpyruvate hydrolase activity Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate. EC:3.7.1.5|MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN|RHEA:19009|UM-BBD_reactionID:r1401 go.json 3-acylpyruvate acylhydrolase activity http://purl.obolibrary.org/obo/GO_0047621 GO:0047620 biolink:MolecularActivity acylglycerol kinase activity Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. EC:2.7.1.94|MetaCyc:ACYLGLYCEROL-KINASE-RXN|RHEA:19293|Reactome:R-HSA-5696074 go.json ATP:acylglycerol 3-phosphotransferase activity|MGK|monoacylglycerol kinase (phosphorylating)|monoacylglycerol kinase activity|monoglyceride kinase activity|monoglyceride phosphokinase activity|sn-2-monoacylglycerol kinase activity http://purl.obolibrary.org/obo/GO_0047620 GO:0047629 biolink:MolecularActivity ADP deaminase activity Catalysis of the reaction: ADP + H2O = IDP + NH3. EC:3.5.4.7|MetaCyc:ADP-DEAMINASE-RXN|RHEA:12741 go.json ADP aminohydrolase activity|adenosine diphosphate deaminase activity|adenosinepyrophosphate deaminase activity http://purl.obolibrary.org/obo/GO_0047629 GO:0047628 biolink:MolecularActivity ADP-thymidine kinase activity Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate. EC:2.7.1.118|MetaCyc:ADP--THYMIDINE-KINASE-RXN|RHEA:13413 go.json ADP:dThd phosphotransferase activity|ADP:thymidine 5'-phosphotransferase activity|adenosine diphosphate-thymidine phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047628 GO:0047627 biolink:MolecularActivity adenylylsulfatase activity Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate. EC:3.6.2.1|KEGG_REACTION:R00531|MetaCyc:ADENYLYLSULFATASE-RXN|RHEA:17041 go.json adenosine 5-phosphosulfate sulfohydrolase activity|adenylylsulfate sulfohydrolase activity|adenylylsulphatase activity http://purl.obolibrary.org/obo/GO_0047627 GO:0047626 biolink:MolecularActivity obsolete adenosylmethionine hydrolase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + H2O = S-methyl-5'-thioadenosine + L-homoserine + H+. go.json adenosyl methionine hydrolase activity True http://purl.obolibrary.org/obo/GO_0047626 GO:0047636 biolink:MolecularActivity alanopine dehydrogenase activity Catalysis of the reaction: 2,2'-iminodipropanoate + H2O + NAD+ = L-alanine + H+ + NADH + pyruvate. EC:1.5.1.17|KEGG_REACTION:R00398|MetaCyc:ALANOPINE-DEHYDROGENASE-RXN|RHEA:17589 go.json 2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)|ADH|ALPDH|alanopine: NAD oxidoreductase activity|alanopine:NAD oxidoreductase activity|alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity|meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047636 GO:0047635 biolink:MolecularActivity alanine-oxo-acid transaminase activity Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid. EC:2.6.1.12|MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN|RHEA:19953 go.json L-alanine-alpha-keto acid aminotransferase activity|L-alanine:2-oxo-acid aminotransferase activity|alanine--oxo-acid aminotransferase activity|alanine-keto acid aminotransferase activity|alanine-oxo acid aminotransferase activity|alanine-oxo-acid aminotransferase activity|leucine-alanine transaminase activity http://purl.obolibrary.org/obo/GO_0047635 GO:0047634 biolink:MolecularActivity agmatine N4-coumaroyltransferase activity Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+. EC:2.3.1.64|KEGG_REACTION:R01617|MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN|RHEA:13405 go.json 4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity|4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity|agmatine coumaroyltransferase activity|p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity http://purl.obolibrary.org/obo/GO_0047634 GO:0047633 biolink:MolecularActivity agmatine kinase activity Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H+. EC:2.7.3.10|KEGG_REACTION:R01417|MetaCyc:AGMATINE-KINASE-RXN|RHEA:15953 go.json ATP:agmatine 4-N-phosphotransferase activity|ATP:agmatine N4-phosphotransferase activity|phosphagen phosphokinase activity http://purl.obolibrary.org/obo/GO_0047633 GO:0047632 biolink:MolecularActivity agmatine deiminase activity Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3. EC:3.5.3.12|MetaCyc:AGMATINE-DEIMINASE-RXN|RHEA:18037 go.json agmatine amidinohydrolase|agmatine iminohydrolase activity http://purl.obolibrary.org/obo/GO_0047632 GO:0047631 biolink:MolecularActivity ADP-ribose diphosphatase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. EC:3.6.1.13|MetaCyc:RXN0-1441|RHEA:10412|Reactome:R-HSA-2393939|Reactome:R-HSA-2393954|Reactome:R-HSA-5696049 go.json ADP-ribose phosphohydrolase activity|ADP-ribose pyrophosphatase activity|ADP-ribose ribophosphohydrolase activity|ADPR-PPase activity|ADPribose diphosphatase activity|ADPribose pyrophosphatase activity|adenosine diphosphoribose pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0047631 GO:0047630 biolink:MolecularActivity ADP-phosphoglycerate phosphatase activity Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate. EC:3.1.3.28|KEGG_REACTION:R03969|MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN|RHEA:15861 go.json 3-(ADP)-2-phosphoglycerate phosphohydrolase activity|ADPphosphoglycerate phosphatase activity|adenosine diphosphate phosphoglycerate phosphatase activity http://purl.obolibrary.org/obo/GO_0047630 GO:0047639 biolink:MolecularActivity alcohol oxidase activity Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2. EC:1.1.3.13|MetaCyc:ALCOHOL-OXIDASE-RXN|RHEA:19829 go.json AOX activity|alcohol:oxygen oxidoreductase activity|ethanol oxidase activity http://purl.obolibrary.org/obo/GO_0047639 GO:0047638 biolink:MolecularActivity albendazole monooxygenase activity Catalysis of the reaction: albendazole + H+ + NADPH + O2 = albendazole S-oxide + H2O + NADP+. EC:1.14.13.32|KEGG_REACTION:R03712|MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN|RHEA:10796 go.json albendazole oxidase activity|albendazole sulfoxidase activity|albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming) http://purl.obolibrary.org/obo/GO_0047638 GO:0047637 biolink:MolecularActivity phosphatidylglycerol alanyltransferase activity Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala). EC:2.3.2.11|MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN|RHEA:20489 go.json alanyl phosphatidylglycerol synthetase activity http://purl.obolibrary.org/obo/GO_0047637 GO:0047647 biolink:MolecularActivity alkylacetylglycerophosphatase activity Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate. EC:3.1.3.59|KEGG_REACTION:R03454|MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN|RHEA:18221 go.json 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity|1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity|alkylacetylglycerophosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0047647 GO:0047646 biolink:MolecularActivity alkanal monooxygenase (FMN-linked) activity Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light. EC:1.14.14.3|MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN|RHEA:17181 go.json aldehyde monooxygenase activity|alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)|bacterial luciferase activity|vibrio fischeri luciferase activity http://purl.obolibrary.org/obo/GO_0047646 GO:0047645 biolink:MolecularActivity alkan-1-ol dehydrogenase (acceptor) activity Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor. EC:1.1.99.20|MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN|RHEA:14685 go.json alkan-1-ol:(acceptor) oxidoreductase activity|alkan-1-ol:acceptor oxidoreductase activity|polyethylene glycol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047645 GO:0047644 biolink:MolecularActivity alizarin 2-beta-glucosyltransferase activity Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H+ + UDP. EC:2.4.1.103|KEGG_REACTION:R03573|MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:20677 go.json UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity|UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity|alizarin 2-b-glucosyltransferase activity|uridine diphosphoglucose-alizarin glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047644 GO:0047643 biolink:MolecularActivity alginate synthase activity Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1). EC:2.4.1.33|MetaCyc:ALGINATE-SYNTHASE-RXN|RHEA:46876 go.json GDP-D-mannuronate:alginate D-mannuronyltransferase activity|mannuronosyl transferase activity http://purl.obolibrary.org/obo/GO_0047643 GO:0047642 biolink:MolecularActivity aldose beta-D-fructosyltransferase activity Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside. EC:2.4.1.162|MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN go.json aldose b-D-fructosyltransferase activity|alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity http://purl.obolibrary.org/obo/GO_0047642 GO:0047641 biolink:MolecularActivity aldose-6-phosphate reductase (NADPH) activity Catalysis of the reaction: D-glucitol 6-phosphate + NADP+ = D-glucose 6-phosphate + H+ + NADPH. EC:1.1.1.200|KEGG_REACTION:R00834|MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN|RHEA:20037 go.json A6PR|D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity|NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity|NADP-dependent aldose 6-phosphate reductase activity|alditol 6-phosphate:NADP 1-oxidoreductase activity|aldose 6-phosphate reductase activity|aldose-6-P reductase activity|aldose-6-phosphate reductase activity http://purl.obolibrary.org/obo/GO_0047641 GO:0047640 biolink:MolecularActivity aldose 1-dehydrogenase activity Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH. EC:1.1.1.121|MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN|RHEA:15917 go.json D-aldose:NAD+ 1-oxidoreductase activity|aldose dehydrogenase activity|dehydrogenase, D-aldohexose http://purl.obolibrary.org/obo/GO_0047640 GO:0047649 biolink:MolecularActivity alkylglycerol kinase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+. EC:2.7.1.93|KEGG_REACTION:R04126|MetaCyc:ALKYLGLYCEROL-KINASE-RXN|RHEA:16937 go.json 1-alkylglycerol kinase (phosphorylating)|ATP-alkylglycerol phosphotransferase activity|ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity|ATP:1-alkyl-sn-glycerol phosphotransferase activity|alkylglycerol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047649 GO:0047648 biolink:MolecularActivity alkylamidase activity Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylammonium. EC:3.5.1.39|KEGG_REACTION:R03620|MetaCyc:ALKYLAMIDASE-RXN|RHEA:20081 go.json N-methylhexanamide amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047648 GO:0033009 biolink:CellularComponent nucleomorph A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively. Wikipedia:Nucleomorph go.json http://purl.obolibrary.org/obo/GO_0033009 GO:0033008 biolink:BiologicalProcess positive regulation of mast cell activation involved in immune response Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. go.json positive regulation of mast cell activation during immune response http://purl.obolibrary.org/obo/GO_0033008 GO:0033007 biolink:BiologicalProcess negative regulation of mast cell activation involved in immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response. go.json negative regulation of mast cell activation during immune response http://purl.obolibrary.org/obo/GO_0033007 GO:0008049 biolink:BiologicalProcess male courtship behavior The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster. go.json male courtship behaviour http://purl.obolibrary.org/obo/GO_0008049 GO:0008048 biolink:MolecularActivity calcium sensitive guanylate cyclase activator activity Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. go.json http://purl.obolibrary.org/obo/GO_0008048 GO:0008047 biolink:MolecularActivity enzyme activator activity Binds to and increases the activity of an enzyme. go.json metalloenzyme activator activity http://purl.obolibrary.org/obo/GO_0008047 GO:0008046 biolink:MolecularActivity axon guidance receptor activity Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. go.json receptor activity involved in axon guidance http://purl.obolibrary.org/obo/GO_0008046 GO:0008045 biolink:BiologicalProcess motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. go.json motoneuron axon guidance|motor axon guidance|motor axon pathfinding http://purl.obolibrary.org/obo/GO_0008045 GO:0008044 biolink:BiologicalProcess obsolete adult behavior (sensu Insecta) OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects. go.json adult behavior (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0008044 GO:0008043 biolink:CellularComponent intracellular ferritin complex A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains. go.json http://purl.obolibrary.org/obo/GO_0008043 GO:0008053 biolink:BiologicalProcess mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment. go.json mitochondrial membrane fusion|mitochondrion fusion http://purl.obolibrary.org/obo/GO_0008053 GO:0008052 biolink:BiologicalProcess sensory organ boundary specification The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained. go.json sense organ boundary specification http://purl.obolibrary.org/obo/GO_0008052 GO:0008051 biolink:CellularComponent obsolete farnesyl-diphosphate farnesyl transferase complex OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity. go.json farnesyl-diphosphate farnesyl transferase complex True http://purl.obolibrary.org/obo/GO_0008051 GO:0008050 biolink:BiologicalProcess female courtship behavior The behavior of a female, for the purpose of attracting a sexual partner. go.json female courtship behaviour http://purl.obolibrary.org/obo/GO_0008050 GO:0033006 biolink:BiologicalProcess regulation of mast cell activation involved in immune response Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. go.json regulation of mast cell activation during immune response http://purl.obolibrary.org/obo/GO_0033006 GO:0033005 biolink:BiologicalProcess positive regulation of mast cell activation Any process that activates or increases the frequency, rate, or extent of mast cell activation. go.json http://purl.obolibrary.org/obo/GO_0033005 GO:0033004 biolink:BiologicalProcess negative regulation of mast cell activation Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. go.json http://purl.obolibrary.org/obo/GO_0033004 GO:0033003 biolink:BiologicalProcess regulation of mast cell activation Any process that modulates the frequency, rate, or extent of mast cell activation. go.json http://purl.obolibrary.org/obo/GO_0033003 GO:0033002 biolink:BiologicalProcess muscle cell proliferation The expansion of a muscle cell population by cell division. go.json myocyte proliferation http://purl.obolibrary.org/obo/GO_0033002 GO:0033001 biolink:CellularComponent Fc-gamma receptor III complex A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. go.json FcgRIII complex|IgG receptor complex|immunoglobulin G receptor complex http://purl.obolibrary.org/obo/GO_0033001 GO:0033000 biolink:CellularComponent Fc-gamma receptor I complex A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG. go.json FcgRI complex|IgG receptor complex|immunoglobulin G receptor complex http://purl.obolibrary.org/obo/GO_0033000 GO:0008059 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008059 GO:0008058 biolink:BiologicalProcess ocellus pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus. go.json ocellus pigment granule organisation|ocellus pigment granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0008058 GO:0008057 biolink:BiologicalProcess eye pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye. go.json eye pigment granule organisation|eye pigment granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0008057 GO:0008056 biolink:BiologicalProcess ocellus development The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects. go.json http://purl.obolibrary.org/obo/GO_0008056 GO:0008055 biolink:BiologicalProcess ocellus pigment biosynthetic process The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. go.json ocellus pigment anabolism|ocellus pigment biosynthesis|ocellus pigment formation|ocellus pigment synthesis http://purl.obolibrary.org/obo/GO_0008055 GO:0008054 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008054 GO:0008064 biolink:BiologicalProcess regulation of actin polymerization or depolymerization Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. go.json http://purl.obolibrary.org/obo/GO_0008064 GO:0008063 biolink:BiologicalProcess Toll signaling pathway The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json Tl signaling pathway|Tl signalling pathway|Toll signalling pathway http://purl.obolibrary.org/obo/GO_0008063 GO:0008062 biolink:BiologicalProcess eclosion rhythm The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn. go.json http://purl.obolibrary.org/obo/GO_0008062 GO:0008061 biolink:MolecularActivity chitin binding Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. go.json http://purl.obolibrary.org/obo/GO_0008061 goslim_drosophila GO:0008060 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008060 GO:0008029 biolink:MolecularActivity pentraxin receptor activity Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json pentaxin receptor http://purl.obolibrary.org/obo/GO_0008029 GO:0008028 biolink:MolecularActivity monocarboxylic acid transmembrane transporter activity Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. Reactome:R-HSA-429749|Reactome:R-HSA-433698|Reactome:R-HSA-5624211|Reactome:R-HSA-9645220 go.json monocarboxylate carrier|prostaglandin/thromboxane transporter activity http://purl.obolibrary.org/obo/GO_0008028 GO:0008027 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008027 GO:0008026 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008026 GO:0008025 biolink:MolecularActivity obsolete diazepam binding inhibitor activity OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters. go.json DBI|diazepam binding inhibitor activity|diazepam-binding inhibitor activity True http://purl.obolibrary.org/obo/GO_0008025 GO:0008024 biolink:CellularComponent cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. go.json positive transcription elongation factor complex b http://purl.obolibrary.org/obo/GO_0008024 GO:0008023 biolink:CellularComponent transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. go.json http://purl.obolibrary.org/obo/GO_0008023 goslim_pir GO:0008022 biolink:MolecularActivity obsolete protein C-terminus binding OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. go.json C-terminal binding|C-terminal end binding|COOH-terminal binding|COOH-terminus binding|carboxy-terminal binding|carboxy-terminus binding|carboxyl-terminal binding|carboxyl-terminus binding|carboxylate-terminal binding|carboxylate-terminus binding True http://purl.obolibrary.org/obo/GO_0008022 GO:0008021 biolink:CellularComponent synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. NIF_Subcellular:sao1071221672|Wikipedia:Synaptic_vesicle go.json docked vesicle http://purl.obolibrary.org/obo/GO_0008021 goslim_synapse GO:0008031 biolink:MolecularActivity eclosion hormone activity The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis. go.json http://purl.obolibrary.org/obo/GO_0008031 GO:0008030 biolink:MolecularActivity neuronal pentraxin receptor activity Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json neuronal pentaxin receptor http://purl.obolibrary.org/obo/GO_0008030 GO:0008039 biolink:BiologicalProcess synaptic target recognition The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses. go.json neuronal targeting http://purl.obolibrary.org/obo/GO_0008039 goslim_synapse GO:0008038 biolink:BiologicalProcess neuron recognition The process in which a neuronal cell in a multicellular organism interprets its surroundings. go.json neuronal cell recognition http://purl.obolibrary.org/obo/GO_0008038 GO:0008037 biolink:BiologicalProcess cell recognition The process in which a cell in an organism interprets its surroundings. go.json recognition of surroundings by cell http://purl.obolibrary.org/obo/GO_0008037 goslim_pir GO:0008036 biolink:MolecularActivity diuretic hormone receptor activity Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0008036 GO:0008035 biolink:MolecularActivity high-density lipoprotein particle binding Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. go.json HDL binding http://purl.obolibrary.org/obo/GO_0008035 GO:0008034 biolink:MolecularActivity obsolete lipoprotein binding OBSOLETE. Binding to a conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. go.json lipoprotein binding True http://purl.obolibrary.org/obo/GO_0008034 GO:0008033 biolink:BiologicalProcess tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. go.json tRNA maturation http://purl.obolibrary.org/obo/GO_0008033 goslim_yeast GO:0008032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008032 GO:0008042 biolink:MolecularActivity obsolete iron-sulfur electron transfer carrier OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system. go.json ferredoxin|iron-sulfur electron transfer carrier|iron-sulphur electron transfer carrier True http://purl.obolibrary.org/obo/GO_0008042 GO:0008041 biolink:MolecularActivity obsolete storage protein of fat body (sensu Insecta) OBSOLETE. (Was not defined before being made obsolete). go.json storage protein of fat body (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0008041 GO:0008040 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008040 GO:0008009 biolink:MolecularActivity chemokine activity The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. go.json http://purl.obolibrary.org/obo/GO_0008009 goslim_chembl GO:0008008 biolink:CellularComponent obsolete membrane attack complex protein beta2 chain OBSOLETE. (Was not defined before being made obsolete). go.json membrane attack complex protein beta2 chain True http://purl.obolibrary.org/obo/GO_0008008 GO:0008007 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008007 GO:0008006 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008006 GO:0008005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008005 GO:0008004 biolink:CellularComponent obsolete lamina reticularis OBSOLETE. A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue. go.json True http://purl.obolibrary.org/obo/GO_0008004 GO:0008003 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008003 GO:0008002 biolink:CellularComponent obsolete lamina lucida OBSOLETE. The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina. Wikipedia:Lamina_lucida go.json True http://purl.obolibrary.org/obo/GO_0008002 GO:0008001 biolink:MolecularActivity obsolete fibrinogen OBSOLETE. (Was not defined before being made obsolete). go.json fibrinogen True http://purl.obolibrary.org/obo/GO_0008001 GO:0008019 biolink:MolecularActivity obsolete macrophage receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json macrophage receptor activity True http://purl.obolibrary.org/obo/GO_0008019 GO:0008018 biolink:MolecularActivity obsolete structural protein of chorion (sensu Drosophila) OBSOLETE. (Was not defined before being made obsolete). go.json structural protein of chorion (sensu Drosophila) True http://purl.obolibrary.org/obo/GO_0008018 GO:0008017 biolink:MolecularActivity microtubule binding Binding to a microtubule, a filament composed of tubulin monomers. Reactome:R-HSA-9614343 go.json microtubule severing activity|microtubule/chromatin interaction http://purl.obolibrary.org/obo/GO_0008017 GO:0008016 biolink:BiologicalProcess regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. go.json regulation of cardiac contraction http://purl.obolibrary.org/obo/GO_0008016 GO:0008015 biolink:BiologicalProcess blood circulation The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. go.json hemolymph circulation http://purl.obolibrary.org/obo/GO_0008015 goslim_pir GO:0008014 biolink:MolecularActivity obsolete calcium-dependent cell adhesion molecule activity OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions. go.json cadherin|calcium-dependent cell adhesion molecule activity True http://purl.obolibrary.org/obo/GO_0008014 GO:0008013 biolink:MolecularActivity beta-catenin binding Binding to a catenin beta subunit. go.json http://purl.obolibrary.org/obo/GO_0008013 GO:0008012 biolink:MolecularActivity structural constituent of adult chitin-based cuticle The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster. go.json structural constituent of adult cuticle http://purl.obolibrary.org/obo/GO_0008012 GO:0008011 biolink:MolecularActivity structural constituent of pupal chitin-based cuticle The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster. go.json structural constituent of pupal cuticle http://purl.obolibrary.org/obo/GO_0008011 GO:0008010 biolink:MolecularActivity structural constituent of chitin-based larval cuticle The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster. go.json structural constituent of larval cuticle http://purl.obolibrary.org/obo/GO_0008010 GO:0008020 biolink:MolecularActivity G protein-coupled photoreceptor activity Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled photoreceptor activity|G-protein coupled photoreceptor activity|photoreceptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0008020 GO:0072573 biolink:BiologicalProcess tolerance induction to lipopolysaccharide Tolerance induction directed at lipopolysaccharide antigens. go.json tolerance induction to LPS|tolerance induction to endotoxin http://purl.obolibrary.org/obo/GO_0072573 GO:0072572 biolink:MolecularActivity poly-ADP-D-ribose binding Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. go.json pADPr binding|poly-ADP-ribose binding http://purl.obolibrary.org/obo/GO_0072572 GO:0072571 biolink:MolecularActivity mono-ADP-D-ribose binding Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. go.json mADPr binding|mono-ADP-ribose binding http://purl.obolibrary.org/obo/GO_0072571 GO:0072570 biolink:MolecularActivity ADP-D-ribose binding Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. go.json ADP-ribose binding http://purl.obolibrary.org/obo/GO_0072570 GO:0106313 biolink:MolecularActivity methylenetetrahydrofolate reductase NADPH activity Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+. RHEA:19817 go.json http://purl.obolibrary.org/obo/GO_0106313 GO:0106312 biolink:MolecularActivity methylenetetrahydrofolate reductase NADH activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+. RHEA:19821 go.json http://purl.obolibrary.org/obo/GO_0106312 GO:0106311 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106311 GO:0106310 biolink:MolecularActivity protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. RHEA:17989|Reactome:R-HSA-9729330|Reactome:R-HSA-9821967|Reactome:R-HSA-9821982 go.json protein-serine kinase activity http://purl.obolibrary.org/obo/GO_0106310 GO:0106317 biolink:MolecularActivity methane monooxygenase NADH activity Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O. EC:1.14.13.25|RHEA:13637 go.json http://purl.obolibrary.org/obo/GO_0106317 GO:0106316 biolink:MolecularActivity nitrite reductase NADH activity Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+. RHEA:24628 go.json http://purl.obolibrary.org/obo/GO_0106316 GO:0106314 biolink:MolecularActivity nitrite reductase NADPH activity Catalysis of the reaction: ammonium hydroxide + 3 NADP+ + H2O = nitrite + 3 NADPH + 3 H+. RHEA:24632 go.json http://purl.obolibrary.org/obo/GO_0106314 GO:0106319 biolink:MolecularActivity (R)-limonene 1,2-monooxygenase NADH activity Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide. EC:1.14.13.107|RHEA:26093 go.json http://purl.obolibrary.org/obo/GO_0106319 GO:0106318 biolink:MolecularActivity methane monooxygenase NADPH activity Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O. EC:1.14.13.25|RHEA:13641 go.json http://purl.obolibrary.org/obo/GO_0106318 GO:0072579 biolink:BiologicalProcess glycine receptor clustering The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane. go.json http://purl.obolibrary.org/obo/GO_0072579 GO:0072578 biolink:BiologicalProcess neurotransmitter-gated ion channel clustering The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane. go.json http://purl.obolibrary.org/obo/GO_0072578 GO:0072577 biolink:BiologicalProcess endothelial cell apoptotic process Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. go.json apoptosis of endothelial cells|endothelial cell apoptosis|endothelial cell programmed cell death by apoptosis|killing of endothelial cells|programmed cell death of endothelial cells by apoptosis|programmed cell death, endothelial cells http://purl.obolibrary.org/obo/GO_0072577 GO:0072576 biolink:BiologicalProcess liver morphogenesis The process in which the anatomical structures of the liver are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0072576 GO:0072575 biolink:BiologicalProcess epithelial cell proliferation involved in liver morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. go.json http://purl.obolibrary.org/obo/GO_0072575 GO:0072574 biolink:BiologicalProcess hepatocyte proliferation The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. go.json http://purl.obolibrary.org/obo/GO_0072574 GO:0072562 biolink:CellularComponent blood microparticle A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. go.json cell membrane microparticle http://purl.obolibrary.org/obo/GO_0072562 GO:0106320 biolink:MolecularActivity (R)-limonene 1,2-monooxygenase NADPH activity Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide. EC:1.14.13.107|RHEA:26097 go.json http://purl.obolibrary.org/obo/GO_0106320 GO:0072561 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072561 GO:0072560 biolink:BiologicalProcess type B pancreatic cell maturation A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. go.json pancreatic B cell maturation|pancreatic beta cell maturation http://purl.obolibrary.org/obo/GO_0072560 GO:0106324 biolink:MolecularActivity (S)-limonene 1,2-monooxygenase NADH activity Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide. RHEA:26089 go.json http://purl.obolibrary.org/obo/GO_0106324 GO:0106323 biolink:MolecularActivity (S)-limonene 1,2-monooxygenase NADPH activity Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide. RHEA:26085 go.json http://purl.obolibrary.org/obo/GO_0106323 GO:0106322 biolink:MolecularActivity S-(hydroxymethyl)glutathione dehydrogenase NAD activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+. EC:1.1.1.284|RHEA:19985 go.json http://purl.obolibrary.org/obo/GO_0106322 GO:0106321 biolink:MolecularActivity S-(hydroxymethyl)glutathione dehydrogenase NADP activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+. EC:1.1.1.284|RHEA:19981 go.json http://purl.obolibrary.org/obo/GO_0106321 GO:0106328 biolink:MolecularActivity acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP. EC:2.4.1.147|RHEA:46884 go.json http://purl.obolibrary.org/obo/GO_0106328 GO:0106327 biolink:MolecularActivity acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP. EC:2.4.1.147|RHEA:46880 go.json http://purl.obolibrary.org/obo/GO_0106327 GO:0106326 biolink:MolecularActivity acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP. EC:2.4.1.148|RHEA:56192 go.json http://purl.obolibrary.org/obo/GO_0106326 GO:0106325 biolink:MolecularActivity acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP. EC:2.4.1.148|RHEA:56188 go.json http://purl.obolibrary.org/obo/GO_0106325 GO:0106329 biolink:MolecularActivity L-phenylalaine oxidase activity Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+). RHEA:61240 go.json http://purl.obolibrary.org/obo/GO_0106329 GO:0072569 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072569 GO:0072568 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072568 GO:0072567 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 2 production The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL2 production|MIP-2 production|MIP2 production|SCYB2 production http://purl.obolibrary.org/obo/GO_0072567 gocheck_do_not_annotate GO:0072566 biolink:BiologicalProcess chemokine (C-X-C motif) ligand 1 production The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL1 production|KC production|SCYB1 production|keratinocyte derived chemokine production http://purl.obolibrary.org/obo/GO_0072566 gocheck_do_not_annotate GO:0072565 biolink:BiologicalProcess endothelial microparticle formation The cellular component organization process in which microparticles bud off from an endothelial cell. go.json endothelial microparticle generation|endothelial microparticle release http://purl.obolibrary.org/obo/GO_0072565 GO:0072564 biolink:BiologicalProcess blood microparticle formation The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. go.json microparticle generation|microparticle release http://purl.obolibrary.org/obo/GO_0072564 GO:0072563 biolink:CellularComponent endothelial microparticle A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0072563 GO:0072595 biolink:BiologicalProcess maintenance of protein localization in organelle Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. go.json maintenance of protein localisation to organelle|maintenance of protein localization to organelle http://purl.obolibrary.org/obo/GO_0072595 GO:0106331 biolink:MolecularActivity sialate 4-O-acetylesterase activity Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate. RHEA:25564 go.json http://purl.obolibrary.org/obo/GO_0106331 GO:0072594 biolink:BiologicalProcess establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. go.json establishment of protein localisation to organelle http://purl.obolibrary.org/obo/GO_0072594 GO:0106330 biolink:MolecularActivity sialate 9-O-acetylesterase activity Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate. RHEA:22600 go.json http://purl.obolibrary.org/obo/GO_0106330 GO:0072593 biolink:BiologicalProcess reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. go.json ROS metabolic process|reactive oxygen species metabolism http://purl.obolibrary.org/obo/GO_0072593 GO:0072592 biolink:BiologicalProcess oxygen metabolic process The chemical reactions and pathways involving diatomic oxygen (O2). go.json diatomic oxygen metabolic process|oxygen metabolism http://purl.obolibrary.org/obo/GO_0072592 GO:0106335 biolink:MolecularActivity tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.229|RHEA:43208 go.json http://purl.obolibrary.org/obo/GO_0106335 GO:0072591 biolink:MolecularActivity citrate-L-glutamate ligase activity Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. go.json http://purl.obolibrary.org/obo/GO_0072591 GO:0106334 biolink:MolecularActivity 3'-deoxyribose phosphate lyase activity Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate. RHEA:65764 go.json 3'-dRP lyase|3'-dRP lyase activity http://purl.obolibrary.org/obo/GO_0106334 GO:0072590 biolink:MolecularActivity N-acetyl-L-aspartate-L-glutamate ligase activity Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. Reactome:R-HSA-8942575 go.json http://purl.obolibrary.org/obo/GO_0072590 GO:0106333 biolink:CellularComponent subcortical maternal complex Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex. go.json SCMC http://purl.obolibrary.org/obo/GO_0106333 GO:0106332 biolink:MolecularActivity ds/ssDNA junction-specific dsDNA endonuclease activity Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction. go.json http://purl.obolibrary.org/obo/GO_0106332 GO:0106339 biolink:MolecularActivity tRNA (cytidine(32)-2'-O)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA. EC:2.1.1.205|MetaCyc:RXN-11866|RHEA:42396 go.json tRNA (cytidine 32-2'-O)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0106339 GO:0106336 biolink:BiologicalProcess yolk syncytial layer development The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm. go.json YSL development http://purl.obolibrary.org/obo/GO_0106336 GO:0072599 biolink:BiologicalProcess establishment of protein localization to endoplasmic reticulum The directed movement of a protein to a specific location in the endoplasmic reticulum. go.json establishment of protein localisation to ER|establishment of protein localisation to endoplasmic reticulum|establishment of protein localization in endoplasmic reticulum|establishment of protein localization to ER http://purl.obolibrary.org/obo/GO_0072599 GO:0072598 biolink:BiologicalProcess protein localization to chloroplast A process in which a protein is transported to, or maintained at, a location in a chloroplast. go.json protein localisation to chloroplast http://purl.obolibrary.org/obo/GO_0072598 GO:0072597 biolink:BiologicalProcess maintenance of protein location in chloroplast Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0072597 GO:0072596 biolink:BiologicalProcess establishment of protein localization to chloroplast The directed movement of a protein to a specific location in a chloroplast. go.json establishment of protein localisation to chloroplast http://purl.obolibrary.org/obo/GO_0072596 GO:0072584 biolink:BiologicalProcess caveolin-mediated endocytosis An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers. go.json caveolae-dependent endocytosis|caveolae-mediated endocytosis|caveolin-dependent endocytosis http://purl.obolibrary.org/obo/GO_0072584 GO:0106342 biolink:BiologicalProcess omega-hydroxyceramide biosynthetic process The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide. go.json http://purl.obolibrary.org/obo/GO_0106342 GO:0072583 biolink:BiologicalProcess clathrin-dependent endocytosis An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. go.json CME|clathrin coated pit-dependent endocytosis|clathrin-mediated endocytosis http://purl.obolibrary.org/obo/GO_0072583 GO:0106341 biolink:MolecularActivity omega-hydroxyceramide transacylase activity Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine. RHEA:55264 go.json http://purl.obolibrary.org/obo/GO_0106341 GO:0072582 biolink:MolecularActivity 17-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+. RHEA:69284 go.json http://purl.obolibrary.org/obo/GO_0072582 GO:0106340 biolink:MolecularActivity tRNA (guanine(34)-2'-O)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA. EC:2.1.1.205|MetaCyc:RXN-11868|RHEA:42396 go.json tRNA (guanosine 34-2'-O)-methyltransferase activity|tRNA (guanosine(34)-2'-O)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0106340 GO:0072581 biolink:BiologicalProcess protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P). go.json http://purl.obolibrary.org/obo/GO_0072581 gocheck_do_not_annotate GO:0106346 biolink:MolecularActivity snRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0106346 GO:0072580 biolink:BiologicalProcess bacterial-type EF-P lysine modification The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P). go.json EF-P modification pathway http://purl.obolibrary.org/obo/GO_0072580 gocheck_do_not_annotate GO:0106345 biolink:MolecularActivity glyoxylate reductase activity Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H. go.json http://purl.obolibrary.org/obo/GO_0106345 GO:0106344 biolink:MolecularActivity 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]. RHEA:65756 go.json http://purl.obolibrary.org/obo/GO_0106344 GO:0106343 biolink:MolecularActivity glutarate dioxygenase activity Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2. EC:1.14.11.64|RHEA:13821 go.json http://purl.obolibrary.org/obo/GO_0106343 GO:0106349 biolink:BiologicalProcess snRNA methylation The posttranscriptional addition of methyl groups to specific residues in an snRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0106349 GO:0106348 biolink:MolecularActivity U2 snRNA adenosine m6 methytransferase activity Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+. go.json http://purl.obolibrary.org/obo/GO_0106348 GO:0106347 biolink:MolecularActivity U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+. RHEA:62672 go.json http://purl.obolibrary.org/obo/GO_0106347 GO:0072589 biolink:CellularComponent box H/ACA scaRNP complex A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs. go.json nucleoplasmic box H/ACA RNP pseudouridylase complex http://purl.obolibrary.org/obo/GO_0072589 GO:0072588 biolink:CellularComponent box H/ACA RNP complex A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. go.json box H/ACA snoRNP pseudouridylase complex|sRNP complex http://purl.obolibrary.org/obo/GO_0072588 GO:0072587 biolink:MolecularActivity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. go.json http://purl.obolibrary.org/obo/GO_0072587 GO:0072586 biolink:MolecularActivity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. go.json http://purl.obolibrary.org/obo/GO_0072586 GO:0072585 biolink:MolecularActivity xanthosine nucleotidase activity Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine. MetaCyc:RXN0-363|RHEA:27994 go.json xanthosine ribohydrolase activity http://purl.obolibrary.org/obo/GO_0072585 GO:0106302 biolink:MolecularActivity arachidonic acid 8,9-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid. RHEA:64984 go.json http://purl.obolibrary.org/obo/GO_0106302 GO:0106301 biolink:MolecularActivity arachidonic acid 5,6-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid. RHEA:49936 go.json http://purl.obolibrary.org/obo/GO_0106301 GO:0106300 biolink:BiologicalProcess protein-DNA covalent cross-linking repair The removal of covalent cross-link between DNA and a protein. go.json resolution of protein-DNA covalent cross-linking http://purl.obolibrary.org/obo/GO_0106300 GO:0106306 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106306 GO:0106305 biolink:BiologicalProcess mannogen catabolic process The chemical reactions and pathways resulting in the breakdown of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. go.json beta-1,2-mannan catabolic process|beta-1,2-mannan catabolism|mannogen breakdown|mannogen catabolism|mannogen degradation http://purl.obolibrary.org/obo/GO_0106305 GO:0106304 biolink:BiologicalProcess mannogen biosynthetic process The chemical reactions and pathways resulting in the formation of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. go.json beta-1,2-mannan biosynthetic process|mannogen anabolism|mannogen biosynthesis|mannogen formation|mannogen synthesis http://purl.obolibrary.org/obo/GO_0106304 GO:0106303 biolink:BiologicalProcess mannogen metabolic process The chemical reactions and pathways involving mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. go.json beta-1,2-mannan metabolic process|mannogen metabolism http://purl.obolibrary.org/obo/GO_0106303 GO:0106309 biolink:MolecularActivity progesterone 21-hydroxylase activity Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. RHEA:50304 go.json http://purl.obolibrary.org/obo/GO_0106309 GO:0106307 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106307 GO:0106397 biolink:BiologicalProcess positive regulation of R7 cell fate commitment Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment. go.json http://purl.obolibrary.org/obo/GO_0106397 GO:0106396 biolink:BiologicalProcess regulation of R7 cell fate commitment Any process that modulates the frequency, rate or extent of R7 cell fate commitment. go.json http://purl.obolibrary.org/obo/GO_0106396 GO:0106395 biolink:BiologicalProcess positive regulation of palmitic acid catabolic process Any process that activates or increases the frequency, rate or extent of a palmitic acid catabolic process. go.json http://purl.obolibrary.org/obo/GO_0106395 GO:0106394 biolink:BiologicalProcess negative regulation of palmitic acid catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of a palmitic acid catabolic process. go.json http://purl.obolibrary.org/obo/GO_0106394 GO:0106399 biolink:MolecularActivity acyl-coenzyme A diphosphatase activity Catalysis of the reaction: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. RHEA:50044|Reactome:R-HSA-9837354 go.json http://purl.obolibrary.org/obo/GO_0106399 GO:0106398 biolink:BiologicalProcess negative regulation of R7 cell fate commitment Any process that stops, prevents or reduces the frequency, rate or extent of R7 cell fate commitment. go.json http://purl.obolibrary.org/obo/GO_0106398 GO:0047537 biolink:MolecularActivity 2-aminohexanoate transaminase activity Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate. EC:2.6.1.67|MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN|RHEA:23600 go.json 2-aminohexanoate aminotransferase activity|L-2-aminohexanoate:2-oxoglutarate aminotransferase activity|leucine L-norleucine: 2-oxoglutarate aminotransferase activity|norleucine (leucine) aminotransferase activity|norleucine aminotransferase activity|norleucine transaminase activity http://purl.obolibrary.org/obo/GO_0047537 GO:0047536 biolink:MolecularActivity 2-aminoadipate transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate. EC:2.6.1.39|KEGG_REACTION:R01939|MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN|RHEA:12601|Reactome:R-HSA-508561|Reactome:R-HSA-70952 go.json 2-aminoadipate aminotransferase activity|2-aminoadipic aminotransferase activity|L-2-aminoadipate:2-oxoglutarate aminotransferase activity|alpha-aminoadipate aminotransferase activity|glutamate-alpha-ketoadipate transaminase activity|glutamic-ketoadipic transaminase activity http://purl.obolibrary.org/obo/GO_0047536 GO:0047535 biolink:MolecularActivity 2-alkyn-1-ol dehydrogenase activity Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + H+ + NADH. EC:1.1.1.165|KEGG_REACTION:R03963|MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN|RHEA:19101 go.json 2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047535 GO:0047534 biolink:MolecularActivity 2-acetolactate mutase activity Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate. EC:5.4.99.3|MetaCyc:2-ACETOLACTATE-MUTASE-RXN|RHEA:16361 go.json 2-acetolactate methylmutase activity|acetohydroxy acid isomerase activity|acetolactate mutase activity http://purl.obolibrary.org/obo/GO_0047534 GO:0047533 biolink:MolecularActivity 2,5-dioxovalerate dehydrogenase (NADP+) activity Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+. EC:1.2.1.26|MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN|RHEA:11296 go.json 2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity|2-oxoglutarate semialdehyde dehydrogenase activity|alpha-ketoglutaric semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047533 GO:0047532 biolink:MolecularActivity 2,5-dioxopiperazine hydrolase activity Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine. EC:3.5.2.13|KEGG_REACTION:R03810|MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN|RHEA:21808 go.json 2,5-dioxopiperazine amidohydrolase activity|cyclo(Gly-Gly) hydrolase activity|cyclo(glycylglycine) hydrolase activity http://purl.obolibrary.org/obo/GO_0047532 GO:0047531 biolink:MolecularActivity obsolete 2,5-diaminovalerate transaminase activity OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate. go.json 2,5-diaminovalerate aminotransferase activity True http://purl.obolibrary.org/obo/GO_0047531 GO:0047530 biolink:MolecularActivity 2,4-diaminopentanoate dehydrogenase activity Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+. EC:1.4.1.12|MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN go.json 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)|2,4-diaminopentanoic acid C4 dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047530 GO:0047539 biolink:MolecularActivity 2-deoxyglucosidase activity Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol. EC:3.2.1.112|MetaCyc:2-DEOXYGLUCOSIDASE-RXN|RHEA:15317 go.json 2-deoxy-alpha-D-glucosidase activity|2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity|2-deoxy-alpha-glucosidase activity http://purl.obolibrary.org/obo/GO_0047539 GO:0047538 biolink:MolecularActivity 2-carboxy-D-arabinitol-1-phosphatase activity Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate. EC:3.1.3.63|KEGG_REACTION:R04167|MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN|RHEA:17837 go.json 2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity|2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity|2-carboxyarabinitol 1-phosphatase activity http://purl.obolibrary.org/obo/GO_0047538 GO:0047540 biolink:MolecularActivity 2-enoate reductase activity Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+. EC:1.3.1.31|MetaCyc:2-ENOATE-REDUCTASE-RXN|RHEA:10200 go.json butanoate:NAD+ delta2-oxidoreductase activity|enoate reductase activity http://purl.obolibrary.org/obo/GO_0047540 GO:0047548 biolink:MolecularActivity 2-methyleneglutarate mutase activity Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate. EC:5.4.99.4|KEGG_REACTION:R03908|MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN|RHEA:13793 go.json 2-methyleneglutarate carboxy-methylenemethylmutase activity|alpha-methyleneglutarate mutase activity http://purl.obolibrary.org/obo/GO_0047548 GO:0047547 biolink:MolecularActivity 2-methylcitrate dehydratase activity Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H2O. EC:4.2.1.79|KEGG_REACTION:R04424|MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN|RHEA:17725 go.json (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]|2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity|2-methylcitrate hydro-lyase activity|prpD http://purl.obolibrary.org/obo/GO_0047547 GO:0047546 biolink:MolecularActivity 2-hydroxypyridine 5-monooxygenase activity Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O2 = 2,5-dihydroxypyridine + A + H2O. EC:1.14.99.26|KEGG_REACTION:R03206|MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN|RHEA:16973 go.json 2-hydroxypyridine oxygenase activity|2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating) http://purl.obolibrary.org/obo/GO_0047546 GO:0047545 biolink:MolecularActivity 2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. EC:1.1.99.2|MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN|RHEA:21252|Reactome:R-HSA-880050 go.json (S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase|(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase|L-alpha-hydroxyglutarate dehydrogenase activity|L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase|alpha-hydroxyglutarate dehydrogenase (NAD+ specific)|alpha-hydroxyglutarate dehydrogenase activity|alpha-hydroxyglutarate oxidoreductase activity|hydroxyglutaric dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047545 GO:0047544 biolink:MolecularActivity 2-hydroxybiphenyl 3-monooxygenase activity Catalysis of the reaction: biphenyl-2-ol + H+ + NADH + O2 = biphenyl-2,3-diol + H2O + NAD+. EC:1.14.13.44|KEGG_REACTION:R03964|MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN|RHEA:11996|UM-BBD_reactionID:r1423 go.json 2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating) http://purl.obolibrary.org/obo/GO_0047544 GO:0047543 biolink:MolecularActivity 2-hexadecenal reductase activity Catalysis of the reaction: NADP+ + palmitaldehyde = trans-hexadec-2-enal + H+ + NADPH. EC:1.3.1.27|KEGG_REACTION:R02463|MetaCyc:2-HEXADECENAL-REDUCTASE-RXN|RHEA:12444 go.json hexadecanal: NADP+ oxidoreductase activity|hexadecanal:NADP+ delta2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047543 GO:0047542 biolink:MolecularActivity 2-furoyl-CoA dehydrogenase activity Catalysis of the reaction: 2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH(2) + H+. EC:1.3.99.8|KEGG_REACTION:R02987|MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN|RHEA:21480 go.json 2-furoyl coenzyme A dehydrogenase activity|2-furoyl coenzyme A hydroxylase activity|2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)|2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)|furoyl-CoA hydroxylase activity http://purl.obolibrary.org/obo/GO_0047542 GO:0047541 biolink:MolecularActivity 2-furoate-CoA ligase activity Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H+. EC:6.2.1.31|KEGG_REACTION:R02986|MetaCyc:2-FUROATE--COA-LIGASE-RXN|RHEA:19269 go.json 2-furoate:CoA ligase (AMP-forming)|2-furoyl coenzyme A synthetase activity http://purl.obolibrary.org/obo/GO_0047541 GO:0047549 biolink:MolecularActivity 2-nitrophenol 2-monooxygenase activity Catalysis of the reaction: 2-nitrophenol + 2 H+ + 2 NADPH + O2 = catechol + H2O + 2 NADP+ + nitrite. EC:1.14.13.31|KEGG_REACTION:R00828|MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN|RHEA:19457|UM-BBD_reactionID:r1494 go.json 2-nitrophenol oxygenase activity|2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)|nitrophenol oxygenase activity http://purl.obolibrary.org/obo/GO_0047549 GO:0047551 biolink:MolecularActivity 2-oxoaldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+. EC:1.2.1.23|MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN|RHEA:22276|Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+) go.json 2-ketoaldehyde dehydrogenase|2-oxoaldehyde dehydrogenase (NAD+)|2-oxoaldehyde:NAD+ 2-oxidoreductase activity|NAD-dependent alpha-ketoaldehyde dehydrogenase activity|NAD-linked alpha-ketoaldehyde dehydrogenase activity|alpha-ketoaldehyde dehydrogenase activity|methylglyoxal dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047551 GO:0047550 biolink:MolecularActivity 2-oxoadipate reductase activity Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + H+ + NADH. EC:1.1.1.172|KEGG_REACTION:R01932|MetaCyc:2-OXOADIPATE-REDUCTASE-RXN|RHEA:14793 go.json 2-hydroxyadipate:NAD+ 2-oxidoreductase activity|2-ketoadipate reductase activity|alpha-ketoadipate reductase activity http://purl.obolibrary.org/obo/GO_0047550 GO:0047559 biolink:MolecularActivity 3-dehydro-L-gulonate 2-dehydrogenase activity Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+. EC:1.1.1.130|MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN go.json 2,3-diketo-L-gulonate reductase activity|3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity|3-keto-L-gulonate dehydrogenase activity|3-ketogulonate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047559 GO:0047558 biolink:MolecularActivity 3-cyanoalanine hydratase activity Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H2O + H+. EC:4.2.1.65|KEGG_REACTION:R01267|MetaCyc:3-CYANOALANINE-HYDRATASE-RXN|RHEA:15385 go.json L-asparagine hydro-lyase (3-cyanoalanine-forming)|L-asparagine hydro-lyase activity|beta-CNA nitrilase activity|beta-CNAla hydrolase activity|beta-cyanoalanine hydratase activity|beta-cyanoalanine hydrolase activity http://purl.obolibrary.org/obo/GO_0047558 GO:0047557 biolink:MolecularActivity 3-aci-nitropropanoate oxidase activity Catalysis of the reaction: 3-aci-nitropropanoate + H2O + O2 = 3-oxopropanoate + H2O2 + nitrite. EC:1.7.3.5|KEGG_REACTION:R01609|MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN|RHEA:22372 go.json 3-aci-nitropropanoate:oxygen oxidoreductase activity|propionate-3-nitronate oxidase activity http://purl.obolibrary.org/obo/GO_0047557 GO:0047556 biolink:MolecularActivity 3,4-dihydroxyphthalate decarboxylase activity Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2. EC:4.1.1.69|KEGG_REACTION:R01634|MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN|RHEA:18601|UM-BBD_reactionID:r1447 go.json 3,4-dihydroxyphthalate 2-decarboxylase activity|3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)|3,4-dihydroxyphthalate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047556 GO:0047555 biolink:MolecularActivity 3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. EC:3.1.4.35|MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN|RHEA:16957|Reactome:R-HSA-4086392|Reactome:R-HSA-418456|Reactome:R-HSA-74059 go.json 3',5' cyclic-GMP phosphodiesterase activity|3',5'-cyclic-GMP 5'-nucleotidohydrolase activity|cGMP phosphodiesterase activity|cGMP-PDE|cGMP-specific phosphodiesterase activity|cyclic 3',5'-GMP phosphodiesterase activity|cyclic GMP phosphodiesterase activity|cyclic guanosine 3',5'-monophosphate phosphodiesterase activity|cyclic guanosine 3',5'-phosphate phosphodiesterase activity|guanosine cyclic 3',5'-phosphate phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0047555 GO:0047554 biolink:MolecularActivity 2-pyrone-4,6-dicarboxylate lactonase activity Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H+. EC:3.1.1.57|KEGG_REACTION:R04277|MetaCyc:RXN-2462|RHEA:10644 go.json 2-pyrone-4,6-dicarboxylate lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0047554 GO:0047553 biolink:MolecularActivity 2-oxoglutarate synthase activity Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin. EC:1.2.7.3|MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN|RHEA:17297 go.json 2-ketoglutarate ferredoxin oxidoreductase activity|2-oxoglutarate ferredoxin oxidoreductase activity|2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)|2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)|2-oxoglutarate:ferredoxin oxidoreductase activity|KGOR activity|alpha-ketoglutarate synthase activity|alpha-ketoglutarate-ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047553 GO:0047552 biolink:MolecularActivity 2-oxoaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+. EC:1.2.1.49|MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN|RHEA:18129 go.json 2-ketoaldehyde dehydrogenase|2-oxoaldehyde:NADP+ 2-oxidoreductase activity|NADP-dependent alpha-ketoaldehyde dehydrogenase activity|NADP-linked alpha-ketoaldehyde dehydrogenase activity|alpha-ketoaldehyde dehydrogenase activity|methylglyoxal dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047552 GO:0072519 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072519 GO:0072518 biolink:MolecularActivity Rho-dependent protein serine/threonine kinase activity Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. go.json ROCK kinase activity|Rho-associated protein kinase activity http://purl.obolibrary.org/obo/GO_0072518 GO:0072517 biolink:CellularComponent host cell viral assembly compartment A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place. go.json host cell viral assembly site|host cell virion assembly compartment|viral assembly compartment|viral assembly site|virion assembly compartment http://purl.obolibrary.org/obo/GO_0072517 GO:0072516 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072516 GO:0072515 biolink:BiologicalProcess trehalose transport in response to desiccation The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water. go.json http://purl.obolibrary.org/obo/GO_0072515 GO:0072514 biolink:BiologicalProcess trehalose transport in response to water deprivation The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water. go.json http://purl.obolibrary.org/obo/GO_0072514 GO:0072513 biolink:BiologicalProcess positive regulation of secondary heart field cardioblast proliferation Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). go.json negative regulation of second heart field cardioblast proliferation http://purl.obolibrary.org/obo/GO_0072513 GO:0072512 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072512 GO:0072511 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072511 GO:0072510 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072510 GO:0047562 biolink:MolecularActivity 3-hydroxyaspartate aldolase activity Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate. EC:4.1.3.14|KEGG_REACTION:R00478|MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN|RHEA:14377 go.json erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity|erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)|erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity|erythro-beta-hydroxyaspartate aldolase activity|erythro-beta-hydroxyaspartate glycine-lyase activity http://purl.obolibrary.org/obo/GO_0047562 GO:0047561 biolink:MolecularActivity 3-hydroxyanthranilate oxidase activity Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2. EC:1.10.3.5|KEGG_REACTION:R02666|MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN|RHEA:17245 go.json 3-hydroxyanthranilate:oxygen oxidoreductase activity|3-hydroxyanthranilic acid oxidase activity http://purl.obolibrary.org/obo/GO_0047561 GO:0047560 biolink:MolecularActivity 3-dehydrosphinganine reductase activity Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH. EC:1.1.1.102|KEGG_REACTION:R02978|MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN|RHEA:22640|Reactome:R-HSA-428123 go.json 3-ketosphinganine reductase activity|3-oxosphinganine reductase activity|3-oxosphinganine:NADPH oxidoreductase activity|D-3-dehydrosphinganine reductase activity|D-3-oxosphinganine reductase activity|D-3-oxosphinganine:B-NADPH oxidoreductase activity|D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity|DSR activity|KTS reductase activity http://purl.obolibrary.org/obo/GO_0047560 GO:0047569 biolink:MolecularActivity 3-oxoadipate CoA-transferase activity Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. EC:2.8.3.6|MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN|RHEA:12048|UM-BBD_reactionID:r1050 go.json 3-oxoadipate coenzyme A-transferase activity|3-oxoadipate succinyl-CoA transferase activity|beta-ketoadipate:succinyl-CoA transferase activity|succinyl-CoA:3-oxoadipate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0047569 GO:0047568 biolink:MolecularActivity 3-oxo-5-beta-steroid 4-dehydrogenase activity Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor. EC:1.3.99.6|MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN|RHEA:24172 go.json 3-oxo-5beta-steroid 4-dehydrogenase activity|3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity|3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity|delta4-3-ketosteroid 5-beta-reductase activity http://purl.obolibrary.org/obo/GO_0047568 GO:0047567 biolink:MolecularActivity 3-methyleneoxindole reductase activity Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + H+ + NADPH. EC:1.3.1.17|KEGG_REACTION:R03930|MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN|RHEA:20257 go.json 3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity|3-methyloxindole:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047567 GO:0047566 biolink:MolecularActivity 3-ketovalidoxylamine C-N-lyase activity Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H+. EC:4.3.3.1|KEGG_REACTION:R04367|MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN|RHEA:22768 go.json 3-ketovalidoxylamine A C-N-lyase activity|4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]|4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity|p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity http://purl.obolibrary.org/obo/GO_0047566 GO:0047565 biolink:MolecularActivity 3-hydroxypropionate dehydrogenase (NAD+) activity Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + H+ + NADH. EC:1.1.1.59|KEGG_REACTION:R01608|MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN|RHEA:13357 go.json 3-hydroxypropanoate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047565 GO:0047564 biolink:MolecularActivity 3-hydroxycyclohexanone dehydrogenase activity Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione. EC:1.1.99.26|KEGG_REACTION:R03212|MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN|RHEA:15905 go.json 3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047564 GO:0047563 biolink:MolecularActivity 3-hydroxybenzoate 2-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O2 = 2,3-dihydroxybenzoate + A + H2O. EC:1.14.99.23|KEGG_REACTION:R01508|MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN|RHEA:14193 go.json 3-HBA-2-hydroxylase activity|3-hydroxybenzoate 2-hydroxylase activity|3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating) http://purl.obolibrary.org/obo/GO_0047563 GO:0072509 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072509 GO:0072508 biolink:BiologicalProcess obsolete trivalent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0072508 GO:0072507 biolink:BiologicalProcess obsolete divalent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0072507 GO:0072506 biolink:BiologicalProcess obsolete trivalent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0072506 GO:0072505 biolink:BiologicalProcess obsolete divalent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0072505 GO:0072504 biolink:BiologicalProcess obsolete cellular trivalent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell. go.json True http://purl.obolibrary.org/obo/GO_0072504 GO:0072503 biolink:BiologicalProcess obsolete cellular divalent inorganic cation homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell. go.json True http://purl.obolibrary.org/obo/GO_0072503 GO:0072502 biolink:BiologicalProcess obsolete cellular trivalent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell. go.json True http://purl.obolibrary.org/obo/GO_0072502 GO:0072501 biolink:BiologicalProcess obsolete cellular divalent inorganic anion homeostasis OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell. go.json True http://purl.obolibrary.org/obo/GO_0072501 GO:0072500 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor True http://purl.obolibrary.org/obo/GO_0072500 GO:0047573 biolink:MolecularActivity 4-acetamidobutyrate deacetylase activity Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate. EC:3.5.1.63|MetaCyc:RXN-36|RHEA:15897 go.json 4-acetamidobutanoate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047573 GO:0047572 biolink:MolecularActivity 3-phosphoglycerate phosphatase activity Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate. EC:3.1.3.38|KEGG_REACTION:R01511|MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN|RHEA:12412 go.json 3-PGA phosphatase activity|D-3-phosphoglycerate phosphatase activity|D-glycerate-3-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047572 GO:0106352 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106352 GO:0106351 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106351 GO:0047571 biolink:MolecularActivity 3-oxosteroid 1-dehydrogenase activity Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor. EC:1.3.99.4|MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN|RHEA:13329|UM-BBD_enzymeID:e0712 go.json 1-ene-dehydrogenase activity|3-ketosteroid-1-en-dehydrogenase activity|3-ketosteroid-delta1-dehydrogenase activity|3-oxosteroid delta1-dehydrogenase activity|3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity|3-oxosteroid:(acceptor) delta1-oxidoreductase activity|3-oxosteroid:acceptor delta1-oxidoreductase activity|4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity|delta1-dehydrogenase activity|delta1-steroid reductase activity http://purl.obolibrary.org/obo/GO_0047571 GO:0106350 biolink:MolecularActivity octaprenyl pyrophosphate synthase activity Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate. EC:2.5.1.90|RHEA:27798 go.json http://purl.obolibrary.org/obo/GO_0106350 GO:0047570 biolink:MolecularActivity 3-oxoadipate enol-lactonase activity Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. EC:3.1.1.24|MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN|RHEA:10184 go.json 3-ketoadipate enol-lactonase activity|3-oxoadipic enol-lactone hydrolase activity|4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity|beta-ketoadipate enol-lactone hydrolase activity|beta-ketoadipic enol-lactone hydrolase activity|carboxymethylbutenolide lactonase activity http://purl.obolibrary.org/obo/GO_0047570 GO:0106357 biolink:MolecularActivity glycerol-1-phosphate dehydrogenase [NAD+] activity Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH. RHEA:21412 go.json http://purl.obolibrary.org/obo/GO_0106357 GO:0106356 biolink:MolecularActivity 4-hydroxybenzoate 3-monooxygenase [NADPH] activity Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+. RHEA:19477 go.json http://purl.obolibrary.org/obo/GO_0106356 GO:0106355 biolink:MolecularActivity 4-hydroxybenzoate 3-monooxygenase [NADH] activity Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+. RHEA:19473 go.json http://purl.obolibrary.org/obo/GO_0106355 GO:0106354 biolink:BiologicalProcess tRNA surveillance The set of processes involved in identifying and degrading defective or aberrant tRNAs. go.json http://purl.obolibrary.org/obo/GO_0106354 GO:0047579 biolink:MolecularActivity 4-hydroxymandelate oxidase activity Catalysis of the reaction: (S)-4-hydroxymandelate + H+ + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2. EC:1.1.3.19|KEGG_REACTION:R02673|MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN|RHEA:15833 go.json (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity|L-4-hydroxymandelate oxidase (decarboxylating) http://purl.obolibrary.org/obo/GO_0047579 GO:0106359 biolink:MolecularActivity 2-hydroxyacyl-CoA lyase activity Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA. EC:4.1.2.63|MetaCyc:RXN66-471 go.json http://purl.obolibrary.org/obo/GO_0106359 GO:0047578 biolink:MolecularActivity 4-hydroxyglutamate transaminase activity Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate. EC:2.6.1.23|MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN|RHEA:10480|Reactome:R-HSA-6784393 go.json 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity|4-hydroxyglutamate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047578 GO:0106358 biolink:MolecularActivity glycerol-1-phosphate dehydrogenase [NADP+] activity Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH. RHEA:21416 go.json http://purl.obolibrary.org/obo/GO_0106358 GO:0047577 biolink:MolecularActivity 4-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = H+ + NADH + succinate semialdehyde. EC:1.1.1.61|KEGG_REACTION:R01644|MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN|RHEA:23948 go.json 4-hydroxybutanoate:NAD+ oxidoreductase activity|gamma-hydroxybutyrate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047577 GO:0047576 biolink:MolecularActivity 4-chlorobenzoate dehalogenase activity Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+. EC:3.8.1.6|KEGG_REACTION:R01307|MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN|RHEA:23440 go.json 4-chlorobenzoate chlorohydrolase activity|halobenzoate dehalogenase activity http://purl.obolibrary.org/obo/GO_0047576 GO:0047575 biolink:MolecularActivity 4-carboxymuconolactone decarboxylase activity Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2. EC:4.1.1.44|KEGG_REACTION:R03470|MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN|RHEA:23348 go.json 4-carboxymonolactone carboxy-lyase activity|4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)|4-carboxymuconolactone carboxy-lyase activity|gamma-4-carboxymuconolactone decarboxylase activity http://purl.obolibrary.org/obo/GO_0047575 GO:0047574 biolink:MolecularActivity 4-acetamidobutyryl-CoA deacetylase activity Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate. EC:3.5.1.51|KEGG_REACTION:R04056|MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN|RHEA:22928 go.json 4-acetamidobutanoyl-CoA amidohydrolase activity|aminobutyryl-CoA thiolesterase activity|deacetylase-thiolesterase activity http://purl.obolibrary.org/obo/GO_0047574 GO:0072539 biolink:BiologicalProcess T-helper 17 cell differentiation The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. go.json T-helper 17 cell development http://purl.obolibrary.org/obo/GO_0072539 GO:0072538 biolink:BiologicalProcess T-helper 17 type immune response An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22. go.json Th17 immune response http://purl.obolibrary.org/obo/GO_0072538 GO:0072537 biolink:BiologicalProcess fibroblast activation A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. go.json http://purl.obolibrary.org/obo/GO_0072537 GO:0072536 biolink:CellularComponent interleukin-23 receptor complex A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. go.json IL-23 receptor complex http://purl.obolibrary.org/obo/GO_0072536 GO:0072535 biolink:BiologicalProcess tumor necrosis factor (ligand) superfamily member 11 production The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json RANKL production|TNFSF11 production|tumor necrosis factor ligand superfamily member 11 production http://purl.obolibrary.org/obo/GO_0072535 gocheck_do_not_annotate GO:0072534 biolink:CellularComponent perineuronal net A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain. go.json PNN http://purl.obolibrary.org/obo/GO_0072534 GO:0106360 biolink:MolecularActivity obsolete 2-hydroxy-3-methylhexadecanoyl-CoA lyase activity OBSOLETE. Catalysis of the reaction: 2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA. go.json True http://purl.obolibrary.org/obo/GO_0106360 GO:0072533 biolink:MolecularActivity tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives. go.json http://purl.obolibrary.org/obo/GO_0072533 GO:0072532 biolink:MolecularActivity tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives. go.json http://purl.obolibrary.org/obo/GO_0072532 GO:0072531 biolink:BiologicalProcess pyrimidine-containing compound transmembrane transport The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. go.json pyrimidine-containing compound membrane transport http://purl.obolibrary.org/obo/GO_0072531 GO:0072530 biolink:BiologicalProcess purine-containing compound transmembrane transport The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof. go.json purine-containing compound membrane transport http://purl.obolibrary.org/obo/GO_0072530 GO:0106364 biolink:MolecularActivity 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. RHEA:20361 go.json http://purl.obolibrary.org/obo/GO_0106364 GO:0047584 biolink:MolecularActivity 4-oxalmesaconate hydratase activity Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O. EC:4.2.1.83|KEGG_REACTION:R04478|MetaCyc:RXN-2463|RHEA:17401 go.json 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]|2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity|4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity|4-carboxy-2-oxohexenedioate hydratase activity|gamma-oxalmesaconate hydratase activity|oxalmesaconate hydratase activity http://purl.obolibrary.org/obo/GO_0047584 GO:0106363 biolink:MolecularActivity protein-cysteine methyltransferase activity Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]. RHEA:66544 go.json protein cysteine methylase activity|protein cysteine methyltransferase activity http://purl.obolibrary.org/obo/GO_0106363 GO:0047583 biolink:MolecularActivity 4-methyloxaloacetate esterase activity Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H2O = H+ + methanol + oxaloacetate. EC:3.1.1.44|KEGG_REACTION:R01144|MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN|RHEA:10564 go.json oxaloacetate-4-methyl-ester oxaloacetohydrolase activity http://purl.obolibrary.org/obo/GO_0047583 GO:0106362 biolink:MolecularActivity protein-arginine N-acetylglucosaminyltransferase activity Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP. RHEA:66632 go.json http://purl.obolibrary.org/obo/GO_0106362 GO:0047582 biolink:MolecularActivity 4-methyleneglutaminase activity Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4. EC:3.5.1.67|KEGG_REACTION:R02712|MetaCyc:4-METHYLENEGLUTAMINASE-RXN|RHEA:14741 go.json 4-methylene-L-glutamine amidohydrolase activity|4-methyleneglutamine amidohydrolase activity|4-methyleneglutamine deamidase activity http://purl.obolibrary.org/obo/GO_0047582 GO:0106361 biolink:MolecularActivity protein-arginine rhamnosyltransferase activity Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]. RHEA:66692 go.json http://purl.obolibrary.org/obo/GO_0106361 GO:0047581 biolink:MolecularActivity 4-methyleneglutamate-ammonia ligase activity Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH4 = 4-methylene-L-glutamine + AMP + diphosphate + 2 H+. EC:6.3.1.7|KEGG_REACTION:R02711|MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN|RHEA:13853 go.json 4-methylene-L-glutamate:ammonia ligase (AMP-forming)|4-methyleneglutamine synthetase activity http://purl.obolibrary.org/obo/GO_0047581 GO:0106368 biolink:MolecularActivity (deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP. RHEA:62132 go.json http://purl.obolibrary.org/obo/GO_0106368 GO:0047580 biolink:MolecularActivity 4-hydroxyproline epimerase activity Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline. EC:5.1.1.8|KEGG_REACTION:R03296|MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN|RHEA:21152 go.json 4-hydroxyproline 2-epimerase activity|L-hydroxyproline epimerase activity|hydroxyproline 2-epimerase activity|hydroxyproline epimerase activity http://purl.obolibrary.org/obo/GO_0047580 GO:0106367 biolink:MolecularActivity (deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP. RHEA:62128 go.json http://purl.obolibrary.org/obo/GO_0106367 GO:0106366 biolink:MolecularActivity guanosine kinase activity Catalysis of the reaction: ATP + guanosine = ADP + GMP. EC:2.7.1.73|RHEA:27710 go.json http://purl.obolibrary.org/obo/GO_0106366 GO:0106365 biolink:MolecularActivity beta-carotene isomerase activity Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene. EC:5.2.1.14|RHEA:34455 go.json http://purl.obolibrary.org/obo/GO_0106365 GO:0106369 biolink:MolecularActivity (deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP. RHEA:62124 go.json http://purl.obolibrary.org/obo/GO_0106369 GO:0047589 biolink:MolecularActivity 5-aminovalerate transaminase activity Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate. EC:2.6.1.48|KEGG_REACTION:R02274|MetaCyc:VAGL-RXN|RHEA:10212 go.json 5-aminopentanoate:2-oxoglutarate aminotransferase activity|5-aminovalerate aminotransferase activity|delta-aminovalerate aminotransferase activity|delta-aminovalerate transaminase activity http://purl.obolibrary.org/obo/GO_0047589 GO:0047588 biolink:MolecularActivity 5-aminopentanamidase activity Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. EC:3.5.1.30|MetaCyc:5-AMINOPENTANAMIDASE-RXN|RHEA:15677 go.json 5-aminonorvaleramidase activity|5-aminopentanamide amidohydrolase activity|5-aminovaleramidase activity http://purl.obolibrary.org/obo/GO_0047588 GO:0047587 biolink:MolecularActivity 5-alpha-hydroxysteroid dehydratase activity Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O. EC:4.2.1.62|KEGG_REACTION:R03675|MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN|RHEA:22064 go.json 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)|5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity|5alpha-hydroxysteroid dehydratase activity http://purl.obolibrary.org/obo/GO_0047587 GO:0047586 biolink:MolecularActivity 5'-acylphosphoadenosine hydrolase activity Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate. EC:3.6.1.20|MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN|RHEA:16837 go.json 5'-acylphosphoadenosine acylhydrolase activity|5-phosphoadenosine hydrolase activity http://purl.obolibrary.org/obo/GO_0047586 GO:0047585 biolink:MolecularActivity 4-pyridoxolactonase activity Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate + H+. EC:3.1.1.27|KEGG_REACTION:R02992|MetaCyc:4-PYRIDOXOLACTONASE-RXN|RHEA:14301 go.json 4-pyridoxolactone lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0047585 GO:0072529 biolink:BiologicalProcess pyrimidine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. go.json pyrimidine and derivative catabolic process|pyrimidine-containing compound breakdown|pyrimidine-containing compound catabolism|pyrimidine-containing compound degradation http://purl.obolibrary.org/obo/GO_0072529 GO:0072528 biolink:BiologicalProcess pyrimidine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. go.json pyrimidine and derivative biosynthetic process|pyrimidine-containing compound anabolism|pyrimidine-containing compound biosynthesis|pyrimidine-containing compound formation|pyrimidine-containing compound synthesis http://purl.obolibrary.org/obo/GO_0072528 GO:0072527 biolink:BiologicalProcess pyrimidine-containing compound metabolic process The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. go.json pyrimidine and derivative metabolic process|pyrimidine-containing compound metabolism http://purl.obolibrary.org/obo/GO_0072527 GO:0072526 biolink:BiologicalProcess pyridine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. go.json pyridine and derivative catabolic process|pyridine-containing compound breakdown|pyridine-containing compound catabolism|pyridine-containing compound degradation http://purl.obolibrary.org/obo/GO_0072526 GO:0072525 biolink:BiologicalProcess pyridine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. go.json pyridine and derivative biosynthetic process|pyridine-containing compound anabolism|pyridine-containing compound biosynthesis|pyridine-containing compound formation|pyridine-containing compound synthesis http://purl.obolibrary.org/obo/GO_0072525 GO:0072524 biolink:BiologicalProcess pyridine-containing compound metabolic process The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. go.json pyridine and derivative metabolic process|pyridine-containing compound metabolism http://purl.obolibrary.org/obo/GO_0072524 GO:0072523 biolink:BiologicalProcess purine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. go.json purine and derivative catabolic process|purine-containing compound breakdown|purine-containing compound catabolism|purine-containing compound degradation http://purl.obolibrary.org/obo/GO_0072523 GO:0072522 biolink:BiologicalProcess purine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. go.json purine and derivative biosynthetic process|purine-containing compound anabolism|purine-containing compound biosynthesis|purine-containing compound formation|purine-containing compound synthesis http://purl.obolibrary.org/obo/GO_0072522 GO:0106371 biolink:MolecularActivity fluorescent chlorophyll catabolite monooxygenase (deformylase) activity Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite. RHEA:67172 go.json http://purl.obolibrary.org/obo/GO_0106371 GO:0072521 biolink:BiologicalProcess purine-containing compound metabolic process The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. go.json purine and derivative metabolic process|purine-containing compound metabolism http://purl.obolibrary.org/obo/GO_0072521 GO:0106370 biolink:MolecularActivity protein-L-histidine N-pros-methyltransferase activity Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. RHEA:67076 go.json http://purl.obolibrary.org/obo/GO_0106370 GO:0072520 biolink:BiologicalProcess seminiferous tubule development The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. go.json http://purl.obolibrary.org/obo/GO_0072520 GO:0106375 biolink:MolecularActivity deoxynucleoside triphosphate hydrolase activity Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate. RHEA:46148 go.json http://purl.obolibrary.org/obo/GO_0106375 GO:0047595 biolink:MolecularActivity 6-hydroxynicotinate reductase activity Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin. EC:1.3.7.1|MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN|RHEA:17225 go.json 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity|6-hydroxynicotinic reductase activity|6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity|6-oxotetrahydro-nicotinate dehydrogenase activity|6-oxotetrahydronicotinate dehydrogenase activity|HNA reductase activity http://purl.obolibrary.org/obo/GO_0047595 GO:0072551 biolink:MolecularActivity diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0072551 GO:0047594 biolink:MolecularActivity 6-beta-hydroxyhyoscyamine epoxidase activity Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H2O + H+ + scopolamine + succinate. EC:1.14.20.13|KEGG_REACTION:R03737|MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN|RHEA:12797 go.json (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)|6beta-hydroxyhyoscyamine epoxidase activity|hydroxyhyoscyamine dioxygenase activity http://purl.obolibrary.org/obo/GO_0047594 GO:0072550 biolink:MolecularActivity triferuloylspermidine meta-hydroxylase activity Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O. MetaCyc:RXN-11262 go.json triferuloyl spermidine meta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0072550 GO:0047593 biolink:MolecularActivity 6-acetylglucose deacetylase activity Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate + H+. EC:3.1.1.33|KEGG_REACTION:R00327|MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN|RHEA:18485 go.json 6-O-acetylglucose deacetylase activity|6-acetyl-D-glucose acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0047593 GO:0106373 biolink:MolecularActivity 3-deoxyglucosone dehydrogenase activity Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH. RHEA:67244 go.json http://purl.obolibrary.org/obo/GO_0106373 GO:0047592 biolink:MolecularActivity 5-pyridoxate dioxygenase activity Catalysis of the reaction: 5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP+. EC:1.14.13.241|KEGG_REACTION:R04570|MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN|RHEA:11152 go.json 5-pyridoxate oxidase activity http://purl.obolibrary.org/obo/GO_0047592 GO:0106372 biolink:MolecularActivity primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC. RHEA:67176 go.json http://purl.obolibrary.org/obo/GO_0106372 GO:0047591 biolink:MolecularActivity 5-hydroxypentanoate CoA-transferase activity Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate. EC:2.8.3.14|KEGG_REACTION:R04057|MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN|RHEA:23496 go.json 5-hydroxyvalerate CoA-transferase activity|5-hydroxyvalerate coenzyme A transferase activity|acetyl-CoA:5-hydroxypentanoate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0047591 GO:0106379 biolink:MolecularActivity 8-oxo-(d)RTP hydrolase activity Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+. Reactome:R-HSA-9731228 go.json http://purl.obolibrary.org/obo/GO_0106379 GO:0106378 biolink:MolecularActivity 2-hydroxy-dATP hydrolase activity Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate. RHEA:31583|Reactome:R-HSA-2395818 go.json http://purl.obolibrary.org/obo/GO_0106378 GO:0047590 biolink:MolecularActivity 5-dehydro-2-deoxygluconokinase activity Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. EC:2.7.1.92|MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN|RHEA:13497 go.json 5-keto-2-deoxyglucono kinase (phosphorylating)|5-keto-2-deoxygluconokinase activity|ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity|DKH kinase activity http://purl.obolibrary.org/obo/GO_0047590 GO:0106377 biolink:MolecularActivity 2-hydroxy-ATP hydrolase activity Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate. RHEA:67392|Reactome:R-HSA-2395872 go.json http://purl.obolibrary.org/obo/GO_0106377 GO:0106376 biolink:MolecularActivity 2-hydroxyphytanoyl-CoA lyase activity Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA. RHEA:25355 go.json http://purl.obolibrary.org/obo/GO_0106376 GO:0047599 biolink:MolecularActivity 8-oxocoformycin reductase activity Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + 2 H+ + NADPH. EC:1.1.1.235|KEGG_REACTION:R03667|MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN|RHEA:23168 go.json 8-ketodeoxycoformycin reductase activity|coformycin:NADP+ 8-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047599 GO:0047598 biolink:MolecularActivity 7-dehydrocholesterol reductase activity Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. EC:1.3.1.21|MetaCyc:RXN66-323|RHEA:23984|Reactome:R-HSA-196402|Reactome:R-HSA-6807055 go.json 7-DHC reductase activity|cholesterol:NADP+ delta7-oxidoreductase activity|sterol Delta(7)-reductase activity|sterol delta7-reductase activity http://purl.obolibrary.org/obo/GO_0047598 GO:0047597 biolink:MolecularActivity 6-oxocineole dehydrogenase activity Catalysis of the reaction: 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+. EC:1.14.13.51|KEGG_REACTION:R02995|MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN|RHEA:24324 go.json 6-oxocineole oxygenase activity|6-oxocineole,NADPH:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047597 GO:0047596 biolink:MolecularActivity 6-methylsalicylate decarboxylase activity Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2. EC:4.1.1.52|KEGG_REACTION:R03567|MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN|RHEA:23112 go.json 6-MSA decarboxylase activity|6-methylsalicylate carboxy-lyase (3-cresol-forming)|6-methylsalicylate carboxy-lyase activity|6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity http://purl.obolibrary.org/obo/GO_0047596 GO:0072559 biolink:CellularComponent NLRP3 inflammasome complex An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. go.json NALP3 inflammasome complex http://purl.obolibrary.org/obo/GO_0072559 GO:0072558 biolink:CellularComponent NLRP1 inflammasome complex An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. go.json NALP1 inflammasome complex http://purl.obolibrary.org/obo/GO_0072558 GO:0072557 biolink:CellularComponent IPAF inflammasome complex An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri. go.json http://purl.obolibrary.org/obo/GO_0072557 GO:0072556 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072556 GO:0072555 biolink:MolecularActivity 17-beta-ketosteroid reductase activity Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+. go.json 17-beta-ketosteroid reductase (NADPH) activity|7beta-ketosteroid reductase activity http://purl.obolibrary.org/obo/GO_0072555 GO:0106381 biolink:BiologicalProcess purine deoxyribonucleotide salvage Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0106381 GO:0072554 biolink:BiologicalProcess blood vessel lumenization The process in which a developing blood vessel forms an endothelial lumen through which blood will flow. go.json http://purl.obolibrary.org/obo/GO_0072554 GO:0072553 biolink:BiologicalProcess terminal button organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. go.json bouton organization|presynaptic bouton organization|synaptic bouton organization|terminal bouton organization|terminal button organisation http://purl.obolibrary.org/obo/GO_0072553 GO:0106380 biolink:BiologicalProcess purine ribonucleotide salvage Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0106380 GO:0072552 biolink:MolecularActivity monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0072552 GO:0106386 biolink:MolecularActivity (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH. EC:1.1.1.n12|RHEA:32711 go.json http://purl.obolibrary.org/obo/GO_0106386 GO:0072540 biolink:BiologicalProcess T-helper 17 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. go.json T-helper 17 cell fate commitment|Th17 cell lineage commitment|Th17 fate commitment http://purl.obolibrary.org/obo/GO_0072540 GO:0106385 biolink:BiologicalProcess dIMP salvage Any process which produces a dIMP from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0106385 GO:0106384 biolink:BiologicalProcess dGMP salvage Any process which produces a dGMP from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0106384 GO:0106383 biolink:BiologicalProcess dAMP salvage Any process which produces a dAMP from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0106383 GO:0106389 biolink:MolecularActivity ecdysteroid 22-kinase activity Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+. MetaCyc:RXN-14755|RHEA:67972 go.json EcKinase http://purl.obolibrary.org/obo/GO_0106389 GO:0106388 biolink:MolecularActivity 18S rRNA aminocarboxypropyltransferase activity Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine. RHEA:63296 go.json http://purl.obolibrary.org/obo/GO_0106388 GO:0106387 biolink:BiologicalProcess 'de novo' GMP biosynthetic process The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate. go.json 'de novo' guanosine 5'-monophosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0106387 GO:0072549 biolink:MolecularActivity monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0072549 GO:0072548 biolink:MolecularActivity dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0072548 GO:0072547 biolink:MolecularActivity tricoumaroylspermidine meta-hydroxylase activity Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O. MetaCyc:RXN-11260 go.json tricoumaroyl spermidine meta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0072547 GO:0072546 biolink:CellularComponent EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. go.json ER membrane protein complex|endoplasmic reticulum membrane protein complex http://purl.obolibrary.org/obo/GO_0072546 GO:0072545 biolink:MolecularActivity tyrosine binding Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid. go.json Tyr binding http://purl.obolibrary.org/obo/GO_0072545 GO:0072544 biolink:MolecularActivity L-DOPA binding Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid. go.json http://purl.obolibrary.org/obo/GO_0072544 GO:0106393 biolink:BiologicalProcess regulation of palmitic acid catabolic process Any process that modulates the frequency, rate or extent of a palmitic acid catabolic process. go.json http://purl.obolibrary.org/obo/GO_0106393 GO:0106392 biolink:CellularComponent bI3 intron splicing complex Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing. Intact:EBI-16426213 go.json http://purl.obolibrary.org/obo/GO_0106392 GO:0072543 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072543 GO:0106391 biolink:CellularComponent bI4 intron splicing complex A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing. Intact:EBI-16420264 go.json http://purl.obolibrary.org/obo/GO_0106391 GO:0072542 biolink:MolecularActivity protein phosphatase activator activity Binds to and increases the activity of a protein phosphatase. go.json protein phosphatase 2 activator activity|protein phosphatase type 1 activator activity|protein phosphatase type 2A activator activity http://purl.obolibrary.org/obo/GO_0072542 GO:0072541 biolink:MolecularActivity peroxynitrite reductase activity Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O. go.json peroxynitritase activity http://purl.obolibrary.org/obo/GO_0072541 GO:0047702 biolink:MolecularActivity beta-lysine 5,6-aminomutase activity Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate. EC:5.4.3.3|KEGG_REACTION:R03275|MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN|RHEA:21736 go.json (3S)-3,6-diaminohexanoate 5,6-aminomutase activity|L-beta-lysine 5,6-aminomutase activity|b-lysine 5,6-aminomutase activity|beta-lysine mutase activity http://purl.obolibrary.org/obo/GO_0047702 GO:0047701 biolink:MolecularActivity beta-L-arabinosidase activity Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol. EC:3.2.1.88|MetaCyc:BETA-L-ARABINOSIDASE-RXN go.json b-L-arabinosidase activity|beta-L-arabinoside arabinohydrolase activity|vicianosidase activity http://purl.obolibrary.org/obo/GO_0047701 GO:0047700 biolink:MolecularActivity beta-glucoside kinase activity Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose. EC:2.7.1.85|MetaCyc:BETA-GLUCOSIDE-KINASE-RXN|RHEA:21944 go.json ATP:cellobiose 6-phosphotransferase activity|b-glucoside kinase activity|beta-D-glucoside kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0047700 GO:0047709 biolink:MolecularActivity bis(2-ethylhexyl)phthalate esterase activity Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H+. EC:3.1.1.60|KEGG_REACTION:R04202|MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN|RHEA:15529 go.json DEHP esterase activity|bis(2-ethylhexyl)phthalate acylhydrolase activity http://purl.obolibrary.org/obo/GO_0047709 GO:0047708 biolink:MolecularActivity biotinidase activity Catalysis of the reaction: biotin amide + H2O = biotin + NH3. EC:3.5.1.12|MetaCyc:BIOTINIDASE-RXN|RHEA:13081|Reactome:R-HSA-3076905|Reactome:R-HSA-3325540|Reactome:R-HSA-4167509|Reactome:R-HSA-4225086 go.json amidohydrolase biotinidase activity|biotin-amide amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047708 GO:0047707 biolink:MolecularActivity biotin-CoA ligase activity Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA. EC:6.2.1.11|MetaCyc:BIOTIN--COA-LIGASE-RXN|RHEA:19681 go.json biotin CoA synthetase activity|biotin:CoA ligase (AMP-forming)|biotinyl coenzyme A synthetase activity|biotinyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0047707 GO:0047706 biolink:MolecularActivity biochanin-A reductase activity Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH. EC:1.3.1.46|KEGG_REACTION:R02954|MetaCyc:BIOCHANIN-A-REDUCTASE-RXN|RHEA:12817 go.json dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047706 GO:0047705 biolink:MolecularActivity bilirubin oxidase activity Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O. EC:1.3.3.5|KEGG_REACTION:R02394|MetaCyc:BILIRUBIN-OXIDASE-RXN|RHEA:20980 go.json bilirubin oxidase M-1|bilirubin:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047705 GO:0047704 biolink:MolecularActivity bile-salt sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. EC:2.8.2.14|MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN|RHEA:14013 go.json 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity|BAST I activity|bile acid sulfotransferase I activity|bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity|bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity|bile-salt sulphotransferase activity|glycolithocholate sulfotransferase activity http://purl.obolibrary.org/obo/GO_0047704 goslim_chembl GO:0047703 biolink:MolecularActivity beta-nitroacrylate reductase activity Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH. EC:1.3.1.16|KEGG_REACTION:R03900|MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN|RHEA:23892 go.json 3-nitropropanoate:NADP+ oxidoreductase activity|b-nitroacrylate reductase activity http://purl.obolibrary.org/obo/GO_0047703 GO:0047713 biolink:MolecularActivity galactitol 2-dehydrogenase activity Catalysis of the reaction: galactitol + NAD+ = D-tagatose + H+ + NADH. EC:1.1.1.16|KEGG_REACTION:R02928|MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN|RHEA:20685 go.json http://purl.obolibrary.org/obo/GO_0047713 GO:0047712 biolink:MolecularActivity Cypridina-luciferin 2-monooxygenase activity Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light. EC:1.13.12.6|MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN|RHEA:22760 go.json Cypridina luciferase activity|Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)|Cypridina-type luciferase activity|luciferase (Cypridina luciferin)|luciferase activity http://purl.obolibrary.org/obo/GO_0047712 GO:0047711 biolink:MolecularActivity blasticidin-S deaminase activity Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3. EC:3.5.4.23|MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN|RHEA:10148 go.json blasticidin-S aminohydrolase activity http://purl.obolibrary.org/obo/GO_0047711 GO:0047710 biolink:MolecularActivity bis(5'-adenosyl)-triphosphatase activity Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+. EC:3.6.1.29|KEGG_REACTION:R00187|MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN|RHEA:13893 go.json 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity|AP(3)A hydrolase activity|AP(3)Aase activity|AP3A hydrolase activity|AP3Aase activity|P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity|diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity|diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity|diadenosine 5,5-P1,P3-triphosphatase activity|dinucleosidetriphosphatase activity http://purl.obolibrary.org/obo/GO_0047710 GO:0047719 biolink:MolecularActivity indole 2,3-dioxygenase activity Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde. EC:1.13.11.17|KEGG_REACTION:R02338|MetaCyc:INDOLE-23-DIOXYGENASE-RXN|RHEA:11212 go.json IDO|indole oxidase activity|indole-oxygen 2,3-oxidoreductase (decyclizing)|indole:O2 oxidoreductase activity|indole:oxygen 2,3-oxidoreductase (decyclizing) http://purl.obolibrary.org/obo/GO_0047719 GO:0047718 biolink:MolecularActivity indanol dehydrogenase activity Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. EC:1.1.1.112|MetaCyc:INDANOL-DEHYDROGENASE-RXN go.json indan-1-ol:NAD(P)+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047718 GO:0047717 biolink:MolecularActivity imidazoleacetate 4-monooxygenase activity Catalysis of the reaction: H+ + imidazol-4-ylacetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD+. EC:1.14.13.5|KEGG_REACTION:R04066|MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN|RHEA:19425 go.json 4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)|imidazoleacetate hydroxylase activity|imidazoleacetic hydroxylase activity|imidazoleacetic monooxygenase activity http://purl.obolibrary.org/obo/GO_0047717 GO:0047716 biolink:MolecularActivity imidazole N-acetyltransferase activity Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA. EC:2.3.1.2|KEGG_REACTION:R03621|MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN|RHEA:15813 go.json acetyl-CoA:imidazole N-acetyltransferase activity|imidazole acetylase activity|imidazole acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047716 GO:0047715 biolink:MolecularActivity hypotaurocyamine kinase activity Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H+. EC:2.7.3.6|KEGG_REACTION:R03939|MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN|RHEA:24008 go.json ATP:hypotaurocyamine N-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047715 GO:0047714 biolink:MolecularActivity galactolipase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. EC:3.1.1.26|MetaCyc:GALACTOLIPASE-RXN|RHEA:13189 go.json 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity|galactolipid acylhydrolase activity|galactolipid lipase activity|polygalactolipase activity http://purl.obolibrary.org/obo/GO_0047714 GO:0047724 biolink:MolecularActivity inosine nucleosidase activity Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine. EC:3.2.2.2|MetaCyc:INOSINE-NUCLEOSIDASE-RXN|RHEA:16657 go.json inosinase activity|inosine ribohydrolase activity|inosine-guanosine nucleosidase activity http://purl.obolibrary.org/obo/GO_0047724 GO:0047723 biolink:MolecularActivity inosinate nucleosidase activity Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine. EC:3.2.2.12|KEGG_REACTION:R01128|MetaCyc:INOSINATE-NUCLEOSIDASE-RXN|RHEA:20469 go.json 5'-inosinate phosphoribohydrolase activity http://purl.obolibrary.org/obo/GO_0047723 GO:0047722 biolink:MolecularActivity indolelactate dehydrogenase (NADH) activity Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD+ = 3-(indol-3-yl)pyruvate + H+ + NADH. EC:1.1.1.110|KEGG_REACTION:R01971|MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN|RHEA:20133 go.json (indol-3-yl)lactate:NAD+ oxidoreductase activity|indole-3-lactate dehydrogenase activity|indolelactate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047722 GO:0047721 biolink:MolecularActivity indoleacetate-lysine synthetase activity Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H+ + phosphate. EC:6.3.2.20|KEGG_REACTION:R03095|MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN|RHEA:14857 go.json (indol-3-yl)acetate:L-lysine ligase (ADP-forming)|IAA-lysine synthetase activity|N-(indole-3-acetyl)-L-lysine synthetase activity|indoleacetate-lysine ligase activity|indoleacetate:L-lysine ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0047721 GO:0047720 biolink:MolecularActivity indoleacetaldoxime dehydratase activity Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O. EC:4.99.1.6|KEGG_REACTION:R04093|MetaCyc:RXN-19838|RHEA:23156 go.json (indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]|(indol-3-yl)acetaldehyde-oxime hydro-lyase activity|3-indoleacetaldoxime hydro-lyase activity|indole-3-acetaldehyde-oxime hydro-lyase activity|indole-3-acetaldoxime hydro-lyase activity|indoleacetaldoxime hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047720 GO:0047729 biolink:MolecularActivity carnitine decarboxylase activity Catalysis of the reaction: carnitine + H+ = 2-methylcholine + CO2. EC:4.1.1.42|KEGG_REACTION:R02398|MetaCyc:CARNITINE-DECARBOXYLASE-RXN|RHEA:21576 go.json carnitine carboxy-lyase (2-methylcholine-forming)|carnitine carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047729 GO:0047728 biolink:MolecularActivity carnitine 3-dehydrogenase activity Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH. EC:1.1.1.108|KEGG_REACTION:R02395|MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN|RHEA:19265 go.json carnitine:NAD+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047728 GO:0047727 biolink:MolecularActivity isobutyryl-CoA mutase activity Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA. EC:5.4.99.13|KEGG_REACTION:R01181|MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN|RHEA:13141 go.json 2-methylpropanoyl-CoA CoA-carbonylmutase activity|butyryl-CoA:isobutyryl-CoA mutase activity|isobutyryl coenzyme A mutase activity http://purl.obolibrary.org/obo/GO_0047727 GO:0047726 biolink:MolecularActivity iron-cytochrome-c reductase activity Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+. EC:1.9.98.1|MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN|RHEA:15617 go.json ferrocytochrome-c:Fe3+ oxidoreductase activity|iron-cytochrome c reductase activity http://purl.obolibrary.org/obo/GO_0047726 GO:0047725 biolink:MolecularActivity inulosucrase activity Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1). EC:2.4.1.9|MetaCyc:RXN-15518|RHEA:15745 go.json sucrose 1-fructosyl transferase activity|sucrose 1-fructosyltransferase activity|sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity http://purl.obolibrary.org/obo/GO_0047725 GO:0047735 biolink:MolecularActivity cellobiose dehydrogenase (acceptor) activity Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor. EC:1.1.99.18|MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN|RHEA:23484 go.json CBOR activity|CDH activity|cellobiose dehydrogenase (quinone) activity|cellobiose dehydrogenase activity|cellobiose oxidase activity|cellobiose oxidoreductase activity|cellobiose-quinone oxidoreductase activity|cellobiose:(acceptor) 1-oxidoreductase activity|cellobiose:acceptor 1-oxidoreductase activity|cellobiose:oxygen 1-oxidoreductase activity|phanerochaete chrysosporium cellobiose oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047735 GO:0047734 biolink:MolecularActivity CDP-glycerol diphosphatase activity Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+. EC:3.6.1.16|KEGG_REACTION:R00855|MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN|RHEA:21692 go.json CDP-glycerol phosphoglycerohydrolase activity|CDP-glycerol pyrophosphatase activity|CDPglycerol diphosphatase activity|CDPglycerol phosphoglycerohydrolase activity|CDPglycerol pyrophosphatase activity|cytidine diphosphoglycerol pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0047734 GO:0047733 biolink:MolecularActivity CDP-glucose 4,6-dehydratase activity Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O. EC:4.2.1.45|KEGG_REACTION:R02426|MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN|RHEA:17153 go.json CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)|CDP-glucose 4,6-hydro-lyase activity|CDPglucose 4,6-dehydratase activity|CDPglucose 4,6-hydro-lyase activity|cytidine diphosphoglucose oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047733 GO:0047732 biolink:MolecularActivity CDP-abequose epimerase activity Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose. EC:5.1.3.10|KEGG_REACTION:R04266|MetaCyc:RXN-9160|RHEA:21656 go.json CDP-3,6-dideoxy-D-glucose 2-epimerase activity|CDP-D-abequose 2-epimerase activity|CDP-paratose 2-epimerase activity|CDP-paratose epimerase activity|CDP-tyvelose 2-epimerase activity|cytidine diphosphate paratose-2-epimerase activity|cytidine diphosphoabequose epimerase activity|cytidine diphosphodideoxyglucose epimerase activity|cytidine diphosphoparatose epimerase activity http://purl.obolibrary.org/obo/GO_0047732 GO:0047731 biolink:MolecularActivity catechol oxidase (dimerizing) activity Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O. EC:1.1.3.14|MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN|RHEA:12809 go.json catechol:oxygen oxidoreductase (dimerizing) http://purl.obolibrary.org/obo/GO_0047731 GO:0047730 biolink:MolecularActivity carnosine synthase activity Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. EC:6.3.2.11|MetaCyc:CARNOSINE-SYNTHASE-RXN|RHEA:19297|Reactome:R-HSA-6786245 go.json L-histidine:beta-alanine ligase (AMP-forming)|carnosine synthetase activity|carnosine-anserine synthetase activity|carnosine-homocarnosine synthetase activity|homocarnosine-carnosine synthetase activity http://purl.obolibrary.org/obo/GO_0047730 GO:0047739 biolink:MolecularActivity cephalosporin-C deacetylase activity Catalysis of the reaction: cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+. EC:3.1.1.41|KEGG_REACTION:R03062|MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN|RHEA:22596 go.json cephalosporin C acetyl-esterase activity|cephalosporin C acetyl-hydrolase activity|cephalosporin C acetylase activity|cephalosporin C acetylesterase activity|cephalosporin C deacetylase activity|cephalosporin acetylesterase activity|cephalosporin-C acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0047739 GO:0047738 biolink:MolecularActivity cellobiose phosphorylase activity Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose. EC:2.4.1.20|MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN|RHEA:19493 go.json cellobiose:phosphate alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047738 GO:0047737 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047737 GO:0047736 biolink:MolecularActivity cellobiose epimerase activity Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose. EC:5.1.3.11|MetaCyc:CELLOBIOSE-EPIMERASE-RXN|RHEA:23384 go.json cellobiose 2-epimerase activity http://purl.obolibrary.org/obo/GO_0047736 GO:0047746 biolink:MolecularActivity chlorophyllase activity Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide. EC:3.1.1.14|MetaCyc:CHLOROPHYLLASE-RXN go.json chlorophyll chlorophyllidohydrolase activity http://purl.obolibrary.org/obo/GO_0047746 GO:0047745 biolink:MolecularActivity chlorogenate hydrolase activity Catalysis of the reaction: chlorogenate + H2O = (-)-quinate + cis-caffeate + H+. EC:3.1.1.42|KEGG_REACTION:R02997|MetaCyc:CHLOROGENATE-HYDROLASE-RXN|RHEA:20689 go.json chlorogenase activity|chlorogenic acid esterase activity http://purl.obolibrary.org/obo/GO_0047745 GO:0047744 biolink:MolecularActivity chloridazon-catechol dioxygenase activity Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H+. EC:1.13.11.36|KEGG_REACTION:R04602|MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN|RHEA:20449 go.json 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing) http://purl.obolibrary.org/obo/GO_0047744 GO:0047743 biolink:MolecularActivity chlordecone reductase activity Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH. EC:1.1.1.225|KEGG_REACTION:R03716|MetaCyc:CHLORDECONE-REDUCTASE-RXN|RHEA:14401 go.json CDR activity|chlordecone-alcohol:NADP+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047743 GO:0047742 biolink:MolecularActivity chenodeoxycholoyltaurine hydrolase activity Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine. EC:3.5.1.74|MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN|RHEA:16309 go.json chenodeoxycholoyltaurine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047742 GO:0047741 biolink:MolecularActivity cetraxate benzylesterase activity Catalysis of the reaction: benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+. EC:3.1.1.70|KEGG_REACTION:R03612|MetaCyc:CETRAXATE-BENZYLESTERASE-RXN|RHEA:23460 go.json cetraxate-benzyl-ester benzylhydrolase activity http://purl.obolibrary.org/obo/GO_0047741 GO:0047740 biolink:MolecularActivity cephalosporin-C transaminase activity Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C. EC:2.6.1.74|KEGG_REACTION:R03063|MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN|RHEA:14553 go.json L-alanine:cephalosporin-C aminotransferase activity|cephalosporin C aminotransferase activity|cephalosporin-C:2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047740 GO:0047749 biolink:MolecularActivity cholestanetriol 26-monooxygenase activity Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. EC:1.14.15.15|MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN|RHEA:14373 go.json 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity|5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity|5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity|5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity|5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)|CYP27A|CYP27A1|cholestanetriol 26-hydroxylase activity|cholesterol 27-hydroxylase activity|cytochrome P450 27A1' activity|sterol 26-hydroxylase activity|sterol 27-hydroxylase activity http://purl.obolibrary.org/obo/GO_0047749 GO:0047748 biolink:MolecularActivity cholestanetetraol 26-dehydrogenase activity Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH. MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN|RHEA:34631 go.json 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity|5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity|TEHC-NAD oxidoreductase activity|cholestanetetrol 26-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047748 GO:0047747 biolink:MolecularActivity cholate-CoA ligase activity Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. EC:6.2.1.7|MetaCyc:CHOLATE--COA-LIGASE-RXN go.json 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity|BAL activity|THCA-CoA ligase activity|bile acid CoA ligase activity|bile acid coenzyme A ligase activity|cholate thiokinase activity|cholate:CoA ligase (AMP-forming)|cholic acid:CoA ligase activity|cholic thiokinase activity|choloyl coenzyme A synthetase activity|choloyl-CoA synthetase activity|cholyl-CoA synthetase activity|trihydroxycoprostanoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0047747 GO:0047757 biolink:MolecularActivity chondroitin-glucuronate 5-epimerase activity Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. EC:5.1.3.19|MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN|RHEA:21084|Reactome:R-HSA-2022052 go.json chondroitin D-glucuronosyl 5-epimerase activity|chondroitin-D-glucuronate 5-epimerase activity|dermatan-sulfate 5-epimerase activity|polyglucuronate 5-epimerase activity|urunosyl C-5 epimerase activity http://purl.obolibrary.org/obo/GO_0047757 GO:0047756 biolink:MolecularActivity chondroitin 4-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate. EC:2.8.2.5|MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN|RHEA:16101|Reactome:R-HSA-1971483 go.json 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity|chondroitin 4-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047756 GO:0047755 biolink:MolecularActivity isocitrate epimerase activity Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate. EC:5.1.2.6|KEGG_REACTION:R02318|MetaCyc:ISOCITRATE-EPIMERASE-RXN|RHEA:10820 go.json (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity http://purl.obolibrary.org/obo/GO_0047755 GO:0047754 biolink:MolecularActivity choline sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H+. EC:2.8.2.6|KEGG_REACTION:R01027|MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN|RHEA:21984 go.json 3'-phosphoadenylyl-sulfate:choline sulfotransferase activity|choline sulphokinase activity|choline sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047754 GO:0047753 biolink:MolecularActivity choline-sulfatase activity Catalysis of the reaction: choline sulfate + H2O = choline + H+ + sulfate. EC:3.1.6.6|KEGG_REACTION:R01028|MetaCyc:CHOLINE-SULFATASE-RXN|RHEA:20820 go.json choline-sulfate sulfohydrolase activity|choline-sulphatase activity http://purl.obolibrary.org/obo/GO_0047753 GO:0047752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047752 GO:0047751 biolink:MolecularActivity 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH. EC:1.3.1.22|EC:1.3.1.30|KEGG_REACTION:R02610|MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN|MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN|RHEA:54384 go.json 3-oxosteroid 5alpha-reductase activity|3-oxosteroid delta4-dehydrogenase|cholestenone 5-alpha-reductase activity|cholestenone 5a-reductase activity|cholestenone 5alpha-reductase activity|progesterone 5-alpha-reductase activity|steroid 5alpha-hydrogenase activity|steroid 5alpha-reductase|testosterone 5alpha-reductase|testosterone delta4-hydrogenase activity http://purl.obolibrary.org/obo/GO_0047751 GO:0047750 biolink:MolecularActivity cholestenol delta-isomerase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. EC:5.3.3.5|MetaCyc:RXN66-25|RHEA:15281 go.json cholestenol D-isomerase activity|delta7-cholestenol delta7-delta8-isomerase activity http://purl.obolibrary.org/obo/GO_0047750 GO:0072719 biolink:BiologicalProcess cellular response to cisplatin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072719 GO:0072718 biolink:BiologicalProcess response to cisplatin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072718 GO:0072717 biolink:BiologicalProcess cellular response to actinomycin D Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. go.json http://purl.obolibrary.org/obo/GO_0072717 GO:0072716 biolink:BiologicalProcess response to actinomycin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. go.json http://purl.obolibrary.org/obo/GO_0072716 GO:0047759 biolink:MolecularActivity butanal dehydrogenase activity Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+. EC:1.2.1.57|MetaCyc:BUTANAL-DEHYDROGENASE-RXN go.json butanal:NAD(P)+ oxidoreductase (CoA-acylating) http://purl.obolibrary.org/obo/GO_0047759 GO:0072715 biolink:BiologicalProcess cellular response to selenite ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0072715 GO:0047758 biolink:MolecularActivity ATP:2-methylpropanoate phosphotransferase activity Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H+. EC:2.7.2.14|KEGG_REACTION:R04002|MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN|RHEA:24156 go.json ATP:2-methylpropanoate 1-phosphotransferase activity|ATP:2-methylpropanoate kinase activity|ATP:branched-chain-fatty-acid 1-phosphotransferase activity|ATP:isobutyrate 1-phosphotransferase activity|branched-chain fatty acid kinase activity|branched-chain-fatty-acid kinase activity|isobutyrate kinase activity http://purl.obolibrary.org/obo/GO_0047758 GO:0072714 biolink:BiologicalProcess response to selenite ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0072714 GO:0072713 biolink:BiologicalProcess cellular response to thiabendazole Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus. go.json cellular response to TBZ http://purl.obolibrary.org/obo/GO_0072713 GO:0072712 biolink:BiologicalProcess response to thiabendazole Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus. go.json response to TBZ http://purl.obolibrary.org/obo/GO_0072712 GO:0072711 biolink:BiologicalProcess cellular response to hydroxyurea Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. go.json cellular response to HU http://purl.obolibrary.org/obo/GO_0072711 GO:0072710 biolink:BiologicalProcess response to hydroxyurea Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. go.json response to HU http://purl.obolibrary.org/obo/GO_0072710 GO:0047760 biolink:MolecularActivity butyrate-CoA ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. EC:6.2.1.2|MetaCyc:BUTYRATE--COA-LIGASE-RXN|RHEA:24336|Reactome:R-HSA-8875013 go.json L-(+)-3-hydroxybutyryl CoA ligase activity|acyl-activating enzyme activity|butanoate:CoA ligase (AMP-forming)|butyryl-CoA synthetase activity|butyryl-coenzyme A synthetase activity|fatty acid activating enzyme|fatty acid thiokinase (medium chain) activity|fatty acyl coenzyme A synthetase activity|medium chain acyl-CoA synthetase activity|short-chain acyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0047760 GO:0047768 biolink:MolecularActivity carboxy-cis,cis-muconate cyclase activity Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate. EC:5.5.1.5|KEGG_REACTION:R03308|MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN|RHEA:14977 go.json 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)|3-carboxy-cis,cis-muconate lactonizing enzyme activity|3-carboxymuconate cyclase activity http://purl.obolibrary.org/obo/GO_0047768 GO:0047767 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047767 GO:0047766 biolink:MolecularActivity carbamoyl-serine ammonia-lyase activity Catalysis of the reaction: O-carbamoyl-L-serine + H2O + H+ = CO2 + 2 NH4 + pyruvate. EC:4.3.1.13|KEGG_REACTION:R00213|MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN|RHEA:15445 go.json O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)|O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)|O-carbamoyl-L-serine deaminase activity|carbamoylserine deaminase activity http://purl.obolibrary.org/obo/GO_0047766 GO:0047765 biolink:MolecularActivity caldesmon-phosphatase activity Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate. EC:3.1.3.55|MetaCyc:CALDESMON-PHOSPHATASE-RXN go.json SMP-I|caldesmon-phosphate phosphohydrolase activity|smooth muscle caldesmon phosphatase activity http://purl.obolibrary.org/obo/GO_0047765 GO:0047764 biolink:MolecularActivity obsolete caldesmon kinase activity OBSOLETE. Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate. MetaCyc:2.7.11.17-RXN go.json True http://purl.obolibrary.org/obo/GO_0047764 GO:0047763 biolink:MolecularActivity caffeate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate. EC:2.1.1.68|MetaCyc:RXN-1104|RHEA:20225 go.json S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity|S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity|caffeate 3-O-methyltransferase activity|caffeate methyltransferase activity http://purl.obolibrary.org/obo/GO_0047763 GO:0047762 biolink:MolecularActivity caffeate 3,4-dioxygenase activity Catalysis of the reaction: trans-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H+. EC:1.13.11.22|KEGG_REACTION:R03365|MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN|RHEA:22216 go.json 3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing) http://purl.obolibrary.org/obo/GO_0047762 GO:0047761 biolink:MolecularActivity butyrate kinase activity Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H+. EC:2.7.2.7|KEGG_REACTION:R01688|MetaCyc:BUTYRATE-KINASE-RXN|RHEA:13585 go.json ATP:butanoate 1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047761 GO:0072709 biolink:BiologicalProcess cellular response to sorbitol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. go.json cellular response to glucitol http://purl.obolibrary.org/obo/GO_0072709 GO:0072708 biolink:BiologicalProcess response to sorbitol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. go.json response to glucitol http://purl.obolibrary.org/obo/GO_0072708 GO:0072707 biolink:BiologicalProcess cellular response to sodium dodecyl sulfate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. go.json cellular response to SDS http://purl.obolibrary.org/obo/GO_0072707 GO:0072706 biolink:BiologicalProcess response to sodium dodecyl sulfate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. go.json response to SDS http://purl.obolibrary.org/obo/GO_0072706 GO:0072705 biolink:BiologicalProcess cellular response to mercaptoethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus. go.json cellular response to 2-sulfanylethanol http://purl.obolibrary.org/obo/GO_0072705 GO:0072704 biolink:BiologicalProcess response to mercaptoethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus. go.json response to 2-sulfanylethanol http://purl.obolibrary.org/obo/GO_0072704 GO:0072703 biolink:BiologicalProcess cellular response to methyl methanesulfonate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. go.json cellular response to MMS http://purl.obolibrary.org/obo/GO_0072703 GO:0047769 biolink:MolecularActivity arogenate dehydratase activity Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. EC:4.2.1.91|MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN|RHEA:12536 go.json L-arogenate hydro-lyase (decarboxylating)|L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)|carboxycyclohexadienyl dehydratase activity http://purl.obolibrary.org/obo/GO_0047769 GO:0072702 biolink:BiologicalProcess response to methyl methanesulfonate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. go.json response to MMS http://purl.obolibrary.org/obo/GO_0072702 GO:0072701 biolink:BiologicalProcess cellular response to bismuth Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus. go.json cellular response to bismuth ion http://purl.obolibrary.org/obo/GO_0072701 GO:0072700 biolink:BiologicalProcess response to bismuth Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus. go.json response to bismuth ion http://purl.obolibrary.org/obo/GO_0072700 GO:0033129 biolink:BiologicalProcess obsolete positive regulation of histone phosphorylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. go.json True http://purl.obolibrary.org/obo/GO_0033129 GO:0033128 biolink:BiologicalProcess obsolete negative regulation of histone phosphorylation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. go.json True http://purl.obolibrary.org/obo/GO_0033128 GO:0008169 biolink:MolecularActivity C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0008169 GO:0008168 biolink:MolecularActivity methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule. EC:2.1.1.-|Reactome:R-HSA-212269|Reactome:R-HSA-379387|Reactome:R-HSA-379464|Reactome:R-HSA-6800149|Reactome:R-HSA-71286|Reactome:R-HSA-9710490 go.json methylase http://purl.obolibrary.org/obo/GO_0008168 goslim_chembl|goslim_drosophila|goslim_yeast GO:0008167 biolink:BiologicalProcess obsolete sigma virus replication OBSOLETE. (Was not defined before being made obsolete). go.json sigma virus replication True http://purl.obolibrary.org/obo/GO_0008167 GO:0008166 biolink:BiologicalProcess obsolete viral replication OBSOLETE. (Was not defined before being made obsolete). go.json viral replication True http://purl.obolibrary.org/obo/GO_0008166 GO:0008165 biolink:BiologicalProcess obsolete pyrethroid resistance OBSOLETE. (Was not defined before being made obsolete). go.json pyrethroid resistance True http://purl.obolibrary.org/obo/GO_0008165 GO:0008164 biolink:BiologicalProcess obsolete organophosphorus resistance OBSOLETE. (Was not defined before being made obsolete). go.json organophosphorus resistance True http://purl.obolibrary.org/obo/GO_0008164 GO:0008174 biolink:MolecularActivity mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0008174 GO:0008173 biolink:MolecularActivity RNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. Reactome:R-HSA-191784 go.json http://purl.obolibrary.org/obo/GO_0008173 GO:0008172 biolink:MolecularActivity S-methyltransferase activity Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. Reactome:R-HSA-209821 go.json http://purl.obolibrary.org/obo/GO_0008172 GO:0008171 biolink:MolecularActivity O-methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. Reactome:R-HSA-5578717|Reactome:R-HSA-5629203|Reactome:R-HSA-5629218|Reactome:R-HSA-5629237|Reactome:R-HSA-6790907 go.json http://purl.obolibrary.org/obo/GO_0008171 GO:0008170 biolink:MolecularActivity N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0008170 GO:0033127 biolink:BiologicalProcess obsolete regulation of histone phosphorylation OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. go.json True http://purl.obolibrary.org/obo/GO_0033127 GO:0033126 biolink:BiologicalProcess obsolete positive regulation of GTP catabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate. go.json positive regulation of GTP breakdown|positive regulation of GTP catabolism|positive regulation of GTP degradation True http://purl.obolibrary.org/obo/GO_0033126 GO:0033125 biolink:BiologicalProcess obsolete negative regulation of GTP catabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate. go.json negative regulation of GTP breakdown|negative regulation of GTP catabolism|negative regulation of GTP degradation True http://purl.obolibrary.org/obo/GO_0033125 GO:0033124 biolink:BiologicalProcess obsolete regulation of GTP catabolic process OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate. go.json regulation of GTP breakdown|regulation of GTP catabolism|regulation of GTP degradation True http://purl.obolibrary.org/obo/GO_0033124 GO:0033123 biolink:BiologicalProcess positive regulation of purine nucleotide catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. go.json positive regulation of purine nucleotide breakdown|positive regulation of purine nucleotide catabolism|positive regulation of purine nucleotide degradation http://purl.obolibrary.org/obo/GO_0033123 GO:0033122 biolink:BiologicalProcess negative regulation of purine nucleotide catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. go.json negative regulation of purine nucleotide breakdown|negative regulation of purine nucleotide catabolism|negative regulation of purine nucleotide degradation http://purl.obolibrary.org/obo/GO_0033122 GO:0033121 biolink:BiologicalProcess regulation of purine nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. go.json regulation of purine nucleotide breakdown|regulation of purine nucleotide catabolism|regulation of purine nucleotide degradation http://purl.obolibrary.org/obo/GO_0033121 GO:0033120 biolink:BiologicalProcess positive regulation of RNA splicing Any process that activates or increases the frequency, rate or extent of RNA splicing. go.json http://purl.obolibrary.org/obo/GO_0033120 GO:0033119 biolink:BiologicalProcess negative regulation of RNA splicing Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. go.json http://purl.obolibrary.org/obo/GO_0033119 GO:0033118 biolink:CellularComponent esterosome membrane The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes. go.json http://purl.obolibrary.org/obo/GO_0033118 GO:0033117 biolink:CellularComponent esterosome A vesicle filled with crystalline protein that shows sequence similarities with various esterases. go.json http://purl.obolibrary.org/obo/GO_0033117 GO:0008179 biolink:MolecularActivity adenylate cyclase binding Binding to an adenylate cyclase. Reactome:R-HSA-170672 go.json adenylyl cyclase binding http://purl.obolibrary.org/obo/GO_0008179 GO:0008178 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008178 GO:0008177 biolink:MolecularActivity succinate dehydrogenase (ubiquinone) activity Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. EC:1.3.5.1|KEGG_REACTION:R02164|MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN|RHEA:13713|Reactome:R-HSA-163213|Reactome:R-HSA-70994 go.json succinate:ubiquinone oxidoreductase activity|succinic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008177 GO:0008176 biolink:MolecularActivity tRNA (guanine(46)-N7)-methyltransferase activity Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.33|MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN|RHEA:42708|Reactome:R-HSA-6782286 go.json 7-methylguanine transfer ribonucleate methylase activity|N7-methylguanine methylase activity|tRNA (guanine(46)-N7-)-methyltransferase activity|tRNA (guanine-N7-)-methyltransferase activity|tRNA (guanosine(46)-N(7))-methyltransferase activity|tRNA (guanosine(46)-N7)-methyltransferase activity|tRNA (guanosine(46)-N7-)-methyltransferase activity|tRNA guanine 7-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008176 GO:0008175 biolink:MolecularActivity tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. Reactome:R-HSA-6782879|Reactome:R-HSA-6782881|Reactome:R-HSA-6782890|Reactome:R-HSA-6783473|Reactome:R-HSA-6786500|Reactome:R-HSA-6786567 go.json http://purl.obolibrary.org/obo/GO_0008175 GO:0008185 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008185 GO:0008184 biolink:MolecularActivity glycogen phosphorylase activity Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. MetaCyc:GLYCOPHOSPHORYL-RXN|Reactome:R-HSA-453339|Reactome:R-HSA-453358|Reactome:R-HSA-71515|Reactome:R-HSA-71590 go.json http://purl.obolibrary.org/obo/GO_0008184 GO:0008183 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008183 GO:0008182 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008182 GO:0008181 biolink:MolecularActivity obsolete tumor suppressor OBSOLETE. (Was not defined before being made obsolete). go.json tumor suppressor True http://purl.obolibrary.org/obo/GO_0008181 GO:0008180 biolink:CellularComponent COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. go.json COP9 complex|CSN|signalosome http://purl.obolibrary.org/obo/GO_0008180 GO:0033116 biolink:CellularComponent endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. go.json ER-Golgi intermediate compartment membrane http://purl.obolibrary.org/obo/GO_0033116 GO:0033115 biolink:CellularComponent cyanelle thylakoid membrane The lipid bilayer membrane of any thylakoid within a cyanelle. go.json http://purl.obolibrary.org/obo/GO_0033115 GO:0033114 biolink:CellularComponent cyanelle thylakoid lumen The volume enclosed by a cyanelle thylakoid membrane. go.json http://purl.obolibrary.org/obo/GO_0033114 GO:0033113 biolink:CellularComponent cyanelle membrane Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope. go.json http://purl.obolibrary.org/obo/GO_0033113 GO:0033112 biolink:CellularComponent cyanelle envelope The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0033112 GO:0033111 biolink:CellularComponent attachment organelle membrane The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane. go.json http://purl.obolibrary.org/obo/GO_0033111 GO:0033110 biolink:CellularComponent Cvt vesicle membrane Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway. go.json cytoplasm to vacuole targeting vesicle membrane|cytoplasm-to-vacuole targeting vesicle membrane http://purl.obolibrary.org/obo/GO_0033110 GO:0033109 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033109 GO:0033108 biolink:BiologicalProcess mitochondrial respiratory chain complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. go.json http://purl.obolibrary.org/obo/GO_0033108 GO:0033107 biolink:CellularComponent Cvt vesicle A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p). go.json cytoplasm to vacuole targeting vesicle|cytoplasm-to-vacuole targeting vesicle http://purl.obolibrary.org/obo/GO_0033107 GO:0033106 biolink:CellularComponent cis-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network. go.json Golgi cis face membrane|cis Golgi network membrane http://purl.obolibrary.org/obo/GO_0033106 GO:0008149 biolink:MolecularActivity obsolete para-aminobenzoic acid (PABA) synthase OBSOLETE. (Was not defined before being made obsolete). go.json para-aminobenzoic acid (PABA) synthase True http://purl.obolibrary.org/obo/GO_0008149 GO:0008148 biolink:MolecularActivity obsolete negative transcription elongation factor activity OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. go.json negative transcription elongation factor activity True http://purl.obolibrary.org/obo/GO_0008148 GO:0008147 biolink:MolecularActivity structural constituent of bone The action of a molecule that contributes to the structural integrity of bone. go.json http://purl.obolibrary.org/obo/GO_0008147 GO:0008146 biolink:MolecularActivity sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. EC:2.8.2.-|Reactome:R-HSA-176588|Reactome:R-HSA-176604|Reactome:R-HSA-176669|Reactome:R-HSA-2022061|Reactome:R-HSA-9753277 go.json sulphotransferase activity http://purl.obolibrary.org/obo/GO_0008146 goslim_chembl GO:0008145 biolink:MolecularActivity phenylalkylamine binding Binding to phenylalkylamine or one of its derivatives. go.json http://purl.obolibrary.org/obo/GO_0008145 GO:0008144 biolink:MolecularActivity obsolete drug binding OBSOLETE. Binding to a drug, a naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism;typically used in the diagnosis, prevention, or treatment of disease. go.json True http://purl.obolibrary.org/obo/GO_0008144 GO:0008143 biolink:MolecularActivity poly(A) binding Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. go.json poly(A) binding, within an RNA molecule|poly(rA) binding|poly-A binding|polyadenylate binding http://purl.obolibrary.org/obo/GO_0008143 GO:0008142 biolink:MolecularActivity oxysterol binding Binding to oxysterol, an oxidized form of cholesterol. go.json http://purl.obolibrary.org/obo/GO_0008142 GO:0008152 biolink:BiologicalProcess metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. Wikipedia:Metabolism go.json metabolic process resulting in cell growth|metabolism|metabolism resulting in cell growth|multicellular organism metabolic process|single-organism metabolic process http://purl.obolibrary.org/obo/GO_0008152 gocheck_do_not_manually_annotate|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant GO:0008151 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008151 GO:0008150 biolink:BiologicalProcess biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. Wikipedia:Biological_process go.json biological process|physiological process|single organism process|single-organism process http://purl.obolibrary.org/obo/GO_0008150 goslim_candida|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant|goslim_pombe|goslim_yeast GO:0033105 biolink:CellularComponent chlorosome envelope The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome. go.json chlorosome membrane http://purl.obolibrary.org/obo/GO_0033105 GO:0033104 biolink:CellularComponent type VI protein secretion system complex A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. go.json T6SS complex http://purl.obolibrary.org/obo/GO_0033104 GO:0033103 biolink:BiologicalProcess protein secretion by the type VI secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence. go.json protein secretion by the T6SS|protein secretion by the type VI protein secretion system|type VI protein secretion system http://purl.obolibrary.org/obo/GO_0033103 GO:0033102 biolink:CellularComponent acidocalcisome membrane The lipid bilayer surrounding an acidocalcisome. go.json http://purl.obolibrary.org/obo/GO_0033102 GO:0033101 biolink:CellularComponent cellular bud membrane The portion of the plasma membrane surrounding a cellular bud. go.json cellular bud plasma membrane http://purl.obolibrary.org/obo/GO_0033101 GO:0033100 biolink:CellularComponent NuA3 histone acetyltransferase complex A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p. go.json http://purl.obolibrary.org/obo/GO_0033100 GO:0008159 biolink:MolecularActivity obsolete positive transcription elongation factor activity OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. go.json positive transcription elongation factor activity True http://purl.obolibrary.org/obo/GO_0008159 GO:0008158 biolink:MolecularActivity hedgehog receptor activity Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. go.json patched activity http://purl.obolibrary.org/obo/GO_0008158 GO:0008157 biolink:MolecularActivity protein phosphatase 1 binding Binding to a protein phosphatase 1. go.json http://purl.obolibrary.org/obo/GO_0008157 GO:0008156 biolink:BiologicalProcess negative regulation of DNA replication Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. go.json DNA replication inhibitor|down regulation of DNA replication|down-regulation of DNA replication|downregulation of DNA replication|inhibition of DNA replication http://purl.obolibrary.org/obo/GO_0008156 GO:0008155 biolink:BiologicalProcess obsolete larval behavior (sensu Drosophila) OBSOLETE. (Was not defined before being made obsolete). go.json larval behavior (sensu Drosophila) True http://purl.obolibrary.org/obo/GO_0008155 GO:0008154 biolink:BiologicalProcess actin polymerization or depolymerization Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. go.json http://purl.obolibrary.org/obo/GO_0008154 GO:0008153 biolink:BiologicalProcess para-aminobenzoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. go.json 4-aminobenzoic acid biosynthesis|4-aminobenzoic acid biosynthetic process|PABA biosynthesis|PABA biosynthetic process|p-aminobenzoic acid biosynthesis|p-aminobenzoic acid biosynthetic process|para-aminobenzoic acid anabolism|para-aminobenzoic acid biosynthesis|para-aminobenzoic acid formation|para-aminobenzoic acid synthesis|vitamin Bx biosynthesis|vitamin Bx biosynthetic process http://purl.obolibrary.org/obo/GO_0008153 GO:0008163 biolink:BiologicalProcess obsolete DDT resistance OBSOLETE. (Was not defined before being made obsolete). go.json DDT resistance True http://purl.obolibrary.org/obo/GO_0008163 GO:0008162 biolink:BiologicalProcess obsolete cyclodiene resistance OBSOLETE. (Was not defined before being made obsolete). go.json cyclodiene resistance True http://purl.obolibrary.org/obo/GO_0008162 GO:0008161 biolink:BiologicalProcess obsolete carbamate resistance OBSOLETE. (Was not defined before being made obsolete). go.json carbamate resistance True http://purl.obolibrary.org/obo/GO_0008161 GO:0008160 biolink:MolecularActivity protein tyrosine phosphatase activator activity Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. go.json http://purl.obolibrary.org/obo/GO_0008160 GO:0008129 biolink:MolecularActivity obsolete actinidain activity OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'. go.json actinidain activity|actinidia anionic protease activity|actinidin activity|proteinase A2 of actinidia chinensis True http://purl.obolibrary.org/obo/GO_0008129 GO:0008128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008128 GO:0008127 biolink:MolecularActivity quercetin 2,3-dioxygenase activity Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. EC:1.13.11.24|KEGG_REACTION:R02156|MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN|RHEA:15381|Reactome:R-HSA-8953398|UM-BBD_reactionID:r0891 go.json flavonol 2,4-oxygenase activity|quercetin:oxygen 2,3-oxidoreductase (decyclizing)|quercetinase activity http://purl.obolibrary.org/obo/GO_0008127 GO:0008126 biolink:MolecularActivity acetylesterase activity Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. EC:3.1.1.6|MetaCyc:ACETYLESTERASE-RXN|RHEA:12957|UM-BBD_reactionID:r0170 go.json C-esterase (in animal tissues)|acetic ester hydrolase activity|acetic-ester acetylhydrolase activity|chloroesterase|citrus acetylesterase|p-nitrophenyl acetate esterase http://purl.obolibrary.org/obo/GO_0008126 GO:0008125 biolink:MolecularActivity obsolete pancreatic elastase I activity OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa. go.json elaszym|pancreatic elastase I activity|pancreatopeptidase E activity|serine elastase True http://purl.obolibrary.org/obo/GO_0008125 GO:0008124 biolink:MolecularActivity 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. EC:4.2.1.96|KEGG_REACTION:R04734|MetaCyc:RXN-7908|RHEA:11920|Reactome:R-HSA-71146 go.json (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]|4-alpha-hydroxy-tetrahydropterin dehydratase activity|4a-hydroxytetrahydrobiopterin dehydratase activity|4a-hydroxytetrahydrobiopterin hydro-lyase activity|4alpha-hydroxy-tetrahydropterin dehydratase activity|pterin-4-alpha-carbinolamine dehydratase activity|pterin-4a-carbinolamine dehydratase activity|pterin-4alpha-carbinolamine dehydratase activity|tetrahydrobiopterin dehydratase activity http://purl.obolibrary.org/obo/GO_0008124 GO:0008123 biolink:MolecularActivity cholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. EC:1.14.14.23|MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN|RHEA:21812|Reactome:R-HSA-192051 go.json cholesterol 7-alpha-hydroxylase activity|cholesterol 7alpha-hydroxylase activity|cholesterol 7alpha-monooxygenase activity|cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)|cytochrome P450 CYP7A1 http://purl.obolibrary.org/obo/GO_0008123 GO:0008122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008122 GO:0008121 biolink:MolecularActivity ubiquinol-cytochrome-c reductase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. EC:7.1.1.8|MetaCyc:1.10.2.2-RXN|RHEA:11484|Reactome:R-HSA-164651 go.json complex III (mitochondrial electron transport) activity|cytochrome|cytochrome a|cytochrome a3/copper complex|cytochrome b562|cytochrome b566|cytochrome c1|electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity|electron transporter, transferring electrons within cytochrome c oxidase complex activity|mitochondrial electron transport complex III|soluble cytochrome b562|ubiquinol-cytochrome c oxidoreductase activity|ubiquinol-cytochrome c-2 oxidoreductase activity|ubiquinol-cytochrome c1 oxidoreductase activity|ubiquinol-cytochrome c2 reductase activity|ubiquinol:ferricytochrome-c oxidoreductase activity|ubiquinone--cytochrome-c oxidoreductase activity|ubiquinone-cytochrome c oxidoreductase activity|ubiquinone-cytochrome c reductase activity http://purl.obolibrary.org/obo/GO_0008121 GO:0008120 biolink:MolecularActivity ceramide glucosyltransferase activity Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. EC:2.4.1.80|MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN|RHEA:12088|Reactome:R-HSA-1638104 go.json UDP-glucose-ceramide glucosyltransferase activity|UDP-glucose:N-acylsphingosine D-glucosyltransferase activity|UDP-glucose:ceramide glucosyltransferase activity|UDPglucose:N-acylsphingosine D-glucosyltransferase activity|ceramide:UDP-glucose glucosyltransferase activity|ceramide:UDPGlc glucosyltransferase activity|glucosylceramide synthase activity|uridine diphosphoglucose-ceramide glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0008120 GO:0008130 biolink:MolecularActivity obsolete neutrophil collagenase activity OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I. go.json MMP-8|PMNL collagenase activity|matrix metalloproteinase 8 activity|neutrophil collagenase activity True http://purl.obolibrary.org/obo/GO_0008130 GO:0008139 biolink:MolecularActivity nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. go.json NLS binding|nuclear localisation sequence binding|nuclear localization signal binding http://purl.obolibrary.org/obo/GO_0008139 GO:0008138 biolink:MolecularActivity protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Reactome:R-HSA-5675373|Reactome:R-HSA-5675376|Reactome:R-HSA-9652816 go.json dual-specificity protein phosphatase http://purl.obolibrary.org/obo/GO_0008138 GO:0008137 biolink:MolecularActivity NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). EC:7.1.1.2|MetaCyc:NADH-DEHYDROG-A-RXN|RHEA:29091|Reactome:R-HSA-163217 go.json DPNH-coenzyme Q reductase activity|DPNH-ubiquinone reductase activity|NADH coenzyme Q1 reductase activity|NADH-CoQ oxidoreductase activity|NADH-CoQ reductase activity|NADH-Q6 oxidoreductase activity|NADH-coenzyme Q oxidoreductase activity|NADH-coenzyme Q reductase activity|NADH-ubiquinone oxidoreductase activity|NADH-ubiquinone reductase activity|NADH-ubiquinone-1 reductase activity|NADH:ubiquinone oxidoreductase activity|NADH:ubiquinone oxidoreductase complex activity|coenzyme Q reductase activity|complex 1 dehydrogenase activity|complex I (NADH:Q1 oxidoreductase) activity|complex I (electron transport chain) activity|complex I (mitochondrial electron transport) activity|dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity|electron transfer complex I activity|mitochondrial electron transport complex 1 activity|mitochondrial electron transport complex I activity|reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity|type 1 dehydrogenase activity|ubiquinone reductase activity http://purl.obolibrary.org/obo/GO_0008137 GO:0008136 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008136 GO:0008135 biolink:MolecularActivity translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. go.json translation factor activity, nucleic acid binding http://purl.obolibrary.org/obo/GO_0008135 goslim_chembl|goslim_plant|goslim_yeast GO:0008134 biolink:MolecularActivity transcription factor binding Binding to a transcription factor, a protein required to initiate or regulate transcription. go.json TF binding|transcription regulator binding http://purl.obolibrary.org/obo/GO_0008134 gocheck_do_not_annotate|goslim_agr|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_yeast GO:0008133 biolink:MolecularActivity obsolete collagenase activity OBSOLETE. Was not defined before being made obsolete. go.json collagenase activity True http://purl.obolibrary.org/obo/GO_0008133 GO:0008132 biolink:MolecularActivity obsolete pancreatic elastase activity OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. go.json pancreatic elastase activity True http://purl.obolibrary.org/obo/GO_0008132 GO:0008131 biolink:MolecularActivity primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. EC:1.4.3.21|KEGG_REACTION:R01853|MetaCyc:RXN-9597|Reactome:R-HSA-141186|Reactome:R-HSA-141200|Reactome:R-HSA-141202|Reactome:R-HSA-374909|Reactome:R-HSA-379382|Reactome:R-HSA-379395|Reactome:R-HSA-5603108|Reactome:R-HSA-5696146|Reactome:R-HSA-5696183 go.json amine oxidase (copper-containing) activity|amine oxidase activity|primary-amine:oxygen oxidoreductase (deaminating) activity http://purl.obolibrary.org/obo/GO_0008131 GO:0008141 biolink:MolecularActivity obsolete puparial glue (sensu Diptera) OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147). go.json puparial glue (sensu Diptera) True http://purl.obolibrary.org/obo/GO_0008141 GO:0008140 biolink:MolecularActivity cAMP response element binding protein binding Binding to a cAMP response element binding protein (a CREB protein). go.json 3',5' cAMP response element binding protein binding|3',5'-cAMP response element binding protein binding|CBP|CREB binding|adenosine 3',5'-cyclophosphate response element binding protein binding|cyclic AMP response element binding protein binding http://purl.obolibrary.org/obo/GO_0008140 GO:0008109 biolink:MolecularActivity N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. EC:2.4.1.150|MetaCyc:2.4.1.150-RXN|RHEA:17413 go.json N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity|UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity|galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase http://purl.obolibrary.org/obo/GO_0008109 GO:0008108 biolink:MolecularActivity UDP-glucose:hexose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. EC:2.7.7.12|KEGG_REACTION:R00955|MetaCyc:GALACTURIDYLYLTRANS-RXN|RHEA:13989|Reactome:R-HSA-5610038|Reactome:R-HSA-70361 go.json Gal-1-P uridylyltransferase activity|UDP-glucose-hexose-1-phosphate uridylyltransferase activity|UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity|UDPglucose-hexose-1-phosphate uridylyltransferase activity|UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity|galactose-1-phosphate uridylyltransferase activity|hexose 1-phosphate uridyltransferase activity|hexose-1-phosphate uridylyltransferase activity|uridyl transferase activity|uridyltransferase activity|uridylyl removing enzyme activity http://purl.obolibrary.org/obo/GO_0008108 GO:0008107 biolink:MolecularActivity galactoside 2-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. EC:2.4.1.69|MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN|RHEA:50664|Reactome:R-HSA-9036987|Reactome:R-HSA-9603982|Reactome:R-HSA-9603983 go.json GDP fucose-lactose fucosyltransferase activity|GDP-L-fucose:lactose fucosyltransferase activity|GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity|H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity|H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity|alpha(1,2)-L-fucosyltransferase activity|alpha-(1->2)-L-fucosyltransferase activity|alpha-2-L-fucosyltransferase activity|alpha-2-fucosyltransferase activity|beta-galactoside alpha-1->2 fucosyltransferase activity|beta-galactoside alpha1->2 fucosyltransferase activity|blood group H alpha-2-fucosyltransferase activity|blood-group substance H-dependent fucosyltransferase activity|galactoside 2-L-fucosyltransferase activity|guanosine diphospho-L-fucose-lactose fucosyltransferase activity|guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity|guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity|guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity|guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity|guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity|guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity|guanosine diphosphofucose-lactose fucosyltransferase activity|secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity|secretor-type beta-galactoside alpha1->2 fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0008107 GO:0008106 biolink:MolecularActivity alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. EC:1.1.1.2|MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN|MetaCyc:RXN0-7119|RHEA:15937 go.json NADP-aldehyde reductase activity|alcohol:NADP dehydrogenase activity|aldehyde reductase (NADPH) activity|aldehyde reductase (NADPH2) activity http://purl.obolibrary.org/obo/GO_0008106 GO:0008105 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008105 GO:0008104 biolink:BiologicalProcess protein localization Any process in which a protein is transported to, or maintained in, a specific location. go.json asymmetric protein localisation|asymmetric protein localization|cellular protein localisation|cellular protein localization|channel localizer activity|establishment and maintenance of asymmetric protein localization|establishment and maintenance of protein localization|protein localisation http://purl.obolibrary.org/obo/GO_0008104 goslim_drosophila GO:0008103 biolink:BiologicalProcess oocyte microtubule cytoskeleton polarization Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0008103 GO:0008102 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008102 GO:0008101 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008101 GO:0008100 biolink:MolecularActivity obsolete lipophorin OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects. go.json lipophorin True http://purl.obolibrary.org/obo/GO_0008100 GO:0008119 biolink:MolecularActivity thiopurine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. EC:2.1.1.67|MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN|Reactome:R-HSA-158609|Reactome:R-HSA-5603379|Reactome:R-HSA-9748979|Reactome:R-HSA-9748983 go.json 6-thiopurine transmethylase activity|S-adenosyl-L-methionine:thiopurine S-methyltransferase activity|TPMT|mercaptopurine methyltransferase activity|thiopurine methyltransferase activity http://purl.obolibrary.org/obo/GO_0008119 GO:0008118 biolink:MolecularActivity N-acetyllactosaminide alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein + H+. EC:2.4.3.6|MetaCyc:2.4.99.6-RXN go.json N-acetyllactosaminide alpha-2,3-sialyltransferase|alpha2->3 sialyltransferase activity|cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity http://purl.obolibrary.org/obo/GO_0008118 GO:0008117 biolink:MolecularActivity sphinganine-1-phosphate aldolase activity Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. EC:4.1.2.27|MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN|RHEA:18593|Reactome:R-HSA-428676|Reactome:R-HSA-428681 go.json dihydrosphingosine 1-phosphate aldolase activity|sphinganine-1-phosphate alkanal-lyase activity|sphinganine-1-phosphate lyase activity|sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)|sphinganine-1-phosphate palmitaldehyde-lyase activity|sphingosine-1-phosphate aldolase activity|sphingosine-1-phosphate lyase activity http://purl.obolibrary.org/obo/GO_0008117 GO:0008116 biolink:MolecularActivity prostaglandin-I synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). EC:5.3.99.4|KEGG_REACTION:R02267|MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN|RHEA:23580|Reactome:R-HSA-76496 go.json (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity|PGI(2) synthase activity|PGI(2) synthetase activity|PGI2 synthase activity|PGI2 synthetase activity|cytochrome P450 CYP8A1|prostacyclin synthase activity|prostacycline synthetase activity|prostagladin I2 synthetase activity http://purl.obolibrary.org/obo/GO_0008116 GO:0008115 biolink:MolecularActivity sarcosine oxidase activity Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2. EC:1.5.3.1|KEGG_REACTION:R00610|MetaCyc:SARCOX-RXN|RHEA:13313 go.json sarcosine:oxygen oxidoreductase (demethylating) http://purl.obolibrary.org/obo/GO_0008115 GO:0008114 biolink:MolecularActivity phosphogluconate 2-dehydrogenase activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH. EC:1.1.1.43|MetaCyc:1.1.1.43-RXN go.json 2-keto-6-phosphogluconate reductase activity|6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity|6-phosphogluconate 2-dehydrogenase activity|6-phosphogluconate dehydrogenase (NAD)|6-phosphogluconic dehydrogenase activity|gluconate 6-phosphate dehydrogenase activity|phosphogluconate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008114 GO:0008113 biolink:MolecularActivity peptide-methionine (S)-S-oxide reductase activity Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. EC:1.8.4.11|MetaCyc:RXN-8668|RHEA:14217|Reactome:R-HSA-1222363|Reactome:R-HSA-5676940 go.json MsrA|methionine S-oxide reductase (S-form oxidizing) activity|methionine S-oxide reductase activity|methionine sulfoxide (protein) reductase activity|methionine sulfoxide reductase A activity|methionine sulfoxide reductase activity|methionine sulphoxide reductase A activity|peptide Met(O) reductase activity|peptide methionine sulfoxide reductase activity|peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity|peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-S-oxide reductase activity http://purl.obolibrary.org/obo/GO_0008113 GO:0008112 biolink:MolecularActivity nicotinamide N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. EC:2.1.1.1|KEGG_REACTION:R01269|MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN|RHEA:23884|Reactome:R-HSA-5359451 go.json S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity|nicotinamide methyltransferase activity http://purl.obolibrary.org/obo/GO_0008112 GO:0008111 biolink:MolecularActivity alpha-methylacyl-CoA racemase activity Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. EC:5.1.99.4|MetaCyc:5.1.99.4-RXN|RHEA:12657|Reactome:R-HSA-192056|Reactome:R-HSA-193452|Reactome:R-HSA-193736|Reactome:R-HSA-193763|Reactome:R-HSA-389897 go.json 2-methylacyl-CoA 2-epimerase activity http://purl.obolibrary.org/obo/GO_0008111 GO:0008110 biolink:MolecularActivity L-histidine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate. EC:2.6.1.38|KEGG_REACTION:R01161|MetaCyc:HISTTRANSAM-RXN|RHEA:16565 go.json histidine aminotransferase activity|histidine transaminase activity|histidine-2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0008110 GO:0072694 biolink:BiologicalProcess obsolete cell cycle arrest in response to caffeine OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a caffeine stimulus. go.json True http://purl.obolibrary.org/obo/GO_0072694 GO:0072693 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072693 GO:0072692 biolink:BiologicalProcess obsolete chromatin silencing at centromere central core OBSOLETE. Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin. go.json centromere central core chromatin silencing|chromatin silencing at centromeric central core|chromatin silencing at chromosome kinetochore domain|heterochromatic silencing at centromere central core True http://purl.obolibrary.org/obo/GO_0072692 GO:0072691 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072691 GO:0072690 biolink:BiologicalProcess single-celled organism vegetative growth phase A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods. go.json stationary phase|vegetative growth of a single-celled organism http://purl.obolibrary.org/obo/GO_0072690 gocheck_do_not_annotate GO:0033086 biolink:BiologicalProcess negative regulation of extrathymic T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation. go.json negative regulation of extrathymic T cell development http://purl.obolibrary.org/obo/GO_0033086 GO:0033085 biolink:BiologicalProcess negative regulation of T cell differentiation in thymus Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus. go.json negative regulation of T cell development in thymus|negative regulation of thymic T cell differentiation|negative regulation of thymocyte cell differentiation|negative regulation of thymocyte differentiation http://purl.obolibrary.org/obo/GO_0033085 GO:0033084 biolink:BiologicalProcess regulation of immature T cell proliferation in thymus Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus. go.json regulation of thymic T cell proliferation|regulation of thymocyte cell proliferation|regulation of thymocyte proliferation http://purl.obolibrary.org/obo/GO_0033084 GO:0033083 biolink:BiologicalProcess regulation of immature T cell proliferation Any process that modulates the frequency, rate or extent of immature T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0033083 GO:0033082 biolink:BiologicalProcess regulation of extrathymic T cell differentiation Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation. go.json regulation of extrathymic T cell development http://purl.obolibrary.org/obo/GO_0033082 GO:0033081 biolink:BiologicalProcess regulation of T cell differentiation in thymus Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. go.json regulation of T cell development in thymus|regulation of thymic T cell differentiation|regulation of thymocyte cell differentiation|regulation of thymocyte differentiation http://purl.obolibrary.org/obo/GO_0033081 GO:0033080 biolink:BiologicalProcess immature T cell proliferation in thymus The expansion of an immature T cell population by cell division in the thymus. go.json thymic T cell proliferation|thymocyte cell proliferation|thymocyte proliferation http://purl.obolibrary.org/obo/GO_0033080 GO:0072699 biolink:BiologicalProcess protein localization to cortical microtubule cytoskeleton A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton. go.json protein localisation to cortical microtubule cytoskeleton http://purl.obolibrary.org/obo/GO_0072699 GO:0072698 biolink:BiologicalProcess protein localization to microtubule cytoskeleton A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. go.json protein localisation to microtubule cytoskeleton http://purl.obolibrary.org/obo/GO_0072698 GO:0072697 biolink:BiologicalProcess protein localization to cell cortex A process in which a protein is transported to, or maintained in, the cell cortex. go.json protein localisation to cell cortex http://purl.obolibrary.org/obo/GO_0072697 GO:0033089 biolink:BiologicalProcess positive regulation of T cell differentiation in thymus Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. go.json positive regulation of T cell development in thymus|positive regulation of thymic T cell differentiation|positive regulation of thymocyte cell differentiation|positive regulation of thymocyte differentiation http://purl.obolibrary.org/obo/GO_0033089 GO:0033088 biolink:BiologicalProcess negative regulation of immature T cell proliferation in thymus Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus. go.json negative regulation of thymic T cell proliferation|negative regulation of thymocyte cell proliferation|negative regulation of thymocyte proliferation http://purl.obolibrary.org/obo/GO_0033088 GO:0072696 biolink:BiologicalProcess positive regulation of DNA recombination at telomere Any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere. go.json activation of telomeric recombination at telomere|positive regulation of telomeric recombination|up regulation of telomeric recombination at telomere|up-regulation of telomeric recombination at telomere|upregulation of telomeric recombination at telomere http://purl.obolibrary.org/obo/GO_0072696 GO:0033087 biolink:BiologicalProcess negative regulation of immature T cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0033087 GO:0072695 biolink:BiologicalProcess regulation of DNA recombination at telomere Any process that modulates the frequency, rate or extent of DNA recombination within the telomere. go.json regulation of telomeric recombination http://purl.obolibrary.org/obo/GO_0072695 GO:0072683 biolink:BiologicalProcess T cell extravasation The migration of a T cell from the blood vessels into the surrounding tissue. go.json T lymphocyte extravasation|T-cell extravasation|T-lymphocyte extravasation http://purl.obolibrary.org/obo/GO_0072683 GO:0072682 biolink:BiologicalProcess eosinophil extravasation The migration of an eosinophil from the blood vessels into the surrounding tissue. go.json http://purl.obolibrary.org/obo/GO_0072682 GO:0072681 biolink:BiologicalProcess fibronectin-dependent thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix. go.json fibronectin-dependent immature T cell migration|fibronectin-dependent immature T lymphocyte migration|fibronectin-dependent immature T-cell migration|fibronectin-dependent immature T-lymphocyte migration|fibronectin-dependent thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_0072681 GO:0072680 biolink:BiologicalProcess extracellular matrix-dependent thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin. go.json extracellular matrix-dependent immature T cell migration|extracellular matrix-dependent immature T lymphocyte migration|extracellular matrix-dependent immature T-cell migration|extracellular matrix-dependent immature T-lymphocyte migration|extracellular matrix-dependent thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_0072680 GO:0033075 biolink:BiologicalProcess isoquinoline alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. go.json ipecac alkaloid biosynthesis|isoquinoline alkaloid anabolism|isoquinoline alkaloid biosynthesis|isoquinoline alkaloid formation|isoquinoline alkaloid synthesis http://purl.obolibrary.org/obo/GO_0033075 GO:0033074 biolink:BiologicalProcess pinene catabolic process The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane. go.json pinene breakdown|pinene catabolism|pinene degradation http://purl.obolibrary.org/obo/GO_0033074 GO:0033073 biolink:BiologicalProcess pinene metabolic process The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane. go.json pinene metabolism http://purl.obolibrary.org/obo/GO_0033073 GO:0033072 biolink:BiologicalProcess vancomycin biosynthetic process The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. go.json vancomycin anabolism|vancomycin biosynthesis|vancomycin formation|vancomycin synthesis http://purl.obolibrary.org/obo/GO_0033072 GO:0033071 biolink:BiologicalProcess vancomycin metabolic process The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. go.json vancomycin metabolism http://purl.obolibrary.org/obo/GO_0033071 GO:0033070 biolink:BiologicalProcess ansamycin biosynthetic process The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity. go.json ansamycin anabolism|ansamycin biosynthesis|ansamycin formation|ansamycin synthesis http://purl.obolibrary.org/obo/GO_0033070 GO:0072689 biolink:BiologicalProcess MCM complex assembly The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication. go.json http://purl.obolibrary.org/obo/GO_0072689 GO:0072688 biolink:BiologicalProcess SHREC complex localization Any process in which a SHREC complex is transported to, or maintained in, a specific location. go.json SHREC complex localisation|establishment and maintenance of SHREC complex localization http://purl.obolibrary.org/obo/GO_0072688 GO:0072687 biolink:CellularComponent meiotic spindle A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. go.json http://purl.obolibrary.org/obo/GO_0072687 GO:0033079 biolink:BiologicalProcess immature T cell proliferation The expansion of an immature T cell population by cell division. go.json http://purl.obolibrary.org/obo/GO_0033079 GO:0033078 biolink:BiologicalProcess extrathymic T cell differentiation The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus. go.json extrathymic T cell development http://purl.obolibrary.org/obo/GO_0033078 GO:0072686 biolink:CellularComponent mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. go.json http://purl.obolibrary.org/obo/GO_0072686 GO:0072685 biolink:BiologicalProcess Mre11 complex assembly The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling. go.json MRN complex assembly|MRX complex assembly|RAD50-MRE11-NBN complex assembly|RMX complex assembly|Rad50 complex assembly|Rad50-Rad32-Nbs1 complex assembly http://purl.obolibrary.org/obo/GO_0072685 GO:0033077 biolink:BiologicalProcess T cell differentiation in thymus The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. go.json T cell development in thymus|thymic T cell differentiation|thymocyte cell differentiation|thymocyte differentiation http://purl.obolibrary.org/obo/GO_0033077 GO:0072684 biolink:BiologicalProcess obsolete mitochondrial tRNA 3'-trailer cleavage, endonucleolytic OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion. go.json mitochondrial endonucleolytic tRNA 3'-end cleavage|mitochondrial endonucleolytic tRNA 3'-trailer cleavage|mitochondrial tRNA 3'-end cleavage, endonucleolytic True http://purl.obolibrary.org/obo/GO_0072684 GO:0033076 biolink:BiologicalProcess isoquinoline alkaloid metabolic process The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. go.json ipecac alkaloid metabolism|isoquinoline alkaloid metabolism http://purl.obolibrary.org/obo/GO_0033076 GO:0033064 biolink:CellularComponent XRCC2-RAD51D complex A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast. go.json DX2 complex http://purl.obolibrary.org/obo/GO_0033064 GO:0033063 biolink:CellularComponent Rad51B-Rad51C-Rad51D-XRCC2 complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof. go.json BCDX2 complex http://purl.obolibrary.org/obo/GO_0033063 GO:0033062 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033062 GO:0033061 biolink:CellularComponent DNA recombinase mediator complex A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange. go.json http://purl.obolibrary.org/obo/GO_0033061 goslim_pir GO:0033060 biolink:BiologicalProcess ocellus pigmentation The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates. go.json http://purl.obolibrary.org/obo/GO_0033060 GO:0033069 biolink:BiologicalProcess ansamycin metabolic process The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity. go.json ansamycin metabolism http://purl.obolibrary.org/obo/GO_0033069 GO:0033068 biolink:BiologicalProcess macrolide biosynthetic process The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria. go.json macrolide anabolism|macrolide biosynthesis|macrolide formation|macrolide synthesis http://purl.obolibrary.org/obo/GO_0033068 GO:0033067 biolink:BiologicalProcess macrolide metabolic process The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria. go.json macrolide metabolism http://purl.obolibrary.org/obo/GO_0033067 GO:0033066 biolink:CellularComponent Rad51B-Rad51C complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof. go.json BC complex http://purl.obolibrary.org/obo/GO_0033066 GO:0033065 biolink:CellularComponent Rad51C-XRCC3 complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof. go.json CX3 complex|Rad55-Rad57 complex|Rhp55-Rhp57 complex http://purl.obolibrary.org/obo/GO_0033065 GO:0033053 biolink:BiologicalProcess D-glutamine metabolic process The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid. go.json D-glutamine metabolism http://purl.obolibrary.org/obo/GO_0033053 GO:0033052 biolink:BiologicalProcess cyanoamino acid metabolic process The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group. go.json cyanoamino acid metabolism http://purl.obolibrary.org/obo/GO_0033052 GO:0033051 biolink:BiologicalProcess aminophosphonate metabolic process The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group. KEGG_PATHWAY:map00440 go.json aminophosphonate metabolism http://purl.obolibrary.org/obo/GO_0033051 GO:0033050 biolink:BiologicalProcess clavulanic acid biosynthetic process The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Wikipedia:Clavulanic_acid go.json clavulanic acid anabolism|clavulanic acid biosynthesis|clavulanic acid formation|clavulanic acid synthesis http://purl.obolibrary.org/obo/GO_0033050 GO:0033059 biolink:BiologicalProcess cellular pigmentation The deposition or aggregation of coloring matter in a cell. go.json http://purl.obolibrary.org/obo/GO_0033059 GO:0033058 biolink:BiologicalProcess directional locomotion Self-propelled movement of a cell or organism from one location to another along an axis. go.json http://purl.obolibrary.org/obo/GO_0033058 GO:0033057 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033057 GO:0033056 biolink:BiologicalProcess D-ornithine metabolic process The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid. go.json D-ornithine metabolism http://purl.obolibrary.org/obo/GO_0033056 GO:0033055 biolink:BiologicalProcess D-arginine metabolic process The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid. go.json D-arginine metabolism http://purl.obolibrary.org/obo/GO_0033055 GO:0033054 biolink:BiologicalProcess D-glutamate metabolic process The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid. go.json D-glutamate metabolism http://purl.obolibrary.org/obo/GO_0033054 GO:0008089 biolink:BiologicalProcess anterograde axonal transport The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. go.json anterograde axon cargo transport http://purl.obolibrary.org/obo/GO_0008089 goslim_synapse GO:0008088 biolink:BiologicalProcess axo-dendritic transport The directed movement of organelles or molecules along microtubules in neuron projections. Wikipedia:Axoplasmic_transport go.json axon cargo transport|axonal transport|axoplasmic transport http://purl.obolibrary.org/obo/GO_0008088 goslim_synapse GO:0008087 biolink:CellularComponent light-activated voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus. go.json light-activated voltage gated calcium channel complex|light-activated voltage-dependent calcium channel complex|light-activated voltage-sensitive calcium channel complex http://purl.obolibrary.org/obo/GO_0008087 GO:0008097 biolink:MolecularActivity 5S rRNA binding Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. go.json http://purl.obolibrary.org/obo/GO_0008097 GO:0033042 biolink:MolecularActivity umami taste receptor activity Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates. go.json http://purl.obolibrary.org/obo/GO_0033042 GO:0008096 biolink:MolecularActivity juvenile hormone epoxide hydrolase activity Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol. EC:3.3.2.- go.json http://purl.obolibrary.org/obo/GO_0008096 GO:0033041 biolink:MolecularActivity sweet taste receptor activity Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste. go.json http://purl.obolibrary.org/obo/GO_0033041 GO:0008095 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008095 GO:0033040 biolink:MolecularActivity sour taste receptor activity Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste. go.json http://purl.obolibrary.org/obo/GO_0033040 GO:0008094 biolink:MolecularActivity ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. go.json ATPase activity, acting on DNA|ATPase, acting on DNA|DNA dependent ATPase activity|DNA-dependent ATPase activity|DNA-dependent adenosinetriphosphatase activity|adenosinetriphosphatase (DNA-dependent) http://purl.obolibrary.org/obo/GO_0008094 GO:0008093 biolink:MolecularActivity cytoskeletal anchor activity The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. go.json cytoskeletal adaptor activity http://purl.obolibrary.org/obo/GO_0008093 GO:0008092 biolink:MolecularActivity cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). go.json http://purl.obolibrary.org/obo/GO_0008092 goslim_agr|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_yeast|prokaryote_subset GO:0008091 biolink:CellularComponent spectrin Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. NIF_Subcellular:sao536287099|Wikipedia:Spectrin go.json http://purl.obolibrary.org/obo/GO_0008091 GO:0008090 biolink:BiologicalProcess retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. go.json retrograde axon cargo transport http://purl.obolibrary.org/obo/GO_0008090 goslim_synapse GO:0033049 biolink:BiologicalProcess clavulanic acid metabolic process The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. go.json clavulanic acid metabolism http://purl.obolibrary.org/obo/GO_0033049 GO:0033048 biolink:BiologicalProcess negative regulation of mitotic sister chromatid segregation Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. go.json http://purl.obolibrary.org/obo/GO_0033048 GO:0033047 biolink:BiologicalProcess regulation of mitotic sister chromatid segregation Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. go.json http://purl.obolibrary.org/obo/GO_0033047 GO:0033046 biolink:BiologicalProcess negative regulation of sister chromatid segregation Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. go.json http://purl.obolibrary.org/obo/GO_0033046 GO:0033045 biolink:BiologicalProcess regulation of sister chromatid segregation Any process that modulates the frequency, rate or extent of sister chromatid segregation. go.json http://purl.obolibrary.org/obo/GO_0033045 GO:0033044 biolink:BiologicalProcess regulation of chromosome organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. go.json regulation of chromosome organisation|regulation of chromosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0033044 GO:0033043 biolink:BiologicalProcess regulation of organelle organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. go.json regulation of organelle organisation|regulation of organelle organization and biogenesis http://purl.obolibrary.org/obo/GO_0033043 goslim_yeast GO:0008099 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008099 GO:0008098 biolink:MolecularActivity 5S rRNA primary transcript binding Binding to an unprocessed 5S ribosomal RNA transcript. go.json http://purl.obolibrary.org/obo/GO_0008098 GO:0033031 biolink:BiologicalProcess positive regulation of neutrophil apoptotic process Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process. go.json activation of neutrophil apoptosis|positive regulation of neutrophil apoptosis|stimulation of neutrophil apoptosis|up regulation of neutrophil apoptosis|up-regulation of neutrophil apoptosis|upregulation of neutrophil apoptosis http://purl.obolibrary.org/obo/GO_0033031 GO:0033030 biolink:BiologicalProcess negative regulation of neutrophil apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process. go.json down regulation of neutrophil apoptosis|down-regulation of neutrophil apoptosis|downregulation of neutrophil apoptosis|inhibition of neutrophil apoptosis|negative regulation of neutrophil apoptosis http://purl.obolibrary.org/obo/GO_0033030 GO:0033039 biolink:MolecularActivity ionotropic salty taste receptor activity Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0033039 GO:0033038 biolink:MolecularActivity bitter taste receptor activity Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. go.json http://purl.obolibrary.org/obo/GO_0033038 GO:0033037 biolink:BiologicalProcess polysaccharide localization Any process in which a polysaccharide is transported to, or maintained in, a specific location. go.json polysaccharide localisation http://purl.obolibrary.org/obo/GO_0033037 GO:0033036 biolink:BiologicalProcess macromolecule localization Any process in which a macromolecule is transported to, or maintained in, a specific location. go.json macromolecule localisation http://purl.obolibrary.org/obo/GO_0033036 goslim_flybase_ribbon GO:0033035 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033035 GO:0033034 biolink:BiologicalProcess positive regulation of myeloid cell apoptotic process Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. go.json activation of myeloid cell apoptosis|positive regulation of myeloid cell apoptosis|stimulation of myeloid cell apoptosis|up regulation of myeloid cell apoptosis|up-regulation of myeloid cell apoptosis|upregulation of myeloid cell apoptosis http://purl.obolibrary.org/obo/GO_0033034 GO:0033033 biolink:BiologicalProcess negative regulation of myeloid cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. go.json down regulation of myeloid cell apoptosis|down-regulation of myeloid cell apoptosis|downregulation of myeloid cell apoptosis|inhibition of myeloid cell apoptosis|negative regulation of myeloid cell apoptosis http://purl.obolibrary.org/obo/GO_0033033 GO:0033032 biolink:BiologicalProcess regulation of myeloid cell apoptotic process Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. go.json regulation of myeloid cell apoptosis http://purl.obolibrary.org/obo/GO_0033032 GO:0033029 biolink:BiologicalProcess regulation of neutrophil apoptotic process Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process. go.json regulation of neutrophil apoptosis http://purl.obolibrary.org/obo/GO_0033029 GO:0008069 biolink:BiologicalProcess dorsal/ventral axis specification, ovarian follicular epithelium Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster. go.json dorsal-ventral axis specification, ovarian follicular epithelium|dorsal/ventral axis determination, follicular epithelium|dorsal/ventral axis determination, ovarian follicular epithelium|dorsoventral axis specification, ovarian follicular epithelium http://purl.obolibrary.org/obo/GO_0008069 GO:0008068 biolink:MolecularActivity extracellularly glutamate-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. go.json extracellular-glutamate-gated chloride channel activity http://purl.obolibrary.org/obo/GO_0008068 GO:0008067 biolink:MolecularActivity obsolete metabotropic glutamate, GABA-B-like receptor activity OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor. go.json class C G protein coupled receptor|class C G-protein coupled receptor|class C GPCR|class C orphan receptor activity|metabotropic glutamate, GABA-B-like receptor activity True http://purl.obolibrary.org/obo/GO_0008067 GO:0008066 biolink:MolecularActivity glutamate receptor activity Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0008066 GO:0008065 biolink:BiologicalProcess establishment of blood-nerve barrier The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier. go.json establishment of blood/nerve barrier http://purl.obolibrary.org/obo/GO_0008065 GO:0008075 biolink:MolecularActivity obsolete receptor guanylate cyclase activity OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. go.json receptor guanylate cyclase activity True http://purl.obolibrary.org/obo/GO_0008075 GO:0033020 biolink:BiologicalProcess cyclopentanol metabolic process The chemical reactions and pathways involving cyclopentanol. go.json cyclopentanol metabolism http://purl.obolibrary.org/obo/GO_0033020 GO:0008074 biolink:CellularComponent guanylate cyclase complex, soluble Complex that possesses guanylate cyclase activity and is not bound to a membrane. go.json http://purl.obolibrary.org/obo/GO_0008074 GO:0008073 biolink:MolecularActivity ornithine decarboxylase inhibitor activity Binds to and stops, prevents or reduces the activity of ornithine decarboxylase. go.json http://purl.obolibrary.org/obo/GO_0008073 GO:0008072 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008072 GO:0008071 biolink:BiologicalProcess maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster. go.json maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded|maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded|maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded http://purl.obolibrary.org/obo/GO_0008071 GO:0008070 biolink:BiologicalProcess maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line. go.json maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded|maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded http://purl.obolibrary.org/obo/GO_0008070 GO:0033028 biolink:BiologicalProcess myeloid cell apoptotic process Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. go.json apoptosis of myeloid cells|myeloid cell apoptosis http://purl.obolibrary.org/obo/GO_0033028 GO:0033027 biolink:BiologicalProcess positive regulation of mast cell apoptotic process Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process. go.json activation of mast cell apoptosis|positive regulation of mast cell apoptosis|stimulation of mast cell apoptosis|up regulation of mast cell apoptosis|up-regulation of mast cell apoptosis|upregulation of mast cell apoptosis http://purl.obolibrary.org/obo/GO_0033027 GO:0033026 biolink:BiologicalProcess negative regulation of mast cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. go.json down regulation of mast cell apoptosis|down-regulation of mast cell apoptosis|downregulation of mast cell apoptosis|inhibition of mast cell apoptosis|negative regulation of mast cell apoptosis http://purl.obolibrary.org/obo/GO_0033026 GO:0033025 biolink:BiologicalProcess regulation of mast cell apoptotic process Any process that modulates the frequency, rate, or extent of mast cell apoptotic process. go.json regulation of mast cell apoptosis http://purl.obolibrary.org/obo/GO_0033025 GO:0033024 biolink:BiologicalProcess mast cell apoptotic process Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. go.json apoptosis of mast cells|mast cell apoptosis http://purl.obolibrary.org/obo/GO_0033024 GO:0033023 biolink:BiologicalProcess mast cell homeostasis The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json http://purl.obolibrary.org/obo/GO_0033023 GO:0033022 biolink:BiologicalProcess cyclopentanol catabolic process The chemical reactions and pathways resulting in the breakdown of cyclopentanol. go.json cyclopentanol breakdown|cyclopentanol catabolism|cyclopentanol degradation http://purl.obolibrary.org/obo/GO_0033022 GO:0033021 biolink:BiologicalProcess cyclopentanol biosynthetic process The chemical reactions and pathways resulting in the formation of cyclopentanol. go.json cyclopentanol anabolism|cyclopentanol biosynthesis|cyclopentanol formation|cyclopentanol synthesis http://purl.obolibrary.org/obo/GO_0033021 GO:0033019 biolink:MolecularActivity 5-hydroxyvalerate dehydrogenase activity Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH. go.json http://purl.obolibrary.org/obo/GO_0033019 GO:0033018 biolink:CellularComponent sarcoplasmic reticulum lumen The volume enclosed by the membranes of the sarcoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0033018 GO:0008079 biolink:MolecularActivity translation termination factor activity Functions in the termination of translation. go.json http://purl.obolibrary.org/obo/GO_0008079 GO:0008078 biolink:BiologicalProcess mesodermal cell migration The orderly movement of mesodermal cells from one site to another. go.json mesoderm cell migration http://purl.obolibrary.org/obo/GO_0008078 GO:0008077 biolink:MolecularActivity obsolete Hsp70/Hsp90 organizing protein activity OBSOLETE. (Was not defined before being made obsolete). go.json Hsp70/Hsp90 organising protein activity|Hsp70/Hsp90 organizing protein activity True http://purl.obolibrary.org/obo/GO_0008077 GO:0008076 biolink:CellularComponent voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. NIF_Subcellular:sao371494298 go.json voltage gated potassium channel complex|voltage-dependent potassium channel complex|voltage-sensitive potassium channel complex http://purl.obolibrary.org/obo/GO_0008076 GO:0008086 biolink:MolecularActivity light-activated voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json light-activated voltage gated calcium channel activity|light-activated voltage-dependent calcium channel activity http://purl.obolibrary.org/obo/GO_0008086 GO:0008085 biolink:BiologicalProcess obsolete phototransduction, visible light, light adaptation OBSOLETE. (Was not defined before being made obsolete). go.json phototransduction, visible light, light adaptation True http://purl.obolibrary.org/obo/GO_0008085 GO:0008084 biolink:MolecularActivity imaginal disc growth factor receptor binding Binding to an imaginal disc growth factor receptor. go.json imaginal disc growth factor http://purl.obolibrary.org/obo/GO_0008084 GO:0008083 biolink:MolecularActivity growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. go.json http://purl.obolibrary.org/obo/GO_0008083 goslim_chembl GO:0008081 biolink:MolecularActivity phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. EC:3.1.4.-|Reactome:R-HSA-5693578 go.json phosphodiesterase http://purl.obolibrary.org/obo/GO_0008081 goslim_chembl GO:0008080 biolink:MolecularActivity N-acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. Reactome:R-HSA-2468039|Reactome:R-HSA-2473152|Reactome:R-HSA-6790987|Reactome:R-HSA-9636560 go.json http://purl.obolibrary.org/obo/GO_0008080 GO:0033017 biolink:CellularComponent sarcoplasmic reticulum membrane The lipid bilayer surrounding the sarcoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0033017 GO:0033016 biolink:CellularComponent rhoptry membrane The lipid bilayer surrounding a rhoptry. go.json http://purl.obolibrary.org/obo/GO_0033016 GO:0033015 biolink:BiologicalProcess tetrapyrrole catabolic process The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. go.json tetrapyrrole breakdown|tetrapyrrole catabolism|tetrapyrrole degradation http://purl.obolibrary.org/obo/GO_0033015 GO:0033014 biolink:BiologicalProcess tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. go.json tetrapyrrole anabolism|tetrapyrrole biosynthesis|tetrapyrrole formation|tetrapyrrole synthesis http://purl.obolibrary.org/obo/GO_0033014 GO:0033013 biolink:BiologicalProcess tetrapyrrole metabolic process The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. go.json tetrapyrrole metabolism http://purl.obolibrary.org/obo/GO_0033013 goslim_pombe|prokaryote_subset GO:0033012 biolink:CellularComponent porosome A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles. Wikipedia:Porosome go.json http://purl.obolibrary.org/obo/GO_0033012 GO:0033011 biolink:CellularComponent perinuclear theca A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins. go.json http://purl.obolibrary.org/obo/GO_0033011 GO:0033010 biolink:CellularComponent paranodal junction A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. go.json axoglial septate junction|paranodal axoglial junction|paranodal septate junction http://purl.obolibrary.org/obo/GO_0033010 GO:0047650 biolink:MolecularActivity alkylglycerone kinase activity Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H+. EC:2.7.1.84|KEGG_REACTION:R03944|MetaCyc:ALKYLGLYCERONE-KINASE-RXN|RHEA:23088 go.json ATP:O-alkylglycerone phosphotransferase activity|alkyldihydroxyacetone kinase (phosphorylating)|alkyldihydroxyacetone kinase activity http://purl.obolibrary.org/obo/GO_0047650 GO:0047658 biolink:MolecularActivity alpha-amino-acid esterase activity Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol. EC:3.1.1.43|MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN|RHEA:17241|Reactome:R-HSA-6784959 go.json a-amino-acid esterase activity|alpha-amino acid ester hydrolase activity|alpha-amino-acid ester hydrolase activity|alpha-amino-acid-ester aminoacylhydrolase activity http://purl.obolibrary.org/obo/GO_0047658 GO:0141039 biolink:MolecularActivity phosphatidylinositol 3-kinase inhibitor activity Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K). go.json http://purl.obolibrary.org/obo/GO_0141039 GO:0047657 biolink:MolecularActivity alpha-1,3-glucan synthase activity Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1. EC:2.4.1.183|MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN|RHEA:19749 go.json 1,3-alpha-D-glucan synthase activity|1,3-alpha-glucan synthase activity|UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity|UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity|a-1,3-glucan synthase activity|uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047657 GO:0141038 biolink:MolecularActivity phosphatidylinositol 3-kinase activator activity Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K). go.json http://purl.obolibrary.org/obo/GO_0141038 GO:0047656 biolink:MolecularActivity alpha,alpha-trehalose phosphorylase activity Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate. EC:2.4.1.64|MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN|RHEA:23512 go.json a,a-trehalose phosphorylase activity|alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity|trehalose phosphorylase http://purl.obolibrary.org/obo/GO_0047656 GO:0047655 biolink:MolecularActivity allyl-alcohol dehydrogenase activity Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH. EC:1.1.1.54|KEGG_REACTION:R03572|MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN|RHEA:12168 go.json allyl-alcohol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047655 GO:0047654 biolink:MolecularActivity alliin lyase activity Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate. EC:4.4.1.4|MetaCyc:ALLIIN-LYASE-RXN|RHEA:20141 go.json L-cysteine sulfoxide lyase activity|S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)|S-alkylcysteine sulfoxide lyase activity|alkylcysteine sulfoxide lyase activity|alliin alkyl-sulfenate-lyase activity|alliinase activity|cysteine sulfoxide lyase activity|cysteine sulphoxide lyase activity http://purl.obolibrary.org/obo/GO_0047654 GO:0047653 biolink:MolecularActivity allantoin racemase activity Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin. EC:5.1.99.3|KEGG_REACTION:R03925|MetaCyc:ALLANTOIN-RACEMASE-RXN|RHEA:10804 go.json http://purl.obolibrary.org/obo/GO_0047653 GO:0047652 biolink:MolecularActivity allantoate deiminase activity Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine. EC:3.5.3.9|MetaCyc:ALLANTOATE-DEIMINASE-RXN|RHEA:27485 go.json allantoate amidinohydrolase (decarboxylating)|allantoate amidohydrolase activity http://purl.obolibrary.org/obo/GO_0047652 GO:0047651 biolink:MolecularActivity alkylhalidase activity Catalysis of the reaction: bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H+. KEGG_REACTION:R03523|RHEA:13765 go.json alkyl-halide halidohydrolase activity|haloalkane halidohydrolase activity|halogenase activity http://purl.obolibrary.org/obo/GO_0047651 GO:0141031 biolink:BiologicalProcess symbiont-mediated perturbation of host actin cytoskeleton via actin crosslinking The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by actin crosslinking the host actin filaments. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json perturbation by symbiont of host actin cytoskeleton via actin crosslinking http://purl.obolibrary.org/obo/GO_0141031 GO:0141030 biolink:BiologicalProcess symbiont-mediated perturbation of host actin cytoskeleton via filamentous actin depolymerization The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by depolymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141030 GO:0141033 biolink:BiologicalProcess symbiont-mediated perturbation of host actin cytoskeleton via actin polymerization The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by polymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json perturbation by symbiont of host actin cytoskeleton via actin polymerization http://purl.obolibrary.org/obo/GO_0141033 GO:0141032 biolink:BiologicalProcess symbiont-mediated perturbation of host actin cytoskeleton via actin filament reorganization The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by reorganizing the actin filaments, in a way that keeps the total filementous actin remains approximately constant. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json perturbation by symbiont of host actin cytoskeleton via actin filament rearrangement|perturbation by symbiont of host actin cytoskeleton via actin filament reorganization http://purl.obolibrary.org/obo/GO_0141032 GO:0072619 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072619 GO:0141035 biolink:MolecularActivity CTP-dependent diacylglycerol kinase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+. EC:2.7.1.174|KEGG_REACTION:R09944|MetaCyc:RXN-12959|RHEA:25948 go.json DAG kinase activity|diacylglycerol kinase (CTP dependent)|diacylglycerol kinase activity|diacylglycerol kinase activity (CTP) http://purl.obolibrary.org/obo/GO_0141035 GO:0072618 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072618 GO:0141034 biolink:BiologicalProcess symbiont-mediated perturbation of host actin cytoskeleton via inhibition of actin polymerization The process in which an organism effects a change that disrupts the host actin cytoskeleton by inhibiting host actin from polymerizing. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json perturbation by symbiont of host actin cytoskeleton via inhibition of actin polymerization http://purl.obolibrary.org/obo/GO_0141034 GO:0072617 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072617 GO:0072616 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072616 GO:0047659 biolink:MolecularActivity alpha-santonin 1,2-reductase activity Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+. EC:1.3.1.47|MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN go.json 1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity|a-santonin 1,2-reductase activity http://purl.obolibrary.org/obo/GO_0047659 GO:0072615 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072615 GO:0072614 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072614 GO:0072613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072613 GO:0072612 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072612 GO:0072611 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072611 GO:0072610 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072610 GO:0047661 biolink:MolecularActivity amino-acid racemase activity Catalysis of the reaction: an L-amino acid = a D-amino acid. EC:5.1.1.10|MetaCyc:AMINO-ACID-RACEMASE-RXN|RHEA:18317 go.json L-amino acid racemase activity http://purl.obolibrary.org/obo/GO_0047661 GO:0047660 biolink:MolecularActivity amidinoaspartase activity Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea. EC:3.5.3.14|KEGG_REACTION:R00777|MetaCyc:AMIDINOASPARTASE-RXN|RHEA:14849 go.json N-amidino-L-aspartate amidinohydrolase activity|amidinoaspartic amidinohydrolase activity http://purl.obolibrary.org/obo/GO_0047660 GO:0141028 biolink:BiologicalProcess symbiont-mediated perturbation of host microtubule cytoskeleton The process in which an organism effects a change that impairs the structure or function of the host microtubule cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host microtubule cytoskeleton|modification by symbiont of host microtubule cytoskeleton|perturbation by symbiont of host microtubule cytoskeleton http://purl.obolibrary.org/obo/GO_0141028 GO:0047669 biolink:MolecularActivity amylosucrase activity Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1). EC:2.4.1.4|MetaCyc:AMYLOSUCRASE-RXN|RHEA:24572 go.json sucrose-1,4-alpha-glucan glucosyltransferase activity|sucrose-glucan glucosyltransferase activity|sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047669 GO:0047668 biolink:MolecularActivity amygdalin beta-glucosidase activity Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose. EC:3.2.1.117|KEGG_REACTION:R02985|MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN|RHEA:14177 go.json (R)-amygdalin beta-glucosidase activity|amygdalin b-glucosidase activity|amygdalin beta-D-glucohydrolase activity|amygdalin glucosidase activity|amygdalin hydrolase activity|amygdalinase http://purl.obolibrary.org/obo/GO_0047668 GO:0141027 biolink:BiologicalProcess symbiont-mediated perturbation of host actin cytoskeleton The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of actin cytoskeleton|modification by symbiont of host actin cytoskeleton|perturbation by symbiont of host actin cytoskeleton http://purl.obolibrary.org/obo/GO_0141027 GO:0047667 biolink:MolecularActivity AMP-thymidine kinase activity Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate. EC:2.7.1.114|MetaCyc:AMP--THYMIDINE-KINASE-RXN|RHEA:14913 go.json AMP:dThd kinase activity|AMP:deoxythymidine 5'-phosphotransferase activity|AMP:deoxythymidine kinase activity|AMP:thymidine 5'-phosphotransferase activity|adenylate-nucleoside phosphotransferase activity|adenylic acid:deoxythymidine 5'-phosphotransferase activity|thymidine phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047667 GO:0047666 biolink:MolecularActivity ammonia kinase activity Catalysis of the reaction: ATP + NH4 = ADP + 3 H+ + phosphoramidate. EC:2.7.3.8|KEGG_REACTION:R00141|MetaCyc:AMMONIA-KINASE-RXN|RHEA:11024 go.json ATP:ammonia phosphotransferase activity|phosphoramidate-ADP-phosphotransferase activity|phosphoramidate-adenosine diphosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047666 GO:0141029 biolink:BiologicalProcess disruption by symbiont of host focal adhesion The process by which a symbiont disupts host focal adhesion in its host. go.json http://purl.obolibrary.org/obo/GO_0141029 GO:0047665 biolink:MolecularActivity aminolevulinate transaminase activity Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine. EC:2.6.1.43|KEGG_REACTION:R02271|MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN|RHEA:12480 go.json 4,5-dioxovalerate aminotransferase activity|4,5-dioxovaleric acid aminotransferase activity|4,5-dioxovaleric acid transaminase activity|4,5-dioxovaleric transaminase activity|5-aminolevulinate:pyruvate aminotransferase activity|5-aminolevulinic acid transaminase activity|DOVA transaminase activity|L-alanine-4,5-dioxovalerate aminotransferase activity|L-alanine:4,5-dioxovaleric acid transaminase activity|L-alanine:dioxovalerate transaminase activity|alanine-dioxovalerate aminotransferase activity|alanine-gamma,delta-dioxovalerate aminotransferase activity|alanine:4,5-dioxovalerate aminotransferase activity|aminolevulinate aminotransferase activity|aminolevulinic acid transaminase activity|dioxovalerate transaminase activity|gamma,delta-dioxovalerate aminotransferase activity|gamma,delta-dioxovaleric acid transaminase activity http://purl.obolibrary.org/obo/GO_0047665 GO:0047664 biolink:MolecularActivity aminoimidazolase activity Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH3. EC:3.5.4.8|MetaCyc:R13-RXN|RHEA:22348 go.json 4-aminoimidazole aminohydrolase activity|4-aminoimidazole hydrolase activity http://purl.obolibrary.org/obo/GO_0047664 GO:0047663 biolink:MolecularActivity aminoglycoside 6'-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring. EC:2.3.1.82|KEGG_REACTION:R01889|MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN|RHEA:16449 go.json 6'-aminoglycoside-N-acetyltransferase activity|AAC(6') activity|acetyl-CoA:kanamycin-B N6'-acetyltransferase activity|aminoglycoside N6'-acetyltransferase activity|aminoglycoside-6'-acetyltransferase activity|aminoglycoside-6-N-acetyltransferase activity|kanamycin 6'-N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047663 GO:0047662 biolink:MolecularActivity aminobenzoate decarboxylase activity Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2. EC:4.1.1.24|MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN|RHEA:24200 go.json aminobenzoate carboxy-lyase (aniline-forming)|aminobenzoate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047662 GO:0072609 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072609 GO:0072608 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072608 GO:0141024 biolink:BiologicalProcess adhesion of symbiont to host cell surface via host membrane carbohydrate The attachment of a symbiont to its host by binding to a carbohydrate on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141024 GO:0072607 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072607 GO:0141023 biolink:BiologicalProcess disruption by symbiont of host cell-cell adhesion The process by which a symbiont disupts cell-cell adhesion in its host. go.json http://purl.obolibrary.org/obo/GO_0141023 GO:0072606 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072606 GO:0141026 biolink:BiologicalProcess adhesion of symbiont to host cell surface via host membrane cholesterol The attachment of a symbiont to its host by binding to cholesterol on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141026 GO:0072605 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072605 GO:0141025 biolink:BiologicalProcess adhesion of symbiont to host cell surface via host glycoprotein The attachment of a symbiont to its host by binding to a glycoprotein on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141025 GO:0072604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072604 GO:0072603 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072603 GO:0072602 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072602 GO:0072601 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072601 GO:0072600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072600 GO:0047672 biolink:MolecularActivity anthranilate N-benzoyltransferase activity Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA. EC:2.3.1.144|KEGG_REACTION:R02453|MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN|RHEA:21600 go.json benzoyl-CoA:anthranilate N-benzoyltransferase http://purl.obolibrary.org/obo/GO_0047672 GO:0047671 biolink:MolecularActivity cyclopeptine synthase activity Catalysis of the reaction: anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine. EC:6.3.2.40|KEGG_REACTION:R00979|MetaCyc:RXN-13989|RHEA:35091 go.json ATP:anthranilate adenylyltransferase activity|anthranilate adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0047671 GO:0047670 biolink:MolecularActivity anhydrotetracycline monooxygenase activity Catalysis of the reaction: anhydrotetracycline + H+ + NADPH + O2 = 12-dehydrotetracycline + H2O + NADP+. EC:1.14.13.38|KEGG_REACTION:R04060|MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN|RHEA:11976 go.json ATC oxygenase activity|anhydrotetracycline oxygenase activity|anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating) http://purl.obolibrary.org/obo/GO_0047670 GO:0047679 biolink:MolecularActivity arginine racemase activity Catalysis of the reaction: L-arginine = D-arginine. EC:5.1.1.9|MetaCyc:ARGININE-RACEMASE-RXN|RHEA:18069 go.json http://purl.obolibrary.org/obo/GO_0047679 GO:0047678 biolink:MolecularActivity arginine 2-monooxygenase activity Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O. EC:1.13.12.1|KEGG_REACTION:R00559|MetaCyc:ARGININE-2-MONOOXYGENASE-RXN|RHEA:10548 go.json L-arginine:oxygen 2-oxidoreductase (decarboxylating)|arginine decarboxy-oxidase activity|arginine monooxygenase activity|arginine oxygenase (decarboxylating) activity http://purl.obolibrary.org/obo/GO_0047678 GO:0047677 biolink:MolecularActivity arachidonate 8(R)-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. EC:1.13.11.40|KEGG_REACTION:R01594|MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN|RHEA:14985 go.json 8(R)-lipoxygenase activity|8-lipoxygenase activity|arachidonate 8-lipoxygenase activity|arachidonate:oxygen 8-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047677 GO:0047676 biolink:MolecularActivity arachidonate-CoA ligase activity Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+. EC:6.2.1.15|KEGG_REACTION:R01598|MetaCyc:ARACHIDONATE--COA-LIGASE-RXN|RHEA:19713 go.json arachidonate:CoA ligase (AMP-forming)|arachidonoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0047676 GO:0047675 biolink:MolecularActivity arabinonate dehydratase activity Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O. EC:4.2.1.5|KEGG_REACTION:R03032|MetaCyc:ARABINONATE-DEHYDRATASE-RXN|RHEA:21836 go.json D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)|D-arabinonate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047675 GO:0047674 biolink:MolecularActivity apiose 1-reductase activity Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + H+ + NADH. EC:1.1.1.114|KEGG_REACTION:R03577|MetaCyc:APIOSE-1-REDUCTASE-RXN|RHEA:15301 go.json D-apiitol reductase activity|D-apiitol:NAD+ 1-oxidoreductase activity|D-apiose reductase activity http://purl.obolibrary.org/obo/GO_0047674 GO:0047673 biolink:MolecularActivity anthranilate N-malonyltransferase activity Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA. EC:2.3.1.113|KEGG_REACTION:R00989|MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN|RHEA:17557 go.json malonyl-CoA:anthranilate N-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0047673 GO:0141053 biolink:MolecularActivity histone H2A ubiquitin ligase activity Catalysis of the transfer of ubiquitin to a histone H2A substrate. go.json http://purl.obolibrary.org/obo/GO_0141053 GO:0141052 biolink:MolecularActivity histone H3 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. go.json http://purl.obolibrary.org/obo/GO_0141052 GO:0141055 biolink:MolecularActivity histone H3 ubiquitin ligase activity Catalysis of the transfer of ubiquitin to a histone H3 substrate. go.json http://purl.obolibrary.org/obo/GO_0141055 GO:0141054 biolink:MolecularActivity histone H2B ubiquitin ligase activity Catalysis of the transfer of ubiquitin to a histone H2B substrate. go.json http://purl.obolibrary.org/obo/GO_0141054 GO:0141057 biolink:MolecularActivity histone H3 arginine deiminase activity Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination. go.json http://purl.obolibrary.org/obo/GO_0141057 GO:0072639 biolink:BiologicalProcess interleukin-33 production The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json C9orf26 production|IL-33 production|IL1F11 production|IL33 production|NF-HEV production|interleukin-33 biosynthetic process|interleukin-33 secretion http://purl.obolibrary.org/obo/GO_0072639 gocheck_do_not_annotate GO:0141056 biolink:MolecularActivity histone H4 ubiquitin ligase activity Catalysis of the transfer of ubiquitin to a histone H4 substrate. go.json http://purl.obolibrary.org/obo/GO_0141056 GO:0141059 biolink:BiologicalProcess symbiont-mediated disruption of host antimicrobial peptide activity Any process in which a symbiont interferes with a host antimicrobial peptide, for example by cleavage or degredation. go.json disruption of host antimicrobial peptide activity http://purl.obolibrary.org/obo/GO_0141059 GO:0072638 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072638 GO:0072637 biolink:BiologicalProcess interleukin-32 production The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-32 production|IL32 production|NK4 production|TAIF production|interleukin-32 biosynthetic process|interleukin-32 secretion http://purl.obolibrary.org/obo/GO_0072637 gocheck_do_not_annotate GO:0141058 biolink:MolecularActivity histone H4 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. go.json http://purl.obolibrary.org/obo/GO_0141058 GO:0072636 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072636 GO:0072635 biolink:BiologicalProcess interleukin-31 production The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-31 production|interleukin-31 secretion http://purl.obolibrary.org/obo/GO_0072635 gocheck_do_not_annotate GO:0072634 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072634 GO:0072633 biolink:BiologicalProcess interleukin-30 production The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-30 production|interleukin-30 complex production|interleukin-30 secretion http://purl.obolibrary.org/obo/GO_0072633 gocheck_do_not_annotate GO:0072632 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072632 GO:0072631 biolink:BiologicalProcess interleukin-29 production The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-29 production|IL29 production|interferon lambda 1 production|interleukin-29 secretion http://purl.obolibrary.org/obo/GO_0072631 gocheck_do_not_annotate GO:0141051 biolink:MolecularActivity histone H4K deacetylase activity Catalysis of the reaction: histone H4 N6-acetyl-L-lysine + H2O = histone H4 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H4. go.json http://purl.obolibrary.org/obo/GO_0141051 GO:0072630 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072630 GO:0141050 biolink:MolecularActivity histone H3K deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3. go.json http://purl.obolibrary.org/obo/GO_0141050 GO:0047683 biolink:MolecularActivity aryl-aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP. EC:1.2.1.30|MetaCyc:1.2.1.30-RXN|RHEA:19229 go.json aromatic acid reductase activity|aryl-aldehyde:NADP+ oxidoreductase (ATP-forming) http://purl.obolibrary.org/obo/GO_0047683 GO:0047682 biolink:MolecularActivity aryl-alcohol oxidase activity Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2. EC:1.1.3.7|MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN|RHEA:17541 go.json arom. alcohol oxidase activity|aryl alcohol oxidase activity|aryl-alcohol:oxygen oxidoreductase activity|veratryl alcohol oxidase activity http://purl.obolibrary.org/obo/GO_0047682 GO:0047681 biolink:MolecularActivity aryl-alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH. EC:1.1.1.91|MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN|RHEA:17761 go.json NADPH-linked benzaldehyde reductase activity|aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)|aryl-alcohol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047681 GO:0047680 biolink:MolecularActivity aryl-acylamidase activity Catalysis of the reaction: anilide + H2O = a carboxylate + aniline + H+. EC:3.5.1.13|KEGG_REACTION:R01862|MetaCyc:ARYL-ACYLAMIDASE-RXN|RHEA:20297 go.json AAA-1|AAA-2|aryl-acylamide amidohydrolase activity|brain acetylcholinesterase (is associated with AAA-2)|pseudocholinesterase (associated with arylacylamidase) http://purl.obolibrary.org/obo/GO_0047680 GO:0141049 biolink:MolecularActivity protein-glutathione oxidoreductase (glutathione) activity Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism. go.json glutaredoxin activity|glutathione oxidoreductase activity http://purl.obolibrary.org/obo/GO_0141049 GO:0047689 biolink:MolecularActivity aspartate racemase activity Catalysis of the reaction: L-aspartate = D-aspartate. EC:5.1.1.13|KEGG_REACTION:R00491|MetaCyc:ASPARTATE-RACEMASE-RXN|RHEA:14973 go.json D-aspartate racemase activity http://purl.obolibrary.org/obo/GO_0047689 GO:0047688 biolink:MolecularActivity aspartate 4-decarboxylase activity Catalysis of the reaction: L-aspartate = L-alanine + CO2. EC:4.1.1.12|MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN|RHEA:12621 go.json L-aspartate 4-carboxy-lyase (L-alanine-forming)|L-aspartate 4-carboxy-lyase activity|L-aspartate beta-decarboxylase activity|L-cysteine sulfinate acid desulfinase activity|aminomalonic decarboxylase activity|aspartate beta-decarboxylase activity|aspartate omega-decarboxylase activity|aspartic beta-decarboxylase activity|aspartic omega-decarboxylase activity|cysteine sulfinic desulfinase activity|desulfinase activity http://purl.obolibrary.org/obo/GO_0047688 GO:0047687 biolink:MolecularActivity obsolete ascorbate 2,3-dioxygenase activity OBSOLETE. Catalysis of the reaction: L-ascorbate + H2O + O2 = L-threonate + 2 H+ + oxalate. KEGG_REACTION:R00646|MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN go.json AAoxygenase activity|ascorbate 2,3-dioxygenase activity|ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving) True http://purl.obolibrary.org/obo/GO_0047687 GO:0047686 biolink:MolecularActivity arylsulfate sulfotransferase activity Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate. EC:2.8.2.22|MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN|RHEA:51072 go.json ASST|arylsulfate-phenol sulfotransferase activity|arylsulfate:phenol sulfotransferase activity|arylsulfotransferase|arylsulphate sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047686 GO:0047685 biolink:MolecularActivity amine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate. EC:2.8.2.3|MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN|RHEA:24136 go.json 3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity|amine N-sulfotransferase activity|amine sulphotransferase activity|arylamine sulfotransferase activity http://purl.obolibrary.org/obo/GO_0047685 GO:0047684 biolink:MolecularActivity arylamine glucosyltransferase activity Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine. EC:2.4.1.71|MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN go.json UDP glucose-arylamine glucosyltransferase activity|UDP-glucose:arylamine N-D-glucosyltransferase activity|UDPglucose:arylamine N-D-glucosyltransferase activity|uridine diphosphoglucose-arylamine glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047684 GO:0141042 biolink:BiologicalProcess symbiont-mediated cAMP intoxication of host cell The production by a symbiont of high levels of cyclic AMP in a host cell, impairing host cellular functions in multiple ways, including ATP depletion, interference with host intracellular signaling, cytoskeletal defects and apoptosis-related cell death. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json cAMP intoxication in host http://purl.obolibrary.org/obo/GO_0141042 GO:0141041 biolink:BiologicalProcess disruption of extracellular matrix of another organism The chemical reactions and pathways performed by an organism resulting in the breakdown of the extracellular matrix of another organism. go.json http://purl.obolibrary.org/obo/GO_0141041 GO:0141044 biolink:BiologicalProcess epigenetic programming in the endosperm The global programming of epigenetic modifications following binucleate central cell fertilization. This involves DNA methylation at the silent allele. In the endosperm, maternal genomes are hypomethylated compared with the paternal genome. go.json epigenetic reprogramming in the endosperm http://purl.obolibrary.org/obo/GO_0141044 GO:0141043 biolink:BiologicalProcess evasion of host innate immune recognition A process by which a symbiont avoids recognition by host's innate immune response by altering a conserved molecule recognized by the host's cell surface and intracellular innate immune receptors, including Toll-like receptors, and NOD-like receptors. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141043 GO:0072629 biolink:BiologicalProcess interleukin-28B production The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-28B production|IL28B production|interferon lambda 3 production|interleukin-28B secretion http://purl.obolibrary.org/obo/GO_0072629 gocheck_do_not_annotate GO:0141046 biolink:MolecularActivity Atg8-family conjugating enzyme activity Isoenergetic transfer of an Atg8 family modifer from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X. go.json APG8 conjugating enzyme activity|Atg8 conjugating enzyme activity|Atg8-like conjugating activity|E2 http://purl.obolibrary.org/obo/GO_0141046 GO:0072628 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072628 GO:0072627 biolink:BiologicalProcess interleukin-28A production The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-28A production|IL28A production|interferon lambda 2 production|interleukin-28A secretion http://purl.obolibrary.org/obo/GO_0072627 gocheck_do_not_annotate GO:0141048 biolink:MolecularActivity membrane tag activity A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy. go.json covalent modifier|lipid tag http://purl.obolibrary.org/obo/GO_0141048 GO:0072626 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072626 GO:0141047 biolink:MolecularActivity molecular tag activity A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. go.json covalent modifier|tag http://purl.obolibrary.org/obo/GO_0141047 GO:0072625 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072625 GO:0072624 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072624 GO:0072623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072623 GO:0072622 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072622 GO:0072621 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072621 GO:0072620 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072620 GO:0141040 biolink:MolecularActivity very-long-chain 3-oxoacyl-CoA reductase activity Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. EC:1.1.1.330|MetaCyc:RXN-7698|RHEA:48680|Reactome:R-HSA-548818 go.json http://purl.obolibrary.org/obo/GO_0141040 GO:0072650 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072650 GO:0047694 biolink:MolecularActivity barbiturase activity Catalysis of the reaction: barbiturate + H2O = malonate + urea. EC:3.5.2.1|MetaCyc:BARBITURASE-RXN|RHEA:18653 go.json barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming) http://purl.obolibrary.org/obo/GO_0047694 GO:0047693 biolink:MolecularActivity ATP diphosphatase activity Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. EC:3.6.1.8|MetaCyc:ATP-PYROPHOSPHATASE-RXN|RHEA:14245 go.json ATP diphosphohydrolase|ATP diphosphohydrolase (diphosphate-forming)|ATP pyrophosphatase activity|adenosine triphosphate pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0047693 GO:0047692 biolink:MolecularActivity ATP deaminase activity Catalysis of the reaction: ATP + H2O = ITP + NH3. EC:3.5.4.18|MetaCyc:ATP-DEAMINASE-RXN|RHEA:13037 go.json ATP aminohydrolase activity|adenosine triphosphate deaminase activity http://purl.obolibrary.org/obo/GO_0047692 GO:0047691 biolink:MolecularActivity aspulvinone dimethylallyltransferase activity Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate. EC:2.5.1.35|KEGG_REACTION:R03799|MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN|RHEA:13809 go.json dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity|dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity http://purl.obolibrary.org/obo/GO_0047691 GO:0047690 biolink:MolecularActivity obsolete aspartyltransferase activity OBSOLETE. Catalysis of the reaction: L-asparagine + H+ + hydroxylamine = beta-L-aspartylhydroxamate + NH4. go.json L-asparagine:hydroxylamine gamma-aspartyltransferase activity|aspartotransferase activity|beta-aspartyl transferase activity True http://purl.obolibrary.org/obo/GO_0047690 GO:0047699 biolink:MolecularActivity beta-diketone hydrolase activity Catalysis of the reaction: H2O + nonane-4,6-dione = butanoate + H+ + pentan-2-one. EC:3.7.1.7|KEGG_REACTION:R03781|MetaCyc:BETA-DIKETONE-HYDROLASE-RXN|RHEA:11908 go.json b-diketone hydrolase activity|nonane-4,6-dione acylhydrolase activity|oxidized PVA hydrolase activity http://purl.obolibrary.org/obo/GO_0047699 GO:0047698 biolink:MolecularActivity beta-alanyl-CoA ammonia-lyase activity Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3. EC:4.3.1.6|MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN|RHEA:12416 go.json b-alanyl-CoA ammonia-lyase activity|beta-alanyl coenzyme A ammonia-lyase activity|beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming) http://purl.obolibrary.org/obo/GO_0047698 GO:0047697 biolink:MolecularActivity beta-alanopine dehydrogenase activity Catalysis of the reaction: (R)-beta-alanopine + H2O + NAD+ = beta-alanine + H+ + NADH + pyruvate. EC:1.5.1.26|KEGG_REACTION:R00906|MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN|RHEA:21684 go.json N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)|b-alanopine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047697 GO:0047696 biolink:MolecularActivity beta-adrenergic receptor kinase activity Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. EC:2.7.11.15|RHEA:19429|Reactome:R-HSA-8851797|Reactome:R-HSA-8866268 go.json ADRBK1|ATP:beta-adrenergic-receptor phosphotransferase activity|BARK1|GRK2|GRK3|STK15|[b-adrenergic-receptor] kinase activity|adrenergic receptor kinase activity|beta-AR kinase activity|beta-ARK|beta-ARK 1|beta-ARK 2|beta-adrenergic receptor-specific kinase activity|beta-adrenergic-receptor kinase (phosphorylating) activity|beta-adrenergic-receptor kinase activity|beta-adrenoceptor kinase 1 activity|beta-adrenoceptor kinase 2 activity|beta-adrenoceptor kinase activity|beta-receptor kinase activity|beta2ARK|betaARK1 http://purl.obolibrary.org/obo/GO_0047696 GO:0047695 biolink:MolecularActivity benzoin aldolase activity Catalysis of the reaction: benzoin = 2 benzaldehyde. EC:4.1.2.38|KEGG_REACTION:R00027|MetaCyc:BENZOIN-ALDOLASE-RXN|RHEA:21460 go.json 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity|2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)|2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity|benzaldehyde lyase activity|diphenylethanone benzaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0047695 GO:0072659 biolink:BiologicalProcess protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. go.json protein localisation in plasma membrane|protein localization in plasma membrane|protein targeting to plasma membrane|protein-plasma membrane targeting http://purl.obolibrary.org/obo/GO_0072659 goslim_generic|goslim_pombe GO:0072658 biolink:BiologicalProcess maintenance of protein location in membrane Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0072658 GO:0072657 biolink:BiologicalProcess protein localization to membrane A process in which a protein is transported to, or maintained in, a specific location in a membrane. go.json protein localisation in membrane|protein localization in membrane http://purl.obolibrary.org/obo/GO_0072657 prokaryote_subset GO:0072656 biolink:BiologicalProcess maintenance of protein location in mitochondrion Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0072656 GO:0072655 biolink:BiologicalProcess establishment of protein localization to mitochondrion The directed movement of a protein to the mitochondrion or a part of the mitochondrion. go.json establishment of protein localisation to mitochondrion|establishment of protein localization in mitochondrion http://purl.obolibrary.org/obo/GO_0072655 GO:0072654 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072654 GO:0072653 biolink:BiologicalProcess interferon-omega production The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-omega production|IFNW production|interferon-omega secretion http://purl.obolibrary.org/obo/GO_0072653 gocheck_do_not_annotate GO:0072652 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072652 GO:0072651 biolink:BiologicalProcess interferon-tau production The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-tau production|IFN-tau secretion|IFNT production|interferon-tau secretion http://purl.obolibrary.org/obo/GO_0072651 gocheck_do_not_annotate GO:0072649 biolink:BiologicalProcess interferon-kappa production The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-kappa production|IFNK production|interferon-kappa secretion http://purl.obolibrary.org/obo/GO_0072649 gocheck_do_not_annotate GO:0072648 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072648 GO:0072647 biolink:BiologicalProcess interferon-epsilon production The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-epsilon production|IFNE production|interferon-epsilon secretion http://purl.obolibrary.org/obo/GO_0072647 gocheck_do_not_annotate GO:0072646 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072646 GO:0072645 biolink:BiologicalProcess interferon-delta production The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-delta production|IFND production|interferon-delta secretion http://purl.obolibrary.org/obo/GO_0072645 gocheck_do_not_annotate GO:0072644 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072644 GO:0072643 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072643 GO:0072642 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072642 GO:0072641 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072641 GO:0072640 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072640 GO:0072672 biolink:BiologicalProcess neutrophil extravasation The migration of a neutrophil from the blood vessels into the surrounding tissue. go.json http://purl.obolibrary.org/obo/GO_0072672 GO:0072671 biolink:BiologicalProcess mitochondria-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions. go.json MAD|mitochondria-associated protein catabolic process|mitochondria-associated protein degradation|mitochondrion-associated protein catabolic process http://purl.obolibrary.org/obo/GO_0072671 GO:0072670 biolink:BiologicalProcess mitochondrial tRNA threonylcarbamoyladenosine modification The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base). go.json mitochondrial tRNA t6A modification http://purl.obolibrary.org/obo/GO_0072670 GO:0141017 biolink:BiologicalProcess effector-mediated induction of cell cycle reactivation in host A symbiont process in which a molecule secreted by the symbiont reactivates the host cell cycle, resulting in DNA synthesis and host cell division, and contributing to vegetative tumor formation. go.json http://purl.obolibrary.org/obo/GO_0141017 GO:0141016 biolink:MolecularActivity G/T mismatch-specific thymine-DNA glycosylase activity Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site. EC:3.2.2.29 go.json http://purl.obolibrary.org/obo/GO_0141016 GO:0141018 biolink:BiologicalProcess adhesion of symbiont to host via host extracellular matrix The attachment of a symbiont to its host by binding to a component of the host extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adhesion of symbiont to host extracellular matrix via collagen|adhesion of symbiont to host extracellular matrix via fibronectin|adhesion of symbiont to host extracellular matrix via integrin|adhesion of symbiont to host extracellular matrix via laminin|adhesion of symbiont to host extracellular matrix via vitronectin http://purl.obolibrary.org/obo/GO_0141018 GO:0141011 biolink:BiologicalProcess siRNA-mediated retrotransposon silencing by mRNA destabilization A retrotransposon silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a siRNA. go.json siRNA-mediated post-transcriptional retrotransposon silencing http://purl.obolibrary.org/obo/GO_0141011 GO:0141010 biolink:BiologicalProcess retrotransposon silencing by RNA-directed DNA methylation A retrotransposon silencing mechanism mediated by RNA-directed DNA methylation. RNA-directed DNA methylation is a gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. go.json retrostransposon silencing by RdDM http://purl.obolibrary.org/obo/GO_0141010 GO:0141013 biolink:BiologicalProcess purine nucleotide import into lysosome The directed import of purine nucleotide from the cytosol, across the lysosomal membrane, into the lysosome. go.json http://purl.obolibrary.org/obo/GO_0141013 GO:0141014 biolink:BiologicalProcess ribosome hibernation A cellular process that results in the silencing of ribosomes in quiescent cells. Quiescence takes place when cells encounter unfavorable conditions and cease to grow in bacteria and yeast. It also takes place in some specialized cells in higher eukaryotes, such as eggs. Ribosomes in a hibernation state are kept silent via association with proteins with inhibitory and protective functions. go.json http://purl.obolibrary.org/obo/GO_0141014 GO:0072679 biolink:BiologicalProcess thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development. go.json immature T cell migration|immature T lymphocyte migration|immature T-cell migration|immature T-lymphocyte migration|thymic lymphocyte migration http://purl.obolibrary.org/obo/GO_0072679 GO:0072678 biolink:BiologicalProcess T cell migration The movement of a T cell within or between different tissues and organs of the body. go.json T lymphocyte migration|T-cell migration|T-lymphocyte migration http://purl.obolibrary.org/obo/GO_0072678 GO:0072677 biolink:BiologicalProcess eosinophil migration The movement of an eosinophil within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0072677 GO:0072676 biolink:BiologicalProcess lymphocyte migration The movement of a lymphocyte within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0072676 GO:0072675 biolink:BiologicalProcess osteoclast fusion The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast. go.json http://purl.obolibrary.org/obo/GO_0072675 GO:0072674 biolink:BiologicalProcess multinuclear osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. go.json multinuclear osteoclast formation|multinuclear osteoclast morphogenesis http://purl.obolibrary.org/obo/GO_0072674 GO:0072673 biolink:BiologicalProcess lamellipodium morphogenesis A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized. go.json lamellipodium organization http://purl.obolibrary.org/obo/GO_0072673 GO:0072661 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072661 GO:0072660 biolink:BiologicalProcess maintenance of protein location in plasma membrane Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0072660 GO:0141006 biolink:BiologicalProcess piRNA-mediated retrotransposon silencing by heterochromatin formation A retrotransposon silencing mechanism in which a piRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. go.json http://purl.obolibrary.org/obo/GO_0141006 GO:0141005 biolink:BiologicalProcess retrotransposon silencing by heterochromatin formation A retrotransposon silencing mechanism involving heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. go.json http://purl.obolibrary.org/obo/GO_0141005 GO:0141008 biolink:BiologicalProcess retrotransposon silencing by mRNA destabilization A retrotransposon silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation. go.json post-transcriptional retrotransposon silencing http://purl.obolibrary.org/obo/GO_0141008 GO:0141007 biolink:BiologicalProcess siRNA-mediated retrotransposon silencing by heterochromatin formation A retrotransposon silencing mechanism in which a siRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. go.json http://purl.obolibrary.org/obo/GO_0141007 GO:0141009 biolink:BiologicalProcess piRNA-mediated retrotransposon silencing by mRNA destabilization A retrotransposon silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a piRNA. go.json piRNA-mediated post-transcriptional retrotransposon silencing http://purl.obolibrary.org/obo/GO_0141009 GO:0033097 biolink:CellularComponent amyloplast membrane Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope. go.json http://purl.obolibrary.org/obo/GO_0033097 GO:0033096 biolink:CellularComponent amyloplast envelope The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. go.json http://purl.obolibrary.org/obo/GO_0033096 GO:0141000 biolink:MolecularActivity histone H4K91 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue. go.json histone H4-K91 ubiquitin ligase activity|histone ubiquitin ligase activity (H4-K91 specific) http://purl.obolibrary.org/obo/GO_0141000 GO:0033095 biolink:CellularComponent aleurone grain A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes. go.json aleurone body http://purl.obolibrary.org/obo/GO_0033095 GO:0033094 biolink:MolecularActivity putrescine--2-oxoglutarate transaminase activity Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline. EC:2.6.1.82|MetaCyc:PUTTRANSAM-RXN|RHEA:12268 go.json PAT activity|YgjG|butane-1,4-diamine:2-oxoglutarate aminotransferase activity|putrescine aminotransferase activity|putrescine transaminase activity|putrescine-alpha-ketoglutarate transaminase activity|putrescine:2-oxoglutarate aminotransferase activity|putrescine:alpha-ketoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0033094 GO:0141002 biolink:MolecularActivity histone H4K16 propionyltransferase activity Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16). go.json http://purl.obolibrary.org/obo/GO_0141002 GO:0033093 biolink:CellularComponent Weibel-Palade body A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. Wikipedia:Weibel-Palade_body go.json http://purl.obolibrary.org/obo/GO_0033093 GO:0033092 biolink:BiologicalProcess positive regulation of immature T cell proliferation in thymus Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus. go.json positive regulation of thymic T cell proliferation|positive regulation of thymocyte cell proliferation|positive regulation of thymocyte proliferation http://purl.obolibrary.org/obo/GO_0033092 GO:0033091 biolink:BiologicalProcess positive regulation of immature T cell proliferation Any process that activates or increases the frequency, rate or extent of immature T cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0033091 GO:0141003 biolink:MolecularActivity histone H2AX kinase activity Catalysis of the transfer of a phosphate group to a histone variant H2AX. go.json http://purl.obolibrary.org/obo/GO_0141003 GO:0033090 biolink:BiologicalProcess positive regulation of extrathymic T cell differentiation Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation. go.json positive regulation of extrathymic T cell development http://purl.obolibrary.org/obo/GO_0033090 GO:0072669 biolink:CellularComponent tRNA-splicing ligase complex A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. MetaCyc:ENTMULTI-CPLX go.json tRNA splicing ligase complex http://purl.obolibrary.org/obo/GO_0072669 GO:0072668 biolink:BiologicalProcess obsolete tubulin complex biogenesis OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled. go.json tubulin complex biogenesis True http://purl.obolibrary.org/obo/GO_0072668 GO:0072667 biolink:BiologicalProcess maintenance of protein location in vacuole Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0072667 GO:0072666 biolink:BiologicalProcess establishment of protein localization to vacuole The directed movement of a protein to a specific location in a vacuole. go.json establishment of protein localisation to vacuole http://purl.obolibrary.org/obo/GO_0072666 GO:0072665 biolink:BiologicalProcess protein localization to vacuole A process in which a protein is transported to, or maintained at, a location in a vacuole. go.json protein localisation to vacuole http://purl.obolibrary.org/obo/GO_0072665 GO:0072664 biolink:BiologicalProcess maintenance of protein location in peroxisome Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0072664 GO:0072663 biolink:BiologicalProcess establishment of protein localization to peroxisome The directed movement of a protein to a specific location in a peroxisome. go.json establishment of protein localisation to peroxisome http://purl.obolibrary.org/obo/GO_0072663 GO:0033099 biolink:CellularComponent attachment organelle A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division. go.json http://purl.obolibrary.org/obo/GO_0033099 goslim_pir GO:0072662 biolink:BiologicalProcess protein localization to peroxisome A process in which a protein is transported to, or maintained at, a location in a peroxisome. go.json protein localisation to peroxisome http://purl.obolibrary.org/obo/GO_0072662 GO:0033098 biolink:CellularComponent amyloplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma. go.json http://purl.obolibrary.org/obo/GO_0033098 GO:0008209 biolink:BiologicalProcess androgen metabolic process The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. go.json androgen metabolism http://purl.obolibrary.org/obo/GO_0008209 GO:0008208 biolink:BiologicalProcess C21-steroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. go.json C21-steroid hormone breakdown|C21-steroid hormone catabolism|C21-steroid hormone degradation http://purl.obolibrary.org/obo/GO_0008208 GO:0008207 biolink:BiologicalProcess C21-steroid hormone metabolic process The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. go.json C21-steroid hormone metabolism http://purl.obolibrary.org/obo/GO_0008207 GO:0008206 biolink:BiologicalProcess bile acid metabolic process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. go.json bile acid metabolism http://purl.obolibrary.org/obo/GO_0008206 GO:0008205 biolink:BiologicalProcess ecdysone metabolic process The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development. go.json ecdysone metabolism http://purl.obolibrary.org/obo/GO_0008205 GO:0047812 biolink:MolecularActivity D-amino-acid N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid. EC:2.3.1.36|MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN|RHEA:20704 go.json D-amino acid acetyltransferase activity|D-amino acid-alpha-N-acetyltransferase activity|acetyl-CoA:D-amino-acid N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047812 GO:0008204 biolink:BiologicalProcess ergosterol metabolic process The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light. go.json ergosterol metabolism http://purl.obolibrary.org/obo/GO_0008204 GO:0008203 biolink:BiologicalProcess cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. go.json cholesterol metabolism http://purl.obolibrary.org/obo/GO_0008203 GO:0047811 biolink:MolecularActivity D-alanine gamma-glutamyltransferase activity Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4. EC:2.3.2.14|KEGG_REACTION:R01149|MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN|RHEA:23556 go.json D-alanine g-glutamyltransferase activity http://purl.obolibrary.org/obo/GO_0047811 GO:0047810 biolink:MolecularActivity D-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate. EC:2.6.1.21|MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN|RHEA:15869 go.json D-alanine aminotransferase activity|D-alanine transaminase activity|D-alanine-D-glutamate transaminase activity|D-amino acid aminotransferase activity|D-amino acid transaminase activity|D-amino-acid transaminase activity|D-aspartate aminotransferase activity|D-aspartate transaminase activity|D-aspartic aminotransferase activity http://purl.obolibrary.org/obo/GO_0047810 GO:0008202 biolink:BiologicalProcess steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. Wikipedia:Steroid_metabolism go.json steroid metabolism http://purl.obolibrary.org/obo/GO_0008202 GO:0008201 biolink:MolecularActivity heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. go.json heparan sulfate binding http://purl.obolibrary.org/obo/GO_0008201 GO:0008200 biolink:MolecularActivity ion channel inhibitor activity Binds to and stops, prevents, or reduces the activity of an ion channel. go.json http://purl.obolibrary.org/obo/GO_0008200 GO:0047819 biolink:MolecularActivity D-glutamate(D-aspartate) oxidase activity Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2. EC:1.4.3.15|MetaCyc:D-ASPARTATE-OXIDASE-RXN|MetaCyc:D-GLUTAMATE-OXIDASE-RXN go.json D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)|D-glutamic-aspartic oxidase activity|D-monoaminodicarboxylic acid oxidase activity http://purl.obolibrary.org/obo/GO_0047819 GO:0047818 biolink:MolecularActivity D-fuconate dehydratase activity Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O. EC:4.2.1.67|KEGG_REACTION:R03671|MetaCyc:D-FUCONATE-HYDRATASE-RXN|RHEA:12949 go.json D-fuconate hydratase activity|D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)|D-fuconate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047818 GO:0047817 biolink:MolecularActivity D-arginase activity Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea. EC:3.5.3.10|KEGG_REACTION:R02458|MetaCyc:D-ARGINASE-RXN|RHEA:12901 go.json D-arginine amidinohydrolase activity http://purl.obolibrary.org/obo/GO_0047817 GO:0047816 biolink:MolecularActivity D-arabinose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH. EC:1.1.1.116|MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN|RHEA:20457 go.json D-arabinose:NAD+ 1-oxidoreductase activity|NAD-pentose-dehydrogenase activity|arabinose(fucose)dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047816 GO:0047815 biolink:MolecularActivity D-arabinonolactonase activity Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate + H+. EC:3.1.1.30|KEGG_REACTION:R02714|MetaCyc:D-ARABINONOLACTONASE-RXN|RHEA:23108 go.json D-arabinono-1,4-lactone lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0047815 GO:0047814 biolink:MolecularActivity D-arabinokinase activity Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP. EC:2.7.1.54|KEGG_REACTION:R01573|MetaCyc:D-ARABINOKINASE-RXN|RHEA:24588 go.json ATP:D-arabinose 5-phosphotransferase activity|D-arabinokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0047814 GO:0047813 biolink:MolecularActivity D-arabinitol 4-dehydrogenase activity Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH. EC:1.1.1.11|MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN|RHEA:17921 go.json http://purl.obolibrary.org/obo/GO_0047813 GO:0008219 biolink:BiologicalProcess cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). go.json accidental cell death|necrosis http://purl.obolibrary.org/obo/GO_0008219 gocheck_do_not_annotate GO:0008218 biolink:BiologicalProcess bioluminescence The production of light by certain enzyme-catalyzed reactions in cells. Wikipedia:Bioluminescence go.json http://purl.obolibrary.org/obo/GO_0008218 goslim_chembl|goslim_metagenomics GO:0008217 biolink:BiologicalProcess regulation of blood pressure Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. Wikipedia:Blood_pressure#Regulation go.json blood pressure homeostasis|blood pressure regulation|control of blood pressure http://purl.obolibrary.org/obo/GO_0008217 GO:0008216 biolink:BiologicalProcess spermidine metabolic process The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. go.json spermidine metabolism http://purl.obolibrary.org/obo/GO_0008216 GO:0008215 biolink:BiologicalProcess spermine metabolic process The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. go.json spermine metabolism http://purl.obolibrary.org/obo/GO_0008215 GO:0047823 biolink:MolecularActivity D-glutamyltransferase activity Catalysis of the reaction: D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain. EC:2.3.2.1|MetaCyc:D-GLUTAMYLTRANSFERASE-RXN|RHEA:35623 go.json D-gamma-glutamyl transpeptidase activity|D-glutamyl transpeptidase activity|glutamine:D-glutamyl-peptide 5-glutamyltransferase activity http://purl.obolibrary.org/obo/GO_0047823 GO:0008214 biolink:BiologicalProcess protein dealkylation The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. go.json protein amino acid dealkylation http://purl.obolibrary.org/obo/GO_0008214 gocheck_do_not_annotate GO:0047822 biolink:MolecularActivity hypotaurine dehydrogenase activity Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine. EC:1.14.13.8|MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN|RHEA:69819|Reactome:R-HSA-1655453 go.json http://purl.obolibrary.org/obo/GO_0047822 GO:0008213 biolink:BiologicalProcess protein alkylation The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. go.json protein amino acid alkylation http://purl.obolibrary.org/obo/GO_0008213 gocheck_do_not_annotate|goslim_yeast GO:0047821 biolink:MolecularActivity D-glutamate oxidase activity Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2. EC:1.4.3.7|KEGG_REACTION:R00279|MetaCyc:D-GLUTAMATE-OXIDASE-RXN|RHEA:10028 go.json D-glutamate:oxygen oxidoreductase (deaminating)|D-glutamic acid oxidase activity|D-glutamic oxidase activity http://purl.obolibrary.org/obo/GO_0047821 GO:0008212 biolink:BiologicalProcess mineralocorticoid metabolic process The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. go.json mineralocorticoid metabolism http://purl.obolibrary.org/obo/GO_0008212 GO:0047820 biolink:MolecularActivity D-glutamate cyclase activity Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O. EC:4.2.1.48|KEGG_REACTION:R01583|MetaCyc:D-GLUTAMATE-CYCLASE-RXN|RHEA:22360 go.json D-glutamate hydro-lyase (cyclizing)|D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming) http://purl.obolibrary.org/obo/GO_0047820 GO:0008211 biolink:BiologicalProcess glucocorticoid metabolic process The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. go.json glucocorticoid metabolism|glucocorticosteroid metabolic process|glucocorticosteroid metabolism http://purl.obolibrary.org/obo/GO_0008211 GO:0008210 biolink:BiologicalProcess estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. go.json estrogen metabolism|oestrogen metabolic process|oestrogen metabolism http://purl.obolibrary.org/obo/GO_0008210 GO:0047829 biolink:MolecularActivity D-nopaline dehydrogenase activity Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH. EC:1.5.1.19|MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN|RHEA:19637 go.json 2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)|D-nopaline synthase activity|N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)|NOS activity|nopaline dehydrogenase activity|nopaline synthase activity http://purl.obolibrary.org/obo/GO_0047829 GO:0047828 biolink:MolecularActivity D-lyxose ketol-isomerase activity Catalysis of the reaction: D-lyxose = D-xylulose. EC:5.3.1.15|KEGG_REACTION:R01898|MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN|RHEA:14201 go.json D-lyxose aldose-ketose-isomerase activity|D-lyxose isomerase activity http://purl.obolibrary.org/obo/GO_0047828 GO:0047827 biolink:MolecularActivity D-lysopine dehydrogenase activity Catalysis of the reaction: D-lysopine + H2O + NADP+ = L-lysine + H+ + NADPH + pyruvate. EC:1.5.1.16|KEGG_REACTION:R00452|MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN|RHEA:17625 go.json 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|D(+)-lysopine dehydrogenase activity|D-lysopine synthase activity|N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|lysopine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047827 GO:0047826 biolink:MolecularActivity D-lysine 5,6-aminomutase activity Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate. EC:5.4.3.4|KEGG_REACTION:R02852|MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN|RHEA:18241 go.json D-2,6-diaminohexanoate 5,6-aminomutase activity|D-alpha-lysine mutase activity|adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity http://purl.obolibrary.org/obo/GO_0047826 GO:0047825 biolink:MolecularActivity D-lactate-2-sulfatase activity Catalysis of the reaction: (R)-2-O-sulfolactate + H2O = (R)-lactate + H+ + sulfate. EC:3.1.6.17|KEGG_REACTION:R01448|MetaCyc:D-LACTATE-2-SULFATASE-RXN|RHEA:20337 go.json (S)-2-O-sulfolactate 2-sulfohydrolase activity|D-lactate-2-sulphatase activity http://purl.obolibrary.org/obo/GO_0047825 GO:0047824 biolink:MolecularActivity D-iditol 2-dehydrogenase activity Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH. EC:1.1.1.15|MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN|RHEA:12725 go.json http://purl.obolibrary.org/obo/GO_0047824 GO:0047834 biolink:MolecularActivity D-threo-aldose 1-dehydrogenase activity Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH. EC:1.1.1.122|MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN|RHEA:19645 go.json (2S,3R)-aldose dehydrogenase activity|D-threo-aldose:NAD+ 1-oxidoreductase activity|L-fucose (D-arabinose) dehydrogenase activity|L-fucose dehydrogenase activity|dehydrogenase, L-fucose http://purl.obolibrary.org/obo/GO_0047834 GO:0047833 biolink:MolecularActivity D-sorbitol dehydrogenase (acceptor) activity Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. EC:1.1.99.21|MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN|RHEA:21320 go.json D-sorbitol dehydrogenase activity|D-sorbitol:(acceptor) 1-oxidoreductase activity|D-sorbitol:acceptor 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047833 GO:0047832 biolink:MolecularActivity D-pinitol dehydrogenase activity Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADPH. EC:1.1.1.142|KEGG_REACTION:R03498|MetaCyc:D-PINITOL-DEHYDROGENASE-RXN|RHEA:20437 go.json 1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity|5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047832 GO:0047831 biolink:MolecularActivity D-ornithine 4,5-aminomutase activity Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate. EC:5.4.3.5|KEGG_REACTION:R02461|MetaCyc:ORNMUTST-RXN|RHEA:14893 go.json D-alpha-ornithine 5,4-aminomutase activity|D-ornithine aminomutase activity http://purl.obolibrary.org/obo/GO_0047831 GO:0047830 biolink:MolecularActivity D-octopine dehydrogenase activity Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH. EC:1.5.1.11|MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN|RHEA:16285 go.json 2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)|D-octopine synthase activity|N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)|ODH activity|octopine dehydrogenase activity|octopine:NAD oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047830 GO:0047839 biolink:MolecularActivity dATP(dGTP)-DNA purinetransferase activity Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA. EC:2.6.99.1|MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN go.json dATP(dGTP)--DNA purine transferase activity|dATP(dGTP):depurinated-DNA purine transferase activity http://purl.obolibrary.org/obo/GO_0047839 GO:0047838 biolink:MolecularActivity D-xylose 1-dehydrogenase (NAD) activity Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH. EC:1.1.1.175|MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN|RHEA:13861 go.json (NAD)-linked D-xylose dehydrogenase activity|D-xylose dehydrogenase activity|D-xylose:NAD+ 1-oxidoreductase activity|NAD-D-xylose|NAD-D-xylose dehydrogenase activity|NAD-linked D-xylose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047838 GO:0047837 biolink:MolecularActivity D-xylose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH. EC:1.1.1.179|KEGG_REACTION:R01430|MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:22000 go.json D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|D-xylose-NADP dehydrogenase activity|D-xylose:NADP+ 1-oxidoreductase activity|D-xylose:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047837 GO:0047836 biolink:MolecularActivity D-tryptophan N-malonyltransferase activity Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H+. EC:2.3.1.112|KEGG_REACTION:R02482|MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN|RHEA:23320 go.json malonyl-CoA:D-tryptophan N-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0047836 GO:0047835 biolink:MolecularActivity D-tryptophan N-acetyltransferase activity Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+. EC:2.3.1.34|KEGG_REACTION:R02481|MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN|RHEA:10060 go.json D-tryptophan acetyltransferase activity|acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity|acetyl-CoA:D-tryptophan N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047835 GO:0047845 biolink:MolecularActivity deoxylimonate A-ring-lactonase activity Catalysis of the reaction: deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H+. EC:3.1.1.46|KEGG_REACTION:R03803|MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN|RHEA:14997 go.json deoxylimonate A-ring-lactonohydrolase activity http://purl.obolibrary.org/obo/GO_0047845 GO:0047844 biolink:MolecularActivity deoxycytidine deaminase activity Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3. EC:3.5.4.14|MetaCyc:CYTIDEAM-RXN|RHEA:13433 go.json deoxycytidine aminohydrolase activity http://purl.obolibrary.org/obo/GO_0047844 GO:0047843 biolink:MolecularActivity dehydrogluconate dehydrogenase activity Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2). EC:1.1.99.4|KEGG_REACTION:R07153|MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN|RHEA:12368 go.json 2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity|2-keto-D-gluconate dehydrogenase activity|2-oxogluconate dehydrogenase activity|alpha-ketogluconate dehydrogenase activity|ketogluconate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047843 GO:0047842 biolink:MolecularActivity dehydro-L-gulonate decarboxylase activity Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2. EC:4.1.1.34|KEGG_REACTION:R01905|MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN|RHEA:11084|Reactome:R-HSA-5662473 go.json 3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)|3-dehydro-L-gulonate carboxy-lyase activity|3-keto-L-gulonate decarboxylase activity|keto-L-gulonate decarboxylase activity http://purl.obolibrary.org/obo/GO_0047842 GO:0047841 biolink:MolecularActivity dehydrogluconokinase activity Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H+. EC:2.7.1.13|KEGG_REACTION:R02658|MetaCyc:DEHYDOGLUCONOKINASE-RXN|RHEA:10788 go.json 2-ketogluconate kinase activity|2-ketogluconokinase activity|ATP:2-dehydro-D-gluconate 6-phosphotransferase activity|dehydogluconokinase activity|ketogluconokinase (phosphorylating)|ketogluconokinase activity http://purl.obolibrary.org/obo/GO_0047841 GO:0047840 biolink:MolecularActivity dCTP diphosphatase activity Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate. EC:3.6.1.12|MetaCyc:DCTP-PYROPHOSPHATASE-RXN|RHEA:22636|Reactome:R-HSA-6786257 go.json dCTP nucleotidohydrolase activity|dCTP pyrophosphatase activity|dCTPase activity|deoxy-CTPase activity|deoxycytidine triphosphatase activity|deoxycytidine-triphosphatase activity http://purl.obolibrary.org/obo/GO_0047840 GO:0047849 biolink:MolecularActivity dextransucrase activity Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1). EC:2.4.1.5|MetaCyc:2.4.1.125-RXN go.json CEP|SGE|sucrose 6-glucosyltransferase activity|sucrose-1,6-alpha-glucan glucosyltransferase activity|sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047849 GO:0047848 biolink:MolecularActivity dephospho-[reductase kinase] kinase activity Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]. EC:2.7.11.3|MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN go.json AMP-activated kinase activity|AMP-activated protein kinase kinase activity|ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity|STK30|dephospho-reductase kinase kinase activity|hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity|hydroxymethylglutaryl coenzyme A reductase kinase kinase activity|reductase kinase activity|reductase kinase kinase activity http://purl.obolibrary.org/obo/GO_0047848 GO:0047847 biolink:MolecularActivity deoxyuridine phosphorylase activity Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate. EC:2.4.2.23|MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN|RHEA:22824 go.json 2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity|deoxyuridine:phosphate deoxy-D-ribosyltransferase activity|deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0047847 GO:0047846 biolink:MolecularActivity deoxynucleotide 3'-phosphatase activity Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate. EC:3.1.3.34|MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN|RHEA:10092 go.json 3'-deoxynucleotidase activity|3'-deoxyribonucleotidase activity|deoxyribonucleotide 3'-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047846 GO:0047856 biolink:MolecularActivity dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+. EC:3.1.1.35|KEGG_REACTION:R03692|MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN|RHEA:10360 go.json dihydrocoumarin lactonohydrolase activity|dihydrocoumarin lipase activity http://purl.obolibrary.org/obo/GO_0047856 GO:0047855 biolink:MolecularActivity dihydrobunolol dehydrogenase activity Catalysis of the reaction: dihydrobunolol + NADP+ = bunolol + H+ + NADPH. EC:1.1.1.160|KEGG_REACTION:R04623|MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN|RHEA:15925 go.json (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity|bunolol reductase activity http://purl.obolibrary.org/obo/GO_0047855 GO:0047854 biolink:MolecularActivity diguanidinobutanase activity Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea. EC:3.5.3.20|KEGG_REACTION:R01418|MetaCyc:DIGUANIDINOBUTANASE-RXN|RHEA:13597 go.json 1,4-diguanidinobutane amidinohydrolase activity http://purl.obolibrary.org/obo/GO_0047854 GO:0047853 biolink:MolecularActivity difructose-anhydride synthase activity Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose. EC:4.2.1.179|MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN|RHEA:15041 go.json bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity|inulobiose hydrolase activity http://purl.obolibrary.org/obo/GO_0047853 GO:0047852 biolink:MolecularActivity diferric-transferrin reductase activity Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH. EC:1.16.1.2|MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN|RHEA:13841 go.json NADH diferric transferrin reductase activity|diferric transferrin reductase activity|transferrin reductase activity|transferrin[Fe(II)]2:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047852 GO:0047851 biolink:MolecularActivity dicarboxylate-CoA ligase activity Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA. EC:6.2.1.23|MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN|RHEA:14289 go.json carboxylyl-CoA synthetase activity|omega-dicarboxylate:CoA ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0047851 GO:0047850 biolink:MolecularActivity diaminopimelate dehydrogenase activity Catalysis of the reaction: meso-2,6-diaminopimelate + H2O + NADP+ = L-2-amino-6-oxopimelate + H+ + NADPH + NH4. EC:1.4.1.16|KEGG_REACTION:R02755|MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN|RHEA:13561 go.json meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)|meso-alpha,epsilon-diaminopimelate dehydrogenase activity|meso-diaminopimelate D-dehydrogenase activity|meso-diaminopimelate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047850 GO:0047859 biolink:MolecularActivity obsolete dihydroxyphenylalanine ammonia-lyase activity OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3. EC:4.3.1.11 go.json 3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)|3,4-dihydroxy-L-phenylalanine ammonia-lyase activity|beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity|dihydroxyphenylalanine ammonia-lyase activity True http://purl.obolibrary.org/obo/GO_0047859 GO:0047858 biolink:MolecularActivity dihydroxyfumarate decarboxylase activity Catalysis of the reaction: dihydroxyfumarate + H+ = 2-hydroxy-3-oxopropanoate + CO2. EC:4.1.1.54|KEGG_REACTION:R03127|MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN|RHEA:13845 go.json dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)|dihydroxyfumarate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047858 GO:0047857 biolink:MolecularActivity dihydrouracil oxidase activity Catalysis of the reaction: 5,6-dihydrouracil + O2 = H2O2 + uracil. EC:1.3.3.7|KEGG_REACTION:R00975|MetaCyc:DIHYDROURACIL-OXIDASE-RXN|RHEA:12384 go.json 5,6-dihydrouracil:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047857 GO:0047867 biolink:MolecularActivity dimethylmalate dehydrogenase activity Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH. EC:1.1.1.84|KEGG_REACTION:R01211|MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN|RHEA:13321 go.json (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)|beta,beta-dimethylmalate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047867 GO:0047866 biolink:MolecularActivity dimethylglycine oxidase activity Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine. EC:1.5.3.10|KEGG_REACTION:R01564|MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN|RHEA:17077 go.json N,N-dimethylglycine:oxygen oxidoreductase (demethylating) http://purl.obolibrary.org/obo/GO_0047866 GO:0047865 biolink:MolecularActivity dimethylglycine dehydrogenase activity Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. EC:1.5.8.4|KEGG_REACTION:R01565|MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN|RHEA:52856|Reactome:R-HSA-6797653 go.json N,N-dimethylglycine oxidase activity|N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)|N,N-dimethylglycine:acceptor oxidoreductase (demethylating) http://purl.obolibrary.org/obo/GO_0047865 GO:0047864 biolink:MolecularActivity dimethylaniline-N-oxide aldolase activity Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde. EC:4.1.2.24|KEGG_REACTION:R03345|MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN|RHEA:19321 go.json N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)|N,N-dimethylaniline-N-oxide formaldehyde-lyase activity|microsomal N-oxide dealkylase activity|microsomal oxidase II http://purl.obolibrary.org/obo/GO_0047864 GO:0047863 biolink:MolecularActivity dimethylallylcistransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate. EC:2.5.1.28|KEGG_REACTION:R01659|MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN|RHEA:11328 go.json dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity|neryl-diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0047863 GO:0047862 biolink:MolecularActivity diisopropyl-fluorophosphatase activity Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + 2 H+ + hydrogen fluoride. EC:3.1.8.2|KEGG_REACTION:R01533|MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN|RHEA:24100 go.json DFPase activity|OPA anhydrase activity|OPAA activity|dialkylfluorophosphatase activity|diisopropyl phosphorofluoridate hydrolase activity|diisopropyl-fluorophosphate fluorohydrolase activity|diisopropylfluorophosphonate dehalogenase activity|diisopropylphosphofluoridase activity|isopropylphosphorofluoridase activity|organophosphate acid anhydrase activity|organophosphorus acid anhydrolase activity|somanase activity|tabunase activity http://purl.obolibrary.org/obo/GO_0047862 GO:0047861 biolink:MolecularActivity diiodotyrosine transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate. EC:2.6.1.24|KEGG_REACTION:R03207|MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN|RHEA:19781 go.json 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity|diiodotyrosine aminotransferase activity|halogenated tyrosine aminotransferase activity|halogenated tyrosine transaminase activity http://purl.obolibrary.org/obo/GO_0047861 GO:0047860 biolink:MolecularActivity diiodophenylpyruvate reductase activity Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH. EC:1.1.1.96|KEGG_REACTION:R03431|MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN|RHEA:20293 go.json 2-oxo acid reductase activity|3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity|KAR|aromatic alpha-keto acid http://purl.obolibrary.org/obo/GO_0047860 GO:0047869 biolink:MolecularActivity dimethylpropiothetin dethiomethylase activity Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H+. EC:4.4.1.3|KEGG_REACTION:R02574|MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN|RHEA:19965 go.json S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)|S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity|desulfhydrase activity http://purl.obolibrary.org/obo/GO_0047869 GO:0047868 biolink:MolecularActivity dimethylmaleate hydratase activity Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O. EC:4.2.1.85|KEGG_REACTION:R03069|MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN|RHEA:20253 go.json (2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)|(2R,3S)-2,3-dimethylmalate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047868 GO:0047870 biolink:MolecularActivity discadenine synthase activity Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H+. EC:2.5.1.24|KEGG_REACTION:R03726|MetaCyc:DISCADENINE-SYNTHASE-RXN|RHEA:19581 go.json S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity|S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas|discadenine synthetase activity http://purl.obolibrary.org/obo/GO_0047870 GO:0047878 biolink:MolecularActivity erythritol kinase activity Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H+. EC:2.7.1.27|KEGG_REACTION:R02430|MetaCyc:ERYTHRITOL-KINASE-RXN|RHEA:20708 go.json ATP:erythritol 4-phosphotransferase activity|erythritol kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0047878 GO:0047877 biolink:MolecularActivity ephedrine dehydrogenase activity Catalysis of the reaction: (1R,2S)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H+ + NADH. EC:1.5.1.18|KEGG_REACTION:R03614|MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN|RHEA:16289 go.json (-)-ephedrine:NAD+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047877 GO:0047876 biolink:MolecularActivity endoglycosylceramidase activity Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose. EC:3.2.1.123|MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN|RHEA:22288 go.json EGCase activity|endo-glucosylceramidase activity|endoglycoceramidase activity|glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity|oligoglycosylglucosylceramide glycohydrolase activity http://purl.obolibrary.org/obo/GO_0047876 GO:0047875 biolink:MolecularActivity ecdysone oxidase activity Catalysis of the reaction: Ecdysone + O2 = 3-dehydroecdysone + H2O2. EC:1.1.3.16|KEGG_REACTION:R02373|MetaCyc:ECDYSONE-OXIDASE-RXN|RHEA:11796 go.json beta-ecdysone oxidase activity|ecdysone:oxygen 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047875 GO:0047874 biolink:MolecularActivity dolichyldiphosphatase activity Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. EC:3.6.1.43|MetaCyc:DOLICHYLDIPHOSPHATASE-RXN|RHEA:14385|Reactome:R-HSA-446200 go.json dolichol diphosphatase activity|dolichyl diphosphate phosphohydrolase activity|dolichyl pyrophosphatase activity|dolichyl-diphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047874 GO:0047873 biolink:MolecularActivity dolichyl-phosphatase activity Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate. EC:3.1.3.51|MetaCyc:DOLICHYL-PHOSPHATASE-RXN|RHEA:13797 go.json Dol-P phosphatase activity|Dol-P-P phosphohydrolase activity|dolichol monophosphatase activity|dolichol phosphatase activity|dolichol phosphate phosphatase activity|dolichyl monophosphate phosphatase activity|dolichyl phosphate phosphatase activity|dolichyl pyrophosphate phosphatase activity|dolichyl-phosphate phosphohydrolase activity|polyisoprenyl phosphate phosphatase activity|polyprenylphosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0047873 GO:0047872 biolink:MolecularActivity dolichol O-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate. EC:2.3.1.123|MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN|RHEA:16685 go.json acyl-CoA:dolichol acyltransferase activity|palmitoyl-CoA:dolichol O-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0047872 GO:0047871 biolink:MolecularActivity disulfoglucosamine-6-sulfatase activity Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + H+ + sulfate. EC:3.1.6.11|KEGG_REACTION:R03216|MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN|RHEA:15517 go.json 6,N-disulfoglucosamine 6-O-sulfohydrolase activity|N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity|N-sulfoglucosamine-6-sulfatase activity|disulphoglucosamine-6-sulphatase activity http://purl.obolibrary.org/obo/GO_0047871 GO:0047879 biolink:MolecularActivity erythronolide synthase activity Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B. EC:2.3.1.94|MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN|RHEA:23068 go.json erythronolide condensing enzyme activity|malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing) http://purl.obolibrary.org/obo/GO_0047879 GO:0047881 biolink:MolecularActivity estradiol 17-alpha-dehydrogenase activity Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+. EC:1.1.1.148|MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN go.json 17alpha-estradiol dehydrogenase activity|17alpha-hydroxy steroid dehydrogenase activity|17alpha-hydroxy steroid oxidoreductase activity|17alpha-hydroxysteroid oxidoreductase activity|17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity|estradiol 17a-dehydrogenase activity|estradiol 17alpha-dehydrogenase activity|estradiol 17alpha-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047881 GO:0047880 biolink:MolecularActivity erythrulose reductase activity Catalysis of the reaction: D-threitol + NADP+ = D-erythrulose + H+ + NADPH. EC:1.1.1.162|KEGG_REACTION:R08573|MetaCyc:ERYTHRULOSE-REDUCTASE-RXN|RHEA:18005 go.json D-erythrulose reductase activity|erythritol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047880 GO:0047889 biolink:MolecularActivity ferredoxin-nitrate reductase activity Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin. EC:1.7.7.2|MetaCyc:1.7.7.2-RXN|RHEA:21828 go.json assimilatory ferredoxin-nitrate reductase activity|assimilatory nitrate reductase activity|nitrate (ferredoxin) reductase activity|nitrite:ferredoxin oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047889 GO:0047888 biolink:MolecularActivity fatty acid peroxidase activity Catalysis of the reaction: 2 H2O2 + H+ + palmitate = CO2 + 3 H2O + pentadecanal. EC:1.11.1.3|KEGG_REACTION:R01703|MetaCyc:FATTY-ACID-PEROXIDASE-RXN|RHEA:23960 go.json fatty-acid peroxidase activity|hexadecanoate:hydrogen-peroxide oxidoreductase activity|long chain fatty acid peroxidase activity http://purl.obolibrary.org/obo/GO_0047888 GO:0047887 biolink:MolecularActivity farnesyl diphosphate kinase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP. EC:2.7.4.18|KEGG_REACTION:R02303|MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN|RHEA:21544 go.json ATP:farnesyl-diphosphate phosphotransferase activity|farnesyl pyrophosphate kinase activity|farnesyl-diphosphate kinase activity http://purl.obolibrary.org/obo/GO_0047887 GO:0047886 biolink:MolecularActivity farnesol dehydrogenase activity Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + H+ + NADPH. EC:1.1.1.216|KEGG_REACTION:R03264|MetaCyc:FARNESOL-DEHYDROGENASE-RXN|RHEA:14697 go.json 2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity|NADP-farnesol dehydrogenase activity|farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047886 GO:0047885 biolink:MolecularActivity farnesol 2-isomerase activity Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol. EC:5.2.1.9|KEGG_REACTION:R03265|MetaCyc:FARNESOL-2-ISOMERASE-RXN|RHEA:13401 go.json 2-trans,6-trans-farnesol 2-cis-trans-isomerase activity|farnesol isomerase activity http://purl.obolibrary.org/obo/GO_0047885 GO:0047884 biolink:MolecularActivity FAD diphosphatase activity Catalysis of the reaction: FAD + H2O = AMP + FMN. EC:3.6.1.18|MetaCyc:FAD-PYROPHOSPHATASE-RXN|RHEA:13889 go.json FAD nucleotidohydrolase activity|FAD pyrophosphatase activity|FAD pyrophosphohydrolase activity|flavin adenine dinucleotide pyrophosphatase activity|flavine adenine dinucleotide pyrophosphatase activity|riboflavin adenine dinucleotide pyrophosphatase activity|riboflavine adenine dinucleotide pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0047884 GO:0047883 biolink:MolecularActivity ethanolamine oxidase activity Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2. EC:1.4.3.8|MetaCyc:ETHANOLAMINE-OXIDASE-RXN|RHEA:18581 go.json ethanolamine:oxygen oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0047883 GO:0047882 biolink:MolecularActivity estradiol 6-beta-monooxygenase activity Catalysis of the reaction: AH(2) + estradiol-17beta + O2 = 6beta-hydroxyestradiol-17beta + A + H2O. EC:1.14.99.11|KEGG_REACTION:R03086|MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN|RHEA:19137 go.json estradiol 6-beta-hydroxylase activity|estradiol 6b-hydroxylase activity|estradiol 6b-monooxygenase activity|estradiol 6beta-hydroxylase activity|estradiol 6beta-monooxygenase activity|estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating) http://purl.obolibrary.org/obo/GO_0047882 GO:0033249 biolink:BiologicalProcess positive regulation of penicillin catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json positive regulation of penicillin breakdown|positive regulation of penicillin catabolism|positive regulation of penicillin degradation http://purl.obolibrary.org/obo/GO_0033249 GO:0008289 biolink:MolecularActivity lipid binding Binding to a lipid. go.json http://purl.obolibrary.org/obo/GO_0008289 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_pir|goslim_plant|goslim_yeast|prokaryote_subset GO:0008288 biolink:MolecularActivity boss receptor activity Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. go.json sevenless receptor activity http://purl.obolibrary.org/obo/GO_0008288 GO:0008287 biolink:CellularComponent protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. go.json http://purl.obolibrary.org/obo/GO_0008287 goslim_pir GO:0008286 biolink:BiologicalProcess insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. go.json daf-2 receptor signaling pathway|insulin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0008286 GO:0008285 biolink:BiologicalProcess negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation. go.json down regulation of cell proliferation|down-regulation of cell proliferation|downregulation of cell proliferation|inhibition of cell proliferation|negative regulation of cell proliferation http://purl.obolibrary.org/obo/GO_0008285 GO:0033240 biolink:BiologicalProcess positive regulation of amine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. go.json positive regulation of amine metabolism|positive regulation of cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0033240 GO:0008295 biolink:BiologicalProcess spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. MetaCyc:BSUBPOLYAMSYN-PWY|MetaCyc:POLYAMINSYN3-PWY go.json spermidine anabolism|spermidine biosynthesis|spermidine formation|spermidine synthesis http://purl.obolibrary.org/obo/GO_0008295 GO:0008294 biolink:MolecularActivity calcium- and calmodulin-responsive adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin. Reactome:R-HSA-111930|Reactome:R-HSA-442715 go.json calcium- and calmodulin-responsive adenylyl cyclase activity|calcium/calmodulin-responsive adenylate cyclase activity http://purl.obolibrary.org/obo/GO_0008294 GO:0008293 biolink:BiologicalProcess torso signaling pathway The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json torso signalling pathway http://purl.obolibrary.org/obo/GO_0008293 GO:0008292 biolink:BiologicalProcess acetylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. go.json acetylcholine anabolism|acetylcholine biosynthesis|acetylcholine formation|acetylcholine synthesis http://purl.obolibrary.org/obo/GO_0008292 GO:0008291 biolink:BiologicalProcess acetylcholine metabolic process The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. go.json acetylcholine metabolism http://purl.obolibrary.org/obo/GO_0008291 GO:0008290 biolink:CellularComponent F-actin capping protein complex A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. go.json http://purl.obolibrary.org/obo/GO_0008290 goslim_pir GO:0033248 biolink:BiologicalProcess negative regulation of penicillin catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json negative regulation of penicillin breakdown|negative regulation of penicillin catabolism|negative regulation of penicillin degradation http://purl.obolibrary.org/obo/GO_0033248 GO:0033247 biolink:BiologicalProcess regulation of penicillin catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json regulation of penicillin breakdown|regulation of penicillin catabolism|regulation of penicillin degradation http://purl.obolibrary.org/obo/GO_0033247 GO:0033246 biolink:BiologicalProcess positive regulation of penicillin metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json positive regulation of penicillin metabolism http://purl.obolibrary.org/obo/GO_0033246 GO:0033245 biolink:BiologicalProcess negative regulation of penicillin metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json negative regulation of penicillin metabolism http://purl.obolibrary.org/obo/GO_0033245 GO:0033244 biolink:BiologicalProcess regulation of penicillin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json regulation of penicillin metabolism http://purl.obolibrary.org/obo/GO_0033244 GO:0033243 biolink:BiologicalProcess positive regulation of amine catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. go.json positive regulation of amine breakdown|positive regulation of amine catabolism|positive regulation of amine degradation http://purl.obolibrary.org/obo/GO_0033243 GO:0033242 biolink:BiologicalProcess negative regulation of amine catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. go.json negative regulation of amine breakdown|negative regulation of amine catabolism|negative regulation of amine degradation|negative regulation of cellular amine catabolic process http://purl.obolibrary.org/obo/GO_0033242 GO:0033241 biolink:BiologicalProcess regulation of amine catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. go.json regulation of amine breakdown|regulation of amine catabolism|regulation of amine degradation|regulation of cellular amine catabolic process http://purl.obolibrary.org/obo/GO_0033241 GO:0033239 biolink:BiologicalProcess negative regulation of amine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. go.json negative regulation of amine metabolism|negative regulation of cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0033239 GO:0033238 biolink:BiologicalProcess regulation of amine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. go.json regulation of amine metabolism|regulation of cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0033238 GO:0008299 biolink:BiologicalProcess isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. MetaCyc:POLYISOPRENSYN-PWY go.json isoprenoid anabolism|isoprenoid biosynthesis|isoprenoid formation|isoprenoid synthesis|polyisoprenoid anabolism|polyisoprenoid biosynthesis|polyisoprenoid biosynthetic process|polyisoprenoid formation|polyisoprenoid synthesis|polyterpene biosynthesis|polyterpene biosynthetic process http://purl.obolibrary.org/obo/GO_0008299 GO:0008298 biolink:BiologicalProcess intracellular mRNA localization Any process in which mRNA is transported to, or maintained in, a specific location within the cell. go.json establishment and maintenance of intracellular RNA localization|intracellular mRNA localisation|intracellular mRNA positioning|mRNA localization, intracellular|mRNA positioning, intracellular http://purl.obolibrary.org/obo/GO_0008298 GO:0008297 biolink:MolecularActivity single-stranded DNA exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. go.json single-stranded DNA specific exodeoxyribonuclease activity|ssDNA-specific exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0008297 GO:0008296 biolink:MolecularActivity 3'-5'-DNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. Reactome:R-HSA-9023943 go.json 3'-5' exodeoxyribonuclease activity|3'-5'-exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0008296 GO:0033237 biolink:MolecularActivity obsolete 11-beta-hydroxysteroid dehydrogenase (NADP+) activity OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+. go.json 11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11beta-hydroxysteroid:NADP+ 11-oxidoreductase|beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase activity True http://purl.obolibrary.org/obo/GO_0033237 GO:0033236 biolink:MolecularActivity obsolete 11-beta-hydroxysteroid dehydrogenase (NAD+) activity OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+. go.json 11-beta-hydroxysteroid dehydrogenase (NAD+) activity True http://purl.obolibrary.org/obo/GO_0033236 GO:0033235 biolink:BiologicalProcess positive regulation of protein sumoylation Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. go.json positive regulation of sumoylation http://purl.obolibrary.org/obo/GO_0033235 GO:0033234 biolink:BiologicalProcess negative regulation of protein sumoylation Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein. go.json negative regulation of sumoylation http://purl.obolibrary.org/obo/GO_0033234 GO:0033233 biolink:BiologicalProcess regulation of protein sumoylation Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. go.json regulation of sumoylation http://purl.obolibrary.org/obo/GO_0033233 GO:0033232 biolink:MolecularActivity ABC-type D-methionine transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out). EC:7.4.2.11|RHEA:29779 go.json ATP-dependent D-methionine transporter activity|ATP-dependent methionine transmembrane transporter activity|ATPase-coupled D-methionine transporter activity|ATPase-coupled methionine transmembrane transporter activity|D-methionine exporter|D-methionine importer|D-methionine transmembrane transporter activity|D-methionine transporter activity|D-methionine-exporting ATPase activity|D-methionine-importing ATPase activity|D-methionine-transporting ATPase activity|methionine transmembrane-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033232 GO:0033231 biolink:BiologicalProcess carbohydrate export The directed movement of carbohydrates out of a cell or organelle. go.json http://purl.obolibrary.org/obo/GO_0033231 GO:0033230 biolink:MolecularActivity ABC-type cysteine transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out). RHEA:32795 go.json ATP-dependent cysteine transporter activity|ATPase-coupled cysteine transmembrane transporter activity|ATPase-coupled cysteine transporter activity|cysteine exporter|cysteine-exporting ATPase activity|cysteine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033230 GO:0033229 biolink:MolecularActivity cysteine transmembrane transporter activity Enables the transfer of cysteine from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0033229 GO:0033228 biolink:BiologicalProcess cysteine export across plasma membrane The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region. go.json cysteine export http://purl.obolibrary.org/obo/GO_0033228 GO:0033227 biolink:BiologicalProcess dsRNA transport The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0033227 GO:0008269 biolink:MolecularActivity JAK pathway signal transduction adaptor activity The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. go.json http://purl.obolibrary.org/obo/GO_0008269 GO:0008268 biolink:MolecularActivity obsolete receptor signaling protein tyrosine kinase signaling protein activity OBSOLETE. (Was not defined before being made obsolete). go.json receptor signaling protein tyrosine kinase signaling protein activity|receptor signalling protein tyrosine kinase signalling protein activity True http://purl.obolibrary.org/obo/GO_0008268 GO:0008267 biolink:MolecularActivity poly-glutamine tract binding Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. go.json http://purl.obolibrary.org/obo/GO_0008267 GO:0008266 biolink:MolecularActivity poly(U) RNA binding Binding to a sequence of uracil residues in an RNA molecule. go.json poly(U) binding http://purl.obolibrary.org/obo/GO_0008266 GO:0008265 biolink:MolecularActivity Mo-molybdopterin cofactor sulfurase activity Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase. EC:2.8.1.9|Reactome:R-HSA-947499 go.json Mo-molybdopterin cofactor sulphurase activity|molybdopterin cofactor sulfurase activity|molybdopterin synthase sulfurylase activity http://purl.obolibrary.org/obo/GO_0008265 GO:0008264 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008264 GO:0008263 biolink:MolecularActivity pyrimidine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. go.json G/T-mismatch-specific thymine-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0008263 GO:0008273 biolink:MolecularActivity calcium, potassium:sodium antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). Reactome:R-HSA-2514891|Reactome:R-HSA-425678|Reactome:R-HSA-5625841|Reactome:R-HSA-5626270|Reactome:R-HSA-5626316|Reactome:R-HSA-5626356 go.json potassium-dependent sodium/calcium exchanger http://purl.obolibrary.org/obo/GO_0008273 GO:0008272 biolink:BiologicalProcess sulfate transport The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json sulphate transport http://purl.obolibrary.org/obo/GO_0008272 GO:0008271 biolink:MolecularActivity secondary active sulfate transmembrane transporter activity Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json secondary active sulphate transmembrane transporter activity|sulfate porter activity|sulphate porter activity http://purl.obolibrary.org/obo/GO_0008271 GO:0008270 biolink:MolecularActivity zinc ion binding Binding to a zinc ion (Zn). go.json Zn binding|zinc binding http://purl.obolibrary.org/obo/GO_0008270 GO:0033226 biolink:MolecularActivity 2-aminoethylphosphonate binding Binding to 2-aminoethylphosphonate. go.json 2-phosphonoethylamine binding|ciliatine binding http://purl.obolibrary.org/obo/GO_0033226 GO:0033225 biolink:MolecularActivity ATPase-coupled 2-aminoethylphosphonate transporter activity Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in). RHEA:32775 go.json 2-aminoethylphosphonate transmembrane transporter activity|2-aminoethylphosphonate transporting ATPase activity|2-aminoethylphosphonate-transporting ATPase activity|2-phosphonoethylamine transmembrane transporter activity|2-phosphonoethylamine transporting ATPase activity|ATP-dependent 2-aminoethylphosphonate transporter activity|ciliatine transporter activity|ciliatine transportingATPase activity http://purl.obolibrary.org/obo/GO_0033225 GO:0033224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033224 GO:0033223 biolink:BiologicalProcess 2-aminoethylphosphonate transport The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 2-phosphonoethylamine transport|ciliatine transport http://purl.obolibrary.org/obo/GO_0033223 GO:0033222 biolink:MolecularActivity xylose binding Binding to the D- or L-enantiomer of xylose. go.json http://purl.obolibrary.org/obo/GO_0033222 GO:0033221 biolink:MolecularActivity ATPase-coupled urea transmembrane transporter activity Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in). RHEA:32803 go.json ATP-dependent urea transmembrane transporter activity|carbamide-transporting ATPase activity|urea-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033221 GO:0033220 biolink:MolecularActivity obsolete ATPase-coupled amide-transporter activity OBSOLETE. Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in). go.json ATP-dependent amide-transporter activity|amide-transporting ATPase activity True http://purl.obolibrary.org/obo/GO_0033220 GO:0033219 biolink:MolecularActivity urea binding Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2. go.json http://purl.obolibrary.org/obo/GO_0033219 GO:0033218 biolink:MolecularActivity amide binding Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. go.json http://purl.obolibrary.org/obo/GO_0033218 goslim_pir GO:0033217 biolink:BiologicalProcess regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. go.json regulation of transcription from RNA polymerase II promoter in response to iron deficiency http://purl.obolibrary.org/obo/GO_0033217 GO:0033216 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033216 GO:0008279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008279 GO:0008278 biolink:CellularComponent cohesin complex A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). go.json 14S cohesin|9S cohesin|SMC complex|SMC/kleisin ring complex|Smc1-Smc3 complex|cohesin core heterodimer|nuclear cohesin complex http://purl.obolibrary.org/obo/GO_0008278 goslim_pir GO:0008277 biolink:BiologicalProcess regulation of G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. go.json regulation of G protein coupled receptor protein signaling pathway|regulation of G protein coupled receptor protein signalling pathway|regulation of G-protein coupled receptor protein signaling pathway|regulation of G-protein coupled receptor protein signalling pathway|regulation of G-protein-coupled receptor protein signalling pathway|regulation of GPCR protein signaling pathway|regulation of GPCR protein signalling pathway http://purl.obolibrary.org/obo/GO_0008277 GO:0008276 biolink:MolecularActivity protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. Reactome:R-HSA-9632182 go.json protein methylase activity http://purl.obolibrary.org/obo/GO_0008276 GO:0008275 biolink:CellularComponent gamma-tubulin small complex A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. go.json Tub4 complex|gamma-tubulin small complex, centrosomal|gamma-tubulin small complex, mitotic spindle pole body|gamma-tubulin small complex, spindle pole body|gammaTuSC http://purl.obolibrary.org/obo/GO_0008275 GO:0008274 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008274 GO:0008284 biolink:BiologicalProcess positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation. go.json activation of cell proliferation|positive regulation of cell proliferation|stimulation of cell proliferation|up regulation of cell proliferation|up-regulation of cell proliferation|upregulation of cell proliferation http://purl.obolibrary.org/obo/GO_0008284 GO:0008283 biolink:BiologicalProcess cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. go.json cell proliferation http://purl.obolibrary.org/obo/GO_0008283 goslim_agr|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_mouse|goslim_pir GO:0008282 biolink:CellularComponent inward rectifying potassium channel A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity. go.json ATP-sensitive potassium channel complex|KCNJ11-SUR complex|KCNJ11-SURx complex|KCNJ8-SUR complex|KCNJ8-SURx complex|Kir6-SUR complex|Kir6.1-SUR complex|Kir6.1-SURx complex|Kir6.2-SUR complex|Kir6.2-SURx complex|Kir6.x complex|Kir6.x-SURx complex|inward rectifying K+ channel http://purl.obolibrary.org/obo/GO_0008282 GO:0008281 biolink:MolecularActivity sulfonylurea receptor activity Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json sulphonylurea receptor activity http://purl.obolibrary.org/obo/GO_0008281 GO:0008280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008280 GO:0033215 biolink:BiologicalProcess reductive iron assimilation A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins. go.json iron assimilation by reduction and transport http://purl.obolibrary.org/obo/GO_0033215 GO:0033214 biolink:BiologicalProcess siderophore-dependent iron import into cell A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors. go.json iron assimilation by capture and transport|iron assimilation by chelation and transport|iron chelate transport http://purl.obolibrary.org/obo/GO_0033214 GO:0033213 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033213 GO:0033212 biolink:BiologicalProcess iron import into cell The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. go.json ferrous ion import|ferrous iron import|ferrous iron uptake|iron assimilation http://purl.obolibrary.org/obo/GO_0033212 GO:0033211 biolink:BiologicalProcess adiponectin-activated signaling pathway The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json adipocytokine signaling pathway|adiponectin-mediated signaling pathway|adiponectin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0033211 GO:0033210 biolink:BiologicalProcess leptin-mediated signaling pathway The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. go.json adipocytokine signaling pathway|leptin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0033210 GO:0033209 biolink:BiologicalProcess tumor necrosis factor-mediated signaling pathway The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TNF-alpha-mediated signaling pathway|adipocytokine signaling pathway|tumor necrosis factor alpha-mediated signaling pathway|tumor necrosis factor-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0033209 GO:0033208 biolink:MolecularActivity UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide. go.json Sda beta 1,4GalNAc transferase|UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0033208 GO:0033207 biolink:MolecularActivity beta-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage. go.json beta-1,4-GalNAc transferase activity http://purl.obolibrary.org/obo/GO_0033207 GO:0033206 biolink:BiologicalProcess meiotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells. go.json cytokinesis after meiosis http://purl.obolibrary.org/obo/GO_0033206 GO:0033205 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033205 GO:0008249 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008249 GO:0008248 biolink:MolecularActivity obsolete pre-mRNA splicing factor activity OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA. go.json pre-mRNA splicing factor activity True http://purl.obolibrary.org/obo/GO_0008248 GO:0008247 biolink:CellularComponent 1-alkyl-2-acetylglycerophosphocholine esterase complex An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF). go.json 2-acetyl-1-alkylglycerophosphocholine esterase complex|platelet-activating factor acetylhydrolase complex http://purl.obolibrary.org/obo/GO_0008247 GO:0008246 biolink:MolecularActivity obsolete electron transfer flavoprotein OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system. go.json ETF|electron transfer flavoprotein True http://purl.obolibrary.org/obo/GO_0008246 GO:0008245 biolink:CellularComponent obsolete lysosomal membrane hydrogen-transporting ATPase OBSOLETE. (Was not defined before being made obsolete). go.json V-ATPase|lysosomal membrane hydrogen-transporting ATPase True http://purl.obolibrary.org/obo/GO_0008245 GO:0008244 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008244 GO:0008243 biolink:MolecularActivity obsolete plasminogen activator activity OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin. go.json abbokinase activity|cellular plasminogen activator activity|double-chain urokinase-type plasminogen activator|plasminogen activator activity|plasminogen activator, tissue-type|t-PA|t-plasminogen activator activity|tPA activity|tissue plasminogen activator activity|tissue-type plasminogen activator activity|two-chain urokinase-type plasminogen activator|u-PA|u-plasminogen activator activity|uPA|urinary esterase A|urinary plasminogen activator activity|urokinase activity|urokinase plasminogen activator|urokinase-type plasminogen activator True http://purl.obolibrary.org/obo/GO_0008243 GO:0008242 biolink:MolecularActivity omega peptidase activity Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. EC:3.4.19.- go.json peptidase activity, acting on peptides containing modified amino acids http://purl.obolibrary.org/obo/GO_0008242 GO:0008241 biolink:MolecularActivity peptidyl-dipeptidase activity Catalysis of the release of C-terminal dipeptides from a polypeptide chain. EC:3.4.15.- go.json http://purl.obolibrary.org/obo/GO_0008241 GO:0008251 biolink:MolecularActivity tRNA-specific adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. Reactome:R-HSA-6782311|Reactome:R-HSA-6782336 go.json tRNA-adenosine deaminase activity http://purl.obolibrary.org/obo/GO_0008251 GO:0008250 biolink:CellularComponent oligosaccharyltransferase complex A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected. go.json OST complex|oligosaccharyl transferase complex http://purl.obolibrary.org/obo/GO_0008250 GO:0033204 biolink:MolecularActivity ribonuclease P RNA binding Binding to RNA subunit of ribonuclease P. go.json RNase P RNA binding http://purl.obolibrary.org/obo/GO_0033204 GO:0033203 biolink:CellularComponent DNA helicase A complex A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction. go.json http://purl.obolibrary.org/obo/GO_0033203 GO:0033202 biolink:CellularComponent DNA helicase complex A protein complex that possesses DNA helicase activity. go.json http://purl.obolibrary.org/obo/GO_0033202 goslim_metagenomics|goslim_pir GO:0033201 biolink:MolecularActivity alpha-1,4-glucan synthase activity Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP. EC:2.4.1.21|RHEA:18189 go.json 1,4-alpha-glucan synthase activity http://purl.obolibrary.org/obo/GO_0033201 GO:0033200 biolink:MolecularActivity inositol heptakisphosphate 5-kinase activity Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. go.json IP7 5-kinase activity|diphosphoinositol-pentakisphosphate 5-kinase activity http://purl.obolibrary.org/obo/GO_0033200 GO:0008259 biolink:BiologicalProcess obsolete transforming growth factor beta ligand binding to type I receptor OBSOLETE. (Was not defined before being made obsolete). go.json TGF-beta ligand binding to type I receptor|TGFbeta ligand binding to type I receptor|transforming growth factor beta ligand binding to type I receptor True http://purl.obolibrary.org/obo/GO_0008259 GO:0008258 biolink:BiologicalProcess head involution Movement of the anterior ectoderm to the interior of the embryo. go.json http://purl.obolibrary.org/obo/GO_0008258 GO:0008257 biolink:MolecularActivity protein histidine tele-kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine. EC:2.7.13.2|MetaCyc:2.7.13.2-RXN|RHEA:11860 go.json ATP:protein-L-histidine N-tele-phosphotransferase activity|ATP:protein-L-histidine Ntau-phosphotransferase activity|protein-histidine tele-kinase activity http://purl.obolibrary.org/obo/GO_0008257 GO:0008256 biolink:MolecularActivity protein histidine pros-kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine. EC:2.7.13.1|MetaCyc:2.7.13.1-RXN|RHEA:22720 go.json ATP:protein-L-histidine N-pros-phosphotransferase activity|ATP:protein-L-histidine Npi-phosphotransferase activity|protein-histidine pros-kinase activity http://purl.obolibrary.org/obo/GO_0008256 GO:0008255 biolink:MolecularActivity ecdysis-triggering hormone activity The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system. go.json http://purl.obolibrary.org/obo/GO_0008255 GO:0008254 biolink:MolecularActivity 3'-nucleotidase activity Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. EC:3.1.3.6|MetaCyc:3-NUCLEOTID-RXN|RHEA:10144 go.json 3' nucleotidase activity|3'-mononucleotidase activity|3'-phosphatase activity|3'-ribonucleotidase activity|3'-ribonucleotide phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008254 GO:0008253 biolink:MolecularActivity 5'-nucleotidase activity Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. EC:3.1.3.5|MetaCyc:5-NUCLEOTID-RXN|RHEA:12484|Reactome:R-HSA-109278|Reactome:R-HSA-109291|Reactome:R-HSA-109380|Reactome:R-HSA-109387|Reactome:R-HSA-109415|Reactome:R-HSA-109449|Reactome:R-HSA-109470|Reactome:R-HSA-109480|Reactome:R-HSA-109514|Reactome:R-HSA-5694126|Reactome:R-HSA-74248|Reactome:R-HSA-8940070|Reactome:R-HSA-8940074|Reactome:R-HSA-9755078 go.json 5' nucleotidase activity|5'-AMP nucleotidase|5'-AMPase|5'-adenylic phosphatase|5'-mononucleotidase activity|5'-ribonucleotide phosphohydrolase activity|AMP phosphatase|AMP phosphohydrolase|AMPase|UMPase|adenosine 5'-phosphatase|adenosine monophosphatase|snake venom 5'-nucleotidase|thimidine monophosphate nucleotidase|uridine 5'-nucleotidase http://purl.obolibrary.org/obo/GO_0008253 GO:0008252 biolink:MolecularActivity nucleotidase activity Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. RHEA:22140 go.json NSP I|NSP II|acid nucleotidase activity|deoxyinosine-activated nucleotidase (DIAN)|deoxyribonucleoside-activated nucleotidase (DAN)|nucleotide phosphohydrolase activity|nucleotide-specific phosphatase activity http://purl.obolibrary.org/obo/GO_0008252 GO:0008262 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008262 GO:0008261 biolink:MolecularActivity allatostatin receptor activity Combining with allatostatin to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0008261 GO:0008260 biolink:MolecularActivity succinyl-CoA:3-oxo-acid CoA-transferase activity Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. EC:2.8.3.5|MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN|RHEA:24564|Reactome:R-HSA-74177 go.json 3-oxo-CoA transferase activity|3-oxoacid CoA dehydrogenase activity|3-oxoacid CoA-transferase activity|3-oxoacid coenzyme A-transferase activity|Succinyl-CoA:3-ketoacid-CoA transferase|acetoacetate succinyl-CoA transferase activity|acetoacetyl coenzyme A-succinic thiophorase activity|succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity|succinyl-CoA 3-ketoacid-CoA transferase activity|succinyl-CoA transferase activity http://purl.obolibrary.org/obo/GO_0008260 GO:0008229 biolink:MolecularActivity obsolete opsonin activity OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis. go.json opsonin activity True http://purl.obolibrary.org/obo/GO_0008229 GO:0008228 biolink:BiologicalProcess opsonization The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. Wikipedia:Opsonin go.json http://purl.obolibrary.org/obo/GO_0008228 GO:0008227 biolink:MolecularActivity G protein-coupled amine receptor activity Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G-protein coupled amine receptor activity|amine receptor activity, G-protein coupled|biogenic amine receptor http://purl.obolibrary.org/obo/GO_0008227 GO:0008226 biolink:MolecularActivity tyramine receptor activity Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine. go.json http://purl.obolibrary.org/obo/GO_0008226 GO:0008225 biolink:MolecularActivity obsolete Gram-negative antibacterial peptide activity OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells. go.json Gram-negative antibacterial peptide activity True http://purl.obolibrary.org/obo/GO_0008225 GO:0008224 biolink:MolecularActivity obsolete Gram-positive antibacterial peptide activity OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells. go.json Gram-positive antibacterial peptide activity True http://purl.obolibrary.org/obo/GO_0008224 GO:0008223 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008223 GO:0008222 biolink:MolecularActivity obsolete tumor antigen OBSOLETE. (Was not defined before being made obsolete). go.json tumor antigen True http://purl.obolibrary.org/obo/GO_0008222 GO:0008221 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008221 GO:0008220 biolink:BiologicalProcess obsolete necrosis OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism. go.json necrosis True http://purl.obolibrary.org/obo/GO_0008220 GO:0008239 biolink:MolecularActivity dipeptidyl-peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. EC:3.4.14.1|EC:3.4.14.2|EC:3.4.14.4|EC:3.4.14.5 go.json http://purl.obolibrary.org/obo/GO_0008239 GO:0008238 biolink:MolecularActivity exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. go.json exoprotease activity http://purl.obolibrary.org/obo/GO_0008238 GO:0008237 biolink:MolecularActivity metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Reactome:R-HSA-157629|Reactome:R-HSA-157632|Reactome:R-HSA-193679|Reactome:R-HSA-2022368|Reactome:R-HSA-2022393|Reactome:R-HSA-2022396|Reactome:R-HSA-2022399|Reactome:R-HSA-2220944|Reactome:R-HSA-2220976|Reactome:R-HSA-2666278|Reactome:R-HSA-2730752|Reactome:R-HSA-3928660|Reactome:R-HSA-5211340|Reactome:R-HSA-5211356|Reactome:R-HSA-5211387|Reactome:R-HSA-5211391|Reactome:R-HSA-5211400|Reactome:R-HSA-5211405|Reactome:R-HSA-8986181|Reactome:R-HSA-9013284|Reactome:R-HSA-9604264|Reactome:R-HSA-9662837|Reactome:R-HSA-9759522 go.json metalloprotease activity|metalloproteinase activity http://purl.obolibrary.org/obo/GO_0008237 GO:0047801 biolink:MolecularActivity L-cysteine transaminase activity Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. EC:2.6.1.3|MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN|RHEA:17441|Reactome:R-HSA-9012597 go.json L-cysteine:2-oxoglutarate aminotransferase activity|cysteine aminotransferase activity|cysteine transaminase activity http://purl.obolibrary.org/obo/GO_0047801 GO:0047800 biolink:MolecularActivity cysteamine dioxygenase activity Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine. EC:1.13.11.19|KEGG_REACTION:R02467|MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN|RHEA:14409|Reactome:R-HSA-6814153 go.json 2-aminoethanethiol:oxygen oxidoreductase activity|cysteamine oxygenase activity|cysteamine:oxygen oxidoreductase activity|persulfurase activity http://purl.obolibrary.org/obo/GO_0047800 GO:0008236 biolink:MolecularActivity serine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). Reactome:R-HSA-1461993|Reactome:R-HSA-2022383|Reactome:R-HSA-3132753|Reactome:R-HSA-6801766 go.json serine protease activity http://purl.obolibrary.org/obo/GO_0008236 GO:0008235 biolink:MolecularActivity metalloexopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. go.json http://purl.obolibrary.org/obo/GO_0008235 GO:0008234 biolink:MolecularActivity cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. Reactome:R-HSA-2022381|Reactome:R-HSA-2467775|Reactome:R-HSA-2467809|Reactome:R-HSA-5660752|Reactome:R-HSA-9757951 go.json cysteine protease activity|thiol protease activity http://purl.obolibrary.org/obo/GO_0008234 GO:0008233 biolink:MolecularActivity peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. EC:3.4.-.-|Reactome:R-HSA-205112|Reactome:R-HSA-3000243|Reactome:R-HSA-3000263|Reactome:R-HSA-3065958|Reactome:R-HSA-3065959|Reactome:R-HSA-3139027|Reactome:R-HSA-376149|Reactome:R-HSA-4167501|Reactome:R-HSA-448678|Reactome:R-HSA-5655483|Reactome:R-HSA-5684864|Reactome:R-HSA-5685902|Reactome:R-HSA-6803060 go.json hydrolase, acting on peptide bonds|peptidase activity, acting on D-amino acid peptides|peptidase activity, acting on L-amino acid peptides|peptide hydrolase activity|protease activity|proteinase activity http://purl.obolibrary.org/obo/GO_0008233 goslim_candida|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_pir|goslim_yeast GO:0008232 biolink:CellularComponent activator ecdysone receptor complex A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes. go.json activator ecdysone receptor holocomplex http://purl.obolibrary.org/obo/GO_0008232 GO:0008231 biolink:CellularComponent repressor ecdysone receptor complex A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes. go.json repressor ecdysone receptor holocomplex http://purl.obolibrary.org/obo/GO_0008231 GO:0008230 biolink:CellularComponent ecdysone receptor holocomplex A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes. go.json http://purl.obolibrary.org/obo/GO_0008230 GO:0047809 biolink:MolecularActivity D-2-hydroxy-acid dehydrogenase activity Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate. EC:1.1.99.6|KEGG_REACTION:R00297|MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN|RHEA:15089 go.json (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity|2-hydroxy acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047809 GO:0008240 biolink:MolecularActivity tripeptidyl-peptidase activity Catalysis of the release of an N-terminal tripeptide from a polypeptide. EC:3.4.14.10|EC:3.4.14.9|MetaCyc:3.4.14.10-RXN|MetaCyc:3.4.14.9-RXN go.json http://purl.obolibrary.org/obo/GO_0008240 GO:0047808 biolink:MolecularActivity D(-)-tartrate dehydratase activity Catalysis of the reaction: D-tartrate = H2O + oxaloacetate. EC:4.2.1.81|KEGG_REACTION:R00340|MetaCyc:D--TARTRATE-DEHYDRATASE-RXN|RHEA:18289 go.json (S,S)-tartrate hydro-lyase (oxaloacetate-forming)|(S,S)-tartrate hydro-lyase activity|D-tartrate dehydratase activity http://purl.obolibrary.org/obo/GO_0047808 GO:0047807 biolink:MolecularActivity cytokinin 7-beta-glucosyltransferase activity Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event. EC:2.4.1.118|KEGG_REACTION:R04071|MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:23272 go.json UDP-glucose-zeatin 7-glucosyltransferase activity|UDP-glucose:zeatin 7-glucosyltransferase activity|UDPglucose:zeatin 7-glucosyltransferase activity|cytokinin 7-b-glucosyltransferase activity|cytokinin 7-glucosyltransferase activity|uridine diphosphoglucose-zeatin 7-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047807 GO:0047806 biolink:MolecularActivity cytochrome-c3 hydrogenase activity Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3. EC:1.12.2.1|MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN|RHEA:20625|UM-BBD_enzymeID:e0481 go.json H(2):ferricytochrome c3 oxidoreductase activity|H2:ferricytochrome c3 oxidoreductase activity|cytochrome c3 reductase activity|cytochrome hydrogenase activity|hydrogen:ferricytochrome-c3 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047806 GO:0047805 biolink:MolecularActivity cytidylate cyclase activity Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+. EC:4.6.1.6|KEGG_REACTION:R00574|MetaCyc:CYTIDYLATE-CYCLASE-RXN|RHEA:14737 go.json 3',5'-cyclic-CMP synthase activity|3'5'-cyclic-CMP synthase activity|CTP diphosphate-lyase (cyclizing)|CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)|cytidyl cyclase activity|cytidylyl cyclase activity http://purl.obolibrary.org/obo/GO_0047805 GO:0047804 biolink:MolecularActivity cysteine-S-conjugate beta-lyase activity Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. EC:4.4.1.13|MetaCyc:RXN-6763|RHEA:18121 go.json L-cysteine-S-conjugate thiol-lyase (deaminating) activity|L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)|cysteine conjugate beta-lyase activity|cysteine-S-conjugate b-lyase activity|glutamine transaminase K/cysteine conjugate beta-lyase activity http://purl.obolibrary.org/obo/GO_0047804 GO:0047803 biolink:MolecularActivity cysteine lyase activity Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide. EC:4.4.1.10|MetaCyc:CYSTEINE-LYASE-RXN|RHEA:20916 go.json L-cysteine hydrogen-sulfide-lyase (adding sulfite)|L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)|cysteine (sulfite) lyase activity http://purl.obolibrary.org/obo/GO_0047803 GO:0047802 biolink:MolecularActivity cysteine-conjugate transaminase activity Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate. EC:2.6.1.75|KEGG_REACTION:R04338|MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN|RHEA:13485 go.json S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity|cysteine conjugate aminotransferase activity|cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1) http://purl.obolibrary.org/obo/GO_0047802 GO:0033196 biolink:MolecularActivity tryparedoxin peroxidase activity Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O. MetaCyc:1.11.1.15-RXN go.json TXNPx activity http://purl.obolibrary.org/obo/GO_0033196 GO:0033195 biolink:BiologicalProcess response to alkyl hydroperoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group. go.json http://purl.obolibrary.org/obo/GO_0033195 GO:0033194 biolink:BiologicalProcess response to hydroperoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. go.json http://purl.obolibrary.org/obo/GO_0033194 GO:0033193 biolink:CellularComponent Lsd1/2 complex A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast. go.json SAPHIRE complex|Swm complex|Swm1/2 complex http://purl.obolibrary.org/obo/GO_0033193 GO:0033192 biolink:MolecularActivity calmodulin-dependent protein phosphatase activity Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. Reactome:R-HSA-2730849|Reactome:R-HSA-4551451 go.json Ca2+/CaM-dependent protein phosphatase activity|calcineurin activity|calcium- and calmodulin-dependent protein phosphatase activity|calcium/calmodulin-dependent protein phosphatase activity http://purl.obolibrary.org/obo/GO_0033192 GO:0033191 biolink:MolecularActivity macrophomate synthase activity Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate. go.json http://purl.obolibrary.org/obo/GO_0033191 GO:0033190 biolink:MolecularActivity solanapyrone synthase activity Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A. go.json http://purl.obolibrary.org/obo/GO_0033190 GO:0033199 biolink:MolecularActivity obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity OBSOLETE. Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. go.json inositol heptakisphosphate 4-kinase or 6-kinase activity True http://purl.obolibrary.org/obo/GO_0033199 GO:0033198 biolink:BiologicalProcess response to ATP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. go.json response to adenosine 5'-triphosphate|response to adenosine triphosphate http://purl.obolibrary.org/obo/GO_0033198 GO:0033197 biolink:BiologicalProcess response to vitamin E Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. go.json response to DL-alpha-tocopherol acetate|response to DL-alpha-tocopheryl acetate|response to O-Acetyl-alpha-tocopherol http://purl.obolibrary.org/obo/GO_0033197 GO:0033185 biolink:CellularComponent dolichol-phosphate-mannose synthase complex A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively. go.json DPM synthase complex|dolichyl-phosphate beta-D-mannosyltransferase complex http://purl.obolibrary.org/obo/GO_0033185 GO:0033184 biolink:BiologicalProcess positive regulation of histone ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. go.json http://purl.obolibrary.org/obo/GO_0033184 GO:0033183 biolink:BiologicalProcess negative regulation of histone ubiquitination Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. go.json http://purl.obolibrary.org/obo/GO_0033183 GO:0033182 biolink:BiologicalProcess regulation of histone ubiquitination Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. go.json http://purl.obolibrary.org/obo/GO_0033182 GO:0033181 biolink:CellularComponent plasma membrane proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the plasma membrane. go.json plasma membrane hydrogen ion-transporting ATPase http://purl.obolibrary.org/obo/GO_0033181 GO:0033180 biolink:CellularComponent proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. go.json http://purl.obolibrary.org/obo/GO_0033180 GO:0033189 biolink:BiologicalProcess response to vitamin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. go.json response to retinol http://purl.obolibrary.org/obo/GO_0033189 GO:0033188 biolink:MolecularActivity sphingomyelin synthase activity Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. EC:2.7.8.27|KEGG_REACTION:R08969|MetaCyc:2.7.8.27-RXN|RHEA:18765|Reactome:R-HSA-429786|Reactome:R-HSA-429798 go.json SM synthase activity|SMS1|SMS2|ceramide:phosphatidylcholine cholinephosphotransferase activity|phosphatidylcholine:ceramide cholinephosphotransferase activity http://purl.obolibrary.org/obo/GO_0033188 GO:0033187 biolink:MolecularActivity obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. go.json inositol hexakisphosphate 4-kinase or 6-kinase activity True http://purl.obolibrary.org/obo/GO_0033187 GO:0033186 biolink:CellularComponent CAF-1 complex A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48. go.json chromatin assembly factor 1 complex http://purl.obolibrary.org/obo/GO_0033186 GO:0033174 biolink:CellularComponent chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits. go.json chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1) http://purl.obolibrary.org/obo/GO_0033174 GO:0033173 biolink:BiologicalProcess calcineurin-NFAT signaling cascade Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). go.json calcineurin-NFAT signaling pathway|calcineurin-NFAT signalling pathway http://purl.obolibrary.org/obo/GO_0033173 GO:0033172 biolink:CellularComponent gas vesicle shell The proteinaceous structure surrounding a gas vesicle. go.json gas vesicle membrane|gas vesicle wall http://purl.obolibrary.org/obo/GO_0033172 GO:0033171 biolink:MolecularActivity obsolete nucleoprotein filament-forming ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament. go.json nucleoprotein filament-forming ATPase activity True http://purl.obolibrary.org/obo/GO_0033171 GO:0033170 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033170 GO:0033179 biolink:CellularComponent proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. go.json http://purl.obolibrary.org/obo/GO_0033179 GO:0033178 biolink:CellularComponent proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. go.json http://purl.obolibrary.org/obo/GO_0033178 GO:0033177 biolink:CellularComponent proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. go.json http://purl.obolibrary.org/obo/GO_0033177 GO:0033176 biolink:CellularComponent proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. go.json hydrogen-translocating V-type ATPase complex http://purl.obolibrary.org/obo/GO_0033176 GO:0033175 biolink:CellularComponent chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins. go.json chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)|chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o) http://purl.obolibrary.org/obo/GO_0033175 GO:0033163 biolink:CellularComponent microneme membrane The lipid bilayer surrounding a microneme. go.json http://purl.obolibrary.org/obo/GO_0033163 GO:0033162 biolink:CellularComponent melanosome membrane The lipid bilayer surrounding a melanosome. go.json http://purl.obolibrary.org/obo/GO_0033162 GO:0033161 biolink:MolecularActivity mitogen-activated protein kinase kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase. go.json MAPKKKK binding http://purl.obolibrary.org/obo/GO_0033161 GO:0033160 biolink:BiologicalProcess obsolete positive regulation of protein import into nucleus, translocation OBSOLETE. Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. go.json positive regulation of protein import into cell nucleus, translocation True http://purl.obolibrary.org/obo/GO_0033160 GO:0033169 biolink:BiologicalProcess histone H3-K9 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone. go.json http://purl.obolibrary.org/obo/GO_0033169 gocheck_do_not_annotate GO:0033168 biolink:BiologicalProcess obsolete conversion of ds siRNA to ss siRNA involved in RNA interference OBSOLETE. The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference. go.json RNA interference, conversion of ds siRNA to ss siRNA True http://purl.obolibrary.org/obo/GO_0033168 GO:0033167 biolink:CellularComponent ARC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA. go.json argonaute siRNA chaperone complex http://purl.obolibrary.org/obo/GO_0033167 GO:0033166 biolink:CellularComponent hyaline layer A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms. go.json http://purl.obolibrary.org/obo/GO_0033166 GO:0033165 biolink:CellularComponent interphotoreceptor matrix A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance. go.json http://purl.obolibrary.org/obo/GO_0033165 GO:0033164 biolink:MolecularActivity glycolipid 1,6-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. EC:2.4.1.232|MetaCyc:2.4.1.232-RXN go.json GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity|GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity|GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity|glycolipid 6-alpha-mannosyltransferase activity|initiation-specific alpha-1,6-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0033164 GO:0033152 biolink:BiologicalProcess immunoglobulin V(D)J recombination The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined. go.json immunoglobulin V(D)J joining|immunoglobulin V-D-J joining|immunoglobulin V-D-J recombination|immunoglobulin V-J joining|immunoglobulin V-J recombination http://purl.obolibrary.org/obo/GO_0033152 GO:0033151 biolink:BiologicalProcess V(D)J recombination The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). Wikipedia:V(D)J_recombination go.json V(D)J joining|V-D-J joining|V-D-J recombination|V-J joining|V-J recombination http://purl.obolibrary.org/obo/GO_0033151 GO:0033150 biolink:CellularComponent cytoskeletal calyx A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins. go.json http://purl.obolibrary.org/obo/GO_0033150 GO:0033159 biolink:BiologicalProcess obsolete negative regulation of protein import into nucleus, translocation OBSOLETE. Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. go.json negative regulation of protein import into cell nucleus, translocation True http://purl.obolibrary.org/obo/GO_0033159 GO:0033158 biolink:BiologicalProcess obsolete regulation of protein import into nucleus, translocation OBSOLETE. Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. go.json regulation of protein import into cell nucleus, translocation True http://purl.obolibrary.org/obo/GO_0033158 GO:0033157 biolink:BiologicalProcess regulation of intracellular protein transport Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. go.json http://purl.obolibrary.org/obo/GO_0033157 GO:0033156 biolink:BiologicalProcess oligogalacturonide transport The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0033156 GO:0033155 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033155 GO:0033154 biolink:MolecularActivity ABC-type oligogalacturonide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in). TC:3.A.1.1.11 go.json ATP-dependent oligogalacturonide transmembrane transporter activity|ATPase-coupled oligogalacturonide transmembrane transporter activity|oligogalacturonide transmembrane transporter activity|oligogalacturonide transporting ATPase activity|oligogalacturonide-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033154 GO:0033153 biolink:BiologicalProcess T cell receptor V(D)J recombination The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). go.json T cell receptor V(D)J joining|T cell receptor V-D-J joining|T cell receptor V-D-J recombination|T cell receptor V-J joining|T cell receptor V-J recombination|T-cell receptor V(D)J recombination|TCR V(D)J recombination http://purl.obolibrary.org/obo/GO_0033153 GO:0008189 biolink:MolecularActivity obsolete apoptosis inhibitor activity OBSOLETE. The function held by products which directly block any step in the process of apoptosis. go.json apoptosis inhibitor activity True http://purl.obolibrary.org/obo/GO_0008189 GO:0008188 biolink:MolecularActivity neuropeptide receptor activity Combining with a neuropeptide to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0008188 GO:0008187 biolink:MolecularActivity poly-pyrimidine tract binding Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0008187 GO:0008186 biolink:MolecularActivity ATP-dependent activity, acting on RNA Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. Reactome:R-HSA-9770847|Reactome:R-HSA-9772351 go.json ATPase activity, acting on RNA|ATPase, acting on RNA|RNA-dependent ATPase activity|RNA-dependent adenosinetriphosphatase activity http://purl.obolibrary.org/obo/GO_0008186 GO:0033141 biolink:BiologicalProcess positive regulation of peptidyl-serine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json activation of serine phosphorylation of STAT3 protein|positive regulation of serine phosphorylation of STAT3 protein|up regulation of serine phosphorylation of STAT3 protein|up-regulation of serine phosphorylation of STAT3 protein|upregulation of serine phosphorylation of STAT3 protein http://purl.obolibrary.org/obo/GO_0033141 GO:0008196 biolink:MolecularActivity vitellogenin receptor activity Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis. go.json http://purl.obolibrary.org/obo/GO_0008196 GO:0008195 biolink:MolecularActivity phosphatidate phosphatase activity Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. EC:3.1.3.4|MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN|RHEA:27429|Reactome:R-HSA-1483203|Reactome:R-HSA-163688|Reactome:R-HSA-164056|Reactome:R-HSA-2029468|Reactome:R-HSA-390329|Reactome:R-HSA-5221130|Reactome:R-HSA-6797630|Reactome:R-HSA-75899 go.json 3-sn-phosphatidate phosphohydrolase activity|acid phosphatidyl phosphatase activity|phosphatic acid phosphatase activity|phosphatic acid phosphohydrolase activity|phosphatidate phosphohydrolase activity|phosphatidic acid phosphatase activity http://purl.obolibrary.org/obo/GO_0008195 GO:0033140 biolink:BiologicalProcess negative regulation of peptidyl-serine phosphorylation of STAT protein Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json down regulation of serine phosphorylation of STAT3 protein|down-regulation of serine phosphorylation of STAT3 protein|downregulation of serine phosphorylation of STAT3 protein|inhibition of serine phosphorylation of STAT3 protein|negative regulation of serine phosphorylation of STAT3 protein http://purl.obolibrary.org/obo/GO_0033140 GO:0008194 biolink:MolecularActivity UDP-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. Reactome:R-HSA-162730 go.json http://purl.obolibrary.org/obo/GO_0008194 GO:0008193 biolink:MolecularActivity tRNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. EC:2.7.7.79|RHEA:54564 go.json http://purl.obolibrary.org/obo/GO_0008193 GO:0008192 biolink:MolecularActivity RNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0008192 GO:0008191 biolink:MolecularActivity metalloendopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. go.json metalloprotease inhibitor|metalloproteinase inhibitor http://purl.obolibrary.org/obo/GO_0008191 GO:0008190 biolink:MolecularActivity eukaryotic initiation factor 4E binding Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. go.json eIF4E binding http://purl.obolibrary.org/obo/GO_0008190 GO:0033149 biolink:MolecularActivity FFAT motif binding Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. go.json http://purl.obolibrary.org/obo/GO_0033149 GO:0033148 biolink:BiologicalProcess positive regulation of intracellular estrogen receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. go.json positive regulation of estrogen receptor signaling pathway|positive regulation of estrogen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0033148 GO:0033147 biolink:BiologicalProcess negative regulation of intracellular estrogen receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. go.json negative regulation of estrogen receptor signaling pathway|negative regulation of estrogen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0033147 GO:0033146 biolink:BiologicalProcess regulation of intracellular estrogen receptor signaling pathway Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. go.json regulation of estrogen receptor signaling pathway|regulation of estrogen receptor signalling pathway http://purl.obolibrary.org/obo/GO_0033146 GO:0033145 biolink:BiologicalProcess positive regulation of intracellular steroid hormone receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. go.json positive regulation of steroid hormone receptor signaling pathway|positive regulation of steroid hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0033145 GO:0033144 biolink:BiologicalProcess negative regulation of intracellular steroid hormone receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. go.json negative regulation of steroid hormone receptor signaling pathway|negative regulation of steroid hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0033144 GO:0033143 biolink:BiologicalProcess regulation of intracellular steroid hormone receptor signaling pathway Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. go.json regulation of steroid hormone receptor signaling pathway|regulation of steroid hormone receptor signalling pathway http://purl.obolibrary.org/obo/GO_0033143 GO:0033142 biolink:MolecularActivity nuclear progesterone receptor binding Binding to a nuclear progesterone receptor. go.json progesterone receptor binding http://purl.obolibrary.org/obo/GO_0033142 GO:0033139 biolink:BiologicalProcess regulation of peptidyl-serine phosphorylation of STAT protein Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json regulation of serine phosphorylation of STAT3 protein http://purl.obolibrary.org/obo/GO_0033139 GO:0008199 biolink:MolecularActivity ferric iron binding Binding to a ferric iron ion, Fe(III). go.json http://purl.obolibrary.org/obo/GO_0008199 GO:0008198 biolink:MolecularActivity ferrous iron binding Binding to a ferrous iron ion, Fe(II). go.json http://purl.obolibrary.org/obo/GO_0008198 GO:0008197 biolink:MolecularActivity obsolete yolk protein OBSOLETE. (Was not defined before being made obsolete). go.json yolk protein True http://purl.obolibrary.org/obo/GO_0008197 GO:0033130 biolink:MolecularActivity acetylcholine receptor binding Binding to an acetylcholine receptor. go.json http://purl.obolibrary.org/obo/GO_0033130 GO:0033138 biolink:BiologicalProcess positive regulation of peptidyl-serine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. go.json http://purl.obolibrary.org/obo/GO_0033138 GO:0033137 biolink:BiologicalProcess negative regulation of peptidyl-serine phosphorylation Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. go.json http://purl.obolibrary.org/obo/GO_0033137 GO:0033136 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033136 GO:0033135 biolink:BiologicalProcess regulation of peptidyl-serine phosphorylation Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. go.json http://purl.obolibrary.org/obo/GO_0033135 GO:0033134 biolink:MolecularActivity ubiquitin activating enzyme binding Binding to a ubiquitin activating enzyme, any of the E1 proteins. go.json http://purl.obolibrary.org/obo/GO_0033134 GO:0033133 biolink:BiologicalProcess positive regulation of glucokinase activity Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. go.json glucokinase activator|stimulation of glucokinase activity|up regulation of glucokinase activity|up-regulation of glucokinase activity|upregulation of glucokinase activity http://purl.obolibrary.org/obo/GO_0033133 gocheck_do_not_annotate GO:0033132 biolink:BiologicalProcess negative regulation of glucokinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. go.json down regulation of glucokinase activity|down-regulation of glucokinase activity|downregulation of glucokinase activity|glucokinase inhibitor|inhibition of glucokinase activity http://purl.obolibrary.org/obo/GO_0033132 gocheck_do_not_annotate GO:0033131 biolink:BiologicalProcess regulation of glucokinase activity Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. go.json glucokinase regulator http://purl.obolibrary.org/obo/GO_0033131 gocheck_do_not_annotate GO:0047771 biolink:MolecularActivity carboxymethylhydantoinase activity Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H+. EC:3.5.2.4|KEGG_REACTION:R02284|MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN|RHEA:12028 go.json L-5-carboxymethylhydantoin amidohydrolase activity|hydantoin hydrolase activity http://purl.obolibrary.org/obo/GO_0047771 GO:0047770 biolink:MolecularActivity carboxylate reductase activity Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor. EC:1.2.99.6|MetaCyc:CARBOXYLATE-REDUCTASE-RXN go.json aldehyde:(acceptor) oxidoreductase activity|aldehyde:acceptor oxidoreductase activity|carboxylic acid reductase activity http://purl.obolibrary.org/obo/GO_0047770 GO:0047779 biolink:MolecularActivity citrate-CoA ligase activity Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H+ + phosphate. EC:6.2.1.18|KEGG_REACTION:R01322|MetaCyc:CITRATE--COA-LIGASE-RXN|RHEA:21472 go.json citrate thiokinase activity|citrate:CoA ligase (ADP-forming)|citrate:CoA ligase activity|citryl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0047779 GO:0047778 biolink:MolecularActivity [citrate-(pro-3S)-lyase] thiolesterase activity Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate. EC:3.1.2.16|MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN|RHEA:13657 go.json [citrate-(pro-3S)-lyase] thioesterase activity|citrate (pro-3S)-lyase thiolesterase activity|citrate lyase deacetylase activity|citrate-(pro-3S)-lyase thioesterase activity|citrate-(pro-3S)-lyase thiolesterase activity|citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity http://purl.obolibrary.org/obo/GO_0047778 GO:0047777 biolink:MolecularActivity (S)-citramalyl-CoA lyase activity Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate. EC:4.1.3.25|KEGG_REACTION:R00237|MetaCyc:CITRAMALYL-COA-LYASE-RXN|RHEA:22612 go.json (+)-CMA-CoA lyase activity|(3S)-citramalyl-CoA lyase activity|(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)|(3S)-citramalyl-CoA pyruvate-lyase activity|citramalyl coenzyme A lyase activity|citramalyl-CoA lyase activity http://purl.obolibrary.org/obo/GO_0047777 GO:0047776 biolink:MolecularActivity citramalate lyase activity Catalysis of the reaction: S-citramalate = acetate + pyruvate. EC:4.1.3.22|KEGG_REACTION:R00325|MetaCyc:CITRAMALATE-LYASE-RXN|RHEA:15545 go.json (+)-citramalate pyruvate-lyase activity|(3S)-citramalate pyruvate-lyase (acetate-forming)|(3S)-citramalate pyruvate-lyase activity|(S)-citramalate lyase activity|citramalate pyruvate lyase activity|citramalate pyruvate-lyase activity|citramalate synthetase activity|citramalic synthase activity|citramalic-condensing enzyme http://purl.obolibrary.org/obo/GO_0047776 GO:0047775 biolink:MolecularActivity citramalate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA. EC:2.8.3.11|MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN|RHEA:17621 go.json acetyl-CoA:citramalate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0047775 GO:0047774 biolink:MolecularActivity cis-2-enoyl-CoA reductase (NADPH) activity Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH. EC:1.3.1.37|MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN go.json NADPH-dependent cis-enoyl-CoA reductase activity|acyl-CoA:NADP+ cis-2-oxidoreductase activity|cis-2-enoyl-coenzyme A reductase activity|reductase, cis-2-enoyl coenzyme A http://purl.obolibrary.org/obo/GO_0047774 GO:0047773 biolink:MolecularActivity carnitinamidase activity Catalysis of the reaction: (R)-carnitinamide + H2O = (R)-carnitine + NH4. EC:3.5.1.73|KEGG_REACTION:R01922|MetaCyc:CARNITINAMIDASE-RXN|RHEA:17537 go.json L-carnitinamidase activity|L-carnitinamide amidohydrolase activity|L-carnitine amidase activity|carnitine amidase activity http://purl.obolibrary.org/obo/GO_0047773 GO:0047772 biolink:MolecularActivity carboxymethyloxysuccinate lyase activity Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate. EC:4.2.99.12|KEGG_REACTION:R01336|MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN|RHEA:12336 go.json carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)|carboxymethyloxysuccinate glycolate-lyase activity http://purl.obolibrary.org/obo/GO_0047772 GO:0072739 biolink:BiologicalProcess response to anisomycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072739 GO:0072738 biolink:BiologicalProcess cellular response to diamide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus. go.json cellular response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide http://purl.obolibrary.org/obo/GO_0072738 GO:0072737 biolink:BiologicalProcess response to diamide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus. go.json response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide http://purl.obolibrary.org/obo/GO_0072737 GO:0072736 biolink:BiologicalProcess cellular response to tert-butyl hydroperoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus. go.json cellular response to 2-methyl-prop-2-yl-hydroperoxide|cellular response to t-BOOH http://purl.obolibrary.org/obo/GO_0072736 GO:0072735 biolink:BiologicalProcess response to tert-butyl hydroperoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus. go.json response to 2-methyl-prop-2-yl-hydroperoxide|response to t-BOOH http://purl.obolibrary.org/obo/GO_0072735 GO:0072734 biolink:BiologicalProcess cellular response to staurosporine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. go.json http://purl.obolibrary.org/obo/GO_0072734 GO:0072733 biolink:BiologicalProcess response to staurosporine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. go.json http://purl.obolibrary.org/obo/GO_0072733 GO:0072732 biolink:BiologicalProcess cellular response to calcium ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions. go.json cellular response to calcium starvation http://purl.obolibrary.org/obo/GO_0072732 GO:0072731 biolink:BiologicalProcess cellular response to papulacandin B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus. go.json http://purl.obolibrary.org/obo/GO_0072731 GO:0072730 biolink:BiologicalProcess response to papulacandin B Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus. go.json http://purl.obolibrary.org/obo/GO_0072730 GO:0047782 biolink:MolecularActivity coniferin beta-glucosidase activity Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol. EC:3.2.1.126|MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN|RHEA:12252 go.json coniferin b-glucosidase activity|coniferin beta-D-glucosidase activity|coniferin-hydrolyzing beta-glucosidase activity http://purl.obolibrary.org/obo/GO_0047782 GO:0047781 biolink:MolecularActivity citrullinase activity Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine. EC:3.5.1.20|MetaCyc:CITRULLINASE-RXN|RHEA:11940 go.json L-citrulline 5-N-carbamoyldihydrolase activity|L-citrulline N5-carbamoyldihydrolase activity|citrulline hydrolase activity|citrulline ureidase activity http://purl.obolibrary.org/obo/GO_0047781 GO:0047780 biolink:MolecularActivity obsolete citrate dehydratase activity OBSOLETE. Catalysis of the reaction: citrate = cis-aconitate + H2O. go.json aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming)|citrate hydro-lyase (cis-aconitate-forming) activity|citrate hydro-lyase activity True http://purl.obolibrary.org/obo/GO_0047780 GO:0047789 biolink:MolecularActivity creatininase activity Catalysis of the reaction: creatinine + H2O = creatine. EC:3.5.2.10|KEGG_REACTION:R01884|MetaCyc:CREATININASE-RXN|RHEA:14533 go.json creatinine amidohydrolase activity|creatinine hydrolase http://purl.obolibrary.org/obo/GO_0047789 GO:0047788 biolink:MolecularActivity 2-coumarate reductase activity Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = trans-2-coumarate + H+ + NADH. EC:1.3.1.11|KEGG_REACTION:R03709|MetaCyc:COUMARATE-REDUCTASE-RXN|RHEA:21444 go.json 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity|coumarate reductase activity|melilotate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047788 GO:0047787 biolink:MolecularActivity delta4-3-oxosteroid 5beta-reductase activity Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. EC:1.3.1.3|MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN|MetaCyc:CORTISONE-BETA-REDUCTASE-RXN go.json 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity|3-oxo-Delta(4)-steroid 5-beta-reductase activity|3-oxo-delta4-steroid 5beta-reductase activity|4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity|5-beta-reductase activity|5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity|5beta-reductase activity|androstenedione 5-beta-reductase activity|androstenedione 5beta-reductase activity|cholestenone 5-beta-reductase activity|cholestenone 5b-reductase activity|cholestenone 5beta-reductase activity|cortisone 5-beta-reductase activity|cortisone 5beta-reductase activity|cortisone b-reductase activity|cortisone beta-reductase activity|cortisone delta(4)-5-beta-reductase activity|cortisone delta4-5beta-reductase activity|delta(4)-3-ketosteroid 5-beta-reductase activity|delta(4)-5-beta-reductase activity|delta(4)-hydrogenase activity|delta4-3-ketosteroid 5beta-reductase activity|delta4-3-oxosteroid 5-beta-reductase activity|delta4-5beta-reductase activity|delta4-hydrogenase activity|steroid 5-beta-reductase activity|steroid 5beta-reductase activity|testosterone 5-beta-reductase activity|testosterone 5beta-reductase activity http://purl.obolibrary.org/obo/GO_0047787 GO:0047786 biolink:MolecularActivity obsolete cortisone alpha-reductase activity OBSOLETE. Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP+ = cortisone + H+ + NADPH. KEGG_REACTION:R02892|MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN go.json 4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity|NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity|cortisone a-reductase activity|cortisone delta4-5alpha-reductase activity|delta4-3-ketosteroid reductase (5alpha)|delta4-3-oxosteroid-5alpha-reductase|delta4-5alpha-reductase activity|microsomal steroid reductase (5alpha) True http://purl.obolibrary.org/obo/GO_0047786 GO:0047785 biolink:MolecularActivity cortisol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H+. EC:2.8.2.18|KEGG_REACTION:R02839|MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN|RHEA:11884 go.json 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity|cortisol sulphotransferase activity|glucocorticoid sulfotransferase activity|glucocorticosteroid sulfotransferase activity http://purl.obolibrary.org/obo/GO_0047785 GO:0047784 biolink:MolecularActivity cortisol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate. EC:2.3.1.27|KEGG_REACTION:R02837|MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN|RHEA:17073 go.json acetyl-CoA:cortisol O-acetyltransferase activity|corticosteroid acetyltransferase activity|corticosteroid-21-O-acetyltransferase activity|cortisol acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047784 GO:0047783 biolink:MolecularActivity corticosterone 18-monooxygenase activity Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. EC:1.14.15.5|MetaCyc:RXN66-360|RHEA:11872 go.json corticosterone 18-hydroxylase activity|corticosterone methyl oxidase activity|corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating) http://purl.obolibrary.org/obo/GO_0047783 GO:0072729 biolink:BiologicalProcess cellular response to Gentian violet Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus. go.json cellular response to crystal violet|cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride http://purl.obolibrary.org/obo/GO_0072729 GO:0072728 biolink:BiologicalProcess response to Gentian violet Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus. go.json response to crystal violet|response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride http://purl.obolibrary.org/obo/GO_0072728 GO:0072727 biolink:BiologicalProcess obsolete cellular response to CCCP OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus. go.json cellular response to carbonyl cyanide m-chlorophenyl hydrazone True http://purl.obolibrary.org/obo/GO_0072727 GO:0072726 biolink:BiologicalProcess obsolete response to CCCP OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus. go.json response to carbonyl cyanide m-chlorophenyl hydrazone True http://purl.obolibrary.org/obo/GO_0072726 GO:0072725 biolink:BiologicalProcess cellular response to 4-nitroquinoline N-oxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus. go.json http://purl.obolibrary.org/obo/GO_0072725 GO:0072724 biolink:BiologicalProcess response to 4-nitroquinoline N-oxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus. go.json http://purl.obolibrary.org/obo/GO_0072724 GO:0072723 biolink:BiologicalProcess cellular response to amitrole Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus. go.json cellular response to 3-amino-1,2,4-triazole http://purl.obolibrary.org/obo/GO_0072723 GO:0072722 biolink:BiologicalProcess response to amitrole Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus. go.json response to 3-amino-1,2,4-triazole http://purl.obolibrary.org/obo/GO_0072722 GO:0072721 biolink:BiologicalProcess cellular response to dithiothreitol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. go.json cellular response to 1,4-dithiothreitol|cellular response to DTT http://purl.obolibrary.org/obo/GO_0072721 GO:0072720 biolink:BiologicalProcess response to dithiothreitol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. go.json response to 1,4-dithiothreitol|response to DTT http://purl.obolibrary.org/obo/GO_0072720 GO:0047793 biolink:MolecularActivity cycloeucalenol cycloisomerase activity Catalysis of the reaction: cycloeucalenol = obtusifoliol. EC:5.5.1.9|KEGG_REACTION:R03775|MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN|RHEA:22800 go.json cycloeucalenol lyase (cyclopropane-decyclizing)|cycloeucalenol--obtusifoliol isomerase activity|cycloeucalenol-obtusifoliol isomerase activity http://purl.obolibrary.org/obo/GO_0047793 GO:0047792 biolink:MolecularActivity cyanohydrin beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside. EC:2.4.1.85|RHEA:12853 go.json UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity|UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity|UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity|UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity|UGT85B1 activity|cyanohydrin b-glucosyltransferase activity|uridine diphosphoglucose-cyanohydrin glucosyltransferase activity|uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity|uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047792 GO:0047791 biolink:MolecularActivity cucurbitacin delta23-reductase activity Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+. EC:1.3.1.5|MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN go.json 23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity|NAD(P)H: cucurbitacin B delta23-oxidoreductase activity|cucurbitacin D23-reductase activity|cucurbitacin delta(23) reductase activity http://purl.obolibrary.org/obo/GO_0047791 GO:0047790 biolink:MolecularActivity creatinine deaminase activity Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3. EC:3.5.4.21|MetaCyc:CREATININE-DEAMINASE-RXN|RHEA:12681 go.json creatinine desiminase activity|creatinine hydrolase|creatinine iminohydrolase activity http://purl.obolibrary.org/obo/GO_0047790 GO:0047799 biolink:MolecularActivity cyclopentanone monooxygenase activity Catalysis of the reaction: cyclopentanone + H+ + NADPH + O2 = 5-valerolactone + H2O + NADP+. EC:1.14.13.16|KEGG_REACTION:R02554|MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN|RHEA:15737 go.json cyclopentanone 1,2-monooxygenase activity|cyclopentanone oxygenase activity|cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing) http://purl.obolibrary.org/obo/GO_0047799 GO:0047798 biolink:MolecularActivity cyclomaltodextrinase activity Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. EC:3.2.1.54|MetaCyc:CYCLOMALTODEXTRINASE-RXN|RHEA:23980 go.json cyclodextrinase activity|cycloheptaglucanase activity|cyclohexaglucanase activity|cyclomaltodextrin dextrin-hydrolase (decyclizing) http://purl.obolibrary.org/obo/GO_0047798 GO:0047797 biolink:MolecularActivity cyclohexanone dehydrogenase activity Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone. EC:1.3.99.14|KEGG_REACTION:R02234|MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN|RHEA:21780 go.json cyclohexanone:(acceptor) 2-oxidoreductase activity|cyclohexanone:acceptor 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047797 GO:0047796 biolink:MolecularActivity cyclohexane-1,3-dione hydrolase activity Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H+. EC:3.7.1.10|KEGG_REACTION:R03211|MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN|RHEA:16473 go.json 1,3-cyclohexanedione hydrolase activity|cyclohexane-1,3-dione acylhydrolase (decyclizing) http://purl.obolibrary.org/obo/GO_0047796 GO:0047795 biolink:MolecularActivity cyclohexane-1,2-diol dehydrogenase activity Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH. EC:1.1.1.174|MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN|RHEA:18141 go.json trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047795 GO:0047794 biolink:MolecularActivity cyclohexadienyl dehydrogenase activity Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2. EC:1.3.1.43|MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN|RHEA:12256 go.json L-arogenate:NAD(+) oxidoreductase activity|L-arogenate:NAD+ oxidoreductase (decarboxylating)|L-arogenate:NAD+ oxidoreductase activity|arogenate dehydrogenase activity|arogenic dehydrogenase activity|pretyrosine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047794 GO:0072759 biolink:BiologicalProcess cellular response to topoisomerase inhibitor Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus. go.json http://purl.obolibrary.org/obo/GO_0072759 GO:0072758 biolink:BiologicalProcess response to topoisomerase inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus. go.json http://purl.obolibrary.org/obo/GO_0072758 GO:0072757 biolink:BiologicalProcess cellular response to camptothecin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus. go.json cellular response to CPT http://purl.obolibrary.org/obo/GO_0072757 GO:0072756 biolink:BiologicalProcess cellular response to paraquat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. go.json http://purl.obolibrary.org/obo/GO_0072756 GO:0072755 biolink:BiologicalProcess obsolete cellular response to benomyl OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus. go.json True http://purl.obolibrary.org/obo/GO_0072755 GO:0072754 biolink:BiologicalProcess cellular response to purvalanol A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus. go.json http://purl.obolibrary.org/obo/GO_0072754 GO:0072753 biolink:BiologicalProcess cellular response to glutathione Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus. go.json http://purl.obolibrary.org/obo/GO_0072753 GO:0072752 biolink:BiologicalProcess cellular response to rapamycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072752 GO:0072751 biolink:BiologicalProcess cellular response to L-thialysine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus. go.json cellular response to thialysine http://purl.obolibrary.org/obo/GO_0072751 GO:0072750 biolink:BiologicalProcess cellular response to leptomycin B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus. go.json http://purl.obolibrary.org/obo/GO_0072750 GO:0072749 biolink:BiologicalProcess cellular response to cytochalasin B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus. go.json http://purl.obolibrary.org/obo/GO_0072749 GO:0072748 biolink:BiologicalProcess cellular response to tacrolimus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus (FK506) stimulus. go.json cellular response to FK506|cellular response to tacrolimus hydrate http://purl.obolibrary.org/obo/GO_0072748 GO:0072747 biolink:BiologicalProcess cellular response to chloramphenicol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus. go.json http://purl.obolibrary.org/obo/GO_0072747 GO:0072746 biolink:BiologicalProcess cellular response to tetracycline Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus. go.json http://purl.obolibrary.org/obo/GO_0072746 GO:0072745 biolink:BiologicalProcess cellular response to antimycin A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus. go.json http://purl.obolibrary.org/obo/GO_0072745 GO:0072744 biolink:BiologicalProcess cellular response to trichodermin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072744 GO:0072743 biolink:BiologicalProcess cellular response to erythromycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072743 GO:0072742 biolink:BiologicalProcess SAGA complex localization to transcription regulatory region Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene. go.json SAGA complex localization to promoter|SAGA complex recruitment http://purl.obolibrary.org/obo/GO_0072742 GO:0072741 biolink:BiologicalProcess protein localization to cell division site A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division. go.json protein localisation to cell division site http://purl.obolibrary.org/obo/GO_0072741 GO:0072740 biolink:BiologicalProcess cellular response to anisomycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072740 GO:0072760 biolink:BiologicalProcess cellular response to GW 7647 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus. go.json http://purl.obolibrary.org/obo/GO_0072760 GO:0072766 biolink:BiologicalProcess centromere clustering at the mitotic interphase nuclear envelope The process in which chromatin, or kinetochores are anchored to the nuclear envelope. This process involves the microtubule cytoskeleton, and nuclear tethering factors and is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. go.json centromere clustering at the mitotic nuclear envelope|centromere clustering at the nuclear periphery|centromere-SPB clustering|kinetochore clustering at SPB|kinetochore clustering at spindle pole body|kinetochore clustering at the old mitotic spindle pole body|kinetochore localization at spindle pole body|rabl configuration http://purl.obolibrary.org/obo/GO_0072766 GO:0072765 biolink:BiologicalProcess centromere localization A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location. go.json establishment and maintenance of kinetochore localization|kinetochore localisation|kinetochore localization http://purl.obolibrary.org/obo/GO_0072765 GO:0072764 biolink:BiologicalProcess cellular response to reversine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. go.json http://purl.obolibrary.org/obo/GO_0072764 GO:0072763 biolink:BiologicalProcess cellular response to hesperadin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus. go.json http://purl.obolibrary.org/obo/GO_0072763 GO:0072762 biolink:BiologicalProcess cellular response to carbendazim Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus. go.json http://purl.obolibrary.org/obo/GO_0072762 GO:0072761 biolink:BiologicalProcess cellular response to capsazepine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. go.json http://purl.obolibrary.org/obo/GO_0072761 GO:0008329 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008329 GO:0008328 biolink:CellularComponent ionotropic glutamate receptor complex A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. go.json http://purl.obolibrary.org/obo/GO_0008328 GO:0008327 biolink:MolecularActivity methyl-CpG binding Binding to a methylated cytosine/guanine dinucleotide. go.json http://purl.obolibrary.org/obo/GO_0008327 GO:0008326 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008326 GO:0008325 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008325 GO:0047933 biolink:MolecularActivity glucose-1,6-bisphosphate synthase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+. EC:2.7.1.106|KEGG_REACTION:R01660|MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN|RHEA:16769|Reactome:R-HSA-8955760 go.json 3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity|3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity|glucose 1,6-diphosphate synthase activity|glucose-1,6-bisphosphate synthetase activity http://purl.obolibrary.org/obo/GO_0047933 GO:0047932 biolink:MolecularActivity glucosamine N-acetyltransferase activity Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H+. EC:2.3.1.3|KEGG_REACTION:R01204|MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN|RHEA:21332 go.json acetyl-CoA:D-glucosamine N-acetyltransferase activity|glucosamine acetylase activity|glucosamine acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047932 GO:0008324 biolink:MolecularActivity monoatomic cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other. go.json cation transmembrane transporter activity|transmembrane cation transporter activity http://purl.obolibrary.org/obo/GO_0008324 GO:0047931 biolink:MolecularActivity glucosamine kinase activity Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate. EC:2.7.1.8|MetaCyc:GLUCOSAMINE-KINASE-RXN|RHEA:10948 go.json ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity|ATP:D-glucosamine phosphotransferase activity|aminodeoxyglucose kinase activity|glucosamine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0047931 GO:0008323 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008323 GO:0047930 biolink:MolecularActivity glucosaminate ammonia-lyase activity Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3. EC:4.3.1.9|MetaCyc:4.3.1.21-RXN|RHEA:12488 go.json 2-amino-2-deoxy-D-gluconate ammonia-lyase activity|2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity|D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)|D-glucosaminate ammonia-lyase activity|D-glucosaminate dehydratase activity|D-glucosaminic acid dehydrase activity|acetylenemonocarboxylic acid hydrase activity|aminodeoxygluconate ammonia-lyase activity|aminodeoxygluconate dehydratase activity|glucosaminic dehydrase activity http://purl.obolibrary.org/obo/GO_0047930 GO:0008322 biolink:MolecularActivity obsolete Pro-X carboxypeptidase activity OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid. go.json Pro-X carboxypeptidase activity True http://purl.obolibrary.org/obo/GO_0008322 GO:0008321 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008321 GO:0008320 biolink:MolecularActivity protein transmembrane transporter activity Enables the transfer of a protein from one side of a membrane to the other. Reactome:R-HSA-1268022|Reactome:R-HSA-1299475|Reactome:R-HSA-184269|Reactome:R-HSA-3149434|Reactome:R-HSA-5205661|Reactome:R-HSA-5210943|Reactome:R-HSA-5210947|Reactome:R-HSA-5228406|Reactome:R-HSA-5229111|Reactome:R-HSA-5244404|Reactome:R-HSA-5244428|Reactome:R-HSA-5244506|Reactome:R-HSA-5246514|Reactome:R-HSA-5250616|Reactome:R-HSA-5250884|Reactome:R-HSA-5250972|Reactome:R-HSA-5336420|Reactome:R-HSA-9636375|Reactome:R-HSA-9698930|Reactome:R-HSA-9698933 go.json protein channel activity http://purl.obolibrary.org/obo/GO_0008320 GO:0047939 biolink:MolecularActivity L-glucuronate reductase activity Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH. EC:1.1.1.19|KEGG_REACTION:R01481|MetaCyc:GLUCURONATE-REDUCTASE-RXN|RHEA:14909|Reactome:R-HSA-5661256 go.json D-glucuronate dehydrogenase activity|D-glucuronate reductase activity|NADP-L-gulonate dehydrogenase activity|TPN-L-gulonate dehydrogenase activity|aldehyde reductase II activity|glucuronate dehydrogenase activity|glucuronate reductase activity http://purl.obolibrary.org/obo/GO_0047939 GO:0047938 biolink:MolecularActivity glucose-6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. EC:5.1.3.15|MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN|RHEA:16249 go.json D-glucose-6-phosphate 1-epimerase activity|glucose-6 phosphate 1-epimerase activity http://purl.obolibrary.org/obo/GO_0047938 GO:0047937 biolink:MolecularActivity glucose-1-phosphate phosphodismutase activity Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate. EC:2.7.1.41|MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN|RHEA:16397 go.json D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity|glucose 1-phosphate transphosphorylase activity|phosphodismutase activity http://purl.obolibrary.org/obo/GO_0047937 GO:0047936 biolink:MolecularActivity glucose 1-dehydrogenase [NAD(P)] activity Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. EC:1.1.1.47|MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN go.json D-glucose dehydrogenase (NAD(P))|beta-D-glucose:NAD(P)+ 1-oxidoreductase activity|hexose phosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047936 GO:0047935 biolink:MolecularActivity glucose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH. EC:1.1.1.119|MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:14405 go.json D-glucose:NADP+ 1-oxidoreductase activity|NADP-dependent glucose dehydrogenase activity|NADP-linked aldohexose dehydrogenase activity|nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047935 GO:0047934 biolink:MolecularActivity glucose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH. EC:1.1.1.118|MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN|RHEA:14293 go.json D-aldohexose dehydrogenase activity|D-glucose:NAD oxidoreductase activity|D-glucose:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047934 GO:0008339 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008339 GO:0008338 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008338 GO:0008337 biolink:MolecularActivity obsolete selectin OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins. go.json selectin True http://purl.obolibrary.org/obo/GO_0008337 GO:0008336 biolink:MolecularActivity gamma-butyrobetaine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate. EC:1.14.11.1|KEGG_REACTION:R02397|MetaCyc:1.14.11.1-RXN|RHEA:24028|Reactome:R-HSA-71261 go.json 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|alpha-butyrobetaine hydroxylase activity|butyrobetaine hydroxylase activity|g-butyrobetaine dioxygenase activity|gamma-BBH activity|gamma-butyrobetaine hydroxylase activity|gamma-butyrobetaine,2-oxoglutarate dioxygenase activity http://purl.obolibrary.org/obo/GO_0008336 GO:0047944 biolink:MolecularActivity obsolete glutamate 1-kinase activity OBSOLETE. Catalysis of the reaction: L-glutamate + ATP = alpha-L-glutamyl phosphate + ADP + H+. go.json ATP:L-glutamate 1-phosphotransferase activity True http://purl.obolibrary.org/obo/GO_0047944 GO:0047943 biolink:MolecularActivity glutamate-methylamine ligase activity Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H+ + phosphate. EC:6.3.4.12|KEGG_REACTION:R01585|MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN|RHEA:17117 go.json L-glutamate:methylamine ligase (ADP-forming)|gamma-glutamylmethylamide synthetase activity http://purl.obolibrary.org/obo/GO_0047943 GO:0008335 biolink:BiologicalProcess female germline ring canal stabilization Maintenance of the structural integrity of the ring canals connecting the female germline cyst. go.json nurse cell ring canal stabilization|ovarian ring canal stabilization http://purl.obolibrary.org/obo/GO_0008335 GO:0047942 biolink:MolecularActivity glutamate-ethylamine ligase activity Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H+ + phosphate. EC:6.3.1.6|KEGG_REACTION:R02929|MetaCyc:RXN-12905|RHEA:20525 go.json L-glutamate:ethylamine ligase (ADP-forming)|N(5)-ethyl-L-glutamine synthetase activity|N5-ethyl-L-glutamine synthetase activity|N5-ethylglutamine synthetase activity|theanine synthetase activity http://purl.obolibrary.org/obo/GO_0047942 GO:0008334 biolink:BiologicalProcess histone mRNA metabolic process The chemical reactions and pathways involving an mRNA encoding a histone. go.json histone mRNA metabolism|stem-loop-containing histone mRNA 3'-end processing http://purl.obolibrary.org/obo/GO_0008334 GO:0008333 biolink:BiologicalProcess endosome to lysosome transport The directed movement of substances from endosomes to lysosomes. go.json http://purl.obolibrary.org/obo/GO_0008333 GO:0047941 biolink:MolecularActivity glucuronolactone reductase activity Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH. EC:1.1.1.20|KEGG_REACTION:R03183|MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN|RHEA:18925 go.json http://purl.obolibrary.org/obo/GO_0047941 GO:0047940 biolink:MolecularActivity glucuronokinase activity Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+. EC:2.7.1.43|KEGG_REACTION:R01476|MetaCyc:GLUCURONOKINASE-RXN|RHEA:17005 go.json ATP:D-glucuronate 1-phosphotransferase activity|glucurono-glucuronokinase activity|glucuronokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0047940 GO:0008332 biolink:MolecularActivity low voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. go.json T-type calcium channel|low voltage gated calcium channel activity|low voltage-dependent calcium channel activity http://purl.obolibrary.org/obo/GO_0008332 GO:0008331 biolink:MolecularActivity high voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. go.json L-type calcium channel|N-type calcium channel|P-type calcium channel|Q-type calcium channel|high voltage gated calcium channel activity|high voltage-dependent calcium channel activity http://purl.obolibrary.org/obo/GO_0008331 GO:0008330 biolink:MolecularActivity protein tyrosine/threonine phosphatase activity Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. go.json http://purl.obolibrary.org/obo/GO_0008330 GO:0047949 biolink:MolecularActivity obsolete glutarate-semialdehyde dehydrogenase (NAD+) activity OBSOLETE. Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH. go.json glutarate semialdehyde dehydrogenase (NAD+) activity True http://purl.obolibrary.org/obo/GO_0047949 GO:0047948 biolink:MolecularActivity glutarate-CoA ligase activity Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H+ + phosphate. EC:6.2.1.6|KEGG_REACTION:R02402|MetaCyc:GLUTARATE--COA-LIGASE-RXN|RHEA:14169 go.json glutarate:CoA ligase (ADP-forming)|glutaryl coenzyme A synthetase activity|glutaryl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0047948 GO:0047947 biolink:MolecularActivity glutamine N-phenylacetyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine. EC:2.3.1.14|MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN|RHEA:21844 go.json glutamine phenylacetyltransferase activity|phenylacetyl-CoA:L-glutamine N-acetyltransferase activity|phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity http://purl.obolibrary.org/obo/GO_0047947 GO:0047946 biolink:MolecularActivity glutamine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. EC:2.3.1.68|MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN|RHEA:18469 go.json acyl-CoA:L-glutamine N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047946 GO:0047945 biolink:MolecularActivity L-glutamine:pyruvate aminotransferase activity Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine. EC:2.6.1.15|KEGG_REACTION:R00576|MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN|RHEA:10400|Reactome:R-HSA-893616 go.json L-glutamine transaminase L|gamma-glutaminyltransferase activity|glutaminase II activity|glutamine transaminase L activity|glutamine transaminase activity|glutamine--oxo-acid transaminase activity|glutamine--pyruvate aminotransferase activity|glutamine-alpha-keto acid transamidase activity|glutamine-alpha-keto acid transaminase activity|glutamine-keto acid aminotransferase activity|glutamine-oxo acid aminotransferase activity|glutamine-pyruvate transaminase activity http://purl.obolibrary.org/obo/GO_0047945 GO:0008309 biolink:MolecularActivity double-stranded DNA exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. go.json double-stranded DNA specific exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0008309 GO:0008308 biolink:MolecularActivity voltage-gated monoatomic anion channel activity Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. Reactome:R-HSA-9012374 go.json voltage-dependent ion-selective channel activity|voltage-gated anion channel activity|voltage-gated ion-selective channel activity http://purl.obolibrary.org/obo/GO_0008308 GO:0008307 biolink:MolecularActivity structural constituent of muscle The action of a molecule that contributes to the structural integrity of a muscle fiber. go.json http://purl.obolibrary.org/obo/GO_0008307 GO:0008306 biolink:BiologicalProcess associative learning Learning by associating a stimulus (the cause) with a particular outcome (the effect). Wikipedia:Learning#Associative_learning go.json Pavlovian conditioning|classical conditioning|conditional learning|conditional response http://purl.obolibrary.org/obo/GO_0008306 GO:0008305 biolink:CellularComponent integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. go.json laminin receptor protein http://purl.obolibrary.org/obo/GO_0008305 GO:0008304 biolink:CellularComponent obsolete eukaryotic translation initiation factor 4 complex OBSOLETE. (Was not defined before being made obsolete). go.json eIF-4|eukaryotic translation initiation factor 4 complex True http://purl.obolibrary.org/obo/GO_0008304 GO:0008303 biolink:CellularComponent caspase complex A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes. go.json cysteine-type endopeptidase complex http://purl.obolibrary.org/obo/GO_0008303 GO:0047955 biolink:MolecularActivity glycerol dehydrogenase (acceptor) activity Catalysis of the reaction: A + glycerol = AH(2) + glycerone. EC:1.1.99.22|KEGG_REACTION:R01045|MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN|RHEA:17493 go.json glycerol:(acceptor) 1-oxidoreductase activity|glycerol:acceptor 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047955 GO:0008302 biolink:BiologicalProcess female germline ring canal formation, actin assembly Recruitment and organization of actin filaments in female germline ring canals. go.json nurse cell ring canal formation, actin assembly|ovarian ring canal formation, actin assembly|ring canal formation, actin assembly http://purl.obolibrary.org/obo/GO_0008302 GO:0047954 biolink:MolecularActivity glycerol-2-phosphatase activity Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate. EC:3.1.3.19|KEGG_REACTION:R01043|MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN|RHEA:13105 go.json 2-glycerophosphatase activity|beta-glycerophosphatase activity|beta-glycerophosphate phosphatase activity|glycerol-2-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047954 GO:0008301 biolink:MolecularActivity DNA binding, bending The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. go.json DNA bending activity|DNA bending involving DNA binding http://purl.obolibrary.org/obo/GO_0008301 GO:0047953 biolink:MolecularActivity glycerol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: glycerol + NADP+ = glycerone + H+ + NADPH. EC:1.1.1.156|KEGG_REACTION:R01039|MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN|RHEA:12753 go.json DHA oxidoreductase activity|dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|dihydroxyacetone reductase (NADPH)|dihydroxyacetone reductase activity|glycerol:NADP+ 2-oxidoreductase (glycerone-forming) http://purl.obolibrary.org/obo/GO_0047953 GO:0047952 biolink:MolecularActivity glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. EC:1.1.1.8|EC:1.1.1.94|KEGG_REACTION:R00842|KEGG_REACTION:R00844|MetaCyc:1.1.1.8-RXN|MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN|Reactome:R-HSA-75889 go.json L-alpha-glycerol phosphate dehydrogenase activity|L-alpha-glycerophosphate dehydrogenase activity|L-glycerol phosphate dehydrogenase activity|L-glycerol-3-phosphate:NAD(P) oxidoreductase activity|L-glycerophosphate dehydrogenase activity|NAD-L-glycerol-3-phosphate dehydrogenase activity|NAD-alpha-glycerophosphate dehydrogenase activity|NAD-dependent glycerol phosphate dehydrogenase activity|NAD-dependent glycerol-3-phosphate dehydrogenase activity|NAD-linked glycerol 3-phosphate dehydrogenase activity|NADH-dihydroxyacetone phosphate reductase activity|alpha-glycerol phosphate dehydrogenase (NAD) activity|alpha-glycerophosphate dehydrogenase (NAD) activity|glycerol 1-phosphate dehydrogenase activity|glycerol phosphate dehydrogenase (NAD) activity|glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity|glycerol-3-phosphate dehydrogenase (NAD(P)+) activity|glycerol-3-phosphate dehydrogenase (NAD) activity|glycerol-3-phosphate dehydrogenase [NAD+] activity|glycerol-3-phosphate dehydrogenase [NADP+] activity|glycerophosphate dehydrogenase (NAD) activity|hydroglycerophosphate dehydrogenase activity|sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047952 GO:0008300 biolink:BiologicalProcess isoprenoid catabolic process The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. go.json isoprenoid breakdown|isoprenoid catabolism|isoprenoid degradation|polyisoprenoid breakdown|polyisoprenoid catabolic process|polyisoprenoid catabolism|polyisoprenoid degradation|polyterpene catabolic process|polyterpene catabolism http://purl.obolibrary.org/obo/GO_0008300 GO:0047951 biolink:MolecularActivity glutathione thiolesterase activity Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+. EC:3.1.2.7|KEGG_REACTION:R00547|MetaCyc:GLUTATHIONE-THIOESTERASE-RXN|RHEA:22708 go.json S-acylglutathione hydrolase activity|citryl-glutathione thioesterhydrolase activity|glutathione thioesterase activity http://purl.obolibrary.org/obo/GO_0047951 GO:0047950 biolink:MolecularActivity glutathione oxidase activity Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2. EC:1.8.3.3|KEGG_REACTION:R00120|MetaCyc:GLUTATHIONE-OXIDASE-RXN|RHEA:24112 go.json glutathione:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047950 GO:0047959 biolink:MolecularActivity glycine dehydrogenase (cytochrome) activity Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c. EC:1.4.2.1|MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:16909 go.json glycine-cytochrome c reductase activity|glycine:ferricytochrome-c oxidoreductase (deaminating)|reductase, glycine-cytochrome c http://purl.obolibrary.org/obo/GO_0047959 GO:0047958 biolink:MolecularActivity glycine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate. EC:2.6.1.4|MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN|RHEA:14089 go.json L-glutamate:glyoxylate aminotransferase activity|glutamate-glyoxylate transaminase activity|glutamic-glyoxylic transaminase activity|glycine aminotransferase activity|glycine transaminase activity|glyoxylate-glutamate aminotransferase activity|glyoxylate-glutamic transaminase activity http://purl.obolibrary.org/obo/GO_0047958 GO:0047957 biolink:MolecularActivity 4'-methoxyisoflavone 2'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O. EC:1.14.14.89|MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN|RHEA:12388 go.json formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)|isoflavone 2'-monooxygenase activity http://purl.obolibrary.org/obo/GO_0047957 GO:0047956 biolink:MolecularActivity glycerol dehydrogenase [NADP+] activity Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH. EC:1.1.1.72|MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN|RHEA:23592 go.json glycerol dehydrogenase (NADP+) activity|glycerol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047956 GO:0008319 biolink:MolecularActivity obsolete prenyl protein specific endopeptidase activity OBSOLETE. (Was not defined before being made obsolete). go.json prenyl protein specific endopeptidase activity True http://purl.obolibrary.org/obo/GO_0008319 GO:0008318 biolink:MolecularActivity protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0008318 GO:0008317 biolink:MolecularActivity obsolete gurken receptor binding OBSOLETE. Binding to a gurken growth factor receptor. go.json gurken receptor ligand True http://purl.obolibrary.org/obo/GO_0008317 GO:0008316 biolink:MolecularActivity structural constituent of vitelline membrane The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0008316 GO:0008315 biolink:BiologicalProcess G2/MI transition of meiotic cell cycle The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I. go.json meiotic G2/MI phase transition|meiotic G2/MI transition|meiotic cell cycle G2/MI phase transition http://purl.obolibrary.org/obo/GO_0008315 GO:0047966 biolink:MolecularActivity glycosulfatase activity Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate. EC:3.1.6.3|KEGG_REACTION:R00534|MetaCyc:GLYCOSULFATASE-RXN|RHEA:19145 go.json glucosulfatase activity|glycosulphatase activity|sugar-sulfate sulfohydrolase activity http://purl.obolibrary.org/obo/GO_0047966 GO:0008314 biolink:BiologicalProcess obsolete gurken signaling pathway OBSOLETE. The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to a ligand Gurken. go.json gurken receptor signaling pathway|gurken receptor signalling pathway|gurken-activated signaling pathway|signaling by Gurken True http://purl.obolibrary.org/obo/GO_0008314 GO:0008313 biolink:MolecularActivity obsolete gurken-activated receptor activity OBSOLETE. Combining with the ligand Gurken to initiate a change in cell activity. go.json gurken receptor activity True http://purl.obolibrary.org/obo/GO_0008313 GO:0047965 biolink:MolecularActivity glycoprotein O-fatty-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein. EC:2.3.1.142|MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN go.json fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity|protein acyltransferase activity http://purl.obolibrary.org/obo/GO_0047965 GO:0047964 biolink:MolecularActivity glyoxylate reductase (NAD+) activity Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH. EC:1.1.1.26|MetaCyc:GLYCOLATE-REDUCTASE-RXN|RHEA:18229 go.json NADH-dependent glyoxylate reductase activity|glycolate reductase activity|glyoxylic acid reductase activity http://purl.obolibrary.org/obo/GO_0047964 GO:0008312 biolink:MolecularActivity 7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). go.json http://purl.obolibrary.org/obo/GO_0008312 GO:0047963 biolink:MolecularActivity glycine N-choloyltransferase activity Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate. EC:2.3.1.65|MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN|RHEA:14001 go.json BACAT activity|BAT activity|amino acid N-choloyltransferase activity|bile acid-CoA:amino acid N-acyltransferase activity|choloyl-CoA:glycine N-choloyltransferase activity|cholyl-CoA glycine-taurine N-acyltransferase activity|cholyl-CoA:taurine N-acyltransferase activity|glycine--taurine N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047963 GO:0008311 biolink:MolecularActivity double-stranded DNA 3'-5' DNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. EC:3.1.11.2|MetaCyc:3.1.11.2-RXN go.json double-stranded DNA 3'-5' exodeoxyribonuclease activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|exonuclease III activity|exoribonuclease III activity http://purl.obolibrary.org/obo/GO_0008311 GO:0047962 biolink:MolecularActivity glycine N-benzoyltransferase activity Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+. EC:2.3.1.71|KEGG_REACTION:R02452|MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN|RHEA:18493|Reactome:R-HSA-159566|Reactome:R-HSA-159574|Reactome:R-HSA-9750001 go.json benzoyl CoA-amino acid N-acyltransferase activity|benzoyl-CoA:glycine N-acyltransferase activity|benzoyl-CoA:glycine N-benzoyltransferase activity http://purl.obolibrary.org/obo/GO_0047962 GO:0008310 biolink:MolecularActivity single-stranded DNA 3'-5' DNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. EC:3.1.11.1|MetaCyc:3.1.11.1-RXN go.json exonuclease I activity|single-stranded DNA 3'-5' exodeoxyribonuclease activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|ssDNA-specific 3'-5' exodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0008310 GO:0047961 biolink:MolecularActivity glycine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. EC:2.3.1.13|MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN|RHEA:19869|Reactome:R-HSA-2534040 go.json acyl-CoA:glycine N-acyltransferase activity|glycine acyltransferase activity|glycine-N-acylase activity http://purl.obolibrary.org/obo/GO_0047961 GO:0047960 biolink:MolecularActivity glycine dehydrogenase activity Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH. EC:1.4.1.10|MetaCyc:GLYCINE-DEHYDROGENASE-RXN|RHEA:15721 go.json glycine:NAD+ oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0047960 GO:0047969 biolink:MolecularActivity glyoxylate oxidase activity Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate. EC:1.2.3.5|KEGG_REACTION:R00466|MetaCyc:GLYOXYLATE-OXIDASE-RXN|RHEA:14837|Reactome:R-HSA-389862 go.json glyoxylate:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047969 GO:0047968 biolink:MolecularActivity glyoxylate dehydrogenase (acylating) activity Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA. EC:1.2.1.17|KEGG_REACTION:R00468|MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN|RHEA:21024 go.json glyoxylate:NADP+ oxidoreductase (CoA-oxalylating) http://purl.obolibrary.org/obo/GO_0047968 GO:0047967 biolink:MolecularActivity glycyrrhizinate beta-glucuronidase activity Catalysis of the reaction: glycyrrhizate + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate. EC:3.2.1.128|KEGG_REACTION:R03906|MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN|RHEA:17369 go.json glycyrrhizin beta-hydrolase activity|glycyrrhizin hydrolase activity|glycyrrhizinate b-glucuronidase activity|glycyrrhizinate glucuronosylhydrolase activity|glycyrrhizinic acid hydrolase activity http://purl.obolibrary.org/obo/GO_0047967 GO:0047977 biolink:MolecularActivity hepoxilin-epoxide hydrolase activity Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. EC:3.3.2.7|MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN|RHEA:16665|Reactome:R-HSA-2161949 go.json (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity|hepoxilin A(3) hydrolase activity|hepoxilin A3 hydrolase activity|hepoxilin epoxide hydrolase activity|hepoxylin hydrolase activity http://purl.obolibrary.org/obo/GO_0047977 GO:0047976 biolink:MolecularActivity hamamelose kinase activity Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H+. EC:2.7.1.102|KEGG_REACTION:R03766|MetaCyc:HAMAMELOSE-KINASE-RXN|RHEA:22796 go.json ATP/hamamelose 2'-phosphotransferase activity|ATP:D-hamamelose 2'-phosphotransferase activity|hamamelose kinase (phosphorylating)|hamamelosekinase (ATP: hamamelose 2'-phosphotransferase) http://purl.obolibrary.org/obo/GO_0047976 GO:0047975 biolink:MolecularActivity guanosine phosphorylase activity Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate. EC:2.4.2.15|MetaCyc:RXN0-5199|RHEA:13233 go.json guanosine:phosphate D-ribosyltransferase activity|guanosine:phosphate alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0047975 GO:0047974 biolink:MolecularActivity guanosine deaminase activity Catalysis of the reaction: guanosine + H2O = xanthosine + NH3. EC:3.5.4.15|MetaCyc:GUANOSINE-DEAMINASE-RXN|RHEA:12861 go.json guanosine aminase activity|guanosine aminohydrolase activity http://purl.obolibrary.org/obo/GO_0047974 GO:0047973 biolink:MolecularActivity guanidinoacetate kinase activity Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H+ + phosphoguanidinoacetate. EC:2.7.3.1|KEGG_REACTION:R02575|MetaCyc:GUANIDOACETATE-KINASE-RXN|RHEA:14145 go.json ATP:guanidinoacetate N-phosphotransferase activity|glycocyamine kinase activity|guanidoacetate kinase activity http://purl.obolibrary.org/obo/GO_0047973 GO:0047972 biolink:MolecularActivity guanidinopropionase activity Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea. EC:3.5.3.17|KEGG_REACTION:R00913|MetaCyc:GUANIDINOPROPIONASE-RXN|RHEA:16029 go.json 3-guanidinopropanoate amidinopropionase activity|GPH|GPase activity http://purl.obolibrary.org/obo/GO_0047972 GO:0047971 biolink:MolecularActivity guanidinobutyrase activity Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea. EC:3.5.3.7|KEGG_REACTION:R01990|MetaCyc:GUANIDINOBUTYRASE-RXN|RHEA:19501 go.json 4-guanidinobutanoate amidinohydrolase activity|4-guanidinobutyrate amidinobutyrase activity|G-base activity|GBH|gamma-guanidinobutyrate amidinohydrolase activity|gamma-guanidobutyrase activity|guanidinobutyrate ureahydrolase activity http://purl.obolibrary.org/obo/GO_0047971 GO:0047970 biolink:MolecularActivity guanidinoacetase activity Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea. EC:3.5.3.2|KEGG_REACTION:R00775|MetaCyc:GUANIDINOACETASE-RXN|RHEA:23268 go.json glycocyaminase activity|guanidinoacetate amidinohydrolase activity http://purl.obolibrary.org/obo/GO_0047970 GO:0047979 biolink:MolecularActivity hexose oxidase activity Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202. EC:1.1.3.5 go.json D-hexose:oxygen 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047979 GO:0047978 biolink:MolecularActivity hexadecanol dehydrogenase activity Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH. EC:1.1.1.164|MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN|RHEA:22056 go.json hexadecanol:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047978 GO:0047980 biolink:MolecularActivity hippurate hydrolase activity Catalysis of the reaction: N-benzoylglycine + H2O = benzoate + glycine. EC:3.5.1.32|KEGG_REACTION:R01424|MetaCyc:HIPPURATE-HYDROLASE-RXN|RHEA:10424 go.json N-benzoylamino-acid amidohydrolase activity|benzoylglycine amidohydrolase activity|hippuricase activity http://purl.obolibrary.org/obo/GO_0047980 GO:0047988 biolink:MolecularActivity hydroxyacid-oxoacid transhydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. EC:1.1.99.24|MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN|Reactome:R-HSA-880002|Reactome:R-HSA-880033 go.json (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity|transhydrogenase, hydroxy acid-oxo acid http://purl.obolibrary.org/obo/GO_0047988 GO:0047987 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047987 GO:0047986 biolink:MolecularActivity hydrogen-sulfide S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate. EC:2.3.1.10|KEGG_REACTION:R01850|MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN|RHEA:16625 go.json acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity|hydrogen-sulfide acetyltransferase activity|hydrogen-sulphide S-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047986 GO:0047985 biolink:MolecularActivity hydrogen dehydrogenase activity Catalysis of the reaction: H2 + NAD+ = H+ + NADH. EC:1.12.1.2|MetaCyc:HYDROGEN-DEHYDROGENASE-RXN|RHEA:24636 go.json H(2):NAD(+) oxidoreductase activity|H2:NAD+ oxidoreductase activity|NAD-linked hydrogenase activity|bidirectional hydrogenase activity|hydrogen:NAD+ oxidoreductase activity|hydrogenase activity http://purl.obolibrary.org/obo/GO_0047985 GO:0047984 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047984 GO:0047983 biolink:MolecularActivity homoglutathione synthase activity Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate. EC:6.3.2.23|KEGG_REACTION:R02741|MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN|RHEA:17993 go.json beta-alanine specific hGSH synthetase activity|gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)|homoglutathione synthetase activity http://purl.obolibrary.org/obo/GO_0047983 GO:0047982 biolink:MolecularActivity homocysteine desulfhydrase activity Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. EC:4.4.1.2|MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN|RHEA:14501|Reactome:R-HSA-1614631 go.json L-homocysteine hydrogen-sulfide-lyase (deaminating)|L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)|homocysteine desulfurase activity http://purl.obolibrary.org/obo/GO_0047982 GO:0047981 biolink:MolecularActivity histidine N-acetyltransferase activity Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+. EC:2.3.1.33|KEGG_REACTION:R01160|MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN|RHEA:24596 go.json acetyl-CoA:L-histidine N-acetyltransferase activity|acetylhistidine synthetase activity|histidine acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047981 GO:0047989 biolink:MolecularActivity hydroxybutyrate-dimer hydrolase activity Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H2O = 2 (R)-3-hydroxybutanoate + H+. EC:3.1.1.22|KEGG_REACTION:R00048|MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN|RHEA:10172 go.json (R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity|D-(-)-3-hydroxybutyrate-dimer hydrolase activity http://purl.obolibrary.org/obo/GO_0047989 GO:0047991 biolink:MolecularActivity hydroxylamine oxidase activity Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite. EC:1.7.3.6|KEGG_REACTION:R00793|MetaCyc:HAONITRO-RXN|RHEA:19969 go.json HAO|hydroxylamine oxidoreductase|hydroxylamine:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047991 GO:0047990 biolink:MolecularActivity hydroxyglutamate decarboxylase activity Catalysis of the reaction: 3-hydroxy-L-glutamate + H+ = 4-amino-3-hydroxybutanoate + CO2. EC:4.1.1.16|KEGG_REACTION:R04135|MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN|RHEA:14073 go.json 3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)|3-hydroxy-L-glutamate 1-carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047990 GO:0047999 biolink:MolecularActivity hyponitrite reductase activity Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH. EC:1.7.1.5|KEGG_REACTION:R00023|MetaCyc:HYPONITRITE-REDUCTASE-RXN|RHEA:19337 go.json NADH2:hyponitrite oxidoreductase activity|NADH:hyponitrite oxidoreductase activity|hydroxylamine:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047999 GO:0047998 biolink:MolecularActivity hyoscyamine (6S)-dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate. EC:1.14.11.11|KEGG_REACTION:R03812|MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN|RHEA:12629 go.json L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)|hyoscyamine (6S)-hydroxylase activity|hyoscyamine 6-beta-hydroxylase activity|hyoscyamine 6-hydroxylase activity|hyoscyamine 6beta-dioxygenase activity|hyoscyamine 6beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0047998 GO:0047997 biolink:MolecularActivity hydroxypyruvate decarboxylase activity Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde. EC:4.1.1.40|KEGG_REACTION:R01393|MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN|RHEA:20561 go.json hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)|hydroxypyruvate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047997 GO:0047996 biolink:MolecularActivity hydroxyphytanate oxidase activity Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2. EC:1.1.3.27|KEGG_REACTION:R07151|MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN|RHEA:21680 go.json L-2-hydroxyphytanate:oxygen 2-oxidoreductase http://purl.obolibrary.org/obo/GO_0047996 GO:0047995 biolink:MolecularActivity hydroxyphenylpyruvate reductase activity Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. EC:1.1.1.237|MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN|RHEA:10780 go.json 4-hydroxyphenyllactate:NAD+ oxidoreductase activity|HPRP http://purl.obolibrary.org/obo/GO_0047995 GO:0047994 biolink:MolecularActivity hydroxymethylglutaryl-CoA hydrolase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+. EC:3.1.2.5|KEGG_REACTION:R02083|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN|RHEA:16305 go.json (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity|3-hydroxy-3-methylglutaryl-CoA hydrolase activity|beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity|beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity|hydroxymethylglutaryl coenzyme A deacylase activity|hydroxymethylglutaryl coenzyme A hydrolase activity http://purl.obolibrary.org/obo/GO_0047994 GO:0047993 biolink:MolecularActivity hydroxymalonate dehydrogenase activity Catalysis of the reaction: hydroxymalonate + NAD+ = H+ + NADH + oxomalonate. EC:1.1.1.167|KEGG_REACTION:R02969|MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN|RHEA:11284 go.json hydroxymalonate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047993 GO:0047992 biolink:MolecularActivity hydroxylysine kinase activity Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+. EC:2.7.1.81|KEGG_REACTION:R03378|MetaCyc:HYDROXYLYSINE-KINASE-RXN|RHEA:19049|Reactome:R-HSA-6788611 go.json GTP:5-hydroxy-L-lysine O-phosphotransferase activity|guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity|hydroxylysine kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0047992 GO:0033361 biolink:BiologicalProcess lysine biosynthetic process via diaminopimelate, dehydrogenase pathway The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step. MetaCyc:PWY-2942 go.json lysine anabolism via diaminopimelate, dehydrogenase pathway|lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway|lysine formation via diaminopimelate, dehydrogenase pathway|lysine synthesis via diaminopimelate, dehydrogenase pathway http://purl.obolibrary.org/obo/GO_0033361 GO:0033360 biolink:BiologicalProcess lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps. MetaCyc:PWY-2941 go.json lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate|lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate|lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate|lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate|lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate http://purl.obolibrary.org/obo/GO_0033360 GO:0033369 biolink:BiologicalProcess establishment of protein localization to mast cell secretory granule The directed movement of a protein to a location within a secretory granule in a mast cell. go.json establishment of protein localisation in mast cell secretory granule|establishment of protein localization in mast cell secretory granule http://purl.obolibrary.org/obo/GO_0033369 GO:0033368 biolink:BiologicalProcess protease localization to mast cell secretory granule Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell. go.json protease localisation in mast cell secretory granule|protease localization in mast cell secretory granule http://purl.obolibrary.org/obo/GO_0033368 GO:0033367 biolink:BiologicalProcess protein localization to mast cell secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell. go.json protein localisation in mast cell secretory granule|protein localization in mast cell secretory granule http://purl.obolibrary.org/obo/GO_0033367 GO:0033366 biolink:BiologicalProcess protein localization to secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule. go.json protein localisation in secretory granule|protein localization in secretory granule http://purl.obolibrary.org/obo/GO_0033366 GO:0033365 biolink:BiologicalProcess protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle. go.json protein localisation to organelle|protein localization in organelle http://purl.obolibrary.org/obo/GO_0033365 GO:0033364 biolink:BiologicalProcess mast cell secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. go.json mast cell secretory granule maturation|mast cell secretory granule organisation|mast cell secretory granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0033364 GO:0033363 biolink:BiologicalProcess secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. go.json secretory granule organisation|secretory granule organization and biogenesis http://purl.obolibrary.org/obo/GO_0033363 GO:0033362 biolink:BiologicalProcess lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps. MetaCyc:PWY-5097 go.json lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway|lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway|lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway|lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway http://purl.obolibrary.org/obo/GO_0033362 GO:0033359 biolink:BiologicalProcess lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps. MetaCyc:DAPLYSINESYN-PWY go.json lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate|lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate|lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate|lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate|lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate http://purl.obolibrary.org/obo/GO_0033359 GO:0033350 biolink:BiologicalProcess apiose biosynthetic process The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose. go.json apiose anabolism|apiose biosynthesis|apiose formation|apiose synthesis http://purl.obolibrary.org/obo/GO_0033350 GO:0033358 biolink:BiologicalProcess UDP-L-arabinose biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-63|MetaCyc:PWY-82 go.json UDP-L-arabinose anabolism|UDP-L-arabinose biosynthesis|UDP-L-arabinose formation|UDP-L-arabinose synthesis http://purl.obolibrary.org/obo/GO_0033358 GO:0033357 biolink:BiologicalProcess L-arabinose biosynthetic process The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose. go.json L-arabinose anabolism|L-arabinose biosynthesis|L-arabinose formation|L-arabinose synthesis http://purl.obolibrary.org/obo/GO_0033357 GO:0033356 biolink:BiologicalProcess UDP-L-arabinose metabolic process The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate. go.json UDP-L-arabinose metabolism http://purl.obolibrary.org/obo/GO_0033356 GO:0033355 biolink:BiologicalProcess ascorbate glutathione cycle A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH. MetaCyc:PWY-2261 go.json hydrogen peroxide detoxification http://purl.obolibrary.org/obo/GO_0033355 GO:0033354 biolink:BiologicalProcess chlorophyll cycle A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates. MetaCyc:PWY-5068 go.json http://purl.obolibrary.org/obo/GO_0033354 GO:0033353 biolink:BiologicalProcess S-adenosylmethionine cycle A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. MetaCyc:PWY-5041 go.json SAM cycle|activated methyl cycle http://purl.obolibrary.org/obo/GO_0033353 GO:0033352 biolink:BiologicalProcess UDP-D-apiose biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-4821|MetaCyc:PWY-5113 go.json UDP-D-apiose anabolism|UDP-D-apiose biosynthesis|UDP-D-apiose formation|UDP-D-apiose synthesis http://purl.obolibrary.org/obo/GO_0033352 GO:0033351 biolink:BiologicalProcess UDP-D-apiose metabolic process The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate. go.json UDP-D-apiose metabolism http://purl.obolibrary.org/obo/GO_0033351 GO:0033349 biolink:BiologicalProcess apiose metabolic process The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose. go.json apiose metabolism http://purl.obolibrary.org/obo/GO_0033349 GO:0033348 biolink:BiologicalProcess tetrose biosynthetic process The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule. go.json tetrose anabolism|tetrose biosynthesis|tetrose formation|tetrose synthesis http://purl.obolibrary.org/obo/GO_0033348 GO:0008389 biolink:MolecularActivity coumarin 7-hydroxylase activity Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. Reactome:R-HSA-211881|Reactome:R-HSA-76453 go.json cytochrome P450 CYP2A5 http://purl.obolibrary.org/obo/GO_0008389 GO:0008388 biolink:MolecularActivity testosterone 15-alpha-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O. go.json cytochrome P450 CYP2A4 http://purl.obolibrary.org/obo/GO_0008388 GO:0008387 biolink:MolecularActivity steroid 7-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O. go.json cytochrome P450 CYP2A12 http://purl.obolibrary.org/obo/GO_0008387 GO:0008386 biolink:MolecularActivity cholesterol monooxygenase (side-chain-cleaving) activity Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. EC:1.14.15.6|MetaCyc:1.14.15.6-RXN|RHEA:35739|Reactome:R-HSA-193054|Reactome:R-HSA-193065|Reactome:R-HSA-193101 go.json C27-side chain cleavage enzyme|Cyp11a1|cholesterol 20-22-desmolase activity|cholesterol C(20-22) desmolase activity|cholesterol C20-22 desmolase activity|cholesterol desmolase activity|cholesterol side-chain cleavage enzyme activity|cholesterol side-chain-cleaving enzyme activity|cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)|cytochrome P-450(scc) activity|cytochrome P-450scc|cytochrome p450(scc) activity|cytochrome p450scc|desmolase, steroid 20-22|enzymes, cholesterol side-chain-cleaving|steroid 20-22 desmolase activity|steroid 20-22-lyase activity http://purl.obolibrary.org/obo/GO_0008386 GO:0008385 biolink:CellularComponent IkappaB kinase complex A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. go.json IKK complex|heterotrimeric IKK complex|trimeric IKK complex http://purl.obolibrary.org/obo/GO_0008385 GO:0008384 biolink:MolecularActivity IkappaB kinase activity Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. EC:2.7.11.10|MetaCyc:2.7.11.10-RXN|RHEA:19073|Reactome:R-HSA-5684267|Reactome:R-HSA-5684275 go.json ATP:IkappaB protein phosphotransferase activity|CHUK|IKBKA|IKBKB|IKK|IKK-1|IKK-2|STK12|TANK-binding kinase 1 activity|TBK1|inhibitor of NF-kappaB kinase activity|inhibitor of NFkappaB kinase activity http://purl.obolibrary.org/obo/GO_0008384 GO:0008394 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008394 GO:0008393 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008393 GO:0008392 biolink:MolecularActivity arachidonic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. Reactome:R-HSA-211983 go.json cytochrome P450 CYP2J5|cytochrome P450 CYP2J6 http://purl.obolibrary.org/obo/GO_0008392 GO:0008391 biolink:MolecularActivity arachidonic acid monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. go.json cytochrome P450 CYP2B19 http://purl.obolibrary.org/obo/GO_0008391 GO:0008390 biolink:MolecularActivity testosterone 16-alpha-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O. go.json cytochrome P450 CYP2B10|cytochrome P450 CYP2B9|cytochrome P450 CYP2D10|cytochrome P450 CYP2D11|cytochrome P450 CYP2D9 http://purl.obolibrary.org/obo/GO_0008390 GO:0033347 biolink:BiologicalProcess tetrose metabolic process The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule. go.json tetrose metabolism http://purl.obolibrary.org/obo/GO_0033347 GO:0033346 biolink:BiologicalProcess asparagine catabolic process via 2-oxosuccinamate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate. MetaCyc:PWY-4002 go.json http://purl.obolibrary.org/obo/GO_0033346 GO:0033345 biolink:BiologicalProcess asparagine catabolic process via L-aspartate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate. MetaCyc:ASPARAGINE-DEG1-PWY go.json http://purl.obolibrary.org/obo/GO_0033345 GO:0033344 biolink:BiologicalProcess cholesterol efflux The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. go.json cholesterol export http://purl.obolibrary.org/obo/GO_0033344 GO:0033343 biolink:BiologicalProcess positive regulation of collagen binding Any process that activates or increases the frequency, rate or extent of collagen binding. go.json activation of collagen binding|stimulation of collagen binding|up regulation of collagen binding|up-regulation of collagen binding|upregulation of collagen binding http://purl.obolibrary.org/obo/GO_0033343 gocheck_do_not_annotate GO:0033342 biolink:BiologicalProcess negative regulation of collagen binding Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding. go.json down regulation of collagen binding|down-regulation of collagen binding|downregulation of collagen binding|inhibition of collagen binding http://purl.obolibrary.org/obo/GO_0033342 gocheck_do_not_annotate GO:0033341 biolink:BiologicalProcess regulation of collagen binding Any process that modulates the frequency, rate or extent of collagen binding. go.json http://purl.obolibrary.org/obo/GO_0033341 gocheck_do_not_annotate GO:0033340 biolink:BiologicalProcess pelvic fin development The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0033340 GO:0033339 biolink:BiologicalProcess pectoral fin development The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0033339 GO:0033338 biolink:BiologicalProcess medial fin development The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure. go.json median fin development http://purl.obolibrary.org/obo/GO_0033338 GO:0033337 biolink:BiologicalProcess dorsal fin development The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0033337 GO:0008399 biolink:MolecularActivity naphthalene hydroxylase activity Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide. go.json cytochrome P450 CYP2F2 http://purl.obolibrary.org/obo/GO_0008399 GO:0008398 biolink:MolecularActivity sterol 14-demethylase activity Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.154|MetaCyc:1.14.13.70-RXN|RHEA:54028|Reactome:R-HSA-194678 go.json cytochrome P450 51 activity|cytochrome P450 CYP51|lanosterol 14-alpha-demethylase activity|lanosterol 14-demethylase activity|lanosterol 14alpha-demethylase activity|obtusufoliol 14-demethylase activity|sterol 14-alpha-demethylase activity|sterol 14alpha-demethylase activity http://purl.obolibrary.org/obo/GO_0008398 GO:0008397 biolink:MolecularActivity sterol 12-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. EC:1.14.14.139 go.json cytochrome P450 CYP8B1 http://purl.obolibrary.org/obo/GO_0008397 GO:0008396 biolink:MolecularActivity oxysterol 7-alpha-hydroxylase activity Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. Reactome:R-HSA-191972|Reactome:R-HSA-192065|Reactome:R-HSA-192178|Reactome:R-HSA-5602885 go.json cytochrome P450 CYP7B1 http://purl.obolibrary.org/obo/GO_0008396 GO:0008395 biolink:MolecularActivity steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. RHEA:43836|Reactome:R-HSA-191983|Reactome:R-HSA-191999|Reactome:R-HSA-192042|Reactome:R-HSA-192054|Reactome:R-HSA-192123|Reactome:R-HSA-193060|Reactome:R-HSA-193143|Reactome:R-HSA-193393|Reactome:R-HSA-193460|Reactome:R-HSA-193497|Reactome:R-HSA-193713|Reactome:R-HSA-193719|Reactome:R-HSA-193737|Reactome:R-HSA-193780|Reactome:R-HSA-193787|Reactome:R-HSA-193792|Reactome:R-HSA-193965|Reactome:R-HSA-193995|Reactome:R-HSA-5601849|Reactome:R-HSA-5602170|Reactome:R-HSA-6785244|Reactome:R-HSA-6785245|Reactome:R-HSA-9035960|Reactome:R-HSA-9758674 go.json cytochrome P450 CYP2G1|olfactory-specific steroid hydroxylase activity http://purl.obolibrary.org/obo/GO_0008395 GO:0033336 biolink:BiologicalProcess caudal fin development The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0033336 GO:0033335 biolink:BiologicalProcess anal fin development The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0033335 GO:0033334 biolink:BiologicalProcess fin morphogenesis The process in which the anatomical structures of a fin are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0033334 GO:0033333 biolink:BiologicalProcess fin development The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0033333 GO:0033332 biolink:BiologicalProcess ent-kaurene biosynthetic process The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins. MetaCyc:PWY-5032|MetaCyc:PWY-5035 go.json ent-kaurene anabolism|ent-kaurene biosynthesis|ent-kaurene formation|ent-kaurene synthesis http://purl.obolibrary.org/obo/GO_0033332 GO:0033331 biolink:BiologicalProcess ent-kaurene metabolic process The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins. go.json ent-kaurene metabolism http://purl.obolibrary.org/obo/GO_0033331 GO:0033330 biolink:BiologicalProcess kaempferol O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. MetaCyc:PWY-5320 go.json kaempferol O-glucoside anabolism|kaempferol O-glucoside biosynthesis|kaempferol O-glucoside formation|kaempferol O-glucoside synthesit http://purl.obolibrary.org/obo/GO_0033330 GO:0033329 biolink:BiologicalProcess kaempferol O-glucoside metabolic process The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol. go.json kaempferol O-glucoside metabolism http://purl.obolibrary.org/obo/GO_0033329 GO:0033328 biolink:MolecularActivity peroxisome membrane targeting sequence binding Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane. go.json PMP targeting signal (mPTS) binding|PMP targeting signal binding|mPTS binding|peroxisomal membrane protein (PMP) targeting signal (mPTS) binding http://purl.obolibrary.org/obo/GO_0033328 GO:0033327 biolink:BiologicalProcess Leydig cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. go.json http://purl.obolibrary.org/obo/GO_0033327 GO:0033326 biolink:BiologicalProcess cerebrospinal fluid secretion The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces. go.json CSF secretion http://purl.obolibrary.org/obo/GO_0033326 GO:0008369 biolink:MolecularActivity obsolete molecular function OBSOLETE. These are terms that have been removed from the active function ontology. go.json True http://purl.obolibrary.org/obo/GO_0008369 GO:0008368 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008368 GO:0008367 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008367 GO:0008366 biolink:BiologicalProcess axon ensheathment Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. go.json cellular axon ensheathment|cellular nerve ensheathment|nerve ensheathment http://purl.obolibrary.org/obo/GO_0008366 GO:0008365 biolink:BiologicalProcess adult chitin-based cuticle development Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster. go.json adult chitin-based cuticle anabolism|adult chitin-based cuticle biosynthetic process|adult chitin-based cuticle formation|adult chitin-based cuticle synthesis|adult cuticle anabolism|adult cuticle biosynthetic process|adult cuticle formation|adult cuticle synthesis http://purl.obolibrary.org/obo/GO_0008365 GO:0008364 biolink:BiologicalProcess pupal chitin-based cuticle development Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster. go.json pupal cuticle anabolism|pupal cuticle formation|pupal cuticle synthesis http://purl.obolibrary.org/obo/GO_0008364 GO:0008363 biolink:BiologicalProcess larval chitin-based cuticle development Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster. go.json larval cuticle anabolism|larval cuticle biosynthetic process|larval cuticle formation|larval cuticle synthesis http://purl.obolibrary.org/obo/GO_0008363 GO:0008362 biolink:BiologicalProcess chitin-based embryonic cuticle biosynthetic process Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster. go.json embryonic cuticle anabolism|embryonic cuticle biosynthetic process|embryonic cuticle formation|embryonic cuticle synthesis http://purl.obolibrary.org/obo/GO_0008362 GO:0008372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008372 GO:0008371 biolink:BiologicalProcess obsolete biological process OBSOLETE. These are terms that have been removed from the active process ontology. go.json True http://purl.obolibrary.org/obo/GO_0008371 GO:0008370 biolink:CellularComponent obsolete cellular component OBSOLETE. These are terms that have been removed from the active component ontology. go.json True http://purl.obolibrary.org/obo/GO_0008370 GO:0033325 biolink:BiologicalProcess choline biosynthetic process via phosphoryl-ethanolamine The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine. MetaCyc:PWY-3385|MetaCyc:PWY-4762 go.json choline anabolism via phosphoryl-ethanolamine|choline biosynthesis via phosphoryl-ethanolamine|choline formation via phosphoryl-ethanolamine|choline synthesis via phosphoryl-ethanolamine http://purl.obolibrary.org/obo/GO_0033325 GO:0033324 biolink:BiologicalProcess choline biosynthetic process via N-monomethylethanolamine The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine. MetaCyc:PWY-3542|MetaCyc:PWY-4762 go.json choline anabolism via N-monomethylethanolamine|choline biosynthesis via N-monomethylethanolamine|choline formation via N-monomethylethanolamine|choline synthesis via N-monomethylethanolamine http://purl.obolibrary.org/obo/GO_0033324 GO:0033323 biolink:BiologicalProcess choline biosynthetic process via CDP-choline The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline. MetaCyc:PWY-3561|MetaCyc:PWY-4762 go.json choline anabolism via CDP-choline|choline biosynthesis via CDP-choline|choline formation via CDP-choline|choline synthesis via CDP-choline http://purl.obolibrary.org/obo/GO_0033323 GO:0033322 biolink:BiologicalProcess homomethionine biosynthetic process The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation. MetaCyc:PWY-1186 go.json homomethionine anabolism|homomethionine biosynthesis|homomethionine formation|homomethionine synthesis http://purl.obolibrary.org/obo/GO_0033322 GO:0033321 biolink:BiologicalProcess homomethionine metabolic process The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation. go.json homomethionine metabolism http://purl.obolibrary.org/obo/GO_0033321 GO:0033320 biolink:BiologicalProcess UDP-D-xylose biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-4821 go.json UDP-D-xylose anabolism|UDP-D-xylose biosynthesis|UDP-D-xylose formation|UDP-D-xylose synthesis http://purl.obolibrary.org/obo/GO_0033320 GO:0033319 biolink:BiologicalProcess UDP-D-xylose metabolic process The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate. go.json UDP-D-xylose metabolism http://purl.obolibrary.org/obo/GO_0033319 GO:0033318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033318 GO:0033317 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033317 GO:0033316 biolink:BiologicalProcess meiotic spindle assembly checkpoint signaling A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle. go.json meiotic spindle assembly checkpoint|signal transduction involved in meiotic spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_0033316 GO:0033315 biolink:BiologicalProcess meiotic G2/MI DNA replication checkpoint signaling A signal transduction process that controls the G2/M1 transition of the meiotic cell cycle and prevents the initiation of nuclear division until DNA replication is complete. go.json meiotic G2/MI DNA replication checkpoint|meiotic cell cycle DNA replication checkpoint|signal transduction involved in meiotic DNA replication checkpoint http://purl.obolibrary.org/obo/GO_0033315 GO:0047900 biolink:MolecularActivity formate kinase activity Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H+. EC:2.7.2.6|KEGG_REACTION:R00518|MetaCyc:FORMATE-KINASE-RXN|RHEA:16009 go.json ATP:formate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047900 GO:0008379 biolink:MolecularActivity thioredoxin peroxidase activity Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O. MetaCyc:RXN0-267|RHEA:63528|Reactome:R-HSA-2161612|Reactome:R-HSA-3322995|Reactome:R-HSA-3341343|Reactome:R-HSA-3697882|Reactome:R-HSA-3697894 go.json TPx activity|TrxPx activity|thiol peroxidase activity http://purl.obolibrary.org/obo/GO_0008379 GO:0008378 biolink:MolecularActivity galactosyltransferase activity Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. Reactome:R-HSA-1964501 go.json http://purl.obolibrary.org/obo/GO_0008378 GO:0008377 biolink:BiologicalProcess light-induced release of internally sequestered calcium ion The process in which the detection of light triggers the release of internally sequestered calcium ions. go.json light-induced release of calcium from internal store|light-induced release of internally sequestered calcium ion (Ca2+)|light-induced release of internally stored calcium ion (Ca2+) http://purl.obolibrary.org/obo/GO_0008377 GO:0008376 biolink:MolecularActivity acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. Reactome:R-HSA-8855954|Reactome:R-HSA-8931648|Reactome:R-HSA-9605700 go.json GalNAc transferase activity http://purl.obolibrary.org/obo/GO_0008376 GO:0008375 biolink:MolecularActivity acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. Reactome:R-HSA-5694487|Reactome:R-HSA-8879117|Reactome:R-HSA-9683648|Reactome:R-HSA-9694656 go.json GlcNAc transferase activity http://purl.obolibrary.org/obo/GO_0008375 GO:0008374 biolink:MolecularActivity O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. Reactome:R-HSA-1482775|Reactome:R-HSA-1482781|Reactome:R-HSA-1482850|Reactome:R-HSA-1482861|Reactome:R-HSA-1482867|Reactome:R-HSA-162683|Reactome:R-HSA-3238694|Reactome:R-HSA-422017|Reactome:R-HSA-422104|Reactome:R-HSA-5358343|Reactome:R-HSA-5483229 go.json http://purl.obolibrary.org/obo/GO_0008374 GO:0008373 biolink:MolecularActivity sialyltransferase activity Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. EC:2.4.3.-|Reactome:R-HSA-9683769|Reactome:R-HSA-9694718|Reactome:R-HSA-9697018|Reactome:R-HSA-981814|Wikipedia:Sialyltransferase go.json http://purl.obolibrary.org/obo/GO_0008373 GO:0047908 biolink:MolecularActivity fusarinine-C ornithinesterase activity Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol. EC:3.1.1.48|MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN|RHEA:20165 go.json 5-N-acyl-L-ornithine-ester hydrolase activity|N5-acyl-L-ornithine-ester hydrolase activity|ornithine esterase activity http://purl.obolibrary.org/obo/GO_0047908 GO:0008383 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008383 GO:0047907 biolink:MolecularActivity furylfuramide isomerase activity Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide. EC:5.2.1.6|KEGG_REACTION:R04538|MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN|RHEA:21848 go.json 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity http://purl.obolibrary.org/obo/GO_0047907 GO:0008382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008382 GO:0008381 biolink:MolecularActivity mechanosensitive monoatomic ion channel activity Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. TC:1.A.23.2.1 go.json mechanically gated channel activity|mechanically-gated channel activity|mechanically-gated ion channel activity|mechanosensitive ion channel activity http://purl.obolibrary.org/obo/GO_0008381 GO:0047906 biolink:MolecularActivity fucosterol-epoxide lyase activity Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol. EC:4.1.2.33|KEGG_REACTION:R03723|MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN|RHEA:10884 go.json (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)|(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0047906 GO:0047905 biolink:MolecularActivity fructose-6-phosphate phosphoketolase activity Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. EC:4.1.2.22|MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN|RHEA:12196 go.json D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)|D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity http://purl.obolibrary.org/obo/GO_0047905 GO:0008380 biolink:BiologicalProcess RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. Wikipedia:RNA_splicing go.json pre-mRNA splicing factor activity http://purl.obolibrary.org/obo/GO_0008380 goslim_yeast GO:0047904 biolink:MolecularActivity fructose 5-dehydrogenase activity Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2). EC:1.1.99.11|KEGG_REACTION:R00873|MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN|RHEA:22304 go.json D-fructose dehydrogenase activity|D-fructose:(acceptor) 5-oxidoreductase activity|D-fructose:acceptor 5-oxidoreductase activity|fructose 5-dehydrogenase (acceptor) http://purl.obolibrary.org/obo/GO_0047904 GO:0047903 biolink:MolecularActivity fructose 5-dehydrogenase (NADP+) activity Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH. EC:1.1.1.124|MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN|RHEA:14069 go.json 5-keto-D-fructose reductase (NADP+)|5-ketofructose reductase (NADP(+)) activity|5-ketofructose reductase (NADP)|5-ketofructose reductase (NADP+) activity|D-(-)fructose:(NADP+) 5-oxidoreductase activity|D-fructose:NADP+ 5-oxidoreductase activity|fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047903 GO:0047902 biolink:MolecularActivity formylaspartate deformylase activity Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate. EC:3.5.1.8|MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN|RHEA:22040 go.json N-formyl-L-aspartate amidohydrolase activity|formylaspartic formylase (formylase I, formylase II) http://purl.obolibrary.org/obo/GO_0047902 GO:0047901 biolink:MolecularActivity formyl-CoA hydrolase activity Catalysis of the reaction: formyl-CoA + H2O = CoA + formate + H+. EC:3.1.2.10|KEGG_REACTION:R00521|MetaCyc:FORMYL-COA-HYDROLASE-RXN|RHEA:19741 go.json formyl coenzyme A hydrolase activity http://purl.obolibrary.org/obo/GO_0047901 GO:0033314 biolink:BiologicalProcess mitotic DNA replication checkpoint signaling A signal transduction process that contributes to a mitotic DNA replication checkpoint. go.json S-M DNA replication checkpoint|S-M checkpoint|S-phase checkpoint|mitotic DNA replication checkpoint|mitotic cell cycle DNA replication checkpoint|signal transduction involved in S-M checkpoint|signal transduction involved in mitotic DNA replication checkpoint|signal transduction involved in mitotic G2/M transition decatenation checkpoint http://purl.obolibrary.org/obo/GO_0033314 GO:0033313 biolink:BiologicalProcess meiotic cell cycle checkpoint signaling A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage. go.json meiotic cell cycle checkpoint|signal transduction involved in meiotic cell cycle checkpoint http://purl.obolibrary.org/obo/GO_0033313 GO:0033312 biolink:BiologicalProcess chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a. MetaCyc:PWY-5064 go.json chlorophyll a anabolism via geranylgeranyl-chlorophyll a|chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a|chlorophyll a formation via geranylgeranyl-chlorophyll a|chlorophyll a synthesis via geranylgeranyl-chlorophyll a http://purl.obolibrary.org/obo/GO_0033312 GO:0033311 biolink:BiologicalProcess chlorophyll a biosynthetic process via phytyl diphosphate The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate. MetaCyc:PWY-5086 go.json chlorophyll a anabolism via phytyl diphosphate|chlorophyll a biosynthesis via phytyl diphosphate|chlorophyll a biosynthetic process via phytyl-PP|chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP|chlorophyll a synthesis via phytyl diphosphate http://purl.obolibrary.org/obo/GO_0033311 GO:0033310 biolink:BiologicalProcess chlorophyll a catabolic process The chemical reactions and pathways leading to the breakdown of chlorophyll a. MetaCyc:PWY-5086|MetaCyc:PWY-5098 go.json chlorophyll a breakdown|chlorophyll a catabolism|chlorophyll a degradation http://purl.obolibrary.org/obo/GO_0033310 GO:0047909 biolink:MolecularActivity galactolipid O-acyltransferase activity Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol. EC:2.3.1.134|MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN go.json galactolipid:galactolipid acyltransferase activity|mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity http://purl.obolibrary.org/obo/GO_0047909 GO:0033309 biolink:CellularComponent SBF transcription complex A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p. go.json SBF complex http://purl.obolibrary.org/obo/GO_0033309 GO:0033308 biolink:BiologicalProcess hydroxyectoine transport The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0033308 GO:0033307 biolink:BiologicalProcess phytol salvage A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis. MetaCyc:PWY-5107 go.json phytol salvage pathway http://purl.obolibrary.org/obo/GO_0033307 GO:0033306 biolink:BiologicalProcess phytol metabolic process The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol. go.json phytol metabolism http://purl.obolibrary.org/obo/GO_0033306 GO:0033305 biolink:BiologicalProcess chlorophyll a biosynthetic process The chemical reactions and pathways leading to the formation of chlorophyll a. go.json chlorophyll a anabolism|chlorophyll a biosynthesis|chlorophyll a formation|chlorophyll a synthesis http://purl.obolibrary.org/obo/GO_0033305 GO:0008349 biolink:MolecularActivity MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. Reactome:R-HSA-177692|Reactome:R-HSA-936991|Reactome:R-HSA-9645442 go.json MAP4K activity|MAPKKKK http://purl.obolibrary.org/obo/GO_0008349 GO:0008348 biolink:BiologicalProcess negative regulation of antimicrobial humoral response Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response. go.json attenuation of antimicrobial humoral response|down regulation of antimicrobial humoral response|down-regulation of antimicrobial humoral response|downregulation of antimicrobial humoral response|inhibition of antimicrobial humoral response http://purl.obolibrary.org/obo/GO_0008348 GO:0033304 biolink:BiologicalProcess chlorophyll a metabolic process The chemical reactions and pathways involving chlorophyll a. go.json chlorophyll a metabolism http://purl.obolibrary.org/obo/GO_0033304 GO:0047911 biolink:MolecularActivity galacturan 1,4-alpha-galacturonidase activity Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate. EC:3.2.1.67|MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN|RHEA:14117 go.json exo-D-galacturonanase activity|exo-D-galacturonase activity|exo-polygalacturonase activity|exopoly-D-galacturonase activity|exopolygalacturonase activity|galacturan alpha-1,4-galacturonidase activity|poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity|poly(galacturonate) hydrolase activity http://purl.obolibrary.org/obo/GO_0047911 GO:0008347 biolink:BiologicalProcess glial cell migration The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. go.json glia cell migration http://purl.obolibrary.org/obo/GO_0008347 GO:0047910 biolink:MolecularActivity galactose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH. EC:1.1.1.120|MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:18625 go.json D-galactose dehydrogenase (NADP+)|D-galactose:NADP+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047910 GO:0008346 biolink:BiologicalProcess larval walking behavior The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. go.json larval walking behaviour http://purl.obolibrary.org/obo/GO_0008346 GO:0008345 biolink:BiologicalProcess larval locomotory behavior Locomotory behavior in a larval (immature) organism. go.json larval locomotory behaviour http://purl.obolibrary.org/obo/GO_0008345 GO:0008344 biolink:BiologicalProcess adult locomotory behavior Locomotory behavior in a fully developed and mature organism. go.json adult locomotory behaviour http://purl.obolibrary.org/obo/GO_0008344 GO:0008343 biolink:BiologicalProcess adult feeding behavior Feeding behavior in a fully developed and mature organism. go.json adult feeding behaviour http://purl.obolibrary.org/obo/GO_0008343 GO:0008342 biolink:BiologicalProcess obsolete larval feeding behavior (sensu Insecta) OBSOLETE. Feeding behavior in an insect larva. go.json larval feeding behavior (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0008342 GO:0008341 biolink:BiologicalProcess obsolete response to cocaine (sensu Insecta) OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). go.json response to cocaine (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0008341 GO:0008340 biolink:BiologicalProcess determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal. go.json http://purl.obolibrary.org/obo/GO_0008340 GO:0008350 biolink:MolecularActivity obsolete kinetochore motor activity OBSOLETE. (Was not defined before being made obsolete). go.json kinetochore motor activity True http://purl.obolibrary.org/obo/GO_0008350 GO:0047919 biolink:MolecularActivity GDP-mannose 6-dehydrogenase activity Catalysis of the reaction: GDP-alpha-D-mannose + H2O + 2 NAD+ = GDP-D-mannuronate + 3 H+ + 2 NADH. EC:1.1.1.132|KEGG_REACTION:R00880|MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN|RHEA:21728 go.json GDP mannose dehydrogenase activity|GDP-D-mannose:NAD+ 6-oxidoreductase activity|GDPmannose 6-dehydrogenase activity|guanosine diphospho-D-mannose dehydrogenase activity|guanosine diphosphomannose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047919 GO:0047918 biolink:MolecularActivity GDP-mannose 3,5-epimerase activity Catalysis of the reaction: GDP-mannose = GDP-L-galactose. EC:5.1.3.18|MetaCyc:RXN-7772 go.json GDP-D-mannose:GDP-L-galactose epimerase activity|GDPmannose 3,5-epimerase activity|guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity http://purl.obolibrary.org/obo/GO_0047918 GO:0047917 biolink:MolecularActivity GDP-glucosidase activity Catalysis of the reaction: GDP-D-glucose + H2O = D-glucose + GDP + H+. EC:3.2.1.42|KEGG_REACTION:R00337|MetaCyc:GDP-GLUCOSIDASE-RXN|RHEA:15049 go.json GDP-glucose glucohydrolase activity|GDPglucose glucohydrolase activity|GDPglucosidase activity|guanosine diphosphate D-glucose glucohydrolase activity|guanosine diphosphoglucosidase activity http://purl.obolibrary.org/obo/GO_0047917 GO:0047916 biolink:MolecularActivity GDP-6-deoxy-D-talose 4-dehydrogenase activity Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+. EC:1.1.1.135|MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN go.json GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity|guanosine diphospho-6-deoxy-D-talose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047916 GO:0047915 biolink:MolecularActivity ganglioside galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine. EC:2.4.1.62|MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN|RHEA:16773 go.json GM1-synthase activity|UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity|UDP-galactose-GM2 galactosyltransferase activity|UDP-galactose-GM2 ganglioside galactosyltransferase activity|UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity|UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity|UDPgalactose-ceramide galactosyltransferase activity|UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity|uridine diphosphate D-galactose:glycolipid galactosyltransferase activity|uridine diphosphogalactose-GM2 galactosyltransferase activity|uridine diphosphogalactose-ceramide galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047915 GO:0047914 biolink:MolecularActivity gamma-glutamylhistamine synthase activity Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown. EC:6.3.2.18|MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN|RHEA:18881 go.json L-glutamate:histamine ligase activity|g-glutamylhistamine synthase activity|gamma-GHA synthetase activity|gamma-glutaminylhistamine synthetase activity http://purl.obolibrary.org/obo/GO_0047914 GO:0047913 biolink:MolecularActivity gallate 1-beta-glucosyltransferase activity Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP. EC:2.4.1.136|KEGG_REACTION:R03297|MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:15249 go.json UDP-glucose-vanillate 1-glucosyltransferase activity|UDP-glucose:gallate beta-D-glucosyltransferase activity|UDPglucose-vanillate 1-glucosyltransferase activity|UDPglucose:gallate beta-D-glucosyltransferase activity|UDPglucose:gallate glucosyltransferase activity|UDPglucose:vanillate 1-O-glucosyltransferase activity|gallate 1-b-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047913 GO:0047912 biolink:MolecularActivity galacturonokinase activity Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H+. EC:2.7.1.44|KEGG_REACTION:R01980|MetaCyc:GALACTURONOKINASE-RXN|RHEA:12965 go.json ATP:D-galacturonate 1-phosphotransferase activity|galacturonokinase (phosphorylating) D-galacturonic acid kinase activity http://purl.obolibrary.org/obo/GO_0047912 GO:0033303 biolink:BiologicalProcess quercetin O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin. MetaCyc:PWY-5321 go.json quercetin O-glucoside anabolism|quercetin O-glucoside biosynthesis|quercetin O-glucoside formation|quercetin O-glucoside synthesit http://purl.obolibrary.org/obo/GO_0033303 GO:0033302 biolink:BiologicalProcess quercetin O-glucoside metabolic process The chemical reactions and pathways involving O-glucosylated derivatives of quercetin. go.json quercetin O-glucoside metabolism http://purl.obolibrary.org/obo/GO_0033302 GO:0033301 biolink:BiologicalProcess cell cycle comprising mitosis without cytokinesis A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N). go.json http://purl.obolibrary.org/obo/GO_0033301 GO:0033300 biolink:MolecularActivity dehydroascorbic acid transmembrane transporter activity Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other. RHEA:60380|Reactome:R-HSA-198818 go.json dehydroascorbate transporter activity|dehydroascorbic acid transporter activity http://purl.obolibrary.org/obo/GO_0033300 GO:0008359 biolink:BiologicalProcess regulation of bicoid mRNA localization Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. go.json regulation of bicoid mRNA localisation http://purl.obolibrary.org/obo/GO_0008359 GO:0008358 biolink:BiologicalProcess maternal determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos. go.json http://purl.obolibrary.org/obo/GO_0008358 GO:0047922 biolink:MolecularActivity gentisate 1,2-dioxygenase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+. EC:1.13.11.4|KEGG_REACTION:R02656|MetaCyc:GENTISATE-12-DIOXYGENASE-RXN|RHEA:18237 go.json 2,5-dihydroxybenzoate dioxygenase activity|gentisate dioxygenase activity|gentisate oxygenase activity|gentisate:oxygen 1,2-oxidoreductase (decyclizing)|gentisic acid oxidase activity http://purl.obolibrary.org/obo/GO_0047922 GO:0047921 biolink:MolecularActivity aminoglycoside 2'-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H+. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring. EC:2.3.1.59|KEGG_REACTION:R03056|MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN|RHEA:24516 go.json acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity|acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity|gentamicin 2'-N-acetyltransferase activity|gentamicin acetyltransferase II activity|gentamycin 2'-N-acetyltransferase activity|gentamycin acetyltransferase II http://purl.obolibrary.org/obo/GO_0047921 GO:0008357 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008357 GO:0008356 biolink:BiologicalProcess asymmetric cell division The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. Wikipedia:Asymmetric_cell_division go.json asymmetric cytokinesis|asymmetrical cell division|asymmetrical cytokinesis http://purl.obolibrary.org/obo/GO_0008356 GO:0047920 biolink:MolecularActivity geissoschizine dehydrogenase activity Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH. EC:1.3.1.36|KEGG_REACTION:R03860|MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN|RHEA:11376 go.json geissoschizine:NADP+ 4,21-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047920 GO:0008355 biolink:BiologicalProcess olfactory learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. go.json http://purl.obolibrary.org/obo/GO_0008355 GO:0008354 biolink:BiologicalProcess germ cell migration The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. go.json germ-cell migration|primordial germ cell migration http://purl.obolibrary.org/obo/GO_0008354 GO:0008353 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. EC:2.7.11.23|MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN|RHEA:10216|Reactome:R-HSA-167191|Reactome:R-HSA-170704|Reactome:R-HSA-170706 go.json CTD kinase activity|RNA polymerase II carboxy-terminal domain kinase activity|RNA polymerase subunit kinase activity|RNA-polymerase-subunit kinase activity|[RNA-polymerase]-subunit kinase activity http://purl.obolibrary.org/obo/GO_0008353 GO:0008352 biolink:CellularComponent katanin complex A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). go.json http://purl.obolibrary.org/obo/GO_0008352 GO:0008351 biolink:MolecularActivity obsolete microtubule severing activity OBSOLETE. (Was not defined before being made obsolete). go.json microtubule severing activity True http://purl.obolibrary.org/obo/GO_0008351 GO:0008361 biolink:BiologicalProcess regulation of cell size Any process that modulates the size of a cell. go.json cell size control http://purl.obolibrary.org/obo/GO_0008361 GO:0047929 biolink:MolecularActivity gluconate dehydratase activity Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O. EC:4.2.1.39|KEGG_REACTION:R01538|MetaCyc:GLUCONATE-DEHYDRATASE-RXN|RHEA:21612 go.json D-gluconate dehydratase activity|D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)|D-gluconate hydro-lyase activity http://purl.obolibrary.org/obo/GO_0047929 GO:0008360 biolink:BiologicalProcess regulation of cell shape Any process that modulates the surface configuration of a cell. go.json http://purl.obolibrary.org/obo/GO_0008360 GO:0047928 biolink:MolecularActivity gibberellin beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside. EC:2.4.1.176|MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:20025 go.json UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity|UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity|gibberellin b-glucosyltransferase activity|uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity|uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047928 GO:0047927 biolink:MolecularActivity gibberellin-44 dioxygenase activity Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2. EC:1.14.11.12|MetaCyc:RXN1F-168|RHEA:16033 go.json (gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity|(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity|gibberellin A44 oxidase activity|oxygenase, gibberellin A44 oxidase activity http://purl.obolibrary.org/obo/GO_0047927 GO:0047926 biolink:MolecularActivity geranyl-diphosphate cyclase activity Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate. EC:5.5.1.8|KEGG_REACTION:R02007|MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN|RHEA:18209 go.json (+)-bornyl-diphosphate lyase (decyclizing)|(+)-bornylpyrophosphate cyclase activity|bornyl diphosphate synthase activity|bornyl pyrophosphate synthase activity|bornyl pyrophosphate synthetase activity http://purl.obolibrary.org/obo/GO_0047926 GO:0047925 biolink:MolecularActivity geranoyl-CoA carboxylase activity Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate. EC:6.4.1.5|KEGG_REACTION:R03494|MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN|RHEA:17701|UM-BBD_reactionID:r1166 go.json geranoyl coenzyme A carboxylase activity|geranoyl-CoA:carbon-dioxide ligase (ADP-forming)|geranyl-CoA carboxylase activity http://purl.obolibrary.org/obo/GO_0047925 GO:0047924 biolink:MolecularActivity geraniol dehydrogenase activity Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH. EC:1.1.1.183|MetaCyc:GERANIOL-DEHYDROGENASE-RXN|RHEA:14521|UM-BBD_reactionID:r1163 go.json geraniol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047924 GO:0047923 biolink:MolecularActivity gentisate decarboxylase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + H+ = CO2 + hydroquinone. EC:4.1.1.62|KEGG_REACTION:R02489|MetaCyc:GENTISATE-DECARBOXYLASE-RXN|RHEA:21312 go.json 2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)|2,5-dihydroxybenzoate decarboxylase activity|gentisate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0047923 GO:0033295 biolink:MolecularActivity hydroxyectoine binding Binding to hydroxyectoine. go.json http://purl.obolibrary.org/obo/GO_0033295 GO:0033294 biolink:MolecularActivity ectoine binding Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. go.json http://purl.obolibrary.org/obo/GO_0033294 GO:0033293 biolink:MolecularActivity monocarboxylic acid binding Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). go.json http://purl.obolibrary.org/obo/GO_0033293 GO:0033292 biolink:BiologicalProcess T-tubule organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. go.json T-tubule organisation|T-tubule organization and biogenesis|transverse tubule organization http://purl.obolibrary.org/obo/GO_0033292 GO:0033291 biolink:CellularComponent eukaryotic 80S initiation complex A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region. go.json http://purl.obolibrary.org/obo/GO_0033291 GO:0033290 biolink:CellularComponent eukaryotic 48S preinitiation complex The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC. go.json eukaryotic 48S initiation complex|eukaryotic 48S pre-initiation complex http://purl.obolibrary.org/obo/GO_0033290 GO:0033299 biolink:BiologicalProcess secretion of lysosomal enzymes The controlled release of lysosomal enzymes by a cell. go.json http://purl.obolibrary.org/obo/GO_0033299 GO:0033298 biolink:BiologicalProcess contractile vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. go.json contractile vacuole organisation|contractile vacuole organization and biogenesis http://purl.obolibrary.org/obo/GO_0033298 GO:0033297 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033297 GO:0033296 biolink:MolecularActivity rhamnose binding Binding to the D- or L-enantiomer of rhamnose. go.json http://purl.obolibrary.org/obo/GO_0033296 GO:0033284 biolink:MolecularActivity ATPase-coupled carboxylic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out). go.json ATP-dependent carboxylic acid transporter activity|carboxylic acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033284 GO:0033283 biolink:MolecularActivity ATPase-coupled organic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out). go.json ATP-dependent organic acid transmembrane transporter activity|organic acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033283 GO:0033282 biolink:CellularComponent protein C inhibitor-acrosin complex A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin. go.json PCI-ACR complex|PCI-acrosin complex|SERPINA5-acrosin complex|plasma serine protease inhibitor-acrosin complex|serpin A5-acrosin complex http://purl.obolibrary.org/obo/GO_0033282 GO:0033281 biolink:CellularComponent TAT protein transport complex A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. go.json TAT protein secretion complex|TAT protein translocation system complex|Twin-arginine translocation complex http://purl.obolibrary.org/obo/GO_0033281 GO:0033280 biolink:BiologicalProcess response to vitamin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. go.json response to calciferol|response to cholecalciferol|response to ergocalciferol http://purl.obolibrary.org/obo/GO_0033280 GO:0033289 biolink:CellularComponent intraconoid microtubule A microtubule located such that it threads through the conoid and projects through the polar ring. go.json http://purl.obolibrary.org/obo/GO_0033289 GO:0033288 biolink:MolecularActivity ATPase-coupled hydroxyectoine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out). go.json ATP-dependent hydroxyectoine transmembrane transporter activity|hydroxyectoine transmembrane transporter activity|hydroxyectoine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033288 GO:0033287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033287 GO:0033286 biolink:MolecularActivity ATPase-coupled ectoine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out). RHEA:32787 go.json ATP-dependent ectoine transmembrane transporter activity|ectoine transmembrane transporter activity|ectoine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033286 GO:0033285 biolink:MolecularActivity ATPase-coupled monocarboxylic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out). go.json ATP-dependent monocarboxylic acid transmembrane transporter activity|monocarboxylic acid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033285 GO:0033273 biolink:BiologicalProcess response to vitamin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. go.json http://purl.obolibrary.org/obo/GO_0033273 GO:0033272 biolink:BiologicalProcess myo-inositol hexakisphosphate transport The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json phytate transport http://purl.obolibrary.org/obo/GO_0033272 GO:0033271 biolink:BiologicalProcess myo-inositol phosphate transport The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0033271 GO:0033270 biolink:CellularComponent paranode region of axon An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. NIF_Subcellular:sao234066064|NIF_Subcellular:sao936144858 go.json paranode http://purl.obolibrary.org/obo/GO_0033270 GO:0033279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033279 GO:0033278 biolink:BiologicalProcess cell proliferation in midbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. go.json cell proliferation in mesencephalon|mesencepahalic cell proliferation http://purl.obolibrary.org/obo/GO_0033278 GO:0033277 biolink:BiologicalProcess obsolete abortive mitotic cell cycle OBSOLETE. A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy. go.json abortive mitosis True http://purl.obolibrary.org/obo/GO_0033277 GO:0033276 biolink:CellularComponent transcription factor TFTC complex A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0033276 GO:0033275 biolink:BiologicalProcess actin-myosin filament sliding The sliding movement of actin thin filaments and myosin thick filaments past each other. go.json actin filament sliding http://purl.obolibrary.org/obo/GO_0033275 GO:0033274 biolink:BiologicalProcess response to vitamin B2 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus. go.json response to riboflavin http://purl.obolibrary.org/obo/GO_0033274 GO:0033262 biolink:BiologicalProcess regulation of nuclear cell cycle DNA replication Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. go.json regulation of DNA replication during S phase|regulation of DNA replication involved in S phase|regulation of DNA replication involved in S-phase http://purl.obolibrary.org/obo/GO_0033262 GO:0033261 biolink:BiologicalProcess obsolete regulation of S phase OBSOLETE. A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle. MetaCyc:PWY-5043|MetaCyc:SALVADEHYPOX-PWY|MetaCyc:SALVPURINE2-PWY go.json regulation of S phase|regulation of S-phase|regulation of progression through S phase True http://purl.obolibrary.org/obo/GO_0033261 GO:0033260 biolink:BiologicalProcess nuclear DNA replication The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. go.json DNA replication during S phase|DNA replication involved in S phase|DNA replication involved in S-phase|nuclear cell cycle DNA replication http://purl.obolibrary.org/obo/GO_0033260 GO:0033269 biolink:CellularComponent internode region of axon An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath. NIF_Subcellular:sao206157942 go.json internode http://purl.obolibrary.org/obo/GO_0033269 GO:0033268 biolink:CellularComponent node of Ranvier An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. NIF_Subcellular:birnlex_1152_2|Wikipedia:Nodes_of_Ranvier go.json node of Ranvier axon http://purl.obolibrary.org/obo/GO_0033268 GO:0033267 biolink:CellularComponent obsolete axon part OBSOLETE. A part of an axon, a cell projection of a neuron. go.json True http://purl.obolibrary.org/obo/GO_0033267 GO:0033266 biolink:MolecularActivity ABC-type choline transporter activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane. go.json ABC-type choline transmembrane transporter activity|ATP-dependent choline transmembrane transporter activity|ATPase-coupled choline transmembrane transporter activity|choline-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0033266 GO:0033265 biolink:MolecularActivity choline binding Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium. go.json http://purl.obolibrary.org/obo/GO_0033265 GO:0033264 biolink:MolecularActivity obsolete bontoxilysin activity OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates. go.json BoNT|bontoxilysin activity|botulinum neurotoxin activity True http://purl.obolibrary.org/obo/GO_0033264 GO:0033263 biolink:CellularComponent CORVET complex A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. go.json http://purl.obolibrary.org/obo/GO_0033263 GO:0033251 biolink:MolecularActivity cephalosporinase activity Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin. MetaCyc:BETA-LACTAMASE-RXN go.json http://purl.obolibrary.org/obo/GO_0033251 GO:0033250 biolink:MolecularActivity penicillinase activity Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin. MetaCyc:BETA-LACTAMASE-RXN go.json http://purl.obolibrary.org/obo/GO_0033250 GO:0033259 biolink:BiologicalProcess plastid DNA replication The process in which new strands of DNA are synthesized in a plastid. go.json plastid DNA synthesis|replication of plastid DNA http://purl.obolibrary.org/obo/GO_0033259 GO:0033258 biolink:BiologicalProcess plastid DNA metabolic process The chemical reactions and pathways involving plastid DNA. go.json plastid DNA metabolism http://purl.obolibrary.org/obo/GO_0033258 GO:0033257 biolink:CellularComponent Bcl3/NF-kappaB2 complex A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription. go.json Bcl3-NFKB2 complex|Bcl3-p52 complex http://purl.obolibrary.org/obo/GO_0033257 GO:0033256 biolink:CellularComponent I-kappaB/NF-kappaB complex A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0033256 goslim_pir GO:0033255 biolink:CellularComponent SAS acetyltransferase complex A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p. go.json SAS-I complex http://purl.obolibrary.org/obo/GO_0033255 GO:0033254 biolink:CellularComponent vacuolar transporter chaperone complex A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p. go.json VTC complex http://purl.obolibrary.org/obo/GO_0033254 GO:0033253 biolink:BiologicalProcess regulation of penicillinase activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative. go.json http://purl.obolibrary.org/obo/GO_0033253 gocheck_do_not_annotate GO:0033252 biolink:BiologicalProcess regulation of beta-lactamase activity Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid. go.json http://purl.obolibrary.org/obo/GO_0033252 gocheck_do_not_annotate GO:0047892 biolink:MolecularActivity flavone apiosyltransferase activity Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone. EC:2.4.2.25|MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN|RHEA:19153 go.json UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity|UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity|uridine diphosphoapiose-flavone apiosyltransferase activity http://purl.obolibrary.org/obo/GO_0047892 GO:0047891 biolink:MolecularActivity flavone 7-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone. EC:2.4.1.81|MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:19577 go.json UDP-glucose-apigenin beta-glucosyltransferase activity|UDP-glucose-luteolin beta-D-glucosyltransferase activity|UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity|UDPglucose-apigenin beta-glucosyltransferase activity|UDPglucose-luteolin beta-D-glucosyltransferase activity|UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity|flavone 7-O-b-glucosyltransferase activity|uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity|uridine diphosphoglucose-luteolin glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047891 GO:0047890 biolink:MolecularActivity flavanone 4-reductase activity Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH. EC:1.1.1.234|MetaCyc:FLAVANONE-4-REDUCTASE-RXN|RHEA:11228 go.json (2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity|flavonone 4-reductase activity http://purl.obolibrary.org/obo/GO_0047890 GO:0047899 biolink:MolecularActivity formate dehydrogenase (NADP+) activity Catalysis of the reaction: formate + NADP+ = CO2 + NADPH. EC:1.17.1.10|KEGG_REACTION:R00134|MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN|RHEA:12000 go.json NADP-dependent formate dehydrogenase activity|formate:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047899 GO:0047898 biolink:MolecularActivity formate dehydrogenase (cytochrome) activity Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1. EC:1.2.2.1|MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:21520 go.json formate:cytochrome b1 oxidoreductase activity|formate:ferricytochrome-b1 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047898 GO:0047897 biolink:MolecularActivity formate-dihydrofolate ligase activity Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H+ + phosphate. EC:6.3.4.17|KEGG_REACTION:R02238|MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN|RHEA:24328 go.json dihydrofolate formyltransferase activity|formate:dihydrofolate ligase (ADP-forming)|formyl dihydrofolate synthase activity http://purl.obolibrary.org/obo/GO_0047897 GO:0047896 biolink:MolecularActivity formaldehyde transketolase activity Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone. EC:2.2.1.3|MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN|RHEA:24264 go.json D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity|DHAS activity|dihydroxyacetone synthase activity|glycerone synthase activity http://purl.obolibrary.org/obo/GO_0047896 GO:0047895 biolink:MolecularActivity formaldehyde dismutase activity Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate. EC:1.2.98.1|MetaCyc:RXN-11453|RHEA:19221 go.json aldehyde dismutase activity|cannizzanase activity|formaldehyde:formaldehyde oxidoreductase activity|nicotinoprotein aldehyde dismutase http://purl.obolibrary.org/obo/GO_0047895 GO:0047894 biolink:MolecularActivity flavonol 3-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate. EC:2.8.2.25|KEGG_REACTION:R02159|MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN|RHEA:13453 go.json 3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity|flavonol 3-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047894 goslim_chembl GO:0047893 biolink:MolecularActivity flavonol 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside. EC:2.4.1.91|MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN|RHEA:22300 go.json GTI|UDP-glucose flavonol 3-O-glucosyltransferase activity|UDP-glucose:flavonol 3-O-D-glucosyltransferase activity|UDP-glucose:flavonol 3-O-glucosyltransferase activity|UDPG:flavonoid-3-O-glucosyltransferase activity|UDPglucose:flavonol 3-O-D-glucosyltransferase activity|uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047893 GO:0033409 biolink:MolecularActivity UAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAU codon. go.json TAT codon-amino acid adaptor activity|tyrosine tRNA http://purl.obolibrary.org/obo/GO_0033409 GO:0033408 biolink:MolecularActivity UCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCG codon. go.json TCG codon-amino acid adaptor activity|serine tRNA http://purl.obolibrary.org/obo/GO_0033408 GO:0033407 biolink:MolecularActivity UCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCA codon. go.json TCA codon-amino acid adaptor activity|serine tRNA http://purl.obolibrary.org/obo/GO_0033407 GO:0033406 biolink:MolecularActivity UCC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCC codon. go.json TCC codon-amino acid adaptor activity|serine tRNA http://purl.obolibrary.org/obo/GO_0033406 GO:0008449 biolink:MolecularActivity N-acetylglucosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. EC:3.1.6.14|MetaCyc:3.1.6.14-RXN|Reactome:R-HSA-1638032|Reactome:R-HSA-2263495 go.json 2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity|N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity|N-acetylglucosamine 6-sulfate sulfatase activity|N-acetylglucosamine-6-sulphatase activity|O,N-disulfate O-sulfohydrolase activity|acetylglucosamine 6-sulfatase activity|chondroitinsulfatase|glucosamine-6-sulfatase activity http://purl.obolibrary.org/obo/GO_0008449 GO:0033405 biolink:MolecularActivity UCU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCU codon. go.json TCT codon-amino acid adaptor activity|serine tRNA http://purl.obolibrary.org/obo/GO_0033405 GO:0008448 biolink:MolecularActivity N-acetylglucosamine-6-phosphate deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. EC:3.5.1.25|MetaCyc:NAG6PDEACET-RXN|RHEA:22936|Reactome:R-HSA-6803789 go.json 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity|N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity|acetylaminodeoxyglucosephosphate acetylhydrolase activity|acetylglucosamine phosphate deacetylase activity http://purl.obolibrary.org/obo/GO_0008448 GO:0033404 biolink:MolecularActivity UUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUG codon. go.json TTG codon-amino acid adaptor activity|leucine tRNA http://purl.obolibrary.org/obo/GO_0033404 GO:0008447 biolink:MolecularActivity L-ascorbate oxidase activity Catalysis of the reaction: 4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O. EC:1.10.3.3|MetaCyc:RXN-3541|RHEA:30243 go.json AA oxidase activity|AAO|L-ascorbate:O2 oxidoreductase activity|L-ascorbate:oxygen oxidoreductase activity|L-ascorbic acid oxidase activity|ascorbase activity|ascorbate dehydrogenase activity|ascorbate oxidase activity|ascorbic acid oxidase activity|ascorbic oxidase activity http://purl.obolibrary.org/obo/GO_0008447 GO:0033403 biolink:MolecularActivity UUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUA codon. go.json TTA codon-amino acid adaptor activity|leucine tRNA http://purl.obolibrary.org/obo/GO_0033403 GO:0008446 biolink:MolecularActivity GDP-mannose 4,6-dehydratase activity Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O. EC:4.2.1.47|KEGG_REACTION:R00888|MetaCyc:GDPMANDEHYDRA-RXN|RHEA:23820|Reactome:R-HSA-6787632 go.json GDP-D-mannose 4,6-dehydratase activity|GDP-D-mannose dehydratase activity|GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)|GDP-mannose 4,6-hydro-lyase activity|GDPmannose 4,6-dehydratase activity|Gmd|guanosine 5'-diphosphate-D-mannose oxidoreductase activity|guanosine diphosphomannose 4,6-dehydratase activity|guanosine diphosphomannose oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008446 GO:0008445 biolink:MolecularActivity D-aspartate oxidase activity Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide. EC:1.4.3.1|MetaCyc:D-ASPARTATE-OXIDASE-RXN|RHEA:12512|Reactome:R-HSA-6810076 go.json D-aspartate:oxygen oxidoreductase (deaminating)|D-aspartic oxidase activity|aspartic oxidase activity http://purl.obolibrary.org/obo/GO_0008445 GO:0008444 biolink:MolecularActivity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+. EC:2.7.8.5|KEGG_REACTION:R01801|MetaCyc:PHOSPHAGLYPSYN-RXN|RHEA:12593|Reactome:R-HSA-1482939 go.json 3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity|CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity|CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity|CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity|CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity|PGP synthase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity|glycerol 3-phosphate phosphatidyltransferase activity|glycerol phosphate phosphatidyltransferase activity|glycerophosphate phosphatidyltransferase activity|phosphatidylglycerol phosphate synthase activity|phosphatidylglycerol phosphate synthetase activity|phosphatidylglycerolphosphate synthase activity|phosphatidylglycerophosphate synthase activity|phosphatidylglycerophosphate synthetase activity|sn-glycerol-3-phosphate phosphatidyltransferase activity http://purl.obolibrary.org/obo/GO_0008444 GO:0008443 biolink:MolecularActivity phosphofructokinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. go.json http://purl.obolibrary.org/obo/GO_0008443 GO:0008442 biolink:MolecularActivity 3-hydroxyisobutyrate dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. EC:1.1.1.31|MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN|RHEA:17681|Reactome:R-HSA-508473|Reactome:R-HSA-70885 go.json http://purl.obolibrary.org/obo/GO_0008442 GO:0008441 biolink:MolecularActivity 3'(2'),5'-bisphosphate nucleotidase activity Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. EC:3.1.3.7|MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN|RHEA:10040|Reactome:R-HSA-176606|Reactome:R-HSA-8953499 go.json 3'(2'),5' bisphosphate nucleotidase activity|3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity|3'-phosphoadenylylsulfate 3'-phosphatase activity|DPNPase activity|adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity|phosphoadenylate 3'-nucleotidase activity http://purl.obolibrary.org/obo/GO_0008441 GO:0008440 biolink:MolecularActivity inositol-1,4,5-trisphosphate 3-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+. EC:2.7.1.127|KEGG_REACTION:R03433|MetaCyc:2.7.1.127-RXN|RHEA:11020|Reactome:R-HSA-1855153|Reactome:R-HSA-1855233 go.json 1D-myo-inositol-trisphosphate 3-kinase activity|ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity|IP3 3-kinase activity|IP3K activity|Ins(1,4,5)P3 3-kinase activity|inositol trisphosphate 3-kinase activity|inositol-trisphosphate 3-kinase activity|ins(1,4,5)P(3) 3-kinase activity http://purl.obolibrary.org/obo/GO_0008440 GO:0033402 biolink:MolecularActivity UUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUC codon. go.json TTC codon-amino acid adaptor activity|phenylalanine tRNA http://purl.obolibrary.org/obo/GO_0033402 GO:0033401 biolink:MolecularActivity UUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUU codon. go.json TTT codon-amino acid adaptor activity|phenylalanine tRNA http://purl.obolibrary.org/obo/GO_0033401 GO:0033400 biolink:BiologicalProcess trans-zeatin metabolic process The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. go.json trans-zeatin metabolism http://purl.obolibrary.org/obo/GO_0033400 GO:0008459 biolink:MolecularActivity chondroitin 6-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. EC:2.8.2.17|MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN|RHEA:11108|Reactome:R-HSA-2018682|Reactome:R-HSA-3595175 go.json 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity|3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity|chondroitin 6-O-sulfotransferase activity|chondroitin 6-sulphotransferase activity|terminal 6-sulfotransferase activity http://purl.obolibrary.org/obo/GO_0008459 GO:0008458 biolink:MolecularActivity carnitine O-octanoyltransferase activity Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. EC:2.3.1.137|KEGG_REACTION:R03779|MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN|RHEA:17177|Reactome:R-HSA-390281 go.json carnitine medium-chain acyltransferase activity|easily solubilized mitochondrial carnitine palmitoyltransferase|medium-chain/long-chain carnitine acyltransferase activity|octanoyl-CoA:L-carnitine O-octanoyltransferase activity|overt mitochondrial carnitine palmitoyltransferase http://purl.obolibrary.org/obo/GO_0008458 GO:0008457 biolink:MolecularActivity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. EC:2.4.1.149|MetaCyc:2.4.1.163-RXN|RHEA:23004 go.json UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity|poly-N-acetyllactosamine extension enzyme activity|uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase http://purl.obolibrary.org/obo/GO_0008457 GO:0008456 biolink:MolecularActivity alpha-N-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. EC:3.2.1.49|MetaCyc:3.2.1.49-RXN|RHEA:15085 go.json N-acetyl-alpha-D-galactosaminidase activity|N-acetyl-alpha-galactosaminidase activity|alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity|alpha-NAGA activity|alpha-acetylgalactosaminidase activity|alpha-galactosidase B activity http://purl.obolibrary.org/obo/GO_0008456 GO:0008455 biolink:MolecularActivity alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. EC:2.4.1.143|MetaCyc:2.4.1.143-RXN|RHEA:12941|Reactome:R-HSA-4793955|Reactome:R-HSA-9694656|Reactome:R-HSA-975829 go.json GnTII activity|N-acetylglucosaminyltransferase II activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity|UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity|UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity|acetylglucosaminyltransferase II activity|alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity|alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0008455 GO:0008454 biolink:MolecularActivity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. EC:2.4.1.145|MetaCyc:2.4.1.145-RXN|RHEA:16057|Reactome:R-HSA-9696980|Reactome:R-HSA-975903 go.json GnTIV activity|N-acetylglucosaminyltransferase IV activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity|UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity|beta-acetylglucosaminyltransferase IV activity|uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity|uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV http://purl.obolibrary.org/obo/GO_0008454 GO:0008453 biolink:MolecularActivity alanine-glyoxylate transaminase activity Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. EC:2.6.1.44|MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN|RHEA:24248|Reactome:R-HSA-389684|Reactome:R-HSA-904864 go.json AGT activity|L-alanine-glycine transaminase activity|L-alanine:glyoxylate aminotransferase activity|alanine--glyoxylate aminotransferase activity|alanine-glyoxylate aminotransferase activity|alanine-glyoxylic aminotransferase activity http://purl.obolibrary.org/obo/GO_0008453 GO:0008452 biolink:MolecularActivity RNA ligase activity Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another. go.json http://purl.obolibrary.org/obo/GO_0008452 GO:0008451 biolink:MolecularActivity obsolete X-Pro aminopeptidase activity OBSOLETE. Catalysis of the release of an N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide. go.json X-Pro aminopeptidase activity|Xaa-Pro aminopeptidase activity|aminoacylproline aminopeptidase activity|aminopeptidase P|proline aminopeptidase True http://purl.obolibrary.org/obo/GO_0008451 GO:0008450 biolink:MolecularActivity obsolete O-sialoglycoprotein endopeptidase activity OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. go.json O-sialoglycoprotein endopeptidase activity|glycophorin A proteinase activity|glycoprotease activity|glycoproteinase activity|sialoglycoprotease activity|sialoglycoproteinase activity True http://purl.obolibrary.org/obo/GO_0008450 GO:0008460 biolink:MolecularActivity dTDP-glucose 4,6-dehydratase activity Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O. EC:4.2.1.46|KEGG_REACTION:R06513|MetaCyc:DTDPGLUCDEHYDRAT-RXN|RHEA:17221 go.json TDP-glucose oxidoreductase activity|dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)|dTDP-glucose 4,6-hydro-lyase activity|dTDPglucose 4,6-dehydratase activity|dTDPglucose 4,6-hydro-lyase activity|thymidine diphosphoglucose oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008460 GO:0008429 biolink:MolecularActivity phosphatidylethanolamine binding Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. go.json http://purl.obolibrary.org/obo/GO_0008429 GO:0008428 biolink:MolecularActivity ribonuclease inhibitor activity Binds to and stops, prevents or reduces the activity of ribonuclease. go.json http://purl.obolibrary.org/obo/GO_0008428 GO:0008427 biolink:MolecularActivity calcium-dependent protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase. go.json http://purl.obolibrary.org/obo/GO_0008427 GO:0008426 biolink:MolecularActivity protein kinase C inhibitor activity Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. go.json PKC inhibitor activity|diacylglycerol-activated phospholipid-dependent PKC inhibitor activity|diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity http://purl.obolibrary.org/obo/GO_0008426 GO:0008425 biolink:MolecularActivity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. go.json 2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity|coenzyme Q biosynthesis methyltransferase activity|coenzyme Q biosynthetic process methyltransferase activity|ubiquinone biosynthesis methyltransferase activity|ubiquinone biosynthetic process methyltransferase activity http://purl.obolibrary.org/obo/GO_0008425 GO:0008424 biolink:MolecularActivity glycoprotein 6-alpha-L-fucosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+. EC:2.4.1.68|KEGG_REACTION:R05988|MetaCyc:2.4.1.68-RXN|RHEA:12985|Reactome:R-HSA-1028788|Reactome:R-HSA-9696980 go.json FucT|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity|GDP-L-fucose--glycoprotein fucosyltransferase activity|GDP-fucose--glycoprotein fucosyltransferase activity|GDPfucose-glycoprotein fucosyltransferase activity|glycoprotein fucosyltransferase activity|guanosine diphosphofucose--glycoprotein fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0008424 GO:0008423 biolink:MolecularActivity obsolete bleomycin hydrolase activity OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred. go.json aminopeptidase C (Lactococcus lactis)|bleomycin hydrolase activity True http://purl.obolibrary.org/obo/GO_0008423 GO:0008422 biolink:MolecularActivity beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. EC:3.2.1.21|MetaCyc:3.2.1.21-RXN go.json amygdalase activity|amygdalinase|arbutinase activity|aryl-beta-glucosidase activity|beta-1,6-glucosidase activity|beta-D-glucosidase activity|beta-D-glucoside glucohydrolase activity|beta-glucoside glucohydrolase activity|cellobiase activity|cytokine beta-glucosidase activity|elaterase activity|emulsin|gentiobiase activity|gentobiase activity|limarase activity|p-nitrophenyl beta-glucosidase activity|primeverosidase activity|quercetin 3'-O-beta-D-glucopyranoside hydrolase activity|quercetin 4'-O-beta-D-glucopyranoside hydrolase activity|salicilinase activity http://purl.obolibrary.org/obo/GO_0008422 GO:0008421 biolink:MolecularActivity long-chain fatty-acyl-glutamate deacylase activity Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate. EC:3.5.1.55|MetaCyc:3.5.1.55-RXN|RHEA:17517 go.json N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity|long-chain acylglutamate amidase activity|long-chain aminoacylase activity|long-chain fatty acyl-glutamate deacylase activity|long-chain-fatty-acyl-glutamate deacylase activity http://purl.obolibrary.org/obo/GO_0008421 GO:0008420 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat phosphatase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate. go.json CTD phosphatase activity|RNA polymerase II carboxy-terminal domain phosphatase activity http://purl.obolibrary.org/obo/GO_0008420 GO:0008439 biolink:MolecularActivity obsolete monophenol monooxygenase activator activity OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase. go.json monophenol monooxygenase activator activity|prophenol oxidase activator True http://purl.obolibrary.org/obo/GO_0008439 GO:0008438 biolink:MolecularActivity obsolete 1-phosphatidylinositol-5-phosphate kinase OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide. go.json 1-phosphatidylinositol-5-phosphate kinase True http://purl.obolibrary.org/obo/GO_0008438 GO:0008437 biolink:MolecularActivity thyrotropin-releasing hormone activity The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. go.json TRH activity|thyrotropin releasing hormone activity http://purl.obolibrary.org/obo/GO_0008437 GO:0008436 biolink:MolecularActivity obsolete heterogeneous nuclear ribonucleoprotein OBSOLETE. (Was not defined before being made obsolete). go.json heterogeneous nuclear ribonucleoprotein|hnRNP True http://purl.obolibrary.org/obo/GO_0008436 GO:0008435 biolink:MolecularActivity obsolete anticoagulant activity OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation. go.json anticoagulant activity True http://purl.obolibrary.org/obo/GO_0008435 GO:0008434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008434 GO:0008433 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008433 GO:0008432 biolink:MolecularActivity JUN kinase binding Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. go.json JNK binding http://purl.obolibrary.org/obo/GO_0008432 GO:0008431 biolink:MolecularActivity vitamin E binding Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. go.json alpha-tocopherol binding|tocopherol binding http://purl.obolibrary.org/obo/GO_0008431 GO:0008430 biolink:MolecularActivity selenium binding Binding to a selenium (Se) ion. go.json http://purl.obolibrary.org/obo/GO_0008430 GO:0008409 biolink:MolecularActivity 5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. Reactome:R-HSA-5358599|Reactome:R-HSA-5358619 go.json http://purl.obolibrary.org/obo/GO_0008409 GO:0008408 biolink:MolecularActivity 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. Reactome:R-HSA-3245943 go.json 3'-5'-exonuclease activity http://purl.obolibrary.org/obo/GO_0008408 GO:0008407 biolink:BiologicalProcess chaeta morphogenesis The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. go.json bristle morphogenesis http://purl.obolibrary.org/obo/GO_0008407 GO:0008406 biolink:BiologicalProcess gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. go.json gonadogenesis http://purl.obolibrary.org/obo/GO_0008406 GO:0008405 biolink:MolecularActivity arachidonic acid 11,12-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid. RHEA:51480 go.json cytochrome P450 CYP2C38 http://purl.obolibrary.org/obo/GO_0008405 GO:0008404 biolink:MolecularActivity arachidonic acid 14,15-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid. RHEA:51472 go.json cytochrome P450 CYP2C29|cytochrome P450 CYP2C39 http://purl.obolibrary.org/obo/GO_0008404 GO:0008403 biolink:MolecularActivity 25-hydroxycholecalciferol-24-hydroxylase activity Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. go.json 25-hydroxyvitamin D3 24-hydroxylase activity|cytochrome P450 CYP24 http://purl.obolibrary.org/obo/GO_0008403 GO:0008402 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008402 GO:0008401 biolink:MolecularActivity retinoic acid 4-hydroxylase activity Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. Reactome:R-HSA-211874|Reactome:R-HSA-211923|Reactome:R-HSA-212007|Reactome:R-HSA-5362525|Reactome:R-HSA-5602050|Reactome:R-HSA-5602063 go.json cytochrome P450 CYP261 http://purl.obolibrary.org/obo/GO_0008401 GO:0008400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008400 GO:0141075 biolink:BiologicalProcess symbiont-mediated suppression of host JAK-STAT cascade A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host JAK-STAT cascade|down-regulation of host JAK-STAT cascade|downregulation of host JAK-STAT cascade|inhibition of host JAK-STAT cascade|negative regulation of host JAK-STAT cascade|suppression of host JAK-STAT cascade http://purl.obolibrary.org/obo/GO_0141075 GO:0141074 biolink:BiologicalProcess symbiont-mediated suppression of host cGAS-STING signal transduction A process in which a virus interferes with, inhibits or disrupt a cGAS/STING signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host cGAS-STING signal transduction|disruption of host cGAS-STING signaling|suppression of host cGAS-STING http://purl.obolibrary.org/obo/GO_0141074 GO:0141077 biolink:BiologicalProcess suppression of host interferon-mediated signaling pathway Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism. go.json inhibition of host interferon signaling pathway|negative regulation of host interferon-mediated signaling pathway|suppression of host IFN-mediated signaling pathway|suppression of host interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0141077 GO:0141076 biolink:BiologicalProcess symbiont-mediated suppression of host TRAF-mediated signal transduction A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host TRAF-mediated signal transduction|inhibition of host TRAF-mediated signal transduction|inhibition of host TRAFs|negative regulation of host TRAF-mediated signal transduction|suppression of host TRAF activity|suppression of host TRAF-mediated signal transduction|suppression of host tumor necrosis factor receptor-associated factor signaling http://purl.obolibrary.org/obo/GO_0141076 GO:0141079 biolink:BiologicalProcess symbiont-mediated activation of host inflammasome-mediated signal transduction A process in which a symbiont subverts an inflammasome-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json perturbation of host inflammasome-mediated signal transduction http://purl.obolibrary.org/obo/GO_0141079 GO:0141078 biolink:BiologicalProcess symbiont-mediated suppression of host RIG-I signaling pathway A process in which a symbiont interferes with, inhibits or disrupts a RIG-I signaling pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host RIG-1 signaling pathway|disruption of host RIG-I signaling pathway http://purl.obolibrary.org/obo/GO_0141078 GO:0141071 biolink:BiologicalProcess symbiont-mediated activation of host MAPK signal transduction pathway A process in which a symbiont subverts a MAPK signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host MAPK signal transduction pathway|induction by symbiont of host MAP kinase signal transduction pathway|induction of host MAPK kinase signaling pathway|stimulation by symbiont of host MAPK signal transduction pathway http://purl.obolibrary.org/obo/GO_0141071 GO:0141070 biolink:BiologicalProcess symbiont-mediated suppression of host MAPK signal transduction pathway A process in which a symbiont interferes with, inhibits or disrupts a MAPK signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host MAP kinase signaling pathway|disruption of host MAPK signal transduction pathway|disruption of host MAPK signaling pathway http://purl.obolibrary.org/obo/GO_0141070 GO:0141073 biolink:BiologicalProcess disruption by symbiont of host opsonization Any process in which a symbiont interferes with, inhibits or stops opsonization by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141073 GO:0141072 biolink:BiologicalProcess symbiont-mediated suppression of host tumor necrosis factor-mediated signaling pathway A process in which a virus interferes with, inhibits or disrupts a tumor necrosis factor-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of host TNF-mediated signaling pathway|disruption of host TNFR-mediated signaling pathway|disruption of host tumor necrosis factor receptor-mediated signaling pathway|disruption of host tumor necrosis factor-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0141072 GO:0008419 biolink:MolecularActivity RNA lariat debranching enzyme activity Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. go.json http://purl.obolibrary.org/obo/GO_0008419 GO:0008418 biolink:MolecularActivity protein-N-terminal asparagine amidohydrolase activity Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein. EC:3.5.1.121|RHEA:50676 go.json http://purl.obolibrary.org/obo/GO_0008418 GO:0008417 biolink:MolecularActivity fucosyltransferase activity Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. Reactome:R-HSA-9033949 go.json http://purl.obolibrary.org/obo/GO_0008417 GO:0008416 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008416 GO:0008415 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008415 GO:0008414 biolink:MolecularActivity CDP-alcohol phosphotransferase activity Catalysis of the transfer of a CDP-alcohol group from one compound to another. go.json http://purl.obolibrary.org/obo/GO_0008414 GO:0008413 biolink:MolecularActivity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. EC:3.6.1.69|RHEA:60032 go.json 7,8-dihydro-8-oxoguanine-triphosphatase activity|8-oxo-7,8-dihydroguanine triphosphatase activity|8-oxo-7,8-dihydroguanosine triphosphatase activity|8-oxo-GTPase activity http://purl.obolibrary.org/obo/GO_0008413 GO:0008412 biolink:MolecularActivity 4-hydroxybenzoate octaprenyltransferase activity Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate. EC:2.5.1.39|MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN|RHEA:27782 go.json 4-HB polyprenyltransferase activity|PHB polyprenyl diphosphate transferase activity|para-hydroxybenzoate transferase activity|para-hydroxybenzoate-polyprenyl diphosphate transferase activity|para-hydroxybenzoate:polyprenyltransferase activity http://purl.obolibrary.org/obo/GO_0008412 GO:0008411 biolink:MolecularActivity 4-hydroxybutyrate CoA-transferase activity Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate. go.json http://purl.obolibrary.org/obo/GO_0008411 GO:0008410 biolink:MolecularActivity CoA-transferase activity Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). EC:2.8.3.-|Reactome:R-HSA-70713 go.json http://purl.obolibrary.org/obo/GO_0008410 GO:0141064 biolink:BiologicalProcess zygotic genome activation A process that contributes to the onset of de novo transcription from the zygotic genome as part of the maternal-to-zygote transition in gene expression. The zygote overcomes the silencing that has been established. The cause of this silencing could be due to several factors: chromatin modifications leading to repression, or lack of adequate transcription machinery. go.json ZGA http://purl.obolibrary.org/obo/GO_0141064 GO:0141063 biolink:BiologicalProcess epigenetic programming in the central cell The establishment of epigenetic modifications (imprints) in a plant central cell, leading to an asymmetry between the two maternal alleles and the paternal allele, and differential expression of the corresponding alleles in the developing endosperm. This can happen through heterochromatin formation or differential chromatin loop formation. go.json http://purl.obolibrary.org/obo/GO_0141063 GO:0141066 biolink:BiologicalProcess symbiont-mediated disruption of host extracellular matrix The process in which an organism effects a change that impairs the structure or function of the host extracellular matrix. go.json disruption of host extracellular matrix http://purl.obolibrary.org/obo/GO_0141066 GO:0141065 biolink:BiologicalProcess maternal mRNA clearance The chemical reactions and pathways resulting in the clearance of maternal mRNA transcripts from the zygote as part of the maternal-to-zygote transition in gene expression. go.json maternal mRNA degradation|maternal transcript clearance|maternal transcript degradation http://purl.obolibrary.org/obo/GO_0141065 GO:0141068 biolink:BiologicalProcess autosome genomic imprinting The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation. go.json autosomal genomic imprinting|genomic imprinting of autosomal genes http://purl.obolibrary.org/obo/GO_0141068 GO:0141067 biolink:BiologicalProcess intracellular nitrogen homeostasis A homeostatic process involved in the maintenance of a steady state level of nitrogen within a cell. go.json cellular nitrogen homeostasis|nitrogen homeostasis http://purl.obolibrary.org/obo/GO_0141067 GO:0141069 biolink:MolecularActivity receptor ligand inhibitor activity Binds to and decreases the activity of the ligand of a signaling receptor. go.json signaling receptor ligand inhibitor activity http://purl.obolibrary.org/obo/GO_0141069 GO:0141060 biolink:BiologicalProcess disruption of anatomical structure in another organism The disruption of an anatomical structure of another organism, leading to damage or temporary subversion of that structure. go.json http://purl.obolibrary.org/obo/GO_0141060 GO:0141062 biolink:BiologicalProcess disruption of tissue in another organism The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue. go.json http://purl.obolibrary.org/obo/GO_0141062 GO:0141061 biolink:BiologicalProcess disruption of cell in another organism The disruption of a cell of another organism, leading to damage or temporary subversion of that cell. go.json http://purl.obolibrary.org/obo/GO_0141061 GO:0141097 biolink:MolecularActivity ligand-activated transcription activator activity A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets. go.json http://purl.obolibrary.org/obo/GO_0141097 GO:0141096 biolink:MolecularActivity ligand-activated transcription repressor activity A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets. go.json http://purl.obolibrary.org/obo/GO_0141096 GO:0141098 biolink:MolecularActivity tRNA (cytidine(34)-2'-O)-methyltransferase activity Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine. EC:2.1.1.207|RHEA:43084 go.json tRNA (cytidine 34-2'-O)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0141098 GO:0141091 biolink:BiologicalProcess transforming growth factor beta receptor superfamily signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TGF-beta receptor superfamily signaling pathway|TGF-beta receptor superfamily signalling pathway|TGFbeta receptor superfamily signaling pathway|TGFbeta receptor superfamily signalling pathway|transforming growth factor beta receptor superfamily signalling pathway http://purl.obolibrary.org/obo/GO_0141091 GO:0141090 biolink:MolecularActivity protein serine pyrophosphorylase activity Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate. RHEA:64104 go.json protein serine pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0141090 GO:0141093 biolink:MolecularActivity 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine. EC:2.5.1.147|MetaCyc:RXN-19229|RHEA:55200 go.json http://purl.obolibrary.org/obo/GO_0141093 GO:0141092 biolink:BiologicalProcess positive regulation of nodal signaling pathway Any process that increases the rate, frequency or extent of nodal signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0141092 GO:0141095 biolink:BiologicalProcess retrotransposon silencing by DNA methylation-dependent heterochromatin formation A retrotransposon silencing mechanism in which a methylated cytosine residues in the genome promote heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. go.json http://purl.obolibrary.org/obo/GO_0141095 GO:0141094 biolink:MolecularActivity DNA loop anchor binding Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase. go.json http://purl.obolibrary.org/obo/GO_0141094 GO:0141086 biolink:BiologicalProcess negative regulation of inflammasome-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an inflammasome-mediated signaling pathway. go.json negative regulation of inflammasome-mediated signal transduction http://purl.obolibrary.org/obo/GO_0141086 GO:0141085 biolink:BiologicalProcess regulation of inflammasome-mediated signaling pathway Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway. go.json regulation of inflammasome-mediated signal transduction http://purl.obolibrary.org/obo/GO_0141085 GO:0141088 biolink:BiologicalProcess symbiont-mediated activation of host autophagy A process in which a symbiont initiates, promotes, or enhances the activation of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json induction of host autophagy|positive regulation by symbiont of host autophagy http://purl.obolibrary.org/obo/GO_0141088 GO:0141087 biolink:BiologicalProcess positive regulation of inflammasome-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of an inflammasome-mediated signaling pathway. go.json positive regulation of inflammasome-mediated signal transduction http://purl.obolibrary.org/obo/GO_0141087 GO:0141089 biolink:MolecularActivity glucose sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose. go.json glucose sensing activity http://purl.obolibrary.org/obo/GO_0141089 GO:0141080 biolink:BiologicalProcess symbiont-mediated activation of host interferon signaling pathway A process in which a symbiont subverts an interferon-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. go.json http://purl.obolibrary.org/obo/GO_0141080 GO:0141082 biolink:BiologicalProcess symbiont-mediated detoxification of host-generated reactive oxygen species A process in which a symbiont interferes with, inhibits or disrupts the host reactive oxygen species (ROS)-mediated innate immune response by directly degrading host ROS. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141082 GO:0141081 biolink:BiologicalProcess symbiont-mediated suppression of host inflammasome-mediated signal transduction A process in which a symbiont interferes with, inhibits or stops an inflammasome-mediated signal transduction pathway in the host organism by interfering with its normal execution. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json perturbation of host inflammasome-mediated signal transduction http://purl.obolibrary.org/obo/GO_0141081 GO:0141084 biolink:BiologicalProcess inflammasome-mediated signaling pathway An intracellular signal transduction pathway that starts with a ligand binding to a pattern recognition receptor (PRR), assembly of the inflammasome complex, leading to the activation of CASP1 and inducing an inflammatory response. In some cases, inflammasome-mediated signal transduction can lead to programmed cell death, such as pyroptosis. go.json inflammasome-mediated signal transduction http://purl.obolibrary.org/obo/GO_0141084 GO:0141083 biolink:BiologicalProcess symbiont-mediated suppression of host reactive oxygen species generation A process in which a symbiont interferes with, inhibits or disrupts the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json inhibition by organism of defense-related host active oxygen species production http://purl.obolibrary.org/obo/GO_0141083 GO:0033482 biolink:BiologicalProcess D-galacturonate biosynthetic process The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. go.json D-galacturonate anabolism|D-galacturonate biosynthesis|D-galacturonate formation|D-galacturonate synthesis http://purl.obolibrary.org/obo/GO_0033482 GO:0033481 biolink:BiologicalProcess galacturonate biosynthetic process The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid. go.json galacturonate anabolism|galacturonate biosynthesis|galacturonate formation|galacturonate synthesis http://purl.obolibrary.org/obo/GO_0033481 GO:0033480 biolink:BiologicalProcess UDP-D-galacturonate biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-4 go.json UDP-D-galacturonate anabolism|UDP-D-galacturonate biosynthesis|UDP-D-galacturonate formation|UDP-D-galacturonate synthesis http://purl.obolibrary.org/obo/GO_0033480 GO:0033489 biolink:BiologicalProcess cholesterol biosynthetic process via desmosterol The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol. MetaCyc:PWY66-4 go.json cholesterol anabolism via desmosterol|cholesterol biosynthesis via desmosterol|cholesterol formation via desmosterol|cholesterol synthesis via desmosterol http://purl.obolibrary.org/obo/GO_0033489 GO:0033488 biolink:BiologicalProcess cholesterol biosynthetic process via 24,25-dihydrolanosterol The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol. MetaCyc:PWY66-3 go.json cholesterol anabolism via 24,25-dihydrolanosterol|cholesterol biosynthesis via 24,25-dihydrolanosterol|cholesterol formation via 24,25-dihydrolanosterol|cholesterol synthesis via 24,25-dihydrolanosterol http://purl.obolibrary.org/obo/GO_0033488 GO:0033487 biolink:BiologicalProcess pelargonidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. MetaCyc:PWY-5125 go.json pelargonidin 3-O-glucoside anabolism|pelargonidin 3-O-glucoside biosynthesis|pelargonidin 3-O-glucoside formation|pelargonidin 3-O-glucoside synthesis http://purl.obolibrary.org/obo/GO_0033487 GO:0033486 biolink:BiologicalProcess delphinidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits. MetaCyc:PWY-5153 go.json delphinidin 3-O-glucoside anabolism|delphinidin 3-O-glucoside biosynthesis|delphinidin 3-O-glucoside formation|delphinidin 3-O-glucoside synthesis http://purl.obolibrary.org/obo/GO_0033486 GO:0033485 biolink:BiologicalProcess cyanidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. MetaCyc:PWY-5125 go.json cyanidin 3-O-glucoside anabolism|cyanidin 3-O-glucoside biosynthesis|cyanidin 3-O-glucoside formation|cyanidin 3-O-glucoside synthesis http://purl.obolibrary.org/obo/GO_0033485 GO:0033484 biolink:BiologicalProcess intracellular nitric oxide homeostasis A homeostatic process involved in the maintenance of a steady state level of nitric oxide within a cell. go.json NO homeostasis|cellular nitric oxide homeostasis|nitric oxide homeostasis http://purl.obolibrary.org/obo/GO_0033484 GO:0033483 biolink:BiologicalProcess obsolete gas homeostasis OBSOLETE. A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0033483 GO:0033471 biolink:BiologicalProcess GDP-L-galactose metabolic process The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate. go.json GDP-L-galactose metabolism http://purl.obolibrary.org/obo/GO_0033471 GO:0033470 biolink:BiologicalProcess gibberellin 12 biosynthetic process The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid. MetaCyc:PWY-5034 go.json GA12 biosynthetic process|gibberellin 12 anabolism|gibberellin 12 biosynthesis|gibberellin 12 formation|gibberellin 12 synthesis|gibberellin A12 biosynthetic process http://purl.obolibrary.org/obo/GO_0033470 GO:0033479 biolink:BiologicalProcess UDP-D-galacturonate metabolic process The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate. go.json UDP-D-galacturonate metabolism http://purl.obolibrary.org/obo/GO_0033479 GO:0033478 biolink:BiologicalProcess UDP-rhamnose metabolic process The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate. MetaCyc:PWY-3261 go.json UDP-rhamnose metabolism http://purl.obolibrary.org/obo/GO_0033478 GO:0033477 biolink:BiologicalProcess S-methylmethionine metabolic process The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle. go.json S-methylmethionine metabolism http://purl.obolibrary.org/obo/GO_0033477 GO:0033476 biolink:BiologicalProcess indoleacetic acid ester conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond. MetaCyc:PWY-1741 go.json IAA ester conjugate biosynthetic process|indole acetic acid ester conjugate biosynthesis|indole acetic acid ester conjugate biosynthetic process|indoleacetic acid ester conjugate anabolism|indoleacetic acid ester conjugate biosynthesis|indoleacetic acid ester conjugate formation|indoleacetic acid ester conjugate synthesis http://purl.obolibrary.org/obo/GO_0033476 GO:0033475 biolink:BiologicalProcess indoleacetic acid amide conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond. MetaCyc:PWY-1782 go.json IAA amide conjugate biosynthetic process|indole acetic acid amide conjugate biosynthesis|indole acetic acid amide conjugate biosynthetic process|indoleacetic acid amide conjugate anabolism|indoleacetic acid amide conjugate biosynthesis|indoleacetic acid amide conjugate formation|indoleacetic acid amide conjugate synthesis http://purl.obolibrary.org/obo/GO_0033475 GO:0033474 biolink:BiologicalProcess indoleacetic acid conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. go.json IAA conjugate biosynthetic process|indole acetic acid conjugate biosynthesis|indole acetic acid conjugate biosynthetic process|indoleacetic acid conjugate anabolism|indoleacetic acid conjugate biosynthesis|indoleacetic acid conjugate formation|indoleacetic acid conjugate synthesis http://purl.obolibrary.org/obo/GO_0033474 GO:0033473 biolink:BiologicalProcess indoleacetic acid conjugate metabolic process The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. go.json IAA conjugate metabolic process|indole acetic acid conjugate metabolic process|indole acetic acid conjugate metabolism|indoleacetic acid conjugate metabolism http://purl.obolibrary.org/obo/GO_0033473 GO:0033472 biolink:BiologicalProcess GDP-L-galactose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate. MetaCyc:PWY-5115 go.json GDP-L-galactose anabolism|GDP-L-galactose biosynthesis|GDP-L-galactose formation|GDP-L-galactose synthesis http://purl.obolibrary.org/obo/GO_0033472 GO:0033469 biolink:BiologicalProcess gibberellin 12 metabolic process The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid. go.json GA12 metabolic process|gibberellin 12 metabolism|gibberellin A12 metabolic process http://purl.obolibrary.org/obo/GO_0033469 GO:0033460 biolink:MolecularActivity GAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAG codon. go.json glutamic acid tRNA http://purl.obolibrary.org/obo/GO_0033460 GO:0033468 biolink:BiologicalProcess CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate. MetaCyc:KDOSYN-PWY|MetaCyc:PWY-1269 go.json CMP-KDO biosynthesis|CMP-KDO biosynthetic process|CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism|CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis|CMP-keto-3-deoxy-D-manno-octulosonic acid formation|CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis|CMP-ketodeoxyoctanoate biosynthetic process http://purl.obolibrary.org/obo/GO_0033468 GO:0033467 biolink:BiologicalProcess CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate. go.json CMP-KDO metabolic process|CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism|CMP-ketodeoxyoctanoate metabolic process http://purl.obolibrary.org/obo/GO_0033467 GO:0033466 biolink:BiologicalProcess trans-zeatin biosynthetic process The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. MetaCyc:PWY-2681 go.json trans-zeatin anabolism|trans-zeatin biosynthesis|trans-zeatin formation|trans-zeatin synthesis http://purl.obolibrary.org/obo/GO_0033466 GO:0033465 biolink:BiologicalProcess cis-zeatin biosynthetic process The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. MetaCyc:PWY-2781 go.json cis-zeatin anabolism|cis-zeatin biosynthesis|cis-zeatin formation|cis-zeatin synthesis http://purl.obolibrary.org/obo/GO_0033465 GO:0033464 biolink:MolecularActivity GGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGG codon. go.json glycine tRNA http://purl.obolibrary.org/obo/GO_0033464 GO:0033463 biolink:MolecularActivity GGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGA codon. go.json glycine tRNA http://purl.obolibrary.org/obo/GO_0033463 GO:0033462 biolink:MolecularActivity GGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGC codon. go.json glycine tRNA http://purl.obolibrary.org/obo/GO_0033462 GO:0033461 biolink:MolecularActivity GGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGU codon. go.json GGT codon-amino acid adaptor activity|glycine tRNA http://purl.obolibrary.org/obo/GO_0033461 GO:0033459 biolink:MolecularActivity GAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAA codon. go.json glutamic acid tRNA http://purl.obolibrary.org/obo/GO_0033459 GO:0033458 biolink:MolecularActivity GAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAC codon. go.json aspartic acid tRNA http://purl.obolibrary.org/obo/GO_0033458 GO:0033457 biolink:MolecularActivity GAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAU codon. go.json GAT codon-amino acid adaptor activity|aspartic acid tRNA http://purl.obolibrary.org/obo/GO_0033457 GO:0033456 biolink:MolecularActivity GCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCG codon. go.json alanine tRNA http://purl.obolibrary.org/obo/GO_0033456 GO:0033455 biolink:MolecularActivity GCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCA codon. go.json alanine tRNA http://purl.obolibrary.org/obo/GO_0033455 GO:0033454 biolink:MolecularActivity GCC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCC codon. go.json alanine tRNA http://purl.obolibrary.org/obo/GO_0033454 GO:0033453 biolink:MolecularActivity GCU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCU codon. go.json GCT codon-amino acid adaptor activity|alanine tRNA http://purl.obolibrary.org/obo/GO_0033453 GO:0033452 biolink:MolecularActivity GUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUG codon. go.json GTG codon-amino acid adaptor activity|valine tRNA http://purl.obolibrary.org/obo/GO_0033452 GO:0033451 biolink:MolecularActivity GUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUA codon. go.json GTA codon-amino acid adaptor activity|valine tRNA http://purl.obolibrary.org/obo/GO_0033451 GO:0033450 biolink:MolecularActivity GUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUC codon. go.json GTC codon-amino acid adaptor activity|valine tRNA http://purl.obolibrary.org/obo/GO_0033450 GO:0033449 biolink:MolecularActivity GUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUU codon. go.json GTT codon-amino acid adaptor activity|valine tRNA http://purl.obolibrary.org/obo/GO_0033449 GO:0033448 biolink:MolecularActivity AGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGG codon. go.json arginine tRNA http://purl.obolibrary.org/obo/GO_0033448 GO:0033447 biolink:MolecularActivity AGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGA codon. go.json arginine tRNA http://purl.obolibrary.org/obo/GO_0033447 GO:0008489 biolink:MolecularActivity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. go.json LacCer synthase activity|UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity|lactosylceramide synthase activity http://purl.obolibrary.org/obo/GO_0008489 GO:0008488 biolink:MolecularActivity gamma-glutamyl carboxylase activity Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. EC:4.1.1.90|RHEA:45140|Reactome:R-HSA-159752|Reactome:R-HSA-159761|Reactome:R-HSA-159795|Reactome:R-HSA-159803|Reactome:R-HSA-159819|Reactome:R-HSA-159826|Reactome:R-HSA-163810|Reactome:R-HSA-163820|Reactome:R-HSA-6807214|Reactome:R-HSA-9673231 go.json http://purl.obolibrary.org/obo/GO_0008488 GO:0008487 biolink:MolecularActivity obsolete prenyl-dependent CAAX protease activity OBSOLETE. (Was not defined before being made obsolete). go.json prenyl-dependent CAAX protease activity True http://purl.obolibrary.org/obo/GO_0008487 GO:0008486 biolink:MolecularActivity diphosphoinositol-polyphosphate diphosphatase activity Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate. EC:3.6.1.52|KEGG_REACTION:R05777|MetaCyc:3.6.1.52-RXN go.json DIPP activity|diphospho-myo-inositol-polyphosphate diphosphohydrolase activity|diphosphoinositol polyphosphate phosphohydrolase activity|diphosphoinositol-polyphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0008486 GO:0008485 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008485 GO:0008484 biolink:MolecularActivity sulfuric ester hydrolase activity Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. EC:3.1.6.- go.json sulfatase activity|sulphuric ester hydrolase activity http://purl.obolibrary.org/obo/GO_0008484 GO:0008483 biolink:MolecularActivity transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. EC:2.6.1.-|Reactome:R-HSA-1237102 go.json aminotransferase activity http://purl.obolibrary.org/obo/GO_0008483 GO:0008493 biolink:MolecularActivity tetracycline transmembrane transporter activity Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). go.json tetracyclin transporter activity|tetracycline transporter activity http://purl.obolibrary.org/obo/GO_0008493 GO:0008492 biolink:MolecularActivity obsolete cAMP generating peptide activity OBSOLETE. (Was not defined before being made obsolete). go.json cAMP generating peptide activity|cyclic AMP generating peptide activity True http://purl.obolibrary.org/obo/GO_0008492 GO:0008491 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008491 GO:0008490 biolink:MolecularActivity arsenite secondary active transmembrane transporter activity Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json arsenite porter activity http://purl.obolibrary.org/obo/GO_0008490 GO:0033446 biolink:MolecularActivity AGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGC codon. go.json serine tRNA http://purl.obolibrary.org/obo/GO_0033446 GO:0033445 biolink:MolecularActivity AGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGU codon. go.json AGT codon-amino acid adaptor activity|serine tRNA http://purl.obolibrary.org/obo/GO_0033445 GO:0033444 biolink:MolecularActivity AAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAG codon. go.json lysine tRNA http://purl.obolibrary.org/obo/GO_0033444 GO:0033443 biolink:MolecularActivity AAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAA codon. go.json lysine tRNA http://purl.obolibrary.org/obo/GO_0033443 GO:0033442 biolink:MolecularActivity AAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAC codon. go.json asparagine tRNA http://purl.obolibrary.org/obo/GO_0033442 GO:0033441 biolink:MolecularActivity AAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAU codon. go.json AAT codon-amino acid adaptor activity|asparagine tRNA http://purl.obolibrary.org/obo/GO_0033441 GO:0033440 biolink:MolecularActivity ACG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACG codon. go.json threonine tRNA http://purl.obolibrary.org/obo/GO_0033440 GO:0033439 biolink:MolecularActivity ACA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACA codon. go.json threonine tRNA http://purl.obolibrary.org/obo/GO_0033439 GO:0033438 biolink:MolecularActivity ACC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACC codon. go.json threonine tRNA http://purl.obolibrary.org/obo/GO_0033438 GO:0033437 biolink:MolecularActivity ACU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACU codon. go.json ACT codon-amino acid adaptor activity|threonine tRNA http://purl.obolibrary.org/obo/GO_0033437 GO:0033436 biolink:MolecularActivity AUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUG codon. go.json ATG codon-amino acid adaptor activity|initiator methionine tRNA|methionine tRNA http://purl.obolibrary.org/obo/GO_0033436 GO:0008499 biolink:MolecularActivity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. Reactome:R-HSA-914010|Reactome:R-HSA-9603989 go.json UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity|UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|beta-1,3-GalTase activity|beta3Gal-Ts activity http://purl.obolibrary.org/obo/GO_0008499 GO:0008498 biolink:MolecularActivity obsolete phospholipid scrambling OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions. go.json phospholipid scrambling True http://purl.obolibrary.org/obo/GO_0008498 GO:0008497 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008497 GO:0008496 biolink:MolecularActivity mannan endo-1,6-alpha-mannosidase activity Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. EC:3.2.1.101|MetaCyc:3.2.1.101-RXN|Reactome:R-HSA-6799581 go.json 1,6-alpha-D-mannan mannanohydrolase activity|1,6-beta-D-mannan mannanohydrolase activity|endo-1,6-beta-mannanase activity|endo-alpha-1->6-D-mannanase activity|endo-alpha-D-mannosidase activity|exo-1,6-beta-mannanase activity|mannan endo-1,6-beta-mannosidase activity http://purl.obolibrary.org/obo/GO_0008496 GO:0008495 biolink:MolecularActivity protoheme IX farnesyltransferase activity Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. EC:2.5.1.141|MetaCyc:HEMEOSYN-RXN|RHEA:28070|Reactome:R-HSA-2995330 go.json haem O synthase activity|heme A:farnesyltransferase activity|heme O synthase activity|protohaem IX farnesyltransferase activity http://purl.obolibrary.org/obo/GO_0008495 GO:0008494 biolink:MolecularActivity translation activator activity Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. go.json http://purl.obolibrary.org/obo/GO_0008494 GO:0033435 biolink:MolecularActivity AUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUA codon. go.json ATA codon-amino acid adaptor activity|isoleucine tRNA http://purl.obolibrary.org/obo/GO_0033435 GO:0033434 biolink:MolecularActivity AUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUC codon. go.json ATC codon-amino acid adaptor activity|isoleucine tRNA http://purl.obolibrary.org/obo/GO_0033434 GO:0033433 biolink:MolecularActivity AUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUU codon. go.json ATT codon-amino acid adaptor activity|isoleucine tRNA http://purl.obolibrary.org/obo/GO_0033433 GO:0033432 biolink:MolecularActivity CGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGG codon. go.json arginine tRNA http://purl.obolibrary.org/obo/GO_0033432 GO:0033431 biolink:MolecularActivity CGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGA codon. go.json arginine tRNA http://purl.obolibrary.org/obo/GO_0033431 GO:0033430 biolink:MolecularActivity CGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGC codon. go.json arginine tRNA http://purl.obolibrary.org/obo/GO_0033430 GO:0033429 biolink:MolecularActivity CGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGU codon. go.json CGT codon-amino acid adaptor activity|arginine tRNA http://purl.obolibrary.org/obo/GO_0033429 GO:0033428 biolink:MolecularActivity CAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAG codon. go.json glutamine tRNA http://purl.obolibrary.org/obo/GO_0033428 GO:0033427 biolink:MolecularActivity CAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAA codon. go.json glutamine tRNA http://purl.obolibrary.org/obo/GO_0033427 GO:0033426 biolink:MolecularActivity CAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAC codon. go.json histidine tRNA http://purl.obolibrary.org/obo/GO_0033426 GO:0008469 biolink:MolecularActivity histone arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. go.json S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity|S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity|histone-arginine N-methylase activity|histone-arginine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008469 GO:0033425 biolink:MolecularActivity CAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAU codon. go.json CAT codon-amino acid adaptor activity|histidine tRNA http://purl.obolibrary.org/obo/GO_0033425 GO:0008468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008468 GO:0008467 biolink:MolecularActivity [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. EC:2.8.2.23|MetaCyc:2.8.2.23-RXN|Reactome:R-HSA-2076383|Reactome:R-HSA-2076611 go.json 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase|3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity|3-OST-1 activity|glucosaminyl 3-O-sulfotransferase activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity|heparin-glucosamine 3-O-sulfotransferase activity|heparin-glucosamine 3-O-sulphotransferase activity|isoform/isozyme 1 (3-OST-1, HS3ST1) http://purl.obolibrary.org/obo/GO_0008467 GO:0008466 biolink:MolecularActivity glycogenin glucosyltransferase activity Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. EC:2.4.1.186|MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN|RHEA:23360|Reactome:R-HSA-3322003|Reactome:R-HSA-3322014|Reactome:R-HSA-3322019|Reactome:R-HSA-3322025|Reactome:R-HSA-3814838 go.json 1,4alpha-glucan-protein synthase (UDP-forming) activity|UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity|UDP-glucose:glycogenin glucosyltransferase activity|alpha-1,4-glucan-protein synthase (UDP-forming) activity|glycogenin activity|priming glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0008466 GO:0008465 biolink:MolecularActivity glycerate dehydrogenase activity Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. EC:1.1.1.29|MetaCyc:GLYCERATE-DEHYDROGENASE-RXN|RHEA:17905 go.json hydroxypyruvate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008465 GO:0008464 biolink:MolecularActivity obsolete gamma-glutamyl hydrolase activity OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid. go.json carboxypeptidase G activity|conjugase activity|folate conjugase activity|folic acid conjugase activity|gamma-Glu-X carboxypeptidase activity|gamma-glutamyl hydrolase activity|lysosomal gamma-glutamyl carboxypeptidase activity|poly(gamma-glutamic acid) endohydrolase activity|poly(glutamic acid) hydrolase II|polyglutamate hydrolase activity|pteroyl-poly-alpha-glutamate hydrolase activity|pteroyl-poly-gamma-glutamate hydrolase activity|pteroylpoly-gamma-glutamyl hydrolase activity True http://purl.obolibrary.org/obo/GO_0008464 GO:0008463 biolink:MolecularActivity formylmethionine deformylase activity Catalysis of the reaction: N-formyl-L-methionine + H2O = L-methionine + formate. EC:3.5.1.31|KEGG_REACTION:R00653|MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN|RHEA:17781 go.json N-formyl-L-methionine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0008463 GO:0008462 biolink:MolecularActivity obsolete endopeptidase Clp activity OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs). go.json ATP-dependent Clp protease|Clp protease|ClpP|caseinolytic protease activity|endopeptidase Clp activity|endopeptidase Ti activity|protease Ti activity True http://purl.obolibrary.org/obo/GO_0008462 GO:0008461 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008461 GO:0008471 biolink:MolecularActivity obsolete laccase activity OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. go.json benzenediol:oxygen oxidoreductase activity|laccase activity|p-diphenol oxidase activity|urishiol oxidase activity|urushiol oxidase activity True http://purl.obolibrary.org/obo/GO_0008471 GO:0008470 biolink:MolecularActivity isovaleryl-CoA dehydrogenase activity Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. EC:1.3.8.4|MetaCyc:RXN0-2301|RHEA:12276|Reactome:R-HSA-70745 go.json 3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity|3-methylbutanoyl-CoA:acceptor oxidoreductase activity|isovaleroyl-coenzyme A dehydrogenase activity|isovaleryl-coenzyme A dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008470 GO:0033424 biolink:MolecularActivity CCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCG codon. go.json proline tRNA http://purl.obolibrary.org/obo/GO_0033424 GO:0033423 biolink:MolecularActivity CCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCA codon. go.json proline tRNA http://purl.obolibrary.org/obo/GO_0033423 GO:0033422 biolink:MolecularActivity CCC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCC codon. go.json proline tRNA http://purl.obolibrary.org/obo/GO_0033422 GO:0033421 biolink:MolecularActivity CCU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCU codon. go.json CCT codon-amino acid adaptor activity|proline tRNA http://purl.obolibrary.org/obo/GO_0033421 GO:0033420 biolink:MolecularActivity CUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUG codon. go.json CTG codon-amino acid adaptor activity|leucine tRNA http://purl.obolibrary.org/obo/GO_0033420 GO:0033419 biolink:MolecularActivity CUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUA codon. go.json CTA codon-amino acid adaptor activity|leucine tRNA http://purl.obolibrary.org/obo/GO_0033419 GO:0033418 biolink:MolecularActivity CUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUC codon. go.json CTC codon-amino acid adaptor activity|leucine tRNA http://purl.obolibrary.org/obo/GO_0033418 GO:0033417 biolink:MolecularActivity CUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUU codon. go.json CTT codon-amino acid adaptor activity|leucine tRNA http://purl.obolibrary.org/obo/GO_0033417 GO:0033416 biolink:MolecularActivity UGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGG codon. go.json TGG codon-amino acid adaptor activity|tryptophan tRNA http://purl.obolibrary.org/obo/GO_0033416 GO:0033415 biolink:MolecularActivity UGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGA codon. go.json TGA codon-amino acid adaptor activity http://purl.obolibrary.org/obo/GO_0033415 GO:0033414 biolink:MolecularActivity UGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGC codon. go.json TGC codon-amino acid adaptor activity|cysteine tRNA http://purl.obolibrary.org/obo/GO_0033414 GO:0008479 biolink:MolecularActivity tRNA-guanosine(34) queuine transglycosylase activity Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA. EC:2.4.2.64|MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN|RHEA:16633|Reactome:R-HSA-6782443 go.json Q-insertase|TGT|eTGT|guanine insertion enzyme|queuine tRNA-ribosyltransferase|queuine tRNA-ribosyltransferase activity|queuine(34) transfer ribonucleate ribosyltransferase|tRNA guanine transglycosylase|tRNA transglycosylase|tRNA-guanosine(34) queuine transglycosylase http://purl.obolibrary.org/obo/GO_0008479 GO:0008478 biolink:MolecularActivity pyridoxal kinase activity Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. EC:2.7.1.35|MetaCyc:PYRIDOXKIN-RXN|RHEA:10224|Reactome:R-HSA-964958|Reactome:R-HSA-964962|Reactome:R-HSA-964970 go.json ATP:pyridoxal 5'-phosphotransferase activity|pyridoxal 5-phosphate-kinase activity|pyridoxal kinase (phosphorylating)|pyridoxal phosphokinase activity|pyridoxamine kinase activity|pyridoxine kinase activity|vitamin B(6) kinase activity|vitamin B6 kinase activity http://purl.obolibrary.org/obo/GO_0008478 GO:0008477 biolink:MolecularActivity purine nucleosidase activity Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. EC:3.2.2.1|MetaCyc:PURINE-NUCLEOSIDASE-RXN|RHEA:23344 go.json IAG-NH activity|IAG-nucleoside hydrolase activity|N-D-ribosylpurine ribohydrolase activity|N-ribosyl purine ribohydrolase activity|inosine-adenosine-guanosine preferring nucleoside hydrolase activity|nucleosidase activity|nucleosidase g activity|nucleoside hydrolase activity|purine beta-ribosidase activity|purine nucleosidase reaction|purine nucleoside hydrolase activity|purine ribonucleosidase activity|purine-nucleoside ribohydrolase activity|purine-specific nucleoside N-ribohydrolase activity|ribonucleoside hydrolase activity http://purl.obolibrary.org/obo/GO_0008477 GO:0008476 biolink:MolecularActivity protein-tyrosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. EC:2.8.2.20|MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN|RHEA:16801|Reactome:R-HSA-8954262|Reactome:R-HSA-9668023|Reactome:R-HSA-9668148 go.json 3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity|protein-tyrosine sulphotransferase activity|tyrosylprotein sulfotransferase activity http://purl.obolibrary.org/obo/GO_0008476 goslim_chembl GO:0008475 biolink:MolecularActivity procollagen-lysine 5-dioxygenase activity Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. EC:1.14.11.4|MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN|RHEA:16569|Reactome:R-HSA-1981104 go.json collagen lysine hydroxylase activity|lysine hydroxylase activity|lysine,2-oxoglutarate 5-dioxygenase activity|lysine-2-oxoglutarate dioxygenase activity|lysyl hydroxylase activity|lysylprotocollagen dioxygenase activity|procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)|procollagen-lysine,2-oxoglutarate 5-dioxygenase activity|protocollagen lysine dioxygenase activity|protocollagen lysine hydroxylase activity|protocollagen lysyl hydroxylase activity http://purl.obolibrary.org/obo/GO_0008475 GO:0008474 biolink:MolecularActivity palmitoyl-(protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. EC:3.1.2.22|MetaCyc:3.1.2.22-RXN|RHEA:19233|Reactome:R-HSA-203613|Reactome:R-HSA-5690517|Reactome:R-HSA-8933328|Reactome:R-HSA-9647994 go.json palmitoyl-[protein] hydrolase|palmitoyl-protein hydrolase activity|palmitoyl-protein thioesterase activity|palmitoyl-protein thiolesterase activity http://purl.obolibrary.org/obo/GO_0008474 goslim_chembl GO:0008473 biolink:MolecularActivity ornithine cyclodeaminase activity Catalysis of the reaction: L-ornithine = L-proline + NH4. EC:4.3.1.12|KEGG_REACTION:R00671|MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN|RHEA:24368 go.json L-ornithine ammonia-lyase (cyclizing)|L-ornithine ammonia-lyase (cyclizing; L-proline-forming)|OCD activity|ornithine cyclase (deaminating) activity|ornithine cyclase activity http://purl.obolibrary.org/obo/GO_0008473 GO:0008472 biolink:MolecularActivity obsolete metallocarboxypeptidase D activity OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. go.json carboxypeptidase D (cattle, human, mouse, rat)|gp180 (duck)|metallocarboxypeptidase D activity True http://purl.obolibrary.org/obo/GO_0008472 GO:0008482 biolink:MolecularActivity sulfite oxidase activity Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate. EC:1.8.3.1|KEGG_REACTION:R00533|MetaCyc:PWY-5326|MetaCyc:SULFITE-OXIDASE-RXN|RHEA:24600|Reactome:R-HSA-1614544 go.json sulfite:oxygen oxidoreductase activity|sulphite oxidase activity http://purl.obolibrary.org/obo/GO_0008482 GO:0008481 biolink:MolecularActivity sphinganine kinase activity Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. EC:2.7.1.91|MetaCyc:SPHINGANINE-KINASE-RXN|RHEA:15465|Reactome:R-HSA-428214 go.json ATP:sphinganine 1-phosphotransferase activity|dihydrosphingosine kinase (phosphorylating)|dihydrosphingosine kinase activity|sphingosine kinase (phosphorylating)|sphingosine kinase activity http://purl.obolibrary.org/obo/GO_0008481 GO:0008480 biolink:MolecularActivity sarcosine dehydrogenase activity Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. EC:1.5.8.3|KEGG_REACTION:R00611|MetaCyc:SARCOSINE-DEHYDROGENASE-RXN|RHEA:19793|Reactome:R-HSA-6797913 go.json monomethylglycine dehydrogenase activity|sarcosine N-demethylase activity|sarcosine:(acceptor) oxidoreductase (demethylating)|sarcosine:acceptor oxidoreductase (demethylating) http://purl.obolibrary.org/obo/GO_0008480 GO:0033413 biolink:MolecularActivity UGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGU codon. go.json TGT codon-amino acid adaptor activity|cysteine tRNA http://purl.obolibrary.org/obo/GO_0033413 GO:0033412 biolink:MolecularActivity UAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAG codon. go.json TAG codon-amino acid adaptor activity http://purl.obolibrary.org/obo/GO_0033412 GO:0033411 biolink:MolecularActivity UAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAA codon. go.json TAA codon-amino acid adaptor activity http://purl.obolibrary.org/obo/GO_0033411 GO:0033410 biolink:MolecularActivity UAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAC codon. go.json TAC codon-amino acid adaptor activity|tyrosine tRNA http://purl.obolibrary.org/obo/GO_0033410 GO:0033394 biolink:BiologicalProcess beta-alanine biosynthetic process via 1,3 diaminopropane The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane. MetaCyc:PWY-3981 go.json beta-alanine anabolism via 1,3 diaminopropane|beta-alanine biosynthesis via 1,3 diaminopropane|beta-alanine formation via 1,3 diaminopropane|beta-alanine synthesis via 1,3 diaminopropane http://purl.obolibrary.org/obo/GO_0033394 GO:0033393 biolink:BiologicalProcess homogalacturonan catabolic process The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. MetaCyc:PWY-1081 go.json homogalacturonan breakdown|homogalacturonan catabolism|homogalacturonan degradation http://purl.obolibrary.org/obo/GO_0033393 GO:0033392 biolink:MolecularActivity obsolete actin homodimerization activity OBSOLETE. Binding to an identical actin monomer to form a homodimer. go.json actin dimerization activity|actin homodimerization activity|actin polymerizing activity True http://purl.obolibrary.org/obo/GO_0033392 GO:0033391 biolink:CellularComponent chromatoid body A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). go.json http://purl.obolibrary.org/obo/GO_0033391 GO:0033390 biolink:BiologicalProcess putrescine biosynthetic process from arginine via N-carbamoylputrescine The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps. go.json putrescine anabolism from arginine via N-carbamoylputrescine|putrescine biosynthesis from arginine via N-carbamoylputrescine|putrescine formation from arginine via N-carbamoylputrescine|putrescine synthesis from arginine via N-carbamoylputrescine http://purl.obolibrary.org/obo/GO_0033390 GO:0033399 biolink:BiologicalProcess cis-zeatin metabolic process The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. go.json cis-zeatin metabolism http://purl.obolibrary.org/obo/GO_0033399 GO:0033398 biolink:BiologicalProcess zeatin biosynthetic process The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. go.json zeatin anabolism|zeatin biosynthesis|zeatin formation|zeatin synthesis http://purl.obolibrary.org/obo/GO_0033398 GO:0033397 biolink:BiologicalProcess zeatin metabolic process The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. go.json zeatin metabolism http://purl.obolibrary.org/obo/GO_0033397 GO:0033396 biolink:BiologicalProcess beta-alanine biosynthetic process via 3-ureidopropionate The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate. MetaCyc:PWY-3982 go.json beta-alanine anabolism via 3-ureidopropionate|beta-alanine formation via 3-ureidopropionate|beta-alanine synthesis via 3-ureidopropionate http://purl.obolibrary.org/obo/GO_0033396 GO:0033395 biolink:BiologicalProcess beta-alanine biosynthetic process via 3-hydroxypropionate The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate. MetaCyc:PWY-3941 go.json beta-alanine anabolism via 3-hydroxypropionate|beta-alanine biosynthesis via 3-hydroxypropionate|beta-alanine formation via 3-hydroxypropionate|beta-alanine synthesis via 3-hydroxypropionate http://purl.obolibrary.org/obo/GO_0033395 GO:0033383 biolink:BiologicalProcess geranyl diphosphate metabolic process The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes. go.json geranyl diphosphate metabolism|geranyldiphosphate metabolic process http://purl.obolibrary.org/obo/GO_0033383 GO:0033382 biolink:BiologicalProcess maintenance of granzyme B location in T cell secretory granule A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere. go.json maintenance of granzyme B localization in T cell secretory granule|maintenance of granzyme B localization in T lymphocyte secretory granule|maintenance of granzyme B localization in T-cell secretory granule|maintenance of granzyme B localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033382 GO:0033381 biolink:BiologicalProcess establishment of granzyme B localization to T cell secretory granule The directed movement of the protease granzyme B to a location within a secretory granule in a T cell. go.json T-lymphocyte secretory granule storage of granzyme B|establishment of granzyme B localisation in T cell secretory granule|establishment of granzyme B localization in T cell secretory granule|establishment of granzyme B localization in T lymphocyte secretory granule|establishment of granzyme B localization in T-cell secretory granule|establishment of granzyme B localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033381 GO:0033380 biolink:BiologicalProcess granzyme B localization to T cell secretory granule Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell. go.json granzyme B localisation in T cell secretory granule|granzyme B localization in T cell secretory granule|granzyme B localization in T lymphocyte secretory granule|granzyme B localization in T-cell secretory granule|granzyme B localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033380 GO:0033389 biolink:BiologicalProcess putrescine biosynthetic process from arginine, using agmatinase The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step. go.json putrescine anabolism from arginine, using agmatinase|putrescine biosynthesis from arginine, using agmatinase|putrescine formation from arginine, using agmatinase|putrescine synthesis from arginine, using agmatinase http://purl.obolibrary.org/obo/GO_0033389 GO:0033388 biolink:BiologicalProcess putrescine biosynthetic process from arginine The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine. go.json putrescine anabolism from arginine|putrescine biosynthesis from arginine|putrescine formation from arginine|putrescine synthesis from arginine http://purl.obolibrary.org/obo/GO_0033388 GO:0033387 biolink:BiologicalProcess putrescine biosynthetic process from ornithine The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine. go.json putrescine anabolism from ornithine|putrescine biosynthesis from ornithine|putrescine formation from ornithine|putrescine synthesis from ornithine http://purl.obolibrary.org/obo/GO_0033387 GO:0033386 biolink:BiologicalProcess geranylgeranyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate. MetaCyc:PWY-5120|MetaCyc:PWY-5121 go.json geranylgeranyl diphosphate anabolism|geranylgeranyl diphosphate biosynthesis|geranylgeranyl diphosphate formation|geranylgeranyl diphosphate synthesis http://purl.obolibrary.org/obo/GO_0033386 GO:0033385 biolink:BiologicalProcess geranylgeranyl diphosphate metabolic process The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins. go.json geranylgeranyl diphosphate metabolism|geranylgeranyldiphosphate metabolic process http://purl.obolibrary.org/obo/GO_0033385 GO:0033384 biolink:BiologicalProcess geranyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of geranyl diphosphate. MetaCyc:PWY-5122 go.json geranyl diphosphate anabolism|geranyl diphosphate biosynthesis|geranyl diphosphate formation|geranyl diphosphate synthesis|geranyldiphosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0033384 GO:0033372 biolink:BiologicalProcess establishment of protease localization to mast cell secretory granule The directed movement of a protease to a location within a secretory granule in a mast cell. go.json establishment of protease localisation in mast cell secretory granule|establishment of protease localization in mast cell secretory granule http://purl.obolibrary.org/obo/GO_0033372 GO:0033371 biolink:BiologicalProcess T cell secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. go.json T cell secretory granule organisation|T cell secretory granule organization and biogenesis|T lymphocyte secretory granule organization|T-cell secretory granule organization|T-lymphocyte secretory granule maturation|T-lymphocyte secretory granule organization http://purl.obolibrary.org/obo/GO_0033371 GO:0033370 biolink:BiologicalProcess maintenance of protein location in mast cell secretory granule A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere. go.json maintenance of protein localization in mast cell secretory granule|mast cell protein retention http://purl.obolibrary.org/obo/GO_0033370 GO:0033379 biolink:BiologicalProcess maintenance of protease location in T cell secretory granule A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere. go.json maintenance of protease localization in T cell secretory granule|maintenance of protease localization in T lymphocyte secretory granule|maintenance of protease localization in T-cell secretory granule|maintenance of protease localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033379 GO:0033378 biolink:BiologicalProcess establishment of protease localization to T cell secretory granule The directed movement of a protease to a location within a secretory granule in a T cell. go.json establishment of protease localisation in T cell secretory granule|establishment of protease localization in T cell secretory granule|establishment of protease localization in T lymphocyte secretory granule|establishment of protease localization in T-cell secretory granule|establishment of protease localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033378 GO:0033377 biolink:BiologicalProcess maintenance of protein location in T cell secretory granule A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere. go.json maintenance of protein localization in T cell secretory granule|maintenance of protein localization in T lymphocyte secretory granule|maintenance of protein localization in T-cell secretory granule|maintenance of protein localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033377 GO:0033376 biolink:BiologicalProcess establishment of protein localization to T cell secretory granule The directed movement of a protein to a location within a secretory granule in a T cell. go.json establishment of protein localisation in T cell secretory granule|establishment of protein localization in T cell secretory granule|establishment of protein localization in T lymphocyte secretory granule|establishment of protein localization in T-cell secretory granule|establishment of protein localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033376 GO:0033375 biolink:BiologicalProcess protease localization to T cell secretory granule Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell. go.json protease localisation in T cell secretory granule|protease localization in T cell secretory granule|protease localization in T lymphocyte secretory granule|protease localization in T-cell secretory granule|protease localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033375 GO:0033374 biolink:BiologicalProcess protein localization to T cell secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell. go.json protein localisation in T cell secretory granule|protein localization in T cell secretory granule|protein localization in T lymphocyte secretory granule|protein localization in T-cell secretory granule|protein localization in T-lymphocyte secretory granule http://purl.obolibrary.org/obo/GO_0033374 GO:0033373 biolink:BiologicalProcess maintenance of protease location in mast cell secretory granule A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere. go.json maintenance of protease localization in mast cell secretory granule|mast cell protease retention http://purl.obolibrary.org/obo/GO_0033373 GO:0141105 biolink:BiologicalProcess symbiont-mediated suppression of host toll-like receptor signal transduction A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json symbiont-mediated disruption of host toll-like receptor signaling pathway|symbiont-mediated suppression of host toll-like receptor signaling pathway http://purl.obolibrary.org/obo/GO_0141105 GO:0141104 biolink:BiologicalProcess symbiont-mediated activation of host G protein-coupled receptor signal transduction A process in which a symbiont G protein-coupled receptor signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0141104 GO:0141101 biolink:MolecularActivity tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.211|MetaCyc:RXN-12368|RHEA:43100 go.json tRNA(Ser) (uracil(44)-2'-O-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0141101 GO:0141100 biolink:MolecularActivity tRNA (guanine(18)-2'-O)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 18 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 18 in tRNA + H+. EC:2.1.1.34|MetaCyc:2.1.1.34-RXN|RHEA:20077 go.json tRNA (guanosine(18)-2'-O)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0141100 GO:0141102 biolink:MolecularActivity tRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.207|RHEA:43088 go.json tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase activity http://purl.obolibrary.org/obo/GO_0141102 GO:0033529 biolink:BiologicalProcess raffinose biosynthetic process The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json raffinose anabolism|raffinose biosynthesis|raffinose formation|raffinose synthesis http://purl.obolibrary.org/obo/GO_0033529 GO:0033528 biolink:BiologicalProcess S-methylmethionine cycle A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level. MetaCyc:PWY-5441 go.json http://purl.obolibrary.org/obo/GO_0033528 GO:0033527 biolink:BiologicalProcess tetrapyrrole biosynthetic process from glycine and succinyl-CoA The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA. MetaCyc:PWY-5189 go.json tetrapyrrole anabolism from glycine and succinyl-CoA|tetrapyrrole biosynthesis from glycine and succinyl-CoA|tetrapyrrole formation from glycine and succinyl-CoA|tetrapyrrole synthesis from glycine and succinyl-CoA http://purl.obolibrary.org/obo/GO_0033527 GO:0033526 biolink:BiologicalProcess tetrapyrrole biosynthetic process from glutamate The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate. MetaCyc:PWY-5188 go.json tetrapyrrole anabolism from glutamate|tetrapyrrole biosynthesis from glutamate|tetrapyrrole formation from glutamate|tetrapyrrole synthesis from glutamate http://purl.obolibrary.org/obo/GO_0033526 GO:0008569 biolink:MolecularActivity minus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. go.json ATP-dependent microtubule motor activity, minus-end-directed|ATP-dependent minus-end-directed microtubule motor activity|dynein ATPase|kinesin ATP phosphohydrolase (minus-end-directed)|microtubule motor activity, minus-end-directed|minus-end-directed ATP-dependent microtubule motor activity|minus-end-directed kinesin ATPase activity http://purl.obolibrary.org/obo/GO_0008569 GO:0033525 biolink:BiologicalProcess sinapate ester biosynthetic process The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. MetaCyc:PWY-3301 go.json sinapate ester anabolism|sinapate ester biosynthesis|sinapate ester formation|sinapate ester synthesis http://purl.obolibrary.org/obo/GO_0033525 GO:0008568 biolink:MolecularActivity microtubule severing ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. EC:5.6.1.1|MetaCyc:3.6.4.3-RXN|Reactome:R-HSA-9668419 go.json ATP phosphohydrolase (tubulin-dimerizing)|katanin activity|microtubule-severing ATPase activity http://purl.obolibrary.org/obo/GO_0008568 GO:0033524 biolink:BiologicalProcess sinapate ester metabolic process The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. go.json sinapate ester metabolism http://purl.obolibrary.org/obo/GO_0033524 GO:0008567 biolink:MolecularActivity obsolete dynein ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome. go.json dynein ATPase activity True http://purl.obolibrary.org/obo/GO_0008567 GO:0008566 biolink:MolecularActivity mitochondrial protein-transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex. EC:7.4.2.3|MetaCyc:3.6.3.51-RXN go.json ATPase-coupled mitochondrial protein transporter activity http://purl.obolibrary.org/obo/GO_0008566 GO:0008565 biolink:MolecularActivity obsolete protein transporter activity OBSOLETE. Enables the directed movement of proteins into, out of or within a cell, or between cells. go.json enzyme transporter activity|holin|protein transport chaperone|secretin True http://purl.obolibrary.org/obo/GO_0008565 GO:0008564 biolink:MolecularActivity protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins. EC:7.4.2.8|MetaCyc:3.6.3.50-RXN go.json ATPase-coupled protein transporter activity http://purl.obolibrary.org/obo/GO_0008564 GO:0008563 biolink:MolecularActivity obsolete alpha-factor sex pheromone exporter OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. go.json alpha-factor sex pheromone exporter|alpha-factor-transporting ATPase True http://purl.obolibrary.org/obo/GO_0008563 GO:0008562 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008562 GO:0008561 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008561 GO:0008560 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008560 GO:0008570 biolink:MolecularActivity obsolete myosin ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction. go.json myosin ATPase activity True http://purl.obolibrary.org/obo/GO_0008570 GO:0033523 biolink:BiologicalProcess histone H2B ubiquitination The modification of histone H2B by addition of ubiquitin groups. go.json http://purl.obolibrary.org/obo/GO_0033523 gocheck_do_not_annotate GO:0033522 biolink:BiologicalProcess histone H2A ubiquitination The modification of histone H2A by addition of one or more ubiquitin groups. go.json http://purl.obolibrary.org/obo/GO_0033522 gocheck_do_not_annotate GO:0033521 biolink:BiologicalProcess phytyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate. MetaCyc:PWY-5063 go.json phytyl diphosphate anabolism|phytyl diphosphate biosynthesis|phytyl diphosphate formation|phytyl diphosphate synthesis http://purl.obolibrary.org/obo/GO_0033521 GO:0033520 biolink:BiologicalProcess phytol biosynthetic process The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol. go.json phytol anabolism|phytol biosynthesis|phytol formation|phytol synthesis http://purl.obolibrary.org/obo/GO_0033520 GO:0033519 biolink:BiologicalProcess phytyl diphosphate metabolic process The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate. go.json phytyl diphosphate metabolism http://purl.obolibrary.org/obo/GO_0033519 GO:0033518 biolink:BiologicalProcess obsolete myo-inositol hexakisphosphate dephosphorylation OBSOLETE. The process of removing one or more phosphate group from myo-inositol hexakisphosphate. go.json phytate dephosphorylation True http://purl.obolibrary.org/obo/GO_0033518 GO:0033517 biolink:BiologicalProcess myo-inositol hexakisphosphate metabolic process The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. go.json myo-inositol hexakisphosphate metabolism|phytate metabolic process|phytate metabolism http://purl.obolibrary.org/obo/GO_0033517 GO:0033516 biolink:BiologicalProcess L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine. MetaCyc:PWY-702 go.json L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine|L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine|L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine|methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine http://purl.obolibrary.org/obo/GO_0033516 GO:0033515 biolink:BiologicalProcess L-lysine catabolic process using lysine 6-aminotransferase The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase. MetaCyc:PWY-5298 go.json L-lysine breakdown using lysine 6-aminotransferase|L-lysine degradation using lysine 6-aminotransferase http://purl.obolibrary.org/obo/GO_0033515 GO:0033514 biolink:BiologicalProcess L-lysine catabolic process to acetyl-CoA via L-pipecolate The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate. MetaCyc:PWY-5283 go.json L-lysine breakdown to acetyl-CoA via L-pipecolate|L-lysine degradation to acetyl-CoA via L-pipecolate http://purl.obolibrary.org/obo/GO_0033514 GO:0033513 biolink:BiologicalProcess L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide. MetaCyc:PWY-5280 go.json L-lysine breakdown to acetyl-CoA via 5-aminopentanamide|L-lysine degradation to acetyl-CoA via 5-aminopentanamide http://purl.obolibrary.org/obo/GO_0033513 GO:0008579 biolink:MolecularActivity JUN kinase phosphatase activity Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. go.json http://purl.obolibrary.org/obo/GO_0008579 GO:0008578 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008578 GO:0008577 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008577 GO:0008576 biolink:MolecularActivity obsolete vesicle-fusing ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. go.json vesicle-fusing ATPase activity True http://purl.obolibrary.org/obo/GO_0008576 GO:0008575 biolink:MolecularActivity obsolete proteasome ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome. go.json proteasome ATPase activity True http://purl.obolibrary.org/obo/GO_0008575 GO:0008574 biolink:MolecularActivity plus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. EC:5.6.1.3|MetaCyc:3.6.4.4-RXN go.json ATP-dependent microtubule motor activity, plus-end-directed|ATP-dependent plus-end-directed microtubule motor activity|kinesin ATP phosphohydrolase (plus-end-directed)|kinesin activity|microtubule motor activity, plus-end-directed|plus-end-directed ATP-dependent microtubule motor activity|plus-end-directed kinesin ATPase activity http://purl.obolibrary.org/obo/GO_0008574 GO:0008573 biolink:MolecularActivity obsolete peroxisome-assembly ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle. go.json peroxisome-assembly ATPase activity True http://purl.obolibrary.org/obo/GO_0008573 GO:0008572 biolink:MolecularActivity obsolete nucleoplasmin ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes. go.json nucleoplasmin ATPase activity True http://purl.obolibrary.org/obo/GO_0008572 GO:0008571 biolink:MolecularActivity obsolete non-chaperonin molecular chaperone ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin. go.json non-chaperonin molecular chaperone ATPase activity True http://purl.obolibrary.org/obo/GO_0008571 GO:0008581 biolink:MolecularActivity obsolete ubiquitin-specific protease 5 activity OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin. go.json ubiquitin isopeptidase T activity|ubiquitin-specific protease 5 activity True http://purl.obolibrary.org/obo/GO_0008581 GO:0008580 biolink:MolecularActivity obsolete cytoskeletal regulator activity OBSOLETE. (Was not defined before being made obsolete). go.json cytoskeletal regulator activity True http://purl.obolibrary.org/obo/GO_0008580 GO:0033512 biolink:BiologicalProcess L-lysine catabolic process to acetyl-CoA via saccharopine The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine. MetaCyc:LYSINE-DEG1-PWY go.json L-lysine breakdown to acetyl-CoA via saccharopine|L-lysine degradation to acetyl-CoA via saccharopine http://purl.obolibrary.org/obo/GO_0033512 GO:0033511 biolink:BiologicalProcess luteolin biosynthetic process The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one. MetaCyc:PWY-5060 go.json luteolin anabolism|luteolin biosynthesis|luteolin formation|luteolin synthesis http://purl.obolibrary.org/obo/GO_0033511 GO:0033510 biolink:BiologicalProcess luteolin metabolic process The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one. go.json luteolin metabolism http://purl.obolibrary.org/obo/GO_0033510 GO:0033509 biolink:BiologicalProcess glutamate catabolic process to propionate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate. MetaCyc:PWY-5088 go.json glutamate breakdown to propionate|glutamate degradation to propionate http://purl.obolibrary.org/obo/GO_0033509 GO:0033508 biolink:BiologicalProcess glutamate catabolic process to butyrate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate. MetaCyc:PWY-5087 go.json glutamate breakdown to butyrate|glutamate degradation to butyrate http://purl.obolibrary.org/obo/GO_0033508 GO:0033507 biolink:BiologicalProcess glucosinolate biosynthetic process from phenylalanine The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine. MetaCyc:PWY-2821 go.json glucosinolate anabolism from phenylalanine|glucosinolate biosynthesis from phenylalanine|glucosinolate formation from phenylalanine|glucosinolate synthesis from phenylalanine http://purl.obolibrary.org/obo/GO_0033507 GO:0033506 biolink:BiologicalProcess glucosinolate biosynthetic process from homomethionine The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine. MetaCyc:PWY-1187 go.json glucosinolate anabolism from homomethionine|glucosinolate biosynthesis from homomethionine|glucosinolate formation from homomethionine|glucosinolate synthesis from homomethionine http://purl.obolibrary.org/obo/GO_0033506 GO:0008549 biolink:MolecularActivity obsolete dynamin GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles. go.json dynamin GTPase activity|dynamine GTPase activity True http://purl.obolibrary.org/obo/GO_0008549 GO:0033505 biolink:BiologicalProcess floor plate morphogenesis The process in which the anatomical structure of the floor plate is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0033505 GO:0033504 biolink:BiologicalProcess floor plate development The progression of the floor plate over time from its initial formation until its mature state. go.json http://purl.obolibrary.org/obo/GO_0033504 GO:0008548 biolink:MolecularActivity obsolete signal-recognition-particle GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis. go.json signal-recognition-particle GTPase activity True http://purl.obolibrary.org/obo/GO_0008548 GO:0033503 biolink:CellularComponent HULC complex A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2. go.json http://purl.obolibrary.org/obo/GO_0033503 GO:0008547 biolink:MolecularActivity obsolete protein-synthesizing GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs. go.json protein-synthesizing GTPase activity True http://purl.obolibrary.org/obo/GO_0008547 GO:0008546 biolink:BiologicalProcess obsolete microtubule/chromatin interaction OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins. go.json microtubule/chromatin interaction True http://purl.obolibrary.org/obo/GO_0008546 GO:0033502 biolink:BiologicalProcess obsolete intracellular galactose homeostasis OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of galactose within a cell. go.json cell galactose homeostasis|cellular galactose homeostasis True http://purl.obolibrary.org/obo/GO_0033502 GO:0008545 biolink:MolecularActivity JUN kinase kinase activity Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. Reactome:R-HSA-168162 go.json JNKK http://purl.obolibrary.org/obo/GO_0008545 GO:0008544 biolink:BiologicalProcess epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. go.json hypodermis development http://purl.obolibrary.org/obo/GO_0008544 GO:0008543 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. go.json FGF receptor signaling pathway|FGF receptor signalling pathway|FGFR signaling pathway|fibroblast growth factor receptor signalling pathway http://purl.obolibrary.org/obo/GO_0008543 GO:0008542 biolink:BiologicalProcess visual learning Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. go.json spatial learning http://purl.obolibrary.org/obo/GO_0008542 GO:0008541 biolink:CellularComponent proteasome regulatory particle, lid subcomplex The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. go.json http://purl.obolibrary.org/obo/GO_0008541 GO:0008540 biolink:CellularComponent proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. go.json http://purl.obolibrary.org/obo/GO_0008540 GO:0033501 biolink:BiologicalProcess obsolete galactose homeostasis OBSOLETE. A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell. go.json True http://purl.obolibrary.org/obo/GO_0033501 GO:0033500 biolink:BiologicalProcess carbohydrate homeostasis A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0033500 GO:0008559 biolink:MolecularActivity ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). EC:7.6.2.2|MetaCyc:3.6.3.44-RXN|Reactome:R-HSA-9757139 go.json ATP phosphohydrolase (xenobiotic-exporting)|ATP-dependent xenobiotic transmembrane transporter activity|ATPase-coupled xenobiotic transmembrane transporter activity|MDR protein|P-glycoprotein|PDR protein|multidrug resistance exporter|multidrug-resistance protein|pleiotropic-drug-resistance protein|xenobiotic ABC transporter|xenobiotic transmembrane transporting ATPase activity http://purl.obolibrary.org/obo/GO_0008559 GO:0008558 biolink:MolecularActivity ABC-type guanine transporter activity Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in). EC:7.6.2.6|MetaCyc:3.6.3.37-RXN|RHEA:20832 go.json ATP-dependent guanine transmembrane transporter activity|ATPase-coupled guanine transmembrane transporter activity|guanine ABC transporter|guanine-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0008558 GO:0008557 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008557 GO:0008556 biolink:MolecularActivity P-type potassium transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). EC:7.2.2.6|RHEA:16777 go.json ATP phosphohydrolase (K+-importing)|ATP-dependent potassium transmembrane transporter activity|ATPase-coupled potassium transmembrane transporter activity|K(+)-importing ATPase activity|K(+)-transporting ATPase activity|K+-importing ATPase activity|K+-transporting ATPase activity|potassium ABC transporter|potassium transmembrane transporter activity, phosphorylative mechanism|potassium transporting ATPase activity|potassium-importing ATPase activity|potassium-transporting ATPase activity|potassium-uptake-ATPase activity http://purl.obolibrary.org/obo/GO_0008556 GO:0008555 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008555 GO:0008554 biolink:MolecularActivity P-type sodium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism. EC:7.2.2.3|MetaCyc:RXN-17739|RHEA:14633 go.json Na(+)-exporting ATPase activity|Na(+)-transporting ATPase activity|Na+-exporting ATPase activity|Na+-transporting ATPase activity|sodium exporting ATPase activity, phosphorylative mechanism|sodium transmembrane transporter activity, phosphorylative mechanism|sodium transport ATPase activity|sodium-exporting ATPase activity|sodium-exporting ATPase activity, phosphorylative mechanism|sodium-translocating P-type ATPase activity http://purl.obolibrary.org/obo/GO_0008554 GO:0008553 biolink:MolecularActivity P-type proton-exporting transporter activity Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. EC:7.1.2.1|MetaCyc:3.6.3.6-RXN|RHEA:20852 go.json H+-exporting ATPase activity|H+-transporting ATPase|H+-transporting ATPase activity|P-type H+-exporting ATPase activity|hydrogen exporting ATPase activity, phosphorylative mechanism|hydrogen-/sodium-translocating ATPase activity|hydrogen-exporting ATPase activity|hydrogen-exporting ATPase activity, phosphorylative mechanism|proton transport ATPase activity|proton-exporting ATPase activity|proton-exporting ATPase activity, phosphorylative mechanism|proton-translocating ATPase activity|proton-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0008553 GO:0008552 biolink:MolecularActivity obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+. go.json zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity True http://purl.obolibrary.org/obo/GO_0008552 GO:0008551 biolink:MolecularActivity P-type cadmium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out). EC:7.2.2.21|MetaCyc:3.6.3.3-RXN|RHEA:12132 go.json Cd(2+)-exporting ATPase activity|Cd2+-exporting ATPase activity|cadmium exporting ATPase activity|cadmium transmembrane transporter activity, phosphorylative mechanism|cadmium-exporting ATPase activity|cadmium-translocating P-type ATPase activity http://purl.obolibrary.org/obo/GO_0008551 GO:0008550 biolink:MolecularActivity obsolete tubulin GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others. go.json tubulin GTPase activity True http://purl.obolibrary.org/obo/GO_0008550 GO:0008529 biolink:MolecularActivity obsolete endogenous peptide receptor activity OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity. go.json endogenous peptide receptor activity True http://purl.obolibrary.org/obo/GO_0008529 GO:0008528 biolink:MolecularActivity G protein-coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled peptide receptor activity|G-protein coupled peptide receptor activity|peptide receptor activity, G protein coupled|peptide receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0008528 GO:0008527 biolink:MolecularActivity taste receptor activity Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. go.json gustatory receptor http://purl.obolibrary.org/obo/GO_0008527 GO:0008526 biolink:MolecularActivity phosphatidylinositol transfer activity Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Reactome:R-HSA-8869241|Reactome:R-HSA-8874470 go.json intermembrane phosphatidylinositol transfer activity|intermembrane phosphotidylinositol transfer activity|phosphatidylinositol carrier activity|phosphatidylinositol transporter activity http://purl.obolibrary.org/obo/GO_0008526 GO:0008525 biolink:MolecularActivity phosphatidylcholine transporter activity Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. go.json phosphatidylcholine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0008525 GO:0008524 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008524 GO:0008523 biolink:MolecularActivity sodium-dependent multivitamin transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. Reactome:R-HSA-199206|Reactome:R-HSA-199219|Reactome:R-HSA-429581 go.json http://purl.obolibrary.org/obo/GO_0008523 GO:0008522 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008522 GO:0008521 biolink:MolecularActivity acetyl-CoA transmembrane transporter activity Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. Reactome:R-HSA-5649742|Reactome:R-HSA-727759 go.json acetyl-CoA transporter activity http://purl.obolibrary.org/obo/GO_0008521 GO:0008520 biolink:MolecularActivity L-ascorbate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). TC:2.A.40.6.1 go.json sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent L-ascorbic acid transporter http://purl.obolibrary.org/obo/GO_0008520 GO:0008539 biolink:MolecularActivity obsolete proteasome inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis. go.json PI-31|proteasome inhibitor activity True http://purl.obolibrary.org/obo/GO_0008539 GO:0008538 biolink:MolecularActivity obsolete proteasome activator activity OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis. go.json PA28|proteasome activator activity True http://purl.obolibrary.org/obo/GO_0008538 GO:0008537 biolink:CellularComponent proteasome activator complex A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. go.json PA28 http://purl.obolibrary.org/obo/GO_0008537 GO:0008536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008536 GO:0008535 biolink:BiologicalProcess respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. go.json cytochrome c oxidase biogenesis|cytochrome c oxidase complex assembly http://purl.obolibrary.org/obo/GO_0008535 GO:0008534 biolink:MolecularActivity oxidized purine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. EC:3.2.2.23|MetaCyc:3.2.2.23-RXN|Reactome:R-HSA-110229|Reactome:R-HSA-110243|Reactome:R-HSA-110244 go.json 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity|2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity|8-oxoguanine DNA glycosylase activity|DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]|DNA glycosylase/AP-lyase activity|DNA glycosylase/beta-lyase activity|DNA-formamidopyrimidine glycosylase activity|Fapy-DNA glycosylase activity|Fpg protein|bifunctional DNA glycosylase activity|deoxyribonucleate glycosidase activity|formamidopyrimidine-DNA glycosylase activity|oxidized purine base lesion DNA N-glycosylase activity|purine-specific oxidized base lesion DNA N-glycosylase activity http://purl.obolibrary.org/obo/GO_0008534 GO:0008533 biolink:MolecularActivity obsolete astacin activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'. go.json Astacus proteinase activity|astacin activity|astacus proteinase activity|crayfish small-molecule proteinase activity True http://purl.obolibrary.org/obo/GO_0008533 GO:0008532 biolink:MolecularActivity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. EC:2.4.1.149|MetaCyc:2.4.1.149-RXN|RHEA:14389|Reactome:R-HSA-2025724 go.json GnTE activity|N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity|UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity|UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity|UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity|galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity|poly-N-acetyllactosamine extension enzyme activity|uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase|uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase http://purl.obolibrary.org/obo/GO_0008532 GO:0008531 biolink:MolecularActivity riboflavin kinase activity Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+. EC:2.7.1.26|KEGG_REACTION:R00549|MetaCyc:RIBOFLAVINKIN-RXN|RHEA:14357|Reactome:R-HSA-196964 go.json ATP:riboflavin 5'-phosphotransferase activity|FK|flavokinase activity|riboflavin kinase (phosphorylating)|riboflavine kinase activity http://purl.obolibrary.org/obo/GO_0008531 GO:0008530 biolink:MolecularActivity obsolete exogenous peptide receptor activity OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity. go.json exogenous peptide receptor activity True http://purl.obolibrary.org/obo/GO_0008530 GO:0008509 biolink:MolecularActivity monoatomic anion transmembrane transporter activity Enables the transfer of a negatively charged ion from one side of a membrane to the other. Reactome:R-HSA-166214 go.json anion transmembrane transporter activity|anion transporter activity http://purl.obolibrary.org/obo/GO_0008509 GO:0008508 biolink:MolecularActivity bile acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). Reactome:R-HSA-194121|Reactome:R-HSA-194187|Reactome:R-HSA-433089 go.json sodium/bile acid symporter activity http://purl.obolibrary.org/obo/GO_0008508 GO:0008507 biolink:MolecularActivity sodium:iodide symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). Reactome:R-HSA-429591|Reactome:R-HSA-5658195 go.json sodium/iodide symporter activity http://purl.obolibrary.org/obo/GO_0008507 GO:0008506 biolink:MolecularActivity sucrose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in). go.json hydrogen/sucrose transporter activity|sucrose:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0008506 GO:0008505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008505 GO:0008504 biolink:MolecularActivity monoamine transmembrane transporter activity Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. Reactome:R-HSA-372542|Reactome:R-HSA-379393|Reactome:R-HSA-380586|Reactome:R-HSA-380620|Reactome:R-HSA-444160|Reactome:R-HSA-5660706 go.json http://purl.obolibrary.org/obo/GO_0008504 GO:0008503 biolink:MolecularActivity benzodiazepine receptor activity Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0008503 GO:0008502 biolink:MolecularActivity melatonin receptor activity Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. go.json http://purl.obolibrary.org/obo/GO_0008502 GO:0008501 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008501 GO:0008500 biolink:MolecularActivity obsolete glycine-, glutamate-, thienylcyclohexylpiperidine binding OBSOLETE. (Was not defined before being made obsolete). go.json glycine-, glutamate-, thienylcyclohexylpiperidine binding True http://purl.obolibrary.org/obo/GO_0008500 GO:0008519 biolink:MolecularActivity ammonium transmembrane transporter activity Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. RHEA:28747|Reactome:R-HSA-444393|Reactome:R-HSA-444416|Reactome:R-HSA-444419|Reactome:R-HSA-446277|Reactome:R-HSA-446278|Reactome:R-HSA-5623051|TC:1.A.11 go.json ammonia transmembrane transporter activity|ammonium channel activity http://purl.obolibrary.org/obo/GO_0008519 GO:0008518 biolink:MolecularActivity folate:monoatomic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF. TC:2.A.48 go.json folate:anion antiporter activity|reduced folate carrier activity|reduced folate transmembrane transporter activity|reduced folate transporter http://purl.obolibrary.org/obo/GO_0008518 GO:0008517 biolink:MolecularActivity folic acid transmembrane transporter activity Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. Reactome:R-HSA-200646|Reactome:R-HSA-200652|Reactome:R-HSA-200680|Reactome:R-HSA-200720|Reactome:R-HSA-200729 go.json folate transmembrane transporter activity|folate transporter activity|folic acid transporter activity|vitamin B9 transporter activity|vitamin M transporter activity http://purl.obolibrary.org/obo/GO_0008517 GO:0008516 biolink:MolecularActivity hexose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in). go.json http://purl.obolibrary.org/obo/GO_0008516 GO:0008515 biolink:MolecularActivity sucrose transmembrane transporter activity Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. go.json sucrose permease (PTS) activity|sucrose permease activity http://purl.obolibrary.org/obo/GO_0008515 GO:0008514 biolink:MolecularActivity organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. Reactome:R-HSA-2142859|Reactome:R-HSA-561041|Reactome:R-HSA-9794830 go.json http://purl.obolibrary.org/obo/GO_0008514 GO:0008513 biolink:MolecularActivity secondary active organic cation transmembrane transporter activity Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. Reactome:R-HSA-549241 go.json organic cation porter activity|polyspecific organic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0008513 GO:0008512 biolink:MolecularActivity sulfate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). go.json sulfate/hydrogen symporter activity|sulfate:hydrogen symporter activity|sulphate:hydrogen symporter activity http://purl.obolibrary.org/obo/GO_0008512 GO:0008511 biolink:MolecularActivity sodium:potassium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). Reactome:R-HSA-426086|Reactome:R-HSA-5623588 go.json sodium/potassium/chloride symporter activity http://purl.obolibrary.org/obo/GO_0008511 GO:0008510 biolink:MolecularActivity sodium:bicarbonate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). Reactome:R-HSA-425483|Reactome:R-HSA-5656219|Reactome:R-HSA-8878664 go.json sodium/bicarbonate cotransporter activity|sodium:bicarbonate cotransporter activity http://purl.obolibrary.org/obo/GO_0008510 GO:0033592 biolink:MolecularActivity RNA strand annealing activity An activity that facilitates the formation of a complementary double-stranded RNA molecule. go.json http://purl.obolibrary.org/obo/GO_0033592 GO:0033591 biolink:BiologicalProcess response to L-ascorbic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. go.json response to L-ascorbate|response to ascorbic acid|response to vitamin C http://purl.obolibrary.org/obo/GO_0033591 GO:0033590 biolink:BiologicalProcess response to cobalamin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. go.json response to vitamin B12 http://purl.obolibrary.org/obo/GO_0033590 GO:0033599 biolink:BiologicalProcess regulation of mammary gland epithelial cell proliferation Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0033599 GO:0033598 biolink:BiologicalProcess mammary gland epithelial cell proliferation The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. go.json http://purl.obolibrary.org/obo/GO_0033598 GO:0033597 biolink:CellularComponent mitotic checkpoint complex A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. go.json MCC http://purl.obolibrary.org/obo/GO_0033597 GO:0033596 biolink:CellularComponent TSC1-TSC2 complex A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. go.json tuberin-hamartin complex|tuberous sclerosis complex http://purl.obolibrary.org/obo/GO_0033596 GO:0033595 biolink:BiologicalProcess response to genistein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. go.json http://purl.obolibrary.org/obo/GO_0033595 GO:0033594 biolink:BiologicalProcess response to hydroxyisoflavone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus. go.json http://purl.obolibrary.org/obo/GO_0033594 GO:0033593 biolink:CellularComponent BRCA2-MAGE-D1 complex A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth. go.json http://purl.obolibrary.org/obo/GO_0033593 GO:0033581 biolink:BiologicalProcess obsolete protein galactosylation in Golgi OBSOLETE. The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus. go.json protein amino acid galactosylation in Golgi True http://purl.obolibrary.org/obo/GO_0033581 GO:0033580 biolink:BiologicalProcess obsolete protein galactosylation at cell surface OBSOLETE. The addition of a galactose unit to a protein amino acid at the surface of a cell. go.json protein amino acid galactosylation at cell surface True http://purl.obolibrary.org/obo/GO_0033580 GO:0033589 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033589 GO:0033588 biolink:CellularComponent elongator holoenzyme complex A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. go.json Elongator core complex http://purl.obolibrary.org/obo/GO_0033588 GO:0033587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033587 GO:0033586 biolink:BiologicalProcess L-phenylalanine biosynthetic process from chorismate via L-arogenate The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate. MetaCyc:PWY-3462 go.json L-phenylalanine anabolism from chorismate via L-arogenate|L-phenylalanine biosynthesis from chorismate via L-arogenate|L-phenylalanine formation from chorismate via L-arogenate|L-phenylalanine synthesis from chorismate via L-arogenate http://purl.obolibrary.org/obo/GO_0033586 GO:0033585 biolink:BiologicalProcess L-phenylalanine biosynthetic process from chorismate via phenylpyruvate The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate. MetaCyc:PHESYN go.json L-phenylalanine anabolism from chorismate via phenylpyruvate|L-phenylalanine biosynthesis from chorismate via phenylpyruvate|L-phenylalanine formation from chorismate via phenylpyruvate|L-phenylalanine synthesis from chorismate via phenylpyruvate http://purl.obolibrary.org/obo/GO_0033585 GO:0033584 biolink:BiologicalProcess tyrosine biosynthetic process from chorismate via L-arogenate The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate. MetaCyc:PWY-3461 go.json tyrosine anabolism from chorismate via L-arogenate|tyrosine formation from chorismate via L-arogenate|tyrosine synthesis from chorismate via L-arogenate http://purl.obolibrary.org/obo/GO_0033584 GO:0033583 biolink:CellularComponent rhabdomere membrane The portion of the plasma membrane surrounding the rhabdomere. go.json http://purl.obolibrary.org/obo/GO_0033583 GO:0033582 biolink:BiologicalProcess obsolete protein galactosylation in cytosol OBSOLETE. The addition of a galactose unit to a protein amino acid in the cytosol. go.json protein amino acid galactosylation in cytosol True http://purl.obolibrary.org/obo/GO_0033582 GO:0033579 biolink:BiologicalProcess obsolete protein galactosylation in endoplasmic reticulum OBSOLETE. The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum. go.json protein amino acid galactosylation in ER|protein amino acid galactosylation in endoplasmic reticulum True http://purl.obolibrary.org/obo/GO_0033579 GO:0033570 biolink:MolecularActivity obsolete transferrin transmembrane transporter activity OBSOLETE. Enables the transfer of transferrin from one side of a membrane to the other. go.json True http://purl.obolibrary.org/obo/GO_0033570 GO:0033578 biolink:BiologicalProcess obsolete protein glycosylation in Golgi OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus. go.json protein amino acid glycosylation in Golgi|terminal glycosylation True http://purl.obolibrary.org/obo/GO_0033578 GO:0033577 biolink:BiologicalProcess obsolete protein glycosylation in endoplasmic reticulum OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum. go.json core glycosylation|protein amino acid glycosylation in ER|protein amino acid glycosylation in endoplasmic reticulum True http://purl.obolibrary.org/obo/GO_0033577 GO:0033576 biolink:BiologicalProcess obsolete protein glycosylation in cytosol OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol. go.json protein amino acid glycosylation in cytosol True http://purl.obolibrary.org/obo/GO_0033576 GO:0033575 biolink:BiologicalProcess obsolete protein glycosylation at cell surface OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid at the surface of a cell. go.json protein amino acid glycosylation at cell surface True http://purl.obolibrary.org/obo/GO_0033575 GO:0033574 biolink:BiologicalProcess response to testosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. go.json response to testosterone stimulus http://purl.obolibrary.org/obo/GO_0033574 GO:0033573 biolink:CellularComponent high-affinity iron permease complex A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity iron permease complex http://purl.obolibrary.org/obo/GO_0033573 GO:0033572 biolink:BiologicalProcess transferrin transport The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json melanotransferrin transport http://purl.obolibrary.org/obo/GO_0033572 GO:0033571 biolink:BiologicalProcess lactoferrin transport The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0033571 GO:0033569 biolink:MolecularActivity lactoferrin transmembrane transporter activity Enables the transfer of lactoferrin from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0033569 GO:0033568 biolink:MolecularActivity lactoferrin receptor activity Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH. go.json http://purl.obolibrary.org/obo/GO_0033568 GO:0033567 biolink:BiologicalProcess DNA replication, Okazaki fragment processing The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand. go.json http://purl.obolibrary.org/obo/GO_0033567 GO:0033566 biolink:BiologicalProcess gamma-tubulin complex localization Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location. go.json establishment and maintenance of gamma-tubulin complex localization|gamma-tubulin complex localisation http://purl.obolibrary.org/obo/GO_0033566 GO:0033565 biolink:CellularComponent ESCRT-0 complex A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals. go.json Hrs/STAM complex|Vps27p-Hse1p complex http://purl.obolibrary.org/obo/GO_0033565 GO:0033564 biolink:BiologicalProcess anterior/posterior axon guidance The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. go.json anterior-posterior axon guidance|anterior/posterior axon pathfinding http://purl.obolibrary.org/obo/GO_0033564 GO:0033563 biolink:BiologicalProcess dorsal/ventral axon guidance The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. go.json dorsal-ventral axon guidance|dorsal/ventral axon pathfinding|dorsoventral axon guidance http://purl.obolibrary.org/obo/GO_0033563 GO:0033562 biolink:BiologicalProcess co-transcriptional gene silencing by RNA interference machinery A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin. go.json RNAi-mediated CTGS|co-transcriptional gene silencing by small RNA|cotranscriptional gene silencing by RNA interference machinery|cotranscriptional gene silencing by small RNA|small RNA-mediated cotranscriptional gene silencing http://purl.obolibrary.org/obo/GO_0033562 GO:0033561 biolink:BiologicalProcess obsolete regulation of water loss via skin OBSOLETE. A process that modulates the rate or extent of water loss from an organism via the skin. go.json skin barrier function True http://purl.obolibrary.org/obo/GO_0033561 GO:0033560 biolink:MolecularActivity folate reductase activity Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+. RHEA:31103|Reactome:R-HSA-197963|Reactome:R-HSA-197972|Reactome:R-HSA-9709098 go.json http://purl.obolibrary.org/obo/GO_0033560 GO:0033559 biolink:BiologicalProcess unsaturated fatty acid metabolic process The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. MetaCyc:PWY-762|MetaCyc:PWY-782 go.json unsaturated fatty acid metabolism http://purl.obolibrary.org/obo/GO_0033559 GO:0033558 biolink:MolecularActivity protein lysine deacetylase activity Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. RHEA:58108|Reactome:R-HSA-5693092|Reactome:R-HSA-8952069|Reactome:R-HSA-9626962|Reactome:R-HSA-9701565 go.json protein deacetylase activity http://purl.obolibrary.org/obo/GO_0033558 GO:0033557 biolink:CellularComponent Slx1-Slx4 complex A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes. go.json http://purl.obolibrary.org/obo/GO_0033557 GO:0033556 biolink:MolecularActivity dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol. go.json dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0033556 GO:0033555 biolink:BiologicalProcess multicellular organismal response to stress Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0033555 GO:0033554 biolink:BiologicalProcess cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). go.json http://purl.obolibrary.org/obo/GO_0033554 gocheck_do_not_manually_annotate GO:0033553 biolink:CellularComponent rDNA heterochromatin A region of heterochromatin located at the rDNA repeats in a chromosome. go.json nuclear rDNA heterochromatin|ribosomal DNA heterochromatin|ribosomal DNA heterochromatin of cell nucleus|ribosomal DNA heterochromatin of nucleus http://purl.obolibrary.org/obo/GO_0033553 GO:0033552 biolink:BiologicalProcess response to vitamin B3 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus. go.json response to niacin|response to nicotinamide http://purl.obolibrary.org/obo/GO_0033552 GO:0033551 biolink:CellularComponent monopolin complex A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits. go.json Pcs1/Mde4 complex|monopolin subcomplex Csm1/Lrs4 http://purl.obolibrary.org/obo/GO_0033551 GO:0033550 biolink:MolecularActivity MAP kinase tyrosine phosphatase activity Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate. go.json tyrosine-specific MAP kinase phosphatase activity http://purl.obolibrary.org/obo/GO_0033550 GO:0033549 biolink:MolecularActivity MAP kinase phosphatase activity Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. go.json MAPK phosphatase activity http://purl.obolibrary.org/obo/GO_0033549 GO:0033548 biolink:BiologicalProcess myo-inositol hexakisphosphate biosynthetic process, lipid-independent The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate. MetaCyc:PWY-4661 go.json myo-inositol hexakisphosphate anabolism, lipid-independent|myo-inositol hexakisphosphate biosynthesis, lipid-independent|myo-inositol hexakisphosphate formation, lipid-independent|myo-inositol hexakisphosphate synthesis, lipid-independent|phytate biosynthesis, lipid-independent|phytate biosynthetic process, lipid-independent http://purl.obolibrary.org/obo/GO_0033548 GO:0033547 biolink:BiologicalProcess obsolete myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate OBSOLETE. The chemical reactions and pathways resulting in the formation of 1D myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate. MetaCyc:PWY-4541 go.json myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate|myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate|myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate|myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate|myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate|phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate|phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate True http://purl.obolibrary.org/obo/GO_0033547 GO:0033546 biolink:BiologicalProcess myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further. MetaCyc:PWY-6554 go.json myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate|phytate biosynthesis, via inositol 1,3,4-trisphosphate|phytate biosynthetic process, via inositol 1,3,4-trisphosphate http://purl.obolibrary.org/obo/GO_0033546 GO:0008589 biolink:BiologicalProcess regulation of smoothened signaling pathway Any process that modulates the frequency, rate or extent of smoothened signaling. go.json regulation of hedgehog signaling pathway|regulation of hh signaling pathway|regulation of smoothened activity|regulation of smoothened by patched|regulation of smoothened receptor activity by patched|regulation of smoothened signalling pathway http://purl.obolibrary.org/obo/GO_0008589 GO:0008588 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008588 GO:0008587 biolink:BiologicalProcess imaginal disc-derived wing margin morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade. go.json wing margin morphogenesis http://purl.obolibrary.org/obo/GO_0008587 GO:0008586 biolink:BiologicalProcess imaginal disc-derived wing vein morphogenesis The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized. go.json wing vein morphogenesis http://purl.obolibrary.org/obo/GO_0008586 GO:0008585 biolink:BiologicalProcess female gonad development The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. go.json ovarian development|ovary development http://purl.obolibrary.org/obo/GO_0008585 GO:0008584 biolink:BiologicalProcess male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. go.json testicular development|testis development http://purl.obolibrary.org/obo/GO_0008584 GO:0008583 biolink:BiologicalProcess mystery cell differentiation The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0008583 GO:0008582 biolink:BiologicalProcess regulation of synaptic assembly at neuromuscular junction Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. go.json regulation of synaptic growth at neuromuscular junction http://purl.obolibrary.org/obo/GO_0008582 GO:0008592 biolink:BiologicalProcess regulation of Toll signaling pathway Any process that modulates the frequency, rate or extent of the Tl signaling pathway. go.json regulation of Tl signaling pathway|regulation of Tl signalling pathway|regulation of Toll signalling pathway http://purl.obolibrary.org/obo/GO_0008592 GO:0008591 biolink:BiologicalProcess regulation of Wnt signaling pathway, calcium modulating pathway Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). go.json regulation of Wnt receptor signaling pathway, calcium modulating pathway|regulation of Wnt-activated signaling pathway, calcium modulating pathway|regulation of frizzled-2 signaling pathway|regulation of frizzled-2 signalling pathway http://purl.obolibrary.org/obo/GO_0008591 GO:0008590 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008590 GO:0033545 biolink:BiologicalProcess myo-inositol hexakisphosphate biosynthetic process, lipid-dependent The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C. MetaCyc:PWY-6555 go.json myo-inositol hexakisphosphate anabolism, lipid-dependent|myo-inositol hexakisphosphate biosynthesis, lipid-dependent|myo-inositol hexakisphosphate formation, lipid-dependent|myo-inositol hexakisphosphate synthesis, lipid-dependent|phytate biosynthesis, lipid-dependent|phytate biosynthetic process, lipid-dependent http://purl.obolibrary.org/obo/GO_0033545 GO:0033544 biolink:BiologicalProcess fatty acid beta-oxidation, unsaturated, even number, epimerase pathway A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). go.json http://purl.obolibrary.org/obo/GO_0033544 GO:0033543 biolink:BiologicalProcess fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). go.json http://purl.obolibrary.org/obo/GO_0033543 GO:0033542 biolink:BiologicalProcess fatty acid beta-oxidation, unsaturated, even number A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). MetaCyc:PWY-5138 go.json http://purl.obolibrary.org/obo/GO_0033542 GO:0033541 biolink:BiologicalProcess fatty acid beta-oxidation, unsaturated, odd number A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). MetaCyc:PWY-5137 go.json http://purl.obolibrary.org/obo/GO_0033541 GO:0033540 biolink:BiologicalProcess fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). MetaCyc:PWY-5136 go.json http://purl.obolibrary.org/obo/GO_0033540 GO:0033539 biolink:BiologicalProcess fatty acid beta-oxidation using acyl-CoA dehydrogenase A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). MetaCyc:FAO-PWY go.json http://purl.obolibrary.org/obo/GO_0033539 GO:0033538 biolink:BiologicalProcess ajugose biosynthetic process using galactan:galactan galactosyltransferase The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another. MetaCyc:PWY-5343 go.json ajugose anabolism using galactan:galactan galactosyltransferase|ajugose biosynthesis using galactan:galactan galactosyltransferase|ajugose formation using galactan:galactan galactosyltransferase|ajugose synthesis using galactan:galactan galactosyltransferase http://purl.obolibrary.org/obo/GO_0033538 GO:0033537 biolink:BiologicalProcess ajugose biosynthetic process using galactinol:raffinose galactosyltransferase The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide. MetaCyc:PWY-5342 go.json ajugose anabolism using galactinol:raffinose galactosyltransferase|ajugose biosynthesis using galactinol:raffinose galactosyltransferase|ajugose formation using galactinol:raffinose galactosyltransferase|ajugose synthesis using galactinol:raffinose galactosyltransferase http://purl.obolibrary.org/obo/GO_0033537 GO:0033536 biolink:BiologicalProcess ajugose biosynthetic process The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json ajugose anabolism|ajugose biosynthesis|ajugose formation|ajugose synthesis http://purl.obolibrary.org/obo/GO_0033536 GO:0033535 biolink:BiologicalProcess ajugose metabolic process The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json ajugose metabolism http://purl.obolibrary.org/obo/GO_0033535 GO:0008599 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008599 GO:0008598 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008598 GO:0008597 biolink:MolecularActivity calcium-dependent protein serine/threonine phosphatase regulator activity Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. Reactome:R-HSA-139906 go.json calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0008597 GO:0008596 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008596 GO:0008595 biolink:BiologicalProcess anterior/posterior axis specification, embryo The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. go.json anterior/posterior axis determination, embryo http://purl.obolibrary.org/obo/GO_0008595 GO:0008594 biolink:BiologicalProcess photoreceptor cell morphogenesis The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. go.json photoreceptor development http://purl.obolibrary.org/obo/GO_0008594 GO:0008593 biolink:BiologicalProcess regulation of Notch signaling pathway Any process that modulates the frequency, rate or extent of the Notch signaling pathway. go.json regulation of N signaling pathway|regulation of N signalling pathway|regulation of Notch signalling pathway http://purl.obolibrary.org/obo/GO_0008593 GO:0033534 biolink:BiologicalProcess verbascose biosynthetic process The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json verbascose anabolism|verbascose biosynthesis|verbascose formation|verbascose synthesis http://purl.obolibrary.org/obo/GO_0033534 GO:0033533 biolink:BiologicalProcess verbascose metabolic process The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json verbascose metabolism http://purl.obolibrary.org/obo/GO_0033533 GO:0033532 biolink:BiologicalProcess stachyose biosynthetic process The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. MetaCyc:PWY-5337 go.json stachyose anabolism|stachyose biosynthesis|stachyose formation|stachyose synthesis http://purl.obolibrary.org/obo/GO_0033532 GO:0033531 biolink:BiologicalProcess stachyose metabolic process The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json stachyose metabolism http://purl.obolibrary.org/obo/GO_0033531 GO:0033530 biolink:BiologicalProcess raffinose metabolic process The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. go.json raffinose metabolism http://purl.obolibrary.org/obo/GO_0033530 GO:0033493 biolink:BiologicalProcess esculetin biosynthetic process The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin. MetaCyc:PWY-5349 go.json esculetin anabolism|esculetin biosynthesis|esculetin formation|esculetin synthesis http://purl.obolibrary.org/obo/GO_0033493 GO:0033492 biolink:BiologicalProcess esculetin metabolic process The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin. go.json esculetin metabolism http://purl.obolibrary.org/obo/GO_0033492 GO:0033491 biolink:BiologicalProcess coniferin metabolic process The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside. MetaCyc:PWY-116 go.json coniferin metabolism http://purl.obolibrary.org/obo/GO_0033491 GO:0033490 biolink:BiologicalProcess cholesterol biosynthetic process via lathosterol The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol. MetaCyc:PWY66-341 go.json cholesterol anabolism via lathosterol|cholesterol biosynthesis via lathosterol|cholesterol formation via lathosterol|cholesterol synthesis via lathosterol http://purl.obolibrary.org/obo/GO_0033490 GO:0033499 biolink:BiologicalProcess galactose catabolic process via UDP-galactose The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. MetaCyc:PWY-3821 go.json Leloir Pathway|galactose breakdown via UDP-galactose|galactose catabolism via UDP-galactose|galactose degradation via UDP-galactose http://purl.obolibrary.org/obo/GO_0033499 GO:0033498 biolink:BiologicalProcess galactose catabolic process via D-galactonate The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate. MetaCyc:GALDEG-PWY go.json galactose breakdown via D-galactonate|galactose catabolism via D-galactonate|galactose degradation via D-galactonate http://purl.obolibrary.org/obo/GO_0033498 GO:0033497 biolink:BiologicalProcess sinapate biosynthetic process The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. MetaCyc:PWY-5168 go.json sinapate anabolism|sinapate biosynthesis|sinapate formation|sinapate synthesis http://purl.obolibrary.org/obo/GO_0033497 GO:0033496 biolink:BiologicalProcess sinapate metabolic process The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. go.json sinapate metabolism http://purl.obolibrary.org/obo/GO_0033496 GO:0033495 biolink:BiologicalProcess ferulate biosynthetic process The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate. MetaCyc:PWY-5168 go.json ferulate anabolism|ferulate biosynthesis|ferulate formation|ferulate synthesis http://purl.obolibrary.org/obo/GO_0033495 GO:0033494 biolink:BiologicalProcess ferulate metabolic process The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate. go.json ferulate metabolism http://purl.obolibrary.org/obo/GO_0033494 OIO:hasNarrowSynonym biolink:OntologyClass has_narrow_synonym go.json http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym GO:0033649 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033649 GO:0033648 biolink:CellularComponent host intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json host intracellular membrane-enclosed organelle http://purl.obolibrary.org/obo/GO_0033648 GO:0033647 biolink:CellularComponent host intracellular organelle Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033647 GO:0033646 biolink:CellularComponent host intracellular part Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json host cell intracellular part http://purl.obolibrary.org/obo/GO_0033646 gocheck_do_not_annotate GO:0008689 biolink:MolecularActivity 3-demethylubiquinone-9 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9. RHEA:17049 go.json http://purl.obolibrary.org/obo/GO_0008689 GO:0033645 biolink:CellularComponent host cell endomembrane system A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033645 GO:0008688 biolink:MolecularActivity 3-(3-hydroxyphenyl)propionate hydroxylase activity Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. EC:1.14.13.127|KEGG_REACTION:R06786|MetaCyc:MHPHYDROXY-RXN|RHEA:24785 go.json http://purl.obolibrary.org/obo/GO_0008688 GO:0008687 biolink:MolecularActivity 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+. EC:1.13.11.15|KEGG_REACTION:R03303|MetaCyc:1.13.11.15-RXN|RHEA:15633|UM-BBD_reactionID:r0364 go.json 3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)|3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity|HPC dioxygenase activity|homoprotocatechuate 2,3-dioxygenase activity http://purl.obolibrary.org/obo/GO_0008687 GO:0008686 biolink:MolecularActivity 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+. EC:4.1.99.12|KEGG_REACTION:R07281|MetaCyc:DIOHBUTANONEPSYN-RXN|RHEA:18457 go.json http://purl.obolibrary.org/obo/GO_0008686 GO:0008685 biolink:MolecularActivity 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP. EC:4.6.1.12|KEGG_REACTION:R05637|MetaCyc:RXN0-302|RHEA:23864 go.json 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)|2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)|MECDP-synthase activity|MECP synthase activity http://purl.obolibrary.org/obo/GO_0008685 GO:0008684 biolink:MolecularActivity 2-oxopent-4-enoate hydratase activity Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. EC:4.2.1.80|MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN|RHEA:22580|UM-BBD_enzymeID:e0078 go.json 2-keto-4-pentenoate (vinylpyruvate)hydratase activity|2-keto-4-pentenoate hydratase activity|4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)|4-hydroxy-2-oxopentanoate hydro-lyase activity|OEH activity http://purl.obolibrary.org/obo/GO_0008684 GO:0008683 biolink:MolecularActivity 2-oxoglutarate decarboxylase activity Catalysis of the reaction: 2-oxoglutarate + H+ = CO2 + succinate semialdehyde. EC:4.1.1.71|KEGG_REACTION:R00272|MetaCyc:RXN-7774|RHEA:10524 go.json 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)|2-oxoglutarate carboxy-lyase activity|alpha-ketoglutarate decarboxylase activity|alpha-ketoglutaric decarboxylase activity|pre-2-oxoglutarate decarboxylase activity http://purl.obolibrary.org/obo/GO_0008683 GO:0008682 biolink:MolecularActivity 3-demethoxyubiquinol 3-hydroxylase activity Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O. EC:1.14.99.60|MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN|RHEA:50908 go.json 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity|demethoxy-ubiquinone hydroxylase|demethoxyubiquinone monooxygenase http://purl.obolibrary.org/obo/GO_0008682 GO:0008681 biolink:MolecularActivity 2-octaprenyl-6-methoxyphenol hydroxylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O. MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN|RHEA:29407 go.json http://purl.obolibrary.org/obo/GO_0008681 GO:0008691 biolink:MolecularActivity 3-hydroxybutyryl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+. EC:1.1.1.157|MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN|RHEA:16197 go.json (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity|BHBD activity|L(+)-3-hydroxybutyryl-CoA dehydrogenase activity|L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity|beta-hydroxybutyryl coenzyme A dehydrogenase activity|beta-hydroxybutyryl-CoA dehydrogenase activity|dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate) http://purl.obolibrary.org/obo/GO_0008691 GO:0008690 biolink:MolecularActivity 3-deoxy-manno-octulosonate cytidylyltransferase activity Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. EC:2.7.7.38|MetaCyc:CPM-KDOSYNTH-RXN|RHEA:23448 go.json 2-keto-3-deoxyoctonate cytidylyltransferase activity|3-deoxy-D-manno-octulosonate cytidylyltransferase activity|CMP-2-keto-3-deoxyoctulosonic acid synthetase activity|CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity|CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity|CMP-3-deoxy-D-manno-octulosonate synthetase activity|CMP-KDO synthetase activity|CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity|CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity|CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity|cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0008690 GO:0018007 biolink:BiologicalProcess N-terminal peptidyl-glycine N-glucuronylation The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine. RESID:AA0058 go.json http://purl.obolibrary.org/obo/GO_0018007 GO:0018006 biolink:BiologicalProcess N-terminal protein amino acid glucuronylation The glucuronylation of the N-terminal amino acid of proteins. go.json http://purl.obolibrary.org/obo/GO_0018006 GO:0018009 biolink:BiologicalProcess N-terminal peptidyl-L-cysteine N-palmitoylation The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine. RESID:AA0060 go.json http://purl.obolibrary.org/obo/GO_0018009 gocheck_do_not_annotate GO:0018008 biolink:BiologicalProcess N-terminal peptidyl-glycine N-myristoylation The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. RESID:AA0059 go.json N-terminal peptidyl-glycine N-myristylation http://purl.obolibrary.org/obo/GO_0018008 gocheck_do_not_annotate GO:0018003 biolink:BiologicalProcess peptidyl-lysine N6-acetylation The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine. RESID:AA0055 go.json http://purl.obolibrary.org/obo/GO_0018003 gocheck_do_not_annotate GO:0033644 biolink:CellularComponent host cell membrane Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033644 GO:0018002 biolink:BiologicalProcess N-terminal peptidyl-glutamic acid acetylation The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid. RESID:AA0044 go.json http://purl.obolibrary.org/obo/GO_0018002 gocheck_do_not_annotate GO:0033643 biolink:CellularComponent host cell part Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033643 gocheck_do_not_annotate GO:0018005 biolink:BiologicalProcess N-terminal peptidyl-glycine N-formylation The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine. RESID:AA0057 go.json http://purl.obolibrary.org/obo/GO_0018005 gocheck_do_not_annotate GO:0033642 biolink:BiologicalProcess obsolete modulation by symbiont of host response to gravitational stimulus OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response to gravitational stimulus True http://purl.obolibrary.org/obo/GO_0033642 GO:0018004 biolink:BiologicalProcess N-terminal protein formylation The formylation of the N-terminal amino acid of proteins. go.json http://purl.obolibrary.org/obo/GO_0018004 gocheck_do_not_annotate GO:0033641 biolink:BiologicalProcess obsolete modulation by symbiont of host response to pH OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0033641 GO:0033640 biolink:BiologicalProcess obsolete modulation by symbiont of host response to osmotic stress OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0033640 GO:0018001 biolink:BiologicalProcess N-terminal peptidyl-valine acetylation The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine. RESID:AA0054 go.json http://purl.obolibrary.org/obo/GO_0018001 gocheck_do_not_annotate GO:0018000 biolink:BiologicalProcess N-terminal peptidyl-tyrosine acetylation The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine. RESID:AA0053 go.json http://purl.obolibrary.org/obo/GO_0018000 gocheck_do_not_annotate GO:0033639 biolink:BiologicalProcess obsolete modulation by symbiont of host response to water OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0033639 GO:0033638 biolink:BiologicalProcess modulation by symbiont of host heat acclimation Any process in which an organism modulates the host's tolerance to high temperatures, above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host response to heat|response to heat shock http://purl.obolibrary.org/obo/GO_0033638 GO:0033637 biolink:BiologicalProcess obsolete modulation by symbiont of host response to cold OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json freezing tolerance True http://purl.obolibrary.org/obo/GO_0033637 GO:0033636 biolink:BiologicalProcess obsolete modulation by symbiont of host response to temperature stimulus OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host response to thermal stimulus True http://purl.obolibrary.org/obo/GO_0033636 GO:0033635 biolink:BiologicalProcess modulation by symbiont of host response to abiotic stimulus Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033635 GO:0033634 biolink:BiologicalProcess positive regulation of cell-cell adhesion mediated by integrin Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin. go.json positive regulation of cell-cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033634 GO:0008699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008699 GO:0008698 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008698 GO:0008697 biolink:MolecularActivity 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. EC:5.3.1.17|KEGG_REACTION:R04383|MetaCyc:5.3.1.17-RXN|RHEA:23896 go.json 4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity|4-deoxy-L-threo-5-hexulose uronate isomerase activity|5-keto-4-deoxyuronate isomerase activity http://purl.obolibrary.org/obo/GO_0008697 GO:0008696 biolink:MolecularActivity 4-amino-4-deoxychorismate lyase activity Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate. EC:4.1.3.38|KEGG_REACTION:R05553|MetaCyc:ADCLY-RXN|RHEA:16201 go.json 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)|4-amino-4-deoxychorismate pyruvate-lyase activity|ADC lyase activity|aminodeoxychorismate lyase activity|enzyme X activity|p-aminobenzoate synthetase|para-aminobenzoic acid (PABA) synthase|para-aminobenzoic acid synthase http://purl.obolibrary.org/obo/GO_0008696 GO:0008695 biolink:MolecularActivity 3-phenylpropionate dioxygenase activity Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol. EC:1.14.12.19|MetaCyc:HCAMULTI-RXN|RHEA:20357|UM-BBD_enzymeID:e0307 go.json 3-phenylpropanoate dioxygenase activity|3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity|Hca dioxygenase activity|HcaA1A2CD http://purl.obolibrary.org/obo/GO_0008695 GO:0008694 biolink:MolecularActivity 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2. EC:4.1.1.98|MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN|RHEA:27778 go.json 3-octaprenyl-4-hydroxybenzoate decarboxylase activity|3-polyprenyl 4-hydroxybenzoate decarboxylase activity|3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity|PPHB decarboxylase activity|UbiD|UbiX|polyprenyl p-hydroxybenzoate decarboxylase activity http://purl.obolibrary.org/obo/GO_0008694 GO:0008693 biolink:MolecularActivity (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. RHEA:41860 go.json (3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity|3-hydroxydecanoyl-ACP dehydratase activity|3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity|3-hydroxydecanoyl-acyl carrier protein dehydrase activity|3-hydroxydecanoyl-acyl carrier protein dehydratase activity|3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity|beta-hydroxyacyl-ACP dehydrase activity|beta-hydroxyacyl-acyl carrier protein dehydratase activity|beta-hydroxydecanoate dehydrase activity|beta-hydroxydecanoyl thioester dehydrase activity http://purl.obolibrary.org/obo/GO_0008693 GO:0008692 biolink:MolecularActivity 3-hydroxybutyryl-CoA epimerase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. EC:5.1.2.3|MetaCyc:OHBUTYRYL-COA-EPIM-RXN|RHEA:21760 go.json 3-hydroxyacyl-CoA epimerase activity|3-hydroxybutanoyl-CoA 3-epimerase activity|3-hydroxybutyryl coenzyme A epimerase activity http://purl.obolibrary.org/obo/GO_0008692 GO:0018018 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018018 GO:0018017 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018017 GO:0018019 biolink:BiologicalProcess N-terminal peptidyl-glutamine methylation The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative. RESID:AA0071 go.json http://purl.obolibrary.org/obo/GO_0018019 gocheck_do_not_annotate GO:0018014 biolink:BiologicalProcess N-terminal peptidyl-methionine methylation The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine. RESID:AA0064 go.json http://purl.obolibrary.org/obo/GO_0018014 gocheck_do_not_annotate GO:0033633 biolink:BiologicalProcess negative regulation of cell-cell adhesion mediated by integrin Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin. go.json negative regulation of cell-cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033633 GO:0018013 biolink:BiologicalProcess N-terminal peptidyl-glycine methylation The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine. RESID:AA0063 go.json http://purl.obolibrary.org/obo/GO_0018013 gocheck_do_not_annotate GO:0033632 biolink:BiologicalProcess regulation of cell-cell adhesion mediated by integrin Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. go.json regulation of cell-cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033632 GO:0033631 biolink:BiologicalProcess cell-cell adhesion mediated by integrin The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. go.json cell-cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033631 GO:0018016 biolink:BiologicalProcess N-terminal peptidyl-proline dimethylation The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline. RESID:AA0066 go.json http://purl.obolibrary.org/obo/GO_0018016 gocheck_do_not_annotate GO:0033630 biolink:BiologicalProcess positive regulation of cell adhesion mediated by integrin Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. go.json positive regulation of cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033630 GO:0018015 biolink:BiologicalProcess N-terminal peptidyl-phenylalanine methylation The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine. RESID:AA0065 go.json http://purl.obolibrary.org/obo/GO_0018015 gocheck_do_not_annotate GO:0018010 biolink:MolecularActivity obsolete glycoprotein N-palmitoyltransferase activity OBSOLETE. Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein. MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN go.json mucus glycoprotein fatty acyltransferase|palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity True http://purl.obolibrary.org/obo/GO_0018010 GO:0018012 biolink:BiologicalProcess N-terminal peptidyl-alanine trimethylation The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine. RESID:AA0062 go.json http://purl.obolibrary.org/obo/GO_0018012 gocheck_do_not_annotate GO:0018011 biolink:BiologicalProcess N-terminal peptidyl-alanine methylation The methylation of the N-terminal alanine of proteins. RESID:AA0061|RESID:AA0062 go.json http://purl.obolibrary.org/obo/GO_0018011 gocheck_do_not_annotate GO:0033629 biolink:BiologicalProcess negative regulation of cell adhesion mediated by integrin Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. go.json negative regulation of cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033629 GO:0033628 biolink:BiologicalProcess regulation of cell adhesion mediated by integrin Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. go.json regulation of cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033628 GO:0033627 biolink:BiologicalProcess cell adhesion mediated by integrin The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. go.json cell adhesion mediated by integrin complex http://purl.obolibrary.org/obo/GO_0033627 GO:0033626 biolink:BiologicalProcess positive regulation of integrin activation by cell surface receptor linked signal transduction Any process that activates or increases the frequency, rate, or extent of integrin activation by cell surface receptor linked signal transduction. This can occur by increased affinity of an integrin for its extracellular ligands. go.json cell surface receptor linked signal transduction leading to integrin activation|cell surface receptor linked signal transduction leading to integrin complex activation http://purl.obolibrary.org/obo/GO_0033626 GO:0033625 biolink:BiologicalProcess positive regulation of integrin activation Any process that activates or increases the frequency, rate, or extent of integrin activation. go.json positive regulation of integrin complex activation http://purl.obolibrary.org/obo/GO_0033625 GO:0008669 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008669 GO:0008668 biolink:MolecularActivity (2,3-dihydroxybenzoyl)adenylate synthase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate. EC:2.7.7.58|KEGG_REACTION:R01504|MetaCyc:DHBAMPLIG-RXN|RHEA:20229 go.json 2,3-dihydroxybenzoate-AMP ligase activity|ATP:2,3-dihydroxybenzoate adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0008668 GO:0033624 biolink:BiologicalProcess negative regulation of integrin activation Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation. go.json negative regulation of integrin complex activation http://purl.obolibrary.org/obo/GO_0033624 GO:0008667 biolink:MolecularActivity 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH. EC:1.3.1.28|KEGG_REACTION:R01505|MetaCyc:DHBDEHYD-RXN|RHEA:23824 go.json 2,3-DHB dehydrogenase activity|2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008667 GO:0033623 biolink:BiologicalProcess regulation of integrin activation Any process that modulates the frequency, rate, or extent of integrin activation. go.json regulation of integrin complex activation http://purl.obolibrary.org/obo/GO_0033623 GO:0008666 biolink:MolecularActivity 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA. EC:2.3.1.117|KEGG_REACTION:R04365|MetaCyc:TETHYDPICSUCC-RXN|RHEA:17325 go.json THDP N-succinyltransferase activity|succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity|succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity|succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity|tetrahydrodipicolinate N-succinyltransferase activity|tetrahydrodipicolinate succinylase activity|tetrahydrodipicolinate succinyltransferase activity|tetrahydropicolinate succinylase activity http://purl.obolibrary.org/obo/GO_0008666 RO:0003001 biolink:OntologyClass produced by RO:0003001 go.json http://purl.obolibrary.org/obo/RO_0003001 GO:0008665 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008665 GO:0008664 biolink:MolecularActivity 2'-5'-RNA ligase activity Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. go.json 2'-5' RNA ligase activity http://purl.obolibrary.org/obo/GO_0008664 GO:0008663 biolink:MolecularActivity 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. EC:3.1.4.16|MetaCyc:CYCPHOSDIESTER-RXN|RHEA:19621 go.json 2',3 '-cyclic AMP phosphodiesterase activity|2',3'-cyclic AMP 2'-phosphohydrolase activity|2',3'-cyclic nucleoside monophosphate phosphodiesterase|2',3'-cyclic nucleotidase activity|2',3'-cyclic nucleotide phosphohydrolase|2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity|2':3'-cyclic phosphodiesterase activity|cyclic 2',3'-nucleotide 2'-phosphodiesterase activity|cyclic 2',3'-nucleotide phosphodiesterase|cyclic phosphodiesterase:3'-nucleotidase activity|nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity|ribonucleoside 2',3'-cyclic phosphate diesterase activity http://purl.obolibrary.org/obo/GO_0008663 GO:0008662 biolink:MolecularActivity 1-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate. EC:2.7.1.56|MetaCyc:1PFRUCTPHOSN-RXN|RHEA:14213 go.json 1-phosphofructokinase (phosphorylating)|ATP:D-fructose-phosphate 6-phosphotransferase activity|D-fructose-1-phosphate kinase activity|fructose 1-phosphate kinase activity|fructose-1-phosphate kinase activity|phosphofructokinase 1 http://purl.obolibrary.org/obo/GO_0008662 GO:0008661 biolink:MolecularActivity 1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2. EC:2.2.1.7|KEGG_REACTION:R05636|MetaCyc:DXS-RXN|RHEA:12605 go.json 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity|1-deoxyxylulose-5-phosphate synthase activity|DOXP synthase activity|DXP-synthase activity|pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating) http://purl.obolibrary.org/obo/GO_0008661 RO:0003000 biolink:OntologyClass produces RO:0003000 go.json http://purl.obolibrary.org/obo/RO_0003000 GO:0008660 biolink:MolecularActivity 1-aminocyclopropane-1-carboxylate deaminase activity Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanate + NH4. EC:3.5.99.7|KEGG_REACTION:R00997|MetaCyc:4.1.99.4-RXN|RHEA:16933|UM-BBD_reactionID:r0357 go.json 1-aminocyclopropane carboxylic acid deaminase activity|1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)|1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity|ACC deaminase activity http://purl.obolibrary.org/obo/GO_0008660 GO:0033622 biolink:BiologicalProcess integrin activation The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. go.json integrin complex activation|integrin complex assembly http://purl.obolibrary.org/obo/GO_0033622 GO:0033621 biolink:BiologicalProcess nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. go.json degradation of meiosis-specific transcripts|mRNA breakdown, meiosis-specific transcripts|mRNA catabolism, meiosis-specific transcripts|mRNA degradation, meiosis-specific transcripts|nuclear mRNA catabolic process, meiosis-specific transcripts http://purl.obolibrary.org/obo/GO_0033621 GO:0033620 biolink:CellularComponent Mei2 nuclear dot complex A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I. go.json Mei2 dot|Mei2 nuclear dot|nuclear body http://purl.obolibrary.org/obo/GO_0033620 GO:0033619 biolink:BiologicalProcess membrane protein proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. go.json http://purl.obolibrary.org/obo/GO_0033619 GO:0033618 biolink:BiologicalProcess plasma membrane respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane. go.json plasma membrane cytochrome c oxidase biogenesis|plasma membrane cytochrome c oxidase complex assembly http://purl.obolibrary.org/obo/GO_0033618 GO:0033617 biolink:BiologicalProcess mitochondrial cytochrome c oxidase assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane. go.json mitochondrial cytochrome c oxidase biogenesis|mitochondrial cytochrome c oxidase complex assembly|mitochondrial respiratory chain complex IV assembly http://purl.obolibrary.org/obo/GO_0033617 GO:0033616 biolink:BiologicalProcess plasma membrane proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0033616 GO:0033615 biolink:BiologicalProcess mitochondrial proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. go.json http://purl.obolibrary.org/obo/GO_0033615 GO:0033614 biolink:BiologicalProcess chloroplast proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane. go.json http://purl.obolibrary.org/obo/GO_0033614 GO:0008679 biolink:MolecularActivity 2-hydroxy-3-oxopropionate reductase activity Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. EC:1.1.1.60|MetaCyc:TSA-REDUCT-RXN go.json (R)-glycerate:NAD(P)+ oxidoreductase activity|tartronate semialdehyde reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0008679 GO:0033613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033613 GO:0008678 biolink:MolecularActivity 2-deoxy-D-gluconate 3-dehydrogenase activity Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+. EC:1.1.1.125|MetaCyc:KDUD-RXN|RHEA:12160 go.json 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity|2-deoxygluconate dehydrogenase activity|2-keto-3-deoxygluconate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008678 GO:0033612 biolink:MolecularActivity receptor serine/threonine kinase binding Binding to a receptor that possesses protein serine/threonine kinase activity. go.json transmembrane receptor protein serine/threonine kinase ligand binding http://purl.obolibrary.org/obo/GO_0033612 GO:0043003 biolink:BiologicalProcess obsolete positive regulation of Golgi to plasma membrane CFTR protein transport OBSOLETE. Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. go.json activation of Golgi to plasma membrane CFTR protein transport|stimulation of Golgi to plasma membrane CFTR protein transport|up regulation of Golgi to plasma membrane CFTR protein transport|up-regulation of Golgi to plasma membrane CFTR protein transport|upregulation of Golgi to plasma membrane CFTR protein transport True http://purl.obolibrary.org/obo/GO_0043003 GO:0008677 biolink:MolecularActivity 2-dehydropantoate 2-reductase activity Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. EC:1.1.1.169|KEGG_REACTION:R02472|MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN|RHEA:16233 go.json (R)-pantoate:NADP+ 2-oxidoreductase activity|2-ketopantoate reductase activity|2-ketopantoic acid reductase activity|2-oxopantoate reductase activity|KPA reductase activity|ketopantoate reductase activity|ketopantoic acid reductase activity http://purl.obolibrary.org/obo/GO_0008677 GO:0043002 biolink:BiologicalProcess obsolete negative regulation of Golgi to plasma membrane CFTR protein transport OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. go.json down regulation of Golgi to plasma membrane CFTR protein transport|down-regulation of Golgi to plasma membrane CFTR protein transport|downregulation of Golgi to plasma membrane CFTR protein transport|inhibition of Golgi to plasma membrane CFTR protein transport True http://purl.obolibrary.org/obo/GO_0043002 GO:0008676 biolink:MolecularActivity 3-deoxy-8-phosphooctulonate synthase activity Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate. EC:2.5.1.55|KEGG_REACTION:R03254|MetaCyc:KDO-8PSYNTH-RXN|RHEA:14053 go.json 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity|2-dehydro-3-deoxy-phosphooctonate aldolase activity|2-dehydro-3-deoxyphosphooctonate aldolase activity|2-keto-3-deoxy-8-phosphooctonic synthetase activity|3-deoxy-D-manno-octulosonate-8-phosphate synthase activity|3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity|3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity|3-deoxyoctulosonic 8-phosphate synthetase activity|KDO-8-P synthase activity|KDO-8-phosphate synthetase activity|KDOP synthase activity|phospho-2-keto-3-deoxyoctonate aldolase activity|phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) http://purl.obolibrary.org/obo/GO_0008676 GO:0043005 biolink:CellularComponent neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. NIF_Subcellular:sao867568886 go.json nerve fiber|neurite|neuron process|neuron protrusion|neuronal cell projection http://purl.obolibrary.org/obo/GO_0043005 goslim_pir GO:0008675 biolink:MolecularActivity 2-dehydro-3-deoxy-phosphogluconate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. EC:4.1.2.14|MetaCyc:KDPGALDOL-RXN|RHEA:17089 go.json 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)|2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity|2-keto-3-deoxy-6-phosphogluconate aldolase activity|2-keto-3-deoxy-6-phosphogluconic aldolase activity|2-keto-3-deoxygluconate-6-P-aldolase activity|2-keto-3-deoxygluconate-6-phosphate aldolase activity|2-oxo-3-deoxy-6-phosphogluconate aldolase activity|6-phospho-2-keto-3-deoxygluconate aldolase activity|KDPG aldolase activity|KDPG-aldolase activity|ODPG aldolase activity|phospho-2-dehydro-3-deoxygluconate aldolase activity|phospho-2-keto-3-deoxygluconate aldolase activity|phospho-2-keto-3-deoxygluconic aldolase activity http://purl.obolibrary.org/obo/GO_0008675 GO:0008674 biolink:MolecularActivity 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate. EC:4.1.2.21|KEGG_REACTION:R01064|MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN|RHEA:24464 go.json (KDPGal)aldolase activity|2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)|2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity|2-dehydro-3-deoxyphosphogalactonate aldolase activity|2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity|2-keto-3-deoxy-6-phosphogalactonic aldolase activity|2-oxo-3-deoxygalactonate 6-phosphate aldolase activity|6-phospho-2-dehydro-3-deoxygalactonate aldolase activity|6-phospho-2-keto-3-deoxygalactonate aldolase activity|phospho-2-keto-3-deoxygalactonate aldolase activity|phospho-2-keto-3-deoxygalactonic aldolase activity http://purl.obolibrary.org/obo/GO_0008674 GO:0043004 biolink:BiologicalProcess obsolete cytoplasmic sequestering of CFTR protein OBSOLETE. The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane. go.json cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein|cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein|cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)|cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein|maintenance of CFTR protein location in cytoplasm|retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm|sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm|sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm|storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm True http://purl.obolibrary.org/obo/GO_0043004 GO:0008673 biolink:MolecularActivity 2-dehydro-3-deoxygluconokinase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. EC:2.7.1.45|KEGG_REACTION:R01541|MetaCyc:DEOXYGLUCONOKIN-RXN|RHEA:14797 go.json 2-keto-3-deoxy-D-gluconic acid kinase activity|2-keto-3-deoxygluconate kinase activity|2-keto-3-deoxygluconokinase (phosphorylating)|2-keto-3-deoxygluconokinase activity|3-deoxy-2-oxo-D-gluconate kinase activity|ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity|KDG kinase activity|ketodeoxygluconokinase activity http://purl.obolibrary.org/obo/GO_0008673 GO:0008672 biolink:MolecularActivity 2-dehydro-3-deoxyglucarate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. EC:4.1.2.20|MetaCyc:KDGALDOL-RXN|RHEA:10268 go.json 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)|2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity|2-keto-3-deoxyglucarate aldolase activity|alpha-keto-beta-deoxy-D-glucarate aldolase activity http://purl.obolibrary.org/obo/GO_0008672 GO:0008671 biolink:MolecularActivity 2-dehydro-3-deoxygalactonokinase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. EC:2.7.1.58|KEGG_REACTION:R03387|MetaCyc:DEHYDDEOXGALACTKIN-RXN|RHEA:16525 go.json 2-keto-3-deoxy-galactonokinase activity|2-keto-3-deoxygalactonate kinase (phosphorylating)|2-keto-3-deoxygalactonokinase activity|2-oxo-3-deoxygalactonate kinase activity|ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0008671 GO:0043001 biolink:BiologicalProcess Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0043001 GO:0043000 biolink:BiologicalProcess obsolete Golgi to plasma membrane CFTR protein transport OBSOLETE. The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. go.json Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport True http://purl.obolibrary.org/obo/GO_0043000 GO:0008670 biolink:MolecularActivity 2,4-dienoyl-CoA reductase (NADPH) activity Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+. EC:1.3.1.34|MetaCyc:DIENOYLCOAREDUCT-RXN|RHEA:12136 go.json 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|4-enoyl-CoA reductase (NADPH) activity|4-enoyl-CoA reductase (NADPH2)|4-enoyl-CoA reductase activity|trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008670 GO:0008680 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008680 GO:0043007 biolink:BiologicalProcess maintenance of rDNA Any process involved in sustaining the fidelity and copy number of rDNA repeats. go.json rDNA maintenance|ribosomal DNA maintenance http://purl.obolibrary.org/obo/GO_0043007 GO:0043006 biolink:BiologicalProcess obsolete activation of phospholipase A2 activity by calcium-mediated signaling OBSOLETE. The series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal. go.json activation of phospholipase A2 activity by calcium-mediated signalling|calcium-dependent activation of phospholipase A2|calcium-dependent phospholipase A2 activation True http://purl.obolibrary.org/obo/GO_0043006 GO:0043009 biolink:BiologicalProcess chordate embryonic development The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. go.json http://purl.obolibrary.org/obo/GO_0043009 GO:0043008 biolink:MolecularActivity ATP-dependent protein binding Binding to a protein or protein complex using energy from ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0043008 goslim_chembl GO:0033611 biolink:BiologicalProcess oxalate catabolic process The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate. go.json ethanedioate catabolic process|ethanedioic acid catabolic process|oxalate breakdown|oxalate catabolism|oxalate degradation|oxalic acid catabolic process http://purl.obolibrary.org/obo/GO_0033611 GO:0033610 biolink:BiologicalProcess oxalate biosynthetic process The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate. go.json ethanedioate biosynthetic process|ethanedioic acid biosynthetic process|oxalate anabolism|oxalate biosynthesis|oxalate formation|oxalate synthesis|oxalic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0033610 GO:0033608 biolink:MolecularActivity formyl-CoA transferase activity Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA. EC:2.8.3.16|KEGG_REACTION:R07290|MetaCyc:RXN0-1382|RHEA:16545 go.json formyl-CoA oxalate CoA-transferase activity|formyl-CoA:oxalate CoA-transferase activity|formyl-coenzyme A transferase activity http://purl.obolibrary.org/obo/GO_0033608 GO:0033607 biolink:CellularComponent SOD1-Bcl-2 complex A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway. go.json http://purl.obolibrary.org/obo/GO_0033607 GO:0033606 biolink:BiologicalProcess chemokine receptor transport within lipid bilayer The directed movement of a chemokine receptor within a lipid bilayer. go.json chemokine receptor translocation within membrane http://purl.obolibrary.org/obo/GO_0033606 GO:0008649 biolink:MolecularActivity rRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. go.json http://purl.obolibrary.org/obo/GO_0008649 GO:0033605 biolink:BiologicalProcess positive regulation of catecholamine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. go.json activation of catecholamine secretion|stimulation of catecholamine secretion|up regulation of catecholamine secretion|up-regulation of catecholamine secretion|upregulation of catecholamine secretion http://purl.obolibrary.org/obo/GO_0033605 GO:0033604 biolink:BiologicalProcess negative regulation of catecholamine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. go.json down regulation of catecholamine secretion|down-regulation of catecholamine secretion|downregulation of catecholamine secretion|inhibition of catecholamine secretion http://purl.obolibrary.org/obo/GO_0033604 GO:0008648 biolink:MolecularActivity obsolete tachykinin OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation. go.json tachykinin True http://purl.obolibrary.org/obo/GO_0008648 GO:0033603 biolink:BiologicalProcess positive regulation of dopamine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine. go.json activation of dopamine secretion|stimulation of dopamine secretion|up regulation of dopamine secretion|up-regulation of dopamine secretion|upregulation of dopamine secretion http://purl.obolibrary.org/obo/GO_0033603 GO:0008647 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008647 GO:0033602 biolink:BiologicalProcess negative regulation of dopamine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine. go.json down regulation of dopamine secretion|down-regulation of dopamine secretion|downregulation of dopamine secretion|inhibition of dopamine secretion http://purl.obolibrary.org/obo/GO_0033602 GO:0008646 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008646 GO:0008645 biolink:BiologicalProcess hexose transmembrane transport The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. go.json hexose membrane transport|hexose transport|high-affinity hexose transport|low-affinity hexose transport http://purl.obolibrary.org/obo/GO_0008645 GO:0033601 biolink:BiologicalProcess positive regulation of mammary gland epithelial cell proliferation Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. go.json activation of mammary gland epithelial cell proliferation|stimulation of mammary gland epithelial cell proliferation|up regulation of mammary gland epithelial cell proliferation|up-regulation of mammary gland epithelial cell proliferation|upregulation of mammary gland epithelial cell proliferation http://purl.obolibrary.org/obo/GO_0033601 GO:0043014 biolink:MolecularActivity alpha-tubulin binding Binding to the microtubule constituent protein alpha-tubulin. go.json alpha tubulin binding http://purl.obolibrary.org/obo/GO_0043014 GO:0008644 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008644 GO:0008643 biolink:BiologicalProcess carbohydrate transport The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. go.json sugar transport http://purl.obolibrary.org/obo/GO_0008643 goslim_pir|goslim_yeast GO:0043013 biolink:BiologicalProcess negative regulation of fusion of sperm to egg plasma membrane Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane. go.json down regulation of fusion of sperm to egg plasma membrane|down-regulation of fusion of sperm to egg plasma membrane|downregulation of fusion of sperm to egg plasma membrane|inhibition of fusion of sperm to egg plasma membrane|inhibition of sperm-oocyte fusion|negative regulation of sperm-oocyte fusion http://purl.obolibrary.org/obo/GO_0043013 GO:0008642 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008642 GO:0043016 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043016 GO:0008641 biolink:MolecularActivity ubiquitin-like modifier activating enzyme activity Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. go.json small protein activating enzyme activity http://purl.obolibrary.org/obo/GO_0008641 goslim_pir GO:0043015 biolink:MolecularActivity gamma-tubulin binding Binding to the microtubule constituent protein gamma-tubulin. go.json gamma tubulin binding http://purl.obolibrary.org/obo/GO_0043015 GO:0043010 biolink:BiologicalProcess camera-type eye development The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. go.json http://purl.obolibrary.org/obo/GO_0043010 GO:0008640 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008640 GO:0043012 biolink:BiologicalProcess regulation of fusion of sperm to egg plasma membrane Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane. go.json regulation of sperm-oocyte fusion http://purl.obolibrary.org/obo/GO_0043012 GO:0033609 biolink:BiologicalProcess oxalate metabolic process The chemical reactions and pathways involving oxalate, the organic acid ethanedioate. go.json ethanedioate metabolic process|ethanedioic acid metabolic process|oxalate metabolism|oxalic acid metabolic process http://purl.obolibrary.org/obo/GO_0033609 GO:0043011 biolink:BiologicalProcess myeloid dendritic cell differentiation The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. Wikipedia:Dendritic_cell go.json http://purl.obolibrary.org/obo/GO_0043011 GO:0043018 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043018 GO:0043017 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043017 GO:0043019 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043019 GO:0033600 biolink:BiologicalProcess negative regulation of mammary gland epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation. go.json down regulation of mammary gland epithelial cell proliferation|down-regulation of mammary gland epithelial cell proliferation|downregulation of mammary gland epithelial cell proliferation|inhibition of mammary gland epithelial cell proliferation http://purl.obolibrary.org/obo/GO_0033600 GO:0008659 biolink:MolecularActivity (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. EC:4.2.1.59|RHEA:41892 go.json (3R)-hydroxymyristoyl-ACP dehydratase activity|(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity http://purl.obolibrary.org/obo/GO_0008659 GO:0008658 biolink:MolecularActivity penicillin binding Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json http://purl.obolibrary.org/obo/GO_0008658 goslim_metagenomics GO:0008657 biolink:MolecularActivity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. go.json DNA gyrase inhibitor activity http://purl.obolibrary.org/obo/GO_0008657 GO:0008656 biolink:MolecularActivity cysteine-type endopeptidase activator activity involved in apoptotic process Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. Reactome:R-HSA-205117|Reactome:R-HSA-449073 go.json caspase activator activity http://purl.obolibrary.org/obo/GO_0008656 GO:0043025 biolink:CellularComponent neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. NIF_Subcellular:sao1044911821|Wikipedia:Soma_(biology) go.json neuron cell body|neuronal cell soma http://purl.obolibrary.org/obo/GO_0043025 goslim_pir GO:0008655 biolink:BiologicalProcess pyrimidine-containing compound salvage Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. go.json pyrimidine salvage http://purl.obolibrary.org/obo/GO_0008655 goslim_pir GO:0043024 biolink:MolecularActivity ribosomal small subunit binding Binding to a small ribosomal subunit. go.json http://purl.obolibrary.org/obo/GO_0043024 GO:0008654 biolink:BiologicalProcess phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. MetaCyc:PHOSLIPSYN-PWY|MetaCyc:PHOSLIPSYN2-PWY go.json phospholipid anabolism|phospholipid biosynthesis|phospholipid formation|phospholipid synthesis http://purl.obolibrary.org/obo/GO_0008654 GO:0008653 biolink:BiologicalProcess lipopolysaccharide metabolic process The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. go.json LPS metabolic process|lipopolysaccharide metabolism http://purl.obolibrary.org/obo/GO_0008653 GO:0043027 biolink:MolecularActivity cysteine-type endopeptidase inhibitor activity involved in apoptotic process Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. go.json caspase inhibitor activity http://purl.obolibrary.org/obo/GO_0043027 GO:0008652 biolink:BiologicalProcess amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. Wikipedia:Amino_acid_synthesis go.json amino acid anabolism|amino acid biosynthesis|amino acid formation|amino acid synthesis|cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_0008652 GO:0043026 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043026 GO:0043021 biolink:MolecularActivity ribonucleoprotein complex binding Binding to a complex of RNA and protein. go.json RNP binding|protein-RNA complex binding|ribonucleoprotein binding http://purl.obolibrary.org/obo/GO_0043021 goslim_pir GO:0008651 biolink:MolecularActivity obsolete actin polymerizing activity OBSOLETE. (Was not defined before being made obsolete). go.json actin polymerizing activity True http://purl.obolibrary.org/obo/GO_0008651 GO:0043020 biolink:CellularComponent NADPH oxidase complex A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. go.json flavocytochrome b558|respiratory-burst oxidase http://purl.obolibrary.org/obo/GO_0043020 GO:0008650 biolink:MolecularActivity rRNA (uridine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. Reactome:R-HSA-6793127 go.json http://purl.obolibrary.org/obo/GO_0008650 GO:0043023 biolink:MolecularActivity ribosomal large subunit binding Binding to a large ribosomal subunit. go.json http://purl.obolibrary.org/obo/GO_0043023 GO:0043022 biolink:MolecularActivity ribosome binding Binding to a ribosome. go.json ribosome receptor activity http://purl.obolibrary.org/obo/GO_0043022 GO:0043029 biolink:BiologicalProcess T cell homeostasis The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. go.json T lymphocyte homeostasis|T-cell homeostasis|T-lymphocyte homeostasis http://purl.obolibrary.org/obo/GO_0043029 GO:0043028 biolink:MolecularActivity cysteine-type endopeptidase regulator activity involved in apoptotic process Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. go.json caspase regulator activity http://purl.obolibrary.org/obo/GO_0043028 GO:0008629 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008629 GO:0008628 biolink:BiologicalProcess hormone-mediated apoptotic signaling pathway The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered. go.json apoptotic signaling pathway in response to hormone|induction of apoptosis by hormones http://purl.obolibrary.org/obo/GO_0008628 GO:0043030 biolink:BiologicalProcess regulation of macrophage activation Any process that modulates the frequency or rate of macrophage activation. go.json regulation of macrophage polarization http://purl.obolibrary.org/obo/GO_0043030 GO:0008627 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to osmotic stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered. go.json induction of apoptosis by ionic changes http://purl.obolibrary.org/obo/GO_0008627 GO:0008626 biolink:BiologicalProcess granzyme-mediated apoptotic signaling pathway The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells. go.json apoptotic signaling pathway in response to granzyme|induction of apoptosis by granzyme http://purl.obolibrary.org/obo/GO_0008626 GO:0008625 biolink:BiologicalProcess extrinsic apoptotic signaling pathway via death domain receptors The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. go.json death receptor-mediated apoptosis|induction of apoptosis via death domain receptors|induction of apoptosis via death receptors http://purl.obolibrary.org/obo/GO_0008625 GO:0008624 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008624 GO:0008623 biolink:CellularComponent CHRAC An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair. go.json ISW2 complex|chromatin accessibility complex http://purl.obolibrary.org/obo/GO_0008623 GO:0008622 biolink:CellularComponent epsilon DNA polymerase complex A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. go.json DNA polymerase epsilon complex http://purl.obolibrary.org/obo/GO_0008622 GO:0043036 biolink:CellularComponent starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. go.json starch granule http://purl.obolibrary.org/obo/GO_0043036 GO:0043035 biolink:MolecularActivity chromatin insulator sequence binding Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. go.json http://purl.obolibrary.org/obo/GO_0043035 GO:0008621 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008621 GO:0043038 biolink:BiologicalProcess amino acid activation The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. go.json http://purl.obolibrary.org/obo/GO_0043038 GO:0008620 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008620 GO:0043037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043037 GO:0043032 biolink:BiologicalProcess positive regulation of macrophage activation Any process that stimulates, induces or increases the rate of macrophage activation. go.json activation of macrophage activation|positive regulation of macrophage polarization|stimulation of macrophage activation|up regulation of macrophage activation|up-regulation of macrophage activation|upregulation of macrophage activation http://purl.obolibrary.org/obo/GO_0043032 GO:0043031 biolink:BiologicalProcess negative regulation of macrophage activation Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. go.json down regulation of macrophage activation|down-regulation of macrophage activation|downregulation of macrophage activation|inhibition of macrophage activation|negative regulation of macrophage polarization http://purl.obolibrary.org/obo/GO_0043031 GO:0043034 biolink:CellularComponent costamere Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. Wikipedia:Costamere go.json http://purl.obolibrary.org/obo/GO_0043034 GO:0043033 biolink:CellularComponent isoamylase complex A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. go.json debranching enzyme complex http://purl.obolibrary.org/obo/GO_0043033 goslim_pir GO:0043039 biolink:BiologicalProcess tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. go.json aminoacyl-tRNA biosynthesis|aminoacyl-tRNA biosynthetic process|tRNA charging http://purl.obolibrary.org/obo/GO_0043039 GO:0043041 biolink:BiologicalProcess amino acid activation for nonribosomal peptide biosynthetic process Activation of an amino acid for incorporation into a peptide by a nonribosomal process. go.json nonribosomal amino acid activation http://purl.obolibrary.org/obo/GO_0043041 GO:0008639 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008639 GO:0008638 biolink:MolecularActivity obsolete protein tagging activity OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation. go.json protein tagging activity True http://purl.obolibrary.org/obo/GO_0008638 GO:0043040 biolink:BiologicalProcess tRNA aminoacylation for nonribosomal peptide biosynthetic process The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis. go.json tRNA aminoacylation for nonribosomal peptide anabolism|tRNA aminoacylation for nonribosomal peptide biosynthesis|tRNA aminoacylation for nonribosomal peptide formation|tRNA aminoacylation for nonribosomal peptide synthesis http://purl.obolibrary.org/obo/GO_0043040 GO:0008637 biolink:BiologicalProcess apoptotic mitochondrial changes The morphological and physiological alterations undergone by mitochondria during apoptosis. go.json http://purl.obolibrary.org/obo/GO_0008637 GO:0008636 biolink:BiologicalProcess obsolete activation of caspase activity by protein phosphorylation OBSOLETE. Upregulation of the activity of a caspase, a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group. go.json activation of caspase activity by protein amino acid phosphorylation|activation of caspase activity by protein phosphorylation|caspase activation via phosphorylation True http://purl.obolibrary.org/obo/GO_0008636 GO:0008635 biolink:BiologicalProcess activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c. go.json activation of caspase activity by cytochrome c|caspase activation via cytochrome c http://purl.obolibrary.org/obo/GO_0008635 gocheck_do_not_annotate GO:0008634 biolink:BiologicalProcess obsolete negative regulation of survival gene product expression OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level. go.json down regulation of survival gene product activity|down-regulation of survival gene product activity|downregulation of survival gene product activity|inhibition of survival gene product activity|negative regulation of survival gene product activity|negative regulation of survival gene product expression|negative regulation of survival gene products True http://purl.obolibrary.org/obo/GO_0008634 GO:0043047 biolink:MolecularActivity single-stranded telomeric DNA binding Binding to single-stranded telomere-associated DNA. go.json telomeric ssDNA binding http://purl.obolibrary.org/obo/GO_0043047 GO:0008633 biolink:BiologicalProcess obsolete activation of pro-apoptotic gene products OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form. go.json activation of pro-apoptotic gene products|induction of pro-apoptotic gene products True http://purl.obolibrary.org/obo/GO_0008633 GO:0043046 biolink:BiologicalProcess obsolete DNA methylation involved in gamete generation OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. go.json de novo DNA methylation True http://purl.obolibrary.org/obo/GO_0043046 GO:0008632 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008632 GO:0008631 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to oxidative stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. go.json induction of apoptosis by oxidative stress|oxidative stress-induced intrinsic apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_0008631 GO:0043049 biolink:BiologicalProcess otic placode formation The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. go.json http://purl.obolibrary.org/obo/GO_0043049 GO:0008630 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to DNA damage The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. go.json DNA damage response, signal transduction resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_0008630 GO:0043048 biolink:BiologicalProcess dolichyl monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative. go.json dolichyl monophosphate anabolism|dolichyl monophosphate biosynthesis|dolichyl monophosphate formation|dolichyl monophosphate synthesis http://purl.obolibrary.org/obo/GO_0043048 GO:0043043 biolink:BiologicalProcess peptide biosynthetic process The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. go.json peptide anabolism|peptide biosynthesis|peptide formation|peptide synthesis http://purl.obolibrary.org/obo/GO_0043043 GO:0043042 biolink:BiologicalProcess amino acid adenylylation by nonribosomal peptide synthase Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor. go.json amino acid adenylation by NRPS|amino acid adenylation by nonribosomal peptide synthase http://purl.obolibrary.org/obo/GO_0043042 GO:0043045 biolink:BiologicalProcess post-fertilization epigenetic regulation of gene expression A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation. go.json DNA methylation involved in embryo development|de novo DNA methylation|epigenetic regulation of embryonic gene expression http://purl.obolibrary.org/obo/GO_0043045 GO:0043044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0043044 GO:0018094 biolink:BiologicalProcess protein polyglycylation The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid. RESID:AA0201 go.json http://purl.obolibrary.org/obo/GO_0018094 gocheck_do_not_annotate GO:0018093 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018093 GO:0018096 biolink:BiologicalProcess peptide cross-linking via S-(2-aminovinyl)-D-cysteine The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine. RESID:AA0204 go.json http://purl.obolibrary.org/obo/GO_0018096 gocheck_do_not_annotate GO:0018095 biolink:BiologicalProcess protein polyglutamylation The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. RESID:AA0202 go.json http://purl.obolibrary.org/obo/GO_0018095 gocheck_do_not_annotate GO:0018090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018090 GO:0018092 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018092 GO:0018091 biolink:BiologicalProcess obsolete peptidyl-asparagine racemization OBSOLETE. The racemization of peptidyl-asparagine. go.json True http://purl.obolibrary.org/obo/GO_0018091 GO:0018087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018087 GO:0018086 biolink:BiologicalProcess obsolete alanine racemization OBSOLETE. (Was not defined before being made obsolete). go.json alanine racemization True http://purl.obolibrary.org/obo/GO_0018086 GO:0018089 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018089 GO:0018088 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018088 GO:0018097 biolink:BiologicalProcess obsolete protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine OBSOLETE. The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine. RESID:AA0207 go.json protein amino acid cinnamylation True http://purl.obolibrary.org/obo/GO_0018097 GO:0018072 biolink:BiologicalProcess peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit. RESID:AA0170 go.json peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid|peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid|peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid http://purl.obolibrary.org/obo/GO_0018072 gocheck_do_not_annotate GO:0018071 biolink:MolecularActivity NAD(P)-cysteine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine. go.json http://purl.obolibrary.org/obo/GO_0018071 GO:0018074 biolink:BiologicalProcess obsolete peptidyl-histidine bromination OBSOLETE. The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown. RESID:AA0173 go.json True http://purl.obolibrary.org/obo/GO_0018074 GO:0018073 biolink:BiologicalProcess obsolete protein bromination OBSOLETE. The addition of one or more bromine atoms to an amino acid residue in a protein. go.json protein amino acid bromination True http://purl.obolibrary.org/obo/GO_0018073 GO:0018070 biolink:BiologicalProcess peptidyl-serine phosphopantetheinylation The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine. RESID:AA0150 go.json http://purl.obolibrary.org/obo/GO_0018070 gocheck_do_not_annotate GO:0018069 biolink:BiologicalProcess peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase. RESID:AA0149 go.json http://purl.obolibrary.org/obo/GO_0018069 gocheck_do_not_annotate GO:0018068 biolink:BiologicalProcess peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases. RESID:AA0147 go.json peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine|peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine|peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0018068 gocheck_do_not_annotate GO:0018065 biolink:BiologicalProcess obsolete protein-cofactor linkage OBSOLETE. The covalent attachment of a cofactor to a protein. go.json True http://purl.obolibrary.org/obo/GO_0018065 GO:0018064 biolink:MolecularActivity protein-L-histidine N-tele-methyltransferase activity Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. EC:2.1.1.85|MetaCyc:2.1.1.85-RXN|RHEA:19369 go.json S-adenosyl methionine:protein-histidine N-methyltransferase activity|S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity|actin-specific histidine methyltransferase activity|peptidyl-histidine N-methyltransferase activity|protein (histidine) methyltransferase activity|protein methylase IV activity|protein-histidine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0018064 GO:0018067 biolink:BiologicalProcess peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA). RESID:AA0146 go.json peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine|peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine|peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine http://purl.obolibrary.org/obo/GO_0018067 gocheck_do_not_annotate GO:0018083 biolink:BiologicalProcess peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases. RESID:AA0185 go.json peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine|peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine|peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine http://purl.obolibrary.org/obo/GO_0018083 gocheck_do_not_annotate GO:0018082 biolink:BiologicalProcess peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine. RESID:AA0182 go.json peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine|peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine|peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine http://purl.obolibrary.org/obo/GO_0018082 gocheck_do_not_annotate GO:0018085 biolink:BiologicalProcess peptidyl-L-amino acid racemization The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid. go.json http://purl.obolibrary.org/obo/GO_0018085 gocheck_do_not_annotate GO:0018084 biolink:BiologicalProcess peptidyl-lactic acid biosynthetic process from peptidyl-serine The modification of N-terminal peptidyl-serine to lactic acid. RESID:AA0186 go.json peptidyl-lactic acid anabolism from peptidyl-serine|peptidyl-lactic acid formation from peptidyl-serine|peptidyl-lactic acid synthesis from peptidyl-serine http://purl.obolibrary.org/obo/GO_0018084 gocheck_do_not_annotate GO:0018081 biolink:BiologicalProcess peptide cross-linking via lanthionine or 3-methyl-lanthionine The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process. RESID:AA0110|RESID:AA0111|RESID:AA0112 go.json peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine|peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine http://purl.obolibrary.org/obo/GO_0018081 gocheck_do_not_annotate GO:0018080 biolink:BiologicalProcess obsolete peptidyl-tryptophan bromination OBSOLETE. The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan. RESID:AA0179 go.json True http://purl.obolibrary.org/obo/GO_0018080 GO:0033691 biolink:MolecularActivity sialic acid binding Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. go.json N-acetylneuraminic acid binding http://purl.obolibrary.org/obo/GO_0033691 GO:0033690 biolink:BiologicalProcess positive regulation of osteoblast proliferation Any process that activates or increases the rate or extent of osteoblast proliferation. go.json activation of osteoblast proliferation|stimulation of osteoblast proliferation|up regulation of osteoblast proliferation|up-regulation of osteoblast proliferation|upregulation of osteoblast proliferation http://purl.obolibrary.org/obo/GO_0033690 GO:0033699 biolink:MolecularActivity DNA 5'-adenosine monophosphate hydrolase activity Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. EC:3.6.1.71 go.json AMP-removal activity|DNA 5'-adenylate hydrolase activity|DNA adenylate hydrolysis activity|DNA de-adenylation|DNA deadenylation http://purl.obolibrary.org/obo/GO_0033699 GO:0018079 biolink:BiologicalProcess obsolete protein halogenation OBSOLETE. The addition of a halogen to a protein amino acid. go.json protein amino acid halogenation True http://purl.obolibrary.org/obo/GO_0018079 GO:0033698 biolink:CellularComponent Rpd3L complex A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a two copies of catalytic histone deacetylase subunit (S. pombe Clr6/ S. cerevisiae Rpd3p), an Sds-3 family protein (S. pombe /S. cerevisiae Sds3(p) ), two copies of SIN3 family co-repressor (S. pombe Pst1/ S. cerevisiae Sin3p, a WD repeat protein/ histone chaperone (S. pombe Prw1/ S. cerevisiae Ume1p), and a zf- PHD finger ( S. pombe Png2/ S. cerevisiae Pho23p), plus 4 additional subunits, and associated factors. go.json Clr6 histone deacetylase complex I/I'|Clr6L complex|Rpd3C(L)|Sin3L complex http://purl.obolibrary.org/obo/GO_0033698 GO:0033697 biolink:BiologicalProcess obsolete positive regulation of extent of heterochromatin assembly OBSOLETE. Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin. go.json positive regulation of extent of heterochromatin formation|positive regulation of heterochromatin spreading True http://purl.obolibrary.org/obo/GO_0033697 GO:0033696 biolink:BiologicalProcess heterochromatin boundary formation A process that forms a boundary that limits the spreading of heterochromatin along a chromosome. go.json maintenance of heterochromatin boundaries|negative regulation of extent of heterochromatin assembly|negative regulation of extent of heterochromatin formation|negative regulation of heterochromatin spreading|regulation of extent of heterochromatin assembly|regulation of extent of heterochromatin formation|regulation of heterochromatin spreading http://purl.obolibrary.org/obo/GO_0033696 GO:0033695 biolink:MolecularActivity oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule. EC:1.17.5.- go.json http://purl.obolibrary.org/obo/GO_0033695 GO:0018076 biolink:BiologicalProcess N-terminal peptidyl-lysine acetylation The acetylation of the N-terminal lysine of proteins. go.json http://purl.obolibrary.org/obo/GO_0018076 gocheck_do_not_annotate GO:0018075 biolink:BiologicalProcess obsolete peptidyl-phenylalanine bromination OBSOLETE. The bromination of phenylalanine. RESID:AA0174|RESID:AA0175|RESID:AA0176 go.json True http://purl.obolibrary.org/obo/GO_0018075 GO:0033694 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.5.7.- go.json http://purl.obolibrary.org/obo/GO_0033694 GO:0018078 biolink:BiologicalProcess obsolete peptidyl-thyronine iodination OBSOLETE. The iodination of peptidyl-thyronine, formed from tyrosine. RESID:AA0177|RESID:AA0178 go.json True http://purl.obolibrary.org/obo/GO_0018078 GO:0033693 biolink:BiologicalProcess neurofilament bundle assembly The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules. go.json NF bundle assembly http://purl.obolibrary.org/obo/GO_0033693 GO:0033692 biolink:BiologicalProcess obsolete cellular polysaccharide biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. go.json cellular glycan biosynthesis|cellular glycan biosynthetic process|cellular polysaccharide anabolism|cellular polysaccharide biosynthesis|cellular polysaccharide formation|cellular polysaccharide synthesis True http://purl.obolibrary.org/obo/GO_0033692 GO:0018077 biolink:BiologicalProcess obsolete protein iodination OBSOLETE. The addition of one or more iodine atoms to an amino acid residue in a protein. go.json protein amino acid iodination True http://purl.obolibrary.org/obo/GO_0018077 GO:0018050 biolink:BiologicalProcess obsolete C-terminal peptidyl-threonine amidation OBSOLETE. The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein. RESID:AA0097 go.json True http://purl.obolibrary.org/obo/GO_0018050 GO:0018052 biolink:BiologicalProcess obsolete C-terminal peptidyl-tyrosine amidation OBSOLETE. The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein. RESID:AA0099 go.json True http://purl.obolibrary.org/obo/GO_0018052 GO:0018051 biolink:BiologicalProcess obsolete C-terminal peptidyl-tryptophan amidation OBSOLETE. The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein. RESID:AA0098 go.json True http://purl.obolibrary.org/obo/GO_0018051 GO:0033689 biolink:BiologicalProcess negative regulation of osteoblast proliferation Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation. go.json down regulation of osteoblast proliferation|down-regulation of osteoblast proliferation|downregulation of osteoblast proliferation|inhibition of osteoblast proliferation http://purl.obolibrary.org/obo/GO_0033689 GO:0033680 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033680 GO:0033688 biolink:BiologicalProcess regulation of osteoblast proliferation Any process that modulates the frequency, rate or extent of osteoblast proliferation. go.json http://purl.obolibrary.org/obo/GO_0033688 GO:0018047 biolink:BiologicalProcess obsolete C-terminal peptidyl-phenylalanine amidation OBSOLETE. The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein. RESID:AA0094 go.json True http://purl.obolibrary.org/obo/GO_0018047 GO:0018046 biolink:BiologicalProcess obsolete C-terminal peptidyl-methionine amidation OBSOLETE. The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein. RESID:AA0093 go.json True http://purl.obolibrary.org/obo/GO_0018046 GO:0033687 biolink:BiologicalProcess osteoblast proliferation The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. go.json http://purl.obolibrary.org/obo/GO_0033687 GO:0018049 biolink:BiologicalProcess obsolete C-terminal peptidyl-serine amidation OBSOLETE. The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein. RESID:AA0096 go.json True http://purl.obolibrary.org/obo/GO_0018049 GO:0033686 biolink:BiologicalProcess positive regulation of luteinizing hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone. go.json activation of luteinizing hormone secretion|stimulation of luteinizing hormone secretion|up regulation of luteinizing hormone secretion|up-regulation of luteinizing hormone secretion|upregulation of luteinizing hormone secretion http://purl.obolibrary.org/obo/GO_0033686 GO:0018048 biolink:BiologicalProcess obsolete C-terminal peptidyl-proline amidation OBSOLETE. The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein. RESID:AA0095 go.json True http://purl.obolibrary.org/obo/GO_0018048 GO:0033685 biolink:BiologicalProcess negative regulation of luteinizing hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone. go.json down regulation of luteinizing hormone secretion|down-regulation of luteinizing hormone secretion|downregulation of luteinizing hormone secretion|inhibition of luteinizing hormone secretion http://purl.obolibrary.org/obo/GO_0033685 GO:0018043 biolink:BiologicalProcess obsolete C-terminal peptidyl-isoleucine amidation OBSOLETE. The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein. RESID:AA0090 go.json True http://purl.obolibrary.org/obo/GO_0018043 GO:0033684 biolink:BiologicalProcess regulation of luteinizing hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone. go.json http://purl.obolibrary.org/obo/GO_0033684 GO:0018042 biolink:BiologicalProcess obsolete C-terminal peptidyl-histidine amidation OBSOLETE. The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein. RESID:AA0089 go.json True http://purl.obolibrary.org/obo/GO_0018042 GO:0033683 biolink:BiologicalProcess obsolete nucleotide-excision repair, DNA incision OBSOLETE. A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. go.json DNA incision involved in nucleotide-excision repair|nucleic acid cleavage involved in nucleotide-excision repair True http://purl.obolibrary.org/obo/GO_0033683 GO:0018045 biolink:BiologicalProcess obsolete C-terminal peptidyl-lysine amidation OBSOLETE. The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein. RESID:AA0092 go.json True http://purl.obolibrary.org/obo/GO_0018045 GO:0033682 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033682 GO:0018044 biolink:BiologicalProcess obsolete C-terminal peptidyl-leucine amidation OBSOLETE. The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein. RESID:AA0091 go.json True http://purl.obolibrary.org/obo/GO_0018044 GO:0033681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033681 GO:0018061 biolink:BiologicalProcess peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid. RESID:AA0128 go.json peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine|peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine|peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine http://purl.obolibrary.org/obo/GO_0018061 gocheck_do_not_annotate GO:0018060 biolink:BiologicalProcess N-terminal peptidyl-cysteine deamination The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. go.json http://purl.obolibrary.org/obo/GO_0018060 gocheck_do_not_annotate GO:0018063 biolink:BiologicalProcess cytochrome c-heme linkage The linkage of cytochromes and other heme proteins to heme. RESID:AA0134|RESID:AA0135 go.json cytochrome c-haem linkage http://purl.obolibrary.org/obo/GO_0018063 gocheck_do_not_annotate GO:0018062 biolink:BiologicalProcess peptidyl-tryptophan succinylation The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan. RESID:AA0130 go.json http://purl.obolibrary.org/obo/GO_0018062 gocheck_do_not_annotate GO:0033679 biolink:MolecularActivity 3'-5' DNA/RNA helicase activity Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis. go.json 3' to 5' DNA/RNA helicase activity|ATP-dependent 3' to 5' DNA/RNA helicase activity|ATP-dependent 3'-5' DNA/RNA helicase activity http://purl.obolibrary.org/obo/GO_0033679 GO:0033678 biolink:MolecularActivity 5'-3' DNA/RNA helicase activity Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis. Reactome:R-HSA-163120 go.json 5' to 3' DNA/RNA helicase activity|ATP-dependent 5' to 3' DNA/RNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity http://purl.obolibrary.org/obo/GO_0033678 GO:0033677 biolink:MolecularActivity DNA/RNA helicase activity Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis. go.json ATP-dependent DNA/RNA helicase activity http://purl.obolibrary.org/obo/GO_0033677 GO:0018058 biolink:BiologicalProcess N-terminal protein amino acid deamination, from amino carbon The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol. RESID:AA0127|RESID:AA0128|RESID:AA0129 go.json http://purl.obolibrary.org/obo/GO_0018058 gocheck_do_not_annotate GO:0018057 biolink:BiologicalProcess peptidyl-lysine oxidation The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens. RESID:AA0121 go.json http://purl.obolibrary.org/obo/GO_0018057 gocheck_do_not_annotate GO:0033676 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033676 GO:0033675 biolink:CellularComponent pericanalicular vesicle A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes. go.json http://purl.obolibrary.org/obo/GO_0033675 GO:0033674 biolink:BiologicalProcess positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. go.json kinase activator|stimulation of kinase activity|up regulation of kinase activity|up-regulation of kinase activity|upregulation of kinase activity http://purl.obolibrary.org/obo/GO_0033674 gocheck_do_not_annotate GO:0018059 biolink:BiologicalProcess N-terminal peptidyl-serine deamination The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. go.json http://purl.obolibrary.org/obo/GO_0018059 gocheck_do_not_annotate GO:0018054 biolink:BiologicalProcess obsolete peptidyl-lysine biotinylation OBSOLETE. The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine. RESID:AA0117 go.json True http://purl.obolibrary.org/obo/GO_0018054 GO:0033673 biolink:BiologicalProcess negative regulation of kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. go.json down regulation of kinase activity|down-regulation of kinase activity|downregulation of kinase activity|inhibition of kinase activity|kinase inhibitor http://purl.obolibrary.org/obo/GO_0033673 gocheck_do_not_annotate GO:0018053 biolink:BiologicalProcess obsolete C-terminal peptidyl-valine amidation OBSOLETE. The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein. RESID:AA0100 go.json True http://purl.obolibrary.org/obo/GO_0018053 GO:0033672 biolink:BiologicalProcess positive regulation of NAD+ kinase activity Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. go.json NAD+ kinase activator|stimulation of NAD+ kinase activity|up regulation of NAD+ kinase activity|up-regulation of NAD+ kinase activity|upregulation of NAD+ kinase activity http://purl.obolibrary.org/obo/GO_0033672 gocheck_do_not_annotate GO:0033671 biolink:BiologicalProcess negative regulation of NAD+ kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. go.json NAD+ kinase inhibitor|down regulation of NAD+ kinase activity|down-regulation of NAD+ kinase activity|downregulation of NAD+ kinase activity|inhibition of NAD+ kinase activity http://purl.obolibrary.org/obo/GO_0033671 gocheck_do_not_annotate GO:0018056 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018056 GO:0033670 biolink:BiologicalProcess regulation of NAD+ kinase activity Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. go.json NAD kinase regulator|regulation of NAD kinase activity http://purl.obolibrary.org/obo/GO_0033670 gocheck_do_not_annotate GO:0018055 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0018055 GO:0018030 biolink:MolecularActivity peptidyl-lysine N6-myristoyltransferase activity Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. go.json http://purl.obolibrary.org/obo/GO_0018030 GO:0033669 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0033669 GO:0033668 biolink:BiologicalProcess symbiont-mediated suppression of host apoptosis A process in which a symbiont gene product inhibits host apoptosis, leading to a decrease in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by organism of host apoptotic programmed cell death|down-regulation by organism of host apoptotic programmed cell death|downregulation by organism of host apoptotic programmed cell death|inhibition by organism of host apoptotic programmed cell death|negative regulation by symbiont of host apoptosis|negative regulation by symbiont of host apoptotic process|suppression by symbiont of host apoptotic process http://purl.obolibrary.org/obo/GO_0033668 GO:0033667 biolink:BiologicalProcess obsolete negative regulation of growth or development of symbiont in host OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json down regulation of growth or development of organism within host|down-regulation of growth or development of organism within host|downregulation of growth or development of organism within host|inhibition of growth of development of organism within host|negative regulation of growth or development of symbiont in host|negative regulation of growth or development of symbiont within host|negative regulation of invasive growth True http://purl.obolibrary.org/obo/GO_0033667 GO:0018029 biolink:BiologicalProcess peptidyl-lysine palmitoylation The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine. RESID:AA0077 go.json http://purl.obolibrary.org/obo/GO_0018029 gocheck_do_not_annotate GO:0018028 biolink:BiologicalProcess peptidyl-lysine myristoylation The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine. RESID:AA0078 go.json peptidyl-lysine myristylation http://purl.obolibrary.org/obo/GO_0018028 gocheck_do_not_annotate GO:0033666 biolink:BiologicalProcess obsolete positive regulation of growth or development of symbiont in host OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json positive regulation of growth or development of symbiont in host|positive regulation of growth or development of symbiont within host|positive regulation of invasive growth|up regulation of growth or development of organism within host|up-regulation of growth or development of organism within host|upregulation of growth or development of organism within host True http://purl.obolibrary.org/obo/GO_0033666 GO:0018025 biolink:MolecularActivity calmodulin-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. EC:2.1.1.60|MetaCyc:2.1.1.60-RXN|RHEA:21556|Reactome:R-HSA-6786205 go.json S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity|S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity|S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0018025 GO:0033665 biolink:BiologicalProcess obsolete regulation of growth or development of symbiont in host OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction. go.json modulation of growth or development of organism within host|modulation of growth or development of symbiont within host|modulation of invasive growth|regulation of growth or development of symbiont in host|regulation of growth or development of symbiont within host True http://purl.obolibrary.org/obo/GO_0033665 GO:0018024 biolink:MolecularActivity obsolete histone lysine N-methyltransferase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. go.json S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity|S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity|histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity|histone-lysine N-methylase activity|histone-lysine N-methyltransferase activity True http://purl.obolibrary.org/obo/GO_0018024 GO:0033664 biolink:BiologicalProcess obsolete positive regulation by symbiont of host defense-related protein level OBSOLETE. Any process in which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0033664 GO:0018027 biolink:BiologicalProcess peptidyl-lysine dimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. RESID:AA0075 go.json http://purl.obolibrary.org/obo/GO_0018027 gocheck_do_not_annotate GO:0018026 biolink:BiologicalProcess peptidyl-lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. RESID:AA0076 go.json http://purl.obolibrary.org/obo/GO_0018026 gocheck_do_not_annotate GO:0033663 biolink:BiologicalProcess obsolete negative regulation by symbiont of host defense-related protein level OBSOLETE. Any process in which the symbiont reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0033663 GO:0018021 biolink:BiologicalProcess peptidyl-histidine methylation The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). RESID:AA0073|RESID:AA0317 go.json http://purl.obolibrary.org/obo/GO_0018021 gocheck_do_not_annotate GO:0033662 biolink:BiologicalProcess obsolete modulation by symbiont of host defense-related protein level OBSOLETE. The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0033662 GO:0033661 biolink:BiologicalProcess effector-mediated defense to host-produced reactive oxygen species A process mediated by a molecule secreted by a symbiont that results in the suppression of reactive oxygen species produced by the host as part of its innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by organism of defense-related host metabolic burst|down-regulation by organism of defense-related host oxidative burst|downregulation by organism of defense-related host AOS production|negative regulation by organism of defense-related host ROI production|negative regulation by organism of defense-related host ROS production|negative regulation by organism of defense-related host reactive oxidative species production|negative regulation by organism of defense-related host reactive oxygen intermediate production|negative regulation by organism of defense-related host respiratory burst|negative regulation by symbiont of defense-related host reactive oxygen species production|suppression by symbiont of defense-related host reactive oxygen species production http://purl.obolibrary.org/obo/GO_0033661 GO:0018020 biolink:BiologicalProcess peptidyl-glutamic acid methylation The addition of a methyl group to a glutamic acid residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0018020 gocheck_do_not_annotate GO:0033660 biolink:BiologicalProcess suppression by symbiont of host resistance gene-dependent defense response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of defense response in host by specific elicitors|down-regulation by symbiont of host gene-for-gene resistance|downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont|inhibition by symbiont of host resistance gene-dependent defense response|negative regulation by symbiont of host resistance gene-dependent defense response http://purl.obolibrary.org/obo/GO_0033660 GO:0018023 biolink:BiologicalProcess peptidyl-lysine trimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. RESID:AA0074 go.json http://purl.obolibrary.org/obo/GO_0018023 gocheck_do_not_annotate GO:0018022 biolink:BiologicalProcess peptidyl-lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. go.json http://purl.obolibrary.org/obo/GO_0018022 gocheck_do_not_annotate GO:0018041 biolink:BiologicalProcess obsolete C-terminal peptidyl-glycine amidation OBSOLETE. The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein. RESID:AA0088 go.json True http://purl.obolibrary.org/obo/GO_0018041 GO:0018040 biolink:BiologicalProcess obsolete C-terminal peptidyl-glutamic acid amidation OBSOLETE. The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein. RESID:AA0087 go.json True http://purl.obolibrary.org/obo/GO_0018040 GO:0033659 biolink:BiologicalProcess symbiont-mediated disruption of host mitochondrion The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host mitochondrion|modification by symbiont of host mitochondrion http://purl.obolibrary.org/obo/GO_0033659 GO:0033658 biolink:BiologicalProcess symbiont-mediated disruption of host chloroplast thylakoid The process in which an organism effects a change that impairs the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host chloroplast thylakoid|modification by symbiont of host chloroplast thylakoid http://purl.obolibrary.org/obo/GO_0033658 GO:0033657 biolink:BiologicalProcess obsolete disruption by symbiont of host chloroplast part OBSOLETE. The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification by symbiont of host chloroplast part True http://purl.obolibrary.org/obo/GO_0033657 GO:0033656 biolink:BiologicalProcess symbiont-mediated disruption of host chloroplast The process in which an organism effects a change that impairs the structure or function of the host chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host chloroplast|modification by symbiont of host chloroplast http://purl.obolibrary.org/obo/GO_0033656 GO:0018039 biolink:BiologicalProcess obsolete C-terminal peptidyl-glutamine amidation OBSOLETE. The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein. RESID:AA0086 go.json True http://purl.obolibrary.org/obo/GO_0018039 GO:0018036 biolink:BiologicalProcess obsolete C-terminal peptidyl-asparagine amidation OBSOLETE. The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein. RESID:AA0083 go.json True http://purl.obolibrary.org/obo/GO_0018036 GO:0033655 biolink:CellularComponent host cell cytoplasm part Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json cytoplasm component http://purl.obolibrary.org/obo/GO_0033655 gocheck_do_not_annotate GO:0018035 biolink:BiologicalProcess obsolete C-terminal peptidyl-arginine amidation OBSOLETE. The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein. RESID:AA0082 go.json True http://purl.obolibrary.org/obo/GO_0018035 GO:0033654 biolink:CellularComponent host cell chloroplast thylakoid membrane Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033654 GO:0018038 biolink:BiologicalProcess obsolete C-terminal peptidyl-cysteine amidation OBSOLETE. The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein. RESID:AA0085 go.json True http://purl.obolibrary.org/obo/GO_0018038 GO:0033653 biolink:CellularComponent host cell chloroplast part Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json host chloroplast component http://purl.obolibrary.org/obo/GO_0033653 gocheck_do_not_annotate GO:0018037 biolink:BiologicalProcess obsolete C-terminal peptidyl-aspartic acid amidation OBSOLETE. The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein. RESID:AA0084 go.json True http://purl.obolibrary.org/obo/GO_0018037 GO:0033652 biolink:CellularComponent host cell chloroplast A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033652 GO:0018032 biolink:BiologicalProcess protein amidation Addition of an amide group from a glycine to a protein amino acid. go.json protein amino acid amidation http://purl.obolibrary.org/obo/GO_0018032 gocheck_do_not_annotate GO:0033651 biolink:CellularComponent host cell plastid Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0033651 GO:0018031 biolink:MolecularActivity peptidyl-lysine N6-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. go.json http://purl.obolibrary.org/obo/GO_0018031 GO:0033650 biolink:CellularComponent host cell mitochondrion A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json host mitochondria http://purl.obolibrary.org/obo/GO_0033650 GO:0018034 biolink:BiologicalProcess obsolete C-terminal peptidyl-alanine amidation OBSOLETE. The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein. RESID:AA0081 go.json True http://purl.obolibrary.org/obo/GO_0018034 GO:0018033 biolink:BiologicalProcess obsolete protein C-terminal amidation OBSOLETE. The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein. go.json True http://purl.obolibrary.org/obo/GO_0018033 GO:0008608 biolink:BiologicalProcess attachment of spindle microtubules to kinetochore The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. go.json amphotelic attachment|attachment of spindle microtubules to chromosome|bipolar attachment|kinetochore microtubule interaction|kinetochore-microtubule attachment|kinetochore-microtubule interaction|microtubule anchoring at kinetochore|microtubule and chromosome interaction|microtubule and kinetochore interaction|microtubule capture|spindle chromosome attachment|spindle kinetochore attachment|spindle-chromosome interaction http://purl.obolibrary.org/obo/GO_0008608 GO:0008607 biolink:MolecularActivity phosphorylase kinase regulator activity Modulation of the activity of the enzyme phosphorylase kinase. go.json phosphorylase kinase, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0008607 GO:0008606 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008606 GO:0008605 biolink:MolecularActivity obsolete protein kinase CK2 regulator activity OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2. go.json casein kinase II, regulator|protein kinase CK2 regulator activity|protein kinase CK2, intrinsic regulator activity True http://purl.obolibrary.org/obo/GO_0008605 GO:0008604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008604 GO:0008603 biolink:MolecularActivity cAMP-dependent protein kinase regulator activity Modulation of the activity of the enzyme cAMP-dependent protein kinase. go.json 3',5' cAMP-dependent protein kinase regulator activity|3',5'-cAMP-dependent protein kinase regulator activity|adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity|cAMP-dependent protein kinase, intrinsic regulator activity|cyclic AMP-dependent protein kinase regulator activity http://purl.obolibrary.org/obo/GO_0008603 GO:0008602 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008602 GO:0008601 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008601 GO:0008600 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0008600 GO:0008609 biolink:MolecularActivity alkylglycerone-phosphate synthase activity Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. EC:2.5.1.26|MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN|RHEA:36171|Reactome:R-HSA-390427 go.json 1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity|DHAP-AT|alkyl DHAP synthetase activity|alkyl-DHAP|alkyl-DHAP synthase activity|alkyldihydroxyacetone phosphate synthetase activity|alkyldihydroxyacetonephosphate synthase activity|dihydroxyacetone-phosphate acyltransferase activity http://purl.obolibrary.org/obo/GO_0008609 GO:0008619 biolink:MolecularActivity obsolete RHEB small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json RHEB small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0008619 GO:0008618 biolink:BiologicalProcess 7-methylguanosine metabolic process The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. go.json 7-methylguanosine metabolism http://purl.obolibrary.org/obo/GO_0008618 GO:0008617 biolink:BiologicalProcess guanosine metabolic process The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution. go.json guanosine metabolism http://purl.obolibrary.org/obo/GO_0008617 GO:0008616 biolink:BiologicalProcess queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. go.json queuosine anabolism|queuosine biosynthesis|queuosine formation|queuosine synthesis http://purl.obolibrary.org/obo/GO_0008616 GO:0008615 biolink:BiologicalProcess pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. go.json pyridoxine anabolism|pyridoxine biosynthesis|pyridoxine formation|pyridoxine synthesis http://purl.obolibrary.org/obo/GO_0008615 GO:0008614 biolink:BiologicalProcess pyridoxine metabolic process The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json pyridoxine metabolism http://purl.obolibrary.org/obo/GO_0008614 GO:0008613 biolink:MolecularActivity diuretic hormone activity The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. go.json http://purl.obolibrary.org/obo/GO_0008613 GO:0008612 biolink:BiologicalProcess peptidyl-lysine modification to peptidyl-hypusine The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine. RESID:AA0116 go.json hypusine anabolism|hypusine anabolism from peptidyl-lysine|hypusine biosynthesis|hypusine biosynthetic process|hypusine biosynthetic process from peptidyl-lysine|hypusine formation|hypusine formation from peptidyl-lysine|hypusine synthesis|hypusine synthesis from peptidyl-lysine|hypusinylation|protein hypusination http://purl.obolibrary.org/obo/GO_0008612 gocheck_do_not_annotate GO:0008611 biolink:BiologicalProcess ether lipid biosynthetic process The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. go.json ether lipid anabolism|ether lipid biosynthesis|ether lipid formation|ether lipid synthesis|plasmalogen biosynthetic process http://purl.obolibrary.org/obo/GO_0008611 GO:0008610 biolink:BiologicalProcess lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. go.json lipid anabolism|lipid biosynthesis|lipid formation|lipid synthesis|lipogenesis http://purl.obolibrary.org/obo/GO_0008610 GO:0003953 biolink:MolecularActivity NAD+ nucleosidase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. RHEA:16301|Reactome:R-HSA-8870346|Reactome:R-HSA-8938076 go.json NAD nucleosidase activity http://purl.obolibrary.org/obo/GO_0003953 GO:0003952 biolink:MolecularActivity NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. EC:6.3.5.1|MetaCyc:NAD-SYNTH-GLN-RXN|RHEA:24384|Reactome:R-HSA-197271|Wikipedia:NAD+_synthase_(glutamine-hydrolysing) go.json DPN synthetase activity|NAD synthase (glutamine-hydrolyzing) activity|NAD synthetase (glutamine-hydrolysing)|NAD(+) synthetase (glutamine-hydrolyzing) activity|NAD+ synthase (glutamine-hydrolysing)|NAD+ synthetase (glutamine-hydrolyzing)|deamido-NAD+:L-glutamine amido-ligase (AMP-forming)|desamidonicotinamide adenine dinucleotide amidotransferase activity|nicotinamide adenine dinucleotide synthetase (glutamine) activity http://purl.obolibrary.org/obo/GO_0003952 GO:0003955 biolink:MolecularActivity NAD(P)H dehydrogenase (quinone) activity Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone. EC:1.6.5.2|MetaCyc:NQOR-RXN|UM-BBD_reactionID:r0227 go.json DT-diaphorase activity|NAD(P)H dehydrogenase activity|NAD(P)H menadione reductase activity|NAD(P)H(2) dehydrogenase (quinone) activity|NAD(P)H-quinone dehydrogenase activity|NAD(P)H-quinone oxidoreductase activity|NAD(P)H2 dehydrogenase (quinone)|NAD(P)H: menadione oxidoreductase activity|NAD(P)H:(quinone-acceptor)oxidoreductase activity|NAD(P)H:quinone oxidoreductase activity|NADH-menadione reductase activity|NQO1|QR1|azoreductase activity|dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity|diaphorase activity|flavoprotein NAD(P)H-quinone reductase activity|menadione oxidoreductase activity|menadione reductase activity|naphthoquinone reductase activity|p-benzoquinone reductase activity|phylloquinone reductase activity|quinone reductase activity|reduced NAD(P)H dehydrogenase activity|reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity|viologen accepting pyridine nucleotide oxidoreductase activity|vitamin K reductase activity|vitamin-K reductase activity http://purl.obolibrary.org/obo/GO_0003955 GO:0003954 biolink:MolecularActivity NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. RHEA:11356 go.json DPNH diaphorase activity|NADH diaphorase activity|NADH hydrogenase activity|NADH oxidoreductase activity|NADH-menadione oxidoreductase activity|NADH2 dehydrogenase activity|NADH:(acceptor) oxidoreductase activity|NADH:acceptor oxidoreductase activity|NADH:cytochrome c oxidoreductase activity|beta-NADH dehydrogenase dinucleotide activity|cytochrome c reductase activity|diaphorase activity|dihydrocodehydrogenase I dehydrogenase activity|dihydronicotinamide adenine dinucleotide dehydrogenase activity|diphosphopyridine diaphorase activity|diphosphopyrinase activity|reduced diphosphopyridine nucleotide diaphorase activity|type 1 dehydrogenase activity|type I dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003954 GO:0003951 biolink:MolecularActivity NAD+ kinase activity Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+. EC:2.7.1.23|KEGG_REACTION:R00104|MetaCyc:NAD-KIN-RXN|RHEA:18629|Reactome:R-HSA-197198|Reactome:R-HSA-8955030 go.json ATP:NAD+ 2'-phosphotransferase activity|DPN kinase activity|NAD kinase activity|NADK|nicotinamide adenine dinucleotide kinase (phosphorylating)|nicotinamide adenine dinucleotide kinase activity http://purl.obolibrary.org/obo/GO_0003951 GO:0003950 biolink:MolecularActivity NAD+ ADP-ribosyltransferase activity Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. EC:2.4.2.30|MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN|Reactome:R-HSA-2187325|Reactome:R-HSA-3640858|Reactome:R-HSA-5651723|Reactome:R-HSA-5687653|Reactome:R-HSA-5688276|Reactome:R-HSA-8938073|Reactome:R-HSA-8948800|Reactome:R-HSA-9686061|Reactome:R-HSA-9729279 go.json ADP-ribosyltransferase (polymerizing) activity|NAD ADP-ribosyltransferase activity|NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|poly(ADP-ribose) synthase activity|poly(ADP-ribose) synthetase activity|poly(ADP-ribose)polymerase activity|poly(adenosine diphosphate ribose) polymerase activity http://purl.obolibrary.org/obo/GO_0003950 GO:1904679 biolink:BiologicalProcess myo-inositol import across plasma membrane The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol. go.json myo-inositol import into cell http://purl.obolibrary.org/obo/GO_1904679 GO:1904678 biolink:MolecularActivity alpha-aminoacyl-tRNA binding Binding to an alpha-aminoacyl-tRNA. go.json aminoacyl-tRNA binding http://purl.obolibrary.org/obo/GO_1904678 GO:1904677 biolink:BiologicalProcess positive regulation of somatic stem cell division Any process that activates or increases the frequency, rate or extent of somatic stem cell division. go.json activation of somatic stem cell division|activation of somatic stem cell renewal|positive regulation of somatic stem cell renewal|up regulation of somatic stem cell division|up regulation of somatic stem cell renewal|up-regulation of somatic stem cell division|up-regulation of somatic stem cell renewal|upregulation of somatic stem cell division|upregulation of somatic stem cell renewal http://purl.obolibrary.org/obo/GO_1904677 GO:1904676 biolink:BiologicalProcess negative regulation of somatic stem cell division Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. go.json down regulation of somatic stem cell division|down regulation of somatic stem cell renewal|down-regulation of somatic stem cell division|down-regulation of somatic stem cell renewal|downregulation of somatic stem cell division|downregulation of somatic stem cell renewal|inhibition of somatic stem cell division|inhibition of somatic stem cell renewal|negative regulation of somatic stem cell renewal http://purl.obolibrary.org/obo/GO_1904676 GO:1904675 biolink:BiologicalProcess regulation of somatic stem cell division Any process that modulates the frequency, rate or extent of somatic stem cell division. go.json regulation of somatic stem cell renewal http://purl.obolibrary.org/obo/GO_1904675 GO:1904674 biolink:BiologicalProcess positive regulation of somatic stem cell population maintenance Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance. go.json activation of somatic stem cell population maintenance|up regulation of somatic stem cell population maintenance|up-regulation of somatic stem cell population maintenance|upregulation of somatic stem cell population maintenance http://purl.obolibrary.org/obo/GO_1904674 GO:1904684 biolink:BiologicalProcess negative regulation of metalloendopeptidase activity Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity. go.json down regulation of metalloendopeptidase activity|down regulation of metalloendoprotease activity|down regulation of metalloendoproteinase activity|down-regulation of metalloendopeptidase activity|down-regulation of metalloendoprotease activity|down-regulation of metalloendoproteinase activity|downregulation of metalloendopeptidase activity|downregulation of metalloendoprotease activity|downregulation of metalloendoproteinase activity|inhibition of metalloendopeptidase activity|inhibition of metalloendoprotease activity|inhibition of metalloendoproteinase activity|negative regulation of metalloendoprotease activity|negative regulation of metalloendoproteinase activity http://purl.obolibrary.org/obo/GO_1904684 gocheck_do_not_annotate GO:1904683 biolink:BiologicalProcess regulation of metalloendopeptidase activity Any process that modulates the frequency, rate or extent of metalloendopeptidase activity. go.json regulation of metalloendoprotease activity|regulation of metalloendoproteinase activity http://purl.obolibrary.org/obo/GO_1904683 gocheck_do_not_annotate GO:1904682 biolink:BiologicalProcess cellular response to 3-methylcholanthrene Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus. go.json http://purl.obolibrary.org/obo/GO_1904682 GO:1904681 biolink:BiologicalProcess response to 3-methylcholanthrene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus. go.json http://purl.obolibrary.org/obo/GO_1904681 GO:1904680 biolink:MolecularActivity peptide transmembrane transporter activity Enables the transfer of a peptide from one side of a membrane to the other. Reactome:R-HSA-1500817 go.json peptide transporter activity|peptide uptake permease activity http://purl.obolibrary.org/obo/GO_1904680 GO:0003957 biolink:MolecularActivity NAD(P)+ transhydrogenase (B-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. EC:1.6.1.1|MetaCyc:PYRNUTRANSHYDROGEN-RXN go.json H+-thase|NAD transhydrogenase|NAD(P) transhydrogenase (B-specific) activity|NADH transhydrogenase|NADH-NADP-transhydrogenase|NADPH-NAD oxidoreductase|NADPH-NAD transhydrogenase|NADPH:NAD+ oxidoreductase (B-specific)|NADPH:NAD+ transhydrogenase|nicotinamide adenine dinucleotide (phosphate) transhydrogenase|nicotinamide nucleotide transhydrogenase activity|non-energy-linked transhydrogenase activity|pyridine nucleotide transferase|pyridine nucleotide transhydrogenase activity http://purl.obolibrary.org/obo/GO_0003957 GO:0003956 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003956 GO:0003959 biolink:MolecularActivity NADPH dehydrogenase activity Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. EC:1.6.99.1|MetaCyc:NADPH-DEHYDROGENASE-RXN|RHEA:13149|Reactome:R-HSA-9018867|Reactome:R-HSA-9018901|Reactome:R-HSA-9027625|Reactome:R-HSA-9027631|Reactome:R-HSA-9027632|UM-BBD_enzymeID:e0523 go.json NADPH diaphorase activity|NADPH-dehydrogenase activity|NADPH2 diaphorase activity|NADPH2-dehydrogenase activity|NADPH:(acceptor) oxidoreductase activity|NADPH:acceptor oxidoreductase activity|OYE|TPNH dehydrogenase activity|TPNH-diaphorase activity|dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity|old yellow enzyme|reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity|triphosphopyridine diaphorase activity|triphosphopyridine nucleotide diaphorase activity http://purl.obolibrary.org/obo/GO_0003959 GO:0003958 biolink:MolecularActivity NADPH-hemoprotein reductase activity Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. EC:1.6.2.4|MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN|RHEA:24040|Reactome:R-HSA-76494 go.json CPR activity|FAD-cytochrome c reductase activity|NADP--cytochrome c reductase activity|NADP--cytochrome reductase activity|NADPH--cytochrome P450 oxidoreductase activity|NADPH--cytochrome P450 reductase activity|NADPH--cytochrome c oxidoreductase activity|NADPH--cytochrome c reductase activity|NADPH--ferricytochrome c oxidoreductase activity|NADPH--ferrihemoprotein reductase activity|NADPH-cytochrome P-450 oxidoreductase activity|NADPH-cytochrome p-450 reductase activity|NADPH-dependent cytochrome c reductase activity|NADPH-ferrihemoprotein reductase activity|NADPH:P-450 reductase activity|NADPH:P450 reductase activity|NADPH:cytochrome P450 reductase activity|NADPH:cytochrome c reductase activity|NADPH:ferrihemoprotein oxidoreductase activity|NADPH:hemoprotein oxidoreductase activity|POR|TPNH(2) cytochrome c reductase activity|TPNH-cytochrome c reductase activity|TPNH2 cytochrome c reductase activity|aldehyde reductase (NADPH-dependent) activity|cytochrome P-450 reductase activity|cytochrome P450 reductase activity|cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity|dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity|ferrihemoprotein P-450 reductase activity|reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity|reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity http://purl.obolibrary.org/obo/GO_0003958 GO:0003964 biolink:MolecularActivity RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. EC:2.7.7.49|MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN|Reactome:R-HSA-164504|Reactome:R-HSA-164520 go.json DNA nucleotidyltransferase (RNA-directed) activity|RNA revertase activity|RNA-dependent DNA polymerase activity|RNA-dependent deoxyribonucleate nucleotidyltransferase activity|RNA-directed DNA polymerase, group II intron encoded|RNA-directed DNA polymerase, transposon encoded|RNA-instructed DNA polymerase activity|RT|deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity|reverse transcriptase activity|revertase activity http://purl.obolibrary.org/obo/GO_0003964 GO:0003963 biolink:MolecularActivity RNA-3'-phosphate cyclase activity Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. EC:6.5.1.4|MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN|RHEA:23976 go.json RNA 3'-terminal phosphate cyclase activity|RNA cyclase activity|RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming) http://purl.obolibrary.org/obo/GO_0003963 GO:0003966 biolink:MolecularActivity obsolete RNA-directed DNA polymerase, transposon encoded OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. go.json RNA-directed DNA polymerase, transposon encoded True http://purl.obolibrary.org/obo/GO_0003966 GO:0003960 biolink:MolecularActivity NADPH:quinone reductase activity Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. EC:1.6.5.5|MetaCyc:QOR-RXN|RHEA:14269|Reactome:R-HSA-6799722 go.json NADPH:quinone oxidoreductase activity|quinone oxidoreductase activity|zeta-crystallin activity http://purl.obolibrary.org/obo/GO_0003960 GO:0003962 biolink:MolecularActivity cystathionine gamma-synthase activity Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. EC:2.5.1.48|MetaCyc:O-SUCCHOMOSERLYASE-RXN|RHEA:20397 go.json CTT gamma synthase activity|O-succinyl-L-homoserine (thiol)-lyase activity|O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity|O-succinyl-L-homoserine succinate-lyase activity|O-succinylhomoserine (thiol)-lyase activity|O-succinylhomoserine synthase activity|O-succinylhomoserine synthetase activity|O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity|cystathionine g-synthase activity|cystathionine gamma synthase activity|cystathionine synthase activity|cystathionine synthetase activity|homoserine O-transsuccinylase activity|homoserine transsuccinylase activity http://purl.obolibrary.org/obo/GO_0003962 GO:0003961 biolink:MolecularActivity O-acetylhomoserine aminocarboxypropyltransferase activity Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers. EC:2.5.1.49|MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN|RHEA:10048 go.json L-methionine anabolism, direct, from O-acetyl-L-homoserine|L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine|L-methionine formation, direct, from O-acetyl-L-homoserine|L-methionine synthesis, direct, from O-acetyl-L-homoserine|O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity|O-acetyl-L-homoserine sulfhydrolase activity|O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity|O-acetylhomoserine (thiol)-lyase activity|O-acetylhomoserine sulfhydrolase activity|OAH sulfhydrylase activity|methionine biosynthetic process, direct, from O-acetyl-L-homoserine http://purl.obolibrary.org/obo/GO_0003961 GO:0062240 biolink:MolecularActivity euchromatin-nuclear membrane anchor activity Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization. go.json euchromatin-nuclear membrane tether activity|nuclear membrane-euchromatin anchor activity|nuclear membrane-euchromatin tether activity http://purl.obolibrary.org/obo/GO_0062240 GO:1904689 biolink:BiologicalProcess negative regulation of cytoplasmic translational initiation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation. go.json down regulation of cytoplasmic translational initiation|down-regulation of cytoplasmic translational initiation|downregulation of cytoplasmic translational initiation|inhibition of cytoplasmic translational initiation http://purl.obolibrary.org/obo/GO_1904689 GO:1904688 biolink:BiologicalProcess regulation of cytoplasmic translational initiation Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation. go.json http://purl.obolibrary.org/obo/GO_1904688 GO:0062242 biolink:CellularComponent double membrane vesicle viral factory membrane One of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. go.json membrane of double membrane vesicle viral factory http://purl.obolibrary.org/obo/GO_0062242 GO:1904687 biolink:BiologicalProcess positive regulation of mitotic spindle disassembly Any process that activates or increases the frequency, rate or extent of mitotic spindle disassembly. go.json activation of mitotic spindle breakdown|activation of mitotic spindle catabolism|activation of mitotic spindle degradation|activation of mitotic spindle disassembly|activation of spindle breakdown during mitosis|activation of spindle degradation during mitosis|activation of spindle disassembly during mitosis|positive regulation of mitotic spindle breakdown|positive regulation of mitotic spindle catabolism|positive regulation of mitotic spindle degradation|positive regulation of spindle breakdown during mitosis|positive regulation of spindle degradation during mitosis|positive regulation of spindle disassembly during mitosis|up regulation of mitotic spindle breakdown|up regulation of mitotic spindle catabolism|up regulation of mitotic spindle degradation|up regulation of mitotic spindle disassembly|up regulation of spindle breakdown during mitosis|up regulation of spindle degradation during mitosis|up regulation of spindle disassembly during mitosis|up-regulation of mitotic spindle breakdown|up-regulation of mitotic spindle catabolism|up-regulation of mitotic spindle degradation|up-regulation of mitotic spindle disassembly|up-regulation of spindle breakdown during mitosis|up-regulation of spindle degradation during mitosis|up-regulation of spindle disassembly during mitosis|upregulation of mitotic spindle breakdown|upregulation of mitotic spindle catabolism|upregulation of mitotic spindle degradation|upregulation of mitotic spindle disassembly|upregulation of spindle breakdown during mitosis|upregulation of spindle degradation during mitosis|upregulation of spindle disassembly during mitosis http://purl.obolibrary.org/obo/GO_1904687 GO:0062241 biolink:MolecularActivity double strand break-nuclear membrane anchor activity Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair. go.json DNA repair factory http://purl.obolibrary.org/obo/GO_0062241 GO:1904686 biolink:BiologicalProcess regulation of mitotic spindle disassembly Any process that modulates the frequency, rate or extent of mitotic spindle disassembly. go.json regulation of mitotic spindle breakdown|regulation of mitotic spindle catabolism|regulation of mitotic spindle degradation|regulation of spindle breakdown during mitosis|regulation of spindle degradation during mitosis|regulation of spindle disassembly during mitosis http://purl.obolibrary.org/obo/GO_1904686 GO:0062244 biolink:CellularComponent double membrane vesicle viral factory lumen The volume surrounded by the inner membrane of a double membrane vesicle viral factory. go.json lumen of double membrane vesicle viral factory http://purl.obolibrary.org/obo/GO_0062244 GO:1904685 biolink:BiologicalProcess positive regulation of metalloendopeptidase activity Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity. go.json activation of metalloendopeptidase activity|activation of metalloendoprotease activity|activation of metalloendoproteinase activity|positive regulation of metalloendoprotease activity|positive regulation of metalloendoproteinase activity|up regulation of metalloendopeptidase activity|up regulation of metalloendoprotease activity|up regulation of metalloendoproteinase activity|up-regulation of metalloendopeptidase activity|up-regulation of metalloendoprotease activity|up-regulation of metalloendoproteinase activity|upregulation of metalloendopeptidase activity|upregulation of metalloendoprotease activity|upregulation of metalloendoproteinase activity http://purl.obolibrary.org/obo/GO_1904685 gocheck_do_not_annotate GO:0062243 biolink:CellularComponent double membrane vesicle viral factory outer membrane The outer of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. go.json outer membrane of double membrane vesicle viral factory http://purl.obolibrary.org/obo/GO_0062243 GO:0062246 biolink:CellularComponent exocytic vesicle lumen The volume enclosed by an exocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0062246 GO:1904695 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle contraction Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction. go.json activation of vascular smooth muscle contraction|positive regulation of vascular smooth muscle contraction|up regulation of vascular smooth muscle contraction|up-regulation of vascular smooth muscle contraction|upregulation of vascular smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904695 GO:0062245 biolink:CellularComponent double membrane vesicle viral factory inner membrane The inner of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. go.json inner membrane of double membrane vesicle viral factory http://purl.obolibrary.org/obo/GO_0062245 GO:1904694 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction. go.json down regulation of vascular smooth muscle contraction|down-regulation of vascular smooth muscle contraction|downregulation of vascular smooth muscle contraction|inhibition of vascular smooth muscle contraction|negative regulation of vascular smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904694 GO:1904693 biolink:BiologicalProcess midbrain morphogenesis The developmental process by which a midbrain is generated and organized. go.json MB morphogenesis|mesencephalon morphogenesis http://purl.obolibrary.org/obo/GO_1904693 GO:0062248 biolink:BiologicalProcess cleistothecium formation The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. go.json http://purl.obolibrary.org/obo/GO_0062248 GO:1904692 biolink:BiologicalProcess positive regulation of type B pancreatic cell proliferation Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. go.json activation of pancreatic B cell proliferation|activation of pancreatic beta cell proliferation|activation of type B pancreatic cell proliferation|positive regulation of pancreatic B cell proliferation|positive regulation of pancreatic beta cell proliferation|up regulation of pancreatic B cell proliferation|up regulation of pancreatic beta cell proliferation|up regulation of type B pancreatic cell proliferation|up-regulation of pancreatic B cell proliferation|up-regulation of pancreatic beta cell proliferation|up-regulation of type B pancreatic cell proliferation|upregulation of pancreatic B cell proliferation|upregulation of pancreatic beta cell proliferation|upregulation of type B pancreatic cell proliferation http://purl.obolibrary.org/obo/GO_1904692 GO:0062247 biolink:CellularComponent chloroplast vesicle A intracellular vesicle that is part of a chloroplast. go.json http://purl.obolibrary.org/obo/GO_0062247 GO:1904691 biolink:BiologicalProcess negative regulation of type B pancreatic cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. go.json down regulation of pancreatic B cell proliferation|down regulation of pancreatic beta cell proliferation|down regulation of type B pancreatic cell proliferation|down-regulation of pancreatic B cell proliferation|down-regulation of pancreatic beta cell proliferation|down-regulation of type B pancreatic cell proliferation|downregulation of pancreatic B cell proliferation|downregulation of pancreatic beta cell proliferation|downregulation of type B pancreatic cell proliferation|inhibition of pancreatic B cell proliferation|inhibition of pancreatic beta cell proliferation|inhibition of type B pancreatic cell proliferation|negative regulation of pancreatic B cell proliferation|negative regulation of pancreatic beta cell proliferation http://purl.obolibrary.org/obo/GO_1904691 GO:1904690 biolink:BiologicalProcess positive regulation of cytoplasmic translational initiation Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation. go.json activation of cytoplasmic translational initiation|up regulation of cytoplasmic translational initiation|up-regulation of cytoplasmic translational initiation|upregulation of cytoplasmic translational initiation http://purl.obolibrary.org/obo/GO_1904690 GO:0003968 biolink:MolecularActivity RNA-dependent RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. EC:2.7.7.48|MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN|Reactome:R-HSA-168280|Reactome:R-HSA-168301|Reactome:R-HSA-192624|Reactome:R-HSA-192832|Reactome:R-HSA-192851|Reactome:R-HSA-192916|Reactome:R-HSA-9681651|Reactome:R-HSA-9681674|Reactome:R-HSA-9681840|Reactome:R-HSA-9682465|Reactome:R-HSA-9682563|Reactome:R-HSA-9685639|Reactome:R-HSA-9685681|Reactome:R-HSA-9694277|Reactome:R-HSA-9694344|Reactome:R-HSA-9694506|Reactome:R-HSA-9694549|Reactome:R-HSA-9694581|Reactome:R-HSA-9694605|Reactome:R-HSA-9694792 go.json RNA nucleotidyltransferase (RNA-directed) activity|RNA replicase activity|RNA synthetase activity|RNA-dependent RNA replicase activity|RNA-directed 5'-3' RNA polymerase activity|RNA-directed RNA polymerase activity|RdRP activity|transcriptase http://purl.obolibrary.org/obo/GO_0003968 GO:0003967 biolink:MolecularActivity obsolete RNA-directed DNA polymerase, group II intron encoded OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. go.json RNA-directed DNA polymerase, group II intron encoded True http://purl.obolibrary.org/obo/GO_0003967 GO:0003969 biolink:MolecularActivity obsolete RNA editase activity OBSOLETE. (Was not defined before being made obsolete). go.json RNA editase activity True http://purl.obolibrary.org/obo/GO_0003969 GO:0003931 biolink:MolecularActivity obsolete Rho small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. go.json Rho small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0003931 GO:0003930 biolink:MolecularActivity obsolete RAS small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json RAS small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0003930 GO:0003933 biolink:MolecularActivity GTP cyclohydrolase activity Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. go.json http://purl.obolibrary.org/obo/GO_0003933 GO:0003932 biolink:MolecularActivity obsolete SAR small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json SAR small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0003932 GO:1904699 biolink:BiologicalProcess positive regulation of acinar cell proliferation Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. go.json activation of acinar cell proliferation|activation of acinic cell proliferation|activation of acinous cell proliferation|positive regulation of acinic cell proliferation|positive regulation of acinous cell proliferation|up regulation of acinar cell proliferation|up regulation of acinic cell proliferation|up regulation of acinous cell proliferation|up-regulation of acinar cell proliferation|up-regulation of acinic cell proliferation|up-regulation of acinous cell proliferation|upregulation of acinar cell proliferation|upregulation of acinic cell proliferation|upregulation of acinous cell proliferation http://purl.obolibrary.org/obo/GO_1904699 GO:1904698 biolink:BiologicalProcess negative regulation of acinar cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. go.json down regulation of acinar cell proliferation|down regulation of acinic cell proliferation|down regulation of acinous cell proliferation|down-regulation of acinar cell proliferation|down-regulation of acinic cell proliferation|down-regulation of acinous cell proliferation|downregulation of acinar cell proliferation|downregulation of acinic cell proliferation|downregulation of acinous cell proliferation|inhibition of acinar cell proliferation|inhibition of acinic cell proliferation|inhibition of acinous cell proliferation|negative regulation of acinic cell proliferation|negative regulation of acinous cell proliferation http://purl.obolibrary.org/obo/GO_1904698 GO:1904697 biolink:BiologicalProcess regulation of acinar cell proliferation Any process that modulates the frequency, rate or extent of acinar cell proliferation. go.json regulation of acinic cell proliferation|regulation of acinous cell proliferation http://purl.obolibrary.org/obo/GO_1904697 GO:1904696 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904696 GO:0003939 biolink:MolecularActivity L-iditol 2-dehydrogenase activity Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. EC:1.1.1.14|MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN|RHEA:10160|Reactome:R-HSA-5652195 go.json L-iditol (sorbitol) dehydrogenase activity|L-iditol:NAD oxidoreductase activity|L-iditol:NAD+ 5-oxidoreductase activity|NAD+-dependent sorbitol dehydrogenase activity|NAD-dependent sorbitol dehydrogenase activity|NAD-sorbitol dehydrogenase|glucitol dehydrogenase activity|polyol dehydrogenase activity|sorbitol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003939 GO:0003938 biolink:MolecularActivity IMP dehydrogenase activity Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. EC:1.1.1.205|MetaCyc:IMP-DEHYDROG-RXN|RHEA:11708|Reactome:R-HSA-73794|Reactome:R-HSA-9748945 go.json IMP oxidoreductase activity|IMP:NAD+ oxidoreductase activity|inosinate dehydrogenase activity|inosine 5'-monophosphate dehydrogenase activity|inosine monophosphate dehydrogenase activity|inosine monophosphate oxidoreductase activity|inosine-5'-phosphate dehydrogenase activity|inosinic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003938 GO:0003935 biolink:MolecularActivity GTP cyclohydrolase II activity Catalysis of the reaction: GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H+. EC:3.5.4.25|KEGG_REACTION:R00425|MetaCyc:GTP-CYCLOHYDRO-II-RXN|RHEA:23704 go.json GTP 7,8-8,9-dihydrolase (diphosphate-forming)|GTP-8-formylhydrolase activity|guanosine triphosphate cyclohydrolase II http://purl.obolibrary.org/obo/GO_0003935 GO:0003934 biolink:MolecularActivity GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. EC:3.5.4.16|KEGG_REACTION:R00424|MetaCyc:GTP-CYCLOHYDRO-I-RXN|RHEA:17473|Reactome:R-HSA-1474146 go.json GTP 7,8-8,9-dihydrolase activity|GTP 8-formylhydrolase activity|dihydroneopterin triphosphate synthase activity|guanosine triphosphate 8-deformylase activity|guanosine triphosphate cyclohydrolase activity http://purl.obolibrary.org/obo/GO_0003934 GO:0003937 biolink:MolecularActivity IMP cyclohydrolase activity Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. EC:3.5.4.10|MetaCyc:IMPCYCLOHYDROLASE-RXN|RHEA:18445|Reactome:R-HSA-73797 go.json IMP 1,2-hydrolase (decyclizing)|IMP synthetase activity|inosinate cyclohydrolase activity|inosinicase activity http://purl.obolibrary.org/obo/GO_0003937 GO:0003936 biolink:MolecularActivity obsolete hydrogen-transporting two-sector ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). go.json hydrogen-transporting two-sector ATPase activity|proton-transporting two-sector ATPase activity True http://purl.obolibrary.org/obo/GO_0003936 GO:0003942 biolink:MolecularActivity N-acetyl-gamma-glutamyl-phosphate reductase activity Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. EC:1.2.1.38|MetaCyc:N-ACETYLGLUTPREDUCT-RXN|RHEA:21588 go.json N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)|N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)|N-acetyl-glutamate semialdehyde dehydrogenase activity|N-acetylglutamate 5-semialdehyde dehydrogenase activity|N-acetylglutamic gamma-semialdehyde dehydrogenase activity|NAGSA dehydrogenase activity|reductase, acetyl-gamma-glutamyl phosphate http://purl.obolibrary.org/obo/GO_0003942 GO:0003941 biolink:MolecularActivity L-serine ammonia-lyase activity Catalysis of the reaction: L-serine = pyruvate + NH3. EC:4.3.1.17|MetaCyc:4.3.1.17-RXN|RHEA:19169 go.json L-hydroxyaminoacid dehydratase activity|L-serine ammonia-lyase (pyruvate-forming) activity|L-serine deaminase activity|L-serine dehydratase activity|L-serine dehydration activity|L-serine hydro-lyase (deaminating) activity|serine deaminase activity http://purl.obolibrary.org/obo/GO_0003941 GO:0003944 biolink:MolecularActivity N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. EC:3.1.4.45|MetaCyc:3.1.4.45-RXN|RHEA:24372 go.json 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity|alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity|alpha-N-acetylglucosaminyl phosphodiesterase activity|glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity|lysosomal alpha-N-acetylglucosaminidase activity|phosphodiester glycosidase activity http://purl.obolibrary.org/obo/GO_0003944 GO:0003943 biolink:MolecularActivity N-acetylgalactosamine-4-sulfatase activity Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. EC:3.1.6.12|MetaCyc:3.1.6.12-RXN|Reactome:R-HSA-1606789|Reactome:R-HSA-1793207|Reactome:R-HSA-2282889|Reactome:R-HSA-9036065|Wikipedia:Arylsulfatase_B go.json N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity|N-acetylgalactosamine 4-sulfate sulfohydrolase activity|N-acetylgalactosamine-4-sulphatase activity|acetylgalactosamine 4-sulfatase activity|arylsulfatase B|chondroitinsulfatase http://purl.obolibrary.org/obo/GO_0003943 GO:0003940 biolink:MolecularActivity L-iduronidase activity Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. EC:3.2.1.76|MetaCyc:3.2.1.76-RXN|Reactome:R-HSA-1678716|Reactome:R-HSA-1793186|Reactome:R-HSA-2090037|Reactome:R-HSA-2206299|Reactome:R-HSA-9036037|Reactome:R-HSA-9036041 go.json alpha-L-iduronidase activity|glycosaminoglycan alpha-L-iduronohydrolase activity http://purl.obolibrary.org/obo/GO_0003940 GO:0003949 biolink:MolecularActivity 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. EC:5.3.1.16|KEGG_REACTION:R04640|MetaCyc:PRIBFAICARPISOM-RXN|RHEA:15469 go.json 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity|1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity|N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity|N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity|phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity|phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity http://purl.obolibrary.org/obo/GO_0003949 GO:0003946 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003946 GO:0003945 biolink:MolecularActivity N-acetyllactosamine synthase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. EC:2.4.1.90|MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN|RHEA:17745 go.json Gal-T|N-acetylglucosamine (beta-1,4)galactosyltransferase activity|N-acetylglucosamine beta-(1,4)-galactosyltransferase activity|N-acetyllactosamine synthetase activity|NAL synthetase activity|UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity|UDP-beta-1,4-galactosyltransferase activity|UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity|UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity|UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity|UDP-galactose-N-acetylglucosamine galactosyltransferase activity|UDP-galactose-acetylglucosamine galactosyltransferase activity|UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity|UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity|UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity|UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity|UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity|acetyllactosamine synthetase activity|beta-(1,4)-galactosyltransferase activity|beta-1,4-GalT|beta-1,4-galactosyltransferase activity|beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity|lactosamine synthase activity|lactosamine synthetase activity|lactose synthetase A protein|uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0003945 GO:0003948 biolink:MolecularActivity N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+. EC:3.5.1.26|KEGG_REACTION:R03421|MetaCyc:3.5.1.26-RXN|RHEA:11544 go.json 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity|N-aspartyl-beta-glucosaminidase activity|N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity|aspartylglucosaminidase activity|aspartylglucosylaminase activity|aspartylglucosylamine deaspartylase activity|aspartylglucosylaminidase activity|aspartylglycosylamine amidohydrolase activity|beta-aspartylglucosylamine amidohydrolase activity|glucosylamidase activity|glycosylasparaginase activity http://purl.obolibrary.org/obo/GO_0003948 GO:0003947 biolink:MolecularActivity (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide. EC:2.4.1.92|MetaCyc:2.4.1.92-RXN|RHEA:12588|Reactome:R-HSA-8856223 go.json GM2 synthase activity|GM2/GD2-synthase activity|GalNAc-T activity|UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity|UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity|asialo-GM2 synthase activity|beta-1,4N-aetylgalactosaminyltransferase activity|ganglioside GM2 synthase activity|ganglioside GM3 acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0003947 GO:0003911 biolink:MolecularActivity DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). EC:6.5.1.2|MetaCyc:DNA-LIGASE-NAD+-RXN go.json DNA joinase activity|DNA ligase (NAD)|DNA repair enzyme activity|DNA-joining enzyme|deoxyribonucleate ligase|deoxyribonucleic acid joinase|deoxyribonucleic acid ligase|deoxyribonucleic joinase|deoxyribonucleic ligase|deoxyribonucleic repair enzyme|deoxyribonucleic-joining enzyme|poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)|polydeoxyribonucleotide synthase (NAD(+)) activity|polydeoxyribonucleotide synthase (NAD)|polydeoxyribonucleotide synthase (NAD+) activity|polynucleotide ligase|polynucleotide ligase (NAD(+)) activity|polynucleotide ligase (NAD)|polynucleotide ligase (NAD+) activity|polynucleotide ligase (nicotinamide adenine dinucleotide)|polynucleotide synthetase (nicotinamide adenine dinucleotide)|polynucleotide synthetase activity http://purl.obolibrary.org/obo/GO_0003911 GO:0003910 biolink:MolecularActivity DNA ligase (ATP) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). EC:6.5.1.1|MetaCyc:DNA-LIGASE-ATP-RXN go.json DNA joinase activity|DNA repair enzyme activity|DNA-joining enzyme|deoxyribonucleate ligase|deoxyribonucleic acid joinase|deoxyribonucleic acid ligase|deoxyribonucleic acid repair enzyme|deoxyribonucleic acid-joining enzyme|deoxyribonucleic joinase|deoxyribonucleic ligase|deoxyribonucleic repair enzyme|deoxyribonucleic-joining enzyme|poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)|polydeoxyribonucleotide synthase (ATP) activity|polynucleotide ligase|polynucleotide ligase (ATP) activity|sealase activity http://purl.obolibrary.org/obo/GO_0003910 GO:0003917 biolink:MolecularActivity DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. EC:5.6.2.1|MetaCyc:5.99.1.2-RXN go.json DNA topoisomerase I activity|deoxyribonucleate topoisomerase|nicking-closing enzyme activity|omega-protein activity|relaxing enzyme activity|swivelase activity|topoisomerase|type I DNA topoisomerase activity|type I topoisomerase activity|untwisting enzyme activity http://purl.obolibrary.org/obo/GO_0003917 GO:0003916 biolink:MolecularActivity DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0003916 GO:0003919 biolink:MolecularActivity FMN adenylyltransferase activity Catalysis of the reaction: ATP + FMN = diphosphate + FAD. EC:2.7.7.2|KEGG_REACTION:R00161|MetaCyc:FADSYN-RXN|RHEA:17237|Reactome:R-HSA-196929 go.json ATP:FMN adenylyltransferase activity|FAD diphosphorylase activity|FAD pyrophosphorylase activity|FAD synthetase activity|adenosine triphosphate-riboflavin mononucleotide transadenylase activity|adenosine triphosphate-riboflavine mononucleotide transadenylase activity|flavin adenine dinucleotide synthetase activity|riboflavin adenine dinucleotide pyrophosphorylase activity|riboflavin mononucleotide adenylyltransferase activity|riboflavine adenine dinucleotide adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0003919 GO:0003918 biolink:MolecularActivity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. EC:5.6.2.2|MetaCyc:5.99.1.3-RXN|Wikipedia:Type_II_topoisomerase go.json DNA topoisomerase (ATP-hydrolysing)|DNA topoisomerase II|DNA topoisomerase II activity|DNA topoisomerase IV activity|DNA topoisomerase type II activity|deoxyribonucleate topoisomerase|deoxyribonucleic topoisomerase activity|topoisomerase|topoisomerase II|type II DNA topoisomerase activity http://purl.obolibrary.org/obo/GO_0003918 GO:0003913 biolink:MolecularActivity DNA photolyase activity Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN go.json http://purl.obolibrary.org/obo/GO_0003913 GO:0003912 biolink:MolecularActivity DNA nucleotidylexotransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). EC:2.7.7.31|MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN go.json TdT|addase activity|deoxynucleotidyl terminal transferase activity|deoxyribonucleic acid nucleotidyltransferase activity|deoxyribonucleic nucleotidyltransferase activity|nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|terminal addition enzyme activity|terminal deoxynucleotide transferase activity|terminal deoxynucleotidyltransferase activity|terminal deoxyribonucleotidyltransferase activity|terminal transferase activity http://purl.obolibrary.org/obo/GO_0003912 GO:0003914 biolink:MolecularActivity DNA (6-4) photolyase activity Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. EC:4.1.99.13|MetaCyc:RXN-10771 go.json http://purl.obolibrary.org/obo/GO_0003914 GO:0003920 biolink:MolecularActivity GMP reductase activity Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH. EC:1.7.1.7|KEGG_REACTION:R01134|MetaCyc:GMP-REDUCT-RXN|RHEA:17185|Reactome:R-HSA-514604 go.json NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)|NADPH:GMP oxidoreductase (deaminating) activity|NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity|guanosine 5'-monophosphate oxidoreductase activity|guanosine 5'-monophosphate reductase activity|guanosine 5'-phosphate reductase activity|guanosine monophosphate reductase activity|guanylate reductase activity|inosine-5'-phosphate:NADP+ oxidoreductase (aminating) http://purl.obolibrary.org/obo/GO_0003920 GO:0003922 biolink:MolecularActivity GMP synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+. EC:6.3.5.2|MetaCyc:GMP-SYN-GLUT-RXN|RHEA:11680|Reactome:R-HSA-73792|Reactome:R-HSA-9748957|Wikipedia:GMP_synthase_(glutamine-hydrolysing) go.json GMP synthase (glutamine-hydrolysing)|GMP synthetase (glutamine-hydrolysing)|GMP synthetase (glutamine-hydrolyzing) activity|glutamine amidotransferase activity|guanosine 5'-monophosphate synthetase activity|guanosine monophosphate synthetase (glutamine-hydrolyzing)|guanylate synthetase (glutamine-hydrolyzing)|xanthosine 5'-phosphate amidotransferase activity|xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) http://purl.obolibrary.org/obo/GO_0003922 GO:0003921 biolink:MolecularActivity GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+. MetaCyc:GMP-SYN-NH3-RXN|RHEA:18301 go.json http://purl.obolibrary.org/obo/GO_0003921 GO:0003928 biolink:MolecularActivity obsolete RAB small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json RAB small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0003928 GO:0003927 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003927 GO:0003929 biolink:MolecularActivity obsolete RAN small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json RAN small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0003929 GO:0003924 biolink:MolecularActivity GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. MetaCyc:RXN0-5462|RHEA:19669|Reactome:R-HSA-1445143|Reactome:R-HSA-1458485|Reactome:R-HSA-156923|Reactome:R-HSA-164381|Reactome:R-HSA-165055|Reactome:R-HSA-167415|Reactome:R-HSA-170666|Reactome:R-HSA-170685|Reactome:R-HSA-170686|Reactome:R-HSA-177501|Reactome:R-HSA-203973|Reactome:R-HSA-2130641|Reactome:R-HSA-2130725|Reactome:R-HSA-2584246|Reactome:R-HSA-380979|Reactome:R-HSA-392133|Reactome:R-HSA-392212|Reactome:R-HSA-418574|Reactome:R-HSA-418582|Reactome:R-HSA-421835|Reactome:R-HSA-428941|Reactome:R-HSA-432707|Reactome:R-HSA-5333615|Reactome:R-HSA-5389839|Reactome:R-HSA-5389842|Reactome:R-HSA-5419273|Reactome:R-HSA-5419279|Reactome:R-HSA-555065|Reactome:R-HSA-5623513|Reactome:R-HSA-5638006|Reactome:R-HSA-5658231|Reactome:R-HSA-5665809|Reactome:R-HSA-5672017|Reactome:R-HSA-5694527|Reactome:R-HSA-6807877|Reactome:R-HSA-6814833|Reactome:R-HSA-8847534|Reactome:R-HSA-8847883|Reactome:R-HSA-8849082|Reactome:R-HSA-8854173|Reactome:R-HSA-8854255|Reactome:R-HSA-8854329|Reactome:R-HSA-8854604|Reactome:R-HSA-8854612|Reactome:R-HSA-8868661|Reactome:R-HSA-8981353|Reactome:R-HSA-8982020|Reactome:R-HSA-8982021|Reactome:R-HSA-8982025|Reactome:R-HSA-9018814|Reactome:R-HSA-9018826|Reactome:R-HSA-9640195|Reactome:R-HSA-9645598|Reactome:R-HSA-9649736|Reactome:R-HSA-983422 go.json ARF small monomeric GTPase activity|GTPase activity, coupled|RHEB small monomeric GTPase activity|Rab small monomeric GTPase activity|Ran small monomeric GTPase activity|Ras small monomeric GTPase activity|Rho small monomeric GTPase activity|Sar small monomeric GTPase activity|dynamin GTPase activity|heterotrimeric G-protein GTPase activity|heterotrimeric G-protein GTPase, alpha-subunit|heterotrimeric G-protein GTPase, beta-subunit|heterotrimeric G-protein GTPase, gamma-subunit|hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement|protein-synthesizing GTPase activity|protein-synthesizing GTPase activity, elongation|protein-synthesizing GTPase activity, initiation|protein-synthesizing GTPase activity, termination|signal-recognition-particle GTPase activity|small monomeric GTPase activity|tubulin GTPase activity http://purl.obolibrary.org/obo/GO_0003924 goslim_chembl|goslim_drosophila|goslim_generic|goslim_yeast|prokaryote_subset GO:0003923 biolink:MolecularActivity GPI-anchor transamidase activity Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. Reactome:R-HSA-162836 go.json http://purl.obolibrary.org/obo/GO_0003923 GO:0003926 biolink:MolecularActivity obsolete ARF small monomeric GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. go.json ARF small monomeric GTPase activity True http://purl.obolibrary.org/obo/GO_0003926 GO:0003925 biolink:MolecularActivity G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). go.json Ras superfamily protein|heterotrimeric G-protein GTPase activity|large G-protein GTPase activity|large G-protein activity|signaling G protein activity|small G-protein|small GTPase|small GTPase activity|small monomeric G protein activity|small monomeric GTPase activity http://purl.obolibrary.org/obo/GO_0003925 GO:0003900 biolink:MolecularActivity obsolete DNA-directed RNA polymerase I activity OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). go.json DNA-directed RNA polymerase I activity True http://purl.obolibrary.org/obo/GO_0003900 GO:0003909 biolink:MolecularActivity DNA ligase activity Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. Reactome:R-HSA-174456|Reactome:R-HSA-175258|Reactome:R-HSA-5358592|Reactome:R-HSA-5649734|Reactome:R-HSA-5651789|Reactome:R-HSA-5651805|Reactome:R-HSA-5687675|Reactome:R-HSA-5690997|Reactome:R-HSA-5693604|Reactome:R-HSA-6782227|Reactome:R-HSA-69173|Reactome:R-HSA-73931 go.json http://purl.obolibrary.org/obo/GO_0003909 GO:0003906 biolink:MolecularActivity DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). Reactome:R-HSA-110375|Reactome:R-HSA-5649711|Reactome:R-HSA-5649725 go.json AP deoxyendoribonuclease activity|UV endonuclease|abasic deoxyendoribonuclease activity|apurinic deoxyendoribonuclease activity|apurinic/apyrimidinic endodeoxyribonuclease activity|apyrimidinic deoxyendoribonuclease activity|deoxyribonuclease (apurinic or apyrimidinic) activity|endonuclease VIII activity http://purl.obolibrary.org/obo/GO_0003906 GO:0003905 biolink:MolecularActivity alkylbase DNA N-glycosylase activity Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. EC:3.2.2.21|MetaCyc:3.2.2.21-RXN go.json 3-methyladenine DNA glycosylase II|AlkA|DNA glycosidase II activity|DNA-3-methyladenine glycosidase II activity|DNA-3-methyladenine glycosylase II|alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)|alkylbase DNA glycosidase activity|deoxyribonucleate 3-methyladenine glycosidase II http://purl.obolibrary.org/obo/GO_0003905 GO:0003908 biolink:MolecularActivity methylated-DNA-[protein]-cysteine S-methyltransferase activity Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. EC:2.1.1.63|MetaCyc:2.1.1.63-RXN|RHEA:24000|Reactome:R-HSA-73892 go.json 6-O-methylguanine-DNA methyltransferase activity|DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity|DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity|MGMT|O-6-methylguanine-DNA-alkyltransferase activity|O6-alkylguanine-DNA alkyltransferase|methylated-DNA-protein-cysteine S-methyltransferase activity http://purl.obolibrary.org/obo/GO_0003908 GO:0003907 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003907 GO:0003902 biolink:MolecularActivity obsolete DNA-directed RNA polymerase III activity OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). go.json DNA-directed RNA polymerase III activity True http://purl.obolibrary.org/obo/GO_0003902 GO:0003901 biolink:MolecularActivity obsolete DNA-directed RNA polymerase II activity OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). go.json DNA-directed RNA polymerase II activity True http://purl.obolibrary.org/obo/GO_0003901 GO:0003904 biolink:MolecularActivity deoxyribodipyrimidine photo-lyase activity Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. EC:4.1.99.3|MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN|RHEA:10672 go.json CPD photolyase activity|DNA cyclobutane dipyrimidine photolyase activity|DNA-photoreactivating enzyme|PRE|PhrB photolyase activity|deoxyribocyclobutadipyrimidine pyrimidine-lyase activity|deoxyribodipyrimidine photolyase activity|deoxyribonucleate pyrimidine dimer lyase (photosensitive)|deoxyribonucleic cyclobutane dipyrimidine photolyase activity|deoxyribonucleic photolyase activity|dipyrimidine photolyase (photosensitive)|photolyase activity|photoreactivating enzyme activity|phr A photolyase activity http://purl.obolibrary.org/obo/GO_0003904 GO:0052843 biolink:MolecularActivity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. MetaCyc:RXN-10977 go.json inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity|inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0052843 GO:0052842 biolink:MolecularActivity inositol diphosphate pentakisphosphate diphosphatase activity Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate. KEGG_REACTION:R05779|Reactome:R-HSA-1855198|Reactome:R-HSA-2023971 go.json http://purl.obolibrary.org/obo/GO_0052842 GO:0052841 biolink:MolecularActivity inositol bisdiphosphate tetrakisphosphate diphosphatase activity Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate. Reactome:R-HSA-1855165|Reactome:R-HSA-2023973 go.json http://purl.obolibrary.org/obo/GO_0052841 GO:0052840 biolink:MolecularActivity inositol diphosphate tetrakisphosphate diphosphatase activity Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate. MetaCyc:RXN-10963|Reactome:R-HSA-1855166 go.json http://purl.obolibrary.org/obo/GO_0052840 GO:0052847 biolink:MolecularActivity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+. MetaCyc:RXN-10975 go.json http://purl.obolibrary.org/obo/GO_0052847 GO:0052846 biolink:MolecularActivity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+. MetaCyc:RXN-10965 go.json inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity|inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0052846 GO:0052845 biolink:MolecularActivity inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+. KEGG_REACTION:R05779|MetaCyc:RXN-10964|RHEA:22384 go.json http://purl.obolibrary.org/obo/GO_0052845 GO:0052844 biolink:MolecularActivity inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. MetaCyc:RXN-10978 go.json http://purl.obolibrary.org/obo/GO_0052844 GO:0052849 biolink:MolecularActivity NADPH-dependent curcumin reductase activity Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+. EC:1.3.1.n3|MetaCyc:RXN0-6676 go.json http://purl.obolibrary.org/obo/GO_0052849 GO:0052848 biolink:MolecularActivity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+. MetaCyc:RXN-10976|RHEA:56312 go.json http://purl.obolibrary.org/obo/GO_0052848 GO:0052854 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052854 GO:0052853 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052853 GO:0052852 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052852 GO:0052851 biolink:MolecularActivity ferric-chelate reductase (NADPH) activity Catalysis of the reaction: 2 Fe3+-siderophore + NADP+ + H+ -> 2 Fe2+-siderophore + NADPH. EC:1.16.1.9|KEGG_REACTION:R09541|MetaCyc:RXN0-6555|RHEA:28795 go.json ferric chelate reductase activity|ferric reductase, NADPH-dependent activity|iron chelate reductase activity http://purl.obolibrary.org/obo/GO_0052851 GO:1904609 biolink:BiologicalProcess obsolete cellular response to monosodium L-glutamate OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904609 GO:0052858 biolink:MolecularActivity peptidyl-lysine acetyltransferase activity Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine. go.json acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity|acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity|peptidyl-lysine N(6)-acetyltransferase activity|peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|peptidyl-lysine N6-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0052858 GO:1904608 biolink:BiologicalProcess obsolete response to monosodium L-glutamate OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904608 GO:0052857 biolink:MolecularActivity NADPHX epimerase activity Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX. EC:5.1.99.6|RHEA:32227|Reactome:R-HSA-6806966 go.json http://purl.obolibrary.org/obo/GO_0052857 GO:1904606 biolink:BiologicalProcess fat cell apoptotic process Any apoptotic process in a fat cell. go.json adipocyte apoptosis|adipocyte apoptotic process|adipose cell apoptosis|adipose cell apoptotic process|fat cell apoptosis http://purl.obolibrary.org/obo/GO_1904606 GO:0052856 biolink:MolecularActivity NADHX epimerase activity Catalysis of the reaction: (R)-NADHX = (S)-NADHX. EC:5.1.99.6|RHEA:32215 go.json http://purl.obolibrary.org/obo/GO_0052856 GO:1904605 biolink:BiologicalProcess positive regulation of advanced glycation end-product receptor activity Any process that activates or increases the frequency, rate or extent of advanced glycation end-product receptor activity. go.json activation of AGE receptor activity|activation of RAGE activity|activation of advanced glycation end-product receptor activity|positive regulation of AGE receptor activity|positive regulation of RAGE activity|up regulation of AGE receptor activity|up regulation of RAGE activity|up regulation of advanced glycation end-product receptor activity|up-regulation of AGE receptor activity|up-regulation of RAGE activity|up-regulation of advanced glycation end-product receptor activity|upregulation of AGE receptor activity|upregulation of RAGE activity|upregulation of advanced glycation end-product receptor activity http://purl.obolibrary.org/obo/GO_1904605 gocheck_do_not_annotate GO:0052855 biolink:MolecularActivity ADP-dependent NAD(P)H-hydrate dehydratase activity Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H+ + NADH + phosphate. EC:4.2.1.136 go.json (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)|(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)|ADP-dependent H(4)NAD(P)OH dehydratase activity|ADP-dependent H4NAD(P)OH dehydratase activity|reduced nicotinamide adenine dinucleotide hydrate dehydratase activity http://purl.obolibrary.org/obo/GO_0052855 GO:1904604 biolink:BiologicalProcess negative regulation of advanced glycation end-product receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity. go.json down regulation of AGE receptor activity|down regulation of RAGE activity|down regulation of advanced glycation end-product receptor activity|down-regulation of AGE receptor activity|down-regulation of RAGE activity|down-regulation of advanced glycation end-product receptor activity|downregulation of AGE receptor activity|downregulation of RAGE activity|downregulation of advanced glycation end-product receptor activity|inhibition of AGE receptor activity|inhibition of RAGE activity|inhibition of advanced glycation end-product receptor activity|negative regulation of AGE receptor activity|negative regulation of RAGE activity http://purl.obolibrary.org/obo/GO_1904604 gocheck_do_not_annotate GO:1904603 biolink:BiologicalProcess regulation of advanced glycation end-product receptor activity Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity. go.json regulation of AGE receptor activity|regulation of RAGE activity http://purl.obolibrary.org/obo/GO_1904603 gocheck_do_not_annotate GO:1904602 biolink:CellularComponent serotonin-activated cation-selective channel complex A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist. go.json 5-HT-3 receptor complex|5-HT3 receptor complex|5-hydroxytryptamine receptor 3 complex|5HT3 receptor complex|serotonin receptor complex http://purl.obolibrary.org/obo/GO_1904602 GO:1904601 biolink:BiologicalProcess protein transport to mating projection actin fusion focus A process in which a protein is transported to a location within an actin fusion focus. go.json protein localisation in actin fusion focus|protein localisation to actin fusion focus|protein localization in actin fusion focus http://purl.obolibrary.org/obo/GO_1904601 GO:0052859 biolink:MolecularActivity glucan endo-1,4-beta-glucosidase activity Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans. EC:3.2.1.75 go.json 1,4-beta-D-glucan glucanohydrolase activity|beta-1,4-glucan 4-glucanohydrolase activity|beta-1,4-glucan hydrolase activity|beta-1,4-glucanase activity|beta-1->4-glucan hydrolase activity|endo-(1,4)-beta-D-glucanase activity|endo-(1->4)-beta-D-glucanase activity|endo-1,4-beta-D-glucanase activity|endo-1,4-beta-glucanase activity|endo-beta-1,4-glucanase activity http://purl.obolibrary.org/obo/GO_0052859 GO:1904600 biolink:BiologicalProcess mating projection actin fusion focus assembly The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus. go.json actin fusion focus assembly|actin fusion focus formation http://purl.obolibrary.org/obo/GO_1904600 GO:0052850 biolink:MolecularActivity NADPH-dependent dihydrocurcumin reductase activity Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+. MetaCyc:RXN0-6677 go.json dihydrocurcumin reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0052850 GO:0052865 biolink:BiologicalProcess 1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. go.json (2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate anabolism|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthesis|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthetic process|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate formation|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate synthesis|1-deoxy-D-xylulose 5-phosphate anabolism|1-deoxy-D-xylulose 5-phosphate biosynthesis|1-deoxy-D-xylulose 5-phosphate formation|1-deoxy-D-xylulose 5-phosphate synthesis http://purl.obolibrary.org/obo/GO_0052865 GO:0003898 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003898 GO:0003897 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003897 GO:0052864 biolink:BiologicalProcess 1-deoxy-D-xylulose 5-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. go.json (2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate breakdown|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolic process|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolism|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate degradation|1-deoxy-D-xylulose 5-phosphate breakdown|1-deoxy-D-xylulose 5-phosphate catabolism|1-deoxy-D-xylulose 5-phosphate degradation http://purl.obolibrary.org/obo/GO_0052864 GO:0052863 biolink:BiologicalProcess 1-deoxy-D-xylulose 5-phosphate metabolic process The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. go.json (2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolic process|(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolism|1-deoxy-D-xylulose 5-phosphate metabolism http://purl.obolibrary.org/obo/GO_0052863 GO:0052862 biolink:MolecularActivity glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. EC:3.2.1.6|MetaCyc:3.2.1.6-RXN go.json 1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity|laminaranase activity|laminarinase activity http://purl.obolibrary.org/obo/GO_0052862 GO:0003899 biolink:MolecularActivity DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. EC:2.7.7.6|MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN|Reactome:R-HSA-111264|Reactome:R-HSA-167113|Reactome:R-HSA-167115|Reactome:R-HSA-167117|Reactome:R-HSA-167121|Reactome:R-HSA-167136|Reactome:R-HSA-174425|Reactome:R-HSA-203901|Reactome:R-HSA-427366|Reactome:R-HSA-5601926|Reactome:R-HSA-6781824|Reactome:R-HSA-68913|Reactome:R-HSA-74986|Reactome:R-HSA-75850|Reactome:R-HSA-75869|Reactome:R-HSA-75873|Reactome:R-HSA-76576|Reactome:R-HSA-9670149|Reactome:R-HSA-9697084|Reactome:R-HSA-9697085 go.json C RNA formation factors|C ribonucleic acid formation factors|DNA-dependent RNA nucleotidyltransferase activity|DNA-dependent RNA polymerase activity|DNA-dependent ribonucleate nucleotidyltransferase activity|DNA-directed RNA polymerase I activity|DNA-directed RNA polymerase II activity|DNA-directed RNA polymerase III activity|DNA-directed RNA polymerase activity|RNA nucleotidyltransferase (DNA-directed) activity|RNA polymerase I activity|RNA polymerase II activity|RNA polymerase III activity|deoxyribonucleic acid-dependent ribonucleic acid polymerase activity|nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity|transcriptase http://purl.obolibrary.org/obo/GO_0003899 GO:0003894 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003894 GO:0052869 biolink:MolecularActivity arachidonic acid omega-hydroxylase activity Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid. EC:1.14.15.3|KEGG_REACTION:R07041 go.json arachidonic acid hydroxylase activity|arachidonic acid:oxygen 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052869 GO:1904619 biolink:BiologicalProcess response to dimethyl sulfoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus. go.json response to DMSO http://purl.obolibrary.org/obo/GO_1904619 GO:1904618 biolink:BiologicalProcess positive regulation of actin binding Any process that activates or increases the frequency, rate or extent of actin binding. go.json activation of actin binding|activation of membrane associated actin binding|positive regulation of membrane associated actin binding|up regulation of actin binding|up regulation of membrane associated actin binding|up-regulation of actin binding|up-regulation of membrane associated actin binding|upregulation of actin binding|upregulation of membrane associated actin binding http://purl.obolibrary.org/obo/GO_1904618 gocheck_do_not_annotate GO:0052868 biolink:MolecularActivity protein-lysine lysyltransferase activity Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine. go.json http://purl.obolibrary.org/obo/GO_0052868 GO:0003893 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003893 GO:0052867 biolink:MolecularActivity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate. go.json PtdIns(1,4,5)P(3) phosphatase activity|PtdIns(1,4,5)P3 phosphatase activity|phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity|phosphatidylinositol 1,4,5-trisphosphate phosphatase activity|phosphatidylinositol-trisphosphatase activity|triphosphoinositide phosphatase activity|triphosphoinositide phosphomonoesterase activity http://purl.obolibrary.org/obo/GO_0052867 GO:0003896 biolink:MolecularActivity DNA primase activity Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. EC:2.7.7.101 go.json http://purl.obolibrary.org/obo/GO_0003896 GO:1904617 biolink:BiologicalProcess negative regulation of actin binding Any process that stops, prevents or reduces the frequency, rate or extent of actin binding. go.json down regulation of actin binding|down regulation of membrane associated actin binding|down-regulation of actin binding|down-regulation of membrane associated actin binding|downregulation of actin binding|downregulation of membrane associated actin binding|inhibition of actin binding|inhibition of membrane associated actin binding|negative regulation of membrane associated actin binding http://purl.obolibrary.org/obo/GO_1904617 gocheck_do_not_annotate GO:0052866 biolink:MolecularActivity phosphatidylinositol phosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. go.json phosphoinositide phosphatase activity http://purl.obolibrary.org/obo/GO_0052866 GO:0003895 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003895 GO:1904616 biolink:BiologicalProcess regulation of actin binding Any process that modulates the frequency, rate or extent of actin binding. go.json regulation of membrane associated actin binding http://purl.obolibrary.org/obo/GO_1904616 gocheck_do_not_annotate GO:1904615 biolink:BiologicalProcess cellular response to biphenyl Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus. go.json http://purl.obolibrary.org/obo/GO_1904615 GO:0003890 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003890 GO:1904614 biolink:BiologicalProcess response to biphenyl Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus. go.json http://purl.obolibrary.org/obo/GO_1904614 GO:1904613 biolink:BiologicalProcess cellular response to 2,3,7,8-tetrachlorodibenzodioxine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. go.json cellular response to TCDD|cellular response to dioxin http://purl.obolibrary.org/obo/GO_1904613 GO:0003892 biolink:MolecularActivity obsolete proliferating cell nuclear antigen OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair. go.json PCNA|proliferating cell nuclear antigen True http://purl.obolibrary.org/obo/GO_0003892 GO:1904612 biolink:BiologicalProcess response to 2,3,7,8-tetrachlorodibenzodioxine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. go.json response to TCDD|response to dioxin http://purl.obolibrary.org/obo/GO_1904612 GO:0003891 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003891 GO:1904611 biolink:BiologicalProcess cellular response to 3,3',4,4',5-pentachlorobiphenyl Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus. go.json cellular response to PCB 126 http://purl.obolibrary.org/obo/GO_1904611 GO:1904610 biolink:BiologicalProcess response to 3,3',4,4',5-pentachlorobiphenyl Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus. go.json response to PCB 126 http://purl.obolibrary.org/obo/GO_1904610 GO:0052861 biolink:MolecularActivity glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. EC:3.2.1.6|MetaCyc:3.2.1.6-RXN go.json 1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity|laminaranase activity|laminarinase activity http://purl.obolibrary.org/obo/GO_0052861 GO:0052860 biolink:MolecularActivity 2'-deoxymugineic-acid 3-dioxygenase activity Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2. EC:1.14.11.25|KEGG_REACTION:R07187|MetaCyc:RXN-7983|RHEA:20065 go.json 2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0052860 GO:0052876 biolink:MolecularActivity methylamine dehydrogenase (amicyanin) activity Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]. EC:1.4.9.1|KEGG_REACTION:R00606|RHEA:30207|UM-BBD_reactionID:r0075 go.json MADH activity|amine dehydrogenase|methylamine dehydrogenase activity|methylamine:amicyanin oxidoreductase (deaminating) activity|primary-amine dehydrogenase http://purl.obolibrary.org/obo/GO_0052876 GO:0052875 biolink:MolecularActivity riboflavin reductase (NAD(P)H) activity Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH. EC:1.5.1.41|KEGG_REACTION:R09750|MetaCyc:RXN-12445|RHEA:31455 go.json NAD(P)H-FMN reductase activity|NAD(P)H-dependent FMN reductase activity|NAD(P)H2 dehydrogenase (FMN) activity|NAD(P)H2:FMN oxidoreductase activity|NAD(P)H:FMN oxidoreductase activity|NAD(P)H:riboflavin oxidoreductase activity|flavin mononucleotide reductase activity|flavine mononucleotide reductase activity|riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity|riboflavin mononucleotide reductase activity|riboflavin reductase (NADH) activity|riboflavin reductase (NADPH) activity|riboflavine mononucleotide reductase activity http://purl.obolibrary.org/obo/GO_0052875 GO:0052874 biolink:MolecularActivity FMN reductase (NADH) activity Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+. EC:1.5.1.42|KEGG_REACTION:R05705|RHEA:21620 go.json NADH dehydrogenase (FMN) activity|NADH-FMN reductase activity|NADH-dependent FMN reductase activity http://purl.obolibrary.org/obo/GO_0052874 GO:0052873 biolink:MolecularActivity FMN reductase (NADPH) activity Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. EC:1.5.1.38|KEGG_REACTION:R05706|RHEA:21624|Reactome:R-HSA-1222399 go.json NADPH dehydrogenase (FMN) activity http://purl.obolibrary.org/obo/GO_0052873 GO:0052879 biolink:MolecularActivity 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate. EC:5.4.4.6|KEGG_REACTION:R07062|MetaCyc:RXN-12758|RHEA:25399 go.json (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity|8-hydroperoxide isomerase activity|linoleate diol synthase activity http://purl.obolibrary.org/obo/GO_0052879 GO:1904629 biolink:BiologicalProcess response to diterpene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus. go.json http://purl.obolibrary.org/obo/GO_1904629 GO:0052878 biolink:MolecularActivity linoleate 8R-lipoxygenase activity Catalysis of the reaction: O2 + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate. EC:1.13.11.60|KEGG_REACTION:R07061|MetaCyc:RXN-12756|RHEA:25395 go.json 5,8-LDS (bifunctional enzyme) activity|5,8-linoleate diol synthase (bifunctional enzyme) activity|7,8-LDS (bifunctional enzyme) activity|7,8-linoleate diol synthase (bifunctional enzyme) activity|linoleate diol synthase activity http://purl.obolibrary.org/obo/GO_0052878 GO:1904628 biolink:BiologicalProcess cellular response to phorbol 13-acetate 12-myristate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. go.json cellular response to TPA|cellular response to phorbol 12-tetradecanoate 13-acetate|cellular response to response to PMA|cellular response to tetradecanoylphorbol acetate http://purl.obolibrary.org/obo/GO_1904628 GO:1904627 biolink:BiologicalProcess response to phorbol 13-acetate 12-myristate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. go.json response to PMA|response to TPA|response to phorbol 12-tetradecanoate 13-acetate|response to tetradecanoylphorbol acetate http://purl.obolibrary.org/obo/GO_1904627 GO:0052877 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor. EC:1.4.9.- go.json http://purl.obolibrary.org/obo/GO_0052877 GO:1904626 biolink:BiologicalProcess positive regulation of glycine secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission. go.json activation of glycine secretion, neurotransmission|up regulation of glycine secretion, neurotransmission|up-regulation of glycine secretion, neurotransmission|upregulation of glycine secretion, neurotransmission http://purl.obolibrary.org/obo/GO_1904626 GO:1904625 biolink:BiologicalProcess negative regulation of glycine secretion, neurotransmission Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission. go.json down regulation of glycine secretion, neurotransmission|down-regulation of glycine secretion, neurotransmission|downregulation of glycine secretion, neurotransmission|inhibition of glycine secretion, neurotransmission http://purl.obolibrary.org/obo/GO_1904625 GO:1904624 biolink:BiologicalProcess regulation of glycine secretion, neurotransmission Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission. go.json http://purl.obolibrary.org/obo/GO_1904624 GO:1904623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904623 GO:1904622 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904622 GO:1904621 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904621 GO:1904620 biolink:BiologicalProcess cellular response to dimethyl sulfoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus. go.json cellular response to DMSO http://purl.obolibrary.org/obo/GO_1904620 GO:0052872 biolink:MolecularActivity tocotrienol omega-hydroxylase activity Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O . EC:1.14.13.- go.json tocotrienol 13-hydroxylase activity http://purl.obolibrary.org/obo/GO_0052872 GO:0052871 biolink:MolecularActivity alpha-tocopherol omega-hydroxylase activity Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O . MetaCyc:RXN-11003 go.json alpha-tocopherol 13-hydroxylase activity http://purl.obolibrary.org/obo/GO_0052871 GO:0052870 biolink:MolecularActivity tocopherol omega-hydroxylase activity Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O . go.json tocopherol 13-hydroxylase activity http://purl.obolibrary.org/obo/GO_0052870 GO:0003876 biolink:MolecularActivity AMP deaminase activity Catalysis of the reaction: AMP + H2O = IMP + NH3. EC:3.5.4.6|MetaCyc:AMP-DEAMINASE-RXN|RHEA:14777|Reactome:R-HSA-76590 go.json 5-AMP deaminase activity|5-adenylate deaminase activity|5-adenylic acid deaminase activity|AMP aminase activity|AMP aminohydrolase activity|adenosine 5-monophosphate deaminase activity|adenosine 5-phosphate aminohydrolase activity|adenosine monophosphate deaminase activity|adenyl deaminase activity|adenylate aminohydrolase activity|adenylate deaminase activity|adenylate deaminase reaction|adenylate desaminase activity|adenylic acid deaminase activity|adenylic deaminase activity|myoadenylate deaminase activity http://purl.obolibrary.org/obo/GO_0003876 GO:0052887 biolink:MolecularActivity 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol. EC:1.3.5.6|KEGG_REACTION:R09658|MetaCyc:RXN-11357 go.json 9,9'-di-cis-zeta-carotene desaturase activity|ZDS activity|zeta-carotene desaturase activity http://purl.obolibrary.org/obo/GO_0052887 GO:0003875 biolink:MolecularActivity ADP-ribosylarginine hydrolase activity Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. EC:3.2.2.19|MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN|RHEA:20784 go.json ADP-ribose-L-arginine cleavage enzyme activity|ADP-ribose-L-arginine cleaving enzyme activity|ADPribosylarginine hydrolase activity|N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|protein ADP-ribosylarginine hydrolase activity|protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity http://purl.obolibrary.org/obo/GO_0003875 GO:0052886 biolink:MolecularActivity 9,9'-dicis-carotene:quinone oxidoreductase activity Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol. EC:1.3.5.6|KEGG_REACTION:R09656|MetaCyc:RXN-11356|RHEA:30959 go.json 9,9'-di-cis-zeta-carotene desaturase activity|ZDS activity|zeta-carotene desaturase activity http://purl.obolibrary.org/obo/GO_0052886 GO:0003878 biolink:MolecularActivity ATP citrate synthase activity Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA. EC:2.3.3.8|KEGG_REACTION:R00352|MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN|MetaCyc:PWY-5172|RHEA:21160|Reactome:R-HSA-75848 go.json ATP citrate (pro-S)-lyase activity|ATP-citrate (pro-S)-lyase activity|ATP-citrate (pro-S-)-lyase activity|ATP-citric lyase activity|ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity|ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)|acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]|acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity|acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)|adenosine triphosphate citrate lyase activity|citrate cleavage enzyme activity|citrate-ATP lyase activity|citric cleavage enzyme activity http://purl.obolibrary.org/obo/GO_0003878 GO:0052885 biolink:MolecularActivity all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid. EC:3.1.1.64|KEGG_REACTION:R08388|MetaCyc:RXN-12550|RHEA:31771 go.json all-trans-retinol isomerase:hydrolase activity|all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity|all-trans-retinylester 11-cis isomerohydrolase activity|retinoid isomerohydrolase activity|retinol isomerase activity http://purl.obolibrary.org/obo/GO_0052885 GO:0003877 biolink:MolecularActivity ATP adenylyltransferase activity Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. EC:2.7.7.53|MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN|RHEA:16577 go.json ADP:ATP adenylyltransferase activity|AP-4-A phosphorylase activity|adenine triphosphate adenylyltransferase activity|bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity|diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity|diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)|diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity|diadenosinetetraphosphate alpha-beta-phosphorylase activity|diadenosinetetraphosphate alphabeta-phosphorylase activity|dinucleoside oligophosphate alphabeta-phosphorylase activity http://purl.obolibrary.org/obo/GO_0003877 GO:0052884 biolink:MolecularActivity all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate. EC:3.1.1.64|RHEA:31775|Reactome:R-HSA-2453833 go.json all-trans-retinol isomerase:hydrolase activity|all-trans-retinyl-palmitate hydrolase activity|retinoid isomerohydrolase activity|retinol isomerase activity http://purl.obolibrary.org/obo/GO_0052884 GO:0003872 biolink:MolecularActivity 6-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. EC:2.7.1.11|MetaCyc:6PFRUCTPHOS-RXN|RHEA:16109|Reactome:R-HSA-70467 go.json 6-phosphofructokinase reduction|6-phosphofructose 1-kinase activity|ATP-dependent phosphofructokinase activity|ATP:D-fructose-6-phosphate 1-phosphotransferase activity|D-fructose-6-phosphate 1-phosphotransferase activity|PFK|fructose 6-phosphate kinase activity|fructose 6-phosphokinase activity|nucleotide triphosphate-dependent phosphofructokinase activity|phospho-1,6-fructokinase activity|phosphofructokinase (phosphorylating)|phosphofructokinase I activity|phosphohexokinase activity http://purl.obolibrary.org/obo/GO_0003872 GO:0003871 biolink:MolecularActivity 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. EC:2.1.1.14|KEGG_REACTION:R04405|MetaCyc:HOMOCYSMET-RXN|RHEA:21196 go.json 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity|MetE|cobalamin-independent methionine synthase activity|homocysteine methylase activity|methionine synthase (cobalamin-independent) activity|methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity|methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity|tetrahydropteroylglutamate-homocysteine transmethylase activity|tetrahydropteroyltriglutamate methyltransferase activity http://purl.obolibrary.org/obo/GO_0003871 GO:0052889 biolink:BiologicalProcess 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene. KEGG_REACTION:R07511|MetaCyc:RXN-12242 go.json 7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene|9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene http://purl.obolibrary.org/obo/GO_0052889 GO:1904639 biolink:BiologicalProcess cellular response to resveratrol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus. go.json http://purl.obolibrary.org/obo/GO_1904639 GO:0003874 biolink:MolecularActivity 6-pyruvoyltetrahydropterin synthase activity Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate. EC:4.2.3.12|KEGG_REACTION:R04286|MetaCyc:4.2.3.12-RXN|RHEA:22048|Reactome:R-HSA-1474184 go.json 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity|2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)|6-pyruvoyl tetrahydrobiopterin synthase activity|PTPS activity http://purl.obolibrary.org/obo/GO_0003874 GO:0052888 biolink:MolecularActivity obsolete dihydroorotate oxidase (fumarate) activity OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate. EC:1.3.98.1|KEGG_REACTION:R01867|MetaCyc:RXN-9929 go.json DHOD activity|DHOdase activity|DHodehase activity|dihydoorotic acid dehydrogenase activity|dihydroorotate dehydrogenase activity|dihydroorotate oxidase (fumarate) activity|dihydroorotate oxidase activity True http://purl.obolibrary.org/obo/GO_0052888 GO:1904638 biolink:BiologicalProcess response to resveratrol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus. go.json http://purl.obolibrary.org/obo/GO_1904638 GO:0003873 biolink:MolecularActivity 6-phosphofructo-2-kinase activity Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+. EC:2.7.1.105|KEGG_REACTION:R02732|MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN|RHEA:15653|Reactome:R-HSA-71802 go.json 6-phosphofructo-2-kinase (phosphorylating)|6-phosphofructose 2-kinase activity|ATP:D-fructose-6-phosphate 2-phosphotransferase activity|ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity|fructose 6-phosphate 2-kinase activity|phosphofructokinase 2 activity http://purl.obolibrary.org/obo/GO_0003873 GO:1904637 biolink:BiologicalProcess cellular response to ionomycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904637 GO:1904636 biolink:BiologicalProcess response to ionomycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904636 GO:1904635 biolink:BiologicalProcess positive regulation of podocyte apoptotic process Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process. go.json activation of glomerular podocyte apoptosis|activation of glomerular podocyte apoptotic process|activation of glomerular visceral epithelial cell apoptosis|activation of glomerular visceral epithelial cell apoptotic process|activation of podocyte apoptosis|activation of podocyte apoptotic process|positive regulation of glomerular podocyte apoptosis|positive regulation of glomerular podocyte apoptotic process|positive regulation of glomerular visceral epithelial cell apoptosis|positive regulation of glomerular visceral epithelial cell apoptotic process|positive regulation of podocyte apoptosis|up regulation of glomerular podocyte apoptosis|up regulation of glomerular podocyte apoptotic process|up regulation of glomerular visceral epithelial cell apoptosis|up regulation of glomerular visceral epithelial cell apoptotic process|up regulation of podocyte apoptosis|up regulation of podocyte apoptotic process|up-regulation of glomerular podocyte apoptosis|up-regulation of glomerular podocyte apoptotic process|up-regulation of glomerular visceral epithelial cell apoptosis|up-regulation of glomerular visceral epithelial cell apoptotic process|up-regulation of podocyte apoptosis|up-regulation of podocyte apoptotic process|upregulation of glomerular podocyte apoptosis|upregulation of glomerular podocyte apoptotic process|upregulation of glomerular visceral epithelial cell apoptosis|upregulation of glomerular visceral epithelial cell apoptotic process|upregulation of podocyte apoptosis|upregulation of podocyte apoptotic process http://purl.obolibrary.org/obo/GO_1904635 GO:0003870 biolink:MolecularActivity 5-aminolevulinate synthase activity Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA. EC:2.3.1.37|KEGG_REACTION:R00830|MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN|RHEA:12921|Reactome:R-HSA-189442 go.json 5-aminolevulinate synthetase activity|5-aminolevulinic acid synthase activity|5-aminolevulinic acid synthetase activity|ALA synthase activity|ALA synthetase activity|ALAS activity|alpha-aminolevulinic acid synthase activity|aminolevulinate synthase activity|aminolevulinate synthetase activity|aminolevulinic acid synthase activity|aminolevulinic acid synthetase activity|aminolevulinic synthetase activity|delta-ALA synthetase activity|delta-aminolevulinate synthase activity|delta-aminolevulinate synthetase activity|delta-aminolevulinic acid synthase activity|delta-aminolevulinic acid synthetase activity|delta-aminolevulinic synthetase activity|succinyl-CoA:glycine C-succinyltransferase (decarboxylating) http://purl.obolibrary.org/obo/GO_0003870 GO:1904634 biolink:BiologicalProcess negative regulation of podocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process. go.json down regulation of glomerular podocyte apoptosis|down regulation of glomerular podocyte apoptotic process|down regulation of glomerular visceral epithelial cell apoptosis|down regulation of glomerular visceral epithelial cell apoptotic process|down regulation of podocyte apoptosis|down regulation of podocyte apoptotic process|down-regulation of glomerular podocyte apoptosis|down-regulation of glomerular podocyte apoptotic process|down-regulation of glomerular visceral epithelial cell apoptosis|down-regulation of glomerular visceral epithelial cell apoptotic process|down-regulation of podocyte apoptosis|down-regulation of podocyte apoptotic process|downregulation of glomerular podocyte apoptosis|downregulation of glomerular podocyte apoptotic process|downregulation of glomerular visceral epithelial cell apoptosis|downregulation of glomerular visceral epithelial cell apoptotic process|downregulation of podocyte apoptosis|downregulation of podocyte apoptotic process|inhibition of glomerular podocyte apoptosis|inhibition of glomerular podocyte apoptotic process|inhibition of glomerular visceral epithelial cell apoptosis|inhibition of glomerular visceral epithelial cell apoptotic process|inhibition of podocyte apoptosis|inhibition of podocyte apoptotic process|negative regulation of glomerular podocyte apoptosis|negative regulation of glomerular podocyte apoptotic process|negative regulation of glomerular visceral epithelial cell apoptosis|negative regulation of glomerular visceral epithelial cell apoptotic process|negative regulation of podocyte apoptosis http://purl.obolibrary.org/obo/GO_1904634 GO:1904633 biolink:BiologicalProcess regulation of podocyte apoptotic process Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process. go.json regulation of glomerular podocyte apoptosis|regulation of glomerular podocyte apoptotic process|regulation of glomerular visceral epithelial cell apoptosis|regulation of glomerular visceral epithelial cell apoptotic process|regulation of podocyte apoptosis http://purl.obolibrary.org/obo/GO_1904633 GO:1904632 biolink:BiologicalProcess cellular response to glucoside Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus. go.json cellular response to glucosides http://purl.obolibrary.org/obo/GO_1904632 GO:0062211 biolink:BiologicalProcess root regeneration The the regeneration process by which a damaged or lost root regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to form a new root meristem and subsequently new root. go.json http://purl.obolibrary.org/obo/GO_0062211 GO:1904631 biolink:BiologicalProcess response to glucoside Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus. go.json response to glucosides http://purl.obolibrary.org/obo/GO_1904631 GO:0062210 biolink:BiologicalProcess shoot regeneration The regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot. go.json shoot system regeneration http://purl.obolibrary.org/obo/GO_0062210 GO:1904630 biolink:BiologicalProcess cellular response to diterpene Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus. go.json http://purl.obolibrary.org/obo/GO_1904630 GO:0062213 biolink:MolecularActivity peroxynitrite isomerase activity Catalysis of the reaction: peroxynitrite = nitrate. RHEA:63116 go.json http://purl.obolibrary.org/obo/GO_0062213 GO:1904640 biolink:BiologicalProcess response to methionine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904640 GO:0062212 biolink:BiologicalProcess regulation of mitotic DNA replication initiation from early origin Any process that modulates the frequency, rate or extent of firing from an early origin of replication involved in mitotic DNA replication. go.json regulation of early replication origin firing http://purl.obolibrary.org/obo/GO_0062212 GO:0052883 biolink:MolecularActivity tyrosine ammonia-lyase activity Catalysis of the reaction: L-tyrosine = NH4 + trans-4-coumarate. EC:4.3.1.23|EC:4.3.1.25|RHEA:24906 go.json L-tyrosine ammonia-lyase activity|TAL activity|tyrase activity http://purl.obolibrary.org/obo/GO_0052883 GO:0003879 biolink:MolecularActivity ATP phosphoribosyltransferase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. EC:2.4.2.17|MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN|RHEA:18473 go.json 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity|adenosine triphosphate phosphoribosyltransferase activity|phosphoribosyl ATP synthetase activity|phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity|phosphoribosyl-ATP diphosphorylase activity|phosphoribosyl-ATP pyrophosphorylase activity|phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity|phosphoribosyladenosine triphosphate pyrophosphorylase activity|phosphoribosyladenosine triphosphate synthetase activity|phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity http://purl.obolibrary.org/obo/GO_0003879 GO:0052882 biolink:MolecularActivity oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein. EC:1.20.9.- go.json http://purl.obolibrary.org/obo/GO_0052882 GO:0052881 biolink:MolecularActivity 4-hydroxyphenylacetate 3-monooxygenase activity Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O. EC:1.14.14.9|MetaCyc:RXN-8505|RHEA:30595|UM-BBD_reactionID:r0301 go.json 4 HPA 3-hydroxylase activity|4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity|4-hydroxyphenylacetic acid-3-hydroxylase activity|p-hydroxyphenylacetate 3-hydroxylase (FAD) activity|p-hydroxyphenylacetate 3-hydroxylase activity|p-hydroxyphenylacetate hydroxylase (FAD) activity|p-hydroxyphenylacetate hydroxylase activity http://purl.obolibrary.org/obo/GO_0052881 GO:0052880 biolink:MolecularActivity oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein. EC:1.10.9.- go.json http://purl.obolibrary.org/obo/GO_0052880 GO:0003887 biolink:MolecularActivity DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. EC:2.7.7.7|MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN|Reactome:R-HSA-110311|Reactome:R-HSA-110317|Reactome:R-HSA-110319|Reactome:R-HSA-110368|Reactome:R-HSA-111253|Reactome:R-HSA-164505|Reactome:R-HSA-164513|Reactome:R-HSA-174427|Reactome:R-HSA-174444|Reactome:R-HSA-5358579|Reactome:R-HSA-5649723|Reactome:R-HSA-5649883|Reactome:R-HSA-5653840|Reactome:R-HSA-5655892|Reactome:R-HSA-5655965|Reactome:R-HSA-5656148|Reactome:R-HSA-5656158|Reactome:R-HSA-5687360|Reactome:R-HSA-5687640|Reactome:R-HSA-5691001|Reactome:R-HSA-5693593|Reactome:R-HSA-6782208|Reactome:R-HSA-6786166|Reactome:R-HSA-68950|Reactome:R-HSA-69116|Reactome:R-HSA-73932|Reactome:R-HSA-9710480 go.json DNA duplicase activity|DNA nucleotidyltransferase (DNA-directed) activity|DNA polymerase I|DNA polymerase II|DNA polymerase III|DNA polymerase V activity|DNA polymerase alpha|DNA polymerase beta|DNA polymerase gamma|DNA replicase activity|DNA-dependent DNA polymerase activity|Klenow fragment|Taq DNA polymerase|Taq Pol I|Tca DNA polymerase|alpha DNA polymerase activity|beta DNA polymerase activity|delta DNA polymerase activity|deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|deoxyribonucleic acid duplicase activity|deoxyribonucleic duplicase activity|deoxyribonucleic polymerase I|duplicase|epsilon DNA polymerase activity|eta DNA polymerase activity|gamma DNA-directed DNA polymerase activity|iota DNA polymerase activity|kappa DNA polymerase activity|lambda DNA polymerase activity|mu DNA polymerase activity|nu DNA polymerase activity|sequenase|sigma DNA polymerase activity|theta DNA polymerase activity|zeta DNA polymerase activity http://purl.obolibrary.org/obo/GO_0003887 GO:0052898 biolink:MolecularActivity obsolete N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity OBSOLETE. Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2. go.json True http://purl.obolibrary.org/obo/GO_0052898 GO:0003886 biolink:MolecularActivity DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. EC:2.1.1.37|MetaCyc:DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN|RHEA:13681 go.json DNA 5-cytosine methylase activity|DNA cytosine C(5) methylase activity|DNA cytosine C5 methylase activity|DNA cytosine methylase activity|DNA-cytosine 5-methylase activity|DNA-cytosine methyltransferase activity|S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity|cytosine 5-methyltransferase activity|cytosine DNA methylase activity|cytosine DNA methyltransferase activity|cytosine-specific DNA methyltransferase activity|deoxyribonucleic (cytosine-5-)-methyltransferase activity|deoxyribonucleic acid (cytosine-5-)-methyltransferase activity|deoxyribonucleic methylase activity|methylphosphotriester-DNA methyltransferase activity|modification methylase activity|restriction-modification system activity|site-specific DNA-methyltransferase (cytosine-specific) activity|type II DNA methylase activity http://purl.obolibrary.org/obo/GO_0003886 GO:0052897 biolink:MolecularActivity N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2. EC:1.5.3.15|KEGG_REACTION:R09075|MetaCyc:RXN-10463|RHEA:25972 go.json N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity http://purl.obolibrary.org/obo/GO_0052897 GO:0052896 biolink:MolecularActivity spermidine oxidase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H2O + O2 + spermidine = 1,3-diaminopropane + 4-aminobutanal + H2O2. EC:1.5.3.14|KEGG_REACTION:R01914|MetaCyc:RXN-10747|RHEA:25820 go.json polyamine oxidase (propane-1,3-diamine-forming) activity|spermidine:(acceptor) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052896 GO:0003889 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003889 GO:0003888 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003888 GO:0052895 biolink:MolecularActivity N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. EC:1.5.3.16|MetaCyc:POLYAMINE-OXIDASE-RXN|RHEA:16133 go.json N1-acetylspermine oxidase activity http://purl.obolibrary.org/obo/GO_0052895 GO:0003883 biolink:MolecularActivity CTP synthase activity Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. EC:6.3.4.2|MetaCyc:CTPSYN-RXN|RHEA:26426|Reactome:R-HSA-504054|Reactome:R-HSA-73647 go.json CTP synthetase activity|UTP--ammonia ligase activity|UTP:ammonia ligase (ADP-forming)|cytidine 5'-triphosphate synthetase activity|cytidine triphosphate synthetase activity|uridine triphosphate aminase activity http://purl.obolibrary.org/obo/GO_0003883 GO:0003882 biolink:MolecularActivity CDP-diacylglycerol-serine O-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. EC:2.7.8.8|MetaCyc:PHOSPHASERSYN-RXN|RHEA:16913 go.json CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|CDP-diglyceride-L-serine phosphatidyltransferase activity|CDP-diglyceride:serine phosphatidyltransferase activity|CDP-diglycerine-serine O-phosphatidyltransferase activity|CDPdiacylglycerol-serine O-phosphatidyltransferase activity|CDPdiglyceride-serine O-phosphatidyltransferase activity|PS synthase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|phosphatidylserine synthase activity|phosphatidylserine synthetase activity|serine exchange enzyme http://purl.obolibrary.org/obo/GO_0003882 GO:0003885 biolink:MolecularActivity D-arabinono-1,4-lactone oxidase activity Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+. EC:1.1.3.37|KEGG_REACTION:R02715|MetaCyc:1.1.3.37-RXN|RHEA:23756 go.json D-arabinono-1,4-lactone:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0003885 GO:0003884 biolink:MolecularActivity D-amino-acid oxidase activity Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. EC:1.4.3.3|MetaCyc:D-AMINO-ACID-OXIDASE-RXN|RHEA:21816|Reactome:R-HSA-389821 go.json D-amino-acid:oxygen oxidoreductase (deaminating)|L-amino acid:O2 oxidoreductase activity|new yellow enzyme http://purl.obolibrary.org/obo/GO_0003884 GO:0052899 biolink:MolecularActivity N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine. EC:1.5.3.13|MetaCyc:RXN-10460|RHEA:25868 go.json N(1)-acetylpolyamine oxidase activity|polyamine oxidase activity http://purl.obolibrary.org/obo/GO_0052899 GO:1904649 biolink:BiologicalProcess regulation of fat cell apoptotic process Any process that modulates the frequency, rate or extent of fat cell apoptotic process. go.json regulation of adipocyte apoptosis|regulation of adipocyte apoptotic process|regulation of adipose cell apoptosis|regulation of adipose cell apoptotic process|regulation of fat cell apoptosis http://purl.obolibrary.org/obo/GO_1904649 GO:1904648 biolink:BiologicalProcess cellular response to rotenone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus. go.json http://purl.obolibrary.org/obo/GO_1904648 GO:1904647 biolink:BiologicalProcess response to rotenone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus. go.json http://purl.obolibrary.org/obo/GO_1904647 GO:0003881 biolink:MolecularActivity CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+. EC:2.7.8.11|KEGG_REACTION:R01802|MetaCyc:2.7.8.11-RXN|RHEA:11580|Reactome:R-HSA-1482976 go.json CDP diglyceride-inositol phosphatidyltransferase activity|CDP-DG:inositol transferase activity|CDP-diacylglycerol--inositol phosphatidyltransferase activity|CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity|CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity|CDP-diglyceride-inositol transferase activity|CDP-diglyceride:inositol transferase activity|CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity|cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity|cytidine diphosphoglyceride-inositol phosphatidyltransferase activity|cytidine diphosphoglyceride-inositol transferase activity|phosphatidylinositol synthase activity http://purl.obolibrary.org/obo/GO_0003881 GO:1904646 biolink:BiologicalProcess cellular response to amyloid-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. go.json cellular response to beta-amyloid|cellular response to beta-amyloids http://purl.obolibrary.org/obo/GO_1904646 GO:1904645 biolink:BiologicalProcess response to amyloid-beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. go.json response to beta-amyloid|response to beta-amyloids http://purl.obolibrary.org/obo/GO_1904645 GO:0003880 biolink:MolecularActivity protein C-terminal carboxyl O-methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. go.json C-terminal protein carboxyl methyltransferase activity http://purl.obolibrary.org/obo/GO_0003880 GO:1904644 biolink:BiologicalProcess cellular response to curcumin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904644 GO:1904643 biolink:BiologicalProcess response to curcumin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904643 GO:0062200 biolink:BiologicalProcess RAM/MOR signaling pathway An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase. go.json MOR signaling pathway|RAM signaling pathway|morphogenesis Orb6 network http://purl.obolibrary.org/obo/GO_0062200 GO:1904642 biolink:BiologicalProcess cellular response to dinitrophenol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus. go.json cellular response to dinitrophenols http://purl.obolibrary.org/obo/GO_1904642 GO:1904641 biolink:BiologicalProcess response to dinitrophenol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus. go.json response to dinitrophenols http://purl.obolibrary.org/obo/GO_1904641 GO:1904651 biolink:BiologicalProcess positive regulation of fat cell apoptotic process Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. go.json activation of adipocyte apoptosis|activation of adipocyte apoptotic process|activation of adipose cell apoptosis|activation of adipose cell apoptotic process|activation of fat cell apoptosis|activation of fat cell apoptotic process|positive regulation of adipocyte apoptosis|positive regulation of adipocyte apoptotic process|positive regulation of adipose cell apoptosis|positive regulation of adipose cell apoptotic process|positive regulation of fat cell apoptosis|up regulation of adipocyte apoptosis|up regulation of adipocyte apoptotic process|up regulation of adipose cell apoptosis|up regulation of adipose cell apoptotic process|up regulation of fat cell apoptosis|up regulation of fat cell apoptotic process|up-regulation of adipocyte apoptosis|up-regulation of adipocyte apoptotic process|up-regulation of adipose cell apoptosis|up-regulation of adipose cell apoptotic process|up-regulation of fat cell apoptosis|up-regulation of fat cell apoptotic process|upregulation of adipocyte apoptosis|upregulation of adipocyte apoptotic process|upregulation of adipose cell apoptosis|upregulation of adipose cell apoptotic process|upregulation of fat cell apoptosis|upregulation of fat cell apoptotic process http://purl.obolibrary.org/obo/GO_1904651 GO:0062202 biolink:MolecularActivity Labd-13(16),14-diene-9-ol synthase activity Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol. RHEA:62184 go.json http://purl.obolibrary.org/obo/GO_0062202 GO:1904650 biolink:BiologicalProcess negative regulation of fat cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. go.json down regulation of adipocyte apoptosis|down regulation of adipocyte apoptotic process|down regulation of adipose cell apoptosis|down regulation of adipose cell apoptotic process|down regulation of fat cell apoptosis|down regulation of fat cell apoptotic process|down-regulation of adipocyte apoptosis|down-regulation of adipocyte apoptotic process|down-regulation of adipose cell apoptosis|down-regulation of adipose cell apoptotic process|down-regulation of fat cell apoptosis|down-regulation of fat cell apoptotic process|downregulation of adipocyte apoptosis|downregulation of adipocyte apoptotic process|downregulation of adipose cell apoptosis|downregulation of adipose cell apoptotic process|downregulation of fat cell apoptosis|downregulation of fat cell apoptotic process|inhibition of adipocyte apoptosis|inhibition of adipocyte apoptotic process|inhibition of adipose cell apoptosis|inhibition of adipose cell apoptotic process|inhibition of fat cell apoptosis|inhibition of fat cell apoptotic process|negative regulation of adipocyte apoptosis|negative regulation of adipocyte apoptotic process|negative regulation of adipose cell apoptosis|negative regulation of adipose cell apoptotic process|negative regulation of fat cell apoptosis http://purl.obolibrary.org/obo/GO_1904650 GO:0062201 biolink:CellularComponent actin wave A cellular anatomical entity that is part of the actin cytoskeleton and results in a wave-like propagation of actin networks. It consists of dynamic structures traveling on the ventral (substrate-attached) side of the cell during cell migration, cytokinesis, adhesion and neurogenesis. go.json http://purl.obolibrary.org/obo/GO_0062201 GO:0062204 biolink:MolecularActivity (13S)-vitexifolin A synthase activity Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate. RHEA:40027 go.json http://purl.obolibrary.org/obo/GO_0062204 GO:0062203 biolink:MolecularActivity Viteagnusin D synthase activity Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D. RHEA:62180 go.json http://purl.obolibrary.org/obo/GO_0062203 GO:0062206 biolink:MolecularActivity manoyl oxide synthase activity Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate. EC:4.2.3.190|RHEA:54516 go.json http://purl.obolibrary.org/obo/GO_0062206 GO:0062205 biolink:MolecularActivity miltiradiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene. EC:4.2.3.131|MetaCyc:RXN-13338|RHEA:33983 go.json multiradiene synthase activity http://purl.obolibrary.org/obo/GO_0062205 GO:0062208 biolink:BiologicalProcess positive regulation of pattern recognition receptor signaling pathway Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0062208 GO:0062207 biolink:BiologicalProcess regulation of pattern recognition receptor signaling pathway Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0062207 GO:0052890 biolink:MolecularActivity oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. EC:1.3.8.- go.json http://purl.obolibrary.org/obo/GO_0052890 GO:0062209 biolink:BiologicalProcess spatial regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that modulates the distribution of sites along the chromosome where meiotic DNA double-strand break formation takes place as part of reciprocal meiotic recombination. go.json DSB interference|crossover interference|regulation of spatial distribution of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|regulation of spatial distribution of meiotic DSB formation involved in reciprocal meiotic recombination http://purl.obolibrary.org/obo/GO_0062209 GO:0052894 biolink:MolecularActivity norspermine:oxygen oxidoreductase activity Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. EC:1.5.3.16|MetaCyc:RXN-10464|RHEA:25816 go.json norspermine oxidase activity http://purl.obolibrary.org/obo/GO_0052894 GO:0052893 biolink:MolecularActivity N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide. EC:1.5.3.14|MetaCyc:RXN-10465|RHEA:25996 go.json polyamine oxidase (propane-1,3-diamine-forming) activity http://purl.obolibrary.org/obo/GO_0052893 GO:0052892 biolink:MolecularActivity aromatic (S)-hydroxynitrile lyase activity Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide. KEGG_REACTION:R09359|MetaCyc:RXN-11732|RHEA:54660|https://github.com/geneontology/go-ontology/issues/16166 go.json http://purl.obolibrary.org/obo/GO_0052892 GO:0052891 biolink:MolecularActivity aliphatic (S)-hydroxynitrile lyase activity Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide. MetaCyc:RXN-11731|https://github.com/geneontology/go-ontology/issues/16166 go.json (S)-cyanohydrin carbonyl-lyase (cyanide forming) activity|(S)-cyanohydrin producing hydroxynitrile lyase activity|(S)-hydroxynitrile lyase activity|(S)-oxynitrilase activity|(S)-selective hydroxynitrile lyase activity http://purl.obolibrary.org/obo/GO_0052891 GO:0003854 biolink:MolecularActivity 3-beta-hydroxy-delta5-steroid dehydrogenase activity Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+. EC:1.1.1.145|MetaCyc:1.1.1.145-RXN|RHEA:24076|Reactome:R-HSA-192097|Reactome:R-HSA-193789|Reactome:R-HSA-193816|Reactome:R-HSA-196350|Reactome:R-HSA-196372 go.json 3-beta-hydroxy-5-ene steroid dehydrogenase activity|3-beta-hydroxy-D5-steroid dehydrogenase activity|3beta-HSDH|3beta-hydroxy steroid dehydrogenase/isomerase activity|3beta-hydroxy-5-ene steroid dehydrogenase activity|3beta-hydroxy-5-ene-steroid dehydrogenase activity|3beta-hydroxy-5-ene-steroid oxidoreductase activity|3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity|3beta-hydroxy-delta5-C27-steroid oxidoreductase|3beta-hydroxy-delta5-steroid dehydrogenase activity|3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity|5-ene-3-beta-hydroxysteroid dehydrogenase activity|delta5-3beta-hydroxysteroid dehydrogenase activity|progesterone reductase activity|steroid-delta5-3beta-ol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003854 GO:0003853 biolink:MolecularActivity 2-methylacyl-CoA dehydrogenase activity Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]. EC:1.3.8.5|KEGG_REACTION:R03169|MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN|RHEA:43780 go.json 2-methyl branched chain acyl-CoA dehydrogenase activity|2-methyl-branched-chain-enoyl-CoA reductase activity|branched-chain acyl-CoA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003853 GO:0003856 biolink:MolecularActivity 3-dehydroquinate synthase activity Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. EC:4.2.3.4|KEGG_REACTION:R03083|MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN|RHEA:21968 go.json http://purl.obolibrary.org/obo/GO_0003856 GO:0003855 biolink:MolecularActivity 3-dehydroquinate dehydratase activity Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. EC:4.2.1.10|KEGG_REACTION:R03084|MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN|RHEA:21096 go.json 3-dehydroquinase activity|3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)|3-dehydroquinate hydro-lyase activity|3-dehydroquinate hydrolase activity|5-dehydroquinase activity|5-dehydroquinate dehydratase activity|5-dehydroquinate hydro-lyase activity|DHQase|dehydroquinase activity|dehydroquinate dehydratase activity http://purl.obolibrary.org/obo/GO_0003855 GO:0003850 biolink:MolecularActivity 2-deoxyglucose-6-phosphatase activity Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate. EC:3.1.3.68|KEGG_REACTION:R02587|MetaCyc:3.1.3.68-RXN|RHEA:22236 go.json 2-deoxy-D-glucose-6-phosphate phosphohydrolase activity|2-deoxyglucose-6-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0003850 GO:0003852 biolink:MolecularActivity 2-isopropylmalate synthase activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. EC:2.3.3.13|KEGG_REACTION:R01213|MetaCyc:2-ISOPROPYLMALATESYN-RXN|RHEA:21524 go.json 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity|acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|alpha-IPM synthetase activity|alpha-isopropylmalate synthase activity|alpha-isopropylmalate synthetase activity|alpha-isopropylmalic synthetase activity|isopropylmalate synthase activity|isopropylmalate synthetase activity http://purl.obolibrary.org/obo/GO_0003852 GO:0003851 biolink:MolecularActivity 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. EC:2.4.1.47|MetaCyc:2.4.1.45-RXN|RHEA:10856 go.json UDP-galactose-ceramide galactosyltransferase activity|UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity|UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity|UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity|UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity|UDPgalactose:ceramide galactosyltransferase activity|cerebroside synthase activity|uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0003851 GO:1904659 biolink:BiologicalProcess glucose transmembrane transport The process in which glucose is transported across a membrane. go.json glucose transport http://purl.obolibrary.org/obo/GO_1904659 GO:1904658 biolink:BiologicalProcess positive regulation of sensory perception of sweet taste Any process that activates or increases the frequency, rate or extent of sensory perception of sweet taste. go.json activation of sensory perception of sweet taste|activation of sweet taste perception|positive regulation of sweet taste perception|up regulation of sensory perception of sweet taste|up regulation of sweet taste perception|up-regulation of sensory perception of sweet taste|up-regulation of sweet taste perception|upregulation of sensory perception of sweet taste|upregulation of sweet taste perception http://purl.obolibrary.org/obo/GO_1904658 GO:1904657 biolink:BiologicalProcess negative regulation of sensory perception of sweet taste Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of sweet taste. go.json down regulation of sensory perception of sweet taste|down regulation of sweet taste perception|down-regulation of sensory perception of sweet taste|down-regulation of sweet taste perception|downregulation of sensory perception of sweet taste|downregulation of sweet taste perception|inhibition of sensory perception of sweet taste|inhibition of sweet taste perception|negative regulation of sweet taste perception http://purl.obolibrary.org/obo/GO_1904657 GO:1904656 biolink:BiologicalProcess regulation of sensory perception of sweet taste Any process that modulates the frequency, rate or extent of sensory perception of sweet taste. go.json regulation of sweet taste perception http://purl.obolibrary.org/obo/GO_1904656 GO:1904655 biolink:BiologicalProcess positive regulation of lung alveolus development Any process that activates or increases the frequency, rate or extent of lung alveolus development. go.json activation of alveolarization|activation of alveologenesis|activation of lung alveolus development|positive regulation of alveolarization|positive regulation of alveologenesis|up regulation of alveolarization|up regulation of alveologenesis|up regulation of lung alveolus development|up-regulation of alveolarization|up-regulation of alveologenesis|up-regulation of lung alveolus development|upregulation of alveolarization|upregulation of alveologenesis|upregulation of lung alveolus development http://purl.obolibrary.org/obo/GO_1904655 GO:0062231 biolink:BiologicalProcess positive regulation of larval somatic muscle development Any process that increases the rate, frequency or extent of larval somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062231 GO:0062230 biolink:BiologicalProcess negative regulation of larval somatic muscle development Any process that decreases the rate, frequency or extent of larval somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062230 GO:1904654 biolink:BiologicalProcess negative regulation of lung alveolus development Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. go.json down regulation of alveolarization|down regulation of alveologenesis|down regulation of lung alveolus development|down-regulation of alveolarization|down-regulation of alveologenesis|down-regulation of lung alveolus development|downregulation of alveolarization|downregulation of alveologenesis|downregulation of lung alveolus development|inhibition of alveolarization|inhibition of alveologenesis|inhibition of lung alveolus development|negative regulation of alveolarization|negative regulation of alveologenesis http://purl.obolibrary.org/obo/GO_1904654 GO:1904653 biolink:BiologicalProcess regulation of lung alveolus development Any process that modulates the frequency, rate or extent of lung alveolus development. go.json regulation of alveolarization|regulation of alveologenesis http://purl.obolibrary.org/obo/GO_1904653 GO:0062233 biolink:BiologicalProcess F2-isoprostane catabolic process The chemical reactions and pathways resulting in the breakdown of F2-isoprostane. go.json http://purl.obolibrary.org/obo/GO_0062233 GO:1904652 biolink:BiologicalProcess protein localization to cell division site involved in cell separation after cytokinesis Any protein localization to cell division site that is involved in cell separation after cytokinesis. go.json http://purl.obolibrary.org/obo/GO_1904652 GO:0062232 biolink:BiologicalProcess prostanoid catabolic process The chemical reactions and pathways resulting in the breakdown of prostanoids. go.json http://purl.obolibrary.org/obo/GO_0062232 GO:0062235 biolink:BiologicalProcess axonemal basal plate assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal basal plate. go.json axonemal basal plate formation|axoneme basal plate assembly|basal plate assembly http://purl.obolibrary.org/obo/GO_0062235 GO:1904662 biolink:BiologicalProcess positive regulation of sensory perception of bitter taste Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste. go.json activation of bitter taste perception|activation of sensory perception of bitter taste|positive regulation of bitter taste perception|up regulation of bitter taste perception|up regulation of sensory perception of bitter taste|up-regulation of bitter taste perception|up-regulation of sensory perception of bitter taste|upregulation of bitter taste perception|upregulation of sensory perception of bitter taste http://purl.obolibrary.org/obo/GO_1904662 GO:0062234 biolink:BiologicalProcess platelet activating factor catabolic process The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine. go.json 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process|PAF catabolic process http://purl.obolibrary.org/obo/GO_0062234 GO:1904661 biolink:BiologicalProcess negative regulation of sensory perception of bitter taste Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste. go.json down regulation of bitter taste perception|down regulation of sensory perception of bitter taste|down-regulation of bitter taste perception|down-regulation of sensory perception of bitter taste|downregulation of bitter taste perception|downregulation of sensory perception of bitter taste|inhibition of bitter taste perception|inhibition of sensory perception of bitter taste|negative regulation of bitter taste perception http://purl.obolibrary.org/obo/GO_1904661 GO:0062237 biolink:BiologicalProcess protein localization to postsynapse Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. go.json http://purl.obolibrary.org/obo/GO_0062237 GO:1904660 biolink:BiologicalProcess regulation of sensory perception of bitter taste Any process that modulates the frequency, rate or extent of sensory perception of bitter taste. go.json regulation of bitter taste perception http://purl.obolibrary.org/obo/GO_1904660 GO:0062236 biolink:BiologicalProcess ionocyte differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an ionocyte. Ionocytes are specialized epithelial cells that contribute to osmotic homeostasis. go.json http://purl.obolibrary.org/obo/GO_0062236 GO:0062239 biolink:MolecularActivity heterochromatin-nuclear membrane anchor activity Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization. go.json heterochromatin-nuclear membrane tether activity|nuclear membrane-heterochromatin anchor activity|nuclear membrane-heterochromatin tether activity http://purl.obolibrary.org/obo/GO_0062239 GO:0062238 biolink:CellularComponent Smp focus A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I. go.json Smp dot http://purl.obolibrary.org/obo/GO_0062238 GO:0003858 biolink:MolecularActivity 3-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH. EC:1.1.1.30|KEGG_REACTION:R01361|MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN|RHEA:20521|Reactome:R-HSA-5696457|Reactome:R-HSA-73912|Reactome:R-HSA-73920 go.json D-beta-hydroxybutyrate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003858 GO:0003857 biolink:MolecularActivity 3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. EC:1.1.1.35|MetaCyc:OHACYL-COA-DEHYDROG-RXN|RHEA:22432|Reactome:R-HSA-193455|Reactome:R-HSA-193508|Reactome:R-HSA-389995|Reactome:R-HSA-390251|Reactome:R-HSA-508369|Reactome:R-HSA-6809264|Reactome:R-HSA-70837|Reactome:R-HSA-77254|Reactome:R-HSA-77283|Reactome:R-HSA-77303|Reactome:R-HSA-77312|Reactome:R-HSA-77323|Reactome:R-HSA-77331|Reactome:R-HSA-77342|UM-BBD_enzymeID:e0664 go.json 3-oxoacyl-thioester reductase activity|L-3-hydroxyacyl CoA dehydrogenase activity|L-3-hydroxyacyl coenzyme A dehydrogenase activity|beta-hydroxyacyl dehydrogenase activity|beta-hydroxyacyl-coenzyme A synthetase activity|beta-hydroxyacylcoenzyme A dehydrogenase activity|beta-hydroxybutyrylcoenzyme A dehydrogenase activity|beta-keto-reductase activity|beta-ketoacyl-CoA reductase http://purl.obolibrary.org/obo/GO_0003857 GO:0003859 biolink:MolecularActivity obsolete (3R)-3-hydroxybutyryl-CoA dehydratase activity OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O. go.json (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)|(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity|3-hydroxybutyryl-CoA dehydratase activity|D-3-hydroxybutyryl coenzyme A dehydratase activity|D-3-hydroxybutyryl-CoA dehydratase activity|crotonase activity|enoyl coenzyme A hydrase (D) True http://purl.obolibrary.org/obo/GO_0003859 GO:0003865 biolink:MolecularActivity 3-oxo-5-alpha-steroid 4-dehydrogenase activity Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. EC:1.3.99.5|MetaCyc:1.3.99.5-RXN|Reactome:R-HSA-469659|Reactome:R-HSA-9705713|Reactome:R-HSA-9705714 go.json 3-keto-delta4-steroid-5alpha-reductase activity|3-oxo-5alpha-steroid 4-dehydrogenase activity|3-oxo-5alpha-steroid delta4-dehydrogenase activity|3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity|3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity|3-oxosteroid delta4-dehydrogenase|4-ene-3-ketosteroid-5alpha-oxidoreductase activity|5alpha-reductase|delta4-3-keto steroid 5alpha-reductase activity|delta4-3-ketosteroid5alpha-oxidoreductase activity|delta4-3-oxo steroid reductase activity|delta4-3-oxosteroid-5alpha-reductase|delta4-5alpha-dehydrogenase activity|steroid 5 alpha reductase|steroid 5-alpha-reductase activity|steroid 5alpha-reductase|steroid delta4-5alpha-reductase activity|testosterone 5alpha-reductase http://purl.obolibrary.org/obo/GO_0003865 GO:0003864 biolink:MolecularActivity 3-methyl-2-oxobutanoate hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. EC:2.1.2.11|MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN|RHEA:11824 go.json 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity|5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity|alpha-ketoisovalerate hydroxymethyltransferase activity|dehydropantoate hydroxymethyltransferase activity|ketopantoate hydroxymethyltransferase activity|oxopantoate hydroxymethyltransferase activity http://purl.obolibrary.org/obo/GO_0003864 GO:0003867 biolink:MolecularActivity 4-aminobutyrate transaminase activity Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. MetaCyc:GABATRANSAM-RXN|RHEA:23352|Reactome:R-HSA-916855 go.json 4-aminobutanoate transaminase activity|4-aminobutyrate aminotransferase activity|4-aminobutyric acid aminotransferase activity|GABA aminotransferase activity|GABA transaminase activity|GABA transferase activity|aminobutyrate aminotransferase activity|aminobutyrate transaminase activity|beta-alanine aminotransferase|gamma-amino-N-butyrate transaminase activity|gamma-aminobutyrate aminotransaminase activity|gamma-aminobutyrate transaminase activity|gamma-aminobutyric acid aminotransferase activity|gamma-aminobutyric acid transaminase activity|gamma-aminobutyric transaminase activity|glutamate-succinic semialdehyde transaminase activity http://purl.obolibrary.org/obo/GO_0003867 GO:0003866 biolink:MolecularActivity 3-phosphoshikimate 1-carboxyvinyltransferase activity Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate. EC:2.5.1.19|KEGG_REACTION:R03460|MetaCyc:2.5.1.19-RXN|RHEA:21256 go.json 3-enol-pyruvoylshikimate-5-phosphate synthase activity|5-enolpyruvylshikimate-3-phosphate synthase activity|EPSP synthase activity|phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity http://purl.obolibrary.org/obo/GO_0003866 GO:0003861 biolink:MolecularActivity 3-isopropylmalate dehydratase activity Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. EC:4.2.1.33|MetaCyc:3-ISOPROPYLMALISOM-RXN|RHEA:32287 go.json (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)|(2R,3S)-3-isopropylmalate hydro-lyase activity|alpha-IPM isomerase activity|alpha-isopropylmalate isomerase activity|beta-isopropylmalate dehydratase activity|isopropylmalate isomerase activity http://purl.obolibrary.org/obo/GO_0003861 GO:0003860 biolink:MolecularActivity 3-hydroxyisobutyryl-CoA hydrolase activity Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. EC:3.1.2.4|MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN|RHEA:20888|Reactome:R-HSA-70881 go.json 3-hydroxy-2-methylpropanoyl-CoA hydrolase activity|3-hydroxy-isobutyryl CoA hydrolase activity|HIB CoA deacylase activity http://purl.obolibrary.org/obo/GO_0003860 GO:0003863 biolink:MolecularActivity 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. EC:1.2.4.4|MetaCyc:1.2.4.4-RXN|RHEA:13457 go.json 2-oxoisocaproate dehydrogenase activity|2-oxoisovalerate (lipoate) dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity|3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)|3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity|BCKDH activity|BCOAD activity|alpha-keto-alpha-methylvalerate dehydrogenase activity|alpha-ketoacid dehydrogenase activity|alpha-ketoisocaproate dehydrogenase activity|alpha-ketoisocaproic dehydrogenase activity|alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity|alpha-ketoisovalerate dehydrogenase activity|alpha-oxoisocaproate dehydrogenase activity|branched chain keto acid dehydrogenase activity|branched-chain (-2-oxoacid) dehydrogenase (BCD) activity|branched-chain 2-keto acid dehydrogenase activity|branched-chain 2-oxo acid dehydrogenase activity|branched-chain alpha-keto acid dehydrogenase activity|branched-chain alpha-oxo acid dehydrogenase activity|branched-chain keto acid dehydrogenase activity|branched-chain ketoacid dehydrogenase activity|dehydrogenase, 2-oxoisovalerate (lipoate) activity|dehydrogenase, branched chain alpha-keto acid activity http://purl.obolibrary.org/obo/GO_0003863 GO:0003862 biolink:MolecularActivity 3-isopropylmalate dehydrogenase activity Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. EC:1.1.1.85|MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN|RHEA:32271 go.json (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity|3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity|IMDH activity|IPMDH|beta-IPM dehydrogenase activity|beta-isopropylmalate dehydrogenase activity|beta-isopropylmalic enzyme|threo-Ds-3-isopropylmalate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003862 GO:1904669 biolink:BiologicalProcess ATP export The directed movement of ATP out of a cell or organelle. go.json ATP efflux http://purl.obolibrary.org/obo/GO_1904669 GO:1904668 biolink:BiologicalProcess positive regulation of ubiquitin protein ligase activity Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. go.json activation of APC-Cdc20 complex activity|activation of APC-fizzy related complex activity|activation of E3|activation of anaphase-promoting complex activity|activation of protein ubiquitination activity|activation of ubiquitin ligase activity|activation of ubiquitin protein ligase activity|positive regulation of APC-fizzy related complex activity|positive regulation of E3|positive regulation of protein ubiquitination activity|positive regulation of ubiquitin ligase activity|up regulation of APC-fizzy related complex activity|up regulation of E3|up regulation of protein ubiquitination activity|up regulation of ubiquitin ligase activity|up regulation of ubiquitin protein ligase activity|up-regulation of APC-fizzy related complex activity|up-regulation of E3|up-regulation of protein ubiquitination activity|up-regulation of ubiquitin ligase activity|up-regulation of ubiquitin protein ligase activity|upregulation of APC-fizzy related complex activity|upregulation of E3|upregulation of protein ubiquitination activity|upregulation of ubiquitin ligase activity|upregulation of ubiquitin protein ligase activity http://purl.obolibrary.org/obo/GO_1904668 gocheck_do_not_annotate GO:1904667 biolink:BiologicalProcess negative regulation of ubiquitin protein ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. go.json down regulation of E3|down regulation of protein ubiquitination activity|down regulation of ubiquitin ligase activity|down regulation of ubiquitin protein ligase activity|down-regulation of E3|down-regulation of protein ubiquitination activity|down-regulation of ubiquitin ligase activity|down-regulation of ubiquitin protein ligase activity|downregulation of E3|downregulation of protein ubiquitination activity|downregulation of ubiquitin ligase activity|downregulation of ubiquitin protein ligase activity|inhibition of E3|inhibition of protein ubiquitination activity|inhibition of ubiquitin ligase activity|inhibition of ubiquitin protein ligase activity|negative regulation of APC activity during mitotic cell cycle|negative regulation of APC-Cdc20 complex activity|negative regulation of APC-fizzy related complex activity|negative regulation of APC/C activity during mitotic cell cycle|negative regulation of E3|negative regulation of anaphase-promoting complex activity during mitotic cell cycle|negative regulation of cyclosome activity during mitotic cell cycle|negative regulation of mitotic anaphase-promoting complex activity|negative regulation of protein ubiquitination activity|negative regulation of ubiquitin ligase activity http://purl.obolibrary.org/obo/GO_1904667 gocheck_do_not_annotate GO:1904666 biolink:BiologicalProcess regulation of ubiquitin protein ligase activity Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. go.json regulation of APC-fizzy related complex activity|regulation of E3|regulation of protein ubiquitination activity|regulation of ubiquitin ligase activity http://purl.obolibrary.org/obo/GO_1904666 gocheck_do_not_annotate GO:1904665 biolink:BiologicalProcess positive regulation of N-terminal peptidyl-methionine acetylation Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. go.json http://purl.obolibrary.org/obo/GO_1904665 GO:1904664 biolink:BiologicalProcess negative regulation of N-terminal peptidyl-methionine acetylation Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. go.json http://purl.obolibrary.org/obo/GO_1904664 GO:1904663 biolink:BiologicalProcess regulation of N-terminal peptidyl-methionine acetylation Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. go.json http://purl.obolibrary.org/obo/GO_1904663 GO:1904673 biolink:BiologicalProcess negative regulation of somatic stem cell population maintenance Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance. go.json down regulation of somatic stem cell population maintenance|down-regulation of somatic stem cell population maintenance|downregulation of somatic stem cell population maintenance|inhibition of somatic stem cell population maintenance http://purl.obolibrary.org/obo/GO_1904673 GO:0062224 biolink:BiologicalProcess positive regulation of somatic muscle development Any process that increases the rate, frequency or extent of somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062224 GO:1904672 biolink:BiologicalProcess regulation of somatic stem cell population maintenance Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance. go.json http://purl.obolibrary.org/obo/GO_1904672 GO:0062223 biolink:BiologicalProcess regulation of somatic muscle development Any process that regulates the rate, frequency or extent of somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062223 GO:1904671 biolink:BiologicalProcess negative regulation of cell differentiation involved in stem cell population maintenance Any negative regulation of cell differentiation that is involved in stem cell population maintenance. go.json down regulation of cell differentiation involved in maintenance of pluripotency|down regulation of cell differentiation involved in stem cell population maintenance|down-regulation of cell differentiation involved in maintenance of pluripotency|down-regulation of cell differentiation involved in stem cell population maintenance|downregulation of cell differentiation involved in maintenance of pluripotency|downregulation of cell differentiation involved in stem cell population maintenance|inhibition of cell differentiation involved in maintenance of pluripotency|inhibition of cell differentiation involved in stem cell population maintenance|negative regulation of cell differentiation involved in maintenance of pluripotency http://purl.obolibrary.org/obo/GO_1904671 GO:0062226 biolink:BiologicalProcess regulation of adult somatic muscle development Any process that modulates the rate, frequency or extent of adult somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062226 GO:1904670 biolink:BiologicalProcess obsolete actin filament polymerization involved in mitotic actomyosin contractile ring assembly OBSOLETE. Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly. go.json True http://purl.obolibrary.org/obo/GO_1904670 GO:0062225 biolink:BiologicalProcess negative regulation of somatic muscle development Any process that decreases the rate, frequency or extent of somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062225 GO:0062228 biolink:BiologicalProcess negative regulation of adult somatic muscle development Any process that decreases the rate, frequency or extent of adult somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062228 GO:0062227 biolink:BiologicalProcess positive regulation of adult somatic muscle development Any process that increases the rate, frequency or extent of adult somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062227 GO:0062229 biolink:BiologicalProcess regulation of larval somatic muscle development Any process that modulates the rate, frequency or extent of larval somatic muscle development. go.json http://purl.obolibrary.org/obo/GO_0062229 GO:0003869 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003869 GO:0003868 biolink:MolecularActivity 4-hydroxyphenylpyruvate dioxygenase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. EC:1.13.11.27|MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN|RHEA:16189|Reactome:R-HSA-71163|UM-BBD_reactionID:r0298 go.json 4-hydroxyphenylpyruvate hydroxylase activity|4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)|4-hydroxyphenylpyruvic acid dioxygenase activity|p-hydroxyphenylpyruvate dioxygenase activity|p-hydroxyphenylpyruvate hydroxylase activity|p-hydroxyphenylpyruvate oxidase activity|p-hydroxyphenylpyruvic acid hydroxylase activity|p-hydroxyphenylpyruvic hydroxylase activity|p-hydroxyphenylpyruvic oxidase activity http://purl.obolibrary.org/obo/GO_0003868 GO:0052803 biolink:BiologicalProcess imidazole-containing compound metabolic process The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. go.json imidazole metabolism http://purl.obolibrary.org/obo/GO_0052803 GO:0052802 biolink:BiologicalProcess nitroimidazole metabolic process The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. go.json nitroimidazole metabolism http://purl.obolibrary.org/obo/GO_0052802 GO:0052801 biolink:BiologicalProcess bicyclic nitroimidazole metabolic process The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring. go.json bicyclic nitroimidazole metabolism http://purl.obolibrary.org/obo/GO_0052801 GO:0052800 biolink:BiologicalProcess bicyclic nitroimidazole catabolic process The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole. go.json bicyclic nitroimidazole breakdown|bicyclic nitroimidazole catabolism|bicyclic nitroimidazole degradation http://purl.obolibrary.org/obo/GO_0052800 GO:0052807 biolink:MolecularActivity aflatoxin reductase (coenzyme F420) activity Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. go.json aflatoxin:coenzyme F420 oxidoreductase activity|aflatoxin:reduced coenzyme F420 reductase activity|coenzyme F420-aflatoxin reductase activity|coenzyme F420-dependent aflatoxin reductase activity http://purl.obolibrary.org/obo/GO_0052807 GO:0052806 biolink:MolecularActivity sulfite reductase (coenzyme F420) activity Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. go.json coenzyme F420-dependent sulfite reductase activity|coenzyme F420-sulfite reductase activity|hydrogen-sulfide:coenzyme F420 oxidoreductase activity|sulfite:reduced coenzyme F420 reductase activity http://purl.obolibrary.org/obo/GO_0052806 GO:0052805 biolink:BiologicalProcess imidazole-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. go.json imidazole breakdown|imidazole catabolism|imidazole degradation http://purl.obolibrary.org/obo/GO_0052805 GO:0052804 biolink:BiologicalProcess nitroimidazole catabolic process The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. go.json nitroimidazole breakdown|nitroimidazole catabolism|nitroimidazole degradation http://purl.obolibrary.org/obo/GO_0052804 GO:0052809 biolink:MolecularActivity acharan sulfate lyase activity Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid. go.json http://purl.obolibrary.org/obo/GO_0052809 GO:0052808 biolink:MolecularActivity reduced coenzyme F420:NADP+ oxidoreductase activity Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. EC:1.5.1.40 go.json F420H2:NADP oxidoreductase activity|F420H2:NADP+ oxidoreductase activity|NADP+:F420 oxidoreductase activity|coenzyme F420-dependent NADP oxidoreductase activity|coenzyme F420-dependent NADP reductase activity http://purl.obolibrary.org/obo/GO_0052808 GO:0052810 biolink:MolecularActivity 1-phosphatidylinositol-5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+. RHEA:44680|Reactome:R-HSA-1675810|Reactome:R-HSA-1675866 go.json 1-phosphatidylinositol 5-kinase activity http://purl.obolibrary.org/obo/GO_0052810 GO:0052814 biolink:MolecularActivity medium-chain-aldehyde dehydrogenase activity Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons. EC:1.2.1.- go.json medium-chain aliphatic aldehyde dehydrogenase activity|medium-chain fatty aldehyde dehydrogenase activity|medium-chain-aldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052814 GO:0052813 biolink:MolecularActivity obsolete phosphatidylinositol bisphosphate kinase activity OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate. go.json True http://purl.obolibrary.org/obo/GO_0052813 GO:0052812 biolink:MolecularActivity obsolete 1-phosphatidylinositol-3,4-bisphosphate 5-kinase activity OBSOLETE. Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+. go.json phosphatidylinositol-3,4-bisphosphate 5-kinase activity True http://purl.obolibrary.org/obo/GO_0052812 GO:0052811 biolink:MolecularActivity 1-phosphatidylinositol-3-phosphate 4-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+. RHEA:63688|Reactome:R-HSA-1676145 go.json phosphatidylinositol 3-phosphate 4-kinase activity http://purl.obolibrary.org/obo/GO_0052811 GO:0052818 biolink:MolecularActivity heteroglycan 3-alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP. EC:2.4.1.48|KEGG_REACTION:R03769|MetaCyc:RXN-7992 go.json GDP mannose 3-alpha-mannosyltransferase activity|GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity|guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity|heteropolysaccharide 3-alpha-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0052818 GO:0052817 biolink:MolecularActivity very long chain acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18. go.json very long-chain acyl coenzyme A hydrolase activity|very long-chain acyl-thioester hydrolase activity|very long-chain hydrolase activity|very long-chain-acyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0052817 GO:0052816 biolink:MolecularActivity long-chain acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length. go.json long-chain acyl coenzyme A hydrolase activity|long-chain acyl-thioester hydrolase activity|long-chain hydrolase activity|long-chain-acyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0052816 GO:0052815 biolink:MolecularActivity medium-chain acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length. go.json medium-chain acyl coenzyme A hydrolase activity|medium-chain acyl-thioester hydrolase activity|medium-chain hydrolase activity|medium-chain-acyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0052815 GO:0052819 biolink:MolecularActivity heteroglycan 2-alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP. EC:2.4.1.48|KEGG_REACTION:R03768|MetaCyc:2.4.1.48-RXN go.json GDP mannose 2-alpha-mannosyltransferase activity|GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity|guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity|heteropolysaccharide 2-alpha-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0052819 GO:0052821 biolink:MolecularActivity DNA-7-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site. EC:3.2.2.21|MetaCyc:3.2.2.21-RXN go.json http://purl.obolibrary.org/obo/GO_0052821 GO:0052820 biolink:MolecularActivity DNA-1,N6-ethenoadenine N-glycosylase activity Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. go.json 1,N(6)-ethenoadenine N-glycosylase activity|1,N6-ethenoadenine glycosylase activity http://purl.obolibrary.org/obo/GO_0052820 GO:0052825 biolink:MolecularActivity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate. Reactome:R-HSA-1855219 go.json http://purl.obolibrary.org/obo/GO_0052825 GO:0052824 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052824 GO:0052823 biolink:MolecularActivity 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+. EC:3.7.1.14|MetaCyc:RXN-12070|RHEA:25046|UM-BBD_reactionID:r1622 go.json (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity|2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity http://purl.obolibrary.org/obo/GO_0052823 GO:0052822 biolink:MolecularActivity DNA-3-methylguanine glycosylase activity Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site. EC:3.2.2.21|MetaCyc:3.2.2.21-RXN go.json 3-methylguanine DNA glycosylase I|DNA glycosidase I activity|alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)|deoxyribonucleate 3-methylguanine glycosidase I http://purl.obolibrary.org/obo/GO_0052822 GO:0052829 biolink:MolecularActivity inositol-1,3,4-trisphosphate 1-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. Reactome:R-HSA-1855232 go.json http://purl.obolibrary.org/obo/GO_0052829 GO:0052828 biolink:MolecularActivity inositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate. RHEA:43388|Reactome:R-HSA-1855202 go.json http://purl.obolibrary.org/obo/GO_0052828 GO:0052827 biolink:MolecularActivity inositol pentakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0052827 GO:0052826 biolink:MolecularActivity inositol hexakisphosphate 2-phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate. EC:3.1.3.62|Reactome:R-HSA-1855225 go.json 1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0052826 GO:0052832 biolink:MolecularActivity inositol monophosphate 3-phosphatase activity Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate. EC:3.1.3.25|MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN|RHEA:30739|Reactome:R-HSA-1855210 go.json http://purl.obolibrary.org/obo/GO_0052832 GO:0052831 biolink:MolecularActivity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate. Reactome:R-HSA-1855159 go.json http://purl.obolibrary.org/obo/GO_0052831 GO:0052830 biolink:MolecularActivity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate. Reactome:R-HSA-1855171 go.json http://purl.obolibrary.org/obo/GO_0052830 GO:0052836 biolink:MolecularActivity inositol 5-diphosphate pentakisphosphate 5-kinase activity Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate. Reactome:R-HSA-1855158|Reactome:R-HSA-1855224 go.json http://purl.obolibrary.org/obo/GO_0052836 GO:0052835 biolink:MolecularActivity inositol-3,4,6-trisphosphate 1-kinase activity Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+. Reactome:R-HSA-1855169 go.json 1D-myo-inositol-trisphosphate 1-kinase activity|ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity|IP3 1-kinase activity|Ins(3,4,6)P3 1-kinase activity|inositol 3,4,6-trisphosphate 1-kinase activity|inositol-trisphosphate 1-kinase activity|ins(3,4,6)P(3) 1-kinase activity http://purl.obolibrary.org/obo/GO_0052835 GO:0052834 biolink:MolecularActivity inositol monophosphate phosphatase activity Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. EC:3.1.3.25|MetaCyc:RXN-10949|RHEA:24056 go.json L-myo-inositol-phosphate phosphatase activity|inositol phosphatase activity|inositol-1(or 4)-monophosphatase activity|inositol-phosphate phosphatase activity|myo-inositol monophosphatase activity|myo-inositol phosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity|myo-inositol-phosphatase activity|myo-inositol-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0052834 GO:0052833 biolink:MolecularActivity inositol monophosphate 4-phosphatase activity Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate. EC:3.1.3.25|MetaCyc:RXN-10952|RHEA:30735|Reactome:R-HSA-1855211 go.json inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0052833 GO:0052839 biolink:MolecularActivity inositol diphosphate tetrakisphosphate kinase activity Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate. Reactome:R-HSA-1855193|Reactome:R-HSA-1855230 go.json http://purl.obolibrary.org/obo/GO_0052839 GO:0052838 biolink:BiologicalProcess thiazole metabolic process The chemical reactions and pathways involving thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. go.json thiazole metabolism http://purl.obolibrary.org/obo/GO_0052838 GO:0052837 biolink:BiologicalProcess thiazole biosynthetic process The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. go.json thiazole anabolism|thiazole biosynthesis|thiazole formation|thiazole synthesis http://purl.obolibrary.org/obo/GO_0052837 GO:1904559 biolink:BiologicalProcess cellular response to dextromethorphan Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus. go.json http://purl.obolibrary.org/obo/GO_1904559 GO:1904558 biolink:BiologicalProcess response to dextromethorphan Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus. go.json http://purl.obolibrary.org/obo/GO_1904558 GO:1904557 biolink:BiologicalProcess L-alanine transmembrane transport The directed movement of L-alanine across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904557 GO:1904556 biolink:BiologicalProcess L-tryptophan transmembrane transport The directed movement of L-tryptophan across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904556 GO:1904555 biolink:BiologicalProcess L-proline transmembrane transport The directed movement of L-proline across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904555 GO:1904554 biolink:BiologicalProcess positive regulation of chemotaxis to arachidonic acid Any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid. go.json activation of chemotaxis to arachidonic acid|up regulation of chemotaxis to arachidonic acid|up-regulation of chemotaxis to arachidonic acid|upregulation of chemotaxis to arachidonic acid http://purl.obolibrary.org/obo/GO_1904554 GO:1904553 biolink:BiologicalProcess negative regulation of chemotaxis to arachidonic acid Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid. go.json down regulation of chemotaxis to arachidonic acid|down-regulation of chemotaxis to arachidonic acid|downregulation of chemotaxis to arachidonic acid|inhibition of chemotaxis to arachidonic acid http://purl.obolibrary.org/obo/GO_1904553 GO:1904563 biolink:BiologicalProcess phosphatidylinositol 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate. go.json phosphatidylinositol 5-phosphate anabolism|phosphatidylinositol 5-phosphate biosynthesis|phosphatidylinositol 5-phosphate formation|phosphatidylinositol 5-phosphate synthesis http://purl.obolibrary.org/obo/GO_1904563 GO:1904562 biolink:BiologicalProcess phosphatidylinositol 5-phosphate metabolic process The chemical reactions and pathways involving phosphatidylinositol 5-phosphate. go.json phosphatidylinositol 5-phosphate metabolism http://purl.obolibrary.org/obo/GO_1904562 GO:1904561 biolink:BiologicalProcess cellular response to diphenidol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus. go.json http://purl.obolibrary.org/obo/GO_1904561 GO:1904560 biolink:BiologicalProcess response to diphenidol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus. go.json http://purl.obolibrary.org/obo/GO_1904560 GO:1904569 biolink:BiologicalProcess regulation of selenocysteine incorporation Any process that modulates the frequency, rate or extent of selenocysteine incorporation. go.json http://purl.obolibrary.org/obo/GO_1904569 GO:1904568 biolink:BiologicalProcess cellular response to wortmannin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus. go.json cellular response to wartmannin http://purl.obolibrary.org/obo/GO_1904568 GO:1904567 biolink:BiologicalProcess response to wortmannin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus. go.json response to wartmannin http://purl.obolibrary.org/obo/GO_1904567 GO:1904566 biolink:BiologicalProcess cellular response to 1-oleoyl-sn-glycerol 3-phosphate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus. go.json cellular response to 1-oleoyl lysophosphatidic acid|cellular response to LPA|cellular response to lysophosphatidic acid|cellular response to oleoyl lysophosphatidic acid|cellular response to oleoyl-L-alpha-lysophosphatidic acid http://purl.obolibrary.org/obo/GO_1904566 GO:1904565 biolink:BiologicalProcess response to 1-oleoyl-sn-glycerol 3-phosphate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus. go.json response to 1-oleoyl lysophosphatidic acid|response to LPA|response to lysophosphatidic acid|response to oleoyl lysophosphatidic acid|response to oleoyl-L-alpha-lysophosphatidic acid http://purl.obolibrary.org/obo/GO_1904565 GO:1904564 biolink:CellularComponent Nbp35-Cfd1 ATPase complex An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1. go.json http://purl.obolibrary.org/obo/GO_1904564 GO:1904574 biolink:BiologicalProcess negative regulation of selenocysteine insertion sequence binding Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding. go.json down regulation of SECIS binding|down regulation of selenocysteine insertion sequence binding|down-regulation of SECIS binding|down-regulation of selenocysteine insertion sequence binding|downregulation of SECIS binding|downregulation of selenocysteine insertion sequence binding|inhibition of SECIS binding|inhibition of selenocysteine insertion sequence binding|negative regulation of SECIS binding http://purl.obolibrary.org/obo/GO_1904574 gocheck_do_not_annotate GO:1904573 biolink:BiologicalProcess regulation of selenocysteine insertion sequence binding Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding. go.json regulation of SECIS binding http://purl.obolibrary.org/obo/GO_1904573 gocheck_do_not_annotate GO:1904572 biolink:BiologicalProcess negative regulation of mRNA binding Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding. go.json down regulation of mRNA binding|down-regulation of mRNA binding|downregulation of mRNA binding|inhibition of mRNA binding http://purl.obolibrary.org/obo/GO_1904572 gocheck_do_not_annotate GO:1904571 biolink:BiologicalProcess positive regulation of selenocysteine incorporation Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation. go.json activation of selenocysteine incorporation|up regulation of selenocysteine incorporation|up-regulation of selenocysteine incorporation|upregulation of selenocysteine incorporation http://purl.obolibrary.org/obo/GO_1904571 GO:1904570 biolink:BiologicalProcess negative regulation of selenocysteine incorporation Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation. go.json down regulation of selenocysteine incorporation|down-regulation of selenocysteine incorporation|downregulation of selenocysteine incorporation|inhibition of selenocysteine incorporation http://purl.obolibrary.org/obo/GO_1904570 GO:1904579 biolink:BiologicalProcess obsolete cellular response to thapsigargin OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904579 GO:0170022 biolink:MolecularActivity ionotropic bitter taste receptor activity Enables the transmembrane transfer of an ion by a channel that opens when a specific bitter compound has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0170022 GO:1904578 biolink:BiologicalProcess obsolete response to thapsigargin OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904578 GO:1904577 biolink:BiologicalProcess obsolete cellular response to tunicamycin OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904577 GO:0170021 biolink:MolecularActivity ionotropic taste receptor activity Enables the transmembrane transfer of an ion by a channel that opens when a soluble compound has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0170021 GO:0170020 biolink:MolecularActivity ionotropic olfactory receptor activity Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0170020 GO:1904576 biolink:BiologicalProcess obsolete response to tunicamycin OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904576 GO:1904575 biolink:BiologicalProcess positive regulation of selenocysteine insertion sequence binding Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding. go.json activation of SECIS binding|activation of selenocysteine insertion sequence binding|positive regulation of SECIS binding|up regulation of SECIS binding|up regulation of selenocysteine insertion sequence binding|up-regulation of SECIS binding|up-regulation of selenocysteine insertion sequence binding|upregulation of SECIS binding|upregulation of selenocysteine insertion sequence binding http://purl.obolibrary.org/obo/GO_1904575 gocheck_do_not_annotate GO:1904585 biolink:BiologicalProcess response to putrescine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus. go.json response to 1,4-Butanediamine|response to 1,4-Diaminobutane|response to tetramethylenediamine http://purl.obolibrary.org/obo/GO_1904585 GO:1904584 biolink:BiologicalProcess cellular response to polyamine macromolecule Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus. go.json cellular response to polyamine|cellular response to polyamines http://purl.obolibrary.org/obo/GO_1904584 GO:1904583 biolink:BiologicalProcess response to polyamine macromolecule Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus. go.json response to polyamine|response to polyamines http://purl.obolibrary.org/obo/GO_1904583 GO:1904582 biolink:BiologicalProcess positive regulation of intracellular mRNA localization Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization. go.json activation of establishment and maintenance of intracellular RNA localization|activation of intracellular mRNA localisation|activation of intracellular mRNA localization|activation of intracellular mRNA positioning|activation of mRNA localization, intracellular|activation of mRNA positioning, intracellular|positive regulation of establishment and maintenance of intracellular RNA localization|positive regulation of intracellular mRNA localisation|positive regulation of intracellular mRNA positioning|positive regulation of mRNA localization, intracellular|positive regulation of mRNA positioning, intracellular|up regulation of establishment and maintenance of intracellular RNA localization|up regulation of intracellular mRNA localisation|up regulation of intracellular mRNA localization|up regulation of intracellular mRNA positioning|up regulation of mRNA localization, intracellular|up regulation of mRNA positioning, intracellular|up-regulation of establishment and maintenance of intracellular RNA localization|up-regulation of intracellular mRNA localisation|up-regulation of intracellular mRNA localization|up-regulation of intracellular mRNA positioning|up-regulation of mRNA localization, intracellular|up-regulation of mRNA positioning, intracellular|upregulation of establishment and maintenance of intracellular RNA localization|upregulation of intracellular mRNA localisation|upregulation of intracellular mRNA localization|upregulation of intracellular mRNA positioning|upregulation of mRNA localization, intracellular|upregulation of mRNA positioning, intracellular http://purl.obolibrary.org/obo/GO_1904582 GO:0170023 biolink:MolecularActivity ionotropic sweet taste receptor activity Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0170023 GO:1904581 biolink:BiologicalProcess negative regulation of intracellular mRNA localization Any process that stops, prevents or reduces the frequency, rate or extent of intracellular mRNA localization. go.json down regulation of establishment and maintenance of intracellular RNA localization|down regulation of intracellular mRNA localisation|down regulation of intracellular mRNA localization|down regulation of intracellular mRNA positioning|down regulation of mRNA localization, intracellular|down regulation of mRNA positioning, intracellular|down-regulation of establishment and maintenance of intracellular RNA localization|down-regulation of intracellular mRNA localisation|down-regulation of intracellular mRNA localization|down-regulation of intracellular mRNA positioning|down-regulation of mRNA localization, intracellular|down-regulation of mRNA positioning, intracellular|downregulation of establishment and maintenance of intracellular RNA localization|downregulation of intracellular mRNA localisation|downregulation of intracellular mRNA localization|downregulation of intracellular mRNA positioning|downregulation of mRNA localization, intracellular|downregulation of mRNA positioning, intracellular|inhibition of establishment and maintenance of intracellular RNA localization|inhibition of intracellular mRNA localisation|inhibition of intracellular mRNA localization|inhibition of intracellular mRNA positioning|inhibition of mRNA localization, intracellular|inhibition of mRNA positioning, intracellular|negative regulation of establishment and maintenance of intracellular RNA localization|negative regulation of intracellular mRNA localisation|negative regulation of intracellular mRNA positioning|negative regulation of mRNA localization, intracellular|negative regulation of mRNA positioning, intracellular http://purl.obolibrary.org/obo/GO_1904581 GO:1904580 biolink:BiologicalProcess regulation of intracellular mRNA localization Any process that modulates the frequency, rate or extent of intracellular mRNA localization. go.json regulation of establishment and maintenance of intracellular RNA localization|regulation of intracellular mRNA localisation|regulation of intracellular mRNA positioning|regulation of mRNA localization, intracellular|regulation of mRNA positioning, intracellular http://purl.obolibrary.org/obo/GO_1904580 GO:0170027 biolink:CellularComponent SKA complex An outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis. In humans, it contains the subunits SKA1, SKA2 and SKA3. go.json SKA1 complex http://purl.obolibrary.org/obo/GO_0170027 GO:1904589 biolink:BiologicalProcess regulation of protein import Any process that modulates the frequency, rate or extent of protein import. go.json regulation of protein uptake http://purl.obolibrary.org/obo/GO_1904589 GO:0170011 biolink:MolecularActivity stalled ribosome sensor activity A molecule that recognizes stalled ribosomes and initiates a signaling response. go.json http://purl.obolibrary.org/obo/GO_0170011 GO:0170010 biolink:CellularComponent nonsense-mediated decay complex A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. IntAct:EBI-16420380 go.json Upf complex http://purl.obolibrary.org/obo/GO_0170010 GO:1904588 biolink:BiologicalProcess cellular response to glycoprotein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. go.json cellular response to glycoproteins http://purl.obolibrary.org/obo/GO_1904588 GO:1904587 biolink:BiologicalProcess response to glycoprotein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. go.json response to glycoproteins http://purl.obolibrary.org/obo/GO_1904587 GO:1904586 biolink:BiologicalProcess cellular response to putrescine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus. go.json cellular response to 1,4-Butanediamine|cellular response to 1,4-Diaminobutane|cellular response to tetramethylenediamine http://purl.obolibrary.org/obo/GO_1904586 GO:0170015 biolink:MolecularActivity carbon dioxide receptor activity Combining with carbon dioxide to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0170015 GO:1904596 biolink:BiologicalProcess regulation of connective tissue replacement involved in inflammatory response wound healing Any process that modulates the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response. go.json regulation of connective tissue replacement during inflammatory response|regulation of fibrosis during inflammatory response http://purl.obolibrary.org/obo/GO_1904596 GO:1904595 biolink:BiologicalProcess positive regulation of termination of RNA polymerase II transcription Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription. go.json activation of RNA 3'-end formation by RNA polymerase II|activation of RNA polymerase II transcription termination|activation of RNA polymerase II transcription termination factor activity|activation of termination of RNA polymerase II transcription|activation of transcription termination from Pol II promoter|activation of transcription termination from RNA polymerase II promoter|positive regulation of RNA 3'-end formation by RNA polymerase II|positive regulation of RNA polymerase II transcription termination|positive regulation of RNA polymerase II transcription termination factor activity|positive regulation of transcription termination from Pol II promoter|positive regulation of transcription termination from RNA polymerase II promoter|up regulation of RNA 3'-end formation by RNA polymerase II|up regulation of RNA polymerase II transcription termination|up regulation of RNA polymerase II transcription termination factor activity|up regulation of termination of RNA polymerase II transcription|up regulation of transcription termination from Pol II promoter|up regulation of transcription termination from RNA polymerase II promoter|up-regulation of RNA 3'-end formation by RNA polymerase II|up-regulation of RNA polymerase II transcription termination|up-regulation of RNA polymerase II transcription termination factor activity|up-regulation of termination of RNA polymerase II transcription|up-regulation of transcription termination from Pol II promoter|up-regulation of transcription termination from RNA polymerase II promoter|upregulation of RNA 3'-end formation by RNA polymerase II|upregulation of RNA polymerase II transcription termination|upregulation of RNA polymerase II transcription termination factor activity|upregulation of termination of RNA polymerase II transcription|upregulation of transcription termination from Pol II promoter|upregulation of transcription termination from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_1904595 GO:0170014 biolink:CellularComponent ankyrin-1 complex A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human. go.json ankyrin complex|erythrocyte ankyrin-1 complex http://purl.obolibrary.org/obo/GO_0170014 GO:0170013 biolink:CellularComponent channel complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. go.json http://purl.obolibrary.org/obo/GO_0170013 GO:1904594 biolink:BiologicalProcess regulation of termination of RNA polymerase II transcription Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription. go.json regulation of RNA 3'-end formation by RNA polymerase II|regulation of RNA polymerase II transcription termination|regulation of RNA polymerase II transcription termination factor activity|regulation of transcription termination from Pol II promoter|regulation of transcription termination from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_1904594 GO:1904593 biolink:MolecularActivity prostaglandin binding Binding to prostaglandin. go.json http://purl.obolibrary.org/obo/GO_1904593 GO:0170012 biolink:MolecularActivity histone H3K18 decrotonylase activity Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide. go.json http://purl.obolibrary.org/obo/GO_0170012 GO:1904592 biolink:BiologicalProcess positive regulation of protein refolding Any process that activates or increases the frequency, rate or extent of protein refolding. go.json activation of heat shock protein activity|activation of protein refolding|positive regulation of heat shock protein activity|up regulation of heat shock protein activity|up regulation of protein refolding|up-regulation of heat shock protein activity|up-regulation of protein refolding|upregulation of heat shock protein activity|upregulation of protein refolding http://purl.obolibrary.org/obo/GO_1904592 GO:1904591 biolink:BiologicalProcess positive regulation of protein import Any process that activates or increases the frequency, rate or extent of protein import. go.json activation of protein import|activation of protein uptake|positive regulation of protein uptake|up regulation of protein import|up regulation of protein uptake|up-regulation of protein import|up-regulation of protein uptake|upregulation of protein import|upregulation of protein uptake http://purl.obolibrary.org/obo/GO_1904591 GO:1904590 biolink:BiologicalProcess negative regulation of protein import Any process that stops, prevents or reduces the frequency, rate or extent of protein import. go.json down regulation of protein import|down regulation of protein uptake|down-regulation of protein import|down-regulation of protein uptake|downregulation of protein import|downregulation of protein uptake|inhibition of protein import|inhibition of protein uptake|negative regulation of protein uptake http://purl.obolibrary.org/obo/GO_1904590 GO:0170016 biolink:MolecularActivity endoplasmic reticulum-endosome tether activity The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange. go.json http://purl.obolibrary.org/obo/GO_0170016 GO:1904599 biolink:MolecularActivity advanced glycation end-product binding Binding to advanced glycation end-product. go.json http://purl.obolibrary.org/obo/GO_1904599 GO:1904598 biolink:BiologicalProcess positive regulation of connective tissue replacement involved in inflammatory response wound healing Any process that activates or increases the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response. go.json activation of connective tissue replacement during inflammatory response|activation of connective tissue replacement involved in inflammatory response wound healing|activation of fibrosis during inflammatory response|positive regulation of connective tissue replacement during inflammatory response|positive regulation of fibrosis during inflammatory response|up regulation of connective tissue replacement during inflammatory response|up regulation of connective tissue replacement involved in inflammatory response wound healing|up regulation of fibrosis during inflammatory response|up-regulation of connective tissue replacement during inflammatory response|up-regulation of connective tissue replacement involved in inflammatory response wound healing|up-regulation of fibrosis during inflammatory response|upregulation of connective tissue replacement during inflammatory response|upregulation of connective tissue replacement involved in inflammatory response wound healing|upregulation of fibrosis during inflammatory response http://purl.obolibrary.org/obo/GO_1904598 GO:1904597 biolink:BiologicalProcess negative regulation of connective tissue replacement involved in inflammatory response wound healing Any process that stops, prevents or reduces the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response. go.json down regulation of connective tissue replacement during inflammatory response|down regulation of connective tissue replacement involved in inflammatory response wound healing|down regulation of fibrosis during inflammatory response|down-regulation of connective tissue replacement during inflammatory response|down-regulation of connective tissue replacement involved in inflammatory response wound healing|down-regulation of fibrosis during inflammatory response|downregulation of connective tissue replacement during inflammatory response|downregulation of connective tissue replacement involved in inflammatory response wound healing|downregulation of fibrosis during inflammatory response|inhibition of connective tissue replacement during inflammatory response|inhibition of connective tissue replacement involved in inflammatory response wound healing|inhibition of fibrosis during inflammatory response|negative regulation of connective tissue replacement during inflammatory response|negative regulation of fibrosis during inflammatory response http://purl.obolibrary.org/obo/GO_1904597 GO:0170004 biolink:MolecularActivity lipoate transmembrane transporter activity Enables the transfer of lipoate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0170004 GO:0170003 biolink:MolecularActivity heme B transmembrane transporter activity Enables the transfer of heme B from one side of a membrane to the other. RHEA:75443 go.json http://purl.obolibrary.org/obo/GO_0170003 GO:0170002 biolink:BiologicalProcess halotropism A sodium-specific negative tropism that is crucial for surviving and thriving under high salinity. go.json root halotropism http://purl.obolibrary.org/obo/GO_0170002 GO:0170001 biolink:MolecularActivity ergothioneine transmembrane transporter activity Enables the transfer of ergothioneine from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0170001 GO:0170008 biolink:MolecularActivity mRNA phosphatase activator activity Binds to and increases the activity of mRNA phosphatase. go.json http://purl.obolibrary.org/obo/GO_0170008 GO:0170007 biolink:MolecularActivity endoplasmic reticulum-lipid droplet tether activity The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication. go.json http://purl.obolibrary.org/obo/GO_0170007 GO:0170006 biolink:BiologicalProcess lipoate transmembrane transport The process in which lipoate is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_0170006 GO:0170005 biolink:MolecularActivity cyclic nucleotide phosphodiesterase activator activity Binds to and increases the activity of cyclic nucleotide phosphodiesterase. go.json http://purl.obolibrary.org/obo/GO_0170005 GO:0170009 biolink:MolecularActivity endoplasmic reticulum-organelle membrane tether activity The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain membrane contact sites and mediate organelle exchange and communication. go.json http://purl.obolibrary.org/obo/GO_0170009 GO:1904509 biolink:BiologicalProcess negative regulation of protein localization to basolateral plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to basolateral plasma membrane. go.json down regulation of protein localisation in basolateral plasma membrane|down regulation of protein localisation to basolateral plasma membrane|down regulation of protein localization in basolateral plasma membrane|down regulation of protein localization to basolateral plasma membrane|down-regulation of protein localisation in basolateral plasma membrane|down-regulation of protein localisation to basolateral plasma membrane|down-regulation of protein localization in basolateral plasma membrane|down-regulation of protein localization to basolateral plasma membrane|downregulation of protein localisation in basolateral plasma membrane|downregulation of protein localisation to basolateral plasma membrane|downregulation of protein localization in basolateral plasma membrane|downregulation of protein localization to basolateral plasma membrane|inhibition of protein localisation in basolateral plasma membrane|inhibition of protein localisation to basolateral plasma membrane|inhibition of protein localization in basolateral plasma membrane|inhibition of protein localization to basolateral plasma membrane|negative regulation of protein localisation in basolateral plasma membrane|negative regulation of protein localisation to basolateral plasma membrane|negative regulation of protein localization in basolateral plasma membrane http://purl.obolibrary.org/obo/GO_1904509 GO:1904508 biolink:BiologicalProcess regulation of protein localization to basolateral plasma membrane Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane. go.json regulation of protein localisation in basolateral plasma membrane|regulation of protein localisation to basolateral plasma membrane|regulation of protein localization in basolateral plasma membrane http://purl.obolibrary.org/obo/GO_1904508 GO:1904507 biolink:BiologicalProcess positive regulation of telomere maintenance in response to DNA damage Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage. go.json activation of DNA damage response, telomere maintenance|activation of telomere maintenance in response to DNA damage|positive regulation of DNA damage response, telomere maintenance|up regulation of DNA damage response, telomere maintenance|up regulation of telomere maintenance in response to DNA damage|up-regulation of DNA damage response, telomere maintenance|up-regulation of telomere maintenance in response to DNA damage|upregulation of DNA damage response, telomere maintenance|upregulation of telomere maintenance in response to DNA damage http://purl.obolibrary.org/obo/GO_1904507 GO:1904506 biolink:BiologicalProcess negative regulation of telomere maintenance in response to DNA damage Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage. go.json down regulation of DNA damage response, telomere maintenance|down regulation of telomere maintenance in response to DNA damage|down-regulation of DNA damage response, telomere maintenance|down-regulation of telomere maintenance in response to DNA damage|downregulation of DNA damage response, telomere maintenance|downregulation of telomere maintenance in response to DNA damage|inhibition of DNA damage response, telomere maintenance|inhibition of telomere maintenance in response to DNA damage|negative regulation of DNA damage response, telomere maintenance http://purl.obolibrary.org/obo/GO_1904506 GO:1904505 biolink:BiologicalProcess regulation of telomere maintenance in response to DNA damage Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage. go.json regulation of DNA damage response, telomere maintenance http://purl.obolibrary.org/obo/GO_1904505 GO:1904504 biolink:BiologicalProcess positive regulation of lipophagy Any process that activates or increases the frequency, rate or extent of lipophagy. go.json activation of lipophagy|up regulation of lipophagy|up-regulation of lipophagy|upregulation of lipophagy http://purl.obolibrary.org/obo/GO_1904504 GO:1904503 biolink:BiologicalProcess negative regulation of lipophagy Any process that stops, prevents or reduces the frequency, rate or extent of lipophagy. go.json down regulation of lipophagy|down-regulation of lipophagy|downregulation of lipophagy|inhibition of lipophagy http://purl.obolibrary.org/obo/GO_1904503 GO:1904502 biolink:BiologicalProcess regulation of lipophagy Any process that modulates the frequency, rate or extent of lipophagy. go.json http://purl.obolibrary.org/obo/GO_1904502 GO:1904501 biolink:BiologicalProcess obsolete positive regulation of chromatin-mediated maintenance of transcription OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin-mediated maintenance of transcription. go.json activation of chromatin-mediated maintenance of transcription|up regulation of chromatin-mediated maintenance of transcription|up-regulation of chromatin-mediated maintenance of transcription|upregulation of chromatin-mediated maintenance of transcription True http://purl.obolibrary.org/obo/GO_1904501 GO:1904500 biolink:BiologicalProcess obsolete negative regulation of chromatin-mediated maintenance of transcription OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of chromatin-mediated maintenance of transcription. go.json down regulation of chromatin-mediated maintenance of transcription|down-regulation of chromatin-mediated maintenance of transcription|downregulation of chromatin-mediated maintenance of transcription|inhibition of chromatin-mediated maintenance of transcription True http://purl.obolibrary.org/obo/GO_1904500 GO:0003997 biolink:MolecularActivity acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. EC:1.3.3.6|MetaCyc:RXN-11026|RHEA:38959|Reactome:R-HSA-192335|Reactome:R-HSA-193369|Reactome:R-HSA-2066787|Reactome:R-HSA-390256 go.json acyl coenzyme A oxidase activity|acyl-CoA:oxygen 2-oxidoreductase activity|fatty acyl-CoA oxidase activity|fatty acyl-coenzyme A oxidase activity http://purl.obolibrary.org/obo/GO_0003997 GO:0003996 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003996 GO:0003999 biolink:MolecularActivity adenine phosphoribosyltransferase activity Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. EC:2.4.2.7|MetaCyc:ADENPRIBOSYLTRAN-RXN|RHEA:16609|Reactome:R-HSA-74213|Reactome:R-HSA-9734193 go.json AMP diphosphorylase activity|AMP pyrophosphorylase activity|AMP-pyrophosphate phosphoribosyltransferase activity|AMP:diphosphate phospho-D-ribosyltransferase activity|APRT activity|adenine phosphoribosylpyrophosphate transferase activity|adenosine phosphoribosyltransferase activity|adenylate pyrophosphorylase activity|adenylic pyrophosphorylase activity|transphosphoribosidase activity http://purl.obolibrary.org/obo/GO_0003999 GO:0003998 biolink:MolecularActivity acylphosphatase activity Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. EC:3.6.1.7|MetaCyc:ACYLPHOSPHATASE-RXN|RHEA:14965 go.json 1,3-diphosphoglycerate phosphatase activity|GP 1-3|Ho 1-3|acetic phosphatase activity|acetylphosphatase activity|acylphosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0003998 GO:0003993 biolink:MolecularActivity acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. EC:3.1.3.2|MetaCyc:ACID-PHOSPHATASE-RXN|Reactome:R-HSA-196950 go.json acid monophosphatase activity|acid nucleoside diphosphate phosphatase activity|acid phosphohydrolase activity|acid phosphomonoester hydrolase activity|acid phosphomonoesterase activity|glycerophosphatase activity|orthophosphoric-monoester phosphohydrolase (acid optimum)|phosphate-monoester phosphohydrolase (acid optimum)|phosphomonoesterase activity|uteroferrin http://purl.obolibrary.org/obo/GO_0003993 GO:0003992 biolink:MolecularActivity N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. EC:2.6.1.11|KEGG_REACTION:R02283|MetaCyc:ACETYLORNTRANSAM-RXN|RHEA:18049 go.json 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity|ACOAT activity|N(2)-acetylornithine 5-transaminase activity|N-acetylornithine aminotransferase activity|N-acetylornithine-delta-transaminase activity|N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity|N2-acetylornithine 5-aminotransferase activity|N2-acetylornithine 5-transaminase activity|acetylornithine 5-aminotransferase activity|acetylornithine aminotransferase activity|acetylornithine delta-transaminase activity|acetylornithine transaminase activity|succinylornithine aminotransferase activity http://purl.obolibrary.org/obo/GO_0003992 GO:1904519 biolink:BiologicalProcess protein localization to microtubule minus-end A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end. go.json protein localisation in microtubule minus-end|protein localisation to microtubule minus-end|protein localization in microtubule minus-end http://purl.obolibrary.org/obo/GO_1904519 GO:0003995 biolink:MolecularActivity acyl-CoA dehydrogenase activity Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. MetaCyc:ACYLCOADEHYDROG-RXN|RHEA:44704|Reactome:R-HSA-109341|Reactome:R-HSA-5695980|Reactome:R-HSA-5695989|Reactome:R-HSA-70800|Reactome:R-HSA-70859|Reactome:R-HSA-77263|Reactome:R-HSA-77274|Reactome:R-HSA-77299|Reactome:R-HSA-77319|Reactome:R-HSA-77327|Reactome:R-HSA-77338|Reactome:R-HSA-77345 go.json acyl CoA dehydrogenase activity|acyl coenzyme A dehydrogenase activity|acyl-CoA reductase activity|fatty acyl coenzyme A dehydrogenase activity|fatty-acyl-CoA dehydrogenase activity|general acyl CoA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003995 GO:1904518 biolink:BiologicalProcess protein localization to cytoplasmic microtubule plus-end A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end. go.json protein localisation in cytoplasmic microtubule plus-end|protein localisation to cytoplasmic microtubule plus-end|protein localization in cytoplasmic microtubule plus-end http://purl.obolibrary.org/obo/GO_1904518 GO:1904517 biolink:MolecularActivity obsolete MgATP(2-) binding OBSOLETE. Binding to MgATP(2-). go.json True http://purl.obolibrary.org/obo/GO_1904517 GO:0003994 biolink:MolecularActivity aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. EC:4.2.1.3|MetaCyc:RXN-14047|RHEA:10336|Reactome:R-HSA-450975|Reactome:R-HSA-5690911|Reactome:R-HSA-70971 go.json aconitase activity|cis-aconitase activity|citrate hydro-lyase activity|citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|citrate(isocitrate) hydro-lyase activity http://purl.obolibrary.org/obo/GO_0003994 GO:1904516 biolink:BiologicalProcess myofibroblast cell apoptotic process Any apoptotic process in a myofibroblast cell. go.json MFB apoptosis|MFB apoptotic process|myofibroblast cell apoptosis http://purl.obolibrary.org/obo/GO_1904516 GO:1904515 biolink:BiologicalProcess positive regulation of TORC2 signaling Any process that activates or increases the frequency, rate or extent of TORC2 signaling. go.json activation of TORC2 signal transduction|activation of TORC2 signaling|positive regulation of TORC2 signal transduction|up regulation of TORC2 signal transduction|up regulation of TORC2 signaling|up-regulation of TORC2 signal transduction|up-regulation of TORC2 signaling|upregulation of TORC2 signal transduction|upregulation of TORC2 signaling http://purl.obolibrary.org/obo/GO_1904515 GO:1904514 biolink:BiologicalProcess positive regulation of initiation of premeiotic DNA replication Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication. go.json activation of initiation of meiotic DNA synthesis|activation of initiation of premeiotic DNA replication|activation of initiation of premeiotic DNA synthesis|activation of meiotic DNA replication initiation|activation of premeiotic DNA replication initiation|positive regulation of initiation of meiotic DNA synthesis|positive regulation of initiation of premeiotic DNA synthesis|positive regulation of meiotic DNA replication initiation|positive regulation of premeiotic DNA replication initiation|up regulation of initiation of meiotic DNA synthesis|up regulation of initiation of premeiotic DNA replication|up regulation of initiation of premeiotic DNA synthesis|up regulation of meiotic DNA replication initiation|up regulation of premeiotic DNA replication initiation|up-regulation of initiation of meiotic DNA synthesis|up-regulation of initiation of premeiotic DNA replication|up-regulation of initiation of premeiotic DNA synthesis|up-regulation of meiotic DNA replication initiation|up-regulation of premeiotic DNA replication initiation|upregulation of initiation of meiotic DNA synthesis|upregulation of initiation of premeiotic DNA replication|upregulation of initiation of premeiotic DNA synthesis|upregulation of meiotic DNA replication initiation|upregulation of premeiotic DNA replication initiation http://purl.obolibrary.org/obo/GO_1904514 GO:0003991 biolink:MolecularActivity acetylglutamate kinase activity Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. EC:2.7.2.8|MetaCyc:ACETYLGLUTKIN-RXN|RHEA:14629 go.json ATP:N-acetyl-L-glutamate 5-phosphotransferase activity|N-acetylglutamate 5-phosphotransferase activity|N-acetylglutamate kinase activity|N-acetylglutamate phosphokinase activity|N-acetylglutamic 5-phosphotransferase activity|acetylglutamate phosphokinase activity http://purl.obolibrary.org/obo/GO_0003991 GO:1904513 biolink:BiologicalProcess negative regulation of initiation of premeiotic DNA replication Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication. go.json down regulation of initiation of meiotic DNA synthesis|down regulation of initiation of premeiotic DNA replication|down regulation of initiation of premeiotic DNA synthesis|down regulation of meiotic DNA replication initiation|down regulation of premeiotic DNA replication initiation|down-regulation of initiation of meiotic DNA synthesis|down-regulation of initiation of premeiotic DNA replication|down-regulation of initiation of premeiotic DNA synthesis|down-regulation of meiotic DNA replication initiation|down-regulation of premeiotic DNA replication initiation|downregulation of initiation of meiotic DNA synthesis|downregulation of initiation of premeiotic DNA replication|downregulation of initiation of premeiotic DNA synthesis|downregulation of meiotic DNA replication initiation|downregulation of premeiotic DNA replication initiation|inhibition of initiation of meiotic DNA synthesis|inhibition of initiation of premeiotic DNA replication|inhibition of initiation of premeiotic DNA synthesis|inhibition of meiotic DNA replication initiation|inhibition of premeiotic DNA replication initiation|negative regulation of initiation of meiotic DNA synthesis|negative regulation of initiation of premeiotic DNA synthesis|negative regulation of meiotic DNA replication initiation|negative regulation of premeiotic DNA replication initiation http://purl.obolibrary.org/obo/GO_1904513 GO:0003990 biolink:MolecularActivity acetylcholinesterase activity Catalysis of the reaction: acetylcholine + H2O = choline + acetate. EC:3.1.1.7|MetaCyc:ACETYLCHOLINESTERASE-RXN|RHEA:17561|Reactome:R-HSA-372519 go.json AcCholE|acetyl.beta-methylcholinesterase activity|acetylcholine acetylhydrolase activity|acetylcholine hydrolase activity|acetylthiocholinesterase activity|choline esterase I activity|true cholinesterase activity http://purl.obolibrary.org/obo/GO_0003990 goslim_chembl GO:1904512 biolink:BiologicalProcess regulation of initiation of premeiotic DNA replication Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication. go.json regulation of initiation of meiotic DNA synthesis|regulation of initiation of premeiotic DNA synthesis|regulation of meiotic DNA replication initiation|regulation of premeiotic DNA replication initiation http://purl.obolibrary.org/obo/GO_1904512 GO:1904511 biolink:CellularComponent cytoplasmic microtubule plus-end Any microtubule plus-end that is part of a cytoplasmic microtubule. go.json growing microtubule plus end of cytoplasmic microtubule|growing microtubule plus end of non-spindle-associated astral microtubule|microtubule plus end of cytoplasmic microtubule|microtubule plus end of non-spindle-associated astral microtubule|microtubule plus-end of cytoplasmic microtubule|microtubule plus-end of non-spindle-associated astral microtubule http://purl.obolibrary.org/obo/GO_1904511 GO:1904510 biolink:BiologicalProcess positive regulation of protein localization to basolateral plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to basolateral plasma membrane. go.json activation of protein localisation in basolateral plasma membrane|activation of protein localisation to basolateral plasma membrane|activation of protein localization in basolateral plasma membrane|activation of protein localization to basolateral plasma membrane|positive regulation of protein localisation in basolateral plasma membrane|positive regulation of protein localisation to basolateral plasma membrane|positive regulation of protein localization in basolateral plasma membrane|up regulation of protein localisation in basolateral plasma membrane|up regulation of protein localisation to basolateral plasma membrane|up regulation of protein localization in basolateral plasma membrane|up regulation of protein localization to basolateral plasma membrane|up-regulation of protein localisation in basolateral plasma membrane|up-regulation of protein localisation to basolateral plasma membrane|up-regulation of protein localization in basolateral plasma membrane|up-regulation of protein localization to basolateral plasma membrane|upregulation of protein localisation in basolateral plasma membrane|upregulation of protein localisation to basolateral plasma membrane|upregulation of protein localization in basolateral plasma membrane|upregulation of protein localization to basolateral plasma membrane http://purl.obolibrary.org/obo/GO_1904510 GO:1904529 biolink:BiologicalProcess regulation of actin filament binding Any process that modulates the frequency, rate or extent of actin filament binding. go.json regulation of F-actin binding|regulation of actin cross-linking activity http://purl.obolibrary.org/obo/GO_1904529 gocheck_do_not_annotate GO:1904528 biolink:BiologicalProcess positive regulation of microtubule binding Any process that activates or increases the frequency, rate or extent of microtubule binding. go.json activation of microtubule binding|activation of microtubule severing activity|activation of microtubule/chromatin interaction|positive regulation of microtubule severing activity|positive regulation of microtubule/chromatin interaction|up regulation of microtubule binding|up regulation of microtubule severing activity|up regulation of microtubule/chromatin interaction|up-regulation of microtubule binding|up-regulation of microtubule severing activity|up-regulation of microtubule/chromatin interaction|upregulation of microtubule binding|upregulation of microtubule severing activity|upregulation of microtubule/chromatin interaction http://purl.obolibrary.org/obo/GO_1904528 gocheck_do_not_annotate GO:1904527 biolink:BiologicalProcess negative regulation of microtubule binding Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding. go.json down regulation of microtubule binding|down regulation of microtubule severing activity|down regulation of microtubule/chromatin interaction|down-regulation of microtubule binding|down-regulation of microtubule severing activity|down-regulation of microtubule/chromatin interaction|downregulation of microtubule binding|downregulation of microtubule severing activity|downregulation of microtubule/chromatin interaction|inhibition of microtubule binding|inhibition of microtubule severing activity|inhibition of microtubule/chromatin interaction|negative regulation of microtubule severing activity|negative regulation of microtubule/chromatin interaction http://purl.obolibrary.org/obo/GO_1904527 gocheck_do_not_annotate GO:1904526 biolink:BiologicalProcess regulation of microtubule binding Any process that modulates the frequency, rate or extent of microtubule binding. go.json regulation of microtubule severing activity|regulation of microtubule/chromatin interaction http://purl.obolibrary.org/obo/GO_1904526 gocheck_do_not_annotate GO:1904525 biolink:BiologicalProcess positive regulation of DNA amplification Any process that activates or increases the frequency, rate or extent of DNA amplification. go.json activation of DNA amplification|up regulation of DNA amplification|up-regulation of DNA amplification|upregulation of DNA amplification http://purl.obolibrary.org/obo/GO_1904525 GO:1904524 biolink:BiologicalProcess negative regulation of DNA amplification Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification. go.json down regulation of DNA amplification|down-regulation of DNA amplification|downregulation of DNA amplification|inhibition of DNA amplification http://purl.obolibrary.org/obo/GO_1904524 GO:1904523 biolink:BiologicalProcess regulation of DNA amplification Any process that modulates the frequency, rate or extent of DNA amplification. go.json http://purl.obolibrary.org/obo/GO_1904523 GO:1904522 biolink:BiologicalProcess positive regulation of myofibroblast cell apoptotic process Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process. go.json activation of MFB apoptosis|activation of MFB apoptotic process|activation of myofibroblast cell apoptosis|activation of myofibroblast cell apoptotic process|positive regulation of MFB apoptosis|positive regulation of MFB apoptotic process|positive regulation of myofibroblast cell apoptosis|up regulation of MFB apoptosis|up regulation of MFB apoptotic process|up regulation of myofibroblast cell apoptosis|up regulation of myofibroblast cell apoptotic process|up-regulation of MFB apoptosis|up-regulation of MFB apoptotic process|up-regulation of myofibroblast cell apoptosis|up-regulation of myofibroblast cell apoptotic process|upregulation of MFB apoptosis|upregulation of MFB apoptotic process|upregulation of myofibroblast cell apoptosis|upregulation of myofibroblast cell apoptotic process http://purl.obolibrary.org/obo/GO_1904522 GO:1904521 biolink:BiologicalProcess negative regulation of myofibroblast cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process. go.json down regulation of MFB apoptosis|down regulation of MFB apoptotic process|down regulation of myofibroblast cell apoptosis|down regulation of myofibroblast cell apoptotic process|down-regulation of MFB apoptosis|down-regulation of MFB apoptotic process|down-regulation of myofibroblast cell apoptosis|down-regulation of myofibroblast cell apoptotic process|downregulation of MFB apoptosis|downregulation of MFB apoptotic process|downregulation of myofibroblast cell apoptosis|downregulation of myofibroblast cell apoptotic process|inhibition of MFB apoptosis|inhibition of MFB apoptotic process|inhibition of myofibroblast cell apoptosis|inhibition of myofibroblast cell apoptotic process|negative regulation of MFB apoptosis|negative regulation of MFB apoptotic process|negative regulation of myofibroblast cell apoptosis http://purl.obolibrary.org/obo/GO_1904521 GO:1904520 biolink:BiologicalProcess regulation of myofibroblast cell apoptotic process Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process. go.json regulation of MFB apoptosis|regulation of MFB apoptotic process|regulation of myofibroblast cell apoptosis http://purl.obolibrary.org/obo/GO_1904520 GO:1904530 biolink:BiologicalProcess negative regulation of actin filament binding Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding. go.json down regulation of F-actin binding|down regulation of actin cross-linking activity|down regulation of actin filament binding|down-regulation of F-actin binding|down-regulation of actin cross-linking activity|down-regulation of actin filament binding|downregulation of F-actin binding|downregulation of actin cross-linking activity|downregulation of actin filament binding|inhibition of F-actin binding|inhibition of actin cross-linking activity|inhibition of actin filament binding|negative regulation of F-actin binding|negative regulation of actin cross-linking activity http://purl.obolibrary.org/obo/GO_1904530 gocheck_do_not_annotate GO:0003975 biolink:MolecularActivity UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. EC:2.7.8.15|MetaCyc:2.7.8.15-RXN|RHEA:13289|Reactome:R-HSA-446191|Reactome:R-HSA-4549334 go.json GlcNAc-1-P transferase activity|N-acetylglucosamine-1-phosphate transferase activity|UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity|UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity|UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity|UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity|UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity|UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity|chitobiosylpyrophosphoryldolichol synthase activity|dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity|uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0003975 GO:0003974 biolink:MolecularActivity UDP-N-acetylglucosamine 4-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. EC:5.1.3.7|MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN|RHEA:20517 go.json UDP acetylglucosamine epimerase activity|UDP-GlcNAc 4-epimerase activity|UDP-N-acetyl-D-glucosamine 4-epimerase activity|uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity|uridine diphosphate N-acetylglucosamine-4-epimerase activity|uridine diphosphoacetylglucosamine epimerase activity http://purl.obolibrary.org/obo/GO_0003974 GO:0003977 biolink:MolecularActivity UDP-N-acetylglucosamine diphosphorylase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. EC:2.7.7.23|KEGG_REACTION:R00416|MetaCyc:NAG1P-URIDYLTRANS-RXN|RHEA:13509|Reactome:R-HSA-446204 go.json GlmU uridylyltransferase activity|N-acetylglucosamine-1-phosphate uridyltransferase activity|UDP-GlcNAc pyrophosphorylase activity|UDP-N-acetylglucosamine pyrophosphorylase activity|UDP-acetylglucosamine pyrophosphorylase activity|UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity|UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity|acetylglucosamine 1-phosphate uridylyltransferase|uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity|uridine diphosphoacetylglucosamine phosphorylase activity|uridine diphosphoacetylglucosamine pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0003977 GO:0003976 biolink:MolecularActivity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. EC:2.7.8.17|MetaCyc:2.7.8.17-RXN|RHEA:13581 go.json N-acetylglucosaminyl phosphotransferase activity|N-acetylglucosaminylphosphotransferase activity|UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity|UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity|UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity|UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity|lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0003976 GO:0003971 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003971 GO:0003973 biolink:MolecularActivity (S)-2-hydroxy-acid oxidase activity Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. EC:1.1.3.15|MetaCyc:RXN-969|MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN|RHEA:16789|Reactome:R-HSA-389842|Reactome:R-HSA-6787811 go.json L-2-hydroxy acid oxidase|L-alpha-hydroxy acid oxidase|glycolate oxidase activity|hydroxy-acid oxidase A activity|hydroxy-acid oxidase B activity|hydroxyacid oxidase A|long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity|medium-chain-(S)-2-hydroxy-acid oxidase activity|very-long-chain-(S)-2-hydroxy-acid oxidase activity http://purl.obolibrary.org/obo/GO_0003973 GO:0003972 biolink:MolecularActivity RNA ligase (ATP) activity Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). EC:6.5.1.3|MetaCyc:RNA-LIGASE-ATP-RXN|Reactome:R-HSA-5696816 go.json poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)|polyribonucleotide ligase activity|polyribonucleotide synthase (ATP) activity|ribonucleic ligase activity http://purl.obolibrary.org/obo/GO_0003972 GO:1904539 biolink:BiologicalProcess negative regulation of glycolytic process through fructose-6-phosphate Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate. go.json down regulation of glycolysis through fructose-6-phosphate|down regulation of glycolytic process through fructose-6-phosphate|down-regulation of glycolysis through fructose-6-phosphate|down-regulation of glycolytic process through fructose-6-phosphate|downregulation of glycolysis through fructose-6-phosphate|downregulation of glycolytic process through fructose-6-phosphate|inhibition of glycolysis through fructose-6-phosphate|inhibition of glycolytic process through fructose-6-phosphate|negative regulation of glycolysis through fructose-6-phosphate http://purl.obolibrary.org/obo/GO_1904539 GO:1904538 biolink:BiologicalProcess regulation of glycolytic process through fructose-6-phosphate Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate. go.json regulation of glycolysis through fructose-6-phosphate http://purl.obolibrary.org/obo/GO_1904538 GO:1904537 biolink:BiologicalProcess negative regulation of mitotic telomere tethering at nuclear periphery Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery. go.json down regulation of mitotic telomere tethering at nuclear periphery|down-regulation of mitotic telomere tethering at nuclear periphery|downregulation of mitotic telomere tethering at nuclear periphery|inhibition of mitotic telomere tethering at nuclear periphery http://purl.obolibrary.org/obo/GO_1904537 GO:1904536 biolink:BiologicalProcess regulation of mitotic telomere tethering at nuclear periphery Any process that modulates the frequency, rate or extent of mitotic telomere tethering at nuclear periphery. go.json http://purl.obolibrary.org/obo/GO_1904536 GO:1904535 biolink:BiologicalProcess positive regulation of telomeric loop disassembly Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly. go.json activation of T loop disassembly|activation of telomeric loop disassembly|positive regulation of T loop disassembly|up regulation of T loop disassembly|up regulation of telomeric loop disassembly|up-regulation of T loop disassembly|up-regulation of telomeric loop disassembly|upregulation of T loop disassembly|upregulation of telomeric loop disassembly http://purl.obolibrary.org/obo/GO_1904535 GO:1904534 biolink:BiologicalProcess negative regulation of telomeric loop disassembly Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly. go.json down regulation of T loop disassembly|down regulation of telomeric loop disassembly|down-regulation of T loop disassembly|down-regulation of telomeric loop disassembly|downregulation of T loop disassembly|downregulation of telomeric loop disassembly|inhibition of T loop disassembly|inhibition of telomeric loop disassembly|negative regulation of T loop disassembly http://purl.obolibrary.org/obo/GO_1904534 GO:1904533 biolink:BiologicalProcess regulation of telomeric loop disassembly Any process that modulates the frequency, rate or extent of telomeric loop disassembly. go.json regulation of T loop disassembly http://purl.obolibrary.org/obo/GO_1904533 GO:1904532 biolink:MolecularActivity obsolete ATP-dependent microtubule motor activity, minus-end-directed involved in microtubule-based movement OBSOLETE. Any ATP-dependent microtubule motor activity, minus-end-directed that is involved in microtubule-based movement. go.json True http://purl.obolibrary.org/obo/GO_1904532 GO:1904531 biolink:BiologicalProcess positive regulation of actin filament binding Any process that activates or increases the frequency, rate or extent of actin filament binding. go.json activation of F-actin binding|activation of actin cross-linking activity|activation of actin filament binding|positive regulation of F-actin binding|positive regulation of actin cross-linking activity|up regulation of F-actin binding|up regulation of actin cross-linking activity|up regulation of actin filament binding|up-regulation of F-actin binding|up-regulation of actin cross-linking activity|up-regulation of actin filament binding|upregulation of F-actin binding|upregulation of actin cross-linking activity|upregulation of actin filament binding http://purl.obolibrary.org/obo/GO_1904531 gocheck_do_not_annotate GO:1904541 biolink:BiologicalProcess fungal-type cell wall disassembly involved in conjugation with cellular fusion Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion. go.json fungal-type cell wall disassembly involved in cell fusion|fungal-type cell wall disassembly involved in mating http://purl.obolibrary.org/obo/GO_1904541 GO:1904540 biolink:BiologicalProcess positive regulation of glycolytic process through fructose-6-phosphate Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate. go.json activation of glycolysis through fructose-6-phosphate|activation of glycolytic process through fructose-6-phosphate|positive regulation of glycolysis through fructose-6-phosphate|up regulation of glycolysis through fructose-6-phosphate|up regulation of glycolytic process through fructose-6-phosphate|up-regulation of glycolysis through fructose-6-phosphate|up-regulation of glycolytic process through fructose-6-phosphate|upregulation of glycolysis through fructose-6-phosphate|upregulation of glycolytic process through fructose-6-phosphate http://purl.obolibrary.org/obo/GO_1904540 GO:0003979 biolink:MolecularActivity UDP-glucose 6-dehydrogenase activity Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate. EC:1.1.1.22|KEGG_REACTION:R00286|MetaCyc:UGD-RXN|RHEA:23596|Reactome:R-HSA-173597 go.json http://purl.obolibrary.org/obo/GO_0003979 GO:0003978 biolink:MolecularActivity UDP-glucose 4-epimerase activity Catalysis of the reaction: UDP-glucose = UDP-galactose. EC:5.1.3.2|MetaCyc:UDPGLUCEPIM-RXN|RHEA:22168|Reactome:R-HSA-5610036|Reactome:R-HSA-70369 go.json 4-epimerase activity|UDP-D-galactose 4-epimerase activity|UDP-galactose 4-epimerase activity|UDP-glucose epimerase activity|UDPG-4-epimerase activity|UDPgalactose 4-epimerase activity|UDPglucose 4-epimerase activity|galactowaldenase activity|uridine diphosphate galactose 4-epimerase activity|uridine diphosphate glucose 4-epimerase activity|uridine diphospho-galactose-4-epimerase activity|uridine diphosphoglucose 4-epimerase activity|uridine diphosphoglucose epimerase activity http://purl.obolibrary.org/obo/GO_0003978 GO:0003986 biolink:MolecularActivity acetyl-CoA hydrolase activity Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+. EC:3.1.2.1|KEGG_REACTION:R00227|MetaCyc:ACETYL-COA-HYDROLASE-RXN|RHEA:20289|Reactome:R-HSA-2066779|Reactome:R-HSA-390304 go.json acetyl coenzyme A acylase activity|acetyl coenzyme A deacylase activity|acetyl coenzyme A hydrolase activity|acetyl-CoA acylase activity|acetyl-CoA deacylase activity|acetyl-CoA thiol esterase activity http://purl.obolibrary.org/obo/GO_0003986 GO:0003985 biolink:MolecularActivity acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. EC:2.3.1.9|MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN|RHEA:21036|Reactome:R-HSA-70844|Reactome:R-HSA-73916|Reactome:R-HSA-74181|Reactome:R-HSA-8848215|UM-BBD_enzymeID:e0144 go.json acetoacetyl-CoA thiolase activity|acetyl coenzyme A thiolase activity http://purl.obolibrary.org/obo/GO_0003985 GO:0003988 biolink:MolecularActivity acetyl-CoA C-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. EC:2.3.1.16|MetaCyc:KETOACYLCOATHIOL-RXN|RHEA:21564|Reactome:R-HSA-390250|Reactome:R-HSA-77271|Reactome:R-HSA-77304|Reactome:R-HSA-77309|Reactome:R-HSA-77321|Reactome:R-HSA-77329|Reactome:R-HSA-77340|Reactome:R-HSA-8874745|UM-BBD_reactionID:r1051 go.json 2-keto-acyl thiolase activity|3-ketoacyl coenzyme A thiolase activity|3-ketoacyl-CoA thiolase activity|3-ketothiolase activity|acetoacetyl-CoA beta-ketothiolase activity|acetyl-CoA acyltransferase activity|beta-ketoacyl coenzyme A thiolase activity|beta-ketothiolase activity http://purl.obolibrary.org/obo/GO_0003988 GO:0003987 biolink:MolecularActivity acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. EC:6.2.1.1|MetaCyc:ACETATE--COA-LIGASE-RXN|RHEA:23176|Reactome:R-HSA-449911|Reactome:R-HSA-71735|Reactome:R-HSA-8875071 go.json ACS|acetate thiokinase activity|acetate to acetyl-CoA|acetate:CoA ligase (AMP-forming)|acetic thiokinase activity|acetyl CoA ligase activity|acetyl CoA synthase activity|acetyl activating enzyme|acetyl coenzyme A synthetase activity|acetyl-CoA synthase activity|acetyl-CoA synthetase activity|acetyl-activating enzyme activity|acetyl-coenzyme A synthase activity|acyl-activating enzyme activity|short chain fatty acyl-CoA synthetase activity|short-chain acyl-coenzyme A synthetase activity http://purl.obolibrary.org/obo/GO_0003987 GO:0003982 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003982 GO:0003981 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003981 GO:0003984 biolink:MolecularActivity acetolactate synthase activity Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. EC:2.2.1.6|MetaCyc:ACETOLACTSYN-RXN|RHEA:25249 go.json acetohydroxy acid synthetase activity|acetohydroxyacid synthase activity|acetolactate pyruvate-lyase (carboxylating) activity|acetolactic synthetase activity|alpha-acetohydroxy acid synthetase activity|alpha-acetohydroxyacid synthase activity|alpha-acetolactate synthase activity|alpha-acetolactate synthetase activity|pyruvate:pyruvate acetaldehydetransferase (decarboxylating) http://purl.obolibrary.org/obo/GO_0003984 GO:0003983 biolink:MolecularActivity UTP:glucose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. EC:2.7.7.9|KEGG_REACTION:R00289|MetaCyc:GLUC1PURIDYLTRANS-RXN|RHEA:19889|Reactome:R-HSA-70286 go.json UDP glucose pyrophosphorylase activity|UDP-glucose diphosphorylase activity|UDP-glucose pyrophosphorylase activity|UDPG phosphorylase activity|UDPG pyrophosphorylase activity|UTP-glucose-1-phosphate uridylyltransferase activity|UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity|glucose-1-phosphate uridylyltransferase activity|uridine 5'-diphosphoglucose pyrophosphorylase activity|uridine diphosphate-D-glucose pyrophosphorylase activity|uridine diphosphoglucose pyrophosphorylase activity|uridine-diphosphate glucose pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0003983 GO:0003980 biolink:MolecularActivity UDP-glucose:glycoprotein glucosyltransferase activity Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. RHEA:61304|Reactome:R-HSA-548884 go.json UGGT activity http://purl.obolibrary.org/obo/GO_0003980 GO:1904547 biolink:BiologicalProcess regulation of cellular response to glucose starvation Any process that modulates the frequency, rate or extent of cellular response to glucose starvation. go.json http://purl.obolibrary.org/obo/GO_1904547 GO:1904546 biolink:BiologicalProcess obsolete negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway OBSOLETE. Any negative regulation of cAMP-dependent protein kinase activity that is involved in negative regulation of glucose mediated signaling pathway. go.json negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling|negative regulation of AMPK involved in down regulation of glucose mediated signaling pathway|negative regulation of AMPK involved in down regulation of glucose mediated signalling|negative regulation of AMPK involved in down-regulation of glucose mediated signaling pathway|negative regulation of AMPK involved in down-regulation of glucose mediated signalling|negative regulation of AMPK involved in downregulation of glucose mediated signaling pathway|negative regulation of AMPK involved in downregulation of glucose mediated signalling|negative regulation of AMPK involved in inhibition of glucose mediated signaling pathway|negative regulation of AMPK involved in inhibition of glucose mediated signalling|negative regulation of AMPK involved in negative regulation of glucose mediated signaling pathway|negative regulation of AMPK involved in negative regulation of glucose mediated signalling|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signaling pathway|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signalling|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signalling|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signaling pathway|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signalling|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signaling pathway|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signalling|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signalling|negative regulation of PKA C involved in down regulation of glucose mediated signaling pathway|negative regulation of PKA C involved in down regulation of glucose mediated signalling|negative regulation of PKA C involved in down-regulation of glucose mediated signaling pathway|negative regulation of PKA C involved in down-regulation of glucose mediated signalling|negative regulation of PKA C involved in downregulation of glucose mediated signaling pathway|negative regulation of PKA C involved in downregulation of glucose mediated signalling|negative regulation of PKA C involved in inhibition of glucose mediated signaling pathway|negative regulation of PKA C involved in inhibition of glucose mediated signalling|negative regulation of PKA C involved in negative regulation of glucose mediated signaling pathway|negative regulation of PKA C involved in negative regulation of glucose mediated signalling|negative regulation of PKA involved in down regulation of glucose mediated signaling pathway|negative regulation of PKA involved in down regulation of glucose mediated signalling|negative regulation of PKA involved in down-regulation of glucose mediated signaling pathway|negative regulation of PKA involved in down-regulation of glucose mediated signalling|negative regulation of PKA involved in downregulation of glucose mediated signaling pathway|negative regulation of PKA involved in downregulation of glucose mediated signalling|negative regulation of PKA involved in inhibition of glucose mediated signaling pathway|negative regulation of PKA involved in inhibition of glucose mediated signalling|negative regulation of PKA involved in negative regulation of glucose mediated signaling pathway|negative regulation of PKA involved in negative regulation of glucose mediated signalling|negative regulation of STK22 involved in down regulation of glucose mediated signaling pathway|negative regulation of STK22 involved in down regulation of glucose mediated signalling|negative regulation of STK22 involved in down-regulation of glucose mediated signaling pathway|negative regulation of STK22 involved in down-regulation of glucose mediated signalling|negative regulation of STK22 involved in downregulation of glucose mediated signaling pathway|negative regulation of STK22 involved in downregulation of glucose mediated signalling|negative regulation of STK22 involved in inhibition of glucose mediated signaling pathway|negative regulation of STK22 involved in inhibition of glucose mediated signalling|negative regulation of STK22 involved in negative regulation of glucose mediated signaling pathway|negative regulation of STK22 involved in negative regulation of glucose mediated signalling|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signalling|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signalling|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signalling|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signalling|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signalling|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signalling|negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway|negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling|negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling|negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway|negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling|negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway|negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling|negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling|negative regulation of protein kinase A activity involved in down regulation of glucose mediated signaling pathway|negative regulation of protein kinase A activity involved in down regulation of glucose mediated signalling|negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signaling pathway|negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signalling|negative regulation of protein kinase A activity involved in downregulation of glucose mediated signaling pathway|negative regulation of protein kinase A activity involved in downregulation of glucose mediated signalling|negative regulation of protein kinase A activity involved in inhibition of glucose mediated signaling pathway|negative regulation of protein kinase A activity involved in inhibition of glucose mediated signalling|negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signaling pathway|negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signalling True http://purl.obolibrary.org/obo/GO_1904546 GO:1904544 biolink:BiologicalProcess positive regulation of free ubiquitin chain polymerization Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization. go.json activation of free ubiquitin chain polymerization|up regulation of free ubiquitin chain polymerization|up-regulation of free ubiquitin chain polymerization|upregulation of free ubiquitin chain polymerization http://purl.obolibrary.org/obo/GO_1904544 GO:1904543 biolink:BiologicalProcess negative regulation of free ubiquitin chain polymerization Any process that stops, prevents or reduces the frequency, rate or extent of free ubiquitin chain polymerization. go.json down regulation of free ubiquitin chain polymerization|down-regulation of free ubiquitin chain polymerization|downregulation of free ubiquitin chain polymerization|inhibition of free ubiquitin chain polymerization http://purl.obolibrary.org/obo/GO_1904543 GO:1904542 biolink:BiologicalProcess regulation of free ubiquitin chain polymerization Any process that modulates the frequency, rate or extent of free ubiquitin chain polymerization. go.json http://purl.obolibrary.org/obo/GO_1904542 GO:1904552 biolink:BiologicalProcess regulation of chemotaxis to arachidonic acid Any process that modulates the frequency, rate or extent of chemotaxis to arachidonic acid. go.json http://purl.obolibrary.org/obo/GO_1904552 GO:1904551 biolink:BiologicalProcess cellular response to arachidonic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1904551 GO:1904550 biolink:BiologicalProcess response to arachidonic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1904550 GO:0003989 biolink:MolecularActivity acetyl-CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. EC:6.4.1.2|MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN|RHEA:11308|Reactome:R-HSA-200555|Reactome:R-HSA-75851|Reactome:R-HSA-8876889 go.json acetyl coenzyme A carboxylase activity|acetyl-CoA:carbon-dioxide ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0003989 GO:0052902 biolink:MolecularActivity spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine. EC:1.5.3.13|EC:1.5.3.17|KEGG_REACTION:R09077|MetaCyc:RXN-12089|RHEA:25808 go.json N(1)-acetylpolyamine oxidase activity|non-specific polyamine oxidase activity|polyamine oxidase activity http://purl.obolibrary.org/obo/GO_0052902 GO:0052901 biolink:MolecularActivity spermine:oxygen oxidoreductase (spermidine-forming) activity Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine. EC:1.5.3.13|EC:1.5.3.16|EC:1.5.3.17|KEGG_REACTION:R09076|MetaCyc:RXN-9015|RHEA:25804|Reactome:R-HSA-141341 go.json N(1)-acetylpolyamine oxidase activity|non-specific polyamine oxidase activity|polyamine oxidase activity|spermine oxidase activity http://purl.obolibrary.org/obo/GO_0052901 GO:0052900 biolink:MolecularActivity spermine oxidase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H2O + O2 + spermine = 1,3-diaminopropane + H2O2 + N-(3-aminopropyl)-4-aminobutanal. EC:1.5.3.14|MetaCyc:RXN-6421|RHEA:25824 go.json polyamine oxidase (propane-1,3-diamine-forming) activity http://purl.obolibrary.org/obo/GO_0052900 GO:0052906 biolink:MolecularActivity tRNA (guanine(37)-N1)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.228|MetaCyc:RXN-12458|RHEA:36899 go.json tRNA (guanine(37)-N(1))-methyltransferase activity|tRNA (guanosine(37)-N(1))-methyltransferase activity|tRNA (guanosine(37)-N1-)-methyltransferase activity|tRNA (m(1)G(37)) methyltransferase activity|tRNA-(N(1)G37) methyltransferase activity|transfer RNA (m(1)G(37)) methyltransferase activity http://purl.obolibrary.org/obo/GO_0052906 GO:0052905 biolink:MolecularActivity tRNA (guanosine(9)-N1)-methyltransferase activity Catalysis of the reaction: guanosine9 in tRNA + S-adenosyl-L-methionine = H+ + N1-methylguanosine9 in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.221|MetaCyc:RXN-12459|RHEA:43156 go.json tRNA (guanine(9)-N(1))-methyltransferase activity|tRNA (guanine-N(1)-)-methyltransferase activity|tRNA (guanosine(9)-N(1))-methyltransferase activity|tRNA (guanosine(9)-N1-)-methyltransferase activity|tRNA m(1)G(9) Mtase activity|tRNA m(1)G(9)-methyltransferase activity|tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity|tRNA(m(1)G(9)/m(1)A(9))Mtase activity http://purl.obolibrary.org/obo/GO_0052905 GO:0052904 biolink:MolecularActivity N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine. EC:1.5.3.13|EC:1.5.3.17|KEGG_REACTION:R09074|MetaCyc:RXN-12091|RHEA:25812|Reactome:R-HSA-141348|Reactome:R-HSA-141351 go.json N(1)-acetylpolyamine oxidase activity|non-specific polyamine oxidase activity|polyamine oxidase activity http://purl.obolibrary.org/obo/GO_0052904 GO:0052903 biolink:MolecularActivity N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine. EC:1.5.3.13|EC:1.5.3.17|KEGG_REACTION:R03899|MetaCyc:RXN-12090|MetaCyc:RXN-9940|RHEA:25800 go.json N(1)-acetylpolyamine oxidase activity|non-specific polyamine oxidase activity|polyamine oxidase activity http://purl.obolibrary.org/obo/GO_0052903 GO:0052909 biolink:MolecularActivity 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA. EC:2.1.1.183|MetaCyc:RXN-11634|RHEA:42780 go.json M(6)(2)A dimethylase activity http://purl.obolibrary.org/obo/GO_0052909 GO:0052908 biolink:MolecularActivity 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA. EC:2.1.1.182|MetaCyc:RXN-11633|RHEA:19609 go.json S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity http://purl.obolibrary.org/obo/GO_0052908 GO:0052907 biolink:MolecularActivity 23S rRNA (adenine(1618)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. EC:2.1.1.181|KEGG_REACTION:R07232|MetaCyc:RXN-11596|RHEA:16497 go.json M(6)A(1618) activity|rRNA large subunit methyltransferase F activity http://purl.obolibrary.org/obo/GO_0052907 GO:0052913 biolink:MolecularActivity 16S rRNA (guanine(966)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine. EC:2.1.1.171|KEGG_REACTION:R07234|MetaCyc:RXN0-6515|RHEA:23548 go.json http://purl.obolibrary.org/obo/GO_0052913 GO:0052912 biolink:MolecularActivity 23S rRNA (guanine(748)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine. EC:2.1.1.188|KEGG_REACTION:R07233|MetaCyc:RXN-11599|RHEA:42904 go.json 23S rRNA m(1)G(748) methyltransferase activity http://purl.obolibrary.org/obo/GO_0052912 GO:0052911 biolink:MolecularActivity 23S rRNA (guanine(745)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine. EC:2.1.1.187|KEGG_REACTION:R07233|MetaCyc:RXN-11573|RHEA:42900 go.json 23S rRNA m(1)G(745) methyltransferase activity|S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity|rRNA(m(1)G)methylase activity|ribosomal RNA(m(1)G)-methylase activity|ribosomal ribonucleate guanine 1-methyltransferase activity|rlmA(I) methyltransferase activity http://purl.obolibrary.org/obo/GO_0052911 GO:0052910 biolink:MolecularActivity 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA. EC:2.1.1.184|MetaCyc:RXN-11597|RHEA:42784 go.json ermC 23S rRNA methyltransferase activity|rRNA methyltransferase ermC' activity|rRNA:m(6)A methyltransferase ermC' activity http://purl.obolibrary.org/obo/GO_0052910 GO:0052917 biolink:MolecularActivity dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol. EC:2.4.1.260|KEGG_REACTION:R06260|MetaCyc:RXN-5468|RHEA:29535 go.json dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity|dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity|dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0052917 GO:0052916 biolink:MolecularActivity 23S rRNA (guanine(1835)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine. EC:2.1.1.174|KEGG_REACTION:R07234|MetaCyc:RXN-11635|RHEA:42744 go.json http://purl.obolibrary.org/obo/GO_0052916 GO:0052915 biolink:MolecularActivity 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine. EC:2.1.1.173|KEGG_REACTION:R07234|MetaCyc:RXN-11574|RHEA:42740 go.json http://purl.obolibrary.org/obo/GO_0052915 GO:0052914 biolink:MolecularActivity 16S rRNA (guanine(1207)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine. EC:2.1.1.172|KEGG_REACTION:R07234|MetaCyc:RXN-11576|RHEA:42736 go.json M(2)G1207 methyltransferase activity http://purl.obolibrary.org/obo/GO_0052914 GO:0052919 biolink:MolecularActivity aliphatic (R)-hydroxynitrile lyase activity Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide. EC:4.1.2.46 go.json (R)-HNL activity|(R)-hydroxynitrile lyase activity|(R)-oxynitrilase activity http://purl.obolibrary.org/obo/GO_0052919 GO:0052918 biolink:MolecularActivity dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. EC:2.4.1.261|KEGG_REACTION:R06261|MetaCyc:RXN-5469|RHEA:29539 go.json http://purl.obolibrary.org/obo/GO_0052918 GO:0052920 biolink:MolecularActivity obsolete (2R)-2-hydroxy-2-methylbutanenitrile lyase activity OBSOLETE. Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide. go.json True http://purl.obolibrary.org/obo/GO_0052920 GO:0052924 biolink:MolecularActivity all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate. EC:2.5.1.85|KEGG_REACTION:R09251|MetaCyc:RXN-11486|RHEA:27594 go.json nonaprenyl diphosphate synthase activity|solanesyl diphosphate synthase activity|solanesyl diphosphate synthetase activity http://purl.obolibrary.org/obo/GO_0052924 GO:0052923 biolink:MolecularActivity all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate. EC:2.5.1.84|KEGG_REACTION:R07267|KEGG_REACTION:R09250|MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN|RHEA:27563 go.json (E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity|SPP synthase activity|SPP-synthase activity|all-trans-nonaprenyl-diphosphate synthase activity|nonaprenyl diphosphate synthase activity|nonaprenyl pyrophosphate synthetase activity|polyprenylpyrophosphate synthetase activity|solPP synthase activity|solanesyl diphosphate synthetase activity|solanesyl pyrophosphate synthetase activity|solanesyl-diphosphate synthase activity|terpenoidallyltransferase activity|terpenyl pyrophosphate synthetase activity|trans-octaprenyltranstransferase activity|trans-prenyltransferase activity http://purl.obolibrary.org/obo/GO_0052923 GO:0052922 biolink:MolecularActivity hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate. EC:2.5.1.82|KEGG_REACTION:R09246|MetaCyc:RXN-11485|RHEA:27555 go.json (all-E) hexaprenyl diphosphate synthase activity|(all-trans)-hexaprenyl-diphosphate synthase activity|hexaprenyl diphosphate synthase activity|hexaprenyl pyrophosphate synthetase activity http://purl.obolibrary.org/obo/GO_0052922 GO:0052921 biolink:MolecularActivity obsolete acetone-cyanohydrin acetone-lyase (cyanide-forming) activity OBSOLETE. Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone. go.json True http://purl.obolibrary.org/obo/GO_0052921 GO:0052928 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052928 GO:0052927 biolink:MolecularActivity CTP:tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' CC end + 2 diphosphate. RHEA:60008 go.json CTP:3'-cytidine-tRNA cytidylyltransferase activity http://purl.obolibrary.org/obo/GO_0052927 GO:0052926 biolink:MolecularActivity dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. EC:2.4.1.259|KEGG_REACTION:R06259|MetaCyc:RXN-5467|RHEA:29531 go.json dolichylphosphomannose-dependent ALG9 mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0052926 GO:0052925 biolink:MolecularActivity dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. EC:2.4.1.258|KEGG_REACTION:R06258|MetaCyc:RXN-5466|RHEA:29527 go.json dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity|man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0052925 GO:0052929 biolink:MolecularActivity ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate. KEGG_REACTION:R09386|RHEA:60012 go.json ATP:3'-CC-tRNA adenylyltransferase activity|ATP:tRNA adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0052929 GO:0052931 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052931 GO:0052930 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052930 GO:0052935 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052935 GO:0052934 biolink:MolecularActivity alcohol dehydrogenase (cytochrome c) activity Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+. EC:1.1.2.8|KEGG_REACTION:R05198|KEGG_REACTION:R05285|MetaCyc:RXN-11333|RHEA:51020|UM-BBD_enzymeID:e0004 go.json 2-chloroethanol:cytochrome c oxidoreductase activity|PQQ-dependent alcohol dehydrogenase activity|alcohol dehydrogenase (acceptor) activity|alcohol:(acceptor) oxidoreductase activity|alcohol:acceptor oxidoreductase activity|alcohol:cytochrome c oxidoreductase activity|ethanol:cytochrome c oxidoreductase activity|quinoprotein alcohol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052934 GO:0052933 biolink:MolecularActivity alcohol dehydrogenase (cytochrome c(L)) activity Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+. EC:1.1.2.7|KEGG_REACTION:R01146|KEGG_REACTION:R09127|KEGG_REACTION:R09128|MetaCyc:RXN-11332|MetaCyc:RXN-2861|RHEA:51004 go.json 2-chloroethanol cytochrome-c oxidoreductase activity|alcohol:cytochrome c(L) oxidoreductase activity|ethanol cytochrome-c oxidoreductase activity|methanol dehydrogenase activity|methanol ferricytochrome-c oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052933 GO:0052932 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052932 GO:0052936 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052936 GO:1904839 biolink:BiologicalProcess negative regulation of male germ-line stem cell asymmetric division Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division. go.json down regulation of male germ-line stem cell asymmetric division|down regulation of male germ-line stem cell renewal|down-regulation of male germ-line stem cell asymmetric division|down-regulation of male germ-line stem cell renewal|downregulation of male germ-line stem cell asymmetric division|downregulation of male germ-line stem cell renewal|inhibition of male germ-line stem cell asymmetric division|inhibition of male germ-line stem cell renewal|negative regulation of male germ-line stem cell renewal http://purl.obolibrary.org/obo/GO_1904839 GO:1904838 biolink:BiologicalProcess regulation of male germ-line stem cell asymmetric division Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division. go.json regulation of male germ-line stem cell renewal http://purl.obolibrary.org/obo/GO_1904838 GO:1904837 biolink:BiologicalProcess beta-catenin-TCF complex assembly The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. go.json beta-catenin-TCF complex formation|beta-catenin/LEF complex assembly|beta-catenin/LEF complex formation|beta-catenin/T-cell factor complex assembly|beta-catenin/T-cell factor complex formation|beta-catenin/lymphoid enhancer binding factor complex assembly|beta-catenin/lymphoid enhancer binding factor complex formation http://purl.obolibrary.org/obo/GO_1904837 GO:1904836 biolink:BiologicalProcess facioacoustic ganglion morphogenesis The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized. go.json acoustico-facial VII-VIII ganglion complex morphogenesis|acousticofacial ganglion morphogenesis|facio-acoustic VII-VIII ganglion complex morphogenesis|facio-acoustic ganglion complex VII-VIII morphogenesis|facio-acoustic ganglion complex morphogenesis|facio-acoustic ganglion morphogenesis http://purl.obolibrary.org/obo/GO_1904836 GO:1904835 biolink:BiologicalProcess dorsal root ganglion morphogenesis The developmental process by which a dorsal root ganglion is generated and organized. go.json DRG morphogenesis|dorsal root ganglia morphogenesis|ganglion of dorsal root morphogenesis|ganglion sensorium nervi spinalis morphogenesis|ganglion spinale morphogenesis|ganglion spinalis morphogenesis|posterior root ganglion morphogenesis|spinal ganglion morphogenesis|spinal ganglion part of peripheral nervous system morphogenesis http://purl.obolibrary.org/obo/GO_1904835 GO:1904834 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904834 GO:1904833 biolink:BiologicalProcess positive regulation of removal of superoxide radicals Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals. go.json activation of cellular detoxification of superoxide radicals|activation of removal of O2-|activation of removal of oxygen free radicals|activation of removal of superoxide radicals|positive regulation of cellular detoxification of superoxide radicals|positive regulation of removal of O2-|positive regulation of removal of oxygen free radicals|up regulation of cellular detoxification of superoxide radicals|up regulation of removal of O2-|up regulation of removal of oxygen free radicals|up regulation of removal of superoxide radicals|up-regulation of cellular detoxification of superoxide radicals|up-regulation of removal of O2-|up-regulation of removal of oxygen free radicals|up-regulation of removal of superoxide radicals|upregulation of cellular detoxification of superoxide radicals|upregulation of removal of O2-|upregulation of removal of oxygen free radicals|upregulation of removal of superoxide radicals http://purl.obolibrary.org/obo/GO_1904833 GO:1904832 biolink:BiologicalProcess negative regulation of removal of superoxide radicals Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals. go.json down regulation of cellular detoxification of superoxide radicals|down regulation of removal of O2-|down regulation of removal of oxygen free radicals|down regulation of removal of superoxide radicals|down-regulation of cellular detoxification of superoxide radicals|down-regulation of removal of O2-|down-regulation of removal of oxygen free radicals|down-regulation of removal of superoxide radicals|downregulation of cellular detoxification of superoxide radicals|downregulation of removal of O2-|downregulation of removal of oxygen free radicals|downregulation of removal of superoxide radicals|inhibition of cellular detoxification of superoxide radicals|inhibition of removal of O2-|inhibition of removal of oxygen free radicals|inhibition of removal of superoxide radicals|negative regulation of cellular detoxification of superoxide radicals|negative regulation of removal of O2-|negative regulation of removal of oxygen free radicals http://purl.obolibrary.org/obo/GO_1904832 GO:1904831 biolink:BiologicalProcess positive regulation of aortic smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. go.json activation of aortic smooth muscle cell differentiation|up regulation of aortic smooth muscle cell differentiation|up-regulation of aortic smooth muscle cell differentiation|upregulation of aortic smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_1904831 GO:1904830 biolink:BiologicalProcess negative regulation of aortic smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. go.json down regulation of aortic smooth muscle cell differentiation|down-regulation of aortic smooth muscle cell differentiation|downregulation of aortic smooth muscle cell differentiation|inhibition of aortic smooth muscle cell differentiation http://purl.obolibrary.org/obo/GO_1904830 GO:1904849 biolink:BiologicalProcess positive regulation of cell chemotaxis to fibroblast growth factor Any process that activates or increases the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. go.json activation of cell chemotaxis to fibroblast growth factor|up regulation of cell chemotaxis to fibroblast growth factor|up-regulation of cell chemotaxis to fibroblast growth factor|upregulation of cell chemotaxis to fibroblast growth factor http://purl.obolibrary.org/obo/GO_1904849 GO:1904848 biolink:BiologicalProcess negative regulation of cell chemotaxis to fibroblast growth factor Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. go.json down regulation of cell chemotaxis to fibroblast growth factor|down-regulation of cell chemotaxis to fibroblast growth factor|downregulation of cell chemotaxis to fibroblast growth factor|inhibition of cell chemotaxis to fibroblast growth factor http://purl.obolibrary.org/obo/GO_1904848 GO:1904847 biolink:BiologicalProcess regulation of cell chemotaxis to fibroblast growth factor Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. go.json http://purl.obolibrary.org/obo/GO_1904847 GO:1904846 biolink:BiologicalProcess negative regulation of establishment of bipolar cell polarity Any process that stops, prevents or reduces the frequency, rate or extent of establishment of bipolar cell polarity. go.json down regulation of establishment of bipolar cell polarity|down-regulation of establishment of bipolar cell polarity|downregulation of establishment of bipolar cell polarity|inhibition of establishment of bipolar cell polarity http://purl.obolibrary.org/obo/GO_1904846 GO:1904845 biolink:BiologicalProcess cellular response to L-glutamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904845 GO:1904844 biolink:BiologicalProcess response to L-glutamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904844 GO:1904843 biolink:BiologicalProcess cellular response to nitroglycerin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. go.json cellular response to nitroglycerine|cellular response to nitroglycerol|cellular response to trinitroglycerin|cellular response to trinitroglycerol http://purl.obolibrary.org/obo/GO_1904843 GO:1904842 biolink:BiologicalProcess response to nitroglycerin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. go.json response to nitroglycerine|response to nitroglycerol|response to trinitroglycerin|response to trinitroglycerol http://purl.obolibrary.org/obo/GO_1904842 GO:1904841 biolink:MolecularActivity TORC2 complex binding Binding to a TORC2 complex. go.json TOR complex 2 binding|TORC 2 complex binding|TORC2 binding|mTORC2 binding|rapamycin and nutrient-insensitive TOR complex binding http://purl.obolibrary.org/obo/GO_1904841 GO:1904840 biolink:BiologicalProcess positive regulation of male germ-line stem cell asymmetric division Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division. go.json activation of male germ-line stem cell asymmetric division|activation of male germ-line stem cell renewal|positive regulation of male germ-line stem cell renewal|up regulation of male germ-line stem cell asymmetric division|up regulation of male germ-line stem cell renewal|up-regulation of male germ-line stem cell asymmetric division|up-regulation of male germ-line stem cell renewal|upregulation of male germ-line stem cell asymmetric division|upregulation of male germ-line stem cell renewal http://purl.obolibrary.org/obo/GO_1904840 GO:1904859 biolink:BiologicalProcess positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. go.json activation of endothelial cell chemotaxis to vascular endothelial growth factor|up regulation of endothelial cell chemotaxis to vascular endothelial growth factor|up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor|upregulation of endothelial cell chemotaxis to vascular endothelial growth factor http://purl.obolibrary.org/obo/GO_1904859 GO:1904858 biolink:BiologicalProcess negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. go.json down regulation of endothelial cell chemotaxis to vascular endothelial growth factor|down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor|downregulation of endothelial cell chemotaxis to vascular endothelial growth factor|inhibition of endothelial cell chemotaxis to vascular endothelial growth factor http://purl.obolibrary.org/obo/GO_1904858 GO:1904857 biolink:BiologicalProcess regulation of endothelial cell chemotaxis to vascular endothelial growth factor Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. go.json http://purl.obolibrary.org/obo/GO_1904857 GO:1904856 biolink:CellularComponent cytolytic granule lumen Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule. go.json cytolytic granule cytoplasmic membrane-bounded vesicle lumen|cytoplasmic membrane-bounded vesicle lumen of cytolytic granule|cytoplasmic membrane-enclosed vesicle lumen of cytolytic granule http://purl.obolibrary.org/obo/GO_1904856 GO:1904855 biolink:MolecularActivity proteasome regulatory particle binding Binding to a proteasome regulatory particle. go.json 19S regulatory particle binding|PA700 proteasome activator binding|PA700-dependent proteasome activator binding|modulator complex binding http://purl.obolibrary.org/obo/GO_1904855 GO:1904854 biolink:MolecularActivity proteasome core complex binding Binding to a proteasome core complex. go.json 20S core complex binding|20S proteasome binding|PA28gamma-20S proteasome binding|macropain binding http://purl.obolibrary.org/obo/GO_1904854 GO:1904853 biolink:BiologicalProcess protein localization to ascospore wall A process in which a protein is transported to, or maintained in, a location within an ascospore wall. go.json protein localisation in ascospore wall|protein localisation to ascospore wall|protein localization in ascospore wall http://purl.obolibrary.org/obo/GO_1904853 GO:1904852 biolink:CellularComponent trimethylamine-N-oxide reductase (cytochrome c) complex A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity. go.json http://purl.obolibrary.org/obo/GO_1904852 GO:1904851 biolink:BiologicalProcess positive regulation of establishment of protein localization to telomere Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere. go.json activation of establishment of protein localisation to telomere|activation of establishment of protein localization to chromosome, telomeric region|activation of establishment of protein localization to telomere|positive regulation of establishment of protein localisation to telomere|positive regulation of establishment of protein localization to chromosome, telomeric region|up regulation of establishment of protein localisation to telomere|up regulation of establishment of protein localization to chromosome, telomeric region|up regulation of establishment of protein localization to telomere|up-regulation of establishment of protein localisation to telomere|up-regulation of establishment of protein localization to chromosome, telomeric region|up-regulation of establishment of protein localization to telomere|upregulation of establishment of protein localisation to telomere|upregulation of establishment of protein localization to chromosome, telomeric region|upregulation of establishment of protein localization to telomere http://purl.obolibrary.org/obo/GO_1904851 GO:1904850 biolink:BiologicalProcess negative regulation of establishment of protein localization to telomere Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere. go.json down regulation of establishment of protein localisation to telomere|down regulation of establishment of protein localization to chromosome, telomeric region|down regulation of establishment of protein localization to telomere|down-regulation of establishment of protein localisation to telomere|down-regulation of establishment of protein localization to chromosome, telomeric region|down-regulation of establishment of protein localization to telomere|downregulation of establishment of protein localisation to telomere|downregulation of establishment of protein localization to chromosome, telomeric region|downregulation of establishment of protein localization to telomere|inhibition of establishment of protein localisation to telomere|inhibition of establishment of protein localization to chromosome, telomeric region|inhibition of establishment of protein localization to telomere|negative regulation of establishment of protein localisation to telomere|negative regulation of establishment of protein localization to chromosome, telomeric region http://purl.obolibrary.org/obo/GO_1904850 GO:1904860 biolink:BiologicalProcess DNA synthesis involved in mitotic DNA replication Any DNA biosynthetic process that is involved in mitotic DNA replication. go.json DNA anabolism involved in DNA replication during S phase involved in mitotic cell cycle|DNA anabolism involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA anabolism involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA anabolism involved in mitotic DNA replication|DNA anabolism involved in mitotic cell cycle DNA replication|DNA anabolism involved in mitotic nuclear cell cycle DNA replication|DNA anabolism involved in nuclear cell cycle DNA replication involved in mitotic cell cycle|DNA biosynthesis involved in DNA replication during S phase involved in mitotic cell cycle|DNA biosynthesis involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA biosynthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA biosynthesis involved in mitotic DNA replication|DNA biosynthesis involved in mitotic cell cycle DNA replication|DNA biosynthesis involved in mitotic nuclear cell cycle DNA replication|DNA biosynthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle|DNA biosynthetic process involved in DNA replication during S phase involved in mitotic cell cycle|DNA biosynthetic process involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA biosynthetic process involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA biosynthetic process involved in mitotic DNA replication|DNA biosynthetic process involved in mitotic cell cycle DNA replication|DNA biosynthetic process involved in mitotic nuclear cell cycle DNA replication|DNA biosynthetic process involved in nuclear cell cycle DNA replication involved in mitotic cell cycle|DNA formation involved in DNA replication during S phase involved in mitotic cell cycle|DNA formation involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA formation involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA formation involved in mitotic DNA replication|DNA formation involved in mitotic cell cycle DNA replication|DNA formation involved in mitotic nuclear cell cycle DNA replication|DNA formation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle|DNA synthesis involved in DNA replication during S phase involved in mitotic cell cycle|DNA synthesis involved in DNA replication involved in S phase involved in mitotic cell cycle|DNA synthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle|DNA synthesis involved in mitotic cell cycle DNA replication|DNA synthesis involved in mitotic nuclear cell cycle DNA replication|DNA synthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_1904860 GO:1904869 biolink:BiologicalProcess regulation of protein localization to Cajal body Any process that modulates the frequency, rate or extent of protein localization to Cajal body. go.json regulation of protein localisation in Cajal body|regulation of protein localisation to Cajal body|regulation of protein localization in Cajal body http://purl.obolibrary.org/obo/GO_1904869 GO:1904868 biolink:BiologicalProcess telomerase catalytic core complex assembly The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex. go.json TERT-TERC complex assembly|TERT-TERC complex formation|telomerase catalytic core complex formation http://purl.obolibrary.org/obo/GO_1904868 GO:1904867 biolink:BiologicalProcess protein localization to Cajal body A process in which a protein is transported to, or maintained in, a location within a Cajal body. go.json protein localisation in Cajal body|protein localisation to Cajal body|protein localization in Cajal body http://purl.obolibrary.org/obo/GO_1904867 GO:1904866 biolink:BiologicalProcess ventral tegmental area development The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure. go.json VTA development|a10a development|area tegmentalis ventralis (Tsai) development|area tegmentalis ventralis development|tegmentum ventrale development|ventral brain stem development|ventral tegmental area (Tsai) development|ventral tegmental area of tsai development|ventral tegmental nucleus (Rioch) development|ventral tegmental nucleus (tsai) development|ventral tegmental nucleus of tsai development|ventral tegmentum development|ventromedial mesencephalic tegmentum development http://purl.obolibrary.org/obo/GO_1904866 GO:1904865 biolink:BiologicalProcess positive regulation of beta-catenin-TCF complex assembly Any process that activates or increases the frequency, rate or extent of beta-catenin-TCF complex assembly. go.json activation of beta-catenin-TCF complex assembly|activation of beta-catenin-TCF complex formation|activation of beta-catenin/LEF complex assembly|activation of beta-catenin/LEF complex formation|activation of beta-catenin/T-cell factor complex assembly|activation of beta-catenin/T-cell factor complex formation|activation of beta-catenin/lymphoid enhancer binding factor complex assembly|activation of beta-catenin/lymphoid enhancer binding factor complex formation|positive regulation of beta-catenin-TCF complex formation|positive regulation of beta-catenin/LEF complex assembly|positive regulation of beta-catenin/LEF complex formation|positive regulation of beta-catenin/T-cell factor complex assembly|positive regulation of beta-catenin/T-cell factor complex formation|positive regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|positive regulation of beta-catenin/lymphoid enhancer binding factor complex formation|up regulation of beta-catenin-TCF complex assembly|up regulation of beta-catenin-TCF complex formation|up regulation of beta-catenin/LEF complex assembly|up regulation of beta-catenin/LEF complex formation|up regulation of beta-catenin/T-cell factor complex assembly|up regulation of beta-catenin/T-cell factor complex formation|up regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|up regulation of beta-catenin/lymphoid enhancer binding factor complex formation|up-regulation of beta-catenin-TCF complex assembly|up-regulation of beta-catenin-TCF complex formation|up-regulation of beta-catenin/LEF complex assembly|up-regulation of beta-catenin/LEF complex formation|up-regulation of beta-catenin/T-cell factor complex assembly|up-regulation of beta-catenin/T-cell factor complex formation|up-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|up-regulation of beta-catenin/lymphoid enhancer binding factor complex formation|upregulation of beta-catenin-TCF complex assembly|upregulation of beta-catenin-TCF complex formation|upregulation of beta-catenin/LEF complex assembly|upregulation of beta-catenin/LEF complex formation|upregulation of beta-catenin/T-cell factor complex assembly|upregulation of beta-catenin/T-cell factor complex formation|upregulation of beta-catenin/lymphoid enhancer binding factor complex assembly|upregulation of beta-catenin/lymphoid enhancer binding factor complex formation http://purl.obolibrary.org/obo/GO_1904865 GO:1904864 biolink:BiologicalProcess negative regulation of beta-catenin-TCF complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly. go.json down regulation of beta-catenin-TCF complex assembly|down regulation of beta-catenin-TCF complex formation|down regulation of beta-catenin/LEF complex assembly|down regulation of beta-catenin/LEF complex formation|down regulation of beta-catenin/T-cell factor complex assembly|down regulation of beta-catenin/T-cell factor complex formation|down regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|down regulation of beta-catenin/lymphoid enhancer binding factor complex formation|down-regulation of beta-catenin-TCF complex assembly|down-regulation of beta-catenin-TCF complex formation|down-regulation of beta-catenin/LEF complex assembly|down-regulation of beta-catenin/LEF complex formation|down-regulation of beta-catenin/T-cell factor complex assembly|down-regulation of beta-catenin/T-cell factor complex formation|down-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|down-regulation of beta-catenin/lymphoid enhancer binding factor complex formation|downregulation of beta-catenin-TCF complex assembly|downregulation of beta-catenin-TCF complex formation|downregulation of beta-catenin/LEF complex assembly|downregulation of beta-catenin/LEF complex formation|downregulation of beta-catenin/T-cell factor complex assembly|downregulation of beta-catenin/T-cell factor complex formation|downregulation of beta-catenin/lymphoid enhancer binding factor complex assembly|downregulation of beta-catenin/lymphoid enhancer binding factor complex formation|inhibition of beta-catenin-TCF complex assembly|inhibition of beta-catenin-TCF complex formation|inhibition of beta-catenin/LEF complex assembly|inhibition of beta-catenin/LEF complex formation|inhibition of beta-catenin/T-cell factor complex assembly|inhibition of beta-catenin/T-cell factor complex formation|inhibition of beta-catenin/lymphoid enhancer binding factor complex assembly|inhibition of beta-catenin/lymphoid enhancer binding factor complex formation|negative regulation of beta-catenin-TCF complex formation|negative regulation of beta-catenin/LEF complex assembly|negative regulation of beta-catenin/LEF complex formation|negative regulation of beta-catenin/T-cell factor complex assembly|negative regulation of beta-catenin/T-cell factor complex formation|negative regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|negative regulation of beta-catenin/lymphoid enhancer binding factor complex formation http://purl.obolibrary.org/obo/GO_1904864 GO:1904863 biolink:BiologicalProcess regulation of beta-catenin-TCF complex assembly Any process that modulates the frequency, rate or extent of beta-catenin-TCF complex assembly. go.json regulation of beta-catenin-TCF complex formation|regulation of beta-catenin/LEF complex assembly|regulation of beta-catenin/LEF complex formation|regulation of beta-catenin/T-cell factor complex assembly|regulation of beta-catenin/T-cell factor complex formation|regulation of beta-catenin/lymphoid enhancer binding factor complex assembly|regulation of beta-catenin/lymphoid enhancer binding factor complex formation http://purl.obolibrary.org/obo/GO_1904863 GO:1904862 biolink:BiologicalProcess inhibitory synapse assembly The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse. go.json inhibitory synapse formation http://purl.obolibrary.org/obo/GO_1904862 GO:1904861 biolink:BiologicalProcess excitatory synapse assembly The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse. go.json excitatory synapse formation http://purl.obolibrary.org/obo/GO_1904861 GO:1904871 biolink:BiologicalProcess positive regulation of protein localization to Cajal body Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body. go.json activation of protein localisation in Cajal body|activation of protein localisation to Cajal body|activation of protein localization in Cajal body|activation of protein localization to Cajal body|positive regulation of protein localisation in Cajal body|positive regulation of protein localisation to Cajal body|positive regulation of protein localization in Cajal body|up regulation of protein localisation in Cajal body|up regulation of protein localisation to Cajal body|up regulation of protein localization in Cajal body|up regulation of protein localization to Cajal body|up-regulation of protein localisation in Cajal body|up-regulation of protein localisation to Cajal body|up-regulation of protein localization in Cajal body|up-regulation of protein localization to Cajal body|upregulation of protein localisation in Cajal body|upregulation of protein localisation to Cajal body|upregulation of protein localization in Cajal body|upregulation of protein localization to Cajal body http://purl.obolibrary.org/obo/GO_1904871 GO:1904870 biolink:BiologicalProcess negative regulation of protein localization to Cajal body Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body. go.json down regulation of protein localisation in Cajal body|down regulation of protein localisation to Cajal body|down regulation of protein localization in Cajal body|down regulation of protein localization to Cajal body|down-regulation of protein localisation in Cajal body|down-regulation of protein localisation to Cajal body|down-regulation of protein localization in Cajal body|down-regulation of protein localization to Cajal body|downregulation of protein localisation in Cajal body|downregulation of protein localisation to Cajal body|downregulation of protein localization in Cajal body|downregulation of protein localization to Cajal body|inhibition of protein localisation in Cajal body|inhibition of protein localisation to Cajal body|inhibition of protein localization in Cajal body|inhibition of protein localization to Cajal body|negative regulation of protein localisation in Cajal body|negative regulation of protein localisation to Cajal body|negative regulation of protein localization in Cajal body http://purl.obolibrary.org/obo/GO_1904870 GO:1904879 biolink:BiologicalProcess positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel. go.json activation of generation of L-type calcium current|positive regulation of generation of L-type calcium current|up regulation of generation of L-type calcium current|up-regulation of generation of L-type calcium current|upregulation of generation of L-type calcium current http://purl.obolibrary.org/obo/GO_1904879 GO:1904878 biolink:BiologicalProcess negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel. go.json down regulation of generation of L-type calcium current|down-regulation of generation of L-type calcium current|downregulation of generation of L-type calcium current|inhibition of generation of L-type calcium current|negative regulation of generation of L-type calcium current http://purl.obolibrary.org/obo/GO_1904878 GO:1904877 biolink:BiologicalProcess positive regulation of DNA ligase activity Any process that activates or increases the frequency, rate or extent of DNA ligase activity. go.json activation of DNA ligase activity|up regulation of DNA ligase activity|up-regulation of DNA ligase activity|upregulation of DNA ligase activity http://purl.obolibrary.org/obo/GO_1904877 gocheck_do_not_annotate GO:1904876 biolink:BiologicalProcess negative regulation of DNA ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity. go.json down regulation of DNA ligase activity|down-regulation of DNA ligase activity|downregulation of DNA ligase activity|inhibition of DNA ligase activity http://purl.obolibrary.org/obo/GO_1904876 gocheck_do_not_annotate GO:1904875 biolink:BiologicalProcess regulation of DNA ligase activity Any process that modulates the frequency, rate or extent of DNA ligase activity. go.json http://purl.obolibrary.org/obo/GO_1904875 gocheck_do_not_annotate GO:1904874 biolink:BiologicalProcess positive regulation of telomerase RNA localization to Cajal body Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. go.json activation of telomerase RNA localization to Cajal body|up regulation of telomerase RNA localization to Cajal body|up-regulation of telomerase RNA localization to Cajal body|upregulation of telomerase RNA localization to Cajal body http://purl.obolibrary.org/obo/GO_1904874 GO:1904873 biolink:BiologicalProcess negative regulation of telomerase RNA localization to Cajal body Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA localization to Cajal body. go.json down regulation of telomerase RNA localization to Cajal body|down-regulation of telomerase RNA localization to Cajal body|downregulation of telomerase RNA localization to Cajal body|inhibition of telomerase RNA localization to Cajal body http://purl.obolibrary.org/obo/GO_1904873 GO:1904872 biolink:BiologicalProcess regulation of telomerase RNA localization to Cajal body Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. go.json http://purl.obolibrary.org/obo/GO_1904872 GO:1904882 biolink:BiologicalProcess regulation of telomerase catalytic core complex assembly Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly. go.json regulation of TERT-TERC complex assembly|regulation of TERT-TERC complex formation|regulation of telomerase catalytic core complex formation http://purl.obolibrary.org/obo/GO_1904882 GO:1904881 biolink:BiologicalProcess cellular response to hydrogen sulfide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus. go.json cellular response to dihydridosulfur|cellular response to sulfane http://purl.obolibrary.org/obo/GO_1904881 GO:1904880 biolink:BiologicalProcess response to hydrogen sulfide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus. go.json response to dihydridosulfur|response to sulfane http://purl.obolibrary.org/obo/GO_1904880 GO:1904889 biolink:BiologicalProcess regulation of excitatory synapse assembly Any process that modulates the frequency, rate or extent of excitatory synapse assembly. go.json regulation of excitatory synapse formation http://purl.obolibrary.org/obo/GO_1904889 GO:1904888 biolink:BiologicalProcess cranial skeletal system development The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. go.json cranial skeleton development|craniofacial development|cranium development|osteocranium development http://purl.obolibrary.org/obo/GO_1904888 GO:1904887 biolink:BiologicalProcess Wnt signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a Wnt signalosome. go.json LRP5/6 signalosome assembly|LRP5/6 signalosome formation|LRP6 signalosome assembly|LRP6 signalosome formation|Wnt signalosome complex assembly|Wnt signalosome complex formation|Wnt signalosome formation|Wnt-LRP5/6 signalosome assembly|Wnt-LRP5/6 signalosome formation http://purl.obolibrary.org/obo/GO_1904887 GO:1904886 biolink:BiologicalProcess beta-catenin destruction complex disassembly The disaggregation of a beta-catenin destruction complex into its constituent components. go.json 23S APC complex disassembly|APC-Axin-1-beta-catenin complex disassembly|Axin-APC-beta-catenin-GSK3B complex disassembly|BDC disassembly|beta-catenin degradation complex disassembly|dissociation of beta-catenin degradation complex http://purl.obolibrary.org/obo/GO_1904886 GO:1904885 biolink:BiologicalProcess beta-catenin destruction complex assembly The aggregation, arrangement and bonding together of a set of components to form a beta-catenin destruction complex. go.json 23S APC complex assembly|23S APC complex formation|APC-Axin-1-beta-catenin complex assembly|APC-Axin-1-beta-catenin complex formation|Axin-APC-beta-catenin-GSK3B complex assembly|Axin-APC-beta-catenin-GSK3B complex formation|BDC assembly|BDC formation|beta-catenin degradation complex assembly|beta-catenin degradation complex formation|beta-catenin destruction complex formation|destruction complex formation http://purl.obolibrary.org/obo/GO_1904885 GO:1904884 biolink:BiologicalProcess positive regulation of telomerase catalytic core complex assembly Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly. go.json activation of TERT-TERC complex assembly|activation of TERT-TERC complex formation|activation of telomerase catalytic core complex assembly|activation of telomerase catalytic core complex formation|positive regulation of TERT-TERC complex assembly|positive regulation of TERT-TERC complex formation|positive regulation of telomerase catalytic core complex formation|up regulation of TERT-TERC complex assembly|up regulation of TERT-TERC complex formation|up regulation of telomerase catalytic core complex assembly|up regulation of telomerase catalytic core complex formation|up-regulation of TERT-TERC complex assembly|up-regulation of TERT-TERC complex formation|up-regulation of telomerase catalytic core complex assembly|up-regulation of telomerase catalytic core complex formation|upregulation of TERT-TERC complex assembly|upregulation of TERT-TERC complex formation|upregulation of telomerase catalytic core complex assembly|upregulation of telomerase catalytic core complex formation http://purl.obolibrary.org/obo/GO_1904884 GO:1904883 biolink:BiologicalProcess negative regulation of telomerase catalytic core complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of telomerase catalytic core complex assembly. go.json down regulation of TERT-TERC complex assembly|down regulation of TERT-TERC complex formation|down regulation of telomerase catalytic core complex assembly|down regulation of telomerase catalytic core complex formation|down-regulation of TERT-TERC complex assembly|down-regulation of TERT-TERC complex formation|down-regulation of telomerase catalytic core complex assembly|down-regulation of telomerase catalytic core complex formation|downregulation of TERT-TERC complex assembly|downregulation of TERT-TERC complex formation|downregulation of telomerase catalytic core complex assembly|downregulation of telomerase catalytic core complex formation|inhibition of TERT-TERC complex assembly|inhibition of TERT-TERC complex formation|inhibition of telomerase catalytic core complex assembly|inhibition of telomerase catalytic core complex formation|negative regulation of TERT-TERC complex assembly|negative regulation of TERT-TERC complex formation|negative regulation of telomerase catalytic core complex formation http://purl.obolibrary.org/obo/GO_1904883 GO:1904893 biolink:BiologicalProcess negative regulation of receptor signaling pathway via STAT Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT. go.json down regulation of STAT cascade|down regulation of STAT signalling pathway|down regulation of kinase activated-STAT cascade|down regulation of kinase-STAT cascade|down-regulation of STAT cascade|down-regulation of STAT signalling pathway|down-regulation of kinase activated-STAT cascade|down-regulation of kinase-STAT cascade|downregulation of STAT cascade|downregulation of STAT signalling pathway|downregulation of kinase activated-STAT cascade|downregulation of kinase-STAT cascade|inhibition of STAT cascade|inhibition of STAT signalling pathway|inhibition of kinase activated-STAT cascade|inhibition of kinase-STAT cascade|negative regulation of STAT signalling pathway|negative regulation of kinase activated-STAT cascade|negative regulation of kinase-STAT cascade http://purl.obolibrary.org/obo/GO_1904893 GO:1904892 biolink:BiologicalProcess regulation of receptor signaling pathway via STAT Any process that modulates the frequency, rate or extent of receptor signaling via STAT. go.json regulation of STAT signalling pathway|regulation of kinase activated-STAT cascade|regulation of kinase-STAT cascade http://purl.obolibrary.org/obo/GO_1904892 GO:1904891 biolink:BiologicalProcess positive regulation of excitatory synapse assembly Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly. go.json activation of excitatory synapse assembly|activation of excitatory synapse formation|positive regulation of excitatory synapse formation|up regulation of excitatory synapse assembly|up regulation of excitatory synapse formation|up-regulation of excitatory synapse assembly|up-regulation of excitatory synapse formation|upregulation of excitatory synapse assembly|upregulation of excitatory synapse formation http://purl.obolibrary.org/obo/GO_1904891 GO:1904890 biolink:BiologicalProcess negative regulation of excitatory synapse assembly Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly. go.json down regulation of excitatory synapse assembly|down regulation of excitatory synapse formation|down-regulation of excitatory synapse assembly|down-regulation of excitatory synapse formation|downregulation of excitatory synapse assembly|downregulation of excitatory synapse formation|inhibition of excitatory synapse assembly|inhibition of excitatory synapse formation|negative regulation of excitatory synapse formation http://purl.obolibrary.org/obo/GO_1904890 GO:1904899 biolink:BiologicalProcess positive regulation of hepatic stellate cell proliferation Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation. go.json activation of Ito cell proliferation|activation of hepatic perisinusoidal cell proliferation|activation of hepatic stellate cell proliferation|activation of perisinusoidal cell proliferation|positive regulation of Ito cell proliferation|positive regulation of hepatic perisinusoidal cell proliferation|positive regulation of perisinusoidal cell proliferation|up regulation of Ito cell proliferation|up regulation of hepatic perisinusoidal cell proliferation|up regulation of hepatic stellate cell proliferation|up regulation of perisinusoidal cell proliferation|up-regulation of Ito cell proliferation|up-regulation of hepatic perisinusoidal cell proliferation|up-regulation of hepatic stellate cell proliferation|up-regulation of perisinusoidal cell proliferation|upregulation of Ito cell proliferation|upregulation of hepatic perisinusoidal cell proliferation|upregulation of hepatic stellate cell proliferation|upregulation of perisinusoidal cell proliferation http://purl.obolibrary.org/obo/GO_1904899 GO:1904898 biolink:BiologicalProcess negative regulation of hepatic stellate cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation. go.json down regulation of Ito cell proliferation|down regulation of hepatic perisinusoidal cell proliferation|down regulation of hepatic stellate cell proliferation|down regulation of perisinusoidal cell proliferation|down-regulation of Ito cell proliferation|down-regulation of hepatic perisinusoidal cell proliferation|down-regulation of hepatic stellate cell proliferation|down-regulation of perisinusoidal cell proliferation|downregulation of Ito cell proliferation|downregulation of hepatic perisinusoidal cell proliferation|downregulation of hepatic stellate cell proliferation|downregulation of perisinusoidal cell proliferation|inhibition of Ito cell proliferation|inhibition of hepatic perisinusoidal cell proliferation|inhibition of hepatic stellate cell proliferation|inhibition of perisinusoidal cell proliferation|negative regulation of Ito cell proliferation|negative regulation of hepatic perisinusoidal cell proliferation|negative regulation of perisinusoidal cell proliferation http://purl.obolibrary.org/obo/GO_1904898 GO:1904897 biolink:BiologicalProcess regulation of hepatic stellate cell proliferation Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation. go.json regulation of Ito cell proliferation|regulation of hepatic perisinusoidal cell proliferation|regulation of perisinusoidal cell proliferation http://purl.obolibrary.org/obo/GO_1904897 GO:1904896 biolink:BiologicalProcess ESCRT complex disassembly The disaggregation of an ESCRT complex into its constituent components. go.json endosomal sorting complex required for transport disassembly http://purl.obolibrary.org/obo/GO_1904896 GO:1904895 biolink:BiologicalProcess ESCRT complex assembly The aggregation, arrangement and bonding together of a set of components to form an ESCRT complex. go.json ESCRT complex formation|endosomal sorting complex required for transport assembly|endosomal sorting complex required for transport formation http://purl.obolibrary.org/obo/GO_1904895 GO:1904894 biolink:BiologicalProcess positive regulation of receptor signaling pathway via STAT Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT. go.json activation of STAT cascade|activation of STAT signalling pathway|activation of kinase activated-STAT cascade|activation of kinase-STAT cascade|positive regulation of STAT signalling pathway|positive regulation of kinase activated-STAT cascade|positive regulation of kinase-STAT cascade|up regulation of STAT cascade|up regulation of STAT signalling pathway|up regulation of kinase activated-STAT cascade|up regulation of kinase-STAT cascade|up-regulation of STAT cascade|up-regulation of STAT signalling pathway|up-regulation of kinase activated-STAT cascade|up-regulation of kinase-STAT cascade|upregulation of STAT cascade|upregulation of STAT signalling pathway|upregulation of kinase activated-STAT cascade|upregulation of kinase-STAT cascade http://purl.obolibrary.org/obo/GO_1904894 GO:1904809 biolink:BiologicalProcess regulation of dense core granule transport Any process that modulates the frequency, rate or extent of dense core granule transport. go.json regulation of dense core vesicle transport http://purl.obolibrary.org/obo/GO_1904809 GO:1904808 biolink:BiologicalProcess positive regulation of protein oxidation Any process that activates or increases the frequency, rate or extent of protein oxidation. go.json activation of protein amino acid oxidation|activation of protein oxidation|positive regulation of protein amino acid oxidation|up regulation of protein amino acid oxidation|up regulation of protein oxidation|up-regulation of protein amino acid oxidation|up-regulation of protein oxidation|upregulation of protein amino acid oxidation|upregulation of protein oxidation http://purl.obolibrary.org/obo/GO_1904808 GO:1904807 biolink:BiologicalProcess negative regulation of protein oxidation Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation. go.json down regulation of protein amino acid oxidation|down regulation of protein oxidation|down-regulation of protein amino acid oxidation|down-regulation of protein oxidation|downregulation of protein amino acid oxidation|downregulation of protein oxidation|inhibition of protein amino acid oxidation|inhibition of protein oxidation|negative regulation of protein amino acid oxidation http://purl.obolibrary.org/obo/GO_1904807 GO:1904806 biolink:BiologicalProcess regulation of protein oxidation Any process that modulates the frequency, rate or extent of protein oxidation. go.json regulation of protein amino acid oxidation http://purl.obolibrary.org/obo/GO_1904806 GO:1904805 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904805 GO:1904804 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904804 GO:1904803 biolink:BiologicalProcess regulation of translation involved in cellular response to UV Any regulation of translation that is involved in cellular response to UV. go.json regulation of protein anabolism involved in cellular response to UV|regulation of protein biosynthesis involved in cellular response to UV|regulation of protein formation involved in cellular response to UV|regulation of protein synthesis involved in cellular response to UV|regulation of translation involved in cellular response to UV light stimulus|regulation of translation involved in cellular response to UV radiation stimulus|regulation of translation involved in cellular response to ultraviolet light stimulus|regulation of translation involved in cellular response to ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_1904803 GO:1904802 biolink:BiologicalProcess RITS complex assembly The aggregation, arrangement and bonding together of a set of components to form a RITS complex. go.json RITS complex formation http://purl.obolibrary.org/obo/GO_1904802 GO:1904801 biolink:BiologicalProcess positive regulation of neuron remodeling Any process that activates or increases the frequency, rate or extent of neuron remodeling. go.json activation of axon pruning|activation of neuron remodeling|activation of neuronal remodeling|positive regulation of axon pruning|positive regulation of neuron remodelling|positive regulation of neuronal remodeling|up regulation of axon pruning|up regulation of neuron remodeling|up regulation of neuronal remodeling|up-regulation of axon pruning|up-regulation of neuron remodeling|up-regulation of neuronal remodeling|upregulation of axon pruning|upregulation of neuron remodeling|upregulation of neuronal remodeling http://purl.obolibrary.org/obo/GO_1904801 GO:1904800 biolink:BiologicalProcess negative regulation of neuron remodeling Any process that stops, prevents or reduces the frequency, rate or extent of neuron remodeling. go.json down regulation of axon pruning|down regulation of neuron remodeling|down regulation of neuronal remodeling|down-regulation of axon pruning|down-regulation of neuron remodeling|down-regulation of neuronal remodeling|downregulation of axon pruning|downregulation of neuron remodeling|downregulation of neuronal remodeling|inhibition of axon pruning|inhibition of neuron remodeling|inhibition of neuronal remodeling|negative regulation of axon pruning|negative regulation of neuron remodelling|negative regulation of neuronal remodeling http://purl.obolibrary.org/obo/GO_1904800 GO:1904819 biolink:BiologicalProcess parietal peritoneum development The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. go.json peritoneal cavity lining development http://purl.obolibrary.org/obo/GO_1904819 GO:1904818 biolink:BiologicalProcess visceral peritoneum development The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_1904818 GO:1904817 biolink:BiologicalProcess serous membrane development The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. go.json serosa development|tunica serosa development|wall of serous sac development http://purl.obolibrary.org/obo/GO_1904817 GO:1904816 biolink:BiologicalProcess positive regulation of protein localization to chromosome, telomeric region Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region. go.json activation of protein localisation to chromosome, telomeric region|activation of protein localization to chromosome, telomeric region|activation of protein localization to telomere|positive regulation of protein localisation to chromosome, telomeric region|positive regulation of protein localization to telomere|up regulation of protein localisation to chromosome, telomeric region|up regulation of protein localization to chromosome, telomeric region|up regulation of protein localization to telomere|up-regulation of protein localisation to chromosome, telomeric region|up-regulation of protein localization to chromosome, telomeric region|up-regulation of protein localization to telomere|upregulation of protein localisation to chromosome, telomeric region|upregulation of protein localization to chromosome, telomeric region|upregulation of protein localization to telomere http://purl.obolibrary.org/obo/GO_1904816 GO:1904815 biolink:BiologicalProcess negative regulation of protein localization to chromosome, telomeric region Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region. go.json down regulation of protein localisation to chromosome, telomeric region|down regulation of protein localization to chromosome, telomeric region|down regulation of protein localization to telomere|down-regulation of protein localisation to chromosome, telomeric region|down-regulation of protein localization to chromosome, telomeric region|down-regulation of protein localization to telomere|downregulation of protein localisation to chromosome, telomeric region|downregulation of protein localization to chromosome, telomeric region|downregulation of protein localization to telomere|inhibition of protein localisation to chromosome, telomeric region|inhibition of protein localization to chromosome, telomeric region|inhibition of protein localization to telomere|negative regulation of protein localisation to chromosome, telomeric region|negative regulation of protein localization to telomere http://purl.obolibrary.org/obo/GO_1904815 GO:1904814 biolink:BiologicalProcess regulation of protein localization to chromosome, telomeric region Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. go.json regulation of protein localisation to chromosome, telomeric region|regulation of protein localization to telomere http://purl.obolibrary.org/obo/GO_1904814 GO:1904813 biolink:CellularComponent ficolin-1-rich granule lumen Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. go.json ficolin-1-rich granule membrane-enclosed lumen|membrane-enclosed lumen of ficolin granule|membrane-enclosed lumen of ficolin-1 rich granule|membrane-enclosed lumen of ficolin-1-rich granule http://purl.obolibrary.org/obo/GO_1904813 GO:1904812 biolink:BiologicalProcess rRNA acetylation involved in maturation of SSU-rRNA Any rRNA acetylation that is involved in maturation of SSU-rRNA. go.json rRNA acetylation involved in SSU-rRNA maturation|rRNA acetylation involved in processing of 20S pre-rRNA http://purl.obolibrary.org/obo/GO_1904812 GO:1904811 biolink:BiologicalProcess positive regulation of dense core granule transport Any process that activates or increases the frequency, rate or extent of dense core granule transport. go.json activation of dense core granule transport|activation of dense core vesicle transport|positive regulation of dense core vesicle transport|up regulation of dense core granule transport|up regulation of dense core vesicle transport|up-regulation of dense core granule transport|up-regulation of dense core vesicle transport|upregulation of dense core granule transport|upregulation of dense core vesicle transport http://purl.obolibrary.org/obo/GO_1904811 GO:1904810 biolink:BiologicalProcess negative regulation of dense core granule transport Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport. go.json down regulation of dense core granule transport|down regulation of dense core vesicle transport|down-regulation of dense core granule transport|down-regulation of dense core vesicle transport|downregulation of dense core granule transport|downregulation of dense core vesicle transport|inhibition of dense core granule transport|inhibition of dense core vesicle transport|negative regulation of dense core vesicle transport http://purl.obolibrary.org/obo/GO_1904810 GO:1904829 biolink:BiologicalProcess regulation of aortic smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1904829 GO:1904828 biolink:BiologicalProcess positive regulation of hydrogen sulfide biosynthetic process Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process. go.json activation of hydrogen sulfide anabolism|activation of hydrogen sulfide biosynthesis|activation of hydrogen sulfide biosynthetic process|activation of hydrogen sulfide formation|activation of hydrogen sulfide synthesis|activation of hydrogen sulphide biosynthesis|activation of hydrogen sulphide biosynthetic process|positive regulation of hydrogen sulfide anabolism|positive regulation of hydrogen sulfide biosynthesis|positive regulation of hydrogen sulfide formation|positive regulation of hydrogen sulfide synthesis|positive regulation of hydrogen sulphide biosynthesis|positive regulation of hydrogen sulphide biosynthetic process|up regulation of hydrogen sulfide anabolism|up regulation of hydrogen sulfide biosynthesis|up regulation of hydrogen sulfide biosynthetic process|up regulation of hydrogen sulfide formation|up regulation of hydrogen sulfide synthesis|up regulation of hydrogen sulphide biosynthesis|up regulation of hydrogen sulphide biosynthetic process|up-regulation of hydrogen sulfide anabolism|up-regulation of hydrogen sulfide biosynthesis|up-regulation of hydrogen sulfide biosynthetic process|up-regulation of hydrogen sulfide formation|up-regulation of hydrogen sulfide synthesis|up-regulation of hydrogen sulphide biosynthesis|up-regulation of hydrogen sulphide biosynthetic process|upregulation of hydrogen sulfide anabolism|upregulation of hydrogen sulfide biosynthesis|upregulation of hydrogen sulfide biosynthetic process|upregulation of hydrogen sulfide formation|upregulation of hydrogen sulfide synthesis|upregulation of hydrogen sulphide biosynthesis|upregulation of hydrogen sulphide biosynthetic process http://purl.obolibrary.org/obo/GO_1904828 GO:1904827 biolink:BiologicalProcess negative regulation of hydrogen sulfide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen sulfide biosynthetic process. go.json down regulation of hydrogen sulfide anabolism|down regulation of hydrogen sulfide biosynthesis|down regulation of hydrogen sulfide biosynthetic process|down regulation of hydrogen sulfide formation|down regulation of hydrogen sulfide synthesis|down regulation of hydrogen sulphide biosynthesis|down regulation of hydrogen sulphide biosynthetic process|down-regulation of hydrogen sulfide anabolism|down-regulation of hydrogen sulfide biosynthesis|down-regulation of hydrogen sulfide biosynthetic process|down-regulation of hydrogen sulfide formation|down-regulation of hydrogen sulfide synthesis|down-regulation of hydrogen sulphide biosynthesis|down-regulation of hydrogen sulphide biosynthetic process|downregulation of hydrogen sulfide anabolism|downregulation of hydrogen sulfide biosynthesis|downregulation of hydrogen sulfide biosynthetic process|downregulation of hydrogen sulfide formation|downregulation of hydrogen sulfide synthesis|downregulation of hydrogen sulphide biosynthesis|downregulation of hydrogen sulphide biosynthetic process|inhibition of hydrogen sulfide anabolism|inhibition of hydrogen sulfide biosynthesis|inhibition of hydrogen sulfide biosynthetic process|inhibition of hydrogen sulfide formation|inhibition of hydrogen sulfide synthesis|inhibition of hydrogen sulphide biosynthesis|inhibition of hydrogen sulphide biosynthetic process|negative regulation of hydrogen sulfide anabolism|negative regulation of hydrogen sulfide biosynthesis|negative regulation of hydrogen sulfide formation|negative regulation of hydrogen sulfide synthesis|negative regulation of hydrogen sulphide biosynthesis|negative regulation of hydrogen sulphide biosynthetic process http://purl.obolibrary.org/obo/GO_1904827 GO:1904826 biolink:BiologicalProcess regulation of hydrogen sulfide biosynthetic process Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process. go.json regulation of hydrogen sulfide anabolism|regulation of hydrogen sulfide biosynthesis|regulation of hydrogen sulfide formation|regulation of hydrogen sulfide synthesis|regulation of hydrogen sulphide biosynthesis|regulation of hydrogen sulphide biosynthetic process http://purl.obolibrary.org/obo/GO_1904826 GO:1904825 biolink:BiologicalProcess protein localization to microtubule plus-end A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end. go.json protein localisation to microtubule plus-end http://purl.obolibrary.org/obo/GO_1904825 GO:1904824 biolink:BiologicalProcess anaphase-promoting complex assembly The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex. go.json APC assembly|anaphase promoting complex assembly|anaphase promoting complex formation|anaphase-promoting complex formation|cyclosome assembly|cyclosome formation http://purl.obolibrary.org/obo/GO_1904824 GO:1904823 biolink:BiologicalProcess purine nucleobase transmembrane transport The process in which a purine nucleobase is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904823 GO:1904822 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904822 GO:1904821 biolink:BiologicalProcess chloroplast disassembly The disaggregation of a chloroplast into its constituent components. go.json chloroplast degradation http://purl.obolibrary.org/obo/GO_1904821 GO:1904820 biolink:BiologicalProcess peritoneum development The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. go.json peritonaeum development http://purl.obolibrary.org/obo/GO_1904820 GO:1904799 biolink:BiologicalProcess regulation of neuron remodeling Any process that modulates the frequency, rate or extent of neuron remodeling. go.json regulation of axon pruning|regulation of neuron remodelling|regulation of neuronal remodeling http://purl.obolibrary.org/obo/GO_1904799 GO:1904798 biolink:BiologicalProcess positive regulation of core promoter binding Any process that activates or increases the frequency, rate or extent of core promoter binding. go.json activation of core promoter binding|up regulation of core promoter binding|up-regulation of core promoter binding|upregulation of core promoter binding http://purl.obolibrary.org/obo/GO_1904798 gocheck_do_not_annotate GO:1904797 biolink:BiologicalProcess negative regulation of core promoter binding Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding. go.json down regulation of core promoter binding|down-regulation of core promoter binding|downregulation of core promoter binding|inhibition of core promoter binding http://purl.obolibrary.org/obo/GO_1904797 gocheck_do_not_annotate GO:1904796 biolink:BiologicalProcess regulation of core promoter binding Any process that modulates the frequency, rate or extent of core promoter binding. go.json http://purl.obolibrary.org/obo/GO_1904796 gocheck_do_not_annotate GO:1904795 biolink:BiologicalProcess positive regulation of euchromatin binding Any process that activates or increases the frequency, rate or extent of euchromatin binding. go.json activation of euchromatin binding|up regulation of euchromatin binding|up-regulation of euchromatin binding|upregulation of euchromatin binding http://purl.obolibrary.org/obo/GO_1904795 gocheck_do_not_annotate RO:0019001 biolink:OntologyClass positively regulates characteristic RO:0019001 go.json http://purl.obolibrary.org/obo/RO_0019001 RO:0019000 biolink:OntologyClass regulates characteristic RO:0019000 go.json http://purl.obolibrary.org/obo/RO_0019000 RO:0019002 biolink:OntologyClass negatively regulates characteristic RO:0019002 go.json http://purl.obolibrary.org/obo/RO_0019002 GO:1904719 biolink:BiologicalProcess positive regulation of AMPA glutamate receptor clustering Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering. go.json activation of AMPA glutamate receptor clustering|activation of AMPA receptor clustering|activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|positive regulation of AMPA receptor clustering|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|up regulation of AMPA glutamate receptor clustering|up regulation of AMPA receptor clustering|up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|up-regulation of AMPA glutamate receptor clustering|up-regulation of AMPA receptor clustering|up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|upregulation of AMPA glutamate receptor clustering|upregulation of AMPA receptor clustering|upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering http://purl.obolibrary.org/obo/GO_1904719 GO:1904718 biolink:BiologicalProcess negative regulation of AMPA glutamate receptor clustering Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering. go.json down regulation of AMPA glutamate receptor clustering|down regulation of AMPA receptor clustering|down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|down-regulation of AMPA glutamate receptor clustering|down-regulation of AMPA receptor clustering|down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|downregulation of AMPA glutamate receptor clustering|downregulation of AMPA receptor clustering|downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|inhibition of AMPA glutamate receptor clustering|inhibition of AMPA receptor clustering|inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|negative regulation of AMPA receptor clustering|negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering http://purl.obolibrary.org/obo/GO_1904718 GO:1904717 biolink:BiologicalProcess regulation of AMPA glutamate receptor clustering Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering. go.json regulation of AMPA receptor clustering|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering http://purl.obolibrary.org/obo/GO_1904717 GO:1904716 biolink:BiologicalProcess positive regulation of chaperone-mediated autophagy Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy. go.json activation of CMA|activation of chaperone-mediated autophagy|positive regulation of CMA|up regulation of CMA|up regulation of chaperone-mediated autophagy|up-regulation of CMA|up-regulation of chaperone-mediated autophagy|upregulation of CMA|upregulation of chaperone-mediated autophagy http://purl.obolibrary.org/obo/GO_1904716 GO:1904715 biolink:BiologicalProcess negative regulation of chaperone-mediated autophagy Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy. go.json down regulation of CMA|down regulation of chaperone-mediated autophagy|down-regulation of CMA|down-regulation of chaperone-mediated autophagy|downregulation of CMA|downregulation of chaperone-mediated autophagy|inhibition of CMA|inhibition of chaperone-mediated autophagy|negative regulation of CMA http://purl.obolibrary.org/obo/GO_1904715 GO:1904714 biolink:BiologicalProcess regulation of chaperone-mediated autophagy Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy. go.json regulation of CMA http://purl.obolibrary.org/obo/GO_1904714 GO:1904713 biolink:MolecularActivity beta-catenin destruction complex binding Binding to a beta-catenin destruction complex. go.json 23S APC complex binding|APC-Axin-1-beta-catenin complex binding|Axin-APC-beta-catenin-GSK3B complex binding|BDC binding|beta-catenin degradation complex binding http://purl.obolibrary.org/obo/GO_1904713 GO:1904712 biolink:BiologicalProcess positive regulation of Wnt-Frizzled-LRP5/6 complex assembly Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. go.json activation of Frizzled-LRP5/6 complex assembly|activation of Frizzled-LRP5/6 complex formation|activation of WNT-FZD-LRP5 complex assembly|activation of WNT-FZD-LRP5 complex formation|activation of WNT-FZD-LRP6 complex assembly|activation of WNT-FZD-LRP6 complex formation|activation of Wnt-FZD-LRP5/6 trimeric complex assembly|activation of Wnt-FZD-LRP5/6 trimeric complex formation|activation of Wnt-induced Frizzled-LRP5/6 complex assembly|activation of Wnt-induced Frizzled-LRP5/6 complex formation|positive regulation of Frizzled-LRP5/6 complex assembly|positive regulation of Frizzled-LRP5/6 complex formation|positive regulation of WNT-FZD-LRP5 complex assembly|positive regulation of WNT-FZD-LRP5 complex formation|positive regulation of WNT-FZD-LRP6 complex assembly|positive regulation of WNT-FZD-LRP6 complex formation|positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation|positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation|up regulation of Frizzled-LRP5/6 complex assembly|up regulation of Frizzled-LRP5/6 complex formation|up regulation of WNT-FZD-LRP5 complex assembly|up regulation of WNT-FZD-LRP5 complex formation|up regulation of WNT-FZD-LRP6 complex assembly|up regulation of WNT-FZD-LRP6 complex formation|up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|up regulation of Wnt-FZD-LRP5/6 trimeric complex formation|up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|up regulation of Wnt-induced Frizzled-LRP5/6 complex formation|up-regulation of Frizzled-LRP5/6 complex assembly|up-regulation of Frizzled-LRP5/6 complex formation|up-regulation of WNT-FZD-LRP5 complex assembly|up-regulation of WNT-FZD-LRP5 complex formation|up-regulation of WNT-FZD-LRP6 complex assembly|up-regulation of WNT-FZD-LRP6 complex formation|up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation|up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation|upregulation of Frizzled-LRP5/6 complex assembly|upregulation of Frizzled-LRP5/6 complex formation|upregulation of WNT-FZD-LRP5 complex assembly|upregulation of WNT-FZD-LRP5 complex formation|upregulation of WNT-FZD-LRP6 complex assembly|upregulation of WNT-FZD-LRP6 complex formation|upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly|upregulation of Wnt-FZD-LRP5/6 trimeric complex formation|upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly|upregulation of Wnt-induced Frizzled-LRP5/6 complex formation http://purl.obolibrary.org/obo/GO_1904712 GO:1904711 biolink:BiologicalProcess regulation of Wnt-Frizzled-LRP5/6 complex assembly Any process that modulates the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. go.json regulation of Frizzled-LRP5/6 complex assembly|regulation of Frizzled-LRP5/6 complex formation|regulation of WNT-FZD-LRP5 complex assembly|regulation of WNT-FZD-LRP5 complex formation|regulation of WNT-FZD-LRP6 complex assembly|regulation of WNT-FZD-LRP6 complex formation|regulation of Wnt receptor complex assembly|regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|regulation of Wnt-FZD-LRP5/6 trimeric complex formation|regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|regulation of Wnt-induced Frizzled-LRP5/6 complex formation http://purl.obolibrary.org/obo/GO_1904711 GO:1904710 biolink:BiologicalProcess positive regulation of granulosa cell apoptotic process Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process. go.json activation of granulosa cell apoptosis|activation of granulosa cell apoptotic process|activation of granulosa cell of ovary apoptosis|activation of granulosa cell of ovary apoptotic process|positive regulation of granulosa cell apoptosis|positive regulation of granulosa cell of ovary apoptosis|positive regulation of granulosa cell of ovary apoptotic process|up regulation of granulosa cell apoptosis|up regulation of granulosa cell apoptotic process|up regulation of granulosa cell of ovary apoptosis|up regulation of granulosa cell of ovary apoptotic process|up-regulation of granulosa cell apoptosis|up-regulation of granulosa cell apoptotic process|up-regulation of granulosa cell of ovary apoptosis|up-regulation of granulosa cell of ovary apoptotic process|upregulation of granulosa cell apoptosis|upregulation of granulosa cell apoptotic process|upregulation of granulosa cell of ovary apoptosis|upregulation of granulosa cell of ovary apoptotic process http://purl.obolibrary.org/obo/GO_1904710 GO:1904729 biolink:BiologicalProcess regulation of intestinal lipid absorption Any process that modulates the frequency, rate or extent of intestinal lipid absorption. go.json http://purl.obolibrary.org/obo/GO_1904729 GO:1904728 biolink:BiologicalProcess positive regulation of replicative senescence Any process that activates or increases the frequency, rate or extent of replicative senescence. go.json activation of replicative senescence|up regulation of replicative senescence|up-regulation of replicative senescence|upregulation of replicative senescence http://purl.obolibrary.org/obo/GO_1904728 GO:1904727 biolink:BiologicalProcess negative regulation of replicative senescence Any process that stops, prevents or reduces the frequency, rate or extent of replicative senescence. go.json down regulation of replicative senescence|down-regulation of replicative senescence|downregulation of replicative senescence|inhibition of replicative senescence http://purl.obolibrary.org/obo/GO_1904727 GO:1904726 biolink:BiologicalProcess regulation of replicative senescence Any process that modulates the frequency, rate or extent of replicative senescence. go.json http://purl.obolibrary.org/obo/GO_1904726 GO:1904725 biolink:MolecularActivity obsolete TFIIB-class transcription factor binding involved in negative regulation of transcription OBSOLETE. Any TFIIB-class transcription factor binding that is involved in negative regulation of DNA-templated transcription. go.json TFIIB-class transcription factor binding involved in down regulation of gene-specific transcription|TFIIB-class transcription factor binding involved in down regulation of transcription, DNA-dependent|TFIIB-class transcription factor binding involved in down-regulation of gene-specific transcription|TFIIB-class transcription factor binding involved in down-regulation of transcription, DNA-dependent|TFIIB-class transcription factor binding involved in downregulation of gene-specific transcription|TFIIB-class transcription factor binding involved in downregulation of transcription, DNA-dependent|TFIIB-class transcription factor binding involved in inhibition of gene-specific transcription|TFIIB-class transcription factor binding involved in inhibition of transcription, DNA-dependent|TFIIB-class transcription factor binding involved in negative regulation of cellular transcription, DNA-dependent|TFIIB-class transcription factor binding involved in negative regulation of gene-specific transcription|TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-dependent|TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-templated|TFIIB-class transcription factor binding involved in transcription repressor activity True http://purl.obolibrary.org/obo/GO_1904725 GO:1904724 biolink:CellularComponent tertiary granule lumen Any membrane-enclosed lumen that is part of a tertiary granule. go.json gelatinase granule membrane-enclosed lumen|membrane-enclosed lumen of gelatinase granule|membrane-enclosed lumen of tertiary granule|tertiary granule membrane-enclosed lumen http://purl.obolibrary.org/obo/GO_1904724 GO:1904723 biolink:BiologicalProcess negative regulation of Wnt-Frizzled-LRP5/6 complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. go.json down regulation of Frizzled-LRP5/6 complex assembly|down regulation of Frizzled-LRP5/6 complex formation|down regulation of WNT-FZD-LRP5 complex assembly|down regulation of WNT-FZD-LRP5 complex formation|down regulation of WNT-FZD-LRP6 complex assembly|down regulation of WNT-FZD-LRP6 complex formation|down regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|down regulation of Wnt-FZD-LRP5/6 trimeric complex formation|down regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|down regulation of Wnt-induced Frizzled-LRP5/6 complex formation|down-regulation of Frizzled-LRP5/6 complex assembly|down-regulation of Frizzled-LRP5/6 complex formation|down-regulation of WNT-FZD-LRP5 complex assembly|down-regulation of WNT-FZD-LRP5 complex formation|down-regulation of WNT-FZD-LRP6 complex assembly|down-regulation of WNT-FZD-LRP6 complex formation|down-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|down-regulation of Wnt-FZD-LRP5/6 trimeric complex formation|down-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|down-regulation of Wnt-induced Frizzled-LRP5/6 complex formation|downregulation of Frizzled-LRP5/6 complex assembly|downregulation of Frizzled-LRP5/6 complex formation|downregulation of WNT-FZD-LRP5 complex assembly|downregulation of WNT-FZD-LRP5 complex formation|downregulation of WNT-FZD-LRP6 complex assembly|downregulation of WNT-FZD-LRP6 complex formation|downregulation of Wnt-FZD-LRP5/6 trimeric complex assembly|downregulation of Wnt-FZD-LRP5/6 trimeric complex formation|downregulation of Wnt-induced Frizzled-LRP5/6 complex assembly|downregulation of Wnt-induced Frizzled-LRP5/6 complex formation|inhibition of Frizzled-LRP5/6 complex assembly|inhibition of Frizzled-LRP5/6 complex formation|inhibition of WNT-FZD-LRP5 complex assembly|inhibition of WNT-FZD-LRP5 complex formation|inhibition of WNT-FZD-LRP6 complex assembly|inhibition of WNT-FZD-LRP6 complex formation|inhibition of Wnt-FZD-LRP5/6 trimeric complex assembly|inhibition of Wnt-FZD-LRP5/6 trimeric complex formation|inhibition of Wnt-induced Frizzled-LRP5/6 complex assembly|inhibition of Wnt-induced Frizzled-LRP5/6 complex formation|negative regulation of Frizzled-LRP5/6 complex assembly|negative regulation of Frizzled-LRP5/6 complex formation|negative regulation of WNT-FZD-LRP5 complex assembly|negative regulation of WNT-FZD-LRP5 complex formation|negative regulation of WNT-FZD-LRP6 complex assembly|negative regulation of WNT-FZD-LRP6 complex formation|negative regulation of Wnt-FZD-LRP5/6 trimeric complex assembly|negative regulation of Wnt-FZD-LRP5/6 trimeric complex formation|negative regulation of Wnt-induced Frizzled-LRP5/6 complex assembly|negative regulation of Wnt-induced Frizzled-LRP5/6 complex formation http://purl.obolibrary.org/obo/GO_1904723 GO:1904722 biolink:BiologicalProcess obsolete positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response. go.json activation of HAC1 mRNA cleavage|activation of HAC1-type intron splice site recognition and cleavage|activation of IRE1-mediated XBP-1 mRNA cleavage|activation of XBP1 mRNA cleavage|activation of mRNA endonucleolytic cleavage involved in unfolded protein response|positive regulation of HAC1 mRNA cleavage|positive regulation of HAC1-type intron splice site recognition and cleavage|positive regulation of IRE1-mediated XBP-1 mRNA cleavage|positive regulation of XBP1 mRNA cleavage|up regulation of HAC1 mRNA cleavage|up regulation of HAC1-type intron splice site recognition and cleavage|up regulation of IRE1-mediated XBP-1 mRNA cleavage|up regulation of XBP1 mRNA cleavage|up regulation of mRNA endonucleolytic cleavage involved in unfolded protein response|up-regulation of HAC1 mRNA cleavage|up-regulation of HAC1-type intron splice site recognition and cleavage|up-regulation of IRE1-mediated XBP-1 mRNA cleavage|up-regulation of XBP1 mRNA cleavage|up-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response|upregulation of HAC1 mRNA cleavage|upregulation of HAC1-type intron splice site recognition and cleavage|upregulation of IRE1-mediated XBP-1 mRNA cleavage|upregulation of XBP1 mRNA cleavage|upregulation of mRNA endonucleolytic cleavage involved in unfolded protein response True http://purl.obolibrary.org/obo/GO_1904722 GO:1904721 biolink:BiologicalProcess obsolete negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response. go.json down regulation of HAC1 mRNA cleavage|down regulation of HAC1-type intron splice site recognition and cleavage|down regulation of IRE1-mediated XBP-1 mRNA cleavage|down regulation of XBP1 mRNA cleavage|down regulation of mRNA endonucleolytic cleavage involved in unfolded protein response|down-regulation of HAC1 mRNA cleavage|down-regulation of HAC1-type intron splice site recognition and cleavage|down-regulation of IRE1-mediated XBP-1 mRNA cleavage|down-regulation of XBP1 mRNA cleavage|down-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response|downregulation of HAC1 mRNA cleavage|downregulation of HAC1-type intron splice site recognition and cleavage|downregulation of IRE1-mediated XBP-1 mRNA cleavage|downregulation of XBP1 mRNA cleavage|downregulation of mRNA endonucleolytic cleavage involved in unfolded protein response|inhibition of HAC1 mRNA cleavage|inhibition of HAC1-type intron splice site recognition and cleavage|inhibition of IRE1-mediated XBP-1 mRNA cleavage|inhibition of XBP1 mRNA cleavage|inhibition of mRNA endonucleolytic cleavage involved in unfolded protein response|negative regulation of HAC1 mRNA cleavage|negative regulation of HAC1-type intron splice site recognition and cleavage|negative regulation of IRE1-mediated XBP-1 mRNA cleavage|negative regulation of XBP1 mRNA cleavage True http://purl.obolibrary.org/obo/GO_1904721 GO:1904720 biolink:BiologicalProcess obsolete regulation of mRNA endonucleolytic cleavage involved in unfolded protein response OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response. go.json regulation of HAC1 mRNA cleavage|regulation of HAC1-type intron splice site recognition and cleavage|regulation of IRE1-mediated XBP-1 mRNA cleavage|regulation of XBP1 mRNA cleavage True http://purl.obolibrary.org/obo/GO_1904720 GO:1904739 biolink:BiologicalProcess obsolete regulation of synapse organization by posttranscriptional regulation of gene expression OBSOLETE. A posttranscriptional regulation of gene expression that results in regulation of synapse organization. go.json regulation of synapse development by posttranscriptional regulation of gene expression|regulation of synapse morphogenesis by posttranscriptional regulation of gene expression|regulation of synapse organisation by posttranscriptional regulation of gene expression|regulation of synapse organization and biogenesis by posttranscriptional regulation of gene expression True http://purl.obolibrary.org/obo/GO_1904739 GO:1904738 biolink:BiologicalProcess vascular associated smooth muscle cell migration The orderly movement of a vascular associated smooth muscle cell from one site to another. go.json vascular smooth muscle cell migration http://purl.obolibrary.org/obo/GO_1904738 GO:1904737 biolink:BiologicalProcess positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase. go.json activation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|up regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|up-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|upregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase http://purl.obolibrary.org/obo/GO_1904737 GO:1904736 biolink:BiologicalProcess negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase. go.json down regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|down-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|downregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|inhibition of fatty acid beta-oxidation using acyl-CoA dehydrogenase http://purl.obolibrary.org/obo/GO_1904736 GO:1904735 biolink:BiologicalProcess regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase. go.json http://purl.obolibrary.org/obo/GO_1904735 GO:1904734 biolink:BiologicalProcess positive regulation of electron transfer activity Any process that activates or increases the frequency, rate or extent of electron transfer activity. go.json activation of 2Fe-2S electron transfer carrier|activation of 3Fe-4S/4Fe-4S electron transfer carrier|activation of adrenodoxin-type ferredoxin|activation of amicyanin|activation of azurin|activation of bacterial-type ferredoxin|activation of chloroplast-type ferredoxin|activation of copper electron carrier|activation of dicluster bacterial-type ferredoxin|activation of electron acceptor activity|activation of electron carrier activity|activation of electron carrier, chlorophyll electron transport system|activation of electron donor activity|activation of electron transfer flavoprotein|activation of electron transfer flavoprotein, group I|activation of electron transfer flavoprotein, group II|activation of electron transporter activity|activation of high-potential iron-sulfur carrier|activation of iron-sulfur electron transfer carrier|activation of monocluster bacterial-type ferredoxin|activation of mononuclear iron electron carrier|activation of polyferredoxin|activation of redox-active disulfide bond electron carrier|activation of rubredoxin|activation of small blue copper electron carrier|activation of thioredoxin-like 2Fe-2S ferredoxin|positive regulation of 2Fe-2S electron transfer carrier|positive regulation of 3Fe-4S/4Fe-4S electron transfer carrier|positive regulation of adrenodoxin-type ferredoxin|positive regulation of amicyanin|positive regulation of azurin|positive regulation of bacterial-type ferredoxin|positive regulation of chloroplast-type ferredoxin|positive regulation of copper electron carrier|positive regulation of dicluster bacterial-type ferredoxin|positive regulation of electron acceptor activity|positive regulation of electron carrier, chlorophyll electron transport system|positive regulation of electron donor activity|positive regulation of electron transfer flavoprotein|positive regulation of electron transfer flavoprotein, group I|positive regulation of electron transfer flavoprotein, group II|positive regulation of electron transporter activity|positive regulation of high-potential iron-sulfur carrier|positive regulation of iron-sulfur electron transfer carrier|positive regulation of monocluster bacterial-type ferredoxin|positive regulation of mononuclear iron electron carrier|positive regulation of polyferredoxin|positive regulation of redox-active disulfide bond electron carrier|positive regulation of rubredoxin|positive regulation of small blue copper electron carrier|positive regulation of thioredoxin-like 2Fe-2S ferredoxin|up regulation of 2Fe-2S electron transfer carrier|up regulation of 3Fe-4S/4Fe-4S electron transfer carrier|up regulation of adrenodoxin-type ferredoxin|up regulation of amicyanin|up regulation of azurin|up regulation of bacterial-type ferredoxin|up regulation of chloroplast-type ferredoxin|up regulation of copper electron carrier|up regulation of dicluster bacterial-type ferredoxin|up regulation of electron acceptor activity|up regulation of electron carrier activity|up regulation of electron carrier, chlorophyll electron transport system|up regulation of electron donor activity|up regulation of electron transfer flavoprotein|up regulation of electron transfer flavoprotein, group I|up regulation of electron transfer flavoprotein, group II|up regulation of electron transporter activity|up regulation of high-potential iron-sulfur carrier|up regulation of iron-sulfur electron transfer carrier|up regulation of monocluster bacterial-type ferredoxin|up regulation of mononuclear iron electron carrier|up regulation of polyferredoxin|up regulation of redox-active disulfide bond electron carrier|up regulation of rubredoxin|up regulation of small blue copper electron carrier|up regulation of thioredoxin-like 2Fe-2S ferredoxin|up-regulation of 2Fe-2S electron transfer carrier|up-regulation of 3Fe-4S/4Fe-4S electron transfer carrier|up-regulation of adrenodoxin-type ferredoxin|up-regulation of amicyanin|up-regulation of azurin|up-regulation of bacterial-type ferredoxin|up-regulation of chloroplast-type ferredoxin|up-regulation of copper electron carrier|up-regulation of dicluster bacterial-type ferredoxin|up-regulation of electron acceptor activity|up-regulation of electron carrier activity|up-regulation of electron carrier, chlorophyll electron transport system|up-regulation of electron donor activity|up-regulation of electron transfer flavoprotein|up-regulation of electron transfer flavoprotein, group I|up-regulation of electron transfer flavoprotein, group II|up-regulation of electron transporter activity|up-regulation of high-potential iron-sulfur carrier|up-regulation of iron-sulfur electron transfer carrier|up-regulation of monocluster bacterial-type ferredoxin|up-regulation of mononuclear iron electron carrier|up-regulation of polyferredoxin|up-regulation of redox-active disulfide bond electron carrier|up-regulation of rubredoxin|up-regulation of small blue copper electron carrier|up-regulation of thioredoxin-like 2Fe-2S ferredoxin|upregulation of 2Fe-2S electron transfer carrier|upregulation of 3Fe-4S/4Fe-4S electron transfer carrier|upregulation of adrenodoxin-type ferredoxin|upregulation of amicyanin|upregulation of azurin|upregulation of bacterial-type ferredoxin|upregulation of chloroplast-type ferredoxin|upregulation of copper electron carrier|upregulation of dicluster bacterial-type ferredoxin|upregulation of electron acceptor activity|upregulation of electron carrier activity|upregulation of electron carrier, chlorophyll electron transport system|upregulation of electron donor activity|upregulation of electron transfer flavoprotein|upregulation of electron transfer flavoprotein, group I|upregulation of electron transfer flavoprotein, group II|upregulation of electron transporter activity|upregulation of high-potential iron-sulfur carrier|upregulation of iron-sulfur electron transfer carrier|upregulation of monocluster bacterial-type ferredoxin|upregulation of mononuclear iron electron carrier|upregulation of polyferredoxin|upregulation of redox-active disulfide bond electron carrier|upregulation of rubredoxin|upregulation of small blue copper electron carrier|upregulation of thioredoxin-like 2Fe-2S ferredoxin http://purl.obolibrary.org/obo/GO_1904734 gocheck_do_not_annotate GO:1904733 biolink:BiologicalProcess negative regulation of electron transfer activity Any process that stops, prevents or reduces the frequency, rate or extent of electron transfer activity. go.json down regulation of 2Fe-2S electron transfer carrier|down regulation of 3Fe-4S/4Fe-4S electron transfer carrier|down regulation of adrenodoxin-type ferredoxin|down regulation of amicyanin|down regulation of azurin|down regulation of bacterial-type ferredoxin|down regulation of chloroplast-type ferredoxin|down regulation of copper electron carrier|down regulation of dicluster bacterial-type ferredoxin|down regulation of electron acceptor activity|down regulation of electron carrier activity|down regulation of electron carrier, chlorophyll electron transport system|down regulation of electron donor activity|down regulation of electron transfer flavoprotein|down regulation of electron transfer flavoprotein, group I|down regulation of electron transfer flavoprotein, group II|down regulation of electron transporter activity|down regulation of high-potential iron-sulfur carrier|down regulation of iron-sulfur electron transfer carrier|down regulation of monocluster bacterial-type ferredoxin|down regulation of mononuclear iron electron carrier|down regulation of polyferredoxin|down regulation of redox-active disulfide bond electron carrier|down regulation of rubredoxin|down regulation of small blue copper electron carrier|down regulation of thioredoxin-like 2Fe-2S ferredoxin|down-regulation of 2Fe-2S electron transfer carrier|down-regulation of 3Fe-4S/4Fe-4S electron transfer carrier|down-regulation of adrenodoxin-type ferredoxin|down-regulation of amicyanin|down-regulation of azurin|down-regulation of bacterial-type ferredoxin|down-regulation of chloroplast-type ferredoxin|down-regulation of copper electron carrier|down-regulation of dicluster bacterial-type ferredoxin|down-regulation of electron acceptor activity|down-regulation of electron carrier activity|down-regulation of electron carrier, chlorophyll electron transport system|down-regulation of electron donor activity|down-regulation of electron transfer flavoprotein|down-regulation of electron transfer flavoprotein, group I|down-regulation of electron transfer flavoprotein, group II|down-regulation of electron transporter activity|down-regulation of high-potential iron-sulfur carrier|down-regulation of iron-sulfur electron transfer carrier|down-regulation of monocluster bacterial-type ferredoxin|down-regulation of mononuclear iron electron carrier|down-regulation of polyferredoxin|down-regulation of redox-active disulfide bond electron carrier|down-regulation of rubredoxin|down-regulation of small blue copper electron carrier|down-regulation of thioredoxin-like 2Fe-2S ferredoxin|downregulation of 2Fe-2S electron transfer carrier|downregulation of 3Fe-4S/4Fe-4S electron transfer carrier|downregulation of adrenodoxin-type ferredoxin|downregulation of amicyanin|downregulation of azurin|downregulation of bacterial-type ferredoxin|downregulation of chloroplast-type ferredoxin|downregulation of copper electron carrier|downregulation of dicluster bacterial-type ferredoxin|downregulation of electron acceptor activity|downregulation of electron carrier activity|downregulation of electron carrier, chlorophyll electron transport system|downregulation of electron donor activity|downregulation of electron transfer flavoprotein|downregulation of electron transfer flavoprotein, group I|downregulation of electron transfer flavoprotein, group II|downregulation of electron transporter activity|downregulation of high-potential iron-sulfur carrier|downregulation of iron-sulfur electron transfer carrier|downregulation of monocluster bacterial-type ferredoxin|downregulation of mononuclear iron electron carrier|downregulation of polyferredoxin|downregulation of redox-active disulfide bond electron carrier|downregulation of rubredoxin|downregulation of small blue copper electron carrier|downregulation of thioredoxin-like 2Fe-2S ferredoxin|inhibition of 2Fe-2S electron transfer carrier|inhibition of 3Fe-4S/4Fe-4S electron transfer carrier|inhibition of adrenodoxin-type ferredoxin|inhibition of amicyanin|inhibition of azurin|inhibition of bacterial-type ferredoxin|inhibition of chloroplast-type ferredoxin|inhibition of copper electron carrier|inhibition of dicluster bacterial-type ferredoxin|inhibition of electron acceptor activity|inhibition of electron carrier activity|inhibition of electron carrier, chlorophyll electron transport system|inhibition of electron donor activity|inhibition of electron transfer flavoprotein|inhibition of electron transfer flavoprotein, group I|inhibition of electron transfer flavoprotein, group II|inhibition of electron transporter activity|inhibition of high-potential iron-sulfur carrier|inhibition of iron-sulfur electron transfer carrier|inhibition of monocluster bacterial-type ferredoxin|inhibition of mononuclear iron electron carrier|inhibition of polyferredoxin|inhibition of redox-active disulfide bond electron carrier|inhibition of rubredoxin|inhibition of small blue copper electron carrier|inhibition of thioredoxin-like 2Fe-2S ferredoxin|negative regulation of 2Fe-2S electron transfer carrier|negative regulation of 3Fe-4S/4Fe-4S electron transfer carrier|negative regulation of adrenodoxin-type ferredoxin|negative regulation of amicyanin|negative regulation of azurin|negative regulation of bacterial-type ferredoxin|negative regulation of chloroplast-type ferredoxin|negative regulation of copper electron carrier|negative regulation of dicluster bacterial-type ferredoxin|negative regulation of electron acceptor activity|negative regulation of electron carrier, chlorophyll electron transport system|negative regulation of electron donor activity|negative regulation of electron transfer flavoprotein|negative regulation of electron transfer flavoprotein, group I|negative regulation of electron transfer flavoprotein, group II|negative regulation of electron transporter activity|negative regulation of high-potential iron-sulfur carrier|negative regulation of iron-sulfur electron transfer carrier|negative regulation of monocluster bacterial-type ferredoxin|negative regulation of mononuclear iron electron carrier|negative regulation of polyferredoxin|negative regulation of redox-active disulfide bond electron carrier|negative regulation of rubredoxin|negative regulation of small blue copper electron carrier|negative regulation of thioredoxin-like 2Fe-2S ferredoxin http://purl.obolibrary.org/obo/GO_1904733 gocheck_do_not_annotate GO:1904732 biolink:BiologicalProcess regulation of electron transfer activity Any process that modulates the frequency, rate or extent of electron transfer activity. go.json regulation of 2Fe-2S electron transfer carrier|regulation of 3Fe-4S/4Fe-4S electron transfer carrier|regulation of adrenodoxin-type ferredoxin|regulation of amicyanin|regulation of azurin|regulation of bacterial-type ferredoxin|regulation of chloroplast-type ferredoxin|regulation of copper electron carrier|regulation of dicluster bacterial-type ferredoxin|regulation of electron acceptor activity|regulation of electron carrier, chlorophyll electron transport system|regulation of electron donor activity|regulation of electron transfer flavoprotein|regulation of electron transfer flavoprotein, group I|regulation of electron transfer flavoprotein, group II|regulation of electron transporter activity|regulation of high-potential iron-sulfur carrier|regulation of iron-sulfur electron transfer carrier|regulation of monocluster bacterial-type ferredoxin|regulation of mononuclear iron electron carrier|regulation of polyferredoxin|regulation of redox-active disulfide bond electron carrier|regulation of rubredoxin|regulation of small blue copper electron carrier|regulation of thioredoxin-like 2Fe-2S ferredoxin http://purl.obolibrary.org/obo/GO_1904732 gocheck_do_not_annotate GO:1904731 biolink:BiologicalProcess positive regulation of intestinal lipid absorption Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption. go.json activation of intestinal lipid absorption|up regulation of intestinal lipid absorption|up-regulation of intestinal lipid absorption|upregulation of intestinal lipid absorption http://purl.obolibrary.org/obo/GO_1904731 GO:1904730 biolink:BiologicalProcess negative regulation of intestinal lipid absorption Any process that stops, prevents or reduces the frequency, rate or extent of intestinal lipid absorption. go.json down regulation of intestinal lipid absorption|down-regulation of intestinal lipid absorption|downregulation of intestinal lipid absorption|inhibition of intestinal lipid absorption http://purl.obolibrary.org/obo/GO_1904730 GO:1904749 biolink:BiologicalProcess regulation of protein localization to nucleolus Any process that modulates the frequency, rate or extent of protein localization to nucleolus. go.json regulation of protein localisation in nucleolus|regulation of protein localisation to nucleolus|regulation of protein localization in nucleolus http://purl.obolibrary.org/obo/GO_1904749 GO:1904748 biolink:BiologicalProcess regulation of apoptotic process involved in development Any process that modulates the frequency, rate or extent of apoptotic process involved in development. go.json regulation of activation of apoptosis involved in anatomical structure development|regulation of activation of apoptosis involved in development of an anatomical structure|regulation of apoptosis activator activity involved in anatomical structure development|regulation of apoptosis activator activity involved in development of an anatomical structure|regulation of apoptosis involved in anatomical structure development|regulation of apoptosis involved in development of an anatomical structure|regulation of apoptosis signaling involved in anatomical structure development|regulation of apoptosis signaling involved in development of an anatomical structure|regulation of apoptotic cell death involved in anatomical structure development|regulation of apoptotic cell death involved in development of an anatomical structure|regulation of apoptotic process involved in anatomical structure development|regulation of apoptotic process involved in development of an anatomical structure|regulation of apoptotic program involved in anatomical structure development|regulation of apoptotic program involved in development of an anatomical structure|regulation of apoptotic programmed cell death involved in anatomical structure development|regulation of apoptotic programmed cell death involved in development of an anatomical structure|regulation of commitment to apoptosis involved in anatomical structure development|regulation of commitment to apoptosis involved in development of an anatomical structure|regulation of induction of apoptosis by p53 involved in anatomical structure development|regulation of induction of apoptosis by p53 involved in development of an anatomical structure|regulation of induction of apoptosis involved in anatomical structure development|regulation of induction of apoptosis involved in development of an anatomical structure|regulation of programmed cell death by apoptosis involved in anatomical structure development|regulation of programmed cell death by apoptosis involved in development of an anatomical structure|regulation of signaling (initiator) caspase activity involved in anatomical structure development|regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|regulation of type I programmed cell death involved in anatomical structure development|regulation of type I programmed cell death involved in development of an anatomical structure http://purl.obolibrary.org/obo/GO_1904748 GO:1904747 biolink:BiologicalProcess positive regulation of apoptotic process involved in development Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. go.json activation of activation of apoptosis involved in anatomical structure development|activation of activation of apoptosis involved in development of an anatomical structure|activation of apoptosis activator activity involved in anatomical structure development|activation of apoptosis activator activity involved in development of an anatomical structure|activation of apoptosis involved in anatomical structure development|activation of apoptosis involved in development of an anatomical structure|activation of apoptosis signaling involved in anatomical structure development|activation of apoptosis signaling involved in development of an anatomical structure|activation of apoptotic cell death involved in anatomical structure development|activation of apoptotic cell death involved in development of an anatomical structure|activation of apoptotic process involved in anatomical structure development|activation of apoptotic process involved in development|activation of apoptotic process involved in development of an anatomical structure|activation of apoptotic program involved in anatomical structure development|activation of apoptotic program involved in development of an anatomical structure|activation of apoptotic programmed cell death involved in anatomical structure development|activation of apoptotic programmed cell death involved in development of an anatomical structure|activation of commitment to apoptosis involved in anatomical structure development|activation of commitment to apoptosis involved in development of an anatomical structure|activation of induction of apoptosis by p53 involved in anatomical structure development|activation of induction of apoptosis by p53 involved in development of an anatomical structure|activation of induction of apoptosis involved in anatomical structure development|activation of induction of apoptosis involved in development of an anatomical structure|activation of programmed cell death by apoptosis involved in anatomical structure development|activation of programmed cell death by apoptosis involved in development of an anatomical structure|activation of signaling (initiator) caspase activity involved in anatomical structure development|activation of signaling (initiator) caspase activity involved in development of an anatomical structure|activation of type I programmed cell death involved in anatomical structure development|activation of type I programmed cell death involved in development of an anatomical structure|positive regulation of activation of apoptosis involved in anatomical structure development|positive regulation of activation of apoptosis involved in development of an anatomical structure|positive regulation of apoptosis activator activity involved in anatomical structure development|positive regulation of apoptosis activator activity involved in development of an anatomical structure|positive regulation of apoptosis involved in anatomical structure development|positive regulation of apoptosis involved in development of an anatomical structure|positive regulation of apoptosis signaling involved in anatomical structure development|positive regulation of apoptosis signaling involved in development of an anatomical structure|positive regulation of apoptotic cell death involved in anatomical structure development|positive regulation of apoptotic cell death involved in development of an anatomical structure|positive regulation of apoptotic process involved in anatomical structure development|positive regulation of apoptotic process involved in development of an anatomical structure|positive regulation of apoptotic program involved in anatomical structure development|positive regulation of apoptotic program involved in development of an anatomical structure|positive regulation of apoptotic programmed cell death involved in anatomical structure development|positive regulation of apoptotic programmed cell death involved in development of an anatomical structure|positive regulation of commitment to apoptosis involved in anatomical structure development|positive regulation of commitment to apoptosis involved in development of an anatomical structure|positive regulation of induction of apoptosis by p53 involved in anatomical structure development|positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure|positive regulation of induction of apoptosis involved in anatomical structure development|positive regulation of induction of apoptosis involved in development of an anatomical structure|positive regulation of programmed cell death by apoptosis involved in anatomical structure development|positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure|positive regulation of signaling (initiator) caspase activity involved in anatomical structure development|positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|positive regulation of type I programmed cell death involved in anatomical structure development|positive regulation of type I programmed cell death involved in development of an anatomical structure|up regulation of activation of apoptosis involved in anatomical structure development|up regulation of activation of apoptosis involved in development of an anatomical structure|up regulation of apoptosis activator activity involved in anatomical structure development|up regulation of apoptosis activator activity involved in development of an anatomical structure|up regulation of apoptosis involved in anatomical structure development|up regulation of apoptosis involved in development of an anatomical structure|up regulation of apoptosis signaling involved in anatomical structure development|up regulation of apoptosis signaling involved in development of an anatomical structure|up regulation of apoptotic cell death involved in anatomical structure development|up regulation of apoptotic cell death involved in development of an anatomical structure|up regulation of apoptotic process involved in anatomical structure development|up regulation of apoptotic process involved in development|up regulation of apoptotic process involved in development of an anatomical structure|up regulation of apoptotic program involved in anatomical structure development|up regulation of apoptotic program involved in development of an anatomical structure|up regulation of apoptotic programmed cell death involved in anatomical structure development|up regulation of apoptotic programmed cell death involved in development of an anatomical structure|up regulation of commitment to apoptosis involved in anatomical structure development|up regulation of commitment to apoptosis involved in development of an anatomical structure|up regulation of induction of apoptosis by p53 involved in anatomical structure development|up regulation of induction of apoptosis by p53 involved in development of an anatomical structure|up regulation of induction of apoptosis involved in anatomical structure development|up regulation of induction of apoptosis involved in development of an anatomical structure|up regulation of programmed cell death by apoptosis involved in anatomical structure development|up regulation of programmed cell death by apoptosis involved in development of an anatomical structure|up regulation of signaling (initiator) caspase activity involved in anatomical structure development|up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|up regulation of type I programmed cell death involved in anatomical structure development|up regulation of type I programmed cell death involved in development of an anatomical structure|up-regulation of activation of apoptosis involved in anatomical structure development|up-regulation of activation of apoptosis involved in development of an anatomical structure|up-regulation of apoptosis activator activity involved in anatomical structure development|up-regulation of apoptosis activator activity involved in development of an anatomical structure|up-regulation of apoptosis involved in anatomical structure development|up-regulation of apoptosis involved in development of an anatomical structure|up-regulation of apoptosis signaling involved in anatomical structure development|up-regulation of apoptosis signaling involved in development of an anatomical structure|up-regulation of apoptotic cell death involved in anatomical structure development|up-regulation of apoptotic cell death involved in development of an anatomical structure|up-regulation of apoptotic process involved in anatomical structure development|up-regulation of apoptotic process involved in development|up-regulation of apoptotic process involved in development of an anatomical structure|up-regulation of apoptotic program involved in anatomical structure development|up-regulation of apoptotic program involved in development of an anatomical structure|up-regulation of apoptotic programmed cell death involved in anatomical structure development|up-regulation of apoptotic programmed cell death involved in development of an anatomical structure|up-regulation of commitment to apoptosis involved in anatomical structure development|up-regulation of commitment to apoptosis involved in development of an anatomical structure|up-regulation of induction of apoptosis by p53 involved in anatomical structure development|up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure|up-regulation of induction of apoptosis involved in anatomical structure development|up-regulation of induction of apoptosis involved in development of an anatomical structure|up-regulation of programmed cell death by apoptosis involved in anatomical structure development|up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure|up-regulation of signaling (initiator) caspase activity involved in anatomical structure development|up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|up-regulation of type I programmed cell death involved in anatomical structure development|up-regulation of type I programmed cell death involved in development of an anatomical structure|upregulation of activation of apoptosis involved in anatomical structure development|upregulation of activation of apoptosis involved in development of an anatomical structure|upregulation of apoptosis activator activity involved in anatomical structure development|upregulation of apoptosis activator activity involved in development of an anatomical structure|upregulation of apoptosis involved in anatomical structure development|upregulation of apoptosis involved in development of an anatomical structure|upregulation of apoptosis signaling involved in anatomical structure development|upregulation of apoptosis signaling involved in development of an anatomical structure|upregulation of apoptotic cell death involved in anatomical structure development|upregulation of apoptotic cell death involved in development of an anatomical structure|upregulation of apoptotic process involved in anatomical structure development|upregulation of apoptotic process involved in development|upregulation of apoptotic process involved in development of an anatomical structure|upregulation of apoptotic program involved in anatomical structure development|upregulation of apoptotic program involved in development of an anatomical structure|upregulation of apoptotic programmed cell death involved in anatomical structure development|upregulation of apoptotic programmed cell death involved in development of an anatomical structure|upregulation of commitment to apoptosis involved in anatomical structure development|upregulation of commitment to apoptosis involved in development of an anatomical structure|upregulation of induction of apoptosis by p53 involved in anatomical structure development|upregulation of induction of apoptosis by p53 involved in development of an anatomical structure|upregulation of induction of apoptosis involved in anatomical structure development|upregulation of induction of apoptosis involved in development of an anatomical structure|upregulation of programmed cell death by apoptosis involved in anatomical structure development|upregulation of programmed cell death by apoptosis involved in development of an anatomical structure|upregulation of signaling (initiator) caspase activity involved in anatomical structure development|upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure|upregulation of type I programmed cell death involved in anatomical structure development|upregulation of type I programmed cell death involved in development of an anatomical structure http://purl.obolibrary.org/obo/GO_1904747 GO:1904746 biolink:BiologicalProcess negative regulation of apoptotic process involved in development Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. go.json down regulation of activation of apoptosis involved in anatomical structure development|down regulation of activation of apoptosis involved in development of an anatomical structure|down regulation of apoptosis activator activity involved in anatomical structure development|down regulation of apoptosis activator activity involved in development of an anatomical structure|down regulation of apoptosis involved in anatomical structure development|down regulation of apoptosis involved in development of an anatomical structure|down regulation of apoptosis signaling involved in anatomical structure development|down regulation of apoptosis signaling involved in development of an anatomical structure|down regulation of apoptotic cell death involved in anatomical structure development|down regulation of apoptotic cell death involved in development of an anatomical structure|down regulation of apoptotic process involved in anatomical structure development|down regulation of apoptotic process involved in development|down regulation of apoptotic process involved in development of an anatomical structure|down regulation of apoptotic program involved in anatomical structure development|down regulation of apoptotic program involved in development of an anatomical structure|down regulation of apoptotic programmed cell death involved in anatomical structure development|down regulation of apoptotic programmed cell death involved in development of an anatomical structure|down regulation of commitment to apoptosis involved in anatomical structure development|down regulation of commitment to apoptosis involved in development of an anatomical structure|down regulation of induction of apoptosis by p53 involved in anatomical structure development|down regulation of induction of apoptosis by p53 involved in development of an anatomical structure|down regulation of induction of apoptosis involved in anatomical structure development|down regulation of induction of apoptosis involved in development of an anatomical structure|down regulation of programmed cell death by apoptosis involved in anatomical structure development|down regulation of programmed cell death by apoptosis involved in development of an anatomical structure|down regulation of signaling (initiator) caspase activity involved in anatomical structure development|down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down regulation of type I programmed cell death involved in anatomical structure development|down regulation of type I programmed cell death involved in development of an anatomical structure|down-regulation of activation of apoptosis involved in anatomical structure development|down-regulation of activation of apoptosis involved in development of an anatomical structure|down-regulation of apoptosis activator activity involved in anatomical structure development|down-regulation of apoptosis activator activity involved in development of an anatomical structure|down-regulation of apoptosis involved in anatomical structure development|down-regulation of apoptosis involved in development of an anatomical structure|down-regulation of apoptosis signaling involved in anatomical structure development|down-regulation of apoptosis signaling involved in development of an anatomical structure|down-regulation of apoptotic cell death involved in anatomical structure development|down-regulation of apoptotic cell death involved in development of an anatomical structure|down-regulation of apoptotic process involved in anatomical structure development|down-regulation of apoptotic process involved in development|down-regulation of apoptotic process involved in development of an anatomical structure|down-regulation of apoptotic program involved in anatomical structure development|down-regulation of apoptotic program involved in development of an anatomical structure|down-regulation of apoptotic programmed cell death involved in anatomical structure development|down-regulation of apoptotic programmed cell death involved in development of an anatomical structure|down-regulation of commitment to apoptosis involved in anatomical structure development|down-regulation of commitment to apoptosis involved in development of an anatomical structure|down-regulation of induction of apoptosis by p53 involved in anatomical structure development|down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure|down-regulation of induction of apoptosis involved in anatomical structure development|down-regulation of induction of apoptosis involved in development of an anatomical structure|down-regulation of programmed cell death by apoptosis involved in anatomical structure development|down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure|down-regulation of signaling (initiator) caspase activity involved in anatomical structure development|down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of type I programmed cell death involved in anatomical structure development|down-regulation of type I programmed cell death involved in development of an anatomical structure|downregulation of activation of apoptosis involved in anatomical structure development|downregulation of activation of apoptosis involved in development of an anatomical structure|downregulation of apoptosis activator activity involved in anatomical structure development|downregulation of apoptosis activator activity involved in development of an anatomical structure|downregulation of apoptosis involved in anatomical structure development|downregulation of apoptosis involved in development of an anatomical structure|downregulation of apoptosis signaling involved in anatomical structure development|downregulation of apoptosis signaling involved in development of an anatomical structure|downregulation of apoptotic cell death involved in anatomical structure development|downregulation of apoptotic cell death involved in development of an anatomical structure|downregulation of apoptotic process involved in anatomical structure development|downregulation of apoptotic process involved in development|downregulation of apoptotic process involved in development of an anatomical structure|downregulation of apoptotic program involved in anatomical structure development|downregulation of apoptotic program involved in development of an anatomical structure|downregulation of apoptotic programmed cell death involved in anatomical structure development|downregulation of apoptotic programmed cell death involved in development of an anatomical structure|downregulation of commitment to apoptosis involved in anatomical structure development|downregulation of commitment to apoptosis involved in development of an anatomical structure|downregulation of induction of apoptosis by p53 involved in anatomical structure development|downregulation of induction of apoptosis by p53 involved in development of an anatomical structure|downregulation of induction of apoptosis involved in anatomical structure development|downregulation of induction of apoptosis involved in development of an anatomical structure|downregulation of programmed cell death by apoptosis involved in anatomical structure development|downregulation of programmed cell death by apoptosis involved in development of an anatomical structure|downregulation of signaling (initiator) caspase activity involved in anatomical structure development|downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure|downregulation of type I programmed cell death involved in anatomical structure development|downregulation of type I programmed cell death involved in development of an anatomical structure|inhibition of activation of apoptosis involved in anatomical structure development|inhibition of activation of apoptosis involved in development of an anatomical structure|inhibition of apoptosis activator activity involved in anatomical structure development|inhibition of apoptosis activator activity involved in development of an anatomical structure|inhibition of apoptosis involved in anatomical structure development|inhibition of apoptosis involved in development of an anatomical structure|inhibition of apoptosis signaling involved in anatomical structure development|inhibition of apoptosis signaling involved in development of an anatomical structure|inhibition of apoptotic cell death involved in anatomical structure development|inhibition of apoptotic cell death involved in development of an anatomical structure|inhibition of apoptotic process involved in anatomical structure development|inhibition of apoptotic process involved in development|inhibition of apoptotic process involved in development of an anatomical structure|inhibition of apoptotic program involved in anatomical structure development|inhibition of apoptotic program involved in development of an anatomical structure|inhibition of apoptotic programmed cell death involved in anatomical structure development|inhibition of apoptotic programmed cell death involved in development of an anatomical structure|inhibition of commitment to apoptosis involved in anatomical structure development|inhibition of commitment to apoptosis involved in development of an anatomical structure|inhibition of induction of apoptosis by p53 involved in anatomical structure development|inhibition of induction of apoptosis by p53 involved in development of an anatomical structure|inhibition of induction of apoptosis involved in anatomical structure development|inhibition of induction of apoptosis involved in development of an anatomical structure|inhibition of programmed cell death by apoptosis involved in anatomical structure development|inhibition of programmed cell death by apoptosis involved in development of an anatomical structure|inhibition of signaling (initiator) caspase activity involved in anatomical structure development|inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure|inhibition of type I programmed cell death involved in anatomical structure development|inhibition of type I programmed cell death involved in development of an anatomical structure|negative regulation of activation of apoptosis involved in anatomical structure development|negative regulation of activation of apoptosis involved in development of an anatomical structure|negative regulation of apoptosis activator activity involved in anatomical structure development|negative regulation of apoptosis activator activity involved in development of an anatomical structure|negative regulation of apoptosis involved in anatomical structure development|negative regulation of apoptosis involved in development of an anatomical structure|negative regulation of apoptosis signaling involved in anatomical structure development|negative regulation of apoptosis signaling involved in development of an anatomical structure|negative regulation of apoptotic cell death involved in anatomical structure development|negative regulation of apoptotic cell death involved in development of an anatomical structure|negative regulation of apoptotic process involved in anatomical structure development|negative regulation of apoptotic process involved in development of an anatomical structure|negative regulation of apoptotic program involved in anatomical structure development|negative regulation of apoptotic program involved in development of an anatomical structure|negative regulation of apoptotic programmed cell death involved in anatomical structure development|negative regulation of apoptotic programmed cell death involved in development of an anatomical structure|negative regulation of commitment to apoptosis involved in anatomical structure development|negative regulation of commitment to apoptosis involved in development of an anatomical structure|negative regulation of induction of apoptosis by p53 involved in anatomical structure development|negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure|negative regulation of induction of apoptosis involved in anatomical structure development|negative regulation of induction of apoptosis involved in development of an anatomical structure|negative regulation of programmed cell death by apoptosis involved in anatomical structure development|negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure|negative regulation of signaling (initiator) caspase activity involved in anatomical structure development|negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|negative regulation of type I programmed cell death involved in anatomical structure development|negative regulation of type I programmed cell death involved in development of an anatomical structure http://purl.obolibrary.org/obo/GO_1904746 GO:1904745 biolink:BiologicalProcess Atg1/ULK1 kinase complex assembly The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex. go.json ATG1 kinase complex assembly|ATG1 kinase complex formation|ATG1-ATG13 complex assembly|ATG1-ATG13 complex formation|ATG1/ULK1 kinase complex formation|ATG1/ULK1 signaling complex assembly|ATG1/ULK1 signaling complex formation|Atg1p signalling complex assembly|Atg1p signalling complex formation|ULK1 signaling complex assembly|ULK1 signaling complex formation|ULK1-ATG13-FIP200 complex assembly|ULK1-ATG13-FIP200 complex formation|ULK1-ATG13-RB1CC1 complex assembly|ULK1-ATG13-RB1CC1 complex formation http://purl.obolibrary.org/obo/GO_1904745 GO:1904744 biolink:BiologicalProcess positive regulation of telomeric DNA binding Any process that activates or increases the frequency, rate or extent of telomeric DNA binding. go.json activation of telomere binding|activation of telomeric DNA binding|activation of telomeric repeat binding|positive regulation of telomere binding|positive regulation of telomeric repeat binding|up regulation of telomere binding|up regulation of telomeric DNA binding|up regulation of telomeric repeat binding|up-regulation of telomere binding|up-regulation of telomeric DNA binding|up-regulation of telomeric repeat binding|upregulation of telomere binding|upregulation of telomeric DNA binding|upregulation of telomeric repeat binding http://purl.obolibrary.org/obo/GO_1904744 gocheck_do_not_annotate GO:1904743 biolink:BiologicalProcess negative regulation of telomeric DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding. go.json down regulation of telomere binding|down regulation of telomeric DNA binding|down regulation of telomeric repeat binding|down-regulation of telomere binding|down-regulation of telomeric DNA binding|down-regulation of telomeric repeat binding|downregulation of telomere binding|downregulation of telomeric DNA binding|downregulation of telomeric repeat binding|inhibition of telomere binding|inhibition of telomeric DNA binding|inhibition of telomeric repeat binding|negative regulation of telomere binding|negative regulation of telomeric repeat binding http://purl.obolibrary.org/obo/GO_1904743 gocheck_do_not_annotate GO:1904742 biolink:BiologicalProcess regulation of telomeric DNA binding Any process that modulates the frequency, rate or extent of telomeric DNA binding. go.json regulation of telomere binding|regulation of telomeric repeat binding http://purl.obolibrary.org/obo/GO_1904742 gocheck_do_not_annotate GO:1904741 biolink:BiologicalProcess obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation. go.json positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of global transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of global transcription from Pol II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from Pol II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter, global|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of global transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of global transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of global transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of global transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1904741 GO:1904740 biolink:BiologicalProcess obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter OBSOLETE. A transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation. go.json positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by RNA polymerase II transcription factor activity|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by gene-specific transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by general transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by specific transcription from RNA polymerase II promoter|positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from Pol II promoter True http://purl.obolibrary.org/obo/GO_1904740 GO:1904750 biolink:BiologicalProcess negative regulation of protein localization to nucleolus Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. go.json down regulation of protein localisation in nucleolus|down regulation of protein localisation to nucleolus|down regulation of protein localization in nucleolus|down regulation of protein localization to nucleolus|down-regulation of protein localisation in nucleolus|down-regulation of protein localisation to nucleolus|down-regulation of protein localization in nucleolus|down-regulation of protein localization to nucleolus|downregulation of protein localisation in nucleolus|downregulation of protein localisation to nucleolus|downregulation of protein localization in nucleolus|downregulation of protein localization to nucleolus|inhibition of protein localisation in nucleolus|inhibition of protein localisation to nucleolus|inhibition of protein localization in nucleolus|inhibition of protein localization to nucleolus|negative regulation of protein localisation in nucleolus|negative regulation of protein localisation to nucleolus|negative regulation of protein localization in nucleolus http://purl.obolibrary.org/obo/GO_1904750 GO:1904759 biolink:BiologicalProcess protein localization to equatorial microtubule organizing center A process in which a protein is transported to, or maintained in, a location within an equatorial microtubule organizing center. go.json protein localisation in equatorial microtubule organizing center|protein localisation to equatorial microtubule organizing center|protein localization in equatorial microtubule organizing center|protein localization to eMTOC http://purl.obolibrary.org/obo/GO_1904759 GO:1904758 biolink:BiologicalProcess protein localization to new growing cell tip A process in which a protein is transported to, or maintained in, a location within a new growing cell tip. go.json protein localisation in new growing cell tip|protein localisation to new growing cell tip|protein localization in new growing cell tip|protein localization to new cell tip after activation of bipolar cell growth|protein localization to new growing cell end|protein localization to post-NETO new cell end|protein localization to post-NETO new cell tip|protein localization to post-new end take-off new cell tip http://purl.obolibrary.org/obo/GO_1904758 GO:1904757 biolink:BiologicalProcess positive regulation of gut granule assembly Any process that activates or increases the frequency, rate or extent of gut granule assembly. go.json activation of gut granule assembly|activation of gut granule biogenesis|activation of gut granule formation|positive regulation of gut granule biogenesis|positive regulation of gut granule formation|up regulation of gut granule assembly|up regulation of gut granule biogenesis|up regulation of gut granule formation|up-regulation of gut granule assembly|up-regulation of gut granule biogenesis|up-regulation of gut granule formation|upregulation of gut granule assembly|upregulation of gut granule biogenesis|upregulation of gut granule formation http://purl.obolibrary.org/obo/GO_1904757 GO:1904756 biolink:BiologicalProcess negative regulation of gut granule assembly Any process that stops, prevents or reduces the frequency, rate or extent of gut granule assembly. go.json down regulation of gut granule assembly|down regulation of gut granule biogenesis|down regulation of gut granule formation|down-regulation of gut granule assembly|down-regulation of gut granule biogenesis|down-regulation of gut granule formation|downregulation of gut granule assembly|downregulation of gut granule biogenesis|downregulation of gut granule formation|inhibition of gut granule assembly|inhibition of gut granule biogenesis|inhibition of gut granule formation|negative regulation of gut granule biogenesis|negative regulation of gut granule formation http://purl.obolibrary.org/obo/GO_1904756 GO:1904755 biolink:BiologicalProcess regulation of gut granule assembly Any process that modulates the frequency, rate or extent of gut granule assembly. go.json regulation of gut granule biogenesis|regulation of gut granule formation http://purl.obolibrary.org/obo/GO_1904755 GO:1904754 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle cell migration Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. go.json activation of vascular associated smooth muscle cell migration|activation of vascular smooth muscle cell migration|positive regulation of vascular smooth muscle cell migration|up regulation of vascular associated smooth muscle cell migration|up regulation of vascular smooth muscle cell migration|up-regulation of vascular associated smooth muscle cell migration|up-regulation of vascular smooth muscle cell migration|upregulation of vascular associated smooth muscle cell migration|upregulation of vascular smooth muscle cell migration http://purl.obolibrary.org/obo/GO_1904754 GO:1904753 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle cell migration Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. go.json down regulation of vascular associated smooth muscle cell migration|down regulation of vascular smooth muscle cell migration|down-regulation of vascular associated smooth muscle cell migration|down-regulation of vascular smooth muscle cell migration|downregulation of vascular associated smooth muscle cell migration|downregulation of vascular smooth muscle cell migration|inhibition of vascular associated smooth muscle cell migration|inhibition of vascular smooth muscle cell migration|negative regulation of vascular smooth muscle cell migration http://purl.obolibrary.org/obo/GO_1904753 GO:1904752 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell migration Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. go.json regulation of vascular smooth muscle cell migration http://purl.obolibrary.org/obo/GO_1904752 GO:1904751 biolink:BiologicalProcess positive regulation of protein localization to nucleolus Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. go.json activation of protein localisation in nucleolus|activation of protein localisation to nucleolus|activation of protein localization in nucleolus|activation of protein localization to nucleolus|positive regulation of protein localisation in nucleolus|positive regulation of protein localisation to nucleolus|positive regulation of protein localization in nucleolus|up regulation of protein localisation in nucleolus|up regulation of protein localisation to nucleolus|up regulation of protein localization in nucleolus|up regulation of protein localization to nucleolus|up-regulation of protein localisation in nucleolus|up-regulation of protein localisation to nucleolus|up-regulation of protein localization in nucleolus|up-regulation of protein localization to nucleolus|upregulation of protein localisation in nucleolus|upregulation of protein localisation to nucleolus|upregulation of protein localization in nucleolus|upregulation of protein localization to nucleolus http://purl.obolibrary.org/obo/GO_1904751 GO:1904761 biolink:BiologicalProcess negative regulation of myofibroblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation. go.json down regulation of myofibroblast cell differentiation|down regulation of myofibroblast differentiation|down-regulation of myofibroblast cell differentiation|down-regulation of myofibroblast differentiation|downregulation of myofibroblast cell differentiation|downregulation of myofibroblast differentiation|inhibition of myofibroblast cell differentiation|inhibition of myofibroblast differentiation|negative regulation of myofibroblast cell differentiation http://purl.obolibrary.org/obo/GO_1904761 GO:1904760 biolink:BiologicalProcess regulation of myofibroblast differentiation Any process that modulates the frequency, rate or extent of myofibroblast differentiation. go.json regulation of myofibroblast cell differentiation http://purl.obolibrary.org/obo/GO_1904760 GO:1904769 biolink:MolecularActivity isopentadecanoic acid binding Binding to isopentadecanoic acid. go.json 13-methylmyristic acid binding http://purl.obolibrary.org/obo/GO_1904769 GO:1904768 biolink:MolecularActivity all-trans-retinol binding Binding to all-trans-retinol. go.json http://purl.obolibrary.org/obo/GO_1904768 GO:1904767 biolink:MolecularActivity octanoic acid binding Binding to octanoic acid. go.json caprylic acid binding http://purl.obolibrary.org/obo/GO_1904767 GO:1904766 biolink:BiologicalProcess obsolete negative regulation of macroautophagy by TORC1 signaling OBSOLETE. A TORC1 signaling that results in negative regulation of macroautophagy. go.json negative regulation of autophagy in response to cellular starvation by TORC1 signal transduction|negative regulation of autophagy in response to cellular starvation by TORC1 signaling|negative regulation of macroautophagy by TORC1 signal transduction|negative regulation of non-specific autophagy by TORC1 signal transduction|negative regulation of non-specific autophagy by TORC1 signaling|negative regulation of starvation-induced autophagy by TORC1 signal transduction|negative regulation of starvation-induced autophagy by TORC1 signaling True http://purl.obolibrary.org/obo/GO_1904766 GO:1904765 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter in response to maltose OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus. go.json activation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|activation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|positive regulation of global transcription from Pol II promoter involved in cellular response to maltose stimulus|positive regulation of transcription from Pol II promoter involved in cellular response to maltose stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|positive regulation of transcription from RNA polymerase II promoter, global involved in cellular response to maltose stimulus|stimulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|stimulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|up regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|up regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|upregulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus|upregulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus True http://purl.obolibrary.org/obo/GO_1904765 GO:1904764 biolink:BiologicalProcess chaperone-mediated autophagy translocation complex disassembly The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components. go.json CMA receptor complex disassembly|CMA translocation complex disassembly|chaperone-mediated autophagy receptor complex disassembly http://purl.obolibrary.org/obo/GO_1904764 GO:1904763 biolink:BiologicalProcess chaperone-mediated autophagy translocation complex assembly The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex. go.json CMA receptor complex assembly|CMA receptor complex formation|CMA translocation complex assembly|CMA translocation complex formation|chaperone-mediated autophagy receptor complex assembly|chaperone-mediated autophagy receptor complex formation|chaperone-mediated autophagy translocation complex formation http://purl.obolibrary.org/obo/GO_1904763 GO:1904762 biolink:BiologicalProcess positive regulation of myofibroblast differentiation Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation. go.json activation of myofibroblast cell differentiation|activation of myofibroblast differentiation|positive regulation of myofibroblast cell differentiation|up regulation of myofibroblast cell differentiation|up regulation of myofibroblast differentiation|up-regulation of myofibroblast cell differentiation|up-regulation of myofibroblast differentiation|upregulation of myofibroblast cell differentiation|upregulation of myofibroblast differentiation http://purl.obolibrary.org/obo/GO_1904762 GO:1904772 biolink:BiologicalProcess response to tetrachloromethane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus. go.json response to CCL4|response to carbon tetrachloride http://purl.obolibrary.org/obo/GO_1904772 GO:1904771 biolink:BiologicalProcess obsolete cellular response to doxorubicin OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904771 GO:1904770 biolink:BiologicalProcess intramembranous bone morphogenesis The developmental process by which an intramembranous bone is generated and organized. go.json intramembranous bones morphogenesis|membrane bone morphogenesis http://purl.obolibrary.org/obo/GO_1904770 GO:1904779 biolink:BiologicalProcess regulation of protein localization to centrosome Any process that modulates the frequency, rate or extent of protein localization to centrosome. go.json regulation of protein localisation to centrosome http://purl.obolibrary.org/obo/GO_1904779 GO:1904778 biolink:BiologicalProcess positive regulation of protein localization to cell cortex Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. go.json activation of protein localisation to cell cortex|activation of protein localization to cell cortex|positive regulation of protein localisation to cell cortex|up regulation of protein localisation to cell cortex|up regulation of protein localization to cell cortex|up-regulation of protein localisation to cell cortex|up-regulation of protein localization to cell cortex|upregulation of protein localisation to cell cortex|upregulation of protein localization to cell cortex http://purl.obolibrary.org/obo/GO_1904778 GO:1904777 biolink:BiologicalProcess negative regulation of protein localization to cell cortex Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. go.json down regulation of protein localisation to cell cortex|down regulation of protein localization to cell cortex|down-regulation of protein localisation to cell cortex|down-regulation of protein localization to cell cortex|downregulation of protein localisation to cell cortex|downregulation of protein localization to cell cortex|inhibition of protein localisation to cell cortex|inhibition of protein localization to cell cortex|negative regulation of protein localisation to cell cortex http://purl.obolibrary.org/obo/GO_1904777 GO:1904776 biolink:BiologicalProcess regulation of protein localization to cell cortex Any process that modulates the frequency, rate or extent of protein localization to cell cortex. go.json regulation of protein localisation to cell cortex http://purl.obolibrary.org/obo/GO_1904776 GO:1904775 biolink:BiologicalProcess positive regulation of ubiquinone biosynthetic process Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process. go.json activation of coenzyme Q biosynthesis|activation of coenzyme Q biosynthetic process|activation of coenzyme Q10 biosynthesis|activation of coenzyme Q10 biosynthetic process|activation of coenzyme Q6 biosynthesis|activation of coenzyme Q6 biosynthetic process|activation of coenzyme Q8 biosynthesis|activation of coenzyme Q8 biosynthetic process|activation of coenzyme Q9 biosynthesis|activation of coenzyme Q9 biosynthetic process|activation of ubiquinone anabolism|activation of ubiquinone biosynthesis|activation of ubiquinone biosynthetic process|activation of ubiquinone formation|activation of ubiquinone synthesis|positive regulation of coenzyme Q biosynthesis|positive regulation of coenzyme Q biosynthetic process|positive regulation of coenzyme Q10 biosynthesis|positive regulation of coenzyme Q10 biosynthetic process|positive regulation of coenzyme Q6 biosynthesis|positive regulation of coenzyme Q6 biosynthetic process|positive regulation of coenzyme Q8 biosynthesis|positive regulation of coenzyme Q8 biosynthetic process|positive regulation of coenzyme Q9 biosynthesis|positive regulation of coenzyme Q9 biosynthetic process|positive regulation of ubiquinone anabolism|positive regulation of ubiquinone biosynthesis|positive regulation of ubiquinone formation|positive regulation of ubiquinone synthesis|up regulation of coenzyme Q biosynthesis|up regulation of coenzyme Q biosynthetic process|up regulation of coenzyme Q10 biosynthesis|up regulation of coenzyme Q10 biosynthetic process|up regulation of coenzyme Q6 biosynthesis|up regulation of coenzyme Q6 biosynthetic process|up regulation of coenzyme Q8 biosynthesis|up regulation of coenzyme Q8 biosynthetic process|up regulation of coenzyme Q9 biosynthesis|up regulation of coenzyme Q9 biosynthetic process|up regulation of ubiquinone anabolism|up regulation of ubiquinone biosynthesis|up regulation of ubiquinone biosynthetic process|up regulation of ubiquinone formation|up regulation of ubiquinone synthesis|up-regulation of coenzyme Q biosynthesis|up-regulation of coenzyme Q biosynthetic process|up-regulation of coenzyme Q10 biosynthesis|up-regulation of coenzyme Q10 biosynthetic process|up-regulation of coenzyme Q6 biosynthesis|up-regulation of coenzyme Q6 biosynthetic process|up-regulation of coenzyme Q8 biosynthesis|up-regulation of coenzyme Q8 biosynthetic process|up-regulation of coenzyme Q9 biosynthesis|up-regulation of coenzyme Q9 biosynthetic process|up-regulation of ubiquinone anabolism|up-regulation of ubiquinone biosynthesis|up-regulation of ubiquinone biosynthetic process|up-regulation of ubiquinone formation|up-regulation of ubiquinone synthesis|upregulation of coenzyme Q biosynthesis|upregulation of coenzyme Q biosynthetic process|upregulation of coenzyme Q10 biosynthesis|upregulation of coenzyme Q10 biosynthetic process|upregulation of coenzyme Q6 biosynthesis|upregulation of coenzyme Q6 biosynthetic process|upregulation of coenzyme Q8 biosynthesis|upregulation of coenzyme Q8 biosynthetic process|upregulation of coenzyme Q9 biosynthesis|upregulation of coenzyme Q9 biosynthetic process|upregulation of ubiquinone anabolism|upregulation of ubiquinone biosynthesis|upregulation of ubiquinone biosynthetic process|upregulation of ubiquinone formation|upregulation of ubiquinone synthesis http://purl.obolibrary.org/obo/GO_1904775 GO:1904774 biolink:BiologicalProcess negative regulation of ubiquinone biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ubiquinone biosynthetic process. go.json down regulation of coenzyme Q biosynthesis|down regulation of coenzyme Q biosynthetic process|down regulation of coenzyme Q10 biosynthesis|down regulation of coenzyme Q10 biosynthetic process|down regulation of coenzyme Q6 biosynthesis|down regulation of coenzyme Q6 biosynthetic process|down regulation of coenzyme Q8 biosynthesis|down regulation of coenzyme Q8 biosynthetic process|down regulation of coenzyme Q9 biosynthesis|down regulation of coenzyme Q9 biosynthetic process|down regulation of ubiquinone anabolism|down regulation of ubiquinone biosynthesis|down regulation of ubiquinone biosynthetic process|down regulation of ubiquinone formation|down regulation of ubiquinone synthesis|down-regulation of coenzyme Q biosynthesis|down-regulation of coenzyme Q biosynthetic process|down-regulation of coenzyme Q10 biosynthesis|down-regulation of coenzyme Q10 biosynthetic process|down-regulation of coenzyme Q6 biosynthesis|down-regulation of coenzyme Q6 biosynthetic process|down-regulation of coenzyme Q8 biosynthesis|down-regulation of coenzyme Q8 biosynthetic process|down-regulation of coenzyme Q9 biosynthesis|down-regulation of coenzyme Q9 biosynthetic process|down-regulation of ubiquinone anabolism|down-regulation of ubiquinone biosynthesis|down-regulation of ubiquinone biosynthetic process|down-regulation of ubiquinone formation|down-regulation of ubiquinone synthesis|downregulation of coenzyme Q biosynthesis|downregulation of coenzyme Q biosynthetic process|downregulation of coenzyme Q10 biosynthesis|downregulation of coenzyme Q10 biosynthetic process|downregulation of coenzyme Q6 biosynthesis|downregulation of coenzyme Q6 biosynthetic process|downregulation of coenzyme Q8 biosynthesis|downregulation of coenzyme Q8 biosynthetic process|downregulation of coenzyme Q9 biosynthesis|downregulation of coenzyme Q9 biosynthetic process|downregulation of ubiquinone anabolism|downregulation of ubiquinone biosynthesis|downregulation of ubiquinone biosynthetic process|downregulation of ubiquinone formation|downregulation of ubiquinone synthesis|inhibition of coenzyme Q biosynthesis|inhibition of coenzyme Q biosynthetic process|inhibition of coenzyme Q10 biosynthesis|inhibition of coenzyme Q10 biosynthetic process|inhibition of coenzyme Q6 biosynthesis|inhibition of coenzyme Q6 biosynthetic process|inhibition of coenzyme Q8 biosynthesis|inhibition of coenzyme Q8 biosynthetic process|inhibition of coenzyme Q9 biosynthesis|inhibition of coenzyme Q9 biosynthetic process|inhibition of ubiquinone anabolism|inhibition of ubiquinone biosynthesis|inhibition of ubiquinone biosynthetic process|inhibition of ubiquinone formation|inhibition of ubiquinone synthesis|negative regulation of coenzyme Q biosynthesis|negative regulation of coenzyme Q biosynthetic process|negative regulation of coenzyme Q10 biosynthesis|negative regulation of coenzyme Q10 biosynthetic process|negative regulation of coenzyme Q6 biosynthesis|negative regulation of coenzyme Q6 biosynthetic process|negative regulation of coenzyme Q8 biosynthesis|negative regulation of coenzyme Q8 biosynthetic process|negative regulation of coenzyme Q9 biosynthesis|negative regulation of coenzyme Q9 biosynthetic process|negative regulation of ubiquinone anabolism|negative regulation of ubiquinone biosynthesis|negative regulation of ubiquinone formation|negative regulation of ubiquinone synthesis http://purl.obolibrary.org/obo/GO_1904774 GO:1904773 biolink:BiologicalProcess obsolete cellular response to tetrachloromethane OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus. go.json cellular response to CCL4|cellular response to carbon tetrachloride True http://purl.obolibrary.org/obo/GO_1904773 GO:1904783 biolink:BiologicalProcess positive regulation of NMDA glutamate receptor activity Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity. go.json activation of N-methyl-D-aspartate selective glutamate receptor activity|activation of NMDA glutamate receptor activity|activation of NMDA receptor|positive regulation of N-methyl-D-aspartate selective glutamate receptor activity|positive regulation of NMDA receptor|up regulation of N-methyl-D-aspartate selective glutamate receptor activity|up regulation of NMDA glutamate receptor activity|up regulation of NMDA receptor|up-regulation of N-methyl-D-aspartate selective glutamate receptor activity|up-regulation of NMDA glutamate receptor activity|up-regulation of NMDA receptor|upregulation of N-methyl-D-aspartate selective glutamate receptor activity|upregulation of NMDA glutamate receptor activity|upregulation of NMDA receptor http://purl.obolibrary.org/obo/GO_1904783 gocheck_do_not_annotate GO:1904782 biolink:BiologicalProcess negative regulation of NMDA glutamate receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity. go.json down regulation of N-methyl-D-aspartate selective glutamate receptor activity|down regulation of NMDA glutamate receptor activity|down regulation of NMDA receptor|down-regulation of N-methyl-D-aspartate selective glutamate receptor activity|down-regulation of NMDA glutamate receptor activity|down-regulation of NMDA receptor|downregulation of N-methyl-D-aspartate selective glutamate receptor activity|downregulation of NMDA glutamate receptor activity|downregulation of NMDA receptor|inhibition of N-methyl-D-aspartate selective glutamate receptor activity|inhibition of NMDA glutamate receptor activity|inhibition of NMDA receptor|negative regulation of N-methyl-D-aspartate selective glutamate receptor activity|negative regulation of NMDA receptor http://purl.obolibrary.org/obo/GO_1904782 gocheck_do_not_annotate GO:1904781 biolink:BiologicalProcess positive regulation of protein localization to centrosome Any process that activates or increases the frequency, rate or extent of protein localization to centrosome. go.json activation of protein localisation to centrosome|activation of protein localization to centrosome|positive regulation of protein localisation to centrosome|up regulation of protein localisation to centrosome|up regulation of protein localization to centrosome|up-regulation of protein localisation to centrosome|up-regulation of protein localization to centrosome|upregulation of protein localisation to centrosome|upregulation of protein localization to centrosome http://purl.obolibrary.org/obo/GO_1904781 GO:1904780 biolink:BiologicalProcess negative regulation of protein localization to centrosome Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome. go.json down regulation of protein localisation to centrosome|down regulation of protein localization to centrosome|down-regulation of protein localisation to centrosome|down-regulation of protein localization to centrosome|downregulation of protein localisation to centrosome|downregulation of protein localization to centrosome|inhibition of protein localisation to centrosome|inhibition of protein localization to centrosome|negative regulation of protein localisation to centrosome http://purl.obolibrary.org/obo/GO_1904780 GO:1904789 biolink:BiologicalProcess obsolete regulation of mitotic actomyosin contractile ring maintenance OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring maintenance. go.json regulation of contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle|regulation of cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle True http://purl.obolibrary.org/obo/GO_1904789 GO:1904788 biolink:BiologicalProcess obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion. go.json positive regulation of induction of conjugation with cellular fusion by global transcription regulation from Pol II promoter|positive regulation of induction of conjugation with cellular fusion by regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of induction of conjugation with cellular fusion by regulation of global transcription from Pol II promoter|positive regulation of induction of conjugation with cellular fusion by regulation of transcription from Pol II promoter|positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter, global True http://purl.obolibrary.org/obo/GO_1904788 GO:1904787 biolink:BiologicalProcess positive regulation of asymmetric protein localization involved in cell fate determination Any process that activates or increases the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. go.json activation of asymmetric protein localisation involved in cell fate determination|activation of asymmetric protein localization involved in cell fate commitment|activation of asymmetric protein localization involved in cell fate determination|activation of asymmetric protein localization resulting in cell fate commitment|activation of cell fate commitment, asymmetric protein localization|positive regulation of asymmetric protein localisation involved in cell fate determination|positive regulation of asymmetric protein localization involved in cell fate commitment|positive regulation of asymmetric protein localization resulting in cell fate commitment|positive regulation of cell fate commitment, asymmetric protein localization|up regulation of asymmetric protein localisation involved in cell fate determination|up regulation of asymmetric protein localization involved in cell fate commitment|up regulation of asymmetric protein localization involved in cell fate determination|up regulation of asymmetric protein localization resulting in cell fate commitment|up regulation of cell fate commitment, asymmetric protein localization|up-regulation of asymmetric protein localisation involved in cell fate determination|up-regulation of asymmetric protein localization involved in cell fate commitment|up-regulation of asymmetric protein localization involved in cell fate determination|up-regulation of asymmetric protein localization resulting in cell fate commitment|up-regulation of cell fate commitment, asymmetric protein localization|upregulation of asymmetric protein localisation involved in cell fate determination|upregulation of asymmetric protein localization involved in cell fate commitment|upregulation of asymmetric protein localization involved in cell fate determination|upregulation of asymmetric protein localization resulting in cell fate commitment|upregulation of cell fate commitment, asymmetric protein localization http://purl.obolibrary.org/obo/GO_1904787 GO:1904786 biolink:BiologicalProcess negative regulation of asymmetric protein localization involved in cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. go.json down regulation of asymmetric protein localisation involved in cell fate determination|down regulation of asymmetric protein localization involved in cell fate commitment|down regulation of asymmetric protein localization involved in cell fate determination|down regulation of asymmetric protein localization resulting in cell fate commitment|down regulation of cell fate commitment, asymmetric protein localization|down-regulation of asymmetric protein localisation involved in cell fate determination|down-regulation of asymmetric protein localization involved in cell fate commitment|down-regulation of asymmetric protein localization involved in cell fate determination|down-regulation of asymmetric protein localization resulting in cell fate commitment|down-regulation of cell fate commitment, asymmetric protein localization|downregulation of asymmetric protein localisation involved in cell fate determination|downregulation of asymmetric protein localization involved in cell fate commitment|downregulation of asymmetric protein localization involved in cell fate determination|downregulation of asymmetric protein localization resulting in cell fate commitment|downregulation of cell fate commitment, asymmetric protein localization|inhibition of asymmetric protein localisation involved in cell fate determination|inhibition of asymmetric protein localization involved in cell fate commitment|inhibition of asymmetric protein localization involved in cell fate determination|inhibition of asymmetric protein localization resulting in cell fate commitment|inhibition of cell fate commitment, asymmetric protein localization|negative regulation of asymmetric protein localisation involved in cell fate determination|negative regulation of asymmetric protein localization involved in cell fate commitment|negative regulation of asymmetric protein localization resulting in cell fate commitment|negative regulation of cell fate commitment, asymmetric protein localization http://purl.obolibrary.org/obo/GO_1904786 GO:1904785 biolink:BiologicalProcess regulation of asymmetric protein localization involved in cell fate determination Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. go.json regulation of asymmetric protein localisation involved in cell fate determination|regulation of asymmetric protein localization involved in cell fate commitment|regulation of asymmetric protein localization resulting in cell fate commitment|regulation of cell fate commitment, asymmetric protein localization http://purl.obolibrary.org/obo/GO_1904785 GO:1904784 biolink:BiologicalProcess NLRP1 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex. go.json NALP1 inflammasome complex assembly|NALP1 inflammasome complex formation|NLRP1 inflammasome complex formation http://purl.obolibrary.org/obo/GO_1904784 GO:1904794 biolink:BiologicalProcess negative regulation of euchromatin binding Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding. go.json down regulation of euchromatin binding|down-regulation of euchromatin binding|downregulation of euchromatin binding|inhibition of euchromatin binding http://purl.obolibrary.org/obo/GO_1904794 gocheck_do_not_annotate GO:1904793 biolink:BiologicalProcess regulation of euchromatin binding Any process that modulates the frequency, rate or extent of euchromatin binding. go.json http://purl.obolibrary.org/obo/GO_1904793 gocheck_do_not_annotate GO:1904792 biolink:BiologicalProcess positive regulation of shelterin complex assembly Any process that activates or increases the frequency, rate or extent of shelterin complex assembly. go.json activation of Pot1 complex assembly|activation of Pot1-Tpz1 complex assembly|activation of shelterin complex formation|activation of telosome assembly|positive regulation of Pot1 complex assembly|positive regulation of Pot1-Tpz1 complex assembly|positive regulation of shelterin complex formation|positive regulation of telosome assembly|up regulation of Pot1 complex assembly|up regulation of Pot1-Tpz1 complex assembly|up regulation of shelterin complex formation|up regulation of telosome assembly|up-regulation of Pot1 complex assembly|up-regulation of Pot1-Tpz1 complex assembly|up-regulation of shelterin complex formation|up-regulation of telosome assembly|upregulation of Pot1 complex assembly|upregulation of Pot1-Tpz1 complex assembly|upregulation of shelterin complex formation|upregulation of telosome assembly http://purl.obolibrary.org/obo/GO_1904792 GO:1904791 biolink:BiologicalProcess negative regulation of shelterin complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of shelterin complex assembly. go.json down regulation of Pot1 complex assembly|down regulation of Pot1-Tpz1 complex assembly|down regulation of shelterin complex formation|down regulation of telosome assembly|down-regulation of Pot1 complex assembly|down-regulation of Pot1-Tpz1 complex assembly|down-regulation of shelterin complex formation|down-regulation of telosome assembly|downregulation of Pot1 complex assembly|downregulation of Pot1-Tpz1 complex assembly|downregulation of shelterin complex formation|downregulation of telosome assembly|inhibition of Pot1 complex assembly|inhibition of Pot1-Tpz1 complex assembly|inhibition of shelterin complex formation|inhibition of telosome assembly|negative regulation of Pot1 complex assembly|negative regulation of Pot1-Tpz1 complex assembly|negative regulation of shelterin complex formation|negative regulation of telosome assembly http://purl.obolibrary.org/obo/GO_1904791 GO:1904790 biolink:BiologicalProcess regulation of shelterin complex assembly Any process that modulates the frequency, rate or extent of shelterin complex assembly. go.json regulation of Pot1 complex assembly|regulation of Pot1-Tpz1 complex assembly|regulation of shelterin complex formation|regulation of telosome assembly http://purl.obolibrary.org/obo/GO_1904790 GO:1904709 biolink:BiologicalProcess negative regulation of granulosa cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process. go.json down regulation of granulosa cell apoptosis|down regulation of granulosa cell apoptotic process|down regulation of granulosa cell of ovary apoptosis|down regulation of granulosa cell of ovary apoptotic process|down-regulation of granulosa cell apoptosis|down-regulation of granulosa cell apoptotic process|down-regulation of granulosa cell of ovary apoptosis|down-regulation of granulosa cell of ovary apoptotic process|downregulation of granulosa cell apoptosis|downregulation of granulosa cell apoptotic process|downregulation of granulosa cell of ovary apoptosis|downregulation of granulosa cell of ovary apoptotic process|inhibition of granulosa cell apoptosis|inhibition of granulosa cell apoptotic process|inhibition of granulosa cell of ovary apoptosis|inhibition of granulosa cell of ovary apoptotic process|negative regulation of granulosa cell apoptosis|negative regulation of granulosa cell of ovary apoptosis|negative regulation of granulosa cell of ovary apoptotic process http://purl.obolibrary.org/obo/GO_1904709 GO:1904708 biolink:BiologicalProcess regulation of granulosa cell apoptotic process Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process. go.json regulation of granulosa cell apoptosis|regulation of granulosa cell of ovary apoptosis|regulation of granulosa cell of ovary apoptotic process http://purl.obolibrary.org/obo/GO_1904708 GO:1904707 biolink:BiologicalProcess positive regulation of vascular associated smooth muscle cell proliferation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. go.json activation of VSMC proliferation|activation of vascular smooth muscle cell proliferation|positive regulation of VSMC proliferation|positive regulation of vascular smooth muscle cell proliferation|up regulation of VSMC proliferation|up regulation of vascular smooth muscle cell proliferation|up-regulation of VSMC proliferation|up-regulation of vascular smooth muscle cell proliferation|upregulation of VSMC proliferation|upregulation of vascular smooth muscle cell proliferation http://purl.obolibrary.org/obo/GO_1904707 GO:1904706 biolink:BiologicalProcess negative regulation of vascular associated smooth muscle cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. go.json down regulation of VSMC proliferation|down regulation of vascular smooth muscle cell proliferation|down-regulation of VSMC proliferation|down-regulation of vascular smooth muscle cell proliferation|downregulation of VSMC proliferation|downregulation of vascular smooth muscle cell proliferation|inhibition of VSMC proliferation|inhibition of vascular smooth muscle cell proliferation|negative regulation of VSMC proliferation|negative regulation of vascular smooth muscle cell proliferation http://purl.obolibrary.org/obo/GO_1904706 GO:1904705 biolink:BiologicalProcess regulation of vascular associated smooth muscle cell proliferation Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. go.json regulation of VSMC proliferation|regulation of vascular smooth muscle cell proliferation http://purl.obolibrary.org/obo/GO_1904705 GO:1904704 biolink:BiologicalProcess positive regulation of protein localization to adherens junction Any process that activates or increases the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json activation of protein localisation in cell-cell adherens junction|activation of protein localisation to cell-cell adherens junction|activation of protein localization in cell-cell adherens junction|activation of protein localization to cell-cell adherens junction|positive regulation of protein localisation in cell-cell adherens junction|positive regulation of protein localisation to cell-cell adherens junction|positive regulation of protein localization in cell-cell adherens junction|up regulation of protein localisation in cell-cell adherens junction|up regulation of protein localisation to cell-cell adherens junction|up regulation of protein localization in cell-cell adherens junction|up regulation of protein localization to cell-cell adherens junction|up-regulation of protein localisation in cell-cell adherens junction|up-regulation of protein localisation to cell-cell adherens junction|up-regulation of protein localization in cell-cell adherens junction|up-regulation of protein localization to cell-cell adherens junction|upregulation of protein localisation in cell-cell adherens junction|upregulation of protein localisation to cell-cell adherens junction|upregulation of protein localization in cell-cell adherens junction|upregulation of protein localization to cell-cell adherens junction http://purl.obolibrary.org/obo/GO_1904704 GO:1904703 biolink:BiologicalProcess negative regulation of protein localization to adherens junction Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json down regulation of protein localisation in cell-cell adherens junction|down regulation of protein localisation to cell-cell adherens junction|down regulation of protein localization in cell-cell adherens junction|down regulation of protein localization to cell-cell adherens junction|down-regulation of protein localisation in cell-cell adherens junction|down-regulation of protein localisation to cell-cell adherens junction|down-regulation of protein localization in cell-cell adherens junction|down-regulation of protein localization to cell-cell adherens junction|downregulation of protein localisation in cell-cell adherens junction|downregulation of protein localisation to cell-cell adherens junction|downregulation of protein localization in cell-cell adherens junction|downregulation of protein localization to cell-cell adherens junction|inhibition of protein localisation in cell-cell adherens junction|inhibition of protein localisation to cell-cell adherens junction|inhibition of protein localization in cell-cell adherens junction|inhibition of protein localization to cell-cell adherens junction|negative regulation of protein localisation in cell-cell adherens junction|negative regulation of protein localisation to cell-cell adherens junction|negative regulation of protein localization in cell-cell adherens junction http://purl.obolibrary.org/obo/GO_1904703 GO:1904702 biolink:BiologicalProcess regulation of protein localization to adherens junction Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. go.json regulation of protein localisation in cell-cell adherens junction|regulation of protein localisation to cell-cell adherens junction|regulation of protein localization in cell-cell adherens junction http://purl.obolibrary.org/obo/GO_1904702 GO:1904701 biolink:BiologicalProcess Wnt-Frizzled-LRP5/6 complex assembly The aggregation, arrangement and bonding together of a set of components to form a Wnt-Frizzled-LRP5/6 complex. go.json Frizzled-LRP5/6 complex assembly|Frizzled-LRP5/6 complex formation|WNT-FZD-LRP5 complex assembly|WNT-FZD-LRP5 complex formation|WNT-FZD-LRP6 complex assembly|WNT-FZD-LRP6 complex formation|Wnt receptor complex assembly|Wnt-FZD-LRP5/6 trimeric complex assembly|Wnt-FZD-LRP5/6 trimeric complex formation|Wnt-induced Frizzled-LRP5/6 complex assembly|Wnt-induced Frizzled-LRP5/6 complex formation http://purl.obolibrary.org/obo/GO_1904701 GO:1904700 biolink:BiologicalProcess granulosa cell apoptotic process Any apoptotic process in a granulosa cell. go.json granulosa cell apoptosis|granulosa cell of ovary apoptosis|granulosa cell of ovary apoptotic process http://purl.obolibrary.org/obo/GO_1904700 GO:0072056 biolink:BiologicalProcess pyramid development The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts. go.json kidney pyramid development|pyramids development|renal medulla development|renal pyramid development http://purl.obolibrary.org/obo/GO_0072056 GO:0072055 biolink:BiologicalProcess renal cortex development The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072055 GO:0047099 biolink:MolecularActivity CDP-4-dehydro-6-deoxyglucose reductase activity Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose. EC:1.17.1.1|MetaCyc:1.17.1.1-RXN go.json CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity|CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity|CDP-4-keto-6-deoxyglucose reductase activity|CDP-4-keto-deoxy-glucose reductase activity|NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity|cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity|cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity http://purl.obolibrary.org/obo/GO_0047099 GO:0072054 biolink:BiologicalProcess renal outer medulla development The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla. go.json outer renal medulla development http://purl.obolibrary.org/obo/GO_0072054 GO:0047098 biolink:MolecularActivity Latia-luciferin monooxygenase (demethylating) activity Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin. EC:1.14.99.21|MetaCyc:1.14.99.21-RXN|RHEA:12677 go.json Latia luciferin monooxygenase (demethylating)|Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)|luciferase (Latia luciferin) http://purl.obolibrary.org/obo/GO_0047098 GO:0072053 biolink:BiologicalProcess renal inner medulla development The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney. go.json inner renal medulla development http://purl.obolibrary.org/obo/GO_0072053 GO:0047097 biolink:MolecularActivity phylloquinone monooxygenase (2,3-epoxidizing) activity Catalysis of the reaction: AH(2) + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O. EC:1.14.99.20|KEGG_REACTION:R03510|MetaCyc:1.14.99.20-RXN|RHEA:16745 go.json phylloquinone epoxidase activity|phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)|vitamin K 2,3-epoxidase activity|vitamin K epoxidase activity|vitamin K1 epoxidase activity http://purl.obolibrary.org/obo/GO_0047097 GO:0047096 biolink:MolecularActivity androst-4-ene-3,17-dione monooxygenase activity Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone. EC:1.14.99.12|KEGG_REACTION:R01833|MetaCyc:1.14.99.12-RXN|RHEA:22696 go.json 4-androstene-3,17-dione monooxygenase activity|androst-4-ene-3,17-dione 17-oxidoreductase activity|androst-4-ene-3,17-dione hydroxylase activity|androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)|androstene-3,17-dione hydroxylase activity|androstenedione monooxygenase activity http://purl.obolibrary.org/obo/GO_0047096 GO:0072052 biolink:BiologicalProcess juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072052 GO:0047095 biolink:MolecularActivity 2-hydroxycyclohexanone 2-monooxygenase activity Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP+. EC:1.14.13.66|KEGG_REACTION:R03281|MetaCyc:1.14.13.66-RXN|RHEA:33283 go.json 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing) http://purl.obolibrary.org/obo/GO_0047095 GO:0072051 biolink:BiologicalProcess juxtaglomerular apparatus development The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function. go.json http://purl.obolibrary.org/obo/GO_0072051 GO:0047094 biolink:MolecularActivity 3-hydroxyphenylacetate 6-hydroxylase activity Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate. EC:1.14.13.63|MetaCyc:1.14.13.63-RXN go.json 3-hydroxyphenylacetate 6-monooxygenase activity|3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating) http://purl.obolibrary.org/obo/GO_0047094 GO:0072050 biolink:BiologicalProcess S-shaped body morphogenesis The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron. go.json http://purl.obolibrary.org/obo/GO_0072050 GO:0047093 biolink:MolecularActivity 4-hydroxyquinoline 3-monooxygenase activity Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol. EC:1.14.13.62|KEGG_REACTION:R05154|MetaCyc:1.14.13.62-RXN|RHEA:19325 go.json 1-H-4-oxoquinoline 3-monooxygenase activity|quinolin-4(1H)-one 3-monooxygenase activity|quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating) http://purl.obolibrary.org/obo/GO_0047093 GO:0072059 biolink:BiologicalProcess cortical collecting duct development The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex. go.json http://purl.obolibrary.org/obo/GO_0072059 GO:0072058 biolink:BiologicalProcess outer stripe development The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region. go.json http://purl.obolibrary.org/obo/GO_0072058 GO:0072057 biolink:BiologicalProcess inner stripe development The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle. go.json http://purl.obolibrary.org/obo/GO_0072057 GO:0072045 biolink:BiologicalProcess convergent extension involved in nephron morphogenesis The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron. go.json http://purl.obolibrary.org/obo/GO_0072045 GO:0072044 biolink:BiologicalProcess collecting duct development The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. go.json http://purl.obolibrary.org/obo/GO_0072044 GO:0072043 biolink:BiologicalProcess regulation of pre-tubular aggregate formation by cell-cell signaling Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney. go.json regulation of pre-tubular aggregate formation by cell-cell signalling http://purl.obolibrary.org/obo/GO_0072043 GO:0072042 biolink:BiologicalProcess regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron. go.json http://purl.obolibrary.org/obo/GO_0072042 GO:0072041 biolink:BiologicalProcess positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. go.json positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis|positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072041 GO:0072040 biolink:BiologicalProcess negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. go.json negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis|negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072040 GO:0072049 biolink:BiologicalProcess comma-shaped body morphogenesis The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron. go.json http://purl.obolibrary.org/obo/GO_0072049 GO:0072048 biolink:BiologicalProcess renal system pattern specification Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system. go.json renal system pattern formation http://purl.obolibrary.org/obo/GO_0072048 gocheck_do_not_annotate GO:0072047 biolink:BiologicalProcess proximal/distal pattern formation involved in nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). go.json proximal-distal pattern formation involved in nephron development|proximal/distal nephron patterning http://purl.obolibrary.org/obo/GO_0072047 GO:0072046 biolink:BiologicalProcess establishment of planar polarity involved in nephron morphogenesis Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron. go.json establishment of planar cell polarity involved in nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072046 GO:0072078 biolink:BiologicalProcess nephron tubule morphogenesis The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072078 GO:0072077 biolink:BiologicalProcess renal vesicle morphogenesis The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072077 GO:0072076 biolink:BiologicalProcess nephrogenic mesenchyme development The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron. go.json http://purl.obolibrary.org/obo/GO_0072076 GO:0072075 biolink:BiologicalProcess metanephric mesenchyme development The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072075 GO:0072074 biolink:BiologicalProcess kidney mesenchyme development The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. go.json http://purl.obolibrary.org/obo/GO_0072074 GO:0072073 biolink:BiologicalProcess kidney epithelium development The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. go.json http://purl.obolibrary.org/obo/GO_0072073 GO:0072072 biolink:BiologicalProcess kidney stroma development The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney. go.json http://purl.obolibrary.org/obo/GO_0072072 GO:0072071 biolink:BiologicalProcess kidney interstitial fibroblast differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state. go.json kidney interstitial cell differentiation http://purl.obolibrary.org/obo/GO_0072071 GO:0072070 biolink:BiologicalProcess loop of Henle development The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. go.json intermediate tubule development http://purl.obolibrary.org/obo/GO_0072070 GO:0072079 biolink:BiologicalProcess nephron tubule formation The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072079 GO:0072067 biolink:BiologicalProcess early distal convoluted tubule development The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive. go.json http://purl.obolibrary.org/obo/GO_0072067 GO:0072066 biolink:BiologicalProcess prebend segment development The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability. go.json http://purl.obolibrary.org/obo/GO_0072066 GO:0072065 biolink:BiologicalProcess long descending thin limb bend development The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment. go.json http://purl.obolibrary.org/obo/GO_0072065 GO:0072064 biolink:BiologicalProcess long descending thin limb development The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla. go.json http://purl.obolibrary.org/obo/GO_0072064 GO:0072063 biolink:BiologicalProcess short descending thin limb development The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology. go.json http://purl.obolibrary.org/obo/GO_0072063 GO:0072062 biolink:BiologicalProcess proximal convoluted tubule segment 1 cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state. go.json S1 cell differentiation http://purl.obolibrary.org/obo/GO_0072062 GO:0072061 biolink:BiologicalProcess inner medullary collecting duct development The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla. go.json http://purl.obolibrary.org/obo/GO_0072061 GO:0072060 biolink:BiologicalProcess outer medullary collecting duct development The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla. go.json http://purl.obolibrary.org/obo/GO_0072060 GO:0072069 biolink:BiologicalProcess DCT cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state. go.json distal convoluted tubule cell differentiation http://purl.obolibrary.org/obo/GO_0072069 GO:0072068 biolink:BiologicalProcess late distal convoluted tubule development The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive. go.json http://purl.obolibrary.org/obo/GO_0072068 GO:0072099 biolink:BiologicalProcess anterior/posterior pattern specification involved in ureteric bud development The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. go.json ureteric bud anterior/posterior pattern formation http://purl.obolibrary.org/obo/GO_0072099 GO:0072098 biolink:BiologicalProcess anterior/posterior pattern specification involved in kidney development The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. go.json anterior/posterior pattern formation involved in kidney development|kidney anterior/posterior pattern formation|kidney anterior/posterior pattern specification http://purl.obolibrary.org/obo/GO_0072098 GO:0072097 biolink:BiologicalProcess obsolete negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis. go.json negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway True http://purl.obolibrary.org/obo/GO_0072097 GO:0072096 biolink:BiologicalProcess negative regulation of branch elongation involved in ureteric bud branching Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis. go.json http://purl.obolibrary.org/obo/GO_0072096 GO:0072095 biolink:BiologicalProcess regulation of branch elongation involved in ureteric bud branching Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis. go.json http://purl.obolibrary.org/obo/GO_0072095 GO:0072094 biolink:BiologicalProcess metanephric renal vesicle induction Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle. go.json positive regulation of metanephros formation http://purl.obolibrary.org/obo/GO_0072094 GO:0072093 biolink:BiologicalProcess metanephric renal vesicle formation The developmental process pertaining to the initial formation of the metanephros. go.json metanephros formation http://purl.obolibrary.org/obo/GO_0072093 GO:0072092 biolink:BiologicalProcess ureteric bud invasion The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072092 GO:0072091 biolink:BiologicalProcess regulation of stem cell proliferation Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. go.json http://purl.obolibrary.org/obo/GO_0072091 GO:0072090 biolink:BiologicalProcess mesenchymal stem cell proliferation involved in nephron morphogenesis The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron. go.json http://purl.obolibrary.org/obo/GO_0072090 GO:0072089 biolink:BiologicalProcess stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. go.json http://purl.obolibrary.org/obo/GO_0072089 GO:0072088 biolink:BiologicalProcess nephron epithelium morphogenesis The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron. go.json http://purl.obolibrary.org/obo/GO_0072088 GO:0072087 biolink:BiologicalProcess renal vesicle development The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072087 GO:0072086 biolink:BiologicalProcess specification of loop of Henle identity The process in which the loop of Henle of the kidney nephron acquires its identity. go.json specification of intermediate tubule identity http://purl.obolibrary.org/obo/GO_0072086 GO:0072085 biolink:BiologicalProcess specification of connecting tubule identity The process in which the connecting tubule of the kidney nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072085 GO:0072084 biolink:BiologicalProcess specification of distal tubule identity The process in which the distal tubule of the kidney nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072084 GO:0072083 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072083 GO:0072082 biolink:BiologicalProcess specification of proximal tubule identity The process in which the proximal tubule of the kidney nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072082 GO:0072081 biolink:BiologicalProcess specification of nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0072081 GO:0072080 biolink:BiologicalProcess nephron tubule development The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072080 GO:0023045 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023045 GO:0047012 biolink:MolecularActivity sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one. EC:1.1.1.170|MetaCyc:1.1.1.170-RXN go.json 3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity|3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity|3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity|3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)|sterol 4-alpha-carboxylic decarboxylase activity http://purl.obolibrary.org/obo/GO_0047012 GO:0047011 biolink:MolecularActivity 2-dehydropantolactone reductase (A-specific) activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. EC:1.1.1.168|MetaCyc:1.1.1.168-RXN go.json (R)-pantolactone:NADP+ oxidoreductase (A-specific)|2-dehydropantoyl-lactone reductase (A-specific) activity|2-ketopantoyl lactone reductase activity|2-oxopantoyl lactone reductase|ketopantoyl lactone reductase activity http://purl.obolibrary.org/obo/GO_0047011 GO:0023044 biolink:BiologicalProcess obsolete signaling via chemical mediator OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator. go.json signaling via chemical mediator|signalling via chemical mediator True http://purl.obolibrary.org/obo/GO_0023044 GO:0047010 biolink:MolecularActivity hydroxycyclohexanecarboxylate dehydrogenase activity Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH. EC:1.1.1.166|KEGG_REACTION:R05315|MetaCyc:1.1.1.166-RXN|RHEA:10516 go.json (-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity|(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity|dihydroxycyclohexanecarboxylate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047010 GO:0023047 biolink:BiologicalProcess obsolete signal initiation by chemical mediator OBSOLETE. The process in which a chemical signal causes activation of a receptor. go.json signal initiation by chemical mediator True http://purl.obolibrary.org/obo/GO_0023047 GO:0023046 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023046 GO:0023049 biolink:BiologicalProcess obsolete signal initiation by protein/peptide mediator OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor. go.json signal initiation by protein/peptide mediator True http://purl.obolibrary.org/obo/GO_0023049 GO:0023048 biolink:BiologicalProcess obsolete signal initiation by lipid mediator OBSOLETE. The process in which a lipid signal causes activation of a receptor. go.json signal initiation by lipid mediator True http://purl.obolibrary.org/obo/GO_0023048 GO:0047019 biolink:MolecularActivity indole-3-acetaldehyde reductase (NADPH) activity Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH. EC:1.1.1.191|KEGG_REACTION:R02680|MetaCyc:1.1.1.191-RXN|RHEA:17037 go.json (indol-3-yl)ethanol:NADP+ oxidoreductase activity|indole-3-ethanol:NADP+ oxidoreductase activity|indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity http://purl.obolibrary.org/obo/GO_0047019 GO:0047018 biolink:MolecularActivity indole-3-acetaldehyde reductase (NADH) activity Catalysis of the reaction: indole-3-ethanol + NAD+ = (indol-3-yl)acetaldehyde + H+ + NADH. EC:1.1.1.190|KEGG_REACTION:R02679|MetaCyc:1.1.1.190-RXN|RHEA:14873 go.json (indol-3-yl)ethanol:NAD+ oxidoreductase activity|indole-3-ethanol:NAD+ oxidoreductase activity|indoleacetaldehyde reductase activity http://purl.obolibrary.org/obo/GO_0047018 GO:0047017 biolink:MolecularActivity prostaglandin-F synthase activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. EC:1.1.1.188|MetaCyc:1.1.1.188-RXN|RHEA:10140 go.json (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity|NADPH-dependent prostaglandin D2 11-keto reductase activity|PGD(2) 11-ketoreductase activity|PGD2 11-ketoreductase activity|PGF synthetase activity|PGF2alpha synthetase activity|prostaglandin 11-keto reductase activity|prostaglandin 11-ketoreductase activity|prostaglandin D2-ketoreductase activity|prostaglandin F synthase activity|prostaglandin F synthetase activity|prostaglandin-D(2) 11-ketoreductase activity|prostaglandin-D(2) 11-reductase activity|prostaglandin-D(2) ketoreductase activity|prostaglandin-D2 11-ketoreductase activity|prostaglandin-D2 11-reductase activity|prostaglandin-D2 ketoreductase activity|prostaglandin-F synthetase activity|reductase, 15-hydroxy-11-oxoprostaglandin|synthetase, prostaglandin F2alpha http://purl.obolibrary.org/obo/GO_0047017 GO:0047016 biolink:MolecularActivity cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. EC:1.1.1.181|MetaCyc:1.1.1.181-RXN|RHEA:11896 go.json 3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity|3beta-hydroxy-delta5-C27-steroid oxidoreductase|cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity|cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047016 GO:0023041 biolink:BiologicalProcess neuronal signal transduction The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular. go.json http://purl.obolibrary.org/obo/GO_0023041 GO:0023040 biolink:BiologicalProcess obsolete signaling via ionic flux OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux. go.json signaling via ionic flux|signalling via ionic flux True http://purl.obolibrary.org/obo/GO_0023040 GO:0047015 biolink:MolecularActivity 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. EC:1.1.1.178|MetaCyc:1.1.1.178-RXN|RHEA:13281 go.json (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity|2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity|2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity|2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047015 GO:0047014 biolink:MolecularActivity glycerol-3-phosphate 1-dehydrogenase [NADP+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH. EC:1.1.1.177|KEGG_REACTION:R00845|MetaCyc:1.1.1.177-RXN|RHEA:19773 go.json L-glycerol 3-phosphate:NADP oxidoreductase activity|NADPH-dependent glycerin-3-phosphate dehydrogenase activity|glycerin-3-phosphate dehydrogenase activity|glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047014 GO:0023043 biolink:BiologicalProcess obsolete signaling via lipid mediator OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator. go.json signaling via lipid mediator|signalling via lipid mediator True http://purl.obolibrary.org/obo/GO_0023043 GO:0047013 biolink:MolecularActivity cholate 12-alpha dehydrogenase activity Catalysis of the reaction: cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH. EC:1.1.1.176|KEGG_REACTION:R02793|MetaCyc:1.1.1.176-RXN|RHEA:14129 go.json 12-alpha-hydroxysteroid dehydrogenase activity|12alpha-hydroxy steroid dehydrogenase activity|12alpha-hydroxysteroid dehydrogenase activity|12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity|NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity|NADP-12alpha-hydroxysteroid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047013 GO:0023042 biolink:BiologicalProcess obsolete signaling via protein/peptide mediator OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator. go.json signaling via protein/peptide mediator|signalling via protein/peptide mediator True http://purl.obolibrary.org/obo/GO_0023042 GO:0047023 biolink:MolecularActivity androsterone dehydrogenase activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. EC:1.1.1.209|MetaCyc:1.1.1.209-RXN go.json 3(17)alpha-hydroxysteroid dehydrogenase activity|3(or 17)-alpha-hydroxysteroid dehydrogenase activity|3(or 17)alpha-hydroxysteroid dehydrogenase activity|3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047023 GO:0023034 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023034 GO:0047022 biolink:MolecularActivity 7-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid. EC:1.1.1.201|MetaCyc:1.1.1.201-RXN|RHEA:20233|Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+) go.json 7beta-hydroxysteroid dehydrogenase (NADP+)|7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity|NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity|NADP-dependent 7beta-hydroxysteroid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047022 GO:0023033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023033 GO:0047021 biolink:MolecularActivity 15-hydroxyprostaglandin dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH. EC:1.1.1.197|KEGG_REACTION:R04552|MetaCyc:1.1.1.197-RXN|RHEA:11636 go.json (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity|NADP-dependent 15-hydroxyprostaglandin dehydrogenase|NADP-linked 15-hydroxyprostaglandin dehydrogenase|NADP-specific 15-hydroxyprostaglandin dehydrogenase|type II 15-hydroxyprostaglandin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047021 GO:0023036 biolink:BiologicalProcess obsolete initiation of signal transduction OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change. go.json initiation of signal transduction|signal reception True http://purl.obolibrary.org/obo/GO_0023036 GO:0023035 biolink:BiologicalProcess CD40 signaling pathway The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json CD40 signalling pathway http://purl.obolibrary.org/obo/GO_0023035 GO:0047020 biolink:MolecularActivity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. EC:1.1.1.196|MetaCyc:1.1.1.196-RXN|RHEA:20744 go.json (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity|15-hydroxy PGD2 dehydrogenase activity|15-hydroxyprostaglandin dehydrogenase (NADP)|NADP-PGD2 dehydrogenase activity|NADP-dependent 15-hydroxyprostaglandin dehydrogenase|NADP-linked 15-hydroxyprostaglandin dehydrogenase|NADP-linked prostaglandin D2 dehydrogenase activity|NADP-specific 15-hydroxyprostaglandin dehydrogenase|dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)|dehydrogenase, prostaglandin D2|prostaglandin D2 dehydrogenase activity|prostaglandin-D 15-dehydrogenase (NADP(+)) activity|prostaglandin-D 15-dehydrogenase (NADP)|prostaglandin-D 15-dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0047020 GO:0023038 biolink:BiologicalProcess obsolete signal initiation by diffusible mediator OBSOLETE. The process in which a diffusible signal causes activation of a receptor. go.json signal initiation by diffusible mediator True http://purl.obolibrary.org/obo/GO_0023038 GO:0023037 biolink:BiologicalProcess obsolete signal initiation by light OBSOLETE. The process in which a light signal causes activation of a receptor. go.json signal initiation by light True http://purl.obolibrary.org/obo/GO_0023037 GO:0023039 biolink:BiologicalProcess obsolete signal initiation by physical damage OBSOLETE. The process in which a physical damage signal causes activation of a receptor. go.json signal initiation by physical damage True http://purl.obolibrary.org/obo/GO_0023039 GO:0047029 biolink:MolecularActivity (R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate. MetaCyc:RXN-7632|RHEA:52692|https://github.com/geneontology/go-ontology/issues/21412 go.json aromatic 2-oxoacid reductase activity|hydroxyphenylpyruvate reductase activity|phenylpyruvate reductase activity http://purl.obolibrary.org/obo/GO_0047029 GO:0047028 biolink:MolecularActivity 6-pyruvoyltetrahydropterin 2'-reductase activity Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin. EC:1.1.1.220|MetaCyc:1.1.1.220-RXN|RHEA:11772 go.json 6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity|6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity|6-pyruvoyl-tetrahydropterin 2'-reductase activity|6-pyruvoyltetrahydropterin reductase activity|6PPH4(2'-oxo) reductase activity|pyruvoyl-tetrahydropterin reductase activity http://purl.obolibrary.org/obo/GO_0047028 GO:0047027 biolink:MolecularActivity benzyl-2-methyl-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + H+ + NADPH. EC:1.1.1.217|KEGG_REACTION:R04370|MetaCyc:1.1.1.217-RXN|RHEA:16405 go.json benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity|benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047027 GO:0023030 biolink:MolecularActivity MHC class Ib protein binding, via antigen binding groove Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove. go.json http://purl.obolibrary.org/obo/GO_0023030 GO:0047026 biolink:MolecularActivity androsterone dehydrogenase (A-specific) activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. EC:1.1.1.213|MetaCyc:1.1.1.213-RXN|Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific) go.json 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity|3alpha-hydroxysteroid dehydrogenase (A-specific)|3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific) http://purl.obolibrary.org/obo/GO_0047026 GO:0047025 biolink:MolecularActivity 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]. EC:1.1.1.212|MetaCyc:1.1.1.212-RXN|RHEA:19913 go.json (3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity|3-oxoacyl-ACP reductase (NADH) activity|3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity|3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity|3-oxoacyl-acyl-carrier-protein reductase (NADH) http://purl.obolibrary.org/obo/GO_0047025 GO:0023032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023032 GO:0023031 biolink:MolecularActivity MHC class Ib protein binding, via lateral surface Binding to a major histocompatibility complex class Ib molecules via the lateral surface. go.json http://purl.obolibrary.org/obo/GO_0023031 GO:0047024 biolink:MolecularActivity 5alpha-androstane-3beta,17beta-diol dehydrogenase activity Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH. EC:1.1.1.210|KEGG_REACTION:R04344|MetaCyc:1.1.1.210-RXN|RHEA:16297 go.json 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity|3-beta-HSD activity|3beta(or 20alpha)-hydroxysteroid dehydrogenase activity|3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity|3beta,20alpha-hydroxysteroid oxidoreductase activity|dehydrogenase, 3beta,20alpha-hydroxy steroid|progesterone reductase activity http://purl.obolibrary.org/obo/GO_0047024 GO:0047034 biolink:MolecularActivity 15-hydroxyicosatetraenoate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate. EC:1.1.1.232|MetaCyc:1.1.1.232-RXN|Reactome:R-HSA-2161789 go.json (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity|15-hydroxyeicosatetraenoate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047034 GO:0023023 biolink:MolecularActivity MHC protein complex binding Binding to a major histocompatibility complex. go.json http://purl.obolibrary.org/obo/GO_0023023 GO:0023022 biolink:BiologicalProcess termination of T cell signal transduction The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated. go.json http://purl.obolibrary.org/obo/GO_0023022 GO:0047033 biolink:MolecularActivity 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH. EC:1.1.1.231|KEGG_REACTION:R03520|MetaCyc:1.1.1.231-RXN|RHEA:21420 go.json (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity|NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity|NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity|PG I2 dehydrogenase activity|prostacyclin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047033 GO:0023025 biolink:MolecularActivity MHC class Ib protein complex binding Binding to a class Ib major histocompatibility complex. go.json http://purl.obolibrary.org/obo/GO_0023025 GO:0047032 biolink:MolecularActivity 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH. EC:1.1.1.230|KEGG_REACTION:R04099|MetaCyc:1.1.1.230-RXN|RHEA:20816 go.json 3alpha-hydroxyglycyrrhetinate dehydrogenase activity|3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047032 GO:0023024 biolink:MolecularActivity MHC class I protein complex binding Binding to a class I major histocompatibility complex. go.json http://purl.obolibrary.org/obo/GO_0023024 GO:0047031 biolink:MolecularActivity diethyl 2-methyl-3-oxosuccinate reductase activity Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH. EC:1.1.1.229|KEGG_REACTION:R04387|MetaCyc:1.1.1.229-RXN|RHEA:21008 go.json diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047031 GO:0047030 biolink:MolecularActivity 4-hydroxycyclohexanecarboxylate dehydrogenase activity Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD+ = 4-oxocyclohexanecarboxylate + H+ + NADH. EC:1.1.1.226|KEGG_REACTION:R04307|MetaCyc:1.1.1.226-RXN|RHEA:17429 go.json trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity|trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047030 GO:0023027 biolink:MolecularActivity MHC class I protein binding, via antigen binding groove Binding to a major histocompatibility complex class I molecules via the antigen binding groove. go.json http://purl.obolibrary.org/obo/GO_0023027 GO:0023026 biolink:MolecularActivity MHC class II protein complex binding Binding to a class II major histocompatibility complex. go.json http://purl.obolibrary.org/obo/GO_0023026 GO:0023029 biolink:MolecularActivity MHC class Ib protein binding Binding to a major histocompatibility complex class Ib molecules. go.json http://purl.obolibrary.org/obo/GO_0023029 GO:0023028 biolink:MolecularActivity MHC class I protein binding, via lateral surface Binding to a major histocompatibility complex class I molecules via the lateral surface. go.json http://purl.obolibrary.org/obo/GO_0023028 GO:0047039 biolink:MolecularActivity tetrahydroxynaphthalene reductase activity Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol. EC:1.1.1.252|MetaCyc:1.1.1.252-RXN|RHEA:21908 go.json T4HN reductase activity|scytalone:NADP+ delta5-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047039 GO:0047038 biolink:MolecularActivity D-arabinitol 2-dehydrogenase activity Catalysis of the reaction: D-arabinitol + NAD+ = D-ribulose + H+ + NADH. EC:1.1.1.250|KEGG_REACTION:R07134|MetaCyc:1.1.1.250-RXN|RHEA:17389 go.json D-arabinitol 2-dehydrogenase (ribulose-forming) activity|D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming) http://purl.obolibrary.org/obo/GO_0047038 GO:0047037 biolink:MolecularActivity salutaridine reductase (NADPH) activity Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine. EC:1.1.1.248|KEGG_REACTION:R04697|MetaCyc:1.1.1.248-RXN|RHEA:10108 go.json salutaridinol:NADP+ 7-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047037 GO:0047036 biolink:MolecularActivity codeinone reductase (NADPH) activity Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH. EC:1.1.1.247|KEGG_REACTION:R05124|MetaCyc:1.1.1.247-RXN|RHEA:19209 go.json codeine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047036 GO:0023021 biolink:BiologicalProcess termination of signal transduction The signaling process in which signal transduction is brought to an end rather than being reversibly modulated. go.json http://purl.obolibrary.org/obo/GO_0023021 GO:0047035 biolink:MolecularActivity testosterone dehydrogenase (NAD+) activity Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. EC:1.1.1.239|KEGG_REACTION:R01836|MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN|RHEA:14929|Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+) go.json 17-beta-HSD activity|17-ketoreductase activity|17beta-HSD|17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity|3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity|3alpha(17beta)-HSD|3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)|3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity|3alpha,17beta-hydroxy steroid dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17b-dehydrogenase activity|testosterone 17beta-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047035 GO:0023020 biolink:BiologicalProcess obsolete regulation of gene expression as a consequence of T cell signal transmission OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another. go.json regulation of gene expression as a consequence of T cell signal transmission True http://purl.obolibrary.org/obo/GO_0023020 GO:0047045 biolink:MolecularActivity testosterone 17-beta-dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. EC:1.1.1.64|KEGG_REACTION:R01838|MetaCyc:1.1.1.64-RXN|RHEA:14981|Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+) go.json 17-ketoreductase activity|17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity|NADP-dependent testosterone-17beta-oxidoreductase activity|testosterone 17beta-dehydrogenase (NADP+) http://purl.obolibrary.org/obo/GO_0047045 GO:0023012 biolink:BiologicalProcess obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling. go.json initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor|initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor True http://purl.obolibrary.org/obo/GO_0023012 GO:0047044 biolink:MolecularActivity androstan-3-alpha,17-beta-diol dehydrogenase activity Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. EC:1.1.1.53|MetaCyc:1.1.1.53-RXN|RHEA:22400 go.json (R)-20-hydroxysteroid dehydrogenase activity|20beta-HSD|20beta-hydroxysteroid dehydrogenase activity|3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity|3alpha(or 20beta)-hydroxysteroid dehydrogenase activity|3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity|3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity|NADH-20beta-hydroxysteroid dehydrogenase activity|cortisone reductase activity|dehydrogenase, 20beta-hydroxy steroid|delta4-3-ketosteroid hydrogenase activity http://purl.obolibrary.org/obo/GO_0047044 GO:0023011 biolink:BiologicalProcess obsolete positive regulation of initiation of T cell receptor signaling OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling. go.json positive regulation of initiation of T cell receptor signaling|positive regulation of initiation of T cell receptor signalling True http://purl.obolibrary.org/obo/GO_0023011 GO:0023014 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023014 GO:0047043 biolink:MolecularActivity 3-alpha-hydroxycholanate dehydrogenase activity Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH. EC:1.1.1.52|KEGG_REACTION:R04139|MetaCyc:1.1.1.52-RXN|RHEA:19585 go.json 3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity|3alpha-hydroxycholanate dehydrogenase activity|alpha-hydroxy-cholanate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047043 GO:0047042 biolink:MolecularActivity androsterone dehydrogenase (B-specific) activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. EC:1.1.1.50|MetaCyc:1.1.1.209-RXN|Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific) go.json 3-alpha-HSD activity|3-alpha-hydroxysteroid dehydrogenase (B-specific) activity|3alpha-HSD|3alpha-hydroxysteroid dehydrogenase (B-specific)|3alpha-hydroxysteroid oxidoreductase activity|3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)|hydroxyprostaglandin dehydrogenase activity|sterognost 3alpha http://purl.obolibrary.org/obo/GO_0047042 GO:0023013 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023013 GO:0023016 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023016 GO:0047041 biolink:MolecularActivity (S)-carnitine 3-dehydrogenase activity Catalysis of the reaction: (S)-carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH. EC:1.1.1.254|KEGG_REACTION:R01921|MetaCyc:1.1.1.254-RXN|RHEA:11556 go.json (S)-carnitine:NAD+ oxidoreductase activity|D-carnitine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047041 GO:0023015 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0023015 GO:0047040 biolink:MolecularActivity pteridine reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH. EC:1.5.1.33|KEGG_REACTION:R01812|MetaCyc:1.1.1.253-RXN|RHEA:19509 go.json 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity|PTR1|dihydrobiopterin reduction|pteridine reductase 1 activity|ptr1 activity http://purl.obolibrary.org/obo/GO_0047040 GO:0023018 biolink:BiologicalProcess obsolete T cell activation of signal transmission via diffusible molecule OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell. go.json T cell activation of signal transmission via diffusible molecule True http://purl.obolibrary.org/obo/GO_0023018 GO:0023017 biolink:BiologicalProcess obsolete signal transmission via diffusible molecule OBSOLETE. The process in which a signal is conveyed via a diffusible molecule. go.json signal transmission via diffusible molecule|signaling via diffusible mediator True http://purl.obolibrary.org/obo/GO_0023017 GO:0047049 biolink:MolecularActivity (R)-2-hydroxy-fatty acid dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH. EC:1.1.1.98|KEGG_REACTION:R03021|MetaCyc:1.1.1.98-RXN|RHEA:15949 go.json (R)-2-hydroxy-fatty-acid dehydrogenase activity|(R)-2-hydroxystearate:NAD+ oxidoreductase activity|2-hydroxy fatty acid oxidase|D-2-hydroxy fatty acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047049 GO:0047048 biolink:MolecularActivity 3-hydroxybenzyl-alcohol dehydrogenase activity Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + H+ + NADPH. EC:1.1.1.97|KEGG_REACTION:R04136|MetaCyc:1.1.1.97-RXN|RHEA:22340 go.json 3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity|m-hydroxybenzyl alcohol (NADP) dehydrogenase activity|m-hydroxybenzyl alcohol dehydrogenase activity|m-hydroxybenzylalcohol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047048 GO:0047047 biolink:MolecularActivity oxaloglycolate reductase (decarboxylating) activity Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate. EC:1.1.1.92|MetaCyc:1.1.1.92-RXN go.json D-glycerate:NAD(P)+ oxidoreductase (carboxylating) http://purl.obolibrary.org/obo/GO_0047047 GO:0023010 biolink:BiologicalProcess obsolete regulation of initiation of T cell receptor signaling OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling. go.json regulation of initiation of T cell receptor signaling|regulation of initiation of T cell receptor signalling True http://purl.obolibrary.org/obo/GO_0023010 GO:0047046 biolink:MolecularActivity homoisocitrate dehydrogenase activity Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate. EC:1.1.1.87|MetaCyc:RXN-7970|RHEA:11900 go.json (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity|(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)|(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)|2-hydroxy-3-carboxyadipate dehydrogenase activity|3-carboxy-2-hydroxyadipate dehydrogenase activity|3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity|3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)|homoisocitric dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047046 GO:0023019 biolink:BiologicalProcess signal transduction involved in regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. go.json regulation of gene expression as a consequence of signal transmission http://purl.obolibrary.org/obo/GO_0023019 GO:0047056 biolink:MolecularActivity (S)-canadine synthase activity Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. EC:1.14.19.68|KEGG_REACTION:R04400|MetaCyc:1.1.3.36-RXN|RHEA:21456 go.json (S)-tetrahydroberberine synthase activity|(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity http://purl.obolibrary.org/obo/GO_0047056 GO:0072012 biolink:BiologicalProcess glomerulus vasculature development The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. go.json glomerulus capillary development http://purl.obolibrary.org/obo/GO_0072012 GO:0047055 biolink:MolecularActivity salutaridine synthase activity Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. EC:1.14.19.67|KEGG_REACTION:R04696|MetaCyc:1.1.3.35-RXN|RHEA:17713 go.json (R)-reticuline oxidase (C-C phenol-coupling) activity http://purl.obolibrary.org/obo/GO_0047055 GO:0072011 biolink:BiologicalProcess glomerular endothelium development The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072011 GO:0072010 biolink:BiologicalProcess glomerular epithelium development The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072010 GO:0023003 biolink:BiologicalProcess nuclear migration to the embryo sac center Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell. go.json nuclear migration to the embryo sac centre|nuclear migration to the female gametophyte center|nuclear migration to the female gametophyte centre|nuclear migration to the megagametophyte center|nuclear migration to the megagametophyte centre|nucleus migration to the female gametophyte center|nucleus migration to the female gametophyte centre http://purl.obolibrary.org/obo/GO_0023003 GO:0047054 biolink:MolecularActivity berbamunine synthase activity Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. EC:1.14.19.66|MetaCyc:1.1.3.34-RXN|RHEA:23576 go.json heme-thiolate http://purl.obolibrary.org/obo/GO_0047054 GO:0047053 biolink:MolecularActivity (S)-cheilanthifoline synthase activity Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O. EC:1.14.19.65|KEGG_REACTION:R03834|MetaCyc:1.14.21.2-RXN|RHEA:20485 go.json (S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity|(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming) http://purl.obolibrary.org/obo/GO_0047053 GO:0023002 biolink:BiologicalProcess nuclear migration to embryo sac poles Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell. go.json nuclear migration to female gametophyte poles|nuclear migration to megagametophyte poles|nucleus migration to embryo sac poles|nucleus migration to female gametophyte poles|nucleus migration to megagametophyte poles http://purl.obolibrary.org/obo/GO_0023002 GO:0047052 biolink:MolecularActivity (S)-stylopine synthase activity Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. EC:1.14.19.64|KEGG_REACTION:R04690|MetaCyc:1.1.3.32-RXN|RHEA:13773 go.json (S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity|(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming) http://purl.obolibrary.org/obo/GO_0047052 GO:0023005 biolink:BiologicalProcess obsolete signal initiation by neurotransmitter OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor. go.json signal initiation by neurotransmitter True http://purl.obolibrary.org/obo/GO_0023005 GO:0047051 biolink:MolecularActivity D-lactate dehydrogenase (cytochrome c-553) activity Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate. EC:1.1.2.5|MetaCyc:1.1.2.5-RXN|RHEA:16465 go.json (R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047051 GO:0023004 biolink:BiologicalProcess obsolete activation of dopamine receptor signaling pathway OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor. go.json activation of dopamine receptor signaling pathway|activation of dopamine receptor signalling pathway|initiation of dopamine receptor signaling pathway|stimulation of dopamine receptor signaling pathway True http://purl.obolibrary.org/obo/GO_0023004 GO:0023007 biolink:BiologicalProcess obsolete ligand binding to T cell receptor OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process. go.json ligand binding to T cell receptor True http://purl.obolibrary.org/obo/GO_0023007 GO:0047050 biolink:MolecularActivity (S)-2-hydroxy-fatty acid dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH. EC:1.1.1.99|KEGG_REACTION:R03022|MetaCyc:1.1.1.99-RXN|RHEA:11384 go.json (S)-2-hydroxy-fatty-acid dehydrogenase activity|(S)-2-hydroxystearate:NAD+ oxidoreductase activity|2-hydroxy fatty acid oxidase|L-2-hydroxy fatty acid dehydrogenase activity|dehydrogenase, L-2-hydroxy fatty acid http://purl.obolibrary.org/obo/GO_0047050 GO:0023006 biolink:BiologicalProcess obsolete signal initiation by amino acid OBSOLETE. The process in which an amino acid signal causes activation of a receptor. go.json signal initiation by amino acid True http://purl.obolibrary.org/obo/GO_0023006 GO:0047059 biolink:MolecularActivity polyvinyl alcohol dehydrogenase (cytochrome) activity Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+. EC:1.1.2.6|KEGG_REACTION:R03136|MetaCyc:RXN-11316|RHEA:20157 go.json PVA dehydrogenase activity|polyvinyl alcohol:ferricytochrome-c oxidoreductase activity|polyvinyl-alcohol:(acceptor) oxidoreductase activity|polyvinyl-alcohol:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047059 GO:0047058 biolink:MolecularActivity vitamin-K-epoxide reductase (warfarin-insensitive) activity Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. EC:1.17.4.5|MetaCyc:1.1.4.2-RXN|RHEA:21560 go.json vitamin K 2,3-epoxide reductase activity http://purl.obolibrary.org/obo/GO_0047058 GO:0047057 biolink:MolecularActivity vitamin-K-epoxide reductase (warfarin-sensitive) activity Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues. EC:1.17.4.4|MetaCyc:1.1.4.1-RXN|RHEA:57744|Reactome:R-HSA-159790|Reactome:R-HSA-6806647 go.json phylloquinone epoxide reductase activity|vitamin K1 epoxide reductase activity http://purl.obolibrary.org/obo/GO_0047057 GO:0023009 biolink:BiologicalProcess obsolete initiation of T cell receptor signaling OBSOLETE. The process in which a signal causes activation of T cell receptor signaling. go.json initiation of T cell receptor signaling|initiation of T cell receptor signalling True http://purl.obolibrary.org/obo/GO_0023009 GO:0072019 biolink:BiologicalProcess proximal convoluted tubule development The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule. go.json http://purl.obolibrary.org/obo/GO_0072019 GO:0072018 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072018 GO:0072017 biolink:BiologicalProcess distal tubule development The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. go.json http://purl.obolibrary.org/obo/GO_0072017 GO:0072016 biolink:BiologicalProcess glomerular parietal epithelial cell development The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. go.json Bowman's capsule development http://purl.obolibrary.org/obo/GO_0072016 GO:0072015 biolink:BiologicalProcess podocyte development The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. go.json glomerular visceral epithelial cell development http://purl.obolibrary.org/obo/GO_0072015 GO:0072014 biolink:BiologicalProcess proximal tubule development The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. go.json http://purl.obolibrary.org/obo/GO_0072014 GO:0072013 biolink:BiologicalProcess glomus development The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment. go.json pronephric glomus development http://purl.obolibrary.org/obo/GO_0072013 GO:0047067 biolink:MolecularActivity hydrogen:quinone oxidoreductase activity Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone. EC:1.12.5.1|KEGG_REACTION:R02965|MetaCyc:1.12.5.1-RXN|RHEA:18641 go.json hydrogen-ubiquinone oxidoreductase activity|hydrogen:menaquinone oxidoreductase activity|membrane-bound hydrogenase activity|quinone-reactive Ni/Fe-hydrogenase activity http://purl.obolibrary.org/obo/GO_0047067 GO:0072001 biolink:BiologicalProcess renal system development The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. go.json urinary system development|urinary tract development http://purl.obolibrary.org/obo/GO_0072001 gocheck_do_not_annotate GO:0047066 biolink:MolecularActivity phospholipid-hydroperoxide glutathione peroxidase activity Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O. EC:1.11.1.12|MetaCyc:1.11.1.12-RXN|RHEA:19057|Reactome:R-HSA-9018868|Reactome:R-HSA-9018895|Reactome:R-HSA-9020271|Reactome:R-HSA-9020273 go.json hydroperoxide glutathione peroxidase activity|peroxidation-inhibiting protein activity|phospholipid hydroperoxide glutathione peroxidase activity http://purl.obolibrary.org/obo/GO_0047066 GO:0072000 biolink:BiologicalProcess extracellular polysaccharide catabolic process involved in ascospore release from ascus The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus. go.json ascus catabolic process|ascus endolysis|extracellular polysaccharide breakdown involved in ascospore release from ascus|extracellular polysaccharide catabolism involved in ascospore release from ascus|extracellular polysaccharide degradation involved in ascospore release from ascus http://purl.obolibrary.org/obo/GO_0072000 GO:0047065 biolink:MolecularActivity sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity Catalysis of the reaction: O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O. EC:1.21.3.5|KEGG_REACTION:R00061|MetaCyc:1.10.3.8-RXN|RHEA:22616 go.json sulochrin oxidase activity|sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific) http://purl.obolibrary.org/obo/GO_0047065 GO:0047064 biolink:MolecularActivity sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O. EC:1.21.3.4|KEGG_REACTION:R00060|MetaCyc:1.10.3.7-RXN|RHEA:24092 go.json sulochrin oxidase activity|sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific) http://purl.obolibrary.org/obo/GO_0047064 GO:0047063 biolink:MolecularActivity obsolete L-ascorbate-cytochrome-b5 reductase activity OBSOLETE. Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate. MetaCyc:1.10.2.1-RXN go.json L-ascorbate:ferricytochrome-b5 oxidoreductase activity|ascorbate-cytochrome b5 reductase activity True http://purl.obolibrary.org/obo/GO_0047063 GO:0047062 biolink:MolecularActivity trans-acenaphthene-1,2-diol dehydrogenase activity Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH. EC:1.10.1.1|KEGG_REACTION:R04059|MetaCyc:1.10.1.1-RXN|RHEA:22184 go.json (+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity|trans-1,2-acenaphthenediol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047062 GO:0047061 biolink:MolecularActivity glucose-fructose oxidoreductase activity Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone. EC:1.1.99.28|KEGG_REACTION:R00874|MetaCyc:1.1.99.28-RXN|RHEA:20637 go.json D-glucose:D-fructose oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047061 GO:0047060 biolink:MolecularActivity (R)-pantolactone dehydrogenase (flavin) activity Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2). EC:1.1.99.27|KEGG_REACTION:R03156|MetaCyc:1.1.99.27-RXN|RHEA:21004 go.json (R)-pantolactone:acceptor oxidoreductase (flavin-containing)|(R)-pantoyllactone dehydrogenase (flavin) activity|2-dehydropantolactone reductase (flavin) activity|2-dehydropantoyl-lactone reductase (flavin) activity http://purl.obolibrary.org/obo/GO_0047060 GO:0047069 biolink:MolecularActivity 7,8-dihydroxykynurenate 8,8a-dioxygenase activity Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+. EC:1.13.11.10|KEGG_REACTION:R03253|MetaCyc:1.13.11.10-RXN|RHEA:23400 go.json 7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity|7,8-dihydroxykynurenate oxygenase activity|7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)|7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing) http://purl.obolibrary.org/obo/GO_0047069 GO:0047068 biolink:MolecularActivity N5,N10-methenyltetrahydromethanopterin hydrogenase activity Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+. EC:1.12.98.2|KEGG_REACTION:R04455|MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN|RHEA:20017 go.json 5,10-methenyltetrahydromethanopterin hydrogenase activity|H(2)-dependent methylene-H(4)MPT dehydrogenase activity|H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity|H2-dependent methylene-H4MPT dehydrogenase activity|H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity|N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity|N5,N10-methylenetetrahydromethanopterin dehydrogenase activity|hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity|hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity|hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity|nonmetal hydrogenase activity http://purl.obolibrary.org/obo/GO_0047068 GO:0072009 biolink:BiologicalProcess nephron epithelium development The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. go.json http://purl.obolibrary.org/obo/GO_0072009 GO:0047070 biolink:MolecularActivity 3-carboxyethylcatechol 2,3-dioxygenase activity Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. EC:1.13.11.16|MetaCyc:1.13.11.16-RXN|RHEA:23840 go.json 2,3-dihydroxy-beta-phenylpropionate oxygenase activity|2,3-dihydroxy-beta-phenylpropionic dioxygenase activity|3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)|3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047070 GO:0072008 biolink:BiologicalProcess glomerular mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072008 GO:0072007 biolink:BiologicalProcess mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072007 GO:0072006 biolink:BiologicalProcess nephron development The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. go.json nephrogenesis http://purl.obolibrary.org/obo/GO_0072006 GO:0072005 biolink:BiologicalProcess maintenance of kidney identity The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json maintenance of kidney anlage identity http://purl.obolibrary.org/obo/GO_0072005 GO:0072004 biolink:BiologicalProcess kidney field specification The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop. go.json specification of kidney anlage http://purl.obolibrary.org/obo/GO_0072004 GO:0072003 biolink:BiologicalProcess kidney rudiment formation The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json kidney anlage formation http://purl.obolibrary.org/obo/GO_0072003 GO:0072002 biolink:BiologicalProcess Malpighian tubule development The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. go.json http://purl.obolibrary.org/obo/GO_0072002 GO:0047078 biolink:MolecularActivity 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate. EC:1.13.11.47|MetaCyc:1.13.11.47-RXN|RHEA:17949 go.json (1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity|1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity|3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)|3-hydroxy-4(1H)-one, 2,4-dioxygenase activity|3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity|quinoline-3,4-diol 2,4-dioxygenase activity http://purl.obolibrary.org/obo/GO_0047078 GO:0072034 biolink:BiologicalProcess renal vesicle induction Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle. go.json nephron induction|positive regulation of nephron formation http://purl.obolibrary.org/obo/GO_0072034 GO:0072033 biolink:BiologicalProcess renal vesicle formation The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. go.json nephron epithelium formation http://purl.obolibrary.org/obo/GO_0072033 GO:0047077 biolink:MolecularActivity Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin. EC:1.13.12.7|MetaCyc:1.13.12.7-RXN|RHEA:10732 go.json Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)|Photinus pyralis luciferase activity|Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)|Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)|firefly luciferase activity|firefly luciferin luciferase activity|luciferase (firefly luciferin)|luciferase activity http://purl.obolibrary.org/obo/GO_0047077 GO:0072032 biolink:BiologicalProcess proximal convoluted tubule segment 2 development The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride. go.json S2 development http://purl.obolibrary.org/obo/GO_0072032 GO:0047076 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047076 GO:0072031 biolink:BiologicalProcess proximal convoluted tubule segment 1 development The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes. go.json S1 development http://purl.obolibrary.org/obo/GO_0072031 GO:0047075 biolink:MolecularActivity 2,5-dihydroxypyridine 5,6-dioxygenase activity Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate. EC:1.13.11.9|MetaCyc:1.13.11.9-RXN|RHEA:27522|UM-BBD_reactionID:r1443 go.json 2,5-dihydroxypyridine oxygenase activity|2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity|pyridine-2,5-diol dioxygenase activity http://purl.obolibrary.org/obo/GO_0047075 GO:0072030 biolink:BiologicalProcess short nephron development The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb. go.json http://purl.obolibrary.org/obo/GO_0072030 GO:0047074 biolink:MolecularActivity 4-hydroxycatechol 1,2-dioxygenase activity Catalysis of the reaction: benzene-1,2,4-triol + O2 = maleylacetate + 2 H(+). EC:1.13.11.37|MetaCyc:RXN-10137|RHEA:35595 go.json http://purl.obolibrary.org/obo/GO_0047074 GO:0047073 biolink:MolecularActivity 2,4'-dihydroxyacetophenone dioxygenase activity Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+. EC:1.13.11.41|KEGG_REACTION:R01305|MetaCyc:1.13.11.41-RXN|RHEA:24416|UM-BBD_reactionID:r1410 go.json (4-hydroxybenzoyl)methanol oxygenase activity|2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving) http://purl.obolibrary.org/obo/GO_0047073 GO:0047072 biolink:MolecularActivity 2,3-dihydroxybenzoate 2,3-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H+. EC:1.13.11.28|KEGG_REACTION:R01506|MetaCyc:1.13.11.28-RXN|RHEA:15369 go.json 2,3-dihydroxybenzoate 2,3-oxygenase activity|2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing) http://purl.obolibrary.org/obo/GO_0047072 GO:0047071 biolink:MolecularActivity 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+. EC:1.13.11.25|KEGG_REACTION:R04597|MetaCyc:1.13.11.25-RXN|RHEA:21352|UM-BBD_reactionID:r1151 go.json 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)|3-alkylcatechol 2,3-dioxygenase activity|steroid 4,5-dioxygenase activity http://purl.obolibrary.org/obo/GO_0047071 GO:0047079 biolink:MolecularActivity deoxyuridine 1'-dioxygenase activity Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil. EC:1.14.11.10|KEGG_REACTION:R02486|MetaCyc:1.14.11.10-RXN|RHEA:23316 go.json 2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)|pyrimidine-deoxynucleoside 1'-dioxygenase activity|pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity http://purl.obolibrary.org/obo/GO_0047079 GO:0047081 biolink:MolecularActivity 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate. EC:1.14.13.242|MetaCyc:1.14.12.4-RXN|RHEA:10864 go.json 2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity|3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)|3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity|methylhydroxypyridine carboxylate dioxygenase activity|methylhydroxypyridinecarboxylate oxidase activity http://purl.obolibrary.org/obo/GO_0047081 GO:0047080 biolink:MolecularActivity deoxyuridine 2'-dioxygenase activity Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine. EC:1.14.11.3|KEGG_REACTION:R01879|MetaCyc:1.14.11.3-RXN|RHEA:21076 go.json 2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)|deoxyuridine 2'-hydroxylase activity|pyrimidine deoxyribonucleoside 2'-hydroxylase activity|pyrimidine-deoxynucleoside 2'-dioxygenase activity|pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity|thymidine 2'-dioxygenase activity|thymidine 2'-hydroxylase activity|thymidine 2-oxoglutarate dioxygenase activity|thymidine dioxygenase activity http://purl.obolibrary.org/obo/GO_0047080 GO:0072039 biolink:BiologicalProcess regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. go.json regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis|regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072039 GO:0072038 biolink:BiologicalProcess mesenchymal stem cell maintenance involved in nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072038 GO:0072037 biolink:BiologicalProcess mesenchymal stem cell differentiation involved in nephron morphogenesis The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072037 GO:0072036 biolink:BiologicalProcess mesenchymal to epithelial transition involved in renal vesicle formation A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle. go.json http://purl.obolibrary.org/obo/GO_0072036 GO:0072035 biolink:BiologicalProcess pre-tubular aggregate formation The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney. go.json mesenchymal cell condensation involved in renal vesicle formation|nephron epithelium formation http://purl.obolibrary.org/obo/GO_0072035 GO:0047089 biolink:MolecularActivity dihydrochelirubine 12-monooxygenase activity Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+. EC:1.14.14.101|KEGG_REACTION:R04708|MetaCyc:1.14.13.57-RXN|RHEA:10156 go.json dihydrochelirubine 12-hydroxylase activity|dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating) http://purl.obolibrary.org/obo/GO_0047089 GO:0072023 biolink:BiologicalProcess thick ascending limb development The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule. go.json TAL development http://purl.obolibrary.org/obo/GO_0072023 GO:0047088 biolink:MolecularActivity dihydrosanguinarine 10-monooxygenase activity Catalysis of the reaction: dihydrosanguinarine + H+ + NADPH + O2 = 10-hydroxydihydrosanguinarine + H2O + NADP+. EC:1.14.14.100|KEGG_REACTION:R04702|MetaCyc:1.14.13.56-RXN|RHEA:10528 go.json dihydrosanguinarine 10-hydroxylase activity|dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating) http://purl.obolibrary.org/obo/GO_0047088 GO:0072022 biolink:BiologicalProcess descending thin limb development The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle. go.json http://purl.obolibrary.org/obo/GO_0072022 GO:0047087 biolink:MolecularActivity protopine 6-monooxygenase activity Catalysis of the reaction: H+ + NADPH + O2 + protopine = 6-hydroxyprotopine + H2O + NADP+. EC:1.14.14.98|KEGG_REACTION:R04699|MetaCyc:1.14.13.55-RXN|RHEA:22644 go.json protopine 6-hydroxylase activity|protopine,NADPH:oxygen oxidoreductase (6-hydroxylating) http://purl.obolibrary.org/obo/GO_0047087 GO:0072021 biolink:BiologicalProcess ascending thin limb development The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent. go.json http://purl.obolibrary.org/obo/GO_0072021 GO:0047086 biolink:MolecularActivity ketosteroid monooxygenase activity Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. EC:1.14.13.54|MetaCyc:1.14.13.54-RXN go.json 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)|androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)|ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)|progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)|steroid-ketone monooxygenase activity http://purl.obolibrary.org/obo/GO_0047086 GO:0072020 biolink:BiologicalProcess proximal straight tubule development The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule. go.json S3 development http://purl.obolibrary.org/obo/GO_0072020 GO:0047085 biolink:MolecularActivity hydroxyphenylacetonitrile 2-monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+. KEGG_REACTION:R02708|MetaCyc:1.14.13.42-RXN|RHEA:50732 go.json 4-hydroxyphenylacetonitrile hydroxylase activity|4-hydroxyphenylacetonitrile monooxygenase activity|4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating) http://purl.obolibrary.org/obo/GO_0047085 GO:0047084 biolink:MolecularActivity methyltetrahydroprotoberberine 14-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine. EC:1.14.14.97|MetaCyc:1.14.13.37-RXN|RHEA:23684 go.json (S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)|(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity|(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity|methyltetrahydroprotoberberine 14-hydroxylase activity http://purl.obolibrary.org/obo/GO_0047084 GO:0047083 biolink:MolecularActivity 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate. EC:1.14.14.96|MetaCyc:1.14.13.36-RXN|RHEA:16265 go.json 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity|coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity|trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating) http://purl.obolibrary.org/obo/GO_0047083 GO:0047082 biolink:MolecularActivity 3,9-dihydroxypterocarpan 6a-monooxygenase activity Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol. EC:1.14.14.93|KEGG_REACTION:R03452|MetaCyc:RXN-4505|RHEA:15321 go.json (6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)|3,9-dihydroxypterocarpan 6a-hydroxylase activity|3,9-dihydroxypterocarpan 6alpha-monooxygenase http://purl.obolibrary.org/obo/GO_0047082 GO:0047092 biolink:MolecularActivity 27-hydroxycholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. EC:1.14.14.29|MetaCyc:RXN-7980|RHEA:24308 go.json 27-hydroxycholesterol 7-alpha-hydroxylase activity|27-hydroxycholesterol 7a-hydroxylase activity|27-hydroxycholesterol 7alpha-hydroxylase activity|27-hydroxycholesterol 7alpha-monooxygenase activity|27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) http://purl.obolibrary.org/obo/GO_0047092 GO:0047091 biolink:MolecularActivity L-lysine 6-monooxygenase (NADPH) activity Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+. EC:1.14.13.59|KEGG_REACTION:R00448|MetaCyc:1.14.13.59-RXN|RHEA:23228 go.json L-lysine 6-monooxygenase activity|L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)|lysine N(6)-hydroxylase activity|lysine N6-hydroxylase activity http://purl.obolibrary.org/obo/GO_0047091 GO:0047090 biolink:MolecularActivity benzoyl-CoA 3-monooxygenase activity Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+. EC:1.14.13.58|KEGG_REACTION:R02449|MetaCyc:1.14.13.58-RXN|RHEA:23216 go.json benzoyl-CoA 3-hydroxylase activity|benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating) http://purl.obolibrary.org/obo/GO_0047090 GO:0072029 biolink:BiologicalProcess long nephron development The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla. go.json juxtamedullary nephron development http://purl.obolibrary.org/obo/GO_0072029 GO:0072028 biolink:BiologicalProcess nephron morphogenesis The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072028 GO:0072027 biolink:BiologicalProcess connecting tubule development The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct. go.json connecting duct development http://purl.obolibrary.org/obo/GO_0072027 GO:0072026 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072026 GO:0072025 biolink:BiologicalProcess distal convoluted tubule development The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. go.json http://purl.obolibrary.org/obo/GO_0072025 GO:0072024 biolink:BiologicalProcess macula densa development The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072024 GO:0106034 biolink:BiologicalProcess protein maturation by [2Fe-2S] cluster transfer The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. go.json http://purl.obolibrary.org/obo/GO_0106034 GO:0106033 biolink:CellularComponent spine synapse A type of synapse occurring between an axon and a dendritic spine. go.json dendritic spine synapse http://purl.obolibrary.org/obo/GO_0106033 GO:0106032 biolink:MolecularActivity snRNA pseudouridine synthase activity Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. go.json http://purl.obolibrary.org/obo/GO_0106032 GO:0106038 biolink:BiologicalProcess obsolete vesicle assembly OBSOLETE. A process carried out at the cellular level, which results in the arrangement of constituent parts of a vesicle. Vesicle assembly begins with membrane bending (GO:0097753) and ends with fusion of the vesicle after vesicle scission (GO:0099050). go.json vesicle biosynthesis|vesicle formation True http://purl.obolibrary.org/obo/GO_0106038 GO:0106037 biolink:CellularComponent apicomedial cortex The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell. go.json medioapical cortex http://purl.obolibrary.org/obo/GO_0106037 GO:0106036 biolink:BiologicalProcess assembly of apicomedial cortex actomyosin A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin. go.json http://purl.obolibrary.org/obo/GO_0106036 GO:0106035 biolink:BiologicalProcess protein maturation by [4Fe-4S] cluster transfer The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. go.json http://purl.obolibrary.org/obo/GO_0106035 GO:0106039 biolink:BiologicalProcess obsolete vesicle fusion involved in vesicle assembly OBSOLETE. A process carried out at the cellular level, which is the final step in vesicle assembly. Vesicle fusion occurs when a newly assembled vesicle closes up, following vesicle vesicle scission (GO:0099050). go.json True http://purl.obolibrary.org/obo/GO_0106039 GO:0106041 biolink:BiologicalProcess positive regulation of GABA-A receptor activity Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity. go.json http://purl.obolibrary.org/obo/GO_0106041 gocheck_do_not_annotate GO:0106040 biolink:BiologicalProcess regulation of GABA-A receptor activity Any process that modulates the frequency, rate or extent of GABA-A receptor activity. go.json http://purl.obolibrary.org/obo/GO_0106040 gocheck_do_not_annotate GO:0106045 biolink:BiologicalProcess guanine deglycation, methylglyoxal removal The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine. go.json http://purl.obolibrary.org/obo/GO_0106045 GO:0106044 biolink:BiologicalProcess guanine deglycation The removal of a sugar or dicarbonyl from a glycated guanine. go.json http://purl.obolibrary.org/obo/GO_0106044 GO:0106042 biolink:BiologicalProcess negative regulation of GABA-A receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity. go.json http://purl.obolibrary.org/obo/GO_0106042 gocheck_do_not_annotate GO:0106049 biolink:BiologicalProcess regulation of cellular response to osmotic stress Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress. go.json http://purl.obolibrary.org/obo/GO_0106049 GO:0106048 biolink:BiologicalProcess spermidine deacetylation The modification of acetylspermadine by the removal of acetyl groups. go.json N8-acetylspermidine deacetylation http://purl.obolibrary.org/obo/GO_0106048 GO:0106047 biolink:BiologicalProcess polyamine deacetylation The modification of acetylpolyamine by the removal of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0106047 GO:0106046 biolink:BiologicalProcess guanine deglycation, glyoxal removal The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine. go.json http://purl.obolibrary.org/obo/GO_0106046 GO:0106050 biolink:MolecularActivity tRNA 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide. go.json http://purl.obolibrary.org/obo/GO_0106050 GO:0106056 biolink:BiologicalProcess regulation of calcineurin-mediated signaling Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling. go.json http://purl.obolibrary.org/obo/GO_0106056 GO:0106055 biolink:CellularComponent mannosyl-oligosaccharide 1,2-alpha-mannosidase complex A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. go.json http://purl.obolibrary.org/obo/GO_0106055 GO:0106054 biolink:MolecularActivity tRNA-uracil-34 sulfurtransferase activity Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. go.json tRNA U34 2-thiouridylase|tRNA U34 thiol-transferase activity|tRNA-specific 2-thiouridylase http://purl.obolibrary.org/obo/GO_0106054 GO:0106059 biolink:MolecularActivity tRNA (cytidine(56)-2'-O)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA. EC:2.1.1.206|MetaCyc:RXN-11869|RHEA:42968 go.json tRNA (cytidine 56-2'-O)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0106059 GO:0106058 biolink:BiologicalProcess positive regulation of calcineurin-mediated signaling Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling. go.json http://purl.obolibrary.org/obo/GO_0106058 GO:0106057 biolink:BiologicalProcess negative regulation of calcineurin-mediated signaling Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling. go.json http://purl.obolibrary.org/obo/GO_0106057 GO:0106063 biolink:MolecularActivity G protein-coupled folate receptor activity Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. go.json G-protein coupled folate receptor activity|G-protein coupled folic acid receptor activity http://purl.obolibrary.org/obo/GO_0106063 GO:0106062 biolink:BiologicalProcess positive regulation of exit from meiosis Any process that activates or increases the frequency, rate or extent of exit from meiosis. go.json http://purl.obolibrary.org/obo/GO_0106062 GO:0106061 biolink:BiologicalProcess negative regulation of exit from meiosis Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis. go.json http://purl.obolibrary.org/obo/GO_0106061 GO:0106060 biolink:BiologicalProcess regulation of exit from meiosis Any process that modulates the frequency, rate or extent of exit from mitosis. go.json http://purl.obolibrary.org/obo/GO_0106060 GO:0106064 biolink:BiologicalProcess regulation of cobalamin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. go.json http://purl.obolibrary.org/obo/GO_0106064 GO:0106069 biolink:CellularComponent synapsis initiation complex A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. go.json http://purl.obolibrary.org/obo/GO_0106069 GO:0106068 biolink:CellularComponent SUMO ligase complex A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. go.json SUMO transferase complex|SUMO-protein ligase complex|Sumoylation complex http://purl.obolibrary.org/obo/GO_0106068 GO:0106070 biolink:BiologicalProcess regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. go.json regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0106070 GO:0106074 biolink:BiologicalProcess aminoacyl-tRNA metabolism involved in translational fidelity Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation. go.json aminoacyl-tRNA correction|aminoacyl-tRNA editin|aminoacyl-tRNA proofreading http://purl.obolibrary.org/obo/GO_0106074 GO:0106073 biolink:MolecularActivity dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. EC:2.4.1.256|RHEA:29543 go.json http://purl.obolibrary.org/obo/GO_0106073 GO:0106072 biolink:BiologicalProcess negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. go.json negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0106072 GO:0106071 biolink:BiologicalProcess positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. go.json positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0106071 GO:0106001 biolink:BiologicalProcess intestinal hexose absorption Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine. go.json http://purl.obolibrary.org/obo/GO_0106001 GO:0106005 biolink:BiologicalProcess RNA 5'-cap (guanine-N7)-methylation The process whereby a guanine in 5-cap is methylated at the N7 position of guanine. go.json http://purl.obolibrary.org/obo/GO_0106005 GO:0106004 biolink:BiologicalProcess tRNA (guanine-N7)-methylation The process whereby a guanine in a tRNA is methylated at the N7 position of guanine. go.json http://purl.obolibrary.org/obo/GO_0106004 GO:0106003 biolink:CellularComponent amyloid-beta complex Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. go.json ADDL complex|Abeta complex|Abeta-derived diffusible ligand complex|amyloid beta complex|amyloid beta dimer|amyloid beta heterodimer|amyloid beta heterooligomer|amyloid beta heterotrimer|amyloid beta homodimer|amyloid beta homooligomer|amyloid beta homotrimer|amyloid beta oligomer|amyloid beta trimer|amyloid-beta protein 40 complex|amyloid-beta protein 40/42 complex|amyloid-beta protein 42 complex|beta amyloid complex|beta-amyloid complex|betaA complex|heterodimer of amyloid beta protein|heterooligomer of amyloid beta protein|heterotrimer of amyloid beta protein|homodimer of amyloid beta protein|homooligomer of amyloid beta protein|homotrimer of amyloid beta protein http://purl.obolibrary.org/obo/GO_0106003 GO:0106002 biolink:CellularComponent mCRD-mediated mRNA stability complex A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. go.json mCRD-poly(A)-bridging complex|major coding region determinant of instability-mediated mRNA stability complex|major coding region instability determinant-mediated mRNA stability complex|major coding region instability determinant-poly(A)-bridging complex|major coding-region determinant of instability - poly(A) tail-bridging complex http://purl.obolibrary.org/obo/GO_0106002 GO:0106009 biolink:MolecularActivity (4S)-4-hydroxy-2-oxoglutarate aldolase activity Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. EC:4.1.3.42|RHEA:35639 go.json http://purl.obolibrary.org/obo/GO_0106009 GO:0023070 biolink:BiologicalProcess obsolete signal transmission via air OBSOLETE. The process in which a signal is conveyed via the air. go.json signal transmission via air True http://purl.obolibrary.org/obo/GO_0023070 GO:0106008 biolink:MolecularActivity 2-oxoglutaramate amidase activity Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3. EC:3.5.1.111|RHEA:32963 go.json http://purl.obolibrary.org/obo/GO_0106008 GO:0106007 biolink:BiologicalProcess microtubule anchoring at cell cortex of cell tip Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex. go.json http://purl.obolibrary.org/obo/GO_0106007 GO:0106006 biolink:MolecularActivity cytoskeletal protein-membrane anchor activity The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location. go.json BAR domain adaptor|F-BAR domain adaptor|cytoskeletal protein membrane adaptor|cytoskeletal protein membrane anchor activity|cytoskeletal protein membrane tether activity|cytoskeletal protein to membrane recruiting activity|cytoskeletal protein-membrane adaptor activity|membrane-cytoskeletal protein anchor activity|membrane-cytoskeletal protein tether activity|microtubule cortical anchor activity http://purl.obolibrary.org/obo/GO_0106006 GO:0106012 biolink:BiologicalProcess positive regulation of protein localization to medial cortex Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex. go.json http://purl.obolibrary.org/obo/GO_0106012 GO:0023067 biolink:BiologicalProcess obsolete signal transmission via lymphatic system OBSOLETE. The process in which a signal is conveyed via the lymphatic system. go.json signal transmission via lymphatic system True http://purl.obolibrary.org/obo/GO_0023067 GO:0023066 biolink:BiologicalProcess obsolete signal transmission via vascular system OBSOLETE. The process in which a signal is conveyed via the vascular system. go.json signal transmission via vascular system True http://purl.obolibrary.org/obo/GO_0023066 GO:0106011 biolink:BiologicalProcess regulation of protein localization to medial cortex Any process that regulates the localization of a protein to the medial cortex. go.json http://purl.obolibrary.org/obo/GO_0106011 GO:0023069 biolink:BiologicalProcess obsolete signal transmission via xylem OBSOLETE. The process in which a signal is conveyed via the xylem. go.json signal transmission via xylem True http://purl.obolibrary.org/obo/GO_0023069 GO:0023068 biolink:BiologicalProcess obsolete signal transmission via phloem OBSOLETE. The process in which a signal is conveyed via the phloem. go.json signal transmission via phloem True http://purl.obolibrary.org/obo/GO_0023068 GO:0106016 biolink:BiologicalProcess positive regulation of inflammatory response to wounding Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding. go.json http://purl.obolibrary.org/obo/GO_0106016 GO:0106015 biolink:BiologicalProcess negative regulation of inflammatory response to wounding Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. go.json http://purl.obolibrary.org/obo/GO_0106015 GO:0106014 biolink:BiologicalProcess regulation of inflammatory response to wounding Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. go.json http://purl.obolibrary.org/obo/GO_0106014 GO:0106013 biolink:BiologicalProcess negative regulation of protein localization to cell cortex of cell tip Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip. go.json http://purl.obolibrary.org/obo/GO_0106013 GO:0106019 biolink:MolecularActivity phosphatidylinositol-4,5-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0106019 GO:0023061 biolink:BiologicalProcess signal release The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. go.json signal secretion http://purl.obolibrary.org/obo/GO_0023061 GO:0106018 biolink:MolecularActivity phosphatidylinositol-3,5-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0106018 GO:0023060 biolink:BiologicalProcess obsolete signal transmission OBSOLETE. The process in which a signal is released and/or conveyed from one location to another. go.json signal transmission True http://purl.obolibrary.org/obo/GO_0023060 GO:0106017 biolink:MolecularActivity phosphatidylinositol-3,4-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0106017 GO:0023062 biolink:BiologicalProcess obsolete signal transmission via transcytosis OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. go.json signal transmission via transcytosis True http://purl.obolibrary.org/obo/GO_0023062 GO:0023065 biolink:BiologicalProcess obsolete signal transmission via blood OBSOLETE. The process in which a signal is conveyed via blood. go.json signal transmission via blood True http://purl.obolibrary.org/obo/GO_0023065 GO:0023056 biolink:BiologicalProcess positive regulation of signaling Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. go.json positive regulation of signaling process|positive regulation of signalling process http://purl.obolibrary.org/obo/GO_0023056 GO:0047001 biolink:MolecularActivity 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate. EC:1.1.1.127|MetaCyc:1.1.1.127-RXN|RHEA:24232 go.json 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity|2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity|2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity|2-keto-3-deoxygluconate 5-dehydrogenase activity|2-keto-3-deoxygluconate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047001 GO:0106023 biolink:BiologicalProcess regulation of pupariation Any process that modulates the onset of pupariation. go.json http://purl.obolibrary.org/obo/GO_0106023 GO:0047000 biolink:MolecularActivity 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H+ + NADPH. EC:1.1.1.126|KEGG_REACTION:R01543|MetaCyc:RXN-13040|RHEA:15109 go.json 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity|2-keto-3-deoxy-D-gluconate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047000 GO:0106022 biolink:BiologicalProcess positive regulation of vesicle docking Any process that activates or increases the frequency, rate or extent of vesicle docking. go.json positive regulation of vesicle to membrane docking http://purl.obolibrary.org/obo/GO_0106022 GO:0023055 biolink:BiologicalProcess obsolete signal initiation by peptide hormone OBSOLETE. The process in which a signal is initiated by a peptide hormone. go.json signal initiation by peptide hormone True http://purl.obolibrary.org/obo/GO_0023055 GO:0023058 biolink:BiologicalProcess adaptation of signaling pathway The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. go.json adaptation of signalling pathway http://purl.obolibrary.org/obo/GO_0023058 GO:0106021 biolink:BiologicalProcess negative regulation of vesicle docking Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking. go.json negative regulation of vesicle to membrane docking http://purl.obolibrary.org/obo/GO_0106021 GO:0106020 biolink:BiologicalProcess regulation of vesicle docking Any process that modulates the frequency, rate or extent of vesicle docking. go.json regulation of vesicle to membrane docking http://purl.obolibrary.org/obo/GO_0106020 GO:0023057 biolink:BiologicalProcess negative regulation of signaling Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. go.json negative regulation of signaling process|negative regulation of signalling process http://purl.obolibrary.org/obo/GO_0023057 GO:0106027 biolink:BiologicalProcess neuron projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. go.json http://purl.obolibrary.org/obo/GO_0106027 GO:0023059 biolink:BiologicalProcess positive adaptation of signaling pathway The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. go.json positive adaptation of signalling pathway http://purl.obolibrary.org/obo/GO_0023059 GO:0106026 biolink:MolecularActivity Gly-tRNA(Ala) hydrolase activity Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala). go.json http://purl.obolibrary.org/obo/GO_0106026 GO:0106025 biolink:BiologicalProcess positive regulation of pupariation Any process that activates or increases the frequency, rate or extent of onset of pupariation. go.json http://purl.obolibrary.org/obo/GO_0106025 GO:0106024 biolink:BiologicalProcess negative regulation of pupariation Any process that stops, prevents or reduces the rate of onset of pupariation. go.json http://purl.obolibrary.org/obo/GO_0106024 GO:0047009 biolink:MolecularActivity 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione. EC:1.1.1.152|MetaCyc:1.1.1.152-RXN|RHEA:10356 go.json 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity|3alpha-hydroxy-5beta-steroid dehydrogenase activity|3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity|etiocholanolone 3-alpha-dehydrogenase activity|etiocholanolone 3alpha-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047009 GO:0047008 biolink:MolecularActivity pregnan-21-ol dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al. EC:1.1.1.151|KEGG_REACTION:R03044|MetaCyc:1.1.1.151-RXN|RHEA:23712 go.json 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity|21-hydroxy steroid dehydrogenase activity|21-hydroxysteroid dehydrogenase (NADP+) activity|21-hydroxysteroid:NADP+ 21-oxidoreductase activity|NADP-21-hydroxysteroid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047008 GO:0106029 biolink:MolecularActivity tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. EC:5.4.99.12|EC:5.4.99.25|EC:5.4.99.26|EC:5.4.99.27|EC:5.4.99.28|EC:5.4.99.42|EC:5.4.99.44|EC:5.4.99.45|MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN|RHEA:22376 go.json Mitochondrial tRNA pseudouridine(27/28) synthase|tRNA pseudouridine(13) synthase|tRNA pseudouridine(31) synthase|tRNA pseudouridine(32) synthase|tRNA pseudouridine(38-40) synthase|tRNA pseudouridine(38/39) synthase|tRNA pseudouridine(55) synthase|tRNA pseudouridine(65) synthase|tRNA pseudouridylate synthase I activity|tRNA-pseudouridine synthase I activity|tRNA-pseudouridine synthase activity|tRNA-uridine isomerase activity|tRNA-uridine uracilmutase activity|transfer RNA pseudouridine synthetase activity|transfer ribonucleate pseudouridine synthetase activity http://purl.obolibrary.org/obo/GO_0106029 GO:0023050 biolink:BiologicalProcess obsolete consequence of signal transmission OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state. go.json consequence of signal transmission|signal termination True http://purl.obolibrary.org/obo/GO_0023050 GO:0047007 biolink:MolecularActivity pregnan-21-ol dehydrogenase (NAD+) activity Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al. EC:1.1.1.150|KEGG_REACTION:R03043|MetaCyc:1.1.1.150-RXN|RHEA:11448 go.json 21-hydroxysteroid dehydrogenase (NAD+) activity|21-hydroxysteroid:NAD+ 21-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047007 GO:0106028 biolink:BiologicalProcess neuron projection retraction The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. go.json neuron projection disassembly http://purl.obolibrary.org/obo/GO_0106028 GO:0047006 biolink:MolecularActivity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. EC:1.1.1.149|MetaCyc:1.1.1.149-RXN go.json 20alpha-HSD|20alpha-HSDH|20alpha-hydroxy steroid dehydrogenase activity|20alpha-hydroxysteroid dehydrogenase|20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047006 GO:0047005 biolink:MolecularActivity 16-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid. EC:1.1.1.147|MetaCyc:1.1.1.147-RXN go.json 16alpha-hydroxy steroid dehydrogenase activity|16alpha-hydroxysteroid dehydrogenase activity|16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047005 GO:0023052 biolink:BiologicalProcess signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. go.json biological signaling|signaling process|signalling|signalling process|single organism signaling http://purl.obolibrary.org/obo/GO_0023052 goslim_agr|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_pombe|goslim_yeast|prokaryote_subset GO:0047004 biolink:MolecularActivity UDP-N-acetylglucosamine 6-dehydrogenase activity Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-alpha-D-glucosamine = 3 H+ + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate. EC:1.1.1.136|KEGG_REACTION:R00421|MetaCyc:1.1.1.136-RXN|RHEA:13325 go.json UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity|UDP-GLcNAc dehydrogenase activity|UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity|UDPacetylglucosamine dehydrogenase activity|uridine diphosphoacetylglucosamine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047004 GO:0023051 biolink:BiologicalProcess regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process. go.json regulation of signaling process|regulation of signalling process http://purl.obolibrary.org/obo/GO_0023051 GO:0047003 biolink:MolecularActivity dTDP-6-deoxy-L-talose 4-dehydrogenase activity Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH. EC:1.1.1.134|KEGG_REACTION:R02776|MetaCyc:1.1.1.134-RXN|RHEA:23648 go.json TDP-6-deoxy-L-talose dehydrogenase activity|dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)|dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity|thymidine diphospho-6-deoxy-L-talose dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047003 GO:0023054 biolink:BiologicalProcess obsolete signal initiation by stretch effect OBSOLETE. The process in which a stretch signal causes activation of a receptor. go.json signal initiation by stretch effect True http://purl.obolibrary.org/obo/GO_0023054 GO:0047002 biolink:MolecularActivity L-arabinitol 2-dehydrogenase activity Catalysis of the reaction: L-arabinitol + NAD+ = L-ribulose + H+ + NADH. EC:1.1.1.13|KEGG_REACTION:R02441|MetaCyc:1.1.1.13-RXN|RHEA:21356 go.json L-arabinitol 2-dehydrogenase (ribulose forming) activity http://purl.obolibrary.org/obo/GO_0047002 GO:0023053 biolink:BiologicalProcess obsolete signal initiation by mechanical effect OBSOLETE. The process in which a mechanical signal causes activation of a receptor. go.json signal initiation by mechanical effect True http://purl.obolibrary.org/obo/GO_0023053 GO:0106030 biolink:BiologicalProcess neuron projection fasciculation The collection of neuronal projections into a bundle of rods, known as a fascicle. go.json http://purl.obolibrary.org/obo/GO_0106030 OIO:shorthand biolink:OntologyClass shorthand go.json http://www.geneontology.org/formats/oboInOwl#shorthand GO:0072177 biolink:BiologicalProcess mesonephric duct development The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros. go.json Wolffian duct development http://purl.obolibrary.org/obo/GO_0072177 GO:0072176 biolink:BiologicalProcess nephric duct development The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. go.json http://purl.obolibrary.org/obo/GO_0072176 GO:0072175 biolink:BiologicalProcess epithelial tube formation The developmental process pertaining to the initial formation of an epithelial tube. go.json http://purl.obolibrary.org/obo/GO_0072175 GO:0072174 biolink:BiologicalProcess metanephric tubule formation The developmental process pertaining to the initial formation of a metanephric tubule. go.json http://purl.obolibrary.org/obo/GO_0072174 GO:0072173 biolink:BiologicalProcess metanephric tubule morphogenesis The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072173 GO:0072172 biolink:BiologicalProcess mesonephric tubule formation The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0072172 GO:0072171 biolink:BiologicalProcess mesonephric tubule morphogenesis The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0072171 GO:0072170 biolink:BiologicalProcess metanephric tubule development The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072170 GO:0072179 biolink:BiologicalProcess nephric duct formation The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney. go.json http://purl.obolibrary.org/obo/GO_0072179 GO:0072178 biolink:BiologicalProcess nephric duct morphogenesis The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. go.json http://purl.obolibrary.org/obo/GO_0072178 GO:0072166 biolink:BiologicalProcess posterior mesonephric tubule development The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0072166 GO:0072165 biolink:BiologicalProcess anterior mesonephric tubule development The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0072165 GO:0072164 biolink:BiologicalProcess mesonephric tubule development The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros. go.json http://purl.obolibrary.org/obo/GO_0072164 GO:0072163 biolink:BiologicalProcess mesonephric epithelium development The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. go.json http://purl.obolibrary.org/obo/GO_0072163 GO:0072162 biolink:BiologicalProcess metanephric mesenchymal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072162 GO:0072161 biolink:BiologicalProcess mesenchymal cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072161 GO:0072160 biolink:BiologicalProcess nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072160 GO:0072169 biolink:BiologicalProcess specification of posterior mesonephric tubule identity The process in which the tubules of the posterior mesonephros acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0072169 GO:0072168 biolink:BiologicalProcess specification of anterior mesonephric tubule identity The process in which the tubules of the anterior mesonephros acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0072168 GO:0072167 biolink:BiologicalProcess specification of mesonephric tubule identity The process in which the tubules of the mesonephros acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0072167 GO:0072199 biolink:BiologicalProcess regulation of mesenchymal cell proliferation involved in ureter development Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json regulation of ureter mesenchymal cell proliferation|regulation of ureteral mesenchymal cell proliferation http://purl.obolibrary.org/obo/GO_0072199 GO:0072198 biolink:BiologicalProcess mesenchymal cell proliferation involved in ureter development The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development. go.json ureter mesenchymal cell proliferation|ureteral mesenchymal cell proliferation http://purl.obolibrary.org/obo/GO_0072198 GO:0072197 biolink:BiologicalProcess ureter morphogenesis The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder. go.json http://purl.obolibrary.org/obo/GO_0072197 GO:0072196 biolink:BiologicalProcess proximal/distal pattern formation involved in pronephric nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros. go.json pronephros proximal/distal pattern formation http://purl.obolibrary.org/obo/GO_0072196 GO:0072195 biolink:BiologicalProcess kidney smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney. go.json http://purl.obolibrary.org/obo/GO_0072195 GO:0072194 biolink:BiologicalProcess kidney smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072194 GO:0072193 biolink:BiologicalProcess ureter smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter. go.json http://purl.obolibrary.org/obo/GO_0072193 GO:0072192 biolink:BiologicalProcess ureter epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter. go.json http://purl.obolibrary.org/obo/GO_0072192 GO:0072191 biolink:BiologicalProcess ureter smooth muscle development The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072191 GO:0072190 biolink:BiologicalProcess ureter urothelium development The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter. go.json ureter epithelium development http://purl.obolibrary.org/obo/GO_0072190 GO:0072188 biolink:BiologicalProcess metanephric cap specification The process in which the metanephric cap acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072188 GO:0072187 biolink:BiologicalProcess metanephric cap formation The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. go.json http://purl.obolibrary.org/obo/GO_0072187 GO:0072186 biolink:BiologicalProcess metanephric cap morphogenesis The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. go.json http://purl.obolibrary.org/obo/GO_0072186 GO:0072185 biolink:BiologicalProcess metanephric cap development The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. go.json http://purl.obolibrary.org/obo/GO_0072185 GO:0072184 biolink:BiologicalProcess renal vesicle progenitor cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing. go.json http://purl.obolibrary.org/obo/GO_0072184 GO:0072183 biolink:BiologicalProcess negative regulation of nephron tubule epithelial cell differentiation Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0072183 GO:0072182 biolink:BiologicalProcess regulation of nephron tubule epithelial cell differentiation Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0072182 GO:0072181 biolink:BiologicalProcess mesonephric duct formation The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros. go.json Wolffian duct formation http://purl.obolibrary.org/obo/GO_0072181 GO:0072180 biolink:BiologicalProcess mesonephric duct morphogenesis The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros. go.json Wolffian duct morphogenesis http://purl.obolibrary.org/obo/GO_0072180 GO:0072189 biolink:BiologicalProcess ureter development The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. go.json http://purl.obolibrary.org/obo/GO_0072189 GO:0047133 biolink:MolecularActivity dimethylamine dehydrogenase activity Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine. EC:1.5.8.1|MetaCyc:1.5.8.1-RXN|RHEA:10204|UM-BBD_reactionID:r1380 go.json DMADh activity|dimethylamine:electron-transferring flavoprotein oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047133 GO:0047132 biolink:MolecularActivity dihydrobenzophenanthridine oxidase activity Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine. EC:1.5.3.12|MetaCyc:1.5.3.12-RXN|RHEA:16621 go.json dihydrobenzophenanthridine:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047132 GO:0047131 biolink:MolecularActivity saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH. EC:1.5.1.9|KEGG_REACTION:R02313|MetaCyc:1.5.1.9-RXN|RHEA:24520|Reactome:R-HSA-70940 go.json 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)|N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)|NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)|aminoadipic semialdehyde synthase activity|dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)|saccharopin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047131 GO:0047130 biolink:MolecularActivity saccharopine dehydrogenase (NADP+, L-lysine-forming) activity Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH. EC:1.5.1.8|KEGG_REACTION:R00716|MetaCyc:1.5.1.8-RXN|RHEA:19373|Reactome:R-HSA-70938 go.json 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|L-lysine-alpha-ketoglutarate reductase activity|N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)|saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047130 GO:1904959 biolink:BiologicalProcess regulation of cytochrome-c oxidase activity Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity. go.json regulation of NADH cytochrome c oxidase|regulation of aa3-type cytochrome c oxidase|regulation of ba3-type cytochrome c oxidase|regulation of caa3-type cytochrome c oxidase|regulation of cbb3-type cytochrome c oxidase|regulation of complex IV (mitochondrial electron transport) activity|regulation of cytochrome a3 activity|regulation of cytochrome aa3 activity|regulation of cytochrome c oxidase activity|regulation of cytochrome oxidase activity|regulation of ferrocytochrome c oxidase|regulation of ferrocytochrome-c:oxygen oxidoreductase|regulation of indophenol oxidase|regulation of indophenolase|regulation of warburg's respiratory enzyme activity http://purl.obolibrary.org/obo/GO_1904959 gocheck_do_not_annotate GO:1904958 biolink:BiologicalProcess positive regulation of midbrain dopaminergic neuron differentiation Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation. go.json activation of DA neurogenesis from midbrain floor plate|activation of mDA neuron differentiation|activation of midbrain DA neurogenesis|activation of midbrain dopaminergic neuron differentiation|activation of midbrain dopaminergic neuron production|positive regulation of DA neurogenesis from midbrain floor plate|positive regulation of mDA neuron differentiation|positive regulation of midbrain DA neurogenesis|positive regulation of midbrain dopaminergic neuron production|up regulation of DA neurogenesis from midbrain floor plate|up regulation of mDA neuron differentiation|up regulation of midbrain DA neurogenesis|up regulation of midbrain dopaminergic neuron differentiation|up regulation of midbrain dopaminergic neuron production|up-regulation of DA neurogenesis from midbrain floor plate|up-regulation of mDA neuron differentiation|up-regulation of midbrain DA neurogenesis|up-regulation of midbrain dopaminergic neuron differentiation|up-regulation of midbrain dopaminergic neuron production|upregulation of DA neurogenesis from midbrain floor plate|upregulation of mDA neuron differentiation|upregulation of midbrain DA neurogenesis|upregulation of midbrain dopaminergic neuron differentiation|upregulation of midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904958 GO:1904957 biolink:BiologicalProcess negative regulation of midbrain dopaminergic neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation. go.json down regulation of DA neurogenesis from midbrain floor plate|down regulation of mDA neuron differentiation|down regulation of midbrain DA neurogenesis|down regulation of midbrain dopaminergic neuron differentiation|down regulation of midbrain dopaminergic neuron production|down-regulation of DA neurogenesis from midbrain floor plate|down-regulation of mDA neuron differentiation|down-regulation of midbrain DA neurogenesis|down-regulation of midbrain dopaminergic neuron differentiation|down-regulation of midbrain dopaminergic neuron production|downregulation of DA neurogenesis from midbrain floor plate|downregulation of mDA neuron differentiation|downregulation of midbrain DA neurogenesis|downregulation of midbrain dopaminergic neuron differentiation|downregulation of midbrain dopaminergic neuron production|inhibition of DA neurogenesis from midbrain floor plate|inhibition of mDA neuron differentiation|inhibition of midbrain DA neurogenesis|inhibition of midbrain dopaminergic neuron differentiation|inhibition of midbrain dopaminergic neuron production|negative regulation of DA neurogenesis from midbrain floor plate|negative regulation of mDA neuron differentiation|negative regulation of midbrain DA neurogenesis|negative regulation of midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904957 GO:1904956 biolink:BiologicalProcess regulation of midbrain dopaminergic neuron differentiation Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation. go.json regulation of DA neurogenesis from midbrain floor plate|regulation of mDA neuron differentiation|regulation of midbrain DA neurogenesis|regulation of midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904956 GO:1904955 biolink:BiologicalProcess planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation Any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation. go.json PCP pathway involved in DA neurogenesis from midbrain floor plate|PCP pathway involved in mDA neuron differentiation|PCP pathway involved in midbrain DA neurogenesis|PCP pathway involved in midbrain dopaminergic neuron differentiation|PCP pathway involved in midbrain dopaminergic neuron production|Wnt receptor signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate|Wnt receptor signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation|Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis|Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production|Wnt receptor signalling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate|Wnt receptor signalling pathway, planar cell polarity pathway involved in mDA neuron differentiation|Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis|Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production|Wnt signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate|Wnt signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation|Wnt signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis|Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production|Wnt-JNK signaling pathway involved in DA neurogenesis from midbrain floor plate|Wnt-JNK signaling pathway involved in mDA neuron differentiation|Wnt-JNK signaling pathway involved in midbrain DA neurogenesis|Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron production|Wnt-PCP signaling pathway involved in DA neurogenesis from midbrain floor plate|Wnt-PCP signaling pathway involved in mDA neuron differentiation|Wnt-PCP signaling pathway involved in midbrain DA neurogenesis|Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron production|Wnt-activated signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate|Wnt-activated signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation|Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis|Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production|non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|non-canonical Wnt signaling pathway involved in mDA neuron differentiation|non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production|non-canonical Wnt-mediated midbrain DA neuron differentiation|planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate|planar cell polarity pathway involved in mDA neuron differentiation|planar cell polarity pathway involved in midbrain DA neurogenesis|planar cell polarity pathway involved in midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904955 GO:1904954 biolink:BiologicalProcess canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. go.json Wnt receptor signaling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate|Wnt receptor signaling pathway through beta-catenin involved in mDA neuron differentiation|Wnt receptor signaling pathway through beta-catenin involved in midbrain DA neurogenesis|Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation|Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron production|Wnt receptor signaling pathway via beta-catenin involved in DA neurogenesis from midbrain floor plate|Wnt receptor signaling pathway via beta-catenin involved in mDA neuron differentiation|Wnt receptor signaling pathway via beta-catenin involved in midbrain DA neurogenesis|Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron differentiation|Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron production|Wnt receptor signalling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate|Wnt receptor signalling pathway through beta-catenin involved in mDA neuron differentiation|Wnt receptor signalling pathway through beta-catenin involved in midbrain DA neurogenesis|Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation|Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron production|canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|canonical Wnt receptor signaling pathway involved in mDA neuron differentiation|canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis|canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|canonical Wnt signaling pathway involved in mDA neuron differentiation|canonical Wnt signaling pathway involved in midbrain DA neurogenesis|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production|canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|canonical Wnt-activated signaling pathway involved in mDA neuron differentiation|canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis|canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|canonical Wnt-mediated midbrain DA neuron differentiation|frizzled-1 receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|frizzled-1 receptor signaling pathway involved in mDA neuron differentiation|frizzled-1 receptor signaling pathway involved in midbrain DA neurogenesis|frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904954 GO:0047139 biolink:MolecularActivity glutathione-homocystine transhydrogenase activity Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine. EC:1.8.4.1|MetaCyc:1.8.4.1-RXN|RHEA:11464 go.json glutathione:homocystine oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047139 GO:0047138 biolink:MolecularActivity obsolete aquacobalamin reductase activity OBSOLETE. Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+. EC:1.16.1.3|MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN go.json B(12a) reductase activity|B12a reductase activity|NADH-linked aquacobalamin reductase activity|NADH2:cob(III)alamin oxidoreductase activity|NADH:cob(III)alamin oxidoreductase activity|aquocobalamin reductase activity|cob(II)alamin:NAD+ oxidoreductase activity|vitamin B(12a) reductase activity|vitamin B12a reductase activity True http://purl.obolibrary.org/obo/GO_0047138 GO:1904953 biolink:BiologicalProcess Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. go.json Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|Wg signaling pathway involved in mDA neuron differentiation|Wg signaling pathway involved in midbrain DA neurogenesis|Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|Wg signaling pathway involved in midbrain dopaminergic neuron production|Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|Wg signalling pathway involved in mDA neuron differentiation|Wg signalling pathway involved in midbrain DA neurogenesis|Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|Wg signalling pathway involved in midbrain dopaminergic neuron production|Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|Wingless signaling pathway involved in mDA neuron differentiation|Wingless signaling pathway involved in midbrain DA neurogenesis|Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|Wingless signaling pathway involved in midbrain dopaminergic neuron production|Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|Wingless signalling pathway involved in mDA neuron differentiation|Wingless signalling pathway involved in midbrain DA neurogenesis|Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|Wingless signalling pathway involved in midbrain dopaminergic neuron production|Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|Wnt receptor signaling pathway involved in mDA neuron differentiation|Wnt receptor signaling pathway involved in midbrain DA neurogenesis|Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|Wnt receptor signalling pathway involved in mDA neuron differentiation|Wnt receptor signalling pathway involved in midbrain DA neurogenesis|Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|Wnt signaling pathway involved in mDA neuron differentiation|Wnt signaling pathway involved in midbrain DA neurogenesis|Wnt signaling pathway involved in midbrain dopaminergic neuron production|Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|Wnt-activated signaling pathway involved in mDA neuron differentiation|Wnt-activated signaling pathway involved in midbrain DA neurogenesis|Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|Wnt-mediated midbrain DA neuron differentiation|frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|frizzled signaling pathway involved in mDA neuron differentiation|frizzled signaling pathway involved in midbrain DA neurogenesis|frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|frizzled signaling pathway involved in midbrain dopaminergic neuron production|frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|frizzled signalling pathway involved in mDA neuron differentiation|frizzled signalling pathway involved in midbrain DA neurogenesis|frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|frizzled signalling pathway involved in midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904953 GO:0047137 biolink:MolecularActivity N-hydroxy-2-acetamidofluorene reductase activity Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+. EC:1.7.1.12|MetaCyc:1.7.1.12-RXN go.json 2-acetamidofluorene:NAD(P)+ oxidoreductase activity|N-hydroxy-2-acetylaminofluorene reductase activity|NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity|NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047137 GO:1904952 biolink:BiologicalProcess hydroxycinnamic acid transport The directed movement of a hydroxycinnamic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1904952 GO:1904951 biolink:BiologicalProcess positive regulation of establishment of protein localization Any process that activates or increases the frequency, rate or extent of establishment of protein localization. go.json activation of establishment of protein localisation|activation of establishment of protein localization|activation of protein positioning|activation of protein recruitment|positive regulation of establishment of protein localisation|positive regulation of protein positioning|positive regulation of protein recruitment|up regulation of establishment of protein localisation|up regulation of establishment of protein localization|up regulation of protein positioning|up regulation of protein recruitment|up-regulation of establishment of protein localisation|up-regulation of establishment of protein localization|up-regulation of protein positioning|up-regulation of protein recruitment|upregulation of establishment of protein localisation|upregulation of establishment of protein localization|upregulation of protein positioning|upregulation of protein recruitment http://purl.obolibrary.org/obo/GO_1904951 GO:0047136 biolink:MolecularActivity 4-(dimethylamino)phenylazoxybenzene reductase activity Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH. EC:1.7.1.11|KEGG_REACTION:R04303|MetaCyc:1.6.6.12-RXN|RHEA:19789 go.json 4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity|N,N-dimethyl-p-aminoazobenzene oxide reductase activity|NADPH-dependent DMAB N-oxide reductase activity|NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity|NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity|dimethylaminoazobenzene N-oxide reductase activity http://purl.obolibrary.org/obo/GO_0047136 GO:1904950 biolink:BiologicalProcess negative regulation of establishment of protein localization Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. go.json down regulation of establishment of protein localisation|down regulation of establishment of protein localization|down regulation of protein positioning|down regulation of protein recruitment|down-regulation of establishment of protein localisation|down-regulation of establishment of protein localization|down-regulation of protein positioning|down-regulation of protein recruitment|downregulation of establishment of protein localisation|downregulation of establishment of protein localization|downregulation of protein positioning|downregulation of protein recruitment|inhibition of establishment of protein localisation|inhibition of establishment of protein localization|inhibition of protein positioning|inhibition of protein recruitment|negative regulation of establishment of protein localisation|negative regulation of protein positioning|negative regulation of protein recruitment http://purl.obolibrary.org/obo/GO_1904950 GO:0047135 biolink:MolecularActivity bis-gamma-glutamylcystine reductase activity Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH. EC:1.8.1.13|KEGG_REACTION:R02742|MetaCyc:1.6.4.9-RXN|RHEA:11980 go.json Bis-gamma-glutamylcystine reductase (NADPH)|NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity|NADPH:bis-gamma-glutamylcysteine oxidoreductase activity|bis-g-glutamylcystine reductase (NADPH) activity|bis-gamma-glutamylcystine reductase (NADPH) activity|gamma-glutamylcysteine:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047135 GO:0047134 biolink:MolecularActivity protein-disulfide reductase (NAD(P)) activity Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. EC:1.8.1.8|MetaCyc:1.6.4.4-RXN go.json NAD(P)H:protein-disulfide oxidoreductase activity|disulfide reductase activity|insulin-glutathione transhydrogenase activity|protein disulfide reductase (NAD(P)H) activity|protein disulfide reductase activity|protein disulphide reductase activity|protein-disulfide reductase activity|protein-disulphide reductase activity http://purl.obolibrary.org/obo/GO_0047134 GO:0047144 biolink:MolecularActivity 2-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. EC:2.3.1.52|MetaCyc:2-ACYL2.3.1.15-RXN|RHEA:14233|Reactome:R-HSA-1482533|Reactome:R-HSA-1482546|Reactome:R-HSA-1482626|Reactome:R-HSA-1482635|Reactome:R-HSA-1482646|Reactome:R-HSA-1482691 go.json 2-acylglycerophosphate acyltransferase activity|acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047144 GO:0047143 biolink:MolecularActivity chlorate reductase activity Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+. EC:1.97.1.1|KEGG_REACTION:R03575|MetaCyc:1.97.1.1-RXN|RHEA:16349|UM-BBD_reactionID:r0981 go.json chlorate reductase C|chlorite:acceptor oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047143 GO:0047142 biolink:MolecularActivity enzyme-thiol transhydrogenase (glutathione-disulfide) activity Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase. EC:1.8.4.7|MetaCyc:1.8.4.7-RXN go.json [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity|enzyme-thiol transhydrogenase (glutathione-disulphide) activity|enzyme-thiol transhydrogenase (oxidized-glutathione) activity|glutathione-dependent thiol:disulfide oxidoreductase activity|thiol:disulfide oxidoreductase activity|thiol:disulphide oxidoreductase activity|xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity|xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047142 GO:0047141 biolink:MolecularActivity glutathione-cystine transhydrogenase activity Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine. EC:1.8.4.4|MetaCyc:1.8.4.4-RXN|RHEA:12613 go.json GSH-cystine transhydrogenase|NADPH-dependent GSH-cystine transhydrogenase|glutathione:cystine oxidoreductase http://purl.obolibrary.org/obo/GO_0047141 GO:0047140 biolink:MolecularActivity glutathione-CoA-glutathione transhydrogenase activity Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione. EC:1.8.4.3|MetaCyc:1.8.4.3-RXN|RHEA:13125 go.json CoA:glutathione-disulfide oxidoreductase activity|coenzyme A:glutathione-disulfide oxidoreductase activity|coenzyme A:oxidized-glutathione oxidoreductase activity|glutathione coenzyme A-glutathione transhydrogenase activity|glutathione-coenzyme A glutathione disulfide transhydrogenase activity|glutathione:coenzyme A-glutathione transhydrogenase activity http://purl.obolibrary.org/obo/GO_0047140 GO:1904969 biolink:BiologicalProcess slow muscle cell migration The orderly movement of a slow muscle cell from one site to another. go.json slow-twitch muscle cell migration http://purl.obolibrary.org/obo/GO_1904969 GO:1904968 biolink:BiologicalProcess positive regulation of spindle attachment to meiosis I kinetochore Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation. go.json activation of attachment of spindle microtubules to kinetochore during meiosis I|activation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|activation of attachment of spindle microtubules to kinetochore involved in meiosis I|activation of monopolar attachment|activation of sister kinetochore mono-orientation|positive regulation of attachment of spindle microtubules to kinetochore during meiosis I|positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|positive regulation of attachment of spindle microtubules to kinetochore involved in meiosis I|positive regulation of monopolar attachment|positive regulation of sister kinetochore mono-orientation|up regulation of attachment of spindle microtubules to kinetochore during meiosis I|up regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|up regulation of attachment of spindle microtubules to kinetochore involved in meiosis I|up regulation of monopolar attachment|up regulation of sister kinetochore mono-orientation|up-regulation of attachment of spindle microtubules to kinetochore during meiosis I|up-regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|up-regulation of attachment of spindle microtubules to kinetochore involved in meiosis I|up-regulation of monopolar attachment|up-regulation of sister kinetochore mono-orientation|upregulation of attachment of spindle microtubules to kinetochore during meiosis I|upregulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|upregulation of attachment of spindle microtubules to kinetochore involved in meiosis I|upregulation of monopolar attachment|upregulation of sister kinetochore mono-orientation http://purl.obolibrary.org/obo/GO_1904968 GO:1904967 biolink:BiologicalProcess regulation of spindle attachment to meiosis I kinetochore Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation. go.json correction of merotelic kinetochore attachment, meiosis I|regulation of attachment of spindle microtubules to kinetochore during meiosis I|regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|regulation of attachment of spindle microtubules to kinetochore involved in meiosis I|regulation of monopolar attachment|regulation of sister kinetochore mono-orientation|repair of merotelic kinetochore attachment defect, meiosis I http://purl.obolibrary.org/obo/GO_1904967 GO:1904966 biolink:BiologicalProcess positive regulation of vitamin E biosynthetic process Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process. go.json activation of alpha-tocopherol biosynthesis|activation of alpha-tocopherol biosynthetic process|activation of tocopherol biosynthesis|activation of tocopherol biosynthetic process|activation of vitamin E anabolism|activation of vitamin E biosynthesis|activation of vitamin E biosynthetic process|activation of vitamin E formation|activation of vitamin E synthesis|positive regulation of alpha-tocopherol biosynthesis|positive regulation of alpha-tocopherol biosynthetic process|positive regulation of tocopherol biosynthesis|positive regulation of tocopherol biosynthetic process|positive regulation of vitamin E anabolism|positive regulation of vitamin E biosynthesis|positive regulation of vitamin E formation|positive regulation of vitamin E synthesis|up regulation of alpha-tocopherol biosynthesis|up regulation of alpha-tocopherol biosynthetic process|up regulation of tocopherol biosynthesis|up regulation of tocopherol biosynthetic process|up regulation of vitamin E anabolism|up regulation of vitamin E biosynthesis|up regulation of vitamin E biosynthetic process|up regulation of vitamin E formation|up regulation of vitamin E synthesis|up-regulation of alpha-tocopherol biosynthesis|up-regulation of alpha-tocopherol biosynthetic process|up-regulation of tocopherol biosynthesis|up-regulation of tocopherol biosynthetic process|up-regulation of vitamin E anabolism|up-regulation of vitamin E biosynthesis|up-regulation of vitamin E biosynthetic process|up-regulation of vitamin E formation|up-regulation of vitamin E synthesis|upregulation of alpha-tocopherol biosynthesis|upregulation of alpha-tocopherol biosynthetic process|upregulation of tocopherol biosynthesis|upregulation of tocopherol biosynthetic process|upregulation of vitamin E anabolism|upregulation of vitamin E biosynthesis|upregulation of vitamin E biosynthetic process|upregulation of vitamin E formation|upregulation of vitamin E synthesis http://purl.obolibrary.org/obo/GO_1904966 GO:1904965 biolink:BiologicalProcess regulation of vitamin E biosynthetic process Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process. go.json regulation of alpha-tocopherol biosynthesis|regulation of alpha-tocopherol biosynthetic process|regulation of tocopherol biosynthesis|regulation of tocopherol biosynthetic process|regulation of vitamin E anabolism|regulation of vitamin E biosynthesis|regulation of vitamin E formation|regulation of vitamin E synthesis http://purl.obolibrary.org/obo/GO_1904965 GO:0047149 biolink:MolecularActivity thetin-homocysteine S-methyltransferase activity Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+. EC:2.1.1.3|KEGG_REACTION:R04153|MetaCyc:2.1.1.3-RXN|RHEA:22788 go.json dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity|dimethylthetin-homocysteine methyltransferase activity|thetin-homocysteine methylpherase activity http://purl.obolibrary.org/obo/GO_0047149 GO:1904964 biolink:BiologicalProcess positive regulation of phytol biosynthetic process Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process. go.json activation of phytol anabolism|activation of phytol biosynthesis|activation of phytol biosynthetic process|activation of phytol formation|activation of phytol synthesis|positive regulation of phytol anabolism|positive regulation of phytol biosynthesis|positive regulation of phytol formation|positive regulation of phytol synthesis|up regulation of phytol anabolism|up regulation of phytol biosynthesis|up regulation of phytol biosynthetic process|up regulation of phytol formation|up regulation of phytol synthesis|up-regulation of phytol anabolism|up-regulation of phytol biosynthesis|up-regulation of phytol biosynthetic process|up-regulation of phytol formation|up-regulation of phytol synthesis|upregulation of phytol anabolism|upregulation of phytol biosynthesis|upregulation of phytol biosynthetic process|upregulation of phytol formation|upregulation of phytol synthesis http://purl.obolibrary.org/obo/GO_1904964 GO:0047148 biolink:MolecularActivity methylamine-glutamate N-methyltransferase activity Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH4. EC:2.1.1.21|KEGG_REACTION:R01586|MetaCyc:2.1.1.21-RXN|RHEA:15837 go.json N-methylglutamate synthase activity|methylamine-glutamate methyltransferase activity|methylamine:L-glutamate N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0047148 GO:1904963 biolink:BiologicalProcess regulation of phytol biosynthetic process Any process that modulates the frequency, rate or extent of phytol biosynthetic process. go.json regulation of phytol anabolism|regulation of phytol biosynthesis|regulation of phytol formation|regulation of phytol synthesis http://purl.obolibrary.org/obo/GO_1904963 GO:1904962 biolink:BiologicalProcess plastid to vacuole vesicle-mediated transport The vesicle-mediated and directed movement of substances from plastid to vacuole. go.json plastid to vacuolar carboxypeptidase Y vesicle-mediated transport http://purl.obolibrary.org/obo/GO_1904962 GO:0047147 biolink:MolecularActivity trimethylsulfonium-tetrahydrofolate N-methyltransferase activity Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+. EC:2.1.1.19|KEGG_REACTION:R02573|MetaCyc:2.1.1.19-RXN|RHEA:13693 go.json trimethylsulfonium-tetrahydrofolate methyltransferase activity|trimethylsulfonium:tetrahydrofolate N-methyltransferase activity|trimethylsulphonium-tetrahydrofolate N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0047147 GO:0047146 biolink:MolecularActivity sterigmatocystin 7-O-methyltransferase activity Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine. EC:2.1.1.110|MetaCyc:2.1.1.110-RXN|RHEA:15561 go.json O-methyltransferase II activity|S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity|S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity|sterigmatocystin 8-O-methyltransferase activity|sterigmatocystin methyltransferase activity http://purl.obolibrary.org/obo/GO_0047146 GO:1904961 biolink:BiologicalProcess quiescent center organization The process that contributes to the act of creating the structural organization of the quiescent center. This process pertains to the physical shaping of a rudimentary structure. go.json quiescent center structural organization http://purl.obolibrary.org/obo/GO_1904961 GO:1904960 biolink:BiologicalProcess positive regulation of cytochrome-c oxidase activity Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity. go.json activation of NADH cytochrome c oxidase|activation of aa3-type cytochrome c oxidase|activation of ba3-type cytochrome c oxidase|activation of caa3-type cytochrome c oxidase|activation of cbb3-type cytochrome c oxidase|activation of complex IV (mitochondrial electron transport) activity|activation of cytochrome a3 activity|activation of cytochrome aa3 activity|activation of cytochrome c oxidase activity|activation of cytochrome oxidase activity|activation of cytochrome-c oxidase activity|activation of ferrocytochrome c oxidase|activation of ferrocytochrome-c:oxygen oxidoreductase|activation of indophenol oxidase|activation of indophenolase|activation of warburg's respiratory enzyme activity|positive regulation of NADH cytochrome c oxidase|positive regulation of aa3-type cytochrome c oxidase|positive regulation of ba3-type cytochrome c oxidase|positive regulation of caa3-type cytochrome c oxidase|positive regulation of cbb3-type cytochrome c oxidase|positive regulation of complex IV (mitochondrial electron transport) activity|positive regulation of cytochrome a3 activity|positive regulation of cytochrome aa3 activity|positive regulation of cytochrome c oxidase activity|positive regulation of cytochrome oxidase activity|positive regulation of ferrocytochrome c oxidase|positive regulation of ferrocytochrome-c:oxygen oxidoreductase|positive regulation of indophenol oxidase|positive regulation of indophenolase|positive regulation of warburg's respiratory enzyme activity|up regulation of NADH cytochrome c oxidase|up regulation of aa3-type cytochrome c oxidase|up regulation of ba3-type cytochrome c oxidase|up regulation of caa3-type cytochrome c oxidase|up regulation of cbb3-type cytochrome c oxidase|up regulation of complex IV (mitochondrial electron transport) activity|up regulation of cytochrome a3 activity|up regulation of cytochrome aa3 activity|up regulation of cytochrome c oxidase activity|up regulation of cytochrome oxidase activity|up regulation of cytochrome-c oxidase activity|up regulation of ferrocytochrome c oxidase|up regulation of ferrocytochrome-c:oxygen oxidoreductase|up regulation of indophenol oxidase|up regulation of indophenolase|up regulation of warburg's respiratory enzyme activity|up-regulation of NADH cytochrome c oxidase|up-regulation of aa3-type cytochrome c oxidase|up-regulation of ba3-type cytochrome c oxidase|up-regulation of caa3-type cytochrome c oxidase|up-regulation of cbb3-type cytochrome c oxidase|up-regulation of complex IV (mitochondrial electron transport) activity|up-regulation of cytochrome a3 activity|up-regulation of cytochrome aa3 activity|up-regulation of cytochrome c oxidase activity|up-regulation of cytochrome oxidase activity|up-regulation of cytochrome-c oxidase activity|up-regulation of ferrocytochrome c oxidase|up-regulation of ferrocytochrome-c:oxygen oxidoreductase|up-regulation of indophenol oxidase|up-regulation of indophenolase|up-regulation of warburg's respiratory enzyme activity|upregulation of NADH cytochrome c oxidase|upregulation of aa3-type cytochrome c oxidase|upregulation of ba3-type cytochrome c oxidase|upregulation of caa3-type cytochrome c oxidase|upregulation of cbb3-type cytochrome c oxidase|upregulation of complex IV (mitochondrial electron transport) activity|upregulation of cytochrome a3 activity|upregulation of cytochrome aa3 activity|upregulation of cytochrome c oxidase activity|upregulation of cytochrome oxidase activity|upregulation of cytochrome-c oxidase activity|upregulation of ferrocytochrome c oxidase|upregulation of ferrocytochrome-c:oxygen oxidoreductase|upregulation of indophenol oxidase|upregulation of indophenolase|upregulation of warburg's respiratory enzyme activity http://purl.obolibrary.org/obo/GO_1904960 gocheck_do_not_annotate GO:0047145 biolink:MolecularActivity demethylsterigmatocystin 6-O-methyltransferase activity Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine. EC:2.1.1.109|MetaCyc:2.1.1.109-RXN|RHEA:11504 go.json O-methyltransferase I|S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity|demethylsterigmatocystin methyltransferase activity http://purl.obolibrary.org/obo/GO_0047145 GO:1904970 biolink:BiologicalProcess brush border assembly The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border. go.json brush border formation http://purl.obolibrary.org/obo/GO_1904970 GO:0072111 biolink:BiologicalProcess cell proliferation involved in kidney development The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney. go.json http://purl.obolibrary.org/obo/GO_0072111 GO:0047155 biolink:MolecularActivity 3-hydroxymethylcephem carbamoyltransferase activity Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem. EC:2.1.3.7|MetaCyc:2.1.3.7-RXN go.json 3'-hydroxymethylcephem-O-carbamoyltransferase activity|carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047155 GO:0047154 biolink:MolecularActivity methylmalonyl-CoA carboxytransferase activity Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA. EC:2.1.3.1|MetaCyc:2.1.3.1-RXN|RHEA:20764|UM-BBD_reactionID:r0923 go.json (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate|(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity|(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity|(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity|methylmalonyl coenzyme A carboxyltransferase activity|methylmalonyl-CoA carboxyltransferase activity|methylmalonyl-CoA transcarboxylase activity|oxalacetic transcarboxylase activity|transcarboxylase activity http://purl.obolibrary.org/obo/GO_0047154 GO:0072110 biolink:BiologicalProcess glomerular mesangial cell proliferation The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population. go.json http://purl.obolibrary.org/obo/GO_0072110 GO:0047153 biolink:MolecularActivity deoxycytidylate 5-hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate. EC:2.1.2.8|KEGG_REACTION:R01669|MetaCyc:2.1.2.8-RXN|RHEA:11280 go.json 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity|d-cytidine 5'-monophosphate hydroxymethylase activity|dCMP hydroxymethylase activity|deoxyCMP hydroxymethylase activity|deoxycytidylate hydroxymethylase activity|deoxycytidylate hydroxymethyltransferase activity|deoxycytidylic hydroxymethylase activity http://purl.obolibrary.org/obo/GO_0047153 GO:0047152 biolink:MolecularActivity methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide. EC:2.1.1.90|MetaCyc:2.1.1.90-RXN|RHEA:45204 go.json MT 1|MT1|MtaB|methanol cobalamin methyltransferase activity|methanol-corrinoid protein Co-methyltransferase|methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity|methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity|methanol:corrinoid methyltransferase activity|methyltransferase 1 http://purl.obolibrary.org/obo/GO_0047152 GO:0047151 biolink:MolecularActivity tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+. EC:2.1.1.74|KEGG_REACTION:R03704|MetaCyc:2.1.1.74-RXN|RHEA:16873 go.json 5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity|5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity|folate-dependent ribothymidyl synthase activity|methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity|methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity|tRNA (uracil(54)-C(5))-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent http://purl.obolibrary.org/obo/GO_0047151 GO:0047150 biolink:MolecularActivity betaine-homocysteine S-methyltransferase activity Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine. EC:2.1.1.5|KEGG_REACTION:R02821|MetaCyc:2.1.1.5-RXN|RHEA:22336|Reactome:R-HSA-1614654 go.json betaine-homocysteine methyltransferase activity|betaine-homocysteine transmethylase activity|trimethylammonioacetate:L-homocysteine S-methyltransferase activity http://purl.obolibrary.org/obo/GO_0047150 GO:1904979 biolink:BiologicalProcess negative regulation of endosome organization Any process that stops, prevents or reduces the frequency, rate or extent of endosome organization. go.json down regulation of endosome organisation|down regulation of endosome organization|down regulation of endosome organization and biogenesis|down-regulation of endosome organisation|down-regulation of endosome organization|down-regulation of endosome organization and biogenesis|downregulation of endosome organisation|downregulation of endosome organization|downregulation of endosome organization and biogenesis|inhibition of endosome organisation|inhibition of endosome organization|inhibition of endosome organization and biogenesis|negative regulation of endosome organisation|negative regulation of endosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1904979 GO:1904978 biolink:BiologicalProcess regulation of endosome organization Any process that modulates the frequency, rate or extent of endosome organization. go.json regulation of endosome organisation|regulation of endosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1904978 GO:1904977 biolink:BiologicalProcess lymphatic endothelial cell migration The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel. go.json http://purl.obolibrary.org/obo/GO_1904977 GO:1904976 biolink:BiologicalProcess cellular response to bleomycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904976 GO:1904975 biolink:BiologicalProcess response to bleomycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904975 GO:1904974 biolink:CellularComponent heparanase complex A protein complex which is capable of heparanase activity. go.json HEPS complex http://purl.obolibrary.org/obo/GO_1904974 GO:0047159 biolink:MolecularActivity 1-alkenylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. EC:2.3.1.25|MetaCyc:PLASMALOGEN-SYNTHASE-RXN|RHEA:10344 go.json acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047159 GO:0047158 biolink:MolecularActivity sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose. EC:2.3.1.103|KEGG_REACTION:R00063|MetaCyc:2.3.1.103-RXN|RHEA:22664 go.json 1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity|1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity|hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047158 GO:1904973 biolink:BiologicalProcess positive regulation of viral translation Any process that activates or increases the frequency, rate or extent of viral translation. go.json activation of viral protein anabolism|activation of viral protein biosynthesis|activation of viral protein biosynthetic process|activation of viral protein formation|activation of viral protein synthesis|activation of viral translation|positive regulation of viral protein anabolism|positive regulation of viral protein biosynthesis|positive regulation of viral protein biosynthetic process|positive regulation of viral protein formation|positive regulation of viral protein synthesis|up regulation of viral protein anabolism|up regulation of viral protein biosynthesis|up regulation of viral protein biosynthetic process|up regulation of viral protein formation|up regulation of viral protein synthesis|up regulation of viral translation|up-regulation of viral protein anabolism|up-regulation of viral protein biosynthesis|up-regulation of viral protein biosynthetic process|up-regulation of viral protein formation|up-regulation of viral protein synthesis|up-regulation of viral translation|upregulation of viral protein anabolism|upregulation of viral protein biosynthesis|upregulation of viral protein biosynthetic process|upregulation of viral protein formation|upregulation of viral protein synthesis|upregulation of viral translation http://purl.obolibrary.org/obo/GO_1904973 GO:1904972 biolink:BiologicalProcess negative regulation of viral translation Any process that stops, prevents or reduces the frequency, rate or extent of viral translation. go.json down regulation of viral protein anabolism|down regulation of viral protein biosynthesis|down regulation of viral protein biosynthetic process|down regulation of viral protein formation|down regulation of viral protein synthesis|down regulation of viral translation|down-regulation of viral protein anabolism|down-regulation of viral protein biosynthesis|down-regulation of viral protein biosynthetic process|down-regulation of viral protein formation|down-regulation of viral protein synthesis|down-regulation of viral translation|downregulation of viral protein anabolism|downregulation of viral protein biosynthesis|downregulation of viral protein biosynthetic process|downregulation of viral protein formation|downregulation of viral protein synthesis|downregulation of viral translation|inhibition of viral protein anabolism|inhibition of viral protein biosynthesis|inhibition of viral protein biosynthetic process|inhibition of viral protein formation|inhibition of viral protein synthesis|inhibition of viral translation|negative regulation of viral protein anabolism|negative regulation of viral protein biosynthesis|negative regulation of viral protein biosynthetic process|negative regulation of viral protein formation|negative regulation of viral protein synthesis http://purl.obolibrary.org/obo/GO_1904972 GO:0047157 biolink:MolecularActivity myelin-proteolipid O-palmitoyltransferase activity Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA. EC:2.3.1.100|MetaCyc:2.3.1.100-RXN go.json [myelin-proteolipid] O-palmitoyltransferase activity|acyl-protein synthase activity|myelin PLP acyltransferase activity|palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0047157 GO:1904971 biolink:BiologicalProcess regulation of viral translation Any process that modulates the frequency, rate or extent of viral translation. go.json regulation of viral protein anabolism|regulation of viral protein biosynthesis|regulation of viral protein biosynthetic process|regulation of viral protein formation|regulation of viral protein synthesis http://purl.obolibrary.org/obo/GO_1904971 GO:0047156 biolink:MolecularActivity acetoin-ribose-5-phosphate transaldolase activity Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde. EC:2.2.1.4|KEGG_REACTION:R02345|MetaCyc:2.2.1.4-RXN|RHEA:21504 go.json 1-deoxy-D-altro-heptulose-7-phosphate synthase activity|1-deoxy-D-altro-heptulose-7-phosphate synthetase activity|3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity|3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity http://purl.obolibrary.org/obo/GO_0047156 GO:1904981 biolink:BiologicalProcess maltose transmembrane transport The process in which maltose is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904981 GO:1904980 biolink:BiologicalProcess positive regulation of endosome organization Any process that activates or increases the frequency, rate or extent of endosome organization. go.json activation of endosome organisation|activation of endosome organization|activation of endosome organization and biogenesis|positive regulation of endosome organisation|positive regulation of endosome organization and biogenesis|up regulation of endosome organisation|up regulation of endosome organization|up regulation of endosome organization and biogenesis|up-regulation of endosome organisation|up-regulation of endosome organization|up-regulation of endosome organization and biogenesis|upregulation of endosome organisation|upregulation of endosome organization|upregulation of endosome organization and biogenesis http://purl.obolibrary.org/obo/GO_1904980 GO:0072119 biolink:BiologicalProcess head kidney structural organization The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. go.json head kidney structural organisation http://purl.obolibrary.org/obo/GO_0072119 GO:0072118 biolink:BiologicalProcess pronephros structural organization The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. go.json pronephric kidney structural organization|pronephros structural organisation http://purl.obolibrary.org/obo/GO_0072118 GO:0072117 biolink:BiologicalProcess head kidney formation The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072117 GO:0072116 biolink:BiologicalProcess pronephros formation The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. go.json pronephric kidney formation http://purl.obolibrary.org/obo/GO_0072116 GO:0072115 biolink:BiologicalProcess head kidney morphogenesis The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072115 GO:0072114 biolink:BiologicalProcess pronephros morphogenesis The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. go.json pronephric kidney morphogenesis http://purl.obolibrary.org/obo/GO_0072114 GO:0072113 biolink:BiologicalProcess head kidney development The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis. go.json http://purl.obolibrary.org/obo/GO_0072113 GO:0072112 biolink:BiologicalProcess podocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. go.json glomerular visceral epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0072112 GO:0072100 biolink:BiologicalProcess specification of ureteric bud anterior/posterior symmetry The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis. go.json specification of ureteric bud anterior/posterior asymmetry http://purl.obolibrary.org/obo/GO_0072100 GO:0047166 biolink:MolecularActivity 1-alkenylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. EC:2.3.1.121|MetaCyc:2.3.1.121-RXN|RHEA:16245 go.json acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047166 GO:0047165 biolink:MolecularActivity flavonol-3-O-beta-glucoside O-malonyltransferase activity Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA. EC:2.3.1.116|MetaCyc:2.3.1.116-RXN|RHEA:20085 go.json MAT-3|flavonol 3-O-glucoside malonyltransferase activity|malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity|malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity http://purl.obolibrary.org/obo/GO_0047165 GO:0047164 biolink:MolecularActivity isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA. EC:2.3.1.115|MetaCyc:RXN-4703|RHEA:15581 go.json MAT-7|flavone (flavonol) 7-O-glycoside malonyltransferase activity|flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity|malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity|malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity|malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity|malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0047164 GO:0047163 biolink:MolecularActivity 3,4-dichloroaniline N-malonyltransferase activity Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA. EC:2.3.1.114|KEGG_REACTION:R04050|MetaCyc:2.3.1.114-RXN|RHEA:21060 go.json malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity http://purl.obolibrary.org/obo/GO_0047163 GO:0047162 biolink:MolecularActivity 17-O-deacetylvindoline O-acetyltransferase activity Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA. EC:2.3.1.107|KEGG_REACTION:R03230|MetaCyc:2.3.1.107-RXN|RHEA:24496 go.json 17-O-deacetylvindoline-17-O-acetyltransferase activity|DAT activity|acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity|acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity|acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity|acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity|acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity|acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity|deacetylvindoline O-acetyltransferase activity|deacetylvindoline acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047162 GO:0047161 biolink:MolecularActivity tartronate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate. EC:2.3.1.106|KEGG_REACTION:R03965|MetaCyc:2.3.1.106-RXN|RHEA:10952 go.json hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity|sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity|tartronate sinapoyltransferase activity http://purl.obolibrary.org/obo/GO_0047161 GO:0047160 biolink:MolecularActivity alkylglycerophosphate 2-O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA. EC:2.3.1.105|KEGG_REACTION:R03455|MetaCyc:2.3.1.105-RXN|RHEA:18557 go.json acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity|alkyllyso-GP:acetyl-CoA acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047160 GO:1904989 biolink:BiologicalProcess positive regulation of endothelial cell activation Any process that activates or increases the frequency, rate or extent of endothelial cell activation. go.json activation of endothelial cell activation|up regulation of endothelial cell activation|up-regulation of endothelial cell activation|upregulation of endothelial cell activation http://purl.obolibrary.org/obo/GO_1904989 GO:1904988 biolink:BiologicalProcess negative regulation of endothelial cell activation Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation. go.json down regulation of endothelial cell activation|down-regulation of endothelial cell activation|downregulation of endothelial cell activation|inhibition of endothelial cell activation http://purl.obolibrary.org/obo/GO_1904988 GO:1904987 biolink:BiologicalProcess regulation of endothelial cell activation Any process that modulates the frequency, rate or extent of endothelial cell activation. go.json http://purl.obolibrary.org/obo/GO_1904987 GO:1904986 biolink:BiologicalProcess positive regulation of quinolinate biosynthetic process Any process that activates or increases the frequency, rate or extent of quinolinate biosynthetic process. go.json activation of quinolinate anabolism|activation of quinolinate biosynthesis|activation of quinolinate biosynthetic process|activation of quinolinate formation|activation of quinolinate synthesis|positive regulation of quinolinate anabolism|positive regulation of quinolinate biosynthesis|positive regulation of quinolinate formation|positive regulation of quinolinate synthesis|up regulation of quinolinate anabolism|up regulation of quinolinate biosynthesis|up regulation of quinolinate biosynthetic process|up regulation of quinolinate formation|up regulation of quinolinate synthesis|up-regulation of quinolinate anabolism|up-regulation of quinolinate biosynthesis|up-regulation of quinolinate biosynthetic process|up-regulation of quinolinate formation|up-regulation of quinolinate synthesis|upregulation of quinolinate anabolism|upregulation of quinolinate biosynthesis|upregulation of quinolinate biosynthetic process|upregulation of quinolinate formation|upregulation of quinolinate synthesis http://purl.obolibrary.org/obo/GO_1904986 GO:1904985 biolink:BiologicalProcess negative regulation of quinolinate biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process. go.json down regulation of quinolinate anabolism|down regulation of quinolinate biosynthesis|down regulation of quinolinate biosynthetic process|down regulation of quinolinate formation|down regulation of quinolinate synthesis|down-regulation of quinolinate anabolism|down-regulation of quinolinate biosynthesis|down-regulation of quinolinate biosynthetic process|down-regulation of quinolinate formation|down-regulation of quinolinate synthesis|downregulation of quinolinate anabolism|downregulation of quinolinate biosynthesis|downregulation of quinolinate biosynthetic process|downregulation of quinolinate formation|downregulation of quinolinate synthesis|inhibition of quinolinate anabolism|inhibition of quinolinate biosynthesis|inhibition of quinolinate biosynthetic process|inhibition of quinolinate formation|inhibition of quinolinate synthesis|negative regulation of quinolinate anabolism|negative regulation of quinolinate biosynthesis|negative regulation of quinolinate formation|negative regulation of quinolinate synthesis http://purl.obolibrary.org/obo/GO_1904985 GO:1904984 biolink:BiologicalProcess regulation of quinolinate biosynthetic process Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process. go.json regulation of quinolinate anabolism|regulation of quinolinate biosynthesis|regulation of quinolinate formation|regulation of quinolinate synthesis http://purl.obolibrary.org/obo/GO_1904984 GO:0047169 biolink:MolecularActivity galactarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA. EC:2.3.1.130|KEGG_REACTION:R03727|MetaCyc:2.3.1.130-RXN|RHEA:12997 go.json feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity|galacturate hydroxycinnamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047169 GO:0047168 biolink:MolecularActivity isocitrate O-dihydroxycinnamoyltransferase activity Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA. EC:2.3.1.126|KEGG_REACTION:R01946|MetaCyc:2.3.1.126-RXN|RHEA:20756 go.json caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity http://purl.obolibrary.org/obo/GO_0047168 GO:1904983 biolink:BiologicalProcess glycine import into mitochondrion The process in which glycine is transported from the cytosol into the mitochondrial matrix. go.json transmembrane glycine transport from cytosol to mitochondrion http://purl.obolibrary.org/obo/GO_1904983 GO:0047167 biolink:MolecularActivity 1-alkyl-2-acetylglycerol O-acyltransferase activity Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA. EC:2.3.1.125|MetaCyc:2.3.1.125-RXN|RHEA:21996 go.json 1-hexadecyl-2-acetylglycerol acyltransferase activity|acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047167 GO:1904982 biolink:BiologicalProcess sucrose transmembrane transport The process in which sucrose is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904982 GO:1904992 biolink:BiologicalProcess positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. go.json activation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|activation of dopamine receptor, adenylate cyclase inhibiting pathway|activation of dopamine receptor, adenylyl cyclase inhibiting pathway|activation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|activation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|positive regulation of dopamine receptor, adenylate cyclase inhibiting pathway|positive regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|up regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|up regulation of dopamine receptor, adenylate cyclase inhibiting pathway|up regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|up regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|up regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|up-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|up-regulation of dopamine receptor, adenylate cyclase inhibiting pathway|up-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|upregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|upregulation of dopamine receptor, adenylate cyclase inhibiting pathway|upregulation of dopamine receptor, adenylyl cyclase inhibiting pathway|upregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|upregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_1904992 GO:1904991 biolink:BiologicalProcess negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. go.json down regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|down regulation of dopamine receptor, adenylate cyclase inhibiting pathway|down regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|down regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|down regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|down-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|down-regulation of dopamine receptor, adenylate cyclase inhibiting pathway|down-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|downregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway|downregulation of dopamine receptor, adenylate cyclase inhibiting pathway|downregulation of dopamine receptor, adenylyl cyclase inhibiting pathway|downregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|downregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|inhibition of adenylate cyclase-inhibiting dopamine receptor signaling pathway|inhibition of dopamine receptor, adenylate cyclase inhibiting pathway|inhibition of dopamine receptor, adenylyl cyclase inhibiting pathway|inhibition of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|negative regulation of dopamine receptor, adenylate cyclase inhibiting pathway|negative regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_1904991 GO:1904990 biolink:BiologicalProcess regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. go.json regulation of dopamine receptor, adenylate cyclase inhibiting pathway|regulation of dopamine receptor, adenylyl cyclase inhibiting pathway|regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_1904990 GO:0072109 biolink:BiologicalProcess glomerular mesangium development The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072109 GO:0072108 biolink:BiologicalProcess positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072108 GO:0072107 biolink:BiologicalProcess positive regulation of ureteric bud formation Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. go.json http://purl.obolibrary.org/obo/GO_0072107 GO:0072106 biolink:BiologicalProcess regulation of ureteric bud formation Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. go.json http://purl.obolibrary.org/obo/GO_0072106 GO:0072105 biolink:BiologicalProcess ureteric peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. go.json http://purl.obolibrary.org/obo/GO_0072105 GO:0072104 biolink:BiologicalProcess glomerular capillary formation The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0072104 GO:0072103 biolink:BiologicalProcess glomerulus vasculature morphogenesis The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072103 GO:0072102 biolink:BiologicalProcess glomerulus morphogenesis The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. go.json http://purl.obolibrary.org/obo/GO_0072102 GO:0072101 biolink:BiologicalProcess obsolete specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis. go.json specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway|specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway True http://purl.obolibrary.org/obo/GO_0072101 GO:0072133 biolink:BiologicalProcess metanephric mesenchyme morphogenesis The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072133 GO:0047177 biolink:MolecularActivity glycerophospholipid arachidonoyl-transferase (CoA-independent) activity Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine. EC:2.3.1.147|MetaCyc:2.3.1.147-RXN|RHEA:15409 go.json 1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)|1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent) http://purl.obolibrary.org/obo/GO_0047177 GO:0072132 biolink:BiologicalProcess mesenchyme morphogenesis The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. go.json http://purl.obolibrary.org/obo/GO_0072132 GO:0047176 biolink:MolecularActivity beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose. EC:2.3.1.143|KEGG_REACTION:R04498|MetaCyc:2.3.1.143-RXN|RHEA:19109 go.json 1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity|beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity|beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity|beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity http://purl.obolibrary.org/obo/GO_0047176 GO:0047175 biolink:MolecularActivity galactosylacylglycerol O-acyltransferase activity Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]. EC:2.3.1.141|MetaCyc:2.3.1.141-RXN|RHEA:17057 go.json acyl-ACP:lyso-MGDG acyltransferase activity|acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity|acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047175 GO:0072131 biolink:BiologicalProcess kidney mesenchyme morphogenesis The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. go.json http://purl.obolibrary.org/obo/GO_0072131 GO:0047174 biolink:MolecularActivity putrescine N-hydroxycinnamoyltransferase activity Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H+. EC:2.3.1.138|KEGG_REACTION:R01944|MetaCyc:2.3.1.138-RXN|RHEA:12436 go.json PHT|caffeoyl-CoA putrescine N-caffeoyl transferase activity|caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity|hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity|putrescine hydroxycinnamoyl transferase activity|putrescine hydroxycinnamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047174 GO:0072130 biolink:BiologicalProcess renal capsule specification The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0072130 GO:0047173 biolink:MolecularActivity phosphatidylcholine-retinol O-acyltransferase activity Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. EC:2.3.1.135|MetaCyc:2.3.1.135-RXN|RHEA:17469|Reactome:R-HSA-975608 go.json lecithin--retinol acyltransferase activity|phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity|phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047173 GO:0047172 biolink:MolecularActivity shikimate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA. EC:2.3.1.133|MetaCyc:2.3.1.133-RXN|RHEA:12124 go.json 4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity|shikimate hydroxycinnamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047172 GO:0047171 biolink:MolecularActivity glucarolactone O-hydroxycinnamoyltransferase activity Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA. EC:2.3.1.132|MetaCyc:2.3.1.132-RXN|RHEA:14261 go.json sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity http://purl.obolibrary.org/obo/GO_0047171 GO:0047170 biolink:MolecularActivity glucarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA. EC:2.3.1.131|KEGG_REACTION:R02899|MetaCyc:2.3.1.131-RXN|RHEA:23308 go.json sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity http://purl.obolibrary.org/obo/GO_0047170 GO:1904999 biolink:BiologicalProcess positive regulation of leukocyte adhesion to arterial endothelial cell Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. go.json activation of leukocyte adhesion to arterial endothelial cell|up regulation of leukocyte adhesion to arterial endothelial cell|up-regulation of leukocyte adhesion to arterial endothelial cell|upregulation of leukocyte adhesion to arterial endothelial cell http://purl.obolibrary.org/obo/GO_1904999 GO:1904998 biolink:BiologicalProcess negative regulation of leukocyte adhesion to arterial endothelial cell Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. go.json down regulation of leukocyte adhesion to arterial endothelial cell|down-regulation of leukocyte adhesion to arterial endothelial cell|downregulation of leukocyte adhesion to arterial endothelial cell|inhibition of leukocyte adhesion to arterial endothelial cell http://purl.obolibrary.org/obo/GO_1904998 GO:1904997 biolink:BiologicalProcess regulation of leukocyte adhesion to arterial endothelial cell Any process that modulates the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. go.json http://purl.obolibrary.org/obo/GO_1904997 GO:1904996 biolink:BiologicalProcess positive regulation of leukocyte adhesion to vascular endothelial cell Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. go.json activation of leukocyte adhesion to vascular endothelial cell|up regulation of leukocyte adhesion to vascular endothelial cell|up-regulation of leukocyte adhesion to vascular endothelial cell|upregulation of leukocyte adhesion to vascular endothelial cell http://purl.obolibrary.org/obo/GO_1904996 GO:1904995 biolink:BiologicalProcess negative regulation of leukocyte adhesion to vascular endothelial cell Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. go.json down regulation of leukocyte adhesion to vascular endothelial cell|down-regulation of leukocyte adhesion to vascular endothelial cell|downregulation of leukocyte adhesion to vascular endothelial cell|inhibition of leukocyte adhesion to vascular endothelial cell http://purl.obolibrary.org/obo/GO_1904995 GO:1904994 biolink:BiologicalProcess regulation of leukocyte adhesion to vascular endothelial cell Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. go.json http://purl.obolibrary.org/obo/GO_1904994 GO:0047179 biolink:MolecularActivity platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. EC:2.3.1.149|MetaCyc:2.3.1.149-RXN|RHEA:11048 go.json 1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity|PAF acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047179 GO:1904993 biolink:BiologicalProcess obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle OBSOLETE. Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in positive regulation of G2/M transition of mitotic cell cycle. go.json activation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle|activation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry|positive regulation of CDK activity involved in positive regulation of G2/M transition of mitotic cell cycle|positive regulation of CDK activity involved in positive regulation of mitotic entry|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of mitotic entry|stimulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle|stimulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry|up regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle|up regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry|up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle|up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry|upregulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle|upregulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry True http://purl.obolibrary.org/obo/GO_1904993 GO:0047178 biolink:MolecularActivity glycerophospholipid acyltransferase (CoA-dependent) activity Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine. EC:2.3.1.148|MetaCyc:2.3.1.148-RXN|RHEA:20972 go.json 1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent) http://purl.obolibrary.org/obo/GO_0047178 GO:0047180 biolink:MolecularActivity salutaridinol 7-O-acetyltransferase activity Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA. EC:2.3.1.150|KEGG_REACTION:R04723|MetaCyc:2.3.1.150-RXN|RHEA:22856 go.json acetyl-CoA:salutaridinol 7-O-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047180 GO:0072139 biolink:BiologicalProcess glomerular parietal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. go.json http://purl.obolibrary.org/obo/GO_0072139 GO:0072138 biolink:BiologicalProcess mesenchymal cell proliferation involved in ureteric bud development The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development. go.json ureteric bud mesenchymal cell proliferation http://purl.obolibrary.org/obo/GO_0072138 GO:0072137 biolink:BiologicalProcess condensed mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072137 GO:0072136 biolink:BiologicalProcess metanephric mesenchymal cell proliferation involved in metanephros development The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population. go.json http://purl.obolibrary.org/obo/GO_0072136 GO:0072135 biolink:BiologicalProcess kidney mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney. go.json http://purl.obolibrary.org/obo/GO_0072135 GO:0072134 biolink:BiologicalProcess nephrogenic mesenchyme morphogenesis The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron. go.json http://purl.obolibrary.org/obo/GO_0072134 GO:0047188 biolink:MolecularActivity aromatic-hydroxylamine O-acetyltransferase activity Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl. EC:2.3.1.56|MetaCyc:2.3.1.56-RXN|RHEA:20325 go.json N,O-acetyltransferase activity|N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity|N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity|aromatic hydroxylamine acetyltransferase activity|arylhydroxamate acyltransferase activity|arylhydroxamic acid N,O-acetyltransferase activity|arylhydroxamic acyltransferase activity http://purl.obolibrary.org/obo/GO_0047188 GO:0072122 biolink:BiologicalProcess extraglomerular mesangial cell proliferation The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. go.json Goormaghtigh proliferation|lacis cell proliferation http://purl.obolibrary.org/obo/GO_0072122 GO:0047187 biolink:MolecularActivity deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate. EC:2.3.1.49|MetaCyc:2.3.1.49-RXN|RHEA:20393 go.json S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity|S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity|deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity|deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047187 GO:0072121 biolink:BiologicalProcess head kidney maturation A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072121 GO:0047186 biolink:MolecularActivity N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA. EC:2.3.1.45|MetaCyc:2.3.1.45-RXN|RHEA:20808 go.json N-acetylneuraminate 7(8)-O-acetyltransferase activity|N-acetylneuraminate 7,8-O-acetyltransferase activity|N-acetylneuraminate O7-(or O9-)acetyltransferase activity|acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity|glycoprotein 7(9)-O-acetyltransferase activity|sialate O-acetyltransferase http://purl.obolibrary.org/obo/GO_0047186 GO:0072120 biolink:BiologicalProcess pronephros maturation A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. go.json pronephric kidney maturation http://purl.obolibrary.org/obo/GO_0072120 GO:0047185 biolink:MolecularActivity N-acetylneuraminate 4-O-acetyltransferase activity Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA. EC:2.3.1.44|KEGG_REACTION:R01806|MetaCyc:2.3.1.44-RXN|RHEA:18305 go.json acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity|sialate O-acetyltransferase http://purl.obolibrary.org/obo/GO_0047185 GO:0047184 biolink:MolecularActivity 1-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. EC:2.3.1.23|MetaCyc:2.3.1.23-RXN|RHEA:12937|Reactome:R-HSA-1482794 go.json 1-acyl-sn-glycero-3-phosphocholine acyltransferase activity|acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity|acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity|acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity|lysolecithin acyltransferase activity|lysophosphatide acyltransferase activity|lysophosphatidylcholine acyltransferase activity http://purl.obolibrary.org/obo/GO_0047184 GO:0047183 biolink:MolecularActivity anthocyanin 5-aromatic acyltransferase activity Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA. EC:2.3.1.153|MetaCyc:RXN-7945|RHEA:15661 go.json hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047183 GO:0047182 biolink:MolecularActivity alcohol O-cinnamoyltransferase activity Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate. EC:2.3.1.152|MetaCyc:2.3.1.152-RXN|RHEA:23524 go.json 1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity http://purl.obolibrary.org/obo/GO_0047182 GO:0047181 biolink:MolecularActivity tetrahydroxybenzophenone synthase activity Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A. EC:2.3.1.151|MetaCyc:2.3.1.151-RXN|RHEA:19305 go.json malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity http://purl.obolibrary.org/obo/GO_0047181 GO:0047189 biolink:MolecularActivity 2,3-diaminopropionate N-oxalyltransferase activity Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA. EC:2.3.1.58|KEGG_REACTION:R04211|MetaCyc:2.3.1.58-RXN|RHEA:13465 go.json ODAP synthase activity|oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity|oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity|oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity|oxalyldiaminopropionate synthase activity|oxalyldiaminopropionic synthase activity http://purl.obolibrary.org/obo/GO_0047189 GO:0047191 biolink:MolecularActivity 1-alkylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA. EC:2.3.1.63|MetaCyc:2.3.1.63-RXN|RHEA:23992 go.json acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047191 GO:0072129 biolink:BiologicalProcess renal capsule formation The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. go.json http://purl.obolibrary.org/obo/GO_0072129 GO:0047190 biolink:MolecularActivity 2-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA. EC:2.3.1.62|KEGG_REACTION:R01319|MetaCyc:2.3.1.62-RXN|RHEA:10332 go.json 2-acylglycerol-3-phosphorylcholine acyltransferase activity|2-acylglycerophosphocholine acyltransferase activity|acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047190 GO:0072128 biolink:BiologicalProcess renal capsule morphogenesis The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. go.json http://purl.obolibrary.org/obo/GO_0072128 GO:0072127 biolink:BiologicalProcess renal capsule development The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. go.json http://purl.obolibrary.org/obo/GO_0072127 GO:0072126 biolink:BiologicalProcess positive regulation of glomerular mesangial cell proliferation Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0072126 GO:0072125 biolink:BiologicalProcess negative regulation of glomerular mesangial cell proliferation Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0072125 GO:0072124 biolink:BiologicalProcess regulation of glomerular mesangial cell proliferation Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0072124 GO:0072123 biolink:BiologicalProcess intraglomerular mesangial cell proliferation The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0072123 GO:0047199 biolink:MolecularActivity phosphatidylcholine-dolichol O-acyltransferase activity Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol. EC:2.3.1.83|KEGG_REACTION:R04227|MetaCyc:2.3.1.83-RXN|RHEA:19285 go.json 3-sn-phosphatidylcholine:dolichol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047199 GO:0072155 biolink:BiologicalProcess epithelial cell migration involved in nephron tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0072155 GO:0072154 biolink:BiologicalProcess proximal convoluted tubule segment 1 cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney. go.json S1 cell fate commitment http://purl.obolibrary.org/obo/GO_0072154 GO:0047198 biolink:MolecularActivity cysteine-S-conjugate N-acetyltransferase activity Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+. EC:2.3.1.80|KEGG_REACTION:R04950|MetaCyc:2.3.1.80-RXN|RHEA:19213|Reactome:R-HSA-5433066 go.json acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047198 GO:0047197 biolink:MolecularActivity triglyceride-sterol O-acyltransferase activity Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol. EC:2.3.1.77|MetaCyc:2.3.1.77-RXN|RHEA:16897 go.json triacylglycerol-sterol O-acyltransferase activity|triacylglycerol:3beta-hydroxysterol O-acyltransferase activity|triacylglycerol:sterol acyltransferase activity http://purl.obolibrary.org/obo/GO_0047197 GO:0072153 biolink:BiologicalProcess renal interstitial fibroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast. go.json kidney interstitial cell fate commitment http://purl.obolibrary.org/obo/GO_0072153 GO:0072152 biolink:BiologicalProcess glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell. go.json http://purl.obolibrary.org/obo/GO_0072152 GO:0047196 biolink:MolecularActivity long-chain-alcohol O-fatty-acyltransferase activity Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. EC:2.3.1.75|MetaCyc:2.3.1.75-RXN|MetaCyc:RXNQT-4193|RHEA:38443|Reactome:R-HSA-5696424|Reactome:R-HSA-8848582 go.json acyl-CoA:long-chain-alcohol O-acyltransferase activity|wax ester synthase activity|wax synthase activity|wax-ester synthase activity http://purl.obolibrary.org/obo/GO_0047196 GO:0072151 biolink:BiologicalProcess mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell. go.json http://purl.obolibrary.org/obo/GO_0072151 GO:0047195 biolink:MolecularActivity diacylglycerol-sterol O-acyltransferase activity Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol. EC:2.3.1.73|MetaCyc:2.3.1.73-RXN|RHEA:13301 go.json 1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity|1,2-diacyl-sn-glycerol:sterol acyl transferase activity http://purl.obolibrary.org/obo/GO_0047195 GO:0072150 biolink:BiologicalProcess juxtaglomerulus cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell. go.json http://purl.obolibrary.org/obo/GO_0072150 GO:0047194 biolink:MolecularActivity indoleacetylglucose-inositol O-acyltransferase activity Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose. EC:2.3.1.72|KEGG_REACTION:R04333|MetaCyc:2.3.1.72-RXN|RHEA:21180 go.json 1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity|1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity|indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity http://purl.obolibrary.org/obo/GO_0047194 GO:0047193 biolink:MolecularActivity obsolete CDP-acylglycerol O-arachidonoyltransferase activity OBSOLETE. Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA. MetaCyc:2.3.1.70-RXN go.json CDP-acylglycerol O-arachidonoyltransferase activity|CDP-acylglycerol O-arachidonyltransferase activity|CDPacylglycerol O-arachidonyltransferase activity|arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity|arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity True http://purl.obolibrary.org/obo/GO_0047193 GO:0047192 biolink:MolecularActivity 1-alkylglycerophosphocholine O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. EC:2.3.1.67|MetaCyc:2.3.1.67-RXN|RHEA:18461 go.json 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity|1-alkyl-2-lysolecithin acetyltransferase activity|acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity|acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity|acetyl-CoA:lyso-PAF acetyltransferase activity|acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity|blood platelet-activating factor acetyltransferase activity|lyso-GPC:acetyl CoA acetyltransferase activity|lyso-platelet activating factor:acetyl-CoA acetyltransferase activity|lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity|lysopaf:acetyl CoA acetyltransferase activity|platelet-activating factor acylhydrolase activity|platelet-activating factor-synthesizing enzyme activity http://purl.obolibrary.org/obo/GO_0047192 GO:0072159 biolink:BiologicalProcess epithelial cell migration involved in proximal tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0072159 GO:0072158 biolink:BiologicalProcess proximal tubule morphogenesis The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. go.json http://purl.obolibrary.org/obo/GO_0072158 GO:0072157 biolink:BiologicalProcess epithelial cell migration involved in distal tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0072157 GO:0072156 biolink:BiologicalProcess distal tubule morphogenesis The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. go.json http://purl.obolibrary.org/obo/GO_0072156 GO:0072144 biolink:BiologicalProcess glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072144 GO:0072143 biolink:BiologicalProcess mesangial cell development The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072143 GO:0072142 biolink:BiologicalProcess juxtaglomerulus cell development The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072142 GO:0072141 biolink:BiologicalProcess renal interstitial fibroblast development The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure. go.json kidney interstitial cell development http://purl.obolibrary.org/obo/GO_0072141 GO:0072140 biolink:BiologicalProcess DCT cell development The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure. go.json distal convoluted tubule cell development http://purl.obolibrary.org/obo/GO_0072140 GO:0072149 biolink:BiologicalProcess podocyte cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. go.json glomerular visceral epithelial cell fate commitment http://purl.obolibrary.org/obo/GO_0072149 GO:0072148 biolink:BiologicalProcess epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0072148 GO:0072147 biolink:BiologicalProcess glomerular parietal epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. go.json Bowman's capsule cell fate commitment http://purl.obolibrary.org/obo/GO_0072147 GO:0072146 biolink:BiologicalProcess DCT cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell. go.json distal convoluted tubule cell fate commitment http://purl.obolibrary.org/obo/GO_0072146 GO:0072145 biolink:BiologicalProcess proximal convoluted tubule segment 1 cell development The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure. go.json S1 cell development http://purl.obolibrary.org/obo/GO_0072145 GO:1904909 biolink:BiologicalProcess positive regulation of maintenance of mitotic sister chromatid cohesion, telomeric Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. go.json activation of maintenance of mitotic sister chromatid cohesion, telomeric|activation of maintenance of mitotic sister chromatin cohesion at telomere|activation of maintenance of sister chromatin cohesion at telomere at mitosis|activation of maintenance of telomeric mitotic sister chromatin cohesion|positive regulation of maintenance of mitotic sister chromatin cohesion at telomere|positive regulation of maintenance of sister chromatin cohesion at telomere at mitosis|positive regulation of maintenance of telomeric mitotic sister chromatin cohesion|up regulation of maintenance of mitotic sister chromatid cohesion, telomeric|up regulation of maintenance of mitotic sister chromatin cohesion at telomere|up regulation of maintenance of sister chromatin cohesion at telomere at mitosis|up regulation of maintenance of telomeric mitotic sister chromatin cohesion|up-regulation of maintenance of mitotic sister chromatid cohesion, telomeric|up-regulation of maintenance of mitotic sister chromatin cohesion at telomere|up-regulation of maintenance of sister chromatin cohesion at telomere at mitosis|up-regulation of maintenance of telomeric mitotic sister chromatin cohesion|upregulation of maintenance of mitotic sister chromatid cohesion, telomeric|upregulation of maintenance of mitotic sister chromatin cohesion at telomere|upregulation of maintenance of sister chromatin cohesion at telomere at mitosis|upregulation of maintenance of telomeric mitotic sister chromatin cohesion http://purl.obolibrary.org/obo/GO_1904909 GO:1904908 biolink:BiologicalProcess negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. go.json down regulation of maintenance of mitotic sister chromatid cohesion, telomeric|down regulation of maintenance of mitotic sister chromatin cohesion at telomere|down regulation of maintenance of sister chromatin cohesion at telomere at mitosis|down regulation of maintenance of telomeric mitotic sister chromatin cohesion|down-regulation of maintenance of mitotic sister chromatid cohesion, telomeric|down-regulation of maintenance of mitotic sister chromatin cohesion at telomere|down-regulation of maintenance of sister chromatin cohesion at telomere at mitosis|down-regulation of maintenance of telomeric mitotic sister chromatin cohesion|downregulation of maintenance of mitotic sister chromatid cohesion, telomeric|downregulation of maintenance of mitotic sister chromatin cohesion at telomere|downregulation of maintenance of sister chromatin cohesion at telomere at mitosis|downregulation of maintenance of telomeric mitotic sister chromatin cohesion|inhibition of maintenance of mitotic sister chromatid cohesion, telomeric|inhibition of maintenance of mitotic sister chromatin cohesion at telomere|inhibition of maintenance of sister chromatin cohesion at telomere at mitosis|inhibition of maintenance of telomeric mitotic sister chromatin cohesion|negative regulation of maintenance of mitotic sister chromatin cohesion at telomere|negative regulation of maintenance of sister chromatin cohesion at telomere at mitosis|negative regulation of maintenance of telomeric mitotic sister chromatin cohesion http://purl.obolibrary.org/obo/GO_1904908 GO:1904907 biolink:BiologicalProcess regulation of maintenance of mitotic sister chromatid cohesion, telomeric Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. go.json regulation of maintenance of mitotic sister chromatin cohesion at telomere|regulation of maintenance of sister chromatin cohesion at telomere at mitosis|regulation of maintenance of telomeric mitotic sister chromatin cohesion http://purl.obolibrary.org/obo/GO_1904907 GO:1904906 biolink:BiologicalProcess positive regulation of endothelial cell-matrix adhesion via fibronectin Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin. go.json activation of endothelial cell-matrix adhesion via fibronectin|up regulation of endothelial cell-matrix adhesion via fibronectin|up-regulation of endothelial cell-matrix adhesion via fibronectin|upregulation of endothelial cell-matrix adhesion via fibronectin http://purl.obolibrary.org/obo/GO_1904906 GO:1904905 biolink:BiologicalProcess negative regulation of endothelial cell-matrix adhesion via fibronectin Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin. go.json down regulation of endothelial cell-matrix adhesion via fibronectin|down-regulation of endothelial cell-matrix adhesion via fibronectin|downregulation of endothelial cell-matrix adhesion via fibronectin|inhibition of endothelial cell-matrix adhesion via fibronectin http://purl.obolibrary.org/obo/GO_1904905 GO:1904904 biolink:BiologicalProcess regulation of endothelial cell-matrix adhesion via fibronectin Any process that modulates the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin. go.json http://purl.obolibrary.org/obo/GO_1904904 GO:1904903 biolink:BiologicalProcess ESCRT III complex disassembly The disaggregation of an ESCRT III complex into its constituent components. go.json http://purl.obolibrary.org/obo/GO_1904903 GO:1904902 biolink:BiologicalProcess ESCRT III complex assembly The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex. go.json ESCRT III complex formation http://purl.obolibrary.org/obo/GO_1904902 GO:1904901 biolink:BiologicalProcess positive regulation of myosin II filament organization Any process that activates or increases the frequency, rate or extent of myosin II filament organization. go.json activation of myosin II filament assembly or disassembly|activation of myosin II filament organisation|activation of myosin II filament organization|activation of myosin II polymerization or depolymerization|positive regulation of myosin II filament assembly or disassembly|positive regulation of myosin II filament organisation|positive regulation of myosin II polymerization or depolymerization|up regulation of myosin II filament assembly or disassembly|up regulation of myosin II filament organisation|up regulation of myosin II filament organization|up regulation of myosin II polymerization or depolymerization|up-regulation of myosin II filament assembly or disassembly|up-regulation of myosin II filament organisation|up-regulation of myosin II filament organization|up-regulation of myosin II polymerization or depolymerization|upregulation of myosin II filament assembly or disassembly|upregulation of myosin II filament organisation|upregulation of myosin II filament organization|upregulation of myosin II polymerization or depolymerization http://purl.obolibrary.org/obo/GO_1904901 GO:1904900 biolink:BiologicalProcess negative regulation of myosin II filament organization Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament organization. go.json down regulation of myosin II filament assembly or disassembly|down regulation of myosin II filament organisation|down regulation of myosin II filament organization|down regulation of myosin II polymerization or depolymerization|down-regulation of myosin II filament assembly or disassembly|down-regulation of myosin II filament organisation|down-regulation of myosin II filament organization|down-regulation of myosin II polymerization or depolymerization|downregulation of myosin II filament assembly or disassembly|downregulation of myosin II filament organisation|downregulation of myosin II filament organization|downregulation of myosin II polymerization or depolymerization|inhibition of myosin II filament assembly or disassembly|inhibition of myosin II filament organisation|inhibition of myosin II filament organization|inhibition of myosin II polymerization or depolymerization|negative regulation of myosin II filament assembly or disassembly|negative regulation of myosin II filament organisation|negative regulation of myosin II polymerization or depolymerization http://purl.obolibrary.org/obo/GO_1904900 GO:1904919 biolink:BiologicalProcess transmembrane L-cystine transport from lysosomal lumen to cytosol The directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_1904919 GO:1904918 biolink:BiologicalProcess transmembrane L-histidine transport from lysosomal lumen to cytosol The directed movement of L-histidine from the lysosomal lumen across the lysosomal membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_1904918 GO:1904917 biolink:BiologicalProcess L-arginine transmembrane transport from lysosomal lumen to cytosol The directed movement of L-arginine across a membrane from lysosomal lumen to cytosol. go.json transmembrane L-arginine transport from lysosomal lumen to cytosol http://purl.obolibrary.org/obo/GO_1904917 GO:1904916 biolink:BiologicalProcess transmembrane L-lysine transport from lysosomal lumen to cytosol The directed movement of L-lysine from the lysosomal lumen across the lysosomal membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_1904916 GO:1904915 biolink:BiologicalProcess positive regulation of establishment of protein-containing complex localization to telomere Any process that activates or increases the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere. go.json activation of establishment of macromolecular complex localisation to telomere|activation of establishment of macromolecular complex localization to telomere|positive regulation of establishment of macromolecular complex localisation to telomere|positive regulation of establishment of macromolecular complex localization to telomere|up regulation of establishment of macromolecular complex localisation to telomere|up regulation of establishment of macromolecular complex localization to telomere|up-regulation of establishment of macromolecular complex localisation to telomere|up-regulation of establishment of macromolecular complex localization to telomere|upregulation of establishment of macromolecular complex localisation to telomere|upregulation of establishment of macromolecular complex localization to telomere http://purl.obolibrary.org/obo/GO_1904915 GO:1904914 biolink:BiologicalProcess negative regulation of establishment of protein-containing complex localization to telomere Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere. go.json down regulation of establishment of macromolecular complex localisation to telomere|down regulation of establishment of macromolecular complex localization to telomere|down-regulation of establishment of macromolecular complex localisation to telomere|down-regulation of establishment of macromolecular complex localization to telomere|downregulation of establishment of macromolecular complex localisation to telomere|downregulation of establishment of macromolecular complex localization to telomere|inhibition of establishment of macromolecular complex localisation to telomere|inhibition of establishment of macromolecular complex localization to telomere|negative regulation of establishment of macromolecular complex localisation to telomere|negative regulation of establishment of macromolecular complex localization to telomere http://purl.obolibrary.org/obo/GO_1904914 GO:1904913 biolink:BiologicalProcess regulation of establishment of protein-containing complex localization to telomere Any process that modulates the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere. go.json regulation of establishment of macromolecular complex localisation to telomere|regulation of establishment of macromolecular complex localization to telomere http://purl.obolibrary.org/obo/GO_1904913 GO:1904912 biolink:BiologicalProcess positive regulation of establishment of RNA localization to telomere Any process that activates or increases the frequency, rate or extent of establishment of RNA localization to telomere. go.json activation of establishment of RNA localisation to telomere|activation of establishment of RNA localization to telomere|positive regulation of establishment of RNA localisation to telomere|up regulation of establishment of RNA localisation to telomere|up regulation of establishment of RNA localization to telomere|up-regulation of establishment of RNA localisation to telomere|up-regulation of establishment of RNA localization to telomere|upregulation of establishment of RNA localisation to telomere|upregulation of establishment of RNA localization to telomere http://purl.obolibrary.org/obo/GO_1904912 GO:1904911 biolink:BiologicalProcess negative regulation of establishment of RNA localization to telomere Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere. go.json down regulation of establishment of RNA localisation to telomere|down regulation of establishment of RNA localization to telomere|down-regulation of establishment of RNA localisation to telomere|down-regulation of establishment of RNA localization to telomere|downregulation of establishment of RNA localisation to telomere|downregulation of establishment of RNA localization to telomere|inhibition of establishment of RNA localisation to telomere|inhibition of establishment of RNA localization to telomere|negative regulation of establishment of RNA localisation to telomere http://purl.obolibrary.org/obo/GO_1904911 GO:1904910 biolink:BiologicalProcess regulation of establishment of RNA localization to telomere Any process that modulates the frequency, rate or extent of establishment of RNA localization to telomere. go.json regulation of establishment of RNA localisation to telomere http://purl.obolibrary.org/obo/GO_1904910 GO:0047100 biolink:MolecularActivity glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate. EC:1.2.1.13|MetaCyc:1.2.1.13-RXN|RHEA:10296 go.json D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)|NADP-dependent glyceraldehyde phosphate dehydrogenase activity|NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity|NADP-triose phosphate dehydrogenase activity|dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)|glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)|triosephosphate dehydrogenase (NADP(+)) activity|triosephosphate dehydrogenase (NADP)|triosephosphate dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0047100 GO:1904929 biolink:MolecularActivity obsolete coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway OBSOLETE. Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway. go.json Wnt co-receptor activity, non-canonical signaling|Wnt co-receptor, non-canonical pathway|Wnt/PCP co-receptor activity|coreceptor activity involved in PCP pathway|coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway|coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway|coreceptor activity involved in Wnt-JNK signaling pathway|coreceptor activity involved in Wnt-PCP signaling pathway|coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway|coreceptor activity involved in non-canonical Wnt signaling pathway|coreceptor activity involved in planar cell polarity pathway|coreceptor, insoluble ligand activity involved in PCP pathway|coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway|coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway|coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway|coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway|coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway|coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway|coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway|coreceptor, insoluble ligand activity involved in planar cell polarity pathway|coreceptor, soluble ligand activity involved in PCP pathway|coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway|coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway|coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway|coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway|coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway|coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway|coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway|coreceptor, soluble ligand activity involved in planar cell polarity pathway True http://purl.obolibrary.org/obo/GO_1904929 GO:1904928 biolink:MolecularActivity obsolete coreceptor activity involved in canonical Wnt signaling pathway OBSOLETE. Any coreceptor activity that is involved in a canonical Wnt signaling pathway. go.json Wnt co-receptor activity, canonical signaling|Wnt co-receptor, canonical pathway|coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin|coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin|coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin|coreceptor activity involved in canonical Wnt receptor signaling pathway|coreceptor activity involved in canonical Wnt-activated signaling pathway|coreceptor activity involved in frizzled-1 receptor signaling pathway|coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin|coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin|coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin|coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway|coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway|coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway|coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway|coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin|coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin|coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin|coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway|coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway|coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway|coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway True http://purl.obolibrary.org/obo/GO_1904928 GO:1904927 biolink:BiologicalProcess cellular response to palmitoleic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1904927 GO:1904926 biolink:BiologicalProcess response to palmitoleic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1904926 GO:1904925 biolink:BiologicalProcess positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondrion in response to mitochondrial depolarization. go.json activation of mitophagy in response to mitochondrial depolarization|up regulation of mitophagy in response to mitochondrial depolarization|up-regulation of mitophagy in response to mitochondrial depolarization|upregulation of mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_1904925 GO:1904924 biolink:BiologicalProcess negative regulation of mitophagy in response to mitochondrial depolarization Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. go.json down regulation of mitophagy in response to mitochondrial depolarization|down-regulation of mitophagy in response to mitochondrial depolarization|downregulation of mitophagy in response to mitochondrial depolarization|inhibition of mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_1904924 GO:0047108 biolink:MolecularActivity (R)-3-hydroxyacid-ester dehydrogenase activity Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH. EC:1.1.1.279|KEGG_REACTION:R04105|MetaCyc:1.2.1.55-RXN|RHEA:24352 go.json (R)-3-hydroxyacid ester dehydrogenase activity|3-oxo ester (R)-reductase activity|ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047108 GO:1904923 biolink:BiologicalProcess regulation of autophagy of mitochondrion in response to mitochondrial depolarization Any process that modulates the frequency, rate or extent of autophagy of mitochondrion in response to mitochondrial depolarization. go.json http://purl.obolibrary.org/obo/GO_1904923 GO:1904922 biolink:BiologicalProcess obsolete positive regulation of MAPK cascade involved in axon regeneration OBSOLETE. Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration. go.json activation of ERK/MAPK cascade involved in axon regeneration|activation of MAP kinase cascade involved in axon regeneration|activation of MAP kinase kinase kinase cascade involved in axon regeneration|activation of MAPK cascade involved in axon regeneration|activation of MAPK signal transduction involved in axon regeneration|activation of MAPK signaling involved in axon regeneration|activation of MAPK signalling involved in axon regeneration|activation of MAPKKK cascade during sporulation involved in axon regeneration|activation of MAPKKK cascade involved in axon regeneration|activation of mitogen-activated protein kinase cascade involved in axon regeneration|positive regulation of ERK/MAPK cascade involved in axon regeneration|positive regulation of MAP kinase cascade involved in axon regeneration|positive regulation of MAP kinase kinase kinase cascade involved in axon regeneration|positive regulation of MAPK signal transduction involved in axon regeneration|positive regulation of MAPK signaling involved in axon regeneration|positive regulation of MAPK signalling involved in axon regeneration|positive regulation of MAPKKK cascade during sporulation involved in axon regeneration|positive regulation of MAPKKK cascade involved in axon regeneration|positive regulation of mitogen-activated protein kinase cascade involved in axon regeneration|up regulation of ERK/MAPK cascade involved in axon regeneration|up regulation of MAP kinase cascade involved in axon regeneration|up regulation of MAP kinase kinase kinase cascade involved in axon regeneration|up regulation of MAPK cascade involved in axon regeneration|up regulation of MAPK signal transduction involved in axon regeneration|up regulation of MAPK signaling involved in axon regeneration|up regulation of MAPK signalling involved in axon regeneration|up regulation of MAPKKK cascade during sporulation involved in axon regeneration|up regulation of MAPKKK cascade involved in axon regeneration|up regulation of mitogen-activated protein kinase cascade involved in axon regeneration|up-regulation of ERK/MAPK cascade involved in axon regeneration|up-regulation of MAP kinase cascade involved in axon regeneration|up-regulation of MAP kinase kinase kinase cascade involved in axon regeneration|up-regulation of MAPK cascade involved in axon regeneration|up-regulation of MAPK signal transduction involved in axon regeneration|up-regulation of MAPK signaling involved in axon regeneration|up-regulation of MAPK signalling involved in axon regeneration|up-regulation of MAPKKK cascade during sporulation involved in axon regeneration|up-regulation of MAPKKK cascade involved in axon regeneration|up-regulation of mitogen-activated protein kinase cascade involved in axon regeneration|upregulation of ERK/MAPK cascade involved in axon regeneration|upregulation of MAP kinase cascade involved in axon regeneration|upregulation of MAP kinase kinase kinase cascade involved in axon regeneration|upregulation of MAPK cascade involved in axon regeneration|upregulation of MAPK signal transduction involved in axon regeneration|upregulation of MAPK signaling involved in axon regeneration|upregulation of MAPK signalling involved in axon regeneration|upregulation of MAPKKK cascade during sporulation involved in axon regeneration|upregulation of MAPKKK cascade involved in axon regeneration|upregulation of mitogen-activated protein kinase cascade involved in axon regeneration True http://purl.obolibrary.org/obo/GO_1904922 GO:0047107 biolink:MolecularActivity gamma-guanidinobutyraldehyde dehydrogenase activity Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH. EC:1.2.1.54|KEGG_REACTION:R03177|MetaCyc:1.2.1.54-RXN|RHEA:14381 go.json 4-guanidinobutanal:NAD+ 1-oxidoreductase activity|4-guanidinobutyraldehyde dehydrogenase activity|GBAL dehydrogenase activity|alpha-guanidinobutyraldehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047107 GO:0047106 biolink:MolecularActivity 4-hydroxyphenylacetaldehyde dehydrogenase activity Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate. EC:1.2.1.53|MetaCyc:1.2.1.53-RXN|RHEA:17273 go.json 4-HPAL dehydrogenase activity|4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047106 GO:1904921 biolink:BiologicalProcess obsolete negative regulation of MAPK cascade involved in axon regeneration OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in axon regeneration. go.json down regulation of ERK/MAPK cascade involved in axon regeneration|down regulation of MAP kinase cascade involved in axon regeneration|down regulation of MAP kinase kinase kinase cascade involved in axon regeneration|down regulation of MAPK cascade involved in axon regeneration|down regulation of MAPK signal transduction involved in axon regeneration|down regulation of MAPK signaling involved in axon regeneration|down regulation of MAPK signalling involved in axon regeneration|down regulation of MAPKKK cascade during sporulation involved in axon regeneration|down regulation of MAPKKK cascade involved in axon regeneration|down regulation of mitogen-activated protein kinase cascade involved in axon regeneration|down-regulation of ERK/MAPK cascade involved in axon regeneration|down-regulation of MAP kinase cascade involved in axon regeneration|down-regulation of MAP kinase kinase kinase cascade involved in axon regeneration|down-regulation of MAPK cascade involved in axon regeneration|down-regulation of MAPK signal transduction involved in axon regeneration|down-regulation of MAPK signaling involved in axon regeneration|down-regulation of MAPK signalling involved in axon regeneration|down-regulation of MAPKKK cascade during sporulation involved in axon regeneration|down-regulation of MAPKKK cascade involved in axon regeneration|down-regulation of mitogen-activated protein kinase cascade involved in axon regeneration|downregulation of ERK/MAPK cascade involved in axon regeneration|downregulation of MAP kinase cascade involved in axon regeneration|downregulation of MAP kinase kinase kinase cascade involved in axon regeneration|downregulation of MAPK cascade involved in axon regeneration|downregulation of MAPK signal transduction involved in axon regeneration|downregulation of MAPK signaling involved in axon regeneration|downregulation of MAPK signalling involved in axon regeneration|downregulation of MAPKKK cascade during sporulation involved in axon regeneration|downregulation of MAPKKK cascade involved in axon regeneration|downregulation of mitogen-activated protein kinase cascade involved in axon regeneration|inhibition of ERK/MAPK cascade involved in axon regeneration|inhibition of MAP kinase cascade involved in axon regeneration|inhibition of MAP kinase kinase kinase cascade involved in axon regeneration|inhibition of MAPK cascade involved in axon regeneration|inhibition of MAPK signal transduction involved in axon regeneration|inhibition of MAPK signaling involved in axon regeneration|inhibition of MAPK signalling involved in axon regeneration|inhibition of MAPKKK cascade during sporulation involved in axon regeneration|inhibition of MAPKKK cascade involved in axon regeneration|inhibition of mitogen-activated protein kinase cascade involved in axon regeneration|negative regulation of ERK/MAPK cascade involved in axon regeneration|negative regulation of MAP kinase cascade involved in axon regeneration|negative regulation of MAP kinase kinase kinase cascade involved in axon regeneration|negative regulation of MAPK signal transduction involved in axon regeneration|negative regulation of MAPK signaling involved in axon regeneration|negative regulation of MAPK signalling involved in axon regeneration|negative regulation of MAPKKK cascade during sporulation involved in axon regeneration|negative regulation of MAPKKK cascade involved in axon regeneration|negative regulation of mitogen-activated protein kinase cascade involved in axon regeneration True http://purl.obolibrary.org/obo/GO_1904921 GO:1904920 biolink:BiologicalProcess obsolete regulation of MAPK cascade involved in axon regeneration OBSOLETE. Any process that modulates the frequency, rate or extent of MAPK cascade involved in axon regeneration. go.json regulation of ERK/MAPK cascade involved in axon regeneration|regulation of MAP kinase cascade involved in axon regeneration|regulation of MAP kinase kinase kinase cascade involved in axon regeneration|regulation of MAPK signal transduction involved in axon regeneration|regulation of MAPK signaling involved in axon regeneration|regulation of MAPK signalling involved in axon regeneration|regulation of MAPKKK cascade during sporulation involved in axon regeneration|regulation of MAPKKK cascade involved in axon regeneration|regulation of mitogen-activated protein kinase cascade involved in axon regeneration True http://purl.obolibrary.org/obo/GO_1904920 GO:0047105 biolink:MolecularActivity 4-trimethylammoniobutyraldehyde dehydrogenase activity Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. EC:1.2.1.47|MetaCyc:1.2.1.47-RXN|RHEA:17985|Reactome:R-HSA-71260 go.json 4-N-trimethylaminobutyraldehyde dehydrogenase activity|4-trimethylaminobutyraldehyde dehydrogenase activity|4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047105 GO:0047104 biolink:MolecularActivity hexadecanal dehydrogenase (acylating) activity Catalysis of the reaction: CoA + NAD+ + palmitaldehyde = H+ + NADH + palmitoyl-CoA. EC:1.2.1.42|KEGG_REACTION:R01277|MetaCyc:1.2.1.42-RXN|RHEA:19705|UM-BBD_reactionID:r1374 go.json fatty acyl-CoA reductase activity|hexadecanal:NAD+ oxidoreductase (CoA-acylating) http://purl.obolibrary.org/obo/GO_0047104 GO:0047103 biolink:MolecularActivity 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate. EC:1.14.15.15|MetaCyc:1.2.1.40-RXN|RHEA:34627 go.json 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity|3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity|THAL-NAD oxidoreductase activity|cholestanetriol-26-al 26-dehydrogenase activity|trihydroxydeoxycoprostanal dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047103 GO:0047102 biolink:MolecularActivity aminomuconate-semialdehyde dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate. EC:1.2.1.32|MetaCyc:1.2.1.32-RXN|RHEA:14469|Reactome:R-HSA-71239|UM-BBD_reactionID:r1434 go.json 2-aminomuconate semialdehyde dehydrogenase activity|2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity|2-hydroxymuconate semialdehyde dehydrogenase activity|2-hydroxymuconic acid semialdehyde dehydrogenase activity|2-hydroxymuconic semialdehyde dehydrogenase activity|alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity|alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047102 GO:0047101 biolink:MolecularActivity 2-oxoisovalerate dehydrogenase (acylating) activity Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA. EC:1.2.1.25|MetaCyc:1.2.1.25-RXN|RHEA:13997 go.json 2-oxoisovalerate dehydrogenase activity|3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating) http://purl.obolibrary.org/obo/GO_0047101 GO:0047109 biolink:MolecularActivity (S)-3-hydroxyacid-ester dehydrogenase activity Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH. EC:1.1.1.280|KEGG_REACTION:R04106|MetaCyc:1.2.1.56-RXN|RHEA:18269 go.json (S)-3-hydroxyacid ester dehydrogenase activity|3-oxo ester (S)-reductase activity|ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047109 GO:0047111 biolink:MolecularActivity formate dehydrogenase (cytochrome-c-553) activity Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. EC:1.17.2.3|MetaCyc:1.2.2.3-RXN|RHEA:15189 go.json formate dehydrogenase (cytochrome c-553)|formate:ferricytochrome-c-553 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047111 GO:0047110 biolink:MolecularActivity phenylglyoxylate dehydrogenase (acylating) activity Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH. EC:1.2.1.58|KEGG_REACTION:R02450|MetaCyc:1.2.1.58-RXN|RHEA:10372 go.json phenylglyoxylate:NAD+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047110 GO:1904939 biolink:BiologicalProcess obsolete regulation of DNA nucleotidylexotransferase activity OBSOLETE. Any process that modulates the frequency, rate or extent of DNA nucleotidylexotransferase activity. go.json regulation of TdT|regulation of addase activity|regulation of deoxynucleotidyl terminal transferase activity|regulation of deoxyribonucleic acid nucleotidyltransferase activity|regulation of deoxyribonucleic nucleotidyltransferase activity|regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|regulation of terminal addition enzyme activity|regulation of terminal deoxynucleotide transferase activity|regulation of terminal deoxynucleotidyltransferase activity|regulation of terminal deoxyribonucleotidyltransferase activity|regulation of terminal transferase activity True http://purl.obolibrary.org/obo/GO_1904939 GO:1904938 biolink:BiologicalProcess planar cell polarity pathway involved in axon guidance Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance. go.json PCP pathway involved in axon chemotaxis|PCP pathway involved in axon growth cone guidance|PCP pathway involved in axon guidance|PCP pathway involved in axon pathfinding|Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis|Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance|Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance|Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding|Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis|Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance|Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance|Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding|Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis|Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance|Wnt signaling pathway, planar cell polarity pathway involved in axon guidance|Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding|Wnt-JNK signaling pathway involved in axon chemotaxis|Wnt-JNK signaling pathway involved in axon growth cone guidance|Wnt-JNK signaling pathway involved in axon guidance|Wnt-JNK signaling pathway involved in axon pathfinding|Wnt-PCP signaling involved in axon guidance|Wnt-PCP signaling pathway involved in axon chemotaxis|Wnt-PCP signaling pathway involved in axon growth cone guidance|Wnt-PCP signaling pathway involved in axon guidance|Wnt-PCP signaling pathway involved in axon pathfinding|Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis|Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance|Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance|Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding|non-canonical Wnt signaling pathway involved in axon chemotaxis|non-canonical Wnt signaling pathway involved in axon growth cone guidance|non-canonical Wnt signaling pathway involved in axon guidance|non-canonical Wnt signaling pathway involved in axon pathfinding|planar cell polarity pathway involved in axon chemotaxis|planar cell polarity pathway involved in axon growth cone guidance|planar cell polarity pathway involved in axon pathfinding http://purl.obolibrary.org/obo/GO_1904938 GO:1904937 biolink:BiologicalProcess sensory neuron migration The orderly movement of a sensory neuron from one site to another. go.json http://purl.obolibrary.org/obo/GO_1904937 GO:1904936 biolink:BiologicalProcess interneuron migration The orderly movement of an interneuron from one site to another. go.json inter neuron migration|inter-neuron migration http://purl.obolibrary.org/obo/GO_1904936 GO:1904935 biolink:BiologicalProcess positive regulation of cell proliferation in midbrain Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. go.json activation of cell proliferation in mesencephalon|activation of cell proliferation in midbrain|activation of mesencepahalic cell proliferation|positive regulation of cell proliferation in mesencephalon|positive regulation of mesencepahalic cell proliferation|up regulation of cell proliferation in mesencephalon|up regulation of cell proliferation in midbrain|up regulation of mesencepahalic cell proliferation|up-regulation of cell proliferation in mesencephalon|up-regulation of cell proliferation in midbrain|up-regulation of mesencepahalic cell proliferation|upregulation of cell proliferation in mesencephalon|upregulation of cell proliferation in midbrain|upregulation of mesencepahalic cell proliferation http://purl.obolibrary.org/obo/GO_1904935 GO:1904934 biolink:BiologicalProcess negative regulation of cell proliferation in midbrain Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. go.json down regulation of cell proliferation in mesencephalon|down regulation of cell proliferation in midbrain|down regulation of mesencepahalic cell proliferation|down-regulation of cell proliferation in mesencephalon|down-regulation of cell proliferation in midbrain|down-regulation of mesencepahalic cell proliferation|downregulation of cell proliferation in mesencephalon|downregulation of cell proliferation in midbrain|downregulation of mesencepahalic cell proliferation|inhibition of cell proliferation in mesencephalon|inhibition of cell proliferation in midbrain|inhibition of mesencepahalic cell proliferation|negative regulation of cell proliferation in mesencephalon|negative regulation of mesencepahalic cell proliferation http://purl.obolibrary.org/obo/GO_1904934 GO:0047119 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047119 GO:1904933 biolink:BiologicalProcess regulation of cell proliferation in midbrain Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. go.json regulation of cell proliferation in mesencephalon|regulation of mesencepahalic cell proliferation http://purl.obolibrary.org/obo/GO_1904933 GO:0047118 biolink:MolecularActivity 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH. EC:1.3.1.40|KEGG_REACTION:R03463|MetaCyc:1.3.1.40-RXN|RHEA:24268 go.json 2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity|2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity http://purl.obolibrary.org/obo/GO_0047118 GO:1904932 biolink:BiologicalProcess negative regulation of cartilage condensation Any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation. go.json down regulation of cartilage condensation|down-regulation of cartilage condensation|downregulation of cartilage condensation|inhibition of cartilage condensation http://purl.obolibrary.org/obo/GO_1904932 GO:0047117 biolink:MolecularActivity enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+. EC:1.3.1.39|MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN go.json acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)|enoyl-ACP reductase (NADPH, A-specific) activity|enoyl-ACp reductase activity|enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity|enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|enoyl-acyl-carrier-protein reductase (NADPH, A-specific) http://purl.obolibrary.org/obo/GO_0047117 GO:0047116 biolink:MolecularActivity 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol. EC:1.3.1.25|MetaCyc:1.3.1.25-RXN|RHEA:11560 go.json (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)|2-hydro-1,2-dihydroxybenzoate dehydrogenase activity|3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity|3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity|DHB dehydrogenase activity|DHBDH activity|cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity|cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity|dihydrodihydroxybenzoate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047116 GO:1904931 biolink:MolecularActivity MCM complex binding Binding to an MCM complex. go.json mini-chromosome maintenance complex binding http://purl.obolibrary.org/obo/GO_1904931 GO:1904930 biolink:CellularComponent amphisome membrane Any membrane that is part of an amphisome. go.json http://purl.obolibrary.org/obo/GO_1904930 GO:0047115 biolink:MolecularActivity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. EC:1.3.1.20|MetaCyc:1.3.1.20-RXN|RHEA:16729 go.json dihydrodiol dehydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047115 GO:0047114 biolink:MolecularActivity kynurenate-7,8-dihydrodiol dehydrogenase activity Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH. EC:1.3.1.18|KEGG_REACTION:R03251|MetaCyc:1.3.1.18-RXN|RHEA:22248 go.json 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity|7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity|7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047114 GO:0047113 biolink:MolecularActivity aldehyde dehydrogenase (quinone) activity Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol. EC:1.2.5.2|MetaCyc:1.2.99.3-RXN|RHEA:13881 go.json aldehyde dehydrogenase (acceptor) activity|aldehyde dehydrogenase (pyrroloquinoline-quinone)|aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047113 GO:0047112 biolink:MolecularActivity pyruvate oxidase activity Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2. EC:1.2.3.3|KEGG_REACTION:R00207|MetaCyc:1.2.3.3-RXN|RHEA:20848 go.json phosphate-dependent pyruvate oxidase activity|pyruvate:oxygen 2-oxidoreductase (phosphorylating)|pyruvic oxidase activity http://purl.obolibrary.org/obo/GO_0047112 GO:0047122 biolink:MolecularActivity quinaldate 4-oxidoreductase activity Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate. EC:1.3.99.18|KEGG_REACTION:R03687|MetaCyc:1.3.99.18-RXN|RHEA:16697 go.json quinaldic acid 4-oxidoreductase activity|quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0047122 GO:0047121 biolink:MolecularActivity isoquinoline 1-oxidoreductase activity Catalysis of the reaction: A + H2O + isoquinoline = AH(2) + isoquinolin-1(2H)-one. EC:1.3.99.16|KEGG_REACTION:R05151|MetaCyc:1.3.99.16-RXN|RHEA:11588 go.json isoquinoline:acceptor 1-oxidoreductase (hydroxylating) http://purl.obolibrary.org/obo/GO_0047121 GO:0047120 biolink:MolecularActivity (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH. EC:1.3.1.53|KEGG_REACTION:R01633|MetaCyc:1.3.1.53-RXN|RHEA:10744|UM-BBD_reactionID:r0151 go.json (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity|(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity|cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)|dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity|terephthalate 1,2-cis-dihydrodiol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047120 GO:1904949 biolink:CellularComponent ATPase complex A protein complex which is capable of ATPase activity. go.json VPS4 complex http://purl.obolibrary.org/obo/GO_1904949 GO:1904948 biolink:BiologicalProcess midbrain dopaminergic neuron differentiation The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron. go.json DA neurogenesis from midbrain floor plate|mDA neuron differentiation|midbrain DA neurogenesis|midbrain dopaminergic neuron production http://purl.obolibrary.org/obo/GO_1904948 GO:1904947 biolink:BiologicalProcess folate import into mitochondrion The process in which folic acid is transported from the cytosol into the mitochondrial matrix. go.json folic acid import into mitochondrion http://purl.obolibrary.org/obo/GO_1904947 GO:1904946 biolink:BiologicalProcess obsolete cellular response to cobalt(II) acetate OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904946 GO:1904945 biolink:BiologicalProcess obsolete response to cobalt(II) acetate OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904945 GO:0047129 biolink:MolecularActivity opine dehydrogenase activity Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD+ = L-2-aminopentanoate + H+ + NADH + pyruvate. EC:1.5.1.28|KEGG_REACTION:R03732|MetaCyc:1.5.1.28-RXN|RHEA:21592 go.json (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)|(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming) http://purl.obolibrary.org/obo/GO_0047129 GO:1904944 biolink:BiologicalProcess positive regulation of cardiac ventricle formation Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. go.json activation of cardiac ventricle formation|up regulation of cardiac ventricle formation|up-regulation of cardiac ventricle formation|upregulation of cardiac ventricle formation http://purl.obolibrary.org/obo/GO_1904944 GO:0047128 biolink:MolecularActivity 1,2-dehydroreticulinium reductase (NADPH) activity Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH. EC:1.5.1.27|KEGG_REACTION:R04695|MetaCyc:1.5.1.27-RXN|RHEA:17569 go.json (R)-reticuline:NADP+ oxidoreductase activity|1,2-dehydroreticulinium ion reductase activity http://purl.obolibrary.org/obo/GO_0047128 GO:1904943 biolink:BiologicalProcess negative regulation of cardiac ventricle formation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. go.json down regulation of cardiac ventricle formation|down-regulation of cardiac ventricle formation|downregulation of cardiac ventricle formation|inhibition of cardiac ventricle formation http://purl.obolibrary.org/obo/GO_1904943 GO:0047127 biolink:MolecularActivity thiomorpholine-carboxylate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate. EC:1.5.1.25|MetaCyc:1.5.1.25-RXN|Reactome:R-HSA-5693347 go.json ketimine reductase activity|ketimine-reducing enzyme|thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047127 GO:1904942 biolink:BiologicalProcess regulation of cardiac ventricle formation Any process that modulates the frequency, rate or extent of cardiac ventricle formation. go.json http://purl.obolibrary.org/obo/GO_1904942 GO:1904941 biolink:BiologicalProcess obsolete positive regulation of DNA nucleotidylexotransferase activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA nucleotidylexotransferase activity. go.json activation of DNA nucleotidylexotransferase activity|activation of TdT|activation of addase activity|activation of deoxynucleotidyl terminal transferase activity|activation of deoxyribonucleic acid nucleotidyltransferase activity|activation of deoxyribonucleic nucleotidyltransferase activity|activation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|activation of terminal addition enzyme activity|activation of terminal deoxynucleotide transferase activity|activation of terminal deoxynucleotidyltransferase activity|activation of terminal deoxyribonucleotidyltransferase activity|activation of terminal transferase activity|positive regulation of TdT|positive regulation of addase activity|positive regulation of deoxynucleotidyl terminal transferase activity|positive regulation of deoxyribonucleic acid nucleotidyltransferase activity|positive regulation of deoxyribonucleic nucleotidyltransferase activity|positive regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|positive regulation of terminal addition enzyme activity|positive regulation of terminal deoxynucleotide transferase activity|positive regulation of terminal deoxynucleotidyltransferase activity|positive regulation of terminal deoxyribonucleotidyltransferase activity|positive regulation of terminal transferase activity|up regulation of DNA nucleotidylexotransferase activity|up regulation of TdT|up regulation of addase activity|up regulation of deoxynucleotidyl terminal transferase activity|up regulation of deoxyribonucleic acid nucleotidyltransferase activity|up regulation of deoxyribonucleic nucleotidyltransferase activity|up regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|up regulation of terminal addition enzyme activity|up regulation of terminal deoxynucleotide transferase activity|up regulation of terminal deoxynucleotidyltransferase activity|up regulation of terminal deoxyribonucleotidyltransferase activity|up regulation of terminal transferase activity|up-regulation of DNA nucleotidylexotransferase activity|up-regulation of TdT|up-regulation of addase activity|up-regulation of deoxynucleotidyl terminal transferase activity|up-regulation of deoxyribonucleic acid nucleotidyltransferase activity|up-regulation of deoxyribonucleic nucleotidyltransferase activity|up-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|up-regulation of terminal addition enzyme activity|up-regulation of terminal deoxynucleotide transferase activity|up-regulation of terminal deoxynucleotidyltransferase activity|up-regulation of terminal deoxyribonucleotidyltransferase activity|up-regulation of terminal transferase activity|upregulation of DNA nucleotidylexotransferase activity|upregulation of TdT|upregulation of addase activity|upregulation of deoxynucleotidyl terminal transferase activity|upregulation of deoxyribonucleic acid nucleotidyltransferase activity|upregulation of deoxyribonucleic nucleotidyltransferase activity|upregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|upregulation of terminal addition enzyme activity|upregulation of terminal deoxynucleotide transferase activity|upregulation of terminal deoxynucleotidyltransferase activity|upregulation of terminal deoxyribonucleotidyltransferase activity|upregulation of terminal transferase activity True http://purl.obolibrary.org/obo/GO_1904941 GO:0047126 biolink:MolecularActivity N5-(carboxyethyl)ornithine synthase activity Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H2O + NADP+ = L-ornithine + H+ + NADPH + pyruvate. EC:1.5.1.24|KEGG_REACTION:R00666|MetaCyc:1.5.1.24-RXN|RHEA:18661 go.json 5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)|N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming) http://purl.obolibrary.org/obo/GO_0047126 GO:1904940 biolink:BiologicalProcess obsolete negative regulation of DNA nucleotidylexotransferase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA nucleotidylexotransferase activity. go.json down regulation of DNA nucleotidylexotransferase activity|down regulation of TdT|down regulation of addase activity|down regulation of deoxynucleotidyl terminal transferase activity|down regulation of deoxyribonucleic acid nucleotidyltransferase activity|down regulation of deoxyribonucleic nucleotidyltransferase activity|down regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|down regulation of terminal addition enzyme activity|down regulation of terminal deoxynucleotide transferase activity|down regulation of terminal deoxynucleotidyltransferase activity|down regulation of terminal deoxyribonucleotidyltransferase activity|down regulation of terminal transferase activity|down-regulation of DNA nucleotidylexotransferase activity|down-regulation of TdT|down-regulation of addase activity|down-regulation of deoxynucleotidyl terminal transferase activity|down-regulation of deoxyribonucleic acid nucleotidyltransferase activity|down-regulation of deoxyribonucleic nucleotidyltransferase activity|down-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|down-regulation of terminal addition enzyme activity|down-regulation of terminal deoxynucleotide transferase activity|down-regulation of terminal deoxynucleotidyltransferase activity|down-regulation of terminal deoxyribonucleotidyltransferase activity|down-regulation of terminal transferase activity|downregulation of DNA nucleotidylexotransferase activity|downregulation of TdT|downregulation of addase activity|downregulation of deoxynucleotidyl terminal transferase activity|downregulation of deoxyribonucleic acid nucleotidyltransferase activity|downregulation of deoxyribonucleic nucleotidyltransferase activity|downregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|downregulation of terminal addition enzyme activity|downregulation of terminal deoxynucleotide transferase activity|downregulation of terminal deoxynucleotidyltransferase activity|downregulation of terminal deoxyribonucleotidyltransferase activity|downregulation of terminal transferase activity|inhibition of DNA nucleotidylexotransferase activity|inhibition of TdT|inhibition of addase activity|inhibition of deoxynucleotidyl terminal transferase activity|inhibition of deoxyribonucleic acid nucleotidyltransferase activity|inhibition of deoxyribonucleic nucleotidyltransferase activity|inhibition of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|inhibition of terminal addition enzyme activity|inhibition of terminal deoxynucleotide transferase activity|inhibition of terminal deoxynucleotidyltransferase activity|inhibition of terminal deoxyribonucleotidyltransferase activity|inhibition of terminal transferase activity|negative regulation of TdT|negative regulation of addase activity|negative regulation of deoxynucleotidyl terminal transferase activity|negative regulation of deoxyribonucleic acid nucleotidyltransferase activity|negative regulation of deoxyribonucleic nucleotidyltransferase activity|negative regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|negative regulation of terminal addition enzyme activity|negative regulation of terminal deoxynucleotide transferase activity|negative regulation of terminal deoxynucleotidyltransferase activity|negative regulation of terminal deoxyribonucleotidyltransferase activity|negative regulation of terminal transferase activity True http://purl.obolibrary.org/obo/GO_1904940 GO:0047125 biolink:MolecularActivity delta1-piperideine-2-carboxylate reductase activity Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate. EC:1.5.1.21|MetaCyc:RXN-8166|RHEA:12524 go.json 1,2-didehydropipecolate reductase activity|1,2-didehydropipecolic reductase activity|D1-piperideine-2-carboxylate reductase activity|L-pipecolate:NADP+ 2-oxidoreductase activity|P2C reductase activity|delta 1-piperideine-2-carboxylate reductase activity http://purl.obolibrary.org/obo/GO_0047125 GO:0047124 biolink:MolecularActivity L-erythro-3,5-diaminohexanoate dehydrogenase activity Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4. EC:1.4.1.11|KEGG_REACTION:R03349|MetaCyc:1.4.1.11-RXN|RHEA:19633 go.json L-3,5-diaminohexanoate dehydrogenase activity|L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0047124 GO:0047123 biolink:MolecularActivity quinoline-4-carboxylate 2-oxidoreductase activity Catalysis of the reaction: A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2). EC:1.3.99.19|KEGG_REACTION:R05183|MetaCyc:1.3.99.19-RXN|RHEA:14949 go.json quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)|quinoline-4-carboxylic acid 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0047123 GO:0106199 biolink:MolecularActivity obsolete translocase activity acting on amino acids and peptides linked to oxidoreductase reactions OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to oxidoreductase reactions. EC:7.4.1.- go.json True http://purl.obolibrary.org/obo/GO_0106199 GO:0106198 biolink:MolecularActivity obsolete translocase activity acting on inorganic anions linked to a decarboxylation reaction OBSOLETE. Catalysis of the translocation of an inorganic anion linked to a decarboxylation reaction. EC:7.3.4.- go.json True http://purl.obolibrary.org/obo/GO_0106198 GO:0106197 biolink:MolecularActivity obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a diphosphate OBSOLETE. Catalysis of the translocation of inorganic anions llinked to the hydrolysis of a diphosphate. EC:7.3.3.- go.json True http://purl.obolibrary.org/obo/GO_0106197 GO:0106196 biolink:MolecularActivity obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a nucleoside triphosphate OBSOLETE. Catalysis of the translocation of inorganic anions linked to the hydrolysis of a nucleoside triphosphate. EC:7.3.2.- go.json True http://purl.obolibrary.org/obo/GO_0106196 GO:0072298 biolink:BiologicalProcess regulation of metanephric glomerulus development Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. go.json http://purl.obolibrary.org/obo/GO_0072298 GO:0072297 biolink:BiologicalProcess specification of metanephric proximal tubule identity The process in which the proximal tubule of the metanephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072297 GO:0072296 biolink:BiologicalProcess specification of metanephric loop of Henle identity The process in which the loop of Henle of the metanephric nephron acquires its identity. go.json specification of metanephric intermediate tubule identity http://purl.obolibrary.org/obo/GO_0072296 GO:0072295 biolink:BiologicalProcess specification of metanephric distal tubule identity The process in which the distal tubule of the metanephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072295 GO:0072294 biolink:BiologicalProcess specification of metanephric connecting tubule identity The process in which the connecting tubule of the metanephric nephron acquires its identity. go.json http://purl.obolibrary.org/obo/GO_0072294 GO:0072293 biolink:BiologicalProcess specification of metanephric nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity. go.json http://purl.obolibrary.org/obo/GO_0072293 GO:0072292 biolink:BiologicalProcess epithelial cell migration involved in metanephric proximal tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0072292 GO:0072291 biolink:BiologicalProcess epithelial cell migration involved in metanephric distal tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0072291 GO:0072290 biolink:BiologicalProcess epithelial cell migration involved in metanephric nephron tubule morphogenesis The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis. go.json http://purl.obolibrary.org/obo/GO_0072290 GO:1900077 biolink:BiologicalProcess negative regulation of cellular response to insulin stimulus Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. go.json down regulation of cellular response to insulin stimulus|down-regulation of cellular response to insulin stimulus|downregulation of cellular response to insulin stimulus|inhibition of cellular response to insulin stimulus http://purl.obolibrary.org/obo/GO_1900077 GO:1900076 biolink:BiologicalProcess regulation of cellular response to insulin stimulus Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. go.json http://purl.obolibrary.org/obo/GO_1900076 GO:1900079 biolink:BiologicalProcess regulation of arginine biosynthetic process Any process that modulates the frequency, rate or extent of arginine biosynthetic process. go.json regulation of arginine anabolism|regulation of arginine biosynthesis|regulation of arginine formation|regulation of arginine synthesis http://purl.obolibrary.org/obo/GO_1900079 GO:1900078 biolink:BiologicalProcess positive regulation of cellular response to insulin stimulus Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. go.json activation of cellular response to insulin stimulus|up regulation of cellular response to insulin stimulus|up-regulation of cellular response to insulin stimulus|upregulation of cellular response to insulin stimulus http://purl.obolibrary.org/obo/GO_1900078 GO:1900084 biolink:BiologicalProcess regulation of peptidyl-tyrosine autophosphorylation Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation. go.json regulation of receptor tyrosine kinase autophosphorylation|regulation of tyrosine autophosphorylation http://purl.obolibrary.org/obo/GO_1900084 GO:1900083 biolink:BiologicalProcess obsolete regulation of Sertoli cell proliferation OBSOLETE. Any process that modulates the frequency, rate or extent of Sertoli cell proliferation. go.json regulation of Sertoli cell proliferation True http://purl.obolibrary.org/obo/GO_1900083 GO:1900086 biolink:BiologicalProcess positive regulation of peptidyl-tyrosine autophosphorylation Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation. go.json activation of peptidyl-tyrosine autophosphorylation|activation of receptor tyrosine kinase autophosphorylation|activation of tyrosine autophosphorylation|positive regulation of receptor tyrosine kinase autophosphorylation|positive regulation of tyrosine autophosphorylation|up regulation of peptidyl-tyrosine autophosphorylation|up regulation of receptor tyrosine kinase autophosphorylation|up regulation of tyrosine autophosphorylation|up-regulation of peptidyl-tyrosine autophosphorylation|up-regulation of receptor tyrosine kinase autophosphorylation|up-regulation of tyrosine autophosphorylation|upregulation of peptidyl-tyrosine autophosphorylation|upregulation of receptor tyrosine kinase autophosphorylation|upregulation of tyrosine autophosphorylation http://purl.obolibrary.org/obo/GO_1900086 GO:1900085 biolink:BiologicalProcess negative regulation of peptidyl-tyrosine autophosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation. go.json down regulation of peptidyl-tyrosine autophosphorylation|down regulation of receptor tyrosine kinase autophosphorylation|down regulation of tyrosine autophosphorylation|down-regulation of peptidyl-tyrosine autophosphorylation|down-regulation of receptor tyrosine kinase autophosphorylation|down-regulation of tyrosine autophosphorylation|downregulation of peptidyl-tyrosine autophosphorylation|downregulation of receptor tyrosine kinase autophosphorylation|downregulation of tyrosine autophosphorylation|inhibition of peptidyl-tyrosine autophosphorylation|inhibition of receptor tyrosine kinase autophosphorylation|inhibition of tyrosine autophosphorylation|negative regulation of receptor tyrosine kinase autophosphorylation|negative regulation of tyrosine autophosphorylation http://purl.obolibrary.org/obo/GO_1900085 GO:1900080 biolink:BiologicalProcess positive regulation of arginine biosynthetic process Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process. go.json activation of arginine anabolism|activation of arginine biosynthesis|activation of arginine biosynthetic process|activation of arginine formation|activation of arginine synthesis|positive regulation of arginine anabolism|positive regulation of arginine biosynthesis|positive regulation of arginine formation|positive regulation of arginine synthesis|up regulation of arginine anabolism|up regulation of arginine biosynthesis|up regulation of arginine biosynthetic process|up regulation of arginine formation|up regulation of arginine synthesis|up-regulation of arginine anabolism|up-regulation of arginine biosynthesis|up-regulation of arginine biosynthetic process|up-regulation of arginine formation|up-regulation of arginine synthesis|upregulation of arginine anabolism|upregulation of arginine biosynthesis|upregulation of arginine biosynthetic process|upregulation of arginine formation|upregulation of arginine synthesis http://purl.obolibrary.org/obo/GO_1900080 GO:1900082 biolink:BiologicalProcess negative regulation of arginine catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process. go.json down regulation of arginine breakdown|down regulation of arginine catabolic process|down regulation of arginine catabolism|down regulation of arginine degradation|down-regulation of arginine breakdown|down-regulation of arginine catabolic process|down-regulation of arginine catabolism|down-regulation of arginine degradation|downregulation of arginine breakdown|downregulation of arginine catabolic process|downregulation of arginine catabolism|downregulation of arginine degradation|inhibition of arginine breakdown|inhibition of arginine catabolic process|inhibition of arginine catabolism|inhibition of arginine degradation|negative regulation of arginine breakdown|negative regulation of arginine catabolism|negative regulation of arginine degradation http://purl.obolibrary.org/obo/GO_1900082 GO:1900081 biolink:BiologicalProcess regulation of arginine catabolic process Any process that modulates the frequency, rate or extent of arginine catabolic process. go.json regulation of arginine breakdown|regulation of arginine catabolism|regulation of arginine degradation http://purl.obolibrary.org/obo/GO_1900081 GO:0072299 biolink:BiologicalProcess negative regulation of metanephric glomerulus development Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. go.json http://purl.obolibrary.org/obo/GO_0072299 GO:0072287 biolink:BiologicalProcess metanephric distal tubule morphogenesis The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule. go.json http://purl.obolibrary.org/obo/GO_0072287 GO:0072286 biolink:BiologicalProcess metanephric connecting tubule development The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros. go.json metanephric connecting duct development http://purl.obolibrary.org/obo/GO_0072286 GO:0072285 biolink:BiologicalProcess mesenchymal to epithelial transition involved in metanephric renal vesicle formation A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle. go.json http://purl.obolibrary.org/obo/GO_0072285 GO:0072284 biolink:BiologicalProcess metanephric S-shaped body morphogenesis The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072284 GO:0072283 biolink:BiologicalProcess metanephric renal vesicle morphogenesis The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072283 GO:0072282 biolink:BiologicalProcess metanephric nephron tubule morphogenesis The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072282 GO:0072281 biolink:BiologicalProcess mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072281 GO:0072280 biolink:BiologicalProcess establishment of planar polarity involved in metanephric nephron morphogenesis Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros. go.json establishment of planar cell polarity involved in metanephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072280 GO:1900088 biolink:BiologicalProcess regulation of inositol biosynthetic process Any process that modulates the frequency, rate or extent of inositol biosynthetic process. go.json regulation of inositol anabolism|regulation of inositol biosynthesis|regulation of inositol formation|regulation of inositol synthesis|regulation of myo-inositol biosynthesis|regulation of myo-inositol biosynthetic process|regulation of vitamin Bh biosynthesis|regulation of vitamin Bh biosynthetic process http://purl.obolibrary.org/obo/GO_1900088 GO:1900087 biolink:BiologicalProcess positive regulation of G1/S transition of mitotic cell cycle Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. go.json activation of G1/S transition of mitotic cell cycle|up regulation of G1/S transition of mitotic cell cycle|up-regulation of G1/S transition of mitotic cell cycle|upregulation of G1/S transition of mitotic cell cycle http://purl.obolibrary.org/obo/GO_1900087 GO:1900089 biolink:BiologicalProcess negative regulation of inositol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process. go.json down regulation of inositol anabolism|down regulation of inositol biosynthesis|down regulation of inositol biosynthetic process|down regulation of inositol formation|down regulation of inositol synthesis|down regulation of myo-inositol biosynthesis|down regulation of myo-inositol biosynthetic process|down regulation of vitamin Bh biosynthesis|down regulation of vitamin Bh biosynthetic process|down-regulation of inositol anabolism|down-regulation of inositol biosynthesis|down-regulation of inositol biosynthetic process|down-regulation of inositol formation|down-regulation of inositol synthesis|down-regulation of myo-inositol biosynthesis|down-regulation of myo-inositol biosynthetic process|down-regulation of vitamin Bh biosynthesis|down-regulation of vitamin Bh biosynthetic process|downregulation of inositol anabolism|downregulation of inositol biosynthesis|downregulation of inositol biosynthetic process|downregulation of inositol formation|downregulation of inositol synthesis|downregulation of myo-inositol biosynthesis|downregulation of myo-inositol biosynthetic process|downregulation of vitamin Bh biosynthesis|downregulation of vitamin Bh biosynthetic process|inhibition of inositol anabolism|inhibition of inositol biosynthesis|inhibition of inositol biosynthetic process|inhibition of inositol formation|inhibition of inositol synthesis|inhibition of myo-inositol biosynthesis|inhibition of myo-inositol biosynthetic process|inhibition of vitamin Bh biosynthesis|inhibition of vitamin Bh biosynthetic process|negative regulation of inositol anabolism|negative regulation of inositol biosynthesis|negative regulation of inositol formation|negative regulation of inositol synthesis|negative regulation of myo-inositol biosynthesis|negative regulation of myo-inositol biosynthetic process|negative regulation of vitamin Bh biosynthesis|negative regulation of vitamin Bh biosynthetic process http://purl.obolibrary.org/obo/GO_1900089 GO:1900095 biolink:BiologicalProcess obsolete regulation of dosage compensation by inactivation of X chromosome OBSOLETE. Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. go.json regulation of Barr body formation|regulation of X chromosome inactivation|regulation of chromosome inactivation True http://purl.obolibrary.org/obo/GO_1900095 GO:1900094 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry. go.json global transcription regulation from Pol II promoter of determination of left/right asymmetry|global transcription regulation from Pol II promoter of determination of left/right symmetry|regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry|regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry|regulation of global transcription from Pol II promoter of determination of left/right asymmetry|regulation of global transcription from Pol II promoter of determination of left/right symmetry|regulation of transcription from Pol II promoter of determination of left/right asymmetry|regulation of transcription from Pol II promoter of determination of left/right symmetry|regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry|regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry|regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry|regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry True http://purl.obolibrary.org/obo/GO_1900094 GO:1900097 biolink:BiologicalProcess obsolete positive regulation of dosage compensation by inactivation of X chromosome OBSOLETE. Any process that activates or increases the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. go.json activation of Barr body formation|activation of X chromosome inactivation|activation of chromosome inactivation|activation of dosage compensation, by inactivation of X chromosome|positive regulation of Barr body formation|positive regulation of X chromosome inactivation|positive regulation of chromosome inactivation|up regulation of Barr body formation|up regulation of X chromosome inactivation|up regulation of chromosome inactivation|up regulation of dosage compensation, by inactivation of X chromosome|up-regulation of Barr body formation|up-regulation of X chromosome inactivation|up-regulation of chromosome inactivation|up-regulation of dosage compensation, by inactivation of X chromosome|upregulation of Barr body formation|upregulation of X chromosome inactivation|upregulation of chromosome inactivation|upregulation of dosage compensation, by inactivation of X chromosome True http://purl.obolibrary.org/obo/GO_1900097 GO:1900096 biolink:BiologicalProcess obsolete negative regulation of dosage compensation by inactivation of X chromosome OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. go.json down regulation of Barr body formation|down regulation of X chromosome inactivation|down regulation of chromosome inactivation|down regulation of dosage compensation, by inactivation of X chromosome|down-regulation of Barr body formation|down-regulation of X chromosome inactivation|down-regulation of chromosome inactivation|down-regulation of dosage compensation, by inactivation of X chromosome|downregulation of Barr body formation|downregulation of X chromosome inactivation|downregulation of chromosome inactivation|downregulation of dosage compensation, by inactivation of X chromosome|inhibition of Barr body formation|inhibition of X chromosome inactivation|inhibition of chromosome inactivation|inhibition of dosage compensation, by inactivation of X chromosome|negative regulation of Barr body formation|negative regulation of X chromosome inactivation|negative regulation of chromosome inactivation True http://purl.obolibrary.org/obo/GO_1900096 GO:1900091 biolink:BiologicalProcess regulation of raffinose biosynthetic process Any process that modulates the frequency, rate or extent of raffinose biosynthetic process. go.json regulation of raffinose anabolism|regulation of raffinose biosynthesis|regulation of raffinose formation|regulation of raffinose synthesis http://purl.obolibrary.org/obo/GO_1900091 GO:1900090 biolink:BiologicalProcess positive regulation of inositol biosynthetic process Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process. go.json activation of inositol anabolism|activation of inositol biosynthesis|activation of inositol biosynthetic process|activation of inositol formation|activation of inositol synthesis|activation of myo-inositol biosynthesis|activation of myo-inositol biosynthetic process|activation of vitamin Bh biosynthesis|activation of vitamin Bh biosynthetic process|positive regulation of inositol anabolism|positive regulation of inositol biosynthesis|positive regulation of inositol formation|positive regulation of inositol synthesis|positive regulation of myo-inositol biosynthesis|positive regulation of myo-inositol biosynthetic process|positive regulation of vitamin Bh biosynthesis|positive regulation of vitamin Bh biosynthetic process|up regulation of inositol anabolism|up regulation of inositol biosynthesis|up regulation of inositol biosynthetic process|up regulation of inositol formation|up regulation of inositol synthesis|up regulation of myo-inositol biosynthesis|up regulation of myo-inositol biosynthetic process|up regulation of vitamin Bh biosynthesis|up regulation of vitamin Bh biosynthetic process|up-regulation of inositol anabolism|up-regulation of inositol biosynthesis|up-regulation of inositol biosynthetic process|up-regulation of inositol formation|up-regulation of inositol synthesis|up-regulation of myo-inositol biosynthesis|up-regulation of myo-inositol biosynthetic process|up-regulation of vitamin Bh biosynthesis|up-regulation of vitamin Bh biosynthetic process|upregulation of inositol anabolism|upregulation of inositol biosynthesis|upregulation of inositol biosynthetic process|upregulation of inositol formation|upregulation of inositol synthesis|upregulation of myo-inositol biosynthesis|upregulation of myo-inositol biosynthetic process|upregulation of vitamin Bh biosynthesis|upregulation of vitamin Bh biosynthetic process http://purl.obolibrary.org/obo/GO_1900090 GO:1900093 biolink:BiologicalProcess positive regulation of raffinose biosynthetic process Any process that activates or increases the frequency, rate or extent of raffinose biosynthetic process. go.json activation of raffinose anabolism|activation of raffinose biosynthesis|activation of raffinose biosynthetic process|activation of raffinose formation|activation of raffinose synthesis|positive regulation of raffinose anabolism|positive regulation of raffinose biosynthesis|positive regulation of raffinose formation|positive regulation of raffinose synthesis|up regulation of raffinose anabolism|up regulation of raffinose biosynthesis|up regulation of raffinose biosynthetic process|up regulation of raffinose formation|up regulation of raffinose synthesis|up-regulation of raffinose anabolism|up-regulation of raffinose biosynthesis|up-regulation of raffinose biosynthetic process|up-regulation of raffinose formation|up-regulation of raffinose synthesis|upregulation of raffinose anabolism|upregulation of raffinose biosynthesis|upregulation of raffinose biosynthetic process|upregulation of raffinose formation|upregulation of raffinose synthesis http://purl.obolibrary.org/obo/GO_1900093 GO:1900092 biolink:BiologicalProcess negative regulation of raffinose biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process. go.json down regulation of raffinose anabolism|down regulation of raffinose biosynthesis|down regulation of raffinose biosynthetic process|down regulation of raffinose formation|down regulation of raffinose synthesis|down-regulation of raffinose anabolism|down-regulation of raffinose biosynthesis|down-regulation of raffinose biosynthetic process|down-regulation of raffinose formation|down-regulation of raffinose synthesis|downregulation of raffinose anabolism|downregulation of raffinose biosynthesis|downregulation of raffinose biosynthetic process|downregulation of raffinose formation|downregulation of raffinose synthesis|inhibition of raffinose anabolism|inhibition of raffinose biosynthesis|inhibition of raffinose biosynthetic process|inhibition of raffinose formation|inhibition of raffinose synthesis|negative regulation of raffinose anabolism|negative regulation of raffinose biosynthesis|negative regulation of raffinose formation|negative regulation of raffinose synthesis http://purl.obolibrary.org/obo/GO_1900092 GO:0072289 biolink:BiologicalProcess metanephric nephron tubule formation The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072289 GO:0072288 biolink:BiologicalProcess metanephric proximal tubule morphogenesis The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. go.json http://purl.obolibrary.org/obo/GO_0072288 GO:1900099 biolink:BiologicalProcess negative regulation of plasma cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation. go.json down regulation of plasma cell development|down regulation of plasma cell differentiation|down-regulation of plasma cell development|down-regulation of plasma cell differentiation|downregulation of plasma cell development|downregulation of plasma cell differentiation|inhibition of plasma cell development|inhibition of plasma cell differentiation|negative regulation of plasma cell development http://purl.obolibrary.org/obo/GO_1900099 GO:1900098 biolink:BiologicalProcess regulation of plasma cell differentiation Any process that modulates the frequency, rate or extent of plasma cell differentiation. go.json regulation of plasma cell development http://purl.obolibrary.org/obo/GO_1900098 GO:0072210 biolink:BiologicalProcess metanephric nephron development The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. go.json http://purl.obolibrary.org/obo/GO_0072210 GO:0047254 biolink:MolecularActivity 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP. EC:2.4.1.202|MetaCyc:RXN-7022|RHEA:15541 go.json UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity|UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity|uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047254 GO:0047253 biolink:MolecularActivity alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP. EC:2.4.1.201|MetaCyc:2.4.1.201-RXN|RHEA:19945 go.json N-acetylglucosaminyltransferase VI activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity|UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity|mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI|uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity http://purl.obolibrary.org/obo/GO_0047253 GO:0047252 biolink:MolecularActivity beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate. EC:2.4.1.199|MetaCyc:2.4.1.199-RXN go.json beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity|mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0047252 GO:0047251 biolink:MolecularActivity thiohydroximate beta-D-glucosyltransferase activity Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP. EC:2.4.1.195|MetaCyc:2.4.1.195-RXN|RHEA:13757 go.json N-hydroxythioamide S-beta-glucosyltransferase activity|UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity|UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity|UDPG:thiohydroximate glucosyltransferase activity|desulfoglucosinolate-uridine diphosphate glucosyltransferase activity|thiohydroximate S-glucosyltransferase activity|thiohydroximate glucosyltransferase activity|uridine diphosphoglucose-thiohydroximate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047251 GO:0047250 biolink:MolecularActivity 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H+ + UDP. EC:2.4.1.194|KEGG_REACTION:R01304|MetaCyc:2.4.1.194-RXN|RHEA:15153 go.json HBA glucosyltransferase activity|PHB glucosyltransferase activity|PHB-O-glucosyltransferase activity|UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity|UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity|UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity|p-hydroxybenzoate glucosyltransferase activity|uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047250 GO:0047259 biolink:MolecularActivity glucomannan 4-beta-mannosyltransferase activity Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP. EC:2.4.1.32|MetaCyc:2.4.1.32-RXN go.json GDP-man-beta-mannan mannosyltransferase activity|GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity|glucomannan 4-b-mannosyltransferase activity|glucomannan-synthase activity http://purl.obolibrary.org/obo/GO_0047259 GO:0047258 biolink:MolecularActivity sphingosine beta-galactosyltransferase activity Catalysis of the reaction: sphingosine + UDP-D-galactose = H+ + psychosine + UDP. EC:2.4.1.23|KEGG_REACTION:R01928|MetaCyc:2.4.1.23-RXN|RHEA:19485 go.json UDP-galactose:sphingosine 1-beta-galactotransferase activity|UDPgalactose:sphingosine 1-beta-galactotransferase activity|UDPgalactose:sphingosine O-galactosyl transferase activity|galactosyl-sphingosine transferase activity|psychosine-UDP galactosyltransferase activity|psychosine-uridine diphosphate galactosyltransferase activity|uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047258 GO:0047257 biolink:MolecularActivity diglucosyl diacylglycerol synthase activity Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol. EC:2.4.1.208|MetaCyc:2.4.1.208-RXN|RHEA:19165 go.json DGlcDAG synthase activity|MGlcDAG (1->2) glucosyltransferase activity|UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity|diglucosyl diacylglycerol (DGlcDAG) synthase activity|monoglucosyl diacylglycerol (1->2) glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047257 GO:0047256 biolink:MolecularActivity lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. EC:2.4.1.206|MetaCyc:2.4.1.206-RXN|RHEA:13905 go.json LA2 synthase activity|UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity|beta1->3-N-acetylglucosaminyltransferase activity|lactosylceramide beta-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047256 GO:0047255 biolink:MolecularActivity galactogen 6-beta-galactosyltransferase activity Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP. EC:2.4.1.205|MetaCyc:2.4.1.205-RXN go.json 1,6-D-galactosyltransferase activity|UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity|UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity|beta-(1,6)-D-galactosyltransferase activity|galactogen 6beta-galactosyltransferase activity|uridine diphosphogalactose-galactogen galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047255 GO:0072219 biolink:BiologicalProcess metanephric cortical collecting duct development The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex. go.json http://purl.obolibrary.org/obo/GO_0072219 GO:0072218 biolink:BiologicalProcess metanephric ascending thin limb development The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent. go.json http://purl.obolibrary.org/obo/GO_0072218 GO:0072217 biolink:BiologicalProcess negative regulation of metanephros development Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0072217 GO:0072216 biolink:BiologicalProcess positive regulation of metanephros development Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0072216 GO:0072215 biolink:BiologicalProcess regulation of metanephros development Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. go.json http://purl.obolibrary.org/obo/GO_0072215 GO:0072214 biolink:BiologicalProcess metanephric cortex development The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072214 GO:0072213 biolink:BiologicalProcess metanephric capsule development The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. go.json http://purl.obolibrary.org/obo/GO_0072213 GO:0072212 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in metanephros development OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the metanephros progresses from its initial formation to the mature state. go.json True http://purl.obolibrary.org/obo/GO_0072212 GO:0072211 biolink:BiologicalProcess metanephric pyramids development The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts. go.json metanephric kidney pyramid development|metanephric pyramid development|metanephric renal medulla development|metanephric renal pyramid development http://purl.obolibrary.org/obo/GO_0072211 GO:0047265 biolink:MolecularActivity poly(glycerol-phosphate) alpha-glucosyltransferase activity Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP. EC:2.4.1.52|MetaCyc:TEICHOICSYN5-RXN|RHEA:15845 go.json UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity|UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity|UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity|uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047265 GO:0047264 biolink:MolecularActivity heteroglycan alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP. EC:2.4.1.48 go.json GDP mannose alpha-mannosyltransferase activity|GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity|guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity|heteropolysaccharide alpha-mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0047264 GO:0047263 biolink:MolecularActivity N-acylsphingosine galactosyltransferase activity Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP. EC:2.4.1.47|MetaCyc:2.4.1.47-RXN|RHEA:13093|Reactome:R-HSA-6785933 go.json UDP galactose-N-acylsphingosine galactosyltransferase activity|UDP-galactose:N-acylsphingosine D-galactosyltransferase activity|UDPgalactose:N-acylsphingosine D-galactosyltransferase activity|uridine diphosphogalactose-acylsphingosine galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047263 GO:0047262 biolink:MolecularActivity polygalacturonate 4-alpha-galacturonosyltransferase activity Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP. EC:2.4.1.43|MetaCyc:2.4.1.43-RXN|RHEA:13573 go.json UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity|UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity|uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity http://purl.obolibrary.org/obo/GO_0047262 GO:1900008 biolink:BiologicalProcess obsolete negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging. go.json down regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing|down regulation of extrachromosomal rDNA circle accumulation during replicative cell aging|down regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging|down regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging|negative regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing|negative regulation of extrachromosomal rDNA circle accumulation during replicative cell aging|negative regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging True http://purl.obolibrary.org/obo/GO_1900008 GO:0047261 biolink:MolecularActivity steroid N-acetylglucosaminyltransferase activity Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H+ + UDP. EC:2.4.1.39|KEGG_REACTION:R04451|MetaCyc:2.4.1.39-RXN|RHEA:14153 go.json UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity|hydroxy steroid acetylglucosaminyltransferase activity|steroid acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047261 GO:0047260 biolink:MolecularActivity alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP. EC:2.4.1.36|MetaCyc:2.4.1.36-RXN|RHEA:14605 go.json GDP-glucose-glucosephosphate glucosyltransferase activity|GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|GDPglucose-glucose-phosphate glucosyltransferase activity|GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity|trehalose phosphate synthase (GDP-forming) activity http://purl.obolibrary.org/obo/GO_0047260 GO:1900007 biolink:BiologicalProcess obsolete regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging OBSOLETE. Any process that modulates the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging. go.json regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing|regulation of extrachromosomal rDNA circle accumulation during replicative cell aging|regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging True http://purl.obolibrary.org/obo/GO_1900007 GO:0106202 biolink:MolecularActivity obsolete translocase activity acting on amino acids and peptides linked to a decarboxylation reaction OBSOLETE. Catalysis of the translocation of amno acids and peptides linked to a decarboxylation reaction. EC:7.4.4.- go.json True http://purl.obolibrary.org/obo/GO_0106202 GO:0106201 biolink:MolecularActivity obsolete translocase activity acting on amino acids and peptides linked to the hydrolysis of a diphosphate OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a diphosphate. EC:7.4.3.- go.json True http://purl.obolibrary.org/obo/GO_0106201 GO:0106200 biolink:MolecularActivity obsolete translocase activity acting on amio acids and peptides linked to the hydrolysis of a nucleoside triphosphate OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a nucleoside triphosphate. EC:7.4.2.- go.json True http://purl.obolibrary.org/obo/GO_0106200 GO:1900009 biolink:BiologicalProcess obsolete positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging OBSOLETE. Any process that activates or increases the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging. go.json positive regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing|positive regulation of extrachromosomal rDNA circle accumulation during replicative cell aging|positive regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging|up regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing|up regulation of extrachromosomal rDNA circle accumulation during replicative cell aging|up regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging|up regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging True http://purl.obolibrary.org/obo/GO_1900009 GO:1900004 biolink:BiologicalProcess negative regulation of serine-type endopeptidase activity Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. go.json down regulation of blood coagulation factor activity|down regulation of serine-type endopeptidase activity|negative regulation of blood coagulation factor activity http://purl.obolibrary.org/obo/GO_1900004 gocheck_do_not_annotate GO:1900003 biolink:BiologicalProcess regulation of serine-type endopeptidase activity Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. go.json regulation of blood coagulation factor activity http://purl.obolibrary.org/obo/GO_1900003 gocheck_do_not_annotate GO:1900006 biolink:BiologicalProcess positive regulation of dendrite development Any process that activates or increases the frequency, rate or extent of dendrite development. go.json up regulation of dendrite development http://purl.obolibrary.org/obo/GO_1900006 GO:1900005 biolink:BiologicalProcess positive regulation of serine-type endopeptidase activity Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity. go.json positive regulation of blood coagulation factor activity|up regulation of blood coagulation factor activity|up regulation of serine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_1900005 gocheck_do_not_annotate GO:0047269 biolink:MolecularActivity poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP. EC:2.4.1.70|MetaCyc:2.4.1.53-RXN|RHEA:21012 go.json UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047269 GO:1900000 biolink:BiologicalProcess regulation of anthocyanin catabolic process Any process that modulates the frequency, rate or extent of anthocyanin catabolic process. go.json regulation of anthocyanin breakdown|regulation of anthocyanin catabolism|regulation of anthocyanin degradation http://purl.obolibrary.org/obo/GO_1900000 GO:0047268 biolink:MolecularActivity galactinol-raffinose galactosyltransferase activity Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol. EC:2.4.1.67|MetaCyc:2.4.1.67-RXN|RHEA:20776 go.json alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity|stachyose synthetase activity http://purl.obolibrary.org/obo/GO_0047268 GO:1900002 biolink:BiologicalProcess positive regulation of anthocyanin catabolic process Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process. go.json positive regulation of anthocyanin breakdown|positive regulation of anthocyanin catabolism|positive regulation of anthocyanin degradation|up regulation of anthocyanin breakdown|up regulation of anthocyanin catabolic process|up regulation of anthocyanin catabolism|up regulation of anthocyanin degradation http://purl.obolibrary.org/obo/GO_1900002 GO:0047267 biolink:MolecularActivity undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol. EC:2.4.1.54 go.json GDP mannose-undecaprenyl phosphate mannosyltransferase activity|GDP-D-mannose:lipid phosphate transmannosylase activity|GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity|guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity http://purl.obolibrary.org/obo/GO_0047267 GO:1900001 biolink:BiologicalProcess negative regulation of anthocyanin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process. go.json down regulation of anthocyanin breakdown|down regulation of anthocyanin catabolic process|down regulation of anthocyanin catabolism|down regulation of anthocyanin degradation|negative regulation of anthocyanin breakdown|negative regulation of anthocyanin catabolism|negative regulation of anthocyanin degradation http://purl.obolibrary.org/obo/GO_1900001 GO:0047266 biolink:MolecularActivity poly(ribitol-phosphate) beta-glucosyltransferase activity Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP. EC:2.4.1.53|MetaCyc:RXN-18017|RHEA:10068 go.json UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity|UDP-D-glucose polyribitol phosphate glucosyl transferase activity|UDP-D-glucose:polyribitol phosphate glucosyl transferase activity|UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity|UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity|uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047266 GO:0072209 biolink:BiologicalProcess metanephric mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072209 GO:0072208 biolink:BiologicalProcess metanephric smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072208 GO:0072207 biolink:BiologicalProcess metanephric epithelium development The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. go.json http://purl.obolibrary.org/obo/GO_0072207 GO:0072206 biolink:BiologicalProcess metanephric juxtaglomerular apparatus development The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate. go.json http://purl.obolibrary.org/obo/GO_0072206 GO:0072205 biolink:BiologicalProcess metanephric collecting duct development The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. go.json http://purl.obolibrary.org/obo/GO_0072205 GO:0072204 biolink:BiologicalProcess cell-cell signaling involved in metanephros development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ. go.json cell-cell signalling involved in metanephros development http://purl.obolibrary.org/obo/GO_0072204 GO:0072203 biolink:BiologicalProcess cell proliferation involved in metanephros development The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072203 GO:0072202 biolink:BiologicalProcess cell differentiation involved in metanephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072202 GO:0072201 biolink:BiologicalProcess negative regulation of mesenchymal cell proliferation Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json http://purl.obolibrary.org/obo/GO_0072201 GO:0072200 biolink:BiologicalProcess negative regulation of mesenchymal cell proliferation involved in ureter development Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. go.json negative regulation of ureter mesenchymal cell proliferation|negative regulation of ureteral mesenchymal cell proliferation http://purl.obolibrary.org/obo/GO_0072200 GO:0072232 biolink:BiologicalProcess metanephric proximal convoluted tubule segment 2 development The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride. go.json metanephric S2 development http://purl.obolibrary.org/obo/GO_0072232 GO:0047276 biolink:MolecularActivity N-acetyllactosaminide 3-alpha-galactosyltransferase activity Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP. EC:2.4.1.87|MetaCyc:2.4.1.151-RXN|RHEA:13013 go.json N-acetyllactosaminide alpha-1,3-galactosyltransferase activity|UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity|UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity|UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity|UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity|UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity|UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity|UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity|UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity|UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity|UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity|alpha-galactosyltransferase activity|beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity|beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity|glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity|uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity|uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity|uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity|uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity|uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047276 GO:0106210 biolink:BiologicalProcess culmorin biosynthetic process The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris. go.json culmorin anabolism|culmorin biosynthesis|culmorin formation|culmorin synthesis http://purl.obolibrary.org/obo/GO_0106210 GO:0047275 biolink:MolecularActivity glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. EC:2.4.1.86|MetaCyc:2.4.1.86-RXN|RHEA:16045 go.json GalT-4|UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity|UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity|paragloboside synthase activity|uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047275 GO:0072231 biolink:BiologicalProcess metanephric proximal convoluted tubule segment 1 development The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes. go.json metanephric S1 development http://purl.obolibrary.org/obo/GO_0072231 GO:0072230 biolink:BiologicalProcess metanephric proximal straight tubule development The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule. go.json metanephric S3 development http://purl.obolibrary.org/obo/GO_0072230 GO:0047274 biolink:MolecularActivity galactinol-sucrose galactosyltransferase activity Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol. EC:2.4.1.82|MetaCyc:2.4.1.82-RXN|RHEA:20161 go.json 1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity|alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity|galactinol:sucrose 6-galactosyl transferase activity|galactosyltransferase, galactinol-sucrose|raffinose synthase activity http://purl.obolibrary.org/obo/GO_0047274 GO:0047273 biolink:MolecularActivity galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. EC:2.4.1.79|MetaCyc:2.4.1.79-RXN|RHEA:22252|Reactome:R-HSA-8878914 go.json UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity|UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity|beta-3GalNAc-T1 activity|beta3GalNAc-T1|galactosylgalactosylglucosylceramide beta-D- activity|globoside synthase activity|globoside synthetase activity|globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity|globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047273 GO:1900019 biolink:BiologicalProcess regulation of protein kinase C activity Any process that modulates the frequency, rate or extent of protein kinase C activity. go.json regulation of PKC|regulation of PKC activity http://purl.obolibrary.org/obo/GO_1900019 gocheck_do_not_annotate GO:0047272 biolink:MolecularActivity phosphopolyprenol glucosyltransferase activity Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP. EC:2.4.1.78|MetaCyc:2.4.1.78-RXN go.json UDP-glucose:phosphopolyprenol D-glucosyltransferase activity|UDPglucose:phosphopolyprenol D-glucosyltransferase activity|UDPglucose:polyprenol monophosphate glucosyltransferase activity|uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047272 GO:0106214 biolink:BiologicalProcess regulation of vesicle fusion with Golgi apparatus Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. go.json http://purl.obolibrary.org/obo/GO_0106214 GO:0106213 biolink:BiologicalProcess kinetochore disassembly involved in meiotic chromosome organization The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. go.json kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle http://purl.obolibrary.org/obo/GO_0106213 GO:1900018 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. go.json True http://purl.obolibrary.org/obo/GO_1900018 GO:0047271 biolink:MolecularActivity glycosaminoglycan galactosyltransferase activity Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP. EC:2.4.1.74|MetaCyc:2.4.1.74-RXN go.json UDP-galactose:glycosaminoglycan D-galactosyltransferase activity|UDPgalactose:glycosaminoglycan D-galactosyltransferase activity|uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047271 GO:0047270 biolink:MolecularActivity lipopolysaccharide glucosyltransferase II activity Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP. EC:2.4.1.73|MetaCyc:RXN0-5125 go.json LPS glucosyltransferase II activity|UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity|UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity|uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047270 GO:0106212 biolink:BiologicalProcess centromere detachment from spindle pole body involved in meiotic chromosome organization The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. go.json centromere detachment from SPB involved in meiotic chromosome organization|centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle http://purl.obolibrary.org/obo/GO_0106212 GO:0106211 biolink:MolecularActivity inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H+ + phosphate. RHEA:59500 go.json 5-PP-InsP4 activity|5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity|5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity http://purl.obolibrary.org/obo/GO_0106211 GO:1900015 biolink:BiologicalProcess regulation of cytokine production involved in inflammatory response Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. go.json regulation of cytokine production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_1900015 GO:0106218 biolink:BiologicalProcess galactosaminogalactan biosynthetic process The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN). go.json GAG biosynthetic process|galactosaminogalactan anabolism|galactosaminogalactan biosynthesis|galactosaminogalactan formation|galactosaminogalactan synthesis http://purl.obolibrary.org/obo/GO_0106218 GO:1900014 biolink:BiologicalProcess obsolete cellular response to calcium ion involved in chemotaxis to cAMP OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. go.json cellular response to Ca2+ ion of chemotaxis to 3',5' cAMP|cellular response to Ca2+ ion of chemotaxis to 3',5'-cAMP|cellular response to Ca2+ ion of chemotaxis to adenosine 3',5'-cyclophosphate|cellular response to Ca2+ ion of chemotaxis to cAMP|cellular response to Ca2+ ion of chemotaxis to cyclic AMP|cellular response to calcium ion involved in chemotaxis to cAMP|cellular response to calcium ion of chemotaxis to 3',5' cAMP|cellular response to calcium ion of chemotaxis to 3',5'-cAMP|cellular response to calcium ion of chemotaxis to adenosine 3',5'-cyclophosphate|cellular response to calcium ion of chemotaxis to cAMP|cellular response to calcium ion of chemotaxis to cyclic AMP True http://purl.obolibrary.org/obo/GO_1900014 GO:0106217 biolink:BiologicalProcess tRNA C3-cytosine methylation The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine. go.json http://purl.obolibrary.org/obo/GO_0106217 GO:1900017 biolink:BiologicalProcess positive regulation of cytokine production involved in inflammatory response Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. go.json positive regulation of cytokine production involved in acute inflammatory response|up regulation of cytokine production involved in acute inflammatory response|up regulation of cytokine production involved in inflammatory response http://purl.obolibrary.org/obo/GO_1900017 GO:0106216 biolink:BiologicalProcess positive regulation of vesicle fusion with Golgi apparatus Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. go.json http://purl.obolibrary.org/obo/GO_0106216 GO:1900016 biolink:BiologicalProcess negative regulation of cytokine production involved in inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. go.json down regulation of cytokine production involved in acute inflammatory response|down regulation of cytokine production involved in inflammatory response|negative regulation of cytokine production involved in acute inflammatory response http://purl.obolibrary.org/obo/GO_1900016 GO:0106215 biolink:BiologicalProcess negative regulation of vesicle fusion with Golgi apparatus Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. go.json http://purl.obolibrary.org/obo/GO_0106215 GO:1900011 biolink:BiologicalProcess negative regulation of corticotropin-releasing hormone receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity. go.json down regulation of CRF receptor activity|down regulation of CRH receptor activity|down regulation of adrenocorticotropin-releasing hormone receptor activity|down regulation of corticotropin-releasing factor receptor activity|down regulation of corticotropin-releasing hormone receptor activity|negative regulation of CRF receptor activity|negative regulation of CRH receptor activity|negative regulation of adrenocorticotropin-releasing hormone receptor activity|negative regulation of corticotropin-releasing factor receptor activity http://purl.obolibrary.org/obo/GO_1900011 gocheck_do_not_annotate GO:1900010 biolink:BiologicalProcess regulation of corticotropin-releasing hormone receptor activity Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity. go.json regulation of CRF receptor activity|regulation of CRH receptor activity|regulation of adrenocorticotropin-releasing hormone receptor activity|regulation of corticotropin-releasing factor receptor activity http://purl.obolibrary.org/obo/GO_1900010 gocheck_do_not_annotate GO:0047279 biolink:MolecularActivity sn-glycerol-3-phosphate 1-galactosyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H+ + UDP. EC:2.4.1.96|KEGG_REACTION:R00854|MetaCyc:2.4.1.96-RXN|RHEA:20341 go.json UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity|UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity|UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity|UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity|glycerol 3-phosphate 1alpha-galactosyltransferase activity|isofloridoside-phosphate synthase activity|uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047279 GO:0047278 biolink:MolecularActivity bilirubin-glucuronoside glucuronosyltransferase activity Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside. KEGG_REACTION:R00062|RHEA:16885 go.json bilirubin glucuronoside glucuronosyltransferase activity|bilirubin monoglucuronide transglucuronidase activity|bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0047278 GO:1900013 biolink:BiologicalProcess obsolete cellular response to potassium ion involved in chemotaxis to cAMP OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. go.json cellular response to K+ ion of chemotaxis to 3',5' cAMP|cellular response to K+ ion of chemotaxis to 3',5'-cAMP|cellular response to K+ ion of chemotaxis to adenosine 3',5'-cyclophosphate|cellular response to K+ ion of chemotaxis to cAMP|cellular response to K+ ion of chemotaxis to cyclic AMP|cellular response to potassium ion involved in chemotaxis to cAMP|cellular response to potassium ion of chemotaxis to 3',5' cAMP|cellular response to potassium ion of chemotaxis to 3',5'-cAMP|cellular response to potassium ion of chemotaxis to adenosine 3',5'-cyclophosphate|cellular response to potassium ion of chemotaxis to cAMP|cellular response to potassium ion of chemotaxis to cyclic AMP|cellular response to potassium of chemotaxis to 3',5' cAMP|cellular response to potassium of chemotaxis to 3',5'-cAMP|cellular response to potassium of chemotaxis to adenosine 3',5'-cyclophosphate|cellular response to potassium of chemotaxis to cAMP|cellular response to potassium of chemotaxis to cyclic AMP True http://purl.obolibrary.org/obo/GO_1900013 GO:0047277 biolink:MolecularActivity globoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. EC:2.4.1.88|MetaCyc:2.4.1.88-RXN|RHEA:22164 go.json Forssman synthase activity|UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity|globoside acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047277 GO:1900012 biolink:BiologicalProcess positive regulation of corticotropin-releasing hormone receptor activity Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity. go.json positive regulation of CRF receptor activity|positive regulation of CRH receptor activity|positive regulation of adrenocorticotropin-releasing hormone receptor activity|positive regulation of corticotropin-releasing factor receptor activity|up regulation of CRF receptor activity|up regulation of CRH receptor activity|up regulation of adrenocorticotropin-releasing hormone receptor activity|up regulation of corticotropin-releasing factor receptor activity|up regulation of corticotropin-releasing hormone receptor activity http://purl.obolibrary.org/obo/GO_1900012 gocheck_do_not_annotate GO:0106219 biolink:MolecularActivity zinc ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc. go.json http://purl.obolibrary.org/obo/GO_0106219 GO:1900020 biolink:BiologicalProcess positive regulation of protein kinase C activity Any process that activates or increases the frequency, rate or extent of protein kinase C activity. go.json positive regulation of PKC|positive regulation of PKC activity|up regulation of PKC|up regulation of PKC activity http://purl.obolibrary.org/obo/GO_1900020 gocheck_do_not_annotate GO:0072239 biolink:BiologicalProcess metanephric glomerulus vasculature development The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. go.json glomerulus capillary development http://purl.obolibrary.org/obo/GO_0072239 GO:0072238 biolink:BiologicalProcess metanephric long nephron development The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros. go.json metanephric juxtamedullary nephron development http://purl.obolibrary.org/obo/GO_0072238 GO:0072237 biolink:BiologicalProcess metanephric proximal tubule development The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. go.json http://purl.obolibrary.org/obo/GO_0072237 GO:0072236 biolink:BiologicalProcess metanephric loop of Henle development The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros. go.json metanephric intermediate tubule development http://purl.obolibrary.org/obo/GO_0072236 GO:0072235 biolink:BiologicalProcess metanephric distal tubule development The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule. go.json http://purl.obolibrary.org/obo/GO_0072235 GO:0072234 biolink:BiologicalProcess metanephric nephron tubule development The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072234 GO:0072233 biolink:BiologicalProcess metanephric thick ascending limb development The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule. go.json metanephric TAL development http://purl.obolibrary.org/obo/GO_0072233 GO:0072221 biolink:BiologicalProcess metanephric distal convoluted tubule development The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. go.json http://purl.obolibrary.org/obo/GO_0072221 GO:0047287 biolink:MolecularActivity obsolete lactosylceramide alpha-2,6-N-sialyltransferase activity OBSOLETE. Catalysis of the reaction: beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+). go.json True http://purl.obolibrary.org/obo/GO_0047287 GO:0072220 biolink:BiologicalProcess metanephric descending thin limb development The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle. go.json http://purl.obolibrary.org/obo/GO_0072220 GO:0047286 biolink:MolecularActivity NAD+-diphthamide ADP-ribosyltransferase activity Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide. EC:2.4.2.36|MetaCyc:RXN-11372|RHEA:11820|Reactome:R-HSA-5336421 go.json ADP-ribosyltransferase activity|NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity|NAD-diphthamide ADP-ribosyltransferase activity|mono(ADP-ribosyl)transferase activity http://purl.obolibrary.org/obo/GO_0047286 GO:0106220 biolink:BiologicalProcess pyocyanine biosynthetic process The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. go.json pyocyanin biosynthetic process http://purl.obolibrary.org/obo/GO_0106220 GO:0047285 biolink:MolecularActivity flavonol-3-O-glycoside xylosyltransferase activity Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP. EC:2.4.2.35|MetaCyc:2.4.2.35-RXN|RHEA:19701 go.json UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0047285 GO:0047284 biolink:MolecularActivity dolichyl-xylosyl-phosphate-protein xylosyltransferase activity Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein. EC:2.4.2.33|MetaCyc:2.4.2.33-RXN|RHEA:18361 go.json dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0047284 GO:0106225 biolink:BiologicalProcess peptidyl-lysine 2-hydroxyisobutyrylation The 2-hydroxyisobutyrylation of a lysine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0106225 gocheck_do_not_annotate GO:0047283 biolink:MolecularActivity dolichyl-phosphate D-xylosyltransferase activity Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP. EC:2.4.2.32|MetaCyc:2.4.2.32-RXN|RHEA:15361 go.json UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity http://purl.obolibrary.org/obo/GO_0047283 GO:0047282 biolink:MolecularActivity dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H+. EC:2.4.2.27|KEGG_REACTION:R04222|MetaCyc:2.4.2.27-RXN|RHEA:24392 go.json dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity|dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity|thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity http://purl.obolibrary.org/obo/GO_0047282 GO:1900029 biolink:BiologicalProcess positive regulation of ruffle assembly Any process that activates or increases the frequency, rate or extent of ruffle assembly. go.json positive regulation of membrane ruffle formation|positive regulation of membrane ruffling|up regulation of membrane ruffle formation|up regulation of membrane ruffling|up regulation of ruffle assembly http://purl.obolibrary.org/obo/GO_1900029 GO:0106223 biolink:MolecularActivity germacrene A hydroxylase activity Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. EC:1.14.14.95|MetaCyc:RXN-19749|RHEA:30303 go.json germacrene A alcohol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0106223 GO:0047281 biolink:MolecularActivity dioxotetrahydropyrimidine phosphoribosyltransferase activity Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine. EC:2.4.2.20|MetaCyc:2.4.2.20-RXN|RHEA:10232 go.json 2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity|dioxotetrahydropyrimidine phosphoribosyl transferase activity|dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity|dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity|dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0047281 GO:0047280 biolink:MolecularActivity nicotinamide phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide. EC:2.4.2.12|KEGG_REACTION:R01271|MetaCyc:2.4.2.12-RXN|RHEA:16149|Reactome:R-HSA-197250 go.json NMN diphosphorylase activity|NMN pyrophosphorylase activity|NMN synthetase activity|nicotinamide mononucleotide pyrophosphorylase activity|nicotinamide mononucleotide synthetase activity|nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0047280 GO:0106222 biolink:MolecularActivity lncRNA binding Binding to a long noncoding RNA (lncRNA). go.json long noncoding RNA binding http://purl.obolibrary.org/obo/GO_0106222 GO:1900026 biolink:BiologicalProcess positive regulation of substrate adhesion-dependent cell spreading Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. go.json positive regulation of cell spreading during cell substrate adhesion|positive regulation of substrate adhesion dependent cell spreading|up regulation of cell spreading during cell substrate adhesion|up regulation of substrate adhesion dependent cell spreading|up regulation of substrate adhesion-dependent cell spreading http://purl.obolibrary.org/obo/GO_1900026 GO:0106229 biolink:MolecularActivity histone glutaryltransferase activity Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone. go.json http://purl.obolibrary.org/obo/GO_0106229 GO:1900025 biolink:BiologicalProcess negative regulation of substrate adhesion-dependent cell spreading Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. go.json down regulation of cell spreading during cell substrate adhesion|down regulation of substrate adhesion dependent cell spreading|down regulation of substrate adhesion-dependent cell spreading|negative regulation of cell spreading during cell substrate adhesion|negative regulation of substrate adhesion dependent cell spreading http://purl.obolibrary.org/obo/GO_1900025 GO:0106228 biolink:MolecularActivity peptide glutaryltransferase activity Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]. RHEA:18009 go.json http://purl.obolibrary.org/obo/GO_0106228 GO:0106227 biolink:BiologicalProcess peptidyl-lysine glutarylation The glutarylation of a lysine residue in a protein. go.json http://purl.obolibrary.org/obo/GO_0106227 gocheck_do_not_annotate GO:1900028 biolink:BiologicalProcess negative regulation of ruffle assembly Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly. go.json down regulation of membrane ruffle formation|down regulation of membrane ruffling|down regulation of ruffle assembly|negative regulation of membrane ruffle formation|negative regulation of membrane ruffling http://purl.obolibrary.org/obo/GO_1900028 GO:0106226 biolink:MolecularActivity peptide 2-hydroxyisobutyryltransferase activity Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide. RHEA:24180 go.json http://purl.obolibrary.org/obo/GO_0106226 GO:1900027 biolink:BiologicalProcess regulation of ruffle assembly Any process that modulates the frequency, rate or extent of ruffle assembly. go.json regulation of membrane ruffle formation|regulation of membrane ruffling http://purl.obolibrary.org/obo/GO_1900027 GO:1900022 biolink:BiologicalProcess regulation of D-erythro-sphingosine kinase activity Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity. go.json regulation of sphingosine kinase activity http://purl.obolibrary.org/obo/GO_1900022 gocheck_do_not_annotate GO:0047289 biolink:MolecularActivity galactosyldiacylglycerol alpha-2,3-sialyltransferase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H+. EC:2.4.3.5|KEGG_REACTION:R03468|MetaCyc:2.4.99.5-RXN|RHEA:11664 go.json http://purl.obolibrary.org/obo/GO_0047289 GO:1900024 biolink:BiologicalProcess regulation of substrate adhesion-dependent cell spreading Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. go.json regulation of cell spreading during cell substrate adhesion|regulation of substrate adhesion dependent cell spreading http://purl.obolibrary.org/obo/GO_1900024 GO:1900023 biolink:BiologicalProcess positive regulation of D-erythro-sphingosine kinase activity Any process that activates or increases the frequency, rate or extent of D-erythro-sphingosine kinase activity. go.json positive regulation of sphingosine kinase activity|up regulation of D-erythro-sphingosine kinase activity|up regulation of sphingosine kinase activity http://purl.obolibrary.org/obo/GO_1900023 gocheck_do_not_annotate GO:0047288 biolink:MolecularActivity beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+). EC:2.4.3.2|MetaCyc:2.4.99.2-RXN|RHEA:18021 go.json monosialoganglioside sialyltransferase http://purl.obolibrary.org/obo/GO_0047288 GO:1900031 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling. go.json global transcription regulation from Pol II promoter of calcium ion signaling|global transcription regulation from Pol II promoter of calcium signaling|global transcription regulation from Pol II promoter of calcium signalling|global transcription regulation from Pol II promoter of calcium-mediated signaling|global transcription regulation from Pol II promoter of calcium-mediated signalling|regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling|regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling|regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling|regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling|regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling|regulation of global transcription from Pol II promoter of calcium ion signaling|regulation of global transcription from Pol II promoter of calcium signaling|regulation of global transcription from Pol II promoter of calcium signalling|regulation of global transcription from Pol II promoter of calcium-mediated signaling|regulation of global transcription from Pol II promoter of calcium-mediated signalling|regulation of transcription from Pol II promoter of calcium ion signaling|regulation of transcription from Pol II promoter of calcium signaling|regulation of transcription from Pol II promoter of calcium signalling|regulation of transcription from Pol II promoter of calcium-mediated signaling|regulation of transcription from Pol II promoter of calcium-mediated signalling|regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling|regulation of transcription from RNA polymerase II promoter of calcium ion signaling|regulation of transcription from RNA polymerase II promoter of calcium signaling|regulation of transcription from RNA polymerase II promoter of calcium signalling|regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling|regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling|regulation of transcription from RNA polymerase II promoter, global of calcium ion signaling|regulation of transcription from RNA polymerase II promoter, global of calcium signaling|regulation of transcription from RNA polymerase II promoter, global of calcium signalling|regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signaling|regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signalling True http://purl.obolibrary.org/obo/GO_1900031 GO:1900030 biolink:BiologicalProcess regulation of pectin biosynthetic process Any process that modulates the frequency, rate or extent of pectin biosynthetic process. go.json regulation of pectin anabolism|regulation of pectin biosynthesis|regulation of pectin formation|regulation of pectin synthesis http://purl.obolibrary.org/obo/GO_1900030 GO:0047290 biolink:MolecularActivity alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP. EC:2.4.3.7|KEGG_REACTION:R04635|MetaCyc:2.4.99.7-RXN|RHEA:53896|Reactome:R-HSA-981809 go.json (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity|ST6GALNAC activity|alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity|cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity|sialyltransferase activity http://purl.obolibrary.org/obo/GO_0047290 GO:0072229 biolink:BiologicalProcess metanephric proximal convoluted tubule development The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule. go.json http://purl.obolibrary.org/obo/GO_0072229 GO:0072228 biolink:BiologicalProcess metanephric prebend segment development The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability. go.json http://purl.obolibrary.org/obo/GO_0072228 GO:0072227 biolink:BiologicalProcess metanephric macula densa development The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072227 GO:0072226 biolink:BiologicalProcess metanephric long descending thin limb bend development The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072226 GO:0072225 biolink:BiologicalProcess metanephric late distal convoluted tubule development The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive. go.json http://purl.obolibrary.org/obo/GO_0072225 GO:0072224 biolink:BiologicalProcess metanephric glomerulus development The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros. go.json metanephric glomerular development http://purl.obolibrary.org/obo/GO_0072224 GO:0072223 biolink:BiologicalProcess metanephric glomerular mesangium development The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072223 GO:0072222 biolink:BiologicalProcess metanephric early distal convoluted tubule development The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive. go.json http://purl.obolibrary.org/obo/GO_0072222 GO:0047298 biolink:MolecularActivity (S)-3-amino-2-methylpropionate transaminase activity Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. EC:2.6.1.22|KEGG_REACTION:R04188|MetaCyc:2.6.1.22-RXN|RHEA:13993 go.json (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity|(S)-3-amino-2-methylpropionate aminotransferase activity|L-3-aminoisobutyrate aminotransferase activity|L-3-aminoisobutyrate transaminase activity|L-3-aminoisobutyric aminotransferase activity|L-AIBAT activity|beta-aminobutyric transaminase activity|beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0047298 GO:0072254 biolink:BiologicalProcess metanephric glomerular mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072254 GO:0047297 biolink:MolecularActivity asparagine-oxo-acid transaminase activity Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate. EC:2.6.1.14|MetaCyc:2.6.1.14-RXN|RHEA:19813 go.json L-asparagine:2-oxo-acid aminotransferase activity|asparagine--oxo-acid aminotransferase activity|asparagine-keto acid aminotransferase activity|asparagine-oxo-acid aminotransferase activity http://purl.obolibrary.org/obo/GO_0047297 GO:0072253 biolink:BiologicalProcess metanephric juxtaglomerulus cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell. go.json http://purl.obolibrary.org/obo/GO_0072253 GO:0047296 biolink:MolecularActivity homospermidine synthase activity Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine. EC:2.5.1.44|MetaCyc:2.5.1.44-RXN|RHEA:18645 go.json putrescine:putrescine 4-aminobutyltransferase (ammonia-forming) http://purl.obolibrary.org/obo/GO_0047296 GO:0072252 biolink:BiologicalProcess metanephric juxtaglomerulus cell development The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072252 GO:0047295 biolink:MolecularActivity geranylgeranylglycerol-phosphate geranylgeranyltransferase activity Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. EC:2.5.1.42|KEGG_REACTION:R04520|MetaCyc:2.5.1.42-RXN|RHEA:18109 go.json geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity|geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity|geranylgeranyltransferase II http://purl.obolibrary.org/obo/GO_0047295 GO:0072251 biolink:BiologicalProcess metanephric juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072251 GO:0047294 biolink:MolecularActivity phosphoglycerol geranylgeranyltransferase activity Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. EC:2.5.1.41|KEGG_REACTION:R04158|MetaCyc:2.5.1.41-RXN|RHEA:23404 go.json geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity|geranylgeranyl-transferase activity|glycerol phosphate geranylgeranyltransferase activity http://purl.obolibrary.org/obo/GO_0047294 GO:0072250 biolink:BiologicalProcess metanephric podocyte cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. go.json metanephric glomerular visceral epithelial cell fate commitment http://purl.obolibrary.org/obo/GO_0072250 GO:0047293 biolink:MolecularActivity 4-hydroxybenzoate nonaprenyltransferase activity Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate. EC:2.5.1.39|MetaCyc:2.5.1.39-RXN|RHEA:17709 go.json 4-hydroxybenzoate transferase activity|nonaprenyl-4-hydroxybenzoate transferase activity|p-hydroxybenzoate dimethylallyltransferase activity|p-hydroxybenzoate polyprenyltransferase activity|p-hydroxybenzoic acid-polyprenyl transferase activity|p-hydroxybenzoic-polyprenyl transferase activity|solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity http://purl.obolibrary.org/obo/GO_0047293 GO:0047292 biolink:MolecularActivity trihydroxypterocarpan dimethylallyltransferase activity Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate. EC:2.5.1.36|MetaCyc:RXN-4509|MetaCyc:RXN-4510 go.json dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity|dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity|dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity|dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity http://purl.obolibrary.org/obo/GO_0047292 GO:0047291 biolink:MolecularActivity lactosylceramide alpha-2,3-sialyltransferase activity Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. EC:2.4.3.9|MetaCyc:2.4.99.9-RXN|RHEA:18417 go.json CMP-acetylneuraminate-lactosylceramide-sialyltransferase|GM3 synthase activity|cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity|cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase|ganglioside GM3 synthase activity http://purl.obolibrary.org/obo/GO_0047291 GO:1900037 biolink:BiologicalProcess regulation of cellular response to hypoxia Any process that modulates the frequency, rate or extent of cellular response to hypoxia. go.json regulation of cellular response to hypoxic stress|regulation of cellular response to lowered oxygen tension http://purl.obolibrary.org/obo/GO_1900037 GO:1900036 biolink:BiologicalProcess positive regulation of cellular response to heat Any process that activates or increases the frequency, rate or extent of cellular response to heat. go.json activation of cellular response to heat|activation of cellular response to heat stress|positive regulation of cellular response to heat stress|up regulation of cellular response to heat|up regulation of cellular response to heat stress|up-regulation of cellular response to heat|up-regulation of cellular response to heat stress|upregulation of cellular response to heat|upregulation of cellular response to heat stress http://purl.obolibrary.org/obo/GO_1900036 GO:1900039 biolink:BiologicalProcess positive regulation of cellular response to hypoxia Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia. go.json activation of cellular response to hypoxia|activation of cellular response to hypoxic stress|activation of cellular response to lowered oxygen tension|positive regulation of cellular response to hypoxic stress|positive regulation of cellular response to lowered oxygen tension|up regulation of cellular response to hypoxia|up regulation of cellular response to hypoxic stress|up regulation of cellular response to lowered oxygen tension|up-regulation of cellular response to hypoxia|up-regulation of cellular response to hypoxic stress|up-regulation of cellular response to lowered oxygen tension|upregulation of cellular response to hypoxia|upregulation of cellular response to hypoxic stress|upregulation of cellular response to lowered oxygen tension http://purl.obolibrary.org/obo/GO_1900039 GO:1900038 biolink:BiologicalProcess negative regulation of cellular response to hypoxia Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia. go.json down regulation of cellular response to hypoxia|down regulation of cellular response to hypoxic stress|down regulation of cellular response to lowered oxygen tension|down-regulation of cellular response to hypoxia|down-regulation of cellular response to hypoxic stress|down-regulation of cellular response to lowered oxygen tension|downregulation of cellular response to hypoxia|downregulation of cellular response to hypoxic stress|downregulation of cellular response to lowered oxygen tension|inhibition of cellular response to hypoxia|inhibition of cellular response to hypoxic stress|inhibition of cellular response to lowered oxygen tension|negative regulation of cellular response to hypoxic stress|negative regulation of cellular response to lowered oxygen tension http://purl.obolibrary.org/obo/GO_1900038 GO:1900033 biolink:BiologicalProcess negative regulation of trichome patterning Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning. go.json down regulation of trichome distribution|down regulation of trichome pattern biosynthesis|down regulation of trichome pattern formation|down regulation of trichome pattern specification|down regulation of trichome patterning|down regulation of trichome spacing|down-regulation of trichome distribution|down-regulation of trichome pattern biosynthesis|down-regulation of trichome pattern formation|down-regulation of trichome pattern specification|down-regulation of trichome patterning|down-regulation of trichome spacing|downregulation of trichome distribution|downregulation of trichome pattern biosynthesis|downregulation of trichome pattern formation|downregulation of trichome pattern specification|downregulation of trichome patterning|downregulation of trichome spacing|inhibition of trichome distribution|inhibition of trichome pattern biosynthesis|inhibition of trichome pattern formation|inhibition of trichome pattern specification|inhibition of trichome patterning|inhibition of trichome spacing|negative regulation of trichome distribution|negative regulation of trichome pattern biosynthesis|negative regulation of trichome pattern formation|negative regulation of trichome pattern specification|negative regulation of trichome spacing http://purl.obolibrary.org/obo/GO_1900033 GO:1900032 biolink:BiologicalProcess regulation of trichome patterning Any process that modulates the frequency, rate or extent of trichome patterning. go.json regulation of trichome distribution|regulation of trichome pattern biosynthesis|regulation of trichome pattern formation|regulation of trichome pattern specification|regulation of trichome spacing http://purl.obolibrary.org/obo/GO_1900032 GO:1900035 biolink:BiologicalProcess negative regulation of cellular response to heat Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat. go.json down regulation of cellular response to heat|down regulation of cellular response to heat stress|down-regulation of cellular response to heat|down-regulation of cellular response to heat stress|downregulation of cellular response to heat|downregulation of cellular response to heat stress|inhibition of cellular response to heat|inhibition of cellular response to heat stress|negative regulation of cellular response to heat stress http://purl.obolibrary.org/obo/GO_1900035 GO:1900034 biolink:BiologicalProcess regulation of cellular response to heat Any process that modulates the frequency, rate or extent of cellular response to heat. go.json regulation of cellular response to heat stress http://purl.obolibrary.org/obo/GO_1900034 GO:0047299 biolink:MolecularActivity tryptophan-phenylpyruvate transaminase activity Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine. EC:2.6.1.28|KEGG_REACTION:R01376|MetaCyc:2.6.1.28-RXN|RHEA:13741 go.json L-tryptophan-alpha-ketoisocaproate aminotransferase activity|L-tryptophan:phenylpyruvate aminotransferase activity|tryptophan--phenylpyruvate aminotransferase activity|tryptophan-phenylpyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047299 GO:1900040 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900040 GO:1900042 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900042 GO:1900041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900041 GO:0072259 biolink:BiologicalProcess metanephric interstitial fibroblast development The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure. go.json metanephros interstitial cell development http://purl.obolibrary.org/obo/GO_0072259 GO:0072258 biolink:BiologicalProcess metanephric interstitial fibroblast differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state. go.json metanephros interstitial cell differentiation http://purl.obolibrary.org/obo/GO_0072258 GO:0072257 biolink:BiologicalProcess metanephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state. go.json http://purl.obolibrary.org/obo/GO_0072257 GO:0072256 biolink:BiologicalProcess metanephric glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell. go.json http://purl.obolibrary.org/obo/GO_0072256 GO:0072255 biolink:BiologicalProcess metanephric glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0072255 GO:0072243 biolink:BiologicalProcess metanephric nephron epithelium development The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072243 GO:0072242 biolink:BiologicalProcess metanephric DCT cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell. go.json metanephric distal convoluted tubule cell fate commitment http://purl.obolibrary.org/obo/GO_0072242 GO:0072241 biolink:BiologicalProcess metanephric DCT cell development The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure. go.json metanephric distal convoluted tubule cell development http://purl.obolibrary.org/obo/GO_0072241 GO:0072240 biolink:BiologicalProcess metanephric DCT cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state. go.json metanephric distal convoluted tubule cell differentiation http://purl.obolibrary.org/obo/GO_0072240 GO:1900048 biolink:BiologicalProcess positive regulation of hemostasis Any process that activates or increases the frequency, rate or extent of hemostasis. go.json activation of hemostasis|up regulation of hemostasis|up-regulation of hemostasis|upregulation of hemostasis http://purl.obolibrary.org/obo/GO_1900048 GO:1900047 biolink:BiologicalProcess negative regulation of hemostasis Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis. go.json down regulation of hemostasis|down-regulation of hemostasis|downregulation of hemostasis|inhibition of hemostasis http://purl.obolibrary.org/obo/GO_1900047 GO:1900049 biolink:BiologicalProcess obsolete regulation of histone exchange OBSOLETE. Any process that modulates the frequency, rate or extent of histone exchange. go.json regulation of histone chaperone|regulation of histone displacement|regulation of histone replacement True http://purl.obolibrary.org/obo/GO_1900049 GO:1900044 biolink:BiologicalProcess regulation of protein K63-linked ubiquitination Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination. go.json regulation of protein K63-linked polyubiquitination http://purl.obolibrary.org/obo/GO_1900044 GO:1900043 biolink:BiologicalProcess obsolete leptin-mediated signaling pathway involved in negative regulation of appetite OBSOLETE. Any leptin-mediated signaling pathway that is involved in negative regulation of appetite. go.json adipocytokine signaling pathway of appetite suppression|adipocytokine signaling pathway of down regulation of appetite|adipocytokine signaling pathway of down-regulation of appetite|adipocytokine signaling pathway of downregulation of appetite|adipocytokine signaling pathway of inhibition of appetite|adipocytokine signaling pathway of negative regulation of appetite|adipocytokine signaling pathway of negative regulation of hunger|leptin-mediated signaling pathway involved in negative regulation of appetite|leptin-mediated signaling pathway of appetite suppression|leptin-mediated signaling pathway of down regulation of appetite|leptin-mediated signaling pathway of down-regulation of appetite|leptin-mediated signaling pathway of downregulation of appetite|leptin-mediated signaling pathway of inhibition of appetite|leptin-mediated signaling pathway of negative regulation of appetite|leptin-mediated signaling pathway of negative regulation of hunger|leptin-mediated signalling pathway of appetite suppression|leptin-mediated signalling pathway of down regulation of appetite|leptin-mediated signalling pathway of down-regulation of appetite|leptin-mediated signalling pathway of downregulation of appetite|leptin-mediated signalling pathway of inhibition of appetite|leptin-mediated signalling pathway of negative regulation of appetite|leptin-mediated signalling pathway of negative regulation of hunger True http://purl.obolibrary.org/obo/GO_1900043 GO:1900046 biolink:BiologicalProcess regulation of hemostasis Any process that modulates the frequency, rate or extent of hemostasis. go.json http://purl.obolibrary.org/obo/GO_1900046 GO:1900045 biolink:BiologicalProcess negative regulation of protein K63-linked ubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination. go.json down regulation of protein K63-linked polyubiquitination|down regulation of protein K63-linked ubiquitination|down-regulation of protein K63-linked polyubiquitination|down-regulation of protein K63-linked ubiquitination|downregulation of protein K63-linked polyubiquitination|downregulation of protein K63-linked ubiquitination|inhibition of protein K63-linked polyubiquitination|inhibition of protein K63-linked ubiquitination|negative regulation of protein K63-linked polyubiquitination http://purl.obolibrary.org/obo/GO_1900045 GO:1900051 biolink:BiologicalProcess obsolete positive regulation of histone exchange OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone exchange. go.json activation of histone chaperone|activation of histone exchange|activation of histone replacement|positive regulation of histone chaperone|positive regulation of histone replacement|up regulation of histone chaperone|up regulation of histone exchange|up regulation of histone replacement|up-regulation of histone chaperone|up-regulation of histone exchange|up-regulation of histone replacement|upregulation of histone chaperone|upregulation of histone exchange|upregulation of histone replacement True http://purl.obolibrary.org/obo/GO_1900051 GO:1900050 biolink:BiologicalProcess obsolete negative regulation of histone exchange OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange. go.json down regulation of histone chaperone|down regulation of histone exchange|down regulation of histone replacement|down-regulation of histone chaperone|down-regulation of histone exchange|down-regulation of histone replacement|downregulation of histone chaperone|downregulation of histone exchange|downregulation of histone replacement|inhibition of histone chaperone|inhibition of histone exchange|inhibition of histone replacement|negative regulation of histone chaperone|negative regulation of histone replacement True http://purl.obolibrary.org/obo/GO_1900050 GO:1900053 biolink:BiologicalProcess negative regulation of retinoic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process. go.json down regulation of retinoic acid anabolic process|down regulation of retinoic acid biosynthetic process|down-regulation of retinoic acid anabolic process|down-regulation of retinoic acid biosynthetic process|downregulation of retinoic acid anabolic process|downregulation of retinoic acid biosynthetic process|inhibition of retinoic acid anabolic process|inhibition of retinoic acid biosynthetic process|negative regulation of retinoic acid anabolic process http://purl.obolibrary.org/obo/GO_1900053 GO:1900052 biolink:BiologicalProcess regulation of retinoic acid biosynthetic process Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process. go.json regulation of retinoic acid anabolic process http://purl.obolibrary.org/obo/GO_1900052 GO:0072249 biolink:BiologicalProcess metanephric podocyte development The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. go.json metanephric glomerular visceral epithelial cell development http://purl.obolibrary.org/obo/GO_0072249 GO:0072248 biolink:BiologicalProcess metanephric podocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. go.json metanephric glomerular visceral epithelial cell differentiation http://purl.obolibrary.org/obo/GO_0072248 GO:0072247 biolink:BiologicalProcess metanephric glomerular parietal epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. go.json metanephric Bowman's capsule cell fate commitment http://purl.obolibrary.org/obo/GO_0072247 GO:0072246 biolink:BiologicalProcess metanephric glomerular parietal epithelial cell development The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. go.json metanephric Bowman's capsule development http://purl.obolibrary.org/obo/GO_0072246 GO:0072245 biolink:BiologicalProcess metanephric glomerular parietal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. go.json http://purl.obolibrary.org/obo/GO_0072245 GO:0072244 biolink:BiologicalProcess metanephric glomerular epithelium development The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072244 GO:0072276 biolink:BiologicalProcess metanephric glomerulus vasculature morphogenesis The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. go.json http://purl.obolibrary.org/obo/GO_0072276 GO:0072275 biolink:BiologicalProcess metanephric glomerulus morphogenesis The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. go.json http://purl.obolibrary.org/obo/GO_0072275 GO:0072274 biolink:BiologicalProcess metanephric glomerular basement membrane development The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration. go.json http://purl.obolibrary.org/obo/GO_0072274 GO:0072273 biolink:BiologicalProcess metanephric nephron morphogenesis The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072273 GO:0072272 biolink:BiologicalProcess proximal/distal pattern formation involved in metanephric nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). go.json proximal-distal pattern formation involved in metanephric nephron development|proximal/distal metanephric nephron patterning http://purl.obolibrary.org/obo/GO_0072272 GO:0072271 biolink:BiologicalProcess metanephric short descending thin limb development The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology. go.json http://purl.obolibrary.org/obo/GO_0072271 GO:0072270 biolink:BiologicalProcess metanephric short nephron development The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb. go.json http://purl.obolibrary.org/obo/GO_0072270 GO:1900059 biolink:BiologicalProcess positive regulation of sulfate assimilation Any process that activates or increases the frequency, rate or extent of sulfate assimilation. go.json activation of sulfate assimilation|activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|activation of sulphate assimilation|activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor|positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|positive regulation of sulphate assimilation|positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor|up regulation of sulfate assimilation|up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|up regulation of sulphate assimilation|up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor|up-regulation of sulfate assimilation|up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|up-regulation of sulphate assimilation|up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor|upregulation of sulfate assimilation|upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|upregulation of sulphate assimilation|upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_1900059 GO:1900058 biolink:BiologicalProcess regulation of sulfate assimilation Any process that modulates the frequency, rate or extent of sulfate assimilation. go.json regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor|regulation of sulphate assimilation|regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_1900058 GO:1900055 biolink:BiologicalProcess regulation of leaf senescence Any process that modulates the frequency, rate or extent of leaf senescence. go.json http://purl.obolibrary.org/obo/GO_1900055 GO:1900054 biolink:BiologicalProcess positive regulation of retinoic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process. go.json activation of retinoic acid anabolic process|activation of retinoic acid biosynthetic process|positive regulation of retinoic acid anabolic process|up regulation of retinoic acid anabolic process|up regulation of retinoic acid biosynthetic process|up-regulation of retinoic acid anabolic process|up-regulation of retinoic acid biosynthetic process|upregulation of retinoic acid anabolic process|upregulation of retinoic acid biosynthetic process http://purl.obolibrary.org/obo/GO_1900054 GO:1900057 biolink:BiologicalProcess positive regulation of leaf senescence Any process that activates or increases the frequency, rate or extent of leaf senescence. go.json activation of leaf senescence|up regulation of leaf senescence|up-regulation of leaf senescence|upregulation of leaf senescence http://purl.obolibrary.org/obo/GO_1900057 GO:1900056 biolink:BiologicalProcess negative regulation of leaf senescence Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence. go.json down regulation of leaf senescence|down-regulation of leaf senescence|downregulation of leaf senescence|inhibition of leaf senescence http://purl.obolibrary.org/obo/GO_1900056 GO:1900062 biolink:BiologicalProcess obsolete regulation of replicative cell aging OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging. go.json regulation of replicative cell ageing True http://purl.obolibrary.org/obo/GO_1900062 GO:1900061 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling. go.json activation of global transcription from RNA polymerase II promoter of calcium ion signaling|activation of global transcription from RNA polymerase II promoter of calcium signaling|activation of global transcription from RNA polymerase II promoter of calcium signalling|activation of global transcription from RNA polymerase II promoter of calcium-mediated signaling|activation of global transcription from RNA polymerase II promoter of calcium-mediated signalling|activation of transcription from RNA polymerase II promoter of calcium ion signaling|activation of transcription from RNA polymerase II promoter of calcium signaling|activation of transcription from RNA polymerase II promoter of calcium signalling|activation of transcription from RNA polymerase II promoter of calcium-mediated signaling|activation of transcription from RNA polymerase II promoter of calcium-mediated signalling|positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling|positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling|positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling|positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling|positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling|positive regulation of global transcription from Pol II promoter of calcium ion signaling|positive regulation of global transcription from Pol II promoter of calcium signaling|positive regulation of global transcription from Pol II promoter of calcium signalling|positive regulation of global transcription from Pol II promoter of calcium-mediated signaling|positive regulation of global transcription from Pol II promoter of calcium-mediated signalling|positive regulation of transcription from Pol II promoter of calcium ion signaling|positive regulation of transcription from Pol II promoter of calcium signaling|positive regulation of transcription from Pol II promoter of calcium signalling|positive regulation of transcription from Pol II promoter of calcium-mediated signaling|positive regulation of transcription from Pol II promoter of calcium-mediated signalling|positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling|positive regulation of transcription from RNA polymerase II promoter of calcium ion signaling|positive regulation of transcription from RNA polymerase II promoter of calcium signaling|positive regulation of transcription from RNA polymerase II promoter of calcium signalling|positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling|positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling|stimulation of global transcription from RNA polymerase II promoter of calcium ion signaling|stimulation of global transcription from RNA polymerase II promoter of calcium signaling|stimulation of global transcription from RNA polymerase II promoter of calcium signalling|stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling|stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling|stimulation of transcription from RNA polymerase II promoter of calcium ion signaling|stimulation of transcription from RNA polymerase II promoter of calcium signaling|stimulation of transcription from RNA polymerase II promoter of calcium signalling|stimulation of transcription from RNA polymerase II promoter of calcium-mediated signaling|stimulation of transcription from RNA polymerase II promoter of calcium-mediated signalling|up regulation of global transcription from RNA polymerase II promoter of calcium ion signaling|up regulation of global transcription from RNA polymerase II promoter of calcium signaling|up regulation of global transcription from RNA polymerase II promoter of calcium signalling|up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling|up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling|up regulation of transcription from RNA polymerase II promoter of calcium ion signaling|up regulation of transcription from RNA polymerase II promoter of calcium signaling|up regulation of transcription from RNA polymerase II promoter of calcium signalling|up regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling|up regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling|up-regulation of global transcription from RNA polymerase II promoter of calcium ion signaling|up-regulation of global transcription from RNA polymerase II promoter of calcium signaling|up-regulation of global transcription from RNA polymerase II promoter of calcium signalling|up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling|up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling|up-regulation of transcription from RNA polymerase II promoter of calcium ion signaling|up-regulation of transcription from RNA polymerase II promoter of calcium signaling|up-regulation of transcription from RNA polymerase II promoter of calcium signalling|up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling|up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling|upregulation of global transcription from RNA polymerase II promoter of calcium ion signaling|upregulation of global transcription from RNA polymerase II promoter of calcium signaling|upregulation of global transcription from RNA polymerase II promoter of calcium signalling|upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling|upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling|upregulation of transcription from RNA polymerase II promoter of calcium ion signaling|upregulation of transcription from RNA polymerase II promoter of calcium signaling|upregulation of transcription from RNA polymerase II promoter of calcium signalling|upregulation of transcription from RNA polymerase II promoter of calcium-mediated signaling|upregulation of transcription from RNA polymerase II promoter of calcium-mediated signalling True http://purl.obolibrary.org/obo/GO_1900061 GO:1900064 biolink:BiologicalProcess positive regulation of peroxisome organization Any process that activates or increases the frequency, rate or extent of peroxisome organization. go.json activation of peroxisome organisation|activation of peroxisome organization|activation of peroxisome organization and biogenesis|activation of peroxisome-assembly ATPase activity|positive regulation of peroxisome organisation|positive regulation of peroxisome organization and biogenesis|positive regulation of peroxisome-assembly ATPase activity|up regulation of peroxisome organisation|up regulation of peroxisome organization|up regulation of peroxisome organization and biogenesis|up regulation of peroxisome-assembly ATPase activity|up-regulation of peroxisome organisation|up-regulation of peroxisome organization|up-regulation of peroxisome organization and biogenesis|up-regulation of peroxisome-assembly ATPase activity|upregulation of peroxisome organisation|upregulation of peroxisome organization|upregulation of peroxisome organization and biogenesis|upregulation of peroxisome-assembly ATPase activity http://purl.obolibrary.org/obo/GO_1900064 GO:1900063 biolink:BiologicalProcess regulation of peroxisome organization Any process that modulates the frequency, rate or extent of peroxisome organization. go.json regulation of peroxisome organisation|regulation of peroxisome organization and biogenesis|regulation of peroxisome-assembly ATPase activity http://purl.obolibrary.org/obo/GO_1900063 GO:1900060 biolink:BiologicalProcess negative regulation of ceramide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process. go.json down regulation of ceramide anabolism|down regulation of ceramide biosynthesis|down regulation of ceramide biosynthetic process|down regulation of ceramide formation|down regulation of ceramide synthesis|down-regulation of ceramide anabolism|down-regulation of ceramide biosynthesis|down-regulation of ceramide biosynthetic process|down-regulation of ceramide formation|down-regulation of ceramide synthesis|downregulation of ceramide anabolism|downregulation of ceramide biosynthesis|downregulation of ceramide biosynthetic process|downregulation of ceramide formation|downregulation of ceramide synthesis|inhibition of ceramide anabolism|inhibition of ceramide biosynthesis|inhibition of ceramide biosynthetic process|inhibition of ceramide formation|inhibition of ceramide synthesis|negative regulation of ceramide anabolism|negative regulation of ceramide biosynthesis|negative regulation of ceramide formation|negative regulation of ceramide synthesis http://purl.obolibrary.org/obo/GO_1900060 GO:0072279 biolink:BiologicalProcess convergent extension involved in metanephric nephron morphogenesis The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072279 GO:0072278 biolink:BiologicalProcess metanephric comma-shaped body morphogenesis The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072278 GO:0072277 biolink:BiologicalProcess metanephric glomerular capillary formation The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0072277 GO:0072265 biolink:BiologicalProcess metanephric capsule morphogenesis The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. go.json http://purl.obolibrary.org/obo/GO_0072265 GO:0072264 biolink:BiologicalProcess metanephric glomerular endothelium development The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0072264 GO:0072263 biolink:BiologicalProcess metanephric intraglomerular mesangial cell proliferation The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. go.json http://purl.obolibrary.org/obo/GO_0072263 GO:0072262 biolink:BiologicalProcess metanephric glomerular mesangial cell proliferation involved in metanephros development The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population. go.json http://purl.obolibrary.org/obo/GO_0072262 GO:0072261 biolink:BiologicalProcess metanephric extraglomerular mesangial cell proliferation involved in metanephros development The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. go.json metanephric Goormaghtigh proliferation|metanephric lacis cell proliferation http://purl.obolibrary.org/obo/GO_0072261 GO:0072260 biolink:BiologicalProcess metanephric interstitial fibroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast. go.json metanephros interstitial cell fate commitment http://purl.obolibrary.org/obo/GO_0072260 GO:1900069 biolink:BiologicalProcess regulation of cellular hyperosmotic salinity response Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response. go.json regulation of cellular response to hyperosmotic salt stress http://purl.obolibrary.org/obo/GO_1900069 GO:1900066 biolink:BiologicalProcess positive regulation of ethanol catabolic process Any process that activates or increases the frequency, rate or extent of ethanol catabolic process. go.json activation of ethanol breakdown|activation of ethanol catabolic process|activation of ethanol catabolism|activation of ethanol degradation|positive regulation of ethanol breakdown|positive regulation of ethanol catabolism|positive regulation of ethanol degradation|up regulation of ethanol breakdown|up regulation of ethanol catabolic process|up regulation of ethanol catabolism|up regulation of ethanol degradation|up-regulation of ethanol breakdown|up-regulation of ethanol catabolic process|up-regulation of ethanol catabolism|up-regulation of ethanol degradation|upregulation of ethanol breakdown|upregulation of ethanol catabolic process|upregulation of ethanol catabolism|upregulation of ethanol degradation http://purl.obolibrary.org/obo/GO_1900066 GO:1900065 biolink:BiologicalProcess regulation of ethanol catabolic process Any process that modulates the frequency, rate or extent of ethanol catabolic process. go.json regulation of ethanol breakdown|regulation of ethanol catabolism|regulation of ethanol degradation http://purl.obolibrary.org/obo/GO_1900065 GO:1900068 biolink:BiologicalProcess negative regulation of cellular response to alkaline pH Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity. go.json down regulation of cellular response to alkaline pH|down regulation of cellular response to alkalinity|down regulation of cellular response to basic pH|down-regulation of cellular response to alkaline pH|down-regulation of cellular response to alkalinity|down-regulation of cellular response to basic pH|downregulation of cellular response to alkaline pH|downregulation of cellular response to alkalinity|downregulation of cellular response to basic pH|inhibition of cellular response to alkaline pH|inhibition of cellular response to alkalinity|inhibition of cellular response to basic pH|negative regulation of cellular response to alkalinity|negative regulation of cellular response to basic pH http://purl.obolibrary.org/obo/GO_1900068 GO:1900067 biolink:BiologicalProcess regulation of cellular response to alkaline pH Any process that modulates the frequency, rate or extent of cellular response to alkalinity. go.json regulation of cellular response to alkalinity|regulation of cellular response to basic pH http://purl.obolibrary.org/obo/GO_1900067 GO:1900073 biolink:BiologicalProcess regulation of neuromuscular synaptic transmission Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_1900073 GO:1900072 biolink:BiologicalProcess positive regulation of sulfite transport Any process that activates or increases the frequency, rate or extent of sulfite transport. go.json activation of sulfite transport|activation of sulphite transport|positive regulation of sulphite transport|up regulation of sulfite transport|up regulation of sulphite transport|up-regulation of sulfite transport|up-regulation of sulphite transport|upregulation of sulfite transport|upregulation of sulphite transport http://purl.obolibrary.org/obo/GO_1900072 GO:1900075 biolink:BiologicalProcess positive regulation of neuromuscular synaptic transmission Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission. go.json activation of neuromuscular synaptic transmission|up regulation of neuromuscular synaptic transmission|up-regulation of neuromuscular synaptic transmission|upregulation of neuromuscular synaptic transmission http://purl.obolibrary.org/obo/GO_1900075 GO:1900074 biolink:BiologicalProcess negative regulation of neuromuscular synaptic transmission Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission. go.json down regulation of neuromuscular synaptic transmission|down-regulation of neuromuscular synaptic transmission|downregulation of neuromuscular synaptic transmission|inhibition of neuromuscular synaptic transmission http://purl.obolibrary.org/obo/GO_1900074 GO:1900071 biolink:BiologicalProcess regulation of sulfite transport Any process that modulates the frequency, rate or extent of sulfite transport. go.json regulation of sulphite transport http://purl.obolibrary.org/obo/GO_1900071 GO:1900070 biolink:BiologicalProcess negative regulation of cellular hyperosmotic salinity response Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response. go.json down regulation of cellular hyperosmotic salinity response|down regulation of cellular response to hyperosmotic salt stress|down-regulation of cellular hyperosmotic salinity response|down-regulation of cellular response to hyperosmotic salt stress|downregulation of cellular hyperosmotic salinity response|downregulation of cellular response to hyperosmotic salt stress|inhibition of cellular hyperosmotic salinity response|inhibition of cellular response to hyperosmotic salt stress|negative regulation of cellular response to hyperosmotic salt stress http://purl.obolibrary.org/obo/GO_1900070 GO:0072269 biolink:BiologicalProcess metanephric long descending thin limb development The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla. go.json http://purl.obolibrary.org/obo/GO_0072269 GO:0072268 biolink:BiologicalProcess pattern specification involved in metanephros development Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate. go.json metanephros pattern formation|metanephros pattern specification|pattern formation involved in metanephros development http://purl.obolibrary.org/obo/GO_0072268 GO:0072267 biolink:BiologicalProcess metanephric capsule specification The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0072267 GO:0072266 biolink:BiologicalProcess metanephric capsule formation The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. go.json http://purl.obolibrary.org/obo/GO_0072266 GO:0106276 biolink:MolecularActivity biliberdin reductase NAD+ activity Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+. EC:1.3.1.24|RHEA:15797 go.json http://purl.obolibrary.org/obo/GO_0106276 GO:0106275 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106275 GO:0106274 biolink:MolecularActivity NAD+-protein-arginine ADP-ribosyltransferase activity Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. EC:2.4.2.31|MetaCyc:2.4.2.31-RXN|RHEA:19149|Reactome:R-HSA-1972385 go.json ADP-ribosyltransferase activity|NAD(+):L-arginine ADP-D-ribosyltransferase activity|NAD(P)(+)--arginine ADP-ribosyltransferase activity|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD(P)+:L-arginine ADP-D-ribosyltransferase activity|NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity|NADP+-protein-arginine ADP-ribosyltransferase activity|mono(ADP-ribosyl)transferase activity|peptidyl-arginine ADP-ribosylation activity|protein-arginine ADP-ribosyltransferase activity http://purl.obolibrary.org/obo/GO_0106274 GO:0106273 biolink:BiologicalProcess cytosol to ERGIC protein transport The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). go.json http://purl.obolibrary.org/obo/GO_0106273 GO:0106279 biolink:BiologicalProcess negative regulation of UDP-N-acetylglucosamine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process. go.json negative regulation of UDP-GlcNAc biosynthesis|negative regulation of UDP-GlcNAc biosynthetic process|negative regulation of UDP-N-acetylglucosamine anabolism|negative regulation of UDP-N-acetylglucosamine biosynthesis|negative regulation of UDP-N-acetylglucosamine formation|negative regulation of UDP-N-acetylglucosamine synthesis http://purl.obolibrary.org/obo/GO_0106279 GO:0106278 biolink:BiologicalProcess regulation of UDP-N-acetylglucosamine biosynthetic process Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process. go.json regulation of UDP-GlcNAc biosynthetic process|regulation of UDP-N-acetylglucosamine anabolism|regulation of UDP-N-acetylglucosamine biosynthesis|regulation of UDP-N-acetylglucosamine formation|regulation of UDP-N-acetylglucosamine synthesis http://purl.obolibrary.org/obo/GO_0106278 GO:0106277 biolink:MolecularActivity biliverdin reductase (NADP+) activity Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+. EC:1.3.1.24|RHEA:15793 go.json http://purl.obolibrary.org/obo/GO_0106277 GO:0106283 biolink:MolecularActivity ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH. RHEA:42028 go.json http://purl.obolibrary.org/obo/GO_0106283 GO:0106282 biolink:MolecularActivity isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD+ = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H+ + NADH. RHEA:42024 go.json http://purl.obolibrary.org/obo/GO_0106282 GO:0106281 biolink:MolecularActivity chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity Catalysis of the reaction: chenodeoxycholate + NAD+ = 7-oxolithocholate + H+ + NADH. RHEA:42036 go.json http://purl.obolibrary.org/obo/GO_0106281 GO:0106280 biolink:BiologicalProcess positive regulation of UDP-N-acetylglucosamine biosynthetic process Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process. go.json positive egulation of UDP-N-acetylglucosamine formation|positive regulation of UDP-GlcNAc biosynthetic process|positive regulation of UDP-N-acetylglucosamine anabolism|positive regulation of UDP-N-acetylglucosamine biosynthesis|positive regulation of UDP-N-acetylglucosamine synthesis http://purl.obolibrary.org/obo/GO_0106280 GO:0106287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106287 GO:0106286 biolink:MolecularActivity (E)-caffeate-CoA ligase activity Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate. RHEA:36299 go.json http://purl.obolibrary.org/obo/GO_0106286 GO:0106289 biolink:BiologicalProcess negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA Any process that stops, prevents, or reduces the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA. go.json http://purl.obolibrary.org/obo/GO_0106289 GO:0106288 biolink:BiologicalProcess regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA Any process that modulates the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA. go.json http://purl.obolibrary.org/obo/GO_0106288 GO:0106290 biolink:MolecularActivity trans-cinnamate-CoA ligase activity Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate. RHEA:64788 go.json http://purl.obolibrary.org/obo/GO_0106290 GO:0106294 biolink:MolecularActivity NADPH oxidase H202-forming activity Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2). RHEA:11260 go.json http://purl.obolibrary.org/obo/GO_0106294 GO:0106293 biolink:MolecularActivity NADH oxidase H202-forming activity Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2). RHEA:11264 go.json http://purl.obolibrary.org/obo/GO_0106293 GO:0106292 biolink:MolecularActivity superoxide-generating NADPH oxidase activity Catalysis of the reaction: NADPH + 2 O2 = H+ + NADP+ + 2 superoxide. RHEA:63180 go.json http://purl.obolibrary.org/obo/GO_0106292 GO:0106291 biolink:MolecularActivity superoxide-generating NADH oxidase activity Catalysis of the reaction: NADH + 2 O2 = H+ + NAD+ + 2 superoxide. RHEA:63184 go.json http://purl.obolibrary.org/obo/GO_0106291 GO:0106298 biolink:BiologicalProcess 13-series resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvin family 13-series, hydroxy fatty acids derived from docosapentaenoic acid. go.json http://purl.obolibrary.org/obo/GO_0106298 GO:0106297 biolink:BiologicalProcess E-series resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvin family E-series, hydroxy fatty acids derived from icosapentaenoic acid. go.json http://purl.obolibrary.org/obo/GO_0106297 GO:0106296 biolink:BiologicalProcess D-series resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvin family D-series, hydroxy fatty acids derived from docosahexaenoic acid. go.json http://purl.obolibrary.org/obo/GO_0106296 GO:0106295 biolink:BiologicalProcess resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvins, di- or trihydroxy fatty acids derived from omega-3 polyunsaturated fatty acids, specifically icosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid. go.json http://purl.obolibrary.org/obo/GO_0106295 GO:0106299 biolink:BiologicalProcess resolution phase response An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function. go.json http://purl.obolibrary.org/obo/GO_0106299 GO:0047207 biolink:MolecularActivity 1,2-beta-fructan 1F-fructosyltransferase activity Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1). EC:2.4.1.100|MetaCyc:2.4.1.100-RXN go.json 1,2-beta-D-fructan 1(F)-fructosyltransferase activity|1,2-beta-D-fructan 1F-fructosyltransferase activity|1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity|1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity|1,2-beta-fructan 1(F)-fructosyltransferase activity|2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity|2,1-fructan:2,1-fructan 1-fructosyltransferase activity|FFT activity|fructan:fructan fructosyl transferase activity http://purl.obolibrary.org/obo/GO_0047207 GO:0047206 biolink:MolecularActivity UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala). EC:2.3.2.10|MetaCyc:2.3.2.10-RXN|RHEA:12432 go.json UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity|UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity|alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity|uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity|uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity http://purl.obolibrary.org/obo/GO_0047206 GO:0047205 biolink:MolecularActivity quinate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA. EC:2.3.1.99|MetaCyc:2.3.1.99-RXN|RHEA:15021 go.json feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity|hydroxycinnamoyl coenzyme A-quinate transferase activity http://purl.obolibrary.org/obo/GO_0047205 GO:0047204 biolink:MolecularActivity chlorogenate-glucarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate. EC:2.3.1.98|KEGG_REACTION:R02998|MetaCyc:2.3.1.98-RXN|RHEA:23204 go.json chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity|chlorogenate:glucarate caffeoyltransferase activity|chlorogenic acid:glucaric acid O-caffeoyltransferase activity http://purl.obolibrary.org/obo/GO_0047204 GO:0047203 biolink:MolecularActivity 13-hydroxylupinine O-tigloyltransferase activity Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA. EC:2.3.1.93|KEGG_REACTION:R04205|MetaCyc:RXN-8694|RHEA:12360 go.json (E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity|13-hydroxylupanine acyltransferase activity|tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity http://purl.obolibrary.org/obo/GO_0047203 GO:0047202 biolink:MolecularActivity sinapoylglucose-choline O-sinapoyltransferase activity Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose. EC:2.3.1.91|KEGG_REACTION:R03075|MetaCyc:2.3.1.91-RXN|RHEA:12024 go.json 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity|sinapine synthase activity http://purl.obolibrary.org/obo/GO_0047202 GO:0047201 biolink:MolecularActivity beta-glucogallin O-galloyltransferase activity Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose. EC:2.3.1.90|KEGG_REACTION:R00049|MetaCyc:2.3.1.90-RXN|RHEA:11416 go.json 1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity http://purl.obolibrary.org/obo/GO_0047201 GO:0047200 biolink:MolecularActivity tetrahydrodipicolinate N-acetyltransferase activity Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA. EC:2.3.1.89|KEGG_REACTION:R04364|MetaCyc:2.3.1.89-RXN|RHEA:13085 go.json acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity|acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity|acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity|tetrahydrodipicolinate acetylase activity|tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity http://purl.obolibrary.org/obo/GO_0047200 GO:0047209 biolink:MolecularActivity coniferyl-alcohol glucosyltransferase activity Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP. EC:2.4.1.111|MetaCyc:2.4.1.111-RXN|RHEA:23944 go.json UDP-glucose coniferyl alcohol glucosyltransferase activity|UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity|UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity|uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047209 GO:0047208 biolink:MolecularActivity o-dihydroxycoumarin 7-O-glucosyltransferase activity Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP. EC:2.4.1.104|KEGG_REACTION:R03548|MetaCyc:2.4.1.104-RXN|RHEA:14325 go.json UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity|UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity|UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047208 GO:0106232 biolink:CellularComponent hydroxyisourate hydrolase complex A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin. go.json 5-hydroxyisourate hydrolase complex|HIU hydrolase complex|HIUH complex http://purl.obolibrary.org/obo/GO_0106232 GO:0047210 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047210 GO:0106231 biolink:MolecularActivity protein-propionyllysine depropionylase activity Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:23500 go.json http://purl.obolibrary.org/obo/GO_0106231 GO:0106230 biolink:BiologicalProcess protein depropionylation The removal of a propionyl group from a residue in a peptide or protein. go.json http://purl.obolibrary.org/obo/GO_0106230 gocheck_do_not_annotate GO:0106236 biolink:BiologicalProcess rhamnolipid biosynthesis The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal. go.json rhamnolipid production http://purl.obolibrary.org/obo/GO_0106236 GO:0106235 biolink:MolecularActivity ceramide-1-phosphate phosphatase activity Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate. RHEA:50888 go.json http://purl.obolibrary.org/obo/GO_0106235 GO:0106234 biolink:CellularComponent outer membrane protein complex Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC. go.json http://purl.obolibrary.org/obo/GO_0106234 GO:0106233 biolink:BiologicalProcess glycosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. go.json glycosome biogenesis|glycosome organisation|glycosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0106233 GO:0047218 biolink:MolecularActivity hydroxycinnamate 4-beta-glucosyltransferase activity Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP. EC:2.4.1.126|MetaCyc:2.4.1.126-RXN|RHEA:21636 go.json UDP-glucose-hydroxycinnamate glucosyltransferase activity|UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity|UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity|hydroxycinnamoyl glucosyltransferase activity|uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047218 GO:0106239 biolink:MolecularActivity 9,13-epoxylabda-14-ene synthase activity Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate. EC:4.2.3.189|RHEA:54512 go.json http://purl.obolibrary.org/obo/GO_0106239 GO:0047217 biolink:MolecularActivity sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose. EC:2.4.1.125|MetaCyc:2.4.1.125-RXN go.json GTF-S|sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase|sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity|sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity|water-soluble-glucan synthase activity http://purl.obolibrary.org/obo/GO_0047217 GO:0106238 biolink:MolecularActivity peregrinol diphosphate synthase activity Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O. EC:4.2.1.174|RHEA:54652 go.json http://purl.obolibrary.org/obo/GO_0106238 GO:0047216 biolink:MolecularActivity inositol 3-alpha-galactosyltransferase activity Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP. EC:2.4.1.123|MetaCyc:2.4.1.123-RXN|RHEA:12464 go.json UDP-D-galactose:inositol galactosyltransferase activity|UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity|UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity|UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity|galactinol synthase activity|inositol 1-alpha-galactosyltransferase activity|uridine diphosphogalactose-inositol galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047216 GO:0047215 biolink:MolecularActivity indole-3-acetate beta-glucosyltransferase activity Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP. EC:2.4.1.121|KEGG_REACTION:R03094|MetaCyc:2.4.1.121-RXN|RHEA:14921 go.json IAA-Glu synthetase activity|IAA-glucose synthase activity|IAGlu synthase activity|UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity|UDP-glucose:auxin glucosyltransferase activity|UDP-glucose:indol-3-acetic acid glucosyltransferase activity|UDP-glucose:indol-3-ylacetate glucosyl-transferase activity|UDP-glucose:indol-3-ylacetate glucosyltransferase activity|UDPG-indol-3-ylacetyl glucosyl transferase activity|UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity|indol-3-ylacetylglucose synthase activity|uridine diphosphoglucose-indoleacetate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047215 GO:0106237 biolink:MolecularActivity arachidonate 12(R)-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. RHEA:41336 go.json http://purl.obolibrary.org/obo/GO_0106237 GO:0047214 biolink:MolecularActivity cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP. EC:2.4.1.116|MetaCyc:2.4.1.116-RXN|RHEA:12144 go.json UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity|UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity|cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity|uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047214 GO:0047213 biolink:MolecularActivity anthocyanidin 3-O-glucosyltransferase activity Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. EC:2.4.1.115|MetaCyc:2.4.1.115-RXN|RHEA:20093 go.json 3-GT activity|UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity|UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity|UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity|UDP-glucose:cyanidin-3-O-glucosyltransferase activity|uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047213 GO:0047212 biolink:MolecularActivity 2-coumarate O-beta-glucosyltransferase activity Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H+ + UDP. EC:2.4.1.114|KEGG_REACTION:R03710|MetaCyc:2.4.1.114-RXN|RHEA:10236 go.json UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity|UDPG:o-coumaric acid O-glucosyltransferase activity|UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-o-coumarate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047212 GO:0047211 biolink:MolecularActivity alpha-1,4-glucan-protein synthase (ADP-forming) activity Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP. EC:2.4.1.113|MetaCyc:2.4.1.113-RXN go.json 1,4alpha-glucan-protein synthase (ADP-forming) activity|ADP-glucose:protein 4-alpha-D-glucosyltransferase activity|ADPglucose:protein 4-alpha-D-glucosyltransferase activity|ADPglucose:protein glucosyltransferase activity|adenosine diphosphoglucose-protein glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047211 GO:0047219 biolink:MolecularActivity monoterpenol beta-glucosyltransferase activity Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP. EC:2.4.1.127|KEGG_REACTION:R02179|MetaCyc:2.4.1.127-RXN|RHEA:11520 go.json UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity|UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity|UDPglucose:monoterpenol glucosyltransferase activity|uridine diphosphoglucose-monoterpenol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047219 GO:0106243 biolink:MolecularActivity syn-isopimara-7,15-diene synthase activity Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene. RHEA:62188 go.json http://purl.obolibrary.org/obo/GO_0106243 GO:0047221 biolink:MolecularActivity sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP. EC:2.4.1.137|KEGG_REACTION:R00853|MetaCyc:2.4.1.137-RXN|RHEA:14285 go.json FPS|UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity|UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity|UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity|UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity|floridoside phosphate synthase activity|floridoside phosphate synthetase activity|floridoside-phosphate synthase activity http://purl.obolibrary.org/obo/GO_0047221 GO:0047220 biolink:MolecularActivity galactosylxylosylprotein 3-beta-galactosyltransferase activity Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. EC:2.4.1.134|MetaCyc:2.4.1.134-RXN|RHEA:11780|Reactome:R-HSA-1889978|Reactome:R-HSA-4420365 go.json UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity|UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity|galactosyltransferase II activity|uridine diphosphogalactose-galactosylxylose galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047220 GO:0106242 biolink:MolecularActivity kolavenyl diphosphate synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate. EC:5.5.1.29|RHEA:54676 go.json http://purl.obolibrary.org/obo/GO_0106242 GO:0106240 biolink:MolecularActivity labd-13Z-ene-9,15,16-triol synthase activity Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]. RHEA:62192 go.json http://purl.obolibrary.org/obo/GO_0106240 GO:0106247 biolink:BiologicalProcess negative regulation of poly(A)-specific ribonuclease activity Any process that stops, prevents or reduces the frequency, rate or extent of poly(A)-specific ribonuclease activity. go.json http://purl.obolibrary.org/obo/GO_0106247 gocheck_do_not_annotate GO:0106246 biolink:BiologicalProcess regulation of poly(A)-specific ribonuclease activity Any process that modulates the rate, frequency or extent of the catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. go.json http://purl.obolibrary.org/obo/GO_0106246 gocheck_do_not_annotate GO:0106245 biolink:MolecularActivity L-serine-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine. EC:2.7.8.29|RHEA:27606 go.json http://purl.obolibrary.org/obo/GO_0106245 GO:0106244 biolink:MolecularActivity eupatolide synthase activity Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]. EC:1.14.14.169|RHEA:57972 go.json http://purl.obolibrary.org/obo/GO_0106244 GO:0047229 biolink:MolecularActivity 13-hydroxydocosanoate 13-beta-glucosyltransferase activity Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP. EC:2.4.1.158|MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN|RHEA:22316 go.json 13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity|UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity|UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity|UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity|UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity|uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047229 GO:0047228 biolink:MolecularActivity 1,2-diacylglycerol 3-glucosyltransferase activity Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP. EC:2.4.1.157|MetaCyc:2.4.1.157-RXN go.json UDP-glucose-diacylglycerol glucosyltransferase activity|UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity|UDP-glucose:1,2-diacylglycerol glucosyltransferase activity|UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity|UDPglucose:diacylglycerol glucosyltransferase activity|uridine diphosphoglucose-diacylglycerol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047228 GO:0106249 biolink:CellularComponent Nicalin-NOMO complex A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147. go.json Nicalin-TMEM147-NOMO complex http://purl.obolibrary.org/obo/GO_0106249 GO:0047227 biolink:MolecularActivity indolylacetyl-myo-inositol galactosyltransferase activity Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H+ + UDP. EC:2.4.1.156|KEGG_REACTION:R04334|MetaCyc:2.4.1.156-RXN|RHEA:21148 go.json UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity|UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity|indol-3-ylacetyl-myo-inositol galactoside synthase activity|uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047227 GO:0106248 biolink:BiologicalProcess positive regulation of poly(A)-specific ribonuclease activity Any process that activates or increases the frequency, rate or extent of poly(A)-specific ribonuclease activity. go.json http://purl.obolibrary.org/obo/GO_0106248 gocheck_do_not_annotate GO:0047226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047226 GO:0047225 biolink:MolecularActivity acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP. EC:2.4.1.148|MetaCyc:2.4.1.148-RXN go.json O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity|UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity|core 4 beta6-GalNAc-transferase activity|core 6-beta-GalNAc-transferase B activity|core 6beta-GalNAc-transferase B|uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B http://purl.obolibrary.org/obo/GO_0047225 GO:0047224 biolink:MolecularActivity acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP. EC:2.4.1.147|MetaCyc:2.4.1.147-RXN go.json O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity|core 3-beta-GlcNAc-transferase activity|core 3beta-GlcNAc-transferase activity|mucin core 3 beta3-GlcNAc-transferase activity|uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047224 GO:0047223 biolink:MolecularActivity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP. EC:2.4.1.146|MetaCyc:2.4.1.146-RXN|Reactome:R-HSA-5617037|Reactome:R-HSA-5617096 go.json O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity|elongation 3-beta-GalNAc-transferase activity|elongation 3beta-GalNAc-transferase activity|uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating) http://purl.obolibrary.org/obo/GO_0047223 GO:0047222 biolink:MolecularActivity mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP. EC:2.4.1.138|MetaCyc:2.4.1.138-RXN|RHEA:13705 go.json UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity|alpha-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047222 GO:0106250 biolink:MolecularActivity DNA-binding transcription repressor activity, RNA polymerase III-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III. go.json http://purl.obolibrary.org/obo/GO_0106250 GO:0106254 biolink:MolecularActivity lipid sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid. go.json lipid sensing activity http://purl.obolibrary.org/obo/GO_0106254 GO:0047232 biolink:MolecularActivity galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP. EC:2.4.1.164|MetaCyc:2.4.1.150-RXN go.json UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase http://purl.obolibrary.org/obo/GO_0047232 GO:0106253 biolink:BiologicalProcess positive regulation of DNA strand resection involved in replication fork processing Any process that activates or increases the frequency, rate or extent of DNA strand resection involved in replication fork processing. go.json http://purl.obolibrary.org/obo/GO_0106253 GO:0047231 biolink:MolecularActivity pyridoxine 5'-O-beta-D-glucosyltransferase activity Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H+ + UDP. EC:2.4.1.160|KEGG_REACTION:R01912|MetaCyc:2.4.1.160-RXN|RHEA:20177 go.json UDP-glucose-pyridoxine glucosyltransferase activity|UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity|UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity|UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047231 GO:0047230 biolink:MolecularActivity flavonol-3-O-glucoside L-rhamnosyltransferase activity Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP. EC:2.4.1.159|MetaCyc:2.4.1.159-RXN|RHEA:22528 go.json UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity|UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity|uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity http://purl.obolibrary.org/obo/GO_0047230 GO:0106251 biolink:MolecularActivity N4-acetylcytidine amidohydrolase activity Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate. RHEA:62932 go.json http://purl.obolibrary.org/obo/GO_0106251 GO:0106258 biolink:MolecularActivity L-serine-phosphatidylcholine phosphatidyltransferase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline. RHEA:45088 go.json http://purl.obolibrary.org/obo/GO_0106258 GO:0106257 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0106257 GO:0106256 biolink:MolecularActivity hydroperoxy icosatetraenoate dehydratase activity A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O. EC:4.2.1.152|RHEA:55556 go.json http://purl.obolibrary.org/obo/GO_0106256 GO:0106255 biolink:MolecularActivity hydroperoxy icosatetraenoate isomerase activity A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate. EC:5.4.4.7|RHEA:55560 go.json http://purl.obolibrary.org/obo/GO_0106255 GO:0047239 biolink:MolecularActivity hydroxymandelonitrile glucosyltransferase activity Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H+ + taxiphyllin + UDP. EC:2.4.1.178|KEGG_REACTION:R02709|MetaCyc:2.4.1.178-RXN|RHEA:15961 go.json UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity|UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity|cyanohydrin glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047239 GO:0047238 biolink:MolecularActivity glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. EC:2.4.1.175|MetaCyc:RXN-16325|Reactome:R-HSA-1971482|Reactome:R-HSA-1971487|Reactome:R-HSA-3595176|Reactome:R-HSA-9632033 go.json N-acetylgalactosaminyltransferase II activity|UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|chondroitin synthase activity|glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity http://purl.obolibrary.org/obo/GO_0047238 GO:0106259 biolink:BiologicalProcess cell-to-cell migration in host The directional movement of a symbiont from one host cell to another. go.json http://purl.obolibrary.org/obo/GO_0106259 GO:0047237 biolink:MolecularActivity glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. EC:2.4.1.174|MetaCyc:2.4.1.174-RXN|RHEA:23464 go.json N-acetylgalactosaminyltransferase I activity|UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I|uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity http://purl.obolibrary.org/obo/GO_0047237 GO:0047236 biolink:MolecularActivity methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP. EC:2.4.1.171|MetaCyc:2.4.1.171-RXN|RHEA:20205 go.json UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity|UDPglucose-methylazoxymethanol glucosyltransferase activity|cycasin synthase activity|methyl-ONN-azoxymethanol glucosyltransferase activity|uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047236 GO:0047235 biolink:MolecularActivity sucrose 6F-alpha-galactotransferase activity Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP. EC:2.4.1.167|MetaCyc:2.4.1.167-RXN|RHEA:10088 go.json UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity|UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity|UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity|sucrose 6(F)-alpha-galactosyltransferase activity|sucrose 6F-alpha-galactosyltransferase activity|uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047235 GO:0047234 biolink:MolecularActivity raffinose-raffinose alpha-galactotransferase activity Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose. EC:2.4.1.166|MetaCyc:RXN-11490|RHEA:14125 go.json raffinose (raffinose donor) galactosyltransferase activity|raffinose-raffinose a-galactosyltransferase activity|raffinose-raffinose alpha-galactosyltransferase activity|raffinose:raffinose alpha-D-galactosyltransferase activity|raffinose:raffinose alpha-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047234 GO:0047233 biolink:MolecularActivity N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. EC:2.4.1.165|MetaCyc:2.4.1.165-RXN|RHEA:13569 go.json UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047233 GO:0106261 biolink:MolecularActivity tRNA uridine(34) acetyltransferase activity Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine. EC:2.3.1.311|RHEA:61020 go.json http://purl.obolibrary.org/obo/GO_0106261 GO:0106260 biolink:MolecularActivity DNA-DNA tethering activity Bridging together two regions of a DNA molecule. go.json double-stranded DNA bridging|dsDNA bridging http://purl.obolibrary.org/obo/GO_0106260 GO:0047243 biolink:MolecularActivity flavanone 7-O-beta-glucosyltransferase activity Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP. EC:2.4.1.185|MetaCyc:2.4.1.185-RXN go.json UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity|UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity|hesperetin 7-O-glucosyl-transferase activity|naringenin 7-O-glucosyltransferase activity|uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047243 GO:0106265 biolink:MolecularActivity THPH synthase activity Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA. RHEA:64352 go.json polyketide syntase http://purl.obolibrary.org/obo/GO_0106265 GO:0047242 biolink:MolecularActivity hydroxyanthraquinone glucosyltransferase activity Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP. EC:2.4.1.181|MetaCyc:2.4.1.181-RXN go.json UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity|UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity|anthraquinone-specific glucosyltransferase activity|uridine diphosphoglucose-anthraquinone glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047242 GO:0106264 biolink:MolecularActivity protein serine kinase activity (using GTP as donor) Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein]. RHEA:64020 go.json http://purl.obolibrary.org/obo/GO_0106264 GO:0047241 biolink:MolecularActivity lipopolysaccharide N-acetylmannosaminouronosyltransferase activity Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP. EC:2.4.1.180|MetaCyc:UDPMANACATRANS-RXN|RHEA:28366 go.json LPS N-acetylmannosaminouronosyltransferase activity|ManNAcA transferase activity|UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity|uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0047241 GO:0106263 biolink:MolecularActivity 1-acylglycerophosphoserine O-acyltransferase activity Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA. RHEA:33191 go.json http://purl.obolibrary.org/obo/GO_0106263 GO:0047240 biolink:MolecularActivity lactosylceramide beta-1,3-galactosyltransferase activity Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H+ + UDP. EC:2.4.1.179|KEGG_REACTION:R04431|MetaCyc:2.4.1.179-RXN|RHEA:18413 go.json UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity|UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity|uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047240 GO:0106262 biolink:MolecularActivity 1-acylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA. RHEA:32995 go.json http://purl.obolibrary.org/obo/GO_0106262 GO:0106268 biolink:MolecularActivity 3,5-dichloro-THPH methyl transferase activity Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine. RHEA:48396 go.json DIF-1 syntase http://purl.obolibrary.org/obo/GO_0106268 GO:0106267 biolink:MolecularActivity 3,5 dichloro-THPH synthase activity Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O. RHEA:64360 go.json http://purl.obolibrary.org/obo/GO_0106267 GO:0106266 biolink:MolecularActivity 3-chloro THPH synthase activity Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O. RHEA:64356 go.json http://purl.obolibrary.org/obo/GO_0106266 GO:0047249 biolink:MolecularActivity sarsapogenin 3-beta-glucosyltransferase activity Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H+ + UDP. EC:2.4.1.193|KEGG_REACTION:R04359|MetaCyc:2.4.1.193-RXN|RHEA:14461 go.json UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity|UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity|sarsapogenin 3beta-glucosyltransferase activity|uridine diphosphoglucose-sarsapogenin glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047249 GO:0047248 biolink:MolecularActivity nuatigenin 3-beta-glucosyltransferase activity Catalysis of the reaction: nuatigenin + UDP-D-glucose = H+ + nuatigenin 3-beta-D-glucopyranoside + UDP. EC:2.4.1.192|KEGG_REACTION:R04577|MetaCyc:2.4.1.192-RXN|RHEA:19329 go.json UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity|UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity|nuatigenin 3beta-glucosyltransferase activity|uridine diphosphoglucose-nuatigenin glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047248 GO:0047247 biolink:MolecularActivity luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP. EC:2.4.1.191|KEGG_REACTION:R06828|MetaCyc:2.4.1.191-RXN|RHEA:22116 go.json LDT|UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity|UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity|UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity|UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity|uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0047247 GO:0047246 biolink:MolecularActivity luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP. EC:2.4.1.190|KEGG_REACTION:R06827|MetaCyc:2.4.1.190-RXN|RHEA:14149 go.json LMT activity|UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity|UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity|luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity|uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0047246 GO:0047245 biolink:MolecularActivity N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. EC:2.4.1.188|MetaCyc:2.4.1.188-RXN|RHEA:20952 go.json UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity|UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity|UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity|uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0047245 GO:0047244 biolink:MolecularActivity N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. EC:2.4.1.187|MetaCyc:TEICHOICSYN2-RXN|RHEA:16053 go.json N-acetylmannosaminyltransferase activity|UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity|UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity|uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0047244 GO:0106272 biolink:BiologicalProcess protein localization to ERGIC A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). go.json http://purl.obolibrary.org/obo/GO_0106272 GO:0106271 biolink:MolecularActivity D-arabinose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH. EC:1.1.1.117|RHEA:21892 go.json http://purl.obolibrary.org/obo/GO_0106271 GO:0180001 biolink:MolecularActivity cyclic-di-AMP binding Binding to a cyclic di-AMP nucleotide. go.json cyclic dimeric adenosine monophosphate binding http://purl.obolibrary.org/obo/GO_0180001 GO:0180000 biolink:MolecularActivity histone methyltransferase inhibitor activity Binds to and stops, prevents or reduces the activity of a histone methyltransferase. go.json http://purl.obolibrary.org/obo/GO_0180000 GO:0180003 biolink:MolecularActivity S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out). RHEA:75479 go.json http://purl.obolibrary.org/obo/GO_0180003 GO:0180002 biolink:BiologicalProcess renal zinc excretion The elimination of zinc ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. go.json renal zinc ion excretion|renal zinc secretion http://purl.obolibrary.org/obo/GO_0180002 GO:0180005 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate. go.json RNA polymerase II C-terminal domain T4 phosphatase activity http://purl.obolibrary.org/obo/GO_0180005 GO:0180004 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate. go.json RNA polymerase II C-terminal domain Y1 phosphatase activity http://purl.obolibrary.org/obo/GO_0180004 GO:0180007 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate. go.json RNA polymerase II C-terminal domain S5 phosphatase activity http://purl.obolibrary.org/obo/GO_0180007 GO:0180006 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate. go.json RNA polymerase II C-terminal domain S2 phosphatase activity http://purl.obolibrary.org/obo/GO_0180006 GO:0180009 biolink:MolecularActivity broad specificity neutral L-amino acid:basic L-amino acid antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out). go.json neutral L-amino acid:cationic L-amino acid antiporter activit|neutral L-amino acid:dibasic L-amino acid antiporter activity|neutral L-amino acid:positively-charged polar L-amino acid antiporter activity|system b(0,+)-type activity http://purl.obolibrary.org/obo/GO_0180009 GO:0180008 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate. go.json RNA polymerase II C-terminal domain S7 phosphatase activity http://purl.obolibrary.org/obo/GO_0180008 GO:0106078 biolink:MolecularActivity histone succinyltransferase activity Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone. go.json http://purl.obolibrary.org/obo/GO_0106078 GO:0106077 biolink:BiologicalProcess histone succinylation The modification of a histone by the addition of an succinyl group. go.json http://purl.obolibrary.org/obo/GO_0106077 gocheck_do_not_annotate GO:0106076 biolink:MolecularActivity peptide-lysine-N-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide. go.json http://purl.obolibrary.org/obo/GO_0106076 GO:0106075 biolink:MolecularActivity peptide N-succinyltransferase activity Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide. go.json http://purl.obolibrary.org/obo/GO_0106075 GO:0106081 biolink:BiologicalProcess maltose import across plasma membrane The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0106081 GO:0106080 biolink:MolecularActivity GATOR1 complex binding Binding to a GATOR1 complex. go.json http://purl.obolibrary.org/obo/GO_0106080 GO:0106084 biolink:CellularComponent mitotic nuclear membrane microtubule tethering complex A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane. go.json Mps2-Bbp1-Spc29 complex|nuclear membrane mitotic spindle pole body tethering complex http://purl.obolibrary.org/obo/GO_0106084 GO:0106083 biolink:CellularComponent nuclear membrane protein complex Any protein complex that is part of the nuclear membrane. go.json http://purl.obolibrary.org/obo/GO_0106083 GO:0106082 biolink:BiologicalProcess sucrose import across plasma membrane The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0106082 GO:0106089 biolink:BiologicalProcess negative regulation of cell adhesion involved in sprouting angiogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0106089 GO:0106088 biolink:BiologicalProcess regulation of cell adhesion involved in sprouting angiogenesis Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0106088 GO:0106092 biolink:BiologicalProcess glial cell projection elongation involved in axon ensheathment The extension of a glial cell process or projection to wrap around an axon. go.json http://purl.obolibrary.org/obo/GO_0106092 GO:0106091 biolink:BiologicalProcess glial cell projection elongation The process of creating an elongation or projection from a glial cell. go.json http://purl.obolibrary.org/obo/GO_0106091 GO:0106090 biolink:BiologicalProcess positive regulation of cell adhesion involved in sprouting angiogenesis Any process that activates or increases the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. go.json http://purl.obolibrary.org/obo/GO_0106090 GO:0106096 biolink:BiologicalProcess response to ceramide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. go.json http://purl.obolibrary.org/obo/GO_0106096 GO:0106095 biolink:CellularComponent m7G(5')pppN diphosphatase complex A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide. go.json 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme|DCS1 decapping scavenger complex|M(7)G(5')pppN pyrophosphatase enzyme|m7G(5')pppN diphosphatase enzyme|m7G(5')pppN pyrophosphatase enzyme http://purl.obolibrary.org/obo/GO_0106095 GO:0106094 biolink:CellularComponent nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules. go.json http://purl.obolibrary.org/obo/GO_0106094 GO:0106093 biolink:CellularComponent EDS1 disease-resistance complex A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes. go.json EDS1-PAD4 complex|EDS1-PAD4-SAG101 complex|EDS1-SAG101 complex http://purl.obolibrary.org/obo/GO_0106093 GO:0106099 biolink:MolecularActivity 2-keto-3-deoxy-L-rhamnonate aldolase activity Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde. EC:4.1.2.53|RHEA:25784 go.json http://purl.obolibrary.org/obo/GO_0106099 GO:0106098 biolink:CellularComponent NAGS/NAGK complex A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate. go.json http://purl.obolibrary.org/obo/GO_0106098 GO:0106097 biolink:BiologicalProcess cellular response to ceramide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. go.json http://purl.obolibrary.org/obo/GO_0106097 GO:0047405 biolink:MolecularActivity pyrimidine-5'-nucleotide nucleosidase activity Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine. EC:3.2.2.10|MetaCyc:3.2.2.10-RXN|RHEA:13425 go.json Pyr5N activity|pyrimidine nucleotide N-ribosidase activity|pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity http://purl.obolibrary.org/obo/GO_0047405 GO:0047404 biolink:MolecularActivity glucuronosyl-disulfoglucosamine glucuronidase activity Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine. EC:3.2.1.56|MetaCyc:RXN-16484|RHEA:15073 go.json 3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity|3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity|glucuronosyl-disulphoglucosamine glucuronidase activity http://purl.obolibrary.org/obo/GO_0047404 GO:0047403 biolink:MolecularActivity lacto-N-biosidase activity Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc. EC:3.2.1.140|RHEA:21568 go.json oligosaccharide lacto-N-biosylhydrolase activity http://purl.obolibrary.org/obo/GO_0047403 GO:0047402 biolink:MolecularActivity protein-glucosylgalactosylhydroxylysine glucosidase activity Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. EC:3.2.1.107|MetaCyc:3.2.1.107-RXN|RHEA:11068 go.json 2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity|protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity http://purl.obolibrary.org/obo/GO_0047402 GO:0047401 biolink:MolecularActivity trithionate hydrolase activity Catalysis of the reaction: H2O + trithionate = H+ + sulfate + thiosulfate. EC:3.12.1.1|KEGG_REACTION:R01930|MetaCyc:3.12.1.1-RXN|RHEA:21884 go.json trithionate thiosulfohydrolase activity http://purl.obolibrary.org/obo/GO_0047401 GO:0047400 biolink:MolecularActivity phosphonoacetate hydrolase activity Catalysis of the reaction: H2O + phosphonoacetate = acetate + H+ + phosphate. EC:3.11.1.2|KEGG_REACTION:R00318|MetaCyc:3.11.1.2-RXN|RHEA:16749 go.json phosphonoacetate phosphonohydrolase activity http://purl.obolibrary.org/obo/GO_0047400 GO:0047409 biolink:MolecularActivity alkenylglycerophosphoethanolamine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde. EC:3.3.2.5|MetaCyc:3.3.2.5-RXN|RHEA:16905 go.json 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity http://purl.obolibrary.org/obo/GO_0047409 GO:0047408 biolink:MolecularActivity alkenylglycerophosphocholine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. EC:3.3.2.2|MetaCyc:3.3.2.2-RXN|RHEA:22544 go.json 1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity|lysoplasmalogenase activity http://purl.obolibrary.org/obo/GO_0047408 GO:0047407 biolink:MolecularActivity ADP-ribosyl-[dinitrogen reductase] hydrolase activity Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]. EC:3.2.2.24|MetaCyc:3.2.2.24-RXN|RHEA:14493 go.json ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity|ADP-ribosyl glycohydrolase activity|ADP-ribosyl-dinitrogen reductase hydrolase activity|azoferredoxin glycosidase activity|azoferredoxin-activating enzymes|dinitrogenase reductase activating glycohydrolase activity|dinitrogenase reductase-activating glycohydrolase activity http://purl.obolibrary.org/obo/GO_0047407 GO:0047406 biolink:MolecularActivity beta-aspartyl-N-acetylglucosaminidase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine. EC:3.2.2.11|KEGG_REACTION:R01266|MetaCyc:3.2.2.11-RXN|RHEA:12324 go.json 1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity|beta-aspartylacetylglucosaminidase activity http://purl.obolibrary.org/obo/GO_0047406 GO:0180021 biolink:MolecularActivity snRNA 2'-O-ribose methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + snRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide. go.json http://purl.obolibrary.org/obo/GO_0180021 GO:0180020 biolink:MolecularActivity membrane bending activity The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets. go.json membrane curving http://purl.obolibrary.org/obo/GO_0180020 GO:0180012 biolink:BiologicalProcess co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway Any process involved in transcription termination-coupled 3' processing of RNA polymerase II RNA transcripts by 3' end cleavage and addition of a poly(A) tail. This pathway is required for the maturation of primary protein-encoding transcripts into functional RNAs that can be exported from the nucleus and translated in the cytoplasm, but is also required for polyadenylation-dependent decay. PMID:31499460 go.json cotranscriptional 3'-end processing of RNA polymerase II transcripts http://purl.obolibrary.org/obo/GO_0180012 GO:0180011 biolink:BiologicalProcess cytoplasmic polyadenylation Any process by which dormant, translationally inactive mRNAs become activated via the elongation of their poly(A) tails in the cytosol. go.json http://purl.obolibrary.org/obo/GO_0180011 GO:0180014 biolink:MolecularActivity protein-tRNA adaptor activity The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way. go.json tRNA carrier http://purl.obolibrary.org/obo/GO_0180014 GO:0180013 biolink:MolecularActivity lysophosphatidylserine flippase activity Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json http://purl.obolibrary.org/obo/GO_0180013 GO:0180016 biolink:MolecularActivity SUMO ligase regulator activity Binds to and modulates the activity of a SUMO ligase. go.json http://purl.obolibrary.org/obo/GO_0180016 GO:0180015 biolink:BiologicalProcess nucleoside import across plasma membrane The directed movement of nucleoside from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0180015 GO:0180018 biolink:BiologicalProcess cytoplasmic polyadenylation-dependent RNA catabolic process The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate. go.json http://purl.obolibrary.org/obo/GO_0180018 GO:0180017 biolink:MolecularActivity K11-linked deubiquitinase activity Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin. go.json http://purl.obolibrary.org/obo/GO_0180017 GO:0180019 biolink:CellularComponent Knl1/Spc105 complex A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans and yeast respectively, it consists of KNL1/Spc105p and ZWINT/Kre28p. go.json http://purl.obolibrary.org/obo/GO_0180019 GO:0180010 biolink:BiologicalProcess co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway Any process involved in transcription termination-coupled 3' processing of RNA polymerase II mRNA transcripts by the 3' end cleavage and addition of a poly(A) tail. This pathway is required for the maturation of primary protein-encoding transcripts into functional mRNAs that can be exported from the nucleus and translated in the cytoplasm, but is also required for polyadenylation-dependent decay. go.json cotranscriptional 3' processing of RNA polymerase II mRNA transcripts http://purl.obolibrary.org/obo/GO_0180010 GO:0047375 biolink:MolecularActivity N-acetylgalactosaminoglycan deacetylase activity Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan. EC:3.1.1.58|MetaCyc:3.1.1.58-RXN go.json N-acetyl galactosaminoglycan deacetylase activity|N-acetyl-D-galactosaminoglycan acetylhydrolase activity|Vi-polysaccharide deacetylase activity|polysaccharide deacetylase activity http://purl.obolibrary.org/obo/GO_0047375 GO:0072331 biolink:BiologicalProcess signal transduction by p53 class mediator An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. go.json http://purl.obolibrary.org/obo/GO_0072331 GO:0072330 biolink:BiologicalProcess monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. go.json monocarboxylic acid anabolism|monocarboxylic acid biosynthesis|monocarboxylic acid formation|monocarboxylic acid synthesis http://purl.obolibrary.org/obo/GO_0072330 GO:0047374 biolink:MolecularActivity methylumbelliferyl-acetate deacetylase activity Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+. EC:3.1.1.56|KEGG_REACTION:R04141|MetaCyc:3.1.1.56-RXN|RHEA:12208 go.json 4-methylumbelliferyl-acetate acylhydrolase activity|esterase D activity http://purl.obolibrary.org/obo/GO_0047374 GO:0047373 biolink:MolecularActivity acetoxybutynylbithiophene deacetylase activity Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H+. EC:3.1.1.54|KEGG_REACTION:R04490|MetaCyc:3.1.1.54-RXN|RHEA:11548 go.json 5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity|5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity|acetoxybutynylbithiophene esterase activity http://purl.obolibrary.org/obo/GO_0047373 GO:0047372 biolink:MolecularActivity acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. EC:3.1.1.23|MetaCyc:3.1.1.23-RXN|RHEA:34019|Reactome:R-HSA-1482543|Reactome:R-HSA-163595|Reactome:R-HSA-192422|Reactome:R-HSA-192425|Reactome:R-HSA-192430|Reactome:R-HSA-192434|Reactome:R-HSA-192475|Reactome:R-HSA-426032|Reactome:R-HSA-426043|Reactome:R-HSA-5694462 go.json fatty acyl monoester lipase activity|glycerol-ester acylhydrolase activity|monoacylglycerol hydrolase activity|monoacylglycerol lipase activity|monoacylglycerolipase activity|monoglyceridase activity|monoglyceride hydrolase activity|monoglyceride lipase activity|monoglyceridyllipase activity http://purl.obolibrary.org/obo/GO_0047372 goslim_chembl GO:0047371 biolink:MolecularActivity butyrate-acetoacetate CoA-transferase activity Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate. EC:2.8.3.9|KEGG_REACTION:R01365|MetaCyc:2.8.3.9-RXN|RHEA:12961 go.json butanoyl-CoA:acetoacetate CoA-transferase activity|butyryl coenzyme A-acetoacetate coenzyme A-transferase activity|butyryl-CoA-acetoacetate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0047371 GO:0047370 biolink:MolecularActivity succinate-citramalate CoA-transferase activity Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate. MetaCyc:2.8.3.7-RXN|RHEA:38287 go.json citramalate coenzyme A-transferase activity|itaconate CoA-transferase activity|succinyl coenzyme A-citramalyl coenzyme A transferase activity|succinyl-CoA:citramalate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0047370 GO:0047379 biolink:MolecularActivity ADP-dependent short-chain-acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA. EC:3.1.2.18|MetaCyc:3.1.2.18-RXN go.json ADP-dependent propionyl coenzyme A hydrolase activity|ADP-dependent propionyl-CoA hydrolase activity|ADP-dependent propionyl-CoA thioesterase activity|ADP-dependent short-chain acyl coenzyme A hydrolase activity|ADP-dependent short-chain acyl-CoA hydrolase activity|ADP-dependent short-chain acyl-CoA thioesterase activity|ADP-dependent-short-chain-acyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0047379 GO:0047378 biolink:MolecularActivity acetylalkylglycerol acetylhydrolase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+. EC:3.1.1.71|KEGG_REACTION:R04043|MetaCyc:3.1.1.71-RXN|RHEA:11552 go.json 2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity|alkylacetylglycerol acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0047378 GO:0047377 biolink:MolecularActivity 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H+. EC:3.1.1.66|KEGG_REACTION:R04525|MetaCyc:3.1.1.66-RXN|RHEA:16313 go.json 3,4-diacetoxybutinylbithiophene:4-acetate esterase activity|5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity|diacetoxybutynylbithiophene acetate esterase activity http://purl.obolibrary.org/obo/GO_0047377 GO:0047376 biolink:MolecularActivity all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate. KEGG_REACTION:R02368|MetaCyc:3.1.1.64-RXN|RHEA:13933|Reactome:R-HSA-2404140|Reactome:R-HSA-2429643 go.json all-trans-retinyl-palmitate acylhydrolase activity|all-trans-retinyl-palmitate hydrolase activity|retinyl-palmitate palmitohydrolase activity http://purl.obolibrary.org/obo/GO_0047376 GO:0072339 biolink:BiologicalProcess lactam biosynthetic process The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. go.json cellular lactam anabolism|cellular lactam biosynthesis|cellular lactam biosynthetic process|cellular lactam formation|cellular lactam synthesis http://purl.obolibrary.org/obo/GO_0072339 GO:0072338 biolink:BiologicalProcess lactam metabolic process The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. go.json cellular lactam metabolic process|cellular lactam metabolism http://purl.obolibrary.org/obo/GO_0072338 GO:0072337 biolink:BiologicalProcess modified amino acid transport The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json amino acid derivative transport http://purl.obolibrary.org/obo/GO_0072337 GO:0072336 biolink:BiologicalProcess negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation|negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation|negative regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation http://purl.obolibrary.org/obo/GO_0072336 GO:0072335 biolink:BiologicalProcess regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation|regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation|regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation http://purl.obolibrary.org/obo/GO_0072335 GO:0072334 biolink:BiologicalProcess UDP-galactose transmembrane transport The process in which UDP-galactose is transported across a membrane. go.json UDP-galactose membrane transport|UDP-galactose transport http://purl.obolibrary.org/obo/GO_0072334 GO:0072333 biolink:BiologicalProcess obsolete anoikis by p53 class mediator OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of anoikis. go.json anoikis by p53 class mediator|anoikis by signal transduction by p53 class mediator|signal transduction by p53 class mediator resulting in induction of anoikis True http://purl.obolibrary.org/obo/GO_0072333 GO:0072332 biolink:BiologicalProcess intrinsic apoptotic signaling pathway by p53 class mediator The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. go.json intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_0072332 GO:0072320 biolink:MolecularActivity volume-sensitive chloride channel activity Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. go.json swell-activated chloride channel http://purl.obolibrary.org/obo/GO_0072320 GO:0047386 biolink:MolecularActivity fructose-2,6-bisphosphate 6-phosphatase activity Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate. EC:3.1.3.54|KEGG_REACTION:R02730|MetaCyc:3.1.3.54-RXN|RHEA:13333 go.json D-fructose-2,6-bisphosphate 6-phosphohydrolase activity|beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity|fructose 2,6-bisphosphate-6-phosphohydrolase activity|fructose-2,6-bisphosphate 6-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047386 GO:0047385 biolink:MolecularActivity [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity Catalysis of the reaction: H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate. EC:3.1.3.52|MetaCyc:3.1.3.52-RXN go.json branched-chain 2-keto acid dehydrogenase phosphatase activity|branched-chain alpha-keto acid dehydrogenase phosphatase|branched-chain oxo-acid dehydrogenase phosphatase activity http://purl.obolibrary.org/obo/GO_0047385 GO:0047384 biolink:MolecularActivity [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]. EC:3.1.3.47|MetaCyc:3.1.3.47-RXN go.json hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity|hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity|reductase phosphatase activity http://purl.obolibrary.org/obo/GO_0047384 GO:0047383 biolink:MolecularActivity guanidinodeoxy-scyllo-inositol-4-phosphatase activity Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate. EC:3.1.3.40|KEGG_REACTION:R03496|MetaCyc:3.1.3.40-RXN|RHEA:15777 go.json 1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity|1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity|1-guanidino-scyllo-inositol 4-phosphatase activity http://purl.obolibrary.org/obo/GO_0047383 GO:0047382 biolink:MolecularActivity methylphosphothioglycerate phosphatase activity Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate. EC:3.1.3.14|KEGG_REACTION:R04317|MetaCyc:3.1.3.14-RXN|RHEA:16081 go.json S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity|methylthiophosphoglycerate phosphatase activity http://purl.obolibrary.org/obo/GO_0047382 GO:0047381 biolink:MolecularActivity dodecanoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: dodecanoyl-[ACP] + H2O = dodecanoate + H+ + holo-[ACP]. EC:3.1.2.21|MetaCyc:3.1.2.21-RXN|RHEA:30119 go.json dodecanoyl-ACP hydrolase activity|dodecanoyl-[acyl-carrier protein] hydrolase activity|dodecanoyl-acyl-carrier-protein hydrolase activity|dodecyl-[acyl-carrier protein] hydrolase activity|dodecyl-acyl-carrier protein hydrolase|lauroyl-ACP hydrolase activity|lauroyl-[acyl-carrier-protein] hydrolase activity|lauryl-[acyl-carrier protein] hydrolase activity|lauryl-acyl-carrier protein hydrolase activity|lauryl-acyl-carrier-protein hydrolase activity http://purl.obolibrary.org/obo/GO_0047381 GO:0047380 biolink:MolecularActivity ADP-dependent medium-chain-acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP. EC:3.1.2.19|MetaCyc:3.1.2.19-RXN go.json ADP-dependent medium-chain acyl coenzyme A hydrolase activity|ADP-dependent medium-chain acyl-CoA hydrolase activity|ADP-dependent medium-chain acyl-thioester hydrolase activity|ADP-dependent medium-chain hydrolase activity|ADP-dependent myristoyl-CoA thioesterase activity|ADP-dependent-medium-chain-acyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0047380 GO:0047389 biolink:MolecularActivity glycerophosphocholine phosphodiesterase activity Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. EC:3.1.4.2|MetaCyc:3.1.4.2-RXN|RHEA:16061|Reactome:R-HSA-6814132 go.json glycerolphosphorylcholine phosphodiesterase activity|glycerophosphinicocholine diesterase activity|glycerophosphohydrolase activity|glycerylphosphorylcholinediesterase activity|sn-glycero-3-phosphocholine glycerophosphohydrolase activity|sn-glycero-3-phosphorylcholine diesterase activity http://purl.obolibrary.org/obo/GO_0047389 GO:0047388 biolink:MolecularActivity [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity Catalysis of the reaction: [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP. EC:2.7.7.89|KEGG_REACTION:R03474|MetaCyc:GSDEADENYLATION-RXN|RHEA:43716 go.json [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase|adenylyl(glutamine synthetase) hydrolase activity|adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity|adenylyl-[glutamate-ammonia ligase] hydrolase activity|adenylyl-glutamate-ammonia ligase hydrolase activity|adenylyl-glutamine-synthetasehydrolase activity http://purl.obolibrary.org/obo/GO_0047388 GO:0047387 biolink:MolecularActivity serine-ethanolaminephosphate phosphodiesterase activity Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine. EC:3.1.4.13|KEGG_REACTION:R02817|MetaCyc:3.1.4.13-RXN|RHEA:17113 go.json SEP diesterase activity|serine ethanolamine phosphodiester phosphodiesterase activity|serine-phosphoethanolamine ethanolaminephosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047387 GO:0072329 biolink:BiologicalProcess monocarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. go.json http://purl.obolibrary.org/obo/GO_0072329 GO:0072328 biolink:MolecularActivity alkene binding Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. go.json http://purl.obolibrary.org/obo/GO_0072328 GO:0072327 biolink:BiologicalProcess vulval cell fate specification The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. go.json http://purl.obolibrary.org/obo/GO_0072327 GO:0072326 biolink:BiologicalProcess vulval cell fate determination The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. go.json http://purl.obolibrary.org/obo/GO_0072326 GO:0072325 biolink:BiologicalProcess vulval cell fate commitment The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. go.json http://purl.obolibrary.org/obo/GO_0072325 GO:0072324 biolink:CellularComponent ascus epiplasm Ascus cytoplasm that is not packaged into ascospores. go.json http://purl.obolibrary.org/obo/GO_0072324 GO:0072323 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072323 GO:0072322 biolink:BiologicalProcess protein transport across periplasmic space The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall. go.json chaperone-mediated protein transport across periplasmic space http://purl.obolibrary.org/obo/GO_0072322 GO:0072321 biolink:BiologicalProcess obsolete chaperone-mediated protein transport OBSOLETE. The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins. go.json True http://purl.obolibrary.org/obo/GO_0072321 GO:0047397 biolink:MolecularActivity dolichylphosphate-glucose phosphodiesterase activity Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose. EC:3.1.4.48|MetaCyc:3.1.4.48-RXN|RHEA:13857 go.json Dol-P-Glc phosphodiesterase activity|dolichol phosphoglucose phosphodiesterase activity|dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity|dolichyl-phosphate-glucose phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0047397 GO:0072353 biolink:BiologicalProcess obsolete cellular age-dependent response to reactive oxygen species OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. go.json True http://purl.obolibrary.org/obo/GO_0072353 GO:0047396 biolink:MolecularActivity glycosylphosphatidylinositol diacylglycerol-lyase activity Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate. EC:4.6.1.14|MetaCyc:3.1.4.47-RXN|RHEA:14333 go.json (glycosyl)phosphatidylinositol-specific phospholipase C activity|6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]|6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity|GPI-PLC activity|GPI-specific phospholipase C activity|VSG-lipase activity|glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity|glycosylphosphatidylinositol-phospholipase C activity|glycosylphosphatidylinositol-specific phospholipase C activity|variant-surface-glycoprotein phospholipase C activity http://purl.obolibrary.org/obo/GO_0047396 GO:0072352 biolink:BiologicalProcess tricarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups. go.json tricarboxylate catabolic process|tricarboxylate catabolism|tricarboxylic acid breakdown|tricarboxylic acid catabolism|tricarboxylic acid degradation http://purl.obolibrary.org/obo/GO_0072352 GO:0047395 biolink:MolecularActivity glycerophosphoinositol glycerophosphodiesterase activity Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+. EC:3.1.4.44|KEGG_REACTION:R01193|MetaCyc:3.1.4.44-RXN|RHEA:16501|Reactome:R-HSA-6813740 go.json 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity|sn-glycero(3)phosphoinositol glycerophosphohydrolase activity|sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047395 GO:0072351 biolink:BiologicalProcess tricarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups. go.json tricarboxylate biosynthesis|tricarboxylate biosynthetic process|tricarboxylic acid anabolism|tricarboxylic acid biosynthesis|tricarboxylic acid formation|tricarboxylic acid synthesis http://purl.obolibrary.org/obo/GO_0072351 GO:0072350 biolink:BiologicalProcess tricarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). go.json tricarboxylic acid metabolism http://purl.obolibrary.org/obo/GO_0072350 GO:0047394 biolink:MolecularActivity glycerophosphoinositol inositolphosphodiesterase activity Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. EC:3.1.4.43|MetaCyc:3.1.4.43-RXN|RHEA:14033 go.json 1,2-cyclic-inositol-phosphate phosphodiesterase activity|1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity|1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity|D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity|D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity|D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity|inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047394 GO:0047393 biolink:MolecularActivity glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+. EC:3.1.4.42|KEGG_REACTION:R02648|MetaCyc:3.1.4.42-RXN|RHEA:16493 go.json rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity|rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047393 GO:0047392 biolink:MolecularActivity CMP-N-acylneuraminate phosphodiesterase activity Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP. EC:3.1.4.40|MetaCyc:3.1.4.40-RXN|RHEA:20185 go.json CMP-N-acetylneuraminate hydrolase activity|CMP-N-acylneuraminate N-acylneuraminohydrolase activity|CMP-N-acylneuraminic acid hydrolase activity|CMP-sialate hydrolase activity|CMP-sialic acid hydrolase activity|cytidine monophosphate-N-acetylneuraminic acid hydrolase activity|cytidine monophosphosialate hydrolase activity|cytidine monophosphosialic hydrolase activity http://purl.obolibrary.org/obo/GO_0047392 GO:0047391 biolink:MolecularActivity alkylglycerophosphoethanolamine phosphodiesterase activity Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. EC:3.1.4.39|MetaCyc:3.1.4.39-RXN|RHEA:15965 go.json 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity|lysophospholipase D activity http://purl.obolibrary.org/obo/GO_0047391 GO:0047390 biolink:MolecularActivity glycerophosphocholine cholinephosphodiesterase activity Catalysis of the reaction: sn-glycero-3-phosphocholine + H2O = choline phosphate + glycerol + H+. EC:3.1.4.38|KEGG_REACTION:R02591|MetaCyc:3.1.4.38-RXN|RHEA:19545|Reactome:R-HSA-6814797 go.json L-3-glycerylphosphinicocholine cholinephosphohydrolase activity|sn-glycero-3-phosphocholine cholinephosphohydrolase activity http://purl.obolibrary.org/obo/GO_0047390 GO:0047399 biolink:MolecularActivity glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate. EC:3.1.4.51|MetaCyc:3.1.4.51-RXN|RHEA:18045 go.json 6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity|alpha-glucose-1-phosphate phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0047399 GO:0047398 biolink:MolecularActivity dolichylphosphate-mannose phosphodiesterase activity Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose. EC:3.1.4.49|MetaCyc:3.1.4.49-RXN|RHEA:12989 go.json dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity|mannosylphosphodolichol phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0047398 GO:0072359 biolink:BiologicalProcess circulatory system development The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. go.json cardiovascular system development http://purl.obolibrary.org/obo/GO_0072359 goslim_drosophila GO:0072358 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072358 GO:0072357 biolink:CellularComponent PTW/PP1 phosphatase complex A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. go.json http://purl.obolibrary.org/obo/GO_0072357 GO:0072356 biolink:BiologicalProcess chromosome passenger complex localization to kinetochore A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. go.json CPC complex localization to kinetochore|CPC localization to kinetochore|chromosomal passenger complex localization to kinetochore|chromosome passenger complex localisation to kinetochore http://purl.obolibrary.org/obo/GO_0072356 GO:0072355 biolink:BiologicalProcess obsolete histone H3-T3 phosphorylation OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone. go.json True http://purl.obolibrary.org/obo/GO_0072355 GO:0072354 biolink:MolecularActivity histone H3T3 kinase activity Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3. go.json histone H3-T3 kinase activity|histone kinase activity (H3-T3 specific)|histone threonine kinase activity (H3-T3 specific)|histone-threonine kinase activity (H3-T3 specific) http://purl.obolibrary.org/obo/GO_0072354 GO:0106100 biolink:MolecularActivity beta-pinacene synthase activity Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene. go.json http://purl.obolibrary.org/obo/GO_0106100 GO:0072342 biolink:BiologicalProcess response to anion stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment. go.json http://purl.obolibrary.org/obo/GO_0072342 GO:0072341 biolink:MolecularActivity modified amino acid binding Binding to a modified amino acid. go.json amino acid derivative binding http://purl.obolibrary.org/obo/GO_0072341 GO:0072340 biolink:BiologicalProcess lactam catabolic process The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. go.json cellular lactam breakdown|cellular lactam catabolic process|cellular lactam catabolism|cellular lactam degradation http://purl.obolibrary.org/obo/GO_0072340 GO:0106104 biolink:BiologicalProcess regulation of glutamate receptor clustering Any process that modulates the frequency, rate or extent of glutamate receptor clustering. go.json http://purl.obolibrary.org/obo/GO_0106104 GO:0106103 biolink:CellularComponent COPII vesicles tethering complex A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae. go.json Bug1-Grh1 complex|GRASP65-GM130 complex http://purl.obolibrary.org/obo/GO_0106103 GO:0106101 biolink:BiologicalProcess ER-dependent peroxisome localization A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0106101 GO:0106108 biolink:BiologicalProcess negative regulation of (R)-mevalonic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of (R)-mevalonic acid biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0106108 GO:0106107 biolink:BiologicalProcess regulation of (R)-mevalonic acid biosynthetic process Any process that modulates the frequency, rate or extent of (R)-mevalonic acid biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0106107 GO:0106106 biolink:BiologicalProcess cold-induced thermogenesis The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature. go.json CIT http://purl.obolibrary.org/obo/GO_0106106 GO:0106105 biolink:MolecularActivity Ala-tRNA(Thr) hydrolase activity Catalysis of the hydrolysis of misacylated ala-tRNA(thr). go.json L-alanyl-tRNA(Thr) deacylase http://purl.obolibrary.org/obo/GO_0106105 GO:0106109 biolink:BiologicalProcess positive regulation of (R)-mevalonic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of (R)-mevalonic acid biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0106109 GO:0072349 biolink:MolecularActivity modified amino acid transmembrane transporter activity Enables the transfer of modified amino acids from one side of a membrane to the other. go.json amino acid derivative transmembrane transporter activity|modified amino acid transporter activity http://purl.obolibrary.org/obo/GO_0072349 GO:0072348 biolink:BiologicalProcess sulfur compound transport The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json sulfur-containing compound transport http://purl.obolibrary.org/obo/GO_0072348 GO:0072347 biolink:BiologicalProcess response to anesthetic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation. go.json response to anaesthetic http://purl.obolibrary.org/obo/GO_0072347 GO:0072346 biolink:MolecularActivity cADPR-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0072346 GO:0072345 biolink:MolecularActivity NAADP-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. Reactome:R-HSA-2685505 go.json http://purl.obolibrary.org/obo/GO_0072345 GO:0072344 biolink:BiologicalProcess rescue of stalled ribosome A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex. go.json http://purl.obolibrary.org/obo/GO_0072344 GO:0072343 biolink:BiologicalProcess pancreatic stellate cell proliferation The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus. go.json http://purl.obolibrary.org/obo/GO_0072343 GO:0072375 biolink:BiologicalProcess medium-term memory The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster). go.json MTM|middle-term memory http://purl.obolibrary.org/obo/GO_0072375 GO:0072374 biolink:MolecularActivity carotene epsilon hydroxylase activity Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. go.json http://purl.obolibrary.org/obo/GO_0072374 GO:0072373 biolink:MolecularActivity alpha-carotene epsilon hydroxylase activity Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0072373 GO:0072372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072372 GO:0072371 biolink:MolecularActivity histone H2AS121 kinase activity Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A. go.json histone H2A-S121 kinase activity|histone kinase activity (H2A-S121 specific)|histone serine kinase activity (H2A-S121 specific)|histone-serine kinase activity (H2A-S121 specific) http://purl.obolibrary.org/obo/GO_0072371 GO:0072370 biolink:BiologicalProcess obsolete histone H2A-S121 phosphorylation OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone. go.json histone H2A phosphorylation at S121|histone H2AS121 phosphorylation True http://purl.obolibrary.org/obo/GO_0072370 GO:0072379 biolink:CellularComponent ER membrane insertion complex A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast. go.json endoplasmic reticulum membrane insertion complex http://purl.obolibrary.org/obo/GO_0072379 GO:0072378 biolink:BiologicalProcess blood coagulation, fibrin clot formation A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. go.json http://purl.obolibrary.org/obo/GO_0072378 GO:0072377 biolink:BiologicalProcess blood coagulation, common pathway A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex. go.json http://purl.obolibrary.org/obo/GO_0072377 GO:0072376 biolink:BiologicalProcess protein activation cascade A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events. go.json protein activation pathway|protein activitory cascade http://purl.obolibrary.org/obo/GO_0072376 GO:0072364 biolink:BiologicalProcess obsolete regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter|regulation of cellular ketone metabolism by regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072364 GO:0072363 biolink:BiologicalProcess obsolete regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072363 GO:0072362 biolink:BiologicalProcess obsolete regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072362 GO:0072361 biolink:BiologicalProcess obsolete regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0072361 GO:0072360 biolink:BiologicalProcess vascular cord development The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. go.json http://purl.obolibrary.org/obo/GO_0072360 GO:0072369 biolink:BiologicalProcess obsolete regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072369 GO:0072368 biolink:BiologicalProcess obsolete regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072368 GO:0072367 biolink:BiologicalProcess obsolete regulation of lipid transport by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072367 GO:0072366 biolink:BiologicalProcess obsolete regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of cellular ketone metabolism by positive regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072366 GO:0072365 biolink:BiologicalProcess obsolete regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|regulation of cellular ketone metabolism by negative regulation of transcription from an RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0072365 GO:0072397 biolink:BiologicalProcess obsolete detection of stimulus involved in cytokinesis checkpoint OBSOLETE. The series of events in which information about the formation and integrity of cytokinetic structures, such as the contractile ring, is received and converted into a molecular signal, contributing to a cytokinesis checkpoint. go.json cytokinesis checkpoint sensor mechanism|cytokinesis checkpoint sensor process|detection of stimulus involved in septin checkpoint|sensing involved in cytokinesis checkpoint|sensing involved in septin checkpoint|septin checkpoint sensor mechanism|septin checkpoint sensor process True http://purl.obolibrary.org/obo/GO_0072397 GO:0072396 biolink:BiologicalProcess response to cell cycle checkpoint signaling A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling. go.json G1/S transition checkpoint effector process|G2/M transition checkpoint effector process|cell cycle checkpoint effector process|response to G1/S transition checkpoint signaling|response to G2/M transition checkpoint signaling|response to signal involved in G1/S transition checkpoint|response to signal involved in G2/M transition checkpoint|response to signal involved in cell cycle checkpoint http://purl.obolibrary.org/obo/GO_0072396 GO:0072395 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0072395 GO:0072394 biolink:BiologicalProcess obsolete detection of stimulus involved in cell cycle checkpoint OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint. go.json G1/S transition checkpoint sensor mechanism|G1/S transition checkpoint sensor process|G2/M transition checkpoint sensor mechanism|G2/M transition checkpoint sensor process|cell cycle checkpoint sensor mechanism|cell cycle checkpoint sensor process|detection of stimulus involved in G1/S transition checkpoint|detection of stimulus involved in G2/M transition checkpoint|sensing involved in G1/S transition checkpoint|sensing involved in G2/M transition checkpoint|sensing involved in cell cycle checkpoint True http://purl.obolibrary.org/obo/GO_0072394 GO:0072393 biolink:BiologicalProcess microtubule anchoring at microtubule organizing center Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center. go.json microtubule anchoring at MTOC|microtubule anchoring at microtubule organising centre http://purl.obolibrary.org/obo/GO_0072393 GO:0072392 biolink:BiologicalProcess phenol catabolic process The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group. go.json http://purl.obolibrary.org/obo/GO_0072392 GO:0072391 biolink:BiologicalProcess phenol biosynthetic process The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group. go.json http://purl.obolibrary.org/obo/GO_0072391 GO:0072390 biolink:BiologicalProcess phenol metabolic process The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group. go.json http://purl.obolibrary.org/obo/GO_0072390 GO:0072399 biolink:BiologicalProcess response to cytokinesis checkpoint signaling A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling. go.json cytokinesis checkpoint effector process|response to signal involved in cytokinesis checkpoint http://purl.obolibrary.org/obo/GO_0072399 GO:0072398 biolink:BiologicalProcess signal transduction involved in cytokinesis checkpoint A signal transduction process that contributes to a cytokinesis checkpoint. go.json http://purl.obolibrary.org/obo/GO_0072398 GO:0072386 biolink:BiologicalProcess plus-end-directed organelle transport along microtubule The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. go.json microtubule plus-end-directed organelle distribution|microtubule plus-end-directed organelle localization http://purl.obolibrary.org/obo/GO_0072386 GO:0072385 biolink:BiologicalProcess minus-end-directed organelle transport along microtubule The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. go.json microtubule minus-end-directed organelle distribution|microtubule minus-end-directed organelle localization http://purl.obolibrary.org/obo/GO_0072385 GO:0072384 biolink:BiologicalProcess organelle transport along microtubule The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. go.json microtubule-based organelle localization http://purl.obolibrary.org/obo/GO_0072384 GO:0072383 biolink:BiologicalProcess plus-end-directed vesicle transport along microtubule The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. go.json microtubule plus-end-directed vesicle distribution|microtubule plus-end-directed vesicle localization http://purl.obolibrary.org/obo/GO_0072383 GO:0072382 biolink:BiologicalProcess minus-end-directed vesicle transport along microtubule The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. go.json microtubule minus-end-directed vesicle distribution|microtubule minus-end-directed vesicle localization http://purl.obolibrary.org/obo/GO_0072382 GO:0072381 biolink:BiologicalProcess positive regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. go.json positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation|positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation|positive regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation http://purl.obolibrary.org/obo/GO_0072381 GO:0072380 biolink:CellularComponent TRC complex A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane. go.json GET4-GET5 transmembrane domain recognition complex|TMD recognition complex http://purl.obolibrary.org/obo/GO_0072380 GO:0072389 biolink:BiologicalProcess flavin adenine dinucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. go.json FAD or FADH2 catabolic process|flavin adenine dinucleotide breakdown|flavin adenine dinucleotide catabolism|flavin adenine dinucleotide degradation http://purl.obolibrary.org/obo/GO_0072389 GO:0072388 biolink:BiologicalProcess flavin adenine dinucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. go.json FAD or FADH2 biosynthetic process|flavin adenine dinucleotide anabolism|flavin adenine dinucleotide biosynthesis|flavin adenine dinucleotide formation|flavin adenine dinucleotide synthesis http://purl.obolibrary.org/obo/GO_0072388 GO:0072387 biolink:BiologicalProcess flavin adenine dinucleotide metabolic process The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. go.json FAD or FADH2 metabolic process|flavin adenine dinucleotide metabolism|flavin-adenine dinucleotide metabolic process http://purl.obolibrary.org/obo/GO_0072387 GO:0106155 biolink:MolecularActivity peptidyl-lysine 3-dioxygenase activity Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2. EC:1.14.11.63|RHEA:57152|Reactome:R-HSA-9629578|Reactome:R-HSA-9629591 go.json http://purl.obolibrary.org/obo/GO_0106155 GO:0106154 biolink:BiologicalProcess perithecium formation The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck. go.json http://purl.obolibrary.org/obo/GO_0106154 GO:0106153 biolink:MolecularActivity phosphorylated histone binding Binding to a histone in which a residue has been modified by phosphorylation. go.json http://purl.obolibrary.org/obo/GO_0106153 GO:0106159 biolink:BiologicalProcess obsolete regulation of small RNA loading onto RISC OBSOLETE. Any process that modulates the frequency, rate or extent small RNA loading onto RISC. go.json True http://purl.obolibrary.org/obo/GO_0106159 GO:0106158 biolink:MolecularActivity glycero-3-phosphocholine acyltransferase activity Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine. RHEA:58476 go.json GPACT activity|glycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0106158 GO:0106157 biolink:MolecularActivity peptidyl-arginine 3-dioxygenase activity Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate. EC:1.14.11.73|RHEA:56744|Reactome:R-HSA-9629869|Reactome:R-HSA-9629888 go.json L-arginine 3-hydroxylase activity http://purl.obolibrary.org/obo/GO_0106157 GO:0106156 biolink:MolecularActivity peptidyl-lysine 4-dioxygenase activity Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2. RHEA:57156|Reactome:R-HSA-9629946 go.json http://purl.obolibrary.org/obo/GO_0106156 GO:0106162 biolink:MolecularActivity mRNA N-acetyltransferase activity Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate. RHEA:58480 go.json http://purl.obolibrary.org/obo/GO_0106162 GO:0106161 biolink:BiologicalProcess obsolete positive regulation of small RNA loading onto RISC OBSOLETE. Any process that activates or increases the frequency, rate or extent of small RNA loading onto RISC. go.json True http://purl.obolibrary.org/obo/GO_0106161 GO:0106160 biolink:BiologicalProcess obsolete negative regulation of small RNA loading onto RISC OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of small RNA loading onto RISC. go.json True http://purl.obolibrary.org/obo/GO_0106160 GO:0106166 biolink:MolecularActivity spindle pole body-nuclear membrane anchor activity The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body. go.json nuclear membrane-spindle pole body anchor activity|spindle pole body nuclear membrane anchor activity http://purl.obolibrary.org/obo/GO_0106166 GO:0106165 biolink:BiologicalProcess negative regulation of exonucleolytic catabolism of deadenylated mRNA Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. go.json http://purl.obolibrary.org/obo/GO_0106165 GO:0106164 biolink:BiologicalProcess positive regulation of exonucleolytic catabolism of deadenylated mRNA Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. go.json http://purl.obolibrary.org/obo/GO_0106164 GO:0106163 biolink:BiologicalProcess regulation of exonucleolytic catabolism of deadenylated mRNA Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. go.json http://purl.obolibrary.org/obo/GO_0106163 GO:0106167 biolink:BiologicalProcess extracellular ATP signaling The series of molecular signals mediated by the detection of extracellular ATP. go.json http://purl.obolibrary.org/obo/GO_0106167 GO:0047306 biolink:MolecularActivity D-methionine-pyruvate transaminase activity Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine. EC:2.6.1.41|KEGG_REACTION:R03001|MetaCyc:2.6.1.41-RXN|RHEA:23836 go.json D-methionine aminotransferase activity|D-methionine transaminase activity|D-methionine--pyruvate aminotransferase activity|D-methionine-pyruvate aminotransferase activity|D-methionine:pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047306 GO:0047305 biolink:MolecularActivity (R)-3-amino-2-methylpropionate-pyruvate transaminase activity Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine. EC:2.6.1.40|KEGG_REACTION:R02050|MetaCyc:2.6.1.40-RXN|RHEA:18393|Reactome:R-HSA-909780 go.json (R)-3-amino-2-methylpropanoate aminotransferase activity|(R)-3-amino-2-methylpropanoate transaminase activity|(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity|(R)-3-amino-2-methylpropionate transaminase activity|(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity|(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity|D-3-aminoisobutyrate--pyruvate aminotransferase activity|D-3-aminoisobutyrate--pyruvate transaminase activity|D-3-aminoisobutyrate-pyruvate transaminase activity|D-AIBAT activity|D-beta-aminoisobutyrate:pyruvate aminotransferase activity|beta-aminoisobutyrate--pyruvate transaminase activity|beta-aminoisobutyrate-pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047305 GO:0047304 biolink:MolecularActivity 2-aminoethylphosphonate-pyruvate transaminase activity Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde. EC:2.6.1.37|KEGG_REACTION:R04152|MetaCyc:2.6.1.37-RXN|RHEA:17021 go.json (2-aminoethyl)phosphonate aminotransferase activity|(2-aminoethyl)phosphonate transaminase activity|(2-aminoethyl)phosphonate--pyruvate aminotransferase activity|(2-aminoethyl)phosphonate:pyruvate aminotransferase activity|(2-aminoethyl)phosphonic acid aminotransferase activity|2-aminoethylphosphonate aminotransferase activity|2-aminoethylphosphonate--pyruvate aminotransferase activity|2-aminoethylphosphonate-pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047304 GO:0047303 biolink:MolecularActivity glycine-oxaloacetate transaminase activity Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate. EC:2.6.1.35|KEGG_REACTION:R00373|MetaCyc:2.6.1.35-RXN|RHEA:17141 go.json glycine--oxaloacetate aminotransferase activity|glycine-oxalacetate aminotransferase activity|glycine-oxaloacetate aminotransferase activity|glycine:oxaloacetate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047303 GO:0047302 biolink:MolecularActivity UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose. EC:2.6.1.34|KEGG_REACTION:R04529|MetaCyc:RXN-12812|RHEA:31663 go.json UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity|UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity|UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity|uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity http://purl.obolibrary.org/obo/GO_0047302 GO:0047301 biolink:MolecularActivity valine-3-methyl-2-oxovalerate transaminase activity Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine. EC:2.6.1.32|KEGG_REACTION:R02200|MetaCyc:2.6.1.32-RXN|RHEA:11468 go.json L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity|valine--3-methyl-2-oxovalerate aminotransferase activity|valine--isoleucine aminotransferase activity|valine--isoleucine transaminase activity|valine-2-keto-methylvalerate aminotransferase activity|valine-3-methyl-2-oxovalerate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047301 GO:0047300 biolink:MolecularActivity pyridoxamine-pyruvate transaminase activity Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal. EC:2.6.1.30|KEGG_REACTION:R01712|MetaCyc:2.6.1.30-RXN|RHEA:12841 go.json pyridoxamine--pyruvate aminotransferase activity|pyridoxamine-pyruvate aminotransferase activity|pyridoxamine-pyruvic transaminase|pyridoxamine:pyruvate aminotransferase activity|pyridoxamineu-pyruvic transaminase activity http://purl.obolibrary.org/obo/GO_0047300 GO:0047309 biolink:MolecularActivity dihydroxyphenylalanine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate. EC:2.6.1.49|KEGG_REACTION:R02077|MetaCyc:2.6.1.49-RXN|RHEA:15273 go.json 3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity|DOPA aminotransferase activity|L-dopa transaminase activity|aspartate-DOPP transaminase (ADT)|dihydroxyphenylalanine aminotransferase activity|dopa transaminase activity|glutamate-DOPP transaminase (GDT)|phenylalanine-DOPP transaminase (PDT) http://purl.obolibrary.org/obo/GO_0047309 GO:0047308 biolink:MolecularActivity alanine-oxomalonate transaminase activity Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate. EC:2.6.1.47|KEGG_REACTION:R02970|MetaCyc:2.6.1.47-RXN|RHEA:18809 go.json L-alanine-ketomalonate transaminase activity|L-alanine:oxomalonate aminotransferase activity|alanine--oxomalonate aminotransferase activity|alanine-ketomalonate (mesoxalate) transaminase activity|alanine-oxomalonate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047308 GO:0047307 biolink:MolecularActivity diaminobutyrate-pyruvate transaminase activity Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde. EC:2.6.1.46|KEGG_REACTION:R02293|MetaCyc:2.6.1.46-RXN|RHEA:12380 go.json L-2,4-diaminobutanoate:pyruvate aminotransferase activity|L-diaminobutyric acid transaminase activity|diaminobutyrate--pyruvate aminotransferase activity|diaminobutyrate-pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047307 GO:0106173 biolink:CellularComponent COPII-coated vesicle lumen The volume enclosed by the membrane of a COPII-coated endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0106173 GO:0106172 biolink:CellularComponent COPI-coated vesicle lumen The volume enclosed by the membrane of a COPI-coated endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0106172 GO:0106177 biolink:MolecularActivity cyclic-GMP-AMP hydrolase activity Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP. RHEA:58808 go.json http://purl.obolibrary.org/obo/GO_0106177 GO:0106176 biolink:CellularComponent clathrin-coated endocytic vesicle lumen The volume enclosed by the membrane of a clathrin-coated endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0106176 GO:0106175 biolink:CellularComponent phagolysosome vesicle membrane The lipid bylayer surrounding a phagolysosome. go.json http://purl.obolibrary.org/obo/GO_0106175 GO:0106174 biolink:CellularComponent phagolysosome vesicle lumen The volume enclosed by the membrane of a phagolysosome. go.json http://purl.obolibrary.org/obo/GO_0106174 GO:0106179 biolink:MolecularActivity obsolete translocase activity acting on inorganic cations and their chelates OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates. EC:7.2.-.- go.json True http://purl.obolibrary.org/obo/GO_0106179 GO:0106178 biolink:MolecularActivity obsolete translocase activity OBSOLETE. Catalysis the movement of ions or molecules across membranes or their separation within membranes. EC:7.-.-.- go.json True http://purl.obolibrary.org/obo/GO_0106178 GO:0047317 biolink:MolecularActivity N6-acetyl-beta-lysine transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate. EC:2.6.1.65|MetaCyc:2.6.1.65-RXN|RHEA:16889 go.json 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity|N(6)-acetyl-beta-lysine aminotransferase activity|N6-acetyl-beta-lysine aminotransferase activity|epsilon-acetyl-beta-lysine aminotransferase activity http://purl.obolibrary.org/obo/GO_0047317 GO:0047316 biolink:MolecularActivity glutamine-phenylpyruvate transaminase activity Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine. EC:2.6.1.64|KEGG_REACTION:R01375|MetaCyc:2.6.1.64-RXN|RHEA:17593 go.json L-glutamine:phenylpyruvate aminotransferase activity|glutamine transaminase K activity|glutamine--phenylpyruvate aminotransferase activity|glutamine-phenylpyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047316 GO:0047315 biolink:MolecularActivity kynurenine-glyoxylate transaminase activity Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. EC:2.6.1.63|KEGG_REACTION:R01957|MetaCyc:2.6.1.63-RXN|RHEA:19249 go.json L-kynurenine:glyoxylate aminotransferase (cyclizing)|kynurenine--glyoxylate aminotransferase activity|kynurenine-glyoxylate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047315 GO:0047314 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047314 GO:0047313 biolink:MolecularActivity aromatic-amino-acid-glyoxylate transaminase activity Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid. EC:2.6.1.60|MetaCyc:2.6.1.60-RXN|RHEA:10900 go.json aromatic-amino-acid--glyoxylate aminotransferase activity|aromatic-amino-acid-glyoxylate aminotransferase activity|aromatic-amino-acid:glyoxylate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047313 GO:0047312 biolink:MolecularActivity L-phenylalanine:pyruvate aminotransferase activity Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine. EC:2.6.1.58|KEGG_REACTION:R00692|MetaCyc:2.6.1.58-RXN|RHEA:13053|Reactome:R-HSA-893593 go.json L-histidine:pyruvate aminotransferase activity|L-phenylalanine(L-histidine):pyruvate aminotransferase activity|L-phenylalanine:pyruvate transaminase activity|histidine aminotransferase activity|histidine:pyruvate aminotransferase activity|phenylalanine (histidine) aminotransferase activity|phenylalanine(histidine) aminotransferase activity|phenylalanine(histidine) transaminase activity|phenylalanine(histidine):pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047312 GO:0047311 biolink:MolecularActivity 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine. EC:2.6.1.56|KEGG_REACTION:R03502|MetaCyc:2.6.1.56-RXN|RHEA:15497 go.json 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity|1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity|L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity|guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047311 GO:0047310 biolink:MolecularActivity glutamine-scyllo-inositol transaminase activity Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate. EC:2.6.1.50|KEGG_REACTION:R02781|MetaCyc:2.6.1.50-RXN|RHEA:22920 go.json L-glutamine-keto-scyllo-inositol aminotransferase activity|L-glutamine-scyllo-inosose transaminase activity|L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity|glutamine scyllo-inosose aminotransferase activity|glutamine--scyllo-inosose aminotransferase activity|glutamine--scyllo-inosose transaminase activity|glutamine-scyllo-inosose aminotransferase activity|glutamine-scyllo-inosose transaminase activity http://purl.obolibrary.org/obo/GO_0047310 GO:0047319 biolink:MolecularActivity aspartate-phenylpyruvate transaminase activity Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate. EC:2.6.1.70|KEGG_REACTION:R00695|MetaCyc:2.6.1.70-RXN|RHEA:14097 go.json L-aspartate:phenylpyruvate aminotransferase activity|aspartate--phenylpyruvate aminotransferase activity|aspartate-phenylpyruvate aminotransferase activity http://purl.obolibrary.org/obo/GO_0047319 GO:0047318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047318 GO:0106180 biolink:MolecularActivity obsolete translocase activty of hydrons OBSOLETE. Catalysis of the translocation of hydrons (hydron being the general name for H+ in its natural abundance). EC:7.1.-.- go.json True http://purl.obolibrary.org/obo/GO_0106180 GO:0106184 biolink:MolecularActivity obsolete translocation activity acting on other compounds OBSOLETE. Catalysis of the translocation of other compounds not included in EC:7.1 through EC:7.5 . EC:7.6.-.- go.json True http://purl.obolibrary.org/obo/GO_0106184 GO:0106183 biolink:MolecularActivity obsolete translocase activity acting on carbohydrates and their derivatives. OBSOLETE. Catalysis of the translocation of carbohydrates and their derivatives. EC:7.5.-.- go.json True http://purl.obolibrary.org/obo/GO_0106183 GO:0106182 biolink:MolecularActivity obsolete translocase activity acting on amino acids and peptides. OBSOLETE. Catalysis of the translocation of amino acids and peptides. EC:7.4.-.- go.json True http://purl.obolibrary.org/obo/GO_0106182 GO:0106181 biolink:MolecularActivity obsolete translocase activity acting on inorganic anions OBSOLETE. Catalysis of the translocation of inorganic anions. EC:7.3.-.- go.json True http://purl.obolibrary.org/obo/GO_0106181 GO:0106188 biolink:MolecularActivity obsolete translocase activity acting on hydrons linked the hydrolysis of a nucleoside triphosphate OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a nucleoside triphosphate. EC:7.1.2.- go.json True http://purl.obolibrary.org/obo/GO_0106188 GO:0047320 biolink:MolecularActivity D-4-hydroxyphenylglycine transaminase activity Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate. EC:2.6.1.72|KEGG_REACTION:R04234|MetaCyc:2.6.1.72-RXN|RHEA:15589 go.json D-4-hydroxyphenylglycine aminotransferase activity|D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity|D-hydroxyphenylglycine aminotransferase activity http://purl.obolibrary.org/obo/GO_0047320 GO:0106187 biolink:MolecularActivity obsolete translocase activity acting on hydrons linked to oxidoreductase reactions OBSOLETE. Catalysis of the translocation of hydrons linked to an oxidoreduction reaction. EC:7.1.1.- go.json True http://purl.obolibrary.org/obo/GO_0106187 GO:0106186 biolink:CellularComponent cytoplasmic side of plasma membrane, cell tip The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. go.json http://purl.obolibrary.org/obo/GO_0106186 GO:0106185 biolink:BiologicalProcess obsolete histone H3-K37 methylation OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone. go.json histone H3 K37 methylation|histone H3K37me|histone lysine H3 K37 methylation True http://purl.obolibrary.org/obo/GO_0106185 GO:0106189 biolink:MolecularActivity obsolete translocase activity acting on hydrons linked to the hydrolysis of a diphosphate OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a diphosphate. EC:7.1.3.- go.json True http://purl.obolibrary.org/obo/GO_0106189 GO:0047328 biolink:MolecularActivity acyl-phosphate-hexose phosphotransferase activity Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid. EC:2.7.1.61|MetaCyc:2.7.1.61-RXN|RHEA:13077 go.json acyl-phosphate:D-hexose phosphotransferase activity|hexose phosphate:hexose phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047328 GO:0047327 biolink:MolecularActivity glycerol-3-phosphate-glucose phosphotransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol. EC:2.7.1.142|KEGG_REACTION:R00850|MetaCyc:2.7.1.142-RXN|RHEA:21288 go.json sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047327 GO:0047326 biolink:MolecularActivity inositol tetrakisphosphate 5-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. EC:2.7.1.140|MetaCyc:2.7.1.140-RXN|RHEA:12717|Reactome:R-HSA-1855228 go.json 1D-myo-inositol-tetrakisphosphate 5-kinase activity|ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity|inositol 1,3,4,6-tetrakisphosphate 5-kinase activity|inositol-tetrakisphosphate 5-kinase activity http://purl.obolibrary.org/obo/GO_0047326 GO:0047325 biolink:MolecularActivity inositol tetrakisphosphate 1-kinase activity Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. EC:2.7.1.134|MetaCyc:2.7.1.134-RXN|RHEA:12452|Reactome:R-HSA-1855162|Reactome:R-HSA-994137 go.json 1D-myo-inositol-tetrakisphosphate 1-kinase activity|1D-myo-inositol-trisphosphate 5-kinase activity|1D-myo-inositol-trisphosphate 6-kinase activity|ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity|inositol 3,4,5,6-tetrakisphosphate 1-kinase activity|inositol-tetrakisphosphate 1-kinase activity|inositol-trisphosphate 5-kinase activity|inositol-trisphosphate 6-kinase activity http://purl.obolibrary.org/obo/GO_0047325 GO:0047324 biolink:MolecularActivity phosphoenolpyruvate-glycerone phosphotransferase activity Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate. EC:2.7.1.121|KEGG_REACTION:R01012|MetaCyc:2.7.1.121-RXN|RHEA:18381 go.json phosphoenolpyruvate:glycerone phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047324 GO:0047323 biolink:MolecularActivity [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate. EC:2.7.11.4|MetaCyc:2.7.11.4-RXN|RHEA:17301|Reactome:R-HSA-5693148 go.json 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity|ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity|BCK|BCKD kinase activity|BCODH kinase activity|STK2|[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity|branched-chain 2-oxo acid dehydrogenase kinase activity|branched-chain alpha-ketoacid dehydrogenase kinase activity|branched-chain keto acid dehydrogenase kinase activity|branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity http://purl.obolibrary.org/obo/GO_0047323 GO:0047322 biolink:MolecularActivity [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP. EC:2.7.11.31|MetaCyc:2.7.1.109-RXN|RHEA:23172 go.json 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity|3-hydroxy-3-methylglutaryl-CoA reductase kinase activity|AMPK|ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity|HMG-CoA reductase kinase activity|STK29|beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity|hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity|hydroxymethylglutaryl coenzyme A reductase kinase activity|hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity|hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity|hydroxymethylglutaryl-CoA reductase kinase activity|reductase kinase activity http://purl.obolibrary.org/obo/GO_0047322 GO:0047321 biolink:MolecularActivity diphosphate-protein phosphotransferase activity Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein. EC:2.7.99.1|MetaCyc:2.7.99.1-RXN go.json DiPPT|diphosphate:microsomal-membrane-protein O-phosphotransferase activity|pyrophosphate-protein phosphotransferase activity|pyrophosphate:protein phosphotransferase activity|triphosphate-protein phosphotransferase activity|triphosphate:microsomal-membrane-protein phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047321 GO:0047329 biolink:MolecularActivity phosphoramidate-hexose phosphotransferase activity Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3. EC:2.7.1.62|MetaCyc:2.7.1.62-RXN|RHEA:10972 go.json phosphoramidate-hexose transphosphorylase activity|phosphoramidate:hexose 1-phosphotransferase activity|phosphoramidic-hexose transphosphorylase activity http://purl.obolibrary.org/obo/GO_0047329 GO:0106191 biolink:MolecularActivity obsolete translocase activity acting on inogranic cations linked to oxidoreductase reactions OBSOLETE. Catalysis of the translocation of inorganic cations linked to oxidoreductase reactions. EC:7.2.1.- go.json True http://purl.obolibrary.org/obo/GO_0106191 GO:0106190 biolink:MolecularActivity obsolete translocase activity acting on hydrons linked to a decarboxylation reaction OBSOLETE. Catalysis of the translocation of hydrons linked to a decarboxylation reaction. EC:7.1.4.- go.json True http://purl.obolibrary.org/obo/GO_0106190 GO:0106195 biolink:MolecularActivity obsolete translocase activty acting on inorganic anions linked to oxidoreductase reactions OBSOLETE. Catalysis of the translocation of inorganic anions linked to oxidoreductase reactions. EC:7.3.1.- go.json True http://purl.obolibrary.org/obo/GO_0106195 GO:0106194 biolink:MolecularActivity obsolete translocase activity acting on inorganic cations and their chelates linked to a decarboxylation reaction OBSOLETE. Catalysis of the transocation of inorganic cations and their chelates linked to a decarboxylation reaction. EC:7.2.4.- go.json True http://purl.obolibrary.org/obo/GO_0106194 GO:0106193 biolink:MolecularActivity obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a diphosphate OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a diphosphate. EC:7.2.3.- go.json True http://purl.obolibrary.org/obo/GO_0106193 GO:0106192 biolink:MolecularActivity obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate. go.json True http://purl.obolibrary.org/obo/GO_0106192 GO:0106111 biolink:BiologicalProcess regulation of mitotic cohesin ssDNA (lagging strand) loading Any process that modulates the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading. go.json http://purl.obolibrary.org/obo/GO_0106111 GO:0047331 biolink:MolecularActivity diphosphate-glycerol phosphotransferase activity Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H+ + phosphate. EC:2.7.1.79|KEGG_REACTION:R01044|MetaCyc:2.7.1.79-RXN|RHEA:13689 go.json PPi-glycerol phosphotransferase activity|diphosphate:glycerol 1-phosphotransferase activity|pyrophosphate--glycerol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047331 GO:0106110 biolink:BiologicalProcess vomitoxin biosynthetic process The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats. go.json DON biosynthetic process|deoxynivalenol biosynthetic process|vomitoxin anabolism|vomitoxin biosynthesis|vomitoxin formation|vomitoxin synthesis http://purl.obolibrary.org/obo/GO_0106110 GO:0047330 biolink:MolecularActivity polyphosphate-glucose phosphotransferase activity Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate. EC:2.7.1.63|MetaCyc:2.7.1.63-RXN|RHEA:22036 go.json polyphosphate glucokinase activity|polyphosphate-D-(+)-glucose-6-phosphotransferase activity|polyphosphate-glucose 6-phosphotransferase activity|polyphosphate:D-glucose 6-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047330 GO:0106115 biolink:BiologicalProcess negative regulation of mitotic cohesin dsDNA (leading strand) loading Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. go.json http://purl.obolibrary.org/obo/GO_0106115 GO:0106114 biolink:BiologicalProcess regulation of mitotic cohesin dsDNA (leading strand) loading Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. go.json http://purl.obolibrary.org/obo/GO_0106114 GO:0106113 biolink:BiologicalProcess positive regulation of mitotic cohesin ssDNA (lagging strand) loading Any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading. go.json http://purl.obolibrary.org/obo/GO_0106113 GO:0106112 biolink:BiologicalProcess negative regulation of mitotic cohesin ssDNA (lagging strand) loading Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading. go.json http://purl.obolibrary.org/obo/GO_0106112 GO:0047339 biolink:MolecularActivity nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate. EC:2.7.7.28|MetaCyc:2.7.7.28-RXN go.json GDP hexose pyrophosphorylase activity|GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity|GTP:hexose-1-phosphate guanylyltransferase activity|NDP hexose pyrophosphorylase activity|NDP-hexose diphosphorylase activity|NDP-hexose pyrophosphorylase activity|NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity|NTP:hexose-1-phosphate nucleotidyltransferase activity|guanosine diphosphohexose pyrophosphorylase activity|hexose 1-phosphate guanylyltransferase activity|hexose 1-phosphate nucleotidyltransferase activity|hexose nucleotidylating enzyme activity|hexose-1-phosphate guanylyltransferase activity|nucleoside diphosphohexose pyrophosphorylase activity|nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0047339 GO:0106119 biolink:BiologicalProcess negative regulation of sterol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of a sterol biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0106119 GO:0047338 biolink:MolecularActivity UTP:xylose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate. EC:2.7.7.11|MetaCyc:2.7.7.11-RXN|RHEA:18389 go.json UDP-xylose pyrophosphorylase activity|UTP-xylose-1-phosphate uridylyltransferase activity|UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity|uridine diphosphoxylose pyrophosphorylase activity|uridylyltransferase, xylose 1-phosphate|xylose 1-phosphate uridylyltransferase activity|xylose-1-phosphate uridylyltransferase activity http://purl.obolibrary.org/obo/GO_0047338 GO:0106118 biolink:BiologicalProcess regulation of sterol biosynthetic process Any process that modulates the frequency, rate or extent of a sterol biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0106118 GO:0106117 biolink:BiologicalProcess acidocalcisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. go.json acidocalcisome biogenesis|acidocalcisome organisation|acidocalcisome organization and biogenesis|metachromatic granule organization|polyphosphate vacuole organization|volutin granule organization http://purl.obolibrary.org/obo/GO_0106117 GO:0047337 biolink:MolecularActivity dolichyl-diphosphate-polyphosphate phosphotransferase activity Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate. EC:2.7.4.20|MetaCyc:2.7.4.20-RXN|RHEA:19417 go.json dolichyl-diphosphate:polyphosphate phosphotransferase activity|dolichylpyrophosphate:polyphosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047337 GO:0106116 biolink:BiologicalProcess positive regulation of mitotic cohesin dsDNA (leading strand) loading Any process that activates or increases the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. go.json http://purl.obolibrary.org/obo/GO_0106116 GO:0047336 biolink:MolecularActivity 5-methyldeoxycytidine-5'-phosphate kinase activity Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H+. EC:2.7.4.19|KEGG_REACTION:R04235|MetaCyc:2.7.4.19-RXN|RHEA:11396 go.json ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047336 GO:0047335 biolink:MolecularActivity 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate. EC:2.7.4.17|MetaCyc:2.7.4.17-RXN|RHEA:18665 go.json 1,3-diphosphoglycerate-polyphosphate phosphotransferase activity|3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity|diphosphoglycerate-polyphosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047335 GO:0047334 biolink:MolecularActivity diphosphate-fructose-6-phosphate 1-phosphotransferase activity Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate. EC:2.7.1.90|MetaCyc:2.7.1.90-RXN|RHEA:13613 go.json 6-phosphofructokinase (diphosphate) activity|6-phosphofructokinase (pyrophosphate) activity|diphosphate-dependent 6-phosphofructose-1-kinase activity|diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity|inorganic pyrophosphate-dependent phosphofructokinase activity|inorganic pyrophosphate-phosphofructokinase activity|pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity|pyrophosphate-dependent 6-phosphofructose-1-kinase activity|pyrophosphate-dependent phosphofructo-1-kinase activity|pyrophosphate-fructose 6-phosphate phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047334 GO:0047333 biolink:MolecularActivity dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H+. EC:2.7.1.88|KEGG_REACTION:R03395|MetaCyc:2.7.1.88-RXN|RHEA:16281 go.json ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity|ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity|dihydrostreptomycin 6-phosphate kinase (phosphorylating)|dihydrostreptomycin-6-phosphate 3'alpha-kinase activity http://purl.obolibrary.org/obo/GO_0047333 GO:0047332 biolink:MolecularActivity diphosphate-serine phosphotransferase activity Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H+ + phosphate. EC:2.7.1.80|KEGG_REACTION:R00584|MetaCyc:2.7.1.80-RXN|RHEA:23764 go.json diphosphate:L-serine O-phosphotransferase activity|pyrophosphate--serine phosphotransferase activity|pyrophosphate-L-serine phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047332 GO:0106122 biolink:BiologicalProcess negative regulation of cobalamin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process. go.json http://purl.obolibrary.org/obo/GO_0106122 GO:0047342 biolink:MolecularActivity galactose-1-phosphate thymidylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose. EC:2.7.7.32|KEGG_REACTION:R02329|MetaCyc:2.7.7.32-RXN|RHEA:17165 go.json dTDP galactose pyrophosphorylase activity|dTDP-galactose diphosphorylase activity|dTDP-galactose pyrophosphorylase activity|dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity|galactose 1-phosphate thymidylyl transferase activity|thymidine diphosphogalactose pyrophosphorylase activity|thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity http://purl.obolibrary.org/obo/GO_0047342 GO:0106121 biolink:BiologicalProcess positive regulation of cobalamin metabolic process Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process. go.json http://purl.obolibrary.org/obo/GO_0106121 GO:0047341 biolink:MolecularActivity fucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose. EC:2.7.7.30|KEGG_REACTION:R01951|MetaCyc:2.7.7.30-RXN|RHEA:13549|Reactome:R-HSA-6787533 go.json GDP fucose pyrophosphorylase activity|GDP-L-fucose pyrophosphorylase activity|GDP-fucose diphosphorylase activity|GDP-fucose pyrophosphorylase activity|GTP:L-fucose-1-phosphate guanylyltransferase activity|GTP:beta-L-fucose-1-phosphate guanylyltransferase activity|GTP:fucose-1-phosphate guanylyltransferase activity|guanosine diphosphate L-fucose pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0047341 GO:0106120 biolink:BiologicalProcess positive regulation of sterol biosynthetic process Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0106120 GO:0047340 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0047340 GO:0106126 biolink:CellularComponent reservosome membrane The lipid bilayer surrounding a reservosome. go.json http://purl.obolibrary.org/obo/GO_0106126 GO:0106125 biolink:CellularComponent reservosome matrix A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome. go.json http://purl.obolibrary.org/obo/GO_0106125 GO:0106124 biolink:CellularComponent reservosome lumen The volume enclosed by the membranes of a reservosome. go.json http://purl.obolibrary.org/obo/GO_0106124 GO:0106123 biolink:CellularComponent reservosome A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes. go.json http://purl.obolibrary.org/obo/GO_0106123 GO:0047349 biolink:MolecularActivity D-ribitol-5-phosphate cytidylyltransferase activity Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate. EC:2.7.7.40|KEGG_REACTION:R02921|MetaCyc:2.7.7.40-RXN|RHEA:12456 go.json CDP ribitol pyrophosphorylase activity|CDP-ribitol diphosphorylase activity|CDP-ribitol pyrophosphorylase activity|CTP:D-ribitol-5-phosphate cytidylyltransferase activity|cytidine diphosphate ribitol pyrophosphorylase activity|cytidine diphosphoribitol pyrophosphorylase activity|ribitol 5-phosphate cytidylyltransferase activity http://purl.obolibrary.org/obo/GO_0047349 GO:0106129 biolink:BiologicalProcess positive regulation of store-operated calcium entry Any process that activates or increases the frequency, rate or extent of store-operated calcium entry. go.json http://purl.obolibrary.org/obo/GO_0106129 GO:0047348 biolink:MolecularActivity glycerol-3-phosphate cytidylyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate. EC:2.7.7.39|KEGG_REACTION:R00856|MetaCyc:2.7.7.39-RXN|RHEA:13361 go.json CDP-glycerol diphosphorylase activity|CDP-glycerol pyrophosphorylase activity|CTP:glycerol 3-phosphate cytidylyltransferase activity|CTP:glycerol-3-phosphate cytidylyltransferase activity|CTP:sn-glycerol-3-phosphate cytidylyltransferase activity|Gro-PCT|cytidine diphosphate glycerol pyrophosphorylase activity|cytidine diphosphoglycerol pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0047348 GO:0106128 biolink:BiologicalProcess negative regulation of store-operated calcium entry Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium entry. go.json http://purl.obolibrary.org/obo/GO_0106128 GO:0047347 biolink:MolecularActivity aldose-1-phosphate nucleotidyltransferase activity Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose. EC:2.7.7.37|MetaCyc:2.7.7.37-RXN go.json NDP sugar phosphorylase activity|NDP-aldose phosphorylase activity|NDP-sugar phosphorylase activity|NDP:aldose-1-phosphate nucleotidyltransferase activity|NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity|NDPaldose phosphorylase activity|glucose 1-phosphate inosityltransferase activity|nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity|nucleoside diphosphosugar phosphorylase activity|sugar nucleotide phosphorylase activity|sugar phosphate nucleotidyltransferase activity|sugar-1-phosphate nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0047347 GO:0047346 biolink:MolecularActivity aldose-1-phosphate adenylyltransferase activity Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose. EC:2.7.7.36|MetaCyc:2.7.7.36-RXN go.json ADP sugar phosphorylase activity|ADP-aldose phosphorylase activity|ADP-sugar phosphorylase activity|ADP:aldose-1-phosphate adenylyltransferase activity|ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity|ADPaldose phosphorylase activity|adenosine diphosphate glucose:orthophosphate adenylyltransferase activity|adenosine diphosphosugar phosphorylase activity|sugar-1-phosphate adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0047346 GO:0047345 biolink:MolecularActivity ribose-5-phosphate adenylyltransferase activity Catalysis of the reaction: D-ribose 5-phosphate + ADP + H+ = ADP-ribose + phosphate. EC:2.7.7.35|KEGG_REACTION:R01052|MetaCyc:2.7.7.35-RXN|RHEA:14529 go.json ADP ribose phosphorylase activity|ADP-ribose phosphorylase activity|ADP:D-ribose-5-phosphate adenylyltransferase activity|ADP:ribose-5-phosphate adenylyltransferase activity|adenosine diphosphoribose phosphorylase activity http://purl.obolibrary.org/obo/GO_0047345 GO:0047344 biolink:MolecularActivity glucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose. EC:2.7.7.34|KEGG_REACTION:R00954|MetaCyc:2.7.7.34-RXN|RHEA:10708 go.json GDP glucose pyrophosphorylase activity|GDP-glucose diphosphorylase activity|GDP-glucose pyrophosphorylase activity|GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity|GTP:glucose-1-phosphate guanylyltransferase activity|guanosine diphosphoglucose pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0047344 GO:0047343 biolink:MolecularActivity glucose-1-phosphate cytidylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate. EC:2.7.7.33|KEGG_REACTION:R00956|MetaCyc:2.7.7.33-RXN|RHEA:18213 go.json CDP glucose pyrophosphorylase activity|CDP-glucose diphosphorylase activity|CDP-glucose pyrophosphorylase activity|CTP:D-glucose-1-phosphate cytidylyltransferase activity|CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity|CTP:glucose-1-phosphate cytidylyltransferase activity|cytidine diphosphate glucose pyrophosphorylase activity|cytidine diphosphate-D-glucose pyrophosphorylase activity|cytidine diphosphoglucose pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0047343 GO:0047353 biolink:MolecularActivity N-methylphosphoethanolamine cytidylyltransferase activity Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate. EC:2.7.7.57|KEGG_REACTION:R03375|MetaCyc:2.7.7.57-RXN|RHEA:10576 go.json CTP:N-methylethanolamine-phosphate cytidylyltransferase activity|CTP:N-methylphosphoethanolamine cytidylyltransferase activity|CTP:P-MEA cytidylyltransferase activity|monomethylethanolamine phosphate cytidylyltransferase activity http://purl.obolibrary.org/obo/GO_0047353 GO:0047352 biolink:MolecularActivity adenylylsulfate-ammonia adenylyltransferase activity Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate. EC:2.7.7.51|KEGG_REACTION:R01619|MetaCyc:2.7.7.51-RXN|RHEA:19197 go.json APSAT|adenylylsulfate:ammonia adenylyltransferase activity|adenylylsulphate-ammonia adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0047352 GO:0047351 biolink:MolecularActivity GTP guanylyltransferase activity Catalysis of the reaction: 2 GTP + H+ = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H+. EC:2.7.7.45|KEGG_REACTION:R00012|MetaCyc:2.7.7.45-RXN|RHEA:18153 go.json GTP:GTP guanylyltransferase activity|guanosine-triphosphate guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0047351 GO:0106130 biolink:MolecularActivity purine phosphoribosyltransferase activity Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate. Reactome:R-HSA-74215|Reactome:R-HSA-9734274|Reactome:R-HSA-9748951 go.json http://purl.obolibrary.org/obo/GO_0106130 GO:0047350 biolink:MolecularActivity glucuronate-1-phosphate uridylyltransferase activity Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate. EC:2.7.7.44|KEGG_REACTION:R01381|MetaCyc:2.7.7.44-RXN|RHEA:16325 go.json UDP-D-glucuronic acid pyrophosphorylase activity|UDP-glucuronate pyrophosphorylase activity|UDP-glucuronic acid pyrophosphorylase activity|UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity|UTP:glucuronate-1-phosphate uridylyltransferase activity|uridine diphosphoglucuronic pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0047350 GO:0106137 biolink:MolecularActivity IkappaB kinase complex binding Binding to a IkappaB kinase complex. go.json http://purl.obolibrary.org/obo/GO_0106137 GO:0106136 biolink:BiologicalProcess lectin-induced modified bacterial internalization The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json LIMBI http://purl.obolibrary.org/obo/GO_0106136 GO:0106135 biolink:BiologicalProcess negative regulation of cardiac muscle cell contraction Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction. go.json http://purl.obolibrary.org/obo/GO_0106135 GO:0106134 biolink:BiologicalProcess positive regulation of cardiac muscle cell contraction Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction. go.json http://purl.obolibrary.org/obo/GO_0106134 GO:0106139 biolink:CellularComponent symbiont cell surface The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json endosymbiont cell surface http://purl.obolibrary.org/obo/GO_0106139 GO:0047359 biolink:MolecularActivity 1-alkenyl-2-acylglycerol choline phosphotransferase activity Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP. EC:2.7.8.22|MetaCyc:2.7.8.22-RXN|RHEA:36227 go.json CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity|CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity http://purl.obolibrary.org/obo/GO_0047359 GO:0047358 biolink:MolecularActivity UDP-glucose-glycoprotein glucose phosphotransferase activity Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP. EC:2.7.8.19|MetaCyc:2.7.8.19-RXN|RHEA:20181 go.json Glc-phosphotransferase activity|GlcPTase activity|UDP-glucose:glycoprotein glucose-1-phosphotransferase activity|UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity|UDPglucose-glycoprotein glucose phosphotransferase activity|UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity|uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047358 GO:0106138 biolink:MolecularActivity Sec61 translocon complex binding Binding to a Sec61 translocon complex. go.json http://purl.obolibrary.org/obo/GO_0106138 GO:0047357 biolink:MolecularActivity UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP. EC:2.7.8.18|KEGG_REACTION:R00504|MetaCyc:2.7.8.18-RXN|RHEA:22440 go.json UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity|UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity|UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity|galactose-1-phosphotransferase activity|galactosyl phosphotransferase activity|uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047357 GO:0047356 biolink:MolecularActivity CDP-ribitol ribitolphosphotransferase activity Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP. EC:2.7.8.14|MetaCyc:RXN-18380|RHEA:13353 go.json CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity|CDPribitol ribitolphosphotransferase activity|poly(ribitol phosphate) synthetase activity|polyribitol phosphate polymerase activity|polyribitol phosphate synthetase activity|teichoate synthase activity|teichoate synthetase activity|teichoic-acid synthase activity http://purl.obolibrary.org/obo/GO_0047356 GO:0047355 biolink:MolecularActivity CDP-glycerol glycerophosphotransferase activity Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP. EC:2.7.8.12|MetaCyc:TEICHOICSYN4-RXN|RHEA:13565 go.json CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity|CDPglycerol glycerophosphotransferase activity|CGPTase activity|cytidine diphosphoglycerol glycerophosphotransferase activity|glycerophosphate synthetase activity|poly(glycerol phosphate) polymerase activity|teichoic acid glycerol transferase activity|teichoic-acid synthase activity http://purl.obolibrary.org/obo/GO_0047355 GO:0047354 biolink:MolecularActivity sphingosine cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + sphingosine = CMP + H+ + sphingosyl-phosphocholine. EC:2.7.8.10|KEGG_REACTION:R01929|MetaCyc:2.7.8.10-RXN|RHEA:21224 go.json CDP-choline-sphingosine cholinephosphotransferase activity|CDP-choline:sphingosine cholinephosphotransferase activity|cytidine diphosphocholine-sphingosine cholinephosphotransferase activity|phosphorylcholine-sphingosine transferase activity|sphingosine choline phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047354 GO:0072319 biolink:BiologicalProcess vesicle uncoating A protein depolymerization process that results in the disassembly of vesicle coat proteins. go.json vesicle coat disassembly http://purl.obolibrary.org/obo/GO_0072319 GO:0072318 biolink:BiologicalProcess clathrin coat disassembly The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system. go.json clathrin-coat disassembly|clathrin-coat uncoating|clathrin-coated vesicle uncoating http://purl.obolibrary.org/obo/GO_0072318 GO:0072317 biolink:MolecularActivity obsolete glucan endo-1,3-beta-D-glucosidase activity involved in ascospore release from ascus OBSOLETE. Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans that contributes to the release of ascospores from the ascus. go.json True http://purl.obolibrary.org/obo/GO_0072317 GO:0072316 biolink:BiologicalProcess alpha-glucan catabolic process involved in ascospore release from ascus The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus. go.json alpha-glucan breakdown involved in ascospore release from ascus|alpha-glucan catabolism involved in ascospore release from ascus|alpha-glucan degradation involved in ascospore release from ascus http://purl.obolibrary.org/obo/GO_0072316 GO:0072315 biolink:BiologicalProcess metanephric glomerular epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0072315 GO:0072314 biolink:BiologicalProcess glomerular epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0072314 GO:0106140 biolink:MolecularActivity P-TEFb complex binding Binding to a P-TEFb complex. go.json http://purl.obolibrary.org/obo/GO_0106140 GO:0072313 biolink:BiologicalProcess metanephric glomerular epithelial cell development The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0072313 GO:0072312 biolink:BiologicalProcess metanephric glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0072312 GO:0072311 biolink:BiologicalProcess glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0072311 GO:0072310 biolink:BiologicalProcess glomerular epithelial cell development The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0072310 GO:0047364 biolink:MolecularActivity desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H+. EC:2.8.2.24|KEGG_REACTION:R03214|MetaCyc:RXN-4606|RHEA:20281 go.json 3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity|3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity|PAPS-desulfoglucosinolate sulfotransferase activity|desulphoglucosinolate sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047364 GO:0106144 biolink:MolecularActivity fraxetin 5-hydroxylase activity Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20. EC:1.14.14.164|RHEA:57844 go.json http://purl.obolibrary.org/obo/GO_0106144 GO:0106143 biolink:CellularComponent tRNA (m7G46) methyltransferase complex A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat). go.json Trm8-Trm82 complex|tRNA (m7G46) methyltransferase|tRNA m7G methylation complex http://purl.obolibrary.org/obo/GO_0106143 GO:0047363 biolink:MolecularActivity triglucosylalkylacylglycerol sulfotransferase activity Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate. EC:2.8.2.19|MetaCyc:2.8.2.19-RXN|RHEA:13273 go.json 3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity|triglucosylalkylacylglycerol sulphotransferase activity|triglucosylmonoalkylmonoacyl sulfotransferase activity http://purl.obolibrary.org/obo/GO_0047363 GO:0106142 biolink:MolecularActivity rRNA (adenine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA. EC:2.1.1.287|RHEA:43792 go.json 25S rRNA (adenine(645)-N(1))-methyltransferase|25S rRNA m(1)A(645) methyltransferase http://purl.obolibrary.org/obo/GO_0106142 GO:0047362 biolink:MolecularActivity thiosulfate-dithiol sulfurtransferase activity Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite. EC:2.8.1.5|MetaCyc:2.8.1.5-RXN|RHEA:15121 go.json TSR|thiosulfate reductase activity|thiosulfate:dithioerythritol sulfurtransferase activity|thiosulphate-dithiol sulphurtransferase activity http://purl.obolibrary.org/obo/GO_0047362 GO:0106141 biolink:MolecularActivity flavin prenyltransferase activity Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate. EC:2.5.1.129|RHEA:37743 go.json http://purl.obolibrary.org/obo/GO_0106141 GO:0047361 biolink:MolecularActivity phosphomannan mannosephosphotransferase activity Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP. EC:2.7.8.9|MetaCyc:2.7.8.9-RXN go.json GDP-mannose:phosphomannan mannose phosphotransferase activity http://purl.obolibrary.org/obo/GO_0047361 GO:0047360 biolink:MolecularActivity undecaprenyl-phosphate galactose phosphotransferase activity Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP. EC:2.7.8.6|KEGG_REACTION:R01535|MetaCyc:2.7.8.6-RXN|RHEA:11652 go.json UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity|poly(isoprenol)-phosphate galactose phosphotransferase activity|poly(isoprenol)-phosphate galactosephosphotransferase activity|poly(isoprenyl)phosphate galactosephosphatetransferase activity|undecaprenyl phosphate galactosyl-1-phosphate transferase activity http://purl.obolibrary.org/obo/GO_0047360 GO:0106148 biolink:BiologicalProcess 4-hydroxyindole-3- carbonyl nitrile biosynthesis The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside. go.json http://purl.obolibrary.org/obo/GO_0106148 GO:0106147 biolink:BiologicalProcess fraxetin biosynthesis The chemical reactions and pathways resulting in the formation of fraxetin. go.json http://purl.obolibrary.org/obo/GO_0106147 GO:0106146 biolink:BiologicalProcess sideretin biosynthesis The chemical reactions and pathways resulting in the formation of sideretin. go.json http://purl.obolibrary.org/obo/GO_0106146 GO:0106145 biolink:MolecularActivity scopoletin 8-hydroxylase activity Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2). EC:1.14.11.60|RHEA:57848 go.json http://purl.obolibrary.org/obo/GO_0106145 GO:0047369 biolink:MolecularActivity succinate-hydroxymethylglutarate CoA-transferase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. EC:2.8.3.13|MetaCyc:2.8.3.13-RXN|RHEA:12284 go.json dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity|hydroxymethylglutarate coenzyme A-transferase activity|succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity http://purl.obolibrary.org/obo/GO_0047369 GO:0106149 biolink:MolecularActivity indole-3-carbonyl nitrile 4-hydroxylase activity Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20. EC:1.14.14.165|RHEA:57864 go.json http://purl.obolibrary.org/obo/GO_0106149 GO:0047368 biolink:MolecularActivity UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate. EC:2.8.2.7|KEGG_REACTION:R04476|MetaCyc:2.8.2.7-RXN|RHEA:14337 go.json 3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity|UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity|uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity|uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity http://purl.obolibrary.org/obo/GO_0047368 GO:0047367 biolink:MolecularActivity quercetin-3,3'-bissulfate 7-sulfotransferase activity Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate. EC:2.8.2.28|MetaCyc:2.8.2.28-RXN|RHEA:21860 go.json 3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity|7-sulfotransferase activity|PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity|flavonol 7-sulfotransferase activity|quercetin-3,3'-bissulphate 7-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047367 GO:0047366 biolink:MolecularActivity quercetin-3-sulfate 4'-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,4'-disulfate. EC:2.8.2.27|KEGG_REACTION:R02633|MetaCyc:2.8.2.27-RXN|RHEA:17205 go.json 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity|PAPS:flavonol 3-sulfate 4'-sulfotransferase activity|flavonol 4'-sulfotransferase activity|quercetin-3-sulphate 4'-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047366 GO:0047365 biolink:MolecularActivity quercetin-3-sulfate 3'-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,3'-disulfate. EC:2.8.2.26|KEGG_REACTION:R02632|MetaCyc:2.8.2.26-RXN|RHEA:22504 go.json 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity|3'-sulfotransferase activity|PAPS:flavonol 3-sulfate 3'-sulfotransferase activity|flavonol 3'-sulfotransferase activity|quercetin-3-sulphate 3'-sulphotransferase activity http://purl.obolibrary.org/obo/GO_0047365 GO:0072309 biolink:BiologicalProcess mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. go.json http://purl.obolibrary.org/obo/GO_0072309 GO:0072308 biolink:BiologicalProcess negative regulation of metanephric nephron tubule epithelial cell differentiation Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0072308 GO:0072307 biolink:BiologicalProcess regulation of metanephric nephron tubule epithelial cell differentiation Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0072307 GO:0072306 biolink:BiologicalProcess positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. go.json positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072306 GO:0072305 biolink:BiologicalProcess negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. go.json negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072305 GO:0072304 biolink:BiologicalProcess regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. go.json regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis http://purl.obolibrary.org/obo/GO_0072304 GO:0072303 biolink:BiologicalProcess positive regulation of glomerular metanephric mesangial cell proliferation Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0072303 GO:0072302 biolink:BiologicalProcess negative regulation of metanephric glomerular mesangial cell proliferation Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0072302 GO:0106151 biolink:MolecularActivity CNBH domain intrinsic ligand binding Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide. go.json http://purl.obolibrary.org/obo/GO_0106151 GO:0072301 biolink:BiologicalProcess regulation of metanephric glomerular mesangial cell proliferation Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0072301 GO:0106150 biolink:BiologicalProcess zearalenone biosynthetic process The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals. go.json http://purl.obolibrary.org/obo/GO_0106150 GO:0072300 biolink:BiologicalProcess positive regulation of metanephric glomerulus development Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. go.json http://purl.obolibrary.org/obo/GO_0072300 GO:0052049 biolink:BiologicalProcess obsolete interaction with host via protein secreted by type III secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052049 GO:0052048 biolink:BiologicalProcess obsolete interaction with host via secreted substance OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json interaction with host via secreted substance during symbiotic interaction|interaction with host via secreted substance involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052048 GO:0052043 biolink:BiologicalProcess obsolete modification by symbiont of host cellular component OBSOLETE. The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052043 GO:0052042 biolink:BiologicalProcess symbiont-mediated activation of host programmed cell death A process in which a symbiont gene product activates host programmed cell death, leading to an increase in the frequency, rate or extent of programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of host programmed cell death|activation by organism of non-apoptotic programmed cell death in other organism|activation by organism of programmed cell death in other organism during symbiotic interaction|activation by symbiont of host programmed cell death|enhancement of host programmed cell death|enhancement of host programmed cell death by organism|induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction|induction by organism of programmed cell death in other organism during symbiotic interaction|induction by organism of programmed cell death in other organism involved in symbiotic interaction|induction by symbiont of host programmed cell death|induction of non-apoptotic programmed cell death by other organism|pathogenesis|positive regulation by symbiont of host non-apoptotic programmed cell death|positive regulation by symbiont of host programmed cell death|stimulation by symbiont of host programmed cell death|upregulation by symbiont of host programmed cell death http://purl.obolibrary.org/obo/GO_0052042 GO:0052041 biolink:BiologicalProcess symbiont-mediated suppression of host programmed cell death A process in which a symbiont gene product inhibits host programmed cell death, leading to a decrease in the frequency, rate or extent of programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host programmed cell death|down-regulation by symbiont of host programmed cell death|downregulation by symbiont of host programmed cell death|inhibition by symbiont of host programmed cell death|inhibition of host programmed cell death|negative regulation by symbiont of host programmed cell death|suppression by symbiont of host PCD|suppression by symbiont of host programmed cell death http://purl.obolibrary.org/obo/GO_0052041 GO:0052040 biolink:BiologicalProcess symbiont-mediated perturbation of host programmed cell death A process in which a symbiont gene product affects host programmed cell death, leading to a change in the frequency, rate or extent of host programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host non-apoptotic programmed cell death|modulation by symbiont of host programmed cell death|modulation of host PCD http://purl.obolibrary.org/obo/GO_0052040 GO:0052047 biolink:BiologicalProcess obsolete symbiotic process mediated by secreted substance OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction. go.json interaction with other organism via secreted substance during symbiotic interaction|interaction with other organism via secreted substance involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052047 GO:0052046 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via secreted substance OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification of host morphology or physiology via effector molecule|modification of host morphology or physiology via ellicitor True http://purl.obolibrary.org/obo/GO_0052046 GO:0052045 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052045 GO:0052044 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052044 GO:0052059 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052059 GO:0052050 biolink:BiologicalProcess obsolete interaction with host via substance secreted by type IV secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052050 GO:0052054 biolink:BiologicalProcess obsolete negative regulation by symbiont of host peptidase activity OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host protease activity|down-regulation by symbiont of host protease activity|downregulation by symbiont of host protease activity|inhibition by symbiont of host protease activity|inhibition of host protease activity|negative regulation by symbiont of host protease activity True http://purl.obolibrary.org/obo/GO_0052054 GO:0052053 biolink:BiologicalProcess negative regulation by symbiont of host catalytic activity Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host enzyme activity|down-regulation by symbiont of host enzyme activity|downregulation by symbiont of host enzyme activity|inhibition by symbiont of host enzyme activity|inhibition of host enzyme activity|negative regulation by symbiont of host enzyme activity|negative regulation by symbiont of host molecular function http://purl.obolibrary.org/obo/GO_0052053 GO:0052052 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by type II secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052052 GO:0052051 biolink:BiologicalProcess obsolete interaction with host via protein secreted by type II secretion system OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052051 GO:0052058 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052058 GO:0052057 biolink:BiologicalProcess obsolete modification by symbiont of host morphology or physiology via protein secreted by type III secretion system OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052057 GO:0052056 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052056 GO:0052055 biolink:BiologicalProcess modulation by symbiont of host molecular function The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modification by symbiont of host molecular function|modification by symbiont of host protein function http://purl.obolibrary.org/obo/GO_0052055 GO:0003098 biolink:BiologicalProcess tubuloglomerular feedback The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus. Wikipedia:Tubuloglomerular_feedback go.json http://purl.obolibrary.org/obo/GO_0003098 GO:0003097 biolink:BiologicalProcess renal water transport The directed movement of water (H2O) by the renal system. go.json http://purl.obolibrary.org/obo/GO_0003097 GO:0003099 biolink:BiologicalProcess positive regulation of the force of heart contraction by chemical signal Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. go.json positive regulation of the force of heart muscle contraction by chemical signal http://purl.obolibrary.org/obo/GO_0003099 GO:0003094 biolink:BiologicalProcess glomerular filtration The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein. go.json http://purl.obolibrary.org/obo/GO_0003094 GO:0003093 biolink:BiologicalProcess regulation of glomerular filtration Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. go.json http://purl.obolibrary.org/obo/GO_0003093 GO:0003096 biolink:BiologicalProcess renal sodium ion transport The directed movement of sodium ions (Na+) by the renal system. go.json http://purl.obolibrary.org/obo/GO_0003096 GO:0003095 biolink:BiologicalProcess pressure natriuresis The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis). go.json http://purl.obolibrary.org/obo/GO_0003095 GO:0052061 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052061 GO:0052060 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052060 GO:0052065 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052065 GO:0052064 biolink:BiologicalProcess induction by symbiont of defense-related host reactive oxygen species production The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of defense-related host ROI production|activation by symbiont of defense-related host ROS production|activation by symbiont of defense-related host metabolic burst|activation by symbiont of defense-related host oxidative burst|activation by symbiont of defense-related host reactive oxidative species production|activation by symbiont of defense-related host reactive oxygen intermediate production|activation by symbiont of defense-related host reactive oxygen species production|activation by symbiont of defense-related host respiratory burst|induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|induction by symbiont of defense-related host AOS production|induction by symbiont of defense-related host active oxygen species production|induction by symbiont of defense-related host metabolic burst|induction by symbiont of defense-related host oxidative burst|induction by symbiont of defense-related host reactive oxidative species production|induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|positive regulation by symbiont of defense-related host reactive oxygen species production|stimulation by symbiont of defense-related host reactive oxygen species production|up regulation by symbiont of defense-related host reactive oxygen species production|up-regulation by symbiont of defense-related host reactive oxygen species production|upregulation by symbiont of defense-related host reactive oxygen species production http://purl.obolibrary.org/obo/GO_0052064 GO:0052063 biolink:BiologicalProcess obsolete induction by symbiont of defense-related host nitric oxide production OBSOLETE. The activation by a symbiont of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related host NO production|activation by organism of defense-related host nitric oxide production|activation by symbiont of defense-related host nitric oxide production|induction by organism of defense-related host NO production|induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction|positive regulation by organism of defense-related host NO production|positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction|positive regulation by symbiont of defense-related host nitric oxide production|stimulation by symbiont of defense-related host nitric oxide production|up regulation by symbiont of defense-related host nitric oxide production|up-regulation by symbiont of defense-related host nitric oxide production|upregulation by symbiont of defense-related host nitric oxide production True http://purl.obolibrary.org/obo/GO_0052063 GO:0052062 biolink:BiologicalProcess induction by symbiont of host phytoalexin production The activation by a symbiont of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of host phytoalexin production|induction by organism of phytoalexin production in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052062 GO:0052069 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052069 GO:0052068 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052068 GO:0052067 biolink:BiologicalProcess disruption of host phagocytosis A process in which in a symbiont interferes with or inhibits host phagocytosis by targeting phagocytic signaling or the cellular phagocytic machinery. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json antiphagocytosis|inhibition by symbiont of entry into host cell via phagocytosis|modulation by organism of entry into host via host phagocytosis|modulation by symbiont of entry into host via phagocytosis|phagocytosis avoidence http://purl.obolibrary.org/obo/GO_0052067 GO:0052066 biolink:BiologicalProcess obsolete entry of symbiont into host cell by promotion of host phagocytosis OBSOLETE. The invasion by a symbiont of a host organism cell by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction|entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction|entry of organism into host cell by promotion of host phagocytosis|penetration of organism into host cell by promotion of host phagocytosis|penetration of symbiont into host cell by promotion of host phagocytosis True http://purl.obolibrary.org/obo/GO_0052066 GO:0052072 biolink:BiologicalProcess obsolete induction by symbiont of defense-related host salicylic acid-mediated signal transduction pathway OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related host SA-mediated signal transduction pathway|activation by organism of defense-related host salicylic acid-mediated signal transduction pathway|activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|induction by organism of defense-related host SA-mediated signal transduction pathway|induction by organism of defense-related host salicylic acid-mediated signal transduction pathway|positive regulation by organism of defense-related host SA-mediated signal transduction pathway|positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|upregulation by organism of defense-related host SA-mediated signal transduction pathway|upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway|upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052072 GO:0052071 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052071 GO:0052070 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052070 GO:0052076 biolink:BiologicalProcess obsolete induction by symbiont of host ethylene-mediated defense response OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host ethylene-mediated defense response|positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction|positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway|positive regulation by symbiont of host ethylene-mediated defense response|stimulation by symbiont of host ethylene-mediated defense response|up regulation by symbiont of host ethylene-mediated defense response|up-regulation by symbiont of host ethylene-mediated defense response|upregulation by symbiont of host ethylene-mediated defense response True http://purl.obolibrary.org/obo/GO_0052076 GO:0052075 biolink:BiologicalProcess induction by symbiont of host jasmonic acid-mediated defense response Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host jasmonic acid-mediated defense response|induction by organism of host JA-mediated defense response|induction by organism of host jasmonic acid-mediated defense response|positive regulation by organism of host JA-mediated defense response|positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction|positive regulation by symbiont of host jasmonic acid-mediated defense response|stimulation by symbiont of host jasmonic acid-mediated defense response|up regulation by symbiont of host jasmonic acid-mediated defense response|up-regulation by symbiont of host jasmonic acid-mediated defense response|upregulation by symbiont of host jasmonic acid-mediated defense response http://purl.obolibrary.org/obo/GO_0052075 GO:0052074 biolink:BiologicalProcess positive regulation by symbiont of host salicylic acid-mediated defense response Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host salicylic acid-mediated defense response|induction by organism of host SA-mediated defense response|induction by organism of host salicylic acid-mediated defense response|positive regulation by organism of host SA-mediated defense response|positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction|stimulation by symbiont of host salicylic acid-mediated defense response|up regulation by symbiont of host salicylic acid-mediated defense response|up-regulation by symbiont of host salicylic acid-mediated defense response|upregulation by symbiont of host salicylic acid-mediated defense response http://purl.obolibrary.org/obo/GO_0052074 GO:0052073 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052073 GO:0052079 biolink:BiologicalProcess obsolete induction by symbiont of defense-related host MAP kinase-mediated signal transduction pathway OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related host MAP kinase-mediated signal transduction pathway|activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|induction by organism of defense-related host MAP kinase-mediated signal transduction pathway|positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction|positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway|positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway|positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway|upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052079 GO:0052078 biolink:BiologicalProcess symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway A process in which a virus interferes with, inhibits or disrupts a PAMP signaling pathway in its host organism, initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of defense-related host MAP kinase-mediated signal transduction pathway|disruption of host PAMP receptor signaling pathway|disruption of host pathogen-associated molecular pattern receptor signaling pathway|inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway|suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|suppression of host pathogen-associated molecular pattern receptor signaling pathway http://purl.obolibrary.org/obo/GO_0052078 GO:0052077 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052077 GO:0003079 biolink:BiologicalProcess obsolete positive regulation of natriuresis OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis. go.json positive regulation of natriuresis True http://purl.obolibrary.org/obo/GO_0003079 GO:0003076 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003076 GO:0003075 biolink:BiologicalProcess renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system. go.json renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system http://purl.obolibrary.org/obo/GO_0003075 GO:0003078 biolink:BiologicalProcess obsolete regulation of natriuresis OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion. go.json regulation of natriuresis True http://purl.obolibrary.org/obo/GO_0003078 GO:0003077 biolink:BiologicalProcess obsolete negative regulation of diuresis OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion. go.json negative regulation of diuresis True http://purl.obolibrary.org/obo/GO_0003077 GO:0003072 biolink:BiologicalProcess renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature. go.json regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence|renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence http://purl.obolibrary.org/obo/GO_0003072 GO:0003071 biolink:BiologicalProcess renal system process involved in regulation of systemic arterial blood pressure Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. go.json renal control of blood pressure|renal regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0003071 GO:0003074 biolink:BiologicalProcess obsolete regulation of diuresis OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion. go.json regulation of diuresis True http://purl.obolibrary.org/obo/GO_0003074 GO:0003073 biolink:BiologicalProcess regulation of systemic arterial blood pressure The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. go.json http://purl.obolibrary.org/obo/GO_0003073 GO:0003081 biolink:BiologicalProcess regulation of systemic arterial blood pressure by renin-angiotensin The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. go.json blood pressure regulation by renin-angiotensin http://purl.obolibrary.org/obo/GO_0003081 GO:0003080 biolink:BiologicalProcess obsolete negative regulation of natriuresis OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion. go.json negative regulation of natriuresis True http://purl.obolibrary.org/obo/GO_0003080 GO:0052083 biolink:BiologicalProcess suppression by symbiont of host cell-mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host cell-mediated immune response|down-regulation by symbiont of host cell-mediated immune response|downregulation by symbiont of host cell-mediated immune response|inhibition by symbiont of host cell-mediated immune response|negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction|negative regulation by organism of host cell-based immune response http://purl.obolibrary.org/obo/GO_0052083 GO:0052082 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052082 GO:0052081 biolink:BiologicalProcess perturbation of defense-related host salicylic acid-mediated signal transduction pathway A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|modulation of defense-related host SA-mediated signal transduction pathway by organism http://purl.obolibrary.org/obo/GO_0052081 GO:0052080 biolink:BiologicalProcess perturbation of host MAPK signal transduction pathway A process in which a symbiont alters or subverts a MAP kinase-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|modulation by symbiont of host innate immune response MAPK kinase signaling|modulation of defense-related host MAPK-mediated signal transduction pathway by organism|modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism|pertubation of host innate immune response MAPK kinase signaling|perturbation by symbiont of host MAP kinase signal transduction pathway|perturbation of host MAP signal transduction pathway|perturbation of host MAPK kinase signaling pathway http://purl.obolibrary.org/obo/GO_0052080 GO:0052087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052087 GO:0052086 biolink:BiologicalProcess suppression of host B-cell mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host B-cell mediated immune response|down-regulation by symbiont of host B-cell mediated immune response|downregulation by symbiont of host B-cell mediated immune response|inhibition by symbiont of host B-cell mediated immune response|negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction|suppression by symbiont of host B-cell mediated immune response http://purl.obolibrary.org/obo/GO_0052086 GO:0052085 biolink:BiologicalProcess suppression of host T-cell mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host T-cell mediated immune response|down-regulation by symbiont of host T-cell mediated immune response|downregulation by symbiont of host T-cell mediated immune response|inhibition by symbiont of host T-cell mediated immune response|negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction|negative regulation by symbiont of host T-cell mediated immune response|suppression by symbiont of host T-cell mediated immune response http://purl.obolibrary.org/obo/GO_0052085 GO:0052084 biolink:BiologicalProcess modulation by symbiont of host ethylene-mediated defense response Any process in which a symbiont modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction|modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway http://purl.obolibrary.org/obo/GO_0052084 GO:0052089 biolink:BiologicalProcess modulation by symbiont of host salicylic acid-mediated defense response Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of host SA-mediated defense response|modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052089 GO:0052088 biolink:BiologicalProcess symbiont defense to host-produced jasmonic acid Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related host SA-mediated signal transduction pathway|activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway|activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|down regulation by symbiont of host jasmonic acid-mediated defense response|down-regulation by symbiont of host jasmonic acid-mediated defense response|downregulation by symbiont of host jasmonic acid-mediated defense response|induction by organism of defense-related host SA-mediated signal transduction pathway|induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway|induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|inhibition by symbiont of host jasmonic acid-mediated defense response|modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|modulation by organism of host JA-mediated defense response|modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction|modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction|negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|negative regulation by symbiont of host jasmonic acid-mediated defense response|positive regulation by organism of defense-related host SA-mediated signal transduction pathway|positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|suppression by organism of host JA-mediated defense response|suppression by symbiont of host jasmonic acid-mediated defense response|up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|upregulation by organism of defense-related host SA-mediated signal transduction pathway|upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway|upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway http://purl.obolibrary.org/obo/GO_0052088 GO:0003087 biolink:BiologicalProcess positive regulation of the force of heart contraction by neuronal epinephrine The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction. go.json increased force of heart contraction by epinephrine released from the nerve endings|increased force of heart contraction by neuronal adrenaline|increased force of heart contraction by neuronal epinephrine|positive regulation of heart contraction by adrenaline|positive regulation of heart contraction by neuronal epinephrine http://purl.obolibrary.org/obo/GO_0003087 GO:0003086 biolink:BiologicalProcess regulation of systemic arterial blood pressure by local renal renin-angiotensin The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen. go.json http://purl.obolibrary.org/obo/GO_0003086 GO:0003089 biolink:BiologicalProcess positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream. go.json increased force of heart contraction by circulating adrenaline-noradrenaline|increased force of heart contraction by circulating epinephrine-norepinephrine|increased force of heart contraction by epinephrine-norepinephrine in the blood stream|positive regulation of heart contraction by circulating adrenaline-noradrenaline|positive regulation of heart contraction by circulating epinephrine-norepinephrine http://purl.obolibrary.org/obo/GO_0003089 GO:0003088 biolink:BiologicalProcess positive regulation of the force of heart contraction by circulating epinephrine The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction. go.json increased force of heart contraction by circulating adrenaline|increased force of heart contraction by epinephrine in the bloodstream|positive regulation of heart contraction by circulating adrenaline|positive regulation of heart contraction by circulating epinephrine http://purl.obolibrary.org/obo/GO_0003088 GO:0003083 biolink:BiologicalProcess negative regulation of renal output by angiotensin The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney. go.json angiotensin mediated negative regulation of renal output|angiotensin-mediated negative regulation of renal output http://purl.obolibrary.org/obo/GO_0003083 GO:0003082 biolink:BiologicalProcess obsolete positive regulation of renal output by angiotensin OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney. go.json angiotensin mediated positive regulation of renal output|angiotensin-mediated positive regulation of renal output|positive regulation of renal output by angiotensin True http://purl.obolibrary.org/obo/GO_0003082 GO:0003085 biolink:BiologicalProcess negative regulation of systemic arterial blood pressure The process that reduces the force with which blood travels through the systemic arterial circulatory system. go.json http://purl.obolibrary.org/obo/GO_0003085 GO:0003084 biolink:BiologicalProcess positive regulation of systemic arterial blood pressure The process that increases the force with which blood travels through the systemic arterial circulatory system. go.json http://purl.obolibrary.org/obo/GO_0003084 GO:0052090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052090 GO:0003090 biolink:BiologicalProcess positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings. go.json increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings|increased force of heart contraction by neuronal adrenaline-noradrenaline|increased force of heart contraction by neuronal epinephrine-norepinephrine|positive regulation of heart contraction by adrenaline-noradrenaline|positive regulation of heart contraction by epinephrine-norepinephrine http://purl.obolibrary.org/obo/GO_0003090 GO:0003092 biolink:BiologicalProcess renal water retention The process in which renal water excretion is decreased. go.json negative regulation of renal water excretion http://purl.obolibrary.org/obo/GO_0003092 GO:0003091 biolink:BiologicalProcess renal water homeostasis Renal process involved in the maintenance of an internal steady state of water in the body. go.json water homeostasis by the renal system http://purl.obolibrary.org/obo/GO_0003091 RO:0000057 biolink:OntologyClass has participant RO:0000057 go.json http://purl.obolibrary.org/obo/RO_0000057 GO:0052094 biolink:BiologicalProcess formation of haustorium for nutrient acquisition The assembly of a haustorium, a projection from a symbiotic cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by organism of haustoria for nutrient acquisition from host|formation by organism of haustorium for nutrient acquisition from host|formation by symbiont of haustorium for nutrient acquisition from host http://purl.obolibrary.org/obo/GO_0052094 GO:0052093 biolink:BiologicalProcess formation of specialized structure for nutrient acquisition The assembly of a symbiotic cellular or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by organism of specialized structure for nutrient acquisition from host|formation by symbiont of specialized structure for nutrient acquisition from host|formation of specialized structure for nutrient acquisition from host http://purl.obolibrary.org/obo/GO_0052093 GO:0052092 biolink:BiologicalProcess positive regulation of nutrient release by host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of nutrient release from host|positive regulation by symbiont of nutrient release from host|promotion of nutrient release from host|stimulation by symbiont of nutrient release from host|up regulation by symbiont of nutrient release from host|up-regulation by symbiont of nutrient release from host|upregulation by symbiont of nutrient release from host http://purl.obolibrary.org/obo/GO_0052092 GO:0052091 biolink:BiologicalProcess modulation of nutrient release by host Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of nutrient release from host http://purl.obolibrary.org/obo/GO_0052091 GO:0052098 biolink:BiologicalProcess formation by host of specialized structure for nutrient acquisition from symbiont The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0052098 GO:0052097 biolink:BiologicalProcess obsolete interspecies quorum sensing OBSOLETE. The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules. go.json True http://purl.obolibrary.org/obo/GO_0052097 GO:0052096 biolink:BiologicalProcess formation of syncytium involving giant cell for nutrient acquisition The assembly of a syncytium, a multi-nucleate and physiologically active aggregation of fused root cells induced by a symbiotic nematode in a plant host. The syncytium exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json formation by organism of syncytium involving giant cell for nutrient acquisition from host|formation by symbiont of syncytium involving giant cell for nutrient acquisition from host http://purl.obolibrary.org/obo/GO_0052096 GO:0052095 biolink:BiologicalProcess obsolete formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction OBSOLETE. The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction. go.json formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052095 GO:0052099 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052099 GO:0003058 biolink:BiologicalProcess hormonal regulation of the force of heart contraction The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. go.json hormonal cardiac inotropy|hormonal regulation of the force of heart muscle contraction http://purl.obolibrary.org/obo/GO_0003058 GO:0003057 biolink:BiologicalProcess regulation of the force of heart contraction by chemical signal The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. go.json chemical cardiac inotropy|regulation of the force of heart muscle contraction by chemical signal http://purl.obolibrary.org/obo/GO_0003057 GO:0003059 biolink:BiologicalProcess positive regulation of the force of heart contraction by epinephrine The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction. go.json adrenaline cardiac inotropy|adrenaline regulation of the strength of heart muscle contraction|epinephrine cardiac inotropy|increased force of heart contraction by epinephrine|positive regulation of heart contraction by adrenaline|positive regulation of heart contraction by epinephrine http://purl.obolibrary.org/obo/GO_0003059 GO:0003054 biolink:BiologicalProcess circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours. go.json SCN regulation of blood pressure|master pacemaker clock regulation of blood pressure http://purl.obolibrary.org/obo/GO_0003054 GO:0003053 biolink:BiologicalProcess circadian regulation of heart rate Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours. go.json circadian regulation of heart contraction rate http://purl.obolibrary.org/obo/GO_0003053 GO:0003056 biolink:BiologicalProcess regulation of vascular associated smooth muscle contraction Any process that increases the frequency, rate or extent of vascular smooth muscle contraction. go.json regulation of vascular smooth muscle contraction http://purl.obolibrary.org/obo/GO_0003056 GO:0003055 biolink:BiologicalProcess circadian regulation of heart rate by the suprachiasmatic nucleus The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours. go.json SCN regulation of heart rate|circadian regulation of heart contraction rate by the suprachiasmatic nucleus|master pacemaker clock regulation of heart rate http://purl.obolibrary.org/obo/GO_0003055 GO:0003050 biolink:BiologicalProcess regulation of systemic arterial blood pressure by atrial natriuretic peptide The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide. go.json blood pressure regulation by ANP|blood pressure regulation by atrial natriuretic peptide http://purl.obolibrary.org/obo/GO_0003050 RO:0000056 biolink:OntologyClass participates in RO:0000056 go.json http://purl.obolibrary.org/obo/RO_0000056 GO:0003052 biolink:BiologicalProcess circadian regulation of systemic arterial blood pressure Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours. go.json http://purl.obolibrary.org/obo/GO_0003052 GO:0003051 biolink:BiologicalProcess angiotensin-mediated drinking behavior The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst. go.json angiotensin mediated drinking behavior http://purl.obolibrary.org/obo/GO_0003051 RO:0000053 biolink:OntologyClass bearer of RO:0000053 go.json http://purl.obolibrary.org/obo/RO_0000053 GO:0003069 biolink:BiologicalProcess acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure. go.json vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0003069 GO:0003068 biolink:BiologicalProcess regulation of systemic arterial blood pressure by acetylcholine The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter. go.json blood pressure regulation by acetylcholine http://purl.obolibrary.org/obo/GO_0003068 GO:0003065 biolink:BiologicalProcess positive regulation of heart rate by epinephrine The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction. go.json adrenaline cardiac chronotropy|adrenaline regulation of the rate of heart muscle contraction|epinephrine cardiac chronotropy|positive regulation of heart contraction rate by epinephrine|positive regulation of heart rate by adrenaline http://purl.obolibrary.org/obo/GO_0003065 GO:0003064 biolink:BiologicalProcess regulation of heart rate by hormone The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. go.json hormonal cardiac chronotropy|regulation of the rate of heart contraction by hormone http://purl.obolibrary.org/obo/GO_0003064 GO:0003067 biolink:BiologicalProcess circadian regulation of systemic arterial blood pressure by hormone The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. go.json http://purl.obolibrary.org/obo/GO_0003067 GO:0003066 biolink:BiologicalProcess positive regulation of heart rate by norepinephrine The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction. go.json noradrenaline cardiac chronotropy|noradrenaline regulation of the rate of heart muscle contraction|norepinephrine cardiac chronotropy|positive regulation of heart contraction rate by norepinephrine|positive regulation of heart rate by adrenaline http://purl.obolibrary.org/obo/GO_0003066 GO:0003061 biolink:BiologicalProcess positive regulation of the force of heart contraction by norepinephrine The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction. go.json increased force of heart contraction by adrenaline|increased force of heart contraction by norepinephrine|noradrenaline cardiac inotropy|noradrenaline regulation of the strength of heart muscle contraction|norepinephrine cardiac inotropy|positive regulation of heart contraction by adrenaline|positive regulation of heart contraction by norepinephrine http://purl.obolibrary.org/obo/GO_0003061 GO:0003060 biolink:BiologicalProcess negative regulation of the force of heart contraction by acetylcholine The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction. go.json decreased force of heart contraction by acetylcholine http://purl.obolibrary.org/obo/GO_0003060 GO:0003063 biolink:BiologicalProcess negative regulation of heart rate by acetylcholine The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction. go.json negative regulation of heart contraction rate by acetylcholine http://purl.obolibrary.org/obo/GO_0003063 GO:0003062 biolink:BiologicalProcess regulation of heart rate by chemical signal The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine. go.json chemical cardiac chronotropy|chemical signal regulation of heart contraction rate|chemical signal regulation of heart rate http://purl.obolibrary.org/obo/GO_0003062 GO:0003070 biolink:BiologicalProcess regulation of systemic arterial blood pressure by neurotransmitter The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. go.json http://purl.obolibrary.org/obo/GO_0003070 GO:0042640 biolink:BiologicalProcess anagen The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair. go.json hair growth http://purl.obolibrary.org/obo/GO_0042640 gocheck_do_not_annotate GO:0042642 biolink:CellularComponent actomyosin, myosin complex part The myosin part of any complex of actin, myosin, and accessory proteins. go.json http://purl.obolibrary.org/obo/GO_0042642 GO:0042641 biolink:CellularComponent actomyosin Any complex of actin, myosin, and accessory proteins. go.json actomyosin complex|actomyosin structure http://purl.obolibrary.org/obo/GO_0042641 GO:0042648 biolink:CellularComponent chloroplast chromosome A circular DNA molecule containing chloroplast encoded genes. go.json http://purl.obolibrary.org/obo/GO_0042648 GO:0042647 biolink:CellularComponent proplastid nucleoid The region of a proplastid to which the DNA is confined. go.json http://purl.obolibrary.org/obo/GO_0042647 GO:0042649 biolink:CellularComponent prothylakoid Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light. go.json http://purl.obolibrary.org/obo/GO_0042649 GO:0042644 biolink:CellularComponent chloroplast nucleoid The region of a chloroplast to which the DNA is confined. go.json http://purl.obolibrary.org/obo/GO_0042644 GO:0042643 biolink:CellularComponent obsolete actomyosin, actin portion OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins. go.json True http://purl.obolibrary.org/obo/GO_0042643 GO:0042646 biolink:CellularComponent plastid nucleoid The region of a plastid to which the DNA is confined. go.json http://purl.obolibrary.org/obo/GO_0042646 GO:0042645 biolink:CellularComponent mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined. go.json http://purl.obolibrary.org/obo/GO_0042645 GO:0042651 biolink:CellularComponent thylakoid membrane The pigmented membrane of any thylakoid. go.json http://purl.obolibrary.org/obo/GO_0042651 GO:0042650 biolink:CellularComponent prothylakoid membrane The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. go.json http://purl.obolibrary.org/obo/GO_0042650 GO:0042653 biolink:CellularComponent mitochondrial respiratory chain complex I, membrane segment The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. go.json NADH-Q oxidoreductase complex, membrane segment http://purl.obolibrary.org/obo/GO_0042653 GO:0042652 biolink:CellularComponent mitochondrial respiratory chain complex I, peripheral segment The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. go.json NADH dehydrogenase (ubiquinone) complex, peripheral segment|NADH-Q oxidoreductase complex, peripheral segment http://purl.obolibrary.org/obo/GO_0042652 GO:0042659 biolink:BiologicalProcess regulation of cell fate specification Any process that mediates the adoption of a specific fate by a cell. go.json http://purl.obolibrary.org/obo/GO_0042659 GO:0042658 biolink:MolecularActivity MHC class II protein binding, via antigen binding groove Binding to the antigen binding groove of major histocompatibility complex class II molecules. go.json major histocompatibility complex class II protein binding, via antigen binding groove http://purl.obolibrary.org/obo/GO_0042658 GO:0042655 biolink:BiologicalProcess obsolete activation of JNKKK activity OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity. go.json activation of JUN kinase kinase kinase activity|positive regulation of JUNKKK activity True http://purl.obolibrary.org/obo/GO_0042655 GO:0042654 biolink:MolecularActivity ecdysis-triggering hormone receptor activity Combining with ecdysis-triggering hormone to initiate a change in cell activity. go.json ETH receptor|ecdysis-triggering hormone binding http://purl.obolibrary.org/obo/GO_0042654 GO:0042657 biolink:MolecularActivity MHC class II protein binding, via lateral surface Binding to the lateral surface of major histocompatibility complex class II molecules. go.json major histocompatibility complex class II protein binding, via lateral surface http://purl.obolibrary.org/obo/GO_0042657 GO:0042656 biolink:MolecularActivity JUN kinase kinase kinase kinase activity Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs). go.json JUNKKKK activity http://purl.obolibrary.org/obo/GO_0042656 GO:0042662 biolink:BiologicalProcess negative regulation of mesodermal cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification. go.json down regulation of mesodermal cell fate specification|down-regulation of mesodermal cell fate specification|downregulation of mesodermal cell fate specification|inhibition of mesodermal cell fate specification|suppression of mesodermal cell fate http://purl.obolibrary.org/obo/GO_0042662 GO:0042661 biolink:BiologicalProcess regulation of mesodermal cell fate specification Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. go.json http://purl.obolibrary.org/obo/GO_0042661 GO:0042664 biolink:BiologicalProcess negative regulation of endodermal cell fate specification Any process that restricts, stops or prevents a cell from specifying into an endoderm cell. go.json down regulation of endodermal cell fate specification|down-regulation of endodermal cell fate specification|downregulation of endodermal cell fate specification|inhibition of endodermal cell fate specification|negative regulation of endoderm cell fate specification|suppression of endoderm cell fate|suppression of endodermal cell fate http://purl.obolibrary.org/obo/GO_0042664 GO:0042663 biolink:BiologicalProcess regulation of endodermal cell fate specification Any process that mediates the specification of a cell into an endoderm cell. go.json regulation of endoderm cell fate specification http://purl.obolibrary.org/obo/GO_0042663 GO:0042660 biolink:BiologicalProcess positive regulation of cell fate specification Any process that activates or enables a cell to adopt a specific fate. go.json activation of cell fate specification|stimulation of cell fate specification|up regulation of cell fate specification|up-regulation of cell fate specification|upregulation of cell fate specification http://purl.obolibrary.org/obo/GO_0042660 GO:0042669 biolink:BiologicalProcess regulation of inner ear auditory receptor cell fate specification Any process that mediates the specification of a cell into an auditory hair cell. go.json regulation of auditory hair cell fate specification http://purl.obolibrary.org/obo/GO_0042669 GO:0042666 biolink:BiologicalProcess negative regulation of ectodermal cell fate specification Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell. go.json down regulation of ectodermal cell fate specification|down-regulation of ectodermal cell fate specification|downregulation of ectodermal cell fate specification|inhibition of ectodermal cell fate specification|negative regulation of ectoderm cell fate specification|suppression of ectoderm cell fate|suppression of ectodermal cell fate http://purl.obolibrary.org/obo/GO_0042666 GO:0042665 biolink:BiologicalProcess regulation of ectodermal cell fate specification Any process that mediates the specification of a cell into an ectoderm cell. go.json regulation of ectoderm cell fate specification http://purl.obolibrary.org/obo/GO_0042665 GO:0042668 biolink:BiologicalProcess auditory receptor cell fate determination The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json auditory hair cell fate determination http://purl.obolibrary.org/obo/GO_0042668 GO:0042667 biolink:BiologicalProcess auditory receptor cell fate specification The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json auditory hair cell fate specification http://purl.obolibrary.org/obo/GO_0042667 GO:0042673 biolink:BiologicalProcess regulation of retinal cone cell fate specification Any process that mediates the specification of a cell into a retinal cone cell. go.json http://purl.obolibrary.org/obo/GO_0042673 GO:0042672 biolink:BiologicalProcess retinal cone cell fate specification The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0042672 GO:0042675 biolink:BiologicalProcess compound eye cone cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye. go.json http://purl.obolibrary.org/obo/GO_0042675 GO:0042674 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042674 GO:0042671 biolink:BiologicalProcess retinal cone cell fate determination The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0042671 GO:0042670 biolink:BiologicalProcess retinal cone cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. go.json http://purl.obolibrary.org/obo/GO_0042670 GO:0042677 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042677 GO:0042676 biolink:BiologicalProcess compound eye cone cell fate commitment The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type. go.json http://purl.obolibrary.org/obo/GO_0042676 GO:0042679 biolink:BiologicalProcess compound eye cone cell fate specification The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0042679 GO:0042678 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042678 GO:0052007 biolink:BiologicalProcess obsolete biosynthesis by symbiont of substance in host OBSOLETE. The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json biosynthesis by organism of substance in host True http://purl.obolibrary.org/obo/GO_0052007 GO:0052006 biolink:BiologicalProcess obsolete catabolism by symbiont of substance in host OBSOLETE. The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of substance in host True http://purl.obolibrary.org/obo/GO_0052006 GO:0052005 biolink:BiologicalProcess suppression by symbiont of host ethylene-mediated defense response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host ethylene-mediated defense response|down-regulation by symbiont of host ethylene-mediated defense response|downregulation by symbiont of host ethylene-mediated defense response|inhibition by symbiont of host ethylene-mediated defense response|negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction|negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway|negative regulation by symbiont of host ethylene-mediated defense response|suppression by organism of host ethylene-mediated defense response http://purl.obolibrary.org/obo/GO_0052005 GO:0052004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052004 GO:0052009 biolink:BiologicalProcess symbiont-mediated disruption of host cell wall The process in which an organism effects a change that impairs the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disassembly by symbiont of host cell wall|disruption by symbiont of host cell wall http://purl.obolibrary.org/obo/GO_0052009 GO:0052008 biolink:BiologicalProcess symbiont-mediated disruption of host cellular anatomical entity The process in which an organism effects a change that impairs the structure or function of a host cellular anatomical entity. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism of host cellular component by organism|catabolism of host structural constituent by organism|degradation of host cellular component by organism|disassembly by organism of host cellular component|disassembly by symbiont of host cellular component|disruption by symbiont of host cellular component|symbiont-mediated disruption of host cellular component http://purl.obolibrary.org/obo/GO_0052008 GO:0042684 biolink:BiologicalProcess cardioblast cell fate commitment The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0042684 GO:0042683 biolink:BiologicalProcess negative regulation of compound eye cone cell fate specification Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell. go.json down regulation of cone cell fate specification|down-regulation of cone cell fate specification|downregulation of cone cell fate specification|inhibition of cone cell fate specification|suppression of cone cell fate http://purl.obolibrary.org/obo/GO_0042683 GO:0042686 biolink:BiologicalProcess regulation of cardioblast cell fate specification Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0042686 GO:0042685 biolink:BiologicalProcess cardioblast cell fate specification The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0042685 GO:0042680 biolink:BiologicalProcess compound eye cone cell fate determination The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0042680 GO:0042682 biolink:BiologicalProcess regulation of compound eye cone cell fate specification Any process that mediates the specification of a cell into a compound eye cone cell. go.json http://purl.obolibrary.org/obo/GO_0042682 GO:0042681 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042681 GO:0042688 biolink:BiologicalProcess crystal cell differentiation The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. go.json http://purl.obolibrary.org/obo/GO_0042688 GO:0042687 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042687 GO:0042689 biolink:BiologicalProcess regulation of crystal cell differentiation Any process that modulates the frequency, rate or extent of crystal cell differentiation. go.json http://purl.obolibrary.org/obo/GO_0042689 GO:0052003 biolink:BiologicalProcess symbiont-mediated suppression of defense-related host salicylic acid-mediated signal transduction pathway A process in which a virus interferes with, inhibits or disrupts a host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption of defense-related host salicylic acid-mediated signal transduction pathway|down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|down regulation by symbiont of host salicylic acid-mediated defense response|down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|down-regulation by symbiont of host salicylic acid-mediated defense response|downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|downregulation by symbiont of host salicylic acid-mediated defense response|inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|inhibition by symbiont of host salicylic acid-mediated defense response|negative modulation by organism of defense-related host SA-mediated signal transduction pathway|negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway|negative regulation by organism of defense-related host SA-mediated signal transduction pathway|negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction|negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction|negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|negative regulation by symbiont of host salicylic acid-mediated defense response|negative regulation of host SA-mediated defense response|suppression by organism of host salicylic acid-mediated defense response|suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|suppression of host SA mediated defense response http://purl.obolibrary.org/obo/GO_0052003 GO:0052002 biolink:BiologicalProcess obsolete metabolism by symbiont of substance in host OBSOLETE. The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052002 GO:0052001 biolink:BiologicalProcess adhesion to host cell via type IV pili Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json type IV pili-dependent localized adherence to host http://purl.obolibrary.org/obo/GO_0052001 GO:0052000 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052000 GO:0052018 biolink:BiologicalProcess obsolete modulation by symbiont of RNA levels in host OBSOLETE. The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host RNA levels True http://purl.obolibrary.org/obo/GO_0052018 GO:0052017 biolink:BiologicalProcess obsolete catabolism by symbiont of host xylan OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host xylan True http://purl.obolibrary.org/obo/GO_0052017 GO:0052016 biolink:BiologicalProcess obsolete catabolism by symbiont of host glucan OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host glucan True http://purl.obolibrary.org/obo/GO_0052016 GO:0052015 biolink:BiologicalProcess obsolete catabolism by symbiont of host carbohydrate OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host carbohydrate True http://purl.obolibrary.org/obo/GO_0052015 GO:0052019 biolink:BiologicalProcess modulation by symbiont of host hormone or growth regulator levels The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052019 GO:0042695 biolink:BiologicalProcess thelarche The beginning of development of the breasts in the female. Wikipedia:Thelarche go.json http://purl.obolibrary.org/obo/GO_0042695 GO:0042694 biolink:BiologicalProcess muscle cell fate specification The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0042694 GO:0042697 biolink:BiologicalProcess menopause Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50. Wikipedia:Menopause go.json http://purl.obolibrary.org/obo/GO_0042697 gocheck_do_not_annotate GO:0042696 biolink:BiologicalProcess menarche The beginning of the menstrual cycle; the first menstrual cycle in an individual. Wikipedia:Menarche go.json http://purl.obolibrary.org/obo/GO_0042696 gocheck_do_not_annotate GO:0042691 biolink:BiologicalProcess positive regulation of crystal cell differentiation Any process that activates or increases the frequency, rate or extent of crystal cell differentiation. go.json activation of crystal cell differentiation|stimulation of crystal cell differentiation|up regulation of crystal cell differentiation|up-regulation of crystal cell differentiation|upregulation of crystal cell differentiation http://purl.obolibrary.org/obo/GO_0042691 GO:0042690 biolink:BiologicalProcess negative regulation of crystal cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation. go.json down regulation of crystal cell differentiation|down-regulation of crystal cell differentiation|downregulation of crystal cell differentiation|inhibition of crystal cell differentiation http://purl.obolibrary.org/obo/GO_0042690 GO:0042693 biolink:BiologicalProcess muscle cell fate commitment The process in which the cellular identity of muscle cells is acquired and determined. go.json http://purl.obolibrary.org/obo/GO_0042693 GO:0042692 biolink:BiologicalProcess muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. go.json myogenesis http://purl.obolibrary.org/obo/GO_0042692 GO:0042699 biolink:BiologicalProcess follicle-stimulating hormone signaling pathway A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json follicle stimulating hormone signaling pathway|follicle stimulating hormone signalling pathway|follicle-stimulating hormone signalling pathway http://purl.obolibrary.org/obo/GO_0042699 GO:0042698 biolink:BiologicalProcess ovulation cycle The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. go.json http://purl.obolibrary.org/obo/GO_0042698 GO:0052010 biolink:BiologicalProcess obsolete catabolism by symbiont of host cell wall cellulose OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host cell wall cellulose True http://purl.obolibrary.org/obo/GO_0052010 GO:0052014 biolink:BiologicalProcess obsolete catabolism by symbiont of host protein OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host protein True http://purl.obolibrary.org/obo/GO_0052014 GO:0052013 biolink:BiologicalProcess obsolete catabolism by symbiont of host macromolecule OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host macromolecule True http://purl.obolibrary.org/obo/GO_0052013 GO:0052012 biolink:BiologicalProcess obsolete catabolism by symbiont of host cell wall chitin OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host cell wall chitin True http://purl.obolibrary.org/obo/GO_0052012 GO:0052011 biolink:BiologicalProcess obsolete catabolism by symbiont of host cell wall pectin OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json catabolism by organism of host cell wall pectin True http://purl.obolibrary.org/obo/GO_0052011 GO:0052029 biolink:BiologicalProcess symbiont-mediated suppression of host signal transduction pathway A process in which a symbiont interferes with, inhibits or disrupts a host signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host signal transduction pathway|disruption of host signal transduction pathway|down regulation by symbiont of host signal transduction pathway|down-regulation by symbiont of host signal transduction pathway|downregulation by symbiont of host signal transduction pathway|inhibition by symbiont of host signal transduction pathway|negative modulation by organism of host signal transduction pathway|negative regulation by organism of signal transduction in other organism involved in symbiotic interaction|negative regulation by symbiont of host signal transduction pathway|suppression by symbiont of host signal transduction pathway http://purl.obolibrary.org/obo/GO_0052029 GO:0052028 biolink:BiologicalProcess symbiont-mediated activation of host signal transduction pathway A process in which a symbiont subverts a signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host signal transduction pathway|induction by symbiont of host signal transduction pathway|positive regulation by organism of signal transduction in other organism involved in symbiotic interaction|positive regulation by symbiont of host signal transduction pathway|positive regulation of signal transduction in other organism|stimulation by symbiont of host signal transduction pathway|up regulation by symbiont of host signal transduction pathway|up-regulation by symbiont of host signal transduction pathway|upregulation by symbiont of host signal transduction pathway http://purl.obolibrary.org/obo/GO_0052028 GO:0052027 biolink:BiologicalProcess perturbation of host signal transduction pathway A process in which a symbiont alters or subverts a signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host signal transduction|modulation by symbiont of host signal transduction pathway|modulation of host signal transduction by symbiont|modulation of signal transduction in other organism involved in symbiotic interaction|regulation by symbiont of host signal transduction pathway http://purl.obolibrary.org/obo/GO_0052027 GO:0052026 biolink:BiologicalProcess modulation by symbiont of host transcription Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0052026 GO:0052021 biolink:BiologicalProcess modulation by symbiont of ethylene levels in host The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of ethylene levels in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052021 GO:0052020 biolink:BiologicalProcess obsolete modification by symbiont of host cell wall OBSOLETE. The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json metabolism of host cell wall by organism True http://purl.obolibrary.org/obo/GO_0052020 GO:0052025 biolink:BiologicalProcess symbiont-mediated perturbation of host cell endomembrane system The process in which an organism effects a change that impairs the structure or function of the host endomembrane system. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host cell membrane|modification by symbiont of host cell membrane|symbiont-mediated disruption of host cell membrane|symbiont-mediated perturbation of host cell membrane http://purl.obolibrary.org/obo/GO_0052025 GO:0052024 biolink:BiologicalProcess positive regulation by symbiont of hormone or growth regulator levels in host The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of hormone or growth regulator levels in host|positive modulation of hormone or growth regulator levels in host|positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction|stimulation by symbiont of hormone or growth regulator levels in host|up regulation by symbiont of hormone or growth regulator levels in host|up-regulation by symbiont of hormone or growth regulator levels in host|upregulation by symbiont of hormone or growth regulator levels in host http://purl.obolibrary.org/obo/GO_0052024 GO:0052023 biolink:BiologicalProcess modulation by symbiont of salicylic acid levels in host The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052023 GO:0052022 biolink:BiologicalProcess modulation by symbiont of jasmonic acid levels in host The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052022 GO:0052039 biolink:BiologicalProcess symbiont-mediated perturbation of host cytoskeleton The process in which an organism effects a change that impairs the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host cytoskeleton|modification by symbiont of host cytoskeleton|perturbation by symbiont of host cytoskeleton|rounding by symbiont of host cells http://purl.obolibrary.org/obo/GO_0052039 GO:0052038 biolink:BiologicalProcess modulation by symbiont of host intracellular transport Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation of host intracellular trafficking http://purl.obolibrary.org/obo/GO_0052038 GO:0052037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052037 GO:0052032 biolink:BiologicalProcess perturbation by symbiont of host inflammatory response Any process in which a symbiont modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of inflammatory response of other organism involved in symbiotic interaction|modulation by symbiont of host inflammatory response http://purl.obolibrary.org/obo/GO_0052032 GO:0052031 biolink:BiologicalProcess symbiont-mediated perturbation of host defense response A process in which a symbiont interferes with the ability of the host to mount a defense in response to its presence. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json mitigation by symbiont of host defense response|modulation by organism of defense response of other organism involved in symbiotic interaction|modulation by symbiont of host defense response|pathogenesis|perturbation by symbiont of host defense response http://purl.obolibrary.org/obo/GO_0052031 GO:0052030 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052030 GO:0052036 biolink:BiologicalProcess suppression by symbiont of host inflammatory response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host inflammatory response|down-regulation by symbiont of host inflammatory response|downregulation by symbiont of host inflammatory response|inhibition by symbiont of host inflammatory response|negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction|negative regulation by symbiont of host inflammatory response http://purl.obolibrary.org/obo/GO_0052036 GO:0052035 biolink:BiologicalProcess obsolete positive regulation by symbiont of host inflammatory response OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host inflammatory response|positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction|stimulation by symbiont of host inflammatory response|up regulation by symbiont of host inflammatory response|up-regulation by symbiont of host inflammatory response|upregulation by symbiont of host inflammatory response True http://purl.obolibrary.org/obo/GO_0052035 GO:0052034 biolink:BiologicalProcess effector-mediated suppression of host pattern-triggered immunity A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity|down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity|downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity|inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity|negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction|negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response|negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity|suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response|suppression of MAMP induced host innate immunity|suppression of MAMP-induced host innate immunity|suppression of PAMP induced host innate immunity|suppression of PAMP-induced host innate immunity|suppression of general elicitor induced host innate immunity|suppression of general elicitor-induced host innate immunity|suppression of pathogen-associated molecular pattern-induced host innate immunity http://purl.obolibrary.org/obo/GO_0052034 GO:0052033 biolink:BiologicalProcess obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json MAMP dependent activation of host innate immunity|MAMP dependent induction of host innate immunity|PAMP dependent activation of host innate immunity|PAMP dependent induction of host innate immunity|PTI|general elicitor-dependent activation of host innate immunity|general elicitor-dependent induction of host innate immunity|pathogen-associated molecular pattern dependent activation by organism of host innate immunity|pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity|pattern-triggered immunity True http://purl.obolibrary.org/obo/GO_0052033 GO:0042604 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042604 GO:0042603 biolink:CellularComponent capsule A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication. Wikipedia:Capsule_(microbiology) go.json http://purl.obolibrary.org/obo/GO_0042603 GO:0042606 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042606 GO:0042605 biolink:MolecularActivity peptide antigen binding Binding to an antigen peptide. go.json endogenous peptide antigen binding|exogenous peptide antigen binding http://purl.obolibrary.org/obo/GO_0042605 goslim_chembl GO:0042600 biolink:CellularComponent egg chorion A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish. go.json http://purl.obolibrary.org/obo/GO_0042600 goslim_pir GO:0042602 biolink:MolecularActivity riboflavin reductase (NADPH) activity Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. EC:1.5.1.30|KEGG_REACTION:R05707|MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN|RHEA:19377 go.json FMN reductase (NADPH) activity|NADPH dehydrogenase (riboflavin) activity|NADPH-FMN reductase activity|NADPH-dependent FMN reductase activity|NADPH-riboflavin oxidoreductase activity|NADPH-riboflavin reductase activity|NADPH-specific FMN reductase activity|NADPH:riboflavin oxidoreductase activity|flavin reductase activity|reduced-riboflavin:NADP+ oxidoreductase activity|riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|riboflavin mononucleotide reductase activity|riboflavine mononucleotide reductase activity http://purl.obolibrary.org/obo/GO_0042602 GO:0042601 biolink:CellularComponent endospore-forming forespore Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions. go.json http://purl.obolibrary.org/obo/GO_0042601 GO:0042608 biolink:MolecularActivity T cell receptor binding Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. go.json T lymphocyte receptor binding|T-cell receptor binding|T-lymphocyte receptor binding|TCR binding http://purl.obolibrary.org/obo/GO_0042608 GO:0042607 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042607 GO:0042609 biolink:MolecularActivity CD4 receptor binding Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. go.json http://purl.obolibrary.org/obo/GO_0042609 GO:0042615 biolink:MolecularActivity CD154 receptor binding Binding to CD154, a receptor found on the surface of some activated lymphocytes. go.json CD40 receptor activity|CD40L binding http://purl.obolibrary.org/obo/GO_0042615 GO:0042614 biolink:MolecularActivity CD70 receptor binding Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells. go.json CD27 receptor activity|CD27L binding http://purl.obolibrary.org/obo/GO_0042614 GO:0042617 biolink:BiologicalProcess paclitaxel biosynthetic process The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. go.json paclitaxel anabolism|paclitaxel biosynthesis|paclitaxel formation|paclitaxel metabolic process|paclitaxel metabolism|paclitaxel synthesis|taxol biosynthesis|taxol biosynthetic process|taxol metabolic process|taxol metabolism http://purl.obolibrary.org/obo/GO_0042617 GO:0042616 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042616 GO:0042611 biolink:CellularComponent MHC protein complex A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. go.json http://purl.obolibrary.org/obo/GO_0042611 goslim_pir GO:0042610 biolink:MolecularActivity CD8 receptor binding Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. go.json http://purl.obolibrary.org/obo/GO_0042610 GO:0042613 biolink:CellularComponent MHC class II protein complex A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. go.json http://purl.obolibrary.org/obo/GO_0042613 GO:0042612 biolink:CellularComponent MHC class I protein complex A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. go.json http://purl.obolibrary.org/obo/GO_0042612 GO:0042619 biolink:BiologicalProcess poly-hydroxybutyrate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells. go.json PHB biosynthesis|PHB biosynthetic process|poly-hydroxybutyrate anabolism|poly-hydroxybutyrate biosynthesis|poly-hydroxybutyrate formation|poly-hydroxybutyrate synthesis http://purl.obolibrary.org/obo/GO_0042619 GO:0042618 biolink:BiologicalProcess poly-hydroxybutyrate metabolic process The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells. go.json PHB metabolic process|PHB metabolism|poly-hydroxybutyrate metabolism http://purl.obolibrary.org/obo/GO_0042618 GO:0042620 biolink:BiologicalProcess poly(3-hydroxyalkanoate) metabolic process The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. go.json PHA metabolic process|PHA metabolism|poly(3-hydroxyalkanoate) metabolism http://purl.obolibrary.org/obo/GO_0042620 goslim_pir GO:0042626 biolink:MolecularActivity ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. EC:7.2.2.-|Reactome:R-HSA-1467457|Reactome:R-HSA-2161506|Reactome:R-HSA-2161538|Reactome:R-HSA-9033499|Reactome:R-HSA-9033505|Reactome:R-HSA-9659680|Reactome:R-HSA-9750546|Reactome:R-HSA-9750617|Reactome:R-HSA-9753278|Reactome:R-HSA-9753283|Reactome:R-HSA-9753284|Reactome:R-HSA-9759454|Reactome:R-HSA-9759461|Reactome:R-HSA-9794120|Reactome:R-HSA-9794572 go.json ATP-coupled transmembrane transporter activity|ATP-dependent transmembrane transporter activity|ATPase activity, coupled to movement of substances|ATPase activity, coupled to transmembrane movement of substances|P-P-bond-hydrolysis-driven transmembrane transporter activity|P-P-bond-hydrolysis-driven transporter|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances http://purl.obolibrary.org/obo/GO_0042626 GO:0042625 biolink:MolecularActivity ATPase-coupled ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. go.json ATP-dependent ion transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of ions|ATPase coupled ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0042625 GO:0042628 biolink:BiologicalProcess mating plug formation The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males. go.json copulatory plug biosynthesis|copulatory plug deposition|copulatory plug formation|mating plug deposition http://purl.obolibrary.org/obo/GO_0042628 GO:0042627 biolink:CellularComponent chylomicron A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. Wikipedia:Chylomicron go.json http://purl.obolibrary.org/obo/GO_0042627 GO:0042622 biolink:CellularComponent photoreceptor outer segment membrane The membrane surrounding the outer segment of a vertebrate photoreceptor. go.json http://purl.obolibrary.org/obo/GO_0042622 GO:0042621 biolink:BiologicalProcess poly(3-hydroxyalkanoate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. go.json PHA biosynthesis|PHA biosynthetic process|poly(3-hydroxyalkanoate) anabolism|poly(3-hydroxyalkanoate) biosynthesis|poly(3-hydroxyalkanoate) formation|poly(3-hydroxyalkanoate) synthesis http://purl.obolibrary.org/obo/GO_0042621 GO:0042624 biolink:MolecularActivity obsolete ATPase activity, uncoupled OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction. go.json True http://purl.obolibrary.org/obo/GO_0042624 GO:0042623 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042623 GO:0042629 biolink:CellularComponent mast cell granule Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. go.json http://purl.obolibrary.org/obo/GO_0042629 GO:0042631 biolink:BiologicalProcess cellular response to water deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water. go.json cellular response to drought http://purl.obolibrary.org/obo/GO_0042631 GO:0042630 biolink:BiologicalProcess behavioral response to water deprivation Any process that results in a change in the behavior of an organism as a result of deprivation of water. go.json behavioral response to drought|behavioral response to thirst|behavioural response to water deprivation http://purl.obolibrary.org/obo/GO_0042630 GO:0042637 biolink:BiologicalProcess catagen The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced. go.json hair regression http://purl.obolibrary.org/obo/GO_0042637 gocheck_do_not_annotate GO:0042636 biolink:BiologicalProcess negative regulation of hair cycle Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. go.json down regulation of hair cycle|down-regulation of hair cycle|downregulation of hair cycle|inhibition of hair cycle http://purl.obolibrary.org/obo/GO_0042636 GO:0042639 biolink:BiologicalProcess telogen The resting phase of hair cycle. go.json hair resting phase http://purl.obolibrary.org/obo/GO_0042639 gocheck_do_not_annotate GO:0042638 biolink:BiologicalProcess exogen The shedding phase of the hair cycle. go.json hair shedding http://purl.obolibrary.org/obo/GO_0042638 gocheck_do_not_annotate GO:0042633 biolink:BiologicalProcess hair cycle The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. go.json http://purl.obolibrary.org/obo/GO_0042633 GO:0042632 biolink:BiologicalProcess cholesterol homeostasis Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. go.json positive regulation of cholesterol homeostasis|regulation of cholesterol homeostasis http://purl.obolibrary.org/obo/GO_0042632 GO:0042635 biolink:BiologicalProcess positive regulation of hair cycle Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. go.json activation of hair cycle|stimulation of hair cycle|up regulation of hair cycle|up-regulation of hair cycle|upregulation of hair cycle http://purl.obolibrary.org/obo/GO_0042635 GO:0042634 biolink:BiologicalProcess regulation of hair cycle Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. go.json http://purl.obolibrary.org/obo/GO_0042634 GO:0003039 biolink:BiologicalProcess detection of reduced oxygen by carotid body chemoreceptor signaling The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body. go.json detection of reduced oxygen by carotid body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003039 GO:0003036 biolink:BiologicalProcess detection of pH by aortic body chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body. go.json detection of pH by aortic body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003036 GO:0003035 biolink:BiologicalProcess detection of increased carbon dioxide by carotid body chemoreceptor signaling The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body. go.json detection of increased carbon dioxide by carotid body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003035 GO:0003038 biolink:BiologicalProcess detection of reduced oxygen by aortic body chemoreceptor signaling The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body. go.json detection of reduced oxygen by aortic body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003038 GO:0003037 biolink:BiologicalProcess detection of pH by carotid body chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body. go.json detection of pH by carotid body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003037 GO:0003032 biolink:BiologicalProcess detection of oxygen The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0003032 GO:0003031 biolink:BiologicalProcess detection of carbon dioxide The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0003031 GO:0003034 biolink:BiologicalProcess detection of increased carbon dioxide by aortic body chemoreceptor signaling The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body. go.json detection of increased carbon dioxide by aortic body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003034 GO:0003033 biolink:BiologicalProcess detection of hypoxic conditions in blood by aortic body chemoreceptor signaling The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies. go.json detection of hypoxic conditions in blood by aortic body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003033 GO:0003030 biolink:BiologicalProcess detection of hydrogen ion The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0003030 GO:0003047 biolink:BiologicalProcess regulation of systemic arterial blood pressure by epinephrine The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine. go.json blood pressure regulation by epinephrine|regulation of blood pressure by adrenaline http://purl.obolibrary.org/obo/GO_0003047 GO:0003046 biolink:BiologicalProcess regulation of systemic arterial blood pressure by stress relaxation The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs. go.json blood pressure regulation by stress relaxation http://purl.obolibrary.org/obo/GO_0003046 GO:0003049 biolink:BiologicalProcess regulation of systemic arterial blood pressure by capillary fluid shift The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment. go.json blood pressure regulation by capillary fluid shift http://purl.obolibrary.org/obo/GO_0003049 GO:0003048 biolink:BiologicalProcess regulation of systemic arterial blood pressure by norepinephrine The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine. go.json blood pressure regulation by norepinephrine|regulation of blood pressure by noradrenaline http://purl.obolibrary.org/obo/GO_0003048 GO:0003043 biolink:BiologicalProcess vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. go.json vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0003043 GO:0003042 biolink:BiologicalProcess vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. go.json vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0003042 GO:0003045 biolink:BiologicalProcess regulation of systemic arterial blood pressure by physical factors The regulation of blood pressure mediated by detection of forces within the circulatory system. go.json blood pressure regulation by physical factors http://purl.obolibrary.org/obo/GO_0003045 GO:0003044 biolink:BiologicalProcess regulation of systemic arterial blood pressure mediated by a chemical signal The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. go.json blood pressure regulation mediated by a chemical signal http://purl.obolibrary.org/obo/GO_0003044 GO:0003041 biolink:BiologicalProcess excitation of vasomotor center by carotid body chemoreceptor signaling The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. go.json excitation of vasomotor center by carotid body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003041 GO:0003040 biolink:BiologicalProcess excitation of vasomotor center by aortic body chemoreceptor signaling The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. go.json excitation of vasomotor center by aortic body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003040 GO:0003018 biolink:BiologicalProcess vascular process in circulatory system A circulatory process that occurs at the level of the vasculature. go.json vasculature process http://purl.obolibrary.org/obo/GO_0003018 GO:0003017 biolink:BiologicalProcess lymph circulation The flow of lymph through the body of an animal. go.json http://purl.obolibrary.org/obo/GO_0003017 GO:0003019 biolink:BiologicalProcess central nervous system control of baroreceptor feedback The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris. go.json http://purl.obolibrary.org/obo/GO_0003019 GO:0003014 biolink:BiologicalProcess renal system process A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). go.json excretory system process|kidney system process http://purl.obolibrary.org/obo/GO_0003014 goslim_generic GO:0003013 biolink:BiologicalProcess circulatory system process A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. Wikipedia:Circulatory_system go.json http://purl.obolibrary.org/obo/GO_0003013 goslim_chembl|goslim_generic GO:0003016 biolink:BiologicalProcess respiratory system process A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. go.json respiratory gaseous exchange http://purl.obolibrary.org/obo/GO_0003016 goslim_generic GO:0003015 biolink:BiologicalProcess heart process A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. go.json cardiac process http://purl.obolibrary.org/obo/GO_0003015 GO:0003010 biolink:BiologicalProcess voluntary skeletal muscle contraction A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control. go.json http://purl.obolibrary.org/obo/GO_0003010 GO:0003012 biolink:BiologicalProcess muscle system process A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. go.json muscle physiological process http://purl.obolibrary.org/obo/GO_0003012 goslim_drosophila|goslim_generic GO:0003011 biolink:BiologicalProcess involuntary skeletal muscle contraction A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control. go.json http://purl.obolibrary.org/obo/GO_0003011 GO:0003029 biolink:BiologicalProcess detection of hypoxic conditions in blood by carotid body chemoreceptor signaling The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies. go.json detection of hypoxic conditions in blood by carotid body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003029 GO:0003028 biolink:BiologicalProcess regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. go.json aortic body chemoreceptor regulation of systemic arterial blood pressure|aortic body chemoreceptor response to lowering of systemic arterial blood pressure|regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003028 GO:0003025 biolink:BiologicalProcess regulation of systemic arterial blood pressure by baroreceptor feedback The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control. go.json baroreceptor regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0003025 GO:0003024 biolink:BiologicalProcess baroreceptor detection of decreased arterial stretch The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0003024 GO:0003027 biolink:BiologicalProcess regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. go.json carotid body chemoreceptor regulation of systemic arterial blood pressure|carotid body chemoreceptor response to lowering of systemic arterial blood pressure|regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling|vagal reflex http://purl.obolibrary.org/obo/GO_0003027 GO:0003026 biolink:BiologicalProcess regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control. go.json aortic arch baroreceptor control of systemic arterial blood pressure http://purl.obolibrary.org/obo/GO_0003026 GO:0003021 biolink:BiologicalProcess detection of increased carbon dioxide by chemoreceptor signaling The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. go.json detection of increased carbon dioxide by chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003021 GO:0003020 biolink:BiologicalProcess detection of reduced oxygen by chemoreceptor signaling The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. go.json detection of reduced oxygen by chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003020 GO:0003023 biolink:BiologicalProcess baroreceptor detection of increased arterial stretch The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0003023 GO:0003022 biolink:BiologicalProcess detection of pH by chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors. go.json detection of pH by chemoreceptor signalling http://purl.obolibrary.org/obo/GO_0003022 GO:0003007 biolink:BiologicalProcess heart morphogenesis The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. go.json cardiac morphogenesis http://purl.obolibrary.org/obo/GO_0003007 GO:0003006 biolink:BiologicalProcess developmental process involved in reproduction A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. go.json puberty|reproductive developmental process http://purl.obolibrary.org/obo/GO_0003006 GO:0003009 biolink:BiologicalProcess skeletal muscle contraction A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. go.json http://purl.obolibrary.org/obo/GO_0003009 GO:0003008 biolink:BiologicalProcess system process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. go.json organ system process http://purl.obolibrary.org/obo/GO_0003008 GO:0003003 biolink:BiologicalProcess follicular fluid formation in ovarian follicle antrum involved in fused antrum stage The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis. go.json follicular fluid formation in ovarian follicle antrum during fused antrum stage http://purl.obolibrary.org/obo/GO_0003003 GO:0003002 biolink:BiologicalProcess regionalization The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. go.json pattern formation http://purl.obolibrary.org/obo/GO_0003002 GO:0003005 biolink:BiologicalProcess follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis. go.json follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage http://purl.obolibrary.org/obo/GO_0003005 GO:0003004 biolink:BiologicalProcess follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis. go.json follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage http://purl.obolibrary.org/obo/GO_0003004 GO:0003001 biolink:BiologicalProcess obsolete generation of a signal involved in cell-cell signaling OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal. go.json formation of a signal|generation of a signal involved in cell-cell signaling|generation of a signal involved in cell-cell signalling|signal generation True http://purl.obolibrary.org/obo/GO_0003001 GO:0052169 biolink:BiologicalProcess obsolete pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity True http://purl.obolibrary.org/obo/GO_0052169 GO:0052160 biolink:BiologicalProcess perturbation of host systemic acquired resistance A process in which an organism effects a change that affects systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction|modulation by symbiont of host systemic acquired resistance|modulation by symbiont of systemic acquired resistance in host http://purl.obolibrary.org/obo/GO_0052160 GO:0052164 biolink:BiologicalProcess symbiont defense to host-produced reactive oxygen species A process in which a symbiont alters or subverts either the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response. go.json evasion by symbiont of cellular damage caused by host oxidative burst|evasion or tolerance by organism of host-produced reactive oxygen species|evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction|evasion or tolerance by organism of reactive oxygen species produced during host defense response|evasion or tolerance by symbiont of host-produced reactive oxygen species|evasion or tolerance by symbiont of reactive oxygen species produced by other organism involved in symbiotic interaction|evasion or tolerance of defense-related host metabolic burst|evasion or tolerance of defense-related host oxidative burst|evasion or tolerance of defense-related host respiratory burst|evasion or tolerance of host-produced AOS|evasion or tolerance of host-produced ROIs|evasion or tolerance of host-produced ROS|evasion or tolerance of host-produced active oxygen species|evasion or tolerance of host-produced reactive oxygen intermediates|evasion or tolerance of reactive oxygen species produced by host|modulation by organism of defense-related host AOS production|modulation by organism of defense-related host ROI production|modulation by organism of defense-related host ROS production|modulation by organism of defense-related host active oxygen species production|modulation by organism of defense-related host metabolic burst|modulation by organism of defense-related host oxidative burst|modulation by organism of defense-related host reactive oxidative species production|modulation by organism of defense-related host reactive oxygen intermediate production|modulation by organism of defense-related host respiratory burst|modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|modulation by symbiont of defense-related host reactive oxygen species production|response to defense-related host reactive oxygen species production|response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052164 GO:0052163 biolink:BiologicalProcess obsolete symbiont defense to host-produced nitric oxide OBSOLETE. Any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json defense response to host innate immune response nitric oxide production|evasion or tolerance by organism of host NO|evasion or tolerance by organism of host nitric oxide|evasion or tolerance by organism of host-produced NO|evasion or tolerance by organism of host-produced nitric oxide|evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction|evasion or tolerance by symbiont of host-produced nitric oxide|evasion or tolerance of NO produced by host in response to organism|evasion or tolerance of nitric oxide produced by host in response to organism|modulation by organism of defense-related host NO production|modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction|modulation by symbiont of defense-related host nitric oxide production|response to defense-related host nitric oxide production|response to defense-related nitric oxide production by other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052163 GO:0052162 biolink:BiologicalProcess modulation by symbiont of defense-related host calcium ion flux Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|modulation by organism of defense-related host Ca2+ flux http://purl.obolibrary.org/obo/GO_0052162 GO:0052161 biolink:BiologicalProcess obsolete modulation by symbiont of defense-related host cell wall thickening OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction|modulation by organism of host defensive cell wall thickening True http://purl.obolibrary.org/obo/GO_0052161 GO:0052168 biolink:BiologicalProcess modulation by symbiont of defense-related host calcium-dependent protein kinase pathway Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction|modulation by organism of defense-related host CDPK pathway http://purl.obolibrary.org/obo/GO_0052168 GO:0052167 biolink:BiologicalProcess perturbation of host innate immune response A process in which an organism effects a change that affects the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of innate immune response in other organism involved in symbiotic interaction|modulation by symbiont of host innate immunity|modulation of host innate immune response http://purl.obolibrary.org/obo/GO_0052167 GO:0052166 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052166 GO:0052165 biolink:BiologicalProcess symbiont defense to host-produced phytoalexin Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json evasion or tolerance by symbiont of host-produced phytoalexins|evasion or tolerance of phytoalexins|evasion or tolerance of phytoalexins produced by host in response to organism|host phytoalexin detoxification|modulation by organism of phytoalexin production in other organism involved in symbiotic interaction|modulation by symbiont of host phytoalexin production|phytoalexin detoxification|response to host phytoalexin production|response to phytoalexin production by other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052165 GO:0052171 biolink:BiologicalProcess obsolete growth or development during symbiotic interaction OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. go.json growth or development during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052171 GO:0052170 biolink:BiologicalProcess suppression of host innate immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host innate immunity|down-regulation by symbiont of host innate immunity|downregulation by symbiont of host innate immunity|inhibition by symbiont of host innate immunity|negative regulation by symbiont of host innate immune response|negative regulation by symbiont of host innate immunity|negative regulation of host innate immune response|negative regulation of innate immune response in other organism|suppression by symbiont of host innate immune response http://purl.obolibrary.org/obo/GO_0052170 GO:0052175 biolink:BiologicalProcess obsolete metabolism by symbiont of host carbohydrate OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052175 GO:0052174 biolink:BiologicalProcess obsolete metabolism by symbiont of host macromolecule OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052174 GO:0052173 biolink:BiologicalProcess response to defenses of other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism. go.json response to defenses of other organism during symbiotic interaction|response to defenses of other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052173 GO:0052172 biolink:BiologicalProcess obsolete metabolism by symbiont of host cell wall cellulose OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052172 GO:0052179 biolink:BiologicalProcess obsolete metabolism by symbiont of host cell wall pectin OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052179 GO:0052178 biolink:BiologicalProcess obsolete metabolism by symbiont of host cell wall chitin OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052178 GO:0052177 biolink:BiologicalProcess obsolete metabolism by symbiont of host xylan OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052177 GO:0052176 biolink:BiologicalProcess obsolete metabolism by symbiont of host glucan OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052176 GO:0052182 biolink:BiologicalProcess obsolete modification by host of symbiont morphology or physiology via secreted substance OBSOLETE. The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052182 GO:0052181 biolink:BiologicalProcess obsolete modulation by host of symbiont defense response OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052181 GO:0052180 biolink:BiologicalProcess obsolete negative regulation of peptidase activity in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction. go.json down regulation of protease activity in other organism during symbiotic interaction|down-regulation of protease activity in other organism during symbiotic interaction|downregulation of protease activity in other organism during symbiotic interaction|inhibition of protease activity in other organism during symbiotic interaction|negative regulation of protease activity in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052180 GO:0052186 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052186 GO:0052185 biolink:BiologicalProcess obsolete modification of structure of other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction. go.json modification of structure of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052185 GO:0052184 biolink:BiologicalProcess obsolete modulation by organism of symbiont hormone or growth regulator levels OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont hormone or growth regulator levels True http://purl.obolibrary.org/obo/GO_0052184 GO:0052183 biolink:BiologicalProcess obsolete disruption of symbiont cellular component OBSOLETE. The process in which a host organism destabilizes a cellular component of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json degradation of symbiont cellular component by organism|disassembly by host of symbiont cellular component|disruption by host of symbiont cellular component|disruption by host of symbiont structure|modification by host of symbiont cellular component|modification by host of symbiont structure|perturbation of symbiont cellular component True http://purl.obolibrary.org/obo/GO_0052183 GO:0052189 biolink:BiologicalProcess obsolete modulation by symbiont of defense-related host cell wall callose deposition OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction|modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction|modulation by symbiont of defense-related host callose deposition True http://purl.obolibrary.org/obo/GO_0052189 GO:0052188 biolink:BiologicalProcess obsolete modification of cellular component in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction. go.json modification of cellular component in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052188 GO:0052187 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052187 GO:0052193 biolink:BiologicalProcess obsolete movement in symbiont environment OBSOLETE. The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052193 GO:0052192 biolink:BiologicalProcess obsolete movement in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json locomotion in environment of other organism during symbiotic interaction|movement in environment of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052192 GO:0052191 biolink:BiologicalProcess obsolete positive regulation by symbiont of host phagocytosis OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host phagocytosis|stimulation by symbiont of host phagocytosis|up regulation by symbiont of host phagocytosis|up-regulation by symbiont of host phagocytosis|upregulation by symbiont of host phagocytosis True http://purl.obolibrary.org/obo/GO_0052191 GO:0052190 biolink:BiologicalProcess obsolete modulation by symbiont of host phagocytosis OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052190 GO:0052197 biolink:BiologicalProcess obsolete positive regulation by host of symbiont defense response OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of symbiont defense response|stimulation by host of symbiont defense response|up regulation by host of symbiont defense response|up-regulation by host of symbiont defense response|upregulation by host of symbiont defense response True http://purl.obolibrary.org/obo/GO_0052197 GO:0052196 biolink:BiologicalProcess obsolete negative regulation by host of symbiont defense response OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json down regulation by host of symbiont defense response|down-regulation by host of symbiont defense response|downregulation by host of symbiont defense response|inhibition by host of symbiont defense response True http://purl.obolibrary.org/obo/GO_0052196 GO:0052195 biolink:BiologicalProcess obsolete movement on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction. go.json movement on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052195 GO:0052194 biolink:BiologicalProcess obsolete movement on or near symbiont OBSOLETE. The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052194 GO:0052199 biolink:BiologicalProcess obsolete negative regulation of catalytic activity in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction. go.json down regulation of enzyme activity in other organism during symbiotic interaction|down-regulation of enzyme activity in other organism during symbiotic interaction|downregulation of enzyme activity in other organism during symbiotic interaction|inhibition of enzyme activity in other organism|inhibition of enzyme activity in other organism during symbiotic interaction|negative regulation of enzyme activity in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052199 GO:0052198 biolink:BiologicalProcess obsolete modulation of peptidase activity in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of protease activity in other organism during symbiotic interaction|modulation of protease activity in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052198 GO:0003197 biolink:BiologicalProcess endocardial cushion development The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. go.json http://purl.obolibrary.org/obo/GO_0003197 GO:0003196 biolink:BiologicalProcess ventriculo bulbo valve formation The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003196 GO:0003199 biolink:BiologicalProcess endocardial cushion to mesenchymal transition involved in heart valve formation A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve. go.json endocardial cushion to mesenchymal transition involved in valve formation http://purl.obolibrary.org/obo/GO_0003199 GO:0003198 biolink:BiologicalProcess epithelial to mesenchymal transition involved in endocardial cushion formation A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. go.json http://purl.obolibrary.org/obo/GO_0003198 GO:0003193 biolink:BiologicalProcess pulmonary valve formation The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003193 GO:0003192 biolink:BiologicalProcess mitral valve formation The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003192 GO:0003195 biolink:BiologicalProcess tricuspid valve formation The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003195 GO:0003194 biolink:BiologicalProcess sinoatrial valve formation The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json SA valve formation http://purl.obolibrary.org/obo/GO_0003194 GO:0003179 biolink:BiologicalProcess heart valve morphogenesis The process in which the structure of a heart valve is generated and organized. go.json heart valve remodeling|heart valve remodelling http://purl.obolibrary.org/obo/GO_0003179 GO:0003178 biolink:BiologicalProcess coronary sinus valve development The progression of the valve of the coronary sinus over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003178 GO:0003175 biolink:BiologicalProcess tricuspid valve development The progression of the tricuspid valve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003175 GO:0003174 biolink:BiologicalProcess mitral valve development The progression of the mitral valve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003174 GO:0003177 biolink:BiologicalProcess pulmonary valve development The progression of the pulmonary valve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003177 GO:0003176 biolink:BiologicalProcess aortic valve development The progression of the aortic valve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003176 GO:0003171 biolink:BiologicalProcess atrioventricular valve development The progression of the atrioventricular valve over time, from its formation to the mature structure. go.json AV valve development http://purl.obolibrary.org/obo/GO_0003171 GO:0003170 biolink:BiologicalProcess heart valve development The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. go.json cardiac valve development http://purl.obolibrary.org/obo/GO_0003170 GO:0003173 biolink:BiologicalProcess ventriculo bulbo valve development The progression of the ventriculo bulbo valve over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003173 GO:0003172 biolink:BiologicalProcess sinoatrial valve development The progression of the sinoatrial valve over time, from its formation to the mature structure. go.json SA valve development http://purl.obolibrary.org/obo/GO_0003172 GO:0003180 biolink:BiologicalProcess aortic valve morphogenesis The process in which the structure of the aortic valve is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003180 GO:0003189 biolink:BiologicalProcess aortic valve formation The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003189 GO:0003186 biolink:BiologicalProcess tricuspid valve morphogenesis The process in which the structure of the tricuspid valve is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003186 GO:0003185 biolink:BiologicalProcess sinoatrial valve morphogenesis The process in which the structure of the sinoatrial valve is generated and organized. go.json SA valve morphogenesis http://purl.obolibrary.org/obo/GO_0003185 GO:0003188 biolink:BiologicalProcess heart valve formation The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003188 GO:0003187 biolink:BiologicalProcess ventriculo bulbo valve morphogenesis The process in which the structure of the ventriculo bulbo valve is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003187 GO:0003182 biolink:BiologicalProcess coronary sinus valve morphogenesis The process in which the structure of the coronary sinus valve is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003182 GO:0003181 biolink:BiologicalProcess atrioventricular valve morphogenesis The process in which the structure of the atrioventricular valve is generated and organized. go.json AV valve morphogenesis http://purl.obolibrary.org/obo/GO_0003181 GO:0003184 biolink:BiologicalProcess pulmonary valve morphogenesis The process in which the structure of the pulmonary valve is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003184 GO:0003183 biolink:BiologicalProcess mitral valve morphogenesis The process in which the structure of the mitral valve is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003183 GO:0003191 biolink:BiologicalProcess coronary sinus valve formation The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json http://purl.obolibrary.org/obo/GO_0003191 GO:0003190 biolink:BiologicalProcess atrioventricular valve formation The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. go.json AV valve formation http://purl.obolibrary.org/obo/GO_0003190 GO:0042761 biolink:BiologicalProcess very long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons. MetaCyc:PWY-5080 go.json very-long-chain fatty acid anabolism|very-long-chain fatty acid biosynthesis|very-long-chain fatty acid biosynthetic process|very-long-chain fatty acid formation|very-long-chain fatty acid synthesis http://purl.obolibrary.org/obo/GO_0042761 GO:0042760 biolink:BiologicalProcess very long-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons. go.json very-long-chain fatty acid breakdown|very-long-chain fatty acid catabolic process|very-long-chain fatty acid catabolism|very-long-chain fatty acid degradation http://purl.obolibrary.org/obo/GO_0042760 GO:0042763 biolink:CellularComponent intracellular immature spore A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants. go.json forespore http://purl.obolibrary.org/obo/GO_0042763 GO:0042762 biolink:BiologicalProcess regulation of sulfur metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. go.json regulation of sulfur metabolism|regulation of sulphur metabolic process|regulation of sulphur metabolism http://purl.obolibrary.org/obo/GO_0042762 GO:0042769 biolink:BiologicalProcess obsolete DNA damage response, detection of DNA damage OBSOLETE. The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. go.json DNA damage response, perception of DNA damage|detection of DNA damage during DNA damage response True http://purl.obolibrary.org/obo/GO_0042769 GO:0042768 biolink:MolecularActivity ecdysteroid 2-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 2. go.json http://purl.obolibrary.org/obo/GO_0042768 GO:0042765 biolink:CellularComponent GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor. go.json GPIT complex http://purl.obolibrary.org/obo/GO_0042765 GO:0042764 biolink:CellularComponent ascospore-type prospore An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi. go.json http://purl.obolibrary.org/obo/GO_0042764 GO:0042767 biolink:MolecularActivity ecdysteroid 22-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 22. go.json http://purl.obolibrary.org/obo/GO_0042767 GO:0042766 biolink:BiologicalProcess obsolete nucleosome mobilization OBSOLETE. The movement of nucleosomes along a DNA fragment. go.json nucleosome sliding True http://purl.obolibrary.org/obo/GO_0042766 GO:0042772 biolink:BiologicalProcess DNA damage response, signal transduction resulting in transcription A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. go.json http://purl.obolibrary.org/obo/GO_0042772 GO:0042771 biolink:BiologicalProcess intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. go.json DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis http://purl.obolibrary.org/obo/GO_0042771 GO:0042774 biolink:BiologicalProcess plasma membrane ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0042774 GO:0042773 biolink:BiologicalProcess ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. go.json http://purl.obolibrary.org/obo/GO_0042773 GO:0042770 biolink:BiologicalProcess signal transduction in response to DNA damage A cascade of processes induced by the detection of DNA damage within a cell. go.json DNA damage induced protein phosphorylation|DNA damage response, signal transduction|response to DNA damage stimulus by intracellular signaling cascade http://purl.obolibrary.org/obo/GO_0042770 GO:0042779 biolink:BiologicalProcess obsolete tRNA 3'-trailer cleavage OBSOLETE. Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. go.json removal of tRNA 3'-trailer sequence|tRNA 3'-end cleavage True http://purl.obolibrary.org/obo/GO_0042779 GO:0042776 biolink:BiologicalProcess proton motive force-driven mitochondrial ATP synthesis The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. go.json mitochondrial ATP synthesis coupled proton transport|mitochondrial proton transport http://purl.obolibrary.org/obo/GO_0042776 GO:0042775 biolink:BiologicalProcess mitochondrial ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. go.json mitochondrial electron transport|organelle ATP synthesis coupled electron transport http://purl.obolibrary.org/obo/GO_0042775 GO:0042778 biolink:BiologicalProcess tRNA end turnover The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA. go.json http://purl.obolibrary.org/obo/GO_0042778 GO:0042777 biolink:BiologicalProcess proton motive force-driven plasma membrane ATP synthesis The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. go.json ATP synthesis coupled proton transport|plasma membrane ATP synthesis coupled proton transport http://purl.obolibrary.org/obo/GO_0042777 GO:0052106 biolink:BiologicalProcess obsolete quorum sensing involved in interaction with host OBSOLETE. The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json quorum sensing during interaction with host True http://purl.obolibrary.org/obo/GO_0052106 GO:0052105 biolink:BiologicalProcess obsolete induction by symbiont of defense-related host cell wall thickening OBSOLETE. The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related host cell wall thickening|activation by organism of host defensive cell wall thickening|activation by symbiont of defense-related host cell wall thickening|induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction|induction by organism of host defensive cell wall thickening|positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction|positive regulation by organism of host defensive cell wall thickening|positive regulation by symbiont of defense-related host cell wall thickening|stimulation by symbiont of defense-related host cell wall thickening|up regulation by symbiont of defense-related host cell wall thickening|up-regulation by symbiont of defense-related host cell wall thickening|upregulation by symbiont of defense-related host cell wall thickening True http://purl.obolibrary.org/obo/GO_0052105 GO:0052104 biolink:BiologicalProcess induction by symbiont of host systemic acquired resistance Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of SAR in host|activation by organism of systemic acquired resistance in host|induction by organism of SAR in host|induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction|induction by symbiont of systemic acquired resistance in host|positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction|positive regulation by symbiont of host systemic acquired resistance|positive regulation by symbiont of systemic acquired resistance in host|stimulation by symbiont of systemic acquired resistance in host|up regulation by symbiont of systemic acquired resistance in host|up-regulation by symbiont of systemic acquired resistance in host|upregulation by symbiont of systemic acquired resistance in host http://purl.obolibrary.org/obo/GO_0052104 GO:0052103 biolink:BiologicalProcess induction of host induced systemic resistance Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of ISR in host|activation by organism of induced systemic resistance in host|activation by symbiont of induced systemic resistance in host|induction by organism of ISR in host|induction by organism of induced systemic resistance in other organism involved in symbiotic interaction|induction by symbiont of host induced systemic resistance|induction by symbiont of induced systemic resistance in host|positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction|positive regulation by symbiont of host induced systemic resistance|positive regulation by symbiont of induced systemic resistance in host|stimulation by symbiont of induced systemic resistance in host|up regulation by symbiont of induced systemic resistance in host|up-regulation by symbiont of induced systemic resistance in host|upregulation by symbiont of induced systemic resistance in host http://purl.obolibrary.org/obo/GO_0052103 GO:0052109 biolink:BiologicalProcess obsolete induction by symbiont of defense-related host cell wall callose deposition OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of defense-related host cell wall callose deposition|positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction|positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction|positive regulation by symbiont of defense-related host callose deposition|positive regulation by symbiont of defense-related host cell wall callose deposition|stimulation by symbiont of defense-related host cell wall callose deposition|up regulation by symbiont of defense-related host cell wall callose deposition|up-regulation by symbiont of defense-related host cell wall callose deposition|upregulation by symbiont of defense-related host cell wall callose deposition True http://purl.obolibrary.org/obo/GO_0052109 GO:0052108 biolink:BiologicalProcess obsolete growth or development of symbiont during interaction with host OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json growth or development of organism during interaction with host|growth or development of organism in response to host|growth or development of symbiont during interaction with host True http://purl.obolibrary.org/obo/GO_0052108 GO:0052107 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052107 GO:0042783 biolink:BiologicalProcess evasion of host immune response A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json active evasion of host immune response|active evasion of immune response of other organism involved in symbiotic interaction|active immune evasion|evasion by virus of host immune response|evasion or tolerance of host immune response|immune evasion|mitigation by virus of host immune response|mitigation of host immune response|mitigation of host immune response by virus|passive evasion of host immune response|passive evasion of immune response of other organism involved in symbiotic interaction|passive immune evasion|suppression by virus of host immune response http://purl.obolibrary.org/obo/GO_0042783 GO:0042782 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042782 GO:0042785 biolink:BiologicalProcess evasion of host immune response via modulation of host cytokine network Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json active evasion of host immune response via regulation of host cytokine network|active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction|active immune evasion via modulation of host cytokine network|active immune evasion via regulation of host cytokine network|evasion of host immune response via regulation of host cytokine network http://purl.obolibrary.org/obo/GO_0042785 GO:0042784 biolink:BiologicalProcess evasion of host immune response via modulation of host complement system Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json active evasion of host immune response via regulation of host complement system|active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction|active immune evasion via modulation of host complement system|active immune evasion via regulation of host complement system|evasion of host immune response via regulation of host complement system http://purl.obolibrary.org/obo/GO_0042784 GO:0042781 biolink:MolecularActivity 3'-tRNA processing endoribonuclease activity Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. EC:3.1.26.11|MetaCyc:3.1.26.11-RXN go.json 3 tRNase activity|3' tRNA processing endoribonuclease activity|3' tRNase activity|RNase Z activity|ribonuclease Z activity|tRNA 3 endonuclease activity|tRNA 3' endonuclease activity|tRNAse Z http://purl.obolibrary.org/obo/GO_0042781 GO:0042780 biolink:BiologicalProcess tRNA 3'-end processing The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. go.json tRNA 3' processing http://purl.obolibrary.org/obo/GO_0042780 GO:0042787 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042787 GO:0042786 biolink:BiologicalProcess evasion of host immune response via modulation of host antigen processing and presentation Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json active evasion of host immune response via regulation of host antigen processing and presentation|active evasion of host immune response via regulation of host antigen processing and presentation pathway|active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction|active immune evasion via modulation of antigen processing and presentation|active immune evasion via modulation of antigen processing/presentation|active immune evasion via regulation of antigen processing and presentation|evasion of host immune response via regulation of host antigen processing and presentation http://purl.obolibrary.org/obo/GO_0042786 GO:0042789 biolink:BiologicalProcess mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. go.json mRNA transcription from Pol II promoter|mRNA transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0042789 GO:0042788 biolink:CellularComponent polysomal ribosome A ribosome bound to mRNA that forms part of a polysome. go.json active ribosome http://purl.obolibrary.org/obo/GO_0042788 GO:0052102 biolink:BiologicalProcess positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of defense-related host calcium-dependent protein kinase pathway|positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction|positive regulation of defense-related host CDPK pathway by organism|stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway|up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway|up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway|upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway http://purl.obolibrary.org/obo/GO_0052102 GO:0052101 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052101 GO:0052100 biolink:BiologicalProcess obsolete intraspecies quorum sensing OBSOLETE. The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules. go.json True http://purl.obolibrary.org/obo/GO_0052100 GO:0052117 biolink:BiologicalProcess obsolete aerotaxis in host environment OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json aerotaxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052117 GO:0052116 biolink:BiologicalProcess obsolete chemotaxis in host environment OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json chemotaxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052116 GO:0052115 biolink:BiologicalProcess obsolete energy taxis in host environment OBSOLETE. The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json energy taxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052115 GO:0052114 biolink:BiologicalProcess obsolete adaptation to host pH environment OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adaptation to host pH environment|pH tolerance to host environment True http://purl.obolibrary.org/obo/GO_0052114 GO:0052119 biolink:BiologicalProcess obsolete negative energy taxis in host environment OBSOLETE. The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative energy taxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052119 GO:0052118 biolink:BiologicalProcess obsolete positive energy taxis in host environment OBSOLETE. The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive energy taxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052118 GO:0042794 biolink:BiologicalProcess plastid rRNA transcription The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase. go.json rRNA transcription from plastid promoter http://purl.obolibrary.org/obo/GO_0042794 GO:0042793 biolink:BiologicalProcess plastid transcription The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase. go.json transcription from plastid promoter http://purl.obolibrary.org/obo/GO_0042793 GO:0042796 biolink:BiologicalProcess snRNA transcription by RNA polymerase III The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. go.json snRNA transcription from Pol III promoter|snRNA transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0042796 GO:0042795 biolink:BiologicalProcess snRNA transcription by RNA polymerase II The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. go.json snRNA transcription from Pol II promoter|snRNA transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0042795 GO:0042790 biolink:BiologicalProcess nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I. go.json transcription of nuclear large rRNA transcript from RNA polymerase I promoter|transcription of nuclear rRNA large Pol I transcript|transcription of nucleolar large rRNA by RNA polymerase I http://purl.obolibrary.org/obo/GO_0042790 GO:0042792 biolink:BiologicalProcess obsolete mitochondrial rRNA transcription OBSOLETE. The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template. go.json rRNA transcription from mitochondrial promoter True http://purl.obolibrary.org/obo/GO_0042792 GO:0042791 biolink:BiologicalProcess 5S class rRNA transcription by RNA polymerase III The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter. go.json 5S class rRNA transcription from RNA polymerase III type 1 promoter|5S rRNA transcription http://purl.obolibrary.org/obo/GO_0042791 GO:0042798 biolink:BiologicalProcess obsolete protein neddylation during NEDD8 class-dependent protein catabolic process OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism. go.json protein neddylation during NEDD8 class-dependent protein breakdown|protein neddylation during NEDD8 class-dependent protein catabolic process|protein neddylation during NEDD8 class-dependent protein catabolism|protein neddylation during NEDD8 class-dependent protein degradation|protein neddylation during RUB1-dependent protein catabolic process|protein neddylation during RUB1-dependent protein catabolism True http://purl.obolibrary.org/obo/GO_0042798 GO:0042797 biolink:BiologicalProcess tRNA transcription by RNA polymerase III The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter. go.json tRNA transcription from Pol III promoter|tRNA transcription from RNA polymerase III promoter http://purl.obolibrary.org/obo/GO_0042797 GO:0042799 biolink:MolecularActivity histone H4K20 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein. Reactome:R-HSA-2301205|Reactome:R-HSA-5682965 go.json histone H4 lysine 20-specific methyltransferase activity|histone H4K20 methylase activity|histone H4K20 methylation|histone lysine N-methyltransferase activity (H4-K20 specific)|histone methylase activity (H4-K20 specific)|histone methyltransferase activity (H4-K20 specific)|histone-H4K20 methyltransferase activity http://purl.obolibrary.org/obo/GO_0042799 GO:0052113 biolink:BiologicalProcess obsolete adaptation to host osmotic environment OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json adaptation to host osmotic environment|osmotic tolerance to host environment True http://purl.obolibrary.org/obo/GO_0052113 GO:0052112 biolink:BiologicalProcess symbiont-mediated occlusion of host xylem The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json occlusion by symbiont of host xylem http://purl.obolibrary.org/obo/GO_0052112 GO:0052111 biolink:BiologicalProcess symbiont-mediated disruption of host anatomical structure The process in which an organism effects a change that impairs the structure or function of an anatomical structure of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json disruption by symbiont of host anatomical structure|modification by symbiont of host anatomical structure|modification by symbiont of host structure http://purl.obolibrary.org/obo/GO_0052111 GO:0052110 biolink:BiologicalProcess obsolete occlusion by symbiont of host vascular system OBSOLETE. The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052110 GO:0052128 biolink:BiologicalProcess positive energy taxis The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. go.json http://purl.obolibrary.org/obo/GO_0052128 GO:0052127 biolink:BiologicalProcess obsolete movement on or near host OBSOLETE. The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052127 GO:0052126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052126 GO:0052125 biolink:BiologicalProcess obsolete energy taxis on or near host OBSOLETE. The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052125 GO:0052129 biolink:BiologicalProcess negative energy taxis The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. go.json http://purl.obolibrary.org/obo/GO_0052129 GO:0052120 biolink:BiologicalProcess obsolete positive aerotaxis in host environment OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive aerotaxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052120 GO:0052124 biolink:BiologicalProcess obsolete energy taxis within host OBSOLETE. The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052124 GO:0052123 biolink:BiologicalProcess obsolete negative chemotaxis in host environment OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative chemotaxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052123 GO:0052122 biolink:BiologicalProcess obsolete negative aerotaxis in host environment OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative aerotaxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052122 GO:0052121 biolink:BiologicalProcess obsolete positive chemotaxis in host environment OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive chemotaxis in response to host environment True http://purl.obolibrary.org/obo/GO_0052121 GO:0052139 biolink:BiologicalProcess obsolete negative chemotaxis in host OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative chemotaxis within host True http://purl.obolibrary.org/obo/GO_0052139 GO:0052138 biolink:BiologicalProcess obsolete aerotaxis on or near host OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052138 GO:0052137 biolink:BiologicalProcess obsolete aerotaxis in host OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json aerotaxis within host True http://purl.obolibrary.org/obo/GO_0052137 GO:0052136 biolink:BiologicalProcess obsolete negative chemotaxis on or near host OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052136 GO:0052131 biolink:BiologicalProcess positive aerotaxis The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen. go.json http://purl.obolibrary.org/obo/GO_0052131 GO:0052130 biolink:BiologicalProcess negative aerotaxis The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen. go.json http://purl.obolibrary.org/obo/GO_0052130 GO:0052135 biolink:BiologicalProcess obsolete negative aerotaxis in host OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative aerotaxis within host True http://purl.obolibrary.org/obo/GO_0052135 GO:0052134 biolink:BiologicalProcess obsolete negative aerotaxis on or near host OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052134 GO:0052133 biolink:BiologicalProcess obsolete positive aerotaxis in host OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive aerotaxis within host True http://purl.obolibrary.org/obo/GO_0052133 GO:0052132 biolink:BiologicalProcess obsolete positive aerotaxis on or near host OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052132 GO:0052149 biolink:BiologicalProcess obsolete modulation by symbiont of host peptidase activity OBSOLETE. The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host protease activity True http://purl.obolibrary.org/obo/GO_0052149 GO:0052148 biolink:BiologicalProcess modulation by symbiont of host catalytic activity The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by symbiont of host enzyme activity|modulation of catalytic activity of host by symbiont|regulation by symbiont of host catalytic activity|regulation of catalytic activity of host by symbiont|regulation of host catalytic activity by symbiont http://purl.obolibrary.org/obo/GO_0052148 GO:0052147 biolink:BiologicalProcess obsolete positive energy taxis in host OBSOLETE. The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive energy taxis within host True http://purl.obolibrary.org/obo/GO_0052147 GO:0052142 biolink:BiologicalProcess obsolete chemotaxis within host OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052142 GO:0052141 biolink:BiologicalProcess obsolete positive chemotaxis on or near host OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052141 GO:0052140 biolink:BiologicalProcess obsolete positive chemotaxis in host OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive chemotaxis within host True http://purl.obolibrary.org/obo/GO_0052140 GO:0052146 biolink:BiologicalProcess obsolete positive energy taxis on or near host OBSOLETE. The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052146 GO:0052145 biolink:BiologicalProcess obsolete negative energy taxis on or near host OBSOLETE. The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052145 GO:0052144 biolink:BiologicalProcess obsolete negative energy taxis in host OBSOLETE. The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative energy taxis within host True http://purl.obolibrary.org/obo/GO_0052144 GO:0052143 biolink:BiologicalProcess obsolete chemotaxis on or near host involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json chemotaxis on or near host during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052143 GO:0052159 biolink:BiologicalProcess perturbation of host induced systemic resistance A process in which an organism effects a change that affects the induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction|modulation by symbiont of induced systemic resistance in host http://purl.obolibrary.org/obo/GO_0052159 GO:0052158 biolink:BiologicalProcess modulation by symbiont of host resistance gene-dependent defense response Any process in which a symbiont modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense response in host by specific elicitors|modulation by organism of host gene-for-gene resistance|modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont|modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052158 GO:0052153 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052153 GO:0052152 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052152 GO:0052151 biolink:BiologicalProcess symbiont-mediated activation of host apoptosis A process in which a symbiont gene product activates host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json GO:0052151|activation by organism of host apoptosis|activation by organism of host apoptotic programmed cell death|activation by symbiont of host apoptosis|induction by organism of host apoptotic programmed cell death|induction by symbiont of host apoptosis|positive regulation by organism of host apoptotic programmed cell death|positive regulation by symbiont of host apoptosis|positive regulation by symbiont of host apoptotic process|stimulation by symbiont of host apoptosis|up regulation by organism of host apoptotic programmed cell death|up regulation by symbiont of host apoptosis|up-regulation by organism of host apoptotic programmed cell death|up-regulation by symbiont of host apoptosis|upregulation by organism of host apoptotic programmed cell death|upregulation by symbiont of host apoptosis http://purl.obolibrary.org/obo/GO_0052151 GO:0052150 biolink:BiologicalProcess symbiont-mediated perturbation of host apoptosis A process in which a symbiont gene product affects host apoptosis, leading to a change in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of host apoptotic programmed cell death|modulation by symbiont of host apoptosis|modulation by symbiont of host apoptotic process http://purl.obolibrary.org/obo/GO_0052150 GO:0052157 biolink:BiologicalProcess obsolete modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response OBSOLETE. Any process that involves recognition of a microbe-associated molecular pattern, and by which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction|modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity|modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity True http://purl.obolibrary.org/obo/GO_0052157 GO:0052156 biolink:BiologicalProcess perturbation of host T-cell mediated immune response A process in which an organism effects a change that affects the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction|modulation by symbiont of host T-cell mediated immune response http://purl.obolibrary.org/obo/GO_0052156 GO:0052155 biolink:BiologicalProcess perturbation of host cell-mediated immune response A process in which an organism effects a change that affects cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction|modulation by organism of host cell-based immune response|modulation by symbiont of host cell-mediated immune response http://purl.obolibrary.org/obo/GO_0052155 GO:0052154 biolink:BiologicalProcess perturbation of host B-cell mediated immune response A process in which an organism effects a change that affects the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction|modulation by symbiont of host B-cell mediated immune response|regulation by organism of host B-cell mediated immune response http://purl.obolibrary.org/obo/GO_0052154 GO:0042703 biolink:BiologicalProcess menstruation The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus. Wikipedia:Menstruation go.json http://purl.obolibrary.org/obo/GO_0042703 gocheck_do_not_annotate GO:0042702 biolink:BiologicalProcess uterine wall growth The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels. go.json http://purl.obolibrary.org/obo/GO_0042702 GO:0042705 biolink:BiologicalProcess ocellus photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus. go.json http://purl.obolibrary.org/obo/GO_0042705 GO:0042704 biolink:BiologicalProcess uterine wall breakdown The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels. go.json http://purl.obolibrary.org/obo/GO_0042704 GO:0042701 biolink:BiologicalProcess progesterone secretion The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta. go.json http://purl.obolibrary.org/obo/GO_0042701 GO:0042700 biolink:BiologicalProcess luteinizing hormone signaling pathway A G protein-coupled receptor signaling pathway initiated by luteinizing hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json luteinizing hormone signalling pathway http://purl.obolibrary.org/obo/GO_0042700 GO:0042707 biolink:BiologicalProcess ocellus photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. go.json http://purl.obolibrary.org/obo/GO_0042707 GO:0042706 biolink:BiologicalProcess eye photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. go.json http://purl.obolibrary.org/obo/GO_0042706 GO:0042709 biolink:CellularComponent succinate-CoA ligase complex A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. go.json http://purl.obolibrary.org/obo/GO_0042709 GO:0042708 biolink:MolecularActivity obsolete elastase activity OBSOLETE. Catalysis of the hydrolysis of elastin. go.json elastase activity True http://purl.obolibrary.org/obo/GO_0042708 GO:0042714 biolink:BiologicalProcess dosage compensation complex assembly The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes. go.json http://purl.obolibrary.org/obo/GO_0042714 GO:0042713 biolink:BiologicalProcess sperm ejaculation The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. go.json http://purl.obolibrary.org/obo/GO_0042713 GO:0042716 biolink:CellularComponent plasma membrane-derived chromatophore A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria. go.json chromatophore vesicle http://purl.obolibrary.org/obo/GO_0042716 GO:0042715 biolink:BiologicalProcess obsolete dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome OBSOLETE. The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans. go.json dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome True http://purl.obolibrary.org/obo/GO_0042715 GO:0042710 biolink:BiologicalProcess biofilm formation A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. go.json http://purl.obolibrary.org/obo/GO_0042710 gocheck_do_not_annotate|gocheck_do_not_manually_annotate|goslim_candida|goslim_pir GO:0042712 biolink:BiologicalProcess paternal behavior Male behaviors associated with the care and rearing offspring. go.json paternal behaviour http://purl.obolibrary.org/obo/GO_0042712 GO:0042711 biolink:BiologicalProcess maternal behavior Female behaviors associated with the care and rearing of offspring. go.json maternal behaviour http://purl.obolibrary.org/obo/GO_0042711 GO:0042718 biolink:CellularComponent yolk granule Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed. go.json http://purl.obolibrary.org/obo/GO_0042718 GO:0042717 biolink:CellularComponent plasma membrane-derived chromatophore membrane The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles. go.json http://purl.obolibrary.org/obo/GO_0042717 GO:0042719 biolink:CellularComponent mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. go.json Tim9-Tim10 complex http://purl.obolibrary.org/obo/GO_0042719 GO:0042725 biolink:BiologicalProcess thiamine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it. go.json thiamin and derivative catabolic process|thiamin and derivative catabolism|thiamin-containing compound catabolic process|thiamine and derivative catabolic process|thiamine and derivative catabolism|thiamine-containing compound breakdown|thiamine-containing compound catabolism|thiamine-containing compound degradation|vitamin B1 and derivative catabolic process|vitamin B1 and derivative catabolism http://purl.obolibrary.org/obo/GO_0042725 GO:0042724 biolink:BiologicalProcess thiamine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds. go.json thiamin and derivative biosynthesis|thiamin and derivative biosynthetic process|thiamin-containing compound biosynthetic process|thiamine and derivative biosynthesis|thiamine and derivative biosynthetic process|thiamine-containing compound anabolism|thiamine-containing compound biosynthesis|thiamine-containing compound formation|thiamine-containing compound synthesis|vitamin B1 and derivative biosynthesis|vitamin B1 and derivative biosynthetic process http://purl.obolibrary.org/obo/GO_0042724 GO:0042727 biolink:BiologicalProcess flavin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. go.json flavin-containing compound anabolism|flavin-containing compound biosynthesis|flavin-containing compound formation|flavin-containing compound synthesis|riboflavin and derivative biosynthesis|riboflavin and derivative biosynthetic process|vitamin B2 and derivative biosynthesis|vitamin B2 and derivative biosynthetic process http://purl.obolibrary.org/obo/GO_0042727 GO:0042726 biolink:BiologicalProcess flavin-containing compound metabolic process The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. go.json flavin-containing compound metabolism|riboflavin and derivative metabolic process|riboflavin and derivative metabolism|vitamin B2 and derivative metabolic process|vitamin B2 and derivative metabolism http://purl.obolibrary.org/obo/GO_0042726 GO:0042721 biolink:CellularComponent TIM22 mitochondrial import inner membrane insertion complex A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12. go.json Tim22 complex|mitochondrial inner membrane protein insertion complex|mitochondrial protein translocase complex http://purl.obolibrary.org/obo/GO_0042721 GO:0042720 biolink:CellularComponent mitochondrial inner membrane peptidase complex Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space. go.json IMP|mitochondrion inner membrane peptidase complex http://purl.obolibrary.org/obo/GO_0042720 GO:0042723 biolink:BiologicalProcess thiamine-containing compound metabolic process The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it. go.json thiamin and derivative metabolic process|thiamin and derivative metabolism|thiamin-containing compound metabolic process|thiamine and derivative metabolic process|thiamine and derivative metabolism|thiamine-containing compound metabolism|vitamin B1 and derivative metabolic process|vitamin B1 and derivative metabolism http://purl.obolibrary.org/obo/GO_0042723 GO:0042722 biolink:BiologicalProcess alpha-beta T cell activation by superantigen The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region. go.json alpha-beta T lymphocyte activation by superantigen|alpha-beta T-cell activation by superantigen|alpha-beta T-lymphocyte activation by superantigen http://purl.obolibrary.org/obo/GO_0042722 GO:0042729 biolink:CellularComponent DASH complex A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. go.json DDD complex|Dam1 complex|Duo1p-Dam1p-Dad1p complex|condensed nuclear chromosome kinetochore-associated DASH complex http://purl.obolibrary.org/obo/GO_0042729 GO:0042728 biolink:BiologicalProcess flavin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. go.json flavin-containing compound catabolic process breakdown|flavin-containing compound catabolic process degradation|flavin-containing compound catabolism|riboflavin and derivative catabolic process|riboflavin and derivative catabolism|vitamin B2 and derivative catabolic process|vitamin B2 and derivative catabolism http://purl.obolibrary.org/obo/GO_0042728 GO:0042730 biolink:BiologicalProcess fibrinolysis A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. Wikipedia:Fibrinolysis go.json http://purl.obolibrary.org/obo/GO_0042730 GO:0042736 biolink:MolecularActivity NADH kinase activity Catalysis of the reaction: ATP + NADH = ADP + 2 H+ + NADPH. EC:2.7.1.86|KEGG_REACTION:R00105|MetaCyc:NADH-KINASE-RXN|RHEA:12260 go.json ATP:NADH 2'-phosphotransferase activity|DPNH kinase activity|reduced diphosphopyridine nucleotide kinase activity|reduced nicotinamide adenine dinucleotide kinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0042736 GO:0042735 biolink:CellularComponent endosperm protein body A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins. go.json https://github.com/geneontology/go-ontology/issues/24425 http://purl.obolibrary.org/obo/GO_0042735 GO:0042738 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042738 GO:0042737 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042737 GO:0042732 biolink:BiologicalProcess D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. go.json D-xylose metabolism http://purl.obolibrary.org/obo/GO_0042732 GO:0042731 biolink:MolecularActivity PH domain binding Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0042731 GO:0042734 biolink:CellularComponent presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. go.json pre-synaptic membrane|presynaptic plasma membrane http://purl.obolibrary.org/obo/GO_0042734 goslim_synapse GO:0042733 biolink:BiologicalProcess embryonic digit morphogenesis The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. go.json http://purl.obolibrary.org/obo/GO_0042733 GO:0042739 biolink:BiologicalProcess obsolete endogenous drug catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism. go.json endogenous drug breakdown|endogenous drug catabolism|endogenous drug degradation True http://purl.obolibrary.org/obo/GO_0042739 GO:0042741 biolink:BiologicalProcess endogenous antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism. go.json endogenous antibiotic breakdown|endogenous antibiotic catabolism|endogenous antibiotic degradation http://purl.obolibrary.org/obo/GO_0042741 GO:0042740 biolink:BiologicalProcess exogenous antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism. go.json exogenous antibiotic breakdown|exogenous antibiotic catabolism|exogenous antibiotic degradation http://purl.obolibrary.org/obo/GO_0042740 GO:0042747 biolink:BiologicalProcess circadian sleep/wake cycle, REM sleep A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity. go.json http://purl.obolibrary.org/obo/GO_0042747 GO:0042746 biolink:BiologicalProcess circadian sleep/wake cycle, wakefulness The part of the circadian sleep/wake cycle where the organism is not asleep. go.json http://purl.obolibrary.org/obo/GO_0042746 GO:0042749 biolink:BiologicalProcess regulation of circadian sleep/wake cycle Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. go.json http://purl.obolibrary.org/obo/GO_0042749 GO:0042748 biolink:BiologicalProcess circadian sleep/wake cycle, non-REM sleep All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. go.json http://purl.obolibrary.org/obo/GO_0042748 GO:0042743 biolink:BiologicalProcess hydrogen peroxide metabolic process The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. go.json H2O2 metabolic process|hydrogen peroxide metabolism http://purl.obolibrary.org/obo/GO_0042743 GO:0042742 biolink:BiologicalProcess defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. go.json antibacterial peptide activity|defence response to bacteria|defence response to bacterium|defense response to bacteria|defense response to bacterium, incompatible interaction|resistance response to pathogenic bacteria|resistance response to pathogenic bacterium http://purl.obolibrary.org/obo/GO_0042742 GO:0042745 biolink:BiologicalProcess circadian sleep/wake cycle The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. go.json http://purl.obolibrary.org/obo/GO_0042745 GO:0042744 biolink:BiologicalProcess hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). go.json H2O2 catabolic process|H2O2 scavenging|detoxification of H2O2|detoxification of hydrogen peroxide|hydrogen peroxide breakdown|hydrogen peroxide catabolism|hydrogen peroxide degradation|hydrogen peroxide removal|hydrogen peroxide scavenging http://purl.obolibrary.org/obo/GO_0042744 GO:0042750 biolink:BiologicalProcess hibernation Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs. Wikipedia:Hibernation go.json http://purl.obolibrary.org/obo/GO_0042750 GO:0042752 biolink:BiologicalProcess regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. go.json http://purl.obolibrary.org/obo/GO_0042752 GO:0042751 biolink:BiologicalProcess estivation Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season. Wikipedia:Estivation go.json aestivation http://purl.obolibrary.org/obo/GO_0042751 GO:0042758 biolink:BiologicalProcess long-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json long-chain fatty acid breakdown|long-chain fatty acid catabolism|long-chain fatty acid degradation http://purl.obolibrary.org/obo/GO_0042758 GO:0042757 biolink:CellularComponent giant axon Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses. go.json http://purl.obolibrary.org/obo/GO_0042757 GO:0042759 biolink:BiologicalProcess long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons. go.json long-chain fatty acid anabolism|long-chain fatty acid biosynthesis|long-chain fatty acid formation|long-chain fatty acid synthesis http://purl.obolibrary.org/obo/GO_0042759 GO:0042754 biolink:BiologicalProcess negative regulation of circadian rhythm Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. go.json down regulation of circadian rhythm|down-regulation of circadian rhythm|downregulation of circadian rhythm|inhibition of circadian rhythm http://purl.obolibrary.org/obo/GO_0042754 GO:0042753 biolink:BiologicalProcess positive regulation of circadian rhythm Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. go.json activation of circadian rhythm|stimulation of circadian rhythm|up regulation of circadian rhythm|up-regulation of circadian rhythm|upregulation of circadian rhythm http://purl.obolibrary.org/obo/GO_0042753 GO:0042756 biolink:BiologicalProcess drinking behavior The specific behavior of an organism relating to the intake of liquids, especially water. go.json drinking behaviour http://purl.obolibrary.org/obo/GO_0042756 GO:0042755 biolink:BiologicalProcess eating behavior The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. go.json eating behaviour http://purl.obolibrary.org/obo/GO_0042755 GO:0003157 biolink:BiologicalProcess endocardium development The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. go.json http://purl.obolibrary.org/obo/GO_0003157 GO:0003156 biolink:BiologicalProcess regulation of animal organ formation Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. go.json http://purl.obolibrary.org/obo/GO_0003156 GO:0003159 biolink:BiologicalProcess morphogenesis of an endothelium The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. go.json http://purl.obolibrary.org/obo/GO_0003159 GO:0003158 biolink:BiologicalProcess endothelium development The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. go.json http://purl.obolibrary.org/obo/GO_0003158 GO:0003153 biolink:BiologicalProcess closure of embryonic heart tube Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold. go.json http://purl.obolibrary.org/obo/GO_0003153 GO:0003152 biolink:BiologicalProcess morphogenesis of an epithelial fold involved in embryonic heart tube formation The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. go.json http://purl.obolibrary.org/obo/GO_0003152 GO:0003155 biolink:BiologicalProcess obsolete BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry. go.json BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_0003155 GO:0003154 biolink:BiologicalProcess obsolete BMP signaling pathway involved in determination of left/right symmetry OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry. go.json BMP signaling pathway involved in determination of left/right asymmetry|BMP signalling pathway involved in determination of left/right symmetry True http://purl.obolibrary.org/obo/GO_0003154 GO:0003151 biolink:BiologicalProcess outflow tract morphogenesis The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. go.json http://purl.obolibrary.org/obo/GO_0003151 GO:0003150 biolink:BiologicalProcess muscular septum morphogenesis The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. go.json http://purl.obolibrary.org/obo/GO_0003150 GO:0003168 biolink:BiologicalProcess Purkinje myocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. go.json cardiac Purkinje fiber cell differentiation http://purl.obolibrary.org/obo/GO_0003168 GO:0003167 biolink:BiologicalProcess atrioventricular bundle cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers. go.json AV bundle cell differentiation http://purl.obolibrary.org/obo/GO_0003167 GO:0003169 biolink:BiologicalProcess coronary vein morphogenesis The process in which the anatomical structures of veins of the heart are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003169 GO:0003164 biolink:BiologicalProcess His-Purkinje system development The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. go.json http://purl.obolibrary.org/obo/GO_0003164 GO:0003163 biolink:BiologicalProcess sinoatrial node development The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. go.json SA node development|SAN development|sinus node development http://purl.obolibrary.org/obo/GO_0003163 GO:0003166 biolink:BiologicalProcess bundle of His development The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers. go.json atrioventricular bundle development http://purl.obolibrary.org/obo/GO_0003166 GO:0003165 biolink:BiologicalProcess Purkinje myocyte development The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. go.json cardiac Purkinje fiber development http://purl.obolibrary.org/obo/GO_0003165 GO:0003160 biolink:BiologicalProcess endocardium morphogenesis The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. go.json http://purl.obolibrary.org/obo/GO_0003160 GO:0003162 biolink:BiologicalProcess atrioventricular node development The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. go.json AV node development http://purl.obolibrary.org/obo/GO_0003162 GO:0003161 biolink:BiologicalProcess cardiac conduction system development The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. go.json cardiac impulse conducting system development|heart conduction system development http://purl.obolibrary.org/obo/GO_0003161 GO:0003139 biolink:BiologicalProcess secondary heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). go.json SHF specification|anterior heart field specification|second heart field specification http://purl.obolibrary.org/obo/GO_0003139 GO:0003138 biolink:BiologicalProcess primary heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. go.json FHS specification|first heart field specification http://purl.obolibrary.org/obo/GO_0003138 GO:0003135 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in heart induction The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction. go.json fibroblast growth factor receptor signalling pathway involved in heart induction http://purl.obolibrary.org/obo/GO_0003135 GO:0003134 biolink:BiologicalProcess endodermal-mesodermal cell signaling involved in heart induction Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction. go.json endodermal-mesodermal cell signalling involved in heart induction http://purl.obolibrary.org/obo/GO_0003134 GO:0003137 biolink:BiologicalProcess Notch signaling pathway involved in heart induction The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. go.json Notch signalling pathway involved in heart induction http://purl.obolibrary.org/obo/GO_0003137 GO:0003136 biolink:BiologicalProcess negative regulation of heart induction by canonical Wnt signaling pathway Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction. go.json negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of heart induction by canonical Wnt receptor signalling pathway|negative regulation of heart induction by canonical Wnt-activated signaling pathway http://purl.obolibrary.org/obo/GO_0003136 GO:0003131 biolink:BiologicalProcess mesodermal-endodermal cell signaling Any process that mediates the transfer of information from mesodermal cells to endodermal cells. go.json mesodermal-endodermal cell signalling http://purl.obolibrary.org/obo/GO_0003131 GO:0003130 biolink:BiologicalProcess obsolete BMP signaling pathway involved in heart induction OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction. go.json BMP signalling pathway involved in heart induction True http://purl.obolibrary.org/obo/GO_0003130 GO:0003133 biolink:BiologicalProcess endodermal-mesodermal cell signaling Any process that mediates the transfer of information from endodermal cells to mesodermal cells. go.json endodermal-mesodermal cell signalling http://purl.obolibrary.org/obo/GO_0003133 GO:0003132 biolink:BiologicalProcess mesodermal-endodermal cell signaling involved in heart induction Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction. go.json mesodermal-endodermal cell signalling involved in heart induction http://purl.obolibrary.org/obo/GO_0003132 GO:0003149 biolink:BiologicalProcess membranous septum morphogenesis The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. go.json http://purl.obolibrary.org/obo/GO_0003149 GO:0003146 biolink:BiologicalProcess heart jogging The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis. go.json cardiac jogging http://purl.obolibrary.org/obo/GO_0003146 GO:0003145 biolink:BiologicalProcess embryonic heart tube formation via epithelial folding The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. go.json http://purl.obolibrary.org/obo/GO_0003145 GO:0003148 biolink:BiologicalProcess outflow tract septum morphogenesis The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. go.json http://purl.obolibrary.org/obo/GO_0003148 GO:0003147 biolink:BiologicalProcess neural crest cell migration involved in heart formation The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. go.json http://purl.obolibrary.org/obo/GO_0003147 GO:0003142 biolink:BiologicalProcess cardiogenic plate morphogenesis The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. go.json cardiac crescent morphogenesis http://purl.obolibrary.org/obo/GO_0003142 GO:0003141 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination. go.json TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry|TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry|TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry|TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry|transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry|transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination|transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_0003141 GO:0003144 biolink:BiologicalProcess embryonic heart tube formation The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. go.json http://purl.obolibrary.org/obo/GO_0003144 GO:0003143 biolink:BiologicalProcess embryonic heart tube morphogenesis The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. go.json http://purl.obolibrary.org/obo/GO_0003143 GO:0003140 biolink:BiologicalProcess determination of left/right asymmetry in lateral mesoderm The establishment of the lateral mesoderm with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0003140 GO:0003117 biolink:BiologicalProcess regulation of vasoconstriction by circulating norepinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream. go.json regulation of vasoconstriction by circulating noradrenaline http://purl.obolibrary.org/obo/GO_0003117 GO:0003116 biolink:BiologicalProcess regulation of vasoconstriction by norepinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings. go.json http://purl.obolibrary.org/obo/GO_0003116 GO:0003119 biolink:BiologicalProcess regulation of vasoconstriction by neuronal epinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings. go.json regulation of vasoconstriction by neuronal adrenaline http://purl.obolibrary.org/obo/GO_0003119 GO:0003118 biolink:BiologicalProcess regulation of vasoconstriction by neuronal norepinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings. go.json regulation of vasoconstriction by neuronal noradrenaline http://purl.obolibrary.org/obo/GO_0003118 GO:0003113 biolink:BiologicalProcess positive regulation of heart rate by neuronal norepinephrine The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction. go.json positive regulation of heart rate by neuronal noradrenaline http://purl.obolibrary.org/obo/GO_0003113 GO:0003112 biolink:BiologicalProcess positive regulation of heart rate by neuronal epinephrine The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction. go.json positive regulation of heart rate by neuronal adrenaline http://purl.obolibrary.org/obo/GO_0003112 GO:0003115 biolink:BiologicalProcess regulation of vasoconstriction by epinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings. go.json http://purl.obolibrary.org/obo/GO_0003115 GO:0003114 biolink:BiologicalProcess positive regulation of heart rate by circulating norepinephrine The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction. go.json positive regulation of heart rate by circulating noradrenaline http://purl.obolibrary.org/obo/GO_0003114 GO:0003111 biolink:BiologicalProcess positive regulation of heart rate by circulating epinephrine The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction. go.json positive regulation of heart rate by circulating adrenaline http://purl.obolibrary.org/obo/GO_0003111 GO:0003110 biolink:BiologicalProcess positive regulation of the force of heart contraction by neuronal norepinephrine The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction. go.json increased force of heart contraction by neuronal noradrenaline|increased force of heart contraction by neuronal norepinephrine http://purl.obolibrary.org/obo/GO_0003110 GO:0003128 biolink:BiologicalProcess heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop. go.json http://purl.obolibrary.org/obo/GO_0003128 GO:0003127 biolink:BiologicalProcess detection of nodal flow The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry. go.json http://purl.obolibrary.org/obo/GO_0003127 GO:0003129 biolink:BiologicalProcess heart induction The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. go.json http://purl.obolibrary.org/obo/GO_0003129 GO:0003124 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003124 GO:0003123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003123 GO:0003126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003126 GO:0003125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003125 GO:0003120 biolink:BiologicalProcess regulation of vasoconstriction by circulating epinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream. go.json regulation of vasoconstriction by circulating adrenaline http://purl.obolibrary.org/obo/GO_0003120 GO:0003122 biolink:BiologicalProcess norepinephrine-mediated vasodilation A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings. go.json regulation of vasodilation by circulating noradrenaline|regulation of vasodilation by circulating norepinephrine|regulation of vasodilation by neuronal noradrenaline|regulation of vasodilation by neuronal norepinephrine|regulation of vasodilation by noradrenaline|regulation of vasodilation by norepinephrine http://purl.obolibrary.org/obo/GO_0003122 GO:0003121 biolink:BiologicalProcess epinephrine-mediated vasodilation A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings. go.json regulation of vasodilation by adrenaline|regulation of vasodilation by circulating adrenaline|regulation of vasodilation by circulating epinephrine|regulation of vasodilation by epinephrine|regulation of vasodilation by neuronal adrenaline|regulation of vasodilation by neuronal epinephrine http://purl.obolibrary.org/obo/GO_0003121 GO:0003106 biolink:BiologicalProcess negative regulation of glomerular filtration by angiotensin The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. go.json angiotensin-mediated regulation of glomerular filtration|regulation of glomerular filtration by angiotensin http://purl.obolibrary.org/obo/GO_0003106 GO:0003105 biolink:BiologicalProcess negative regulation of glomerular filtration Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. go.json http://purl.obolibrary.org/obo/GO_0003105 GO:0003108 biolink:BiologicalProcess negative regulation of the force of heart contraction by chemical signal Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. go.json negative regulation of the force of heart muscle contraction by chemical signal http://purl.obolibrary.org/obo/GO_0003108 GO:0003107 biolink:BiologicalProcess obsolete positive regulation of natriuresis by angiotensin OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion. go.json angiotensin-mediated positive regulation of natriuresis|positive regulation of natriuresis by angiotensin True http://purl.obolibrary.org/obo/GO_0003107 GO:0003102 biolink:BiologicalProcess obsolete positive regulation of diuresis by angiotensin OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis. go.json angiotensin-mediated positive regulation of diuresis|positive regulation of diuresis by angiotensin True http://purl.obolibrary.org/obo/GO_0003102 GO:0003101 biolink:BiologicalProcess regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system. go.json regulation of blood pressure by circulating adrenaline-noradrenaline http://purl.obolibrary.org/obo/GO_0003101 GO:0003104 biolink:BiologicalProcess positive regulation of glomerular filtration Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. go.json http://purl.obolibrary.org/obo/GO_0003104 GO:0003103 biolink:BiologicalProcess obsolete positive regulation of diuresis OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion. go.json positive regulation of diuresis True http://purl.obolibrary.org/obo/GO_0003103 GO:0003100 biolink:BiologicalProcess regulation of systemic arterial blood pressure by endothelin The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor. go.json http://purl.obolibrary.org/obo/GO_0003100 GO:0003109 biolink:BiologicalProcess positive regulation of the force of heart contraction by circulating norepinephrine The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction. go.json increased force of heart contraction by circulating noradrenaline|increased force of heart contraction by circulating norepinephrine http://purl.obolibrary.org/obo/GO_0003109 GO:1904039 biolink:BiologicalProcess negative regulation of iron export across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json down regulation of ferrous iron export|down regulation of iron(2+) export|down-regulation of ferrous iron export|down-regulation of iron(2+) export|downregulation of ferrous iron export|downregulation of iron(2+) export|inhibition of ferrous iron export|inhibition of iron(2+) export|negative regulation of ferrous iron export|negative regulation of iron(2+) export http://purl.obolibrary.org/obo/GO_1904039 GO:1904038 biolink:BiologicalProcess regulation of iron export across plasma membrane Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json regulation of ferrous iron export|regulation of iron(2+) export http://purl.obolibrary.org/obo/GO_1904038 GO:1904037 biolink:BiologicalProcess positive regulation of epithelial cell apoptotic process Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. go.json activation of epithelial cell apoptosis|activation of epithelial cell apoptotic process|activation of epitheliocyte apoptosis|activation of epitheliocyte apoptotic process|positive regulation of epithelial cell apoptosis|positive regulation of epitheliocyte apoptosis|positive regulation of epitheliocyte apoptotic process|up regulation of epithelial cell apoptosis|up regulation of epithelial cell apoptotic process|up regulation of epitheliocyte apoptosis|up regulation of epitheliocyte apoptotic process|up-regulation of epithelial cell apoptosis|up-regulation of epithelial cell apoptotic process|up-regulation of epitheliocyte apoptosis|up-regulation of epitheliocyte apoptotic process|upregulation of epithelial cell apoptosis|upregulation of epithelial cell apoptotic process|upregulation of epitheliocyte apoptosis|upregulation of epitheliocyte apoptotic process http://purl.obolibrary.org/obo/GO_1904037 GO:1904036 biolink:BiologicalProcess negative regulation of epithelial cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. go.json down regulation of epithelial cell apoptosis|down regulation of epithelial cell apoptotic process|down regulation of epitheliocyte apoptosis|down regulation of epitheliocyte apoptotic process|down-regulation of epithelial cell apoptosis|down-regulation of epithelial cell apoptotic process|down-regulation of epitheliocyte apoptosis|down-regulation of epitheliocyte apoptotic process|downregulation of epithelial cell apoptosis|downregulation of epithelial cell apoptotic process|downregulation of epitheliocyte apoptosis|downregulation of epitheliocyte apoptotic process|inhibition of epithelial cell apoptosis|inhibition of epithelial cell apoptotic process|inhibition of epitheliocyte apoptosis|inhibition of epitheliocyte apoptotic process|negative regulation of epithelial cell apoptosis|negative regulation of epitheliocyte apoptosis|negative regulation of epitheliocyte apoptotic process http://purl.obolibrary.org/obo/GO_1904036 GO:1904046 biolink:BiologicalProcess negative regulation of vascular endothelial growth factor production Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production. go.json down regulation of VEGF production|down regulation of vascular endothelial growth factor production|down-regulation of VEGF production|down-regulation of vascular endothelial growth factor production|downregulation of VEGF production|downregulation of vascular endothelial growth factor production|inhibition of VEGF production|inhibition of vascular endothelial growth factor production|negative regulation of VEGF production http://purl.obolibrary.org/obo/GO_1904046 GO:1904045 biolink:BiologicalProcess cellular response to aldosterone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_1904045 GO:1904044 biolink:BiologicalProcess response to aldosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_1904044 GO:1904043 biolink:BiologicalProcess positive regulation of cystathionine beta-synthase activity Any process that activates or increases the frequency, rate or extent of cystathionine beta-synthase activity. go.json activation of L-serine hydro-lyase (adding homocysteine)|activation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|activation of beta-thionase activity|activation of cystathionine beta-synthase activity|activation of methylcysteine synthase activity|activation of serine sulfhydrase activity|activation of serine sulfhydrylase activity|positive regulation of L-serine hydro-lyase (adding homocysteine)|positive regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|positive regulation of beta-thionase activity|positive regulation of methylcysteine synthase activity|positive regulation of serine sulfhydrase activity|positive regulation of serine sulfhydrylase activity|up regulation of L-serine hydro-lyase (adding homocysteine)|up regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|up regulation of beta-thionase activity|up regulation of cystathionine beta-synthase activity|up regulation of methylcysteine synthase activity|up regulation of serine sulfhydrase activity|up regulation of serine sulfhydrylase activity|up-regulation of L-serine hydro-lyase (adding homocysteine)|up-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|up-regulation of beta-thionase activity|up-regulation of cystathionine beta-synthase activity|up-regulation of methylcysteine synthase activity|up-regulation of serine sulfhydrase activity|up-regulation of serine sulfhydrylase activity|upregulation of L-serine hydro-lyase (adding homocysteine)|upregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|upregulation of beta-thionase activity|upregulation of cystathionine beta-synthase activity|upregulation of methylcysteine synthase activity|upregulation of serine sulfhydrase activity|upregulation of serine sulfhydrylase activity http://purl.obolibrary.org/obo/GO_1904043 gocheck_do_not_annotate GO:1904042 biolink:BiologicalProcess negative regulation of cystathionine beta-synthase activity Any process that stops, prevents or reduces the frequency, rate or extent of cystathionine beta-synthase activity. go.json down regulation of L-serine hydro-lyase (adding homocysteine)|down regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|down regulation of beta-thionase activity|down regulation of cystathionine beta-synthase activity|down regulation of methylcysteine synthase activity|down regulation of serine sulfhydrase activity|down regulation of serine sulfhydrylase activity|down-regulation of L-serine hydro-lyase (adding homocysteine)|down-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|down-regulation of beta-thionase activity|down-regulation of cystathionine beta-synthase activity|down-regulation of methylcysteine synthase activity|down-regulation of serine sulfhydrase activity|down-regulation of serine sulfhydrylase activity|downregulation of L-serine hydro-lyase (adding homocysteine)|downregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|downregulation of beta-thionase activity|downregulation of cystathionine beta-synthase activity|downregulation of methylcysteine synthase activity|downregulation of serine sulfhydrase activity|downregulation of serine sulfhydrylase activity|inhibition of L-serine hydro-lyase (adding homocysteine)|inhibition of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|inhibition of beta-thionase activity|inhibition of cystathionine beta-synthase activity|inhibition of methylcysteine synthase activity|inhibition of serine sulfhydrase activity|inhibition of serine sulfhydrylase activity|negative regulation of L-serine hydro-lyase (adding homocysteine)|negative regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|negative regulation of beta-thionase activity|negative regulation of methylcysteine synthase activity|negative regulation of serine sulfhydrase activity|negative regulation of serine sulfhydrylase activity http://purl.obolibrary.org/obo/GO_1904042 gocheck_do_not_annotate GO:0052281 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052281 GO:1904041 biolink:BiologicalProcess regulation of cystathionine beta-synthase activity Any process that modulates the frequency, rate or extent of cystathionine beta-synthase activity. go.json regulation of L-serine hydro-lyase (adding homocysteine)|regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|regulation of beta-thionase activity|regulation of methylcysteine synthase activity|regulation of serine sulfhydrase activity|regulation of serine sulfhydrylase activity http://purl.obolibrary.org/obo/GO_1904041 gocheck_do_not_annotate GO:0052280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052280 GO:1904040 biolink:BiologicalProcess positive regulation of iron export across plasma membrane Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json activation of ferrous iron export|activation of iron(2+) export|positive regulation of ferrous iron export|positive regulation of iron(2+) export|up regulation of ferrous iron export|up regulation of iron(2+) export|up-regulation of ferrous iron export|up-regulation of iron(2+) export|upregulation of ferrous iron export|upregulation of iron(2+) export http://purl.obolibrary.org/obo/GO_1904040 GO:0052285 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052285 GO:0052284 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052284 GO:0052283 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052283 GO:0052282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052282 GO:0052289 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052289 GO:0052288 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052288 GO:0052287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052287 GO:0052286 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052286 GO:1904049 biolink:BiologicalProcess negative regulation of spontaneous neurotransmitter secretion Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion. go.json down regulation of spontaneous neurotransmitter secretion|down regulation of stimulus-independent neurotransmitter secretion|down-regulation of spontaneous neurotransmitter secretion|down-regulation of stimulus-independent neurotransmitter secretion|downregulation of spontaneous neurotransmitter secretion|downregulation of stimulus-independent neurotransmitter secretion|inhibition of spontaneous neurotransmitter secretion|inhibition of stimulus-independent neurotransmitter secretion|negative regulation of stimulus-independent neurotransmitter secretion http://purl.obolibrary.org/obo/GO_1904049 GO:1904048 biolink:BiologicalProcess regulation of spontaneous neurotransmitter secretion Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion. go.json regulation of stimulus-independent neurotransmitter secretion http://purl.obolibrary.org/obo/GO_1904048 GO:1904047 biolink:MolecularActivity S-adenosyl-L-methionine binding Binding to S-adenosyl-L-methionine. Reactome:R-HSA-947535 go.json radical SAM enzyme activity http://purl.obolibrary.org/obo/GO_1904047 GO:1904057 biolink:BiologicalProcess negative regulation of sensory perception of pain Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. go.json down regulation of nociception|down regulation of perception of physiological pain|down regulation of sensory perception of pain|down-regulation of nociception|down-regulation of perception of physiological pain|down-regulation of sensory perception of pain|downregulation of nociception|downregulation of perception of physiological pain|downregulation of sensory perception of pain|inhibition of nociception|inhibition of perception of physiological pain|inhibition of sensory perception of pain|negative regulation of nociception|negative regulation of perception of physiological pain http://purl.obolibrary.org/obo/GO_1904057 GO:1904056 biolink:BiologicalProcess positive regulation of cholangiocyte proliferation Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. go.json activation of cholangiocyte proliferation|activation of hepatoblast proliferation|positive regulation of hepatoblast proliferation|up regulation of cholangiocyte proliferation|up regulation of hepatoblast proliferation|up-regulation of cholangiocyte proliferation|up-regulation of hepatoblast proliferation|upregulation of cholangiocyte proliferation|upregulation of hepatoblast proliferation http://purl.obolibrary.org/obo/GO_1904056 GO:1904055 biolink:BiologicalProcess negative regulation of cholangiocyte proliferation Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. go.json down regulation of cholangiocyte proliferation|down regulation of hepatoblast proliferation|down-regulation of cholangiocyte proliferation|down-regulation of hepatoblast proliferation|downregulation of cholangiocyte proliferation|downregulation of hepatoblast proliferation|inhibition of cholangiocyte proliferation|inhibition of hepatoblast proliferation|negative regulation of hepatoblast proliferation http://purl.obolibrary.org/obo/GO_1904055 GO:1904054 biolink:BiologicalProcess regulation of cholangiocyte proliferation Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. go.json regulation of hepatoblast proliferation http://purl.obolibrary.org/obo/GO_1904054 GO:1904053 biolink:BiologicalProcess positive regulation of protein targeting to vacuole involved in autophagy Any process that activates or increases the frequency, rate or extent of protein targeting to vacuole involved in autophagy. go.json activation of protein targeting to vacuole involved in autophagy|up regulation of protein targeting to vacuole involved in autophagy|up-regulation of protein targeting to vacuole involved in autophagy|upregulation of protein targeting to vacuole involved in autophagy http://purl.obolibrary.org/obo/GO_1904053 GO:0052292 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052292 GO:1904052 biolink:BiologicalProcess negative regulation of protein targeting to vacuole involved in autophagy Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuole involved in autophagy. go.json down regulation of protein targeting to vacuole involved in autophagy|down-regulation of protein targeting to vacuole involved in autophagy|downregulation of protein targeting to vacuole involved in autophagy|inhibition of protein targeting to vacuole involved in autophagy http://purl.obolibrary.org/obo/GO_1904052 GO:0052291 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052291 GO:1904051 biolink:BiologicalProcess regulation of protein targeting to vacuole involved in autophagy Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy. go.json http://purl.obolibrary.org/obo/GO_1904051 GO:0052290 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052290 GO:1904050 biolink:BiologicalProcess positive regulation of spontaneous neurotransmitter secretion Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion. go.json activation of spontaneous neurotransmitter secretion|activation of stimulus-independent neurotransmitter secretion|positive regulation of stimulus-independent neurotransmitter secretion|up regulation of spontaneous neurotransmitter secretion|up regulation of stimulus-independent neurotransmitter secretion|up-regulation of spontaneous neurotransmitter secretion|up-regulation of stimulus-independent neurotransmitter secretion|upregulation of spontaneous neurotransmitter secretion|upregulation of stimulus-independent neurotransmitter secretion http://purl.obolibrary.org/obo/GO_1904050 GO:0052296 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052296 GO:0052295 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052295 GO:0052294 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052294 GO:0052293 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052293 GO:0052299 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052299 GO:0052298 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052298 GO:0052297 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052297 GO:1904059 biolink:BiologicalProcess regulation of locomotor rhythm Any process that modulates the frequency, rate or extent of locomotor rhythm. go.json regulation of circadian locomotor activity rhythm http://purl.obolibrary.org/obo/GO_1904059 GO:1904058 biolink:BiologicalProcess positive regulation of sensory perception of pain Any process that activates or increases the frequency, rate or extent of sensory perception of pain. go.json activation of nociception|activation of perception of physiological pain|activation of sensory perception of pain|positive regulation of nociception|positive regulation of perception of physiological pain|up regulation of nociception|up regulation of perception of physiological pain|up regulation of sensory perception of pain|up-regulation of nociception|up-regulation of perception of physiological pain|up-regulation of sensory perception of pain|upregulation of nociception|upregulation of perception of physiological pain|upregulation of sensory perception of pain http://purl.obolibrary.org/obo/GO_1904058 GO:1904068 biolink:BiologicalProcess G protein-coupled receptor signaling pathway involved in social behavior Any G protein-coupled receptor signaling pathway that is involved in social behavior. go.json G protein coupled receptor protein signaling pathway involved in cooperative behavior|G protein coupled receptor protein signaling pathway involved in social behavior|G protein coupled receptor protein signaling pathway involved in social behaviour|G protein coupled receptor protein signalling pathway involved in cooperative behavior|G protein coupled receptor protein signalling pathway involved in social behavior|G protein coupled receptor protein signalling pathway involved in social behaviour|G-protein coupled receptor protein signal transduction involved in cooperative behavior|G-protein coupled receptor protein signal transduction involved in social behavior|G-protein coupled receptor protein signal transduction involved in social behaviour|G-protein coupled receptor protein signaling pathway involved in cooperative behavior|G-protein coupled receptor protein signaling pathway involved in social behavior|G-protein coupled receptor protein signaling pathway involved in social behaviour|G-protein coupled receptor signaling pathway involved in cooperative behavior|G-protein coupled receptor signaling pathway involved in social behavior|G-protein coupled receptor signaling pathway involved in social behaviour|G-protein coupled receptor signalling pathway involved in cooperative behavior|G-protein coupled receptor signalling pathway involved in social behavior|G-protein coupled receptor signalling pathway involved in social behaviour|G-protein-coupled receptor protein signaling pathway involved in cooperative behavior|G-protein-coupled receptor protein signaling pathway involved in social behavior|G-protein-coupled receptor protein signaling pathway involved in social behaviour|G-protein-coupled receptor protein signalling pathway involved in cooperative behavior|G-protein-coupled receptor protein signalling pathway involved in social behavior|G-protein-coupled receptor protein signalling pathway involved in social behaviour|GPCR signaling pathway involved in cooperative behavior|GPCR signaling pathway involved in social behavior|GPCR signaling pathway involved in social behaviour|GPCR signalling pathway involved in cooperative behavior|GPCR signalling pathway involved in social behavior|GPCR signalling pathway involved in social behaviour http://purl.obolibrary.org/obo/GO_1904068 GO:1904067 biolink:MolecularActivity ascr#2 binding Binding to ascr#2. go.json http://purl.obolibrary.org/obo/GO_1904067 GO:1904066 biolink:BiologicalProcess G protein-coupled receptor signaling pathway involved in dauer larval development Any G protein-coupled receptor signaling pathway that is involved in dauer larval development. go.json G protein coupled receptor protein signaling pathway involved in dauer larval development|G protein coupled receptor protein signalling pathway involved in dauer larval development|G-protein coupled receptor protein signal transduction involved in dauer larval development|G-protein coupled receptor protein signaling pathway involved in dauer larval development|G-protein coupled receptor signalling pathway involved in dauer larval development|G-protein-coupled receptor protein signalling pathway involved in dauer larval development|GPCR signaling pathway involved in dauer larval development|GPCR signalling pathway involved in dauer larval development http://purl.obolibrary.org/obo/GO_1904066 GO:1904065 biolink:BiologicalProcess G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission. go.json G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion|G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission|G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion|G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion|G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion|G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion|acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion|acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission|acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion|acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion|acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion|acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion|muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion|muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission|muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion|muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion|muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion|muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion http://purl.obolibrary.org/obo/GO_1904065 GO:1904064 biolink:BiologicalProcess positive regulation of cation transmembrane transport Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. go.json activation of cation transmembrane transport|up regulation of cation transmembrane transport|up-regulation of cation transmembrane transport|upregulation of cation transmembrane transport http://purl.obolibrary.org/obo/GO_1904064 GO:1904063 biolink:BiologicalProcess negative regulation of cation transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. go.json down regulation of cation transmembrane transport|down-regulation of cation transmembrane transport|downregulation of cation transmembrane transport|inhibition of cation transmembrane transport http://purl.obolibrary.org/obo/GO_1904063 GO:1904062 biolink:BiologicalProcess regulation of monoatomic cation transmembrane transport Any process that modulates the frequency, rate or extent of cation transmembrane transport. go.json regulation of cation transmembrane transport http://purl.obolibrary.org/obo/GO_1904062 GO:1904061 biolink:BiologicalProcess positive regulation of locomotor rhythm Any process that activates or increases the frequency, rate or extent of locomotor rhythm. go.json activation of circadian locomotor activity rhythm|activation of locomotor rhythm|positive regulation of circadian locomotor activity rhythm|up regulation of circadian locomotor activity rhythm|up regulation of locomotor rhythm|up-regulation of circadian locomotor activity rhythm|up-regulation of locomotor rhythm|upregulation of circadian locomotor activity rhythm|upregulation of locomotor rhythm http://purl.obolibrary.org/obo/GO_1904061 GO:1904060 biolink:BiologicalProcess negative regulation of locomotor rhythm Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm. go.json down regulation of circadian locomotor activity rhythm|down regulation of locomotor rhythm|down-regulation of circadian locomotor activity rhythm|down-regulation of locomotor rhythm|downregulation of circadian locomotor activity rhythm|downregulation of locomotor rhythm|inhibition of circadian locomotor activity rhythm|inhibition of locomotor rhythm|negative regulation of circadian locomotor activity rhythm http://purl.obolibrary.org/obo/GO_1904060 GO:1904069 biolink:BiologicalProcess ascaroside metabolic process The chemical reactions and pathways involving ascaroside. go.json ascaroside metabolism http://purl.obolibrary.org/obo/GO_1904069 GO:1904079 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in negative regulation of neuron apoptotic process. go.json down regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|down regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|down regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|down regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|down regulation of global transcription from RNA polymerase II promoter involved in neuron survival|down regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|down regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|down regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|down regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|down regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|down regulation of transcription from RNA polymerase II promoter involved in neuron survival|down-regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|down-regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|down-regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|down-regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|down-regulation of global transcription from RNA polymerase II promoter involved in neuron survival|down-regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|down-regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|down-regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|down-regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|down-regulation of transcription from RNA polymerase II promoter involved in neuron survival|downregulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|downregulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|downregulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|downregulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|downregulation of global transcription from RNA polymerase II promoter involved in neuron survival|downregulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|downregulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|downregulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|downregulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|downregulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|downregulation of transcription from RNA polymerase II promoter involved in neuron survival|inhibition of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|inhibition of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|inhibition of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|inhibition of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|inhibition of global transcription from RNA polymerase II promoter involved in neuron survival|inhibition of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|inhibition of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|inhibition of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|inhibition of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|inhibition of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|inhibition of transcription from RNA polymerase II promoter involved in neuron survival|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|negative regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron survival|negative regulation of global transcription from Pol II promoter involved in down regulation of neuron apoptosis|negative regulation of global transcription from Pol II promoter involved in down-regulation of neuron apoptosis|negative regulation of global transcription from Pol II promoter involved in downregulation of neuron apoptosis|negative regulation of global transcription from Pol II promoter involved in inhibition of neuron apoptosis|negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptosis|negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptotic process|negative regulation of global transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons|negative regulation of global transcription from Pol II promoter involved in neuron survival|negative regulation of transcription from Pol II promoter involved in down regulation of neuron apoptosis|negative regulation of transcription from Pol II promoter involved in down-regulation of neuron apoptosis|negative regulation of transcription from Pol II promoter involved in downregulation of neuron apoptosis|negative regulation of transcription from Pol II promoter involved in inhibition of neuron apoptosis|negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptosis|negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptotic process|negative regulation of transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons|negative regulation of transcription from Pol II promoter involved in neuron survival|negative regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process|negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons|negative regulation of transcription from RNA polymerase II promoter involved in neuron survival|negative regulation of transcription from RNA polymerase II promoter, global involved in down regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter, global involved in down-regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter, global involved in downregulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter, global involved in inhibition of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptotic process|negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of programmed cell death, neurons|negative regulation of transcription from RNA polymerase II promoter, global involved in neuron survival True http://purl.obolibrary.org/obo/GO_1904079 GO:1904078 biolink:BiologicalProcess positive regulation of estrogen biosynthetic process Any process that activates or increases the frequency, rate or extent of estrogen biosynthetic process. go.json activation of estrogen anabolism|activation of estrogen biosynthesis|activation of estrogen biosynthetic process|activation of estrogen formation|activation of estrogen synthesis|activation of oestrogen biosynthesis|activation of oestrogen biosynthetic process|positive regulation of estrogen anabolism|positive regulation of estrogen biosynthesis|positive regulation of estrogen formation|positive regulation of estrogen synthesis|positive regulation of oestrogen biosynthesis|positive regulation of oestrogen biosynthetic process|up regulation of estrogen anabolism|up regulation of estrogen biosynthesis|up regulation of estrogen biosynthetic process|up regulation of estrogen formation|up regulation of estrogen synthesis|up regulation of oestrogen biosynthesis|up regulation of oestrogen biosynthetic process|up-regulation of estrogen anabolism|up-regulation of estrogen biosynthesis|up-regulation of estrogen biosynthetic process|up-regulation of estrogen formation|up-regulation of estrogen synthesis|up-regulation of oestrogen biosynthesis|up-regulation of oestrogen biosynthetic process|upregulation of estrogen anabolism|upregulation of estrogen biosynthesis|upregulation of estrogen biosynthetic process|upregulation of estrogen formation|upregulation of estrogen synthesis|upregulation of oestrogen biosynthesis|upregulation of oestrogen biosynthetic process http://purl.obolibrary.org/obo/GO_1904078 GO:1904077 biolink:BiologicalProcess negative regulation of estrogen biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process. go.json down regulation of estrogen anabolism|down regulation of estrogen biosynthesis|down regulation of estrogen biosynthetic process|down regulation of estrogen formation|down regulation of estrogen synthesis|down regulation of oestrogen biosynthesis|down regulation of oestrogen biosynthetic process|down-regulation of estrogen anabolism|down-regulation of estrogen biosynthesis|down-regulation of estrogen biosynthetic process|down-regulation of estrogen formation|down-regulation of estrogen synthesis|down-regulation of oestrogen biosynthesis|down-regulation of oestrogen biosynthetic process|downregulation of estrogen anabolism|downregulation of estrogen biosynthesis|downregulation of estrogen biosynthetic process|downregulation of estrogen formation|downregulation of estrogen synthesis|downregulation of oestrogen biosynthesis|downregulation of oestrogen biosynthetic process|inhibition of estrogen anabolism|inhibition of estrogen biosynthesis|inhibition of estrogen biosynthetic process|inhibition of estrogen formation|inhibition of estrogen synthesis|inhibition of oestrogen biosynthesis|inhibition of oestrogen biosynthetic process|negative regulation of estrogen anabolism|negative regulation of estrogen biosynthesis|negative regulation of estrogen formation|negative regulation of estrogen synthesis|negative regulation of oestrogen biosynthesis|negative regulation of oestrogen biosynthetic process http://purl.obolibrary.org/obo/GO_1904077 GO:1904076 biolink:BiologicalProcess regulation of estrogen biosynthetic process Any process that modulates the frequency, rate or extent of estrogen biosynthetic process. go.json regulation of estrogen anabolism|regulation of estrogen biosynthesis|regulation of estrogen formation|regulation of estrogen synthesis|regulation of oestrogen biosynthesis|regulation of oestrogen biosynthetic process http://purl.obolibrary.org/obo/GO_1904076 GO:1904075 biolink:BiologicalProcess positive regulation of trophectodermal cell proliferation Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. go.json activation of trophectoderm cell proliferation|activation of trophectodermal cell proliferation|positive regulation of trophectoderm cell proliferation|up regulation of trophectoderm cell proliferation|up regulation of trophectodermal cell proliferation|up-regulation of trophectoderm cell proliferation|up-regulation of trophectodermal cell proliferation|upregulation of trophectoderm cell proliferation|upregulation of trophectodermal cell proliferation http://purl.obolibrary.org/obo/GO_1904075 GO:1904074 biolink:BiologicalProcess negative regulation of trophectodermal cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. go.json down regulation of trophectoderm cell proliferation|down regulation of trophectodermal cell proliferation|down-regulation of trophectoderm cell proliferation|down-regulation of trophectodermal cell proliferation|downregulation of trophectoderm cell proliferation|downregulation of trophectodermal cell proliferation|inhibition of trophectoderm cell proliferation|inhibition of trophectodermal cell proliferation|negative regulation of trophectoderm cell proliferation http://purl.obolibrary.org/obo/GO_1904074 GO:1904073 biolink:BiologicalProcess regulation of trophectodermal cell proliferation Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. go.json regulation of trophectoderm cell proliferation http://purl.obolibrary.org/obo/GO_1904073 GO:1904072 biolink:BiologicalProcess presynaptic active zone disassembly The disaggregation of a presynaptic active zone into its constituent components. go.json pre-synaptic active zone component disassembly|pre-synaptic active zone disassembly http://purl.obolibrary.org/obo/GO_1904072 GO:1904071 biolink:BiologicalProcess presynaptic active zone assembly The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. go.json pre-synaptic active zone assembly|pre-synaptic active zone component assembly|pre-synaptic active zone component formation|pre-synaptic active zone formation|presynaptic active zone formation http://purl.obolibrary.org/obo/GO_1904071 GO:1904070 biolink:BiologicalProcess ascaroside biosynthetic process The chemical reactions and pathways resulting in the formation of ascaroside. go.json ascaroside anabolism|ascaroside biosynthesis|ascaroside formation|ascaroside synthesis http://purl.obolibrary.org/obo/GO_1904070 GO:1904089 biolink:BiologicalProcess obsolete negative regulation of neuron apoptotic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of neuron apoptotic process. go.json negative regulation of neuron apoptosis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of programmed cell death, neurons by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1904089 GO:1904088 biolink:BiologicalProcess positive regulation of epiboly involved in gastrulation with mouth forming second Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second. go.json activation of epiboly involved in gastrulation with mouth forming second|up regulation of epiboly involved in gastrulation with mouth forming second|up-regulation of epiboly involved in gastrulation with mouth forming second|upregulation of epiboly involved in gastrulation with mouth forming second http://purl.obolibrary.org/obo/GO_1904088 GO:1904087 biolink:BiologicalProcess negative regulation of epiboly involved in gastrulation with mouth forming second Any process that stops, prevents or reduces the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second. go.json down regulation of epiboly involved in gastrulation with mouth forming second|down-regulation of epiboly involved in gastrulation with mouth forming second|downregulation of epiboly involved in gastrulation with mouth forming second|inhibition of epiboly involved in gastrulation with mouth forming second http://purl.obolibrary.org/obo/GO_1904087 GO:1904086 biolink:BiologicalProcess regulation of epiboly involved in gastrulation with mouth forming second Any process that modulates the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second. go.json http://purl.obolibrary.org/obo/GO_1904086 GO:1904085 biolink:BiologicalProcess obsolete positive regulation of epiboly OBSOLETE. Any process that activates or increases the frequency, rate or extent of epiboly. go.json activation of epiboly|positive regulation of epiboly|up regulation of epiboly|up-regulation of epiboly|upregulation of epiboly True http://purl.obolibrary.org/obo/GO_1904085 GO:1904084 biolink:BiologicalProcess obsolete negative regulation of epiboly OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of epiboly. go.json down regulation of epiboly|down-regulation of epiboly|downregulation of epiboly|inhibition of epiboly|negative regulation of epiboly True http://purl.obolibrary.org/obo/GO_1904084 GO:1904083 biolink:BiologicalProcess obsolete regulation of epiboly OBSOLETE. Any process that modulates the frequency, rate or extent of epiboly. go.json regulation of epiboly True http://purl.obolibrary.org/obo/GO_1904083 GO:1904082 biolink:BiologicalProcess pyrimidine nucleobase transmembrane transport The process in which pyrimidine is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904082 GO:1904081 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation. go.json activation of global transcription from RNA polymerase II promoter involved in neuron differentiation|activation of transcription from RNA polymerase II promoter involved in neuron differentiation|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation|positive regulation of global transcription from Pol II promoter involved in neuron differentiation|positive regulation of transcription from Pol II promoter involved in neuron differentiation|positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation|stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation|stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation|up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation|up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation|up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation|up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation|upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation|upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation True http://purl.obolibrary.org/obo/GO_1904081 GO:1904080 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron fate specification. go.json activation of global transcription from RNA polymerase II promoter involved in neuron fate specification|activation of transcription from RNA polymerase II promoter involved in neuron fate specification|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron fate specification|positive regulation of global transcription from Pol II promoter involved in neuron fate specification|positive regulation of transcription from Pol II promoter involved in neuron fate specification|positive regulation of transcription from RNA polymerase II promoter, global involved in neuron fate specification|stimulation of global transcription from RNA polymerase II promoter involved in neuron fate specification|stimulation of transcription from RNA polymerase II promoter involved in neuron fate specification|up regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification|up regulation of transcription from RNA polymerase II promoter involved in neuron fate specification|up-regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification|up-regulation of transcription from RNA polymerase II promoter involved in neuron fate specification|upregulation of global transcription from RNA polymerase II promoter involved in neuron fate specification|upregulation of transcription from RNA polymerase II promoter involved in neuron fate specification True http://purl.obolibrary.org/obo/GO_1904080 GO:1904099 biolink:BiologicalProcess negative regulation of protein O-linked glycosylation Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation. go.json down regulation of protein O-linked glycosylation|down regulation of protein amino acid O-linked glycosylation|down-regulation of protein O-linked glycosylation|down-regulation of protein amino acid O-linked glycosylation|downregulation of protein O-linked glycosylation|downregulation of protein amino acid O-linked glycosylation|inhibition of protein O-linked glycosylation|inhibition of protein amino acid O-linked glycosylation|negative regulation of protein amino acid O-linked glycosylation http://purl.obolibrary.org/obo/GO_1904099 GO:1904098 biolink:BiologicalProcess regulation of protein O-linked glycosylation Any process that modulates the frequency, rate or extent of protein O-linked glycosylation. go.json regulation of protein amino acid O-linked glycosylation http://purl.obolibrary.org/obo/GO_1904098 GO:1904097 biolink:CellularComponent acid phosphatase complex A protein complex which is capable of acid phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_1904097 GO:1904096 biolink:CellularComponent protein tyrosine phosphatase complex A protein complex which is capable of protein tyrosine phosphatase activity. go.json http://purl.obolibrary.org/obo/GO_1904096 GO:1904095 biolink:BiologicalProcess negative regulation of endosperm development Any process that stops, prevents or reduces the frequency, rate or extent of endosperm development. go.json down regulation of endosperm development|down-regulation of endosperm development|downregulation of endosperm development|inhibition of endosperm development http://purl.obolibrary.org/obo/GO_1904095 GO:1904094 biolink:BiologicalProcess positive regulation of autophagic cell death Any process that activates or increases the frequency, rate or extent of autophagic cell death. go.json activation of autophagic cell death|activation of programmed cell death by macroautophagy|activation of type II programmed cell death|positive regulation of programmed cell death by macroautophagy|positive regulation of type II programmed cell death|up regulation of autophagic cell death|up regulation of programmed cell death by macroautophagy|up regulation of type II programmed cell death|up-regulation of autophagic cell death|up-regulation of programmed cell death by macroautophagy|up-regulation of type II programmed cell death|upregulation of autophagic cell death|upregulation of programmed cell death by macroautophagy|upregulation of type II programmed cell death http://purl.obolibrary.org/obo/GO_1904094 GO:1904093 biolink:BiologicalProcess negative regulation of autophagic cell death Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death. go.json down regulation of autophagic cell death|down regulation of programmed cell death by macroautophagy|down regulation of type II programmed cell death|down-regulation of autophagic cell death|down-regulation of programmed cell death by macroautophagy|down-regulation of type II programmed cell death|downregulation of autophagic cell death|downregulation of programmed cell death by macroautophagy|downregulation of type II programmed cell death|inhibition of autophagic cell death|inhibition of programmed cell death by macroautophagy|inhibition of type II programmed cell death|negative regulation of programmed cell death by macroautophagy|negative regulation of type II programmed cell death http://purl.obolibrary.org/obo/GO_1904093 GO:1904092 biolink:BiologicalProcess regulation of autophagic cell death Any process that modulates the frequency, rate or extent of autophagic cell death. go.json regulation of autophagic death|regulation of programmed cell death by autophagy|regulation of programmed cell death by macroautophagy|regulation of type II programmed cell death http://purl.obolibrary.org/obo/GO_1904092 GO:1904091 biolink:MolecularActivity non-ribosomal peptide synthetase activity Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. go.json PCP|peptidyl carrier protein|peptidyl carrier protein activity|peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis|peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process http://purl.obolibrary.org/obo/GO_1904091 GO:1904090 biolink:CellularComponent peptidase inhibitor complex A protein complex which is capable of peptidase inhibitor activity. go.json Cathepsin-B - cystatin-A complex http://purl.obolibrary.org/obo/GO_1904090 GO:0003299 biolink:BiologicalProcess muscle hypertrophy in response to stress The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. go.json http://purl.obolibrary.org/obo/GO_0003299 GO:0003296 biolink:BiologicalProcess apoptotic process involved in atrial ventricular junction remodeling Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction. go.json apoptosis involved in atrial ventricular junction remodelling|apoptosis involved in atrio-ventricular junction remodeling|apoptosis involved in atrio-ventricular junction remodelling|apoptosis involved in atrioventricular junction remodeling|apoptosis involved in atrioventricular junction remodelling http://purl.obolibrary.org/obo/GO_0003296 GO:0003295 biolink:BiologicalProcess cell proliferation involved in atrial ventricular junction remodeling The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction. go.json cell proliferation involved in atrial ventricular junction remodelling|cell proliferation involved in atrio-ventricular junction remodeling|cell proliferation involved in atrio-ventricular junction remodelling|cell proliferation involved in atrioventricular junction remodeling|cell proliferation involved in atrioventricular junction remodelling http://purl.obolibrary.org/obo/GO_0003295 GO:0003298 biolink:BiologicalProcess physiological muscle hypertrophy The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. go.json http://purl.obolibrary.org/obo/GO_0003298 GO:0003297 biolink:BiologicalProcess heart wedging The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0003297 GO:0003292 biolink:BiologicalProcess cardiac septum cell differentiation The process in which an endocardial cushion cell becomes a cell of a cardiac septum. go.json http://purl.obolibrary.org/obo/GO_0003292 GO:0003291 biolink:BiologicalProcess atrial septum intermedium morphogenesis The process in which anatomical structure of an atrial septum intermedium is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003291 GO:0003294 biolink:BiologicalProcess atrial ventricular junction remodeling The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle. go.json atrial ventricular junction remodelling|atrio-ventricular junction remodeling|atrioventricular junction remodeling http://purl.obolibrary.org/obo/GO_0003294 GO:0003293 biolink:BiologicalProcess heart valve cell differentiation The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve. go.json http://purl.obolibrary.org/obo/GO_0003293 GO:0052205 biolink:BiologicalProcess obsolete modulation of molecular function in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction. go.json modification of molecular function in other organism during symbiotic interaction|modification of protein function in other organism during symbiotic interaction|modulation of molecular function in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052205 GO:0052204 biolink:BiologicalProcess obsolete negative regulation of molecular function in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction. go.json down regulation of protein function in other organism during symbiotic interaction|down-regulation of protein function in other organism during symbiotic interaction|downregulation of protein function in other organism during symbiotic interaction|inhibition of protein function in other organism|inhibition of protein function in other organism during symbiotic interaction|negative regulation of protein function in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052204 GO:0052203 biolink:BiologicalProcess obsolete modulation of catalytic activity in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of enzyme activity within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052203 GO:0052202 biolink:BiologicalProcess obsolete negative regulation by symbiont of defense-related host cell wall callose deposition OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of defense-related host cell wall callose deposition|down-regulation by symbiont of defense-related host cell wall callose deposition|downregulation by symbiont of defense-related host cell wall callose deposition|inhibition by symbiont of defense-related host cell wall callose deposition|negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction|negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction|negative regulation by symbiont of defense-related host callose deposition True http://purl.obolibrary.org/obo/GO_0052202 GO:0160113 biolink:CellularComponent axonemal microtubule doublet inner junction The structure which joins the B10 protofilament of the B tubule to the A1 protofilament of the A tubule within an axonemal microtubule doublet. go.json http://purl.obolibrary.org/obo/GO_0160113 GO:0052209 biolink:BiologicalProcess obsolete interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction. go.json interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052209 GO:0052208 biolink:BiologicalProcess obsolete modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction. go.json modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052208 GO:0160112 biolink:CellularComponent axonemal B tubule inner sheath A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule. go.json http://purl.obolibrary.org/obo/GO_0160112 GO:0160115 biolink:CellularComponent axonemal microtubule doublet ribbon The 3 protofilaments A11, A12, and A13 of the A tubule along with associated inner sheath microtuble inner proteins (MIPs), either in the lumen of the A tubule or of the B tubule, which stabilize these three filiments within the axonemal doublet microtubule. The ribbon protofilaments separate the lumens of the A and B tubules. go.json http://purl.obolibrary.org/obo/GO_0160115 GO:0052207 biolink:BiologicalProcess obsolete modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction. go.json modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052207 GO:0160114 biolink:CellularComponent axonemal microtubule doublet outer junction The structure which joins the B1 protofilament of the B tubule to the A10 and A11 protofilaments of the A tubule within an axonemal microtubule doublet. go.json http://purl.obolibrary.org/obo/GO_0160114 GO:0052206 biolink:BiologicalProcess obsolete modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction. go.json modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052206 GO:0042882 biolink:BiologicalProcess L-arabinose transmembrane transport The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. go.json L-arabinose transport http://purl.obolibrary.org/obo/GO_0042882 GO:0042881 biolink:MolecularActivity D-galactonate transmembrane transporter activity Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042881 GO:0042884 biolink:BiologicalProcess microcin transport The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042884 GO:0042883 biolink:BiologicalProcess cysteine transport The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json L-cysteine transport http://purl.obolibrary.org/obo/GO_0042883 GO:0042880 biolink:MolecularActivity D-glucuronate transmembrane transporter activity Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042880 GO:0042889 biolink:BiologicalProcess obsolete 3-phenylpropionic acid transport OBSOLETE. The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 3-phenylpropionate transport|HCA transport|hydrocinnamic acid transport True http://purl.obolibrary.org/obo/GO_0042889 GO:0042886 biolink:BiologicalProcess amide transport The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042886 goslim_pir GO:0042885 biolink:BiologicalProcess microcin B17 transport The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042885 GO:0042888 biolink:MolecularActivity molybdenum ion transmembrane transporter activity Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042888 GO:0042887 biolink:MolecularActivity amide transmembrane transporter activity Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. go.json amine/amide/polyamine channel activity http://purl.obolibrary.org/obo/GO_0042887 GO:0160111 biolink:CellularComponent axonemal A tubule inner sheath A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule. go.json http://purl.obolibrary.org/obo/GO_0160111 GO:0160110 biolink:CellularComponent axonemal microtubule doublet inner sheath A structural network of microtubule inner proteins (MIPs) located inside the lumens of the A and B tubules of the axonemal microtuble doublet that helps stabilize the doublet microtubule. go.json http://purl.obolibrary.org/obo/GO_0160110 GO:0052201 biolink:BiologicalProcess response to symbiont defenses Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0052201 GO:0052200 biolink:BiologicalProcess response to host defenses Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json maintenance of symbiont tolerance to host defense molecules|response of symbiont to host defense molecules|response to host defense molecules http://purl.obolibrary.org/obo/GO_0052200 GO:0052216 biolink:BiologicalProcess obsolete chemotaxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json chemotaxis in environment of other organism during symbiotic interaction|chemotaxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052216 GO:0052215 biolink:BiologicalProcess obsolete energy taxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json energy taxis in environment of other organism during symbiotic interaction|energy taxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052215 GO:0052214 biolink:BiologicalProcess obsolete metabolism of substance in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism of substance in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052214 GO:0052213 biolink:BiologicalProcess obsolete interaction with symbiont via secreted substance OBSOLETE. An interaction with a symbiont organism mediated by a substance secreted by a host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json interaction with symbiont via secreted substance during symbiotic interaction|interaction with symbiont via secreted substance involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052213 GO:0052219 biolink:BiologicalProcess obsolete negative energy taxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json negative energy taxis in environment of other organism during symbiotic interaction|negative energy taxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052219 GO:0052218 biolink:BiologicalProcess obsolete positive energy taxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json positive energy taxis in environment of other organism during symbiotic interaction|positive energy taxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052218 GO:0052217 biolink:BiologicalProcess obsolete aerotaxis in environment of other organism involved in symbiotic interaction OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json aerotaxis in environment of other organism during symbiotic interaction|aerotaxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052217 GO:0042893 biolink:BiologicalProcess polymyxin transport The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042893 GO:0042892 biolink:BiologicalProcess chloramphenicol transmembrane transport The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other. go.json chloramphenicol transport http://purl.obolibrary.org/obo/GO_0042892 GO:0042895 biolink:MolecularActivity obsolete antibiotic transmembrane transporter activity OBSOLETE. Enables the transfer of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, from one side of a membrane to the other. go.json antibiotic transporter activity True http://purl.obolibrary.org/obo/GO_0042895 GO:0042894 biolink:BiologicalProcess fosmidomycin transport The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042894 GO:0042891 biolink:BiologicalProcess obsolete antibiotic transport OBSOLETE. The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json True http://purl.obolibrary.org/obo/GO_0042891 GO:0042890 biolink:MolecularActivity obsolete 3-phenylpropionic acid transmembrane transporter activity OBSOLETE. Enables the transfer of 3-phenylpropionic acid from one side of a membrane to the other. go.json 3-phenylpropionate acid transporter activity|HCA transporter activity|hydrocinnamic acid transporter activity True http://purl.obolibrary.org/obo/GO_0042890 GO:0042897 biolink:MolecularActivity polymyxin transmembrane transporter activity Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other. go.json polymyxin transporter activity http://purl.obolibrary.org/obo/GO_0042897 GO:0042896 biolink:MolecularActivity chloramphenicol transmembrane transporter activity Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other. go.json chloramphenicol transporter activity http://purl.obolibrary.org/obo/GO_0042896 GO:0042899 biolink:BiologicalProcess arabinan transmembrane transport The process in which arabinan is transported across a lipid bilayer, from one side of a membrane to the other. go.json arabinan transport http://purl.obolibrary.org/obo/GO_0042899 GO:0042898 biolink:MolecularActivity fosmidomycin transmembrane transporter activity Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other. go.json fosmidomycin transporter activity http://purl.obolibrary.org/obo/GO_0042898 GO:0052212 biolink:BiologicalProcess obsolete modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction. go.json modification of host morphology or physiology via effector molecule|modification of host morphology or physiology via ellicitor|modification of morphology or physiology of other organism via secreted substance during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052212 GO:0052211 biolink:BiologicalProcess obsolete interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction. go.json interaction with other organism via protein secreted by type II secretion system during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052211 GO:0052210 biolink:BiologicalProcess obsolete interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction. go.json interaction with other organism via protein secreted by type III secretion system during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052210 GO:0052227 biolink:BiologicalProcess obsolete catabolism of substance in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction. go.json catabolism of substance in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052227 GO:0052226 biolink:BiologicalProcess obsolete biosynthesis of substance in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction. go.json biosynthesis of substance in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052226 GO:0052225 biolink:BiologicalProcess obsolete energy taxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json energy taxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052225 GO:0052224 biolink:BiologicalProcess obsolete energy taxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json energy taxis in other organism during symbiotic interaction|energy taxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052224 GO:0052229 biolink:BiologicalProcess obsolete metabolism of macromolecule in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism of macromolecule in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052229 GO:0052228 biolink:BiologicalProcess obsolete metabolism by symbiont of host protein OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052228 GO:0052223 biolink:BiologicalProcess obsolete negative chemotaxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json negative chemotaxis in environment of other organism during symbiotic interaction|negative chemotaxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052223 GO:0052222 biolink:BiologicalProcess obsolete negative aerotaxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json negative aerotaxis in environment of other organism during symbiotic interaction|negative aerotaxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052222 GO:0052221 biolink:BiologicalProcess obsolete positive chemotaxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json positive chemotaxis in environment of other organism during symbiotic interaction|positive chemotaxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052221 GO:0052220 biolink:BiologicalProcess obsolete positive aerotaxis in environment of other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction. go.json positive aerotaxis in environment of other organism during symbiotic interaction|positive aerotaxis in response to environment of other organism True http://purl.obolibrary.org/obo/GO_0052220 GO:0052238 biolink:BiologicalProcess obsolete aerotaxis on or near other organism involved in symbiotic interaction OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction. go.json aerotaxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052238 GO:0160106 biolink:MolecularActivity tRNA (adenine(9)-N1)-methyltransferase activity Catalysis of the reaction: adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.218|RHEA:43148 go.json tRNA (adenine(9)-N(1))-methyltransferase activity|tRNA m(1)A(9)-methyltransferase|tRNA(m(1)G(9)/m(1)A(9))-methyltransferase http://purl.obolibrary.org/obo/GO_0160106 GO:0052237 biolink:BiologicalProcess obsolete aerotaxis in other organism involved in symbiotic interaction OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction. go.json aerotaxis in other organism during symbiotic interaction|aerotaxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052237 GO:0160105 biolink:MolecularActivity tRNA (adenine(22)-N1)-methyltransferase activity Catalysis of the reaction: adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.217|RHEA:43144 go.json tRNA (adenine(22)-N(1))-methyltransferase activity|tRNA (adenosine(22)-N(1))-methyltransferase activity http://purl.obolibrary.org/obo/GO_0160105 GO:0052236 biolink:BiologicalProcess obsolete negative chemotaxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction. go.json negative chemotaxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052236 GO:0160108 biolink:BiologicalProcess animal gross anatomical part developmental process Any developmental process whose specific outcome is the progression of a gross anatomical part of an animal from an initial immature state, to a later, more mature state. go.json animal development http://purl.obolibrary.org/obo/GO_0160108 GO:0160107 biolink:MolecularActivity tRNA (adenine(58)-N1)-methyltransferase activity Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.220|RHEA:43152 go.json tRNA (adenine(58)-N(1))-methyltransferase activity|tRNA (m(1)A(58)) methyltransferase|tRNA m(1)A(58) methyltransferase http://purl.obolibrary.org/obo/GO_0160107 GO:0052235 biolink:BiologicalProcess obsolete negative aerotaxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction. go.json negative aerotaxis in other organism during symbiotic interaction|negative aerotaxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052235 GO:0160102 biolink:MolecularActivity tRNA (guanine(10)-N2)-methyltransferase activity Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine. EC:2.1.1.214|RHEA:43128 go.json tRNA (guanine(10)-N(2))-methyltransferase activity|tRNA (guanosine(10)-N(2))-methyltransferase activity http://purl.obolibrary.org/obo/GO_0160102 GO:0160101 biolink:MolecularActivity tRNA (guanine(10)-N2)-dimethyltransferase activity Catalysis of the reaction: guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine. EC:2.1.1.213|RHEA:43124 go.json N(2),N(2)-dimethylguanosine tRNA methyltransferase|tRNA (guanine(10)-N(2))-dimethyltransferase activity|tRNA (guanosine(10)-N(2))-dimethyltransferase activity http://purl.obolibrary.org/obo/GO_0160101 GO:0160104 biolink:MolecularActivity tRNA (guanine(26)-N2)-dimethyltransferase activity Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine. EC:2.1.1.216|RHEA:43140 go.json tRNA (guanine(26)-N(2))-dimethyltransferase activity|tRNA (guanosine(26)-N(2))-dimethyltransferase activity|tRNA (m(2)2G26)dimethyltransferase http://purl.obolibrary.org/obo/GO_0160104 GO:0052239 biolink:BiologicalProcess obsolete negative chemotaxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction. go.json negative chemotaxis in other organism during symbiotic interaction|negative chemotaxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052239 GO:0160103 biolink:MolecularActivity tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity Catalysis of the reaction: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine. EC:2.1.1.215|RHEA:43136 go.json tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase activity|tRNA (guanosine(26)-N(2)/guanosine(27)-N(2))-dimethyltransferase activity http://purl.obolibrary.org/obo/GO_0160103 GO:0160109 biolink:BiologicalProcess plant gross anatomical part developmental process Any developmental process whose specific outcome is the progression of a gross anatomical part of a plant from an initial immature state, to a later, more mature state. go.json plant development http://purl.obolibrary.org/obo/GO_0160109 GO:0052230 biolink:BiologicalProcess obsolete modulation of intracellular transport in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of intracellular trafficking in other organism|modulation of intracellular transport in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052230 GO:0052234 biolink:BiologicalProcess obsolete negative aerotaxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction. go.json negative aerotaxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052234 GO:0052233 biolink:BiologicalProcess obsolete positive aerotaxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction. go.json positive aerotaxis in other organism during symbiotic interaction|positive aerotaxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052233 GO:0052232 biolink:BiologicalProcess obsolete positive aerotaxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction. go.json positive aerotaxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052232 GO:0052231 biolink:BiologicalProcess obsolete modulation of phagocytosis in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of phagocytosis in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052231 GO:0052249 biolink:BiologicalProcess obsolete modulation of RNA levels in other organism involved in symbiotic interaction OBSOLETE. The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of RNA levels in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052249 GO:0052248 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052248 GO:0052247 biolink:BiologicalProcess obsolete positive energy taxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json positive energy taxis in other organism during symbiotic interaction|positive energy taxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052247 GO:0052246 biolink:BiologicalProcess obsolete positive energy taxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json positive energy taxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052246 GO:1904002 biolink:BiologicalProcess regulation of sebum secreting cell proliferation Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation. go.json regulation of sebocyte proliferation http://purl.obolibrary.org/obo/GO_1904002 GO:1904001 biolink:BiologicalProcess obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage. go.json activation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter|activation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter|positive regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter|up regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter|up regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter|up-regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter|up-regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter|upregulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter|upregulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1904001 GO:1904000 biolink:BiologicalProcess positive regulation of eating behavior Any process that activates or increases the frequency, rate or extent of eating behavior. go.json activation of eating behavior|activation of eating behaviour|positive regulation of eating behaviour|up regulation of eating behavior|up regulation of eating behaviour|up-regulation of eating behavior|up-regulation of eating behaviour|upregulation of eating behavior|upregulation of eating behaviour http://purl.obolibrary.org/obo/GO_1904000 GO:0052241 biolink:BiologicalProcess obsolete positive chemotaxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction. go.json positive chemotaxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052241 GO:0052240 biolink:BiologicalProcess obsolete positive chemotaxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction. go.json positive chemotaxis in other organism during symbiotic interaction|positive chemotaxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052240 GO:0052245 biolink:BiologicalProcess obsolete negative energy taxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json negative energy taxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052245 GO:0052244 biolink:BiologicalProcess obsolete negative energy taxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. go.json negative energy taxis in other organism during symbiotic interaction|negative energy taxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052244 GO:0052243 biolink:BiologicalProcess obsolete chemotaxis on or near other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction. go.json chemotaxis on or near other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052243 GO:0052242 biolink:BiologicalProcess obsolete chemotaxis in other organism involved in symbiotic interaction OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction. go.json chemotaxis in other organism during symbiotic interaction|chemotaxis within other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052242 GO:0052259 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052259 GO:0052258 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052258 GO:0052257 biolink:BiologicalProcess obsolete pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction. go.json MAMP dependent induction of innate immunity of other organism|MAMP-dependent induction of innate immunity of other organism|PAMP dependent induction of innate immunity of other organism|PAMP-dependent induction of innate immunity of other organism|general elicitor dependent induction of innate immunity of other organism|general elicitor-dependent induction of innate immunity of other organism|pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction|pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052257 GO:1904009 biolink:BiologicalProcess obsolete cellular response to monosodium glutamate OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904009 GO:1904008 biolink:BiologicalProcess obsolete response to monosodium glutamate OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904008 GO:1904007 biolink:BiologicalProcess positive regulation of phospholipase D activity Any process that activates or increases the frequency, rate or extent of phospholipase D activity. go.json activation of choline phosphatase activity|activation of lecithinase D activity|activation of lipophosphodiesterase II activity|activation of phosphatidylcholine phosphatidohydrolase activity|activation of phospholipase D activity|positive regulation of choline phosphatase activity|positive regulation of lecithinase D activity|positive regulation of lipophosphodiesterase II activity|positive regulation of phosphatidylcholine phosphatidohydrolase activity|up regulation of choline phosphatase activity|up regulation of lecithinase D activity|up regulation of lipophosphodiesterase II activity|up regulation of phosphatidylcholine phosphatidohydrolase activity|up regulation of phospholipase D activity|up-regulation of choline phosphatase activity|up-regulation of lecithinase D activity|up-regulation of lipophosphodiesterase II activity|up-regulation of phosphatidylcholine phosphatidohydrolase activity|up-regulation of phospholipase D activity|upregulation of choline phosphatase activity|upregulation of lecithinase D activity|upregulation of lipophosphodiesterase II activity|upregulation of phosphatidylcholine phosphatidohydrolase activity|upregulation of phospholipase D activity http://purl.obolibrary.org/obo/GO_1904007 gocheck_do_not_annotate GO:1904006 biolink:BiologicalProcess negative regulation of phospholipase D activity Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity. go.json down regulation of choline phosphatase activity|down regulation of lecithinase D activity|down regulation of lipophosphodiesterase II activity|down regulation of phosphatidylcholine phosphatidohydrolase activity|down regulation of phospholipase D activity|down-regulation of choline phosphatase activity|down-regulation of lecithinase D activity|down-regulation of lipophosphodiesterase II activity|down-regulation of phosphatidylcholine phosphatidohydrolase activity|down-regulation of phospholipase D activity|downregulation of choline phosphatase activity|downregulation of lecithinase D activity|downregulation of lipophosphodiesterase II activity|downregulation of phosphatidylcholine phosphatidohydrolase activity|downregulation of phospholipase D activity|inhibition of choline phosphatase activity|inhibition of lecithinase D activity|inhibition of lipophosphodiesterase II activity|inhibition of phosphatidylcholine phosphatidohydrolase activity|inhibition of phospholipase D activity|negative regulation of choline phosphatase activity|negative regulation of lecithinase D activity|negative regulation of lipophosphodiesterase II activity|negative regulation of phosphatidylcholine phosphatidohydrolase activity http://purl.obolibrary.org/obo/GO_1904006 gocheck_do_not_annotate GO:1904005 biolink:BiologicalProcess regulation of phospholipase D activity Any process that modulates the frequency, rate or extent of phospholipase D activity. go.json regulation of choline phosphatase activity|regulation of lecithinase D activity|regulation of lipophosphodiesterase II activity|regulation of phosphatidylcholine phosphatidohydrolase activity http://purl.obolibrary.org/obo/GO_1904005 gocheck_do_not_annotate GO:1904004 biolink:BiologicalProcess positive regulation of sebum secreting cell proliferation Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation. go.json activation of sebocyte proliferation|activation of sebum secreting cell proliferation|positive regulation of sebocyte proliferation|up regulation of sebocyte proliferation|up regulation of sebum secreting cell proliferation|up-regulation of sebocyte proliferation|up-regulation of sebum secreting cell proliferation|upregulation of sebocyte proliferation|upregulation of sebum secreting cell proliferation http://purl.obolibrary.org/obo/GO_1904004 GO:1904003 biolink:BiologicalProcess negative regulation of sebum secreting cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation. go.json down regulation of sebocyte proliferation|down regulation of sebum secreting cell proliferation|down-regulation of sebocyte proliferation|down-regulation of sebum secreting cell proliferation|downregulation of sebocyte proliferation|downregulation of sebum secreting cell proliferation|inhibition of sebocyte proliferation|inhibition of sebum secreting cell proliferation|negative regulation of sebocyte proliferation http://purl.obolibrary.org/obo/GO_1904003 GO:1904013 biolink:MolecularActivity obsolete xenon atom binding OBSOLETE. Binding to xenon atom. go.json True http://purl.obolibrary.org/obo/GO_1904013 GO:1904012 biolink:MolecularActivity obsolete platinum binding OBSOLETE. Binding to platinum. go.json True http://purl.obolibrary.org/obo/GO_1904012 GO:1904011 biolink:BiologicalProcess cellular response to Aroclor 1254 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus. go.json http://purl.obolibrary.org/obo/GO_1904011 GO:1904010 biolink:BiologicalProcess response to Aroclor 1254 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus. go.json http://purl.obolibrary.org/obo/GO_1904010 GO:0052252 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052252 GO:0052251 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052251 GO:0052250 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052250 GO:0052256 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052256 GO:0052255 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052255 GO:0052254 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052254 GO:0052253 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052253 GO:0052269 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052269 GO:0052268 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052268 GO:1904019 biolink:BiologicalProcess epithelial cell apoptotic process Any apoptotic process in an epithelial cell. go.json epithelial cell apoptosis|epitheliocyte apoptosis|epitheliocyte apoptotic process http://purl.obolibrary.org/obo/GO_1904019 GO:1904018 biolink:BiologicalProcess positive regulation of vasculature development Any process that activates or increases the frequency, rate or extent of vasculature development. go.json activation of vascular system development|activation of vasculature development|positive regulation of vascular system development|up regulation of vascular system development|up regulation of vasculature development|up-regulation of vascular system development|up-regulation of vasculature development|upregulation of vascular system development|upregulation of vasculature development http://purl.obolibrary.org/obo/GO_1904018 GO:1904017 biolink:BiologicalProcess cellular response to Thyroglobulin triiodothyronine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904017 GO:1904016 biolink:BiologicalProcess response to Thyroglobulin triiodothyronine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904016 GO:1904015 biolink:BiologicalProcess cellular response to serotonin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904015 GO:1904014 biolink:BiologicalProcess response to serotonin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904014 GO:1904024 biolink:BiologicalProcess negative regulation of glucose catabolic process to lactate via pyruvate Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. go.json down regulation of glucose catabolic process to lactate via pyruvate|down regulation of glucose fermentation to lactate via pyruvate|down regulation of homofermentation|down regulation of homofermentative lactate fermentation|down regulation of homofermentative pathway|down regulation of homolactate fermentation|down regulation of homolactic fermentation|down-regulation of glucose catabolic process to lactate via pyruvate|down-regulation of glucose fermentation to lactate via pyruvate|down-regulation of homofermentation|down-regulation of homofermentative lactate fermentation|down-regulation of homofermentative pathway|down-regulation of homolactate fermentation|down-regulation of homolactic fermentation|downregulation of glucose catabolic process to lactate via pyruvate|downregulation of glucose fermentation to lactate via pyruvate|downregulation of homofermentation|downregulation of homofermentative lactate fermentation|downregulation of homofermentative pathway|downregulation of homolactate fermentation|downregulation of homolactic fermentation|inhibition of glucose catabolic process to lactate via pyruvate|inhibition of glucose fermentation to lactate via pyruvate|inhibition of homofermentation|inhibition of homofermentative lactate fermentation|inhibition of homofermentative pathway|inhibition of homolactate fermentation|inhibition of homolactic fermentation|negative regulation of glucose fermentation to lactate via pyruvate|negative regulation of homofermentation|negative regulation of homofermentative lactate fermentation|negative regulation of homofermentative pathway|negative regulation of homolactate fermentation|negative regulation of homolactic fermentation http://purl.obolibrary.org/obo/GO_1904024 GO:1904023 biolink:BiologicalProcess regulation of glucose catabolic process to lactate via pyruvate Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. go.json regulation of glucose fermentation to lactate via pyruvate|regulation of homofermentation|regulation of homofermentative lactate fermentation|regulation of homofermentative pathway|regulation of homolactate fermentation|regulation of homolactic fermentation http://purl.obolibrary.org/obo/GO_1904023 GO:1904022 biolink:BiologicalProcess positive regulation of G protein-coupled receptor internalization Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor internalization. go.json activation of G-protein coupled receptor internalization|positive regulation of G-protein coupled receptor internalization|up regulation of G-protein coupled receptor internalization|up-regulation of G-protein coupled receptor internalization|upregulation of G-protein coupled receptor internalization http://purl.obolibrary.org/obo/GO_1904022 GO:1904021 biolink:BiologicalProcess negative regulation of G protein-coupled receptor internalization Any process that stops, prevents or reduces the frequency, rate or extent of G protein-coupled receptor internalization. go.json down regulation of G-protein coupled receptor internalization|down-regulation of G-protein coupled receptor internalization|downregulation of G-protein coupled receptor internalization|inhibition of G-protein coupled receptor internalization|negative regulation of G-protein coupled receptor internalization http://purl.obolibrary.org/obo/GO_1904021 GO:1904020 biolink:BiologicalProcess regulation of G protein-coupled receptor internalization Any process that modulates the frequency, rate or extent of G protein-coupled receptor internalization. go.json regulation of G-protein-coupled receptor internalization http://purl.obolibrary.org/obo/GO_1904020 GO:0052263 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052263 GO:0052262 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052262 GO:0052261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052261 GO:0052260 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052260 GO:0052267 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052267 GO:0052266 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052266 GO:0052265 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052265 GO:0052264 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052264 GO:0052279 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052279 GO:1904029 biolink:BiologicalProcess regulation of cyclin-dependent protein kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. go.json http://purl.obolibrary.org/obo/GO_1904029 gocheck_do_not_annotate GO:1904028 biolink:BiologicalProcess positive regulation of collagen fibril organization Any process that activates or increases the frequency, rate or extent of collagen fibril organization. go.json activation of collagen fibril organisation|activation of collagen fibril organization|activation of fibrillar collagen organization|positive regulation of collagen fibril organisation|positive regulation of fibrillar collagen organization|up regulation of collagen fibril organisation|up regulation of collagen fibril organization|up regulation of fibrillar collagen organization|up-regulation of collagen fibril organisation|up-regulation of collagen fibril organization|up-regulation of fibrillar collagen organization|upregulation of collagen fibril organisation|upregulation of collagen fibril organization|upregulation of fibrillar collagen organization http://purl.obolibrary.org/obo/GO_1904028 GO:1904027 biolink:BiologicalProcess negative regulation of collagen fibril organization Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. go.json down regulation of collagen fibril organisation|down regulation of collagen fibril organization|down regulation of fibrillar collagen organization|down-regulation of collagen fibril organisation|down-regulation of collagen fibril organization|down-regulation of fibrillar collagen organization|downregulation of collagen fibril organisation|downregulation of collagen fibril organization|downregulation of fibrillar collagen organization|inhibition of collagen fibril organisation|inhibition of collagen fibril organization|inhibition of fibrillar collagen organization|negative regulation of collagen fibril organisation|negative regulation of fibrillar collagen organization http://purl.obolibrary.org/obo/GO_1904027 GO:1904026 biolink:BiologicalProcess regulation of collagen fibril organization Any process that modulates the frequency, rate or extent of collagen fibril organization. go.json regulation of collagen fibril organisation|regulation of collagen fibrillogenesis|regulation of fibrillar collagen organization http://purl.obolibrary.org/obo/GO_1904026 GO:1904025 biolink:BiologicalProcess positive regulation of glucose catabolic process to lactate via pyruvate Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. go.json activation of glucose catabolic process to lactate via pyruvate|activation of glucose fermentation to lactate via pyruvate|activation of homofermentation|activation of homofermentative lactate fermentation|activation of homofermentative pathway|activation of homolactate fermentation|activation of homolactic fermentation|positive regulation of glucose fermentation to lactate via pyruvate|positive regulation of homofermentation|positive regulation of homofermentative lactate fermentation|positive regulation of homofermentative pathway|positive regulation of homolactate fermentation|positive regulation of homolactic fermentation|up regulation of glucose catabolic process to lactate via pyruvate|up regulation of glucose fermentation to lactate via pyruvate|up regulation of homofermentation|up regulation of homofermentative lactate fermentation|up regulation of homofermentative pathway|up regulation of homolactate fermentation|up regulation of homolactic fermentation|up-regulation of glucose catabolic process to lactate via pyruvate|up-regulation of glucose fermentation to lactate via pyruvate|up-regulation of homofermentation|up-regulation of homofermentative lactate fermentation|up-regulation of homofermentative pathway|up-regulation of homolactate fermentation|up-regulation of homolactic fermentation|upregulation of glucose catabolic process to lactate via pyruvate|upregulation of glucose fermentation to lactate via pyruvate|upregulation of homofermentation|upregulation of homofermentative lactate fermentation|upregulation of homofermentative pathway|upregulation of homolactate fermentation|upregulation of homolactic fermentation http://purl.obolibrary.org/obo/GO_1904025 GO:1904035 biolink:BiologicalProcess regulation of epithelial cell apoptotic process Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. go.json regulation of epithelial cell apoptosis|regulation of epitheliocyte apoptosis|regulation of epitheliocyte apoptotic process http://purl.obolibrary.org/obo/GO_1904035 GO:1904034 biolink:BiologicalProcess positive regulation of t-SNARE clustering Any process that activates or increases the frequency, rate or extent of t-SNARE clustering. go.json activation of t-SNARE clustering|up regulation of t-SNARE clustering|up-regulation of t-SNARE clustering|upregulation of t-SNARE clustering http://purl.obolibrary.org/obo/GO_1904034 GO:1904033 biolink:BiologicalProcess negative regulation of t-SNARE clustering Any process that stops, prevents or reduces the frequency, rate or extent of t-SNARE clustering. go.json down regulation of t-SNARE clustering|down-regulation of t-SNARE clustering|downregulation of t-SNARE clustering|inhibition of t-SNARE clustering http://purl.obolibrary.org/obo/GO_1904033 GO:1904032 biolink:BiologicalProcess regulation of t-SNARE clustering Any process that modulates the frequency, rate or extent of t-SNARE clustering. go.json http://purl.obolibrary.org/obo/GO_1904032 GO:1904031 biolink:BiologicalProcess positive regulation of cyclin-dependent protein kinase activity Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. go.json activation of cyclin-dependent protein kinase activity|up regulation of cyclin-dependent protein kinase activity|up-regulation of cyclin-dependent protein kinase activity|upregulation of cyclin-dependent protein kinase activity http://purl.obolibrary.org/obo/GO_1904031 gocheck_do_not_annotate GO:0052270 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052270 GO:1904030 biolink:BiologicalProcess negative regulation of cyclin-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. go.json down regulation of cyclin-dependent protein kinase activity|down-regulation of cyclin-dependent protein kinase activity|downregulation of cyclin-dependent protein kinase activity|inhibition of cyclin-dependent protein kinase activity http://purl.obolibrary.org/obo/GO_1904030 gocheck_do_not_annotate GO:0052274 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052274 GO:0052273 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052273 GO:0052272 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052272 GO:0052271 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052271 GO:0052278 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052278 GO:0052277 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052277 GO:0052276 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052276 GO:0052275 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052275 GO:0042802 biolink:MolecularActivity identical protein binding Binding to an identical protein or proteins. go.json isoform-specific homophilic binding|protein homopolymerization http://purl.obolibrary.org/obo/GO_0042802 goslim_chembl GO:0042801 biolink:MolecularActivity obsolete polo kinase kinase activity OBSOLETE. Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins. go.json True http://purl.obolibrary.org/obo/GO_0042801 GO:0042804 biolink:MolecularActivity obsolete protein homooligomerization activity OBSOLETE. Interacting selectively with identical proteins to form a homooligomer. go.json oligomerization activity|protein homooligomerization activity True http://purl.obolibrary.org/obo/GO_0042804 GO:0042803 biolink:MolecularActivity protein homodimerization activity Binding to an identical protein to form a homodimer. go.json dimerization activity http://purl.obolibrary.org/obo/GO_0042803 goslim_chembl GO:0042800 biolink:MolecularActivity histone H3K4 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein. Reactome:R-HSA-1214188|Reactome:R-HSA-3364026|Reactome:R-HSA-8865498|Reactome:R-HSA-8936481|Reactome:R-HSA-8936621|Reactome:R-HSA-8937016|Reactome:R-HSA-8937050 go.json histone H3 lysine 4-specific methyltransferase activity|histone H3K4 methylase activity|histone lysine N-methyltransferase activity (H3-K4 specific)|histone methylase activity (H3-K4 specific)|histone methyltransferase activity (H3-K4 specific)|histone-H3K4 methyltransferase activity http://purl.obolibrary.org/obo/GO_0042800 GO:0042809 biolink:MolecularActivity nuclear vitamin D receptor binding Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. go.json VDR binding|calciferol receptor binding|vitamin D receptor binding http://purl.obolibrary.org/obo/GO_0042809 GO:0042806 biolink:MolecularActivity fucose binding Binding to fucose, the pentose 6-deoxygalactose. go.json http://purl.obolibrary.org/obo/GO_0042806 GO:0042805 biolink:MolecularActivity actinin binding Binding to actinin, any member of a family of proteins that crosslink F-actin. go.json beta-actinin binding|capZ binding http://purl.obolibrary.org/obo/GO_0042805 GO:0042808 biolink:MolecularActivity obsolete neuronal Cdc2-like kinase binding OBSOLETE. Binding to neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics. go.json neuronal Cdc2-like kinase binding True http://purl.obolibrary.org/obo/GO_0042808 GO:0042807 biolink:CellularComponent central vacuole A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination. go.json http://purl.obolibrary.org/obo/GO_0042807 GO:0003205 biolink:BiologicalProcess cardiac chamber development The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. go.json http://purl.obolibrary.org/obo/GO_0003205 GO:0003204 biolink:BiologicalProcess cardiac skeleton development The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. go.json heart fibrous skeleton development http://purl.obolibrary.org/obo/GO_0003204 GO:0003207 biolink:BiologicalProcess cardiac chamber formation The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. go.json heart chamber formation http://purl.obolibrary.org/obo/GO_0003207 GO:0003206 biolink:BiologicalProcess cardiac chamber morphogenesis The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. go.json heart chamber morphogenesis http://purl.obolibrary.org/obo/GO_0003206 GO:0003201 biolink:BiologicalProcess epithelial to mesenchymal transition involved in coronary vasculature morphogenesis A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature. go.json http://purl.obolibrary.org/obo/GO_0003201 GO:0003200 biolink:BiologicalProcess endocardial cushion to mesenchymal transition involved in heart chamber septation A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum. go.json http://purl.obolibrary.org/obo/GO_0003200 GO:0003203 biolink:BiologicalProcess endocardial cushion morphogenesis The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. go.json http://purl.obolibrary.org/obo/GO_0003203 GO:0003202 biolink:BiologicalProcess endocardial cushion to mesenchymal transition involved in cardiac skeleton development A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton. go.json http://purl.obolibrary.org/obo/GO_0003202 GO:0042813 biolink:MolecularActivity Wnt receptor activity Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. go.json Wnt-activated receptor activity|frizzled receptor activity|frizzled-2 receptor activity http://purl.obolibrary.org/obo/GO_0042813 goslim_chembl GO:0042812 biolink:BiologicalProcess pheromone catabolic process The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. go.json pheromone breakdown|pheromone catabolism|pheromone degradation http://purl.obolibrary.org/obo/GO_0042812 GO:0042815 biolink:BiologicalProcess bipolar cell growth The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell. go.json bipolar cell elongation|bipolar growth|polar cell elongation http://purl.obolibrary.org/obo/GO_0042815 GO:0042814 biolink:BiologicalProcess monopolar cell growth Polarized growth from one end of a cell. go.json monopolar cell elongation|monopolar growth|polar cell elongation http://purl.obolibrary.org/obo/GO_0042814 GO:0042811 biolink:BiologicalProcess pheromone biosynthetic process The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. go.json pheromone anabolism|pheromone biosynthesis|pheromone formation|pheromone synthesis http://purl.obolibrary.org/obo/GO_0042811 GO:0042810 biolink:BiologicalProcess pheromone metabolic process The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. go.json pheromone metabolism http://purl.obolibrary.org/obo/GO_0042810 goslim_pir GO:0003209 biolink:BiologicalProcess cardiac atrium morphogenesis The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. go.json http://purl.obolibrary.org/obo/GO_0003209 GO:0042817 biolink:BiologicalProcess pyridoxal metabolic process The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json pyridoxal metabolism http://purl.obolibrary.org/obo/GO_0042817 GO:0003208 biolink:BiologicalProcess cardiac ventricle morphogenesis The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. go.json http://purl.obolibrary.org/obo/GO_0003208 GO:0042816 biolink:BiologicalProcess vitamin B6 metabolic process The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. go.json vitamin B6 metabolism http://purl.obolibrary.org/obo/GO_0042816 GO:0042819 biolink:BiologicalProcess vitamin B6 biosynthetic process The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. go.json pyridoxine-5'-phosphate biosynthesis|vitamin B6 anabolism|vitamin B6 biosynthesis|vitamin B6 formation|vitamin B6 synthesis http://purl.obolibrary.org/obo/GO_0042819 GO:0042818 biolink:BiologicalProcess pyridoxamine metabolic process The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. go.json pyridoxamine metabolism http://purl.obolibrary.org/obo/GO_0042818 GO:0042824 biolink:CellularComponent MHC class I peptide loading complex A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. go.json PLC|peptide-loading complex http://purl.obolibrary.org/obo/GO_0042824 goslim_pir GO:0042823 biolink:BiologicalProcess pyridoxal phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. MetaCyc:PWY0-845 go.json active vitamin B6 biosynthesis|active vitamin B6 biosynthetic process|pyridoxal phosphate anabolism|pyridoxal phosphate biosynthesis|pyridoxal phosphate formation|pyridoxal phosphate synthesis http://purl.obolibrary.org/obo/GO_0042823 GO:0042826 biolink:MolecularActivity histone deacetylase binding Binding to histone deacetylase. go.json http://purl.obolibrary.org/obo/GO_0042826 GO:0042825 biolink:CellularComponent TAP complex A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum. go.json transporter associated with antigen presentation http://purl.obolibrary.org/obo/GO_0042825 GO:0042820 biolink:BiologicalProcess vitamin B6 catabolic process The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. go.json vitamin B6 breakdown|vitamin B6 catabolism|vitamin B6 degradation http://purl.obolibrary.org/obo/GO_0042820 GO:0042822 biolink:BiologicalProcess pyridoxal phosphate metabolic process The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. go.json active vitamin B6 metabolic process|active vitamin B6 metabolism|pyridoxal phosphate metabolism http://purl.obolibrary.org/obo/GO_0042822 GO:0042821 biolink:BiologicalProcess pyridoxal biosynthetic process The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. go.json pyridoxal anabolism|pyridoxal biosynthesis|pyridoxal formation|pyridoxal synthesis http://purl.obolibrary.org/obo/GO_0042821 GO:0042828 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042828 GO:0042827 biolink:CellularComponent platelet dense granule Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. go.json bull's eye body|platelet dense body http://purl.obolibrary.org/obo/GO_0042827 GO:0042829 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042829 GO:0042835 biolink:MolecularActivity BRE binding Binding to a BRE RNA element (Bruno response element). go.json http://purl.obolibrary.org/obo/GO_0042835 GO:0042834 biolink:MolecularActivity peptidoglycan binding Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. go.json http://purl.obolibrary.org/obo/GO_0042834 GO:0042837 biolink:BiologicalProcess D-glucarate biosynthetic process The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate. go.json D-glucarate anabolism|D-glucarate biosynthesis|D-glucarate formation|D-glucarate synthesis|saccharate biosynthesis|saccharate biosynthetic process http://purl.obolibrary.org/obo/GO_0042837 GO:0042836 biolink:BiologicalProcess D-glucarate metabolic process The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose. go.json D-glucarate metabolism|saccharate metabolic process|saccharate metabolism http://purl.obolibrary.org/obo/GO_0042836 GO:0042831 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042831 GO:0042830 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042830 GO:0042833 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042833 GO:0042832 biolink:BiologicalProcess defense response to protozoan Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism. go.json defence response to pathogenic protozoa|defence response to protozoa|defence response to protozoon|defense response to pathogenic protozoa|defense response to protozoa|defense response to protozoan, incompatible interaction|defense response to protozoon|resistance response to pathogenic protozoa|resistance response to pathogenic protozoan http://purl.obolibrary.org/obo/GO_0042832 GO:0042839 biolink:BiologicalProcess D-glucuronate metabolic process The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate. go.json D-glucuronate metabolism http://purl.obolibrary.org/obo/GO_0042839 GO:0042838 biolink:BiologicalProcess D-glucarate catabolic process The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate. go.json D-glucarate breakdown|D-glucarate catabolism|D-glucarate degradation|saccharate catabolic process|saccharate catabolism http://purl.obolibrary.org/obo/GO_0042838 GO:0042840 biolink:BiologicalProcess D-glucuronate catabolic process The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate. go.json D-glucuronate breakdown|D-glucuronate catabolism|D-glucuronate degradation http://purl.obolibrary.org/obo/GO_0042840 GO:0042846 biolink:BiologicalProcess glycol catabolic process The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. go.json dihydric alcohol catabolic process|dihydric alcohol catabolism|glycol breakdown|glycol catabolism|glycol degradation http://purl.obolibrary.org/obo/GO_0042846 GO:0042845 biolink:BiologicalProcess glycol biosynthetic process The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. go.json dihydric alcohol biosynthesis|dihydric alcohol biosynthetic process|glycol anabolism|glycol biosynthesis|glycol formation|glycol synthesis http://purl.obolibrary.org/obo/GO_0042845 GO:0042848 biolink:BiologicalProcess sorbose catabolic process The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. go.json sorbose breakdown|sorbose catabolism|sorbose degradation http://purl.obolibrary.org/obo/GO_0042848 GO:0042847 biolink:BiologicalProcess sorbose biosynthetic process The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. go.json sorbose anabolism|sorbose biosynthesis|sorbose formation|sorbose synthesis http://purl.obolibrary.org/obo/GO_0042847 GO:0042842 biolink:BiologicalProcess D-xylose biosynthetic process The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide. go.json D-xylose anabolism|D-xylose biosynthesis|D-xylose formation|D-xylose synthesis http://purl.obolibrary.org/obo/GO_0042842 GO:0042841 biolink:BiologicalProcess D-glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate. go.json D-glucuronate anabolism|D-glucuronate biosynthesis|D-glucuronate formation|D-glucuronate synthesis http://purl.obolibrary.org/obo/GO_0042841 GO:0042844 biolink:BiologicalProcess glycol metabolic process The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. go.json dihydric alcohol metabolic process|dihydric alcohol metabolism|glycol metabolism http://purl.obolibrary.org/obo/GO_0042844 GO:0042843 biolink:BiologicalProcess D-xylose catabolic process The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide. go.json D-xylose breakdown|D-xylose catabolism|D-xylose degradation http://purl.obolibrary.org/obo/GO_0042843 GO:0042849 biolink:BiologicalProcess L-sorbose biosynthetic process The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. go.json L-sorbose anabolism|L-sorbose biosynthesis|L-sorbose formation|L-sorbose synthesis http://purl.obolibrary.org/obo/GO_0042849 GO:0042851 biolink:BiologicalProcess L-alanine metabolic process The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. go.json L-alanine metabolism http://purl.obolibrary.org/obo/GO_0042851 GO:0042850 biolink:BiologicalProcess L-sorbose catabolic process The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. go.json L-sorbose breakdown|L-sorbose catabolism|L-sorbose degradation http://purl.obolibrary.org/obo/GO_0042850 GO:0042857 biolink:BiologicalProcess chrysobactin metabolic process The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). go.json chrysobactin metabolism http://purl.obolibrary.org/obo/GO_0042857 GO:0042856 biolink:BiologicalProcess eugenol catabolic process The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. go.json 4-allyl-2-methoxyphenol catabolic process|4-allyl-2-methoxyphenol catabolism|eugenic acid catabolic process|eugenic acid catabolism|eugenol breakdown|eugenol catabolism|eugenol degradation http://purl.obolibrary.org/obo/GO_0042856 GO:0042859 biolink:BiologicalProcess chrysobactin catabolic process The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). go.json chrysobactin breakdown|chrysobactin catabolism|chrysobactin degradation http://purl.obolibrary.org/obo/GO_0042859 GO:0042858 biolink:BiologicalProcess chrysobactin biosynthetic process The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). go.json chrysobactin anabolism|chrysobactin biosynthesis|chrysobactin biosynthetic process, peptide formation|chrysobactin biosynthetic process, peptide modification|chrysobactin formation|chrysobactin synthesis http://purl.obolibrary.org/obo/GO_0042858 GO:0042853 biolink:BiologicalProcess L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. go.json L-alanine breakdown|L-alanine catabolism|L-alanine degradation http://purl.obolibrary.org/obo/GO_0042853 GO:0042852 biolink:BiologicalProcess L-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. go.json L-alanine anabolism|L-alanine biosynthesis|L-alanine formation|L-alanine synthesis http://purl.obolibrary.org/obo/GO_0042852 GO:0042855 biolink:BiologicalProcess eugenol biosynthetic process The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. go.json 4-allyl-2-methoxyphenol biosynthesis|4-allyl-2-methoxyphenol biosynthetic process|eugenic acid biosynthesis|eugenic acid biosynthetic process|eugenol anabolism|eugenol biosynthesis|eugenol formation|eugenol synthesis http://purl.obolibrary.org/obo/GO_0042855 GO:0042854 biolink:BiologicalProcess eugenol metabolic process The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. go.json 4-allyl-2-methoxyphenol metabolic process|4-allyl-2-methoxyphenol metabolism|eugenic acid metabolic process|eugenic acid metabolism|eugenol metabolism http://purl.obolibrary.org/obo/GO_0042854 GO:0042860 biolink:BiologicalProcess achromobactin metabolic process The chemical reactions and pathways involving achromobactin, a citrate siderophore. go.json achromobactin metabolism http://purl.obolibrary.org/obo/GO_0042860 GO:0042862 biolink:BiologicalProcess achromobactin catabolic process The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore. go.json achromobactin breakdown|achromobactin catabolism|achromobactin degradation http://purl.obolibrary.org/obo/GO_0042862 GO:0042861 biolink:BiologicalProcess achromobactin biosynthetic process The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore. go.json achromobactin anabolism|achromobactin biosynthesis|achromobactin formation|achromobactin synthesis http://purl.obolibrary.org/obo/GO_0042861 GO:0042868 biolink:BiologicalProcess antisense RNA metabolic process The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis. go.json antisense RNA metabolism http://purl.obolibrary.org/obo/GO_0042868 GO:0042867 biolink:BiologicalProcess pyruvate catabolic process The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate. go.json pyruvate breakdown|pyruvate catabolism|pyruvate degradation http://purl.obolibrary.org/obo/GO_0042867 GO:0042869 biolink:BiologicalProcess aldarate transmembrane transport The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other. go.json aldarate transport http://purl.obolibrary.org/obo/GO_0042869 GO:0042864 biolink:BiologicalProcess pyochelin biosynthetic process The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). go.json pyochelin anabolism|pyochelin biosynthesis|pyochelin biosynthetic process, peptide formation|pyochelin biosynthetic process, peptide modification|pyochelin formation|pyochelin synthesis http://purl.obolibrary.org/obo/GO_0042864 GO:0042863 biolink:BiologicalProcess pyochelin metabolic process The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). go.json pyochelin metabolism http://purl.obolibrary.org/obo/GO_0042863 GO:0042866 biolink:BiologicalProcess pyruvate biosynthetic process The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. go.json pyruvate anabolism|pyruvate biosynthesis|pyruvate formation|pyruvate synthesis http://purl.obolibrary.org/obo/GO_0042866 GO:0042865 biolink:BiologicalProcess pyochelin catabolic process The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). go.json pyochelin breakdown|pyochelin catabolism|pyochelin degradation http://purl.obolibrary.org/obo/GO_0042865 GO:0042871 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042871 GO:0042870 biolink:BiologicalProcess D-glucarate transmembrane transport The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other. go.json D-glucarate transport http://purl.obolibrary.org/obo/GO_0042870 GO:0042873 biolink:BiologicalProcess aldonate transmembrane transport The process in which aldonate is transported across a lipid bilayer, from one side of a membrane to the other. go.json aldonate transport http://purl.obolibrary.org/obo/GO_0042873 GO:0042872 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042872 GO:0042879 biolink:MolecularActivity aldonate transmembrane transporter activity Enables the transfer of aldonate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042879 GO:0042878 biolink:MolecularActivity D-glucarate transmembrane transporter activity Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042878 GO:0042875 biolink:BiologicalProcess D-galactonate transmembrane transport The process in which D-galactonate, the D-enantiomer of galactonate, is transported across a lipid bilayer, from one side of a membrane to the other. go.json D-galactonate transport http://purl.obolibrary.org/obo/GO_0042875 GO:0042874 biolink:BiologicalProcess D-glucuronate transmembrane transport The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other. go.json D-glucuronate transport http://purl.obolibrary.org/obo/GO_0042874 GO:0042877 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042877 GO:0042876 biolink:MolecularActivity aldarate transmembrane transporter activity Enables the transfer of aldarate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042876 OIO:hasScope biolink:OntologyClass has_scope go.json http://www.geneontology.org/formats/oboInOwl#hasScope GO:0003278 biolink:BiologicalProcess apoptotic process involved in heart morphogenesis Any apoptotic process that contributes to the shaping of the heart. go.json apoptosis involved in heart morphogenesis http://purl.obolibrary.org/obo/GO_0003278 GO:0003277 biolink:BiologicalProcess apoptotic process involved in endocardial cushion morphogenesis Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. go.json apoptosis involved in endocardial cushion morphogenesis http://purl.obolibrary.org/obo/GO_0003277 GO:0003279 biolink:BiologicalProcess cardiac septum development The progression of a cardiac septum over time, from its initial formation to the mature structure. go.json heart septum development http://purl.obolibrary.org/obo/GO_0003279 GO:0003274 biolink:BiologicalProcess endocardial cushion fusion The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping. go.json http://purl.obolibrary.org/obo/GO_0003274 GO:0003273 biolink:BiologicalProcess cell migration involved in endocardial cushion formation The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. go.json http://purl.obolibrary.org/obo/GO_0003273 GO:0003276 biolink:BiologicalProcess apoptotic process involved in heart valve morphogenesis Any apoptotic process that contributes to the shaping of a heart valve. go.json apoptosis involved in heart valve morphogenesis http://purl.obolibrary.org/obo/GO_0003276 GO:0003275 biolink:BiologicalProcess apoptotic process involved in outflow tract morphogenesis Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. go.json apoptosis involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_0003275 GO:0003270 biolink:BiologicalProcess Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json Notch signaling pathway involved in regulation of second heart field cardioblast proliferation|Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation http://purl.obolibrary.org/obo/GO_0003270 GO:0003272 biolink:BiologicalProcess endocardial cushion formation The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. go.json http://purl.obolibrary.org/obo/GO_0003272 GO:0003271 biolink:BiologicalProcess smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation|hh signaling pathway involved in regulation of second heart field cardioblast proliferation|smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation|smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation|smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation http://purl.obolibrary.org/obo/GO_0003271 GO:0198738 biolink:BiologicalProcess cell-cell signaling by wnt Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell. go.json http://purl.obolibrary.org/obo/GO_0198738 GO:0003289 biolink:BiologicalProcess atrial septum primum morphogenesis The process in which anatomical structure of an atrial septum primum is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003289 GO:0003288 biolink:BiologicalProcess ventricular septum intermedium morphogenesis The developmental process in which a ventricular septum intermedium is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003288 GO:0003285 biolink:BiologicalProcess septum secundum development The progression of the septum secundum over time, from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003285 GO:0003284 biolink:BiologicalProcess septum primum development The progression of the septum primum over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003284 GO:0003287 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003287 GO:0003286 biolink:BiologicalProcess atrial septum intermedium development The progression of the atrial septum intermedium over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003286 GO:0003281 biolink:BiologicalProcess ventricular septum development The progression of the ventricular septum over time from its formation to the mature structure. go.json interventricular septum development|septum inferius development http://purl.obolibrary.org/obo/GO_0003281 GO:0003280 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003280 GO:0003283 biolink:BiologicalProcess atrial septum development The progression of the atrial septum over time, from its initial formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003283 GO:0003282 biolink:BiologicalProcess ventricular septum intermedium development The progression of the ventricular septum intermedium over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003282 GO:0003290 biolink:BiologicalProcess atrial septum secundum morphogenesis The process in which anatomical structure of an atrial septum secundum is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003290 GO:0003259 biolink:BiologicalProcess cardioblast anterior-lateral migration The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0003259 GO:0003256 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell. go.json True http://purl.obolibrary.org/obo/GO_0003256 GO:0003255 biolink:BiologicalProcess endocardial precursor cell differentiation The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate. go.json http://purl.obolibrary.org/obo/GO_0003255 GO:0003258 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell. go.json True http://purl.obolibrary.org/obo/GO_0003258 GO:0003257 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell. go.json True http://purl.obolibrary.org/obo/GO_0003257 GO:0003252 biolink:BiologicalProcess negative regulation of cell proliferation involved in heart valve morphogenesis Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. go.json http://purl.obolibrary.org/obo/GO_0003252 GO:0003251 biolink:BiologicalProcess positive regulation of cell proliferation involved in heart valve morphogenesis Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. go.json http://purl.obolibrary.org/obo/GO_0003251 GO:0003254 biolink:BiologicalProcess regulation of membrane depolarization Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. go.json http://purl.obolibrary.org/obo/GO_0003254 GO:0003253 biolink:BiologicalProcess cardiac neural crest cell migration involved in outflow tract morphogenesis The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. go.json http://purl.obolibrary.org/obo/GO_0003253 GO:0003250 biolink:BiologicalProcess regulation of cell proliferation involved in heart valve morphogenesis Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. go.json http://purl.obolibrary.org/obo/GO_0003250 GO:0003267 biolink:BiologicalProcess canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation|canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation|canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation http://purl.obolibrary.org/obo/GO_0003267 GO:0003266 biolink:BiologicalProcess regulation of secondary heart field cardioblast proliferation Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). go.json regulation of SHF cardioblast proliferation|regulation of second heart field cardioblast proliferation http://purl.obolibrary.org/obo/GO_0003266 GO:0003269 biolink:BiologicalProcess obsolete BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json BMP signaling pathway involved in regulation of second heart field cardioblast proliferation|BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation True http://purl.obolibrary.org/obo/GO_0003269 GO:0003268 biolink:BiologicalProcess fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation|fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation|fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation http://purl.obolibrary.org/obo/GO_0003268 GO:0003263 biolink:BiologicalProcess cardioblast proliferation The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0003263 GO:0003262 biolink:BiologicalProcess endocardial progenitor cell migration to the midline involved in heart field formation The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart. go.json http://purl.obolibrary.org/obo/GO_0003262 GO:0003265 biolink:BiologicalProcess regulation of primary heart field cardioblast proliferation Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle. go.json regulation of FHF cardioblast proliferation|regulation of first heart field cardiac proliferation|regulation of first heart field cardioblast proliferation http://purl.obolibrary.org/obo/GO_0003265 GO:0003264 biolink:BiologicalProcess regulation of cardioblast proliferation Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0003264 GO:0003261 biolink:BiologicalProcess cardiac muscle progenitor cell migration to the midline involved in heart field formation The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart. go.json myocardial progenitor cell midline convergence http://purl.obolibrary.org/obo/GO_0003261 GO:0003260 biolink:BiologicalProcess cardioblast migration The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0003260 GO:0003238 biolink:BiologicalProcess conus arteriosus development The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. go.json http://purl.obolibrary.org/obo/GO_0003238 GO:0003237 biolink:BiologicalProcess sinus venosus formation The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. go.json http://purl.obolibrary.org/obo/GO_0003237 GO:0003239 biolink:BiologicalProcess conus arteriosus morphogenesis The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. go.json http://purl.obolibrary.org/obo/GO_0003239 GO:0003234 biolink:BiologicalProcess bulbus arteriosus formation The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart. go.json http://purl.obolibrary.org/obo/GO_0003234 GO:0003233 biolink:BiologicalProcess bulbus arteriosus morphogenesis The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber. go.json http://purl.obolibrary.org/obo/GO_0003233 GO:0003236 biolink:BiologicalProcess sinus venosus morphogenesis The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. go.json http://purl.obolibrary.org/obo/GO_0003236 GO:0003235 biolink:BiologicalProcess sinus venosus development The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. go.json http://purl.obolibrary.org/obo/GO_0003235 GO:0003230 biolink:BiologicalProcess cardiac atrium development The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. go.json http://purl.obolibrary.org/obo/GO_0003230 GO:0003232 biolink:BiologicalProcess bulbus arteriosus development The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber. go.json http://purl.obolibrary.org/obo/GO_0003232 GO:0003231 biolink:BiologicalProcess cardiac ventricle development The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. go.json http://purl.obolibrary.org/obo/GO_0003231 GO:0003249 biolink:BiologicalProcess cell proliferation involved in heart valve morphogenesis The multiplication or reproduction of cells that contributes to the shaping of a heart valve. go.json http://purl.obolibrary.org/obo/GO_0003249 GO:0003248 biolink:BiologicalProcess heart capillary growth The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. go.json http://purl.obolibrary.org/obo/GO_0003248 GO:0003245 biolink:BiologicalProcess cardiac muscle tissue growth involved in heart morphogenesis The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0003245 GO:0003244 biolink:BiologicalProcess radial growth involved in right ventricle morphogenesis The morphogenic growth in which the right ventricle grows along a radial axis. go.json http://purl.obolibrary.org/obo/GO_0003244 GO:0003247 biolink:BiologicalProcess post-embryonic cardiac muscle cell growth involved in heart morphogenesis The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0003247 GO:0003246 biolink:BiologicalProcess embryonic cardiac muscle cell growth involved in heart morphogenesis The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart. go.json embryonic cardiac muscle physiological hypertrophy http://purl.obolibrary.org/obo/GO_0003246 GO:0003241 biolink:BiologicalProcess growth involved in heart morphogenesis Developmental growth that contributes to the shaping of the heart. go.json http://purl.obolibrary.org/obo/GO_0003241 GO:0003240 biolink:BiologicalProcess conus arteriosus formation The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. go.json http://purl.obolibrary.org/obo/GO_0003240 GO:0003243 biolink:BiologicalProcess circumferential growth involved in left ventricle morphogenesis The morphogenetic growth in which the left ventricle grows expanding its external boundary. go.json http://purl.obolibrary.org/obo/GO_0003243 GO:0003242 biolink:BiologicalProcess cardiac chamber ballooning The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping. go.json http://purl.obolibrary.org/obo/GO_0003242 GO:0003216 biolink:BiologicalProcess cardiac left atrium formation The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0003216 GO:0003215 biolink:BiologicalProcess cardiac right ventricle morphogenesis The process in which the right cardiac ventricle is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003215 GO:0003218 biolink:BiologicalProcess cardiac left ventricle formation The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0003218 GO:0003217 biolink:BiologicalProcess cardiac right atrium formation The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0003217 GO:0003212 biolink:BiologicalProcess cardiac left atrium morphogenesis The process in which the left cardiac atrium is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003212 GO:0003211 biolink:BiologicalProcess cardiac ventricle formation The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. go.json http://purl.obolibrary.org/obo/GO_0003211 GO:0003214 biolink:BiologicalProcess cardiac left ventricle morphogenesis The process in which the left cardiac ventricle is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003214 GO:0003213 biolink:BiologicalProcess cardiac right atrium morphogenesis The process in which the right cardiac atrium is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003213 GO:0003210 biolink:BiologicalProcess cardiac atrium formation The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. go.json http://purl.obolibrary.org/obo/GO_0003210 GO:0003219 biolink:BiologicalProcess cardiac right ventricle formation The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0003219 GO:0003227 biolink:BiologicalProcess right ventricular trabecular myocardium morphogenesis The process in which the anatomical structures of the right ventricular myocardium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003227 GO:0003226 biolink:BiologicalProcess right ventricular compact myocardium morphogenesis The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003226 GO:0003229 biolink:BiologicalProcess ventricular cardiac muscle tissue development The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. go.json ventricular myocardium development http://purl.obolibrary.org/obo/GO_0003229 GO:0003228 biolink:BiologicalProcess atrial cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. go.json atrial myocardium development http://purl.obolibrary.org/obo/GO_0003228 GO:0003223 biolink:BiologicalProcess ventricular compact myocardium morphogenesis The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003223 GO:0003222 biolink:BiologicalProcess ventricular trabecula myocardium morphogenesis The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. go.json trabecula carnea morphogenesis http://purl.obolibrary.org/obo/GO_0003222 GO:0003225 biolink:BiologicalProcess left ventricular trabecular myocardium morphogenesis The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003225 GO:0003224 biolink:BiologicalProcess left ventricular compact myocardium morphogenesis The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003224 GO:0003221 biolink:BiologicalProcess right ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. go.json right ventricle myocardium morphogenesis http://purl.obolibrary.org/obo/GO_0003221 GO:0003220 biolink:BiologicalProcess left ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. go.json left ventricular myocardium morphogenesis http://purl.obolibrary.org/obo/GO_0003220 GO:0052326 biolink:BiologicalProcess obsolete interaction with symbiont via protein secreted by type IV secretion system OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json interaction with symbiont via protein secreted by type IV secretion system True http://purl.obolibrary.org/obo/GO_0052326 GO:0052325 biolink:BiologicalProcess cell wall pectin biosynthetic process The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. go.json cell wall pectin biosynthesis|pectin biosynthesis during cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0052325 GO:0052324 biolink:BiologicalProcess plant-type cell wall cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. go.json cell wall cellulose biosynthesis|cellulose biosynthesis during cell wall biosynthesis http://purl.obolibrary.org/obo/GO_0052324 GO:0052323 biolink:BiologicalProcess negative regulation of phytoalexin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. go.json down regulation of phytoalexin biosynthesis|down-regulation of phytoalexin biosynthesis|downregulation of phytoalexin biosynthesis|inhibition of phytoalexin biosynthesis|negative regulation of phytoalexin biosynthesis http://purl.obolibrary.org/obo/GO_0052323 GO:0052329 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052329 GO:0052328 biolink:BiologicalProcess obsolete interaction with symbiont via protein secreted by type III secretion system OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json interaction with symbiont via protein secreted by type III secretion system True http://purl.obolibrary.org/obo/GO_0052328 GO:0052327 biolink:BiologicalProcess obsolete interaction with symbiont via protein secreted by type II secretion system OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json interaction with symbiont via protein secreted by type II secretion system True http://purl.obolibrary.org/obo/GO_0052327 GO:0052322 biolink:BiologicalProcess positive regulation of phytoalexin biosynthetic process Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. go.json activation of phytoalexin biosynthesis|positive regulation of phytoalexin biosynthesis|stimulation of phytoalexin biosynthesis|up regulation of phytoalexin biosynthesis|up-regulation of phytoalexin biosynthesis|upregulation of phytoalexin biosynthesis http://purl.obolibrary.org/obo/GO_0052322 GO:0052321 biolink:BiologicalProcess negative regulation of phytoalexin metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins. go.json down regulation of phytoalexin metabolism|down-regulation of phytoalexin metabolism|downregulation of phytoalexin metabolism|inhibition of phytoalexin metabolism|negative regulation of phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0052321 GO:0052320 biolink:BiologicalProcess positive regulation of phytoalexin metabolic process Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins. go.json activation of phytoalexin metabolism|positive regulation of phytoalexin metabolism|stimulation of phytoalexin metabolism|up regulation of phytoalexin metabolism|up-regulation of phytoalexin metabolism|upregulation of phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0052320 GO:0160007 biolink:BiologicalProcess glutathione import into mitochondrion The process in which glutathione is transported from the cytosol into the mitochondrial matrix. go.json http://purl.obolibrary.org/obo/GO_0160007 GO:0052337 biolink:BiologicalProcess obsolete disruption by host of symbiont membrane OBSOLETE. The process in which a host organism destabilizes a symbiont membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modification by host of symbiont cell membrane|modification by host of symbiont membrane True http://purl.obolibrary.org/obo/GO_0052337 GO:0160006 biolink:BiologicalProcess Fc receptor-mediated immune complex endocytosis An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I. go.json Fc receptor-mediated immune complex internalization|Ig-complexed antigen endocytosis via Fc receptor|antigen-antibody immune complex uptake via Fc receptor http://purl.obolibrary.org/obo/GO_0160006 GO:0052336 biolink:BiologicalProcess obsolete modification by host of symbiont cell wall OBSOLETE. The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json metabolism of symbiont cell wall by organism True http://purl.obolibrary.org/obo/GO_0052336 GO:0160009 biolink:MolecularActivity histone decrotonylase activity Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]. go.json http://purl.obolibrary.org/obo/GO_0160009 GO:0052335 biolink:BiologicalProcess obsolete modification by host of symbiont cytoskeleton OBSOLETE. The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052335 GO:0052334 biolink:BiologicalProcess obsolete modification by organism of cytoskeleton of other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction. go.json modification by organism of cytoskeleton of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052334 GO:0160008 biolink:MolecularActivity protein decrotonylase activity Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]. RHEA:69172 go.json http://purl.obolibrary.org/obo/GO_0160008 GO:0160003 biolink:MolecularActivity mono-ADP-D-ribose modification-dependent protein binding Binding to a protein upon mono-ADP-ribosylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0160003 GO:0160002 biolink:MolecularActivity ADP-D-ribose modification-dependent protein binding Binding to a protein upon ADP-ribosylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0160002 GO:0052339 biolink:BiologicalProcess obsolete disruption by organism of cell wall of other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json disassembly by organism of cell wall of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052339 GO:0160005 biolink:CellularComponent PAT complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47. go.json http://purl.obolibrary.org/obo/GO_0160005 GO:0052338 biolink:BiologicalProcess obsolete perturbation by host of symbiont cell wall OBSOLETE. The perturbation by an organism of the symbiont cell wall, leading to damage or temporary subversion of the cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json catabolism of symbiont cell wall by organism|degradation of symbiont cell wall by organism|disassembly by host of symbiont cell wall|disruption by host of symbiont cell wall True http://purl.obolibrary.org/obo/GO_0052338 GO:0160004 biolink:MolecularActivity poly-ADP-D-ribose modification-dependent protein binding Binding to a protein upon poly-ADP-ribosylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0160004 GO:0160001 biolink:BiologicalProcess extrasynaptic signaling via GABA Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid. go.json http://purl.obolibrary.org/obo/GO_0160001 GO:0052333 biolink:BiologicalProcess obsolete modification by organism of cell wall of other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of cell wall of other organism|modification by organism of cell wall of other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052333 GO:0052332 biolink:BiologicalProcess obsolete modification by organism of membrane in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism effects a change in the structure or function of a cellular membrane of a second organism, where the two organisms are in a symbiotic interaction. go.json modification by organism of cell membrane in other organism during symbiotic interaction|modification by organism of cell membrane in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052332 GO:0052331 biolink:BiologicalProcess obsolete hemolysis in other organism involved in symbiotic interaction OBSOLETE. The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction. go.json haemolysis in other organism involved in symbiotic interaction|hemolysin activity|hemolysis by organism of RBCs in other organism during symbiotic interaction|hemolysis by organism of erythrocytes in other organism during symbiotic interaction|hemolysis by organism of red blood cells in other organism during symbiotic interaction|hemolysis of cells in other organism during symbiotic interaction|hemolysis of cells in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052331 GO:0052330 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052330 GO:0052348 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052348 GO:0052347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052347 GO:0052346 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont nitric oxide production OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of defense-related symbiont NO production|positive regulation by organism of defense-related symbiont nitric oxide production True http://purl.obolibrary.org/obo/GO_0052346 GO:0052345 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052345 GO:0052349 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont reactive oxygen species production OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of defense-related symbiont AOS production|positive regulation by organism of defense-related symbiont ROI production|positive regulation by organism of defense-related symbiont ROS production|positive regulation by organism of defense-related symbiont active oxygen species production|positive regulation by organism of defense-related symbiont metabolic burst|positive regulation by organism of defense-related symbiont oxidative burst|positive regulation by organism of defense-related symbiont reactive oxidative species production|positive regulation by organism of defense-related symbiont reactive oxygen intermediate production|positive regulation by organism of defense-related symbiont reactive oxygen species production|positive regulation by organism of defense-related symbiont respiratory burst True http://purl.obolibrary.org/obo/GO_0052349 GO:0052340 biolink:BiologicalProcess obsolete catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of cell wall cellulose in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052340 GO:0052344 biolink:BiologicalProcess positive regulation by symbiont of host phytoalexin production Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host phytoalexin production|positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction|stimulation by symbiont of host phytoalexin production|up regulation by symbiont of host phytoalexin production|up-regulation by symbiont of host phytoalexin production|upregulation by symbiont of host phytoalexin production http://purl.obolibrary.org/obo/GO_0052344 GO:0052343 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont phytoalexin production OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of symbiont phytoalexin production True http://purl.obolibrary.org/obo/GO_0052343 GO:0052342 biolink:BiologicalProcess obsolete catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of cell wall chitin in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052342 GO:0052341 biolink:BiologicalProcess obsolete catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of cell wall pectin in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052341 GO:0052359 biolink:BiologicalProcess obsolete catabolism by organism of glucan in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of glucan in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052359 GO:0052358 biolink:BiologicalProcess obsolete catabolism by host of symbiont glucan OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052358 GO:0052357 biolink:BiologicalProcess obsolete catabolism by host of symbiont cell wall pectin OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052357 GO:0052356 biolink:BiologicalProcess obsolete catabolism by host of symbiont cell wall chitin OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052356 GO:0052351 biolink:BiologicalProcess obsolete induction by organism of systemic acquired resistance in symbiont OBSOLETE. Any process in which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of SAR in symbiont|activation by organism of systemic acquired resistance in symbiont|induction by organism of SAR in symbiont|induction by organism of systemic acquired resistance in symbiont True http://purl.obolibrary.org/obo/GO_0052351 GO:0052350 biolink:BiologicalProcess obsolete induction by organism of induced systemic resistance in symbiont OBSOLETE. Any process in which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of ISR in symbiont|activation by organism of induced systemic resistance in symbiont|induction by organism of ISR in symbiont|induction by organism of induced systemic resistance in symbiont True http://purl.obolibrary.org/obo/GO_0052350 GO:0052355 biolink:BiologicalProcess obsolete catabolism by host of symbiont cell wall cellulose OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052355 GO:0052354 biolink:BiologicalProcess obsolete catabolism by organism of carbohydrate in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of carbohydrate in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052354 GO:0052353 biolink:BiologicalProcess obsolete catabolism by host of symbiont carbohydrate OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052353 GO:0052352 biolink:BiologicalProcess obsolete biosynthesis by host of substance in symbiont OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052352 GO:0052369 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052369 GO:0052368 biolink:BiologicalProcess obsolete disruption by organism of cellular component in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism of cellular component in other organism|catabolism of structural constituent in other organism|degradation of cellular component in other organism|disassembly by organism of cellular component in other organism during symbiotic interaction|disassembly by organism of cellular component in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052368 GO:0052367 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052367 GO:0052362 biolink:BiologicalProcess obsolete catabolism by host of symbiont protein OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052362 GO:0052361 biolink:BiologicalProcess obsolete catabolism by organism of macromolecule in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of macromolecule in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052361 GO:0052360 biolink:BiologicalProcess obsolete catabolism by host of symbiont macromolecule OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052360 GO:0052366 biolink:BiologicalProcess obsolete catabolism by organism of xylan in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of xylan in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052366 GO:0052365 biolink:BiologicalProcess obsolete catabolism by host of symbiont xylan OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052365 GO:0052364 biolink:BiologicalProcess obsolete catabolism by host of substance in symbiont OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052364 GO:0052363 biolink:BiologicalProcess obsolete catabolism by organism of protein in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction. go.json catabolism by organism of protein in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052363 GO:0052379 biolink:BiologicalProcess obsolete modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction OBSOLETE. Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction. go.json modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction|modulation by organism of entry into other organism via phagocytosis during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052379 GO:0052378 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052378 GO:0052373 biolink:BiologicalProcess suppression of symbiont entry into host Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction. go.json down regulation by organism of entry into other organism during symbiotic interaction|down-regulation by organism of entry into other organism during symbiotic interaction|downregulation by organism of entry into other organism during symbiotic interaction|inhibition by organism of entry into other organism during symbiotic interaction|negative regulation by organism of entry into other organism during symbiotic interaction|negative regulation by organism of entry into other organism involved in symbiotic interaction|suppression of symbiont entry into host by host http://purl.obolibrary.org/obo/GO_0052373 GO:0052372 biolink:BiologicalProcess modulation by symbiont of entry into host Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. go.json modulation by organism of entry into other organism during symbiotic interaction|regulation by organism of entry into other organism during symbiotic interaction|regulation by organism of entry into other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052372 GO:0052371 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052371 GO:0052370 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052370 GO:0052377 biolink:BiologicalProcess obsolete evasion or tolerance by organism of symbiont-produced phytoalexins OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json evasion or tolerance by organism of symbiont phytoalexins|evasion or tolerance by organism of symbiont-produced phytoalexins|evasion or tolerance of phytoalexins produced by symbiont in response to organism|symbiont phytoalexin detoxification True http://purl.obolibrary.org/obo/GO_0052377 GO:0052376 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052376 GO:0052375 biolink:BiologicalProcess obsolete evasion or tolerance by organism of symbiont-produced nitric oxide OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json evasion or tolerance by organism of symbiont NO|evasion or tolerance by organism of symbiont nitric oxide|evasion or tolerance by organism of symbiont-produced NO|evasion or tolerance by organism of symbiont-produced nitric oxide|evasion or tolerance of NO produced by symbiont in response to organism|evasion or tolerance of nitric oxide produced by symbiont in response to organism True http://purl.obolibrary.org/obo/GO_0052375 GO:0052374 biolink:BiologicalProcess obsolete negative regulation by symbiont of entry into host OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. go.json down regulation by symbiont of entry into host|down-regulation by symbiont of entry into host|downregulation by symbiont of entry into host|inhibition by symbiont of entry into host True http://purl.obolibrary.org/obo/GO_0052374 GO:0052389 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052389 GO:0052380 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052380 GO:0052384 biolink:BiologicalProcess obsolete evasion or tolerance by organism of symbiont-produced reactive oxygen species OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json evasion by organism of cellular damage caused by symbiont oxidative burst|evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response|evasion or tolerance by organism of symbiont-produced reactive oxygen species|evasion or tolerance of defense-related symbiont metabolic burst|evasion or tolerance of defense-related symbiont oxidative burst|evasion or tolerance of defense-related symbiont respiratory burst|evasion or tolerance of reactive oxygen species produced by symbiont in response to organism|evasion or tolerance of symbiont-produced AOS|evasion or tolerance of symbiont-produced ROIs|evasion or tolerance of symbiont-produced ROS|evasion or tolerance of symbiont-produced active oxygen species|evasion or tolerance of symbiont-produced reactive oxygen intermediates True http://purl.obolibrary.org/obo/GO_0052384 GO:0052383 biolink:BiologicalProcess obsolete induction by organism of symbiont innate immunity OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont innate immune response|activation by organism of symbiont innate immunity|induction by organism of symbiont innate immune response|induction by organism of symbiont innate immunity True http://purl.obolibrary.org/obo/GO_0052383 GO:0052382 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052382 GO:0052381 biolink:MolecularActivity tRNA dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine. EC:2.5.1.75|MetaCyc:RXN0-6274|RHEA:26482|Reactome:R-HSA-6784462|Reactome:R-HSA-6787567 go.json dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity|tRNA isopentenyltransferase activity|tRNA prenyltransferase activity http://purl.obolibrary.org/obo/GO_0052381 GO:0052388 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052388 GO:0052387 biolink:BiologicalProcess obsolete induction by organism of symbiont apoptosis OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont apoptosis|activation by organism of symbiont apoptotic programmed cell death|induction by organism of symbiont apoptosis|induction by organism of symbiont apoptotic programmed cell death True http://purl.obolibrary.org/obo/GO_0052387 GO:0052386 biolink:BiologicalProcess cell wall thickening A type of cell wall modification in which the cell wall is reinforced and made thicker. go.json http://purl.obolibrary.org/obo/GO_0052386 GO:0052385 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052385 GO:0052391 biolink:BiologicalProcess induction by symbiont of defense-related host calcium ion flux The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of host Ca2+ flux|activation by organism of host calcium ion flux|activation by symbiont of defense-related host calcium ion flux|induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|induction by organism of host Ca2+ flux|positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|positive regulation by organism of defense-related host Ca2+ flux|positive regulation by symbiont of defense-related host calcium ion flux|stimulation by symbiont of defense-related host calcium ion flux|up regulation by symbiont of defense-related host calcium ion flux|up-regulation by symbiont of defense-related host calcium ion flux|upregulation by symbiont of defense-related host calcium ion flux http://purl.obolibrary.org/obo/GO_0052391 GO:0052390 biolink:BiologicalProcess induction by symbiont of host innate immune response The activation by a symbiont of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by organism of host innate immune response|activation by organism of host innate immunity|activation by symbiont of host innate immunity|induction by organism of host innate immune response|induction by organism of innate immune response in other organism involved in symbiotic interaction|induction by symbiont of host innate immunity|induction of host innate immunity|positive regulation by symbiont of host innate immune response|positive regulation by symbiont of host innate immunity|positive regulation of host innate immune response|positive regulation of innate immune response in other organism|stimulation by symbiont of host innate immunity|up regulation by symbiont of host innate immunity|up-regulation by symbiont of host innate immunity|upregulation by symbiont of host innate immunity http://purl.obolibrary.org/obo/GO_0052390 GO:0052395 biolink:BiologicalProcess obsolete induction by organism of defense-related symbiont nitric oxide production OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related symbiont NO production|activation by organism of defense-related symbiont nitric acid production|induction by organism of defense-related symbiont NO production|induction by organism of defense-related symbiont nitric oxide production True http://purl.obolibrary.org/obo/GO_0052395 GO:0052394 biolink:BiologicalProcess obsolete induction by organism of defense-related symbiont cell wall thickening OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont defense-related cell wall thickening|activation by organism of symbiont defensive cell wall thickening|induction by organism of defense-related symbiont cell wall thickening|induction by organism of symbiont defensive cell wall thickening True http://purl.obolibrary.org/obo/GO_0052394 GO:0052393 biolink:BiologicalProcess obsolete induction by host of symbiont defense response OBSOLETE. The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation of symbiont defense response True http://purl.obolibrary.org/obo/GO_0052393 GO:0052392 biolink:BiologicalProcess obsolete induction by organism of defense-related symbiont calcium ion flux OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont Ca2+ flux|activation by organism of symbiont calcium ion flux|induction by organism of defense-related symbiont calcium ion flux|induction by organism of symbiont Ca2+ flux True http://purl.obolibrary.org/obo/GO_0052392 GO:0052399 biolink:BiologicalProcess obsolete induction by organism of symbiont programmed cell death OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont programmed cell death|induction by organism of symbiont programmed cell death True http://purl.obolibrary.org/obo/GO_0052399 GO:0052398 biolink:BiologicalProcess obsolete induction by organism of symbiont phytoalexin production OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont phytoalexin production|induction by organism of symbiont phytoalexin production True http://purl.obolibrary.org/obo/GO_0052398 GO:0052397 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052397 GO:0052396 biolink:BiologicalProcess obsolete induction by organism of symbiont non-apoptotic programmed cell death OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont non-apoptotic programmed cell death|induction by organism of symbiont non-apoptotic programmed cell death True http://purl.obolibrary.org/obo/GO_0052396 GO:0003315 biolink:BiologicalProcess heart rudiment formation The developmental process pertaining to the initial formation of the heart rudiment. go.json heart cone formation http://purl.obolibrary.org/obo/GO_0003315 GO:0003314 biolink:BiologicalProcess heart rudiment morphogenesis The process in which the anatomical structures of the heart rudiment are generated and organized. go.json heart cone morphogenesis http://purl.obolibrary.org/obo/GO_0003314 GO:0003317 biolink:BiologicalProcess cardioblast cell midline fusion The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment. go.json cardiac progenitor cell midline fusion http://purl.obolibrary.org/obo/GO_0003317 GO:0003316 biolink:BiologicalProcess establishment of myocardial progenitor cell apical/basal polarity The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment. go.json myocardial progenitor epithelial polarization http://purl.obolibrary.org/obo/GO_0003316 GO:0003311 biolink:BiologicalProcess pancreatic D cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. go.json pancreatic delta cell differentiation http://purl.obolibrary.org/obo/GO_0003311 GO:0160079 biolink:MolecularActivity G protein-coupled glycine receptor activity Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling. go.json mGlyR|metabotropic glycine receptor activity http://purl.obolibrary.org/obo/GO_0160079 GO:0003310 biolink:BiologicalProcess pancreatic A cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. go.json pancreatic alpha cell differentiation http://purl.obolibrary.org/obo/GO_0003310 GO:0003313 biolink:BiologicalProcess heart rudiment development The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. go.json heart cone development http://purl.obolibrary.org/obo/GO_0003313 GO:0003312 biolink:BiologicalProcess pancreatic PP cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. go.json pancreatic polypeptide-producing cell differentiation http://purl.obolibrary.org/obo/GO_0003312 GO:0042923 biolink:MolecularActivity neuropeptide binding Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). go.json http://purl.obolibrary.org/obo/GO_0042923 GO:0042922 biolink:MolecularActivity neuromedin U receptor binding Binding to one or more specific sites on a neuromedin U receptor. go.json http://purl.obolibrary.org/obo/GO_0042922 GO:0160070 biolink:BiologicalProcess intracellular borate homeostasis A homeostatic process involved in the maintenance of a steady state level of tetrahydroxoborate within a cell. go.json intracellular boron homeostasis|intracellular tetrahydroxoborate homeostasis http://purl.obolibrary.org/obo/GO_0160070 GO:0042925 biolink:MolecularActivity benzoate transmembrane transporter activity Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other. RHEA:32811 go.json benzoate transporter activity http://purl.obolibrary.org/obo/GO_0042925 GO:0042924 biolink:MolecularActivity neuromedin U binding Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. go.json NMU binding http://purl.obolibrary.org/obo/GO_0042924 GO:0042921 biolink:BiologicalProcess glucocorticoid receptor signaling pathway The series of molecular signals initiated by glucocorticoid binding to its receptor. go.json glucocorticoid receptor signalling pathway http://purl.obolibrary.org/obo/GO_0042921 GO:0042920 biolink:BiologicalProcess 3-hydroxyphenylpropionic acid transmembrane transport The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other. go.json 3-(3-hydroxyphenyl)propionic acid transport|3-hydroxyphenylpropionic acid transport|m-hydroxyphenylpropionic acid transport http://purl.obolibrary.org/obo/GO_0042920 GO:0160076 biolink:BiologicalProcess negative regulation of non-canonical inflammasome complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical inflammasome complex assembly. go.json http://purl.obolibrary.org/obo/GO_0160076 GO:0160075 biolink:BiologicalProcess non-canonical inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a non-canonical inflammasome complex. go.json http://purl.obolibrary.org/obo/GO_0160075 GO:0160078 biolink:BiologicalProcess negative regulation of lipid droplet fusion Any process that stops, prevents, or reduces the frequency, rate or extent of lipid droplet fusion. go.json http://purl.obolibrary.org/obo/GO_0160078 GO:0160077 biolink:BiologicalProcess lipid droplet fusion The process by which a single lipid droplet is created from the fusion of two or more lipid droplets. go.json http://purl.obolibrary.org/obo/GO_0160077 GO:0042927 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042927 GO:0003319 biolink:BiologicalProcess cardioblast migration to the midline involved in heart rudiment formation The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment. go.json http://purl.obolibrary.org/obo/GO_0003319 GO:0160072 biolink:MolecularActivity ubiquitin ligase complex scaffold activity The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way. go.json core protein activity for the CUL-RING ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0160072 GO:0042926 biolink:MolecularActivity 3-hydroxyphenylpropionic acid transmembrane transporter activity Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other. go.json 3-(3-hydroxyphenyl)propionic acid transporter activity|3-hydroxyphenylpropionic acid transporter activity|m-hydroxyphenylpropionic acid transporter activity http://purl.obolibrary.org/obo/GO_0042926 GO:0003318 biolink:BiologicalProcess cell migration to the midline involved in heart development The orderly movement of a cell toward the midline that contributes to the progression of the heart over time. go.json http://purl.obolibrary.org/obo/GO_0003318 GO:0160071 biolink:BiologicalProcess prevention of polyspermy during double fertilization The regulation of double fertilization forming a zygote and endosperm process that ensures that only a single sperm cell fertilizes one egg cell and another single sperm cell fertilizes one central cell. go.json http://purl.obolibrary.org/obo/GO_0160071 GO:0160074 biolink:CellularComponent non-canonical inflammasome complex An inflammasome complex containing CASP4, known as caspase-11 (Casp11) in mouse, which assembles upon cytosolic lipopolysaccharide-binding and directly activates Gasdermin-D (GSDMD). go.json http://purl.obolibrary.org/obo/GO_0160074 GO:0042929 biolink:MolecularActivity ferrichrome transmembrane transporter activity Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. go.json ferrichrome transporter activity http://purl.obolibrary.org/obo/GO_0042929 GO:0042928 biolink:BiologicalProcess ferrichrome import into cell A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. go.json ferrichrome transport http://purl.obolibrary.org/obo/GO_0042928 GO:0160073 biolink:BiologicalProcess Casparian strip assembly The aggregation, arrangement and bonding together of a set of components to form a Casparian strip, a region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material. go.json Casparian strip formation http://purl.obolibrary.org/obo/GO_0160073 GO:0003326 biolink:BiologicalProcess pancreatic A cell fate commitment The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. go.json http://purl.obolibrary.org/obo/GO_0003326 GO:0003325 biolink:BiologicalProcess pancreatic PP cell development The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. go.json http://purl.obolibrary.org/obo/GO_0003325 GO:0003328 biolink:BiologicalProcess pancreatic D cell fate commitment The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin. go.json http://purl.obolibrary.org/obo/GO_0003328 GO:0003327 biolink:BiologicalProcess type B pancreatic cell fate commitment The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. go.json pancreatic B cell fate commitment http://purl.obolibrary.org/obo/GO_0003327 GO:0003322 biolink:BiologicalProcess pancreatic A cell development The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. go.json pancreatic alpha cell development http://purl.obolibrary.org/obo/GO_0003322 GO:0003321 biolink:BiologicalProcess positive regulation of blood pressure by epinephrine-norepinephrine Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine. go.json http://purl.obolibrary.org/obo/GO_0003321 GO:0003324 biolink:BiologicalProcess pancreatic D cell development The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. go.json pancreatic delta cell development http://purl.obolibrary.org/obo/GO_0003324 GO:0003323 biolink:BiologicalProcess type B pancreatic cell development The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. go.json pancreatic B cell development|pancreatic beta cell development http://purl.obolibrary.org/obo/GO_0003323 GO:0003320 biolink:BiologicalProcess heart rudiment involution The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube. go.json http://purl.obolibrary.org/obo/GO_0003320 GO:0042934 biolink:MolecularActivity achromobactin transmembrane transporter activity Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other. go.json achromobactin transporter activity http://purl.obolibrary.org/obo/GO_0042934 GO:0042933 biolink:MolecularActivity chrysobactin transmembrane transporter activity Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other. go.json chrysobactin transporter activity http://purl.obolibrary.org/obo/GO_0042933 GO:0160081 biolink:MolecularActivity iodide channel activity Enables the facilitated diffusion of a iodide (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. RHEA:66324 go.json http://purl.obolibrary.org/obo/GO_0160081 GO:0042936 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042936 GO:0160080 biolink:MolecularActivity ABC-type indole transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out). go.json http://purl.obolibrary.org/obo/GO_0160080 GO:0042935 biolink:BiologicalProcess achromobactin transport The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042935 GO:0042930 biolink:BiologicalProcess enterobactin transport The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json enterochelin transport http://purl.obolibrary.org/obo/GO_0042930 GO:0042932 biolink:BiologicalProcess chrysobactin transport The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042932 GO:0042931 biolink:MolecularActivity enterobactin transmembrane transporter activity Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. go.json enterobactin transporter activity|enterochelin transporter activity http://purl.obolibrary.org/obo/GO_0042931 GO:0160087 biolink:BiologicalProcess spermatid cytoplasm removal during spermiation of flagellated sperm The process of removing the majority of the cytoplasm and organelles from a spermatid as it develops into a mature flagellated sperm cell. go.json http://purl.obolibrary.org/obo/GO_0160087 GO:0160086 biolink:BiologicalProcess protein localization to polar microtubule A process in which a protein is transported to, or maintained in, a location within a polar microtubule. go.json http://purl.obolibrary.org/obo/GO_0160086 GO:0160089 biolink:MolecularActivity internal N(7)-methylguanine-containing RNA reader activity A protein adaptor that recognizes and binds an RNA molecule modified by N(7)-methylguanine (m7G), a modification present at internal sites of mRNAs and some non-coding RNAs. go.json http://purl.obolibrary.org/obo/GO_0160089 GO:0042938 biolink:BiologicalProcess dipeptide transport The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042938 GO:0160083 biolink:BiologicalProcess exhausted T cell differentiation The process in which an activated T cell acquires specialized features of an exhausted T cell. go.json T cell dysfuction|T cell exhaustion http://purl.obolibrary.org/obo/GO_0160083 GO:0003329 biolink:BiologicalProcess pancreatic PP cell fate commitment The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. go.json http://purl.obolibrary.org/obo/GO_0003329 GO:0160082 biolink:MolecularActivity hypoxia-inducible factor-proline dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]. EC:1.14.11.29|RHEA:48400 go.json HIF hydroxylase|HIF prolyl hydroxylase http://purl.obolibrary.org/obo/GO_0160082 GO:0042937 biolink:MolecularActivity tripeptide transmembrane transporter activity Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. go.json tripeptide transporter activity http://purl.obolibrary.org/obo/GO_0042937 GO:0042939 biolink:BiologicalProcess tripeptide transport The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042939 GO:0160058 biolink:BiologicalProcess plant endodermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a plant endodermal cell. go.json http://purl.obolibrary.org/obo/GO_0160058 GO:0160057 biolink:BiologicalProcess plant endodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a plant endodermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. go.json http://purl.obolibrary.org/obo/GO_0160057 GO:0160059 biolink:BiologicalProcess programmed cell death in response to retinoic acid Cell death resulting from activation of endogenous cellular processes and occurring as a result of a retinoic acid. go.json retinoic acid-induced apoptosis http://purl.obolibrary.org/obo/GO_0160059 GO:0042945 biolink:MolecularActivity D-serine transmembrane transporter activity Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid. go.json D-serine permease activity|D-serine transporter activity http://purl.obolibrary.org/obo/GO_0042945 GO:0042944 biolink:MolecularActivity D-alanine transmembrane transporter activity Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid. go.json D-alanine transporter activity http://purl.obolibrary.org/obo/GO_0042944 GO:0042947 biolink:MolecularActivity glucoside transmembrane transporter activity Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue. go.json http://purl.obolibrary.org/obo/GO_0042947 GO:0042946 biolink:BiologicalProcess glucoside transport The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue. go.json http://purl.obolibrary.org/obo/GO_0042946 GO:0042941 biolink:BiologicalProcess D-alanine transport The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042941 GO:0042940 biolink:BiologicalProcess D-amino acid transport The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042940 GO:0042943 biolink:MolecularActivity D-amino acid transmembrane transporter activity Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids. go.json D-amino acid transporter activity http://purl.obolibrary.org/obo/GO_0042943 GO:0042942 biolink:BiologicalProcess D-serine transport The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042942 GO:0160054 biolink:BiologicalProcess microfibril assembly The aggregation, arrangement and bonding together of microfibril. go.json http://purl.obolibrary.org/obo/GO_0160054 GO:0160053 biolink:MolecularActivity serine-based site-specific recombinase activity Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphoseryl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a serine in the active site. go.json http://purl.obolibrary.org/obo/GO_0160053 GO:0160056 biolink:CellularComponent macropinosome membrane The lipid bilayer surrounding a macropinosome. go.json http://purl.obolibrary.org/obo/GO_0160056 GO:0160055 biolink:CellularComponent glideosome A protein complex composed of at least GAP45 (gliding-associated protein), GAP50 and myosin heavy and light chains. Anchored via GAP50 to the inner membrane complex of motile and invasive forms of apicomplexan parasites and regulates parasite gliding motility and invasion of host cells. go.json http://purl.obolibrary.org/obo/GO_0160055 GO:0160050 biolink:MolecularActivity xanthine binding Binding to xanthine, a purine base. go.json http://purl.obolibrary.org/obo/GO_0160050 GO:0042949 biolink:BiologicalProcess arbutin transport The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042949 GO:0042948 biolink:BiologicalProcess salicin transport The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042948 GO:0160052 biolink:BiologicalProcess mitotic nuclear envelope segregation The mitotic cell cycle process in which the nuclear envelope, including nuclear pores, is equally distributed to the two daughter cells during the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0160052 GO:0160051 biolink:CellularComponent Cyc8(Ssn6)-Tup1 general repressor complex A corepressor complex containing the WD-repeat protein Tup1p (S. cerevisiae) and Tup11/Tup12 (fission yeast) and the TPR repeat protein Cyc8p (S. cerevisiae) ssn6 (fission yeast) that is recruited to target genes by DNA-bound repressor proteins preferentially at regions where histones are deacetylated by the Clr6 class I HDAC, and recruits the SWI/SNF and SAGA complexes to promoters. go.json Tup11/Tup12 repressor complex http://purl.obolibrary.org/obo/GO_0160051 GO:0003304 biolink:BiologicalProcess myocardial epithelial involution involved in heart jogging The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging. go.json http://purl.obolibrary.org/obo/GO_0003304 GO:0003303 biolink:BiologicalProcess obsolete BMP signaling pathway involved in heart jogging OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging. go.json BMP signalling pathway involved in heart jogging True http://purl.obolibrary.org/obo/GO_0003303 GO:0003306 biolink:BiologicalProcess Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. go.json Wnt receptor signaling pathway involved in heart development|Wnt receptor signalling pathway involved in heart development|Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0003306 GO:0003305 biolink:BiologicalProcess cell migration involved in heart jogging The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging. go.json http://purl.obolibrary.org/obo/GO_0003305 GO:0003300 biolink:BiologicalProcess cardiac muscle hypertrophy The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. go.json http://purl.obolibrary.org/obo/GO_0003300 GO:0160069 biolink:BiologicalProcess surfactant secretion The regulated release of surfactant by a cell or tissue. go.json http://purl.obolibrary.org/obo/GO_0160069 GO:0160068 biolink:BiologicalProcess negative regulation of pollen tube guidance Any process that decreases the rate, frequency or extent of pollen tube guidance towards ovules. This is one mechanism to prevent polytuby, the simultaneous penetration of ovules by multiple pollen tubes. go.json prevention of polytuby http://purl.obolibrary.org/obo/GO_0160068 GO:0003302 biolink:BiologicalProcess obsolete transforming growth factor beta receptor signaling pathway involved in heart jogging OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging. go.json transforming growth factor beta receptor signalling pathway involved in heart jogging True http://purl.obolibrary.org/obo/GO_0003302 GO:0003301 biolink:BiologicalProcess physiological cardiac muscle hypertrophy The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. go.json http://purl.obolibrary.org/obo/GO_0003301 GO:0042950 biolink:MolecularActivity salicin transmembrane transporter activity Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042950 GO:0042956 biolink:BiologicalProcess maltodextrin transmembrane transport The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. go.json maltodextrin transport http://purl.obolibrary.org/obo/GO_0042956 GO:0042955 biolink:BiologicalProcess dextrin transport The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042955 GO:0042958 biolink:MolecularActivity maltodextrin transmembrane transporter activity Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042958 GO:0042957 biolink:MolecularActivity dextrin transmembrane transporter activity Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042957 GO:0042952 biolink:BiologicalProcess beta-ketoadipate pathway A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. go.json ortho-cleavage pathway http://purl.obolibrary.org/obo/GO_0042952 GO:0042951 biolink:MolecularActivity arbutin transmembrane transporter activity Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042951 GO:0042954 biolink:MolecularActivity obsolete lipoprotein transporter activity OBSOLETE. Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells. go.json True http://purl.obolibrary.org/obo/GO_0042954 GO:0042953 biolink:BiologicalProcess lipoprotein transport The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042953 GO:0160065 biolink:CellularComponent SIN/MEN signaling complex A protein complex associated with the mitotic spindle pole body during interphase and mitosis and comprises of the proteins of the septation initiation signaling network (SIN) of fission yeast or mitotic exit network (MEN) of budding yeast, organized by two scaffold/adaptor proteins. go.json Hippo signaling complex|MEN signaling complex|SIN signaling complex|SIN/MEN signalling complex http://purl.obolibrary.org/obo/GO_0160065 GO:0160064 biolink:CellularComponent multi-pass translocon complex A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47). go.json MPT complex|TMCO1 translocon http://purl.obolibrary.org/obo/GO_0160064 GO:0160067 biolink:CellularComponent new spindle pole body SIN signaling complex A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling. go.json new spindle pole body SIN signalling complex http://purl.obolibrary.org/obo/GO_0160067 GO:0160066 biolink:CellularComponent interphase SIN signaling complex A SIN signaling complex associated with the old mitotic spindle pole body during interphase and early M-phase and characterised by the presence active ubiquitin ligase (Dma1 in fission yeast) and GTPase activator (Spg1 in fission yeast) to inactivate SIN signaling. go.json interphase SIN signalling complex http://purl.obolibrary.org/obo/GO_0160066 GO:0160061 biolink:BiologicalProcess respiratory chemosensitivity A homeostatic process by which the sensing of CO2 and/or H+ by the brain leads to appropriate altering in breathing to regulate blood gas and tissue pH. go.json http://purl.obolibrary.org/obo/GO_0160061 GO:0003308 biolink:BiologicalProcess negative regulation of Wnt signaling pathway involved in heart development Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. go.json negative regulation of Wnt receptor signaling pathway involved in heart development|negative regulation of Wnt receptor signalling pathway involved in heart development|negative regulation of Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0003308 GO:0042959 biolink:MolecularActivity alkanesulfonate transmembrane transporter activity Enables the directed movement of alkanesulfonate from one side of a membrane to the other. go.json alkanesulfonate transporter activity|alkanesulphonate transporter activity http://purl.obolibrary.org/obo/GO_0042959 GO:0003307 biolink:BiologicalProcess regulation of Wnt signaling pathway involved in heart development Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. go.json regulation of Wnt receptor signaling pathway involved in heart development|regulation of Wnt receptor signalling pathway involved in heart development|regulation of Wnt-activated signaling pathway involved in heart development http://purl.obolibrary.org/obo/GO_0003307 GO:0160060 biolink:BiologicalProcess sleep homeostasis A homeostatic process in which the drive for sleep increases sleep propensity with prolonged wakefulness. go.json http://purl.obolibrary.org/obo/GO_0160060 GO:0160063 biolink:BiologicalProcess multi-pass transmembrane protein insertion into ER membrane A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions. go.json http://purl.obolibrary.org/obo/GO_0160063 GO:0003309 biolink:BiologicalProcess type B pancreatic cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. go.json pancreatic B cell differentiation|pancreatic beta cell differentiation http://purl.obolibrary.org/obo/GO_0003309 GO:0160062 biolink:BiologicalProcess cutin-based cuticle development The process whose specific outcome is the progression of the cutin-based cuticle over time, from its formation to the mature structure. Cutin-based cuticle is an extracellular structure composed of a covalently linked macromolecular scaffold of cutin and a variety of organic solvent-soluble lipids that are collectively termed waxes. Such structures are found on the external face of polysaccharide cell walls in land plants. go.json http://purl.obolibrary.org/obo/GO_0160062 GO:0160039 biolink:MolecularActivity serotonin-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. TC:1.A.9|Wikipedia:Ligand-gated_ion_channel go.json http://purl.obolibrary.org/obo/GO_0160039 GO:0160036 biolink:BiologicalProcess positive regulation of postsynaptic density assembly Any process that activates or increases the frequency, rate or extent of postsynaptic density assembly. go.json http://purl.obolibrary.org/obo/GO_0160036 GO:0160035 biolink:BiologicalProcess negative regulation of Toll receptor ligand protein activation cascade Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade. go.json http://purl.obolibrary.org/obo/GO_0160035 GO:0160038 biolink:BiologicalProcess somatic sensory system development The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. go.json somatosensory system development http://purl.obolibrary.org/obo/GO_0160038 GO:0160037 biolink:BiologicalProcess negative regulation of postsynaptic density assembly Any process that decreases the rate, frequency, or extent of postsynaptic density assembly. go.json http://purl.obolibrary.org/obo/GO_0160037 GO:0042961 biolink:MolecularActivity ATPase-coupled antimonite transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out). go.json ATP-dependent antimonite transporter activity|antimonite-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0042961 GO:0042960 biolink:MolecularActivity antimonite secondary active transmembrane transporter activity Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json antimonite porter activity http://purl.obolibrary.org/obo/GO_0042960 GO:0042967 biolink:BiologicalProcess obsolete acyl-carrier-protein biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of acyl-carrier protein. go.json ACP biosynthesis|ACP biosynthetic process|acyl carrier protein biosynthesis|acyl carrier protein biosynthetic process|acyl-carrier protein biosynthesis|acyl-carrier-protein anabolism|acyl-carrier-protein biosynthesis|acyl-carrier-protein formation|acyl-carrier-protein synthesis True http://purl.obolibrary.org/obo/GO_0042967 GO:0042966 biolink:BiologicalProcess biotin carboxyl carrier protein biosynthetic process The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase. go.json BCCP biosynthesis|BCCP biosynthetic process|biotin carboxyl carrier protein anabolism|biotin carboxyl carrier protein biosynthesis|biotin carboxyl carrier protein formation|biotin carboxyl carrier protein synthesis http://purl.obolibrary.org/obo/GO_0042966 GO:0042969 biolink:BiologicalProcess obsolete lactone transport OBSOLETE. The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. go.json True http://purl.obolibrary.org/obo/GO_0042969 GO:0042968 biolink:BiologicalProcess homoserine transport The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042968 GO:0042963 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042963 GO:0042962 biolink:MolecularActivity acridine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out). go.json acridine efflux pump activity|acridine:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0042962 GO:0042965 biolink:BiologicalProcess obsolete glutaredoxin biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase. go.json glutaredoxin anabolism|glutaredoxin biosynthesis|glutaredoxin formation|glutaredoxin synthesis True http://purl.obolibrary.org/obo/GO_0042965 GO:0042964 biolink:BiologicalProcess obsolete thioredoxin reduction OBSOLETE. The chemical reactions and pathways resulting in the reduction of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. go.json thioredoxin anabolism|thioredoxin biosynthesis|thioredoxin formation|thioredoxin synthesis True http://purl.obolibrary.org/obo/GO_0042964 GO:0160032 biolink:BiologicalProcess Toll receptor ligand protein activation cascade A protein activation cascade that generates the active Toll receptor ligand and consists of the cascade of enzymatic reactions initiated by extracellular recognition factors, leading to the cleavage of the inactive form of spatzle family of ligands. go.json http://purl.obolibrary.org/obo/GO_0160032 GO:0160031 biolink:BiologicalProcess endoplasmic reticulum membrane biogenesis The process in which an endoplasmic reticulum membrane is synthesized, aggregates, and bonds together. go.json ER membrane biogenesis http://purl.obolibrary.org/obo/GO_0160031 GO:0160034 biolink:BiologicalProcess positive regulation of Toll receptor ligand protein activation cascade Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade. go.json http://purl.obolibrary.org/obo/GO_0160034 GO:0160033 biolink:BiologicalProcess regulation of Toll receptor ligand protein activation cascade Any process that modulates the frequency, rate or extent of the Toll receptor ligand protein activation cascade. go.json http://purl.obolibrary.org/obo/GO_0160033 GO:0160030 biolink:BiologicalProcess pollen intine formation Formation of pollen intine, the inner layer of the pollen wall. The reticulate pollen wall pattern consists of two layers, exine and intine. go.json http://purl.obolibrary.org/obo/GO_0160030 GO:0160047 biolink:MolecularActivity muramyl dipeptide kinase activity Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H(+) + 6-O-phospho-muramyl dipeptide. go.json http://purl.obolibrary.org/obo/GO_0160047 GO:0160046 biolink:MolecularActivity oxalate:chloride antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out). go.json http://purl.obolibrary.org/obo/GO_0160046 GO:0160049 biolink:BiologicalProcess negative regulation of cGAS/STING signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0160049 GO:0160048 biolink:BiologicalProcess craniofacial suture closure The process of fusing together the edges of a craniofacial suture. go.json http://purl.obolibrary.org/obo/GO_0160048 GO:0042970 biolink:MolecularActivity homoserine transmembrane transporter activity Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. go.json homoserine transporter activity http://purl.obolibrary.org/obo/GO_0042970 GO:0042972 biolink:MolecularActivity licheninase activity Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds. EC:3.2.1.73|MetaCyc:3.2.1.73-RXN go.json 1,3-1,4-beta-D-glucan 4-glucanohydrolase activity|1,3-1,4-beta-glucan 4-glucanohydrolase activity|1,3;1,4-beta-glucan 4-glucanohydrolase activity|1,3;1,4-beta-glucan endohydrolase activity|beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity|beta-glucanase activity|endo-beta-1,3-1,4 glucanase activity|lichenase activity|mixed linkage beta-glucanase activity http://purl.obolibrary.org/obo/GO_0042972 GO:0042971 biolink:MolecularActivity obsolete lactone transmembrane transporter activity OBSOLETE. Enables the transfer of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. go.json True http://purl.obolibrary.org/obo/GO_0042971 GO:0042978 biolink:MolecularActivity ornithine decarboxylase activator activity Binds to and increases ornithine decarboxylase activity. go.json L-ornithine carboxy-lyase activator activity http://purl.obolibrary.org/obo/GO_0042978 GO:0042977 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042977 GO:0042979 biolink:MolecularActivity ornithine decarboxylase regulator activity Binds to and modulates the activity of the enzyme ornithine decarboxylase. go.json http://purl.obolibrary.org/obo/GO_0042979 GO:0042974 biolink:MolecularActivity nuclear retinoic acid receptor binding Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. go.json RAR binding|retinoic acid receptor binding http://purl.obolibrary.org/obo/GO_0042974 GO:0042973 biolink:MolecularActivity glucan endo-1,3-beta-D-glucosidase activity Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans. EC:3.2.1.39|MetaCyc:3.2.1.39-RXN go.json (1->3)-beta-glucan 3-glucanohydrolase activity|(1->3)-beta-glucan endohydrolase activity|1,3-beta-D-glucan 3-glucanohydrolase activity|1,3-beta-D-glucan glucanohydrolase activity|beta-1,3-glucanase|callase activity|endo-(1,3)-beta-D-glucanase activity|endo-(1->3)-beta-D-glucanase activity|endo-1,3-beta-D-glucanase|endo-1,3-beta-glucanase activity|endo-1,3-beta-glucosidase activity|kitalase activity|laminaranase activity|laminarinase activity|oligo-1,3-glucosidase activity http://purl.obolibrary.org/obo/GO_0042973 GO:0042976 biolink:BiologicalProcess activation of Janus kinase activity The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. go.json activation of JAK protein|activation of JAK protein by tyrosine phosphorylation|activation of JAK1 kinase activity|activation of JAK1 protein|activation of JAK2 kinase activity|activation of JAK2 protein|positive regulation of JAK protein activity by tyrosine phosphorylation|tyrosine phosphorylation of JAK protein|tyrosine phosphorylation of JAK1 protein|tyrosine phosphorylation of JAK2 protein http://purl.obolibrary.org/obo/GO_0042976 gocheck_do_not_annotate GO:0042975 biolink:MolecularActivity peroxisome proliferator activated receptor binding Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma. go.json PPAR binding http://purl.obolibrary.org/obo/GO_0042975 GO:0160043 biolink:BiologicalProcess catecholamine secretion, neurotransmission The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter. go.json http://purl.obolibrary.org/obo/GO_0160043 GO:0160042 biolink:MolecularActivity purine nucleotide uniporter activity Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. go.json http://purl.obolibrary.org/obo/GO_0160042 GO:0160045 biolink:CellularComponent TMEM240-body A multilamellar subcellular structure formed in the cytoplasm of developing neuron, composed of Tmem240 and Emd proteins. go.json T240-body http://purl.obolibrary.org/obo/GO_0160045 GO:0160044 biolink:MolecularActivity sulfate:chloride antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in). go.json http://purl.obolibrary.org/obo/GO_0160044 GO:0160041 biolink:MolecularActivity neuropeptide activity The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron. go.json http://purl.obolibrary.org/obo/GO_0160041 GO:0160040 biolink:BiologicalProcess mitocytosis A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells. go.json http://purl.obolibrary.org/obo/GO_0160040 GO:0160018 biolink:BiologicalProcess positive regulation of platelet rolling Any process that increases the rate, frequency, or extent of platelet rolling. go.json http://purl.obolibrary.org/obo/GO_0160018 GO:0052304 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052304 GO:0160017 biolink:BiologicalProcess regulation of platelet rolling Any process that modulates the frequency, rate or extent of platelet rolling. go.json http://purl.obolibrary.org/obo/GO_0160017 GO:0052303 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052303 GO:0052302 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052302 GO:0160019 biolink:BiologicalProcess negative regulation of platelet rolling Any process that decreases the rate, frequency, or extent of platelet rolling. go.json http://purl.obolibrary.org/obo/GO_0160019 GO:0052301 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052301 GO:0052308 biolink:BiologicalProcess obsolete pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction. go.json pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction|pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052308 GO:0160014 biolink:CellularComponent exopher An extracellular vesicle that is approximately four microns in diameter, released by budding out of cells into the extracellular space, and hypothesized to be a mechanism for disposal of unwanted cellular material including protein aggregates and damaged organelles. go.json http://purl.obolibrary.org/obo/GO_0160014 GO:0052307 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052307 GO:0160013 biolink:MolecularActivity NAD-dependent protein de-2-hydroxyisobutyrylase activity Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:24364 go.json http://purl.obolibrary.org/obo/GO_0160013 GO:0052306 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052306 GO:0160016 biolink:MolecularActivity CCACCA tRNA nucleotidyltransferase activity Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate. go.json http://purl.obolibrary.org/obo/GO_0160016 GO:0052305 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052305 GO:0160015 biolink:BiologicalProcess platelet rolling Transient adhesive interactions between platelets and endothelial cells lining blood vessels. Carbohydrates on circulating platelets bind selectins or other molecules on the vessel wall causing the platelets to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between surface molecules of platelets and endothelium. go.json http://purl.obolibrary.org/obo/GO_0160015 GO:0042981 biolink:BiologicalProcess regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process. go.json apoptosis regulator activity|regulation of apoptosis http://purl.obolibrary.org/obo/GO_0042981 GO:0042980 biolink:MolecularActivity obsolete cystic fibrosis transmembrane conductance regulator binding OBSOLETE. Binding to a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein. go.json CFTR binding|cystic fibrosis transmembrane conductance regulator binding True http://purl.obolibrary.org/obo/GO_0042980 GO:0042983 biolink:BiologicalProcess amyloid precursor protein biosynthetic process The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. go.json APP biosynthesis|APP biosynthetic process|amyloid precursor protein anabolism|amyloid precursor protein biosynthesis|amyloid precursor protein formation|amyloid precursor protein synthesis http://purl.obolibrary.org/obo/GO_0042983 GO:0042982 biolink:BiologicalProcess amyloid precursor protein metabolic process The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. go.json APP metabolic process|APP metabolism|amyloid precursor protein metabolism http://purl.obolibrary.org/obo/GO_0042982 GO:0052309 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052309 GO:0042989 biolink:BiologicalProcess sequestering of actin monomers The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. go.json actin monomer retention|actin monomer sequestering|actin monomer sequestering activity|actin monomer sequestration|actin monomer storage|retention of actin monomers|sequestration of actin monomers|storage of actin monomers http://purl.obolibrary.org/obo/GO_0042989 GO:0042988 biolink:MolecularActivity X11-like protein binding Binding to X11-like protein, a neuron-specific adaptor protein. go.json X11L binding http://purl.obolibrary.org/obo/GO_0042988 GO:0042985 biolink:BiologicalProcess negative regulation of amyloid precursor protein biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. go.json down regulation of amyloid precursor protein biosynthetic process|down-regulation of amyloid precursor protein biosynthetic process|downregulation of amyloid precursor protein biosynthetic process|inhibition of amyloid precursor protein biosynthetic process|negative regulation of APP biosynthesis|negative regulation of APP biosynthetic process|negative regulation of amyloid precursor protein anabolism|negative regulation of amyloid precursor protein biosynthesis|negative regulation of amyloid precursor protein formation|negative regulation of amyloid precursor protein synthesis http://purl.obolibrary.org/obo/GO_0042985 GO:0042984 biolink:BiologicalProcess regulation of amyloid precursor protein biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. go.json regulation of APP biosynthesis|regulation of APP biosynthetic process|regulation of amyloid precursor protein anabolism|regulation of amyloid precursor protein biosynthesis|regulation of amyloid precursor protein formation|regulation of amyloid precursor protein synthesis http://purl.obolibrary.org/obo/GO_0042984 GO:0042987 biolink:BiologicalProcess amyloid precursor protein catabolic process The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. go.json APP catabolic process|APP catabolism|amyloid precursor protein breakdown|amyloid precursor protein catabolism|amyloid precursor protein degradation http://purl.obolibrary.org/obo/GO_0042987 GO:0042986 biolink:BiologicalProcess positive regulation of amyloid precursor protein biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. go.json activation of amyloid precursor protein biosynthetic process|positive regulation of APP biosynthesis|positive regulation of APP biosynthetic process|positive regulation of amyloid precursor protein anabolism|positive regulation of amyloid precursor protein biosynthesis|positive regulation of amyloid precursor protein formation|positive regulation of amyloid precursor protein synthesis|stimulation of amyloid precursor protein biosynthetic process|up regulation of amyloid precursor protein biosynthetic process|up-regulation of amyloid precursor protein biosynthetic process|upregulation of amyloid precursor protein biosynthetic process http://purl.obolibrary.org/obo/GO_0042986 GO:0160010 biolink:MolecularActivity protein de-2-hydroxyisobutyrylase activity Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]. RHEA:69176 go.json http://purl.obolibrary.org/obo/GO_0160010 GO:0160012 biolink:MolecularActivity NAD-dependent histone decrotonylase activity Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide. go.json http://purl.obolibrary.org/obo/GO_0160012 GO:0160011 biolink:MolecularActivity NAD-dependent protein decrotonylase activity Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:69332 go.json http://purl.obolibrary.org/obo/GO_0160011 GO:0052300 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052300 GO:0052315 biolink:BiologicalProcess phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response. go.json phytoalexin biosynthesis http://purl.obolibrary.org/obo/GO_0052315 GO:0160029 biolink:BiologicalProcess kidney cortex tubule cell dedifferentiation The process in which a kidney cortex tubule cell (specialized epithelial cell of the kidney) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. go.json http://purl.obolibrary.org/obo/GO_0160029 GO:0052314 biolink:BiologicalProcess phytoalexin metabolic process The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. go.json phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0052314 goslim_pir GO:0160028 biolink:BiologicalProcess negative regulation of pyroptosis Any process that decreases the frequency, rate or extent of pyroptosis. go.json http://purl.obolibrary.org/obo/GO_0160028 GO:0052313 biolink:BiologicalProcess obsolete modulation of nutrient release from other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of nutrient release from other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052313 GO:0052312 biolink:BiologicalProcess obsolete modulation of transcription in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. go.json modulation of transcription in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052312 GO:0160025 biolink:BiologicalProcess sensory perception of itch A sensory perception which causes the desire or reflex to scratch. go.json pruritus http://purl.obolibrary.org/obo/GO_0160025 GO:0052319 biolink:BiologicalProcess regulation of phytoalexin biosynthetic process Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. go.json regulation of phytoalexin biosynthesis http://purl.obolibrary.org/obo/GO_0052319 GO:0160024 biolink:BiologicalProcess Leydig cell proliferation The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone. go.json http://purl.obolibrary.org/obo/GO_0160024 GO:0052318 biolink:BiologicalProcess regulation of phytoalexin metabolic process Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. go.json regulation of phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0052318 GO:0052317 biolink:BiologicalProcess camalexin metabolic process The chemical reactions and pathways involving camalexin, an indole phytoalexin. go.json camalexin metabolism http://purl.obolibrary.org/obo/GO_0052317 GO:0160027 biolink:BiologicalProcess egg deposition The multicellular organismal reproductive process that results in the movement of an egg from within an organism into the external environment. go.json http://purl.obolibrary.org/obo/GO_0160027 GO:0052316 biolink:BiologicalProcess phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response. go.json phytoalexin catabolism http://purl.obolibrary.org/obo/GO_0052316 GO:0042992 biolink:BiologicalProcess obsolete negative regulation of transcription factor import into nucleus OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. go.json down regulation of transcription factor import into nucleus|down-regulation of transcription factor import into nucleus|downregulation of transcription factor import into nucleus|inhibition of transcription factor import into nucleus|negative regulation of transcription factor import into cell nucleus|negative regulation of transcription factor transport from cytoplasm to nucleus|negative regulation of transcription factor-nucleus import True http://purl.obolibrary.org/obo/GO_0042992 GO:0042991 biolink:BiologicalProcess obsolete transcription factor import into nucleus OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus. go.json transcription factor import into cell nucleus|transcription factor transport from cytoplasm to nucleus|transcription factor-nucleus import True http://purl.obolibrary.org/obo/GO_0042991 GO:0042994 biolink:BiologicalProcess cytoplasmic sequestering of transcription factor The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. go.json cytoplasmic retention of transcription factor|cytoplasmic sequestration of transcription factor|cytoplasmic storage of transcription factor|maintenance of transcription factor protein location in cytoplasm|retention of transcription factor in cytoplasm|sequestering of transcription factor in cytoplasm|sequestration of transcription factor in cytoplasm|storage of transcription factor in cytoplasm|transcription factor binding, cytoplasmic sequestering http://purl.obolibrary.org/obo/GO_0042994 gocheck_do_not_annotate GO:0042993 biolink:BiologicalProcess obsolete positive regulation of transcription factor import into nucleus OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. go.json activation of transcription factor import into nucleus|positive regulation of transcription factor import into cell nucleus|positive regulation of transcription factor transport from cytoplasm to nucleus|positive regulation of transcription factor-nucleus import|stimulation of transcription factor import into nucleus|up regulation of transcription factor import into nucleus|up-regulation of transcription factor import into nucleus|upregulation of transcription factor import into nucleus True http://purl.obolibrary.org/obo/GO_0042993 GO:0042990 biolink:BiologicalProcess obsolete regulation of transcription factor import into nucleus OBSOLETE. Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. go.json regulation of transcription factor import into cell nucleus|regulation of transcription factor transport from cytoplasm to nucleus|regulation of transcription factor-nucleus import True http://purl.obolibrary.org/obo/GO_0042990 GO:0042999 biolink:BiologicalProcess obsolete regulation of Golgi to plasma membrane CFTR protein transport OBSOLETE. Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. go.json True http://purl.obolibrary.org/obo/GO_0042999 GO:0042996 biolink:BiologicalProcess regulation of Golgi to plasma membrane protein transport Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0042996 GO:0042995 biolink:CellularComponent cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon. go.json cell process|cellular process|cellular projection http://purl.obolibrary.org/obo/GO_0042995 goslim_agr|goslim_flybase_ribbon|goslim_mouse|goslim_pir|prokaryote_subset GO:0042998 biolink:BiologicalProcess positive regulation of Golgi to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. go.json activation of Golgi to plasma membrane protein transport|stimulation of Golgi to plasma membrane protein transport|up regulation of Golgi to plasma membrane protein transport|up-regulation of Golgi to plasma membrane protein transport|upregulation of Golgi to plasma membrane protein transport http://purl.obolibrary.org/obo/GO_0042998 GO:0042997 biolink:BiologicalProcess negative regulation of Golgi to plasma membrane protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. go.json down regulation of Golgi to plasma membrane protein transport|down-regulation of Golgi to plasma membrane protein transport|downregulation of Golgi to plasma membrane protein transport|inhibition of Golgi to plasma membrane protein transport http://purl.obolibrary.org/obo/GO_0042997 GO:0160021 biolink:BiologicalProcess maternal-to-zygotic transition of gene expression Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome. go.json MZT http://purl.obolibrary.org/obo/GO_0160021 GO:0160020 biolink:BiologicalProcess positive regulation of ferroptosis Any process that activates or increases the frequency, rate or extent of ferroptosis. go.json http://purl.obolibrary.org/obo/GO_0160020 GO:0160023 biolink:BiologicalProcess sneeze reflex A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane. go.json sternutation http://purl.obolibrary.org/obo/GO_0160023 GO:0160022 biolink:BiologicalProcess apocrine secretion The controlled release of a substance by a cell or a tissue by discharging a portion of the secreting cell when intracellular components are freed into a lumen through the shedding of whole pieces of the cytoplasm. go.json secretion by cell decapitation|secretion by membrane budding http://purl.obolibrary.org/obo/GO_0160022 GO:0052311 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052311 GO:0052310 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052310 GO:0003399 biolink:BiologicalProcess cytoneme morphogenesis The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. go.json http://purl.obolibrary.org/obo/GO_0003399 GO:0003398 biolink:BiologicalProcess glial cell differentiation involved in amphid sensory organ development The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ. go.json http://purl.obolibrary.org/obo/GO_0003398 GO:0003395 biolink:BiologicalProcess neuron migration involved in dendrite retrograde extension The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite. go.json http://purl.obolibrary.org/obo/GO_0003395 GO:0003394 biolink:BiologicalProcess cell adhesion involved in dendrite retrograde extension The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite. go.json http://purl.obolibrary.org/obo/GO_0003394 GO:0003397 biolink:BiologicalProcess neuron migration involved in amphid sensory organ dendrite retrograde extension The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ. go.json http://purl.obolibrary.org/obo/GO_0003397 GO:0003396 biolink:BiologicalProcess cell adhesion involved in amphid sensory organ dendrite retrograde extension The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ. go.json http://purl.obolibrary.org/obo/GO_0003396 GO:0003391 biolink:BiologicalProcess amphid sensory organ dendrite retrograde extension The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point. go.json http://purl.obolibrary.org/obo/GO_0003391 GO:0003390 biolink:BiologicalProcess dendrite development by retrograde extension The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point. go.json dendrite retrograde extension http://purl.obolibrary.org/obo/GO_0003390 GO:0003393 biolink:BiologicalProcess neuron migration involved in retrograde extension The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension. go.json http://purl.obolibrary.org/obo/GO_0003393 GO:0003392 biolink:BiologicalProcess cell adhesion involved in retrograde extension The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension. go.json http://purl.obolibrary.org/obo/GO_0003392 GO:0003377 biolink:BiologicalProcess obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis. go.json regulation of apoptosis by sphingolipid signaling pathway|regulation of apoptosis by sphingolipid signalling pathway True http://purl.obolibrary.org/obo/GO_0003377 GO:0003376 biolink:BiologicalProcess sphingosine-1-phosphate receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json S1P receptor signaling pathway|S1P signaling pathway|S1P-activated G-protein coupled receptor signaling pathway|S1P-activated GPCR signaling pathway|S1P-stimulated signal transduction pathway|sphingolipid signaling pathway|sphingolipid signalling pathway http://purl.obolibrary.org/obo/GO_0003376 GO:0003379 biolink:BiologicalProcess establishment of cell polarity involved in gastrulation cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. go.json http://purl.obolibrary.org/obo/GO_0003379 GO:0003378 biolink:BiologicalProcess obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response. go.json regulation of inflammatory response by sphingolipid signaling pathway|regulation of inflammatory response by sphingolipid signalling pathway True http://purl.obolibrary.org/obo/GO_0003378 GO:0003373 biolink:BiologicalProcess obsolete dynamin family protein polymerization involved in membrane fission OBSOLETE. The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission. go.json True http://purl.obolibrary.org/obo/GO_0003373 GO:0003372 biolink:BiologicalProcess establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell. go.json http://purl.obolibrary.org/obo/GO_0003372 GO:0003375 biolink:BiologicalProcess obsolete obsolete regulation of dynamin family protein polymerization involved in membrane fission OBSOLETE. OBSOLETE. Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission. go.json True http://purl.obolibrary.org/obo/GO_0003375 GO:0003374 biolink:BiologicalProcess obsolete dynamin family protein polymerization involved in mitochondrial fission OBSOLETE. The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission. go.json True http://purl.obolibrary.org/obo/GO_0003374 GO:0003371 biolink:BiologicalProcess establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. go.json http://purl.obolibrary.org/obo/GO_0003371 GO:0003370 biolink:BiologicalProcess cell-cell adhesion involved in mesendodermal cell migration The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm. go.json http://purl.obolibrary.org/obo/GO_0003370 GO:0003388 biolink:BiologicalProcess neuron development involved in amphid sensory organ development The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ. go.json http://purl.obolibrary.org/obo/GO_0003388 GO:0003387 biolink:BiologicalProcess neuron differentiation involved in amphid sensory organ development The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland. go.json http://purl.obolibrary.org/obo/GO_0003387 GO:0003389 biolink:BiologicalProcess retrograde extension The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point. go.json http://purl.obolibrary.org/obo/GO_0003389 GO:0003384 biolink:BiologicalProcess apical constriction involved in gastrulation The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0003384 GO:0003383 biolink:BiologicalProcess apical constriction The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell. go.json http://purl.obolibrary.org/obo/GO_0003383 GO:0003386 biolink:BiologicalProcess amphid sensory organ development The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes. go.json http://purl.obolibrary.org/obo/GO_0003386 GO:0003385 biolink:BiologicalProcess cell-cell signaling involved in amphid sensory organ development Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state. go.json cell-cell signalling involved in amphid sensory organ development http://purl.obolibrary.org/obo/GO_0003385 GO:0003380 biolink:BiologicalProcess establishment or maintenance of cytoskeleton polarity involved in gastrulation Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. go.json http://purl.obolibrary.org/obo/GO_0003380 GO:0003382 biolink:BiologicalProcess epithelial cell morphogenesis The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. go.json http://purl.obolibrary.org/obo/GO_0003382 GO:0003381 biolink:BiologicalProcess epithelial cell morphogenesis involved in gastrulation The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0003381 GO:0003359 biolink:BiologicalProcess noradrenergic neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron. go.json norepinephrine secreting neuron fate commitment http://purl.obolibrary.org/obo/GO_0003359 GO:0003358 biolink:BiologicalProcess noradrenergic neuron development The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. go.json norepinephrine secreting neuron development http://purl.obolibrary.org/obo/GO_0003358 GO:0003355 biolink:BiologicalProcess cilium movement involved in otolith formation The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles. go.json http://purl.obolibrary.org/obo/GO_0003355 GO:0003354 biolink:BiologicalProcess negative regulation of cilium movement Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. go.json negative regulation of flagellum movement|negative regulation of microtubule-based flagellum movement http://purl.obolibrary.org/obo/GO_0003354 GO:0003357 biolink:BiologicalProcess noradrenergic neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. go.json norepinephrine secreting neuron differentiation http://purl.obolibrary.org/obo/GO_0003357 GO:0003356 biolink:BiologicalProcess regulation of cilium beat frequency Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium. go.json regulation of flagellum beat frequency|regulation of microtubule-based flagellum beat frequency http://purl.obolibrary.org/obo/GO_0003356 GO:0003351 biolink:BiologicalProcess epithelial cilium movement involved in extracellular fluid movement The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid. go.json cilium movement involved in fluid flow|epithelial cilium beating http://purl.obolibrary.org/obo/GO_0003351 GO:0003350 biolink:BiologicalProcess pulmonary myocardium development The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein. go.json http://purl.obolibrary.org/obo/GO_0003350 GO:0003353 biolink:BiologicalProcess positive regulation of cilium movement Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. go.json positive regulation of flagellar movement|positive regulation of flagellum movement|positive regulation of microtubule-based flagellum movement http://purl.obolibrary.org/obo/GO_0003353 GO:0003352 biolink:BiologicalProcess regulation of cilium movement Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. go.json regulation of flagellar movement|regulation of flagellum movement|regulation of microtubule-based flagellum movement http://purl.obolibrary.org/obo/GO_0003352 GO:0003369 biolink:BiologicalProcess establishment of cell polarity involved in mesendodermal cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell. go.json http://purl.obolibrary.org/obo/GO_0003369 GO:0003366 biolink:BiologicalProcess cell-matrix adhesion involved in ameboidal cell migration The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell. go.json http://purl.obolibrary.org/obo/GO_0003366 GO:0003365 biolink:BiologicalProcess establishment of cell polarity involved in ameboidal cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. go.json http://purl.obolibrary.org/obo/GO_0003365 GO:0003368 biolink:BiologicalProcess cell-matrix adhesion involved in mesendodermal cell migration The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell. go.json http://purl.obolibrary.org/obo/GO_0003368 GO:0003367 biolink:BiologicalProcess cell-cell adhesion involved in ameboidal cell migration The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells. go.json http://purl.obolibrary.org/obo/GO_0003367 GO:0003362 biolink:BiologicalProcess noradrenergic neuron fate commitment involved in brainstem development The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem. go.json http://purl.obolibrary.org/obo/GO_0003362 GO:0003361 biolink:BiologicalProcess noradrenergic neuron differentiation involved in brainstem development The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem. go.json http://purl.obolibrary.org/obo/GO_0003361 GO:0003364 biolink:BiologicalProcess lamellipodium assembly involved in mesendodermal cell migration Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell. go.json http://purl.obolibrary.org/obo/GO_0003364 GO:0003363 biolink:BiologicalProcess lamellipodium assembly involved in ameboidal cell migration Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell. go.json http://purl.obolibrary.org/obo/GO_0003363 GO:0003360 biolink:BiologicalProcess brainstem development The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. go.json http://purl.obolibrary.org/obo/GO_0003360 GO:0003337 biolink:BiologicalProcess mesenchymal to epithelial transition involved in metanephros morphogenesis A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. go.json metanephric mesenchyme to epithelial transition http://purl.obolibrary.org/obo/GO_0003337 GO:0003336 biolink:BiologicalProcess corneocyte desquamation The delamination process that results in the shedding of a corneocyte from the surface of the epidermis. go.json epidermal desquamation http://purl.obolibrary.org/obo/GO_0003336 GO:0003339 biolink:BiologicalProcess regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0003339 GO:0003338 biolink:BiologicalProcess metanephros morphogenesis The process in which the anatomical structures of the metanephros are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003338 GO:0003333 biolink:BiologicalProcess amino acid transmembrane transport The process in which an amino acid is transported across a membrane. go.json amino acid membrane transport http://purl.obolibrary.org/obo/GO_0003333 GO:0003332 biolink:BiologicalProcess negative regulation of extracellular matrix constituent secretion Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. go.json http://purl.obolibrary.org/obo/GO_0003332 GO:0003335 biolink:BiologicalProcess corneocyte development The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis. go.json http://purl.obolibrary.org/obo/GO_0003335 GO:0003334 biolink:BiologicalProcess keratinocyte development The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0003334 GO:0003331 biolink:BiologicalProcess positive regulation of extracellular matrix constituent secretion Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. go.json http://purl.obolibrary.org/obo/GO_0003331 GO:0003330 biolink:BiologicalProcess regulation of extracellular matrix constituent secretion Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. go.json http://purl.obolibrary.org/obo/GO_0003330 GO:0160090 biolink:MolecularActivity internal mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine. go.json http://purl.obolibrary.org/obo/GO_0160090 GO:0042901 biolink:MolecularActivity arabinan transmembrane transporter activity Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042901 GO:0042900 biolink:MolecularActivity arabinose transmembrane transporter activity Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042900 GO:0042903 biolink:MolecularActivity tubulin deacetylase activity Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. Reactome:R-HSA-5618331 go.json http://purl.obolibrary.org/obo/GO_0042903 GO:0160092 biolink:CellularComponent hemozoin formation complex A protein-containing complex involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage of a Plasmodium. It is composed of at least falcipains FP2A and/or FP2B, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN. go.json http://purl.obolibrary.org/obo/GO_0160092 GO:0160091 biolink:BiologicalProcess spliceosome-depend formation of circular RNA Formation of circular RNAs (circRNAs) by back-splicing circularization of pre-mRNAs in a spliceosome-dependent process. go.json http://purl.obolibrary.org/obo/GO_0160091 GO:0042902 biolink:BiologicalProcess peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. RESID:AA0345 go.json http://purl.obolibrary.org/obo/GO_0042902 gocheck_do_not_annotate GO:0042909 biolink:BiologicalProcess obsolete acridine transport OBSOLETE. The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json True http://purl.obolibrary.org/obo/GO_0042909 GO:0042908 biolink:BiologicalProcess xenobiotic transport The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json drug transport http://purl.obolibrary.org/obo/GO_0042908 goslim_pir GO:0160097 biolink:MolecularActivity reverse gyrase activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle, is driven by ATP hydrolysis. WIKIPEDIA:Reverse_gyrase go.json http://purl.obolibrary.org/obo/GO_0160097 GO:0160094 biolink:BiologicalProcess nematode pharynx development The process whose specific outcome is the progression of nematode pharynx over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0160094 GO:0042905 biolink:BiologicalProcess 9-cis-retinoic acid metabolic process The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative. go.json 9-cis-retinoic acid metabolism http://purl.obolibrary.org/obo/GO_0042905 GO:0042904 biolink:BiologicalProcess 9-cis-retinoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. go.json 9-cis-retinoic acid anabolism|9-cis-retinoic acid biosynthesis|9-cis-retinoic acid formation|9-cis-retinoic acid synthesis http://purl.obolibrary.org/obo/GO_0042904 GO:0160093 biolink:BiologicalProcess chordate pharynx development The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0160093 GO:0042907 biolink:MolecularActivity xanthine transmembrane transporter activity Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. go.json http://purl.obolibrary.org/obo/GO_0042907 GO:0160096 biolink:BiologicalProcess nematode pharyngeal muscle development The process whose specific outcome is the progression of the nematode pharyngeal muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0160096 GO:0160095 biolink:BiologicalProcess insect pharynx development The process whose specific outcome is the progression of insect pharynx over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0160095 GO:0042906 biolink:BiologicalProcess xanthine transport The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. go.json xanthine transmembrane transport http://purl.obolibrary.org/obo/GO_0042906 GO:0003348 biolink:BiologicalProcess cardiac endothelial cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0003348 GO:0003347 biolink:BiologicalProcess epicardial cell to mesenchymal cell transition A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium. go.json http://purl.obolibrary.org/obo/GO_0003347 GO:0003349 biolink:BiologicalProcess epicardium-derived cardiac endothelial cell differentiation The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. go.json http://purl.obolibrary.org/obo/GO_0003349 GO:0003344 biolink:BiologicalProcess pericardium morphogenesis The process in which the anatomical structure of the pericardium is generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003344 GO:0003343 biolink:BiologicalProcess septum transversum development The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. go.json http://purl.obolibrary.org/obo/GO_0003343 GO:0003346 biolink:BiologicalProcess epicardium-derived cell migration to the myocardium The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium. go.json http://purl.obolibrary.org/obo/GO_0003346 GO:0003345 biolink:BiologicalProcess proepicardium cell migration involved in pericardium morphogenesis The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart. go.json http://purl.obolibrary.org/obo/GO_0003345 GO:0003340 biolink:BiologicalProcess negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. go.json http://purl.obolibrary.org/obo/GO_0003340 GO:0003342 biolink:BiologicalProcess proepicardium development The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. go.json http://purl.obolibrary.org/obo/GO_0003342 GO:0003341 biolink:BiologicalProcess cilium movement The directed, self-propelled movement of a cilium. go.json ciliary motility|cilium beating|flagellar motility|flagellar movement|flagellum movement|microtubule-based flagellum movement http://purl.obolibrary.org/obo/GO_0003341 GO:0042912 biolink:MolecularActivity colicin transmembrane transporter activity Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. go.json http://purl.obolibrary.org/obo/GO_0042912 GO:0042911 biolink:MolecularActivity obsolete acridine transmembrane transporter activity OBSOLETE. Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene from one side of a membrane to the other. go.json acridine transporter activity True http://purl.obolibrary.org/obo/GO_0042911 GO:0042914 biolink:BiologicalProcess colicin transport The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. go.json http://purl.obolibrary.org/obo/GO_0042914 GO:0042913 biolink:MolecularActivity group A colicin transmembrane transporter activity Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0042913 GO:0042910 biolink:MolecularActivity xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. Reactome:R-HSA-5625574|Reactome:R-HSA-597628 go.json drug transmembrane transporter activity|drug transporter activity|multidrug efflux pump activity|multidrug transporter activity|multidrug, alkane resistant pump activity|xenobiotic transporter activity http://purl.obolibrary.org/obo/GO_0042910 goslim_metagenomics GO:0042919 biolink:BiologicalProcess benzoate transport The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042919 GO:0042916 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042916 GO:0042915 biolink:BiologicalProcess group A colicin transport The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042915 GO:0042918 biolink:BiologicalProcess alkanesulfonate transport The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. go.json alkanesulphonate transport http://purl.obolibrary.org/obo/GO_0042918 GO:0042917 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042917 GO:1904279 biolink:BiologicalProcess regulation of transcription by RNA polymerase V Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase V. go.json regulation of transcription from RNA pol V promoter|regulation of transcription from RNA polymerase V promoter http://purl.obolibrary.org/obo/GO_1904279 GO:1904278 biolink:BiologicalProcess positive regulation of wax biosynthetic process Any process that activates or increases the frequency, rate or extent of wax biosynthetic process. go.json activation of wax anabolism|activation of wax biosynthesis|activation of wax biosynthetic process|activation of wax formation|activation of wax synthesis|positive regulation of wax anabolism|positive regulation of wax biosynthesis|positive regulation of wax formation|positive regulation of wax synthesis|up regulation of wax anabolism|up regulation of wax biosynthesis|up regulation of wax biosynthetic process|up regulation of wax formation|up regulation of wax synthesis|up-regulation of wax anabolism|up-regulation of wax biosynthesis|up-regulation of wax biosynthetic process|up-regulation of wax formation|up-regulation of wax synthesis|upregulation of wax anabolism|upregulation of wax biosynthesis|upregulation of wax biosynthetic process|upregulation of wax formation|upregulation of wax synthesis http://purl.obolibrary.org/obo/GO_1904278 GO:1904288 biolink:MolecularActivity BAT3 complex binding Binding to a BAT3 complex. go.json BAG6-UBL4A-TRC35 complex binding|BAT3-TRC35-UBL4A complex binding|Bag6 complex binding http://purl.obolibrary.org/obo/GO_1904288 GO:1904287 biolink:BiologicalProcess positive regulation of protein-pyridoxal-5-phosphate linkage Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage. go.json activation of protein-pyridoxal-5-phosphate linkage|stimulation of protein-pyridoxal-5-phosphate linkage|up regulation of protein-pyridoxal-5-phosphate linkage|up-regulation of protein-pyridoxal-5-phosphate linkage|upregulation of protein-pyridoxal-5-phosphate linkage http://purl.obolibrary.org/obo/GO_1904287 GO:1904286 biolink:BiologicalProcess negative regulation of protein-pyridoxal-5-phosphate linkage Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage. go.json down regulation of protein-pyridoxal-5-phosphate linkage|down-regulation of protein-pyridoxal-5-phosphate linkage|downregulation of protein-pyridoxal-5-phosphate linkage|inhibition of protein-pyridoxal-5-phosphate linkage http://purl.obolibrary.org/obo/GO_1904286 GO:1904285 biolink:BiologicalProcess regulation of protein-pyridoxal-5-phosphate linkage Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage. go.json http://purl.obolibrary.org/obo/GO_1904285 GO:1904284 biolink:BiologicalProcess positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I Any process that activates or increases the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I. go.json activation of antigen processing and presentation of endogenous peptide antigen via MHC class I|activation of endogenous peptide antigen processing and presentation via MHC class I|positive regulation of endogenous peptide antigen processing and presentation via MHC class I|up regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|up regulation of endogenous peptide antigen processing and presentation via MHC class I|up-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|up-regulation of endogenous peptide antigen processing and presentation via MHC class I|upregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|upregulation of endogenous peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_1904284 GO:1904283 biolink:BiologicalProcess negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I. go.json down regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|down regulation of endogenous peptide antigen processing and presentation via MHC class I|down-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|down-regulation of endogenous peptide antigen processing and presentation via MHC class I|downregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|downregulation of endogenous peptide antigen processing and presentation via MHC class I|inhibition of antigen processing and presentation of endogenous peptide antigen via MHC class I|inhibition of endogenous peptide antigen processing and presentation via MHC class I|negative regulation of endogenous peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_1904283 GO:1904282 biolink:BiologicalProcess regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I Any process that modulates the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I. go.json regulation of antigen presentation, endogenous peptide antigen|regulation of antigen processing, endogenous antigen via MHC class I|regulation of antigen processing, endogenous antigen via major histocompatibility complex class I|regulation of endogenous peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_1904282 GO:1904281 biolink:BiologicalProcess positive regulation of transcription by RNA polymerase V Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase V. go.json activation of transcription from RNA pol V promoter|activation of transcription from RNA polymerase V promoter|positive regulation of transcription from RNA pol V promoter|positive regulation of transcription from RNA polymerase V promoter|up regulation of transcription from RNA pol V promoter|up regulation of transcription from RNA polymerase V promoter|up-regulation of transcription from RNA pol V promoter|up-regulation of transcription from RNA polymerase V promoter|upregulation of transcription from RNA pol V promoter|upregulation of transcription from RNA polymerase V promoter http://purl.obolibrary.org/obo/GO_1904281 GO:1904280 biolink:BiologicalProcess negative regulation of transcription by RNA polymerase V Any process that stops, prevents or reduces the frequency, rate or extent of transcription mediated by RNA polymerase V. go.json down regulation of transcription from RNA pol V promoter|down regulation of transcription from RNA polymerase V promoter|down-regulation of transcription from RNA pol V promoter|down-regulation of transcription from RNA polymerase V promoter|downregulation of transcription from RNA pol V promoter|downregulation of transcription from RNA polymerase V promoter|inhibition of transcription from RNA pol V promoter|inhibition of transcription from RNA polymerase V promoter|negative regulation of transcription from RNA pol V promoter|negative regulation of transcription from RNA polymerase V promoter http://purl.obolibrary.org/obo/GO_1904280 GO:1904289 biolink:BiologicalProcess regulation of mitotic DNA damage checkpoint Any process that modulates the frequency, rate or extent of mitotic DNA damage checkpoint. go.json http://purl.obolibrary.org/obo/GO_1904289 GO:1904299 biolink:BiologicalProcess negative regulation of transcytosis Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis. go.json down regulation of transcytosis|down-regulation of transcytosis|downregulation of transcytosis|inhibition of transcytosis http://purl.obolibrary.org/obo/GO_1904299 GO:1904298 biolink:BiologicalProcess regulation of transcytosis Any process that modulates the frequency, rate or extent of transcytosis. go.json http://purl.obolibrary.org/obo/GO_1904298 GO:1904297 biolink:BiologicalProcess positive regulation of osmolarity-sensing cation channel activity Any process that activates or increases the frequency, rate or extent of osmolarity-sensing cation channel activity. go.json activation of osmolarity-sensing cation channel activity|up regulation of osmolarity-sensing cation channel activity|up-regulation of osmolarity-sensing cation channel activity|upregulation of osmolarity-sensing cation channel activity http://purl.obolibrary.org/obo/GO_1904297 gocheck_do_not_annotate GO:1904296 biolink:BiologicalProcess negative regulation of osmolarity-sensing cation channel activity Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity. go.json down regulation of osmolarity-sensing cation channel activity|down-regulation of osmolarity-sensing cation channel activity|downregulation of osmolarity-sensing cation channel activity|inhibition of osmolarity-sensing cation channel activity http://purl.obolibrary.org/obo/GO_1904296 gocheck_do_not_annotate GO:1904295 biolink:BiologicalProcess regulation of osmolarity-sensing cation channel activity Any process that modulates the frequency, rate or extent of osmolarity-sensing cation channel activity. go.json http://purl.obolibrary.org/obo/GO_1904295 gocheck_do_not_annotate GO:1904294 biolink:BiologicalProcess positive regulation of ERAD pathway Any process that activates or increases the frequency, rate or extent of ERAD pathway. go.json activation of ER-associated degradation pathway|activation of ERAD pathway|activation of endoplasmic reticulum-associated degradation|activation of endoplasmic reticulum-associated protein degradation pathway|positive regulation of ER-associated degradation pathway|positive regulation of endoplasmic reticulum-associated degradation|positive regulation of endoplasmic reticulum-associated protein degradation pathway|up regulation of ER-associated degradation pathway|up regulation of ERAD pathway|up regulation of endoplasmic reticulum-associated degradation|up regulation of endoplasmic reticulum-associated protein degradation pathway|up-regulation of ER-associated degradation pathway|up-regulation of ERAD pathway|up-regulation of endoplasmic reticulum-associated degradation|up-regulation of endoplasmic reticulum-associated protein degradation pathway|upregulation of ER-associated degradation pathway|upregulation of ERAD pathway|upregulation of endoplasmic reticulum-associated degradation|upregulation of endoplasmic reticulum-associated protein degradation pathway http://purl.obolibrary.org/obo/GO_1904294 GO:1904293 biolink:BiologicalProcess negative regulation of ERAD pathway Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. go.json down regulation of ER-associated degradation pathway|down regulation of ERAD pathway|down regulation of endoplasmic reticulum-associated degradation|down regulation of endoplasmic reticulum-associated protein degradation pathway|down-regulation of ER-associated degradation pathway|down-regulation of ERAD pathway|down-regulation of endoplasmic reticulum-associated degradation|down-regulation of endoplasmic reticulum-associated protein degradation pathway|downregulation of ER-associated degradation pathway|downregulation of ERAD pathway|downregulation of endoplasmic reticulum-associated degradation|downregulation of endoplasmic reticulum-associated protein degradation pathway|inhibition of ER-associated degradation pathway|inhibition of ERAD pathway|inhibition of endoplasmic reticulum-associated degradation|inhibition of endoplasmic reticulum-associated protein degradation pathway|negative regulation of ER-associated degradation pathway|negative regulation of endoplasmic reticulum-associated degradation|negative regulation of endoplasmic reticulum-associated protein degradation pathway http://purl.obolibrary.org/obo/GO_1904293 GO:1904292 biolink:BiologicalProcess regulation of ERAD pathway Any process that modulates the frequency, rate or extent of ERAD pathway. go.json regulation of ER-associated degradation pathway|regulation of endoplasmic reticulum-associated degradation|regulation of endoplasmic reticulum-associated protein degradation pathway http://purl.obolibrary.org/obo/GO_1904292 GO:1904291 biolink:BiologicalProcess positive regulation of mitotic DNA damage checkpoint Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint. go.json activation of mitotic DNA damage checkpoint|up regulation of mitotic DNA damage checkpoint|up-regulation of mitotic DNA damage checkpoint|upregulation of mitotic DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1904291 GO:1904290 biolink:BiologicalProcess negative regulation of mitotic DNA damage checkpoint Any process that stops, prevents or reduces the frequency, rate or extent of mitotic DNA damage checkpoint. go.json down regulation of mitotic DNA damage checkpoint|down-regulation of mitotic DNA damage checkpoint|downregulation of mitotic DNA damage checkpoint|inhibition of mitotic DNA damage checkpoint http://purl.obolibrary.org/obo/GO_1904290 GO:0052447 biolink:BiologicalProcess obsolete modulation by organism of symbiont ethylene-mediated defense response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont ethylene-mediated defense response True http://purl.obolibrary.org/obo/GO_0052447 GO:0052446 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont cell wall thickening OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont cell wall thickening|modulation by organism of symbiont defensive cell wall thickening True http://purl.obolibrary.org/obo/GO_0052446 GO:0052445 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052445 GO:0052444 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway|modulation of defense-related symbiont SA-mediated signal transduction pathway by organism True http://purl.obolibrary.org/obo/GO_0052444 GO:0052449 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052449 GO:0052448 biolink:BiologicalProcess obsolete modulation by organism of ethylene levels in symbiont OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of ethylene levels in symbiont True http://purl.obolibrary.org/obo/GO_0052448 GO:1904200 biolink:BiologicalProcess iodide transmembrane transport The process in which iodide is transported across a membrane. go.json http://purl.obolibrary.org/obo/GO_1904200 GO:0052443 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052443 GO:0052442 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway|modulation of defense-related symbiont JA-mediated signal transduction pathway by organism True http://purl.obolibrary.org/obo/GO_0052442 GO:0052441 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052441 GO:0052440 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052440 GO:0052458 biolink:BiologicalProcess obsolete modulation by organism of symbiont non-apoptotic programmed cell death OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont non-apoptotic programmed cell death True http://purl.obolibrary.org/obo/GO_0052458 GO:0052457 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont nitric oxide production OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont NO production|modulation by organism of defense-related symbiont nitric oxide production True http://purl.obolibrary.org/obo/GO_0052457 GO:0052456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052456 GO:0052455 biolink:BiologicalProcess obsolete modulation by organism of jasmonic acid levels in symbiont OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of jasmonic acid levels in symbiont True http://purl.obolibrary.org/obo/GO_0052455 GO:0052459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052459 GO:1904209 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904209 GO:1904208 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904208 GO:1904207 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904207 GO:1904206 biolink:BiologicalProcess positive regulation of skeletal muscle hypertrophy Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. go.json activation of skeletal muscle hypertrophy|up regulation of skeletal muscle hypertrophy|up-regulation of skeletal muscle hypertrophy|upregulation of skeletal muscle hypertrophy http://purl.obolibrary.org/obo/GO_1904206 GO:1904205 biolink:BiologicalProcess negative regulation of skeletal muscle hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. go.json down regulation of skeletal muscle hypertrophy|down-regulation of skeletal muscle hypertrophy|downregulation of skeletal muscle hypertrophy|inhibition of skeletal muscle hypertrophy http://purl.obolibrary.org/obo/GO_1904205 GO:1904204 biolink:BiologicalProcess regulation of skeletal muscle hypertrophy Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. go.json http://purl.obolibrary.org/obo/GO_1904204 GO:1904203 biolink:BiologicalProcess positive regulation of iodide transport Any process that activates or increases the frequency, rate or extent of iodide transport. go.json activation of iodide transport|up regulation of iodide transport|up-regulation of iodide transport|upregulation of iodide transport http://purl.obolibrary.org/obo/GO_1904203 GO:1904202 biolink:BiologicalProcess negative regulation of iodide transport Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport. go.json down regulation of iodide transport|down-regulation of iodide transport|downregulation of iodide transport|inhibition of iodide transport http://purl.obolibrary.org/obo/GO_1904202 GO:1904201 biolink:BiologicalProcess regulation of iodide transport Any process that modulates the frequency, rate or extent of iodide transport. go.json http://purl.obolibrary.org/obo/GO_1904201 GO:1904211 biolink:BiologicalProcess membrane protein proteolysis involved in retrograde protein transport, ER to cytosol Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol. go.json intramembrane cleavage of ERAD substrate|intramembrane proteolysis involved in ERAD|membrane protein proteolysis involved in protein dislocation from ER|membrane protein proteolysis involved in protein retrotranslocation, ER to cytosol|membrane protein proteolysis involved in retrograde protein transport, endoplasmic reticulum to cytosol http://purl.obolibrary.org/obo/GO_1904211 GO:1904210 biolink:BiologicalProcess VCP-NPL4-UFD1 AAA ATPase complex assembly The aggregation, arrangement and bonding together of a set of components to form a VCP-NPL4-UFD1 AAA ATPase complex. go.json Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|VCP-NPL4-UFD1 AAA ATPase complex formation|p97-Ufd1-Npl4 complex assembly|p97-Ufd1-Npl4 complex formation http://purl.obolibrary.org/obo/GO_1904210 GO:0052450 biolink:BiologicalProcess obsolete modulation by organism of induced systemic resistance in symbiont OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of induced systemic resistance in symbiont True http://purl.obolibrary.org/obo/GO_0052450 GO:0052454 biolink:BiologicalProcess obsolete modulation by organism of symbiont jasmonic acid-mediated defense response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont JA-mediated defense response|modulation by organism of symbiont jasmonic acid-mediated defense response True http://purl.obolibrary.org/obo/GO_0052454 GO:0052453 biolink:BiologicalProcess obsolete modulation by organism of symbiont intracellular transport OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont intracellular transport|modulation of symbiont intracellular trafficking True http://purl.obolibrary.org/obo/GO_0052453 GO:0052452 biolink:BiologicalProcess obsolete modulation by organism of symbiont innate immunity OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont innate immunity|modulation of symbiont innate immune response True http://purl.obolibrary.org/obo/GO_0052452 GO:0052451 biolink:BiologicalProcess obsolete modulation by organism of symbiont inflammatory response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont inflammatory response True http://purl.obolibrary.org/obo/GO_0052451 GO:0052469 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052469 GO:0052468 biolink:BiologicalProcess obsolete modulation by organism of salicylic acid levels in symbiont OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of salicylic acid levels in symbiont True http://purl.obolibrary.org/obo/GO_0052468 GO:0052467 biolink:BiologicalProcess obsolete modulation by organism of symbiont salicylic acid-mediated defense response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont SA-mediated defense response|modulation by organism of symbiont salicylic acid-mediated defense response True http://purl.obolibrary.org/obo/GO_0052467 GO:0052466 biolink:BiologicalProcess obsolete modulation by organism of symbiont resistance gene-dependent defense response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense response in symbiont by specific elicitors|modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont|modulation by organism of symbiont gene-for-gene resistance|modulation by organism of symbiont resistance gene-dependent defense response True http://purl.obolibrary.org/obo/GO_0052466 GO:1904219 biolink:BiologicalProcess positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity. go.json activation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|activation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|activation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|activation of CDP-diglyceride-L-serine phosphatidyltransferase activity|activation of CDP-diglyceride:serine phosphatidyltransferase activity|activation of CDP-diglycerine-serine O-phosphatidyltransferase activity|activation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|activation of CDPdiglyceride-serine O-phosphatidyltransferase activity|activation of PS synthase activity|activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|activation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|activation of phosphatidylserine synthase activity|activation of phosphatidylserine synthetase activity|positive regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|positive regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|positive regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|positive regulation of CDP-diglyceride:serine phosphatidyltransferase activity|positive regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|positive regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|positive regulation of PS synthase activity|positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|positive regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|positive regulation of phosphatidylserine synthase activity|positive regulation of phosphatidylserine synthetase activity|up regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|up regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|up regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|up regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|up regulation of CDP-diglyceride:serine phosphatidyltransferase activity|up regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|up regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|up regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|up regulation of PS synthase activity|up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|up regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|up regulation of phosphatidylserine synthase activity|up regulation of phosphatidylserine synthetase activity|up-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|up-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|up-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|up-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|up-regulation of CDP-diglyceride:serine phosphatidyltransferase activity|up-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|up-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|up-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|up-regulation of PS synthase activity|up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|up-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|up-regulation of phosphatidylserine synthase activity|up-regulation of phosphatidylserine synthetase activity|upregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|upregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|upregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|upregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|upregulation of CDP-diglyceride:serine phosphatidyltransferase activity|upregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|upregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|upregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|upregulation of PS synthase activity|upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|upregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|upregulation of phosphatidylserine synthase activity|upregulation of phosphatidylserine synthetase activity http://purl.obolibrary.org/obo/GO_1904219 gocheck_do_not_annotate GO:1904218 biolink:BiologicalProcess negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity. go.json down regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|down regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|down regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|down regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|down regulation of CDP-diglyceride:serine phosphatidyltransferase activity|down regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|down regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|down regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|down regulation of PS synthase activity|down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|down regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|down regulation of phosphatidylserine synthase activity|down regulation of phosphatidylserine synthetase activity|down-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|down-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|down-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|down-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|down-regulation of CDP-diglyceride:serine phosphatidyltransferase activity|down-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|down-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|down-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|down-regulation of PS synthase activity|down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|down-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|down-regulation of phosphatidylserine synthase activity|down-regulation of phosphatidylserine synthetase activity|downregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|downregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|downregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|downregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|downregulation of CDP-diglyceride:serine phosphatidyltransferase activity|downregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|downregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|downregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|downregulation of PS synthase activity|downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|downregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|downregulation of phosphatidylserine synthase activity|downregulation of phosphatidylserine synthetase activity|inhibition of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|inhibition of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|inhibition of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|inhibition of CDP-diglyceride-L-serine phosphatidyltransferase activity|inhibition of CDP-diglyceride:serine phosphatidyltransferase activity|inhibition of CDP-diglycerine-serine O-phosphatidyltransferase activity|inhibition of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|inhibition of CDPdiglyceride-serine O-phosphatidyltransferase activity|inhibition of PS synthase activity|inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|inhibition of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|inhibition of phosphatidylserine synthase activity|inhibition of phosphatidylserine synthetase activity|negative regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|negative regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|negative regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|negative regulation of CDP-diglyceride:serine phosphatidyltransferase activity|negative regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|negative regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|negative regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|negative regulation of PS synthase activity|negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|negative regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|negative regulation of phosphatidylserine synthase activity|negative regulation of phosphatidylserine synthetase activity http://purl.obolibrary.org/obo/GO_1904218 gocheck_do_not_annotate GO:1904217 biolink:BiologicalProcess regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Any process that modulates the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity. go.json regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity|regulation of CDP-diglyceride:serine phosphatidyltransferase activity|regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity|regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity|regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity|regulation of PS synthase activity|regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|regulation of phosphatidylserine synthase activity|regulation of phosphatidylserine synthetase activity|regulation of serine exchange enzyme http://purl.obolibrary.org/obo/GO_1904217 gocheck_do_not_annotate GO:1904216 biolink:BiologicalProcess positive regulation of protein import into chloroplast stroma Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma. go.json activation of chloroplast stroma protein import|activation of protein import into chloroplast stroma|activation of protein transport into chloroplast stroma|positive regulation of chloroplast stroma protein import|positive regulation of protein transport into chloroplast stroma|up regulation of chloroplast stroma protein import|up regulation of protein import into chloroplast stroma|up regulation of protein transport into chloroplast stroma|up-regulation of chloroplast stroma protein import|up-regulation of protein import into chloroplast stroma|up-regulation of protein transport into chloroplast stroma|upregulation of chloroplast stroma protein import|upregulation of protein import into chloroplast stroma|upregulation of protein transport into chloroplast stroma http://purl.obolibrary.org/obo/GO_1904216 GO:1904215 biolink:BiologicalProcess regulation of protein import into chloroplast stroma Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma. go.json regulation of chloroplast stroma protein import|regulation of protein transport into chloroplast stroma http://purl.obolibrary.org/obo/GO_1904215 GO:1904214 biolink:BiologicalProcess positive regulation of iodide transmembrane transport Any process that activates or increases the frequency, rate or extent of iodide transmembrane transport. go.json activation of iodide transmembrane transport|up regulation of iodide transmembrane transport|up-regulation of iodide transmembrane transport|upregulation of iodide transmembrane transport http://purl.obolibrary.org/obo/GO_1904214 GO:1904213 biolink:BiologicalProcess negative regulation of iodide transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of iodide transmembrane transport. go.json down regulation of iodide transmembrane transport|down-regulation of iodide transmembrane transport|downregulation of iodide transmembrane transport|inhibition of iodide transmembrane transport http://purl.obolibrary.org/obo/GO_1904213 GO:1904212 biolink:BiologicalProcess regulation of iodide transmembrane transport Any process that modulates the frequency, rate or extent of iodide transmembrane transport. go.json http://purl.obolibrary.org/obo/GO_1904212 GO:1904222 biolink:BiologicalProcess positive regulation of serine C-palmitoyltransferase activity Any process that activates or increases the frequency, rate or extent of serine C-palmitoyltransferase activity. go.json activation of 3-oxosphinganine synthetase activity|activation of SPT|activation of acyl-CoA:serine C-2 acyltransferase decarboxylating|activation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|activation of serine C-palmitoyltransferase activity|positive regulation of 3-oxosphinganine synthetase activity|positive regulation of SPT|positive regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|positive regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|up regulation of 3-oxosphinganine synthetase activity|up regulation of SPT|up regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|up regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|up regulation of serine C-palmitoyltransferase activity|up-regulation of 3-oxosphinganine synthetase activity|up-regulation of SPT|up-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|up-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|up-regulation of serine C-palmitoyltransferase activity|upregulation of 3-oxosphinganine synthetase activity|upregulation of SPT|upregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|upregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|upregulation of serine C-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_1904222 gocheck_do_not_annotate GO:1904221 biolink:BiologicalProcess negative regulation of serine C-palmitoyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity. go.json down regulation of 3-oxosphinganine synthetase activity|down regulation of SPT|down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|down regulation of serine C-palmitoyltransferase activity|down-regulation of 3-oxosphinganine synthetase activity|down-regulation of SPT|down-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|down-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|down-regulation of serine C-palmitoyltransferase activity|downregulation of 3-oxosphinganine synthetase activity|downregulation of SPT|downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|downregulation of serine C-palmitoyltransferase activity|inhibition of 3-oxosphinganine synthetase activity|inhibition of SPT|inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating|inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|inhibition of serine C-palmitoyltransferase activity|negative regulation of 3-oxosphinganine synthetase activity|negative regulation of SPT|negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity http://purl.obolibrary.org/obo/GO_1904221 gocheck_do_not_annotate GO:1904220 biolink:BiologicalProcess regulation of serine C-palmitoyltransferase activity Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity. go.json regulation of 3-oxosphinganine synthetase activity|regulation of SPT|regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating|regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity|regulation of serine palmitoyltransferase http://purl.obolibrary.org/obo/GO_1904220 gocheck_do_not_annotate GO:0052461 biolink:BiologicalProcess obsolete modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity OBSOLETE. This term was not defined before being made obsolete. go.json modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity True http://purl.obolibrary.org/obo/GO_0052461 GO:0052460 biolink:BiologicalProcess modulation of nutrient release by symbiont Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by host of nutrient release from symbiont http://purl.obolibrary.org/obo/GO_0052460 GO:0052465 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont reactive oxygen species production OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont AOS production|modulation by organism of defense-related symbiont ROI production|modulation by organism of defense-related symbiont ROS production|modulation by organism of defense-related symbiont active oxygen species production|modulation by organism of defense-related symbiont metabolic burst|modulation by organism of defense-related symbiont oxidative burst|modulation by organism of defense-related symbiont reactive oxidative species production|modulation by organism of defense-related symbiont reactive oxygen intermediate production|modulation by organism of defense-related symbiont reactive oxygen species production|modulation by organism of defense-related symbiont respiratory burst True http://purl.obolibrary.org/obo/GO_0052465 GO:0052464 biolink:BiologicalProcess obsolete modulation by organism of symbiont programmed cell death OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont programmed cell death|modulation of symbiont HR|modulation of symbiont PCD|modulation of symbiont hypersensitive response True http://purl.obolibrary.org/obo/GO_0052464 GO:0052463 biolink:BiologicalProcess obsolete modulation by organism of symbiont phytoalexin production OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont phytoalexin production True http://purl.obolibrary.org/obo/GO_0052463 GO:0052462 biolink:BiologicalProcess obsolete modulation by host of symbiont phagocytosis OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052462 GO:0052479 biolink:BiologicalProcess obsolete negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway|suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052479 GO:0052478 biolink:BiologicalProcess obsolete negative regulation by organism of defense-related symbiont cell wall callose deposition OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of defense-related symbiont cell wall callose deposition True http://purl.obolibrary.org/obo/GO_0052478 GO:0052477 biolink:BiologicalProcess obsolete negative regulation by organism of defense-related symbiont callose deposition OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of defense-related symbiont callose deposition|suppression by organism of defense-related symbiont callose deposition True http://purl.obolibrary.org/obo/GO_0052477 GO:1904229 biolink:BiologicalProcess regulation of succinate dehydrogenase activity Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity. go.json regulation of fumarate dehydrogenase activity|regulation of fumarate reductase activity|regulation of fumaric hydrogenase activity|regulation of succinate oxidoreductase activity|regulation of succinate:(acceptor) oxidoreductase activity|regulation of succinate:acceptor oxidoreductase activity|regulation of succinic acid dehydrogenase activity|regulation of succinic dehydrogenase activity|regulation of succinodehydrogenase activity|regulation of succinyl dehydrogenase activity http://purl.obolibrary.org/obo/GO_1904229 gocheck_do_not_annotate GO:1904228 biolink:BiologicalProcess positive regulation of glycogen synthase activity, transferring glucose-1-phosphate Any process that activates or increases the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate. go.json activation of glycogen synthase activity, transferring glucose-1-phosphate|up regulation of glycogen synthase activity, transferring glucose-1-phosphate|up-regulation of glycogen synthase activity, transferring glucose-1-phosphate|upregulation of glycogen synthase activity, transferring glucose-1-phosphate http://purl.obolibrary.org/obo/GO_1904228 gocheck_do_not_annotate GO:1904227 biolink:BiologicalProcess negative regulation of glycogen synthase activity, transferring glucose-1-phosphate Any process that stops, prevents or reduces the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate. go.json down regulation of glycogen synthase activity, transferring glucose-1-phosphate|down-regulation of glycogen synthase activity, transferring glucose-1-phosphate|downregulation of glycogen synthase activity, transferring glucose-1-phosphate|inhibition of glycogen synthase activity, transferring glucose-1-phosphate http://purl.obolibrary.org/obo/GO_1904227 gocheck_do_not_annotate GO:1904226 biolink:BiologicalProcess regulation of glycogen synthase activity, transferring glucose-1-phosphate Any process that modulates the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate. go.json http://purl.obolibrary.org/obo/GO_1904226 gocheck_do_not_annotate GO:1904225 biolink:BiologicalProcess positive regulation of glucuronosyltransferase activity Any process that activates or increases the frequency, rate or extent of glucuronosyltransferase activity. go.json activation of 1-naphthol glucuronyltransferase activity|activation of 1-naphthol-UDP-glucuronosyltransferase activity|activation of 17-OH steroid UDPGT activity|activation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|activation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|activation of 3-OH androgenic UDPGT activity|activation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|activation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|activation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|activation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|activation of 4-nitrophenol UDP-glucuronyltransferase activity|activation of 4-nitrophenol UDPGT activity|activation of GT activity|activation of PNP-UDPGT|activation of UDP glucuronate-estradiol-glucuronosyltransferase activity|activation of UDP glucuronate-estriol glucuronosyltransferase activity|activation of UDP glucuronic acid transferase activity|activation of UDP glucuronosyltransferase activity|activation of UDP glucuronyltransferase activity|activation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|activation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|activation of UDP-glucuronate-bilirubin glucuronyltransferase activity|activation of UDP-glucuronosyltransferase activity|activation of UDP-glucuronyltransferase activity|activation of UDPGA transferase activity|activation of UDPGA-glucuronyltransferase activity|activation of UDPGT activity|activation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|activation of bilirubin UDP-glucuronosyltransferase activity|activation of bilirubin UDPGT activity|activation of bilirubin glucuronyltransferase activity|activation of bilirubin monoglucuronide glucuronyltransferase activity|activation of bilirubin uridine diphosphoglucuronyltransferase activity|activation of ciramadol UDP-glucuronyltransferase activity|activation of estriol UDPglucuronosyltransferase activity|activation of estrone UDPglucuronosyltransferase activity|activation of glucuronosyltransferase activity|activation of morphine glucuronyltransferase activity|activation of p-hydroxybiphenyl UDP glucuronyltransferase activity|activation of p-nitrophenol UDP-glucuronosyltransferase activity|activation of p-nitrophenol UDP-glucuronyltransferase activity|activation of p-nitrophenylglucuronosyltransferase activity|activation of p-phenylphenol glucuronyltransferase activity|activation of phenyl-UDP-glucuronosyltransferase activity|activation of pnp-UDPGT activity|activation of uridine 5'-diphosphoglucuronyltransferase activity|activation of uridine diphosphate glucuronyltransferase activity|activation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|activation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|activation of uridine diphosphoglucuronosyltransferase activity|activation of uridine diphosphoglucuronyltransferase activity|positive regulation of 1-naphthol glucuronyltransferase activity|positive regulation of 1-naphthol-UDP-glucuronosyltransferase activity|positive regulation of 17-OH steroid UDPGT activity|positive regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|positive regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|positive regulation of 3-OH androgenic UDPGT activity|positive regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|positive regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|positive regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|positive regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|positive regulation of 4-nitrophenol UDP-glucuronyltransferase activity|positive regulation of 4-nitrophenol UDPGT activity|positive regulation of GT activity|positive regulation of PNP-UDPGT|positive regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|positive regulation of UDP glucuronate-estriol glucuronosyltransferase activity|positive regulation of UDP glucuronic acid transferase activity|positive regulation of UDP glucuronosyltransferase activity|positive regulation of UDP glucuronyltransferase activity|positive regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|positive regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|positive regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|positive regulation of UDP-glucuronosyltransferase activity|positive regulation of UDP-glucuronyltransferase activity|positive regulation of UDPGA transferase activity|positive regulation of UDPGA-glucuronyltransferase activity|positive regulation of UDPGT activity|positive regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|positive regulation of bilirubin UDP-glucuronosyltransferase activity|positive regulation of bilirubin UDPGT activity|positive regulation of bilirubin glucuronyltransferase activity|positive regulation of bilirubin monoglucuronide glucuronyltransferase activity|positive regulation of bilirubin uridine diphosphoglucuronyltransferase activity|positive regulation of ciramadol UDP-glucuronyltransferase activity|positive regulation of estriol UDPglucuronosyltransferase activity|positive regulation of estrone UDPglucuronosyltransferase activity|positive regulation of morphine glucuronyltransferase activity|positive regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|positive regulation of p-nitrophenol UDP-glucuronosyltransferase activity|positive regulation of p-nitrophenol UDP-glucuronyltransferase activity|positive regulation of p-nitrophenylglucuronosyltransferase activity|positive regulation of p-phenylphenol glucuronyltransferase activity|positive regulation of phenyl-UDP-glucuronosyltransferase activity|positive regulation of pnp-UDPGT activity|positive regulation of uridine 5'-diphosphoglucuronyltransferase activity|positive regulation of uridine diphosphate glucuronyltransferase activity|positive regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronosyltransferase activity|positive regulation of uridine diphosphoglucuronyltransferase activity|up regulation of 1-naphthol glucuronyltransferase activity|up regulation of 1-naphthol-UDP-glucuronosyltransferase activity|up regulation of 17-OH steroid UDPGT activity|up regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|up regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|up regulation of 3-OH androgenic UDPGT activity|up regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|up regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|up regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|up regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|up regulation of 4-nitrophenol UDP-glucuronyltransferase activity|up regulation of 4-nitrophenol UDPGT activity|up regulation of GT activity|up regulation of PNP-UDPGT|up regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|up regulation of UDP glucuronate-estriol glucuronosyltransferase activity|up regulation of UDP glucuronic acid transferase activity|up regulation of UDP glucuronosyltransferase activity|up regulation of UDP glucuronyltransferase activity|up regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|up regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|up regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|up regulation of UDP-glucuronosyltransferase activity|up regulation of UDP-glucuronyltransferase activity|up regulation of UDPGA transferase activity|up regulation of UDPGA-glucuronyltransferase activity|up regulation of UDPGT activity|up regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|up regulation of bilirubin UDP-glucuronosyltransferase activity|up regulation of bilirubin UDPGT activity|up regulation of bilirubin glucuronyltransferase activity|up regulation of bilirubin monoglucuronide glucuronyltransferase activity|up regulation of bilirubin uridine diphosphoglucuronyltransferase activity|up regulation of ciramadol UDP-glucuronyltransferase activity|up regulation of estriol UDPglucuronosyltransferase activity|up regulation of estrone UDPglucuronosyltransferase activity|up regulation of glucuronosyltransferase activity|up regulation of morphine glucuronyltransferase activity|up regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|up regulation of p-nitrophenol UDP-glucuronosyltransferase activity|up regulation of p-nitrophenol UDP-glucuronyltransferase activity|up regulation of p-nitrophenylglucuronosyltransferase activity|up regulation of p-phenylphenol glucuronyltransferase activity|up regulation of phenyl-UDP-glucuronosyltransferase activity|up regulation of pnp-UDPGT activity|up regulation of uridine 5'-diphosphoglucuronyltransferase activity|up regulation of uridine diphosphate glucuronyltransferase activity|up regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|up regulation of uridine diphosphoglucuronosyltransferase activity|up regulation of uridine diphosphoglucuronyltransferase activity|up-regulation of 1-naphthol glucuronyltransferase activity|up-regulation of 1-naphthol-UDP-glucuronosyltransferase activity|up-regulation of 17-OH steroid UDPGT activity|up-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|up-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|up-regulation of 3-OH androgenic UDPGT activity|up-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|up-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|up-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|up-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|up-regulation of 4-nitrophenol UDP-glucuronyltransferase activity|up-regulation of 4-nitrophenol UDPGT activity|up-regulation of GT activity|up-regulation of PNP-UDPGT|up-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|up-regulation of UDP glucuronate-estriol glucuronosyltransferase activity|up-regulation of UDP glucuronic acid transferase activity|up-regulation of UDP glucuronosyltransferase activity|up-regulation of UDP glucuronyltransferase activity|up-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|up-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|up-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|up-regulation of UDP-glucuronosyltransferase activity|up-regulation of UDP-glucuronyltransferase activity|up-regulation of UDPGA transferase activity|up-regulation of UDPGA-glucuronyltransferase activity|up-regulation of UDPGT activity|up-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|up-regulation of bilirubin UDP-glucuronosyltransferase activity|up-regulation of bilirubin UDPGT activity|up-regulation of bilirubin glucuronyltransferase activity|up-regulation of bilirubin monoglucuronide glucuronyltransferase activity|up-regulation of bilirubin uridine diphosphoglucuronyltransferase activity|up-regulation of ciramadol UDP-glucuronyltransferase activity|up-regulation of estriol UDPglucuronosyltransferase activity|up-regulation of estrone UDPglucuronosyltransferase activity|up-regulation of glucuronosyltransferase activity|up-regulation of morphine glucuronyltransferase activity|up-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|up-regulation of p-nitrophenol UDP-glucuronosyltransferase activity|up-regulation of p-nitrophenol UDP-glucuronyltransferase activity|up-regulation of p-nitrophenylglucuronosyltransferase activity|up-regulation of p-phenylphenol glucuronyltransferase activity|up-regulation of phenyl-UDP-glucuronosyltransferase activity|up-regulation of pnp-UDPGT activity|up-regulation of uridine 5'-diphosphoglucuronyltransferase activity|up-regulation of uridine diphosphate glucuronyltransferase activity|up-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronosyltransferase activity|up-regulation of uridine diphosphoglucuronyltransferase activity|upregulation of 1-naphthol glucuronyltransferase activity|upregulation of 1-naphthol-UDP-glucuronosyltransferase activity|upregulation of 17-OH steroid UDPGT activity|upregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|upregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|upregulation of 3-OH androgenic UDPGT activity|upregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|upregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|upregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|upregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|upregulation of 4-nitrophenol UDP-glucuronyltransferase activity|upregulation of 4-nitrophenol UDPGT activity|upregulation of GT activity|upregulation of PNP-UDPGT|upregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|upregulation of UDP glucuronate-estriol glucuronosyltransferase activity|upregulation of UDP glucuronic acid transferase activity|upregulation of UDP glucuronosyltransferase activity|upregulation of UDP glucuronyltransferase activity|upregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|upregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|upregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|upregulation of UDP-glucuronosyltransferase activity|upregulation of UDP-glucuronyltransferase activity|upregulation of UDPGA transferase activity|upregulation of UDPGA-glucuronyltransferase activity|upregulation of UDPGT activity|upregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|upregulation of bilirubin UDP-glucuronosyltransferase activity|upregulation of bilirubin UDPGT activity|upregulation of bilirubin glucuronyltransferase activity|upregulation of bilirubin monoglucuronide glucuronyltransferase activity|upregulation of bilirubin uridine diphosphoglucuronyltransferase activity|upregulation of ciramadol UDP-glucuronyltransferase activity|upregulation of estriol UDPglucuronosyltransferase activity|upregulation of estrone UDPglucuronosyltransferase activity|upregulation of glucuronosyltransferase activity|upregulation of morphine glucuronyltransferase activity|upregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|upregulation of p-nitrophenol UDP-glucuronosyltransferase activity|upregulation of p-nitrophenol UDP-glucuronyltransferase activity|upregulation of p-nitrophenylglucuronosyltransferase activity|upregulation of p-phenylphenol glucuronyltransferase activity|upregulation of phenyl-UDP-glucuronosyltransferase activity|upregulation of pnp-UDPGT activity|upregulation of uridine 5'-diphosphoglucuronyltransferase activity|upregulation of uridine diphosphate glucuronyltransferase activity|upregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|upregulation of uridine diphosphoglucuronosyltransferase activity|upregulation of uridine diphosphoglucuronyltransferase activity http://purl.obolibrary.org/obo/GO_1904225 gocheck_do_not_annotate GO:1904224 biolink:BiologicalProcess negative regulation of glucuronosyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity. go.json down regulation of 1-naphthol glucuronyltransferase activity|down regulation of 1-naphthol-UDP-glucuronosyltransferase activity|down regulation of 17-OH steroid UDPGT activity|down regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|down regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|down regulation of 3-OH androgenic UDPGT activity|down regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|down regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|down regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|down regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|down regulation of 4-nitrophenol UDP-glucuronyltransferase activity|down regulation of 4-nitrophenol UDPGT activity|down regulation of GT activity|down regulation of PNP-UDPGT|down regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|down regulation of UDP glucuronate-estriol glucuronosyltransferase activity|down regulation of UDP glucuronic acid transferase activity|down regulation of UDP glucuronosyltransferase activity|down regulation of UDP glucuronyltransferase activity|down regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|down regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|down regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|down regulation of UDP-glucuronosyltransferase activity|down regulation of UDP-glucuronyltransferase activity|down regulation of UDPGA transferase activity|down regulation of UDPGA-glucuronyltransferase activity|down regulation of UDPGT activity|down regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|down regulation of bilirubin UDP-glucuronosyltransferase activity|down regulation of bilirubin UDPGT activity|down regulation of bilirubin glucuronyltransferase activity|down regulation of bilirubin monoglucuronide glucuronyltransferase activity|down regulation of bilirubin uridine diphosphoglucuronyltransferase activity|down regulation of ciramadol UDP-glucuronyltransferase activity|down regulation of estriol UDPglucuronosyltransferase activity|down regulation of estrone UDPglucuronosyltransferase activity|down regulation of glucuronosyltransferase activity|down regulation of morphine glucuronyltransferase activity|down regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|down regulation of p-nitrophenol UDP-glucuronosyltransferase activity|down regulation of p-nitrophenol UDP-glucuronyltransferase activity|down regulation of p-nitrophenylglucuronosyltransferase activity|down regulation of p-phenylphenol glucuronyltransferase activity|down regulation of phenyl-UDP-glucuronosyltransferase activity|down regulation of pnp-UDPGT activity|down regulation of uridine 5'-diphosphoglucuronyltransferase activity|down regulation of uridine diphosphate glucuronyltransferase activity|down regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|down regulation of uridine diphosphoglucuronosyltransferase activity|down regulation of uridine diphosphoglucuronyltransferase activity|down-regulation of 1-naphthol glucuronyltransferase activity|down-regulation of 1-naphthol-UDP-glucuronosyltransferase activity|down-regulation of 17-OH steroid UDPGT activity|down-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|down-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|down-regulation of 3-OH androgenic UDPGT activity|down-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|down-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|down-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|down-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|down-regulation of 4-nitrophenol UDP-glucuronyltransferase activity|down-regulation of 4-nitrophenol UDPGT activity|down-regulation of GT activity|down-regulation of PNP-UDPGT|down-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|down-regulation of UDP glucuronate-estriol glucuronosyltransferase activity|down-regulation of UDP glucuronic acid transferase activity|down-regulation of UDP glucuronosyltransferase activity|down-regulation of UDP glucuronyltransferase activity|down-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|down-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|down-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|down-regulation of UDP-glucuronosyltransferase activity|down-regulation of UDP-glucuronyltransferase activity|down-regulation of UDPGA transferase activity|down-regulation of UDPGA-glucuronyltransferase activity|down-regulation of UDPGT activity|down-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|down-regulation of bilirubin UDP-glucuronosyltransferase activity|down-regulation of bilirubin UDPGT activity|down-regulation of bilirubin glucuronyltransferase activity|down-regulation of bilirubin monoglucuronide glucuronyltransferase activity|down-regulation of bilirubin uridine diphosphoglucuronyltransferase activity|down-regulation of ciramadol UDP-glucuronyltransferase activity|down-regulation of estriol UDPglucuronosyltransferase activity|down-regulation of estrone UDPglucuronosyltransferase activity|down-regulation of glucuronosyltransferase activity|down-regulation of morphine glucuronyltransferase activity|down-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|down-regulation of p-nitrophenol UDP-glucuronosyltransferase activity|down-regulation of p-nitrophenol UDP-glucuronyltransferase activity|down-regulation of p-nitrophenylglucuronosyltransferase activity|down-regulation of p-phenylphenol glucuronyltransferase activity|down-regulation of phenyl-UDP-glucuronosyltransferase activity|down-regulation of pnp-UDPGT activity|down-regulation of uridine 5'-diphosphoglucuronyltransferase activity|down-regulation of uridine diphosphate glucuronyltransferase activity|down-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronosyltransferase activity|down-regulation of uridine diphosphoglucuronyltransferase activity|downregulation of 1-naphthol glucuronyltransferase activity|downregulation of 1-naphthol-UDP-glucuronosyltransferase activity|downregulation of 17-OH steroid UDPGT activity|downregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|downregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|downregulation of 3-OH androgenic UDPGT activity|downregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|downregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|downregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|downregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|downregulation of 4-nitrophenol UDP-glucuronyltransferase activity|downregulation of 4-nitrophenol UDPGT activity|downregulation of GT activity|downregulation of PNP-UDPGT|downregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|downregulation of UDP glucuronate-estriol glucuronosyltransferase activity|downregulation of UDP glucuronic acid transferase activity|downregulation of UDP glucuronosyltransferase activity|downregulation of UDP glucuronyltransferase activity|downregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|downregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|downregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|downregulation of UDP-glucuronosyltransferase activity|downregulation of UDP-glucuronyltransferase activity|downregulation of UDPGA transferase activity|downregulation of UDPGA-glucuronyltransferase activity|downregulation of UDPGT activity|downregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|downregulation of bilirubin UDP-glucuronosyltransferase activity|downregulation of bilirubin UDPGT activity|downregulation of bilirubin glucuronyltransferase activity|downregulation of bilirubin monoglucuronide glucuronyltransferase activity|downregulation of bilirubin uridine diphosphoglucuronyltransferase activity|downregulation of ciramadol UDP-glucuronyltransferase activity|downregulation of estriol UDPglucuronosyltransferase activity|downregulation of estrone UDPglucuronosyltransferase activity|downregulation of glucuronosyltransferase activity|downregulation of morphine glucuronyltransferase activity|downregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|downregulation of p-nitrophenol UDP-glucuronosyltransferase activity|downregulation of p-nitrophenol UDP-glucuronyltransferase activity|downregulation of p-nitrophenylglucuronosyltransferase activity|downregulation of p-phenylphenol glucuronyltransferase activity|downregulation of phenyl-UDP-glucuronosyltransferase activity|downregulation of pnp-UDPGT activity|downregulation of uridine 5'-diphosphoglucuronyltransferase activity|downregulation of uridine diphosphate glucuronyltransferase activity|downregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|downregulation of uridine diphosphoglucuronosyltransferase activity|downregulation of uridine diphosphoglucuronyltransferase activity|inhibition of 1-naphthol glucuronyltransferase activity|inhibition of 1-naphthol-UDP-glucuronosyltransferase activity|inhibition of 17-OH steroid UDPGT activity|inhibition of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|inhibition of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|inhibition of 3-OH androgenic UDPGT activity|inhibition of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|inhibition of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|inhibition of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|inhibition of 4-methylumbelliferone UDP-glucuronosyltransferase activity|inhibition of 4-nitrophenol UDP-glucuronyltransferase activity|inhibition of 4-nitrophenol UDPGT activity|inhibition of GT activity|inhibition of PNP-UDPGT|inhibition of UDP glucuronate-estradiol-glucuronosyltransferase activity|inhibition of UDP glucuronate-estriol glucuronosyltransferase activity|inhibition of UDP glucuronic acid transferase activity|inhibition of UDP glucuronosyltransferase activity|inhibition of UDP glucuronyltransferase activity|inhibition of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|inhibition of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|inhibition of UDP-glucuronate-bilirubin glucuronyltransferase activity|inhibition of UDP-glucuronosyltransferase activity|inhibition of UDP-glucuronyltransferase activity|inhibition of UDPGA transferase activity|inhibition of UDPGA-glucuronyltransferase activity|inhibition of UDPGT activity|inhibition of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|inhibition of bilirubin UDP-glucuronosyltransferase activity|inhibition of bilirubin UDPGT activity|inhibition of bilirubin glucuronyltransferase activity|inhibition of bilirubin monoglucuronide glucuronyltransferase activity|inhibition of bilirubin uridine diphosphoglucuronyltransferase activity|inhibition of ciramadol UDP-glucuronyltransferase activity|inhibition of estriol UDPglucuronosyltransferase activity|inhibition of estrone UDPglucuronosyltransferase activity|inhibition of glucuronosyltransferase activity|inhibition of morphine glucuronyltransferase activity|inhibition of p-hydroxybiphenyl UDP glucuronyltransferase activity|inhibition of p-nitrophenol UDP-glucuronosyltransferase activity|inhibition of p-nitrophenol UDP-glucuronyltransferase activity|inhibition of p-nitrophenylglucuronosyltransferase activity|inhibition of p-phenylphenol glucuronyltransferase activity|inhibition of phenyl-UDP-glucuronosyltransferase activity|inhibition of pnp-UDPGT activity|inhibition of uridine 5'-diphosphoglucuronyltransferase activity|inhibition of uridine diphosphate glucuronyltransferase activity|inhibition of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|inhibition of uridine diphosphoglucuronosyltransferase activity|inhibition of uridine diphosphoglucuronyltransferase activity|negative regulation of 1-naphthol glucuronyltransferase activity|negative regulation of 1-naphthol-UDP-glucuronosyltransferase activity|negative regulation of 17-OH steroid UDPGT activity|negative regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|negative regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|negative regulation of 3-OH androgenic UDPGT activity|negative regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|negative regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|negative regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|negative regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|negative regulation of 4-nitrophenol UDP-glucuronyltransferase activity|negative regulation of 4-nitrophenol UDPGT activity|negative regulation of GT activity|negative regulation of PNP-UDPGT|negative regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|negative regulation of UDP glucuronate-estriol glucuronosyltransferase activity|negative regulation of UDP glucuronic acid transferase activity|negative regulation of UDP glucuronosyltransferase activity|negative regulation of UDP glucuronyltransferase activity|negative regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|negative regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|negative regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|negative regulation of UDP-glucuronosyltransferase activity|negative regulation of UDP-glucuronyltransferase activity|negative regulation of UDPGA transferase activity|negative regulation of UDPGA-glucuronyltransferase activity|negative regulation of UDPGT activity|negative regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|negative regulation of bilirubin UDP-glucuronosyltransferase activity|negative regulation of bilirubin UDPGT activity|negative regulation of bilirubin glucuronyltransferase activity|negative regulation of bilirubin monoglucuronide glucuronyltransferase activity|negative regulation of bilirubin uridine diphosphoglucuronyltransferase activity|negative regulation of ciramadol UDP-glucuronyltransferase activity|negative regulation of estriol UDPglucuronosyltransferase activity|negative regulation of estrone UDPglucuronosyltransferase activity|negative regulation of morphine glucuronyltransferase activity|negative regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|negative regulation of p-nitrophenol UDP-glucuronosyltransferase activity|negative regulation of p-nitrophenol UDP-glucuronyltransferase activity|negative regulation of p-nitrophenylglucuronosyltransferase activity|negative regulation of p-phenylphenol glucuronyltransferase activity|negative regulation of phenyl-UDP-glucuronosyltransferase activity|negative regulation of pnp-UDPGT activity|negative regulation of uridine 5'-diphosphoglucuronyltransferase activity|negative regulation of uridine diphosphate glucuronyltransferase activity|negative regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronosyltransferase activity|negative regulation of uridine diphosphoglucuronyltransferase activity http://purl.obolibrary.org/obo/GO_1904224 gocheck_do_not_annotate GO:1904223 biolink:BiologicalProcess regulation of glucuronosyltransferase activity Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity. go.json regulation of 1-naphthol glucuronyltransferase activity|regulation of 1-naphthol-UDP-glucuronosyltransferase activity|regulation of 17-OH steroid UDPGT activity|regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity|regulation of 3-OH androgenic UDPGT activity|regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity|regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity|regulation of 4-nitrophenol UDP-glucuronyltransferase activity|regulation of 4-nitrophenol UDPGT activity|regulation of GT activity|regulation of PNP-UDPGT|regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity|regulation of UDP glucuronate-estriol glucuronosyltransferase activity|regulation of UDP glucuronic acid transferase activity|regulation of UDP glucuronosyltransferase activity|regulation of UDP glucuronyltransferase activity|regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity|regulation of UDP-glucuronosyltransferase activity|regulation of UDP-glucuronyltransferase activity|regulation of UDPGA transferase activity|regulation of UDPGA-glucuronyltransferase activity|regulation of UDPGT activity|regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|regulation of bilirubin UDP-glucuronosyltransferase activity|regulation of bilirubin UDPGT activity|regulation of bilirubin glucuronyltransferase activity|regulation of bilirubin monoglucuronide glucuronyltransferase activity|regulation of bilirubin uridine diphosphoglucuronyltransferase activity|regulation of ciramadol UDP-glucuronyltransferase activity|regulation of estriol UDPglucuronosyltransferase activity|regulation of estrone UDPglucuronosyltransferase activity|regulation of morphine glucuronyltransferase activity|regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity|regulation of p-nitrophenol UDP-glucuronosyltransferase activity|regulation of p-nitrophenol UDP-glucuronyltransferase activity|regulation of p-nitrophenylglucuronosyltransferase activity|regulation of p-phenylphenol glucuronyltransferase activity|regulation of phenyl-UDP-glucuronosyltransferase activity|regulation of pnp-UDPGT activity|regulation of uridine 5'-diphosphoglucuronyltransferase activity|regulation of uridine diphosphate glucuronyltransferase activity|regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|regulation of uridine diphosphoglucuronosyltransferase activity|regulation of uridine diphosphoglucuronyltransferase activity http://purl.obolibrary.org/obo/GO_1904223 gocheck_do_not_annotate GO:1904233 biolink:BiologicalProcess negative regulation of aconitate hydratase activity Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity. go.json down regulation of aconitase activity|down regulation of aconitate hydratase activity|down regulation of cis-aconitase activity|down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|down regulation of citrate(isocitrate) hydro-lyase activity|down-regulation of aconitase activity|down-regulation of aconitate hydratase activity|down-regulation of cis-aconitase activity|down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|down-regulation of citrate(isocitrate) hydro-lyase activity|downregulation of aconitase activity|downregulation of aconitate hydratase activity|downregulation of cis-aconitase activity|downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|downregulation of citrate(isocitrate) hydro-lyase activity|inhibition of aconitase activity|inhibition of aconitate hydratase activity|inhibition of cis-aconitase activity|inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|inhibition of citrate(isocitrate) hydro-lyase activity|negative regulation of aconitase activity|negative regulation of cis-aconitase activity|negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|negative regulation of citrate(isocitrate) hydro-lyase activity http://purl.obolibrary.org/obo/GO_1904233 gocheck_do_not_annotate GO:1904232 biolink:BiologicalProcess regulation of aconitate hydratase activity Any process that modulates the frequency, rate or extent of aconitate hydratase activity. go.json regulation of aconitase activity|regulation of cis-aconitase activity|regulation of citrate hydro-lyase activity|regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|regulation of citrate(isocitrate) hydro-lyase activity http://purl.obolibrary.org/obo/GO_1904232 gocheck_do_not_annotate GO:1904231 biolink:BiologicalProcess positive regulation of succinate dehydrogenase activity Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity. go.json activation of fumarate dehydrogenase activity|activation of fumarate reductase activity|activation of fumaric hydrogenase activity|activation of succinate dehydrogenase activity|activation of succinate oxidoreductase activity|activation of succinate:(acceptor) oxidoreductase activity|activation of succinate:acceptor oxidoreductase activity|activation of succinic acid dehydrogenase activity|activation of succinodehydrogenase activity|activation of succinyl dehydrogenase activity|positive regulation of fumarate dehydrogenase activity|positive regulation of fumarate reductase activity|positive regulation of fumaric hydrogenase activity|positive regulation of succinate oxidoreductase activity|positive regulation of succinate:(acceptor) oxidoreductase activity|positive regulation of succinate:acceptor oxidoreductase activity|positive regulation of succinic acid dehydrogenase activity|positive regulation of succinodehydrogenase activity|positive regulation of succinyl dehydrogenase activity|up regulation of fumarate dehydrogenase activity|up regulation of fumarate reductase activity|up regulation of fumaric hydrogenase activity|up regulation of succinate dehydrogenase activity|up regulation of succinate oxidoreductase activity|up regulation of succinate:(acceptor) oxidoreductase activity|up regulation of succinate:acceptor oxidoreductase activity|up regulation of succinic acid dehydrogenase activity|up regulation of succinodehydrogenase activity|up regulation of succinyl dehydrogenase activity|up-regulation of fumarate dehydrogenase activity|up-regulation of fumarate reductase activity|up-regulation of fumaric hydrogenase activity|up-regulation of succinate dehydrogenase activity|up-regulation of succinate oxidoreductase activity|up-regulation of succinate:(acceptor) oxidoreductase activity|up-regulation of succinate:acceptor oxidoreductase activity|up-regulation of succinic acid dehydrogenase activity|up-regulation of succinodehydrogenase activity|up-regulation of succinyl dehydrogenase activity|upregulation of fumarate dehydrogenase activity|upregulation of fumarate reductase activity|upregulation of fumaric hydrogenase activity|upregulation of succinate dehydrogenase activity|upregulation of succinate oxidoreductase activity|upregulation of succinate:(acceptor) oxidoreductase activity|upregulation of succinate:acceptor oxidoreductase activity|upregulation of succinic acid dehydrogenase activity|upregulation of succinodehydrogenase activity|upregulation of succinyl dehydrogenase activity http://purl.obolibrary.org/obo/GO_1904231 gocheck_do_not_annotate GO:1904230 biolink:BiologicalProcess negative regulation of succinate dehydrogenase activity Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity. go.json down regulation of fumarate dehydrogenase activity|down regulation of fumarate reductase activity|down regulation of fumaric hydrogenase activity|down regulation of succinate dehydrogenase activity|down regulation of succinate oxidoreductase activity|down regulation of succinate:(acceptor) oxidoreductase activity|down regulation of succinate:acceptor oxidoreductase activity|down regulation of succinic acid dehydrogenase activity|down regulation of succinodehydrogenase activity|down regulation of succinyl dehydrogenase activity|down-regulation of fumarate dehydrogenase activity|down-regulation of fumarate reductase activity|down-regulation of fumaric hydrogenase activity|down-regulation of succinate dehydrogenase activity|down-regulation of succinate oxidoreductase activity|down-regulation of succinate:(acceptor) oxidoreductase activity|down-regulation of succinate:acceptor oxidoreductase activity|down-regulation of succinic acid dehydrogenase activity|down-regulation of succinodehydrogenase activity|down-regulation of succinyl dehydrogenase activity|downregulation of fumarate dehydrogenase activity|downregulation of fumarate reductase activity|downregulation of fumaric hydrogenase activity|downregulation of succinate dehydrogenase activity|downregulation of succinate oxidoreductase activity|downregulation of succinate:(acceptor) oxidoreductase activity|downregulation of succinate:acceptor oxidoreductase activity|downregulation of succinic acid dehydrogenase activity|downregulation of succinodehydrogenase activity|downregulation of succinyl dehydrogenase activity|inhibition of fumarate dehydrogenase activity|inhibition of fumarate reductase activity|inhibition of fumaric hydrogenase activity|inhibition of succinate dehydrogenase activity|inhibition of succinate oxidoreductase activity|inhibition of succinate:(acceptor) oxidoreductase activity|inhibition of succinate:acceptor oxidoreductase activity|inhibition of succinic acid dehydrogenase activity|inhibition of succinodehydrogenase activity|inhibition of succinyl dehydrogenase activity|negative regulation of fumarate dehydrogenase activity|negative regulation of fumarate reductase activity|negative regulation of fumaric hydrogenase activity|negative regulation of succinate oxidoreductase activity|negative regulation of succinate:(acceptor) oxidoreductase activity|negative regulation of succinate:acceptor oxidoreductase activity|negative regulation of succinic acid dehydrogenase activity|negative regulation of succinodehydrogenase activity|negative regulation of succinyl dehydrogenase activity http://purl.obolibrary.org/obo/GO_1904230 gocheck_do_not_annotate GO:0052472 biolink:BiologicalProcess modulation by host of symbiont transcription Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription. go.json http://purl.obolibrary.org/obo/GO_0052472 GO:0052471 biolink:BiologicalProcess obsolete modulation by organism of systemic acquired resistance in symbiont OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of systemic acquired resistance in symbiont True http://purl.obolibrary.org/obo/GO_0052471 GO:0052470 biolink:BiologicalProcess obsolete modulation by host of symbiont signal transduction pathway OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052470 GO:0052476 biolink:BiologicalProcess obsolete negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway|negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway|negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway|suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052476 GO:0052475 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont cell-mediated immune response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont cell-based immune response|negative regulation by organism of symbiont cell-mediated immune response True http://purl.obolibrary.org/obo/GO_0052475 GO:0052474 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont T-cell mediated immune response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont T-cell mediated immune response True http://purl.obolibrary.org/obo/GO_0052474 GO:0052473 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont B-cell mediated immune response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont B-cell mediated immune response True http://purl.obolibrary.org/obo/GO_0052473 GO:0052489 biolink:BiologicalProcess negative regulation by host of symbiont programmed cell death Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json down regulation by host of symbiont programmed cell death|down-regulation by host of symbiont programmed cell death|downregulation by host of symbiont programmed cell death|inhibition by host of symbiont programmed cell death|inhibition of symbiont programmed cell death http://purl.obolibrary.org/obo/GO_0052489 GO:0052488 biolink:BiologicalProcess obsolete negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity OBSOLETE. This term was not defined before being made obsolete. go.json negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity|suppression of MAMP induced symbiont innate immunity|suppression of MAMP-induced symbiont innate immunity|suppression of PAMP induced symbiont innate immunity|suppression of PAMP-induced symbiont innate immunity|suppression of general elicitor induced symbiont innate immunity|suppression of general elicitor-induced symbiont innate immunity|suppression of pathogen-associated molecular pattern-induced symbiont innate immunity True http://purl.obolibrary.org/obo/GO_0052488 GO:1904239 biolink:BiologicalProcess regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Any process that modulates the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. go.json regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|regulation of p97-Ufd1-Npl4 complex assembly|regulation of p97-Ufd1-Npl4 complex formation http://purl.obolibrary.org/obo/GO_1904239 GO:1904238 biolink:BiologicalProcess pericyte cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. go.json http://purl.obolibrary.org/obo/GO_1904238 GO:1904237 biolink:BiologicalProcess positive regulation of substrate-dependent cell migration, cell attachment to substrate Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. go.json activation of substrate-bound cell migration, cell attachment to substrate|activation of substrate-dependent cell migration, cell attachment to substrate|positive regulation of substrate-bound cell migration, cell attachment to substrate|up regulation of substrate-bound cell migration, cell attachment to substrate|up regulation of substrate-dependent cell migration, cell attachment to substrate|up-regulation of substrate-bound cell migration, cell attachment to substrate|up-regulation of substrate-dependent cell migration, cell attachment to substrate|upregulation of substrate-bound cell migration, cell attachment to substrate|upregulation of substrate-dependent cell migration, cell attachment to substrate http://purl.obolibrary.org/obo/GO_1904237 GO:1904236 biolink:BiologicalProcess negative regulation of substrate-dependent cell migration, cell attachment to substrate Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. go.json down regulation of substrate-bound cell migration, cell attachment to substrate|down regulation of substrate-dependent cell migration, cell attachment to substrate|down-regulation of substrate-bound cell migration, cell attachment to substrate|down-regulation of substrate-dependent cell migration, cell attachment to substrate|downregulation of substrate-bound cell migration, cell attachment to substrate|downregulation of substrate-dependent cell migration, cell attachment to substrate|inhibition of substrate-bound cell migration, cell attachment to substrate|inhibition of substrate-dependent cell migration, cell attachment to substrate|negative regulation of substrate-bound cell migration, cell attachment to substrate http://purl.obolibrary.org/obo/GO_1904236 GO:1904235 biolink:BiologicalProcess regulation of substrate-dependent cell migration, cell attachment to substrate Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. go.json regulation of substrate-bound cell migration, cell attachment to substrate http://purl.obolibrary.org/obo/GO_1904235 GO:1904234 biolink:BiologicalProcess positive regulation of aconitate hydratase activity Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity. go.json activation of aconitase activity|activation of aconitate hydratase activity|activation of cis-aconitase activity|activation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|activation of citrate(isocitrate) hydro-lyase activity|positive regulation of aconitase activity|positive regulation of cis-aconitase activity|positive regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|positive regulation of citrate(isocitrate) hydro-lyase activity|up regulation of aconitase activity|up regulation of aconitate hydratase activity|up regulation of cis-aconitase activity|up regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|up regulation of citrate(isocitrate) hydro-lyase activity|up-regulation of aconitase activity|up-regulation of aconitate hydratase activity|up-regulation of cis-aconitase activity|up-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|up-regulation of citrate(isocitrate) hydro-lyase activity|upregulation of aconitase activity|upregulation of aconitate hydratase activity|upregulation of cis-aconitase activity|upregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|upregulation of citrate(isocitrate) hydro-lyase activity http://purl.obolibrary.org/obo/GO_1904234 gocheck_do_not_annotate GO:1904244 biolink:BiologicalProcess positive regulation of pancreatic trypsinogen secretion Any process that activates or increases the frequency, rate or extent of pancreatic trypsinogen secretion. go.json activation of pancreatic trypsinogen release|activation of pancreatic trypsinogen secretion|positive regulation of pancreatic trypsinogen release|up regulation of pancreatic trypsinogen release|up regulation of pancreatic trypsinogen secretion|up-regulation of pancreatic trypsinogen release|up-regulation of pancreatic trypsinogen secretion|upregulation of pancreatic trypsinogen release|upregulation of pancreatic trypsinogen secretion http://purl.obolibrary.org/obo/GO_1904244 GO:1904243 biolink:BiologicalProcess negative regulation of pancreatic trypsinogen secretion Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic trypsinogen secretion. go.json down regulation of pancreatic trypsinogen release|down regulation of pancreatic trypsinogen secretion|down-regulation of pancreatic trypsinogen release|down-regulation of pancreatic trypsinogen secretion|downregulation of pancreatic trypsinogen release|downregulation of pancreatic trypsinogen secretion|inhibition of pancreatic trypsinogen release|inhibition of pancreatic trypsinogen secretion|negative regulation of pancreatic trypsinogen release http://purl.obolibrary.org/obo/GO_1904243 GO:1904242 biolink:BiologicalProcess regulation of pancreatic trypsinogen secretion Any process that modulates the frequency, rate or extent of pancreatic trypsinogen secretion. go.json regulation of pancreatic trypsinogen release http://purl.obolibrary.org/obo/GO_1904242 GO:1904241 biolink:BiologicalProcess positive regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Any process that activates or increases the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. go.json activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|activation of VCP-NPL4-UFD1 AAA ATPase complex assembly|activation of VCP-NPL4-UFD1 AAA ATPase complex formation|activation of p97-Ufd1-Npl4 complex assembly|activation of p97-Ufd1-Npl4 complex formation|positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|positive regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|positive regulation of p97-Ufd1-Npl4 complex assembly|positive regulation of p97-Ufd1-Npl4 complex formation|up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|up regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|up regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|up regulation of p97-Ufd1-Npl4 complex assembly|up regulation of p97-Ufd1-Npl4 complex formation|up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|up-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|up-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|up-regulation of p97-Ufd1-Npl4 complex assembly|up-regulation of p97-Ufd1-Npl4 complex formation|upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|upregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|upregulation of VCP-NPL4-UFD1 AAA ATPase complex formation|upregulation of p97-Ufd1-Npl4 complex assembly|upregulation of p97-Ufd1-Npl4 complex formation http://purl.obolibrary.org/obo/GO_1904241 GO:1904240 biolink:BiologicalProcess negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. go.json down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|down regulation of p97-Ufd1-Npl4 complex assembly|down regulation of p97-Ufd1-Npl4 complex formation|down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|down-regulation of p97-Ufd1-Npl4 complex assembly|down-regulation of p97-Ufd1-Npl4 complex formation|downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly|downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation|downregulation of p97-Ufd1-Npl4 complex assembly|downregulation of p97-Ufd1-Npl4 complex formation|inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly|inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation|inhibition of p97-Ufd1-Npl4 complex assembly|inhibition of p97-Ufd1-Npl4 complex formation|negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly|negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation|negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation|negative regulation of p97-Ufd1-Npl4 complex assembly|negative regulation of p97-Ufd1-Npl4 complex formation http://purl.obolibrary.org/obo/GO_1904240 GO:0052483 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052483 GO:0052482 biolink:BiologicalProcess defense response by cell wall thickening A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism. go.json cell wall thickening during defense response http://purl.obolibrary.org/obo/GO_0052482 GO:0052481 biolink:BiologicalProcess obsolete negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway|negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway|negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway|negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052481 GO:0052480 biolink:BiologicalProcess obsolete negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway|negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052480 GO:0052487 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont jasmonic acid-mediated defense response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont jasmonic acid-mediated defense response|suppression by organism of symbiont JA-mediated defense response True http://purl.obolibrary.org/obo/GO_0052487 GO:0052486 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont innate immunity OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont innate immunity|negative regulation of symbiont innate immune response True http://purl.obolibrary.org/obo/GO_0052486 GO:0052485 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont inflammatory response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont inflammatory response True http://purl.obolibrary.org/obo/GO_0052485 GO:0052484 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont ethylene-mediated defense response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont ethylene-mediated defense response|suppression by organism of symbiont ethylene-mediated defense response True http://purl.obolibrary.org/obo/GO_0052484 GO:0052499 biolink:BiologicalProcess obsolete pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity OBSOLETE. This term was not defined before being made obsolete. go.json pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity True http://purl.obolibrary.org/obo/GO_0052499 GO:1904249 biolink:BiologicalProcess negative regulation of age-related resistance Any process that stops, prevents or reduces the extent of age-related resistance. go.json down regulation of ARR|down regulation of adult seedling resistance|down regulation of age-related resistance|down regulation of flowering-induced resistance|down regulation of mature seedling resistance|down regulation of senescence-induced resistance|down-regulation of ARR|down-regulation of adult seedling resistance|down-regulation of age-related resistance|down-regulation of flowering-induced resistance|down-regulation of mature seedling resistance|down-regulation of senescence-induced resistance|downregulation of ARR|downregulation of adult seedling resistance|downregulation of age-related resistance|downregulation of flowering-induced resistance|downregulation of mature seedling resistance|downregulation of senescence-induced resistance|inhibition of ARR|inhibition of adult seedling resistance|inhibition of age-related resistance|inhibition of flowering-induced resistance|inhibition of mature seedling resistance|inhibition of senescence-induced resistance|negative regulation of ARR|negative regulation of adult seedling resistance|negative regulation of flowering-induced resistance|negative regulation of mature seedling resistance|negative regulation of senescence-induced resistance http://purl.obolibrary.org/obo/GO_1904249 GO:1904248 biolink:BiologicalProcess regulation of age-related resistance Any process that modulates the extent of age-related resistance. go.json regulation of ARR|regulation of adult seedling resistance|regulation of developmental resistance|regulation of flowering-induced resistance|regulation of mature seedling resistance|regulation of ontogenic resistance|regulation of senescence-induced resistance http://purl.obolibrary.org/obo/GO_1904248 GO:1904247 biolink:BiologicalProcess positive regulation of polynucleotide adenylyltransferase activity Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity. go.json activation of AMP polynucleotidylexotransferase activity|activation of ATP-polynucleotide adenylyltransferase activity|activation of ATP:polynucleotide adenylyltransferase activity|activation of ATP:polynucleotidylexotransferase activity|activation of NTP polymerase activity|activation of RNA adenylating enzyme activity|activation of RNA formation factors, PF1|activation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|activation of poly(A) hydrolase activity|activation of poly(A) polymerase activity|activation of poly(A) synthetase activity|activation of poly-A polymerase activity|activation of polyadenylate nucleotidyltransferase activity|activation of polyadenylate polymerase activity|activation of polyadenylate synthetase activity|activation of polyadenylic acid polymerase activity|activation of polyadenylic polymerase activity|activation of polynucleotide adenylyltransferase activity|activation of terminal riboadenylate transferase activity|positive regulation of AMP polynucleotidylexotransferase activity|positive regulation of ATP-polynucleotide adenylyltransferase activity|positive regulation of ATP:polynucleotide adenylyltransferase activity|positive regulation of ATP:polynucleotidylexotransferase activity|positive regulation of NTP polymerase activity|positive regulation of RNA adenylating enzyme activity|positive regulation of RNA formation factors, PF1|positive regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|positive regulation of poly(A) hydrolase activity|positive regulation of poly(A) polymerase activity|positive regulation of poly(A) synthetase activity|positive regulation of poly-A polymerase activity|positive regulation of polyadenylate nucleotidyltransferase activity|positive regulation of polyadenylate polymerase activity|positive regulation of polyadenylate synthetase activity|positive regulation of polyadenylic acid polymerase activity|positive regulation of polyadenylic polymerase activity|positive regulation of terminal riboadenylate transferase activity|up regulation of AMP polynucleotidylexotransferase activity|up regulation of ATP-polynucleotide adenylyltransferase activity|up regulation of ATP:polynucleotide adenylyltransferase activity|up regulation of ATP:polynucleotidylexotransferase activity|up regulation of NTP polymerase activity|up regulation of RNA adenylating enzyme activity|up regulation of RNA formation factors, PF1|up regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|up regulation of poly(A) hydrolase activity|up regulation of poly(A) polymerase activity|up regulation of poly(A) synthetase activity|up regulation of poly-A polymerase activity|up regulation of polyadenylate nucleotidyltransferase activity|up regulation of polyadenylate polymerase activity|up regulation of polyadenylate synthetase activity|up regulation of polyadenylic acid polymerase activity|up regulation of polyadenylic polymerase activity|up regulation of polynucleotide adenylyltransferase activity|up regulation of terminal riboadenylate transferase activity|up-regulation of AMP polynucleotidylexotransferase activity|up-regulation of ATP-polynucleotide adenylyltransferase activity|up-regulation of ATP:polynucleotide adenylyltransferase activity|up-regulation of ATP:polynucleotidylexotransferase activity|up-regulation of NTP polymerase activity|up-regulation of RNA adenylating enzyme activity|up-regulation of RNA formation factors, PF1|up-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|up-regulation of poly(A) hydrolase activity|up-regulation of poly(A) polymerase activity|up-regulation of poly(A) synthetase activity|up-regulation of poly-A polymerase activity|up-regulation of polyadenylate nucleotidyltransferase activity|up-regulation of polyadenylate polymerase activity|up-regulation of polyadenylate synthetase activity|up-regulation of polyadenylic acid polymerase activity|up-regulation of polyadenylic polymerase activity|up-regulation of polynucleotide adenylyltransferase activity|up-regulation of terminal riboadenylate transferase activity|upregulation of AMP polynucleotidylexotransferase activity|upregulation of ATP-polynucleotide adenylyltransferase activity|upregulation of ATP:polynucleotide adenylyltransferase activity|upregulation of ATP:polynucleotidylexotransferase activity|upregulation of NTP polymerase activity|upregulation of RNA adenylating enzyme activity|upregulation of RNA formation factors, PF1|upregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|upregulation of poly(A) hydrolase activity|upregulation of poly(A) polymerase activity|upregulation of poly(A) synthetase activity|upregulation of poly-A polymerase activity|upregulation of polyadenylate nucleotidyltransferase activity|upregulation of polyadenylate polymerase activity|upregulation of polyadenylate synthetase activity|upregulation of polyadenylic acid polymerase activity|upregulation of polyadenylic polymerase activity|upregulation of polynucleotide adenylyltransferase activity|upregulation of terminal riboadenylate transferase activity http://purl.obolibrary.org/obo/GO_1904247 gocheck_do_not_annotate GO:1904246 biolink:BiologicalProcess negative regulation of polynucleotide adenylyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity. go.json down regulation of AMP polynucleotidylexotransferase activity|down regulation of ATP-polynucleotide adenylyltransferase activity|down regulation of ATP:polynucleotide adenylyltransferase activity|down regulation of ATP:polynucleotidylexotransferase activity|down regulation of NTP polymerase activity|down regulation of RNA adenylating enzyme activity|down regulation of RNA formation factors, PF1|down regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|down regulation of poly(A) hydrolase activity|down regulation of poly(A) polymerase activity|down regulation of poly(A) synthetase activity|down regulation of poly-A polymerase activity|down regulation of polyadenylate nucleotidyltransferase activity|down regulation of polyadenylate polymerase activity|down regulation of polyadenylate synthetase activity|down regulation of polyadenylic acid polymerase activity|down regulation of polyadenylic polymerase activity|down regulation of polynucleotide adenylyltransferase activity|down regulation of terminal riboadenylate transferase activity|down-regulation of AMP polynucleotidylexotransferase activity|down-regulation of ATP-polynucleotide adenylyltransferase activity|down-regulation of ATP:polynucleotide adenylyltransferase activity|down-regulation of ATP:polynucleotidylexotransferase activity|down-regulation of NTP polymerase activity|down-regulation of RNA adenylating enzyme activity|down-regulation of RNA formation factors, PF1|down-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|down-regulation of poly(A) hydrolase activity|down-regulation of poly(A) polymerase activity|down-regulation of poly(A) synthetase activity|down-regulation of poly-A polymerase activity|down-regulation of polyadenylate nucleotidyltransferase activity|down-regulation of polyadenylate polymerase activity|down-regulation of polyadenylate synthetase activity|down-regulation of polyadenylic acid polymerase activity|down-regulation of polyadenylic polymerase activity|down-regulation of polynucleotide adenylyltransferase activity|down-regulation of terminal riboadenylate transferase activity|downregulation of AMP polynucleotidylexotransferase activity|downregulation of ATP-polynucleotide adenylyltransferase activity|downregulation of ATP:polynucleotide adenylyltransferase activity|downregulation of ATP:polynucleotidylexotransferase activity|downregulation of NTP polymerase activity|downregulation of RNA adenylating enzyme activity|downregulation of RNA formation factors, PF1|downregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|downregulation of poly(A) hydrolase activity|downregulation of poly(A) polymerase activity|downregulation of poly(A) synthetase activity|downregulation of poly-A polymerase activity|downregulation of polyadenylate nucleotidyltransferase activity|downregulation of polyadenylate polymerase activity|downregulation of polyadenylate synthetase activity|downregulation of polyadenylic acid polymerase activity|downregulation of polyadenylic polymerase activity|downregulation of polynucleotide adenylyltransferase activity|downregulation of terminal riboadenylate transferase activity|inhibition of AMP polynucleotidylexotransferase activity|inhibition of ATP-polynucleotide adenylyltransferase activity|inhibition of ATP:polynucleotide adenylyltransferase activity|inhibition of ATP:polynucleotidylexotransferase activity|inhibition of NTP polymerase activity|inhibition of RNA adenylating enzyme activity|inhibition of RNA formation factors, PF1|inhibition of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|inhibition of poly(A) hydrolase activity|inhibition of poly(A) polymerase activity|inhibition of poly(A) synthetase activity|inhibition of poly-A polymerase activity|inhibition of polyadenylate nucleotidyltransferase activity|inhibition of polyadenylate polymerase activity|inhibition of polyadenylate synthetase activity|inhibition of polyadenylic acid polymerase activity|inhibition of polyadenylic polymerase activity|inhibition of polynucleotide adenylyltransferase activity|inhibition of terminal riboadenylate transferase activity|negative regulation of AMP polynucleotidylexotransferase activity|negative regulation of ATP-polynucleotide adenylyltransferase activity|negative regulation of ATP:polynucleotide adenylyltransferase activity|negative regulation of ATP:polynucleotidylexotransferase activity|negative regulation of NTP polymerase activity|negative regulation of RNA adenylating enzyme activity|negative regulation of RNA formation factors, PF1|negative regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|negative regulation of poly(A) hydrolase activity|negative regulation of poly(A) polymerase activity|negative regulation of poly(A) synthetase activity|negative regulation of poly-A polymerase activity|negative regulation of polyadenylate nucleotidyltransferase activity|negative regulation of polyadenylate polymerase activity|negative regulation of polyadenylate synthetase activity|negative regulation of polyadenylic acid polymerase activity|negative regulation of polyadenylic polymerase activity|negative regulation of terminal riboadenylate transferase activity http://purl.obolibrary.org/obo/GO_1904246 gocheck_do_not_annotate GO:1904245 biolink:BiologicalProcess regulation of polynucleotide adenylyltransferase activity Any process that modulates the frequency, rate or extent of polynucleotide adenylyltransferase activity. go.json regulation of AMP polynucleotidylexotransferase activity|regulation of ATP-polynucleotide adenylyltransferase activity|regulation of ATP:polynucleotide adenylyltransferase activity|regulation of ATP:polynucleotidylexotransferase activity|regulation of NTP polymerase activity|regulation of RNA adenylating enzyme activity|regulation of RNA formation factors, PF1|regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity|regulation of poly(A) hydrolase activity|regulation of poly(A) polymerase activity|regulation of poly(A) synthetase activity|regulation of poly-A polymerase activity|regulation of polyadenylate nucleotidyltransferase activity|regulation of polyadenylate polymerase activity|regulation of polyadenylate synthetase activity|regulation of polyadenylic acid polymerase activity|regulation of polyadenylic polymerase activity|regulation of terminal riboadenylate transferase activity http://purl.obolibrary.org/obo/GO_1904245 gocheck_do_not_annotate GO:1904255 biolink:BiologicalProcess negative regulation of iron ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity. go.json down regulation of iron cation channel activity|down regulation of iron channel activity|down regulation of iron-specific channel activity|down-regulation of iron cation channel activity|down-regulation of iron channel activity|down-regulation of iron-specific channel activity|downregulation of iron cation channel activity|downregulation of iron channel activity|downregulation of iron-specific channel activity|inhibition of iron cation channel activity|inhibition of iron channel activity|inhibition of iron-specific channel activity|negative regulation of iron cation channel activity|negative regulation of iron channel activity|negative regulation of iron-specific channel activity http://purl.obolibrary.org/obo/GO_1904255 gocheck_do_not_annotate GO:1904254 biolink:BiologicalProcess regulation of iron ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity. go.json regulation of iron cation channel activity|regulation of iron channel activity|regulation of iron-specific channel activity http://purl.obolibrary.org/obo/GO_1904254 gocheck_do_not_annotate GO:1904253 biolink:BiologicalProcess positive regulation of bile acid metabolic process Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. go.json activation of bile acid metabolic process|activation of bile acid metabolism|positive regulation of bile acid metabolism|up regulation of bile acid metabolic process|up regulation of bile acid metabolism|up-regulation of bile acid metabolic process|up-regulation of bile acid metabolism|upregulation of bile acid metabolic process|upregulation of bile acid metabolism http://purl.obolibrary.org/obo/GO_1904253 GO:1904252 biolink:BiologicalProcess negative regulation of bile acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. go.json down regulation of bile acid metabolic process|down regulation of bile acid metabolism|down-regulation of bile acid metabolic process|down-regulation of bile acid metabolism|downregulation of bile acid metabolic process|downregulation of bile acid metabolism|inhibition of bile acid metabolic process|inhibition of bile acid metabolism|negative regulation of bile acid metabolism http://purl.obolibrary.org/obo/GO_1904252 GO:1904251 biolink:BiologicalProcess regulation of bile acid metabolic process Any process that modulates the frequency, rate or extent of bile acid metabolic process. go.json regulation of bile acid metabolism http://purl.obolibrary.org/obo/GO_1904251 GO:0052490 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052490 GO:1904250 biolink:BiologicalProcess positive regulation of age-related resistance Any process that activates or increases the extent of age-related resistance. go.json activation of ARR|activation of adult seedling resistance|activation of age-related resistance|activation of flowering-induced resistance|activation of mature seedling resistance|activation of senescence-induced resistance|positive regulation of ARR|positive regulation of adult seedling resistance|positive regulation of flowering-induced resistance|positive regulation of mature seedling resistance|positive regulation of senescence-induced resistance|up regulation of ARR|up regulation of adult seedling resistance|up regulation of age-related resistance|up regulation of flowering-induced resistance|up regulation of mature seedling resistance|up regulation of senescence-induced resistance|up-regulation of ARR|up-regulation of adult seedling resistance|up-regulation of age-related resistance|up-regulation of flowering-induced resistance|up-regulation of mature seedling resistance|up-regulation of senescence-induced resistance|upregulation of ARR|upregulation of adult seedling resistance|upregulation of age-related resistance|upregulation of flowering-induced resistance|upregulation of mature seedling resistance|upregulation of senescence-induced resistance http://purl.obolibrary.org/obo/GO_1904250 GO:0052494 biolink:BiologicalProcess obsolete occlusion by host of symbiont vascular system OBSOLETE. The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052494 GO:0052493 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052493 GO:0052492 biolink:BiologicalProcess obsolete negative regulation by host of symbiont signal transduction pathway OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json down regulation by host of symbiont signal transduction pathway|down-regulation by host of symbiont signal transduction pathway|downregulation by host of symbiont signal transduction pathway|inhibition by host of symbiont signal transduction pathway|negative modulation by organism of symbiont signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052492 GO:0052491 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont salicylic acid-mediated defense response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont salicylic acid-mediated defense response|negative regulation of symbiont SA-mediated defense response|suppression by organism of symbiont salicylic acid-mediated defense response|suppression of symbiont SA mediated defense response True http://purl.obolibrary.org/obo/GO_0052491 GO:0052498 biolink:BiologicalProcess obsolete pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity OBSOLETE. This term was not defined before being made obsolete. go.json MAMP dependent activation of symbiont innate immunity|MAMP dependent induction of symbiont innate immunity|PAMP dependent activation of symbiont innate immunity|PAMP dependent induction of symbiont innate immunity|general elicitor-dependent activation of symbiont innate immunity|general elicitor-dependent induction of symbiont innate immunity|pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity|pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity True http://purl.obolibrary.org/obo/GO_0052498 GO:0052497 biolink:BiologicalProcess obsolete occlusion by organism of xylem in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction. go.json occlusion by organism of xylem in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052497 GO:0052496 biolink:BiologicalProcess obsolete occlusion by host of symbiont xylem OBSOLETE. The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052496 GO:0052495 biolink:BiologicalProcess obsolete occlusion by organism of vascular system in other organism involved in symbiotic interaction OBSOLETE. The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction. go.json occlusion by organism of vascular system in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052495 GO:1904259 biolink:BiologicalProcess regulation of basement membrane assembly involved in embryonic body morphogenesis Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1904259 GO:1904258 biolink:BiologicalProcess nuclear dicing body assembly The aggregation, arrangement and bonding together of a set of components to form a nuclear dicing body. go.json D body assembly|D body formation|nuclear dicing body formation http://purl.obolibrary.org/obo/GO_1904258 GO:1904257 biolink:BiologicalProcess zinc ion import into Golgi lumen The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen. go.json cytosol to Golgi apparatus zinc transport|zinc II ion import across Golgi membrane|zinc ion import across Golgi membrane|zinc ion import into Golgi apparatus|zinc ion import into Golgi membrane|zinc(2+) import across Golgi membrane http://purl.obolibrary.org/obo/GO_1904257 GO:1904256 biolink:BiologicalProcess positive regulation of iron ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity. go.json activation of iron cation channel activity|activation of iron channel activity|activation of iron-specific channel activity|positive regulation of iron cation channel activity|positive regulation of iron channel activity|positive regulation of iron transmembrane transporter activity|positive regulation of iron-specific channel activity|up regulation of iron cation channel activity|up regulation of iron channel activity|up regulation of iron-specific channel activity|up-regulation of iron cation channel activity|up-regulation of iron channel activity|up-regulation of iron-specific channel activity|upregulation of iron cation channel activity|upregulation of iron channel activity|upregulation of iron-specific channel activity http://purl.obolibrary.org/obo/GO_1904256 gocheck_do_not_annotate GO:1904266 biolink:BiologicalProcess regulation of Schwann cell chemotaxis Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_1904266 GO:1904265 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904265 GO:1904264 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904264 GO:1904263 biolink:BiologicalProcess positive regulation of TORC1 signaling Any process that activates or increases the frequency, rate or extent of TORC1 signaling. go.json activation of TORC1 signal transduction|activation of TORC1 signaling|positive regulation of TORC1 signal transduction|up regulation of TORC1 signal transduction|up regulation of TORC1 signaling|up-regulation of TORC1 signal transduction|up-regulation of TORC1 signaling|upregulation of TORC1 signal transduction|upregulation of TORC1 signaling http://purl.obolibrary.org/obo/GO_1904263 GO:1904262 biolink:BiologicalProcess negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. go.json down regulation of TORC1 signal transduction|down regulation of TORC1 signaling|down-regulation of TORC1 signal transduction|down-regulation of TORC1 signaling|downregulation of TORC1 signal transduction|downregulation of TORC1 signaling|inhibition of TORC1 signal transduction|inhibition of TORC1 signaling|negative regulation of TORC1 signal transduction http://purl.obolibrary.org/obo/GO_1904262 GO:1904261 biolink:BiologicalProcess positive regulation of basement membrane assembly involved in embryonic body morphogenesis Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. go.json activation of basement membrane assembly involved in embryonic body morphogenesis|up regulation of basement membrane assembly involved in embryonic body morphogenesis|up-regulation of basement membrane assembly involved in embryonic body morphogenesis|upregulation of basement membrane assembly involved in embryonic body morphogenesis http://purl.obolibrary.org/obo/GO_1904261 GO:1904260 biolink:BiologicalProcess negative regulation of basement membrane assembly involved in embryonic body morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. go.json down regulation of basement membrane assembly involved in embryonic body morphogenesis|down-regulation of basement membrane assembly involved in embryonic body morphogenesis|downregulation of basement membrane assembly involved in embryonic body morphogenesis|inhibition of basement membrane assembly involved in embryonic body morphogenesis http://purl.obolibrary.org/obo/GO_1904260 GO:1904269 biolink:CellularComponent cell leading edge cell cortex The cell cortex of the leading edge of a cell. go.json cell cortex of cell leading edge|cell cortex of front of cell|cell cortex of leading edge of cell|cell periphery of cell leading edge|cell periphery of front of cell|cell periphery of leading edge of cell|peripheral cytoplasm of cell leading edge|peripheral cytoplasm of front of cell|peripheral cytoplasm of leading edge of cell http://purl.obolibrary.org/obo/GO_1904269 GO:1904268 biolink:BiologicalProcess positive regulation of Schwann cell chemotaxis Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis. go.json activation of Schwann cell chemotaxis|up regulation of Schwann cell chemotaxis|up-regulation of Schwann cell chemotaxis|upregulation of Schwann cell chemotaxis http://purl.obolibrary.org/obo/GO_1904268 GO:1904267 biolink:BiologicalProcess negative regulation of Schwann cell chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis. go.json down regulation of Schwann cell chemotaxis|down-regulation of Schwann cell chemotaxis|downregulation of Schwann cell chemotaxis|inhibition of Schwann cell chemotaxis http://purl.obolibrary.org/obo/GO_1904267 GO:1904277 biolink:BiologicalProcess negative regulation of wax biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of wax biosynthetic process. go.json down regulation of wax anabolism|down regulation of wax biosynthesis|down regulation of wax biosynthetic process|down regulation of wax formation|down regulation of wax synthesis|down-regulation of wax anabolism|down-regulation of wax biosynthesis|down-regulation of wax biosynthetic process|down-regulation of wax formation|down-regulation of wax synthesis|downregulation of wax anabolism|downregulation of wax biosynthesis|downregulation of wax biosynthetic process|downregulation of wax formation|downregulation of wax synthesis|inhibition of wax anabolism|inhibition of wax biosynthesis|inhibition of wax biosynthetic process|inhibition of wax formation|inhibition of wax synthesis|negative regulation of wax anabolism|negative regulation of wax biosynthesis|negative regulation of wax formation|negative regulation of wax synthesis http://purl.obolibrary.org/obo/GO_1904277 GO:1904276 biolink:BiologicalProcess regulation of wax biosynthetic process Any process that modulates the frequency, rate or extent of wax biosynthetic process. go.json regulation of wax anabolism|regulation of wax biosynthesis|regulation of wax formation|regulation of wax synthesis http://purl.obolibrary.org/obo/GO_1904276 GO:1904275 biolink:BiologicalProcess tricellular tight junction disassembly The disaggregation of a tricellular tight junction into its constituent components. go.json http://purl.obolibrary.org/obo/GO_1904275 GO:1904274 biolink:BiologicalProcess tricellular tight junction assembly The aggregation, arrangement and bonding together of a set of components to form a tricellular tight junction. go.json tricellular tight junction formation http://purl.obolibrary.org/obo/GO_1904274 GO:1904273 biolink:BiologicalProcess L-alanine import across plasma membrane The directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_1904273 GO:1904272 biolink:BiologicalProcess L-tryptophan import across plasma membrane The directed movement of L-tryptophan from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_1904272 GO:1904271 biolink:BiologicalProcess L-proline import across plasma membrane The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol. go.json L-proline import into cell http://purl.obolibrary.org/obo/GO_1904271 GO:1904270 biolink:BiologicalProcess pyroptosome complex assembly The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex. go.json ASC pyroptosome assembly|ASC pyroptosome formation|pyroptosome complex formation http://purl.obolibrary.org/obo/GO_1904270 GO:0003436 biolink:BiologicalProcess regulation of cell adhesion involved in growth plate cartilage morphogenesis Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone. go.json http://purl.obolibrary.org/obo/GO_0003436 GO:0003435 biolink:BiologicalProcess smoothened signaling pathway involved in growth plate cartilage chondrocyte development The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time. go.json hedgehog signaling pathway involved in growth plate cartilage chondrocyte development|hh signaling pathway involved in growth plate cartilage chondrocyte development|smoothened signalling pathway involved in growth plate cartilage chondrocyte development http://purl.obolibrary.org/obo/GO_0003435 GO:0003437 biolink:BiologicalProcess regulation of cell communication involved in growth plate cartilage morphogenesis Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage. go.json http://purl.obolibrary.org/obo/GO_0003437 GO:0003432 biolink:BiologicalProcess cell growth involved in growth plate cartilage chondrocyte morphogenesis The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time. go.json http://purl.obolibrary.org/obo/GO_0003432 GO:0003431 biolink:BiologicalProcess growth plate cartilage chondrocyte development The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell. go.json http://purl.obolibrary.org/obo/GO_0003431 GO:0003434 biolink:BiologicalProcess obsolete BMP signaling pathway involved in growth plate cartilage chondrocyte development OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time. go.json BMP signalling pathway involved in growth plate cartilage chondrocyte development True http://purl.obolibrary.org/obo/GO_0003434 GO:0003433 biolink:BiologicalProcess chondrocyte development involved in endochondral bone morphogenesis The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. go.json http://purl.obolibrary.org/obo/GO_0003433 GO:0003430 biolink:BiologicalProcess growth plate cartilage chondrocyte growth The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. go.json growth plate cartilage chondrocyte hypertrophy http://purl.obolibrary.org/obo/GO_0003430 GO:0003414 biolink:BiologicalProcess chondrocyte morphogenesis involved in endochondral bone morphogenesis The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003414 GO:0003413 biolink:BiologicalProcess chondrocyte differentiation involved in endochondral bone morphogenesis The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. go.json http://purl.obolibrary.org/obo/GO_0003413 GO:0003416 biolink:BiologicalProcess endochondral bone growth The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. go.json http://purl.obolibrary.org/obo/GO_0003416 GO:0003415 biolink:BiologicalProcess chondrocyte hypertrophy The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. go.json http://purl.obolibrary.org/obo/GO_0003415 GO:0003410 biolink:BiologicalProcess anterior rotation of the optic cup A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis. go.json http://purl.obolibrary.org/obo/GO_0003410 GO:0003412 biolink:BiologicalProcess establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0003412 GO:0003411 biolink:BiologicalProcess cell motility involved in camera-type eye morphogenesis Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0003411 GO:0003418 biolink:BiologicalProcess growth plate cartilage chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage. go.json http://purl.obolibrary.org/obo/GO_0003418 GO:0003417 biolink:BiologicalProcess growth plate cartilage development The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. go.json http://purl.obolibrary.org/obo/GO_0003417 GO:0003419 biolink:BiologicalProcess growth plate cartilage chondrocyte proliferation The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0003419 GO:0003425 biolink:BiologicalProcess establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate. go.json http://purl.obolibrary.org/obo/GO_0003425 GO:0003424 biolink:BiologicalProcess establishment of cell polarity involved in growth plate cartilage chondrocyte division The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte. go.json growth plate cartilage chondrocyte polarization http://purl.obolibrary.org/obo/GO_0003424 GO:0003427 biolink:BiologicalProcess regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell. go.json regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway http://purl.obolibrary.org/obo/GO_0003427 GO:0003426 biolink:BiologicalProcess cytoskeleton polarization involved in growth plate cartilage chondrocyte division A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell. go.json http://purl.obolibrary.org/obo/GO_0003426 GO:0003421 biolink:BiologicalProcess growth plate cartilage axis specification The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth. go.json growth plate cartilage axis determination http://purl.obolibrary.org/obo/GO_0003421 GO:0003420 biolink:BiologicalProcess regulation of growth plate cartilage chondrocyte proliferation Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0003420 GO:0003423 biolink:BiologicalProcess growth plate cartilage chondrocyte division The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate. go.json http://purl.obolibrary.org/obo/GO_0003423 GO:0003422 biolink:BiologicalProcess growth plate cartilage morphogenesis The process in which the anatomical structures of growth plate cartilage are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003422 GO:0003429 biolink:BiologicalProcess growth plate cartilage chondrocyte morphogenesis The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0003429 GO:0003428 biolink:BiologicalProcess chondrocyte intercalation involved in growth plate cartilage morphogenesis The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone. go.json http://purl.obolibrary.org/obo/GO_0003428 GO:0052403 biolink:BiologicalProcess negative regulation by host of symbiont catalytic activity Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json down regulation by host of symbiont enzyme activity|down regulation by host of symbiont protein function|down-regulation by host of symbiont enzyme activity|down-regulation by host of symbiont protein function|downregulation by host of symbiont enzyme activity|downregulation by host of symbiont protein function|inhibition by host of symbiont enzyme activity|inhibition by host of symbiont protein function|inhibition of symbiont enzyme activity|inhibition of symbiont protein function|negative regulation by host of symbiont enzyme activity|negative regulation by host of symbiont molecular function http://purl.obolibrary.org/obo/GO_0052403 GO:0052402 biolink:BiologicalProcess obsolete induction by organism of symbiont resistance gene-dependent defense response OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of defense response in symbiont by specific elicitors|activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont|activation by organism of symbiont gene-for-gene resistance|activation by organism of symbiont resistance gene-dependent defense response|induction by organism of defense response in symbiont by specific elicitors|induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont|induction by organism of symbiont gene-for-gene resistance|induction by organism of symbiont resistance gene-dependent defense response True http://purl.obolibrary.org/obo/GO_0052402 GO:0052401 biolink:BiologicalProcess obsolete induction by organism of defense-related symbiont reactive oxygen species production OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related symbiont AOS production|activation by organism of defense-related symbiont ROI production|activation by organism of defense-related symbiont ROS production|activation by organism of defense-related symbiont active oxygen species production|activation by organism of defense-related symbiont metabolic burst|activation by organism of defense-related symbiont oxidative burst|activation by organism of defense-related symbiont reactive oxidative species production|activation by organism of defense-related symbiont reactive oxygen intermediate production|activation by organism of defense-related symbiont reactive oxygen species production|activation by organism of defense-related symbiont respiratory burst|induction by organism of defense-related symbiont AOS production|induction by organism of defense-related symbiont ROI production|induction by organism of defense-related symbiont ROS production|induction by organism of defense-related symbiont active oxygen species production|induction by organism of defense-related symbiont metabolic burst|induction by organism of defense-related symbiont oxidative burst|induction by organism of defense-related symbiont reactive oxygen intermediate production|induction by organism of defense-related symbiont reactive oxygen species production|induction by organism of defense-related symbiont respiratory burst True http://purl.obolibrary.org/obo/GO_0052401 GO:0052400 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052400 GO:0052407 biolink:BiologicalProcess obsolete metabolism by organism of carbohydrate in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of carbohydrate in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052407 GO:0052406 biolink:BiologicalProcess obsolete metabolism by host of symbiont carbohydrate OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052406 GO:0052405 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052405 GO:0052404 biolink:BiologicalProcess obsolete negative regulation by host of symbiont peptidase activity OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json down regulation by host of symbiont protease activity|down-regulation by host of symbiont protease activity|downregulation by host of symbiont protease activity|inhibition by host of symbiont protease activity|inhibition of symbiont protease activity|negative regulation by host of symbiont protease activity True http://purl.obolibrary.org/obo/GO_0052404 GO:0052409 biolink:BiologicalProcess obsolete metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of cell wall cellulose in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052409 GO:0052408 biolink:BiologicalProcess obsolete metabolism by host of symbiont cell wall cellulose OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052408 GO:0003403 biolink:BiologicalProcess optic vesicle formation The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. go.json http://purl.obolibrary.org/obo/GO_0003403 GO:0052414 biolink:BiologicalProcess obsolete metabolism by host of symbiont glucan OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052414 GO:0003402 biolink:BiologicalProcess planar cell polarity pathway involved in axis elongation The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation. go.json http://purl.obolibrary.org/obo/GO_0003402 GO:0052413 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052413 GO:0003405 biolink:BiologicalProcess optic vesicle elongation The developmental growth that results in the lengthening of the optic vesicle in the posterior direction. go.json http://purl.obolibrary.org/obo/GO_0003405 GO:0052412 biolink:BiologicalProcess obsolete metabolism by host of symbiont cell wall pectin OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052412 GO:0003404 biolink:BiologicalProcess optic vesicle morphogenesis The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. go.json http://purl.obolibrary.org/obo/GO_0003404 GO:0052411 biolink:BiologicalProcess obsolete metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of cell wall chitin in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052411 GO:0052418 biolink:BiologicalProcess obsolete metabolism by organism of protein in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of protein in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052418 GO:0052417 biolink:BiologicalProcess obsolete metabolism by host of symbiont protein OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052417 GO:0003401 biolink:BiologicalProcess axis elongation The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. go.json elongation of an axis http://purl.obolibrary.org/obo/GO_0003401 GO:0052416 biolink:BiologicalProcess obsolete metabolism by host of symbiont macromolecule OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052416 GO:0003400 biolink:BiologicalProcess regulation of COPII vesicle coating Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. go.json http://purl.obolibrary.org/obo/GO_0003400 GO:0052415 biolink:BiologicalProcess obsolete metabolism by organism of glucan in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of glucan in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052415 GO:0052419 biolink:BiologicalProcess obsolete metabolism by host of substance in symbiont OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052419 GO:0052410 biolink:BiologicalProcess obsolete metabolism by host of symbiont cell wall chitin OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052410 GO:0003407 biolink:BiologicalProcess neural retina development The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. go.json http://purl.obolibrary.org/obo/GO_0003407 GO:0003406 biolink:BiologicalProcess retinal pigment epithelium development The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells. go.json RPE development http://purl.obolibrary.org/obo/GO_0003406 GO:0003409 biolink:BiologicalProcess optic cup structural organization The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure. go.json optic cup structural organisation http://purl.obolibrary.org/obo/GO_0003409 GO:0003408 biolink:BiologicalProcess optic cup formation involved in camera-type eye development The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle. go.json http://purl.obolibrary.org/obo/GO_0003408 GO:0052425 biolink:BiologicalProcess obsolete modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system True http://purl.obolibrary.org/obo/GO_0052425 GO:0052424 biolink:BiologicalProcess obsolete modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system True http://purl.obolibrary.org/obo/GO_0052424 GO:0052423 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052423 GO:0052422 biolink:BiologicalProcess modulation by host of symbiont catalytic activity The process in which a host organism effects a change in the enzyme activity of its symbiont organism. go.json modulation by host of symbiont enzyme activity|modulation by host of symbiont molecular function http://purl.obolibrary.org/obo/GO_0052422 GO:0052429 biolink:BiologicalProcess obsolete modulation by organism of symbiont B-cell mediated immune response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont B-cell mediated immune response|regulation by organism of symbiont B-cell mediated immune response True http://purl.obolibrary.org/obo/GO_0052429 GO:0052428 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052428 GO:0052427 biolink:BiologicalProcess obsolete modulation by host of symbiont peptidase activity OBSOLETE. The process in which an organism effects a change in symbiont peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by host of symbiont protease activity True http://purl.obolibrary.org/obo/GO_0052427 GO:0052426 biolink:BiologicalProcess obsolete modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system True http://purl.obolibrary.org/obo/GO_0052426 GO:0052421 biolink:BiologicalProcess obsolete metabolism by organism of xylan in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction. go.json metabolism by organism of xylan in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052421 GO:0052420 biolink:BiologicalProcess obsolete metabolism by host of symbiont xylan OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052420 GO:0052436 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont CDPK pathway|modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway True http://purl.obolibrary.org/obo/GO_0052436 GO:0052435 biolink:BiologicalProcess obsolete modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism|modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism True http://purl.obolibrary.org/obo/GO_0052435 GO:0052434 biolink:BiologicalProcess obsolete modulation by organism of symbiont cell-mediated immune response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont cell-based immune response|modulation by organism of symbiont cell-mediated immune response True http://purl.obolibrary.org/obo/GO_0052434 GO:0052433 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052433 GO:0052439 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont cell wall callose deposition OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont cell wall callose deposition True http://purl.obolibrary.org/obo/GO_0052439 GO:0052438 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont callose deposition OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont callose deposition True http://purl.obolibrary.org/obo/GO_0052438 GO:0052437 biolink:BiologicalProcess obsolete modulation by organism of defense-related symbiont calcium ion flux OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of defense-related symbiont Ca2+ flux|modulation by organism of defense-related symbiont calcium ion flux True http://purl.obolibrary.org/obo/GO_0052437 GO:0052432 biolink:BiologicalProcess obsolete modulation by organism of symbiont apoptosis OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont apoptosis|modulation by organism of symbiont apoptotic programmed cell death True http://purl.obolibrary.org/obo/GO_0052432 GO:0052431 biolink:BiologicalProcess obsolete modulation by organism of symbiont T-cell mediated immune response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont T-cell mediated immune response True http://purl.obolibrary.org/obo/GO_0052431 GO:0052430 biolink:BiologicalProcess obsolete modulation by host of symbiont RNA levels OBSOLETE. The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0052430 GO:1904159 biolink:BiologicalProcess megasporocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a megasporocyte. go.json megaspore mother cell differentiation http://purl.obolibrary.org/obo/GO_1904159 GO:1904158 biolink:BiologicalProcess axonemal central apparatus assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus. go.json axonemal central apparatus formation http://purl.obolibrary.org/obo/GO_1904158 GO:1904157 biolink:BiologicalProcess DN4 thymocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-. go.json http://purl.obolibrary.org/obo/GO_1904157 GO:1904167 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904167 GO:1904166 biolink:BiologicalProcess obsolete negative regulation of cholesterol homeostasis OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol homeostasis. go.json down regulation of cholesterol homeostasis|down-regulation of cholesterol homeostasis|downregulation of cholesterol homeostasis|inhibition of cholesterol homeostasis True http://purl.obolibrary.org/obo/GO_1904166 GO:1904165 biolink:BiologicalProcess obsolete positive regulation of triglyceride homeostasis OBSOLETE. Any process that activates or increases the frequency, rate or extent of triglyceride homeostasis. go.json activation of triacylglycerol homeostasis|activation of triglyceride homeostasis|positive regulation of triacylglycerol homeostasis|up regulation of triacylglycerol homeostasis|up regulation of triglyceride homeostasis|up-regulation of triacylglycerol homeostasis|up-regulation of triglyceride homeostasis|upregulation of triacylglycerol homeostasis|upregulation of triglyceride homeostasis True http://purl.obolibrary.org/obo/GO_1904165 GO:1904164 biolink:BiologicalProcess obsolete negative regulation of triglyceride homeostasis OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride homeostasis. go.json down regulation of triacylglycerol homeostasis|down regulation of triglyceride homeostasis|down-regulation of triacylglycerol homeostasis|down-regulation of triglyceride homeostasis|downregulation of triacylglycerol homeostasis|downregulation of triglyceride homeostasis|inhibition of triacylglycerol homeostasis|inhibition of triglyceride homeostasis|negative regulation of triacylglycerol homeostasis True http://purl.obolibrary.org/obo/GO_1904164 GO:1904163 biolink:BiologicalProcess obsolete regulation of triglyceride homeostasis OBSOLETE. Any process that modulates the frequency, rate or extent of triglyceride homeostasis. go.json regulation of triacylglycerol homeostasis True http://purl.obolibrary.org/obo/GO_1904163 GO:1904162 biolink:MolecularActivity obsolete 5'-3' exodeoxyribonuclease activity involved in UV-damage excision repair OBSOLETE. Any 5'-3' exodeoxyribonuclease activity that is involved in UV-damage excision repair. go.json 5'-3' exodeoxyribonuclease activity involved in AER|5'-3' exodeoxyribonuclease activity involved in UV-damaged DNA endonuclease-dependent excision repair|5'-3' exodeoxyribonuclease activity involved in UVDE-dependent excision repair|5'-3' exodeoxyribonuclease activity involved in UVER|5'-3' exodeoxyribonuclease activity involved in alternative excision repair True http://purl.obolibrary.org/obo/GO_1904162 GO:1904161 biolink:BiologicalProcess DNA synthesis involved in UV-damage excision repair Any DNA synthesis that is involved in UV-damage excision repair. go.json DNA synthesis during UV-damage excision repair|DNA synthesis during UV-damaged DNA endonuclease-dependent excision repair|DNA synthesis during UVDE-dependent excision repair|DNA synthesis during UVER|DNA synthesis involved in AER|DNA synthesis involved in UV-damaged DNA endonuclease-dependent excision repair|DNA synthesis involved in UVDE-dependent excision repair|DNA synthesis involved in UVER|DNA synthesis involved in alternative excision repair|mitotic DNA repair synthesis involved in UV-damage excision repair|mitotic DNA repair synthesis involved in UV-damaged DNA endonuclease-dependent excision repair|mitotic DNA repair synthesis involved in UVDE-dependent excision repair|mitotic DNA repair synthesis involved in UVER http://purl.obolibrary.org/obo/GO_1904161 GO:1904160 biolink:BiologicalProcess protein localization to chloroplast starch grain A process in which a protein is transported to, or maintained in, a location within a chloroplast starch grain. go.json protein localisation in chloroplast starch grain|protein localisation to chloroplast starch grain|protein localization in chloroplast starch grain http://purl.obolibrary.org/obo/GO_1904160 GO:1904169 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904169 GO:1904168 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904168 GO:1904178 biolink:BiologicalProcess negative regulation of adipose tissue development Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. go.json down regulation of adipogenesis|down regulation of adipose tissue development|down-regulation of adipogenesis|down-regulation of adipose tissue development|downregulation of adipogenesis|downregulation of adipose tissue development|inhibition of adipogenesis|inhibition of adipose tissue development|negative regulation of adipogenesis http://purl.obolibrary.org/obo/GO_1904178 GO:1904177 biolink:BiologicalProcess regulation of adipose tissue development Any process that modulates the frequency, rate or extent of adipose tissue development. go.json regulation of adipogenesis http://purl.obolibrary.org/obo/GO_1904177 GO:1904176 biolink:CellularComponent carbon phosphorus lyase complex A protein complex which is capable of carbon phosphorus lyase activity. go.json http://purl.obolibrary.org/obo/GO_1904176 GO:1904175 biolink:BiologicalProcess obsolete positive regulation of histone demethylase activity (H3-K4 specific) OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific). go.json activation of histone demethylase activity (H3-K4 specific)|up regulation of histone demethylase activity (H3-K4 specific)|up-regulation of histone demethylase activity (H3-K4 specific)|upregulation of histone demethylase activity (H3-K4 specific) True http://purl.obolibrary.org/obo/GO_1904175 GO:1904174 biolink:BiologicalProcess obsolete negative regulation of histone demethylase activity (H3-K4 specific) OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific). go.json down regulation of histone demethylase activity (H3-K4 specific)|down-regulation of histone demethylase activity (H3-K4 specific)|downregulation of histone demethylase activity (H3-K4 specific)|inhibition of histone demethylase activity (H3-K4 specific) True http://purl.obolibrary.org/obo/GO_1904174 GO:1904173 biolink:BiologicalProcess obsolete regulation of histone demethylase activity (H3-K4 specific) OBSOLETE. Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific). go.json True http://purl.obolibrary.org/obo/GO_1904173 GO:1904172 biolink:BiologicalProcess positive regulation of bleb assembly Any process that activates or increases the frequency, rate or extent of bleb assembly. go.json activation of bleb assembly|activation of cell blebbing|positive regulation of cell blebbing|up regulation of bleb assembly|up regulation of cell blebbing|up-regulation of bleb assembly|up-regulation of cell blebbing|upregulation of bleb assembly|upregulation of cell blebbing http://purl.obolibrary.org/obo/GO_1904172 GO:1904171 biolink:BiologicalProcess negative regulation of bleb assembly Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. go.json down regulation of bleb assembly|down regulation of cell blebbing|down-regulation of bleb assembly|down-regulation of cell blebbing|downregulation of bleb assembly|downregulation of cell blebbing|inhibition of bleb assembly|inhibition of cell blebbing|negative regulation of cell blebbing http://purl.obolibrary.org/obo/GO_1904171 GO:1904170 biolink:BiologicalProcess regulation of bleb assembly Any process that modulates the frequency, rate or extent of bleb assembly. go.json regulation of cell blebbing http://purl.obolibrary.org/obo/GO_1904170 GO:1904179 biolink:BiologicalProcess positive regulation of adipose tissue development Any process that activates or increases the frequency, rate or extent of adipose tissue development. go.json activation of adipogenesis|activation of adipose tissue development|positive regulation of adipogenesis|up regulation of adipogenesis|up regulation of adipose tissue development|up-regulation of adipogenesis|up-regulation of adipose tissue development|upregulation of adipogenesis|upregulation of adipose tissue development http://purl.obolibrary.org/obo/GO_1904179 GO:1904189 biolink:BiologicalProcess positive regulation of transformation of host cell by virus Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus. go.json activation of transformation of host cell by virus|activation of viral transformation|activation of viral transformation of host cell|positive regulation of viral transformation|positive regulation of viral transformation of host cell|up regulation of transformation of host cell by virus|up regulation of viral transformation|up regulation of viral transformation of host cell|up-regulation of transformation of host cell by virus|up-regulation of viral transformation|up-regulation of viral transformation of host cell|upregulation of transformation of host cell by virus|upregulation of viral transformation|upregulation of viral transformation of host cell http://purl.obolibrary.org/obo/GO_1904189 GO:1904188 biolink:BiologicalProcess negative regulation of transformation of host cell by virus Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus. go.json down regulation of transformation of host cell by virus|down regulation of viral transformation|down regulation of viral transformation of host cell|down-regulation of transformation of host cell by virus|down-regulation of viral transformation|down-regulation of viral transformation of host cell|downregulation of transformation of host cell by virus|downregulation of viral transformation|downregulation of viral transformation of host cell|inhibition of transformation of host cell by virus|inhibition of viral transformation|inhibition of viral transformation of host cell|negative regulation of viral transformation|negative regulation of viral transformation of host cell http://purl.obolibrary.org/obo/GO_1904188 GO:1904187 biolink:BiologicalProcess regulation of transformation of host cell by virus Any process that modulates the frequency, rate or extent of transformation of host cell by virus. go.json regulation of viral transformation|regulation of viral transformation of host cell http://purl.obolibrary.org/obo/GO_1904187 GO:1904186 biolink:BiologicalProcess post-anaphase microtubule array organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array. go.json PAA organization|post-anaphase array organization|post-anaphase microtubule array organisation http://purl.obolibrary.org/obo/GO_1904186 GO:1904185 biolink:BiologicalProcess equatorial microtubule organizing center assembly The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center. go.json EMTOC assembly|EMTOC formation|equatorial microtubule organising centre assembly|equatorial microtubule organising centre formation|equatorial microtubule organizing center formation http://purl.obolibrary.org/obo/GO_1904185 GO:1904184 biolink:BiologicalProcess positive regulation of pyruvate dehydrogenase activity Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity. go.json activation of pyruvate dehydrogenase activity|activation of pyruvic acid dehydrogenase activity|activation of pyruvic dehydrogenase activity|positive regulation of pyruvic acid dehydrogenase activity|positive regulation of pyruvic dehydrogenase activity|up regulation of pyruvate dehydrogenase activity|up regulation of pyruvic acid dehydrogenase activity|up regulation of pyruvic dehydrogenase activity|up-regulation of pyruvate dehydrogenase activity|up-regulation of pyruvic acid dehydrogenase activity|up-regulation of pyruvic dehydrogenase activity|upregulation of pyruvate dehydrogenase activity|upregulation of pyruvic acid dehydrogenase activity|upregulation of pyruvic dehydrogenase activity http://purl.obolibrary.org/obo/GO_1904184 gocheck_do_not_annotate GO:1904183 biolink:BiologicalProcess negative regulation of pyruvate dehydrogenase activity Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity. go.json down regulation of pyruvate dehydrogenase activity|down regulation of pyruvic acid dehydrogenase activity|down regulation of pyruvic dehydrogenase activity|down-regulation of pyruvate dehydrogenase activity|down-regulation of pyruvic acid dehydrogenase activity|down-regulation of pyruvic dehydrogenase activity|downregulation of pyruvate dehydrogenase activity|downregulation of pyruvic acid dehydrogenase activity|downregulation of pyruvic dehydrogenase activity|inhibition of pyruvate dehydrogenase activity|inhibition of pyruvic acid dehydrogenase activity|inhibition of pyruvic dehydrogenase activity|negative regulation of pyruvic acid dehydrogenase activity|negative regulation of pyruvic dehydrogenase activity http://purl.obolibrary.org/obo/GO_1904183 gocheck_do_not_annotate GO:1904182 biolink:BiologicalProcess regulation of pyruvate dehydrogenase activity Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity. go.json regulation of pyruvic acid dehydrogenase activity|regulation of pyruvic dehydrogenase activity http://purl.obolibrary.org/obo/GO_1904182 gocheck_do_not_annotate GO:1904181 biolink:BiologicalProcess positive regulation of membrane depolarization Any process that activates or increases the frequency, rate or extent of membrane depolarization. go.json activation of membrane depolarization|up regulation of membrane depolarization|up-regulation of membrane depolarization|upregulation of membrane depolarization http://purl.obolibrary.org/obo/GO_1904181 GO:1904180 biolink:BiologicalProcess negative regulation of membrane depolarization Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization. go.json down regulation of membrane depolarization|down-regulation of membrane depolarization|downregulation of membrane depolarization|inhibition of membrane depolarization http://purl.obolibrary.org/obo/GO_1904180 GO:1904199 biolink:BiologicalProcess positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization. go.json activation of regulation of vascular smooth muscle cell membrane depolarization|positive regulation of regulation of vascular smooth muscle cell membrane depolarization|up regulation of regulation of vascular smooth muscle cell membrane depolarization|up-regulation of regulation of vascular smooth muscle cell membrane depolarization|upregulation of regulation of vascular smooth muscle cell membrane depolarization http://purl.obolibrary.org/obo/GO_1904199 GO:1904198 biolink:BiologicalProcess negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization. go.json down regulation of regulation of vascular smooth muscle cell membrane depolarization|down-regulation of regulation of vascular smooth muscle cell membrane depolarization|downregulation of regulation of vascular smooth muscle cell membrane depolarization|inhibition of regulation of vascular smooth muscle cell membrane depolarization|negative regulation of regulation of vascular smooth muscle cell membrane depolarization http://purl.obolibrary.org/obo/GO_1904198 GO:1904197 biolink:BiologicalProcess positive regulation of granulosa cell proliferation Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation. go.json activation of granulosa cell proliferation|up regulation of granulosa cell proliferation|up-regulation of granulosa cell proliferation|upregulation of granulosa cell proliferation http://purl.obolibrary.org/obo/GO_1904197 GO:1904196 biolink:BiologicalProcess negative regulation of granulosa cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation. go.json down regulation of granulosa cell proliferation|down-regulation of granulosa cell proliferation|downregulation of granulosa cell proliferation|inhibition of granulosa cell proliferation http://purl.obolibrary.org/obo/GO_1904196 GO:1904195 biolink:BiologicalProcess regulation of granulosa cell proliferation Any process that modulates the frequency, rate or extent of granulosa cell proliferation. go.json http://purl.obolibrary.org/obo/GO_1904195 GO:1904194 biolink:BiologicalProcess positive regulation of cholangiocyte apoptotic process Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. go.json activation of cholangiocyte apoptosis|activation of cholangiocyte apoptotic process|activation of epithelial cell of bile duct apoptosis|activation of epithelial cell of bile duct apoptotic process|positive regulation of cholangiocyte apoptosis|positive regulation of epithelial cell of bile duct apoptosis|positive regulation of epithelial cell of bile duct apoptotic process|up regulation of cholangiocyte apoptosis|up regulation of cholangiocyte apoptotic process|up regulation of epithelial cell of bile duct apoptosis|up regulation of epithelial cell of bile duct apoptotic process|up-regulation of cholangiocyte apoptosis|up-regulation of cholangiocyte apoptotic process|up-regulation of epithelial cell of bile duct apoptosis|up-regulation of epithelial cell of bile duct apoptotic process|upregulation of cholangiocyte apoptosis|upregulation of cholangiocyte apoptotic process|upregulation of epithelial cell of bile duct apoptosis|upregulation of epithelial cell of bile duct apoptotic process http://purl.obolibrary.org/obo/GO_1904194 GO:1904193 biolink:BiologicalProcess negative regulation of cholangiocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. go.json down regulation of cholangiocyte apoptosis|down regulation of cholangiocyte apoptotic process|down regulation of epithelial cell of bile duct apoptosis|down regulation of epithelial cell of bile duct apoptotic process|down-regulation of cholangiocyte apoptosis|down-regulation of cholangiocyte apoptotic process|down-regulation of epithelial cell of bile duct apoptosis|down-regulation of epithelial cell of bile duct apoptotic process|downregulation of cholangiocyte apoptosis|downregulation of cholangiocyte apoptotic process|downregulation of epithelial cell of bile duct apoptosis|downregulation of epithelial cell of bile duct apoptotic process|inhibition of cholangiocyte apoptosis|inhibition of cholangiocyte apoptotic process|inhibition of epithelial cell of bile duct apoptosis|inhibition of epithelial cell of bile duct apoptotic process|negative regulation of cholangiocyte apoptosis|negative regulation of epithelial cell of bile duct apoptosis|negative regulation of epithelial cell of bile duct apoptotic process http://purl.obolibrary.org/obo/GO_1904193 GO:1904192 biolink:BiologicalProcess regulation of cholangiocyte apoptotic process Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. go.json regulation of cholangiocyte apoptosis|regulation of epithelial cell of bile duct apoptosis|regulation of epithelial cell of bile duct apoptotic process http://purl.obolibrary.org/obo/GO_1904192 GO:1904191 biolink:BiologicalProcess positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division. go.json activation of cyclin-dependent protein kinase activity involved in meiotic nuclear division|positive regulation of CDK activity involved in meiotic nuclear division|positive regulation of cyclin-dependent protein kinase activity involved in meiosis|stimulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division|up regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division|up-regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division|upregulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division http://purl.obolibrary.org/obo/GO_1904191 gocheck_do_not_annotate GO:1904190 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904190 GO:0052568 biolink:BiologicalProcess obsolete response to symbiont phytoalexin production OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json response to symbiont phytoalexin production True http://purl.obolibrary.org/obo/GO_0052568 GO:0052567 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052567 GO:0052566 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052566 GO:0052565 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052565 GO:0052569 biolink:BiologicalProcess obsolete response to defense-related symbiont nitric oxide production OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json response to defense-related symbiont nitric oxide production True http://purl.obolibrary.org/obo/GO_0052569 GO:0052560 biolink:BiologicalProcess obsolete induction by organism of symbiont immune response OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction by organism of symbiont immune response True http://purl.obolibrary.org/obo/GO_0052560 GO:0052564 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052564 GO:0052563 biolink:BiologicalProcess obsolete negative regulation by organism of symbiont immune response OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json negative regulation by organism of symbiont immune response True http://purl.obolibrary.org/obo/GO_0052563 GO:0052562 biolink:BiologicalProcess suppression by symbiont of host immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json down regulation by symbiont of host immune response|down-regulation by symbiont of host immune response|downregulation by symbiont of host immune response|inhibition by symbiont of host immune response|negative regulation by organism of immune response of other organism involved in symbiotic interaction|negative regulation by symbiont of host immune response http://purl.obolibrary.org/obo/GO_0052562 GO:0052561 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052561 GO:0052579 biolink:MolecularActivity (+)-pulegone reductase, (+)-isomenthone as substrate, activity Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+. EC:1.3.1.81|MetaCyc:RXN-5164 go.json (+)-isomenthone:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052579 GO:0052578 biolink:MolecularActivity alpha-farnesene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate. MetaCyc:RXN-8574|RHEA:27421 go.json (E,E)-alpha-farnesene synthase activity http://purl.obolibrary.org/obo/GO_0052578 GO:0052577 biolink:MolecularActivity germacrene-D synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate. EC:4.2.3.22|KEGG_REACTION:R07648|MetaCyc:RXN-8562|RHEA:12016 go.json 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity http://purl.obolibrary.org/obo/GO_0052577 GO:0052576 biolink:BiologicalProcess carbohydrate storage The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. go.json http://purl.obolibrary.org/obo/GO_0052576 GO:0052571 biolink:BiologicalProcess obsolete response to symbiont immune response OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json response to symbiont immune response True http://purl.obolibrary.org/obo/GO_0052571 GO:0052570 biolink:BiologicalProcess obsolete response to defense-related symbiont reactive oxygen species production OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json response to defense-related symbiont reactive oxygen species production True http://purl.obolibrary.org/obo/GO_0052570 GO:0052575 biolink:BiologicalProcess carbohydrate localization Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. go.json carbohydrate localisation http://purl.obolibrary.org/obo/GO_0052575 GO:0052574 biolink:BiologicalProcess UDP-galactose biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate. go.json UDP-D-galactopyranose biosynthesis|UDP-D-galactopyranose biosynthetic process|UDP-D-galactose biosynthesis|UDP-D-galactose biosynthetic process|UDP-galactose biosynthesis|uridine diphosphate galactose biosynthesis|uridine diphosphate galactose biosynthetic process http://purl.obolibrary.org/obo/GO_0052574 GO:0052573 biolink:BiologicalProcess UDP-D-galactose metabolic process The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate. go.json UDP-D-galactopyranose metabolic process|UDP-D-galactopyranose metabolism|UDP-D-galactose metabolism|UDP-galactose metabolic process|UDP-galactose metabolism|uridine diphosphate galactose metabolic process|uridine diphosphate galactose metabolism http://purl.obolibrary.org/obo/GO_0052573 GO:0052572 biolink:BiologicalProcess response to host immune response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json response to immune response of other organism involved in symbiotic interaction http://purl.obolibrary.org/obo/GO_0052572 GO:0052589 biolink:MolecularActivity malate dehydrogenase (menaquinone) activity Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol. EC:1.1.5.4|MetaCyc:RXNI-3 go.json (S)-malate:(menaquinone) oxidoreductase activity|(S)-malate:menaquinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052589 GO:0052588 biolink:MolecularActivity diacetyl reductase ((S)-acetoin forming) activity Catalysis of the reaction: (S)-acetoin + NAD+ = diacetyl + H+ + NADH. EC:1.1.1.304|KEGG_REACTION:R09078|MetaCyc:RXN-11032|RHEA:27286 go.json (S)-acetoin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052588 GO:0052587 biolink:MolecularActivity diacetyl reductase ((R)-acetoin forming) activity Catalysis of the reaction: (R)-acetoin + NAD+ = diacetyl + H+ + NADH. EC:1.1.1.303|KEGG_REACTION:R02855|MetaCyc:RXN-11036|RHEA:22900 go.json (R)-acetoin dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052587 GO:1904101 biolink:BiologicalProcess response to acadesine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904101 GO:1904100 biolink:BiologicalProcess positive regulation of protein O-linked glycosylation Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation. go.json activation of protein O-linked glycosylation|activation of protein amino acid O-linked glycosylation|positive regulation of protein amino acid O-linked glycosylation|up regulation of protein O-linked glycosylation|up regulation of protein amino acid O-linked glycosylation|up-regulation of protein O-linked glycosylation|up-regulation of protein amino acid O-linked glycosylation|upregulation of protein O-linked glycosylation|upregulation of protein amino acid O-linked glycosylation http://purl.obolibrary.org/obo/GO_1904100 GO:0052582 biolink:MolecularActivity (+)-menthofuran synthase activity Catalysis of the reaction: (R)-pulegone + H+ + NADPH + O2 = (R)-menthofuran + 2 H2O + NADP+. EC:1.14.14.143|KEGG_REACTION:R08923|MetaCyc:1.14.13.104-RXN|RHEA:25658 go.json (+)-MFS activity|(+)-pulegone 9-hydroxylase activity|(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity|cytochrome P450 menthofuran synthase activity|menthofuran synthase activity http://purl.obolibrary.org/obo/GO_0052582 GO:0052581 biolink:MolecularActivity (-)-isopiperitenone reductase activity Catalysis of the reaction: (6R)-isoperitenone + H+ + NADPH = (2R,5R)-isopulegone + NADP+. EC:1.3.1.82|KEGG_REACTION:R06417|MetaCyc:RXN-5161|RHEA:25649 go.json (+)-cis-isopulegone:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052581 GO:0052580 biolink:MolecularActivity (+)-pulegone reductase, (-)-menthone as substrate, activity Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+. EC:1.3.1.81|MetaCyc:RXN-5164 go.json (-)-menthone:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052580 GO:0052586 biolink:MolecularActivity oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound. EC:1.7.5.- go.json http://purl.obolibrary.org/obo/GO_0052586 GO:0052585 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound. EC:1.4.5.- go.json http://purl.obolibrary.org/obo/GO_0052585 GO:0052584 biolink:MolecularActivity obsolete oxidoreductase activity, acting on halogen in donors, with NAD or NADP as acceptor OBSOLETE. Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.22.1.- go.json True http://purl.obolibrary.org/obo/GO_0052584 GO:0052583 biolink:MolecularActivity obsolete oxidoreductase activity, acting on halogen in donors OBSOLETE. Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. EC:1.22.-.- go.json True http://purl.obolibrary.org/obo/GO_0052583 GO:0052599 biolink:MolecularActivity methylputrescine oxidase activity Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+. EC:1.4.3.22|KEGG_REACTION:R05334|MetaCyc:RXN-8244 go.json N-methylputrescine:oxygen oxidoreductase (deaminating) activity http://purl.obolibrary.org/obo/GO_0052599 GO:0052598 biolink:MolecularActivity histamine oxidase activity Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+. EC:1.4.3.22|KEGG_REACTION:R02150|MetaCyc:RXN-9600|RHEA:25625|Reactome:R-HSA-5696131 go.json 1H-Imidazole-4-ethanamine oxidase activity|1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity|histamine:oxygen oxidoreductase (deaminating) activity http://purl.obolibrary.org/obo/GO_0052598 GO:1904109 biolink:BiologicalProcess positive regulation of cholesterol import Any process that activates or increases the frequency, rate or extent of cholesterol import. go.json activation of cholesterol import|activation of cholesterol uptake|positive regulation of cholesterol uptake|up regulation of cholesterol import|up regulation of cholesterol uptake|up-regulation of cholesterol import|up-regulation of cholesterol uptake|upregulation of cholesterol import|upregulation of cholesterol uptake http://purl.obolibrary.org/obo/GO_1904109 GO:1904108 biolink:BiologicalProcess protein localization to ciliary inversin compartment A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment. go.json protein localisation in ciliary inversin compartment|protein localisation to ciliary inversin compartment|protein localization in ciliary inversin compartment http://purl.obolibrary.org/obo/GO_1904108 GO:1904107 biolink:BiologicalProcess protein localization to microvillus membrane A process in which a protein is transported to, or maintained in, a location within a microvillus membrane. go.json protein localisation in microvillus membrane|protein localisation to microvillus membrane|protein localization in microvillus membrane http://purl.obolibrary.org/obo/GO_1904107 GO:1904106 biolink:BiologicalProcess protein localization to microvillus A process in which a protein is transported to, or maintained in, a location within a microvillus. go.json protein localisation in microvillus|protein localisation to microvillus|protein localization in microvillus http://purl.obolibrary.org/obo/GO_1904106 GO:1904105 biolink:BiologicalProcess positive regulation of convergent extension involved in gastrulation Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation. go.json activation of convergent extension involved in gastrulation|up regulation of convergent extension involved in gastrulation|up-regulation of convergent extension involved in gastrulation|upregulation of convergent extension involved in gastrulation http://purl.obolibrary.org/obo/GO_1904105 GO:1904104 biolink:BiologicalProcess negative regulation of convergent extension involved in gastrulation Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation. go.json down regulation of convergent extension involved in gastrulation|down-regulation of convergent extension involved in gastrulation|downregulation of convergent extension involved in gastrulation|inhibition of convergent extension involved in gastrulation http://purl.obolibrary.org/obo/GO_1904104 GO:1904103 biolink:BiologicalProcess regulation of convergent extension involved in gastrulation Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation. go.json http://purl.obolibrary.org/obo/GO_1904103 GO:1904102 biolink:BiologicalProcess cellular response to acadesine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904102 GO:1904112 biolink:BiologicalProcess obsolete positive regulation of plus-end directed microfilament motor activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of plus-end directed microfilament motor activity. go.json activation of barbed-end directed actin-filament motor activity|activation of plus-end directed actin filament motor activity|activation of plus-end directed actin-filament motor activity|activation of plus-end directed microfilament motor activity|positive regulation of barbed-end directed actin-filament motor activity|positive regulation of plus-end directed actin filament motor activity|positive regulation of plus-end directed actin-filament motor activity|up regulation of barbed-end directed actin-filament motor activity|up regulation of plus-end directed actin filament motor activity|up regulation of plus-end directed actin-filament motor activity|up regulation of plus-end directed microfilament motor activity|up-regulation of barbed-end directed actin-filament motor activity|up-regulation of plus-end directed actin filament motor activity|up-regulation of plus-end directed actin-filament motor activity|up-regulation of plus-end directed microfilament motor activity|upregulation of barbed-end directed actin-filament motor activity|upregulation of plus-end directed actin filament motor activity|upregulation of plus-end directed actin-filament motor activity|upregulation of plus-end directed microfilament motor activity True http://purl.obolibrary.org/obo/GO_1904112 GO:1904111 biolink:BiologicalProcess obsolete negative regulation of plus-end directed microfilament motor activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of plus-end directed microfilament motor activity. go.json down regulation of barbed-end directed actin-filament motor activity|down regulation of plus-end directed actin filament motor activity|down regulation of plus-end directed actin-filament motor activity|down regulation of plus-end directed microfilament motor activity|down-regulation of barbed-end directed actin-filament motor activity|down-regulation of plus-end directed actin filament motor activity|down-regulation of plus-end directed actin-filament motor activity|down-regulation of plus-end directed microfilament motor activity|downregulation of barbed-end directed actin-filament motor activity|downregulation of plus-end directed actin filament motor activity|downregulation of plus-end directed actin-filament motor activity|downregulation of plus-end directed microfilament motor activity|inhibition of barbed-end directed actin-filament motor activity|inhibition of plus-end directed actin filament motor activity|inhibition of plus-end directed actin-filament motor activity|inhibition of plus-end directed microfilament motor activity|negative regulation of barbed-end directed actin-filament motor activity|negative regulation of plus-end directed actin filament motor activity|negative regulation of plus-end directed actin-filament motor activity True http://purl.obolibrary.org/obo/GO_1904111 GO:1904110 biolink:BiologicalProcess obsolete regulation of plus-end directed microfilament motor activity OBSOLETE. Any process that modulates the frequency, rate or extent of plus-end directed microfilament motor activity. go.json regulation of barbed-end directed actin-filament motor activity|regulation of plus-end directed actin filament motor activity|regulation of plus-end directed actin-filament motor activity True http://purl.obolibrary.org/obo/GO_1904110 GO:0052593 biolink:MolecularActivity tryptamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+. EC:1.4.3.21|KEGG_REACTION:R02173|MetaCyc:RXN-1401|RHEA:59419 go.json http://purl.obolibrary.org/obo/GO_0052593 GO:0052592 biolink:MolecularActivity oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. EC:1.17.7.- go.json oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor http://purl.obolibrary.org/obo/GO_0052592 GO:0052591 biolink:MolecularActivity obsolete sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity OBSOLETE. Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8. go.json True http://purl.obolibrary.org/obo/GO_0052591 GO:0052590 biolink:MolecularActivity obsolete sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity OBSOLETE. Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol. go.json True http://purl.obolibrary.org/obo/GO_0052590 GO:0052597 biolink:MolecularActivity diamine oxidase activity Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. EC:1.4.3.22|MetaCyc:RXN-9599 go.json diamine:oxygen oxidoreductase (deaminating) activity http://purl.obolibrary.org/obo/GO_0052597 GO:0052596 biolink:MolecularActivity phenethylamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. EC:1.4.3.21|KEGG_REACTION:R02613|MetaCyc:RXN-10817|RHEA:25265 go.json http://purl.obolibrary.org/obo/GO_0052596 GO:0052595 biolink:MolecularActivity aliphatic amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. EC:1.4.3.21|MetaCyc:AMINEOXID-RXN|RHEA:16153 go.json aliphatic-amine oxidase activity|aliphatic-amine:oxygen oxidoreductase(deaminating) activity http://purl.obolibrary.org/obo/GO_0052595 GO:0052594 biolink:MolecularActivity aminoacetone:oxygen oxidoreductase(deaminating) activity Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+. EC:1.4.3.21|KEGG_REACTION:R02529|MetaCyc:AMACETOXID-RXN|RHEA:28186 go.json http://purl.obolibrary.org/obo/GO_0052594 GO:1904119 biolink:BiologicalProcess negative regulation of otic vesicle morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis. go.json down regulation of otic vesicle morphogenesis|down-regulation of otic vesicle morphogenesis|downregulation of otic vesicle morphogenesis|inhibition of otic vesicle morphogenesis http://purl.obolibrary.org/obo/GO_1904119 GO:1904118 biolink:BiologicalProcess regulation of otic vesicle morphogenesis Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1904118 GO:1904117 biolink:BiologicalProcess cellular response to vasopressin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904117 GO:1904116 biolink:BiologicalProcess response to vasopressin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904116 GO:1904115 biolink:CellularComponent axon cytoplasm Any cytoplasm that is part of a axon. go.json axoplasm http://purl.obolibrary.org/obo/GO_1904115 GO:1904114 biolink:BiologicalProcess positive regulation of muscle filament sliding Any process that activates or increases the frequency, rate or extent of muscle filament sliding. go.json activation of muscle filament sliding|up regulation of muscle filament sliding|up-regulation of muscle filament sliding|upregulation of muscle filament sliding http://purl.obolibrary.org/obo/GO_1904114 GO:1904113 biolink:BiologicalProcess negative regulation of muscle filament sliding Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding. go.json down regulation of muscle filament sliding|down-regulation of muscle filament sliding|downregulation of muscle filament sliding|inhibition of muscle filament sliding http://purl.obolibrary.org/obo/GO_1904113 GO:1904123 biolink:BiologicalProcess positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation. go.json activation of fatty acid beta-oxidation by serotonin receptor signaling pathway|stimulation of fatty acid beta-oxidation by serotonin receptor signaling pathway|up regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway|up-regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway|upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway http://purl.obolibrary.org/obo/GO_1904123 GO:1904122 biolink:BiologicalProcess positive regulation of fatty acid beta-oxidation by octopamine signaling pathway An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation. go.json activation of fatty acid beta-oxidation by octopamine signaling pathway|stimulation of fatty acid beta-oxidation by octopamine signaling pathway|up regulation of fatty acid beta-oxidation by octopamine signaling pathway|up-regulation of fatty acid beta-oxidation by octopamine signaling pathway|upregulation of fatty acid beta-oxidation by octopamine signaling pathway http://purl.obolibrary.org/obo/GO_1904122 GO:1904121 biolink:MolecularActivity phosphatidylethanolamine transfer activity Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. go.json intermembrane phosphatidylethanolamine transfer activity|phosphatidylethanolamine carrier activity|phosphatidylethanolamine transporter activity http://purl.obolibrary.org/obo/GO_1904121 GO:1904120 biolink:BiologicalProcess positive regulation of otic vesicle morphogenesis Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis. go.json activation of otic vesicle morphogenesis|up regulation of otic vesicle morphogenesis|up-regulation of otic vesicle morphogenesis|upregulation of otic vesicle morphogenesis http://purl.obolibrary.org/obo/GO_1904120 GO:1904129 biolink:BiologicalProcess positive regulation of convergent extension involved in somitogenesis Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis. go.json activation of convergent extension involved in somitogenesis|up regulation of convergent extension involved in somitogenesis|up-regulation of convergent extension involved in somitogenesis|upregulation of convergent extension involved in somitogenesis http://purl.obolibrary.org/obo/GO_1904129 GO:1904128 biolink:BiologicalProcess negative regulation of convergent extension involved in somitogenesis Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis. go.json down regulation of convergent extension involved in somitogenesis|down-regulation of convergent extension involved in somitogenesis|downregulation of convergent extension involved in somitogenesis|inhibition of convergent extension involved in somitogenesis http://purl.obolibrary.org/obo/GO_1904128 GO:1904127 biolink:BiologicalProcess regulation of convergent extension involved in somitogenesis Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis. go.json http://purl.obolibrary.org/obo/GO_1904127 GO:1904126 biolink:BiologicalProcess convergent extension involved in notochord morphogenesis Any convergent extension that is involved in notochord morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1904126 GO:1904125 biolink:BiologicalProcess convergent extension involved in rhombomere morphogenesis Any convergent extension that is involved in rhombomere morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1904125 GO:1904124 biolink:BiologicalProcess microglial cell migration The orderly movement of a microglial cell from one site to another. go.json http://purl.obolibrary.org/obo/GO_1904124 GO:1904134 biolink:BiologicalProcess negative regulation of convergent extension involved in rhombomere morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis. go.json down regulation of convergent extension involved in rhombomere morphogenesis|down-regulation of convergent extension involved in rhombomere morphogenesis|downregulation of convergent extension involved in rhombomere morphogenesis|inhibition of convergent extension involved in rhombomere morphogenesis http://purl.obolibrary.org/obo/GO_1904134 GO:1904133 biolink:BiologicalProcess regulation of convergent extension involved in rhombomere morphogenesis Any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1904133 GO:1904132 biolink:BiologicalProcess positive regulation of convergent extension involved in neural plate elongation Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation. go.json activation of convergent extension involved in neural plate elongation|up regulation of convergent extension involved in neural plate elongation|up-regulation of convergent extension involved in neural plate elongation|upregulation of convergent extension involved in neural plate elongation http://purl.obolibrary.org/obo/GO_1904132 GO:1904131 biolink:BiologicalProcess negative regulation of convergent extension involved in neural plate elongation Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation. go.json down regulation of convergent extension involved in neural plate elongation|down-regulation of convergent extension involved in neural plate elongation|downregulation of convergent extension involved in neural plate elongation|inhibition of convergent extension involved in neural plate elongation http://purl.obolibrary.org/obo/GO_1904131 GO:1904130 biolink:BiologicalProcess regulation of convergent extension involved in neural plate elongation Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation. go.json http://purl.obolibrary.org/obo/GO_1904130 GO:1904139 biolink:BiologicalProcess regulation of microglial cell migration Any process that modulates the frequency, rate or extent of microglial cell migration. go.json http://purl.obolibrary.org/obo/GO_1904139 GO:1904138 biolink:BiologicalProcess positive regulation of convergent extension involved in notochord morphogenesis Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis. go.json activation of convergent extension involved in notochord morphogenesis|up regulation of convergent extension involved in notochord morphogenesis|up-regulation of convergent extension involved in notochord morphogenesis|upregulation of convergent extension involved in notochord morphogenesis http://purl.obolibrary.org/obo/GO_1904138 GO:1904137 biolink:BiologicalProcess negative regulation of convergent extension involved in notochord morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis. go.json down regulation of convergent extension involved in notochord morphogenesis|down-regulation of convergent extension involved in notochord morphogenesis|downregulation of convergent extension involved in notochord morphogenesis|inhibition of convergent extension involved in notochord morphogenesis http://purl.obolibrary.org/obo/GO_1904137 GO:1904136 biolink:BiologicalProcess regulation of convergent extension involved in notochord morphogenesis Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1904136 GO:1904135 biolink:BiologicalProcess positive regulation of convergent extension involved in rhombomere morphogenesis Any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis. go.json activation of convergent extension involved in rhombomere morphogenesis|up regulation of convergent extension involved in rhombomere morphogenesis|up-regulation of convergent extension involved in rhombomere morphogenesis|upregulation of convergent extension involved in rhombomere morphogenesis http://purl.obolibrary.org/obo/GO_1904135 GO:1904145 biolink:BiologicalProcess negative regulation of meiotic cell cycle process involved in oocyte maturation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. go.json down regulation of meiotic cell cycle process involved in oocyte maturation|down-regulation of meiotic cell cycle process involved in oocyte maturation|downregulation of meiotic cell cycle process involved in oocyte maturation|inhibition of meiotic cell cycle process involved in oocyte maturation http://purl.obolibrary.org/obo/GO_1904145 GO:1904144 biolink:CellularComponent phosphatidylinositol phosphate phosphatase complex A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity. go.json prostatic acid phosphatase complex http://purl.obolibrary.org/obo/GO_1904144 GO:1904143 biolink:BiologicalProcess positive regulation of carotenoid biosynthetic process Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process. go.json activation of carotenoid anabolism|activation of carotenoid biosynthesis|activation of carotenoid biosynthetic process|activation of carotenoid formation|activation of carotenoid synthesis|positive regulation of carotenoid anabolism|positive regulation of carotenoid biosynthesis|positive regulation of carotenoid formation|positive regulation of carotenoid synthesis|up regulation of carotenoid anabolism|up regulation of carotenoid biosynthesis|up regulation of carotenoid biosynthetic process|up regulation of carotenoid formation|up regulation of carotenoid synthesis|up-regulation of carotenoid anabolism|up-regulation of carotenoid biosynthesis|up-regulation of carotenoid biosynthetic process|up-regulation of carotenoid formation|up-regulation of carotenoid synthesis|upregulation of carotenoid anabolism|upregulation of carotenoid biosynthesis|upregulation of carotenoid biosynthetic process|upregulation of carotenoid formation|upregulation of carotenoid synthesis http://purl.obolibrary.org/obo/GO_1904143 GO:1904142 biolink:BiologicalProcess negative regulation of carotenoid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process. go.json down regulation of carotenoid anabolism|down regulation of carotenoid biosynthesis|down regulation of carotenoid biosynthetic process|down regulation of carotenoid formation|down regulation of carotenoid synthesis|down-regulation of carotenoid anabolism|down-regulation of carotenoid biosynthesis|down-regulation of carotenoid biosynthetic process|down-regulation of carotenoid formation|down-regulation of carotenoid synthesis|downregulation of carotenoid anabolism|downregulation of carotenoid biosynthesis|downregulation of carotenoid biosynthetic process|downregulation of carotenoid formation|downregulation of carotenoid synthesis|inhibition of carotenoid anabolism|inhibition of carotenoid biosynthesis|inhibition of carotenoid biosynthetic process|inhibition of carotenoid formation|inhibition of carotenoid synthesis|negative regulation of carotenoid anabolism|negative regulation of carotenoid biosynthesis|negative regulation of carotenoid formation|negative regulation of carotenoid synthesis http://purl.obolibrary.org/obo/GO_1904142 GO:1904141 biolink:BiologicalProcess positive regulation of microglial cell migration Any process that activates or increases the frequency, rate or extent of microglial cell migration. go.json activation of microglial cell migration|up regulation of microglial cell migration|up-regulation of microglial cell migration|upregulation of microglial cell migration http://purl.obolibrary.org/obo/GO_1904141 GO:1904140 biolink:BiologicalProcess negative regulation of microglial cell migration Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration. go.json down regulation of microglial cell migration|down-regulation of microglial cell migration|downregulation of microglial cell migration|inhibition of microglial cell migration http://purl.obolibrary.org/obo/GO_1904140 GO:1904149 biolink:BiologicalProcess regulation of microglial cell mediated cytotoxicity Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity. go.json http://purl.obolibrary.org/obo/GO_1904149 GO:1904148 biolink:BiologicalProcess cellular response to nonylphenol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus. go.json http://purl.obolibrary.org/obo/GO_1904148 GO:1904147 biolink:BiologicalProcess response to nonylphenol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus. go.json http://purl.obolibrary.org/obo/GO_1904147 GO:1904146 biolink:BiologicalProcess positive regulation of meiotic cell cycle process involved in oocyte maturation Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. go.json activation of meiotic cell cycle process involved in oocyte maturation|up regulation of meiotic cell cycle process involved in oocyte maturation|up-regulation of meiotic cell cycle process involved in oocyte maturation|upregulation of meiotic cell cycle process involved in oocyte maturation http://purl.obolibrary.org/obo/GO_1904146 GO:1904156 biolink:BiologicalProcess DN3 thymocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+. go.json http://purl.obolibrary.org/obo/GO_1904156 GO:1904155 biolink:BiologicalProcess DN2 thymocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-. go.json http://purl.obolibrary.org/obo/GO_1904155 GO:1904154 biolink:BiologicalProcess positive regulation of retrograde protein transport, ER to cytosol Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol. go.json activation of protein dislocation from ER|activation of retrograde protein transport, ER to cytosol|activation of retrograde protein transport, endoplasmic reticulum to cytosol|positive regulation of protein dislocation from ER|positive regulation of protein retrotranslocation from ER|positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol|up regulation of protein dislocation from ER|up regulation of retrograde protein transport, ER to cytosol|up regulation of retrograde protein transport, endoplasmic reticulum to cytosol|up-regulation of protein dislocation from ER|up-regulation of protein retrotranslocation from ER|up-regulation of retrograde protein transport, ER to cytosol|up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol|upregulation of protein dislocation from ER|upregulation of retrograde protein transport, ER to cytosol|upregulation of retrograde protein transport, endoplasmic reticulum to cytosol http://purl.obolibrary.org/obo/GO_1904154 GO:1904153 biolink:BiologicalProcess negative regulation of retrograde protein transport, ER to cytosol Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol. go.json down regulation of protein dislocation from ER|down regulation of retrograde protein transport, ER to cytosol|down regulation of retrograde protein transport, endoplasmic reticulum to cytosol|down-regulation of protein dislocation from ER|down-regulation of retrograde protein transport, ER to cytosol|down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol|downregulation of protein dislocation from ER|downregulation of retrograde protein transport, ER to cytosol|downregulation of retrograde protein transport, endoplasmic reticulum to cytosol|inhibition of protein dislocation from ER|inhibition of retrograde protein transport, ER to cytosol|inhibition of retrograde protein transport, endoplasmic reticulum to cytosol|negative regulation of protein dislocation from ER|negative regulation of protein retrotranslocation from ER|negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol http://purl.obolibrary.org/obo/GO_1904153 GO:1904152 biolink:BiologicalProcess regulation of retrograde protein transport, ER to cytosol Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. go.json regulation of protein dislocation from ER|regulation of protein retrotranslocation from ER|regulation of retrograde protein transport, endoplasmic reticulum to cytosol http://purl.obolibrary.org/obo/GO_1904152 GO:1904151 biolink:BiologicalProcess positive regulation of microglial cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity. go.json activation of microglial cell mediated cytotoxicity|up regulation of microglial cell mediated cytotoxicity|up-regulation of microglial cell mediated cytotoxicity|upregulation of microglial cell mediated cytotoxicity http://purl.obolibrary.org/obo/GO_1904151 GO:1904150 biolink:BiologicalProcess negative regulation of microglial cell mediated cytotoxicity Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity. go.json down regulation of microglial cell mediated cytotoxicity|down-regulation of microglial cell mediated cytotoxicity|downregulation of microglial cell mediated cytotoxicity|inhibition of microglial cell mediated cytotoxicity http://purl.obolibrary.org/obo/GO_1904150 GO:0052502 biolink:BiologicalProcess obsolete positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway|activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway|induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway|stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway|up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway|up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway|upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway|upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052502 GO:0052501 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052501 GO:0052500 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont apoptosis OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of symbiont apoptosis|positive regulation by organism of symbiont apoptotic programmed cell death True http://purl.obolibrary.org/obo/GO_0052500 GO:0052506 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway|induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway|upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052506 GO:0052505 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont cell wall callose deposition OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction by organism of defense-related symbiont cell wall callose deposition|positive regulation by organism of defense-related symbiont cell wall callose deposition True http://purl.obolibrary.org/obo/GO_0052505 GO:0052504 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont callose deposition OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction by organism of defense-related papilla formation in symbiont|induction by organism of defense-related symbiont callose deposition|positive regulation by organism of defense-related papilla formation in symbiont|positive regulation by organism of defense-related symbiont callose deposition True http://purl.obolibrary.org/obo/GO_0052504 GO:0052503 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway|positive regulation of defense-related symbiont CDPK pathway by organism True http://purl.obolibrary.org/obo/GO_0052503 GO:0052509 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052509 GO:0052508 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related symbiont SA-mediated signal transduction pathway|activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway|induction by organism of defense-related symbiont SA-mediated signal transduction pathway|induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway|upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway|upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052508 GO:0052507 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of defense-related symbiont SA-mediated signal transduction pathway|activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway|induction by organism of defense-related symbiont SA-mediated signal transduction pathway|induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway|positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway|upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway|upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052507 GO:0052513 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052513 GO:0052512 biolink:BiologicalProcess obsolete positive regulation by organism of hormone or growth regulator levels in symbiont OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive modulation of hormone or growth regulator levels in symbiont|positive regulation by organism of hormone or growth regulator levels in symbiont True http://purl.obolibrary.org/obo/GO_0052512 GO:0052511 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont ethylene-mediated defense response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by organism of symbiont ethylene-mediated defense response|induction by organism of symbiont ethylene-mediated defense response|positive regulation by organism of symbiont ethylene-mediated defense response|upregulation by organism of symbiont ethylene-mediated defense response True http://purl.obolibrary.org/obo/GO_0052511 GO:0052510 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052510 GO:0052517 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont non-apoptotic programmed cell death OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of symbiont non-apoptotic programmed cell death True http://purl.obolibrary.org/obo/GO_0052517 GO:0052516 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont jasmonic acid-mediated defense response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction by organism of symbiont JA-mediated defense response|induction by organism of symbiont jasmonic acid-mediated defense response|positive regulation by organism of symbiont JA-mediated defense response|positive regulation by organism of symbiont jasmonic acid-mediated defense response True http://purl.obolibrary.org/obo/GO_0052516 GO:0052515 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont innate immunity OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of symbiont innate immunity|positive regulation of symbiont innate immune response True http://purl.obolibrary.org/obo/GO_0052515 GO:0052514 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont inflammatory response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of symbiont inflammatory response True http://purl.obolibrary.org/obo/GO_0052514 GO:0052519 biolink:BiologicalProcess positive regulation of nutrient release by symbiont Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of nutrient release from symbiont|positive regulation by host of nutrient release from symbiont|promotion of nutrient release from symbiont|stimulation by host of nutrient release from symbiont|up regulation by host of nutrient release from symbiont|up-regulation by host of nutrient release from symbiont|upregulation by host of nutrient release from symbiont http://purl.obolibrary.org/obo/GO_0052519 GO:0052518 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052518 GO:0052524 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont salicylic acid-mediated defense response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json induction by organism of symbiont SA-mediated defense response|induction by organism of symbiont salicylic acid-mediated defense response|positive regulation by organism of symbiont SA-mediated defense response|positive regulation by organism of symbiont salicylic acid-mediated defense response True http://purl.obolibrary.org/obo/GO_0052524 GO:0052523 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont programmed cell death OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json enhancement or induction of symbiont programmed cell death|positive regulation by organism of symbiont programmed cell death True http://purl.obolibrary.org/obo/GO_0052523 GO:0052522 biolink:BiologicalProcess obsolete positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction. go.json activation by organism of phagocytosis in other organism during symbiotic interaction|positive regulation by organism of phagocytosis in other organism during symbiotic interaction|stimulation by organism of phagocytosis in other organism during symbiotic interaction|up regulation by organism of phagocytosis in other organism during symbiotic interaction|up-regulation by organism of phagocytosis in other organism during symbiotic interaction|upregulation by organism of phagocytosis in other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052522 GO:0052521 biolink:BiologicalProcess obsolete positive regulation by host of symbiont phagocytosis OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of symbiont phagocytosis|stimulation by host of symbiont phagocytosis|up regulation by host of symbiont phagocytosis|up-regulation by host of symbiont phagocytosis|upregulation by host of symbiont phagocytosis True http://purl.obolibrary.org/obo/GO_0052521 GO:0052528 biolink:BiologicalProcess obsolete upregulation by organism of symbiont programmed cell death OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json enhancement of symbiont programmed cell death by organism|upregulation by organism of symbiont programmed cell death True http://purl.obolibrary.org/obo/GO_0052528 GO:0052527 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052527 GO:0052526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052526 GO:0052525 biolink:BiologicalProcess obsolete positive regulation by host of symbiont signal transduction pathway OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json activation by host of symbiont signal transduction pathway|stimulation by host of symbiont signal transduction pathway|up regulation by host of symbiont signal transduction pathway|up-regulation by host of symbiont signal transduction pathway|upregulation by host of symbiont signal transduction pathway True http://purl.obolibrary.org/obo/GO_0052525 GO:0052529 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052529 GO:0052520 biolink:BiologicalProcess obsolete positive regulation by organism of nutrient release from other organism involved in symbiotic interaction OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. go.json activation by organism of nutrient release from other organism during symbiotic interaction|positive regulation by organism of nutrient release from other organism during symbiotic interaction|promotion of nutrient release from other organism|stimulation by organism of nutrient release from other organism during symbiotic interaction|up regulation by organism of nutrient release from other organism during symbiotic interaction|up-regulation by organism of nutrient release from other organism during symbiotic interaction|upregulation by organism of nutrient release from other organism during symbiotic interaction True http://purl.obolibrary.org/obo/GO_0052520 GO:0052535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052535 GO:0052534 biolink:BiologicalProcess obsolete positive regulation by organism of induced systemic resistance in symbiont OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of induced systemic resistance in symbiont True http://purl.obolibrary.org/obo/GO_0052534 GO:0052533 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052533 GO:0052532 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052532 GO:0052539 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052539 GO:0052538 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052538 GO:0052537 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052537 GO:0052536 biolink:BiologicalProcess obsolete positive regulation by organism of systemic acquired resistance in symbiont OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of systemic acquired resistance in symbiont True http://purl.obolibrary.org/obo/GO_0052536 GO:0052531 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont calcium ion flux OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of defense-related symbiont Ca2+ flux|positive regulation by organism of defense-related symbiont calcium ion flux True http://purl.obolibrary.org/obo/GO_0052531 GO:0052530 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont resistance gene-dependent defense response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of defense response in symbiont by specific elicitors|positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont|positive regulation by organism of symbiont gene-for-gene resistance|positive regulation by organism of symbiont resistance gene-dependent defense response True http://purl.obolibrary.org/obo/GO_0052530 GO:0052546 biolink:BiologicalProcess cell wall pectin metabolic process The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. go.json cell wall pectin metabolism|cellulose and pectin-containing cell wall pectin metabolic process|pectin metabolism during cell wall biogenesis|plant-type cell wall pectin metabolic process http://purl.obolibrary.org/obo/GO_0052546 GO:0052545 biolink:BiologicalProcess callose localization Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. go.json callose localisation http://purl.obolibrary.org/obo/GO_0052545 GO:0052544 biolink:BiologicalProcess defense response by callose deposition in cell wall Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. go.json callose deposition in cell wall during defense response|callose localization in cell wall during defense response|cell wall callose deposition during defense response|cell wall callose localization during defense response http://purl.obolibrary.org/obo/GO_0052544 GO:0052543 biolink:BiologicalProcess callose deposition in cell wall Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. go.json callose localization in cell wall|cell wall callose deposition|cell wall callose localization http://purl.obolibrary.org/obo/GO_0052543 GO:0052549 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052549 GO:0052548 biolink:BiologicalProcess regulation of endopeptidase activity Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. go.json protease regulator activity http://purl.obolibrary.org/obo/GO_0052548 gocheck_do_not_annotate GO:0052547 biolink:BiologicalProcess regulation of peptidase activity Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. go.json peptidase regulator activity http://purl.obolibrary.org/obo/GO_0052547 gocheck_do_not_annotate GO:0052542 biolink:BiologicalProcess defense response by callose deposition Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. go.json callose deposition during defense response|callose localization during defense response http://purl.obolibrary.org/obo/GO_0052542 GO:0052541 biolink:BiologicalProcess plant-type cell wall cellulose metabolic process The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. go.json cell wall cellulose metabolism|cellulose and pectin-containing cell wall cellulose metabolic process http://purl.obolibrary.org/obo/GO_0052541 GO:0052540 biolink:BiologicalProcess obsolete positive regulation by organism of defense-related symbiont cell wall thickening OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of defense-related symbiont cell wall thickening|positive regulation by organism of symbiont defensive cell wall thickening True http://purl.obolibrary.org/obo/GO_0052540 GO:0052557 biolink:BiologicalProcess obsolete positive regulation by organism of symbiont immune response OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json positive regulation by organism of symbiont immune response True http://purl.obolibrary.org/obo/GO_0052557 GO:0052556 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052556 GO:0052555 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052555 GO:0052554 biolink:BiologicalProcess obsolete modulation by organism of symbiont immune response OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. go.json modulation by organism of symbiont immune response True http://purl.obolibrary.org/obo/GO_0052554 GO:0052559 biolink:BiologicalProcess induction by symbiont of host immune response Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json activation by symbiont of host immune response|induction by organism of immune response of other organism involved in symbiotic interaction|positive regulation by organism of immune response of other organism involved in symbiotic interaction|positive regulation by symbiont of host immune response|stimulation by symbiont of host immune response|up regulation by symbiont of host immune response|up-regulation by symbiont of host immune response|upregulation by symbiont of host immune response http://purl.obolibrary.org/obo/GO_0052559 GO:0052558 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052558 GO:0052553 biolink:BiologicalProcess symbiont-mediated perturbation of host immune response A process in which an organism effects a change that affects the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by organism of immune response of other organism involved in symbiotic interaction|modulation by symbiont of host immune response|perturbation of host immune response http://purl.obolibrary.org/obo/GO_0052553 GO:0052552 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052552 GO:0052551 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052551 GO:0052550 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052550 GO:0062091 biolink:CellularComponent Ycf2/FtsHi complex A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma. go.json TIC complex associated chloroplast protein import motor http://purl.obolibrary.org/obo/GO_0062091 GO:0062090 biolink:BiologicalProcess positive regulation of taurine biosynthetic process Any process that activates or increases the frequency, rate or extent of taurine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0062090 GO:0062093 biolink:BiologicalProcess lysophagy The selective autophagy process in which a damaged lysosome is degraded by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0062093 GO:0062092 biolink:CellularComponent Yae1-Lto1 complex A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p. go.json http://purl.obolibrary.org/obo/GO_0062092 GO:0062095 biolink:BiologicalProcess endoplasmic reticulum-peroxisome tethering The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other. go.json http://purl.obolibrary.org/obo/GO_0062095 GO:0062094 biolink:BiologicalProcess stomach development The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. go.json http://purl.obolibrary.org/obo/GO_0062094 GO:0062097 biolink:BiologicalProcess chemosynthesis The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane. Wikipedia:Chemosynthesis go.json http://purl.obolibrary.org/obo/GO_0062097 GO:0062096 biolink:BiologicalProcess kinetochore disassembly The disaggregation of a kinetochore into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0062096 GO:0062099 biolink:BiologicalProcess negative regulation of programmed necrotic cell death Any process that decreases the frequency, rate or extent of programmed necrotic cell death. go.json http://purl.obolibrary.org/obo/GO_0062099 GO:0062098 biolink:BiologicalProcess regulation of programmed necrotic cell death Any process that modulates the frequency, rate or extent of programmed necrotic cell death. go.json http://purl.obolibrary.org/obo/GO_0062098 GO:0086059 biolink:MolecularActivity voltage-gated calcium channel activity involved SA node cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential|voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential|voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential|voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086059 GO:0086058 biolink:MolecularActivity voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086058 GO:0086057 biolink:MolecularActivity voltage-gated calcium channel activity involved in bundle of His cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086057 GO:0086056 biolink:MolecularActivity voltage-gated calcium channel activity involved in AV node cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential|voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086056 GO:0086055 biolink:BiologicalProcess Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json http://purl.obolibrary.org/obo/GO_0086055 GO:0086054 biolink:BiologicalProcess bundle of His cell to Purkinje myocyte communication by electrical coupling The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling http://purl.obolibrary.org/obo/GO_0086054 GO:0086053 biolink:BiologicalProcess AV node cell to bundle of His cell communication by electrical coupling The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json atrioventricular node cell to bundle of His cell communication by electrical coupling http://purl.obolibrary.org/obo/GO_0086053 GO:0086052 biolink:BiologicalProcess membrane repolarization during SA node cell action potential The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json membrane repolarization involved in regulation of SA node cardiac muscle cell action potential|membrane repolarization involved in regulation of SAN cardiac muscle cell action potential|membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential|membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086052 GO:0086051 biolink:BiologicalProcess membrane repolarization during Purkinje myocyte action potential The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0086051 GO:0086050 biolink:BiologicalProcess membrane repolarization during bundle of His cell action potential The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json membrane repolarization during bundle of His cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086050 GO:0062080 biolink:MolecularActivity inhibitory MHC class Ib receptor activity Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0062080 GO:0062082 biolink:MolecularActivity HLA-E specific inhibitory MHC class Ib receptor activity Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0062082 GO:0062081 biolink:MolecularActivity activating MHC class Ib receptor activity Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0062081 GO:0062084 biolink:BiologicalProcess regulation of capsule polysaccharide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. go.json http://purl.obolibrary.org/obo/GO_0062084 GO:0062083 biolink:MolecularActivity HLA-G specific inhibitory MHC class Ib receptor activity Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0062083 GO:0062086 biolink:BiologicalProcess regulation of vein smooth muscle contraction Any process that modulates the frequency, rate or extent of vein smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0062086 GO:0062085 biolink:BiologicalProcess positive regulation of capsule polysaccharide biosynthetic process Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. go.json http://purl.obolibrary.org/obo/GO_0062085 GO:0062088 biolink:BiologicalProcess negative regulation of vein smooth muscle contraction Any process that decreases the frequency, rate or extent of vein smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0062088 GO:0062087 biolink:BiologicalProcess positive regulation of vein smooth muscle contraction Any process that increases the frequency, rate or extent of vein smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_0062087 GO:0062089 biolink:BiologicalProcess regulation of taurine biosynthetic process Any process that modulates the rate, frequency or extent of taurine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0062089 GO:0086049 biolink:BiologicalProcess membrane repolarization during AV node cell action potential The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json membrane repolarization involved in regulation of AV node cardiac muscle cell action potential|membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086049 GO:0086048 biolink:BiologicalProcess membrane depolarization during bundle of His cell action potential The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json membrane depolarization during bundle of His cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086048 GO:0086047 biolink:BiologicalProcess membrane depolarization during Purkinje myocyte cell action potential The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json http://purl.obolibrary.org/obo/GO_0086047 GO:0086046 biolink:BiologicalProcess membrane depolarization during SA node cell action potential The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json membrane depolarization involved in regulation of SA node cardiac muscle cell action potential|membrane depolarization involved in regulation of SAN cardiac muscle cell action potential|membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential|membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086046 GO:0086045 biolink:BiologicalProcess membrane depolarization during AV node cell action potential The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json membrane depolarization during AV node cardiac muscle cell action potential|membrane depolarization during atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086045 GO:0086044 biolink:BiologicalProcess atrial cardiac muscle cell to AV node cell communication by electrical coupling The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json atrial cardiomyocyte to AV node cell communication by electrical coupling|atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling http://purl.obolibrary.org/obo/GO_0086044 GO:0086043 biolink:BiologicalProcess bundle of His cell action potential An action potential that occurs in a bundle of His cell. go.json bundle of His cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086043 GO:0086042 biolink:BiologicalProcess cardiac muscle cell-cardiac muscle cell adhesion The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules. go.json cardiomyocyte-cardiomyocyte adhesion http://purl.obolibrary.org/obo/GO_0086042 GO:0086041 biolink:MolecularActivity voltage-gated potassium channel activity involved in SA node cell action potential depolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated potassium channel activity involved in SAN cell action potential depolarization|voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization|voltage-gated potassium channel activity involved in sinus node cell action potential depolarization http://purl.obolibrary.org/obo/GO_0086041 GO:0086040 biolink:MolecularActivity sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential. go.json sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential http://purl.obolibrary.org/obo/GO_0086040 GO:0086079 biolink:MolecularActivity gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. go.json http://purl.obolibrary.org/obo/GO_0086079 GO:0086078 biolink:MolecularActivity gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. go.json http://purl.obolibrary.org/obo/GO_0086078 GO:0086077 biolink:MolecularActivity gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. go.json gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling http://purl.obolibrary.org/obo/GO_0086077 GO:0086076 biolink:MolecularActivity gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. go.json gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling|gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling http://purl.obolibrary.org/obo/GO_0086076 GO:0086075 biolink:MolecularActivity gap junction channel activity involved in cardiac conduction electrical coupling A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. go.json http://purl.obolibrary.org/obo/GO_0086075 GO:0086074 biolink:BiologicalProcess Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. go.json http://purl.obolibrary.org/obo/GO_0086074 GO:0086073 biolink:BiologicalProcess bundle of His cell-Purkinje myocyte adhesion involved in cell communication The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. go.json http://purl.obolibrary.org/obo/GO_0086073 GO:0086072 biolink:BiologicalProcess AV node cell-bundle of His cell adhesion involved in cell communication The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. go.json atrioventricular node cell-bundle of His cell adhesion involved in cell communication http://purl.obolibrary.org/obo/GO_0086072 GO:0086071 biolink:BiologicalProcess atrial cardiac muscle cell-AV node cell adhesion involved in cell communication The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. go.json atrial cardiomyocyte-AV node cell adhesion involved in cell communication|atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication http://purl.obolibrary.org/obo/GO_0086071 GO:0086070 biolink:BiologicalProcess SA node cell to atrial cardiac muscle cell communication The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json SA node cardiac muscle cell to atrial cardiac muscle cell communication|SA node cardiomyocyte to atrial cardiomyocyte communication|SAN cardiomyocyte to atrial cardiomyocyte communication|sinoatrial node cardiomyocyte to atrial cardiomyocyte communication|sinus node cardiomyocyte to atrial cardiomyocyte communication http://purl.obolibrary.org/obo/GO_0086070 GO:0086069 biolink:BiologicalProcess bundle of His cell to Purkinje myocyte communication The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json atrioventricular junction myocyte to bundle branch myocyte|bundle branch myocyte to Purkinje myocyte communication|bundle of His cardiac muscle cell to Purkinje myocyte communication|bundle of His myocyte to atrioventricular junction myocyte|ventricular conduction system cell to cell communication http://purl.obolibrary.org/obo/GO_0086069 GO:0086068 biolink:BiologicalProcess Purkinje myocyte to ventricular cardiac muscle cell communication The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json http://purl.obolibrary.org/obo/GO_0086068 GO:0086067 biolink:BiologicalProcess AV node cell to bundle of His cell communication The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json atrioventricular node cell to bundle of His cell communication http://purl.obolibrary.org/obo/GO_0086067 GO:0086066 biolink:BiologicalProcess atrial cardiac muscle cell to AV node cell communication The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json atrial cardiomyocyte to AV node cell communication|atrial cardiomyocyte to atrioventricular node cell communication http://purl.obolibrary.org/obo/GO_0086066 GO:0086065 biolink:BiologicalProcess cell communication involved in cardiac conduction Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. go.json http://purl.obolibrary.org/obo/GO_0086065 GO:0086064 biolink:BiologicalProcess cell communication by electrical coupling involved in cardiac conduction The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. go.json http://purl.obolibrary.org/obo/GO_0086064 GO:0086063 biolink:MolecularActivity voltage-gated sodium channel activity involved in SA node cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential|voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential|voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential|voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086063 GO:0086062 biolink:MolecularActivity voltage-gated sodium channel activity involved in Purkinje myocyte action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086062 GO:0086061 biolink:MolecularActivity voltage-gated sodium channel activity involved in bundle of His cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086061 GO:0086060 biolink:MolecularActivity voltage-gated sodium channel activity involved in AV node cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential|voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086060 GO:0086099 biolink:BiologicalProcess phospholipase C-activating angiotensin-activated signaling pathway involved in heart process An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores. go.json Gq-coupled angiotensin receptor signaling pathway involved in heart process|PLC-activating angiotensin receptor signaling pathway involved in heart process|angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process|cardiac angiotensin receptor signaling pathway via activation of PLC|phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_0086099 GO:0086098 biolink:BiologicalProcess angiotensin-activated signaling pathway involved in heart process An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart. go.json angiotensin receptor signaling pathway involved in heart process|angiotensin receptor signalling pathway involved in heart process|angiotensin-mediated signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_0086098 GO:0086097 biolink:BiologicalProcess phospholipase C-activating angiotensin-activated signaling pathway A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json Gq-coupled angiotensin receptor signaling pathway|PLC-activating angiotensin receptor signaling pathway|angiotensin-mediated signaling pathway via activation of phospholipase C|phospholipase C-activating angiotensin receptor signaling pathway|phospholipase C-activating angiotensin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0086097 GO:0086096 biolink:BiologicalProcess adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process An adenylate cyclase-inhibiting adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart. go.json G-inhibitory-coupled Beta2AR signaling pathway involved in heart process|Gi-coupled Beta2-AR signaling pathway involved in heart process|Gi-coupled adrenergic receptor signaling pathway involved in heart process|cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity http://purl.obolibrary.org/obo/GO_0086096 GO:0086095 biolink:BiologicalProcess positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate. go.json Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate|cardiac muscarinic receptor signaling via Gbeta/gamma|muscarinic receptor signaling pathway involved in activation of IKACH|muscarinic receptor signaling pathway involved in ion channel activation|positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling http://purl.obolibrary.org/obo/GO_0086095 gocheck_do_not_annotate GO:0086094 biolink:BiologicalProcess positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction. go.json adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation http://purl.obolibrary.org/obo/GO_0086094 GO:0086093 biolink:BiologicalProcess G protein-coupled acetylcholine receptor signaling pathway involved in heart process A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart. go.json G-protein coupled acetylcholine receptor signaling pathway involved in heart process|G-protein coupled acetylcholine receptor signalling pathway involved in heart process|M2 receptor signaling pathway involved in heart process|muscarinic receptor signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_0086093 GO:0086092 biolink:BiologicalProcess regulation of the force of heart contraction by cardiac conduction A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled. go.json http://purl.obolibrary.org/obo/GO_0086092 GO:0086091 biolink:BiologicalProcess regulation of heart rate by cardiac conduction A cardiac conduction process that modulates the frequency or rate of heart contraction. go.json http://purl.obolibrary.org/obo/GO_0086091 GO:0086090 biolink:MolecularActivity voltage-gated potassium channel activity involved in SA node cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated potassium channel activity involved in SAN cell action potential|voltage-gated potassium channel activity involved in sinoatrial node cell action potential|voltage-gated potassium channel activity involved in sinus node cell action potential http://purl.obolibrary.org/obo/GO_0086090 GO:0086089 biolink:MolecularActivity voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization http://purl.obolibrary.org/obo/GO_0086089 GO:0086088 biolink:MolecularActivity voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086088 GO:0086087 biolink:MolecularActivity voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086087 GO:0086086 biolink:MolecularActivity voltage-gated potassium channel activity involved in AV node cell action potential repolarization Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization|voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086086 GO:0086085 biolink:MolecularActivity cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells. go.json cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication http://purl.obolibrary.org/obo/GO_0086085 GO:0086084 biolink:MolecularActivity cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells. go.json http://purl.obolibrary.org/obo/GO_0086084 GO:0086083 biolink:MolecularActivity cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. go.json http://purl.obolibrary.org/obo/GO_0086083 GO:0086082 biolink:MolecularActivity cell adhesive protein binding involved in AV node cell-bundle of His cell communication Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells. go.json cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication http://purl.obolibrary.org/obo/GO_0086082 GO:0086081 biolink:MolecularActivity cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells. go.json cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication|cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication http://purl.obolibrary.org/obo/GO_0086081 GO:0086080 biolink:MolecularActivity protein binding involved in heterotypic cell-cell adhesion Binding to a protein or protein complex contributing to the adhesion of two different types of cells. go.json http://purl.obolibrary.org/obo/GO_0086080 GO:0052689 biolink:MolecularActivity carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond. EC:3.1.1.-|KEGG_REACTION:R00630|Reactome:R-HSA-5693691|Reactome:R-HSA-8937442|Reactome:R-HSA-9749792|UM-BBD_reactionID:r1025 go.json carboxylate esterase activity|carboxylic esterase activity|hydrolase activity acting on ester bonds http://purl.obolibrary.org/obo/GO_0052689 goslim_drosophila GO:0003711 biolink:MolecularActivity transcription elongation factor activity A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases. go.json transcription elongation regulator activity|transcriptional elongation regulator activity http://purl.obolibrary.org/obo/GO_0003711 GO:0052688 biolink:MolecularActivity (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. KEGG_REACTION:R06515 go.json 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0052688 GO:0003710 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003710 GO:0003713 biolink:MolecularActivity transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. go.json RNA polymerase II transcription co-activator activity|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription mediator activity|transcription co-activator activity http://purl.obolibrary.org/obo/GO_0003713 GO:0052687 biolink:MolecularActivity (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. KEGG_REACTION:R06396 go.json 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0052687 GO:0003712 biolink:MolecularActivity transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. go.json RNA polymerase II transcriptional cofactor activity|transcription cofactor activity|transcriptional co-regulator http://purl.obolibrary.org/obo/GO_0003712 goslim_drosophila GO:0052686 biolink:MolecularActivity perillic acid-CoA ligase (AMP-forming) activity Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA. KEGG_REACTION:R06368 go.json perillic acid:CoA ligase (AMP-forming) activity|perillyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0052686 GO:1904439 biolink:BiologicalProcess negative regulation of iron ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane. go.json down regulation of ferrous ion import into cell|down regulation of ferrous iron import across plasma membrane|down-regulation of ferrous ion import into cell|down-regulation of ferrous iron import across plasma membrane|downregulation of ferrous ion import into cell|downregulation of ferrous iron import across plasma membrane|inhibition of ferrous ion import into cell|inhibition of ferrous iron import across plasma membrane|negative regulation of ferrous ion import into cell|negative regulation of ferrous iron import across plasma membrane|negative regulation of ferrous iron import into cell http://purl.obolibrary.org/obo/GO_1904439 GO:1904438 biolink:BiologicalProcess regulation of iron ion import across plasma membrane Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane. go.json regulation of ferrous ion import into cell|regulation of ferrous iron import across plasma membrane|regulation of ferrous iron import into cell http://purl.obolibrary.org/obo/GO_1904438 GO:1904437 biolink:BiologicalProcess positive regulation of transferrin receptor binding Any process that activates or increases the frequency, rate or extent of transferrin receptor binding. go.json activation of transferrin receptor binding|up regulation of transferrin receptor binding|up-regulation of transferrin receptor binding|upregulation of transferrin receptor binding http://purl.obolibrary.org/obo/GO_1904437 gocheck_do_not_annotate GO:1904436 biolink:BiologicalProcess negative regulation of transferrin receptor binding Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding. go.json down regulation of transferrin receptor binding|down-regulation of transferrin receptor binding|downregulation of transferrin receptor binding|inhibition of transferrin receptor binding http://purl.obolibrary.org/obo/GO_1904436 gocheck_do_not_annotate GO:1904435 biolink:BiologicalProcess regulation of transferrin receptor binding Any process that modulates the frequency, rate or extent of transferrin receptor binding. go.json http://purl.obolibrary.org/obo/GO_1904435 gocheck_do_not_annotate GO:0062011 biolink:CellularComponent mitochondrial respiratory chain complex IV pre-assembly complex A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components. go.json COX pre-assemply complex|COX1 preassemply complex http://purl.obolibrary.org/obo/GO_0062011 GO:1904434 biolink:BiologicalProcess positive regulation of ferrous iron binding Any process that activates or increases the frequency, rate or extent of ferrous iron binding. go.json activation of ferrous iron binding|up regulation of ferrous iron binding|up-regulation of ferrous iron binding|upregulation of ferrous iron binding http://purl.obolibrary.org/obo/GO_1904434 gocheck_do_not_annotate GO:0062010 biolink:BiologicalProcess primitive palate development The biological process whose specific outcome is the progression of the primitive palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. go.json http://purl.obolibrary.org/obo/GO_0062010 GO:1904433 biolink:BiologicalProcess negative regulation of ferrous iron binding Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding. go.json down regulation of ferrous iron binding|down-regulation of ferrous iron binding|downregulation of ferrous iron binding|inhibition of ferrous iron binding http://purl.obolibrary.org/obo/GO_1904433 gocheck_do_not_annotate GO:0062013 biolink:BiologicalProcess positive regulation of small molecule metabolic process Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. go.json positive regulation of small molecule metabolism http://purl.obolibrary.org/obo/GO_0062013 GO:0062012 biolink:BiologicalProcess regulation of small molecule metabolic process Any process that modulates the rate, frequency or extent of a small molecule metabolic process. go.json regulation of small molecule metabolism http://purl.obolibrary.org/obo/GO_0062012 GO:1904432 biolink:BiologicalProcess regulation of ferrous iron binding Any process that modulates the frequency, rate or extent of ferrous iron binding. go.json http://purl.obolibrary.org/obo/GO_1904432 gocheck_do_not_annotate GO:1904442 biolink:BiologicalProcess negative regulation of thyroid gland epithelial cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation. go.json down regulation of Hurthle cell proliferation|down regulation of thyroid follicular cell proliferation|down regulation of thyroid gland epithelial cell proliferation|down-regulation of Hurthle cell proliferation|down-regulation of thyroid follicular cell proliferation|down-regulation of thyroid gland epithelial cell proliferation|downregulation of Hurthle cell proliferation|downregulation of thyroid follicular cell proliferation|downregulation of thyroid gland epithelial cell proliferation|inhibition of Hurthle cell proliferation|inhibition of thyroid follicular cell proliferation|inhibition of thyroid gland epithelial cell proliferation|negative regulation of Hurthle cell proliferation|negative regulation of thyroid follicular cell proliferation http://purl.obolibrary.org/obo/GO_1904442 GO:1904441 biolink:BiologicalProcess regulation of thyroid gland epithelial cell proliferation Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation. go.json regulation of Hurthle cell proliferation|regulation of thyroid follicular cell proliferation http://purl.obolibrary.org/obo/GO_1904441 GO:0062014 biolink:BiologicalProcess negative regulation of small molecule metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. go.json negative regulation of small molecule metabolism http://purl.obolibrary.org/obo/GO_0062014 GO:1904440 biolink:BiologicalProcess positive regulation of iron ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane. go.json activation of ferrous ion import into cell|activation of ferrous iron import across plasma membrane|positive regulation of ferrous ion import into cell|positive regulation of ferrous iron import across plasma membrane|positive regulation of ferrous iron import into cell|up regulation of ferrous ion import into cell|up regulation of ferrous iron import across plasma membrane|up-regulation of ferrous ion import into cell|up-regulation of ferrous iron import across plasma membrane|upregulation of ferrous ion import into cell|upregulation of ferrous iron import across plasma membrane http://purl.obolibrary.org/obo/GO_1904440 GO:0052681 biolink:MolecularActivity alpha-bisabolene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate. EC:4.2.3.38|KEGG_REACTION:R08370|MetaCyc:RXN-8550|RHEA:25436 go.json (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity|bisabolene synthase activity http://purl.obolibrary.org/obo/GO_0052681 GO:0003719 biolink:MolecularActivity obsolete transcription factor binding, cytoplasmic sequestering OBSOLETE. (Was not defined before being made obsolete). go.json transcription factor binding, cytoplasmic sequestering True http://purl.obolibrary.org/obo/GO_0003719 GO:0052680 biolink:MolecularActivity epi-isozizaene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate. EC:4.2.3.37|KEGG_REACTION:R07830|MetaCyc:RXN-9349|RHEA:25992 go.json (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity http://purl.obolibrary.org/obo/GO_0052680 GO:0003718 biolink:MolecularActivity obsolete RNA polymerase III transcription termination factor activity OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III. go.json Pol III transcription termination factor activity|RNA polymerase III transcription termination factor activity True http://purl.obolibrary.org/obo/GO_0003718 GO:0003715 biolink:MolecularActivity obsolete transcription termination factor activity OBSOLETE. Any activity that brings about termination of transcription. go.json transcription termination factor activity|transcriptional termination factor activity True http://purl.obolibrary.org/obo/GO_0003715 GO:0052685 biolink:MolecularActivity perillic acid-CoA ligase (ADP-forming) activity Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA. EC:6.2.1.-|KEGG_REACTION:R06367 go.json perillic acid:CoA ligase (ADP-forming) activity|perillyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0052685 GO:0003714 biolink:MolecularActivity transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. go.json RNA polymerase II transcription co-repressor activity|RNA polymerase II transcription corepressor activity|transcription co-repressor activity http://purl.obolibrary.org/obo/GO_0003714 GO:0052684 biolink:MolecularActivity L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O. EC:4.2.1.122|KEGG_REACTION:R00674|MetaCyc:RXN0-2382|RHEA:26434 go.json L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity|tryptophan synthase beta subunit activity http://purl.obolibrary.org/obo/GO_0052684 GO:0003717 biolink:MolecularActivity obsolete RNA polymerase II transcription termination factor activity OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II. go.json Pol II transcription termination factor activity|RNA polymerase II transcription termination factor activity True http://purl.obolibrary.org/obo/GO_0003717 GO:0052683 biolink:MolecularActivity (Z)-gamma-bisabolene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate. EC:4.2.3.40|MetaCyc:RXN-10005|RHEA:26081 go.json (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity http://purl.obolibrary.org/obo/GO_0052683 GO:0052682 biolink:MolecularActivity epi-cedrol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate. EC:4.2.3.39|KEGG_REACTION:R09140|MetaCyc:RXN-10004|RHEA:26115 go.json (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity|8-epicedrol synthase activity|epicedrol synthase activity http://purl.obolibrary.org/obo/GO_0052682 GO:0003716 biolink:MolecularActivity obsolete RNA polymerase I transcription termination factor activity OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I. go.json Pol I transcription termination factor activity|RNA polymerase I transcription termination factor activity True http://purl.obolibrary.org/obo/GO_0003716 GO:0052699 biolink:BiologicalProcess ergothioneine biosynthetic process The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. go.json (2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process|2-mercaptoergothioneine trimethylbetaine anabolism|2-mercaptoergothioneine trimethylbetaine biosynthesis|2-mercaptoergothioneine trimethylbetaine biosynthetic process|2-mercaptoergothioneine trimethylbetaine formation|2-mercaptoergothioneine trimethylbetaine synthesis|ergothioneine anabolism|ergothioneine biosynthesis|ergothioneine formation|ergothioneine synthesis http://purl.obolibrary.org/obo/GO_0052699 GO:0003721 biolink:MolecularActivity telomerase RNA reverse transcriptase activity Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. go.json telomerase, catalyst http://purl.obolibrary.org/obo/GO_0003721 GO:0003724 biolink:MolecularActivity RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis. EC:3.6.4.13|MetaCyc:RXN-11109|Reactome:R-HSA-72647|Reactome:R-HSA-9770129|Reactome:R-HSA-9770131|Reactome:R-HSA-9770141|Reactome:R-HSA-9770142|Reactome:R-HSA-9770145 go.json ATP-dependent RNA helicase activity http://purl.obolibrary.org/obo/GO_0003724 GO:0052698 biolink:BiologicalProcess ergothioneine metabolic process The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. go.json (2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate metabolic process|2-mercaptoergothioneine trimethylbetaine metabolic process|2-mercaptoergothioneine trimethylbetaine metabolism|ergothioneine metabolism http://purl.obolibrary.org/obo/GO_0052698 GO:0003723 biolink:MolecularActivity RNA binding Binding to an RNA molecule or a portion thereof. Reactome:R-HSA-203922 go.json base pairing with RNA|poly(A) RNA binding|poly(A)-RNA binding|poly-A RNA binding http://purl.obolibrary.org/obo/GO_0003723 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_plant|goslim_yeast|prokaryote_subset GO:0052697 biolink:BiologicalProcess xenobiotic glucuronidation The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. go.json phase II metabolism http://purl.obolibrary.org/obo/GO_0052697 GO:0003720 biolink:MolecularActivity telomerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. Reactome:R-HSA-163090|Reactome:R-HSA-164617 go.json http://purl.obolibrary.org/obo/GO_0003720 GO:1904449 biolink:BiologicalProcess negative regulation of aspartate secretion Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion. go.json down regulation of aspartate secretion|down-regulation of aspartate secretion|downregulation of aspartate secretion|inhibition of aspartate secretion http://purl.obolibrary.org/obo/GO_1904449 GO:1904448 biolink:BiologicalProcess regulation of aspartate secretion Any process that modulates the frequency, rate or extent of aspartate secretion. go.json http://purl.obolibrary.org/obo/GO_1904448 GO:1904447 biolink:BiologicalProcess folate import across plasma membrane The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol. go.json folate import into cell|folic acid import across plasma membrane http://purl.obolibrary.org/obo/GO_1904447 GO:1904446 biolink:BiologicalProcess positive regulation of establishment of Sertoli cell barrier Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier. go.json activation of establishment of BTB|activation of establishment of SCB|activation of establishment of Sertoli cell barrier|activation of establishment of blood-testis barrier|positive regulation of establishment of BTB|positive regulation of establishment of SCB|positive regulation of establishment of blood-testis barrier|up regulation of establishment of BTB|up regulation of establishment of SCB|up regulation of establishment of Sertoli cell barrier|up regulation of establishment of blood-testis barrier|up-regulation of establishment of BTB|up-regulation of establishment of SCB|up-regulation of establishment of Sertoli cell barrier|up-regulation of establishment of blood-testis barrier|upregulation of establishment of BTB|upregulation of establishment of SCB|upregulation of establishment of Sertoli cell barrier|upregulation of establishment of blood-testis barrier http://purl.obolibrary.org/obo/GO_1904446 GO:0062000 biolink:BiologicalProcess positive regulation of cardiac endothelial to mesenchymal transition Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition. go.json http://purl.obolibrary.org/obo/GO_0062000 GO:1904445 biolink:BiologicalProcess negative regulation of establishment of Sertoli cell barrier Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier. go.json down regulation of establishment of BTB|down regulation of establishment of SCB|down regulation of establishment of Sertoli cell barrier|down regulation of establishment of blood-testis barrier|down-regulation of establishment of BTB|down-regulation of establishment of SCB|down-regulation of establishment of Sertoli cell barrier|down-regulation of establishment of blood-testis barrier|downregulation of establishment of BTB|downregulation of establishment of SCB|downregulation of establishment of Sertoli cell barrier|downregulation of establishment of blood-testis barrier|inhibition of establishment of BTB|inhibition of establishment of SCB|inhibition of establishment of Sertoli cell barrier|inhibition of establishment of blood-testis barrier|negative regulation of establishment of BTB|negative regulation of establishment of SCB|negative regulation of establishment of blood-testis barrier http://purl.obolibrary.org/obo/GO_1904445 GO:0062002 biolink:BiologicalProcess regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Any process that modulates the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. go.json http://purl.obolibrary.org/obo/GO_0062002 gocheck_do_not_annotate GO:1904444 biolink:BiologicalProcess regulation of establishment of Sertoli cell barrier Any process that modulates the frequency, rate or extent of establishment of Sertoli cell barrier. go.json regulation of establishment of BTB|regulation of establishment of SCB|regulation of establishment of blood-testis barrier http://purl.obolibrary.org/obo/GO_1904444 GO:1904443 biolink:BiologicalProcess positive regulation of thyroid gland epithelial cell proliferation Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation. go.json activation of Hurthle cell proliferation|activation of thyroid follicular cell proliferation|activation of thyroid gland epithelial cell proliferation|positive regulation of Hurthle cell proliferation|positive regulation of thyroid follicular cell proliferation|up regulation of Hurthle cell proliferation|up regulation of thyroid follicular cell proliferation|up regulation of thyroid gland epithelial cell proliferation|up-regulation of Hurthle cell proliferation|up-regulation of thyroid follicular cell proliferation|up-regulation of thyroid gland epithelial cell proliferation|upregulation of Hurthle cell proliferation|upregulation of thyroid follicular cell proliferation|upregulation of thyroid gland epithelial cell proliferation http://purl.obolibrary.org/obo/GO_1904443 GO:0062001 biolink:BiologicalProcess negative regulation of cardiac endothelial to mesenchymal transition Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition. go.json http://purl.obolibrary.org/obo/GO_0062001 GO:1904453 biolink:BiologicalProcess positive regulation of potassium:proton exchanging ATPase activity Any process that activates or increases the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. go.json activation of (K+ + H+)-ATPase activity|activation of ATP phosphohydrolase (H+/K+-exchanging)|activation of H+-K+-ATPase activity|activation of H+/K(+)-ATPase activity|activation of H+/K(+)-exchanging ATPase activity|activation of H+/K+-ATPase activity|activation of H+/K+-exchanging ATPase activity|activation of H,K-ATPase activity|activation of gastric H+/K(+) ATPase activity|activation of gastric H+/K+ ATPase|activation of hydrogen/potassium-exchanging ATPase activity|activation of hydrogen:potassium exchanging ATPase activity|activation of hydrogen:potassium-exchanging ATPase activity|positive regulation of (K+ + H+)-ATPase activity|positive regulation of ATP phosphohydrolase (H+/K+-exchanging)|positive regulation of H+-K+-ATPase activity|positive regulation of H+/K(+)-ATPase activity|positive regulation of H+/K(+)-exchanging ATPase activity|positive regulation of H+/K+-ATPase activity|positive regulation of H+/K+-exchanging ATPase activity|positive regulation of H,K-ATPase activity|positive regulation of gastric H+/K(+) ATPase activity|positive regulation of gastric H+/K+ ATPase|positive regulation of hydrogen/potassium-exchanging ATPase activity|positive regulation of hydrogen:potassium exchanging ATPase activity|positive regulation of hydrogen:potassium-exchanging ATPase activity|up regulation of (K+ + H+)-ATPase activity|up regulation of ATP phosphohydrolase (H+/K+-exchanging)|up regulation of H+-K+-ATPase activity|up regulation of H+/K(+)-ATPase activity|up regulation of H+/K(+)-exchanging ATPase activity|up regulation of H+/K+-ATPase activity|up regulation of H+/K+-exchanging ATPase activity|up regulation of H,K-ATPase activity|up regulation of gastric H+/K(+) ATPase activity|up regulation of gastric H+/K+ ATPase|up regulation of hydrogen/potassium-exchanging ATPase activity|up regulation of hydrogen:potassium exchanging ATPase activity|up regulation of hydrogen:potassium-exchanging ATPase activity|up-regulation of (K+ + H+)-ATPase activity|up-regulation of ATP phosphohydrolase (H+/K+-exchanging)|up-regulation of H+-K+-ATPase activity|up-regulation of H+/K(+)-ATPase activity|up-regulation of H+/K(+)-exchanging ATPase activity|up-regulation of H+/K+-ATPase activity|up-regulation of H+/K+-exchanging ATPase activity|up-regulation of H,K-ATPase activity|up-regulation of gastric H+/K(+) ATPase activity|up-regulation of gastric H+/K+ ATPase|up-regulation of hydrogen/potassium-exchanging ATPase activity|up-regulation of hydrogen:potassium exchanging ATPase activity|up-regulation of hydrogen:potassium-exchanging ATPase activity|upregulation of (K+ + H+)-ATPase activity|upregulation of ATP phosphohydrolase (H+/K+-exchanging)|upregulation of H+-K+-ATPase activity|upregulation of H+/K(+)-ATPase activity|upregulation of H+/K(+)-exchanging ATPase activity|upregulation of H+/K+-ATPase activity|upregulation of H+/K+-exchanging ATPase activity|upregulation of H,K-ATPase activity|upregulation of gastric H+/K(+) ATPase activity|upregulation of gastric H+/K+ ATPase|upregulation of hydrogen/potassium-exchanging ATPase activity|upregulation of hydrogen:potassium exchanging ATPase activity|upregulation of hydrogen:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_1904453 gocheck_do_not_annotate GO:1904452 biolink:BiologicalProcess negative regulation of potassium:proton exchanging ATPase activity Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. go.json down regulation of (K+ + H+)-ATPase activity|down regulation of ATP phosphohydrolase (H+/K+-exchanging)|down regulation of H+-K+-ATPase activity|down regulation of H+/K(+)-ATPase activity|down regulation of H+/K(+)-exchanging ATPase activity|down regulation of H+/K+-ATPase activity|down regulation of H+/K+-exchanging ATPase activity|down regulation of H,K-ATPase activity|down regulation of gastric H+/K(+) ATPase activity|down regulation of gastric H+/K+ ATPase|down regulation of hydrogen/potassium-exchanging ATPase activity|down regulation of hydrogen:potassium exchanging ATPase activity|down regulation of hydrogen:potassium-exchanging ATPase activity|down-regulation of (K+ + H+)-ATPase activity|down-regulation of ATP phosphohydrolase (H+/K+-exchanging)|down-regulation of H+-K+-ATPase activity|down-regulation of H+/K(+)-ATPase activity|down-regulation of H+/K(+)-exchanging ATPase activity|down-regulation of H+/K+-ATPase activity|down-regulation of H+/K+-exchanging ATPase activity|down-regulation of H,K-ATPase activity|down-regulation of gastric H+/K(+) ATPase activity|down-regulation of gastric H+/K+ ATPase|down-regulation of hydrogen/potassium-exchanging ATPase activity|down-regulation of hydrogen:potassium exchanging ATPase activity|down-regulation of hydrogen:potassium-exchanging ATPase activity|downregulation of (K+ + H+)-ATPase activity|downregulation of ATP phosphohydrolase (H+/K+-exchanging)|downregulation of H+-K+-ATPase activity|downregulation of H+/K(+)-ATPase activity|downregulation of H+/K(+)-exchanging ATPase activity|downregulation of H+/K+-ATPase activity|downregulation of H+/K+-exchanging ATPase activity|downregulation of H,K-ATPase activity|downregulation of gastric H+/K(+) ATPase activity|downregulation of gastric H+/K+ ATPase|downregulation of hydrogen/potassium-exchanging ATPase activity|downregulation of hydrogen:potassium exchanging ATPase activity|downregulation of hydrogen:potassium-exchanging ATPase activity|inhibition of (K+ + H+)-ATPase activity|inhibition of ATP phosphohydrolase (H+/K+-exchanging)|inhibition of H+-K+-ATPase activity|inhibition of H+/K(+)-ATPase activity|inhibition of H+/K(+)-exchanging ATPase activity|inhibition of H+/K+-ATPase activity|inhibition of H+/K+-exchanging ATPase activity|inhibition of H,K-ATPase activity|inhibition of gastric H+/K(+) ATPase activity|inhibition of gastric H+/K+ ATPase|inhibition of hydrogen/potassium-exchanging ATPase activity|inhibition of hydrogen:potassium exchanging ATPase activity|inhibition of hydrogen:potassium-exchanging ATPase activity|negative regulation of (K+ + H+)-ATPase activity|negative regulation of ATP phosphohydrolase (H+/K+-exchanging)|negative regulation of H+-K+-ATPase activity|negative regulation of H+/K(+)-ATPase activity|negative regulation of H+/K(+)-exchanging ATPase activity|negative regulation of H+/K+-ATPase activity|negative regulation of H+/K+-exchanging ATPase activity|negative regulation of H,K-ATPase activity|negative regulation of gastric H+/K(+) ATPase activity|negative regulation of gastric H+/K+ ATPase|negative regulation of hydrogen/potassium-exchanging ATPase activity|negative regulation of hydrogen:potassium exchanging ATPase activity|negative regulation of hydrogen:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_1904452 gocheck_do_not_annotate GO:0062003 biolink:BiologicalProcess negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. go.json http://purl.obolibrary.org/obo/GO_0062003 gocheck_do_not_annotate GO:1904451 biolink:BiologicalProcess regulation of potassium:proton exchanging ATPase activity Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. go.json regulation of (K+ + H+)-ATPase activity|regulation of ATP phosphohydrolase (H+/K+-exchanging)|regulation of H+-K+-ATPase activity|regulation of H+/K(+)-ATPase activity|regulation of H+/K(+)-exchanging ATPase activity|regulation of H+/K+-ATPase activity|regulation of H+/K+-exchanging ATPase activity|regulation of H,K-ATPase activity|regulation of gastric H+/K(+) ATPase activity|regulation of gastric H+/K+ ATPase|regulation of hydrogen/potassium-exchanging ATPase activity|regulation of hydrogen:potassium exchanging ATPase activity|regulation of hydrogen:potassium-exchanging ATPase activity|regulation of proton pump activity http://purl.obolibrary.org/obo/GO_1904451 gocheck_do_not_annotate GO:1904450 biolink:BiologicalProcess positive regulation of aspartate secretion Any process that activates or increases the frequency, rate or extent of aspartate secretion. go.json activation of aspartate secretion|up regulation of aspartate secretion|up-regulation of aspartate secretion|upregulation of aspartate secretion http://purl.obolibrary.org/obo/GO_1904450 GO:0062009 biolink:BiologicalProcess secondary palate development The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences. go.json http://purl.obolibrary.org/obo/GO_0062009 GO:0052692 biolink:MolecularActivity raffinose alpha-galactosidase activity Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose. KEGG_REACTION:R01103|MetaCyc:RXN-11502|RHEA:70275 go.json alkaline alpha-galactosidase activity|raffinose galactohydrolase activity|raffinose-specific alkaline alpha-galactosidase activity http://purl.obolibrary.org/obo/GO_0052692 GO:0003729 biolink:MolecularActivity mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. go.json base pairing with mRNA http://purl.obolibrary.org/obo/GO_0003729 goslim_chembl|goslim_yeast GO:0052691 biolink:MolecularActivity UDP-arabinopyranose mutase activity Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose. EC:5.4.99.30|MetaCyc:RXN-11552|RHEA:28350 go.json UDP-L-Ara mutase activity|UDP-L-arabinopyranose furanomutase activity|UDP-L-arabinose mutase activity|UDP-arabinopyranose pyranomutase activity|uridine-diphosphate-L-arabinose mutase activity http://purl.obolibrary.org/obo/GO_0052691 GO:0052690 biolink:MolecularActivity trichloro-p-hydroquinone reductive dehalogenase activity Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl. RHEA:56832|UM-BBD_reactionID:r0315 go.json pentaerythritol tetranitrate reductase activity|tetrachlorohydroquinone reductive dehalogenase activity|trichlorohydroquinone reductive dehalogenase activity|xenobiotic reductase activity http://purl.obolibrary.org/obo/GO_0052690 GO:0003726 biolink:MolecularActivity double-stranded RNA adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. EC:3.5.4.37|RHEA:10120|Reactome:R-HSA-77614|Reactome:R-HSA-77615 go.json double-stranded RNA specific editase activity http://purl.obolibrary.org/obo/GO_0003726 GO:0052696 biolink:BiologicalProcess flavonoid glucuronidation The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. go.json flavonoid glucuronide biosynthesis|flavonoid glucuronide biosynthetic process|flavonoid glucuronoside biosynthesis|flavonoid glucuronoside biosynthetic process http://purl.obolibrary.org/obo/GO_0052696 GO:0003725 biolink:MolecularActivity double-stranded RNA binding Binding to double-stranded RNA. go.json dsRNA binding http://purl.obolibrary.org/obo/GO_0003725 GO:0052695 biolink:BiologicalProcess cellular glucuronidation The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. go.json cellular glucuronide biosynthesis|cellular glucuronide biosynthetic process|cellular glucuronoside biosynthesis|cellular glucuronoside biosynthetic process http://purl.obolibrary.org/obo/GO_0052695 GO:0052694 biolink:MolecularActivity jasmonoyl-isoleucine-12-hydroxylase activity Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O. MetaCyc:RXN-12421|RHEA:54808 go.json http://purl.obolibrary.org/obo/GO_0052694 GO:0003728 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003728 GO:0052693 biolink:MolecularActivity epoxyqueuosine reductase activity Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant. EC:1.17.99.6|RHEA:32159 go.json http://purl.obolibrary.org/obo/GO_0052693 GO:0003727 biolink:MolecularActivity single-stranded RNA binding Binding to single-stranded RNA. go.json ssRNA binding http://purl.obolibrary.org/obo/GO_0003727 GO:0062031 biolink:BiologicalProcess filamentous growth MAPK cascade The MAPK cascade which is activated as a result of partial nutrient deprivation and which results in filamentous growth. go.json http://purl.obolibrary.org/obo/GO_0062031 GO:1904459 biolink:BiologicalProcess negative regulation of substance P secretion Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion. go.json down regulation of substance P secretion|down-regulation of substance P secretion|downregulation of substance P secretion|inhibition of substance P secretion http://purl.obolibrary.org/obo/GO_1904459 GO:0062030 biolink:BiologicalProcess negative regulation of stress granule assembly Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. go.json http://purl.obolibrary.org/obo/GO_0062030 GO:1904458 biolink:BiologicalProcess regulation of substance P secretion Any process that modulates the frequency, rate or extent of substance P secretion. go.json http://purl.obolibrary.org/obo/GO_1904458 GO:1904457 biolink:BiologicalProcess positive regulation of neuronal action potential Any process that activates or increases the frequency, rate or extent of neuronal action potential. go.json activation of generation of action potential|activation of neuronal action potential|positive regulation of generation of action potential|up regulation of generation of action potential|up regulation of neuronal action potential|up-regulation of generation of action potential|up-regulation of neuronal action potential|upregulation of generation of action potential|upregulation of neuronal action potential http://purl.obolibrary.org/obo/GO_1904457 GO:0062033 biolink:BiologicalProcess positive regulation of mitotic sister chromatid segregation Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. go.json http://purl.obolibrary.org/obo/GO_0062033 GO:0062032 biolink:BiologicalProcess cichorine biosynthetic process The chemical reactions and pathways resulting in the formation of cichorine, a secondary metabolite found in some species of fungi. go.json cichorine anabolism|cichorine biosynthesis|cichorine formation|cichorine synthesis http://purl.obolibrary.org/obo/GO_0062032 GO:1904456 biolink:BiologicalProcess negative regulation of neuronal action potential Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. go.json down regulation of generation of action potential|down regulation of neuronal action potential|down-regulation of generation of action potential|down-regulation of neuronal action potential|downregulation of generation of action potential|downregulation of neuronal action potential|inhibition of generation of action potential|inhibition of neuronal action potential|negative regulation of generation of action potential http://purl.obolibrary.org/obo/GO_1904456 GO:0062035 biolink:BiologicalProcess sensory perception of cold stimulus The series of events required for an organism to receive a cold temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. go.json http://purl.obolibrary.org/obo/GO_0062035 GO:1904455 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904455 GO:1904454 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904454 GO:0062034 biolink:BiologicalProcess L-pipecolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of L-pipecolic acid, a metabolite of lysine. go.json L-pipecolate biosynthetic process http://purl.obolibrary.org/obo/GO_0062034 GO:1904464 biolink:BiologicalProcess regulation of matrix metallopeptidase secretion Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion. go.json regulation of MMP secretion|regulation of matrix metalloproteinase secretion http://purl.obolibrary.org/obo/GO_1904464 GO:0062037 biolink:MolecularActivity D-loop DNA binding Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind. go.json DNA displacement loop binding http://purl.obolibrary.org/obo/GO_0062037 GO:1904463 biolink:BiologicalProcess ergosteryl 3-beta-D-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of ergosteryl 3-beta-D-glucoside. go.json ergosteryl 3-beta-D-glucoside anabolism|ergosteryl 3-beta-D-glucoside biosynthesis|ergosteryl 3-beta-D-glucoside formation|ergosteryl 3-beta-D-glucoside synthesis http://purl.obolibrary.org/obo/GO_1904463 GO:0062036 biolink:BiologicalProcess sensory perception of hot stimulus The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. go.json http://purl.obolibrary.org/obo/GO_0062036 GO:1904462 biolink:BiologicalProcess ergosteryl 3-beta-D-glucoside catabolic process The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside. go.json ergosteryl 3-beta-D-glucoside breakdown|ergosteryl 3-beta-D-glucoside catabolism|ergosteryl 3-beta-D-glucoside degradation http://purl.obolibrary.org/obo/GO_1904462 GO:0062039 biolink:CellularComponent biofilm matrix A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells. go.json http://purl.obolibrary.org/obo/GO_0062039 GO:1904461 biolink:BiologicalProcess ergosteryl 3-beta-D-glucoside metabolic process The chemical reactions and pathways involving ergosteryl 3-beta-D-glucoside. go.json ergosteryl 3-beta-D-glucoside metabolism http://purl.obolibrary.org/obo/GO_1904461 GO:0062038 biolink:BiologicalProcess positive regulation of pheromone response MAPK cascade Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade. go.json http://purl.obolibrary.org/obo/GO_0062038 GO:1904460 biolink:BiologicalProcess positive regulation of substance P secretion Any process that activates or increases the frequency, rate or extent of substance P secretion. go.json activation of substance P secretion|up regulation of substance P secretion|up-regulation of substance P secretion|upregulation of substance P secretion http://purl.obolibrary.org/obo/GO_1904460 GO:0003700 biolink:MolecularActivity DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. go.json DNA binding transcription factor activity|bacterial-type DNA binding transcription factor activity|bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity|bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity|bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding|gene-specific transcription factor activity|metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity|metal ion regulated sequence-specific DNA binding transcription factor activity|nucleic acid binding transcription factor activity|sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor activity|transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding|transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding|transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding|transcription factor activity, metal ion regulated sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0003700 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_mouse|goslim_plant|goslim_yeast GO:0003702 biolink:MolecularActivity obsolete RNA polymerase II transcription factor activity OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription. go.json RNA polymerase II transcription factor activity True http://purl.obolibrary.org/obo/GO_0003702 GO:0003701 biolink:MolecularActivity obsolete RNA polymerase I transcription factor activity OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription. go.json RNA polymerase I transcription factor activity True http://purl.obolibrary.org/obo/GO_0003701 GO:1904469 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904469 GO:0062022 biolink:BiologicalProcess mitotic cohesin ssDNA (lagging strand) loading The ATP-dependent protein localization to chromatin by which a cohesin ring complex is topologically linked to ssDNA (lagging strand) which is already linked to a dsDNA (leading strand) molecule as part of the mitotic cell cycle. go.json second-DNA capture http://purl.obolibrary.org/obo/GO_0062022 GO:1904468 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904468 GO:0062021 biolink:BiologicalProcess mitotic cohesin dsDNA (leading strand) loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to dsDNA (leading strand) as part of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0062021 GO:1904467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904467 GO:1904466 biolink:BiologicalProcess positive regulation of matrix metallopeptidase secretion Any process that activates or increases the frequency, rate or extent of matrix metallopeptidase secretion. go.json activation of MMP secretion|activation of matrix metallopeptidase secretion|activation of matrix metalloproteinase secretion|positive regulation of MMP secretion|positive regulation of matrix metalloproteinase secretion|up regulation of MMP secretion|up regulation of matrix metallopeptidase secretion|up regulation of matrix metalloproteinase secretion|up-regulation of MMP secretion|up-regulation of matrix metallopeptidase secretion|up-regulation of matrix metalloproteinase secretion|upregulation of MMP secretion|upregulation of matrix metallopeptidase secretion|upregulation of matrix metalloproteinase secretion http://purl.obolibrary.org/obo/GO_1904466 GO:1904465 biolink:BiologicalProcess negative regulation of matrix metallopeptidase secretion Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion. go.json down regulation of MMP secretion|down regulation of matrix metallopeptidase secretion|down regulation of matrix metalloproteinase secretion|down-regulation of MMP secretion|down-regulation of matrix metallopeptidase secretion|down-regulation of matrix metalloproteinase secretion|downregulation of MMP secretion|downregulation of matrix metallopeptidase secretion|downregulation of matrix metalloproteinase secretion|inhibition of MMP secretion|inhibition of matrix metallopeptidase secretion|inhibition of matrix metalloproteinase secretion|negative regulation of MMP secretion|negative regulation of matrix metalloproteinase secretion http://purl.obolibrary.org/obo/GO_1904465 GO:0062023 biolink:CellularComponent collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. go.json http://purl.obolibrary.org/obo/GO_0062023 GO:1904475 biolink:BiologicalProcess regulation of small GTPase binding Any process that modulates the frequency, rate or extent of small GTPase binding. go.json regulation of Ras GTPase binding http://purl.obolibrary.org/obo/GO_1904475 gocheck_do_not_annotate GO:0062026 biolink:BiologicalProcess negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. go.json http://purl.obolibrary.org/obo/GO_0062026 GO:1904474 biolink:BiologicalProcess cellular response to L-dopa Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus. go.json http://purl.obolibrary.org/obo/GO_1904474 GO:0062025 biolink:BiologicalProcess regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. go.json http://purl.obolibrary.org/obo/GO_0062025 GO:0062028 biolink:BiologicalProcess regulation of stress granule assembly Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. go.json http://purl.obolibrary.org/obo/GO_0062028 GO:1904473 biolink:BiologicalProcess response to L-dopa Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus. go.json http://purl.obolibrary.org/obo/GO_1904473 GO:1904472 biolink:BiologicalProcess positive regulation of endothelin production Any process that activates or increases the frequency, rate or extent of endothelin production. go.json activation of EDN1 secretion|activation of EDN2 secretion|activation of EDN3 secretion|activation of endothelin secretion|activation of endothelin-1 secretion|activation of endothelin-2 secretion|activation of endothelin-3 secretion|positive regulation of EDN1 secretion|positive regulation of EDN2 secretion|positive regulation of EDN3 secretion|positive regulation of endothelin secretion|positive regulation of endothelin-1 secretion|positive regulation of endothelin-2 secretion|positive regulation of endothelin-3 secretion|up regulation of EDN1 secretion|up regulation of EDN2 secretion|up regulation of EDN3 secretion|up regulation of endothelin secretion|up regulation of endothelin-1 secretion|up regulation of endothelin-2 secretion|up regulation of endothelin-3 secretion|up-regulation of EDN1 secretion|up-regulation of EDN2 secretion|up-regulation of EDN3 secretion|up-regulation of endothelin secretion|up-regulation of endothelin-1 secretion|up-regulation of endothelin-2 secretion|up-regulation of endothelin-3 secretion|upregulation of EDN1 secretion|upregulation of EDN2 secretion|upregulation of EDN3 secretion|upregulation of endothelin secretion|upregulation of endothelin-1 secretion|upregulation of endothelin-2 secretion|upregulation of endothelin-3 secretion http://purl.obolibrary.org/obo/GO_1904472 GO:0062027 biolink:BiologicalProcess positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. go.json http://purl.obolibrary.org/obo/GO_0062027 GO:1904471 biolink:BiologicalProcess negative regulation of endothelin production Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production. go.json down regulation of EDN1 secretion|down regulation of EDN2 secretion|down regulation of EDN3 secretion|down regulation of endothelin secretion|down regulation of endothelin-1 secretion|down regulation of endothelin-2 secretion|down regulation of endothelin-3 secretion|down-regulation of EDN1 secretion|down-regulation of EDN2 secretion|down-regulation of EDN3 secretion|down-regulation of endothelin secretion|down-regulation of endothelin-1 secretion|down-regulation of endothelin-2 secretion|down-regulation of endothelin-3 secretion|downregulation of EDN1 secretion|downregulation of EDN2 secretion|downregulation of EDN3 secretion|downregulation of endothelin secretion|downregulation of endothelin-1 secretion|downregulation of endothelin-2 secretion|downregulation of endothelin-3 secretion|inhibition of EDN1 secretion|inhibition of EDN2 secretion|inhibition of EDN3 secretion|inhibition of endothelin secretion|inhibition of endothelin-1 secretion|inhibition of endothelin-2 secretion|inhibition of endothelin-3 secretion|negative regulation of EDN1 secretion|negative regulation of EDN2 secretion|negative regulation of EDN3 secretion|negative regulation of endothelin secretion|negative regulation of endothelin-1 secretion|negative regulation of endothelin-2 secretion|negative regulation of endothelin-3 secretion http://purl.obolibrary.org/obo/GO_1904471 GO:1904470 biolink:BiologicalProcess regulation of endothelin production Any process that modulates the frequency, rate or extent of endothelin production. go.json regulation of EDN1 secretion|regulation of EDN2 secretion|regulation of EDN3 secretion|regulation of endothelin secretion|regulation of endothelin-1 secretion|regulation of endothelin-2 secretion|regulation of endothelin-3 secretion http://purl.obolibrary.org/obo/GO_1904470 GO:0062029 biolink:BiologicalProcess positive regulation of stress granule assembly Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. go.json http://purl.obolibrary.org/obo/GO_0062029 GO:0003708 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003708 GO:0003707 biolink:MolecularActivity nuclear steroid receptor activity Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. go.json steroid hormone receptor activity http://purl.obolibrary.org/obo/GO_0003707 GO:0003709 biolink:MolecularActivity obsolete RNA polymerase III transcription factor activity OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription. go.json RNA polymerase III transcription factor activity True http://purl.obolibrary.org/obo/GO_0003709 GO:0003704 biolink:MolecularActivity obsolete specific RNA polymerase II transcription factor activity OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II. go.json specific RNA polymerase II transcription factor activity True http://purl.obolibrary.org/obo/GO_0003704 GO:0003703 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003703 GO:0003706 biolink:MolecularActivity obsolete ligand-regulated transcription factor activity OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand. go.json ligand-regulated transcription factor activity True http://purl.obolibrary.org/obo/GO_0003706 GO:0003705 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003705 GO:0062051 biolink:CellularComponent lipopolysaccharide transport system A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner. go.json http://purl.obolibrary.org/obo/GO_0062051 GO:0062050 biolink:MolecularActivity GPI-mannose ethanolamine phosphate phosphodiesterase activity A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor. go.json http://purl.obolibrary.org/obo/GO_0062050 GO:0062052 biolink:BiologicalProcess starch granule initiation The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts. go.json http://purl.obolibrary.org/obo/GO_0062052 GO:0086019 biolink:BiologicalProcess cell-cell signaling involved in cardiac conduction Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. go.json cell-cell signalling involved in cardiac conduction http://purl.obolibrary.org/obo/GO_0086019 GO:0062055 biolink:BiologicalProcess photosynthetic state transition A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems. go.json http://purl.obolibrary.org/obo/GO_0062055 GO:1904479 biolink:BiologicalProcess negative regulation of intestinal absorption Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption. go.json down regulation of intestinal absorption|down-regulation of intestinal absorption|downregulation of intestinal absorption|inhibition of intestinal absorption http://purl.obolibrary.org/obo/GO_1904479 GO:0062054 biolink:MolecularActivity fluoride channel activity Enables the facilitated diffusion of fluoride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. go.json http://purl.obolibrary.org/obo/GO_0062054 GO:0086018 biolink:BiologicalProcess SA node cell to atrial cardiac muscle cell signaling Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. go.json SA node cardiac muscle cell to atrial cardiac muscle cell signalling|SA node cardiomyocyte to atrial cardiomyocyte signalling|SAN cardiomyocyte to atrial cardiomyocyte signalling|sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling|sinus node cardiomyocyte to atrial cardiomyocyte signalling http://purl.obolibrary.org/obo/GO_0086018 GO:1904478 biolink:BiologicalProcess regulation of intestinal absorption Any process that modulates the frequency, rate or extent of intestinal absorption. go.json http://purl.obolibrary.org/obo/GO_1904478 GO:1904477 biolink:BiologicalProcess positive regulation of small GTPase binding Any process that activates or increases the frequency, rate or extent of small GTPase binding. go.json activation of Ras GTPase binding|positive regulation of Ras GTPase binding|up regulation of small GTPase binding|up-regulation of small GTPase binding|upregulation of small GTPase binding http://purl.obolibrary.org/obo/GO_1904477 gocheck_do_not_annotate GO:0086017 biolink:BiologicalProcess Purkinje myocyte action potential An action potential that occurs in a Purkinje myocyte. go.json http://purl.obolibrary.org/obo/GO_0086017 GO:0062057 biolink:MolecularActivity L-aspartate:fumarate antiporter activity Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out). go.json http://purl.obolibrary.org/obo/GO_0062057 GO:1904476 biolink:BiologicalProcess negative regulation of small GTPase binding Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding. go.json down regulation of small GTPase binding|down-regulation of Ras GTPase binding|downregulation of small GTPase binding|inhibition of small GTPase binding|negative regulation of Ras GTPase binding http://purl.obolibrary.org/obo/GO_1904476 gocheck_do_not_annotate GO:0062056 biolink:BiologicalProcess compound eye pigment cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia. go.json http://purl.obolibrary.org/obo/GO_0062056 GO:0086016 biolink:BiologicalProcess AV node cell action potential An action potential that occurs in an atrioventricular node cardiac muscle cell. go.json AV node cardiac muscle cell action potential|atrioventricular node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086016 GO:0086015 biolink:BiologicalProcess SA node cell action potential An action potential that occurs in a sinoatrial node cardiac muscle cell. go.json SA node cardiac muscle cell action potential|SAN cardiac muscle cell action potential|sinoatrial node cardiac muscle cell action potential|sinus node cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_0086015 GO:1904486 biolink:BiologicalProcess obsolete response to 17alpha-ethynylestradiol OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904486 GO:0062059 biolink:MolecularActivity FACT complex binding Binding to a FACT complex. go.json http://purl.obolibrary.org/obo/GO_0062059 GO:0086014 biolink:BiologicalProcess atrial cardiac muscle cell action potential An action potential that occurs in an atrial cardiac muscle cell. go.json http://purl.obolibrary.org/obo/GO_0086014 GO:0062058 biolink:MolecularActivity transcription factor TFIIH holo complex binding Binding to a transcription factor TFIIH holo complex. go.json http://purl.obolibrary.org/obo/GO_0062058 GO:1904484 biolink:BiologicalProcess cloacal gland development The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_1904484 GO:0086013 biolink:BiologicalProcess membrane repolarization during cardiac muscle cell action potential The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0086013 GO:1904483 biolink:MolecularActivity synthetic cannabinoid binding Binding to synthetic cannabinoid. go.json http://purl.obolibrary.org/obo/GO_1904483 GO:0086012 biolink:BiologicalProcess membrane depolarization during cardiac muscle cell action potential The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json http://purl.obolibrary.org/obo/GO_0086012 GO:1904482 biolink:BiologicalProcess cellular response to tetrahydrofolate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus. go.json http://purl.obolibrary.org/obo/GO_1904482 GO:0086011 biolink:BiologicalProcess membrane repolarization during action potential The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0086011 GO:1904481 biolink:BiologicalProcess response to tetrahydrofolate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus. go.json http://purl.obolibrary.org/obo/GO_1904481 GO:0086010 biolink:BiologicalProcess membrane depolarization during action potential The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. go.json http://purl.obolibrary.org/obo/GO_0086010 GO:1904480 biolink:BiologicalProcess positive regulation of intestinal absorption Any process that activates or increases the frequency, rate or extent of intestinal absorption. go.json activation of intestinal absorption|up regulation of intestinal absorption|up-regulation of intestinal absorption|upregulation of intestinal absorption http://purl.obolibrary.org/obo/GO_1904480 GO:0062040 biolink:CellularComponent fungal biofilm matrix An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses. go.json http://purl.obolibrary.org/obo/GO_0062040 GO:0062042 biolink:BiologicalProcess regulation of cardiac epithelial to mesenchymal transition Any process that modulates the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0062042 GO:0062041 biolink:BiologicalProcess positive regulation of meiotic sister chromatid arm separation Any process that increases the rate or exent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis. go.json http://purl.obolibrary.org/obo/GO_0062041 GO:0086009 biolink:BiologicalProcess membrane repolarization The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. go.json http://purl.obolibrary.org/obo/GO_0086009 GO:0086008 biolink:MolecularActivity voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086008 GO:0062044 biolink:BiologicalProcess negative regulation of cardiac epithelial to mesenchymal transition Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0062044 GO:1904489 biolink:BiologicalProcess obsolete regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process. go.json regulation of ROS metabolic process by down regulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by down regulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by down-regulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by down-regulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by downregulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by downregulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by inhibition of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by inhibition of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter|regulation of ROS metabolic process by negative regulation of global transcription from Pol II promoter|regulation of ROS metabolic process by negative regulation of transcription from Pol II promoter|regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter, global|regulation of reactive oxygen species metabolic process by down regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by down regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by down-regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by down-regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by downregulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by downregulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by inhibition of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by inhibition of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by negative regulation of global transcription from Pol II promoter|regulation of reactive oxygen species metabolic process by negative regulation of transcription from Pol II promoter|regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter, global|regulation of reactive oxygen species metabolism by down regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by down regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by down-regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by down-regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by downregulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by downregulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by inhibition of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by inhibition of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by negative regulation of gene-specific transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by negative regulation of global transcription from Pol II promoter|regulation of reactive oxygen species metabolism by negative regulation of transcription from Pol II promoter|regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter, global True http://purl.obolibrary.org/obo/GO_1904489 GO:0062043 biolink:BiologicalProcess positive regulation of cardiac epithelial to mesenchymal transition Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. go.json http://purl.obolibrary.org/obo/GO_0062043 GO:0086007 biolink:MolecularActivity voltage-gated calcium channel activity involved in cardiac muscle cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086007 GO:1904488 biolink:BiologicalProcess obsolete regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process. go.json regulation of ROS metabolic process by activation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by activation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter|regulation of ROS metabolic process by positive regulation of global transcription from Pol II promoter|regulation of ROS metabolic process by positive regulation of transcription from Pol II promoter|regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter, global|regulation of ROS metabolic process by stimulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by stimulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by up regulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by up regulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by up-regulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by up-regulation of transcription from RNA polymerase II promoter|regulation of ROS metabolic process by upregulation of global transcription from RNA polymerase II promoter|regulation of ROS metabolic process by upregulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by activation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by activation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by positive regulation of global transcription from Pol II promoter|regulation of reactive oxygen species metabolic process by positive regulation of transcription from Pol II promoter|regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter, global|regulation of reactive oxygen species metabolic process by stimulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by stimulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by up regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by up regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by up-regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by up-regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by upregulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolic process by upregulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by activation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by activation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by positive regulation of gene-specific transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by positive regulation of global transcription from Pol II promoter|regulation of reactive oxygen species metabolism by positive regulation of transcription from Pol II promoter|regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter, global|regulation of reactive oxygen species metabolism by stimulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by stimulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by up regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by up regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by up-regulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by up-regulation of transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by upregulation of global transcription from RNA polymerase II promoter|regulation of reactive oxygen species metabolism by upregulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1904488 GO:0086006 biolink:MolecularActivity voltage-gated sodium channel activity involved in cardiac muscle cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0086006 GO:0062046 biolink:MolecularActivity dehydropipecolic acid reductase Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+. go.json http://purl.obolibrary.org/obo/GO_0062046 GO:0086005 biolink:BiologicalProcess ventricular cardiac muscle cell action potential An action potential that occurs in a ventricular cardiac muscle cell. go.json http://purl.obolibrary.org/obo/GO_0086005 GO:1904487 biolink:BiologicalProcess obsolete cellular response to 17alpha-ethynylestradiol OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus. go.json True http://purl.obolibrary.org/obo/GO_1904487 GO:0062045 biolink:MolecularActivity L-lysine alpha-aminotransferase Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine. go.json http://purl.obolibrary.org/obo/GO_0062045 GO:1904497 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1904497 GO:0086004 biolink:BiologicalProcess regulation of cardiac muscle cell contraction Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. go.json http://purl.obolibrary.org/obo/GO_0086004 GO:0062048 biolink:CellularComponent lymphotoxin complex A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations. go.json lymphotoxin alpha-beta http://purl.obolibrary.org/obo/GO_0062048 GO:1904496 biolink:BiologicalProcess positive regulation of substance P secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission. go.json activation of substance P secretion, neurotransmission|up regulation of substance P secretion, neurotransmission|up-regulation of substance P secretion, neurotransmission|upregulation of substance P secretion, neurotransmission http://purl.obolibrary.org/obo/GO_1904496 GO:0086003 biolink:BiologicalProcess cardiac muscle cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. go.json http://purl.obolibrary.org/obo/GO_0086003 GO:0062047 biolink:MolecularActivity pipecolic acid N-hydroxylase Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O. go.json http://purl.obolibrary.org/obo/GO_0062047 GO:1904495 biolink:BiologicalProcess negative regulation of substance P secretion, neurotransmission Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission. go.json down regulation of substance P secretion, neurotransmission|down-regulation of substance P secretion, neurotransmission|downregulation of substance P secretion, neurotransmission|inhibition of substance P secretion, neurotransmission http://purl.obolibrary.org/obo/GO_1904495 GO:0086002 biolink:BiologicalProcess cardiac muscle cell action potential involved in contraction An action potential that occurs in a cardiac muscle cell and is involved in its contraction. go.json http://purl.obolibrary.org/obo/GO_0086002 GO:1904494 biolink:BiologicalProcess regulation of substance P secretion, neurotransmission Any process that modulates the frequency, rate or extent of substance P secretion, neurotransmission. go.json http://purl.obolibrary.org/obo/GO_1904494 GO:0086001 biolink:BiologicalProcess cardiac muscle cell action potential An action potential that occurs in a cardiac muscle cell. go.json http://purl.obolibrary.org/obo/GO_0086001 GO:0062049 biolink:CellularComponent protein phosphatase inhibitor complex A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase. go.json http://purl.obolibrary.org/obo/GO_0062049 GO:1904493 biolink:MolecularActivity tetrahydrofolyl-poly(glutamate) polymer binding Binding to tetrahydrofolyl-poly(glutamate) polymer. go.json http://purl.obolibrary.org/obo/GO_1904493 GO:1904492 biolink:MolecularActivity Ac-Asp-Glu binding Binding to Ac-Asp-Glu. go.json http://purl.obolibrary.org/obo/GO_1904492 GO:1904491 biolink:BiologicalProcess protein localization to ciliary transition zone A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. go.json protein localisation in ciliary transition zone|protein localisation to ciliary transition zone|protein localization in ciliary transition zone http://purl.obolibrary.org/obo/GO_1904491 GO:1904490 biolink:BiologicalProcess obsolete negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of mitochondrial unfolded protein response. go.json negative regulation of mitochondrial unfolded protein response by down regulation of global transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by down regulation of transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by down-regulation of global transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by down-regulation of transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by downregulation of global transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by downregulation of transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by inhibition of global transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by inhibition of transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of mitochondrial unfolded protein response by negative regulation of global transcription from Pol II promoter|negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from Pol II promoter|negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter, global|negative regulation of mtUPR by down regulation of global transcription from RNA polymerase II promoter|negative regulation of mtUPR by down regulation of transcription from RNA polymerase II promoter|negative regulation of mtUPR by down-regulation of global transcription from RNA polymerase II promoter|negative regulation of mtUPR by down-regulation of transcription from RNA polymerase II promoter|negative regulation of mtUPR by downregulation of global transcription from RNA polymerase II promoter|negative regulation of mtUPR by downregulation of transcription from RNA polymerase II promoter|negative regulation of mtUPR by inhibition of global transcription from RNA polymerase II promoter|negative regulation of mtUPR by inhibition of transcription from RNA polymerase II promoter|negative regulation of mtUPR by negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of mtUPR by negative regulation of global transcription from Pol II promoter|negative regulation of mtUPR by negative regulation of transcription from Pol II promoter|negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter|negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter, global True http://purl.obolibrary.org/obo/GO_1904490 GO:0062071 biolink:CellularComponent Pi Mi complex A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis. go.json http://purl.obolibrary.org/obo/GO_0062071 GO:0062070 biolink:MolecularActivity SAGA complex binding Binding to a SAGA complex. go.json http://purl.obolibrary.org/obo/GO_0062070 OIO:hasDbXref biolink:OntologyClass database_cross_reference go.json http://www.geneontology.org/formats/oboInOwl#hasDbXref GO:0062073 biolink:CellularComponent histone mRNA stem-loop binding complex A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export. go.json SLBP-MIF4GD complex|SLBP-SLIP1 complex http://purl.obolibrary.org/obo/GO_0062073 GO:0062072 biolink:MolecularActivity H3K9me3 modified histone binding Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation. go.json http://purl.obolibrary.org/obo/GO_0062072 GO:0062075 biolink:BiologicalProcess pollen aperture formation The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall. go.json http://purl.obolibrary.org/obo/GO_0062075 GO:0062074 biolink:CellularComponent pollen aperture An area where exine is reduced or absent, in the pollen wall. go.json http://purl.obolibrary.org/obo/GO_0062074 GO:0062077 biolink:CellularComponent phenylacetyl-CoA 1,2-epoxidase complex A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+. go.json paaABCE complex http://purl.obolibrary.org/obo/GO_0062077 GO:0062076 biolink:MolecularActivity acyl-CoA delta5-desaturase activity Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA). EC:1.14.19.44 go.json acyl-CoA (8-3)-desaturase|acyl-CoA D5-desaturase activity|acyl-CoA delta(5)-desaturase activity http://purl.obolibrary.org/obo/GO_0062076 GO:1904499 biolink:BiologicalProcess obsolete regulation of chromatin-mediated maintenance of transcription OBSOLETE. Any process that modulates the frequency, rate or extent of chromatin-mediated maintenance of transcription. go.json True http://purl.obolibrary.org/obo/GO_1904499 GO:0086039 biolink:MolecularActivity P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential. go.json calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential http://purl.obolibrary.org/obo/GO_0086039 GO:0062079 biolink:CellularComponent ATG2-ATG18 complex A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0062079 GO:0086038 biolink:MolecularActivity calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell. go.json http://purl.obolibrary.org/obo/GO_0086038 GO:1904498 biolink:BiologicalProcess protein localization to mitotic actomyosin contractile ring Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis. go.json protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis|protein localisation to actomyosin contractile ring involved in mitotic cytokinesis|protein localization to actomyosin contractile ring during mitotic cytokinesis|protein localization to actomyosin contractile ring involved in cytokinesis after mitosis|protein localization to actomyosin contractile ring involved in mitotic cytokinesis http://purl.obolibrary.org/obo/GO_1904498 GO:0062078 biolink:MolecularActivity TSC1-TSC2 complex binding Binding to a TSC1-TSC2 complex. go.json tuberin sclerosis complex binding|tuberin-hamartin complex binding http://purl.obolibrary.org/obo/GO_0062078 GO:0086037 biolink:MolecularActivity P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell. go.json http://purl.obolibrary.org/obo/GO_0086037 GO:0086036 biolink:BiologicalProcess regulation of cardiac muscle cell membrane potential Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json http://purl.obolibrary.org/obo/GO_0086036 GO:0086033 biolink:BiologicalProcess G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. go.json G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate|M2 receptor signalling pathway involved in negative regulation of heart rate|muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate|muscarinic receptor signalling pathway involved in negative regulation of heart rate http://purl.obolibrary.org/obo/GO_0086033 GO:0086030 biolink:BiologicalProcess adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation. go.json Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation|adrenergic receptor signaling pathway involved in cardiac muscle relaxation|adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC|adrenergic receptor-induced cardiac relaxation http://purl.obolibrary.org/obo/GO_0086030 GO:0062060 biolink:MolecularActivity NuA4 histone acetyltransferase complex binding Binding to a NuA4 histone acetyltransferase complex. go.json http://purl.obolibrary.org/obo/GO_0062060 GO:0062062 biolink:MolecularActivity oligosaccharyltransferase complex binding Binding to an oligosaccharyltransferase complex. go.json http://purl.obolibrary.org/obo/GO_0062062 GO:0062061 biolink:MolecularActivity TAP complex binding Binding to a TAP complex. go.json http://purl.obolibrary.org/obo/GO_0062061 GO:0062064 biolink:MolecularActivity box C/D snoRNP complex binding Binding to a box C/D snoRNP complex. go.json http://purl.obolibrary.org/obo/GO_0062064 GO:0062063 biolink:MolecularActivity BBSome binding Binding to a BBSome complex. go.json http://purl.obolibrary.org/obo/GO_0062063 GO:0062066 biolink:MolecularActivity PSII associated light-harvesting complex II binding Binding to a PSII associated light-harvesting complex II. go.json http://purl.obolibrary.org/obo/GO_0062066 GO:0062065 biolink:MolecularActivity box H/ACA snoRNP complex binding Binding to a box H/ACA snoRNP complex. go.json http://purl.obolibrary.org/obo/GO_0062065 GO:0086029 biolink:BiologicalProcess Purkinje myocyte to ventricular cardiac muscle cell signaling Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. go.json Purkinje myocyte to ventricular cardiac muscle cell signalling http://purl.obolibrary.org/obo/GO_0086029 GO:0062068 biolink:MolecularActivity chloroplast photosystem II binding Binding to a chloroplast photosystem II. go.json http://purl.obolibrary.org/obo/GO_0062068 GO:0086028 biolink:BiologicalProcess bundle of His cell to Purkinje myocyte signaling Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte. go.json bundle of His cardiac muscle cell to Purkinje myocyte signaling|bundle of His cardiac muscle cell to Purkinje myocyte signalling http://purl.obolibrary.org/obo/GO_0086028 GO:0086027 biolink:BiologicalProcess AV node cell to bundle of His cell signaling Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. go.json AV node cell to bundle of His cell signalling|atrioventricular node to bundle of His cell signaling http://purl.obolibrary.org/obo/GO_0086027 GO:0062067 biolink:MolecularActivity chloroplast photosystem I binding Binding to a chloroplast photosystem I. go.json http://purl.obolibrary.org/obo/GO_0062067 GO:0086026 biolink:BiologicalProcess atrial cardiac muscle cell to AV node cell signaling Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell. go.json atrial cardiomyocyte to AV node cell signaling|atrial cardiomyocyte to AV node cell signalling|atrial cardiomyocyte to atrioventricular node cell signaling http://purl.obolibrary.org/obo/GO_0086026 GO:0062069 biolink:MolecularActivity GARP complex binding Binding to a GARP complex. go.json http://purl.obolibrary.org/obo/GO_0062069 GO:0086024 biolink:BiologicalProcess adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate. go.json Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|If activation by beta-adrenergic receptor signaling pathway|activation of funny current by beta-adrenergic receptor signaling pathway|adenylate cyclase-activating cardiac adrenergic receptor signaling pathway|adrenergic receptor signaling pathway involved in positive regulation of heart rate|adrenergic receptor signalling pathway involved in positive regulation of heart rate|beta adrenergic receptor signaling pathway involved in positive regulation of heart rate http://purl.obolibrary.org/obo/GO_0086024 GO:0086023 biolink:BiologicalProcess adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process The series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart. go.json adrenergic receptor signaling pathway involved in heart process|adrenergic receptor signalling pathway involved in heart process|beta-adrenergic receptor signalling pathway involved in heart process http://purl.obolibrary.org/obo/GO_0086023 GO:0086022 biolink:BiologicalProcess SA node cell-atrial cardiac muscle cell adhesion involved in cell communication The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. go.json SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication|SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication|SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication|sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication|sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication http://purl.obolibrary.org/obo/GO_0086022 GO:0086021 biolink:BiologicalProcess SA node cell to atrial cardiac muscle cell communication by electrical coupling The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels. go.json SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling|SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling|SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling|sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling|sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling http://purl.obolibrary.org/obo/GO_0086021 GO:0086020 biolink:MolecularActivity gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. go.json gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling|gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling|gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling|gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling http://purl.obolibrary.org/obo/GO_0086020 GO:0052601 biolink:MolecularActivity (S)-limonene 1,2-monooxygenase activity Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide. EC:1.14.13.107|KEGG_REACTION:R09385|KEGG_REACTION:R09389|MetaCyc:RXN-9409 go.json (-)-limonene 1,2-monooxygenase activity|(-)-limonene,NAD(P)H:oxygen oxidoreductase activity|(S)-limonene,NAD(P)H:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052601 GO:0003678 biolink:MolecularActivity DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis. Reactome:R-HSA-5693589 go.json ATP-dependent DNA helicase activity http://purl.obolibrary.org/obo/GO_0003678 GO:0052600 biolink:MolecularActivity propane-1,3-diamine oxidase activity Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+. EC:1.4.3.22|KEGG_REACTION:R03139|MetaCyc:RXN-6381|RHEA:30895 go.json 1,3-diaminopropane oxidase activity|trimethylenediamine oxidase activity http://purl.obolibrary.org/obo/GO_0052600 GO:0003677 biolink:MolecularActivity DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). go.json microtubule/chromatin interaction|plasmid binding|structure specific DNA binding|structure-specific DNA binding http://purl.obolibrary.org/obo/GO_0003677 goslim_agr|goslim_candida|goslim_chembl|goslim_drosophila|goslim_flybase_ribbon|goslim_generic|goslim_mouse|goslim_plant|goslim_yeast|prokaryote_subset GO:0003679 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003679 GO:0003674 biolink:MolecularActivity molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. go.json molecular function http://purl.obolibrary.org/obo/GO_0003674 goslim_candida|goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant|goslim_yeast GO:0052605 biolink:MolecularActivity gamma-tocopherol cyclase activity Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol. KEGG_REACTION:R07502|MetaCyc:RXN-2543|RHEA:37983 go.json http://purl.obolibrary.org/obo/GO_0052605 GO:0052604 biolink:MolecularActivity delta-tocopherol cyclase activity Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol. KEGG_REACTION:R07503|MetaCyc:RXN-2561|RHEA:37987 go.json http://purl.obolibrary.org/obo/GO_0052604 GO:0003673 biolink:BiologicalProcess obsolete Gene_Ontology OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes. go.json Gene_Ontology True http://purl.obolibrary.org/obo/GO_0003673 GO:0052603 biolink:MolecularActivity 1-chloro-4-nitrosobenzene nitroreductase activity Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O. MetaCyc:RXN-8834|UM-BBD_enzymeID:e0245 go.json http://purl.obolibrary.org/obo/GO_0052603 GO:0003676 biolink:MolecularActivity nucleic acid binding Binding to a nucleic acid. go.json base pairing http://purl.obolibrary.org/obo/GO_0003676 goslim_chembl|goslim_metagenomics|goslim_pir|goslim_plant GO:0052602 biolink:MolecularActivity 4-chloronitrobenzene nitroreductase activity Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O. MetaCyc:RXN-8833|UM-BBD_enzymeID:e0245 go.json http://purl.obolibrary.org/obo/GO_0052602 GO:0003675 biolink:CellularComponent obsolete protein OBSOLETE. (Was not defined before being made obsolete). go.json protein True http://purl.obolibrary.org/obo/GO_0003675 GO:0052609 biolink:MolecularActivity 4-ketotorulene 3-hydroxylase activity Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O. MetaCyc:RXN-8218 go.json beta-carotene hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|carotene beta-ring hydroxylase activity http://purl.obolibrary.org/obo/GO_0052609 GO:0052608 biolink:MolecularActivity echinenone 3-hydroxylase activity Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O. MetaCyc:RXN-8214 go.json beta-carotene hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|carotene beta-ring hydroxylase activity http://purl.obolibrary.org/obo/GO_0052608 GO:0052607 biolink:MolecularActivity 7-hydroxy-chlorophyllide a oxygenase activity Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O. KEGG_REACTION:R08204|MetaCyc:RXN-7677|RHEA:22136 go.json 7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity|7-hydroxychlorophyllide-a oxygenase activity|CAO activity|chlorophyll b synthetase activity|chlorophyll-b synthase activity http://purl.obolibrary.org/obo/GO_0052607 GO:0052606 biolink:MolecularActivity chlorophyllide a oxygenase activity Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O. KEGG_REACTION:R08203|MetaCyc:RXN-7676|RHEA:22676 go.json CAO activity|chlorophyll a oxygenase activity|chlorophyllide a:oxygen 7-oxidoreductase activity|chlorophyllide-a oxygenase activity http://purl.obolibrary.org/obo/GO_0052606 GO:0003689 biolink:MolecularActivity DNA clamp loader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. Reactome:R-HSA-174439|Reactome:R-HSA-176264 go.json DNA clamp loading ATPase activity|DNA-protein loading ATPase activity|PCNA loading activity|PCNA loading complex activity|protein-DNA loading ATPase activity http://purl.obolibrary.org/obo/GO_0003689 GO:0052612 biolink:MolecularActivity adonirubin 3-hydroxylase activity Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O. MetaCyc:RXN-8187 go.json beta-carotene hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|carotene beta-ring hydroxylase activity http://purl.obolibrary.org/obo/GO_0052612 GO:0052611 biolink:MolecularActivity beta-carotene 3-hydroxylase activity Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O. MetaCyc:RXN-8025|RHEA:30323 go.json beta-carotene hydroxylase activity|carotene beta-ring hydroxylase activity http://purl.obolibrary.org/obo/GO_0052611 GO:0003688 biolink:MolecularActivity DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. go.json ARS binding http://purl.obolibrary.org/obo/GO_0003688 GO:0052610 biolink:MolecularActivity beta-cryptoxanthin hydroxylase activity Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O. MetaCyc:RXN-8026|RHEA:30327 go.json beta-carotene hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|carotene beta-ring hydroxylase activity http://purl.obolibrary.org/obo/GO_0052610 GO:0052616 biolink:MolecularActivity ent-kaur-16-en-19-ol oxidase activity Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al. EC:1.14.14.86|MetaCyc:RXN-5242|RHEA:21304 go.json http://purl.obolibrary.org/obo/GO_0052616 GO:0003685 biolink:MolecularActivity obsolete DNA repair protein OBSOLETE. (Was not defined before being made obsolete). go.json DNA repair protein True http://purl.obolibrary.org/obo/GO_0003685 GO:0052615 biolink:MolecularActivity ent-kaurene oxidase activity Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol. EC:1.14.14.86|MetaCyc:1.14.13.78-RXN|RHEA:32323 go.json http://purl.obolibrary.org/obo/GO_0052615 GO:0003684 biolink:MolecularActivity damaged DNA binding Binding to damaged DNA. go.json DNA repair enzyme|DNA repair protein http://purl.obolibrary.org/obo/GO_0003684 GO:0052614 biolink:MolecularActivity uracil oxygenase activity Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate. MetaCyc:RXN0-6444|RHEA:31587 go.json pyrimidine oxygenase activity http://purl.obolibrary.org/obo/GO_0052614 GO:0003687 biolink:MolecularActivity obsolete DNA replication factor OBSOLETE. (Was not defined before being made obsolete). go.json DNA replication factor True http://purl.obolibrary.org/obo/GO_0003687 GO:0052613 biolink:MolecularActivity canthaxanthin 3-hydroxylase activity Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O. MetaCyc:RXN-8186 go.json beta-carotene hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|carotene beta-ring hydroxylase activity http://purl.obolibrary.org/obo/GO_0052613 GO:0003686 biolink:MolecularActivity obsolete DNA repair enzyme OBSOLETE. (Was not defined before being made obsolete). go.json DNA repair enzyme True http://purl.obolibrary.org/obo/GO_0003686 GO:0003681 biolink:MolecularActivity bent DNA binding Binding to DNA in a bent conformation. go.json http://purl.obolibrary.org/obo/GO_0003681 GO:0003680 biolink:MolecularActivity minor groove of adenine-thymine-rich DNA binding Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins. go.json AT DNA binding|AT binding|AT-rich DNA binding http://purl.obolibrary.org/obo/GO_0003680 GO:0052619 biolink:MolecularActivity coenzyme F420-1:gamma-L-glutamate ligase activity Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate. EC:6.3.2.34|MetaCyc:RXN-8081|RHEA:30523 go.json http://purl.obolibrary.org/obo/GO_0052619 GO:0052618 biolink:MolecularActivity coenzyme F420-0:L-glutamate ligase activity Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate. EC:6.3.2.31|MetaCyc:RXN-8080|RHEA:30555 go.json http://purl.obolibrary.org/obo/GO_0052618 GO:0003683 biolink:MolecularActivity obsolete lamin/chromatin binding OBSOLETE. (Was not defined before being made obsolete). go.json lamin/chromatin binding True http://purl.obolibrary.org/obo/GO_0003683 GO:0003682 biolink:MolecularActivity chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. go.json lamin/chromatin binding|microtubule/chromatin interaction|nuclear membrane vesicle binding to chromatin http://purl.obolibrary.org/obo/GO_0003682 goslim_chembl|goslim_drosophila|goslim_pir|goslim_plant|goslim_yeast GO:0052617 biolink:MolecularActivity ent-kaur-16-en-19-al oxidase activity Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate. EC:1.14.14.86|MetaCyc:RXN-7580|RHEA:10928 go.json http://purl.obolibrary.org/obo/GO_0052617 GO:0052623 biolink:MolecularActivity ADP dimethylallyltransferase activity Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate. EC:2.5.1.-|KEGG_REACTION:R08051|MetaCyc:RXN-4305 go.json 2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity|2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity|ADP isopentenyltransferase activity|dimethylallyl-diphosphate:ADP dimethylallyltransferase activity http://purl.obolibrary.org/obo/GO_0052623 GO:0052622 biolink:MolecularActivity ATP dimethylallyltransferase activity Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate. EC:2.5.1.-|KEGG_REACTION:R08052|MetaCyc:RXN-4303 go.json 2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity|2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity|ATP isopentenyltransferase activity|dimethylallyl-diphosphate:ATP dimethylallyltransferase activity http://purl.obolibrary.org/obo/GO_0052622 GO:0052621 biolink:MolecularActivity diguanylate cyclase activity Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. EC:2.7.7.65|KEGG_REACTION:R08057|MetaCyc:RXN0-5359|RHEA:24898 go.json GTP:GTP guanylyltransferase activity http://purl.obolibrary.org/obo/GO_0052621 GO:0052620 biolink:MolecularActivity thymine dehydrogenase activity Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2. EC:1.17.99.4|MetaCyc:RXN-8646|RHEA:13469 go.json http://purl.obolibrary.org/obo/GO_0052620 GO:0052627 biolink:MolecularActivity vanillate amino acid synthetase activity Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate. go.json http://purl.obolibrary.org/obo/GO_0052627 GO:0052626 biolink:MolecularActivity benzoate amino acid synthetase activity Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate. go.json benzoyl amino acid synthetase activity http://purl.obolibrary.org/obo/GO_0052626 GO:0052625 biolink:MolecularActivity 4-aminobenzoate amino acid synthetase activity Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate. go.json 4-aminobenzoyl amino acid synthetase activity|p-aminobenzoate amino acid synthetase activity|p-aminobenzoyl amino acid synthetase activity|pABA amino acid synthetase activity http://purl.obolibrary.org/obo/GO_0052625 GO:0052624 biolink:MolecularActivity 2-phytyl-1,4-naphthoquinone methyltransferase activity Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+. KEGG_REACTION:R06859|MetaCyc:RXN-6723|MetaCyc:RXN-7569 go.json S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity|S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity|S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity|SA methyltransferase activity|demethylphylloquinone methyltransferase activity|salicylate methyltransferase activity|salicylic acid methyltransferase activity http://purl.obolibrary.org/obo/GO_0052624 GO:0052629 biolink:MolecularActivity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. EC:3.1.3.95|MetaCyc:RXN-10958|RHEA:39019|Reactome:R-HSA-1676065|Reactome:R-HSA-1676105|Reactome:R-HSA-1676203|Reactome:R-HSA-6809320|Reactome:R-HSA-6809778|Reactome:R-HSA-6809944 go.json http://purl.obolibrary.org/obo/GO_0052629 GO:0052628 biolink:MolecularActivity 4-hydroxybenzoate amino acid synthetase activity Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate. go.json 4-hydroxybenzoyl amino acid synthetase activity|4HBA amino acid synthetase activity|p-hydroxybenzoate amino acid synthetase activity|p-hydroxybenzoyl amino acid synthetase activity http://purl.obolibrary.org/obo/GO_0052628 GO:0052634 biolink:MolecularActivity C-19 gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons. EC:1.14.11.13 go.json (C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)|C(19) gibberellin 2-oxidase activity|C-19 GA 2-oxidase activity|C-19 gibberellin 2-beta-hydroxylase activity|C-19 gibberellin 2-oxidase activity|C-19 gibberellin 2beta-dioxygenase activity|C-19 gibberellin 2beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0052634 GO:0052633 biolink:MolecularActivity obsolete isocitrate hydro-lyase (cis-aconitate-forming) activity OBSOLETE. Catalysis of the reaction: cis-aconitate + H2O = isocitrate. go.json aconitate hydratase activity|cis-aconitase activity|citrate hydro-lyase activity|citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|citrate(isocitrate) hydro-lyase activity True http://purl.obolibrary.org/obo/GO_0052633 GO:0052632 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052632 GO:0052631 biolink:MolecularActivity sphingolipid delta-8 desaturase activity Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8). MetaCyc:RXN-7798|RHEA:46268 go.json http://purl.obolibrary.org/obo/GO_0052631 GO:0052638 biolink:MolecularActivity indole-3-butyrate beta-glucosyltransferase activity Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP. MetaCyc:RXN-11655|RHEA:62708 go.json IBA-Glc synthetase activity|IBA-glucose synthase activity|IBAGlu synthase activity|UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity|UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity|UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity|UDPG-indol-3-ylbutyryl glucosyl transferase activity|UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity|indol-3-ylbutyrylglucose synthase activity|indole-3-butyric acid glucosyltransferase activity|uridine diphosphoglucose-indolebutyrate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0052638 GO:0052637 biolink:MolecularActivity delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol. go.json http://purl.obolibrary.org/obo/GO_0052637 GO:0052636 biolink:MolecularActivity arabinosyltransferase activity Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor). go.json arabinosyl transferase activity http://purl.obolibrary.org/obo/GO_0052636 GO:0052635 biolink:MolecularActivity C-20 gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons. go.json (C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)|C(20) gibberellin 2-oxidase activity|C-20 GA 2-oxidase activity|C-20 gibberellin 2-beta-hydroxylase activity|C-20 gibberellin 2-oxidase activity|C-20 gibberellin 2beta-dioxygenase activity|C-20 gibberellin 2beta-hydroxylase activity http://purl.obolibrary.org/obo/GO_0052635 GO:0052639 biolink:MolecularActivity salicylic acid glucosyltransferase (ester-forming) activity Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP. MetaCyc:RXN-11659|RHEA:62316 go.json UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity|UDP:glucose:SA glucosyltransferase (ester-forming) activity|UDP:glucose:salicylate glucosyltransferase (ester-forming) activity|UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity|salicylic acid glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0052639 GO:0052630 biolink:MolecularActivity UDP-N-acetylgalactosamine diphosphorylase activity Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine. EC:2.7.7.83|RHEA:34363 go.json N-acetylgalactosamine 1-phosphate uridylyltransferase|N-acetylgalactosamine-1-phosphate uridyltransferase activity|UDP-GalNAc pyrophosphorylase activity|UDP-N-acetylgalactosamine pyrophosphorylase activity|UDP-acetylgalactosamine pyrophosphorylase activity|UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity|UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity|uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity|uridine diphosphoacetylgalactosamine phosphorylase activity|uridine diphosphoacetylgalactosamine pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0052630 GO:0052645 biolink:BiologicalProcess F420-0 metabolic process The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues. go.json F(420)-0 metabolic process|F420-0 metabolism|coenzyme F420-0 metabolic process|coenzyme F420-0 metabolism http://purl.obolibrary.org/obo/GO_0052645 GO:0052644 biolink:BiologicalProcess chlorophyllide a metabolic process The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a. go.json chlorophyllide a metabolism http://purl.obolibrary.org/obo/GO_0052644 GO:0052643 biolink:BiologicalProcess chlorophyllide metabolic process The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl. go.json chlorophyllide metabolism http://purl.obolibrary.org/obo/GO_0052643 GO:0052642 biolink:MolecularActivity lysophosphatidic acid phosphatase activity Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. Reactome:R-HSA-8878654 go.json LPA phosphatase activity|lysophosphatidate phosphatase activity http://purl.obolibrary.org/obo/GO_0052642 GO:0052649 biolink:BiologicalProcess coenzyme gamma-F420-2 metabolic process The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid. go.json F420-2 metabolic process|F420-2 metabolism|coenzyme F420 metabolic process|coenzyme F420 metabolism|coenzyme gamma-F420-2 metabolism http://purl.obolibrary.org/obo/GO_0052649 GO:0052648 biolink:BiologicalProcess ribitol phosphate metabolic process The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. go.json ribitol phosphate metabolism http://purl.obolibrary.org/obo/GO_0052648 GO:0052647 biolink:BiologicalProcess pentitol phosphate metabolic process The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule. go.json pentitol phosphate metabolism http://purl.obolibrary.org/obo/GO_0052647 GO:0052646 biolink:BiologicalProcess alditol phosphate metabolic process The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. go.json alditol phosphate metabolism http://purl.obolibrary.org/obo/GO_0052646 GO:0052641 biolink:MolecularActivity benzoic acid glucosyltransferase activity Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP. MetaCyc:RXN-11660 go.json UDP:glucose:BA glucosyltransferase activity|UDP:glucose:benzoate glucosyltransferase activity|UDP:glucose:benzoic acid glucosyltransferase activity|benzoate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0052641 GO:0052640 biolink:MolecularActivity salicylic acid glucosyltransferase (glucoside-forming) activity Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP. MetaCyc:RXN-11658|RHEA:62312 go.json UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity|UDP:glucose:SA glucosyltransferase (glucoside-forming) activity|UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity|UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity|salicylic acid glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0052640 GO:0052656 biolink:MolecularActivity L-isoleucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. EC:2.6.1.42|KEGG_REACTION:R02199|MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN|RHEA:24801 go.json L-isoleucine aminotransferase activity http://purl.obolibrary.org/obo/GO_0052656 goslim_chembl GO:0052655 biolink:MolecularActivity L-valine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid. EC:2.6.1.42|KEGG_REACTION:R01214|MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN|RHEA:24813 go.json L-valine aminotransferase activity http://purl.obolibrary.org/obo/GO_0052655 goslim_chembl GO:0052654 biolink:MolecularActivity L-leucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid. EC:2.6.1.42|KEGG_REACTION:R01090|MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN go.json L-leucine aminotransferase activity http://purl.obolibrary.org/obo/GO_0052654 goslim_chembl GO:0052653 biolink:BiologicalProcess 3',5'-cyclic diguanylic acid metabolic process The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine. go.json 3',5'-cyclic diguanylic acid metabolism|cdiGMP metabolic process|cdiGMP metabolism|cyclic diguanylate metabolic process|cyclic diguanylate metabolism http://purl.obolibrary.org/obo/GO_0052653 GO:1904409 biolink:BiologicalProcess regulation of secretory granule organization Any process that modulates the frequency, rate or extent of secretory granule organization. go.json regulation of secretory granule organisation|regulation of secretory granule organization and biogenesis http://purl.obolibrary.org/obo/GO_1904409 GO:0052659 biolink:MolecularActivity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. EC:3.1.3.56|KEGG_REACTION:R03430|MetaCyc:RXN-8730|RHEA:11392|Reactome:R-HSA-1855213|Reactome:R-HSA-1855218 go.json 5PTase activity|D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity|Ins(1,3,4,5)P(4) 5-phosphatase activity|Ins(1,3,4,5)P4 5-phosphatase activity|inositol polyphosphate-5-phosphatase activity|type I inositol-polyphosphate phosphatase activity|type II inositol polyphosphate 5-phosphatase activity http://purl.obolibrary.org/obo/GO_0052659 GO:0052658 biolink:MolecularActivity inositol-1,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. EC:3.1.3.56|KEGG_REACTION:R03394|MetaCyc:3.1.3.56-RXN|RHEA:19797|Reactome:R-HSA-1855174|Reactome:R-HSA-1855222 go.json 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity|5PTase activity|D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity|D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity|D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity|Ins(1,4,5)P3 5-phosphatase activity|InsP(3) 5-phosphatase activity|InsP3 5-phosphatase activity|L-myo-inositol 1,4,5-trisphosphate-monoesterase activity|inosine triphosphatase activity|inositol 1,4,5-trisphosphate phosphatase activity|inositol phosphate 5-phosphomonoesterase activity|inositol polyphosphate-5-phosphatase activity|inositol triphosphate 5-phosphomonoesterase activity|inositol trisphosphate phosphomonoesterase activity|myo-inositol-1,4,5-trisphosphate 5-phosphatase activity|type I inositol-polyphosphate phosphatase activity|type II inositol polyphosphate 5-phosphatase activity http://purl.obolibrary.org/obo/GO_0052658 GO:1904408 biolink:MolecularActivity melatonin binding Binding to melatonin. go.json http://purl.obolibrary.org/obo/GO_1904408 GO:1904407 biolink:BiologicalProcess positive regulation of nitric oxide metabolic process Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process. go.json activation of nitric oxide metabolic process|activation of nitric oxide metabolism|positive regulation of nitric oxide metabolism|up regulation of nitric oxide metabolic process|up regulation of nitric oxide metabolism|up-regulation of nitric oxide metabolic process|up-regulation of nitric oxide metabolism|upregulation of nitric oxide metabolic process|upregulation of nitric oxide metabolism http://purl.obolibrary.org/obo/GO_1904407 GO:0052657 biolink:MolecularActivity guanine phosphoribosyltransferase activity Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. EC:2.4.2.8|KEGG_REACTION:R01229|MetaCyc:GUANPRIBOSYLTRAN-RXN|RHEA:25424 go.json 6-hydroxypurine phosphoribosyltransferase activity|6-mercaptopurine phosphoribosyltransferase activity|GMP pyrophosphorylase activity|GPRT|Transphosphoribosidase activity|guanine-hypoxanthine phosphoribosyltransferase activity|guanosine 5'-phosphate pyrophosphorylase activity|guanosine phosphoribosyltransferase activity|guanylate pyrophosphorylase activity|guanylic pyrophosphorylase activity|hypoxanthine-guanine phosphoribosyltransferase activity|purine-6-thiol phosphoribosyltransferase activity http://purl.obolibrary.org/obo/GO_0052657 GO:1904406 biolink:BiologicalProcess negative regulation of nitric oxide metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. go.json down regulation of nitric oxide metabolic process|down regulation of nitric oxide metabolism|down-regulation of nitric oxide metabolic process|down-regulation of nitric oxide metabolism|downregulation of nitric oxide metabolic process|downregulation of nitric oxide metabolism|inhibition of nitric oxide metabolic process|inhibition of nitric oxide metabolism|negative regulation of nitric oxide metabolism http://purl.obolibrary.org/obo/GO_1904406 GO:1904405 biolink:BiologicalProcess cellular response to formaldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_1904405 GO:1904404 biolink:BiologicalProcess response to formaldehyde Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus. go.json http://purl.obolibrary.org/obo/GO_1904404 GO:1904403 biolink:BiologicalProcess cellular response to nocodazole Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus. go.json http://purl.obolibrary.org/obo/GO_1904403 GO:1904402 biolink:BiologicalProcess response to nocodazole Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus. go.json http://purl.obolibrary.org/obo/GO_1904402 GO:1904401 biolink:BiologicalProcess cellular response to Thyroid stimulating hormone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_1904401 GO:1904400 biolink:BiologicalProcess response to Thyroid stimulating hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_1904400 GO:0052652 biolink:BiologicalProcess cyclic purine nucleotide metabolic process The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine. go.json cyclic purine nucleotide metabolism http://purl.obolibrary.org/obo/GO_0052652 GO:0052651 biolink:BiologicalProcess monoacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. go.json monoacylglycerol breakdown|monoacylglycerol catabolism|monoacylglycerol degradation http://purl.obolibrary.org/obo/GO_0052651 GO:0052650 biolink:MolecularActivity NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. EC:1.1.1.300|KEGG_REACTION:R08379|MetaCyc:RXN-10841|RHEA:25033|Reactome:R-HSA-2464803|Reactome:R-HSA-2464822|Reactome:R-HSA-2465921|Reactome:R-HSA-2465940|Reactome:R-HSA-2466861|Reactome:R-HSA-2471670|Reactome:R-HSA-5419165|Reactome:R-HSA-5615668|Reactome:R-HSA-5623643|Reactome:R-HSA-74872 go.json NADP(H)-dependent retinol dehydrogenase/reductase activity|all-trans retinal reductase activity|all-trans-retinol dehydrogenase activity|retinol dehydrogenase [NADP+] activity|retinol dehydrogenase activity|retinol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052650 GO:0052667 biolink:MolecularActivity phosphomethylethanolamine N-methyltransferase activity Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H+. EC:2.1.1.103|KEGG_REACTION:R06868|MetaCyc:RXN-5642|RHEA:25321 go.json N-methylethanolamine phosphate N-methyltransferase activity|S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0052667 GO:0052666 biolink:MolecularActivity obsolete tRNA (cytosine-2'-O-)-methyltransferase activity OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine. Reactome:R-HSA-6788668|Reactome:R-HSA-6788684|Reactome:R-HSA-9024159 go.json S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity|tRNA (cytosine 2')-methyltransferase activity|tRNA cytosine 2'-methyltransferase activity|tRNA cytosine-2'-O-methyltransferase activity|transfer ribonucleate cytosine 2'-methyltransferase activity True http://purl.obolibrary.org/obo/GO_0052666 GO:0052665 biolink:MolecularActivity tRNA (uracil-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil. MetaCyc:RXN0-5143|Reactome:R-HSA-6788707 go.json tRNA (uracil 2')-methyltransferase activity|tRNA uracil 2'-methyltransferase activity|tRNA uracil-2'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0052665 GO:0052664 biolink:MolecularActivity nitroalkane oxidase activity Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2. EC:1.7.3.1|KEGG_REACTION:R00799|MetaCyc:RXN-11045 go.json NAO activity|nitroalkane reductase activity|nitroalkane:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052664 GO:1904419 biolink:BiologicalProcess negative regulation of telomeric loop formation Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop formation. go.json down regulation of t-loop biosynthesis|down regulation of t-loop formation|down regulation of telomeric loop formation|down-regulation of t-loop biosynthesis|down-regulation of t-loop formation|down-regulation of telomeric loop formation|downregulation of t-loop biosynthesis|downregulation of t-loop formation|downregulation of telomeric loop formation|inhibition of t-loop biosynthesis|inhibition of t-loop formation|inhibition of telomeric loop formation|negative regulation of t-loop biosynthesis|negative regulation of t-loop formation http://purl.obolibrary.org/obo/GO_1904419 GO:0052669 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052669 GO:1904418 biolink:BiologicalProcess regulation of telomeric loop formation Any process that modulates the frequency, rate or extent of telomeric loop formation. go.json regulation of t-loop biosynthesis|regulation of t-loop formation http://purl.obolibrary.org/obo/GO_1904418 GO:0052668 biolink:MolecularActivity CTP:farnesol kinase activity Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+. EC:2.7.1.216|MetaCyc:RXN-11625|RHEA:51680 go.json CTP:2-trans,-6-trans-farnesol kinase activity|CTP:2-trans,-6-trans-farnesol phosphotransferase activity|farnesol kinase activity|farnesol phosphotransferase activity|trans,trans-farnesol kinase activity http://purl.obolibrary.org/obo/GO_0052668 GO:1904417 biolink:BiologicalProcess positive regulation of xenophagy Any process that activates or increases the frequency, rate or extent of xenophagy. go.json activation of xenophagy|up regulation of xenophagy|up-regulation of xenophagy|upregulation of xenophagy http://purl.obolibrary.org/obo/GO_1904417 GO:1904416 biolink:BiologicalProcess negative regulation of xenophagy Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy. go.json down regulation of xenophagy|down-regulation of xenophagy|downregulation of xenophagy|inhibition of xenophagy http://purl.obolibrary.org/obo/GO_1904416 GO:1904415 biolink:BiologicalProcess regulation of xenophagy Any process that modulates the frequency, rate or extent of xenophagy. go.json http://purl.obolibrary.org/obo/GO_1904415 GO:1904414 biolink:BiologicalProcess positive regulation of cardiac ventricle development Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. go.json activation of cardiac ventricle development|up regulation of cardiac ventricle development|up-regulation of cardiac ventricle development|upregulation of cardiac ventricle development http://purl.obolibrary.org/obo/GO_1904414 GO:1904413 biolink:BiologicalProcess negative regulation of cardiac ventricle development Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. go.json down regulation of cardiac ventricle development|down-regulation of cardiac ventricle development|downregulation of cardiac ventricle development|inhibition of cardiac ventricle development http://purl.obolibrary.org/obo/GO_1904413 GO:1904412 biolink:BiologicalProcess regulation of cardiac ventricle development Any process that modulates the frequency, rate or extent of cardiac ventricle development. go.json http://purl.obolibrary.org/obo/GO_1904412 GO:1904411 biolink:BiologicalProcess positive regulation of secretory granule organization Any process that activates or increases the frequency, rate or extent of secretory granule organization. go.json activation of secretory granule organisation|activation of secretory granule organization|activation of secretory granule organization and biogenesis|positive regulation of secretory granule organisation|positive regulation of secretory granule organization and biogenesis|up regulation of secretory granule organisation|up regulation of secretory granule organization|up regulation of secretory granule organization and biogenesis|up-regulation of secretory granule organisation|up-regulation of secretory granule organization|up-regulation of secretory granule organization and biogenesis|upregulation of secretory granule organisation|upregulation of secretory granule organization|upregulation of secretory granule organization and biogenesis http://purl.obolibrary.org/obo/GO_1904411 GO:1904410 biolink:BiologicalProcess negative regulation of secretory granule organization Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. go.json down regulation of secretory granule organisation|down regulation of secretory granule organization|down regulation of secretory granule organization and biogenesis|down-regulation of secretory granule organisation|down-regulation of secretory granule organization|down-regulation of secretory granule organization and biogenesis|downregulation of secretory granule organisation|downregulation of secretory granule organization|downregulation of secretory granule organization and biogenesis|inhibition of secretory granule organisation|inhibition of secretory granule organization|inhibition of secretory granule organization and biogenesis|negative regulation of secretory granule organisation|negative regulation of secretory granule organization and biogenesis http://purl.obolibrary.org/obo/GO_1904410 GO:1904420 biolink:BiologicalProcess positive regulation of telomeric loop formation Any process that activates or increases the frequency, rate or extent of telomeric loop formation. go.json activation of t-loop biosynthesis|activation of t-loop formation|activation of telomeric loop formation|positive regulation of t-loop biosynthesis|positive regulation of t-loop formation|up regulation of t-loop biosynthesis|up regulation of t-loop formation|up regulation of telomeric loop formation|up-regulation of t-loop biosynthesis|up-regulation of t-loop formation|up-regulation of telomeric loop formation|upregulation of t-loop biosynthesis|upregulation of t-loop formation|upregulation of telomeric loop formation http://purl.obolibrary.org/obo/GO_1904420 GO:0052663 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0052663 GO:0052662 biolink:MolecularActivity zeaxanthin epoxidase activity Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]. EC:1.14.15.21|KEGG_REACTION:R06946|KEGG_REACTION:R06947|KEGG_REACTION:R07199|KEGG_REACTION:R07200|MetaCyc:RXN-7978|MetaCyc:RXN-7979|RHEA:24084 go.json antheraxanthin epoxidase activity|zea-epoxidase activity|zeaxanthin epoxidase [overall] activity http://purl.obolibrary.org/obo/GO_0052662 GO:0052661 biolink:MolecularActivity S-lactaldehyde reductase activity Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+. KEGG_REACTION:R02258|MetaCyc:LACTALDREDUCT-RXN|RHEA:15933 go.json (S)-propane-1,2-diol:NAD+ oxidoreductase activity|L-lactaldehyde:propanediol oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052661 GO:0052660 biolink:MolecularActivity R-lactaldehyde reductase activity Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+. KEGG_REACTION:R03080|MetaCyc:RXN-8641|RHEA:23872 go.json (R)-propane-1,2-diol:NAD+ oxidoreductase activity|D-lactaldehyde:propanediol oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052660 GO:0052678 biolink:MolecularActivity levopimaradiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate. EC:4.2.3.32|KEGG_REACTION:R06302|MetaCyc:RXN-8511|RHEA:25548 go.json ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity http://purl.obolibrary.org/obo/GO_0052678 GO:0052677 biolink:MolecularActivity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+. KEGG_REACTION:R07143|MetaCyc:RXN-7971|RHEA:21276 go.json ARD1p|D-arabinitol dehydrogenase 1 activity|D-arabinitol:NADP+ dehydrogenase activity|NADP+-dependent D-arabinitol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052677 GO:0052676 biolink:MolecularActivity 3-methylbutanol:NAD oxidoreductase activity Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde. KEGG_REACTION:R05685|RHEA:18529 go.json 3-methylbutanal reductase (NAD) activity|3-methylbutanol:NAD+ oxidoreductase activity|3-methylbutyraldehyde reductase (NAD) activity|isoamyl alcohol oxidase (NAD) activity http://purl.obolibrary.org/obo/GO_0052676 GO:0052675 biolink:MolecularActivity 3-methylbutanol:NADP oxidoreductase activity Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde. KEGG_REACTION:R05686|RHEA:18525 go.json 3-methylbutanal reductase (NADP) activity|3-methylbutanol:NADP+ oxidoreductase activity|3-methylbutyraldehyde reductase (NADP) activity|isoamyl alcohol oxidase (NADP) activity http://purl.obolibrary.org/obo/GO_0052675 GO:1904429 biolink:BiologicalProcess regulation of t-circle formation Any process that modulates the frequency, rate or extent of t-circle formation. go.json regulation of telomeric circle formation http://purl.obolibrary.org/obo/GO_1904429 GO:0052679 biolink:MolecularActivity terpentetriene synthase activity Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene. EC:4.2.3.36|MetaCyc:RXN-9455|RHEA:25617 go.json terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity http://purl.obolibrary.org/obo/GO_0052679 GO:1904428 biolink:BiologicalProcess negative regulation of tubulin deacetylation Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation. go.json down regulation of tubulin deacetylation|down-regulation of tubulin deacetylation|downregulation of tubulin deacetylation|inhibition of tubulin deacetylation http://purl.obolibrary.org/obo/GO_1904428 GO:1904427 biolink:BiologicalProcess positive regulation of calcium ion transmembrane transport Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. go.json activation of calcium ion membrane transport|activation of calcium ion transmembrane transport|activation of transmembrane calcium transport|positive regulation of calcium ion membrane transport|positive regulation of transmembrane calcium transport|up regulation of calcium ion membrane transport|up regulation of calcium ion transmembrane transport|up regulation of transmembrane calcium transport|up-regulation of calcium ion membrane transport|up-regulation of calcium ion transmembrane transport|up-regulation of transmembrane calcium transport|upregulation of calcium ion membrane transport|upregulation of calcium ion transmembrane transport|upregulation of transmembrane calcium transport http://purl.obolibrary.org/obo/GO_1904427 GO:1904426 biolink:BiologicalProcess positive regulation of GTP binding Any process that activates or increases the frequency, rate or extent of GTP binding. go.json activation of GTP binding|up regulation of GTP binding|up-regulation of GTP binding|upregulation of GTP binding http://purl.obolibrary.org/obo/GO_1904426 gocheck_do_not_annotate GO:1904425 biolink:BiologicalProcess negative regulation of GTP binding Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding. go.json down regulation of GTP binding|down-regulation of GTP binding|downregulation of GTP binding|inhibition of GTP binding http://purl.obolibrary.org/obo/GO_1904425 gocheck_do_not_annotate GO:1904424 biolink:BiologicalProcess regulation of GTP binding Any process that modulates the frequency, rate or extent of GTP binding. go.json http://purl.obolibrary.org/obo/GO_1904424 gocheck_do_not_annotate GO:1904423 biolink:CellularComponent dehydrodolichyl diphosphate synthase complex A protein complex which is capable of dehydrodolichyl diphosphate synthase activity. go.json http://purl.obolibrary.org/obo/GO_1904423 GO:1904422 biolink:BiologicalProcess cellular response to D-galactosamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904422 GO:1904421 biolink:BiologicalProcess response to D-galactosamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904421 GO:1904431 biolink:BiologicalProcess positive regulation of t-circle formation Any process that activates or increases the frequency, rate or extent of t-circle formation. go.json activation of t-circle formation|activation of telomeric circle formation|positive regulation of telomeric circle formation|up regulation of t-circle formation|up regulation of telomeric circle formation|up-regulation of t-circle formation|up-regulation of telomeric circle formation|upregulation of t-circle formation|upregulation of telomeric circle formation http://purl.obolibrary.org/obo/GO_1904431 GO:1904430 biolink:BiologicalProcess negative regulation of t-circle formation Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation. go.json down regulation of t-circle formation|down regulation of telomeric circle formation|down-regulation of t-circle formation|down-regulation of telomeric circle formation|downregulation of t-circle formation|downregulation of telomeric circle formation|inhibition of t-circle formation|inhibition of telomeric circle formation|negative regulation of telomeric circle formation http://purl.obolibrary.org/obo/GO_1904430 GO:0052670 biolink:MolecularActivity geraniol kinase activity Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate. go.json geraniol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0052670 GO:0052674 biolink:MolecularActivity ent-pimara-9(11),15-diene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate. EC:4.2.3.31|MetaCyc:RXN-9299|RHEA:25544 go.json PMD synthase activity|ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity http://purl.obolibrary.org/obo/GO_0052674 GO:0052673 biolink:MolecularActivity prenol kinase activity Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity. go.json prenol phosphotransferase activity|prenyl alcohol kinase activity|prenyl alcohol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0052673 GO:0052672 biolink:MolecularActivity CTP:geranylgeraniol kinase activity Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP. EC:2.7.1.216|MetaCyc:RXN-11629 go.json CTP:geranylgeraniol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0052672 GO:0052671 biolink:MolecularActivity geranylgeraniol kinase activity Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate. go.json geranylgeraniol phosphotransferase activity http://purl.obolibrary.org/obo/GO_0052671 GO:0003699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003699 GO:0003696 biolink:MolecularActivity satellite DNA binding Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. go.json http://purl.obolibrary.org/obo/GO_0003696 GO:0003695 biolink:MolecularActivity obsolete random coil DNA binding OBSOLETE. Binding to DNA in a random coil configuration. go.json random coil binding True http://purl.obolibrary.org/obo/GO_0003695 GO:0003698 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003698 GO:0003697 biolink:MolecularActivity single-stranded DNA binding Binding to single-stranded DNA. go.json ssDNA binding http://purl.obolibrary.org/obo/GO_0003697 GO:0003692 biolink:MolecularActivity left-handed Z-DNA binding Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. go.json http://purl.obolibrary.org/obo/GO_0003692 GO:0003691 biolink:MolecularActivity double-stranded telomeric DNA binding Binding to double-stranded telomere-associated DNA. go.json http://purl.obolibrary.org/obo/GO_0003691 GO:0003694 biolink:MolecularActivity obsolete plasmid binding OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms. go.json plasmid binding|plasmid-associated protein True http://purl.obolibrary.org/obo/GO_0003694 GO:0003693 biolink:MolecularActivity P-element binding Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis. go.json http://purl.obolibrary.org/obo/GO_0003693 GO:0003690 biolink:MolecularActivity double-stranded DNA binding Binding to double-stranded DNA. go.json dsDNA binding http://purl.obolibrary.org/obo/GO_0003690 GO:1904399 biolink:MolecularActivity heparan sulfate binding Binding to heparan sulfate. go.json http://purl.obolibrary.org/obo/GO_1904399 GO:0003832 biolink:MolecularActivity beta-alanyl-dopamine hydrolase activity Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine. go.json N-beta-alanyl-dopamine hydrolase activity|NBAD hydrolase activity http://purl.obolibrary.org/obo/GO_0003832 GO:0003831 biolink:MolecularActivity beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. EC:2.4.1.38|MetaCyc:2.4.1.38-RXN|RHEA:22932|Reactome:R-HSA-1912352|Reactome:R-HSA-2025723|Reactome:R-HSA-2046265|Reactome:R-HSA-2046298|Reactome:R-HSA-3656230|Reactome:R-HSA-4793956|Reactome:R-HSA-9035949|Reactome:R-HSA-9035950|Reactome:R-HSA-975919 go.json GalT activity|UDP-galactose--glycoprotein galactosyltransferase activity|UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity|UDPgalactose-glycoprotein galactosyltransferase activity|UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-N-acetyl-beta-(1,4)-galactosyltransferase activity|beta-N-acetyl-beta-1,4-galactosyltransferase activity|glycoprotein 4-beta-galactosyl-transferase activity|glycoprotein 4-beta-galactosyltransferase activity|glycoprotein beta-galactosyltransferase activity|thyroid galactosyltransferase activity|thyroid glycoprotein beta-galactosyltransferase|uridine diphosphogalactose-glycoprotein galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0003831 GO:0003834 biolink:MolecularActivity beta-carotene 15,15'-dioxygenase activity Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal. EC:1.13.11.63|KEGG_REACTION:R00032|MetaCyc:RXN-13374|RHEA:32887|Reactome:R-HSA-975635 go.json beta-carotene 15,15'-monooxygenase activity|carotene 15,15'-dioxygenase activity|carotene dioxygenase activity http://purl.obolibrary.org/obo/GO_0003834 GO:0003833 biolink:MolecularActivity beta-alanyl amine synthase activity Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine. go.json N-beta-alanyl dopamine synthetase activity|NBAD transferase activity|beta-alanyl-dopamine synthase activity http://purl.obolibrary.org/obo/GO_0003833 GO:0003830 biolink:MolecularActivity beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. EC:2.4.1.144|MetaCyc:2.4.1.144-RXN|RHEA:15509|Reactome:R-HSA-975926 go.json GnTIII activity|N-acetylglucosaminyltransferase III activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity|UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity|uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III http://purl.obolibrary.org/obo/GO_0003830 GO:1904319 biolink:BiologicalProcess negative regulation of smooth muscle contraction involved in micturition Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition. go.json down regulation of smooth muscle contraction involved in micturition|down regulation of smooth muscle contraction involved in urination|down regulation of urinary bladder smooth muscle contraction involved in micturition|down-regulation of smooth muscle contraction involved in micturition|down-regulation of smooth muscle contraction involved in urination|down-regulation of urinary bladder smooth muscle contraction involved in micturition|downregulation of smooth muscle contraction involved in micturition|downregulation of smooth muscle contraction involved in urination|downregulation of urinary bladder smooth muscle contraction involved in micturition|inhibition of smooth muscle contraction involved in micturition|inhibition of smooth muscle contraction involved in urination|inhibition of urinary bladder smooth muscle contraction involved in micturition|negative regulation of smooth muscle contraction involved in urination|negative regulation of urinary bladder smooth muscle contraction involved in micturition http://purl.obolibrary.org/obo/GO_1904319 GO:1904318 biolink:BiologicalProcess regulation of smooth muscle contraction involved in micturition Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. go.json regulation of smooth muscle contraction involved in urination|regulation of urinary bladder smooth muscle contraction involved in micturition http://purl.obolibrary.org/obo/GO_1904318 GO:1904317 biolink:BiologicalProcess cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus. go.json cellular response to PAF|cellular response to platelet-activating factor http://purl.obolibrary.org/obo/GO_1904317 GO:1904316 biolink:BiologicalProcess response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus. go.json response to PAF|response to platelet-activating factor http://purl.obolibrary.org/obo/GO_1904316 GO:0062130 biolink:CellularComponent adhesive extracellular matrix A extracellular matrix which attaches an organism to a substrate. go.json puparial glue http://purl.obolibrary.org/obo/GO_0062130 GO:1904315 biolink:MolecularActivity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. go.json ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential|ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_1904315 goslim_synapse GO:1904314 biolink:BiologicalProcess cellular response to methamphetamine hydrochloride Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus. go.json cellular response to methamphetamine HCL http://purl.obolibrary.org/obo/GO_1904314 GO:0062132 biolink:BiologicalProcess regulation of L-glutamine biosynthetic process Any process that modulates the rate, frequency or extent of L-glutamine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0062132 GO:1904313 biolink:BiologicalProcess response to methamphetamine hydrochloride Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus. go.json response to methamphetamine HCL http://purl.obolibrary.org/obo/GO_1904313 GO:0062131 biolink:MolecularActivity 3-butenylglucosinolate 2-hydroxylase activity Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O. MetaCyc:RXNQT-4343|RHEA:60628 go.json But-3-enyl Glucosinolate-2-hydroxylase activity http://purl.obolibrary.org/obo/GO_0062131 GO:0062134 biolink:BiologicalProcess positive regulation of L-glutamine biosynthetic process Any process that starts, increases the frequency, rate or extent of L-glutamine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0062134 GO:1904312 biolink:BiologicalProcess cellular response to gold(3+) Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus. go.json http://purl.obolibrary.org/obo/GO_1904312 GO:1904311 biolink:BiologicalProcess response to gold(3+) Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus. go.json http://purl.obolibrary.org/obo/GO_1904311 GO:0062133 biolink:BiologicalProcess negative regulation of L-glutamine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0062133 GO:1904321 biolink:BiologicalProcess response to forskolin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904321 GO:0062136 biolink:CellularComponent low-density lipoprotein receptor complex A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors. go.json LDL receptor complex|LDLR complex|low-density lipoprotein particle receptor complex http://purl.obolibrary.org/obo/GO_0062136 GO:1904320 biolink:BiologicalProcess positive regulation of smooth muscle contraction involved in micturition Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition. go.json activation of smooth muscle contraction involved in micturition|activation of smooth muscle contraction involved in urination|activation of urinary bladder smooth muscle contraction involved in micturition|positive regulation of smooth muscle contraction involved in urination|positive regulation of urinary bladder smooth muscle contraction involved in micturition|up regulation of smooth muscle contraction involved in micturition|up regulation of smooth muscle contraction involved in urination|up regulation of urinary bladder smooth muscle contraction involved in micturition|up-regulation of smooth muscle contraction involved in micturition|up-regulation of smooth muscle contraction involved in urination|up-regulation of urinary bladder smooth muscle contraction involved in micturition|upregulation of smooth muscle contraction involved in micturition|upregulation of smooth muscle contraction involved in urination|upregulation of urinary bladder smooth muscle contraction involved in micturition http://purl.obolibrary.org/obo/GO_1904320 GO:0062137 biolink:CellularComponent cargo receptor complex Any protein complex that is part of a membrane and which functions as a cargo receptor. go.json http://purl.obolibrary.org/obo/GO_0062137 GO:0062139 biolink:BiologicalProcess camera-type eye photoreceptor cell development The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0062139 GO:0003839 biolink:MolecularActivity gamma-glutamylcyclotransferase activity Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. EC:4.3.2.9|MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN|RHEA:20505|Reactome:R-HSA-1247922|Reactome:R-HSA-6785928 go.json (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)|L-glutamic cyclase activity|gamma-L-glutamylcyclotransferase activity|gamma-glutamyl-amino acid cyclotransferase activity http://purl.obolibrary.org/obo/GO_0003839 GO:0003836 biolink:MolecularActivity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. EC:2.4.3.4|MetaCyc:2.4.99.4-RXN|RHEA:21616|Reactome:R-HSA-1022129|Reactome:R-HSA-1912378|Reactome:R-HSA-2046285|Reactome:R-HSA-3656258|Reactome:R-HSA-4084984|Reactome:R-HSA-9603987|Reactome:R-HSA-9605600|Reactome:R-HSA-981497 go.json http://purl.obolibrary.org/obo/GO_0003836 GO:0003835 biolink:MolecularActivity beta-galactoside alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+. EC:2.4.3.1|MetaCyc:RXN-18268|Reactome:R-HSA-4085033|Reactome:R-HSA-975902|Reactome:R-HSA-977071 go.json CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity|beta-galactosamide alpha-2,6-sialyltransferase activity|beta-galactoside alpha-(2,6)-sialyltransferase|lactosylceramide alpha-2,6-N-sialyltransferase http://purl.obolibrary.org/obo/GO_0003835 GO:0003838 biolink:MolecularActivity sterol 24-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + zymosterol = fecosterol + H+ + S-adenosyl-L-homocysteine. EC:2.1.1.41|MetaCyc:RXN3O-178|RHEA:21128 go.json 24-sterol C-methyltransferase activity|S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity|S-adenosyl-4-methionine:sterol delta24-methyltransferase activity|S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity|S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity|S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity|SMT1 activity|delta(24)-methyltransferase activity|delta(24)-sterol C-methyltransferase activity|delta(24)-sterol methyltransferase activity|delta24-methyltransferase activity|delta24-sterol methyltransferase activity|phytosterol methyltransferase activity|sterol 24C methyltransferase activity|zymosterol-24-methyltransferase activity http://purl.obolibrary.org/obo/GO_0003838 GO:0003837 biolink:MolecularActivity beta-ureidopropionase activity Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. EC:3.5.1.6|MetaCyc:BETA-UREIDOPROPIONASE-RXN|RHEA:11184|Reactome:R-HSA-73591|Reactome:R-HSA-73620 go.json N-carbamoyl-beta-alanine amidohydrolase activity http://purl.obolibrary.org/obo/GO_0003837 GO:0003843 biolink:MolecularActivity 1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1). EC:2.4.1.34|MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN|RHEA:21476 go.json (1,3)-beta-glucan (callose) synthase activity|1,3-beta-D-glucan synthetase activity|1,3-beta-D-glucan-UDP glucosyltransferase activity|1,3-beta-glucan synthase activity|1,3-beta-glucan-uridine diphosphoglucosyltransferase activity|GS-II|UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity|UDP-glucose-1,3-beta-glucan glucosyltransferase activity|UDP-glucose-beta-glucan glucosyltransferase activity|UDP-glucose:(1,3)beta-glucan synthase activity|UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity|UDPglucose-1,3-beta-D-glucan glucosyltransferase activity|UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity|beta-1,3-glucan synthase activity|beta-1,3-glucan synthetase activity|callose synthase activity|callose synthetase activity|paramylon synthetase|uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0003843 GO:0003842 biolink:MolecularActivity 1-pyrroline-5-carboxylate dehydrogenase activity H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH. EC:1.2.1.88|MetaCyc:RXN-14116|RHEA:16417|RHEA:24882|RHEA:24943|RHEA:28234|RHEA:30235|RHEA:31155|Reactome:R-HSA-6784399|Reactome:R-HSA-70679 go.json 1-pyrroline dehydrogenase|1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity|L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity|delta1-pyrroline-5-carboxylate dehydrogenase activity|pyrroline-5-carboxylate dehydrogenase activity|pyrroline-5-carboxylic acid dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003842 GO:0003845 biolink:MolecularActivity 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+. MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN|Reactome:R-HSA-194023|Wikipedia:11beta-hydroxysteroid_dehydrogenase go.json 11beta-hydroxy steroid dehydrogenase|11beta-hydroxysteroid dehydrogenase|beta-hydroxysteroid dehydrogenase|corticosteroid 11-reductase|corticosteroid 11beta-dehydrogenase http://purl.obolibrary.org/obo/GO_0003845 gocheck_do_not_annotate GO:0003844 biolink:MolecularActivity 1,4-alpha-glucan branching enzyme activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. EC:2.4.1.18|MetaCyc:GLYCOGEN-BRANCH-RXN|Reactome:R-HSA-3322005|Reactome:R-HSA-3322016|Reactome:R-HSA-3322057|Reactome:R-HSA-3878762 go.json 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity|1,4-glucan-6-(1,4-glucano)-transferase activity|Q-enzyme|alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity|alpha-glucan-branching glycosyltransferase activity|amylo-(1,4 to 1,6)transglucosidase activity|amylo-(1,4->1,6)-transglycosylase activity|amylose isomerase activity|branching enzyme activity|branching glycosyltransferase activity|enzymatic branching factor|enzyme Q|glucosan transglycosylase activity|glycogen branching enzyme activity|plant branching enzyme|starch branching enzyme http://purl.obolibrary.org/obo/GO_0003844 GO:0003841 biolink:MolecularActivity 1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. EC:2.3.1.51|MetaCyc:RXN-1623|RHEA:19709|Reactome:R-HSA-1482539|Reactome:R-HSA-1482547|Reactome:R-HSA-1482548|Reactome:R-HSA-1482598|Reactome:R-HSA-1482636|Reactome:R-HSA-1482667|Reactome:R-HSA-1482689|Reactome:R-HSA-1482894|Reactome:R-HSA-75885|Reactome:R-HSA-8849345 go.json 1-acyl-sn-glycero-3-phosphate acyltransferase activity|1-acyl-sn-glycerol 3-phosphate acyltransferase activity|1-acyl-sn-glycerol-3-phosphate acyltransferase activity|1-acylglycero-3-phosphate acyltransferase activity|1-acylglycerolphosphate acyltransferase activity|1-acylglycerophosphate acyltransferase activity|acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity|lysophosphatidate acyltransferase activity|lysophosphatidic acid-acyltransferase activity http://purl.obolibrary.org/obo/GO_0003841 GO:0003840 biolink:MolecularActivity obsolete gamma-glutamyltransferase activity OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. EC:2.3.2.2|KEGG_REACTION:R04159|MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN go.json (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity|L-gamma-glutamyl transpeptidase activity|L-gamma-glutamyltransferase activity|L-glutamyltransferase activity|alpha-glutamyl transpeptidase activity|gamma-GPT|gamma-GT|gamma-GTP|gamma-glutamyl peptidyltransferase activity|gamma-glutamyl transpeptidase activity|glutamyl transpeptidase activity True http://purl.obolibrary.org/obo/GO_0003840 GO:1904329 biolink:BiologicalProcess negative regulation of myofibroblast contraction Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast contraction. go.json down regulation of MF contraction|down regulation of MFB contraction|down regulation of myofibroblast contraction|down-regulation of MF contraction|down-regulation of MFB contraction|down-regulation of myofibroblast contraction|downregulation of MF contraction|downregulation of MFB contraction|downregulation of myofibroblast contraction|inhibition of MF contraction|inhibition of MFB contraction|inhibition of myofibroblast contraction|negative regulation of MF contraction|negative regulation of MFB contraction http://purl.obolibrary.org/obo/GO_1904329 GO:1904328 biolink:BiologicalProcess regulation of myofibroblast contraction Any process that modulates the frequency, rate or extent of myofibroblast contraction. go.json regulation of MF contraction|regulation of MFB contraction http://purl.obolibrary.org/obo/GO_1904328 GO:1904327 biolink:BiologicalProcess protein localization to cytosolic proteasome complex A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex. go.json protein localisation in cytosolic proteasome complex|protein localisation to cytosolic proteasome complex|protein localization in cytosolic proteasome complex http://purl.obolibrary.org/obo/GO_1904327 GO:1904326 biolink:BiologicalProcess negative regulation of circadian sleep/wake cycle, wakefulness Any process that stops, prevents or reduces the frequency, rate or extent of circadian sleep/wake cycle, wakefulness. go.json down regulation of circadian sleep/wake cycle, wakefulness|down-regulation of circadian sleep/wake cycle, wakefulness|downregulation of circadian sleep/wake cycle, wakefulness|inhibition of circadian sleep/wake cycle, wakefulness http://purl.obolibrary.org/obo/GO_1904326 GO:1904325 biolink:BiologicalProcess positive regulation of inhibitory G protein-coupled receptor phosphorylation Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. go.json activation of inhibitory G-protein coupled receptor phosphorylation|positive regulation of inhibitory G-protein coupled receptor phosphorylation|up regulation of inhibitory G-protein coupled receptor phosphorylation|up-regulation of inhibitory G-protein coupled receptor phosphorylation|upregulation of inhibitory G-protein coupled receptor phosphorylation http://purl.obolibrary.org/obo/GO_1904325 GO:0062121 biolink:BiologicalProcess linear element maturation The meiotic cell cycle chromosome organization process in which LinE complexes closely associate with chromatin during meiotic prophase to form mature linear elements. go.json LinE chromosome loading|LinE focus formation http://purl.obolibrary.org/obo/GO_0062121 GO:1904324 biolink:BiologicalProcess negative regulation of inhibitory G protein-coupled receptor phosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. go.json down regulation of inhibitory G-protein coupled receptor phosphorylation|down-regulation of inhibitory G-protein coupled receptor phosphorylation|downregulation of inhibitory G-protein coupled receptor phosphorylation|inhibition of inhibitory G-protein coupled receptor phosphorylation|negative regulation of inhibitory G-protein coupled receptor phosphorylation http://purl.obolibrary.org/obo/GO_1904324 GO:0062120 biolink:BiologicalProcess LinE complex assembly The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins. go.json http://purl.obolibrary.org/obo/GO_0062120 GO:0062123 biolink:BiologicalProcess regulation of linear element maturation Any process that modulates the rate, frequency or extent of linear element maturation. go.json http://purl.obolibrary.org/obo/GO_0062123 GO:1904323 biolink:BiologicalProcess regulation of inhibitory G protein-coupled receptor phosphorylation Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. go.json regulation of inhibitory G-protein coupled receptor phosphorylation http://purl.obolibrary.org/obo/GO_1904323 GO:0062122 biolink:MolecularActivity histone H3K37 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein. go.json histone H3K37 methylase activity|histone lysine N-methyltransferase activity (H3-K37 specific)|histone methyltransferase activity (H3-K37 specific)|histone-H3K37 methyltransferase activity http://purl.obolibrary.org/obo/GO_0062122 GO:1904322 biolink:BiologicalProcess cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. go.json http://purl.obolibrary.org/obo/GO_1904322 GO:0062125 biolink:BiologicalProcess regulation of mitochondrial gene expression Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). go.json http://purl.obolibrary.org/obo/GO_0062125 GO:1904332 biolink:BiologicalProcess negative regulation of error-prone translesion synthesis Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis. go.json down regulation of error-prone postreplication DNA repair|down regulation of error-prone translesion synthesis|down regulation of mutagenic PRR|down regulation of mutagenic postreplication DNA repair|down-regulation of error-prone postreplication DNA repair|down-regulation of error-prone translesion synthesis|down-regulation of mutagenic PRR|down-regulation of mutagenic postreplication DNA repair|downregulation of error-prone postreplication DNA repair|downregulation of error-prone translesion synthesis|downregulation of mutagenic PRR|downregulation of mutagenic postreplication DNA repair|inhibition of error-prone postreplication DNA repair|inhibition of error-prone translesion synthesis|inhibition of mutagenic PRR|inhibition of mutagenic postreplication DNA repair|negative regulation of error-prone postreplication DNA repair|negative regulation of mutagenic PRR|negative regulation of mutagenic postreplication DNA repair http://purl.obolibrary.org/obo/GO_1904332 GO:1904331 biolink:BiologicalProcess regulation of error-prone translesion synthesis Any process that modulates the frequency, rate or extent of error-prone translesion synthesis. go.json regulation of error-prone postreplication DNA repair|regulation of mutagenic PRR|regulation of mutagenic postreplication DNA repair http://purl.obolibrary.org/obo/GO_1904331 GO:0062124 biolink:MolecularActivity 4-hydroxybutyrate receptor activity Combining with 4-hydroxybutyrte to initiate a change in cell activity. go.json gamma-hydroxybutyrate receptor activity http://purl.obolibrary.org/obo/GO_0062124 GO:0062127 biolink:BiologicalProcess fatty acid primary amide catabolic process The chemical reactions and pathways resulting in the breakdown of primary fatty amides. go.json primary fatty amide catabolic process http://purl.obolibrary.org/obo/GO_0062127 GO:1904330 biolink:BiologicalProcess positive regulation of myofibroblast contraction Any process that activates or increases the frequency, rate or extent of myofibroblast contraction. go.json activation of MF contraction|activation of MFB contraction|activation of myofibroblast contraction|positive regulation of MF contraction|positive regulation of MFB contraction|up regulation of MF contraction|up regulation of MFB contraction|up regulation of myofibroblast contraction|up-regulation of MF contraction|up-regulation of MFB contraction|up-regulation of myofibroblast contraction|upregulation of MF contraction|upregulation of MFB contraction|upregulation of myofibroblast contraction http://purl.obolibrary.org/obo/GO_1904330 GO:0062126 biolink:BiologicalProcess fatty acid primary amide metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides. go.json primary fatty amide metabolic process http://purl.obolibrary.org/obo/GO_0062126 GO:0062129 biolink:CellularComponent chitin-based extracellular matrix Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet. go.json chitin-based ECM http://purl.obolibrary.org/obo/GO_0062129 GO:0062128 biolink:CellularComponent MutSgamma complex A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5. go.json Msh4-Msh5 complex http://purl.obolibrary.org/obo/GO_0062128 GO:0003847 biolink:MolecularActivity 1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. EC:3.1.1.47|MetaCyc:3.1.1.47-RXN|RHEA:17777|Reactome:R-HSA-8869206 go.json 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity|1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity|2-acetyl-1-alkylglycerophosphocholine esterase activity|LDL-PLA(2) activity|LDL-PLA2|LDL-associated phospholipase A(2) activity|LDL-associated phospholipase A2|PAF 2-acylhydrolase activity|PAF acetylhydrolase activity|alkylacetyl-GPC:acetylhydrolase activity|platelet-activating factor acetylhydrolase activity http://purl.obolibrary.org/obo/GO_0003847 goslim_chembl GO:0003846 biolink:MolecularActivity 2-acylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. EC:2.3.1.22|MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN|RHEA:16741|Reactome:R-HSA-5696448|Reactome:R-HSA-6800334 go.json acyl coenzyme A-monoglyceride acyltransferase activity|acyl-CoA:2-acylglycerol O-acyltransferase activity|acylglycerol palmitoyltransferase activity|monoacylglycerol acyltransferase activity|monoglyceride acyltransferase activity http://purl.obolibrary.org/obo/GO_0003846 GO:0003849 biolink:MolecularActivity 3-deoxy-7-phosphoheptulonate synthase activity Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. EC:2.5.1.54|KEGG_REACTION:R01826|MetaCyc:DAHPSYN-RXN|RHEA:14717 go.json 2-dehydro-3-deoxy-phosphoheptonate aldolase activity|2-dehydro-3-deoxyphosphoheptonate aldolase activity|2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity|3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity|3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity|3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity|7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate|7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity|7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity|D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity|D-erythrose-4-phosphate-lyase activity|DAH7-P synthase activity|DAHP synthase activity|DHAP synthase activity|DS-Co activity|DS-Mn activity|KDPH synthase activity|KDPH synthetase activity|deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity|phospho-2-dehydro-3-deoxyheptonate aldolase activity|phospho-2-keto-3-deoxyheptanoate aldolase activity|phospho-2-keto-3-deoxyheptonate aldolase activity|phospho-2-keto-3-deoxyheptonic aldolase activity|phospho-2-oxo-3-deoxyheptonate aldolase activity|phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) http://purl.obolibrary.org/obo/GO_0003849 GO:0003848 biolink:MolecularActivity 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+. EC:2.7.6.3|KEGG_REACTION:R03503|MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN|RHEA:11412 go.json 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity|6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity|6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity|7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity|7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity|7,8-dihydroxymethylpterin-pyrophosphokinase activity|ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity|H2-pteridine-CH2OH pyrophosphokinase activity|HPPK|hydroxymethyldihydropteridine pyrophosphokinase activity http://purl.obolibrary.org/obo/GO_0003848 goslim_chembl GO:0003810 biolink:MolecularActivity protein-glutamine gamma-glutamyltransferase activity Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. EC:2.3.2.13|MetaCyc:2.3.2.13-RXN|RESID:AA0124|RHEA:54816|Reactome:R-HSA-140851|Reactome:R-HSA-6810894 go.json R-glutaminyl-peptide:amine gamma-glutamyl transferase activity|TGase activity|factor XIIIa|fibrin stabilizing factor|fibrinoligase activity|glutaminylpeptide gamma-glutamyltransferase activity|polyamine transglutaminase activity|protein-glutamine:amine gamma-glutamyltransferase|tissue transglutaminase|transglutaminase activity http://purl.obolibrary.org/obo/GO_0003810 GO:0003812 biolink:MolecularActivity obsolete alternative-complement-pathway C3/C5 convertase activity OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b. go.json (C3b)n,Bb|(CVF)-dependent glycine-rich-beta-glucoprotein|C3 convertase activity|C3 proactivator|C3b,Bb,CVF,Bb,C5 convertase activity|C5 convertase activity|CVF,Bb|alternative complement pathway C3(C5) convertase activity|alternative-complement-pathway C3/C5 convertase activity|cobra venom factor-dependent C3 convertase|complement C 3(C 5) convertase (amplification)|complement component C3/C5 convertase (alternative) activity|complement factor B activity|glycine-rich beta-glycoprotein|heat-labile factor|proenzyme factor B|properdin factor B activity True http://purl.obolibrary.org/obo/GO_0003812 GO:0003811 biolink:MolecularActivity obsolete complement activity OBSOLETE. Any of a set of activities involved in the complement cascade. go.json complement activity True http://purl.obolibrary.org/obo/GO_0003811 GO:0062150 biolink:MolecularActivity amorpha-4,11-diene 12-monooxygenase activity Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. EC:1.14.14.114|RHEA:32999 go.json http://purl.obolibrary.org/obo/GO_0062150 GO:1904339 biolink:BiologicalProcess negative regulation of dopaminergic neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation. go.json down regulation of dopaminergic neuron differentiation|down-regulation of dopaminergic neuron differentiation|downregulation of dopaminergic neuron differentiation|inhibition of dopaminergic neuron differentiation http://purl.obolibrary.org/obo/GO_1904339 GO:0062152 biolink:MolecularActivity mRNA (cytidine-5-)-methyltransferase activity Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine. RHEA:61464 go.json mRNA (cytosine-5-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0062152 GO:1904338 biolink:BiologicalProcess regulation of dopaminergic neuron differentiation Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation. go.json http://purl.obolibrary.org/obo/GO_1904338 GO:1904337 biolink:BiologicalProcess positive regulation of ductus arteriosus closure Any process that activates or increases the frequency, rate or extent of ductus arteriosus closure. go.json activation of ductus arteriosus closure|up regulation of ductus arteriosus closure|up-regulation of ductus arteriosus closure|upregulation of ductus arteriosus closure http://purl.obolibrary.org/obo/GO_1904337 GO:0062151 biolink:CellularComponent catalase complex A protein-containing complex that is capable of catalase activity. go.json http://purl.obolibrary.org/obo/GO_0062151 GO:1904336 biolink:BiologicalProcess negative regulation of ductus arteriosus closure Any process that stops, prevents or reduces the frequency, rate or extent of ductus arteriosus closure. go.json down regulation of ductus arteriosus closure|down-regulation of ductus arteriosus closure|downregulation of ductus arteriosus closure|inhibition of ductus arteriosus closure http://purl.obolibrary.org/obo/GO_1904336 GO:0062154 biolink:MolecularActivity N6-methyl-AMP deaminase activity Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate. RHEA:16001|Reactome:R-HSA-2161187|Reactome:R-HSA-2161195|Reactome:R-HSA-9731661 go.json MAPDA|N6-mAMP deaminase activity|N6-methyl-AMP/dAMP aminohydrolase http://purl.obolibrary.org/obo/GO_0062154 GO:0062153 biolink:MolecularActivity C5-methylcytidine-containing RNA reader activity A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine. go.json C5-methylcytidine-containing RNA binding|C5-methylcytosine-containing RNA binding http://purl.obolibrary.org/obo/GO_0062153 GO:1904335 biolink:BiologicalProcess regulation of ductus arteriosus closure Any process that modulates the frequency, rate or extent of ductus arteriosus closure. go.json http://purl.obolibrary.org/obo/GO_1904335 GO:0062156 biolink:MolecularActivity mitochondrial ATP-gated potassium channel activity Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane. go.json mitoK-ATP activity|mitochondrial potassium channel activity http://purl.obolibrary.org/obo/GO_0062156 GO:1904334 biolink:BiologicalProcess heme import across plasma membrane The directed movement of heme from outside of a cell, across the plasma membrane and into the cytosol. go.json heme assimilation http://purl.obolibrary.org/obo/GO_1904334 GO:0062155 biolink:CellularComponent curli secretion complex A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms. go.json http://purl.obolibrary.org/obo/GO_0062155 GO:1904333 biolink:BiologicalProcess positive regulation of error-prone translesion synthesis Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis. go.json activation of error-prone postreplication DNA repair|activation of error-prone translesion synthesis|activation of mutagenic PRR|activation of mutagenic postreplication DNA repair|positive regulation of error-prone postreplication DNA repair|positive regulation of mutagenic PRR|positive regulation of mutagenic postreplication DNA repair|up regulation of error-prone postreplication DNA repair|up regulation of error-prone translesion synthesis|up regulation of mutagenic PRR|up regulation of mutagenic postreplication DNA repair|up-regulation of error-prone postreplication DNA repair|up-regulation of error-prone translesion synthesis|up-regulation of mutagenic PRR|up-regulation of mutagenic postreplication DNA repair|upregulation of error-prone postreplication DNA repair|upregulation of error-prone translesion synthesis|upregulation of mutagenic PRR|upregulation of mutagenic postreplication DNA repair http://purl.obolibrary.org/obo/GO_1904333 GO:0062158 biolink:MolecularActivity chloride:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out). go.json http://purl.obolibrary.org/obo/GO_0062158 GO:1904343 biolink:BiologicalProcess positive regulation of colon smooth muscle contraction Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. go.json activation of colon smooth muscle contraction|up regulation of colon smooth muscle contraction|up-regulation of colon smooth muscle contraction|upregulation of colon smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904343 GO:1904342 biolink:BiologicalProcess negative regulation of colon smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. go.json down regulation of colon smooth muscle contraction|down-regulation of colon smooth muscle contraction|downregulation of colon smooth muscle contraction|inhibition of colon smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904342 GO:0062157 biolink:CellularComponent mitochondrial ATP-gated potassium channel complex A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane. go.json http://purl.obolibrary.org/obo/GO_0062157 GO:1904341 biolink:BiologicalProcess regulation of colon smooth muscle contraction Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_1904341 GO:0062159 biolink:CellularComponent contractile vacuole complex A non-membrane-bounded organelle of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally. One of its functions is osmoregulatory. go.json CVC http://purl.obolibrary.org/obo/GO_0062159 GO:1904340 biolink:BiologicalProcess positive regulation of dopaminergic neuron differentiation Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation. go.json activation of dopaminergic neuron differentiation|up regulation of dopaminergic neuron differentiation|up-regulation of dopaminergic neuron differentiation|upregulation of dopaminergic neuron differentiation http://purl.obolibrary.org/obo/GO_1904340 GO:0003818 biolink:MolecularActivity obsolete complement factor I activity OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage. go.json C3b inactivator activity|C3b/C4b inactivator activity|C3bINA|complement C3b inactivator|complement C3b/C4b inactivator|complement C4b inactivator|complement C4bi|complement component C3b inactivator activity|complement factor I activity|conglutinogen-activating factor C|factor I True http://purl.obolibrary.org/obo/GO_0003818 GO:0003817 biolink:MolecularActivity obsolete complement factor D activity OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF). go.json C3 convertase activator activity|C3 proactivator convertase activity|adipsin|complement factor D activity|factor D|factor D (complement)|properdin factor D esterase activity True http://purl.obolibrary.org/obo/GO_0003817 GO:0003819 biolink:MolecularActivity obsolete major histocompatibility complex antigen OBSOLETE. (Was not defined before being made obsolete). go.json MHC protein|major histocompatibility complex antigen True http://purl.obolibrary.org/obo/GO_0003819 GO:0003813 biolink:MolecularActivity obsolete classical-complement-pathway C3/C5 convertase activity OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b. go.json C3 convertase activity|C42|C423|C4b,2a|C4b,2a,3b|C5 convertase activity|classical-complement-pathway C3/C5 convertase activity|complement C2 activity|complement C3 convertase activity|complement C42 True http://purl.obolibrary.org/obo/GO_0003813 GO:0003816 biolink:MolecularActivity obsolete complement component C1s activity OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond). go.json C1 esterase activity|C1s esterase activity|activated complement C1s|complement C1s|complement component C1s activity|complement subcomponent C1s True http://purl.obolibrary.org/obo/GO_0003816 GO:0003815 biolink:MolecularActivity obsolete complement component C1r activity OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42). go.json C1r esterase activity|activated complement C1r|complement component C1r activity|complement subcomponent C1r True http://purl.obolibrary.org/obo/GO_0003815 GO:0003821 biolink:MolecularActivity obsolete class II major histocompatibility complex antigen OBSOLETE. (Was not defined before being made obsolete). go.json class II major histocompatibility complex antigen True http://purl.obolibrary.org/obo/GO_0003821 GO:0003820 biolink:MolecularActivity obsolete class I major histocompatibility complex antigen OBSOLETE. (Was not defined before being made obsolete). go.json class I major histocompatibility complex antigen True http://purl.obolibrary.org/obo/GO_0003820 GO:0003823 biolink:MolecularActivity antigen binding Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell. go.json B cell receptor activity|MHC activity|antibody activity|major histocompatibility complex activity|major histocompatibility complex antigen display activity|opsonin activity http://purl.obolibrary.org/obo/GO_0003823 goslim_chembl|goslim_pir GO:0003822 biolink:MolecularActivity obsolete MHC-interacting protein OBSOLETE. (Was not defined before being made obsolete). go.json MHC-interacting protein True http://purl.obolibrary.org/obo/GO_0003822 GO:0062141 biolink:CellularComponent nuclear exosome targeting complex A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts. go.json NEXT complex http://purl.obolibrary.org/obo/GO_0062141 GO:1904349 biolink:BiologicalProcess positive regulation of small intestine smooth muscle contraction Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. go.json activation of small intestine smooth muscle contraction|up regulation of small intestine smooth muscle contraction|up-regulation of small intestine smooth muscle contraction|upregulation of small intestine smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904349 GO:0062140 biolink:CellularComponent hyphae septin collar A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell. go.json septin collar of invasive hyphae http://purl.obolibrary.org/obo/GO_0062140 GO:1904348 biolink:BiologicalProcess negative regulation of small intestine smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. go.json down regulation of small intestine smooth muscle contraction|down-regulation of small intestine smooth muscle contraction|downregulation of small intestine smooth muscle contraction|inhibition of small intestine smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904348 GO:1904347 biolink:BiologicalProcess regulation of small intestine smooth muscle contraction Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_1904347 GO:0062143 biolink:BiologicalProcess L-propargylglycine biosynthetic process The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria. go.json http://purl.obolibrary.org/obo/GO_0062143 GO:1904346 biolink:BiologicalProcess positive regulation of gastric mucosal blood circulation Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. go.json activation of gastric mucosal blood circulation|activation of stomach mucosal blood circulation|positive regulation of stomach mucosal blood circulation|up regulation of gastric mucosal blood circulation|up regulation of stomach mucosal blood circulation|up-regulation of gastric mucosal blood circulation|up-regulation of stomach mucosal blood circulation|upregulation of gastric mucosal blood circulation|upregulation of stomach mucosal blood circulation http://purl.obolibrary.org/obo/GO_1904346 GO:0062142 biolink:BiologicalProcess L-beta-ethynylserine biosynthetic process The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria. go.json http://purl.obolibrary.org/obo/GO_0062142 GO:0062145 biolink:MolecularActivity L-propargylglycine--L-glutamate ligase activity Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H+ + L-gamma-glutamyl-L-propargylglycine + phosphate. RHEA:59896 go.json http://purl.obolibrary.org/obo/GO_0062145 GO:1904345 biolink:BiologicalProcess negative regulation of gastric mucosal blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. go.json down regulation of gastric mucosal blood circulation|down regulation of stomach mucosal blood circulation|down-regulation of gastric mucosal blood circulation|down-regulation of stomach mucosal blood circulation|downregulation of gastric mucosal blood circulation|downregulation of stomach mucosal blood circulation|inhibition of gastric mucosal blood circulation|inhibition of stomach mucosal blood circulation|negative regulation of stomach mucosal blood circulation http://purl.obolibrary.org/obo/GO_1904345 GO:0062144 biolink:MolecularActivity L-propargylglycine synthase activity Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H+ + L-propargylglycine. RHEA:59892 go.json http://purl.obolibrary.org/obo/GO_0062144 GO:1904344 biolink:BiologicalProcess regulation of gastric mucosal blood circulation Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. go.json regulation of stomach mucosal blood circulation http://purl.obolibrary.org/obo/GO_1904344 GO:0062147 biolink:MolecularActivity L-lysine 4-chlorinase activity Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate. RHEA:59884 go.json http://purl.obolibrary.org/obo/GO_0062147 GO:1904354 biolink:BiologicalProcess negative regulation of telomere capping Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping. go.json down regulation of telomere capping|down regulation of telomere end protection|down-regulation of telomere capping|down-regulation of telomere end protection|downregulation of telomere capping|downregulation of telomere end protection|inhibition of telomere capping|inhibition of telomere end protection|negative regulation of telomere end protection http://purl.obolibrary.org/obo/GO_1904354 GO:0086103 biolink:BiologicalProcess G protein-coupled receptor signaling pathway involved in heart process An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart. go.json G-protein coupled receptor signaling pathway involved in heart process|G-protein coupled receptor signalling pathway involved in heart process|GPCR signaling pathway involved in cardiac process|GPCR signaling pathway involved in heart process http://purl.obolibrary.org/obo/GO_0086103 GO:0086102 biolink:BiologicalProcess adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate An adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate. go.json AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate|G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity|Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate|muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel|muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current http://purl.obolibrary.org/obo/GO_0086102 GO:1904353 biolink:BiologicalProcess regulation of telomere capping Any process that modulates the frequency, rate or extent of telomere capping. go.json regulation of telomere end protection http://purl.obolibrary.org/obo/GO_1904353 GO:0062146 biolink:MolecularActivity 4-chloro-allylglycine synthase activity Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+). RHEA:59888 go.json http://purl.obolibrary.org/obo/GO_0062146 GO:1904352 biolink:BiologicalProcess positive regulation of protein catabolic process in the vacuole Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. go.json activation of protein catabolic process in the vacuole|activation of vacuolar protein breakdown|activation of vacuolar protein catabolic process|activation of vacuolar protein catabolism|activation of vacuolar protein degradation|positive regulation of vacuolar protein breakdown|positive regulation of vacuolar protein catabolic process|positive regulation of vacuolar protein catabolism|positive regulation of vacuolar protein degradation|up regulation of protein catabolic process in the vacuole|up regulation of vacuolar protein breakdown|up regulation of vacuolar protein catabolic process|up regulation of vacuolar protein catabolism|up regulation of vacuolar protein degradation|up-regulation of protein catabolic process in the vacuole|up-regulation of vacuolar protein breakdown|up-regulation of vacuolar protein catabolic process|up-regulation of vacuolar protein catabolism|up-regulation of vacuolar protein degradation|upregulation of protein catabolic process in the vacuole|upregulation of vacuolar protein breakdown|upregulation of vacuolar protein catabolic process|upregulation of vacuolar protein catabolism|upregulation of vacuolar protein degradation http://purl.obolibrary.org/obo/GO_1904352 GO:0086101 biolink:BiologicalProcess endothelin receptor signaling pathway involved in heart process An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart. go.json endothelin receptor signalling pathway involved in heart process http://purl.obolibrary.org/obo/GO_0086101 GO:0062149 biolink:BiologicalProcess detection of stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0062149 GO:0086100 biolink:BiologicalProcess endothelin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json endothelin signaling pathway http://purl.obolibrary.org/obo/GO_0086100 GO:1904351 biolink:BiologicalProcess negative regulation of protein catabolic process in the vacuole Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. go.json down regulation of protein catabolic process in the vacuole|down regulation of vacuolar protein breakdown|down regulation of vacuolar protein catabolic process|down regulation of vacuolar protein catabolism|down regulation of vacuolar protein degradation|down-regulation of protein catabolic process in the vacuole|down-regulation of vacuolar protein breakdown|down-regulation of vacuolar protein catabolic process|down-regulation of vacuolar protein catabolism|down-regulation of vacuolar protein degradation|downregulation of protein catabolic process in the vacuole|downregulation of vacuolar protein breakdown|downregulation of vacuolar protein catabolic process|downregulation of vacuolar protein catabolism|downregulation of vacuolar protein degradation|inhibition of protein catabolic process in the vacuole|inhibition of vacuolar protein breakdown|inhibition of vacuolar protein catabolic process|inhibition of vacuolar protein catabolism|inhibition of vacuolar protein degradation|negative regulation of vacuolar protein breakdown|negative regulation of vacuolar protein catabolic process|negative regulation of vacuolar protein catabolism|negative regulation of vacuolar protein degradation http://purl.obolibrary.org/obo/GO_1904351 GO:0062148 biolink:MolecularActivity L-gamma-glutamyl-L-propargylglycine hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate. RHEA:59900 go.json http://purl.obolibrary.org/obo/GO_0062148 GO:1904350 biolink:BiologicalProcess regulation of protein catabolic process in the vacuole Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. go.json regulation of vacuolar protein breakdown|regulation of vacuolar protein catabolic process|regulation of vacuolar protein catabolism|regulation of vacuolar protein degradation http://purl.obolibrary.org/obo/GO_1904350 GO:0003829 biolink:MolecularActivity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. EC:2.4.1.102|MetaCyc:2.4.1.102-RXN|RHEA:18705|Reactome:R-HSA-914012|Reactome:R-HSA-914018 go.json O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity|beta(6)-N-acetylglucosaminyltransferase activity|beta6-N-acetylglucosaminyltransferase activity|core 2 acetylglucosaminyltransferase activity|core 6-beta-GlcNAc-transferase A|uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0003829 GO:0003828 biolink:MolecularActivity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. EC:2.4.3.8|MetaCyc:2.4.99.8-RXN|RHEA:19313|Reactome:R-HSA-1022133|Reactome:R-HSA-4084978|Reactome:R-HSA-422454 go.json alpha-2,8-sialyltransferase activity|alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity|cytidine monophosphoacetylneuraminate-ganglioside GM3|ganglioside GD3 synthase activity|ganglioside GD3 synthetase sialyltransferase activity http://purl.obolibrary.org/obo/GO_0003828 GO:0003825 biolink:MolecularActivity alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. EC:2.4.1.15|MetaCyc:TREHALOSE6PSYN-RXN|RHEA:18889 go.json UDP-glucose-glucose-phosphate glucosyltransferase activity|UDP-glucose-glucosephosphate glucosyltransferase activity|UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|UDPglucose-glucose-phosphate glucosyltransferase activity|UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|alpha,alpha-trehalose phosphate synthase (UDP-forming)|phosphotrehalose-uridine diphosphate transglucosylase activity|transglucosylase activity|trehalose 6-phosphate synthase activity|trehalose 6-phosphate synthetase activity|trehalose phosphate synthase activity|trehalose phosphate synthetase activity|trehalose phosphate-uridine diphosphate glucosyltransferase activity|trehalose-P synthetase activity|trehalose-phosphate synthase activity|trehalose-phosphate synthetase activity|trehalosephosphate-UDP glucosyl transferase activity|trehalosephosphate-UDP glucosyltransferase activity|uridine diphosphoglucose phosphate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0003825 GO:0003824 biolink:MolecularActivity catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Wikipedia:Enzyme go.json enzyme activity http://purl.obolibrary.org/obo/GO_0003824 goslim_agr|goslim_chembl|goslim_flybase_ribbon|goslim_generic|goslim_metagenomics|goslim_pir|goslim_plant GO:0003827 biolink:MolecularActivity alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP. EC:2.4.1.101|KEGG_REACTION:R05983|MetaCyc:2.4.1.101-RXN|RHEA:11456|Reactome:R-HSA-964768 go.json GNTI activity|GnTI|N-acetylglucosaminyltransferase I activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity|UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity|UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity|UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity|alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity|alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0003827 GO:0003826 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003826 GO:0062170 biolink:BiologicalProcess lutein metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform lutein. go.json lutein metabolism http://purl.obolibrary.org/obo/GO_0062170 GO:0062172 biolink:BiologicalProcess lutein catabolic process The chemical reactions and pathways resulting in the breakdown of lutein. go.json lutein breakdown|lutein catabolism|lutein degradation http://purl.obolibrary.org/obo/GO_0062172 GO:0062171 biolink:BiologicalProcess lutein biosynthetic process The chemical reactions and pathways resulting in the formation of lutein. go.json lutein anabolism|lutein biosynthesis|lutein formation http://purl.obolibrary.org/obo/GO_0062171 GO:0062174 biolink:BiologicalProcess brexanolone biosynthetic process The chemical reactions and pathways resulting in the formation of brexanolone. go.json allopregnanolone anabolism|allopregnanolone biosynthesis|allopregnanolone biosynthetic process|allopregnanolone synthesis|allotetrahydroprogesterone anabolism|allotetrahydroprogesterone biosynthesis|allotetrahydroprogesterone biosynthetic process|allotetrahydroprogesterone synthesis|brexanolone anabolism|brexanolone biosynthesis|brexanolone synthesis http://purl.obolibrary.org/obo/GO_0062174 GO:1904359 biolink:BiologicalProcess regulation of spore germination Any process that modulates the frequency, rate or extent of spore germination. go.json modulation of spore germination on or near host http://purl.obolibrary.org/obo/GO_1904359 GO:0062173 biolink:BiologicalProcess brexanolone metabolic process The chemical reactions and pathways by which living organisms transform brexanolone. go.json allopregnanolone metabolic process|allopregnanolone metabolism|allotetrahydroprogesterone metabolic process|allotetrahydroprogesterone metabolism|brexanolone metabolism http://purl.obolibrary.org/obo/GO_0062173 GO:0062176 biolink:BiologicalProcess R-loop processing A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability. go.json R-loop disassembly http://purl.obolibrary.org/obo/GO_0062176 GO:1904358 biolink:BiologicalProcess positive regulation of telomere maintenance via telomere lengthening Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. go.json activation of telomere maintenance via telomere lengthening|up regulation of telomere maintenance via telomere lengthening|up-regulation of telomere maintenance via telomere lengthening|upregulation of telomere maintenance via telomere lengthening http://purl.obolibrary.org/obo/GO_1904358 GO:0062175 biolink:BiologicalProcess brexanolone catabolic process The chemical reactions and pathways resulting in the breakdown of brexanolone. go.json allopregnanolone breakdown|allopregnanolone catabolic process|allopregnanolone catabolism|allopregnanolone degradation|allotetrahydroprogesterone breakdown|allotetrahydroprogesterone catabolic process|allotetrahydroprogesterone catabolism|allotetrahydroprogesterone degradation|brexanolone breakdown|brexanolone catabolism|brexanolone degradation http://purl.obolibrary.org/obo/GO_0062175 GO:1904357 biolink:BiologicalProcess negative regulation of telomere maintenance via telomere lengthening Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. go.json down regulation of telomere maintenance via telomere lengthening|down-regulation of telomere maintenance via telomere lengthening|downregulation of telomere maintenance via telomere lengthening|inhibition of telomere maintenance via telomere lengthening http://purl.obolibrary.org/obo/GO_1904357 GO:1904356 biolink:BiologicalProcess regulation of telomere maintenance via telomere lengthening Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. go.json http://purl.obolibrary.org/obo/GO_1904356 GO:0062178 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0062178 GO:1904355 biolink:BiologicalProcess positive regulation of telomere capping Any process that activates or increases the frequency, rate or extent of telomere capping. go.json activation of telomere capping|activation of telomere end protection|positive regulation of telomere end protection|up regulation of telomere capping|up regulation of telomere end protection|up-regulation of telomere capping|up-regulation of telomere end protection|upregulation of telomere capping|upregulation of telomere end protection http://purl.obolibrary.org/obo/GO_1904355 GO:0062177 biolink:BiologicalProcess radial spoke assembly The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. go.json http://purl.obolibrary.org/obo/GO_0062177 GO:1904365 biolink:BiologicalProcess regulation of chemokinesis Any process that modulates the frequency, rate or extent of chemokinesis. go.json http://purl.obolibrary.org/obo/GO_1904365 GO:1904364 biolink:BiologicalProcess positive regulation of calcitonin secretion Any process that activates or increases the frequency, rate or extent of calcitonin secretion. go.json activation of calcitonin secretion|up regulation of calcitonin secretion|up-regulation of calcitonin secretion|upregulation of calcitonin secretion http://purl.obolibrary.org/obo/GO_1904364 GO:0062179 biolink:MolecularActivity vitamin D 23-hydroxylase activity Catalysis of the hydroxylation of C-23 of any form of vitamin D. go.json http://purl.obolibrary.org/obo/GO_0062179 GO:1904363 biolink:BiologicalProcess negative regulation of calcitonin secretion Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion. go.json down regulation of calcitonin secretion|down-regulation of calcitonin secretion|downregulation of calcitonin secretion|inhibition of calcitonin secretion http://purl.obolibrary.org/obo/GO_1904363 GO:1904362 biolink:BiologicalProcess regulation of calcitonin secretion Any process that modulates the frequency, rate or extent of calcitonin secretion. go.json http://purl.obolibrary.org/obo/GO_1904362 GO:1904361 biolink:BiologicalProcess positive regulation of spore germination Any process that activates or increases the frequency, rate or extent of spore germination. go.json activation of spore germination|positive regulation of spore germination on or near host|up regulation of spore germination|up-regulation of spore germination|upregulation of spore germination http://purl.obolibrary.org/obo/GO_1904361 GO:1904360 biolink:BiologicalProcess negative regulation of spore germination Any process that stops, prevents or reduces the frequency, rate or extent of spore germination. go.json down regulation of spore germination|down-regulation of spore germination|downregulation of spore germination|inhibition of spore germination|negative regulation of spore germination on or near host http://purl.obolibrary.org/obo/GO_1904360 GO:0003801 biolink:MolecularActivity obsolete blood coagulation factor activity OBSOLETE. (Was not defined before being made obsolete). go.json blood coagulation factor activity True http://purl.obolibrary.org/obo/GO_0003801 GO:0003800 biolink:MolecularActivity obsolete antiviral response protein activity OBSOLETE. A protein involved in an antiviral response. go.json antiviral response protein activity True http://purl.obolibrary.org/obo/GO_0003800 GO:0062161 biolink:BiologicalProcess regulation of pyocyanine biosynthetic process Any process that modulates the frequency, rate or extent of a pyocyanine biosynthetic process. go.json regulation of pyocyanin biosynthetic process http://purl.obolibrary.org/obo/GO_0062161 GO:0062160 biolink:CellularComponent spongiome A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory. go.json http://purl.obolibrary.org/obo/GO_0062160 GO:0062163 biolink:BiologicalProcess pseudohyphal septin ring assembly The aggregation, arrangement and bonding together of septins and associated proteins to form a tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection. go.json http://purl.obolibrary.org/obo/GO_0062163 GO:0062162 biolink:BiologicalProcess positive regulation of pyocyanine biosynthetic process Any process that increases the frequency, rate or extent of a pyocyanine biosynthetic process. go.json positive regulation of pyocyanin biosynthetic process http://purl.obolibrary.org/obo/GO_0062162 GO:0062165 biolink:BiologicalProcess positive regulation of pseudohyphal septin ring assembly Any process that increases the rate, frequency or extent of pseudohyphal septin ring formation. go.json http://purl.obolibrary.org/obo/GO_0062165 GO:1904369 biolink:BiologicalProcess positive regulation of sclerenchyma cell differentiation Any process that activates or increases the frequency, rate or extent of sclerenchyma cell differentiation. go.json up regulation of sclerenchyma cell differentiation|up-regulation of sclerenchyma cell differentiation|upregulation of sclerenchyma cell differentiation http://purl.obolibrary.org/obo/GO_1904369 GO:0062164 biolink:BiologicalProcess regulation of pseudohyphal septin ring assembly Any process that modulates the rate, frequency or extent of pseudohyphal septin ring assembly. go.json http://purl.obolibrary.org/obo/GO_0062164 GO:1904368 biolink:BiologicalProcess regulation of sclerenchyma cell differentiation Any process that modulates the frequency, rate or extent of sclerenchyma cell differentiation. go.json http://purl.obolibrary.org/obo/GO_1904368 GO:1904367 biolink:BiologicalProcess positive regulation of chemokinesis Any process that activates or increases the frequency, rate or extent of chemokinesis. go.json activation of chemokinesis|up regulation of chemokinesis|up-regulation of chemokinesis|upregulation of chemokinesis http://purl.obolibrary.org/obo/GO_1904367 GO:0062167 biolink:CellularComponent complement component C1q complex A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning. go.json C1q|Complement 1q http://purl.obolibrary.org/obo/GO_0062167 GO:1904366 biolink:BiologicalProcess negative regulation of chemokinesis Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis. go.json down regulation of chemokinesis|down-regulation of chemokinesis|downregulation of chemokinesis|inhibition of chemokinesis http://purl.obolibrary.org/obo/GO_1904366 GO:0062166 biolink:BiologicalProcess negative regulation of pseudohyphal septin ring assembly Any process that decreases the rate, frequency or extent of pseudohyphal septin ring assembly. go.json http://purl.obolibrary.org/obo/GO_0062166 GO:1904376 biolink:BiologicalProcess negative regulation of protein localization to cell periphery Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. go.json down regulation of protein localization to cell periphery|down-regulation of protein localization to cell periphery|downregulation of protein localization to cell periphery|inhibition of protein localization to cell periphery http://purl.obolibrary.org/obo/GO_1904376 GO:0062169 biolink:BiologicalProcess regulation of plus-end directed microtubule sliding Any process that mediates the frequency, rate, or extent of plus-end directed microtubule sliding. go.json http://purl.obolibrary.org/obo/GO_0062169 GO:0062168 biolink:BiologicalProcess negative regulation of plus-end directed microtubule sliding Any process that stops, prevents, or reduces the frequency, rate, or extent of plus-end directed microtubule sliding. go.json http://purl.obolibrary.org/obo/GO_0062168 GO:1904375 biolink:BiologicalProcess regulation of protein localization to cell periphery Any process that modulates the frequency, rate or extent of protein localization to cell periphery. go.json http://purl.obolibrary.org/obo/GO_1904375 GO:1904374 biolink:BiologicalProcess cellular response to kainic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1904374 GO:1904373 biolink:BiologicalProcess response to kainic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_1904373 GO:1904372 biolink:BiologicalProcess positive regulation of protein localization to actin cortical patch Any process that activates or increases the frequency, rate or extent of protein localization to actin cortical patch. go.json activation of protein localisation to actin cortical patch|activation of protein localization to actin cortical patch|positive regulation of protein localisation to actin cortical patch|up regulation of protein localisation to actin cortical patch|up regulation of protein localization to actin cortical patch|up-regulation of protein localisation to actin cortical patch|up-regulation of protein localization to actin cortical patch|upregulation of protein localisation to actin cortical patch|upregulation of protein localization to actin cortical patch http://purl.obolibrary.org/obo/GO_1904372 GO:1904371 biolink:BiologicalProcess negative regulation of protein localization to actin cortical patch Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to actin cortical patch. go.json down regulation of protein localisation to actin cortical patch|down regulation of protein localization to actin cortical patch|down-regulation of protein localisation to actin cortical patch|down-regulation of protein localization to actin cortical patch|downregulation of protein localisation to actin cortical patch|downregulation of protein localization to actin cortical patch|inhibition of protein localisation to actin cortical patch|inhibition of protein localization to actin cortical patch|negative regulation of protein localisation to actin cortical patch http://purl.obolibrary.org/obo/GO_1904371 GO:1904370 biolink:BiologicalProcess regulation of protein localization to actin cortical patch Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch. go.json regulation of protein localisation to actin cortical patch http://purl.obolibrary.org/obo/GO_1904370 GO:0003807 biolink:MolecularActivity obsolete plasma kallikrein activity OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin. go.json callicrein|depot-padutin|dilminal D|glumorin|kallidinogenase|kallikrein|kallikrein I|kallikrein II|kininogenase|kininogenin activity|onokrein P|padreatin|padutin|panceatic kallikrein|plasma kallikrein activity|serum kallikrein activity|urinary kallikrein|urokallikrein True http://purl.obolibrary.org/obo/GO_0003807 GO:0003806 biolink:MolecularActivity obsolete coagulation factor XIIa activity OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa. go.json activated beta blood-coagulation factor XII|blood coagulation factor XII activity|blood-coagulation factor XIIabeta|blood-coagulation factor XIIf|coagulation factor XIIa activity|hageman factor (activated)|hageman factor activity|hageman factor beta-fragment|hageman factor fragment HFf|kallikreinogen activator|prealbumin activator|prekallikrein activator True http://purl.obolibrary.org/obo/GO_0003806 GO:0003809 biolink:MolecularActivity obsolete thrombin activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B. go.json E thrombin|activated blood-coagulation factor II|beta-thrombin|blood-coagulation factor IIa|factor IIa|fibrinogenase activity|gamma-thrombin|thrombase activity|thrombin activity|thrombin-C|thrombofort|topical|tropostasin True http://purl.obolibrary.org/obo/GO_0003809 GO:0003808 biolink:MolecularActivity obsolete protein C (activated) activity OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa. go.json GSAPC|activated blood coagulation factor XIV activity|activated protein C|autoprothrombin II-A|autoprothrombin IIA activity|blood-coagulation factor XIVa|protein C (activated) activity|protein Ca True http://purl.obolibrary.org/obo/GO_0003808 GO:0003803 biolink:MolecularActivity obsolete coagulation factor IXa activity OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa. go.json Christmas factor activity|activated blood coagulation factor XI|activated blood-coagulation factor IX|activated christmas factor|autoprothrombin II|blood coagulation factor IX activity|blood platelet cofactor II|blood-coagulation factor IXa|coagulation factor IXa activity True http://purl.obolibrary.org/obo/GO_0003803 GO:0003802 biolink:MolecularActivity obsolete coagulation factor VIIa activity OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta. go.json activated blood coagulation factor VII|blood coagulation factor VII activity|blood-coagulation factor VIIa|coagulation factor VIIa activity True http://purl.obolibrary.org/obo/GO_0003802 GO:0003805 biolink:MolecularActivity obsolete coagulation factor XIa activity OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa. go.json activated blood-coagulation factor XI|activated plasma thromboplastin antecedent|blood coagulation factor XI activity|blood-coagulation factor XIa|coagulation factor XIa activity|plasma thromboplastin antecedent activity True http://purl.obolibrary.org/obo/GO_0003805 GO:0003804 biolink:MolecularActivity obsolete coagulation factor Xa activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa). go.json Stuart factor|Stuart factor activity|activated Stuart-Prower factor|activated blood-coagulation factor X|activated factor X|autoprothrombin C|blood coagulation factor X activity|coagulation factor Xa activity|factor Xa|plasma thromboplastin|prothrombase activity|prothrombinase activity|thrombokinase activity|thromboplastin True http://purl.obolibrary.org/obo/GO_0003804 GO:0062192 biolink:MolecularActivity L-rhamnose mutarotase activity Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose. EC:5.1.3.32|RHEA:25584 go.json http://purl.obolibrary.org/obo/GO_0062192 GO:0062191 biolink:BiologicalProcess galactoxylomannan biosynthetic process The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals. go.json GalXM biosynthetic process|galactoxylomannan anabolism|galactoxylomannan biosynthesis|galactoxylomannan formation|galactoxylomannan synthesis|glucuronoxylomannogalactan biosynthetic process http://purl.obolibrary.org/obo/GO_0062191 GO:0062194 biolink:CellularComponent cytoplasmic microtubule minus-end A microtubule minus end that is part of a cytoplasmic microtubule. go.json http://purl.obolibrary.org/obo/GO_0062194 GO:0062193 biolink:MolecularActivity D-ribose pyranase activity Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose. EC:5.4.99.62|RHEA:25432 go.json http://purl.obolibrary.org/obo/GO_0062193 GO:0062196 biolink:BiologicalProcess regulation of lysosome size Any process that modulates the size of a lysosome. go.json http://purl.obolibrary.org/obo/GO_0062196 GO:0062195 biolink:BiologicalProcess microtubule bundle maintenance The organization process that preserves a microtubule bundle in a stable functional or structural state. go.json http://purl.obolibrary.org/obo/GO_0062195 GO:0062198 biolink:CellularComponent obsolete rDNA replication pause site heterochromatin OBSOLETE. A region of heterochromatin associated with sites in rDNA repeats where replication forks pause. go.json True http://purl.obolibrary.org/obo/GO_0062198 GO:1904379 biolink:BiologicalProcess protein localization to cytosolic proteasome complex involved in ERAD pathway Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation. go.json protein localisation in cytosolic proteasome complex involved in ER-associated degradation pathway|protein localisation in cytosolic proteasome complex involved in ERAD pathway|protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway|protein localisation to cytosolic proteasome complex involved in ER-associated degradation pathway|protein localisation to cytosolic proteasome complex involved in ERAD pathway|protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway|protein localization in cytosolic proteasome complex involved in ER-associated degradation pathway|protein localization in cytosolic proteasome complex involved in ERAD pathway|protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway|protein localization to cytosolic proteasome complex involved in ER-associated degradation pathway|protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway http://purl.obolibrary.org/obo/GO_1904379 GO:0062197 biolink:BiologicalProcess cellular response to chemical stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress. go.json http://purl.obolibrary.org/obo/GO_0062197 GO:1904378 biolink:BiologicalProcess maintenance of unfolded protein involved in ERAD pathway Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome. go.json ERAD chaperone-like activity|chaperone holdase activity|holdase activity|maintenance of unfolded protein during ERAD|maintenance of unfolded protein involved in ER-associated degradation pathway|maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation|maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway http://purl.obolibrary.org/obo/GO_1904378 GO:1904377 biolink:BiologicalProcess positive regulation of protein localization to cell periphery Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. go.json activation of protein localization to cell periphery|up regulation of protein localization to cell periphery|up-regulation of protein localization to cell periphery|upregulation of protein localization to cell periphery http://purl.obolibrary.org/obo/GO_1904377 GO:0062199 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0062199 GO:1904387 biolink:BiologicalProcess cellular response to L-phenylalanine derivative Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus. go.json http://purl.obolibrary.org/obo/GO_1904387 GO:1904386 biolink:BiologicalProcess response to L-phenylalanine derivative Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus. go.json http://purl.obolibrary.org/obo/GO_1904386 GO:1904385 biolink:BiologicalProcess cellular response to angiotensin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. go.json http://purl.obolibrary.org/obo/GO_1904385 GO:1904384 biolink:BiologicalProcess cellular response to sodium phosphate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. go.json http://purl.obolibrary.org/obo/GO_1904384 GO:1904383 biolink:BiologicalProcess response to sodium phosphate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. go.json http://purl.obolibrary.org/obo/GO_1904383 GO:1904382 biolink:BiologicalProcess mannose trimming involved in glycoprotein ERAD pathway The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD). go.json glycoprotein mannose trimming involved in ER-associated glycoprotein degradation|glycoprotein mannose trimming involved in glycoprotein ERAD|glycoprotein mannose trimming involved in glycoprotein ERAD pathway|glycoprotein mannose trimming involved in gpERAD|mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process|protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation|protein alpha-1,2-demannosylation involved in glycoprotein ERAD|protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway|protein alpha-1,2-demannosylation involved in gpERAD http://purl.obolibrary.org/obo/GO_1904382 gocheck_do_not_annotate GO:1904381 biolink:BiologicalProcess Golgi apparatus mannose trimming Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus. go.json glycoprotein mannose trimming in Golgi apparatus|glycoprotein mannose trimming in Golgi complex|glycoprotein mannose trimming in Golgi ribbon|mannose trimming in Golgi|mannose trimming in Golgi apparatus|mannose trimming in cis-Golgi|protein alpha-1,2-demannosylation in Golgi apparatus|protein alpha-1,2-demannosylation in Golgi complex|protein alpha-1,2-demannosylation in Golgi ribbon http://purl.obolibrary.org/obo/GO_1904381 gocheck_do_not_annotate GO:1904380 biolink:BiologicalProcess endoplasmic reticulum mannose trimming Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC). go.json ER mannose trimming|ER protein alpha-1,2-demannosylation|glycoprotein mannose trimming in ER quality control compartment|glycoprotein mannose trimming in ER-derived quality control compartment|glycoprotein mannose trimming in ERQC|glycoprotein mannose trimming in endoplasmic reticulum quality control compartment|protein alpha-1,2-demannosylation in ER|protein alpha-1,2-demannosylation in ER quality control compartment|protein alpha-1,2-demannosylation in ER-derived quality control compartment|protein alpha-1,2-demannosylation in ERQC|protein alpha-1,2-demannosylation in endoplasmic reticulum|protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment http://purl.obolibrary.org/obo/GO_1904380 gocheck_do_not_annotate GO:0062181 biolink:MolecularActivity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]. RHEA:49192 go.json http://purl.obolibrary.org/obo/GO_0062181 GO:0062180 biolink:MolecularActivity 25-hydroxycholecalciferol-23-hydroxylase activity Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]. RHEA:46616 go.json http://purl.obolibrary.org/obo/GO_0062180 GO:0062183 biolink:MolecularActivity all-trans retinoic acid 18-hydroxylase activity Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. RHEA:55856 go.json http://purl.obolibrary.org/obo/GO_0062183 GO:0062182 biolink:MolecularActivity all-trans retinoic acid 4-hydrolase activity Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. RHEA:51492 go.json http://purl.obolibrary.org/obo/GO_0062182 GO:0062185 biolink:MolecularActivity secalciferol 1-monooxygenase activity Catalysis of the reaction:2 H+ + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]. RHEA:49064 go.json http://purl.obolibrary.org/obo/GO_0062185 GO:0062184 biolink:MolecularActivity testosterone 16-beta-hydroxylase activity Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. RHEA:46304 go.json http://purl.obolibrary.org/obo/GO_0062184 GO:0062187 biolink:MolecularActivity anandamide 8,9 epoxidase activity Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. RHEA:53140 go.json http://purl.obolibrary.org/obo/GO_0062187 GO:0062186 biolink:MolecularActivity anandamide epoxidase activity Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide. go.json arachidonoylethanolamide epoxidase activity http://purl.obolibrary.org/obo/GO_0062186 GO:1904389 biolink:BiologicalProcess rod bipolar cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell. go.json http://purl.obolibrary.org/obo/GO_1904389 GO:0062189 biolink:MolecularActivity anandamide 14,15 epoxidase activity Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. RHEA:53148 go.json http://purl.obolibrary.org/obo/GO_0062189 GO:1904388 biolink:BiologicalProcess negative regulation of ncRNA transcription associated with protein coding gene TSS/TES Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES. go.json down regulation of ncRNA transcription associated with protein coding gene TSS/TES|down regulation of pasRNA transcription|down-regulation of ncRNA transcription associated with protein coding gene TSS/TES|down-regulation of pasRNA transcription|downregulation of ncRNA transcription associated with protein coding gene TSS/TES|downregulation of pasRNA transcription|inhibition of ncRNA transcription associated with protein coding gene TSS/TES|inhibition of pasRNA transcription|negative regulation of pasRNA transcription http://purl.obolibrary.org/obo/GO_1904388 GO:0062188 biolink:MolecularActivity anandamide 11,12 epoxidase activity Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. RHEA:53144 go.json http://purl.obolibrary.org/obo/GO_0062188 GO:1904398 biolink:BiologicalProcess positive regulation of neuromuscular junction development Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. go.json activation of NMJ stability|activation of neuromuscular junction development|activation of neuromuscular junction organization|activation of neuromuscular junction stability|positive regulation of NMJ stability|positive regulation of neuromuscular junction organization|positive regulation of neuromuscular junction stability|up regulation of NMJ stability|up regulation of neuromuscular junction development|up regulation of neuromuscular junction organization|up regulation of neuromuscular junction stability|up-regulation of NMJ stability|up-regulation of neuromuscular junction development|up-regulation of neuromuscular junction organization|up-regulation of neuromuscular junction stability|upregulation of NMJ stability|upregulation of neuromuscular junction development|upregulation of neuromuscular junction organization|upregulation of neuromuscular junction stability http://purl.obolibrary.org/obo/GO_1904398 GO:1904397 biolink:BiologicalProcess negative regulation of neuromuscular junction development Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. go.json down regulation of NMJ stability|down regulation of neuromuscular junction development|down regulation of neuromuscular junction organization|down regulation of neuromuscular junction stability|down-regulation of NMJ stability|down-regulation of neuromuscular junction development|down-regulation of neuromuscular junction organization|down-regulation of neuromuscular junction stability|downregulation of NMJ stability|downregulation of neuromuscular junction development|downregulation of neuromuscular junction organization|downregulation of neuromuscular junction stability|inhibition of NMJ stability|inhibition of neuromuscular junction development|inhibition of neuromuscular junction organization|inhibition of neuromuscular junction stability|negative regulation of NMJ stability|negative regulation of neuromuscular junction organization|negative regulation of neuromuscular junction stability http://purl.obolibrary.org/obo/GO_1904397 GO:1904396 biolink:BiologicalProcess regulation of neuromuscular junction development Any process that modulates the frequency, rate or extent of neuromuscular junction development. go.json regulation of NMJ stability|regulation of neuromuscular junction organization|regulation of neuromuscular junction stability http://purl.obolibrary.org/obo/GO_1904396 GO:1904395 biolink:BiologicalProcess positive regulation of skeletal muscle acetylcholine-gated channel clustering Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. go.json activation of skeletal muscle AChR clustering|activation of skeletal muscle acetylcholine-gated channel clustering|activation of skeletal muscle nicotinic acetylcholine receptor clustering|positive regulation of skeletal muscle AChR clustering|positive regulation of skeletal muscle nicotinic acetylcholine receptor clustering|up regulation of skeletal muscle AChR clustering|up regulation of skeletal muscle acetylcholine-gated channel clustering|up regulation of skeletal muscle nicotinic acetylcholine receptor clustering|up-regulation of skeletal muscle AChR clustering|up-regulation of skeletal muscle acetylcholine-gated channel clustering|up-regulation of skeletal muscle nicotinic acetylcholine receptor clustering|upregulation of skeletal muscle AChR clustering|upregulation of skeletal muscle acetylcholine-gated channel clustering|upregulation of skeletal muscle nicotinic acetylcholine receptor clustering http://purl.obolibrary.org/obo/GO_1904395 GO:1904394 biolink:BiologicalProcess negative regulation of skeletal muscle acetylcholine-gated channel clustering Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. go.json down regulation of skeletal muscle AChR clustering|down regulation of skeletal muscle acetylcholine-gated channel clustering|down regulation of skeletal muscle nicotinic acetylcholine receptor clustering|down-regulation of skeletal muscle AChR clustering|down-regulation of skeletal muscle acetylcholine-gated channel clustering|down-regulation of skeletal muscle nicotinic acetylcholine receptor clustering|downregulation of skeletal muscle AChR clustering|downregulation of skeletal muscle acetylcholine-gated channel clustering|downregulation of skeletal muscle nicotinic acetylcholine receptor clustering|inhibition of skeletal muscle AChR clustering|inhibition of skeletal muscle acetylcholine-gated channel clustering|inhibition of skeletal muscle nicotinic acetylcholine receptor clustering|negative regulation of skeletal muscle AChR clustering|negative regulation of skeletal muscle nicotinic acetylcholine receptor clustering http://purl.obolibrary.org/obo/GO_1904394 GO:1904393 biolink:BiologicalProcess regulation of skeletal muscle acetylcholine-gated channel clustering Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. go.json regulation of skeletal muscle AChR clustering|regulation of skeletal muscle nicotinic acetylcholine receptor clustering http://purl.obolibrary.org/obo/GO_1904393 GO:1904392 biolink:BiologicalProcess cellular response to ciliary neurotrophic factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus. go.json http://purl.obolibrary.org/obo/GO_1904392 GO:1904391 biolink:BiologicalProcess response to ciliary neurotrophic factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus. go.json http://purl.obolibrary.org/obo/GO_1904391 GO:1904390 biolink:BiologicalProcess cone retinal bipolar cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell. go.json cone bipolar cell differentiation|retinal cone bipolar cell differentiation http://purl.obolibrary.org/obo/GO_1904390 GO:0052722 biolink:MolecularActivity fatty acid in-chain hydroxylase activity Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O. MetaCyc:RXN-12186|RHEA:45084 go.json http://purl.obolibrary.org/obo/GO_0052722 GO:0003799 biolink:MolecularActivity obsolete antifungal peptide activity OBSOLETE. Inhibits the growth of, or directly kills, fungal cells. go.json antifungal peptide activity True http://purl.obolibrary.org/obo/GO_0003799 GO:0003798 biolink:MolecularActivity obsolete male-specific antibacterial peptide activity OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males. go.json male-specific antibacterial peptide activity True http://purl.obolibrary.org/obo/GO_0003798 GO:0052721 biolink:BiologicalProcess obsolete regulation of apurinic/apyrimidinic endodeoxyribonuclease activity OBSOLETE. Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. go.json regulation of AP endodeoxyribonuclease activity|regulation of abasic endodeoxyribonuclease activity|regulation of apurinic endodeoxyribonuclease activity|regulation of apyrimidinic endodeoxyribonuclease activity True http://purl.obolibrary.org/obo/GO_0052721 GO:0052720 biolink:MolecularActivity class II DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. go.json class II DNA-(apurinic or apyrimidinic site) lyase activity http://purl.obolibrary.org/obo/GO_0052720 GO:0052726 biolink:MolecularActivity inositol-1,3,4-trisphosphate 5-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+. EC:2.7.1.159|KEGG_REACTION:R03428|MetaCyc:2.7.1.139-RXN|RHEA:13253|Reactome:R-HSA-1855172|Reactome:R-HSA-994140 go.json 1D-myo-inositol-trisphosphate 5-kinase activity|ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity|IP3 5-kinase activity|Ins(1,3,4)P3 5-kinase activity|inositol 1,3,4-trisphosphate 5-kinase activity|inositol-trisphosphate 5-kinase activity|ins(1,3,4)P(3) 5-kinase activity http://purl.obolibrary.org/obo/GO_0052726 GO:0003795 biolink:MolecularActivity obsolete antimicrobial peptide activity OBSOLETE. Inhibits the growth of, or directly kills, microbial cells. go.json antimicrobial peptide activity True http://purl.obolibrary.org/obo/GO_0003795 GO:0052725 biolink:MolecularActivity inositol-1,3,4-trisphosphate 6-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+. EC:2.7.1.159|MetaCyc:2.7.1.133-RXN|RHEA:20940|Reactome:R-HSA-1855197|Reactome:R-HSA-2267372 go.json 1D-myo-inositol-trisphosphate 6-kinase activity|ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity|IP3 6-kinase activity|Ins(1,3,4)P3 6-kinase activity|inositol 1,3,4-trisphosphate 6-kinase activity|inositol-trisphosphate 6-kinase activity|ins(1,3,4)P(3) 6-kinase activity http://purl.obolibrary.org/obo/GO_0052725 GO:0003794 biolink:MolecularActivity obsolete acute-phase response protein activity OBSOLETE. (Was not defined before being made obsolete). go.json acute-phase response protein activity True http://purl.obolibrary.org/obo/GO_0003794 GO:0052724 biolink:MolecularActivity inositol hexakisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate. EC:2.7.4.21|MetaCyc:RXN-10971 go.json http://purl.obolibrary.org/obo/GO_0052724 GO:0003797 biolink:MolecularActivity obsolete antibacterial peptide activity OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells. go.json antibacterial peptide activity True http://purl.obolibrary.org/obo/GO_0003797 GO:0052723 biolink:MolecularActivity inositol hexakisphosphate 1-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate. EC:2.7.4.21|KEGG_REACTION:R05799|MetaCyc:RXN-10972|RHEA:37459 go.json http://purl.obolibrary.org/obo/GO_0052723 GO:0003796 biolink:MolecularActivity lysozyme activity Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. EC:3.2.1.17|MetaCyc:3.2.1.17-RXN|Reactome:R-HSA-8862320 go.json 1,4-N-acetylmuramidase activity|L-7001|N,O-diacetylmuramidase activity|PR1-lysozyme|globulin G|globulin G1|lysozyme g|mucopeptide N-acetylmuramoylhydrolase activity|mucopeptide glucohydrolase activity|muramidase activity|peptidoglycan N-acetylmuramoylhydrolase activity http://purl.obolibrary.org/obo/GO_0003796 GO:0003791 biolink:MolecularActivity obsolete membrane associated actin binding OBSOLETE. (Was not defined before being made obsolete). go.json membrane associated actin binding True http://purl.obolibrary.org/obo/GO_0003791 GO:0052729 biolink:MolecularActivity dimethylglycine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine. EC:2.1.1.157|EC:2.1.1.161|EC:2.1.1.162|KEGG_REACTION:R07244|MetaCyc:RXN-9680|RHEA:10072 go.json ApDMT|S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0052729 GO:0003790 biolink:MolecularActivity obsolete actin modulating activity OBSOLETE. (Was not defined before being made obsolete). go.json actin modulating activity True http://purl.obolibrary.org/obo/GO_0003790 GO:0052728 biolink:MolecularActivity capsorubin synthase activity Catalysis of the reaction: violaxanthin = capsorubin. EC:5.3.99.8|MetaCyc:RXN-7946|RHEA:21752 go.json CCS|capsanthin-capsorubin synthase activity|ketoxanthophyll synthase activity|violaxanthin-capsorubin isomerase (ketone-forming) activity http://purl.obolibrary.org/obo/GO_0052728 GO:0003793 biolink:MolecularActivity obsolete defense/immunity protein activity OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease. go.json defence/immunity protein activity|defense/immunity protein activity True http://purl.obolibrary.org/obo/GO_0003793 GO:0052727 biolink:MolecularActivity capsanthin synthase activity Catalysis of the reaction: antheraxanthin = capsanthin. EC:5.3.99.8|MetaCyc:RXN-7947|RHEA:17373 go.json CCS|capsanthin-capsorubin synthase activity|ketoxanthophyll synthase activity http://purl.obolibrary.org/obo/GO_0052727 GO:0003792 biolink:MolecularActivity obsolete regulation of actin thin filament length activity OBSOLETE. (Was not defined before being made obsolete). go.json regulation of actin thin filament length activity True http://purl.obolibrary.org/obo/GO_0003792 GO:0052733 biolink:MolecularActivity quinate 3-dehydrogenase (NADP+) activity Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+. EC:1.1.1.282|KEGG_REACTION:R06846|RHEA:18425 go.json quinate:NADP 3-oxidoreductase activity|quinate:NADP(+) 3-oxidoreductase activity|quinic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052733 GO:0052732 biolink:MolecularActivity phosphoethanolamine phosphatase activity Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. EC:3.1.3.75|KEGG_REACTION:R06870|MetaCyc:RXN-7948|RHEA:16089|Reactome:R-HSA-1483096 go.json 3X11A|PHOSPHO1|phosphoethanolamine phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0052732 GO:0052731 biolink:MolecularActivity phosphocholine phosphatase activity Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. EC:3.1.3.75|KEGG_REACTION:R06871|MetaCyc:RXN-5647|RHEA:10492|Reactome:R-HSA-1483159 go.json 3X11A|PHOSPHO1|phosphoethanolamine phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0052731 GO:0052730 biolink:MolecularActivity sarcosine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine. EC:2.1.1.156|EC:2.1.1.157|EC:2.1.1.162|KEGG_REACTION:R07243|MetaCyc:RXN-9679|RHEA:15453 go.json S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity|SDMT http://purl.obolibrary.org/obo/GO_0052730 GO:0052737 biolink:MolecularActivity pyruvate dehydrogenase (quinone) activity Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2. EC:1.2.5.1|KEGG_REACTION:R03145|MetaCyc:RXN-11496|RHEA:27405 go.json pyruvate dehydrogenase activity|pyruvate:ubiquinone oxidoreductase activity|pyruvate:ubiquinone-8-oxidoreductase activity|pyruvic dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052737 GO:0052736 biolink:MolecularActivity beta-glucanase activity Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds. go.json beta-D-glucanase activity http://purl.obolibrary.org/obo/GO_0052736 GO:0052735 biolink:MolecularActivity tRNA (cytidine-3-)-methyltransferase activity Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = an N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine. RHEA:60908 go.json S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity|tRNA (cytosine 3)-methyltransferase activity|tRNA (cytosine-3-)-methyltransferase activity|tRNA cytosine 3-methyltransferase activity|tRNA cytosine-3-methyltransferase activity|transfer ribonucleate cytosine 3-methyltransferase activity http://purl.obolibrary.org/obo/GO_0052735 GO:0052734 biolink:MolecularActivity shikimate 3-dehydrogenase (NAD+) activity Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+. EC:1.1.1.282|KEGG_REACTION:R06847|RHEA:17741 go.json 3-dehydroshikimate reductase activity|3-dehydroshikimic reductase activity|DHS reductase activity|dehydroshikimic reductase activity|shikimate oxidoreductase activity|shikimate:NAD(P)(+) 3-oxidoreductase activity|shikimate:NAD(P)(+) oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052734 GO:0052739 biolink:MolecularActivity phosphatidylserine 1-acylhydrolase activity Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid. EC:3.1.1.32|KEGG_REACTION:R04034|Reactome:R-HSA-8869425 go.json phosphatidylserine-specific phospholipase A1 activity http://purl.obolibrary.org/obo/GO_0052739 GO:0052738 biolink:MolecularActivity oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound. EC:1.2.5.- go.json http://purl.obolibrary.org/obo/GO_0052738 GO:0003777 biolink:MolecularActivity microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. Reactome:R-HSA-177479|Reactome:R-HSA-265160|Reactome:R-HSA-9610627 go.json ATP-dependent microtubule motor activity|axonemal motor activity|dynein|dynein ATPase activity|kinesin|kinesin motor activity|kinetochore motor activity http://purl.obolibrary.org/obo/GO_0003777 GO:0052744 biolink:MolecularActivity phosphatidylinositol monophosphate phosphatase activity Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate. go.json http://purl.obolibrary.org/obo/GO_0052744 GO:0003776 biolink:MolecularActivity obsolete muscle motor activity OBSOLETE. (Was not defined before being made obsolete). go.json muscle motor activity True http://purl.obolibrary.org/obo/GO_0003776 GO:0052743 biolink:MolecularActivity inositol tetrakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. go.json http://purl.obolibrary.org/obo/GO_0052743 GO:0052742 biolink:MolecularActivity phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. Reactome:R-HSA-1675773 go.json 1-phosphatidylinositol kinase activity http://purl.obolibrary.org/obo/GO_0052742 GO:0003779 biolink:MolecularActivity actin binding Binding to monomeric or multimeric forms of actin, including actin filaments. go.json membrane associated actin binding http://purl.obolibrary.org/obo/GO_0003779 GO:0052741 biolink:MolecularActivity (R)-limonene 6-monooxygenase activity Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+. EC:1.14.14.53|KEGG_REACTION:R06119|MetaCyc:1.14.13.84-RXN|RHEA:18957 go.json (+)-limonene 6-monooxygenase activity|(+)-limonene-6-hydroxylase activity|(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity http://purl.obolibrary.org/obo/GO_0052741 GO:0003778 biolink:MolecularActivity obsolete dynactin motor OBSOLETE. (Was not defined before being made obsolete). go.json dynactin motor True http://purl.obolibrary.org/obo/GO_0003778 GO:0052748 biolink:MolecularActivity baicalin beta-D-glucuronidase activity Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate. EC:3.2.1.167|KEGG_REACTION:R09533|MetaCyc:RXN-11760|RHEA:28130 go.json 5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity|baicalinase activity http://purl.obolibrary.org/obo/GO_0052748 GO:0003773 biolink:MolecularActivity obsolete heat shock protein activity OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones. go.json heat shock protein activity True http://purl.obolibrary.org/obo/GO_0003773 GO:0003772 biolink:MolecularActivity obsolete co-chaperonin activity OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity. go.json co-chaperonin activity True http://purl.obolibrary.org/obo/GO_0003772 GO:0052747 biolink:MolecularActivity sinapyl alcohol dehydrogenase activity Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+. EC:1.1.1.195|KEGG_REACTION:R03918|MetaCyc:RXN-1125|RHEA:45704 go.json sinapyl-alcohol dehydrogenase activity|sinapyl-alcohol:NADP+ oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052747 GO:0003775 biolink:MolecularActivity obsolete axonemal motor activity OBSOLETE. (Was not defined before being made obsolete). go.json axonemal motor activity True http://purl.obolibrary.org/obo/GO_0003775 GO:0052746 biolink:BiologicalProcess obsolete inositol phosphorylation OBSOLETE. The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms. go.json inositol and derivative phosphorylation|myo-inositol and derivative phosphorylation|myo-inositol phosphorylation True http://purl.obolibrary.org/obo/GO_0052746 GO:0003774 biolink:MolecularActivity cytoskeletal motor activity Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). Reactome:R-HSA-1861595 go.json motor activity http://purl.obolibrary.org/obo/GO_0003774 goslim_candida|goslim_generic|goslim_pir|goslim_plant|prokaryote_subset GO:0052745 biolink:MolecularActivity inositol phosphate phosphatase activity Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. go.json http://purl.obolibrary.org/obo/GO_0052745 GO:0003771 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003771 GO:0052749 biolink:MolecularActivity glucose-6-phosphate dehydrogenase (coenzyme F420) activity Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420. EC:1.1.98.2|KEGG_REACTION:R09550|MetaCyc:RXN-11283|RHEA:27294 go.json D-glucose-6-phosphate:F420 1-oxidoreductase activity|F420-dependent glucose-6-phosphate dehydrogenase activity|coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0052749 GO:0003770 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003770 GO:0052740 biolink:MolecularActivity 1-acyl-2-lysophosphatidylserine acylhydrolase activity Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate. EC:3.1.1.32 go.json phosphatidylserine-specific phospholipase A1 activity http://purl.obolibrary.org/obo/GO_0052740 GO:0003788 biolink:MolecularActivity obsolete actin monomer sequestering activity OBSOLETE. (Was not defined before being made obsolete). go.json actin monomer sequestering activity True http://purl.obolibrary.org/obo/GO_0003788 GO:0052755 biolink:MolecularActivity reduced coenzyme F420:quinone oxidoreductase activity Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone. go.json F420H2-dependent quinone oxidoreductase activity|F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity|F420H2:quinone oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052755 GO:0052754 biolink:MolecularActivity GTP:coenzyme F420 guanyltransferase activity Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate. go.json GTP:coenzyme F420 guanylyltransferase activity|coenzyme F390-G synthetase activity http://purl.obolibrary.org/obo/GO_0052754 GO:0003787 biolink:MolecularActivity obsolete actin depolymerizing activity OBSOLETE. (Was not defined before being made obsolete). go.json actin depolymerizing activity True http://purl.obolibrary.org/obo/GO_0003787 GO:0052753 biolink:MolecularActivity propan-2-ol:coenzyme F420 oxidoreductase activity Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420. go.json F420-dependent propan-2-ol dehydrogenase activity|F420-dependent secondary alcohol dehydrogenase activity|isopropanol:coenzyme F420 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052753 GO:0052752 biolink:MolecularActivity reduced coenzyme F420:heterodisulfide oxidoreductase activity Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH. go.json F420-dependent heterodisulfide oxidoreductase activity|F420H2:heterodisulfide oxidoreductase activity|coenzyme F420-dependent heterodisulfide oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052752 GO:0003789 biolink:MolecularActivity actin filament severing activity Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments. go.json actin depolymerizing activity http://purl.obolibrary.org/obo/GO_0003789 GO:0052759 biolink:MolecularActivity coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction. EC:1.3.99.-|UM-BBD_reactionID:r1066 go.json coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity http://purl.obolibrary.org/obo/GO_0052759 GO:0003784 biolink:MolecularActivity obsolete barbed-end actin capping/severing activity OBSOLETE. (Was not defined before being made obsolete). go.json barbed-end actin capping/severing activity True http://purl.obolibrary.org/obo/GO_0003784 GO:0052758 biolink:MolecularActivity coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction. EC:1.3.99.-|UM-BBD_reactionID:r1065 go.json TNP reductase activity|coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity http://purl.obolibrary.org/obo/GO_0052758 GO:0003783 biolink:MolecularActivity obsolete barbed-end actin capping activity OBSOLETE. (Was not defined before being made obsolete). go.json barbed-end actin capping activity True http://purl.obolibrary.org/obo/GO_0003783 GO:0052757 biolink:MolecularActivity chondroitin hydrolase activity Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]. go.json chondroitin endo-beta-galactosaminidase activity http://purl.obolibrary.org/obo/GO_0052757 GO:0003786 biolink:MolecularActivity actin lateral binding Binding to an actin filament along its length. go.json http://purl.obolibrary.org/obo/GO_0003786 GO:0052756 biolink:MolecularActivity chitobiose phosphorylase activity Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units. go.json http://purl.obolibrary.org/obo/GO_0052756 GO:0003785 biolink:MolecularActivity actin monomer binding Binding to monomeric actin, also known as G-actin. go.json G actin binding http://purl.obolibrary.org/obo/GO_0003785 GO:0003780 biolink:MolecularActivity obsolete actin cross-linking activity OBSOLETE. Interacting selectively with two actin filaments to anchor them together. go.json actin cross-linking activity True http://purl.obolibrary.org/obo/GO_0003780 GO:0003782 biolink:MolecularActivity obsolete F-actin capping activity OBSOLETE. (Was not defined before being made obsolete). go.json F-actin capping activity True http://purl.obolibrary.org/obo/GO_0003782 GO:0003781 biolink:MolecularActivity obsolete actin bundling activity OBSOLETE. (Was not defined before being made obsolete). go.json actin bundling activity True http://purl.obolibrary.org/obo/GO_0003781 GO:0052751 biolink:MolecularActivity GDP-mannose hydrolase activity Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate. go.json GDP-mannose pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0052751 GO:0052750 biolink:MolecularActivity reactive-black-5:hydrogen-peroxide oxidoreductase activity Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O. EC:1.11.1.16|KEGG_REACTION:R07612|MetaCyc:RXN-8666|RHEA:22396 go.json versatile peroxidase activity http://purl.obolibrary.org/obo/GO_0052750 GO:0003755 biolink:MolecularActivity peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). EC:5.2.1.8|MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN|RHEA:16237|Reactome:R-HSA-2022073|Reactome:R-HSA-9626816 go.json FK506-sensitive peptidyl-prolyl cis-trans isomerase|PPIase activity|cis-trans proline isomerase activity|cyclophilin activity|cyclophilin-type peptidyl-prolyl cis-trans isomerase activity|immunophilin|juglone-sensitive cis-trans proline isomerase activity|juglone-sensitive peptidyl-prolyl cis-trans isomerase activity|parvulin|peptide bond isomerase activity|peptidyl-prolyl isomerase B reaction|peptidylproline cis-trans-isomerase activity|peptidylprolyl cis-trans isomerase activity|peptidylprolyl isomerase activity|rotamase activity http://purl.obolibrary.org/obo/GO_0003755 GO:0052766 biolink:MolecularActivity mannoside alpha-1,4-mannosidase activity Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. go.json alpha-1,4-exomannosidase activity|alpha-1,4-mannosidase activity|mannoside alpha-1,4-exomannosidase activity|mannoside exo-alpha-1,4-mannosidase activity http://purl.obolibrary.org/obo/GO_0052766 GO:0052765 biolink:MolecularActivity reduced coenzyme F420 oxidase activity Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O. go.json F420H2 oxidase activity|F420H2:oxygen oxidoreductase activity|coenzyme F420H2 oxidase activity http://purl.obolibrary.org/obo/GO_0052765 GO:0003754 biolink:MolecularActivity obsolete chaperone activity OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function. go.json chaperone activity True http://purl.obolibrary.org/obo/GO_0003754 GO:0052764 biolink:MolecularActivity exo-oligoalginate lyase activity Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. EC:4.2.2.26 go.json http://purl.obolibrary.org/obo/GO_0052764 GO:0003757 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003757 GO:0003756 biolink:MolecularActivity protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. EC:5.3.4.1|MetaCyc:5.3.4.1-RXN|Reactome:R-HSA-8950113|Reactome:R-HSA-8950183|Reactome:R-HSA-8950456 go.json S-S rearrangase activity|disulphide bond formation|protein cysteine-thiol oxidation|protein disulfide-isomerase|protein disulphide isomerase activity|protein thiol-disulfide exchange|protein thiol-disulphide exchange http://purl.obolibrary.org/obo/GO_0003756 GO:0052763 biolink:MolecularActivity ulvan lyase activity Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end. go.json http://purl.obolibrary.org/obo/GO_0052763 GO:0003751 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003751 GO:0052769 biolink:MolecularActivity beta-6-sulfate-N-acetylglucosaminidase activity Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative. go.json beta-6-SO3-N-acetylglucosaminidase activity|exosulfoglycosidase activity|sulfoglycosidase activity|sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity http://purl.obolibrary.org/obo/GO_0052769 GO:0003750 biolink:MolecularActivity obsolete cell cycle regulator OBSOLETE. (Was not defined before being made obsolete). go.json cell cycle regulator True http://purl.obolibrary.org/obo/GO_0003750 GO:0003753 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003753 GO:0052768 biolink:MolecularActivity mannosyl-oligosaccharide 1,3-alpha-mannosidase activity Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide. go.json 1,3-alpha-mannosidase activity|1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|alpha-1,3-mannosidase activity|alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity http://purl.obolibrary.org/obo/GO_0052768 GO:0052767 biolink:MolecularActivity mannosyl-oligosaccharide 1,6-alpha-mannosidase activity Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide. go.json 1,6-alpha-mannosidase activity|1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|alpha-1,6-mannosidase activity|alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity http://purl.obolibrary.org/obo/GO_0052767 GO:0003752 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003752 GO:0052762 biolink:MolecularActivity gellan lyase activity Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha). EC:4.2.2.25|MetaCyc:RXN-12269 go.json http://purl.obolibrary.org/obo/GO_0052762 GO:0003759 biolink:MolecularActivity obsolete glycoprotein-specific chaperone activity OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins. go.json glycoprotein-specific chaperone activity True http://purl.obolibrary.org/obo/GO_0003759 GO:0003758 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003758 GO:0052761 biolink:MolecularActivity exo-1,4-beta-D-glucosaminidase activity Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units. EC:3.2.1.165|KEGG_REACTION:R08715|MetaCyc:3.2.1.165-RXN go.json chitosan exo-1,4-beta-D-glucosaminidase activity|chitosan glucosaminohydrolase activity|exo-beta-D-glucosaminidase activity|exochitosanase activity http://purl.obolibrary.org/obo/GO_0052761 GO:0052760 biolink:MolecularActivity coenzyme F420-dependent 2,4-dinitrophenol reductase activity Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction. EC:1.3.99.-|UM-BBD_reactionID:r1071 go.json DNP reductase activity|coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity http://purl.obolibrary.org/obo/GO_0052760 GO:0052777 biolink:BiologicalProcess diacetylchitobiose catabolic process The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products. go.json diacetylchitobiose catabolism http://purl.obolibrary.org/obo/GO_0052777 GO:0003766 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003766 GO:0052776 biolink:BiologicalProcess diacetylchitobiose catabolic process to glucosamine and acetate The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate. go.json http://purl.obolibrary.org/obo/GO_0052776 GO:0003765 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003765 GO:0052775 biolink:MolecularActivity endo-1,3-alpha-L-rhamnosidase activity Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain. go.json endo-(1,3)-alpha-L-rhamnosidase activity|endo-(1->3)-alpha-L-rhamnosidase activity|endorhamnosidase activity http://purl.obolibrary.org/obo/GO_0052775 GO:0003768 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003768 GO:0003767 biolink:MolecularActivity obsolete co-chaperone activity OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity. go.json co-chaperone activity True http://purl.obolibrary.org/obo/GO_0003767 GO:0052774 biolink:MolecularActivity glucosyl-N-acetylglucosamine glucosaminidase activity Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine. go.json http://purl.obolibrary.org/obo/GO_0052774 GO:0003762 biolink:MolecularActivity obsolete histone-specific chaperone activity OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function. go.json histone-specific chaperone activity|nucleosome assembly chaperone True http://purl.obolibrary.org/obo/GO_0003762 GO:0003761 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003761 GO:0003764 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003764 GO:0052779 biolink:BiologicalProcess amino disaccharide metabolic process The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions. go.json http://purl.obolibrary.org/obo/GO_0052779 GO:0052778 biolink:BiologicalProcess diacetylchitobiose metabolic process The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose. go.json diacetylchitobiose metabolism http://purl.obolibrary.org/obo/GO_0052778 GO:0003763 biolink:MolecularActivity obsolete chaperonin ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. go.json chaperonin|chaperonin ATPase activity True http://purl.obolibrary.org/obo/GO_0003763 GO:0003760 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003760 GO:0052773 biolink:MolecularActivity diacetylchitobiose deacetylase activity Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). MetaCyc:RXN-12543 go.json N,N'-diacetylchitobiose deacetylase (nonreducing end) http://purl.obolibrary.org/obo/GO_0052773 GO:0003769 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003769 GO:0052772 biolink:MolecularActivity brefeldin A esterase activity Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone. go.json BFA esterase activity|brefeldin A hydrolase activity http://purl.obolibrary.org/obo/GO_0052772 GO:0052771 biolink:MolecularActivity coenzyme F390-G hydrolase activity Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420. go.json 8-hydroxyguanylylated-coenzyme F420 hydrolase activity http://purl.obolibrary.org/obo/GO_0052771 GO:0052770 biolink:MolecularActivity coenzyme F390-A hydrolase activity Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420. go.json 8-hydroxyadenylylated-coenzyme F420 hydrolase activity http://purl.obolibrary.org/obo/GO_0052770 GO:0003733 biolink:MolecularActivity obsolete ribonucleoprotein OBSOLETE. (Was not defined before being made obsolete). go.json ribonucleoprotein True http://purl.obolibrary.org/obo/GO_0003733 GO:0052788 biolink:MolecularActivity d-4,5 unsaturated beta-glucuronyl hydrolase activity Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue. go.json unsaturated beta-glucuronyl hydrolase activity http://purl.obolibrary.org/obo/GO_0052788 GO:0003732 biolink:MolecularActivity obsolete snRNA cap binding OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule. go.json snRNA cap binding True http://purl.obolibrary.org/obo/GO_0003732 GO:0052787 biolink:BiologicalProcess alpha-linked polysaccharide catabolism to maltopentaose The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose. go.json alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose|maltopentaose-forming alpha-amylase activity http://purl.obolibrary.org/obo/GO_0052787 GO:0003735 biolink:MolecularActivity structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome. go.json ribosomal RNA|ribosomal protein http://purl.obolibrary.org/obo/GO_0003735 goslim_chembl|goslim_drosophila|goslim_metagenomics|goslim_yeast GO:0052786 biolink:BiologicalProcess alpha-linked polysaccharide catabolism to maltotriose The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose. go.json alpha-amylase-mediated polysaccharide catabolism, producing maltotriose|maltotriose-forming alpha-amylase activity http://purl.obolibrary.org/obo/GO_0052786 GO:0003734 biolink:MolecularActivity obsolete small nuclear ribonucleoprotein OBSOLETE. (Was not defined before being made obsolete). go.json small nuclear ribonucleoprotein|snRNP True http://purl.obolibrary.org/obo/GO_0003734 GO:0052785 biolink:BiologicalProcess cellulose catabolism by endo-processive cellulases The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments. go.json endo-processive cellulase activity http://purl.obolibrary.org/obo/GO_0052785 GO:0003731 biolink:MolecularActivity obsolete mRNA cap binding OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript. go.json mRNA cap binding True http://purl.obolibrary.org/obo/GO_0003731 GO:0052789 biolink:MolecularActivity mannan 1,3-beta-mannosidase activity Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose. go.json 1,3-beta-D-mannan mannanohydrolase activity|beta-1,3-mannan 3-mannanohydrolase activity|exo-1,3-beta-mannanase activity|exo-1,3-mannanase activity|exo-beta-1,3-mannase activity http://purl.obolibrary.org/obo/GO_0052789 GO:0003730 biolink:MolecularActivity mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule. go.json mRNA 3' UTR binding http://purl.obolibrary.org/obo/GO_0003730 GO:0062110 biolink:BiologicalProcess negative regulation of DNA recombinase disassembly Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0062110 GO:0062112 biolink:BiologicalProcess fatty acid primary amide biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid primary amide. go.json FAPA biosynthesis|FAPA biosynthetic process|fatty acid amide biosynthesis http://purl.obolibrary.org/obo/GO_0062112 GO:0062111 biolink:BiologicalProcess zinc ion import into organelle The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle. go.json http://purl.obolibrary.org/obo/GO_0062111 GO:0062113 biolink:CellularComponent early phagosome lumen The volume enclosed by the membrane of an eary phagosome. go.json early phagocytic vesicle lumen http://purl.obolibrary.org/obo/GO_0062113 GO:0062116 biolink:CellularComponent phenyloplast A chloroplast-derived plastid in which the solid form of phenol is stored. go.json http://purl.obolibrary.org/obo/GO_0062116 GO:0062119 biolink:CellularComponent LinE complex A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins. go.json http://purl.obolibrary.org/obo/GO_0062119 GO:0052780 biolink:BiologicalProcess chitobiose metabolic process The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine. go.json http://purl.obolibrary.org/obo/GO_0052780 GO:0052784 biolink:BiologicalProcess reuteran biosynthetic process The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages. go.json reuteransucrase-mediated reuteran biosynthesis http://purl.obolibrary.org/obo/GO_0052784 GO:0003737 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003737 GO:0003736 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003736 GO:0052783 biolink:BiologicalProcess reuteran metabolic process The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages. go.json http://purl.obolibrary.org/obo/GO_0052783 GO:0052782 biolink:BiologicalProcess amino disaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions. go.json http://purl.obolibrary.org/obo/GO_0052782 GO:0003739 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003739 GO:0052781 biolink:BiologicalProcess chitobiose catabolic process The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine. go.json http://purl.obolibrary.org/obo/GO_0052781 GO:0003738 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003738 GO:0003744 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003744 GO:0052799 biolink:BiologicalProcess coenzyme F420-dependent bicyclic nitroimidazole catabolic process The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates. go.json coenzyme F420-dependent nitroimidazole breakdown|coenzyme F420-dependent nitroimidazole catabolism|coenzyme F420-dependent nitroimidazole reduction|coenzyme F420-dependent nitroreductase activity http://purl.obolibrary.org/obo/GO_0052799 GO:0003743 biolink:MolecularActivity translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. Reactome:R-HSA-72621|Reactome:R-HSA-72697|Reactome:R-HSA-72722 go.json http://purl.obolibrary.org/obo/GO_0003743 GO:0052798 biolink:MolecularActivity beta-galactoside alpha-2,3-sialyltransferase activity Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor. go.json trans-sialidase activity http://purl.obolibrary.org/obo/GO_0052798 GO:0003746 biolink:MolecularActivity translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome. Reactome:R-HSA-192704|Reactome:R-HSA-192841 go.json http://purl.obolibrary.org/obo/GO_0003746 GO:0052797 biolink:MolecularActivity 4-O-methyl-glucuronoyl methylesterase activity Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]. go.json glucuronoyl esterase activity http://purl.obolibrary.org/obo/GO_0052797 GO:0003745 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003745 GO:0052796 biolink:MolecularActivity exo-alpha-(2->8)-sialidase activity Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. EC:3.2.1.18 go.json exo-alpha-(2,8)-sialidase activity|exo-alpha-2,8-sialidase activity http://purl.obolibrary.org/obo/GO_0052796 GO:0003740 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003740 GO:1904309 biolink:BiologicalProcess response to cordycepin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus. go.json response to 3'-deoxyadenosine http://purl.obolibrary.org/obo/GO_1904309 GO:0003742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003742 GO:1904308 biolink:BiologicalProcess cellular response to desipramine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904308 GO:0003741 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003741 GO:1904307 biolink:BiologicalProcess response to desipramine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus. go.json http://purl.obolibrary.org/obo/GO_1904307 GO:1904306 biolink:BiologicalProcess positive regulation of gastro-intestinal system smooth muscle contraction Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. go.json activation of gastro-intestinal system smooth muscle contraction|up regulation of gastro-intestinal system smooth muscle contraction|up-regulation of gastro-intestinal system smooth muscle contraction|upregulation of gastro-intestinal system smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904306 GO:1904305 biolink:BiologicalProcess negative regulation of gastro-intestinal system smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. go.json down regulation of gastro-intestinal system smooth muscle contraction|down-regulation of gastro-intestinal system smooth muscle contraction|downregulation of gastro-intestinal system smooth muscle contraction|inhibition of gastro-intestinal system smooth muscle contraction http://purl.obolibrary.org/obo/GO_1904305 GO:1904304 biolink:BiologicalProcess regulation of gastro-intestinal system smooth muscle contraction Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. go.json http://purl.obolibrary.org/obo/GO_1904304 GO:1904303 biolink:BiologicalProcess positive regulation of maternal process involved in parturition Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition. go.json activation of maternal process involved in parturition|up regulation of maternal process involved in parturition|up-regulation of maternal process involved in parturition|upregulation of maternal process involved in parturition http://purl.obolibrary.org/obo/GO_1904303 GO:1904302 biolink:BiologicalProcess negative regulation of maternal process involved in parturition Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition. go.json down regulation of maternal process involved in parturition|down-regulation of maternal process involved in parturition|downregulation of maternal process involved in parturition|inhibition of maternal process involved in parturition http://purl.obolibrary.org/obo/GO_1904302 GO:0062101 biolink:MolecularActivity peptidyl-aspartic acid 3-dioxygenase activity Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2. EC:1.14.11.16|MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN|RESID:AA0026|RHEA:11508|Reactome:R-HSA-9631355 go.json aspartate beta-hydroxylase activity|aspartyl/asparaginyl beta-hydroxylase activity|aspartylpeptide beta-dioxygenase activity|peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|peptide-aspartate beta-dioxygenase activity http://purl.obolibrary.org/obo/GO_0062101 GO:1904301 biolink:BiologicalProcess regulation of maternal process involved in parturition Any process that modulates the frequency, rate or extent of maternal process involved in parturition. go.json http://purl.obolibrary.org/obo/GO_1904301 GO:0062100 biolink:BiologicalProcess positive regulation of programmed necrotic cell death Any process that increases the frequency, rate or extent of programmed necrotic cell death. go.json http://purl.obolibrary.org/obo/GO_0062100 GO:1904300 biolink:BiologicalProcess positive regulation of transcytosis Any process that activates or increases the frequency, rate or extent of transcytosis. go.json activation of transcytosis|up regulation of transcytosis|up-regulation of transcytosis|upregulation of transcytosis http://purl.obolibrary.org/obo/GO_1904300 GO:1904310 biolink:BiologicalProcess cellular response to cordycepin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus. go.json cellular response to 3'-deoxyadenosine http://purl.obolibrary.org/obo/GO_1904310 GO:0062103 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0062103 GO:0062102 biolink:BiologicalProcess female germline stem cell symmetric division Division of a female germline stem cell to produce two germline stem cells of the same type as the parent. go.json http://purl.obolibrary.org/obo/GO_0062102 GO:0062105 biolink:MolecularActivity RNA 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide. RHEA:58956 go.json http://purl.obolibrary.org/obo/GO_0062105 GO:0062104 biolink:MolecularActivity pumilio-response element binding Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA. go.json PRE binding http://purl.obolibrary.org/obo/GO_0062104 GO:0062107 biolink:BiologicalProcess regulation of protein localization to non-growing cell tip Any process that modulates the frequency, rate or extent of protein localization to a non-growing cell tip. go.json http://purl.obolibrary.org/obo/GO_0062107 GO:0062109 biolink:BiologicalProcess regulation of DNA recombinase disassembly Any process that modulates the rate, frequency or extent of DNA recombinase disassembly, the disaggregation of a DNA recombinase complex into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0062109 GO:0062108 biolink:BiologicalProcess negative regulation of protein localization to non-growing cell tip Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a non-growing cell tip. go.json http://purl.obolibrary.org/obo/GO_0062108 GO:0052791 biolink:MolecularActivity 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain. go.json 2-keto-3-deoxynononic acid sialidase activity http://purl.obolibrary.org/obo/GO_0052791 GO:0052790 biolink:MolecularActivity chitooligosaccharide deacetylase activity Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions. EC:3.5.1.- go.json http://purl.obolibrary.org/obo/GO_0052790 GO:0003748 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003748 GO:0052795 biolink:MolecularActivity exo-alpha-(2->6)-sialidase activity Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. EC:3.2.1.18 go.json exo-alpha-(2,6)-sialidase activity|exo-alpha-2,6-sialidase activity http://purl.obolibrary.org/obo/GO_0052795 GO:0003747 biolink:MolecularActivity translation release factor activity Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. go.json http://purl.obolibrary.org/obo/GO_0003747 GO:0052794 biolink:MolecularActivity exo-alpha-(2->3)-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. EC:3.2.1.18 go.json exo-alpha-(2,3)-sialidase activity|exo-alpha-2,3-sialidase activity http://purl.obolibrary.org/obo/GO_0052794 GO:0052793 biolink:MolecularActivity pectin acetylesterase activity Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin. go.json http://purl.obolibrary.org/obo/GO_0052793 GO:0052792 biolink:MolecularActivity endo-xylogalacturonan hydrolase activity Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position. go.json endo-galacturonase activity http://purl.obolibrary.org/obo/GO_0052792 GO:0003749 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0003749 GO:0052700 biolink:BiologicalProcess ergothioneine catabolic process The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. go.json (2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process|2-mercaptoergothioneine trimethylbetaine breakdown|2-mercaptoergothioneine trimethylbetaine catabolic process|2-mercaptoergothioneine trimethylbetaine catabolism|2-mercaptoergothioneine trimethylbetaine degradation|ergothioneine breakdown|ergothioneine catabolism|ergothioneine degradation http://purl.obolibrary.org/obo/GO_0052700 GO:0052704 biolink:BiologicalProcess ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate. Wikipedia:Ergothioneine go.json ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine http://purl.obolibrary.org/obo/GO_0052704 GO:0052703 biolink:BiologicalProcess cellular modified histidine biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. go.json cellular histidine derivative anabolism|cellular histidine derivative biosynthesis|cellular histidine derivative biosynthetic process|cellular histidine derivative formation|cellular histidine derivative synthesis|cellular modified histidine anabolism|cellular modified histidine biosynthesis|cellular modified histidine formation|cellular modified histidine synthesis|histidine derivative biosynthetic process http://purl.obolibrary.org/obo/GO_0052703 GO:0052702 biolink:BiologicalProcess cellular modified histidine catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. go.json cellular histidine derivative breakdown|cellular histidine derivative catabolic process|cellular histidine derivative catabolism|cellular histidine derivative degradation|cellular modified histidine breakdown|cellular modified histidine catabolism|cellular modified histidine degradation|histidine derivative catabolic process|modified histidine catabolic process|modified histidine catabolism http://purl.obolibrary.org/obo/GO_0052702 GO:0052701 biolink:BiologicalProcess cellular modified histidine metabolic process The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. go.json cellular histidine derivative metabolic process|cellular histidine derivative metabolism|cellular modified histidine metabolism|histidine derivative metabolic process|modified histidine metabolic process|modified histidine metabolism http://purl.obolibrary.org/obo/GO_0052701 GO:0052708 biolink:BiologicalProcess N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process The chemical reactions and pathways involving N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine. go.json N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolism|hercynine metabolic process|hercynine metabolism|histidine betaine metabolic process|histidine betaine metabolism http://purl.obolibrary.org/obo/GO_0052708 GO:0052707 biolink:BiologicalProcess N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). KEGG_REACTION:R01169 go.json hercynine biosynthesis from histidine|histidine betaine biosynthesis from histidine|histidine catabolic process to hercynine|histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine|histidine catabolism to hercynine http://purl.obolibrary.org/obo/GO_0052707 GO:0052706 biolink:MolecularActivity histidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine. go.json S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity|S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity|histidine methyltransferase activity|histidine-alpha-N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0052706 GO:0052705 biolink:MolecularActivity methylhistidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine. go.json S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity|S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity|histidine-alpha-N-methyltransferase activity|methylhistidine methyltransferase activity http://purl.obolibrary.org/obo/GO_0052705 GO:0052709 biolink:BiologicalProcess N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process The chemical reactions and pathways resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine. go.json N-alpha,N-alpha,N-alpha-trimethyl-L-histidine anabolism|N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis|N-alpha,N-alpha,N-alpha-trimethyl-L-histidine formation|N-alpha,N-alpha,N-alpha-trimethyl-L-histidine synthesis|hercynine anabolism|hercynine biosynthesis|hercynine biosynthetic process|hercynine formation|hercynine synthesis|histidine betaine anabolism|histidine betaine biosynthesis|histidine betaine biosynthetic process|histidine betaine formation|histidine betaine synthesis http://purl.obolibrary.org/obo/GO_0052709 GO:0052711 biolink:BiologicalProcess obsolete ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine OBSOLETE. The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). KEGG_REACTION:R04878 go.json N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine|ergothioneine biosynthesis from hercynine|ergothioneine biosynthesis from histidine betaine|hercynine catabolism to ergothioneine|histidine betaine catabolism to ergothioneine True http://purl.obolibrary.org/obo/GO_0052711 GO:0052710 biolink:BiologicalProcess N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process The chemical reactions and pathways resulting in the breakdown of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine. go.json N-alpha,N-alpha,N-alpha-trimethyl-L-histidine breakdown|N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism|N-alpha,N-alpha,N-alpha-trimethyl-L-histidine degradation|hercynine breakdown|hercynine catabolic process|hercynine catabolism|hercynine degradation|histidine betaine breakdown|histidine betaine catabolic process|histidine betaine catabolism|histidine betaine degradation http://purl.obolibrary.org/obo/GO_0052710 GO:0052715 biolink:MolecularActivity mannosyl-diinositol phosphorylceramide phospholipase activity Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol. go.json http://purl.obolibrary.org/obo/GO_0052715 GO:0052714 biolink:MolecularActivity mannosyl-inositol phosphorylceramide phospholipase activity Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol. go.json http://purl.obolibrary.org/obo/GO_0052714 GO:0052713 biolink:MolecularActivity inositol phosphorylceramide phospholipase activity Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol. go.json http://purl.obolibrary.org/obo/GO_0052713 GO:0052712 biolink:MolecularActivity inositol phosphosphingolipid phospholipase activity Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol. go.json http://purl.obolibrary.org/obo/GO_0052712 GO:0052719 biolink:MolecularActivity apurinic/apyrimidinic endoribonuclease activity Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends. go.json AP endoribonuclease activity|abasic endoribonuclease activity|apurinic endoribonuclease activity|apyrimidinic endoribonuclease activity http://purl.obolibrary.org/obo/GO_0052719 GO:0052718 biolink:CellularComponent tRNA-specific adenosine-34 deaminase complex A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human. go.json tRNA-A34 deaminase complex http://purl.obolibrary.org/obo/GO_0052718 GO:0052717 biolink:MolecularActivity tRNA-specific adenosine-34 deaminase activity Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule. EC:3.5.4.33|RHEA:43168 go.json tRNA(Ala)-A34 deaminase activity http://purl.obolibrary.org/obo/GO_0052717 GO:0052716 biolink:MolecularActivity hydroquinone:oxygen oxidoreductase activity Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O. EC:1.10.3.2|KEGG_REACTION:R00083|MetaCyc:LACCASE-RXN|RHEA:11276 go.json benzenediol:oxygen oxidoreductase activity|laccase reaction|p-diphenol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0052716 GO:0032439 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032439 GO:0032438 biolink:BiologicalProcess melanosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. go.json melanosome organisation|melanosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0032438 GO:0032437 biolink:CellularComponent cuticular plate A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. go.json http://purl.obolibrary.org/obo/GO_0032437 GO:0032436 biolink:BiologicalProcess positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. go.json activation of proteasomal ubiquitin-dependent protein catabolic process|stimulation of proteasomal ubiquitin-dependent protein catabolic process|up regulation of proteasomal ubiquitin-dependent protein catabolic process|up-regulation of proteasomal ubiquitin-dependent protein catabolic process|upregulation of proteasomal ubiquitin-dependent protein catabolic process http://purl.obolibrary.org/obo/GO_0032436 GO:0032435 biolink:BiologicalProcess negative regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. go.json down regulation of proteasomal ubiquitin-dependent protein catabolic process|down-regulation of proteasomal ubiquitin-dependent protein catabolic process|downregulation of proteasomal ubiquitin-dependent protein catabolic process|inhibition of proteasomal ubiquitin-dependent protein catabolic process http://purl.obolibrary.org/obo/GO_0032435 GO:0007479 biolink:BiologicalProcess leg disc proximal/distal pattern formation The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg. go.json http://purl.obolibrary.org/obo/GO_0007479 GO:0007478 biolink:BiologicalProcess leg disc morphogenesis The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura. go.json leg disc metamorphosis http://purl.obolibrary.org/obo/GO_0007478 GO:0007477 biolink:BiologicalProcess notum development The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007477 GO:0007476 biolink:BiologicalProcess imaginal disc-derived wing morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying. go.json wing morphogenesis http://purl.obolibrary.org/obo/GO_0007476 GO:0007475 biolink:BiologicalProcess apposition of dorsal and ventral imaginal disc-derived wing surfaces The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing. go.json apposition of dorsal and ventral wing surfaces http://purl.obolibrary.org/obo/GO_0007475 GO:0007474 biolink:BiologicalProcess imaginal disc-derived wing vein specification The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified. go.json wing vein specification http://purl.obolibrary.org/obo/GO_0007474 GO:0007473 biolink:BiologicalProcess wing disc proximal/distal pattern formation The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing. go.json http://purl.obolibrary.org/obo/GO_0007473 GO:0007472 biolink:BiologicalProcess wing disc morphogenesis The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura. go.json wing disc metamorphosis http://purl.obolibrary.org/obo/GO_0007472 GO:0007471 biolink:BiologicalProcess obsolete prothoracic morphogenesis OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized. go.json prothoracic morphogenesis True http://purl.obolibrary.org/obo/GO_0007471 GO:0007481 biolink:BiologicalProcess haltere disc morphogenesis The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. go.json haltere disc metamorphosis http://purl.obolibrary.org/obo/GO_0007481 GO:0007480 biolink:BiologicalProcess imaginal disc-derived leg morphogenesis The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007480 GO:0032434 biolink:BiologicalProcess regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. go.json http://purl.obolibrary.org/obo/GO_0032434 GO:0032433 biolink:CellularComponent filopodium tip The end of a filopodium distal to the body of the cell. go.json http://purl.obolibrary.org/obo/GO_0032433 GO:0032432 biolink:CellularComponent actin filament bundle An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. go.json actin cable http://purl.obolibrary.org/obo/GO_0032432 GO:0032431 biolink:BiologicalProcess activation of phospholipase A2 activity Any process that initiates the activity of the inactive enzyme phospholipase A2. go.json phospholipase A2 activation http://purl.obolibrary.org/obo/GO_0032431 gocheck_do_not_annotate GO:0032430 biolink:BiologicalProcess positive regulation of phospholipase A2 activity Any process that activates or increases the activity of the enzyme phospholipase A2. go.json activation of phospholipase A2 activity|stimulation of phospholipase A2 activity|up regulation of phospholipase A2 activity|up-regulation of phospholipase A2 activity|upregulation of phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0032430 gocheck_do_not_annotate GO:0032429 biolink:BiologicalProcess regulation of phospholipase A2 activity Any process that modulates the activity of the enzyme phospholipase A2. go.json http://purl.obolibrary.org/obo/GO_0032429 gocheck_do_not_annotate GO:0032428 biolink:MolecularActivity beta-N-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides. EC:3.2.1.53|MetaCyc:3.2.1.53-RXN go.json http://purl.obolibrary.org/obo/GO_0032428 GO:0032427 biolink:MolecularActivity GBD domain binding Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. go.json CRIB motif binding|Cdc42/Rac interactive binding motif binding|P21-Rho-binding domain binding|PMD binding http://purl.obolibrary.org/obo/GO_0032427 GO:0032426 biolink:CellularComponent stereocilium tip A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation. go.json http://purl.obolibrary.org/obo/GO_0032426 GO:0032425 biolink:BiologicalProcess positive regulation of mismatch repair Any process that activates or increases the frequency, rate or extent of mismatch repair. go.json activation of mismatch repair|stimulation of mismatch repair|up regulation of mismatch repair|up-regulation of mismatch repair|upregulation of mismatch repair http://purl.obolibrary.org/obo/GO_0032425 GO:0032424 biolink:BiologicalProcess negative regulation of mismatch repair Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair. go.json down regulation of mismatch repair|down-regulation of mismatch repair|downregulation of mismatch repair|inhibition of mismatch repair http://purl.obolibrary.org/obo/GO_0032424 GO:0007489 biolink:BiologicalProcess maintenance of imaginal histoblast diploidy The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells. go.json http://purl.obolibrary.org/obo/GO_0007489 GO:0007488 biolink:BiologicalProcess histoblast morphogenesis The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen. go.json histoblast metamorphosis http://purl.obolibrary.org/obo/GO_0007488 GO:0007487 biolink:BiologicalProcess analia development The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007487 GO:0007486 biolink:BiologicalProcess imaginal disc-derived female genitalia development The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. go.json female genital development http://purl.obolibrary.org/obo/GO_0007486 GO:0007485 biolink:BiologicalProcess imaginal disc-derived male genitalia development The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. go.json male genital development http://purl.obolibrary.org/obo/GO_0007485 GO:0007484 biolink:BiologicalProcess imaginal disc-derived genitalia development The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. go.json genital development http://purl.obolibrary.org/obo/GO_0007484 GO:0007483 biolink:BiologicalProcess genital disc morphogenesis The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut. go.json genital disc metamorphosis http://purl.obolibrary.org/obo/GO_0007483 GO:0007482 biolink:BiologicalProcess haltere development The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings. go.json http://purl.obolibrary.org/obo/GO_0007482 GO:0007492 biolink:BiologicalProcess endoderm development The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. go.json http://purl.obolibrary.org/obo/GO_0007492 GO:0007491 biolink:BiologicalProcess sternite morphogenesis The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment. go.json http://purl.obolibrary.org/obo/GO_0007491 GO:0007490 biolink:BiologicalProcess tergite morphogenesis The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment. go.json http://purl.obolibrary.org/obo/GO_0007490 GO:0032423 biolink:BiologicalProcess regulation of mismatch repair Any process that modulates the frequency, rate or extent of mismatch repair. go.json http://purl.obolibrary.org/obo/GO_0032423 GO:0032422 biolink:MolecularActivity purine-rich negative regulatory element binding Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. go.json PNR element binding http://purl.obolibrary.org/obo/GO_0032422 GO:0032421 biolink:CellularComponent stereocilium bundle A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. go.json stereocilia bundle http://purl.obolibrary.org/obo/GO_0032421 goslim_pir GO:0032420 biolink:CellularComponent stereocilium An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles. go.json http://purl.obolibrary.org/obo/GO_0032420 GO:0032419 biolink:CellularComponent obsolete extrinsic component of lysosome membrane OBSOLETE. The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to lysosomal membrane|extrinsic to lysosome membrane True http://purl.obolibrary.org/obo/GO_0032419 GO:0032418 biolink:BiologicalProcess lysosome localization Any process in which a lysosome is transported to, and/or maintained in, a specific location. go.json lysosome localisation http://purl.obolibrary.org/obo/GO_0032418 GO:0032417 biolink:BiologicalProcess positive regulation of sodium:proton antiporter activity Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). go.json activation of sodium:hydrogen antiporter activity|positive regulation of sodium:hydrogen antiporter activity|stimulation of sodium:hydrogen antiporter activity|up regulation of sodium:hydrogen antiporter activity|up-regulation of sodium:hydrogen antiporter activity|upregulation of sodium:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0032417 gocheck_do_not_annotate GO:0032416 biolink:BiologicalProcess negative regulation of sodium:proton antiporter activity Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). go.json down regulation of sodium:hydrogen antiporter activity|down-regulation of sodium:hydrogen antiporter activity|downregulation of sodium:hydrogen antiporter activity|inhibition of sodium:hydrogen antiporter activity|negative regulation of sodium:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0032416 gocheck_do_not_annotate GO:0032415 biolink:BiologicalProcess regulation of sodium:proton antiporter activity Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). go.json regulation of sodium:hydrogen antiporter activity http://purl.obolibrary.org/obo/GO_0032415 gocheck_do_not_annotate GO:0007459 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007459 GO:0032414 biolink:BiologicalProcess positive regulation of ion transmembrane transporter activity Any process that activates or increases the activity of an ion transporter. go.json activation of ion transporter activity|positive regulation of ion transporter activity|stimulation of ion transporter activity|up regulation of ion transporter activity|up-regulation of ion transporter activity|upregulation of ion transporter activity http://purl.obolibrary.org/obo/GO_0032414 gocheck_do_not_annotate GO:0007458 biolink:BiologicalProcess progression of morphogenetic furrow involved in compound eye morphogenesis The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc. go.json progression of morphogenetic furrow during compound eye morphogenesis http://purl.obolibrary.org/obo/GO_0007458 GO:0032413 biolink:BiologicalProcess negative regulation of ion transmembrane transporter activity Any process that stops or reduces the activity of an ion transporter. go.json down regulation of ion transporter activity|down-regulation of ion transporter activity|downregulation of ion transporter activity|inhibition of ion transporter activity|negative regulation of ion transporter activity http://purl.obolibrary.org/obo/GO_0032413 gocheck_do_not_annotate GO:0007457 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007457 GO:0007456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007456 GO:0007455 biolink:BiologicalProcess eye-antennal disc morphogenesis The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps. go.json eye-antennal disc metamorphosis http://purl.obolibrary.org/obo/GO_0007455 GO:0007454 biolink:BiologicalProcess labial disc morphogenesis The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis. go.json labial disc metamorphosis http://purl.obolibrary.org/obo/GO_0007454 GO:0007453 biolink:BiologicalProcess clypeo-labral disc morphogenesis The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus. go.json clypeo-labral disc metamorphosis|morphogenesis of structures derived from the clypeo-labral disc http://purl.obolibrary.org/obo/GO_0007453 GO:0007452 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007452 GO:0007451 biolink:BiologicalProcess dorsal/ventral lineage restriction, imaginal disc Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment. go.json dorsal-ventral lineage restriction, imaginal disc|dorsoventral lineage restriction, imaginal disc http://purl.obolibrary.org/obo/GO_0007451 GO:0007450 biolink:BiologicalProcess dorsal/ventral pattern formation, imaginal disc The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. go.json dorsal-ventral pattern formation, imaginal disc|dorsoventral pattern formation, imaginal disc http://purl.obolibrary.org/obo/GO_0007450 GO:0032412 biolink:BiologicalProcess regulation of monoatomic ion transmembrane transporter activity Any process that modulates the activity of an ion transporter. go.json regulation of ion transmembrane transporter activity|regulation of ion transporter activity http://purl.obolibrary.org/obo/GO_0032412 gocheck_do_not_annotate GO:0032411 biolink:BiologicalProcess positive regulation of transporter activity Any process that activates or increases the activity of a transporter. go.json activation of transporter activity|stimulation of transporter activity|up regulation of transporter activity|up-regulation of transporter activity|upregulation of transporter activity http://purl.obolibrary.org/obo/GO_0032411 gocheck_do_not_annotate GO:0032410 biolink:BiologicalProcess negative regulation of transporter activity Any process that stops or reduces the activity of a transporter. go.json down regulation of transporter activity|down-regulation of transporter activity|downregulation of transporter activity|inhibition of transporter activity http://purl.obolibrary.org/obo/GO_0032410 gocheck_do_not_annotate GO:0032409 biolink:BiologicalProcess regulation of transporter activity Any process that modulates the activity of a transporter. go.json http://purl.obolibrary.org/obo/GO_0032409 gocheck_do_not_annotate GO:0032408 biolink:MolecularActivity MutSbeta complex binding Binding to a MutSbeta mismatch repair complex. go.json http://purl.obolibrary.org/obo/GO_0032408 GO:0032407 biolink:MolecularActivity MutSalpha complex binding Binding to a MutSalpha mismatch repair complex. go.json http://purl.obolibrary.org/obo/GO_0032407 GO:0032406 biolink:MolecularActivity MutLbeta complex binding Binding to a MutLbeta mismatch repair complex. go.json http://purl.obolibrary.org/obo/GO_0032406 GO:0032405 biolink:MolecularActivity MutLalpha complex binding Binding to a MutLalpha mismatch repair complex. go.json http://purl.obolibrary.org/obo/GO_0032405 GO:0032404 biolink:MolecularActivity mismatch repair complex binding Binding to a mismatch repair complex. go.json http://purl.obolibrary.org/obo/GO_0032404 GO:0032403 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032403 GO:0007469 biolink:BiologicalProcess antennal development The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli. go.json http://purl.obolibrary.org/obo/GO_0007469 GO:0007468 biolink:BiologicalProcess obsolete regulation of rhodopsin gene expression OBSOLETE. Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation. go.json regulation of rhodopsin gene activity True http://purl.obolibrary.org/obo/GO_0007468 GO:0032402 biolink:BiologicalProcess melanosome transport The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032402 GO:0007467 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007467 GO:0007466 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007466 GO:0007465 biolink:BiologicalProcess R7 cell fate commitment The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium. go.json http://purl.obolibrary.org/obo/GO_0007465 GO:0007464 biolink:BiologicalProcess R3/R4 cell fate commitment The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres. go.json http://purl.obolibrary.org/obo/GO_0007464 GO:0007463 biolink:BiologicalProcess R2/R5 cell fate commitment The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres. go.json http://purl.obolibrary.org/obo/GO_0007463 GO:0007462 biolink:BiologicalProcess R1/R6 cell fate commitment The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres. go.json http://purl.obolibrary.org/obo/GO_0007462 GO:0007461 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007461 GO:0007460 biolink:BiologicalProcess R8 cell fate commitment The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium. go.json restriction of R8 fate http://purl.obolibrary.org/obo/GO_0007460 GO:0007470 biolink:BiologicalProcess prothoracic disc morphogenesis The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle. go.json prothoracic disc metamorphosis http://purl.obolibrary.org/obo/GO_0007470 GO:0032401 biolink:BiologicalProcess establishment of melanosome localization The directed movement of a melanosome to a specific location. go.json establishment of melanosome localisation http://purl.obolibrary.org/obo/GO_0032401 GO:0032400 biolink:BiologicalProcess melanosome localization Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. go.json melanosome localisation http://purl.obolibrary.org/obo/GO_0032400 GO:0007439 biolink:BiologicalProcess ectodermal digestive tract development The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. go.json ectodermal gut development http://purl.obolibrary.org/obo/GO_0007439 GO:0007438 biolink:BiologicalProcess oenocyte development The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. go.json http://purl.obolibrary.org/obo/GO_0007438 GO:0007437 biolink:BiologicalProcess adult salivary gland morphogenesis The process in which the anatomical structures of the adult salivary gland are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0007437 GO:0007436 biolink:BiologicalProcess larval salivary gland morphogenesis The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0007436 GO:0007435 biolink:BiologicalProcess salivary gland morphogenesis The process in which the anatomical structures of the salivary gland are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0007435 GO:0007434 biolink:BiologicalProcess adult salivary gland boundary specification Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. go.json larval salivary gland determination http://purl.obolibrary.org/obo/GO_0007434 GO:0007433 biolink:BiologicalProcess larval salivary gland boundary specification Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. go.json larval salivary gland determination http://purl.obolibrary.org/obo/GO_0007433 GO:0007432 biolink:BiologicalProcess salivary gland boundary specification Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. go.json salivary gland determination http://purl.obolibrary.org/obo/GO_0007432 GO:0007431 biolink:BiologicalProcess salivary gland development The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. go.json http://purl.obolibrary.org/obo/GO_0007431 goslim_drosophila GO:0007430 biolink:BiologicalProcess terminal branching, open tracheal system Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster. go.json terminal branching of trachea, cytoplasmic projection extension http://purl.obolibrary.org/obo/GO_0007430 GO:0007449 biolink:BiologicalProcess proximal/distal pattern formation, imaginal disc The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. go.json http://purl.obolibrary.org/obo/GO_0007449 GO:0007448 biolink:BiologicalProcess anterior/posterior pattern specification, imaginal disc The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form. go.json http://purl.obolibrary.org/obo/GO_0007448 GO:0007447 biolink:BiologicalProcess imaginal disc pattern formation The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. go.json http://purl.obolibrary.org/obo/GO_0007447 GO:0007446 biolink:BiologicalProcess imaginal disc growth The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. go.json http://purl.obolibrary.org/obo/GO_0007446 GO:0007445 biolink:BiologicalProcess determination of imaginal disc primordium Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment. go.json http://purl.obolibrary.org/obo/GO_0007445 GO:0007444 biolink:BiologicalProcess imaginal disc development The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.). go.json http://purl.obolibrary.org/obo/GO_0007444 GO:0007443 biolink:BiologicalProcess Malpighian tubule morphogenesis The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. go.json http://purl.obolibrary.org/obo/GO_0007443 GO:0007442 biolink:BiologicalProcess hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0007442 GO:0007441 biolink:BiologicalProcess anterior midgut (ectodermal) morphogenesis The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0007441 GO:0007440 biolink:BiologicalProcess foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0007440 GO:0007419 biolink:BiologicalProcess ventral cord development The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms. go.json http://purl.obolibrary.org/obo/GO_0007419 GO:0007418 biolink:BiologicalProcess ventral midline development The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate. go.json http://purl.obolibrary.org/obo/GO_0007418 GO:0007417 biolink:BiologicalProcess central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. Wikipedia:Neural_development go.json CNS development http://purl.obolibrary.org/obo/GO_0007417 GO:0007416 biolink:BiologicalProcess synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). Wikipedia:Synaptogenesis go.json synapse biogenesis|synaptogenesis http://purl.obolibrary.org/obo/GO_0007416 goslim_synapse GO:0007415 biolink:BiologicalProcess defasciculation of motor neuron axon Separation of a motor axon away from a bundle of axons known as a fascicle. go.json http://purl.obolibrary.org/obo/GO_0007415 GO:0007414 biolink:BiologicalProcess axonal defasciculation Separation of axons away from a bundle of axons known as a fascicle. go.json defasciculation of neuron http://purl.obolibrary.org/obo/GO_0007414 GO:0007413 biolink:BiologicalProcess axonal fasciculation The collection of axons into a bundle of rods, known as a fascicle. go.json fasciculation of neuron http://purl.obolibrary.org/obo/GO_0007413 GO:0007412 biolink:BiologicalProcess axon target recognition The process in which an axon recognizes and binds to a set of cells with which it may form stable connections. go.json http://purl.obolibrary.org/obo/GO_0007412 GO:0007411 biolink:BiologicalProcess axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. Wikipedia:Axon_guidance go.json axon chemotaxis|axon growth cone guidance|axon pathfinding http://purl.obolibrary.org/obo/GO_0007411 GO:0007410 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007410 GO:0007429 biolink:BiologicalProcess secondary branching, open tracheal system Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster. go.json secondary tracheal branching http://purl.obolibrary.org/obo/GO_0007429 GO:0007428 biolink:BiologicalProcess primary branching, open tracheal system Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster. go.json primary tracheal branching http://purl.obolibrary.org/obo/GO_0007428 GO:0007427 biolink:BiologicalProcess epithelial cell migration, open tracheal system The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster. go.json tracheal cell migration|tracheal epithelial cell migration http://purl.obolibrary.org/obo/GO_0007427 GO:0007426 biolink:BiologicalProcess tracheal outgrowth, open tracheal system The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007426 GO:0007425 biolink:BiologicalProcess epithelial cell fate determination, open tracheal system The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster. go.json tracheal cell fate determination|tracheal epithelial cell fate determination|tracheal placode cell fate determination http://purl.obolibrary.org/obo/GO_0007425 GO:0007424 biolink:BiologicalProcess open tracheal system development The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007424 GO:0007423 biolink:BiologicalProcess sensory organ development The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. go.json sense organ development http://purl.obolibrary.org/obo/GO_0007423 goslim_drosophila GO:0007422 biolink:BiologicalProcess peripheral nervous system development The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. go.json http://purl.obolibrary.org/obo/GO_0007422 GO:0007421 biolink:BiologicalProcess stomatogastric nervous system development The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007421 GO:0007420 biolink:BiologicalProcess brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). go.json http://purl.obolibrary.org/obo/GO_0007420 GO:0032492 biolink:BiologicalProcess detection of molecule of oomycetes origin The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal. go.json detection of oomycetes associated molecule http://purl.obolibrary.org/obo/GO_0032492 GO:0032491 biolink:BiologicalProcess detection of molecule of fungal origin The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal. go.json detection of fungal associated molecule|detection of fungus associated molecule http://purl.obolibrary.org/obo/GO_0032491 GO:0032490 biolink:BiologicalProcess detection of molecule of bacterial origin The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. go.json detection of bacteria associated molecule|detection of bacterial associated molecule|detection of bacterium associated molecule http://purl.obolibrary.org/obo/GO_0032490 GO:0032499 biolink:BiologicalProcess detection of peptidoglycan The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule. go.json http://purl.obolibrary.org/obo/GO_0032499 GO:0032498 biolink:BiologicalProcess detection of muramyl dipeptide The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0032498 GO:0032497 biolink:BiologicalProcess detection of lipopolysaccharide The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. go.json detection of LPS http://purl.obolibrary.org/obo/GO_0032497 GO:0032496 biolink:BiologicalProcess response to lipopolysaccharide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. go.json response to LPS|response to endotoxin http://purl.obolibrary.org/obo/GO_0032496 GO:0032495 biolink:BiologicalProcess response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0032495 GO:0032494 biolink:BiologicalProcess response to peptidoglycan Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. go.json http://purl.obolibrary.org/obo/GO_0032494 GO:0032493 biolink:BiologicalProcess response to bacterial lipoprotein Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. go.json http://purl.obolibrary.org/obo/GO_0032493 GO:0032481 biolink:BiologicalProcess positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json activation of type I interferon production|positive regulation of type I IFN production|stimulation of type I interferon production|up regulation of type I interferon production|up-regulation of type I interferon production|upregulation of type I interferon production http://purl.obolibrary.org/obo/GO_0032481 GO:0032480 biolink:BiologicalProcess negative regulation of type I interferon production Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json down regulation of type I interferon production|down-regulation of type I interferon production|downregulation of type I interferon production|inhibition of type I interferon production|negative regulation of type I IFN production http://purl.obolibrary.org/obo/GO_0032480 GO:0032489 biolink:BiologicalProcess regulation of Cdc42 protein signal transduction Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0032489 GO:0032488 biolink:BiologicalProcess Cdc42 protein signal transduction The series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state. go.json Cdc42 signaling|Cdc42 signaling pathway|cdc42 signalling pathway http://purl.obolibrary.org/obo/GO_0032488 GO:0032487 biolink:BiologicalProcess regulation of Rap protein signal transduction Any process that modulates the frequency, rate or extent of Rap protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0032487 GO:0032486 biolink:BiologicalProcess Rap protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state. go.json http://purl.obolibrary.org/obo/GO_0032486 GO:0032485 biolink:BiologicalProcess regulation of Ral protein signal transduction Any process that modulates the frequency, rate or extent of Ral protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0032485 GO:0032484 biolink:BiologicalProcess Ral protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state. go.json http://purl.obolibrary.org/obo/GO_0032484 GO:0032483 biolink:BiologicalProcess regulation of Rab protein signal transduction Any process that modulates the frequency, rate or extent of Rab protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0032483 GO:0032482 biolink:BiologicalProcess Rab protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. go.json http://purl.obolibrary.org/obo/GO_0032482 GO:0032479 biolink:BiologicalProcess regulation of type I interferon production Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json regulation of type I IFN production http://purl.obolibrary.org/obo/GO_0032479 GO:0032470 biolink:BiologicalProcess positive regulation of endoplasmic reticulum calcium ion concentration Any process that increases the concentration of calcium ions in the endoplasmic reticulum. go.json elevation of ER calcium ion concentration|elevation of calcium ion concentration in endoplasmic reticulum|elevation of endoplasmic reticulum calcium ion concentration|endoplasmic reticulum calcium ion concentration elevation http://purl.obolibrary.org/obo/GO_0032470 GO:0032478 biolink:CellularComponent heterotetrameric decaprenyl diphosphate synthase complex A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1. go.json http://purl.obolibrary.org/obo/GO_0032478 GO:0032477 biolink:CellularComponent homodimeric decaprenyl diphosphate synthase complex A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0032477 GO:0032476 biolink:CellularComponent decaprenyl diphosphate synthase complex A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. go.json http://purl.obolibrary.org/obo/GO_0032476 goslim_pir GO:0032475 biolink:BiologicalProcess otolith formation The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts. go.json http://purl.obolibrary.org/obo/GO_0032475 GO:0032474 biolink:BiologicalProcess otolith morphogenesis The process in which the anatomical structures of an otolith are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0032474 GO:0032473 biolink:CellularComponent cytoplasmic side of mitochondrial outer membrane The external (cytoplasmic) face of the mitochondrial outer membrane. go.json cytosolic side of mitochondrial outer membrane|external leaflet of mitochondrial outer membrane|external side of mitochondrial envelope|external side of mitochondrial outer membrane http://purl.obolibrary.org/obo/GO_0032473 GO:0032472 biolink:BiologicalProcess Golgi calcium ion transport The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus. go.json Golgi calcium transport http://purl.obolibrary.org/obo/GO_0032472 GO:0032471 biolink:BiologicalProcess negative regulation of endoplasmic reticulum calcium ion concentration Any process that decreases the concentration of calcium ions in the endoplasmic reticulum. go.json ER calcium ion concentration reduction|endoplasmic reticulum calcium ion concentration reduction|reduction of ER calcium ion concentration|reduction of calcium ion concentration in ER|reduction of calcium ion concentration in endoplasmic reticulum|reduction of endoplasmic reticulum calcium ion concentration http://purl.obolibrary.org/obo/GO_0032471 GO:0032469 biolink:BiologicalProcess endoplasmic reticulum calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. go.json ER calcium ion concentration regulation|ER calcium ion homeostasis|calcium ion homeostasis in ER|calcium ion homeostasis in endoplasmic reticulum|endoplasmic reticulum calcium ion concentration regulation|regulation of ER calcium ion concentration|regulation of calcium ion concentration in ER|regulation of calcium ion concentration in endoplasmic reticulum|regulation of endoplasmic reticulum calcium ion concentration http://purl.obolibrary.org/obo/GO_0032469 GO:0032468 biolink:BiologicalProcess Golgi calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings. go.json Golgi calcium ion concentration regulation|calcium ion homeostasis in Golgi|regulation of Golgi calcium ion concentration|regulation of calcium ion concentration in Golgi http://purl.obolibrary.org/obo/GO_0032468 GO:0032467 biolink:BiologicalProcess positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. go.json activation of cytokinesis|positive regulation of cell cycle cytokinesis|stimulation of cytokinesis|up regulation of cytokinesis|up-regulation of cytokinesis|upregulation of cytokinesis http://purl.obolibrary.org/obo/GO_0032467 GO:0032466 biolink:BiologicalProcess negative regulation of cytokinesis Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. go.json down regulation of cytokinesis|down-regulation of cytokinesis|downregulation of cytokinesis|inhibition of cytokinesis|negative regulation of cell cycle cytokinesis http://purl.obolibrary.org/obo/GO_0032466 GO:0032465 biolink:BiologicalProcess regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. go.json regulation of cell cycle cytokinesis http://purl.obolibrary.org/obo/GO_0032465 GO:0032464 biolink:BiologicalProcess positive regulation of protein homooligomerization Any process that activates or increases the frequency, rate or extent of protein homooligomerization. go.json activation of protein homooligomerization|induction of protein homooligomerization|stimulation of protein homooligomerization|up regulation of protein homooligomerization|up-regulation of protein homooligomerization|upregulation of protein homooligomerization http://purl.obolibrary.org/obo/GO_0032464 GO:0032463 biolink:BiologicalProcess negative regulation of protein homooligomerization Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization. go.json down regulation of protein homooligomerization|down-regulation of protein homooligomerization|downregulation of protein homooligomerization|inhibition of protein homooligomerization http://purl.obolibrary.org/obo/GO_0032463 GO:0032462 biolink:BiologicalProcess regulation of protein homooligomerization Any process that modulates the frequency, rate or extent of protein homooligomerization. go.json http://purl.obolibrary.org/obo/GO_0032462 GO:0032461 biolink:BiologicalProcess positive regulation of protein oligomerization Any process that activates or increases the frequency, rate or extent of protein oligomerization. go.json activation of protein oligomerization|induction of protein oligomerization|stimulation of protein oligomerization|up regulation of protein oligomerization|up-regulation of protein oligomerization|upregulation of protein oligomerization http://purl.obolibrary.org/obo/GO_0032461 GO:0032460 biolink:BiologicalProcess negative regulation of protein oligomerization Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. go.json down regulation of protein oligomerization|down-regulation of protein oligomerization|downregulation of protein oligomerization|inhibition of protein oligomerization http://purl.obolibrary.org/obo/GO_0032460 GO:0032459 biolink:BiologicalProcess regulation of protein oligomerization Any process that modulates the frequency, rate or extent of protein oligomerization. go.json http://purl.obolibrary.org/obo/GO_0032459 GO:0032458 biolink:BiologicalProcess slow endocytic recycling The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. go.json http://purl.obolibrary.org/obo/GO_0032458 GO:0032457 biolink:BiologicalProcess fast endocytic recycling The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. go.json direct endocytic recycling http://purl.obolibrary.org/obo/GO_0032457 GO:0007499 biolink:BiologicalProcess ectoderm and mesoderm interaction A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm. go.json ectoderm/mesoderm interaction http://purl.obolibrary.org/obo/GO_0007499 GO:0007498 biolink:BiologicalProcess mesoderm development The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. go.json http://purl.obolibrary.org/obo/GO_0007498 goslim_drosophila GO:0007497 biolink:BiologicalProcess posterior midgut development The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007497 GO:0007496 biolink:BiologicalProcess anterior midgut development The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007496 GO:0007495 biolink:BiologicalProcess visceral mesoderm-endoderm interaction involved in midgut development The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut. go.json visceral mesoderm/endoderm interaction http://purl.obolibrary.org/obo/GO_0007495 GO:0007494 biolink:BiologicalProcess midgut development The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. go.json http://purl.obolibrary.org/obo/GO_0007494 GO:0007493 biolink:BiologicalProcess endodermal cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json endoderm cell fate determination http://purl.obolibrary.org/obo/GO_0007493 GO:0032456 biolink:BiologicalProcess endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. go.json retrograde transport of endocytic vesicles|retrograde transport, endosome to plasma membrane http://purl.obolibrary.org/obo/GO_0032456 GO:0032455 biolink:BiologicalProcess nerve growth factor processing The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor. go.json NGF processing|beta-nerve growth factor processing http://purl.obolibrary.org/obo/GO_0032455 GO:0032454 biolink:MolecularActivity histone H3K9 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. Reactome:R-HSA-9011949|Reactome:R-HSA-9011985|Reactome:R-HSA-997263 go.json histone H3-K49 demethylase activity|histone H3-methyl-lysine-9 demethylase activity|histone demethylase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0032454 GO:0032453 biolink:MolecularActivity histone H3K4 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. Reactome:R-HSA-9822461|Reactome:R-HSA-9822467 go.json histone H3-K4 demethylase activity|histone H3-methyl-lysine-4 demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3K4-specific) http://purl.obolibrary.org/obo/GO_0032453 GO:0032452 biolink:MolecularActivity histone demethylase activity Catalysis of the removal of a methyl group from a histone. Reactome:R-HSA-3214912|Reactome:R-HSA-4722133|Reactome:R-HSA-4724279|Reactome:R-HSA-4724284|Reactome:R-HSA-4754176|Reactome:R-HSA-4754181|Reactome:R-HSA-4754187|Reactome:R-HSA-5423117|Reactome:R-HSA-5625797|Reactome:R-HSA-5625848|Reactome:R-HSA-5625870|Reactome:R-HSA-5661114|Reactome:R-HSA-5661115|Reactome:R-HSA-5661116|Reactome:R-HSA-5661120|Reactome:R-HSA-5661121|Reactome:R-HSA-5661122|Reactome:R-HSA-5661123|Reactome:R-HSA-5661124|Reactome:R-HSA-5661125 go.json http://purl.obolibrary.org/obo/GO_0032452 GO:0032451 biolink:MolecularActivity demethylase activity Catalysis of the removal of a methyl group from a substrate. go.json http://purl.obolibrary.org/obo/GO_0032451 goslim_pir GO:0032450 biolink:MolecularActivity maltose alpha-glucosidase activity Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. EC:3.2.1.20|MetaCyc:RXN-15910 go.json maltase activity http://purl.obolibrary.org/obo/GO_0032450 GO:0032449 biolink:CellularComponent CBM complex A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation. go.json CARMA1-BCL10-Malt1 complex http://purl.obolibrary.org/obo/GO_0032449 GO:0032448 biolink:MolecularActivity DNA hairpin binding Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences. go.json http://purl.obolibrary.org/obo/GO_0032448 GO:0032447 biolink:BiologicalProcess protein urmylation Covalent attachment of the ubiquitin-like protein URM1 to another protein. go.json http://purl.obolibrary.org/obo/GO_0032447 GO:0032446 biolink:BiologicalProcess protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. go.json http://purl.obolibrary.org/obo/GO_0032446 GO:0032445 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032445 GO:0032444 biolink:CellularComponent activin responsive factor complex A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor. go.json ARF complex http://purl.obolibrary.org/obo/GO_0032444 GO:0032443 biolink:BiologicalProcess regulation of ergosterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. go.json http://purl.obolibrary.org/obo/GO_0032443 GO:0032442 biolink:MolecularActivity phenylcoumaran benzylic ether reductase activity Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+. go.json PCBER activity http://purl.obolibrary.org/obo/GO_0032442 GO:0032441 biolink:MolecularActivity pheophorbide a oxygenase activity Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O. EC:1.14.15.17|MetaCyc:RXN-7740|RHEA:48140 go.json http://purl.obolibrary.org/obo/GO_0032441 GO:0032440 biolink:MolecularActivity 2-alkenal reductase [NAD(P)+] activity Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+. EC:1.3.1.74 go.json NAD(P)H-dependent alkenal/one oxidoreductase activity|n-alkanal:NAD(P)+ 2-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0032440 GO:0140346 biolink:MolecularActivity phosphatidylserine flippase activity Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json phosphatidylserine flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140346 GO:0140345 biolink:MolecularActivity phosphatidylcholine flippase activity Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json phosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140345 GO:0140348 biolink:MolecularActivity lysophosphatidylcholine flippase activity Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140348 GO:0140347 biolink:MolecularActivity N-retinylidene-phosphatidylethanolamine flippase activity Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140347 GO:0140340 biolink:MolecularActivity cerebroside transfer activity Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location. go.json cerebroside carrier activity http://purl.obolibrary.org/obo/GO_0140340 GO:0140341 biolink:MolecularActivity phosphatidylethanolamine floppase activity Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaftlet) http://purl.obolibrary.org/obo/GO_0140341 GO:0140344 biolink:MolecularActivity triglyceride transfer activity Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location. go.json triglyceride carrier activity http://purl.obolibrary.org/obo/GO_0140344 GO:0140343 biolink:MolecularActivity phosphatidylserine transfer activity Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. go.json intermembrane phosphatidylserine carrier activity http://purl.obolibrary.org/obo/GO_0140343 GO:0140334 biolink:BiologicalProcess lipopolysaccharide localization to cell outer membrane A process in which a lipopolysaccharide is transported to the cell outer membrane. go.json LPS localization to cell outer membrane http://purl.obolibrary.org/obo/GO_0140334 GO:0140337 biolink:MolecularActivity diacylglyceride transfer activity Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location. go.json diacylglyceride carrier activity http://purl.obolibrary.org/obo/GO_0140337 GO:0140339 biolink:MolecularActivity phosphatidylglycerol transfer activity Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location. go.json phosphatidylglycerol carrier activity http://purl.obolibrary.org/obo/GO_0140339 GO:0140338 biolink:MolecularActivity sphingomyelin transfer activity Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. go.json sphingomyelin carrier activity|sphingosine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0140338 GO:0140331 biolink:BiologicalProcess aminophospholipid translocation The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. go.json http://purl.obolibrary.org/obo/GO_0140331 GO:0140330 biolink:BiologicalProcess xenobiotic detoxification by transmembrane export across the cell outer membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane. go.json http://purl.obolibrary.org/obo/GO_0140330 GO:0140333 biolink:MolecularActivity glycerophospholipid flippase activity Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json glycerophospholipid flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140333 GO:0140332 biolink:MolecularActivity lipopolysaccharide transfer activity Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. go.json intermembrane LPS transporter activity|intermembrane lipopolysaccharide transfer activity|intermembrane lipopolysaccharide transporter activity|lipopolysaccharide carrier activity http://purl.obolibrary.org/obo/GO_0140332 GO:0140368 biolink:CellularComponent decoy receptor complex A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound. go.json osteoclastogenesis inhibitory factor|osteoprotegerin complex http://purl.obolibrary.org/obo/GO_0140368 GO:0140367 biolink:BiologicalProcess antibacterial innate immune response An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. go.json http://purl.obolibrary.org/obo/GO_0140367 GO:0140360 biolink:MolecularActivity cyclic-GMP-AMP transmembrane transporter activity Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0140360 GO:0140362 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140362 GO:0140361 biolink:BiologicalProcess cyclic-GMP-AMP transmembrane import across plasma membrane The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140361 GO:0140364 biolink:CellularComponent GW body A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs. go.json GW-body http://purl.obolibrary.org/obo/GO_0140364 GO:0140363 biolink:CellularComponent TIS granule A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER). go.json http://purl.obolibrary.org/obo/GO_0140363 GO:0140366 biolink:CellularComponent galectin lattice A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids. go.json http://purl.obolibrary.org/obo/GO_0140366 GO:0140365 biolink:CellularComponent RNP body A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules. go.json BR-body http://purl.obolibrary.org/obo/GO_0140365 GO:0140357 biolink:BiologicalProcess heme export from vacuole to cytoplasm The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140357 GO:0140359 biolink:MolecularActivity ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. Reactome:R-HSA-266070|Reactome:R-HSA-429157|Reactome:R-HSA-5362459|Reactome:R-HSA-5387389|Reactome:R-HSA-9661405|Reactome:R-HSA-9750656|TC:3.A.1|Wikipedia:ATP-binding_cassette_transporter go.json ABC transporter|ABC-type efflux permease activity|ABC-type efflux porter activity|ABC-type transmembrane transporter activity|ABC-type uptake permease activity|ATP binding cassette transporter|ATP-binding cassette (ABC) transporter activity|ATP-binding cassette transporter http://purl.obolibrary.org/obo/GO_0140359 GO:0140358 biolink:MolecularActivity P-type transmembrane transporter activity Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. TC:3.A.3|Wikipedia:P-type_ATPase go.json E1-E2 ATPase|P-type ATPase http://purl.obolibrary.org/obo/GO_0140358 GO:0140351 biolink:MolecularActivity glycosylceramide flippase activity Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar. go.json galactocerebroside flippase activity|galactosylceramide flippase activity|glucosylceramide flippase activity|glycoceramide flippase activity|glycosylceramide flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140351 GO:0140353 biolink:BiologicalProcess lipid export from cell The directed movement of a lipid from a cell, into the extracellular region. go.json lipid efflux http://purl.obolibrary.org/obo/GO_0140353 GO:0140352 biolink:BiologicalProcess export from cell The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. go.json efflux http://purl.obolibrary.org/obo/GO_0140352 GO:0140355 biolink:MolecularActivity cargo receptor ligand activity The activity of a gene product that interacts with a cargo receptor and initiates endocytosis. Reactome:R-HSA-3000074|Reactome:R-HSA-3000120|Reactome:R-HSA-3132759 go.json cargo http://purl.obolibrary.org/obo/GO_0140355 GO:0140354 biolink:BiologicalProcess lipid import into cell The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. go.json lipid uptake http://purl.obolibrary.org/obo/GO_0140354 GO:0140302 biolink:BiologicalProcess pollen-style interaction The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte. go.json http://purl.obolibrary.org/obo/GO_0140302 GO:0140301 biolink:BiologicalProcess pollen-stigma interaction The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae. go.json http://purl.obolibrary.org/obo/GO_0140301 GO:0140303 biolink:MolecularActivity intramembrane lipid transporter activity Enables the transport of a lipid from a region of a membrane to a different region on the same membrane. go.json flippase activity|translocase activity http://purl.obolibrary.org/obo/GO_0140303 GO:0140306 biolink:MolecularActivity lipoprotein releasing activity The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex. go.json http://purl.obolibrary.org/obo/GO_0140306 GO:0140300 biolink:BiologicalProcess serine import into mitochondrion The process in which serine is transported from the cytosol into the mitochondrial matrix. go.json http://purl.obolibrary.org/obo/GO_0140300 GO:0140323 biolink:MolecularActivity obsolete solute:monoatomic anion antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in). go.json solute:anion antiporter activity True http://purl.obolibrary.org/obo/GO_0140323 GO:0140326 biolink:MolecularActivity ATPase-coupled intramembrane lipid transporter activity Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. EC:7.6.2.1|MetaCyc:3.6.3.1-RXN|Reactome:R-HSA-939763|Reactome:R-HSA-947591 go.json ATPase-coupled phospholipid transporter activity|ATPase-dependent phospholipid transporter activity|aminophospholipid-transporting ATPase|phospholipid flippase activity|phospholipid translocating ATPase activity|phospholipid-translocating ATPase activity|phospholipid-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0140326 GO:0140325 biolink:BiologicalProcess negative regulation of protein localization to medial cortex Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex. go.json http://purl.obolibrary.org/obo/GO_0140325 GO:0140328 biolink:MolecularActivity floppase activity Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json floppase activity (cytosolic to exoplasmic leaftlet) http://purl.obolibrary.org/obo/GO_0140328 GO:0140327 biolink:MolecularActivity flippase activity Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json flippase activity (exoplasmic to cytosolic leaftlet) http://purl.obolibrary.org/obo/GO_0140327 GO:0140329 biolink:BiologicalProcess lysophospholipid translocation The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. go.json http://purl.obolibrary.org/obo/GO_0140329 GO:0140320 biolink:MolecularActivity PAMP receptor decoy activity Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response. go.json pathogen-associated molecular pattern receptor decoy activity|pattern recognition receptor decoy activity http://purl.obolibrary.org/obo/GO_0140320 GO:0140321 biolink:BiologicalProcess symbiont-mediated suppression of host autophagy Any process in which a symbiont organism decreases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by symbiont of host autophagy|suppression of host autophagy http://purl.obolibrary.org/obo/GO_0140321 GO:0140313 biolink:MolecularActivity molecular sequestering activity Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. Reactome:R-HSA-3245898 go.json http://purl.obolibrary.org/obo/GO_0140313 goslim_drosophila|goslim_generic|prokaryote_subset GO:0140312 biolink:MolecularActivity cargo adaptor activity Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. go.json endocytic adaptor activity http://purl.obolibrary.org/obo/GO_0140312 GO:0140315 biolink:MolecularActivity iron ion sequestering activity Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json http://purl.obolibrary.org/obo/GO_0140315 GO:0140314 biolink:MolecularActivity calcium ion sequestering activity Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json http://purl.obolibrary.org/obo/GO_0140314 GO:0140317 biolink:BiologicalProcess export across cell outer membrane The directed movement of a substance across the outer membrane in cells with two membranes. go.json http://purl.obolibrary.org/obo/GO_0140317 GO:0140316 biolink:MolecularActivity obsolete vesicular transport adaptor activity OBSOLETE. Binding directly to sorting signals in the cytosolic tails of transmembrane cargos (or transmembrane cargo receptors serving as recognition interfaces for lumenal cargos), to concentrate them into vesicles or tubules for transport via intracellular vesicular transport or the secretory pathway. go.json True http://purl.obolibrary.org/obo/GO_0140316 GO:0140319 biolink:MolecularActivity receptor decoy activity Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor. go.json decoy death receptor activity|decoy receptor http://purl.obolibrary.org/obo/GO_0140319 GO:0140318 biolink:MolecularActivity protein transporter activity Directly binding to a specific protein and delivering it to a specific cellular location. Reactome:R-HSA-2248891|Reactome:R-HSA-9662747|Reactome:R-HSA-9662818 go.json protein carrier activity|protein transport chaperone http://purl.obolibrary.org/obo/GO_0140318 GO:0140311 biolink:MolecularActivity protein sequestering activity Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json http://purl.obolibrary.org/obo/GO_0140311 GO:0007409 biolink:BiologicalProcess axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. go.json axon growth|axon morphogenesis|neuron long process generation http://purl.obolibrary.org/obo/GO_0007409 GO:0071990 biolink:BiologicalProcess maintenance of protein location to spindle pole body Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere. go.json maintenance of protein location at spindle pole body|maintenance of protein location in spindle pole body http://purl.obolibrary.org/obo/GO_0071990 GO:0007408 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007408 GO:0007407 biolink:BiologicalProcess neuroblast activation A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. go.json http://purl.obolibrary.org/obo/GO_0007407 GO:0007406 biolink:BiologicalProcess negative regulation of neuroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. go.json down regulation of neuroblast proliferation|down-regulation of neuroblast proliferation|downregulation of neuroblast proliferation|inhibition of neuroblast proliferation|suppression of neuroblast proliferation http://purl.obolibrary.org/obo/GO_0007406 GO:0007405 biolink:BiologicalProcess neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. go.json http://purl.obolibrary.org/obo/GO_0007405 GO:0007404 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007404 GO:0007403 biolink:BiologicalProcess glial cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0007403 GO:0007402 biolink:BiologicalProcess ganglion mother cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0007402 GO:0007401 biolink:BiologicalProcess obsolete pan-neural process OBSOLETE. (Was not defined before being made obsolete). go.json pan-neural process True http://purl.obolibrary.org/obo/GO_0007401 GO:0007400 biolink:BiologicalProcess neuroblast fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus. go.json neuroblast cell fate determination|neuroblast identity determination http://purl.obolibrary.org/obo/GO_0007400 GO:0071999 biolink:BiologicalProcess extracellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures. go.json extracellular polysaccharide breakdown|extracellular polysaccharide catabolism|extracellular polysaccharide degradation http://purl.obolibrary.org/obo/GO_0071999 GO:0071998 biolink:BiologicalProcess ascospore release from ascus A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive. go.json ascospore liberation http://purl.obolibrary.org/obo/GO_0071998 GO:0071997 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071997 GO:0071996 biolink:BiologicalProcess glutathione transmembrane import into vacuole The directed movement of glutathione into the vacuole across the vacuolar membrane. go.json glutathione transport into vacuole http://purl.obolibrary.org/obo/GO_0071996 GO:0071995 biolink:BiologicalProcess phytochelatin import into vacuole The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. go.json cadystin import into vacuole|phytochelatin transport into vacuole http://purl.obolibrary.org/obo/GO_0071995 GO:0071994 biolink:BiologicalProcess phytochelatin transmembrane transport The process in which a phytochelatin is transported across a membrane. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. go.json cadystin transmembrane transport|phytochelatin membrane transport http://purl.obolibrary.org/obo/GO_0071994 GO:0071993 biolink:BiologicalProcess phytochelatin transport The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. go.json cadystin transport http://purl.obolibrary.org/obo/GO_0071993 GO:0071992 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071992 GO:0071991 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071991 GO:0140382 biolink:MolecularActivity tryptamine 4-monooxygenase activity Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O. EC:1.14.99.59|RHEA:15865 go.json http://purl.obolibrary.org/obo/GO_0140382 GO:0140381 biolink:MolecularActivity 4-hydroxytryptamine 4-phosphate methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin. EC:2.1.1.345|RHEA:55568 go.json norbaeocystin methyltransferase|psilocybin synthase http://purl.obolibrary.org/obo/GO_0140381 GO:0140384 biolink:BiologicalProcess metacyclogenesis The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania. go.json http://purl.obolibrary.org/obo/GO_0140384 GO:0140383 biolink:MolecularActivity 4-hydroxytryptamine kinase activity Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+. EC:2.7.1.222|RHEA:55564 go.json http://purl.obolibrary.org/obo/GO_0140383 GO:0140380 biolink:BiologicalProcess psilocybin biosynthetic process The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product. go.json http://purl.obolibrary.org/obo/GO_0140380 GO:0140373 biolink:BiologicalProcess obsolete histone H3-K14 ubiquitination OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone. go.json histone H3 ubiquitination at K14|histone H3-K14 ubiquitylation|histone H3K14 ubiquitination True http://purl.obolibrary.org/obo/GO_0140373 GO:0140372 biolink:BiologicalProcess obsolete histone H3 ubiquitination OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups. go.json histone H3 ubiquitylation True http://purl.obolibrary.org/obo/GO_0140372 GO:0140375 biolink:MolecularActivity immune receptor activity Receiving a signal and transmitting it in a cell to initiate an immune response. go.json http://purl.obolibrary.org/obo/GO_0140375 GO:0140374 biolink:BiologicalProcess antiviral innate immune response A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. go.json http://purl.obolibrary.org/obo/GO_0140374 GO:0140376 biolink:MolecularActivity innate immune receptor activity Receiving a signal and transmitting it in a cell to initiate an innate immune response. go.json http://purl.obolibrary.org/obo/GO_0140376 GO:0140393 biolink:MolecularActivity norsolorinic acid ketoreductase activity Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH. EC:1.1.1.349|KEGG_REACTION:R10309|MetaCyc:RXN-9480|RHEA:35447 go.json http://purl.obolibrary.org/obo/GO_0140393 GO:0140395 biolink:MolecularActivity averantin hydroxylase activity Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis. EC:1.14.14.116|MetaCyc:RXN-9482|RHEA:35575 go.json http://purl.obolibrary.org/obo/GO_0140395 GO:0140394 biolink:MolecularActivity ABC-type azole transporter activity Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out). RHEA:33503 go.json ATPase-coupled azole transmembrane transporter activity|azole ABC transporter activity http://purl.obolibrary.org/obo/GO_0140394 GO:0140397 biolink:MolecularActivity versiconal hemiacetal acetate esterase activity Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate. EC:3.1.1.94|MetaCyc:RXN-9488|MetaCyc:RXN-9493|RHEA:35715 go.json http://purl.obolibrary.org/obo/GO_0140397 GO:0140396 biolink:MolecularActivity 5'-hydroxyaverantin dehydrogenase activity Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH. EC:1.1.1.352|RHEA:35475 go.json http://purl.obolibrary.org/obo/GO_0140396 GO:0140399 biolink:MolecularActivity aflatoxin B synthase activity Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 = aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2). EC:1.14.14.117|MetaCyc:RXN-9497|MetaCyc:RXN-9502|RHEA:35759 go.json http://purl.obolibrary.org/obo/GO_0140399 GO:0140398 biolink:MolecularActivity versicolorin B desaturase activity Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. KEGG_REACTION:R10479|MetaCyc:RXN-9495|RHEA:35743 go.json http://purl.obolibrary.org/obo/GO_0140398 GO:0032559 biolink:MolecularActivity adenyl ribonucleotide binding Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032559 GO:0032558 biolink:MolecularActivity adenyl deoxyribonucleotide binding Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032558 GO:0032557 biolink:MolecularActivity pyrimidine ribonucleotide binding Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032557 GO:0032556 biolink:MolecularActivity pyrimidine deoxyribonucleotide binding Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032556 GO:0007599 biolink:BiologicalProcess hemostasis The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. Wikipedia:Hemostasis go.json http://purl.obolibrary.org/obo/GO_0007599 GO:0007598 biolink:BiologicalProcess blood coagulation, extrinsic pathway A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X. go.json http://purl.obolibrary.org/obo/GO_0007598 GO:0007597 biolink:BiologicalProcess blood coagulation, intrinsic pathway A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. go.json http://purl.obolibrary.org/obo/GO_0007597 GO:0007596 biolink:BiologicalProcess blood coagulation The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. Wikipedia:Coagulation go.json blood clotting http://purl.obolibrary.org/obo/GO_0007596 GO:0007595 biolink:BiologicalProcess lactation The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. Wikipedia:Lactation go.json milk secretion http://purl.obolibrary.org/obo/GO_0007595 GO:0007594 biolink:BiologicalProcess puparial adhesion The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation. go.json puparial glue http://purl.obolibrary.org/obo/GO_0007594 GO:0007593 biolink:BiologicalProcess chitin-based cuticle sclerotization The process of hardening of a chitin-based cuticle. go.json chitin-based cuticle tanning|cuticle hardening http://purl.obolibrary.org/obo/GO_0007593 GO:0007592 biolink:BiologicalProcess obsolete protein-based cuticle development OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans. go.json protein-based cuticle anabolism|protein-based cuticle biosynthetic process|protein-based cuticle development|protein-based cuticle formation|protein-based cuticle synthesis True http://purl.obolibrary.org/obo/GO_0007592 GO:0032555 biolink:MolecularActivity purine ribonucleotide binding Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032555 GO:0032554 biolink:MolecularActivity purine deoxyribonucleotide binding Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032554 GO:0032553 biolink:MolecularActivity ribonucleotide binding Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032553 GO:0032552 biolink:MolecularActivity deoxyribonucleotide binding Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032552 GO:0032551 biolink:MolecularActivity pyrimidine ribonucleoside binding Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose. go.json http://purl.obolibrary.org/obo/GO_0032551 GO:0032550 biolink:MolecularActivity purine ribonucleoside binding Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose. go.json http://purl.obolibrary.org/obo/GO_0032550 GO:0032549 biolink:MolecularActivity ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. go.json http://purl.obolibrary.org/obo/GO_0032549 GO:0032548 biolink:MolecularActivity pyrimidine deoxyribonucleoside binding Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0032548 GO:0032547 biolink:MolecularActivity purine deoxyribonucleoside binding Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0032547 GO:0032546 biolink:MolecularActivity deoxyribonucleoside binding Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose. go.json http://purl.obolibrary.org/obo/GO_0032546 GO:0032545 biolink:CellularComponent CURI complex A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p. go.json http://purl.obolibrary.org/obo/GO_0032545 GO:0032544 biolink:BiologicalProcess plastid translation The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. go.json plastid protein anabolism|plastid protein biosynthesis|plastid protein formation|plastid protein synthesis|plastid protein translation http://purl.obolibrary.org/obo/GO_0032544 GO:0032543 biolink:BiologicalProcess mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. go.json mitochondrial protein anabolism|mitochondrial protein biosynthesis|mitochondrial protein formation|mitochondrial protein synthesis|mitochondrial protein translation http://purl.obolibrary.org/obo/GO_0032543 goslim_yeast GO:0032542 biolink:MolecularActivity sulfiredoxin activity Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. EC:1.8.98.2|MetaCyc:1.8.98.2-RXN|RHEA:17545|Reactome:R-HSA-9760094 go.json Srx1|peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity|peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]|sulphiredoxin activity http://purl.obolibrary.org/obo/GO_0032542 GO:0032541 biolink:CellularComponent cortical endoplasmic reticulum A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. go.json ER-PM peripheral junction|cortical ER|peripheral ER|peripheral endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0032541 GO:0032540 biolink:BiologicalProcess positive regulation of host-seeking behavior Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism. go.json activation of host-seeking behavior|positive regulation of host-seeking behaviour|stimulation of host-seeking behavior|up regulation of host-seeking behavior|up-regulation of host-seeking behavior|upregulation of host-seeking behavior http://purl.obolibrary.org/obo/GO_0032540 GO:0032539 biolink:BiologicalProcess negative regulation of host-seeking behavior Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism. go.json down regulation of host-seeking behavior|down-regulation of host-seeking behavior|downregulation of host-seeking behavior|inhibition of host-seeking behavior|negative regulation of host-seeking behaviour http://purl.obolibrary.org/obo/GO_0032539 GO:0032538 biolink:BiologicalProcess regulation of host-seeking behavior Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism. go.json regulation of host-seeking behaviour http://purl.obolibrary.org/obo/GO_0032538 GO:0032537 biolink:BiologicalProcess host-seeking behavior The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host. go.json host-seeking behaviour http://purl.obolibrary.org/obo/GO_0032537 GO:0032536 biolink:BiologicalProcess regulation of cell projection size A process that modulates the size of a cell projection. go.json http://purl.obolibrary.org/obo/GO_0032536 GO:0007579 biolink:BiologicalProcess obsolete senescence factor accumulation OBSOLETE. (Was not defined before being made obsolete). go.json senescence factor accumulation True http://purl.obolibrary.org/obo/GO_0007579 GO:0032535 biolink:BiologicalProcess regulation of cellular component size A process that modulates the size of a cellular component. go.json http://purl.obolibrary.org/obo/GO_0032535 GO:0007578 biolink:BiologicalProcess obsolete aging dependent sterility (sensu Saccharomyces) OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes. go.json aging dependent sterility (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007578 GO:0032534 biolink:BiologicalProcess regulation of microvillus assembly A process that modulates the formation of a microvillus. go.json regulation of microvillus biogenesis http://purl.obolibrary.org/obo/GO_0032534 GO:0007577 biolink:BiologicalProcess obsolete autophagic death (sensu Saccharomyces) OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA. go.json autophagic death (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007577 GO:0007576 biolink:BiologicalProcess obsolete nucleolar fragmentation OBSOLETE. The cell aging process that results in the nucleolus breaking down into fragments. go.json nucleolar size increase True http://purl.obolibrary.org/obo/GO_0007576 GO:0007575 biolink:BiologicalProcess obsolete nucleolar size increase OBSOLETE. The process of nucleolar expansion. go.json nucleolar size increase True http://purl.obolibrary.org/obo/GO_0007575 GO:0007574 biolink:BiologicalProcess obsolete cell aging (sensu Saccharomyces) OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell. go.json cell aging (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007574 GO:0007573 biolink:BiologicalProcess obsolete age dependent increased protein content OBSOLETE. (Was not defined before being made obsolete). go.json age dependent increased protein content True http://purl.obolibrary.org/obo/GO_0007573 GO:0007572 biolink:BiologicalProcess obsolete age dependent decreased translational activity OBSOLETE. (Was not defined before being made obsolete). go.json age dependent decreased translational activity True http://purl.obolibrary.org/obo/GO_0007572 GO:0007571 biolink:BiologicalProcess obsolete age-dependent general metabolic decline OBSOLETE. A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis. go.json age-dependent decreased translational activity|age-dependent increased protein content|age-dependent yeast cell size increase|nucleolar size increase True http://purl.obolibrary.org/obo/GO_0007571 GO:0007570 biolink:BiologicalProcess obsolete age dependent accumulation of genetic damage OBSOLETE. (Was not defined before being made obsolete). go.json age dependent accumulation of genetic damage True http://purl.obolibrary.org/obo/GO_0007570 GO:0007580 biolink:BiologicalProcess obsolete extrachromosomal circular DNA accumulation involved in cell aging OBSOLETE. Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication. go.json extrachromosomal circular DNA accumulation during cell ageing|extrachromosomal circular DNA accumulation during cell aging True http://purl.obolibrary.org/obo/GO_0007580 GO:0032533 biolink:BiologicalProcess regulation of follicle cell microvillus length A process that modulates the length of a microvillus on a follicle cell. go.json http://purl.obolibrary.org/obo/GO_0032533 GO:0032532 biolink:BiologicalProcess regulation of microvillus length A process that modulates the length of a microvillus. go.json http://purl.obolibrary.org/obo/GO_0032532 GO:0032531 biolink:BiologicalProcess regulation of follicle cell microvillus organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. go.json regulation of follicle cell microvillus organisation|regulation of follicle cell microvillus organization and biogenesis http://purl.obolibrary.org/obo/GO_0032531 GO:0032530 biolink:BiologicalProcess regulation of microvillus organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. go.json regulation of microvillus organisation|regulation of microvillus organization and biogenesis http://purl.obolibrary.org/obo/GO_0032530 GO:0032529 biolink:BiologicalProcess follicle cell microvillus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments. go.json follicle cell microvillus organisation|follicle cell microvillus organization and biogenesis http://purl.obolibrary.org/obo/GO_0032529 GO:0032528 biolink:BiologicalProcess microvillus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. go.json microvillus organisation|microvillus organization and biogenesis http://purl.obolibrary.org/obo/GO_0032528 GO:0032527 biolink:BiologicalProcess protein exit from endoplasmic reticulum The directed movement of proteins from the endoplasmic reticulum. go.json protein exit from ER|protein export from ER|protein export from endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0032527 GO:0032526 biolink:BiologicalProcess response to retinoic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. go.json response to vitamin A acid http://purl.obolibrary.org/obo/GO_0032526 GO:0032525 biolink:BiologicalProcess somite rostral/caudal axis specification The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary. go.json somite rostrocaudal axis specification|somite rostrocaudal polarity http://purl.obolibrary.org/obo/GO_0032525 GO:0032524 biolink:BiologicalProcess obsolete nutrient export OBSOLETE. The directed movement of nutrients out of a cell or organelle. go.json nutrient export True http://purl.obolibrary.org/obo/GO_0032524 GO:0032523 biolink:MolecularActivity silicon efflux transmembrane transporter activity Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane. go.json silicon efflux transporter activity http://purl.obolibrary.org/obo/GO_0032523 GO:0007589 biolink:BiologicalProcess body fluid secretion The controlled release of a fluid by a cell or tissue in an animal. go.json http://purl.obolibrary.org/obo/GO_0007589 GO:0007588 biolink:BiologicalProcess excretion The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. Wikipedia:Excretion go.json http://purl.obolibrary.org/obo/GO_0007588 gocheck_do_not_annotate|goslim_pir GO:0007587 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007587 GO:0007586 biolink:BiologicalProcess digestion The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. Wikipedia:Digestion go.json http://purl.obolibrary.org/obo/GO_0007586 goslim_chembl|goslim_pir GO:0007585 biolink:BiologicalProcess respiratory gaseous exchange by respiratory system The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. go.json breathing|respiration http://purl.obolibrary.org/obo/GO_0007585 goslim_chembl GO:0007584 biolink:BiologicalProcess response to nutrient Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. go.json nutritional response pathway|response to nutrients http://purl.obolibrary.org/obo/GO_0007584 GO:0007583 biolink:BiologicalProcess obsolete killer activity OBSOLETE. (Was not defined before being made obsolete). go.json killer activity True http://purl.obolibrary.org/obo/GO_0007583 GO:0007582 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007582 GO:0007581 biolink:BiologicalProcess obsolete age-dependent yeast cell size increase OBSOLETE. (Was not defined before being made obsolete). go.json age-dependent yeast cell size increase True http://purl.obolibrary.org/obo/GO_0007581 GO:0007591 biolink:BiologicalProcess molting cycle, chitin-based cuticle The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster. go.json chitin-based cuticle molting cycle http://purl.obolibrary.org/obo/GO_0007591 GO:0007590 biolink:BiologicalProcess obsolete fat body metabolic process (sensu Insecta) OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). go.json fat body metabolic process (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0007590 GO:0032522 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032522 GO:0032521 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032521 GO:0032520 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032520 GO:0032519 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032519 GO:0032518 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032518 GO:0032517 biolink:CellularComponent SOD1-calcineurin complex A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1. go.json http://purl.obolibrary.org/obo/GO_0032517 GO:0032516 biolink:BiologicalProcess positive regulation of phosphoprotein phosphatase activity Any process that activates or increases the activity of a phosphoprotein phosphatase. go.json activation of calcineurin activity|activation of phosphoprotein phosphatase activity|activation of protein phosphatase 3 activity|activation of protein phosphatase type 2A activity|activation of protein phosphatase type 2B activity|calcineurin activation|positive regulation of calcineurin activity|positive regulation of protein phosphatase 2 activity|positive regulation of protein phosphatase 3 activity|positive regulation of protein phosphatase type 2A activity|positive regulation of protein phosphatase type 2B activity|stimulation of phosphoprotein phosphatase activity|stimulation of protein phosphatase 2 activity|stimulation of protein phosphatase type 2A activity|stimulation of protein phosphatase type 2B activity|up regulation of calcineurin activity|up regulation of phosphoprotein phosphatase activity|up regulation of protein phosphatase 2 activity|up regulation of protein phosphatase 3 activity|up regulation of protein phosphatase type 2A activity|up regulation of protein phosphatase type 2B activity|up-regulation of phosphoprotein phosphatase activity|up-regulation of protein phosphatase 2 activity|up-regulation of protein phosphatase type 2A activity|up-regulation of protein phosphatase type 2B activity|upregulation of phosphoprotein phosphatase activity|upregulation of protein phosphatase 2 activity|upregulation of protein phosphatase type 2A activity|upregulation of protein phosphatase type 2B activity http://purl.obolibrary.org/obo/GO_0032516 gocheck_do_not_annotate GO:0032515 biolink:BiologicalProcess negative regulation of phosphoprotein phosphatase activity Any process that stops or reduces the activity of a phosphoprotein phosphatase. go.json down regulation of calcineurin activity|down regulation of phosphoprotein phosphatase activity|down regulation of protein phosphatase 2 activity|down regulation of protein phosphatase 3 activity|down regulation of protein phosphatase type 2A activity|down regulation of protein phosphatase type 2B activity|down-regulation of phosphoprotein phosphatase activity|down-regulation of protein phosphatase type 2A activity|down-regulation of protein phosphatase type 2B activity|downregulation of calcineurin activity|downregulation of phosphoprotein phosphatase activity|downregulation of protein phosphatase 2 activity|downregulation of protein phosphatase 3 activity|downregulation of protein phosphatase type 2A activity|downregulation of protein phosphatase type 2B activity|inhibition of calcineurin activity|inhibition of phosphoprotein phosphatase activity|inhibition of protein phosphatase 2 activity|inhibition of protein phosphatase 3 activity|inhibition of protein phosphatase type 2A activity|inhibition of protein phosphatase type 2B activity|negative regulation of calcineurin activity|negative regulation of protein phosphatase 2 activity|negative regulation of protein phosphatase type 2A activity|negative regulation of protein phosphatase type 2B activity|regulation of protein phosphatase 3 activity http://purl.obolibrary.org/obo/GO_0032515 gocheck_do_not_annotate GO:0007559 biolink:BiologicalProcess obsolete histolysis OBSOLETE. The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue. Wikipedia:Histolysis go.json True http://purl.obolibrary.org/obo/GO_0007559 GO:0007558 biolink:BiologicalProcess regulation of juvenile hormone secretion Any process that modulates the frequency, rate or extent of juvenile hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0007558 GO:0032514 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032514 GO:0007557 biolink:BiologicalProcess regulation of juvenile hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. go.json regulation of juvenile hormone anabolism|regulation of juvenile hormone biosynthesis|regulation of juvenile hormone formation|regulation of juvenile hormone synthesis http://purl.obolibrary.org/obo/GO_0007557 GO:0032513 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032513 GO:0007556 biolink:BiologicalProcess regulation of juvenile hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. go.json regulation of juvenile hormone metabolism http://purl.obolibrary.org/obo/GO_0007556 GO:0032512 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032512 GO:0007555 biolink:BiologicalProcess regulation of ecdysteroid secretion Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell. go.json http://purl.obolibrary.org/obo/GO_0007555 GO:0007554 biolink:BiologicalProcess regulation of ecdysteroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. go.json regulation of ecdysteroid anabolism|regulation of ecdysteroid biosynthesis|regulation of ecdysteroid formation|regulation of ecdysteroid synthesis http://purl.obolibrary.org/obo/GO_0007554 GO:0007553 biolink:BiologicalProcess regulation of ecdysteroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. go.json regulation of ecdysteroid metabolism http://purl.obolibrary.org/obo/GO_0007553 GO:0007552 biolink:BiologicalProcess metamorphosis A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster. Wikipedia:Metamorphosis go.json http://purl.obolibrary.org/obo/GO_0007552 GO:0007551 biolink:BiologicalProcess obsolete maintenance of dosage compensation OBSOLETE. (Was not defined before being made obsolete). go.json maintenance of dosage compensation True http://purl.obolibrary.org/obo/GO_0007551 GO:0007550 biolink:BiologicalProcess obsolete establishment of dosage compensation OBSOLETE. (Was not defined before being made obsolete). go.json establishment of dosage compensation True http://purl.obolibrary.org/obo/GO_0007550 GO:0032511 biolink:BiologicalProcess late endosome to vacuole transport via multivesicular body sorting pathway The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. go.json endosome to vacuole transport via MVB sorting pathway http://purl.obolibrary.org/obo/GO_0032511 GO:0032510 biolink:BiologicalProcess endosome to lysosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. go.json endosome to lysosome transport via MVB sorting pathway http://purl.obolibrary.org/obo/GO_0032510 GO:0032508 biolink:BiologicalProcess DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. go.json DNA unwinding|duplex DNA melting http://purl.obolibrary.org/obo/GO_0032508 GO:0032507 biolink:BiologicalProcess maintenance of protein location in cell Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. go.json maintenance of protein localization in cell http://purl.obolibrary.org/obo/GO_0032507 GO:0032506 biolink:BiologicalProcess cytokinetic process A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). go.json http://purl.obolibrary.org/obo/GO_0032506 GO:0032505 biolink:BiologicalProcess reproduction of a single-celled organism The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. go.json http://purl.obolibrary.org/obo/GO_0032505 GO:0032504 biolink:BiologicalProcess multicellular organism reproduction The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. go.json http://purl.obolibrary.org/obo/GO_0032504 goslim_drosophila GO:0007569 biolink:BiologicalProcess obsolete cell aging OBSOLETE. An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). go.json cell ageing True http://purl.obolibrary.org/obo/GO_0007569 GO:0032503 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032503 GO:0032502 biolink:BiologicalProcess developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. go.json development|single-organism developmental process http://purl.obolibrary.org/obo/GO_0032502 goslim_agr|goslim_flybase_ribbon|goslim_pir GO:0007568 biolink:BiologicalProcess obsolete aging OBSOLETE. A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). go.json ageing True http://purl.obolibrary.org/obo/GO_0007568 GO:0032501 biolink:BiologicalProcess multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. go.json organismal physiological process|single-multicellular organism process http://purl.obolibrary.org/obo/GO_0032501 gocheck_do_not_annotate|goslim_pir GO:0007567 biolink:BiologicalProcess parturition The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. go.json egg laying|giving birth http://purl.obolibrary.org/obo/GO_0007567 GO:0007566 biolink:BiologicalProcess embryo implantation Attachment of the blastocyst to the uterine lining. go.json blastocyst implantation http://purl.obolibrary.org/obo/GO_0007566 GO:0007565 biolink:BiologicalProcess female pregnancy The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. Wikipedia:Gestation go.json carrying of young|gestation http://purl.obolibrary.org/obo/GO_0007565 goslim_chembl GO:0007564 biolink:BiologicalProcess regulation of chitin-based cuticle tanning Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning. go.json regulation of cuticle hardening|regulation of cuticle tanning http://purl.obolibrary.org/obo/GO_0007564 GO:0007563 biolink:BiologicalProcess regulation of eclosion Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg. go.json http://purl.obolibrary.org/obo/GO_0007563 GO:0007562 biolink:BiologicalProcess eclosion The emergence of an adult insect from a pupa case. Wikipedia:Pupa#Emergence go.json http://purl.obolibrary.org/obo/GO_0007562 GO:0007561 biolink:BiologicalProcess imaginal disc eversion The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis. go.json http://purl.obolibrary.org/obo/GO_0007561 GO:0007560 biolink:BiologicalProcess imaginal disc morphogenesis The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. go.json imaginal disc metamorphosis http://purl.obolibrary.org/obo/GO_0007560 GO:0032509 biolink:BiologicalProcess endosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. go.json endosome transport via MVB sorting pathway http://purl.obolibrary.org/obo/GO_0032509 GO:0032500 biolink:MolecularActivity muramyl dipeptide binding Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0032500 GO:0007539 biolink:BiologicalProcess primary sex determination, soma The transmission of information about sexual status from the initial, general, determination to signals specific to the soma. go.json http://purl.obolibrary.org/obo/GO_0007539 GO:0007538 biolink:BiologicalProcess primary sex determination The sex determination process that results in the initial specification of sexual status of an individual organism. go.json http://purl.obolibrary.org/obo/GO_0007538 GO:0007537 biolink:BiologicalProcess inactivation of recombination (HML) The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0007537 GO:0007536 biolink:BiologicalProcess activation of recombination (HML) The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. go.json http://purl.obolibrary.org/obo/GO_0007536 GO:0007535 biolink:BiologicalProcess donor selection The process that determines which donor locus a cell uses, in preference to another, in mating type switching. go.json donor preference http://purl.obolibrary.org/obo/GO_0007535 GO:0007534 biolink:BiologicalProcess gene conversion at mating-type locus The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged. go.json gene conversion at mating-type locus, DNA double-strand break formation|gene conversion at mating-type locus, DNA double-strand break processing|gene conversion at mating-type locus, DNA repair synthesis|gene conversion at mating-type locus, termination of copy-synthesis|heteroduplex formation involved in gene conversion at mating-type locus|strand invasion involved in gene conversion at mating-type locus http://purl.obolibrary.org/obo/GO_0007534 GO:0007533 biolink:BiologicalProcess mating type switching The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. go.json mating type switching and recombination http://purl.obolibrary.org/obo/GO_0007533 GO:0007532 biolink:BiologicalProcess regulation of mating-type specific transcription, DNA-templated Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription. go.json mating-type specific transcriptional control|regulation of mating-type specific transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0007532 GO:0007531 biolink:BiologicalProcess mating type determination Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms. go.json http://purl.obolibrary.org/obo/GO_0007531 GO:0007530 biolink:BiologicalProcess sex determination Any process that establishes and transmits the specification of sexual status of an individual organism. Wikipedia:Sex-determination_system go.json http://purl.obolibrary.org/obo/GO_0007530 GO:0007549 biolink:BiologicalProcess sex-chromosome dosage compensation Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes. Wikipedia:Sex-chromosome_dosage_compensation go.json dosage compensation|sex chromosome dosage compensation http://purl.obolibrary.org/obo/GO_0007549 GO:0007548 biolink:BiologicalProcess sex differentiation The establishment of the sex of an organism by physical differentiation. Wikipedia:Sexual_differentiation go.json http://purl.obolibrary.org/obo/GO_0007548 GO:0007547 biolink:BiologicalProcess germ-line processes downstream of sex determination signal The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways. go.json http://purl.obolibrary.org/obo/GO_0007547 GO:0007546 biolink:BiologicalProcess somatic processes downstream of sex determination signal The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways. go.json http://purl.obolibrary.org/obo/GO_0007546 GO:0007545 biolink:BiologicalProcess processes downstream of sex determination signal The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways. go.json http://purl.obolibrary.org/obo/GO_0007545 GO:0007544 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007544 GO:0007543 biolink:BiologicalProcess sex determination, somatic-gonadal interaction The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism. go.json sex determination, somatic/gonadal interaction http://purl.obolibrary.org/obo/GO_0007543 GO:0007542 biolink:BiologicalProcess primary sex determination, germ-line The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line. go.json http://purl.obolibrary.org/obo/GO_0007542 GO:0007541 biolink:BiologicalProcess sex determination, primary response to X:A ratio The developmental process in which an organism interprets its X to autosomal chromosomal complement. go.json http://purl.obolibrary.org/obo/GO_0007541 GO:0007540 biolink:BiologicalProcess sex determination, establishment of X:A ratio The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it. go.json http://purl.obolibrary.org/obo/GO_0007540 GO:0032591 biolink:CellularComponent dendritic spine membrane The portion of the plasma membrane surrounding a dendritic spine. go.json http://purl.obolibrary.org/obo/GO_0032591 GO:0032590 biolink:CellularComponent dendrite membrane The portion of the plasma membrane surrounding a dendrite. go.json http://purl.obolibrary.org/obo/GO_0032590 GO:0032599 biolink:BiologicalProcess protein transport out of membrane raft The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. go.json protein translocation out of membrane raft|protein transport out of lipid raft|receptor translocation out of membrane raft|receptor transport out of membrane raft http://purl.obolibrary.org/obo/GO_0032599 GO:0032598 biolink:BiologicalProcess B cell receptor transport into immunological synapse The directed movement of a B cell receptor into an immunological synapse. go.json B cell receptor translocation into immunological synapse|BCR translocation into immunological synapse|BCR transport into immunological synapse http://purl.obolibrary.org/obo/GO_0032598 GO:0032597 biolink:BiologicalProcess B cell receptor transport into membrane raft The directed movement of a B cell receptor into a membrane raft. go.json B cell receptor translocation into membrane raft|B cell receptor transport into lipid raft|BCR translocation into membrane raft|BCR transport into membrane raft http://purl.obolibrary.org/obo/GO_0032597 GO:0032596 biolink:BiologicalProcess protein transport into membrane raft The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. go.json protein translocation into membrane raft|protein transport into lipid raft|receptor translocation into membrane raft|receptor transport into membrane raft http://purl.obolibrary.org/obo/GO_0032596 GO:0032595 biolink:BiologicalProcess B cell receptor transport within lipid bilayer The directed movement of a B cell receptor within a lipid bilayer. go.json B cell receptor translocation within membrane|BCR translocation within membrane|BCR transport within lipid bilayer http://purl.obolibrary.org/obo/GO_0032595 GO:0032594 biolink:BiologicalProcess protein transport within lipid bilayer The directed movement of a protein from one location to another within a lipid bilayer. go.json protein translocation within membrane|receptor translocation within membrane|receptor transport within lipid bilayer http://purl.obolibrary.org/obo/GO_0032594 GO:0032593 biolink:CellularComponent insulin-responsive compartment A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. go.json GLUT4 storage compartment|GSC|IRC http://purl.obolibrary.org/obo/GO_0032593 GO:0032592 biolink:CellularComponent obsolete integral component of mitochondrial membrane OBSOLETE. The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to mitochondrial membrane True http://purl.obolibrary.org/obo/GO_0032592 GO:0032589 biolink:CellularComponent neuron projection membrane The portion of the plasma membrane surrounding a neuron projection. go.json http://purl.obolibrary.org/obo/GO_0032589 GO:0032580 biolink:CellularComponent Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. go.json Golgi apparatus cisterna membrane|Golgi stack membrane http://purl.obolibrary.org/obo/GO_0032580 GO:0032588 biolink:CellularComponent trans-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. go.json Golgi trans face membrane|trans Golgi network membrane http://purl.obolibrary.org/obo/GO_0032588 GO:0032587 biolink:CellularComponent ruffle membrane The portion of the plasma membrane surrounding a ruffle. go.json membrane ruffle http://purl.obolibrary.org/obo/GO_0032587 GO:0032586 biolink:CellularComponent protein storage vacuole membrane The lipid bilayer surrounding a protein storage vacuole. go.json http://purl.obolibrary.org/obo/GO_0032586 GO:0032585 biolink:CellularComponent multivesicular body membrane The lipid bilayer surrounding a multivesicular body. go.json MVB membrane|MVE membrane|multivesicular endosome membrane http://purl.obolibrary.org/obo/GO_0032585 GO:0032584 biolink:CellularComponent growth cone membrane The portion of the plasma membrane surrounding a growth cone. go.json http://purl.obolibrary.org/obo/GO_0032584 GO:0032583 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032583 GO:0032582 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032582 GO:0032581 biolink:BiologicalProcess ER-dependent peroxisome organization A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum. go.json ER-dependent peroxisome biogenesis|ER-dependent peroxisome organisation|endoplasmic reticulum-dependent peroxisome organization http://purl.obolibrary.org/obo/GO_0032581 GO:0032579 biolink:CellularComponent apical lamina of hyaline layer A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms. go.json http://purl.obolibrary.org/obo/GO_0032579 GO:0032578 biolink:CellularComponent aleurone grain membrane The lipid bilayer surrounding an aleurone grain. go.json http://purl.obolibrary.org/obo/GO_0032578 GO:0032577 biolink:MolecularActivity phosphatidylcholine:cardiolipin O-linoleoyltransferase activity Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule. go.json phosphatidylcholine:cardiolipin linoleoyltransferase http://purl.obolibrary.org/obo/GO_0032577 GO:0032576 biolink:MolecularActivity O-linoleoyltransferase activity Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0032576 GO:0032575 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032575 GO:0032574 biolink:MolecularActivity 5'-3' RNA helicase activity Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis. Reactome:R-HSA-9682695|Reactome:R-HSA-9694265 go.json 5' to 3' RNA helicase activity|ATP-dependent 5' to 3' RNA helicase activity|ATP-dependent 5'-3' RNA helicase activity http://purl.obolibrary.org/obo/GO_0032574 GO:0032573 biolink:BiologicalProcess response to phylloquinone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus. go.json response to vitamin K1 http://purl.obolibrary.org/obo/GO_0032573 GO:0032572 biolink:BiologicalProcess response to menaquinone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus. go.json response to menatetrenone|response to vitamin K2 http://purl.obolibrary.org/obo/GO_0032572 GO:0032571 biolink:BiologicalProcess response to vitamin K Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. go.json http://purl.obolibrary.org/obo/GO_0032571 GO:0032570 biolink:BiologicalProcess response to progesterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. go.json response to progesterone stimulus http://purl.obolibrary.org/obo/GO_0032570 GO:0032569 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032569 GO:0032568 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032568 GO:0032567 biolink:MolecularActivity dGTP binding Binding to dGTP, deoxyguanosine triphosphate. go.json http://purl.obolibrary.org/obo/GO_0032567 GO:0032566 biolink:MolecularActivity dGDP binding Binding to dGDP, deoxyguanosine diphosphate. go.json http://purl.obolibrary.org/obo/GO_0032566 GO:0032565 biolink:MolecularActivity dGMP binding Binding to dGMP, deoxyguanosine monophosphate. go.json http://purl.obolibrary.org/obo/GO_0032565 GO:0032564 biolink:MolecularActivity dATP binding Binding to dATP, deoxyadenosine triphosphate. go.json http://purl.obolibrary.org/obo/GO_0032564 GO:0032563 biolink:MolecularActivity dADP binding Binding to dADP, deoxyadenosine diphosphate. go.json http://purl.obolibrary.org/obo/GO_0032563 GO:0032562 biolink:MolecularActivity dAMP binding Binding to dAMP, deoxyadenosine monophosphate. go.json http://purl.obolibrary.org/obo/GO_0032562 GO:0032561 biolink:MolecularActivity guanyl ribonucleotide binding Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032561 GO:0032560 biolink:MolecularActivity guanyl deoxyribonucleotide binding Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. go.json http://purl.obolibrary.org/obo/GO_0032560 GO:0140225 biolink:CellularComponent DNA topoisomerase III-beta-TDRD3 complex A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities. go.json Top3-beta-TDRD3 complex http://purl.obolibrary.org/obo/GO_0140225 GO:0140224 biolink:CellularComponent SLAC complex A protein complex that regulates Arp2/3 complex-mediated actin nucleation. go.json http://purl.obolibrary.org/obo/GO_0140224 GO:0140227 biolink:BiologicalProcess serotonin-gated cation-selective signaling pathway The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. go.json 5-HT-gated cation-selective signaling pathway|5-HT-gated cation-selective signalling pathway|5-hydroxytryptamine-gated cation-selective signaling pathway|5-hydroxytryptamine-gated cation-selective signalling pathway|serotonin-gated cation-selective signalling pathway http://purl.obolibrary.org/obo/GO_0140227 GO:0140226 biolink:MolecularActivity RNA topoisomerase activity Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA. go.json http://purl.obolibrary.org/obo/GO_0140226 GO:0140221 biolink:CellularComponent pathogen-containing vacuole membrane Host-derived membrane of a pathogen-containing vacuole. go.json pathogen inclusion membrane|pathogen-containing compartment membrane http://purl.obolibrary.org/obo/GO_0140221 GO:0140220 biolink:CellularComponent pathogen-containing vacuole A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides. go.json pathogen inclusion|pathogen-containing compartment http://purl.obolibrary.org/obo/GO_0140220 GO:0140223 biolink:MolecularActivity general transcription initiation factor activity A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. go.json GTF activity|basal transcription factor activity|general transcription factor activity http://purl.obolibrary.org/obo/GO_0140223 goslim_drosophila|goslim_generic GO:0140222 biolink:CellularComponent pathogen-containing vacuole lumen The enclosed volume within the sealed membrane of a pathogen-containing vacuole. go.json lumen of a pathogen-containing vacuole|pathogen inclusion lumen|pathogen-containing compartment lumen|pathogen-containing vacuolar lumen http://purl.obolibrary.org/obo/GO_0140222 GO:0140214 biolink:BiologicalProcess positive regulation of long-chain fatty acid import into cell Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell. go.json http://purl.obolibrary.org/obo/GO_0140214 GO:0140213 biolink:BiologicalProcess negative regulation of long-chain fatty acid import into cell Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell. go.json http://purl.obolibrary.org/obo/GO_0140213 GO:0140216 biolink:BiologicalProcess negative regulation of D-aspartate import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140216 GO:0140215 biolink:BiologicalProcess regulation of D-aspartate import across plasma membrane Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140215 GO:0140217 biolink:BiologicalProcess positive regulation of D-aspartate import across plasma membrane Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140217 GO:0140210 biolink:BiologicalProcess protein transport along microtubule to kinetochore Any process in which a protein is transported to the kinetochore along a microtubule. go.json http://purl.obolibrary.org/obo/GO_0140210 GO:0140212 biolink:BiologicalProcess regulation of long-chain fatty acid import into cell Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell. go.json http://purl.obolibrary.org/obo/GO_0140212 GO:0140211 biolink:MolecularActivity folic acid:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid. TC:2.A.1.50.1 go.json http://purl.obolibrary.org/obo/GO_0140211 GO:0140247 biolink:BiologicalProcess protein catabolic process at presynapse The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. go.json http://purl.obolibrary.org/obo/GO_0140247 goslim_synapse GO:0140246 biolink:BiologicalProcess protein catabolic process at synapse The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. go.json http://purl.obolibrary.org/obo/GO_0140246 goslim_synapse GO:0140249 biolink:BiologicalProcess protein catabolic process at postsynapse The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0140249 goslim_synapse GO:0140241 biolink:BiologicalProcess translation at synapse Translation that occurs at the synapse. go.json http://purl.obolibrary.org/obo/GO_0140241 goslim_synapse GO:0140240 biolink:CellularComponent perforant pathway to dendrate granule cell synapse A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus. go.json perforant pathway to DG granule cell synapse http://purl.obolibrary.org/obo/GO_0140240 goslim_synapse GO:0140243 biolink:BiologicalProcess regulation of translation at synapse Any process that regulates translation occurring at the synapse. go.json http://purl.obolibrary.org/obo/GO_0140243 goslim_synapse GO:0140242 biolink:BiologicalProcess translation at postsynapse Translation that occurs at the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0140242 goslim_synapse GO:0140245 biolink:BiologicalProcess regulation of translation at postsynapse Any process that regulates translation occurring at the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0140245 goslim_synapse GO:0140244 biolink:BiologicalProcess regulation of translation at presynapse Any process that regulates translation occurring at the presynapse. go.json http://purl.obolibrary.org/obo/GO_0140244 goslim_synapse GO:0140236 biolink:BiologicalProcess translation at presynapse Translation that occurs at the presynapse. go.json http://purl.obolibrary.org/obo/GO_0140236 goslim_synapse GO:0140235 biolink:BiologicalProcess RNA polyadenylation at postsynapse A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0140235 goslim_synapse GO:0140238 biolink:BiologicalProcess presynaptic endocytosis A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. go.json http://purl.obolibrary.org/obo/GO_0140238 goslim_synapse GO:0140237 biolink:BiologicalProcess translation at presynapse, modulating chemical synaptic transmission Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0140237 goslim_synapse GO:0140239 biolink:BiologicalProcess postsynaptic endocytosis A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. go.json http://purl.obolibrary.org/obo/GO_0140239 goslim_synapse GO:0140232 biolink:MolecularActivity intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential. go.json intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential http://purl.obolibrary.org/obo/GO_0140232 goslim_synapse GO:0140231 biolink:BiologicalProcess anterograde axonal transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons. go.json http://purl.obolibrary.org/obo/GO_0140231 goslim_synapse GO:0140233 biolink:MolecularActivity intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential. go.json intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential http://purl.obolibrary.org/obo/GO_0140233 goslim_synapse GO:0140203 biolink:BiologicalProcess spermidine import across plasma membrane The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140203 GO:0140202 biolink:BiologicalProcess polyamine import across plasma membrane The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140202 GO:0140205 biolink:BiologicalProcess oligopeptide import across plasma membrane The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140205 GO:0140204 biolink:BiologicalProcess pyridoxal import across plasma membrane The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140204 GO:0140207 biolink:BiologicalProcess tripeptide import across plasma membrane The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140207 GO:0140206 biolink:BiologicalProcess dipeptide import across plasma membrane The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140206 GO:0140209 biolink:BiologicalProcess zinc ion import into endoplasmic reticulum The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum. go.json zinc ion import across endoplasmic reticulum|zinc ion import into ER|zinc(2+) import across endoplasmic reticulum|zinc(2+) import into endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0140209 GO:0140208 biolink:BiologicalProcess apoptotic process in response to mitochondrial fragmentation Any apoptotic process that occurs as a result of mitochondrial fragmentation. go.json apoptosis in response to mitochondrial fragmentation http://purl.obolibrary.org/obo/GO_0140208 GO:0140201 biolink:BiologicalProcess urea import across plasma membrane The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140201 GO:0140200 biolink:BiologicalProcess adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction. go.json http://purl.obolibrary.org/obo/GO_0140200 GO:0007519 biolink:BiologicalProcess skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. go.json myogenesis http://purl.obolibrary.org/obo/GO_0007519 GO:0007518 biolink:BiologicalProcess myoblast fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0007518 GO:0007517 biolink:BiologicalProcess muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. go.json http://purl.obolibrary.org/obo/GO_0007517 GO:0007516 biolink:BiologicalProcess hemocyte development The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. go.json arthropod blood cell development http://purl.obolibrary.org/obo/GO_0007516 GO:0007515 biolink:BiologicalProcess obsolete lymph gland development OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system. go.json lymph gland development True http://purl.obolibrary.org/obo/GO_0007515 GO:1900998 biolink:BiologicalProcess nitrobenzene catabolic process The chemical reactions and pathways resulting in the breakdown of nitrobenzene. go.json nitrobenzene breakdown|nitrobenzene catabolism|nitrobenzene degradation http://purl.obolibrary.org/obo/GO_1900998 GO:1900997 biolink:BiologicalProcess benzene biosynthetic process The chemical reactions and pathways resulting in the formation of benzene. go.json benzene anabolism|benzene biosynthesis|benzene formation|benzene synthesis http://purl.obolibrary.org/obo/GO_1900997 GO:0007514 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007514 GO:0007513 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007513 GO:0007512 biolink:BiologicalProcess adult heart development The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. go.json adult cardiac development http://purl.obolibrary.org/obo/GO_0007512 GO:1900999 biolink:BiologicalProcess nitrobenzene biosynthetic process The chemical reactions and pathways resulting in the formation of nitrobenzene. go.json nitrobenzene anabolism|nitrobenzene biosynthesis|nitrobenzene formation|nitrobenzene synthesis http://purl.obolibrary.org/obo/GO_1900999 GO:1900994 biolink:BiologicalProcess (-)-secologanin biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-secologanin. go.json (-)-secologanin anabolism|(-)-secologanin biosynthesis|(-)-secologanin formation|(-)-secologanin synthesis http://purl.obolibrary.org/obo/GO_1900994 GO:0007511 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007511 GO:1900993 biolink:BiologicalProcess (-)-secologanin catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-secologanin. go.json (-)-secologanin breakdown|(-)-secologanin catabolism|(-)-secologanin degradation http://purl.obolibrary.org/obo/GO_1900993 GO:0007510 biolink:BiologicalProcess cardioblast cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. go.json http://purl.obolibrary.org/obo/GO_0007510 GO:1900996 biolink:BiologicalProcess benzene catabolic process The chemical reactions and pathways resulting in the breakdown of benzene. go.json benzene breakdown|benzene catabolism|benzene degradation http://purl.obolibrary.org/obo/GO_1900996 GO:1900995 biolink:MolecularActivity ubiquinone-6 binding Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2. go.json http://purl.obolibrary.org/obo/GO_1900995 GO:1900990 biolink:BiologicalProcess obsolete scopolamine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of scopolamine. go.json scopolamine breakdown|scopolamine catabolism|scopolamine degradation True http://purl.obolibrary.org/obo/GO_1900990 GO:1900992 biolink:BiologicalProcess (-)-secologanin metabolic process The chemical reactions and pathways involving (-)-secologanin. go.json (-)-secologanin metabolism http://purl.obolibrary.org/obo/GO_1900992 GO:1900991 biolink:BiologicalProcess scopolamine biosynthetic process The chemical reactions and pathways resulting in the formation of scopolamine. go.json scopolamine anabolism|scopolamine biosynthesis|scopolamine formation|scopolamine metabolic process|scopolamine metabolism|scopolamine synthesis http://purl.obolibrary.org/obo/GO_1900991 GO:0007529 biolink:BiologicalProcess establishment of synaptic specificity at neuromuscular junction The biological process in which a synapse between a motor neuron and a muscle is initially formed. go.json http://purl.obolibrary.org/obo/GO_0007529 GO:0007528 biolink:BiologicalProcess neuromuscular junction development A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. go.json NMJ stability|neuromuscular junction organization|neuromuscular junction stability http://purl.obolibrary.org/obo/GO_0007528 GO:0007527 biolink:BiologicalProcess adult somatic muscle development The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007527 GO:0007526 biolink:BiologicalProcess larval somatic muscle development The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007526 GO:0007525 biolink:BiologicalProcess somatic muscle development The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle. go.json http://purl.obolibrary.org/obo/GO_0007525 GO:0007524 biolink:BiologicalProcess adult visceral muscle development The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007524 GO:0007523 biolink:BiologicalProcess larval visceral muscle development The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007523 GO:0007522 biolink:BiologicalProcess visceral muscle development The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007522 GO:0007521 biolink:BiologicalProcess muscle cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0007521 GO:0007520 biolink:BiologicalProcess myoblast fusion A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. go.json http://purl.obolibrary.org/obo/GO_0007520 GO:0140294 biolink:MolecularActivity NAD DNA ADP-ribosyltransferase activity Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. go.json http://purl.obolibrary.org/obo/GO_0140294 GO:0140293 biolink:MolecularActivity ADP-ribosylglutamate hydrolase activity Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose. go.json http://purl.obolibrary.org/obo/GO_0140293 GO:0140296 biolink:MolecularActivity general transcription initiation factor binding Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. go.json http://purl.obolibrary.org/obo/GO_0140296 GO:0140295 biolink:MolecularActivity pathogen-derived receptor ligand activity The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity. go.json host-selective toxin|innate receptor ligand activity|necrotrophic effector http://purl.obolibrary.org/obo/GO_0140295 GO:0140298 biolink:BiologicalProcess endocytic iron import into cell Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis. go.json iron import into cell by endocytosis http://purl.obolibrary.org/obo/GO_0140298 GO:0140297 biolink:MolecularActivity DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. go.json activating transcription factor binding|repressing transcription factor binding|transcription activator binding http://purl.obolibrary.org/obo/GO_0140297 GO:0140299 biolink:MolecularActivity small molecule sensor activity Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. go.json small molecular sensor activity|small molecule sensing activity http://purl.obolibrary.org/obo/GO_0140299 goslim_drosophila|goslim_generic|prokaryote_subset GO:0140290 biolink:BiologicalProcess peptidyl-serine ADP-deribosylation The removal of ADP-ribose from ADP-ribosylserine. go.json http://purl.obolibrary.org/obo/GO_0140290 gocheck_do_not_annotate GO:0140292 biolink:MolecularActivity ADP-ribosylserine hydrolase activity Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose. go.json http://purl.obolibrary.org/obo/GO_0140292 GO:0140291 biolink:BiologicalProcess peptidyl-glutamate ADP-deribosylation The removal of ADP-ribose from ADP-ribosylglutamate. go.json http://purl.obolibrary.org/obo/GO_0140291 gocheck_do_not_annotate GO:0007508 biolink:BiologicalProcess larval heart development The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper. go.json http://purl.obolibrary.org/obo/GO_0007508 GO:0007507 biolink:BiologicalProcess heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. Wikipedia:Heart_development go.json cardiac development|dorsal vessel development http://purl.obolibrary.org/obo/GO_0007507 GO:0007506 biolink:BiologicalProcess gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. go.json http://purl.obolibrary.org/obo/GO_0007506 GO:0007505 biolink:BiologicalProcess adult fat body development The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body. go.json http://purl.obolibrary.org/obo/GO_0007505 GO:0007504 biolink:BiologicalProcess larval fat body development The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life. go.json http://purl.obolibrary.org/obo/GO_0007504 GO:0007503 biolink:BiologicalProcess fat body development The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism. go.json http://purl.obolibrary.org/obo/GO_0007503 GO:0007502 biolink:BiologicalProcess digestive tract mesoderm development The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism. go.json http://purl.obolibrary.org/obo/GO_0007502 GO:0007501 biolink:BiologicalProcess mesodermal cell fate specification The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. go.json mesoderm cell fate specification http://purl.obolibrary.org/obo/GO_0007501 GO:0007500 biolink:BiologicalProcess mesodermal cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json mesoderm cell fate determination http://purl.obolibrary.org/obo/GO_0007500 GO:0007509 biolink:BiologicalProcess mesoderm migration involved in gastrulation The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism. go.json http://purl.obolibrary.org/obo/GO_0007509 GO:0140268 biolink:CellularComponent endoplasmic reticulum-plasma membrane contact site A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes. go.json EPCS|ER-PM contact site|ER-plasma membrane contact site|endoplasmic reticulum-plasma membrane contact junction http://purl.obolibrary.org/obo/GO_0140268 GO:0140261 biolink:CellularComponent BCOR complex A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10. go.json BCL6 corepressor (BCOR) complex|BCOR/BCORL1 complex|PRC1.1 complex|non-canonical BCOR-PRC1.1 complex|non-canonical PRC1-BCOR complex http://purl.obolibrary.org/obo/GO_0140261 GO:0140260 biolink:MolecularActivity mitochondrial proton-transporting ATP synthase complex binding Binding to a mitochondrial proton-transporting ATP synthase complex. go.json http://purl.obolibrary.org/obo/GO_0140260 GO:0140262 biolink:MolecularActivity mRNA cap binding complex binding Binding to a mRNA cap binding complex. go.json http://purl.obolibrary.org/obo/GO_0140262 GO:0140267 biolink:BiologicalProcess viral entry via permeabilization of host membrane The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0140267 gocheck_do_not_annotate GO:0140266 biolink:CellularComponent Woronin body Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes. go.json http://purl.obolibrary.org/obo/GO_0140266 GO:0140259 biolink:MolecularActivity PRC1 complex binding Binding to a PRC1 complex. go.json http://purl.obolibrary.org/obo/GO_0140259 GO:0140250 biolink:BiologicalProcess regulation protein catabolic process at synapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. go.json http://purl.obolibrary.org/obo/GO_0140250 goslim_synapse GO:0140252 biolink:BiologicalProcess regulation protein catabolic process at postsynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0140252 goslim_synapse GO:0140251 biolink:BiologicalProcess regulation protein catabolic process at presynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. go.json http://purl.obolibrary.org/obo/GO_0140251 goslim_synapse GO:0140253 biolink:BiologicalProcess cell-cell fusion A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. go.json cell cell fusion|cell fusion http://purl.obolibrary.org/obo/GO_0140253 GO:0140256 biolink:BiologicalProcess negative regulation of cellular response to phosphate starvation Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation. go.json http://purl.obolibrary.org/obo/GO_0140256 GO:0140255 biolink:BiologicalProcess regulation of cellular response to phosphate starvation Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation. go.json http://purl.obolibrary.org/obo/GO_0140255 GO:0140282 biolink:MolecularActivity carbon-nitrogen ligase activity on lipid II Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate. EC:6.3.5.13|RHEA:57928 go.json L-glutamate--lipid II transaminase activity|undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity http://purl.obolibrary.org/obo/GO_0140282 GO:0140285 biolink:BiologicalProcess endosome fission The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0140285 GO:0140284 biolink:CellularComponent endoplasmic reticulum-endosome membrane contact site A contact site between the endoplasmic reticulum membrane and the endosome membrane. go.json ER-endosome membrane contact site http://purl.obolibrary.org/obo/GO_0140284 GO:0140289 biolink:BiologicalProcess obsolete protein mono-ADP-ribosylation OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids. go.json True http://purl.obolibrary.org/obo/GO_0140289 GO:0140288 biolink:CellularComponent GBAF complex A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM. go.json http://purl.obolibrary.org/obo/GO_0140288 GO:0140281 biolink:BiologicalProcess positive regulation of mitotic division septum assembly Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. go.json activation of division septum formation involved in mitotic cell cycle|activation of formation of division septum involved in mitotic cell cycle|activation of mitotic division septum assembly|activation of septin assembly and septum biosynthesis involved in mitotic cell cycle|activation of septin assembly and septum formation involved in mitotic cell cycle|positive regulation of division septum formation involved in mitotic cell cycle|positive regulation of formation of division septum involved in mitotic cell cycle|positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|positive regulation of septin assembly and septum formation involved in mitotic cell cycle|up regulation of division septum formation involved in mitotic cell cycle|up regulation of formation of division septum involved in mitotic cell cycle|up regulation of mitotic division septum assembly|up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|up regulation of septin assembly and septum formation involved in mitotic cell cycle|up-regulation of division septum formation involved in mitotic cell cycle|up-regulation of formation of division septum involved in mitotic cell cycle|up-regulation of mitotic division septum assembly|up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|up-regulation of septin assembly and septum formation involved in mitotic cell cycle|upregulation of division septum formation involved in mitotic cell cycle|upregulation of formation of division septum involved in mitotic cell cycle|upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|upregulation of septin assembly and septum formation involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_0140281 GO:0140280 biolink:BiologicalProcess negative regulation of mitotic division septum assembly Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. go.json down regulation of division septum formation involved in mitotic cell cycle|down regulation of formation of division septum involved in mitotic cell cycle|down regulation of mitotic division septum assembly|down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|down regulation of septin assembly and septum formation involved in mitotic cell cycle|down-regulation of division septum formation involved in mitotic cell cycle|down-regulation of formation of division septum involved in mitotic cell cycle|down-regulation of mitotic division septum assembly|down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|down-regulation of septin assembly and septum formation involved in mitotic cell cycle|downregulation of division septum formation involved in mitotic cell cycle|downregulation of formation of division septum involved in mitotic cell cycle|downregulation of mitotic division septum assembly|downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|downregulation of septin assembly and septum formation involved in mitotic cell cycle|inhibition of division septum formation involved in mitotic cell cycle|inhibition of formation of division septum involved in mitotic cell cycle|inhibition of mitotic division septum assembly|inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle|inhibition of septin assembly and septum formation involved in mitotic cell cycle|negative regulation of division septum formation involved in mitotic cell cycle|negative regulation of formation of division septum involved in mitotic cell cycle|negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|negative regulation of septin assembly and septum formation involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_0140280 GO:0140279 biolink:BiologicalProcess regulation of mitotic division septum assembly Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. go.json regulation of division septum formation involved in mitotic cell cycle|regulation of formation of division septum involved in mitotic cell cycle|regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle|regulation of septin assembly and septum formation involved in mitotic cell cycle http://purl.obolibrary.org/obo/GO_0140279 GO:0140272 biolink:MolecularActivity exogenous protein binding Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein. go.json http://purl.obolibrary.org/obo/GO_0140272 GO:0140271 biolink:BiologicalProcess hexose import across plasma membrane The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140271 GO:0140274 biolink:BiologicalProcess repair of kinetochore microtubule attachment defect The cell cycle process where kinetochore microtubule attachment defects are corrected. go.json correction of kinetochore microtubule attachment defects|repair of kinetochore microtubule attachment defects http://purl.obolibrary.org/obo/GO_0140274 GO:0140273 biolink:BiologicalProcess repair of mitotic kinetochore microtubule attachment defect The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected. go.json correction of mitotic kinetochore microtubule attachment defects|repair of mitotic kinetochore microtubule attachment defects http://purl.obolibrary.org/obo/GO_0140273 GO:0140276 biolink:BiologicalProcess obsolete pericentric heterochromatin maintenance OBSOLETE. Any heterochromatin maintenance that is involved in chromatin silencing at or near a centromere. go.json heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region|heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats|heterochromatin maintenance involved in chromatin silencing at pericentric region True http://purl.obolibrary.org/obo/GO_0140276 GO:0140275 biolink:CellularComponent MIB complex A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1. go.json mitochondrial intermembrane space bridging complex|mitofilin complex http://purl.obolibrary.org/obo/GO_0140275 GO:0140278 biolink:BiologicalProcess mitotic division septum assembly The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. go.json http://purl.obolibrary.org/obo/GO_0140278 GO:0140270 biolink:BiologicalProcess gluconate import across plasma membrane The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140270 GO:0017040 biolink:MolecularActivity N-acylsphingosine amidohydrolase activity Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. EC:3.5.1.23|MetaCyc:CERAMIDASE-RXN|RHEA:20856|Reactome:R-HSA-1606583|Reactome:R-HSA-1606602|Reactome:R-HSA-428205|Reactome:R-HSA-428231 go.json acylsphingosine deacylase activity|glycosphingolipid ceramide deacylase http://purl.obolibrary.org/obo/GO_0017040 GO:0032679 biolink:BiologicalProcess regulation of TRAIL production Any process that modulates the frequency, rate, or extent of TRAIL production. go.json regulation of TRAIL biosynthetic process http://purl.obolibrary.org/obo/GO_0032679 GO:0032678 biolink:BiologicalProcess regulation of interleukin-9 production Any process that modulates the frequency, rate, or extent of interleukin-9 production. go.json regulation of IL-9 production|regulation of interleukin-9 biosynthetic process http://purl.obolibrary.org/obo/GO_0032678 GO:0032677 biolink:BiologicalProcess regulation of interleukin-8 production Any process that modulates the frequency, rate, or extent of interleukin-8 production. go.json regulation of IL-8 production|regulation of interleukin-8 biosynthetic process|regulation of interleukin-8 secretion http://purl.obolibrary.org/obo/GO_0032677 GO:0042002 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042002 GO:0042001 biolink:BiologicalProcess hermaphrodite somatic sex determination The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans. go.json http://purl.obolibrary.org/obo/GO_0042001 GO:0042004 biolink:BiologicalProcess feminization of hermaphrodite soma Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans. go.json http://purl.obolibrary.org/obo/GO_0042004 GO:0042003 biolink:BiologicalProcess masculinization of hermaphrodite soma Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans. go.json http://purl.obolibrary.org/obo/GO_0042003 GO:0042000 biolink:BiologicalProcess translocation of peptides or proteins into host The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json translocation of peptides or proteins into other organism during symbiotic interaction|translocation of peptides or proteins into other organism involved in symbiotic interaction|transport of peptides or proteins into host|transport of peptides or proteins into other organism during symbiotic interaction http://purl.obolibrary.org/obo/GO_0042000 GO:0042009 biolink:MolecularActivity interleukin-15 binding Binding to interleukin-15. go.json IL-15 binding http://purl.obolibrary.org/obo/GO_0042009 GO:0017039 biolink:MolecularActivity obsolete dipeptidyl-peptidase III activity OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides. go.json DPP III activity|dipeptidyl aminopeptidase III activity|dipeptidyl arylamidase III activity|dipeptidyl-peptidase III activity|enkephalinase B activity|red cell angiotensinase activity True http://purl.obolibrary.org/obo/GO_0017039 GO:0042006 biolink:BiologicalProcess masculinization of hermaphroditic germ-line The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans. go.json http://purl.obolibrary.org/obo/GO_0042006 GO:0017038 biolink:BiologicalProcess protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. go.json protein uptake http://purl.obolibrary.org/obo/GO_0017038 GO:0042005 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042005 GO:0042008 biolink:MolecularActivity interleukin-18 receptor activity Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-18 receptor activity|IL-18R http://purl.obolibrary.org/obo/GO_0042008 GO:0042007 biolink:MolecularActivity interleukin-18 binding Binding to interleukin-18. go.json IL-18 binding http://purl.obolibrary.org/obo/GO_0042007 GO:0017035 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017035 GO:0032676 biolink:BiologicalProcess regulation of interleukin-7 production Any process that modulates the frequency, rate, or extent of interleukin-7 production. go.json regulation of IL-7 production|regulation of interleukin-7 biosynthetic process|regulation of interleukin-7 secretion http://purl.obolibrary.org/obo/GO_0032676 GO:0017034 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017034 GO:0032675 biolink:BiologicalProcess regulation of interleukin-6 production Any process that modulates the frequency, rate, or extent of interleukin-6 production. go.json regulation of IL-6 production|regulation of interleukin-6 biosynthetic process http://purl.obolibrary.org/obo/GO_0032675 GO:0017037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017037 GO:0032674 biolink:BiologicalProcess regulation of interleukin-5 production Any process that modulates the frequency, rate, or extent of interleukin-5 production. go.json regulation of IL-5 production|regulation of interleukin-5 biosynthetic process|regulation of interleukin-5 secretion http://purl.obolibrary.org/obo/GO_0032674 GO:0032673 biolink:BiologicalProcess regulation of interleukin-4 production Any process that modulates the frequency, rate, or extent of interleukin-4 production. go.json regulation of IL-4 production|regulation of interleukin-4 biosynthetic process|regulation of interleukin-4 secretion http://purl.obolibrary.org/obo/GO_0032673 GO:0017036 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017036 GO:0032672 biolink:BiologicalProcess regulation of interleukin-3 production Any process that modulates the frequency, rate, or extent of interleukin-3 production. go.json regulation of IL-3 production|regulation of interleukin-3 biosynthetic process http://purl.obolibrary.org/obo/GO_0032672 GO:0017031 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017031 GO:0017030 biolink:MolecularActivity obsolete beta-galactosidase stabilization activity OBSOLETE. Stabilization of the structure of beta-galactosidase. go.json beta-galactosidase stabilization activity True http://purl.obolibrary.org/obo/GO_0017030 GO:0032671 biolink:BiologicalProcess regulation of interleukin-27 production Any process that modulates the frequency, rate, or extent of interleukin-27 production. go.json regulation of IL-27 production|regulation of interleukin-27 biosynthetic process|regulation of interleukin-27 formation|regulation of interleukin-27 synthesis http://purl.obolibrary.org/obo/GO_0032671 GO:0032670 biolink:BiologicalProcess regulation of interleukin-26 production Any process that modulates the frequency, rate, or extent of interleukin-26 production. go.json regulation of IL-26 production|regulation of interleukin-26 biosynthetic process http://purl.obolibrary.org/obo/GO_0032670 GO:0017033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017033 GO:0017032 biolink:MolecularActivity amino acid:potassium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in). go.json potassium:amino acid symporter activity http://purl.obolibrary.org/obo/GO_0017032 GO:0017051 biolink:MolecularActivity retinol dehydratase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol. go.json http://purl.obolibrary.org/obo/GO_0017051 GO:0017050 biolink:MolecularActivity D-erythro-sphingosine kinase activity Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. EC:2.7.1.91|MetaCyc:RXN3DJ-11417|RHEA:35847|Reactome:R-HSA-428273|Reactome:R-HSA-5218845|Reactome:R-HSA-9625814|Reactome:R-HSA-9695949 go.json sphingosine kinase activity http://purl.obolibrary.org/obo/GO_0017050 GO:0032669 biolink:BiologicalProcess regulation of interleukin-25 production Any process that modulates the frequency, rate, or extent of interleukin-25 production. go.json regulation of IL-25 production|regulation of interleukin-25 biosynthetic process|regulation of interleukin-25 secretion http://purl.obolibrary.org/obo/GO_0032669 GO:0032668 biolink:BiologicalProcess regulation of interleukin-24 production Any process that modulates the frequency, rate, or extent of interleukin-24 production. go.json regulation of IL-24 production|regulation of interleukin-24 biosynthetic process http://purl.obolibrary.org/obo/GO_0032668 GO:0032667 biolink:BiologicalProcess regulation of interleukin-23 production Any process that modulates the frequency, rate, or extent of interleukin-23 production. go.json regulation of IL-23 biosynthetic process|regulation of IL-23 production|regulation of interleukin-23 anabolism|regulation of interleukin-23 biosynthesis|regulation of interleukin-23 biosynthetic process|regulation of interleukin-23 formation|regulation of interleukin-23 synthesis http://purl.obolibrary.org/obo/GO_0032667 GO:0032666 biolink:BiologicalProcess regulation of interleukin-22 production Any process that modulates the frequency, rate, or extent of interleukin-22 production. go.json regulation of IL-22 production|regulation of interleukin-22 biosynthetic process http://purl.obolibrary.org/obo/GO_0032666 GO:0042013 biolink:MolecularActivity interleukin-19 binding Binding to interleukin-19. go.json IL-19 binding http://purl.obolibrary.org/obo/GO_0042013 GO:0042012 biolink:MolecularActivity interleukin-16 receptor activity Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-16 receptor activity|IL-16R http://purl.obolibrary.org/obo/GO_0042012 GO:0042015 biolink:MolecularActivity interleukin-20 binding Binding to interleukin-20. go.json IL-20 binding http://purl.obolibrary.org/obo/GO_0042015 GO:0042014 biolink:MolecularActivity interleukin-19 receptor activity Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-19 receptor activity|IL-19R http://purl.obolibrary.org/obo/GO_0042014 GO:0042011 biolink:MolecularActivity interleukin-16 binding Binding to interleukin-16. go.json IL-16 binding http://purl.obolibrary.org/obo/GO_0042011 GO:0042010 biolink:MolecularActivity interleukin-15 receptor activity Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-15 receptor activity|IL-15R http://purl.obolibrary.org/obo/GO_0042010 GO:0042017 biolink:MolecularActivity interleukin-22 binding Binding to interleukin-22. go.json IL-22 binding http://purl.obolibrary.org/obo/GO_0042017 GO:0042016 biolink:MolecularActivity interleukin-20 receptor activity Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-20 receptor activity|IL-20R http://purl.obolibrary.org/obo/GO_0042016 GO:0017049 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017049 GO:0042019 biolink:MolecularActivity interleukin-23 binding Binding to interleukin-23. go.json IL-23 binding http://purl.obolibrary.org/obo/GO_0042019 GO:0042018 biolink:MolecularActivity interleukin-22 receptor activity Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-22 receptor activity|IL-22R http://purl.obolibrary.org/obo/GO_0042018 GO:0032665 biolink:BiologicalProcess regulation of interleukin-21 production Any process that modulates the frequency, rate, or extent of interleukin-21 production. go.json regulation of IL-21 production|regulation of interleukin-21 biosynthetic process http://purl.obolibrary.org/obo/GO_0032665 GO:0017046 biolink:MolecularActivity peptide hormone binding Binding to a peptide with hormonal activity in animals. go.json polypeptide hormone binding http://purl.obolibrary.org/obo/GO_0017046 GO:0032664 biolink:BiologicalProcess regulation of interleukin-20 production Any process that modulates the frequency, rate, or extent of interleukin-20 production. go.json regulation of IL-20 production|regulation of interleukin-20 biosynthetic process http://purl.obolibrary.org/obo/GO_0032664 GO:0017045 biolink:MolecularActivity corticotropin-releasing hormone activity The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary. Wikipedia:Corticotropin-releasing_hormone go.json adrenocorticotropin-releasing hormone http://purl.obolibrary.org/obo/GO_0017045 GO:0032663 biolink:BiologicalProcess regulation of interleukin-2 production Any process that modulates the frequency, rate, or extent of interleukin-2 production. go.json regulation of IL-2 production|regulation of interleukin-2 biosynthetic process|regulation of interleukin-2 secretion http://purl.obolibrary.org/obo/GO_0032663 GO:0017048 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017048 GO:0032662 biolink:BiologicalProcess regulation of interleukin-19 production Any process that modulates the frequency, rate, or extent of interleukin-19 production. go.json regulation of IL-19 production|regulation of interleukin-19 biosynthetic process http://purl.obolibrary.org/obo/GO_0032662 GO:0017047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017047 GO:0017042 biolink:MolecularActivity glycosylceramidase activity Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. EC:3.2.1.62|MetaCyc:GALACTOSYLCERAMIDASE-RXN|MetaCyc:GLYCOSYLCERAMIDASE-RXN|MetaCyc:RXN-22900 go.json cerebrosidase activity|glycosyl ceramide glycosylhydrolase activity|glycosyl-N-acylsphingosine glycohydrolase activity http://purl.obolibrary.org/obo/GO_0017042 GO:0032661 biolink:BiologicalProcess regulation of interleukin-18 production Any process that modulates the frequency, rate, or extent of interleukin-18 production. go.json regulation of IL-18 production|regulation of interleukin-18 biosynthetic process|regulation of interleukin-18 secretion http://purl.obolibrary.org/obo/GO_0032661 GO:0032660 biolink:BiologicalProcess regulation of interleukin-17 production Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. go.json regulation of CTLA-8 production|regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion|regulation of IL-17 production|regulation of interleukin-17 biosynthetic process|regulation of interleukin-17 secretion http://purl.obolibrary.org/obo/GO_0032660 GO:0017041 biolink:MolecularActivity obsolete galactosylgalactosylglucosylceramidase activity OBSOLETE. Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. go.json D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity|ceramide trihexosidase activity|ceramidetrihexosidase activity|ceramidetrihexoside alpha-galactosidase activity|trihexosyl ceramide galactosidase activity|trihexosylceramide alpha-galactosidase activity True http://purl.obolibrary.org/obo/GO_0017041 GO:0017044 biolink:MolecularActivity melanocyte-stimulating hormone activity The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates. go.json alpha-melanocyte stimulating hormone activity|alpha-melanophore stimulating hormone activity|melanocyte stimulating hormone activity http://purl.obolibrary.org/obo/GO_0017044 GO:0017043 biolink:MolecularActivity obsolete adrenocorticotropin OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones. go.json adrenocorticotropin|corticotropin True http://purl.obolibrary.org/obo/GO_0017043 GO:0032659 biolink:BiologicalProcess regulation of interleukin-16 production Any process that modulates the frequency, rate, or extent of interleukin-16 production. go.json regulation of IL-16 production|regulation of interleukin-16 biosynthetic process http://purl.obolibrary.org/obo/GO_0032659 GO:0032658 biolink:BiologicalProcess regulation of interleukin-15 production Any process that modulates the frequency, rate, or extent of interleukin-15 production. go.json regulation of IL-15 production|regulation of interleukin-15 biosynthetic process http://purl.obolibrary.org/obo/GO_0032658 GO:0032657 biolink:BiologicalProcess obsolete regulation of interleukin-14 production OBSOLETE. Any process that modulates the frequency, rate, or extent of interleukin-14 production. go.json regulation of IL-14 production|regulation of interleukin-14 biosynthetic process True http://purl.obolibrary.org/obo/GO_0032657 GO:0032656 biolink:BiologicalProcess regulation of interleukin-13 production Any process that modulates the frequency, rate, or extent of interleukin-13 production. go.json regulation of IL-13 production|regulation of interleukin-13 biosynthetic process|regulation of interleukin-13 secretion http://purl.obolibrary.org/obo/GO_0032656 GO:0032655 biolink:BiologicalProcess regulation of interleukin-12 production Any process that modulates the frequency, rate, or extent of interleukin-12 production. go.json regulation of CLMF production|regulation of IL-12 production|regulation of NKSF production|regulation of interleukin-12 biosynthetic process|regulation of interleukin-12 secretion http://purl.obolibrary.org/obo/GO_0032655 GO:0042024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042024 GO:0042023 biolink:BiologicalProcess DNA endoreduplication Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes. go.json DNA endoreplication|DNA re-duplication http://purl.obolibrary.org/obo/GO_0042023 GO:0042026 biolink:BiologicalProcess protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. go.json heat shock protein activity http://purl.obolibrary.org/obo/GO_0042026 GO:0042025 biolink:CellularComponent host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0042025 GO:0042020 biolink:MolecularActivity interleukin-23 receptor activity Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json IL-23 receptor activity|IL-23R http://purl.obolibrary.org/obo/GO_0042020 GO:0042022 biolink:CellularComponent interleukin-12 receptor complex A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. go.json IL-12 receptor complex|IL12RB1-IL12RB2 complex http://purl.obolibrary.org/obo/GO_0042022 GO:0042021 biolink:MolecularActivity granulocyte macrophage colony-stimulating factor complex binding Binding to a granulocyte macrophage colony-stimulating factor complex. go.json GM-CSF complex binding|GMC-SF complex binding|granulocyte macrophage colony stimulating factor complex binding http://purl.obolibrary.org/obo/GO_0042021 GO:0017017 biolink:MolecularActivity MAP kinase tyrosine/serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. go.json dual-specificity MAP kinase phosphatase activity http://purl.obolibrary.org/obo/GO_0017017 GO:0042028 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042028 GO:0042027 biolink:MolecularActivity obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0). go.json cyclophilin-type peptidyl-prolyl cis-trans isomerase activity True http://purl.obolibrary.org/obo/GO_0042027 GO:0017016 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017016 GO:0017019 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017019 GO:0017018 biolink:MolecularActivity myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. Reactome:R-HSA-390593|Reactome:R-HSA-445699 go.json myosin phosphatase myosin binding|myosin phosphatase, intrinsic catalyst activity http://purl.obolibrary.org/obo/GO_0017018 GO:0042029 biolink:MolecularActivity obsolete fibrolase activity OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen. go.json Agkistrodon contortrix contortrix metalloproteinase activity|Agkistrodon contortrix contortrix venom metalloproteinase activity|fibrinolytic proteinase activity|fibrolase activity True http://purl.obolibrary.org/obo/GO_0042029 GO:0017013 biolink:BiologicalProcess protein flavinylation The addition of a flavin group to a protein amino acid. go.json protein amino acid flavinylation http://purl.obolibrary.org/obo/GO_0017013 gocheck_do_not_annotate GO:0032654 biolink:BiologicalProcess regulation of interleukin-11 production Any process that modulates the frequency, rate, or extent of interleukin-11 production. go.json regulation of IL-11 production|regulation of interleukin-11 biosynthetic process|regulation of interleukin-11 secretion http://purl.obolibrary.org/obo/GO_0032654 GO:0017012 biolink:BiologicalProcess protein-phytochromobilin linkage The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin. RESID:AA0133 go.json http://purl.obolibrary.org/obo/GO_0017012 gocheck_do_not_annotate GO:0032653 biolink:BiologicalProcess regulation of interleukin-10 production Any process that modulates the frequency, rate, or extent of interleukin-10 production. go.json regulation of IL-10 production|regulation of interleukin-10 biosynthetic process|regulation of interleukin-10 secretion http://purl.obolibrary.org/obo/GO_0032653 GO:0017015 biolink:BiologicalProcess regulation of transforming growth factor beta receptor signaling pathway Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. go.json regulation of TGF-beta receptor signaling pathway|regulation of TGFbeta receptor signaling pathway|regulation of transforming growth factor beta receptor signalling pathway http://purl.obolibrary.org/obo/GO_0017015 GO:0032652 biolink:BiologicalProcess regulation of interleukin-1 production Any process that modulates the frequency, rate, or extent of interleukin-1 production. go.json regulation of IL-1 production|regulation of interleukin-1 biosynthetic process|regulation of interleukin-1 secretion http://purl.obolibrary.org/obo/GO_0032652 GO:0017014 biolink:BiologicalProcess protein nitrosylation The covalent addition of a nitric oxide group to an amino acid within a protein. go.json protein amino acid nitrosylation http://purl.obolibrary.org/obo/GO_0017014 gocheck_do_not_annotate GO:0032651 biolink:BiologicalProcess regulation of interleukin-1 beta production Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. go.json regulation of IL-1 beta production|regulation of interleukin-1 beta biosynthetic process|regulation of interleukin-1 beta secretion http://purl.obolibrary.org/obo/GO_0032651 GO:0032650 biolink:BiologicalProcess regulation of interleukin-1 alpha production Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production. go.json regulation of IL-1 alpha production|regulation of interleukin-1 alpha biosynthetic process|regulation of interleukin-1 alpha secretion http://purl.obolibrary.org/obo/GO_0032650 GO:0017011 biolink:BiologicalProcess protein-phycoerythrobilin linkage The linkage of the chromophore phycoerythrobilin to phycoerythrins. RESID:AA0132 go.json http://purl.obolibrary.org/obo/GO_0017011 gocheck_do_not_annotate GO:0017010 biolink:BiologicalProcess protein-phycourobilin linkage The linkage of the chromophore phycourobilin to phycoerythrins. RESID:AA0260 go.json http://purl.obolibrary.org/obo/GO_0017010 gocheck_do_not_annotate GO:0032649 biolink:BiologicalProcess regulation of type II interferon production Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. go.json regulation of interferon-gamma biosynthetic process|regulation of interferon-gamma production|regulation of interferon-gamma secretion http://purl.obolibrary.org/obo/GO_0032649 GO:0032648 biolink:BiologicalProcess regulation of interferon-beta production Any process that modulates the frequency, rate, or extent of interferon-beta production. go.json regulation of IFN-beta production|regulation of interferon-beta biosynthetic process|regulation of interferon-beta secretion http://purl.obolibrary.org/obo/GO_0032648 GO:0032647 biolink:BiologicalProcess regulation of interferon-alpha production Any process that modulates the frequency, rate, or extent of interferon-alpha production. go.json regulation of interferon-alpha biosynthetic process|regulation of interferon-alpha secretion http://purl.obolibrary.org/obo/GO_0032647 GO:0032646 biolink:BiologicalProcess regulation of hepatocyte growth factor production Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production. go.json regulation of HGF production|regulation of hepatocyte growth factor biosynthetic process|regulation of scatter factor production http://purl.obolibrary.org/obo/GO_0032646 GO:0032645 biolink:BiologicalProcess regulation of granulocyte macrophage colony-stimulating factor production Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. go.json regulation of GM-CSF production|regulation of granulocyte macrophage colony stimulating factor production|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process http://purl.obolibrary.org/obo/GO_0032645 GO:0032644 biolink:BiologicalProcess regulation of fractalkine production Any process that modulates the frequency, rate, or extent of fractalkine production. go.json regulation of CX3CL1 biosynthesis|regulation of CX3CL1 production|regulation of fractalkine biosynthetic process http://purl.obolibrary.org/obo/GO_0032644 GO:0042035 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042035 GO:0042034 biolink:BiologicalProcess obsolete peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine OBSOLETE. The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester. go.json peptidyl-lysine esterification True http://purl.obolibrary.org/obo/GO_0042034 GO:0042037 biolink:BiologicalProcess peptidyl-histidine methylation, to form pros-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). RESID:AA0073 go.json peptidyl-histidine pros-methylation http://purl.obolibrary.org/obo/GO_0042037 gocheck_do_not_annotate GO:0042036 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042036 GO:0042031 biolink:MolecularActivity obsolete angiotensin-converting enzyme inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I. go.json ACE inhibitor|angiotensin-converting enzyme inhibitor activity|peptidyl dipeptidase A inhibitor True http://purl.obolibrary.org/obo/GO_0042031 GO:0042030 biolink:MolecularActivity ATPase inhibitor activity Binds to and stops, prevents or reduces an ATP hydrolysis activity. go.json adenosinetriphosphatase inhibitor http://purl.obolibrary.org/obo/GO_0042030 GO:0042033 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042033 GO:0042032 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042032 GO:0017028 biolink:MolecularActivity obsolete protein stabilization activity OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds. go.json protein stabilization activity True http://purl.obolibrary.org/obo/GO_0017028 GO:0042039 biolink:BiologicalProcess vanadium incorporation into metallo-sulfur cluster The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n). go.json vanadium incorporation into metallo-sulphur cluster http://purl.obolibrary.org/obo/GO_0042039 gocheck_do_not_annotate GO:0017027 biolink:MolecularActivity obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity OBSOLETE. (Was not defined before being made obsolete). go.json transmembrane receptor protein serine/threonine kinase receptor-associated protein activity True http://purl.obolibrary.org/obo/GO_0017027 GO:0042038 biolink:BiologicalProcess peptidyl-histidine methylation, to form tele-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine). RESID:AA0317 go.json peptidyl-histidine tele-methylation http://purl.obolibrary.org/obo/GO_0042038 gocheck_do_not_annotate GO:0017029 biolink:MolecularActivity obsolete lysosomal protein stabilization OBSOLETE. (Was not defined before being made obsolete). go.json lysosomal protein stabilization True http://purl.obolibrary.org/obo/GO_0017029 GO:0017024 biolink:MolecularActivity myosin I binding Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. go.json http://purl.obolibrary.org/obo/GO_0017024 GO:0032643 biolink:BiologicalProcess regulation of connective tissue growth factor production Any process that modulates the frequency, rate, or extent of connective tissue growth factor production. go.json regulation of CCN2 production|regulation of CTGF production|regulation of Fisp12 production|regulation of Hcs24 production|regulation of IGFBP8 production|regulation of connective tissue growth factor biosynthetic process|regulation of hypertrophic chondrocyte-specific gene product 24 production http://purl.obolibrary.org/obo/GO_0032643 GO:0032642 biolink:BiologicalProcess regulation of chemokine production Any process that modulates the frequency, rate, or extent of chemokine production. go.json regulation of chemokine biosynthetic process|regulation of chemokine secretion http://purl.obolibrary.org/obo/GO_0032642 GO:0017023 biolink:CellularComponent myosin phosphatase complex An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A). go.json http://purl.obolibrary.org/obo/GO_0017023 GO:0017026 biolink:MolecularActivity obsolete procollagen C-endopeptidase activity OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III. go.json BMP1|carboxyprocollagen peptidase activity|procollagen C-endopeptidase activity|procollagen C-proteinase activity|procollagen C-terminal peptidase activity|procollagen C-terminal proteinase activity|procollagen carboxy-terminal proteinase activity|procollagen carboxypeptidase activity|procollagen peptidase activity True http://purl.obolibrary.org/obo/GO_0017026 GO:0032641 biolink:BiologicalProcess lymphotoxin A production The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A. go.json LTA production|TNF-B production|TNF-beta production|lymphotoxin A biosynthetic process|lymphotoxin A formation|lymphotoxin A synthesis|lymphotoxin-alpha production|tumor necrosis factor-beta production http://purl.obolibrary.org/obo/GO_0032641 gocheck_do_not_annotate GO:0032640 biolink:BiologicalProcess tumor necrosis factor production The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. go.json TNF alpha biosynthesis|TNF biosynthesis|TNF biosynthetic process|TNF production|TNF-alpha biosynthesis|TNF-alpha biosynthetic process|TNF-alpha production|Tnfa production|cachectin production|tumor necrosis factor anabolism|tumor necrosis factor biosynthesis|tumor necrosis factor biosynthetic process|tumor necrosis factor formation|tumor necrosis factor secretion|tumor necrosis factor synthesis|tumor necrosis factor-alpha production http://purl.obolibrary.org/obo/GO_0032640 gocheck_do_not_annotate GO:0017025 biolink:MolecularActivity TBP-class protein binding Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). go.json TATA-binding protein binding|TBP binding|TBP-related factor (TRF) protein binding http://purl.obolibrary.org/obo/GO_0017025 GO:0017020 biolink:MolecularActivity myosin phosphatase regulator activity Binds to and modulates of the activity of myosin phosphatase. go.json myosin phosphatase, intrinsic regulator activity http://purl.obolibrary.org/obo/GO_0017020 GO:0017022 biolink:MolecularActivity myosin binding Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. go.json myosin phosphatase myosin binding http://purl.obolibrary.org/obo/GO_0017022 GO:0017021 biolink:MolecularActivity obsolete myosin phosphatase myosin binding OBSOLETE. (Was not defined before being made obsolete). go.json myosin phosphatase myosin binding True http://purl.obolibrary.org/obo/GO_0017021 GO:0032639 biolink:BiologicalProcess TRAIL production The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json TRAIL biosynthetic process http://purl.obolibrary.org/obo/GO_0032639 gocheck_do_not_annotate GO:0042040 biolink:BiologicalProcess metal incorporation into metallo-molybdopterin complex The incorporation of a metal into a metallo-molybdopterin complex. go.json http://purl.obolibrary.org/obo/GO_0042040 gocheck_do_not_annotate GO:0032638 biolink:BiologicalProcess interleukin-9 production The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-9 production|interleukin-9 biosynthetic process|interleukin-9 secretion http://purl.obolibrary.org/obo/GO_0032638 gocheck_do_not_annotate GO:0032637 biolink:BiologicalProcess interleukin-8 production The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-8 production|interleukin-8 biosynthetic process|interleukin-8 secretion http://purl.obolibrary.org/obo/GO_0032637 gocheck_do_not_annotate GO:0032636 biolink:BiologicalProcess interleukin-7 production The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-7 production|interleukin-7 biosynthetic process|interleukin-7 secretion http://purl.obolibrary.org/obo/GO_0032636 gocheck_do_not_annotate GO:0032635 biolink:BiologicalProcess interleukin-6 production The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-6 production|interleukin-6 biosynthetic process|interleukin-6 secretion http://purl.obolibrary.org/obo/GO_0032635 gocheck_do_not_annotate GO:0032634 biolink:BiologicalProcess interleukin-5 production The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-5 production|interleukin-5 biosynthetic process|interleukin-5 secretion http://purl.obolibrary.org/obo/GO_0032634 gocheck_do_not_annotate GO:0032633 biolink:BiologicalProcess interleukin-4 production The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-4 production|interleukin-4 biosynthetic process|interleukin-4 secretion http://purl.obolibrary.org/obo/GO_0032633 gocheck_do_not_annotate GO:0042046 biolink:BiologicalProcess W-molybdopterin cofactor metabolic process The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. go.json Moco metabolic process|Moco metabolism|W-molybdopterin cofactor metabolism http://purl.obolibrary.org/obo/GO_0042046 GO:0042045 biolink:BiologicalProcess epithelial fluid transport The directed movement of fluid across epithelia. go.json http://purl.obolibrary.org/obo/GO_0042045 GO:0042048 biolink:BiologicalProcess olfactory behavior The behavior of an organism in response to an odor. go.json behavioral response to scent|behavioral response to smell|behavioural response to odour|behavioural response to scent|behavioural response to smell|olfactory behaviour http://purl.obolibrary.org/obo/GO_0042048 GO:0042047 biolink:BiologicalProcess W-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. go.json Moco biosynthesis|Moco biosynthetic process|W-molybdopterin cofactor anabolism|W-molybdopterin cofactor biosynthesis|W-molybdopterin cofactor formation|W-molybdopterin cofactor synthesis http://purl.obolibrary.org/obo/GO_0042047 GO:0042042 biolink:BiologicalProcess tungsten incorporation into tungsten-molybdopterin complex The incorporation of tungsten into a tungsten-molybdopterin complex. go.json http://purl.obolibrary.org/obo/GO_0042042 gocheck_do_not_annotate GO:0042041 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042041 GO:0042044 biolink:BiologicalProcess fluid transport The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0042044 goslim_pir GO:0042043 biolink:MolecularActivity neurexin family protein binding Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. go.json neuroligin http://purl.obolibrary.org/obo/GO_0042043 GO:0042049 biolink:BiologicalProcess intracellular acyl-CoA homeostasis A homeostatic process involved in the maintenance of a steady state level of acyl-CoA within a cell. go.json cell acyl-CoA homeostasis|cellular acyl-CoA homeostasis http://purl.obolibrary.org/obo/GO_0042049 GO:0032632 biolink:BiologicalProcess interleukin-3 production The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-3 production|interleukin-3 biosynthetic process|interleukin-3 secretion http://purl.obolibrary.org/obo/GO_0032632 gocheck_do_not_annotate GO:0032631 biolink:BiologicalProcess interleukin-27 production The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-27 production|interleukin-27 biosynthetic process|interleukin-27 formation|interleukin-27 secretion|interleukin-27 synthesis http://purl.obolibrary.org/obo/GO_0032631 gocheck_do_not_annotate GO:0032630 biolink:BiologicalProcess interleukin-26 production The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json AK155 secretion|IL-26 production|interleukin-26 anabolism|interleukin-26 biosynthesis|interleukin-26 biosynthetic process|interleukin-26 formation|interleukin-26 secretion|interleukin-26 synthesis http://purl.obolibrary.org/obo/GO_0032630 gocheck_do_not_annotate GO:0032629 biolink:BiologicalProcess interleukin-25 production The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-25 production|IL-25 secretion|IL17E secretion|interleukin-25 anabolism|interleukin-25 biosynthesis|interleukin-25 biosynthetic process|interleukin-25 formation|interleukin-25 secretion|interleukin-25 synthesis http://purl.obolibrary.org/obo/GO_0032629 gocheck_do_not_annotate GO:0032628 biolink:BiologicalProcess interleukin-24 production The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-24 production|MDA7 production|ST16 production|interleukin-24 biosynthetic process|interleukin-24 secretion http://purl.obolibrary.org/obo/GO_0032628 gocheck_do_not_annotate GO:0032627 biolink:BiologicalProcess interleukin-23 production The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-23 production|interleukin-23 biosynthetic process|interleukin-23 secretion http://purl.obolibrary.org/obo/GO_0032627 gocheck_do_not_annotate GO:0042051 biolink:BiologicalProcess compound eye photoreceptor development The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure. go.json adult eye photoreceptor development http://purl.obolibrary.org/obo/GO_0042051 GO:0032626 biolink:BiologicalProcess interleukin-22 production The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-22 production|IL22 production|ILTIF production|ZCYTO18 production|interleukin-22 biosynthetic process|interleukin-22 secretion http://purl.obolibrary.org/obo/GO_0032626 gocheck_do_not_annotate GO:0042050 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042050 GO:0032625 biolink:BiologicalProcess interleukin-21 production The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-21 production|interleukin-21 biosynthetic process|interleukin-21 secretion http://purl.obolibrary.org/obo/GO_0032625 gocheck_do_not_annotate GO:0032624 biolink:BiologicalProcess interleukin-20 production The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-20 production|ZCYTO10 production|interleukin-20 biosynthetic process|interleukin-20 secretion http://purl.obolibrary.org/obo/GO_0032624 gocheck_do_not_annotate GO:0032623 biolink:BiologicalProcess interleukin-2 production The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-2 production|interleukin-2 biosynthetic process|interleukin-2 secretion http://purl.obolibrary.org/obo/GO_0032623 gocheck_do_not_annotate GO:0032622 biolink:BiologicalProcess interleukin-19 production The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-19 production|IL-19 secretion|ZMDA1 secretion|interleukin-19 biosynthetic process|interleukin-19 secretion http://purl.obolibrary.org/obo/GO_0032622 gocheck_do_not_annotate GO:0042057 biolink:MolecularActivity obsolete transforming growth factor beta receptor anchoring activity OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location. go.json TGF-beta receptor anchoring activity|TGFbeta receptor anchoring activity|transforming growth factor beta receptor anchor activity|transforming growth factor beta receptor anchoring activity True http://purl.obolibrary.org/obo/GO_0042057 GO:0042056 biolink:MolecularActivity chemoattractant activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. go.json attractant http://purl.obolibrary.org/obo/GO_0042056 goslim_chembl|goslim_pir GO:0042059 biolink:BiologicalProcess negative regulation of epidermal growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. go.json down regulation of epidermal growth factor receptor signaling pathway|down-regulation of epidermal growth factor receptor signaling pathway|downregulation of epidermal growth factor receptor signaling pathway|inhibition of epidermal growth factor receptor signaling pathway|negative regulation of EGF receptor signaling pathway|negative regulation of EGF receptor signalling pathway|negative regulation of EGFR signaling pathway http://purl.obolibrary.org/obo/GO_0042059 GO:0042058 biolink:BiologicalProcess regulation of epidermal growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. go.json regulation of EGF receptor signaling pathway|regulation of EGF receptor signalling pathway|regulation of EGFR signaling pathway http://purl.obolibrary.org/obo/GO_0042058 GO:0042053 biolink:BiologicalProcess regulation of dopamine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. go.json regulation of dopamine metabolism http://purl.obolibrary.org/obo/GO_0042053 GO:0042052 biolink:BiologicalProcess rhabdomere development The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. go.json rhabdomere organization http://purl.obolibrary.org/obo/GO_0042052 GO:0042055 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042055 GO:0042054 biolink:MolecularActivity histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. Reactome:R-HSA-5205861|Reactome:R-HSA-5216234|Reactome:R-HSA-9822583 go.json histone N-methyltransferase activity|histone methylase activity http://purl.obolibrary.org/obo/GO_0042054 GO:0017009 biolink:BiologicalProcess protein-phycocyanobilin linkage The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin. RESID:AA0131 go.json http://purl.obolibrary.org/obo/GO_0017009 gocheck_do_not_annotate GO:0017006 biolink:BiologicalProcess protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. go.json http://purl.obolibrary.org/obo/GO_0017006 gocheck_do_not_annotate GO:0017005 biolink:MolecularActivity 3'-tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. go.json http://purl.obolibrary.org/obo/GO_0017005 GO:0017008 biolink:BiologicalProcess protein-phycobiliviolin linkage The linkage of the chromophore phycobiliviolin to phycoerythrocyanin. RESID:AA0258 go.json http://purl.obolibrary.org/obo/GO_0017008 gocheck_do_not_annotate GO:0017007 biolink:BiologicalProcess protein-bilin linkage The covalent linkage of bilin and a protein. go.json http://purl.obolibrary.org/obo/GO_0017007 gocheck_do_not_annotate GO:0032621 biolink:BiologicalProcess interleukin-18 production The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IGIF production|IL-18 production|IL1F4 production|interleukin-18 biosynthetic process|interleukin-18 secretion http://purl.obolibrary.org/obo/GO_0032621 gocheck_do_not_annotate GO:0017002 biolink:MolecularActivity activin receptor activity Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. go.json activin-activated receptor activity http://purl.obolibrary.org/obo/GO_0017002 GO:0032620 biolink:BiologicalProcess interleukin-17 production The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CTLA-8 production|Cytotoxic T-lymphocyte-associated antigen 8 production|IL-17 production|interleukin-17 biosynthetic process|interleukin-17 secretion http://purl.obolibrary.org/obo/GO_0032620 gocheck_do_not_annotate GO:0017001 biolink:BiologicalProcess antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. go.json antibiotic breakdown|antibiotic catabolism|antibiotic degradation http://purl.obolibrary.org/obo/GO_0017001 GO:0017004 biolink:BiologicalProcess cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. go.json cytochrome biogenesis http://purl.obolibrary.org/obo/GO_0017004 goslim_metagenomics GO:0017003 biolink:BiologicalProcess protein-heme linkage The covalent linkage of heme and a protein. go.json protein-haem linkage http://purl.obolibrary.org/obo/GO_0017003 gocheck_do_not_annotate GO:0017000 biolink:BiologicalProcess antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. go.json antibiotic anabolism|antibiotic biosynthesis|antibiotic formation|antibiotic synthesis http://purl.obolibrary.org/obo/GO_0017000 goslim_metagenomics GO:0032618 biolink:BiologicalProcess interleukin-15 production The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-15 production|interleukin-15 biosynthetic process|interleukin-15 secretion http://purl.obolibrary.org/obo/GO_0032618 gocheck_do_not_annotate GO:0042060 biolink:BiologicalProcess wound healing The series of events that restore integrity to a damaged tissue, following an injury. Wikipedia:Wound_healing go.json http://purl.obolibrary.org/obo/GO_0042060 goslim_generic GO:0032617 biolink:BiologicalProcess obsolete interleukin-14 production OBSOLETE. The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-14 production|interleukin-14 biosynthetic process|interleukin-14 secretion True http://purl.obolibrary.org/obo/GO_0032617 GO:0032616 biolink:BiologicalProcess interleukin-13 production The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-13 production|interleukin-13 biosynthetic process|interleukin-13 secretion http://purl.obolibrary.org/obo/GO_0032616 gocheck_do_not_annotate GO:0042062 biolink:BiologicalProcess long-term strengthening of neuromuscular junction Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse. go.json http://purl.obolibrary.org/obo/GO_0042062 GO:0032615 biolink:BiologicalProcess interleukin-12 production The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CLMF production|IL-12 production|NKSF production|interleukin-12 biosynthetic process|interleukin-12 secretion http://purl.obolibrary.org/obo/GO_0032615 gocheck_do_not_annotate GO:0042061 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042061 GO:0032614 biolink:BiologicalProcess interleukin-11 production The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-11 production|interleukin-11 biosynthetic process|interleukin-11 secretion http://purl.obolibrary.org/obo/GO_0032614 gocheck_do_not_annotate GO:0032613 biolink:BiologicalProcess interleukin-10 production The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-10 production|interleukin-10 biosynthetic process|interleukin-10 secretion http://purl.obolibrary.org/obo/GO_0032613 gocheck_do_not_annotate GO:0032612 biolink:BiologicalProcess interleukin-1 production The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-1 production|interleukin-1 biosynthetic process|interleukin-1 secretion http://purl.obolibrary.org/obo/GO_0032612 gocheck_do_not_annotate GO:0032611 biolink:BiologicalProcess interleukin-1 beta production The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-1 beta production|interleukin-1 beta biosynthetic process|interleukin-1 beta secretion http://purl.obolibrary.org/obo/GO_0032611 gocheck_do_not_annotate GO:0042068 biolink:BiologicalProcess regulation of pteridine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine. go.json regulation of pteridine metabolism http://purl.obolibrary.org/obo/GO_0042068 GO:0042067 biolink:BiologicalProcess establishment of ommatidial planar polarity The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part. go.json establishment of ommatidial polarity http://purl.obolibrary.org/obo/GO_0042067 GO:0042069 biolink:BiologicalProcess regulation of catecholamine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. go.json regulation of catecholamine metabolism http://purl.obolibrary.org/obo/GO_0042069 GO:0042064 biolink:MolecularActivity obsolete cell adhesion receptor regulator activity OBSOLETE. (Was not defined before being made obsolete). go.json cell adhesion receptor regulator activity True http://purl.obolibrary.org/obo/GO_0042064 GO:0042063 biolink:BiologicalProcess gliogenesis The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. go.json glial cell generation http://purl.obolibrary.org/obo/GO_0042063 GO:0042066 biolink:BiologicalProcess perineurial glial growth Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons. go.json http://purl.obolibrary.org/obo/GO_0042066 GO:0032619 biolink:BiologicalProcess interleukin-16 production The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-16 production|LCF production|interleukin-16 biosynthetic process|interleukin-16 secretion|pro-interleukin-16 production http://purl.obolibrary.org/obo/GO_0032619 gocheck_do_not_annotate GO:0042065 biolink:BiologicalProcess glial cell growth Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. go.json http://purl.obolibrary.org/obo/GO_0042065 GO:0032610 biolink:BiologicalProcess interleukin-1 alpha production The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IL-1 alpha production|interleukin-1 alpha biosynthetic process|interleukin-1 alpha secretion http://purl.obolibrary.org/obo/GO_0032610 gocheck_do_not_annotate GO:0032607 biolink:BiologicalProcess interferon-alpha production The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-alpha production|IFNA production|interferon-alpha biosynthetic process|interferon-alpha secretion http://purl.obolibrary.org/obo/GO_0032607 gocheck_do_not_annotate GO:0042071 biolink:MolecularActivity leucokinin receptor activity Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0042071 GO:0042070 biolink:BiologicalProcess maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster. go.json maintenance of oocyte nucleus localization during oocyte axis determination|maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification|maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination|maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification|maintenance of oocyte nucleus position during oocyte axis determination|oocyte axis determination, maintenance of oocyte nucleus localization|oocyte axis determination, maintenance of oocyte nucleus position|oocyte axis determination, oocyte nucleus anchoring|oocyte nucleus anchoring during oocyte axis determination http://purl.obolibrary.org/obo/GO_0042070 GO:0032606 biolink:BiologicalProcess type I interferon production The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json interferon type I production|type I IFN production|type I interferon biosynthetic process|type I interferon secretion http://purl.obolibrary.org/obo/GO_0032606 gocheck_do_not_annotate GO:0042073 biolink:BiologicalProcess intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. Wikipedia:Intraflagellar_transport go.json IFT|intraflagellar transport|intraflagellar transport involved in cilium organization|intraflagellar transport involved in microtubule-based flagellum organisation http://purl.obolibrary.org/obo/GO_0042073 GO:0032605 biolink:BiologicalProcess hepatocyte growth factor production The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json HGF production|hepatocyte growth factor biosynthetic process|scatter factor production http://purl.obolibrary.org/obo/GO_0032605 gocheck_do_not_annotate GO:0032604 biolink:BiologicalProcess granulocyte macrophage colony-stimulating factor production The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json GM-CSF production|granulocyte macrophage colony stimulating factor production|granulocyte macrophage colony-stimulating factor biosynthetic process http://purl.obolibrary.org/obo/GO_0032604 gocheck_do_not_annotate GO:0042072 biolink:MolecularActivity obsolete cell adhesion receptor inhibitor activity OBSOLETE. (Was not defined before being made obsolete). go.json cell adhesion receptor inhibitor activity True http://purl.obolibrary.org/obo/GO_0042072 GO:0032603 biolink:BiologicalProcess fractalkine production The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json ABCD-3 production|CX3CL1 production|fractalkine biosynthetic process|fractalkine metabolic process|neurotactin production http://purl.obolibrary.org/obo/GO_0032603 gocheck_do_not_annotate GO:0032602 biolink:BiologicalProcess chemokine production The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. go.json chemokine anabolism|chemokine biosynthesis|chemokine biosynthetic process|chemokine formation|chemokine metabolic process|chemokine secretion|chemokine synthesis http://purl.obolibrary.org/obo/GO_0032602 gocheck_do_not_annotate GO:0032601 biolink:BiologicalProcess connective tissue growth factor production The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCN2 production|CTGF production|Fisp12 production|Hcs24 production|IGFBP8 production|hypertrophic chondrocyte-specific gene product 24 production http://purl.obolibrary.org/obo/GO_0032601 gocheck_do_not_annotate GO:0032600 biolink:BiologicalProcess chemokine receptor transport out of membrane raft The directed movement of a chemokine receptor out of a membrane raft. go.json chemokine receptor translocation out of membrane raft|chemokine receptor transport out of lipid raft http://purl.obolibrary.org/obo/GO_0032600 GO:0042079 biolink:BiologicalProcess obsolete GPI/GSI anchor metabolic process OBSOLETE. (Was not defined before being made obsolete). go.json GPI/GSI anchor metabolic process True http://purl.obolibrary.org/obo/GO_0042079 GO:0042078 biolink:BiologicalProcess germ-line stem cell division The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. go.json germ-line stem cell renewal http://purl.obolibrary.org/obo/GO_0042078 GO:0042075 biolink:BiologicalProcess nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. RESID:AA0310 go.json nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide http://purl.obolibrary.org/obo/GO_0042075 gocheck_do_not_annotate GO:0042074 biolink:BiologicalProcess cell migration involved in gastrulation The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). go.json http://purl.obolibrary.org/obo/GO_0042074 GO:0032609 biolink:BiologicalProcess type II interferon production The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. go.json IFNG production|interferon-gamma biosynthetic process|interferon-gamma production|interferon-gamma secretion|type II IFN production http://purl.obolibrary.org/obo/GO_0032609 gocheck_do_not_annotate GO:0042077 biolink:BiologicalProcess protein phosphate-linked glycosylation via serine The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. go.json protein amino acid phosphate-linked glycosylation via serine http://purl.obolibrary.org/obo/GO_0042077 gocheck_do_not_annotate GO:0032608 biolink:BiologicalProcess interferon-beta production The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json IFN-beta production|IFNB production|interferon-beta biosynthetic process|interferon-beta secretion http://purl.obolibrary.org/obo/GO_0032608 gocheck_do_not_annotate GO:0042076 biolink:BiologicalProcess protein phosphate-linked glycosylation The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. go.json phosphoglycosylation|protein amino acid phosphate-linked glycosylation http://purl.obolibrary.org/obo/GO_0042076 GO:0140507 biolink:BiologicalProcess granzyme-mediated programmed cell death signaling pathway The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells. go.json granzyme-mediated cell death signaling pathway http://purl.obolibrary.org/obo/GO_0140507 GO:0140509 biolink:BiologicalProcess epithelium-like organization The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins. go.json http://purl.obolibrary.org/obo/GO_0140509 GO:0140500 biolink:BiologicalProcess regulation of reticulophagy Any process that modulates the frequency, rate or extent of reticulophagy. go.json regulation of ER autophagy|regulation of ER degradation|regulation of ER-phagy|regulation of autophagy of the ER|regulation of autophagy of the endoplasmic reticulum|regulation of endoplasmic reticulum autophagy|regulation of endoplasmic reticulum degradation http://purl.obolibrary.org/obo/GO_0140500 GO:0140502 biolink:BiologicalProcess effector-mediated suppression of host salicylic acid-mediated innate immune signaling A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signaling. go.json effector-mediated disruption of host salicylic acid-mediated innate immune signalling|effector-mediated suppression of host salicylic acid-mediated innate immune signalling http://purl.obolibrary.org/obo/GO_0140502 GO:0140501 biolink:BiologicalProcess positive regulation of reticulophagy Any process that increases the frequency, rate or extent of reticulophagy. go.json positive regulation of ER autophagy|positive regulation of ER degradation|positive regulation of ER-phagy|positive regulation of autophagy of the ER|positive regulation of autophagy of the endoplasmic reticulum|positive regulation of endoplasmic reticulum autophagy|positive regulation of endoplasmic reticulum degradation http://purl.obolibrary.org/obo/GO_0140501 GO:0140504 biolink:BiologicalProcess microlipophagy Degradation of a lipid droplet by microautophagy. go.json lipid droplet autophagy http://purl.obolibrary.org/obo/GO_0140504 GO:0140506 biolink:MolecularActivity endoplasmic reticulum-autophagosome adaptor activity The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy. go.json ER- autophagosome anchor|autophagosome-ER anchor|autophagosome-endoplasmic reticulum anchor http://purl.obolibrary.org/obo/GO_0140506 GO:0140505 biolink:BiologicalProcess regulation of microlipophagy Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion. go.json http://purl.obolibrary.org/obo/GO_0140505 GO:0140529 biolink:BiologicalProcess CMG complex assembly The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes. go.json http://purl.obolibrary.org/obo/GO_0140529 GO:0140522 biolink:MolecularActivity fusogenic activity The activity of joining two lipid bilayers to form a single membrane. go.json http://purl.obolibrary.org/obo/GO_0140522 GO:0140523 biolink:MolecularActivity GTPase-dependent fusogenic activity A GTPase activity that mediates the joining two lipid bilayers to form a single membrane. go.json membrane fusion GTPase activity http://purl.obolibrary.org/obo/GO_0140523 GO:0140526 biolink:BiologicalProcess double membrane vesicle viral factory assembly A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle. go.json http://purl.obolibrary.org/obo/GO_0140526 GO:0140525 biolink:CellularComponent antipodal site The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication. go.json antipodal zone http://purl.obolibrary.org/obo/GO_0140525 GO:0140528 biolink:BiologicalProcess bilobe structure assembly The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). go.json bilobe structure biogenesis|bilobe structure formation|kinetoplastid flagellar hook complex assembly http://purl.obolibrary.org/obo/GO_0140528 GO:0140527 biolink:BiologicalProcess reciprocal homologous recombination A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules. go.json http://purl.obolibrary.org/obo/GO_0140527 GO:0017097 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017097 GO:0017096 biolink:MolecularActivity acetylserotonin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. EC:2.1.1.4|MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN|RHEA:15573 go.json N-acetylserotonin O-methyltransferase activity|S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity|acetylserotonin methyltransferase activity|hydroxyindole O-methyltransferase activity|hydroxyindole methyltransferase activity http://purl.obolibrary.org/obo/GO_0017096 GO:0017099 biolink:MolecularActivity very-long-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. EC:1.3.8.9|RHEA:19181|Reactome:R-HSA-548831 go.json very long-chain-acyl-CoA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0017099 GO:0017098 biolink:MolecularActivity sulfonylurea receptor binding Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel. go.json sulfonylurea receptor ligand|sulphonylurea receptor binding http://purl.obolibrary.org/obo/GO_0017098 GO:0140511 biolink:CellularComponent mitotic nuclear bridge stalk Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes. go.json http://purl.obolibrary.org/obo/GO_0140511 GO:0140510 biolink:CellularComponent mitotic nuclear bridge A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei. go.json nuclear bridge http://purl.obolibrary.org/obo/GO_0140510 GO:0140513 biolink:CellularComponent nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. go.json nuclear complex http://purl.obolibrary.org/obo/GO_0140513 gocheck_do_not_annotate GO:0140512 biolink:CellularComponent mitotic nuclear bridge midzone The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei. go.json http://purl.obolibrary.org/obo/GO_0140512 GO:0140515 biolink:BiologicalProcess mitotic nuclear bridge organization A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis. go.json http://purl.obolibrary.org/obo/GO_0140515 GO:0140517 biolink:MolecularActivity protein-RNA adaptor activity The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way. go.json http://purl.obolibrary.org/obo/GO_0140517 GO:0140516 biolink:BiologicalProcess mitotic nuclear pore complex disassembly The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis. go.json nuclear pore complex disassembly during mitosis http://purl.obolibrary.org/obo/GO_0140516 GO:0017082 biolink:MolecularActivity obsolete mineralocorticoid receptor activity OBSOLETE. Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by binding to a specific DNA sequence in order to modulate transcription by RNA polymerase II. go.json aldosterone receptor True http://purl.obolibrary.org/obo/GO_0017082 GO:0017081 biolink:MolecularActivity chloride channel regulator activity Binds to and modulates the activity of a chloride channel. Reactome:R-HSA-383190 go.json http://purl.obolibrary.org/obo/GO_0017081 GO:0017084 biolink:MolecularActivity delta1-pyrroline-5-carboxylate synthetase activity Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate. RHEA:33207|Reactome:R-HSA-508040 go.json D1-pyrroline-5-carboxylate synthetase activity http://purl.obolibrary.org/obo/GO_0017084 GO:0017083 biolink:MolecularActivity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. EC:2.4.1.152|MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN|RHEA:14257 go.json GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity|GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity|GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity|Lewis-negative alpha-3-fucosyltransferase activity|galactoside 3-L-fucosyltransferase activity|galactoside 3-fucosyltransferase activity|guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity|guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity|plasma alpha-3-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0017083 GO:0017080 biolink:MolecularActivity sodium channel regulator activity Binds to and modulates the activity of a sodium channel. go.json http://purl.obolibrary.org/obo/GO_0017080 GO:0017079 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017079 GO:0017078 biolink:MolecularActivity obsolete Hsc70 protein regulator activity OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70. go.json Hsc70 interacting protein|Hsc70 protein regulator activity True http://purl.obolibrary.org/obo/GO_0017078 GO:0017075 biolink:MolecularActivity syntaxin-1 binding Binding to a syntaxin-1 SNAP receptor. go.json http://purl.obolibrary.org/obo/GO_0017075 GO:0017074 biolink:MolecularActivity obsolete procollagen N-endopeptidase activity OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln. go.json aminoprocollagen peptidase activity|aminoterminal procollagen peptidase activity|procollagen N-endopeptidase activity|procollagen N-proteinase activity|procollagen N-terminal peptidase activity|procollagen N-terminal proteinase activity|procollagen aminopeptidase activity|procollagen aminoterminal protease activity|type I/II procollagen N-proteinase activity|type III procollagen True http://purl.obolibrary.org/obo/GO_0017074 GO:0017077 biolink:MolecularActivity oxidative phosphorylation uncoupler activity Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. go.json mitochondrial uncoupling protein activity|uncoupling protein activity http://purl.obolibrary.org/obo/GO_0017077 GO:0017076 biolink:MolecularActivity purine nucleotide binding Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. go.json http://purl.obolibrary.org/obo/GO_0017076 GO:0017093 biolink:MolecularActivity obsolete sterol regulatory element-binding protein protease activity OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. go.json SREBP protease activity|sterol regulatory element-binding protein protease activity True http://purl.obolibrary.org/obo/GO_0017093 GO:0017092 biolink:MolecularActivity obsolete sterol regulatory element-binding protein site 2 protease activity OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus. go.json SREBP site 2 protease activity|sterol regulatory element-binding protein site 2 protease activity True http://purl.obolibrary.org/obo/GO_0017092 GO:0017095 biolink:MolecularActivity heparan sulfate 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. Reactome:R-HSA-2076419 go.json heparan sulphate 6-O-sulphotransferase activity|heparin 6-O-sulfotransferase activity http://purl.obolibrary.org/obo/GO_0017095 GO:0017094 biolink:MolecularActivity obsolete sterol regulatory element-binding protein site 1 protease activity OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves. go.json SREBP site 1 protease activity|sterol regulatory element-binding protein site 1 protease activity True http://purl.obolibrary.org/obo/GO_0017094 GO:0017091 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017091 GO:0017090 biolink:CellularComponent meprin A complex A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues. go.json PABA peptide hydrolase complex http://purl.obolibrary.org/obo/GO_0017090 GO:0017089 biolink:MolecularActivity glycolipid transfer activity Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. Reactome:R-HSA-5340320|Reactome:R-HSA-9697077 go.json glycolipid carrier activity|glycolipid transporter activity|intermembrane glycolipid transfer activity|intermembrane glycolipid transporter activity http://purl.obolibrary.org/obo/GO_0017089 GO:0017086 biolink:CellularComponent 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate. go.json BCADH|branched-chain alpha-ketoacid dehydrogenase complex http://purl.obolibrary.org/obo/GO_0017086 GO:0017085 biolink:BiologicalProcess response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. go.json insecticide resistance|insecticide susceptibility/resistance http://purl.obolibrary.org/obo/GO_0017085 GO:0017088 biolink:MolecularActivity obsolete X-Pro dipeptidyl-peptidase activity OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile. go.json PepX|X-Pro dipeptidyl-peptidase activity|X-prolyl dipeptidyl aminopeptidase activity|X-prolyl dipeptidyl peptidase activity|Xaa-Pro dipeptidyl-peptidase activity True http://purl.obolibrary.org/obo/GO_0017088 GO:0017087 biolink:CellularComponent mitochondrial processing peptidase complex A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0017087 GO:0017060 biolink:MolecularActivity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. EC:2.4.1.65|MetaCyc:2.4.1.65-RXN|RHEA:23628|Reactome:R-HSA-5693925|Reactome:R-HSA-9603986 go.json (Le(a))-dependent (alpha-3/4)-fucosyltransferase activity|(Lea)-dependent (alpha-3/4)-fucosyltransferase activity|3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|FucT-II activity|GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity|GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity|Lewis FT activity|Lewis alpha-(1,3/4)-fucosyltransferase activity|Lewis alpha-(1->3/4)-fucosyltransferase activity|Lewis blood group alpha-(1,3/4)-fucosyltransferase activity|Lewis blood group alpha-(1->3/4)-fucosyltransferase activity|Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity|Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity|alpha(1,4)-L-fucosyltransferase activity|alpha-(1,3/1,4) fucosyltransferase III activity|alpha-(1,4)-L-fucosyltransferase activity|alpha-(1->4)-L-fucosyltransferase activity|alpha-4-L-fucosyltransferase activity|beta-acetylglucosaminylsaccharide fucosyltransferase activity|blood group Lewis alpha-4-fucosyltransferase activity|blood-group substance Le(a)-dependent fucosyltransferase activity|blood-group substance Lea-dependent fucosyltransferase|fuca(1,3)-glycosidic linkage formation|galactoside 3(4)-L-fucosyltransferase activity|guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity|guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity|guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0017060 GO:0017062 biolink:BiologicalProcess respiratory chain complex III assembly The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents. go.json coenzyme Q and cytochrome c reductase complex assembly|coenzyme Q and cytochrome c reductase complex biogenesis|complex III assembly|complex III biogenesis|cytochrome bc(1) complex assembly|cytochrome bc(1) complex biogenesis http://purl.obolibrary.org/obo/GO_0017062 GO:0017061 biolink:MolecularActivity S-methyl-5-thioadenosine phosphorylase activity Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. EC:2.4.2.28|MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN|RHEA:11852|Reactome:R-HSA-1237160 go.json 5'-deoxy-5'-methylthioadenosine phosphorylase activity|5'-methylthioadenosine phosphorylase activity|5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity|MTA phosphorylase activity|MTAPase activity|MeSAdo phosphorylase activity|MeSAdo/Ado phosphorylase activity|S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity|methylthioadenosine nucleoside phosphorylase activity|methylthioadenosine phosphorylase activity http://purl.obolibrary.org/obo/GO_0017061 GO:0032699 biolink:BiologicalProcess negative regulation of interleukin-16 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production. go.json down regulation of interleukin-16 production|down-regulation of interleukin-16 production|downregulation of interleukin-16 production|inhibition of interleukin-16 production|negative regulation of IL-16 production|negative regulation of interleukin-16 biosynthetic process http://purl.obolibrary.org/obo/GO_0032699 GO:0032690 biolink:BiologicalProcess negative regulation of interleukin-1 alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production. go.json down regulation of interleukin-1 alpha production|down-regulation of interleukin-1 alpha production|downregulation of interleukin-1 alpha production|inhibition of interleukin-1 alpha production|negative regulation of IL-1 alpha production|negative regulation of interleukin-1 alpha biosynthetic process|negative regulation of interleukin-1 alpha secretion http://purl.obolibrary.org/obo/GO_0032690 GO:0017057 biolink:MolecularActivity 6-phosphogluconolactonase activity Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+. EC:3.1.1.31|KEGG_REACTION:R02035|MetaCyc:6PGLUCONOLACT-RXN|RHEA:12556|Reactome:R-HSA-71296 go.json 6-PGL|6-phospho-D-glucono-1,5-lactone lactonohydrolase activity|phosphogluconolactonase activity http://purl.obolibrary.org/obo/GO_0017057 GO:0032698 biolink:BiologicalProcess negative regulation of interleukin-15 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production. go.json down regulation of interleukin-15 production|down-regulation of interleukin-15 production|downregulation of interleukin-15 production|inhibition of interleukin-15 production|negative regulation of IL-15 production|negative regulation of interleukin-15 biosynthetic process http://purl.obolibrary.org/obo/GO_0032698 GO:0032697 biolink:BiologicalProcess obsolete negative regulation of interleukin-14 production OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production. go.json down regulation of interleukin-14 production|down-regulation of interleukin-14 production|downregulation of interleukin-14 production|inhibition of interleukin-14 production|negative regulation of IL-14 production|negative regulation of interleukin-14 biosynthetic process True http://purl.obolibrary.org/obo/GO_0032697 GO:0017056 biolink:MolecularActivity structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. Reactome:R-HSA-1176059|Reactome:R-HSA-170796|Reactome:R-HSA-192627|Reactome:R-HSA-192925|Reactome:R-HSA-5252041|Reactome:R-HSA-5578744|Reactome:R-HSA-5661474|Reactome:R-HSA-6783483 go.json nuclear pore activity|nucleocytoplasmic transporter activity http://purl.obolibrary.org/obo/GO_0017056 GO:0032696 biolink:BiologicalProcess negative regulation of interleukin-13 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production. go.json down regulation of interleukin-13 production|down-regulation of interleukin-13 production|downregulation of interleukin-13 production|inhibition of interleukin-13 production|negative regulation of IL-13 production|negative regulation of interleukin-13 biosynthetic process|negative regulation of interleukin-13 secretion http://purl.obolibrary.org/obo/GO_0032696 GO:0017059 biolink:CellularComponent serine C-palmitoyltransferase complex An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine. go.json http://purl.obolibrary.org/obo/GO_0017059 GO:0032695 biolink:BiologicalProcess negative regulation of interleukin-12 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. go.json down regulation of interleukin-12 production|down-regulation of interleukin-12 production|downregulation of interleukin-12 production|inhibition of interleukin-12 production|negative regulation of CLMF production|negative regulation of IL-12 production|negative regulation of NKSF production|negative regulation of interleukin-12 biosynthetic process|negative regulation of interleukin-12 secretion http://purl.obolibrary.org/obo/GO_0032695 GO:0017058 biolink:MolecularActivity FH1 domain binding Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain. go.json http://purl.obolibrary.org/obo/GO_0017058 GO:0032694 biolink:BiologicalProcess negative regulation of interleukin-11 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production. go.json down regulation of interleukin-11 production|down-regulation of interleukin-11 production|downregulation of interleukin-11 production|inhibition of interleukin-11 production|negative regulation of IL-11 production|negative regulation of interleukin-11 biosynthetic process|negative regulation of interleukin-11 secretion http://purl.obolibrary.org/obo/GO_0032694 GO:0017053 biolink:CellularComponent transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription. go.json cytoplasmic transcriptional repressor complex|nuclear transcriptional repressor complex|transcription factor inhibitor complex|transcriptional repressor complex http://purl.obolibrary.org/obo/GO_0017053 goslim_pir GO:0017052 biolink:CellularComponent obsolete insulin-like growth factor binding protein OBSOLETE. (Was not defined before being made obsolete). go.json insulin-like growth factor binding protein True http://purl.obolibrary.org/obo/GO_0017052 GO:0032693 biolink:BiologicalProcess negative regulation of interleukin-10 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. go.json down regulation of interleukin-10 production|down-regulation of interleukin-10 production|downregulation of interleukin-10 production|inhibition of interleukin-10 production|negative regulation of IL-10 production|negative regulation of interleukin-10 biosynthetic process|negative regulation of interleukin-10 secretion http://purl.obolibrary.org/obo/GO_0032693 GO:0017055 biolink:BiologicalProcess negative regulation of RNA polymerase II transcription preinitiation complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. go.json down regulation of RNA polymerase II transcriptional preinitiation complex assembly|down-regulation of RNA polymerase II transcriptional preinitiation complex assembly|downregulation of RNA polymerase II transcriptional preinitiation complex assembly|inhibition of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly|negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of RNA polymerase II transcriptional preinitiation complex formation http://purl.obolibrary.org/obo/GO_0017055 GO:0032692 biolink:BiologicalProcess negative regulation of interleukin-1 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. go.json down regulation of interleukin-1 production|down-regulation of interleukin-1 production|downregulation of interleukin-1 production|inhibition of interleukin-1 production|negative regulation of IL-1 production|negative regulation of interleukin-1 biosynthetic process|negative regulation of interleukin-1 secretion http://purl.obolibrary.org/obo/GO_0032692 GO:0032691 biolink:BiologicalProcess negative regulation of interleukin-1 beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. go.json down regulation of interleukin-1 beta production|down-regulation of interleukin-1 beta production|downregulation of interleukin-1 beta production|inhibition of interleukin-1 beta production|negative regulation of IL-1 beta production|negative regulation of interleukin-1 beta biosynthetic process|negative regulation of interleukin-1 beta secretion http://purl.obolibrary.org/obo/GO_0032691 GO:0017054 biolink:CellularComponent negative cofactor 2 complex A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. go.json http://purl.obolibrary.org/obo/GO_0017054 GO:0017071 biolink:CellularComponent intracellular cyclic nucleotide activated cation channel complex A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0017071 GO:0017070 biolink:MolecularActivity U6 snRNA binding Binding to a U6 small nuclear RNA (U6 snRNA). go.json http://purl.obolibrary.org/obo/GO_0017070 GO:0017073 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017073 GO:0017072 biolink:MolecularActivity obsolete tubulin-specific chaperone activity OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function. go.json tubulin-specific chaperone activity True http://purl.obolibrary.org/obo/GO_0017072 GO:0032689 biolink:BiologicalProcess negative regulation of type II interferon production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. go.json down regulation of interferon-gamma production|down-regulation of interferon-gamma production|downregulation of interferon-gamma production|inhibition of interferon-gamma production|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interferon-gamma secretion http://purl.obolibrary.org/obo/GO_0032689 GO:0032688 biolink:BiologicalProcess negative regulation of interferon-beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. go.json down regulation of interferon-beta production|down-regulation of interferon-beta production|downregulation of interferon-beta production|inhibition of interferon-beta production|negative regulation of IFN-beta production|negative regulation of interferon-beta biosynthetic process|negative regulation of interferon-beta secretion http://purl.obolibrary.org/obo/GO_0032688 GO:0032687 biolink:BiologicalProcess negative regulation of interferon-alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production. go.json down regulation of interferon-alpha production|down-regulation of interferon-alpha production|downregulation of interferon-alpha production|inhibition of interferon-alpha production|negative regulation of interferon-alpha biosynthetic process|negative regulation of interferon-alpha secretion http://purl.obolibrary.org/obo/GO_0032687 GO:0017068 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017068 GO:0017067 biolink:MolecularActivity tyrosine-ester sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+. EC:2.8.2.9|KEGG_REACTION:R04213|MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN|RHEA:19977 go.json 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity|L-tyrosine methyl ester sulfotransferase activity|aryl sulfotransferase IV|tyrosine-ester sulphotransferase activity http://purl.obolibrary.org/obo/GO_0017067 GO:0032686 biolink:BiologicalProcess negative regulation of hepatocyte growth factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production. go.json down regulation of hepatocyte growth factor production|down-regulation of hepatocyte growth factor production|downregulation of hepatocyte growth factor production|inhibition of hepatocyte growth factor production|negative regulation of HGF production|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of scatter factor production http://purl.obolibrary.org/obo/GO_0032686 GO:0032685 biolink:BiologicalProcess negative regulation of granulocyte macrophage colony-stimulating factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. go.json down regulation of granulocyte macrophage colony-stimulating factor production|down-regulation of granulocyte macrophage colony-stimulating factor production|downregulation of granulocyte macrophage colony-stimulating factor production|inhibition of granulocyte macrophage colony-stimulating factor production|negative regulation of GM-CSF production|negative regulation of granulocyte macrophage colony stimulating factor production|negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process http://purl.obolibrary.org/obo/GO_0032685 GO:0017069 biolink:MolecularActivity snRNA binding Binding to a small nuclear RNA (snRNA). go.json base pairing with snRNA|small nuclear RNA binding http://purl.obolibrary.org/obo/GO_0017069 GO:0032684 biolink:BiologicalProcess negative regulation of fractalkine production Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production. go.json down regulation of fractalkine production|down-regulation of fractalkine production|downregulation of fractalkine production|inhibition of fractalkine production|negative regulation of CX3CL1 biosynthesis|negative regulation of CX3CL1 production|negative regulation of fractalkine biosynthetic process http://purl.obolibrary.org/obo/GO_0032684 GO:0017064 biolink:MolecularActivity fatty acid amide hydrolase activity Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. EC:3.5.1.99|MetaCyc:RXN-10756|MetaCyc:RXN6666-2|Reactome:R-HSA-5693742|Reactome:R-HSA-5693751 go.json anandamide amidohydrolase activity|oleamide hydrolase activity http://purl.obolibrary.org/obo/GO_0017064 GO:0032683 biolink:BiologicalProcess negative regulation of connective tissue growth factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production. go.json down regulation of connective tissue growth factor production|down-regulation of connective tissue growth factor production|downregulation of connective tissue growth factor production|inhibition of connective tissue growth factor production|negative regulation of CCN2 production|negative regulation of CTGF production|negative regulation of Fisp12 production|negative regulation of Hcs24 production|negative regulation of IGFBP8 production|negative regulation of connective tissue growth factor biosynthetic process|negative regulation of hypertrophic chondrocyte-specific gene product 24 production http://purl.obolibrary.org/obo/GO_0032683 GO:0032682 biolink:BiologicalProcess negative regulation of chemokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. go.json down regulation of chemokine production|down-regulation of chemokine production|downregulation of chemokine production|inhibition of chemokine production|negative regulation of chemokine biosynthetic process|negative regulation of chemokine secretion http://purl.obolibrary.org/obo/GO_0032682 GO:0017063 biolink:MolecularActivity obsolete phosphatidylserine-specific phospholipase A1 activity OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion. go.json phosphatidylserine-specific phospholipase A1 activity True http://purl.obolibrary.org/obo/GO_0017063 GO:0032681 biolink:BiologicalProcess regulation of lymphotoxin A production Any process that modulates the frequency, rate, or extent of lymphotoxin A production. go.json regulation of LTA production|regulation of TNF-beta production|regulation of lymphotoxin A biosynthetic process|regulation of lymphotoxin-alpha production|regulation of tumor necrosis factor-beta production http://purl.obolibrary.org/obo/GO_0032681 GO:0017066 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017066 GO:0032680 biolink:BiologicalProcess regulation of tumor necrosis factor production Any process that modulates the frequency, rate or extent of tumor necrosis factor production. go.json regulation of TNF production|regulation of TNF-alpha production|regulation of cachectin production|regulation of tumor necrosis factor biosynthetic process|regulation of tumor necrosis factor secretion|regulation of tumor necrosis factor-alpha production http://purl.obolibrary.org/obo/GO_0032680 GO:0017065 biolink:MolecularActivity single-strand selective uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA. Reactome:R-HSA-110221 go.json single-strand selective monofunctional uracil-DNA glycosylase activity http://purl.obolibrary.org/obo/GO_0017065 GO:0140588 biolink:BiologicalProcess chromatin looping A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome. go.json DNA loop extrusion|DNA looping|chromatin folding|chromatin loop assembly http://purl.obolibrary.org/obo/GO_0140588 GO:0140587 biolink:MolecularActivity chromatin loop anchoring activity Bridging together two DNA loop anchors together, maintaining a chromatin loop. go.json DNA loop binding|chromosomal loop binding http://purl.obolibrary.org/obo/GO_0140587 GO:0140580 biolink:MolecularActivity mitochondrion autophagosome adaptor activity The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy. go.json mitophagy receptor http://purl.obolibrary.org/obo/GO_0140580 GO:0140582 biolink:BiologicalProcess adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by extracellular cAMP binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. go.json extracellular cAMP signaling pathway http://purl.obolibrary.org/obo/GO_0140582 GO:0140581 biolink:MolecularActivity P-type monovalent copper transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out). EC:7.2.2.8|RHEA:25792 go.json http://purl.obolibrary.org/obo/GO_0140581 GO:0140584 biolink:MolecularActivity chromatin extrusion motor activity A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis. go.json chromatin extrusion activity http://purl.obolibrary.org/obo/GO_0140584 GO:0140586 biolink:MolecularActivity promoter-terminator loop anchoring activity Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop. go.json terminator-promoter loop anchoring activity http://purl.obolibrary.org/obo/GO_0140586 GO:0140585 biolink:MolecularActivity promoter-enhancer loop anchoring activity Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop. go.json enhancer-promoter loop anchoring activity http://purl.obolibrary.org/obo/GO_0140585 GO:0140576 biolink:BiologicalProcess ascorbate homeostasis Any process involved in the maintenance of an internal steady state of ascorbate at the level of a cell. go.json cellular ascorbate homeostasis http://purl.obolibrary.org/obo/GO_0140576 GO:0140579 biolink:MolecularActivity obsolete oxidoreductase activity, reducing metal ions OBSOLETE. Catalysis of an oxidation-reduction in which the metal ion is reduced. go.json True http://purl.obolibrary.org/obo/GO_0140579 GO:0140571 biolink:MolecularActivity transmembrane ascorbate ferrireductase activity Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. EC:7.2.1.3|MetaCyc:1.10.2.1-RXN|RHEA:30403 go.json L-ascorbate-cytochrome-b5 reductase activity|L-ascorbate:ferricytochrome-b5 oxidoreductase activity|ascorbate-cytochrome b5 reductase activity http://purl.obolibrary.org/obo/GO_0140571 GO:0140570 biolink:BiologicalProcess extraction of mislocalized protein from mitochondrial outer membrane The removal of a mislocalized protein from the mitochondrial outer membrane. go.json extraction of mislocalized protein from outer mitochondrion membrane http://purl.obolibrary.org/obo/GO_0140570 GO:0140573 biolink:CellularComponent histone H3-containing nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures. go.json histone H3 containing nucleosome http://purl.obolibrary.org/obo/GO_0140573 GO:0140572 biolink:BiologicalProcess vacuole fission The division of a vacuole within a cell to form two or more separate vacuoles. go.json http://purl.obolibrary.org/obo/GO_0140572 GO:0140575 biolink:MolecularActivity transmembrane monodehydroascorbate reductase activity Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. RHEA:66524 go.json http://purl.obolibrary.org/obo/GO_0140575 GO:0140599 biolink:CellularComponent mitotic nuclear bridge midzone membrane domain A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets. go.json http://purl.obolibrary.org/obo/GO_0140599 GO:0140598 biolink:MolecularActivity lipoprotein carrier activity Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein. go.json http://purl.obolibrary.org/obo/GO_0140598 GO:0140591 biolink:BiologicalProcess nuclear envelope budding The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0140591 GO:0140590 biolink:BiologicalProcess effector-mediated suppression of host defense response A process mediated by a molecule secreted by a symbiont that results in the supression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json effector-mediated suppression of host defenses|effector-mediated suppression of host defenses by symbiont http://purl.obolibrary.org/obo/GO_0140590 GO:0140593 biolink:CellularComponent host apoplast The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json host cell apoplast http://purl.obolibrary.org/obo/GO_0140593 GO:0140592 biolink:MolecularActivity histone H3R8 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3. go.json histone H3R8 arginine methylase activity|histone H3R8 arginine methyltransferase activity|histone methyltransferase activity (H3-R8 specific)|histone-H3R8 methyltransferase activity http://purl.obolibrary.org/obo/GO_0140592 GO:0140595 biolink:CellularComponent MIM complex A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2. go.json mitochondrial outer import machinery http://purl.obolibrary.org/obo/GO_0140595 GO:0140594 biolink:MolecularActivity xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase. go.json http://purl.obolibrary.org/obo/GO_0140594 GO:0140597 biolink:MolecularActivity protein carrier chaperone Binding to and carrying a protein between two different cellular components by moving along with the target protein. go.json protein carrier activity|protein chaperone http://purl.obolibrary.org/obo/GO_0140597 GO:0140596 biolink:CellularComponent TOM complex A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane. go.json translocase of the outer mitochondrial membrane http://purl.obolibrary.org/obo/GO_0140596 GO:0140544 biolink:BiologicalProcess septin collar organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar. go.json cellular bud neck septin hourglass organization http://purl.obolibrary.org/obo/GO_0140544 GO:0140543 biolink:BiologicalProcess positive regulation of piRNA transcription Any process that increases the frequency, rate or extent of the synthesis of piRNA. go.json http://purl.obolibrary.org/obo/GO_0140543 GO:0140546 biolink:BiologicalProcess defense response to symbiont Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont. go.json http://purl.obolibrary.org/obo/GO_0140546 GO:0140545 biolink:MolecularActivity ATP-dependent protein disaggregase activity An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates. go.json protein disaggregase activity|protein unfoldase activity http://purl.obolibrary.org/obo/GO_0140545 GO:0140548 biolink:BiologicalProcess envenomation resulting in blood agglutination in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism. go.json envenomation resulting in blood agglutination in other organism|envenomation resulting in erythrocytes agglutination in other organism|envenomation resulting in red blood cells agglutination in other organism http://purl.obolibrary.org/obo/GO_0140548 GO:0140547 biolink:BiologicalProcess acquisition of seed longevity The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes. go.json http://purl.obolibrary.org/obo/GO_0140547 GO:0140549 biolink:CellularComponent spore inner membrane The membrane surrounding the spore core (endospore core) that separates it from its external environment. go.json spore membrane http://purl.obolibrary.org/obo/GO_0140549 GO:0140540 biolink:BiologicalProcess negative regulation melanotic encapsulation of foreign target Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target. go.json http://purl.obolibrary.org/obo/GO_0140540 GO:0140542 biolink:BiologicalProcess regulation of piRNA transcription Any process that modulates the frequency, rate or extent of the synthesis of a piRNA. go.json http://purl.obolibrary.org/obo/GO_0140542 GO:0140541 biolink:BiologicalProcess piRNA transcription The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. go.json PIWI-interacting RNA transcription|Piwi-associated RNA transcription http://purl.obolibrary.org/obo/GO_0140541 GO:0140533 biolink:BiologicalProcess suppression of host RNAi-mediated antiviral immune response Any process in which a symbiont stops, prevents, or reduces the rate or extent of the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json suppression of host RNAi-mediated antiviral immunity|suppression of host RNAi-mediated gene silencing http://purl.obolibrary.org/obo/GO_0140533 GO:0140532 biolink:BiologicalProcess negative regulation of osmosensory signaling MAPK cascade Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling MAPK cascade. go.json http://purl.obolibrary.org/obo/GO_0140532 GO:0140535 biolink:CellularComponent intracellular protein-containing complex A protein-containing complex located intracellularly. go.json http://purl.obolibrary.org/obo/GO_0140535 GO:0140534 biolink:CellularComponent endoplasmic reticulum protein-containing complex A protein complex that is part of an endoplasmic reticulum. go.json http://purl.obolibrary.org/obo/GO_0140534 GO:0140537 biolink:MolecularActivity transcription regulator activator activity A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification. go.json http://purl.obolibrary.org/obo/GO_0140537 GO:0140536 biolink:MolecularActivity nuclear receptor corepressor activity A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. go.json nuclear corepressor activity http://purl.obolibrary.org/obo/GO_0140536 GO:0140539 biolink:BiologicalProcess regulation of melanotic encapsulation of foreign target Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target. go.json http://purl.obolibrary.org/obo/GO_0140539 GO:0140538 biolink:BiologicalProcess negative regulation of conjugation with zygote A process that prevents a zygote from fusing an additional cell. go.json http://purl.obolibrary.org/obo/GO_0140538 GO:0140531 biolink:BiologicalProcess regulation of osmosensory signaling MAPK cascade Any process that modulates the frequency, rate or extent of osmosensory signaling MAPK cascade. go.json http://purl.obolibrary.org/obo/GO_0140531 GO:0140530 biolink:BiologicalProcess MCM complex loading The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly. go.json MCM complex loading at replication origin|MCM double hexamer formation at replication origin http://purl.obolibrary.org/obo/GO_0140530 GO:0140566 biolink:MolecularActivity histone reader activity A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. go.json epigenetic reader|histone reader http://purl.obolibrary.org/obo/GO_0140566 GO:0140568 biolink:BiologicalProcess extraction of mislocalized protein from membrane The removal of a mislocalized protein from a cellular membrane. go.json http://purl.obolibrary.org/obo/GO_0140568 GO:0140567 biolink:MolecularActivity membrane protein dislocase activity The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis. go.json transmembrane helix dislocase transmembrane protein dislocase activity http://purl.obolibrary.org/obo/GO_0140567 GO:0140569 biolink:BiologicalProcess extraction of mislocalized protein from ER membrane The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane. go.json http://purl.obolibrary.org/obo/GO_0140569 GO:0140560 biolink:MolecularActivity xylosyl alpha-1,3-xylosyltransferase activity Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains. EC:2.4.2.62|RHEA:22820 go.json http://purl.obolibrary.org/obo/GO_0140560 GO:0140562 biolink:MolecularActivity EGF-domain serine xylosyltransferase activity Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine. EC:2.4.2.63|RHEA:62016 go.json http://purl.obolibrary.org/obo/GO_0140562 GO:0140561 biolink:MolecularActivity EGF-domain serine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine. EC:2.4.1.376|RHEA:58116 go.json http://purl.obolibrary.org/obo/GO_0140561 GO:0140564 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140564 GO:0140563 biolink:MolecularActivity UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. EC:2.4.2.42|RHEA:56064 go.json http://purl.obolibrary.org/obo/GO_0140563 GO:0140554 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140554 GO:0140550 biolink:MolecularActivity phosphatidylinositol-4,5-bisphosphate sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate. go.json phosphatidylinositol-4,5-bisphosphate sensing activity http://purl.obolibrary.org/obo/GO_0140550 GO:0140552 biolink:CellularComponent TEAD-YAP complex A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP. CORUM:2870 go.json TEAD-1-YAP complex|TEAD-2 multiprotein complex|TEAD-2-YAP complex|TEAD-3-YAP complex|TEAD-4-YAP complex http://purl.obolibrary.org/obo/GO_0140552 GO:0007639 biolink:BiologicalProcess homeostasis of number of meristem cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem. go.json http://purl.obolibrary.org/obo/GO_0007639 GO:0007638 biolink:BiologicalProcess mechanosensory behavior Behavior that is dependent upon the sensation of a mechanical stimulus. go.json behavioral response to mechanical stimulus|behavioural response to mechanical stimulus|mechanosensory behaviour http://purl.obolibrary.org/obo/GO_0007638 GO:0007637 biolink:BiologicalProcess proboscis extension reflex The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus. go.json behavioral response to nutritional stimulus, proboscis extension|proboscis extension in response to nutritional stimulus http://purl.obolibrary.org/obo/GO_0007637 GO:0007636 biolink:BiologicalProcess chemosensory jump behavior The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance. go.json chemosensory jump behaviour|jump response to chemical stimulus http://purl.obolibrary.org/obo/GO_0007636 GO:0007635 biolink:BiologicalProcess chemosensory behavior Behavior that is dependent upon the sensation of chemicals. go.json behavioral response to chemical stimulus|behavioural response to chemical stimulus|chemosensory behaviour http://purl.obolibrary.org/obo/GO_0007635 GO:0007634 biolink:BiologicalProcess optokinetic behavior The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus. go.json optokinetic behaviour http://purl.obolibrary.org/obo/GO_0007634 GO:0007633 biolink:BiologicalProcess pattern orientation The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes. go.json behavioral response to pattern orientation|behavioural response to pattern orientation http://purl.obolibrary.org/obo/GO_0007633 GO:0007632 biolink:BiologicalProcess visual behavior The behavior of an organism in response to a visual stimulus. go.json behavioral response to visual stimulus|behavioural response to visual stimulus|visual behaviour http://purl.obolibrary.org/obo/GO_0007632 GO:0007631 biolink:BiologicalProcess feeding behavior Behavior associated with the intake of food. Wikipedia:List_of_feeding_behaviours go.json behavioral response to food|behavioural response to food|eating|feeding behaviour|feeding from phloem of other organism|feeding from plant phloem|feeding from tissue of other organism|feeding from vascular tissue of another organism|feeding from xylem of other organism|feeding on blood of other organism|feeding on or from other organism|feeding on plant sap|hematophagy|injection of substance into other organism during feeding on blood of other organism|taking of blood meal http://purl.obolibrary.org/obo/GO_0007631 GO:0007630 biolink:BiologicalProcess jump response The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0007630 GO:0007618 biolink:BiologicalProcess mating The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. go.json http://purl.obolibrary.org/obo/GO_0007618 GO:0007617 biolink:BiologicalProcess mating behavior The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. Wikipedia:Mating_behaviour go.json mating behaviour http://purl.obolibrary.org/obo/GO_0007617 GO:0007616 biolink:BiologicalProcess long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. Wikipedia:Long-term_memory go.json http://purl.obolibrary.org/obo/GO_0007616 GO:0007615 biolink:BiologicalProcess anesthesia-resistant memory The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis. go.json http://purl.obolibrary.org/obo/GO_0007615 GO:0007614 biolink:BiologicalProcess short-term memory The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. Wikipedia:Short-term_memory go.json http://purl.obolibrary.org/obo/GO_0007614 GO:0007613 biolink:BiologicalProcess memory The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). Wikipedia:Memory go.json http://purl.obolibrary.org/obo/GO_0007613 GO:0007612 biolink:BiologicalProcess learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. Wikipedia:Learning go.json http://purl.obolibrary.org/obo/GO_0007612 GO:0007611 biolink:BiologicalProcess learning or memory The acquisition and processing of information and/or the storage and retrieval of this information over time. go.json http://purl.obolibrary.org/obo/GO_0007611 GO:0007610 biolink:BiologicalProcess behavior The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. Wikipedia:Behavior go.json behavioral response to stimulus|behaviour|behavioural response to stimulus|single-organism behavior http://purl.obolibrary.org/obo/GO_0007610 gocheck_do_not_manually_annotate|goslim_agr|goslim_flybase_ribbon GO:0007619 biolink:BiologicalProcess courtship behavior The behavior of an organism for the purpose of attracting sexual partners. go.json courtship behaviour http://purl.obolibrary.org/obo/GO_0007619 GO:0007629 biolink:BiologicalProcess flight behavior The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air. go.json flight behaviour http://purl.obolibrary.org/obo/GO_0007629 GO:0007628 biolink:BiologicalProcess adult walking behavior The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. go.json adult walking behaviour http://purl.obolibrary.org/obo/GO_0007628 GO:0007627 biolink:BiologicalProcess obsolete larval behavior (sensu Insecta) OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects. go.json larval behavior (sensu Insecta) True http://purl.obolibrary.org/obo/GO_0007627 GO:0007626 biolink:BiologicalProcess locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. go.json behavior via locomotion|locomotion in response to stimulus|locomotory behavioral response to stimulus|locomotory behaviour|locomotory behavioural response to stimulus http://purl.obolibrary.org/obo/GO_0007626 goslim_drosophila GO:0007625 biolink:BiologicalProcess grooming behavior The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. go.json grooming behaviour http://purl.obolibrary.org/obo/GO_0007625 GO:0007624 biolink:BiologicalProcess ultradian rhythm The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours. go.json http://purl.obolibrary.org/obo/GO_0007624 GO:0007623 biolink:BiologicalProcess circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours. Wikipedia:Circadian_rhythm go.json circadian process|circadian response|response to circadian rhythm http://purl.obolibrary.org/obo/GO_0007623 goslim_drosophila|goslim_plant GO:0007622 biolink:BiologicalProcess rhythmic behavior The specific behavior of an organism that recur with measured regularity. go.json rhythmic behavioral response to stimulus|rhythmic behaviour|rhythmic behavioural response to stimulus http://purl.obolibrary.org/obo/GO_0007622 GO:0007621 biolink:BiologicalProcess negative regulation of female receptivity Any process that stops, prevents or reduces the receptiveness of a female to male advances. go.json down regulation of female receptivity|down-regulation of female receptivity|downregulation of female receptivity|inhibition of female receptivity http://purl.obolibrary.org/obo/GO_0007621 GO:0007620 biolink:BiologicalProcess copulation The act of sexual union between male and female, involving the transfer of sperm. go.json http://purl.obolibrary.org/obo/GO_0007620 GO:0007607 biolink:BiologicalProcess obsolete taste perception OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal. go.json taste perception True http://purl.obolibrary.org/obo/GO_0007607 GO:0007606 biolink:BiologicalProcess sensory perception of chemical stimulus The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. go.json chemosensory perception http://purl.obolibrary.org/obo/GO_0007606 GO:0007605 biolink:BiologicalProcess sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. Wikipedia:Hearing_(sense) go.json hearing|perception of sound http://purl.obolibrary.org/obo/GO_0007605 GO:0007604 biolink:BiologicalProcess phototransduction, UV The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers. go.json UV-sensitive opsin|phototransduction, UV light|phototransduction, UV radiation|phototransduction, ultraviolet light|phototransduction, ultraviolet radiation http://purl.obolibrary.org/obo/GO_0007604 GO:0007603 biolink:BiologicalProcess phototransduction, visible light The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. go.json visual cascade|visual transduction http://purl.obolibrary.org/obo/GO_0007603 GO:0007602 biolink:BiologicalProcess phototransduction The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. Wikipedia:Visual_phototransduction go.json opsin|phototransduction, visible light, light adaptation|phototrophin mediated phototransduction http://purl.obolibrary.org/obo/GO_0007602 GO:0007601 biolink:BiologicalProcess visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. Wikipedia:Visual_perception go.json sense of sight|sensory visual perception|vision http://purl.obolibrary.org/obo/GO_0007601 GO:0007600 biolink:BiologicalProcess sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Wikipedia:Perception go.json http://purl.obolibrary.org/obo/GO_0007600 goslim_drosophila GO:0007609 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007609 GO:0007608 biolink:BiologicalProcess sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. Wikipedia:Olfaction go.json olfaction|scent perception|sense of smell|smell perception http://purl.obolibrary.org/obo/GO_0007608 GO:0017161 biolink:MolecularActivity inositol-1,3,4-trisphosphate 4-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate. RHEA:43392|Reactome:R-HSA-1855180 go.json http://purl.obolibrary.org/obo/GO_0017161 GO:0017160 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017160 GO:0032799 biolink:BiologicalProcess low-density lipoprotein receptor particle metabolic process The chemical reactions and pathways involving low-density lipoprotein receptors. go.json LDL receptor metabolic process|low-density lipoprotein receptor metabolic process|low-density lipoprotein receptor metabolism http://purl.obolibrary.org/obo/GO_0032799 GO:0032798 biolink:CellularComponent Swi5-Sfr1 complex A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces). go.json Sae3-Mei5 complex|Swi5 complex http://purl.obolibrary.org/obo/GO_0032798 GO:0042123 biolink:MolecularActivity glucanosyltransferase activity Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation. go.json http://purl.obolibrary.org/obo/GO_0042123 GO:0042122 biolink:BiologicalProcess alginic acid catabolic process The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). go.json alginate catabolic process|alginate catabolism|alginic acid breakdown|alginic acid catabolism|alginic acid degradation http://purl.obolibrary.org/obo/GO_0042122 GO:0042125 biolink:BiologicalProcess protein galactosylation The addition of a galactose molecule to a protein amino acid. go.json protein amino acid galactosylation http://purl.obolibrary.org/obo/GO_0042125 GO:0042124 biolink:MolecularActivity 1,3-beta-glucanosyltransferase activity Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation. go.json http://purl.obolibrary.org/obo/GO_0042124 GO:0042121 biolink:BiologicalProcess alginic acid biosynthetic process The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). go.json alginate biosynthesis|alginate biosynthetic process|alginic acid anabolism|alginic acid biosynthesis|alginic acid formation|alginic acid synthesis http://purl.obolibrary.org/obo/GO_0042121 GO:0042120 biolink:BiologicalProcess alginic acid metabolic process The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). go.json alginate metabolic process|alginate metabolism|alginic acid metabolism http://purl.obolibrary.org/obo/GO_0042120 GO:0042127 biolink:BiologicalProcess regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation. go.json regulation of cell proliferation http://purl.obolibrary.org/obo/GO_0042127 GO:0042126 biolink:BiologicalProcess nitrate metabolic process The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. go.json nitrate metabolism http://purl.obolibrary.org/obo/GO_0042126 GO:0017159 biolink:MolecularActivity pantetheine hydrolase activity Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine. EC:3.5.1.92|KEGG_REACTION:R02973|MetaCyc:3.5.1.92-RXN|RHEA:13445|Reactome:R-HSA-8938300 go.json (R)-pantetheine amidohydrolase activity|pantetheinase activity|vanin|vanin-1 http://purl.obolibrary.org/obo/GO_0017159 GO:0042129 biolink:BiologicalProcess regulation of T cell proliferation Any process that modulates the frequency, rate or extent of T cell proliferation. go.json regulation of T lymphocyte proliferation|regulation of T-cell proliferation|regulation of T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0042129 GO:0042128 biolink:BiologicalProcess nitrate assimilation The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances. MetaCyc:PWY-381 go.json assimilatory nitrate reduction http://purl.obolibrary.org/obo/GO_0042128 GO:0017156 biolink:BiologicalProcess calcium-ion regulated exocytosis The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. go.json calcium ion-dependent exocytosis http://purl.obolibrary.org/obo/GO_0017156 GO:0032797 biolink:CellularComponent SMN complex A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. go.json SMN core complex|survival motor neuron complex http://purl.obolibrary.org/obo/GO_0032797 GO:0017155 biolink:MolecularActivity obsolete sodium:hydrogen antiporter regulator activity OBSOLETE. This term was not defined before being made obsolete. go.json sodium:hydrogen antiporter regulator activity|sodium:proton antiporter regulator True http://purl.obolibrary.org/obo/GO_0017155 GO:0032796 biolink:BiologicalProcess uropod organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated. go.json uropod organisation|uropod organization and biogenesis http://purl.obolibrary.org/obo/GO_0032796 GO:0017158 biolink:BiologicalProcess regulation of calcium ion-dependent exocytosis Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. go.json http://purl.obolibrary.org/obo/GO_0017158 GO:0032795 biolink:MolecularActivity heterotrimeric G-protein binding Binding to a heterotrimeric G-protein. go.json http://purl.obolibrary.org/obo/GO_0032795 GO:0017157 biolink:BiologicalProcess regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis. go.json http://purl.obolibrary.org/obo/GO_0017157 GO:0032794 biolink:MolecularActivity GTPase activating protein binding Binding to a GTPase activating protein. go.json GAP binding http://purl.obolibrary.org/obo/GO_0032794 GO:0032793 biolink:BiologicalProcess positive regulation of CREB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. go.json CREB activator|activation of CREB|activation of CREB transcription factor http://purl.obolibrary.org/obo/GO_0032793 gocheck_do_not_annotate GO:0017152 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017152 GO:0017151 biolink:MolecularActivity DEAD/H-box RNA helicase binding Binding to a DEAD/H-box RNA helicase. go.json http://purl.obolibrary.org/obo/GO_0017151 GO:0032792 biolink:BiologicalProcess negative regulation of CREB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB. go.json CREB inhibitor|inhibition of CREB transcription factor http://purl.obolibrary.org/obo/GO_0032792 gocheck_do_not_annotate GO:0032791 biolink:MolecularActivity lead ion binding Binding to lead (Pb) ions. go.json http://purl.obolibrary.org/obo/GO_0032791 GO:0017154 biolink:MolecularActivity semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json http://purl.obolibrary.org/obo/GO_0017154 GO:0017153 biolink:MolecularActivity sodium:dicarboxylate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). go.json sodium:dicarboxylate cotransporter activity http://purl.obolibrary.org/obo/GO_0017153 GO:0032790 biolink:BiologicalProcess ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. go.json ribosome dissociation factor|ribosome recycling http://purl.obolibrary.org/obo/GO_0032790 GO:0017170 biolink:MolecularActivity obsolete KU70 binding OBSOLETE. Binding to Ku70, a protein involved in non-homologous DNA end joining. go.json KU70 binding True http://purl.obolibrary.org/obo/GO_0017170 GO:0017172 biolink:MolecularActivity cysteine dioxygenase activity Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+. EC:1.13.11.20|KEGG_REACTION:R00893|MetaCyc:CYSTEINE-DIOXYGENASE-RXN|RHEA:20441|Reactome:R-HSA-1614645 go.json http://purl.obolibrary.org/obo/GO_0017172 GO:0017171 biolink:MolecularActivity serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). go.json http://purl.obolibrary.org/obo/GO_0017171 GO:0032789 biolink:BiologicalProcess unsaturated monocarboxylic acid metabolic process The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds. go.json unsaturated monocarboxylate metabolic process|unsaturated monocarboxylic acid metabolism http://purl.obolibrary.org/obo/GO_0032789 GO:0032788 biolink:BiologicalProcess saturated monocarboxylic acid metabolic process The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds. go.json saturated monocarboxylate metabolic process|saturated monocarboxylic acid metabolism http://purl.obolibrary.org/obo/GO_0032788 GO:0032787 biolink:BiologicalProcess monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). go.json monocarboxylate metabolic process|monocarboxylic acid metabolism http://purl.obolibrary.org/obo/GO_0032787 goslim_yeast GO:0042134 biolink:MolecularActivity rRNA primary transcript binding Binding to an unprocessed ribosomal RNA transcript. go.json pre-rRNA binding http://purl.obolibrary.org/obo/GO_0042134 GO:0042133 biolink:BiologicalProcess obsolete neurotransmitter metabolic process OBSOLETE. The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. go.json neurotransmitter metabolism True http://purl.obolibrary.org/obo/GO_0042133 GO:0042136 biolink:BiologicalProcess obsolete neurotransmitter biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. go.json neurotransmitter anabolism|neurotransmitter biosynthesis|neurotransmitter biosynthesis and storage|neurotransmitter biosynthetic process and storage|neurotransmitter formation|neurotransmitter synthesis True http://purl.obolibrary.org/obo/GO_0042136 GO:0042135 biolink:BiologicalProcess obsolete neurotransmitter catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. go.json neurotransmitter breakdown|neurotransmitter catabolism|neurotransmitter degradation True http://purl.obolibrary.org/obo/GO_0042135 GO:0042130 biolink:BiologicalProcess negative regulation of T cell proliferation Any process that stops, prevents or reduces the rate or extent of T cell proliferation. go.json down regulation of T cell proliferation|down-regulation of T cell proliferation|downregulation of T cell proliferation|inhibition of T cell proliferation|negative regulation of T lymphocyte proliferation|negative regulation of T-cell proliferation|negative regulation of T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0042130 GO:0042132 biolink:MolecularActivity fructose 1,6-bisphosphate 1-phosphatase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. EC:3.1.3.11|MetaCyc:F16BDEPHOS-RXN|RHEA:11064|Reactome:R-HSA-70479 go.json D-fructose 1,6-diphosphatase activity|D-fructose-1,6-bisphosphate 1-phosphohydrolase activity|D-fructose-1,6-bisphosphate phosphatase activity|FBPase activity|fructose 1,6-bisphosphatase activity|fructose 1,6-bisphosphate phosphatase activity|fructose 1,6-diphosphatase activity|fructose 1,6-diphosphate phosphatase activity|fructose bisphosphate phosphatase activity|fructose diphosphatase activity|fructose diphosphate phosphatase activity|fructose-1,6-bisphosphatase activity|fructose-bisphosphatase activity|hexose bisphosphatase activity|hexose diphosphatase activity|hexosediphosphatase activity http://purl.obolibrary.org/obo/GO_0042132 GO:0042131 biolink:MolecularActivity thiamine phosphate phosphatase activity Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate. EC:3.1.3.100|RHEA:47948 go.json ThMPase|thiamin monophosphate phosphatase|thiamin phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0042131 GO:0042138 biolink:BiologicalProcess meiotic DNA double-strand break formation The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. go.json http://purl.obolibrary.org/obo/GO_0042138 GO:0042137 biolink:BiologicalProcess sequestering of neurotransmitter The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system. go.json neurotransmitter biosynthesis and storage|neurotransmitter biosynthetic process and storage|neurotransmitter retention|neurotransmitter sequestration|neurotransmitter storage|retention of neurotransmitter|sequestration of neurotransmitter|storage of neurotransmitter http://purl.obolibrary.org/obo/GO_0042137 GO:0042139 biolink:BiologicalProcess early meiotic recombination nodule assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene. go.json http://purl.obolibrary.org/obo/GO_0042139 GO:0017167 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017167 GO:0032786 biolink:BiologicalProcess positive regulation of DNA-templated transcription, elongation Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. go.json activation of RNA elongation|positive regulation of DNA-dependent transcription, elongation|positive regulation of transcription elongation|positive regulation of transcription elongation, DNA-dependent|positive regulation of transcriptional elongation|positive transcription elongation regulator activity|stimulation of RNA elongation|up regulation of RNA elongation|up-regulation of RNA elongation|upregulation of RNA elongation http://purl.obolibrary.org/obo/GO_0032786 GO:0032785 biolink:BiologicalProcess negative regulation of DNA-templated transcription, elongation Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. go.json down regulation of RNA elongation|down-regulation of RNA elongation|downregulation of RNA elongation|inhibition of RNA elongation|negative regulation of DNA-dependent transcription, elongation|negative regulation of transcription elongation|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcriptional elongation|negative transcription elongation regulator activity http://purl.obolibrary.org/obo/GO_0032785 GO:0017166 biolink:MolecularActivity vinculin binding Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0017166 GO:0032784 biolink:BiologicalProcess regulation of DNA-templated transcription elongation Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. go.json regulation of DNA-dependent transcription, elongation|regulation of DNA-templated transcription, elongation|regulation of RNA elongation|regulation of transcription elongation, DNA-dependent|regulation of transcriptional elongation|transcription elongation regulator activity http://purl.obolibrary.org/obo/GO_0032784 GO:0017169 biolink:MolecularActivity CDP-alcohol phosphatidyltransferase activity Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. go.json http://purl.obolibrary.org/obo/GO_0017169 GO:0017168 biolink:MolecularActivity 5-oxoprolinase (ATP-hydrolyzing) activity Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate. EC:3.5.2.9|KEGG_REACTION:R00251|MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN|RHEA:10348|Reactome:R-HSA-1247935|Reactome:R-HSA-5603208|Wikipedia:5-oxoprolinase_(ATP-hydrolysing) go.json 5-OPase activity|5-oxo-L-prolinase activity|5-oxo-L-proline amidohydrolase (ATP-hydrolysing)|5-oxoprolinase (ATP-hydrolysing)|5-oxoprolinase activity|L-pyroglutamate hydrolase activity|oxoprolinase activity|pyroglutamase (ATP-hydrolysing)|pyroglutamase (ATP-hydrolyzing) activity|pyroglutamase activity|pyroglutamate hydrolase activity|pyroglutamic hydrolase activity http://purl.obolibrary.org/obo/GO_0017168 GO:0032783 biolink:CellularComponent super elongation complex A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae. go.json ELL-EAF complex|ELL-EAF-EBP complex http://purl.obolibrary.org/obo/GO_0032783 GO:0017163 biolink:MolecularActivity obsolete basal transcription repressor activity OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter. go.json basal transcription repressor activity True http://purl.obolibrary.org/obo/GO_0017163 GO:0032782 biolink:BiologicalProcess bile acid secretion The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0032782 GO:0032781 biolink:BiologicalProcess positive regulation of ATP-dependent activity Any process that activates or increases the rate of an ATP-dependent activity. go.json activation of ATPase activity|positive regulation of ATPase activity|positive regulation of adenosinetriphosphatase activity|stimulation of ATPase activity|up regulation of ATPase activity|up-regulation of ATPase activity|upregulation of ATPase activity http://purl.obolibrary.org/obo/GO_0032781 gocheck_do_not_annotate GO:0017162 biolink:MolecularActivity aryl hydrocarbon receptor binding Binding to an aryl hydrocarbon receptor. go.json http://purl.obolibrary.org/obo/GO_0017162 GO:0032780 biolink:BiologicalProcess negative regulation of ATP-dependent activity Any process that stops or reduces the rate of an ATP-dependent activity. go.json down regulation of ATPase activity|down-regulation of ATPase activity|downregulation of ATPase activity|inhibition of ATPase activity|negative regulation of ATPase activity|negative regulation of adenosinetriphosphatase activity http://purl.obolibrary.org/obo/GO_0032780 gocheck_do_not_annotate GO:0017165 biolink:MolecularActivity obsolete dipeptidase E activity OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides. go.json PepE gene product (Salmonella typhimurium) activity|alpha-aspartyl dipeptidase activity|aspartyl dipeptidase activity|dipeptidase E activity|peptidase E activity True http://purl.obolibrary.org/obo/GO_0017165 GO:0017164 biolink:MolecularActivity obsolete nicotinic acetylcholine receptor-associated protein activity OBSOLETE. (Was not defined before being made obsolete). go.json nicotinic acetylcholine receptor-associated protein activity True http://purl.obolibrary.org/obo/GO_0017164 GO:0032779 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032779 GO:0032778 biolink:MolecularActivity P-type cobalt transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in). RHEA:32779 go.json ATP-dependent cobalt transmembrane transporter activity|ATPase-coupled cobalt transmembrane transporter activity|cobalt porter activity|cobalt transporting ATPase activity|cobalt-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0032778 GO:0032777 biolink:CellularComponent piccolo histone acetyltransferase complex A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. go.json http://purl.obolibrary.org/obo/GO_0032777 GO:0032776 biolink:BiologicalProcess DNA methylation on cytosine The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule. go.json cytosine methylation http://purl.obolibrary.org/obo/GO_0032776 GO:0042145 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042145 GO:0042144 biolink:BiologicalProcess vacuole fusion, non-autophagic The fusion of two vacuole membranes to form a single vacuole. go.json homotypic vacuole fusion|homotypic vacuole fusion (non-autophagic)|homotypic vacuole fusion, non-autophagic|vacuole fusion (non-autophagic) http://purl.obolibrary.org/obo/GO_0042144 GO:0042147 biolink:BiologicalProcess retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. go.json retrograde (endosome to Golgi) transport http://purl.obolibrary.org/obo/GO_0042147 GO:0042146 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042146 GO:0042141 biolink:MolecularActivity obsolete mating pheromone exporter OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating. go.json mating pheromone exporter True http://purl.obolibrary.org/obo/GO_0042141 GO:0042140 biolink:BiologicalProcess late meiotic recombination nodule assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over. go.json http://purl.obolibrary.org/obo/GO_0042140 GO:0042143 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042143 GO:0042142 biolink:BiologicalProcess obsolete heavy metal chelation OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein. go.json heavy metal chelation True http://purl.obolibrary.org/obo/GO_0042142 GO:0017138 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017138 GO:0042149 biolink:BiologicalProcess cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. go.json http://purl.obolibrary.org/obo/GO_0042149 GO:0017137 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017137 GO:0042148 biolink:BiologicalProcess DNA strand invasion The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. go.json D-loop biosynthesis|D-loop formation|Rad51-mediated strand invasion|displacement loop biosynthesis|displacement loop formation|strand invasion http://purl.obolibrary.org/obo/GO_0042148 GO:0017139 biolink:BiologicalProcess obsolete arsenate sensitivity/resistance OBSOLETE. (Was not defined before being made obsolete). go.json arsenate sensitivity/resistance True http://purl.obolibrary.org/obo/GO_0017139 GO:0017134 biolink:MolecularActivity fibroblast growth factor binding Binding to a fibroblast growth factor. go.json FGF 1 binding|FGF 2 binding|FGF 3 binding|FGF 4 binding|FGF 5 binding|FGF 6 binding|FGF binding|fibroblast growth factor 1 binding|fibroblast growth factor 2 binding|fibroblast growth factor 3 binding|fibroblast growth factor 4 binding|fibroblast growth factor 5 binding|fibroblast growth factor 6 binding http://purl.obolibrary.org/obo/GO_0017134 GO:0032775 biolink:BiologicalProcess DNA methylation on adenine The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule. go.json adenine methylation http://purl.obolibrary.org/obo/GO_0032775 GO:0032774 biolink:BiologicalProcess RNA biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. go.json RNA anabolism|RNA biosynthesis|RNA formation|RNA synthesis|double-stranded RNA biosynthesis|double-stranded RNA biosynthetic process|dsRNA biosynthesis|dsRNA biosynthetic process http://purl.obolibrary.org/obo/GO_0032774 gocheck_do_not_annotate GO:0017133 biolink:CellularComponent mitochondrial electron transfer flavoprotein complex A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system. go.json http://purl.obolibrary.org/obo/GO_0017133 GO:0017136 biolink:MolecularActivity NAD-dependent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. go.json SIR2 http://purl.obolibrary.org/obo/GO_0017136 GO:0032773 biolink:BiologicalProcess positive regulation of tyrosinase activity Any process that activates or increases the activity of a tyrosinase enzyme monophenol oxygenase. go.json activation of monophenol oxygenase activity|positive regulation of monophenol monooxygenase activity|positive regulation of monophenol oxygenase activity|stimulation of monophenol oxygenase activity|up regulation of monophenol oxygenase activity|up-regulation of monophenol oxygenase activity|upregulation of monophenol oxygenase activity http://purl.obolibrary.org/obo/GO_0032773 gocheck_do_not_annotate GO:0017135 biolink:MolecularActivity obsolete membrane-associated protein with guanylate kinase activity interacting OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity. go.json membrane-associated protein with guanylate kinase activity interacting True http://purl.obolibrary.org/obo/GO_0017135 GO:0032772 biolink:BiologicalProcess negative regulation of tyrosinase activity Any process that stops or reduces the activity of a tyrosinase enzyme. go.json down regulation of monophenol oxygenase activity|down-regulation of monophenol oxygenase activity|downregulation of monophenol oxygenase activity|inhibition of monophenol oxygenase activity|negative regulation of monophenol monooxygenase activity|negative regulation of monophenol oxygenase activity http://purl.obolibrary.org/obo/GO_0032772 gocheck_do_not_annotate GO:0017130 biolink:MolecularActivity poly(C) RNA binding Binding to a sequence of cytosine residues in an RNA molecule. go.json poly(C) binding|poly(rC) binding http://purl.obolibrary.org/obo/GO_0017130 GO:0032771 biolink:BiologicalProcess regulation of tyrosinase activity Any process that modulates the activity of a tyrosinase enzyme. go.json regulation of monophenol monooxygenase activity|regulation of monophenol oxygenase activity http://purl.obolibrary.org/obo/GO_0032771 gocheck_do_not_annotate GO:0032770 biolink:BiologicalProcess positive regulation of monooxygenase activity Any process that activates or increases the activity of a monooxygenase. go.json activation of monooxygenase activity|stimulation of monooxygenase activity|up regulation of monooxygenase activity|up-regulation of monooxygenase activity|upregulation of monooxygenase activity http://purl.obolibrary.org/obo/GO_0032770 gocheck_do_not_annotate GO:0017132 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017132 GO:0017131 biolink:MolecularActivity uridine-rich cytoplasmic polyadenylylation element binding Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation. go.json U-rich CPE binding|uridine-rich cytoplasmic polyadenylation element binding http://purl.obolibrary.org/obo/GO_0017131 GO:0042150 biolink:BiologicalProcess plasmid recombination A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules. go.json http://purl.obolibrary.org/obo/GO_0042150 GO:0017150 biolink:MolecularActivity tRNA dihydrouridine synthase activity Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. Reactome:R-HSA-6782296 go.json http://purl.obolibrary.org/obo/GO_0017150 GO:0032769 biolink:BiologicalProcess negative regulation of monooxygenase activity Any process that stops or reduces the activity of a monooxygenase. go.json down regulation of monooxygenase activity|down-regulation of monooxygenase activity|downregulation of monooxygenase activity|inhibition of monooxygenase activity http://purl.obolibrary.org/obo/GO_0032769 gocheck_do_not_annotate GO:0032768 biolink:BiologicalProcess regulation of monooxygenase activity Any process that modulates the activity of a monooxygenase. go.json http://purl.obolibrary.org/obo/GO_0032768 gocheck_do_not_annotate GO:0032767 biolink:MolecularActivity copper-dependent protein binding Binding to a protein or protein complex, in the presence of copper. go.json http://purl.obolibrary.org/obo/GO_0032767 GO:0032766 biolink:CellularComponent NHE3/E3KARP/ACTN4 complex A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments. go.json NHE3/E3KARP/alpha-actinin complex http://purl.obolibrary.org/obo/GO_0032766 GO:0032765 biolink:BiologicalProcess positive regulation of mast cell cytokine production Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production. go.json activation of mast cell cytokine production|stimulation of mast cell cytokine production|up regulation of mast cell cytokine production|up-regulation of mast cell cytokine production|upregulation of mast cell cytokine production http://purl.obolibrary.org/obo/GO_0032765 GO:0042156 biolink:MolecularActivity obsolete zinc-mediated transcriptional activator activity OBSOLETE. Initiates or upregulates transcription in the presence of zinc. go.json zinc-mediated transcriptional activator activity True http://purl.obolibrary.org/obo/GO_0042156 GO:0042155 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042155 GO:0042158 biolink:BiologicalProcess lipoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. go.json lipoprotein anabolism|lipoprotein biosynthesis|lipoprotein formation|lipoprotein synthesis http://purl.obolibrary.org/obo/GO_0042158 goslim_pombe GO:0042157 biolink:BiologicalProcess lipoprotein metabolic process The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. go.json lipoprotein metabolism http://purl.obolibrary.org/obo/GO_0042157 GO:0042152 biolink:BiologicalProcess RNA-mediated DNA recombination The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele. go.json http://purl.obolibrary.org/obo/GO_0042152 GO:0042151 biolink:CellularComponent nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. Wikipedia:Cnidocyte go.json cnidocyst http://purl.obolibrary.org/obo/GO_0042151 GO:0042154 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042154 GO:0042153 biolink:MolecularActivity obsolete RPTP-like protein binding OBSOLETE. Binding to proteins with similar structure/function to receptor protein tyrosine phosphatases. go.json RPTP-like protein binding|receptor protein tyrosine phosphatase-like protein binding True http://purl.obolibrary.org/obo/GO_0042153 GO:0017149 biolink:MolecularActivity obsolete protein biosynthetic process inhibitor activity OBSOLETE. (Was not defined before being made obsolete). go.json protein anabolism inhibitor activity|protein biosynthetic process inhibitor activity|protein formation inhibitor activity|protein synthesis inhibitor activity True http://purl.obolibrary.org/obo/GO_0017149 GO:0017148 biolink:BiologicalProcess negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. go.json down regulation of protein biosynthetic process|down-regulation of protein biosynthetic process|downregulation of protein biosynthetic process|inhibition of protein biosynthetic process|negative regulation of protein anabolism|negative regulation of protein biosynthesis|negative regulation of protein biosynthetic process|negative regulation of protein formation|negative regulation of protein synthesis|protein biosynthesis inhibitor activity|protein biosynthetic process inhibitor activity http://purl.obolibrary.org/obo/GO_0017148 GO:0042159 biolink:BiologicalProcess lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. go.json lipoprotein breakdown|lipoprotein catabolism|lipoprotein degradation http://purl.obolibrary.org/obo/GO_0042159 GO:0017145 biolink:BiologicalProcess stem cell division The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. go.json stem cell renewal http://purl.obolibrary.org/obo/GO_0017145 GO:0032764 biolink:BiologicalProcess negative regulation of mast cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production. go.json down regulation of mast cell cytokine production|down-regulation of mast cell cytokine production|downregulation of mast cell cytokine production|inhibition of mast cell cytokine production http://purl.obolibrary.org/obo/GO_0032764 GO:0032763 biolink:BiologicalProcess regulation of mast cell cytokine production Any process that modulates the frequency, rate, or extent of mast cell cytokine production. go.json http://purl.obolibrary.org/obo/GO_0032763 GO:0017144 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017144 GO:0017147 biolink:MolecularActivity Wnt-protein binding Binding to a Wnt-protein, a secreted growth factor involved in signaling. go.json http://purl.obolibrary.org/obo/GO_0017147 goslim_chembl GO:0032762 biolink:BiologicalProcess mast cell cytokine production Any process that contributes to cytokine production by a mast cell. go.json http://purl.obolibrary.org/obo/GO_0032762 gocheck_do_not_annotate GO:0017146 biolink:CellularComponent NMDA selective glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. go.json N-methyl-D-aspartate selective glutamate receptor complex|NMDA-selective glutamate receptor http://purl.obolibrary.org/obo/GO_0017146 GO:0032761 biolink:BiologicalProcess positive regulation of lymphotoxin A production Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production. go.json activation of lymphotoxin A production|positive regulation of LTA production|positive regulation of TNF-beta production|positive regulation of lymphotoxin A biosynthetic process|positive regulation of lymphotoxin-alpha production|positive regulation of tumor necrosis factor-beta production|stimulation of lymphotoxin A production|up regulation of lymphotoxin A production|up-regulation of lymphotoxin A production|upregulation of lymphotoxin A production http://purl.obolibrary.org/obo/GO_0032761 GO:0032760 biolink:BiologicalProcess positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. go.json activation of tumor necrosis factor production|positive regulation of TNF production|positive regulation of TNF secretion|positive regulation of TNF-alpha production|positive regulation of cachectin secretion|positive regulation of tumor necrosis factor biosynthesis|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor formation|positive regulation of tumor necrosis factor secretion|positive regulation of tumor necrosis factor-alpha production|stimulation of tumor necrosis factor production|up regulation of tumor necrosis factor production|up-regulation of tumor necrosis factor production|upregulation of tumor necrosis factor production http://purl.obolibrary.org/obo/GO_0032760 GO:0017141 biolink:BiologicalProcess obsolete antibiotic susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json antibiotic susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0017141 GO:0017140 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017140 GO:0017143 biolink:BiologicalProcess insecticide metabolic process The chemical reactions and pathways involving insecticides, chemicals used to kill insects. go.json insecticide metabolism http://purl.obolibrary.org/obo/GO_0017143 GO:0017142 biolink:BiologicalProcess obsolete toxin susceptibility/resistance OBSOLETE. (Was not defined before being made obsolete). go.json toxin susceptibility/resistance True http://purl.obolibrary.org/obo/GO_0017142 GO:0042161 biolink:BiologicalProcess lipoprotein oxidation The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group. go.json http://purl.obolibrary.org/obo/GO_0042161 GO:0032759 biolink:BiologicalProcess positive regulation of TRAIL production Any process that activates or increases the frequency, rate, or extent of TRAIL production. go.json activation of TRAIL production|positive regulation of TRAIL biosynthetic process|stimulation of TRAIL production|up regulation of TRAIL production|up-regulation of TRAIL production|upregulation of TRAIL production http://purl.obolibrary.org/obo/GO_0032759 GO:0032758 biolink:BiologicalProcess positive regulation of interleukin-9 production Any process that activates or increases the frequency, rate, or extent of interleukin-9 production. go.json activation of interleukin-9 production|positive regulation of IL-9 production|positive regulation of interleukin-9 biosynthetic process|stimulation of interleukin-9 production|up regulation of interleukin-9 production|up-regulation of interleukin-9 production|upregulation of interleukin-9 production http://purl.obolibrary.org/obo/GO_0032758 GO:0042160 biolink:BiologicalProcess lipoprotein modification The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. go.json http://purl.obolibrary.org/obo/GO_0042160 GO:0032757 biolink:BiologicalProcess positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. go.json activation of interleukin-8 production|positive regulation of IL-8 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 secretion|stimulation of interleukin-8 production|up regulation of interleukin-8 production|up-regulation of interleukin-8 production|upregulation of interleukin-8 production http://purl.obolibrary.org/obo/GO_0032757 GO:0032756 biolink:BiologicalProcess positive regulation of interleukin-7 production Any process that activates or increases the frequency, rate, or extent of interleukin-7 production. go.json activation of interleukin-7 production|positive regulation of IL-7 production|positive regulation of interleukin-7 biosynthetic process|positive regulation of interleukin-7 secretion|stimulation of interleukin-7 production|up regulation of interleukin-7 production|up-regulation of interleukin-7 production|upregulation of interleukin-7 production http://purl.obolibrary.org/obo/GO_0032756 GO:0032755 biolink:BiologicalProcess positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. go.json activation of interleukin-6 production|positive regulation of IL-6 production|positive regulation of interleukin-6 biosynthetic process|positive regulation of interleukin-6 secretion|stimulation of interleukin-6 production|up regulation of interleukin-6 production|up-regulation of interleukin-6 production|upregulation of interleukin-6 production http://purl.obolibrary.org/obo/GO_0032755 GO:0032754 biolink:BiologicalProcess positive regulation of interleukin-5 production Any process that activates or increases the frequency, rate, or extent of interleukin-5 production. go.json activation of interleukin-5 production|positive regulation of IL-5 production|positive regulation of interleukin-5 biosynthetic process|positive regulation of interleukin-5 secretion|stimulation of interleukin-5 production|up regulation of interleukin-5 production|up-regulation of interleukin-5 production|upregulation of interleukin-5 production http://purl.obolibrary.org/obo/GO_0032754 GO:0042167 biolink:BiologicalProcess heme catabolic process The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. go.json haem catabolic process|haem catabolism|heme breakdown|heme catabolism|heme degradation http://purl.obolibrary.org/obo/GO_0042167 GO:0042166 biolink:MolecularActivity acetylcholine binding Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. go.json http://purl.obolibrary.org/obo/GO_0042166 GO:0042169 biolink:MolecularActivity SH2 domain binding Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. go.json http://purl.obolibrary.org/obo/GO_0042169 GO:0042168 biolink:BiologicalProcess heme metabolic process The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. go.json haem metabolic process|haem metabolism|heme metabolism http://purl.obolibrary.org/obo/GO_0042168 GO:0042163 biolink:MolecularActivity interleukin-12 beta subunit binding Binding to the beta subunit of interleukin-12. go.json CLMFp40 binding|IL-12B binding|IL-12p40 binding|NKSFp40 binding http://purl.obolibrary.org/obo/GO_0042163 GO:0042162 biolink:MolecularActivity telomeric DNA binding Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. go.json telomere binding|telomeric repeat binding http://purl.obolibrary.org/obo/GO_0042162 GO:0042165 biolink:MolecularActivity obsolete neurotransmitter binding OBSOLETE. Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. go.json True http://purl.obolibrary.org/obo/GO_0042165 GO:0042164 biolink:MolecularActivity interleukin-12 alpha subunit binding Binding to the alpha subunit of interleukin-12. go.json CLMFp35 binding|IL-12A binding|IL-12p35 binding|NKSFp35 binding http://purl.obolibrary.org/obo/GO_0042164 GO:0017119 biolink:CellularComponent Golgi transport complex A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. go.json COG complex|Sec34/35 complex|conserved oligomeric Golgi complex http://purl.obolibrary.org/obo/GO_0017119 GO:0017116 biolink:MolecularActivity single-stranded DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. go.json single-stranded DNA-dependent ATP-dependent DNA helicase activity|single-stranded DNA-dependent ATPase activity|ssDNA-dependent ATP-dependent DNA helicase activity|ssDNA-dependent ATPase activity http://purl.obolibrary.org/obo/GO_0017116 GO:0017115 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017115 GO:0017118 biolink:MolecularActivity lipoyltransferase activity Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+. RHEA:20473 go.json http://purl.obolibrary.org/obo/GO_0017118 GO:0017117 biolink:CellularComponent single-stranded DNA-dependent ATP-dependent DNA helicase complex A protein complex that possesses single-stranded DNA-dependent DNA helicase activity. go.json ssDNA-dependent ATP-dependent DNA helicase complex http://purl.obolibrary.org/obo/GO_0017117 GO:0032753 biolink:BiologicalProcess positive regulation of interleukin-4 production Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. go.json activation of interleukin-4 production|positive regulation of IL-4 production|positive regulation of interleukin-4 biosynthetic process|positive regulation of interleukin-4 secretion|stimulation of interleukin-4 production|up regulation of interleukin-4 production|up-regulation of interleukin-4 production|upregulation of interleukin-4 production http://purl.obolibrary.org/obo/GO_0032753 GO:0017112 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017112 GO:0017111 biolink:MolecularActivity ribonucleoside triphosphate phosphatase activity Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. EC:3.6.1.15|MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN|RHEA:23680|Reactome:R-HSA-8850846|Reactome:R-HSA-8851089|Reactome:R-HSA-8851110|Reactome:R-HSA-8851234|Reactome:R-HSA-8851494|Reactome:R-HSA-8851538 go.json NTPase activity|apyrase activity|nucleoside 5-triphosphatase activity|nucleoside triphosphatase activity|nucleoside triphosphate hydrolase activity|nucleoside triphosphate phosphatase activity|nucleoside triphosphate phosphohydrolase activity|nucleoside-5-triphosphate phosphohydrolase activity|nucleoside-triphosphatase activity http://purl.obolibrary.org/obo/GO_0017111 goslim_chembl|goslim_metagenomics GO:0032752 biolink:BiologicalProcess positive regulation of interleukin-3 production Any process that activates or increases the frequency, rate, or extent of interleukin-3 production. go.json activation of interleukin-3 production|positive regulation of IL-3 production|positive regulation of interleukin-3 biosynthetic process|stimulation of interleukin-3 production|up regulation of interleukin-3 production|up-regulation of interleukin-3 production|upregulation of interleukin-3 production http://purl.obolibrary.org/obo/GO_0032752 GO:0032751 biolink:BiologicalProcess positive regulation of interleukin-27 production Any process that activates or increases the frequency, rate, or extent of interleukin-27 production. go.json activation of interleukin-27 production|positive regulation of IL-27 production|positive regulation of interleukin-27 anabolism|positive regulation of interleukin-27 biosynthetic process|stimulation of interleukin-27 production|up regulation of interleukin-27 production|up-regulation of interleukin-27 production|upregulation of interleukin-27 production http://purl.obolibrary.org/obo/GO_0032751 GO:0017114 biolink:MolecularActivity obsolete wide-spectrum protease inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease. go.json wide-spectrum protease inhibitor activity|wide-spectrum proteinase inhibitor True http://purl.obolibrary.org/obo/GO_0017114 GO:0017113 biolink:MolecularActivity dihydropyrimidine dehydrogenase (NADP+) activity Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. EC:1.3.1.2|MetaCyc:1.3.1.2-RXN|RHEA:18093|Reactome:R-HSA-73585|Reactome:R-HSA-73616 go.json 4,5-dihydrothymine: oxidoreductase activity|5,6-dihydrouracil:NADP+ 5-oxidoreductase activity|DHPDH|DHU dehydrogenase activity|DPD|dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)|dihydropyrimidine dehydrogenase activity|dihydrothymine dehydrogenase activity|dihydrouracil dehydrogenase (NADP)|dihydrouracil dehydrogenase (NADP+) activity|hydropyrimidine dehydrogenase activity http://purl.obolibrary.org/obo/GO_0017113 GO:0032750 biolink:BiologicalProcess positive regulation of interleukin-26 production Any process that activates or increases the frequency, rate, or extent of interleukin-26 production. go.json activation of interleukin-26 production|positive regulation of IL-26 production|positive regulation of interleukin-26 biosynthetic process|stimulation of interleukin-26 production|up regulation of interleukin-26 production|up-regulation of interleukin-26 production|upregulation of interleukin-26 production http://purl.obolibrary.org/obo/GO_0032750 GO:0017110 biolink:MolecularActivity nucleoside diphosphate phosphatase activity Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. EC:3.6.1.6|MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN|RHEA:36799|Reactome:R-HSA-8850854|Reactome:R-HSA-8851129|Reactome:R-HSA-8851225|Reactome:R-HSA-8851356|Reactome:R-HSA-8851396|Reactome:R-HSA-8851550 go.json NDPase activity|apyrase activity|inosine 5'-diphosphatase|inosine diphosphatase|nucleoside 5'-diphosphatase activity|nucleoside diphosphatase activity|nucleoside diphosphate phosphohydrolase activity|nucleoside-diphosphatase activity|nucleoside-diphosphate phosphohydrolase activity|type B nucleoside diphosphatase|type L nucleoside diphosphatase http://purl.obolibrary.org/obo/GO_0017110 GO:0042170 biolink:CellularComponent plastid membrane Either of the lipid bilayers that surround a plastid and form the plastid envelope. go.json http://purl.obolibrary.org/obo/GO_0042170 GO:0032749 biolink:BiologicalProcess positive regulation of interleukin-25 production Any process that activates or increases the frequency, rate, or extent of interleukin-25 production. go.json activation of interleukin-25 production|positive regulation of IL-25 production|positive regulation of interleukin-25 biosynthetic process|positive regulation of interleukin-25 secretion|stimulation of interleukin-25 production|up regulation of interleukin-25 production|up-regulation of interleukin-25 production|upregulation of interleukin-25 production http://purl.obolibrary.org/obo/GO_0032749 GO:0032748 biolink:BiologicalProcess positive regulation of interleukin-24 production Any process that activates or increases the frequency, rate, or extent of interleukin-24 production. go.json activation of interleukin-24 production|positive regulation of IL-24 production|positive regulation of interleukin-24 biosynthetic process|stimulation of interleukin-24 production|up regulation of interleukin-24 production|up-regulation of interleukin-24 production|upregulation of interleukin-24 production http://purl.obolibrary.org/obo/GO_0032748 GO:0042172 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042172 GO:0032747 biolink:BiologicalProcess positive regulation of interleukin-23 production Any process that activates or increases the frequency, rate, or extent of interleukin-23 production. go.json activation of interleukin-23 production|positive regulation of IL-23 production|positive regulation of interleukin-23 biosynthetic process|stimulation of interleukin-23 production|up regulation of interleukin-23 production|up-regulation of interleukin-23 production|upregulation of interleukin-23 production http://purl.obolibrary.org/obo/GO_0032747 GO:0042171 biolink:MolecularActivity lysophosphatidic acid acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. go.json LPAAT activity http://purl.obolibrary.org/obo/GO_0042171 GO:0032746 biolink:BiologicalProcess positive regulation of interleukin-22 production Any process that activates or increases the frequency, rate, or extent of interleukin-22 production. go.json activation of interleukin-22 production|positive regulation of IL-22 production|positive regulation of interleukin-22 biosynthetic process|stimulation of interleukin-22 production|up regulation of interleukin-22 production|up-regulation of interleukin-22 production|upregulation of interleukin-22 production http://purl.obolibrary.org/obo/GO_0032746 GO:0032745 biolink:BiologicalProcess positive regulation of interleukin-21 production Any process that activates or increases the frequency, rate, or extent of interleukin-21 production. go.json activation of interleukin-21 production|positive regulation of IL-21 production|positive regulation of interleukin-21 biosynthetic process|stimulation of interleukin-21 production|up regulation of interleukin-21 production|up-regulation of interleukin-21 production|upregulation of interleukin-21 production http://purl.obolibrary.org/obo/GO_0032745 GO:0032744 biolink:BiologicalProcess positive regulation of interleukin-20 production Any process that activates or increases the frequency, rate, or extent of interleukin-20 production. go.json activation of interleukin-20 production|positive regulation of IL-20 production|positive regulation of interleukin-20 biosynthetic process|stimulation of interleukin-20 production|up regulation of interleukin-20 production|up-regulation of interleukin-20 production|upregulation of interleukin-20 production http://purl.obolibrary.org/obo/GO_0032744 GO:0032743 biolink:BiologicalProcess positive regulation of interleukin-2 production Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. go.json activation of interleukin-2 production|positive regulation of IL-2 production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-2 secretion|stimulation of interleukin-2 production|up regulation of interleukin-2 production|up-regulation of interleukin-2 production|upregulation of interleukin-2 production http://purl.obolibrary.org/obo/GO_0032743 GO:0042178 biolink:BiologicalProcess xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json drug breakdown|drug catabolic process|drug catabolism|drug degradation|exogenous drug breakdown|exogenous drug catabolic process|exogenous drug catabolism|exogenous drug degradation|xenobiotic breakdown|xenobiotic catabolism|xenobiotic degradation http://purl.obolibrary.org/obo/GO_0042178 prokaryote_subset GO:0042177 biolink:BiologicalProcess negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. go.json down regulation of cellular protein breakdown|down regulation of cellular protein catabolic process|down regulation of cellular protein catabolism|down regulation of cellular protein degradation|down regulation of protein catabolic process|down-regulation of cellular protein breakdown|down-regulation of cellular protein catabolic process|down-regulation of cellular protein catabolism|down-regulation of cellular protein degradation|down-regulation of protein catabolic process|downregulation of cellular protein breakdown|downregulation of cellular protein catabolic process|downregulation of cellular protein catabolism|downregulation of cellular protein degradation|downregulation of protein catabolic process|inhibition of cellular protein breakdown|inhibition of cellular protein catabolic process|inhibition of cellular protein catabolism|inhibition of cellular protein degradation|inhibition of protein catabolic process|negative regulation of cellular protein breakdown|negative regulation of cellular protein catabolic process|negative regulation of cellular protein catabolism|negative regulation of cellular protein degradation|negative regulation of protein breakdown|negative regulation of protein catabolism|negative regulation of protein degradation http://purl.obolibrary.org/obo/GO_0042177 GO:0042179 biolink:BiologicalProcess nicotine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. go.json nicotine anabolism|nicotine biosynthesis|nicotine formation|nicotine synthesis http://purl.obolibrary.org/obo/GO_0042179 GO:0042174 biolink:BiologicalProcess negative regulation of sporulation resulting in formation of a cellular spore Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation. go.json down regulation of sporulation|down-regulation of sporulation|downregulation of sporulation|inhibition of sporulation http://purl.obolibrary.org/obo/GO_0042174 GO:0042173 biolink:BiologicalProcess regulation of sporulation resulting in formation of a cellular spore Any process that modulates the frequency, rate or extent of spore formation. go.json http://purl.obolibrary.org/obo/GO_0042173 GO:0042176 biolink:BiologicalProcess regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. go.json regulation of cellular protein breakdown|regulation of cellular protein catabolic process|regulation of cellular protein catabolism|regulation of cellular protein degradation|regulation of cyclin breakdown|regulation of cyclin catabolic process|regulation of cyclin catabolism|regulation of cyclin degradation|regulation of degradation of cyclin|regulation of protein breakdown|regulation of protein catabolism|regulation of protein degradation http://purl.obolibrary.org/obo/GO_0042176 GO:0042175 biolink:CellularComponent nuclear outer membrane-endoplasmic reticulum membrane network The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. go.json NE-ER continuum|NE-ER network|nuclear envelope-ER network|nuclear envelope-endoplasmic reticulum continuum|nuclear envelope-endoplasmic reticulum network|nuclear membrane-ER network|nuclear membrane-endoplasmic reticulum continuum http://purl.obolibrary.org/obo/GO_0042175 GO:0017127 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017127 GO:0017126 biolink:BiologicalProcess nucleologenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. go.json nucleolus assembly|nucleolus biogenesis http://purl.obolibrary.org/obo/GO_0017126 GO:0017129 biolink:MolecularActivity triglyceride binding Binding to a triester of glycerol. go.json triacylglycerol binding http://purl.obolibrary.org/obo/GO_0017129 GO:0017128 biolink:MolecularActivity phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. go.json http://purl.obolibrary.org/obo/GO_0017128 GO:0017123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017123 GO:0032742 biolink:BiologicalProcess positive regulation of interleukin-19 production Any process that activates or increases the frequency, rate, or extent of interleukin-19 production. go.json activation of interleukin-19 production|positive regulation of IL-19 production|positive regulation of interleukin-19 biosynthetic process|stimulation of interleukin-19 production|up regulation of interleukin-19 production|up-regulation of interleukin-19 production|upregulation of interleukin-19 production http://purl.obolibrary.org/obo/GO_0032742 GO:0017122 biolink:CellularComponent protein N-acetylglucosaminyltransferase complex A protein complex capable of protein N-acetylglucosaminyltransferase activity, the addition of nucleotide-activated sugars onto the polypeptide according to reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. The complex has different compositions in different species: In mammals it is often a homotrimer, in bacteria a heterotetramer of 2 different subunits. go.json O-GlcNAc transferase complex|UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase http://purl.obolibrary.org/obo/GO_0017122 GO:0032741 biolink:BiologicalProcess positive regulation of interleukin-18 production Any process that activates or increases the frequency, rate, or extent of interleukin-18 production. go.json activation of interleukin-18 production|positive regulation of IL-18 production|positive regulation of interleukin-18 biosynthetic process|positive regulation of interleukin-18 secretion|stimulation of interleukin-18 production|up regulation of interleukin-18 production|up-regulation of interleukin-18 production|upregulation of interleukin-18 production http://purl.obolibrary.org/obo/GO_0032741 GO:0017125 biolink:MolecularActivity deoxycytidyl transferase activity Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA. Reactome:R-HSA-110308 go.json deoxycytidyl transferase activity, template-dependent http://purl.obolibrary.org/obo/GO_0017125 GO:0032740 biolink:BiologicalProcess positive regulation of interleukin-17 production Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. go.json activation of interleukin-17 production|positive regulation of CTLA-8 production|positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production|positive regulation of IL-17 production|positive regulation of interleukin-17 biosynthetic process|positive regulation of interleukin-17 secretion|stimulation of interleukin-17 production|up regulation of interleukin-17 production|up-regulation of interleukin-17 production|upregulation of interleukin-17 production http://purl.obolibrary.org/obo/GO_0032740 GO:0017124 biolink:MolecularActivity SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. go.json http://purl.obolibrary.org/obo/GO_0017124 GO:0017121 biolink:BiologicalProcess plasma membrane phospholipid scrambling The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). go.json PL scrambling|phospholipid scrambling http://purl.obolibrary.org/obo/GO_0017121 GO:0017120 biolink:MolecularActivity obsolete polyphosphatidylinositol phosphatase activity OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization. go.json polyphosphatidylinositol phosphatase activity|polyphosphoinositide phosphatase activity True http://purl.obolibrary.org/obo/GO_0017120 GO:0042181 biolink:BiologicalProcess ketone biosynthetic process The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. go.json ketone anabolism|ketone biosynthesis|ketone formation|ketone synthesis http://purl.obolibrary.org/obo/GO_0042181 GO:0032739 biolink:BiologicalProcess positive regulation of interleukin-16 production Any process that activates or increases the frequency, rate, or extent of interleukin-16 production. go.json activation of interleukin-16 production|positive regulation of IL-16 production|positive regulation of interleukin-16 biosynthetic process|stimulation of interleukin-16 production|up regulation of interleukin-16 production|up-regulation of interleukin-16 production|upregulation of interleukin-16 production http://purl.obolibrary.org/obo/GO_0032739 GO:0032738 biolink:BiologicalProcess positive regulation of interleukin-15 production Any process that activates or increases the frequency, rate, or extent of interleukin-15 production. go.json activation of interleukin-15 production|positive regulation of IL-15 production|positive regulation of interleukin-15 biosynthetic process|stimulation of interleukin-15 production|up regulation of interleukin-15 production|up-regulation of interleukin-15 production|upregulation of interleukin-15 production http://purl.obolibrary.org/obo/GO_0032738 GO:0042180 biolink:BiologicalProcess cellular ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. go.json ketone metabolism http://purl.obolibrary.org/obo/GO_0042180 goslim_pir GO:0032737 biolink:BiologicalProcess obsolete positive regulation of interleukin-14 production OBSOLETE. Any process that activates or increases the frequency, rate, or extent of interleukin-14 production. go.json activation of interleukin-14 production|positive regulation of IL-14 production|positive regulation of interleukin-14 biosynthetic process|stimulation of interleukin-14 production|up regulation of interleukin-14 production|up-regulation of interleukin-14 production|upregulation of interleukin-14 production True http://purl.obolibrary.org/obo/GO_0032737 GO:0042183 biolink:BiologicalProcess formate catabolic process The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. go.json formate breakdown|formate catabolism|formate degradation|formic acid catabolic process|formic acid catabolism http://purl.obolibrary.org/obo/GO_0042183 GO:0032736 biolink:BiologicalProcess positive regulation of interleukin-13 production Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. go.json activation of interleukin-13 production|positive regulation of IL-13 production|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-13 secretion|stimulation of interleukin-13 production|up regulation of interleukin-13 production|up-regulation of interleukin-13 production|upregulation of interleukin-13 production http://purl.obolibrary.org/obo/GO_0032736 GO:0042182 biolink:BiologicalProcess ketone catabolic process The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. go.json ketone breakdown|ketone catabolism|ketone degradation http://purl.obolibrary.org/obo/GO_0042182 GO:0032735 biolink:BiologicalProcess positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. go.json activation of interleukin-12 production|positive regulation of CLMF production|positive regulation of IL-12 production|positive regulation of NKSF production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 secretion|stimulation of interleukin-12 production|up regulation of interleukin-12 production|up-regulation of interleukin-12 production|upregulation of interleukin-12 production http://purl.obolibrary.org/obo/GO_0032735 GO:0032734 biolink:BiologicalProcess positive regulation of interleukin-11 production Any process that activates or increases the frequency, rate, or extent of interleukin-11 production. go.json activation of interleukin-11 production|positive regulation of IL-11 production|positive regulation of interleukin-11 biosynthetic process|positive regulation of interleukin-11 secretion|stimulation of interleukin-11 production|up regulation of interleukin-11 production|up-regulation of interleukin-11 production|upregulation of interleukin-11 production http://purl.obolibrary.org/obo/GO_0032734 GO:0032733 biolink:BiologicalProcess positive regulation of interleukin-10 production Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. go.json activation of interleukin-10 production|positive regulation of IL-10 production|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-10 secretion|stimulation of interleukin-10 production|up regulation of interleukin-10 production|up-regulation of interleukin-10 production|upregulation of interleukin-10 production http://purl.obolibrary.org/obo/GO_0032733 GO:0032732 biolink:BiologicalProcess positive regulation of interleukin-1 production Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. go.json activation of interleukin-1 production|positive regulation of IL-1 production|positive regulation of interleukin-1 biosynthetic process|positive regulation of interleukin-1 secretion|stimulation of interleukin-1 production|up regulation of interleukin-1 production|up-regulation of interleukin-1 production|upregulation of interleukin-1 production http://purl.obolibrary.org/obo/GO_0032732 GO:0042189 biolink:BiologicalProcess vanillin biosynthetic process The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods. go.json vanillic aldehyde biosynthesis|vanillic aldehyde biosynthetic process|vanillin anabolism|vanillin biosynthesis|vanillin formation|vanillin synthesis http://purl.obolibrary.org/obo/GO_0042189 GO:0042188 biolink:BiologicalProcess 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. go.json 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown|1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism|1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation|DDT catabolic process|DDT catabolism http://purl.obolibrary.org/obo/GO_0042188 GO:0042185 biolink:BiologicalProcess m-xylene catabolic process The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon. MetaCyc:PWY-142 go.json m-xylene breakdown|m-xylene catabolism|m-xylene degradation|meta-xylene catabolic process|meta-xylene catabolism http://purl.obolibrary.org/obo/GO_0042185 GO:0042184 biolink:BiologicalProcess xylene catabolic process The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. go.json xylene breakdown|xylene catabolism|xylene degradation http://purl.obolibrary.org/obo/GO_0042184 GO:0042187 biolink:BiologicalProcess p-xylene catabolic process The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon. go.json p-xylene breakdown|p-xylene catabolism|p-xylene degradation|para-xylene catabolic process|para-xylene catabolism http://purl.obolibrary.org/obo/GO_0042187 GO:0042186 biolink:BiologicalProcess o-xylene catabolic process The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. go.json o-xylene breakdown|o-xylene catabolism|o-xylene degradation|ortho-xylene catabolic process|ortho-xylene catabolism http://purl.obolibrary.org/obo/GO_0042186 GO:0032731 biolink:BiologicalProcess positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. go.json activation of interleukin-1 beta production|positive regulation of IL-1 beta production|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of interleukin-1 beta secretion|stimulation of interleukin-1 beta production|up regulation of interleukin-1 beta production|up-regulation of interleukin-1 beta production|upregulation of interleukin-1 beta production http://purl.obolibrary.org/obo/GO_0032731 GO:0032730 biolink:BiologicalProcess positive regulation of interleukin-1 alpha production Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production. go.json activation of interleukin-1 alpha production|positive regulation of IL-1 alpha production|positive regulation of interleukin-1 alpha biosynthetic process|positive regulation of interleukin-1 alpha secretion|stimulation of interleukin-1 alpha production|up regulation of interleukin-1 alpha production|up-regulation of interleukin-1 alpha production|upregulation of interleukin-1 alpha production http://purl.obolibrary.org/obo/GO_0032730 GO:0032728 biolink:BiologicalProcess positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production. go.json activation of interferon-beta production|positive regulation of IFN-beta production|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta secretion|stimulation of interferon-beta production|up regulation of interferon-beta production|up-regulation of interferon-beta production|upregulation of interferon-beta production http://purl.obolibrary.org/obo/GO_0032728 GO:0042192 biolink:BiologicalProcess methylmercury biosynthetic process The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal. go.json methylmercury anabolism|methylmercury biosynthesis|methylmercury formation|methylmercury synthesis http://purl.obolibrary.org/obo/GO_0042192 GO:0032727 biolink:BiologicalProcess positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. go.json activation of interferon-alpha production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-alpha secretion|stimulation of interferon-alpha production|up regulation of interferon-alpha production|up-regulation of interferon-alpha production|upregulation of interferon-alpha production http://purl.obolibrary.org/obo/GO_0032727 GO:0042191 biolink:BiologicalProcess methylmercury metabolic process The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species. go.json methylmercury metabolism http://purl.obolibrary.org/obo/GO_0042191 GO:0032726 biolink:BiologicalProcess positive regulation of hepatocyte growth factor production Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production. go.json activation of hepatocyte growth factor production|positive regulation of HGF production|positive regulation of hepatocyte growth factor biosynthetic process|positive regulation of scatter factor production|stimulation of hepatocyte growth factor production|up regulation of hepatocyte growth factor production|up-regulation of hepatocyte growth factor production|upregulation of hepatocyte growth factor production http://purl.obolibrary.org/obo/GO_0032726 GO:0042194 biolink:BiologicalProcess quinate biosynthetic process The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid. go.json quinate anabolism|quinate biosynthesis|quinate formation|quinate synthesis|quinic acid biosynthesis|quinic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0042194 GO:0032725 biolink:BiologicalProcess positive regulation of granulocyte macrophage colony-stimulating factor production Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. go.json activation of granulocyte macrophage colony-stimulating factor production|positive regulation of GM-CSF production|positive regulation of granulocyte macrophage colony stimulating factor production|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|stimulation of granulocyte macrophage colony-stimulating factor production|up regulation of granulocyte macrophage colony-stimulating factor production|up-regulation of granulocyte macrophage colony-stimulating factor production|upregulation of granulocyte macrophage colony-stimulating factor production http://purl.obolibrary.org/obo/GO_0032725 GO:0042193 biolink:BiologicalProcess methylmercury catabolic process The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal. go.json methylmercury breakdown|methylmercury catabolism|methylmercury degradation http://purl.obolibrary.org/obo/GO_0042193 GO:0032724 biolink:BiologicalProcess positive regulation of fractalkine production Any process that activates or increases the frequency, rate, or extent of fractalkine production. go.json activation of fractalkine production|stimulation of fractalkine production|up regulation of fractalkine production|up-regulation of fractalkine production|upregulation of fractalkine production http://purl.obolibrary.org/obo/GO_0032724 GO:0032723 biolink:BiologicalProcess positive regulation of connective tissue growth factor production Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production. go.json activation of connective tissue growth factor production|positive regulation of CCN2 production|positive regulation of CTGF production|positive regulation of Fisp12 production|positive regulation of Hcs24 production|positive regulation of IGFBP8 production|positive regulation of connective tissue growth factor biosynthetic process|positive regulation of hypertrophic chondrocyte-specific gene product 24 production|stimulation of connective tissue growth factor production|up regulation of connective tissue growth factor production|up-regulation of connective tissue growth factor production|upregulation of connective tissue growth factor production http://purl.obolibrary.org/obo/GO_0032723 GO:0032722 biolink:BiologicalProcess positive regulation of chemokine production Any process that activates or increases the frequency, rate, or extent of chemokine production. go.json activation of chemokine production|positive regulation of chemokine biosynthetic process|positive regulation of chemokine secretion|stimulation of chemokine production|up regulation of chemokine production|up-regulation of chemokine production|upregulation of chemokine production http://purl.obolibrary.org/obo/GO_0032722 GO:0042190 biolink:BiologicalProcess vanillin catabolic process The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods. go.json vanillic aldehyde catabolic process|vanillic aldehyde catabolism|vanillin breakdown|vanillin catabolism|vanillin degradation http://purl.obolibrary.org/obo/GO_0042190 GO:0032721 biolink:BiologicalProcess negative regulation of lymphotoxin A production Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production. go.json down regulation of lymphotoxin A production|down-regulation of lymphotoxin A production|downregulation of lymphotoxin A production|inhibition of lymphotoxin A production|negative regulation of LTA production|negative regulation of TNF-beta production|negative regulation of lymphotoxin A biosynthetic process|negative regulation of lymphotoxin-alpha production|negative regulation of tumor necrosis factor-beta production http://purl.obolibrary.org/obo/GO_0032721 GO:0042199 biolink:BiologicalProcess cyanuric acid metabolic process The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives. go.json cyanuric acid metabolism http://purl.obolibrary.org/obo/GO_0042199 GO:0042196 biolink:BiologicalProcess chlorinated hydrocarbon metabolic process The chemical reactions and pathways involving chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms. go.json chlorinated hydrocarbon metabolism http://purl.obolibrary.org/obo/GO_0042196 GO:0042195 biolink:BiologicalProcess aerobic gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen. go.json aerobic gallate breakdown|aerobic gallate catabolism|aerobic gallate degradation|aerobic gallic acid catabolic process|aerobic gallic acid catabolism http://purl.obolibrary.org/obo/GO_0042195 GO:0042198 biolink:BiologicalProcess nylon metabolic process The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. go.json nylon metabolism http://purl.obolibrary.org/obo/GO_0042198 GO:0032729 biolink:BiologicalProcess positive regulation of type II interferon production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. go.json activation of interferon-gamma production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interferon-gamma secretion|stimulation of interferon-gamma production|up regulation of interferon-gamma production|up-regulation of interferon-gamma production|upregulation of interferon-gamma production http://purl.obolibrary.org/obo/GO_0032729 GO:0042197 biolink:BiologicalProcess halogenated hydrocarbon metabolic process The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine. go.json halogenated hydrocarbon metabolism http://purl.obolibrary.org/obo/GO_0042197 GO:0017109 biolink:CellularComponent glutamate-cysteine ligase complex An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. go.json gamma-glutamylcysteine synthetase complex http://purl.obolibrary.org/obo/GO_0017109 GO:0017108 biolink:MolecularActivity 5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Reactome:R-HSA-110363|Reactome:R-HSA-174441|Reactome:R-HSA-174446|Reactome:R-HSA-5651782|Reactome:R-HSA-5687664|Reactome:R-HSA-69152 go.json 5' flap endonuclease activity http://purl.obolibrary.org/obo/GO_0017108 GO:0017105 biolink:MolecularActivity acyl-CoA delta11-(Z)-desaturase activity Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. EC:1.14.19.5|MetaCyc:1.14.99.32-RXN|RHEA:25852 go.json Z/E11-desaturase|acyl-CoA D11-desaturase activity|acyl-CoA delta(11)-desaturase activity|acyl-CoA delta11-desaturase activity|delta(11) desaturase|delta(11)-fatty-acid desaturase|delta(11)-palmitoyl-CoA desaturase|fatty acid delta(11)-desaturase|myristoyl-CoA 11-(Z) desaturase activity http://purl.obolibrary.org/obo/GO_0017105 GO:0017104 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017104 GO:0017107 biolink:MolecularActivity obsolete anion exchanger adaptor activity OBSOLETE. The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way. go.json True http://purl.obolibrary.org/obo/GO_0017107 GO:0017106 biolink:MolecularActivity obsolete activin inhibitor activity OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone. go.json activin inhibitor activity True http://purl.obolibrary.org/obo/GO_0017106 GO:0032720 biolink:BiologicalProcess negative regulation of tumor necrosis factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. go.json down regulation of tumor necrosis factor production|down-regulation of tumor necrosis factor production|downregulation of tumor necrosis factor production|inhibition of cachectin production|inhibition of tumor necrosis factor production|negative regulation TNF production|negative regulation TNF-alpha production|negative regulation of tumor necrosis factor biosynthetic process|negative regulation of tumor necrosis factor secretion|negative regulation tumor necrosis factor-alpha production http://purl.obolibrary.org/obo/GO_0032720 GO:0017101 biolink:CellularComponent aminoacyl-tRNA synthetase multienzyme complex A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. go.json aminoacyl-tRNA synthetase complex|multisynthetase complex http://purl.obolibrary.org/obo/GO_0017101 GO:0017100 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017100 GO:0017103 biolink:MolecularActivity UTP:galactose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose. EC:2.7.7.10|KEGG_REACTION:R00502|MetaCyc:UTPHEXPURIDYLYLTRANS-RXN|RHEA:14209 go.json Gal-1-P uridylyltransferase activity|UDPgalactose pyrophosphorylase activity|UTP-hexose-1-phosphate uridylyltransferase activity|UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity|UTP:hexose-1-phosphate uridylyltransferase activity|alpha-D-galactose 1-phosphate uridylyltransferase activity|galactose 1-phosphate uridyltransferase activity|galactose 1-phosphate uridylyltransferase activity|galactose-1-phosphate uridylyltransferase activity|uridine diphosphate galactose pyrophosphorylase activity|uridine diphosphogalactose pyrophosphorylase activity http://purl.obolibrary.org/obo/GO_0017103 GO:0017102 biolink:CellularComponent methionyl glutamyl tRNA synthetase complex A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers. go.json http://purl.obolibrary.org/obo/GO_0017102 GO:0140409 biolink:BiologicalProcess positive regulation of mRNA alternative polyadenylation Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation. go.json http://purl.obolibrary.org/obo/GO_0140409 GO:0140408 biolink:BiologicalProcess regulation of mRNA alternative polyadenylation Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation. go.json http://purl.obolibrary.org/obo/GO_0140408 GO:0140403 biolink:BiologicalProcess effector-mediated suppression of host innate immune response A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json effector dependent suppression of host immune innate response by symbiont|effector triggered suppression of host immune innate response by symbiont|effector-dependent suppression of host immune innate response by symbiont|effector-mediated suppression of host immune innate response by symbiont|effector-mediated suppression of host innate immune response by symbiont|effector-mediated suppression of host innate immunity|effector-triggered suppression of host immune innate response by symbiont http://purl.obolibrary.org/obo/GO_0140403 GO:0140405 biolink:BiologicalProcess spindle pole body-led chromosome movement during mitotic interphase A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase. go.json http://purl.obolibrary.org/obo/GO_0140405 GO:0140404 biolink:BiologicalProcess effector-mediated perturbation of host innate immune response by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json effector mediated modulation of host immune response by symbiont|effector triggered modulation of host immune response by symbiont|effector-dependent modulation of host immune response by symbiont|effector-mediated modulation of host immunity|effector-mediated modulation of host innate immune response by symbiont|effector-triggered modulation of host immune response by symbiont http://purl.obolibrary.org/obo/GO_0140404 GO:0140407 biolink:MolecularActivity L-alanine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out). go.json http://purl.obolibrary.org/obo/GO_0140407 GO:0140406 biolink:BiologicalProcess L-alanine export across the plasma membrane The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region. go.json http://purl.obolibrary.org/obo/GO_0140406 GO:0017199 biolink:BiologicalProcess N-terminal peptidyl-threonine acetylation The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase. RESID:AA0052 go.json http://purl.obolibrary.org/obo/GO_0017199 gocheck_do_not_annotate GO:0017196 biolink:BiologicalProcess N-terminal peptidyl-methionine acetylation The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. RESID:AA0049 go.json http://purl.obolibrary.org/obo/GO_0017196 gocheck_do_not_annotate GO:0017195 biolink:BiologicalProcess N-terminal peptidyl-lysine N2-acetylation The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed. RESID:AA0048 go.json http://purl.obolibrary.org/obo/GO_0017195 gocheck_do_not_annotate GO:0017198 biolink:BiologicalProcess N-terminal peptidyl-serine acetylation The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine. RESID:AA0051 go.json http://purl.obolibrary.org/obo/GO_0017198 gocheck_do_not_annotate GO:0017197 biolink:BiologicalProcess N-terminal peptidyl-proline acetylation The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline. RESID:AA0050 go.json http://purl.obolibrary.org/obo/GO_0017197 gocheck_do_not_annotate GO:0017181 biolink:BiologicalProcess obsolete peptidyl-diphthine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue. go.json peptidyl-diphthine breakdown|peptidyl-diphthine catabolism|peptidyl-diphthine degradation True http://purl.obolibrary.org/obo/GO_0017181 GO:0017180 biolink:BiologicalProcess obsolete protein histidyl modification to diphthine OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine. go.json peptidyl-diphthine anabolism from peptidyl-histidine|peptidyl-diphthine biosynthetic process from peptidyl-histidine|peptidyl-diphthine formation from peptidyl-histidine|peptidyl-diphthine synthesis from peptidyl-histidine True http://purl.obolibrary.org/obo/GO_0017180 GO:0017183 biolink:BiologicalProcess protein histidyl modification to diphthamide The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria. RESID:AA0040 go.json peptidyl-diphthamide anabolism from peptidyl-histidine|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|peptidyl-diphthamide formation from peptidyl-histidine|peptidyl-diphthamide synthesis from peptidyl-histidine http://purl.obolibrary.org/obo/GO_0017183 GO:0017182 biolink:BiologicalProcess obsolete peptidyl-diphthamide metabolic process OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue. go.json peptidyl-diphthamide metabolism True http://purl.obolibrary.org/obo/GO_0017182 GO:0042101 biolink:CellularComponent T cell receptor complex A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. Wikipedia:T_cell_receptor go.json T lymphocyte receptor complex|T-cell receptor complex|T-lymphocyte receptor complex|TCR|TCR complex http://purl.obolibrary.org/obo/GO_0042101 GO:0042100 biolink:BiologicalProcess B cell proliferation The expansion of a B cell population by cell division. Follows B cell activation. go.json B lymphocyte proliferation|B-cell proliferation|B-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0042100 GO:0042103 biolink:BiologicalProcess positive regulation of T cell homeostatic proliferation Any process that activates or increases the rate or extent of resting T cell proliferation. go.json activation of T cell homeostatic proliferation|positive regulation of T lymphocyte homeostatic proliferation|positive regulation of T-cell homeostatic proliferation|positive regulation of T-lymphocyte homeostatic proliferation|positive regulation of resting T cell proliferation|stimulation of T cell homeostatic proliferation|up regulation of T cell homeostatic proliferation|up-regulation of T cell homeostatic proliferation|upregulation of T cell homeostatic proliferation http://purl.obolibrary.org/obo/GO_0042103 GO:0042102 biolink:BiologicalProcess positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation. go.json activation of T cell proliferation|positive regulation of T lymphocyte proliferation|positive regulation of T-lymphocyte proliferation|stimulation of T cell proliferation|up regulation of T cell proliferation|up-regulation of T cell proliferation|upregulation of T cell proliferation http://purl.obolibrary.org/obo/GO_0042102 GO:0042109 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042109 GO:0042108 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042108 GO:0042105 biolink:CellularComponent alpha-beta T cell receptor complex A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein. go.json alpha-beta T lymphocyte receptor complex|alpha-beta T-cell receptor complex|alpha-beta T-lymphocyte receptor complex|alpha-beta TCR complex http://purl.obolibrary.org/obo/GO_0042105 GO:0042104 biolink:BiologicalProcess positive regulation of activated T cell proliferation Any process that activates or increases the rate or extent of activated T cell proliferation. go.json activation of activated T cell proliferation|positive regulation of activated T lymphocyte proliferation|positive regulation of activated T-cell proliferation|positive regulation of activated T-lymphocyte proliferation|stimulation of activated T cell proliferation|up regulation of activated T cell proliferation|up-regulation of activated T cell proliferation|upregulation of activated T cell proliferation http://purl.obolibrary.org/obo/GO_0042104 GO:0042107 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042107 GO:0042106 biolink:CellularComponent gamma-delta T cell receptor complex A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein. go.json gamma-delta T lymphocyte receptor complex|gamma-delta T-cell receptor complex|gamma-delta T-lymphocyte receptor complex|gamma-delta TCR complex http://purl.obolibrary.org/obo/GO_0042106 GO:0017178 biolink:MolecularActivity diphthine-ammonia ligase activity Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate. EC:6.3.1.14|KEGG_REACTION:R03613|MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN|RHEA:19753|Reactome:R-HSA-5358475 go.json diphthamide synthase activity|diphthamide synthetase activity|diphthine:ammonia ligase (ADP-forming) http://purl.obolibrary.org/obo/GO_0017178 GO:0017177 biolink:CellularComponent glucosidase II complex A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins. go.json alpha-glucosidase II complex http://purl.obolibrary.org/obo/GO_0017177 GO:0017179 biolink:BiologicalProcess obsolete peptidyl-diphthine metabolic process OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue. go.json peptidyl-diphthine metabolism True http://purl.obolibrary.org/obo/GO_0017179 GO:0017174 biolink:MolecularActivity glycine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. EC:2.1.1.20|KEGG_REACTION:R00367|MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN|RHEA:19937|Reactome:R-HSA-6798317 go.json GNMT|S-adenosyl-L-methionine:glycine N-methyltransferase activity|S-adenosyl-L-methionine:glycine methyltransferase activity|glycine methyltransferase activity http://purl.obolibrary.org/obo/GO_0017174 GO:0017173 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017173 GO:0017176 biolink:MolecularActivity phosphatidylinositol N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. EC:2.4.1.198|MetaCyc:2.4.1.198-RXN|RHEA:14789 go.json UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity|UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0017176 GO:0017175 biolink:MolecularActivity obsolete IMP-GMP specific 5'-nucleotidase activity OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile. go.json IMP-GMP specific 5'-nucleotidase activity True http://purl.obolibrary.org/obo/GO_0017175 GO:0017192 biolink:BiologicalProcess N-terminal peptidyl-glutamine acetylation The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable. RESID:AA0045 go.json http://purl.obolibrary.org/obo/GO_0017192 gocheck_do_not_annotate GO:0017191 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0017191 GO:0017194 biolink:BiologicalProcess N-terminal peptidyl-isoleucine acetylation The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed. RESID:AA0047 go.json http://purl.obolibrary.org/obo/GO_0017194 gocheck_do_not_annotate GO:0017193 biolink:BiologicalProcess N-terminal peptidyl-glycine acetylation The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine. RESID:AA0046 go.json http://purl.obolibrary.org/obo/GO_0017193 gocheck_do_not_annotate GO:0017190 biolink:BiologicalProcess N-terminal peptidyl-aspartic acid acetylation The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase. RESID:AA0042 go.json http://purl.obolibrary.org/obo/GO_0017190 gocheck_do_not_annotate GO:0042112 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042112 GO:0042111 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042111 GO:0042114 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042114 GO:0042113 biolink:BiologicalProcess B cell activation The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json B lymphocyte activation|B-cell activation|B-lymphocyte activation http://purl.obolibrary.org/obo/GO_0042113 GO:0042110 biolink:BiologicalProcess T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json T lymphocyte activation|T-cell activation|T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0042110 GO:0042119 biolink:BiologicalProcess neutrophil activation The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0042119 GO:0042116 biolink:BiologicalProcess macrophage activation A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json macrophage polarization http://purl.obolibrary.org/obo/GO_0042116 GO:0042115 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042115 GO:0042118 biolink:BiologicalProcess endothelial cell activation The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0042118 GO:0042117 biolink:BiologicalProcess monocyte activation The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0042117 GO:0017189 biolink:BiologicalProcess N-terminal peptidyl-alanine acetylation The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase. RESID:AA0041 go.json http://purl.obolibrary.org/obo/GO_0017189 gocheck_do_not_annotate GO:0017188 biolink:MolecularActivity aspartate N-acetyltransferase activity Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+. EC:2.3.1.17|KEGG_REACTION:R00487|MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN|RHEA:14165|Reactome:R-HSA-8954468 go.json L-aspartate N-acetyltransferase activity|acetyl-CoA:L-aspartate N-acetyltransferase activity|aspartate acetyltransferase activity http://purl.obolibrary.org/obo/GO_0017188 GO:0017185 biolink:BiologicalProcess peptidyl-lysine hydroxylation The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine. go.json http://purl.obolibrary.org/obo/GO_0017185 gocheck_do_not_annotate GO:0017184 biolink:BiologicalProcess obsolete peptidyl-diphthamide catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue. go.json peptidyl-diphthamide breakdown|peptidyl-diphthamide catabolism|peptidyl-diphthamide degradation True http://purl.obolibrary.org/obo/GO_0017184 GO:0017187 biolink:BiologicalProcess peptidyl-glutamic acid carboxylation The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. RESID:AA0032 go.json http://purl.obolibrary.org/obo/GO_0017187 gocheck_do_not_annotate GO:0017186 biolink:BiologicalProcess peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase. RESID:AA0031 go.json 2-pyrrolidone-5-carboxylic acid biosynthesis|2-pyrrolidone-5-carboxylic acid biosynthetic process|peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase|peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase|peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase http://purl.obolibrary.org/obo/GO_0017186 gocheck_do_not_annotate GO:0140467 biolink:BiologicalProcess integrated stress response signaling The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. Wikipedia:Integrated_stress_response go.json ISR http://purl.obolibrary.org/obo/GO_0140467 GO:0140466 biolink:BiologicalProcess iron-sulfur cluster export from the mitochondrion The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane. go.json http://purl.obolibrary.org/obo/GO_0140466 GO:0140469 biolink:BiologicalProcess GCN2-mediated signaling A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation. go.json EIF2AK4-mediated signaling|regulation of eIF2 alpha phosphorylation by amino acid starvation http://purl.obolibrary.org/obo/GO_0140469 GO:0140468 biolink:BiologicalProcess HRI-mediated signaling A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. go.json EIF2AK1-mediated signaling http://purl.obolibrary.org/obo/GO_0140468 GO:0140461 biolink:BiologicalProcess obsolete subtelomeric heterochromatin organization OBSOLETE. The organization of chromatin into heterochromatin at the subtelomeric region of a chromosome. go.json True http://purl.obolibrary.org/obo/GO_0140461 GO:0140460 biolink:BiologicalProcess response to Gram-negative bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium. go.json http://purl.obolibrary.org/obo/GO_0140460 GO:0140463 biolink:MolecularActivity chromatin-protein adaptor activity The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex. go.json chromatin adaptor|chromatin adaptor activity|chromatin receptor|chromatin recruitment|chromatin-protein adaptor|protein-chromatin adaptor activity http://purl.obolibrary.org/obo/GO_0140463 GO:0140462 biolink:BiologicalProcess pericentric heterochromatin organization The organization of chromatin into heterochromatin at the pericentric region of a chromosome. go.json http://purl.obolibrary.org/obo/GO_0140462 GO:0140464 biolink:BiologicalProcess subnuclear spatial organization of silent mating-type cassette heterochromatin The localization of silent mating-type cassette heterochromatin at a specific location in the nucleus. go.json silent mating-type cassette heterochromatin organization|silent mating-type cassette heterochromatin spatial organization in the nucleus http://purl.obolibrary.org/obo/GO_0140464 GO:0140456 biolink:BiologicalProcess initial meiotic spindle pole body separation The release of duplicated meiotic spindle pole bodies (SPBs). go.json initial spindle pole body separation involved in meiosis I|meiotic spindle pole body duplication http://purl.obolibrary.org/obo/GO_0140456 GO:0140455 biolink:BiologicalProcess cytoplasm protein quality control The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. go.json http://purl.obolibrary.org/obo/GO_0140455 GO:0140458 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140458 GO:0140457 biolink:MolecularActivity protein demethylase activity Catalysis of the removal of a methyl group from a protein. go.json http://purl.obolibrary.org/obo/GO_0140457 GO:0140459 biolink:BiologicalProcess response to Gram-positive bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium. go.json http://purl.obolibrary.org/obo/GO_0140459 GO:0140450 biolink:BiologicalProcess protein targeting to Golgi apparatus The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation). go.json http://purl.obolibrary.org/obo/GO_0140450 GO:0140451 biolink:CellularComponent counting factor complex A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum. go.json http://purl.obolibrary.org/obo/GO_0140451 GO:0140454 biolink:BiologicalProcess protein aggregate center assembly The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. go.json PAC assembly|protein aggregate center formation|protein aggregate centre assembly http://purl.obolibrary.org/obo/GO_0140454 GO:0140453 biolink:CellularComponent protein aggregate center Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. go.json PAC|protein aggregate centre http://purl.obolibrary.org/obo/GO_0140453 GO:0140489 biolink:MolecularActivity molecular template activity The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence. go.json http://purl.obolibrary.org/obo/GO_0140489 GO:0140488 biolink:MolecularActivity heme receptor activity Binding specifically to heme to deliver it to a transport vesicle. go.json http://purl.obolibrary.org/obo/GO_0140488 GO:0140481 biolink:MolecularActivity ABC-type iron-sulfur cluster transporter activity Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out). TC:3.A.1.210.1 go.json ATPase-coupled Fe-S cluster transmembrane transporter activity|ATPase-coupled iron-sulfur cluster transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0140481 GO:0140480 biolink:BiologicalProcess mitotic spindle pole body insertion into the nuclear envelope A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane. go.json establishment of spindle pole body localisation in nuclear envelope|establishment of spindle pole body localization in nuclear envelope|establishment of spindle pole body localization to nuclear envelope http://purl.obolibrary.org/obo/GO_0140480 GO:0140483 biolink:MolecularActivity kinetochore adaptor activity The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way. go.json inner kinetochore adaptor activity|outer kinetochore adaptor activity http://purl.obolibrary.org/obo/GO_0140483 GO:0140482 biolink:MolecularActivity iron sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron. go.json http://purl.obolibrary.org/obo/GO_0140482 GO:0140485 biolink:MolecularActivity 5-aminolevulinic acid transmembrane transporter activity Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other. RHEA:64816 go.json http://purl.obolibrary.org/obo/GO_0140485 GO:0140484 biolink:BiologicalProcess 5-aminolevulinic acid import across plasma membrane The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140484 GO:0140487 biolink:MolecularActivity metal ion sequestering activity Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json http://purl.obolibrary.org/obo/GO_0140487 GO:0140486 biolink:MolecularActivity zinc ion sequestering activity Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json http://purl.obolibrary.org/obo/GO_0140486 GO:0140479 biolink:BiologicalProcess ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide. go.json http://purl.obolibrary.org/obo/GO_0140479 GO:0140472 biolink:CellularComponent cell cortex of non-growing cell tip The region directly beneath the plasma membrane at the cell tip at which no growth takes place. go.json http://purl.obolibrary.org/obo/GO_0140472 GO:0140471 biolink:BiologicalProcess positive regulation of transepithelial migration of symbiont in host Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host. go.json positive regulation of transmigration of symbiont in host http://purl.obolibrary.org/obo/GO_0140471 GO:0140474 biolink:MolecularActivity mitochondrion-endoplasmic reticulum membrane tether activity The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion. go.json ER-mitochondrion membrane adaptor activity|ER-mitochondrion membrane tether activity|endoplasmic reticulum-mitochondrion membrane adaptor activity|endoplasmic reticulum-mitochondrion membrane tether activity|mitochondrion-ER membrane adaptor activity|mitochondrion-ER membrane tether activity|mitochondrion-endoplasmic reticulum membrane adaptor activity http://purl.obolibrary.org/obo/GO_0140474 GO:0140473 biolink:MolecularActivity telomere-nuclear envelope anchor activity The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location. go.json nuclear envelope-telomere anchor activity|telomere-nuclear envelope anchoring activity http://purl.obolibrary.org/obo/GO_0140473 GO:0140475 biolink:MolecularActivity spindle pole body anchor activity The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way. go.json http://purl.obolibrary.org/obo/GO_0140475 GO:0140423 biolink:BiologicalProcess effector-mediated suppression of host pattern-triggered immunity signaling A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants. go.json effector-mediated suppression of PTI signalling|effector-mediated suppression of host PRR signaling|effector-mediated suppression of host PRR signalling|effector-mediated suppression of host pattern recognition receptor signaling|effector-mediated suppression of pattern-triggered immunity signaling http://purl.obolibrary.org/obo/GO_0140423 GO:0140425 biolink:BiologicalProcess galactose import across plasma membrane The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140425 GO:0140426 biolink:BiologicalProcess pathogen-associated molecular pattern receptor signaling pathway The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. go.json MAMP-triggered immunity signalling|PAMP receptor signaling pathway|PAMP-triggered immunity signalling pathway|PTI signalling|pathogen-associated molecular pattern signalling http://purl.obolibrary.org/obo/GO_0140426 GO:0140429 biolink:BiologicalProcess positive regulation of mitotic sister chromatid biorientation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. go.json correction of merotelic kinetochore attachment, mitotic|correction of mono-orientation defects|correction of syntelic kinetochore attachment, mitotic|repair of mitotic merotelic kinetochore attachment defect|repair of mitotic merotelic kinetochore attachment defects|repair of mitotic mono-orientation defect|repair of mitotic mono-orientation defects http://purl.obolibrary.org/obo/GO_0140429 GO:0140421 biolink:BiologicalProcess endocytic heme import into cell The directed movement into cell of externally available heme by receptor-mediated endocytosis. go.json heme assimilation http://purl.obolibrary.org/obo/GO_0140421 GO:0140420 biolink:BiologicalProcess heme import into cell The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. go.json heme assimilation http://purl.obolibrary.org/obo/GO_0140420 GO:0140412 biolink:MolecularActivity zinc:bicarbonate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in). go.json http://purl.obolibrary.org/obo/GO_0140412 GO:0140414 biolink:MolecularActivity phosphopantetheine-dependent carrier activity Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate. go.json carrier protein activity http://purl.obolibrary.org/obo/GO_0140414 GO:0140413 biolink:MolecularActivity zinc:bicarbonate:selenite symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out). go.json http://purl.obolibrary.org/obo/GO_0140413 GO:0140416 biolink:MolecularActivity transcription regulator inhibitor activity A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. go.json DNA-binding transcription factor inhibitor activity http://purl.obolibrary.org/obo/GO_0140416 GO:0140415 biolink:BiologicalProcess effector-mediated modulation of host defenses by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0140415 GO:0140418 biolink:BiologicalProcess effector-mediated modulation of host process by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json effector mediated modulation of host process by symbiont|effector triggered modulation of host process by symbiont|effector-dependent modulation of host process by symbiont http://purl.obolibrary.org/obo/GO_0140418 GO:0140417 biolink:MolecularActivity ATP-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0140417 GO:0140410 biolink:MolecularActivity monoatomic cation:bicarbonate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in). go.json solute:bicarbonate symporter activity http://purl.obolibrary.org/obo/GO_0140410 GO:0140445 biolink:CellularComponent chromosome, telomeric repeat region A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop. go.json http://purl.obolibrary.org/obo/GO_0140445 GO:0140444 biolink:MolecularActivity cytoskeleton-nuclear membrane anchor activity The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. go.json cytoskeletal protein-nuclear membrane adaptor activity|cytoskeletal protein-nuclear membrane anchor activity|cytoskeleton nuclear membrane anchor activity|nuclear membrane-cytoskeleton anchor activity http://purl.obolibrary.org/obo/GO_0140444 GO:0140447 biolink:BiologicalProcess cytokine precursor processing The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine. go.json interleukin maturation|interleukin processing http://purl.obolibrary.org/obo/GO_0140447 GO:0140446 biolink:BiologicalProcess fumigermin biosynthetic process The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus. go.json fumigermin anabolism|fumigermin biosynthesis|fumigermin formation|fumigermin synthesis http://purl.obolibrary.org/obo/GO_0140446 GO:0140449 biolink:MolecularActivity centromere-nuclear envelope anchor activity The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location. go.json centromere nuclear envelope anchor activity|centromere nuclear envelope tether activity|centromere-inner nuclear envelope anchor activity|centromere-inner nuclear envelope tether activity|chromosome, centromeric region-nuclear envelope anchor activity|nuclear envelope-centromere anchor activity|nuclear envelope-centromere tether activity http://purl.obolibrary.org/obo/GO_0140449 GO:0140448 biolink:BiologicalProcess signaling receptor ligand precursor processing The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand. go.json ligand maturation|signal maturation http://purl.obolibrary.org/obo/GO_0140448 GO:0140441 biolink:MolecularActivity protein-cysteine S-arachidonoyltransferase activity Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]. RHEA:59748 go.json http://purl.obolibrary.org/obo/GO_0140441 GO:0140440 biolink:MolecularActivity protein-cysteine S-oleoyltransferase activity Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]. RHEA:59744 go.json http://purl.obolibrary.org/obo/GO_0140440 GO:0140443 biolink:MolecularActivity mitochondrion-plasma membrane adaptor activity The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion. go.json mitochondrion plasma membrane adaptor activity|mitochondrion plasma membrane tether activity|plasma membrane-mitochondrion adaptor activity|plasma membrane-mitochondrion tether activity http://purl.obolibrary.org/obo/GO_0140443 GO:0140442 biolink:MolecularActivity peroxide sensor activity Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. go.json http://purl.obolibrary.org/obo/GO_0140442 GO:0140434 biolink:BiologicalProcess positive regulation of protein localization to meiotic spindle pole body Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0140434 GO:0140433 biolink:BiologicalProcess regulation of protein localization to meiotic spindle pole body Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0140433 GO:0140435 biolink:BiologicalProcess negative regulation of protein localization to meiotic spindle pole body Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body. go.json http://purl.obolibrary.org/obo/GO_0140435 GO:0140438 biolink:BiologicalProcess protein stearoylation The covalent attachment of a stearoyl group to an amino acid in a protein. go.json http://purl.obolibrary.org/obo/GO_0140438 gocheck_do_not_annotate GO:0140439 biolink:MolecularActivity protein-cysteine S-stearoyltransferase activity Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. RHEA:59740 go.json http://purl.obolibrary.org/obo/GO_0140439 GO:0140430 biolink:BiologicalProcess positive regulation of chromosome passenger complex localization to kinetochore Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore. go.json http://purl.obolibrary.org/obo/GO_0140430 GO:0140432 biolink:MolecularActivity 5'-hydroxyl dinucleotide hydrolase activity Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA. go.json http://purl.obolibrary.org/obo/GO_0140432 GO:0140431 biolink:MolecularActivity DNA-(abasic site) binding Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base. go.json DNA AP site binding|DNA-(apurinic site) binding|DNA-(apurinic site/apyrimidinic site) binding|DNA-(apyrimidinic site) binding http://purl.obolibrary.org/obo/GO_0140431 GO:0042082 biolink:BiologicalProcess GSI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage. go.json GPI/GSI anchor biosynthesis|GPI/GSI anchor biosynthetic process|GSI anchor anabolism|GSI anchor biosynthesis|GSI anchor formation|GSI anchor synthesis http://purl.obolibrary.org/obo/GO_0042082 gocheck_do_not_annotate GO:0032717 biolink:BiologicalProcess negative regulation of interleukin-8 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. go.json down regulation of interleukin-8 production|down-regulation of interleukin-8 production|downregulation of interleukin-8 production|inhibition of interleukin-8 production|negative regulation of IL-8 production|negative regulation of interleukin-8 biosynthetic process|negative regulation of interleukin-8 secretion http://purl.obolibrary.org/obo/GO_0032717 GO:0042081 biolink:BiologicalProcess GSI anchor metabolic process The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane. go.json GPI/GSI anchor metabolic process|GPI/GSI anchor metabolism|GSI anchor metabolism http://purl.obolibrary.org/obo/GO_0042081 GO:0032716 biolink:BiologicalProcess negative regulation of interleukin-7 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production. go.json down regulation of interleukin-7 production|down-regulation of interleukin-7 production|downregulation of interleukin-7 production|inhibition of interleukin-7 production|negative regulation of IL-7 production|negative regulation of interleukin-7 biosynthetic process|negative regulation of interleukin-7 secretion http://purl.obolibrary.org/obo/GO_0032716 GO:0032715 biolink:BiologicalProcess negative regulation of interleukin-6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. go.json down regulation of interleukin-6 production|down-regulation of interleukin-6 production|downregulation of interleukin-6 production|inhibition of interleukin-6 production|negative regulation of IL-6 production|negative regulation of interleukin-6 biosynthetic process|negative regulation of interleukin-6 secretion http://purl.obolibrary.org/obo/GO_0032715 GO:0042084 biolink:MolecularActivity 5-methyltetrahydrofolate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. go.json http://purl.obolibrary.org/obo/GO_0042084 GO:0032714 biolink:BiologicalProcess negative regulation of interleukin-5 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production. go.json down regulation of interleukin-5 production|down-regulation of interleukin-5 production|downregulation of interleukin-5 production|inhibition of interleukin-5 production|negative regulation of IL-5 production|negative regulation of interleukin-5 biosynthetic process|negative regulation of interleukin-5 secretion http://purl.obolibrary.org/obo/GO_0032714 GO:0042083 biolink:MolecularActivity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. go.json http://purl.obolibrary.org/obo/GO_0042083 GO:0032713 biolink:BiologicalProcess negative regulation of interleukin-4 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production. go.json down regulation of interleukin-4 production|down-regulation of interleukin-4 production|downregulation of interleukin-4 production|inhibition of interleukin-4 production|negative regulation of IL-4 production|negative regulation of interleukin-4 biosynthetic process|negative regulation of interleukin-4 secretion http://purl.obolibrary.org/obo/GO_0032713 GO:0032712 biolink:BiologicalProcess negative regulation of interleukin-3 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production. go.json down regulation of interleukin-3 production|down-regulation of interleukin-3 production|downregulation of interleukin-3 production|inhibition of interleukin-3 production|negative regulation of IL-3 production|negative regulation of interleukin-3 biosynthetic process http://purl.obolibrary.org/obo/GO_0032712 GO:0032711 biolink:BiologicalProcess negative regulation of interleukin-27 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production. go.json down regulation of interleukin-27 production|down-regulation of interleukin-27 production|downregulation of interleukin-27 production|inhibition of interleukin-27 production|negative regulation of IL-27 production|negative regulation of interleukin-27 biosynthetic process http://purl.obolibrary.org/obo/GO_0032711 GO:0042080 biolink:BiologicalProcess obsolete GPI/GSI anchor biosynthetic process OBSOLETE. (Was not defined before being made obsolete). go.json GPI/GSI anchor anabolism|GPI/GSI anchor biosynthesis|GPI/GSI anchor biosynthetic process|GPI/GSI anchor formation|GPI/GSI anchor synthesis True http://purl.obolibrary.org/obo/GO_0042080 GO:0032710 biolink:BiologicalProcess negative regulation of interleukin-26 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production. go.json down regulation of interleukin-26 production|down-regulation of interleukin-26 production|downregulation of interleukin-26 production|inhibition of interleukin-26 production|negative regulation of IL-26 production|negative regulation of interleukin-26 biosynthetic process http://purl.obolibrary.org/obo/GO_0032710 GO:0042089 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042089 GO:0042086 biolink:MolecularActivity 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin. go.json http://purl.obolibrary.org/obo/GO_0042086 GO:0042085 biolink:MolecularActivity 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate. go.json http://purl.obolibrary.org/obo/GO_0042085 GO:0032719 biolink:BiologicalProcess negative regulation of TRAIL production Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production. go.json down regulation of TRAIL production|down-regulation of TRAIL production|downregulation of TRAIL production|inhibition of TRAIL production|negative regulation of TRAIL biosynthetic process http://purl.obolibrary.org/obo/GO_0032719 GO:0042088 biolink:BiologicalProcess T-helper 1 type immune response An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. go.json Th1 immune response http://purl.obolibrary.org/obo/GO_0042088 GO:0032718 biolink:BiologicalProcess negative regulation of interleukin-9 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production. go.json down regulation of interleukin-9 production|down-regulation of interleukin-9 production|downregulation of interleukin-9 production|inhibition of interleukin-9 production|negative regulation of IL-9 production|negative regulation of interleukin-9 biosynthetic process http://purl.obolibrary.org/obo/GO_0032718 GO:0042087 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042087 GO:0032706 biolink:BiologicalProcess negative regulation of interleukin-22 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production. go.json down regulation of interleukin-22 production|down-regulation of interleukin-22 production|downregulation of interleukin-22 production|inhibition of interleukin-22 production|negative regulation of IL-22 production|negative regulation of interleukin-22 biosynthetic process http://purl.obolibrary.org/obo/GO_0032706 GO:0042093 biolink:BiologicalProcess T-helper cell differentiation The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. go.json T-helper cell development|helper T cell differentiation http://purl.obolibrary.org/obo/GO_0042093 GO:0032705 biolink:BiologicalProcess negative regulation of interleukin-21 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production. go.json down regulation of interleukin-21 production|down-regulation of interleukin-21 production|downregulation of interleukin-21 production|negative regulation of interleukin-21 biosynthetic process http://purl.obolibrary.org/obo/GO_0032705 GO:0042092 biolink:BiologicalProcess type 2 immune response An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. go.json T-helper 2 type immune response|Th2 immune response http://purl.obolibrary.org/obo/GO_0042092 GO:0032704 biolink:BiologicalProcess negative regulation of interleukin-20 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production. go.json down regulation of interleukin-20 production|down-regulation of interleukin-20 production|downregulation of interleukin-20 production|inhibition of interleukin-20 production|negative regulation of IL-20 production|negative regulation of interleukin-20 biosynthetic process http://purl.obolibrary.org/obo/GO_0032704 GO:0042095 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042095 GO:0032703 biolink:BiologicalProcess negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. go.json down regulation of interleukin-2 production|down-regulation of interleukin-2 production|downregulation of interleukin-2 production|inhibition of interleukin-2 production|negative regulation of IL-2 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 secretion http://purl.obolibrary.org/obo/GO_0032703 GO:0042094 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042094 GO:0032702 biolink:BiologicalProcess negative regulation of interleukin-19 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production. go.json down regulation of interleukin-19 production|down-regulation of interleukin-19 production|downregulation of interleukin-19 production|inhibition of interleukin-19 production|negative regulation of IL-19 production|negative regulation of interleukin-19 biosynthetic process http://purl.obolibrary.org/obo/GO_0032702 GO:0032701 biolink:BiologicalProcess negative regulation of interleukin-18 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production. go.json down regulation of interleukin-18 production|down-regulation of interleukin-18 production|downregulation of interleukin-18 production|inhibition of interleukin-18 production|negative regulation of IL-18 production|negative regulation of interleukin-18 biosynthetic process|negative regulation of interleukin-18 secretion http://purl.obolibrary.org/obo/GO_0032701 GO:0032700 biolink:BiologicalProcess negative regulation of interleukin-17 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. go.json down regulation of interleukin-17 production|downregulation of interleukin-17 production|inhibition of interleukin-17 production|negative regulation of CTLA-8 production|negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion|negative regulation of IL-17 production|negative regulation of interleukin-17 biosynthetic process|negative regulation of interleukin-17 secretion http://purl.obolibrary.org/obo/GO_0032700 GO:0042091 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042091 GO:0042090 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042090 GO:0042097 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042097 GO:0032709 biolink:BiologicalProcess negative regulation of interleukin-25 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production. go.json down regulation of interleukin-25 production|down-regulation of interleukin-25 production|downregulation of interleukin-25 production|inhibition of interleukin-25 production|negative regulation of IL-25 production|negative regulation of interleukin-25 biosynthetic process|negative regulation of interleukin-25 secretion http://purl.obolibrary.org/obo/GO_0032709 GO:0042096 biolink:MolecularActivity obsolete alpha-beta T cell receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json alpha-beta T cell receptor activity True http://purl.obolibrary.org/obo/GO_0042096 GO:0032708 biolink:BiologicalProcess negative regulation of interleukin-24 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production. go.json down regulation of interleukin-24 production|down-regulation of interleukin-24 production|downregulation of interleukin-24 production|inhibition of interleukin-24 production|negative regulation of IL-24 production|negative regulation of interleukin-24 biosynthetic process http://purl.obolibrary.org/obo/GO_0032708 GO:0042099 biolink:MolecularActivity obsolete gamma-delta T cell receptor activity OBSOLETE. (Was not defined before being made obsolete). go.json gamma-delta T cell receptor activity True http://purl.obolibrary.org/obo/GO_0042099 GO:0042098 biolink:BiologicalProcess T cell proliferation The expansion of a T cell population by cell division. Follows T cell activation. go.json T lymphocyte proliferation|T-cell proliferation|T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0042098 GO:0032707 biolink:BiologicalProcess negative regulation of interleukin-23 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production. go.json down regulation of interleukin-23 production|down-regulation of interleukin-23 production|downregulation of interleukin-23 production|inhibition of interleukin-23 production|negative regulation of IL-23 production|negative regulation of interleukin-23 biosynthetic process http://purl.obolibrary.org/obo/GO_0032707 GO:0140499 biolink:BiologicalProcess negative regulation of mitotic spindle assembly checkpoint signaling Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling. go.json http://purl.obolibrary.org/obo/GO_0140499 GO:0140492 biolink:MolecularActivity metal-dependent deubiquitinase activity An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. go.json metal-dependent ubiquitin-like hydrolase activity|metal-dependent ubiquitinyl-like hydrolase activity http://purl.obolibrary.org/obo/GO_0140492 GO:0140491 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140491 GO:0140494 biolink:CellularComponent migrasome A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration. go.json http://purl.obolibrary.org/obo/GO_0140494 GO:0140493 biolink:BiologicalProcess very long-chain fatty acid beta-oxidation A fatty acid beta-oxidation pathway acting on a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). go.json http://purl.obolibrary.org/obo/GO_0140493 GO:0140496 biolink:MolecularActivity gamma-tubulin complex binding Binding to a gamma-tubulin complex. go.json http://purl.obolibrary.org/obo/GO_0140496 GO:0140495 biolink:BiologicalProcess migracytosis A cell migration-dependent mechanism for releasing cellular contents. go.json http://purl.obolibrary.org/obo/GO_0140495 GO:0140498 biolink:CellularComponent mannan polymerase I complex A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p. go.json http://purl.obolibrary.org/obo/GO_0140498 GO:0140497 biolink:CellularComponent mannan polymerase II complex A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p. go.json http://purl.obolibrary.org/obo/GO_0140497 GO:0140490 biolink:MolecularActivity microtubule nucleator activity The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly. go.json microtubule nucleation template activity http://purl.obolibrary.org/obo/GO_0140490 GO:0042244 biolink:BiologicalProcess spore wall assembly The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore. go.json spore coat biosynthesis|spore coat biosynthetic process|spore wall formation http://purl.obolibrary.org/obo/GO_0042244 GO:0042243 biolink:BiologicalProcess asexual spore wall assembly The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species. go.json asexual spore wall formation http://purl.obolibrary.org/obo/GO_0042243 GO:0042246 biolink:BiologicalProcess tissue regeneration The regrowth of lost or destroyed tissues. go.json http://purl.obolibrary.org/obo/GO_0042246 GO:0042245 biolink:BiologicalProcess RNA repair Any process that results in the repair of damaged RNA. go.json http://purl.obolibrary.org/obo/GO_0042245 GO:0042240 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042240 GO:0042242 biolink:MolecularActivity cobyrinic acid a,c-diamide synthase activity Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. EC:6.3.5.11|RHEA:26289 go.json CobB|cobyrinate a c diamide synthase activity|cobyrinate a c-diamide synthase activity|cobyrinate a,c diamide synthase activity|cobyrinate a,c-diamide synthase activity http://purl.obolibrary.org/obo/GO_0042242 GO:0042241 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042241 GO:0042248 biolink:BiologicalProcess maintenance of polarity of follicular epithelium The maintenance of an established polarized follicular epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0042248 GO:0042247 biolink:BiologicalProcess establishment of planar polarity of follicular epithelium Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates. go.json http://purl.obolibrary.org/obo/GO_0042247 GO:0042249 biolink:BiologicalProcess establishment of planar polarity of embryonic epithelium Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates. go.json http://purl.obolibrary.org/obo/GO_0042249 GO:0042255 biolink:BiologicalProcess ribosome assembly The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. go.json ribosomal subunit assembly http://purl.obolibrary.org/obo/GO_0042255 goslim_yeast GO:0042254 biolink:BiologicalProcess ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. go.json ribosome biogenesis and assembly http://purl.obolibrary.org/obo/GO_0042254 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|prokaryote_subset GO:0042257 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042257 GO:0042256 biolink:BiologicalProcess cytosolic ribosome assembly The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. go.json mature ribosome assembly http://purl.obolibrary.org/obo/GO_0042256 GO:0042251 biolink:BiologicalProcess maintenance of polarity of larval imaginal disc epithelium The maintenance of an established polarized larval imaginal disc epithelium. go.json http://purl.obolibrary.org/obo/GO_0042251 GO:0042250 biolink:BiologicalProcess maintenance of polarity of embryonic epithelium The maintenance of an established polarized embryonic epithelial sheet. go.json http://purl.obolibrary.org/obo/GO_0042250 GO:0042253 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042253 GO:0042252 biolink:BiologicalProcess establishment of planar polarity of larval imaginal disc epithelium Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates. go.json http://purl.obolibrary.org/obo/GO_0042252 GO:0042259 biolink:BiologicalProcess obsolete peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine OBSOLETE. The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12. go.json peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine|peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine|peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine True http://purl.obolibrary.org/obo/GO_0042259 GO:0042258 biolink:BiologicalProcess molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide. RESID:AA0319 go.json http://purl.obolibrary.org/obo/GO_0042258 gocheck_do_not_annotate GO:0042260 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042260 GO:0032899 biolink:BiologicalProcess regulation of neurotrophin production Any process that modulates the frequency, rate, or extent of production of a neurotrophin. go.json http://purl.obolibrary.org/obo/GO_0032899 GO:0032898 biolink:BiologicalProcess neurotrophin production The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. go.json http://purl.obolibrary.org/obo/GO_0032898 GO:0032897 biolink:BiologicalProcess negative regulation of viral transcription Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. go.json down regulation of viral transcription|down-regulation of viral transcription|downregulation of viral transcription|inhibition of viral transcription http://purl.obolibrary.org/obo/GO_0032897 GO:0042266 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042266 GO:0042265 biolink:BiologicalProcess obsolete peptidyl-asparagine hydroxylation OBSOLETE. The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine. go.json peptidyl-aspartic acid/asparagine hydroxylation True http://purl.obolibrary.org/obo/GO_0042265 GO:0042268 biolink:BiologicalProcess regulation of cytolysis Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0042268 GO:0042267 biolink:BiologicalProcess natural killer cell mediated cytotoxicity The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. go.json NK cell mediated cell death|NK cell mediated cell killing|NK cell mediated cytolysis|NK cell mediated cytotoxicity|killer activity|natural killer cell mediated cell death|natural killer cell mediated cell killing|natural killer cell mediated cytolysis|natural killer-cell mediated cytolysis http://purl.obolibrary.org/obo/GO_0042267 GO:0042262 biolink:BiologicalProcess DNA protection Any process in which DNA is protected from damage by, for example, oxidative stress. go.json http://purl.obolibrary.org/obo/GO_0042262 GO:0042261 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042261 GO:0042264 biolink:BiologicalProcess peptidyl-aspartic acid hydroxylation The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid. go.json peptidyl-aspartic acid/asparagine hydroxylation http://purl.obolibrary.org/obo/GO_0042264 gocheck_do_not_annotate GO:0042263 biolink:MolecularActivity neuropeptide F receptor activity Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa. go.json NPF receptor activity http://purl.obolibrary.org/obo/GO_0042263 GO:0042269 biolink:BiologicalProcess regulation of natural killer cell mediated cytotoxicity Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity. go.json regulation of NK cell mediated cell death|regulation of NK cell mediated cell killing|regulation of NK cell mediated cytolysis|regulation of NK cell mediated cytotoxicity|regulation of natural killer cell mediated cell death|regulation of natural killer cell mediated cell killing|regulation of natural killer cell mediated cytolysis|regulation of natural killer-cell mediated cytolysis http://purl.obolibrary.org/obo/GO_0042269 GO:0032896 biolink:MolecularActivity palmitoyl-CoA 9-desaturase activity Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O. go.json palmitoyl-CoA delta9-desaturase acitivity http://purl.obolibrary.org/obo/GO_0032896 GO:0032895 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032895 GO:0032894 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032894 GO:0032893 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032893 GO:0032892 biolink:BiologicalProcess positive regulation of organic acid transport Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of organic acid transport|stimulation of organic acid transport|up regulation of organic acid transport|up-regulation of organic acid transport|upregulation of organic acid transport http://purl.obolibrary.org/obo/GO_0032892 GO:0032891 biolink:BiologicalProcess negative regulation of organic acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of organic acid transport|down-regulation of organic acid transport|downregulation of organic acid transport|inhibition of organic acid transport http://purl.obolibrary.org/obo/GO_0032891 GO:0032890 biolink:BiologicalProcess regulation of organic acid transport Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032890 GO:0042271 biolink:BiologicalProcess susceptibility to natural killer cell mediated cytotoxicity The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity. go.json susceptibility to NK cell mediated cell death|susceptibility to NK cell mediated cell killing|susceptibility to NK cell mediated cytolysis|susceptibility to NK cell mediated cytotoxicity|susceptibility to natural killer cell mediated cell death|susceptibility to natural killer cell mediated cell killing|susceptibility to natural killer cell mediated cytolysis http://purl.obolibrary.org/obo/GO_0042271 GO:0042270 biolink:BiologicalProcess protection from natural killer cell mediated cytotoxicity The process of protecting a cell from natural killer cell mediated cytotoxicity. go.json protection from NK cell mediated cell death|protection from NK cell mediated cell killing|protection from NK cell mediated cytolysis|protection from NK cell mediated cytotoxicity|protection from natural killer cell mediated cell death|protection from natural killer cell mediated cell killing|protection from natural killer cell mediated cytolysis http://purl.obolibrary.org/obo/GO_0042270 GO:0032889 biolink:BiologicalProcess regulation of vacuole fusion, non-autophagic Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. go.json http://purl.obolibrary.org/obo/GO_0032889 GO:0032888 biolink:BiologicalProcess regulation of mitotic spindle elongation Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle. go.json http://purl.obolibrary.org/obo/GO_0032888 GO:0032887 biolink:BiologicalProcess regulation of spindle elongation Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle. go.json http://purl.obolibrary.org/obo/GO_0032887 GO:0032886 biolink:BiologicalProcess regulation of microtubule-based process Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0032886 GO:0042277 biolink:MolecularActivity peptide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. go.json http://purl.obolibrary.org/obo/GO_0042277 goslim_chembl|goslim_pir GO:0042276 biolink:BiologicalProcess error-prone translesion synthesis The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. go.json error-prone postreplication DNA repair|mutagenic PRR|mutagenic postreplication DNA repair http://purl.obolibrary.org/obo/GO_0042276 GO:0042279 biolink:MolecularActivity nitrite reductase (cytochrome, ammonia-forming) activity Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+. EC:1.7.2.2|MetaCyc:1.7.2.2-RXN|RHEA:13089|Wikipedia:Cytochrome_c_nitrite_reductase go.json ammonia:ferricytochrome-c oxidoreductase activity|cytochrome c nitrite reductase activity|cytochrome c552 activity|multiheme nitrite reductase activity|nitrite reductase (cytochrome; ammonia-forming) http://purl.obolibrary.org/obo/GO_0042279 GO:0042278 biolink:BiologicalProcess purine nucleoside metabolic process The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json purine metabolic process|purine metabolism|purine nucleoside metabolism http://purl.obolibrary.org/obo/GO_0042278 GO:0042273 biolink:BiologicalProcess ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. go.json ribosomal large subunit biogenesis and assembly http://purl.obolibrary.org/obo/GO_0042273 goslim_yeast GO:0042272 biolink:CellularComponent nuclear RNA export factor complex A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. go.json Mex67-Mtr2 complex|NXF1-NXT1 complex|TAP-p15 complex http://purl.obolibrary.org/obo/GO_0042272 GO:0042275 biolink:BiologicalProcess error-free postreplication DNA repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate. go.json error-free PRR|error-free replication restart http://purl.obolibrary.org/obo/GO_0042275 GO:0042274 biolink:BiologicalProcess ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. go.json ribosomal small subunit biogenesis and assembly http://purl.obolibrary.org/obo/GO_0042274 goslim_yeast GO:0032885 biolink:BiologicalProcess regulation of polysaccharide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. go.json http://purl.obolibrary.org/obo/GO_0032885 GO:0032884 biolink:BiologicalProcess regulation of cell wall chitin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin. go.json regulation of cell wall chitin anabolism|regulation of cell wall chitin biosynthesis|regulation of cell wall chitin formation|regulation of cell wall chitin synthesis http://purl.obolibrary.org/obo/GO_0032884 GO:0032883 biolink:BiologicalProcess regulation of chitin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin. go.json regulation of chitin anabolism|regulation of chitin biosynthesis|regulation of chitin formation|regulation of chitin synthesis http://purl.obolibrary.org/obo/GO_0032883 GO:0032882 biolink:BiologicalProcess regulation of chitin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin. go.json regulation of chitin metabolism http://purl.obolibrary.org/obo/GO_0032882 GO:0032881 biolink:BiologicalProcess regulation of polysaccharide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. go.json http://purl.obolibrary.org/obo/GO_0032881 GO:0032880 biolink:BiologicalProcess regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. go.json regulation of cellular protein localisation|regulation of cellular protein localization|regulation of protein localisation http://purl.obolibrary.org/obo/GO_0032880 goslim_chembl GO:0042280 biolink:MolecularActivity obsolete cell surface antigen activity, host-interacting OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition. go.json cell surface antigen activity, host-interacting True http://purl.obolibrary.org/obo/GO_0042280 GO:0042282 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042282 GO:0042281 biolink:MolecularActivity dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. EC:2.4.1.267|MetaCyc:RXN-5470|RHEA:30635 go.json dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0042281 GO:0032879 biolink:BiologicalProcess regulation of localization Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. go.json regulation of localisation http://purl.obolibrary.org/obo/GO_0032879 GO:0032878 biolink:BiologicalProcess regulation of establishment or maintenance of cell polarity Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. go.json http://purl.obolibrary.org/obo/GO_0032878 GO:0032877 biolink:BiologicalProcess positive regulation of DNA endoreduplication Any process that activates or increases the frequency, rate or extent of DNA endoreduplication. go.json activation of DNA endoreduplication|positive regulation of DNA endoreplication|positive regulation of DNA re-duplication|stimulation of DNA endoreduplication|up regulation of DNA endoreduplication|up-regulation of DNA endoreduplication|upregulation of DNA endoreduplication http://purl.obolibrary.org/obo/GO_0032877 GO:0032876 biolink:BiologicalProcess negative regulation of DNA endoreduplication Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication. go.json down regulation of DNA endoreduplication|down-regulation of DNA endoreduplication|downregulation of DNA endoreduplication|inhibition of DNA endoreduplication|negative regulation of DNA endoreplication|negative regulation of DNA re-duplication http://purl.obolibrary.org/obo/GO_0032876 GO:0032875 biolink:BiologicalProcess regulation of DNA endoreduplication Any process that modulates the frequency, rate or extent of DNA endoreduplication. go.json regulation of DNA endoreplication|regulation of DNA re-duplication http://purl.obolibrary.org/obo/GO_0032875 GO:0042288 biolink:MolecularActivity MHC class I protein binding Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. go.json T cell receptor activity|alpha-beta T cell receptor activity|gamma-delta T cell receptor activity|major histocompatibility complex class I binding|major histocompatibility complex class I ligand http://purl.obolibrary.org/obo/GO_0042288 GO:0042287 biolink:MolecularActivity MHC protein binding Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. go.json major histocompatibility complex binding|major histocompatibility complex ligand http://purl.obolibrary.org/obo/GO_0042287 GO:0042289 biolink:MolecularActivity MHC class II protein binding Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. go.json major histocompatibility complex class II binding|major histocompatibility complex class II ligand http://purl.obolibrary.org/obo/GO_0042289 GO:0042284 biolink:MolecularActivity sphingolipid delta-4 desaturase activity Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O. EC:1.14.19.17|RHEA:46544|Reactome:R-HSA-428259 go.json delta-4 sphingolipid desaturase activity http://purl.obolibrary.org/obo/GO_0042284 GO:0042283 biolink:MolecularActivity dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. EC:2.4.1.265|MetaCyc:RXN-5471|RHEA:31307 go.json dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0042283 GO:0042286 biolink:MolecularActivity glutamate-1-semialdehyde 2,1-aminomutase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. EC:5.4.3.8|KEGG_REACTION:R02272|MetaCyc:GSAAMINOTRANS-RXN|RHEA:14265 go.json (S)-4-amino-5-oxopentanoate 4,5-aminomutase activity|glutamate-1-semialdehyde aminotransferase activity http://purl.obolibrary.org/obo/GO_0042286 GO:0042285 biolink:MolecularActivity xylosyltransferase activity Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. go.json http://purl.obolibrary.org/obo/GO_0042285 GO:0032874 biolink:BiologicalProcess positive regulation of stress-activated MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. go.json activation of stress-activated MAPK cascade|positive regulation of p38 MAPK signaling|positive regulation of p38 MAPK signalling|positive regulation of stress-activated MAPK signaling pathway|positive regulation of stress-activated MAPK signalling pathway|positive regulation of stress-activated MAPKKK cascade|positive regulation of stress-activated MAPKKK signaling pathway|positive regulation of stress-activated MAPKKK signalling pathway|stimulation of stress-activated MAPK cascade|up regulation of stress-activated MAPK cascade|up-regulation of stress-activated MAPK cascade|upregulation of stress-activated MAPK cascade http://purl.obolibrary.org/obo/GO_0032874 GO:0032873 biolink:BiologicalProcess negative regulation of stress-activated MAPK cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. go.json down regulation of stress-activated MAPK cascade|down-regulation of stress-activated MAPK cascade|downregulation of stress-activated MAPK cascade|inhibition of stress-activated MAPK cascade|negative regulation of p38 MAPK signaling|negative regulation of p38 MAPK signalling|negative regulation of stress-activated MAPK signaling pathway|negative regulation of stress-activated MAPK signalling pathway|negative regulation of stress-activated MAPKKK cascade|negative regulation of stress-activated MAPKKK signaling pathway|negative regulation of stress-activated MAPKKK signalling pathway http://purl.obolibrary.org/obo/GO_0032873 GO:0032872 biolink:BiologicalProcess regulation of stress-activated MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. go.json regulation of p38 MAPK signaling|regulation of p38 MAPK signalling|regulation of stress-activated MAPK signaling pathway|regulation of stress-activated MAPK signalling pathway|regulation of stress-activated MAPKKK cascade|regulation of stress-activated MAPKKK signaling pathway|regulation of stress-activated MAPKKK signalling pathway http://purl.obolibrary.org/obo/GO_0032872 GO:0032871 biolink:BiologicalProcess regulation of karyogamy Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. go.json http://purl.obolibrary.org/obo/GO_0032871 GO:0032870 biolink:BiologicalProcess cellular response to hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_0032870 GO:0042291 biolink:MolecularActivity obsolete Hub1 hydrolase activity OBSOLETE. (Was not defined before being made obsolete). go.json Hub1 hydrolase activity True http://purl.obolibrary.org/obo/GO_0042291 GO:0042290 biolink:MolecularActivity obsolete URM1 hydrolase activity OBSOLETE. (Was not defined before being made obsolete). go.json URM1 hydrolase activity True http://purl.obolibrary.org/obo/GO_0042290 GO:0042293 biolink:MolecularActivity Hub1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond. go.json http://purl.obolibrary.org/obo/GO_0042293 GO:0032869 biolink:BiologicalProcess cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. go.json http://purl.obolibrary.org/obo/GO_0032869 GO:0032868 biolink:BiologicalProcess response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. go.json response to insulin stimulus http://purl.obolibrary.org/obo/GO_0032868 GO:0042292 biolink:MolecularActivity URM1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond. go.json http://purl.obolibrary.org/obo/GO_0042292 GO:0032867 biolink:MolecularActivity L-arabinose:NADP reductase activity Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+. KEGG_REACTION:R01759|MetaCyc:RXN-8772|RHEA:25229|SABIO-RK:1858 go.json arabinose reductase activity|arabinose:NADP reductase activity http://purl.obolibrary.org/obo/GO_0032867 GO:0032866 biolink:MolecularActivity D-xylose:NADP reductase activity Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+. MetaCyc:RXN-8773|RHEA:27445 go.json D-xylose reductase activity|xylose reductase activity http://purl.obolibrary.org/obo/GO_0032866 GO:0032865 biolink:CellularComponent ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. go.json ER-mitochondria encounter structure|MMM1 complex|Mdm10/Mdm12/Mmm1 complex|mitochore http://purl.obolibrary.org/obo/GO_0032865 GO:0032864 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032864 GO:0042299 biolink:MolecularActivity lupeol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol. EC:5.4.99.41|MetaCyc:RXN-111|RHEA:31383 go.json oxidosqualene:lupeol cyclase activity http://purl.obolibrary.org/obo/GO_0042299 GO:0042298 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042298 GO:0042295 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042295 GO:0042294 biolink:MolecularActivity URM1 transferase activity Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages. go.json http://purl.obolibrary.org/obo/GO_0042294 GO:0042297 biolink:BiologicalProcess vocal learning A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others. Wikipedia:Vocal_learning go.json http://purl.obolibrary.org/obo/GO_0042297 GO:0042296 biolink:MolecularActivity ISG15 transferase activity Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. Reactome:R-HSA-5653754 go.json ISG15 conjugating enzyme activity http://purl.obolibrary.org/obo/GO_0042296 GO:0032863 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032863 GO:0032862 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032862 GO:0032861 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032861 GO:0032860 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032860 GO:0032859 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032859 GO:0032858 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032858 GO:0032857 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032857 GO:0032856 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032856 GO:0032855 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032855 GO:0032854 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032854 GO:0032853 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032853 GO:0032852 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032852 GO:0032851 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032851 GO:0032850 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032850 GO:0032849 biolink:BiologicalProcess positive regulation of cellular pH reduction Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell. go.json activation of cellular pH reduction|positive regulation of cell pH reduction|positive regulation of cellular acidification|positive regulation of intracellular acidification|positive regulation of intracellular pH reduction|positive regulation of reduction of cellular pH|positive regulation of reduction of pH in cell|stimulation of cellular pH reduction|up regulation of cellular pH reduction|up-regulation of cellular pH reduction|upregulation of cellular pH reduction http://purl.obolibrary.org/obo/GO_0032849 GO:0032848 biolink:BiologicalProcess negative regulation of cellular pH reduction Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell. go.json down regulation of cellular pH reduction|down-regulation of cellular pH reduction|downregulation of cellular pH reduction|inhibition of cellular pH reduction|negative regulation of cell pH reduction|negative regulation of cellular acidification|negative regulation of intracellular acidification|negative regulation of intracellular pH reduction|negative regulation of reduction of cellular pH|negative regulation of reduction of pH in cell http://purl.obolibrary.org/obo/GO_0032848 GO:0032847 biolink:BiologicalProcess regulation of cellular pH reduction Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell. go.json regulation of cell pH reduction|regulation of cellular acidification|regulation of intracellular acidification|regulation of intracellular pH reduction|regulation of reduction of cellular pH|regulation of reduction of pH in cell http://purl.obolibrary.org/obo/GO_0032847 GO:0032846 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032846 GO:0032845 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032845 GO:0032844 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032844 GO:0032843 biolink:MolecularActivity hydroperoxide reductase activity Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol. go.json http://purl.obolibrary.org/obo/GO_0032843 GO:0032842 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032842 GO:0032841 biolink:MolecularActivity calcitonin binding Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid. go.json http://purl.obolibrary.org/obo/GO_0032841 GO:0032840 biolink:MolecularActivity intramolecular proline-rich ligand binding Binding to a proline-rich region within the same polypeptide. go.json intramolecular proline-rich region binding http://purl.obolibrary.org/obo/GO_0032840 GO:0140749 biolink:MolecularActivity phlorizin hydrolase activity Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin. go.json http://purl.obolibrary.org/obo/GO_0140749 GO:0140742 biolink:BiologicalProcess lncRNA transcription The transcription of lncRNAs, non-coding RNAs over 200 nucleotides in length, from a DNA template. go.json http://purl.obolibrary.org/obo/GO_0140742 GO:0140741 biolink:MolecularActivity tRNA-uracil-4 sulfurtransferase activity Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster = AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster. EC:2.8.1.4|MetaCyc:TRNA-S-TRANSFERASE-RXN|RHEA:24176 go.json tRNA U4 sulfurtransferase|tRNA uracil 4 sulfurtransferase|tRNA uracil 4-sulfurtransferase http://purl.obolibrary.org/obo/GO_0140741 GO:0140744 biolink:BiologicalProcess negative regulation of lncRNA transcription Any process that decreases the frequency, rate or extent of the synthesis of a lncRNA. go.json http://purl.obolibrary.org/obo/GO_0140744 GO:0140743 biolink:BiologicalProcess regulation of lncRNA transcription Any process that modulates the frequency, rate or extent of the synthesis of a lncRNA. go.json http://purl.obolibrary.org/obo/GO_0140743 GO:0140746 biolink:BiologicalProcess siRNA catabolic process The chemical reactions and pathways resulting in the breakdown of small interfering RNA transcripts (siRNAs). go.json http://purl.obolibrary.org/obo/GO_0140746 GO:0140745 biolink:BiologicalProcess siRNA transcription The transcription of a small interfering RNA from an RNA template. go.json http://purl.obolibrary.org/obo/GO_0140745 GO:0140748 biolink:BiologicalProcess positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0140748 GO:0140747 biolink:BiologicalProcess regulation of ncRNA transcription Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template. go.json http://purl.obolibrary.org/obo/GO_0140747 GO:0140740 biolink:MolecularActivity ADP-riboxanase activity Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide. RHEA:69500 go.json http://purl.obolibrary.org/obo/GO_0140740 GO:0140739 biolink:BiologicalProcess NLRP6 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex. go.json http://purl.obolibrary.org/obo/GO_0140739 GO:0140738 biolink:CellularComponent NLRP6 inflammasome complex An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11. go.json http://purl.obolibrary.org/obo/GO_0140738 GO:0140731 biolink:BiologicalProcess regulation of amphiregulin production Any process that modulates the frequency, rate, or extent of production of amphiregulin. go.json regulation of AREG production http://purl.obolibrary.org/obo/GO_0140731 GO:0140730 biolink:BiologicalProcess amphiregulin production The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. go.json AREG production http://purl.obolibrary.org/obo/GO_0140730 gocheck_do_not_annotate GO:0140733 biolink:MolecularActivity tRNA ligase activator activity Binds to and increases the activity of a tRNA ligase. go.json http://purl.obolibrary.org/obo/GO_0140733 GO:0140732 biolink:BiologicalProcess positive regulation of amphiregulin production Any process that activates or increases the frequency, rate or extent of production of amphiregulin. go.json positive regulation of AREG production http://purl.obolibrary.org/obo/GO_0140732 GO:0140735 biolink:BiologicalProcess lovastatin biosynthetic process The chemical reactions and pathways resulting in the formation of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). MetaCyc:PWY-7535|kegg.module:M00893 go.json lovastatin anabolism|lovastatin biosynthesis|lovastatin formation|lovastatin synthesis|mevacor anabolism|mevacor biosynthesis|mevacor biosynthetic process|mevacor formation|mevacor synthesis|mevinolin anabolism|mevinolin biosynthesis|mevinolin biosynthetic process|mevinolin formation,|mevinolin synthesis|monacolin K anabolism|monacolin K biosynthesis|monacolin K biosynthetic process|monacolin K formation|monacolin K synthesis http://purl.obolibrary.org/obo/GO_0140735 GO:0140734 biolink:BiologicalProcess ammonium excretion The elimination of ammonium ions from an excretory cell. go.json ammonia excretion http://purl.obolibrary.org/obo/GO_0140734 GO:0140737 biolink:CellularComponent encapsulin nanocompartment Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla. go.json protein nanocompartment http://purl.obolibrary.org/obo/GO_0140737 GO:0140736 biolink:BiologicalProcess positive regulation of lovastatin biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin. go.json positive regulation of mevacor biosynthetic process|positive regulation of mevinolin biosynthetic process|positive regulation of monacolin K biosynthetic process http://purl.obolibrary.org/obo/GO_0140736 GO:0140764 biolink:MolecularActivity small RNA binding translational repressor activity A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA. go.json http://purl.obolibrary.org/obo/GO_0140764 GO:0140763 biolink:BiologicalProcess programmed DNA elimination by elimination of internal DNA segments A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates. go.json http://purl.obolibrary.org/obo/GO_0140763 GO:0140766 biolink:BiologicalProcess siRNA-mediated post-transcriptional gene silencing A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants. go.json gene silencing by siRNA|post-transcriptional gene silencing by siRNA|posttranscriptional gene silencing by siRNA|siRNA-mediated PTGS|siRNA-mediated gene silencing http://purl.obolibrary.org/obo/GO_0140766 GO:0140765 biolink:MolecularActivity NAD-dependent histone H3K56 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + H2O = histone H3 L-lysine (position 56) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 56 of the histone H3 protein. go.json NAD-dependent histone H3-K56 deacetylase activity|NAD-dependent histone deacetylase activity (H3-K56 specific) http://purl.obolibrary.org/obo/GO_0140765 GO:0140768 biolink:MolecularActivity protein ADP-ribosyltransferase-substrate adaptor activity An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate. go.json http://purl.obolibrary.org/obo/GO_0140768 GO:0140767 biolink:MolecularActivity enzyme-substrate adaptor activity An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity. go.json protein substrate chaperone activity|protein-substrate adaptor activity http://purl.obolibrary.org/obo/GO_0140767 GO:0140769 biolink:MolecularActivity ACP-dependent peptidyl-lysine N6-myristoyltransferase activity Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]. RHEA:70611 go.json http://purl.obolibrary.org/obo/GO_0140769 GO:0140760 biolink:MolecularActivity histone H3K56me2/H3K56me3 demethylase activity Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein. go.json histone H3-tri/dimethyl-lysine-56 demethylase activity|histone H3K56me2 demethylase activity|histone H3K56me3 demethylase activity|histone demethylase activity (H3-K56 specific) http://purl.obolibrary.org/obo/GO_0140760 GO:0140762 biolink:MolecularActivity glucose dehydrogenase (FAD, quinone) activity Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone. EC:1.1.5.9|MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN|RHEA:47372 go.json http://purl.obolibrary.org/obo/GO_0140762 GO:0140761 biolink:MolecularActivity calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin. go.json calcium- and calmodulin-regulated 3',5'-cyclic-AMP phosphodiesterase activity|calcium- and calmodulin-regulated AMP-specific phosphodiesterase activity|calcium- and calmodulin-regulated cAMP phosphodiesterase activity|calcium- and calmodulin-regulated cyclic-AMP phosphodiesterase activity|calcium/calmodulin-regulated cAMP-specific phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0140761 GO:0140753 biolink:MolecularActivity linear 1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1). go.json http://purl.obolibrary.org/obo/GO_0140753 GO:0140752 biolink:MolecularActivity branched 1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1). go.json http://purl.obolibrary.org/obo/GO_0140752 GO:0140755 biolink:BiologicalProcess reorganization of host cellular membranes to establish sites of replication A process in which a virus triggers host intracellular membranes to be reorganized, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus. go.json http://purl.obolibrary.org/obo/GO_0140755 GO:0140754 biolink:BiologicalProcess reorganization of cellular membranes to establish viral sites of replication A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus. go.json http://purl.obolibrary.org/obo/GO_0140754 GO:0140757 biolink:MolecularActivity cysteine-type deNEDDylase activity An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. go.json http://purl.obolibrary.org/obo/GO_0140757 GO:0140756 biolink:MolecularActivity structural constituent of proteasome The action of a molecule that contributes to the structural integrity of the proteasome. go.json http://purl.obolibrary.org/obo/GO_0140756 GO:0140759 biolink:MolecularActivity histone H3K56 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein. go.json histone H3K56 methylase activity|histone lysine N-methyltransferase activity (H3-K56 specific)|histone methyltransferase activity (H3-K56 specific)|histone-H3K56 methyltransferase activity http://purl.obolibrary.org/obo/GO_0140759 GO:0140758 biolink:MolecularActivity metal-dependent deNEDDylase activity An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. go.json http://purl.obolibrary.org/obo/GO_0140758 GO:0140751 biolink:MolecularActivity histone octamer slider activity A chromatin remodeler activity that slides core histone octamers along chromosomal DNA. go.json histone octamer sliding activity http://purl.obolibrary.org/obo/GO_0140751 GO:0140750 biolink:MolecularActivity nucleosome array spacer activity A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair. go.json nucleosome array spacing activity http://purl.obolibrary.org/obo/GO_0140750 GO:0140706 biolink:BiologicalProcess protein-containing complex localization to centriolar satellite A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite. go.json http://purl.obolibrary.org/obo/GO_0140706 GO:0140708 biolink:BiologicalProcess CAT tailing The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control sytem. go.json http://purl.obolibrary.org/obo/GO_0140708 GO:0140707 biolink:MolecularActivity chromatin-nuclear membrane anchor activity Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis. go.json http://purl.obolibrary.org/obo/GO_0140707 GO:0140709 biolink:BiologicalProcess Frizzled Nuclear Import pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by internalization and cleavage of the frizzled receptor to yeild a C-terminal fragment that is imported into the nucleus. The frizzled C-terminal fragment is incorporated into large ribonucleoprotein particles and stimulates their egress via nuclear budding. go.json FNI|Frizzled Nuclear Import Wnt Pathway http://purl.obolibrary.org/obo/GO_0140709 GO:0042200 biolink:BiologicalProcess cyanuric acid catabolic process The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides. UM-BBD_pathwayID:cya go.json cyanuric acid breakdown|cyanuric acid catabolism|cyanuric acid degradation http://purl.obolibrary.org/obo/GO_0042200 GO:0042202 biolink:BiologicalProcess N-cyclopropylmelamine catabolic process The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide. UM-BBD_pathwayID:cpm go.json N-cyclopropylmelamine breakdown|N-cyclopropylmelamine catabolism|N-cyclopropylmelamine degradation|cyromazine catabolic process|cyromazine catabolism http://purl.obolibrary.org/obo/GO_0042202 GO:0140700 biolink:MolecularActivity 3',2'-cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP). go.json 3',2' cyclic-GMP-AMP synthase activity|3',2'-cyclic GAMP synthase activity http://purl.obolibrary.org/obo/GO_0140700 GO:0042201 biolink:BiologicalProcess N-cyclopropylmelamine metabolic process The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide. go.json N-cyclopropylmelamine metabolism|cyromazine metabolic process|cyromazine metabolism http://purl.obolibrary.org/obo/GO_0042201 GO:0140702 biolink:MolecularActivity cyclic GMP-AMP binding Binding to cyclic GMP-AMP (cGAMP) nucleotide. go.json http://purl.obolibrary.org/obo/GO_0140702 gocheck_do_not_annotate GO:0140701 biolink:MolecularActivity 3',3'-cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP). RHEA:35647 go.json 3',3' cyclic-GAMP synthase activity|3',3' cyclic-GMP-AMP synthase activity|3',3'-cyclic GAMP synthase activity http://purl.obolibrary.org/obo/GO_0140701 GO:0140704 biolink:MolecularActivity 3',2'-cyclic GMP-AMP binding Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages. go.json 3',2' cyclic-GMP-AMP binding|3',2'-cGAMP binding|3',2'-cyclic GAMP binding http://purl.obolibrary.org/obo/GO_0140704 GO:0140703 biolink:MolecularActivity 3',3'-cyclic GMP-AMP binding Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages. go.json 3',3' cyclic-GMP-AMP binding|3',3'-cGAMP binding|3',3'-cGMP-AMP binding|3',3'-cyclic GAMP binding http://purl.obolibrary.org/obo/GO_0140703 GO:0042208 biolink:BiologicalProcess propylene catabolic process The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. UM-BBD_pathwayID:pro go.json propylene breakdown|propylene catabolism|propylene degradation http://purl.obolibrary.org/obo/GO_0042208 GO:0042207 biolink:BiologicalProcess styrene catabolic process The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene. UM-BBD_pathwayID:sty go.json styrene breakdown|styrene catabolism|styrene degradation http://purl.obolibrary.org/obo/GO_0042207 GO:0042209 biolink:BiologicalProcess orcinol catabolic process The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. UM-BBD_pathwayID:orc go.json orcin catabolic process|orcin catabolism|orcinol breakdown|orcinol catabolism|orcinol degradation http://purl.obolibrary.org/obo/GO_0042209 GO:0042204 biolink:BiologicalProcess s-triazine compound catabolic process The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. UM-BBD_pathwayID:tria go.json s-triazine compound breakdown|s-triazine compound catabolism|s-triazine compound degradation http://purl.obolibrary.org/obo/GO_0042204 GO:0042203 biolink:BiologicalProcess toluene catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. go.json toluene breakdown|toluene catabolism|toluene degradation http://purl.obolibrary.org/obo/GO_0042203 GO:0042206 biolink:BiologicalProcess halogenated hydrocarbon catabolic process The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. go.json halogenated hydrocarbon breakdown|halogenated hydrocarbon catabolism|halogenated hydrocarbon degradation http://purl.obolibrary.org/obo/GO_0042206 GO:0042205 biolink:BiologicalProcess chlorinated hydrocarbon catabolic process The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms. go.json chlorinated hydrocarbon breakdown|chlorinated hydrocarbon catabolism|chlorinated hydrocarbon degradation http://purl.obolibrary.org/obo/GO_0042205 GO:0042211 biolink:BiologicalProcess dimethylsilanediol catabolic process The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. go.json catabolic process of DMSD|catabolism of DMSD|degradation of dimethylsilanediol|dimethylsilanediol breakdown|dimethylsilanediol catabolism|dimethylsilanediol degradation http://purl.obolibrary.org/obo/GO_0042211 GO:0042210 biolink:BiologicalProcess octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter. UM-BBD_pathwayID:osi go.json catabolic process of octamethylcyclotetrasiloxane to DMSD|catabolism of octamethylcyclotetrasiloxane to DMSD|octamethylcyclotetrasiloxane breakdown to dimethylsilanediol|octamethylcyclotetrasiloxane degradation to dimethylsilanediol http://purl.obolibrary.org/obo/GO_0042210 GO:0042213 biolink:BiologicalProcess m-cresol catabolic process The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol. MetaCyc:M-CRESOL-DEGRADATION-PWY|UM-BBD_pathwayID:mcr go.json 3-hydroxytoluene catabolic process|3-hydroxytoluene catabolism|m-cresol breakdown|m-cresol catabolism|m-cresol degradation|meta-cresol catabolic process|meta-cresol catabolism http://purl.obolibrary.org/obo/GO_0042213 GO:0042212 biolink:BiologicalProcess cresol metabolic process The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. go.json cresol metabolism|hydroxytoluene metabolic process|hydroxytoluene metabolism http://purl.obolibrary.org/obo/GO_0042212 GO:0042219 biolink:BiologicalProcess cellular modified amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. go.json amino acid derivative catabolic process|cellular amino acid derivative breakdown|cellular amino acid derivative catabolic process|cellular amino acid derivative catabolism|cellular amino acid derivative degradation|cellular modified amino acid breakdown|cellular modified amino acid catabolism|cellular modified amino acid degradation|modified amino acid catabolic process|modified amino acid catabolism http://purl.obolibrary.org/obo/GO_0042219 GO:0042218 biolink:BiologicalProcess 1-aminocyclopropane-1-carboxylate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. go.json 1-aminocyclopropane-1-carboxylate anabolism|1-aminocyclopropane-1-carboxylate biosynthesis|1-aminocyclopropane-1-carboxylate formation|1-aminocyclopropane-1-carboxylate synthesis http://purl.obolibrary.org/obo/GO_0042218 GO:0042215 biolink:BiologicalProcess anaerobic phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. UM-BBD_pathwayID:phe go.json anaerobic phenol-containing compound metabolism http://purl.obolibrary.org/obo/GO_0042215 GO:0042214 biolink:BiologicalProcess terpene metabolic process The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups. go.json terpene metabolism http://purl.obolibrary.org/obo/GO_0042214 GO:0042217 biolink:BiologicalProcess 1-aminocyclopropane-1-carboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. go.json 1-aminocyclopropane-1-carboxylate breakdown|1-aminocyclopropane-1-carboxylate catabolism|1-aminocyclopropane-1-carboxylate degradation http://purl.obolibrary.org/obo/GO_0042217 GO:0042216 biolink:BiologicalProcess phenanthrene catabolic process The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon. UM-BBD_pathwayID:phe go.json phenanthrene breakdown|phenanthrene catabolism|phenanthrene degradation http://purl.obolibrary.org/obo/GO_0042216 GO:0140728 biolink:MolecularActivity GC-box binding Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site. go.json GC box binding|GC rich promoter region binding|GC-rich region binding|GC_rich_promoter_region binding http://purl.obolibrary.org/obo/GO_0140728 GO:0140727 biolink:BiologicalProcess siRNA-dependent pericentric heterochromatin formation The formation of pericentric heterochromatin by a process mediated by a small interfering RNA. go.json RNAi-mediated heterochromatin assembly at centromere|siRNA dependent pericentric heterochromatin assembly|siRNA-dependent pericentric heterochromatin assembly http://purl.obolibrary.org/obo/GO_0140727 GO:0140729 biolink:BiologicalProcess self-resistance to endogenously produced metabolite A process that reduces or removes the toxicity of an endogenously produced substance. Mechanisms of resistance to endogenously produced compounds include modification the compound, export, sequestration, or mutations in the target enzyme. go.json prevention of self-toxicity|self-resistance to bioactive secondary metabolite|self-resistance to endogenously produced compound|self-resistance to endogenously produced toxin http://purl.obolibrary.org/obo/GO_0140729 GO:0140720 biolink:CellularComponent subtelomeric heterochromatin Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). go.json http://purl.obolibrary.org/obo/GO_0140720 GO:0042222 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042222 GO:0042221 biolink:BiologicalProcess response to chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. go.json response to chemical stimulus|response to chemical substance http://purl.obolibrary.org/obo/GO_0042221 gocheck_do_not_manually_annotate|goslim_candida|goslim_drosophila|goslim_metagenomics|goslim_plant|goslim_yeast GO:0140722 biolink:BiologicalProcess mycophenolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of mycophenolic acid (MPA). MPA is the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893. go.json MPA anabolism|MPA biosynthesis|MPA formation|MPA synthesis|mycophenolic acid anabolism|mycophenolic acid biosynthesis|mycophenolic acid formation|mycophenolic acid synthesis http://purl.obolibrary.org/obo/GO_0140722 GO:0042224 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042224 GO:0140721 biolink:MolecularActivity nuclease inhibitor activity Binds to and modulates the activity of a nuclease. go.json http://purl.obolibrary.org/obo/GO_0140721 GO:0042223 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042223 GO:0140724 biolink:BiologicalProcess positive regulation of patulin biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of patulin. go.json positive regulation of patulin anabolism|positive regulation of patulin formation|positive regulation of patulin synthesis http://purl.obolibrary.org/obo/GO_0140724 GO:0140723 biolink:BiologicalProcess patulin biosynthetic process The chemical reactions and pathways resulting in the formation of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. go.json patulin anabolism|patulin biosynthesis|patulin formation|patulin synthesis http://purl.obolibrary.org/obo/GO_0140723 GO:0042220 biolink:BiologicalProcess response to cocaine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. go.json http://purl.obolibrary.org/obo/GO_0042220 GO:0140725 biolink:BiologicalProcess detoxification of free heme Any process that reduces or removes the toxicity of free heme. These include transport of heme away from sensitive areas and to compartments or complexes whose purpose is sequestration of heme. go.json free heme detoxification http://purl.obolibrary.org/obo/GO_0140725 GO:0042229 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042229 GO:0042226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042226 GO:0042225 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042225 GO:0042228 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042228 GO:0042227 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042227 GO:0140717 biolink:BiologicalProcess entry into host through the stromata Entry of a symbiont into host plant tissue via the stromata, microscopic pores in the epidermis of the aerial parts of terrestrial plants. These pores are essential for photosynthesis, as they allow CO2 to diffuse into the plant. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json http://purl.obolibrary.org/obo/GO_0140717 GO:0140719 biolink:BiologicalProcess constitutive heterochromatin formation The compaction of chromatin into a conformation that is refactory to transcription. go.json constitutive heterochromatin assembly http://purl.obolibrary.org/obo/GO_0140719 GO:0140718 biolink:BiologicalProcess facultative heterochromatin formation The compaction of chromatin into a conformation that is refactory to transcription but that be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). go.json fHC assembly|facultative heterochromatin assembly http://purl.obolibrary.org/obo/GO_0140718 GO:0042233 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042233 GO:0042232 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042232 GO:0140711 biolink:BiologicalProcess positive regulation of Frizzled Nuclear Import pathway Any process that activates or increases the frequency, rate or extent of a Frizzled Nuclear Import pathway. go.json positive regulation of FNI|positive regulation of Frizzled Nuclear Import Wnt Pathway http://purl.obolibrary.org/obo/GO_0140711 GO:0042235 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042235 GO:0140710 biolink:BiologicalProcess regulation of Frizzled Nuclear Import pathway Any process that modulates the frequency, rate or extent of a Frizzled Nuclear Import pathway. go.json regulation of FNI|regulation of Frizzled Nuclear Import Wnt Pathway http://purl.obolibrary.org/obo/GO_0140710 GO:0042234 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042234 GO:0140713 biolink:MolecularActivity histone chaperone activity Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone). Reactome:R-HSA-9822185 go.json histone carrier activity|nucleosome remodeling activity http://purl.obolibrary.org/obo/GO_0140713 GO:0140712 biolink:BiologicalProcess negative regulation of Frizzled Nuclear Import pathway Any process that stops, prevents, or reduces the frequency, rate or extent of a Frizzled Nuclear Import pathway. go.json negative regulation of FNI|negative regulation of Frizzled Nuclear Import Wnt Pathway http://purl.obolibrary.org/obo/GO_0140712 GO:0140715 biolink:CellularComponent serine-tRNA ligase complex A heterodimeric enzyme complex that catalyzes the ligation of serine to tRNA(Ser), forming L-seryl-tRNA(Ser). go.json http://purl.obolibrary.org/obo/GO_0140715 GO:0042231 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042231 GO:0042230 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042230 GO:0140714 biolink:CellularComponent large ribosomal subunit pre-assembly complex A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae). go.json http://purl.obolibrary.org/obo/GO_0140714 GO:0042237 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042237 GO:0042236 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042236 GO:0042239 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042239 GO:0042238 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042238 GO:0150156 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150156 GO:0150155 biolink:BiologicalProcess interleukin-34 production The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0150155 gocheck_do_not_annotate GO:0150154 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150154 GO:0150153 biolink:BiologicalProcess positive regulation of interleukin-17A production Any process that activates or increases the frequency, rate or extent of interleukin-17A production. go.json positive regulation of interleukin-17A biosynthetic process http://purl.obolibrary.org/obo/GO_0150153 GO:0150152 biolink:BiologicalProcess negative regulation of interleukin-17A production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production. go.json negative regulation of interleukin-17A biosynthetic process http://purl.obolibrary.org/obo/GO_0150152 GO:0150151 biolink:BiologicalProcess regulation of interleukin-17A production Any process that modulates the frequency, rate or extent of interleukin-17A production. go.json regulation of interleukin-17A biosynthetic process http://purl.obolibrary.org/obo/GO_0150151 GO:0150150 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150150 GO:0150159 biolink:BiologicalProcess negative regulation of interleukin-34 production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production. go.json negative regulation of interleukin-34 biosynthetic process http://purl.obolibrary.org/obo/GO_0150159 GO:0150158 biolink:BiologicalProcess positive regulation of interleukin-34 production Any process that activates or increases the frequency, rate or extent of interleukin-34 production. go.json positive regulation of interleukin-34 biosynthetic process http://purl.obolibrary.org/obo/GO_0150158 GO:0150157 biolink:BiologicalProcess regulation of interleukin-34 production Any process that modulates the frequency, rate or extent of interleukin-34 production. go.json interleukin-34 biosynthetic process|regulation of interleukin-34 biosynthetic process http://purl.obolibrary.org/obo/GO_0150157 GO:0150167 biolink:BiologicalProcess obsolete positive regulation of histone H3-K4 acetylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K4 acetylation. go.json True http://purl.obolibrary.org/obo/GO_0150167 GO:0150166 biolink:BiologicalProcess obsolete regulation of histone H3-K4 acetylation OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K4 acetylation. go.json True http://purl.obolibrary.org/obo/GO_0150166 GO:0150165 biolink:BiologicalProcess obsolete miRNA-mediated inhibition of transcription by RNA polymerase II OBSOLETE. Any process mediated by a microRNA (miRNA) that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0150165 GO:0150164 biolink:BiologicalProcess obsolete miRNA-mediated regulation of transcription by RNA polymerase II OBSOLETE. Any process mediated by a microRNA (miRNA) that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0150164 GO:0150163 biolink:BiologicalProcess obsolete miRNA-mediated activation of transcription by RNA polymerase II OBSOLETE. Any process mediated by a microRNA (miRNA) that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_0150163 GO:0150162 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150162 GO:0150161 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150161 GO:0150160 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150160 GO:0150169 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150169 GO:0150168 biolink:BiologicalProcess obsolete negative regulation of histone H3-K4 acetylation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 acetylation. go.json True http://purl.obolibrary.org/obo/GO_0150168 GO:0150134 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150134 GO:0150133 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150133 GO:0150132 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150132 GO:0150131 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150131 GO:0150130 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150130 GO:0150139 biolink:BiologicalProcess positive regulation of interleukin-37 production Any process that activates or increases the frequency, rate or extent of interleukin-37 production. go.json positive regulation of interleukin-37 biosynthetic process http://purl.obolibrary.org/obo/GO_0150139 GO:0150138 biolink:BiologicalProcess negative regulation of interleukin-37 production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production. go.json negative regulation of interleukin-37 biosynthetic process http://purl.obolibrary.org/obo/GO_0150138 GO:0150137 biolink:BiologicalProcess interleukin-37 production The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json interleukin-37 biosynthetic process http://purl.obolibrary.org/obo/GO_0150137 gocheck_do_not_annotate GO:0150136 biolink:BiologicalProcess regulation of interleukin-37 production Any process that modulates the frequency, rate or extent of interleukin-37 production. go.json regulation of interleukin-37 biosynthetic process http://purl.obolibrary.org/obo/GO_0150136 GO:0150135 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150135 GO:0150145 biolink:BiologicalProcess positive regulation of CD80 production Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process. go.json positive regulation of CD80 biosynthetic process http://purl.obolibrary.org/obo/GO_0150145 GO:0150144 biolink:BiologicalProcess negative regulation of CD80 production Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process. go.json negative regulation of CD80 biosynthetic process http://purl.obolibrary.org/obo/GO_0150144 GO:0150143 biolink:BiologicalProcess regulation of CD80 production Any process that modulates the frequency, rate or extent of CD80 biosynthetic process. go.json regulation of CD80 biosynthetic process http://purl.obolibrary.org/obo/GO_0150143 GO:0150142 biolink:BiologicalProcess positive regulation of CD86 production Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process. go.json positive regulation of CD86 biosynthetic process http://purl.obolibrary.org/obo/GO_0150142 GO:0150141 biolink:BiologicalProcess negative regulation of CD86 production Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process. go.json negative regulation of CD86 biosynthetic process http://purl.obolibrary.org/obo/GO_0150141 GO:0150140 biolink:BiologicalProcess regulation of CD86 production Any process that modulates the frequency, rate or extent of CD86 biosynthetic process. go.json regulation of CD86 biosynthetic process http://purl.obolibrary.org/obo/GO_0150140 GO:0150149 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150149 GO:0150148 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150148 GO:0150147 biolink:BiologicalProcess cell-cell junction disassembly The disaggregation of a cell-cell junction into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0150147 GO:0150146 biolink:BiologicalProcess cell junction disassembly The disaggregation of a cell junction into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0150146 GO:0140786 biolink:MolecularActivity glutamine sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine. go.json glutamine sensing activity http://purl.obolibrary.org/obo/GO_0140786 GO:0150112 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150112 GO:0150111 biolink:BiologicalProcess regulation of transepithelial transport Any process that modulates the frequency, rate or extent of transepithelial transport. go.json http://purl.obolibrary.org/obo/GO_0150111 GO:0140785 biolink:MolecularActivity amino acid sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid. go.json amino acid sensing activity http://purl.obolibrary.org/obo/GO_0140785 GO:0140788 biolink:MolecularActivity L-glutamate uniporter activity Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. RHEA:66336 go.json glutamate uniporter activity http://purl.obolibrary.org/obo/GO_0140788 GO:0150110 biolink:BiologicalProcess obsolete negative regulation of cholesterol esterification OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification. go.json True http://purl.obolibrary.org/obo/GO_0150110 GO:0140787 biolink:MolecularActivity phosphate ion uniporter activity Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. go.json http://purl.obolibrary.org/obo/GO_0140787 GO:0140789 biolink:MolecularActivity histone phosphatase activity Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate. go.json http://purl.obolibrary.org/obo/GO_0140789 GO:0150119 biolink:BiologicalProcess negative regulation of protein localization to cell-cell junction Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. go.json negative regulation of protein localisation to cell-cell junction http://purl.obolibrary.org/obo/GO_0150119 GO:0140780 biolink:BiologicalProcess obsolete modulation by symbiont of host system process OBSOLETE. The process in which a symbiont organism effects a change in an anatomical system process of its host organism. go.json True http://purl.obolibrary.org/obo/GO_0140780 GO:0150118 biolink:BiologicalProcess negative regulation of cell-substrate junction organization Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization. go.json http://purl.obolibrary.org/obo/GO_0150118 GO:0150117 biolink:BiologicalProcess positive regulation of cell-substrate junction organization Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization. go.json http://purl.obolibrary.org/obo/GO_0150117 GO:0150116 biolink:BiologicalProcess regulation of cell-substrate junction organization Any process that modulates the frequency, rate or extent of cell-substrate junction organization. go.json http://purl.obolibrary.org/obo/GO_0150116 GO:0140782 biolink:BiologicalProcess novofumigatonin biosynthetic process The chemical reactions and pathways resulting in the formation of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. go.json novofumigatonin anabolism|novofumigatonin biosynthesis|novofumigatonin formation|novofumigatonin synthesis http://purl.obolibrary.org/obo/GO_0140782 GO:0140781 biolink:BiologicalProcess ilicicolin H biosynthetic process The chemical reactions and pathways resulting in the formation of ilicicolin H, a 4-hydroxy-2-pyridone alkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. go.json ilicicolin H anabolism|ilicicolin H biosynthesis|ilicicolin H formation|ilicicolin H synthesis http://purl.obolibrary.org/obo/GO_0140781 GO:0150115 biolink:BiologicalProcess cell-substrate junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0150115 GO:0150114 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150114 GO:0140784 biolink:MolecularActivity metal ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion. go.json http://purl.obolibrary.org/obo/GO_0140784 GO:0140783 biolink:BiologicalProcess (M)-viriditoxin biosynthetic process The chemical reactions and pathways resulting in the formation of (M)-viriditoxin, a fungal secondary metabolite with antibacterial activity. go.json (M)-viriditoxin anabolism|(M)-viriditoxin biosynthesis|(M)-viriditoxin formation|(M)-viriditoxin synthesis|viriditoxin anabolism|viriditoxin biosynthesis|viriditoxin formation|viriditoxin synthesis http://purl.obolibrary.org/obo/GO_0140783 GO:0150113 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150113 GO:0140775 biolink:MolecularActivity actin filament debranching activity Binding to an actin filament and promoting the dissociation of an actin filament branch. go.json actin debranching activity http://purl.obolibrary.org/obo/GO_0140775 GO:0150123 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150123 GO:0140774 biolink:MolecularActivity NAD-dependent protein depalmitoylase activity Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:70563 go.json http://purl.obolibrary.org/obo/GO_0140774 GO:0150122 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150122 GO:0150121 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150121 GO:0140777 biolink:MolecularActivity protein-containing complex stabilizing activity A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex. go.json http://purl.obolibrary.org/obo/GO_0140777 GO:0140776 biolink:MolecularActivity protein-containing complex destabilizing activity A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex. go.json protein unfoldase activity http://purl.obolibrary.org/obo/GO_0140776 GO:0150120 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150120 GO:0140779 biolink:BiologicalProcess XCL1 production The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Wikipedia:XCL1 go.json lymphotactin production http://purl.obolibrary.org/obo/GO_0140779 gocheck_do_not_annotate GO:0140778 biolink:MolecularActivity microtubule stabilizing activity A protein-containing complex stabilizing activity that prevents dissociation of microtubules. go.json http://purl.obolibrary.org/obo/GO_0140778 GO:0150129 biolink:BiologicalProcess positive regulation of interleukin-33 production Any process that activates or increases the frequency, rate or extent of interleukin-33 production. go.json positive regulation of interleukin-33 biosynthetic process|positive regulation of interleukin-33 secretion http://purl.obolibrary.org/obo/GO_0150129 GO:0150128 biolink:BiologicalProcess negative regulation of interleukin-33 production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production. go.json negative regulation of interleukin-33 biosynthetic process|negative regulation of interleukin-33 secretion http://purl.obolibrary.org/obo/GO_0150128 GO:0150127 biolink:BiologicalProcess regulation of interleukin-33 production Any process that modulates the frequency, rate or extent of interleukin-33 production. go.json regulation of interleukin-33 biosynthetic process|regulation of interleukin-33 secretion http://purl.obolibrary.org/obo/GO_0150127 GO:0140771 biolink:MolecularActivity ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]. RHEA:70615 go.json http://purl.obolibrary.org/obo/GO_0140771 GO:0140770 biolink:MolecularActivity CoA-dependent peptidyl-lysine N6-myristoyltransferase activity Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein]. RHEA:59752 go.json http://purl.obolibrary.org/obo/GO_0140770 GO:0150126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150126 GO:0150125 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150125 GO:0140773 biolink:MolecularActivity NAD-dependent protein demyristoylase activity Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. RHEA:70567 go.json http://purl.obolibrary.org/obo/GO_0140773 GO:0140772 biolink:MolecularActivity CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein]. go.json http://purl.obolibrary.org/obo/GO_0140772 GO:0150124 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150124 GO:0140797 biolink:MolecularActivity histone H3R17 arginine deiminase activity Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17. go.json H3-R17 citrullination|histone H3-R17 arginine deiminase activity|histone-arginine deiminase activity (H3-R17 specific) http://purl.obolibrary.org/obo/GO_0140797 GO:0150101 biolink:BiologicalProcess regulation of microtubule anchoring at centrosome Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome. go.json http://purl.obolibrary.org/obo/GO_0150101 GO:0140796 biolink:MolecularActivity histone H3R8 arginine deiminase activity Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8. go.json H3-R8 citrullination|histone H3-R8 arginine deiminase activity|histone-arginine deiminase activity (H3-R8 specific) http://purl.obolibrary.org/obo/GO_0140796 GO:0150100 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150100 GO:0140799 biolink:MolecularActivity glycine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out). go.json http://purl.obolibrary.org/obo/GO_0140799 GO:0140798 biolink:MolecularActivity histone H3R26 arginine deiminase activity Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26. go.json H3-R26 citrullination|histone H3-R26 arginine deiminase activity|histone-arginine deiminase activity (H3-R26 specific) http://purl.obolibrary.org/obo/GO_0140798 GO:0140791 biolink:MolecularActivity histone H2AXS140 phosphatase activity Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate. go.json histone H2-S140 serine phosphatase activity|histone H2S140 phosphatase activity|histone serine phosphatase activity (H2-S140 specific) http://purl.obolibrary.org/obo/GO_0140791 GO:0150107 biolink:BiologicalProcess positive regulation of protein localization to cell-cell junction Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. go.json http://purl.obolibrary.org/obo/GO_0150107 GO:0150106 biolink:BiologicalProcess regulation of protein localization to cell-cell junction Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. go.json http://purl.obolibrary.org/obo/GO_0150106 GO:0140790 biolink:MolecularActivity obsolete histone serine/threonine phosphatase activity OBSOLETE. Catalysis of the reaction: histone serine phosphate + H2O = histone serine + phosphate, and histone threonine phosphate + H2O = histone threonine + phosphate. go.json True http://purl.obolibrary.org/obo/GO_0140790 GO:0140793 biolink:MolecularActivity histone H2AXY142 phosphatase activity Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate. go.json histone H2-Y142 phosphatase activity|histone H2Y142 phosphatase activity|histone tyrosine phosphatase activity (H2-Y142 specific) http://purl.obolibrary.org/obo/GO_0140793 GO:0150105 biolink:BiologicalProcess protein localization to cell-cell junction A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. go.json http://purl.obolibrary.org/obo/GO_0150105 GO:0140792 biolink:MolecularActivity obsolete histone tyrosine phosphatase activity OBSOLETE. Catalysis of the reaction: histone tyrosine phosphate + H2O = histone tyrosine + phosphate. go.json True http://purl.obolibrary.org/obo/GO_0140792 GO:0150104 biolink:BiologicalProcess transport across blood-brain barrier The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. go.json transport across BBB|transport across blood brain barrier http://purl.obolibrary.org/obo/GO_0150104 GO:0140795 biolink:MolecularActivity histone H3R2 arginine deiminase activity Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2. go.json H3-R2 citrullination|histone H3-R2 arginine deiminase activity|histone-arginine deiminase activity (H3-R2 specific) http://purl.obolibrary.org/obo/GO_0140795 GO:0150103 biolink:BiologicalProcess reactive gliosis A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells. go.json gliosis http://purl.obolibrary.org/obo/GO_0150103 GO:0150102 biolink:BiologicalProcess negative regulation of monocyte activation Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation. go.json repression of monocyte activation http://purl.obolibrary.org/obo/GO_0150102 GO:0140794 biolink:MolecularActivity histone arginine deiminase activity Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination. go.json histone citrullination|histone-arginine deiminase activity http://purl.obolibrary.org/obo/GO_0140794 GO:0032838 biolink:CellularComponent plasma membrane bounded cell projection cytoplasm All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. go.json http://purl.obolibrary.org/obo/GO_0032838 GO:0032837 biolink:BiologicalProcess distributive segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally. go.json http://purl.obolibrary.org/obo/GO_0032837 GO:0032836 biolink:BiologicalProcess glomerular basement membrane development The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. go.json http://purl.obolibrary.org/obo/GO_0032836 GO:0032835 biolink:BiologicalProcess glomerulus development The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. go.json glomerular development http://purl.obolibrary.org/obo/GO_0032835 GO:0032834 biolink:BiologicalProcess positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. go.json activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response|stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0032834 GO:0032833 biolink:BiologicalProcess negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. go.json down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0032833 GO:0032832 biolink:BiologicalProcess regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. go.json regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response http://purl.obolibrary.org/obo/GO_0032832 GO:0032831 biolink:BiologicalProcess positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. go.json activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation|stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation http://purl.obolibrary.org/obo/GO_0032831 GO:0032839 biolink:CellularComponent dendrite cytoplasm All of the contents of a dendrite, excluding the surrounding plasma membrane. go.json dendritic cytoplasm http://purl.obolibrary.org/obo/GO_0032839 GO:0032830 biolink:BiologicalProcess negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. go.json down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0032830 GO:0032827 biolink:BiologicalProcess negative regulation of natural killer cell differentiation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response. go.json down regulation of natural killer cell differentiation during immune response|down-regulation of natural killer cell differentiation during immune response|downregulation of natural killer cell differentiation during immune response|inhibition of natural killer cell differentiation during immune response|negative regulation of NK cell differentiation during immune response|negative regulation of natural killer cell development involved in immune response|negative regulation of natural killer cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0032827 GO:0032826 biolink:BiologicalProcess regulation of natural killer cell differentiation involved in immune response Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response. go.json regulation of NK cell differentiation during immune response|regulation of natural killer cell development involved in immune response|regulation of natural killer cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0032826 GO:0032825 biolink:BiologicalProcess positive regulation of natural killer cell differentiation Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation. go.json activation of natural killer cell differentiation|positive regulation of NK cell differentiation|positive regulation of natural killer cell development|stimulation of natural killer cell differentiation|up regulation of natural killer cell differentiation|up-regulation of natural killer cell differentiation|upregulation of natural killer cell differentiation http://purl.obolibrary.org/obo/GO_0032825 GO:0032824 biolink:BiologicalProcess negative regulation of natural killer cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation. go.json down regulation of natural killer cell differentiation|down-regulation of natural killer cell differentiation|downregulation of natural killer cell differentiation|inhibition of natural killer cell differentiation|negative regulation of NK cell differentiation|negative regulation of natural killer cell development http://purl.obolibrary.org/obo/GO_0032824 GO:0032823 biolink:BiologicalProcess regulation of natural killer cell differentiation Any process that modulates the frequency, rate or extent of natural killer cell differentiation. go.json regulation of NK cell differentiation|regulation of natural killer cell development http://purl.obolibrary.org/obo/GO_0032823 GO:0032822 biolink:BiologicalProcess positive regulation of natural killer cell proliferation involved in immune response Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response. go.json activation of natural killer cell proliferation during immune response|positive regulation of NK cell proliferation during immune response|positive regulation of natural killer cell proliferation during immune response|stimulation of natural killer cell proliferation during immune response|up regulation of natural killer cell proliferation during immune response|up-regulation of natural killer cell proliferation during immune response|upregulation of natural killer cell proliferation during immune response http://purl.obolibrary.org/obo/GO_0032822 GO:0032821 biolink:BiologicalProcess negative regulation of natural killer cell proliferation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response. go.json down regulation of natural killer cell proliferation during immune response|down-regulation of natural killer cell proliferation during immune response|downregulation of natural killer cell proliferation during immune response|inhibition of natural killer cell proliferation during immune response|negative regulation of NK cell proliferation during immune response|negative regulation of natural killer cell proliferation during immune response http://purl.obolibrary.org/obo/GO_0032821 GO:0032820 biolink:BiologicalProcess regulation of natural killer cell proliferation involved in immune response Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response. go.json regulation of NK cell proliferation during immune response|regulation of natural killer cell proliferation during immune response http://purl.obolibrary.org/obo/GO_0032820 GO:0032829 biolink:BiologicalProcess regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. go.json regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0032829 GO:0032828 biolink:BiologicalProcess positive regulation of natural killer cell differentiation involved in immune response Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response. go.json activation of natural killer cell differentiation during immune response|positive regulation of NK cell differentiation during immune response|positive regulation of natural killer cell development involved in immune response|positive regulation of natural killer cell differentiation during immune response|stimulation of natural killer cell differentiation during immune response|up regulation of natural killer cell differentiation during immune response|up-regulation of natural killer cell differentiation during immune response|upregulation of natural killer cell differentiation during immune response http://purl.obolibrary.org/obo/GO_0032828 GO:0032816 biolink:BiologicalProcess positive regulation of natural killer cell activation Any process that activates or increases the frequency, rate or extent of natural killer cell activation. go.json activation of natural killer cell activation|positive regulation of NK cell activation|stimulation of natural killer cell activation|up regulation of natural killer cell activation|up-regulation of natural killer cell activation|upregulation of natural killer cell activation http://purl.obolibrary.org/obo/GO_0032816 GO:0032815 biolink:BiologicalProcess negative regulation of natural killer cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. go.json down regulation of natural killer cell activation|down-regulation of natural killer cell activation|downregulation of natural killer cell activation|inhibition of natural killer cell activation|negative regulation of NK cell activation http://purl.obolibrary.org/obo/GO_0032815 GO:0032814 biolink:BiologicalProcess regulation of natural killer cell activation Any process that modulates the frequency, rate or extent of natural killer cell activation. go.json regulation of NK cell activation http://purl.obolibrary.org/obo/GO_0032814 GO:0032813 biolink:MolecularActivity tumor necrosis factor receptor superfamily binding Binding to a member of the tumor necrosis factor receptor superfamily. go.json TNF receptor superfamily binding http://purl.obolibrary.org/obo/GO_0032813 GO:0032812 biolink:BiologicalProcess positive regulation of epinephrine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine. go.json activation of epinephrine secretion|positive regulation of adrenaline secretion|stimulation of epinephrine secretion|up regulation of epinephrine secretion|up-regulation of epinephrine secretion|upregulation of epinephrine secretion http://purl.obolibrary.org/obo/GO_0032812 GO:0032811 biolink:BiologicalProcess negative regulation of epinephrine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine. go.json down regulation of epinephrine secretion|down-regulation of epinephrine secretion|downregulation of epinephrine secretion|inhibition of epinephrine secretion|negative regulation of adrenaline secretion http://purl.obolibrary.org/obo/GO_0032811 GO:0032810 biolink:MolecularActivity sterol response element binding Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. go.json SRE binding http://purl.obolibrary.org/obo/GO_0032810 GO:0032819 biolink:BiologicalProcess positive regulation of natural killer cell proliferation Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation. go.json activation of natural killer cell proliferation|positive regulation of NK cell proliferation|stimulation of natural killer cell proliferation|up regulation of natural killer cell proliferation|up-regulation of natural killer cell proliferation|upregulation of natural killer cell proliferation http://purl.obolibrary.org/obo/GO_0032819 GO:0032818 biolink:BiologicalProcess negative regulation of natural killer cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation. go.json down regulation of natural killer cell proliferation|down-regulation of natural killer cell proliferation|downregulation of natural killer cell proliferation|inhibition of natural killer cell proliferation|negative regulation of NK cell proliferation http://purl.obolibrary.org/obo/GO_0032818 GO:0032817 biolink:BiologicalProcess regulation of natural killer cell proliferation Any process that modulates the frequency, rate or extent of natural killer cell proliferation. go.json regulation of NK cell proliferation http://purl.obolibrary.org/obo/GO_0032817 GO:0032805 biolink:BiologicalProcess positive regulation of low-density lipoprotein particle receptor catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors. go.json activation of low-density lipoprotein receptor catabolic process|positive regulation of low-density lipoprotein receptor breakdown|positive regulation of low-density lipoprotein receptor catabolic process|positive regulation of low-density lipoprotein receptor catabolism|positive regulation of low-density lipoprotein receptor degradation|stimulation of low-density lipoprotein receptor catabolic process|up regulation of low-density lipoprotein receptor catabolic process|up-regulation of low-density lipoprotein receptor catabolic process|upregulation of low-density lipoprotein receptor catabolic process http://purl.obolibrary.org/obo/GO_0032805 GO:0032804 biolink:BiologicalProcess negative regulation of low-density lipoprotein particle receptor catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors. go.json down regulation of low-density lipoprotein receptor catabolic process|down-regulation of low-density lipoprotein receptor catabolic process|downregulation of low-density lipoprotein receptor catabolic process|inhibition of low-density lipoprotein receptor catabolic process|negative regulation of low-density lipoprotein receptor breakdown|negative regulation of low-density lipoprotein receptor catabolic process|negative regulation of low-density lipoprotein receptor catabolism|negative regulation of low-density lipoprotein receptor degradation http://purl.obolibrary.org/obo/GO_0032804 GO:0032803 biolink:BiologicalProcess regulation of low-density lipoprotein particle receptor catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors. go.json regulation of LDLr catabolic process|regulation of LDLr catabolism|regulation of low-density lipoprotein receptor breakdown|regulation of low-density lipoprotein receptor catabolic process|regulation of low-density lipoprotein receptor catabolism|regulation of low-density lipoprotein receptor degradation http://purl.obolibrary.org/obo/GO_0032803 GO:0032802 biolink:BiologicalProcess low-density lipoprotein particle receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json LDL receptor breakdown|LDL receptor catabolic process|LDL receptor catabolism|LDL receptor degradation|low-density lipoprotein receptor breakdown|low-density lipoprotein receptor catabolic process|low-density lipoprotein receptor catabolism|low-density lipoprotein receptor degradation http://purl.obolibrary.org/obo/GO_0032802 GO:0032801 biolink:BiologicalProcess receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json receptor breakdown|receptor catabolism|receptor degradation http://purl.obolibrary.org/obo/GO_0032801 GO:0032800 biolink:BiologicalProcess obsolete receptor biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. go.json receptor anabolism|receptor biosynthesis|receptor formation|receptor synthesis True http://purl.obolibrary.org/obo/GO_0032800 GO:0032809 biolink:CellularComponent neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. go.json neuron cell body membrane|neuronal cell soma membrane http://purl.obolibrary.org/obo/GO_0032809 GO:0032808 biolink:BiologicalProcess lacrimal gland development The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. go.json http://purl.obolibrary.org/obo/GO_0032808 GO:0032807 biolink:CellularComponent DNA ligase IV complex A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p. go.json DNA ligase IV-XRCC4 complex http://purl.obolibrary.org/obo/GO_0032807 GO:0032806 biolink:CellularComponent carboxy-terminal domain protein kinase complex A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. go.json CTDK complex http://purl.obolibrary.org/obo/GO_0032806 GO:0150192 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150192 GO:0150191 biolink:BiologicalProcess positive regulation of interleukin-32 production Any process that activates or increases the frequency, rate or extent of interleukin-32 production. go.json positive regulation of interleukin-32 biosynthetic process|positive regulation of interleukin-32 secretion http://purl.obolibrary.org/obo/GO_0150191 GO:0150190 biolink:BiologicalProcess negative regulation of interleukin-32 production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production. go.json negative regulation of interleukin-32 biosynthetic process|negative regulation of interleukin-32 secretion http://purl.obolibrary.org/obo/GO_0150190 GO:0150195 biolink:BiologicalProcess transport across blood-cerebrospinal fluid barrier The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier. go.json transport across BCSFB|transport across blood-CSF barrier|transport across blood/CSF barrier|transport across blood/cerebrospinal fluid barrier http://purl.obolibrary.org/obo/GO_0150195 GO:0150194 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150194 GO:0150193 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150193 GO:0150170 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150170 GO:0150178 biolink:BiologicalProcess regulation of phosphatidylserine metabolic process Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150178 GO:0150177 biolink:BiologicalProcess negative regulation of phosphatidylethanolamine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150177 GO:0150176 biolink:BiologicalProcess positive regulation of phosphatidylethanolamine metabolic process Any process that activates or increases the frequency, rate or extent of phosphatidylethanolamine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150176 GO:0150175 biolink:BiologicalProcess regulation of phosphatidylethanolamine metabolic process Any process that modulates the frequency, rate or extent of phosphatidylethanolamine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150175 GO:0150174 biolink:BiologicalProcess negative regulation of phosphatidylcholine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150174 GO:0150173 biolink:BiologicalProcess positive regulation of phosphatidylcholine metabolic process Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150173 GO:0150172 biolink:BiologicalProcess regulation of phosphatidylcholine metabolic process Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150172 GO:0150171 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150171 GO:0150179 biolink:BiologicalProcess positive regulation of phosphatidylserine metabolic process Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150179 GO:0150180 biolink:BiologicalProcess negative regulation of phosphatidylserine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine metabolic process. go.json http://purl.obolibrary.org/obo/GO_0150180 GO:0150189 biolink:BiologicalProcess regulation of interleukin-32 production Any process that modulates the frequency, rate or extent of interleukin-32 production. go.json regulation of interleukin-32 biosynthetic process|regulation of interleukin-32 secretion http://purl.obolibrary.org/obo/GO_0150189 GO:0150188 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0150188 GO:0042365 biolink:BiologicalProcess water-soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water. go.json water-soluble vitamin breakdown|water-soluble vitamin catabolism|water-soluble vitamin degradation http://purl.obolibrary.org/obo/GO_0042365 GO:0042364 biolink:BiologicalProcess water-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. go.json water-soluble vitamin anabolism|water-soluble vitamin biosynthesis|water-soluble vitamin formation|water-soluble vitamin synthesis http://purl.obolibrary.org/obo/GO_0042364 GO:0042367 biolink:BiologicalProcess biotin catabolic process The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. go.json biotin breakdown|biotin catabolism|biotin degradation|vitamin B7 catabolic process|vitamin B7 catabolism|vitamin H catabolic process|vitamin H catabolism http://purl.obolibrary.org/obo/GO_0042367 GO:0042366 biolink:BiologicalProcess cobalamin catabolic process The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. go.json cobalamin breakdown|cobalamin catabolism|cobalamin degradation|vitamin B12 catabolic process|vitamin B12 catabolism http://purl.obolibrary.org/obo/GO_0042366 GO:0042361 biolink:BiologicalProcess menaquinone catabolic process The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. go.json menaquinone breakdown|menaquinone catabolism|menaquinone degradation|menatetrenone catabolic process|menatetrenone catabolism|multiprenylmenaquinone catabolic process|multiprenylmenaquinone catabolism|vitamin K2 catabolic process|vitamin K2 catabolism http://purl.obolibrary.org/obo/GO_0042361 GO:0042360 biolink:BiologicalProcess vitamin E metabolic process The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. go.json alpha-tocopherol metabolic process|alpha-tocopherol metabolism|tocopherol metabolic process|tocopherol metabolism|vitamin E metabolism http://purl.obolibrary.org/obo/GO_0042360 GO:0042363 biolink:BiologicalProcess fat-soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. go.json fat-soluble vitamin breakdown|fat-soluble vitamin catabolism|fat-soluble vitamin degradation http://purl.obolibrary.org/obo/GO_0042363 GO:0042362 biolink:BiologicalProcess fat-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. go.json fat-soluble vitamin anabolism|fat-soluble vitamin biosynthesis|fat-soluble vitamin formation|fat-soluble vitamin synthesis http://purl.obolibrary.org/obo/GO_0042362 GO:0042369 biolink:BiologicalProcess vitamin D catabolic process The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json calciferol catabolic process|calciferol catabolism|cholecalciferol biosynthesis|cholecalciferol biosynthetic process|ergocalciferol biosynthesis|ergocalciferol biosynthetic process|vitamin D breakdown|vitamin D catabolism|vitamin D degradation http://purl.obolibrary.org/obo/GO_0042369 GO:0042368 biolink:BiologicalProcess vitamin D biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json calciferol biosynthesis|calciferol biosynthetic process|cholecalciferol biosynthesis|cholecalciferol biosynthetic process|ergocalciferol biosynthesis|ergocalciferol biosynthetic process|vitamin D anabolism|vitamin D biosynthesis|vitamin D formation|vitamin D synthesis http://purl.obolibrary.org/obo/GO_0042368 GO:0042370 biolink:BiologicalProcess thiamine diphosphate dephosphorylation The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. go.json TPP dephosphorylation|thiamin diphosphate dephosphorylation http://purl.obolibrary.org/obo/GO_0042370 GO:0042376 biolink:BiologicalProcess phylloquinone catabolic process The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. go.json phylloquinone breakdown|phylloquinone catabolism|phylloquinone degradation|phytomenadione catabolic process|phytomenadione catabolism|phytonadione catabolic process|phytonadione catabolism|phytylmenaquinone catabolic process|phytylmenaquinone catabolism|vitamin K1 catabolic process|vitamin K1 catabolism http://purl.obolibrary.org/obo/GO_0042376 GO:0042375 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042375 GO:0042378 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042378 GO:0042377 biolink:BiologicalProcess vitamin K catabolic process The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. go.json naphthoquinone catabolic process|naphthoquinone catabolism|vitamin K breakdown|vitamin K catabolism|vitamin K degradation http://purl.obolibrary.org/obo/GO_0042377 GO:0042372 biolink:BiologicalProcess phylloquinone biosynthetic process The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. MetaCyc:PWY-5027 go.json phylloquinone anabolism|phylloquinone biosynthesis|phylloquinone formation|phylloquinone synthesis|phytomenadione biosynthesis|phytomenadione biosynthetic process|phytonadione biosynthesis|phytonadione biosynthetic process|phytylmenaquinone biosynthesis|phytylmenaquinone biosynthetic process|vitamin K1 biosynthesis|vitamin K1 biosynthetic process http://purl.obolibrary.org/obo/GO_0042372 GO:0042371 biolink:BiologicalProcess vitamin K biosynthetic process The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. go.json naphthoquinone metabolic process|naphthoquinone metabolism|vitamin K anabolism|vitamin K biosynthesis|vitamin K formation|vitamin K synthesis http://purl.obolibrary.org/obo/GO_0042371 GO:0042374 biolink:BiologicalProcess phylloquinone metabolic process The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1. go.json phylloquinone metabolism|phytomenadione metabolic process|phytomenadione metabolism|phytonadione metabolic process|phytonadione metabolism|phytylmenaquinone metabolic process|phytylmenaquinone metabolism|vitamin K1 metabolic process|vitamin K1 metabolism http://purl.obolibrary.org/obo/GO_0042374 GO:0042373 biolink:BiologicalProcess vitamin K metabolic process The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. go.json naphthoquinone metabolic process|naphthoquinone metabolism|vitamin K metabolism http://purl.obolibrary.org/obo/GO_0042373 GO:0042379 biolink:MolecularActivity chemokine receptor binding Binding to a chemokine receptor. go.json chemokine receptor ligand http://purl.obolibrary.org/obo/GO_0042379 GO:0042381 biolink:BiologicalProcess hemolymph coagulation Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response. go.json hemolymph clotting http://purl.obolibrary.org/obo/GO_0042381 GO:0042380 biolink:MolecularActivity hydroxymethylbutenyl pyrophosphate reductase activity Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate. go.json (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming) http://purl.obolibrary.org/obo/GO_0042380 GO:0042387 biolink:BiologicalProcess plasmatocyte differentiation The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response. go.json http://purl.obolibrary.org/obo/GO_0042387 GO:0042386 biolink:BiologicalProcess hemocyte differentiation The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. go.json arthropod blood cell differentiation http://purl.obolibrary.org/obo/GO_0042386 GO:0042389 biolink:MolecularActivity omega-3 fatty acid desaturase activity Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain. go.json http://purl.obolibrary.org/obo/GO_0042389 GO:0042388 biolink:BiologicalProcess gibberellic acid mediated signaling pathway, G-alpha-dependent The series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. go.json gibberellic acid mediated signalling, G-alpha-dependent http://purl.obolibrary.org/obo/GO_0042388 GO:0042383 biolink:CellularComponent sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. Wikipedia:Sarcolemma go.json http://purl.obolibrary.org/obo/GO_0042383 GO:0042382 biolink:CellularComponent paraspeckles Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. Wikipedia:Paraspeckle go.json http://purl.obolibrary.org/obo/GO_0042382 GO:0042385 biolink:CellularComponent myosin III complex A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain. go.json http://purl.obolibrary.org/obo/GO_0042385 GO:0042384 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042384 GO:0042390 biolink:BiologicalProcess gibberellic acid mediated signaling pathway, G-alpha-independent The series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. go.json gibberellic acid mediated signalling, G-alpha-independent http://purl.obolibrary.org/obo/GO_0042390 GO:0042392 biolink:MolecularActivity sphingosine-1-phosphate phosphatase activity Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. MetaCyc:RXN3DJ-25|RHEA:27518|Reactome:R-HSA-428690|Reactome:R-HSA-428696|Reactome:R-HSA-428701 go.json SPP phosphatase activity|SPPase activity|sphingosine-1-phosphate phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0042392 GO:0042391 biolink:BiologicalProcess regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. go.json http://purl.obolibrary.org/obo/GO_0042391 GO:0042398 biolink:BiologicalProcess cellular modified amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. go.json amino acid derivative biosynthetic process|cellular amino acid derivative anabolism|cellular amino acid derivative biosynthesis|cellular amino acid derivative biosynthetic process|cellular amino acid derivative formation|cellular amino acid derivative synthesis|cellular modified amino acid anabolism|cellular modified amino acid biosynthesis|cellular modified amino acid formation|cellular modified amino acid synthesis http://purl.obolibrary.org/obo/GO_0042398 GO:0042397 biolink:BiologicalProcess phosphagen catabolic process The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. go.json phosphagen breakdown|phosphagen catabolism|phosphagen degradation http://purl.obolibrary.org/obo/GO_0042397 GO:0042399 biolink:BiologicalProcess ectoine metabolic process The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. go.json ectoine metabolism http://purl.obolibrary.org/obo/GO_0042399 GO:0042394 biolink:BiologicalProcess obsolete ecdysis, protein-based cuticle OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates. go.json ecdysis, protein-based cuticle True http://purl.obolibrary.org/obo/GO_0042394 GO:0042393 biolink:MolecularActivity histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. go.json histone-specific chaperone activity http://purl.obolibrary.org/obo/GO_0042393 goslim_chembl|goslim_drosophila|goslim_generic|goslim_yeast|prokaryote_subset GO:0042396 biolink:BiologicalProcess phosphagen biosynthetic process The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. go.json phosphagen anabolism|phosphagen biosynthesis|phosphagen formation|phosphagen synthesis http://purl.obolibrary.org/obo/GO_0042396 GO:0042395 biolink:BiologicalProcess ecdysis, collagen and cuticulin-based cuticle The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates. go.json http://purl.obolibrary.org/obo/GO_0042395 GO:0032999 biolink:CellularComponent Fc-alpha receptor I complex A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA. go.json FcaRI complex|IgA receptor complex|immunoglobulin A receptor complex http://purl.obolibrary.org/obo/GO_0032999 GO:0032998 biolink:CellularComponent Fc-epsilon receptor I complex A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE. go.json FceRI complex|IgE receptor complex|immunoglobulin E receptor complex http://purl.obolibrary.org/obo/GO_0032998 GO:0032997 biolink:CellularComponent Fc receptor complex A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. go.json Fc-receptor complex|FcR complex|immunoglobulin receptor complex http://purl.obolibrary.org/obo/GO_0032997 goslim_pir GO:0032996 biolink:CellularComponent Bcl3-Bcl10 complex A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus. go.json http://purl.obolibrary.org/obo/GO_0032996 GO:0032995 biolink:BiologicalProcess regulation of fungal-type cell wall biogenesis Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin. go.json regulation of chitin- and beta-glucan-containing cell wall biogenesis http://purl.obolibrary.org/obo/GO_0032995 GO:0032994 biolink:CellularComponent protein-lipid complex A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. go.json http://purl.obolibrary.org/obo/GO_0032994 GO:0032993 biolink:CellularComponent protein-DNA complex A macromolecular complex containing both protein and DNA molecules. go.json DNA-protein complex http://purl.obolibrary.org/obo/GO_0032993 goslim_pir GO:0032992 biolink:CellularComponent protein-carbohydrate complex A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other. go.json http://purl.obolibrary.org/obo/GO_0032992 GO:0032991 biolink:CellularComponent protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. go.json macromolecular complex|macromolecule complex|protein complex|protein containing complex|protein-protein complex http://purl.obolibrary.org/obo/GO_0032991 goslim_agr|goslim_chembl|goslim_flybase_ribbon|goslim_mouse|goslim_pir GO:0032990 biolink:BiologicalProcess cell part morphogenesis The process in which the anatomical structures of a cell part are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0032990 GO:0032989 biolink:BiologicalProcess cellular component morphogenesis The process in which cellular structures, including whole cells or cell parts, are generated and organized. go.json cellular structure morphogenesis http://purl.obolibrary.org/obo/GO_0032989 goslim_pir GO:0032988 biolink:BiologicalProcess protein-RNA complex disassembly The disaggregation of a protein-RNA complex into its constituent components. go.json RNA-protein complex disassembly|RNP complex disassembly|ribonucleoprotein complex disassembly http://purl.obolibrary.org/obo/GO_0032988 GO:0032987 biolink:BiologicalProcess protein-lipid complex disassembly The disaggregation of a protein-lipid complex into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0032987 GO:0032986 biolink:BiologicalProcess protein-DNA complex disassembly The disaggregation of a protein-DNA complex into its constituent components. go.json DNA-protein complex disassembly http://purl.obolibrary.org/obo/GO_0032986 GO:0032985 biolink:BiologicalProcess protein-carbohydrate complex disassembly The disaggregation of a protein-carbohydrate complex into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0032985 GO:0032984 biolink:BiologicalProcess protein-containing complex disassembly The disaggregation of a protein-containing macromolecular complex into its constituent components. go.json cellular macromolecule complex disassembly|cellular protein complex disassembly|macromolecule complex disassembly|protein complex disassembly http://purl.obolibrary.org/obo/GO_0032984 GO:0032983 biolink:CellularComponent kainate selective glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits. go.json http://purl.obolibrary.org/obo/GO_0032983 GO:0032982 biolink:CellularComponent myosin filament A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. go.json myosin thick filament|thick filament http://purl.obolibrary.org/obo/GO_0032982 GO:0032981 biolink:BiologicalProcess mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. go.json mitochondrial NADH dehydrogenase complex (ubiquinone) assembly|mitochondrial complex I assembly http://purl.obolibrary.org/obo/GO_0032981 GO:0032980 biolink:BiologicalProcess keratinocyte activation A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines. go.json http://purl.obolibrary.org/obo/GO_0032980 GO:0032979 biolink:BiologicalProcess protein insertion into mitochondrial inner membrane from matrix The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix. go.json insertion of proteins into the mitochondrial membrane from the inner side|protein insertion into mitochondrial inner membrane from matrix side|protein insertion into mitochondrial membrane from inner side http://purl.obolibrary.org/obo/GO_0032979 GO:0032978 biolink:BiologicalProcess protein insertion into membrane from inner side The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side. go.json insertion of proteins into membrane from the inner side http://purl.obolibrary.org/obo/GO_0032978 GO:0032977 biolink:MolecularActivity membrane insertase activity Binds transmembrane domain-containing proteins and mediates their integration into a membrane. Reactome:R-HSA-1268025|Reactome:R-HSA-1299482|Reactome:R-HSA-1307803 go.json http://purl.obolibrary.org/obo/GO_0032977 GO:0032976 biolink:BiologicalProcess release of matrix enzymes from mitochondria The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process. go.json mAST release from mitochondria|release of aspartate aminotransferase from mitochondria http://purl.obolibrary.org/obo/GO_0032976 GO:0032975 biolink:BiologicalProcess amino acid transmembrane import into vacuole The directed movement of amino acids into the vacuole across the vacuolar membrane. go.json vacuolar amino acid import http://purl.obolibrary.org/obo/GO_0032975 GO:0032974 biolink:BiologicalProcess amino acid transmembrane export from vacuole The directed movement of amino acids out of the vacuole, across the vacuolar membrane. go.json amino acid efflux from vacuole|vacuolar amino acid export http://purl.obolibrary.org/obo/GO_0032974 GO:0032973 biolink:BiologicalProcess amino acid export across plasma membrane The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region. go.json amino acid efflux|amino acid export|amino acid transmembrane export http://purl.obolibrary.org/obo/GO_0032973 GO:0032972 biolink:BiologicalProcess regulation of muscle filament sliding speed Any process that modulates the velocity of muscle filament sliding. go.json http://purl.obolibrary.org/obo/GO_0032972 GO:0032971 biolink:BiologicalProcess regulation of muscle filament sliding Any process that modulates the frequency, rate or extent of muscle filament sliding. go.json http://purl.obolibrary.org/obo/GO_0032971 GO:0032970 biolink:BiologicalProcess regulation of actin filament-based process Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. go.json http://purl.obolibrary.org/obo/GO_0032970 GO:0032969 biolink:CellularComponent endosomal scaffold complex A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling. go.json MP1-p14 scaffolding complex|endosomal adaptor complex http://purl.obolibrary.org/obo/GO_0032969 GO:0032968 biolink:BiologicalProcess positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. go.json positive regulation of RNA elongation from RNA polymerase II promoter|positive regulation of gene-specific transcription elongation from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0032968 GO:0032967 biolink:BiologicalProcess positive regulation of collagen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. go.json positive regulation of collagen anabolism|positive regulation of collagen biosynthesis|positive regulation of collagen formation|positive regulation of collagen synthesis http://purl.obolibrary.org/obo/GO_0032967 GO:0032966 biolink:BiologicalProcess negative regulation of collagen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. go.json negative regulation of collagen anabolism|negative regulation of collagen biosynthesis|negative regulation of collagen formation|negative regulation of collagen synthesis http://purl.obolibrary.org/obo/GO_0032966 GO:0032965 biolink:BiologicalProcess regulation of collagen biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. go.json regulation of collagen anabolism|regulation of collagen biosynthesis|regulation of collagen formation|regulation of collagen synthesis http://purl.obolibrary.org/obo/GO_0032965 GO:0032964 biolink:BiologicalProcess collagen biosynthetic process The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). go.json collagen anabolism|collagen biosynthesis|collagen formation|collagen synthesis http://purl.obolibrary.org/obo/GO_0032964 GO:0032963 biolink:BiologicalProcess collagen metabolic process The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). go.json collagen metabolism http://purl.obolibrary.org/obo/GO_0032963 GO:0032962 biolink:BiologicalProcess positive regulation of inositol trisphosphate biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. go.json positive regulation of IP3 biosynthesis|positive regulation of IP3 biosynthetic process|positive regulation of inositol trisphosphate anabolism|positive regulation of inositol trisphosphate biosynthesis|positive regulation of inositol trisphosphate formation|positive regulation of inositol trisphosphate synthesis|positive regulation of myo-inositol trisphosphate biosynthesis|positive regulation of myo-inositol trisphosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0032962 GO:0032961 biolink:BiologicalProcess negative regulation of inositol trisphosphate biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. go.json negative regulation of IP3 biosynthesis|negative regulation of IP3 biosynthetic process|negative regulation of inositol trisphosphate anabolism|negative regulation of inositol trisphosphate biosynthesis|negative regulation of inositol trisphosphate formation|negative regulation of inositol trisphosphate synthesis|negative regulation of myo-inositol trisphosphate biosynthesis|negative regulation of myo-inositol trisphosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0032961 GO:0032960 biolink:BiologicalProcess regulation of inositol trisphosphate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. go.json regulation of IP3 biosynthesis|regulation of IP3 biosynthetic process|regulation of inositol trisphosphate anabolism|regulation of inositol trisphosphate biosynthesis|regulation of inositol trisphosphate formation|regulation of inositol trisphosphate synthesis|regulation of myo-inositol trisphosphate biosynthesis|regulation of myo-inositol trisphosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0032960 GO:0140629 biolink:MolecularActivity small conductance calcium-activated potassium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel. go.json http://purl.obolibrary.org/obo/GO_0140629 GO:0140628 biolink:MolecularActivity outward rectifier potassium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel. go.json http://purl.obolibrary.org/obo/GO_0140628 GO:0101020 biolink:MolecularActivity estrogen 16-alpha-hydroxylase activity Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. go.json oestrogen 16-alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0101020 GO:0101021 biolink:MolecularActivity estrogen 2-hydroxylase activity Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O. go.json oestrogen 2-hydroxylase activity http://purl.obolibrary.org/obo/GO_0101021 GO:0140621 biolink:CellularComponent type I pilus A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits. go.json type 1 pilus|type I fimbriae|type I pili http://purl.obolibrary.org/obo/GO_0140621 GO:0101024 biolink:BiologicalProcess mitotic nuclear membrane organization A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. go.json nuclear membrane organization involved in mitotic nuclear division http://purl.obolibrary.org/obo/GO_0101024 GO:0140620 biolink:MolecularActivity DNA strand exchange inhibitor activity Binds to and stops, prevents or reduces a DNA strand exchange activity. go.json http://purl.obolibrary.org/obo/GO_0140620 GO:0101023 biolink:BiologicalProcess vascular endothelial cell proliferation The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0101023 GO:0140623 biolink:BiologicalProcess type I pilus assembly The assembly from its constituent parts of a type I pilus. go.json T1P assembly|type 1 pilus biogenesis|type I fimbria assembly|type I fimbria biogenesis|type I fimbriae assembly|type I fimbriae biogenesis|type I fimbrial assembly|type I fimbrial biogenesis|type I fimbrium assembly|type I fimbrium biogenesis http://purl.obolibrary.org/obo/GO_0140623 GO:0101026 biolink:BiologicalProcess mitotic nuclear membrane biogenesis A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division. go.json nuclear membrane biogenesis involved in mitotic nuclear division http://purl.obolibrary.org/obo/GO_0101026 GO:0101025 biolink:BiologicalProcess nuclear membrane biogenesis The process in which a nuclear membrane is synthesized, aggregates, and bonds together. go.json http://purl.obolibrary.org/obo/GO_0101025 GO:0140622 biolink:CellularComponent ER-to-endosome phospholipid transfer complex Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site. go.json http://purl.obolibrary.org/obo/GO_0140622 GO:0140625 biolink:MolecularActivity opioid growth factor receptor activity Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes. go.json met-enkephalin receptor activity|metenkefalin receptor activity|methionine enkephalin receptor activity http://purl.obolibrary.org/obo/GO_0140625 GO:0101028 biolink:BiologicalProcess obsolete positive regulation of liquid surface tension OBSOLETE. Any process that activates or increases the surface tension of a liquid. go.json positive regulation of surface tension of a liquid True http://purl.obolibrary.org/obo/GO_0101028 GO:0101027 biolink:BiologicalProcess optical nerve axon regeneration The regrowth of axons of the optical nerve following their loss or damage. go.json http://purl.obolibrary.org/obo/GO_0101027 GO:0140624 biolink:BiologicalProcess EGAD pathway The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation. go.json http://purl.obolibrary.org/obo/GO_0140624 GO:0140627 biolink:BiologicalProcess ubiquitin-dependent protein catabolic process via the C-end degron rule pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. go.json DesCEND http://purl.obolibrary.org/obo/GO_0140627 GO:0101029 biolink:BiologicalProcess obsolete negative regulation of liquid surface tension OBSOLETE. Any process that prevents or reduces the surface tension of a liquid. go.json negative regulation of surface tension of a liquid True http://purl.obolibrary.org/obo/GO_0101029 GO:0140626 biolink:BiologicalProcess opioid growth factor receptor signaling pathway The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p16 (CDKN2A). Wikipedia:OGFr|Wikipedia:Opioid_receptor go.json http://purl.obolibrary.org/obo/GO_0140626 GO:0140618 biolink:MolecularActivity ferric-chelate reductase (NADH) activity Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH. EC:1.16.1.7|MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN|RHEA:15061 go.json NADH:Fe(3+) oxidoreductase activity|NADH:Fe3+ oxidoreductase activity|ferric chelate reductase activity|iron chelate reductase activity http://purl.obolibrary.org/obo/GO_0140618 GO:0140617 biolink:BiologicalProcess obsolete transvection OBSOLETE. An epigenetic regulation of transcription by physical interaction between a cis-acting element (enhancer, silencer) of one allele on one chromosome and the promoter of the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression. go.json True http://purl.obolibrary.org/obo/GO_0140617 GO:0140619 biolink:MolecularActivity DNA strand exchange activator activity Binds to and increases a DNA strand exchange activity. go.json http://purl.obolibrary.org/obo/GO_0140619 GO:0101031 biolink:CellularComponent protein folding chaperone complex A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. go.json chaperone complex http://purl.obolibrary.org/obo/GO_0101031 GO:0101030 biolink:BiologicalProcess tRNA-guanine transglycosylation The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. go.json http://purl.obolibrary.org/obo/GO_0101030 GO:0140610 biolink:MolecularActivity RNA sequestering activity Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. go.json http://purl.obolibrary.org/obo/GO_0140610 GO:0140612 biolink:MolecularActivity DNA damage sensor activity A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response. go.json DNA damage sensing activity http://purl.obolibrary.org/obo/GO_0140612 GO:0140614 biolink:BiologicalProcess 1,8-dihydroxynaphthalene-melanin biosynthetic process The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin. go.json DHN-melanin biosynthesis http://purl.obolibrary.org/obo/GO_0140614 GO:0140613 biolink:MolecularActivity P-type manganese transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate. RHEA:66820 go.json http://purl.obolibrary.org/obo/GO_0140613 GO:0140616 biolink:MolecularActivity iodotyrosine deiodinase activity Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates. EC:1.21.1.1|RHEA:32479 go.json iodide peroxidase-tyrosine iodinase activity|iodotyrosine deiodase activity|monoiodotyrosine deiodinase activity|tyrosine iodinase activity http://purl.obolibrary.org/obo/GO_0140616 GO:0140615 biolink:CellularComponent ATP-dependent citrate lyase complex A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA. go.json citrate lyase complex|citrate synthase complex http://purl.obolibrary.org/obo/GO_0140615 GO:0140643 biolink:MolecularActivity hydroxymethylglutaryl-CoA reductase (NADH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH. EC:1.1.1.88|KEGG_REACTION:R02081|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN|RHEA:14833 go.json 3-hydroxy-3-methylglutaryl coenzyme A reductase activity|HMG-CoA reductase activity|beta-hydroxy-beta-methylglutaryl CoA-reductase activity|beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity|hydroxymethylglutaryl coenzyme A reductase activity http://purl.obolibrary.org/obo/GO_0140643 GO:0140642 biolink:BiologicalProcess meiotic spindle formation (spindle phase two) The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase. go.json http://purl.obolibrary.org/obo/GO_0140642 GO:0042301 biolink:MolecularActivity phosphate ion binding Binding to a phosphate ion. go.json http://purl.obolibrary.org/obo/GO_0042301 GO:0140645 biolink:BiologicalProcess neutrophic extracellular trap formation The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens. http://purl.obolibrary.org/obo/TXPO_0002149 go.json NET formation http://purl.obolibrary.org/obo/GO_0140645 GO:0140644 biolink:CellularComponent neutrophil extracellular trap Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms. go.json NET http://purl.obolibrary.org/obo/GO_0140644 GO:0042300 biolink:MolecularActivity beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin. EC:5.4.99.-|MetaCyc:RXN-7570 go.json oxidosqualene:beta-amyrin cyclase activity http://purl.obolibrary.org/obo/GO_0042300 GO:0140647 biolink:BiologicalProcess P450-containing electron transport chain A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways. Wikipedia:P450-containing_systems go.json P450-containing system http://purl.obolibrary.org/obo/GO_0140647 GO:0140646 biolink:BiologicalProcess negative regulation of pre-B cell receptor expression Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells. go.json http://purl.obolibrary.org/obo/GO_0140646 GO:0140649 biolink:BiologicalProcess cell-to-cell migration by invasive hypha The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction. go.json host tissue colonization|invasive growth|invasive hyphae formation|plant tissue colonization http://purl.obolibrary.org/obo/GO_0140649 GO:0140648 biolink:BiologicalProcess positive regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. go.json http://purl.obolibrary.org/obo/GO_0140648 GO:0042307 biolink:BiologicalProcess positive regulation of protein import into nucleus Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. go.json activation of protein import into nucleus|positive regulation of protein import into cell nucleus|positive regulation of protein transport from cytoplasm to nucleus|positive regulation of protein-nucleus import|stimulation of protein import into nucleus|up regulation of protein import into nucleus|up-regulation of protein import into nucleus|upregulation of protein import into nucleus http://purl.obolibrary.org/obo/GO_0042307 GO:0042306 biolink:BiologicalProcess regulation of protein import into nucleus Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. go.json regulation of protein import into cell nucleus|regulation of protein transport from cytoplasm to nucleus|regulation of protein-nucleus import http://purl.obolibrary.org/obo/GO_0042306 GO:0042309 biolink:BiologicalProcess homoiothermy Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. go.json antifreeze activity|ice nucleation activity|ice nucleation inhibitor activity http://purl.obolibrary.org/obo/GO_0042309 GO:0042308 biolink:BiologicalProcess negative regulation of protein import into nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. go.json down regulation of protein import into nucleus|down-regulation of protein import into nucleus|downregulation of protein import into nucleus|inhibition of protein import into nucleus|negative regulation of protein import into cell nucleus|negative regulation of protein transport from cytoplasm to nucleus|negative regulation of protein-nucleus import http://purl.obolibrary.org/obo/GO_0042308 GO:0042303 biolink:BiologicalProcess molting cycle The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. go.json http://purl.obolibrary.org/obo/GO_0042303 goslim_drosophila|goslim_pir GO:0042302 biolink:MolecularActivity structural constituent of cuticle The action of a molecule that contributes to the structural integrity of a cuticle. go.json http://purl.obolibrary.org/obo/GO_0042302 goslim_drosophila GO:0140641 biolink:BiologicalProcess mitotic spindle formation (spindle phase two) The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase. go.json metaphase spindle stability|metaphase spindle stabilization http://purl.obolibrary.org/obo/GO_0140641 GO:0042305 biolink:BiologicalProcess specification of segmental identity, mandibular segment The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0042305 GO:0042304 biolink:BiologicalProcess regulation of fatty acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. go.json regulation of fatty acid anabolism|regulation of fatty acid biosynthesis|regulation of fatty acid formation|regulation of fatty acid synthesis http://purl.obolibrary.org/obo/GO_0042304 GO:0140640 biolink:MolecularActivity catalytic activity, acting on a nucleic acid Catalytic activity that acts to modify a nucleic acid. go.json http://purl.obolibrary.org/obo/GO_0140640 GO:0140639 biolink:BiologicalProcess positive regulation of pyroptosis Any process that increases the frequency, rate or extent of pyroptosis. go.json http://purl.obolibrary.org/obo/GO_0140639 GO:0042310 biolink:BiologicalProcess vasoconstriction A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. Wikipedia:Vasoconstriction go.json negative regulation of blood vessel size http://purl.obolibrary.org/obo/GO_0042310 GO:0140632 biolink:BiologicalProcess canonical inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex. go.json http://purl.obolibrary.org/obo/GO_0140632 GO:0140631 biolink:MolecularActivity aldehyde dehydrogenase (NAD+) inhibitor activity Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+). go.json http://purl.obolibrary.org/obo/GO_0140631 GO:0140634 biolink:CellularComponent CARD8 inflammasome complex An inflammasome complex that consists of CARD8 and CASP1. go.json http://purl.obolibrary.org/obo/GO_0140634 GO:0042312 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042312 GO:0042311 biolink:BiologicalProcess vasodilation An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. Wikipedia:Vasodilation go.json positive regulation of blood vessel size|vasodilatation http://purl.obolibrary.org/obo/GO_0042311 GO:0140633 biolink:BiologicalProcess CARD8 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex. go.json http://purl.obolibrary.org/obo/GO_0140633 GO:0140636 biolink:BiologicalProcess copper import into the mitochondrion The process in which copper is transported from the cytosol into the mitochondrial matrix. go.json http://purl.obolibrary.org/obo/GO_0140636 GO:0140635 biolink:BiologicalProcess neutrophil dispersal The movement of a neutrophil away from the site of wound or infection following its initial migration to the site. go.json http://purl.obolibrary.org/obo/GO_0140635 GO:0140638 biolink:CellularComponent small ribosomal subunit processing complex A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p. go.json small ribosomal subunit maturation complex http://purl.obolibrary.org/obo/GO_0140638 GO:0042318 biolink:BiologicalProcess penicillin biosynthetic process The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json penicillin anabolism|penicillin biosynthesis|penicillin formation|penicillin synthesis http://purl.obolibrary.org/obo/GO_0042318 GO:0042317 biolink:BiologicalProcess penicillin catabolic process The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. go.json penicillin breakdown|penicillin catabolism|penicillin degradation http://purl.obolibrary.org/obo/GO_0042317 GO:0042319 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042319 GO:0042314 biolink:MolecularActivity bacteriochlorophyll binding Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants. go.json http://purl.obolibrary.org/obo/GO_0042314 GO:0042313 biolink:BiologicalProcess protein kinase C deactivation Any process resulting in the inhibition or termination of the activity of protein kinase C. go.json PKC deactivation http://purl.obolibrary.org/obo/GO_0042313 GO:0140630 biolink:MolecularActivity all-trans-phytoene synthase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate. go.json phytoene synthase activity http://purl.obolibrary.org/obo/GO_0140630 GO:0042316 biolink:BiologicalProcess penicillin metabolic process The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus. go.json penicillin metabolism http://purl.obolibrary.org/obo/GO_0042316 GO:0042315 biolink:MolecularActivity obsolete cytosol nonspecific dipeptidase activity OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. go.json Gly-Leu hydrolase activity|L-amino-acyl-L-amino-acid hydrolase activity|L-prolylglycine dipeptidase activity|N(2)-beta-alanylarginine dipeptidase activity|N2-beta-alanylarginine dipeptidase activity|Pro-X dipeptidase activity|cytosol non-specific dipeptidase activity|cytosol nonspecific dipeptidase activity|diglycinase activity|glycyl-L-leucine dipeptidase activity|glycyl-L-leucine hydrolase activity|glycyl-L-leucine peptidase activity|glycyl-glycine dipeptidase activity|glycyl-leucine dipeptidase activity|glycylleucine dipeptide hydrolase activity|glycylleucine hydrolase activity|glycylleucine peptidase activity|human cytosolic non-specific dipeptidase activity|iminodipeptidase activity|non-specific dipeptidase activity|peptidase A activity|prolinase activity|prolyl dipeptidase activity|prolylglycine dipeptidase activity True http://purl.obolibrary.org/obo/GO_0042315 GO:0042321 biolink:BiologicalProcess negative regulation of circadian sleep/wake cycle, sleep Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. go.json down regulation of circadian sleep/wake cycle, sleep|down-regulation of circadian sleep/wake cycle, sleep|downregulation of circadian sleep/wake cycle, sleep|inhibition of circadian sleep/wake cycle, sleep|negative regulation of sleep http://purl.obolibrary.org/obo/GO_0042321 GO:0042320 biolink:BiologicalProcess regulation of circadian sleep/wake cycle, REM sleep Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep. go.json regulation of REM sleep http://purl.obolibrary.org/obo/GO_0042320 GO:0042323 biolink:BiologicalProcess negative regulation of circadian sleep/wake cycle, non-REM sleep Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. go.json down regulation of circadian sleep/wake cycle, non-REM sleep|down-regulation of circadian sleep/wake cycle, non-REM sleep|downregulation of circadian sleep/wake cycle, non-REM sleep|inhibition of circadian sleep/wake cycle, non-REM sleep|negative regulation of non-REM sleep http://purl.obolibrary.org/obo/GO_0042323 GO:0042322 biolink:BiologicalProcess negative regulation of circadian sleep/wake cycle, REM sleep Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep. go.json down regulation of circadian sleep/wake cycle, REM sleep|down-regulation of circadian sleep/wake cycle, REM sleep|downregulation of circadian sleep/wake cycle, REM sleep|inhibition of circadian sleep/wake cycle, REM sleep|negative regulation of REM sleep http://purl.obolibrary.org/obo/GO_0042322 GO:0042329 biolink:MolecularActivity structural constituent of collagen and cuticulin-based cuticle The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans. go.json structural constituent of cuticle http://purl.obolibrary.org/obo/GO_0042329 GO:0042328 biolink:MolecularActivity heparan sulfate N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. go.json heparan sulphate N-acetylglucosaminyltransferase activity|heparin N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0042328 GO:0042325 biolink:BiologicalProcess regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. go.json http://purl.obolibrary.org/obo/GO_0042325 GO:0042324 biolink:MolecularActivity orexin receptor binding Binding to an orexin receptor. go.json hypocretin receptor binding|hypocretin receptor ligand|orexin receptor ligand http://purl.obolibrary.org/obo/GO_0042324 GO:0042327 biolink:BiologicalProcess positive regulation of phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. go.json activation of phosphorylation|stimulation of phosphorylation|up regulation of phosphorylation|up-regulation of phosphorylation|upregulation of phosphorylation http://purl.obolibrary.org/obo/GO_0042327 GO:0042326 biolink:BiologicalProcess negative regulation of phosphorylation Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. go.json down regulation of phosphorylation|down-regulation of phosphorylation|downregulation of phosphorylation|inhibition of phosphorylation http://purl.obolibrary.org/obo/GO_0042326 GO:0042332 biolink:BiologicalProcess gravitaxis The directed movement of a motile cell or organism in response to gravity. go.json geotactic behavior|geotactic behaviour|geotaxis|gravitactic behavior|gravitactic behaviour|taxis in response to gravitational stimulus|taxis in response to gravity http://purl.obolibrary.org/obo/GO_0042332 GO:0042331 biolink:BiologicalProcess phototaxis The directed movement of a motile cell or organism in response to light. Wikipedia:Phototaxis go.json phototactic behavior|phototactic behaviour|taxis in response to light http://purl.obolibrary.org/obo/GO_0042331 GO:0042334 biolink:BiologicalProcess taxis to electron acceptor The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate. go.json taxis in response to electron acceptor http://purl.obolibrary.org/obo/GO_0042334 GO:0042333 biolink:BiologicalProcess chemotaxis to oxidizable substrate The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose. go.json taxis in response to oxidizable substrate http://purl.obolibrary.org/obo/GO_0042333 GO:0042330 biolink:BiologicalProcess taxis The directed movement of a motile cell or organism in response to an external stimulus. Wikipedia:Taxis go.json directed movement in response to stimulus http://purl.obolibrary.org/obo/GO_0042330 GO:0042339 biolink:BiologicalProcess keratan sulfate metabolic process The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. go.json keratan sulfate metabolism|keratan sulphate metabolic process|keratan sulphate metabolism http://purl.obolibrary.org/obo/GO_0042339 GO:0042336 biolink:BiologicalProcess obsolete cuticle development involved in protein-based cuticle molting cycle OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species. go.json cuticle anabolism during molting|cuticle biosynthetic process during molting|cuticle development involved in protein-based cuticle molting cycle|cuticle formation during molting|cuticle synthesis during molting True http://purl.obolibrary.org/obo/GO_0042336 GO:0042335 biolink:BiologicalProcess cuticle development The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss. go.json cuticle anabolism|cuticle biosynthesis|cuticle biosynthetic process|cuticle formation|cuticle synthesis http://purl.obolibrary.org/obo/GO_0042335 goslim_drosophila GO:0042338 biolink:BiologicalProcess cuticle development involved in collagen and cuticulin-based cuticle molting cycle Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans. go.json collagen and cuticulin-based cuticle development during molting|cuticle anabolism during molting|cuticle biosynthetic process during molting|cuticle formation during molting|cuticle synthesis during molting http://purl.obolibrary.org/obo/GO_0042338 GO:0042337 biolink:BiologicalProcess cuticle development involved in chitin-based cuticle molting cycle The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster. go.json chitin-based cuticle development during molting|cuticle anabolism during molting|cuticle biosynthetic process during molting|cuticle formation during molting|cuticle synthesis during molting http://purl.obolibrary.org/obo/GO_0042337 GO:0140609 biolink:BiologicalProcess phycocyanobilin biosynthetic process The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA). go.json phycocyanobilin biosynthesis http://purl.obolibrary.org/obo/GO_0140609 GO:0140608 biolink:MolecularActivity cysteine-type endopeptidase activator activity Binds to and increases the activity of a cysteine-type endopeptidase. go.json caspase activator activator activity http://purl.obolibrary.org/obo/GO_0140608 GO:0101002 biolink:CellularComponent ficolin-1-rich granule Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry. go.json ficolin granule|ficolin-1 rich granule http://purl.obolibrary.org/obo/GO_0101002 GO:0042343 biolink:BiologicalProcess indole glucosinolate metabolic process The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan. go.json indole glucosinolate metabolism http://purl.obolibrary.org/obo/GO_0042343 GO:0042342 biolink:BiologicalProcess cyanogenic glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. go.json cyanogenic glycoside breakdown|cyanogenic glycoside catabolism|cyanogenic glycoside degradation http://purl.obolibrary.org/obo/GO_0042342 GO:0101004 biolink:CellularComponent cytolytic granule membrane The lipid bilayer surrounding the cytolytic granule. go.json http://purl.obolibrary.org/obo/GO_0101004 GO:0042345 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042345 GO:0042344 biolink:BiologicalProcess indole glucosinolate catabolic process The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. go.json indole glucosinolate breakdown|indole glucosinolate catabolism|indole glucosinolate degradation http://purl.obolibrary.org/obo/GO_0042344 GO:0101003 biolink:CellularComponent ficolin-1-rich granule membrane The lipid bilayer surrounding a ficolin-1-rich granule. go.json http://purl.obolibrary.org/obo/GO_0101003 GO:0101006 biolink:MolecularActivity protein histidine phosphatase activity Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. EC:3.9.1.3|RHEA:47964 go.json phosphohistidine phosphatase activity http://purl.obolibrary.org/obo/GO_0101006 GO:0140603 biolink:MolecularActivity obsolete ATP hydrolysis activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. go.json True http://purl.obolibrary.org/obo/GO_0140603 GO:0140602 biolink:CellularComponent nucleolar peripheral inclusion body Inclusion bodies located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress or starvation. go.json NuRs|nucleolar ring http://purl.obolibrary.org/obo/GO_0140602 GO:0101005 biolink:MolecularActivity deubiquitinase activity An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. Reactome:R-HSA-9674127 go.json ubiquitinyl hydrolase activity http://purl.obolibrary.org/obo/GO_0101005 GO:0101008 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter in response to increased salt OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json True http://purl.obolibrary.org/obo/GO_0101008 GO:0140605 biolink:MolecularActivity proton motive force-driven motor activity A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella. go.json http://purl.obolibrary.org/obo/GO_0140605 GO:0042341 biolink:BiologicalProcess cyanogenic glycoside metabolic process The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. go.json cyanogenic glycoside metabolism http://purl.obolibrary.org/obo/GO_0042341 GO:0101007 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter in response to salt stress OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json True http://purl.obolibrary.org/obo/GO_0101007 GO:0140604 biolink:BiologicalProcess mycofactocin biosynthetic process The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA. go.json http://purl.obolibrary.org/obo/GO_0140604 GO:0042340 biolink:BiologicalProcess keratan sulfate catabolic process The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. go.json keratan sulfate breakdown|keratan sulfate catabolism|keratan sulfate degradation|keratan sulphate catabolic process|keratan sulphate catabolism http://purl.obolibrary.org/obo/GO_0042340 GO:0042347 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042347 GO:0042346 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042346 GO:0042349 biolink:MolecularActivity guiding stereospecific synthesis activity The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis. go.json dirigent protein http://purl.obolibrary.org/obo/GO_0042349 GO:0042348 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042348 GO:0101011 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0101011 GO:0101010 biolink:BiologicalProcess pulmonary blood vessel remodeling The reorganization or renovation of existing pulmonary blood vessels. go.json pulmonary blood vessel remodelling http://purl.obolibrary.org/obo/GO_0101010 GO:0042354 biolink:BiologicalProcess L-fucose metabolic process The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. go.json L-fucose metabolism http://purl.obolibrary.org/obo/GO_0042354 GO:0101013 biolink:MolecularActivity mechanosensitive voltage-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json mechanically-modulated voltage-gated sodium channel activity http://purl.obolibrary.org/obo/GO_0101013 GO:0042353 biolink:BiologicalProcess fucose biosynthetic process The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose). go.json fucose anabolism|fucose biosynthesis|fucose formation|fucose synthesis http://purl.obolibrary.org/obo/GO_0042353 GO:0101012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0101012 GO:0042356 biolink:MolecularActivity GDP-4-dehydro-D-rhamnose reductase activity Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed. EC:1.1.1.187|MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN go.json GDP-4-keto-6-deoxy-D-mannose reductase activity|GDP-4-keto-D-rhamnose reductase activity|GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity|guanosine diphosphate-4-keto-D-rhamnose reductase activity http://purl.obolibrary.org/obo/GO_0042356 GO:0101014 biolink:MolecularActivity [isocitrate dehydrogenase (NADP+)] phosphatase activity Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate. MetaCyc:ICITDEHASE-KIN-PHOSPHA go.json isocitrate dehydrogenase kinase/phosphatase activity http://purl.obolibrary.org/obo/GO_0101014 GO:0042355 biolink:BiologicalProcess L-fucose catabolic process The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). go.json L-fucose breakdown|L-fucose catabolism|L-fucose degradation http://purl.obolibrary.org/obo/GO_0042355 GO:0042350 biolink:BiologicalProcess GDP-L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. go.json GDP-L-fucose anabolism|GDP-L-fucose biosynthesis|GDP-L-fucose formation|GDP-L-fucose synthesis http://purl.obolibrary.org/obo/GO_0042350 GO:0101017 biolink:BiologicalProcess regulation of mitotic DNA replication initiation from late origin Any process that modulates the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication. go.json regulation of late replication origin firing http://purl.obolibrary.org/obo/GO_0101017 GO:0101016 biolink:MolecularActivity FMN-binding domain binding Binding to the FMN-binding domain of a protein. go.json http://purl.obolibrary.org/obo/GO_0101016 GO:0042352 biolink:BiologicalProcess GDP-L-fucose salvage The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30). MetaCyc:PWY-6 go.json GDP-L-fucose biosynthesis, salvage pathway|GDP-L-fucose biosynthetic process, salvage pathway http://purl.obolibrary.org/obo/GO_0042352 GO:0101019 biolink:CellularComponent nucleolar exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. go.json http://purl.obolibrary.org/obo/GO_0101019 GO:0042351 biolink:BiologicalProcess 'de novo' GDP-L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). MetaCyc:PWY-66 go.json 'de novo' GDP-L-fucose anabolism|'de novo' GDP-L-fucose biosynthesis|'de novo' GDP-L-fucose formation|'de novo' GDP-L-fucose synthesis|GDP-L-fucose biosynthesis, de novo pathway|GDP-L-fucose biosynthetic process, de novo pathway http://purl.obolibrary.org/obo/GO_0042351 GO:0101018 biolink:BiologicalProcess negative regulation of mitotic DNA replication initiation from late origin Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication. go.json negative regulation of late replication origin firing http://purl.obolibrary.org/obo/GO_0101018 GO:0042358 biolink:BiologicalProcess thiamine diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. go.json TPP catabolic process|TPP catabolism|thiamin diphosphate breakdown|thiamin diphosphate catabolic process|thiamin diphosphate catabolism|thiamin diphosphate degradation|thiamin pyrophosphate catabolic process|thiamin pyrophosphate catabolism|thiamine diphosphate catabolism|thiamine pyrophosphate catabolic process|thiamine pyrophosphate catabolism http://purl.obolibrary.org/obo/GO_0042358 GO:0042357 biolink:BiologicalProcess thiamine diphosphate metabolic process The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. go.json TPP metabolic process|TPP metabolism|thiamin diphosphate metabolic process|thiamin diphosphate metabolism|thiamin pyrophosphate metabolic process|thiamin pyrophosphate metabolism|thiamine diphosphate metabolism|thiamine pyrophosphate metabolic process|thiamine pyrophosphate metabolism http://purl.obolibrary.org/obo/GO_0042357 GO:0042359 biolink:BiologicalProcess vitamin D metabolic process The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). go.json calciferol metabolic process|calciferol metabolism|cholecalciferol metabolic process|cholecalciferol metabolism|ergocalciferol metabolic process|ergocalciferol metabolism|vitamin D metabolism http://purl.obolibrary.org/obo/GO_0042359 GO:0150035 biolink:BiologicalProcess regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0150035 goslim_synapse GO:0150034 biolink:CellularComponent distal axon That part of an axon close to and including the growth cone or the axon terminus. go.json distal part of axon|distal part of the axon http://purl.obolibrary.org/obo/GO_0150034 GO:0150033 biolink:BiologicalProcess negative regulation of protein localization to lysosome Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome. go.json http://purl.obolibrary.org/obo/GO_0150033 GO:0150032 biolink:BiologicalProcess positive regulation of protein localization to lysosome Any process that activates or increases the frequency, rate or extent of protein localization to lysosome. go.json http://purl.obolibrary.org/obo/GO_0150032 GO:0150031 biolink:BiologicalProcess regulation of protein localization to lysosome Any process that modulates the frequency, rate or extent of protein localization to lysosome. go.json http://purl.obolibrary.org/obo/GO_0150031 GO:0150038 biolink:BiologicalProcess postsynaptic dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels. go.json http://purl.obolibrary.org/obo/GO_0150038 goslim_synapse GO:0150037 biolink:BiologicalProcess regulation of calcium-dependent activation of synaptic vesicle fusion Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion. go.json http://purl.obolibrary.org/obo/GO_0150037 goslim_synapse GO:0150036 biolink:BiologicalProcess regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0150036 goslim_synapse GO:0140698 biolink:BiologicalProcess attachment of telomeric heterochromatin to nuclear envelope The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation. go.json attachment of telomeres to nuclear envelope|attachment of telomeric chromatin to nuclear envelope|heterochromatin organization http://purl.obolibrary.org/obo/GO_0140698 GO:0150045 biolink:BiologicalProcess regulation of synaptic signaling by nitric oxide Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide. go.json http://purl.obolibrary.org/obo/GO_0150045 goslim_synapse GO:0150044 biolink:BiologicalProcess regulation of postsynaptic dense core vesicle exocytosis Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis. go.json http://purl.obolibrary.org/obo/GO_0150044 goslim_synapse GO:0150043 biolink:MolecularActivity structural constituent of synapse-associated extracellular matrix The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. go.json extra-synaptic extracellular matrix structural constituent|structural constituent of extra-synaptic extracellular matrix|synapse-associated extracellular matrix structural constituent http://purl.obolibrary.org/obo/GO_0150043 goslim_synapse GO:0140699 biolink:MolecularActivity cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP. go.json cyclic-GMP-AMP synthase activity http://purl.obolibrary.org/obo/GO_0140699 gocheck_do_not_annotate GO:0140690 biolink:CellularComponent dihydropyrimidine dehydrogenase (NAD+) complex A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT. MetaCyc:CPLX0-7788 go.json http://purl.obolibrary.org/obo/GO_0140690 GO:0140692 biolink:MolecularActivity very long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long chain fatty acid is a fatty acid with an aliphatic tail of 22 or more carbons. RHEA:67952 go.json http://purl.obolibrary.org/obo/GO_0140692 GO:0140691 biolink:MolecularActivity RNA folding chaperone Binding to an RNA or an RNA-containing complex to assist the folding process. go.json http://purl.obolibrary.org/obo/GO_0140691 GO:0140694 biolink:BiologicalProcess non-membrane-bounded organelle assembly The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. go.json non-membrane-bounded organelle formation|non-membrane-enclosed organelle assembly|non-membrane-enclosed organelle formation http://purl.obolibrary.org/obo/GO_0140694 GO:0140693 biolink:MolecularActivity molecular condensate scaffold activity Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. go.json phase separation nucleation activity|phase separation nucleator activity http://purl.obolibrary.org/obo/GO_0140693 GO:0150048 biolink:CellularComponent cerebellar granule cell to Purkinje cell synapse A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum. go.json cerebellar parallel fiber to Purkinje cell synapse http://purl.obolibrary.org/obo/GO_0150048 goslim_synapse GO:0140696 biolink:MolecularActivity (S)-2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol. EC:1.1.5.13|RHEA:58664 go.json L-2-hydroxyglutarate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0140696 GO:0150047 biolink:MolecularActivity G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. go.json G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential http://purl.obolibrary.org/obo/GO_0150047 goslim_synapse GO:0150013 biolink:BiologicalProcess negative regulation of neuron projection arborization Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. go.json negative regulation of neurite arborization|negative regulation of neurite branching|negative regulation of neuron projection branching http://purl.obolibrary.org/obo/GO_0150013 GO:0150012 biolink:BiologicalProcess positive regulation of neuron projection arborization Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. go.json positive regulation of neurite arborization|positive regulation of neurite branching|positive regulation of neuron projection branching http://purl.obolibrary.org/obo/GO_0150012 GO:0150011 biolink:BiologicalProcess regulation of neuron projection arborization Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. go.json regulation of neurite arborization|regulation of neurite branching|regulation of neuron projection branching http://purl.obolibrary.org/obo/GO_0150011 GO:0150019 biolink:BiologicalProcess basal dendrite morphogenesis The process in which the anatomical structures of a basal dendrite are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0150019 GO:0150018 biolink:BiologicalProcess basal dendrite development The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0150018 GO:0150017 biolink:CellularComponent basal proximal dendrite Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma). go.json http://purl.obolibrary.org/obo/GO_0150017 GO:0150016 biolink:CellularComponent basal distal dendrite Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma). go.json http://purl.obolibrary.org/obo/GO_0150016 GO:0150015 biolink:CellularComponent apical proximal dendrite The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma). go.json http://purl.obolibrary.org/obo/GO_0150015 GO:0150014 biolink:CellularComponent apical distal dendrite Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma). go.json http://purl.obolibrary.org/obo/GO_0150014 GO:0150024 biolink:BiologicalProcess oxidised low-density lipoprotein particle clearance The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json ox-LDL particle clearance|oxLDL particle clearance|oxidised LDL particle clearance|oxidized LDL particle clearance|oxidized low-density lipoprotein particle clearance http://purl.obolibrary.org/obo/GO_0150024 GO:0150023 biolink:BiologicalProcess apical dendrite arborization The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches. go.json http://purl.obolibrary.org/obo/GO_0150023 GO:0150022 biolink:BiologicalProcess apical dendrite development The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0150022 GO:0150021 biolink:BiologicalProcess apical dendrite morphogenesis The process in which the anatomical structures of an apical dendrite are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0150021 GO:0150020 biolink:BiologicalProcess basal dendrite arborization The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches. go.json http://purl.obolibrary.org/obo/GO_0150020 GO:0150025 biolink:MolecularActivity oxidised low-density lipoprotein particle receptor activity Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis. go.json ox-LDL particle receptor activity|ox-LDL receptor activity|oxLDL particle receptor activity|oxLDL receptor activity|oxidised LDL particle receptor activity|oxidised LDL receptor activity|oxidised low-density lipoprotein receptor activity|oxidized LDL particle receptor activity|oxidized LDL receptor activity|oxidized low-density lipoprotein particle receptor activity|oxidized low-density lipoprotein receptor activity http://purl.obolibrary.org/obo/GO_0150025 GO:0140665 biolink:MolecularActivity ATP-dependent H3-H4 histone complex chaperone activity A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis. go.json ATP-dependent H3-H4 histone complex loader activity|H3-H4 dimer loading activity|H3-H4 histone chaperone|H3-H4 histone complex loader activity|histone H3-H4 dimer loading activity|histone chaperone http://purl.obolibrary.org/obo/GO_0140665 GO:0140664 biolink:MolecularActivity ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. go.json ATP-dependent DNA damage sensing activity http://purl.obolibrary.org/obo/GO_0140664 GO:0140667 biolink:BiologicalProcess regulation of oxytocin production Any process that modulates the frequency, rate, or extent of production of oxytocin. go.json http://purl.obolibrary.org/obo/GO_0140667 GO:0140666 biolink:MolecularActivity annealing activity An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule. Reactome:R-HSA-5686642 go.json renaturation http://purl.obolibrary.org/obo/GO_0140666 GO:0140669 biolink:BiologicalProcess negative regulation of oxytocin production Any process that stops, prevents, or reduces the rate of production of oxytocin. go.json http://purl.obolibrary.org/obo/GO_0140669 GO:0140668 biolink:BiologicalProcess positive regulation of oxytocin production Any process that activates or increases the frequency, rate or extent of production of oxytocin. go.json http://purl.obolibrary.org/obo/GO_0140668 GO:0140661 biolink:MolecularActivity cytoskeletal motor inhibitor activity Binds to and stops, prevents, or reduces the activity of a motor protein. go.json motor activity inhibitor activity http://purl.obolibrary.org/obo/GO_0140661 GO:0140660 biolink:MolecularActivity cytoskeletal motor activator activity Binds to and increases the activity of a motor protein. go.json motor activity activator activity http://purl.obolibrary.org/obo/GO_0140660 GO:0140663 biolink:MolecularActivity ATP-dependent FeS chaperone activity Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0140663 GO:0140662 biolink:MolecularActivity ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0140662 GO:0140654 biolink:BiologicalProcess tryprostatin A biosynthetic process The chemical reactions and pathways resulting in the formation of tryprostatin A. go.json tryprostatin A anabolism|tryprostatin A biosynthesis|tryprostatin A formation|tryprostatin A synthesis http://purl.obolibrary.org/obo/GO_0140654 GO:0150002 biolink:CellularComponent distal dendrite The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma). go.json http://purl.obolibrary.org/obo/GO_0150002 GO:0140653 biolink:BiologicalProcess obsolete fumitremorgin C biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of the indole alkaloid fumitremorgin C. go.json fumitremorgin C anabolism|fumitremorgin C biosynthesis|fumitremorgin C formation|fumitremorgin C synthesis True http://purl.obolibrary.org/obo/GO_0140653 GO:0150001 biolink:CellularComponent primary dendrite A dendrite emerging from the cell body (the soma) of a neuron. go.json http://purl.obolibrary.org/obo/GO_0150001 GO:0140656 biolink:MolecularActivity endodeoxyribonuclease activator activity Binds to and increases the activity of an endodeoxyribonuclease. go.json http://purl.obolibrary.org/obo/GO_0140656 GO:0140655 biolink:BiologicalProcess mitochondrial proliferation The multiplication of mitochondria, resulting in the expansion of the number of mitochondria within a cell. go.json http://purl.obolibrary.org/obo/GO_0140655 GO:0140658 biolink:MolecularActivity ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. go.json ATP hydrolysis-dependent chromatin remodeler activity|ATP-dependent chromatin remodeller activity|ATP-dependent chromatin remodelling|ATPase-dependent chromatin remodeler activity|nucleosome-activated ATPase activity|nucleosome-dependent ATPase activity http://purl.obolibrary.org/obo/GO_0140658 GO:0140657 biolink:MolecularActivity ATP-dependent activity A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. go.json ATP hydrolysis-dependent activity|ATPase activity|ATPase activity, coupled|ATPase-dependent activity http://purl.obolibrary.org/obo/GO_0140657 gocheck_do_not_annotate|goslim_chembl|goslim_drosophila|goslim_generic|goslim_yeast|prokaryote_subset GO:0140659 biolink:MolecularActivity cytoskeletal motor regulator activity Binds to and modulates the activity of a motor protein. go.json motor activity regulator activity http://purl.obolibrary.org/obo/GO_0140659 GO:0150008 biolink:BiologicalProcess bulk synaptic vesicle endocytosis Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse. go.json ADBE|activity-dependent bulk endocytosis|activity-dependent bulk synaptic vesicle endocytosis|bulk endocytosis http://purl.obolibrary.org/obo/GO_0150008 GO:0150007 biolink:BiologicalProcess clathrin-dependent synaptic vesicle endocytosis Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds. go.json http://purl.obolibrary.org/obo/GO_0150007 GO:0140650 biolink:BiologicalProcess radial glia-guided pyramidal neuron migration The radial migration of a pyramidal neuron along radial glial cells. go.json radial glia-dependent neuronal migration http://purl.obolibrary.org/obo/GO_0140650 GO:0150006 biolink:CellularComponent urease activator complex A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function. go.json http://purl.obolibrary.org/obo/GO_0150006 GO:0150005 biolink:CellularComponent enzyme activator complex A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active. go.json http://purl.obolibrary.org/obo/GO_0150005 GO:0150004 biolink:CellularComponent dendritic spine origin The part of the dendritic spine neck where the spine arises from the dendritic shaft. go.json http://purl.obolibrary.org/obo/GO_0150004 GO:0140652 biolink:BiologicalProcess pyripyropene A biosynthetic process The chemical reactions and pathways resulting in the formation of pyripyropene A. go.json pyripyropene A anabolism|pyripyropene A biosynthesis|pyripyropene A formation|pyripyropene A synthesis http://purl.obolibrary.org/obo/GO_0140652 GO:0140651 biolink:BiologicalProcess futile creatine cycle The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis. go.json http://purl.obolibrary.org/obo/GO_0140651 GO:0150003 biolink:BiologicalProcess regulation of spontaneous synaptic transmission Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission. go.json http://purl.obolibrary.org/obo/GO_0150003 GO:0140681 biolink:MolecularActivity histone H3K36me2/H3K36me3 demethylase activity Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. EC:1.14.11.69|MetaCyc:RXN-20643|RHEA:60236 go.json histone H3-tri/dimethyl-lysine-36 demethylase activity|histone H3K36me2 demethylase activity|histone H3K36me3 demethylase activity http://purl.obolibrary.org/obo/GO_0140681 GO:0140680 biolink:MolecularActivity histone H3K36me/H3K36me2 demethylase activity Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. EC:1.14.11.27|MetaCyc:RXN-8661|RHEA:42032 go.json histone H3-di/monomethyl-lysine-36 demethylase activity|histone H3K36me demethylase activity|histone H3K36me2 demethylase activity http://purl.obolibrary.org/obo/GO_0140680 GO:0140683 biolink:MolecularActivity histone H3K9me/H3K9me2 demethylase activity Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. EC:1.14.11.65|RHEA:60188 go.json histone H3-di/monomethyl-lysine-9 demethylase activity|histone H3K9me demethylase activity|histone H3K9me2 demethylase activity http://purl.obolibrary.org/obo/GO_0140683 GO:0140682 biolink:MolecularActivity FAD-dependent H3K4me/H3K4me3 demethylase activity Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. EC:1.14.99.66|RHEA:60244 go.json histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity|histone H3K4me demethylase activity|histone H3K4me2 demethylase activity http://purl.obolibrary.org/obo/GO_0140682 GO:0140685 biolink:MolecularActivity FAD-dependent histone H3K9me/H3K9me2 demethylase activity Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. go.json histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity|histone H3K9me demethylase activity|histone H3K9me2 demethylase activity http://purl.obolibrary.org/obo/GO_0140685 GO:0140684 biolink:MolecularActivity histone H3K9me2/H3K9me3 demethylase activity Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. EC:1.14.11.66|RHEA:60200 go.json histone H3-tri/dimethyl-lysine-9 demethylase activity|histone H3K9me2 demethylase activity|histone H3K9me3 demethylase activity http://purl.obolibrary.org/obo/GO_0140684 GO:0140676 biolink:BiologicalProcess oscillatory cAMP signaling Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate. go.json cAMP relay http://purl.obolibrary.org/obo/GO_0140676 GO:0140675 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140675 GO:0140678 biolink:MolecularActivity molecular function inhibitor activity A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. go.json http://purl.obolibrary.org/obo/GO_0140678 GO:0140677 biolink:MolecularActivity molecular function activator activity A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. go.json http://purl.obolibrary.org/obo/GO_0140677 GO:0140679 biolink:MolecularActivity ABC-type sodium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out). EC:7.2.2.4|RHEA:14633|TC:3.A.1.115.1 go.json http://purl.obolibrary.org/obo/GO_0140679 GO:0140670 biolink:MolecularActivity cohesin unloader activity Facilitating a conformational change to unload a cohesin complex from sister chromatids. go.json cohesin unloading activity http://purl.obolibrary.org/obo/GO_0140670 GO:0140672 biolink:CellularComponent ATAC complex A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. go.json ADA2A-containing complex|Ada Two-A containing complex|Ada two A containing complex|Ada-Two-A-containing complex|G-ATAC complex|KAT2A-containing ATAC complex|KAT2B-containing ATAC complex http://purl.obolibrary.org/obo/GO_0140672 GO:0140671 biolink:CellularComponent ADA complex A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex. go.json ADA HAT complex|ADA histone acetyltransferase complex|Ada2/Gcn5/Ada3 transcription activator complex|scADA http://purl.obolibrary.org/obo/GO_0140671 GO:0140674 biolink:MolecularActivity ATP-dependent histone chaperone activity Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis. go.json ATP-dependent histone loader activity|ATP-dependent histone unloader activity|histone loader activity|histone loading activity|histone unloader activity|histone unloading activity|nucleosome remodeling activity http://purl.obolibrary.org/obo/GO_0140674 GO:0140673 biolink:BiologicalProcess transcription elongation-coupled chromatin remodeling A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. go.json DNA replication-independent chromatin organization|chromatin maintenance during transcription elongation|co-transcriptional chromatin reassembly|euchromatin maintenance during transcription elongation|maintainance of chromatin integrity during transcription elongation by RNAPII|maintenance of transcriptionally active chromatin during transcription elongation|transciptional elongation-coupled chromatin remodeling|transcription elongation coupled chromatin remodeling|transcriptional elongation-coupled chromatin remodeling http://purl.obolibrary.org/obo/GO_0140673 GO:0032959 biolink:BiologicalProcess inositol trisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. go.json IP3 biosynthesis|IP3 biosynthetic process|inositol trisphosphate anabolism|inositol trisphosphate biosynthesis|inositol trisphosphate formation|inositol trisphosphate synthesis|myo-inositol trisphosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0032959 GO:0032958 biolink:BiologicalProcess inositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. go.json inositol phosphate anabolism|inositol phosphate biosynthesis|inositol phosphate formation|inositol phosphate synthesis|myo-inositol phosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0032958 GO:0032957 biolink:BiologicalProcess inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. go.json IP3 metabolic process|IP3 metabolism|inositol trisphosphate metabolism|myo-inositol trisphosphate metabolic process http://purl.obolibrary.org/obo/GO_0032957 GO:0032956 biolink:BiologicalProcess regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. go.json regulation of actin cytoskeleton organisation|regulation of actin cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0032956 GO:0032955 biolink:BiologicalProcess regulation of division septum assembly Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. go.json regulation of division septum formation http://purl.obolibrary.org/obo/GO_0032955 GO:0032954 biolink:BiologicalProcess regulation of cytokinetic process Any process that modulates the frequency, rate or extent of a cytokinetic process. go.json http://purl.obolibrary.org/obo/GO_0032954 GO:0032953 biolink:BiologicalProcess regulation of (1->3)-beta-D-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans. go.json regulation of 1,3-beta-glucan anabolism|regulation of 1,3-beta-glucan biosynthesis|regulation of 1,3-beta-glucan biosynthetic process|regulation of 1,3-beta-glucan formation|regulation of 1,3-beta-glucan synthesis http://purl.obolibrary.org/obo/GO_0032953 GO:0032952 biolink:BiologicalProcess regulation of (1->3)-beta-D-glucan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans. go.json regulation of (1->3)-beta-D-glucan metabolism|regulation of 1,3-beta-D-glucan metabolic process|regulation of 1,3-beta-glucan metabolic process|regulation of 1,3-beta-glucan metabolism http://purl.obolibrary.org/obo/GO_0032952 GO:0032951 biolink:BiologicalProcess regulation of beta-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans. go.json regulation of beta-glucan anabolism|regulation of beta-glucan biosynthesis|regulation of beta-glucan formation|regulation of beta-glucan synthesis http://purl.obolibrary.org/obo/GO_0032951 GO:0032950 biolink:BiologicalProcess regulation of beta-glucan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans. go.json regulation of beta-glucan metabolism http://purl.obolibrary.org/obo/GO_0032950 GO:0032948 biolink:BiologicalProcess regulation of alpha-glucan metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans. go.json regulation of alpha-glucan metabolism http://purl.obolibrary.org/obo/GO_0032948 GO:0032947 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032947 GO:0032946 biolink:BiologicalProcess positive regulation of mononuclear cell proliferation Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. go.json activation of mononuclear cell proliferation|positive regulation of PBMC proliferation|positive regulation of peripheral blood mononuclear cell proliferation|stimulation of mononuclear cell proliferation|up regulation of mononuclear cell proliferation|up-regulation of mononuclear cell proliferation|upregulation of mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0032946 GO:0032945 biolink:BiologicalProcess negative regulation of mononuclear cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. go.json negative regulation of PBMC proliferation|negative regulation of peripheral blood mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0032945 GO:0032944 biolink:BiologicalProcess regulation of mononuclear cell proliferation Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. go.json regulation of PBMC proliferation|regulation of peripheral blood mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0032944 GO:0032943 biolink:BiologicalProcess mononuclear cell proliferation The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. go.json PBMC proliferation|peripheral blood mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0032943 GO:0032942 biolink:MolecularActivity inositol tetrakisphosphate 2-kinase activity Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP. go.json 1D-myo-inositol-tetrakisphosphate 2-kinase activity|inositol 1,3,4,6-tetrakisphosphate 2-kinase activity|inositol-tetrakisphosphate 2-kinase activity http://purl.obolibrary.org/obo/GO_0032942 GO:0032941 biolink:BiologicalProcess secretion by tissue The controlled release of a substance by a tissue. go.json expulsion of gland contents|tissue secretion http://purl.obolibrary.org/obo/GO_0032941 GO:0032949 biolink:BiologicalProcess regulation of alpha-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans. go.json regulation of alpha-glucan anabolism|regulation of alpha-glucan biosynthesis|regulation of alpha-glucan formation|regulation of alpha-glucan synthesis http://purl.obolibrary.org/obo/GO_0032949 GO:0032940 biolink:BiologicalProcess secretion by cell The controlled release of a substance by a cell. Wikipedia:Secretion go.json cellular secretion http://purl.obolibrary.org/obo/GO_0032940 GO:0150093 biolink:BiologicalProcess amyloid-beta clearance by transcytosis The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier. go.json http://purl.obolibrary.org/obo/GO_0150093 GO:0032937 biolink:CellularComponent SREBP-SCAP-Insig complex A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane. go.json http://purl.obolibrary.org/obo/GO_0032937 GO:0150092 biolink:BiologicalProcess regulation of synaptic scaling A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell. go.json homeostatic synaptic scaling|regulation of homeostatic synaptic scaling http://purl.obolibrary.org/obo/GO_0150092 GO:0032936 biolink:CellularComponent SREBP-SCAP complex A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. go.json Sre1-Scp1 complex http://purl.obolibrary.org/obo/GO_0032936 GO:0032935 biolink:MolecularActivity sterol sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol. go.json sterol sensing activity|sterol-sensing domain http://purl.obolibrary.org/obo/GO_0032935 GO:0150091 biolink:BiologicalProcess multiple spine synapse organization, multiple dendrites A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites. go.json http://purl.obolibrary.org/obo/GO_0150091 GO:0032934 biolink:MolecularActivity sterol binding Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. go.json sterol carrier activity http://purl.obolibrary.org/obo/GO_0032934 GO:0150090 biolink:BiologicalProcess multiple spine synapse organization, single dendrite A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite. go.json http://purl.obolibrary.org/obo/GO_0150090 GO:0032933 biolink:BiologicalProcess SREBP signaling pathway The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription. go.json ER to nucleus sterol response pathway|ER-nuclear sterol response pathway|SREBP signalling|SREBP target gene transcriptional activation|SREBP-mediated signaling pathway|SREBP-mediated signalling pathway|activation of sterol regulatory element binding protein target gene transcription|endoplasmic reticulum to nucleus sterol response pathway|endoplasmic reticulum-nuclear sterol response pathway|positive regulation of sterol regulatory element binding protein target gene transcription|positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response|positive regulation of transcription via sterol regulatory element binding|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway|sterol depletion response, SREBP target gene transcriptional activation|sterol regulatory element binding protein target gene transcriptional activation|sterol response element binding protein signaling pathway|stimulation of sterol regulatory element binding protein target gene transcription|up regulation of sterol regulatory element binding protein target gene transcription|up-regulation of sterol regulatory element binding protein target gene transcription|upregulation of sterol regulatory element binding protein target gene transcription http://purl.obolibrary.org/obo/GO_0032933 GO:0032932 biolink:BiologicalProcess negative regulation of astral microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules. go.json astral microtubule stabilization http://purl.obolibrary.org/obo/GO_0032932 GO:0032931 biolink:MolecularActivity histone H3K56 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56). go.json histone H3-K56 acetyltransferase activity|histone acetylase activity (H3-K56 specific)|histone acetyltransferase activity (H3-K56 specific)|histone lysine N-acetyltransferase activity (H3-K56 specific) http://purl.obolibrary.org/obo/GO_0032931 GO:0032930 biolink:BiologicalProcess positive regulation of superoxide anion generation Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell. go.json activation of superoxide release|positive regulation of superoxide release|stimulation of superoxide release|up regulation of superoxide release|up-regulation of superoxide release|upregulation of superoxide release http://purl.obolibrary.org/obo/GO_0032930 GO:0150099 biolink:BiologicalProcess neuron-glial cell signaling Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. go.json neuron-glia signaling|neuron-glia signalling|neuron-glial cell signalling|neurone-glia signaling|neurone-glia signalling|neurone-glial cell signaling|neurone-glial cell signalling http://purl.obolibrary.org/obo/GO_0150099 GO:0150098 biolink:BiologicalProcess glial cell-neuron signaling Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. go.json glia-neuron signaling|glia-neuron signalling|glia-neurone signaling|glia-neurone signalling|glial cell- neuron signalling|glial cell-neurone signalling|glial cell-neurone singaling http://purl.obolibrary.org/obo/GO_0150098 GO:0032939 biolink:BiologicalProcess positive regulation of translation in response to oxidative stress Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json activation of translation in response to oxidative stress|stimulation of translation in response to oxidative stress|up regulation of translation in response to oxidative stress|up-regulation of translation in response to oxidative stress|upregulation of translation in response to oxidative stress http://purl.obolibrary.org/obo/GO_0032939 GO:0032938 biolink:BiologicalProcess negative regulation of translation in response to oxidative stress Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. go.json http://purl.obolibrary.org/obo/GO_0032938 GO:0150094 biolink:BiologicalProcess amyloid-beta clearance by cellular catabolic process The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation. go.json amyloid-beta clearance by phagocytosis http://purl.obolibrary.org/obo/GO_0150094 GO:0032926 biolink:BiologicalProcess negative regulation of activin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway. go.json down regulation of activin receptor signaling pathway|down-regulation of activin receptor signaling pathway|downregulation of activin receptor signaling pathway|inhibition of activin receptor signaling pathway|negative regulation of activin receptor signalling pathway|negative regulation of activin signaling pathway|negative regulation of activin signalling pathway http://purl.obolibrary.org/obo/GO_0032926 GO:0032925 biolink:BiologicalProcess regulation of activin receptor signaling pathway Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. go.json regulation of activin receptor signalling pathway|regulation of activin signaling pathway|regulation of activin signalling pathway http://purl.obolibrary.org/obo/GO_0032925 GO:0032924 biolink:BiologicalProcess activin receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0032924 GO:0032923 biolink:BiologicalProcess organic phosphonate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. go.json organophosphonate biosynthetic process http://purl.obolibrary.org/obo/GO_0032923 GO:0032922 biolink:BiologicalProcess circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. go.json circadian regulation of protein expression|diurnal variation of gene expression|diurnal variation of protein expression http://purl.obolibrary.org/obo/GO_0032922 GO:0032921 biolink:CellularComponent sarcosine oxidase complex A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity. go.json http://purl.obolibrary.org/obo/GO_0032921 GO:0032920 biolink:BiologicalProcess putrescine acetylation The modification of putrescine by addition of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0032920 GO:0032929 biolink:BiologicalProcess negative regulation of superoxide anion generation Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell. go.json down regulation of superoxide release|down-regulation of superoxide release|downregulation of superoxide release|inhibition of superoxide release|negative regulation of superoxide release http://purl.obolibrary.org/obo/GO_0032929 GO:0032928 biolink:BiologicalProcess regulation of superoxide anion generation Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. go.json regulation of superoxide release http://purl.obolibrary.org/obo/GO_0032928 GO:0032927 biolink:BiologicalProcess positive regulation of activin receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway. go.json activation of activin receptor signaling pathway|positive regulation of activin receptor signalling pathway|positive regulation of activin signaling pathway|positive regulation of activin signalling pathway|stimulation of activin receptor signaling pathway|up regulation of activin receptor signaling pathway|up-regulation of activin receptor signaling pathway|upregulation of activin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0032927 GO:0032915 biolink:BiologicalProcess positive regulation of transforming growth factor beta2 production Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2. go.json activation of transforming growth factor-beta2 production|positive regulation of TGF-B2 production|positive regulation of TGFB2 production|positive regulation of transforming growth factor-beta2 production|stimulation of transforming growth factor-beta2 production|up regulation of transforming growth factor-beta2 production|up-regulation of transforming growth factor-beta2 production|upregulation of transforming growth factor-beta2 production http://purl.obolibrary.org/obo/GO_0032915 GO:0150071 biolink:BiologicalProcess negative regulation of arginase activity Any process that stops, prevents or reduces the frequency, rate or extent of arginase activity. go.json http://purl.obolibrary.org/obo/GO_0150071 gocheck_do_not_annotate GO:0032914 biolink:BiologicalProcess positive regulation of transforming growth factor beta1 production Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1. go.json activation of transforming growth factor-beta1 production|positive regulation of TGF-B1 production|positive regulation of TGFB1 production|stimulation of transforming growth factor-beta1 production|up regulation of transforming growth factor-beta1 production|up-regulation of transforming growth factor-beta1 production|upregulation of transforming growth factor-beta1 production http://purl.obolibrary.org/obo/GO_0032914 GO:0150070 biolink:BiologicalProcess regulation of arginase activity Any process that modulates the frequency, rate or extent of arginase activity. go.json http://purl.obolibrary.org/obo/GO_0150070 gocheck_do_not_annotate GO:0032913 biolink:BiologicalProcess negative regulation of transforming growth factor beta3 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3. go.json down regulation of transforming growth factor-beta3 production|down-regulation of transforming growth factor-beta3 production|downregulation of transforming growth factor-beta3 production|inhibition of transforming growth factor-beta3 production|negative regulation of TGF-B3 production|negative regulation of TGFB3 production|negative regulation of transforming growth factor-beta3 production http://purl.obolibrary.org/obo/GO_0032913 GO:0032912 biolink:BiologicalProcess negative regulation of transforming growth factor beta2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2. go.json down regulation of transforming growth factor-beta2 production|down-regulation of transforming growth factor-beta2 production|downregulation of transforming growth factor-beta2 production|inhibition of transforming growth factor-beta2 production|negative regulation of TGF-B2 production|negative regulation of TGFB2 production|negative regulation of transforming growth factor-beta2 production http://purl.obolibrary.org/obo/GO_0032912 GO:0032911 biolink:BiologicalProcess negative regulation of transforming growth factor beta1 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1. go.json down regulation of transforming growth factor-beta1 production|down-regulation of transforming growth factor-beta1 production|downregulation of transforming growth factor-beta1 production|inhibition of transforming growth factor-beta1 production|negative regulation of TGF-B1 production|negative regulation of TGFB1 production|negative regulation of transforming growth factor-beta1 production http://purl.obolibrary.org/obo/GO_0032911 GO:0032910 biolink:BiologicalProcess regulation of transforming growth factor beta3 production Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3. go.json regulation of TGF-B3 production|regulation of TGFB3 production|regulation of transforming growth factor-beta3 production http://purl.obolibrary.org/obo/GO_0032910 GO:0150079 biolink:BiologicalProcess negative regulation of neuroinflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. go.json http://purl.obolibrary.org/obo/GO_0150079 GO:0150078 biolink:BiologicalProcess positive regulation of neuroinflammatory response Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. go.json http://purl.obolibrary.org/obo/GO_0150078 GO:0150077 biolink:BiologicalProcess regulation of neuroinflammatory response Any process that modulates the frequency, rate or extent of neuroinflammatory response. go.json http://purl.obolibrary.org/obo/GO_0150077 GO:0150076 biolink:BiologicalProcess neuroinflammatory response The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. go.json nerve tissue inflammatory response|nervous tissue inflammatory response|neural tissue inflammatory response http://purl.obolibrary.org/obo/GO_0150076 GO:0150075 biolink:BiologicalProcess negative regulation of protein-glutamine gamma-glutamyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0150075 gocheck_do_not_annotate GO:0032919 biolink:BiologicalProcess spermine acetylation The modification of spermine by addition of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0032919 GO:0032918 biolink:BiologicalProcess spermidine acetylation The modification of spermidine by addition of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0032918 GO:0150074 biolink:BiologicalProcess positive regulation of protein-glutamine gamma-glutamyltransferase activity Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0150074 gocheck_do_not_annotate GO:0150073 biolink:BiologicalProcess regulation of protein-glutamine gamma-glutamyltransferase activity Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0150073 gocheck_do_not_annotate GO:0032917 biolink:BiologicalProcess polyamine acetylation The modification of polyamines by addition of acetyl groups. go.json http://purl.obolibrary.org/obo/GO_0032917 GO:0150072 biolink:BiologicalProcess positive regulation of arginase activity Any process that activates or increases the frequency, rate or extent of arginase activity. go.json http://purl.obolibrary.org/obo/GO_0150072 gocheck_do_not_annotate GO:0032916 biolink:BiologicalProcess positive regulation of transforming growth factor beta3 production Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3. go.json activation of transforming growth factor-beta3 production|positive regulation of TGF-B3 production|positive regulation of TGFB3 production|positive regulation of transforming growth factor-beta3 production|stimulation of transforming growth factor-beta3 production|up regulation of transforming growth factor-beta3 production|up-regulation of transforming growth factor-beta3 production|upregulation of transforming growth factor-beta3 production http://purl.obolibrary.org/obo/GO_0032916 GO:0032904 biolink:BiologicalProcess negative regulation of nerve growth factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF). go.json down regulation of nerve growth factor production|down-regulation of nerve growth factor production|downregulation of nerve growth factor production|inhibition of nerve growth factor production|negative regulation of NGF production http://purl.obolibrary.org/obo/GO_0032904 GO:0032903 biolink:BiologicalProcess regulation of nerve growth factor production Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF). go.json regulation of NGF production|regulation of beta-nerve growth factor production http://purl.obolibrary.org/obo/GO_0032903 GO:0032902 biolink:BiologicalProcess nerve growth factor production The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. go.json NGF production|beta-nerve growth factor production http://purl.obolibrary.org/obo/GO_0032902 GO:0032901 biolink:BiologicalProcess positive regulation of neurotrophin production Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin. go.json activation of neurotrophin production|stimulation of neurotrophin production|up regulation of neurotrophin production|up-regulation of neurotrophin production|upregulation of neurotrophin production http://purl.obolibrary.org/obo/GO_0032901 GO:0032900 biolink:BiologicalProcess negative regulation of neurotrophin production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin. go.json down regulation of neurotrophin production|down-regulation of neurotrophin production|downregulation of neurotrophin production|inhibition of neurotrophin production http://purl.obolibrary.org/obo/GO_0032900 GO:0150089 biolink:BiologicalProcess multiple spine synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines. go.json multi-synapse organisation|multi-synapse organization|multi-synaptic organisation|multi-synaptic organization|multiple spine synapse organisation|multisynapse organisation|multisynapse organization|multisynaptic organisation|multisynaptic organization http://purl.obolibrary.org/obo/GO_0150089 GO:0150088 biolink:CellularComponent multiple synapse bouton, contacting multiple dendrites A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites. go.json MSB2|type 2 multi-synapse bouton|type 2 multi-synaptic bouton|type 2 multiple spine synapse bouton|type 2 multiple-synapse bouton|type 2 multisynapse bouton|type 2 multisynaptic bouton http://purl.obolibrary.org/obo/GO_0150088 GO:0150087 biolink:CellularComponent multiple synapse bouton, contacting single dendrite A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite. go.json MSB1|type 1 multi-synapse bouton|type 1 multi-synaptic bouton|type 1 multiple spine synapse bouton|type 1 multiple-synapse bouton|type 1 multisynapse bouton|type 1 multisynaptic bouton http://purl.obolibrary.org/obo/GO_0150087 GO:0032909 biolink:BiologicalProcess regulation of transforming growth factor beta2 production Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2. go.json regulation of TGF-B2 production|regulation of TGFB2 production|regulation of transforming growth factor-beta2 production http://purl.obolibrary.org/obo/GO_0032909 GO:0032908 biolink:BiologicalProcess regulation of transforming growth factor beta1 production Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1. go.json regulation of TGF-B1 production|regulation of TGFB1 production|regulation of transforming growth factor-beta1 production http://purl.obolibrary.org/obo/GO_0032908 GO:0150086 biolink:CellularComponent multiple synapse bouton A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites. go.json MSB|multi-synapse|multi-synapse bouton|multi-synaptic bouton|multiple spine synapse bouton|multiple synapse|multiple-synapse bouton|multisynapse|multisynapse bouton|multisynaptic bouton http://purl.obolibrary.org/obo/GO_0150086 GO:0032907 biolink:BiologicalProcess transforming growth factor beta3 production The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json TGF-B3 production|TGFB3 production|transforming growth factor-beta3 production http://purl.obolibrary.org/obo/GO_0032907 GO:0032906 biolink:BiologicalProcess transforming growth factor beta2 production The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json TGF-B2 production|TGFB2 production|transforming growth factor-beta2 production http://purl.obolibrary.org/obo/GO_0032906 GO:0032905 biolink:BiologicalProcess transforming growth factor beta1 production The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json TGF-B1 production|TGFB1 production|transforming growth factor-beta1 production http://purl.obolibrary.org/obo/GO_0032905 GO:0150057 biolink:CellularComponent amylin receptor complex 2 A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM). go.json AMY2 complex http://purl.obolibrary.org/obo/GO_0150057 GO:0150056 biolink:CellularComponent amylin receptor complex 1 A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). go.json AMY1 complex http://purl.obolibrary.org/obo/GO_0150056 GO:0150054 biolink:BiologicalProcess regulation of postsynaptic neurotransmitter receptor diffusion trapping Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping. go.json http://purl.obolibrary.org/obo/GO_0150054 goslim_synapse GO:0150053 biolink:CellularComponent cerebellar climbing fiber to Purkinje cell synapse A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. go.json cerebellar climbing fibre to Purkinje cell synapse http://purl.obolibrary.org/obo/GO_0150053 goslim_synapse GO:0150052 biolink:BiologicalProcess regulation of postsynapse assembly Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. go.json http://purl.obolibrary.org/obo/GO_0150052 goslim_synapse GO:0150051 biolink:CellularComponent postsynaptic Golgi apparatus The network of the Golgi apparatus structures located within the postsynapse. go.json Golgi outpost http://purl.obolibrary.org/obo/GO_0150051 goslim_synapse GO:0150050 biolink:CellularComponent postsynaptic septin cytoskeleton The portion of the septin cytoskeleton contained within the postsynapse. go.json http://purl.obolibrary.org/obo/GO_0150050 goslim_synapse GO:0150059 biolink:BiologicalProcess amylin receptor 1 signaling pathway The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). go.json AMY1 signaling pathway http://purl.obolibrary.org/obo/GO_0150059 GO:0150058 biolink:CellularComponent amylin receptor complex 3 A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signaling pathways. go.json AMY3 complex http://purl.obolibrary.org/obo/GO_0150058 GO:0150060 biolink:BiologicalProcess amylin receptor 2 signaling pathway The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM). go.json AMY2 signaling pathway http://purl.obolibrary.org/obo/GO_0150060 GO:0150068 biolink:BiologicalProcess positive regulation of tubulin deacetylase activity Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity. go.json http://purl.obolibrary.org/obo/GO_0150068 gocheck_do_not_annotate GO:0150067 biolink:BiologicalProcess regulation of tubulin deacetylase activity Any process that modulates the frequency, rate or extent of tubulin deacetylase activity. go.json http://purl.obolibrary.org/obo/GO_0150067 gocheck_do_not_annotate GO:0150066 biolink:BiologicalProcess negative regulation of deacetylase activity Any process that stops, prevents or reduces the frequency, rate or extent of deacetylase activity. go.json http://purl.obolibrary.org/obo/GO_0150066 gocheck_do_not_annotate GO:0150065 biolink:BiologicalProcess regulation of deacetylase activity Any process that modulates the frequency, rate or extent of deacetylase activity. go.json http://purl.obolibrary.org/obo/GO_0150065 gocheck_do_not_annotate GO:0150064 biolink:BiologicalProcess vertebrate eye-specific patterning Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus. go.json binocular vision development|eye-specific patterning|eye-specific segregation|vertebrate eye-specific segregation http://purl.obolibrary.org/obo/GO_0150064 GO:0150063 biolink:BiologicalProcess visual system development The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. go.json optic pathway development|visual pathway development http://purl.obolibrary.org/obo/GO_0150063 GO:0150062 biolink:BiologicalProcess complement-mediated synapse pruning Synaptic pruning mediated by complement system signaling. go.json complement-dependent synapse pruning|synapse clearance|synapse disassembly|synapse elimination|synapse removal http://purl.obolibrary.org/obo/GO_0150062 GO:0150061 biolink:BiologicalProcess amylin receptor 3 signaling pathway The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos. go.json AMY3 signaling pathway http://purl.obolibrary.org/obo/GO_0150061 GO:0150069 biolink:BiologicalProcess negative regulation of tubulin deacetylase activity Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity. go.json http://purl.obolibrary.org/obo/GO_0150069 gocheck_do_not_annotate GO:0140904 biolink:BiologicalProcess cytoophidium organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a cytoophidium. Cytoophidia are mesoscale, intracellular, filamentous structures that contain metabolic enzymes. go.json http://purl.obolibrary.org/obo/GO_0140904 GO:0140903 biolink:MolecularActivity histone H3R26 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3. go.json histone H3R26 arginine methyltransferase activity|histone methylase activity (H3-R26 specific)|histone methyltransferase activity (H3-R26 specific)|histone-H3R26 methyltransferase activity|histone-arginine N-methyltransferase activity (H3-R26 specific) http://purl.obolibrary.org/obo/GO_0140903 GO:0140906 biolink:MolecularActivity halogenase activity Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O. go.json http://purl.obolibrary.org/obo/GO_0140906 GO:0042480 biolink:BiologicalProcess negative regulation of eye photoreceptor cell development Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. go.json down regulation of eye photoreceptor cell development|down-regulation of eye photoreceptor cell development|downregulation of eye photoreceptor cell development|inhibition of eye photoreceptor cell development|negative regulation of eye photoreceptor development http://purl.obolibrary.org/obo/GO_0042480 GO:0140905 biolink:MolecularActivity haloperoxidase activity Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O. go.json http://purl.obolibrary.org/obo/GO_0140905 GO:0140908 biolink:MolecularActivity histone H3K122 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122). go.json histone H3-K122 acetyltransferase activity|histone acetylase activity (H3-K122 specific)|histone acetyltransferase activity (H3-K122 specific)|histone lysine N-acetyltransferase activity (H3-K122 specific) http://purl.obolibrary.org/obo/GO_0140908 GO:0140907 biolink:MolecularActivity flavin-dependent halogenase activity Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O. go.json http://purl.obolibrary.org/obo/GO_0140907 GO:0140909 biolink:BiologicalProcess kinetoplast DNA replication The process of doubling of the number of maxicircles and minicircles and distribution of the progeny into two daughter networks, which are identical to the parent kinetoplast DNA network. go.json kDNA replication|kinetoplast DNA synthesis|replication of kinetoplast DNA http://purl.obolibrary.org/obo/GO_0140909 GO:0042486 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042486 GO:0042485 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042485 GO:0042488 biolink:BiologicalProcess positive regulation of odontogenesis of dentin-containing tooth Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. go.json activation of odontogenesis|positive regulation of odontogenesis of dentine-containing teeth|positive regulation of odontogenesis of dentine-containing tooth|stimulation of odontogenesis|up regulation of odontogenesis|up-regulation of odontogenesis|upregulation of odontogenesis http://purl.obolibrary.org/obo/GO_0042488 GO:0042487 biolink:BiologicalProcess regulation of odontogenesis of dentin-containing tooth Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. go.json regulation of odontogenesis of dentine-containing teeth|regulation of odontogenesis of dentine-containing tooth http://purl.obolibrary.org/obo/GO_0042487 GO:0042482 biolink:BiologicalProcess positive regulation of odontogenesis Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth. go.json activation of odontogenesis|positive regulation of odontogenesis of calcareous or chitinous tooth|positive regulation of tooth development|stimulation of odontogenesis|up regulation of odontogenesis|up-regulation of odontogenesis|upregulation of odontogenesis http://purl.obolibrary.org/obo/GO_0042482 GO:0140900 biolink:MolecularActivity chloride:bicarbonate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in). RHEA:72203|TC:2.A.53.2.18 go.json bicarbonate:chloride antiporter activity http://purl.obolibrary.org/obo/GO_0140900 GO:0042481 biolink:BiologicalProcess regulation of odontogenesis Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. go.json regulation of odontogenesis of calcareous or chitinous tooth|regulation of tooth development http://purl.obolibrary.org/obo/GO_0042481 GO:0042484 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042484 GO:0140902 biolink:MolecularActivity L-glutamine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in). TC:2.A.18.6.13 go.json glutamine:sodium symporter activity|sodium:L-glutamine symporter activity|sodium:glutamine symporter activity http://purl.obolibrary.org/obo/GO_0140902 GO:0042483 biolink:BiologicalProcess negative regulation of odontogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth. go.json down regulation of odontogenesis|down-regulation of odontogenesis|downregulation of odontogenesis|inhibition of odontogenesis|negative regulation of odontogenesis of calcareous or chitinous tooth|negative regulation of tooth development http://purl.obolibrary.org/obo/GO_0042483 GO:0140901 biolink:MolecularActivity L-asparagine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in). RHEA:71383|TC:2.A.18.6.13 go.json asparagine:sodium symporter activity|sodium:L-asparagine symporter activity|sodium:asparagine symporter activity http://purl.obolibrary.org/obo/GO_0140901 GO:0042489 biolink:BiologicalProcess negative regulation of odontogenesis of dentin-containing tooth Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx. go.json down regulation of odontogenesis|down-regulation of odontogenesis|downregulation of odontogenesis|inhibition of odontogenesis|negative regulation of odontogenesis|negative regulation of odontogenesis of dentine-containing teeth|negative regulation of odontogenesis of dentine-containing tooth http://purl.obolibrary.org/obo/GO_0042489 GO:0042491 biolink:BiologicalProcess inner ear auditory receptor cell differentiation The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell. go.json auditory hair cell differentiation|auditory receptor cell differentiation http://purl.obolibrary.org/obo/GO_0042491 GO:0042490 biolink:BiologicalProcess mechanoreceptor differentiation The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. go.json http://purl.obolibrary.org/obo/GO_0042490 GO:0042497 biolink:MolecularActivity triacyl lipopeptide binding Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups. go.json bacterial triacyl lipopeptide binding|bacterial triacyl lipoprotein binding|triacylated lipopeptide binding http://purl.obolibrary.org/obo/GO_0042497 GO:0042496 biolink:BiologicalProcess detection of diacyl bacterial lipopeptide The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups. go.json detection of diacylated bacterial lipoprotein|perception of diacylated bacterial lipopeptide|perception of diacylated bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0042496 GO:0042499 biolink:MolecularActivity obsolete signal peptide peptidase activity OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein. go.json SPP|signal peptide peptidase activity True http://purl.obolibrary.org/obo/GO_0042499 GO:0042498 biolink:MolecularActivity diacyl lipopeptide binding Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups. go.json bacterial diacyl lipopeptide binding|bacterial diacyl lipoprotein binding|diacylated lipopeptide binding http://purl.obolibrary.org/obo/GO_0042498 GO:0042493 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042493 GO:0042492 biolink:BiologicalProcess gamma-delta T cell differentiation The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex. go.json gamma-delta T cell development|gamma-delta T lymphocyte differentiation|gamma-delta T-cell differentiation|gamma-delta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0042492 GO:0042495 biolink:BiologicalProcess detection of triacyl bacterial lipopeptide The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups. go.json detection of triacylated bacterial lipoprotein|perception of triacylated bacterial lipopeptide|perception of triacylated bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0042495 GO:0042494 biolink:BiologicalProcess detection of bacterial lipoprotein The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). go.json detection of BLP|detection of Lpp|perception of BLP|perception of Lpp|perception of bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0042494 GO:0140926 biolink:MolecularActivity L-kynurenine transmembrane transporter activity Enables the transfer of L-kynurenine from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0140926 GO:0140925 biolink:BiologicalProcess L-phenylalanine import across plasma membrane The directed movement of L-phenylalanine from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140925 GO:0140928 biolink:BiologicalProcess inhibition of non-skeletal tissue mineralization A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue. go.json inhibition of ectopic tissue mineralization http://purl.obolibrary.org/obo/GO_0140928 GO:0140927 biolink:MolecularActivity cyclic-di-GMP transmembrane transporter activity Enables the transfer of cyclic-di-GMP from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0140927 GO:0140929 biolink:MolecularActivity mannose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in). go.json http://purl.obolibrary.org/obo/GO_0140929 GO:0140920 biolink:BiologicalProcess regulation of thermomorphogenesis Any process that modulates the frequency, rate or extent of thermomorphogenesis. go.json http://purl.obolibrary.org/obo/GO_0140920 GO:0140922 biolink:BiologicalProcess positive regulation of thermomorphogenesis Any process that increases the rate, frequency or extent of thermomorphogenesis. go.json http://purl.obolibrary.org/obo/GO_0140922 GO:0140921 biolink:BiologicalProcess negative regulation of thermomorphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of thermomorphogenesis. go.json http://purl.obolibrary.org/obo/GO_0140921 GO:0140924 biolink:BiologicalProcess L-kynurenine transmembrane transport The directed movement of L-kynurenine across a membrane. go.json http://purl.obolibrary.org/obo/GO_0140924 GO:0140923 biolink:BiologicalProcess magnetosome assembly The aggregation, arrangement and bonding together of a set of components to form a magnetosome. Magnetosomes are specialized organelles for magnetic navigation that comprise membrane-enveloped, nano-sized crystals of a magnetic iron mineral; they are formed by a diverse group of magnetotactic bacteria (MTB). go.json magnetosome formation http://purl.obolibrary.org/obo/GO_0140923 GO:0140915 biolink:BiologicalProcess zinc ion import into zymogen granule The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a zymogen granule. go.json http://purl.obolibrary.org/obo/GO_0140915 GO:0140914 biolink:BiologicalProcess zinc ion import into secretory vesicle The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a secretory vesicle. go.json http://purl.obolibrary.org/obo/GO_0140914 GO:0140917 biolink:BiologicalProcess zinc ion import into mitochondrion The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0140917 GO:0140916 biolink:BiologicalProcess zinc ion import into lysosome The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a lysosome. go.json http://purl.obolibrary.org/obo/GO_0140916 GO:0140919 biolink:BiologicalProcess thermomorphogenesis The suite of morphological and architectural changes in an organism induced by high ambient temperatures, below the heat-stress range. go.json http://purl.obolibrary.org/obo/GO_0140919 GO:0140918 biolink:CellularComponent centrosomal core The core region of the centrosome, a layered structure containing proteins, surrounded by the centrosomal corona. The core duplicates once per cell cycle at the G2/M transition when two outer layers form the mitotic spindle poles. go.json centrosome core http://purl.obolibrary.org/obo/GO_0140918 GO:0140911 biolink:MolecularActivity pore-forming activity An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death. TC:1.C go.json canonical holin activity|holin activity|pinholin activity|pore forming activity http://purl.obolibrary.org/obo/GO_0140911 GO:0140910 biolink:CellularComponent iRhom2/ADAM17 sheddase complex A complex consisting of ADAM17 in complex with regulatory iRhoms and FERM domain containing proteins. go.json http://purl.obolibrary.org/obo/GO_0140910 GO:0140913 biolink:BiologicalProcess viral release via disruption of host peptidoglycan cell wall The dissemination of mature viral particles from a host cell, caused by a virus hydrolyzing the peptidoglycan cell wall of the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. go.json http://purl.obolibrary.org/obo/GO_0140913 GO:0140912 biolink:MolecularActivity membrane destabilizing activity Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release. go.json antimicrobial peptide http://purl.obolibrary.org/obo/GO_0140912 GO:0140984 biolink:MolecularActivity histone H4K12 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein. go.json histone H4 lysine 12-specific methyltransferase activity|histone H4K12 methylase activity|histone H4K12 methylation|histone lysine N-methyltransferase activity (H4-K12 specific)|histone methylase activity (H4-K12 specific)|histone methyltransferase activity (H4-K12 specific)|histone-H4K12 methyltransferase activity http://purl.obolibrary.org/obo/GO_0140984 GO:0140983 biolink:MolecularActivity calcium:manganese antiporter activity Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in). RHEA:73059 go.json manganese:calcium antiporter activity http://purl.obolibrary.org/obo/GO_0140983 GO:0140986 biolink:BiologicalProcess G protein-coupled chemorepellent receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization. go.json http://purl.obolibrary.org/obo/GO_0140986 GO:0042400 biolink:BiologicalProcess ectoine catabolic process The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. go.json ectoine breakdown|ectoine catabolism|ectoine degradation http://purl.obolibrary.org/obo/GO_0042400 GO:0140985 biolink:MolecularActivity G protein-coupled chemorepellent receptor activity Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein chemorepellent receptor activity|G-protein chemorepellent receptor activity|G-protein coupled chemorepellent receptor activity http://purl.obolibrary.org/obo/GO_0140985 GO:0140988 biolink:MolecularActivity ADP:inorganic phosphate antiporter activity Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + inorganic phosphate(in) = ADP(in) + inorganic phosphate(out). RHEA:65844 go.json inorganic phosphate:ADP antiporter activity http://purl.obolibrary.org/obo/GO_0140988 GO:0140987 biolink:MolecularActivity ATP:inorganic phosphate antiporter activity Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + inorganic phosphate(in) = ATP(in) + inorganic phosphate(out). RHEA:65840 go.json inorganic phosphate:ATP antiporter activity http://purl.obolibrary.org/obo/GO_0140987 GO:0140989 biolink:MolecularActivity 7-deoxyloganate 7-hydroxylase activity Catalysis of the reaction: 7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganate + oxidized [NADPH-hemoprotein reductase]. EC:1.14.14.85|RHEA:57576 go.json http://purl.obolibrary.org/obo/GO_0140989 GO:0042406 biolink:CellularComponent extrinsic component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. go.json extrinsic to ER membrane|extrinsic to endoplasmic reticulum membrane http://purl.obolibrary.org/obo/GO_0042406 GO:0042405 biolink:CellularComponent nuclear inclusion body An intranuclear focus at which aggregated proteins have been sequestered. go.json http://purl.obolibrary.org/obo/GO_0042405 GO:0042408 biolink:MolecularActivity obsolete myrcene/(E)-beta-ocimene synthase activity OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes. EC:4.6.-.- go.json myrcene/(E)-beta-ocimene synthase activity|myrcene/ocimene synthase activity True http://purl.obolibrary.org/obo/GO_0042408 GO:0042407 biolink:BiologicalProcess cristae formation The assembly of cristae, the inwards folds of the inner mitochondrial membrane. go.json http://purl.obolibrary.org/obo/GO_0042407 GO:0140980 biolink:BiologicalProcess intracellular nucleoside homeostasis A homeostatic process involved in the maintenance of a steady state level of nucleosides within a cell. go.json http://purl.obolibrary.org/obo/GO_0140980 GO:0042402 biolink:BiologicalProcess cellular biogenic amine catabolic process The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. go.json biogenic amine breakdown|biogenic amine catabolism|biogenic amine degradation http://purl.obolibrary.org/obo/GO_0042402 GO:0042401 biolink:BiologicalProcess biogenic amine biosynthetic process The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. go.json biogenic amine anabolism|biogenic amine biosynthesis|biogenic amine formation|biogenic amine synthesis|cellular biogenic amine biosynthetic process http://purl.obolibrary.org/obo/GO_0042401 GO:0042404 biolink:BiologicalProcess thyroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. go.json thyroid hormone breakdown|thyroid hormone catabolism|thyroid hormone degradation http://purl.obolibrary.org/obo/GO_0042404 GO:0140982 biolink:BiologicalProcess detoxification of aluminum ion Any process that reduce or remove the toxicity of aluminum ions. These can include transport of the aluminum away from sensitive areas, sequesteration, or chemical modification to an inert form. go.json aluminum ion homeostasis http://purl.obolibrary.org/obo/GO_0140982 GO:0140981 biolink:MolecularActivity medium-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. MetaCyc:RXN-19719|RHEA:75279 go.json http://purl.obolibrary.org/obo/GO_0140981 GO:0042403 biolink:BiologicalProcess thyroid hormone metabolic process The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. go.json thyroid hormone metabolism http://purl.obolibrary.org/obo/GO_0042403 GO:0042409 biolink:MolecularActivity caffeoyl-CoA O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA. EC:2.1.1.104|MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN|RHEA:16925 go.json S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity|caffeoyl coenzyme A methyltransferase activity|caffeoyl-CoA 3-O-methyltransferase activity|trans-caffeoyl-CoA 3-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0042409 GO:0140973 biolink:BiologicalProcess positive regulation of AIM2 inflammasome complex assembly Any process that activates or increases the frequency, rate or extent of AIM2 inflammasome complex assembly. go.json http://purl.obolibrary.org/obo/GO_0140973 GO:0140972 biolink:BiologicalProcess negative regulation of AIM2 inflammasome complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of AIM2 inflammasome complex assembly. go.json http://purl.obolibrary.org/obo/GO_0140972 GO:0140975 biolink:BiologicalProcess disruption of cellular anatomical structure in another organism The disruption of a cellular component of another organism, leading to damage or temporary subversion of that structure. In some cases this can cause malfunctioning of the cells and death of the target organism. go.json disruption of cellular component of another organism http://purl.obolibrary.org/obo/GO_0140975 GO:0042411 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042411 GO:0042410 biolink:MolecularActivity 6-carboxyhexanoate-CoA ligase activity Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA. EC:6.2.1.14|KEGG_REACTION:R03209|MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN|RHEA:14781 go.json 6-carboxyhexanoate:CoA ligase (AMP-forming)|6-carboxyhexanoyl-CoA synthetase activity|pimeloyl-CoA synthetase activity|pimelyl-CoA synthetase activity http://purl.obolibrary.org/obo/GO_0042410 GO:0140974 biolink:BiologicalProcess cellular detoxification of sulfide Any process carried out at the cellular level that reduces or removes the toxicity of a sulfide. These may include chemical modification or transport of sulfide away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. go.json http://purl.obolibrary.org/obo/GO_0140974 GO:0140977 biolink:BiologicalProcess cellular detoxification of acetone Any process carried out at the cellular level that reduces or removes the toxicity of acetone. These may include chemical modification, for example to methylglyoxal. go.json http://purl.obolibrary.org/obo/GO_0140977 GO:0140976 biolink:BiologicalProcess defense response against perturbation of plasma membrane integrity The cellular processes and signaling pathways by which a cell responds to disruption of the integrity of its plasma membrane by another organism. Some toxins produced by other organisms can form pores in membranes, or affect the membrane permeability. go.json defense response against disruption of plasma membrane integrity http://purl.obolibrary.org/obo/GO_0140976 GO:0140979 biolink:BiologicalProcess intracellular nucleotide homeostasis A homeostatic process involved in the maintenance of a steady state level of nucleotides within a cell. go.json http://purl.obolibrary.org/obo/GO_0140979 GO:0140978 biolink:MolecularActivity mitochondrial large ribosomal subunit binding Binding to a mitochondrial large ribosomal subunit. go.json mitochondrial ribosomal large subunit binding http://purl.obolibrary.org/obo/GO_0140978 GO:0042417 biolink:BiologicalProcess dopamine metabolic process The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. go.json dopamine metabolism http://purl.obolibrary.org/obo/GO_0042417 GO:0042416 biolink:BiologicalProcess dopamine biosynthetic process The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. go.json dopamine anabolism|dopamine biosynthesis|dopamine formation|dopamine synthesis http://purl.obolibrary.org/obo/GO_0042416 GO:0042419 biolink:BiologicalProcess epinephrine catabolic process The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. go.json adrenaline catabolic process|adrenaline catabolism|epinephrine breakdown|epinephrine catabolism|epinephrine degradation http://purl.obolibrary.org/obo/GO_0042419 GO:0042418 biolink:BiologicalProcess epinephrine biosynthetic process The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. go.json adrenaline biosynthesis|adrenaline biosynthetic process|epinephrine anabolism|epinephrine biosynthesis|epinephrine formation|epinephrine synthesis http://purl.obolibrary.org/obo/GO_0042418 GO:0042413 biolink:BiologicalProcess carnitine catabolic process The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. go.json carnitine breakdown|carnitine catabolism|carnitine degradation|vitamin Bt catabolic process|vitamin Bt catabolism http://purl.obolibrary.org/obo/GO_0042413 GO:0042412 biolink:BiologicalProcess taurine biosynthetic process The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. go.json taurine anabolism|taurine biosynthesis|taurine formation|taurine synthesis http://purl.obolibrary.org/obo/GO_0042412 GO:0042415 biolink:BiologicalProcess norepinephrine metabolic process The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. go.json levarterenol metabolic process|levarterenol metabolism|noradrenaline metabolic process|noradrenaline metabolism|norepinephrine metabolism http://purl.obolibrary.org/obo/GO_0042415 GO:0140971 biolink:BiologicalProcess regulation of AIM2 inflammasome complex assembly Any process that modulates the frequency, rate or extent of AIM2 inflammasome complex assembly. go.json http://purl.obolibrary.org/obo/GO_0140971 GO:0140970 biolink:BiologicalProcess AIM2 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex. go.json http://purl.obolibrary.org/obo/GO_0140970 GO:0042414 biolink:BiologicalProcess epinephrine metabolic process The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. go.json adrenaline metabolic process|adrenaline metabolism|epinephrine metabolism http://purl.obolibrary.org/obo/GO_0042414 GO:0042420 biolink:BiologicalProcess dopamine catabolic process The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. go.json dopamine breakdown|dopamine catabolism|dopamine degradation http://purl.obolibrary.org/obo/GO_0042420 GO:0042422 biolink:BiologicalProcess norepinephrine catabolic process The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. Wikipedia:Norepinephrine#Degradation go.json levarterenol catabolic process|levarterenol catabolism|noradrenaline catabolic process|noradrenaline catabolism|norepinephrine breakdown|norepinephrine catabolism|norepinephrine degradation http://purl.obolibrary.org/obo/GO_0042422 GO:0042421 biolink:BiologicalProcess norepinephrine biosynthetic process The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. go.json levarterenol biosynthesis|levarterenol biosynthetic process|noradrenaline biosynthesis|noradrenaline biosynthetic process|norepinephrine anabolism|norepinephrine biosynthesis|norepinephrine formation|norepinephrine synthesis http://purl.obolibrary.org/obo/GO_0042421 GO:0042428 biolink:BiologicalProcess serotonin metabolic process The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. go.json serotonin metabolism http://purl.obolibrary.org/obo/GO_0042428 GO:0042427 biolink:BiologicalProcess serotonin biosynthetic process The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. Wikipedia:Serotonin go.json serotonin anabolism|serotonin biosynthesis|serotonin formation|serotonin synthesis http://purl.obolibrary.org/obo/GO_0042427 GO:0042429 biolink:BiologicalProcess serotonin catabolic process The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. go.json serotonin breakdown|serotonin catabolism|serotonin degradation http://purl.obolibrary.org/obo/GO_0042429 GO:0042424 biolink:BiologicalProcess catecholamine catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. go.json catecholamine breakdown|catecholamine catabolism|catecholamine degradation http://purl.obolibrary.org/obo/GO_0042424 GO:0042423 biolink:BiologicalProcess catecholamine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. Wikipedia:Catecholamines go.json catecholamine anabolism|catecholamine biosynthesis|catecholamine formation|catecholamine synthesis http://purl.obolibrary.org/obo/GO_0042423 GO:0042426 biolink:BiologicalProcess choline catabolic process The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. go.json choline breakdown|choline catabolism|choline degradation http://purl.obolibrary.org/obo/GO_0042426 GO:0042425 biolink:BiologicalProcess choline biosynthetic process The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. MetaCyc:PWY-4762 go.json choline anabolism|choline biosynthesis|choline formation|choline synthesis http://purl.obolibrary.org/obo/GO_0042425 GO:0140995 biolink:MolecularActivity histone H2A kinase activity Catalysis of the transfer of a phosphate group to a histone H2A. go.json http://purl.obolibrary.org/obo/GO_0140995 GO:0042431 biolink:BiologicalProcess indole metabolic process The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). go.json indole metabolism http://purl.obolibrary.org/obo/GO_0042431 GO:0140994 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat modifying activity A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity. go.json RNA polymerase II CTD repeat modifying activity|RNA polymerase II large subunit CTD heptapeptide repeat modifying activity http://purl.obolibrary.org/obo/GO_0140994 GO:0042430 biolink:BiologicalProcess indole-containing compound metabolic process The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. go.json indole and derivative metabolic process|indole and derivative metabolism|indole derivative metabolic process|indole derivative metabolism|indole-containing compound metabolism|ketole metabolic process|ketole metabolism http://purl.obolibrary.org/obo/GO_0042430 GO:0140997 biolink:MolecularActivity histone H4 kinase activity Catalysis of the transfer of a phosphate group to a histone H4. go.json http://purl.obolibrary.org/obo/GO_0140997 GO:0042433 biolink:BiologicalProcess indole catabolic process The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). go.json indole breakdown|indole catabolism|indole degradation http://purl.obolibrary.org/obo/GO_0042433 GO:0042432 biolink:BiologicalProcess indole biosynthetic process The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). go.json indole anabolism|indole biosynthesis|indole formation|indole synthesis http://purl.obolibrary.org/obo/GO_0042432 GO:0140996 biolink:MolecularActivity histone H3 kinase activity Catalysis of the transfer of a phosphate group to a histone H3. go.json http://purl.obolibrary.org/obo/GO_0140996 GO:0140999 biolink:MolecularActivity histone H3K4 trimethyltransferase activity Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3. EC:2.1.1.354|RHEA:60260 go.json histone H3-K4 trimethylation|histone H3K4 trimethylase activity|histone H3K4 trimethylation|histone lysine N-trimethyltransferase activity (H3-K4 specific) http://purl.obolibrary.org/obo/GO_0140999 GO:0140998 biolink:MolecularActivity histone H2B kinase activity Catalysis of the transfer of a phosphate group to a histone H2B. go.json http://purl.obolibrary.org/obo/GO_0140998 GO:0042439 biolink:BiologicalProcess ethanolamine-containing compound metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. go.json ethanolamine and derivative metabolic process|ethanolamine and derivative metabolism|ethanolamine-containing compound metabolism http://purl.obolibrary.org/obo/GO_0042439 GO:0042438 biolink:BiologicalProcess melanin biosynthetic process The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. go.json melanin anabolism|melanin biosynthesis|melanin formation|melanin synthesis http://purl.obolibrary.org/obo/GO_0042438 GO:0140991 biolink:BiologicalProcess piRNA-mediated gene silencing by mRNA destabilization A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping. go.json http://purl.obolibrary.org/obo/GO_0140991 GO:0042435 biolink:BiologicalProcess indole-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. go.json indole derivative biosynthesis|indole derivative biosynthetic process|indole-containing compound anabolism|indole-containing compound biosynthesis|indole-containing compound formation|indole-containing compound synthesis http://purl.obolibrary.org/obo/GO_0042435 GO:0140990 biolink:BiologicalProcess primary piRNA processing The process involved in converting precursor piRNAs into non-overlapping, contiguous primary piRNAs (approximately 24-30-nt piRNAs with a preference for a 5' uridine (U) via the endonucleolytic activity of cytosolic PIWI. This may include pre-piRNA maturation of 3' ends by trimming and 2'-O-methylation. go.json http://purl.obolibrary.org/obo/GO_0140990 GO:0042434 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042434 GO:0042437 biolink:BiologicalProcess indoleacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants. go.json IAA catabolic process|indole acetic acid catabolic process|indole acetic acid catabolism|indoleacetic acid breakdown|indoleacetic acid catabolism|indoleacetic acid degradation http://purl.obolibrary.org/obo/GO_0042437 GO:0140993 biolink:MolecularActivity histone modifying activity A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression. go.json http://purl.obolibrary.org/obo/GO_0140993 GO:0042436 biolink:BiologicalProcess indole-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. go.json indole derivative catabolic process|indole derivative catabolism|indole-containing compound breakdown|indole-containing compound catabolism|indole-containing compound degradation http://purl.obolibrary.org/obo/GO_0042436 GO:0140948 biolink:MolecularActivity histone H3K9 monomethyltransferase activity Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me. EC:2.1.1.367|RHEA:60288 go.json histone H3-K9 methylation|histone H3K9 methylation|histone H3K9 monomethylase activity|histone lysine N-monomethyltransferase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0140948 GO:0140947 biolink:MolecularActivity histone H3K9me2 methyltransferase activity Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3. EC:2.1.1.366|RHEA:60280 go.json histone H3-K9 trimethylation|histone H3K9 trimethylation|histone H3K9me2 methylase activity|histone dimethyl-lysine(H3K9) N-methyltransferase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0140947 GO:0140949 biolink:MolecularActivity histone H3K9 trimethyltransferase activity Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3. EC:2.1.1.355|RHEA:60276 go.json histone H3-K9 trimethylation|histone H3K9 mono/di/trimethylase activity|histone H3K9 trimethylase activity|histone H3K9 trimethylation|histone lysine N-trimethyltransferase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0140949 GO:0042442 biolink:BiologicalProcess melatonin catabolic process The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine). go.json melatonin breakdown|melatonin catabolism|melatonin degradation http://purl.obolibrary.org/obo/GO_0042442 GO:0140940 biolink:MolecularActivity histone H2A methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue. go.json histone H2A methylase activity|histone H2A methylation http://purl.obolibrary.org/obo/GO_0140940 GO:0042441 biolink:BiologicalProcess eye pigment metabolic process The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. go.json eye pigment metabolism http://purl.obolibrary.org/obo/GO_0042441 GO:0140942 biolink:MolecularActivity histone H3K9 dimethyltransferase activity Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2. EC:2.1.1.368|RHEA:64444 go.json histone H3-K9 dimethylation|histone H3K9 dimethylase activity|histone H3K9 dimethylation|histone H3K9 mono/dimethylase activity|histone lysine N-dimethyltransferase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0140942 GO:0042444 biolink:BiologicalProcess phenylethylamine biosynthetic process The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. go.json phenylethylamine anabolism|phenylethylamine biosynthesis|phenylethylamine formation|phenylethylamine synthesis http://purl.obolibrary.org/obo/GO_0042444 GO:0140941 biolink:MolecularActivity histone H4K20me methyltransferase activity Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2. EC:2.1.1.362|RHEA:60348 go.json histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)|histone H4-K20 dimethylation|histone H4K20 dimethylation|histone H4K20me methylase activity http://purl.obolibrary.org/obo/GO_0140941 GO:0042443 biolink:BiologicalProcess phenylethylamine metabolic process The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. go.json phenylethylamine metabolism http://purl.obolibrary.org/obo/GO_0042443 GO:0140944 biolink:MolecularActivity histone H4K20 monomethyltransferase activity Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me. EC:2.1.1.361|RHEA:60344 go.json histone H4-K20 methylation|histone H4K20 methylase activity|histone H4K20 methylation|histone H4K20 monomethylation|histone lysine N-monomethyltransferase activity (H4-K20 specific) http://purl.obolibrary.org/obo/GO_0140944 GO:0140943 biolink:MolecularActivity histone H4K20 trimethyltransferase activity Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3. EC:2.1.1.372|RHEA:64456 go.json histone H4K20 trimethylase activity|histone H4K20 trimethylation|histone lysine N-trimethyltransferase activity (H4-K20 specific) http://purl.obolibrary.org/obo/GO_0140943 GO:0140946 biolink:MolecularActivity histone H3K4 dimethyltransferase activity Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2. EC:2.1.1.370|RHEA:64448 go.json histone H3-K4 dimethylation|histone H3K4 dimethylase activity|histone H3K4 dimethylation|histone lysine N-dimethyltransferase activity (H3-K4 specific) http://purl.obolibrary.org/obo/GO_0140946 GO:0042440 biolink:BiologicalProcess pigment metabolic process The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. go.json pigment metabolism http://purl.obolibrary.org/obo/GO_0042440 goslim_drosophila|goslim_pir GO:0140945 biolink:MolecularActivity histone H3K4 monomethyltransferase activity Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me. EC:2.1.1.364|RHEA:60264 go.json histone H3K4 monomethylase activity|histone H4-K4 methylation|histone H4K4 methylation|histone lysine N-monomethyltransferase activity (H3-K4 specific) http://purl.obolibrary.org/obo/GO_0140945 GO:0042449 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042449 GO:0042446 biolink:BiologicalProcess hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. go.json hormone anabolism|hormone biosynthesis|hormone formation|hormone synthesis http://purl.obolibrary.org/obo/GO_0042446 GO:0042445 biolink:BiologicalProcess hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. go.json cellular hormone metabolic process|hormone metabolism http://purl.obolibrary.org/obo/GO_0042445 goslim_pir GO:0042448 biolink:BiologicalProcess progesterone metabolic process The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. go.json progesterone metabolism http://purl.obolibrary.org/obo/GO_0042448 GO:0042447 biolink:BiologicalProcess hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. go.json hormone breakdown|hormone catabolism|hormone degradation http://purl.obolibrary.org/obo/GO_0042447 GO:0140937 biolink:MolecularActivity histone H4K12 deacetylase activity Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein. go.json histone H4-K12 deacetylase activity|histone H4-K12 deacetylation|histone H4K12 deacetylation|histone deacetylase activity (H4-K12 specific) http://purl.obolibrary.org/obo/GO_0140937 GO:0140936 biolink:MolecularActivity histone H2B deubiquitinase activity A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated. go.json histone H2B deubiquitination http://purl.obolibrary.org/obo/GO_0140936 GO:0140939 biolink:MolecularActivity histone H4 methyltransferase activity Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. Reactome:R-HSA-5423038|Reactome:R-HSA-5651654|Reactome:R-HSA-5651657 go.json histone H4 methylase activity|histone H4 methylation http://purl.obolibrary.org/obo/GO_0140939 GO:0140938 biolink:MolecularActivity histone H3 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue. Reactome:R-HSA-3788745|Reactome:R-HSA-3788748|Reactome:R-HSA-4827382|Reactome:R-HSA-4827383|Reactome:R-HSA-5159245|Reactome:R-HSA-5205799|Reactome:R-HSA-5244692|Reactome:R-HSA-5634729|Reactome:R-HSA-5634750|Reactome:R-HSA-5634802|Reactome:R-HSA-5637686|Reactome:R-HSA-5638141|Reactome:R-HSA-5638157|Reactome:R-HSA-5638332|Reactome:R-HSA-5638333|Reactome:R-HSA-5649764|Reactome:R-HSA-5649799|Reactome:R-HSA-5649800|Reactome:R-HSA-5649801|Reactome:R-HSA-5649802|Reactome:R-HSA-5661117|Reactome:R-HSA-8936584|Reactome:R-HSA-8936608|Reactome:R-HSA-8937022|Reactome:R-HSA-8937113 go.json histone H3 methylase activity|histone H3 methylation http://purl.obolibrary.org/obo/GO_0140938 GO:0042453 biolink:BiologicalProcess deoxyguanosine metabolic process The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. go.json deoxyguanosine metabolism http://purl.obolibrary.org/obo/GO_0042453 GO:0042452 biolink:BiologicalProcess deoxyguanosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. go.json deoxyguanosine anabolism|deoxyguanosine biosynthesis|deoxyguanosine formation|deoxyguanosine synthesis http://purl.obolibrary.org/obo/GO_0042452 GO:0042455 biolink:BiologicalProcess ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json ribonucleoside anabolism|ribonucleoside biosynthesis|ribonucleoside formation|ribonucleoside synthesis http://purl.obolibrary.org/obo/GO_0042455 GO:0140931 biolink:MolecularActivity neutral L-amino acid:sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in). go.json neutral amino acid:sodium:chloride symporter activity http://purl.obolibrary.org/obo/GO_0140931 GO:0042454 biolink:BiologicalProcess ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json ribonucleoside breakdown|ribonucleoside catabolism|ribonucleoside degradation http://purl.obolibrary.org/obo/GO_0042454 GO:0140930 biolink:MolecularActivity fructose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in). go.json http://purl.obolibrary.org/obo/GO_0140930 GO:0140933 biolink:MolecularActivity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+. EC:3.6.1.62|RHEA:67484 go.json m(7)GpppN-mRNA hydrolase activity http://purl.obolibrary.org/obo/GO_0140933 GO:0140932 biolink:MolecularActivity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate. EC:3.6.1.59 go.json m(7)GpppN m(7)GMP phosphohydrolase activity|m(7)GpppX diphosphatase activity|m(7)GpppX pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0140932 GO:0042451 biolink:BiologicalProcess purine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json purine nucleoside anabolism|purine nucleoside biosynthesis|purine nucleoside formation|purine nucleoside synthesis http://purl.obolibrary.org/obo/GO_0042451 GO:0140935 biolink:MolecularActivity histone H2B conserved C-terminal lysine deubiquitinase activity A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals. go.json histone conserved C-terminal lysine deubiquitination http://purl.obolibrary.org/obo/GO_0140935 GO:0042450 biolink:BiologicalProcess arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. go.json arginine anabolism via ornithine|arginine formation via ornithine|arginine synthesis via ornithine http://purl.obolibrary.org/obo/GO_0042450 GO:0140934 biolink:MolecularActivity histone deubiquitinase activity A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated. go.json histone deubiquitination http://purl.obolibrary.org/obo/GO_0140934 GO:0042457 biolink:BiologicalProcess ethylene catabolic process The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. go.json ethene catabolic process|ethene catabolism|ethylene breakdown|ethylene catabolism|ethylene degradation http://purl.obolibrary.org/obo/GO_0042457 GO:0042456 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042456 GO:0042459 biolink:BiologicalProcess octopine catabolic process to proline The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline. MetaCyc:OCTOPINEDEG-PWY go.json octopine breakdown to proline|octopine degradation to proline http://purl.obolibrary.org/obo/GO_0042459 GO:0042458 biolink:BiologicalProcess nopaline catabolic process to proline The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline. MetaCyc:NOPALINEDEG-PWY go.json nopaline breakdown to proline|nopaline degradation to proline http://purl.obolibrary.org/obo/GO_0042458 GO:0140969 biolink:BiologicalProcess determination of lung left/right asymmetry Determination of the asymmetric location of the lungs with respect to the left and right halves of the organism. go.json http://purl.obolibrary.org/obo/GO_0140969 GO:0140962 biolink:BiologicalProcess multicellular organismal-level chemical homeostasis A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. go.json multicellular organism level chemical homeostasis|organismal level chemical homeostasis http://purl.obolibrary.org/obo/GO_0140962 GO:0042464 biolink:BiologicalProcess dosage compensation by hypoactivation of X chromosome Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans. Wikipedia:XY_sex-determination_system go.json http://purl.obolibrary.org/obo/GO_0042464 GO:0042463 biolink:BiologicalProcess ocellus photoreceptor cell development Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus. go.json non-eye photoreceptor development http://purl.obolibrary.org/obo/GO_0042463 GO:0140961 biolink:BiologicalProcess cellular detoxification of metal ion Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion. go.json cellular detoxification of metal cation http://purl.obolibrary.org/obo/GO_0140961 GO:0140964 biolink:BiologicalProcess intracellular auxin homeostasis A homeostatic process involved in the maintenance of a steady state level of auxin within a cell. go.json auxin homeostasis|cellular auxin homeostasis http://purl.obolibrary.org/obo/GO_0140964 GO:0042466 biolink:BiologicalProcess chemokinesis A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis). Wikipedia:Chemokinesis go.json http://purl.obolibrary.org/obo/GO_0042466 GO:0140963 biolink:BiologicalProcess obsolete multicellular organismal-level auxin homeostasis OBSOLETE. A chemical homeostatic process involved in the maintenance of a steady state level of auxin within extracellular body fluids, such as the xylem or phloem of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. go.json auxin homeostasis|multicellular organismal auxin homeostasis True http://purl.obolibrary.org/obo/GO_0140963 GO:0042465 biolink:BiologicalProcess kinesis The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus. Wikipedia:Kinesis go.json http://purl.obolibrary.org/obo/GO_0042465 GO:0140966 biolink:BiologicalProcess piRNA-mediated heterochromatin formation The formation of heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering piRNA. go.json piRNA-directed heterochromatin formation|piwiRNA-directed heterochromatin formation http://purl.obolibrary.org/obo/GO_0140966 GO:0042460 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042460 GO:0140965 biolink:BiologicalProcess secondary piRNA processing A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi proteins aubergine and Argonaute 3 and in mice, the piwi proteins Piwil2 and Piwil4. go.json ping-pong amplification|ping-pong derived piRNA|secondary PIWI-associated RNA processing|secondary piRNA biogenesis http://purl.obolibrary.org/obo/GO_0140965 GO:0042462 biolink:BiologicalProcess eye photoreceptor cell development Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. go.json http://purl.obolibrary.org/obo/GO_0042462 GO:0140968 biolink:MolecularActivity polyspecific organic cation:proton antiporter activity Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics. TC:2.A.66.1.20 go.json proton:polyspecific organic cation antiporter activity http://purl.obolibrary.org/obo/GO_0140968 GO:0042461 biolink:BiologicalProcess photoreceptor cell development Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. go.json photoreceptor morphogenesis http://purl.obolibrary.org/obo/GO_0042461 GO:0140967 biolink:BiologicalProcess manganese import into cell The directed movement of mangnanese ions from outside of a cell into a cell. go.json manganese influx http://purl.obolibrary.org/obo/GO_0140967 GO:0042468 biolink:BiologicalProcess klinokinesis The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered. go.json http://purl.obolibrary.org/obo/GO_0042468 GO:0042467 biolink:BiologicalProcess orthokinesis The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased. go.json http://purl.obolibrary.org/obo/GO_0042467 GO:0042469 biolink:MolecularActivity versicolorin reductase activity Catalysis of the reduction of versicolorin A to sterigmatocystin. go.json http://purl.obolibrary.org/obo/GO_0042469 GO:0140959 biolink:MolecularActivity obsolete base-pairing target-directed miRNA suppressor activity OBSOLETE. An inhibitor activity that acts by base-pairing with a miRNA, exposing it to nuclease-mediated degradation. go.json base-pairing target-directed microRNA suppressor activity True http://purl.obolibrary.org/obo/GO_0140959 GO:0140958 biolink:BiologicalProcess target-directed miRNA degradation The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases. go.json TDMD|target-directed microRNA degradation http://purl.obolibrary.org/obo/GO_0140958 GO:0140951 biolink:MolecularActivity histone H3K27 trimethyltransferase activity Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3. EC:2.1.1.356|RHEA:60292 go.json histone H3-K27 trimethylase activity|histone H3-K27 trimethylation|histone H3K27 mono/di/trimethylase activity|histone H3K27 trimethylase activity|histone H3K27 trimethylation|histone lysine N-trimethyltransferase activity (H3-K27 specific) http://purl.obolibrary.org/obo/GO_0140951 GO:0042475 biolink:BiologicalProcess odontogenesis of dentin-containing tooth The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. go.json odontogenesis of dentine-containing teeth|odontogenesis of dentine-containing tooth|odontogeny|odontosis|tooth development http://purl.obolibrary.org/obo/GO_0042475 GO:0140950 biolink:MolecularActivity histone H2A deubiquitinase activity A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated. go.json histone H2A deubiquitination http://purl.obolibrary.org/obo/GO_0140950 GO:0042474 biolink:BiologicalProcess middle ear morphogenesis The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). go.json http://purl.obolibrary.org/obo/GO_0042474 GO:0140953 biolink:MolecularActivity histone H3K27 monomethyltransferase activity Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me. EC:2.1.1.369|RHEA:60296 go.json histone H3-K27 methylation|histone H3-K27 monomethylase activity|histone H3K27 methylation|histone H3K27 monomethylase activity|histone lysine N-monomethyltransferase activity (H3-K27 specific) http://purl.obolibrary.org/obo/GO_0140953 GO:0042477 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042477 GO:0042476 biolink:BiologicalProcess odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. Wikipedia:Odontogenesis go.json odontogenesis of calcareous or chitinous tooth|odontogeny|odontosis|tooth development|tooth morphogenesis http://purl.obolibrary.org/obo/GO_0042476 GO:0140952 biolink:MolecularActivity histone H3K27 dimethyltransferase activity Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2. EC:2.1.1.371|RHEA:64452 go.json histone H3-K27 dimethylase activity|histone H3-K27 dimethylation|histone H3K27 dimethylase activity|histone H3K27 dimethylation|histone H3K27 mono/dimethylase activity|histone lysine N-dimethyltransferase activity (H3-K27 specific) http://purl.obolibrary.org/obo/GO_0140952 GO:0140955 biolink:MolecularActivity histone H3K36 trimethyltransferase activity Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3. EC:2.1.1.359|RHEA:60324 go.json histone H3-K36 trimethylation|histone H3K36 mono/di/trimethylase activity|histone H3K36 trimethylase activity|histone H3K36 trimethylation|histone lysine N-trimethyltransferase activity (H3-K36 specific) http://purl.obolibrary.org/obo/GO_0140955 GO:0042471 biolink:BiologicalProcess ear morphogenesis The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. go.json hearing organ morphogenesis http://purl.obolibrary.org/obo/GO_0042471 GO:0140954 biolink:MolecularActivity histone H3K36 dimethyltransferase activity Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2. EC:2.1.1.357|RHEA:60308 go.json histone H3-K36 dimethylation|histone H3K36 dimethylase activity|histone H3K36 dimethylation|histone H3K36 mono/dimethylase activity|histone lysine N-dimethyltransferase activity (H3-K36 specific) http://purl.obolibrary.org/obo/GO_0140954 GO:0042470 biolink:CellularComponent melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. Wikipedia:Melanosome go.json http://purl.obolibrary.org/obo/GO_0042470 GO:0042473 biolink:BiologicalProcess outer ear morphogenesis The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull. go.json http://purl.obolibrary.org/obo/GO_0042473 GO:0140956 biolink:MolecularActivity histone H3K79 trimethyltransferase activity Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3. EC:2.1.1.360|RHEA:60328 go.json histone H3-K79 trimethylation|histone H3K79 trimethylase activity|histone H3K79 trimethylation|histone lysine N-trimethyltransferase activity (H3-K79 specific)|histone trimethylase activity (H3-K79 specific)|histone trimethyltransferase activity (H3-K79 specific)|histone-H3K79 trimethyltransferase activity http://purl.obolibrary.org/obo/GO_0140956 GO:0042472 biolink:BiologicalProcess inner ear morphogenesis The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. go.json http://purl.obolibrary.org/obo/GO_0042472 GO:0042479 biolink:BiologicalProcess positive regulation of eye photoreceptor cell development Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. go.json activation of eye photoreceptor cell development|positive regulation of eye photoreceptor development|stimulation of eye photoreceptor cell development|up regulation of eye photoreceptor cell development|up-regulation of eye photoreceptor cell development|upregulation of eye photoreceptor cell development http://purl.obolibrary.org/obo/GO_0042479 GO:0042478 biolink:BiologicalProcess regulation of eye photoreceptor cell development Any process that modulates the frequency, rate or extent of eye photoreceptor development. go.json regulation of eye photoreceptor development http://purl.obolibrary.org/obo/GO_0042478 GO:0140805 biolink:MolecularActivity NAD+-protein-serine ADP-ribosyltransferase activity Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. RHEA:58232 go.json http://purl.obolibrary.org/obo/GO_0140805 GO:0140804 biolink:MolecularActivity NAD+- protein-lysine ADP-ribosyltransferase activity Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide. RHEA:58220 go.json http://purl.obolibrary.org/obo/GO_0140804 GO:0140807 biolink:MolecularActivity NAD+-protein-glutamate ADP-ribosyltransferase activity Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide. go.json http://purl.obolibrary.org/obo/GO_0140807 GO:0140806 biolink:MolecularActivity NAD+- protein-aspartate ADP-ribosyltransferase activity Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. go.json http://purl.obolibrary.org/obo/GO_0140806 GO:0140809 biolink:MolecularActivity histone H4R3 arginine deiminase activity Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3. go.json H4-R3 citrullination|histone H4-R3 arginine deiminase activity|histone-arginine deiminase activity (H4-R3 specific) http://purl.obolibrary.org/obo/GO_0140809 GO:0140808 biolink:MolecularActivity NAD+-protein-tyrosine ADP-ribosyltransferase activity Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]. RHEA:58236 go.json http://purl.obolibrary.org/obo/GO_0140808 GO:0140801 biolink:MolecularActivity histone H2AXY142 kinase activity Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX. go.json gamma-H2AX-S142 kinase activity|histone H2AX-Y142 kinase activity|histone H2AY142 kinase activity|histone kinase activity (H2AX-Y142 specific) http://purl.obolibrary.org/obo/GO_0140801 GO:0140800 biolink:MolecularActivity gamma-aminobutyric acid:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out). go.json http://purl.obolibrary.org/obo/GO_0140800 GO:0140803 biolink:MolecularActivity NAD+- protein-cysteine ADP-ribosyltransferase activity Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. RHEA:56612 go.json http://purl.obolibrary.org/obo/GO_0140803 GO:0140802 biolink:MolecularActivity NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide. RHEA:58268 go.json http://purl.obolibrary.org/obo/GO_0140802 GO:0140863 biolink:MolecularActivity histone H2AK127 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue. go.json histone H2A-K127 ubiquitin ligase activity|histone ubiquitin ligase activity (H2A-K127 specific) http://purl.obolibrary.org/obo/GO_0140863 GO:0140862 biolink:MolecularActivity histone H2AK119 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue. go.json histone H2A-K119 ubiquitin ligase activity|histone ubiquitin ligase activity (H2A-K119 specific) http://purl.obolibrary.org/obo/GO_0140862 GO:0140865 biolink:BiologicalProcess interleukin-22-mediated signaling pathway The series of molecular signals initiated by interleukin-22 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-22-mediated signaling pathway|interleukin-22-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140865 GO:0042521 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042521 GO:0140864 biolink:MolecularActivity histone H2AK129 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue. go.json histone H2A-K129 ubiquitin ligase activity|histone ubiquitin ligase activity (H2A-K129 specific) http://purl.obolibrary.org/obo/GO_0140864 GO:0042520 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042520 GO:0140867 biolink:MolecularActivity NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue). go.json NAD+-histone H2B-E18 glutamate ADP-ribosyltransferase activity|NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E18 specific) http://purl.obolibrary.org/obo/GO_0140867 GO:0140866 biolink:BiologicalProcess interleukin-20-mediated signaling pathway The series of molecular signals initiated by interleukin-20 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-20-mediated signaling pathway|interleukin-20-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140866 GO:0140869 biolink:MolecularActivity miRNA inhibitor activity via base-pairing Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs). go.json base-pairing target-directed miRNA suppressor activity|base-pairing target-directed microRNA suppressor activity|miRNA base-pairing repressor activity|miRNA binding involved in posttranscriptional gene silencing|miRNA inhibitor activity|miRNA sponge http://purl.obolibrary.org/obo/GO_0140869 GO:0140868 biolink:MolecularActivity 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming) Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product. EC:1.3.8.2|RHEA:42800 go.json 4,4'-diapophytoene desaturase activity http://purl.obolibrary.org/obo/GO_0140868 GO:0042527 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042527 GO:0042526 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042526 GO:0042529 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042529 GO:0042528 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042528 GO:0042523 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042523 GO:0042522 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042522 GO:0042525 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042525 GO:0140861 biolink:BiologicalProcess DNA repair-dependent chromatin remodeling A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions. go.json DNA damage-dependent chromatin remodelling http://purl.obolibrary.org/obo/GO_0140861 GO:0140860 biolink:MolecularActivity (3R)-2'-hydroxyisoflavanone reductase activity Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH. go.json vestitone reductase activity http://purl.obolibrary.org/obo/GO_0140860 GO:0042524 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042524 GO:0140859 biolink:MolecularActivity pterocarpan synthase activity Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol. EC:4.2.1.139|RHEA:35407 go.json 2',7-dihydroxy-4'-methoxyisoflavanol dehydratase activity|2'-hydroxyisoflavanol 4,2'-dehydratase activity|7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase activity|medicarpan synthase activity|medicarpin synthase activity http://purl.obolibrary.org/obo/GO_0140859 GO:0140852 biolink:MolecularActivity histone ubiquitin ligase activity Catalysis of the transfer of ubiquitin to a histone substrate. go.json http://purl.obolibrary.org/obo/GO_0140852 GO:0150200 biolink:BiologicalProcess regulation of transport across blood-brain barrier Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier. go.json http://purl.obolibrary.org/obo/GO_0150200 GO:0042530 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042530 GO:0140851 biolink:MolecularActivity histone H3K14 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue. go.json histone H3-K14 ubiquitin ligase activity|histone ubiquitin ligase activity (H3-K14 specific) http://purl.obolibrary.org/obo/GO_0140851 GO:0042532 biolink:BiologicalProcess negative regulation of tyrosine phosphorylation of STAT protein Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json down regulation of tyrosine phosphorylation of STAT protein|down regulation of tyrosine phosphorylation of Stat1 protein|down regulation of tyrosine phosphorylation of Stat2 protein|down regulation of tyrosine phosphorylation of Stat3 protein|down regulation of tyrosine phosphorylation of Stat4 protein|down regulation of tyrosine phosphorylation of Stat5 protein|down regulation of tyrosine phosphorylation of Stat6 protein|down regulation of tyrosine phosphorylation of Stat7 protein|down-regulation of tyrosine phosphorylation of STAT protein|down-regulation of tyrosine phosphorylation of Stat1 protein|down-regulation of tyrosine phosphorylation of Stat2 protein|down-regulation of tyrosine phosphorylation of Stat3 protein|down-regulation of tyrosine phosphorylation of Stat4 protein|down-regulation of tyrosine phosphorylation of Stat5 protein|down-regulation of tyrosine phosphorylation of Stat6 protein|down-regulation of tyrosine phosphorylation of Stat7 protein|downregulation of tyrosine phosphorylation of STAT protein|downregulation of tyrosine phosphorylation of Stat1 protein|downregulation of tyrosine phosphorylation of Stat2 protein|downregulation of tyrosine phosphorylation of Stat3 protein|downregulation of tyrosine phosphorylation of Stat4 protein|downregulation of tyrosine phosphorylation of Stat5 protein|downregulation of tyrosine phosphorylation of Stat6 protein|downregulation of tyrosine phosphorylation of Stat7 protein|inhibition of tyrosine phosphorylation of STAT protein|inhibition of tyrosine phosphorylation of Stat1 protein|inhibition of tyrosine phosphorylation of Stat2 protein|inhibition of tyrosine phosphorylation of Stat3 protein|inhibition of tyrosine phosphorylation of Stat4 protein|inhibition of tyrosine phosphorylation of Stat5 protein|inhibition of tyrosine phosphorylation of Stat6 protein|inhibition of tyrosine phosphorylation of Stat7 protein|negative regulation of tyrosine phosphorylation of Stat1 protein|negative regulation of tyrosine phosphorylation of Stat2 protein|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat4 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|negative regulation of tyrosine phosphorylation of Stat6 protein|negative regulation of tyrosine phosphorylation of Stat7 protein http://purl.obolibrary.org/obo/GO_0042532 GO:0140854 biolink:BiologicalProcess interleukin-19-mediated signaling pathway The series of molecular signals initiated by interleukin-19 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL19-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140854 GO:0140853 biolink:MolecularActivity cholesterol-protein transferase activity Catalysis of the transfer of a cholesterol to an acceptor protein. go.json cholesterol transferase activity http://purl.obolibrary.org/obo/GO_0140853 GO:0042531 biolink:BiologicalProcess positive regulation of tyrosine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json activation of tyrosine phosphorylation of STAT protein|activation of tyrosine phosphorylation of Stat1 protein|activation of tyrosine phosphorylation of Stat2 protein|activation of tyrosine phosphorylation of Stat3 protein|activation of tyrosine phosphorylation of Stat4 protein|activation of tyrosine phosphorylation of Stat5 protein|activation of tyrosine phosphorylation of Stat6 protein|activation of tyrosine phosphorylation of Stat7 protein|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat2 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of tyrosine phosphorylation of Stat6 protein|positive regulation of tyrosine phosphorylation of Stat7 protein|stimulation of tyrosine phosphorylation of STAT protein|stimulation of tyrosine phosphorylation of Stat1 protein|stimulation of tyrosine phosphorylation of Stat2 protein|stimulation of tyrosine phosphorylation of Stat3 protein|stimulation of tyrosine phosphorylation of Stat4 protein|stimulation of tyrosine phosphorylation of Stat5 protein|stimulation of tyrosine phosphorylation of Stat6 protein|stimulation of tyrosine phosphorylation of Stat7 protein|up regulation of tyrosine phosphorylation of STAT protein|up regulation of tyrosine phosphorylation of Stat1 protein|up regulation of tyrosine phosphorylation of Stat2 protein|up regulation of tyrosine phosphorylation of Stat3 protein|up regulation of tyrosine phosphorylation of Stat4 protein|up regulation of tyrosine phosphorylation of Stat5 protein|up regulation of tyrosine phosphorylation of Stat6 protein|up regulation of tyrosine phosphorylation of Stat7 protein|up-regulation of tyrosine phosphorylation of STAT protein|up-regulation of tyrosine phosphorylation of Stat1 protein|up-regulation of tyrosine phosphorylation of Stat2 protein|up-regulation of tyrosine phosphorylation of Stat3 protein|up-regulation of tyrosine phosphorylation of Stat4 protein|up-regulation of tyrosine phosphorylation of Stat5 protein|up-regulation of tyrosine phosphorylation of Stat6 protein|up-regulation of tyrosine phosphorylation of Stat7 protein|upregulation of tyrosine phosphorylation of STAT protein|upregulation of tyrosine phosphorylation of Stat1 protein|upregulation of tyrosine phosphorylation of Stat2 protein|upregulation of tyrosine phosphorylation of Stat3 protein|upregulation of tyrosine phosphorylation of Stat4 protein|upregulation of tyrosine phosphorylation of Stat5 protein|upregulation of tyrosine phosphorylation of Stat6 protein|upregulation of tyrosine phosphorylation of Stat7 protein http://purl.obolibrary.org/obo/GO_0042531 GO:0140856 biolink:MolecularActivity histone H2AK13 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue. go.json histone ubiquitin ligase activity (H2A-K13 specific) http://purl.obolibrary.org/obo/GO_0140856 GO:0140855 biolink:MolecularActivity histone H3S57 kinase activity Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3. go.json histone kinase activity (H3-S57 specific)|histone serine kinase activity (H3-S57 specific)|histone-serine kinase activity (H3-S57 specific) http://purl.obolibrary.org/obo/GO_0140855 GO:0140858 biolink:MolecularActivity histone H2AK15 ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue. go.json histone ubiquitin ligase activity (H2A-K15 specific) http://purl.obolibrary.org/obo/GO_0140858 GO:0140857 biolink:MolecularActivity histone H3T45 kinase activity Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3. go.json histone kinase activity (H3-T45 specific)|histone threonine kinase activity (H3-T45 specific)|histone-threonine kinase activity (H3-T45 specific) http://purl.obolibrary.org/obo/GO_0140857 GO:0042538 biolink:BiologicalProcess hyperosmotic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json response to hyperosmotic salt stress|salt tolerance http://purl.obolibrary.org/obo/GO_0042538 GO:0042537 biolink:BiologicalProcess benzene-containing compound metabolic process The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. go.json benzene and derivative metabolic process|benzene and derivative metabolism|benzene-containing compound metabolism http://purl.obolibrary.org/obo/GO_0042537 GO:0042539 biolink:BiologicalProcess hypotonic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json response to hypotonic salt stress http://purl.obolibrary.org/obo/GO_0042539 GO:0042534 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042534 GO:0042533 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042533 GO:0150202 biolink:BiologicalProcess negative regulation of transport across blood-brain barrier Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier. go.json http://purl.obolibrary.org/obo/GO_0150202 GO:0140850 biolink:MolecularActivity histone H2B C-terminal K residue ubiquitin ligase activity Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals. go.json histone H2B conserved C-terminal lysine ubiquitin ligase activity|histone H2B-K120 ubiquitin ligase activity|histone H2BK120 ubiquitin ligase activity|histone ubiquitin ligase activity (H2B-K120 specific) http://purl.obolibrary.org/obo/GO_0140850 GO:0042536 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042536 GO:0150201 biolink:BiologicalProcess positive regulation of transport across blood-brain barrier Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier. go.json http://purl.obolibrary.org/obo/GO_0150201 GO:0042535 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042535 GO:0140885 biolink:BiologicalProcess suppression by virus of host type III interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda. go.json negative regulation by virus of host type III interferon-mediated signaling pathway|suppression by virus of host type III IFN-mediated signaling pathway|suppression by virus of host type III interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140885 GO:0042541 biolink:BiologicalProcess hemoglobin biosynthetic process The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. go.json haemoglobin biosynthesis|haemoglobin biosynthetic process|hemoglobin anabolism|hemoglobin biosynthesis|hemoglobin formation|hemoglobin synthesis http://purl.obolibrary.org/obo/GO_0042541 GO:0140884 biolink:BiologicalProcess suppression by virus of host type II interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma. go.json negative regulation by virus of host type II interferon-mediated signaling pathway|suppression by virus of host type II IFN-mediated signaling pathway|suppression by virus of host type II interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140884 GO:0042540 biolink:BiologicalProcess hemoglobin catabolic process The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids. go.json haemoglobin catabolic process|haemoglobin catabolism|haemoglobin hydrolysis|hemoglobin breakdown|hemoglobin catabolism|hemoglobin degradation|hemoglobin hydrolysis http://purl.obolibrary.org/obo/GO_0042540 GO:0042543 biolink:BiologicalProcess protein N-linked glycosylation via arginine The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine. RESID:AA0327 go.json protein amino acid N-linked glycosylation via arginine http://purl.obolibrary.org/obo/GO_0042543 GO:0140887 biolink:BiologicalProcess positive regulation of nucleosome disassembly Any process that activates or increases the frequency, rate or extent of the controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. go.json http://purl.obolibrary.org/obo/GO_0140887 GO:0140886 biolink:BiologicalProcess suppression by virus of host interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism. go.json inhibition of host interferon signaling pathway by virus|negative regulation by virus of host interferon-mediated signaling pathway|suppression by virus of host IFN-mediated signaling pathway|suppression by virus of host interferon-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140886 GO:0042542 biolink:BiologicalProcess response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0042542 GO:0140889 biolink:BiologicalProcess DNA replication-dependent chromatin disassembly The disruption of nucleosomes during DNA replication to allow the replication machinery to access the DNA. go.json http://purl.obolibrary.org/obo/GO_0140889 GO:0140888 biolink:BiologicalProcess interferon-mediated signaling pathway The series of molecular signals initiated by type II interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type II interferon is also known as interferon-gamma. go.json interferon signaling pathway|interferon-activated signaling pathway http://purl.obolibrary.org/obo/GO_0140888 GO:0042549 biolink:BiologicalProcess photosystem II stabilization The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0042549 GO:0042548 biolink:BiologicalProcess regulation of photosynthesis, light reaction Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0042548 GO:0140881 biolink:BiologicalProcess positive regulation terrein biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of the fungal metabolite terrein. go.json http://purl.obolibrary.org/obo/GO_0140881 GO:0042545 biolink:BiologicalProcess cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. go.json http://purl.obolibrary.org/obo/GO_0042545 GO:0042544 biolink:BiologicalProcess melibiose biosynthetic process The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. go.json melibiose anabolism|melibiose biosynthesis|melibiose formation|melibiose synthesis http://purl.obolibrary.org/obo/GO_0042544 GO:0140880 biolink:BiologicalProcess terrein biosynthetic process The chemical reactions and pathways resulting in the formation of terrein, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities. go.json terrein anabolism|terrein biosynthesis|terrein formation|terrein synthesis http://purl.obolibrary.org/obo/GO_0140880 GO:0140883 biolink:BiologicalProcess induction by virus of host reticulophagy Any process in which a virus activates or increases the frequency, rate or extent of reticulophagy in the host. go.json activation of host reticulophagy by virus|positive regulation by virus of host reticulophagy http://purl.obolibrary.org/obo/GO_0140883 GO:0042547 biolink:BiologicalProcess cell wall modification involved in multidimensional cell growth The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth. go.json cell wall modification during cell expansion|cell wall modification during multidimensional cell growth http://purl.obolibrary.org/obo/GO_0042547 GO:0042546 biolink:BiologicalProcess cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. go.json cell wall assembly http://purl.obolibrary.org/obo/GO_0042546 GO:0140882 biolink:BiologicalProcess zinc export across plasma membrane The directed movement of zinc ions from a cell, into the extracellular region. go.json zinc ion export from cell http://purl.obolibrary.org/obo/GO_0140882 GO:0140874 biolink:BiologicalProcess paraherquonin biosynthetic process The chemical reactions and pathways resulting in the formation of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture. go.json paraherquonin anabolism|paraherquonin biosynthesis|paraherquonin formation|paraherquonin synthesis http://purl.obolibrary.org/obo/GO_0140874 GO:0042552 biolink:BiologicalProcess myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. Wikipedia:Myelin go.json myelinogenesis http://purl.obolibrary.org/obo/GO_0042552 GO:0140873 biolink:BiologicalProcess paxilline biosynthetic process The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. MetaCyc:PWY-7493 go.json paxilline anabolism|paxilline biosynthesis|paxilline formation|paxilline synthesis http://purl.obolibrary.org/obo/GO_0140873 GO:0042551 biolink:BiologicalProcess neuron maturation A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0042551 GO:0042554 biolink:BiologicalProcess superoxide anion generation The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. go.json superoxide release http://purl.obolibrary.org/obo/GO_0042554 GO:0140876 biolink:BiologicalProcess andrastin A biosynthetic process The chemical reactions and pathways resulting in the formation of andrastin A, a meroterpenoid that exhibits inhibitory activity against ras farnesyltransferase, suggesting that it could have promising antitumor activity. go.json andrastin A anabolism|andrastin A biosynthesis|andrastin A formation|andrastin A synthesis http://purl.obolibrary.org/obo/GO_0140876 GO:0140875 biolink:BiologicalProcess PR-toxin biosynthetic process The chemical reactions and pathways resulting in the formation of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin. go.json PR-toxin anabolism|PR-toxin biosynthesis|PR-toxin formation|PR-toxin synthesis http://purl.obolibrary.org/obo/GO_0140875 GO:0042553 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042553 GO:0140878 biolink:BiologicalProcess griseofulvin biosynthetic process The chemical reactions and pathways resulting in the formation of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. MetaCyc:PWY-7653 go.json griseofulvin anabolism|griseofulvin biosynthesis|griseofulvin formation|griseofulvin synthesis http://purl.obolibrary.org/obo/GO_0140878 GO:0140877 biolink:BiologicalProcess mevastatin biosynthetic process The chemical reactions and pathways resulting in the formation of mevastatin , also known as compactin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase. go.json mevastatin anabolism|mevastatin biosynthesis|mevastatin formation|mevastatin synthesis http://purl.obolibrary.org/obo/GO_0140877 GO:0042550 biolink:BiologicalProcess photosystem I stabilization The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. go.json http://purl.obolibrary.org/obo/GO_0042550 GO:0140879 biolink:BiologicalProcess conidiogenone biosynthetic process The chemical reactions and pathways resulting in the formation of conidiogenone , a diterpene known to induce the conidiation. go.json conidiogenone anabolism|conidiogenone biosynthesis|conidiogenone formation|conidiogenone synthesis http://purl.obolibrary.org/obo/GO_0140879 GO:0042559 biolink:BiologicalProcess pteridine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. go.json pteridine and derivative biosynthesis|pteridine and derivative biosynthetic process|pteridine-containing compound anabolism|pteridine-containing compound biosynthesis|pteridine-containing compound formation|pteridine-containing compound synthesis|pterin biosynthesis|pterin biosynthetic process http://purl.obolibrary.org/obo/GO_0042559 goslim_pombe GO:0140870 biolink:MolecularActivity RNA polymerase inhibitor activity Binds to and stops, prevents or reduces the activity of RNA polymerase. go.json http://purl.obolibrary.org/obo/GO_0140870 GO:0042556 biolink:MolecularActivity eukaryotic elongation factor-2 kinase regulator activity Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase. go.json eEF-2 kinase regulator http://purl.obolibrary.org/obo/GO_0042556 GO:0042555 biolink:CellularComponent MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication. go.json mini-chromosome maintenance complex http://purl.obolibrary.org/obo/GO_0042555 GO:0140872 biolink:BiologicalProcess viridicatumtoxin biosynthetic process The chemical reactions and pathways resulting in the formation of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. MetaCyc:PWY-7659 go.json viridicatumtoxin anabolism|viridicatumtoxin biosynthesis|viridicatumtoxin formation|viridicatumtoxin synthesis http://purl.obolibrary.org/obo/GO_0140872 GO:0042558 biolink:BiologicalProcess pteridine-containing compound metabolic process The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. go.json pteridine and derivative metabolic process|pteridine and derivative metabolism|pteridine-containing compound metabolism|pterin metabolic process|pterin metabolism http://purl.obolibrary.org/obo/GO_0042558 GO:0140871 biolink:MolecularActivity repressor of RNA polymerase inhibitor activity Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor. go.json http://purl.obolibrary.org/obo/GO_0140871 GO:0042557 biolink:MolecularActivity eukaryotic elongation factor-2 kinase activator activity Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase. go.json eEF-2 kinase activator http://purl.obolibrary.org/obo/GO_0042557 GO:0140827 biolink:MolecularActivity zinc chaperone activity Binding to and delivering zinc ions to a target protein. go.json http://purl.obolibrary.org/obo/GO_0140827 GO:0140826 biolink:MolecularActivity zinc:proton antiporter activity Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out). go.json http://purl.obolibrary.org/obo/GO_0140826 GO:0140829 biolink:MolecularActivity bicarbonate:monoatomic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in). TC:2.A.31.1.1 go.json bicarbonate:anion antiporter activity http://purl.obolibrary.org/obo/GO_0140829 GO:0140828 biolink:MolecularActivity metal cation:monoatomic cation antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out). go.json solute:metal cation antiporter activity http://purl.obolibrary.org/obo/GO_0140828 GO:0042563 biolink:CellularComponent obsolete importin alpha-subunit nuclear export complex OBSOLETE. A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to transport the importin alpha-subunit out of the nucleus through the nuclear pore. go.json True http://purl.obolibrary.org/obo/GO_0042563 GO:0042562 biolink:MolecularActivity hormone binding Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. go.json http://purl.obolibrary.org/obo/GO_0042562 goslim_chembl|goslim_pir GO:0140821 biolink:BiologicalProcess UDP-beta-L-arabinofuranose import into Golgi lumen The directed movement of UDP-beta-L-arabinofuranose from the cytosol to the Golgi apparatus of a cell. go.json cytosol to Golgi apparatus UDP-beta-L-arabinofuranose transport http://purl.obolibrary.org/obo/GO_0140821 GO:0042565 biolink:CellularComponent RNA nuclear export complex A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore. go.json http://purl.obolibrary.org/obo/GO_0042565 GO:0140820 biolink:BiologicalProcess cytosol to Golgi apparatus transport The directed movement of substances from the cytosol into the Golgi apparatus of a cell. go.json http://purl.obolibrary.org/obo/GO_0140820 GO:0042564 biolink:CellularComponent NLS-dependent protein nuclear import complex A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore. go.json http://purl.obolibrary.org/obo/GO_0042564 GO:0140823 biolink:MolecularActivity histone H2BS36 kinase activity Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B. go.json histone H2B-S36 kinase activity|histone kinase activity (H2B-S36 specific) http://purl.obolibrary.org/obo/GO_0140823 GO:0140822 biolink:MolecularActivity NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue). go.json NAD+-histone H2B-E35 glutamate ADP-ribosyltransferase activity|NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E35 specific) http://purl.obolibrary.org/obo/GO_0140822 GO:0140825 biolink:MolecularActivity lactoperoxidase activity Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O. EC:1.11.1.7|MetaCyc:PEROXID-RXN|RHEA:56136 go.json peroxidase activity http://purl.obolibrary.org/obo/GO_0140825 GO:0042561 biolink:MolecularActivity alpha-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin. MetaCyc:RXN-8434 go.json http://purl.obolibrary.org/obo/GO_0042561 GO:0042560 biolink:BiologicalProcess pteridine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. go.json pteridine and derivative catabolic process|pteridine and derivative catabolism|pteridine-containing compound breakdown|pteridine-containing compound catabolism|pteridine-containing compound degradation|pterin catabolic process|pterin catabolism http://purl.obolibrary.org/obo/GO_0042560 GO:0140824 biolink:MolecularActivity thioredoxin-dependent peroxiredoxin activity Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. EC:1.11.1.24|RHEA:62620 go.json http://purl.obolibrary.org/obo/GO_0140824 GO:0042567 biolink:CellularComponent insulin-like growth factor ternary complex A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. go.json IGF ternary complex http://purl.obolibrary.org/obo/GO_0042567 GO:0042566 biolink:CellularComponent hydrogenosome A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation. Wikipedia:Hydrogenosome go.json http://purl.obolibrary.org/obo/GO_0042566 goslim_pir GO:0042569 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042569 GO:0042568 biolink:CellularComponent insulin-like growth factor binary complex A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development. go.json IGF binary complex http://purl.obolibrary.org/obo/GO_0042568 GO:0140816 biolink:MolecularActivity NAD+-histone H2BS6 serine ADP-ribosyltransferase activity Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B. go.json NAD+-histone H2B-S6 serine ADP-ribosyltransferase activity|NAD+-histone-serine ADP-ribosyltransferase activity (H2B-S6 specific) http://purl.obolibrary.org/obo/GO_0140816 GO:0140815 biolink:MolecularActivity NAD+-protein-histidine ADP-ribosyltransferase activity Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide. RHEA:72071 go.json http://purl.obolibrary.org/obo/GO_0140815 GO:0140818 biolink:MolecularActivity mRNA 5'-phosphatase activity A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate. EC:3.6.1.74|MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN|RHEA:67004 go.json mRNA 5'-triphosphate monophosphatase activity http://purl.obolibrary.org/obo/GO_0140818 GO:0140817 biolink:MolecularActivity NAD+-histone H3S10 serine ADP-ribosyltransferase activity Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3. go.json NAD+-histone H3-S10 serine ADP-ribosyltransferase activity|NAD+-histone-serine ADP-ribosyltransferase activity (H3-S10 specific) http://purl.obolibrary.org/obo/GO_0140817 GO:0140819 biolink:MolecularActivity UDP-beta-L-arabinofuranose transporter activity Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0140819 GO:0042574 biolink:BiologicalProcess retinal metabolic process The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. go.json retinal metabolism|retinaldehyde metabolic process|retinaldehyde metabolism http://purl.obolibrary.org/obo/GO_0042574 GO:0042573 biolink:BiologicalProcess retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. go.json retinoic acid metabolism|vitamin A1 acid metabolic process|vitamin A1 acid metabolism http://purl.obolibrary.org/obo/GO_0042573 GO:0140810 biolink:MolecularActivity histone H1R54 arginine deiminase activity Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54. go.json H1-R54 citrullination|histone H1-R54 deiminase activity|histone-arginine deiminase activity (H1-R54 specific) http://purl.obolibrary.org/obo/GO_0140810 GO:0042576 biolink:MolecularActivity obsolete aspartyl aminopeptidase activity OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate. go.json aspartyl aminopeptidase activity True http://purl.obolibrary.org/obo/GO_0042576 GO:0042575 biolink:CellularComponent DNA polymerase complex A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. go.json http://purl.obolibrary.org/obo/GO_0042575 goslim_metagenomics|goslim_pir GO:0140812 biolink:MolecularActivity orotate:monoatomic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out). go.json orotate:anion antiporter activity|orotate:organic anion antiporter activity http://purl.obolibrary.org/obo/GO_0140812 GO:0042570 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042570 GO:0140811 biolink:MolecularActivity histone H2AR3 arginine deiminase activity Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3. go.json H2A-R3 citrullination|histone H2A-R3 arginine deiminase activity|histone-arginine deiminase activity (H2A-R3 specific) http://purl.obolibrary.org/obo/GO_0140811 GO:0140814 biolink:MolecularActivity glycine betaine:sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in). RHEA:71175 go.json sodium/chloride-dependent glycine betaine transporter activity http://purl.obolibrary.org/obo/GO_0140814 GO:0042572 biolink:BiologicalProcess retinol metabolic process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. Wikipedia:Retinol go.json retinol metabolism|vitamin A1 alcohol metabolic process|vitamin A1 alcohol metabolism|vitamin A1 metabolic process|vitamin A1 metabolism http://purl.obolibrary.org/obo/GO_0042572 GO:0140813 biolink:MolecularActivity urate:monoatomic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out). go.json urate:anion antiporter activity|urate:organic anion antiporter activity http://purl.obolibrary.org/obo/GO_0140813 GO:0042571 biolink:CellularComponent immunoglobulin complex, circulating An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. Wikipedia:Antibody go.json antibody http://purl.obolibrary.org/obo/GO_0042571 GO:0042578 biolink:MolecularActivity phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. go.json http://purl.obolibrary.org/obo/GO_0042578 GO:0042577 biolink:MolecularActivity lipid phosphatase activity Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. go.json http://purl.obolibrary.org/obo/GO_0042577 GO:0042579 biolink:CellularComponent microbody Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). Wikipedia:Microbody go.json http://purl.obolibrary.org/obo/GO_0042579 goslim_pir GO:0140849 biolink:MolecularActivity ATP-dependent H2AZ histone chaperone activity A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite. go.json ATP-dependent H2A.Z histone chaperone activity|H2AZ histone exchange activity http://purl.obolibrary.org/obo/GO_0140849 GO:0140848 biolink:MolecularActivity amino acid:monoatomic cation antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc. go.json http://purl.obolibrary.org/obo/GO_0140848 GO:0042585 biolink:CellularComponent germinal vesicle The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. go.json primary oocyte nucleus http://purl.obolibrary.org/obo/GO_0042585 GO:0140841 biolink:MolecularActivity RNA polymerase II C-terminal domain O-GlcNAc transferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine. go.json http://purl.obolibrary.org/obo/GO_0140841 GO:0042584 biolink:CellularComponent chromaffin granule membrane The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. go.json http://purl.obolibrary.org/obo/GO_0042584 GO:0140840 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat P6 isomerase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6). go.json RNA polymerase II C-terminal domain P6 isomerase activity http://purl.obolibrary.org/obo/GO_0140840 GO:0140843 biolink:MolecularActivity RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7). go.json http://purl.obolibrary.org/obo/GO_0140843 GO:0042587 biolink:CellularComponent glycogen granule Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. NIF_Subcellular:sao1081228141 go.json glycogen particle http://purl.obolibrary.org/obo/GO_0042587 GO:0042586 biolink:MolecularActivity peptide deformylase activity Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. EC:3.5.1.88|MetaCyc:3.5.1.88-RXN|RHEA:24420 go.json PDF activity|formyl-L-methionyl peptide amidohydrolase activity|polypeptide deformylase activity http://purl.obolibrary.org/obo/GO_0042586 GO:0140842 biolink:MolecularActivity RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5). go.json http://purl.obolibrary.org/obo/GO_0140842 GO:0140845 biolink:BiologicalProcess regulation of promoter clearance from RNA polymerase II promoter A process that modulates the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II. go.json http://purl.obolibrary.org/obo/GO_0140845 GO:0042581 biolink:CellularComponent specific granule Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. Wikipedia:Specific_granule go.json secondary granule http://purl.obolibrary.org/obo/GO_0042581 GO:0140844 biolink:MolecularActivity NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue). go.json NAD+-histone H2B-E2 glutamate ADP-ribosyltransferase activity|NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E2 specific) http://purl.obolibrary.org/obo/GO_0140844 GO:0042580 biolink:CellularComponent mannosome A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction. go.json http://purl.obolibrary.org/obo/GO_0042580 GO:0140847 biolink:BiologicalProcess negative regulation of promoter clearance from RNA polymerase II promoter A process that stops, prevents or reduces the transition from the initiation to the elongation phases of transcription by RNA polymerase II. go.json http://purl.obolibrary.org/obo/GO_0140847 GO:0042583 biolink:CellularComponent chromaffin granule Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. go.json http://purl.obolibrary.org/obo/GO_0042583 GO:0140846 biolink:BiologicalProcess positive regulation of promoter clearance from RNA polymerase II promoter A process that activates or increases the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II. go.json http://purl.obolibrary.org/obo/GO_0140846 GO:0042582 biolink:CellularComponent azurophil granule Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. go.json primary granule http://purl.obolibrary.org/obo/GO_0042582 GO:0042589 biolink:CellularComponent zymogen granule membrane The lipid bilayer surrounding a zymogen granule. go.json http://purl.obolibrary.org/obo/GO_0042589 GO:0042588 biolink:CellularComponent zymogen granule A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. go.json http://purl.obolibrary.org/obo/GO_0042588 GO:0140838 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0). go.json http://purl.obolibrary.org/obo/GO_0140838 GO:0140837 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat S7 kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7). go.json RNA polymerase II C-terminal domain S7 kinase activity http://purl.obolibrary.org/obo/GO_0140837 GO:0042590 biolink:BiologicalProcess antigen processing and presentation of exogenous peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. go.json antigen presentation, exogenous antigen via MHC class I|antigen presentation, exogenous antigen via major histocompatibility complex class I|cross presentation|cross priming|cross-presentation|cross-priming|exogenous peptide antigen processing and presentation via MHC class I http://purl.obolibrary.org/obo/GO_0042590 GO:0140839 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat P3 isomerase activity Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3). go.json RNA polymerase II C-terminal domain P3 isomerase activity http://purl.obolibrary.org/obo/GO_0140839 GO:0042596 biolink:BiologicalProcess fear response The response of an organism to a perceived external threat. go.json physiological fear response http://purl.obolibrary.org/obo/GO_0042596 GO:0140830 biolink:MolecularActivity L-glutamine, sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in). RHEA:71127 go.json http://purl.obolibrary.org/obo/GO_0140830 GO:0042595 biolink:BiologicalProcess behavioral response to starvation Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment. go.json behavioural response to starvation http://purl.obolibrary.org/obo/GO_0042595 GO:0140832 biolink:MolecularActivity L-histidine, sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in). RHEA:71135 go.json http://purl.obolibrary.org/obo/GO_0140832 GO:0042598 biolink:CellularComponent obsolete vesicular fraction OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized. go.json vesicular fraction True http://purl.obolibrary.org/obo/GO_0042598 GO:0042597 biolink:CellularComponent periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). go.json periplasm http://purl.obolibrary.org/obo/GO_0042597 goslim_metagenomics|goslim_pir|prokaryote_subset GO:0140831 biolink:MolecularActivity L-asparagine, sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in). RHEA:71131 go.json http://purl.obolibrary.org/obo/GO_0140831 GO:0042592 biolink:BiologicalProcess homeostatic process Any biological process involved in the maintenance of an internal steady state. go.json activation of homeostatic process|homeostasis|inhibition of homeostatic process|negative regulation of homeostatic process|positive regulation of homeostatic process|regulation of homeostatic process http://purl.obolibrary.org/obo/GO_0042592 goslim_agr|goslim_chembl|goslim_mouse GO:0140834 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat S2 kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2). go.json RNA polymerase II C-terminal domain S2 kinase activity http://purl.obolibrary.org/obo/GO_0140834 GO:0140833 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat Y1 kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1). go.json RNA polymerase II C-terminal domain Y1 kinase activity http://purl.obolibrary.org/obo/GO_0140833 GO:0042591 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042591 GO:0042594 biolink:BiologicalProcess response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. go.json http://purl.obolibrary.org/obo/GO_0042594 goslim_yeast GO:0140836 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat S5 kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5). go.json RNA polymerase II C-terminal domain S5 kinase activity http://purl.obolibrary.org/obo/GO_0140836 GO:0042593 biolink:BiologicalProcess glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. go.json http://purl.obolibrary.org/obo/GO_0042593 GO:0140835 biolink:MolecularActivity RNA polymerase II CTD heptapeptide repeat T4 kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4). go.json RNA polymerase II C-terminal domain T4 kinase activity http://purl.obolibrary.org/obo/GO_0140835 GO:0042599 biolink:CellularComponent lamellar body A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. NIF_Subcellular:sao1379604862 go.json Odland body|keratinosome|lamellar granule|membrane-coating granule http://purl.obolibrary.org/obo/GO_0042599 GO:0140896 biolink:BiologicalProcess cGAS/STING signaling pathway The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING. go.json http://purl.obolibrary.org/obo/GO_0140896 GO:0140895 biolink:BiologicalProcess cell surface toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR) of the toll-like family. go.json cell surface TLR signaling pathway http://purl.obolibrary.org/obo/GO_0140895 GO:0140898 biolink:BiologicalProcess CENP-A eviction from euchromatin A chromatin remodeling process in which CENP-A is removed from euchromatin regions to prevent neocentromere formation. go.json http://purl.obolibrary.org/obo/GO_0140898 GO:0140897 biolink:MolecularActivity mechanoreceptor activity Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. go.json http://purl.obolibrary.org/obo/GO_0140897 GO:0140899 biolink:BiologicalProcess plastid gene expression The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. go.json http://purl.obolibrary.org/obo/GO_0140899 GO:0140890 biolink:MolecularActivity H1 histone chaperone activity A histone chaperone that carries a H1 histone. go.json H1 histone carrier activity http://purl.obolibrary.org/obo/GO_0140890 GO:0140892 biolink:MolecularActivity sodium,bicarbonate:chloride antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in). TC:2.A.31.2.4 go.json sodium-dependent chloride/bicarbonate exchanger activity http://purl.obolibrary.org/obo/GO_0140892 GO:0140891 biolink:BiologicalProcess tRNA-derived regulatory ncRNA processing A process leading to the generation of a functional small regulatory non-coding RNA derived from a tRNA. go.json tRNA-derived small RNA processing http://purl.obolibrary.org/obo/GO_0140891 GO:0140894 biolink:BiologicalProcess endolysosomal toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to an endolysosomal pattern recognition receptor (PRR) of the toll-like family. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. go.json endolysosomal pattern recognition receptor signaling pathway http://purl.obolibrary.org/obo/GO_0140894 GO:0140893 biolink:MolecularActivity neutral amino acid, sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in). TC:2.A.18.6.8 go.json amino acid-coupled Na+/H+ exchanger activity http://purl.obolibrary.org/obo/GO_0140893 GO:0042505 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042505 GO:0042504 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042504 GO:0042507 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042507 GO:0042506 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042506 GO:0042501 biolink:BiologicalProcess serine phosphorylation of STAT protein The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json serine phosphorylation of STAT3 protein http://purl.obolibrary.org/obo/GO_0042501 gocheck_do_not_annotate GO:0042500 biolink:MolecularActivity aspartic endopeptidase activity, intramembrane cleaving Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. EC:3.4.23.-|Reactome:R-HSA-8863101|Reactome:R-HSA-9708457 go.json http://purl.obolibrary.org/obo/GO_0042500 GO:0042503 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042503 GO:0042502 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042502 GO:0042509 biolink:BiologicalProcess regulation of tyrosine phosphorylation of STAT protein Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json regulation of tyrosine phosphorylation of Stat1 protein|regulation of tyrosine phosphorylation of Stat2 protein|regulation of tyrosine phosphorylation of Stat3 protein|regulation of tyrosine phosphorylation of Stat4 protein|regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat6 protein|regulation of tyrosine phosphorylation of Stat7 protein http://purl.obolibrary.org/obo/GO_0042509 GO:0042508 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042508 GO:0042510 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042510 GO:0042516 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042516 GO:0042515 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042515 GO:0042518 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042518 GO:0042517 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042517 GO:0042512 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042512 GO:0042511 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042511 GO:0042514 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042514 GO:0042513 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042513 GO:0042519 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0042519 GO:0061801 biolink:CellularComponent laminin-5B complex A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains. go.json laminin 3B32 complex http://purl.obolibrary.org/obo/GO_0061801 GO:0061800 biolink:CellularComponent fibronectin fibril A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks. go.json http://purl.obolibrary.org/obo/GO_0061800 GO:0061803 biolink:CellularComponent posterior cell cortex The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis. go.json http://purl.obolibrary.org/obo/GO_0061803 GO:0061802 biolink:CellularComponent anterior cell cortex The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis. go.json http://purl.obolibrary.org/obo/GO_0061802 GO:0061805 biolink:BiologicalProcess mitotic spindle elongation (spindle phase three) The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B. go.json mitotic anaphase spindle elongation|mitotic spindle elongation during anaphase|mitotic spindle elongation during mitotic anaphase http://purl.obolibrary.org/obo/GO_0061805 GO:0061804 biolink:BiologicalProcess mitotic spindle formation (spindle phase one) The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase. go.json mitotic spindle elongation during mitotic prophase|mitotic spindle elongation during prophase|mitotic spindle elongation during prophase and prometaphase http://purl.obolibrary.org/obo/GO_0061804 GO:0061807 biolink:BiologicalProcess positive regulation of DNA recombination at centromere Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere. go.json positive regulation of centromeric recombination http://purl.obolibrary.org/obo/GO_0061807 GO:0061806 biolink:BiologicalProcess regulation of DNA recombination at centromere Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA. go.json regulation of centromeric recombination http://purl.obolibrary.org/obo/GO_0061806 GO:0061809 biolink:MolecularActivity NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity. EC:3.2.2.6|MetaCyc:NADNUCLEOSID-RXN go.json http://purl.obolibrary.org/obo/GO_0061809 GO:0061808 biolink:BiologicalProcess negative regulation of DNA recombination at centromere Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere. go.json negative regulation of centromeric recombination http://purl.obolibrary.org/obo/GO_0061808 GO:0061821 biolink:MolecularActivity telomeric D-loop binding Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. go.json telomeric Displacement-loop binding http://purl.obolibrary.org/obo/GO_0061821 GO:0061820 biolink:BiologicalProcess telomeric D-loop disassembly A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. go.json http://purl.obolibrary.org/obo/GO_0061820 GO:0061823 biolink:CellularComponent ring centriole A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum. go.json http://purl.obolibrary.org/obo/GO_0061823 GO:0061822 biolink:CellularComponent ciliary cap An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole. go.json spermatid ciliary cap http://purl.obolibrary.org/obo/GO_0061822 GO:0061825 biolink:CellularComponent podosome core The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. go.json http://purl.obolibrary.org/obo/GO_0061825 GO:0061824 biolink:BiologicalProcess cytosolic ciliogenesis The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm. go.json intracellular ciliogenesis http://purl.obolibrary.org/obo/GO_0061824 GO:0061827 biolink:CellularComponent sperm head The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. go.json http://purl.obolibrary.org/obo/GO_0061827 GO:0061826 biolink:CellularComponent podosome ring The ring structure surrounding the podosome core, containing proteins such as vinculin and talin. go.json http://purl.obolibrary.org/obo/GO_0061826 GO:0061829 biolink:CellularComponent basal tubulobulbar complex Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell. go.json basal TBC http://purl.obolibrary.org/obo/GO_0061829 GO:0061828 biolink:CellularComponent apical tubulobulbar complex Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell. go.json apical TBC http://purl.obolibrary.org/obo/GO_0061828 GO:0061810 biolink:MolecularActivity NAD glycohydrolase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate. EC:3.2.2.5|Reactome:R-HSA-9637699 go.json http://purl.obolibrary.org/obo/GO_0061810 GO:0061812 biolink:MolecularActivity cyclic ADP-ribose hydrolase Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR). go.json http://purl.obolibrary.org/obo/GO_0061812 GO:0061811 biolink:MolecularActivity ADP-ribosyl cyclase activity Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide. go.json http://purl.obolibrary.org/obo/GO_0061811 GO:0061814 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061814 GO:0061813 biolink:MolecularActivity obsolete ARID domain binding OBSOLETE. Binding to a ARID domain. The AT-rich interaction domain (ARID) is an ~100-amino acid DNA-binding module found in a large number of eukaryotic transcription factors. go.json True http://purl.obolibrary.org/obo/GO_0061813 GO:0061816 biolink:BiologicalProcess proteaphagy The selective degradation of proteasomes by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0061816 GO:0061815 biolink:MolecularActivity Met1-linked polyubiquitin deubiquitinase activity Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains. Reactome:R-HSA-9818975 go.json Met1 linkage specific DUB|cysteine-type deubiquitinase activity, acting on linear ubiquitin|deubiquitinase, acting on linear ubiquitin|linear ubiquitin specific deubiquitinase activity|ubiquitinyl hydrolase activity, acting on linear ubiquitin http://purl.obolibrary.org/obo/GO_0061815 GO:0061818 biolink:BiologicalProcess tRNA folding The process of assisting in the folding of tRNAs into the correct tertiary structure. go.json http://purl.obolibrary.org/obo/GO_0061818 GO:0061817 biolink:BiologicalProcess endoplasmic reticulum-plasma membrane tethering The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. go.json ER-plasma membrane tethering http://purl.obolibrary.org/obo/GO_0061817 GO:0061819 biolink:BiologicalProcess telomeric DNA-containing double minutes formation A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase. go.json TDMs formation http://purl.obolibrary.org/obo/GO_0061819 GO:0071198 biolink:CellularComponent Kv4.1-DPP6 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1. CORUM:600 go.json Kv4.1-DPPX channel complex http://purl.obolibrary.org/obo/GO_0071198 GO:0071197 biolink:CellularComponent Kv4.2-Kv4.3 channel complex A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3. CORUM:609 go.json http://purl.obolibrary.org/obo/GO_0071197 GO:0071196 biolink:CellularComponent Kv4.3-KChIP1 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3. CORUM:3091 go.json http://purl.obolibrary.org/obo/GO_0071196 GO:0071195 biolink:CellularComponent Kv4.2-KChIP4 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2. CORUM:3090 go.json http://purl.obolibrary.org/obo/GO_0071195 GO:0071194 biolink:CellularComponent Kv4.2-KChIP3 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2. CORUM:608 go.json http://purl.obolibrary.org/obo/GO_0071194 GO:0071193 biolink:CellularComponent Kv4.2-KChIP2 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2. CORUM:607 go.json http://purl.obolibrary.org/obo/GO_0071193 GO:0071192 biolink:CellularComponent Kv4.2-KChIP1 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2. CORUM:606 go.json http://purl.obolibrary.org/obo/GO_0071192 GO:0071191 biolink:CellularComponent protocadherin-alpha-v7-protocadherin-gamma-b4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdha7-Pcdhgb2 complex http://purl.obolibrary.org/obo/GO_0071191 GO:0071190 biolink:CellularComponent protocadherin-alpha-v7-protocadherin-gamma-b2 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdha7-Pcdhgb4 complex http://purl.obolibrary.org/obo/GO_0071190 GO:0071199 biolink:CellularComponent Kv4.1-DPP10 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1. CORUM:601 go.json Kv4.1-DPPY channel complex http://purl.obolibrary.org/obo/GO_0071199 GO:0046165 biolink:BiologicalProcess alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. go.json alcohol anabolism|alcohol biosynthesis|alcohol formation|alcohol synthesis http://purl.obolibrary.org/obo/GO_0046165 GO:0071121 biolink:CellularComponent alpha9-beta1 integrin-VEGF-D complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D. go.json ITGA9-ITGB1-FIGF complex http://purl.obolibrary.org/obo/GO_0071121 GO:0071120 biolink:CellularComponent alpha4-beta1 integrin-CD47 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47. go.json ITGA4-ITGB1-CB47 complex http://purl.obolibrary.org/obo/GO_0071120 GO:0046164 biolink:BiologicalProcess alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. go.json alcohol breakdown|alcohol catabolism|alcohol degradation http://purl.obolibrary.org/obo/GO_0046164 GO:0046163 biolink:BiologicalProcess heme C catabolic process The chemical reactions and pathways resulting in the breakdown of heme C, a derivative of heme found in cytochromes c, b4, and f. go.json haem C catabolic process|haem C catabolism|heme C breakdown|heme C catabolism|heme C degradation http://purl.obolibrary.org/obo/GO_0046163 GO:0046162 biolink:BiologicalProcess heme C metabolic process The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f. go.json haem C metabolic process|haem C metabolism|heme C metabolism http://purl.obolibrary.org/obo/GO_0046162 GO:0046161 biolink:BiologicalProcess heme a catabolic process The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3. go.json haem a catabolic process|haem a catabolism|heme a breakdown|heme a catabolism|heme a degradation http://purl.obolibrary.org/obo/GO_0046161 GO:1900239 biolink:BiologicalProcess regulation of phenotypic switching Any process that modulates the frequency, rate or extent of phenotypic switching. go.json regulation of phenotypic dimorphism http://purl.obolibrary.org/obo/GO_1900239 GO:1900238 biolink:BiologicalProcess regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway. go.json regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway|regulation of metanephric mesenchyme chemotaxis by platelet-derived growth factor receptor-beta signaling pathway http://purl.obolibrary.org/obo/GO_1900238 GO:0046160 biolink:BiologicalProcess heme a metabolic process The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3. go.json haem a metabolic process|haem a metabolism|heme a metabolism http://purl.obolibrary.org/obo/GO_0046160 GO:1900235 biolink:BiologicalProcess negative regulation of Kit signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway. go.json down regulation of Kit signaling pathway|down regulation of stem cell factor receptor signaling pathway|down regulation of stem cell factor signaling pathway|down-regulation of Kit signaling pathway|down-regulation of stem cell factor receptor signaling pathway|down-regulation of stem cell factor signaling pathway|downregulation of Kit signaling pathway|downregulation of stem cell factor receptor signaling pathway|downregulation of stem cell factor signaling pathway|inhibition of Kit signaling pathway|inhibition of stem cell factor receptor signaling pathway|inhibition of stem cell factor signaling pathway|negative regulation of Kit signalling pathway|negative regulation of stem cell factor receptor signaling pathway|negative regulation of stem cell factor signaling pathway http://purl.obolibrary.org/obo/GO_1900235 GO:1900234 biolink:BiologicalProcess regulation of Kit signaling pathway Any process that modulates the frequency, rate or extent of Kit signaling pathway. go.json regulation of Kit signalling pathway|regulation of stem cell factor receptor signaling pathway|regulation of stem cell factor signaling pathway http://purl.obolibrary.org/obo/GO_1900234 GO:1900237 biolink:BiologicalProcess positive regulation of induction of conjugation with cellular fusion Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion. go.json up regulation of induction of conjugation with cellular fusion|up-regulation of induction of conjugation with cellular fusion|upregulation of induction of conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_1900237 GO:1900236 biolink:BiologicalProcess positive regulation of Kit signaling pathway Any process that activates or increases the frequency, rate or extent of Kit signaling pathway. go.json activation of Kit signaling pathway|activation of stem cell factor receptor signaling pathway|activation of stem cell factor signaling pathway|positive regulation of Kit signalling pathway|positive regulation of stem cell factor receptor signaling pathway|positive regulation of stem cell factor signaling pathway|up regulation of Kit signaling pathway|up regulation of stem cell factor receptor signaling pathway|up regulation of stem cell factor signaling pathway|up-regulation of Kit signaling pathway|up-regulation of stem cell factor receptor signaling pathway|up-regulation of stem cell factor signaling pathway|upregulation of Kit signaling pathway|upregulation of stem cell factor receptor signaling pathway|upregulation of stem cell factor signaling pathway http://purl.obolibrary.org/obo/GO_1900236 GO:1900231 biolink:BiologicalProcess regulation of single-species biofilm formation on inanimate substrate Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate. go.json http://purl.obolibrary.org/obo/GO_1900231 GO:0046169 biolink:BiologicalProcess methanol biosynthetic process The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. go.json methanol anabolism|methanol biosynthesis|methanol formation|methanol synthesis http://purl.obolibrary.org/obo/GO_0046169 GO:1900230 biolink:BiologicalProcess positive regulation of single-species biofilm formation in or on host organism Any process that activates or increases the frequency, rate or extent of single-species biofilm formation in or on host organism. go.json activation of single-species biofilm formation in or on host organism|up regulation of single-species biofilm formation in or on host organism|up-regulation of single-species biofilm formation in or on host organism|upregulation of single-species biofilm formation in or on host organism http://purl.obolibrary.org/obo/GO_1900230 GO:0046168 biolink:BiologicalProcess glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. go.json glycerol-3-phosphate breakdown|glycerol-3-phosphate catabolism|glycerol-3-phosphate degradation http://purl.obolibrary.org/obo/GO_0046168 GO:0046167 biolink:BiologicalProcess glycerol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol. go.json glycerol-3-phosphate anabolism|glycerol-3-phosphate biosynthesis|glycerol-3-phosphate formation|glycerol-3-phosphate synthesis http://purl.obolibrary.org/obo/GO_0046167 GO:1900233 biolink:BiologicalProcess positive regulation of single-species biofilm formation on inanimate substrate Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate. go.json activation of single-species biofilm formation on inanimate substrate|up regulation of single-species biofilm formation on inanimate substrate|up-regulation of single-species biofilm formation on inanimate substrate|upregulation of single-species biofilm formation on inanimate substrate http://purl.obolibrary.org/obo/GO_1900233 GO:0046166 biolink:BiologicalProcess glyceraldehyde-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. go.json glyceraldehyde 3-phosphate biosynthesis|glyceraldehyde 3-phosphate biosynthetic process|glyceraldehyde-3-phosphate anabolism|glyceraldehyde-3-phosphate biosynthesis|glyceraldehyde-3-phosphate formation|glyceraldehyde-3-phosphate synthesis http://purl.obolibrary.org/obo/GO_0046166 GO:1900232 biolink:BiologicalProcess negative regulation of single-species biofilm formation on inanimate substrate Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate. go.json down regulation of single-species biofilm formation on inanimate substrate|down-regulation of single-species biofilm formation on inanimate substrate|downregulation of single-species biofilm formation on inanimate substrate|inhibition of single-species biofilm formation on inanimate substrate http://purl.obolibrary.org/obo/GO_1900232 GO:1900240 biolink:BiologicalProcess negative regulation of phenotypic switching Any process that stops, prevents or reduces the frequency, rate or extent of phenotypic switching. go.json down regulation of phenotypic dimorphism|down regulation of phenotypic switching|down-regulation of phenotypic dimorphism|down-regulation of phenotypic switching|downregulation of phenotypic dimorphism|downregulation of phenotypic switching|inhibition of phenotypic dimorphism|inhibition of phenotypic switching|negative regulation of phenotypic dimorphism http://purl.obolibrary.org/obo/GO_1900240 GO:0071129 biolink:CellularComponent alphaV-beta3 integrin-LPP3 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3. go.json ITGAV-ITGB3-PPAP2B complex http://purl.obolibrary.org/obo/GO_0071129 GO:0071128 biolink:CellularComponent alpha5-beta1 integrin-osteopontin complex A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin. go.json ITGA5-ITGB1-SPP1 complex http://purl.obolibrary.org/obo/GO_0071128 GO:0071127 biolink:CellularComponent alpha9-beta1 integrin-osteopontin complex A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin. go.json ITGA9-ITGB1-SPP1 complex http://purl.obolibrary.org/obo/GO_0071127 GO:0071126 biolink:CellularComponent alphaV-beta6 integrin-osteopontin complex A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin. go.json ITGAV-ITGB6-SPP1 complex http://purl.obolibrary.org/obo/GO_0071126 GO:0071125 biolink:CellularComponent alphaV-beta3 integrin-EGFR complex A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor. go.json ITGAV-ITGB3-EGFR complex http://purl.obolibrary.org/obo/GO_0071125 GO:0071124 biolink:CellularComponent alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2. go.json ITGA1-ITGB1-PTPN2 complex http://purl.obolibrary.org/obo/GO_0071124 GO:0071123 biolink:CellularComponent alpha9-beta1 integrin-VEGF-C complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C. go.json ITGA9-ITGB1-VEGFC complex http://purl.obolibrary.org/obo/GO_0071123 GO:0071122 biolink:CellularComponent alpha9-beta1 integrin-VEGF-A complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A. go.json ITGA9-ITGB1-VEGFA complex http://purl.obolibrary.org/obo/GO_0071122 GO:0071110 biolink:BiologicalProcess obsolete histone biotinylation OBSOLETE. The modification of a histone by the addition of a biotinyl group. go.json True http://purl.obolibrary.org/obo/GO_0071110 GO:0046176 biolink:BiologicalProcess aldonic acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. go.json aldonic acid breakdown|aldonic acid catabolism|aldonic acid degradation http://purl.obolibrary.org/obo/GO_0046176 GO:0046175 biolink:BiologicalProcess aldonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. go.json aldonic acid anabolism|aldonic acid biosynthesis|aldonic acid formation|aldonic acid synthesis http://purl.obolibrary.org/obo/GO_0046175 GO:0046174 biolink:BiologicalProcess polyol catabolic process The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. go.json polyhydric alcohol catabolic process|polyol breakdown|polyol catabolism|polyol degradation http://purl.obolibrary.org/obo/GO_0046174 GO:0046173 biolink:BiologicalProcess polyol biosynthetic process The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. go.json polyhydric alcohol biosynthetic process|polyol anabolism|polyol biosynthesis|polyol formation|polyol synthesis http://purl.obolibrary.org/obo/GO_0046173 GO:0046172 biolink:BiologicalProcess octanol catabolic process The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH. go.json octanol breakdown|octanol catabolism|octanol degradation http://purl.obolibrary.org/obo/GO_0046172 GO:1900249 biolink:BiologicalProcess positive regulation of cytoplasmic translational elongation Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation. go.json activation of cytoplasmic translational elongation|up regulation of cytoplasmic translational elongation|up-regulation of cytoplasmic translational elongation|upregulation of cytoplasmic translational elongation http://purl.obolibrary.org/obo/GO_1900249 GO:0046171 biolink:BiologicalProcess octanol biosynthetic process The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH. go.json octanol anabolism|octanol biosynthesis|octanol formation|octanol synthesis http://purl.obolibrary.org/obo/GO_0046171 GO:0046170 biolink:BiologicalProcess methanol catabolic process The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. go.json methanol breakdown|methanol catabolism|methanol degradation http://purl.obolibrary.org/obo/GO_0046170 GO:1900246 biolink:BiologicalProcess positive regulation of RIG-I signaling pathway Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway. go.json activation of DDX58 signaling pathway|activation of RIG-I signaling pathway|activation of retinoic acid inducible gene I signaling pathway|positive regulation of DDX58 signaling pathway|positive regulation of RIG-I signalling pathway|positive regulation of retinoic acid inducible gene I signaling pathway|up regulation of DDX58 signaling pathway|up regulation of RIG-I signaling pathway|up regulation of retinoic acid inducible gene I signaling pathway|up-regulation of DDX58 signaling pathway|up-regulation of RIG-I signaling pathway|up-regulation of retinoic acid inducible gene I signaling pathway|upregulation of DDX58 signaling pathway|upregulation of RIG-I signaling pathway|upregulation of retinoic acid inducible gene I signaling pathway http://purl.obolibrary.org/obo/GO_1900246 GO:1900245 biolink:BiologicalProcess positive regulation of MDA-5 signaling pathway Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway. go.json activation of IFIH1 signaling pathway|activation of MDA-5 signaling pathway|activation of MDA5 signaling pathway|activation of melanoma differentiation-associated gene 5 signaling pathway|positive regulation of IFIH1 signaling pathway|positive regulation of MDA-5 signalling pathway|positive regulation of MDA5 signaling pathway|positive regulation of melanoma differentiation-associated gene 5 signaling pathway|up regulation of IFIH1 signaling pathway|up regulation of MDA-5 signaling pathway|up regulation of MDA5 signaling pathway|up regulation of melanoma differentiation-associated gene 5 signaling pathway|up-regulation of IFIH1 signaling pathway|up-regulation of MDA-5 signaling pathway|up-regulation of MDA5 signaling pathway|up-regulation of melanoma differentiation-associated gene 5 signaling pathway|upregulation of IFIH1 signaling pathway|upregulation of MDA-5 signaling pathway|upregulation of MDA5 signaling pathway|upregulation of melanoma differentiation-associated gene 5 signaling pathway http://purl.obolibrary.org/obo/GO_1900245 GO:1900248 biolink:BiologicalProcess negative regulation of cytoplasmic translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation. go.json down regulation of cytoplasmic translational elongation|down-regulation of cytoplasmic translational elongation|downregulation of cytoplasmic translational elongation|inhibition of cytoplasmic translational elongation http://purl.obolibrary.org/obo/GO_1900248 GO:1900247 biolink:BiologicalProcess regulation of cytoplasmic translational elongation Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation. go.json http://purl.obolibrary.org/obo/GO_1900247 GO:1900242 biolink:BiologicalProcess regulation of synaptic vesicle endocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. go.json regulation of synaptic vesicle retrieval http://purl.obolibrary.org/obo/GO_1900242 goslim_synapse GO:0061791 biolink:MolecularActivity GTPase motor activity A motor activity driven by GTP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0061791 GO:0061790 biolink:BiologicalProcess dense core granule docking The initial attachment of a dense core granule membrane to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0061790 GO:0046179 biolink:BiologicalProcess keto-D-gluconate biosynthetic process The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose. go.json keto-D-gluconate anabolism|keto-D-gluconate biosynthesis|keto-D-gluconate formation|keto-D-gluconate synthesis http://purl.obolibrary.org/obo/GO_0046179 GO:1900241 biolink:BiologicalProcess positive regulation of phenotypic switching Any process that activates or increases the frequency, rate or extent of phenotypic switching. go.json activation of phenotypic dimorphism|activation of phenotypic switching|positive regulation of phenotypic dimorphism|up regulation of phenotypic dimorphism|up regulation of phenotypic switching|up-regulation of phenotypic dimorphism|up-regulation of phenotypic switching|upregulation of phenotypic dimorphism|upregulation of phenotypic switching http://purl.obolibrary.org/obo/GO_1900241 GO:1900244 biolink:BiologicalProcess positive regulation of synaptic vesicle endocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis. go.json activation of synaptic vesicle endocytosis|activation of synaptic vesicle retrieval|positive regulation of synaptic vesicle retrieval|up regulation of synaptic vesicle endocytosis|up regulation of synaptic vesicle retrieval|up-regulation of synaptic vesicle endocytosis|up-regulation of synaptic vesicle retrieval|upregulation of synaptic vesicle endocytosis|upregulation of synaptic vesicle retrieval http://purl.obolibrary.org/obo/GO_1900244 GO:0061793 biolink:CellularComponent chromatin lock complex A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping. go.json nucleosome bridging complex http://purl.obolibrary.org/obo/GO_0061793 GO:0046178 biolink:BiologicalProcess D-gluconate biosynthetic process The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. go.json D-gluconate anabolism|D-gluconate biosynthesis|D-gluconate formation|D-gluconate synthesis http://purl.obolibrary.org/obo/GO_0046178 GO:0046177 biolink:BiologicalProcess D-gluconate catabolic process The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. MetaCyc:GLUCONSUPER-PWY go.json D-gluconate breakdown|D-gluconate catabolism|D-gluconate degradation http://purl.obolibrary.org/obo/GO_0046177 GO:1900243 biolink:BiologicalProcess negative regulation of synaptic vesicle endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis. go.json down regulation of synaptic vesicle endocytosis|down regulation of synaptic vesicle retrieval|down-regulation of synaptic vesicle endocytosis|down-regulation of synaptic vesicle retrieval|downregulation of synaptic vesicle endocytosis|downregulation of synaptic vesicle retrieval|inhibition of synaptic vesicle endocytosis|inhibition of synaptic vesicle retrieval|negative regulation of synaptic vesicle retrieval http://purl.obolibrary.org/obo/GO_1900243 GO:0061792 biolink:BiologicalProcess secretory granule maturation Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. go.json http://purl.obolibrary.org/obo/GO_0061792 GO:0061795 biolink:BiologicalProcess Golgi lumen acidification Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion. go.json Golgi apparatus lumen acidification http://purl.obolibrary.org/obo/GO_0061795 GO:0061794 biolink:BiologicalProcess conidium development The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. go.json http://purl.obolibrary.org/obo/GO_0061794 GO:0061797 biolink:MolecularActivity pH-gated chloride channel activity A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH. go.json http://purl.obolibrary.org/obo/GO_0061797 GO:0061796 biolink:BiologicalProcess membrane addition at site of mitotic cytokinesis A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. go.json http://purl.obolibrary.org/obo/GO_0061796 GO:0061799 biolink:MolecularActivity cyclic pyranopterin monophosphate synthase activity Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate. EC:4.6.1.17|MetaCyc:RXN-17809|RHEA:49580 go.json http://purl.obolibrary.org/obo/GO_0061799 GO:0061798 biolink:MolecularActivity GTP 3',8'-cyclase activity Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. EC:4.1.99.22|MetaCyc:RXN-8340|RHEA:49576 go.json http://purl.obolibrary.org/obo/GO_0061798 GO:0071119 biolink:CellularComponent alpha7-beta1 integrin-nicotinamide riboside kinase complex A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP). go.json ITGA7-ITGB1-ITGB1BP3 complex http://purl.obolibrary.org/obo/GO_0071119 GO:0071118 biolink:CellularComponent alphaV-beta3 integrin-NOV complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV. go.json ITGAV-ITGB3-FN-1-NOV complex http://purl.obolibrary.org/obo/GO_0071118 GO:0071117 biolink:CellularComponent alpha5-beta1 integrin-fibronectin-NOV complex A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV. go.json ITGA5-ITGB1-FN-1-NOV complex http://purl.obolibrary.org/obo/GO_0071117 GO:0071116 biolink:CellularComponent alpha6-beta1 integrin-CYR61 complex A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis. go.json ITGA6-ITGB1-CYR61 complex http://purl.obolibrary.org/obo/GO_0071116 GO:0071115 biolink:CellularComponent alpha5-beta1 integrin-endostatin complex A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen. go.json ITGA5-ITGB1-CAL4A3 complex http://purl.obolibrary.org/obo/GO_0071115 GO:0071114 biolink:CellularComponent alphaV-beta3 integrin-tumstatin complex A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen. go.json ITGAV-ITGB3-COL4A3 complex http://purl.obolibrary.org/obo/GO_0071114 GO:0071113 biolink:CellularComponent alphaIIb-beta3 integrin-ICAM-4 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4. go.json ITGAIIb-ITGB3-ICAM4 complex http://purl.obolibrary.org/obo/GO_0071113 GO:0071112 biolink:CellularComponent alpha4-beta4 integrin-EMILIN-1 complex A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN). go.json ITGA4-ITGB4-EMILIN1 complex http://purl.obolibrary.org/obo/GO_0071112 GO:0071111 biolink:MolecularActivity cyclic-guanylate-specific phosphodiesterase activity Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. EC:3.1.4.52|KEGG_REACTION:R08991|MetaCyc:RXN0-4181|RHEA:24902 go.json PDEA1|VieA|c-di-GMP phosphodiesterase activity|c-di-GMP-specific phosphodiesterase activity|cyclic bis(3->5')diguanylate phosphodiesterase activity|phosphodiesterase A1 activity http://purl.obolibrary.org/obo/GO_0071111 GO:0046187 biolink:BiologicalProcess acetaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. go.json acetaldehyde breakdown|acetaldehyde catabolism|acetaldehyde degradation http://purl.obolibrary.org/obo/GO_0046187 GO:0071143 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071143 GO:0071142 biolink:CellularComponent homomeric SMAD protein complex A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive. go.json SMAD1 homotrimer complex|SMAD1 protein complex|SMAD2 homotrimer complex|SMAD2 protein complex|SMAD3 homotrimer complex|SMAD3 protein complex http://purl.obolibrary.org/obo/GO_0071142 GO:0046186 biolink:BiologicalProcess acetaldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. go.json acetaldehyde anabolism|acetaldehyde biosynthesis|acetaldehyde formation|acetaldehyde synthesis http://purl.obolibrary.org/obo/GO_0046186 GO:0071141 biolink:CellularComponent SMAD protein complex A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. go.json SMAD complex http://purl.obolibrary.org/obo/GO_0071141 GO:0046185 biolink:BiologicalProcess aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. go.json aldehyde breakdown|aldehyde catabolism|aldehyde degradation http://purl.obolibrary.org/obo/GO_0046185 GO:0046184 biolink:BiologicalProcess aldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. go.json aldehyde anabolism|aldehyde biosynthesis|aldehyde formation|aldehyde synthesis http://purl.obolibrary.org/obo/GO_0046184 GO:0071140 biolink:BiologicalProcess resolution of mitotic recombination intermediates The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged. go.json http://purl.obolibrary.org/obo/GO_0071140 GO:0046183 biolink:BiologicalProcess L-idonate catabolic process The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. go.json L-idonate breakdown|L-idonate catabolism|L-idonate degradation http://purl.obolibrary.org/obo/GO_0046183 GO:0046182 biolink:BiologicalProcess L-idonate biosynthetic process The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. go.json L-idonate anabolism|L-idonate biosynthesis|L-idonate formation|L-idonate synthesis http://purl.obolibrary.org/obo/GO_0046182 GO:0046181 biolink:BiologicalProcess ketogluconate catabolic process The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. go.json ketogluconate breakdown|ketogluconate catabolism|ketogluconate degradation http://purl.obolibrary.org/obo/GO_0046181 GO:0046180 biolink:BiologicalProcess ketogluconate biosynthetic process The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. go.json ketogluconate anabolism|ketogluconate biosynthesis|ketogluconate formation|ketogluconate synthesis http://purl.obolibrary.org/obo/GO_0046180 GO:1900257 biolink:BiologicalProcess obsolete negative regulation of beta1-adrenergic receptor activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity. go.json down regulation of beta1 adrenoceptor|down regulation of beta1-adrenergic receptor activity|down-regulation of beta1 adrenoceptor|down-regulation of beta1-adrenergic receptor activity|downregulation of beta1 adrenoceptor|downregulation of beta1-adrenergic receptor activity|inhibition of beta1 adrenoceptor|inhibition of beta1-adrenergic receptor activity|negative regulation of beta1 adrenoceptor True http://purl.obolibrary.org/obo/GO_1900257 GO:1900256 biolink:BiologicalProcess obsolete regulation of beta1-adrenergic receptor activity OBSOLETE. Any process that modulates the frequency, rate or extent of beta1-adrenergic receptor activity. go.json regulation of beta1 adrenoceptor True http://purl.obolibrary.org/obo/GO_1900256 GO:1900259 biolink:BiologicalProcess regulation of RNA-dependent RNA polymerase activity Any process that modulates the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. go.json regulation of 3D polymerase activity|regulation of Q-beta replicase activity|regulation of RDRP|regulation of RNA nucleotidyltransferase (RNA-directed) activity|regulation of RNA replicase activity|regulation of RNA synthetase activity|regulation of RNA-dependent RNA replicase activity|regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|regulation of RNA-directed 5'-3' RNA polymerase activity|regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|regulation of ribonucleic acid replicase activity|regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|regulation of ribonucleic replicase activity|regulation of ribonucleic synthetase activity|regulation of transcriptase http://purl.obolibrary.org/obo/GO_1900259 gocheck_do_not_annotate GO:1900258 biolink:BiologicalProcess obsolete positive regulation of beta1-adrenergic receptor activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity. go.json activation of beta1 adrenoceptor|activation of beta1-adrenergic receptor activity|positive regulation of beta1 adrenoceptor|up regulation of beta1 adrenoceptor|up regulation of beta1-adrenergic receptor activity|up-regulation of beta1 adrenoceptor|up-regulation of beta1-adrenergic receptor activity|upregulation of beta1 adrenoceptor|upregulation of beta1-adrenergic receptor activity True http://purl.obolibrary.org/obo/GO_1900258 GO:0046189 biolink:BiologicalProcess phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. go.json phenol-containing compound anabolism|phenol-containing compound biosynthesis|phenol-containing compound formation|phenol-containing compound synthesis http://purl.obolibrary.org/obo/GO_0046189 GO:0046188 biolink:BiologicalProcess methane catabolic process The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. go.json methane breakdown|methane catabolism|methane degradation http://purl.obolibrary.org/obo/GO_0046188 GO:1900260 biolink:BiologicalProcess negative regulation of RNA-dependent RNA polymerase activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. go.json down regulation of PB1 proteins|down regulation of PB2 proteins|down regulation of RDRP|down regulation of RNA nucleotidyltransferase (RNA-directed) activity|down regulation of RNA replicase activity|down regulation of RNA synthetase activity|down regulation of RNA-dependent RNA polymerase activity|down regulation of RNA-dependent RNA replicase activity|down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|down regulation of RNA-directed RNA polymerase activity|down regulation of phage f2 replicase|down regulation of polymerase L|down regulation of ribonucleic acid replicase activity|down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|down regulation of ribonucleic replicase activity|down regulation of ribonucleic synthetase activity|down regulation of transcriptase|down-regulation of PB1 proteins|down-regulation of PB2 proteins|down-regulation of RDRP|down-regulation of RNA nucleotidyltransferase (RNA-directed) activity|down-regulation of RNA replicase activity|down-regulation of RNA synthetase activity|down-regulation of RNA-dependent RNA polymerase activity|down-regulation of RNA-dependent RNA replicase activity|down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|down-regulation of RNA-directed RNA polymerase activity|down-regulation of phage f2 replicase|down-regulation of polymerase L|down-regulation of ribonucleic acid replicase activity|down-regulation of ribonucleic synthetase activity|down-regulation of transcriptase|downregulation of PB1 proteins|downregulation of PB2 proteins|downregulation of RDRP|downregulation of RNA nucleotidyltransferase (RNA-directed) activity|downregulation of RNA replicase activity|downregulation of RNA synthetase activity|downregulation of RNA-dependent RNA polymerase activity|downregulation of RNA-dependent RNA replicase activity|downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity|downregulation of RNA-directed RNA polymerase activity|downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|downregulation of phage f2 replicase|downregulation of polymerase L|downregulation of ribonucleic acid replicase activity|downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|downregulation of ribonucleic replicase activity|downregulation of ribonucleic synthetase activity|downregulation of transcriptase|inhibition of PB1 proteins|inhibition of PB2 proteins|inhibition of RDRP|inhibition of RNA nucleotidyltransferase (RNA-directed) activity|inhibition of RNA replicase activity|inhibition of RNA synthetase activity|inhibition of RNA-dependent RNA polymerase activity|inhibition of RNA-dependent RNA replicase activity|inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity|inhibition of RNA-directed RNA polymerase activity|inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|inhibition of phage f2 replicase|inhibition of polymerase L|inhibition of ribonucleic acid replicase activity|inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity|inhibition of ribonucleic replicase activity|inhibition of ribonucleic synthetase activity|inhibition of transcriptase|negative regulation of 3D polymerase activity|negative regulation of PB1 proteins|negative regulation of PB2 proteins|negative regulation of RDRP|negative regulation of RNA nucleotidyltransferase (RNA-directed) activity|negative regulation of RNA replicase activity|negative regulation of RNA synthetase activity|negative regulation of RNA-dependent RNA replicase activity|negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|negative regulation of RNA-directed 5'-3' RNA polymerase activity|negative regulation of RNA-directed RNA polymerase activity|negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|negative regulation of phage f2 replicase|negative regulation of polymerase L|negative regulation of ribonucleic acid replicase activity|negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|negative regulation of ribonucleic replicase activity|negative regulation of ribonucleic synthetase activity|negative regulation of transcriptase http://purl.obolibrary.org/obo/GO_1900260 gocheck_do_not_annotate GO:1900262 biolink:BiologicalProcess regulation of DNA-directed DNA polymerase activity Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity. go.json regulation of DNA duplicase activity|regulation of DNA nucleotidyltransferase (DNA-directed) activity|regulation of DNA polymerase I|regulation of DNA polymerase II|regulation of DNA polymerase III|regulation of DNA polymerase V activity|regulation of DNA polymerase alpha|regulation of DNA polymerase beta|regulation of DNA polymerase gamma|regulation of DNA replicase activity|regulation of DNA-dependent DNA polymerase activity|regulation of Klenow fragment|regulation of Taq DNA polymerase|regulation of Taq Pol I|regulation of Tca DNA polymerase|regulation of alpha DNA polymerase activity|regulation of beta DNA polymerase activity|regulation of delta DNA polymerase activity|regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|regulation of deoxyribonucleic acid duplicase activity|regulation of deoxyribonucleic duplicase activity|regulation of deoxyribonucleic polymerase I|regulation of duplicase|regulation of epsilon DNA polymerase activity|regulation of eta DNA polymerase activity|regulation of gamma DNA-directed DNA polymerase activity|regulation of iota DNA polymerase activity|regulation of kappa DNA polymerase activity|regulation of lambda DNA polymerase activity|regulation of mu DNA polymerase activity|regulation of nu DNA polymerase activity|regulation of sequenase|regulation of sigma DNA polymerase activity|regulation of theta DNA polymerase activity|regulation of zeta DNA polymerase activity http://purl.obolibrary.org/obo/GO_1900262 gocheck_do_not_annotate GO:1900261 biolink:BiologicalProcess positive regulation of RNA-dependent RNA polymerase activity Any process that activates or increases the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. go.json activation of 3D polymerase activity|activation of PB1 proteins|activation of PB2 proteins|activation of RDRP|activation of RNA nucleotidyltransferase (RNA-directed) activity|activation of RNA replicase activity|activation of RNA synthetase activity|activation of RNA-dependent RNA polymerase activity|activation of RNA-dependent RNA replicase activity|activation of RNA-dependent ribonucleate nucleotidyltransferase activity|activation of RNA-directed RNA polymerase activity|activation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|activation of phage f2 replicase|activation of polymerase L|activation of ribonucleic acid replicase activity|activation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|activation of ribonucleic acid-dependent ribonucleic acid polymerase activity|activation of ribonucleic replicase activity|activation of ribonucleic synthetase activity|activation of transcriptase|positive regulation of 3D polymerase activity|positive regulation of PB1 proteins|positive regulation of PB2 proteins|positive regulation of RDRP|positive regulation of RNA nucleotidyltransferase (RNA-directed) activity|positive regulation of RNA replicase activity|positive regulation of RNA synthetase activity|positive regulation of RNA-dependent RNA replicase activity|positive regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|positive regulation of RNA-directed 5'-3' RNA polymerase activity|positive regulation of RNA-directed RNA polymerase activity|positive regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|positive regulation of phage f2 replicase|positive regulation of polymerase L|positive regulation of ribonucleic acid replicase activity|positive regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|positive regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|positive regulation of ribonucleic replicase activity|positive regulation of ribonucleic synthetase activity|positive regulation of transcriptase|up regulation of 3D polymerase activity|up regulation of PB1 proteins|up regulation of PB2 proteins|up regulation of Q-beta replicase activity|up regulation of RDRP|up regulation of RNA nucleotidyltransferase (RNA-directed) activity|up regulation of RNA replicase activity|up regulation of RNA synthetase activity|up regulation of RNA-dependent RNA polymerase activity|up regulation of RNA-dependent RNA replicase activity|up regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|up regulation of RNA-directed RNA polymerase activity|up regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|up regulation of phage f2 replicase|up regulation of polymerase L|up regulation of ribonucleic acid replicase activity|up regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|up regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|up regulation of ribonucleic replicase activity|up regulation of ribonucleic synthetase activity|up regulation of transcriptase|up-regulation of 3D polymerase activity|up-regulation of PB1 proteins|up-regulation of PB2 proteins|up-regulation of Q-beta replicase activity|up-regulation of RDRP|up-regulation of RNA nucleotidyltransferase (RNA-directed) activity|up-regulation of RNA replicase activity|up-regulation of RNA synthetase activity|up-regulation of RNA-dependent RNA polymerase activity|up-regulation of RNA-dependent RNA replicase activity|up-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|up-regulation of RNA-directed RNA polymerase activity|up-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|up-regulation of phage f2 replicase|up-regulation of polymerase L|up-regulation of ribonucleic acid replicase activity|up-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|up-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|up-regulation of ribonucleic replicase activity|up-regulation of ribonucleic synthetase activity|up-regulation of transcriptase|upregulation of 3D polymerase activity|upregulation of PB1 proteins|upregulation of PB2 proteins|upregulation of Q-beta replicase activity|upregulation of RDRP|upregulation of RNA nucleotidyltransferase (RNA-directed) activity|upregulation of RNA replicase activity|upregulation of RNA synthetase activity|upregulation of RNA-dependent RNA polymerase activity|upregulation of RNA-dependent RNA replicase activity|upregulation of RNA-dependent ribonucleate nucleotidyltransferase activity|upregulation of RNA-directed RNA polymerase activity|upregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|upregulation of phage f2 replicase|upregulation of polymerase L|upregulation of ribonucleic acid replicase activity|upregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|upregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|upregulation of ribonucleic replicase activity|upregulation of ribonucleic synthetase activity|upregulation of transcriptase http://purl.obolibrary.org/obo/GO_1900261 gocheck_do_not_annotate GO:0046190 biolink:BiologicalProcess aerobic phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. go.json aerobic phenol-containing compound anabolism|aerobic phenol-containing compound biosynthesis|aerobic phenol-containing compound formation|aerobic phenol-containing compound synthesis http://purl.obolibrary.org/obo/GO_0046190 GO:0071149 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071149 GO:0071148 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071148 GO:0071147 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071147 GO:0071146 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071146 GO:0071145 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071145 GO:0071144 biolink:CellularComponent heteromeric SMAD protein complex A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. go.json SMAD1-SMAD4 protein complex|SMAD2-SMAD3-SMAD4 protein complex|SMAD2-SMAD4 protein complex|SMAD3-SMAD4 protein complex http://purl.obolibrary.org/obo/GO_0071144 GO:0071132 biolink:CellularComponent alphaX-beta2 integrin-ICAM-4 complex A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4. go.json ITGAX-ITGB2-ICAM4 complex http://purl.obolibrary.org/obo/GO_0071132 GO:0046198 biolink:BiologicalProcess obsolete cresol biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. go.json cresol anabolism|cresol biosynthesis|cresol biosynthetic process|cresol formation|cresol synthesis True http://purl.obolibrary.org/obo/GO_0046198 GO:0046197 biolink:BiologicalProcess orcinol biosynthetic process The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. go.json orcinol anabolism|orcinol biosynthesis|orcinol formation|orcinol synthesis http://purl.obolibrary.org/obo/GO_0046197 GO:0071131 biolink:CellularComponent alphaV-beta3 integrin-laminin alpha-4 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4. go.json ITGAV-ITGB3-LAMA4 complex http://purl.obolibrary.org/obo/GO_0071131 GO:0046196 biolink:BiologicalProcess 4-nitrophenol catabolic process The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. go.json 4-nitrophenol breakdown|4-nitrophenol catabolism|4-nitrophenol degradation http://purl.obolibrary.org/obo/GO_0046196 GO:0071130 biolink:CellularComponent alpha5-beta1 integrin-LPP3 complex A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3. go.json ITGA5-ITGB1-PPAP2B complex http://purl.obolibrary.org/obo/GO_0071130 GO:0046195 biolink:BiologicalProcess obsolete 4-nitrophenol biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. go.json 4-nitrophenol anabolism|4-nitrophenol biosynthesis|4-nitrophenol biosynthetic process|4-nitrophenol formation|4-nitrophenol synthesis True http://purl.obolibrary.org/obo/GO_0046195 GO:0046194 biolink:BiologicalProcess obsolete pentachlorophenol biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. go.json pentachlorophenol anabolism|pentachlorophenol biosynthesis|pentachlorophenol biosynthetic process|pentachlorophenol formation|pentachlorophenol synthesis True http://purl.obolibrary.org/obo/GO_0046194 GO:0046193 biolink:BiologicalProcess anaerobic phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. go.json anaerobic phenol-containing compound breakdown|anaerobic phenol-containing compound catabolism|anaerobic phenol-containing compound degradation http://purl.obolibrary.org/obo/GO_0046193 GO:0046192 biolink:BiologicalProcess anaerobic phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. go.json anaerobic phenol-containing compound anabolism|anaerobic phenol-containing compound biosynthesis|anaerobic phenol-containing compound formation|anaerobic phenol-containing compound synthesis http://purl.obolibrary.org/obo/GO_0046192 GO:0046191 biolink:BiologicalProcess aerobic phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. go.json aerobic phenol-containing compound breakdown|aerobic phenol-containing compound catabolism|aerobic phenol-containing compound degradation http://purl.obolibrary.org/obo/GO_0046191 GO:1900268 biolink:BiologicalProcess regulation of reverse transcription Any process that modulates the frequency, rate or extent of reverse transcription. go.json http://purl.obolibrary.org/obo/GO_1900268 GO:1900267 biolink:BiologicalProcess positive regulation of substance P receptor binding Any process that activates or increases the frequency, rate or extent of substance P receptor binding. go.json activation of neurokinin-1 receptor binding|activation of substance P receptor binding|activation of substance P receptor ligand|positive regulation of neurokinin-1 receptor binding|positive regulation of substance P receptor ligand|up regulation of neurokinin-1 receptor binding|up regulation of substance P receptor binding|up regulation of substance P receptor ligand|up-regulation of neurokinin-1 receptor binding|up-regulation of substance P receptor binding|up-regulation of substance P receptor ligand|upregulation of neurokinin-1 receptor binding|upregulation of substance P receptor binding|upregulation of substance P receptor ligand http://purl.obolibrary.org/obo/GO_1900267 gocheck_do_not_annotate GO:1900269 biolink:BiologicalProcess negative regulation of reverse transcription Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription. go.json down regulation of reverse transcription|down-regulation of reverse transcription|downregulation of reverse transcription|inhibition of reverse transcription http://purl.obolibrary.org/obo/GO_1900269 GO:1900264 biolink:BiologicalProcess positive regulation of DNA-directed DNA polymerase activity Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity. go.json activation of DNA duplicase activity|activation of DNA nucleotidyltransferase (DNA-directed) activity|activation of DNA polymerase I|activation of DNA polymerase II|activation of DNA polymerase III|activation of DNA polymerase V activity|activation of DNA polymerase alpha|activation of DNA polymerase beta|activation of DNA polymerase gamma|activation of DNA replicase activity|activation of DNA-dependent DNA polymerase activity|activation of DNA-directed DNA polymerase activity|activation of Klenow fragment|activation of Taq DNA polymerase|activation of Taq Pol I|activation of Tca DNA polymerase|activation of alpha DNA polymerase activity|activation of beta DNA polymerase activity|activation of delta DNA polymerase activity|activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|activation of deoxyribonucleic acid duplicase activity|activation of deoxyribonucleic duplicase activity|activation of deoxyribonucleic polymerase I|activation of duplicase|activation of epsilon DNA polymerase activity|activation of eta DNA polymerase activity|activation of gamma DNA-directed DNA polymerase activity|activation of iota DNA polymerase activity|activation of kappa DNA polymerase activity|activation of lambda DNA polymerase activity|activation of mu DNA polymerase activity|activation of nu DNA polymerase activity|activation of sequenase|activation of sigma DNA polymerase activity|activation of theta DNA polymerase activity|activation of zeta DNA polymerase activity|positive regulation of DNA duplicase activity|positive regulation of DNA nucleotidyltransferase (DNA-directed) activity|positive regulation of DNA polymerase I|positive regulation of DNA polymerase II|positive regulation of DNA polymerase III|positive regulation of DNA polymerase V activity|positive regulation of DNA polymerase alpha|positive regulation of DNA polymerase beta|positive regulation of DNA polymerase gamma|positive regulation of DNA replicase activity|positive regulation of DNA-dependent DNA polymerase activity|positive regulation of Klenow fragment|positive regulation of Taq DNA polymerase|positive regulation of Taq Pol I|positive regulation of Tca DNA polymerase|positive regulation of alpha DNA polymerase activity|positive regulation of beta DNA polymerase activity|positive regulation of delta DNA polymerase activity|positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|positive regulation of deoxyribonucleic acid duplicase activity|positive regulation of deoxyribonucleic duplicase activity|positive regulation of deoxyribonucleic polymerase I|positive regulation of duplicase|positive regulation of epsilon DNA polymerase activity|positive regulation of eta DNA polymerase activity|positive regulation of gamma DNA-directed DNA polymerase activity|positive regulation of iota DNA polymerase activity|positive regulation of kappa DNA polymerase activity|positive regulation of lambda DNA polymerase activity|positive regulation of mu DNA polymerase activity|positive regulation of nu DNA polymerase activity|positive regulation of sequenase|positive regulation of sigma DNA polymerase activity|positive regulation of theta DNA polymerase activity|positive regulation of zeta DNA polymerase activity|up regulation of DNA duplicase activity|up regulation of DNA nucleotidyltransferase (DNA-directed) activity|up regulation of DNA polymerase I|up regulation of DNA polymerase II|up regulation of DNA polymerase III|up regulation of DNA polymerase V activity|up regulation of DNA polymerase alpha|up regulation of DNA polymerase beta|up regulation of DNA polymerase gamma|up regulation of DNA replicase activity|up regulation of DNA-dependent DNA polymerase activity|up regulation of DNA-directed DNA polymerase activity|up regulation of Klenow fragment|up regulation of Taq DNA polymerase|up regulation of Taq Pol I|up regulation of Tca DNA polymerase|up regulation of alpha DNA polymerase activity|up regulation of beta DNA polymerase activity|up regulation of delta DNA polymerase activity|up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|up regulation of deoxyribonucleic acid duplicase activity|up regulation of deoxyribonucleic duplicase activity|up regulation of deoxyribonucleic polymerase I|up regulation of duplicase|up regulation of epsilon DNA polymerase activity|up regulation of eta DNA polymerase activity|up regulation of gamma DNA-directed DNA polymerase activity|up regulation of iota DNA polymerase activity|up regulation of kappa DNA polymerase activity|up regulation of lambda DNA polymerase activity|up regulation of mu DNA polymerase activity|up regulation of nu DNA polymerase activity|up regulation of sequenase|up regulation of sigma DNA polymerase activity|up regulation of theta DNA polymerase activity|up regulation of zeta DNA polymerase activity|up-regulation of DNA duplicase activity|up-regulation of DNA nucleotidyltransferase (DNA-directed) activity|up-regulation of DNA polymerase I|up-regulation of DNA polymerase II|up-regulation of DNA polymerase III|up-regulation of DNA polymerase V activity|up-regulation of DNA polymerase alpha|up-regulation of DNA polymerase beta|up-regulation of DNA polymerase gamma|up-regulation of DNA replicase activity|up-regulation of DNA-dependent DNA polymerase activity|up-regulation of DNA-directed DNA polymerase activity|up-regulation of Klenow fragment|up-regulation of Taq DNA polymerase|up-regulation of Taq Pol I|up-regulation of Tca DNA polymerase|up-regulation of alpha DNA polymerase activity|up-regulation of beta DNA polymerase activity|up-regulation of delta DNA polymerase activity|up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|up-regulation of deoxyribonucleic acid duplicase activity|up-regulation of deoxyribonucleic duplicase activity|up-regulation of deoxyribonucleic polymerase I|up-regulation of duplicase|up-regulation of epsilon DNA polymerase activity|up-regulation of eta DNA polymerase activity|up-regulation of gamma DNA-directed DNA polymerase activity|up-regulation of iota DNA polymerase activity|up-regulation of kappa DNA polymerase activity|up-regulation of lambda DNA polymerase activity|up-regulation of mu DNA polymerase activity|up-regulation of nu DNA polymerase activity|up-regulation of sequenase|up-regulation of sigma DNA polymerase activity|up-regulation of theta DNA polymerase activity|up-regulation of zeta DNA polymerase activity|upregulation of DNA duplicase activity|upregulation of DNA nucleotidyltransferase (DNA-directed) activity|upregulation of DNA polymerase I|upregulation of DNA polymerase II|upregulation of DNA polymerase III|upregulation of DNA polymerase V activity|upregulation of DNA polymerase alpha|upregulation of DNA polymerase beta|upregulation of DNA polymerase gamma|upregulation of DNA replicase activity|upregulation of DNA-dependent DNA polymerase activity|upregulation of DNA-directed DNA polymerase activity|upregulation of Klenow fragment|upregulation of Taq DNA polymerase|upregulation of Taq Pol I|upregulation of Tca DNA polymerase|upregulation of alpha DNA polymerase activity|upregulation of beta DNA polymerase activity|upregulation of delta DNA polymerase activity|upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|upregulation of deoxyribonucleic acid duplicase activity|upregulation of deoxyribonucleic duplicase activity|upregulation of deoxyribonucleic polymerase I|upregulation of duplicase|upregulation of epsilon DNA polymerase activity|upregulation of eta DNA polymerase activity|upregulation of gamma DNA-directed DNA polymerase activity|upregulation of iota DNA polymerase activity|upregulation of kappa DNA polymerase activity|upregulation of lambda DNA polymerase activity|upregulation of mu DNA polymerase activity|upregulation of nu DNA polymerase activity|upregulation of sequenase|upregulation of sigma DNA polymerase activity|upregulation of theta DNA polymerase activity|upregulation of zeta DNA polymerase activity http://purl.obolibrary.org/obo/GO_1900264 gocheck_do_not_annotate GO:1900263 biolink:BiologicalProcess negative regulation of DNA-directed DNA polymerase activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity. go.json down regulation of DNA duplicase activity|down regulation of DNA nucleotidyltransferase (DNA-directed) activity|down regulation of DNA polymerase I|down regulation of DNA polymerase II|down regulation of DNA polymerase III|down regulation of DNA polymerase V activity|down regulation of DNA polymerase alpha|down regulation of DNA polymerase beta|down regulation of DNA polymerase gamma|down regulation of DNA replicase activity|down regulation of DNA-dependent DNA polymerase activity|down regulation of DNA-directed DNA polymerase activity|down regulation of Klenow fragment|down regulation of Taq DNA polymerase|down regulation of Taq Pol I|down regulation of Tca DNA polymerase|down regulation of alpha DNA polymerase activity|down regulation of beta DNA polymerase activity|down regulation of delta DNA polymerase activity|down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|down regulation of deoxyribonucleic acid duplicase activity|down regulation of deoxyribonucleic duplicase activity|down regulation of deoxyribonucleic polymerase I|down regulation of duplicase|down regulation of epsilon DNA polymerase activity|down regulation of eta DNA polymerase activity|down regulation of gamma DNA-directed DNA polymerase activity|down regulation of iota DNA polymerase activity|down regulation of kappa DNA polymerase activity|down regulation of lambda DNA polymerase activity|down regulation of mu DNA polymerase activity|down regulation of nu DNA polymerase activity|down regulation of sequenase|down regulation of sigma DNA polymerase activity|down regulation of theta DNA polymerase activity|down regulation of zeta DNA polymerase activity|down-regulation of DNA duplicase activity|down-regulation of DNA nucleotidyltransferase (DNA-directed) activity|down-regulation of DNA polymerase I|down-regulation of DNA polymerase II|down-regulation of DNA polymerase III|down-regulation of DNA polymerase V activity|down-regulation of DNA polymerase alpha|down-regulation of DNA polymerase beta|down-regulation of DNA polymerase gamma|down-regulation of DNA replicase activity|down-regulation of DNA-dependent DNA polymerase activity|down-regulation of DNA-directed DNA polymerase activity|down-regulation of Klenow fragment|down-regulation of Taq DNA polymerase|down-regulation of Taq Pol I|down-regulation of Tca DNA polymerase|down-regulation of alpha DNA polymerase activity|down-regulation of beta DNA polymerase activity|down-regulation of delta DNA polymerase activity|down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|down-regulation of deoxyribonucleic acid duplicase activity|down-regulation of deoxyribonucleic duplicase activity|down-regulation of deoxyribonucleic polymerase I|down-regulation of duplicase|down-regulation of epsilon DNA polymerase activity|down-regulation of eta DNA polymerase activity|down-regulation of gamma DNA-directed DNA polymerase activity|down-regulation of iota DNA polymerase activity|down-regulation of kappa DNA polymerase activity|down-regulation of lambda DNA polymerase activity|down-regulation of mu DNA polymerase activity|down-regulation of nu DNA polymerase activity|down-regulation of sequenase|down-regulation of sigma DNA polymerase activity|down-regulation of theta DNA polymerase activity|down-regulation of zeta DNA polymerase activity|downregulation of DNA duplicase activity|downregulation of DNA nucleotidyltransferase (DNA-directed) activity|downregulation of DNA polymerase I|downregulation of DNA polymerase II|downregulation of DNA polymerase III|downregulation of DNA polymerase V activity|downregulation of DNA polymerase alpha|downregulation of DNA polymerase beta|downregulation of DNA polymerase gamma|downregulation of DNA replicase activity|downregulation of DNA-dependent DNA polymerase activity|downregulation of DNA-directed DNA polymerase activity|downregulation of Klenow fragment|downregulation of Taq DNA polymerase|downregulation of Taq Pol I|downregulation of Tca DNA polymerase|downregulation of alpha DNA polymerase activity|downregulation of beta DNA polymerase activity|downregulation of delta DNA polymerase activity|downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|downregulation of deoxyribonucleic acid duplicase activity|downregulation of deoxyribonucleic duplicase activity|downregulation of deoxyribonucleic polymerase I|downregulation of duplicase|downregulation of epsilon DNA polymerase activity|downregulation of eta DNA polymerase activity|downregulation of gamma DNA-directed DNA polymerase activity|downregulation of iota DNA polymerase activity|downregulation of kappa DNA polymerase activity|downregulation of lambda DNA polymerase activity|downregulation of mu DNA polymerase activity|downregulation of nu DNA polymerase activity|downregulation of sequenase|downregulation of sigma DNA polymerase activity|downregulation of theta DNA polymerase activity|downregulation of zeta DNA polymerase activity|inhibition of DNA duplicase activity|inhibition of DNA nucleotidyltransferase (DNA-directed) activity|inhibition of DNA polymerase I|inhibition of DNA polymerase II|inhibition of DNA polymerase III|inhibition of DNA polymerase V activity|inhibition of DNA polymerase alpha|inhibition of DNA polymerase beta|inhibition of DNA polymerase gamma|inhibition of DNA replicase activity|inhibition of DNA-dependent DNA polymerase activity|inhibition of DNA-directed DNA polymerase activity|inhibition of Klenow fragment|inhibition of Taq DNA polymerase|inhibition of Taq Pol I|inhibition of Tca DNA polymerase|inhibition of alpha DNA polymerase activity|inhibition of beta DNA polymerase activity|inhibition of delta DNA polymerase activity|inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|inhibition of deoxyribonucleic acid duplicase activity|inhibition of deoxyribonucleic duplicase activity|inhibition of deoxyribonucleic polymerase I|inhibition of duplicase|inhibition of epsilon DNA polymerase activity|inhibition of eta DNA polymerase activity|inhibition of gamma DNA-directed DNA polymerase activity|inhibition of iota DNA polymerase activity|inhibition of kappa DNA polymerase activity|inhibition of lambda DNA polymerase activity|inhibition of mu DNA polymerase activity|inhibition of nu DNA polymerase activity|inhibition of sequenase|inhibition of sigma DNA polymerase activity|inhibition of theta DNA polymerase activity|inhibition of zeta DNA polymerase activity|negative regulation of DNA duplicase activity|negative regulation of DNA nucleotidyltransferase (DNA-directed) activity|negative regulation of DNA polymerase I|negative regulation of DNA polymerase II|negative regulation of DNA polymerase III|negative regulation of DNA polymerase V activity|negative regulation of DNA polymerase alpha|negative regulation of DNA polymerase beta|negative regulation of DNA polymerase gamma|negative regulation of DNA replicase activity|negative regulation of DNA-dependent DNA polymerase activity|negative regulation of Klenow fragment|negative regulation of Taq DNA polymerase|negative regulation of Taq Pol I|negative regulation of Tca DNA polymerase|negative regulation of alpha DNA polymerase activity|negative regulation of beta DNA polymerase activity|negative regulation of delta DNA polymerase activity|negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|negative regulation of deoxyribonucleic acid duplicase activity|negative regulation of deoxyribonucleic duplicase activity|negative regulation of deoxyribonucleic polymerase I|negative regulation of duplicase|negative regulation of epsilon DNA polymerase activity|negative regulation of eta DNA polymerase activity|negative regulation of gamma DNA-directed DNA polymerase activity|negative regulation of iota DNA polymerase activity|negative regulation of kappa DNA polymerase activity|negative regulation of lambda DNA polymerase activity|negative regulation of mu DNA polymerase activity|negative regulation of nu DNA polymerase activity|negative regulation of sequenase|negative regulation of sigma DNA polymerase activity|negative regulation of theta DNA polymerase activity|negative regulation of zeta DNA polymerase activity http://purl.obolibrary.org/obo/GO_1900263 gocheck_do_not_annotate GO:1900266 biolink:BiologicalProcess negative regulation of substance P receptor binding Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding. go.json down regulation of neurokinin-1 receptor binding|down regulation of substance P receptor binding|down regulation of substance P receptor ligand|down-regulation of neurokinin-1 receptor binding|down-regulation of substance P receptor binding|down-regulation of substance P receptor ligand|downregulation of neurokinin-1 receptor binding|downregulation of substance P receptor binding|downregulation of substance P receptor ligand|inhibition of neurokinin-1 receptor binding|inhibition of substance P receptor binding|inhibition of substance P receptor ligand|negative regulation of neurokinin-1 receptor binding|negative regulation of substance P receptor ligand http://purl.obolibrary.org/obo/GO_1900266 gocheck_do_not_annotate GO:0046199 biolink:BiologicalProcess cresol catabolic process The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. go.json cresol breakdown|cresol catabolism|cresol degradation http://purl.obolibrary.org/obo/GO_0046199 GO:1900265 biolink:BiologicalProcess regulation of substance P receptor binding Any process that modulates the frequency, rate or extent of substance P receptor binding. go.json regulation of neurokinin-1 receptor binding|regulation of substance P receptor ligand http://purl.obolibrary.org/obo/GO_1900265 gocheck_do_not_annotate GO:1900271 biolink:BiologicalProcess regulation of long-term synaptic potentiation Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. go.json regulation of LTP|regulation of long-term potentiation http://purl.obolibrary.org/obo/GO_1900271 GO:1900270 biolink:BiologicalProcess positive regulation of reverse transcription Any process that activates or increases the frequency, rate or extent of reverse transcription. go.json activation of reverse transcription|up regulation of reverse transcription|up-regulation of reverse transcription|upregulation of reverse transcription http://purl.obolibrary.org/obo/GO_1900270 GO:1900273 biolink:BiologicalProcess positive regulation of long-term synaptic potentiation Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. go.json activation of LTP|activation of long-term potentiation|activation of long-term synaptic potentiation|positive regulation of LTP|positive regulation of long-term potentiation|up regulation of LTP|up regulation of long-term potentiation|up regulation of long-term synaptic potentiation|up-regulation of LTP|up-regulation of long-term potentiation|up-regulation of long-term synaptic potentiation|upregulation of LTP|upregulation of long-term potentiation|upregulation of long-term synaptic potentiation http://purl.obolibrary.org/obo/GO_1900273 GO:1900272 biolink:BiologicalProcess negative regulation of long-term synaptic potentiation Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. go.json down regulation of LTP|down regulation of long-term potentiation|down regulation of long-term synaptic potentiation|down-regulation of LTP|down-regulation of long-term potentiation|down-regulation of long-term synaptic potentiation|downregulation of LTP|downregulation of long-term potentiation|downregulation of long-term synaptic potentiation|inhibition of LTP|inhibition of long-term potentiation|inhibition of long-term synaptic potentiation|negative regulation of LTP|negative regulation of long-term potentiation http://purl.obolibrary.org/obo/GO_1900272 GO:0071139 biolink:BiologicalProcess resolution of DNA recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged. go.json resolution of recombination intermediates http://purl.obolibrary.org/obo/GO_0071139 GO:0071138 biolink:CellularComponent alpha5-beta5-fibronectin-SFRP2 complex A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2. go.json ITGA5-ITGB5-FN-1-SFRP2 complex http://purl.obolibrary.org/obo/GO_0071138 GO:0071137 biolink:CellularComponent alphaV-beta3 integrin-CD98 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98. go.json ITGAV-ITGB3-SLC3A2 complex http://purl.obolibrary.org/obo/GO_0071137 GO:0071136 biolink:CellularComponent alpha7-beta1 integrin-laminin alpha-2 complex A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2. go.json ITGA7-ITGB1-LAMA2 complex http://purl.obolibrary.org/obo/GO_0071136 GO:0071135 biolink:CellularComponent alpha7-beta1 integrin-focal adhesion kinase complex A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase. go.json ITGA7-ITGB1-PTK2 complex http://purl.obolibrary.org/obo/GO_0071135 GO:0071134 biolink:CellularComponent alpha9-beta1 integrin-thrombospondin-1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1. go.json ITGA9-ITGB1-THBS1 complex http://purl.obolibrary.org/obo/GO_0071134 GO:0071133 biolink:CellularComponent alpha9-beta1 integrin-ADAM8 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8. go.json ITGA9-ITGB1-ADAM8 complex http://purl.obolibrary.org/obo/GO_0071133 GO:0071165 biolink:BiologicalProcess GINS complex assembly The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks. go.json http://purl.obolibrary.org/obo/GO_0071165 GO:0071164 biolink:MolecularActivity RNA trimethylguanosine synthase activity Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine. go.json cap hypermethylase activity|small nuclear RNA methyltransferase activity|snRNA methyltransferase activity http://purl.obolibrary.org/obo/GO_0071164 GO:0071163 biolink:BiologicalProcess DNA replication preinitiation complex assembly The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity. go.json DNA replication preinitiation complex formation|pre-IC complex assembly http://purl.obolibrary.org/obo/GO_0071163 GO:0071162 biolink:CellularComponent CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. go.json unwindosome http://purl.obolibrary.org/obo/GO_0071162 GO:0071161 biolink:MolecularActivity cyanophycin synthetase activity (L-arginine-adding) Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1. EC:6.3.2.30|RHEA:23888 go.json http://purl.obolibrary.org/obo/GO_0071161 GO:0071160 biolink:MolecularActivity cyanophycin synthetase activity (L-aspartate-adding) Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp. EC:6.3.2.29|RHEA:13277 go.json http://purl.obolibrary.org/obo/GO_0071160 GO:1900279 biolink:BiologicalProcess regulation of CD4-positive, alpha-beta T cell costimulation Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation. go.json regulation of CD4-positive, alpha beta T cell costimulation http://purl.obolibrary.org/obo/GO_1900279 GO:1900278 biolink:BiologicalProcess positive regulation of proteinase activated receptor activity Any process that activates or increases the frequency, rate or extent of proteinase activated receptor activity. go.json activation of proteinase activated receptor activity|up regulation of proteinase activated receptor activity|up-regulation of proteinase activated receptor activity|upregulation of proteinase activated receptor activity http://purl.obolibrary.org/obo/GO_1900278 gocheck_do_not_annotate GO:1900275 biolink:BiologicalProcess negative regulation of phospholipase C activity Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity. go.json down regulation of lecithinase C activity|down regulation of lipophosphodiesterase C|down regulation of phosphatidase C|down regulation of phospholipase C activity|down-regulation of lecithinase C activity|down-regulation of lipophosphodiesterase C|down-regulation of phosphatidase C|down-regulation of phospholipase C activity|downregulation of lecithinase C activity|downregulation of lipophosphodiesterase C|downregulation of phosphatidase C|downregulation of phospholipase C activity|inhibition of lecithinase C activity|inhibition of lipophosphodiesterase C|inhibition of phosphatidase C|inhibition of phospholipase C activity|negative regulation of lecithinase C activity|negative regulation of lipophosphodiesterase C|negative regulation of phosphatidase C http://purl.obolibrary.org/obo/GO_1900275 gocheck_do_not_annotate GO:1900274 biolink:BiologicalProcess regulation of phospholipase C activity Any process that modulates the frequency, rate or extent of phospholipase C activity. go.json regulation of lecithinase C activity|regulation of lipophosphodiesterase C|regulation of phosphatidase C http://purl.obolibrary.org/obo/GO_1900274 gocheck_do_not_annotate GO:1900277 biolink:BiologicalProcess negative regulation of proteinase activated receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity. go.json down regulation of proteinase activated receptor activity|down-regulation of proteinase activated receptor activity|downregulation of proteinase activated receptor activity|inhibition of proteinase activated receptor activity http://purl.obolibrary.org/obo/GO_1900277 gocheck_do_not_annotate GO:1900276 biolink:BiologicalProcess regulation of proteinase activated receptor activity Any process that modulates the frequency, rate or extent of proteinase activated receptor activity. go.json http://purl.obolibrary.org/obo/GO_1900276 gocheck_do_not_annotate GO:1900282 biolink:BiologicalProcess regulation of cellobiose catabolic process Any process that modulates the frequency, rate or extent of cellobiose catabolic process. go.json regulation of cellobiose catabolism http://purl.obolibrary.org/obo/GO_1900282 GO:1900281 biolink:BiologicalProcess positive regulation of CD4-positive, alpha-beta T cell costimulation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation. go.json activation of CD4-positive, alpha beta T cell costimulation|positive regulation of CD4-positive, alpha beta T cell costimulation|up regulation of CD4-positive, alpha beta T cell costimulation|up-regulation of CD4-positive, alpha beta T cell costimulation|upregulation of CD4-positive, alpha beta T cell costimulation http://purl.obolibrary.org/obo/GO_1900281 GO:1900284 biolink:BiologicalProcess positive regulation of cellobiose catabolic process Any process that activates or increases the frequency, rate or extent of cellobiose catabolic process. go.json activation of cellobiose catabolic process|activation of cellobiose catabolism|positive regulation of cellobiose catabolism|up regulation of cellobiose catabolic process|up regulation of cellobiose catabolism|up-regulation of cellobiose catabolic process|up-regulation of cellobiose catabolism|upregulation of cellobiose catabolic process|upregulation of cellobiose catabolism http://purl.obolibrary.org/obo/GO_1900284 GO:1900283 biolink:BiologicalProcess negative regulation of cellobiose catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose catabolic process. go.json down regulation of cellobiose catabolic process|down regulation of cellobiose catabolism|down-regulation of cellobiose catabolic process|down-regulation of cellobiose catabolism|downregulation of cellobiose catabolic process|downregulation of cellobiose catabolism|inhibition of cellobiose catabolic process|inhibition of cellobiose catabolism|negative regulation of cellobiose catabolism http://purl.obolibrary.org/obo/GO_1900283 GO:1900280 biolink:BiologicalProcess negative regulation of CD4-positive, alpha-beta T cell costimulation Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation. go.json down regulation of CD4-positive, alpha beta T cell costimulation|down-regulation of CD4-positive, alpha beta T cell costimulation|downregulation of CD4-positive, alpha beta T cell costimulation|inhibition of CD4-positive, alpha beta T cell costimulation|negative regulation of CD4-positive, alpha beta T cell costimulation http://purl.obolibrary.org/obo/GO_1900280 GO:0071169 biolink:BiologicalProcess establishment of protein localization to chromatin The directed movement of a protein to a part of a chromosome that is organized into chromatin. go.json establishment of protein localisation to chromatin http://purl.obolibrary.org/obo/GO_0071169 GO:0071168 biolink:BiologicalProcess protein localization to chromatin Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. go.json protein localisation to chromatin http://purl.obolibrary.org/obo/GO_0071168 GO:0071167 biolink:BiologicalProcess obsolete ribonucleoprotein complex import into nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus. go.json RNP import into nucleus|ribonucleoprotein complex import into cell nucleus|ribonucleoprotein complex nucleus import|ribonucleoprotein complex targeting to nucleus|ribonucleoprotein complex transport from cytoplasm to nucleus|ribonucleoprotein import into nucleus True http://purl.obolibrary.org/obo/GO_0071167 GO:0071166 biolink:BiologicalProcess ribonucleoprotein complex localization Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. go.json RNP localization|cellular ribonucleoprotein complex localization|establishment and maintenance of ribonucleoprotein complex localization|ribonucleoprotein complex localisation http://purl.obolibrary.org/obo/GO_0071166 GO:0071154 biolink:CellularComponent G-protein alpha(i)1-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein. go.json Ric-8A G(i) alpha-1 subunit complex|Ric-8A G(i) alpha-2 subunit complex http://purl.obolibrary.org/obo/GO_0071154 GO:0071153 biolink:CellularComponent G-protein alpha(o)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein. go.json Ric-8A G(o) alpha-1 subunit complex|Ric-8A G(o) alpha-2 subunit complex http://purl.obolibrary.org/obo/GO_0071153 GO:0071152 biolink:CellularComponent G-protein alpha(q)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein. go.json Ric-8A G(q) alpha subunit complex http://purl.obolibrary.org/obo/GO_0071152 GO:0071151 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071151 GO:0071150 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071150 GO:1900289 biolink:BiologicalProcess negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. go.json down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|down regulation of coenzyme F420-dependent nitroimidazole breakdown|down regulation of coenzyme F420-dependent nitroimidazole catabolism|down regulation of coenzyme F420-dependent nitroimidazole reduction|down regulation of coenzyme F420-dependent nitroreductase activity|down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|down-regulation of coenzyme F420-dependent nitroimidazole breakdown|down-regulation of coenzyme F420-dependent nitroimidazole catabolism|down-regulation of coenzyme F420-dependent nitroimidazole reduction|down-regulation of coenzyme F420-dependent nitroreductase activity|downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|downregulation of coenzyme F420-dependent nitroimidazole breakdown|downregulation of coenzyme F420-dependent nitroimidazole catabolism|downregulation of coenzyme F420-dependent nitroimidazole reduction|downregulation of coenzyme F420-dependent nitroreductase activity|inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|inhibition of coenzyme F420-dependent nitroimidazole breakdown|inhibition of coenzyme F420-dependent nitroimidazole catabolism|inhibition of coenzyme F420-dependent nitroimidazole reduction|inhibition of coenzyme F420-dependent nitroreductase activity|negative regulation of coenzyme F420-dependent nitroimidazole breakdown|negative regulation of coenzyme F420-dependent nitroimidazole catabolism|negative regulation of coenzyme F420-dependent nitroimidazole reduction|negative regulation of coenzyme F420-dependent nitroreductase activity http://purl.obolibrary.org/obo/GO_1900289 GO:1900286 biolink:BiologicalProcess negative regulation of cellotriose transport Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose transport. go.json down regulation of cellotriose transport|down-regulation of cellotriose transport|downregulation of cellotriose transport|inhibition of cellotriose transport http://purl.obolibrary.org/obo/GO_1900286 GO:1900285 biolink:BiologicalProcess regulation of cellotriose transport Any process that modulates the frequency, rate or extent of cellotriose transport. go.json http://purl.obolibrary.org/obo/GO_1900285 GO:1900288 biolink:BiologicalProcess regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. go.json regulation of coenzyme F420-dependent nitroimidazole breakdown|regulation of coenzyme F420-dependent nitroimidazole catabolism|regulation of coenzyme F420-dependent nitroimidazole reduction|regulation of coenzyme F420-dependent nitroreductase activity http://purl.obolibrary.org/obo/GO_1900288 GO:1900287 biolink:BiologicalProcess positive regulation of cellotriose transport Any process that activates or increases the frequency, rate or extent of cellotriose transport. go.json activation of cellotriose transport|up regulation of cellotriose transport|up-regulation of cellotriose transport|upregulation of cellotriose transport http://purl.obolibrary.org/obo/GO_1900287 GO:1900293 biolink:BiologicalProcess positive regulation of galactotriose transport Any process that activates or increases the frequency, rate or extent of galactotriose transport. go.json activation of galactotriose transport|up regulation of galactotriose transport|up-regulation of galactotriose transport|upregulation of galactotriose transport http://purl.obolibrary.org/obo/GO_1900293 GO:1900292 biolink:BiologicalProcess negative regulation of galactotriose transport Any process that stops, prevents or reduces the frequency, rate or extent of galactotriose transport. go.json down regulation of galactotriose transport|down-regulation of galactotriose transport|downregulation of galactotriose transport|inhibition of galactotriose transport http://purl.obolibrary.org/obo/GO_1900292 GO:1900295 biolink:BiologicalProcess negative regulation of heptasaccharide transport Any process that stops, prevents or reduces the frequency, rate or extent of heptasaccharide transport. go.json down regulation of heptasaccharide transport|down-regulation of heptasaccharide transport|downregulation of heptasaccharide transport|inhibition of heptasaccharide transport http://purl.obolibrary.org/obo/GO_1900295 GO:1900294 biolink:BiologicalProcess regulation of heptasaccharide transport Any process that modulates the frequency, rate or extent of heptasaccharide transport. go.json http://purl.obolibrary.org/obo/GO_1900294 GO:1900291 biolink:BiologicalProcess regulation of galactotriose transport Any process that modulates the frequency, rate or extent of galactotriose transport. go.json http://purl.obolibrary.org/obo/GO_1900291 GO:1900290 biolink:BiologicalProcess positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. go.json activation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|activation of coenzyme F420-dependent nitroimidazole breakdown|activation of coenzyme F420-dependent nitroimidazole catabolism|activation of coenzyme F420-dependent nitroimidazole reduction|activation of coenzyme F420-dependent nitroreductase activity|positive regulation of coenzyme F420-dependent nitroimidazole breakdown|positive regulation of coenzyme F420-dependent nitroimidazole catabolism|positive regulation of coenzyme F420-dependent nitroimidazole reduction|positive regulation of coenzyme F420-dependent nitroreductase activity|up regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|up regulation of coenzyme F420-dependent nitroimidazole breakdown|up regulation of coenzyme F420-dependent nitroimidazole catabolism|up regulation of coenzyme F420-dependent nitroimidazole reduction|up regulation of coenzyme F420-dependent nitroreductase activity|up-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|up-regulation of coenzyme F420-dependent nitroimidazole breakdown|up-regulation of coenzyme F420-dependent nitroimidazole catabolism|up-regulation of coenzyme F420-dependent nitroimidazole reduction|up-regulation of coenzyme F420-dependent nitroreductase activity|upregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process|upregulation of coenzyme F420-dependent nitroimidazole breakdown|upregulation of coenzyme F420-dependent nitroimidazole catabolism|upregulation of coenzyme F420-dependent nitroimidazole reduction|upregulation of coenzyme F420-dependent nitroreductase activity http://purl.obolibrary.org/obo/GO_1900290 GO:0071159 biolink:CellularComponent NF-kappaB complex A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. go.json http://purl.obolibrary.org/obo/GO_0071159 GO:0071158 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071158 GO:0071157 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071157 GO:0071156 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071156 GO:0071155 biolink:CellularComponent G-protein alpha(13)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein. go.json Ric-8A G alpha 13 subunit complex http://purl.obolibrary.org/obo/GO_0071155 GO:0071187 biolink:CellularComponent protocadherin-alpha-v4-protocadherin-gamma-b4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdhga1-Pcdhgb4 complex http://purl.obolibrary.org/obo/GO_0071187 GO:0071186 biolink:CellularComponent protocadherin-alpha-v4-protocadherin-gamma-b2 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdhga1-Pcdhgb2 complex http://purl.obolibrary.org/obo/GO_0071186 GO:0071185 biolink:CellularComponent protocadherin-alpha-v4-protocadherin-gamma-a3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdhga1-Pcdhga3 complex http://purl.obolibrary.org/obo/GO_0071185 GO:0071184 biolink:CellularComponent protocadherin-alpha-v4-protocadherin-gamma-a1 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdhga1-Pcdha4 complex http://purl.obolibrary.org/obo/GO_0071184 GO:0071183 biolink:CellularComponent protocadherin-alpha-protocadherin-gamma complex A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0071183 GO:0071182 biolink:CellularComponent MAML3-RBP-Jkappa-ICN4 complex A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML3-RBP-Jkappa-Notch4 complex http://purl.obolibrary.org/obo/GO_0071182 GO:0071181 biolink:CellularComponent MAML3-RBP-Jkappa-ICN3 complex A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML3-RBP-Jkappa-Notch3 complex http://purl.obolibrary.org/obo/GO_0071181 GO:0071180 biolink:CellularComponent MAML3-RBP-Jkappa-ICN2 complex A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML3-RBP-Jkappa-Notch2 complex http://purl.obolibrary.org/obo/GO_0071180 GO:1900297 biolink:BiologicalProcess regulation of hexasaccharide transport Any process that modulates the frequency, rate or extent of hexasaccharide transport. go.json http://purl.obolibrary.org/obo/GO_1900297 GO:1900296 biolink:BiologicalProcess positive regulation of heptasaccharide transport Any process that activates or increases the frequency, rate or extent of heptasaccharide transport. go.json activation of heptasaccharide transport|up regulation of heptasaccharide transport|up-regulation of heptasaccharide transport|upregulation of heptasaccharide transport http://purl.obolibrary.org/obo/GO_1900296 GO:1900299 biolink:BiologicalProcess positive regulation of hexasaccharide transport Any process that activates or increases the frequency, rate or extent of hexasaccharide transport. go.json activation of hexasaccharide transport|up regulation of hexasaccharide transport|up-regulation of hexasaccharide transport|upregulation of hexasaccharide transport http://purl.obolibrary.org/obo/GO_1900299 GO:1900298 biolink:BiologicalProcess negative regulation of hexasaccharide transport Any process that stops, prevents or reduces the frequency, rate or extent of hexasaccharide transport. go.json down regulation of hexasaccharide transport|down-regulation of hexasaccharide transport|downregulation of hexasaccharide transport|inhibition of hexasaccharide transport http://purl.obolibrary.org/obo/GO_1900298 GO:0071189 biolink:CellularComponent protocadherin-alpha-v7-protocadherin-gamma-a3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdha7-Pcdhga3 complex http://purl.obolibrary.org/obo/GO_0071189 GO:0071188 biolink:CellularComponent protocadherin-alpha-v7-protocadherin-gamma-a1 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane. go.json Pcdha7-Pcdhga1 complex http://purl.obolibrary.org/obo/GO_0071188 GO:0071176 biolink:CellularComponent MAML2-RBP-Jkappa-ICN2 complex A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML2-RBP-Jkappa-Notch2 complex http://purl.obolibrary.org/obo/GO_0071176 GO:0071175 biolink:CellularComponent MAML2-RBP-Jkappa-ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML2-RBP-Jkappa-Notch1 complex http://purl.obolibrary.org/obo/GO_0071175 GO:0071174 biolink:BiologicalProcess mitotic spindle checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form. go.json mitotic cell cycle spindle checkpoint|mitotic spindle checkpoint|signal transduction involved in mitotic cell cycle spindle checkpoint|signal transduction involved in mitotic spindle checkpoint|topo II checkpoint|topoisomerase II checkpoint http://purl.obolibrary.org/obo/GO_0071174 gocheck_do_not_manually_annotate GO:0071173 biolink:BiologicalProcess spindle assembly checkpoint signaling A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. go.json SAC|signal transduction involved in spindle assembly checkpoint|spindle assembly checkpoint http://purl.obolibrary.org/obo/GO_0071173 gocheck_do_not_manually_annotate GO:0071172 biolink:MolecularActivity dihydromonapterin reductase activity Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+. go.json http://purl.obolibrary.org/obo/GO_0071172 GO:0071171 biolink:BiologicalProcess site-specific DNA replication termination at RTS1 barrier A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching. go.json http://purl.obolibrary.org/obo/GO_0071171 GO:0071170 biolink:BiologicalProcess site-specific DNA replication termination A DNA replication termination process that takes place at a specific termination site. go.json http://purl.obolibrary.org/obo/GO_0071170 GO:0071179 biolink:CellularComponent MAML3-RBP-Jkappa-ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML3-RBP-Jkappa-Notch1 complex http://purl.obolibrary.org/obo/GO_0071179 GO:0071178 biolink:CellularComponent MAML2-RBP-Jkappa-ICN4 complex A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML2-RBP-Jkappa-Notch4 complex http://purl.obolibrary.org/obo/GO_0071178 GO:0071177 biolink:CellularComponent MAML2-RBP-Jkappa-ICN3 complex A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. go.json MAML2-RBP-Jkappa-Notch3 complex http://purl.obolibrary.org/obo/GO_0071177 GO:0061720 biolink:BiologicalProcess 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). go.json http://purl.obolibrary.org/obo/GO_0061720 GO:0061722 biolink:BiologicalProcess sulphoglycolysis The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate. go.json sulfoglycolysis http://purl.obolibrary.org/obo/GO_0061722 GO:0061721 biolink:BiologicalProcess 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-) The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-). MetaCyc:PWY-7446 go.json http://purl.obolibrary.org/obo/GO_0061721 GO:0061724 biolink:BiologicalProcess lipophagy The selective degradation of lipid droplets by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0061724 GO:0061723 biolink:BiologicalProcess glycophagy The selective degradation of glycogen by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0061723 GO:0061726 biolink:BiologicalProcess obsolete mitochondrion disassembly OBSOLETE. The disaggregation of a mitochondrion into its constituent components. go.json mitochondrion degradation True http://purl.obolibrary.org/obo/GO_0061726 GO:0061725 biolink:BiologicalProcess cytosolic lipolysis The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases. go.json http://purl.obolibrary.org/obo/GO_0061725 GO:0061728 biolink:BiologicalProcess GDP-mannose biosynthetic process from mannose The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose. go.json http://purl.obolibrary.org/obo/GO_0061728 GO:0061727 biolink:BiologicalProcess methylglyoxal catabolic process to lactate The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate. go.json http://purl.obolibrary.org/obo/GO_0061727 GO:0061729 biolink:BiologicalProcess GDP-mannose biosynthetic process from fructose-6-phosphate The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate. Reactome:R-HSA-446205 go.json http://purl.obolibrary.org/obo/GO_0061729 GO:0061711 biolink:MolecularActivity N(6)-L-threonylcarbamoyladenine synthase activity Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA. EC:2.3.1.234|MetaCyc:RXN-14570|RHEA:37059|Reactome:R-HSA-6784494 go.json http://purl.obolibrary.org/obo/GO_0061711 GO:0061710 biolink:MolecularActivity L-threonylcarbamoyladenylate synthase Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. EC:2.7.7.87|MetaCyc:RXN-14569|RHEA:36407 go.json http://purl.obolibrary.org/obo/GO_0061710 GO:0061713 biolink:BiologicalProcess anterior neural tube closure The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline. go.json http://purl.obolibrary.org/obo/GO_0061713 GO:0061712 biolink:MolecularActivity tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine. EC:2.8.4.5|MetaCyc:RXN-14531|RHEA:37075 go.json http://purl.obolibrary.org/obo/GO_0061712 GO:0061715 biolink:BiologicalProcess obsolete miRNA 2'-O-methylation OBSOLETE. The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule. go.json True http://purl.obolibrary.org/obo/GO_0061715 GO:0061714 biolink:MolecularActivity folic acid receptor activity Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis. go.json folate receptor activity http://purl.obolibrary.org/obo/GO_0061714 GO:0061717 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061717 GO:0061716 biolink:BiologicalProcess miRNA export from nucleus The directed movement of a processed miRNA from the nucleus to the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0061716 GO:0061719 biolink:BiologicalProcess glucose catabolic process to pyruvate utilizing ADP The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions. MetaCyc:P341-PWY go.json http://purl.obolibrary.org/obo/GO_0061719 GO:0061718 biolink:BiologicalProcess glucose catabolic process to pyruvate The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate. go.json glucose catabolism to pyruvate http://purl.obolibrary.org/obo/GO_0061718 GO:0046107 biolink:BiologicalProcess uracil biosynthetic process The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. go.json uracil anabolism|uracil biosynthesis|uracil formation|uracil synthesis http://purl.obolibrary.org/obo/GO_0046107 GO:0046106 biolink:BiologicalProcess thymine biosynthetic process The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. go.json thymine anabolism|thymine biosynthesis|thymine formation|thymine synthesis http://purl.obolibrary.org/obo/GO_0046106 GO:0046105 biolink:BiologicalProcess thymidine biosynthetic process The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. go.json deoxyribosylthymine biosynthesis|deoxyribosylthymine biosynthetic process|thymidine anabolism|thymidine biosynthesis|thymidine formation|thymidine synthesis http://purl.obolibrary.org/obo/GO_0046105 GO:0046104 biolink:BiologicalProcess thymidine metabolic process The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. go.json deoxyribosylthymine metabolic process|deoxyribosylthymine metabolism|thymidine metabolism http://purl.obolibrary.org/obo/GO_0046104 GO:0046103 biolink:BiologicalProcess inosine biosynthetic process The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. go.json inosine anabolism|inosine biosynthesis|inosine formation|inosine synthesis http://purl.obolibrary.org/obo/GO_0046103 GO:0046102 biolink:BiologicalProcess inosine metabolic process The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. go.json inosine metabolism http://purl.obolibrary.org/obo/GO_0046102 GO:0046101 biolink:BiologicalProcess hypoxanthine biosynthetic process The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. go.json hypoxanthine anabolism|hypoxanthine biosynthesis|hypoxanthine formation|hypoxanthine synthesis http://purl.obolibrary.org/obo/GO_0046101 GO:0046100 biolink:BiologicalProcess hypoxanthine metabolic process The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. go.json hypoxanthine metabolism http://purl.obolibrary.org/obo/GO_0046100 GO:0061740 biolink:BiologicalProcess protein targeting to lysosome involved in chaperone-mediated autophagy The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor. go.json http://purl.obolibrary.org/obo/GO_0061740 GO:0061742 biolink:CellularComponent chaperone-mediated autophagy translocation complex A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy. go.json CMA receptor complex|CMA translocation complex|chaperone-mediated autophagy receptor complex http://purl.obolibrary.org/obo/GO_0061742 GO:0061741 biolink:BiologicalProcess obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy OBSOLETE. The chaperone-mediated protein transport process in which a protein that is bound to a chaperone and a lysosomal receptor is unfolded and transported into the lysosome as part of chaperone-mediated autophagy. go.json True http://purl.obolibrary.org/obo/GO_0061741 GO:0061744 biolink:BiologicalProcess motor behavior The specific neuromuscular movement of a single organism in response to external or internal stimuli. go.json http://purl.obolibrary.org/obo/GO_0061744 GO:0061743 biolink:BiologicalProcess motor learning Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience. go.json http://purl.obolibrary.org/obo/GO_0061743 GO:0046109 biolink:BiologicalProcess uridine biosynthetic process The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. go.json uridine anabolism|uridine biosynthesis|uridine formation|uridine synthesis http://purl.obolibrary.org/obo/GO_0046109 GO:0061746 biolink:MolecularActivity obsolete single-stranded DNA-dependent GTPase activity OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. go.json True http://purl.obolibrary.org/obo/GO_0061746 GO:0061745 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061745 GO:0046108 biolink:BiologicalProcess uridine metabolic process The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. go.json uridine metabolism http://purl.obolibrary.org/obo/GO_0046108 GO:0061748 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061748 GO:0061747 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061747 GO:0061749 biolink:MolecularActivity forked DNA-dependent helicase activity Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0061749 GO:0046110 biolink:BiologicalProcess xanthine metabolic process The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. go.json xanthine metabolism http://purl.obolibrary.org/obo/GO_0046110 GO:0046118 biolink:BiologicalProcess 7-methylguanosine biosynthetic process The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. go.json 7-methylguanosine anabolism|7-methylguanosine biosynthesis|7-methylguanosine formation|7-methylguanosine synthesis http://purl.obolibrary.org/obo/GO_0046118 GO:0046117 biolink:BiologicalProcess queuosine catabolic process The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. go.json queuosine breakdown|queuosine catabolism|queuosine degradation http://purl.obolibrary.org/obo/GO_0046117 GO:0046116 biolink:BiologicalProcess queuosine metabolic process The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. go.json queuosine metabolism http://purl.obolibrary.org/obo/GO_0046116 GO:0046115 biolink:BiologicalProcess guanosine catabolic process The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution. go.json guanosine breakdown|guanosine catabolism|guanosine degradation|guanosine phosphorolysis http://purl.obolibrary.org/obo/GO_0046115 GO:0046114 biolink:BiologicalProcess guanosine biosynthetic process The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution. go.json guanosine anabolism|guanosine biosynthesis|guanosine formation|guanosine synthesis http://purl.obolibrary.org/obo/GO_0046114 GO:0046113 biolink:BiologicalProcess nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. go.json nucleobase breakdown|nucleobase catabolism|nucleobase degradation http://purl.obolibrary.org/obo/GO_0046113 GO:0046112 biolink:BiologicalProcess nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. go.json nucleobase anabolism|nucleobase biosynthesis|nucleobase formation|nucleobase synthesis http://purl.obolibrary.org/obo/GO_0046112 GO:0046111 biolink:BiologicalProcess xanthine biosynthetic process The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. go.json xanthine anabolism|xanthine biosynthesis|xanthine formation|xanthine synthesis http://purl.obolibrary.org/obo/GO_0046111 GO:0061731 biolink:MolecularActivity ribonucleoside-diphosphate reductase activity Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. go.json RNR|adenosylcobalamin-dependent ribonucleotide reductase activity|aerobic non-heme iron-dependent ribonucleotide reductase activity|anaerobic iron-sulfur-dependent ribonucleotide reductase activity|class I ribonucleotide reductase activity|class II ribonucleoside-diphosphate reductase activity|class II ribonucleotide reductase activity|class III ribonucleotide reductase activity|nucleoside diphosphate reductase activity|purine/pyrimidine nucleoside diphosphate reduction|ribonucleoside 5'-diphosphate reductase activity|ribonucleotide diphosphate reductase activity|ribonucleotide reductase activity http://purl.obolibrary.org/obo/GO_0061731 GO:0061730 biolink:MolecularActivity C-rich strand telomeric DNA binding Binding to C-rich, single-stranded, telomere-associated DNA. go.json http://purl.obolibrary.org/obo/GO_0061730 GO:0061733 biolink:MolecularActivity peptide-lysine-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. RHEA:45948|Reactome:R-HSA-6811508|Reactome:R-HSA-8951966|Reactome:R-HSA-9617758|Reactome:R-HSA-9620515|Reactome:R-HSA-9626945|Reactome:R-HSA-9701531|Reactome:R-HSA-9756494 go.json peptide-lysine-N-acetylase activity|protein acetylase activity|protein acetyltransferase activity|protein-lysine-N-acetylase activity http://purl.obolibrary.org/obo/GO_0061733 GO:0061732 biolink:BiologicalProcess obsolete mitochondrial acetyl-CoA biosynthetic process from pyruvate OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA. go.json True http://purl.obolibrary.org/obo/GO_0061732 GO:0061735 biolink:BiologicalProcess DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a DNM1L-family molecule. go.json dynamin-like protein-mediated stimulation of mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_0061735 GO:0046119 biolink:BiologicalProcess 7-methylguanosine catabolic process The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. go.json 7-methylguanosine breakdown|7-methylguanosine catabolism|7-methylguanosine degradation http://purl.obolibrary.org/obo/GO_0046119 GO:0061734 biolink:BiologicalProcess parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule. go.json PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization|Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization http://purl.obolibrary.org/obo/GO_0061734 GO:0061737 biolink:BiologicalProcess leukotriene signaling pathway A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json http://purl.obolibrary.org/obo/GO_0061737 GO:0061736 biolink:BiologicalProcess engulfment of target by autophagosome The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy. go.json http://purl.obolibrary.org/obo/GO_0061736 GO:0061739 biolink:BiologicalProcess protein lipidation involved in autophagosome assembly The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly. go.json http://purl.obolibrary.org/obo/GO_0061739 gocheck_do_not_annotate GO:0061738 biolink:BiologicalProcess late endosomal microautophagy The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment. go.json http://purl.obolibrary.org/obo/GO_0061738 GO:0046121 biolink:BiologicalProcess deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json deoxyribonucleoside breakdown|deoxyribonucleoside catabolism|deoxyribonucleoside degradation http://purl.obolibrary.org/obo/GO_0046121 GO:0046120 biolink:BiologicalProcess deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json deoxyribonucleoside anabolism|deoxyribonucleoside biosynthesis|deoxyribonucleoside formation|deoxyribonucleoside synthesis http://purl.obolibrary.org/obo/GO_0046120 GO:0046129 biolink:BiologicalProcess purine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json purine ribonucleoside anabolism|purine ribonucleoside biosynthesis|purine ribonucleoside formation|purine ribonucleoside synthesis http://purl.obolibrary.org/obo/GO_0046129 GO:0046128 biolink:BiologicalProcess purine ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json purine ribonucleoside metabolism http://purl.obolibrary.org/obo/GO_0046128 GO:0046127 biolink:BiologicalProcess pyrimidine deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json pyrimidine deoxyribonucleoside breakdown|pyrimidine deoxyribonucleoside catabolism|pyrimidine deoxyribonucleoside degradation http://purl.obolibrary.org/obo/GO_0046127 GO:0046126 biolink:BiologicalProcess pyrimidine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json pyrimidine deoxyribonucleoside anabolism|pyrimidine deoxyribonucleoside biosynthesis|pyrimidine deoxyribonucleoside formation|pyrimidine deoxyribonucleoside synthesis http://purl.obolibrary.org/obo/GO_0046126 GO:0046125 biolink:BiologicalProcess pyrimidine deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json pyrimidine deoxyribonucleoside metabolism http://purl.obolibrary.org/obo/GO_0046125 GO:0046124 biolink:BiologicalProcess purine deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json purine deoxyribonucleoside breakdown|purine deoxyribonucleoside catabolism|purine deoxyribonucleoside degradation http://purl.obolibrary.org/obo/GO_0046124 GO:0046123 biolink:BiologicalProcess purine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json purine deoxyribonucleoside anabolism|purine deoxyribonucleoside biosynthesis|purine deoxyribonucleoside formation|purine deoxyribonucleoside synthesis http://purl.obolibrary.org/obo/GO_0046123 GO:0061760 biolink:BiologicalProcess antifungal innate immune response An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. go.json http://purl.obolibrary.org/obo/GO_0061760 GO:0046122 biolink:BiologicalProcess purine deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). go.json purine deoxyribonucleoside metabolism http://purl.obolibrary.org/obo/GO_0046122 GO:0061762 biolink:BiologicalProcess CAMKK-AMPK signaling cascade The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. go.json stress-activated AMP-activated protein kinase signaling cascade http://purl.obolibrary.org/obo/GO_0061762 GO:0061761 biolink:MolecularActivity alpha-latrotoxin receptor binding Binding to an alpha-latrotoxin receptor. go.json lasso receptor binding|latrophilin binding http://purl.obolibrary.org/obo/GO_0061761 GO:0061764 biolink:BiologicalProcess late endosome to lysosome transport via multivesicular body sorting pathway The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. go.json http://purl.obolibrary.org/obo/GO_0061764 GO:0061763 biolink:BiologicalProcess multivesicular body-lysosome fusion The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. go.json MVB-lysosome fusion|fusion of MVB to lysosome|fusion of multivesicular body to lysosome http://purl.obolibrary.org/obo/GO_0061763 GO:0061766 biolink:BiologicalProcess positive regulation of lung blood pressure The process that increases the force with which blood travels through the lungs. go.json positive regulation of pulmonary blood pressure http://purl.obolibrary.org/obo/GO_0061766 GO:0061765 biolink:BiologicalProcess perturbation by virus of host non-canonical NF-kappaB signal transduction A process in which a symbiont alters or subverts a non-canonical NF-kappaB signaling cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json modulation by virus of host NIK/NF-kappaB cascade|modulation by virus of host NIK/NF-kappaB signaling|perturbation by virus of host NIK/NF-kappaB cascade http://purl.obolibrary.org/obo/GO_0061765 GO:0061768 biolink:MolecularActivity magnesium:sodium antiporter activity Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in). go.json http://purl.obolibrary.org/obo/GO_0061768 GO:0061767 biolink:BiologicalProcess negative regulation of lung blood pressure The process that decreases the force with which blood travels through the lungs. go.json negative regulation of pulmonary blood pressure http://purl.obolibrary.org/obo/GO_0061767 GO:0061769 biolink:MolecularActivity ribosylnicotinate kinase activity Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide. Reactome:R-HSA-8869606|Reactome:R-HSA-8869607 go.json http://purl.obolibrary.org/obo/GO_0061769 GO:0046132 biolink:BiologicalProcess pyrimidine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json pyrimidine ribonucleoside anabolism|pyrimidine ribonucleoside biosynthesis|pyrimidine ribonucleoside formation|pyrimidine ribonucleoside synthesis http://purl.obolibrary.org/obo/GO_0046132 GO:1900209 biolink:BiologicalProcess negative regulation of cardiolipin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process. go.json down regulation of cardiolipin metabolic process|down regulation of cardiolipin metabolism|down regulation of diphosphatidylglycerol metabolic process|down regulation of diphosphatidylglycerol metabolism|down-regulation of cardiolipin metabolic process|down-regulation of cardiolipin metabolism|down-regulation of diphosphatidylglycerol metabolic process|down-regulation of diphosphatidylglycerol metabolism|downregulation of cardiolipin metabolic process|downregulation of cardiolipin metabolism|downregulation of diphosphatidylglycerol metabolic process|downregulation of diphosphatidylglycerol metabolism|inhibition of cardiolipin metabolic process|inhibition of cardiolipin metabolism|inhibition of diphosphatidylglycerol metabolic process|inhibition of diphosphatidylglycerol metabolism|negative regulation of cardiolipin metabolism|negative regulation of diphosphatidylglycerol metabolic process|negative regulation of diphosphatidylglycerol metabolism http://purl.obolibrary.org/obo/GO_1900209 GO:0046131 biolink:BiologicalProcess pyrimidine ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json pyrimidine ribonucleoside metabolism http://purl.obolibrary.org/obo/GO_0046131 GO:0046130 biolink:BiologicalProcess purine ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json purine ribonucleoside breakdown|purine ribonucleoside catabolism|purine ribonucleoside degradation http://purl.obolibrary.org/obo/GO_0046130 GO:1900206 biolink:BiologicalProcess regulation of pronephric nephron tubule development Any process that modulates the frequency, rate or extent of pronephric nephron tubule development. go.json http://purl.obolibrary.org/obo/GO_1900206 GO:1900205 biolink:BiologicalProcess apoptotic process involved in metanephric nephron tubule development Any apoptotic process that is involved in metanephric nephron tubule development. go.json apoptosis of metanephric nephron tubule development|apoptotic cell death of metanephric nephron tubule development|apoptotic process of metanephric nephron tubule development|apoptotic program of metanephric nephron tubule development|apoptotic programmed cell death of metanephric nephron tubule development|programmed cell death by apoptosis of metanephric nephron tubule development|signaling (initiator) caspase activity of metanephric nephron tubule development|type I programmed cell death of metanephric nephron tubule development http://purl.obolibrary.org/obo/GO_1900205 GO:1900208 biolink:BiologicalProcess regulation of cardiolipin metabolic process Any process that modulates the frequency, rate or extent of cardiolipin metabolic process. go.json regulation of cardiolipin metabolism|regulation of diphosphatidylglycerol metabolic process|regulation of diphosphatidylglycerol metabolism http://purl.obolibrary.org/obo/GO_1900208 GO:1900207 biolink:BiologicalProcess negative regulation of pronephric nephron tubule development Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development. go.json down regulation of pronephric nephron tubule development|down-regulation of pronephric nephron tubule development|downregulation of pronephric nephron tubule development|inhibition of pronephric nephron tubule development http://purl.obolibrary.org/obo/GO_1900207 GO:1900202 biolink:BiologicalProcess obsolete negative regulation of spread of virus in host, cell to cell OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of spread of virus in host, cell to cell. go.json down regulation of cell to cell spread of virus within host|down regulation of spread of virus in host, cell to cell|down regulation of spread of virus within host, cell to cell|down regulation of viral spread within host, cell to cell|down-regulation of cell to cell spread of virus within host|down-regulation of spread of virus in host, cell to cell|down-regulation of spread of virus within host, cell to cell|down-regulation of viral spread within host, cell to cell|downregulation of cell to cell spread of virus within host|downregulation of spread of virus in host, cell to cell|downregulation of spread of virus within host, cell to cell|downregulation of viral spread within host, cell to cell|inhibition of cell to cell spread of virus within host|inhibition of spread of virus in host, cell to cell|inhibition of spread of virus within host, cell to cell|inhibition of viral spread within host, cell to cell|negative regulation of cell to cell spread of virus within host|negative regulation of spread of virus in host, cell to cell|negative regulation of spread of virus within host, cell to cell|negative regulation of viral spread within host, cell to cell True http://purl.obolibrary.org/obo/GO_1900202 GO:0046139 biolink:BiologicalProcess obsolete coenzyme and prosthetic group catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups. go.json coenzyme and prosthetic group breakdown|coenzyme and prosthetic group catabolic process|coenzyme and prosthetic group catabolism|coenzyme and prosthetic group degradation True http://purl.obolibrary.org/obo/GO_0046139 GO:1900201 biolink:BiologicalProcess obsolete regulation of spread of virus in host, cell to cell OBSOLETE. Any process that modulates the frequency, rate or extent of spread of virus in host, cell to cell. go.json regulation of cell to cell spread of virus within host|regulation of spread of virus in host, cell to cell|regulation of spread of virus within host, cell to cell|regulation of viral spread within host, cell to cell True http://purl.obolibrary.org/obo/GO_1900201 GO:1900204 biolink:BiologicalProcess apoptotic process involved in metanephric collecting duct development Any apoptotic process that is involved in metanephric collecting duct development. go.json apoptosis of metanephric collecting duct development|apoptotic cell death of metanephric collecting duct development|apoptotic process of metanephric collecting duct development|apoptotic program of metanephric collecting duct development|apoptotic programmed cell death of metanephric collecting duct development|programmed cell death by apoptosis of metanephric collecting duct development|signaling (initiator) caspase activity of metanephric collecting duct development|type I programmed cell death of metanephric collecting duct development http://purl.obolibrary.org/obo/GO_1900204 GO:0046138 biolink:BiologicalProcess obsolete coenzyme and prosthetic group biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups. go.json coenzyme and prosthetic group anabolism|coenzyme and prosthetic group biosynthesis|coenzyme and prosthetic group biosynthetic process|coenzyme and prosthetic group formation|coenzyme and prosthetic group synthesis True http://purl.obolibrary.org/obo/GO_0046138 GO:0046137 biolink:BiologicalProcess negative regulation of vitamin metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json down regulation of vitamin metabolic process|down-regulation of vitamin metabolic process|downregulation of vitamin metabolic process|inhibition of vitamin metabolic process|negative regulation of vitamin metabolism http://purl.obolibrary.org/obo/GO_0046137 GO:1900203 biolink:BiologicalProcess obsolete positive regulation of spread of virus in host, cell to cell OBSOLETE. Any process that activates or increases the frequency, rate or extent of spread of virus in host, cell to cell. go.json activation of cell to cell spread of virus within host|activation of spread of virus in host, cell to cell|activation of spread of virus within host, cell to cell|activation of viral spread within host, cell to cell|positive regulation of cell to cell spread of virus within host|positive regulation of spread of virus in host, cell to cell|positive regulation of spread of virus within host, cell to cell|positive regulation of viral spread within host, cell to cell|up regulation of cell to cell spread of virus within host|up regulation of spread of virus in host, cell to cell|up regulation of spread of virus within host, cell to cell|up regulation of viral spread within host, cell to cell|up-regulation of cell to cell spread of virus within host|up-regulation of spread of virus in host, cell to cell|up-regulation of spread of virus within host, cell to cell|up-regulation of viral spread within host, cell to cell|upregulation of cell to cell spread of virus within host|upregulation of spread of virus in host, cell to cell|upregulation of spread of virus within host, cell to cell|upregulation of viral spread within host, cell to cell True http://purl.obolibrary.org/obo/GO_1900203 GO:0046136 biolink:BiologicalProcess positive regulation of vitamin metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. go.json activation of vitamin metabolic process|positive regulation of vitamin metabolism|stimulation of vitamin metabolic process|up regulation of vitamin metabolic process|up-regulation of vitamin metabolic process|upregulation of vitamin metabolic process http://purl.obolibrary.org/obo/GO_0046136 GO:0046135 biolink:BiologicalProcess pyrimidine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json pyrimidine nucleoside breakdown|pyrimidine nucleoside catabolism|pyrimidine nucleoside degradation http://purl.obolibrary.org/obo/GO_0046135 GO:0046134 biolink:BiologicalProcess pyrimidine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). go.json pyrimidine nucleoside anabolism|pyrimidine nucleoside biosynthesis|pyrimidine nucleoside formation|pyrimidine nucleoside synthesis http://purl.obolibrary.org/obo/GO_0046134 GO:1900200 biolink:BiologicalProcess mesenchymal cell apoptotic process involved in metanephros development Any mesenchymal cell apoptotic process that is involved in metanephros development. go.json mesenchymal cell apoptosis involved in metanephros development http://purl.obolibrary.org/obo/GO_1900200 GO:0046133 biolink:BiologicalProcess pyrimidine ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. go.json pyrimidine ribonucleoside breakdown|pyrimidine ribonucleoside catabolism|pyrimidine ribonucleoside degradation http://purl.obolibrary.org/obo/GO_0046133 GO:0061751 biolink:MolecularActivity neutral sphingomyelin phosphodiesterase activity Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment. go.json neutral SMase|neutral sphingomyelinase http://purl.obolibrary.org/obo/GO_0061751 GO:0061750 biolink:MolecularActivity acid sphingomyelin phosphodiesterase activity Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment. go.json acid SMase|acid sphingomyelinase http://purl.obolibrary.org/obo/GO_0061750 GO:0061753 biolink:BiologicalProcess substrate localization to autophagosome The localization process by which an autophagic substrate is delivered to a forming autophagosome. go.json substrate sequestration to autophagosome|substrate sequestration to phagophore http://purl.obolibrary.org/obo/GO_0061753 GO:0061752 biolink:MolecularActivity telomeric repeat-containing RNA binding Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats. go.json TERRA binding http://purl.obolibrary.org/obo/GO_0061752 GO:0061755 biolink:BiologicalProcess positive regulation of circulating fibrinogen levels Any process that increases the quantity of fibrinogen circulating in the bloodstream. go.json http://purl.obolibrary.org/obo/GO_0061755 GO:0061754 biolink:BiologicalProcess negative regulation of circulating fibrinogen levels Any process that reduces the quantity of fibrinogen circulating in the bloodstream. go.json http://purl.obolibrary.org/obo/GO_0061754 GO:0061757 biolink:BiologicalProcess leukocyte adhesion to arterial endothelial cell The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0061757 GO:0061756 biolink:BiologicalProcess leukocyte adhesion to vascular endothelial cell The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0061756 GO:0061759 biolink:MolecularActivity alpha-ketoglutarate reductase activity Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor. RHEA:21254 go.json 2-hydroxyglutarate dehydrogenase activity, reverse reaction|2-ketoglutarate reductase activity|2-oxoglutarate reductase activity|D-2HG reductase activity http://purl.obolibrary.org/obo/GO_0061759 GO:0061758 biolink:MolecularActivity 2-hydroxyglutarate dehydrogenase activity, forward reaction Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor. RHEA:21253 go.json alpha-ketoglutarate reductase activity, reverse reaction http://purl.obolibrary.org/obo/GO_0061758 GO:0046143 biolink:BiologicalProcess obsolete positive regulation of coenzyme and prosthetic group metabolic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups. go.json positive regulation of coenzyme and prosthetic group metabolic process True http://purl.obolibrary.org/obo/GO_0046143 GO:0046142 biolink:BiologicalProcess obsolete negative regulation of coenzyme and prosthetic group metabolic process OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups. go.json negative regulation of coenzyme and prosthetic group metabolic process True http://purl.obolibrary.org/obo/GO_0046142 GO:0046141 biolink:BiologicalProcess corrin catabolic process The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. go.json corrin breakdown|corrin catabolism|corrin degradation http://purl.obolibrary.org/obo/GO_0046141 GO:0046140 biolink:BiologicalProcess corrin biosynthetic process The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. go.json corrin anabolism|corrin biosynthesis|corrin formation|corrin synthesis http://purl.obolibrary.org/obo/GO_0046140 GO:1900217 biolink:BiologicalProcess regulation of apoptotic process involved in metanephric nephron tubule development Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development. go.json regulation of apoptosis of metanephric nephron tubule development|regulation of apoptotic cell death of metanephric nephron tubule development|regulation of apoptotic process of metanephric nephron tubule development|regulation of apoptotic program of metanephric nephron tubule development|regulation of apoptotic programmed cell death of metanephric nephron tubule development|regulation of programmed cell death by apoptosis of metanephric nephron tubule development|regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|regulation of type I programmed cell death of metanephric nephron tubule development http://purl.obolibrary.org/obo/GO_1900217 GO:1900216 biolink:BiologicalProcess positive regulation of apoptotic process involved in metanephric collecting duct development Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development. go.json activation of apoptosis of metanephric collecting duct development|activation of apoptotic cell death of metanephric collecting duct development|activation of apoptotic process involved in metanephric collecting duct development|activation of apoptotic process of metanephric collecting duct development|activation of apoptotic program of metanephric collecting duct development|activation of apoptotic programmed cell death of metanephric collecting duct development|activation of programmed cell death by apoptosis of metanephric collecting duct development|activation of signaling (initiator) caspase activity of metanephric collecting duct development|activation of type I programmed cell death of metanephric collecting duct development|positive regulation of apoptosis of metanephric collecting duct development|positive regulation of apoptotic cell death of metanephric collecting duct development|positive regulation of apoptotic process of metanephric collecting duct development|positive regulation of apoptotic program of metanephric collecting duct development|positive regulation of apoptotic programmed cell death of metanephric collecting duct development|positive regulation of programmed cell death by apoptosis of metanephric collecting duct development|positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development|positive regulation of type I programmed cell death of metanephric collecting duct development|up regulation of apoptosis of metanephric collecting duct development|up regulation of apoptotic cell death of metanephric collecting duct development|up regulation of apoptotic process involved in metanephric collecting duct development|up regulation of apoptotic process of metanephric collecting duct development|up regulation of apoptotic program of metanephric collecting duct development|up regulation of apoptotic programmed cell death of metanephric collecting duct development|up regulation of programmed cell death by apoptosis of metanephric collecting duct development|up regulation of signaling (initiator) caspase activity of metanephric collecting duct development|up regulation of type I programmed cell death of metanephric collecting duct development|up-regulation of apoptosis of metanephric collecting duct development|up-regulation of apoptotic cell death of metanephric collecting duct development|up-regulation of apoptotic process involved in metanephric collecting duct development|up-regulation of apoptotic process of metanephric collecting duct development|up-regulation of apoptotic program of metanephric collecting duct development|up-regulation of apoptotic programmed cell death of metanephric collecting duct development|up-regulation of programmed cell death by apoptosis of metanephric collecting duct development|up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development|up-regulation of type I programmed cell death of metanephric collecting duct development|upregulation of apoptosis of metanephric collecting duct development|upregulation of apoptotic cell death of metanephric collecting duct development|upregulation of apoptotic process involved in metanephric collecting duct development|upregulation of apoptotic process of metanephric collecting duct development|upregulation of apoptotic program of metanephric collecting duct development|upregulation of apoptotic programmed cell death of metanephric collecting duct development|upregulation of programmed cell death by apoptosis of metanephric collecting duct development|upregulation of signaling (initiator) caspase activity of metanephric collecting duct development|upregulation of type I programmed cell death of metanephric collecting duct development http://purl.obolibrary.org/obo/GO_1900216 GO:1900219 biolink:BiologicalProcess positive regulation of apoptotic process involved in metanephric nephron tubule development Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development. go.json activation of apoptosis of metanephric nephron tubule development|activation of apoptotic cell death of metanephric nephron tubule development|activation of apoptotic process involved in metanephric nephron tubule development|activation of apoptotic process of metanephric nephron tubule development|activation of apoptotic program of metanephric nephron tubule development|activation of apoptotic programmed cell death of metanephric nephron tubule development|activation of programmed cell death by apoptosis of metanephric nephron tubule development|activation of signaling (initiator) caspase activity of metanephric nephron tubule development|activation of type I programmed cell death of metanephric nephron tubule development|positive regulation of apoptosis of metanephric nephron tubule development|positive regulation of apoptotic cell death of metanephric nephron tubule development|positive regulation of apoptotic process of metanephric nephron tubule development|positive regulation of apoptotic program of metanephric nephron tubule development|positive regulation of apoptotic programmed cell death of metanephric nephron tubule development|positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development|positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|positive regulation of type I programmed cell death of metanephric nephron tubule development|up regulation of apoptosis of metanephric nephron tubule development|up regulation of apoptotic cell death of metanephric nephron tubule development|up regulation of apoptotic process involved in metanephric nephron tubule development|up regulation of apoptotic process of metanephric nephron tubule development|up regulation of apoptotic program of metanephric nephron tubule development|up regulation of apoptotic programmed cell death of metanephric nephron tubule development|up regulation of programmed cell death by apoptosis of metanephric nephron tubule development|up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|up regulation of type I programmed cell death of metanephric nephron tubule development|up-regulation of apoptosis of metanephric nephron tubule development|up-regulation of apoptotic cell death of metanephric nephron tubule development|up-regulation of apoptotic process involved in metanephric nephron tubule development|up-regulation of apoptotic process of metanephric nephron tubule development|up-regulation of apoptotic program of metanephric nephron tubule development|up-regulation of apoptotic programmed cell death of metanephric nephron tubule development|up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development|up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|up-regulation of type I programmed cell death of metanephric nephron tubule development|upregulation of apoptosis of metanephric nephron tubule development|upregulation of apoptotic cell death of metanephric nephron tubule development|upregulation of apoptotic process involved in metanephric nephron tubule development|upregulation of apoptotic process of metanephric nephron tubule development|upregulation of apoptotic program of metanephric nephron tubule development|upregulation of apoptotic programmed cell death of metanephric nephron tubule development|upregulation of programmed cell death by apoptosis of metanephric nephron tubule development|upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development|upregulation of type I programmed cell death of metanephric nephron tubule development http://purl.obolibrary.org/obo/GO_1900219 GO:1900218 biolink:BiologicalProcess negative regulation of apoptotic process involved in metanephric nephron tubule development Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development. go.json down regulation of apoptosis of metanephric nephron tubule development|down regulation of apoptotic cell death of metanephric nephron tubule development|down regulation of apoptotic process involved in metanephric nephron tubule development|down regulation of apoptotic process of metanephric nephron tubule development|down regulation of apoptotic program of metanephric nephron tubule development|down regulation of apoptotic programmed cell death of metanephric nephron tubule development|down regulation of programmed cell death by apoptosis of metanephric nephron tubule development|down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|down regulation of type I programmed cell death of metanephric nephron tubule development|down-regulation of apoptosis of metanephric nephron tubule development|down-regulation of apoptotic cell death of metanephric nephron tubule development|down-regulation of apoptotic process involved in metanephric nephron tubule development|down-regulation of apoptotic process of metanephric nephron tubule development|down-regulation of apoptotic program of metanephric nephron tubule development|down-regulation of apoptotic programmed cell death of metanephric nephron tubule development|down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development|down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|down-regulation of type I programmed cell death of metanephric nephron tubule development|downregulation of apoptosis of metanephric nephron tubule development|downregulation of apoptotic cell death of metanephric nephron tubule development|downregulation of apoptotic process involved in metanephric nephron tubule development|downregulation of apoptotic process of metanephric nephron tubule development|downregulation of apoptotic program of metanephric nephron tubule development|downregulation of apoptotic programmed cell death of metanephric nephron tubule development|downregulation of programmed cell death by apoptosis of metanephric nephron tubule development|downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development|downregulation of type I programmed cell death of metanephric nephron tubule development|inhibition of apoptosis of metanephric nephron tubule development|inhibition of apoptotic cell death of metanephric nephron tubule development|inhibition of apoptotic process involved in metanephric nephron tubule development|inhibition of apoptotic process of metanephric nephron tubule development|inhibition of apoptotic program of metanephric nephron tubule development|inhibition of apoptotic programmed cell death of metanephric nephron tubule development|inhibition of programmed cell death by apoptosis of metanephric nephron tubule development|inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development|inhibition of type I programmed cell death of metanephric nephron tubule development|negative regulation of apoptosis of metanephric nephron tubule development|negative regulation of apoptotic cell death of metanephric nephron tubule development|negative regulation of apoptotic process of metanephric nephron tubule development|negative regulation of apoptotic program of metanephric nephron tubule development|negative regulation of apoptotic programmed cell death of metanephric nephron tubule development|negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development|negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development|negative regulation of type I programmed cell death of metanephric nephron tubule development http://purl.obolibrary.org/obo/GO_1900218 GO:1900213 biolink:BiologicalProcess positive regulation of mesenchymal cell apoptotic process involved in metanephros development Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development. go.json activation of mesenchymal cell apoptosis involved in metanephros development|positive regulation of mesenchymal cell apoptosis involved in metanephros development|up regulation of mesenchymal cell apoptosis involved in metanephros development|up-regulation of mesenchymal cell apoptosis involved in metanephros development|upregulation of mesenchymal cell apoptosis involved in metanephros development http://purl.obolibrary.org/obo/GO_1900213 GO:1900212 biolink:BiologicalProcess negative regulation of mesenchymal cell apoptotic process involved in metanephros development Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development. go.json down regulation of mesenchymal cell apoptosis involved in metanephros development|down-regulation of mesenchymal cell apoptosis involved in metanephros development|downregulation of mesenchymal cell apoptosis involved in metanephros development|inhibition of mesenchymal cell apoptosis involved in metanephros development|negative regulation of mesenchymal cell apoptosis involved in metanephros development http://purl.obolibrary.org/obo/GO_1900212 GO:1900215 biolink:BiologicalProcess negative regulation of apoptotic process involved in metanephric collecting duct development Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development. go.json down regulation of apoptosis of metanephric collecting duct development|down regulation of apoptotic cell death of metanephric collecting duct development|down regulation of apoptotic process involved in metanephric collecting duct development|down regulation of apoptotic process of metanephric collecting duct development|down regulation of apoptotic program of metanephric collecting duct development|down regulation of apoptotic programmed cell death of metanephric collecting duct development|down regulation of programmed cell death by apoptosis of metanephric collecting duct development|down regulation of signaling (initiator) caspase activity of metanephric collecting duct development|down regulation of type I programmed cell death of metanephric collecting duct development|down-regulation of apoptosis of metanephric collecting duct development|down-regulation of apoptotic cell death of metanephric collecting duct development|down-regulation of apoptotic process involved in metanephric collecting duct development|down-regulation of apoptotic process of metanephric collecting duct development|down-regulation of apoptotic program of metanephric collecting duct development|down-regulation of apoptotic programmed cell death of metanephric collecting duct development|down-regulation of programmed cell death by apoptosis of metanephric collecting duct development|down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development|down-regulation of type I programmed cell death of metanephric collecting duct development|downregulation of apoptosis of metanephric collecting duct development|downregulation of apoptotic cell death of metanephric collecting duct development|downregulation of apoptotic process involved in metanephric collecting duct development|downregulation of apoptotic process of metanephric collecting duct development|downregulation of apoptotic program of metanephric collecting duct development|downregulation of apoptotic programmed cell death of metanephric collecting duct development|downregulation of programmed cell death by apoptosis of metanephric collecting duct development|downregulation of signaling (initiator) caspase activity of metanephric collecting duct development|downregulation of type I programmed cell death of metanephric collecting duct development|inhibition of apoptosis of metanephric collecting duct development|inhibition of apoptotic cell death of metanephric collecting duct development|inhibition of apoptotic process involved in metanephric collecting duct development|inhibition of apoptotic process of metanephric collecting duct development|inhibition of apoptotic program of metanephric collecting duct development|inhibition of apoptotic programmed cell death of metanephric collecting duct development|inhibition of programmed cell death by apoptosis of metanephric collecting duct development|inhibition of signaling (initiator) caspase activity of metanephric collecting duct development|inhibition of type I programmed cell death of metanephric collecting duct development|negative regulation of apoptosis of metanephric collecting duct development|negative regulation of apoptotic cell death of metanephric collecting duct development|negative regulation of apoptotic process of metanephric collecting duct development|negative regulation of apoptotic program of metanephric collecting duct development|negative regulation of apoptotic programmed cell death of metanephric collecting duct development|negative regulation of programmed cell death by apoptosis of metanephric collecting duct development|negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development|negative regulation of type I programmed cell death of metanephric collecting duct development http://purl.obolibrary.org/obo/GO_1900215 GO:0046149 biolink:BiologicalProcess pigment catabolic process The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. go.json pigment breakdown|pigment catabolism|pigment degradation http://purl.obolibrary.org/obo/GO_0046149 GO:0046148 biolink:BiologicalProcess pigment biosynthetic process The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. go.json pigment anabolism|pigment biosynthesis|pigment formation|pigment synthesis http://purl.obolibrary.org/obo/GO_0046148 GO:1900214 biolink:BiologicalProcess regulation of apoptotic process involved in metanephric collecting duct development Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development. go.json regulation of apoptosis of metanephric collecting duct development|regulation of apoptotic cell death of metanephric collecting duct development|regulation of apoptotic process of metanephric collecting duct development|regulation of apoptotic program of metanephric collecting duct development|regulation of apoptotic programmed cell death of metanephric collecting duct development|regulation of programmed cell death by apoptosis of metanephric collecting duct development|regulation of signaling (initiator) caspase activity of metanephric collecting duct development|regulation of type I programmed cell death of metanephric collecting duct development http://purl.obolibrary.org/obo/GO_1900214 GO:0046147 biolink:BiologicalProcess tetrahydrobiopterin catabolic process The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. go.json 5,6,7,8-tetrahydrobiopterin catabolic process|tetrahydrobiopterin breakdown|tetrahydrobiopterin catabolism|tetrahydrobiopterin degradation http://purl.obolibrary.org/obo/GO_0046147 GO:0061780 biolink:BiologicalProcess mitotic cohesin loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0061780 GO:0046146 biolink:BiologicalProcess tetrahydrobiopterin metabolic process The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. go.json 5,6,7,8-tetrahydrobiopterin metabolic process|tetrahydrobiopterin metabolism http://purl.obolibrary.org/obo/GO_0046146 GO:0061782 biolink:BiologicalProcess vesicle fusion with vesicle Fusion of the membrane of a transport vesicle with a target membrane on another vesicle. go.json vesicle to vesicle fusion|vesicle-vesicle fusion http://purl.obolibrary.org/obo/GO_0061782 GO:1900211 biolink:BiologicalProcess regulation of mesenchymal cell apoptotic process involved in metanephros development Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development. go.json regulation of mesenchymal cell apoptosis involved in metanephros development http://purl.obolibrary.org/obo/GO_1900211 GO:0046145 biolink:BiologicalProcess obsolete D-alanine family amino acid biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids. go.json D-alanine family amino acid anabolism|D-alanine family amino acid biosynthesis|D-alanine family amino acid formation|D-alanine family amino acid synthesis True http://purl.obolibrary.org/obo/GO_0046145 GO:0046144 biolink:BiologicalProcess obsolete D-alanine family amino acid metabolic process OBSOLETE. The chemical reactions and pathways involving D-alanine and related amino acids. go.json D-alanine family amino acid metabolism True http://purl.obolibrary.org/obo/GO_0046144 GO:0061781 biolink:BiologicalProcess mitotic cohesin unloading Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle. go.json http://purl.obolibrary.org/obo/GO_0061781 gocheck_do_not_annotate GO:1900210 biolink:BiologicalProcess positive regulation of cardiolipin metabolic process Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process. go.json activation of cardiolipin metabolic process|activation of cardiolipin metabolism|activation of diphosphatidylglycerol metabolic process|activation of diphosphatidylglycerol metabolism|positive regulation of cardiolipin metabolism|positive regulation of diphosphatidylglycerol metabolic process|positive regulation of diphosphatidylglycerol metabolism|up regulation of cardiolipin metabolic process|up regulation of cardiolipin metabolism|up regulation of diphosphatidylglycerol metabolic process|up regulation of diphosphatidylglycerol metabolism|up-regulation of cardiolipin metabolic process|up-regulation of cardiolipin metabolism|up-regulation of diphosphatidylglycerol metabolic process|up-regulation of diphosphatidylglycerol metabolism|upregulation of cardiolipin metabolic process|upregulation of cardiolipin metabolism|upregulation of diphosphatidylglycerol metabolic process|upregulation of diphosphatidylglycerol metabolism http://purl.obolibrary.org/obo/GO_1900210 GO:0061784 biolink:MolecularActivity peptidoglycan N-acetylglucosaminidase activity Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0061784 GO:0061783 biolink:MolecularActivity peptidoglycan muralytic activity A catalytic activity that contributes to the degradation of peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0061783 GO:0061786 biolink:MolecularActivity peptidoglycan stem peptide endopeptidase activity A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0061786 GO:0061785 biolink:MolecularActivity peptidoglycan endopeptidase activity An endopeptidase activity that uses peptidoglycan as a substrate. go.json http://purl.obolibrary.org/obo/GO_0061785 GO:0061788 biolink:MolecularActivity EGF repeat binding Binding to Epidermal Growth Factor (EGF) repeats. go.json Epidermal Growth Factor repeat binding|Epidermal growth factor domain binding http://purl.obolibrary.org/obo/GO_0061788 GO:0061787 biolink:MolecularActivity peptidoglycan cross-bridge peptide endopeptidase activity A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge. go.json lysostaphin activity http://purl.obolibrary.org/obo/GO_0061787 GO:0071109 biolink:BiologicalProcess superior temporal gyrus development The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus. go.json http://purl.obolibrary.org/obo/GO_0071109 GO:0071108 biolink:BiologicalProcess protein K48-linked deubiquitination A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. go.json http://purl.obolibrary.org/obo/GO_0071108 gocheck_do_not_annotate GO:0061789 biolink:BiologicalProcess dense core granule priming A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking. go.json LDCV priming|dense core vesicle priming|large dense-core vesicle priming http://purl.obolibrary.org/obo/GO_0061789 GO:0071107 biolink:BiologicalProcess response to parathyroid hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. go.json response to parathyroid hormone stimulus http://purl.obolibrary.org/obo/GO_0071107 GO:0071106 biolink:BiologicalProcess adenosine 3',5'-bisphosphate transmembrane transport The process in which adenosine 3',5'-bisphosphate is transported across a membrane. go.json adenosine 3',5'-bisphosphate membrane transport|adenosine 3',5'-diphosphate transport|adenosine 3'-phosphate-5'-phosphate transmembrane transport http://purl.obolibrary.org/obo/GO_0071106 GO:0071105 biolink:BiologicalProcess response to interleukin-11 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus. go.json response to IL-11 http://purl.obolibrary.org/obo/GO_0071105 GO:0071104 biolink:BiologicalProcess response to interleukin-9 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. go.json response to IL-9 http://purl.obolibrary.org/obo/GO_0071104 GO:0071103 biolink:BiologicalProcess DNA conformation change A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. go.json DNA conformation modification http://purl.obolibrary.org/obo/GO_0071103 goslim_metagenomics GO:0071102 biolink:CellularComponent alpha4-beta1 integrin-paxillin complex A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin. go.json ITGA4-ITGB1-PXN complex http://purl.obolibrary.org/obo/GO_0071102 GO:0071101 biolink:CellularComponent alpha4-beta1 integrin-JAM2 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2. go.json ITGA4-ITGB1-JAM2 complex http://purl.obolibrary.org/obo/GO_0071101 GO:0071100 biolink:CellularComponent alphaV-beta8 integrin-MMP14-TGFbeta-1 complex A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1). go.json ITGAV-ITGB8-MMP14-TGFB1 complex http://purl.obolibrary.org/obo/GO_0071100 GO:0046154 biolink:BiologicalProcess rhodopsin metabolic process The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. go.json rhodopsin metabolism http://purl.obolibrary.org/obo/GO_0046154 GO:0046153 biolink:BiologicalProcess ommochrome catabolic process The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. go.json ommochrome breakdown|ommochrome catabolism|ommochrome degradation http://purl.obolibrary.org/obo/GO_0046153 GO:0046152 biolink:BiologicalProcess ommochrome metabolic process The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. go.json ommochrome metabolism http://purl.obolibrary.org/obo/GO_0046152 GO:0046151 biolink:BiologicalProcess eye pigment catabolic process The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. go.json eye pigment breakdown|eye pigment catabolism|eye pigment degradation http://purl.obolibrary.org/obo/GO_0046151 GO:1900228 biolink:BiologicalProcess regulation of single-species biofilm formation in or on host organism Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism. go.json http://purl.obolibrary.org/obo/GO_1900228 GO:0046150 biolink:BiologicalProcess melanin catabolic process The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. go.json melanin breakdown|melanin catabolism|melanin degradation http://purl.obolibrary.org/obo/GO_0046150 GO:1900227 biolink:BiologicalProcess positive regulation of NLRP3 inflammasome complex assembly Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly. go.json activation of NALP3 inflammasome complex assembly|activation of NLRP3 inflammasome activation|activation of NLRP3 inflammasome complex assembly|positive regulation of NALP3 inflammasome complex assembly|positive regulation of NLRP3 inflammasome activation|up regulation of NALP3 inflammasome complex assembly|up regulation of NLRP3 inflammasome activation|up regulation of NLRP3 inflammasome complex assembly|up-regulation of NALP3 inflammasome complex assembly|up-regulation of NLRP3 inflammasome activation|up-regulation of NLRP3 inflammasome complex assembly|upregulation of NALP3 inflammasome complex assembly|upregulation of NLRP3 inflammasome activation|upregulation of NLRP3 inflammasome complex assembly http://purl.obolibrary.org/obo/GO_1900227 GO:1900229 biolink:BiologicalProcess negative regulation of single-species biofilm formation in or on host organism Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism. go.json down regulation of single-species biofilm formation in or on host organism|down-regulation of single-species biofilm formation in or on host organism|downregulation of single-species biofilm formation in or on host organism|inhibition of single-species biofilm formation in or on host organism http://purl.obolibrary.org/obo/GO_1900229 GO:1900224 biolink:BiologicalProcess obsolete positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. go.json activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm True http://purl.obolibrary.org/obo/GO_1900224 GO:1900223 biolink:BiologicalProcess positive regulation of amyloid-beta clearance Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance. go.json activation of beta-amyloid clearance|positive regulation of beta-amyloid clearance|up regulation of beta-amyloid clearance|up-regulation of beta-amyloid clearance|upregulation of beta-amyloid clearance http://purl.obolibrary.org/obo/GO_1900223 GO:1900226 biolink:BiologicalProcess negative regulation of NLRP3 inflammasome complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly. go.json down regulation of NALP3 inflammasome complex assembly|down regulation of NLRP3 inflammasome activation|down regulation of NLRP3 inflammasome complex assembly|down-regulation of NALP3 inflammasome complex assembly|down-regulation of NLRP3 inflammasome activation|down-regulation of NLRP3 inflammasome complex assembly|downregulation of NALP3 inflammasome complex assembly|downregulation of NLRP3 inflammasome activation|downregulation of NLRP3 inflammasome complex assembly|inhibition of NALP3 inflammasome complex assembly|inhibition of NLRP3 inflammasome activation|inhibition of NLRP3 inflammasome complex assembly|negative regulation of NALP3 inflammasome complex assembly|negative regulation of NLRP3 inflammasome activation http://purl.obolibrary.org/obo/GO_1900226 GO:0046159 biolink:BiologicalProcess ocellus pigment catabolic process The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. go.json ocellus pigment breakdown|ocellus pigment catabolism|ocellus pigment degradation http://purl.obolibrary.org/obo/GO_0046159 GO:1900225 biolink:BiologicalProcess regulation of NLRP3 inflammasome complex assembly Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. go.json regulation of NALP3 inflammasome complex assembly|regulation of NLRP3 inflammasome activation http://purl.obolibrary.org/obo/GO_1900225 GO:0046158 biolink:BiologicalProcess ocellus pigment metabolic process The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. go.json ocellus pigment metabolism http://purl.obolibrary.org/obo/GO_0046158 GO:1900220 biolink:BiologicalProcess semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis. go.json semaphorin-plexin signaling pathway of bone trabecula morphogenesis|semaphorin-plexin signalling pathway of bone trabecula morphogenesis http://purl.obolibrary.org/obo/GO_1900220 GO:0046157 biolink:BiologicalProcess siroheme catabolic process The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. go.json sirohaem catabolic process|sirohaem catabolism|siroheme breakdown|siroheme catabolism|siroheme degradation http://purl.obolibrary.org/obo/GO_0046157 GO:1900222 biolink:BiologicalProcess negative regulation of amyloid-beta clearance Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance. go.json down regulation of beta-amyloid clearance|down-regulation of beta-amyloid clearance|downregulation of beta-amyloid clearance|inhibition of beta-amyloid clearance|negative regulation of beta-amyloid clearance http://purl.obolibrary.org/obo/GO_1900222 GO:0046156 biolink:BiologicalProcess siroheme metabolic process The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. go.json sirohaem metabolic process|sirohaem metabolism|siroheme metabolism http://purl.obolibrary.org/obo/GO_0046156 GO:0061771 biolink:BiologicalProcess response to caloric restriction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake. go.json http://purl.obolibrary.org/obo/GO_0061771 GO:1900221 biolink:BiologicalProcess regulation of amyloid-beta clearance Any process that modulates the frequency, rate or extent of amyloid-beta clearance. go.json regulation of beta-amyloid clearance http://purl.obolibrary.org/obo/GO_1900221 GO:0046155 biolink:BiologicalProcess rhodopsin catabolic process The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. go.json rhodopsin breakdown|rhodopsin catabolism|rhodopsin degradation http://purl.obolibrary.org/obo/GO_0046155 GO:0061770 biolink:MolecularActivity translation elongation factor binding Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation. go.json http://purl.obolibrary.org/obo/GO_0061770 GO:0061773 biolink:CellularComponent eNoSc complex A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation. go.json energy dependent nucleolar silencing complex http://purl.obolibrary.org/obo/GO_0061773 GO:0061772 biolink:BiologicalProcess xenobiotic transport across blood-nerve barrier The directed movement of a xenobiotic through the blood-nerve barrier. go.json drug transport across blood-nerve barrier|drug transport across perineurial barrier http://purl.obolibrary.org/obo/GO_0061772 GO:0061775 biolink:MolecularActivity cohesin loader activity Facilitating a conformational change to load a cohesin complex around sister chromatids. go.json cohesin loading activity http://purl.obolibrary.org/obo/GO_0061775 GO:0061774 biolink:BiologicalProcess cohesin unloading Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA. go.json DNA exit from the cohesin ring http://purl.obolibrary.org/obo/GO_0061774 gocheck_do_not_annotate GO:0061777 biolink:MolecularActivity obsolete DNA clamp activity OBSOLETE. A DNA binding activity in which a protein complex interacts selectively and non-covalently with single DNA duplex to tightly encircle the DNA. go.json True http://purl.obolibrary.org/obo/GO_0061777 GO:0061776 biolink:MolecularActivity topological DNA co-entrapment activity A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring. go.json topological DNA entrapment activity http://purl.obolibrary.org/obo/GO_0061776 GO:0061779 biolink:CellularComponent Tapasin-ERp57 complex Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role. go.json http://purl.obolibrary.org/obo/GO_0061779 GO:0061778 biolink:MolecularActivity intracellular chloride channel activity Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. go.json http://purl.obolibrary.org/obo/GO_0061778 GO:0061900 biolink:BiologicalProcess glial cell activation A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0061900 GO:0061902 biolink:BiologicalProcess obsolete negative regulation of 1-phosphatidylinositol-3-kinase activity OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity. go.json True http://purl.obolibrary.org/obo/GO_0061902 GO:0061901 biolink:BiologicalProcess obsolete regulation of 1-phosphatidylinositol-3-kinase activity OBSOLETE. Any process that modulates the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity. go.json True http://purl.obolibrary.org/obo/GO_0061901 GO:0061903 biolink:BiologicalProcess obsolete positive regulation of 1-phosphatidylinositol-3-kinase activity OBSOLETE. Any process that starts or increases the frequency or rate of 1-phosphatidylinositol-3-kinase activity. go.json True http://purl.obolibrary.org/obo/GO_0061903 GO:0061906 biolink:BiologicalProcess autophagosome localization Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell. go.json http://purl.obolibrary.org/obo/GO_0061906 GO:0061908 biolink:CellularComponent phagophore A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle. go.json isolation membrane http://purl.obolibrary.org/obo/GO_0061908 GO:0061907 biolink:BiologicalProcess negative regulation of AMPA receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity. go.json http://purl.obolibrary.org/obo/GO_0061907 gocheck_do_not_annotate GO:0061920 biolink:MolecularActivity protein propionyltransferase activity Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide. RHEA:54020 go.json http://purl.obolibrary.org/obo/GO_0061920 GO:0061922 biolink:MolecularActivity histone propionyltransferase activity Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone. go.json http://purl.obolibrary.org/obo/GO_0061922 GO:0061921 biolink:BiologicalProcess peptidyl-lysine propionylation The propionylation of peptidyl-lysine. go.json http://purl.obolibrary.org/obo/GO_0061921 gocheck_do_not_annotate GO:0061924 biolink:BiologicalProcess regulation of formation of radial glial scaffolds Any process that modulates the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells. go.json regulation of Bergmann fiber biosynthesis|regulation of Bergmann fiber formation|regulation of radial glial scaffold formation http://purl.obolibrary.org/obo/GO_0061924 GO:0061923 biolink:MolecularActivity (2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene. go.json protoillud-7-ene synthase activity http://purl.obolibrary.org/obo/GO_0061923 GO:0061926 biolink:BiologicalProcess positive regulation of formation of radial glial scaffolds Any process that increases the frequency, rate or extent of the formation of radial glial cell scaffolds. go.json positive regulation of Bergmann fiber biosynthesis|positive regulation of Bergmann fiber formation|positive regulation of radial glial scaffold formation http://purl.obolibrary.org/obo/GO_0061926 GO:0061925 biolink:BiologicalProcess negative regulation of formation of radial glial scaffolds Any process that reduces the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells. go.json negative regulation of Bergmann fiber biosynthesis|negative regulation of Bergmann fiber formation|negative regulation of radial glial scaffold formation http://purl.obolibrary.org/obo/GO_0061925 GO:0061928 biolink:MolecularActivity glutathione specific gamma-glutamylcyclotransferase activity Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine. EC:4.3.2.7|RHEA:47724 go.json http://purl.obolibrary.org/obo/GO_0061928 GO:0061927 biolink:CellularComponent TOC-TIC supercomplex I The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110. go.json http://purl.obolibrary.org/obo/GO_0061927 GO:0061929 biolink:MolecularActivity gamma-glutamylaminecyclotransferase activity Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline. EC:4.3.2.8|RHEA:16961 go.json http://purl.obolibrary.org/obo/GO_0061929 GO:0061909 biolink:BiologicalProcess autophagosome-lysosome fusion The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome. go.json autophagosome fusion|autophagosome-vacuole fusion http://purl.obolibrary.org/obo/GO_0061909 GO:0061911 biolink:BiologicalProcess amphisome-lysosome fusion The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome. go.json http://purl.obolibrary.org/obo/GO_0061911 GO:0061910 biolink:BiologicalProcess autophagosome-endosome fusion The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome. go.json http://purl.obolibrary.org/obo/GO_0061910 GO:0061913 biolink:BiologicalProcess positive regulation of growth plate cartilage chondrocyte proliferation Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0061913 GO:0061912 biolink:BiologicalProcess obsolete selective autophagy OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process. go.json True http://purl.obolibrary.org/obo/GO_0061912 GO:0061915 biolink:BiologicalProcess obsolete actin fusion focus localization OBSOLETE. Any process in which an actin fusion focus are transported to, or maintained in, a specific location. The actin fusion focus is an aster-like, F-actin-containing structure at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. go.json actin fusion focus localisation True http://purl.obolibrary.org/obo/GO_0061915 GO:0061914 biolink:BiologicalProcess negative regulation of growth plate cartilage chondrocyte proliferation Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0061914 GO:0061917 biolink:CellularComponent leading edge of dendritic growth cone That part of the dendritic growth cone which represents the distal part of the structure. go.json dendritic growth cone leading edge|distal tip of dendritic growth cone http://purl.obolibrary.org/obo/GO_0061917 GO:0061916 biolink:CellularComponent leading edge of axonal growth cone That part of the axonal growth cone which represents the distal part of the structure. go.json axonal growth cone leading edge|distal tip of axonal growth cone http://purl.obolibrary.org/obo/GO_0061916 GO:0061919 biolink:BiologicalProcess process utilizing autophagic mechanism A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway. go.json http://purl.obolibrary.org/obo/GO_0061919 gocheck_do_not_annotate GO:0046305 biolink:BiologicalProcess alkanesulfonate biosynthetic process The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. go.json alkanesulfonate anabolism|alkanesulfonate biosynthesis|alkanesulfonate formation|alkanesulfonate synthesis|alkanesulphonate biosynthesis|alkanesulphonate biosynthetic process http://purl.obolibrary.org/obo/GO_0046305 GO:0046304 biolink:BiologicalProcess 2-nitropropane catabolic process The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. go.json 2-nitropropane breakdown|2-nitropropane catabolism|2-nitropropane degradation http://purl.obolibrary.org/obo/GO_0046304 GO:0046303 biolink:BiologicalProcess obsolete 2-nitropropane biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. go.json 2-nitropropane anabolism|2-nitropropane biosynthesis|2-nitropropane biosynthetic process|2-nitropropane formation|2-nitropropane synthesis True http://purl.obolibrary.org/obo/GO_0046303 GO:0046302 biolink:BiologicalProcess 2-chloro-N-isopropylacetanilide catabolic process The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. go.json 2-chloro-N-isopropylacetanilide breakdown|2-chloro-N-isopropylacetanilide catabolism|2-chloro-N-isopropylacetanilide degradation http://purl.obolibrary.org/obo/GO_0046302 GO:0046301 biolink:BiologicalProcess obsolete 2-chloro-N-isopropylacetanilide biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. go.json 2-chloro-N-isopropylacetanilide anabolism|2-chloro-N-isopropylacetanilide biosynthesis|2-chloro-N-isopropylacetanilide biosynthetic process|2-chloro-N-isopropylacetanilide formation|2-chloro-N-isopropylacetanilide synthesis True http://purl.obolibrary.org/obo/GO_0046301 GO:0046300 biolink:BiologicalProcess 2,4-dichlorophenoxyacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. go.json 2,4-dichlorophenoxyacetic acid breakdown|2,4-dichlorophenoxyacetic acid catabolism|2,4-dichlorophenoxyacetic acid degradation http://purl.obolibrary.org/obo/GO_0046300 GO:0061940 biolink:BiologicalProcess regulation of c-di-GMP signaling Any process that modulates the rate frequency or extent of c-di-GMP signaling. go.json http://purl.obolibrary.org/obo/GO_0061940 GO:0046309 biolink:BiologicalProcess obsolete 1,3-dichloro-2-propanol biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. go.json 1,3-dichloro-2-propanol anabolism|1,3-dichloro-2-propanol biosynthesis|1,3-dichloro-2-propanol formation|1,3-dichloro-2-propanol synthesis True http://purl.obolibrary.org/obo/GO_0046309 GO:0061942 biolink:BiologicalProcess negative regulation of c-di-GMP signaling Any process that decreases the rate, frequency or extent of c-di-GMP signaling. go.json http://purl.obolibrary.org/obo/GO_0061942 GO:0046308 biolink:BiologicalProcess Z-phenylacetaldoxime catabolic process The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds. go.json Z-phenylacetaldoxime breakdown|Z-phenylacetaldoxime catabolism|Z-phenylacetaldoxime degradation http://purl.obolibrary.org/obo/GO_0046308 GO:0061941 biolink:BiologicalProcess positive regulation of c-di-GMP signaling Any process that increases the rate, frequency or extent of c-di-GMP signaling. go.json http://purl.obolibrary.org/obo/GO_0061941 GO:0046307 biolink:BiologicalProcess Z-phenylacetaldoxime biosynthetic process The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds. go.json Z-phenylacetaldoxime anabolism|Z-phenylacetaldoxime biosynthesis|Z-phenylacetaldoxime formation|Z-phenylacetaldoxime synthesis http://purl.obolibrary.org/obo/GO_0046307 GO:0061944 biolink:BiologicalProcess negative regulation of protein K48-linked ubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. go.json http://purl.obolibrary.org/obo/GO_0061944 GO:0046306 biolink:BiologicalProcess alkanesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. go.json alkanesulfonate breakdown|alkanesulfonate catabolism|alkanesulfonate degradation|alkanesulphonate catabolic process|alkanesulphonate catabolism http://purl.obolibrary.org/obo/GO_0046306 GO:0061945 biolink:BiologicalProcess regulation of protein K48-linked ubiquitination Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. go.json http://purl.obolibrary.org/obo/GO_0061945 GO:0061948 biolink:BiologicalProcess premature acrosome loss The discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. go.json spontaneous acrosome loss http://purl.obolibrary.org/obo/GO_0061948 GO:0061949 biolink:BiologicalProcess regulation of premature acrosome loss Any process that modulates the rate, frequency or extent of the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. go.json http://purl.obolibrary.org/obo/GO_0061949 GO:0046316 biolink:MolecularActivity gluconokinase activity Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+. EC:2.7.1.12|KEGG_REACTION:R01737|MetaCyc:GLUCONOKIN-RXN|RHEA:19433 go.json ATP:D-gluconate 6-phosphotransferase activity|gluconate kinase activity|gluconokinase (phosphorylating) http://purl.obolibrary.org/obo/GO_0046316 GO:0046315 biolink:BiologicalProcess phosphocreatine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. go.json phosphocreatine breakdown|phosphocreatine catabolism|phosphocreatine degradation http://purl.obolibrary.org/obo/GO_0046315 GO:0046314 biolink:BiologicalProcess phosphocreatine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. go.json phosphocreatine anabolism|phosphocreatine biosynthesis|phosphocreatine formation|phosphocreatine synthesis http://purl.obolibrary.org/obo/GO_0046314 GO:0046313 biolink:BiologicalProcess phosphoarginine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine. go.json phosphoarginine breakdown|phosphoarginine catabolism|phosphoarginine degradation http://purl.obolibrary.org/obo/GO_0046313 GO:0046312 biolink:BiologicalProcess phosphoarginine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine. go.json phosphoarginine anabolism|phosphoarginine biosynthesis|phosphoarginine formation|phosphoarginine synthesis http://purl.obolibrary.org/obo/GO_0046312 GO:0046311 biolink:BiologicalProcess prenylcysteine biosynthetic process The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. go.json prenylcysteine anabolism|prenylcysteine biosynthesis|prenylcysteine formation|prenylcysteine synthesis http://purl.obolibrary.org/obo/GO_0046311 GO:0046310 biolink:BiologicalProcess obsolete 1,3-dichloro-2-propanol catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. go.json 1,3-dichloro-2-propanol breakdown|1,3-dichloro-2-propanol catabolism|1,3-dichloro-2-propanol degradation True http://purl.obolibrary.org/obo/GO_0046310 GO:0061931 biolink:BiologicalProcess positive regulation of erythrocyte enucleation Any process that increases the frequency, rate or extent of erythrocyte enucleation. go.json http://purl.obolibrary.org/obo/GO_0061931 GO:0046319 biolink:BiologicalProcess positive regulation of glucosylceramide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. go.json activation of glucosylceramide biosynthetic process|positive regulation of glucosylceramide anabolism|positive regulation of glucosylceramide biosynthesis|positive regulation of glucosylceramide formation|positive regulation of glucosylceramide synthesis|stimulation of glucosylceramide biosynthetic process|up regulation of glucosylceramide biosynthetic process|up-regulation of glucosylceramide biosynthetic process|upregulation of glucosylceramide biosynthetic process http://purl.obolibrary.org/obo/GO_0046319 GO:0061930 biolink:BiologicalProcess regulation of erythrocyte enucleation Any process that modulates the frequency, rate or extent of erythrocyte enucleation. go.json http://purl.obolibrary.org/obo/GO_0061930 GO:0046318 biolink:BiologicalProcess negative regulation of glucosylceramide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. go.json down regulation of glucosylceramide biosynthetic process|down-regulation of glucosylceramide biosynthetic process|downregulation of glucosylceramide biosynthetic process|inhibition of glucosylceramide biosynthetic process|negative regulation of glucosylceramide anabolism|negative regulation of glucosylceramide biosynthesis|negative regulation of glucosylceramide formation|negative regulation of glucosylceramide synthesis http://purl.obolibrary.org/obo/GO_0046318 GO:0046317 biolink:BiologicalProcess regulation of glucosylceramide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. go.json regulation of glucosylceramide anabolism|regulation of glucosylceramide biosynthesis|regulation of glucosylceramide formation|regulation of glucosylceramide synthesis http://purl.obolibrary.org/obo/GO_0046317 GO:0061932 biolink:BiologicalProcess negative regulation of erythrocyte enucleation Any process that decreases the frequency, rate or extent of erythrocyte enucleation. go.json http://purl.obolibrary.org/obo/GO_0061932 GO:0061935 biolink:BiologicalProcess fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes. go.json http://purl.obolibrary.org/obo/GO_0061935 GO:0061934 biolink:BiologicalProcess regulation of adenine biosynthetic process Any process that modulates the frequency, rate or extent of an adenine biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_0061934 GO:0061936 biolink:BiologicalProcess fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming a zygote and endosperm. go.json http://purl.obolibrary.org/obo/GO_0061936 GO:0061939 biolink:BiologicalProcess c-di-GMP signaling Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal. go.json 3',5'-cyclic di-GMP signaling|cyclic di-(3':5')-guanosine monophosphate signaling|cyclic di-GMP signaling|cyclic diguanylate signaling http://purl.obolibrary.org/obo/GO_0061939 GO:0061938 biolink:BiologicalProcess protein localization to somatodendritic compartment A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. go.json somatodendritic protein localization http://purl.obolibrary.org/obo/GO_0061938 GO:1900198 biolink:BiologicalProcess positive regulation of penicillin biosynthetic process Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process. go.json activation of penicillin anabolism|activation of penicillin biosynthesis|activation of penicillin biosynthetic process|activation of penicillin formation|activation of penicillin synthesis|positive regulation of penicillin anabolism|positive regulation of penicillin biosynthesis|positive regulation of penicillin formation|positive regulation of penicillin synthesis|up regulation of penicillin anabolism|up regulation of penicillin biosynthesis|up regulation of penicillin biosynthetic process|up regulation of penicillin formation|up regulation of penicillin synthesis|up-regulation of penicillin anabolism|up-regulation of penicillin biosynthesis|up-regulation of penicillin biosynthetic process|up-regulation of penicillin formation|up-regulation of penicillin synthesis|upregulation of penicillin anabolism|upregulation of penicillin biosynthesis|upregulation of penicillin biosynthetic process|upregulation of penicillin formation|upregulation of penicillin synthesis http://purl.obolibrary.org/obo/GO_1900198 GO:1900197 biolink:BiologicalProcess negative regulation of penicillin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process. go.json down regulation of penicillin anabolism|down regulation of penicillin biosynthesis|down regulation of penicillin biosynthetic process|down regulation of penicillin formation|down regulation of penicillin synthesis|down-regulation of penicillin anabolism|down-regulation of penicillin biosynthesis|down-regulation of penicillin biosynthetic process|down-regulation of penicillin formation|down-regulation of penicillin synthesis|downregulation of penicillin anabolism|downregulation of penicillin biosynthesis|downregulation of penicillin biosynthetic process|downregulation of penicillin formation|downregulation of penicillin synthesis|inhibition of penicillin anabolism|inhibition of penicillin biosynthesis|inhibition of penicillin biosynthetic process|inhibition of penicillin formation|inhibition of penicillin synthesis|negative regulation of penicillin anabolism|negative regulation of penicillin biosynthesis|negative regulation of penicillin formation|negative regulation of penicillin synthesis http://purl.obolibrary.org/obo/GO_1900197 GO:1900199 biolink:BiologicalProcess positive regulation of protein export from nucleus during meiotic anaphase II Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm, during anaphase occurring as part of meiosis II. go.json positive regulation of protein export from nucleus involved in meiotic anaphase II http://purl.obolibrary.org/obo/GO_1900199 GO:0071242 biolink:BiologicalProcess cellular response to ammonium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. go.json cellular response to ammonia http://purl.obolibrary.org/obo/GO_0071242 GO:0046286 biolink:BiologicalProcess flavonoid phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. go.json flavonoid phytoalexin breakdown|flavonoid phytoalexin catabolism|flavonoid phytoalexin degradation http://purl.obolibrary.org/obo/GO_0046286 GO:0071241 biolink:BiologicalProcess cellular response to inorganic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. go.json http://purl.obolibrary.org/obo/GO_0071241 GO:0046285 biolink:BiologicalProcess flavonoid phytoalexin metabolic process The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. go.json flavonoid phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0046285 GO:0046284 biolink:BiologicalProcess anthocyanin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. go.json anthocyanin breakdown|anthocyanin catabolic process|anthocyanin catabolism|anthocyanin degradation http://purl.obolibrary.org/obo/GO_0046284 GO:0071240 biolink:BiologicalProcess cellular response to food Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. go.json http://purl.obolibrary.org/obo/GO_0071240 GO:0046283 biolink:BiologicalProcess anthocyanin-containing compound metabolic process The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers. go.json anthocyanin metabolic process|anthocyanin metabolism http://purl.obolibrary.org/obo/GO_0046283 GO:0046282 biolink:BiologicalProcess cinnamic acid ester catabolic process The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid. go.json cinnamic acid ester breakdown|cinnamic acid ester catabolism|cinnamic acid ester degradation http://purl.obolibrary.org/obo/GO_0046282 GO:1900118 biolink:BiologicalProcess negative regulation of execution phase of apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. go.json down regulation of execution phase of apoptosis|down-regulation of execution phase of apoptosis|downregulation of execution phase of apoptosis|inhibition of execution phase of apoptosis http://purl.obolibrary.org/obo/GO_1900118 GO:0046281 biolink:BiologicalProcess cinnamic acid catabolic process The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid. go.json cinnamic acid breakdown|cinnamic acid catabolism|cinnamic acid degradation|cinnamylic acid catabolic process|cinnamylic acid catabolism|phenylacrylic acid catabolic process|phenylacrylic acid catabolism http://purl.obolibrary.org/obo/GO_0046281 GO:1900117 biolink:BiologicalProcess regulation of execution phase of apoptosis Any process that modulates the frequency, rate or extent of execution phase of apoptosis. go.json http://purl.obolibrary.org/obo/GO_1900117 GO:0046280 biolink:BiologicalProcess chalcone catabolic process The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives. go.json chalcone breakdown|chalcone catabolism|chalcone degradation http://purl.obolibrary.org/obo/GO_0046280 GO:1900119 biolink:BiologicalProcess positive regulation of execution phase of apoptosis Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. go.json activation of execution phase of apoptosis|up regulation of execution phase of apoptosis|up-regulation of execution phase of apoptosis|upregulation of execution phase of apoptosis http://purl.obolibrary.org/obo/GO_1900119 GO:1900114 biolink:BiologicalProcess positive regulation of histone H3-K9 trimethylation Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation. go.json activation of histone H3-K9 trimethylation|up regulation of histone H3-K9 trimethylation|up-regulation of histone H3-K9 trimethylation|upregulation of histone H3-K9 trimethylation http://purl.obolibrary.org/obo/GO_1900114 GO:1900113 biolink:BiologicalProcess negative regulation of histone H3-K9 trimethylation Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation. go.json down regulation of histone H3-K9 trimethylation|down-regulation of histone H3-K9 trimethylation|downregulation of histone H3-K9 trimethylation|inhibition of histone H3-K9 trimethylation http://purl.obolibrary.org/obo/GO_1900113 GO:1900116 biolink:BiologicalProcess extracellular negative regulation of signal transduction Any negative regulation of signal transduction that takes place in extracellular region. go.json down regulation of signal transduction in extracellular region|down-regulation of signal transduction in extracellular region|downregulation of signal transduction in extracellular region|extracellular inhibition of signaling pathway|inhibition of signal transduction in extracellular region|negative regulation of signaling pathway in extracellular region|negative regulation of signalling pathway in extracellular region http://purl.obolibrary.org/obo/GO_1900116 GO:1900115 biolink:BiologicalProcess extracellular regulation of signal transduction Any regulation of signal transduction that takes place in the extracellular region. go.json regulation of signaling pathway in extracellular region|regulation of signalling pathway in extracellular region http://purl.obolibrary.org/obo/GO_1900115 GO:1900110 biolink:BiologicalProcess negative regulation of histone H3-K9 dimethylation Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation. go.json down regulation of histone H3 K9 dimethylation|down regulation of histone H3-K9 dimethylation|down regulation of histone lysine H3 K9 dimethylation|down-regulation of histone H3 K9 dimethylation|down-regulation of histone H3-K9 dimethylation|down-regulation of histone lysine H3 K9 dimethylation|downregulation of histone H3 K9 dimethylation|downregulation of histone H3-K9 dimethylation|downregulation of histone lysine H3 K9 dimethylation|inhibition of histone H3 K9 dimethylation|inhibition of histone H3-K9 dimethylation|inhibition of histone lysine H3 K9 dimethylation|negative regulation of histone H3 K9 dimethylation|negative regulation of histone lysine H3 K9 dimethylation http://purl.obolibrary.org/obo/GO_1900110 GO:0046289 biolink:BiologicalProcess isoflavonoid phytoalexin metabolic process The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. go.json isoflavonoid phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0046289 GO:0046288 biolink:BiologicalProcess isoflavonoid catabolic process The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. go.json isoflavonoid breakdown|isoflavonoid catabolism|isoflavonoid degradation http://purl.obolibrary.org/obo/GO_0046288 GO:1900112 biolink:BiologicalProcess regulation of histone H3-K9 trimethylation Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation. go.json http://purl.obolibrary.org/obo/GO_1900112 GO:1900111 biolink:BiologicalProcess positive regulation of histone H3-K9 dimethylation Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation. go.json activation of histone H3 K9 dimethylation|activation of histone H3-K9 dimethylation|activation of histone lysine H3 K9 dimethylation|positive regulation of histone H3 K9 dimethylation|positive regulation of histone lysine H3 K9 dimethylation|up regulation of histone H3 K9 dimethylation|up regulation of histone H3-K9 dimethylation|up regulation of histone lysine H3 K9 dimethylation|up-regulation of histone H3 K9 dimethylation|up-regulation of histone H3-K9 dimethylation|up-regulation of histone lysine H3 K9 dimethylation|upregulation of histone H3 K9 dimethylation|upregulation of histone H3-K9 dimethylation|upregulation of histone lysine H3 K9 dimethylation http://purl.obolibrary.org/obo/GO_1900111 GO:0046287 biolink:BiologicalProcess isoflavonoid metabolic process The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group. go.json isoflavonoid metabolism http://purl.obolibrary.org/obo/GO_0046287 GO:0071249 biolink:BiologicalProcess cellular response to nitrate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus. go.json http://purl.obolibrary.org/obo/GO_0071249 GO:0071248 biolink:BiologicalProcess cellular response to metal ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. go.json cellular response to heavy metal|cellular response to metal http://purl.obolibrary.org/obo/GO_0071248 GO:0071247 biolink:BiologicalProcess cellular response to chromate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. go.json http://purl.obolibrary.org/obo/GO_0071247 GO:0071246 biolink:BiologicalProcess cellular response to chlorate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus. go.json http://purl.obolibrary.org/obo/GO_0071246 GO:0071245 biolink:BiologicalProcess cellular response to carbon monoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus. go.json http://purl.obolibrary.org/obo/GO_0071245 GO:0071244 biolink:BiologicalProcess cellular response to carbon dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0071244 GO:0071243 biolink:BiologicalProcess cellular response to arsenic-containing substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. go.json cellular response to arsenic http://purl.obolibrary.org/obo/GO_0071243 GO:0046297 biolink:BiologicalProcess obsolete 2,4-dichlorobenzoate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). go.json 2,4-dichlorobenzoate anabolism|2,4-dichlorobenzoate biosynthesis|2,4-dichlorobenzoate biosynthetic process|2,4-dichlorobenzoate formation|2,4-dichlorobenzoate synthesis True http://purl.obolibrary.org/obo/GO_0046297 GO:0071231 biolink:BiologicalProcess cellular response to folic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. go.json response to folate|response to vitamin B9 http://purl.obolibrary.org/obo/GO_0071231 GO:0071230 biolink:BiologicalProcess cellular response to amino acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. go.json cellular response to amino acid http://purl.obolibrary.org/obo/GO_0071230 GO:0046296 biolink:BiologicalProcess glycolate catabolic process The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid). go.json glycolate breakdown|glycolate catabolism|glycolate degradation http://purl.obolibrary.org/obo/GO_0046296 GO:0046295 biolink:BiologicalProcess glycolate biosynthetic process The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid). go.json glycolate anabolism|glycolate biosynthesis|glycolate formation|glycolate synthesis http://purl.obolibrary.org/obo/GO_0046295 GO:0046294 biolink:BiologicalProcess formaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. go.json formaldehyde breakdown|formaldehyde catabolism|formaldehyde degradation|methanal catabolic process|methanal catabolism http://purl.obolibrary.org/obo/GO_0046294 GO:1900129 biolink:BiologicalProcess positive regulation of G-protein activated inward rectifier potassium channel activity Any process that activates or increases the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity. go.json activation of G protein activated inward rectifier potassium channel activity|activation of G protein enhanced inward rectifier potassium channel activity|activation of G-protein activated inward rectifier potassium channel activity|activation of G-protein enhanced inward rectifier potassium channel activity|activation of G-protein-activated inward rectifier potassium channel activity|activation of G-protein-enhanced inward rectifier potassium channel activity|positive regulation of G protein activated inward rectifier potassium channel activity|positive regulation of G protein enhanced inward rectifier potassium channel activity|positive regulation of G-protein enhanced inward rectifier potassium channel activity|positive regulation of G-protein-activated inward rectifier potassium channel activity|positive regulation of G-protein-enhanced inward rectifier potassium channel activity|up regulation of G protein activated inward rectifier potassium channel activity|up regulation of G protein enhanced inward rectifier potassium channel activity|up regulation of G-protein activated inward rectifier potassium channel activity|up regulation of G-protein enhanced inward rectifier potassium channel activity|up regulation of G-protein-activated inward rectifier potassium channel activity|up regulation of G-protein-enhanced inward rectifier potassium channel activity|up-regulation of G protein activated inward rectifier potassium channel activity|up-regulation of G protein enhanced inward rectifier potassium channel activity|up-regulation of G-protein activated inward rectifier potassium channel activity|up-regulation of G-protein enhanced inward rectifier potassium channel activity|up-regulation of G-protein-activated inward rectifier potassium channel activity|up-regulation of G-protein-enhanced inward rectifier potassium channel activity|upregulation of G protein activated inward rectifier potassium channel activity|upregulation of G protein enhanced inward rectifier potassium channel activity|upregulation of G-protein activated inward rectifier potassium channel activity|upregulation of G-protein enhanced inward rectifier potassium channel activity|upregulation of G-protein-activated inward rectifier potassium channel activity|upregulation of G-protein-enhanced inward rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_1900129 gocheck_do_not_annotate GO:0046293 biolink:BiologicalProcess formaldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde. go.json formaldehyde anabolism|formaldehyde biosynthesis|formaldehyde formation|formaldehyde synthesis|methanal biosynthesis|methanal biosynthetic process http://purl.obolibrary.org/obo/GO_0046293 GO:1900128 biolink:BiologicalProcess regulation of G-protein activated inward rectifier potassium channel activity Any process that modulates the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity. go.json regulation of G protein activated inward rectifier potassium channel activity|regulation of G protein enhanced inward rectifier potassium channel activity|regulation of G-protein enhanced inward rectifier potassium channel activity|regulation of G-protein-activated inward rectifier potassium channel activity|regulation of G-protein-enhanced inward rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_1900128 gocheck_do_not_annotate GO:0046292 biolink:BiologicalProcess formaldehyde metabolic process The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent. go.json formaldehyde metabolism|methanal metabolic process|methanal metabolism http://purl.obolibrary.org/obo/GO_0046292 GO:0046291 biolink:BiologicalProcess obsolete 6-hydroxycineole biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. go.json 6-endo-hydroxycineole biosynthesis|6-endo-hydroxycineole biosynthetic process|6-hydroxycineole anabolism|6-hydroxycineole biosynthesis|6-hydroxycineole biosynthetic process|6-hydroxycineole formation|6-hydroxycineole synthesis|hydroxycineol biosynthesis|hydroxycineol biosynthetic process True http://purl.obolibrary.org/obo/GO_0046291 GO:0046290 biolink:BiologicalProcess isoflavonoid phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. go.json isoflavonoid phytoalexin breakdown|isoflavonoid phytoalexin catabolism|isoflavonoid phytoalexin degradation http://purl.obolibrary.org/obo/GO_0046290 GO:1900125 biolink:BiologicalProcess regulation of hyaluronan biosynthetic process Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. go.json regulation of hyaluronan anabolism|regulation of hyaluronan biosynthesis|regulation of hyaluronan formation|regulation of hyaluronan synthesis http://purl.obolibrary.org/obo/GO_1900125 GO:1900124 biolink:BiologicalProcess negative regulation of nodal receptor complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of nodal receptor complex assembly. go.json down regulation of ActRIIB.ALK4.EGF-CFC complex formation|down regulation of nodal receptor complex assembly|down regulation of nodal receptor complex formation|down-regulation of ActRIIB.ALK4.EGF-CFC complex formation|down-regulation of nodal receptor complex assembly|down-regulation of nodal receptor complex formation|downregulation of ActRIIB.ALK4.EGF-CFC complex formation|downregulation of nodal receptor complex assembly|downregulation of nodal receptor complex formation|inhibition of ActRIIB.ALK4.EGF-CFC complex formation|inhibition of nodal receptor complex assembly|inhibition of nodal receptor complex formation|negative regulation of ActRIIB.ALK4.EGF-CFC complex formation|negative regulation of nodal receptor complex formation http://purl.obolibrary.org/obo/GO_1900124 GO:1900127 biolink:BiologicalProcess positive regulation of hyaluronan biosynthetic process Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. go.json activation of hyaluronan anabolism|activation of hyaluronan biosynthesis|activation of hyaluronan biosynthetic process|activation of hyaluronan formation|activation of hyaluronan synthesis|positive regulation of hyaluronan anabolism|positive regulation of hyaluronan biosynthesis|positive regulation of hyaluronan formation|positive regulation of hyaluronan synthesis|up regulation of hyaluronan anabolism|up regulation of hyaluronan biosynthesis|up regulation of hyaluronan biosynthetic process|up regulation of hyaluronan formation|up regulation of hyaluronan synthesis|up-regulation of hyaluronan anabolism|up-regulation of hyaluronan biosynthesis|up-regulation of hyaluronan biosynthetic process|up-regulation of hyaluronan formation|up-regulation of hyaluronan synthesis|upregulation of hyaluronan anabolism|upregulation of hyaluronan biosynthesis|upregulation of hyaluronan biosynthetic process|upregulation of hyaluronan formation|upregulation of hyaluronan synthesis http://purl.obolibrary.org/obo/GO_1900127 GO:1900126 biolink:BiologicalProcess negative regulation of hyaluronan biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. go.json down regulation of hyaluronan anabolism|down regulation of hyaluronan biosynthesis|down regulation of hyaluronan biosynthetic process|down regulation of hyaluronan formation|down regulation of hyaluronan synthesis|down-regulation of hyaluronan anabolism|down-regulation of hyaluronan biosynthesis|down-regulation of hyaluronan biosynthetic process|down-regulation of hyaluronan formation|down-regulation of hyaluronan synthesis|downregulation of hyaluronan anabolism|downregulation of hyaluronan biosynthesis|downregulation of hyaluronan biosynthetic process|downregulation of hyaluronan formation|downregulation of hyaluronan synthesis|inhibition of hyaluronan anabolism|inhibition of hyaluronan biosynthesis|inhibition of hyaluronan biosynthetic process|inhibition of hyaluronan formation|inhibition of hyaluronan synthesis|negative regulation of hyaluronan anabolism|negative regulation of hyaluronan biosynthesis|negative regulation of hyaluronan formation|negative regulation of hyaluronan synthesis http://purl.obolibrary.org/obo/GO_1900126 GO:1900121 biolink:BiologicalProcess negative regulation of receptor binding Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. go.json down regulation of receptor binding|down regulation of receptor-associated protein activity|down-regulation of receptor binding|downregulation of receptor binding|inhibition of receptor binding|inhibition of receptor ligand http://purl.obolibrary.org/obo/GO_1900121 gocheck_do_not_annotate GO:1900120 biolink:BiologicalProcess regulation of receptor binding Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. go.json regulation of receptor ligand http://purl.obolibrary.org/obo/GO_1900120 gocheck_do_not_annotate GO:0046299 biolink:BiologicalProcess obsolete 2,4-dichlorophenoxyacetic acid biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. go.json 2,4-dichlorophenoxyacetic acid anabolism|2,4-dichlorophenoxyacetic acid biosynthesis|2,4-dichlorophenoxyacetic acid biosynthetic process|2,4-dichlorophenoxyacetic acid formation|2,4-dichlorophenoxyacetic acid synthesis True http://purl.obolibrary.org/obo/GO_0046299 GO:1900123 biolink:BiologicalProcess regulation of nodal receptor complex assembly Any process that modulates the frequency, rate or extent of nodal receptor complex assembly. go.json regulation of ActRIIB.ALK4.EGF-CFC complex formation|regulation of nodal receptor complex formation http://purl.obolibrary.org/obo/GO_1900123 GO:1900122 biolink:BiologicalProcess positive regulation of receptor binding Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor. go.json activation of receptor binding|up regulation of receptor binding|upregulation of receptor binding http://purl.obolibrary.org/obo/GO_1900122 gocheck_do_not_annotate GO:0046298 biolink:BiologicalProcess 2,4-dichlorobenzoate catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). go.json 2,4-dichlorobenzoate breakdown|2,4-dichlorobenzoate catabolism|2,4-dichlorobenzoate degradation http://purl.obolibrary.org/obo/GO_0046298 GO:1900130 biolink:BiologicalProcess regulation of lipid binding Any process that modulates the frequency, rate or extent of lipid binding. go.json http://purl.obolibrary.org/obo/GO_1900130 gocheck_do_not_annotate GO:0071239 biolink:BiologicalProcess cellular response to streptomycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. go.json http://purl.obolibrary.org/obo/GO_0071239 GO:0071238 biolink:BiologicalProcess cellular response to brefeldin A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. go.json http://purl.obolibrary.org/obo/GO_0071238 GO:0071237 biolink:BiologicalProcess cellular response to bacteriocin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation. go.json http://purl.obolibrary.org/obo/GO_0071237 GO:0071236 biolink:BiologicalProcess cellular response to antibiotic Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. go.json http://purl.obolibrary.org/obo/GO_0071236 GO:0071235 biolink:BiologicalProcess cellular response to proline Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus. go.json http://purl.obolibrary.org/obo/GO_0071235 GO:0071234 biolink:BiologicalProcess cellular response to phenylalanine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus. go.json http://purl.obolibrary.org/obo/GO_0071234 GO:0071233 biolink:BiologicalProcess cellular response to leucine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus. go.json http://purl.obolibrary.org/obo/GO_0071233 GO:0071232 biolink:BiologicalProcess cellular response to histidine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus. go.json http://purl.obolibrary.org/obo/GO_0071232 GO:0071264 biolink:BiologicalProcess positive regulation of translational initiation in response to starvation Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment. go.json activation of translation initiation in response to starvation|positive regulation of translational initiation in response to nutrient starvation|stimulation of translation initiation in response to starvation|up regulation of translation initiation in response to starvation|up-regulation of translation initiation in response to starvation|upregulation of translation initiation in response to starvation http://purl.obolibrary.org/obo/GO_0071264 GO:0071263 biolink:BiologicalProcess negative regulation of translational initiation in response to starvation Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment. go.json down regulation of translation initiation in response to starvation|down-regulation of translation initiation in response to starvation|downregulation of translation initiation in response to starvation|inhibition of translation initiation in response to starvation|negative regulation of translational initiation in response to nutrient starvation http://purl.obolibrary.org/obo/GO_0071263 GO:0071262 biolink:BiologicalProcess regulation of translational initiation in response to starvation Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment. go.json regulation of translational initiation in response to nutrient starvation http://purl.obolibrary.org/obo/GO_0071262 GO:0071261 biolink:CellularComponent Ssh1 translocon complex A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences. go.json Ssh1p-Sss1p-Sbh2p complex http://purl.obolibrary.org/obo/GO_0071261 GO:0071260 biolink:BiologicalProcess cellular response to mechanical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. go.json cellular mechanical stimulus response http://purl.obolibrary.org/obo/GO_0071260 GO:1900139 biolink:BiologicalProcess negative regulation of arachidonic acid secretion Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion. go.json down regulation of arachidonic acid secretion|down-regulation of arachidonic acid secretion|downregulation of arachidonic acid secretion|inhibition of arachidonic acid secretion http://purl.obolibrary.org/obo/GO_1900139 GO:1900136 biolink:BiologicalProcess regulation of chemokine activity Any process that modulates the frequency, rate or extent of chemokine activity. go.json http://purl.obolibrary.org/obo/GO_1900136 gocheck_do_not_annotate GO:1900135 biolink:BiologicalProcess positive regulation of renin secretion into blood stream Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream. go.json activation of renin release into blood stream|activation of renin secretion into blood stream|positive regulation of renin release into blood stream|up regulation of renin release into blood stream|up regulation of renin secretion into blood stream|up-regulation of renin release into blood stream|up-regulation of renin secretion into blood stream|upregulation of renin release into blood stream|upregulation of renin secretion into blood stream http://purl.obolibrary.org/obo/GO_1900135 GO:1900138 biolink:BiologicalProcess negative regulation of phospholipase A2 activity Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity. go.json down regulation of cytosolic phospholipase A2 activity|down regulation of lecithinase A activity|down regulation of phosphatidase activity|down regulation of phosphatidolipase activity|down regulation of phosphatidylcholine 2-acylhydrolase activity|down regulation of phospholipase A|down regulation of phospholipase A2 activity|down regulation of secreted phospholipase A2 activity|down-regulation of cytosolic phospholipase A2 activity|down-regulation of lecithinase A activity|down-regulation of phosphatidase activity|down-regulation of phosphatidolipase activity|down-regulation of phosphatidylcholine 2-acylhydrolase activity|down-regulation of phospholipase A|down-regulation of phospholipase A2 activity|down-regulation of secreted phospholipase A2 activity|downregulation of cytosolic phospholipase A2 activity|downregulation of lecithinase A activity|downregulation of phosphatidase activity|downregulation of phosphatidolipase activity|downregulation of phosphatidylcholine 2-acylhydrolase activity|downregulation of phospholipase A|downregulation of phospholipase A2 activity|downregulation of secreted phospholipase A2 activity|inhibition of cytosolic phospholipase A2 activity|inhibition of lecithinase A activity|inhibition of phosphatidase activity|inhibition of phosphatidolipase activity|inhibition of phosphatidylcholine 2-acylhydrolase activity|inhibition of phospholipase A|inhibition of phospholipase A2 activity|inhibition of secreted phospholipase A2 activity|negative regulation of cytosolic phospholipase A2 activity|negative regulation of lecithinase A activity|negative regulation of phosphatidase activity|negative regulation of phosphatidolipase activity|negative regulation of phosphatidylcholine 2-acylhydrolase activity|negative regulation of phospholipase A|negative regulation of secreted phospholipase A2 activity http://purl.obolibrary.org/obo/GO_1900138 gocheck_do_not_annotate GO:1900137 biolink:BiologicalProcess negative regulation of chemokine activity Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity. go.json down regulation of chemokine activity|down-regulation of chemokine activity|downregulation of chemokine activity|inhibition of chemokine activity http://purl.obolibrary.org/obo/GO_1900137 gocheck_do_not_annotate GO:1900132 biolink:BiologicalProcess positive regulation of lipid binding Any process that activates or increases the frequency, rate or extent of lipid binding. go.json activation of lipid binding|up regulation of lipid binding|up-regulation of lipid binding|upregulation of lipid binding http://purl.obolibrary.org/obo/GO_1900132 gocheck_do_not_annotate GO:1900131 biolink:BiologicalProcess negative regulation of lipid binding Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding. go.json down regulation of lipid binding|down-regulation of lipid binding|downregulation of lipid binding|inhibition of lipid binding http://purl.obolibrary.org/obo/GO_1900131 gocheck_do_not_annotate GO:1900134 biolink:BiologicalProcess negative regulation of renin secretion into blood stream Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream. go.json down regulation of renin release into blood stream|down regulation of renin secretion into blood stream|down-regulation of renin release into blood stream|down-regulation of renin secretion into blood stream|downregulation of renin release into blood stream|downregulation of renin secretion into blood stream|inhibition of renin release into blood stream|inhibition of renin secretion into blood stream|negative regulation of renin release into blood stream http://purl.obolibrary.org/obo/GO_1900134 GO:1900133 biolink:BiologicalProcess regulation of renin secretion into blood stream Any process that modulates the frequency, rate or extent of renin secretion into blood stream. go.json regulation of renin release into blood stream http://purl.obolibrary.org/obo/GO_1900133 GO:1900141 biolink:BiologicalProcess regulation of oligodendrocyte apoptotic process Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process. go.json regulation of oligodendrocyte apoptosis http://purl.obolibrary.org/obo/GO_1900141 GO:1900140 biolink:BiologicalProcess regulation of seedling development Any process that modulates the frequency, rate or extent of seedling development. go.json http://purl.obolibrary.org/obo/GO_1900140 GO:0071269 biolink:BiologicalProcess L-homocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid. go.json L-homocysteine anabolism|L-homocysteine biosynthesis|L-homocysteine formation|L-homocysteine synthesis http://purl.obolibrary.org/obo/GO_0071269 GO:0071268 biolink:BiologicalProcess homocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid. go.json homocysteine anabolism|homocysteine biosynthesis|homocysteine formation|homocysteine synthesis http://purl.obolibrary.org/obo/GO_0071268 GO:0071267 biolink:BiologicalProcess L-methionine salvage Any process that generates L-methionine from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0071267 GO:0071266 biolink:BiologicalProcess 'de novo' L-methionine biosynthetic process The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components. go.json 'de novo' L-methionine anabolism|'de novo' L-methionine biosynthesis|'de novo' L-methionine formation|'de novo' L-methionine synthesis http://purl.obolibrary.org/obo/GO_0071266 GO:0071265 biolink:BiologicalProcess L-methionine biosynthetic process The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid. go.json L-methionine anabolism|L-methionine biosynthesis|L-methionine formation|L-methionine synthesis http://purl.obolibrary.org/obo/GO_0071265 GO:0071253 biolink:MolecularActivity connexin binding Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. go.json http://purl.obolibrary.org/obo/GO_0071253 GO:0071252 biolink:BiologicalProcess cellular response to sulfur dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus. go.json http://purl.obolibrary.org/obo/GO_0071252 GO:0071251 biolink:BiologicalProcess cellular response to silicon dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus. go.json cellular response to silica|cellular response to silox http://purl.obolibrary.org/obo/GO_0071251 GO:0071250 biolink:BiologicalProcess cellular response to nitrite Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus. go.json http://purl.obolibrary.org/obo/GO_0071250 GO:1900147 biolink:BiologicalProcess regulation of Schwann cell migration Any process that modulates the frequency, rate or extent of Schwann cell migration. go.json http://purl.obolibrary.org/obo/GO_1900147 GO:1900146 biolink:BiologicalProcess obsolete negative regulation of nodal signaling pathway involved in determination of left/right asymmetry OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry. go.json down regulation of nodal signaling pathway involved in determination of left/right asymmetry|down-regulation of nodal signaling pathway involved in determination of left/right asymmetry|downregulation of nodal signaling pathway involved in determination of left/right asymmetry|inhibition of nodal signaling pathway involved in determination of left/right asymmetry|negative regulation of nodal signalling pathway involved in determination of left/right asymmetry True http://purl.obolibrary.org/obo/GO_1900146 GO:1900149 biolink:BiologicalProcess positive regulation of Schwann cell migration Any process that activates or increases the frequency, rate or extent of Schwann cell migration. go.json activation of Schwann cell migration|up regulation of Schwann cell migration|up-regulation of Schwann cell migration|upregulation of Schwann cell migration http://purl.obolibrary.org/obo/GO_1900149 GO:1900148 biolink:BiologicalProcess negative regulation of Schwann cell migration Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration. go.json down regulation of Schwann cell migration|down-regulation of Schwann cell migration|downregulation of Schwann cell migration|inhibition of Schwann cell migration http://purl.obolibrary.org/obo/GO_1900148 GO:1900143 biolink:BiologicalProcess positive regulation of oligodendrocyte apoptotic process Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process. go.json activation of oligodendrocyte apoptosis|activation of oligodendrocyte apoptotic process|positive regulation of oligodendrocyte apoptosis|up regulation of oligodendrocyte apoptosis|up regulation of oligodendrocyte apoptotic process|up-regulation of oligodendrocyte apoptosis|up-regulation of oligodendrocyte apoptotic process|upregulation of oligodendrocyte apoptosis|upregulation of oligodendrocyte apoptotic process http://purl.obolibrary.org/obo/GO_1900143 GO:1900142 biolink:BiologicalProcess negative regulation of oligodendrocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process. go.json down regulation of oligodendrocyte apoptosis|down regulation of oligodendrocyte apoptotic process|down-regulation of oligodendrocyte apoptosis|down-regulation of oligodendrocyte apoptotic process|downregulation of oligodendrocyte apoptosis|downregulation of oligodendrocyte apoptotic process|inhibition of oligodendrocyte apoptosis|inhibition of oligodendrocyte apoptotic process|negative regulation of oligodendrocyte apoptosis http://purl.obolibrary.org/obo/GO_1900142 GO:1900145 biolink:BiologicalProcess obsolete regulation of nodal signaling pathway involved in determination of left/right asymmetry OBSOLETE. Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry. go.json regulation of nodal signalling pathway involved in determination of left/right asymmetry True http://purl.obolibrary.org/obo/GO_1900145 GO:1900144 biolink:BiologicalProcess positive regulation of BMP secretion Any process that activates or increases the frequency, rate or extent of BMP secretion. go.json activation of BMP protein secretion|activation of BMP secretion|activation of bone morphogenetic protein secretion|positive regulation of BMP protein secretion|positive regulation of bone morphogenetic protein secretion|up regulation of BMP protein secretion|up regulation of BMP secretion|up regulation of bone morphogenetic protein secretion|up-regulation of BMP protein secretion|up-regulation of BMP secretion|up-regulation of bone morphogenetic protein secretion|upregulation of BMP protein secretion|upregulation of BMP secretion|upregulation of bone morphogenetic protein secretion http://purl.obolibrary.org/obo/GO_1900144 GO:1900150 biolink:BiologicalProcess regulation of defense response to fungus Any process that modulates the frequency, rate or extent of defense response to fungus. go.json regulation of defence response to fungi|regulation of defence response to fungus|regulation of defense response to fungi|regulation of defense response to fungi, incompatible interaction|regulation of defense response to fungus, incompatible interaction|regulation of resistance response to pathogenic fungi|regulation of resistance response to pathogenic fungus|regulation of response to pathogenic fungus (incompatible interaction) http://purl.obolibrary.org/obo/GO_1900150 GO:1900152 biolink:BiologicalProcess negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. go.json down regulation of deadenylation-dependent mRNA decay|down regulation of mRNA breakdown, deadenylation-dependent decay|down regulation of mRNA catabolic process, deadenylation-dependent|down regulation of mRNA catabolic process, deadenylylation-dependent|down regulation of mRNA catabolism, deadenylation-dependent|down regulation of mRNA catabolism, deadenylylation-dependent|down regulation of mRNA degradation, deadenylation-dependent decay|down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|down-regulation of deadenylation-dependent mRNA decay|down-regulation of mRNA breakdown, deadenylation-dependent decay|down-regulation of mRNA catabolic process, deadenylation-dependent|down-regulation of mRNA catabolic process, deadenylylation-dependent|down-regulation of mRNA catabolism, deadenylation-dependent|down-regulation of mRNA catabolism, deadenylylation-dependent|down-regulation of mRNA degradation, deadenylation-dependent decay|down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|downregulation of deadenylation-dependent mRNA decay|downregulation of mRNA breakdown, deadenylation-dependent decay|downregulation of mRNA catabolic process, deadenylation-dependent|downregulation of mRNA catabolic process, deadenylylation-dependent|downregulation of mRNA catabolism, deadenylation-dependent|downregulation of mRNA catabolism, deadenylylation-dependent|downregulation of mRNA degradation, deadenylation-dependent decay|downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay|downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|inhibition of deadenylation-dependent mRNA decay|inhibition of mRNA breakdown, deadenylation-dependent decay|inhibition of mRNA catabolic process, deadenylation-dependent|inhibition of mRNA catabolic process, deadenylylation-dependent|inhibition of mRNA catabolism, deadenylation-dependent|inhibition of mRNA catabolism, deadenylylation-dependent|inhibition of mRNA degradation, deadenylation-dependent decay|inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay|inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of deadenylation-dependent mRNA decay|negative regulation of mRNA breakdown, deadenylation-dependent decay|negative regulation of mRNA catabolic process, deadenylation-dependent|negative regulation of mRNA catabolic process, deadenylylation-dependent|negative regulation of mRNA catabolism, deadenylation-dependent|negative regulation of mRNA catabolism, deadenylylation-dependent|negative regulation of mRNA degradation, deadenylation-dependent decay|negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay http://purl.obolibrary.org/obo/GO_1900152 GO:1900151 biolink:BiologicalProcess regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. go.json regulation of deadenylation-dependent mRNA decay|regulation of mRNA breakdown, deadenylation-dependent decay|regulation of mRNA catabolic process, deadenylation-dependent|regulation of mRNA catabolic process, deadenylylation-dependent|regulation of mRNA catabolism, deadenylation-dependent|regulation of mRNA catabolism, deadenylylation-dependent|regulation of mRNA degradation, deadenylation-dependent decay|regulation of nuclear mRNA catabolic process, deadenylation-dependent decay http://purl.obolibrary.org/obo/GO_1900151 GO:0071259 biolink:BiologicalProcess cellular response to magnetism Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. go.json cellular response to magnetic stimulus http://purl.obolibrary.org/obo/GO_0071259 GO:0071258 biolink:BiologicalProcess cellular response to gravity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. go.json cellular response to gravitational stimulus http://purl.obolibrary.org/obo/GO_0071258 GO:0071257 biolink:BiologicalProcess cellular response to electrical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. go.json cellular response to electricity http://purl.obolibrary.org/obo/GO_0071257 GO:0071256 biolink:CellularComponent translocon complex A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. go.json Sec complex-associated translocon complex http://purl.obolibrary.org/obo/GO_0071256 goslim_pir GO:0071255 biolink:BiologicalProcess Cvt vesicle assembly A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI). go.json Cvt vesicle biosynthesis|Cvt vesicle formation|cytoplasm to vacuole targeting vesicle assembly|cytoplasm-to-vacuole targetin vesicle assembly http://purl.obolibrary.org/obo/GO_0071255 GO:0071254 biolink:CellularComponent cytoplasmic U snRNP body A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies. go.json U body|U-body http://purl.obolibrary.org/obo/GO_0071254 GO:0071286 biolink:BiologicalProcess cellular response to magnesium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0071286 GO:0071285 biolink:BiologicalProcess cellular response to lithium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0071285 GO:0071284 biolink:BiologicalProcess cellular response to lead ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0071284 GO:0071283 biolink:BiologicalProcess cellular response to iron(III) ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. go.json cellular response to iron(III) http://purl.obolibrary.org/obo/GO_0071283 GO:0071282 biolink:BiologicalProcess cellular response to iron(II) ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. go.json cellular response to iron(II) http://purl.obolibrary.org/obo/GO_0071282 GO:0071281 biolink:BiologicalProcess cellular response to iron ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. go.json cellular response to iron http://purl.obolibrary.org/obo/GO_0071281 GO:0071280 biolink:BiologicalProcess cellular response to copper ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. go.json cellular response to copper http://purl.obolibrary.org/obo/GO_0071280 GO:1900158 biolink:BiologicalProcess negative regulation of bone mineralization involved in bone maturation Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation. go.json down regulation of bone mineralization involved in bone maturation|down-regulation of bone mineralization involved in bone maturation|downregulation of bone mineralization involved in bone maturation|inhibition of bone mineralization involved in bone maturation http://purl.obolibrary.org/obo/GO_1900158 GO:1900157 biolink:BiologicalProcess regulation of bone mineralization involved in bone maturation Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation. go.json http://purl.obolibrary.org/obo/GO_1900157 GO:1900159 biolink:BiologicalProcess positive regulation of bone mineralization involved in bone maturation Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation. go.json activation of bone mineralization involved in bone maturation|up regulation of bone mineralization involved in bone maturation|up-regulation of bone mineralization involved in bone maturation|upregulation of bone mineralization involved in bone maturation http://purl.obolibrary.org/obo/GO_1900159 GO:1900154 biolink:BiologicalProcess regulation of bone trabecula formation Any process that modulates the frequency, rate or extent of bone trabecula formation. go.json regulation of bone trabecula biogenesis|regulation of bone trabeculation|regulation of skeletal trabecula biogenesis|regulation of skeletal trabecula formation|regulation of skeletal trabeculation http://purl.obolibrary.org/obo/GO_1900154 GO:1900153 biolink:BiologicalProcess positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. go.json activation of deadenylation-dependent mRNA decay|activation of mRNA breakdown, deadenylation-dependent decay|activation of mRNA catabolic process, deadenylation-dependent|activation of mRNA catabolic process, deadenylylation-dependent|activation of mRNA catabolism, deadenylation-dependent|activation of mRNA catabolism, deadenylylation-dependent|activation of mRNA degradation, deadenylation-dependent decay|activation of nuclear mRNA catabolic process, deadenylation-dependent decay|activation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of deadenylation-dependent mRNA decay|positive regulation of mRNA breakdown, deadenylation-dependent decay|positive regulation of mRNA catabolic process, deadenylation-dependent|positive regulation of mRNA catabolic process, deadenylylation-dependent|positive regulation of mRNA catabolism, deadenylation-dependent|positive regulation of mRNA catabolism, deadenylylation-dependent|positive regulation of mRNA degradation, deadenylation-dependent decay|positive regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|up regulation of deadenylation-dependent mRNA decay|up regulation of mRNA breakdown, deadenylation-dependent decay|up regulation of mRNA catabolic process, deadenylation-dependent|up regulation of mRNA catabolic process, deadenylylation-dependent|up regulation of mRNA catabolism, deadenylation-dependent|up regulation of mRNA catabolism, deadenylylation-dependent|up regulation of mRNA degradation, deadenylation-dependent decay|up regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|up regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|up-regulation of deadenylation-dependent mRNA decay|up-regulation of mRNA breakdown, deadenylation-dependent decay|up-regulation of mRNA catabolic process, deadenylation-dependent|up-regulation of mRNA catabolic process, deadenylylation-dependent|up-regulation of mRNA catabolism, deadenylation-dependent|up-regulation of mRNA catabolism, deadenylylation-dependent|up-regulation of mRNA degradation, deadenylation-dependent decay|up-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|up-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|upregulation of deadenylation-dependent mRNA decay|upregulation of mRNA breakdown, deadenylation-dependent decay|upregulation of mRNA catabolic process, deadenylation-dependent|upregulation of mRNA catabolic process, deadenylylation-dependent|upregulation of mRNA catabolism, deadenylation-dependent|upregulation of mRNA catabolism, deadenylylation-dependent|upregulation of mRNA degradation, deadenylation-dependent decay|upregulation of nuclear mRNA catabolic process, deadenylation-dependent decay|upregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay http://purl.obolibrary.org/obo/GO_1900153 GO:1900156 biolink:BiologicalProcess positive regulation of bone trabecula formation Any process that activates or increases the frequency, rate or extent of bone trabecula formation. go.json activation of bone trabecula biogenesis|activation of bone trabecula formation|activation of bone trabeculation|activation of skeletal trabecula biogenesis|activation of skeletal trabecula formation|activation of skeletal trabeculation|positive regulation of bone trabecula biogenesis|positive regulation of bone trabeculation|positive regulation of skeletal trabecula biogenesis|positive regulation of skeletal trabecula formation|positive regulation of skeletal trabeculation|up regulation of bone trabecula biogenesis|up regulation of bone trabecula formation|up regulation of bone trabeculation|up regulation of skeletal trabecula biogenesis|up regulation of skeletal trabecula formation|up regulation of skeletal trabeculation|up-regulation of bone trabecula biogenesis|up-regulation of bone trabecula formation|up-regulation of bone trabeculation|up-regulation of skeletal trabecula biogenesis|up-regulation of skeletal trabecula formation|up-regulation of skeletal trabeculation|upregulation of bone trabecula biogenesis|upregulation of bone trabecula formation|upregulation of bone trabeculation|upregulation of skeletal trabecula biogenesis|upregulation of skeletal trabecula formation|upregulation of skeletal trabeculation http://purl.obolibrary.org/obo/GO_1900156 GO:1900155 biolink:BiologicalProcess negative regulation of bone trabecula formation Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation. go.json down regulation of bone trabecula biogenesis|down regulation of bone trabecula formation|down regulation of bone trabeculation|down regulation of skeletal trabecula biogenesis|down regulation of skeletal trabecula formation|down regulation of skeletal trabeculation|down-regulation of bone trabecula biogenesis|down-regulation of bone trabecula formation|down-regulation of bone trabeculation|down-regulation of skeletal trabecula biogenesis|down-regulation of skeletal trabecula formation|down-regulation of skeletal trabeculation|downregulation of bone trabecula biogenesis|downregulation of bone trabecula formation|downregulation of bone trabeculation|downregulation of skeletal trabecula biogenesis|downregulation of skeletal trabecula formation|downregulation of skeletal trabeculation|inhibition of bone trabecula biogenesis|inhibition of bone trabecula formation|inhibition of bone trabeculation|inhibition of skeletal trabecula biogenesis|inhibition of skeletal trabecula formation|inhibition of skeletal trabeculation|negative regulation of bone trabecula biogenesis|negative regulation of bone trabeculation|negative regulation of skeletal trabecula biogenesis|negative regulation of skeletal trabecula formation|negative regulation of skeletal trabeculation http://purl.obolibrary.org/obo/GO_1900155 GO:1900161 biolink:BiologicalProcess regulation of phospholipid scramblase activity Any process that modulates the frequency, rate or extent of phospholipid scramblase activity. go.json http://purl.obolibrary.org/obo/GO_1900161 gocheck_do_not_annotate GO:1900160 biolink:BiologicalProcess plastid chromosome packaging A process in which plastidial DNA and associated proteins organize into a compact, orderly structure. go.json DNA organisation in plastid|DNA organization in plastid|plastid DNA packaging|plastidial DNA packaging http://purl.obolibrary.org/obo/GO_1900160 GO:1900163 biolink:BiologicalProcess positive regulation of phospholipid scramblase activity Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity. go.json activation of phospholipid scramblase activity|up regulation of phospholipid scramblase activity|up-regulation of phospholipid scramblase activity|upregulation of phospholipid scramblase activity http://purl.obolibrary.org/obo/GO_1900163 gocheck_do_not_annotate GO:1900162 biolink:BiologicalProcess negative regulation of phospholipid scramblase activity Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity. go.json down regulation of phospholipid scramblase activity|down-regulation of phospholipid scramblase activity|downregulation of phospholipid scramblase activity|inhibition of phospholipid scramblase activity http://purl.obolibrary.org/obo/GO_1900162 gocheck_do_not_annotate GO:0071289 biolink:BiologicalProcess cellular response to nickel ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus. go.json cellular response to nickel http://purl.obolibrary.org/obo/GO_0071289 GO:0071288 biolink:BiologicalProcess cellular response to mercury ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. go.json cellular response to mercuric ion|cellular response to mercury http://purl.obolibrary.org/obo/GO_0071288 GO:0071287 biolink:BiologicalProcess cellular response to manganese ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. go.json cellular response to manganese http://purl.obolibrary.org/obo/GO_0071287 GO:0071275 biolink:BiologicalProcess cellular response to aluminum ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. go.json cellular response to aluminium ion|cellular response to aluminum http://purl.obolibrary.org/obo/GO_0071275 GO:0071274 biolink:BiologicalProcess isoquinoline alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. go.json ipecac alkaloid catabolism|isoquinoline alkaloid breakdown|isoquinoline alkaloid catabolism|isoquinoline alkaloid degradation http://purl.obolibrary.org/obo/GO_0071274 GO:0071273 biolink:BiologicalProcess morphine catabolic process The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum. go.json morphine breakdown|morphine catabolism|morphine degradation http://purl.obolibrary.org/obo/GO_0071273 GO:0071272 biolink:BiologicalProcess morphine metabolic process The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum. Wikipedia:Morphine go.json morphine metabolism http://purl.obolibrary.org/obo/GO_0071272 GO:0071271 biolink:BiologicalProcess 1-butanol biosynthetic process The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O. go.json 1-butanol anabolism|1-butanol biosynthesis|1-butanol formation|1-butanol synthesis|butan-1-ol biosynthetic process|butanol biosynthetic process http://purl.obolibrary.org/obo/GO_0071271 GO:0071270 biolink:BiologicalProcess 1-butanol metabolic process The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O. go.json 1-butanol metabolism|butan-1-ol metabolic process|butanol metabolic process http://purl.obolibrary.org/obo/GO_0071270 GO:1900169 biolink:BiologicalProcess regulation of glucocorticoid mediated signaling pathway Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway. go.json regulation of glucocorticoid mediated signalling http://purl.obolibrary.org/obo/GO_1900169 GO:1900168 biolink:BiologicalProcess positive regulation of glial cell-derived neurotrophic factor production Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor production. go.json activation of glial cell line-derived neurotrophic factor secretion|positive regulation of GDNF production|positive regulation of glial cell line-derived neurotrophic factor secretion|positive regulation of glial cell-derived neurotrophic factor secretion http://purl.obolibrary.org/obo/GO_1900168 GO:1900165 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900165 GO:1900164 biolink:BiologicalProcess obsolete nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. The series of molecular signals initiated by a nodal protein binding to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves. go.json nodal signaling of determination of left/right asymmetry in lateral mesoderm|nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_1900164 GO:1900167 biolink:BiologicalProcess negative regulation of glial cell-derived neurotrophic factor production Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor production. go.json inhibition of GDNF secretion|inhibition of glial cell line-derived neurotrophic factor secretion|negative regulation of GDNF secretion|negative regulation of glial cell line-derived neurotrophic factor secretion|negative regulation of glial cell-derived neurotrophic factor secretion http://purl.obolibrary.org/obo/GO_1900167 GO:1900166 biolink:BiologicalProcess regulation of glial cell-derived neurotrophic factor production Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor production. go.json regulation of GDNF secretion|regulation of glial cell line-derived neurotrophic factor secretion|regulation of glial cell-derived neurotrophic factor secretion http://purl.obolibrary.org/obo/GO_1900166 GO:1900172 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900172 GO:1900171 biolink:BiologicalProcess positive regulation of glucocorticoid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway. go.json activation of glucocorticoid mediated signaling pathway|activation of glucocorticoid mediated signalling|positive regulation of glucocorticoid mediated signalling|up regulation of glucocorticoid mediated signaling pathway|up regulation of glucocorticoid mediated signalling|up-regulation of glucocorticoid mediated signaling pathway|up-regulation of glucocorticoid mediated signalling|upregulation of glucocorticoid mediated signaling pathway|upregulation of glucocorticoid mediated signalling http://purl.obolibrary.org/obo/GO_1900171 GO:1900174 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900174 GO:1900173 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900173 GO:1900170 biolink:BiologicalProcess negative regulation of glucocorticoid mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway. go.json down regulation of glucocorticoid mediated signaling pathway|down regulation of glucocorticoid mediated signalling|down-regulation of glucocorticoid mediated signaling pathway|down-regulation of glucocorticoid mediated signalling|downregulation of glucocorticoid mediated signaling pathway|downregulation of glucocorticoid mediated signalling|inhibition of glucocorticoid mediated signaling pathway|inhibition of glucocorticoid mediated signalling|negative regulation of glucocorticoid mediated signalling http://purl.obolibrary.org/obo/GO_1900170 GO:0071279 biolink:BiologicalProcess cellular response to cobalt ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0071279 GO:0071278 biolink:BiologicalProcess cellular response to cesium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. go.json cellular response to cesium http://purl.obolibrary.org/obo/GO_0071278 GO:0071277 biolink:BiologicalProcess cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. go.json cellular response to Ca2+ ion http://purl.obolibrary.org/obo/GO_0071277 GO:0071276 biolink:BiologicalProcess cellular response to cadmium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. go.json cellular response to cadmium http://purl.obolibrary.org/obo/GO_0071276 GO:1900179 biolink:BiologicalProcess positive regulation of aflatoxin biosynthetic process Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process. go.json activation of aflatoxin anabolism|activation of aflatoxin biosynthesis|activation of aflatoxin biosynthetic process|activation of aflatoxin formation|activation of aflatoxin synthesis|positive regulation of aflatoxin anabolism|positive regulation of aflatoxin biosynthesis|positive regulation of aflatoxin formation|positive regulation of aflatoxin synthesis|up regulation of aflatoxin anabolism|up regulation of aflatoxin biosynthesis|up regulation of aflatoxin biosynthetic process|up regulation of aflatoxin formation|up regulation of aflatoxin synthesis|up-regulation of aflatoxin anabolism|up-regulation of aflatoxin biosynthesis|up-regulation of aflatoxin biosynthetic process|up-regulation of aflatoxin formation|up-regulation of aflatoxin synthesis|upregulation of aflatoxin anabolism|upregulation of aflatoxin biosynthesis|upregulation of aflatoxin biosynthetic process|upregulation of aflatoxin formation|upregulation of aflatoxin synthesis http://purl.obolibrary.org/obo/GO_1900179 GO:1900176 biolink:BiologicalProcess obsolete negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm. go.json down-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|downregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|inhibition of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_1900176 GO:1900175 biolink:BiologicalProcess obsolete regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry OBSOLETE. Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm. go.json regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry True http://purl.obolibrary.org/obo/GO_1900175 GO:1900178 biolink:BiologicalProcess negative regulation of aflatoxin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of aflatoxin biosynthetic process. go.json down regulation of aflatoxin anabolism|down regulation of aflatoxin biosynthesis|down regulation of aflatoxin biosynthetic process|down regulation of aflatoxin formation|down regulation of aflatoxin synthesis|down-regulation of aflatoxin anabolism|down-regulation of aflatoxin biosynthesis|down-regulation of aflatoxin biosynthetic process|down-regulation of aflatoxin formation|down-regulation of aflatoxin synthesis|downregulation of aflatoxin anabolism|downregulation of aflatoxin biosynthesis|downregulation of aflatoxin biosynthetic process|downregulation of aflatoxin formation|downregulation of aflatoxin synthesis|inhibition of aflatoxin anabolism|inhibition of aflatoxin biosynthesis|inhibition of aflatoxin biosynthetic process|inhibition of aflatoxin formation|inhibition of aflatoxin synthesis|negative regulation of aflatoxin anabolism|negative regulation of aflatoxin biosynthesis|negative regulation of aflatoxin formation|negative regulation of aflatoxin synthesis http://purl.obolibrary.org/obo/GO_1900178 GO:1900177 biolink:BiologicalProcess regulation of aflatoxin biosynthetic process Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process. go.json regulation of aflatoxin anabolism|regulation of aflatoxin biosynthesis|regulation of aflatoxin formation|regulation of aflatoxin synthesis http://purl.obolibrary.org/obo/GO_1900177 GO:1900183 biolink:BiologicalProcess regulation of xanthone-containing compound biosynthetic process Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process. go.json regulation of xanthone biosynthesis|regulation of xanthone biosynthetic process|regulation of xanthone-containing compound anabolism|regulation of xanthone-containing compound biosynthesis|regulation of xanthone-containing compound formation|regulation of xanthone-containing compound synthesis http://purl.obolibrary.org/obo/GO_1900183 GO:1900182 biolink:BiologicalProcess positive regulation of protein localization to nucleus Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. go.json activation of protein localisation to nucleus|activation of protein localization in cell nucleus|activation of protein localization in nucleus|activation of protein localization to nucleus|positive regulation of protein localisation to nucleus|positive regulation of protein localization in cell nucleus|positive regulation of protein localization in nucleus|up regulation of protein localisation to nucleus|up regulation of protein localization in cell nucleus|up regulation of protein localization in nucleus|up regulation of protein localization to nucleus|up-regulation of protein localisation to nucleus|up-regulation of protein localization in cell nucleus|up-regulation of protein localization in nucleus|up-regulation of protein localization to nucleus|upregulation of protein localisation to nucleus|upregulation of protein localization in cell nucleus|upregulation of protein localization in nucleus|upregulation of protein localization to nucleus http://purl.obolibrary.org/obo/GO_1900182 GO:1900185 biolink:BiologicalProcess positive regulation of xanthone-containing compound biosynthetic process Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process. go.json activation of xanthone biosynthesis|activation of xanthone biosynthetic process|activation of xanthone-containing compound anabolism|activation of xanthone-containing compound biosynthesis|activation of xanthone-containing compound biosynthetic process|activation of xanthone-containing compound formation|activation of xanthone-containing compound synthesis|positive regulation of xanthone biosynthesis|positive regulation of xanthone biosynthetic process|positive regulation of xanthone-containing compound anabolism|positive regulation of xanthone-containing compound biosynthesis|positive regulation of xanthone-containing compound formation|positive regulation of xanthone-containing compound synthesis|up regulation of xanthone biosynthesis|up regulation of xanthone biosynthetic process|up regulation of xanthone-containing compound anabolism|up regulation of xanthone-containing compound biosynthesis|up regulation of xanthone-containing compound biosynthetic process|up regulation of xanthone-containing compound formation|up regulation of xanthone-containing compound synthesis|up-regulation of xanthone biosynthesis|up-regulation of xanthone biosynthetic process|up-regulation of xanthone-containing compound anabolism|up-regulation of xanthone-containing compound biosynthesis|up-regulation of xanthone-containing compound biosynthetic process|up-regulation of xanthone-containing compound formation|up-regulation of xanthone-containing compound synthesis|upregulation of xanthone biosynthesis|upregulation of xanthone biosynthetic process|upregulation of xanthone-containing compound anabolism|upregulation of xanthone-containing compound biosynthesis|upregulation of xanthone-containing compound biosynthetic process|upregulation of xanthone-containing compound formation|upregulation of xanthone-containing compound synthesis http://purl.obolibrary.org/obo/GO_1900185 GO:1900184 biolink:BiologicalProcess negative regulation of xanthone-containing compound biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of xanthone-containing compound biosynthetic process. go.json down regulation of xanthone biosynthesis|down regulation of xanthone biosynthetic process|down regulation of xanthone-containing compound anabolism|down regulation of xanthone-containing compound biosynthesis|down regulation of xanthone-containing compound biosynthetic process|down regulation of xanthone-containing compound formation|down regulation of xanthone-containing compound synthesis|down-regulation of xanthone biosynthesis|down-regulation of xanthone biosynthetic process|down-regulation of xanthone-containing compound anabolism|down-regulation of xanthone-containing compound biosynthesis|down-regulation of xanthone-containing compound biosynthetic process|down-regulation of xanthone-containing compound formation|down-regulation of xanthone-containing compound synthesis|downregulation of xanthone biosynthesis|downregulation of xanthone biosynthetic process|downregulation of xanthone-containing compound anabolism|downregulation of xanthone-containing compound biosynthesis|downregulation of xanthone-containing compound biosynthetic process|downregulation of xanthone-containing compound formation|downregulation of xanthone-containing compound synthesis|inhibition of xanthone biosynthesis|inhibition of xanthone biosynthetic process|inhibition of xanthone-containing compound anabolism|inhibition of xanthone-containing compound biosynthesis|inhibition of xanthone-containing compound biosynthetic process|inhibition of xanthone-containing compound formation|inhibition of xanthone-containing compound synthesis|negative regulation of xanthone biosynthesis|negative regulation of xanthone biosynthetic process|negative regulation of xanthone-containing compound anabolism|negative regulation of xanthone-containing compound biosynthesis|negative regulation of xanthone-containing compound formation|negative regulation of xanthone-containing compound synthesis|negative regulation of xanthones anabolism http://purl.obolibrary.org/obo/GO_1900184 GO:1900181 biolink:BiologicalProcess negative regulation of protein localization to nucleus Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. go.json down regulation of protein localisation to nucleus|down regulation of protein localization in cell nucleus|down regulation of protein localization in nucleus|down regulation of protein localization to nucleus|down-regulation of protein localisation to nucleus|down-regulation of protein localization in cell nucleus|down-regulation of protein localization in nucleus|down-regulation of protein localization to nucleus|downregulation of protein localisation to nucleus|downregulation of protein localization in cell nucleus|downregulation of protein localization in nucleus|downregulation of protein localization to nucleus|inhibition of protein localisation to nucleus|inhibition of protein localization in cell nucleus|inhibition of protein localization in nucleus|inhibition of protein localization to nucleus|negative regulation of protein localisation to nucleus|negative regulation of protein localization in cell nucleus|negative regulation of protein localization in nucleus http://purl.obolibrary.org/obo/GO_1900181 GO:1900180 biolink:BiologicalProcess regulation of protein localization to nucleus Any process that modulates the frequency, rate or extent of protein localization to nucleus. go.json regulation of protein localisation to nucleus|regulation of protein localization in cell nucleus|regulation of protein localization in nucleus http://purl.obolibrary.org/obo/GO_1900180 GO:0071297 biolink:BiologicalProcess cellular response to cobalamin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. go.json cellular response to vitamin B12 http://purl.obolibrary.org/obo/GO_0071297 GO:0071296 biolink:BiologicalProcess cellular response to biotin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus. go.json cellular response to Bios IIB|cellular response to coenzyme R|cellular response to vitamin B7|cellular response to vitamin H http://purl.obolibrary.org/obo/GO_0071296 GO:0071295 biolink:BiologicalProcess cellular response to vitamin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071295 GO:0071294 biolink:BiologicalProcess cellular response to zinc ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. go.json cellular response to zinc http://purl.obolibrary.org/obo/GO_0071294 GO:0071293 biolink:BiologicalProcess cellular response to tellurium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus. go.json cellular response to tellurium http://purl.obolibrary.org/obo/GO_0071293 GO:0071292 biolink:BiologicalProcess cellular response to silver ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0071292 GO:0071291 biolink:BiologicalProcess cellular response to selenium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. go.json http://purl.obolibrary.org/obo/GO_0071291 GO:0071290 biolink:BiologicalProcess cellular response to platinum ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus. go.json cellular response to platinum http://purl.obolibrary.org/obo/GO_0071290 GO:1900187 biolink:BiologicalProcess regulation of cell adhesion involved in single-species biofilm formation Any process that modulates the frequency, rate or extent of cell adhesion involved in single-species biofilm formation. go.json regulation of cell adhesion during single-species biofilm formation http://purl.obolibrary.org/obo/GO_1900187 GO:1900186 biolink:BiologicalProcess negative regulation of clathrin-dependent endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis. go.json down regulation of clathrin coated pit-dependent endocytosis|down regulation of clathrin-dependent endocytosis|down regulation of clathrin-mediated endocytosis|down-regulation of clathrin coated pit-dependent endocytosis|down-regulation of clathrin-dependent endocytosis|down-regulation of clathrin-mediated endocytosis|downregulation of clathrin coated pit-dependent endocytosis|downregulation of clathrin-dependent endocytosis|downregulation of clathrin-mediated endocytosis|inhibition of clathrin coated pit-dependent endocytosis|inhibition of clathrin-dependent endocytosis|inhibition of clathrin-mediated endocytosis|negative regulation of clathrin coated pit-dependent endocytosis|negative regulation of clathrin-mediated endocytosis http://purl.obolibrary.org/obo/GO_1900186 GO:1900189 biolink:BiologicalProcess positive regulation of cell adhesion involved in single-species biofilm formation Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation. go.json activation of cell adhesion during single-species biofilm formation|activation of cell adhesion involved in single-species biofilm formation|positive regulation of cell adhesion during single-species biofilm formation|up regulation of cell adhesion during single-species biofilm formation|up regulation of cell adhesion involved in single-species biofilm formation|up-regulation of cell adhesion during single-species biofilm formation|up-regulation of cell adhesion involved in single-species biofilm formation|upregulation of cell adhesion during single-species biofilm formation|upregulation of cell adhesion involved in single-species biofilm formation http://purl.obolibrary.org/obo/GO_1900189 GO:1900188 biolink:BiologicalProcess negative regulation of cell adhesion involved in single-species biofilm formation Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in single-species biofilm formation. go.json down regulation of cell adhesion during single-species biofilm formation|down regulation of cell adhesion involved in single-species biofilm formation|down-regulation of cell adhesion during single-species biofilm formation|down-regulation of cell adhesion involved in single-species biofilm formation|downregulation of cell adhesion during single-species biofilm formation|downregulation of cell adhesion involved in single-species biofilm formation|inhibition of cell adhesion during single-species biofilm formation|inhibition of cell adhesion involved in single-species biofilm formation|negative regulation of cell adhesion during single-species biofilm formation http://purl.obolibrary.org/obo/GO_1900188 GO:1900194 biolink:BiologicalProcess negative regulation of oocyte maturation Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. go.json down regulation of oocyte maturation|down-regulation of oocyte maturation|downregulation of oocyte maturation|inhibition of oocyte maturation http://purl.obolibrary.org/obo/GO_1900194 GO:1900193 biolink:BiologicalProcess regulation of oocyte maturation Any process that modulates the frequency, rate or extent of oocyte maturation. go.json http://purl.obolibrary.org/obo/GO_1900193 GO:1900196 biolink:BiologicalProcess regulation of penicillin biosynthetic process Any process that modulates the frequency, rate or extent of penicillin biosynthetic process. go.json regulation of penicillin anabolism|regulation of penicillin biosynthesis|regulation of penicillin formation|regulation of penicillin synthesis http://purl.obolibrary.org/obo/GO_1900196 GO:1900195 biolink:BiologicalProcess positive regulation of oocyte maturation Any process that activates or increases the frequency, rate or extent of oocyte maturation. go.json activation of oocyte maturation|up regulation of oocyte maturation|up-regulation of oocyte maturation|upregulation of oocyte maturation http://purl.obolibrary.org/obo/GO_1900195 GO:1900190 biolink:BiologicalProcess regulation of single-species biofilm formation Any process that modulates the frequency, rate or extent of single-species biofilm formation. go.json http://purl.obolibrary.org/obo/GO_1900190 GO:1900192 biolink:BiologicalProcess positive regulation of single-species biofilm formation Any process that activates or increases the frequency, rate or extent of single-species biofilm formation. go.json activation of single-species biofilm formation|up regulation of single-species biofilm formation|up-regulation of single-species biofilm formation|upregulation of single-species biofilm formation http://purl.obolibrary.org/obo/GO_1900192 GO:1900191 biolink:BiologicalProcess negative regulation of single-species biofilm formation Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation. go.json down regulation of single-species biofilm formation|down-regulation of single-species biofilm formation|downregulation of single-species biofilm formation|inhibition of single-species biofilm formation http://purl.obolibrary.org/obo/GO_1900191 GO:0071299 biolink:BiologicalProcess cellular response to vitamin A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. go.json cellular response to retinol http://purl.obolibrary.org/obo/GO_0071299 GO:0071298 biolink:BiologicalProcess cellular response to L-ascorbic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. go.json cellular response to L-ascorbate|cellular response to ascorbic acid|cellular response to vitamin C http://purl.obolibrary.org/obo/GO_0071298 GO:0046206 biolink:BiologicalProcess trypanothione metabolic process The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress. go.json trypanothione metabolism http://purl.obolibrary.org/obo/GO_0046206 GO:0046205 biolink:BiologicalProcess nor-spermidine catabolic process The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. go.json nor-spermidine breakdown|nor-spermidine catabolism|nor-spermidine degradation http://purl.obolibrary.org/obo/GO_0046205 GO:0046204 biolink:BiologicalProcess nor-spermidine metabolic process The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. go.json nor-spermidine metabolism http://purl.obolibrary.org/obo/GO_0046204 GO:0046203 biolink:BiologicalProcess spermidine catabolic process The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. go.json spermidine breakdown|spermidine catabolism|spermidine degradation http://purl.obolibrary.org/obo/GO_0046203 GO:0046202 biolink:BiologicalProcess cyanide biosynthetic process The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. go.json cyanide anabolism|cyanide biosynthesis|cyanide formation|cyanide synthesis http://purl.obolibrary.org/obo/GO_0046202 GO:0046201 biolink:BiologicalProcess cyanate biosynthetic process The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid. go.json cyanate anabolism|cyanate biosynthesis|cyanate formation|cyanate synthesis http://purl.obolibrary.org/obo/GO_0046201 GO:0046200 biolink:BiologicalProcess obsolete m-cresol biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol. go.json m-cresol anabolism|m-cresol biosynthesis|m-cresol biosynthetic process|m-cresol formation|m-cresol synthesis True http://purl.obolibrary.org/obo/GO_0046200 GO:0061841 biolink:CellularComponent high-affinity iron exporter complex A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment. go.json FET5-FTH1 high affinity iron exporter complex|FET5-FTH1 high-affinity iron exporter complex|high affinity iron exporter complex http://purl.obolibrary.org/obo/GO_0061841 GO:0061840 biolink:MolecularActivity high-affinity ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json high affinity ferrous uptake transmembrane transporter activity|high-affinity ferrous iron uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0061840 GO:0061843 biolink:BiologicalProcess Sertoli cell barrier remodeling The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle. go.json SCB remodeling|Sertoli cell barrier remodelling|Sertoli cell barrier restructuring|blood testis barrier restructuring|restructuring of BTB|restructuring of SCB|restructuring of blood-testis barrier http://purl.obolibrary.org/obo/GO_0061843 GO:0061842 biolink:BiologicalProcess microtubule organizing center localization Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell. go.json MTOC localization|MTOC polarity|microtubule organizing center polarity http://purl.obolibrary.org/obo/GO_0061842 GO:0046209 biolink:BiologicalProcess nitric oxide metabolic process The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. go.json nitric oxide metabolism http://purl.obolibrary.org/obo/GO_0046209 GO:0061845 biolink:CellularComponent neuron projection branch point The location where a secondary projection arises from a neuron projection. go.json http://purl.obolibrary.org/obo/GO_0061845 GO:0046208 biolink:BiologicalProcess spermine catabolic process The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. go.json spermine breakdown|spermine catabolism|spermine degradation http://purl.obolibrary.org/obo/GO_0046208 GO:0046207 biolink:BiologicalProcess trypanothione catabolic process The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress. go.json trypanothione breakdown|trypanothione catabolism|trypanothione degradation http://purl.obolibrary.org/obo/GO_0046207 GO:0061844 biolink:BiologicalProcess antimicrobial humoral immune response mediated by antimicrobial peptide An immune response against microbes mediated by anti-microbial peptides in body fluid. go.json antimicrobial peptide-mediated antimicrobial humoral response|peptide-mediated antimicrobial humoral response http://purl.obolibrary.org/obo/GO_0061844 GO:0061847 biolink:BiologicalProcess response to cholecystokinin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus. go.json http://purl.obolibrary.org/obo/GO_0061847 GO:0061846 biolink:CellularComponent dendritic spine cytoplasm The region of the neuronal cytoplasm located in dendritic spines. go.json http://purl.obolibrary.org/obo/GO_0061846 GO:0061849 biolink:MolecularActivity telomeric G-quadruplex DNA binding Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres. go.json http://purl.obolibrary.org/obo/GO_0061849 GO:0061848 biolink:BiologicalProcess cellular response to cholecystokinin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus. go.json http://purl.obolibrary.org/obo/GO_0061848 GO:0046217 biolink:BiologicalProcess indole phytoalexin metabolic process The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response. go.json indole phytoalexin metabolism http://purl.obolibrary.org/obo/GO_0046217 GO:0046216 biolink:BiologicalProcess indole phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response. go.json indole phytoalexin breakdown|indole phytoalexin catabolism|indole phytoalexin degradation http://purl.obolibrary.org/obo/GO_0046216 GO:0046215 biolink:BiologicalProcess siderophore catabolic process The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. go.json siderochrome catabolism|siderophore breakdown|siderophore catabolism|siderophore degradation http://purl.obolibrary.org/obo/GO_0046215 GO:0046214 biolink:BiologicalProcess enterobactin catabolic process The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. go.json enterobactin breakdown|enterobactin catabolism|enterobactin degradation http://purl.obolibrary.org/obo/GO_0046214 GO:0046213 biolink:BiologicalProcess methyl ethyl ketone catabolic process The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. go.json methyl ethyl ketone breakdown|methyl ethyl ketone catabolism|methyl ethyl ketone degradation http://purl.obolibrary.org/obo/GO_0046213 GO:0046212 biolink:BiologicalProcess obsolete methyl ethyl ketone biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints. go.json methyl ethyl ketone anabolism|methyl ethyl ketone biosynthesis|methyl ethyl ketone biosynthetic process|methyl ethyl ketone formation|methyl ethyl ketone synthesis True http://purl.obolibrary.org/obo/GO_0046212 GO:0046211 biolink:BiologicalProcess (+)-camphor biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone. go.json (+)-camphor anabolism|(+)-camphor biosynthesis|(+)-camphor formation|(+)-camphor synthesis http://purl.obolibrary.org/obo/GO_0046211 GO:0046210 biolink:BiologicalProcess nitric oxide catabolic process The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. go.json nitric oxide breakdown|nitric oxide catabolism|nitric oxide degradation http://purl.obolibrary.org/obo/GO_0046210 GO:0061830 biolink:CellularComponent concave side of sperm head The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species. go.json http://purl.obolibrary.org/obo/GO_0061830 GO:0061832 biolink:CellularComponent basal ectoplasmic specialization Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell. go.json basal ES http://purl.obolibrary.org/obo/GO_0061832 GO:0061831 biolink:CellularComponent apical ectoplasmic specialization Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell. go.json apical ES http://purl.obolibrary.org/obo/GO_0061831 GO:0061834 biolink:CellularComponent actin filament branch point The part of an actin filament where the structure forks. go.json microfilament branch point http://purl.obolibrary.org/obo/GO_0061834 GO:0046219 biolink:BiologicalProcess indolalkylamine biosynthetic process The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. go.json indolalkylamine anabolism|indolalkylamine biosynthesis|indolalkylamine formation|indolalkylamine synthesis http://purl.obolibrary.org/obo/GO_0046219 GO:0061833 biolink:BiologicalProcess protein localization to tricellular tight junction A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction. go.json http://purl.obolibrary.org/obo/GO_0061833 GO:0046218 biolink:BiologicalProcess obsolete indolalkylamine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. go.json indolalkylamine breakdown|indolalkylamine catabolism|indolalkylamine degradation True http://purl.obolibrary.org/obo/GO_0046218 GO:0061836 biolink:CellularComponent intranuclear rod A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions. go.json intranuclear actin rod http://purl.obolibrary.org/obo/GO_0061836 GO:0061835 biolink:CellularComponent ventral surface of cell The surface of a migrating cell that is in contact with the substratum or cell layer. go.json http://purl.obolibrary.org/obo/GO_0061835 GO:0061838 biolink:CellularComponent CENP-T-W-S-X complex A histone-variant containing protein complex which forms a centromere specific nucleosome-like structure, involved in centromeric chromatin organization. go.json http://purl.obolibrary.org/obo/GO_0061838 GO:0061837 biolink:BiologicalProcess neuropeptide processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide. go.json http://purl.obolibrary.org/obo/GO_0061837 GO:0061839 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061839 GO:0046220 biolink:BiologicalProcess pyridine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. go.json pyridine anabolism|pyridine biosynthesis|pyridine formation|pyridine synthesis http://purl.obolibrary.org/obo/GO_0046220 GO:0046228 biolink:BiologicalProcess 2,4,5-trichlorophenoxyacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide. go.json 2,4,5-trichlorophenoxyacetic acid breakdown|2,4,5-trichlorophenoxyacetic acid catabolism|2,4,5-trichlorophenoxyacetic acid degradation http://purl.obolibrary.org/obo/GO_0046228 GO:0046227 biolink:BiologicalProcess obsolete 2,4,5-trichlorophenoxyacetic acid biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide. go.json 2,4,5-trichlorophenoxyacetic acid anabolism|2,4,5-trichlorophenoxyacetic acid biosynthesis|2,4,5-trichlorophenoxyacetic acid biosynthetic process|2,4,5-trichlorophenoxyacetic acid formation|2,4,5-trichlorophenoxyacetic acid synthesis True http://purl.obolibrary.org/obo/GO_0046227 GO:0046226 biolink:BiologicalProcess coumarin catabolic process The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. go.json coumarin breakdown|coumarin catabolism|coumarin degradation http://purl.obolibrary.org/obo/GO_0046226 GO:0046225 biolink:BiologicalProcess bacteriocin catabolic process The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. go.json bacteriocin breakdown|bacteriocin catabolism|bacteriocin degradation http://purl.obolibrary.org/obo/GO_0046225 GO:0046224 biolink:BiologicalProcess bacteriocin metabolic process The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. go.json bacteriocin metabolism http://purl.obolibrary.org/obo/GO_0046224 GO:0046223 biolink:BiologicalProcess aflatoxin catabolic process The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. go.json aflatoxin breakdown|aflatoxin catabolism|aflatoxin degradation http://purl.obolibrary.org/obo/GO_0046223 GO:0046222 biolink:BiologicalProcess aflatoxin metabolic process The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. go.json aflatoxin B metabolic process|aflatoxin B1 metabolic process|aflatoxin B1 metabolism|aflatoxin B2 metabolic process|aflatoxin B2 metabolism|aflatoxin metabolism http://purl.obolibrary.org/obo/GO_0046222 GO:0046221 biolink:BiologicalProcess pyridine catabolic process The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. go.json pyridine breakdown|pyridine catabolism|pyridine degradation http://purl.obolibrary.org/obo/GO_0046221 GO:0061860 biolink:MolecularActivity DNA clamp unloader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis. go.json DNA clamp unloading activity http://purl.obolibrary.org/obo/GO_0061860 GO:0061863 biolink:MolecularActivity microtubule plus end polymerase Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers. go.json http://purl.obolibrary.org/obo/GO_0061863 GO:0061862 biolink:BiologicalProcess cellular response to differentiation-inducing factor 2 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus. go.json cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one|cellular response to DIF-2|cellular response to DIF2 http://purl.obolibrary.org/obo/GO_0061862 GO:0061865 biolink:BiologicalProcess polarized secretion of basement membrane proteins in epithelium The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium. go.json http://purl.obolibrary.org/obo/GO_0061865 GO:0061864 biolink:BiologicalProcess basement membrane constituent secretion The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell. go.json http://purl.obolibrary.org/obo/GO_0061864 GO:0061867 biolink:BiologicalProcess establishment of mitotic spindle asymmetry The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure. go.json http://purl.obolibrary.org/obo/GO_0061867 GO:0061866 biolink:BiologicalProcess obsolete negative regulation of histone H3-S10 phosphorylation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to histone H3 on a serine residue at position 10. go.json True http://purl.obolibrary.org/obo/GO_0061866 GO:0046229 biolink:BiologicalProcess obsolete 2-aminobenzenesulfonate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. go.json 2-aminobenzenesulfonate anabolism|2-aminobenzenesulfonate biosynthesis|2-aminobenzenesulfonate biosynthetic process|2-aminobenzenesulfonate formation|2-aminobenzenesulfonate synthesis|2-aminobenzenesulphonate biosynthesis|2-aminobenzenesulphonate biosynthetic process True http://purl.obolibrary.org/obo/GO_0046229 GO:0061869 biolink:BiologicalProcess regulation of hepatic stellate cell migration Any process that modulates the frequency, rate or extent of hepatic stellate cell migration. go.json http://purl.obolibrary.org/obo/GO_0061869 GO:0061868 biolink:BiologicalProcess hepatic stellate cell migration The orderly movement of a hepatic stellate cell from one site to another. go.json http://purl.obolibrary.org/obo/GO_0061868 GO:0046231 biolink:BiologicalProcess obsolete carbazole biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. go.json carbazole anabolism|carbazole biosynthesis|carbazole biosynthetic process|carbazole formation|carbazole synthesis True http://purl.obolibrary.org/obo/GO_0046231 GO:0046230 biolink:BiologicalProcess 2-aminobenzenesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. go.json 2-aminobenzenesulfonate breakdown|2-aminobenzenesulfonate catabolism|2-aminobenzenesulfonate degradation|2-aminobenzenesulphonate catabolic process|2-aminobenzenesulphonate catabolism http://purl.obolibrary.org/obo/GO_0046230 GO:0046239 biolink:BiologicalProcess phthalate catabolic process The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid. go.json phthalate breakdown|phthalate catabolism|phthalate degradation http://purl.obolibrary.org/obo/GO_0046239 GO:0046238 biolink:BiologicalProcess obsolete phthalate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid. go.json phthalate anabolism|phthalate biosynthesis|phthalate biosynthetic process|phthalate formation|phthalate synthesis True http://purl.obolibrary.org/obo/GO_0046238 GO:0046237 biolink:BiologicalProcess obsolete phenanthrene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon. go.json phenanthrene anabolism|phenanthrene biosynthesis|phenanthrene biosynthetic process|phenanthrene formation|phenanthrene synthesis True http://purl.obolibrary.org/obo/GO_0046237 GO:0046236 biolink:BiologicalProcess mandelate biosynthetic process The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. go.json mandelate anabolism|mandelate biosynthesis|mandelate formation|mandelate synthesis http://purl.obolibrary.org/obo/GO_0046236 GO:0046235 biolink:BiologicalProcess obsolete gallate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). go.json gallate anabolism|gallate biosynthesis|gallate formation|gallate synthesis|gallic acid biosynthesis|gallic acid biosynthetic process True http://purl.obolibrary.org/obo/GO_0046235 GO:0046234 biolink:BiologicalProcess obsolete fluorene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents. go.json fluorene anabolism|fluorene biosynthesis|fluorene biosynthetic process|fluorene formation|fluorene synthesis True http://purl.obolibrary.org/obo/GO_0046234 GO:0046233 biolink:BiologicalProcess obsolete 3-hydroxyphenylacetate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. go.json 3-hydroxyphenylacetate anabolism|3-hydroxyphenylacetate biosynthesis|3-hydroxyphenylacetate biosynthetic process|3-hydroxyphenylacetate formation|3-hydroxyphenylacetate synthesis True http://purl.obolibrary.org/obo/GO_0046233 GO:0046232 biolink:BiologicalProcess carbazole catabolic process The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. go.json carbazole breakdown|carbazole catabolism|carbazole degradation http://purl.obolibrary.org/obo/GO_0046232 GO:0061850 biolink:CellularComponent growth cone leading edge That part of the growth cone which represents the distal part of the structure. go.json http://purl.obolibrary.org/obo/GO_0061850 GO:0061852 biolink:CellularComponent retrograde transporter complex, Golgi to ER Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles. go.json ERV41-ERV46 retrograde receptor complex|retrograde receptor complex, Golgi to ER|retrograde receptor complex, Golgi to endoplasmic reticulum|retrograde transporter complex, Golgi to endoplasmic reticulum http://purl.obolibrary.org/obo/GO_0061852 GO:0061851 biolink:CellularComponent leading edge of lamellipodium That part of the lamellipodium which represents the distal part of the structure. go.json http://purl.obolibrary.org/obo/GO_0061851 GO:0061854 biolink:BiologicalProcess positive regulation of neuroblast migration Any process that activates or increases the frequency, rate or extent of neuroblast migration. go.json http://purl.obolibrary.org/obo/GO_0061854 GO:0061853 biolink:BiologicalProcess regulation of neuroblast migration Any process that modulates the frequency, rate or extent of neuroblast migration. go.json http://purl.obolibrary.org/obo/GO_0061853 GO:0061856 biolink:BiologicalProcess Golgi calcium ion transmembrane transport A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0061856 GO:0061855 biolink:BiologicalProcess negative regulation of neuroblast migration Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration. go.json http://purl.obolibrary.org/obo/GO_0061855 GO:0061857 biolink:BiologicalProcess endoplasmic reticulum stress-induced pre-emptive quality control The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome. go.json ER pQC|ER stress-indiced pre-emptive quality control http://purl.obolibrary.org/obo/GO_0061857 GO:0046242 biolink:BiologicalProcess obsolete o-xylene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. go.json o-xylene anabolism|o-xylene biosynthesis|o-xylene biosynthetic process|o-xylene formation|o-xylene synthesis|ortho-xylene biosynthesis|ortho-xylene biosynthetic process True http://purl.obolibrary.org/obo/GO_0046242 GO:0046241 biolink:BiologicalProcess obsolete m-xylene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon. go.json m-xylene anabolism|m-xylene biosynthesis|m-xylene biosynthetic process|m-xylene formation|m-xylene synthesis|meta-xylene biosynthesis|meta-xylene biosynthetic process True http://purl.obolibrary.org/obo/GO_0046241 GO:0046240 biolink:BiologicalProcess obsolete xylene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. go.json xylene anabolism|xylene biosynthesis|xylene biosynthetic process|xylene formation|xylene synthesis True http://purl.obolibrary.org/obo/GO_0046240 GO:0046249 biolink:BiologicalProcess alpha-pinene catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. go.json alpha-pinene breakdown|alpha-pinene catabolism|alpha-pinene degradation http://purl.obolibrary.org/obo/GO_0046249 GO:0046248 biolink:BiologicalProcess alpha-pinene biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. go.json alpha-pinene anabolism|alpha-pinene biosynthesis|alpha-pinene formation|alpha-pinene synthesis http://purl.obolibrary.org/obo/GO_0046248 GO:0046247 biolink:BiologicalProcess terpene catabolic process The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units. go.json terpene breakdown|terpene catabolism|terpene degradation http://purl.obolibrary.org/obo/GO_0046247 GO:0046246 biolink:BiologicalProcess terpene biosynthetic process The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units. go.json terpene anabolism|terpene biosynthesis|terpene formation|terpene synthesis http://purl.obolibrary.org/obo/GO_0046246 GO:0046245 biolink:BiologicalProcess obsolete styrene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene. go.json styrene anabolism|styrene biosynthesis|styrene biosynthetic process|styrene formation|styrene synthesis True http://purl.obolibrary.org/obo/GO_0046245 GO:0046244 biolink:BiologicalProcess salicylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. go.json salicylic acid breakdown|salicylic acid catabolism|salicylic acid degradation http://purl.obolibrary.org/obo/GO_0046244 GO:0061881 biolink:BiologicalProcess positive regulation of anterograde axonal transport of mitochondrion Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. go.json positive regulation of anterograde axon transport of mitochondria http://purl.obolibrary.org/obo/GO_0061881 GO:0046243 biolink:BiologicalProcess obsolete p-xylene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon. go.json p-xylene anabolism|p-xylene biosynthesis|p-xylene biosynthetic process|p-xylene formation|p-xylene synthesis|para-xylene biosynthesis|para-xylene biosynthetic process True http://purl.obolibrary.org/obo/GO_0046243 GO:0061880 biolink:BiologicalProcess regulation of anterograde axonal transport of mitochondrion Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. go.json regulation of anterograde axon transport of mitochondria http://purl.obolibrary.org/obo/GO_0061880 GO:0061883 biolink:BiologicalProcess clathrin-dependent endocytosis involved in vitellogenesis A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition. go.json clathrin-dependent endocytosis involved in yolk formation http://purl.obolibrary.org/obo/GO_0061883 GO:0061882 biolink:BiologicalProcess negative regulation of anterograde axonal transport of mitochondrion Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. go.json negative regulation of anterograde axon transport of mitochondria http://purl.obolibrary.org/obo/GO_0061882 GO:0061885 biolink:BiologicalProcess positive regulation of mini excitatory postsynaptic potential Any process that increases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. go.json http://purl.obolibrary.org/obo/GO_0061885 GO:0061884 biolink:BiologicalProcess regulation of mini excitatory postsynaptic potential Any process that modulates the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. go.json http://purl.obolibrary.org/obo/GO_0061884 GO:0061887 biolink:BiologicalProcess obsolete reproduction of symbiont in host OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms, occurring within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json True http://purl.obolibrary.org/obo/GO_0061887 GO:0061886 biolink:BiologicalProcess negative regulation of mini excitatory postsynaptic potential Any process that decreases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. go.json http://purl.obolibrary.org/obo/GO_0061886 GO:0071209 biolink:MolecularActivity U7 snRNA binding Binding to a U7 small nuclear RNA (U7 snRNA). go.json http://purl.obolibrary.org/obo/GO_0071209 GO:0071208 biolink:MolecularActivity histone pre-mRNA DCP binding Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing. go.json http://purl.obolibrary.org/obo/GO_0071208 GO:0061889 biolink:BiologicalProcess negative regulation of astrocyte activation Any process that decreases the frequency, rate or extent of astrocyte activation. go.json http://purl.obolibrary.org/obo/GO_0061889 GO:0061888 biolink:BiologicalProcess regulation of astrocyte activation Any process that modulates the frequency, rate or extent of astrocyte activation. go.json http://purl.obolibrary.org/obo/GO_0061888 GO:0071207 biolink:MolecularActivity histone pre-mRNA stem-loop binding Binding to a conserved stem-loop structure found in histone pre-mRNAs. go.json http://purl.obolibrary.org/obo/GO_0071207 GO:0071206 biolink:BiologicalProcess establishment of protein localization to juxtaparanode region of axon The directed movement of a protein to the juxtaparanode region of an axon. go.json establishment of protein localisation to juxtaparanode region of axon http://purl.obolibrary.org/obo/GO_0071206 GO:0071205 biolink:BiologicalProcess protein localization to juxtaparanode region of axon Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon. go.json protein localisation to juxtaparanode region of axon http://purl.obolibrary.org/obo/GO_0071205 GO:0071204 biolink:CellularComponent histone pre-mRNA 3'end processing complex A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1. go.json histone 3'end pre-mRNA complex http://purl.obolibrary.org/obo/GO_0071204 GO:0071203 biolink:CellularComponent WASH complex A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. go.json http://purl.obolibrary.org/obo/GO_0071203 GO:0071202 biolink:CellularComponent Kv4.3-DPP10 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3. CORUM:598 go.json Kv4.3-DPPY channel complex http://purl.obolibrary.org/obo/GO_0071202 GO:0071201 biolink:CellularComponent Kv4.3-DPP6 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3. CORUM:599 go.json Kv4.3-DPPX channel complex http://purl.obolibrary.org/obo/GO_0071201 GO:0071200 biolink:CellularComponent Kv4.2-DPP6 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2. CORUM:603 go.json Kv4.2-DPPX channel complex http://purl.obolibrary.org/obo/GO_0071200 GO:0046253 biolink:BiologicalProcess anaerobic toluene biosynthetic process The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. go.json anaerobic toluene anabolism|anaerobic toluene biosynthesis|anaerobic toluene formation|anaerobic toluene synthesis http://purl.obolibrary.org/obo/GO_0046253 GO:0046252 biolink:BiologicalProcess toluene biosynthetic process The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. go.json toluene anabolism|toluene biosynthesis|toluene formation|toluene synthesis http://purl.obolibrary.org/obo/GO_0046252 GO:0046251 biolink:BiologicalProcess limonene catabolic process The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. go.json limonene breakdown|limonene catabolism|limonene degradation http://purl.obolibrary.org/obo/GO_0046251 GO:0046250 biolink:BiologicalProcess limonene biosynthetic process The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. go.json limonene anabolism|limonene biosynthesis|limonene formation|limonene synthesis http://purl.obolibrary.org/obo/GO_0046250 GO:0046259 biolink:BiologicalProcess obsolete trinitrotoluene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. go.json trinitrotoluene anabolism|trinitrotoluene biosynthesis|trinitrotoluene biosynthetic process|trinitrotoluene formation|trinitrotoluene synthesis True http://purl.obolibrary.org/obo/GO_0046259 GO:0046258 biolink:BiologicalProcess anaerobic 2,4,6-trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen. go.json anaerobic 2,4,6-trinitrotoluene breakdown|anaerobic 2,4,6-trinitrotoluene catabolism|anaerobic 2,4,6-trinitrotoluene degradation http://purl.obolibrary.org/obo/GO_0046258 GO:0046257 biolink:BiologicalProcess obsolete anaerobic 2,4,6-trinitrotoluene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen. go.json anaerobic 2,4,6-trinitrotoluene anabolism|anaerobic 2,4,6-trinitrotoluene biosynthesis|anaerobic 2,4,6-trinitrotoluene biosynthetic process|anaerobic 2,4,6-trinitrotoluene formation|anaerobic 2,4,6-trinitrotoluene synthesis True http://purl.obolibrary.org/obo/GO_0046257 GO:0046256 biolink:BiologicalProcess 2,4,6-trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. go.json 2,4,6-trinitrotoluene breakdown|2,4,6-trinitrotoluene catabolism|2,4,6-trinitrotoluene degradation http://purl.obolibrary.org/obo/GO_0046256 GO:0046255 biolink:BiologicalProcess obsolete 2,4,6-trinitrotoluene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene. go.json 2,4,6-trinitrotoluene anabolism|2,4,6-trinitrotoluene biosynthesis|2,4,6-trinitrotoluene biosynthetic process|2,4,6-trinitrotoluene formation|2,4,6-trinitrotoluene synthesis True http://purl.obolibrary.org/obo/GO_0046255 GO:0061870 biolink:BiologicalProcess positive regulation of hepatic stellate cell migration Any process that increases the frequency, rate or extent of hepatic stellate cell migration. go.json http://purl.obolibrary.org/obo/GO_0061870 GO:0046254 biolink:BiologicalProcess anaerobic toluene catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. MetaCyc:PWY-81 go.json anaerobic toluene breakdown|anaerobic toluene catabolism|anaerobic toluene degradation http://purl.obolibrary.org/obo/GO_0046254 GO:0061872 biolink:BiologicalProcess hepatic stellate cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a hepatic stellate cell. go.json http://purl.obolibrary.org/obo/GO_0061872 GO:0061871 biolink:BiologicalProcess negative regulation of hepatic stellate cell migration Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration. go.json http://purl.obolibrary.org/obo/GO_0061871 GO:0061874 biolink:BiologicalProcess positive regulation of hepatic stellate cell contraction Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction. go.json http://purl.obolibrary.org/obo/GO_0061874 GO:0061873 biolink:BiologicalProcess regulation of hepatic stellate cell contraction Any process that modulates the frequency, rate or extent of hepatic stellate cell contraction. go.json http://purl.obolibrary.org/obo/GO_0061873 GO:0061875 biolink:BiologicalProcess negative regulation of hepatic stellate cell contraction Any process that modulates stops, prevents, or reduces the frequency, rate or extent of hepatic stellate cell contraction. go.json http://purl.obolibrary.org/obo/GO_0061875 GO:0046264 biolink:BiologicalProcess obsolete thiocyanate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid. go.json thiocyanate anabolism|thiocyanate biosynthesis|thiocyanate biosynthetic process|thiocyanate formation|thiocyanate synthesis True http://purl.obolibrary.org/obo/GO_0046264 GO:0071220 biolink:BiologicalProcess cellular response to bacterial lipoprotein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. go.json http://purl.obolibrary.org/obo/GO_0071220 GO:0046263 biolink:BiologicalProcess nitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. go.json nitrotoluene breakdown|nitrotoluene catabolism|nitrotoluene degradation http://purl.obolibrary.org/obo/GO_0046263 GO:0046262 biolink:BiologicalProcess obsolete nitrotoluene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. go.json nitrotoluene anabolism|nitrotoluene biosynthesis|nitrotoluene biosynthetic process|nitrotoluene formation|nitrotoluene synthesis True http://purl.obolibrary.org/obo/GO_0046262 GO:0046261 biolink:BiologicalProcess obsolete 4-nitrotoluene biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene. go.json 4-nitrotoluene anabolism|4-nitrotoluene biosynthesis|4-nitrotoluene biosynthetic process|4-nitrotoluene formation|4-nitrotoluene synthesis|4NT biosynthesis|4NT biosynthetic process True http://purl.obolibrary.org/obo/GO_0046261 GO:0046260 biolink:BiologicalProcess trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene. go.json trinitrotoluene breakdown|trinitrotoluene catabolism|trinitrotoluene degradation http://purl.obolibrary.org/obo/GO_0046260 GO:0046269 biolink:BiologicalProcess toluene-4-sulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule. go.json 4-toluenesulfonate catabolic process|4-toluenesulfonate catabolism|toluene-4-sulfonate breakdown|toluene-4-sulfonate catabolism|toluene-4-sulfonate degradation|toluene-4-sulphonate catabolic process|toluene-4-sulphonate catabolism http://purl.obolibrary.org/obo/GO_0046269 GO:0046268 biolink:BiologicalProcess obsolete toluene-4-sulfonate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule. go.json 4-toluenesulfonate biosynthesis|4-toluenesulfonate biosynthetic process|toluene-4-sulfonate anabolism|toluene-4-sulfonate biosynthesis|toluene-4-sulfonate biosynthetic process|toluene-4-sulfonate formation|toluene-4-sulfonate synthesis|toluene-4-sulphonate biosynthesis|toluene-4-sulphonate biosynthetic process True http://purl.obolibrary.org/obo/GO_0046268 GO:0046267 biolink:BiologicalProcess obsolete triethanolamine catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. go.json triethanolamine breakdown|triethanolamine catabolism|triethanolamine degradation True http://purl.obolibrary.org/obo/GO_0046267 GO:0046266 biolink:BiologicalProcess obsolete triethanolamine biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. go.json triethanolamine anabolism|triethanolamine biosynthesis|triethanolamine biosynthetic process|triethanolamine formation|triethanolamine synthesis True http://purl.obolibrary.org/obo/GO_0046266 GO:0046265 biolink:BiologicalProcess thiocyanate catabolic process The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid. go.json thiocyanate breakdown|thiocyanate catabolism|thiocyanate degradation http://purl.obolibrary.org/obo/GO_0046265 GO:0071229 biolink:BiologicalProcess cellular response to acid chemical Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. go.json cellular response to acid|cellular response to acid anion|cellular response to oxoanion http://purl.obolibrary.org/obo/GO_0071229 gocheck_do_not_manually_annotate GO:0071228 biolink:BiologicalProcess cellular response to tumor cell Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. go.json http://purl.obolibrary.org/obo/GO_0071228 GO:0071227 biolink:BiologicalProcess cellular response to molecule of oomycetes origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. go.json cellular response to oomycetes associated molecule http://purl.obolibrary.org/obo/GO_0071227 GO:0071226 biolink:BiologicalProcess cellular response to molecule of fungal origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. go.json cellular response to fungus associated molecule http://purl.obolibrary.org/obo/GO_0071226 GO:0071225 biolink:BiologicalProcess cellular response to muramyl dipeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. go.json http://purl.obolibrary.org/obo/GO_0071225 GO:0071224 biolink:BiologicalProcess cellular response to peptidoglycan Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. go.json http://purl.obolibrary.org/obo/GO_0071224 GO:0071223 biolink:BiologicalProcess cellular response to lipoteichoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. go.json cellular response to LTA http://purl.obolibrary.org/obo/GO_0071223 GO:0071222 biolink:BiologicalProcess cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. go.json cellular response to LPS|cellular response to endotoxin http://purl.obolibrary.org/obo/GO_0071222 GO:0071221 biolink:BiologicalProcess cellular response to bacterial lipopeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus. go.json http://purl.obolibrary.org/obo/GO_0071221 GO:0046275 biolink:BiologicalProcess flavonoid catabolic process The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton. go.json flavonoid breakdown|flavonoid catabolism|flavonoid degradation http://purl.obolibrary.org/obo/GO_0046275 GO:0046274 biolink:BiologicalProcess lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. go.json lignin breakdown|lignin catabolism|lignin degradation http://purl.obolibrary.org/obo/GO_0046274 GO:0046273 biolink:BiologicalProcess lignan catabolic process The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. go.json lignan breakdown|lignan catabolism|lignan degradation http://purl.obolibrary.org/obo/GO_0046273 GO:0046272 biolink:BiologicalProcess stilbene catabolic process The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. go.json stilbene breakdown|stilbene catabolism|stilbene degradation http://purl.obolibrary.org/obo/GO_0046272 GO:1900107 biolink:BiologicalProcess regulation of nodal signaling pathway Any process that modulates the frequency, rate or extent of nodal signaling pathway. go.json regulation of nodal signaling|regulation of nodal signalling pathway http://purl.obolibrary.org/obo/GO_1900107 GO:0046271 biolink:BiologicalProcess phenylpropanoid catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid. go.json phenylpropanoid breakdown|phenylpropanoid catabolism|phenylpropanoid degradation http://purl.obolibrary.org/obo/GO_0046271 GO:1900106 biolink:BiologicalProcess positive regulation of hyaluranon cable assembly Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly. go.json activation of HA cable assembly|activation of hyaluranon cable assembly|positive regulation of HA cable assembly|up regulation of HA cable assembly|up regulation of hyaluranon cable assembly|up-regulation of HA cable assembly|up-regulation of hyaluranon cable assembly|upregulation of HA cable assembly|upregulation of hyaluranon cable assembly http://purl.obolibrary.org/obo/GO_1900106 GO:0046270 biolink:BiologicalProcess obsolete 4-toluenecarboxylate biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. go.json 4-toluenecarboxylate anabolism|4-toluenecarboxylate biosynthesis|4-toluenecarboxylate biosynthetic process|4-toluenecarboxylate formation|4-toluenecarboxylate synthesis True http://purl.obolibrary.org/obo/GO_0046270 GO:1900109 biolink:BiologicalProcess regulation of histone H3-K9 dimethylation Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation. go.json regulation of histone H3 K9 dimethylation|regulation of histone lysine H3 K9 dimethylation http://purl.obolibrary.org/obo/GO_1900109 GO:1900108 biolink:BiologicalProcess negative regulation of nodal signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway. go.json down regulation of nodal signaling|down regulation of nodal signaling pathway|down-regulation of nodal signaling|down-regulation of nodal signaling pathway|downregulation of nodal signaling|downregulation of nodal signaling pathway|inhibition of nodal signaling|inhibition of nodal signaling pathway|negative regulation of nodal signaling|negative regulation of nodal signalling pathway http://purl.obolibrary.org/obo/GO_1900108 GO:1900103 biolink:BiologicalProcess positive regulation of endoplasmic reticulum unfolded protein response Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. go.json activation of ER unfolded protein response|activation of SREBP-mediated signalling pathway|activation of endoplasmic reticulum unfolded protein response|activation of erUPR|positive regulation of ER unfolded protein response|positive regulation of SREBP-mediated signalling pathway|positive regulation of erUPR|up regulation of ER unfolded protein response|up regulation of SREBP-mediated signalling pathway|up regulation of endoplasmic reticulum unfolded protein response|up regulation of erUPR|up-regulation of ER unfolded protein response|up-regulation of SREBP-mediated signalling pathway|up-regulation of endoplasmic reticulum unfolded protein response|up-regulation of erUPR|upregulation of ER unfolded protein response|upregulation of SREBP-mediated signalling pathway|upregulation of endoplasmic reticulum unfolded protein response|upregulation of erUPR http://purl.obolibrary.org/obo/GO_1900103 GO:1900102 biolink:BiologicalProcess negative regulation of endoplasmic reticulum unfolded protein response Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. go.json down regulation of ER unfolded protein response|down regulation of SREBP-mediated signalling pathway|down regulation of endoplasmic reticulum unfolded protein response|down regulation of erUPR|down-regulation of ER unfolded protein response|down-regulation of SREBP-mediated signalling pathway|down-regulation of endoplasmic reticulum unfolded protein response|down-regulation of erUPR|downregulation of ER unfolded protein response|downregulation of SREBP-mediated signalling pathway|downregulation of endoplasmic reticulum unfolded protein response|downregulation of erUPR|inhibition of ER unfolded protein response|inhibition of SREBP-mediated signalling pathway|inhibition of endoplasmic reticulum unfolded protein response|inhibition of erUPR|negative regulation of ER unfolded protein response|negative regulation of SREBP-mediated signalling pathway|negative regulation of erUPR http://purl.obolibrary.org/obo/GO_1900102 GO:1900105 biolink:BiologicalProcess negative regulation of hyaluranon cable assembly Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly. go.json down regulation of HA cable assembly|down regulation of hyaluranon cable assembly|down-regulation of HA cable assembly|down-regulation of hyaluranon cable assembly|downregulation of HA cable assembly|downregulation of hyaluranon cable assembly|inhibition of HA cable assembly|inhibition of hyaluranon cable assembly|negative regulation of HA cable assembly http://purl.obolibrary.org/obo/GO_1900105 GO:1900104 biolink:BiologicalProcess regulation of hyaluranon cable assembly Any process that modulates the frequency, rate or extent of hyaluranon cable assembly. go.json regulation of HA cable assembly http://purl.obolibrary.org/obo/GO_1900104 GO:0061890 biolink:BiologicalProcess positive regulation of astrocyte activation Any process that increases the frequency, rate or extent of astrocyte activation. go.json http://purl.obolibrary.org/obo/GO_0061890 GO:0046279 biolink:BiologicalProcess 3,4-dihydroxybenzoate biosynthetic process The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. go.json protocatechuate anabolism|protocatechuate biosynthesis|protocatechuate biosynthetic process|protocatechuate formation|protocatechuate synthesis http://purl.obolibrary.org/obo/GO_0046279 GO:0046278 biolink:BiologicalProcess 3,4-dihydroxybenzoate metabolic process The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). go.json protocatechuate metabolic process|protocatechuate metabolism http://purl.obolibrary.org/obo/GO_0046278 GO:0046277 biolink:BiologicalProcess methylgallate biosynthetic process The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. go.json methylgallate anabolism|methylgallate biosynthesis|methylgallate formation|methylgallate synthesis http://purl.obolibrary.org/obo/GO_0046277 GO:1900101 biolink:BiologicalProcess regulation of endoplasmic reticulum unfolded protein response Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. go.json regulation of ER unfolded protein response|regulation of SREBP-mediated signalling pathway|regulation of erUPR http://purl.obolibrary.org/obo/GO_1900101 GO:1900100 biolink:BiologicalProcess positive regulation of plasma cell differentiation Any process that activates or increases the frequency, rate or extent of plasma cell differentiation. go.json activation of plasma cell development|activation of plasma cell differentiation|positive regulation of plasma cell development|up regulation of plasma cell development|up regulation of plasma cell differentiation|up-regulation of plasma cell development|up-regulation of plasma cell differentiation|upregulation of plasma cell development|upregulation of plasma cell differentiation http://purl.obolibrary.org/obo/GO_1900100 GO:0046276 biolink:BiologicalProcess methylgallate catabolic process The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. MetaCyc:METHYLGALLATE-DEGRADATION-PWY go.json methylgallate breakdown|methylgallate catabolism|methylgallate degradation http://purl.obolibrary.org/obo/GO_0046276 GO:0061891 biolink:MolecularActivity calcium ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+). go.json http://purl.obolibrary.org/obo/GO_0061891 GO:0061896 biolink:MolecularActivity all-trans retinol 3,4-desaturase activity Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]. RHEA:50292 go.json http://purl.obolibrary.org/obo/GO_0061896 GO:0061898 biolink:MolecularActivity all-trans retinoic acid 3,4-desaturase activity Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]. go.json http://purl.obolibrary.org/obo/GO_0061898 GO:0061897 biolink:MolecularActivity all-trans retinal 3,4-desaturase activity Catalysis of the reaction: all-trans-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]. go.json http://purl.obolibrary.org/obo/GO_0061897 GO:0071219 biolink:BiologicalProcess cellular response to molecule of bacterial origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. go.json cellular response to bacteria associated molecule|cellular response to bacterial associated molecule|cellular response to bacterium associated molecule http://purl.obolibrary.org/obo/GO_0071219 GO:0061899 biolink:MolecularActivity 11-cis-retinal 3,4-desaturase activity Catalysis of the reaction: 11-cis-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]. go.json http://purl.obolibrary.org/obo/GO_0061899 GO:0071218 biolink:BiologicalProcess cellular response to misfolded protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. go.json http://purl.obolibrary.org/obo/GO_0071218 GO:0071217 biolink:BiologicalProcess cellular response to external biotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. go.json http://purl.obolibrary.org/obo/GO_0071217 GO:0071216 biolink:BiologicalProcess cellular response to biotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. go.json cellular response to biotic stress http://purl.obolibrary.org/obo/GO_0071216 gocheck_do_not_manually_annotate GO:0071215 biolink:BiologicalProcess cellular response to abscisic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071215 GO:0071214 biolink:BiologicalProcess cellular response to abiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. go.json cellular response to abiotic stress http://purl.obolibrary.org/obo/GO_0071214 gocheck_do_not_manually_annotate GO:0071213 biolink:BiologicalProcess cellular response to 1-aminocyclopropane-1-carboxylic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071213 GO:0071212 biolink:CellularComponent subsynaptic reticulum An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. go.json SSR http://purl.obolibrary.org/obo/GO_0071212 GO:0071211 biolink:BiologicalProcess protein targeting to vacuole involved in autophagy The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm. go.json protein targeting to autophagosome http://purl.obolibrary.org/obo/GO_0071211 GO:0071210 biolink:BiologicalProcess protein insertion into membrane raft The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. go.json establishment of protein localization to membrane raft http://purl.obolibrary.org/obo/GO_0071210 GO:0046404 biolink:MolecularActivity ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. KEGG_REACTION:R03840|MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN|RHEA:15669 go.json ATP-dependent DNA kinase activity|polydeoxyribonucleotide 5'-hydroxyl-kinase activity http://purl.obolibrary.org/obo/GO_0046404 GO:0046403 biolink:MolecularActivity polynucleotide 3'-phosphatase activity Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. EC:3.1.3.32|MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN|RHEA:14113|Reactome:R-HSA-5649705 go.json 2'(3')-polynucleotidase activity|5'-polynucleotidekinase 3'-phosphatase activity|DNA 3'-phosphatase activity|deoxyribonucleate 3'-phosphatase activity|polynucleotide 3'-phosphohydrolase activity http://purl.obolibrary.org/obo/GO_0046403 GO:0046402 biolink:BiologicalProcess O antigen metabolic process The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. go.json O antigen metabolism http://purl.obolibrary.org/obo/GO_0046402 GO:0046401 biolink:BiologicalProcess lipopolysaccharide core region metabolic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains. go.json LPS core region metabolic process|lipopolysaccharide core region metabolism http://purl.obolibrary.org/obo/GO_0046401 GO:0046400 biolink:BiologicalProcess keto-3-deoxy-D-manno-octulosonic acid metabolic process The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. go.json KDO metabolic process|KDO metabolism|keto-3-deoxy-D-manno-octulosonic acid metabolism|ketodeoxyoctanoate metabolic process http://purl.obolibrary.org/obo/GO_0046400 GO:0046409 biolink:MolecularActivity p-coumarate 3-hydroxylase activity Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+. go.json cytochrome P450 CYP98A3 http://purl.obolibrary.org/obo/GO_0046409 GO:0046408 biolink:MolecularActivity chlorophyll synthetase activity Catalysis of the reaction: chlorophyllide a + 2 H+ + phytyl diphosphate = chlorophyll a + diphosphate. EC:2.5.1.62|KEGG_REACTION:R06284|MetaCyc:RXN1F-66|RHEA:17317 go.json chlorophyll synthase activity|chlorophyllide-a:phytyl-diphosphate phytyltransferase activity http://purl.obolibrary.org/obo/GO_0046408 GO:0046407 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046407 GO:0046406 biolink:MolecularActivity magnesium protoporphyrin IX methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H+ + magnesium protoporphyrin IX 13-monomethyl ester. EC:2.1.1.11|KEGG_REACTION:R04237|MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN|RHEA:17809 go.json (-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity|Mg-protoporphyrin IX methyltransferase activity|S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity|S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity|S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity|S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity|S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity|magnesium-protoporphyrin O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0046406 GO:0046405 biolink:MolecularActivity glycerol dehydratase activity Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. EC:4.2.1.30|MetaCyc:GLYCEROL-DEHYDRATASE-RXN|RHEA:19765 go.json glycerol dehydrase activity|glycerol hydro-lyase (3-hydroxypropanal-forming)|glycerol hydro-lyase activity http://purl.obolibrary.org/obo/GO_0046405 GO:0046415 biolink:BiologicalProcess urate metabolic process The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. go.json urate metabolism http://purl.obolibrary.org/obo/GO_0046415 GO:0046414 biolink:BiologicalProcess organomercury biosynthetic process The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom. go.json organomercury anabolism|organomercury biosynthesis|organomercury formation|organomercury synthesis http://purl.obolibrary.org/obo/GO_0046414 GO:0046413 biolink:BiologicalProcess organomercury catabolic process The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom. go.json organomercury breakdown|organomercury catabolism|organomercury degradation http://purl.obolibrary.org/obo/GO_0046413 GO:0046412 biolink:BiologicalProcess phenylmercury acetate metabolic process The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. go.json phenylmercury acetate metabolism http://purl.obolibrary.org/obo/GO_0046412 GO:0046411 biolink:BiologicalProcess 2-keto-3-deoxygluconate transmembrane transport The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other. go.json 2-keto-3-deoxygluconate transport http://purl.obolibrary.org/obo/GO_0046411 GO:0046410 biolink:MolecularActivity obsolete 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2. go.json 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity True http://purl.obolibrary.org/obo/GO_0046410 GO:0046419 biolink:BiologicalProcess octopine metabolic process The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine. go.json octopine metabolism http://purl.obolibrary.org/obo/GO_0046419 GO:0046418 biolink:BiologicalProcess nopaline metabolic process The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative. go.json nopaline metabolism http://purl.obolibrary.org/obo/GO_0046418 GO:0046417 biolink:BiologicalProcess chorismate metabolic process The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. go.json chorismate metabolism http://purl.obolibrary.org/obo/GO_0046417 GO:0046416 biolink:BiologicalProcess D-amino acid metabolic process The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids. go.json D-amino acid metabolism http://purl.obolibrary.org/obo/GO_0046416 GO:0046426 biolink:BiologicalProcess negative regulation of receptor signaling pathway via JAK-STAT Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT. go.json down regulation of JAK-STAT cascade|down-regulation of JAK-STAT cascade|downregulation of JAK-STAT cascade|inhibition of JAK-STAT cascade|negative regulation of STAT protein import into nucleus|negative regulation of STAT protein nuclear translocation http://purl.obolibrary.org/obo/GO_0046426 GO:0046425 biolink:BiologicalProcess regulation of receptor signaling pathway via JAK-STAT Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT. go.json STAT protein import into nucleus|regulation of STAT protein import into nucleus|regulation of STAT protein nuclear translocation http://purl.obolibrary.org/obo/GO_0046425 GO:0046424 biolink:MolecularActivity ferulate 5-hydroxylase activity Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+. MetaCyc:RXN-1121 go.json http://purl.obolibrary.org/obo/GO_0046424 GO:0046423 biolink:MolecularActivity allene-oxide cyclase activity Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate. EC:5.3.99.6|KEGG_REACTION:R03402|MetaCyc:ALLENE-OXIDE-CYCLASE-RXN|RHEA:22592 go.json (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing) http://purl.obolibrary.org/obo/GO_0046423 GO:0046422 biolink:MolecularActivity violaxanthin de-epoxidase activity Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O. EC:1.23.5.1|RHEA:32371 go.json VDE|violaxanthin:ascorbate oxidoreductase activity http://purl.obolibrary.org/obo/GO_0046422 GO:0046421 biolink:MolecularActivity methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. EC:4.1.3.30|KEGG_REACTION:R00409|MetaCyc:METHYLISOCITRATE-LYASE-RXN|RHEA:16809 go.json (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)|(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity|2-methylisocitrate lyase activity|MICL http://purl.obolibrary.org/obo/GO_0046421 GO:0046420 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046420 GO:0046429 biolink:MolecularActivity 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. EC:1.17.7.1|KEGG_REACTION:R08689|MetaCyc:RXN0-882|RHEA:26119 go.json (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity|(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity|1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity|1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0046429 GO:0046428 biolink:MolecularActivity 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2. EC:2.5.1.74|MetaCyc:DMK-RXN|RHEA:30099 go.json 1,4-Dihydroxy-2-naphtoate prenyltransferase activity http://purl.obolibrary.org/obo/GO_0046428 GO:0046427 biolink:BiologicalProcess positive regulation of receptor signaling pathway via JAK-STAT Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. go.json activation of JAK-STAT cascade|positive regulation of STAT protein import into nucleus|positive regulation of STAT protein nuclear translocation|stimulation of JAK-STAT cascade|up regulation of JAK-STAT cascade|up-regulation of JAK-STAT cascade|upregulation of JAK-STAT cascade http://purl.obolibrary.org/obo/GO_0046427 GO:1900507 biolink:BiologicalProcess negative regulation of iron-sulfur-molybdenum cofactor assembly Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly. go.json down regulation of FeMoco assembly|down regulation of FeMoco biosynthetic process|down regulation of iron molybdenum cofactor assembly|down regulation of iron molybdenum cofactor biosynthesis|down regulation of iron molybdenum cofactor biosynthetic process|down regulation of iron-sulfur-molybdenum cofactor assembly|down-regulation of FeMoco assembly|down-regulation of FeMoco biosynthetic process|down-regulation of iron molybdenum cofactor assembly|down-regulation of iron molybdenum cofactor biosynthesis|down-regulation of iron molybdenum cofactor biosynthetic process|down-regulation of iron-sulfur-molybdenum cofactor assembly|downregulation of FeMoco assembly|downregulation of FeMoco biosynthetic process|downregulation of iron molybdenum cofactor assembly|downregulation of iron molybdenum cofactor biosynthesis|downregulation of iron molybdenum cofactor biosynthetic process|downregulation of iron-sulfur-molybdenum cofactor assembly|inhibition of FeMoco assembly|inhibition of FeMoco biosynthetic process|inhibition of iron molybdenum cofactor assembly|inhibition of iron molybdenum cofactor biosynthesis|inhibition of iron molybdenum cofactor biosynthetic process|inhibition of iron-sulfur-molybdenum cofactor assembly|negative regulation of FeMoco assembly|negative regulation of FeMoco biosynthetic process|negative regulation of iron molybdenum cofactor assembly|negative regulation of iron molybdenum cofactor biosynthesis|negative regulation of iron molybdenum cofactor biosynthetic process http://purl.obolibrary.org/obo/GO_1900507 GO:1900506 biolink:BiologicalProcess regulation of iron-sulfur-molybdenum cofactor assembly Any process that modulates the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly. go.json regulation of FeMoco assembly|regulation of FeMoco biosynthetic process|regulation of iron molybdenum cofactor assembly|regulation of iron molybdenum cofactor biosynthesis|regulation of iron molybdenum cofactor biosynthetic process http://purl.obolibrary.org/obo/GO_1900506 GO:1900509 biolink:BiologicalProcess regulation of pentose catabolic process to ethanol Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol. go.json regulation of pentose catabolism to ethanol http://purl.obolibrary.org/obo/GO_1900509 GO:1900508 biolink:BiologicalProcess positive regulation of iron-sulfur-molybdenum cofactor assembly Any process that activates or increases the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly. go.json activation of FeMoco assembly|activation of FeMoco biosynthetic process|activation of iron molybdenum cofactor assembly|activation of iron molybdenum cofactor biosynthesis|activation of iron molybdenum cofactor biosynthetic process|activation of iron-sulfur-molybdenum cofactor assembly|positive regulation of FeMoco assembly|positive regulation of FeMoco biosynthetic process|positive regulation of iron molybdenum cofactor assembly|positive regulation of iron molybdenum cofactor biosynthesis|positive regulation of iron molybdenum cofactor biosynthetic process|up regulation of FeMoco assembly|up regulation of FeMoco biosynthetic process|up regulation of iron molybdenum cofactor assembly|up regulation of iron molybdenum cofactor biosynthesis|up regulation of iron molybdenum cofactor biosynthetic process|up regulation of iron-sulfur-molybdenum cofactor assembly|up-regulation of FeMoco assembly|up-regulation of FeMoco biosynthetic process|up-regulation of iron molybdenum cofactor assembly|up-regulation of iron molybdenum cofactor biosynthesis|up-regulation of iron molybdenum cofactor biosynthetic process|up-regulation of iron-sulfur-molybdenum cofactor assembly|upregulation of FeMoco assembly|upregulation of FeMoco biosynthetic process|upregulation of iron molybdenum cofactor assembly|upregulation of iron molybdenum cofactor biosynthesis|upregulation of iron molybdenum cofactor biosynthetic process|upregulation of iron-sulfur-molybdenum cofactor assembly http://purl.obolibrary.org/obo/GO_1900508 GO:1900503 biolink:BiologicalProcess regulation of cellulosome assembly Any process that modulates the frequency, rate or extent of cellulosome assembly. go.json http://purl.obolibrary.org/obo/GO_1900503 GO:1900502 biolink:BiologicalProcess positive regulation of butyryl-CoA catabolic process to butyrate Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. go.json activation of butyryl-CoA catabolic process to butyrate|activation of butyryl-CoA catabolism to butyrate|positive regulation of butyryl-CoA catabolism to butyrate|up regulation of butyryl-CoA catabolic process to butyrate|up regulation of butyryl-CoA catabolism to butyrate|up-regulation of butyryl-CoA catabolic process to butyrate|up-regulation of butyryl-CoA catabolism to butyrate|upregulation of butyryl-CoA catabolic process to butyrate|upregulation of butyryl-CoA catabolism to butyrate http://purl.obolibrary.org/obo/GO_1900502 GO:1900505 biolink:BiologicalProcess positive regulation of cellulosome assembly Any process that activates or increases the frequency, rate or extent of cellulosome assembly. go.json activation of cellulosome assembly|up regulation of cellulosome assembly|up-regulation of cellulosome assembly|upregulation of cellulosome assembly http://purl.obolibrary.org/obo/GO_1900505 GO:1900504 biolink:BiologicalProcess negative regulation of cellulosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly. go.json down regulation of cellulosome assembly|down-regulation of cellulosome assembly|downregulation of cellulosome assembly|inhibition of cellulosome assembly http://purl.obolibrary.org/obo/GO_1900504 GO:0046437 biolink:BiologicalProcess D-amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids. go.json D-amino acid anabolism|D-amino acid biosynthesis|D-amino acid formation|D-amino acid synthesis http://purl.obolibrary.org/obo/GO_0046437 GO:0046436 biolink:BiologicalProcess D-alanine metabolic process The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid. go.json D-alanine metabolism http://purl.obolibrary.org/obo/GO_0046436 GO:0046435 biolink:BiologicalProcess 3-(3-hydroxy)phenylpropionate metabolic process The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. go.json 3-(3-hydroxy)phenylpropionate metabolism http://purl.obolibrary.org/obo/GO_0046435 GO:1900501 biolink:BiologicalProcess negative regulation of butyryl-CoA catabolic process to butyrate Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. go.json down regulation of butyryl-CoA catabolic process to butyrate|down regulation of butyryl-CoA catabolism to butyrate|down-regulation of butyryl-CoA catabolic process to butyrate|down-regulation of butyryl-CoA catabolism to butyrate|downregulation of butyryl-CoA catabolic process to butyrate|downregulation of butyryl-CoA catabolism to butyrate|inhibition of butyryl-CoA catabolic process to butyrate|inhibition of butyryl-CoA catabolism to butyrate|negative regulation of butyryl-CoA catabolism to butyrate http://purl.obolibrary.org/obo/GO_1900501 GO:0046434 biolink:BiologicalProcess organophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. go.json organophosphate breakdown|organophosphate catabolism|organophosphate degradation http://purl.obolibrary.org/obo/GO_0046434 GO:1900500 biolink:BiologicalProcess regulation of butyryl-CoA catabolic process to butyrate Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. go.json regulation of butyryl-CoA catabolism to butyrate http://purl.obolibrary.org/obo/GO_1900500 GO:0046433 biolink:BiologicalProcess 2-aminoethylphosphonate metabolic process The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms. go.json 2-aminoethylphosphonate metabolism|2-phosphonoethylamine metabolic process|2-phosphonoethylamine metabolism|ciliatine metabolic process|ciliatine metabolism http://purl.obolibrary.org/obo/GO_0046433 GO:0046432 biolink:BiologicalProcess 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A. go.json 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism http://purl.obolibrary.org/obo/GO_0046432 GO:0046431 biolink:BiologicalProcess (R)-4-hydroxymandelate metabolic process The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate). go.json (R)-4-hydroxymandelate metabolism http://purl.obolibrary.org/obo/GO_0046431 GO:0046430 biolink:BiologicalProcess non-phosphorylated glucose metabolic process The chemical reactions and pathways involving non-phosphorylated forms of glucose. go.json non-phosphorylated glucose metabolism http://purl.obolibrary.org/obo/GO_0046430 GO:0046439 biolink:BiologicalProcess L-cysteine metabolic process The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. go.json L-cysteine metabolism http://purl.obolibrary.org/obo/GO_0046439 GO:0046438 biolink:BiologicalProcess D-cysteine metabolic process The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin. go.json D-cysteine metabolism http://purl.obolibrary.org/obo/GO_0046438 GO:0022411 biolink:BiologicalProcess cellular component disassembly A cellular process that results in the breakdown of a cellular component. go.json cell structure disassembly|cellular component disassembly at cellular level http://purl.obolibrary.org/obo/GO_0022411 goslim_pir GO:0022410 biolink:BiologicalProcess circadian sleep/wake cycle process A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. go.json http://purl.obolibrary.org/obo/GO_0022410 GO:0022413 biolink:BiologicalProcess reproductive process in single-celled organism A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism. go.json http://purl.obolibrary.org/obo/GO_0022413 GO:0022412 biolink:BiologicalProcess cellular process involved in reproduction in multicellular organism A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. go.json reproductive cellular process in multicellular organism http://purl.obolibrary.org/obo/GO_0022412 GO:0022415 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022415 GO:0022414 biolink:BiologicalProcess reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. go.json single organism reproductive process http://purl.obolibrary.org/obo/GO_0022414 goslim_generic GO:0022417 biolink:BiologicalProcess protein maturation by protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. go.json http://purl.obolibrary.org/obo/GO_0022417 GO:0022416 biolink:BiologicalProcess chaeta development The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. go.json bristle development http://purl.obolibrary.org/obo/GO_0022416 GO:0022400 biolink:BiologicalProcess regulation of rhodopsin mediated signaling pathway Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. go.json regulation of rhodopsin mediated signalling http://purl.obolibrary.org/obo/GO_0022400 GO:0022402 biolink:BiologicalProcess cell cycle process The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. go.json http://purl.obolibrary.org/obo/GO_0022402 gocheck_do_not_annotate GO:0022401 biolink:BiologicalProcess negative adaptation of signaling pathway The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. go.json negative adaptation of signal transduction pathway|negative adaptation of signalling pathway http://purl.obolibrary.org/obo/GO_0022401 GO:0022404 biolink:BiologicalProcess molting cycle process A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin. go.json http://purl.obolibrary.org/obo/GO_0022404 GO:0022403 biolink:BiologicalProcess cell cycle phase One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. go.json http://purl.obolibrary.org/obo/GO_0022403 gocheck_do_not_annotate GO:0022406 biolink:BiologicalProcess membrane docking The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. go.json http://purl.obolibrary.org/obo/GO_0022406 goslim_pir GO:0022405 biolink:BiologicalProcess hair cycle process A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. go.json http://purl.obolibrary.org/obo/GO_0022405 GO:0022408 biolink:BiologicalProcess negative regulation of cell-cell adhesion Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. go.json down regulation of cell-cell adhesion|down-regulation of cell-cell adhesion|downregulation of cell-cell adhesion|inhibition of cell-cell adhesion http://purl.obolibrary.org/obo/GO_0022408 GO:0022407 biolink:BiologicalProcess regulation of cell-cell adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. go.json http://purl.obolibrary.org/obo/GO_0022407 GO:0022409 biolink:BiologicalProcess positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell. go.json activation of cell-cell adhesion|stimulation of cell-cell adhesion|up regulation of cell-cell adhesion|up-regulation of cell-cell adhesion|upregulation of cell-cell adhesion http://purl.obolibrary.org/obo/GO_0022409 GO:0071363 biolink:BiologicalProcess cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. go.json http://purl.obolibrary.org/obo/GO_0071363 GO:0071362 biolink:BiologicalProcess cellular response to ether Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. go.json http://purl.obolibrary.org/obo/GO_0071362 GO:0071361 biolink:BiologicalProcess cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. go.json http://purl.obolibrary.org/obo/GO_0071361 GO:0071360 biolink:BiologicalProcess cellular response to exogenous dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. go.json cellular response to exogenous double-stranded RNA|cellular response to viral dsRNA http://purl.obolibrary.org/obo/GO_0071360 GO:1900477 biolink:BiologicalProcess negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_1900477 GO:1900476 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900476 GO:1900479 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900479 GO:1900478 biolink:BiologicalProcess obsolete positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of sulfate assimilation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json activation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter|activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|activation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter|activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|up regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter|up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|up regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter|up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|up-regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter|up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|up-regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter|up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|upregulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter|upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter|upregulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter|upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900478 GO:1900473 biolink:BiologicalProcess obsolete negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of phosphatidylcholine anabolism by negative regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylcholine biosynthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylcholine formation by negative regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylcholine synthesis by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900473 GO:1900472 biolink:BiologicalProcess obsolete positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json positive regulation of phosphatidylcholine anabolism by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylcholine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylcholine formation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylcholine synthesis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900472 GO:1900475 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900475 GO:1900474 biolink:BiologicalProcess obsolete negative regulation of mating type switching by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_1900474 GO:1900480 biolink:BiologicalProcess regulation of diacylglycerol biosynthetic process Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process. go.json regulation of diacylglycerol anabolism|regulation of diacylglycerol biosynthesis|regulation of diacylglycerol formation|regulation of diacylglycerol synthesis http://purl.obolibrary.org/obo/GO_1900480 GO:1900482 biolink:BiologicalProcess positive regulation of diacylglycerol biosynthetic process Any process that activates or increases the frequency, rate or extent of diacylglycerol biosynthetic process. go.json activation of diacylglycerol anabolism|activation of diacylglycerol biosynthesis|activation of diacylglycerol biosynthetic process|activation of diacylglycerol formation|activation of diacylglycerol synthesis|positive regulation of diacylglycerol anabolism|positive regulation of diacylglycerol biosynthesis|positive regulation of diacylglycerol formation|positive regulation of diacylglycerol synthesis|up regulation of diacylglycerol anabolism|up regulation of diacylglycerol biosynthesis|up regulation of diacylglycerol biosynthetic process|up regulation of diacylglycerol formation|up regulation of diacylglycerol synthesis|up-regulation of diacylglycerol anabolism|up-regulation of diacylglycerol biosynthesis|up-regulation of diacylglycerol biosynthetic process|up-regulation of diacylglycerol formation|up-regulation of diacylglycerol synthesis|upregulation of diacylglycerol anabolism|upregulation of diacylglycerol biosynthesis|upregulation of diacylglycerol biosynthetic process|upregulation of diacylglycerol formation|upregulation of diacylglycerol synthesis http://purl.obolibrary.org/obo/GO_1900482 GO:1900481 biolink:BiologicalProcess negative regulation of diacylglycerol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process. go.json down regulation of diacylglycerol anabolism|down regulation of diacylglycerol biosynthesis|down regulation of diacylglycerol biosynthetic process|down regulation of diacylglycerol formation|down regulation of diacylglycerol synthesis|down-regulation of diacylglycerol anabolism|down-regulation of diacylglycerol biosynthesis|down-regulation of diacylglycerol biosynthetic process|down-regulation of diacylglycerol formation|down-regulation of diacylglycerol synthesis|downregulation of diacylglycerol anabolism|downregulation of diacylglycerol biosynthesis|downregulation of diacylglycerol biosynthetic process|downregulation of diacylglycerol formation|downregulation of diacylglycerol synthesis|inhibition of diacylglycerol anabolism|inhibition of diacylglycerol biosynthesis|inhibition of diacylglycerol biosynthetic process|inhibition of diacylglycerol formation|inhibition of diacylglycerol synthesis|negative regulation of diacylglycerol anabolism|negative regulation of diacylglycerol biosynthesis|negative regulation of diacylglycerol formation|negative regulation of diacylglycerol synthesis http://purl.obolibrary.org/obo/GO_1900481 GO:0071369 biolink:BiologicalProcess cellular response to ethylene stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. go.json cellular response to ethene stimulus http://purl.obolibrary.org/obo/GO_0071369 GO:0071368 biolink:BiologicalProcess cellular response to cytokinin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071368 GO:0071367 biolink:BiologicalProcess cellular response to brassinosteroid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071367 GO:0071366 biolink:BiologicalProcess cellular response to indolebutyric acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus. go.json cellular response to IBA stimulus|cellular response to indole-3-butyric acid stimulus http://purl.obolibrary.org/obo/GO_0071366 GO:0071365 biolink:BiologicalProcess cellular response to auxin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071365 GO:0071364 biolink:BiologicalProcess cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. go.json cellular response to EGF stimulus http://purl.obolibrary.org/obo/GO_0071364 GO:0071352 biolink:BiologicalProcess cellular response to interleukin-2 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. go.json cellular response to IL-2 http://purl.obolibrary.org/obo/GO_0071352 GO:0071351 biolink:BiologicalProcess cellular response to interleukin-18 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. go.json cellular response to IL-18 http://purl.obolibrary.org/obo/GO_0071351 GO:0071350 biolink:BiologicalProcess cellular response to interleukin-15 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. go.json cellular response to IL-15 http://purl.obolibrary.org/obo/GO_0071350 GO:1900488 biolink:BiologicalProcess negative regulation of [2Fe-2S] cluster assembly Any process that stops, prevents or reduces the frequency, rate or extent of [2Fe-2S] cluster assembly. go.json down regulation of 2Fe-2S cluster assembly|down regulation of [2Fe-2S] cluster assembly|down regulation of [2Fe-2S] cluster biosynthetic process|down-regulation of 2Fe-2S cluster assembly|down-regulation of [2Fe-2S] cluster assembly|down-regulation of [2Fe-2S] cluster biosynthetic process|downregulation of 2Fe-2S cluster assembly|downregulation of [2Fe-2S] cluster assembly|downregulation of [2Fe-2S] cluster biosynthetic process|inhibition of 2Fe-2S cluster assembly|inhibition of [2Fe-2S] cluster assembly|inhibition of [2Fe-2S] cluster biosynthetic process|negative regulation of 2Fe-2S cluster assembly|negative regulation of [2Fe-2S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_1900488 GO:1900487 biolink:BiologicalProcess regulation of [2Fe-2S] cluster assembly Any process that modulates the frequency, rate or extent of [2Fe-2S] cluster assembly. go.json regulation of 2Fe-2S cluster assembly|regulation of [2Fe-2S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_1900487 GO:1900489 biolink:BiologicalProcess positive regulation of [2Fe-2S] cluster assembly Any process that activates or increases the frequency, rate or extent of [2Fe-2S] cluster assembly. go.json activation of 2Fe-2S cluster assembly|activation of [2Fe-2S] cluster assembly|activation of [2Fe-2S] cluster biosynthetic process|positive regulation of 2Fe-2S cluster assembly|positive regulation of [2Fe-2S] cluster biosynthetic process|up regulation of 2Fe-2S cluster assembly|up regulation of [2Fe-2S] cluster assembly|up regulation of [2Fe-2S] cluster biosynthetic process|up-regulation of 2Fe-2S cluster assembly|up-regulation of [2Fe-2S] cluster assembly|up-regulation of [2Fe-2S] cluster biosynthetic process|upregulation of 2Fe-2S cluster assembly|upregulation of [2Fe-2S] cluster assembly|upregulation of [2Fe-2S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_1900489 GO:1900484 biolink:BiologicalProcess negative regulation of protein targeting to vacuolar membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane. go.json down regulation of protein targeting to vacuolar membrane|down-regulation of protein targeting to vacuolar membrane|downregulation of protein targeting to vacuolar membrane|inhibition of protein targeting to vacuolar membrane http://purl.obolibrary.org/obo/GO_1900484 GO:1900483 biolink:BiologicalProcess regulation of protein targeting to vacuolar membrane Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_1900483 GO:1900486 biolink:BiologicalProcess positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. go.json activation of Ac-MVA pathway|activation of acetate-mevalonate pathway|activation of isopentenyl diphosphate anabolism, mevalonate pathway|activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|activation of isopentenyl diphosphate formation, mevalonate pathway|activation of isopentenyl diphosphate synthesis, mevalonate pathway|positive regulation of Ac-MVA pathway|positive regulation of acetate-mevalonate pathway|positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway|positive regulation of isopentenyl diphosphate formation, mevalonate pathway|positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway|up regulation of Ac-MVA pathway|up regulation of acetate-mevalonate pathway|up regulation of isopentenyl diphosphate anabolism, mevalonate pathway|up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|up regulation of isopentenyl diphosphate formation, mevalonate pathway|up regulation of isopentenyl diphosphate synthesis, mevalonate pathway|up-regulation of Ac-MVA pathway|up-regulation of acetate-mevalonate pathway|up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway|up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|up-regulation of isopentenyl diphosphate formation, mevalonate pathway|up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway|upregulation of Ac-MVA pathway|upregulation of acetate-mevalonate pathway|upregulation of isopentenyl diphosphate anabolism, mevalonate pathway|upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|upregulation of isopentenyl diphosphate formation, mevalonate pathway|upregulation of isopentenyl diphosphate synthesis, mevalonate pathway http://purl.obolibrary.org/obo/GO_1900486 GO:1900485 biolink:BiologicalProcess positive regulation of protein targeting to vacuolar membrane Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane. go.json activation of protein targeting to vacuolar membrane|up regulation of protein targeting to vacuolar membrane|up-regulation of protein targeting to vacuolar membrane|upregulation of protein targeting to vacuolar membrane http://purl.obolibrary.org/obo/GO_1900485 GO:1900491 biolink:BiologicalProcess regulation of [4Fe-4S] cluster assembly Any process that modulates the frequency, rate or extent of [4Fe-4S] cluster assembly. go.json regulation of 4Fe-4S cluster assembly|regulation of [4Fe-4S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_1900491 GO:1900490 biolink:BiologicalProcess obsolete positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity. go.json activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|activation of HMG-CoA reductase activity|activation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|positive regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|positive regulation of HMG-CoA reductase activity|up regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|up regulation of HMG-CoA reductase activity|up regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|up-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|up-regulation of HMG-CoA reductase activity|up-regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity|upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|upregulation of HMG-CoA reductase activity|upregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity True http://purl.obolibrary.org/obo/GO_1900490 GO:1900493 biolink:BiologicalProcess positive regulation of [4Fe-4S] cluster assembly Any process that activates or increases the frequency, rate or extent of [4Fe-4S] cluster assembly. go.json activation of 4Fe-4S cluster assembly|activation of [4Fe-4S] cluster assembly|activation of [4Fe-4S] cluster biosynthetic process|positive regulation of 4Fe-4S cluster assembly|positive regulation of [4Fe-4S] cluster biosynthetic process|up regulation of 4Fe-4S cluster assembly|up regulation of [4Fe-4S] cluster assembly|up regulation of [4Fe-4S] cluster biosynthetic process|up-regulation of 4Fe-4S cluster assembly|up-regulation of [4Fe-4S] cluster assembly|up-regulation of [4Fe-4S] cluster biosynthetic process|upregulation of 4Fe-4S cluster assembly|upregulation of [4Fe-4S] cluster assembly|upregulation of [4Fe-4S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_1900493 GO:1900492 biolink:BiologicalProcess negative regulation of [4Fe-4S] cluster assembly Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly. go.json down regulation of 4Fe-4S cluster assembly|down regulation of [4Fe-4S] cluster assembly|down regulation of [4Fe-4S] cluster biosynthetic process|down-regulation of 4Fe-4S cluster assembly|down-regulation of [4Fe-4S] cluster assembly|down-regulation of [4Fe-4S] cluster biosynthetic process|downregulation of 4Fe-4S cluster assembly|downregulation of [4Fe-4S] cluster assembly|downregulation of [4Fe-4S] cluster biosynthetic process|inhibition of 4Fe-4S cluster assembly|inhibition of [4Fe-4S] cluster assembly|inhibition of [4Fe-4S] cluster biosynthetic process|negative regulation of 4Fe-4S cluster assembly|negative regulation of [4Fe-4S] cluster biosynthetic process http://purl.obolibrary.org/obo/GO_1900492 GO:0071359 biolink:BiologicalProcess cellular response to dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. go.json cellular response to double-stranded RNA http://purl.obolibrary.org/obo/GO_0071359 GO:0071358 biolink:BiologicalProcess cellular response to type III interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. go.json cellular response to interferon-lambda|cellular response to type III IFN http://purl.obolibrary.org/obo/GO_0071358 GO:0071357 biolink:BiologicalProcess cellular response to type I interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. go.json cellular response to type I IFN http://purl.obolibrary.org/obo/GO_0071357 GO:0071356 biolink:BiologicalProcess cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. go.json cellular response to TNF http://purl.obolibrary.org/obo/GO_0071356 GO:0071355 biolink:BiologicalProcess cellular response to interleukin-9 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. go.json cellular response to IL-9 http://purl.obolibrary.org/obo/GO_0071355 GO:0071354 biolink:BiologicalProcess cellular response to interleukin-6 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. go.json cellular response to IL-6 http://purl.obolibrary.org/obo/GO_0071354 GO:0071353 biolink:BiologicalProcess cellular response to interleukin-4 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. go.json cellular response to IL-4 http://purl.obolibrary.org/obo/GO_0071353 GO:0071385 biolink:BiologicalProcess cellular response to glucocorticoid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. go.json http://purl.obolibrary.org/obo/GO_0071385 GO:0071384 biolink:BiologicalProcess cellular response to corticosteroid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. go.json http://purl.obolibrary.org/obo/GO_0071384 GO:0071383 biolink:BiologicalProcess cellular response to steroid hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071383 GO:0071382 biolink:BiologicalProcess cellular response to prostaglandin I stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus. go.json http://purl.obolibrary.org/obo/GO_0071382 GO:0071381 biolink:BiologicalProcess cellular response to prostaglandin F stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus. go.json http://purl.obolibrary.org/obo/GO_0071381 GO:0071380 biolink:BiologicalProcess cellular response to prostaglandin E stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. go.json http://purl.obolibrary.org/obo/GO_0071380 GO:1900499 biolink:BiologicalProcess positive regulation of butyryl-CoA catabolic process to butanol Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol. go.json activation of butyryl-CoA catabolic process to butanol|activation of butyryl-CoA catabolism to butanol|positive regulation of butyryl-CoA catabolism to butanol|up regulation of butyryl-CoA catabolic process to butanol|up regulation of butyryl-CoA catabolism to butanol|up-regulation of butyryl-CoA catabolic process to butanol|up-regulation of butyryl-CoA catabolism to butanol|upregulation of butyryl-CoA catabolic process to butanol|upregulation of butyryl-CoA catabolism to butanol http://purl.obolibrary.org/obo/GO_1900499 GO:1900498 biolink:BiologicalProcess negative regulation of butyryl-CoA catabolic process to butanol Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol. go.json down regulation of butyryl-CoA catabolic process to butanol|down regulation of butyryl-CoA catabolism to butanol|down-regulation of butyryl-CoA catabolic process to butanol|down-regulation of butyryl-CoA catabolism to butanol|downregulation of butyryl-CoA catabolic process to butanol|downregulation of butyryl-CoA catabolism to butanol|inhibition of butyryl-CoA catabolic process to butanol|inhibition of butyryl-CoA catabolism to butanol|negative regulation of butyryl-CoA catabolism to butanol http://purl.obolibrary.org/obo/GO_1900498 GO:1900495 biolink:BiologicalProcess negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA. go.json down regulation of butyryl-CoA biosynthesis from acetyl-CoA|down regulation of butyryl-CoA biosynthetic process from acetyl-CoA|down-regulation of butyryl-CoA biosynthesis from acetyl-CoA|down-regulation of butyryl-CoA biosynthetic process from acetyl-CoA|downregulation of butyryl-CoA biosynthesis from acetyl-CoA|downregulation of butyryl-CoA biosynthetic process from acetyl-CoA|inhibition of butyryl-CoA biosynthesis from acetyl-CoA|inhibition of butyryl-CoA biosynthetic process from acetyl-CoA|negative regulation of butyryl-CoA biosynthesis from acetyl-CoA http://purl.obolibrary.org/obo/GO_1900495 GO:1900494 biolink:BiologicalProcess regulation of butyryl-CoA biosynthetic process from acetyl-CoA Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA. go.json regulation of butyryl-CoA biosynthesis from acetyl-CoA http://purl.obolibrary.org/obo/GO_1900494 GO:1900497 biolink:BiologicalProcess regulation of butyryl-CoA catabolic process to butanol Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol. go.json regulation of butyryl-CoA catabolism to butanol http://purl.obolibrary.org/obo/GO_1900497 GO:1900496 biolink:BiologicalProcess positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA. go.json activation of butyryl-CoA biosynthesis from acetyl-CoA|activation of butyryl-CoA biosynthetic process from acetyl-CoA|positive regulation of butyryl-CoA biosynthesis from acetyl-CoA|up regulation of butyryl-CoA biosynthesis from acetyl-CoA|up regulation of butyryl-CoA biosynthetic process from acetyl-CoA|up-regulation of butyryl-CoA biosynthesis from acetyl-CoA|up-regulation of butyryl-CoA biosynthetic process from acetyl-CoA|upregulation of butyryl-CoA biosynthesis from acetyl-CoA|upregulation of butyryl-CoA biosynthetic process from acetyl-CoA http://purl.obolibrary.org/obo/GO_1900496 GO:0071389 biolink:BiologicalProcess cellular response to mineralocorticoid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. go.json http://purl.obolibrary.org/obo/GO_0071389 GO:0071388 biolink:BiologicalProcess cellular response to cortisone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues. go.json http://purl.obolibrary.org/obo/GO_0071388 GO:0071387 biolink:BiologicalProcess cellular response to cortisol stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. go.json cellular response to hydrocortisone stimulus http://purl.obolibrary.org/obo/GO_0071387 GO:0071386 biolink:BiologicalProcess cellular response to corticosterone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. go.json http://purl.obolibrary.org/obo/GO_0071386 GO:0071374 biolink:BiologicalProcess cellular response to parathyroid hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071374 GO:0071373 biolink:BiologicalProcess cellular response to luteinizing hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071373 GO:0071372 biolink:BiologicalProcess cellular response to follicle-stimulating hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. go.json cellular response to FSH stimulus|cellular response to follicle stimulating hormone stimulus http://purl.obolibrary.org/obo/GO_0071372 GO:0071371 biolink:BiologicalProcess cellular response to gonadotropin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. go.json cellular response to gonadotrophin stimulus http://purl.obolibrary.org/obo/GO_0071371 GO:0071370 biolink:BiologicalProcess cellular response to gibberellin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. go.json cellular response to gibberellic acid stimulus http://purl.obolibrary.org/obo/GO_0071370 GO:0071379 biolink:BiologicalProcess cellular response to prostaglandin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071379 GO:0071378 biolink:BiologicalProcess cellular response to growth hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. go.json http://purl.obolibrary.org/obo/GO_0071378 GO:0071377 biolink:BiologicalProcess cellular response to glucagon stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. go.json http://purl.obolibrary.org/obo/GO_0071377 GO:0071376 biolink:BiologicalProcess cellular response to corticotropin-releasing hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. go.json cellular response to CRF stimulus|cellular response to CRH stimulus|cellular response to corticoliberin stimulus|cellular response to corticotropin-releasing factor stimulus http://purl.obolibrary.org/obo/GO_0071376 GO:0071375 biolink:BiologicalProcess cellular response to peptide hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. go.json cellular response to polypeptide hormone stimulus http://purl.obolibrary.org/obo/GO_0071375 GO:0071396 biolink:BiologicalProcess cellular response to lipid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071396 GO:0071395 biolink:BiologicalProcess cellular response to jasmonic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071395 GO:0071394 biolink:BiologicalProcess cellular response to testosterone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071394 GO:0071393 biolink:BiologicalProcess cellular response to progesterone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071393 GO:0071392 biolink:BiologicalProcess cellular response to estradiol stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. go.json cellular response to E2 stimulus http://purl.obolibrary.org/obo/GO_0071392 GO:0071391 biolink:BiologicalProcess cellular response to estrogen stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. go.json cellular response to 17alpha-ethynylestradiol|cellular response to oestrogen stimulus http://purl.obolibrary.org/obo/GO_0071391 GO:0071390 biolink:BiologicalProcess cellular response to ecdysone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071390 GO:0071399 biolink:BiologicalProcess cellular response to linoleic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus. go.json cellular response to linoleate http://purl.obolibrary.org/obo/GO_0071399 GO:0071398 biolink:BiologicalProcess cellular response to fatty acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071398 GO:0071397 biolink:BiologicalProcess cellular response to cholesterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. go.json http://purl.obolibrary.org/obo/GO_0071397 GO:0046327 biolink:BiologicalProcess glycerol biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate. go.json glycerol anabolism from pyruvate|glycerol formation from pyruvate|glycerol synthesis from pyruvate|glyceroneogenesis http://purl.obolibrary.org/obo/GO_0046327 GO:0046326 biolink:BiologicalProcess positive regulation of glucose import Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. go.json activation of glucose import|positive regulation of glucose uptake|stimulation of glucose import|up regulation of glucose import|up-regulation of glucose import|upregulation of glucose import http://purl.obolibrary.org/obo/GO_0046326 GO:0046325 biolink:BiologicalProcess negative regulation of glucose import Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. go.json down regulation of glucose import|down-regulation of glucose import|downregulation of glucose import|inhibition of glucose import|negative regulation of glucose uptake http://purl.obolibrary.org/obo/GO_0046325 GO:0046324 biolink:BiologicalProcess regulation of glucose import Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. go.json regulation of glucose uptake http://purl.obolibrary.org/obo/GO_0046324 GO:0046323 biolink:BiologicalProcess glucose import The directed movement of the hexose monosaccharide glucose into a cell or organelle. Wikipedia:Glucose_uptake go.json glucose uptake http://purl.obolibrary.org/obo/GO_0046323 GO:0046322 biolink:BiologicalProcess negative regulation of fatty acid oxidation Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation. go.json down regulation of fatty acid oxidation|down-regulation of fatty acid oxidation|downregulation of fatty acid oxidation|inhibition of fatty acid oxidation http://purl.obolibrary.org/obo/GO_0046322 GO:0046321 biolink:BiologicalProcess positive regulation of fatty acid oxidation Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. go.json activation of fatty acid oxidation|stimulation of fatty acid oxidation|up regulation of fatty acid oxidation|up-regulation of fatty acid oxidation|upregulation of fatty acid oxidation http://purl.obolibrary.org/obo/GO_0046321 GO:0046320 biolink:BiologicalProcess regulation of fatty acid oxidation Any process that modulates the frequency, rate or extent of fatty acid oxidation. go.json http://purl.obolibrary.org/obo/GO_0046320 GO:0061960 biolink:BiologicalProcess regulation of heme oxygenase activity Any process that modulates the frequency, or rate of heme oxygenase activity. go.json http://purl.obolibrary.org/obo/GO_0061960 gocheck_do_not_annotate GO:0061962 biolink:BiologicalProcess negative regulation of heme oxygenase activity Any process that stops, prevents, or reduces the frequency or rate of heme oxygenase activity. go.json http://purl.obolibrary.org/obo/GO_0061962 gocheck_do_not_annotate GO:0061961 biolink:BiologicalProcess positive regulation of heme oxygenase activity Any process that activates or increases the frequency or rate of heme oxygenase activity. go.json http://purl.obolibrary.org/obo/GO_0061961 gocheck_do_not_annotate GO:0061964 biolink:BiologicalProcess negative regulation of entry into reproductive diapause Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. go.json http://purl.obolibrary.org/obo/GO_0061964 GO:0061963 biolink:BiologicalProcess regulation of entry into reproductive diapause Any process that modulates the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. go.json http://purl.obolibrary.org/obo/GO_0061963 GO:0046329 biolink:BiologicalProcess negative regulation of JNK cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. go.json down regulation of JNK cascade|down-regulation of JNK cascade|downregulation of JNK cascade|inhibition of JNK cascade http://purl.obolibrary.org/obo/GO_0046329 GO:0061966 biolink:BiologicalProcess establishment of left/right asymmetry The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0061966 GO:0061965 biolink:BiologicalProcess positive regulation of entry into reproductive diapause Any process that activates or increases the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. go.json http://purl.obolibrary.org/obo/GO_0061965 GO:0046328 biolink:BiologicalProcess regulation of JNK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. go.json regulation of SAPK cascade http://purl.obolibrary.org/obo/GO_0046328 GO:0061968 biolink:BiologicalProcess maintenance of left/right asymmetry The organization process that preserves the asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0061968 GO:0061967 biolink:BiologicalProcess establishment of left sidedness The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side. go.json http://purl.obolibrary.org/obo/GO_0061967 GO:0061969 biolink:BiologicalProcess maintenance of left sidedness The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0061969 GO:1900408 biolink:BiologicalProcess negative regulation of cellular response to oxidative stress Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. go.json down regulation of adaptive response to oxidative stress|down regulation of cellular response to oxidative stress|down-regulation of adaptive response to oxidative stress|down-regulation of cellular response to oxidative stress|downregulation of adaptive response to oxidative stress|downregulation of cellular response to oxidative stress|inhibition of adaptive response to oxidative stress|inhibition of cellular response to oxidative stress|negative regulation of adaptive response to oxidative stress http://purl.obolibrary.org/obo/GO_1900408 GO:0046330 biolink:BiologicalProcess positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. go.json activation of JNK cascade|stimulation of JNK cascade|up regulation of JNK cascade|up-regulation of JNK cascade|upregulation of JNK cascade http://purl.obolibrary.org/obo/GO_0046330 GO:1900407 biolink:BiologicalProcess regulation of cellular response to oxidative stress Any process that modulates the frequency, rate or extent of cellular response to oxidative stress. go.json regulation of adaptive response to oxidative stress http://purl.obolibrary.org/obo/GO_1900407 GO:1900409 biolink:BiologicalProcess positive regulation of cellular response to oxidative stress Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress. go.json activation of adaptive response to oxidative stress|activation of cellular response to oxidative stress|positive regulation of adaptive response to oxidative stress|up regulation of adaptive response to oxidative stress|up regulation of cellular response to oxidative stress|up-regulation of adaptive response to oxidative stress|up-regulation of cellular response to oxidative stress|upregulation of adaptive response to oxidative stress|upregulation of cellular response to oxidative stress http://purl.obolibrary.org/obo/GO_1900409 GO:1900404 biolink:BiologicalProcess obsolete positive regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of DNA repair. go.json activation of DNA repair by positive regulation of transcription from RNA polymerase II promoter|stimulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter|up regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter|up-regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter|upregulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900404 GO:1900403 biolink:BiologicalProcess obsolete negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cellular amino acid biosynthetic process. go.json negative regulation of amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter|negative regulation of cellular amino acid anabolism by negative regulation of transcription from RNA polymerase II promoter|negative regulation of cellular amino acid biosynthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of cellular amino acid formation by negative regulation of transcription from RNA polymerase II promoter|negative regulation of cellular amino acid synthesis by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900403 GO:1900406 biolink:BiologicalProcess obsolete regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of conjugation with cellular fusion. go.json True http://purl.obolibrary.org/obo/GO_1900406 GO:1900405 biolink:BiologicalProcess obsolete regulation of cell separation after cytokinesis by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cell separation after cytokinesis. go.json regulation of cytokinetic cell separation by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900405 GO:0046338 biolink:BiologicalProcess phosphatidylethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. go.json phosphatidylethanolamine breakdown|phosphatidylethanolamine catabolism|phosphatidylethanolamine degradation http://purl.obolibrary.org/obo/GO_0046338 GO:1900400 biolink:BiologicalProcess obsolete regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import. go.json regulation of iron import by regulation of transcription from RNA polymerase II promoter|regulation of iron ion import by regulation of transcription from RNA polymerase II promoter|regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900400 GO:0046337 biolink:BiologicalProcess phosphatidylethanolamine metabolic process The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. go.json phosphatidylethanolamine metabolism http://purl.obolibrary.org/obo/GO_0046337 GO:0046336 biolink:BiologicalProcess ethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). go.json ethanolamine breakdown|ethanolamine catabolism|ethanolamine degradation http://purl.obolibrary.org/obo/GO_0046336 GO:1900402 biolink:BiologicalProcess obsolete regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate metabolic process. go.json regulation of carbohydrate metabolism by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900402 GO:0046335 biolink:BiologicalProcess ethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). go.json ethanolamine anabolism|ethanolamine biosynthesis|ethanolamine formation|ethanolamine synthesis http://purl.obolibrary.org/obo/GO_0046335 GO:1900401 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900401 GO:0046334 biolink:BiologicalProcess octopamine catabolic process The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. go.json octopamine breakdown|octopamine catabolism|octopamine degradation http://purl.obolibrary.org/obo/GO_0046334 GO:0046333 biolink:BiologicalProcess octopamine metabolic process The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. go.json octopamine metabolism http://purl.obolibrary.org/obo/GO_0046333 GO:0046332 biolink:MolecularActivity SMAD binding Binding to a SMAD signaling protein. go.json http://purl.obolibrary.org/obo/GO_0046332 GO:0046331 biolink:BiologicalProcess lateral inhibition Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells. go.json http://purl.obolibrary.org/obo/GO_0046331 GO:0061951 biolink:BiologicalProcess establishment of protein localization to plasma membrane The directed movement of a protein to a specific location in a plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0061951 GO:0061950 biolink:BiologicalProcess negative regulation of premature acrosome loss Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. go.json negative regulation of spontaneous acrosome loss http://purl.obolibrary.org/obo/GO_0061950 GO:0061953 biolink:MolecularActivity mRNA (adenine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA. go.json http://purl.obolibrary.org/obo/GO_0061953 GO:0061952 biolink:BiologicalProcess midbody abscission The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells. go.json cell separation during cytokinesis|cytokinetic abscission http://purl.obolibrary.org/obo/GO_0061952 GO:0061955 biolink:BiologicalProcess obsolete positive regulation of actin filament depolymerization involved in acrosome reaction OBSOLETE. Any process that increases the rate or exent of actin depolymerization as part of the acrosome reaction. This allows the acrosomal membrane and plasma membrane to fuse. go.json True http://purl.obolibrary.org/obo/GO_0061955 GO:0046339 biolink:BiologicalProcess diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. go.json diacylglycerol metabolism|diglyceride metabolism http://purl.obolibrary.org/obo/GO_0046339 GO:0061954 biolink:BiologicalProcess obsolete positive regulation of actin filament polymerization involved in sperm capacitation OBSOLETE. Any process that icreases the rate or extent of actin polymerization as part of sperm capacitation. This process prevents a spontaneous acrosome reaction. go.json True http://purl.obolibrary.org/obo/GO_0061954 GO:0061957 biolink:CellularComponent NVT complex A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1. go.json http://purl.obolibrary.org/obo/GO_0061957 GO:0061956 biolink:BiologicalProcess penetration of cumulus oophorus The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. go.json penetration of cumulus cells layer|penetration of cumulus mass http://purl.obolibrary.org/obo/GO_0061956 GO:0061959 biolink:BiologicalProcess response to (R)-carnitine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus. go.json response to L-carnitine http://purl.obolibrary.org/obo/GO_0061959 GO:0046341 biolink:BiologicalProcess CDP-diacylglycerol metabolic process The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. go.json CDP-diacylglycerol metabolism http://purl.obolibrary.org/obo/GO_0046341 GO:1900419 biolink:BiologicalProcess regulation of cellular alcohol catabolic process Any process that modulates the frequency, rate or extent of cellular alcohol catabolic process. go.json http://purl.obolibrary.org/obo/GO_1900419 GO:1900418 biolink:BiologicalProcess obsolete positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of purine nucleotide biosynthetic process. go.json activation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter|activation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter|activation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|activation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter|activation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter|positive regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter|up regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter|up regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter|up-regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter|up-regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter|upregulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter|upregulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900418 GO:0046340 biolink:BiologicalProcess diacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. go.json diacylglycerol breakdown|diacylglycerol catabolism|diacylglycerol degradation|diglyceride catabolism http://purl.obolibrary.org/obo/GO_0046340 GO:1900415 biolink:BiologicalProcess obsolete regulation of fungal-type cell wall biogenesis by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of fungal-type cell wall biogenesis. go.json regulation of chitin- and beta-glucan-containing cell wall biogenesis by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900415 GO:1900414 biolink:BiologicalProcess obsolete regulation of cytokinesis by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cytokinesis. go.json True http://purl.obolibrary.org/obo/GO_1900414 GO:1900417 biolink:BiologicalProcess obsolete negative regulation of transmembrane transport by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of transmembrane transport. go.json True http://purl.obolibrary.org/obo/GO_1900417 GO:1900416 biolink:BiologicalProcess obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of 4,6-pyruvylated galactose residue biosynthetic process. go.json True http://purl.obolibrary.org/obo/GO_1900416 GO:0046349 biolink:BiologicalProcess amino sugar biosynthetic process The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. go.json amino sugar anabolism|amino sugar biosynthesis|amino sugar formation|amino sugar synthesis|aminosaccharide biosynthesis|aminosaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0046349 GO:1900411 biolink:BiologicalProcess obsolete regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone acetylation. go.json True http://purl.obolibrary.org/obo/GO_1900411 GO:0046348 biolink:BiologicalProcess amino sugar catabolic process The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. go.json amino sugar breakdown|amino sugar catabolism|amino sugar degradation|aminosaccharide catabolic process|aminosaccharide catabolism http://purl.obolibrary.org/obo/GO_0046348 GO:1900410 biolink:BiologicalProcess obsolete regulation of histone modification by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone modification. go.json True http://purl.obolibrary.org/obo/GO_1900410 GO:1900413 biolink:BiologicalProcess obsolete positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of phospholipid biosynthetic process. go.json positive regulation of phospholipid biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phospholipid synthesis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900413 GO:0046347 biolink:BiologicalProcess mannosamine biosynthetic process The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. go.json mannosamine anabolism|mannosamine biosynthesis|mannosamine formation|mannosamine synthesis http://purl.obolibrary.org/obo/GO_0046347 GO:0046346 biolink:BiologicalProcess mannosamine catabolic process The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. go.json mannosamine breakdown|mannosamine catabolism|mannosamine degradation http://purl.obolibrary.org/obo/GO_0046346 GO:1900412 biolink:BiologicalProcess obsolete regulation of histone methylation by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone methylation. go.json True http://purl.obolibrary.org/obo/GO_1900412 GO:0046345 biolink:BiologicalProcess abscisic acid catabolic process The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. go.json abscisic acid breakdown|abscisic acid catabolism|abscisic acid degradation http://purl.obolibrary.org/obo/GO_0046345 GO:0046344 biolink:BiologicalProcess ecdysteroid catabolic process The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. go.json ecdysteroid breakdown|ecdysteroid catabolism|ecdysteroid degradation http://purl.obolibrary.org/obo/GO_0046344 GO:0061980 biolink:MolecularActivity regulatory RNA binding Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme. go.json http://purl.obolibrary.org/obo/GO_0061980 GO:0046343 biolink:BiologicalProcess streptomycin metabolic process The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. go.json streptomycin metabolism http://purl.obolibrary.org/obo/GO_0046343 GO:0046342 biolink:BiologicalProcess CDP-diacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. go.json CDP-diacylglycerol breakdown|CDP-diacylglycerol catabolism|CDP-diacylglycerol degradation http://purl.obolibrary.org/obo/GO_0046342 GO:0061982 biolink:BiologicalProcess meiosis I cell cycle process A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs. go.json first meiotic cell division http://purl.obolibrary.org/obo/GO_0061982 GO:0061981 biolink:MolecularActivity 3-hydroxykynureninase activity Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. RHEA:25143 go.json http://purl.obolibrary.org/obo/GO_0061981 GO:0061984 biolink:BiologicalProcess catabolite repression A process in which the presence of one nutrient source leads to a decrease in the frequency, rate, or extent of processes involved in the metabolism of other nutrient sources. go.json http://purl.obolibrary.org/obo/GO_0061984 GO:0061983 biolink:BiologicalProcess meiosis II cell cycle process A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes. go.json second meiotic division http://purl.obolibrary.org/obo/GO_0061983 GO:0071309 biolink:BiologicalProcess cellular response to phylloquinone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus. go.json cellular response to vitamin K1 http://purl.obolibrary.org/obo/GO_0071309 GO:0061986 biolink:BiologicalProcess negative regulation of transcription by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription. go.json http://purl.obolibrary.org/obo/GO_0061986 GO:0071308 biolink:BiologicalProcess cellular response to menaquinone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus. go.json cellular response to menatetrenone|cellular response to vitamin K2 http://purl.obolibrary.org/obo/GO_0071308 GO:0061985 biolink:BiologicalProcess carbon catabolite repression A process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of the metabolism of other carbon sources. go.json http://purl.obolibrary.org/obo/GO_0061985 GO:0071307 biolink:BiologicalProcess cellular response to vitamin K Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. go.json http://purl.obolibrary.org/obo/GO_0071307 GO:0061988 biolink:BiologicalProcess karyosome formation The chromosome organization process in which meiotic chromosomes in the germ cell nucleus cluster together to form a compact spherical structure called the karyosome. go.json http://purl.obolibrary.org/obo/GO_0061988 GO:0071306 biolink:BiologicalProcess cellular response to vitamin E Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. go.json cellular response to DL-alpha-tocopherol acetate|cellular response to DL-alpha-tocopheryl acetate|cellular response to O-Acetyl-alpha-tocopherol http://purl.obolibrary.org/obo/GO_0071306 GO:0061987 biolink:BiologicalProcess negative regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_0061987 GO:0071305 biolink:BiologicalProcess cellular response to vitamin D Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. go.json cellular response to calciferol|cellular response to cholecalciferol|cellular response to ergocalciferol http://purl.obolibrary.org/obo/GO_0071305 GO:0061989 biolink:BiologicalProcess sperm karyosome formation The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome. go.json http://purl.obolibrary.org/obo/GO_0061989 GO:0071304 biolink:BiologicalProcess cellular response to vitamin B6 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. go.json http://purl.obolibrary.org/obo/GO_0071304 GO:0071303 biolink:BiologicalProcess cellular response to vitamin B3 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus. go.json cellular response to niacin|cellular response to nicotinamide http://purl.obolibrary.org/obo/GO_0071303 GO:0071302 biolink:BiologicalProcess cellular response to vitamin B2 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus. go.json cellular response to riboflavin http://purl.obolibrary.org/obo/GO_0071302 GO:0071301 biolink:BiologicalProcess cellular response to vitamin B1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. go.json cellular response to thiamin|cellular response to thiamine http://purl.obolibrary.org/obo/GO_0071301 GO:0071300 biolink:BiologicalProcess cellular response to retinoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. go.json cellular response to vitamin A acid http://purl.obolibrary.org/obo/GO_0071300 GO:0046352 biolink:BiologicalProcess disaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units. go.json disaccharide breakdown|disaccharide catabolism|disaccharide degradation http://purl.obolibrary.org/obo/GO_0046352 GO:0046351 biolink:BiologicalProcess disaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units. go.json disaccharide anabolism|disaccharide biosynthesis|disaccharide formation|disaccharide synthesis http://purl.obolibrary.org/obo/GO_0046351 GO:1900429 biolink:BiologicalProcess negative regulation of filamentous growth of a population of unicellular organisms Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms. go.json down regulation of filamentous growth of a population of unicellular organisms|down-regulation of filamentous growth of a population of unicellular organisms|downregulation of filamentous growth of a population of unicellular organisms|inhibition of filamentous growth of a population of unicellular organisms http://purl.obolibrary.org/obo/GO_1900429 GO:0046350 biolink:BiologicalProcess galactosaminoglycan metabolic process The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose. go.json galactosaminoglycan metabolism http://purl.obolibrary.org/obo/GO_0046350 GO:1900426 biolink:BiologicalProcess positive regulation of defense response to bacterium Any process that activates or increases the frequency, rate or extent of defense response to bacterium. go.json activation of antibacterial peptide activity|activation of defence response to bacteria|activation of defence response to bacterium|activation of defense response to bacteria|activation of defense response to bacterium|activation of resistance response to pathogenic bacteria|activation of resistance response to pathogenic bacterium|positive regulation of antibacterial peptide activity|positive regulation of defence response to bacteria|positive regulation of defence response to bacterium|positive regulation of defense response to bacteria|positive regulation of defense response to bacterium, incompatible interaction|up regulation of antibacterial peptide activity|up regulation of defence response to bacteria|up regulation of defence response to bacterium|up regulation of defense response to bacteria|up regulation of defense response to bacterium|up-regulation of antibacterial peptide activity|up-regulation of defence response to bacteria|up-regulation of defence response to bacterium|up-regulation of defense response to bacteria|up-regulation of defense response to bacterium|upregulation of antibacterial peptide activity|upregulation of defence response to bacteria|upregulation of defence response to bacterium|upregulation of defense response to bacteria|upregulation of defense response to bacterium http://purl.obolibrary.org/obo/GO_1900426 GO:1900425 biolink:BiologicalProcess negative regulation of defense response to bacterium Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. go.json down regulation of antibacterial peptide activity|down regulation of defence response to bacteria|down regulation of defence response to bacterium|down regulation of defense response to bacteria|down regulation of defense response to bacterium|down-regulation of antibacterial peptide activity|down-regulation of defence response to bacteria|down-regulation of defence response to bacterium|down-regulation of defense response to bacteria|down-regulation of defense response to bacterium|downregulation of antibacterial peptide activity|downregulation of defence response to bacteria|downregulation of defence response to bacterium|downregulation of defense response to bacteria|downregulation of defense response to bacterium|inhibition of antibacterial peptide activity|inhibition of defence response to bacteria|inhibition of defence response to bacterium|inhibition of defence response to pathogenic bacteria, incompatible interaction|inhibition of defence response to pathogenic bacterium, incompatible interaction|inhibition of defense response to bacteria|inhibition of defense response to bacterium|inhibition of defense response to bacterium, incompatible interaction|inhibition of resistance response to pathogenic bacteria|inhibition of resistance response to pathogenic bacterium|inhibition of response to pathogenic bacteria (incompatible interaction)|inhibition of response to pathogenic bacterium (incompatible interaction)|negative regulation of antibacterial peptide activity|negative regulation of defence response to bacteria|negative regulation of defence response to bacterium|negative regulation of defense response to bacteria|negative regulation of defense response to bacterium, incompatible interaction http://purl.obolibrary.org/obo/GO_1900425 GO:1900428 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms. go.json http://purl.obolibrary.org/obo/GO_1900428 GO:1900427 biolink:BiologicalProcess obsolete regulation of cellular response to oxidative stress by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cellular response to oxidative stress. go.json regulation of adaptive response to oxidative stress by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900427 GO:1900422 biolink:BiologicalProcess obsolete positive regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of cellular alcohol catabolic process. go.json activation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900422 GO:0046359 biolink:BiologicalProcess butyrate catabolic process The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid. go.json butanoic acid breakdown|butanoic acid catabolic process|butanoic acid catabolism|butanoic acid degradation|butyrate breakdown|butyrate catabolism|butyrate degradation http://purl.obolibrary.org/obo/GO_0046359 GO:1900421 biolink:BiologicalProcess positive regulation of cellular alcohol catabolic process Any process that activates or increases the frequency, rate or extent of cellular alcohol catabolic process. go.json activation of cellular alcohol catabolic process|up regulation of cellular alcohol catabolic process|up-regulation of cellular alcohol catabolic process|upregulation of cellular alcohol catabolic process http://purl.obolibrary.org/obo/GO_1900421 GO:1900424 biolink:BiologicalProcess regulation of defense response to bacterium Any process that modulates the frequency, rate or extent of defense response to bacterium. go.json regulation of antibacterial peptide activity|regulation of defence response to bacteria|regulation of defence response to bacterium|regulation of defence response to bacterium, incompatible interaction|regulation of defence response to pathogenic bacteria, incompatible interaction|regulation of defence response to pathogenic bacterium, incompatible interaction|regulation of defense response to bacteria|regulation of defense response to bacterium, incompatible interaction|regulation of resistance response to pathogenic bacteria|regulation of resistance response to pathogenic bacterium http://purl.obolibrary.org/obo/GO_1900424 GO:0046358 biolink:BiologicalProcess butyrate biosynthetic process The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid. go.json butanoic acid anabolism|butanoic acid biosynthesis|butanoic acid biosynthetic process|butanoic acid formation|butanoic acid synthesis|butyrate anabolism|butyrate biosynthesis|butyrate formation|butyrate synthesis http://purl.obolibrary.org/obo/GO_0046358 GO:1900423 biolink:BiologicalProcess obsolete positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching. go.json activation of mating type switching by positive regulation of transcription from RNA polymerase II promoter|stimulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter|up regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter|up-regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter|upregulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900423 GO:0046357 biolink:BiologicalProcess galactarate biosynthetic process The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid. go.json D-galactarate anabolism|D-galactarate biosynthesis|D-galactarate biosynthetic process|D-galactarate formation|D-galactarate synthesis|galactarate anabolism|galactarate biosynthesis|galactarate formation|galactarate synthesis http://purl.obolibrary.org/obo/GO_0046357 GO:0046356 biolink:BiologicalProcess acetyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. go.json acetyl-CoA breakdown|acetyl-CoA catabolism|acetyl-CoA degradation http://purl.obolibrary.org/obo/GO_0046356 GO:0046355 biolink:BiologicalProcess mannan catabolic process The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. go.json mannan breakdown|mannan catabolism|mannan degradation http://purl.obolibrary.org/obo/GO_0046355 GO:1900420 biolink:BiologicalProcess negative regulation of cellular alcohol catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellular alcohol catabolic process. go.json down regulation of cellular alcohol catabolic process|down-regulation of cellular alcohol catabolic process|downregulation of cellular alcohol catabolic process|inhibition of cellular alcohol catabolic process http://purl.obolibrary.org/obo/GO_1900420 GO:0046354 biolink:BiologicalProcess mannan biosynthetic process The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. go.json mannan anabolism|mannan biosynthesis|mannan formation|mannan synthesis http://purl.obolibrary.org/obo/GO_0046354 GO:0046353 biolink:MolecularActivity aminoglycoside 3-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring. EC:2.3.1.60|EC:2.3.1.81|MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN|MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN go.json 3'-aminoglycoside acetyltransferase activity|3-N-aminoglycoside acetyltransferase activity|acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity|acetyl-CoA:gentamicin-C N3'-acetyltransferase activity|aminoglycoside acetyltransferase AAC(3)-1|aminoglycoside acetyltransferase AAC(3)-I activity|gentamicin 3'-N-acetyltransferase activity|gentamicin acetyltransferase I activity|gentamicin-(3)-N-acetyltransferase activity|gentamycin 3'-N-acetyltransferase activity|gentamycin acetyltransferase I http://purl.obolibrary.org/obo/GO_0046353 GO:0061971 biolink:BiologicalProcess replacement bone morphogenesis The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. go.json http://purl.obolibrary.org/obo/GO_0061971 GO:0061970 biolink:BiologicalProcess maintenance of right sidedness The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves. go.json http://purl.obolibrary.org/obo/GO_0061970 GO:0061973 biolink:BiologicalProcess membrane bone morphogenesis The process in which bone which forms deep in the organism are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061973 GO:0061972 biolink:BiologicalProcess dermal bone morphogenesis The process in which bone which forms superficially in the organism are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0061972 GO:0061975 biolink:BiologicalProcess articular cartilage development The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure. go.json articular cartilage of joint development http://purl.obolibrary.org/obo/GO_0061975 GO:0061974 biolink:BiologicalProcess perichondral bone morphogenesis The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone. go.json http://purl.obolibrary.org/obo/GO_0061974 GO:0061977 biolink:BiologicalProcess hip joint articular cartilage development The process whose specific outcome is the progression of hip joint articular cartilage over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061977 GO:0061976 biolink:BiologicalProcess temporomandibular joint articular cartilage development The process whose specific outcome is the progression of temporomandibular joint articular cartilage over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061976 GO:0061979 biolink:BiologicalProcess femoral head articular cartilage development The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061979 GO:0061978 biolink:BiologicalProcess mandibular condyle articular cartilage development The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0061978 GO:0046363 biolink:BiologicalProcess ribitol catabolic process The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. go.json ribitol breakdown|ribitol catabolism|ribitol degradation http://purl.obolibrary.org/obo/GO_0046363 GO:0046362 biolink:BiologicalProcess ribitol biosynthetic process The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. go.json ribitol anabolism|ribitol biosynthesis|ribitol formation|ribitol synthesis http://purl.obolibrary.org/obo/GO_0046362 GO:0046361 biolink:BiologicalProcess 2-oxobutyrate metabolic process The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. go.json 2-oxobutyrate metabolism|alpha-ketobutyrate metabolic process|alpha-ketobutyrate metabolism http://purl.obolibrary.org/obo/GO_0046361 GO:0046360 biolink:BiologicalProcess 2-oxobutyrate biosynthetic process The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. go.json 2-oxobutyrate anabolism|2-oxobutyrate biosynthesis|2-oxobutyrate formation|2-oxobutyrate synthesis|alpha-ketobutyrate biosynthesis|alpha-ketobutyrate biosynthetic process http://purl.obolibrary.org/obo/GO_0046360 GO:1900437 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. go.json http://purl.obolibrary.org/obo/GO_1900437 GO:1900436 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation. go.json activation of filamentous growth of a population of unicellular organisms in response to starvation|up regulation of filamentous growth of a population of unicellular organisms in response to starvation|up-regulation of filamentous growth of a population of unicellular organisms in response to starvation|upregulation of filamentous growth of a population of unicellular organisms in response to starvation http://purl.obolibrary.org/obo/GO_1900436 GO:1900439 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. go.json activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus http://purl.obolibrary.org/obo/GO_1900439 GO:1900438 biolink:BiologicalProcess negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. go.json down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus http://purl.obolibrary.org/obo/GO_1900438 GO:1900433 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms in response to heat Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat. go.json activation of filamentous growth of a population of unicellular organisms in response to heat|up regulation of filamentous growth of a population of unicellular organisms in response to heat|up-regulation of filamentous growth of a population of unicellular organisms in response to heat|upregulation of filamentous growth of a population of unicellular organisms in response to heat http://purl.obolibrary.org/obo/GO_1900433 GO:1900432 biolink:BiologicalProcess negative regulation of filamentous growth of a population of unicellular organisms in response to heat Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat. go.json down regulation of filamentous growth of a population of unicellular organisms in response to heat|down-regulation of filamentous growth of a population of unicellular organisms in response to heat|downregulation of filamentous growth of a population of unicellular organisms in response to heat|inhibition of filamentous growth of a population of unicellular organisms in response to heat http://purl.obolibrary.org/obo/GO_1900432 GO:1900435 biolink:BiologicalProcess obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation. go.json down regulation of filamentous growth of a population of unicellular organisms in response to starvation|down-regulation of filamentous growth of a population of unicellular organisms in response to starvation|downregulation of filamentous growth of a population of unicellular organisms in response to starvation|inhibition of filamentous growth of a population of unicellular organisms in response to starvation True http://purl.obolibrary.org/obo/GO_1900435 GO:0046369 biolink:BiologicalProcess galactose biosynthetic process The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose. go.json galactose anabolism|galactose biosynthesis|galactose formation|galactose synthesis http://purl.obolibrary.org/obo/GO_0046369 GO:1900434 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms in response to starvation Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation. go.json http://purl.obolibrary.org/obo/GO_1900434 GO:0046368 biolink:BiologicalProcess GDP-L-fucose metabolic process The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. go.json GDP-L-fucose metabolism http://purl.obolibrary.org/obo/GO_0046368 GO:0046367 biolink:BiologicalProcess allose catabolic process The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. go.json allose breakdown|allose catabolism|allose degradation http://purl.obolibrary.org/obo/GO_0046367 GO:0046366 biolink:BiologicalProcess allose biosynthetic process The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. go.json allose anabolism|allose biosynthesis|allose formation|allose synthesis http://purl.obolibrary.org/obo/GO_0046366 GO:0046365 biolink:BiologicalProcess monosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. go.json monosaccharide breakdown|monosaccharide catabolism|monosaccharide degradation http://purl.obolibrary.org/obo/GO_0046365 GO:1900431 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms in response to heat Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat. go.json http://purl.obolibrary.org/obo/GO_1900431 GO:1900430 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms. go.json activation of filamentous growth of a population of unicellular organisms|up regulation of filamentous growth of a population of unicellular organisms|up-regulation of filamentous growth of a population of unicellular organisms|upregulation of filamentous growth of a population of unicellular organisms http://purl.obolibrary.org/obo/GO_1900430 GO:0046364 biolink:BiologicalProcess monosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. go.json monosaccharide anabolism|monosaccharide biosynthesis|monosaccharide formation|monosaccharide synthesis http://purl.obolibrary.org/obo/GO_0046364 GO:0071329 biolink:BiologicalProcess cellular response to sucrose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. go.json http://purl.obolibrary.org/obo/GO_0071329 GO:0071328 biolink:BiologicalProcess cellular response to maltose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus. go.json http://purl.obolibrary.org/obo/GO_0071328 GO:0071327 biolink:BiologicalProcess cellular response to trehalose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus. go.json http://purl.obolibrary.org/obo/GO_0071327 GO:0071326 biolink:BiologicalProcess cellular response to monosaccharide stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. go.json http://purl.obolibrary.org/obo/GO_0071326 GO:0071325 biolink:BiologicalProcess cellular response to mannitol stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus. go.json http://purl.obolibrary.org/obo/GO_0071325 GO:0071324 biolink:BiologicalProcess cellular response to disaccharide stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. go.json http://purl.obolibrary.org/obo/GO_0071324 GO:0071323 biolink:BiologicalProcess cellular response to chitin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071323 GO:0071322 biolink:BiologicalProcess cellular response to carbohydrate stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. go.json http://purl.obolibrary.org/obo/GO_0071322 GO:0071321 biolink:BiologicalProcess cellular response to cGMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. go.json cellular response to 3',5' cGMP|cellular response to 3',5'-cGMP|cellular response to cyclic GMP|cellular response to guanosine 3',5'-cyclophosphate http://purl.obolibrary.org/obo/GO_0071321 GO:0071320 biolink:BiologicalProcess cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. go.json cellular response to 3',5' cAMP|cellular response to 3',5'-cAMP|cellular response to adenosine 3',5'-cyclophosphate|cellular response to cyclic AMP http://purl.obolibrary.org/obo/GO_0071320 GO:0046374 biolink:BiologicalProcess teichoic acid metabolic process The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. go.json teichoic acid metabolism http://purl.obolibrary.org/obo/GO_0046374 GO:0046373 biolink:BiologicalProcess L-arabinose metabolic process The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc. go.json L-arabinose metabolism http://purl.obolibrary.org/obo/GO_0046373 GO:0046372 biolink:BiologicalProcess D-arabinose metabolic process The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides. go.json D-arabinose metabolism http://purl.obolibrary.org/obo/GO_0046372 GO:0046371 biolink:BiologicalProcess dTDP-mannose metabolic process The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate. go.json dTDP-mannose metabolism http://purl.obolibrary.org/obo/GO_0046371 GO:0046370 biolink:BiologicalProcess fructose biosynthetic process The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose. go.json fructose anabolism|fructose biosynthesis|fructose formation|fructose synthesis http://purl.obolibrary.org/obo/GO_0046370 GO:1900448 biolink:BiologicalProcess obsolete regulation of pyrimidine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_1900448 GO:1900447 biolink:BiologicalProcess regulation of cell morphogenesis involved in phenotypic switching Any process that modulates the frequency, rate or extent of cell morphogenesis contributing a phenotypic switch. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells, such as the opaque cells of C. albicans, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. go.json negative regulation of cell shape and cell size of phenotypic dimorphism|negative regulation of cell shape and cell size of phenotypic switching|positive regulation of cell shape and cell size of phenotypic dimorphism|positive regulation of cell shape and cell size of phenotypic switching|regulation of cell morphogenesis of phenotypic dimorphism|regulation of cell morphogenesis of phenotypic switching|regulation of cell shape and cell size of phenotypic dimorphism|regulation of cell shape and cell size of phenotypic switching http://purl.obolibrary.org/obo/GO_1900447 GO:1900449 biolink:BiologicalProcess regulation of glutamate receptor signaling pathway Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway. go.json regulation of glutamate signaling pathway|regulation of glutamate signalling pathway http://purl.obolibrary.org/obo/GO_1900449 GO:1900444 biolink:BiologicalProcess negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus. go.json down regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus|down-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus|downregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus|inhibition of filamentous growth of a population of unicellular organisms in response to biotic stimulus http://purl.obolibrary.org/obo/GO_1900444 GO:1900443 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus. go.json http://purl.obolibrary.org/obo/GO_1900443 GO:1900446 biolink:BiologicalProcess obsolete negative regulation of tRNA transcription from RNA polymerase III promoter OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of tRNA transcription from RNA polymerase III promoter. go.json down regulation of tRNA transcription from Pol III promoter|down regulation of tRNA transcription from RNA polymerase III promoter|down-regulation of tRNA transcription from Pol III promoter|down-regulation of tRNA transcription from RNA polymerase III promoter|downregulation of tRNA transcription from Pol III promoter|downregulation of tRNA transcription from RNA polymerase III promoter|inhibition of tRNA transcription from Pol III promoter|inhibition of tRNA transcription from RNA polymerase III promoter|negative regulation of tRNA transcription from Pol III promoter True http://purl.obolibrary.org/obo/GO_1900446 GO:1900445 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus. go.json activation of filamentous growth of a population of unicellular organisms in response to biotic stimulus|up regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus|up-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus|upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus http://purl.obolibrary.org/obo/GO_1900445 GO:0046379 biolink:BiologicalProcess extracellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides used in extracellular structures. go.json extracellular polysaccharide metabolism http://purl.obolibrary.org/obo/GO_0046379 GO:1900440 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms in response to neutral pH Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH. go.json http://purl.obolibrary.org/obo/GO_1900440 GO:0046378 biolink:BiologicalProcess enterobacterial common antigen metabolic process The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. go.json enterobacterial common antigen metabolism http://purl.obolibrary.org/obo/GO_0046378 GO:0046377 biolink:BiologicalProcess colanic acid metabolic process The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues. go.json colanic acid metabolism http://purl.obolibrary.org/obo/GO_0046377 GO:1900442 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH. go.json activation of filamentous growth of a population of unicellular organisms in response to neutral pH|up regulation of filamentous growth of a population of unicellular organisms in response to neutral pH|up-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH|upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH http://purl.obolibrary.org/obo/GO_1900442 GO:0046376 biolink:BiologicalProcess GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate. go.json GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism http://purl.obolibrary.org/obo/GO_0046376 GO:0061990 biolink:MolecularActivity beta-ketodecanoyl-[acyl-carrier-protein] synthase activity Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2. MetaCyc:RXN-13613|RHEA:42264 go.json http://purl.obolibrary.org/obo/GO_0061990 GO:1900441 biolink:BiologicalProcess negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH. go.json down regulation of filamentous growth of a population of unicellular organisms in response to neutral pH|down-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH|downregulation of filamentous growth of a population of unicellular organisms in response to neutral pH|inhibition of filamentous growth of a population of unicellular organisms in response to neutral pH http://purl.obolibrary.org/obo/GO_1900441 GO:0046375 biolink:BiologicalProcess K antigen metabolic process The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. go.json K antigen metabolism http://purl.obolibrary.org/obo/GO_0046375 GO:0061993 biolink:CellularComponent calcium:proton antiporter complex A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). go.json CAX1 homodimer|CAX1-CAX3 complex|CAX3 homodimer http://purl.obolibrary.org/obo/GO_0061993 GO:0061992 biolink:BiologicalProcess obsolete ATP-dependent chaperone mediated protein folding OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and dependent on ATP hydrolysis. go.json True http://purl.obolibrary.org/obo/GO_0061992 GO:0061995 biolink:MolecularActivity ATP-dependent protein-DNA complex displacement activity An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis. Reactome:R-HSA-9822115 go.json ATP-dependent protein-nucleic acid complex displacement activity http://purl.obolibrary.org/obo/GO_0061995 GO:0061994 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0061994 GO:0071319 biolink:BiologicalProcess cellular response to benzoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus. go.json http://purl.obolibrary.org/obo/GO_0071319 GO:0061999 biolink:BiologicalProcess regulation of cardiac endothelial to mesenchymal transition Any process that modulates the frequency, rate or extent of cardiac endothelial to mesenchymal transition. go.json http://purl.obolibrary.org/obo/GO_0061999 GO:0071318 biolink:BiologicalProcess cellular response to ATP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. go.json cellular response to adenosine 5'-triphosphate|cellular response to adenosine triphosphate http://purl.obolibrary.org/obo/GO_0071318 GO:0071317 biolink:BiologicalProcess cellular response to isoquinoline alkaloid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. go.json http://purl.obolibrary.org/obo/GO_0071317 GO:0071316 biolink:BiologicalProcess cellular response to nicotine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. go.json http://purl.obolibrary.org/obo/GO_0071316 GO:0071315 biolink:BiologicalProcess cellular response to morphine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. go.json http://purl.obolibrary.org/obo/GO_0071315 GO:0071314 biolink:BiologicalProcess cellular response to cocaine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. go.json http://purl.obolibrary.org/obo/GO_0071314 GO:0071313 biolink:BiologicalProcess cellular response to caffeine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. go.json http://purl.obolibrary.org/obo/GO_0071313 GO:0071312 biolink:BiologicalProcess cellular response to alkaloid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. go.json http://purl.obolibrary.org/obo/GO_0071312 GO:0071311 biolink:BiologicalProcess cellular response to acetate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. go.json http://purl.obolibrary.org/obo/GO_0071311 GO:0071310 biolink:BiologicalProcess cellular response to organic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. go.json http://purl.obolibrary.org/obo/GO_0071310 GO:0071341 biolink:CellularComponent medial cortical node A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis. go.json mid1p medial cortical dot|midsome http://purl.obolibrary.org/obo/GO_0071341 GO:0046385 biolink:BiologicalProcess deoxyribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. go.json deoxyribose phosphate anabolism|deoxyribose phosphate biosynthesis|deoxyribose phosphate formation|deoxyribose phosphate synthesis http://purl.obolibrary.org/obo/GO_0046385 GO:0046384 biolink:BiologicalProcess 2-deoxyribose 1-phosphate metabolic process The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. go.json 2-deoxyribose 1-phosphate metabolism|deoxyribose 1-phosphate metabolic process|deoxyribose 1-phosphate metabolism http://purl.obolibrary.org/obo/GO_0046384 GO:0071340 biolink:BiologicalProcess skeletal muscle acetylcholine-gated channel clustering The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals. go.json skeletal muscle AChR clustering|skeletal muscle nicotinic acetylcholine receptor clustering http://purl.obolibrary.org/obo/GO_0071340 GO:0046383 biolink:BiologicalProcess dTDP-rhamnose metabolic process The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. go.json dTDP-rhamnose metabolism http://purl.obolibrary.org/obo/GO_0046383 GO:0046382 biolink:BiologicalProcess GDP-D-rhamnose metabolic process The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate. go.json GDP-D-rhamnose metabolism http://purl.obolibrary.org/obo/GO_0046382 GO:1900459 biolink:BiologicalProcess positive regulation of brassinosteroid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway. go.json activation of brassinosteroid mediated signaling pathway|activation of brassinosteroid mediated signalling|positive regulation of brassinosteroid mediated signalling|up regulation of brassinosteroid mediated signaling pathway|up regulation of brassinosteroid mediated signalling|up-regulation of brassinosteroid mediated signaling pathway|up-regulation of brassinosteroid mediated signalling|upregulation of brassinosteroid mediated signaling pathway|upregulation of brassinosteroid mediated signalling http://purl.obolibrary.org/obo/GO_1900459 GO:0046381 biolink:BiologicalProcess CMP-N-acetylneuraminate metabolic process The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate. go.json CMP-N-acetylneuraminate metabolism http://purl.obolibrary.org/obo/GO_0046381 GO:1900458 biolink:BiologicalProcess negative regulation of brassinosteroid mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway. go.json down regulation of brassinosteroid mediated signaling pathway|down regulation of brassinosteroid mediated signalling|down-regulation of brassinosteroid mediated signaling pathway|down-regulation of brassinosteroid mediated signalling|downregulation of brassinosteroid mediated signaling pathway|downregulation of brassinosteroid mediated signalling|inhibition of brassinosteroid mediated signaling pathway|inhibition of brassinosteroid mediated signalling|negative regulation of brassinosteroid mediated signalling http://purl.obolibrary.org/obo/GO_1900458 GO:0046380 biolink:BiologicalProcess N-acetylneuraminate biosynthetic process The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. go.json N-acetylneuraminate anabolism|N-acetylneuraminate biosynthesis|N-acetylneuraminate formation|N-acetylneuraminate synthesis http://purl.obolibrary.org/obo/GO_0046380 GO:1900455 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900455 GO:1900454 biolink:BiologicalProcess positive regulation of long-term synaptic depression Any process that activates or increases the frequency, rate or extent of long term synaptic depression. go.json activation of LTD|activation of long term depression|activation of long term synaptic depression|positive regulation of LTD|positive regulation of long term depression|positive regulation of long term synaptic depression|up regulation of LTD|up regulation of long term depression|up regulation of long term synaptic depression|up-regulation of LTD|up-regulation of long term depression|up-regulation of long term synaptic depression|upregulation of LTD|upregulation of long term depression|upregulation of long term synaptic depression http://purl.obolibrary.org/obo/GO_1900454 GO:1900457 biolink:BiologicalProcess regulation of brassinosteroid mediated signaling pathway Any process that modulates the frequency, rate or extent of brassinosteroid mediated signaling pathway. go.json regulation of brassinosteroid mediated signalling http://purl.obolibrary.org/obo/GO_1900457 GO:1900456 biolink:BiologicalProcess obsolete regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json regulation of colony morphology by regulation of transcription from RNA polymerase II promoter|regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900456 GO:1900451 biolink:BiologicalProcess positive regulation of glutamate receptor signaling pathway Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway. go.json activation of glutamate receptor signaling pathway|activation of glutamate signaling pathway|activation of glutamate signalling pathway|positive regulation of glutamate signaling pathway|positive regulation of glutamate signalling pathway|up regulation of glutamate receptor signaling pathway|up regulation of glutamate signaling pathway|up regulation of glutamate signalling pathway|up-regulation of glutamate receptor signaling pathway|up-regulation of glutamate signaling pathway|up-regulation of glutamate signalling pathway|upregulation of glutamate receptor signaling pathway|upregulation of glutamate signaling pathway|upregulation of glutamate signalling pathway http://purl.obolibrary.org/obo/GO_1900451 GO:0046389 biolink:BiologicalProcess deoxyribose 5-phosphate metabolic process The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose. go.json deoxyribose 5-phosphate metabolism http://purl.obolibrary.org/obo/GO_0046389 GO:1900450 biolink:BiologicalProcess negative regulation of glutamate receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway. go.json down regulation of glutamate receptor signaling pathway|down regulation of glutamate signaling pathway|down regulation of glutamate signalling pathway|down-regulation of glutamate receptor signaling pathway|down-regulation of glutamate signaling pathway|down-regulation of glutamate signalling pathway|downregulation of glutamate receptor signaling pathway|downregulation of glutamate signaling pathway|downregulation of glutamate signalling pathway|inhibition of glutamate receptor signaling pathway|inhibition of glutamate signaling pathway|inhibition of glutamate signalling pathway|negative regulation of glutamate signaling pathway|negative regulation of glutamate signalling pathway http://purl.obolibrary.org/obo/GO_1900450 GO:0046388 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046388 GO:1900453 biolink:BiologicalProcess negative regulation of long-term synaptic depression Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression. go.json down regulation of LTD|down regulation of long term depression|down regulation of long term synaptic depression|down-regulation of LTD|down-regulation of long term depression|down-regulation of long term synaptic depression|downregulation of LTD|downregulation of long term depression|downregulation of long term synaptic depression|inhibition of LTD|inhibition of long term depression|inhibition of long term synaptic depression|negative regulation of LTD|negative regulation of long term depression|negative regulation of long term synaptic depression http://purl.obolibrary.org/obo/GO_1900453 GO:0046387 biolink:BiologicalProcess deoxyribose 1,5-bisphosphate metabolic process The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose. go.json deoxyribose 1,5-bisphosphate metabolism http://purl.obolibrary.org/obo/GO_0046387 GO:0046386 biolink:BiologicalProcess deoxyribose phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. go.json deoxyribose phosphate breakdown|deoxyribose phosphate catabolism|deoxyribose phosphate degradation http://purl.obolibrary.org/obo/GO_0046386 GO:1900452 biolink:BiologicalProcess regulation of long-term synaptic depression Any process that modulates the frequency, rate or extent of long term synaptic depression. go.json regulation of LTD|regulation of long term depression|regulation of long term synaptic depression http://purl.obolibrary.org/obo/GO_1900452 GO:1900460 biolink:BiologicalProcess obsolete negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of colony morphology by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900460 GO:0071349 biolink:BiologicalProcess cellular response to interleukin-12 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. go.json cellular response to IL-12 http://purl.obolibrary.org/obo/GO_0071349 GO:0071348 biolink:BiologicalProcess cellular response to interleukin-11 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus. go.json cellular response to IL-11 http://purl.obolibrary.org/obo/GO_0071348 GO:0071347 biolink:BiologicalProcess cellular response to interleukin-1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. go.json cellular response to IL-1 http://purl.obolibrary.org/obo/GO_0071347 GO:0071346 biolink:BiologicalProcess cellular response to type II interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. go.json cellular response to gamma-interferon|cellular response to immune interferon|cellular response to interferon-gamma|cellular response to type II IFN http://purl.obolibrary.org/obo/GO_0071346 GO:0071345 biolink:BiologicalProcess cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. go.json http://purl.obolibrary.org/obo/GO_0071345 GO:0071344 biolink:BiologicalProcess diphosphate metabolic process The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid. go.json pyrophosphate metabolism http://purl.obolibrary.org/obo/GO_0071344 GO:0071343 biolink:BiologicalProcess obsolete negative regulation of establishment of actomyosin contractile ring localization OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location. go.json negative regulation of establishment of actomyosin contractile ring localization|negative regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis|negative regulation of establishment of contractile ring localization involved in cell cycle cytokinesis|negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle True http://purl.obolibrary.org/obo/GO_0071343 GO:0071342 biolink:BiologicalProcess obsolete regulation of establishment of actomyosin contractile ring localization OBSOLETE. Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle. go.json True http://purl.obolibrary.org/obo/GO_0071342 GO:0046396 biolink:BiologicalProcess D-galacturonate metabolic process The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls. go.json D-galacturonate metabolism http://purl.obolibrary.org/obo/GO_0046396 GO:0071330 biolink:BiologicalProcess cellular response to trehalose-6-phosphate stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus. go.json http://purl.obolibrary.org/obo/GO_0071330 GO:0046395 biolink:BiologicalProcess carboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. go.json carboxylic acid breakdown|carboxylic acid catabolism|carboxylic acid degradation http://purl.obolibrary.org/obo/GO_0046395 GO:0046394 biolink:BiologicalProcess carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. go.json carboxylic acid anabolism|carboxylic acid biosynthesis|carboxylic acid formation|carboxylic acid synthesis http://purl.obolibrary.org/obo/GO_0046394 GO:0046393 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046393 GO:0046392 biolink:BiologicalProcess galactarate catabolic process The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid. MetaCyc:GALACTARDEG-PWY go.json D-galactarate breakdown|D-galactarate catabolic process|D-galactarate catabolism|D-galactarate degradation|galactarate breakdown|galactarate catabolism|galactarate degradation http://purl.obolibrary.org/obo/GO_0046392 GO:1900469 biolink:BiologicalProcess negative regulation of phosphatidylserine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process. go.json down regulation of phosphatidylserine anabolism|down regulation of phosphatidylserine biosynthesis|down regulation of phosphatidylserine biosynthetic process|down regulation of phosphatidylserine formation|down regulation of phosphatidylserine synthesis|down-regulation of phosphatidylserine anabolism|down-regulation of phosphatidylserine biosynthesis|down-regulation of phosphatidylserine biosynthetic process|down-regulation of phosphatidylserine formation|down-regulation of phosphatidylserine synthesis|downregulation of phosphatidylserine anabolism|downregulation of phosphatidylserine biosynthesis|downregulation of phosphatidylserine biosynthetic process|downregulation of phosphatidylserine formation|downregulation of phosphatidylserine synthesis|inhibition of phosphatidylserine anabolism|inhibition of phosphatidylserine biosynthesis|inhibition of phosphatidylserine biosynthetic process|inhibition of phosphatidylserine formation|inhibition of phosphatidylserine synthesis|negative regulation of phosphatidylserine anabolism|negative regulation of phosphatidylserine biosynthesis|negative regulation of phosphatidylserine formation|negative regulation of phosphatidylserine synthesis http://purl.obolibrary.org/obo/GO_1900469 GO:0046391 biolink:BiologicalProcess 5-phosphoribose 1-diphosphate metabolic process The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. MetaCyc:PRPP-PWY go.json 5-phosphoribose 1-diphosphate metabolism|PRPP metabolic process http://purl.obolibrary.org/obo/GO_0046391 GO:0046390 biolink:BiologicalProcess ribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar. go.json ribose phosphate anabolism|ribose phosphate biosynthesis|ribose phosphate formation|ribose phosphate synthesis http://purl.obolibrary.org/obo/GO_0046390 GO:1900466 biolink:BiologicalProcess obsolete positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json activation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter|activation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|activation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|activation of arginine formation by positive regulation of transcription from RNA polymerase II promoter|activation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter|positive regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter|up regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter|up regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter|up-regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter|up-regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter|upregulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter|upregulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900466 GO:1900465 biolink:BiologicalProcess obsolete negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular arginine catabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of arginine breakdown by negative regulation of transcription from RNA polymerase II promoter|negative regulation of arginine catabolism by negative regulation of transcription from RNA polymerase II promoter|negative regulation of arginine degradation by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900465 GO:1900468 biolink:BiologicalProcess regulation of phosphatidylserine biosynthetic process Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process. go.json regulation of phosphatidylserine anabolism|regulation of phosphatidylserine biosynthesis|regulation of phosphatidylserine formation|regulation of phosphatidylserine synthesis http://purl.obolibrary.org/obo/GO_1900468 GO:1900467 biolink:BiologicalProcess obsolete regulation of cellular potassium ion homeostasis OBSOLETE. Any process that modulates the frequency, rate or extent of cellular potassium ion homeostasis. go.json regulation of cellular potassium ion homeostasis True http://purl.obolibrary.org/obo/GO_1900467 GO:1900462 biolink:BiologicalProcess obsolete negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json True http://purl.obolibrary.org/obo/GO_1900462 GO:1900461 biolink:BiologicalProcess positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json http://purl.obolibrary.org/obo/GO_1900461 GO:0046399 biolink:BiologicalProcess glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid. go.json glucuronate anabolism|glucuronate biosynthesis|glucuronate formation|glucuronate synthesis http://purl.obolibrary.org/obo/GO_0046399 GO:0046398 biolink:BiologicalProcess UDP-glucuronate metabolic process The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. go.json UDP-glucuronate metabolism http://purl.obolibrary.org/obo/GO_0046398 GO:1900464 biolink:BiologicalProcess obsolete negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular hyperosmotic salinity response by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of cellular response to hyperosmotic salt stress by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900464 GO:0046397 biolink:BiologicalProcess galacturonate catabolic process The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid. go.json galacturonate breakdown|galacturonate catabolism|galacturonate degradation http://purl.obolibrary.org/obo/GO_0046397 GO:1900463 biolink:BiologicalProcess obsolete negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular response to alkalinity by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of cellular response to alkalinity by negative regulation of transcription from RNA polymerase II promoter|negative regulation of cellular response to basic pH by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900463 GO:1900471 biolink:BiologicalProcess obsolete negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of inositol biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of inositol anabolism by negative regulation of transcription from RNA polymerase II promoter|negative regulation of inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of inositol formation by negative regulation of transcription from RNA polymerase II promoter|negative regulation of inositol synthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of myo-inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of myo-inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter|negative regulation of vitamin Bh biosynthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of vitamin Bh biosynthetic process by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900471 GO:1900470 biolink:BiologicalProcess positive regulation of phosphatidylserine biosynthetic process Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process. go.json activation of phosphatidylserine anabolism|activation of phosphatidylserine biosynthesis|activation of phosphatidylserine biosynthetic process|activation of phosphatidylserine formation|activation of phosphatidylserine synthesis|positive regulation of phosphatidylserine anabolism|positive regulation of phosphatidylserine biosynthesis|positive regulation of phosphatidylserine formation|positive regulation of phosphatidylserine synthesis|up regulation of phosphatidylserine anabolism|up regulation of phosphatidylserine biosynthesis|up regulation of phosphatidylserine biosynthetic process|up regulation of phosphatidylserine formation|up regulation of phosphatidylserine synthesis|up-regulation of phosphatidylserine anabolism|up-regulation of phosphatidylserine biosynthesis|up-regulation of phosphatidylserine biosynthetic process|up-regulation of phosphatidylserine formation|up-regulation of phosphatidylserine synthesis|upregulation of phosphatidylserine anabolism|upregulation of phosphatidylserine biosynthesis|upregulation of phosphatidylserine biosynthetic process|upregulation of phosphatidylserine formation|upregulation of phosphatidylserine synthesis http://purl.obolibrary.org/obo/GO_1900470 GO:0071339 biolink:CellularComponent MLL1 complex A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. go.json http://purl.obolibrary.org/obo/GO_0071339 GO:0071338 biolink:BiologicalProcess positive regulation of hair follicle cell proliferation Any process that activates or increases the rate or extent of hair follicle cell proliferation. go.json activation of hair follicle cell proliferation|stimulation of hair follicle cell proliferation|up regulation of hair follicle cell proliferation|up-regulation of hair follicle cell proliferation|upregulation of hair follicle cell proliferation http://purl.obolibrary.org/obo/GO_0071338 GO:0071337 biolink:BiologicalProcess negative regulation of hair follicle cell proliferation Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation. go.json down regulation of hair follicle cell proliferation|down-regulation of hair follicle cell proliferation|downregulation of hair follicle cell proliferation|inhibition of hair follicle cell proliferation http://purl.obolibrary.org/obo/GO_0071337 GO:0071336 biolink:BiologicalProcess regulation of hair follicle cell proliferation Any process that modulates the frequency, rate or extent of hair follicle cell proliferation. go.json http://purl.obolibrary.org/obo/GO_0071336 GO:0071335 biolink:BiologicalProcess hair follicle cell proliferation The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population. go.json http://purl.obolibrary.org/obo/GO_0071335 GO:0071334 biolink:BiologicalProcess cellular response to rhamnose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus. go.json cellular response to L-rhamnose stimulus http://purl.obolibrary.org/obo/GO_0071334 GO:0071333 biolink:BiologicalProcess cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. go.json http://purl.obolibrary.org/obo/GO_0071333 GO:0071332 biolink:BiologicalProcess cellular response to fructose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. go.json http://purl.obolibrary.org/obo/GO_0071332 GO:0071331 biolink:BiologicalProcess cellular response to hexose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. go.json http://purl.obolibrary.org/obo/GO_0071331 GO:0046503 biolink:BiologicalProcess glycerolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. go.json glycerolipid breakdown|glycerolipid catabolism|glycerolipid degradation http://purl.obolibrary.org/obo/GO_0046503 GO:0046502 biolink:BiologicalProcess uroporphyrinogen III metabolic process The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds. go.json uroporphyrinogen III metabolism http://purl.obolibrary.org/obo/GO_0046502 GO:0046501 biolink:BiologicalProcess protoporphyrinogen IX metabolic process The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation. go.json protoporphyrinogen IX metabolism http://purl.obolibrary.org/obo/GO_0046501 GO:0046500 biolink:BiologicalProcess S-adenosylmethionine metabolic process The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. go.json S-adenosyl methionine metabolic process|S-adenosyl methionine metabolism|S-adenosylmethionine metabolism|SAM metabolic process http://purl.obolibrary.org/obo/GO_0046500 GO:0046509 biolink:MolecularActivity 1,2-diacylglycerol 3-beta-galactosyltransferase activity Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H+ + UDP. EC:2.4.1.46|KEGG_REACTION:R02691|MetaCyc:2.4.1.46-RXN|RHEA:14945 go.json 1-beta-MGDG activity|1beta-MGDG|MGDG synthase activity|UDP galactose-1,2-diacylglycerol galactosyltransferase activity|UDP-galactose-diacylglyceride galactosyltransferase activity|UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity|UDP-galactose:diacylglycerol galactosyltransferase activity|UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity|monogalactosyldiacylglycerol synthase activity|uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0046509 GO:0046508 biolink:MolecularActivity hydrolase activity, acting on carbon-sulfur bonds Catalysis of the hydrolysis of any carbon-sulfur bond, C-S. EC:3.13.-.- go.json hydrolase activity, acting on carbon-sulphur bonds http://purl.obolibrary.org/obo/GO_0046508 GO:0046507 biolink:MolecularActivity UDPsulfoquinovose synthase activity Catalysis of the reaction: sulfite + UDP-D-glucose = H2O + UDP-6-sulfoquinovose. EC:3.13.1.1|KEGG_REACTION:R05775|MetaCyc:RXN-1223|RHEA:13197 go.json UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity|UDP-sulfoquinovose synthase activity|UDPsulphoquinovose synthase activity|sulfite:UDP-glucose sulfotransferase activity http://purl.obolibrary.org/obo/GO_0046507 GO:0046506 biolink:BiologicalProcess sulfolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. go.json sulfolipid anabolism|sulfolipid biosynthesis|sulfolipid formation|sulfolipid synthesis|sulpholipid biosynthesis|sulpholipid biosynthetic process http://purl.obolibrary.org/obo/GO_0046506 GO:0046505 biolink:BiologicalProcess sulfolipid metabolic process The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. go.json sulfolipid metabolism|sulpholipid metabolic process|sulpholipid metabolism http://purl.obolibrary.org/obo/GO_0046505 GO:0046504 biolink:BiologicalProcess glycerol ether biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. go.json glycerol ether anabolism|glycerol ether biosynthesis|glycerol ether formation|glycerol ether synthesis http://purl.obolibrary.org/obo/GO_0046504 GO:0046514 biolink:BiologicalProcess ceramide catabolic process The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. go.json ceramide breakdown|ceramide catabolism|ceramide degradation http://purl.obolibrary.org/obo/GO_0046514 GO:0046513 biolink:BiologicalProcess ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. go.json ceramide anabolism|ceramide biosynthesis|ceramide formation|ceramide synthesis http://purl.obolibrary.org/obo/GO_0046513 GO:0046512 biolink:BiologicalProcess sphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. go.json sphingosine anabolism|sphingosine biosynthesis|sphingosine formation|sphingosine synthesis http://purl.obolibrary.org/obo/GO_0046512 GO:0046511 biolink:BiologicalProcess sphinganine biosynthetic process The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol. go.json dihydrosphingosine biosynthesis|dihydrosphingosine biosynthetic process|sphinganine anabolism|sphinganine biosynthesis|sphinganine formation|sphinganine synthesis http://purl.obolibrary.org/obo/GO_0046511 GO:0046510 biolink:MolecularActivity UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP. MetaCyc:RXN-1224|RHEA:49468 go.json UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity|sulfolipid synthase http://purl.obolibrary.org/obo/GO_0046510 GO:0046519 biolink:BiologicalProcess sphingoid metabolic process The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. go.json sphingoid base metabolic process|sphingoid base metabolism|sphingoid metabolism http://purl.obolibrary.org/obo/GO_0046519 GO:0046518 biolink:BiologicalProcess octamethylcyclotetrasiloxane metabolic process The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom. go.json octamethylcyclotetrasiloxane metabolism http://purl.obolibrary.org/obo/GO_0046518 GO:0046517 biolink:BiologicalProcess octamethylcyclotetrasiloxane catabolic process The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom. go.json octamethylcyclotetrasiloxane breakdown|octamethylcyclotetrasiloxane catabolism|octamethylcyclotetrasiloxane degradation http://purl.obolibrary.org/obo/GO_0046517 GO:0046516 biolink:BiologicalProcess hypusine metabolic process The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. go.json hypusine metabolism http://purl.obolibrary.org/obo/GO_0046516 GO:0046515 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046515 GO:0046525 biolink:MolecularActivity xylosylprotein 4-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. EC:2.4.1.133|MetaCyc:2.4.1.133-RXN|RHEA:15297|Reactome:R-HSA-1889981|Reactome:R-HSA-3560804 go.json UDP-D-galactose:D-xylose galactosyltransferase activity|UDP-D-galactose:xylose galactosyltransferase activity|UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity|UDP-galactose:xylose galactosyltransferase activity|UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity|galactosyltransferase I activity|uridine diphosphogalactose-xylose galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0046525 GO:0046524 biolink:MolecularActivity sucrose-phosphate synthase activity Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. EC:2.4.1.14|MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN|RHEA:22172 go.json SPS|UDP-glucose-fructose-phosphate glucosyltransferase activity|UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity|UDPglucose-fructose-phosphate glucosyltransferase activity|UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity|sucrose 6-phosphate synthase activity|sucrose phosphate synthetase activity|sucrose phosphate-uridine diphosphate glucosyltransferase activity|sucrosephosphate-UDP glucosyltransferase activity|uridine diphosphoglucose-fructose phosphate glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0046524 GO:0046523 biolink:MolecularActivity S-methyl-5-thioribose-1-phosphate isomerase activity Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. EC:5.3.1.23|KEGG_REACTION:R04420|MetaCyc:5.3.1.23-RXN|RHEA:19989|Reactome:R-HSA-1237096|Reactome:R-HSA-1299507 go.json 1-PMTR isomerase activity|1-phospho-5'-S-methylthioribose isomerase activity|5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity|5-methylthioribose-1-phosphate isomerase activity|MTR-1-P isomerase activity|S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity|S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity|S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity|S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity|methylthioribose 1-phosphate isomerase activity http://purl.obolibrary.org/obo/GO_0046523 GO:0046522 biolink:MolecularActivity S-methyl-5-thioribose kinase activity Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+. EC:2.7.1.100|KEGG_REACTION:R04143|MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN|RHEA:22312 go.json 5-methylthioribose kinase (phosphorylating)|5-methylthioribose kinase activity|ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity|ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity|MTR kinase activity|methylthioribose kinase activity http://purl.obolibrary.org/obo/GO_0046522 GO:0046521 biolink:BiologicalProcess sphingoid catabolic process The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. go.json sphingoid breakdown|sphingoid catabolism|sphingoid degradation http://purl.obolibrary.org/obo/GO_0046521 GO:0046520 biolink:BiologicalProcess sphingoid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. go.json sphingoid anabolism|sphingoid biosynthesis|sphingoid formation|sphingoid synthesis http://purl.obolibrary.org/obo/GO_0046520 GO:0046529 biolink:BiologicalProcess imaginal disc fusion, thorax closure The joining of the parts of the wing imaginal discs, giving rise to the adult thorax. go.json http://purl.obolibrary.org/obo/GO_0046529 GO:0046528 biolink:BiologicalProcess imaginal disc fusion The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis. go.json http://purl.obolibrary.org/obo/GO_0046528 GO:0046527 biolink:MolecularActivity glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. go.json http://purl.obolibrary.org/obo/GO_0046527 GO:0046526 biolink:MolecularActivity D-xylulose reductase activity Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH. EC:1.1.1.9|KEGG_REACTION:R01896|MetaCyc:D-XYLULOSE-REDUCTASE-RXN|RHEA:20433|Reactome:R-HSA-5662471 go.json xylitol dehydrogenase activity http://purl.obolibrary.org/obo/GO_0046526 GO:0046536 biolink:CellularComponent dosage compensation complex A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes. go.json http://purl.obolibrary.org/obo/GO_0046536 goslim_pir GO:0046535 biolink:BiologicalProcess detection of chemical stimulus involved in sensory perception of umami taste The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. go.json perception of umami taste, detection of chemical stimulus|perception of umami taste, sensory transduction of chemical stimulus|sensory detection of chemical stimulus during perception of umami taste|sensory detection of umami taste|sensory transduction of chemical stimulus during perception of umami taste|sensory transduction of umami taste|umami taste detection http://purl.obolibrary.org/obo/GO_0046535 GO:0046534 biolink:BiologicalProcess positive regulation of photoreceptor cell differentiation Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. go.json activation of photoreceptor cell differentiation|activation of photoreceptor differentiation|positive regulation of photoreceptor differentiation|stimulation of photoreceptor cell differentiation|stimulation of photoreceptor differentiation|up regulation of photoreceptor cell differentiation|up regulation of photoreceptor differentiation|up-regulation of photoreceptor cell differentiation|up-regulation of photoreceptor differentiation|upregulation of photoreceptor cell differentiation|upregulation of photoreceptor differentiation http://purl.obolibrary.org/obo/GO_0046534 GO:0046533 biolink:BiologicalProcess negative regulation of photoreceptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. go.json down regulation of photoreceptor cell differentiation|down regulation of photoreceptor differentiation|down-regulation of photoreceptor cell differentiation|down-regulation of photoreceptor differentiation|downregulation of photoreceptor cell differentiation|downregulation of photoreceptor differentiation|inhibition of photoreceptor cell differentiation|inhibition of photoreceptor differentiation|negative regulation of photoreceptor differentiation http://purl.obolibrary.org/obo/GO_0046533 GO:0046532 biolink:BiologicalProcess regulation of photoreceptor cell differentiation Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. go.json regulation of photoreceptor differentiation http://purl.obolibrary.org/obo/GO_0046532 GO:0046531 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046531 GO:0046530 biolink:BiologicalProcess photoreceptor cell differentiation The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0046530 GO:0046539 biolink:MolecularActivity histamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+. EC:2.1.1.8|KEGG_REACTION:R02155|MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN|RHEA:19301|Reactome:R-HSA-175993 go.json S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity|S-adenosylmethionine-histamine N-methyltransferase activity|histamine 1-methyltransferase activity|histamine methyltransferase activity|histamine-methylating enzyme|imidazolemethyltransferase activity http://purl.obolibrary.org/obo/GO_0046539 GO:0046538 biolink:MolecularActivity 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor. EC:5.4.2.11|KEGG_REACTION:R01516|MetaCyc:RXN-15513 go.json glycerate phosphomutase (diphosphoglycerate cofactor) activity http://purl.obolibrary.org/obo/GO_0046538 GO:0046537 biolink:MolecularActivity 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate. EC:5.4.2.12|MetaCyc:3PGAREARR-RXN go.json http://purl.obolibrary.org/obo/GO_0046537 GO:0046547 biolink:MolecularActivity trans-aconitate 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine. EC:2.1.1.145|KEGG_REACTION:R05764|MetaCyc:2.1.1.145-RXN|RHEA:22200 go.json S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0046547 GO:0046546 biolink:BiologicalProcess development of primary male sexual characteristics The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0046546 GO:0046545 biolink:BiologicalProcess development of primary female sexual characteristics The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0046545 GO:0046544 biolink:BiologicalProcess development of secondary male sexual characteristics The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0046544 GO:0046543 biolink:BiologicalProcess development of secondary female sexual characteristics The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion. go.json http://purl.obolibrary.org/obo/GO_0046543 GO:0046542 biolink:BiologicalProcess obsolete alpha-factor export OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell. go.json alpha-factor export True http://purl.obolibrary.org/obo/GO_0046542 GO:0046541 biolink:BiologicalProcess saliva secretion The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. Wikipedia:Salivation go.json salivation http://purl.obolibrary.org/obo/GO_0046541 GO:0046540 biolink:CellularComponent U4/U6 x U5 tri-snRNP complex A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. go.json U4/U6.U5 snRNP complex http://purl.obolibrary.org/obo/GO_0046540 GO:0071509 biolink:BiologicalProcess obsolete activation of MAPKK activity involved in conjugation with cellular fusion OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion. go.json activation of MAP kinase kinase activity during conjugation with cellular fusion|activation of MAPKK activity involved in mating response|conjugation with cellular fusion, activation of MAP kinase kinase activity|conjugation with cellular fusion, activation of MAPKK activity True http://purl.obolibrary.org/obo/GO_0071509 GO:0071508 biolink:BiologicalProcess obsolete activation of MAPK activity involved in conjugation with cellular fusion OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion. go.json activation of MAPK activity involved in mating response|conjugation with cellular fusion, activation of MAPK activity True http://purl.obolibrary.org/obo/GO_0071508 GO:0071507 biolink:BiologicalProcess pheromone response MAPK cascade A MAPK cascade that is part of a pheromone response ending in conjugation with cellular fusion. go.json Fus3 signaling cascade|MAPK cascade involved in conjugation with cellular fusion|MAPK signaling in response to pheromone|MAPKKK cascade involved in conjugation with cellular fusion|MAPKKK cascade involved in mating response|conjugation with cellular fusion, MAPKKK cascade|pheromone MAPK module http://purl.obolibrary.org/obo/GO_0071507 GO:0071506 biolink:BiologicalProcess cellular response to mycophenolic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus. go.json cellular response to mycophenolate http://purl.obolibrary.org/obo/GO_0071506 GO:0046549 biolink:BiologicalProcess retinal cone cell development Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. go.json http://purl.obolibrary.org/obo/GO_0046549 GO:0071505 biolink:BiologicalProcess response to mycophenolic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus. go.json response to mycophenolate http://purl.obolibrary.org/obo/GO_0071505 GO:0046548 biolink:BiologicalProcess retinal rod cell development Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. go.json http://purl.obolibrary.org/obo/GO_0046548 GO:0071504 biolink:BiologicalProcess cellular response to heparin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071504 GO:0071503 biolink:BiologicalProcess response to heparin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus. go.json http://purl.obolibrary.org/obo/GO_0071503 GO:0071502 biolink:BiologicalProcess cellular response to temperature stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. go.json cellular response to thermal stimulus http://purl.obolibrary.org/obo/GO_0071502 GO:0071501 biolink:BiologicalProcess cellular response to sterol depletion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. go.json cellular sterol depletion response http://purl.obolibrary.org/obo/GO_0071501 GO:0071500 biolink:BiologicalProcess cellular response to nitrosative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. go.json http://purl.obolibrary.org/obo/GO_0071500 GO:0046550 biolink:BiologicalProcess obsolete (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine OBSOLETE. The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7. go.json (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine|(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine|(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine True http://purl.obolibrary.org/obo/GO_0046550 GO:0046558 biolink:MolecularActivity arabinan endo-1,5-alpha-L-arabinosidase activity Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans. EC:3.2.1.99|MetaCyc:3.2.1.99-RXN go.json 1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity|endo-1,5-alpha-L-arabinanase activity|endo-alpha-1,5-arabanase activity|endo-arabanase activity http://purl.obolibrary.org/obo/GO_0046558 GO:0046557 biolink:MolecularActivity glucan endo-1,6-beta-glucosidase activity Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans. EC:3.2.1.75|MetaCyc:3.2.1.75-RXN go.json 1,6-beta-D-glucan glucanohydrolase activity|beta-1,6-glucan 6-glucanohydrolase activity|beta-1,6-glucan hydrolase activity|beta-1,6-glucanase activity|beta-1,6-glucanase-pustulanase activity|beta-1->6-glucan hydrolase activity|endo-(1,6)-beta-D-glucanase activity|endo-(1->6)-beta-D-glucanase activity|endo-1,6-beta-D-glucanase activity|endo-1,6-beta-glucanase activity|endo-beta-1,6-glucanase activity http://purl.obolibrary.org/obo/GO_0046557 GO:0046556 biolink:MolecularActivity alpha-L-arabinofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. EC:3.2.1.55|MetaCyc:3.2.1.55-RXN go.json L-arabinosidase activity|alpha-L-arabinanase activity|alpha-L-arabinofuranoside arabinofuranohydrolase activity|alpha-L-arabinofuranoside hydrolase activity|alpha-L-arabinosidase activity|alpha-N-arabinofuranosidase activity|alpha-arabinofuranosidase activity|alpha-arabinosidase activity|arabinofuranosidase activity|arabinosidase activity|polysaccharide alpha-L-arabinofuranosidase activity http://purl.obolibrary.org/obo/GO_0046556 GO:0046555 biolink:MolecularActivity acetylxylan esterase activity Catalysis of the deacetylation of xylans and xylo-oligosaccharides. EC:3.1.1.72|MetaCyc:3.1.1.72-RXN go.json http://purl.obolibrary.org/obo/GO_0046555 GO:0046554 biolink:MolecularActivity malate dehydrogenase (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. EC:1.1.1.82|KEGG_REACTION:R00343|MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN|RHEA:10824 go.json (S)-malate:NADP+ oxidoreductase activity|NADP malate dehydrogenase activity|NADP-linked malate dehydrogenase activity|NADP-malate dehydrogenase activity|malate NADP dehydrogenase activity|malic dehydrogenase (nicotinamide adenine dinucleotide phosphate) http://purl.obolibrary.org/obo/GO_0046554 GO:0046553 biolink:MolecularActivity D-malate dehydrogenase (decarboxylating) activity Catalysis of the reaction: (R)-malate + NAD+ = CO2 + NADH + pyruvate. EC:1.1.1.83|KEGG_REACTION:R00215|MetaCyc:1.1.1.83-RXN|RHEA:18365 go.json (R)-malate:NAD+ oxidoreductase (decarboxylating)|D-malate dehydrogenase activity|D-malic enzyme|bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating) http://purl.obolibrary.org/obo/GO_0046553 GO:0046552 biolink:BiologicalProcess photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. go.json http://purl.obolibrary.org/obo/GO_0046552 GO:0046551 biolink:BiologicalProcess retinal cone cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye. go.json http://purl.obolibrary.org/obo/GO_0046551 GO:0046559 biolink:MolecularActivity alpha-glucuronidase activity Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. EC:3.2.1.139|MetaCyc:3.2.1.139-RXN|RHEA:20005 go.json alpha-D-glucosiduronate glucuronohydrolase activity|alpha-glucosiduronase activity http://purl.obolibrary.org/obo/GO_0046559 GO:0071484 biolink:BiologicalProcess cellular response to light intensity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. go.json http://purl.obolibrary.org/obo/GO_0071484 GO:0071483 biolink:BiologicalProcess cellular response to blue light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. go.json cellular response to blue light stimulus http://purl.obolibrary.org/obo/GO_0071483 GO:0071482 biolink:BiologicalProcess cellular response to light stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. go.json http://purl.obolibrary.org/obo/GO_0071482 GO:0071481 biolink:BiologicalProcess cellular response to X-ray Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). go.json cellular response to X-ray radiation stimulus http://purl.obolibrary.org/obo/GO_0071481 GO:0071480 biolink:BiologicalProcess cellular response to gamma radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. go.json cellular response to gamma ray|cellular response to gamma-ray photon http://purl.obolibrary.org/obo/GO_0071480 GO:1900359 biolink:BiologicalProcess positive regulation of nigerotriose transport Any process that activates or increases the frequency, rate or extent of nigerotriose transport. go.json activation of nigerotriose transport|up regulation of nigerotriose transport|up-regulation of nigerotriose transport|upregulation of nigerotriose transport http://purl.obolibrary.org/obo/GO_1900359 GO:1900356 biolink:BiologicalProcess positive regulation of methanofuran metabolic process Any process that activates or increases the frequency, rate or extent of methanofuran metabolic process. go.json activation of methanofuran metabolic process|activation of methanofuran metabolism|positive regulation of methanofuran metabolism|up regulation of methanofuran metabolic process|up regulation of methanofuran metabolism|up-regulation of methanofuran metabolic process|up-regulation of methanofuran metabolism|upregulation of methanofuran metabolic process|upregulation of methanofuran metabolism http://purl.obolibrary.org/obo/GO_1900356 GO:1900355 biolink:BiologicalProcess negative regulation of methanofuran metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran metabolic process. go.json down regulation of methanofuran metabolic process|down regulation of methanofuran metabolism|down-regulation of methanofuran metabolic process|down-regulation of methanofuran metabolism|downregulation of methanofuran metabolic process|downregulation of methanofuran metabolism|inhibition of methanofuran metabolic process|inhibition of methanofuran metabolism|negative regulation of methanofuran metabolism http://purl.obolibrary.org/obo/GO_1900355 GO:1900358 biolink:BiologicalProcess negative regulation of nigerotriose transport Any process that stops, prevents or reduces the frequency, rate or extent of nigerotriose transport. go.json down regulation of nigerotriose transport|down-regulation of nigerotriose transport|downregulation of nigerotriose transport|inhibition of nigerotriose transport http://purl.obolibrary.org/obo/GO_1900358 GO:1900357 biolink:BiologicalProcess regulation of nigerotriose transport Any process that modulates the frequency, rate or extent of nigerotriose transport. go.json http://purl.obolibrary.org/obo/GO_1900357 GO:1900352 biolink:BiologicalProcess negative regulation of methanofuran biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process. go.json down regulation of methanofuran biosynthesis|down regulation of methanofuran biosynthetic process|down-regulation of methanofuran biosynthesis|down-regulation of methanofuran biosynthetic process|downregulation of methanofuran biosynthesis|downregulation of methanofuran biosynthetic process|inhibition of methanofuran biosynthesis|inhibition of methanofuran biosynthetic process|negative regulation of methanofuran biosynthesis http://purl.obolibrary.org/obo/GO_1900352 GO:1900351 biolink:BiologicalProcess regulation of methanofuran biosynthetic process Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process. go.json regulation of methanofuran biosynthesis http://purl.obolibrary.org/obo/GO_1900351 GO:1900354 biolink:BiologicalProcess regulation of methanofuran metabolic process Any process that modulates the frequency, rate or extent of methanofuran metabolic process. go.json regulation of methanofuran metabolism http://purl.obolibrary.org/obo/GO_1900354 GO:1900353 biolink:BiologicalProcess positive regulation of methanofuran biosynthetic process Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process. go.json activation of methanofuran biosynthesis|activation of methanofuran biosynthetic process|positive regulation of methanofuran biosynthesis|up regulation of methanofuran biosynthesis|up regulation of methanofuran biosynthetic process|up-regulation of methanofuran biosynthesis|up-regulation of methanofuran biosynthetic process|upregulation of methanofuran biosynthesis|upregulation of methanofuran biosynthetic process http://purl.obolibrary.org/obo/GO_1900353 GO:1900361 biolink:BiologicalProcess negative regulation of pentasaccharide transport Any process that stops, prevents or reduces the frequency, rate or extent of pentasaccharide transport. go.json down regulation of pentasaccharide transport|down-regulation of pentasaccharide transport|downregulation of pentasaccharide transport|inhibition of pentasaccharide transport http://purl.obolibrary.org/obo/GO_1900361 GO:1900360 biolink:BiologicalProcess regulation of pentasaccharide transport Any process that modulates the frequency, rate or extent of pentasaccharide transport. go.json http://purl.obolibrary.org/obo/GO_1900360 GO:0071489 biolink:BiologicalProcess cellular response to red or far red light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json http://purl.obolibrary.org/obo/GO_0071489 GO:0071488 biolink:BiologicalProcess cellular response to very low light intensity stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec. go.json http://purl.obolibrary.org/obo/GO_0071488 GO:0071487 biolink:BiologicalProcess cellular response to low light intensity stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2. go.json http://purl.obolibrary.org/obo/GO_0071487 GO:0071486 biolink:BiologicalProcess cellular response to high light intensity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. go.json http://purl.obolibrary.org/obo/GO_0071486 GO:0071485 biolink:BiologicalProcess cellular response to absence of light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. go.json cellular response to darkness http://purl.obolibrary.org/obo/GO_0071485 GO:0071473 biolink:BiologicalProcess cellular response to cation stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. go.json http://purl.obolibrary.org/obo/GO_0071473 GO:0071472 biolink:BiologicalProcess cellular response to salt stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json cellular response to ionic osmotic stress|cellular salinity response http://purl.obolibrary.org/obo/GO_0071472 GO:0071471 biolink:BiologicalProcess cellular response to non-ionic osmotic stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment. go.json http://purl.obolibrary.org/obo/GO_0071471 GO:0071470 biolink:BiologicalProcess cellular response to osmotic stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json cellular osmotic response|cellular osmotic stress response http://purl.obolibrary.org/obo/GO_0071470 GO:1900367 biolink:BiologicalProcess positive regulation of defense response to insect Any process that activates or increases the frequency, rate or extent of defense response to insect. go.json activation of defense response to insect|activation of physiological defense response to insect|positive regulation of physiological defense response to insect|up regulation of defense response to insect|up regulation of physiological defense response to insect|up-regulation of defense response to insect|up-regulation of physiological defense response to insect|upregulation of defense response to insect|upregulation of physiological defense response to insect http://purl.obolibrary.org/obo/GO_1900367 GO:1900366 biolink:BiologicalProcess negative regulation of defense response to insect Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. go.json down regulation of defense response to insect|down regulation of physiological defense response to insect|down-regulation of defense response to insect|down-regulation of physiological defense response to insect|downregulation of defense response to insect|downregulation of physiological defense response to insect|inhibition of defense response to insect|inhibition of physiological defense response to insect|negative regulation of physiological defense response to insect|susceptibility to insect http://purl.obolibrary.org/obo/GO_1900366 GO:1900369 biolink:BiologicalProcess negative regulation of post-transcriptional gene silencing by regulatory ncRNA Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA. go.json down regulation of RNA interference|down regulation of RNAi|down-regulation of RNA interference|down-regulation of RNAi|downregulation of RNA interference|downregulation of RNAi|inhibition of RNA interference|inhibition of RNAi|negative regulation of PTGS|negative regulation of RNA interference|negative regulation of RNAi|negative regulation of post-transcriptional gene silencing by RNA|negative regulation of post-transcriptional gene silencing by ncRNA|negative regulation of posttranscriptional gene silencing by siRNA http://purl.obolibrary.org/obo/GO_1900369 GO:1900368 biolink:BiologicalProcess regulation of post-transcriptional gene silencing by regulatory ncRNA Any process that modulates the frequency, rate or extent of post-transcriptional gene silencing by a non-coding RNA. go.json regulation of PTGS|regulation of RNA interference|regulation of RNAi|regulation of post-transcriptional gene silencing by RNA|regulation of post-transcriptional gene silencing by ncRNA http://purl.obolibrary.org/obo/GO_1900368 GO:1900363 biolink:BiologicalProcess obsolete regulation of mRNA polyadenylation OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA polyadenylation. go.json regulation of cleavage and polyadenylylation specificity factor activity|regulation of mRNA polyadenylylation True http://purl.obolibrary.org/obo/GO_1900363 GO:1900362 biolink:BiologicalProcess positive regulation of pentasaccharide transport Any process that activates or increases the frequency, rate or extent of pentasaccharide transport. go.json activation of pentasaccharide transport|up regulation of pentasaccharide transport|up-regulation of pentasaccharide transport|upregulation of pentasaccharide transport http://purl.obolibrary.org/obo/GO_1900362 GO:1900365 biolink:BiologicalProcess obsolete positive regulation of mRNA polyadenylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA polyadenylation. go.json activation of cleavage and polyadenylylation specificity factor activity|activation of mRNA polyadenylation|activation of mRNA polyadenylylation|positive regulation of cleavage and polyadenylylation specificity factor activity|positive regulation of mRNA polyadenylylation True http://purl.obolibrary.org/obo/GO_1900365 GO:1900364 biolink:BiologicalProcess negative regulation of mRNA polyadenylation Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation. go.json negative regulation of mRNA polyadenylylation http://purl.obolibrary.org/obo/GO_1900364 GO:1900370 biolink:BiologicalProcess positive regulation of post-transcriptional gene silencing by RNA Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA. go.json activation of RNA interference|activation of RNAi|positive regulation of PTGS|positive regulation of RNA interference|positive regulation of RNAi|up regulation of RNA interference|up regulation of RNAi|up-regulation of RNA interference|up-regulation of RNAi|upregulation of RNA interference|upregulation of RNAi http://purl.obolibrary.org/obo/GO_1900370 GO:1900372 biolink:BiologicalProcess negative regulation of purine nucleotide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes. go.json down regulation of purine nucleotide anabolism|down regulation of purine nucleotide biosynthesis|down regulation of purine nucleotide biosynthetic process|down regulation of purine nucleotide formation|down regulation of purine nucleotide synthesis|down-regulation of purine nucleotide anabolism|down-regulation of purine nucleotide biosynthesis|down-regulation of purine nucleotide biosynthetic process|down-regulation of purine nucleotide formation|down-regulation of purine nucleotide synthesis|downregulation of purine nucleotide anabolism|downregulation of purine nucleotide biosynthesis|downregulation of purine nucleotide biosynthetic process|downregulation of purine nucleotide formation|downregulation of purine nucleotide synthesis|inhibition of purine nucleotide anabolism|inhibition of purine nucleotide biosynthesis|inhibition of purine nucleotide biosynthetic process|inhibition of purine nucleotide formation|inhibition of purine nucleotide synthesis|negative regulation of purine nucleotide anabolism|negative regulation of purine nucleotide biosynthesis|negative regulation of purine nucleotide formation|negative regulation of purine nucleotide synthesis http://purl.obolibrary.org/obo/GO_1900372 GO:1900371 biolink:BiologicalProcess regulation of purine nucleotide biosynthetic process Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes. go.json regulation of purine nucleotide anabolism|regulation of purine nucleotide biosynthesis|regulation of purine nucleotide formation|regulation of purine nucleotide synthesis http://purl.obolibrary.org/obo/GO_1900371 GO:0071479 biolink:BiologicalProcess cellular response to ionizing radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. go.json cellular response to ionising radiation|cellular response to ionizing radiation stimulus http://purl.obolibrary.org/obo/GO_0071479 GO:0071478 biolink:BiologicalProcess cellular response to radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. go.json cellular response to electromagnetic radiation stimulus|cellular response to radiation stimulus http://purl.obolibrary.org/obo/GO_0071478 GO:0071477 biolink:BiologicalProcess cellular hypotonic salinity response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json cellular response to hypotonic salt stress http://purl.obolibrary.org/obo/GO_0071477 GO:0071476 biolink:BiologicalProcess cellular hypotonic response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. go.json cellular hypo-osmotic response http://purl.obolibrary.org/obo/GO_0071476 GO:0071475 biolink:BiologicalProcess cellular hyperosmotic salinity response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. go.json cellular response to hyperosmotic salt stress http://purl.obolibrary.org/obo/GO_0071475 GO:0071474 biolink:BiologicalProcess cellular hyperosmotic response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. go.json cellular HOG response|cellular hypertonic response|cellular response to hypertonicity http://purl.obolibrary.org/obo/GO_0071474 GO:1900378 biolink:BiologicalProcess positive regulation of secondary metabolite biosynthetic process Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. go.json activation of secondary metabolite biosynthesis|activation of secondary metabolite biosynthetic process|positive regulation of secondary metabolite biosynthesis|up regulation of secondary metabolite biosynthesis|up regulation of secondary metabolite biosynthetic process|up-regulation of secondary metabolite biosynthesis|up-regulation of secondary metabolite biosynthetic process|upregulation of secondary metabolite biosynthesis|upregulation of secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_1900378 GO:1900377 biolink:BiologicalProcess negative regulation of secondary metabolite biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. go.json down regulation of secondary metabolite biosynthesis|down regulation of secondary metabolite biosynthetic process|down-regulation of secondary metabolite biosynthesis|down-regulation of secondary metabolite biosynthetic process|downregulation of secondary metabolite biosynthesis|downregulation of secondary metabolite biosynthetic process|inhibition of secondary metabolite biosynthesis|inhibition of secondary metabolite biosynthetic process|negative regulation of secondary metabolite biosynthesis http://purl.obolibrary.org/obo/GO_1900377 GO:1900379 biolink:BiologicalProcess regulation of asperthecin biosynthetic process Any process that modulates the frequency, rate or extent of asperthecin biosynthetic process. go.json regulation of asperthecin biosynthesis|regulation of asperthecin formation|regulation of asperthecin synthesis http://purl.obolibrary.org/obo/GO_1900379 GO:1900374 biolink:BiologicalProcess obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching. go.json activation of mating type switching by regulation of transcription from RNA polymerase II promoter|stimulation of mating type switching by regulation of transcription from RNA polymerase II promoter|up regulation of mating type switching by regulation of transcription from RNA polymerase II promoter|up-regulation of mating type switching by regulation of transcription from RNA polymerase II promoter|upregulation of mating type switching by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900374 GO:1900373 biolink:BiologicalProcess positive regulation of purine nucleotide biosynthetic process Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes. go.json activation of purine nucleotide anabolism|activation of purine nucleotide biosynthesis|activation of purine nucleotide biosynthetic process|activation of purine nucleotide formation|activation of purine nucleotide synthesis|positive regulation of purine nucleotide anabolism|positive regulation of purine nucleotide biosynthesis|positive regulation of purine nucleotide formation|positive regulation of purine nucleotide synthesis|up regulation of purine nucleotide anabolism|up regulation of purine nucleotide biosynthesis|up regulation of purine nucleotide biosynthetic process|up regulation of purine nucleotide formation|up regulation of purine nucleotide synthesis|up-regulation of purine nucleotide anabolism|up-regulation of purine nucleotide biosynthesis|up-regulation of purine nucleotide biosynthetic process|up-regulation of purine nucleotide formation|up-regulation of purine nucleotide synthesis|upregulation of purine nucleotide anabolism|upregulation of purine nucleotide biosynthesis|upregulation of purine nucleotide biosynthetic process|upregulation of purine nucleotide formation|upregulation of purine nucleotide synthesis http://purl.obolibrary.org/obo/GO_1900373 GO:1900376 biolink:BiologicalProcess regulation of secondary metabolite biosynthetic process Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. go.json regulation of secondary metabolite biosynthesis http://purl.obolibrary.org/obo/GO_1900376 GO:1900375 biolink:BiologicalProcess obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process. go.json activation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter|activation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|activation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|activation of inositol formation by positive regulation of transcription from RNA polymerase II promoter|activation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter|activation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|activation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|activation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter|activation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter|positive regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter|up regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter|up regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter|up-regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter|up-regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter|upregulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter|upregulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900375 GO:1900381 biolink:BiologicalProcess positive regulation of asperthecin biosynthetic process Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process. go.json activation of asperthecin biosynthesis|activation of asperthecin biosynthetic process|activation of asperthecin formation|activation of asperthecin synthesis|positive regulation of asperthecin biosynthesis|positive regulation of asperthecin formation|positive regulation of asperthecin synthesis|up regulation of asperthecin biosynthesis|up regulation of asperthecin biosynthetic process|up regulation of asperthecin formation|up regulation of asperthecin synthesis|up-regulation of asperthecin biosynthesis|up-regulation of asperthecin biosynthetic process|up-regulation of asperthecin formation|up-regulation of asperthecin synthesis|upregulation of asperthecin biosynthesis|upregulation of asperthecin biosynthetic process|upregulation of asperthecin formation|upregulation of asperthecin synthesis http://purl.obolibrary.org/obo/GO_1900381 GO:1900380 biolink:BiologicalProcess negative regulation of asperthecin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process. go.json down regulation of asperthecin biosynthesis|down regulation of asperthecin biosynthetic process|down regulation of asperthecin formation|down regulation of asperthecin synthesis|down-regulation of asperthecin biosynthesis|down-regulation of asperthecin biosynthetic process|down-regulation of asperthecin formation|down-regulation of asperthecin synthesis|downregulation of asperthecin biosynthesis|downregulation of asperthecin biosynthetic process|downregulation of asperthecin formation|downregulation of asperthecin synthesis|inhibition of asperthecin biosynthesis|inhibition of asperthecin biosynthetic process|inhibition of asperthecin formation|inhibition of asperthecin synthesis|negative regulation of asperthecin biosynthesis|negative regulation of asperthecin formation|negative regulation of asperthecin synthesis http://purl.obolibrary.org/obo/GO_1900380 GO:1900383 biolink:BiologicalProcess regulation of synaptic plasticity by receptor localization to synapse Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse. go.json regulation of synaptic plasticity by receptor localisation to synapse http://purl.obolibrary.org/obo/GO_1900383 GO:1900382 biolink:BiologicalProcess obsolete regulation of thiamine biosynthetic process by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of thiamine biosynthetic process. go.json regulation of thiamin biosynthetic process by regulation of transcription from RNA polymerase II promoter|regulation of thiamine anabolism by regulation of transcription from RNA polymerase II promoter|regulation of thiamine biosynthesis by regulation of transcription from RNA polymerase II promoter|regulation of thiamine formation by regulation of transcription from RNA polymerase II promoter|regulation of thiamine synthesis by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900382 GO:0071495 biolink:BiologicalProcess cellular response to endogenous stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. go.json http://purl.obolibrary.org/obo/GO_0071495 gocheck_do_not_manually_annotate GO:0071494 biolink:BiologicalProcess cellular response to UV-C Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. go.json cellular response to UV-C light stimulus|cellular response to UV-C radiation stimulus|cellular response to UVC light stimulus|cellular response to UVC radiation stimulus|cellular response to germicidal ultraviolet light stimulus|cellular response to germicidal ultraviolet radiation stimulus|cellular response to shortwave ultraviolet light stimulus|cellular response to shortwave ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_0071494 GO:0071493 biolink:BiologicalProcess cellular response to UV-B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. go.json cellular response to UV-B light stimulus|cellular response to UV-B radiation stimulus|cellular response to UVB light stimulus|cellular response to UVB radiation stimulus|cellular response to medium wave ultraviolet light stimulus|cellular response to medium wave ultraviolet radiation stimulus http://purl.obolibrary.org/obo/GO_0071493 GO:0071492 biolink:BiologicalProcess cellular response to UV-A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. go.json cellular response to UV-A light stimulus|cellular response to UV-A radiation stimulus|cellular response to UVA light stimulus|cellular response to UVA radiation stimulus http://purl.obolibrary.org/obo/GO_0071492 GO:0071491 biolink:BiologicalProcess cellular response to red light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json cellular response to red light stimulus http://purl.obolibrary.org/obo/GO_0071491 GO:0071490 biolink:BiologicalProcess cellular response to far red light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. go.json cellular response to far red light stimulus http://purl.obolibrary.org/obo/GO_0071490 GO:1900389 biolink:BiologicalProcess obsolete regulation of glucose import by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of glucose import. go.json regulation of glucose uptake by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900389 GO:1900388 biolink:BiologicalProcess obsolete regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of vesicle-mediated transport. go.json regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900388 GO:1900385 biolink:BiologicalProcess negative regulation of flavonol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of flavonol biosynthetic process. go.json down regulation of flavonol biosynthetic process|down-regulation of flavonol biosynthetic process|downregulation of flavonol biosynthetic process|inhibition of flavonol biosynthetic process http://purl.obolibrary.org/obo/GO_1900385 GO:1900384 biolink:BiologicalProcess regulation of flavonol biosynthetic process Any process that modulates the frequency, rate or extent of flavonol biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_1900384 GO:1900387 biolink:BiologicalProcess obsolete negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cell-cell adhesion. go.json True http://purl.obolibrary.org/obo/GO_1900387 GO:1900386 biolink:BiologicalProcess positive regulation of flavonol biosynthetic process Any process that activates or increases the frequency, rate or extent of flavonol biosynthetic process. go.json activation of flavonol biosynthetic process|up regulation of flavonol biosynthetic process|up-regulation of flavonol biosynthetic process|upregulation of flavonol biosynthetic process http://purl.obolibrary.org/obo/GO_1900386 GO:1900392 biolink:BiologicalProcess obsolete regulation of transport by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of transport. go.json True http://purl.obolibrary.org/obo/GO_1900392 GO:1900391 biolink:BiologicalProcess obsolete regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cAMP-mediated signaling. go.json regulation of cAMP-mediated signalling by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900391 GO:1900394 biolink:BiologicalProcess regulation of kojic acid biosynthetic process Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process. go.json regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|regulation of C6H6O4 anabolism|regulation of C6H6O4 biosynthesis|regulation of C6H6O4 biosynthetic process|regulation of C6H6O4 formation|regulation of C6H6O4 synthesis|regulation of kojic acid anabolism|regulation of kojic acid biosynthesis|regulation of kojic acid formation|regulation of kojic acid synthesis http://purl.obolibrary.org/obo/GO_1900394 GO:1900393 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900393 GO:1900390 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900390 GO:0071499 biolink:BiologicalProcess cellular response to laminar fluid shear stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. go.json http://purl.obolibrary.org/obo/GO_0071499 GO:0071498 biolink:BiologicalProcess cellular response to fluid shear stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. go.json http://purl.obolibrary.org/obo/GO_0071498 GO:0071497 biolink:BiologicalProcess cellular response to freezing Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. go.json antifreeze activity|ice nucleation inhibitor activity http://purl.obolibrary.org/obo/GO_0071497 GO:0071496 biolink:BiologicalProcess cellular response to external stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0071496 gocheck_do_not_manually_annotate GO:1900399 biolink:BiologicalProcess positive regulation of pyrimidine nucleotide biosynthetic process Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process. go.json activation of pyrimidine nucleotide anabolism|activation of pyrimidine nucleotide biosynthesis|activation of pyrimidine nucleotide biosynthetic process|activation of pyrimidine nucleotide formation|activation of pyrimidine nucleotide synthesis|positive regulation of pyrimidine nucleotide anabolism|positive regulation of pyrimidine nucleotide biosynthesis|positive regulation of pyrimidine nucleotide formation|positive regulation of pyrimidine nucleotide synthesis|up regulation of pyrimidine nucleotide anabolism|up regulation of pyrimidine nucleotide biosynthesis|up regulation of pyrimidine nucleotide biosynthetic process|up regulation of pyrimidine nucleotide formation|up regulation of pyrimidine nucleotide synthesis|up-regulation of pyrimidine nucleotide anabolism|up-regulation of pyrimidine nucleotide biosynthesis|up-regulation of pyrimidine nucleotide biosynthetic process|up-regulation of pyrimidine nucleotide formation|up-regulation of pyrimidine nucleotide synthesis|upregulation of pyrimidine nucleotide anabolism|upregulation of pyrimidine nucleotide biosynthesis|upregulation of pyrimidine nucleotide biosynthetic process|upregulation of pyrimidine nucleotide formation|upregulation of pyrimidine nucleotide synthesis http://purl.obolibrary.org/obo/GO_1900399 GO:1900396 biolink:BiologicalProcess positive regulation of kojic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of kojic acid biosynthetic process. go.json activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|activation of C6H6O4 anabolism|activation of C6H6O4 biosynthesis|activation of C6H6O4 biosynthetic process|activation of C6H6O4 formation|activation of C6H6O4 synthesis|activation of kojic acid anabolism|activation of kojic acid biosynthesis|activation of kojic acid biosynthetic process|activation of kojic acid formation|activation of kojic acid synthesis|positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|positive regulation of C6H6O4 anabolism|positive regulation of C6H6O4 biosynthesis|positive regulation of C6H6O4 biosynthetic process|positive regulation of C6H6O4 formation|positive regulation of C6H6O4 synthesis|positive regulation of kojic acid anabolism|positive regulation of kojic acid biosynthesis|positive regulation of kojic acid formation|positive regulation of kojic acid synthesis|up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|up regulation of C6H6O4 anabolism|up regulation of C6H6O4 biosynthesis|up regulation of C6H6O4 biosynthetic process|up regulation of C6H6O4 formation|up regulation of C6H6O4 synthesis|up regulation of kojic acid anabolism|up regulation of kojic acid biosynthesis|up regulation of kojic acid biosynthetic process|up regulation of kojic acid formation|up regulation of kojic acid synthesis|up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|up-regulation of C6H6O4 anabolism|up-regulation of C6H6O4 biosynthesis|up-regulation of C6H6O4 biosynthetic process|up-regulation of C6H6O4 formation|up-regulation of C6H6O4 synthesis|up-regulation of kojic acid anabolism|up-regulation of kojic acid biosynthesis|up-regulation of kojic acid biosynthetic process|up-regulation of kojic acid formation|up-regulation of kojic acid synthesis|upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|upregulation of C6H6O4 anabolism|upregulation of C6H6O4 biosynthesis|upregulation of C6H6O4 biosynthetic process|upregulation of C6H6O4 formation|upregulation of C6H6O4 synthesis|upregulation of kojic acid anabolism|upregulation of kojic acid biosynthesis|upregulation of kojic acid biosynthetic process|upregulation of kojic acid formation|upregulation of kojic acid synthesis http://purl.obolibrary.org/obo/GO_1900396 GO:1900395 biolink:BiologicalProcess negative regulation of kojic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process. go.json down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|down regulation of C6H6O4 anabolism|down regulation of C6H6O4 biosynthesis|down regulation of C6H6O4 biosynthetic process|down regulation of C6H6O4 formation|down regulation of C6H6O4 synthesis|down regulation of kojic acid anabolism|down regulation of kojic acid biosynthesis|down regulation of kojic acid biosynthetic process|down regulation of kojic acid formation|down regulation of kojic acid synthesis|down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|down-regulation of C6H6O4 anabolism|down-regulation of C6H6O4 biosynthesis|down-regulation of C6H6O4 biosynthetic process|down-regulation of C6H6O4 formation|down-regulation of C6H6O4 synthesis|down-regulation of kojic acid anabolism|down-regulation of kojic acid biosynthesis|down-regulation of kojic acid biosynthetic process|down-regulation of kojic acid formation|down-regulation of kojic acid synthesis|downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|downregulation of C6H6O4 anabolism|downregulation of C6H6O4 biosynthesis|downregulation of C6H6O4 biosynthetic process|downregulation of C6H6O4 formation|downregulation of C6H6O4 synthesis|downregulation of kojic acid anabolism|downregulation of kojic acid biosynthesis|downregulation of kojic acid biosynthetic process|downregulation of kojic acid formation|downregulation of kojic acid synthesis|inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|inhibition of C6H6O4 anabolism|inhibition of C6H6O4 biosynthesis|inhibition of C6H6O4 biosynthetic process|inhibition of C6H6O4 formation|inhibition of C6H6O4 synthesis|inhibition of kojic acid anabolism|inhibition of kojic acid biosynthesis|inhibition of kojic acid biosynthetic process|inhibition of kojic acid formation|inhibition of kojic acid synthesis|negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism|negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis|negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process|negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation|negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis|negative regulation of C6H6O4 anabolism|negative regulation of C6H6O4 biosynthesis|negative regulation of C6H6O4 biosynthetic process|negative regulation of C6H6O4 formation|negative regulation of C6H6O4 synthesis|negative regulation of kojic acid anabolism|negative regulation of kojic acid biosynthesis|negative regulation of kojic acid formation|negative regulation of kojic acid synthesis http://purl.obolibrary.org/obo/GO_1900395 GO:1900398 biolink:BiologicalProcess negative regulation of pyrimidine nucleotide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process. go.json down regulation of pyrimidine nucleotide anabolism|down regulation of pyrimidine nucleotide biosynthesis|down regulation of pyrimidine nucleotide biosynthetic process|down regulation of pyrimidine nucleotide formation|down regulation of pyrimidine nucleotide synthesis|down-regulation of pyrimidine nucleotide anabolism|down-regulation of pyrimidine nucleotide biosynthesis|down-regulation of pyrimidine nucleotide biosynthetic process|down-regulation of pyrimidine nucleotide formation|down-regulation of pyrimidine nucleotide synthesis|downregulation of pyrimidine nucleotide anabolism|downregulation of pyrimidine nucleotide biosynthesis|downregulation of pyrimidine nucleotide biosynthetic process|downregulation of pyrimidine nucleotide formation|downregulation of pyrimidine nucleotide synthesis|inhibition of pyrimidine nucleotide anabolism|inhibition of pyrimidine nucleotide biosynthesis|inhibition of pyrimidine nucleotide biosynthetic process|inhibition of pyrimidine nucleotide formation|inhibition of pyrimidine nucleotide synthesis|negative regulation of pyrimidine nucleotide anabolism|negative regulation of pyrimidine nucleotide biosynthesis|negative regulation of pyrimidine nucleotide formation|negative regulation of pyrimidine nucleotide synthesis http://purl.obolibrary.org/obo/GO_1900398 GO:1900397 biolink:BiologicalProcess regulation of pyrimidine nucleotide biosynthetic process Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process. go.json regulation of pyrimidine nucleotide anabolism|regulation of pyrimidine nucleotide biosynthesis|regulation of pyrimidine nucleotide formation|regulation of pyrimidine nucleotide synthesis http://purl.obolibrary.org/obo/GO_1900397 OIO:SynonymTypeProperty biolink:OntologyClass synonym_type_property go.json http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty GO:0046440 biolink:BiologicalProcess L-lysine metabolic process The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid. go.json L-lysine metabolism http://purl.obolibrary.org/obo/GO_0046440 GO:0046448 biolink:BiologicalProcess tropane alkaloid metabolic process The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. go.json tropane alkaloid metabolism http://purl.obolibrary.org/obo/GO_0046448 GO:0046447 biolink:BiologicalProcess terpenoid indole alkaloid metabolic process The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate). go.json terpenoid indole alkaloid metabolism http://purl.obolibrary.org/obo/GO_0046447 GO:0046446 biolink:BiologicalProcess purine alkaloid metabolic process The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure. go.json purine alkaloid metabolism http://purl.obolibrary.org/obo/GO_0046446 GO:0046445 biolink:BiologicalProcess benzyl isoquinoline alkaloid metabolic process The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. go.json benzyl isoquinoline alkaloid metabolism http://purl.obolibrary.org/obo/GO_0046445 GO:0046444 biolink:BiologicalProcess FMN metabolic process The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. go.json FMN metabolism http://purl.obolibrary.org/obo/GO_0046444 GO:0046443 biolink:BiologicalProcess FAD metabolic process The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide. go.json FAD metabolism|oxidized flavin adenine dinucleotide metabolic process|oxidized flavin adenine dinucleotide metabolism|oxidized flavin-adenine dinucleotide metabolic process|oxidized flavin-adenine dinucleotide metabolism http://purl.obolibrary.org/obo/GO_0046443 GO:0046442 biolink:BiologicalProcess aerobactin metabolic process The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. go.json aerobactin metabolism http://purl.obolibrary.org/obo/GO_0046442 GO:0046441 biolink:BiologicalProcess D-lysine metabolic process The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid. go.json D-lysine metabolism http://purl.obolibrary.org/obo/GO_0046441 GO:0071409 biolink:BiologicalProcess cellular response to cycloheximide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. go.json cellular response to actidione http://purl.obolibrary.org/obo/GO_0071409 GO:0071408 biolink:BiologicalProcess cellular response to cycloalkane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n. go.json http://purl.obolibrary.org/obo/GO_0071408 GO:0071407 biolink:BiologicalProcess cellular response to organic cyclic compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. go.json cellular response to organic cyclic substance http://purl.obolibrary.org/obo/GO_0071407 GO:0071406 biolink:BiologicalProcess cellular response to methylmercury Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. go.json cellular response to CH3-Hg+|cellular response to MeHg+ http://purl.obolibrary.org/obo/GO_0071406 GO:0071405 biolink:BiologicalProcess cellular response to methanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus. go.json http://purl.obolibrary.org/obo/GO_0071405 GO:0046449 biolink:BiologicalProcess creatinine metabolic process The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. go.json creatinine metabolism http://purl.obolibrary.org/obo/GO_0046449 GO:0071404 biolink:BiologicalProcess cellular response to low-density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. go.json response to low density lipoprotein particle|response to low-density lipoprotein particle|response to low-density lipoprotein particle stimulus http://purl.obolibrary.org/obo/GO_0071404 GO:0071403 biolink:BiologicalProcess cellular response to high density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus. go.json cellular response to high-density lipoprotein particle stimulus|response to high density lipoprotein particle|response to high density lipoprotein particle stimulus http://purl.obolibrary.org/obo/GO_0071403 GO:0071402 biolink:BiologicalProcess cellular response to lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. go.json http://purl.obolibrary.org/obo/GO_0071402 GO:0071401 biolink:BiologicalProcess cellular response to triglyceride Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus. go.json cellular response to triacylglyceride|cellular response to triacylglycerol http://purl.obolibrary.org/obo/GO_0071401 GO:0071400 biolink:BiologicalProcess cellular response to oleic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus. go.json cellular response to oleate http://purl.obolibrary.org/obo/GO_0071400 GO:0046451 biolink:BiologicalProcess diaminopimelate metabolic process The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. go.json diaminopimelate metabolism http://purl.obolibrary.org/obo/GO_0046451 GO:0046450 biolink:BiologicalProcess dethiobiotin metabolic process The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms. go.json desthiobiotin metabolic process|desthiobiotin metabolism|dethiobiotin metabolism http://purl.obolibrary.org/obo/GO_0046450 GO:0046459 biolink:BiologicalProcess short-chain fatty acid metabolic process The chemical reactions and pathways involving a fatty acid with an aliphatic tail of less than 6 carbons. go.json short-chain fatty acid metabolism http://purl.obolibrary.org/obo/GO_0046459 GO:0046458 biolink:BiologicalProcess hexadecanal metabolic process The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde. go.json hexadecanal metabolism http://purl.obolibrary.org/obo/GO_0046458 GO:0046457 biolink:BiologicalProcess prostanoid biosynthetic process The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. Wikipedia:Prostanoid#Biosynthesis go.json prostanoid anabolism|prostanoid biosynthesis|prostanoid formation|prostanoid synthesis http://purl.obolibrary.org/obo/GO_0046457 GO:0046456 biolink:BiologicalProcess icosanoid biosynthetic process The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. Wikipedia:Eicosanoid go.json eicosanoid biosynthesis|eicosanoid biosynthetic process|eoxin biosynthesis|eoxin synthesis|icosanoid anabolism|icosanoid biosynthesis|icosanoid formation|icosanoid synthesis http://purl.obolibrary.org/obo/GO_0046456 GO:0046455 biolink:BiologicalProcess organosilicon catabolic process The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon. go.json organosilicon breakdown|organosilicon catabolism|organosilicon degradation|organosilicone catabolic process|organosilicone catabolism http://purl.obolibrary.org/obo/GO_0046455 GO:0046454 biolink:BiologicalProcess dimethylsilanediol metabolic process The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. go.json dimethylsilanediol metabolism http://purl.obolibrary.org/obo/GO_0046454 GO:0046453 biolink:BiologicalProcess dipyrrin metabolic process The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. go.json dipyrrin metabolism http://purl.obolibrary.org/obo/GO_0046453 GO:0046452 biolink:BiologicalProcess dihydrofolate metabolic process The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate. go.json dihydrofolate metabolism|dihydrofolate reduction http://purl.obolibrary.org/obo/GO_0046452 GO:0046462 biolink:BiologicalProcess monoacylglycerol metabolic process The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. go.json monoacylglycerol metabolism|monoglyceride metabolic process|monoglyceride metabolism http://purl.obolibrary.org/obo/GO_0046462 GO:0046461 biolink:BiologicalProcess neutral lipid catabolic process The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. go.json neutral lipid breakdown|neutral lipid catabolism|neutral lipid degradation http://purl.obolibrary.org/obo/GO_0046461 GO:0046460 biolink:BiologicalProcess neutral lipid biosynthetic process The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. go.json neutral lipid anabolism|neutral lipid biosynthesis|neutral lipid formation|neutral lipid synthesis http://purl.obolibrary.org/obo/GO_0046460 GO:0046469 biolink:BiologicalProcess platelet activating factor metabolic process The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. go.json PAF metabolic process|PAF metabolism|platelet activating factor metabolism http://purl.obolibrary.org/obo/GO_0046469 GO:0046468 biolink:BiologicalProcess phosphatidyl-N-monomethylethanolamine metabolic process The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria. go.json PMME metabolic process|PMME metabolism|phosphatidyl-N-monomethylethanolamine metabolism http://purl.obolibrary.org/obo/GO_0046468 GO:0046467 biolink:BiologicalProcess membrane lipid biosynthetic process The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. go.json membrane lipid anabolism|membrane lipid biosynthesis|membrane lipid formation|membrane lipid synthesis http://purl.obolibrary.org/obo/GO_0046467 GO:0046466 biolink:BiologicalProcess membrane lipid catabolic process The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. go.json membrane lipid breakdown|membrane lipid catabolism|membrane lipid degradation|membrane lipid peroxidation http://purl.obolibrary.org/obo/GO_0046466 GO:0046465 biolink:BiologicalProcess dolichyl diphosphate metabolic process The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes. go.json dolichyl diphosphate metabolism http://purl.obolibrary.org/obo/GO_0046465 GO:0046464 biolink:BiologicalProcess acylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. go.json acylglycerol breakdown|acylglycerol catabolism|acylglycerol degradation http://purl.obolibrary.org/obo/GO_0046464 GO:0046463 biolink:BiologicalProcess acylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. go.json acylglycerol anabolism|acylglycerol biosynthesis|acylglycerol formation|acylglycerol synthesis http://purl.obolibrary.org/obo/GO_0046463 GO:0071429 biolink:BiologicalProcess obsolete snRNA-containing ribonucleoprotein complex export from nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm. go.json snRNA-containing RNP export from nucleus|snRNA-containing ribonucleoprotein complex export from cell nucleus|snRNA-containing ribonucleoprotein complex nucleus export|snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm True http://purl.obolibrary.org/obo/GO_0071429 GO:0071428 biolink:BiologicalProcess obsolete rRNA-containing ribonucleoprotein complex export from nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. go.json rRNA-containing RNP export from nucleus|rRNA-containing ribonucleoprotein complex export from cell nucleus|rRNA-containing ribonucleoprotein complex nucleus export|rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm True http://purl.obolibrary.org/obo/GO_0071428 GO:0071427 biolink:BiologicalProcess obsolete mRNA-containing ribonucleoprotein complex export from nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm. go.json mRNA-containing RNP export from nucleus|mRNA-containing ribonucleoprotein complex export from cell nucleus|mRNA-containing ribonucleoprotein complex nucleus export|mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm True http://purl.obolibrary.org/obo/GO_0071427 GO:0071426 biolink:BiologicalProcess obsolete ribonucleoprotein complex export from nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm. go.json RNP export from nucleus|ribonucleoprotein complex export from cell nucleus|ribonucleoprotein complex nucleus export|ribonucleoprotein complex transport from nucleus to cytoplasm True http://purl.obolibrary.org/obo/GO_0071426 GO:0071425 biolink:BiologicalProcess hematopoietic stem cell proliferation The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. go.json hemopoietic stem cell proliferation http://purl.obolibrary.org/obo/GO_0071425 GO:0071424 biolink:MolecularActivity rRNA (cytosine-N4-)-methyltransferase activity Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. RHEA:62520 go.json http://purl.obolibrary.org/obo/GO_0071424 GO:0071423 biolink:BiologicalProcess malate transmembrane transport A process in which a malate ion is transported across a membrane. go.json malate membrane transport|transmembrane malate transport http://purl.obolibrary.org/obo/GO_0071423 GO:0071422 biolink:BiologicalProcess succinate transmembrane transport The process in which succinate is transported across a membrane. go.json succinate membrane transport|transmembrane succinate transport http://purl.obolibrary.org/obo/GO_0071422 GO:0071421 biolink:BiologicalProcess manganese ion transmembrane transport A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json manganese ion membrane transport|transmembrane manganese transport http://purl.obolibrary.org/obo/GO_0071421 GO:0071420 biolink:BiologicalProcess cellular response to histamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. go.json cellular response to histamine stimulus http://purl.obolibrary.org/obo/GO_0071420 GO:1900309 biolink:BiologicalProcess regulation of maltoheptaose metabolic process Any process that modulates the frequency, rate or extent of maltoheptaose metabolic process. go.json regulation of maltoheptaose metabolism http://purl.obolibrary.org/obo/GO_1900309 GO:0046473 biolink:BiologicalProcess phosphatidic acid metabolic process The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. go.json phosphatidic acid metabolism http://purl.obolibrary.org/obo/GO_0046473 GO:1900308 biolink:BiologicalProcess positive regulation of maltoheptaose transport Any process that activates or increases the frequency, rate or extent of maltoheptaose transport. go.json activation of maltoheptaose transport|up regulation of maltoheptaose transport|up-regulation of maltoheptaose transport|upregulation of maltoheptaose transport http://purl.obolibrary.org/obo/GO_1900308 GO:0046472 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046472 GO:0046471 biolink:BiologicalProcess phosphatidylglycerol metabolic process The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. go.json phosphatidylglycerol metabolism http://purl.obolibrary.org/obo/GO_0046471 GO:0046470 biolink:BiologicalProcess phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. go.json phosphatidylcholine metabolism http://purl.obolibrary.org/obo/GO_0046470 GO:1900305 biolink:BiologicalProcess positive regulation of laminaritriose transport Any process that activates or increases the frequency, rate or extent of laminaritriose transport. go.json activation of laminaritriose transport|up regulation of laminaritriose transport|up-regulation of laminaritriose transport|upregulation of laminaritriose transport http://purl.obolibrary.org/obo/GO_1900305 GO:1900304 biolink:BiologicalProcess negative regulation of laminaritriose transport Any process that stops, prevents or reduces the frequency, rate or extent of laminaritriose transport. go.json down regulation of laminaritriose transport|down-regulation of laminaritriose transport|downregulation of laminaritriose transport|inhibition of laminaritriose transport http://purl.obolibrary.org/obo/GO_1900304 GO:1900307 biolink:BiologicalProcess negative regulation of maltoheptaose transport Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose transport. go.json down regulation of maltoheptaose transport|down-regulation of maltoheptaose transport|downregulation of maltoheptaose transport|inhibition of maltoheptaose transport http://purl.obolibrary.org/obo/GO_1900307 GO:1900306 biolink:BiologicalProcess regulation of maltoheptaose transport Any process that modulates the frequency, rate or extent of maltoheptaose transport. go.json http://purl.obolibrary.org/obo/GO_1900306 GO:1900301 biolink:BiologicalProcess obsolete negative regulation of laminarabiose transport OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of laminarabiose transport. go.json down regulation of laminarabiose transport|down-regulation of laminarabiose transport|downregulation of laminarabiose transport|inhibition of laminarabiose transport True http://purl.obolibrary.org/obo/GO_1900301 GO:1900300 biolink:BiologicalProcess obsolete regulation of laminarabiose transport OBSOLETE. Any process that modulates the frequency, rate or extent of laminarabiose transport. go.json True http://purl.obolibrary.org/obo/GO_1900300 GO:0046479 biolink:BiologicalProcess glycosphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. go.json glycosphingolipid breakdown|glycosphingolipid catabolism|glycosphingolipid degradation http://purl.obolibrary.org/obo/GO_0046479 GO:1900303 biolink:BiologicalProcess regulation of laminaritriose transport Any process that modulates the frequency, rate or extent of laminaritriose transport. go.json http://purl.obolibrary.org/obo/GO_1900303 GO:1900302 biolink:BiologicalProcess obsolete positive regulation of laminarabiose transport OBSOLETE. Any process that activates or increases the frequency, rate or extent of laminarabiose transport. go.json activation of laminarabiose transport|up regulation of laminarabiose transport|up-regulation of laminarabiose transport|upregulation of laminarabiose transport True http://purl.obolibrary.org/obo/GO_1900302 GO:0046478 biolink:BiologicalProcess lactosylceramide metabolic process The chemical reactions and pathways involving lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. go.json lactosylceramide metabolism http://purl.obolibrary.org/obo/GO_0046478 GO:0046477 biolink:BiologicalProcess glycosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. go.json glycosylceramide breakdown|glycosylceramide catabolism|glycosylceramide degradation http://purl.obolibrary.org/obo/GO_0046477 GO:0046476 biolink:BiologicalProcess glycosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. go.json glycosylceramide anabolism|glycosylceramide biosynthesis|glycosylceramide formation|glycosylceramide synthesis http://purl.obolibrary.org/obo/GO_0046476 GO:0046475 biolink:BiologicalProcess glycerophospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. go.json glycerophospholipid breakdown|glycerophospholipid catabolism|glycerophospholipid degradation|phosphoglyceride catabolic process|phosphoglyceride catabolism http://purl.obolibrary.org/obo/GO_0046475 GO:0046474 biolink:BiologicalProcess glycerophospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. go.json glycerophospholipid anabolism|glycerophospholipid biosynthesis|glycerophospholipid formation|glycerophospholipid synthesis|phosphoglyceride biosynthesis|phosphoglyceride biosynthetic process http://purl.obolibrary.org/obo/GO_0046474 GO:0071419 biolink:BiologicalProcess cellular response to amphetamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. go.json http://purl.obolibrary.org/obo/GO_0071419 GO:0071418 biolink:BiologicalProcess cellular response to amine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. go.json http://purl.obolibrary.org/obo/GO_0071418 GO:0071417 biolink:BiologicalProcess cellular response to organonitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. go.json cellular response to organic nitrogen http://purl.obolibrary.org/obo/GO_0071417 GO:0071416 biolink:BiologicalProcess cellular response to tropane Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine. go.json http://purl.obolibrary.org/obo/GO_0071416 GO:0071415 biolink:BiologicalProcess cellular response to purine-containing compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. go.json cellular response to purine http://purl.obolibrary.org/obo/GO_0071415 GO:0071414 biolink:BiologicalProcess cellular response to methotrexate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase. go.json http://purl.obolibrary.org/obo/GO_0071414 GO:0071413 biolink:BiologicalProcess cellular response to hydroxyisoflavone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071413 GO:0071412 biolink:BiologicalProcess cellular response to genistein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. go.json http://purl.obolibrary.org/obo/GO_0071412 GO:0071411 biolink:BiologicalProcess cellular response to fluoxetine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor. go.json http://purl.obolibrary.org/obo/GO_0071411 gocheck_do_not_manually_annotate GO:0071410 biolink:BiologicalProcess cellular response to cyclopentenone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid. go.json http://purl.obolibrary.org/obo/GO_0071410 GO:0071440 biolink:BiologicalProcess obsolete regulation of histone H3-K14 acetylation OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. go.json regulation of histone H3 acetylation at K14|regulation of histone H3K14 acetylation True http://purl.obolibrary.org/obo/GO_0071440 GO:0046484 biolink:BiologicalProcess oxazole or thiazole metabolic process The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. go.json oxazole or thiazole metabolism http://purl.obolibrary.org/obo/GO_0046484 GO:1900319 biolink:BiologicalProcess negative regulation of methane biosynthetic process from dimethylamine Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine. go.json down regulation of methane biosynthetic process from dimethylamine|down-regulation of methane biosynthetic process from dimethylamine|downregulation of methane biosynthetic process from dimethylamine|inhibition of methane biosynthetic process from dimethylamine http://purl.obolibrary.org/obo/GO_1900319 GO:0046483 biolink:BiologicalProcess heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). go.json heterocycle metabolism http://purl.obolibrary.org/obo/GO_0046483 goslim_pir GO:0046482 biolink:BiologicalProcess para-aminobenzoic acid metabolic process The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. go.json 4-aminobenzoic acid metabolic process|4-aminobenzoic acid metabolism|PABA metabolic process|PABA metabolism|p-aminobenzoic acid metabolic process|p-aminobenzoic acid metabolism|para-aminobenzoic acid metabolism|vitamin Bx metabolic process|vitamin Bx metabolism http://purl.obolibrary.org/obo/GO_0046482 GO:0046481 biolink:MolecularActivity digalactosyldiacylglycerol synthase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H+ + UDP. EC:2.4.1.241|KEGG_REACTION:R04469|MetaCyc:RXN-1225|RHEA:10520|Wikipedia:Digalactosyldiacylglycerol_synthase go.json DGD1|DGD2|DGDG synthase activity|UDP-galactose-dependent DGDG synthase activity|UDP-galactose-dependent digalactosyldiacylglycerol synthase activity|UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity|UDP-galactose:MGDG galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0046481 GO:1900316 biolink:BiologicalProcess negative regulation of maltopentaose transport Any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport. go.json down regulation of maltopentaose transport|down-regulation of maltopentaose transport|downregulation of maltopentaose transport|inhibition of maltopentaose transport http://purl.obolibrary.org/obo/GO_1900316 GO:0046480 biolink:MolecularActivity galactolipid galactosyltransferase activity Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol. EC:2.4.1.184|MetaCyc:RXN-1226|RHEA:15921 go.json 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity|DGDG synthase activity|GGGT activity|digalactosyldiacylglycerol synthase activity|galactolipid-galactolipid galactosyltransferase activity|galactolipid:galactolipid galactosyltransferase activity|interlipid galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0046480 GO:1900315 biolink:BiologicalProcess regulation of maltopentaose transport Any process that modulates the frequency, rate or extent of maltopentaose transport. go.json http://purl.obolibrary.org/obo/GO_1900315 GO:1900318 biolink:BiologicalProcess regulation of methane biosynthetic process from dimethylamine Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine. go.json http://purl.obolibrary.org/obo/GO_1900318 GO:1900317 biolink:BiologicalProcess positive regulation of maltopentaose transport Any process that activates or increases the frequency, rate or extent of maltopentaose transport. go.json activation of maltopentaose transport|up regulation of maltopentaose transport|up-regulation of maltopentaose transport|upregulation of maltopentaose transport http://purl.obolibrary.org/obo/GO_1900317 GO:1900312 biolink:BiologicalProcess regulation of maltohexaose transport Any process that modulates the frequency, rate or extent of maltohexaose transport. go.json http://purl.obolibrary.org/obo/GO_1900312 GO:1900311 biolink:BiologicalProcess positive regulation of maltoheptaose metabolic process Any process that activates or increases the frequency, rate or extent of maltoheptaose metabolic process. go.json activation of maltoheptaose metabolic process|activation of maltoheptaose metabolism|positive regulation of maltoheptaose metabolism|up regulation of maltoheptaose metabolic process|up regulation of maltoheptaose metabolism|up-regulation of maltoheptaose metabolic process|up-regulation of maltoheptaose metabolism|upregulation of maltoheptaose metabolic process|upregulation of maltoheptaose metabolism http://purl.obolibrary.org/obo/GO_1900311 GO:1900314 biolink:BiologicalProcess positive regulation of maltohexaose transport Any process that activates or increases the frequency, rate or extent of maltohexaose transport. go.json activation of maltohexaose transport|up regulation of maltohexaose transport|up-regulation of maltohexaose transport|upregulation of maltohexaose transport http://purl.obolibrary.org/obo/GO_1900314 GO:0046489 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046489 GO:1900313 biolink:BiologicalProcess negative regulation of maltohexaose transport Any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport. go.json down regulation of maltohexaose transport|down-regulation of maltohexaose transport|downregulation of maltohexaose transport|inhibition of maltohexaose transport http://purl.obolibrary.org/obo/GO_1900313 GO:0046488 biolink:BiologicalProcess phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. go.json PtdIns metabolic process|PtdIns metabolism|phosphatidylinositol metabolism|phosphoinositide metabolic process|phosphoinositide metabolism http://purl.obolibrary.org/obo/GO_0046488 GO:0046487 biolink:BiologicalProcess glyoxylate metabolic process The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. go.json glyoxylate metabolism http://purl.obolibrary.org/obo/GO_0046487 GO:1900310 biolink:BiologicalProcess negative regulation of maltoheptaose metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process. go.json down regulation of maltoheptaose metabolic process|down regulation of maltoheptaose metabolism|down-regulation of maltoheptaose metabolic process|down-regulation of maltoheptaose metabolism|downregulation of maltoheptaose metabolic process|downregulation of maltoheptaose metabolism|inhibition of maltoheptaose metabolic process|inhibition of maltoheptaose metabolism|negative regulation of maltoheptaose metabolism http://purl.obolibrary.org/obo/GO_1900310 GO:0046486 biolink:BiologicalProcess glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. go.json glycerolipid metabolism http://purl.obolibrary.org/obo/GO_0046486 GO:0046485 biolink:BiologicalProcess ether lipid metabolic process The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. Wikipedia:Ether_lipid go.json ether lipid metabolism|plasmalogen metabolic process http://purl.obolibrary.org/obo/GO_0046485 GO:0071449 biolink:BiologicalProcess cellular response to lipid hydroperoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids. go.json cellular response to LHPO http://purl.obolibrary.org/obo/GO_0071449 GO:0071448 biolink:BiologicalProcess cellular response to alkyl hydroperoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group. go.json http://purl.obolibrary.org/obo/GO_0071448 GO:0071447 biolink:BiologicalProcess cellular response to hydroperoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. go.json http://purl.obolibrary.org/obo/GO_0071447 GO:0071446 biolink:BiologicalProcess cellular response to salicylic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. go.json cellular response to salicylate stimulus http://purl.obolibrary.org/obo/GO_0071446 GO:0071445 biolink:BiologicalProcess obsolete cellular response to protein stimulus OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus. go.json cellular response to protein stimulus True http://purl.obolibrary.org/obo/GO_0071445 GO:0071444 biolink:BiologicalProcess cellular response to pheromone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. go.json cellular pheromone response http://purl.obolibrary.org/obo/GO_0071444 GO:0071443 biolink:MolecularActivity tDNA binding Binding to DNA sequences encoding transfer RNA. go.json http://purl.obolibrary.org/obo/GO_0071443 GO:0071442 biolink:BiologicalProcess obsolete positive regulation of histone H3-K14 acetylation OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. go.json activation of histone H3-K14 acetylation|positive regulation of histone H3 acetylation at K14|positive regulation of histone H3K14 acetylation|stimulation of histone H3-K14 acetylation|up regulation of histone H3-K14 acetylation|up-regulation of histone H3-K14 acetylation|upregulation of histone H3-K14 acetylation True http://purl.obolibrary.org/obo/GO_0071442 GO:0071441 biolink:BiologicalProcess obsolete negative regulation of histone H3-K14 acetylation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. go.json down regulation of histone H3-K14 acetylation|down-regulation of histone H3-K14 acetylation|downregulation of histone H3-K14 acetylation|inhibition of histone H3-K14 acetylation|negative regulation of histone H3 acetylation at K14|negative regulation of histone H3K14 acetylation True http://purl.obolibrary.org/obo/GO_0071441 GO:0046495 biolink:BiologicalProcess nicotinamide riboside metabolic process The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. go.json N-ribosylnicotinamide metabolic process|nicotinamide riboside metabolism http://purl.obolibrary.org/obo/GO_0046495 GO:0046494 biolink:BiologicalProcess rhizobactin 1021 metabolic process The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. go.json rhizobactin 1021 metabolism http://purl.obolibrary.org/obo/GO_0046494 GO:0046493 biolink:BiologicalProcess lipid A metabolic process The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. go.json lipid A metabolism http://purl.obolibrary.org/obo/GO_0046493 GO:0046492 biolink:BiologicalProcess heme B metabolic process The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. go.json haem B metabolic process|haem B metabolism|heme B metabolism|protoheme metabolic process|protoheme metabolism http://purl.obolibrary.org/obo/GO_0046492 GO:0046491 biolink:BiologicalProcess L-methylmalonyl-CoA metabolic process The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals. go.json L-methylmalonyl-CoA metabolism http://purl.obolibrary.org/obo/GO_0046491 GO:1900327 biolink:BiologicalProcess regulation of mannotriose transport Any process that modulates the frequency, rate or extent of mannotriose transport. go.json http://purl.obolibrary.org/obo/GO_1900327 GO:1900326 biolink:BiologicalProcess positive regulation of maltotriulose transport Any process that activates or increases the frequency, rate or extent of maltotriulose transport. go.json activation of maltotriulose transport|up regulation of maltotriulose transport|up-regulation of maltotriulose transport|upregulation of maltotriulose transport http://purl.obolibrary.org/obo/GO_1900326 GO:0046490 biolink:BiologicalProcess isopentenyl diphosphate metabolic process The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. go.json IPP metabolic process|IPP metabolism|isopentenyl diphosphate metabolism|isopentenyl pyrophosphate metabolic process|isopentenyl pyrophosphate metabolism http://purl.obolibrary.org/obo/GO_0046490 goslim_pir GO:1900329 biolink:BiologicalProcess positive regulation of mannotriose transport Any process that activates or increases the frequency, rate or extent of mannotriose transport. go.json activation of mannotriose transport|up regulation of mannotriose transport|up-regulation of mannotriose transport|upregulation of mannotriose transport http://purl.obolibrary.org/obo/GO_1900329 GO:1900328 biolink:BiologicalProcess negative regulation of mannotriose transport Any process that stops, prevents or reduces the frequency, rate or extent of mannotriose transport. go.json down regulation of mannotriose transport|down-regulation of mannotriose transport|downregulation of mannotriose transport|inhibition of mannotriose transport http://purl.obolibrary.org/obo/GO_1900328 GO:1900323 biolink:BiologicalProcess positive regulation of maltotetraose transport Any process that activates or increases the frequency, rate or extent of maltotetraose transport. go.json activation of maltotetraose transport|up regulation of maltotetraose transport|up-regulation of maltotetraose transport|upregulation of maltotetraose transport http://purl.obolibrary.org/obo/GO_1900323 GO:1900322 biolink:BiologicalProcess negative regulation of maltotetraose transport Any process that stops, prevents or reduces the frequency, rate or extent of maltotetraose transport. go.json down regulation of maltotetraose transport|down-regulation of maltotetraose transport|downregulation of maltotetraose transport|inhibition of maltotetraose transport http://purl.obolibrary.org/obo/GO_1900322 GO:1900325 biolink:BiologicalProcess negative regulation of maltotriulose transport Any process that stops, prevents or reduces the frequency, rate or extent of maltotriulose transport. go.json down regulation of maltotriulose transport|down-regulation of maltotriulose transport|downregulation of maltotriulose transport|inhibition of maltotriulose transport http://purl.obolibrary.org/obo/GO_1900325 GO:1900324 biolink:BiologicalProcess regulation of maltotriulose transport Any process that modulates the frequency, rate or extent of maltotriulose transport. go.json http://purl.obolibrary.org/obo/GO_1900324 GO:0046499 biolink:BiologicalProcess S-adenosylmethioninamine metabolic process The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. go.json S-adenosylmethioninamine metabolism http://purl.obolibrary.org/obo/GO_0046499 GO:0046498 biolink:BiologicalProcess S-adenosylhomocysteine metabolic process The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. go.json S-adenosylhomocysteine metabolism http://purl.obolibrary.org/obo/GO_0046498 GO:1900321 biolink:BiologicalProcess regulation of maltotetraose transport Any process that modulates the frequency, rate or extent of maltotetraose transport. go.json http://purl.obolibrary.org/obo/GO_1900321 GO:0046497 biolink:BiologicalProcess nicotinate nucleotide metabolic process The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin). go.json nicotinate nucleotide metabolism http://purl.obolibrary.org/obo/GO_0046497 GO:0046496 biolink:BiologicalProcess nicotinamide nucleotide metabolic process The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. go.json nicotinamide nucleotide metabolism http://purl.obolibrary.org/obo/GO_0046496 GO:1900320 biolink:BiologicalProcess positive regulation of methane biosynthetic process from dimethylamine Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine. go.json activation of methane biosynthetic process from dimethylamine|up regulation of methane biosynthetic process from dimethylamine|up-regulation of methane biosynthetic process from dimethylamine|upregulation of methane biosynthetic process from dimethylamine http://purl.obolibrary.org/obo/GO_1900320 GO:0071439 biolink:CellularComponent clathrin complex A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. go.json clathrin triskelion http://purl.obolibrary.org/obo/GO_0071439 GO:0071438 biolink:CellularComponent obsolete invadopodium membrane OBSOLETE. The portion of the plasma membrane surrounding an invadopodium. go.json True http://purl.obolibrary.org/obo/GO_0071438 GO:0071437 biolink:CellularComponent obsolete invadopodium OBSOLETE. A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. go.json True http://purl.obolibrary.org/obo/GO_0071437 GO:0071436 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071436 GO:0071435 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071435 GO:0071434 biolink:BiologicalProcess cell chemotaxis to angiotensin The directed movement of a motile cell in response to the presence of angiotensin. go.json angiotensin mediated chemotaxis|angiotensin-mediated cell chemotaxis http://purl.obolibrary.org/obo/GO_0071434 GO:0071433 biolink:BiologicalProcess cell wall repair A process of cell wall organization that results in the restoration of the cell wall following damage. go.json http://purl.obolibrary.org/obo/GO_0071433 GO:0071432 biolink:BiologicalProcess peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion. go.json a-factor processing (proteolytic)|alpha-factor maturation|mating-type peptide pheromone maturation involved in conjugation with cellular fusion|peptide mating pheromone formation involved in conjugation with cellular fusion|peptide mating pheromone processing involved in conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0071432 GO:0071431 biolink:BiologicalProcess obsolete tRNA-containing ribonucleoprotein complex export from nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm. go.json tRNA-containing RNP export from nucleus|tRNA-containing ribonucleoprotein complex export from cell nucleus|tRNA-containing ribonucleoprotein complex nucleus export|tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm True http://purl.obolibrary.org/obo/GO_0071431 GO:0071430 biolink:BiologicalProcess obsolete pre-miRNA-containing ribonucleoprotein complex export from nucleus OBSOLETE. The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm. go.json pre-microRNA-containing RNP export from nucleus|pre-microRNA-containing ribonucleoprotein complex export from cell nucleus|pre-microRNA-containing ribonucleoprotein complex export from nucleus|pre-microRNA-containing ribonucleoprotein complex nucleus export|pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm True http://purl.obolibrary.org/obo/GO_0071430 GO:0071462 biolink:BiologicalProcess cellular response to water stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. go.json http://purl.obolibrary.org/obo/GO_0071462 GO:0071461 biolink:BiologicalProcess cellular response to redox state Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. go.json cellular redox signal response http://purl.obolibrary.org/obo/GO_0071461 GO:0071460 biolink:BiologicalProcess cellular response to cell-matrix adhesion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion. go.json http://purl.obolibrary.org/obo/GO_0071460 GO:1900338 biolink:BiologicalProcess positive regulation of methane biosynthetic process from carbon monoxide Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide. go.json activation of methane biosynthetic process from carbon monoxide|up regulation of methane biosynthetic process from carbon monoxide|up-regulation of methane biosynthetic process from carbon monoxide|upregulation of methane biosynthetic process from carbon monoxide http://purl.obolibrary.org/obo/GO_1900338 OIO:hasExactSynonym biolink:OntologyClass has_exact_synonym go.json http://www.geneontology.org/formats/oboInOwl#hasExactSynonym GO:1900337 biolink:BiologicalProcess negative regulation of methane biosynthetic process from carbon monoxide Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from carbon monoxide. go.json down regulation of methane biosynthetic process from carbon monoxide|down-regulation of methane biosynthetic process from carbon monoxide|downregulation of methane biosynthetic process from carbon monoxide|inhibition of methane biosynthetic process from carbon monoxide http://purl.obolibrary.org/obo/GO_1900337 GO:1900339 biolink:BiologicalProcess regulation of methane biosynthetic process from formic acid Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid. go.json http://purl.obolibrary.org/obo/GO_1900339 GO:1900334 biolink:BiologicalProcess negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid. go.json down regulation of methane biosynthetic process from 3-(methylthio)propionic acid|down-regulation of methane biosynthetic process from 3-(methylthio)propionic acid|downregulation of methane biosynthetic process from 3-(methylthio)propionic acid|inhibition of methane biosynthetic process from 3-(methylthio)propionic acid http://purl.obolibrary.org/obo/GO_1900334 GO:1900333 biolink:BiologicalProcess regulation of methane biosynthetic process from 3-(methylthio)propionic acid Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid. go.json http://purl.obolibrary.org/obo/GO_1900333 GO:1900336 biolink:BiologicalProcess regulation of methane biosynthetic process from carbon monoxide Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide. go.json http://purl.obolibrary.org/obo/GO_1900336 GO:1900335 biolink:BiologicalProcess positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid. go.json activation of methane biosynthetic process from 3-(methylthio)propionic acid|up regulation of methane biosynthetic process from 3-(methylthio)propionic acid|up-regulation of methane biosynthetic process from 3-(methylthio)propionic acid|upregulation of methane biosynthetic process from 3-(methylthio)propionic acid http://purl.obolibrary.org/obo/GO_1900335 GO:1900330 biolink:BiologicalProcess regulation of methane biosynthetic process from trimethylamine Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine. go.json http://purl.obolibrary.org/obo/GO_1900330 GO:1900332 biolink:BiologicalProcess positive regulation of methane biosynthetic process from trimethylamine Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine. go.json activation of methane biosynthetic process from trimethylamine|up regulation of methane biosynthetic process from trimethylamine|up-regulation of methane biosynthetic process from trimethylamine|upregulation of methane biosynthetic process from trimethylamine http://purl.obolibrary.org/obo/GO_1900332 GO:1900331 biolink:BiologicalProcess negative regulation of methane biosynthetic process from trimethylamine Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine. go.json down regulation of methane biosynthetic process from trimethylamine|down-regulation of methane biosynthetic process from trimethylamine|downregulation of methane biosynthetic process from trimethylamine|inhibition of methane biosynthetic process from trimethylamine http://purl.obolibrary.org/obo/GO_1900331 GO:0071469 biolink:BiologicalProcess cellular response to alkaline pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. go.json cellular response to alkalinity|cellular response to basic pH http://purl.obolibrary.org/obo/GO_0071469 GO:0071468 biolink:BiologicalProcess cellular response to acidic pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. go.json cellular response to acidity http://purl.obolibrary.org/obo/GO_0071468 GO:0071467 biolink:BiologicalProcess cellular response to pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. go.json http://purl.obolibrary.org/obo/GO_0071467 GO:0071466 biolink:BiologicalProcess cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json cellular response to drug http://purl.obolibrary.org/obo/GO_0071466 goslim_chembl GO:0071465 biolink:BiologicalProcess cellular response to desiccation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. go.json desiccation tolerance http://purl.obolibrary.org/obo/GO_0071465 GO:0071464 biolink:BiologicalProcess cellular response to hydrostatic pressure Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. go.json cellular response to biomechanical stress|cellular response to static fluid pressure http://purl.obolibrary.org/obo/GO_0071464 GO:0071463 biolink:BiologicalProcess cellular response to humidity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. go.json http://purl.obolibrary.org/obo/GO_0071463 GO:0071451 biolink:BiologicalProcess cellular response to superoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. go.json http://purl.obolibrary.org/obo/GO_0071451 GO:0071450 biolink:BiologicalProcess cellular response to oxygen radical Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. go.json http://purl.obolibrary.org/obo/GO_0071450 GO:1900349 biolink:BiologicalProcess negative regulation of methane biosynthetic process from methylamine Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine. go.json down regulation of methane biosynthetic process from methylamine|down-regulation of methane biosynthetic process from methylamine|downregulation of methane biosynthetic process from methylamine|inhibition of methane biosynthetic process from methylamine http://purl.obolibrary.org/obo/GO_1900349 GO:1900348 biolink:BiologicalProcess regulation of methane biosynthetic process from methylamine Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine. go.json http://purl.obolibrary.org/obo/GO_1900348 GO:1900345 biolink:BiologicalProcess regulation of methane biosynthetic process from methanethiol Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol. go.json http://purl.obolibrary.org/obo/GO_1900345 GO:1900344 biolink:BiologicalProcess positive regulation of methane biosynthetic process from dimethyl sulfide Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide. go.json activation of methane biosynthetic process from dimethyl sulfide|up regulation of methane biosynthetic process from dimethyl sulfide|up-regulation of methane biosynthetic process from dimethyl sulfide|upregulation of methane biosynthetic process from dimethyl sulfide http://purl.obolibrary.org/obo/GO_1900344 GO:1900347 biolink:BiologicalProcess positive regulation of methane biosynthetic process from methanethiol Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol. go.json activation of methane biosynthetic process from methanethiol|up regulation of methane biosynthetic process from methanethiol|up-regulation of methane biosynthetic process from methanethiol|upregulation of methane biosynthetic process from methanethiol http://purl.obolibrary.org/obo/GO_1900347 GO:1900346 biolink:BiologicalProcess negative regulation of methane biosynthetic process from methanethiol Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methanethiol. go.json down regulation of methane biosynthetic process from methanethiol|down-regulation of methane biosynthetic process from methanethiol|downregulation of methane biosynthetic process from methanethiol|inhibition of methane biosynthetic process from methanethiol http://purl.obolibrary.org/obo/GO_1900346 GO:1900341 biolink:BiologicalProcess positive regulation of methane biosynthetic process from formic acid Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid. go.json activation of methane biosynthetic process from formic acid|up regulation of methane biosynthetic process from formic acid|up-regulation of methane biosynthetic process from formic acid|upregulation of methane biosynthetic process from formic acid http://purl.obolibrary.org/obo/GO_1900341 GO:1900340 biolink:BiologicalProcess negative regulation of methane biosynthetic process from formic acid Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid. go.json down regulation of methane biosynthetic process from formic acid|down-regulation of methane biosynthetic process from formic acid|downregulation of methane biosynthetic process from formic acid|inhibition of methane biosynthetic process from formic acid http://purl.obolibrary.org/obo/GO_1900340 GO:1900343 biolink:BiologicalProcess negative regulation of methane biosynthetic process from dimethyl sulfide Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide. go.json down regulation of methane biosynthetic process from dimethyl sulfide|down-regulation of methane biosynthetic process from dimethyl sulfide|downregulation of methane biosynthetic process from dimethyl sulfide|inhibition of methane biosynthetic process from dimethyl sulfide http://purl.obolibrary.org/obo/GO_1900343 GO:1900342 biolink:BiologicalProcess regulation of methane biosynthetic process from dimethyl sulfide Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide. go.json http://purl.obolibrary.org/obo/GO_1900342 GO:1900350 biolink:BiologicalProcess positive regulation of methane biosynthetic process from methylamine Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methylamine. go.json activation of methane biosynthetic process from methylamine|up regulation of methane biosynthetic process from methylamine|up-regulation of methane biosynthetic process from methylamine|upregulation of methane biosynthetic process from methylamine http://purl.obolibrary.org/obo/GO_1900350 GO:0071459 biolink:BiologicalProcess protein localization to chromosome, centromeric region Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. go.json protein localisation to chromosome, centromeric region|protein localization to centromere|protein localization to chromosome, centric region http://purl.obolibrary.org/obo/GO_0071459 GO:0071458 biolink:CellularComponent obsolete integral component of cytoplasmic side of endoplasmic reticulum membrane OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane. go.json integral to ER membrane, cytosolic side|integral to cytosolic leaflet of endoplasmic reticulum membrane|integral to cytosolic side of ER membrane|integral to cytosolic side of endoplasmic reticulum membrane True http://purl.obolibrary.org/obo/GO_0071458 GO:0071457 biolink:BiologicalProcess cellular response to ozone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071457 GO:0071456 biolink:BiologicalProcess cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. go.json cellular response to hypoxic stress|cellular response to lowered oxygen tension http://purl.obolibrary.org/obo/GO_0071456 GO:0071455 biolink:BiologicalProcess cellular response to hyperoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. go.json cellular response to hyperoxic stress|cellular response to increased oxygen tension http://purl.obolibrary.org/obo/GO_0071455 GO:0071454 biolink:BiologicalProcess cellular response to anoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. go.json cellular response to anaerobic conditions|cellular response to anoxic stress http://purl.obolibrary.org/obo/GO_0071454 GO:0071453 biolink:BiologicalProcess cellular response to oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. go.json cellular response to oxygen http://purl.obolibrary.org/obo/GO_0071453 GO:0071452 biolink:BiologicalProcess cellular response to singlet oxygen Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. go.json http://purl.obolibrary.org/obo/GO_0071452 GO:0046602 biolink:BiologicalProcess regulation of mitotic centrosome separation Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis. go.json http://purl.obolibrary.org/obo/GO_0046602 GO:0046601 biolink:BiologicalProcess positive regulation of centriole replication Any process that activates or increases the frequency, rate or extent of centriole replication. go.json activation of centriole replication|stimulation of centriole replication|up regulation of centriole replication|up-regulation of centriole replication|upregulation of centriole replication http://purl.obolibrary.org/obo/GO_0046601 GO:0046600 biolink:BiologicalProcess negative regulation of centriole replication Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication. go.json down regulation of centriole replication|down-regulation of centriole replication|downregulation of centriole replication|inhibition of centriole replication http://purl.obolibrary.org/obo/GO_0046600 GO:0046609 biolink:MolecularActivity obsolete voltage-gated sulfate antiporter activity OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential. go.json prestin|voltage gated sulfate antiporter activity|voltage-dependent sulfate antiporter activity|voltage-sensitive sulfate antiporter activity|voltage-sensitive sulphate antiporter activity True http://purl.obolibrary.org/obo/GO_0046609 GO:0046608 biolink:MolecularActivity carotenoid isomerase activity Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids. go.json http://purl.obolibrary.org/obo/GO_0046608 GO:0046607 biolink:BiologicalProcess positive regulation of centrosome cycle Any process that activates or increases the frequency, rate or extent of the centrosome cycle. go.json activation of centrosome cycle|stimulation of centrosome cycle|up regulation of centrosome cycle|up-regulation of centrosome cycle|upregulation of centrosome cycle http://purl.obolibrary.org/obo/GO_0046607 GO:0046606 biolink:BiologicalProcess negative regulation of centrosome cycle Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle. go.json down regulation of centrosome cycle|down-regulation of centrosome cycle|downregulation of centrosome cycle|inhibition of centrosome cycle http://purl.obolibrary.org/obo/GO_0046606 GO:0046605 biolink:BiologicalProcess regulation of centrosome cycle Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. go.json http://purl.obolibrary.org/obo/GO_0046605 GO:0046604 biolink:BiologicalProcess positive regulation of mitotic centrosome separation Any process that activates or increases the frequency, rate or extent of centrosome separation. go.json activation of mitotic centrosome separation|stimulation of mitotic centrosome separation|up regulation of mitotic centrosome separation|up-regulation of mitotic centrosome separation|upregulation of mitotic centrosome separation http://purl.obolibrary.org/obo/GO_0046604 GO:0046603 biolink:BiologicalProcess negative regulation of mitotic centrosome separation Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation. go.json down regulation of mitotic centrosome separation|down-regulation of mitotic centrosome separation|downregulation of mitotic centrosome separation|inhibition of mitotic centrosome separation http://purl.obolibrary.org/obo/GO_0046603 GO:0022620 biolink:BiologicalProcess microgametophyte vegetative cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a microgametophyte. The microgametophyte vegetative cell gives rise to the pollen tube. go.json tube cell differentiation|vegetative cell differentiation http://purl.obolibrary.org/obo/GO_0022620 GO:0007009 biolink:BiologicalProcess plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. go.json plasma membrane organisation|plasma membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0007009 goslim_chembl GO:0007008 biolink:BiologicalProcess outer mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane. go.json outer mitochondrial membrane organisation|outer mitochondrial membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0007008 GO:0007007 biolink:BiologicalProcess inner mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. go.json inner mitochondrial membrane organisation|inner mitochondrial membrane organization and biogenesis|mitochondrial inner membrane organization http://purl.obolibrary.org/obo/GO_0007007 GO:0022622 biolink:BiologicalProcess root system development The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0022622 GO:0007006 biolink:BiologicalProcess mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. go.json mitochondrial membrane organisation|mitochondrial membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0007006 GO:0022621 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022621 GO:0007005 biolink:BiologicalProcess mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. go.json mitochondria organization|mitochondrion organisation|mitochondrion organization and biogenesis http://purl.obolibrary.org/obo/GO_0007005 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast GO:0046613 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046613 GO:0007004 biolink:BiologicalProcess telomere maintenance via telomerase The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. go.json telomerase-dependent telomere maintenance http://purl.obolibrary.org/obo/GO_0007004 GO:0046612 biolink:CellularComponent lysosomal proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. go.json lysosomal hydrogen ion-transporting ATPase V1 domain http://purl.obolibrary.org/obo/GO_0046612 GO:0007003 biolink:BiologicalProcess obsolete telomere binding OBSOLETE. (Was not defined before being made obsolete). go.json telomere binding True http://purl.obolibrary.org/obo/GO_0007003 GO:0046611 biolink:CellularComponent lysosomal proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen. go.json lysosomal hydrogen-translocating V-type ATPase complex|lysosomal membrane hydrogen-transporting ATPase http://purl.obolibrary.org/obo/GO_0046611 GO:0007002 biolink:BiologicalProcess obsolete centromere binding OBSOLETE. (Was not defined before being made obsolete). go.json centromere binding True http://purl.obolibrary.org/obo/GO_0007002 GO:0046610 biolink:CellularComponent lysosomal proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. go.json lysosomal hydrogen ion-transporting ATPase V0 domain http://purl.obolibrary.org/obo/GO_0046610 GO:0007001 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007001 GO:0007000 biolink:BiologicalProcess nucleolus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. go.json nucleolus organisation|nucleolus organization and biogenesis http://purl.obolibrary.org/obo/GO_0007000 GO:0046619 biolink:BiologicalProcess lens placode formation involved in camera-type eye formation Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles. go.json optic placode formation in camera-type eye|optic placode formation involved in camera-style eye|optic placode formation involved in camera-type eye formation http://purl.obolibrary.org/obo/GO_0046619 GO:0046618 biolink:BiologicalProcess xenobiotic export from cell The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. go.json drug export|xenobiotic export http://purl.obolibrary.org/obo/GO_0046618 GO:0046617 biolink:BiologicalProcess obsolete nucleolar size increase (sensu Saccharomyces) OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces. go.json nucleolar size increase (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0046617 GO:0046616 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046616 GO:0046615 biolink:BiologicalProcess obsolete re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces) OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated. go.json re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0046615 GO:0046614 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046614 GO:0022624 biolink:CellularComponent proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. go.json http://purl.obolibrary.org/obo/GO_0022624 GO:0022623 biolink:CellularComponent proteasome-activating nucleotidase complex A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner. go.json PAN http://purl.obolibrary.org/obo/GO_0022623 GO:0022626 biolink:CellularComponent cytosolic ribosome A ribosome located in the cytosol. go.json 70S ribosome|80S ribosome http://purl.obolibrary.org/obo/GO_0022626 GO:0022625 biolink:CellularComponent cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol. go.json 50S ribosomal subunit|60S ribosomal subunit|eukaryotic ribosomal LSU|prokaryotic large ribosomal subunit http://purl.obolibrary.org/obo/GO_0022625 GO:0022628 biolink:CellularComponent chloroplast large ribosomal subunit The large subunit of a ribosome contained within a chloroplast. go.json chloroplast ribosomal LSU complex|chloroplast ribosomal large subunit complex http://purl.obolibrary.org/obo/GO_0022628 GO:0022627 biolink:CellularComponent cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol. go.json 30S ribosomal subunit|40S ribosomal subunit|eukaryotic ribosomal SSU|prokaryotic small ribosomal subunit http://purl.obolibrary.org/obo/GO_0022627 GO:0022629 biolink:CellularComponent chloroplast small ribosomal subunit The small subunit of a ribosome contained within a chloroplast. go.json chloroplast ribosomal SSU complex|chloroplast ribosomal small subunit complex http://purl.obolibrary.org/obo/GO_0022629 GO:0022611 biolink:BiologicalProcess dormancy process A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated. go.json multicellular organism dormancy process|spore dormancy process http://purl.obolibrary.org/obo/GO_0022611 GO:0022610 biolink:BiologicalProcess obsolete biological adhesion OBSOLETE. The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. go.json True http://purl.obolibrary.org/obo/GO_0022610 GO:0046624 biolink:MolecularActivity sphingolipid transporter activity Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). Reactome:R-HSA-9695890 go.json http://purl.obolibrary.org/obo/GO_0046624 GO:0046623 biolink:MolecularActivity sphingolipid floppase activity Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. go.json sphingolipid flippase activity|sphingolipid floppase activity (cytosolic to exoplasmic leaftlet)|sphingolipid-translocating ATPase activity http://purl.obolibrary.org/obo/GO_0046623 GO:0046622 biolink:BiologicalProcess positive regulation of organ growth Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. go.json http://purl.obolibrary.org/obo/GO_0046622 GO:0046621 biolink:BiologicalProcess negative regulation of organ growth Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. go.json http://purl.obolibrary.org/obo/GO_0046621 GO:0046620 biolink:BiologicalProcess regulation of organ growth Any process that modulates the frequency, rate or extent of growth of an organ of an organism. go.json http://purl.obolibrary.org/obo/GO_0046620 GO:0046629 biolink:BiologicalProcess gamma-delta T cell activation The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json gamma-delta T lymphocyte activation|gamma-delta T-cell activation|gamma-delta T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0046629 GO:0046628 biolink:BiologicalProcess positive regulation of insulin receptor signaling pathway Any process that increases the frequency, rate or extent of insulin receptor signaling. go.json activation of insulin receptor signaling pathway|positive regulation of insulin receptor signalling pathway|stimulation of insulin receptor signaling pathway|up regulation of insulin receptor signaling pathway|up-regulation of insulin receptor signaling pathway|upregulation of insulin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0046628 GO:0046627 biolink:BiologicalProcess negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. go.json down regulation of insulin receptor signaling pathway|down-regulation of insulin receptor signaling pathway|downregulation of insulin receptor signaling pathway|inhibition of insulin receptor signaling pathway|negative regulation of insulin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0046627 GO:0046626 biolink:BiologicalProcess regulation of insulin receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin receptor signaling. go.json regulation of insulin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0046626 GO:0046625 biolink:MolecularActivity sphingolipid binding Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). go.json http://purl.obolibrary.org/obo/GO_0046625 GO:0022613 biolink:BiologicalProcess ribonucleoprotein complex biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. go.json RNA-protein complex biogenesis|ribonucleoprotein complex biogenesis and assembly http://purl.obolibrary.org/obo/GO_0022613 GO:0022612 biolink:BiologicalProcess gland morphogenesis The process in which the anatomical structures of a gland are generated and organized. go.json http://purl.obolibrary.org/obo/GO_0022612 GO:0022615 biolink:BiologicalProcess protein to membrane docking The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere. go.json protein-membrane docking http://purl.obolibrary.org/obo/GO_0022615 GO:0022614 biolink:BiologicalProcess membrane to membrane docking The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere. go.json membrane-membrane docking http://purl.obolibrary.org/obo/GO_0022614 GO:0022617 biolink:BiologicalProcess extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix. go.json http://purl.obolibrary.org/obo/GO_0022617 GO:0022616 biolink:BiologicalProcess DNA strand elongation The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. go.json http://purl.obolibrary.org/obo/GO_0022616 GO:0022619 biolink:BiologicalProcess generative cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte. go.json http://purl.obolibrary.org/obo/GO_0022619 GO:0022618 biolink:BiologicalProcess protein-RNA complex assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. go.json RNA-protein complex assembly|RNP complex assembly|ribonucleoprotein complex assembly http://purl.obolibrary.org/obo/GO_0022618 goslim_chembl GO:1900705 biolink:BiologicalProcess negative regulation of siderophore biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process. go.json down regulation of siderochrome biosynthesis|down regulation of siderochrome biosynthetic process|down regulation of siderophore anabolism|down regulation of siderophore biosynthesis|down regulation of siderophore biosynthetic process|down regulation of siderophore biosynthetic process, peptide formation|down regulation of siderophore biosynthetic process, peptide modification|down regulation of siderophore formation|down regulation of siderophore synthesis|down-regulation of siderochrome biosynthesis|down-regulation of siderochrome biosynthetic process|down-regulation of siderophore anabolism|down-regulation of siderophore biosynthesis|down-regulation of siderophore biosynthetic process|down-regulation of siderophore biosynthetic process, peptide formation|down-regulation of siderophore biosynthetic process, peptide modification|down-regulation of siderophore formation|down-regulation of siderophore synthesis|downregulation of siderochrome biosynthesis|downregulation of siderochrome biosynthetic process|downregulation of siderophore anabolism|downregulation of siderophore biosynthesis|downregulation of siderophore biosynthetic process|downregulation of siderophore biosynthetic process, peptide formation|downregulation of siderophore biosynthetic process, peptide modification|downregulation of siderophore formation|downregulation of siderophore synthesis|inhibition of siderochrome biosynthesis|inhibition of siderochrome biosynthetic process|inhibition of siderophore anabolism|inhibition of siderophore biosynthesis|inhibition of siderophore biosynthetic process|inhibition of siderophore biosynthetic process, peptide formation|inhibition of siderophore biosynthetic process, peptide modification|inhibition of siderophore formation|inhibition of siderophore synthesis|negative regulation of siderochrome biosynthesis|negative regulation of siderochrome biosynthetic process|negative regulation of siderophore anabolism|negative regulation of siderophore biosynthesis|negative regulation of siderophore biosynthetic process, peptide formation|negative regulation of siderophore biosynthetic process, peptide modification|negative regulation of siderophore formation|negative regulation of siderophore synthesis http://purl.obolibrary.org/obo/GO_1900705 GO:1900704 biolink:BiologicalProcess regulation of siderophore biosynthetic process Any process that modulates the frequency, rate or extent of siderophore biosynthetic process. go.json regulation of siderochrome biosynthesis|regulation of siderochrome biosynthetic process|regulation of siderophore anabolism|regulation of siderophore biosynthesis|regulation of siderophore biosynthetic process, peptide formation|regulation of siderophore biosynthetic process, peptide modification|regulation of siderophore formation|regulation of siderophore synthesis http://purl.obolibrary.org/obo/GO_1900704 GO:1900707 biolink:BiologicalProcess regulation of tensidol A biosynthetic process Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process. go.json regulation of tensidol A anabolism|regulation of tensidol A biosynthesis|regulation of tensidol A formation|regulation of tensidol A synthesis http://purl.obolibrary.org/obo/GO_1900707 GO:1900706 biolink:BiologicalProcess positive regulation of siderophore biosynthetic process Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process. go.json activation of siderochrome biosynthesis|activation of siderochrome biosynthetic process|activation of siderophore anabolism|activation of siderophore biosynthesis|activation of siderophore biosynthetic process|activation of siderophore biosynthetic process, peptide formation|activation of siderophore biosynthetic process, peptide modification|activation of siderophore formation|activation of siderophore synthesis|positive regulation of siderochrome biosynthesis|positive regulation of siderochrome biosynthetic process|positive regulation of siderophore anabolism|positive regulation of siderophore biosynthesis|positive regulation of siderophore biosynthetic process, peptide formation|positive regulation of siderophore biosynthetic process, peptide modification|positive regulation of siderophore formation|positive regulation of siderophore synthesis|up regulation of siderochrome biosynthesis|up regulation of siderochrome biosynthetic process|up regulation of siderophore anabolism|up regulation of siderophore biosynthesis|up regulation of siderophore biosynthetic process|up regulation of siderophore biosynthetic process, peptide formation|up regulation of siderophore biosynthetic process, peptide modification|up regulation of siderophore formation|up regulation of siderophore synthesis|up-regulation of siderochrome biosynthesis|up-regulation of siderochrome biosynthetic process|up-regulation of siderophore anabolism|up-regulation of siderophore biosynthesis|up-regulation of siderophore biosynthetic process|up-regulation of siderophore biosynthetic process, peptide formation|up-regulation of siderophore biosynthetic process, peptide modification|up-regulation of siderophore formation|up-regulation of siderophore synthesis|upregulation of siderochrome biosynthesis|upregulation of siderochrome biosynthetic process|upregulation of siderophore anabolism|upregulation of siderophore biosynthesis|upregulation of siderophore biosynthetic process|upregulation of siderophore biosynthetic process, peptide formation|upregulation of siderophore biosynthetic process, peptide modification|upregulation of siderophore formation|upregulation of siderophore synthesis http://purl.obolibrary.org/obo/GO_1900706 GO:1900701 biolink:BiologicalProcess regulation of orcinol biosynthetic process Any process that modulates the frequency, rate or extent of orcinol biosynthetic process. go.json regulation of orcinol anabolism|regulation of orcinol biosynthesis|regulation of orcinol formation|regulation of orcinol synthesis http://purl.obolibrary.org/obo/GO_1900701 GO:1900700 biolink:BiologicalProcess positive regulation of o-orsellinic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process. go.json activation of o-orsellinic acid anabolism|activation of o-orsellinic acid biosynthesis|activation of o-orsellinic acid biosynthetic process|activation of o-orsellinic acid formation|activation of o-orsellinic acid synthesis|positive regulation of o-orsellinic acid anabolism|positive regulation of o-orsellinic acid biosynthesis|positive regulation of o-orsellinic acid formation|positive regulation of o-orsellinic acid synthesis|up regulation of o-orsellinic acid anabolism|up regulation of o-orsellinic acid biosynthesis|up regulation of o-orsellinic acid biosynthetic process|up regulation of o-orsellinic acid formation|up regulation of o-orsellinic acid synthesis|up-regulation of o-orsellinic acid anabolism|up-regulation of o-orsellinic acid biosynthesis|up-regulation of o-orsellinic acid biosynthetic process|up-regulation of o-orsellinic acid formation|up-regulation of o-orsellinic acid synthesis|upregulation of o-orsellinic acid anabolism|upregulation of o-orsellinic acid biosynthesis|upregulation of o-orsellinic acid biosynthetic process|upregulation of o-orsellinic acid formation|upregulation of o-orsellinic acid synthesis http://purl.obolibrary.org/obo/GO_1900700 GO:1900703 biolink:BiologicalProcess positive regulation of orcinol biosynthetic process Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process. go.json activation of orcinol anabolism|activation of orcinol biosynthesis|activation of orcinol biosynthetic process|activation of orcinol formation|activation of orcinol synthesis|positive regulation of orcinol anabolism|positive regulation of orcinol biosynthesis|positive regulation of orcinol formation|positive regulation of orcinol synthesis|up regulation of orcinol anabolism|up regulation of orcinol biosynthesis|up regulation of orcinol biosynthetic process|up regulation of orcinol formation|up regulation of orcinol synthesis|up-regulation of orcinol anabolism|up-regulation of orcinol biosynthesis|up-regulation of orcinol biosynthetic process|up-regulation of orcinol formation|up-regulation of orcinol synthesis|upregulation of orcinol anabolism|upregulation of orcinol biosynthesis|upregulation of orcinol biosynthetic process|upregulation of orcinol formation|upregulation of orcinol synthesis http://purl.obolibrary.org/obo/GO_1900703 GO:0022600 biolink:BiologicalProcess digestive system process A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. go.json http://purl.obolibrary.org/obo/GO_0022600 goslim_generic GO:1900702 biolink:BiologicalProcess negative regulation of orcinol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process. go.json down regulation of orcinol anabolism|down regulation of orcinol biosynthesis|down regulation of orcinol biosynthetic process|down regulation of orcinol formation|down regulation of orcinol synthesis|down-regulation of orcinol anabolism|down-regulation of orcinol biosynthesis|down-regulation of orcinol biosynthetic process|down-regulation of orcinol formation|down-regulation of orcinol synthesis|downregulation of orcinol anabolism|downregulation of orcinol biosynthesis|downregulation of orcinol biosynthetic process|downregulation of orcinol formation|downregulation of orcinol synthesis|inhibition of orcinol anabolism|inhibition of orcinol biosynthesis|inhibition of orcinol biosynthetic process|inhibition of orcinol formation|inhibition of orcinol synthesis|negative regulation of orcinol anabolism|negative regulation of orcinol biosynthesis|negative regulation of orcinol formation|negative regulation of orcinol synthesis http://purl.obolibrary.org/obo/GO_1900702 GO:0046635 biolink:BiologicalProcess positive regulation of alpha-beta T cell activation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. go.json activation of alpha-beta T cell activation|positive regulation of alpha-beta T lymphocyte activation|positive regulation of alpha-beta T-cell activation|positive regulation of alpha-beta T-lymphocyte activation|stimulation of alpha-beta T cell activation|up regulation of alpha-beta T cell activation|up-regulation of alpha-beta T cell activation|upregulation of alpha-beta T cell activation http://purl.obolibrary.org/obo/GO_0046635 GO:0046634 biolink:BiologicalProcess regulation of alpha-beta T cell activation Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. go.json regulation of alpha-beta T lymphocyte activation|regulation of alpha-beta T-cell activation|regulation of alpha-beta T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0046634 GO:0046633 biolink:BiologicalProcess alpha-beta T cell proliferation The expansion of an alpha-beta T cell population by cell division. go.json alpha-beta T lymphocyte proliferation|alpha-beta T-cell proliferation|alpha-beta T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046633 GO:0046632 biolink:BiologicalProcess alpha-beta T cell differentiation The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. go.json alpha-beta T cell development|alpha-beta T lymphocyte differentiation|alpha-beta T-cell differentiation|alpha-beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0046632 GO:0046631 biolink:BiologicalProcess alpha-beta T cell activation The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. go.json alpha-beta T lymphocyte activation|alpha-beta T-cell activation|alpha-beta T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0046631 GO:0046630 biolink:BiologicalProcess gamma-delta T cell proliferation The expansion of a gamma-delta T cell population by cell division. go.json gamma-delta T lymphocyte proliferation|gamma-delta T-cell proliferation|gamma-delta T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046630 GO:0022609 biolink:BiologicalProcess multicellular organism adhesion to substrate The attachment of a multicellular organism to a surface or material. go.json http://purl.obolibrary.org/obo/GO_0022609 GO:0046639 biolink:BiologicalProcess negative regulation of alpha-beta T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. go.json down regulation of alpha-beta T cell differentiation|down-regulation of alpha-beta T cell differentiation|downregulation of alpha-beta T cell differentiation|inhibition of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell development|negative regulation of alpha-beta T lymphocyte differentiation|negative regulation of alpha-beta T-cell differentiation|negative regulation of alpha-beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0046639 GO:0046638 biolink:BiologicalProcess positive regulation of alpha-beta T cell differentiation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. go.json activation of alpha-beta T cell differentiation|positive regulation of alpha-beta T cell development|positive regulation of alpha-beta T lymphocyte differentiation|positive regulation of alpha-beta T-cell differentiation|positive regulation of alpha-beta T-lymphocyte differentiation|stimulation of alpha-beta T cell differentiation|up regulation of alpha-beta T cell differentiation|up-regulation of alpha-beta T cell differentiation|upregulation of alpha-beta T cell differentiation http://purl.obolibrary.org/obo/GO_0046638 GO:0046637 biolink:BiologicalProcess regulation of alpha-beta T cell differentiation Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. go.json regulation of alpha-beta T cell development|regulation of alpha-beta T lymphocyte differentiation|regulation of alpha-beta T-cell differentiation|regulation of alpha-beta T-lymphocyte differentiation http://purl.obolibrary.org/obo/GO_0046637 GO:0046636 biolink:BiologicalProcess negative regulation of alpha-beta T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. go.json down regulation of alpha-beta T cell activation|down-regulation of alpha-beta T cell activation|downregulation of alpha-beta T cell activation|inhibition of alpha-beta T cell activation|negative regulation of alpha-beta T lymphocyte activation|negative regulation of alpha-beta T-cell activation|negative regulation of alpha-beta T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0046636 GO:0022602 biolink:BiologicalProcess ovulation cycle process A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. go.json estrous cycle process|menstrual cycle process http://purl.obolibrary.org/obo/GO_0022602 GO:0022601 biolink:BiologicalProcess menstrual cycle phase The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur. go.json http://purl.obolibrary.org/obo/GO_0022601 gocheck_do_not_annotate GO:0022604 biolink:BiologicalProcess regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. go.json negative regulation of cell shape and cell size|positive regulation of cell shape and cell size|regulation of cell shape and cell size http://purl.obolibrary.org/obo/GO_0022604 GO:0022603 biolink:BiologicalProcess regulation of anatomical structure morphogenesis Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. go.json regulation of morphogenesis http://purl.obolibrary.org/obo/GO_0022603 GO:1900709 biolink:BiologicalProcess positive regulation of tensidol A biosynthetic process Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process. go.json activation of tensidol A anabolism|activation of tensidol A biosynthesis|activation of tensidol A biosynthetic process|activation of tensidol A formation|activation of tensidol A synthesis|positive regulation of tensidol A anabolism|positive regulation of tensidol A biosynthesis|positive regulation of tensidol A formation|positive regulation of tensidol A synthesis|up regulation of tensidol A anabolism|up regulation of tensidol A biosynthesis|up regulation of tensidol A biosynthetic process|up regulation of tensidol A formation|up regulation of tensidol A synthesis|up-regulation of tensidol A anabolism|up-regulation of tensidol A biosynthesis|up-regulation of tensidol A biosynthetic process|up-regulation of tensidol A formation|up-regulation of tensidol A synthesis|upregulation of tensidol A anabolism|upregulation of tensidol A biosynthesis|upregulation of tensidol A biosynthetic process|upregulation of tensidol A formation|upregulation of tensidol A synthesis http://purl.obolibrary.org/obo/GO_1900709 GO:0022606 biolink:BiologicalProcess establishment of proximal/distal cell polarity The specification and formation of the polarity of a cell along its proximal/distal axis. go.json http://purl.obolibrary.org/obo/GO_0022606 GO:1900708 biolink:BiologicalProcess negative regulation of tensidol A biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of tensidol A biosynthetic process. go.json down regulation of tensidol A anabolism|down regulation of tensidol A biosynthesis|down regulation of tensidol A biosynthetic process|down regulation of tensidol A formation|down regulation of tensidol A synthesis|down-regulation of tensidol A anabolism|down-regulation of tensidol A biosynthesis|down-regulation of tensidol A biosynthetic process|down-regulation of tensidol A formation|down-regulation of tensidol A synthesis|downregulation of tensidol A anabolism|downregulation of tensidol A biosynthesis|downregulation of tensidol A biosynthetic process|downregulation of tensidol A formation|downregulation of tensidol A synthesis|inhibition of tensidol A anabolism|inhibition of tensidol A biosynthesis|inhibition of tensidol A biosynthetic process|inhibition of tensidol A formation|inhibition of tensidol A synthesis|negative regulation of tensidol A anabolism|negative regulation of tensidol A biosynthesis|negative regulation of tensidol A formation|negative regulation of tensidol A synthesis http://purl.obolibrary.org/obo/GO_1900708 GO:0022605 biolink:BiologicalProcess mammalian oogenesis stage A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell. go.json mammalian oogenesis process http://purl.obolibrary.org/obo/GO_0022605 GO:0022608 biolink:BiologicalProcess multicellular organism adhesion The attachment of a multicellular organism to a substrate or other organism. go.json http://purl.obolibrary.org/obo/GO_0022608 GO:0022607 biolink:BiologicalProcess cellular component assembly The aggregation, arrangement and bonding together of a cellular component. go.json cell structure assembly|cellular component assembly at cellular level http://purl.obolibrary.org/obo/GO_0022607 goslim_chembl|goslim_pir GO:1900716 biolink:BiologicalProcess regulation of violaceol II biosynthetic process Any process that modulates the frequency, rate or extent of violaceol II biosynthetic process. go.json regulation of violaceol II anabolism|regulation of violaceol II biosynthesis|regulation of violaceol II formation|regulation of violaceol II synthesis http://purl.obolibrary.org/obo/GO_1900716 GO:1900715 biolink:BiologicalProcess positive regulation of violaceol I biosynthetic process Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process. go.json activation of violaceol I anabolism|activation of violaceol I biosynthesis|activation of violaceol I biosynthetic process|activation of violaceol I formation|activation of violaceol I synthesis|positive regulation of violaceol I anabolism|positive regulation of violaceol I biosynthesis|positive regulation of violaceol I formation|positive regulation of violaceol I synthesis|up regulation of violaceol I anabolism|up regulation of violaceol I biosynthesis|up regulation of violaceol I biosynthetic process|up regulation of violaceol I formation|up regulation of violaceol I synthesis|up-regulation of violaceol I anabolism|up-regulation of violaceol I biosynthesis|up-regulation of violaceol I biosynthetic process|up-regulation of violaceol I formation|up-regulation of violaceol I synthesis|upregulation of violaceol I anabolism|upregulation of violaceol I biosynthesis|upregulation of violaceol I biosynthetic process|upregulation of violaceol I formation|upregulation of violaceol I synthesis http://purl.obolibrary.org/obo/GO_1900715 GO:1900718 biolink:BiologicalProcess positive regulation of violaceol II biosynthetic process Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process. go.json activation of violaceol II anabolism|activation of violaceol II biosynthesis|activation of violaceol II biosynthetic process|activation of violaceol II formation|activation of violaceol II synthesis|positive regulation of violaceol II anabolism|positive regulation of violaceol II biosynthesis|positive regulation of violaceol II formation|positive regulation of violaceol II synthesis|up regulation of violaceol II anabolism|up regulation of violaceol II biosynthesis|up regulation of violaceol II biosynthetic process|up regulation of violaceol II formation|up regulation of violaceol II synthesis|up-regulation of violaceol II anabolism|up-regulation of violaceol II biosynthesis|up-regulation of violaceol II biosynthetic process|up-regulation of violaceol II formation|up-regulation of violaceol II synthesis|upregulation of violaceol II anabolism|upregulation of violaceol II biosynthesis|upregulation of violaceol II biosynthetic process|upregulation of violaceol II formation|upregulation of violaceol II synthesis http://purl.obolibrary.org/obo/GO_1900718 GO:1900717 biolink:BiologicalProcess negative regulation of violaceol II biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process. go.json down regulation of violaceol II anabolism|down regulation of violaceol II biosynthesis|down regulation of violaceol II biosynthetic process|down regulation of violaceol II formation|down regulation of violaceol II synthesis|down-regulation of violaceol II anabolism|down-regulation of violaceol II biosynthesis|down-regulation of violaceol II biosynthetic process|down-regulation of violaceol II formation|down-regulation of violaceol II synthesis|downregulation of violaceol II anabolism|downregulation of violaceol II biosynthesis|downregulation of violaceol II biosynthetic process|downregulation of violaceol II formation|downregulation of violaceol II synthesis|inhibition of violaceol II anabolism|inhibition of violaceol II biosynthesis|inhibition of violaceol II biosynthetic process|inhibition of violaceol II formation|inhibition of violaceol II synthesis|negative regulation of violaceol II anabolism|negative regulation of violaceol II biosynthesis|negative regulation of violaceol II formation|negative regulation of violaceol II synthesis http://purl.obolibrary.org/obo/GO_1900717 GO:1900712 biolink:BiologicalProcess positive regulation of tensidol B biosynthetic process Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process. go.json activation of tensidol B anabolism|activation of tensidol B biosynthesis|activation of tensidol B biosynthetic process|activation of tensidol B formation|activation of tensidol B synthesis|positive regulation of tensidol B anabolism|positive regulation of tensidol B biosynthesis|positive regulation of tensidol B formation|positive regulation of tensidol B synthesis|up regulation of tensidol B anabolism|up regulation of tensidol B biosynthesis|up regulation of tensidol B biosynthetic process|up regulation of tensidol B formation|up regulation of tensidol B synthesis|up-regulation of tensidol B anabolism|up-regulation of tensidol B biosynthesis|up-regulation of tensidol B biosynthetic process|up-regulation of tensidol B formation|up-regulation of tensidol B synthesis|upregulation of tensidol B anabolism|upregulation of tensidol B biosynthesis|upregulation of tensidol B biosynthetic process|upregulation of tensidol B formation|upregulation of tensidol B synthesis http://purl.obolibrary.org/obo/GO_1900712 GO:1900711 biolink:BiologicalProcess negative regulation of tensidol B biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process. go.json down regulation of tensidol B anabolism|down regulation of tensidol B biosynthesis|down regulation of tensidol B biosynthetic process|down regulation of tensidol B formation|down regulation of tensidol B synthesis|down-regulation of tensidol B anabolism|down-regulation of tensidol B biosynthesis|down-regulation of tensidol B biosynthetic process|down-regulation of tensidol B formation|down-regulation of tensidol B synthesis|downregulation of tensidol B anabolism|downregulation of tensidol B biosynthesis|downregulation of tensidol B biosynthetic process|downregulation of tensidol B formation|downregulation of tensidol B synthesis|inhibition of tensidol B anabolism|inhibition of tensidol B biosynthesis|inhibition of tensidol B biosynthetic process|inhibition of tensidol B formation|inhibition of tensidol B synthesis|negative regulation of tensidol B anabolism|negative regulation of tensidol B biosynthesis|negative regulation of tensidol B formation|negative regulation of tensidol B synthesis http://purl.obolibrary.org/obo/GO_1900711 GO:1900714 biolink:BiologicalProcess negative regulation of violaceol I biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process. go.json down regulation of violaceol I anabolism|down regulation of violaceol I biosynthesis|down regulation of violaceol I biosynthetic process|down regulation of violaceol I formation|down regulation of violaceol I synthesis|down-regulation of violaceol I anabolism|down-regulation of violaceol I biosynthesis|down-regulation of violaceol I biosynthetic process|down-regulation of violaceol I formation|down-regulation of violaceol I synthesis|downregulation of violaceol I anabolism|downregulation of violaceol I biosynthesis|downregulation of violaceol I biosynthetic process|downregulation of violaceol I formation|downregulation of violaceol I synthesis|inhibition of violaceol I anabolism|inhibition of violaceol I biosynthesis|inhibition of violaceol I biosynthetic process|inhibition of violaceol I formation|inhibition of violaceol I synthesis|negative regulation of violaceol I anabolism|negative regulation of violaceol I biosynthesis|negative regulation of violaceol I formation|negative regulation of violaceol I synthesis http://purl.obolibrary.org/obo/GO_1900714 GO:1900713 biolink:BiologicalProcess regulation of violaceol I biosynthetic process Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process. go.json regulation of violaceol I anabolism|regulation of violaceol I biosynthesis|regulation of violaceol I formation|regulation of violaceol I synthesis http://purl.obolibrary.org/obo/GO_1900713 OIO:hasSynonymType biolink:OntologyClass has_synonym_type go.json http://www.geneontology.org/formats/oboInOwl#hasSynonymType GO:0046646 biolink:BiologicalProcess regulation of gamma-delta T cell proliferation Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation. go.json regulation of gamma-delta T lymphocyte proliferation|regulation of gamma-delta T-cell proliferation|regulation of gamma-delta T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046646 GO:0046645 biolink:BiologicalProcess positive regulation of gamma-delta T cell activation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation. go.json activation of gamma-delta T cell activation|positive regulation of gamma-delta T lymphocyte activation|positive regulation of gamma-delta T-cell activation|positive regulation of gamma-delta T-lymphocyte activation|stimulation of gamma-delta T cell activation|up regulation of gamma-delta T cell activation|up-regulation of gamma-delta T cell activation|upregulation of gamma-delta T cell activation http://purl.obolibrary.org/obo/GO_0046645 GO:1900710 biolink:BiologicalProcess regulation of tensidol B biosynthetic process Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process. go.json regulation of tensidol B anabolism|regulation of tensidol B biosynthesis|regulation of tensidol B formation|regulation of tensidol B synthesis http://purl.obolibrary.org/obo/GO_1900710 GO:0046644 biolink:BiologicalProcess negative regulation of gamma-delta T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation. go.json down regulation of gamma-delta T cell activation|down-regulation of gamma-delta T cell activation|downregulation of gamma-delta T cell activation|inhibition of gamma-delta T cell activation|negative regulation of gamma-delta T lymphocyte activation|negative regulation of gamma-delta T-cell activation|negative regulation of gamma-delta T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0046644 GO:0046643 biolink:BiologicalProcess regulation of gamma-delta T cell activation Any process that modulates the frequency, rate or extent of gamma-delta T cell activation. go.json regulation of gamma-delta T lymphocyte activation|regulation of gamma-delta T-cell activation|regulation of gamma-delta T-lymphocyte activation http://purl.obolibrary.org/obo/GO_0046643 GO:0046642 biolink:BiologicalProcess negative regulation of alpha-beta T cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation. go.json down regulation of alpha-beta T cell proliferation|down-regulation of alpha-beta T cell proliferation|downregulation of alpha-beta T cell proliferation|inhibition of alpha-beta T cell proliferation|negative regulation of alpha-beta T lymphocyte proliferation|negative regulation of alpha-beta T-cell proliferation|negative regulation of alpha-beta T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046642 GO:0046641 biolink:BiologicalProcess positive regulation of alpha-beta T cell proliferation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. go.json activation of alpha-beta T cell proliferation|positive regulation of alpha-beta T lymphocyte proliferation|positive regulation of alpha-beta T-cell proliferation|positive regulation of alpha-beta T-lymphocyte proliferation|stimulation of alpha-beta T cell proliferation|up regulation of alpha-beta T cell proliferation|up-regulation of alpha-beta T cell proliferation|upregulation of alpha-beta T cell proliferation http://purl.obolibrary.org/obo/GO_0046641 GO:0046640 biolink:BiologicalProcess regulation of alpha-beta T cell proliferation Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. go.json regulation of alpha-beta T lymphocyte proliferation|regulation of alpha-beta T-cell proliferation|regulation of alpha-beta T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046640 GO:0071609 biolink:BiologicalProcess chemokine (C-C motif) ligand 5 production The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL5 production|RANTES production|Regulated upon Activation, Normal T-cell Expressed, and Secreted production http://purl.obolibrary.org/obo/GO_0071609 gocheck_do_not_annotate GO:0071608 biolink:BiologicalProcess macrophage inflammatory protein-1 alpha production The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL3 production|MIP-1a production|chemokine (C-C motif) ligand 3 production|macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071608 gocheck_do_not_annotate GO:0071607 biolink:BiologicalProcess macrophage inflammatory protein-1 gamma production The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL9 production|MIP-1g production|chemokine (C-C motif) ligand 9 production http://purl.obolibrary.org/obo/GO_0071607 gocheck_do_not_annotate GO:0071606 biolink:BiologicalProcess chemokine (C-C motif) ligand 4 production The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL4 production|MIP-1b production|macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071606 gocheck_do_not_annotate GO:0071605 biolink:BiologicalProcess monocyte chemotactic protein-1 production The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL2 production|MCP-1 production http://purl.obolibrary.org/obo/GO_0071605 gocheck_do_not_annotate GO:0046649 biolink:BiologicalProcess lymphocyte activation A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. go.json http://purl.obolibrary.org/obo/GO_0046649 GO:0071604 biolink:BiologicalProcess transforming growth factor beta production The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3. go.json TGF-B production|TGF-beta production|TGFb production|TGFbeta production|transforming growth factor-beta production|transforming growth factor-beta secretion http://purl.obolibrary.org/obo/GO_0071604 GO:0046648 biolink:BiologicalProcess positive regulation of gamma-delta T cell proliferation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation. go.json activation of gamma-delta T cell proliferation|positive regulation of gamma-delta T lymphocyte proliferation|positive regulation of gamma-delta T-cell proliferation|positive regulation of gamma-delta T-lymphocyte proliferation|stimulation of gamma-delta T cell proliferation|up regulation of gamma-delta T cell proliferation|up-regulation of gamma-delta T cell proliferation|upregulation of gamma-delta T cell proliferation http://purl.obolibrary.org/obo/GO_0046648 GO:0071603 biolink:BiologicalProcess endothelial cell-cell adhesion The attachment of an endothelial cell to another endothelial cell via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0071603 GO:0046647 biolink:BiologicalProcess negative regulation of gamma-delta T cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation. go.json down regulation of gamma-delta T cell proliferation|down-regulation of gamma-delta T cell proliferation|downregulation of gamma-delta T cell proliferation|inhibition of gamma-delta T cell proliferation|negative regulation of gamma-delta T lymphocyte proliferation|negative regulation of gamma-delta T-cell proliferation|negative regulation of gamma-delta T-lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0046647 GO:0071602 biolink:BiologicalProcess phytosphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol. go.json phytosphingosine anabolism|phytosphingosine biosynthesis|phytosphingosine formation|phytosphingosine synthesis http://purl.obolibrary.org/obo/GO_0071602 GO:0071601 biolink:CellularComponent sphere organelle A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins. go.json http://purl.obolibrary.org/obo/GO_0071601 GO:0071600 biolink:BiologicalProcess otic vesicle morphogenesis The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. go.json http://purl.obolibrary.org/obo/GO_0071600 GO:1900719 biolink:BiologicalProcess regulation of uterine smooth muscle relaxation Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation. go.json regulation of smooth muscle relaxation of the uterus http://purl.obolibrary.org/obo/GO_1900719 GO:1900727 biolink:BiologicalProcess osmoregulated periplasmic glucan biosynthetic process The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan. go.json osmoregulated periplasmic glucan anabolism|osmoregulated periplasmic glucan biosynthesis|osmoregulated periplasmic glucan formation|osmoregulated periplasmic glucan synthesis http://purl.obolibrary.org/obo/GO_1900727 GO:1900726 biolink:BiologicalProcess osmoregulated periplasmic glucan catabolic process The chemical reactions and pathways resulting in the breakdown of osmoregulated periplasmic glucan. go.json osmoregulated periplasmic glucan breakdown|osmoregulated periplasmic glucan catabolism|osmoregulated periplasmic glucan degradation http://purl.obolibrary.org/obo/GO_1900726 GO:1900729 biolink:BiologicalProcess regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway. go.json regulation of inhibition of adenylate cyclase activity by opioid receptor|regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway|regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway|regulation of opioid receptor-mediated adenylate cyclase inhibition http://purl.obolibrary.org/obo/GO_1900729 GO:1900728 biolink:BiologicalProcess cardiac neural crest cell delamination involved in outflow tract morphogenesis Any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis. go.json http://purl.obolibrary.org/obo/GO_1900728 GO:1900723 biolink:BiologicalProcess negative regulation of protein adenylylation Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation. go.json down regulation of protein AMPylation|down regulation of protein adenylation|down regulation of protein adenylylation|down regulation of protein amino acid adenylylation|down-regulation of protein AMPylation|down-regulation of protein adenylation|down-regulation of protein adenylylation|down-regulation of protein amino acid adenylylation|downregulation of protein AMPylation|downregulation of protein adenylation|downregulation of protein adenylylation|downregulation of protein amino acid adenylylation|inhibition of protein AMPylation|inhibition of protein adenylation|inhibition of protein adenylylation|inhibition of protein amino acid adenylylation|negative regulation of protein AMPylation|negative regulation of protein adenylation|negative regulation of protein amino acid adenylylation http://purl.obolibrary.org/obo/GO_1900723 GO:1900722 biolink:BiologicalProcess regulation of protein adenylylation Any process that modulates the frequency, rate or extent of protein adenylylation. go.json regulation of protein AMPylation|regulation of protein adenylation|regulation of protein amino acid adenylylation http://purl.obolibrary.org/obo/GO_1900722 GO:1900725 biolink:BiologicalProcess osmoregulated periplasmic glucan metabolic process The chemical reactions and pathways involving osmoregulated periplasmic glucan. go.json osmoregulated periplasmic glucan metabolism http://purl.obolibrary.org/obo/GO_1900725 GO:1900724 biolink:BiologicalProcess positive regulation of protein adenylylation Any process that activates or increases the frequency, rate or extent of protein adenylylation. go.json activation of protein AMPylation|activation of protein adenylation|activation of protein adenylylation|activation of protein amino acid adenylylation|positive regulation of protein AMPylation|positive regulation of protein adenylation|positive regulation of protein amino acid adenylylation|up regulation of protein AMPylation|up regulation of protein adenylation|up regulation of protein adenylylation|up regulation of protein amino acid adenylylation|up-regulation of protein AMPylation|up-regulation of protein adenylation|up-regulation of protein adenylylation|up-regulation of protein amino acid adenylylation|upregulation of protein AMPylation|upregulation of protein adenylation|upregulation of protein adenylylation|upregulation of protein amino acid adenylylation http://purl.obolibrary.org/obo/GO_1900724 GO:0046657 biolink:BiologicalProcess folic acid catabolic process The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid. go.json folate catabolic process|folate catabolism|folic acid breakdown|folic acid catabolism|folic acid degradation|vitamin B9 catabolic process|vitamin B9 catabolism|vitamin M catabolic process|vitamin M catabolism http://purl.obolibrary.org/obo/GO_0046657 GO:0046656 biolink:BiologicalProcess folic acid biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. MetaCyc:FOLSYN-PWY|Wikipedia:Folic_acid go.json folate biosynthesis|folate biosynthetic process|folic acid anabolism|folic acid biosynthesis|folic acid formation|folic acid synthesis|vitamin B9 biosynthesis|vitamin B9 biosynthetic process|vitamin M biosynthesis|vitamin M biosynthetic process http://purl.obolibrary.org/obo/GO_0046656 GO:1900721 biolink:BiologicalProcess positive regulation of uterine smooth muscle relaxation Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation. go.json activation of smooth muscle relaxation of the uterus|activation of uterine smooth muscle relaxation|positive regulation of smooth muscle relaxation of the uterus|up regulation of smooth muscle relaxation of the uterus|up regulation of uterine smooth muscle relaxation|up-regulation of smooth muscle relaxation of the uterus|up-regulation of uterine smooth muscle relaxation|upregulation of smooth muscle relaxation of the uterus|upregulation of uterine smooth muscle relaxation http://purl.obolibrary.org/obo/GO_1900721 GO:0046655 biolink:BiologicalProcess folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. go.json folate metabolic process|folate metabolism|folic acid metabolism|vitamin B9 metabolic process|vitamin B9 metabolism|vitamin M metabolic process|vitamin M metabolism http://purl.obolibrary.org/obo/GO_0046655 GO:0046654 biolink:BiologicalProcess tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. MetaCyc:FOLSYN-PWY go.json tetrahydrofolate anabolism|tetrahydrofolate biosynthesis|tetrahydrofolate formation|tetrahydrofolate synthesis http://purl.obolibrary.org/obo/GO_0046654 GO:1900720 biolink:BiologicalProcess negative regulation of uterine smooth muscle relaxation Any process that stops, prevents or reduces the frequency, rate or extent of uterine smooth muscle relaxation. go.json down regulation of smooth muscle relaxation of the uterus|down regulation of uterine smooth muscle relaxation|down-regulation of smooth muscle relaxation of the uterus|down-regulation of uterine smooth muscle relaxation|downregulation of smooth muscle relaxation of the uterus|downregulation of uterine smooth muscle relaxation|inhibition of smooth muscle relaxation of the uterus|inhibition of uterine smooth muscle relaxation|negative regulation of smooth muscle relaxation of the uterus http://purl.obolibrary.org/obo/GO_1900720 GO:0046653 biolink:BiologicalProcess tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. go.json tetrahydrofolate metabolism http://purl.obolibrary.org/obo/GO_0046653 GO:0046652 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046652 GO:0046651 biolink:BiologicalProcess lymphocyte proliferation The expansion of a lymphocyte population by cell division. go.json http://purl.obolibrary.org/obo/GO_0046651 GO:0046650 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046650 GO:0046659 biolink:MolecularActivity digestive hormone activity The action characteristic of a hormone that takes part in the digestion process. go.json secretin http://purl.obolibrary.org/obo/GO_0046659 GO:0046658 biolink:CellularComponent obsolete anchored component of plasma membrane OBSOLETE. The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. go.json anchored to plasma membrane|plasma membrane, GPI-anchored True http://purl.obolibrary.org/obo/GO_0046658 GO:1900738 biolink:BiologicalProcess positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. go.json activation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|activation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|activation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|activation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|activation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|activation of PLC-activating GPCR signaling pathway|activation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of phospholipase C-activating G-protein coupled receptor signaling pathway|activation of phospholipase C-activating dopamine receptor signaling pathway|positive regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|positive regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|positive regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|positive regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|positive regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|positive regulation of PLC-activating GPCR signaling pathway|positive regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of phospholipase C-activating dopamine receptor signaling pathway|up regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|up regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|up regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|up regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|up regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|up regulation of PLC-activating GPCR signaling pathway|up regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|up regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|up regulation of phospholipase C-activating dopamine receptor signaling pathway|up-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|up-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|up-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|up-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|up-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|up-regulation of PLC-activating GPCR signaling pathway|up-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|up-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|up-regulation of phospholipase C-activating dopamine receptor signaling pathway|upregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|upregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|upregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|upregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|upregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|upregulation of PLC-activating GPCR signaling pathway|upregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|upregulation of phospholipase C-activating G-protein coupled receptor signaling pathway|upregulation of phospholipase C-activating dopamine receptor signaling pathway http://purl.obolibrary.org/obo/GO_1900738 GO:0046660 biolink:BiologicalProcess female sex differentiation The establishment of the sex of a female organism by physical differentiation. go.json http://purl.obolibrary.org/obo/GO_0046660 GO:1900737 biolink:BiologicalProcess negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. go.json down regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|down regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|down regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|down regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|down regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|down regulation of PLC-activating GPCR signaling pathway|down regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|down regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|down regulation of phospholipase C-activating dopamine receptor signaling pathway|down-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|down-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|down-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|down-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|down-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|down-regulation of PLC-activating GPCR signaling pathway|down-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|down-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|down-regulation of phospholipase C-activating dopamine receptor signaling pathway|downregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|downregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|downregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|downregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|downregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|downregulation of PLC-activating GPCR signaling pathway|downregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|downregulation of phospholipase C-activating G-protein coupled receptor signaling pathway|downregulation of phospholipase C-activating dopamine receptor signaling pathway|inhibition of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|inhibition of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|inhibition of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|inhibition of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|inhibition of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|inhibition of PLC-activating GPCR signaling pathway|inhibition of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inhibition of phospholipase C-activating G-protein coupled receptor signaling pathway|inhibition of phospholipase C-activating dopamine receptor signaling pathway|negative regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|negative regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|negative regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|negative regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|negative regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|negative regulation of PLC-activating GPCR signaling pathway|negative regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|negative regulation of phospholipase C-activating dopamine receptor signaling pathway http://purl.obolibrary.org/obo/GO_1900737 GO:1900739 biolink:BiologicalProcess regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. go.json regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|regulation of protein insertion into mitochondrial membrane during induction of apoptosis|regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|regulation of protein insertion into mitochondrion membrane during induction of apoptosis http://purl.obolibrary.org/obo/GO_1900739 GO:1900734 biolink:BiologicalProcess positive regulation of polyketide biosynthetic process Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process. go.json activation of polyketide anabolism|activation of polyketide biosynthesis|activation of polyketide biosynthetic process|activation of polyketide formation|activation of polyketide synthesis|positive regulation of polyketide anabolism|positive regulation of polyketide biosynthesis|positive regulation of polyketide formation|positive regulation of polyketide synthesis|up regulation of polyketide anabolism|up regulation of polyketide biosynthesis|up regulation of polyketide biosynthetic process|up regulation of polyketide formation|up regulation of polyketide synthesis|up-regulation of polyketide anabolism|up-regulation of polyketide biosynthesis|up-regulation of polyketide biosynthetic process|up-regulation of polyketide formation|up-regulation of polyketide synthesis|upregulation of polyketide anabolism|upregulation of polyketide biosynthesis|upregulation of polyketide biosynthetic process|upregulation of polyketide formation|upregulation of polyketide synthesis http://purl.obolibrary.org/obo/GO_1900734 GO:1900733 biolink:BiologicalProcess negative regulation of polyketide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process. go.json down regulation of polyketide anabolism|down regulation of polyketide biosynthesis|down regulation of polyketide biosynthetic process|down regulation of polyketide formation|down regulation of polyketide synthesis|down-regulation of polyketide anabolism|down-regulation of polyketide biosynthesis|down-regulation of polyketide biosynthetic process|down-regulation of polyketide formation|down-regulation of polyketide synthesis|downregulation of polyketide anabolism|downregulation of polyketide biosynthesis|downregulation of polyketide biosynthetic process|downregulation of polyketide formation|downregulation of polyketide synthesis|inhibition of polyketide anabolism|inhibition of polyketide biosynthesis|inhibition of polyketide biosynthetic process|inhibition of polyketide formation|inhibition of polyketide synthesis|negative regulation of polyketide anabolism|negative regulation of polyketide biosynthesis|negative regulation of polyketide formation|negative regulation of polyketide synthesis http://purl.obolibrary.org/obo/GO_1900733 GO:1900736 biolink:BiologicalProcess regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. go.json regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger|regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|regulation of PLC-activating GPCR signaling pathway|regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|regulation of phospholipase C-activating dopamine receptor signaling pathway http://purl.obolibrary.org/obo/GO_1900736 GO:1900735 biolink:BiologicalProcess positive regulation of flocculation Any process that activates or increases the frequency, rate or extent of flocculation. go.json activation of flocculation|activation of flocculation via cell wall protein-carbohydrate interaction|positive regulation of flocculation via cell wall protein-carbohydrate interaction|up regulation of flocculation|up regulation of flocculation via cell wall protein-carbohydrate interaction|up-regulation of flocculation|up-regulation of flocculation via cell wall protein-carbohydrate interaction|upregulation of flocculation|upregulation of flocculation via cell wall protein-carbohydrate interaction http://purl.obolibrary.org/obo/GO_1900735 GO:1900730 biolink:BiologicalProcess negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway. go.json down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway|down-regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway|downregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway|inhibition of adenylate cyclase-inhibiting opioid receptor signaling pathway|inhibition of opioid receptor-mediated adenylate cyclase inhibition|negative regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway|negative regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway http://purl.obolibrary.org/obo/GO_1900730 GO:0046668 biolink:BiologicalProcess regulation of retinal cell programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. go.json regulation of retinal programmed cell death http://purl.obolibrary.org/obo/GO_0046668 GO:0046667 biolink:BiologicalProcess compound eye retinal cell programmed cell death Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. go.json http://purl.obolibrary.org/obo/GO_0046667 GO:1900732 biolink:BiologicalProcess regulation of polyketide biosynthetic process Any process that modulates the frequency, rate or extent of polyketide biosynthetic process. go.json regulation of polyketide anabolism|regulation of polyketide biosynthesis|regulation of polyketide formation|regulation of polyketide synthesis http://purl.obolibrary.org/obo/GO_1900732 GO:0046666 biolink:BiologicalProcess retinal cell programmed cell death Programmed cell death that occurs in the developing retina. go.json programmed cell death, retina cells|programmed cell death, retinal cells|retina cell programmed cell death|retina programmed cell death|retinal programmed cell death http://purl.obolibrary.org/obo/GO_0046666 GO:1900731 biolink:BiologicalProcess positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway. go.json activation of adenylate cyclase-inhibiting opioid receptor signaling pathway|activation of opioid receptor-mediated adenylate cyclase inhibition|up regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway|upregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway http://purl.obolibrary.org/obo/GO_1900731 GO:0046665 biolink:BiologicalProcess amnioserosa maintenance Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. go.json http://purl.obolibrary.org/obo/GO_0046665 GO:0046664 biolink:BiologicalProcess dorsal closure, amnioserosa morphology change The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo. go.json http://purl.obolibrary.org/obo/GO_0046664 GO:0046663 biolink:BiologicalProcess dorsal closure, leading edge cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure. go.json http://purl.obolibrary.org/obo/GO_0046663 GO:0046662 biolink:BiologicalProcess regulation of egg-laying behavior Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium. go.json regulation of oviposition|regulation of post-mating oviposition http://purl.obolibrary.org/obo/GO_0046662 GO:0046661 biolink:BiologicalProcess male sex differentiation The establishment of the sex of a male organism by physical differentiation. go.json http://purl.obolibrary.org/obo/GO_0046661 GO:0071629 biolink:BiologicalProcess cytoplasm protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation. go.json cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism|cytoplasm-associated proteasomal ubiquitin-dependent protein degradation|ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome http://purl.obolibrary.org/obo/GO_0071629 GO:0071628 biolink:CellularComponent obsolete intrinsic component of fungal-type vacuolar membrane OBSOLETE. The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. go.json True http://purl.obolibrary.org/obo/GO_0071628 GO:0071627 biolink:CellularComponent obsolete integral component of fungal-type vacuolar membrane OBSOLETE. The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. go.json integral to fungal-type vacuolar membrane True http://purl.obolibrary.org/obo/GO_0071627 GO:0071626 biolink:BiologicalProcess mastication The process of biting and mashing food with the teeth prior to swallowing. go.json chewing http://purl.obolibrary.org/obo/GO_0071626 GO:0071625 biolink:BiologicalProcess vocalization behavior The behavior in which an organism produces sounds by a mechanism involving its respiratory system. go.json vocalisation behaviour http://purl.obolibrary.org/obo/GO_0071625 GO:0046669 biolink:BiologicalProcess regulation of compound eye retinal cell programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. go.json regulation of retinal cell programmed cell death http://purl.obolibrary.org/obo/GO_0046669 GO:0071624 biolink:BiologicalProcess positive regulation of granulocyte chemotaxis Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0071624 GO:0071623 biolink:BiologicalProcess negative regulation of granulocyte chemotaxis Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0071623 GO:0071622 biolink:BiologicalProcess regulation of granulocyte chemotaxis Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0071622 GO:0071621 biolink:BiologicalProcess granulocyte chemotaxis The movement of a granulocyte in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0071621 GO:0071620 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain serine 5 residues OBSOLETE. The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans). go.json True http://purl.obolibrary.org/obo/GO_0071620 GO:0046671 biolink:BiologicalProcess negative regulation of retinal cell programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. go.json down regulation of retinal programmed cell death|down-regulation of retinal programmed cell death|downregulation of retinal programmed cell death|inhibition of retinal programmed cell death|negative regulation of retinal programmed cell death http://purl.obolibrary.org/obo/GO_0046671 GO:1900749 biolink:BiologicalProcess (R)-carnitine transport The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json (-)-Carnitine transport|(-)-L-Carnitine transport|(3R)-3-hydroxy-4-(trimethylammonio)butanoate transport|C7H15NO3 transport|Carnicor transport|Carnitene transport|Carnitine transport|Carnitor transport|L-Carnitine transport|Levocarnitine transport|Vitamin BT transport http://purl.obolibrary.org/obo/GO_1900749 GO:1900748 biolink:BiologicalProcess positive regulation of vascular endothelial growth factor signaling pathway Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway. go.json activation of VEGF signaling|activation of VEGF-activated signaling pathway|activation of vascular endothelial growth factor signaling pathway|activation of vascular endothelial growth factor signalling pathway|positive regulation of VEGF signaling|positive regulation of VEGF-activated signaling pathway|positive regulation of vascular endothelial growth factor signalling pathway|up regulation of VEGF signaling|up regulation of VEGF-activated signaling pathway|up regulation of vascular endothelial growth factor signaling pathway|up regulation of vascular endothelial growth factor signalling pathway|up-regulation of VEGF signaling|up-regulation of VEGF-activated signaling pathway|up-regulation of vascular endothelial growth factor signaling pathway|up-regulation of vascular endothelial growth factor signalling pathway|upregulation of VEGF signaling|upregulation of VEGF-activated signaling pathway|upregulation of vascular endothelial growth factor signaling pathway|upregulation of vascular endothelial growth factor signalling pathway http://purl.obolibrary.org/obo/GO_1900748 GO:0046670 biolink:BiologicalProcess positive regulation of retinal cell programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. go.json activation of retinal programmed cell death|positive regulation of retinal programmed cell death|stimulation of retinal programmed cell death|up regulation of retinal programmed cell death|up-regulation of retinal programmed cell death|upregulation of retinal programmed cell death http://purl.obolibrary.org/obo/GO_0046670 GO:1900745 biolink:BiologicalProcess positive regulation of p38MAPK cascade Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. go.json activation of p38 MAPK cascade|activation of p38 cascade|activation of p38MAPK cascade|positive regulation of p38 MAPK cascade|positive regulation of p38 cascade|up regulation of p38 MAPK cascade|up regulation of p38 cascade|up regulation of p38MAPK cascade|up-regulation of p38 MAPK cascade|up-regulation of p38 cascade|up-regulation of p38MAPK cascade|upregulation of p38 MAPK cascade|upregulation of p38 cascade|upregulation of p38MAPK cascade http://purl.obolibrary.org/obo/GO_1900745 GO:1900744 biolink:BiologicalProcess regulation of p38MAPK cascade Any process that modulates the frequency, rate or extent of p38MAPK cascade. go.json regulation of p38 MAPK cascade|regulation of p38 cascade http://purl.obolibrary.org/obo/GO_1900744 GO:1900747 biolink:BiologicalProcess negative regulation of vascular endothelial growth factor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway. go.json down regulation of VEGF signaling|down regulation of VEGF-activated signaling pathway|down regulation of vascular endothelial growth factor signaling pathway|down regulation of vascular endothelial growth factor signalling pathway|down-regulation of VEGF signaling|down-regulation of VEGF-activated signaling pathway|down-regulation of vascular endothelial growth factor signaling pathway|down-regulation of vascular endothelial growth factor signalling pathway|downregulation of VEGF signaling|downregulation of VEGF-activated signaling pathway|downregulation of vascular endothelial growth factor signaling pathway|downregulation of vascular endothelial growth factor signalling pathway|inhibition of VEGF signaling|inhibition of VEGF-activated signaling pathway|inhibition of vascular endothelial growth factor signaling pathway|inhibition of vascular endothelial growth factor signalling pathway|negative regulation of VEGF signaling|negative regulation of VEGF-activated signaling pathway|negative regulation of vascular endothelial growth factor signalling pathway http://purl.obolibrary.org/obo/GO_1900747 GO:1900746 biolink:BiologicalProcess regulation of vascular endothelial growth factor signaling pathway Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway. go.json regulation of VEGF signaling|regulation of VEGF-activated signaling pathway|regulation of vascular endothelial growth factor signalling pathway http://purl.obolibrary.org/obo/GO_1900746 GO:1900741 biolink:BiologicalProcess regulation of filamentous growth of a population of unicellular organisms in response to pH Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH. go.json http://purl.obolibrary.org/obo/GO_1900741 GO:0046679 biolink:BiologicalProcess response to streptomycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. go.json streptomycin susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046679 GO:1900740 biolink:BiologicalProcess positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. go.json activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|activation of protein insertion into mitochondrial membrane during induction of apoptosis|activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|activation of protein insertion into mitochondrial membrane involved in induction of apoptosis|activation of protein insertion into mitochondrion membrane during induction of apoptosis|positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis|up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|up regulation of protein insertion into mitochondrial membrane during induction of apoptosis|up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|up regulation of protein insertion into mitochondrion membrane during induction of apoptosis|up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis|up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis|upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|upregulation of protein insertion into mitochondrial membrane during induction of apoptosis|upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|upregulation of protein insertion into mitochondrion membrane during induction of apoptosis http://purl.obolibrary.org/obo/GO_1900740 GO:0046678 biolink:BiologicalProcess response to bacteriocin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation. go.json bacteriocin susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046678 GO:1900743 biolink:BiologicalProcess positive regulation of filamentous growth of a population of unicellular organisms in response to pH Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH. go.json activation of filamentous growth of a population of unicellular organisms in response to pH|up regulation of filamentous growth of a population of unicellular organisms in response to pH|up-regulation of filamentous growth of a population of unicellular organisms in response to pH|upregulation of filamentous growth of a population of unicellular organisms in response to pH http://purl.obolibrary.org/obo/GO_1900743 GO:0046677 biolink:BiologicalProcess response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. go.json antibiotic susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046677 goslim_chembl GO:1900742 biolink:BiologicalProcess negative regulation of filamentous growth of a population of unicellular organisms in response to pH Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH. go.json down regulation of filamentous growth of a population of unicellular organisms in response to pH|down-regulation of filamentous growth of a population of unicellular organisms in response to pH|downregulation of filamentous growth of a population of unicellular organisms in response to pH|inhibition of filamentous growth of a population of unicellular organisms in response to pH http://purl.obolibrary.org/obo/GO_1900742 GO:0046676 biolink:BiologicalProcess negative regulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. go.json down regulation of insulin secretion|down-regulation of insulin secretion|downregulation of insulin secretion|inhibition of insulin secretion http://purl.obolibrary.org/obo/GO_0046676 GO:0046675 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046675 GO:0046674 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046674 GO:0046673 biolink:BiologicalProcess negative regulation of compound eye retinal cell programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. go.json down regulation of retinal cell programmed cell death|down-regulation of retinal cell programmed cell death|downregulation of retinal cell programmed cell death|inhibition of retinal cell programmed cell death|negative regulation of retina cell programmed cell death|negative regulation of retinal cell programmed cell death http://purl.obolibrary.org/obo/GO_0046673 GO:0046672 biolink:BiologicalProcess positive regulation of compound eye retinal cell programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. go.json activation of retinal cell programmed cell death|positive regulation of retinal cell programmed cell death|stimulation of retinal cell programmed cell death|up regulation of retinal cell programmed cell death|up-regulation of retinal cell programmed cell death|upregulation of retinal cell programmed cell death http://purl.obolibrary.org/obo/GO_0046672 GO:0071619 biolink:BiologicalProcess obsolete phosphorylation of RNA polymerase II C-terminal domain serine 2 residues OBSOLETE. The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans. go.json True http://purl.obolibrary.org/obo/GO_0071619 GO:0071618 biolink:MolecularActivity lysophosphatidylethanolamine acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine. go.json http://purl.obolibrary.org/obo/GO_0071618 GO:0071617 biolink:MolecularActivity lysophospholipid acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. go.json http://purl.obolibrary.org/obo/GO_0071617 GO:0071616 biolink:BiologicalProcess acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. go.json acyl-CoA anabolism|acyl-CoA biosynthesis|acyl-CoA formation|acyl-CoA synthesis http://purl.obolibrary.org/obo/GO_0071616 GO:0071615 biolink:BiologicalProcess obsolete oxidative deethylation OBSOLETE. The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. go.json True http://purl.obolibrary.org/obo/GO_0071615 GO:0071614 biolink:MolecularActivity linoleic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid. go.json linoleic acid monooxygenase activity http://purl.obolibrary.org/obo/GO_0071614 GO:0071613 biolink:BiologicalProcess granzyme B production The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json http://purl.obolibrary.org/obo/GO_0071613 gocheck_do_not_annotate GO:0071612 biolink:BiologicalProcess IP-10 production The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CXCL10 production|chemokine (C-C motif) ligand 10 production http://purl.obolibrary.org/obo/GO_0071612 gocheck_do_not_annotate GO:0071611 biolink:BiologicalProcess granulocyte colony-stimulating factor production The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CSF3 production|G-CSF production|colony stimulating factor 3 (granulocyte) production|filgrastim production|granulocyte colony stimulating factor production|lenograstim production|pluripoietin production http://purl.obolibrary.org/obo/GO_0071611 gocheck_do_not_annotate GO:0071610 biolink:BiologicalProcess chemokine (C-C motif) ligand 1 production The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json CCL1 production|T cell activation 3 production|TCA-3 production http://purl.obolibrary.org/obo/GO_0071610 gocheck_do_not_annotate GO:0032039 biolink:CellularComponent integrator complex A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. go.json http://purl.obolibrary.org/obo/GO_0032039 GO:0007079 biolink:BiologicalProcess mitotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis. go.json chromosome migration to spindle pole during mitosis|chromosome movement towards spindle pole during mitosis|mitotic chromosome movement|mitotic chromosome movement to spindle pole|mitotic sister chromosome movement towards spindle pole|sister chromosome movement towards spindle pole during mitosis http://purl.obolibrary.org/obo/GO_0007079 GO:0007078 biolink:BiologicalProcess lamin depolymerization The cell cycle process in which lamin is depolymerized. go.json http://purl.obolibrary.org/obo/GO_0007078 GO:0007077 biolink:BiologicalProcess mitotic nuclear membrane disassembly The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. go.json NEB|local NEB|mitotic nuclear envelope breakdown|mitotic nuclear envelope catabolism|mitotic nuclear envelope degradation|mitotic nuclear envelope disassembly|nuclear envelope breakdown http://purl.obolibrary.org/obo/GO_0007077 GO:0007076 biolink:BiologicalProcess mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. go.json http://purl.obolibrary.org/obo/GO_0007076 GO:0007075 biolink:BiologicalProcess obsolete positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. go.json activation of transcription on exit from mitosis, from Pol III promoter|activation of transcription on exit from mitosis, from RNA polymerase III promoter True http://purl.obolibrary.org/obo/GO_0007075 GO:0032030 biolink:MolecularActivity myosin I light chain binding Binding to a light chain of a myosin I complex. go.json http://purl.obolibrary.org/obo/GO_0032030 GO:0007085 biolink:BiologicalProcess obsolete nuclear membrane vesicle binding to chromatin OBSOLETE. (Was not defined before being made obsolete). go.json nuclear membrane vesicle binding to chromatin True http://purl.obolibrary.org/obo/GO_0007085 GO:0007084 biolink:BiologicalProcess mitotic nuclear membrane reassembly The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge. go.json mitotic nuclear envelope reassembly|nuclear envelope repair|nuclear envelope resealing http://purl.obolibrary.org/obo/GO_0007084 GO:0007083 biolink:BiologicalProcess obsolete mitotic chromosome decondensation OBSOLETE. The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells. go.json True http://purl.obolibrary.org/obo/GO_0007083 GO:0007082 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007082 GO:0007081 biolink:BiologicalProcess obsolete mitotic sister-chromatid adhesion release OBSOLETE. (Was not defined before being made obsolete). go.json mitotic sister-chromatid adhesion release True http://purl.obolibrary.org/obo/GO_0007081 GO:0007080 biolink:BiologicalProcess mitotic metaphase chromosome alignment A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. go.json http://purl.obolibrary.org/obo/GO_0007080 GO:0032038 biolink:MolecularActivity myosin II heavy chain binding Binding to a heavy chain of a myosin II complex. go.json http://purl.obolibrary.org/obo/GO_0032038 GO:0032037 biolink:MolecularActivity myosin I heavy chain binding Binding to a heavy chain of a myosin I complex. go.json http://purl.obolibrary.org/obo/GO_0032037 GO:0032036 biolink:MolecularActivity myosin heavy chain binding Binding to a heavy chain of a myosin complex. go.json http://purl.obolibrary.org/obo/GO_0032036 GO:0032035 biolink:MolecularActivity myosin II tail binding Binding to the tail region of a myosin II heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032035 GO:0032034 biolink:MolecularActivity myosin II head/neck binding Binding to the head/neck region of a myosin II heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032034 GO:0032033 biolink:MolecularActivity myosin II light chain binding Binding to a light chain of a myosin II complex. go.json http://purl.obolibrary.org/obo/GO_0032033 GO:0032032 biolink:MolecularActivity myosin I tail binding Binding to the tail region of a myosin I heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032032 GO:0032031 biolink:MolecularActivity myosin I head/neck binding Binding to the head/neck region of a myosin I heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032031 GO:0032029 biolink:MolecularActivity myosin tail binding Binding to the tail region of a myosin heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032029 GO:0032028 biolink:MolecularActivity myosin head/neck binding Binding to the head/neck region of a myosin heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032028 GO:0007089 biolink:BiologicalProcess traversing start control point of mitotic cell cycle A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity. go.json http://purl.obolibrary.org/obo/GO_0007089 GO:0007088 biolink:BiologicalProcess regulation of mitotic nuclear division Any process that modulates the frequency, rate or extent of mitosis. go.json regulation of mitosis http://purl.obolibrary.org/obo/GO_0007088 GO:0007087 biolink:BiologicalProcess mitotic nuclear pore complex reassembly The cell cycle process in which nuclear pore complexes reform during mitotic cell division. go.json http://purl.obolibrary.org/obo/GO_0007087 GO:0007086 biolink:BiologicalProcess vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly. go.json http://purl.obolibrary.org/obo/GO_0007086 GO:0007096 biolink:BiologicalProcess regulation of exit from mitosis Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. go.json http://purl.obolibrary.org/obo/GO_0007096 GO:0007095 biolink:BiologicalProcess mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. go.json G2 DNA damage checkpoint|G2/M transition DNA damage checkpoint|down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint|mitotic G2 DNA damage checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|signal transduction involved in G2 DNA damage checkpoint|signal transduction involved in G2/M transition DNA damage checkpoint|signal transduction involved in mitotic G2 DNA damage checkpoint|signal transduction involved in mitotic G2/M transition DNA damage checkpoint http://purl.obolibrary.org/obo/GO_0007095 GO:0007094 biolink:BiologicalProcess mitotic spindle assembly checkpoint signaling A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC). go.json Dma1-dependent checkpoint|Mad2-dependent checkpoint|SAC-independent checkpoint|mitotic cell cycle spindle assembly checkpoint|mitotic checkpoint|mitotic spindle assembly checkpoint|mitotic spindle assembly checkpoint signalling|signal transduction involved in Dma1-dependent checkpoint|signal transduction involved in SAC-independent checkpoint|signal transduction involved in mitotic cell cycle spindle assembly checkpoint|signal transduction involved in mitotic spindle assembly checkpoint|signaling cascade involved in Dma1-dependent checkpoint|signaling cascade involved in SAC-independent checkpoint|signaling pathway involved in Dma1-dependent checkpoint|signaling pathway involved in SAC-independent checkpoint|signalling cascade involved in Dma1-dependent checkpoint|signalling cascade involved in SAC-independent checkpoint|signalling pathway involved in Dma1-dependent checkpoint|signalling pathway involved in SAC-independent checkpoint http://purl.obolibrary.org/obo/GO_0007094 GO:0007093 biolink:BiologicalProcess mitotic cell cycle checkpoint signaling A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. go.json mitotic cell cycle checkpoint|mitotic checkpoint|signal transduction involved in mitotic G2/M transition checkpoint|signal transduction involved in mitotic cell cycle G1/S checkpoint|signal transduction involved in mitotic cell cycle checkpoint http://purl.obolibrary.org/obo/GO_0007093 gocheck_do_not_annotate GO:0007092 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007092 GO:0007091 biolink:BiologicalProcess metaphase/anaphase transition of mitotic cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. go.json metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic metaphase/anaphase transition http://purl.obolibrary.org/obo/GO_0007091 GO:0007090 biolink:BiologicalProcess obsolete regulation of S phase of mitotic cell cycle OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle. go.json regulation of S phase of mitotic cell cycle|regulation of S-phase of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0007090 GO:0032027 biolink:MolecularActivity myosin light chain binding Binding to a light chain of a myosin complex. go.json http://purl.obolibrary.org/obo/GO_0032027 GO:0032026 biolink:BiologicalProcess response to magnesium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0032026 GO:0032025 biolink:BiologicalProcess response to cobalt ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. go.json http://purl.obolibrary.org/obo/GO_0032025 GO:0032024 biolink:BiologicalProcess positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. go.json activation of insulin secretion|stimulation of insulin secretion|up regulation of insulin secretion|up-regulation of insulin secretion|upregulation of insulin secretion http://purl.obolibrary.org/obo/GO_0032024 GO:0032023 biolink:BiologicalProcess trypsinogen activation The proteolytic processing of trypsinogen to the active form, trypsin. go.json cleavage of trypsinogen to trypsin http://purl.obolibrary.org/obo/GO_0032023 GO:0032022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032022 GO:0032021 biolink:CellularComponent NELF complex A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing. go.json negative elongation factor complex http://purl.obolibrary.org/obo/GO_0032021 GO:0032020 biolink:BiologicalProcess ISG15-protein conjugation The covalent addition to a protein of ISG15, a ubiquitin-like protein. go.json http://purl.obolibrary.org/obo/GO_0032020 GO:0032019 biolink:CellularComponent mitochondrial cloud A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material. go.json Balbiani body|mitochondrial aggregate http://purl.obolibrary.org/obo/GO_0032019 GO:0032018 biolink:MolecularActivity 2-methylbutanol:NADP oxidoreductase activity Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+. go.json 2-methylbutanal reductase (NADP) activity|2-methylbutyraldehyde reductase (NADP) activity http://purl.obolibrary.org/obo/GO_0032018 GO:0032017 biolink:BiologicalProcess positive regulation of Ran protein signal transduction Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction. go.json activation of Ran protein signal transduction|stimulation of Ran protein signal transduction|up regulation of Ran protein signal transduction|up-regulation of Ran protein signal transduction|upregulation of Ran protein signal transduction http://purl.obolibrary.org/obo/GO_0032017 GO:0007059 biolink:BiologicalProcess chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. Wikipedia:Chromosome_segregation go.json chromosome division|chromosome transmission http://purl.obolibrary.org/obo/GO_0007059 goslim_chembl|goslim_drosophila|goslim_generic|goslim_pir|goslim_yeast|prokaryote_subset GO:0007058 biolink:BiologicalProcess spindle assembly involved in female meiosis II The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. go.json female meiosis II spindle assembly http://purl.obolibrary.org/obo/GO_0007058 GO:0007057 biolink:BiologicalProcess spindle assembly involved in female meiosis I The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. go.json female meiosis I spindle assembly http://purl.obolibrary.org/obo/GO_0007057 GO:0007056 biolink:BiologicalProcess spindle assembly involved in female meiosis The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. go.json female meiotic spindle assembly http://purl.obolibrary.org/obo/GO_0007056 GO:0007055 biolink:BiologicalProcess spindle assembly involved in male meiosis II The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. go.json male meiosis II spindle assembly http://purl.obolibrary.org/obo/GO_0007055 GO:0007054 biolink:BiologicalProcess spindle assembly involved in male meiosis I The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. go.json male meiosis I spindle assembly http://purl.obolibrary.org/obo/GO_0007054 GO:0007053 biolink:BiologicalProcess spindle assembly involved in male meiosis The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007053 GO:0007063 biolink:BiologicalProcess regulation of sister chromatid cohesion Any process that modulates the frequency, rate or extent of sister chromatid cohesion. go.json http://purl.obolibrary.org/obo/GO_0007063 GO:0007062 biolink:BiologicalProcess sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. go.json cohesion-mediated DNA tethering http://purl.obolibrary.org/obo/GO_0007062 GO:0007061 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007061 GO:0007060 biolink:BiologicalProcess male meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male. go.json http://purl.obolibrary.org/obo/GO_0007060 GO:0032016 biolink:BiologicalProcess negative regulation of Ran protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction. go.json down regulation of Ran protein signal transduction|down-regulation of Ran protein signal transduction|downregulation of Ran protein signal transduction|inhibition of Ran protein signal transduction http://purl.obolibrary.org/obo/GO_0032016 GO:0032015 biolink:BiologicalProcess regulation of Ran protein signal transduction Any process that modulates the frequency, rate or extent of Ran protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0032015 GO:0032014 biolink:BiologicalProcess positive regulation of ARF protein signal transduction Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction. go.json activation of ARF protein signal transduction|stimulation of ARF protein signal transduction|up regulation of ARF protein signal transduction|up-regulation of ARF protein signal transduction|upregulation of ARF protein signal transduction http://purl.obolibrary.org/obo/GO_0032014 GO:0032013 biolink:BiologicalProcess negative regulation of ARF protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction. go.json down regulation of ARF protein signal transduction|down-regulation of ARF protein signal transduction|downregulation of ARF protein signal transduction|inhibition of ARF protein signal transduction http://purl.obolibrary.org/obo/GO_0032013 GO:0032012 biolink:BiologicalProcess regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0032012 GO:0032011 biolink:BiologicalProcess ARF protein signal transduction The series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state. go.json http://purl.obolibrary.org/obo/GO_0032011 GO:0032010 biolink:CellularComponent phagolysosome A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. Wikipedia:Phagolysosome go.json late phagocytic vesicle|late phagosome http://purl.obolibrary.org/obo/GO_0032010 GO:0032009 biolink:CellularComponent early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. go.json early phagocytic vesicle http://purl.obolibrary.org/obo/GO_0032009 GO:0032008 biolink:BiologicalProcess positive regulation of TOR signaling Any process that activates or increases the frequency, rate or extent of TOR signaling. go.json activation of TOR signaling pathway|positive regulation of TOR signaling cascade|positive regulation of TOR signaling pathway|positive regulation of TOR signalling pathway|positive regulation of target of rapamycin signaling pathway|positive regulation of target of rapamycin signalling pathway|stimulation of TOR signaling pathway|up regulation of TOR signaling pathway|up-regulation of TOR signaling pathway|upregulation of TOR signaling pathway http://purl.obolibrary.org/obo/GO_0032008 GO:0032007 biolink:BiologicalProcess negative regulation of TOR signaling Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. go.json down regulation of TOR signaling pathway|down-regulation of TOR signaling pathway|downregulation of TOR signaling pathway|inhibition of TOR signaling pathway|negative regulation of TOR signaling cascade|negative regulation of TOR signaling pathway|negative regulation of TOR signalling pathway|negative regulation of target of rapamycin signaling pathway|negative regulation of target of rapamycin signalling pathway http://purl.obolibrary.org/obo/GO_0032007 GO:0032006 biolink:BiologicalProcess regulation of TOR signaling Any process that modulates the frequency, rate or extent of TOR signaling. go.json regulation of TOR signaling cascade|regulation of TOR signaling pathway|regulation of TOR signalling pathway|regulation of target of rapamycin signaling pathway|regulation of target of rapamycin signalling pathway http://purl.obolibrary.org/obo/GO_0032006 GO:0007069 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle. go.json down regulation of transcription from RNA polymerase I promoter during mitosis|down-regulation of transcription from RNA polymerase I promoter during mitosis|downregulation of transcription from RNA polymerase I promoter during mitosis|inhibition of transcription from RNA polymerase I promoter during mitosis|mitotic repression of transcription from Pol I promoter|negative regulation of transcription from Pol I promoter during mitosis|negative regulation of transcription from RNA polymerase I promoter, mitotic True http://purl.obolibrary.org/obo/GO_0007069 GO:0007068 biolink:BiologicalProcess obsolete negative regulation of transcription during mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle. go.json down regulation of transcription during mitosis|down-regulation of transcription during mitosis|downregulation of transcription during mitosis|inhibition of transcription during mitosis|mitotic repression of transcription|negative regulation of transcription, mitotic True http://purl.obolibrary.org/obo/GO_0007068 GO:0007067 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007067 GO:0007066 biolink:BiologicalProcess female meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female. go.json http://purl.obolibrary.org/obo/GO_0007066 GO:0007065 biolink:BiologicalProcess male meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male. go.json http://purl.obolibrary.org/obo/GO_0007065 GO:0007064 biolink:BiologicalProcess mitotic sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. go.json http://purl.obolibrary.org/obo/GO_0007064 GO:0007074 biolink:BiologicalProcess obsolete positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. go.json activation of transcription on exit from mitosis, from Pol II promoter|activation of transcription on exit from mitosis, from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_0007074 GO:0007073 biolink:BiologicalProcess obsolete positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. go.json activation of transcription on exit from mitosis, from Pol I promoter|activation of transcription on exit from mitosis, from RNA polymerase I promoter True http://purl.obolibrary.org/obo/GO_0007073 GO:0007072 biolink:BiologicalProcess obsolete positive regulation of transcription involved in exit from mitosis OBSOLETE. Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. go.json activation of transcription on exit from mitosis True http://purl.obolibrary.org/obo/GO_0007072 GO:0007071 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle. go.json down regulation of transcription from RNA polymerase III promoter during mitosis|down-regulation of transcription from RNA polymerase III promoter during mitosis|downregulation of transcription from RNA polymerase III promoter during mitosis|inhibition of transcription from RNA polymerase III promoter during mitosis|mitotic repression of transcription from Pol III promoter|negative regulation of transcription from Pol III promoter during mitosis|negative regulation of transcription from RNA polymerase III promoter, mitotic True http://purl.obolibrary.org/obo/GO_0007071 GO:0007070 biolink:BiologicalProcess obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle. go.json down regulation of transcription from RNA polymerase II promoter during mitosis|down-regulation of transcription from RNA polymerase II promoter during mitosis|downregulation of transcription from RNA polymerase II promoter during mitosis|inhibition of transcription from RNA polymerase II promoter during mitosis|mitotic repression of transcription from Pol II promoter|negative regulation of transcription from Pol II promoter during mitosis|negative regulation of transcription from RNA polymerase II promoter, mitotic True http://purl.obolibrary.org/obo/GO_0007070 GO:0032005 biolink:BiologicalProcess signal transduction involved in positive regulation of conjugation with cellular fusion The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. go.json http://purl.obolibrary.org/obo/GO_0032005 GO:0032004 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032004 GO:0032003 biolink:MolecularActivity interleukin-28 receptor binding Binding to an interleukin-28 receptor. go.json IL-28|interleukin-28 receptor ligand http://purl.obolibrary.org/obo/GO_0032003 GO:0032002 biolink:CellularComponent interleukin-28 receptor complex A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1). go.json IL-28 receptor complex http://purl.obolibrary.org/obo/GO_0032002 GO:0032001 biolink:MolecularActivity 1,4-alpha-glucan 6-alpha-glucosyltransferase activity Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan. EC:2.4.1.24|MetaCyc:2.4.1.24-RXN go.json 1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity|1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity|D-glucosyltransferase|T-enzyme|oligoglucan-branching glycosyltransferase activity http://purl.obolibrary.org/obo/GO_0032001 GO:0032000 biolink:BiologicalProcess positive regulation of fatty acid beta-oxidation Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. go.json activation of fatty acid beta-oxidation|stimulation of fatty acid beta-oxidation|up regulation of fatty acid beta-oxidation|up-regulation of fatty acid beta-oxidation|upregulation of fatty acid beta-oxidation http://purl.obolibrary.org/obo/GO_0032000 GO:0007039 biolink:BiologicalProcess protein catabolic process in the vacuole The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. go.json vacuolar protein breakdown|vacuolar protein catabolic process|vacuolar protein catabolism|vacuolar protein degradation http://purl.obolibrary.org/obo/GO_0007039 GO:0007038 biolink:BiologicalProcess endocytosed protein transport to vacuole The directed movement of proteins imported into a cell by endocytosis to the vacuole. go.json delivery of endocytosed proteins to the vacuole http://purl.obolibrary.org/obo/GO_0007038 GO:0007037 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007037 GO:0007036 biolink:BiologicalProcess vacuolar calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings. go.json http://purl.obolibrary.org/obo/GO_0007036 GO:0007035 biolink:BiologicalProcess vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. go.json http://purl.obolibrary.org/obo/GO_0007035 GO:0007034 biolink:BiologicalProcess vacuolar transport The directed movement of substances into, out of or within a vacuole. go.json http://purl.obolibrary.org/obo/GO_0007034 goslim_chembl GO:0007033 biolink:BiologicalProcess vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. go.json vacuolar assembly|vacuole biogenesis|vacuole organisation|vacuole organization and biogenesis http://purl.obolibrary.org/obo/GO_0007033 goslim_drosophila|goslim_pir|goslim_yeast GO:0007032 biolink:BiologicalProcess endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. go.json endosome organisation|endosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0007032 goslim_pir GO:0007031 biolink:BiologicalProcess peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. go.json peroxisome organisation|peroxisome organization and biogenesis http://purl.obolibrary.org/obo/GO_0007031 goslim_drosophila|goslim_generic|goslim_pir|goslim_pombe|goslim_yeast GO:0007041 biolink:BiologicalProcess lysosomal transport The directed movement of substances into, out of or within a lysosome. go.json http://purl.obolibrary.org/obo/GO_0007041 GO:0007040 biolink:BiologicalProcess lysosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. go.json lysosome organisation|lysosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0007040 goslim_generic GO:0007049 biolink:BiologicalProcess cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. Wikipedia:Cell_cycle go.json cell-division cycle http://purl.obolibrary.org/obo/GO_0007049 gocheck_do_not_manually_annotate|goslim_agr|goslim_candida|goslim_chembl|goslim_flybase_ribbon|goslim_pir|goslim_plant GO:0007048 biolink:BiologicalProcess obsolete oncogenesis OBSOLETE. (Was not defined before being made obsolete). go.json oncogenesis True http://purl.obolibrary.org/obo/GO_0007048 GO:0007047 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007047 GO:0007046 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007046 GO:0007045 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007045 GO:0007044 biolink:BiologicalProcess cell-substrate junction assembly The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. go.json cell-substrate adherens junction assembly http://purl.obolibrary.org/obo/GO_0007044 GO:0007043 biolink:BiologicalProcess cell-cell junction assembly The aggregation, arrangement and bonding together of a set of components to form a junction between cells. go.json intercellular junction assembly http://purl.obolibrary.org/obo/GO_0007043 GO:0007042 biolink:BiologicalProcess lysosomal lumen acidification Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. go.json lysosome pH reduction http://purl.obolibrary.org/obo/GO_0007042 GO:0007052 biolink:BiologicalProcess mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. go.json mitotic spindle organisation|mitotic spindle organisation in nucleus|mitotic spindle organization and biogenesis|mitotic spindle organization and biogenesis in cell nucleus|mitotic spindle organization and biogenesis in nucleus|mitotic spindle organization in nucleus|mitotic spindle stabilization|spindle organization and biogenesis during mitosis|spindle organization and biogenesis in nucleus during mitosis http://purl.obolibrary.org/obo/GO_0007052 GO:0007051 biolink:BiologicalProcess spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. go.json spindle organisation|spindle organization and biogenesis|spindle stabilization http://purl.obolibrary.org/obo/GO_0007051 GO:0007050 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007050 GO:0007019 biolink:BiologicalProcess microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule. go.json microtubule catastrophe|microtubule depolymerization during nuclear congression|microtubule disassembly|microtubule shortening http://purl.obolibrary.org/obo/GO_0007019 GO:0007018 biolink:BiologicalProcess microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. go.json http://purl.obolibrary.org/obo/GO_0007018 goslim_drosophila|goslim_generic GO:0007017 biolink:BiologicalProcess microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. go.json http://purl.obolibrary.org/obo/GO_0007017 goslim_chembl GO:0007016 biolink:BiologicalProcess obsolete cytoskeletal anchoring at plasma membrane OBSOLETE. A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane. go.json cytoskeletal anchoring activity True http://purl.obolibrary.org/obo/GO_0007016 GO:0007015 biolink:BiologicalProcess actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. go.json actin filament organisation|regulation of actin filament localization http://purl.obolibrary.org/obo/GO_0007015 GO:0007014 biolink:BiologicalProcess actin ubiquitination The modification of actin by addition of ubiquitin groups. go.json indirect flight muscle actin ubiquitination http://purl.obolibrary.org/obo/GO_0007014 GO:0007013 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007013 GO:0007012 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007012 GO:0007011 biolink:BiologicalProcess obsolete regulation of cytoskeleton OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton. go.json regulation of cytoskeleton True http://purl.obolibrary.org/obo/GO_0007011 GO:0007010 biolink:BiologicalProcess cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. go.json cytoskeletal organization and biogenesis|cytoskeletal regulator activity|cytoskeleton organisation|cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0007010 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_yeast|prokaryote_subset GO:0007029 biolink:BiologicalProcess endoplasmic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. go.json ER organisation|ER organization and biogenesis|endoplasmic reticulum morphology|endoplasmic reticulum organisation|endoplasmic reticulum organization and biogenesis http://purl.obolibrary.org/obo/GO_0007029 goslim_pir GO:0007028 biolink:BiologicalProcess cytoplasm organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. go.json cytoplasm organisation|cytoplasm organization and biogenesis http://purl.obolibrary.org/obo/GO_0007028 goslim_pir GO:0007027 biolink:BiologicalProcess negative regulation of axonemal microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. go.json axonemal microtubule stabilization|negative regulation of microtubule depolymerization in axoneme http://purl.obolibrary.org/obo/GO_0007027 GO:0007026 biolink:BiologicalProcess negative regulation of microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. go.json down regulation of microtubule depolymerization|down-regulation of microtubule depolymerization|downregulation of microtubule depolymerization|inhibition of microtubule depolymerization|microtubule rescue|microtubule stabilization|negative regulation of microtubule catastrophe|negative regulation of microtubule disassembly http://purl.obolibrary.org/obo/GO_0007026 GO:0007025 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007025 GO:0007024 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007024 GO:0007023 biolink:BiologicalProcess post-chaperonin tubulin folding pathway Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. go.json http://purl.obolibrary.org/obo/GO_0007023 GO:0007022 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007022 GO:0007021 biolink:BiologicalProcess tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. go.json tubulin assembly|tubulin folding|tubulin-specific chaperone activity http://purl.obolibrary.org/obo/GO_0007021 GO:0007020 biolink:BiologicalProcess microtubule nucleation The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). Wikipedia:Microtubule_nucleation go.json http://purl.obolibrary.org/obo/GO_0007020 GO:0007030 biolink:BiologicalProcess Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. go.json Golgi apparatus organization|Golgi organisation|Golgi organization and biogenesis http://purl.obolibrary.org/obo/GO_0007030 goslim_pir GO:0071594 biolink:BiologicalProcess thymocyte aggregation The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. go.json T cell precursor aggregation|immature T cell aggregation|immature T-cell aggregation|immature T-lymphocyte aggregation|thymic lymphocyte aggregation http://purl.obolibrary.org/obo/GO_0071594 GO:0071593 biolink:BiologicalProcess lymphocyte aggregation The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0071593 GO:0071592 biolink:BiologicalProcess nicotinic acid riboside biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid. go.json D-ribosylnicotinic acid biosynthetic process|nicotinic acid riboside anabolism|nicotinic acid riboside biosynthesis|nicotinic acid riboside formation|nicotinic acid riboside synthesis http://purl.obolibrary.org/obo/GO_0071592 GO:0071591 biolink:BiologicalProcess nicotinic acid riboside metabolic process The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid. go.json D-ribosylnicotinic acid metabolic process|nicotinic acid riboside metabolism http://purl.obolibrary.org/obo/GO_0071591 GO:0071590 biolink:BiologicalProcess nicotinamide riboside biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. go.json N-ribosylnicotinamide biosynthetic process|nicotinamide riboside anabolism|nicotinamide riboside biosynthesis|nicotinamide riboside formation|nicotinamide riboside synthesis http://purl.obolibrary.org/obo/GO_0071590 GO:0071599 biolink:BiologicalProcess otic vesicle development The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. go.json http://purl.obolibrary.org/obo/GO_0071599 GO:0071598 biolink:CellularComponent neuronal ribonucleoprotein granule A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli. go.json neuronal RNA granule|neuronal RNP granule http://purl.obolibrary.org/obo/GO_0071598 GO:0071597 biolink:CellularComponent cellular birth scar Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation. go.json http://purl.obolibrary.org/obo/GO_0071597 GO:0071596 biolink:BiologicalProcess ubiquitin-dependent protein catabolic process via the N-end rule pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. go.json ubiquitin-dependent protein breakdown via the N-end rule pathway|ubiquitin-dependent protein catabolism via the N-end rule pathway|ubiquitin-dependent protein degradation via the N-end rule pathway http://purl.obolibrary.org/obo/GO_0071596 GO:0071595 biolink:CellularComponent Nem1-Spo7 phosphatase complex A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p. go.json http://purl.obolibrary.org/obo/GO_0071595 GO:1900639 biolink:BiologicalProcess positive regulation of asperfuranone biosynthetic process Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process. go.json activation of asperfuranone anabolism|activation of asperfuranone biosynthesis|activation of asperfuranone biosynthetic process|activation of asperfuranone formation|activation of asperfuranone synthesis|positive regulation of asperfuranone anabolism|positive regulation of asperfuranone biosynthesis|positive regulation of asperfuranone formation|positive regulation of asperfuranone synthesis|up regulation of asperfuranone anabolism|up regulation of asperfuranone biosynthesis|up regulation of asperfuranone biosynthetic process|up regulation of asperfuranone formation|up regulation of asperfuranone synthesis|up-regulation of asperfuranone anabolism|up-regulation of asperfuranone biosynthesis|up-regulation of asperfuranone biosynthetic process|up-regulation of asperfuranone formation|up-regulation of asperfuranone synthesis|upregulation of asperfuranone anabolism|upregulation of asperfuranone biosynthesis|upregulation of asperfuranone biosynthetic process|upregulation of asperfuranone formation|upregulation of asperfuranone synthesis http://purl.obolibrary.org/obo/GO_1900639 GO:0046561 biolink:MolecularActivity obsolete penicillopepsin activity OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen. go.json Penicillium aspartic proteinase activity|Penicillium caseicolum aspartic proteinase activity|Penicillium citrinum acid proteinase activity|Penicillium citrinum aspartic proteinase activity|Penicillium cyclopium acid proteinase activity|Penicillium duponti aspartic proteinase activity|Penicillium expansum acid proteinase activity|Penicillium expansum aspartic proteinase activity|Penicillium janthinellum acid proteinase activity|Penicillium janthinellum aspartic protease activity|Penicillium janthinellum aspartic proteinase activity|Penicillium roqueforti acid proteinase activity|acid protease A|penicillopepsin activity|peptidase A activity True http://purl.obolibrary.org/obo/GO_0046561 GO:1900638 biolink:BiologicalProcess negative regulation of asperfuranone biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process. go.json down regulation of asperfuranone anabolism|down regulation of asperfuranone biosynthesis|down regulation of asperfuranone biosynthetic process|down regulation of asperfuranone formation|down regulation of asperfuranone synthesis|down-regulation of asperfuranone anabolism|down-regulation of asperfuranone biosynthesis|down-regulation of asperfuranone biosynthetic process|down-regulation of asperfuranone formation|down-regulation of asperfuranone synthesis|downregulation of asperfuranone anabolism|downregulation of asperfuranone biosynthesis|downregulation of asperfuranone biosynthetic process|downregulation of asperfuranone formation|downregulation of asperfuranone synthesis|inhibition of asperfuranone anabolism|inhibition of asperfuranone biosynthesis|inhibition of asperfuranone biosynthetic process|inhibition of asperfuranone formation|inhibition of asperfuranone synthesis|negative regulation of asperfuranone anabolism|negative regulation of asperfuranone biosynthesis|negative regulation of asperfuranone formation|negative regulation of asperfuranone synthesis http://purl.obolibrary.org/obo/GO_1900638 GO:0046560 biolink:MolecularActivity obsolete scytalidopepsin B activity OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin. go.json Ganoderma lucidum aspartic proteinase activity|Ganoderma lucidum carboxyl proteinase activity|SLB|Scytalidium aspartic proteinase B activity|Scytalidium lignicolum aspartic proteinase B|scytalidopepsin B activity True http://purl.obolibrary.org/obo/GO_0046560 GO:1900635 biolink:BiologicalProcess heptadecane metabolic process The chemical reactions and pathways involving heptadecane. go.json heptadecane metabolism http://purl.obolibrary.org/obo/GO_1900635 GO:1900634 biolink:BiologicalProcess pentadecane biosynthetic process The chemical reactions and pathways resulting in the formation of pentadecane. go.json pentadecane anabolism|pentadecane biosynthesis|pentadecane formation|pentadecane synthesis http://purl.obolibrary.org/obo/GO_1900634 GO:1900637 biolink:BiologicalProcess regulation of asperfuranone biosynthetic process Any process that modulates the frequency, rate or extent of asperfuranone biosynthetic process. go.json regulation of asperfuranone anabolism|regulation of asperfuranone biosynthesis|regulation of asperfuranone formation|regulation of asperfuranone synthesis http://purl.obolibrary.org/obo/GO_1900637 GO:1900636 biolink:BiologicalProcess heptadecane biosynthetic process The chemical reactions and pathways resulting in the formation of heptadecane. go.json heptadecane anabolism|heptadecane biosynthesis|heptadecane formation|heptadecane synthesis http://purl.obolibrary.org/obo/GO_1900636 GO:0046569 biolink:MolecularActivity glyoxal oxidase activity Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2. go.json GLOX http://purl.obolibrary.org/obo/GO_0046569 GO:1900631 biolink:BiologicalProcess tridecane metabolic process The chemical reactions and pathways involving tridecane. go.json tridecane metabolism http://purl.obolibrary.org/obo/GO_1900631 GO:0046568 biolink:MolecularActivity 3-methylbutanol:NAD(P) oxidoreductase activity Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde. EC:1.1.1.265|MetaCyc:1.1.1.265-RXN go.json 3-methylbutanal reductase [NAD(P)] activity|3-methylbutyraldehyde reductase activity|isoamyl alcohol oxidase activity http://purl.obolibrary.org/obo/GO_0046568 GO:1900630 biolink:BiologicalProcess methanophenazine biosynthetic process The chemical reactions and pathways resulting in the formation of methanophenazine. go.json methanophenazine anabolism|methanophenazine biosynthesis|methanophenazine formation|methanophenazine synthesis http://purl.obolibrary.org/obo/GO_1900630 GO:1900633 biolink:BiologicalProcess pentadecane metabolic process The chemical reactions and pathways involving pentadecane. go.json pentadecane metabolism http://purl.obolibrary.org/obo/GO_1900633 GO:0046567 biolink:MolecularActivity aphidicolan-16 beta-ol synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate. EC:4.2.3.42|KEGG_REACTION:R06313|MetaCyc:RXN-10631|RHEA:26213 go.json 9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming) http://purl.obolibrary.org/obo/GO_0046567 GO:1900632 biolink:BiologicalProcess tridecane biosynthetic process The chemical reactions and pathways resulting in the formation of tridecane. go.json tridecane anabolism|tridecane biosynthesis|tridecane formation|tridecane synthesis http://purl.obolibrary.org/obo/GO_1900632 GO:0046566 biolink:MolecularActivity DOPA dioxygenase activity Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid. MetaCyc:RXN-8460 go.json dihydroxyphenylalanine dioxygenase activity http://purl.obolibrary.org/obo/GO_0046566 GO:0046565 biolink:MolecularActivity 3-dehydroshikimate dehydratase activity Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. EC:4.2.1.118|MetaCyc:DHSHIKIMATE-DEHYDRO-RXN|RHEA:24848 go.json http://purl.obolibrary.org/obo/GO_0046565 GO:0046564 biolink:MolecularActivity oxalate decarboxylase activity Catalysis of the reaction: H+ + oxalate = CO2 + formate. EC:4.1.1.2|KEGG_REACTION:R00522|MetaCyc:OXALATE-DECARBOXYLASE-RXN|RHEA:16509 go.json oxalate carboxy-lyase (formate-forming)|oxalate carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0046564 GO:0046563 biolink:MolecularActivity methanol oxidase activity Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde. EC:1.1.3.-|MetaCyc:METHANOL-OXIDASE-RXN go.json http://purl.obolibrary.org/obo/GO_0046563 GO:0046562 biolink:MolecularActivity glucose oxidase activity Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2. EC:1.1.3.4|KEGG_REACTION:R01522|MetaCyc:GLUCOSE-OXIDASE-RXN|RHEA:11428 go.json D-glucose oxidase activity|D-glucose-1-oxidase activity|GOD activity|beta-D-glucose oxidase activity|beta-D-glucose:oxygen 1-oxido-reductase activity|beta-D-glucose:oxygen 1-oxidoreductase activity|beta-D-glucose:quinone oxidoreductase activity|corylophyline|deoxin-1|glucose aerodehydrogenase activity|glucose oxyhydrase activity|microcid|penatin http://purl.obolibrary.org/obo/GO_0046562 GO:0071529 biolink:BiologicalProcess cementum mineralization The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum. go.json cementum formation http://purl.obolibrary.org/obo/GO_0071529 GO:0071528 biolink:BiologicalProcess tRNA re-export from nucleus The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export. go.json tRNA reexport from nucleus http://purl.obolibrary.org/obo/GO_0071528 GO:0071527 biolink:BiologicalProcess semaphorin-plexin signaling pathway involved in outflow tract morphogenesis The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis. go.json semaphorin-plexin signalling pathway involved in outflow tract morphogenesis http://purl.obolibrary.org/obo/GO_0071527 GO:0071526 biolink:BiologicalProcess semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. go.json semaphorin-plexin signalling pathway http://purl.obolibrary.org/obo/GO_0071526 GO:0071525 biolink:BiologicalProcess pyrrolysine metabolic process The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine. go.json monomethylamine methyltransferase cofactor lysine adduct metabolic process|pyrrolysine metabolism http://purl.obolibrary.org/obo/GO_0071525 GO:0071524 biolink:BiologicalProcess pyrrolysine biosynthetic process The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine. go.json monomethylamine methyltransferase cofactor lysine adduct biosynthetic process|pyrrolysine anabolism|pyrrolysine biosynthesis|pyrrolysine formation|pyrrolysine synthesis http://purl.obolibrary.org/obo/GO_0071524 GO:0071523 biolink:BiologicalProcess obsolete TIR domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction. go.json True http://purl.obolibrary.org/obo/GO_0071523 GO:0071522 biolink:MolecularActivity ureidoglycine aminohydrolase activity Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3. EC:3.5.3.26|MetaCyc:URUR-RXN|RHEA:25241 go.json http://purl.obolibrary.org/obo/GO_0071522 GO:0071521 biolink:CellularComponent Cdc42 GTPase complex A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signaling pathway. go.json Ras1-Scd1-Scd2-Cdc42-Shk1 complex http://purl.obolibrary.org/obo/GO_0071521 GO:0071520 biolink:BiologicalProcess actomyosin contractile ring assembly actin filament bundle convergence A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring. go.json actin filament bundle convergence involved in actomyosin contractile ring formation|actin filament bundle convergence involved in cytokinetic actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_0071520 GO:0046572 biolink:MolecularActivity versicolorin B synthase activity Catalysis of the reaction: versiconal = versicolorin B + H2O. EC:4.2.1.143|MetaCyc:RXN-9494|RHEA:33859 go.json http://purl.obolibrary.org/obo/GO_0046572 GO:1900649 biolink:BiologicalProcess regulation of dehydroaustinol biosynthetic process Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process. go.json regulation of dehydroaustinol anabolism|regulation of dehydroaustinol biosynthesis|regulation of dehydroaustinol formation|regulation of dehydroaustinol synthesis http://purl.obolibrary.org/obo/GO_1900649 GO:0046571 biolink:MolecularActivity aspartate-2-keto-4-methylthiobutyrate transaminase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate. go.json http://purl.obolibrary.org/obo/GO_0046571 GO:0046570 biolink:MolecularActivity methylthioribulose 1-phosphate dehydratase activity Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O. EC:4.2.1.109|KEGG_REACTION:R07392|MetaCyc:R145-RXN|RHEA:15549|Reactome:R-HSA-1237140 go.json 1-PMT-ribulose dehydratase activity|5-methylthioribulose-1-phosphate 4-dehydratase activity|S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]|S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity|S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]|methylthioribulose-1-phosphate dehydratase activity http://purl.obolibrary.org/obo/GO_0046570 GO:1900646 biolink:BiologicalProcess regulation of chanoclavine-I aldehyde biosynthetic process Any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process. go.json regulation of chanoclavine-I aldehyde anabolism|regulation of chanoclavine-I aldehyde biosynthesis|regulation of chanoclavine-I aldehyde formation|regulation of chanoclavine-I aldehyde synthesis http://purl.obolibrary.org/obo/GO_1900646 GO:1900645 biolink:BiologicalProcess obsolete positive regulation of chanoclavine-I biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of chanoclavine-I biosynthetic process. go.json activation of chanoclavine-I anabolism|activation of chanoclavine-I biosynthesis|activation of chanoclavine-I biosynthetic process|activation of chanoclavine-I formation|activation of chanoclavine-I synthesis|positive regulation of chanoclavine-I anabolism|positive regulation of chanoclavine-I biosynthesis|positive regulation of chanoclavine-I formation|positive regulation of chanoclavine-I synthesis|up regulation of chanoclavine-I anabolism|up regulation of chanoclavine-I biosynthesis|up regulation of chanoclavine-I biosynthetic process|up regulation of chanoclavine-I formation|up regulation of chanoclavine-I synthesis|up-regulation of chanoclavine-I anabolism|up-regulation of chanoclavine-I biosynthesis|up-regulation of chanoclavine-I biosynthetic process|up-regulation of chanoclavine-I formation|up-regulation of chanoclavine-I synthesis|upregulation of chanoclavine-I anabolism|upregulation of chanoclavine-I biosynthesis|upregulation of chanoclavine-I biosynthetic process|upregulation of chanoclavine-I formation|upregulation of chanoclavine-I synthesis True http://purl.obolibrary.org/obo/GO_1900645 GO:1900648 biolink:BiologicalProcess positive regulation of chanoclavine-I aldehyde biosynthetic process Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process. go.json activation of chanoclavine-I aldehyde anabolism|activation of chanoclavine-I aldehyde biosynthesis|activation of chanoclavine-I aldehyde biosynthetic process|activation of chanoclavine-I aldehyde formation|activation of chanoclavine-I aldehyde synthesis|positive regulation of chanoclavine-I aldehyde anabolism|positive regulation of chanoclavine-I aldehyde biosynthesis|positive regulation of chanoclavine-I aldehyde formation|positive regulation of chanoclavine-I aldehyde synthesis|up regulation of chanoclavine-I aldehyde anabolism|up regulation of chanoclavine-I aldehyde biosynthesis|up regulation of chanoclavine-I aldehyde biosynthetic process|up regulation of chanoclavine-I aldehyde formation|up regulation of chanoclavine-I aldehyde synthesis|up-regulation of chanoclavine-I aldehyde anabolism|up-regulation of chanoclavine-I aldehyde biosynthesis|up-regulation of chanoclavine-I aldehyde biosynthetic process|up-regulation of chanoclavine-I aldehyde formation|up-regulation of chanoclavine-I aldehyde synthesis|upregulation of chanoclavine-I aldehyde anabolism|upregulation of chanoclavine-I aldehyde biosynthesis|upregulation of chanoclavine-I aldehyde biosynthetic process|upregulation of chanoclavine-I aldehyde formation|upregulation of chanoclavine-I aldehyde synthesis http://purl.obolibrary.org/obo/GO_1900648 GO:1900647 biolink:BiologicalProcess negative regulation of chanoclavine-I aldehyde biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process. go.json down regulation of chanoclavine-I aldehyde anabolism|down regulation of chanoclavine-I aldehyde biosynthesis|down regulation of chanoclavine-I aldehyde biosynthetic process|down regulation of chanoclavine-I aldehyde formation|down regulation of chanoclavine-I aldehyde synthesis|down-regulation of chanoclavine-I aldehyde anabolism|down-regulation of chanoclavine-I aldehyde biosynthesis|down-regulation of chanoclavine-I aldehyde biosynthetic process|down-regulation of chanoclavine-I aldehyde formation|down-regulation of chanoclavine-I aldehyde synthesis|downregulation of chanoclavine-I aldehyde anabolism|downregulation of chanoclavine-I aldehyde biosynthesis|downregulation of chanoclavine-I aldehyde biosynthetic process|downregulation of chanoclavine-I aldehyde formation|downregulation of chanoclavine-I aldehyde synthesis|inhibition of chanoclavine-I aldehyde anabolism|inhibition of chanoclavine-I aldehyde biosynthesis|inhibition of chanoclavine-I aldehyde biosynthetic process|inhibition of chanoclavine-I aldehyde formation|inhibition of chanoclavine-I aldehyde synthesis|negative regulation of chanoclavine-I aldehyde anabolism|negative regulation of chanoclavine-I aldehyde biosynthesis|negative regulation of chanoclavine-I aldehyde formation|negative regulation of chanoclavine-I aldehyde synthesis http://purl.obolibrary.org/obo/GO_1900647 GO:1900642 biolink:BiologicalProcess positive regulation of austinol biosynthetic process Any process that activates or increases the frequency, rate or extent of austinol biosynthetic process. go.json activation of austinol anabolism|activation of austinol biosynthesis|activation of austinol biosynthetic process|activation of austinol formation|activation of austinol synthesis|positive regulation of austinol anabolism|positive regulation of austinol biosynthesis|positive regulation of austinol formation|positive regulation of austinol synthesis|up regulation of austinol anabolism|up regulation of austinol biosynthesis|up regulation of austinol biosynthetic process|up regulation of austinol formation|up regulation of austinol synthesis|up-regulation of austinol anabolism|up-regulation of austinol biosynthesis|up-regulation of austinol biosynthetic process|up-regulation of austinol formation|up-regulation of austinol synthesis|upregulation of austinol anabolism|upregulation of austinol biosynthesis|upregulation of austinol biosynthetic process|upregulation of austinol formation|upregulation of austinol synthesis http://purl.obolibrary.org/obo/GO_1900642 GO:0046579 biolink:BiologicalProcess positive regulation of Ras protein signal transduction Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. go.json activation of Ras protein signal transduction|stimulation of Ras protein signal transduction|up regulation of Ras protein signal transduction|up-regulation of Ras protein signal transduction|upregulation of Ras protein signal transduction http://purl.obolibrary.org/obo/GO_0046579 GO:1900641 biolink:BiologicalProcess negative regulation of austinol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of austinol biosynthetic process. go.json down regulation of austinol anabolism|down regulation of austinol biosynthesis|down regulation of austinol biosynthetic process|down regulation of austinol formation|down regulation of austinol synthesis|down-regulation of austinol anabolism|down-regulation of austinol biosynthesis|down-regulation of austinol biosynthetic process|down-regulation of austinol formation|down-regulation of austinol synthesis|downregulation of austinol anabolism|downregulation of austinol biosynthesis|downregulation of austinol biosynthetic process|downregulation of austinol formation|downregulation of austinol synthesis|inhibition of austinol anabolism|inhibition of austinol biosynthesis|inhibition of austinol biosynthetic process|inhibition of austinol formation|inhibition of austinol synthesis|negative regulation of austinol anabolism|negative regulation of austinol biosynthesis|negative regulation of austinol formation|negative regulation of austinol synthesis http://purl.obolibrary.org/obo/GO_1900641 GO:1900644 biolink:BiologicalProcess obsolete negative regulation of chanoclavine-I biosynthetic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I biosynthetic process. go.json down regulation of chanoclavine-I anabolism|down regulation of chanoclavine-I biosynthesis|down regulation of chanoclavine-I biosynthetic process|down regulation of chanoclavine-I formation|down regulation of chanoclavine-I synthesis|down-regulation of chanoclavine-I anabolism|down-regulation of chanoclavine-I biosynthesis|down-regulation of chanoclavine-I biosynthetic process|down-regulation of chanoclavine-I formation|down-regulation of chanoclavine-I synthesis|downregulation of chanoclavine-I anabolism|downregulation of chanoclavine-I biosynthesis|downregulation of chanoclavine-I biosynthetic process|downregulation of chanoclavine-I formation|downregulation of chanoclavine-I synthesis|inhibition of chanoclavine-I anabolism|inhibition of chanoclavine-I biosynthesis|inhibition of chanoclavine-I biosynthetic process|inhibition of chanoclavine-I formation|inhibition of chanoclavine-I synthesis|negative regulation of chanoclavine-I anabolism|negative regulation of chanoclavine-I biosynthesis|negative regulation of chanoclavine-I formation|negative regulation of chanoclavine-I synthesis True http://purl.obolibrary.org/obo/GO_1900644 GO:0046578 biolink:BiologicalProcess regulation of Ras protein signal transduction Any process that modulates the frequency, rate or extent of Ras protein signal transduction. go.json http://purl.obolibrary.org/obo/GO_0046578 GO:1900643 biolink:BiologicalProcess obsolete regulation of chanoclavine-I biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of chanoclavine-I biosynthetic process. go.json regulation of chanoclavine-I anabolism|regulation of chanoclavine-I biosynthesis|regulation of chanoclavine-I formation|regulation of chanoclavine-I synthesis True http://purl.obolibrary.org/obo/GO_1900643 GO:0046577 biolink:MolecularActivity long-chain-alcohol oxidase activity Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. EC:1.1.3.20|MetaCyc:RXN-4444|RHEA:22756 go.json fatty alcohol oxidase activity|fatty alcohol:oxygen oxidoreductase activity|long-chain fatty acid oxidase activity|long-chain fatty alcohol oxidase activity|long-chain-alcohol:oxygen oxidoreductase activity http://purl.obolibrary.org/obo/GO_0046577 GO:0046576 biolink:MolecularActivity rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue. go.json rhamnogalacturonase B activity http://purl.obolibrary.org/obo/GO_0046576 GO:0046575 biolink:MolecularActivity rhamnogalacturonan acetylesterase activity Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan. go.json http://purl.obolibrary.org/obo/GO_0046575 GO:1900640 biolink:BiologicalProcess regulation of austinol biosynthetic process Any process that modulates the frequency, rate or extent of austinol biosynthetic process. go.json regulation of austinol anabolism|regulation of austinol biosynthesis|regulation of austinol formation|regulation of austinol synthesis http://purl.obolibrary.org/obo/GO_1900640 GO:0046574 biolink:MolecularActivity glycuronidase activity Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid. go.json glucuronyl hydrolase activity http://purl.obolibrary.org/obo/GO_0046574 GO:0046573 biolink:MolecularActivity lactonohydrolase activity Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group. go.json http://purl.obolibrary.org/obo/GO_0046573 GO:0071519 biolink:BiologicalProcess actomyosin contractile ring actin filament bundle assembly A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis. go.json actin filament bundle assembly involved in actomyosin contractile ring formation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly http://purl.obolibrary.org/obo/GO_0071519 GO:0071518 biolink:MolecularActivity autoinducer-2 kinase activity Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP. MetaCyc:RXN0-5461|RHEA:15377 go.json 4,5-dihydroxy-pentane-2,3-dione kinase activity http://purl.obolibrary.org/obo/GO_0071518 GO:0071517 biolink:BiologicalProcess obsolete maintenance of imprinting at mating-type locus OBSOLETE. Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. go.json mating type determination, maintenance of imprinting True http://purl.obolibrary.org/obo/GO_0071517 GO:0071516 biolink:BiologicalProcess obsolete establishment of imprinting at mating-type locus OBSOLETE. The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. go.json mating type determination, establishment of imprinting True http://purl.obolibrary.org/obo/GO_0071516 GO:0071515 biolink:BiologicalProcess mating-type locus imprinting A genomic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. go.json genetic imprinting at mating-type locus|genomic imprinting at mating-type locus|mating type determination, imprinting http://purl.obolibrary.org/obo/GO_0071515 GO:0071514 biolink:BiologicalProcess genomic imprinting The establishment of epigenetic modifications (imprints) during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation. Wikipedia:Genomic_imprinting go.json DNA imprinting|establishment of genomic imprinting|genetic imprinting http://purl.obolibrary.org/obo/GO_0071514 GO:0071513 biolink:CellularComponent phosphopantothenoylcysteine decarboxylase complex A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces. go.json http://purl.obolibrary.org/obo/GO_0071513 GO:0071512 biolink:BiologicalProcess obsolete MAPK import into nucleus involved in conjugation with cellular fusion OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion. go.json MAPK import into nucleus involved in mating response|conjugation with cellular fusion, MAPK import into nucleus|conjugation with cellular fusion, nuclear translocation of MAPK|nuclear translocation of MAPK involved in conjugation with cellular fusion|nuclear translocation of MAPK involved in mating response True http://purl.obolibrary.org/obo/GO_0071512 GO:0071511 biolink:BiologicalProcess obsolete inactivation of MAPK activity involved in conjugation with cellular fusion OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion. go.json conjugation with cellular fusion, inactivation of MAPK activity|conjugation with cellular fusion, termination of MAPK activity|inactivation of MAPK activity involved in mating response|termination of MAPK activity during conjugation with cellular fusion True http://purl.obolibrary.org/obo/GO_0071511 GO:0071510 biolink:BiologicalProcess obsolete activation of MAPKKK activity involved in conjugation with cellular fusion OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion. go.json activation of MAP kinase kinase kinase activity during conjugation with cellular fusion|activation of MAPKKK activity involved in mating response|conjugation with cellular fusion, activation of MAP kinase kinase kinase activity|conjugation with cellular fusion, activation of MAPKKK activity True http://purl.obolibrary.org/obo/GO_0071510 GO:0095500 biolink:BiologicalProcess acetylcholine receptor signaling pathway The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. go.json acetylcholine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0095500 GO:0046583 biolink:MolecularActivity monoatomic cation efflux transmembrane transporter activity Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane. go.json cation efflux permease activity|cation efflux transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0046583 GO:0046582 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046582 GO:0046581 biolink:CellularComponent intercellular canaliculus An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates. go.json http://purl.obolibrary.org/obo/GO_0046581 GO:0046580 biolink:BiologicalProcess negative regulation of Ras protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction. go.json down regulation of Ras protein signal transduction|down-regulation of Ras protein signal transduction|downregulation of Ras protein signal transduction|inhibition of Ras protein signal transduction http://purl.obolibrary.org/obo/GO_0046580 GO:1900657 biolink:BiologicalProcess positive regulation of diorcinol biosynthetic process Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process. go.json activation of diorcinol anabolism|activation of diorcinol biosynthesis|activation of diorcinol biosynthetic process|activation of diorcinol formation|activation of diorcinol synthesis|positive regulation of diorcinol anabolism|positive regulation of diorcinol biosynthesis|positive regulation of diorcinol formation|positive regulation of diorcinol synthesis|up regulation of diorcinol anabolism|up regulation of diorcinol biosynthesis|up regulation of diorcinol biosynthetic process|up regulation of diorcinol formation|up regulation of diorcinol synthesis|up-regulation of diorcinol anabolism|up-regulation of diorcinol biosynthesis|up-regulation of diorcinol biosynthetic process|up-regulation of diorcinol formation|up-regulation of diorcinol synthesis|upregulation of diorcinol anabolism|upregulation of diorcinol biosynthesis|upregulation of diorcinol biosynthetic process|upregulation of diorcinol formation|upregulation of diorcinol synthesis http://purl.obolibrary.org/obo/GO_1900657 GO:1900656 biolink:BiologicalProcess negative regulation of diorcinol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process. go.json down regulation of diorcinol anabolism|down regulation of diorcinol biosynthesis|down regulation of diorcinol biosynthetic process|down regulation of diorcinol formation|down regulation of diorcinol synthesis|down-regulation of diorcinol anabolism|down-regulation of diorcinol biosynthesis|down-regulation of diorcinol biosynthetic process|down-regulation of diorcinol formation|down-regulation of diorcinol synthesis|downregulation of diorcinol anabolism|downregulation of diorcinol biosynthesis|downregulation of diorcinol biosynthetic process|downregulation of diorcinol formation|downregulation of diorcinol synthesis|inhibition of diorcinol anabolism|inhibition of diorcinol biosynthesis|inhibition of diorcinol biosynthetic process|inhibition of diorcinol formation|inhibition of diorcinol synthesis|negative regulation of diorcinol anabolism|negative regulation of diorcinol biosynthesis|negative regulation of diorcinol formation|negative regulation of diorcinol synthesis http://purl.obolibrary.org/obo/GO_1900656 GO:1900659 biolink:BiologicalProcess negative regulation of emericellamide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process. go.json down regulation of emericellamide anabolism|down regulation of emericellamide biosynthesis|down regulation of emericellamide biosynthetic process|down regulation of emericellamide formation|down regulation of emericellamide synthesis|down-regulation of emericellamide anabolism|down-regulation of emericellamide biosynthesis|down-regulation of emericellamide biosynthetic process|down-regulation of emericellamide formation|down-regulation of emericellamide synthesis|downregulation of emericellamide anabolism|downregulation of emericellamide biosynthesis|downregulation of emericellamide biosynthetic process|downregulation of emericellamide formation|downregulation of emericellamide synthesis|inhibition of emericellamide anabolism|inhibition of emericellamide biosynthesis|inhibition of emericellamide biosynthetic process|inhibition of emericellamide formation|inhibition of emericellamide synthesis|negative regulation of emericellamide anabolism|negative regulation of emericellamide biosynthesis|negative regulation of emericellamide formation|negative regulation of emericellamide synthesis http://purl.obolibrary.org/obo/GO_1900659 GO:1900658 biolink:BiologicalProcess regulation of emericellamide biosynthetic process Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process. go.json regulation of emericellamide anabolism|regulation of emericellamide biosynthesis|regulation of emericellamide formation|regulation of emericellamide synthesis http://purl.obolibrary.org/obo/GO_1900658 GO:1900653 biolink:BiologicalProcess negative regulation of demethylkotanin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process. go.json down regulation of demethylkotanin anabolism|down regulation of demethylkotanin biosynthesis|down regulation of demethylkotanin biosynthetic process|down regulation of demethylkotanin formation|down regulation of demethylkotanin synthesis|down-regulation of demethylkotanin anabolism|down-regulation of demethylkotanin biosynthesis|down-regulation of demethylkotanin biosynthetic process|down-regulation of demethylkotanin formation|down-regulation of demethylkotanin synthesis|downregulation of demethylkotanin anabolism|downregulation of demethylkotanin biosynthesis|downregulation of demethylkotanin biosynthetic process|downregulation of demethylkotanin formation|downregulation of demethylkotanin synthesis|inhibition of demethylkotanin anabolism|inhibition of demethylkotanin biosynthesis|inhibition of demethylkotanin biosynthetic process|inhibition of demethylkotanin formation|inhibition of demethylkotanin synthesis|negative regulation of demethylkotanin anabolism|negative regulation of demethylkotanin biosynthesis|negative regulation of demethylkotanin formation|negative regulation of demethylkotanin synthesis http://purl.obolibrary.org/obo/GO_1900653 GO:1900652 biolink:BiologicalProcess regulation of demethylkotanin biosynthetic process Any process that modulates the frequency, rate or extent of demethylkotanin biosynthetic process. go.json regulation of demethylkotanin anabolism|regulation of demethylkotanin biosynthesis|regulation of demethylkotanin formation|regulation of demethylkotanin synthesis http://purl.obolibrary.org/obo/GO_1900652 GO:1900655 biolink:BiologicalProcess regulation of diorcinol biosynthetic process Any process that modulates the frequency, rate or extent of diorcinol biosynthetic process. go.json regulation of diorcinol anabolism|regulation of diorcinol biosynthesis|regulation of diorcinol formation|regulation of diorcinol synthesis http://purl.obolibrary.org/obo/GO_1900655 GO:0046589 biolink:MolecularActivity ribonuclease T1 activity Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates. EC:4.6.1.24|MetaCyc:3.1.27.3-RXN go.json Aspergillus oryzae ribonuclease activity|RNase F1|RNase G|RNase N1 activity|RNase N2 activity|RNase Sa|RNase T1|RNase T1 activity|binase activity|guanyl-specific RNase activity|guanyloribonuclease activity|ribonuclease C2|ribonuclease Ch|ribonuclease F1|ribonuclease N1|ribonuclease N3|ribonuclease PP1|ribonuclease SA|ribonuclease U1|ribonuclease guaninenucleotido-2'-transferase (cyclizing) http://purl.obolibrary.org/obo/GO_0046589 GO:1900654 biolink:BiologicalProcess positive regulation of demethylkotanin biosynthetic process Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process. go.json activation of demethylkotanin anabolism|activation of demethylkotanin biosynthesis|activation of demethylkotanin biosynthetic process|activation of demethylkotanin formation|activation of demethylkotanin synthesis|positive regulation of demethylkotanin anabolism|positive regulation of demethylkotanin biosynthesis|positive regulation of demethylkotanin formation|positive regulation of demethylkotanin synthesis|up regulation of demethylkotanin anabolism|up regulation of demethylkotanin biosynthesis|up regulation of demethylkotanin biosynthetic process|up regulation of demethylkotanin formation|up regulation of demethylkotanin synthesis|up-regulation of demethylkotanin anabolism|up-regulation of demethylkotanin biosynthesis|up-regulation of demethylkotanin biosynthetic process|up-regulation of demethylkotanin formation|up-regulation of demethylkotanin synthesis|upregulation of demethylkotanin anabolism|upregulation of demethylkotanin biosynthesis|upregulation of demethylkotanin biosynthetic process|upregulation of demethylkotanin formation|upregulation of demethylkotanin synthesis http://purl.obolibrary.org/obo/GO_1900654 GO:0046588 biolink:BiologicalProcess negative regulation of calcium-dependent cell-cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion. go.json down regulation of calcium-dependent cell-cell adhesion|down-regulation of calcium-dependent cell-cell adhesion|downregulation of calcium-dependent cell-cell adhesion|inhibition of calcium-dependent cell-cell adhesion http://purl.obolibrary.org/obo/GO_0046588 GO:0046587 biolink:BiologicalProcess positive regulation of calcium-dependent cell-cell adhesion Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion. go.json activation of calcium-dependent cell-cell adhesion|stimulation of calcium-dependent cell-cell adhesion|up regulation of calcium-dependent cell-cell adhesion|up-regulation of calcium-dependent cell-cell adhesion|upregulation of calcium-dependent cell-cell adhesion http://purl.obolibrary.org/obo/GO_0046587 GO:0046586 biolink:BiologicalProcess regulation of calcium-dependent cell-cell adhesion Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. go.json http://purl.obolibrary.org/obo/GO_0046586 GO:1900651 biolink:BiologicalProcess positive regulation of dehydroaustinol biosynthetic process Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process. go.json activation of dehydroaustinol anabolism|activation of dehydroaustinol biosynthesis|activation of dehydroaustinol biosynthetic process|activation of dehydroaustinol formation|activation of dehydroaustinol synthesis|positive regulation of dehydroaustinol anabolism|positive regulation of dehydroaustinol biosynthesis|positive regulation of dehydroaustinol formation|positive regulation of dehydroaustinol synthesis|up regulation of dehydroaustinol anabolism|up regulation of dehydroaustinol biosynthesis|up regulation of dehydroaustinol biosynthetic process|up regulation of dehydroaustinol formation|up regulation of dehydroaustinol synthesis|up-regulation of dehydroaustinol anabolism|up-regulation of dehydroaustinol biosynthesis|up-regulation of dehydroaustinol biosynthetic process|up-regulation of dehydroaustinol formation|up-regulation of dehydroaustinol synthesis|upregulation of dehydroaustinol anabolism|upregulation of dehydroaustinol biosynthesis|upregulation of dehydroaustinol biosynthetic process|upregulation of dehydroaustinol formation|upregulation of dehydroaustinol synthesis http://purl.obolibrary.org/obo/GO_1900651 GO:0046585 biolink:BiologicalProcess enniatin biosynthetic process The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. go.json enniatin anabolism|enniatin biosynthesis|enniatin formation|enniatin synthesis http://purl.obolibrary.org/obo/GO_0046585 GO:1900650 biolink:BiologicalProcess negative regulation of dehydroaustinol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process. go.json down regulation of dehydroaustinol anabolism|down regulation of dehydroaustinol biosynthesis|down regulation of dehydroaustinol biosynthetic process|down regulation of dehydroaustinol formation|down regulation of dehydroaustinol synthesis|down-regulation of dehydroaustinol anabolism|down-regulation of dehydroaustinol biosynthesis|down-regulation of dehydroaustinol biosynthetic process|down-regulation of dehydroaustinol formation|down-regulation of dehydroaustinol synthesis|downregulation of dehydroaustinol anabolism|downregulation of dehydroaustinol biosynthesis|downregulation of dehydroaustinol biosynthetic process|downregulation of dehydroaustinol formation|downregulation of dehydroaustinol synthesis|inhibition of dehydroaustinol anabolism|inhibition of dehydroaustinol biosynthesis|inhibition of dehydroaustinol biosynthetic process|inhibition of dehydroaustinol formation|inhibition of dehydroaustinol synthesis|negative regulation of dehydroaustinol anabolism|negative regulation of dehydroaustinol biosynthesis|negative regulation of dehydroaustinol formation|negative regulation of dehydroaustinol synthesis http://purl.obolibrary.org/obo/GO_1900650 GO:0046584 biolink:BiologicalProcess enniatin metabolic process The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. go.json enniatin metabolism http://purl.obolibrary.org/obo/GO_0046584 GO:0071549 biolink:BiologicalProcess cellular response to dexamethasone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. go.json http://purl.obolibrary.org/obo/GO_0071549 GO:0071548 biolink:BiologicalProcess response to dexamethasone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. go.json response to dexamethasone stimulus http://purl.obolibrary.org/obo/GO_0071548 GO:0071547 biolink:CellularComponent piP-body A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. go.json http://purl.obolibrary.org/obo/GO_0071547 GO:0071546 biolink:CellularComponent pi-body A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. go.json intermitochondrial cement http://purl.obolibrary.org/obo/GO_0071546 GO:0071545 biolink:BiologicalProcess inositol phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. go.json inositol phosphate breakdown|inositol phosphate catabolism|inositol phosphate degradation|myo-inositol phosphate catabolic process http://purl.obolibrary.org/obo/GO_0071545 GO:0071544 biolink:BiologicalProcess diphosphoinositol polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached. go.json diphosphoinositol polyphosphate breakdown|diphosphoinositol polyphosphate catabolism|diphosphoinositol polyphosphate degradation http://purl.obolibrary.org/obo/GO_0071544 GO:0071543 biolink:BiologicalProcess diphosphoinositol polyphosphate metabolic process The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached. go.json diphosphoinositol polyphosphate metabolism http://purl.obolibrary.org/obo/GO_0071543 GO:0071542 biolink:BiologicalProcess dopaminergic neuron differentiation The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. go.json http://purl.obolibrary.org/obo/GO_0071542 GO:0071541 biolink:CellularComponent eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. go.json eIF3m-containing eukaryotic translation initiation factor 3 complex http://purl.obolibrary.org/obo/GO_0071541 GO:0071540 biolink:CellularComponent eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. go.json eIF3e-containing eukaryotic translation initiation factor 3 complex http://purl.obolibrary.org/obo/GO_0071540 GO:0046594 biolink:BiologicalProcess maintenance of pole plasm mRNA location The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster. go.json maintenance of oocyte pole plasm mRNA localization|maintenance of pole plasm mRNA localization http://purl.obolibrary.org/obo/GO_0046594 GO:0046593 biolink:MolecularActivity mandelonitrile lyase activity Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde. EC:4.1.2.10|MetaCyc:MANDELONITRILE-LYASE-RXN|RHEA:18313 go.json (R)-oxynitrilase activity|D-alpha-hydroxynitrile lyase activity|D-oxynitrilase activity|hydroxynitrile lyase activity|mandelonitrile benzaldehyde-lyase (cyanide-forming)|mandelonitrile benzaldehyde-lyase activity http://purl.obolibrary.org/obo/GO_0046593 GO:0046592 biolink:MolecularActivity polyamine oxidase activity Catalysis of the oxidative degradation or interconversion of polyamines. go.json 1-N-acetylspermidine:oxygen oxidoreductase (deaminating)|N1-acetylspermidine:oxygen oxidoreductase (deaminating) http://purl.obolibrary.org/obo/GO_0046592 GO:0046591 biolink:BiologicalProcess obsolete embryonic leg joint morphogenesis OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. go.json embryonic leg joint morphogenesis True http://purl.obolibrary.org/obo/GO_0046591 GO:1900668 biolink:BiologicalProcess negative regulation of endocrocin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process. go.json down regulation of endocrocin anabolism|down regulation of endocrocin biosynthesis|down regulation of endocrocin biosynthetic process|down regulation of endocrocin formation|down regulation of endocrocin synthesis|down-regulation of endocrocin anabolism|down-regulation of endocrocin biosynthesis|down-regulation of endocrocin biosynthetic process|down-regulation of endocrocin formation|down-regulation of endocrocin synthesis|downregulation of endocrocin anabolism|downregulation of endocrocin biosynthesis|downregulation of endocrocin biosynthetic process|downregulation of endocrocin formation|downregulation of endocrocin synthesis|inhibition of endocrocin anabolism|inhibition of endocrocin biosynthesis|inhibition of endocrocin biosynthetic process|inhibition of endocrocin formation|inhibition of endocrocin synthesis|negative regulation of endocrocin anabolism|negative regulation of endocrocin biosynthesis|negative regulation of endocrocin formation|negative regulation of endocrocin synthesis http://purl.obolibrary.org/obo/GO_1900668 GO:0046590 biolink:BiologicalProcess obsolete embryonic leg morphogenesis OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. A leg is a limb on which an animal walks and stands. go.json embryonic leg morphogenesis True http://purl.obolibrary.org/obo/GO_0046590 GO:1900667 biolink:BiologicalProcess regulation of endocrocin biosynthetic process Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process. go.json regulation of endocrocin anabolism|regulation of endocrocin biosynthesis|regulation of endocrocin formation|regulation of endocrocin synthesis http://purl.obolibrary.org/obo/GO_1900667 GO:1900669 biolink:BiologicalProcess positive regulation of endocrocin biosynthetic process Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process. go.json activation of endocrocin anabolism|activation of endocrocin biosynthesis|activation of endocrocin biosynthetic process|activation of endocrocin formation|activation of endocrocin synthesis|positive regulation of endocrocin anabolism|positive regulation of endocrocin biosynthesis|positive regulation of endocrocin formation|positive regulation of endocrocin synthesis|up regulation of endocrocin anabolism|up regulation of endocrocin biosynthesis|up regulation of endocrocin biosynthetic process|up regulation of endocrocin formation|up regulation of endocrocin synthesis|up-regulation of endocrocin anabolism|up-regulation of endocrocin biosynthesis|up-regulation of endocrocin biosynthetic process|up-regulation of endocrocin formation|up-regulation of endocrocin synthesis|upregulation of endocrocin anabolism|upregulation of endocrocin biosynthesis|upregulation of endocrocin biosynthetic process|upregulation of endocrocin formation|upregulation of endocrocin synthesis http://purl.obolibrary.org/obo/GO_1900669 GO:1900664 biolink:BiologicalProcess regulation of emodin biosynthetic process Any process that modulates the frequency, rate or extent of emodin biosynthetic process. go.json regulation of emodin anabolism|regulation of emodin biosynthesis|regulation of emodin formation|regulation of emodin synthesis http://purl.obolibrary.org/obo/GO_1900664 GO:1900663 biolink:BiologicalProcess positive regulation of emericellamide A biosynthetic process Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process. go.json activation of emericellamide A anabolism|activation of emericellamide A biosynthesis|activation of emericellamide A biosynthetic process|activation of emericellamide A formation|activation of emericellamide A synthesis|positive regulation of emericellamide A anabolism|positive regulation of emericellamide A biosynthesis|positive regulation of emericellamide A formation|positive regulation of emericellamide A synthesis|up regulation of emericellamide A anabolism|up regulation of emericellamide A biosynthesis|up regulation of emericellamide A biosynthetic process|up regulation of emericellamide A formation|up regulation of emericellamide A synthesis|up-regulation of emericellamide A anabolism|up-regulation of emericellamide A biosynthesis|up-regulation of emericellamide A biosynthetic process|up-regulation of emericellamide A formation|up-regulation of emericellamide A synthesis|upregulation of emericellamide A anabolism|upregulation of emericellamide A biosynthesis|upregulation of emericellamide A biosynthetic process|upregulation of emericellamide A formation|upregulation of emericellamide A synthesis http://purl.obolibrary.org/obo/GO_1900663 GO:1900666 biolink:BiologicalProcess positive regulation of emodin biosynthetic process Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process. go.json activation of emodin anabolism|activation of emodin biosynthesis|activation of emodin biosynthetic process|activation of emodin formation|activation of emodin synthesis|positive regulation of emodin anabolism|positive regulation of emodin biosynthesis|positive regulation of emodin formation|positive regulation of emodin synthesis|up regulation of emodin anabolism|up regulation of emodin biosynthesis|up regulation of emodin biosynthetic process|up regulation of emodin formation|up regulation of emodin synthesis|up-regulation of emodin anabolism|up-regulation of emodin biosynthesis|up-regulation of emodin biosynthetic process|up-regulation of emodin formation|up-regulation of emodin synthesis|upregulation of emodin anabolism|upregulation of emodin biosynthesis|upregulation of emodin biosynthetic process|upregulation of emodin formation|upregulation of emodin synthesis http://purl.obolibrary.org/obo/GO_1900666 GO:1900665 biolink:BiologicalProcess negative regulation of emodin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process. go.json down regulation of emodin anabolism|down regulation of emodin biosynthesis|down regulation of emodin biosynthetic process|down regulation of emodin formation|down regulation of emodin synthesis|down-regulation of emodin anabolism|down-regulation of emodin biosynthesis|down-regulation of emodin biosynthetic process|down-regulation of emodin formation|down-regulation of emodin synthesis|downregulation of emodin anabolism|downregulation of emodin biosynthesis|downregulation of emodin biosynthetic process|downregulation of emodin formation|downregulation of emodin synthesis|inhibition of emodin anabolism|inhibition of emodin biosynthesis|inhibition of emodin biosynthetic process|inhibition of emodin formation|inhibition of emodin synthesis|negative regulation of emodin anabolism|negative regulation of emodin biosynthesis|negative regulation of emodin formation|negative regulation of emodin synthesis http://purl.obolibrary.org/obo/GO_1900665 GO:0046599 biolink:BiologicalProcess regulation of centriole replication Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. go.json http://purl.obolibrary.org/obo/GO_0046599 GO:1900660 biolink:BiologicalProcess positive regulation of emericellamide biosynthetic process Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process. go.json activation of emericellamide anabolism|activation of emericellamide biosynthesis|activation of emericellamide biosynthetic process|activation of emericellamide formation|activation of emericellamide synthesis|positive regulation of emericellamide anabolism|positive regulation of emericellamide biosynthesis|positive regulation of emericellamide formation|positive regulation of emericellamide synthesis|up regulation of emericellamide anabolism|up regulation of emericellamide biosynthesis|up regulation of emericellamide biosynthetic process|up regulation of emericellamide formation|up regulation of emericellamide synthesis|up-regulation of emericellamide anabolism|up-regulation of emericellamide biosynthesis|up-regulation of emericellamide biosynthetic process|up-regulation of emericellamide formation|up-regulation of emericellamide synthesis|upregulation of emericellamide anabolism|upregulation of emericellamide biosynthesis|upregulation of emericellamide biosynthetic process|upregulation of emericellamide formation|upregulation of emericellamide synthesis http://purl.obolibrary.org/obo/GO_1900660 GO:0046598 biolink:BiologicalProcess positive regulation of viral entry into host cell Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. go.json positive regulation of viral penetration into host cell http://purl.obolibrary.org/obo/GO_0046598 GO:0046597 biolink:BiologicalProcess negative regulation of viral entry into host cell Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. go.json negative regulation of viral penetration into host cell http://purl.obolibrary.org/obo/GO_0046597 GO:1900662 biolink:BiologicalProcess negative regulation of emericellamide A biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process. go.json down regulation of emericellamide A anabolism|down regulation of emericellamide A biosynthesis|down regulation of emericellamide A biosynthetic process|down regulation of emericellamide A formation|down regulation of emericellamide A synthesis|down-regulation of emericellamide A anabolism|down-regulation of emericellamide A biosynthesis|down-regulation of emericellamide A biosynthetic process|down-regulation of emericellamide A formation|down-regulation of emericellamide A synthesis|downregulation of emericellamide A anabolism|downregulation of emericellamide A biosynthesis|downregulation of emericellamide A biosynthetic process|downregulation of emericellamide A formation|downregulation of emericellamide A synthesis|inhibition of emericellamide A anabolism|inhibition of emericellamide A biosynthesis|inhibition of emericellamide A biosynthetic process|inhibition of emericellamide A formation|inhibition of emericellamide A synthesis|negative regulation of emericellamide A anabolism|negative regulation of emericellamide A biosynthesis|negative regulation of emericellamide A formation|negative regulation of emericellamide A synthesis http://purl.obolibrary.org/obo/GO_1900662 GO:0046596 biolink:BiologicalProcess regulation of viral entry into host cell Any process that modulates the frequency, rate or extent of the viral entry into the host cell. go.json regulation of viral penetration into host cell|viral escort protein http://purl.obolibrary.org/obo/GO_0046596 GO:1900661 biolink:BiologicalProcess regulation of emericellamide A biosynthetic process Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process. go.json regulation of emericellamide A anabolism|regulation of emericellamide A biosynthesis|regulation of emericellamide A formation|regulation of emericellamide A synthesis http://purl.obolibrary.org/obo/GO_1900661 GO:0046595 biolink:BiologicalProcess establishment of pole plasm mRNA localization Any process that results in the directed movement of mRNA to the oocyte pole plasm. go.json establishment of oocyte pole plasm mRNA localization|establishment of pole plasm mRNA localisation http://purl.obolibrary.org/obo/GO_0046595 GO:0071539 biolink:BiologicalProcess protein localization to centrosome A process in which a protein is transported to, or maintained at, the centrosome. go.json protein localisation to centrosome http://purl.obolibrary.org/obo/GO_0071539 GO:0071538 biolink:BiologicalProcess obsolete SH2 domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction. go.json True http://purl.obolibrary.org/obo/GO_0071538 GO:0071537 biolink:BiologicalProcess obsolete C3HC4-type RING finger domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction. go.json zinc finger C3HC4 type domain-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071537 GO:0071536 biolink:BiologicalProcess obsolete RING-like zinc finger domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction. go.json RING-like domain-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071536 GO:0071535 biolink:MolecularActivity RING-like zinc finger domain binding Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain. go.json http://purl.obolibrary.org/obo/GO_0071535 GO:0071534 biolink:BiologicalProcess obsolete zf-TRAF domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction. go.json TRAF-type zinc finger domain-mediated complex assembly|zinc finger TRAF-type domain-mediated complex assembly|zinc-finger-TRAF domain-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071534 GO:0071533 biolink:BiologicalProcess obsolete ankyrin repeat-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction. go.json ANK repeat-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071533 GO:0071532 biolink:MolecularActivity ankyrin repeat binding Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. go.json ANK repeat binding http://purl.obolibrary.org/obo/GO_0071532 GO:0071531 biolink:BiologicalProcess obsolete Rel homology domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a Rel homology domain (RHD) interaction. go.json RHD domain-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071531 GO:0071530 biolink:BiologicalProcess obsolete FHA domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction. go.json forkhead-associated domain-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071530 GO:0071561 biolink:CellularComponent nucleus-vacuole junction An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. go.json NV junction|NVJ|nucleus-vacuole membrane contact site http://purl.obolibrary.org/obo/GO_0071561 GO:0071560 biolink:BiologicalProcess cellular response to transforming growth factor beta stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. go.json cellular response to TGF-beta stimulus|cellular response to TGFbeta stimulus http://purl.obolibrary.org/obo/GO_0071560 GO:1900679 biolink:BiologicalProcess negative regulation of ferricrocin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process. go.json down regulation of ferricrocin anabolism|down regulation of ferricrocin biosynthesis|down regulation of ferricrocin biosynthetic process|down regulation of ferricrocin biosynthetic process, peptide formation|down regulation of ferricrocin biosynthetic process, peptide modification|down regulation of ferricrocin formation|down regulation of ferricrocin synthesis|down-regulation of ferricrocin anabolism|down-regulation of ferricrocin biosynthesis|down-regulation of ferricrocin biosynthetic process|down-regulation of ferricrocin biosynthetic process, peptide formation|down-regulation of ferricrocin biosynthetic process, peptide modification|down-regulation of ferricrocin formation|down-regulation of ferricrocin synthesis|downregulation of ferricrocin anabolism|downregulation of ferricrocin biosynthesis|downregulation of ferricrocin biosynthetic process|downregulation of ferricrocin biosynthetic process, peptide formation|downregulation of ferricrocin biosynthetic process, peptide modification|downregulation of ferricrocin formation|downregulation of ferricrocin synthesis|inhibition of ferricrocin anabolism|inhibition of ferricrocin biosynthesis|inhibition of ferricrocin biosynthetic process|inhibition of ferricrocin biosynthetic process, peptide formation|inhibition of ferricrocin biosynthetic process, peptide modification|inhibition of ferricrocin formation|inhibition of ferricrocin synthesis|negative regulation of ferricrocin anabolism|negative regulation of ferricrocin biosynthesis|negative regulation of ferricrocin biosynthetic process, peptide formation|negative regulation of ferricrocin biosynthetic process, peptide modification|negative regulation of ferricrocin formation|negative regulation of ferricrocin synthesis http://purl.obolibrary.org/obo/GO_1900679 GO:1900678 biolink:BiologicalProcess regulation of ferricrocin biosynthetic process Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process. go.json regulation of ferricrocin anabolism|regulation of ferricrocin biosynthesis|regulation of ferricrocin biosynthetic process, peptide formation|regulation of ferricrocin biosynthetic process, peptide modification|regulation of ferricrocin formation|regulation of ferricrocin synthesis http://purl.obolibrary.org/obo/GO_1900678 GO:1900675 biolink:BiologicalProcess regulation of F-9775B biosynthetic process Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process. go.json regulation of F-9775B anabolism|regulation of F-9775B biosynthesis|regulation of F-9775B formation|regulation of F-9775B synthesis http://purl.obolibrary.org/obo/GO_1900675 GO:1900674 biolink:BiologicalProcess olefin biosynthetic process The chemical reactions and pathways resulting in the formation of olefin. go.json olefin anabolism|olefin biosynthesis|olefin formation|olefin synthesis http://purl.obolibrary.org/obo/GO_1900674 GO:1900677 biolink:BiologicalProcess positive regulation of F-9775B biosynthetic process Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process. go.json activation of F-9775B anabolism|activation of F-9775B biosynthesis|activation of F-9775B biosynthetic process|activation of F-9775B formation|activation of F-9775B synthesis|positive regulation of F-9775B anabolism|positive regulation of F-9775B biosynthesis|positive regulation of F-9775B formation|positive regulation of F-9775B synthesis|up regulation of F-9775B anabolism|up regulation of F-9775B biosynthesis|up regulation of F-9775B biosynthetic process|up regulation of F-9775B formation|up regulation of F-9775B synthesis|up-regulation of F-9775B anabolism|up-regulation of F-9775B biosynthesis|up-regulation of F-9775B biosynthetic process|up-regulation of F-9775B formation|up-regulation of F-9775B synthesis|upregulation of F-9775B anabolism|upregulation of F-9775B biosynthesis|upregulation of F-9775B biosynthetic process|upregulation of F-9775B formation|upregulation of F-9775B synthesis http://purl.obolibrary.org/obo/GO_1900677 GO:1900676 biolink:BiologicalProcess negative regulation of F-9775B biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process. go.json down regulation of F-9775B anabolism|down regulation of F-9775B biosynthesis|down regulation of F-9775B biosynthetic process|down regulation of F-9775B formation|down regulation of F-9775B synthesis|down-regulation of F-9775B anabolism|down-regulation of F-9775B biosynthesis|down-regulation of F-9775B biosynthetic process|down-regulation of F-9775B formation|down-regulation of F-9775B synthesis|downregulation of F-9775B anabolism|downregulation of F-9775B biosynthesis|downregulation of F-9775B biosynthetic process|downregulation of F-9775B formation|downregulation of F-9775B synthesis|inhibition of F-9775B anabolism|inhibition of F-9775B biosynthesis|inhibition of F-9775B biosynthetic process|inhibition of F-9775B formation|inhibition of F-9775B synthesis|negative regulation of F-9775B anabolism|negative regulation of F-9775B biosynthesis|negative regulation of F-9775B formation|negative regulation of F-9775B synthesis http://purl.obolibrary.org/obo/GO_1900676 GO:1900671 biolink:BiologicalProcess negative regulation of F-9775A biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process. go.json down regulation of F-9775A anabolism|down regulation of F-9775A biosynthesis|down regulation of F-9775A biosynthetic process|down regulation of F-9775A formation|down regulation of F-9775A synthesis|down-regulation of F-9775A anabolism|down-regulation of F-9775A biosynthesis|down-regulation of F-9775A biosynthetic process|down-regulation of F-9775A formation|down-regulation of F-9775A synthesis|downregulation of F-9775A anabolism|downregulation of F-9775A biosynthesis|downregulation of F-9775A biosynthetic process|downregulation of F-9775A formation|downregulation of F-9775A synthesis|inhibition of F-9775A anabolism|inhibition of F-9775A biosynthesis|inhibition of F-9775A biosynthetic process|inhibition of F-9775A formation|inhibition of F-9775A synthesis|negative regulation of F-9775A anabolism|negative regulation of F-9775A biosynthesis|negative regulation of F-9775A formation|negative regulation of F-9775A synthesis http://purl.obolibrary.org/obo/GO_1900671 GO:1900670 biolink:BiologicalProcess regulation of F-9775A biosynthetic process Any process that modulates the frequency, rate or extent of F-9775A biosynthetic process. go.json regulation of F-9775A anabolism|regulation of F-9775A biosynthesis|regulation of F-9775A formation|regulation of F-9775A synthesis http://purl.obolibrary.org/obo/GO_1900670 GO:1900673 biolink:BiologicalProcess olefin metabolic process The chemical reactions and pathways involving olefin. go.json olefin metabolism http://purl.obolibrary.org/obo/GO_1900673 GO:1900672 biolink:BiologicalProcess positive regulation of F-9775A biosynthetic process Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process. go.json activation of F-9775A anabolism|activation of F-9775A biosynthesis|activation of F-9775A biosynthetic process|activation of F-9775A formation|activation of F-9775A synthesis|positive regulation of F-9775A anabolism|positive regulation of F-9775A biosynthesis|positive regulation of F-9775A formation|positive regulation of F-9775A synthesis|up regulation of F-9775A anabolism|up regulation of F-9775A biosynthesis|up regulation of F-9775A biosynthetic process|up regulation of F-9775A formation|up regulation of F-9775A synthesis|up-regulation of F-9775A anabolism|up-regulation of F-9775A biosynthesis|up-regulation of F-9775A biosynthetic process|up-regulation of F-9775A formation|up-regulation of F-9775A synthesis|upregulation of F-9775A anabolism|upregulation of F-9775A biosynthesis|upregulation of F-9775A biosynthetic process|upregulation of F-9775A formation|upregulation of F-9775A synthesis http://purl.obolibrary.org/obo/GO_1900672 GO:1900680 biolink:BiologicalProcess positive regulation of ferricrocin biosynthetic process Any process that activates or increases the frequency, rate or extent of ferricrocin biosynthetic process. go.json activation of ferricrocin anabolism|activation of ferricrocin biosynthesis|activation of ferricrocin biosynthetic process|activation of ferricrocin biosynthetic process, peptide formation|activation of ferricrocin biosynthetic process, peptide modification|activation of ferricrocin formation|activation of ferricrocin synthesis|positive regulation of ferricrocin anabolism|positive regulation of ferricrocin biosynthesis|positive regulation of ferricrocin biosynthetic process, peptide formation|positive regulation of ferricrocin biosynthetic process, peptide modification|positive regulation of ferricrocin formation|positive regulation of ferricrocin synthesis|up regulation of ferricrocin anabolism|up regulation of ferricrocin biosynthesis|up regulation of ferricrocin biosynthetic process|up regulation of ferricrocin biosynthetic process, peptide formation|up regulation of ferricrocin biosynthetic process, peptide modification|up regulation of ferricrocin formation|up regulation of ferricrocin synthesis|up-regulation of ferricrocin anabolism|up-regulation of ferricrocin biosynthesis|up-regulation of ferricrocin biosynthetic process|up-regulation of ferricrocin biosynthetic process, peptide formation|up-regulation of ferricrocin biosynthetic process, peptide modification|up-regulation of ferricrocin formation|up-regulation of ferricrocin synthesis|upregulation of ferricrocin anabolism|upregulation of ferricrocin biosynthesis|upregulation of ferricrocin biosynthetic process|upregulation of ferricrocin biosynthetic process, peptide formation|upregulation of ferricrocin biosynthetic process, peptide modification|upregulation of ferricrocin formation|upregulation of ferricrocin synthesis http://purl.obolibrary.org/obo/GO_1900680 GO:0071569 biolink:BiologicalProcess protein ufmylation Covalent attachment of the ubiquitin-like protein UFM1 to another protein. go.json http://purl.obolibrary.org/obo/GO_0071569 GO:0071568 biolink:MolecularActivity UFM1 transferase activity Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages. go.json http://purl.obolibrary.org/obo/GO_0071568 GO:0071567 biolink:MolecularActivity deUFMylase activity A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated. go.json UFM1 hydrolase activity http://purl.obolibrary.org/obo/GO_0071567 GO:0071566 biolink:MolecularActivity UFM1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond. go.json http://purl.obolibrary.org/obo/GO_0071566 GO:0071565 biolink:CellularComponent nBAF complex A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. go.json http://purl.obolibrary.org/obo/GO_0071565 GO:0071564 biolink:CellularComponent npBAF complex A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. go.json http://purl.obolibrary.org/obo/GO_0071564 GO:0071563 biolink:CellularComponent Myo2p-Vac17p-Vac8p transport complex A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p. go.json http://purl.obolibrary.org/obo/GO_0071563 GO:0071562 biolink:BiologicalProcess nucleus-vacuole junction assembly The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction (NVJ), membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. The NVJ plays roles in piecemeal microautophagy of the nucleus and in the cytoplasm-to-vacuole targeting pathway. go.json NV junction assembly|NV junction formation|NVJ assembly|NVJ formation|nucleus-vacuole junction formation http://purl.obolibrary.org/obo/GO_0071562 GO:0071550 biolink:BiologicalProcess death-inducing signaling complex assembly A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway. go.json DD-mediated complex assembly|DISC assembly|DISC formation|death domain-mediated complex assembly|death domain-mediated complex assembly involved in extrinsic apoptotic pathway|death-inducing signaling complex formation|death-inducing signalling complex assembly http://purl.obolibrary.org/obo/GO_0071550 GO:1900689 biolink:BiologicalProcess regulation of gliotoxin biosynthetic process Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process. go.json regulation of gliotoxin anabolism|regulation of gliotoxin biosynthesis|regulation of gliotoxin formation|regulation of gliotoxin synthesis http://purl.obolibrary.org/obo/GO_1900689 GO:1900686 biolink:BiologicalProcess regulation of gerfelin biosynthetic process Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process. go.json regulation of gerfelin anabolism|regulation of gerfelin biosynthesis|regulation of gerfelin formation|regulation of gerfelin synthesis http://purl.obolibrary.org/obo/GO_1900686 GO:1900685 biolink:BiologicalProcess positive regulation of fumonisin biosynthetic process Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process. go.json activation of fumonisin anabolism|activation of fumonisin biosynthesis|activation of fumonisin biosynthetic process|activation of fumonisin formation|activation of fumonisin synthesis|positive regulation of fumonisin anabolism|positive regulation of fumonisin biosynthesis|positive regulation of fumonisin formation|positive regulation of fumonisin synthesis|up regulation of fumonisin anabolism|up regulation of fumonisin biosynthesis|up regulation of fumonisin biosynthetic process|up regulation of fumonisin formation|up regulation of fumonisin synthesis|up-regulation of fumonisin anabolism|up-regulation of fumonisin biosynthesis|up-regulation of fumonisin biosynthetic process|up-regulation of fumonisin formation|up-regulation of fumonisin synthesis|upregulation of fumonisin anabolism|upregulation of fumonisin biosynthesis|upregulation of fumonisin biosynthetic process|upregulation of fumonisin formation|upregulation of fumonisin synthesis http://purl.obolibrary.org/obo/GO_1900685 GO:1900688 biolink:BiologicalProcess positive regulation of gerfelin biosynthetic process Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process. go.json activation of gerfelin anabolism|activation of gerfelin biosynthesis|activation of gerfelin biosynthetic process|activation of gerfelin formation|activation of gerfelin synthesis|positive regulation of gerfelin anabolism|positive regulation of gerfelin biosynthesis|positive regulation of gerfelin formation|positive regulation of gerfelin synthesis|up regulation of gerfelin anabolism|up regulation of gerfelin biosynthesis|up regulation of gerfelin biosynthetic process|up regulation of gerfelin formation|up regulation of gerfelin synthesis|up-regulation of gerfelin anabolism|up-regulation of gerfelin biosynthesis|up-regulation of gerfelin biosynthetic process|up-regulation of gerfelin formation|up-regulation of gerfelin synthesis|upregulation of gerfelin anabolism|upregulation of gerfelin biosynthesis|upregulation of gerfelin biosynthetic process|upregulation of gerfelin formation|upregulation of gerfelin synthesis http://purl.obolibrary.org/obo/GO_1900688 GO:1900687 biolink:BiologicalProcess negative regulation of gerfelin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process. go.json down regulation of gerfelin anabolism|down regulation of gerfelin biosynthesis|down regulation of gerfelin biosynthetic process|down regulation of gerfelin formation|down regulation of gerfelin synthesis|down-regulation of gerfelin anabolism|down-regulation of gerfelin biosynthesis|down-regulation of gerfelin biosynthetic process|down-regulation of gerfelin formation|down-regulation of gerfelin synthesis|downregulation of gerfelin anabolism|downregulation of gerfelin biosynthesis|downregulation of gerfelin biosynthetic process|downregulation of gerfelin formation|downregulation of gerfelin synthesis|inhibition of gerfelin anabolism|inhibition of gerfelin biosynthesis|inhibition of gerfelin biosynthetic process|inhibition of gerfelin formation|inhibition of gerfelin synthesis|negative regulation of gerfelin anabolism|negative regulation of gerfelin biosynthesis|negative regulation of gerfelin formation|negative regulation of gerfelin synthesis http://purl.obolibrary.org/obo/GO_1900687 GO:1900682 biolink:BiologicalProcess octadecene biosynthetic process The chemical reactions and pathways resulting in the formation of octadecene. go.json 1-octadecene biosynthetic process|octadecene anabolism|octadecene biosynthesis|octadecene formation|octadecene synthesis http://purl.obolibrary.org/obo/GO_1900682 GO:1900681 biolink:BiologicalProcess octadecene metabolic process The chemical reactions and pathways involving octadecene. go.json octadecene metabolism http://purl.obolibrary.org/obo/GO_1900681 GO:1900684 biolink:BiologicalProcess negative regulation of fumonisin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of fumonisin biosynthetic process. go.json down regulation of fumonisin anabolism|down regulation of fumonisin biosynthesis|down regulation of fumonisin biosynthetic process|down regulation of fumonisin formation|down regulation of fumonisin synthesis|down-regulation of fumonisin anabolism|down-regulation of fumonisin biosynthesis|down-regulation of fumonisin biosynthetic process|down-regulation of fumonisin formation|down-regulation of fumonisin synthesis|downregulation of fumonisin anabolism|downregulation of fumonisin biosynthesis|downregulation of fumonisin biosynthetic process|downregulation of fumonisin formation|downregulation of fumonisin synthesis|inhibition of fumonisin anabolism|inhibition of fumonisin biosynthesis|inhibition of fumonisin biosynthetic process|inhibition of fumonisin formation|inhibition of fumonisin synthesis|negative regulation of fumonisin anabolism|negative regulation of fumonisin biosynthesis|negative regulation of fumonisin formation|negative regulation of fumonisin synthesis http://purl.obolibrary.org/obo/GO_1900684 GO:1900683 biolink:BiologicalProcess regulation of fumonisin biosynthetic process Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process. go.json regulation of fumonisin anabolism|regulation of fumonisin biosynthesis|regulation of fumonisin formation|regulation of fumonisin synthesis http://purl.obolibrary.org/obo/GO_1900683 GO:1900691 biolink:BiologicalProcess positive regulation of gliotoxin biosynthetic process Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process. go.json activation of gliotoxin anabolism|activation of gliotoxin biosynthesis|activation of gliotoxin biosynthetic process|activation of gliotoxin formation|activation of gliotoxin synthesis|positive regulation of gliotoxin anabolism|positive regulation of gliotoxin biosynthesis|positive regulation of gliotoxin formation|positive regulation of gliotoxin synthesis|up regulation of gliotoxin anabolism|up regulation of gliotoxin biosynthesis|up regulation of gliotoxin biosynthetic process|up regulation of gliotoxin formation|up regulation of gliotoxin synthesis|up-regulation of gliotoxin anabolism|up-regulation of gliotoxin biosynthesis|up-regulation of gliotoxin biosynthetic process|up-regulation of gliotoxin formation|up-regulation of gliotoxin synthesis|upregulation of gliotoxin anabolism|upregulation of gliotoxin biosynthesis|upregulation of gliotoxin biosynthetic process|upregulation of gliotoxin formation|upregulation of gliotoxin synthesis http://purl.obolibrary.org/obo/GO_1900691 GO:1900690 biolink:BiologicalProcess negative regulation of gliotoxin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process. go.json down regulation of gliotoxin anabolism|down regulation of gliotoxin biosynthesis|down regulation of gliotoxin biosynthetic process|down regulation of gliotoxin formation|down regulation of gliotoxin synthesis|down-regulation of gliotoxin anabolism|down-regulation of gliotoxin biosynthesis|down-regulation of gliotoxin biosynthetic process|down-regulation of gliotoxin formation|down-regulation of gliotoxin synthesis|downregulation of gliotoxin anabolism|downregulation of gliotoxin biosynthesis|downregulation of gliotoxin biosynthetic process|downregulation of gliotoxin formation|downregulation of gliotoxin synthesis|inhibition of gliotoxin anabolism|inhibition of gliotoxin biosynthesis|inhibition of gliotoxin biosynthetic process|inhibition of gliotoxin formation|inhibition of gliotoxin synthesis|negative regulation of gliotoxin anabolism|negative regulation of gliotoxin biosynthesis|negative regulation of gliotoxin formation|negative regulation of gliotoxin synthesis http://purl.obolibrary.org/obo/GO_1900690 GO:0071559 biolink:BiologicalProcess response to transforming growth factor beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. go.json response to TGF-beta stimulus|response to TGFbeta stimulus|response to transforming growth factor beta stimulus http://purl.obolibrary.org/obo/GO_0071559 GO:0071558 biolink:MolecularActivity histone H3K27me2/H3K27me3 demethylase activity Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. EC:1.14.11.68|RHEA:60224|Reactome:R-HSA-3222593|Reactome:R-HSA-5617431|Reactome:R-HSA-5617887|Reactome:R-HSA-9822914|Reactome:R-HSA-9822985 go.json histone H3-tri/di-methyl-lysine-27 demethylase activity|histone H3K27me2 demethylase activity|histone H3K27me3 demethylase activity|histone demethylase activity (H3-K27 specific) http://purl.obolibrary.org/obo/GO_0071558 GO:0071557 biolink:BiologicalProcess histone H3-K27 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone. go.json H3K27 demethylation http://purl.obolibrary.org/obo/GO_0071557 gocheck_do_not_annotate GO:0071556 biolink:CellularComponent obsolete integral component of lumenal side of endoplasmic reticulum membrane OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane. go.json integral to ER membrane, lumenal side|integral to lumenal leaflet of endoplasmic reticulum membrane|integral to lumenal side of ER membrane|integral to lumenal side of endoplasmic reticulum membrane True http://purl.obolibrary.org/obo/GO_0071556 GO:0071555 biolink:BiologicalProcess cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. go.json cell wall organisation|cell wall organisation in other organism|cell wall organization and biogenesis|cell wall organization at cellular level|cell wall organization in other organism|cellular cell wall organisation|cellular cell wall organization http://purl.obolibrary.org/obo/GO_0071555 goslim_candida|goslim_pir GO:0071554 biolink:BiologicalProcess cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall. go.json cell wall organisation or biogenesis|cell wall organization or biogenesis at cellular level|cellular cell wall organisation or biogenesis|cellular cell wall organization or biogenesis http://purl.obolibrary.org/obo/GO_0071554 goslim_chembl|goslim_generic|goslim_pombe|goslim_yeast|prokaryote_subset GO:0071553 biolink:MolecularActivity G protein-coupled pyrimidinergic nucleotide receptor activity Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. go.json G protein coupled pyrimidinergic nucleotide receptor activity|G-protein coupled pyrimidinergic nucleotide receptor activity|pyrimidinergic nucleotide receptor activity, G protein coupled|pyrimidinergic nucleotide receptor activity, G-protein coupled http://purl.obolibrary.org/obo/GO_0071553 GO:0071552 biolink:BiologicalProcess obsolete RIP homotypic interaction motif-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction. go.json RHIM-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071552 GO:0071551 biolink:MolecularActivity RIP homotypic interaction motif binding Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases. go.json RHIM binding http://purl.obolibrary.org/obo/GO_0071551 GO:0071583 biolink:BiologicalProcess negative regulation of zinc ion transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other. go.json negative regulation of zinc ion membrane transport http://purl.obolibrary.org/obo/GO_0071583 GO:0071582 biolink:BiologicalProcess negative regulation of zinc ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0071582 GO:0071581 biolink:BiologicalProcess regulation of zinc ion transmembrane import Any process that modulates the frequency, rate or extent of zinc ion import. go.json http://purl.obolibrary.org/obo/GO_0071581 GO:0071580 biolink:BiologicalProcess regulation of zinc ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other. go.json regulation of zinc ion membrane transport http://purl.obolibrary.org/obo/GO_0071580 GO:1900697 biolink:BiologicalProcess positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process. go.json activation of N',N'',N'''-triacetylfusarinine C anabolism|activation of N',N'',N'''-triacetylfusarinine C biosynthesis|activation of N',N'',N'''-triacetylfusarinine C biosynthetic process|activation of N',N'',N'''-triacetylfusarinine C formation|activation of N',N'',N'''-triacetylfusarinine C synthesis|positive regulation of N',N'',N'''-triacetylfusarinine C anabolism|positive regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|positive regulation of N',N'',N'''-triacetylfusarinine C formation|positive regulation of N',N'',N'''-triacetylfusarinine C synthesis|up regulation of N',N'',N'''-triacetylfusarinine C anabolism|up regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|up regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process|up regulation of N',N'',N'''-triacetylfusarinine C formation|up regulation of N',N'',N'''-triacetylfusarinine C synthesis|up-regulation of N',N'',N'''-triacetylfusarinine C anabolism|up-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|up-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process|up-regulation of N',N'',N'''-triacetylfusarinine C formation|up-regulation of N',N'',N'''-triacetylfusarinine C synthesis|upregulation of N',N'',N'''-triacetylfusarinine C anabolism|upregulation of N',N'',N'''-triacetylfusarinine C biosynthesis|upregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process|upregulation of N',N'',N'''-triacetylfusarinine C formation|upregulation of N',N'',N'''-triacetylfusarinine C synthesis http://purl.obolibrary.org/obo/GO_1900697 GO:1900696 biolink:BiologicalProcess negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process. go.json down regulation of N',N'',N'''-triacetylfusarinine C anabolism|down regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|down regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process|down regulation of N',N'',N'''-triacetylfusarinine C formation|down regulation of N',N'',N'''-triacetylfusarinine C synthesis|down-regulation of N',N'',N'''-triacetylfusarinine C anabolism|down-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|down-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process|down-regulation of N',N'',N'''-triacetylfusarinine C formation|down-regulation of N',N'',N'''-triacetylfusarinine C synthesis|downregulation of N',N'',N'''-triacetylfusarinine C anabolism|downregulation of N',N'',N'''-triacetylfusarinine C biosynthesis|downregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process|downregulation of N',N'',N'''-triacetylfusarinine C formation|downregulation of N',N'',N'''-triacetylfusarinine C synthesis|inhibition of N',N'',N'''-triacetylfusarinine C anabolism|inhibition of N',N'',N'''-triacetylfusarinine C biosynthesis|inhibition of N',N'',N'''-triacetylfusarinine C biosynthetic process|inhibition of N',N'',N'''-triacetylfusarinine C formation|inhibition of N',N'',N'''-triacetylfusarinine C synthesis|negative regulation of N',N'',N'''-triacetylfusarinine C anabolism|negative regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|negative regulation of N',N'',N'''-triacetylfusarinine C formation|negative regulation of N',N'',N'''-triacetylfusarinine C synthesis http://purl.obolibrary.org/obo/GO_1900696 GO:1900699 biolink:BiologicalProcess negative regulation of o-orsellinic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process. go.json down regulation of o-orsellinic acid anabolism|down regulation of o-orsellinic acid biosynthesis|down regulation of o-orsellinic acid biosynthetic process|down regulation of o-orsellinic acid formation|down regulation of o-orsellinic acid synthesis|down-regulation of o-orsellinic acid anabolism|down-regulation of o-orsellinic acid biosynthesis|down-regulation of o-orsellinic acid biosynthetic process|down-regulation of o-orsellinic acid formation|down-regulation of o-orsellinic acid synthesis|downregulation of o-orsellinic acid anabolism|downregulation of o-orsellinic acid biosynthesis|downregulation of o-orsellinic acid biosynthetic process|downregulation of o-orsellinic acid formation|downregulation of o-orsellinic acid synthesis|inhibition of o-orsellinic acid anabolism|inhibition of o-orsellinic acid biosynthesis|inhibition of o-orsellinic acid biosynthetic process|inhibition of o-orsellinic acid formation|inhibition of o-orsellinic acid synthesis|negative regulation of o-orsellinic acid anabolism|negative regulation of o-orsellinic acid biosynthesis|negative regulation of o-orsellinic acid formation|negative regulation of o-orsellinic acid synthesis http://purl.obolibrary.org/obo/GO_1900699 GO:1900698 biolink:BiologicalProcess regulation of o-orsellinic acid biosynthetic process Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process. go.json regulation of o-orsellinic acid anabolism|regulation of o-orsellinic acid biosynthesis|regulation of o-orsellinic acid formation|regulation of o-orsellinic acid synthesis http://purl.obolibrary.org/obo/GO_1900698 GO:1900693 biolink:BiologicalProcess negative regulation of (+)-kotanin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process. go.json down regulation of (+)-kotanin anabolism|down regulation of (+)-kotanin biosynthesis|down regulation of (+)-kotanin biosynthetic process|down regulation of (+)-kotanin formation|down regulation of (+)-kotanin synthesis|down-regulation of (+)-kotanin anabolism|down-regulation of (+)-kotanin biosynthesis|down-regulation of (+)-kotanin biosynthetic process|down-regulation of (+)-kotanin formation|down-regulation of (+)-kotanin synthesis|downregulation of (+)-kotanin anabolism|downregulation of (+)-kotanin biosynthesis|downregulation of (+)-kotanin biosynthetic process|downregulation of (+)-kotanin formation|downregulation of (+)-kotanin synthesis|inhibition of (+)-kotanin anabolism|inhibition of (+)-kotanin biosynthesis|inhibition of (+)-kotanin biosynthetic process|inhibition of (+)-kotanin formation|inhibition of (+)-kotanin synthesis|negative regulation of (+)-kotanin anabolism|negative regulation of (+)-kotanin biosynthesis|negative regulation of (+)-kotanin formation|negative regulation of (+)-kotanin synthesis http://purl.obolibrary.org/obo/GO_1900693 GO:1900692 biolink:BiologicalProcess regulation of (+)-kotanin biosynthetic process Any process that modulates the frequency, rate or extent of (+)-kotanin biosynthetic process. go.json regulation of (+)-kotanin anabolism|regulation of (+)-kotanin biosynthesis|regulation of (+)-kotanin formation|regulation of (+)-kotanin synthesis http://purl.obolibrary.org/obo/GO_1900692 GO:1900695 biolink:BiologicalProcess regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process Any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process. go.json regulation of N',N'',N'''-triacetylfusarinine C anabolism|regulation of N',N'',N'''-triacetylfusarinine C biosynthesis|regulation of N',N'',N'''-triacetylfusarinine C formation|regulation of N',N'',N'''-triacetylfusarinine C synthesis http://purl.obolibrary.org/obo/GO_1900695 GO:1900694 biolink:BiologicalProcess positive regulation of (+)-kotanin biosynthetic process Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process. go.json activation of (+)-kotanin anabolism|activation of (+)-kotanin biosynthesis|activation of (+)-kotanin biosynthetic process|activation of (+)-kotanin formation|activation of (+)-kotanin synthesis|positive regulation of (+)-kotanin anabolism|positive regulation of (+)-kotanin biosynthesis|positive regulation of (+)-kotanin formation|positive regulation of (+)-kotanin synthesis|up regulation of (+)-kotanin anabolism|up regulation of (+)-kotanin biosynthesis|up regulation of (+)-kotanin biosynthetic process|up regulation of (+)-kotanin formation|up regulation of (+)-kotanin synthesis|up-regulation of (+)-kotanin anabolism|up-regulation of (+)-kotanin biosynthesis|up-regulation of (+)-kotanin biosynthetic process|up-regulation of (+)-kotanin formation|up-regulation of (+)-kotanin synthesis|upregulation of (+)-kotanin anabolism|upregulation of (+)-kotanin biosynthesis|upregulation of (+)-kotanin biosynthetic process|upregulation of (+)-kotanin formation|upregulation of (+)-kotanin synthesis http://purl.obolibrary.org/obo/GO_1900694 RO:0004007 biolink:OntologyClass has primary input or output RO:0004007 go.json http://purl.obolibrary.org/obo/RO_0004007 RO:0004009 biolink:OntologyClass has primary input RO:0004009 go.json http://purl.obolibrary.org/obo/RO_0004009 RO:0004008 biolink:OntologyClass has primary output RO:0004008 go.json http://purl.obolibrary.org/obo/RO_0004008 GO:0071589 biolink:BiologicalProcess pyridine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose. go.json pyridine nucleoside anabolism|pyridine nucleoside biosynthesis|pyridine nucleoside formation|pyridine nucleoside synthesis http://purl.obolibrary.org/obo/GO_0071589 GO:0071588 biolink:BiologicalProcess hydrogen peroxide mediated signaling pathway The series of molecular signals mediated by the detection of hydrogen peroxide (H2O2). go.json H2O2 mediated signaling pathway|hydrogen peroxide mediated signalling pathway http://purl.obolibrary.org/obo/GO_0071588 GO:0071587 biolink:BiologicalProcess CAAX-box protein modification The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins. go.json http://purl.obolibrary.org/obo/GO_0071587 gocheck_do_not_annotate GO:0071586 biolink:BiologicalProcess CAAX-box protein processing The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. go.json http://purl.obolibrary.org/obo/GO_0071586 GO:0071585 biolink:BiologicalProcess detoxification of cadmium ion Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion. go.json http://purl.obolibrary.org/obo/GO_0071585 GO:0071584 biolink:BiologicalProcess negative regulation of zinc ion transmembrane import Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import. go.json http://purl.obolibrary.org/obo/GO_0071584 GO:0071572 biolink:BiologicalProcess histone H3-K56 deacetylation The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone. go.json http://purl.obolibrary.org/obo/GO_0071572 gocheck_do_not_annotate GO:0071571 biolink:BiologicalProcess obsolete LRR domain-mediated complex assembly OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction. go.json leucine-rich repeat domain-mediated complex assembly True http://purl.obolibrary.org/obo/GO_0071571 GO:0071570 biolink:BiologicalProcess cement gland development The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed. go.json http://purl.obolibrary.org/obo/GO_0071570 GO:0071579 biolink:BiologicalProcess regulation of zinc ion transport Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0071579 GO:0071578 biolink:BiologicalProcess zinc ion import across plasma membrane The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol. go.json high-affinity zinc II ion transmembrane import|high-affinity zinc II ion transport|low-affinity zinc II ion transport|zinc II ion plasma membrane import|zinc II ion transmembrane import|zinc import|zinc ion import into cell|zinc ion transmembrane import|zinc uptake http://purl.obolibrary.org/obo/GO_0071578 GO:0071577 biolink:BiologicalProcess zinc ion transmembrane transport A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json zinc II ion transmembrane transport|zinc ion membrane transport|zinc transmembrane transport http://purl.obolibrary.org/obo/GO_0071577 GO:0071576 biolink:MolecularActivity tetrahydrodictyopterin binding Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one. go.json D-threo-tetrahydrobiopterin|DH4 binding http://purl.obolibrary.org/obo/GO_0071576 GO:0071575 biolink:CellularComponent obsolete integral component of external side of plasma membrane OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane. go.json integral to external leaflet of plasma membrane|integral to external side of plasma membrane True http://purl.obolibrary.org/obo/GO_0071575 GO:0071574 biolink:BiologicalProcess protein localization to medial cortex A process in which a protein is transported to, or maintained in, the medial cortex. go.json protein localisation to medial cortex http://purl.obolibrary.org/obo/GO_0071574 GO:0071573 biolink:BiologicalProcess shelterin complex assembly The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. go.json Pot1 complex assembly|Pot1-Tpz1 complex assembly|shelterin complex formation|telosome assembly http://purl.obolibrary.org/obo/GO_0071573 GO:0007119 biolink:BiologicalProcess budding cell isotropic bud growth Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding. go.json isotropic bud growth http://purl.obolibrary.org/obo/GO_0007119 GO:0007118 biolink:BiologicalProcess budding cell apical bud growth Growth at the tip of a bud, in a cell that reproduces by budding. go.json apical bud growth http://purl.obolibrary.org/obo/GO_0007118 GO:0007117 biolink:BiologicalProcess budding cell bud growth The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. go.json bud growth http://purl.obolibrary.org/obo/GO_0007117 GO:0007116 biolink:BiologicalProcess regulation of cell budding Any process that modulates the frequency, rate or extent of the formation and growth of cell buds. go.json regulation of budding http://purl.obolibrary.org/obo/GO_0007116 GO:0046723 biolink:BiologicalProcess malic acid secretion The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue. go.json hydroxysuccinic acid secretion|malate secretion http://purl.obolibrary.org/obo/GO_0046723 GO:0007115 biolink:BiologicalProcess obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) OBSOLETE. (Was not defined before being made obsolete). go.json bud site selection/establishment of cell polarity (sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007115 GO:0007114 biolink:BiologicalProcess cell budding A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell. go.json budding http://purl.obolibrary.org/obo/GO_0007114 goslim_candida|goslim_yeast GO:0046722 biolink:BiologicalProcess lactic acid secretion The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue. go.json lactate secretion http://purl.obolibrary.org/obo/GO_0046722 GO:0007113 biolink:BiologicalProcess endomitotic cell cycle A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. Wikipedia:Mitosis#Endomitosis go.json endomitosis http://purl.obolibrary.org/obo/GO_0007113 GO:0046721 biolink:BiologicalProcess formic acid secretion The controlled release of formic acid, HCOOH, by a cell or a tissue. go.json formate secretion http://purl.obolibrary.org/obo/GO_0046721 GO:0007112 biolink:BiologicalProcess male meiosis cytokinesis A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells. go.json cytokinesis after male meiosis|cytokinesis involved in male meiotic cell cycle http://purl.obolibrary.org/obo/GO_0007112 GO:0046720 biolink:BiologicalProcess citric acid secretion The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue. go.json citrate secretion http://purl.obolibrary.org/obo/GO_0046720 GO:0007111 biolink:BiologicalProcess meiosis II cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells. go.json cytokinesis after meiosis II http://purl.obolibrary.org/obo/GO_0007111 GO:0007110 biolink:BiologicalProcess meiosis I cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells. go.json cytokinesis after meiosis I http://purl.obolibrary.org/obo/GO_0007110 GO:0046729 biolink:CellularComponent viral procapsid A stable empty viral capsid produced during the assembly of viruses. go.json http://purl.obolibrary.org/obo/GO_0046729 GO:0046728 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046728 GO:0046727 biolink:CellularComponent capsomere Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses. Wikipedia:Capsomere go.json capsomer http://purl.obolibrary.org/obo/GO_0046727 GO:0046726 biolink:BiologicalProcess positive regulation by virus of viral protein levels in host cell Any process where the infecting virus increases the levels of viral proteins in a cell. go.json activation of viral protein levels in host cell|positive regulation of viral protein levels|stimulation of viral protein levels in host cell|up regulation of viral protein levels in host cell|up-regulation of viral protein levels in host cell|upregulation of viral protein levels in host cell http://purl.obolibrary.org/obo/GO_0046726 GO:0046725 biolink:BiologicalProcess negative regulation by virus of viral protein levels in host cell Any process where the infecting virus reduces the levels of viral proteins in a cell. go.json down regulation of viral protein levels in host cell|down-regulation of viral protein levels in host cell|downregulation of viral protein levels in host cell|inhibition of viral protein levels in host cell|negative regulation of viral protein levels http://purl.obolibrary.org/obo/GO_0046725 GO:0046724 biolink:BiologicalProcess oxalic acid secretion The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue. go.json oxalate secretion http://purl.obolibrary.org/obo/GO_0046724 GO:0007129 biolink:BiologicalProcess homologous chromosome pairing at meiosis The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. Wikipedia:Synapsis go.json chromosomal pairing|chromosomal synapsis|synapsis http://purl.obolibrary.org/obo/GO_0007129 GO:0007128 biolink:BiologicalProcess meiotic prophase I The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. go.json http://purl.obolibrary.org/obo/GO_0007128 gocheck_do_not_annotate GO:0007127 biolink:BiologicalProcess meiosis I The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. Wikipedia:Meiosis#Meiosis_I go.json meiosis I nuclear division http://purl.obolibrary.org/obo/GO_0007127 GO:0007126 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007126 GO:0046734 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046734 GO:0007125 biolink:BiologicalProcess obsolete invasive growth OBSOLETE. (Was not defined before being made obsolete). go.json invasive growth True http://purl.obolibrary.org/obo/GO_0007125 GO:0046733 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046733 GO:0007124 biolink:BiologicalProcess pseudohyphal growth The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli. go.json http://purl.obolibrary.org/obo/GO_0007124 goslim_candida|goslim_yeast GO:0046732 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046732 GO:0007123 biolink:BiologicalProcess obsolete bud scar accumulation OBSOLETE. (Was not defined before being made obsolete). go.json bud scar accumulation True http://purl.obolibrary.org/obo/GO_0007123 GO:0046731 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046731 GO:0046730 biolink:BiologicalProcess obsolete induction by virus of host immune response OBSOLETE. The induction by a virus of an immune response in the host organism. go.json activation of host immune response by virus|active induction of host immune response by virus|active viral induction of host immune response|passive activation of host immune response by virus|passive induction of cell-mediated immune response in host by virus|passive induction of host cell-mediated immune response by virus|passive induction of host humoral immune response by virus|passive induction of host immune response by virus|passive induction of host innate immune response by virus|passive induction of humoral immune response in host by virus|passive induction of innate immune response in host by virus|passive viral activation of cell-mediated immune response in host|passive viral activation of humoral immune response in host|passive viral activation of innate immune response in host|passive viral induction of cell-mediated immune response in host|passive viral induction of host immune response|passive viral induction of humoral immune response in host|passive viral induction of innate immune response in host True http://purl.obolibrary.org/obo/GO_0046730 GO:0007122 biolink:BiologicalProcess obsolete loss of asymmetric budding OBSOLETE. (Was not defined before being made obsolete). go.json loss of asymmetric budding True http://purl.obolibrary.org/obo/GO_0007122 GO:0007121 biolink:BiologicalProcess bipolar cellular bud site selection The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell. go.json bipolar bud site selection|bipolar budding|polar budding http://purl.obolibrary.org/obo/GO_0007121 GO:0007120 biolink:BiologicalProcess axial cellular bud site selection The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell. go.json axial bud site selection|axial budding http://purl.obolibrary.org/obo/GO_0007120 GO:0046739 biolink:BiologicalProcess transport of virus in multicellular host The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs). go.json spread of virus in multicellular host|spread of virus within multicellular host|viral spread within multicellular host http://purl.obolibrary.org/obo/GO_0046739 GO:0046738 biolink:BiologicalProcess obsolete induction of innate immune response in host by virus OBSOLETE. The intentional, virally-encoded stimulation of an innate host defense response to viral infection. go.json active induction of innate immune response in host by virus|active viral induction of innate immune response in host True http://purl.obolibrary.org/obo/GO_0046738 GO:0046737 biolink:BiologicalProcess obsolete induction of cell-mediated immune response in host by virus OBSOLETE. The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection. go.json active induction of cell-mediated immune response in host by virus|active viral induction of cell-mediated immune response in host True http://purl.obolibrary.org/obo/GO_0046737 GO:0046736 biolink:BiologicalProcess obsolete induction of humoral immune response in host by virus OBSOLETE. The intentional, virally-encoded stimulation of a host humoral defense response to viral infection. go.json active induction of humoral immune response in host by virus|active viral induction of humoral immune response in host True http://purl.obolibrary.org/obo/GO_0046736 GO:0046735 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046735 GO:0046745 biolink:BiologicalProcess viral capsid secondary envelopment The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope. go.json ER membrane viral budding during viral capsid re-envelopment|Golgi membrane viral budding during viral capsid re-envelopment|endoplasmic reticulum membrane viral budding during viral capsid re-envelopment|inner nuclear membrane viral budding during viral capsid re-envelopment|nuclear membrane viral budding during viral capsid re-envelopment|outer nuclear membrane viral budding during viral capsid re-envelopment|plasma membrane viral budding during viral capsid re-envelopment|viral budding from ER membrane by viral capsid re-envelopment|viral budding from ER membrane during viral capsid re-envelopment|viral budding from Golgi membrane by viral capsid re-envelopment|viral budding from Golgi membrane during viral capsid re-envelopment|viral budding from inner nuclear membrane by viral capsid re-envelopment|viral budding from inner nuclear membrane during viral capsid re-envelopment|viral budding from nuclear membrane by viral capsid re-envelopment|viral budding from nuclear membrane during viral capsid re-envelopment|viral budding from outer nuclear membrane by viral capsid re-envelopment|viral budding from outer nuclear membrane during viral capsid re-envelopment|viral budding from plasma membrane by viral capsid re-envelopment|viral budding from plasma membrane during viral capsid re-envelopment|viral capsid re-envelopment|virus budding from ER membrane by viral capsid re-envelopment|virus budding from ER membrane during viral capsid re-envelopment|virus budding from Golgi membrane by viral capsid re-envelopment|virus budding from Golgi membrane during viral capsid re-envelopment|virus budding from inner nuclear membrane by viral capsid re-envelopment|virus budding from inner nuclear membrane during viral capsid re-envelopment|virus budding from nuclear membrane by viral capsid re-envelopment|virus budding from nuclear membrane during viral capsid re-envelopment|virus budding from outer nuclear membrane by viral capsid re-envelopment|virus budding from outer nuclear membrane during viral capsid re-envelopment|virus budding from plasma membrane during viral capsid re-envelopment http://purl.obolibrary.org/obo/GO_0046745 GO:0046744 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046744 GO:0046743 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046743 GO:0046742 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046742 GO:0046741 biolink:BiologicalProcess transport of virus in host, tissue to tissue The transport of a virus between tissues in a multicellular organism. go.json spread of virus in host, tissue to tissue|spread of virus within host, tissue to tissue|tissue to tissue spread of virus within host|viral spread within host, tissue to tissue http://purl.obolibrary.org/obo/GO_0046741 GO:0046740 biolink:BiologicalProcess transport of virus in host, cell to cell The transport of a virus between adjacent cells in a multicellular organism. VZ:1018 go.json cell to cell spread of virus within host|intercellular virus transport|spread of virus in host, cell to cell|spread of virus within host, cell to cell|viral spread within host, cell to cell http://purl.obolibrary.org/obo/GO_0046740 GO:0071709 biolink:BiologicalProcess membrane assembly The aggregation, arrangement and bonding together of a set of components to form a membrane. go.json http://purl.obolibrary.org/obo/GO_0071709 GO:0071708 biolink:BiologicalProcess immunoglobulin light chain V-J recombination The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). go.json immunoglobulin V(D)J joining|immunoglobulin V(D)J recombination|immunoglobulin V-J joining http://purl.obolibrary.org/obo/GO_0071708 GO:0071707 biolink:BiologicalProcess immunoglobulin heavy chain V-D-J recombination The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). go.json immunoglobulin V(D)J joining|immunoglobulin V(D)J recombination|immunoglobulin V-D-J joining http://purl.obolibrary.org/obo/GO_0071707 GO:0071706 biolink:BiologicalProcess tumor necrosis factor superfamily cytokine production The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json TNF superfamily production|TNFSF cytokine production http://purl.obolibrary.org/obo/GO_0071706 gocheck_do_not_annotate GO:0071705 biolink:BiologicalProcess nitrogen compound transport The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0071705 GO:0046749 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046749 GO:0071704 biolink:BiologicalProcess organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. go.json organic molecular entity metabolic process|organic molecular entity metabolism|organic substance metabolism http://purl.obolibrary.org/obo/GO_0071704 GO:0046748 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046748 GO:0071703 biolink:BiologicalProcess detection of organic substance The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal. go.json http://purl.obolibrary.org/obo/GO_0071703 GO:0046747 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046747 GO:0071702 biolink:BiologicalProcess organic substance transport The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. go.json http://purl.obolibrary.org/obo/GO_0071702 GO:0046746 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046746 GO:0071701 biolink:BiologicalProcess regulation of MAPK export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm. go.json regulation of MAPK export from cell nucleus|regulation of MAPK export out of nucleus|regulation of MAPK transport from nucleus to cytoplasm|regulation of MAPK-nucleus export|regulation of cytoplasmic translocation of MAP kinase|regulation of cytoplasmic translocation of mitogen-activated protein kinase http://purl.obolibrary.org/obo/GO_0071701 GO:0071700 biolink:BiologicalProcess olfactory placode maturation A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. go.json http://purl.obolibrary.org/obo/GO_0071700 GO:0007109 biolink:BiologicalProcess obsolete cytokinesis, completion of separation OBSOLETE. The process of finishing cell separation, which results in two physically separated cells. go.json completion of separation involved in cytokinesis|cytokinesis, completion of separation True http://purl.obolibrary.org/obo/GO_0007109 GO:0007108 biolink:BiologicalProcess obsolete cytokinesis, initiation of separation OBSOLETE. The process involved in starting cell separation. go.json cytokinesis, initiation of separation|initiation of separation involved in cytokinesis True http://purl.obolibrary.org/obo/GO_0007108 GO:0007107 biolink:BiologicalProcess membrane addition at site of cytokinesis Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. go.json cytokinesis, membrane recruitment/generation http://purl.obolibrary.org/obo/GO_0007107 GO:0007106 biolink:BiologicalProcess obsolete cytokinesis, protein recruitment OBSOLETE. (Was not defined before being made obsolete). go.json cytokinesis, protein recruitment True http://purl.obolibrary.org/obo/GO_0007106 GO:0007105 biolink:BiologicalProcess cytokinesis, division site positioning The process in which a contractile ring is positioned in a specific location. This process is critical for both for both symmetric and asymmetric cell divisions. go.json contractile ring localization|cytokinesis, site selection|division plane positioning|site selection involved in cell cycle cytokinesis|site selection involved in cytokinesis http://purl.obolibrary.org/obo/GO_0007105 GO:0007104 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007104 GO:0046756 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046756 GO:0046755 biolink:BiologicalProcess viral budding A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. VZ:1947 go.json viral capsid envelopment|virion budding|virus budding http://purl.obolibrary.org/obo/GO_0046755 GO:0007103 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007103 GO:0007102 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007102 GO:0046754 biolink:BiologicalProcess viral exocytosis The exit of a fully formed virion particles from the host cell by exocytosis via a host vesicle. go.json viral egress by exocytosis http://purl.obolibrary.org/obo/GO_0046754 GO:0007101 biolink:BiologicalProcess obsolete male meiosis centrosome cycle OBSOLETE. Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism. go.json centrosome cycle involved in male meiotic cell cycle True http://purl.obolibrary.org/obo/GO_0007101 GO:0046753 biolink:BiologicalProcess non-lytic viral release The exit of a viral particle from a host cell that does not involve cell lysis. go.json http://purl.obolibrary.org/obo/GO_0046753 GO:0046752 biolink:BiologicalProcess obsolete viral capsid precursor transport to host cell nucleus OBSOLETE. Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid. go.json establishment and maintenance of viral capsid precursor localization in nucleus|localization of viral capsid precursors in nucleus|nuclear localization of viral capsid precursors|viral capsid precursor localisation in host cell nucleus|viral capsid precursor localization in host cell nucleus|viral capsid precursor localization to host cell nucleus True http://purl.obolibrary.org/obo/GO_0046752 GO:0007100 biolink:BiologicalProcess mitotic centrosome separation Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. go.json http://purl.obolibrary.org/obo/GO_0007100 GO:0046751 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046751 GO:0046750 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046750 GO:0046759 biolink:BiologicalProcess obsolete lytic virus budding from plasma membrane OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis. go.json lytic plasma membrane viral budding|lytic viral budding from plasma membrane|lytic virus budding from plasma membrane True http://purl.obolibrary.org/obo/GO_0046759 GO:0046758 biolink:BiologicalProcess obsolete lytic virus budding from Golgi membrane OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis. go.json lytic Golgi membrane viral budding|lytic viral budding from Golgi membrane|lytic virus budding from Golgi membrane True http://purl.obolibrary.org/obo/GO_0046758 GO:0046757 biolink:BiologicalProcess obsolete lytic virus budding from ER membrane OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis. go.json lytic ER membrane viral budding|lytic endoplasmic reticulum membrane viral budding|lytic viral budding from ER membrane|lytic virus budding from ER membrane True http://purl.obolibrary.org/obo/GO_0046757 GO:0046767 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046767 GO:0046766 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046766 GO:0046765 biolink:BiologicalProcess viral budding from nuclear membrane A viral budding that starts with formation of a membrane curvature in the host nuclear membrane. go.json nuclear membrane viral budding|nuclear membrane viral budding during viral capsid envelopment|viral budding from nuclear membrane by viral capsid envelopment|viral budding from nuclear membrane during viral capsid envelopment|virus budding from nuclear membrane|virus budding from nuclear membrane by viral capsid envelopment|virus budding from nuclear membrane during viral capsid envelopment http://purl.obolibrary.org/obo/GO_0046765 GO:0046764 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046764 GO:0046763 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046763 GO:0046762 biolink:BiologicalProcess viral budding from endoplasmic reticulum membrane A viral budding that starts with formation of a membrane curvature in the host ER membrane. go.json ER membrane viral budding|ER membrane viral budding during viral capsid envelopment|endoplasmic reticulum membrane viral budding|endoplasmic reticulum membrane viral budding during viral capsid envelopment|viral budding from ER membrane|viral budding from ER membrane by viral capsid envelopment|viral budding from ER membrane during viral capsid envelopment|virus budding from ER membrane|virus budding from ER membrane by viral capsid envelopment|virus budding from ER membrane during viral capsid envelopment http://purl.obolibrary.org/obo/GO_0046762 GO:0046761 biolink:BiologicalProcess viral budding from plasma membrane A viral budding that starts with formation of a curvature in the host plasma membrane around which the virion particle assembles. go.json plasma membrane viral budding|plasma membrane viral budding during viral capsid envelopment|viral budding from plasma membrane by viral capsid envelopment|viral budding from plasma membrane during viral capsid envelopment|virus budding from plasma membrane|virus budding from plasma membrane by viral capsid envelopment|virus budding from plasma membrane during viral capsid envelopment http://purl.obolibrary.org/obo/GO_0046761 GO:0046760 biolink:BiologicalProcess viral budding from Golgi membrane A viral budding that starts with formation of a membrane curvature in the host Golgi membrane. go.json Golgi membrane viral budding|Golgi membrane viral budding during viral capsid envelopment|viral budding from Golgi membrane by viral capsid envelopment|viral budding from Golgi membrane during viral capsid envelopment|virus budding from Golgi membrane|virus budding from Golgi membrane by viral capsid envelopment|virus budding from Golgi membrane during viral capsid envelopment http://purl.obolibrary.org/obo/GO_0046760 GO:0071729 biolink:BiologicalProcess beak morphogenesis The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. go.json http://purl.obolibrary.org/obo/GO_0071729 GO:0071728 biolink:BiologicalProcess beak development The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. go.json http://purl.obolibrary.org/obo/GO_0071728 GO:0071727 biolink:BiologicalProcess cellular response to triacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus. go.json cellular response to triacylated bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0071727 GO:0071726 biolink:BiologicalProcess cellular response to diacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. go.json cellular response to diacylated bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0071726 GO:0071725 biolink:BiologicalProcess response to triacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus. go.json response to triacylated bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0071725 GO:0046769 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046769 GO:0071724 biolink:BiologicalProcess response to diacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. go.json response to diacylated bacterial lipoprotein http://purl.obolibrary.org/obo/GO_0071724 GO:0046768 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046768 GO:0071723 biolink:MolecularActivity lipopeptide binding Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids. go.json bacterial lipopeptide binding|bacterial lipoprotein binding http://purl.obolibrary.org/obo/GO_0071723 GO:0071722 biolink:BiologicalProcess detoxification of arsenic-containing substance Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds. go.json detoxification of arsenic http://purl.obolibrary.org/obo/GO_0071722 GO:0071721 biolink:BiologicalProcess sodium-independent thromboxane transport The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels. go.json http://purl.obolibrary.org/obo/GO_0071721 GO:0071720 biolink:BiologicalProcess sodium-independent prostaglandin transport The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0071720 GO:0046770 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046770 GO:1900606 biolink:BiologicalProcess tensidol B metabolic process The chemical reactions and pathways involving tensidol B. go.json tensidol B metabolism http://purl.obolibrary.org/obo/GO_1900606 GO:1900605 biolink:BiologicalProcess tensidol A biosynthetic process The chemical reactions and pathways resulting in the formation of tensidol A. go.json tensidol A anabolism|tensidol A biosynthesis|tensidol A formation|tensidol A synthesis http://purl.obolibrary.org/obo/GO_1900605 GO:1900608 biolink:BiologicalProcess tensidol B biosynthetic process The chemical reactions and pathways resulting in the formation of tensidol B. go.json tensidol B anabolism|tensidol B biosynthesis|tensidol B formation|tensidol B synthesis http://purl.obolibrary.org/obo/GO_1900608 GO:1900607 biolink:BiologicalProcess tensidol B catabolic process The chemical reactions and pathways resulting in the breakdown of tensidol B. go.json tensidol B breakdown|tensidol B catabolism|tensidol B degradation http://purl.obolibrary.org/obo/GO_1900607 GO:1900602 biolink:BiologicalProcess endocrocin biosynthetic process The chemical reactions and pathways resulting in the formation of endocrocin. go.json endocrocin anabolism|endocrocin biosynthesis|endocrocin formation|endocrocin synthesis http://purl.obolibrary.org/obo/GO_1900602 GO:1900601 biolink:BiologicalProcess endocrocin catabolic process The chemical reactions and pathways resulting in the breakdown of endocrocin. go.json endocrocin breakdown|endocrocin catabolism|endocrocin degradation http://purl.obolibrary.org/obo/GO_1900601 GO:1900604 biolink:BiologicalProcess tensidol A catabolic process The chemical reactions and pathways resulting in the breakdown of tensidol A. go.json tensidol A breakdown|tensidol A catabolism|tensidol A degradation http://purl.obolibrary.org/obo/GO_1900604 GO:1900603 biolink:BiologicalProcess tensidol A metabolic process The chemical reactions and pathways involving tensidol A. go.json tensidol A metabolism http://purl.obolibrary.org/obo/GO_1900603 GO:0046778 biolink:BiologicalProcess modification by virus of host mRNA processing Any viral process that interferes with the processing of mRNA in the host cell. go.json viral perturbation of host mRNA processing http://purl.obolibrary.org/obo/GO_0046778 GO:0046777 biolink:BiologicalProcess protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). Wikipedia:Autophosphorylation go.json protein amino acid autophosphorylation http://purl.obolibrary.org/obo/GO_0046777 gocheck_do_not_annotate GO:0046776 biolink:BiologicalProcess suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response. go.json inhibition of host MHC class I molecule presentation by virus|negative regulation by virus of MHC class I cell surface presentation|suppression by virus of MHC class I cell surface presentation in host|suppression by virus of host MHC class I cell surface presentation|suppression by virus of host tapasin activity http://purl.obolibrary.org/obo/GO_0046776 GO:1900600 biolink:BiologicalProcess endocrocin metabolic process The chemical reactions and pathways involving endocrocin. go.json endocrocin metabolism http://purl.obolibrary.org/obo/GO_1900600 GO:0046775 biolink:BiologicalProcess suppression by virus of host cytokine production Any viral process that results in the inhibition of host cell cytokine production. go.json negative regulation by virus of host cytokine production http://purl.obolibrary.org/obo/GO_0046775 GO:0046774 biolink:BiologicalProcess suppression by virus of host intracellular interferon activity Any viral process that results in the inhibition of interferon activity within the host cell. go.json negative regulation by virus of intracellular interferon activity|suppression by virus of intracellular interferon activity in host http://purl.obolibrary.org/obo/GO_0046774 GO:0046773 biolink:BiologicalProcess suppression by virus of host translation termination Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA. go.json negative regulation by virus of host cell protein biosynthesis shutoff|negative regulation by virus of host cell protein biosynthetic process shutoff|suppression by virus of host termination of protein biosynthetic process|viral inhibition of host cell protein biosynthesis shutoff|viral inhibition of host cell protein biosynthetic process shutoff|viral inhibition of termination of host cell protein biosynthesis|viral inhibition of termination of host cell protein biosynthetic process|viral suppression of termination by host of host cell protein biosynthesis|viral suppression of termination by host of host cell protein biosynthetic process http://purl.obolibrary.org/obo/GO_0046773 GO:0046772 biolink:BiologicalProcess viral budding from outer nuclear membrane The envelopment of a virus, in which the naked capsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope. go.json outer nuclear membrane viral budding during viral capsid envelopment|viral budding from outer nuclear membrane during viral capsid envelopment|virus budding from outer nuclear membrane by viral capsid envelopment|virus budding from outer nuclear membrane during viral capsid envelopment http://purl.obolibrary.org/obo/GO_0046772 GO:0046771 biolink:BiologicalProcess viral budding from inner nuclear membrane The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope. go.json inner nuclear membrane viral budding during viral capsid envelopment|viral budding from inner nuclear membrane by viral capsid envelopment|viral budding from inner nuclear membrane during viral capsid envelopment|virus budding from inner nuclear membrane by viral capsid envelopment|virus budding from inner nuclear membrane during viral capsid envelopment http://purl.obolibrary.org/obo/GO_0046771 GO:0071719 biolink:BiologicalProcess sodium-independent leukotriene transport The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. go.json http://purl.obolibrary.org/obo/GO_0071719 GO:0071718 biolink:BiologicalProcess sodium-independent icosanoid transport The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. go.json sodium-independent eicosanoid transport http://purl.obolibrary.org/obo/GO_0071718 GO:0071717 biolink:BiologicalProcess thromboxane transport The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels. go.json http://purl.obolibrary.org/obo/GO_0071717 GO:0071716 biolink:BiologicalProcess leukotriene transport The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. go.json http://purl.obolibrary.org/obo/GO_0071716 GO:0071715 biolink:BiologicalProcess icosanoid transport The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. go.json eicosanoid transport http://purl.obolibrary.org/obo/GO_0071715 GO:0071714 biolink:MolecularActivity icosanoid transmembrane transporter activity Enables the transfer of icosanoids from one side of a membrane to the other. go.json eicosanoid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0071714 GO:0071713 biolink:MolecularActivity para-aminobenzoyl-glutamate hydrolase activity Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate. go.json http://purl.obolibrary.org/obo/GO_0071713 GO:0046779 biolink:BiologicalProcess obsolete suppression by virus of expression of host genes with introns OBSOLETE. Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed. go.json negative regulation by virus of expression of host genes with introns|viral inhibition of expression of host genes with introns True http://purl.obolibrary.org/obo/GO_0046779 GO:0071712 biolink:BiologicalProcess ER-associated misfolded protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. go.json ER-associated misfolded protein breakdown|ER-associated misfolded protein catabolism|ER-associated misfolded protein degradation|endoplasmic reticulum-associated misfolded protein catabolic process|endoplasmic reticulum-associated misfolded protein catabolism|proteasomal protein catabolism of misfolded ER proteins http://purl.obolibrary.org/obo/GO_0071712 GO:0071711 biolink:BiologicalProcess basement membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. go.json basement membrane organisation http://purl.obolibrary.org/obo/GO_0071711 GO:0071710 biolink:BiologicalProcess membrane macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell. go.json membrane macromolecule anabolism|membrane macromolecule biosynthesis|membrane macromolecule formation|membrane macromolecule synthesis http://purl.obolibrary.org/obo/GO_0071710 GO:1900609 biolink:BiologicalProcess F-9775A metabolic process The chemical reactions and pathways involving F-9775A. go.json F-9775A metabolism http://purl.obolibrary.org/obo/GO_1900609 GO:0046781 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046781 GO:1900617 biolink:BiologicalProcess emericellamide A biosynthetic process The chemical reactions and pathways resulting in the formation of emericellamide A. go.json emericellamide A anabolism|emericellamide A biosynthesis|emericellamide A formation|emericellamide A synthesis http://purl.obolibrary.org/obo/GO_1900617 GO:0046780 biolink:BiologicalProcess suppression by virus of host mRNA splicing Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production. go.json negative regulation by virus of host mRNA splicing|suppression by virus of host splicing factor activity|viral dispersion of host splicing factors|viral inhibition of host mRNA splicing http://purl.obolibrary.org/obo/GO_0046780 GO:1900616 biolink:BiologicalProcess emericellamide A catabolic process The chemical reactions and pathways resulting in the breakdown of emericellamide A. go.json emericellamide A breakdown|emericellamide A catabolism|emericellamide A degradation http://purl.obolibrary.org/obo/GO_1900616 GO:1900619 biolink:BiologicalProcess acetate ester metabolic process The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. go.json acetate ester metabolism|acetyl ester metabolic process|acetyl ester metabolism http://purl.obolibrary.org/obo/GO_1900619 GO:1900618 biolink:BiologicalProcess regulation of shoot system morphogenesis Any process that modulates the frequency, rate or extent of shoot morphogenesis. go.json regulation of shoot morphogenesis http://purl.obolibrary.org/obo/GO_1900618 GO:1900613 biolink:BiologicalProcess F-9775B catabolic process The chemical reactions and pathways resulting in the breakdown of F-9775B. go.json F-9775B breakdown|F-9775B catabolism|F-9775B degradation http://purl.obolibrary.org/obo/GO_1900613 GO:1900612 biolink:BiologicalProcess F-9775B metabolic process The chemical reactions and pathways involving F-9775B. go.json F-9775B metabolism http://purl.obolibrary.org/obo/GO_1900612 GO:1900615 biolink:BiologicalProcess emericellamide A metabolic process The chemical reactions and pathways involving emericellamide A. go.json emericellamide A metabolism http://purl.obolibrary.org/obo/GO_1900615 GO:1900614 biolink:BiologicalProcess F-9775B biosynthetic process The chemical reactions and pathways resulting in the formation of F-9775B. go.json F-9775B anabolism|F-9775B biosynthesis|F-9775B formation|F-9775B synthesis http://purl.obolibrary.org/obo/GO_1900614 GO:0046789 biolink:MolecularActivity host cell surface receptor binding Binding to a receptor on the host cell surface. go.json cell surface antigen activity, host-interacting|cell surface receptor ligand http://purl.obolibrary.org/obo/GO_0046789 goslim_chembl GO:0046788 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046788 GO:1900611 biolink:BiologicalProcess F-9775A biosynthetic process The chemical reactions and pathways resulting in the formation of F-9775A. go.json F-9775A anabolism|F-9775A biosynthesis|F-9775A formation|F-9775A synthesis http://purl.obolibrary.org/obo/GO_1900611 GO:0046787 biolink:BiologicalProcess viral DNA repair The process of restoring viral DNA after damage or errors in replication. go.json http://purl.obolibrary.org/obo/GO_0046787 GO:1900610 biolink:BiologicalProcess F-9775A catabolic process The chemical reactions and pathways resulting in the breakdown of F-9775A. go.json F-9775A breakdown|F-9775A catabolism|F-9775A degradation http://purl.obolibrary.org/obo/GO_1900610 GO:0046786 biolink:BiologicalProcess viral replication complex formation and maintenance The process of organizing and assembling viral replication proteins in preparation for viral replication. go.json http://purl.obolibrary.org/obo/GO_0046786 GO:0046785 biolink:BiologicalProcess microtubule polymerization The addition of tubulin heterodimers to one or both ends of a microtubule. go.json microtubule assembly|microtubule formation http://purl.obolibrary.org/obo/GO_0046785 GO:0046784 biolink:BiologicalProcess viral mRNA export from host cell nucleus The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation. go.json intronless viral mRNA export from host cell nucleus|intronless viral mRNA export from host nucleus|intronless viral mRNA export out of nucleus|intronless viral mRNA transport from nucleus to cytoplasm|intronless viral mRNA-nucleus export http://purl.obolibrary.org/obo/GO_0046784 GO:0046783 biolink:BiologicalProcess modification by virus of host polysomes Any viral process that interferes with and inhibits the assembly and function of polysomes. go.json viral perturbation of polysomes http://purl.obolibrary.org/obo/GO_0046783 GO:0046782 biolink:BiologicalProcess regulation of viral transcription Any process that modulates the frequency, rate or extent of the transcription of the viral genome. go.json http://purl.obolibrary.org/obo/GO_0046782 GO:0071749 biolink:CellularComponent polymeric IgA immunoglobulin complex A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json pIgA antibody|pIgA1 antibody|polymeric IgA antibody|polymeric IgA1 antibody http://purl.obolibrary.org/obo/GO_0071749 GO:0071748 biolink:CellularComponent monomeric IgA immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json monomeric IgA antibody|monomeric IgA1 antibody|monomeric IgA2 antibody http://purl.obolibrary.org/obo/GO_0071748 GO:0071747 biolink:CellularComponent IgA B cell receptor complex An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json membrane-bound IgA|membrane-bound IgA1|membrane-bound IgA2|surface IgA|surface IgA1|surface IgA2 http://purl.obolibrary.org/obo/GO_0071747 GO:0071746 biolink:CellularComponent IgA immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json IgA antibody|IgA1 antibody|IgA2 antibody http://purl.obolibrary.org/obo/GO_0071746 GO:0071745 biolink:CellularComponent IgA immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json IgA1 antibody|IgA2 antibody http://purl.obolibrary.org/obo/GO_0071745 GO:0071744 biolink:CellularComponent IgE B cell receptor complex An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json membrane-bound IgE|surface IgE http://purl.obolibrary.org/obo/GO_0071744 GO:0071743 biolink:CellularComponent IgE immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json IgE antibody http://purl.obolibrary.org/obo/GO_0071743 GO:0071742 biolink:CellularComponent IgE immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0071742 GO:0071741 biolink:CellularComponent IgD immunoglobulin complex, GPI-anchored A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells. go.json GPI-anchored IgD http://purl.obolibrary.org/obo/GO_0071741 GO:0071740 biolink:CellularComponent IgD B cell receptor complex An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json membrane-bound IgD|surface IgD http://purl.obolibrary.org/obo/GO_0071740 GO:1900628 biolink:BiologicalProcess positive regulation of arugosin biosynthetic process Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process. go.json activation of arugosin anabolism|activation of arugosin biosynthesis|activation of arugosin biosynthetic process|activation of arugosin formation|activation of arugosin synthesis|positive regulation of arugosin anabolism|positive regulation of arugosin biosynthesis|positive regulation of arugosin formation|positive regulation of arugosin synthesis|up regulation of arugosin anabolism|up regulation of arugosin biosynthesis|up regulation of arugosin biosynthetic process|up regulation of arugosin formation|up regulation of arugosin synthesis|up-regulation of arugosin anabolism|up-regulation of arugosin biosynthesis|up-regulation of arugosin biosynthetic process|up-regulation of arugosin formation|up-regulation of arugosin synthesis|upregulation of arugosin anabolism|upregulation of arugosin biosynthesis|upregulation of arugosin biosynthetic process|upregulation of arugosin formation|upregulation of arugosin synthesis http://purl.obolibrary.org/obo/GO_1900628 GO:0046792 biolink:BiologicalProcess suppression by virus of host cell cycle arrest Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur. go.json negative regulation by virus of cell cycle arrest|viral inhibition of cell cycle arrest http://purl.obolibrary.org/obo/GO_0046792 GO:1900627 biolink:BiologicalProcess negative regulation of arugosin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of arugosin biosynthetic process. go.json down regulation of arugosin anabolism|down regulation of arugosin biosynthesis|down regulation of arugosin biosynthetic process|down regulation of arugosin formation|down regulation of arugosin synthesis|down-regulation of arugosin anabolism|down-regulation of arugosin biosynthesis|down-regulation of arugosin biosynthetic process|down-regulation of arugosin formation|down-regulation of arugosin synthesis|downregulation of arugosin anabolism|downregulation of arugosin biosynthesis|downregulation of arugosin biosynthetic process|downregulation of arugosin formation|downregulation of arugosin synthesis|inhibition of arugosin anabolism|inhibition of arugosin biosynthesis|inhibition of arugosin biosynthetic process|inhibition of arugosin formation|inhibition of arugosin synthesis|negative regulation of arugosin anabolism|negative regulation of arugosin biosynthesis|negative regulation of arugosin formation|negative regulation of arugosin synthesis http://purl.obolibrary.org/obo/GO_1900627 GO:0046791 biolink:BiologicalProcess obsolete suppression by virus of host complement neutralization OBSOLETE. Any viral process that results in the inhibition of complement neutralization of the host cell. go.json negative regulation by virus of host complement neutralization|suppression by virus of host complement neutralization True http://purl.obolibrary.org/obo/GO_0046791 GO:0046790 biolink:MolecularActivity virion binding Binding to a virion, either by binding to components of the capsid or the viral envelope. go.json http://purl.obolibrary.org/obo/GO_0046790 GO:1900629 biolink:BiologicalProcess methanophenazine metabolic process The chemical reactions and pathways involving methanophenazine. go.json methanophenazine metabolism http://purl.obolibrary.org/obo/GO_1900629 GO:1900624 biolink:BiologicalProcess negative regulation of monocyte aggregation Any process that stops, prevents or reduces the frequency, rate or extent of monocyte aggregation. go.json down regulation of monocyte aggregation|down regulation of mononuclear phagocyte aggregation|down-regulation of monocyte aggregation|down-regulation of mononuclear phagocyte aggregation|downregulation of monocyte aggregation|downregulation of mononuclear phagocyte aggregation|inhibition of monocyte aggregation|inhibition of mononuclear phagocyte aggregation|negative regulation of mononuclear phagocyte aggregation http://purl.obolibrary.org/obo/GO_1900624 GO:1900623 biolink:BiologicalProcess regulation of monocyte aggregation Any process that modulates the frequency, rate or extent of monocyte aggregation. go.json regulation of mononuclear phagocyte aggregation http://purl.obolibrary.org/obo/GO_1900623 GO:1900626 biolink:BiologicalProcess regulation of arugosin biosynthetic process Any process that modulates the frequency, rate or extent of arugosin biosynthetic process. go.json regulation of arugosin anabolism|regulation of arugosin biosynthesis|regulation of arugosin formation|regulation of arugosin synthesis http://purl.obolibrary.org/obo/GO_1900626 GO:1900625 biolink:BiologicalProcess positive regulation of monocyte aggregation Any process that activates or increases the frequency, rate or extent of monocyte aggregation. go.json activation of monocyte aggregation|activation of mononuclear phagocyte aggregation|positive regulation of mononuclear phagocyte aggregation|up regulation of monocyte aggregation|up regulation of mononuclear phagocyte aggregation|up-regulation of monocyte aggregation|up-regulation of mononuclear phagocyte aggregation|upregulation of monocyte aggregation|upregulation of mononuclear phagocyte aggregation http://purl.obolibrary.org/obo/GO_1900625 GO:1900620 biolink:BiologicalProcess acetate ester biosynthetic process The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. go.json acetate ester anabolism|acetate ester biosynthesis|acetate ester formation|acetate ester synthesis|acetyl ester biosynthesis|acetyl ester biosynthetic process http://purl.obolibrary.org/obo/GO_1900620 GO:0046799 biolink:BiologicalProcess recruitment of helicase-primase complex to DNA lesions The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair. go.json http://purl.obolibrary.org/obo/GO_0046799 GO:1900622 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling OBSOLETE. Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter. go.json activation of global transcription from RNA polymerase II promoter by calcium-mediated signaling|activation of transcription from RNA polymerase II promoter by calcium-mediated signaling|calcineurin-dependent transcription activation|calcineurin-dependent transcriptional induction|calcineurin-mediated activation of transcription|positive regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling|positive regulation of global transcription from Pol II promoter by calcium-mediated signaling|positive regulation of transcription from Pol II promoter by calcium-mediated signaling|positive regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling|stimulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling|stimulation of transcription from RNA polymerase II promoter by calcium-mediated signaling|up regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling|up regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling|up-regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling|up-regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling|upregulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling|upregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling True http://purl.obolibrary.org/obo/GO_1900622 GO:0046798 biolink:CellularComponent viral portal complex A multimeric ring of proteins through which the DNA enters and exits the viral capsid. go.json http://purl.obolibrary.org/obo/GO_0046798 GO:1900621 biolink:BiologicalProcess obsolete regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling OBSOLETE. Calcium-mediated signaling that results in regulation of transcription from an RNA polymerase II promoter. go.json regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling|regulation of global transcription from Pol II promoter by calcium-mediated signaling|regulation of transcription from Pol II promoter by calcium-mediated signaling|regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling True http://purl.obolibrary.org/obo/GO_1900621 GO:0046797 biolink:BiologicalProcess viral procapsid maturation The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure. UniProtKB-KW:KW-1273 go.json capsid maturation|viral capsid maturation|virion maturation http://purl.obolibrary.org/obo/GO_0046797 GO:0046796 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046796 GO:0046795 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046795 GO:0046794 biolink:BiologicalProcess transport of virus The directed movement of a virus, or part of a virus, into, out of, or within a host cell. go.json viral transport|virion transport http://purl.obolibrary.org/obo/GO_0046794 goslim_pir GO:0046793 biolink:BiologicalProcess obsolete induction by virus of phosphorylation of host RNA polymerase II OBSOLETE. Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II. go.json induction by virus of modification of host RNA polymerase II|virus-induced modification of host RNA polymerase II True http://purl.obolibrary.org/obo/GO_0046793 GO:0071739 biolink:CellularComponent IgD immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json IgD antibody http://purl.obolibrary.org/obo/GO_0071739 GO:0071738 biolink:CellularComponent IgD immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0071738 GO:0071737 biolink:CellularComponent IgG B cell receptor complex An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json membrane-bound IgG|membrane-bound IgG1|membrane-bound IgG2|membrane-bound IgG2a|membrane-bound IgG2b|membrane-bound IgG2c|membrane-bound IgG3|membrane-bound IgG4|surface IgG|surface IgG1|surface IgG2|surface IgG2a|surface IgG2b|surface IgG2c|surface IgG3|surface IgG4 http://purl.obolibrary.org/obo/GO_0071737 GO:0071736 biolink:CellularComponent IgG immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json IgG antibody|IgG1 antibody|IgG2 antibody|IgG2a antibody|IgG2b antibody|IgG2c antibody|IgG3 antibody|IgG4 antibody http://purl.obolibrary.org/obo/GO_0071736 GO:0071735 biolink:CellularComponent IgG immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json IgG1|IgG2|IgG2a|IgG2b|IgG2c|IgG3|IgG4 http://purl.obolibrary.org/obo/GO_0071735 GO:0071734 biolink:MolecularActivity biotin-[pyruvate-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase). EC:6.3.4.- go.json biotin-[pyruvate carboxylase] ligase activity|biotin-[pyruvate carboxylase] synthetase activity|biotin-pyruvate carboxylase synthetase activity|biotin-pyruvate-carboxylase ligase activity|biotin:apo-pyruvate-carboxylase ligase http://purl.obolibrary.org/obo/GO_0071734 GO:0071733 biolink:BiologicalProcess obsolete transcriptional activation by promoter-enhancer looping OBSOLETE. The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter. go.json long-range enhancer-promoter communication True http://purl.obolibrary.org/obo/GO_0071733 GO:0071732 biolink:BiologicalProcess cellular response to nitric oxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. go.json http://purl.obolibrary.org/obo/GO_0071732 GO:0071731 biolink:BiologicalProcess response to nitric oxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. go.json http://purl.obolibrary.org/obo/GO_0071731 GO:0071730 biolink:BiologicalProcess beak formation The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. go.json http://purl.obolibrary.org/obo/GO_0071730 GO:0007199 biolink:BiologicalProcess G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP). go.json G protein signaling, coupled to cGMP nucleotide second messenger|G protein signalling, coupled to cGMP nucleotide second messenger|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|G-protein signaling, coupled to cGMP nucleotide second messenger|G-protein signalling, coupled to cGMP nucleotide second messenger|GPCR signaling pathway via activation of guanylate cyclase activity|GPCR signaling pathway via cGMP second messenger|guanylate cyclase-activating G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007199 GO:0007198 biolink:BiologicalProcess adenylate cyclase-inhibiting serotonin receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. go.json inhibition of adenylate cyclase activity by serotonin receptor signaling pathway|inhibition of adenylate cyclase activity by serotonin receptor signalling pathway|serotonin receptor, adenylate cyclase inhibiting pathway|serotonin receptor, adenylyl cyclase inhibiting pathway http://purl.obolibrary.org/obo/GO_0007198 GO:0007197 biolink:BiologicalProcess adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process. go.json inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway|muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway|muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway http://purl.obolibrary.org/obo/GO_0007197 GO:0007196 biolink:BiologicalProcess adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process. go.json adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway|metabotropic glutamate receptor, adenylate cyclase inhibiting pathway|metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway http://purl.obolibrary.org/obo/GO_0007196 GO:0032151 biolink:CellularComponent mitotic septin complex A heterooligomeric septin complex that acts during mitotic cell division. go.json http://purl.obolibrary.org/obo/GO_0032151 GO:0032150 biolink:BiologicalProcess ubiquinone biosynthetic process from chorismate The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate. go.json http://purl.obolibrary.org/obo/GO_0032150 GO:0032159 biolink:CellularComponent septin cap A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. go.json http://purl.obolibrary.org/obo/GO_0032159 GO:0032158 biolink:CellularComponent septin band A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. go.json http://purl.obolibrary.org/obo/GO_0032158 GO:0032157 biolink:CellularComponent prospore contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis. go.json actomyosin ring|cytokinetic ring|meiotic contractile ring http://purl.obolibrary.org/obo/GO_0032157 GO:0032156 biolink:CellularComponent septin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. go.json http://purl.obolibrary.org/obo/GO_0032156 GO:0032155 biolink:CellularComponent obsolete cell division site part OBSOLETE. Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell. go.json cell division plane part True http://purl.obolibrary.org/obo/GO_0032155 GO:0032154 biolink:CellularComponent cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. Wikipedia:Cleavage_furrow go.json http://purl.obolibrary.org/obo/GO_0032154 GO:0032153 biolink:CellularComponent cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. go.json cell division plane http://purl.obolibrary.org/obo/GO_0032153 goslim_pir GO:0032152 biolink:CellularComponent meiotic septin complex A heterooligomeric septin complex that acts during meiotic cell division. go.json http://purl.obolibrary.org/obo/GO_0032152 GO:0032149 biolink:BiologicalProcess response to rhamnose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus. go.json response to L-rhamnose stimulus|response to rhamnose stimulus http://purl.obolibrary.org/obo/GO_0032149 GO:0032140 biolink:MolecularActivity single adenine insertion binding Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine. go.json http://purl.obolibrary.org/obo/GO_0032140 GO:0032148 biolink:BiologicalProcess activation of protein kinase B activity Any process that initiates the activity of the inactive enzyme protein kinase B. go.json protein kinase B activation http://purl.obolibrary.org/obo/GO_0032148 gocheck_do_not_annotate GO:0032147 biolink:BiologicalProcess activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase. go.json protein kinase activation http://purl.obolibrary.org/obo/GO_0032147 gocheck_do_not_annotate GO:0032146 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032146 GO:0032145 biolink:MolecularActivity succinate-semialdehyde dehydrogenase binding Binding to succinate-semialdehyde dehydrogenase. go.json succinic semialdehyde dehydrogenase binding http://purl.obolibrary.org/obo/GO_0032145 GO:0032144 biolink:CellularComponent 4-aminobutyrate transaminase complex A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity. go.json ABAT complex|GABA transaminase complex|GABA-T complex http://purl.obolibrary.org/obo/GO_0032144 GO:0032143 biolink:MolecularActivity single thymine insertion binding Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine. go.json http://purl.obolibrary.org/obo/GO_0032143 GO:0032142 biolink:MolecularActivity single guanine insertion binding Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine. go.json http://purl.obolibrary.org/obo/GO_0032142 GO:0032141 biolink:MolecularActivity single cytosine insertion binding Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine. go.json http://purl.obolibrary.org/obo/GO_0032141 GO:0032139 biolink:MolecularActivity dinucleotide insertion or deletion binding Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion. go.json dinucleotide insertion binding http://purl.obolibrary.org/obo/GO_0032139 GO:0032138 biolink:MolecularActivity single base insertion or deletion binding Binding to a double-stranded DNA region containing a single base insertion or deletion. go.json single base insertion binding http://purl.obolibrary.org/obo/GO_0032138 GO:0007179 biolink:BiologicalProcess transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json TGF-beta receptor signaling pathway|TGF-beta receptor signalling pathway|TGFbeta receptor signaling pathway|TGFbeta receptor signalling pathway|transforming growth factor beta receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007179 GO:0007178 biolink:BiologicalProcess transmembrane receptor protein serine/threonine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json transmembrane receptor protein serine/threonine kinase signalling pathway http://purl.obolibrary.org/obo/GO_0007178 GO:0007177 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007177 GO:0007176 biolink:BiologicalProcess regulation of epidermal growth factor-activated receptor activity Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. go.json regulation of EGF receptor activity|regulation of EGFR activity|regulation of epidermal growth factor receptor activity http://purl.obolibrary.org/obo/GO_0007176 gocheck_do_not_annotate GO:0007175 biolink:BiologicalProcess negative regulation of epidermal growth factor-activated receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity. go.json EGF receptor downregulation|down regulation of epidermal growth factor receptor activity|down-regulation of epidermal growth factor receptor activity|downregulation of epidermal growth factor receptor activity|inhibition of epidermal growth factor receptor activity|negative regulation of EGF receptor activity|negative regulation of EGFR activity|negative regulation of epidermal growth factor receptor activity http://purl.obolibrary.org/obo/GO_0007175 gocheck_do_not_annotate GO:0007174 biolink:BiologicalProcess epidermal growth factor catabolic process The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. go.json EGF breakdown|EGF catabolism|EGF receptor ligand processing|epidermal growth factor breakdown|epidermal growth factor catabolism|epidermal growth factor ligand processing|intracellular EGF processing|receptor-mediated EGF processing http://purl.obolibrary.org/obo/GO_0007174 GO:0007184 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007184 GO:0007183 biolink:BiologicalProcess obsolete SMAD protein complex assembly OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. go.json SMAD protein heteromerization True http://purl.obolibrary.org/obo/GO_0007183 GO:0007182 biolink:BiologicalProcess obsolete common-partner SMAD protein phosphorylation OBSOLETE. The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus. go.json co-SMAD protein phosphorylation|common mediator SMAD protein phosphorylation|common partner SMAD protein phosphorylation|common-mediator SMAD protein phosphorylation True http://purl.obolibrary.org/obo/GO_0007182 GO:0007181 biolink:BiologicalProcess transforming growth factor beta receptor complex assembly The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex. go.json TGF-beta receptor complex assembly|TGF-beta:type II receptor:type I receptor complex assembly|TGFbeta receptor complex assembly http://purl.obolibrary.org/obo/GO_0007181 GO:0007180 biolink:BiologicalProcess obsolete transforming growth factor beta ligand binding to type II receptor OBSOLETE. (Was not defined before being made obsolete). go.json TGF-beta ligand binding to type II receptor|TGFbeta ligand binding to type II receptor|transforming growth factor beta ligand binding to type II receptor True http://purl.obolibrary.org/obo/GO_0007180 GO:0032137 biolink:MolecularActivity guanine/thymine mispair binding Binding to a double-stranded DNA region containing a G/T mispair. go.json G/T mispair binding|T/G mispair binding|thymine/guanine mispair binding http://purl.obolibrary.org/obo/GO_0032137 GO:0032136 biolink:MolecularActivity adenine/cytosine mispair binding Binding to a double-stranded DNA region containing an A/C mispair. go.json A/C mispair binding|C/A mispair binding|cytosine/adenine mispair binding http://purl.obolibrary.org/obo/GO_0032136 GO:0032135 biolink:MolecularActivity DNA insertion or deletion binding Binding to a double-stranded DNA region containing an insertion or a deletion. go.json DNA insertion binding|insertion binding http://purl.obolibrary.org/obo/GO_0032135 GO:0032134 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032134 GO:0032133 biolink:CellularComponent chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. go.json CPC|CPC complex|chromosomal passenger complex http://purl.obolibrary.org/obo/GO_0032133 GO:0032132 biolink:MolecularActivity O6-alkylguanine-DNA binding Binding to an O6-alkylguanine adduct in DNA. go.json http://purl.obolibrary.org/obo/GO_0032132 GO:0032131 biolink:MolecularActivity alkylated DNA binding Binding to an alkylated residue in DNA. go.json http://purl.obolibrary.org/obo/GO_0032131 GO:0032130 biolink:BiologicalProcess medial membrane band assembly The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring. go.json medial membrane band formation http://purl.obolibrary.org/obo/GO_0032130 GO:0032129 biolink:MolecularActivity histone H3K9 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. go.json histone H3-K9 deacetylase activity|histone deacetylase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0032129 GO:0032128 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032128 GO:0032127 biolink:CellularComponent dense core granule membrane The lipid bilayer surrounding a dense core granule. go.json dense core vesicle membrane http://purl.obolibrary.org/obo/GO_0032127 GO:0007189 biolink:BiologicalProcess adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). go.json G protein signaling, adenylate cyclase activating pathway|G protein signaling, adenylyl cyclase activating pathway|G protein signalling, adenylate cyclase activating pathway|G protein signalling, adenylyl cyclase activating pathway|G-protein signaling, adenylate cyclase activating pathway|G-protein signaling, adenylyl cyclase activating pathway|G-protein signalling, adenylate cyclase activating pathway|G-protein signalling, adenylyl cyclase activating pathway|GPCR signaling pathway via activation of adenylate cyclase|GPCR signaling pathway via activation of adenylate cyclase activity|activation of adenylate cyclase activity by G-protein signaling pathway|activation of adenylate cyclase activity involved in G-protein signaling|adenylate cyclase-activating GPCR signaling pathway|positive regulation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of adenylate cyclase activity by G-protein signalling pathway|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007189 GO:0007188 biolink:BiologicalProcess adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). go.json G protein signaling, coupled to cAMP nucleotide second messenger|G protein signaling, coupled to cyclic AMP nucleotide second messenger|G protein signalling, coupled to cAMP nucleotide second messenger|G protein signalling, coupled to cyclic AMP nucleotide second messenger|G-protein signaling, coupled to cAMP nucleotide second messenger|G-protein signaling, coupled to cyclic AMP nucleotide second messenger|G-protein signalling, coupled to cAMP nucleotide second messenger|G-protein signalling, coupled to cyclic AMP nucleotide second messenger|GPCR signaling pathway via cAMP second messenger|GPCR signaling pathway via modulation of adenylate cyclase activity|adenylate cyclase-modulating GPCR signaling pathway http://purl.obolibrary.org/obo/GO_0007188 GO:0007187 biolink:BiologicalProcess G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. go.json G protein signaling, coupled to cyclic nucleotide second messenger|G protein signalling, coupled to cyclic nucleotide second messenger|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|G-protein signaling, coupled to cyclic nucleotide second messenger|G-protein signalling, coupled to cyclic nucleotide second messenger|GPCR signaling pathway via cyclic nucleotide second messenger http://purl.obolibrary.org/obo/GO_0007187 GO:0007186 biolink:BiologicalProcess G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. go.json G protein coupled receptor protein signaling pathway|G protein coupled receptor protein signalling pathway|G-protein coupled receptor protein signal transduction|G-protein coupled receptor protein signaling pathway|G-protein coupled receptor signaling pathway via GPCR dimer|G-protein coupled receptor signalling pathway|G-protein-coupled receptor protein signalling pathway|GPCR signaling pathway|GPCR signalling pathway|dimeric G-protein coupled receptor signaling pathway|dimeric G-protein coupled receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007186 goslim_drosophila GO:0007185 biolink:BiologicalProcess transmembrane receptor protein tyrosine phosphatase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json transmembrane receptor protein tyrosine phosphatase signalling pathway http://purl.obolibrary.org/obo/GO_0007185 GO:0007195 biolink:BiologicalProcess adenylate cyclase-inhibiting dopamine receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. go.json dopamine receptor, adenylate cyclase inhibiting pathway|dopamine receptor, adenylyl cyclase inhibiting pathway|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007195 GO:0007194 biolink:BiologicalProcess negative regulation of adenylate cyclase activity Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. go.json adenylate cyclase inhibitor|down regulation of adenylate cyclase activity|down-regulation of adenylate cyclase activity|downregulation of adenylate cyclase activity|inhibition of adenylate cyclase activity|negative regulation of adenylyl cyclase activity http://purl.obolibrary.org/obo/GO_0007194 gocheck_do_not_annotate GO:0007193 biolink:BiologicalProcess adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). go.json G protein signaling, adenylate cyclase inhibiting pathway|G protein signaling, adenylyl cyclase inhibiting pathway|G protein signalling, adenylate cyclase inhibiting pathway|G protein signalling, adenylyl cyclase inhibiting pathway|G-protein signaling, adenylate cyclase inhibiting pathway|G-protein signaling, adenylyl cyclase inhibiting pathway|G-protein signalling, adenylate cyclase inhibiting pathway|G-protein signalling, adenylyl cyclase inhibiting pathway|GPCR signaling pathway via inhibition of adenylate cyclase activity|adenylate cyclase-inhibiting GPCR signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway http://purl.obolibrary.org/obo/GO_0007193 GO:0007192 biolink:BiologicalProcess adenylate cyclase-activating serotonin receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. go.json activation of adenylate cyclase activity by serotonin receptor signalling pathway|serotonin receptor, adenylate cyclase activating pathway|serotonin receptor, adenylyl cyclase activating pathway http://purl.obolibrary.org/obo/GO_0007192 GO:0007191 biolink:BiologicalProcess adenylate cyclase-activating dopamine receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. go.json activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of adenylate cyclase activity by dopamine receptor signalling pathway|dopamine receptor, adenylate cyclase activating pathway|dopamine receptor, adenylyl cyclase activating pathway http://purl.obolibrary.org/obo/GO_0007191 GO:0007190 biolink:BiologicalProcess activation of adenylate cyclase activity Any process that initiates the activity of the inactive enzyme adenylate cyclase. go.json adenylate cyclase activation|adenylate cyclase activator|adenylyl cyclase activation http://purl.obolibrary.org/obo/GO_0007190 gocheck_do_not_annotate GO:0032126 biolink:CellularComponent eisosome A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization. Wikipedia:Eisosome go.json http://purl.obolibrary.org/obo/GO_0032126 GO:0032125 biolink:BiologicalProcess micronucleus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus. go.json micronuclear organization|micronuclear organization and biogenesis|micronucleus organisation http://purl.obolibrary.org/obo/GO_0032125 GO:0032124 biolink:BiologicalProcess macronucleus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus. go.json macronuclear organization|macronuclear organization and biogenesis|macronucleus organisation http://purl.obolibrary.org/obo/GO_0032124 GO:0032123 biolink:CellularComponent deep fiber Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm. go.json deep fibre http://purl.obolibrary.org/obo/GO_0032123 GO:0032122 biolink:BiologicalProcess oral apparatus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans. go.json oral apparatus morphogenesis|oral apparatus organisation|oral apparatus organization and biogenesis|stomatogenesis http://purl.obolibrary.org/obo/GO_0032122 GO:0032121 biolink:BiologicalProcess meiotic attachment of telomeric heterochromatin to spindle pole body The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation. go.json attachment of telomeres to spindle pole body|attachment of telomeric chromatin to spindle pole body http://purl.obolibrary.org/obo/GO_0032121 GO:0032120 biolink:BiologicalProcess ascospore-type prospore membrane formation The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed. go.json FSM assembly|FSM biosynthesis|FSM formation|ascospore-type prospore membrane assembly|forespore membrane biosynthesis|forespore membrane formation|prospore membrane biogenesis http://purl.obolibrary.org/obo/GO_0032120 GO:0032119 biolink:BiologicalProcess sequestering of zinc ion The process of binding or confining zinc ions such that they are separated from other components of a biological system. go.json http://purl.obolibrary.org/obo/GO_0032119 GO:0032118 biolink:BiologicalProcess horsetail-astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis. go.json horsetail-astral microtubule array organization|horsetail-astral microtubule organisation|horsetail-astral microtubule organization and biogenesis http://purl.obolibrary.org/obo/GO_0032118 GO:0032117 biolink:CellularComponent horsetail-astral microtubule array An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement. go.json HAA http://purl.obolibrary.org/obo/GO_0032117 GO:0032116 biolink:CellularComponent SMC loading complex A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved. go.json SCC2/SCC4 loading complex|chromatin loading complex|cohesin loading complex http://purl.obolibrary.org/obo/GO_0032116 GO:0007159 biolink:BiologicalProcess leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules. go.json leukocyte adhesion|leukocyte cell adhesion http://purl.obolibrary.org/obo/GO_0007159 GO:0007158 biolink:BiologicalProcess neuron cell-cell adhesion The attachment of a neuron to another cell via adhesion molecules. go.json neuron adhesion|neuronal cell adhesion http://purl.obolibrary.org/obo/GO_0007158 GO:0007157 biolink:BiologicalProcess heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. go.json agglutination http://purl.obolibrary.org/obo/GO_0007157 GO:0007156 biolink:BiologicalProcess homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. go.json http://purl.obolibrary.org/obo/GO_0007156 GO:0007155 biolink:BiologicalProcess cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. Wikipedia:Cell_adhesion go.json cell adhesion molecule activity|single organism cell adhesion http://purl.obolibrary.org/obo/GO_0007155 goslim_candida|goslim_chembl|goslim_drosophila|goslim_generic|goslim_metagenomics|goslim_pir|goslim_pombe|prokaryote_subset GO:0007154 biolink:BiologicalProcess cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Wikipedia:Cell_signaling go.json http://purl.obolibrary.org/obo/GO_0007154 goslim_pir|goslim_plant GO:0007153 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007153 GO:0007152 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007152 GO:0007162 biolink:BiologicalProcess negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. go.json cell adhesion receptor inhibitor activity|down regulation of cell adhesion|down-regulation of cell adhesion|downregulation of cell adhesion|inhibition of cell adhesion http://purl.obolibrary.org/obo/GO_0007162 GO:0007161 biolink:BiologicalProcess calcium-independent cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction. go.json calcium-independent cell adhesion molecule activity http://purl.obolibrary.org/obo/GO_0007161 GO:0007160 biolink:BiologicalProcess cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. go.json http://purl.obolibrary.org/obo/GO_0007160 GO:0032115 biolink:MolecularActivity sorbose reductase activity Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction. EC:1.1.1.289|KEGG_REACTION:R07346|MetaCyc:1.1.1.289-RXN|RHEA:14609 go.json D-glucitol:NADP+ oxidoreductase activity|Sou1p http://purl.obolibrary.org/obo/GO_0032115 GO:0032114 biolink:BiologicalProcess regulation of glucose-6-phosphatase activity Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate. go.json http://purl.obolibrary.org/obo/GO_0032114 gocheck_do_not_annotate GO:0032113 biolink:BiologicalProcess regulation of carbohydrate phosphatase activity Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate. go.json http://purl.obolibrary.org/obo/GO_0032113 gocheck_do_not_annotate GO:0032112 biolink:BiologicalProcess negative regulation of protein histidine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity. go.json down regulation of protein histidine kinase activity|down-regulation of protein histidine kinase activity|downregulation of protein histidine kinase activity|inhibition of protein histidine kinase activity|protein histidine kinase inhibitor http://purl.obolibrary.org/obo/GO_0032112 gocheck_do_not_annotate GO:0032111 biolink:BiologicalProcess obsolete activation of protein histidine kinase activity OBSOLETE. Any process that initiates the activity of an inactive protein histidine kinase. go.json protein histidine kinase activator True http://purl.obolibrary.org/obo/GO_0032111 GO:0032110 biolink:BiologicalProcess regulation of protein histidine kinase activity Any process that modulates the frequency, rate or extent of protein histidine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0032110 gocheck_do_not_annotate GO:0032109 biolink:BiologicalProcess positive regulation of response to nutrient levels Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. go.json activation of response to nutrient levels|stimulation of response to nutrient levels|up regulation of response to nutrient levels|up-regulation of response to nutrient levels|upregulation of response to nutrient levels http://purl.obolibrary.org/obo/GO_0032109 GO:0032108 biolink:BiologicalProcess negative regulation of response to nutrient levels Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. go.json down regulation of response to nutrient levels|down-regulation of response to nutrient levels|downregulation of response to nutrient levels|inhibition of response to nutrient levels http://purl.obolibrary.org/obo/GO_0032108 GO:0032107 biolink:BiologicalProcess regulation of response to nutrient levels Any process that modulates the frequency, rate or extent of a response to nutrient levels. go.json http://purl.obolibrary.org/obo/GO_0032107 GO:0032106 biolink:BiologicalProcess positive regulation of response to extracellular stimulus Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. go.json activation of response to extracellular stimulus|stimulation of response to extracellular stimulus|up regulation of response to extracellular stimulus|up-regulation of response to extracellular stimulus|upregulation of response to extracellular stimulus http://purl.obolibrary.org/obo/GO_0032106 GO:0032105 biolink:BiologicalProcess negative regulation of response to extracellular stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. go.json down regulation of response to extracellular stimulus|down-regulation of response to extracellular stimulus|downregulation of response to extracellular stimulus|inhibition of response to extracellular stimulus http://purl.obolibrary.org/obo/GO_0032105 GO:0007169 biolink:BiologicalProcess transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json transmembrane receptor protein tyrosine kinase signalling pathway http://purl.obolibrary.org/obo/GO_0007169 GO:0007168 biolink:BiologicalProcess receptor guanylyl cyclase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json receptor guanylyl cyclase signalling pathway http://purl.obolibrary.org/obo/GO_0007168 GO:0007167 biolink:BiologicalProcess enzyme-linked receptor protein signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json enzyme linked receptor protein signaling pathway|enzyme linked receptor protein signalling pathway http://purl.obolibrary.org/obo/GO_0007167 GO:0007166 biolink:BiologicalProcess cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. go.json cell surface receptor linked signal transduction|cell surface receptor linked signaling pathway|cell surface receptor linked signalling pathway http://purl.obolibrary.org/obo/GO_0007166 goslim_drosophila GO:0007165 biolink:BiologicalProcess signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Wikipedia:Signal_transduction go.json signal transduction by cis-phosphorylation|signal transduction by conformational transition|signal transduction by protein phosphorylation|signal transduction by trans-phosphorylation|signaling cascade|signaling pathway|signalling cascade|signalling pathway http://purl.obolibrary.org/obo/GO_0007165 goslim_candida|goslim_chembl|goslim_metagenomics|goslim_plant GO:0007164 biolink:BiologicalProcess establishment of tissue polarity Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. go.json http://purl.obolibrary.org/obo/GO_0007164 GO:0007163 biolink:BiologicalProcess establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. go.json cell polarity|establishment and/or maintenance of cell polarity|establishment and/or maintenance of cell polarization http://purl.obolibrary.org/obo/GO_0007163 goslim_drosophila|goslim_generic|goslim_pombe|prokaryote_subset GO:0007173 biolink:BiologicalProcess epidermal growth factor receptor signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. go.json EGF receptor signaling pathway|EGF receptor signalling pathway|EGFR signaling pathway|ERBB1 signaling pathway|epidermal growth factor receptor signalling pathway|receptor tyrosine-protein kinase erbB-1 signaling pathway http://purl.obolibrary.org/obo/GO_0007173 GO:0007172 biolink:BiologicalProcess signal complex assembly The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. go.json signal complex formation http://purl.obolibrary.org/obo/GO_0007172 GO:0007171 biolink:BiologicalProcess activation of transmembrane receptor protein tyrosine kinase activity Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. go.json transmembrane receptor protein tyrosine kinase activation|transmembrane receptor protein tyrosine kinase dimerization http://purl.obolibrary.org/obo/GO_0007171 gocheck_do_not_annotate GO:0007170 biolink:BiologicalProcess obsolete transmembrane receptor protein tyrosine kinase ligand binding OBSOLETE. (Was not defined before being made obsolete). go.json transmembrane receptor protein tyrosine kinase ligand binding True http://purl.obolibrary.org/obo/GO_0007170 GO:0032104 biolink:BiologicalProcess regulation of response to extracellular stimulus Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. go.json http://purl.obolibrary.org/obo/GO_0032104 GO:0032103 biolink:BiologicalProcess positive regulation of response to external stimulus Any process that activates, maintains or increases the rate of a response to an external stimulus. go.json activation of response to external stimulus|stimulation of response to external stimulus|up regulation of response to external stimulus|up-regulation of response to external stimulus|upregulation of response to external stimulus http://purl.obolibrary.org/obo/GO_0032103 gocheck_do_not_manually_annotate GO:0032102 biolink:BiologicalProcess negative regulation of response to external stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. go.json down regulation of response to external stimulus|down-regulation of response to external stimulus|downregulation of response to external stimulus|inhibition of response to external stimulus http://purl.obolibrary.org/obo/GO_0032102 gocheck_do_not_manually_annotate GO:0032101 biolink:BiologicalProcess regulation of response to external stimulus Any process that modulates the frequency, rate or extent of a response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0032101 gocheck_do_not_manually_annotate GO:0032100 biolink:BiologicalProcess positive regulation of appetite Any process that increases appetite. go.json activation of appetite|appetite stimulation|positive regulation of hunger|stimulation of appetite|up regulation of appetite|up-regulation of appetite|upregulation of appetite http://purl.obolibrary.org/obo/GO_0032100 GO:0007139 biolink:BiologicalProcess meiotic telophase II The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. go.json http://purl.obolibrary.org/obo/GO_0007139 gocheck_do_not_annotate GO:0007138 biolink:BiologicalProcess meiotic anaphase II The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II. go.json http://purl.obolibrary.org/obo/GO_0007138 gocheck_do_not_annotate GO:0046701 biolink:BiologicalProcess insecticide catabolic process The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects. go.json insecticide breakdown|insecticide catabolism|insecticide degradation http://purl.obolibrary.org/obo/GO_0046701 GO:0007137 biolink:BiologicalProcess meiotic metaphase II The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II. go.json http://purl.obolibrary.org/obo/GO_0007137 gocheck_do_not_annotate GO:0046700 biolink:BiologicalProcess heterocycle catabolic process The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). go.json heterocycle breakdown|heterocycle catabolism|heterocycle degradation http://purl.obolibrary.org/obo/GO_0046700 GO:0007136 biolink:BiologicalProcess meiotic prophase II The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. go.json http://purl.obolibrary.org/obo/GO_0007136 gocheck_do_not_annotate GO:0007135 biolink:BiologicalProcess meiosis II The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II. Wikipedia:Meiosis#Meiosis_II go.json meiosis II nuclear division http://purl.obolibrary.org/obo/GO_0007135 GO:0007134 biolink:BiologicalProcess meiotic telophase I The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. go.json http://purl.obolibrary.org/obo/GO_0007134 gocheck_do_not_annotate GO:0007133 biolink:BiologicalProcess meiotic anaphase I The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I. go.json http://purl.obolibrary.org/obo/GO_0007133 gocheck_do_not_annotate GO:0007132 biolink:BiologicalProcess meiotic metaphase I The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I. go.json http://purl.obolibrary.org/obo/GO_0007132 gocheck_do_not_annotate GO:0007131 biolink:BiologicalProcess reciprocal meiotic recombination The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. go.json female meiotic recombination|gene conversion with reciprocal crossover http://purl.obolibrary.org/obo/GO_0007131 GO:0007130 biolink:BiologicalProcess synaptonemal complex assembly The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination. go.json synaptonemal complex formation http://purl.obolibrary.org/obo/GO_0007130 GO:0046709 biolink:BiologicalProcess IDP catabolic process The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate. go.json IDP breakdown|IDP catabolism|IDP degradation http://purl.obolibrary.org/obo/GO_0046709 GO:0007140 biolink:BiologicalProcess male meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. go.json male meiosis|male nuclear division http://purl.obolibrary.org/obo/GO_0007140 GO:0046708 biolink:BiologicalProcess IDP biosynthetic process The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate. go.json IDP anabolism|IDP biosynthesis|IDP formation|IDP synthesis http://purl.obolibrary.org/obo/GO_0046708 GO:0046707 biolink:BiologicalProcess IDP metabolic process The chemical reactions and pathways involving IDP, inosine 5'-diphosphate. go.json IDP metabolism http://purl.obolibrary.org/obo/GO_0046707 GO:0046706 biolink:BiologicalProcess CDP catabolic process The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate. go.json CDP breakdown|CDP catabolism|CDP degradation http://purl.obolibrary.org/obo/GO_0046706 GO:0046705 biolink:BiologicalProcess CDP biosynthetic process The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate. go.json CDP anabolism|CDP biosynthesis|CDP formation|CDP synthesis http://purl.obolibrary.org/obo/GO_0046705 GO:0046704 biolink:BiologicalProcess CDP metabolic process The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate. go.json CDP metabolism http://purl.obolibrary.org/obo/GO_0046704 GO:0046703 biolink:MolecularActivity natural killer cell lectin-like receptor binding Binding to a lectin-like natural killer cell receptor. go.json KLRC4 receptor binding|NK cell lectin-like receptor binding|NKG2D receptor binding http://purl.obolibrary.org/obo/GO_0046703 GO:0046702 biolink:MolecularActivity galactoside 6-L-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside. go.json http://purl.obolibrary.org/obo/GO_0046702 GO:0007149 biolink:BiologicalProcess obsolete colony morphology OBSOLETE. (Was not defined before being made obsolete). go.json colony morphology True http://purl.obolibrary.org/obo/GO_0007149 GO:0046712 biolink:BiologicalProcess GDP catabolic process The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate. go.json GDP breakdown|GDP catabolism|GDP degradation http://purl.obolibrary.org/obo/GO_0046712 GO:0007148 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007148 GO:0007147 biolink:BiologicalProcess female meiosis II The cell cycle process in which the second meiotic division occurs in the female germline. go.json female meiosis II nuclear division http://purl.obolibrary.org/obo/GO_0007147 GO:0046711 biolink:BiologicalProcess GDP biosynthetic process The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate. go.json GDP anabolism|GDP biosynthesis|GDP formation|GDP synthesis http://purl.obolibrary.org/obo/GO_0046711 GO:0046710 biolink:BiologicalProcess GDP metabolic process The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. go.json GDP metabolism http://purl.obolibrary.org/obo/GO_0046710 GO:0007146 biolink:BiologicalProcess meiotic recombination nodule assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes. go.json http://purl.obolibrary.org/obo/GO_0007146 GO:0007145 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007145 GO:0007144 biolink:BiologicalProcess female meiosis I The cell cycle process in which the first meiotic division occurs in the female germline. go.json female meiosis I nuclear division http://purl.obolibrary.org/obo/GO_0007144 GO:0007143 biolink:BiologicalProcess female meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. go.json female meiosis|female meiotic division http://purl.obolibrary.org/obo/GO_0007143 GO:0007142 biolink:BiologicalProcess male meiosis II A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline. go.json male meiosis II nuclear division http://purl.obolibrary.org/obo/GO_0007142 GO:0007141 biolink:BiologicalProcess male meiosis I A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. go.json male meiosis I nuclear division http://purl.obolibrary.org/obo/GO_0007141 GO:0007151 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007151 GO:0007150 biolink:BiologicalProcess obsolete growth pattern OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances. go.json growth pattern True http://purl.obolibrary.org/obo/GO_0007150 GO:0046719 biolink:BiologicalProcess regulation by virus of viral protein levels in host cell Any virus-mediated process that modulates the levels of viral proteins in a cell. go.json regulation of viral protein levels http://purl.obolibrary.org/obo/GO_0046719 GO:0046718 biolink:BiologicalProcess viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. VZ:936 go.json entry of virus into host cell|phage translocation|viral penetration|virion penetration|virion penetration into host cell|virus entry into host cell http://purl.obolibrary.org/obo/GO_0046718 goslim_metagenomics GO:0046717 biolink:BiologicalProcess acid secretion The controlled release of acid by a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0046717 GO:0046716 biolink:BiologicalProcess muscle cell cellular homeostasis The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. go.json muscle fiber maintenance|muscle homeostasis http://purl.obolibrary.org/obo/GO_0046716 GO:0046715 biolink:MolecularActivity active borate transmembrane transporter activity Enables the transport of borate across a membrane against the concentration gradient. go.json borate transmembrane transporter activity|borate uptake transmembrane transporter activity|boron transmembrane transporter activity|boron uptake transmembrane transporter activity|efflux-type borate transporter|efflux-type boron transporter http://purl.obolibrary.org/obo/GO_0046715 GO:0046714 biolink:MolecularActivity borate binding Binding to borate, the anion (BO3)3-. go.json boron binding http://purl.obolibrary.org/obo/GO_0046714 GO:0046713 biolink:BiologicalProcess borate transport The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. go.json boron transport http://purl.obolibrary.org/obo/GO_0046713 GO:1900598 biolink:BiologicalProcess demethylkotanin catabolic process The chemical reactions and pathways resulting in the breakdown of demethylkotanin. go.json demethylkotanin breakdown|demethylkotanin catabolism|demethylkotanin degradation http://purl.obolibrary.org/obo/GO_1900598 GO:1900597 biolink:BiologicalProcess demethylkotanin metabolic process The chemical reactions and pathways involving demethylkotanin. go.json demethylkotanin metabolism http://purl.obolibrary.org/obo/GO_1900597 GO:1900599 biolink:BiologicalProcess demethylkotanin biosynthetic process The chemical reactions and pathways resulting in the formation of demethylkotanin. go.json demethylkotanin anabolism|demethylkotanin biosynthesis|demethylkotanin formation|demethylkotanin synthesis http://purl.obolibrary.org/obo/GO_1900599 GO:1900594 biolink:BiologicalProcess (+)-kotanin metabolic process The chemical reactions and pathways involving (+)-kotanin. go.json (+)-kotanin metabolism http://purl.obolibrary.org/obo/GO_1900594 GO:1900593 biolink:BiologicalProcess violaceol II biosynthetic process The chemical reactions and pathways resulting in the formation of violaceol II. go.json violaceol II anabolism|violaceol II biosynthesis|violaceol II formation|violaceol II synthesis http://purl.obolibrary.org/obo/GO_1900593 GO:1900596 biolink:BiologicalProcess (+)-kotanin biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-kotanin. go.json (+)-kotanin anabolism|(+)-kotanin biosynthesis|(+)-kotanin formation|(+)-kotanin synthesis http://purl.obolibrary.org/obo/GO_1900596 GO:1900595 biolink:BiologicalProcess (+)-kotanin catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-kotanin. go.json (+)-kotanin breakdown|(+)-kotanin catabolism|(+)-kotanin degradation http://purl.obolibrary.org/obo/GO_1900595 GO:0032096 biolink:BiologicalProcess negative regulation of response to food Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. go.json down regulation of response to food|down-regulation of response to food|downregulation of response to food|inhibition of response to food http://purl.obolibrary.org/obo/GO_0032096 GO:0032095 biolink:BiologicalProcess regulation of response to food Any process that modulates the frequency, rate or extent of a response to a food stimulus. go.json http://purl.obolibrary.org/obo/GO_0032095 GO:0032094 biolink:BiologicalProcess response to food Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. go.json http://purl.obolibrary.org/obo/GO_0032094 GO:0032093 biolink:MolecularActivity SAM domain binding Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. go.json Sterile Alpha Motif domain binding http://purl.obolibrary.org/obo/GO_0032093 GO:0032092 biolink:BiologicalProcess positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding. go.json activation of protein binding|stimulation of protein binding|up regulation of protein binding|up-regulation of protein binding|upregulation of protein binding http://purl.obolibrary.org/obo/GO_0032092 gocheck_do_not_annotate GO:0032091 biolink:BiologicalProcess negative regulation of protein binding Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. go.json down regulation of protein binding|down-regulation of protein binding|downregulation of protein binding|inhibition of protein binding http://purl.obolibrary.org/obo/GO_0032091 gocheck_do_not_annotate GO:0032090 biolink:MolecularActivity Pyrin domain binding Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain. go.json DAPIN domain binding|PAAD domain binding http://purl.obolibrary.org/obo/GO_0032090 GO:0032099 biolink:BiologicalProcess negative regulation of appetite Any process that reduces appetite. go.json appetite suppression|down regulation of appetite|down-regulation of appetite|downregulation of appetite|inhibition of appetite|negative regulation of hunger http://purl.obolibrary.org/obo/GO_0032099 GO:0032098 biolink:BiologicalProcess regulation of appetite Any process which modulates appetite, the desire or physical craving for food. go.json regulation of hunger http://purl.obolibrary.org/obo/GO_0032098 GO:0032097 biolink:BiologicalProcess positive regulation of response to food Any process that activates, maintains, or increases the rate of a response to a food stimulus. go.json activation of response to food|stimulation of response to food|up regulation of response to food|up-regulation of response to food|upregulation of response to food http://purl.obolibrary.org/obo/GO_0032097 GO:0032085 biolink:BiologicalProcess regulation of type II site-specific deoxyribonuclease activity Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity. go.json regulation of type II restriction endodeoxyribonuclease activity|type II restriction endodeoxyribonuclease regulator|type II restriction enzyme regulator http://purl.obolibrary.org/obo/GO_0032085 gocheck_do_not_annotate GO:0032084 biolink:BiologicalProcess regulation of type I site-specific deoxyribonuclease activity Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity. go.json regulation of type I restriction endodeoxyribonuclease activity|type I restriction endodeoxyribonuclease regulator|type I restriction enzyme regulator http://purl.obolibrary.org/obo/GO_0032084 gocheck_do_not_annotate GO:0032083 biolink:BiologicalProcess negative regulation of type IV site-specific deoxyribonuclease activity Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity. go.json down regulation of type IV restriction endodeoxyribonuclease activity|down-regulation of type IV restriction endodeoxyribonuclease activity|downregulation of type IV restriction endodeoxyribonuclease activity|inhibition of type IV restriction endodeoxyribonuclease activity|negative regulation of type IV restriction endodeoxyribonuclease activity|type IV restriction endodeoxyribonuclease inhibitor|type IV restriction enzyme inhibitor http://purl.obolibrary.org/obo/GO_0032083 gocheck_do_not_annotate GO:0032082 biolink:BiologicalProcess negative regulation of type III site-specific deoxyribonuclease activity Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity. go.json down regulation of type III restriction endodeoxyribonuclease activity|down-regulation of type III restriction endodeoxyribonuclease activity|downregulation of type III restriction endodeoxyribonuclease activity|inhibition of type III restriction endodeoxyribonuclease activity|negative regulation of type III restriction endodeoxyribonuclease activity|type III restriction endodeoxyribonuclease inhibitor|type III restriction enzyme inhibitor http://purl.obolibrary.org/obo/GO_0032082 gocheck_do_not_annotate GO:0032081 biolink:BiologicalProcess negative regulation of type II site-specific deoxyribonuclease activity Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity. go.json down regulation of type II restriction endodeoxyribonuclease activity|down-regulation of type II restriction endodeoxyribonuclease activity|downregulation of type II restriction endodeoxyribonuclease activity|inhibition of type II restriction endodeoxyribonuclease activity|negative regulation of type II restriction endodeoxyribonuclease activity|type II restriction endodeoxyribonuclease inhibitor|type II restriction enzyme inhibitor http://purl.obolibrary.org/obo/GO_0032081 gocheck_do_not_annotate GO:0032080 biolink:BiologicalProcess negative regulation of type I site-specific deoxyribonuclease activity Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity. go.json down regulation of type I restriction endodeoxyribonuclease activity|down-regulation of type I restriction endodeoxyribonuclease activity|downregulation of type I restriction endodeoxyribonuclease activity|inhibition of type I restriction endodeoxyribonuclease activity|negative regulation of type I restriction endodeoxyribonuclease activity|type I restriction endodeoxyribonuclease inhibitor|type I restriction enzyme inhibitor http://purl.obolibrary.org/obo/GO_0032080 gocheck_do_not_annotate GO:0032089 biolink:MolecularActivity NACHT domain binding Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs. go.json http://purl.obolibrary.org/obo/GO_0032089 GO:0032088 biolink:BiologicalProcess negative regulation of NF-kappaB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. go.json NF-kappaB inhibitor|inhibition of NF-kappaB transcription factor http://purl.obolibrary.org/obo/GO_0032088 gocheck_do_not_annotate GO:0032087 biolink:BiologicalProcess regulation of type IV site-specific deoxyribonuclease activity Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity. go.json regulation of type IV restriction endodeoxyribonuclease activity|type IV restriction endodeoxyribonuclease regulator|type IV restriction enzyme regulator http://purl.obolibrary.org/obo/GO_0032087 gocheck_do_not_annotate GO:0032086 biolink:BiologicalProcess regulation of type III site-specific deoxyribonuclease activity Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity. go.json regulation of type III restriction endoribonuclease activity|type III restriction endodeoxyribonuclease regulator|type III restriction enzyme regulator http://purl.obolibrary.org/obo/GO_0032086 gocheck_do_not_annotate GO:0032074 biolink:BiologicalProcess negative regulation of nuclease activity Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. go.json down regulation of nuclease activity|down-regulation of nuclease activity|downregulation of nuclease activity|inhibition of nuclease activity|nuclease inhibitor http://purl.obolibrary.org/obo/GO_0032074 gocheck_do_not_annotate GO:0032073 biolink:BiologicalProcess negative regulation of restriction endodeoxyribonuclease activity Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. go.json down regulation of restriction endodeoxyribonuclease activity|down-regulation of restriction endodeoxyribonuclease activity|downregulation of restriction endodeoxyribonuclease activity|inhibition of restriction endodeoxyribonuclease activity|restriction alleviation|restriction endodeoxyribonuclease inhibitor|restriction enzyme inhibitor http://purl.obolibrary.org/obo/GO_0032073 gocheck_do_not_annotate GO:0032072 biolink:BiologicalProcess regulation of restriction endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. go.json http://purl.obolibrary.org/obo/GO_0032072 gocheck_do_not_annotate GO:0032071 biolink:BiologicalProcess regulation of endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. go.json endodeoxyribonuclease regulator http://purl.obolibrary.org/obo/GO_0032071 gocheck_do_not_annotate GO:0032070 biolink:BiologicalProcess regulation of deoxyribonuclease activity Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. go.json DNase regulator|deoxyribonuclease regulator http://purl.obolibrary.org/obo/GO_0032070 gocheck_do_not_annotate GO:0032079 biolink:BiologicalProcess positive regulation of endodeoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. go.json activation of endodeoxyribonuclease activity|endodeoxyribonuclease activator|stimulation of endodeoxyribonuclease activity|up regulation of endodeoxyribonuclease activity|up-regulation of endodeoxyribonuclease activity|upregulation of endodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0032079 gocheck_do_not_annotate GO:0032078 biolink:BiologicalProcess negative regulation of endodeoxyribonuclease activity Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. go.json down regulation of endodeoxyribonuclease activity|down-regulation of endodeoxyribonuclease activity|downregulation of endodeoxyribonuclease activity|endodeoxyribonuclease inhibitor|inhibition of endodeoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0032078 gocheck_do_not_annotate GO:0032077 biolink:BiologicalProcess positive regulation of deoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. go.json DNase activator|activation of deoxyribonuclease activity|deoxyribonuclease activator|stimulation of deoxyribonuclease activity|up regulation of deoxyribonuclease activity|up-regulation of deoxyribonuclease activity|upregulation of deoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0032077 gocheck_do_not_annotate GO:0032076 biolink:BiologicalProcess negative regulation of deoxyribonuclease activity Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. go.json DNase inhibitor|deoxyribonuclease inhibitor|down regulation of deoxyribonuclease activity|down-regulation of deoxyribonuclease activity|downregulation of deoxyribonuclease activity|inhibition of deoxyribonuclease activity http://purl.obolibrary.org/obo/GO_0032076 gocheck_do_not_annotate GO:0032075 biolink:BiologicalProcess positive regulation of nuclease activity Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. go.json activation of nuclease activity|nuclease activator|stimulation of nuclease activity|up regulation of nuclease activity|up-regulation of nuclease activity|upregulation of nuclease activity http://purl.obolibrary.org/obo/GO_0032075 gocheck_do_not_annotate GO:0032063 biolink:BiologicalProcess negative regulation of translational initiation in response to osmotic stress Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json down regulation of translation initiation in response to osmotic stress|down-regulation of translation initiation in response to osmotic stress|downregulation of translation initiation in response to osmotic stress|inhibition of translation initiation in response to osmotic stress http://purl.obolibrary.org/obo/GO_0032063 GO:0032062 biolink:BiologicalProcess positive regulation of translation in response to osmotic stress Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json activation of translation in response to osmotic stress|stimulation of translation in response to osmotic stress|up regulation of translation in response to osmotic stress|up-regulation of translation in response to osmotic stress|upregulation of translation in response to osmotic stress http://purl.obolibrary.org/obo/GO_0032062 GO:0032061 biolink:BiologicalProcess negative regulation of translation in response to osmotic stress Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json down regulation of translation in response to osmotic stress|down-regulation of translation in response to osmotic stress|downregulation of translation in response to osmotic stress|inhibition of translation in response to osmotic stress http://purl.obolibrary.org/obo/GO_0032061 GO:0032060 biolink:BiologicalProcess bleb assembly The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. go.json blebbing|cell blebbing|membrane blebbing|plasma membrane bleb assembly|plasma membrane blebbing http://purl.obolibrary.org/obo/GO_0032060 GO:0032069 biolink:BiologicalProcess regulation of nuclease activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. go.json nuclease regulator activity http://purl.obolibrary.org/obo/GO_0032069 gocheck_do_not_annotate GO:0032068 biolink:CellularComponent type IV site-specific deoxyribonuclease complex A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation. go.json type IV restriction enzyme complex http://purl.obolibrary.org/obo/GO_0032068 GO:0032067 biolink:MolecularActivity type IV site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated). go.json type IV restriction enzyme activity http://purl.obolibrary.org/obo/GO_0032067 GO:0032066 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032066 GO:0032065 biolink:BiologicalProcess maintenance of protein location in cell cortex A process in which a protein or protein complex is maintained in a specific location in the cell cortex. go.json cortical protein anchoring http://purl.obolibrary.org/obo/GO_0032065 GO:0032064 biolink:BiologicalProcess positive regulation of translational initiation in response to osmotic stress Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. go.json activation of translation initiation in response to osmotic stress|stimulation of translation initiation in response to osmotic stress|up regulation of translation initiation in response to osmotic stress|up-regulation of translation initiation in response to osmotic stress|upregulation of translation initiation in response to osmotic stress http://purl.obolibrary.org/obo/GO_0032064 GO:0007099 biolink:BiologicalProcess centriole replication The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0. go.json centriole duplication|ciliary basal body duplication|microtubule basal body duplication http://purl.obolibrary.org/obo/GO_0007099 GO:0007098 biolink:BiologicalProcess centrosome cycle The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. go.json centrosome organisation|centrosome organization|centrosome organization and biogenesis http://purl.obolibrary.org/obo/GO_0007098 GO:0007097 biolink:BiologicalProcess nuclear migration The directed movement of the nucleus to a specific location within a cell. go.json establishment of cell nucleus localization|establishment of localization of nucleus|establishment of nucleus localisation|establishment of nucleus localization|establishment of position of nucleus|nuclear movement|nuclear positioning|nucleus migration|nucleus positioning|positioning of nucleus http://purl.obolibrary.org/obo/GO_0007097 GO:0032052 biolink:MolecularActivity bile acid binding Binding to a bile acid, a steroid carboxylic acids occurring in bile. go.json http://purl.obolibrary.org/obo/GO_0032052 GO:0032051 biolink:MolecularActivity clathrin light chain binding Binding to a clathrin light chain. go.json http://purl.obolibrary.org/obo/GO_0032051 GO:0032050 biolink:MolecularActivity clathrin heavy chain binding Binding to a clathrin heavy chain. go.json http://purl.obolibrary.org/obo/GO_0032050 GO:0032059 biolink:CellularComponent bleb A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. Wikipedia:Bleb_(cell_biology) go.json plasma membrane bleb http://purl.obolibrary.org/obo/GO_0032059 goslim_pir GO:0032058 biolink:BiologicalProcess positive regulation of translational initiation in response to stress Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. go.json activation of translation initiation in response to stress|stimulation of translation initiation in response to stress|up regulation of translation initiation in response to stress|up-regulation of translation initiation in response to stress|upregulation of translation initiation in response to stress http://purl.obolibrary.org/obo/GO_0032058 GO:0032057 biolink:BiologicalProcess negative regulation of translational initiation in response to stress Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. go.json down regulation of translation initiation in response to stress|down-regulation of translation initiation in response to stress|downregulation of translation initiation in response to stress|inhibition of translation initiation in response to stress http://purl.obolibrary.org/obo/GO_0032057 GO:0032056 biolink:BiologicalProcess positive regulation of translation in response to stress Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. go.json activation of translation in response to stress|stimulation of translation in response to stress|up regulation of translation in response to stress|up-regulation of translation in response to stress|upregulation of translation in response to stress http://purl.obolibrary.org/obo/GO_0032056 GO:0032055 biolink:BiologicalProcess negative regulation of translation in response to stress Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. go.json down regulation of translation in response to stress|down-regulation of translation in response to stress|downregulation of translation in response to stress|inhibition of translation in response to stress http://purl.obolibrary.org/obo/GO_0032055 GO:0032054 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032054 GO:0032053 biolink:BiologicalProcess ciliary basal body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum). go.json microtubule basal body organisation|microtubule basal body organization|microtubule basal body organization and biogenesis http://purl.obolibrary.org/obo/GO_0032053 GO:0032041 biolink:MolecularActivity NAD-dependent histone H3K14 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. go.json NAD-dependent histone H3-K14 deacetylase activity|NAD-dependent histone deacetylase activity (H3-K14 specific) http://purl.obolibrary.org/obo/GO_0032041 GO:0032040 biolink:CellularComponent small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. go.json SSU processome|small subunit processome http://purl.obolibrary.org/obo/GO_0032040 GO:0032049 biolink:BiologicalProcess cardiolipin biosynthetic process The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. MetaCyc:PWY-5269 go.json diphosphatidylglycerol biosynthesis|diphosphatidylglycerol biosynthetic process http://purl.obolibrary.org/obo/GO_0032049 GO:0032048 biolink:BiologicalProcess cardiolipin metabolic process The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. go.json cardiolipin metabolism|diphosphatidylglycerol metabolic process|diphosphatidylglycerol metabolism http://purl.obolibrary.org/obo/GO_0032048 GO:0032047 biolink:CellularComponent mitosome A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria. Wikipedia:Mitosome go.json crypton http://purl.obolibrary.org/obo/GO_0032047 GO:0032046 biolink:CellularComponent micropexophagy-specific membrane apparatus A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole. go.json MIPA|micropexophagic apparatus http://purl.obolibrary.org/obo/GO_0032046 GO:0032045 biolink:CellularComponent guanyl-nucleotide exchange factor complex A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. go.json http://purl.obolibrary.org/obo/GO_0032045 GO:0032044 biolink:CellularComponent DSIF complex A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. go.json 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex|DRB sensitivity inducing factor complex|Spt4-Spt5 complex|Spt5-Spt4 complex http://purl.obolibrary.org/obo/GO_0032044 GO:0032043 biolink:BiologicalProcess mitochondrial DNA catabolic process The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA. go.json mitochondrial DNA breakdown|mitochondrial DNA catabolism|mitochondrial DNA degradation|mtDNA breakdown|mtDNA catabolic process|mtDNA catabolism|mtDNA degradation http://purl.obolibrary.org/obo/GO_0032043 GO:0032042 biolink:BiologicalProcess mitochondrial DNA metabolic process The chemical reactions and pathways involving mitochondrial DNA. go.json mitochondrial DNA metabolism|mtDNA metabolic process|mtDNA metabolism http://purl.obolibrary.org/obo/GO_0032042 GO:1900518 biolink:BiologicalProcess regulation of response to pullulan Any process that modulates the frequency, rate or extent of response to pullulan. go.json http://purl.obolibrary.org/obo/GO_1900518 GO:0046682 biolink:BiologicalProcess response to cyclodiene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring. go.json cyclodiene resistance|cyclodiene susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046682 GO:1900517 biolink:BiologicalProcess positive regulation of xylose catabolic process to ethanol Any process that activates or increases the frequency, rate or extent of xylose catabolic process to ethanol. go.json activation of xylose catabolic process to ethanol|activation of xylose catabolism to ethanol|positive regulation of xylose catabolism to ethanol|up regulation of xylose catabolic process to ethanol|up regulation of xylose catabolism to ethanol|up-regulation of xylose catabolic process to ethanol|up-regulation of xylose catabolism to ethanol|upregulation of xylose catabolic process to ethanol|upregulation of xylose catabolism to ethanol http://purl.obolibrary.org/obo/GO_1900517 GO:0046681 biolink:BiologicalProcess response to carbamate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. go.json carbamate resistance|carbamate susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046681 GO:0046680 biolink:BiologicalProcess response to DDT Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals. go.json DDT resistance|DDT susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046680 GO:1900519 biolink:BiologicalProcess negative regulation of response to pullulan Any process that stops, prevents or reduces the frequency, rate or extent of response to pullulan. go.json down regulation of response to pullulan|down-regulation of response to pullulan|downregulation of response to pullulan|inhibition of response to pullulan http://purl.obolibrary.org/obo/GO_1900519 GO:1900514 biolink:BiologicalProcess positive regulation of starch utilization system complex assembly Any process that activates or increases the frequency, rate or extent of starch utilization system complex assembly. go.json activation of SUS complex assembly|activation of assembly of starch utilization system complex|activation of starch utilization system complex assembly|positive regulation of SUS complex assembly|positive regulation of assembly of starch utilization system complex|up regulation of SUS complex assembly|up regulation of assembly of starch utilization system complex|up regulation of starch utilization system complex assembly|up-regulation of SUS complex assembly|up-regulation of assembly of starch utilization system complex|up-regulation of starch utilization system complex assembly|upregulation of SUS complex assembly|upregulation of assembly of starch utilization system complex|upregulation of starch utilization system complex assembly http://purl.obolibrary.org/obo/GO_1900514 GO:1900513 biolink:BiologicalProcess negative regulation of starch utilization system complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of starch utilization system complex assembly. go.json down regulation of SUS complex assembly|down regulation of assembly of starch utilization system complex|down regulation of starch utilization system complex assembly|down-regulation of SUS complex assembly|down-regulation of assembly of starch utilization system complex|down-regulation of starch utilization system complex assembly|downregulation of SUS complex assembly|downregulation of assembly of starch utilization system complex|downregulation of starch utilization system complex assembly|inhibition of SUS complex assembly|inhibition of assembly of starch utilization system complex|inhibition of starch utilization system complex assembly|negative regulation of SUS complex assembly|negative regulation of assembly of starch utilization system complex http://purl.obolibrary.org/obo/GO_1900513 GO:1900516 biolink:BiologicalProcess negative regulation of xylose catabolic process to ethanol Any process that stops, prevents or reduces the frequency, rate or extent of xylose catabolic process to ethanol. go.json down regulation of xylose catabolic process to ethanol|down regulation of xylose catabolism to ethanol|down-regulation of xylose catabolic process to ethanol|down-regulation of xylose catabolism to ethanol|downregulation of xylose catabolic process to ethanol|downregulation of xylose catabolism to ethanol|inhibition of xylose catabolic process to ethanol|inhibition of xylose catabolism to ethanol|negative regulation of xylose catabolism to ethanol http://purl.obolibrary.org/obo/GO_1900516 GO:1900515 biolink:BiologicalProcess regulation of xylose catabolic process to ethanol Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol. go.json regulation of xylose catabolism to ethanol http://purl.obolibrary.org/obo/GO_1900515 GO:1900510 biolink:BiologicalProcess negative regulation of pentose catabolic process to ethanol Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol. go.json down regulation of pentose catabolic process to ethanol|down regulation of pentose catabolism to ethanol|down-regulation of pentose catabolic process to ethanol|down-regulation of pentose catabolism to ethanol|downregulation of pentose catabolic process to ethanol|downregulation of pentose catabolism to ethanol|inhibition of pentose catabolic process to ethanol|inhibition of pentose catabolism to ethanol|negative regulation of pentose catabolism to ethanol http://purl.obolibrary.org/obo/GO_1900510 GO:0046689 biolink:BiologicalProcess response to mercury ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. go.json mercuric sensitivity/resistance|response to mercuric ion|response to mercury http://purl.obolibrary.org/obo/GO_0046689 GO:1900512 biolink:BiologicalProcess regulation of starch utilization system complex assembly Any process that modulates the frequency, rate or extent of starch utilization system complex assembly. go.json regulation of SUS complex assembly|regulation of assembly of starch utilization system complex http://purl.obolibrary.org/obo/GO_1900512 GO:0046688 biolink:BiologicalProcess response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. go.json copper sensitivity/resistance|response to copper http://purl.obolibrary.org/obo/GO_0046688 GO:1900511 biolink:BiologicalProcess positive regulation of pentose catabolic process to ethanol Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol. go.json activation of pentose catabolic process to ethanol|activation of pentose catabolism to ethanol|positive regulation of pentose catabolism to ethanol|up regulation of pentose catabolic process to ethanol|up regulation of pentose catabolism to ethanol|up-regulation of pentose catabolic process to ethanol|up-regulation of pentose catabolism to ethanol|upregulation of pentose catabolic process to ethanol|upregulation of pentose catabolism to ethanol http://purl.obolibrary.org/obo/GO_1900511 GO:0046687 biolink:BiologicalProcess response to chromate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. go.json chromate sensitivity/resistance http://purl.obolibrary.org/obo/GO_0046687 GO:0046686 biolink:BiologicalProcess response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. go.json cadmium sensitivity/resistance|response to cadmium http://purl.obolibrary.org/obo/GO_0046686 GO:0046685 biolink:BiologicalProcess response to arsenic-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. go.json arsenate sensitivity/resistance|response to arsenic http://purl.obolibrary.org/obo/GO_0046685 GO:0046684 biolink:BiologicalProcess response to pyrethroid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage. go.json pyrethroid resistance|pyrethroid susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046684 GO:0046683 biolink:BiologicalProcess response to organophosphorus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. go.json organophosphorus resistance|organophosphorus susceptibility/resistance http://purl.obolibrary.org/obo/GO_0046683 GO:0071649 biolink:BiologicalProcess regulation of chemokine (C-C motif) ligand 5 production Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. go.json regulation of CCL5 production|regulation of RANTES production|regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production http://purl.obolibrary.org/obo/GO_0071649 GO:0071648 biolink:BiologicalProcess positive regulation of macrophage inflammatory protein-1 gamma production Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma. go.json positive regulation of CCL9 production|positive regulation of MIP-1g production|positive regulation of chemokine (C-C motif) ligand 9 production http://purl.obolibrary.org/obo/GO_0071648 GO:0071647 biolink:BiologicalProcess negative regulation of macrophage inflammatory protein-1 gamma production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma. go.json negative regulation of CCL9 production|negative regulation of MIP-1g production|negative regulation of chemokine (C-C motif) ligand 9 production http://purl.obolibrary.org/obo/GO_0071647 GO:0071646 biolink:BiologicalProcess regulation of macrophage inflammatory protein-1 gamma production Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma. go.json regulation of CCL9 production|regulation of MIP-1g production|regulation of chemokine (C-C motif) ligand 9 production http://purl.obolibrary.org/obo/GO_0071646 GO:0071645 biolink:BiologicalProcess positive regulation of chemokine (C-C motif) ligand 4 production Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. go.json positive regulation of CCL4 production|positive regulation of MIP-1b production|positive regulation of macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071645 GO:0071644 biolink:BiologicalProcess negative regulation of chemokine (C-C motif) ligand 4 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. go.json negative regulation of CCL4 production|negative regulation of MIP-1b production|negative regulation of macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071644 GO:0071643 biolink:BiologicalProcess regulation of chemokine (C-C motif) ligand 4 production Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. go.json regulation of CCL4 production|regulation of MIP-1b production|regulation of macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071643 GO:0071642 biolink:BiologicalProcess positive regulation of macrophage inflammatory protein 1 alpha production Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. go.json positive regulation of CCL3 production|positive regulation of MIP-1a production|positive regulation of chemokine (C-C motif) ligand 3 production|positive regulation of macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071642 GO:0071641 biolink:BiologicalProcess negative regulation of macrophage inflammatory protein 1 alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. go.json negative regulation of CCL3 production|negative regulation of MIP-1a production|negative regulation of chemokine (C-C motif) ligand 3 production|negative regulation of macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071641 GO:0071640 biolink:BiologicalProcess regulation of macrophage inflammatory protein 1 alpha production Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. go.json regulation of CCL3 production|regulation of MIP-1a production|regulation of chemokine (C-C motif) ligand 3 production|regulation of macrophage inflammatory protein production http://purl.obolibrary.org/obo/GO_0071640 GO:1900529 biolink:BiologicalProcess obsolete regulation of cell shape involved in cellular response to glucose starvation OBSOLETE. Any regulation of cell shape that is involved in cellular response to glucose starvation. go.json regulation of cell shape involved in cellular response to glucose starvation True http://purl.obolibrary.org/obo/GO_1900529 GO:0046693 biolink:BiologicalProcess sperm storage The retention of sperm by a female following mating. go.json retention of sperm|sequestering of sperm|sequestration of sperm|sperm retention|sperm sequestering|sperm sequestration|storage of sperm http://purl.obolibrary.org/obo/GO_0046693 GO:1900528 biolink:BiologicalProcess obsolete regulation of cell shape involved in G1 to G0 transition OBSOLETE. Any regulation of cell shape that is involved in G1 to G0 transition. go.json regulation of cell shape involved in G1 to G0 transition|regulation of cell shape involved in G1/G0 transition|regulation of cell shape involved in cell cycle quiescence|regulation of cell shape involved in establishment of cell quiescence|regulation of cell shape involved in stationary phase True http://purl.obolibrary.org/obo/GO_1900528 GO:0046692 biolink:BiologicalProcess sperm competition Any process that contributes to the success of sperm fertilization in multiply-mated females. Wikipedia:Sperm_competition go.json http://purl.obolibrary.org/obo/GO_0046692 GO:0046691 biolink:CellularComponent intracellular canaliculus An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates. go.json canalicular membrane http://purl.obolibrary.org/obo/GO_0046691 GO:0046690 biolink:BiologicalProcess response to tellurium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus. go.json response to tellurium|tellurium sensitivity/resistance http://purl.obolibrary.org/obo/GO_0046690 GO:1900525 biolink:BiologicalProcess obsolete positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json activation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter|activation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|activation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|activation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter|activation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter|up regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter|up regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter|up-regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|up-regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter|up-regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter|upregulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter|upregulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|upregulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter|upregulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900525 GO:1900524 biolink:BiologicalProcess obsolete positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json activation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter|up regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter|up-regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter|upregulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900524 GO:1900527 biolink:BiologicalProcess obsolete regulation of nucleus size involved in G1 to G0 transition OBSOLETE. Any regulation of nucleus size that is involved in G1 to G0 transition. go.json regulation of nuclear size involved in G1 to G0 transition|regulation of nuclear size involved in G1/G0 transition|regulation of nuclear size involved in cell cycle quiescence|regulation of nuclear size involved in establishment of cell quiescence|regulation of nuclear size involved in stationary phase|regulation of nuclear volume involved in G1 to G0 transition|regulation of nuclear volume involved in G1/G0 transition|regulation of nuclear volume involved in cell cycle quiescence|regulation of nuclear volume involved in establishment of cell quiescence|regulation of nuclear volume involved in stationary phase|regulation of nucleus size involved in G1 to G0 transition|regulation of nucleus size involved in G1/G0 transition|regulation of nucleus size involved in cell cycle quiescence|regulation of nucleus size involved in establishment of cell quiescence|regulation of nucleus size involved in stationary phase True http://purl.obolibrary.org/obo/GO_1900527 GO:1900526 biolink:BiologicalProcess obsolete negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. go.json negative regulation of phosphatidylserine anabolism by negative regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylserine biosynthesis by negative regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylserine formation by negative regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylserine synthesis by negative regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900526 GO:1900521 biolink:BiologicalProcess regulation of response to amylopectin Any process that modulates the frequency, rate or extent of response to amylopectin. go.json http://purl.obolibrary.org/obo/GO_1900521 GO:1900520 biolink:BiologicalProcess positive regulation of response to pullulan Any process that activates or increases the frequency, rate or extent of response to pullulan. go.json activation of response to pullulan|up regulation of response to pullulan|up-regulation of response to pullulan|upregulation of response to pullulan http://purl.obolibrary.org/obo/GO_1900520 GO:1900523 biolink:BiologicalProcess positive regulation of response to amylopectin Any process that activates or increases the frequency, rate or extent of response to amylopectin. go.json activation of response to amylopectin|up regulation of response to amylopectin|up-regulation of response to amylopectin|upregulation of response to amylopectin http://purl.obolibrary.org/obo/GO_1900523 GO:0046699 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046699 GO:1900522 biolink:BiologicalProcess negative regulation of response to amylopectin Any process that stops, prevents or reduces the frequency, rate or extent of response to amylopectin. go.json down regulation of response to amylopectin|down-regulation of response to amylopectin|downregulation of response to amylopectin|inhibition of response to amylopectin http://purl.obolibrary.org/obo/GO_1900522 GO:0046698 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046698 GO:0046697 biolink:BiologicalProcess decidualization The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. Wikipedia:Decidualization go.json decidual cell reaction http://purl.obolibrary.org/obo/GO_0046697 GO:0046696 biolink:CellularComponent lipopolysaccharide receptor complex A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens. go.json LPS receptor complex http://purl.obolibrary.org/obo/GO_0046696 GO:0046695 biolink:CellularComponent SLIK (SAGA-like) complex A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction. go.json SAGA (alt) complex|SALSA complex|SLIK/SALSA complex http://purl.obolibrary.org/obo/GO_0046695 GO:0046694 biolink:BiologicalProcess sperm incapacitation The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males. go.json http://purl.obolibrary.org/obo/GO_0046694 GO:0071639 biolink:BiologicalProcess positive regulation of monocyte chemotactic protein-1 production Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1. go.json positive regulation of CCL2 production|positive regulation of MCP-1 production http://purl.obolibrary.org/obo/GO_0071639 GO:0071638 biolink:BiologicalProcess negative regulation of monocyte chemotactic protein-1 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1. go.json negative regulation of CCL2 production|negative regulation of MCP-1 production http://purl.obolibrary.org/obo/GO_0071638 GO:0071637 biolink:BiologicalProcess regulation of monocyte chemotactic protein-1 production Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1. go.json regulation of CCL2 production|regulation of MCP-1 production http://purl.obolibrary.org/obo/GO_0071637 GO:0071636 biolink:BiologicalProcess positive regulation of transforming growth factor beta production Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. go.json positive regulation of TGF-B production|positive regulation of TGF-beta production|positive regulation of TGFB production|positive regulation of TGFbeta production|positive regulation of transforming growth factor-beta production|positive regulation of transforming growth factor-beta secretion http://purl.obolibrary.org/obo/GO_0071636 GO:0071635 biolink:BiologicalProcess negative regulation of transforming growth factor beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta. go.json negative regulation of TGF-B production|negative regulation of TGF-beta production|negative regulation of TGFB production|negative regulation of TGFbeta production|negative regulation of transforming growth factor-beta production|negative regulation of transforming growth factor-beta secretion http://purl.obolibrary.org/obo/GO_0071635 GO:0071634 biolink:BiologicalProcess regulation of transforming growth factor beta production Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. go.json regulation of TGF-B production|regulation of TGF-beta production|regulation of TGFB production|regulation of TGFbeta production|regulation of transforming growth factor-beta production|regulation of transforming growth factor-beta secretion http://purl.obolibrary.org/obo/GO_0071634 GO:0071633 biolink:MolecularActivity dihydroceramidase activity Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. go.json http://purl.obolibrary.org/obo/GO_0071633 GO:0071632 biolink:BiologicalProcess optomotor response Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish. Wikipedia:Optomotor_response go.json http://purl.obolibrary.org/obo/GO_0071632 GO:0071631 biolink:BiologicalProcess mating pheromone secretion involved in positive regulation of conjugation with cellular fusion The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that positively regulates a conjugation process that results in the union of cellular and genetic information from compatible mating types. go.json mating-type pheromone secretion involved in conjugation with cellular fusion|peptide pheromone export involved in positive regulation of conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0071631 GO:0071630 biolink:BiologicalProcess nuclear protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation. go.json nucleus-associated proteasomal ubiquitin-dependent protein breakdown|nucleus-associated proteasomal ubiquitin-dependent protein catabolism|nucleus-associated proteasomal ubiquitin-dependent protein degradation|ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome http://purl.obolibrary.org/obo/GO_0071630 GO:0071660 biolink:BiologicalProcess positive regulation of IP-10 production Any process that activates or increases the frequency, rate, or extent of production of IP-10. go.json positive regulation of CXCL10 production|positive regulation of chemokine (C-C motif) ligand 10 production http://purl.obolibrary.org/obo/GO_0071660 GO:1900539 biolink:BiologicalProcess fumonisin metabolic process The chemical reactions and pathways involving fumonisin. go.json fumonisin metabolism http://purl.obolibrary.org/obo/GO_1900539 GO:1900536 biolink:BiologicalProcess obsolete regulation of glucose homeostasis OBSOLETE. Any process that modulates the frequency, rate or extent of glucose homeostasis. go.json regulation of glucose homeostasis True http://purl.obolibrary.org/obo/GO_1900536 GO:1900535 biolink:BiologicalProcess palmitic acid biosynthetic process The chemical reactions and pathways resulting in the formation of palmitic acid. go.json http://purl.obolibrary.org/obo/GO_1900535 GO:1900538 biolink:BiologicalProcess obsolete positive regulation of glucose homeostasis OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose homeostasis. go.json activation of glucose homeostasis|positive regulation of glucose homeostasis|up regulation of glucose homeostasis|up-regulation of glucose homeostasis|upregulation of glucose homeostasis True http://purl.obolibrary.org/obo/GO_1900538 GO:1900537 biolink:BiologicalProcess obsolete negative regulation of glucose homeostasis OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose homeostasis. go.json down regulation of glucose homeostasis|down-regulation of glucose homeostasis|downregulation of glucose homeostasis|inhibition of glucose homeostasis|negative regulation of glucose homeostasis True http://purl.obolibrary.org/obo/GO_1900537 GO:1900532 biolink:BiologicalProcess obsolete negative regulation of cell proliferation involved in cellular hyperosmotic response OBSOLETE. Negative regulation of cell proliferation during cellular hyperosmotic response. go.json down regulation of cell proliferation of cellular HOG response|down regulation of cell proliferation of cellular hyperosmotic response|down regulation of cell proliferation of cellular hypertonic response|down regulation of cell proliferation of cellular response to hypertonicity|down-regulation of cell proliferation of cellular HOG response|down-regulation of cell proliferation of cellular hyperosmotic response|down-regulation of cell proliferation of cellular hypertonic response|down-regulation of cell proliferation of cellular response to hypertonicity|downregulation of cell proliferation of cellular HOG response|downregulation of cell proliferation of cellular hyperosmotic response|downregulation of cell proliferation of cellular hypertonic response|downregulation of cell proliferation of cellular response to hypertonicity|inhibition of cell proliferation of cellular HOG response|inhibition of cell proliferation of cellular hyperosmotic response|inhibition of cell proliferation of cellular hypertonic response|inhibition of cell proliferation of cellular response to hypertonicity|negative regulation of cell proliferation involved in cellular hyperosmotic response|negative regulation of cell proliferation of cellular HOG response|negative regulation of cell proliferation of cellular hyperosmotic response|negative regulation of cell proliferation of cellular hypertonic response|negative regulation of cell proliferation of cellular response to hypertonicity True http://purl.obolibrary.org/obo/GO_1900532 GO:1900531 biolink:BiologicalProcess obsolete regulation of cell shape involved in cellular response to heat OBSOLETE. Any regulation of cell shape that is involved in cellular response to heat. go.json regulation of cell shape involved in cellular response to heat|regulation of cell shape of cellular response to heat|regulation of cell shape of cellular response to heat stress True http://purl.obolibrary.org/obo/GO_1900531 GO:1900534 biolink:BiologicalProcess palmitic acid catabolic process The chemical reactions and pathways resulting in the breakdown of palmitic acid. go.json http://purl.obolibrary.org/obo/GO_1900534 GO:1900533 biolink:BiologicalProcess palmitic acid metabolic process The chemical reactions and pathways involving palmitic acid. go.json http://purl.obolibrary.org/obo/GO_1900533 GO:1900530 biolink:BiologicalProcess obsolete regulation of cell shape involved in cellular response to salt stress OBSOLETE. Any regulation of cell shape that is involved in cellular response to salt stress. go.json regulation of cell shape involved in cellular response to salt stress|regulation of cell shape of cellular response to ionic osmotic stress|regulation of cell shape of cellular response to salt stress|regulation of cell shape of cellular salinity response True http://purl.obolibrary.org/obo/GO_1900530 GO:0071669 biolink:BiologicalProcess plant-type cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall. go.json plant-type cell wall organisation or biogenesis|plant-type cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0071669 GO:0071668 biolink:BiologicalProcess plant-type cell wall assembly The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall. go.json plant cell wall assembly http://purl.obolibrary.org/obo/GO_0071668 GO:0071667 biolink:MolecularActivity DNA/RNA hybrid binding Binding to a RNA/DNA hybrid. go.json RNA/DNA hybrid binding http://purl.obolibrary.org/obo/GO_0071667 GO:0071666 biolink:CellularComponent Slit-Robo signaling complex A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate. go.json Slit-Robo signalling complex http://purl.obolibrary.org/obo/GO_0071666 GO:0071665 biolink:CellularComponent gamma-catenin-TCF7L2 complex A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. go.json gamma-catenin-TCF4 complex|plakoglobin-TCF4 complex http://purl.obolibrary.org/obo/GO_0071665 GO:0071664 biolink:CellularComponent catenin-TCF7L2 complex A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. go.json catenin-TCF4 complex http://purl.obolibrary.org/obo/GO_0071664 GO:0071663 biolink:BiologicalProcess positive regulation of granzyme B production Any process that activates or increases the frequency, rate, or extent of production of granzyme B. go.json http://purl.obolibrary.org/obo/GO_0071663 GO:0071662 biolink:BiologicalProcess negative regulation of granzyme B production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B. go.json http://purl.obolibrary.org/obo/GO_0071662 GO:0071661 biolink:BiologicalProcess regulation of granzyme B production Any process that modulates the frequency, rate, or extent of production of granzyme B. go.json http://purl.obolibrary.org/obo/GO_0071661 GO:1900547 biolink:BiologicalProcess obsolete negative regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of phenotypic switching. go.json negative regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900547 GO:1900546 biolink:BiologicalProcess obsolete positive regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of phenotypic switching. go.json activation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter|activation of phenotypic switching by regulation of transcription from RNA polymerase II promoter|positive regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter|up regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter|up regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter|up-regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter|up-regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter|upregulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter|upregulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900546 GO:1900549 biolink:BiologicalProcess N',N'',N'''-triacetylfusarinine C metabolic process The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C. go.json N',N'',N'''-triacetylfusarinine C metabolism http://purl.obolibrary.org/obo/GO_1900549 GO:1900548 biolink:BiologicalProcess heme B catabolic process The chemical reactions and pathways resulting in the breakdown of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. MetaCyc:PWY-5874 go.json heme B breakdown|heme B catabolism|heme B degradation|protoheme catabolic process|protoheme degradation http://purl.obolibrary.org/obo/GO_1900548 GO:1900543 biolink:BiologicalProcess negative regulation of purine nucleotide metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process. go.json down regulation of purine metabolic process|down regulation of purine metabolism|down regulation of purine nucleotide metabolic process|down regulation of purine nucleotide metabolism|down-regulation of purine metabolic process|down-regulation of purine metabolism|down-regulation of purine nucleotide metabolic process|down-regulation of purine nucleotide metabolism|downregulation of purine metabolic process|downregulation of purine metabolism|downregulation of purine nucleotide metabolic process|downregulation of purine nucleotide metabolism|inhibition of purine metabolic process|inhibition of purine metabolism|inhibition of purine nucleotide metabolic process|inhibition of purine nucleotide metabolism|negative regulation of purine metabolic process|negative regulation of purine metabolism|negative regulation of purine nucleotide metabolism http://purl.obolibrary.org/obo/GO_1900543 GO:1900542 biolink:BiologicalProcess regulation of purine nucleotide metabolic process Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process. go.json regulation of purine metabolic process|regulation of purine metabolism|regulation of purine nucleotide metabolism http://purl.obolibrary.org/obo/GO_1900542 GO:1900545 biolink:BiologicalProcess obsolete regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of phenotypic switching. go.json regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter True http://purl.obolibrary.org/obo/GO_1900545 GO:1900544 biolink:BiologicalProcess positive regulation of purine nucleotide metabolic process Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. go.json activation of purine metabolic process|activation of purine metabolism|activation of purine nucleotide metabolic process|activation of purine nucleotide metabolism|positive regulation of purine metabolic process|positive regulation of purine metabolism|positive regulation of purine nucleotide metabolism|up regulation of purine metabolic process|up regulation of purine metabolism|up regulation of purine nucleotide metabolic process|up regulation of purine nucleotide metabolism|up-regulation of purine metabolic process|up-regulation of purine metabolism|up-regulation of purine nucleotide metabolic process|up-regulation of purine nucleotide metabolism|upregulation of purine metabolic process|upregulation of purine metabolism|upregulation of purine nucleotide metabolic process|upregulation of purine nucleotide metabolism http://purl.obolibrary.org/obo/GO_1900544 GO:1900541 biolink:BiologicalProcess fumonisin biosynthetic process The chemical reactions and pathways resulting in the formation of fumonisin. go.json fumonisin anabolism|fumonisin biosynthesis|fumonisin formation|fumonisin synthesis http://purl.obolibrary.org/obo/GO_1900541 GO:1900540 biolink:BiologicalProcess fumonisin catabolic process The chemical reactions and pathways resulting in the breakdown of fumonisin. go.json fumonisin breakdown|fumonisin catabolism|fumonisin degradation http://purl.obolibrary.org/obo/GO_1900540 GO:0071659 biolink:BiologicalProcess negative regulation of IP-10 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10. go.json negative regulation of CXCL10 production|negative regulation of chemokine (C-C motif) ligand 10 production http://purl.obolibrary.org/obo/GO_0071659 GO:0071658 biolink:BiologicalProcess regulation of IP-10 production Any process that modulates the frequency, rate, or extent of production of IP-10. go.json regulation of CXCL10 production|regulation of chemokine (C-C motif) ligand 10 production http://purl.obolibrary.org/obo/GO_0071658 GO:0071657 biolink:BiologicalProcess positive regulation of granulocyte colony-stimulating factor production Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor. go.json positive regulation of CSF3 production|positive regulation of G-CSF production|positive regulation of colony stimulating factor 3 (granulocyte) production|positive regulation of filgrastim production|positive regulation of granulocyte colony stimulating factor production|positive regulation of lenograstim production|positive regulation of pluripoietin production http://purl.obolibrary.org/obo/GO_0071657 GO:0071656 biolink:BiologicalProcess negative regulation of granulocyte colony-stimulating factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor. go.json negative regulation of CSF3 production|negative regulation of G-CSF production|negative regulation of colony stimulating factor 3 (granulocyte) production|negative regulation of filgrastim production|negative regulation of granulocyte colony stimulating factor production|negative regulation of lenograstim production|negative regulation of pluripoietin production http://purl.obolibrary.org/obo/GO_0071656 GO:0071655 biolink:BiologicalProcess regulation of granulocyte colony-stimulating factor production Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor. go.json regulation of CSF3 production|regulation of G-CSF production|regulation of colony stimulating factor 3 (granulocyte) production|regulation of filgrastim production|regulation of granulocyte colony stimulating factor production|regulation of lenograstim production|regulation of pluripoietin production http://purl.obolibrary.org/obo/GO_0071655 GO:0071654 biolink:BiologicalProcess positive regulation of chemokine (C-C motif) ligand 1 production Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1. go.json positive regulation of CCL1 production|positive regulation of T cell activation 3 production|positive regulation of TCA-3 production http://purl.obolibrary.org/obo/GO_0071654 GO:0071653 biolink:BiologicalProcess negative regulation of chemokine (C-C motif) ligand 1 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1. go.json negative regulation of CCL1 production|negative regulation of T cell activation 3 production|negative regulation of TCA-3 production http://purl.obolibrary.org/obo/GO_0071653 GO:0071652 biolink:BiologicalProcess regulation of chemokine (C-C motif) ligand 1 production Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1. go.json regulation of CCL1 production|regulation of T cell activation 3 production|regulation of TCA-3 production http://purl.obolibrary.org/obo/GO_0071652 GO:0071651 biolink:BiologicalProcess positive regulation of chemokine (C-C motif) ligand 5 production Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. go.json positive regulation of CCL5 production|positive regulation of RANTES production|positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production http://purl.obolibrary.org/obo/GO_0071651 GO:0071650 biolink:BiologicalProcess negative regulation of chemokine (C-C motif) ligand 5 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. go.json negative regulation of CCL5 production|negative regulation of RANTES production|negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production http://purl.obolibrary.org/obo/GO_0071650 GO:0071682 biolink:CellularComponent endocytic vesicle lumen The volume enclosed by the membrane of an endocytic vesicle. go.json http://purl.obolibrary.org/obo/GO_0071682 GO:0071681 biolink:BiologicalProcess cellular response to indole-3-methanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. go.json cellular response to indole-3-carbinol http://purl.obolibrary.org/obo/GO_0071681 GO:0071680 biolink:BiologicalProcess response to indole-3-methanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. go.json response to indole-3-carbinol http://purl.obolibrary.org/obo/GO_0071680 GO:1900558 biolink:BiologicalProcess austinol metabolic process The chemical reactions and pathways involving austinol. go.json austinol metabolism http://purl.obolibrary.org/obo/GO_1900558 GO:1900557 biolink:BiologicalProcess emericellamide biosynthetic process The chemical reactions and pathways resulting in the formation of emericellamide. go.json emericellamide anabolism|emericellamide biosynthesis|emericellamide formation|emericellamide synthesis http://purl.obolibrary.org/obo/GO_1900557 GO:1900559 biolink:BiologicalProcess austinol catabolic process The chemical reactions and pathways resulting in the breakdown of austinol. go.json austinol breakdown|austinol catabolism|austinol degradation http://purl.obolibrary.org/obo/GO_1900559 GO:1900554 biolink:BiologicalProcess asperfuranone biosynthetic process The chemical reactions and pathways resulting in the formation of asperfuranone. go.json asperfuranone anabolism|asperfuranone biosynthesis|asperfuranone formation|asperfuranone synthesis http://purl.obolibrary.org/obo/GO_1900554 GO:1900553 biolink:BiologicalProcess asperfuranone catabolic process The chemical reactions and pathways resulting in the breakdown of asperfuranone. go.json asperfuranone breakdown|asperfuranone catabolism|asperfuranone degradation http://purl.obolibrary.org/obo/GO_1900553 GO:1900556 biolink:BiologicalProcess emericellamide catabolic process The chemical reactions and pathways resulting in the breakdown of emericellamide. go.json emericellamide breakdown|emericellamide catabolism|emericellamide degradation http://purl.obolibrary.org/obo/GO_1900556 GO:1900555 biolink:BiologicalProcess emericellamide metabolic process The chemical reactions and pathways involving emericellamide. go.json emericellamide metabolism http://purl.obolibrary.org/obo/GO_1900555 GO:1900550 biolink:BiologicalProcess N',N'',N'''-triacetylfusarinine C catabolic process The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C. go.json N',N'',N'''-triacetylfusarinine C breakdown|N',N'',N'''-triacetylfusarinine C catabolism|N',N'',N'''-triacetylfusarinine C degradation http://purl.obolibrary.org/obo/GO_1900550 GO:1900552 biolink:BiologicalProcess asperfuranone metabolic process The chemical reactions and pathways involving asperfuranone. go.json asperfuranone metabolism http://purl.obolibrary.org/obo/GO_1900552 GO:1900551 biolink:BiologicalProcess N',N'',N'''-triacetylfusarinine C biosynthetic process The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C. go.json N',N'',N'''-triacetylfusarinine C anabolism|N',N'',N'''-triacetylfusarinine C biosynthesis|N',N'',N'''-triacetylfusarinine C formation|N',N'',N'''-triacetylfusarinine C synthesis http://purl.obolibrary.org/obo/GO_1900551 GO:0071689 biolink:BiologicalProcess muscle thin filament assembly The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle. go.json http://purl.obolibrary.org/obo/GO_0071689 GO:0071688 biolink:BiologicalProcess striated muscle myosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle. go.json http://purl.obolibrary.org/obo/GO_0071688 GO:0071687 biolink:CellularComponent obsolete horsetail nucleus leading edge OBSOLETE. The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe. go.json True http://purl.obolibrary.org/obo/GO_0071687 GO:0071686 biolink:CellularComponent obsolete horsetail nucleus OBSOLETE. The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe. go.json True http://purl.obolibrary.org/obo/GO_0071686 GO:0071685 biolink:CellularComponent NADH dehydrogenase complex (plastoquinone) An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids. go.json http://purl.obolibrary.org/obo/GO_0071685 GO:0071684 biolink:BiologicalProcess organism emergence from protective structure The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case. go.json http://purl.obolibrary.org/obo/GO_0071684 GO:0071683 biolink:CellularComponent sensory dendrite A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron. go.json http://purl.obolibrary.org/obo/GO_0071683 GO:0071671 biolink:BiologicalProcess regulation of smooth muscle cell chemotaxis Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. go.json http://purl.obolibrary.org/obo/GO_0071671 GO:0071670 biolink:BiologicalProcess smooth muscle cell chemotaxis The directed movement of a smooth muscle cell in response to an external stimulus. go.json http://purl.obolibrary.org/obo/GO_0071670 GO:1900569 biolink:BiologicalProcess chanoclavine-I aldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde. Chanoclavine-I aldehyde is at a branching point in the biosynthetic pathways of fumigaclavine C and ergotamine. go.json chanoclavine-I aldehyde anabolism|chanoclavine-I aldehyde biosynthesis|chanoclavine-I aldehyde formation|chanoclavine-I aldehyde synthesis http://purl.obolibrary.org/obo/GO_1900569 GO:1900568 biolink:BiologicalProcess obsolete chanoclavine-I aldehyde catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde. go.json chanoclavine-I aldehyde breakdown|chanoclavine-I aldehyde catabolism|chanoclavine-I aldehyde degradation True http://purl.obolibrary.org/obo/GO_1900568 GO:1900565 biolink:BiologicalProcess obsolete chanoclavine-I catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chanoclavine-I. go.json chanoclavine-I breakdown|chanoclavine-I catabolism|chanoclavine-I degradation True http://purl.obolibrary.org/obo/GO_1900565 GO:1900564 biolink:BiologicalProcess chanoclavine-I metabolic process The chemical reactions and pathways involving chanoclavine-I. go.json chanoclavine-I metabolism http://purl.obolibrary.org/obo/GO_1900564 GO:1900567 biolink:BiologicalProcess chanoclavine-I aldehyde metabolic process The chemical reactions and pathways involving chanoclavine-I aldehyde. go.json chanoclavine-I aldehyde metabolism http://purl.obolibrary.org/obo/GO_1900567 GO:1900566 biolink:BiologicalProcess obsolete chanoclavine-I biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of chanoclavine-I. go.json chanoclavine-I anabolism|chanoclavine-I biosynthesis|chanoclavine-I formation|chanoclavine-I synthesis True http://purl.obolibrary.org/obo/GO_1900566 GO:1900561 biolink:BiologicalProcess dehydroaustinol metabolic process The chemical reactions and pathways involving dehydroaustinol. go.json dehydroaustinol metabolism http://purl.obolibrary.org/obo/GO_1900561 GO:1900560 biolink:BiologicalProcess austinol biosynthetic process The chemical reactions and pathways resulting in the formation of austinol. go.json austinol anabolism|austinol biosynthesis|austinol formation|austinol synthesis http://purl.obolibrary.org/obo/GO_1900560 GO:1900563 biolink:BiologicalProcess dehydroaustinol biosynthetic process The chemical reactions and pathways resulting in the formation of dehydroaustinol. go.json dehydroaustinol anabolism|dehydroaustinol biosynthesis|dehydroaustinol formation|dehydroaustinol synthesis http://purl.obolibrary.org/obo/GO_1900563 GO:1900562 biolink:BiologicalProcess dehydroaustinol catabolic process The chemical reactions and pathways resulting in the breakdown of dehydroaustinol. go.json dehydroaustinol breakdown|dehydroaustinol catabolism|dehydroaustinol degradation http://purl.obolibrary.org/obo/GO_1900562 GO:1900570 biolink:BiologicalProcess diorcinol metabolic process The chemical reactions and pathways involving diorcinol. go.json diorcinol metabolism http://purl.obolibrary.org/obo/GO_1900570 GO:0071679 biolink:BiologicalProcess commissural neuron axon guidance The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. go.json commissural neuron axon pathfinding http://purl.obolibrary.org/obo/GO_0071679 GO:0071678 biolink:BiologicalProcess olfactory bulb axon guidance The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues. go.json olfactory bulb axon pathfinding http://purl.obolibrary.org/obo/GO_0071678 GO:0071677 biolink:BiologicalProcess positive regulation of mononuclear cell migration Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. go.json activation of mononuclear cell migration|stimulation of mononuclear cell migration|up regulation of mononuclear cell migration|up-regulation of mononuclear cell migration|upregulation of mononuclear cell migration http://purl.obolibrary.org/obo/GO_0071677 GO:0071676 biolink:BiologicalProcess negative regulation of mononuclear cell migration Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. go.json down regulation of mononuclear cell migration|down-regulation of mononuclear cell migration|downregulation of mononuclear cell migration|inhibition of mononuclear cell migration http://purl.obolibrary.org/obo/GO_0071676 GO:0071675 biolink:BiologicalProcess regulation of mononuclear cell migration Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0071675 GO:0071674 biolink:BiologicalProcess mononuclear cell migration The movement of a mononuclear cell within or between different tissues and organs of the body. go.json http://purl.obolibrary.org/obo/GO_0071674 GO:0071673 biolink:BiologicalProcess positive regulation of smooth muscle cell chemotaxis Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis. go.json activation of smooth muscle cell chemotaxis|stimulation of smooth muscle cell chemotaxis|up regulation of smooth muscle cell chemotaxis|up-regulation of smooth muscle cell chemotaxis|upregulation of smooth muscle cell chemotaxis http://purl.obolibrary.org/obo/GO_0071673 GO:0071672 biolink:BiologicalProcess negative regulation of smooth muscle cell chemotaxis Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis. go.json down regulation of smooth muscle cell chemotaxis|down-regulation of smooth muscle cell chemotaxis|downregulation of smooth muscle cell chemotaxis|inhibition of smooth muscle cell chemotaxis http://purl.obolibrary.org/obo/GO_0071672 GO:1900579 biolink:BiologicalProcess (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol. go.json (17Z)-protosta-17(20),24-dien-3beta-ol metabolism http://purl.obolibrary.org/obo/GO_1900579 GO:1900576 biolink:BiologicalProcess gerfelin metabolic process The chemical reactions and pathways involving gerfelin. go.json gerfelin metabolism http://purl.obolibrary.org/obo/GO_1900576 GO:1900575 biolink:BiologicalProcess emodin biosynthetic process The chemical reactions and pathways resulting in the formation of emodin. go.json emodin anabolism|emodin biosynthesis|emodin formation|emodin synthesis http://purl.obolibrary.org/obo/GO_1900575 GO:1900578 biolink:BiologicalProcess gerfelin biosynthetic process The chemical reactions and pathways resulting in the formation of gerfelin. go.json gerfelin anabolism|gerfelin biosynthesis|gerfelin formation|gerfelin synthesis http://purl.obolibrary.org/obo/GO_1900578 GO:1900577 biolink:BiologicalProcess gerfelin catabolic process The chemical reactions and pathways resulting in the breakdown of gerfelin. go.json gerfelin breakdown|gerfelin catabolism|gerfelin degradation http://purl.obolibrary.org/obo/GO_1900577 GO:1900572 biolink:BiologicalProcess diorcinol biosynthetic process The chemical reactions and pathways resulting in the formation of diorcinol. go.json diorcinol anabolism|diorcinol biosynthesis|diorcinol formation|diorcinol synthesis http://purl.obolibrary.org/obo/GO_1900572 GO:1900571 biolink:BiologicalProcess diorcinol catabolic process The chemical reactions and pathways resulting in the breakdown of diorcinol. go.json diorcinol breakdown|diorcinol catabolism|diorcinol degradation http://purl.obolibrary.org/obo/GO_1900571 GO:1900574 biolink:BiologicalProcess emodin catabolic process The chemical reactions and pathways resulting in the breakdown of emodin. go.json emodin breakdown|emodin catabolism|emodin degradation http://purl.obolibrary.org/obo/GO_1900574 GO:1900573 biolink:BiologicalProcess emodin metabolic process The chemical reactions and pathways involving emodin. go.json emodin metabolism http://purl.obolibrary.org/obo/GO_1900573 GO:1900581 biolink:BiologicalProcess (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol. go.json (17Z)-protosta-17(20),24-dien-3beta-ol anabolism|(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis|(17Z)-protosta-17(20),24-dien-3beta-ol formation|(17Z)-protosta-17(20),24-dien-3beta-ol synthesis http://purl.obolibrary.org/obo/GO_1900581 GO:1900580 biolink:BiologicalProcess (17Z)-protosta-17(20),24-dien-3beta-ol catabolic process The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol. go.json (17Z)-protosta-17(20),24-dien-3beta-ol breakdown|(17Z)-protosta-17(20),24-dien-3beta-ol catabolism|(17Z)-protosta-17(20),24-dien-3beta-ol degradation http://purl.obolibrary.org/obo/GO_1900580 GO:0071693 biolink:BiologicalProcess protein transport within extracellular region The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0071693 GO:0071692 biolink:BiologicalProcess protein localization to extracellular region Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. go.json protein localisation in extracellular region|protein localization in extracellular region http://purl.obolibrary.org/obo/GO_0071692 GO:0071691 biolink:BiologicalProcess cardiac muscle thin filament assembly The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle. go.json http://purl.obolibrary.org/obo/GO_0071691 GO:0071690 biolink:BiologicalProcess cardiac muscle myosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle. go.json http://purl.obolibrary.org/obo/GO_0071690 GO:1900587 biolink:BiologicalProcess arugosin biosynthetic process The chemical reactions and pathways resulting in the formation of arugosin. go.json arugosin anabolism|arugosin biosynthesis|arugosin formation|arugosin synthesis http://purl.obolibrary.org/obo/GO_1900587 GO:1900586 biolink:BiologicalProcess arugosin catabolic process The chemical reactions and pathways resulting in the breakdown of arugosin. go.json arugosin breakdown|arugosin catabolism|arugosin degradation http://purl.obolibrary.org/obo/GO_1900586 GO:1900589 biolink:BiologicalProcess violaceol I catabolic process The chemical reactions and pathways resulting in the breakdown of violaceol I. go.json violaceol I breakdown|violaceol I catabolism|violaceol I degradation http://purl.obolibrary.org/obo/GO_1900589 GO:1900588 biolink:BiologicalProcess violaceol I metabolic process The chemical reactions and pathways involving violaceol I. go.json violaceol I metabolism http://purl.obolibrary.org/obo/GO_1900588 GO:1900583 biolink:BiologicalProcess o-orsellinic acid catabolic process The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid. go.json o-orsellinic acid breakdown|o-orsellinic acid catabolism|o-orsellinic acid degradation http://purl.obolibrary.org/obo/GO_1900583 GO:1900582 biolink:BiologicalProcess o-orsellinic acid metabolic process The chemical reactions and pathways involving o-orsellinic acid. go.json o-orsellinic acid metabolism http://purl.obolibrary.org/obo/GO_1900582 GO:1900585 biolink:BiologicalProcess arugosin metabolic process The chemical reactions and pathways involving arugosin. go.json arugosin metabolism http://purl.obolibrary.org/obo/GO_1900585 GO:1900584 biolink:BiologicalProcess o-orsellinic acid biosynthetic process The chemical reactions and pathways resulting in the formation of o-orsellinic acid. go.json o-orsellinic acid anabolism|o-orsellinic acid biosynthesis|o-orsellinic acid formation|o-orsellinic acid synthesis http://purl.obolibrary.org/obo/GO_1900584 GO:1900590 biolink:BiologicalProcess violaceol I biosynthetic process The chemical reactions and pathways resulting in the formation of violaceol I. go.json violaceol I anabolism|violaceol I biosynthesis|violaceol I formation|violaceol I synthesis http://purl.obolibrary.org/obo/GO_1900590 GO:1900592 biolink:BiologicalProcess violaceol II catabolic process The chemical reactions and pathways resulting in the breakdown of violaceol II. go.json violaceol II breakdown|violaceol II catabolism|violaceol II degradation http://purl.obolibrary.org/obo/GO_1900592 GO:1900591 biolink:BiologicalProcess violaceol II metabolic process The chemical reactions and pathways involving violaceol II. go.json violaceol II metabolism http://purl.obolibrary.org/obo/GO_1900591 GO:0071699 biolink:BiologicalProcess olfactory placode morphogenesis The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. go.json http://purl.obolibrary.org/obo/GO_0071699 GO:0071698 biolink:BiologicalProcess olfactory placode development The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. go.json http://purl.obolibrary.org/obo/GO_0071698 GO:0071697 biolink:BiologicalProcess ectodermal placode morphogenesis The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. go.json http://purl.obolibrary.org/obo/GO_0071697 GO:0071696 biolink:BiologicalProcess ectodermal placode development The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. go.json http://purl.obolibrary.org/obo/GO_0071696 GO:0071695 biolink:BiologicalProcess anatomical structure maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. go.json http://purl.obolibrary.org/obo/GO_0071695 GO:0071694 biolink:BiologicalProcess maintenance of protein location in extracellular region Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere. go.json http://purl.obolibrary.org/obo/GO_0071694 GO:1900914 biolink:BiologicalProcess regulation of octadecene biosynthetic process Any process that modulates the frequency, rate or extent of octadecene biosynthetic process. go.json regulation of 1-octadecene biosynthetic process|regulation of octadecene anabolism|regulation of octadecene biosynthesis|regulation of octadecene formation|regulation of octadecene synthesis http://purl.obolibrary.org/obo/GO_1900914 GO:1900913 biolink:BiologicalProcess positive regulation of olefin biosynthetic process Any process that activates or increases the frequency, rate or extent of olefin biosynthetic process. go.json activation of olefin anabolism|activation of olefin biosynthesis|activation of olefin biosynthetic process|activation of olefin formation|activation of olefin synthesis|positive regulation of olefin anabolism|positive regulation of olefin biosynthesis|positive regulation of olefin formation|positive regulation of olefin synthesis|up regulation of olefin anabolism|up regulation of olefin biosynthesis|up regulation of olefin biosynthetic process|up regulation of olefin formation|up regulation of olefin synthesis|up-regulation of olefin anabolism|up-regulation of olefin biosynthesis|up-regulation of olefin biosynthetic process|up-regulation of olefin formation|up-regulation of olefin synthesis|upregulation of olefin anabolism|upregulation of olefin biosynthesis|upregulation of olefin biosynthetic process|upregulation of olefin formation|upregulation of olefin synthesis http://purl.obolibrary.org/obo/GO_1900913 GO:1900916 biolink:BiologicalProcess positive regulation of octadecene biosynthetic process Any process that activates or increases the frequency, rate or extent of octadecene biosynthetic process. go.json activation of 1-octadecene biosynthetic process|activation of octadecene anabolism|activation of octadecene biosynthesis|activation of octadecene biosynthetic process|activation of octadecene formation|activation of octadecene synthesis|positive regulation of 1-octadecene biosynthetic process|positive regulation of octadecene anabolism|positive regulation of octadecene biosynthesis|positive regulation of octadecene formation|positive regulation of octadecene synthesis|up regulation of 1-octadecene biosynthetic process|up regulation of octadecene anabolism|up regulation of octadecene biosynthesis|up regulation of octadecene biosynthetic process|up regulation of octadecene formation|up regulation of octadecene synthesis|up-regulation of 1-octadecene biosynthetic process|up-regulation of octadecene anabolism|up-regulation of octadecene biosynthesis|up-regulation of octadecene biosynthetic process|up-regulation of octadecene formation|up-regulation of octadecene synthesis|upregulation of 1-octadecene biosynthetic process|upregulation of octadecene anabolism|upregulation of octadecene biosynthesis|upregulation of octadecene biosynthetic process|upregulation of octadecene formation|upregulation of octadecene synthesis http://purl.obolibrary.org/obo/GO_1900916 GO:0022871 biolink:MolecularActivity protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. EC:2.7.1.206|RHEA:49296 go.json sorbose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022871 GO:1900915 biolink:BiologicalProcess negative regulation of octadecene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process. go.json down regulation of 1-octadecene biosynthetic process|down regulation of octadecene anabolism|down regulation of octadecene biosynthesis|down regulation of octadecene biosynthetic process|down regulation of octadecene formation|down regulation of octadecene synthesis|down-regulation of 1-octadecene biosynthetic process|down-regulation of octadecene anabolism|down-regulation of octadecene biosynthesis|down-regulation of octadecene biosynthetic process|down-regulation of octadecene formation|down-regulation of octadecene synthesis|downregulation of 1-octadecene biosynthetic process|downregulation of octadecene anabolism|downregulation of octadecene biosynthesis|downregulation of octadecene biosynthetic process|downregulation of octadecene formation|downregulation of octadecene synthesis|inhibition of 1-octadecene biosynthetic process|inhibition of octadecene anabolism|inhibition of octadecene biosynthesis|inhibition of octadecene biosynthetic process|inhibition of octadecene formation|inhibition of octadecene synthesis|negative regulation of 1-octadecene biosynthetic process|negative regulation of octadecene anabolism|negative regulation of octadecene biosynthesis|negative regulation of octadecene formation|negative regulation of octadecene synthesis http://purl.obolibrary.org/obo/GO_1900915 GO:0022870 biolink:MolecularActivity protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json mannose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022870 GO:1900910 biolink:BiologicalProcess positive regulation of olefin metabolic process Any process that activates or increases the frequency, rate or extent of olefin metabolic process. go.json activation of olefin metabolic process|activation of olefin metabolism|positive regulation of olefin metabolism|up regulation of olefin metabolic process|up regulation of olefin metabolism|up-regulation of olefin metabolic process|up-regulation of olefin metabolism|upregulation of olefin metabolic process|upregulation of olefin metabolism http://purl.obolibrary.org/obo/GO_1900910 GO:0022873 biolink:MolecularActivity protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json maltose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022873 GO:0022872 biolink:MolecularActivity protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json mannitol PTS transporter activity http://purl.obolibrary.org/obo/GO_0022872 GO:0007239 biolink:BiologicalProcess obsolete activation of Hog1 OBSOLETE. (Was not defined before being made obsolete). go.json activation of Hog1 True http://purl.obolibrary.org/obo/GO_0007239 GO:1900912 biolink:BiologicalProcess negative regulation of olefin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process. go.json down regulation of olefin anabolism|down regulation of olefin biosynthesis|down regulation of olefin biosynthetic process|down regulation of olefin formation|down regulation of olefin synthesis|down-regulation of olefin anabolism|down-regulation of olefin biosynthesis|down-regulation of olefin biosynthetic process|down-regulation of olefin formation|down-regulation of olefin synthesis|downregulation of olefin anabolism|downregulation of olefin biosynthesis|downregulation of olefin biosynthetic process|downregulation of olefin formation|downregulation of olefin synthesis|inhibition of olefin anabolism|inhibition of olefin biosynthesis|inhibition of olefin biosynthetic process|inhibition of olefin formation|inhibition of olefin synthesis|negative regulation of olefin anabolism|negative regulation of olefin biosynthesis|negative regulation of olefin formation|negative regulation of olefin synthesis http://purl.obolibrary.org/obo/GO_1900912 GO:0022875 biolink:MolecularActivity protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json galactitol PTS transporter activity http://purl.obolibrary.org/obo/GO_0022875 GO:0007238 biolink:BiologicalProcess obsolete activation of Pbs2 OBSOLETE. (Was not defined before being made obsolete). go.json activation of Pbs2 True http://purl.obolibrary.org/obo/GO_0007238 GO:1900911 biolink:BiologicalProcess regulation of olefin biosynthetic process Any process that modulates the frequency, rate or extent of olefin biosynthetic process. go.json regulation of olefin anabolism|regulation of olefin biosynthesis|regulation of olefin formation|regulation of olefin synthesis http://purl.obolibrary.org/obo/GO_1900911 GO:0022874 biolink:MolecularActivity protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json cellobiose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022874 GO:0007237 biolink:BiologicalProcess obsolete activation of Ssk2/Ssk22 proteins OBSOLETE. (Was not defined before being made obsolete). go.json activation of Ssk2/Ssk22 proteins True http://purl.obolibrary.org/obo/GO_0007237 GO:0007236 biolink:BiologicalProcess obsolete activation of Ssk1 protein OBSOLETE. (Was not defined before being made obsolete). go.json activation of Ssk1 protein True http://purl.obolibrary.org/obo/GO_0007236 GO:0046844 biolink:BiologicalProcess chorion micropyle formation Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization. go.json http://purl.obolibrary.org/obo/GO_0046844 GO:0046843 biolink:BiologicalProcess dorsal appendage formation Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration. go.json http://purl.obolibrary.org/obo/GO_0046843 GO:0007235 biolink:BiologicalProcess obsolete activation of Ypd1 protein OBSOLETE. (Was not defined before being made obsolete). go.json activation of Ypd1 protein True http://purl.obolibrary.org/obo/GO_0007235 GO:0046842 biolink:BiologicalProcess trisporic acid biosynthetic process The chemical reactions and pathways resulting in the formation of trisporic acid. go.json trisporic acid anabolism|trisporic acid biosynthesis|trisporic acid formation|trisporic acid synthesis http://purl.obolibrary.org/obo/GO_0046842 GO:0007234 biolink:BiologicalProcess osmosensory signaling via phosphorelay pathway The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. go.json osmolarity sensing via two-component system|osmolarity signaling pathway via two-component system|osmolarity signalling pathway via two-component system|osmosensory signaling pathway via two-component system|osmosensory signalling pathway via two-component system|signal transduction during osmotic stress via two-component system http://purl.obolibrary.org/obo/GO_0007234 GO:0046841 biolink:BiologicalProcess trisporic acid metabolic process The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota. go.json trisporic acid metabolism http://purl.obolibrary.org/obo/GO_0046841 GO:0007233 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007233 GO:0007232 biolink:BiologicalProcess osmosensory signaling pathway via Sho1 osmosensor The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system. go.json osmosensory signalling pathway via Sho1 osmosensor|signal transduction during osmotic stress via Sho1 osmosensor http://purl.obolibrary.org/obo/GO_0007232 GO:0046840 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046840 GO:0007231 biolink:BiologicalProcess osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change. go.json osmolarity sensing|osmolarity sensing signaling pathway|osmolarity sensing signalling pathway|osmosensory signal transduction|osmosensory signalling pathway|signal transduction during osmotic stress http://purl.obolibrary.org/obo/GO_0007231 GO:0007230 biolink:BiologicalProcess obsolete calcium-o-sensing receptor pathway OBSOLETE. (Was not defined before being made obsolete). go.json calcium-o-sensing receptor pathway True http://purl.obolibrary.org/obo/GO_0007230 GO:0071808 biolink:CellularComponent satellite fibril An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section). go.json http://purl.obolibrary.org/obo/GO_0071808 GO:0071807 biolink:BiologicalProcess replication fork arrest involved in DNA replication termination A replication fork arrest process that contributes to the termination of DNA replication. go.json http://purl.obolibrary.org/obo/GO_0071807 GO:0071806 biolink:BiologicalProcess protein transmembrane transport The process in which a protein is transported across a membrane. go.json protein membrane transport http://purl.obolibrary.org/obo/GO_0071806 GO:0046849 biolink:BiologicalProcess bone remodeling The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. Wikipedia:Bone_remodeling go.json bone remodelling http://purl.obolibrary.org/obo/GO_0046849 GO:0071805 biolink:BiologicalProcess potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other. go.json high affinity potassium ion import|high affinity potassium ion uptake|high-affinity potassium ion import|high-affinity potassium ion uptake|potassium ion membrane transport http://purl.obolibrary.org/obo/GO_0071805 GO:0046848 biolink:MolecularActivity hydroxyapatite binding Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin. go.json hydroxylapatite binding http://purl.obolibrary.org/obo/GO_0046848 GO:0071804 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071804 GO:0071803 biolink:BiologicalProcess positive regulation of podosome assembly Any process that activates or increases the rate or extent of podosome assembly. go.json activation of podosome assembly|stimulation of podosome assembly|up regulation of podosome assembly|up-regulation of podosome assembly|upregulation of podosome assembly http://purl.obolibrary.org/obo/GO_0071803 GO:0046847 biolink:BiologicalProcess filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. go.json filopodia biosynthesis|filopodia formation|filopodium formation http://purl.obolibrary.org/obo/GO_0046847 GO:0071802 biolink:BiologicalProcess negative regulation of podosome assembly Any process that stops, prevents or reduces the rate or extent of podosome assembly. go.json down regulation of podosome assembly|down-regulation of podosome assembly|downregulation of podosome assembly|inhibition of podosome assembly http://purl.obolibrary.org/obo/GO_0071802 GO:0046846 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046846 GO:0046845 biolink:BiologicalProcess branched duct epithelial cell fate determination, open tracheal system Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode. go.json branch cell fate determination http://purl.obolibrary.org/obo/GO_0046845 GO:0071801 biolink:BiologicalProcess regulation of podosome assembly Any process that modulates the frequency, rate or extent of podosome assembly. go.json http://purl.obolibrary.org/obo/GO_0071801 GO:0071800 biolink:BiologicalProcess podosome assembly The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. go.json http://purl.obolibrary.org/obo/GO_0071800 GO:0022877 biolink:MolecularActivity protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json fructose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022877 GO:0022876 biolink:MolecularActivity protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json galactosamine PTS transporter activity http://purl.obolibrary.org/obo/GO_0022876 GO:0022879 biolink:MolecularActivity protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json trehalose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022879 GO:0022878 biolink:MolecularActivity protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. MetaCyc:SUCROSEPHOSPHO-RXN|RHEA:49236 go.json sucrose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022878 GO:1900918 biolink:BiologicalProcess negative regulation of octadecene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process. go.json down regulation of octadecene metabolic process|down regulation of octadecene metabolism|down-regulation of octadecene metabolic process|down-regulation of octadecene metabolism|downregulation of octadecene metabolic process|downregulation of octadecene metabolism|inhibition of octadecene metabolic process|inhibition of octadecene metabolism|negative regulation of octadecene metabolism http://purl.obolibrary.org/obo/GO_1900918 GO:1900917 biolink:BiologicalProcess regulation of octadecene metabolic process Any process that modulates the frequency, rate or extent of octadecene metabolic process. go.json regulation of octadecene metabolism http://purl.obolibrary.org/obo/GO_1900917 GO:1900919 biolink:BiologicalProcess positive regulation of octadecene metabolic process Any process that activates or increases the frequency, rate or extent of octadecene metabolic process. go.json activation of octadecene metabolic process|activation of octadecene metabolism|positive regulation of octadecene metabolism|up regulation of octadecene metabolic process|up regulation of octadecene metabolism|up-regulation of octadecene metabolic process|up-regulation of octadecene metabolism|upregulation of octadecene metabolic process|upregulation of octadecene metabolism http://purl.obolibrary.org/obo/GO_1900919 GO:1900925 biolink:BiologicalProcess positive regulation of glycine import across plasma membrane Any process that activates or increases the frequency, rate or extent of glycine import. go.json activation of glycine import|positive regulation of glycine import|up regulation of glycine import|up-regulation of glycine import|upregulation of glycine import http://purl.obolibrary.org/obo/GO_1900925 GO:1900924 biolink:BiologicalProcess negative regulation of glycine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell. go.json down regulation of glycine import|down-regulation of glycine import|downregulation of glycine import|inhibition of glycine import|negative regulation of glycine import http://purl.obolibrary.org/obo/GO_1900924 GO:1900927 biolink:BiologicalProcess negative regulation of L-threonine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import into cell. go.json down regulation of L-threonine import|down regulation of L-threonine uptake|down-regulation of L-threonine import|down-regulation of L-threonine uptake|downregulation of L-threonine import|downregulation of L-threonine uptake|inhibition of L-threonine import|inhibition of L-threonine uptake|negative regulation of L-threonine uptake http://purl.obolibrary.org/obo/GO_1900927 GO:1900926 biolink:BiologicalProcess regulation of L-threonine import across plasma membrane Any process that modulates the frequency, rate or extent of L-threonine import into cell. go.json regulation of L-threonine import|regulation of L-threonine uptake http://purl.obolibrary.org/obo/GO_1900926 GO:1900921 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900921 GO:1900920 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900920 GO:1900923 biolink:BiologicalProcess regulation of glycine import across plasma membrane Any process that modulates the frequency, rate or extent of glycine import into a cell. go.json regulation of glycine import http://purl.obolibrary.org/obo/GO_1900923 GO:0007249 biolink:BiologicalProcess canonical NF-kappaB signal transduction The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). go.json I-kappaB kinase/NF-kappaB cascade|I-kappaB kinase/NF-kappaB signal transduction|I-kappaB kinase/NF-kappaB signaling|NF-kappaB cascade|canonical NF-kappaB signaling cascade|p50-dependent NF-kappaB signaling http://purl.obolibrary.org/obo/GO_0007249 GO:0007248 biolink:BiologicalProcess obsolete nuclear translocation of MAPK (mating sensu Saccharomyces) OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces. go.json nuclear translocation of MAPK (mating sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007248 GO:1900922 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900922 GO:0046855 biolink:BiologicalProcess obsolete inositol phosphate dephosphorylation OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol. go.json myo-inositol phosphate dephosphorylation True http://purl.obolibrary.org/obo/GO_0046855 GO:0007247 biolink:BiologicalProcess obsolete activation of MAPK (mating sensu Saccharomyces) OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces. go.json activation of MAPK (mating sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007247 GO:0007246 biolink:BiologicalProcess obsolete activation of MAPKK (mating sensu Saccharomyces) OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces. go.json activation of MAPKK (mating sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007246 GO:0046854 biolink:BiologicalProcess phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. go.json PIP biosynthesis|PtdInsP biosynthesis|phosphatidylinositol phosphate biosynthesis|phosphatidylinositol phosphate phosphorylation|phosphatidylinositol phosphorylation|phosphoinositide phosphorylation http://purl.obolibrary.org/obo/GO_0046854 GO:0007245 biolink:BiologicalProcess obsolete activation of MAPKKK (mating sensu Saccharomyces) OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces. go.json activation of MAPKKK (mating sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007245 GO:0046853 biolink:BiologicalProcess obsolete inositol or phosphatidylinositol phosphorylation OBSOLETE. The process of introducing a phosphate group into inositol or a phosphatidylinositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms. go.json inositol and derivative phosphorylation|inositol or phosphatidylinositol phosphorylation|myo-inositol and derivative phosphorylation|myo-inositol or phosphatidyl-myo-inositol phosphorylation True http://purl.obolibrary.org/obo/GO_0046853 GO:0007244 biolink:BiologicalProcess obsolete MAPKKK cascade (mating sensu Saccharomyces) OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces. go.json MAPKKK cascade (mating sensu Saccharomyces) True http://purl.obolibrary.org/obo/GO_0007244 GO:0046852 biolink:BiologicalProcess positive regulation of bone remodeling Any process that activates or increases the frequency, rate or extent of bone remodeling. go.json activation of bone remodeling|positive regulation of bone remodelling|stimulation of bone remodeling|up regulation of bone remodeling|up-regulation of bone remodeling|upregulation of bone remodeling http://purl.obolibrary.org/obo/GO_0046852 GO:0007243 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007243 GO:0046851 biolink:BiologicalProcess negative regulation of bone remodeling Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. go.json down regulation of bone remodeling|down-regulation of bone remodeling|downregulation of bone remodeling|inhibition of bone remodeling|negative regulation of bone remodelling http://purl.obolibrary.org/obo/GO_0046851 GO:0046850 biolink:BiologicalProcess regulation of bone remodeling Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. go.json regulation of bone remodelling http://purl.obolibrary.org/obo/GO_0046850 GO:0007242 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007242 GO:0007241 biolink:BiologicalProcess obsolete inactivation of Hog1 OBSOLETE. (Was not defined before being made obsolete). go.json inactivation of Hog1 True http://purl.obolibrary.org/obo/GO_0007241 GO:0007240 biolink:BiologicalProcess obsolete nuclear translocation of Hog1 OBSOLETE. (Was not defined before being made obsolete). go.json nuclear translocation of Hog1 True http://purl.obolibrary.org/obo/GO_0007240 GO:0007250 biolink:BiologicalProcess activation of NF-kappaB-inducing kinase activity The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. go.json activation of NIK activity|positive regulation of NF-kappaB-inducing kinase activity http://purl.obolibrary.org/obo/GO_0007250 gocheck_do_not_annotate GO:0046859 biolink:CellularComponent hydrogenosomal membrane The lipid bilayer surrounding a hydrogenosome. go.json hydrogenosome membrane http://purl.obolibrary.org/obo/GO_0046859 GO:0046858 biolink:CellularComponent chlorosome A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate. Wikipedia:Chlorosome go.json http://purl.obolibrary.org/obo/GO_0046858 GO:0046857 biolink:MolecularActivity oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. EC:1.7.1.- go.json http://purl.obolibrary.org/obo/GO_0046857 GO:0046856 biolink:BiologicalProcess phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol. go.json PIP catabolism|PtdInsP catabolism|PtdInsP dephosphorylation|phosphatidylinositol phosphate catabolic process|phosphatidylinositol phosphate dephosphorylation|phosphoinositide dephosphorylation http://purl.obolibrary.org/obo/GO_0046856 GO:0022866 biolink:MolecularActivity obsolete transmembrane 1-electron transfer carrier OBSOLETE. Enables transfer of one electron across a membrane. go.json transmembrane one-electron transfer carrier True http://purl.obolibrary.org/obo/GO_0022866 GO:0022865 biolink:MolecularActivity obsolete transmembrane electron transfer carrier OBSOLETE. Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics. TC:5 go.json True http://purl.obolibrary.org/obo/GO_0022865 GO:0022867 biolink:MolecularActivity obsolete transmembrane 2-electron transfer carrier OBSOLETE. Enables transfer of two electrons across a membrane. go.json transmembrane two-electron transfer carrier True http://purl.obolibrary.org/obo/GO_0022867 GO:1900929 biolink:BiologicalProcess regulation of L-tyrosine import across plasma membrane Any process that modulates the frequency, rate or extent of L-tyrosine import into the cell. go.json regulation of L-tyrosine import|regulation of L-tyrosine uptake http://purl.obolibrary.org/obo/GO_1900929 GO:1900928 biolink:BiologicalProcess positive regulation of L-threonine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-threonine import into cell. go.json activation of L-threonine import|activation of L-threonine uptake|positive regulation of L-threonine import|positive regulation of L-threonine uptake|up regulation of L-threonine import|up regulation of L-threonine uptake|up-regulation of L-threonine import|up-regulation of L-threonine uptake|upregulation of L-threonine import|upregulation of L-threonine uptake http://purl.obolibrary.org/obo/GO_1900928 GO:0022869 biolink:MolecularActivity protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json lactose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022869 GO:1900936 biolink:BiologicalProcess negative regulation of nonadec-1-ene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process. go.json down regulation of nonadec-1-ene anabolism|down regulation of nonadec-1-ene biosynthesis|down regulation of nonadec-1-ene biosynthetic process|down regulation of nonadec-1-ene formation|down regulation of nonadec-1-ene synthesis|down-regulation of nonadec-1-ene anabolism|down-regulation of nonadec-1-ene biosynthesis|down-regulation of nonadec-1-ene biosynthetic process|down-regulation of nonadec-1-ene formation|down-regulation of nonadec-1-ene synthesis|downregulation of nonadec-1-ene anabolism|downregulation of nonadec-1-ene biosynthesis|downregulation of nonadec-1-ene biosynthetic process|downregulation of nonadec-1-ene formation|downregulation of nonadec-1-ene synthesis|inhibition of nonadec-1-ene anabolism|inhibition of nonadec-1-ene biosynthesis|inhibition of nonadec-1-ene biosynthetic process|inhibition of nonadec-1-ene formation|inhibition of nonadec-1-ene synthesis|negative regulation of nonadec-1-ene anabolism|negative regulation of nonadec-1-ene biosynthesis|negative regulation of nonadec-1-ene formation|negative regulation of nonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900936 GO:1900935 biolink:BiologicalProcess regulation of nonadec-1-ene biosynthetic process Any process that modulates the frequency, rate or extent of nonadec-1-ene biosynthetic process. go.json regulation of nonadec-1-ene anabolism|regulation of nonadec-1-ene biosynthesis|regulation of nonadec-1-ene formation|regulation of nonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900935 GO:1900938 biolink:BiologicalProcess regulation of (Z)-nonadeca-1,14-diene metabolic process Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process. go.json regulation of (Z)-nonadeca-1,14-diene metabolism http://purl.obolibrary.org/obo/GO_1900938 GO:1900937 biolink:BiologicalProcess positive regulation of nonadec-1-ene biosynthetic process Any process that activates or increases the frequency, rate or extent of nonadec-1-ene biosynthetic process. go.json activation of nonadec-1-ene anabolism|activation of nonadec-1-ene biosynthesis|activation of nonadec-1-ene biosynthetic process|activation of nonadec-1-ene formation|activation of nonadec-1-ene synthesis|positive regulation of nonadec-1-ene anabolism|positive regulation of nonadec-1-ene biosynthesis|positive regulation of nonadec-1-ene formation|positive regulation of nonadec-1-ene synthesis|up regulation of nonadec-1-ene anabolism|up regulation of nonadec-1-ene biosynthesis|up regulation of nonadec-1-ene biosynthetic process|up regulation of nonadec-1-ene formation|up regulation of nonadec-1-ene synthesis|up-regulation of nonadec-1-ene anabolism|up-regulation of nonadec-1-ene biosynthesis|up-regulation of nonadec-1-ene biosynthetic process|up-regulation of nonadec-1-ene formation|up-regulation of nonadec-1-ene synthesis|upregulation of nonadec-1-ene anabolism|upregulation of nonadec-1-ene biosynthesis|upregulation of nonadec-1-ene biosynthetic process|upregulation of nonadec-1-ene formation|upregulation of nonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900937 GO:0007219 biolink:BiologicalProcess Notch signaling pathway The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Wikipedia:Notch_signaling_pathway go.json N signaling pathway|N signalling pathway|Notch receptor signaling pathway|Notch receptor signalling pathway|Notch signalling pathway|Notch-receptor signaling pathway|Notch-receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007219 GO:0007218 biolink:BiologicalProcess neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json neuropeptide signalling pathway http://purl.obolibrary.org/obo/GO_0007218 GO:1900932 biolink:BiologicalProcess regulation of nonadec-1-ene metabolic process Any process that modulates the frequency, rate or extent of nonadec-1-ene metabolic process. go.json regulation of nonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900932 GO:0022851 biolink:MolecularActivity GABA-gated chloride ion channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0022851 GO:1900931 biolink:BiologicalProcess positive regulation of L-tyrosine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-tyrosine import into the cell. go.json activation of L-tyrosine import|activation of L-tyrosine uptake|positive regulation of L-tyrosine import|positive regulation of L-tyrosine uptake|up regulation of L-tyrosine import|up regulation of L-tyrosine uptake|up-regulation of L-tyrosine import|up-regulation of L-tyrosine uptake|upregulation of L-tyrosine import|upregulation of L-tyrosine uptake http://purl.obolibrary.org/obo/GO_1900931 GO:0007217 biolink:BiologicalProcess tachykinin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2). go.json tachykinin signalling pathway http://purl.obolibrary.org/obo/GO_0007217 GO:0022850 biolink:MolecularActivity serotonin-gated monoatomic cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. Reactome:R-HSA-9648983|Reactome:R-HSA-975311 go.json 5-hydroxytryptamine-gated receptor-channel|serotonin-activated cation-selective channel activity|serotonin-gated cation channel activity|serotonin-gated cation-selective channel activity|serotonin-gated monoatomic cation-selective channel activity http://purl.obolibrary.org/obo/GO_0022850 GO:0007216 biolink:BiologicalProcess G protein-coupled glutamate receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json G-protein coupled glutamate receptor signaling pathway|metabotropic glutamate receptor signaling pathway|metabotropic glutamate receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007216 GO:1900934 biolink:BiologicalProcess positive regulation of nonadec-1-ene metabolic process Any process that activates or increases the frequency, rate or extent of nonadec-1-ene metabolic process. go.json activation of nonadec-1-ene metabolic process|activation of nonadec-1-ene metabolism|positive regulation of nonadec-1-ene metabolism|up regulation of nonadec-1-ene metabolic process|up regulation of nonadec-1-ene metabolism|up-regulation of nonadec-1-ene metabolic process|up-regulation of nonadec-1-ene metabolism|upregulation of nonadec-1-ene metabolic process|upregulation of nonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900934 GO:0022853 biolink:MolecularActivity active monoatomic ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. go.json active ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022853 GO:1900933 biolink:BiologicalProcess negative regulation of nonadec-1-ene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process. go.json down regulation of nonadec-1-ene metabolic process|down regulation of nonadec-1-ene metabolism|down-regulation of nonadec-1-ene metabolic process|down-regulation of nonadec-1-ene metabolism|downregulation of nonadec-1-ene metabolic process|downregulation of nonadec-1-ene metabolism|inhibition of nonadec-1-ene metabolic process|inhibition of nonadec-1-ene metabolism|negative regulation of nonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900933 GO:0007215 biolink:BiologicalProcess glutamate receptor signaling pathway The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json glutamate signaling pathway|glutamate signalling pathway http://purl.obolibrary.org/obo/GO_0007215 GO:0022852 biolink:MolecularActivity glycine-gated chloride ion channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0022852 GO:0007214 biolink:BiologicalProcess gamma-aminobutyric acid signaling pathway The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell. go.json 4-aminobutanoate signaling pathway|4-aminobutanoate signalling pathway|4-aminobutyrate signaling pathway|4-aminobutyrate signalling pathway|GABA signaling pathway|GABA signalling pathway|gamma-aminobutyric acid signalling pathway http://purl.obolibrary.org/obo/GO_0007214 GO:0046866 biolink:BiologicalProcess tetraterpenoid transport The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units. go.json http://purl.obolibrary.org/obo/GO_0046866 GO:0046865 biolink:BiologicalProcess terpenoid transport The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups. go.json http://purl.obolibrary.org/obo/GO_0046865 GO:0007213 biolink:BiologicalProcess G protein-coupled acetylcholine receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. go.json G-protein coupled acetylcholine receptor signaling pathway|acetylcholine receptor signalling, muscarinic pathway|muscarinic acetylcholine receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007213 GO:1900930 biolink:BiologicalProcess negative regulation of L-tyrosine import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of L-tyrosine import into the cell. go.json down regulation of L-tyrosine import|down regulation of L-tyrosine uptake|down-regulation of L-tyrosine import|down-regulation of L-tyrosine uptake|downregulation of L-tyrosine import|downregulation of L-tyrosine uptake|inhibition of L-tyrosine import|inhibition of L-tyrosine uptake|negative regulation of L-tyrosine import|negative regulation of L-tyrosine uptake http://purl.obolibrary.org/obo/GO_1900930 GO:0046864 biolink:BiologicalProcess isoprenoid transport The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. go.json http://purl.obolibrary.org/obo/GO_0046864 goslim_pir GO:0007212 biolink:BiologicalProcess dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. go.json dopamine receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007212 GO:0007211 biolink:BiologicalProcess octopamine or tyramine signaling pathway A G protein-coupled receptor signaling pathway initiated by octopamine or tyramine binding to their receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, and ending with the regulation of a downstream cellular process. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters. go.json octopamine or tyramine signalling pathway|octopamine/tyramine signaling pathway http://purl.obolibrary.org/obo/GO_0007211 GO:0046863 biolink:MolecularActivity ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate. go.json ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity|ribulose-bisphosphate carboxylase activase activity|rubisco activase activity|rubisco activator http://purl.obolibrary.org/obo/GO_0046863 GO:0007210 biolink:BiologicalProcess serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. go.json serotonin receptor signalling pathway http://purl.obolibrary.org/obo/GO_0007210 GO:0046862 biolink:CellularComponent chromoplast membrane Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope. go.json http://purl.obolibrary.org/obo/GO_0046862 GO:0046861 biolink:CellularComponent glyoxysomal membrane The lipid bilayer surrounding a glyoxysome. go.json glyoxysome membrane http://purl.obolibrary.org/obo/GO_0046861 GO:0046860 biolink:CellularComponent glycosome membrane The lipid bilayer surrounding a glycosome. go.json http://purl.obolibrary.org/obo/GO_0046860 GO:0071829 biolink:BiologicalProcess plasma lipoprotein particle disassembly The disaggregation of a plasma lipoprotein particle into its constituent components. go.json http://purl.obolibrary.org/obo/GO_0071829 GO:0071828 biolink:BiologicalProcess apolipoprotein E recycling The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle. go.json APOE recycling http://purl.obolibrary.org/obo/GO_0071828 GO:0071827 biolink:BiologicalProcess plasma lipoprotein particle organization A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. go.json plasma lipoprotein particle organisation http://purl.obolibrary.org/obo/GO_0071827 GO:0071826 biolink:BiologicalProcess protein-RNA complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. go.json RNA-protein complex subunit organization|protein-RNA complex subunit organization|ribonucleoprotein complex subunit organisation|ribonucleoprotein complex subunit organization http://purl.obolibrary.org/obo/GO_0071826 GO:0046869 biolink:BiologicalProcess iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide. RESID:AA0331 go.json iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide http://purl.obolibrary.org/obo/GO_0046869 gocheck_do_not_annotate GO:0071825 biolink:BiologicalProcess protein-lipid complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. go.json protein-lipid complex subunit organisation|protein-lipid complex subunit organization http://purl.obolibrary.org/obo/GO_0071825 GO:0046868 biolink:CellularComponent mesosome An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins. Wikipedia:Mesosome go.json http://purl.obolibrary.org/obo/GO_0046868 GO:0071824 biolink:BiologicalProcess protein-DNA complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. go.json DNA-protein complex subunit organization|protein-DNA complex subunit organisation|protein-DNA complex subunit organization http://purl.obolibrary.org/obo/GO_0071824 GO:0046867 biolink:BiologicalProcess carotenoid transport The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. go.json http://purl.obolibrary.org/obo/GO_0046867 GO:0071823 biolink:BiologicalProcess protein-carbohydrate complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex. go.json protein-carbohydrate complex subunit organisation http://purl.obolibrary.org/obo/GO_0071823 GO:0071822 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071822 GO:0022855 biolink:MolecularActivity protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json glucose PTS transporter activity http://purl.obolibrary.org/obo/GO_0022855 GO:0022854 biolink:MolecularActivity obsolete active large uncharged polar molecule transmembrane transporter activity OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. go.json active large uncharged polar molecule transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_0022854 GO:0071821 biolink:CellularComponent FANCM-MHF complex A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes. go.json http://purl.obolibrary.org/obo/GO_0071821 GO:0022857 biolink:MolecularActivity transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. Reactome:R-HSA-1236947|Reactome:R-HSA-429036|Reactome:R-HSA-434650|Reactome:R-HSA-5638209|Reactome:R-HSA-5671707|Reactome:R-HSA-6784434|Reactome:R-HSA-6784436 go.json substrate-specific transmembrane transporter activity|substrate-specific transporter activity|uptake permease activity|uptake transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022857 goslim_chembl|goslim_drosophila|goslim_yeast GO:0071820 biolink:MolecularActivity N-box binding Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses. go.json N box binding|N-box promoter binding http://purl.obolibrary.org/obo/GO_0071820 GO:0022856 biolink:MolecularActivity protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json sorbitol PTS transporter activity http://purl.obolibrary.org/obo/GO_0022856 GO:0022859 biolink:MolecularActivity dephosphorylation-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0022859 GO:1900939 biolink:BiologicalProcess negative regulation of (Z)-nonadeca-1,14-diene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process. go.json down regulation of (Z)-nonadeca-1,14-diene metabolic process|down regulation of (Z)-nonadeca-1,14-diene metabolism|down-regulation of (Z)-nonadeca-1,14-diene metabolic process|down-regulation of (Z)-nonadeca-1,14-diene metabolism|downregulation of (Z)-nonadeca-1,14-diene metabolic process|downregulation of (Z)-nonadeca-1,14-diene metabolism|inhibition of (Z)-nonadeca-1,14-diene metabolic process|inhibition of (Z)-nonadeca-1,14-diene metabolism|negative regulation of (Z)-nonadeca-1,14-diene metabolism http://purl.obolibrary.org/obo/GO_1900939 GO:0022858 biolink:MolecularActivity alanine transmembrane transporter activity Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. go.json http://purl.obolibrary.org/obo/GO_0022858 GO:1900947 biolink:BiologicalProcess regulation of isoprene biosynthetic process Any process that modulates the frequency, rate or extent of isoprene biosynthetic process. go.json regulation of 2-methyl-1,3-butadiene biosynthesis|regulation of 2-methyl-1,3-butadiene biosynthetic process|regulation of hemiterpene biosynthesis|regulation of hemiterpene biosynthetic process http://purl.obolibrary.org/obo/GO_1900947 GO:1900946 biolink:BiologicalProcess positive regulation of isoprene metabolic process Any process that activates or increases the frequency, rate or extent of isoprene metabolic process. go.json activation of 2-methyl-1,3-butadiene metabolic process|activation of 2-methyl-1,3-butadiene metabolism|activation of hemiterpene metabolic process|activation of hemiterpene metabolism|activation of isoprene metabolic process|activation of isoprene metabolism|positive regulation of 2-methyl-1,3-butadiene metabolic process|positive regulation of 2-methyl-1,3-butadiene metabolism|positive regulation of hemiterpene metabolic process|positive regulation of hemiterpene metabolism|positive regulation of isoprene metabolism|up regulation of 2-methyl-1,3-butadiene metabolic process|up regulation of 2-methyl-1,3-butadiene metabolism|up regulation of hemiterpene metabolic process|up regulation of hemiterpene metabolism|up regulation of isoprene metabolic process|up regulation of isoprene metabolism|up-regulation of 2-methyl-1,3-butadiene metabolic process|up-regulation of 2-methyl-1,3-butadiene metabolism|up-regulation of hemiterpene metabolic process|up-regulation of hemiterpene metabolism|up-regulation of isoprene metabolic process|up-regulation of isoprene metabolism|upregulation of 2-methyl-1,3-butadiene metabolic process|upregulation of 2-methyl-1,3-butadiene metabolism|upregulation of hemiterpene metabolic process|upregulation of hemiterpene metabolism|upregulation of isoprene metabolic process|upregulation of isoprene metabolism http://purl.obolibrary.org/obo/GO_1900946 GO:1900949 biolink:BiologicalProcess positive regulation of isoprene biosynthetic process Any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process. go.json activation of 2-methyl-1,3-butadiene biosynthesis|activation of 2-methyl-1,3-butadiene biosynthetic process|activation of hemiterpene biosynthesis|activation of hemiterpene biosynthetic process|activation of isoprene biosynthetic process|positive regulation of 2-methyl-1,3-butadiene biosynthesis|positive regulation of 2-methyl-1,3-butadiene biosynthetic process|positive regulation of hemiterpene biosynthesis|positive regulation of hemiterpene biosynthetic process|up regulation of 2-methyl-1,3-butadiene biosynthesis|up regulation of 2-methyl-1,3-butadiene biosynthetic process|up regulation of hemiterpene biosynthesis|up regulation of hemiterpene biosynthetic process|up regulation of isoprene biosynthetic process|up-regulation of 2-methyl-1,3-butadiene biosynthesis|up-regulation of 2-methyl-1,3-butadiene biosynthetic process|up-regulation of hemiterpene biosynthesis|up-regulation of hemiterpene biosynthetic process|up-regulation of isoprene biosynthetic process|upregulation of 2-methyl-1,3-butadiene biosynthesis|upregulation of 2-methyl-1,3-butadiene biosynthetic process|upregulation of hemiterpene biosynthesis|upregulation of hemiterpene biosynthetic process|upregulation of isoprene biosynthetic process http://purl.obolibrary.org/obo/GO_1900949 GO:1900948 biolink:BiologicalProcess negative regulation of isoprene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process. go.json down regulation of 2-methyl-1,3-butadiene biosynthesis|down regulation of 2-methyl-1,3-butadiene biosynthetic process|down regulation of hemiterpene biosynthesis|down regulation of hemiterpene biosynthetic process|down regulation of isoprene biosynthetic process|down-regulation of 2-methyl-1,3-butadiene biosynthesis|down-regulation of 2-methyl-1,3-butadiene biosynthetic process|down-regulation of hemiterpene biosynthesis|down-regulation of hemiterpene biosynthetic process|down-regulation of isoprene biosynthetic process|downregulation of 2-methyl-1,3-butadiene biosynthesis|downregulation of 2-methyl-1,3-butadiene biosynthetic process|downregulation of hemiterpene biosynthesis|downregulation of hemiterpene biosynthetic process|downregulation of isoprene biosynthetic process|inhibition of 2-methyl-1,3-butadiene biosynthesis|inhibition of 2-methyl-1,3-butadiene biosynthetic process|inhibition of hemiterpene biosynthesis|inhibition of hemiterpene biosynthetic process|inhibition of isoprene biosynthetic process|negative regulation of 2-methyl-1,3-butadiene biosynthesis|negative regulation of 2-methyl-1,3-butadiene biosynthetic process|negative regulation of hemiterpene biosynthesis|negative regulation of hemiterpene biosynthetic process http://purl.obolibrary.org/obo/GO_1900948 GO:1900943 biolink:BiologicalProcess positive regulation of (Z)-nonadeca-1,14-diene biosynthetic process Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process. go.json activation of (Z)-nonadeca-1,14-diene anabolism|activation of (Z)-nonadeca-1,14-diene biosynthesis|activation of (Z)-nonadeca-1,14-diene biosynthetic process|activation of (Z)-nonadeca-1,14-diene formation|activation of (Z)-nonadeca-1,14-diene synthesis|positive regulation of (Z)-nonadeca-1,14-diene anabolism|positive regulation of (Z)-nonadeca-1,14-diene biosynthesis|positive regulation of (Z)-nonadeca-1,14-diene formation|positive regulation of (Z)-nonadeca-1,14-diene synthesis|up regulation of (Z)-nonadeca-1,14-diene anabolism|up regulation of (Z)-nonadeca-1,14-diene biosynthesis|up regulation of (Z)-nonadeca-1,14-diene biosynthetic process|up regulation of (Z)-nonadeca-1,14-diene formation|up regulation of (Z)-nonadeca-1,14-diene synthesis|up-regulation of (Z)-nonadeca-1,14-diene anabolism|up-regulation of (Z)-nonadeca-1,14-diene biosynthesis|up-regulation of (Z)-nonadeca-1,14-diene biosynthetic process|up-regulation of (Z)-nonadeca-1,14-diene formation|up-regulation of (Z)-nonadeca-1,14-diene synthesis|upregulation of (Z)-nonadeca-1,14-diene anabolism|upregulation of (Z)-nonadeca-1,14-diene biosynthesis|upregulation of (Z)-nonadeca-1,14-diene biosynthetic process|upregulation of (Z)-nonadeca-1,14-diene formation|upregulation of (Z)-nonadeca-1,14-diene synthesis http://purl.obolibrary.org/obo/GO_1900943 GO:0022840 biolink:MolecularActivity leak channel activity Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. go.json http://purl.obolibrary.org/obo/GO_0022840 GO:0007229 biolink:BiologicalProcess integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json integrin-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0007229 GO:1900942 biolink:BiologicalProcess negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process. go.json down regulation of (Z)-nonadeca-1,14-diene anabolism|down regulation of (Z)-nonadeca-1,14-diene biosynthesis|down regulation of (Z)-nonadeca-1,14-diene biosynthetic process|down regulation of (Z)-nonadeca-1,14-diene formation|down regulation of (Z)-nonadeca-1,14-diene synthesis|down-regulation of (Z)-nonadeca-1,14-diene anabolism|down-regulation of (Z)-nonadeca-1,14-diene biosynthesis|down-regulation of (Z)-nonadeca-1,14-diene biosynthetic process|down-regulation of (Z)-nonadeca-1,14-diene formation|down-regulation of (Z)-nonadeca-1,14-diene synthesis|downregulation of (Z)-nonadeca-1,14-diene anabolism|downregulation of (Z)-nonadeca-1,14-diene biosynthesis|downregulation of (Z)-nonadeca-1,14-diene biosynthetic process|downregulation of (Z)-nonadeca-1,14-diene formation|downregulation of (Z)-nonadeca-1,14-diene synthesis|inhibition of (Z)-nonadeca-1,14-diene anabolism|inhibition of (Z)-nonadeca-1,14-diene biosynthesis|inhibition of (Z)-nonadeca-1,14-diene biosynthetic process|inhibition of (Z)-nonadeca-1,14-diene formation|inhibition of (Z)-nonadeca-1,14-diene synthesis|negative regulation of (Z)-nonadeca-1,14-diene anabolism|negative regulation of (Z)-nonadeca-1,14-diene biosynthesis|negative regulation of (Z)-nonadeca-1,14-diene formation|negative regulation of (Z)-nonadeca-1,14-diene synthesis http://purl.obolibrary.org/obo/GO_1900942 GO:0007228 biolink:BiologicalProcess positive regulation of hh target transcription factor activity Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited. go.json activation of hh target transcription factor|positive regulation of hedgehog target transcription factor http://purl.obolibrary.org/obo/GO_0007228 gocheck_do_not_annotate GO:1900945 biolink:BiologicalProcess negative regulation of isoprene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process. go.json down regulation of 2-methyl-1,3-butadiene metabolic process|down regulation of 2-methyl-1,3-butadiene metabolism|down regulation of hemiterpene metabolic process|down regulation of hemiterpene metabolism|down regulation of isoprene metabolic process|down regulation of isoprene metabolism|down-regulation of 2-methyl-1,3-butadiene metabolic process|down-regulation of 2-methyl-1,3-butadiene metabolism|down-regulation of hemiterpene metabolic process|down-regulation of hemiterpene metabolism|down-regulation of isoprene metabolic process|down-regulation of isoprene metabolism|downregulation of 2-methyl-1,3-butadiene metabolic process|downregulation of 2-methyl-1,3-butadiene metabolism|downregulation of hemiterpene metabolic process|downregulation of hemiterpene metabolism|downregulation of isoprene metabolic process|downregulation of isoprene metabolism|inhibition of 2-methyl-1,3-butadiene metabolic process|inhibition of 2-methyl-1,3-butadiene metabolism|inhibition of hemiterpene metabolic process|inhibition of hemiterpene metabolism|inhibition of isoprene metabolic process|inhibition of isoprene metabolism|negative regulation of 2-methyl-1,3-butadiene metabolic process|negative regulation of 2-methyl-1,3-butadiene metabolism|negative regulation of hemiterpene metabolic process|negative regulation of hemiterpene metabolism|negative regulation of isoprene metabolism http://purl.obolibrary.org/obo/GO_1900945 GO:0007227 biolink:BiologicalProcess signal transduction downstream of smoothened The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. go.json http://purl.obolibrary.org/obo/GO_0007227 GO:0022842 biolink:MolecularActivity narrow pore channel activity Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. go.json http://purl.obolibrary.org/obo/GO_0022842 GO:0022841 biolink:MolecularActivity potassium ion leak channel activity Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. go.json http://purl.obolibrary.org/obo/GO_0022841 GO:1900944 biolink:BiologicalProcess regulation of isoprene metabolic process Any process that modulates the frequency, rate or extent of isoprene metabolic process. go.json regulation of 2-methyl-1,3-butadiene metabolic process|regulation of 2-methyl-1,3-butadiene metabolism|regulation of hemiterpene metabolic process|regulation of hemiterpene metabolism|regulation of isoprene metabolism http://purl.obolibrary.org/obo/GO_1900944 GO:0007226 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007226 GO:0046877 biolink:BiologicalProcess regulation of saliva secretion Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0046877 GO:0007225 biolink:BiologicalProcess patched ligand maturation The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups. go.json Hedgehog protein processing|hh protein processing|patched ligand processing http://purl.obolibrary.org/obo/GO_0007225 GO:0046876 biolink:MolecularActivity 3,4-didehydroretinal binding Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod). go.json UV-sensitive opsin|blue-sensitive opsin|green-sensitive opsin|long-wave-sensitive opsin|opsin|red-sensitive opsin|short-wave-sensitive opsin|violet-sensitive opsin http://purl.obolibrary.org/obo/GO_0046876 GO:0007224 biolink:BiologicalProcess smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. Wikipedia:Hedgehog_signaling_pathway go.json Shh signaling pathway|Sonic hedgehog signaling pathway|hedgehog signaling pathway|hh signaling pathway|hh signalling pathway|smoothened signalling pathway http://purl.obolibrary.org/obo/GO_0007224 GO:1900941 biolink:BiologicalProcess regulation of (Z)-nonadeca-1,14-diene biosynthetic process Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process. go.json regulation of (Z)-nonadeca-1,14-diene anabolism|regulation of (Z)-nonadeca-1,14-diene biosynthesis|regulation of (Z)-nonadeca-1,14-diene formation|regulation of (Z)-nonadeca-1,14-diene synthesis http://purl.obolibrary.org/obo/GO_1900941 GO:0007223 biolink:BiologicalProcess Wnt signaling pathway, calcium modulating pathway The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). go.json Wnt receptor signaling pathway, calcium modulating pathway|Wnt-activated signaling pathway, calcium modulating pathway|frizzled-2 signaling pathway|frizzled-2 signalling pathway|non-canonical Wnt signaling pathway http://purl.obolibrary.org/obo/GO_0007223 GO:0046875 biolink:MolecularActivity ephrin receptor binding Binding to an ephrin receptor. go.json Eph receptor binding|GPI-linked ephrin|ephrin|transmembrane ephrin http://purl.obolibrary.org/obo/GO_0046875 GO:1900940 biolink:BiologicalProcess positive regulation of (Z)-nonadeca-1,14-diene metabolic process Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process. go.json activation of (Z)-nonadeca-1,14-diene metabolic process|activation of (Z)-nonadeca-1,14-diene metabolism|positive regulation of (Z)-nonadeca-1,14-diene metabolism|up regulation of (Z)-nonadeca-1,14-diene metabolic process|up regulation of (Z)-nonadeca-1,14-diene metabolism|up-regulation of (Z)-nonadeca-1,14-diene metabolic process|up-regulation of (Z)-nonadeca-1,14-diene metabolism|upregulation of (Z)-nonadeca-1,14-diene metabolic process|upregulation of (Z)-nonadeca-1,14-diene metabolism http://purl.obolibrary.org/obo/GO_1900940 GO:0046874 biolink:BiologicalProcess quinolinate metabolic process The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. go.json quinolinate metabolism http://purl.obolibrary.org/obo/GO_0046874 GO:0007222 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007222 GO:0007221 biolink:BiologicalProcess positive regulation of transcription of Notch receptor target The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. go.json N receptor target transcription factor activation|Notch receptor target transcription factor activation http://purl.obolibrary.org/obo/GO_0007221 GO:0046873 biolink:MolecularActivity metal ion transmembrane transporter activity Enables the transfer of metal ions from one side of a membrane to the other. go.json heavy metal ion porter activity|heavy metal ion transporter activity|heavy metal ion:hydrogen symporter activity|heavy metal-exporting ATPase activity|high affinity metal ion uptake transporter activity|low affinity metal ion uptake transporter activity http://purl.obolibrary.org/obo/GO_0046873 GO:0007220 biolink:BiologicalProcess Notch receptor processing The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. go.json N receptor processing http://purl.obolibrary.org/obo/GO_0007220 GO:0046872 biolink:MolecularActivity metal ion binding Binding to a metal ion. go.json heavy metal binding|metal binding http://purl.obolibrary.org/obo/GO_0046872 goslim_agr|goslim_drosophila|goslim_flybase_ribbon|goslim_metagenomics GO:0046871 biolink:MolecularActivity N-acetylgalactosamine binding Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine. go.json N-acetylgalactosamine lectin http://purl.obolibrary.org/obo/GO_0046871 GO:0071809 biolink:BiologicalProcess regulation of fever generation by regulation of prostaglandin biosynthesis Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. go.json http://purl.obolibrary.org/obo/GO_0071809 GO:0046870 biolink:MolecularActivity cadmium ion binding Binding to a cadmium ion (Cd). go.json Cd ion binding|cadmium binding|copper/cadmium binding http://purl.obolibrary.org/obo/GO_0046870 GO:0071819 biolink:CellularComponent DUBm complex A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p. go.json SAGA DUBm complex|deubiquitinating module|deubiquitination module http://purl.obolibrary.org/obo/GO_0071819 GO:0071818 biolink:CellularComponent BAT3 complex A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A. go.json BAG6-UBL4A-TRC35 complex|BAT3-TRC35-UBL4A complex|Bag6 complex http://purl.obolibrary.org/obo/GO_0071818 GO:0071817 biolink:CellularComponent MMXD complex A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation. go.json MMS19-MIP18-XPD complex http://purl.obolibrary.org/obo/GO_0071817 GO:0071816 biolink:BiologicalProcess tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region. go.json protein insertion of tail-anchored membrane proteins into ER membrane|tail-anchored membrane protein insertion into endoplasmic reticulum membrane|type II transmembrane protein insertion into ER membrane http://purl.obolibrary.org/obo/GO_0071816 GO:0071815 biolink:MolecularActivity intermediate-density lipoprotein particle binding Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. go.json IDL binding|intermediate-density lipoprotein binding http://purl.obolibrary.org/obo/GO_0071815 GO:0071814 biolink:MolecularActivity protein-lipid complex binding Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. go.json http://purl.obolibrary.org/obo/GO_0071814 GO:0071813 biolink:MolecularActivity lipoprotein particle binding Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. go.json lipoprotein binding|plasma lipoprotein binding|plasma lipoprotein particle binding http://purl.obolibrary.org/obo/GO_0071813 GO:0046879 biolink:BiologicalProcess hormone secretion The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. go.json http://purl.obolibrary.org/obo/GO_0046879 GO:0046878 biolink:BiologicalProcess positive regulation of saliva secretion Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. go.json activation of saliva secretion|stimulation of saliva secretion|up regulation of saliva secretion|up-regulation of saliva secretion|upregulation of saliva secretion http://purl.obolibrary.org/obo/GO_0046878 GO:0071812 biolink:BiologicalProcess positive regulation of fever generation by positive regulation of prostaglandin secretion Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell. go.json http://purl.obolibrary.org/obo/GO_0071812 GO:0071811 biolink:BiologicalProcess positive regulation of fever generation by positive regulation of prostaglandin biosynthesis Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. go.json http://purl.obolibrary.org/obo/GO_0071811 GO:0022844 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022844 GO:0022843 biolink:MolecularActivity voltage-gated monoatomic cation channel activity Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. Reactome:R-HSA-2534378|Reactome:R-HSA-6788999 go.json voltage-gated cation channel activity http://purl.obolibrary.org/obo/GO_0022843 GO:0071810 biolink:BiologicalProcess regulation of fever generation by regulation of prostaglandin secretion Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell. go.json http://purl.obolibrary.org/obo/GO_0071810 GO:0022848 biolink:MolecularActivity acetylcholine-gated monoatomic cation-selective channel activity Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. go.json acetylcholine-activated cation-selective channel activity|acetylcholine-gated cation channel activity|acetylcholine-gated cation-selective channel activity|ionotropic acetylcholine receptor activity|nAChR|nicotinergic acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity http://purl.obolibrary.org/obo/GO_0022848 GO:0022849 biolink:MolecularActivity glutamate-gated calcium ion channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0022849 GO:1900958 biolink:BiologicalProcess positive regulation of 17-methylnonadec-1-ene biosynthetic process Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. go.json activation of 17-methylnonadec-1-ene anabolism|activation of 17-methylnonadec-1-ene biosynthesis|activation of 17-methylnonadec-1-ene biosynthetic process|activation of 17-methylnonadec-1-ene formation|activation of 17-methylnonadec-1-ene synthesis|positive regulation of 17-methylnonadec-1-ene anabolism|positive regulation of 17-methylnonadec-1-ene biosynthesis|positive regulation of 17-methylnonadec-1-ene formation|positive regulation of 17-methylnonadec-1-ene synthesis|up regulation of 17-methylnonadec-1-ene anabolism|up regulation of 17-methylnonadec-1-ene biosynthesis|up regulation of 17-methylnonadec-1-ene biosynthetic process|up regulation of 17-methylnonadec-1-ene formation|up regulation of 17-methylnonadec-1-ene synthesis|up-regulation of 17-methylnonadec-1-ene anabolism|up-regulation of 17-methylnonadec-1-ene biosynthesis|up-regulation of 17-methylnonadec-1-ene biosynthetic process|up-regulation of 17-methylnonadec-1-ene formation|up-regulation of 17-methylnonadec-1-ene synthesis|upregulation of 17-methylnonadec-1-ene anabolism|upregulation of 17-methylnonadec-1-ene biosynthesis|upregulation of 17-methylnonadec-1-ene biosynthetic process|upregulation of 17-methylnonadec-1-ene formation|upregulation of 17-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900958 GO:0046880 biolink:BiologicalProcess regulation of follicle-stimulating hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone. go.json regulation of FSH secretion|regulation of follicle stimulating hormone secretion http://purl.obolibrary.org/obo/GO_0046880 GO:1900957 biolink:BiologicalProcess negative regulation of 17-methylnonadec-1-ene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. go.json down regulation of 17-methylnonadec-1-ene anabolism|down regulation of 17-methylnonadec-1-ene biosynthesis|down regulation of 17-methylnonadec-1-ene biosynthetic process|down regulation of 17-methylnonadec-1-ene formation|down regulation of 17-methylnonadec-1-ene synthesis|down-regulation of 17-methylnonadec-1-ene anabolism|down-regulation of 17-methylnonadec-1-ene biosynthesis|down-regulation of 17-methylnonadec-1-ene biosynthetic process|down-regulation of 17-methylnonadec-1-ene formation|down-regulation of 17-methylnonadec-1-ene synthesis|downregulation of 17-methylnonadec-1-ene anabolism|downregulation of 17-methylnonadec-1-ene biosynthesis|downregulation of 17-methylnonadec-1-ene biosynthetic process|downregulation of 17-methylnonadec-1-ene formation|downregulation of 17-methylnonadec-1-ene synthesis|inhibition of 17-methylnonadec-1-ene anabolism|inhibition of 17-methylnonadec-1-ene biosynthesis|inhibition of 17-methylnonadec-1-ene biosynthetic process|inhibition of 17-methylnonadec-1-ene formation|inhibition of 17-methylnonadec-1-ene synthesis|negative regulation of 17-methylnonadec-1-ene anabolism|negative regulation of 17-methylnonadec-1-ene biosynthesis|negative regulation of 17-methylnonadec-1-ene formation|negative regulation of 17-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900957 GO:1900959 biolink:BiologicalProcess regulation of 17-methylnonadec-1-ene metabolic process Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process. go.json regulation of 17-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900959 GO:1900954 biolink:BiologicalProcess negative regulation of 18-methylnonadec-1-ene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process. go.json down regulation of 18-methylnonadec-1-ene metabolic process|down regulation of 18-methylnonadec-1-ene metabolism|down-regulation of 18-methylnonadec-1-ene metabolic process|down-regulation of 18-methylnonadec-1-ene metabolism|downregulation of 18-methylnonadec-1-ene metabolic process|downregulation of 18-methylnonadec-1-ene metabolism|inhibition of 18-methylnonadec-1-ene metabolic process|inhibition of 18-methylnonadec-1-ene metabolism|negative regulation of 18-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900954 GO:1900953 biolink:BiologicalProcess regulation of 18-methylnonadec-1-ene metabolic process Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process. go.json regulation of 18-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900953 GO:1900956 biolink:BiologicalProcess regulation of 17-methylnonadec-1-ene biosynthetic process Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. go.json regulation of 17-methylnonadec-1-ene anabolism|regulation of 17-methylnonadec-1-ene biosynthesis|regulation of 17-methylnonadec-1-ene formation|regulation of 17-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900956 GO:0022831 biolink:MolecularActivity narrow pore, gated channel activity Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus. Wikipedia:Ion_channels go.json ion channels http://purl.obolibrary.org/obo/GO_0022831 GO:1900955 biolink:BiologicalProcess positive regulation of 18-methylnonadec-1-ene metabolic process Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process. go.json activation of 18-methylnonadec-1-ene metabolic process|activation of 18-methylnonadec-1-ene metabolism|positive regulation of 18-methylnonadec-1-ene metabolism|up regulation of 18-methylnonadec-1-ene metabolic process|up regulation of 18-methylnonadec-1-ene metabolism|up-regulation of 18-methylnonadec-1-ene metabolic process|up-regulation of 18-methylnonadec-1-ene metabolism|upregulation of 18-methylnonadec-1-ene metabolic process|upregulation of 18-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900955 GO:0046888 biolink:BiologicalProcess negative regulation of hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. go.json down regulation of hormone secretion|down-regulation of hormone secretion|downregulation of hormone secretion|inhibition of hormone secretion http://purl.obolibrary.org/obo/GO_0046888 GO:1900950 biolink:BiologicalProcess regulation of 18-methylnonadec-1-ene biosynthetic process Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. go.json regulation of 18-methylnonadec-1-ene anabolism|regulation of 18-methylnonadec-1-ene biosynthesis|regulation of 18-methylnonadec-1-ene formation|regulation of 18-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900950 GO:0046887 biolink:BiologicalProcess positive regulation of hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. go.json activation of hormone secretion|stimulation of hormone secretion|up regulation of hormone secretion|up-regulation of hormone secretion|upregulation of hormone secretion http://purl.obolibrary.org/obo/GO_0046887 GO:1900952 biolink:BiologicalProcess positive regulation of 18-methylnonadec-1-ene biosynthetic process Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. go.json activation of 18-methylnonadec-1-ene anabolism|activation of 18-methylnonadec-1-ene biosynthesis|activation of 18-methylnonadec-1-ene biosynthetic process|activation of 18-methylnonadec-1-ene formation|activation of 18-methylnonadec-1-ene synthesis|positive regulation of 18-methylnonadec-1-ene anabolism|positive regulation of 18-methylnonadec-1-ene biosynthesis|positive regulation of 18-methylnonadec-1-ene formation|positive regulation of 18-methylnonadec-1-ene synthesis|up regulation of 18-methylnonadec-1-ene anabolism|up regulation of 18-methylnonadec-1-ene biosynthesis|up regulation of 18-methylnonadec-1-ene biosynthetic process|up regulation of 18-methylnonadec-1-ene formation|up regulation of 18-methylnonadec-1-ene synthesis|up-regulation of 18-methylnonadec-1-ene anabolism|up-regulation of 18-methylnonadec-1-ene biosynthesis|up-regulation of 18-methylnonadec-1-ene biosynthetic process|up-regulation of 18-methylnonadec-1-ene formation|up-regulation of 18-methylnonadec-1-ene synthesis|upregulation of 18-methylnonadec-1-ene anabolism|upregulation of 18-methylnonadec-1-ene biosynthesis|upregulation of 18-methylnonadec-1-ene biosynthetic process|upregulation of 18-methylnonadec-1-ene formation|upregulation of 18-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900952 GO:0046886 biolink:BiologicalProcess positive regulation of hormone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. go.json activation of hormone biosynthetic process|positive regulation of hormone anabolism|positive regulation of hormone biosynthesis|positive regulation of hormone formation|positive regulation of hormone synthesis|stimulation of hormone biosynthetic process|up regulation of hormone biosynthetic process|up-regulation of hormone biosynthetic process|upregulation of hormone biosynthetic process http://purl.obolibrary.org/obo/GO_0046886 GO:1900951 biolink:BiologicalProcess negative regulation of 18-methylnonadec-1-ene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. go.json down regulation of 18-methylnonadec-1-ene anabolism|down regulation of 18-methylnonadec-1-ene biosynthesis|down regulation of 18-methylnonadec-1-ene biosynthetic process|down regulation of 18-methylnonadec-1-ene formation|down regulation of 18-methylnonadec-1-ene synthesis|down-regulation of 18-methylnonadec-1-ene anabolism|down-regulation of 18-methylnonadec-1-ene biosynthesis|down-regulation of 18-methylnonadec-1-ene biosynthetic process|down-regulation of 18-methylnonadec-1-ene formation|down-regulation of 18-methylnonadec-1-ene synthesis|downregulation of 18-methylnonadec-1-ene anabolism|downregulation of 18-methylnonadec-1-ene biosynthesis|downregulation of 18-methylnonadec-1-ene biosynthetic process|downregulation of 18-methylnonadec-1-ene formation|downregulation of 18-methylnonadec-1-ene synthesis|inhibition of 18-methylnonadec-1-ene anabolism|inhibition of 18-methylnonadec-1-ene biosynthesis|inhibition of 18-methylnonadec-1-ene biosynthetic process|inhibition of 18-methylnonadec-1-ene formation|inhibition of 18-methylnonadec-1-ene synthesis|negative regulation of 18-methylnonadec-1-ene anabolism|negative regulation of 18-methylnonadec-1-ene biosynthesis|negative regulation of 18-methylnonadec-1-ene formation|negative regulation of 18-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900951 GO:0046885 biolink:BiologicalProcess regulation of hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. go.json regulation of hormone anabolism|regulation of hormone biosynthesis|regulation of hormone formation|regulation of hormone synthesis http://purl.obolibrary.org/obo/GO_0046885 GO:0046884 biolink:BiologicalProcess follicle-stimulating hormone secretion The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. go.json FSH secretion|follicle stimulating hormone secretion|follitropin secretion http://purl.obolibrary.org/obo/GO_0046884 GO:0046883 biolink:BiologicalProcess regulation of hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. go.json http://purl.obolibrary.org/obo/GO_0046883 GO:0046882 biolink:BiologicalProcess negative regulation of follicle-stimulating hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone. go.json down regulation of follicle-stimulating hormone secretion|down-regulation of follicle-stimulating hormone secretion|downregulation of follicle-stimulating hormone secretion|inhibition of follicle-stimulating hormone secretion|negative regulation of follicle stimulating hormone secretion http://purl.obolibrary.org/obo/GO_0046882 GO:0046881 biolink:BiologicalProcess positive regulation of follicle-stimulating hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone. go.json activation of follicle-stimulating hormone secretion|positive regulation of follicle stimulating hormone secretion|stimulation of follicle-stimulating hormone secretion|up regulation of follicle-stimulating hormone secretion|up-regulation of follicle-stimulating hormone secretion|upregulation of follicle-stimulating hormone secretion http://purl.obolibrary.org/obo/GO_0046881 GO:0071849 biolink:BiologicalProcess obsolete G1 cell cycle arrest in response to nitrogen starvation OBSOLETE. The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen. go.json True http://purl.obolibrary.org/obo/GO_0071849 GO:0071848 biolink:BiologicalProcess positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade. go.json positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling http://purl.obolibrary.org/obo/GO_0071848 GO:0071847 biolink:BiologicalProcess TNFSF11-mediated signaling pathway The series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json RANKL-mediated signaling pathway|TNF-related activation-induced cytokine-mediated signaling pathway|TNFSF11-mediated signalling pathway|receptor activator of nuclear factor kappa-B ligand signaling pathway|tumor necrosis factor superfamily member 11-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0071847 GO:0071846 biolink:BiologicalProcess actin filament debranching An actin filament severing process that results in the removal of actin filament branches specifically at the branch points. go.json http://purl.obolibrary.org/obo/GO_0071846 GO:0046889 biolink:BiologicalProcess positive regulation of lipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. go.json activation of lipid biosynthetic process|positive regulation of lipid anabolism|positive regulation of lipid biosynthesis|positive regulation of lipid formation|positive regulation of lipid synthesis|positive regulation of lipogenesis|stimulation of lipid biosynthetic process|up regulation of lipid biosynthetic process|up-regulation of lipid biosynthetic process|upregulation of lipid biosynthetic process http://purl.obolibrary.org/obo/GO_0046889 GO:0071845 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071845 GO:0071844 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071844 GO:0022833 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022833 GO:0071843 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071843 GO:0022832 biolink:MolecularActivity voltage-gated channel activity Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. go.json http://purl.obolibrary.org/obo/GO_0022832 GO:0022835 biolink:MolecularActivity transmitter-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. go.json extracellular substance gated channel activity|neurotransmitter-gated channel activity http://purl.obolibrary.org/obo/GO_0022835 GO:0071842 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071842 GO:0022834 biolink:MolecularActivity ligand-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0022834 GO:0071841 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071841 GO:0071840 biolink:BiologicalProcess cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. go.json cellular component organisation or biogenesis|cellular component organisation or biogenesis at cellular level|cellular component organization or biogenesis at cellular level http://purl.obolibrary.org/obo/GO_0071840 goslim_flybase_ribbon|goslim_metagenomics GO:0022836 biolink:MolecularActivity gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. go.json http://purl.obolibrary.org/obo/GO_0022836 GO:0022839 biolink:MolecularActivity monoatomic ion-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. go.json ion gated channel activity|monoatomic ion gated channel activity http://purl.obolibrary.org/obo/GO_0022839 GO:0022838 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022838 GO:1900969 biolink:BiologicalProcess negative regulation of sarcinapterin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process. go.json down regulation of sarcinapterin metabolic process|down regulation of sarcinapterin metabolism|down-regulation of sarcinapterin metabolic process|down-regulation of sarcinapterin metabolism|downregulation of sarcinapterin metabolic process|downregulation of sarcinapterin metabolism|inhibition of sarcinapterin metabolic process|inhibition of sarcinapterin metabolism|negative regulation of sarcinapterin metabolism http://purl.obolibrary.org/obo/GO_1900969 GO:0046891 biolink:BiologicalProcess peptidyl-cysteine S-carbamoylation The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine. RESID:AA0332 go.json http://purl.obolibrary.org/obo/GO_0046891 gocheck_do_not_annotate GO:1900968 biolink:BiologicalProcess regulation of sarcinapterin metabolic process Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process. go.json regulation of sarcinapterin metabolism http://purl.obolibrary.org/obo/GO_1900968 GO:0046890 biolink:BiologicalProcess regulation of lipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. go.json regulation of lipid anabolism|regulation of lipid biosynthesis|regulation of lipid formation|regulation of lipid synthesis|regulation of lipogenesis http://purl.obolibrary.org/obo/GO_0046890 GO:0007209 biolink:BiologicalProcess phospholipase C-activating tachykinin receptor signaling pathway A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activation of phospholipase C activity by tachykinin receptor signaling pathway|activation of phospholipase C activity by tachykinin receptor signalling pathway|tachykinin receptor, phospholipase C activating pathway http://purl.obolibrary.org/obo/GO_0007209 GO:0007208 biolink:BiologicalProcess phospholipase C-activating serotonin receptor signaling pathway A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activation of phospholipase C activity by serotonin receptor signaling pathway|activation of phospholipase C activity by serotonin receptor signalling pathway|serotonin receptor, phospholipase C activating pathway http://purl.obolibrary.org/obo/GO_0007208 GO:0007207 biolink:BiologicalProcess phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway|muscarinic acetylcholine receptor, phospholipase C activating pathway|muscarinic receptor signaling pathway via activation of PLC|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007207 GO:1900965 biolink:BiologicalProcess regulation of methanophenazine metabolic process Any process that modulates the frequency, rate or extent of methanophenazine metabolic process. go.json regulation of methanophenazine metabolism http://purl.obolibrary.org/obo/GO_1900965 GO:1900964 biolink:BiologicalProcess positive regulation of methanophenazine biosynthetic process Any process that activates or increases the frequency, rate or extent of methanophenazine biosynthetic process. go.json activation of methanophenazine anabolism|activation of methanophenazine biosynthesis|activation of methanophenazine biosynthetic process|activation of methanophenazine formation|activation of methanophenazine synthesis|positive regulation of methanophenazine anabolism|positive regulation of methanophenazine biosynthesis|positive regulation of methanophenazine formation|positive regulation of methanophenazine synthesis|up regulation of methanophenazine anabolism|up regulation of methanophenazine biosynthesis|up regulation of methanophenazine biosynthetic process|up regulation of methanophenazine formation|up regulation of methanophenazine synthesis|up-regulation of methanophenazine anabolism|up-regulation of methanophenazine biosynthesis|up-regulation of methanophenazine biosynthetic process|up-regulation of methanophenazine formation|up-regulation of methanophenazine synthesis|upregulation of methanophenazine anabolism|upregulation of methanophenazine biosynthesis|upregulation of methanophenazine biosynthetic process|upregulation of methanophenazine formation|upregulation of methanophenazine synthesis http://purl.obolibrary.org/obo/GO_1900964 GO:0007206 biolink:BiologicalProcess phospholipase C-activating G protein-coupled glutamate receptor signaling pathway A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway|activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway|metabotropic glutamate receptor, phospholipase C activating pathway|phospholipase C-activating G-protein coupled glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007206 GO:1900967 biolink:BiologicalProcess positive regulation of methanophenazine metabolic process Any process that activates or increases the frequency, rate or extent of methanophenazine metabolic process. go.json activation of methanophenazine metabolic process|activation of methanophenazine metabolism|positive regulation of methanophenazine metabolism|up regulation of methanophenazine metabolic process|up regulation of methanophenazine metabolism|up-regulation of methanophenazine metabolic process|up-regulation of methanophenazine metabolism|upregulation of methanophenazine metabolic process|upregulation of methanophenazine metabolism http://purl.obolibrary.org/obo/GO_1900967 GO:0007205 biolink:BiologicalProcess protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). go.json activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007205 GO:0022820 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022820 GO:0007204 biolink:BiologicalProcess positive regulation of cytosolic calcium ion concentration Any process that increases the concentration of calcium ions in the cytosol. go.json cytoplasmic calcium ion concentration elevation|cytosolic calcium ion concentration elevation|elevation of calcium ion concentration in cytoplasm|elevation of calcium ion concentration in cytosol|elevation of cytoplasmic calcium ion concentration|elevation of cytosolic calcium ion concentration http://purl.obolibrary.org/obo/GO_0007204 GO:1900966 biolink:BiologicalProcess negative regulation of methanophenazine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine metabolic process. go.json down regulation of methanophenazine metabolic process|down regulation of methanophenazine metabolism|down-regulation of methanophenazine metabolic process|down-regulation of methanophenazine metabolism|downregulation of methanophenazine metabolic process|downregulation of methanophenazine metabolism|inhibition of methanophenazine metabolic process|inhibition of methanophenazine metabolism|negative regulation of methanophenazine metabolism http://purl.obolibrary.org/obo/GO_1900966 GO:0046899 biolink:MolecularActivity nucleoside triphosphate adenylate kinase activity Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. EC:2.7.4.10|MetaCyc:2.7.4.10-RXN|RHEA:13749|Reactome:R-HSA-1008248 go.json GTP:AMP phosphotransferase|guanosine triphosphate-adenylate kinase|isozyme 3 of adenylate kinase activity|nucleoside triphosphate-adenosine monophosphate transphosphorylase activity|nucleoside-triphosphate-adenylate kinase activity|nucleoside-triphosphate:AMP phosphotransferase activity http://purl.obolibrary.org/obo/GO_0046899 GO:1900961 biolink:BiologicalProcess positive regulation of 17-methylnonadec-1-ene metabolic process Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process. go.json activation of 17-methylnonadec-1-ene metabolic process|activation of 17-methylnonadec-1-ene metabolism|positive regulation of 17-methylnonadec-1-ene metabolism|up regulation of 17-methylnonadec-1-ene metabolic process|up regulation of 17-methylnonadec-1-ene metabolism|up-regulation of 17-methylnonadec-1-ene metabolic process|up-regulation of 17-methylnonadec-1-ene metabolism|upregulation of 17-methylnonadec-1-ene metabolic process|upregulation of 17-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900961 GO:0007203 biolink:BiologicalProcess obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis OBSOLETE. (Was not defined before being made obsolete). go.json phosphatidylinositol-4,5-bisphosphate hydrolysis True http://purl.obolibrary.org/obo/GO_0007203 GO:1900960 biolink:BiologicalProcess negative regulation of 17-methylnonadec-1-ene metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process. go.json down regulation of 17-methylnonadec-1-ene metabolic process|down regulation of 17-methylnonadec-1-ene metabolism|down-regulation of 17-methylnonadec-1-ene metabolic process|down-regulation of 17-methylnonadec-1-ene metabolism|downregulation of 17-methylnonadec-1-ene metabolic process|downregulation of 17-methylnonadec-1-ene metabolism|inhibition of 17-methylnonadec-1-ene metabolic process|inhibition of 17-methylnonadec-1-ene metabolism|negative regulation of 17-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900960 GO:0007202 biolink:BiologicalProcess activation of phospholipase C activity The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. go.json phospholipase C activation http://purl.obolibrary.org/obo/GO_0007202 gocheck_do_not_annotate GO:0046898 biolink:BiologicalProcess response to cycloheximide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. go.json response to actidione http://purl.obolibrary.org/obo/GO_0046898 GO:0046897 biolink:BiologicalProcess N-terminal peptidyl-tyrosine methylation The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine. RESID:AA0338 go.json http://purl.obolibrary.org/obo/GO_0046897 gocheck_do_not_annotate GO:1900963 biolink:BiologicalProcess negative regulation of methanophenazine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine biosynthetic process. go.json down regulation of methanophenazine anabolism|down regulation of methanophenazine biosynthesis|down regulation of methanophenazine biosynthetic process|down regulation of methanophenazine formation|down regulation of methanophenazine synthesis|down-regulation of methanophenazine anabolism|down-regulation of methanophenazine biosynthesis|down-regulation of methanophenazine biosynthetic process|down-regulation of methanophenazine formation|down-regulation of methanophenazine synthesis|downregulation of methanophenazine anabolism|downregulation of methanophenazine biosynthesis|downregulation of methanophenazine biosynthetic process|downregulation of methanophenazine formation|downregulation of methanophenazine synthesis|inhibition of methanophenazine anabolism|inhibition of methanophenazine biosynthesis|inhibition of methanophenazine biosynthetic process|inhibition of methanophenazine formation|inhibition of methanophenazine synthesis|negative regulation of methanophenazine anabolism|negative regulation of methanophenazine biosynthesis|negative regulation of methanophenazine formation|negative regulation of methanophenazine synthesis http://purl.obolibrary.org/obo/GO_1900963 GO:0007201 biolink:BiologicalProcess obsolete G-protein dissociation OBSOLETE. (Was not defined before being made obsolete). go.json G-protein dissociation True http://purl.obolibrary.org/obo/GO_0007201 GO:0046896 biolink:BiologicalProcess N-terminal peptidyl-leucine methylation The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine. RESID:AA0337 go.json http://purl.obolibrary.org/obo/GO_0046896 gocheck_do_not_annotate GO:1900962 biolink:BiologicalProcess regulation of methanophenazine biosynthetic process Any process that modulates the frequency, rate or extent of methanophenazine biosynthetic process. go.json regulation of methanophenazine anabolism|regulation of methanophenazine biosynthesis|regulation of methanophenazine formation|regulation of methanophenazine synthesis http://purl.obolibrary.org/obo/GO_1900962 GO:0007200 biolink:BiologicalProcess phospholipase C-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). go.json G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|G protein signalling, coupled to IP3 second messenger (phospholipase C activating)|G-protein coupled receptor signaling pathway coupled to IP3 second messenger|G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|PLC-activating GPCR signaling pathway|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|phospholipase C-activating G-protein coupled receptor signaling pathway|phospholipase C-activating dopamine receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007200 GO:0046895 biolink:BiologicalProcess N-terminal peptidyl-isoleucine methylation The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine. RESID:AA0336 go.json http://purl.obolibrary.org/obo/GO_0046895 gocheck_do_not_annotate GO:0046894 biolink:BiologicalProcess obsolete enzyme active site formation via S-amidino-L-cysteine OBSOLETE. Active site formation via the transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine. go.json True http://purl.obolibrary.org/obo/GO_0046894 GO:0046893 biolink:BiologicalProcess iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase. RESID:AA0334 go.json http://purl.obolibrary.org/obo/GO_0046893 gocheck_do_not_annotate GO:0046892 biolink:BiologicalProcess peptidyl-S-carbamoyl-L-cysteine dehydration The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine. RESID:AA0333 go.json formation of peptidyl-S-cyanocysteine|formation of peptidyl-serine thiocyanate ester http://purl.obolibrary.org/obo/GO_0046892 gocheck_do_not_annotate GO:0140096 biolink:MolecularActivity catalytic activity, acting on a protein Catalytic activity that acts to modify a protein. go.json http://purl.obolibrary.org/obo/GO_0140096 goslim_generic|prokaryote_subset GO:0022829 biolink:MolecularActivity wide pore channel activity Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. go.json gap junction activity|non-gated, wide pore channel activity http://purl.obolibrary.org/obo/GO_0022829 GO:0071839 biolink:BiologicalProcess apoptotic process in bone marrow cell The apoptotic process in cells in the bone marrow. go.json apoptosis in bone marrow|bone marrow cell apoptosis|bone marrow cell programmed cell death by apoptosis|killing of bone marrow cells|programmed cell death of bone marrow cells by apoptosis|programmed cell death, bone marrow cells http://purl.obolibrary.org/obo/GO_0071839 GO:0140098 biolink:MolecularActivity catalytic activity, acting on RNA Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. go.json http://purl.obolibrary.org/obo/GO_0140098 goslim_generic|prokaryote_subset GO:0071838 biolink:BiologicalProcess cell proliferation in bone marrow The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow. go.json bone marrow cell proliferation http://purl.obolibrary.org/obo/GO_0071838 GO:0140097 biolink:MolecularActivity catalytic activity, acting on DNA Catalytic activity that acts to modify DNA. go.json http://purl.obolibrary.org/obo/GO_0140097 goslim_generic|prokaryote_subset GO:0071837 biolink:MolecularActivity HMG box domain binding Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. go.json http://purl.obolibrary.org/obo/GO_0071837 GO:0071836 biolink:BiologicalProcess nectar secretion The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins. go.json nectar production http://purl.obolibrary.org/obo/GO_0071836 GO:0071835 biolink:BiologicalProcess mating pheromone secretion involved in regulation of conjugation with cellular fusion The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms. go.json mating pheromone secretion involved in regulation of conjugation|mating-type pheromone secretion involved in conjugation|peptide pheromone export involved in regulation of conjugation http://purl.obolibrary.org/obo/GO_0071835 GO:0071834 biolink:BiologicalProcess mating pheromone secretion The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction. go.json mating-type pheromone secretion http://purl.obolibrary.org/obo/GO_0071834 GO:0071833 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071833 GO:0071832 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071832 GO:0022821 biolink:MolecularActivity solute:potassium antiporter activity Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. go.json potassium ion antiporter activity http://purl.obolibrary.org/obo/GO_0022821 GO:0071831 biolink:BiologicalProcess intermediate-density lipoprotein particle clearance The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json IDL clearance http://purl.obolibrary.org/obo/GO_0071831 GO:0022824 biolink:MolecularActivity transmitter-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. go.json ionotropic neurotransmitter receptor activity|transmitter-gated ion channel activity http://purl.obolibrary.org/obo/GO_0022824 GO:0140090 biolink:MolecularActivity membrane curvature sensor activity Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins. go.json http://purl.obolibrary.org/obo/GO_0140090 GO:0071830 biolink:BiologicalProcess triglyceride-rich lipoprotein particle clearance The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. go.json http://purl.obolibrary.org/obo/GO_0071830 GO:0140092 biolink:CellularComponent bBAF complex A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. go.json brain-specific BAF complex|brain-specific SWI/SNF complex http://purl.obolibrary.org/obo/GO_0140092 GO:0140091 biolink:CellularComponent mBAF complex A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof. go.json muscle-specific BAF complex|muscle-specific SWI/SNF complex|muscle-type BAF complex|muscle-type SWI/SNF complex http://purl.obolibrary.org/obo/GO_0140091 GO:0022825 biolink:MolecularActivity obsolete copper-exporting ATPase activity OBSOLETE. (Was not defined before being made obsolete). go.json copper-exporting ATPase activity True http://purl.obolibrary.org/obo/GO_0022825 GO:0022828 biolink:MolecularActivity phosphorylation-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts. go.json http://purl.obolibrary.org/obo/GO_0022828 GO:0140093 biolink:CellularComponent esBAF complex An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C. go.json embryonic stem cell-specific BAF complex|embryonic stem cell-specific SWI/SNF complex http://purl.obolibrary.org/obo/GO_0140093 GO:1900979 biolink:BiologicalProcess positive regulation of tatiopterin metabolic process Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process. go.json activation of tatiopterin metabolic process|activation of tatiopterin metabolism|positive regulation of tatiopterin metabolism|up regulation of tatiopterin metabolic process|up regulation of tatiopterin metabolism|up-regulation of tatiopterin metabolic process|up-regulation of tatiopterin metabolism|upregulation of tatiopterin metabolic process|upregulation of tatiopterin metabolism http://purl.obolibrary.org/obo/GO_1900979 GO:1900976 biolink:BiologicalProcess positive regulation of tatiopterin biosynthetic process Any process that activates or increases the frequency, rate or extent of tatiopterin biosynthetic process. go.json activation of tatiopterin anabolism|activation of tatiopterin biosynthesis|activation of tatiopterin biosynthetic process|activation of tatiopterin formation|activation of tatiopterin synthesis|positive regulation of tatiopterin anabolism|positive regulation of tatiopterin biosynthesis|positive regulation of tatiopterin formation|positive regulation of tatiopterin synthesis|up regulation of tatiopterin anabolism|up regulation of tatiopterin biosynthesis|up regulation of tatiopterin biosynthetic process|up regulation of tatiopterin formation|up regulation of tatiopterin synthesis|up-regulation of tatiopterin anabolism|up-regulation of tatiopterin biosynthesis|up-regulation of tatiopterin biosynthetic process|up-regulation of tatiopterin formation|up-regulation of tatiopterin synthesis|upregulation of tatiopterin anabolism|upregulation of tatiopterin biosynthesis|upregulation of tatiopterin biosynthetic process|upregulation of tatiopterin formation|upregulation of tatiopterin synthesis http://purl.obolibrary.org/obo/GO_1900976 GO:1900975 biolink:BiologicalProcess negative regulation of tatiopterin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin biosynthetic process. go.json down regulation of tatiopterin anabolism|down regulation of tatiopterin biosynthesis|down regulation of tatiopterin biosynthetic process|down regulation of tatiopterin formation|down regulation of tatiopterin synthesis|down-regulation of tatiopterin anabolism|down-regulation of tatiopterin biosynthesis|down-regulation of tatiopterin biosynthetic process|down-regulation of tatiopterin formation|down-regulation of tatiopterin synthesis|downregulation of tatiopterin anabolism|downregulation of tatiopterin biosynthesis|downregulation of tatiopterin biosynthetic process|downregulation of tatiopterin formation|downregulation of tatiopterin synthesis|inhibition of tatiopterin anabolism|inhibition of tatiopterin biosynthesis|inhibition of tatiopterin biosynthetic process|inhibition of tatiopterin formation|inhibition of tatiopterin synthesis|negative regulation of tatiopterin anabolism|negative regulation of tatiopterin biosynthesis|negative regulation of tatiopterin formation|negative regulation of tatiopterin synthesis http://purl.obolibrary.org/obo/GO_1900975 GO:1900978 biolink:BiologicalProcess negative regulation of tatiopterin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin metabolic process. go.json down regulation of tatiopterin metabolic process|down regulation of tatiopterin metabolism|down-regulation of tatiopterin metabolic process|down-regulation of tatiopterin metabolism|downregulation of tatiopterin metabolic process|downregulation of tatiopterin metabolism|inhibition of tatiopterin metabolic process|inhibition of tatiopterin metabolism|negative regulation of tatiopterin metabolism http://purl.obolibrary.org/obo/GO_1900978 GO:1900977 biolink:BiologicalProcess regulation of tatiopterin metabolic process Any process that modulates the frequency, rate or extent of tatiopterin metabolic process. go.json regulation of tatiopterin metabolism http://purl.obolibrary.org/obo/GO_1900977 GO:1900972 biolink:BiologicalProcess negative regulation of sarcinapterin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process. go.json down regulation of sarcinapterin anabolism|down regulation of sarcinapterin biosynthesis|down regulation of sarcinapterin biosynthetic process|down regulation of sarcinapterin formation|down regulation of sarcinapterin synthesis|down-regulation of sarcinapterin anabolism|down-regulation of sarcinapterin biosynthesis|down-regulation of sarcinapterin biosynthetic process|down-regulation of sarcinapterin formation|down-regulation of sarcinapterin synthesis|downregulation of sarcinapterin anabolism|downregulation of sarcinapterin biosynthesis|downregulation of sarcinapterin biosynthetic process|downregulation of sarcinapterin formation|downregulation of sarcinapterin synthesis|inhibition of sarcinapterin anabolism|inhibition of sarcinapterin biosynthesis|inhibition of sarcinapterin biosynthetic process|inhibition of sarcinapterin formation|inhibition of sarcinapterin synthesis|negative regulation of sarcinapterin anabolism|negative regulation of sarcinapterin biosynthesis|negative regulation of sarcinapterin formation|negative regulation of sarcinapterin synthesis http://purl.obolibrary.org/obo/GO_1900972 GO:1900971 biolink:BiologicalProcess regulation of sarcinapterin biosynthetic process Any process that modulates the frequency, rate or extent of sarcinapterin biosynthetic process. go.json regulation of sarcinapterin anabolism|regulation of sarcinapterin biosynthesis|regulation of sarcinapterin formation|regulation of sarcinapterin synthesis http://purl.obolibrary.org/obo/GO_1900971 GO:1900974 biolink:BiologicalProcess regulation of tatiopterin biosynthetic process Any process that modulates the frequency, rate or extent of tatiopterin biosynthetic process. go.json regulation of tatiopterin anabolism|regulation of tatiopterin biosynthesis|regulation of tatiopterin formation|regulation of tatiopterin synthesis http://purl.obolibrary.org/obo/GO_1900974 GO:1900973 biolink:BiologicalProcess positive regulation of sarcinapterin biosynthetic process Any process that activates or increases the frequency, rate or extent of sarcinapterin biosynthetic process. go.json activation of sarcinapterin anabolism|activation of sarcinapterin biosynthesis|activation of sarcinapterin biosynthetic process|activation of sarcinapterin formation|activation of sarcinapterin synthesis|positive regulation of sarcinapterin anabolism|positive regulation of sarcinapterin biosynthesis|positive regulation of sarcinapterin formation|positive regulation of sarcinapterin synthesis|up regulation of sarcinapterin anabolism|up regulation of sarcinapterin biosynthesis|up regulation of sarcinapterin biosynthetic process|up regulation of sarcinapterin formation|up regulation of sarcinapterin synthesis|up-regulation of sarcinapterin anabolism|up-regulation of sarcinapterin biosynthesis|up-regulation of sarcinapterin biosynthetic process|up-regulation of sarcinapterin formation|up-regulation of sarcinapterin synthesis|upregulation of sarcinapterin anabolism|upregulation of sarcinapterin biosynthesis|upregulation of sarcinapterin biosynthetic process|upregulation of sarcinapterin formation|upregulation of sarcinapterin synthesis http://purl.obolibrary.org/obo/GO_1900973 GO:1900970 biolink:BiologicalProcess positive regulation of sarcinapterin metabolic process Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process. go.json activation of sarcinapterin metabolic process|activation of sarcinapterin metabolism|positive regulation of sarcinapterin metabolism|up regulation of sarcinapterin metabolic process|up regulation of sarcinapterin metabolism|up-regulation of sarcinapterin metabolic process|up-regulation of sarcinapterin metabolism|upregulation of sarcinapterin metabolic process|upregulation of sarcinapterin metabolism http://purl.obolibrary.org/obo/GO_1900970 GO:0022819 biolink:MolecularActivity potassium ion uniporter activity Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. go.json http://purl.obolibrary.org/obo/GO_0022819 GO:0022818 biolink:MolecularActivity sodium ion uniporter activity Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. go.json http://purl.obolibrary.org/obo/GO_0022818 GO:0071869 biolink:BiologicalProcess response to catecholamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. go.json response to catecholamine stimulus http://purl.obolibrary.org/obo/GO_0071869 GO:0071868 biolink:BiologicalProcess cellular response to monoamine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. go.json http://purl.obolibrary.org/obo/GO_0071868 GO:0071867 biolink:BiologicalProcess response to monoamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. go.json response to monoamine stimulus http://purl.obolibrary.org/obo/GO_0071867 GO:0071866 biolink:BiologicalProcess negative regulation of apoptotic process in bone marrow cell Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow. go.json down regulation of apoptosis in bone marrow|down-regulation of apoptosis in bone marrow|downregulation of apoptosis in bone marrow|inhibition of apoptosis in bone marrow|negative regulation of apoptosis in bone marrow|negative regulation of apoptotic process in bone marrow|negative regulation of bone marrow cell apoptosis|negative regulation of bone marrow cell programmed cell death by apoptosis|negative regulation of killing of bone marrow cells|negative regulation of programmed cell death of bone marrow cells by apoptosis|negative regulation of programmed cell death, bone marrow cells http://purl.obolibrary.org/obo/GO_0071866 GO:0071865 biolink:BiologicalProcess regulation of apoptotic process in bone marrow cell Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow. go.json regulation of apoptosis in bone marrow|regulation of apoptotic process in bone marrow http://purl.obolibrary.org/obo/GO_0071865 GO:0022810 biolink:MolecularActivity membrane potential driven uniporter activity Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. go.json porter http://purl.obolibrary.org/obo/GO_0022810 GO:0071864 biolink:BiologicalProcess positive regulation of cell proliferation in bone marrow A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. go.json activation of cell proliferation in bone marrow|positive regulation of bone marrow cell proliferation|stimulation of cell proliferation in bone marrow|up regulation of cell proliferation in bone marrow|up-regulation of cell proliferation in bone marrow|upregulation of cell proliferation in bone marrow http://purl.obolibrary.org/obo/GO_0071864 GO:0071863 biolink:BiologicalProcess regulation of cell proliferation in bone marrow A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow. go.json regulation of bone marrow cell proliferation http://purl.obolibrary.org/obo/GO_0071863 GO:0071862 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071862 GO:0022815 biolink:MolecularActivity obsolete large uncharged polar molecule transmembrane transporter activity OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other. go.json large uncharged polar molecule transmembrane transporter activity True http://purl.obolibrary.org/obo/GO_0022815 GO:0071861 biolink:MolecularActivity tachykinin receptor binding Binding to a tachykinin receptor. go.json http://purl.obolibrary.org/obo/GO_0071861 GO:0022814 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022814 GO:0071860 biolink:MolecularActivity proctolin receptor binding Binding to a proctolin receptor. go.json http://purl.obolibrary.org/obo/GO_0071860 GO:0022817 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022817 GO:0022816 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022816 GO:1900987 biolink:BiologicalProcess obsolete ajmaline catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ajmaline. go.json ajmaline breakdown|ajmaline catabolism|ajmaline degradation True http://purl.obolibrary.org/obo/GO_1900987 GO:1900986 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900986 GO:1900989 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900989 GO:1900988 biolink:BiologicalProcess ajmaline biosynthetic process The chemical reactions and pathways resulting in the formation of ajmaline. go.json ajmaline anabolism|ajmaline biosynthesis|ajmaline formation|ajmaline metabolic process|ajmaline metabolism|ajmaline synthesis http://purl.obolibrary.org/obo/GO_1900988 GO:1900983 biolink:BiologicalProcess vindoline metabolic process The chemical reactions and pathways involving vindoline. go.json vindoline metabolism http://purl.obolibrary.org/obo/GO_1900983 GO:1900982 biolink:BiologicalProcess positive regulation of phenazine biosynthetic process Any process that activates or increases the frequency, rate or extent of phenazine biosynthetic process. go.json activation of acridizine biosynthesis|activation of acridizine biosynthetic process|activation of azophenylene biosynthesis|activation of azophenylene biosynthetic process|activation of dibenzo-p-diazine biosynthesis|activation of dibenzo-p-diazine biosynthetic process|activation of dibenzopyrazine biosynthesis|activation of dibenzopyrazine biosynthetic process|activation of phenazine biosynthetic process|positive regulation of acridizine biosynthesis|positive regulation of acridizine biosynthetic process|positive regulation of azophenylene biosynthesis|positive regulation of azophenylene biosynthetic process|positive regulation of dibenzo-p-diazine biosynthesis|positive regulation of dibenzo-p-diazine biosynthetic process|positive regulation of dibenzopyrazine biosynthesis|positive regulation of dibenzopyrazine biosynthetic process|up regulation of acridizine biosynthesis|up regulation of acridizine biosynthetic process|up regulation of azophenylene biosynthesis|up regulation of azophenylene biosynthetic process|up regulation of dibenzo-p-diazine biosynthesis|up regulation of dibenzo-p-diazine biosynthetic process|up regulation of dibenzopyrazine biosynthesis|up regulation of dibenzopyrazine biosynthetic process|up regulation of phenazine biosynthetic process|up-regulation of acridizine biosynthesis|up-regulation of acridizine biosynthetic process|up-regulation of azophenylene biosynthesis|up-regulation of azophenylene biosynthetic process|up-regulation of dibenzo-p-diazine biosynthesis|up-regulation of dibenzo-p-diazine biosynthetic process|up-regulation of dibenzopyrazine biosynthesis|up-regulation of dibenzopyrazine biosynthetic process|up-regulation of phenazine biosynthetic process|upregulation of acridizine biosynthesis|upregulation of acridizine biosynthetic process|upregulation of azophenylene biosynthesis|upregulation of azophenylene biosynthetic process|upregulation of dibenzo-p-diazine biosynthesis|upregulation of dibenzo-p-diazine biosynthetic process|upregulation of dibenzopyrazine biosynthesis|upregulation of dibenzopyrazine biosynthetic process|upregulation of phenazine biosynthetic process http://purl.obolibrary.org/obo/GO_1900982 GO:1900985 biolink:BiologicalProcess vindoline biosynthetic process The chemical reactions and pathways resulting in the formation of vindoline. MetaCyc:PWY-5292 go.json vindoline anabolism|vindoline biosynthesis|vindoline formation|vindoline synthesis http://purl.obolibrary.org/obo/GO_1900985 GO:1900984 biolink:BiologicalProcess obsolete vindoline catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of vindoline. go.json vindoline breakdown|vindoline catabolism|vindoline degradation True http://purl.obolibrary.org/obo/GO_1900984 GO:1900981 biolink:BiologicalProcess negative regulation of phenazine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process. go.json down regulation of acridizine biosynthesis|down regulation of acridizine biosynthetic process|down regulation of azophenylene biosynthesis|down regulation of azophenylene biosynthetic process|down regulation of dibenzo-p-diazine biosynthesis|down regulation of dibenzo-p-diazine biosynthetic process|down regulation of dibenzopyrazine biosynthesis|down regulation of dibenzopyrazine biosynthetic process|down regulation of phenazine biosynthetic process|down-regulation of acridizine biosynthesis|down-regulation of acridizine biosynthetic process|down-regulation of azophenylene biosynthesis|down-regulation of azophenylene biosynthetic process|down-regulation of dibenzo-p-diazine biosynthesis|down-regulation of dibenzo-p-diazine biosynthetic process|down-regulation of dibenzopyrazine biosynthesis|down-regulation of dibenzopyrazine biosynthetic process|down-regulation of phenazine biosynthetic process|downregulation of acridizine biosynthesis|downregulation of acridizine biosynthetic process|downregulation of azophenylene biosynthesis|downregulation of azophenylene biosynthetic process|downregulation of dibenzo-p-diazine biosynthesis|downregulation of dibenzo-p-diazine biosynthetic process|downregulation of dibenzopyrazine biosynthesis|downregulation of dibenzopyrazine biosynthetic process|downregulation of phenazine biosynthetic process|inhibition of acridizine biosynthesis|inhibition of acridizine biosynthetic process|inhibition of azophenylene biosynthesis|inhibition of azophenylene biosynthetic process|inhibition of dibenzo-p-diazine biosynthesis|inhibition of dibenzo-p-diazine biosynthetic process|inhibition of dibenzopyrazine biosynthesis|inhibition of dibenzopyrazine biosynthetic process|inhibition of phenazine biosynthetic process|negative regulation of acridizine biosynthesis|negative regulation of acridizine biosynthetic process|negative regulation of azophenylene biosynthesis|negative regulation of azophenylene biosynthetic process|negative regulation of dibenzo-p-diazine biosynthesis|negative regulation of dibenzo-p-diazine biosynthetic process|negative regulation of dibenzopyrazine biosynthesis|negative regulation of dibenzopyrazine biosynthetic process http://purl.obolibrary.org/obo/GO_1900981 GO:1900980 biolink:BiologicalProcess regulation of phenazine biosynthetic process Any process that modulates the frequency, rate or extent of phenazine biosynthetic process. go.json regulation of acridizine biosynthesis|regulation of acridizine biosynthetic process|regulation of azophenylene biosynthesis|regulation of azophenylene biosynthetic process|regulation of dibenzo-p-diazine biosynthesis|regulation of dibenzo-p-diazine biosynthetic process|regulation of dibenzopyrazine biosynthesis|regulation of dibenzopyrazine biosynthetic process http://purl.obolibrary.org/obo/GO_1900980 GO:0022809 biolink:MolecularActivity mobile ion carrier activity Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane. go.json ionophore http://purl.obolibrary.org/obo/GO_0022809 GO:0071859 biolink:MolecularActivity neuropeptide F receptor binding Binding to a neuropeptide F receptor. go.json http://purl.obolibrary.org/obo/GO_0071859 GO:0071858 biolink:MolecularActivity corazonin receptor binding Binding to a corazonin receptor. go.json http://purl.obolibrary.org/obo/GO_0071858 GO:0071857 biolink:MolecularActivity beta-endorphin receptor binding Binding to a beta-endorphin receptor. go.json http://purl.obolibrary.org/obo/GO_0071857 GO:0071856 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071856 GO:0071855 biolink:MolecularActivity neuropeptide receptor binding Binding to a neuropeptide receptor. go.json http://purl.obolibrary.org/obo/GO_0071855 GO:0071854 biolink:BiologicalProcess cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall. go.json http://purl.obolibrary.org/obo/GO_0071854 GO:0071853 biolink:BiologicalProcess fungal-type cell wall disassembly A cellular process that results in the breakdown of a fungal-type cell wall. go.json http://purl.obolibrary.org/obo/GO_0071853 GO:0071852 biolink:BiologicalProcess fungal-type cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall. go.json fungal-type cell wall organisation or biogenesis|fungal-type cell wall organization and biogenesis http://purl.obolibrary.org/obo/GO_0071852 GO:0071851 biolink:BiologicalProcess obsolete mitotic G1 cell cycle arrest in response to nitrogen starvation OBSOLETE. The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen. go.json G1 mitotic cell cycle arrest in response to nitrogen starvation True http://purl.obolibrary.org/obo/GO_0071851 GO:0022804 biolink:MolecularActivity active transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. go.json active carrier activity|carrier activity|permease activity|pump activity http://purl.obolibrary.org/obo/GO_0022804 GO:0022803 biolink:MolecularActivity passive transmembrane transporter activity Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged. Reactome:R-HSA-429767|Wikipedia:Facilitated_diffusion go.json facilitated diffusion|porters|uniporter activity z http://purl.obolibrary.org/obo/GO_0022803 GO:0071850 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071850 GO:0032272 biolink:BiologicalProcess negative regulation of protein polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. go.json down regulation of protein polymerization|down-regulation of protein polymerization|downregulation of protein polymerization|inhibition of protein polymerization http://purl.obolibrary.org/obo/GO_0032272 GO:0032271 biolink:BiologicalProcess regulation of protein polymerization Any process that modulates the frequency, rate or extent of the process of creating protein polymers. go.json regulation of protein polymerisation http://purl.obolibrary.org/obo/GO_0032271 GO:0032270 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032270 GO:0032279 biolink:CellularComponent asymmetric synapse A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. go.json Gray's type I synapse http://purl.obolibrary.org/obo/GO_0032279 GO:0032278 biolink:BiologicalProcess positive regulation of gonadotropin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin. go.json activation of gonadotropin secretion|positive regulation of gonadotrophin secretion|stimulation of gonadotropin secretion|up regulation of gonadotropin secretion|up-regulation of gonadotropin secretion|upregulation of gonadotropin secretion http://purl.obolibrary.org/obo/GO_0032278 GO:0032277 biolink:BiologicalProcess negative regulation of gonadotropin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin. go.json down regulation of gonadotropin secretion|down-regulation of gonadotropin secretion|downregulation of gonadotropin secretion|inhibition of gonadotropin secretion|negative regulation of gonadotrophin secretion http://purl.obolibrary.org/obo/GO_0032277 GO:0032276 biolink:BiologicalProcess regulation of gonadotropin secretion Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. go.json regulation of gonadotrophin secretion http://purl.obolibrary.org/obo/GO_0032276 GO:0032275 biolink:BiologicalProcess luteinizing hormone secretion The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. go.json http://purl.obolibrary.org/obo/GO_0032275 GO:0032274 biolink:BiologicalProcess gonadotropin secretion The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone. go.json gonadotrophin secretion http://purl.obolibrary.org/obo/GO_0032274 GO:0032273 biolink:BiologicalProcess positive regulation of protein polymerization Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. go.json activation of protein polymerization|stimulation of protein polymerization|up regulation of protein polymerization|up-regulation of protein polymerization|upregulation of protein polymerization http://purl.obolibrary.org/obo/GO_0032273 GO:0032261 biolink:BiologicalProcess purine nucleotide salvage Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0032261 GO:0032260 biolink:BiologicalProcess response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. go.json response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance http://purl.obolibrary.org/obo/GO_0032260 GO:0032269 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032269 GO:0032268 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032268 GO:0032267 biolink:MolecularActivity tRNA(Ile)-lysidine synthase activity Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine. EC:6.3.4.- go.json tRNA(Ile)-2-lysyl-cytidine synthase activity|tRNA(Ile)-lysidine synthetase activity http://purl.obolibrary.org/obo/GO_0032267 GO:0032266 biolink:MolecularActivity phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. go.json PtdIns-3-P binding|phosphatidylinositol 3-phosphate binding http://purl.obolibrary.org/obo/GO_0032266 GO:0032265 biolink:BiologicalProcess XMP salvage Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0032265 GO:0032264 biolink:BiologicalProcess IMP salvage Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0032264 GO:0032263 biolink:BiologicalProcess GMP salvage Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0032263 GO:0032262 biolink:BiologicalProcess pyrimidine nucleotide salvage Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis. go.json http://purl.obolibrary.org/obo/GO_0032262 GO:0032259 biolink:BiologicalProcess methylation The process in which a methyl group is covalently attached to a molecule. Wikipedia:Methylation go.json http://purl.obolibrary.org/obo/GO_0032259 goslim_chembl GO:0007299 biolink:BiologicalProcess follicle cell of egg chamber-cell adhesion The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster. go.json follicle cell adhesion|ovarian follicle cell adhesion http://purl.obolibrary.org/obo/GO_0007299 GO:0007298 biolink:BiologicalProcess border follicle cell migration The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster. go.json border cell migration http://purl.obolibrary.org/obo/GO_0007298 GO:0007297 biolink:BiologicalProcess follicle cell of egg chamber migration The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster. go.json follicle cell migration http://purl.obolibrary.org/obo/GO_0007297 GO:0007296 biolink:BiologicalProcess vitellogenesis The production of yolk. Yolk is a mixture of materials used for embryonic nutrition. Wikipedia:Vitellogenesis go.json yolk formation|yolk production http://purl.obolibrary.org/obo/GO_0007296 GO:0007295 biolink:BiologicalProcess growth of a germarium-derived egg chamber Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster. go.json egg chamber growth http://purl.obolibrary.org/obo/GO_0007295 GO:0032250 biolink:BiologicalProcess negative regulation of adenosine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of adenosine transport|down-regulation of adenosine transport|downregulation of adenosine transport|inhibition of adenosine transport http://purl.obolibrary.org/obo/GO_0032250 GO:0032258 biolink:BiologicalProcess cytoplasm to vacuole transport by the Cvt pathway A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast. go.json cytoplasm to vacuole targeting|cytoplasm-to-vacuole targeting|protein localization by the Cvt pathway http://purl.obolibrary.org/obo/GO_0032258 GO:0032257 biolink:BiologicalProcess maintenance of dense core granule location Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of dense core granule localization|maintenance of dense core vesicle location http://purl.obolibrary.org/obo/GO_0032257 GO:0032256 biolink:BiologicalProcess establishment of dense core granule localization The directed movement of a dense core granule to a specific location. go.json establishment of dense core granule localisation|establishment of dense core vesicle localization http://purl.obolibrary.org/obo/GO_0032256 GO:0032255 biolink:BiologicalProcess maintenance of secretory granule location Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere. go.json maintenance of secretory granule localization http://purl.obolibrary.org/obo/GO_0032255 GO:0032254 biolink:BiologicalProcess establishment of secretory granule localization The directed movement of a secretory granule to a specific location. go.json establishment of secretory granule localisation http://purl.obolibrary.org/obo/GO_0032254 GO:0032253 biolink:BiologicalProcess dense core granule localization Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. go.json dense core granule clustering|dense core granule localisation|dense core vesicle localization http://purl.obolibrary.org/obo/GO_0032253 GO:0032252 biolink:BiologicalProcess secretory granule localization Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. go.json secretory granule clustering|secretory granule localisation http://purl.obolibrary.org/obo/GO_0032252 GO:0032251 biolink:BiologicalProcess positive regulation of adenosine transport Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of adenosine transport|stimulation of adenosine transport|up regulation of adenosine transport|up-regulation of adenosine transport|upregulation of adenosine transport http://purl.obolibrary.org/obo/GO_0032251 GO:0032249 biolink:BiologicalProcess regulation of adenosine transport Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032249 GO:0032248 biolink:BiologicalProcess positive regulation of purine nucleoside transport Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of purine nucleoside transport|stimulation of purine nucleoside transport|up regulation of purine nucleoside transport|up-regulation of purine nucleoside transport|upregulation of purine nucleoside transport http://purl.obolibrary.org/obo/GO_0032248 GO:0032247 biolink:BiologicalProcess negative regulation of purine nucleoside transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of purine nucleoside transport|down-regulation of purine nucleoside transport|downregulation of purine nucleoside transport|inhibition of purine nucleoside transport http://purl.obolibrary.org/obo/GO_0032247 GO:0032246 biolink:BiologicalProcess regulation of pyrimidine nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032246 GO:0032245 biolink:BiologicalProcess regulation of purine nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032245 GO:0032244 biolink:BiologicalProcess positive regulation of nucleoside transport Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of nucleoside transport|stimulation of nucleoside transport|up regulation of nucleoside transport|up-regulation of nucleoside transport|upregulation of nucleoside transport http://purl.obolibrary.org/obo/GO_0032244 GO:0032243 biolink:BiologicalProcess negative regulation of nucleoside transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of nucleoside transport|down-regulation of nucleoside transport|downregulation of nucleoside transport|inhibition of nucleoside transport http://purl.obolibrary.org/obo/GO_0032243 GO:0032242 biolink:BiologicalProcess regulation of nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032242 GO:0032241 biolink:BiologicalProcess positive regulation of nucleobase-containing compound transport Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of nucleobase, nucleoside, nucleotide and nucleic acid transport|positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport http://purl.obolibrary.org/obo/GO_0032241 GO:0032240 biolink:BiologicalProcess negative regulation of nucleobase-containing compound transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport http://purl.obolibrary.org/obo/GO_0032240 GO:0032239 biolink:BiologicalProcess regulation of nucleobase-containing compound transport Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport http://purl.obolibrary.org/obo/GO_0032239 GO:0032238 biolink:BiologicalProcess adenosine transport The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032238 GO:0032237 biolink:BiologicalProcess activation of store-operated calcium channel activity A process that initiates the activity of an inactive store-operated calcium channel. go.json http://purl.obolibrary.org/obo/GO_0032237 gocheck_do_not_annotate GO:0046800 biolink:BiologicalProcess obsolete enhancement of virulence OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease. go.json enhancement of virulence True http://purl.obolibrary.org/obo/GO_0046800 GO:0007279 biolink:BiologicalProcess pole cell formation Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells. go.json http://purl.obolibrary.org/obo/GO_0007279 GO:0007278 biolink:BiologicalProcess pole cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0007278 GO:0007277 biolink:BiologicalProcess pole cell development The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure. go.json http://purl.obolibrary.org/obo/GO_0007277 GO:0007276 biolink:BiologicalProcess gamete generation The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. go.json gametogenesis http://purl.obolibrary.org/obo/GO_0007276 GO:0007275 biolink:BiologicalProcess multicellular organism development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). go.json http://purl.obolibrary.org/obo/GO_0007275 gocheck_do_not_annotate|goslim_chembl|goslim_plant GO:0007274 biolink:BiologicalProcess neuromuscular synaptic transmission The process of synaptic transmission from a neuron to a muscle, across a synapse. go.json http://purl.obolibrary.org/obo/GO_0007274 GO:0007273 biolink:BiologicalProcess obsolete regulation of synapse OBSOLETE. (Was not defined before being made obsolete). go.json regulation of synapse True http://purl.obolibrary.org/obo/GO_0007273 GO:0007283 biolink:BiologicalProcess spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. Wikipedia:Spermatogenesis go.json generation of spermatozoa http://purl.obolibrary.org/obo/GO_0007283 GO:0046808 biolink:CellularComponent obsolete assemblon OBSOLETE. Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously. go.json True http://purl.obolibrary.org/obo/GO_0046808 GO:0007282 biolink:BiologicalProcess cystoblast division Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells. go.json cystoblast cell division http://purl.obolibrary.org/obo/GO_0007282 GO:0046807 biolink:BiologicalProcess viral scaffold assembly and maintenance The assembly and maintenance of the viral scaffold around which the viral capsid is constructed. go.json http://purl.obolibrary.org/obo/GO_0046807 GO:0046806 biolink:CellularComponent viral scaffold A complex of proteins that form a scaffold around which the viral capsid is constructed. go.json http://purl.obolibrary.org/obo/GO_0046806 GO:0007281 biolink:BiologicalProcess germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. go.json gametogenesis|germ-cell development|primordial germ cell development http://purl.obolibrary.org/obo/GO_0007281 GO:0007280 biolink:BiologicalProcess pole cell migration The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form. go.json http://purl.obolibrary.org/obo/GO_0007280 GO:0046805 biolink:BiologicalProcess protein-heme linkage via 1'-L-histidine The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine). RESID:AA0329 go.json protein-haem linkage via 1'-L-histidine http://purl.obolibrary.org/obo/GO_0046805 gocheck_do_not_annotate GO:0046804 biolink:BiologicalProcess peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine. RESID:AA0330 go.json peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide http://purl.obolibrary.org/obo/GO_0046804 gocheck_do_not_annotate GO:0046803 biolink:BiologicalProcess obsolete reduction of virulence OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease. go.json reduction of virulence True http://purl.obolibrary.org/obo/GO_0046803 GO:0046802 biolink:BiologicalProcess exit of virus from host cell nucleus by nuclear egress The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm. VZ:1952 go.json capsid egress|egress of viral procapsid from host cell nucleus|nuclear egress|nuclear egress of viral procapsid http://purl.obolibrary.org/obo/GO_0046802 GO:0046801 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046801 GO:0032236 biolink:BiologicalProcess obsolete positive regulation of calcium ion transport via store-operated calcium channel activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel. go.json activation of calcium ion transport via store-operated calcium channel|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of calcium transport via store-operated calcium channel|positive regulation of store-operated calcium channel activity|stimulation of calcium ion transport via store-operated calcium channel|up regulation of calcium ion transport via store-operated calcium channel|up-regulation of calcium ion transport via store-operated calcium channel|upregulation of calcium ion transport via store-operated calcium channel True http://purl.obolibrary.org/obo/GO_0032236 GO:0032235 biolink:BiologicalProcess obsolete negative regulation of calcium ion transport via store-operated calcium channel activity OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel. go.json down regulation of calcium ion transport via store-operated calcium channel|down-regulation of calcium ion transport via store-operated calcium channel|downregulation of calcium ion transport via store-operated calcium channel|inhibition of calcium ion transport via store-operated calcium channel|negative regulation of calcium ion transport via store-operated calcium channel activity|negative regulation of calcium transport via store-operated calcium channel|negative regulation of store-operated calcium channel activity True http://purl.obolibrary.org/obo/GO_0032235 GO:0032234 biolink:BiologicalProcess obsolete regulation of calcium ion transport via store-operated calcium channel activity OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel. go.json regulation of calcium ion transport via store-operated calcium channel activity|regulation of calcium transport via store-operated calcium channel|regulation of store-operated calcium channel activity True http://purl.obolibrary.org/obo/GO_0032234 GO:0032233 biolink:BiologicalProcess positive regulation of actin filament bundle assembly Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. go.json activation of actin filament bundle formation|stimulation of actin filament bundle formation|up regulation of actin filament bundle formation|up-regulation of actin filament bundle formation|upregulation of actin filament bundle formation http://purl.obolibrary.org/obo/GO_0032233 GO:0032232 biolink:BiologicalProcess negative regulation of actin filament bundle assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. go.json down regulation of actin filament bundle formation|down-regulation of actin filament bundle formation|downregulation of actin filament bundle formation|inhibition of actin filament bundle formation http://purl.obolibrary.org/obo/GO_0032232 GO:0032231 biolink:BiologicalProcess regulation of actin filament bundle assembly Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. go.json regulation of actin cable assembly|regulation of actin filament bundle formation http://purl.obolibrary.org/obo/GO_0032231 GO:0032230 biolink:BiologicalProcess positive regulation of synaptic transmission, GABAergic Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). go.json activation of synaptic transmission, GABAergic|stimulation of synaptic transmission, GABAergic|up regulation of synaptic transmission, GABAergic|up-regulation of synaptic transmission, GABAergic|upregulation of synaptic transmission, GABAergic http://purl.obolibrary.org/obo/GO_0032230 GO:0046809 biolink:CellularComponent replication compartment Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously. go.json RC http://purl.obolibrary.org/obo/GO_0046809 GO:0032229 biolink:BiologicalProcess negative regulation of synaptic transmission, GABAergic Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). go.json down regulation of synaptic transmission, GABAergic|down-regulation of synaptic transmission, GABAergic|downregulation of synaptic transmission, GABAergic|inhibition of synaptic transmission, GABAergic http://purl.obolibrary.org/obo/GO_0032229 GO:0032228 biolink:BiologicalProcess regulation of synaptic transmission, GABAergic Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). go.json http://purl.obolibrary.org/obo/GO_0032228 GO:0032227 biolink:BiologicalProcess negative regulation of synaptic transmission, dopaminergic Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. go.json down regulation of synaptic transmission, dopaminergic|down-regulation of synaptic transmission, dopaminergic|downregulation of synaptic transmission, dopaminergic|inhibition of synaptic transmission, dopaminergic http://purl.obolibrary.org/obo/GO_0032227 GO:0032226 biolink:BiologicalProcess positive regulation of synaptic transmission, dopaminergic Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. go.json activation of synaptic transmission, dopaminergic|stimulation of synaptic transmission, dopaminergic|up regulation of synaptic transmission, dopaminergic|up-regulation of synaptic transmission, dopaminergic|upregulation of synaptic transmission, dopaminergic http://purl.obolibrary.org/obo/GO_0032226 GO:0046811 biolink:MolecularActivity histone deacetylase inhibitor activity Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. go.json http://purl.obolibrary.org/obo/GO_0046811 GO:0046810 biolink:MolecularActivity host cell extracellular matrix binding Binding to the extracellular matrix of a host cell. go.json http://purl.obolibrary.org/obo/GO_0046810 GO:0007289 biolink:BiologicalProcess spermatid nucleus differentiation The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. go.json spermatid nuclear differentiation http://purl.obolibrary.org/obo/GO_0007289 GO:0007288 biolink:BiologicalProcess sperm axoneme assembly The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. go.json http://purl.obolibrary.org/obo/GO_0007288 GO:0007287 biolink:BiologicalProcess Nebenkern assembly Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern. go.json Nebenkern formation http://purl.obolibrary.org/obo/GO_0007287 GO:0007286 biolink:BiologicalProcess spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. Wikipedia:Spermiogenesis go.json spermatid cell development|spermiogenesis http://purl.obolibrary.org/obo/GO_0007286 GO:0007285 biolink:BiologicalProcess primary spermatocyte growth The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis. go.json http://purl.obolibrary.org/obo/GO_0007285 GO:0007284 biolink:BiologicalProcess spermatogonial cell division The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes). go.json spermatogonium division http://purl.obolibrary.org/obo/GO_0007284 GO:0046819 biolink:BiologicalProcess protein secretion by the type V secretion system The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway. go.json autotransporter system|protein secretion by the autotransporter system|protein secretion by the type V protein secretion system|type V protein secretion system http://purl.obolibrary.org/obo/GO_0046819 GO:0007294 biolink:BiologicalProcess germarium-derived oocyte fate determination The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster. go.json maintenance of oocyte identity|oocyte cell fate determination http://purl.obolibrary.org/obo/GO_0007294 GO:0046818 biolink:CellularComponent dense nuclear body A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously. go.json http://purl.obolibrary.org/obo/GO_0046818 GO:0007293 biolink:BiologicalProcess germarium-derived egg chamber formation Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007293 GO:0046817 biolink:MolecularActivity chemokine receptor antagonist activity Interacts with chemokine receptors to reduce the action of a chemokine. go.json http://purl.obolibrary.org/obo/GO_0046817 GO:0007292 biolink:BiologicalProcess female gamete generation Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. go.json http://purl.obolibrary.org/obo/GO_0007292 GO:0046816 biolink:CellularComponent virion transport vesicle A vesicle used to transport the partial or complete virion between cellular compartments. go.json http://purl.obolibrary.org/obo/GO_0046816 GO:0007291 biolink:BiologicalProcess sperm individualization The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0007291 GO:0046815 biolink:BiologicalProcess obsolete genome retention in viral capsid OBSOLETE. Any process in which the viral genome is retained within the capsid during genome cleavage and packaging. go.json True http://purl.obolibrary.org/obo/GO_0046815 GO:0007290 biolink:BiologicalProcess spermatid nucleus elongation The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation. go.json spermatid nuclear elongation http://purl.obolibrary.org/obo/GO_0007290 GO:0046814 biolink:BiologicalProcess coreceptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface. go.json virion attachment, binding of host cell surface coreceptor http://purl.obolibrary.org/obo/GO_0046814 GO:0046813 biolink:BiologicalProcess receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface. go.json virion attachment, binding of host cell surface receptor http://purl.obolibrary.org/obo/GO_0046813 GO:0046812 biolink:MolecularActivity host cell surface binding Binding to the surface of a host cell. go.json http://purl.obolibrary.org/obo/GO_0046812 goslim_pir GO:0032225 biolink:BiologicalProcess regulation of synaptic transmission, dopaminergic Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. go.json http://purl.obolibrary.org/obo/GO_0032225 GO:0032224 biolink:BiologicalProcess positive regulation of synaptic transmission, cholinergic Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. go.json activation of synaptic transmission, cholinergic|stimulation of synaptic transmission, cholinergic|up regulation of synaptic transmission, cholinergic|up-regulation of synaptic transmission, cholinergic|upregulation of synaptic transmission, cholinergic http://purl.obolibrary.org/obo/GO_0032224 GO:0032223 biolink:BiologicalProcess negative regulation of synaptic transmission, cholinergic Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. go.json down regulation of synaptic transmission, cholinergic|down-regulation of synaptic transmission, cholinergic|downregulation of synaptic transmission, cholinergic|inhibition of synaptic transmission, cholinergic http://purl.obolibrary.org/obo/GO_0032223 GO:0032222 biolink:BiologicalProcess regulation of synaptic transmission, cholinergic Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. go.json http://purl.obolibrary.org/obo/GO_0032222 GO:0032221 biolink:CellularComponent Rpd3S complex A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species). go.json Clr6 histone deacetylase complex II|Clr6 histone deacetylase complex II'|Clr6-CII complex|Clr6S complex|Rpd3C(S)|Rpd3S|Sin3S http://purl.obolibrary.org/obo/GO_0032221 GO:0032220 biolink:BiologicalProcess plasma membrane fusion involved in cytogamy The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy. go.json plasma membrane fusion during cytogamy|plasma membrane organization involved in conjugation with cellular fusion http://purl.obolibrary.org/obo/GO_0032220 GO:0022891 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022891 GO:0022890 biolink:MolecularActivity inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. go.json di-, tri-valent inorganic cation transmembrane transporter activity|divalent inorganic cation transmembrane transporter activity|monovalent inorganic cation transmembrane transporter activity|trivalent inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022890 GO:0022893 biolink:MolecularActivity low-affinity tryptophan transmembrane transporter activity Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. go.json low-affinity tryptophan permease activity http://purl.obolibrary.org/obo/GO_0022893 GO:0032219 biolink:BiologicalProcess cell wall macromolecule catabolic process involved in cytogamy The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy. go.json cell wall macromolecule catabolic process during cytogamy http://purl.obolibrary.org/obo/GO_0032219 GO:0022892 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022892 GO:0032218 biolink:BiologicalProcess riboflavin transport The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. go.json http://purl.obolibrary.org/obo/GO_0032218 GO:0022895 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0022895 GO:0032217 biolink:MolecularActivity riboflavin transmembrane transporter activity Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. RHEA:35015|Reactome:R-HSA-3165230 go.json riboflavin transporter activity http://purl.obolibrary.org/obo/GO_0032217 GO:0022894 biolink:MolecularActivity Intermediate conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. go.json IK KCa channels|IK calcium-activated potassium channel activity|intermdiate conductance KCa channels http://purl.obolibrary.org/obo/GO_0022894 GO:0022897 biolink:MolecularActivity proton-dependent peptide secondary active transmembrane transporter activity Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. go.json hydrogen/oligopeptide symporter http://purl.obolibrary.org/obo/GO_0022897 GO:0032216 biolink:MolecularActivity glucosaminyl-phosphatidylinositol O-acyltransferase activity Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA. go.json GPI-inositol acyltransferase|glucosaminyl-phosphotidylinositol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0032216 GO:0032215 biolink:BiologicalProcess positive regulation of telomere maintenance via semi-conservative replication Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA. go.json activation of telomere maintenance via semi-conservative replication|stimulation of telomere maintenance via semi-conservative replication|up regulation of telomere maintenance via semi-conservative replication|up-regulation of telomere maintenance via semi-conservative replication|upregulation of telomere maintenance via semi-conservative replication http://purl.obolibrary.org/obo/GO_0032215 GO:0007259 biolink:BiologicalProcess receptor signaling pathway via JAK-STAT Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. Wikipedia:JAK-STAT_signaling_pathway go.json JAK-STAT cascade|JAK-STAT signal transduction http://purl.obolibrary.org/obo/GO_0007259 GO:0046822 biolink:BiologicalProcess regulation of nucleocytoplasmic transport Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. go.json http://purl.obolibrary.org/obo/GO_0046822 GO:0007258 biolink:BiologicalProcess JUN phosphorylation The process of introducing a phosphate group into a JUN protein. go.json http://purl.obolibrary.org/obo/GO_0007258 gocheck_do_not_annotate GO:0046821 biolink:CellularComponent extrachromosomal DNA DNA structures that are not part of a chromosome. Wikipedia:Extrachromosomal_DNA go.json http://purl.obolibrary.org/obo/GO_0046821 GO:0007257 biolink:BiologicalProcess obsolete activation of JUN kinase activity OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase (JNK). go.json activation of SAPK activity True http://purl.obolibrary.org/obo/GO_0007257 GO:0046820 biolink:MolecularActivity 4-amino-4-deoxychorismate synthase activity Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. EC:2.6.1.85|KEGG_REACTION:R01716|MetaCyc:PABASYN-RXN|RHEA:11672 go.json ADC synthase activity|PabB activity|aminodeoxychorismate synthase activity|chorismate:L-glutamine amido-ligase activity|p-aminobenzoate synthetase|para-aminobenzoic acid (PABA) synthase|para-aminobenzoic acid synthase activity http://purl.obolibrary.org/obo/GO_0046820 GO:0007256 biolink:BiologicalProcess obsolete activation of JNKK activity OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress. go.json activation of JUN kinase kinase activity|positive regulation of JUNKK activity True http://purl.obolibrary.org/obo/GO_0007256 GO:0007255 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007255 GO:0007254 biolink:BiologicalProcess JNK cascade An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. go.json JNK1 cascade|JNK2 cascade|JNK3 cascade|MAPK10 cascade|MAPK8 cascade|MAPK9 cascade|SAPK cascade|c-Jun N-terminal kinase cascade|stress-activated protein kinase cascade http://purl.obolibrary.org/obo/GO_0007254 GO:0007253 biolink:BiologicalProcess cytoplasmic sequestering of NF-kappaB The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. go.json cytoplasmic NF-kappaB retention|cytoplasmic NF-kappaB sequestration|cytoplasmic NF-kappaB storage|cytoplasmic retention of NF-kappaB|cytoplasmic sequestration of NF-kappaB|cytoplasmic storage of NF-kappaB|maintenance of NF-kappaB location in cytoplasm http://purl.obolibrary.org/obo/GO_0007253 gocheck_do_not_annotate GO:0007252 biolink:BiologicalProcess I-kappaB phosphorylation The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. go.json IKB phosphorylation|IkappaB phosphorylation|inhibitor of NF-kappaB phosphorylation|inhibitor of kappaB phosphorylation http://purl.obolibrary.org/obo/GO_0007252 gocheck_do_not_annotate GO:0007251 biolink:BiologicalProcess obsolete activation of the inhibitor of kappa kinase OBSOLETE. (Was not defined before being made obsolete). go.json activation of the inhibitor of kappa kinase True http://purl.obolibrary.org/obo/GO_0007251 GO:0007261 biolink:BiologicalProcess obsolete JAK-induced STAT protein dimerization OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases. go.json JAK-induced STAT protein dimerization True http://purl.obolibrary.org/obo/GO_0007261 GO:0007260 biolink:BiologicalProcess tyrosine phosphorylation of STAT protein The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. go.json tyrosine phosphorylation of Stat1 protein|tyrosine phosphorylation of Stat2 protein|tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat4 protein|tyrosine phosphorylation of Stat5 protein|tyrosine phosphorylation of Stat6 protein|tyrosine phosphorylation of Stat7 protein http://purl.obolibrary.org/obo/GO_0007260 gocheck_do_not_annotate GO:0046829 biolink:BiologicalProcess negative regulation of RNA import into nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus. go.json down regulation of RNA import into nucleus|down-regulation of RNA import into nucleus|downregulation of RNA import into nucleus|inhibition of RNA import into nucleus|negative regulation of RNA import into cell nucleus|negative regulation of RNA transport from cytoplasm to nucleus|negative regulation of RNA-nucleus import http://purl.obolibrary.org/obo/GO_0046829 GO:0046828 biolink:BiologicalProcess regulation of RNA import into nucleus Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus. go.json regulation of RNA import into cell nucleus|regulation of RNA transport from cytoplasm to nucleus|regulation of RNA-nucleus import http://purl.obolibrary.org/obo/GO_0046828 GO:0046827 biolink:BiologicalProcess positive regulation of protein export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. go.json activation of protein export from nucleus|positive regulation of protein export from cell nucleus|positive regulation of protein export out of nucleus|positive regulation of protein transport from nucleus to cytoplasm|positive regulation of protein-nucleus export|stimulation of protein export from nucleus|up regulation of protein export from nucleus|up-regulation of protein export from nucleus|upregulation of protein export from nucleus http://purl.obolibrary.org/obo/GO_0046827 GO:0046826 biolink:BiologicalProcess negative regulation of protein export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. go.json down regulation of protein export from nucleus|down-regulation of protein export from nucleus|downregulation of protein export from nucleus|inhibition of protein export from nucleus|negative regulation of protein export from cell nucleus|negative regulation of protein export out of nucleus|negative regulation of protein transport from nucleus to cytoplasm|negative regulation of protein-nucleus export http://purl.obolibrary.org/obo/GO_0046826 GO:0046825 biolink:BiologicalProcess regulation of protein export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. go.json regulation of protein export from cell nucleus|regulation of protein export out of nucleus|regulation of protein transport from nucleus to cytoplasm|regulation of protein-nucleus export http://purl.obolibrary.org/obo/GO_0046825 GO:0046824 biolink:BiologicalProcess positive regulation of nucleocytoplasmic transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. go.json activation of nucleocytoplasmic transport|stimulation of nucleocytoplasmic transport|up regulation of nucleocytoplasmic transport|up-regulation of nucleocytoplasmic transport|upregulation of nucleocytoplasmic transport http://purl.obolibrary.org/obo/GO_0046824 GO:0046823 biolink:BiologicalProcess negative regulation of nucleocytoplasmic transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. go.json down regulation of nucleocytoplasmic transport|down-regulation of nucleocytoplasmic transport|downregulation of nucleocytoplasmic transport|inhibition of nucleocytoplasmic transport http://purl.obolibrary.org/obo/GO_0046823 GO:0032214 biolink:BiologicalProcess negative regulation of telomere maintenance via semi-conservative replication Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA. go.json down regulation of telomere maintenance via semi-conservative replication|down-regulation of telomere maintenance via semi-conservative replication|downregulation of telomere maintenance via semi-conservative replication|inhibition of telomere maintenance via semi-conservative replication http://purl.obolibrary.org/obo/GO_0032214 GO:0032213 biolink:BiologicalProcess regulation of telomere maintenance via semi-conservative replication Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA. go.json http://purl.obolibrary.org/obo/GO_0032213 GO:0022898 biolink:BiologicalProcess regulation of transmembrane transporter activity Any process that modulates the frequency, rate or extent of transmembrane transporter activity. go.json http://purl.obolibrary.org/obo/GO_0022898 gocheck_do_not_annotate GO:0032212 biolink:BiologicalProcess positive regulation of telomere maintenance via telomerase Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. go.json activation of telomere maintenance via telomerase|stimulation of telomere maintenance via telomerase|up regulation of telomere maintenance via telomerase activity|up-regulation of telomere maintenance via telomerase activity|upregulation of telomere maintenance via telomerase activity http://purl.obolibrary.org/obo/GO_0032212 GO:0032211 biolink:BiologicalProcess negative regulation of telomere maintenance via telomerase Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. go.json down regulation of telomere maintenance via telomerase activity|down-regulation of telomere maintenance via telomerase activity|downregulation of telomere maintenance via telomerase activity|inhibition of telomere maintenance via telomerase http://purl.obolibrary.org/obo/GO_0032211 GO:0032210 biolink:BiologicalProcess regulation of telomere maintenance via telomerase Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. go.json http://purl.obolibrary.org/obo/GO_0032210 GO:1900903 biolink:BiologicalProcess negative regulation of hexadecanal biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal biosynthetic process. go.json down regulation of hexadecanal anabolism|down regulation of hexadecanal biosynthesis|down regulation of hexadecanal biosynthetic process|down regulation of hexadecanal formation|down regulation of hexadecanal synthesis|down regulation of palmitaldehyde biosynthesis|down regulation of palmitaldehyde biosynthetic process|down-regulation of hexadecanal anabolism|down-regulation of hexadecanal biosynthesis|down-regulation of hexadecanal biosynthetic process|down-regulation of hexadecanal formation|down-regulation of hexadecanal synthesis|down-regulation of palmitaldehyde biosynthesis|down-regulation of palmitaldehyde biosynthetic process|downregulation of hexadecanal anabolism|downregulation of hexadecanal biosynthesis|downregulation of hexadecanal biosynthetic process|downregulation of hexadecanal formation|downregulation of hexadecanal synthesis|downregulation of palmitaldehyde biosynthesis|downregulation of palmitaldehyde biosynthetic process|inhibition of hexadecanal anabolism|inhibition of hexadecanal biosynthesis|inhibition of hexadecanal biosynthetic process|inhibition of hexadecanal formation|inhibition of hexadecanal synthesis|inhibition of palmitaldehyde biosynthesis|inhibition of palmitaldehyde biosynthetic process|negative regulation of hexadecanal anabolism|negative regulation of hexadecanal biosynthesis|negative regulation of hexadecanal formation|negative regulation of hexadecanal synthesis|negative regulation of palmitaldehyde biosynthesis|negative regulation of palmitaldehyde biosynthetic process http://purl.obolibrary.org/obo/GO_1900903 GO:0022880 biolink:MolecularActivity protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json N-acetylglucosamine PTS transporter activity http://purl.obolibrary.org/obo/GO_0022880 GO:1900902 biolink:BiologicalProcess regulation of hexadecanal biosynthetic process Any process that modulates the frequency, rate or extent of hexadecanal biosynthetic process. go.json regulation of hexadecanal anabolism|regulation of hexadecanal biosynthesis|regulation of hexadecanal formation|regulation of hexadecanal synthesis|regulation of palmitaldehyde biosynthesis|regulation of palmitaldehyde biosynthetic process http://purl.obolibrary.org/obo/GO_1900902 GO:0032209 biolink:BiologicalProcess positive regulation of telomere maintenance via recombination Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. go.json activation of telomere maintenance via recombination|stimulation of telomere maintenance via recombination|up regulation of telomere maintenance via recombination|up-regulation of telomere maintenance via recombination|upregulation of telomere maintenance via recombination http://purl.obolibrary.org/obo/GO_0032209 GO:1900905 biolink:BiologicalProcess regulation of hexadecanal metabolic process Any process that modulates the frequency, rate or extent of hexadecanal metabolic process. go.json regulation of hexadecanal metabolism http://purl.obolibrary.org/obo/GO_1900905 GO:0022882 biolink:MolecularActivity protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json beta-glucoside PTS transporter activity http://purl.obolibrary.org/obo/GO_0022882 GO:1900904 biolink:BiologicalProcess positive regulation of hexadecanal biosynthetic process Any process that activates or increases the frequency, rate or extent of hexadecanal biosynthetic process. go.json activation of hexadecanal anabolism|activation of hexadecanal biosynthesis|activation of hexadecanal biosynthetic process|activation of hexadecanal formation|activation of hexadecanal synthesis|activation of palmitaldehyde biosynthesis|activation of palmitaldehyde biosynthetic process|positive regulation of hexadecanal anabolism|positive regulation of hexadecanal biosynthesis|positive regulation of hexadecanal formation|positive regulation of hexadecanal synthesis|positive regulation of palmitaldehyde biosynthesis|positive regulation of palmitaldehyde biosynthetic process|up regulation of hexadecanal anabolism|up regulation of hexadecanal biosynthesis|up regulation of hexadecanal biosynthetic process|up regulation of hexadecanal formation|up regulation of hexadecanal synthesis|up regulation of palmitaldehyde biosynthesis|up regulation of palmitaldehyde biosynthetic process|up-regulation of hexadecanal anabolism|up-regulation of hexadecanal biosynthesis|up-regulation of hexadecanal biosynthetic process|up-regulation of hexadecanal formation|up-regulation of hexadecanal synthesis|up-regulation of palmitaldehyde biosynthesis|up-regulation of palmitaldehyde biosynthetic process|upregulation of hexadecanal anabolism|upregulation of hexadecanal biosynthesis|upregulation of hexadecanal biosynthetic process|upregulation of hexadecanal formation|upregulation of hexadecanal synthesis|upregulation of palmitaldehyde biosynthesis|upregulation of palmitaldehyde biosynthetic process http://purl.obolibrary.org/obo/GO_1900904 GO:0022881 biolink:MolecularActivity protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. go.json N-acetylgalactosamine PTS transporter activity http://purl.obolibrary.org/obo/GO_0022881 GO:0032208 biolink:BiologicalProcess negative regulation of telomere maintenance via recombination Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. go.json down regulation of telomere maintenance via recombination|down-regulation of telomere maintenance via recombination|downregulation of telomere maintenance via recombination|inhibition of telomere maintenance via recombination http://purl.obolibrary.org/obo/GO_0032208 GO:0032207 biolink:BiologicalProcess regulation of telomere maintenance via recombination Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. go.json http://purl.obolibrary.org/obo/GO_0032207 GO:0022884 biolink:MolecularActivity macromolecule transmembrane transporter activity Enables the transfer of a macromolecule from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0022884 GO:0032206 biolink:BiologicalProcess positive regulation of telomere maintenance Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. go.json activation of telomere maintenance|stimulation of telomere maintenance|up regulation of telomere maintenance|up-regulation of telomere maintenance|upregulation of telomere maintenance http://purl.obolibrary.org/obo/GO_0032206 GO:0022883 biolink:MolecularActivity zinc efflux transmembrane transporter activity Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane. go.json zinc efflux permease activity http://purl.obolibrary.org/obo/GO_0022883 GO:0032205 biolink:BiologicalProcess negative regulation of telomere maintenance Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. go.json down regulation of telomere maintenance|down-regulation of telomere maintenance|downregulation of telomere maintenance|inhibition of telomere maintenance http://purl.obolibrary.org/obo/GO_0032205 GO:1900901 biolink:BiologicalProcess positive regulation of heptadecane metabolic process Any process that activates or increases the frequency, rate or extent of heptadecane metabolic process. go.json activation of heptadecane metabolic process|activation of heptadecane metabolism|positive regulation of heptadecane metabolism|up regulation of heptadecane metabolic process|up regulation of heptadecane metabolism|up-regulation of heptadecane metabolic process|up-regulation of heptadecane metabolism|upregulation of heptadecane metabolic process|upregulation of heptadecane metabolism http://purl.obolibrary.org/obo/GO_1900901 GO:0022886 biolink:MolecularActivity channel-forming ionophore activity Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive. go.json ionophore activity http://purl.obolibrary.org/obo/GO_0022886 GO:1900900 biolink:BiologicalProcess negative regulation of heptadecane metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane metabolic process. go.json down regulation of heptadecane metabolic process|down regulation of heptadecane metabolism|down-regulation of heptadecane metabolic process|down-regulation of heptadecane metabolism|downregulation of heptadecane metabolic process|downregulation of heptadecane metabolism|inhibition of heptadecane metabolic process|inhibition of heptadecane metabolism|negative regulation of heptadecane metabolism http://purl.obolibrary.org/obo/GO_1900900 GO:0032204 biolink:BiologicalProcess regulation of telomere maintenance Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. go.json http://purl.obolibrary.org/obo/GO_0032204 GO:0022885 biolink:MolecularActivity bacteriocin transmembrane transporter activity Enables the transfer of a bacteriocin from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0022885 GO:0007269 biolink:BiologicalProcess neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. go.json neurotransmitter release|neurotransmitter secretory pathway http://purl.obolibrary.org/obo/GO_0007269 goslim_synapse GO:0046833 biolink:BiologicalProcess positive regulation of RNA export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. go.json activation of RNA export from nucleus|positive regulation of RNA export from cell nucleus|positive regulation of RNA export out of nucleus|positive regulation of RNA transport from nucleus to cytoplasm|positive regulation of RNA-nucleus export|stimulation of RNA export from nucleus|up regulation of RNA export from nucleus|up-regulation of RNA export from nucleus|upregulation of RNA export from nucleus http://purl.obolibrary.org/obo/GO_0046833 GO:0007268 biolink:BiologicalProcess chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. Wikipedia:Neurotransmission go.json neurotransmission|signal transmission across a synapse|synaptic transmission http://purl.obolibrary.org/obo/GO_0007268 goslim_synapse GO:0046832 biolink:BiologicalProcess negative regulation of RNA export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm. go.json down regulation of RNA export from nucleus|down-regulation of RNA export from nucleus|downregulation of RNA export from nucleus|inhibition of RNA export from nucleus|negative regulation of RNA export from cell nucleus|negative regulation of RNA export out of nucleus|negative regulation of RNA transport from nucleus to cytoplasm|negative regulation of RNA-nucleus export http://purl.obolibrary.org/obo/GO_0046832 GO:0046831 biolink:BiologicalProcess regulation of RNA export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm. go.json regulation of RNA export from cell nucleus|regulation of RNA export out of nucleus|regulation of RNA transport from nucleus to cytoplasm|regulation of RNA-nucleus export http://purl.obolibrary.org/obo/GO_0046831 GO:0007267 biolink:BiologicalProcess cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. go.json cell-cell signalling http://purl.obolibrary.org/obo/GO_0007267 goslim_chembl|goslim_plant GO:0046830 biolink:BiologicalProcess positive regulation of RNA import into nucleus Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus. go.json activation of RNA import into nucleus|positive regulation of RNA import into cell nucleus|positive regulation of RNA transport from cytoplasm to nucleus|positive regulation of RNA-nucleus import|stimulation of RNA import into nucleus|up regulation of RNA import into nucleus|up-regulation of RNA import into nucleus|upregulation of RNA import into nucleus http://purl.obolibrary.org/obo/GO_0046830 GO:0007266 biolink:BiologicalProcess Rho protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. go.json Rho mediated signal transduction http://purl.obolibrary.org/obo/GO_0007266 GO:0007265 biolink:BiologicalProcess Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. go.json Ras mediated signal transduction http://purl.obolibrary.org/obo/GO_0007265 GO:0007264 biolink:BiologicalProcess small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal. go.json small GTPase-mediated signal transduction http://purl.obolibrary.org/obo/GO_0007264 GO:0007263 biolink:BiologicalProcess nitric oxide mediated signal transduction Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. go.json NO mediated signal transduction|NO-mediated signal transduction|nitric oxide signaling|nitric oxide-mediated signal transduction http://purl.obolibrary.org/obo/GO_0007263 GO:0007262 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007262 GO:0007272 biolink:BiologicalProcess ensheathment of neurons The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. go.json ionic insulation of neurons by glial cells http://purl.obolibrary.org/obo/GO_0007272 GO:0007271 biolink:BiologicalProcess synaptic transmission, cholinergic The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. go.json cholinergic synaptic transmission http://purl.obolibrary.org/obo/GO_0007271 GO:0046839 biolink:BiologicalProcess phospholipid dephosphorylation The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. go.json http://purl.obolibrary.org/obo/GO_0046839 GO:0007270 biolink:BiologicalProcess neuron-neuron synaptic transmission The process of synaptic transmission from a neuron to another neuron across a synapse. go.json nerve-nerve synaptic transmission http://purl.obolibrary.org/obo/GO_0007270 GO:0046838 biolink:BiologicalProcess obsolete phosphorylated carbohydrate dephosphorylation OBSOLETE. The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it. go.json True http://purl.obolibrary.org/obo/GO_0046838 GO:0046837 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046837 GO:0046836 biolink:BiologicalProcess glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0046836 GO:0046835 biolink:BiologicalProcess carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. go.json http://purl.obolibrary.org/obo/GO_0046835 GO:0046834 biolink:BiologicalProcess lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. go.json http://purl.obolibrary.org/obo/GO_0046834 GO:0032203 biolink:BiologicalProcess telomere formation via telomerase A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme. go.json http://purl.obolibrary.org/obo/GO_0032203 GO:0032202 biolink:BiologicalProcess telomere assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins. go.json telomere formation http://purl.obolibrary.org/obo/GO_0032202 GO:0032201 biolink:BiologicalProcess telomere maintenance via semi-conservative replication The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication. go.json equal telomere replication|telomeric fork progression|telomeric replication fork progression http://purl.obolibrary.org/obo/GO_0032201 GO:0032200 biolink:BiologicalProcess telomere organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. go.json chromosome organization, telomeric|organization of chromosome, telomeric region|telomere organisation|telomere organization and biogenesis http://purl.obolibrary.org/obo/GO_0032200 goslim_generic|goslim_pombe|goslim_yeast GO:0022889 biolink:MolecularActivity serine transmembrane transporter activity Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. RHEA:35031 go.json http://purl.obolibrary.org/obo/GO_0022889 GO:1900907 biolink:BiologicalProcess positive regulation of hexadecanal metabolic process Any process that activates or increases the frequency, rate or extent of hexadecanal metabolic process. go.json activation of hexadecanal metabolic process|activation of hexadecanal metabolism|positive regulation of hexadecanal metabolism|up regulation of hexadecanal metabolic process|up regulation of hexadecanal metabolism|up-regulation of hexadecanal metabolic process|up-regulation of hexadecanal metabolism|upregulation of hexadecanal metabolic process|upregulation of hexadecanal metabolism http://purl.obolibrary.org/obo/GO_1900907 GO:1900906 biolink:BiologicalProcess negative regulation of hexadecanal metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal metabolic process. go.json down regulation of hexadecanal metabolic process|down regulation of hexadecanal metabolism|down-regulation of hexadecanal metabolic process|down-regulation of hexadecanal metabolism|downregulation of hexadecanal metabolic process|downregulation of hexadecanal metabolism|inhibition of hexadecanal metabolic process|inhibition of hexadecanal metabolism|negative regulation of hexadecanal metabolism http://purl.obolibrary.org/obo/GO_1900906 GO:1900909 biolink:BiologicalProcess negative regulation of olefin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process. go.json down regulation of olefin metabolic process|down regulation of olefin metabolism|down-regulation of olefin metabolic process|down-regulation of olefin metabolism|downregulation of olefin metabolic process|downregulation of olefin metabolism|inhibition of olefin metabolic process|inhibition of olefin metabolism|negative regulation of olefin metabolism http://purl.obolibrary.org/obo/GO_1900909 GO:1900908 biolink:BiologicalProcess regulation of olefin metabolic process Any process that modulates the frequency, rate or extent of olefin metabolic process. go.json regulation of olefin metabolism http://purl.obolibrary.org/obo/GO_1900908 GO:0140104 biolink:MolecularActivity molecular carrier activity Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. go.json http://purl.obolibrary.org/obo/GO_0140104 gocheck_do_not_annotate|goslim_generic|prokaryote_subset GO:0140103 biolink:MolecularActivity catalytic activity, acting on a glycoprotein Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. go.json http://purl.obolibrary.org/obo/GO_0140103 GO:0140105 biolink:BiologicalProcess interleukin-10-mediated signaling pathway The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json IL-10-mediated signaling pathway|interleukin-10-mediated signalling pathway http://purl.obolibrary.org/obo/GO_0140105 GO:0140108 biolink:MolecularActivity high-affinity glucose transmembrane transporter activity Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json http://purl.obolibrary.org/obo/GO_0140108 GO:0140107 biolink:MolecularActivity high-affinity potassium ion transmembrane transporter activity Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. go.json http://purl.obolibrary.org/obo/GO_0140107 GO:0140102 biolink:MolecularActivity catalytic activity, acting on a rRNA Catalytic activity that acts to modify a ribosomal RNA. go.json http://purl.obolibrary.org/obo/GO_0140102 GO:0140101 biolink:MolecularActivity catalytic activity, acting on a tRNA Catalytic activity that acts to modify a tRNA. go.json http://purl.obolibrary.org/obo/GO_0140101 GO:0140125 biolink:BiologicalProcess thiamine import across plasma membrane The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140125 GO:0140122 biolink:BiologicalProcess regulation of Lewy body formation Any process that modulates the frequency, rate or extent of Lewy body formation. go.json http://purl.obolibrary.org/obo/GO_0140122 GO:0140121 biolink:BiologicalProcess Lewy body formation The aggregation, arrangement and bonding together of a set of components to form a Lewy body. go.json http://purl.obolibrary.org/obo/GO_0140121 GO:0140124 biolink:BiologicalProcess positive regulation of Lewy body formation Any process that activates or increases the frequency, rate or extent of Lewy body formation. go.json http://purl.obolibrary.org/obo/GO_0140124 GO:0140123 biolink:BiologicalProcess negative regulation of Lewy body formation Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation. go.json http://purl.obolibrary.org/obo/GO_0140123 GO:0140115 biolink:BiologicalProcess export across plasma membrane The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region. go.json efflux http://purl.obolibrary.org/obo/GO_0140115 GO:0140114 biolink:BiologicalProcess cellular detoxification of fluoride Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. go.json http://purl.obolibrary.org/obo/GO_0140114 GO:0140116 biolink:BiologicalProcess fluoride export across plasma membrane The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json http://purl.obolibrary.org/obo/GO_0140116 GO:0140111 biolink:MolecularActivity [choline trimethylamine-lyase]-activating enzyme activity Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM). MetaCyc:RXN-16470 go.json http://purl.obolibrary.org/obo/GO_0140111 GO:0140110 biolink:MolecularActivity transcription regulator activity A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons. go.json http://purl.obolibrary.org/obo/GO_0140110 gocheck_do_not_annotate|goslim_flybase_ribbon|goslim_generic|goslim_plant GO:0140113 biolink:BiologicalProcess extracellular microvesicle biogenesis The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding. go.json extracellular microvesicle assembly http://purl.obolibrary.org/obo/GO_0140113 GO:0140112 biolink:BiologicalProcess extracellular vesicle biogenesis The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. go.json extracellular vesicle assembly http://purl.obolibrary.org/obo/GO_0140112 GO:0032195 biolink:CellularComponent post-lysosomal vacuole A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. go.json post-lysosome|postlysosome http://purl.obolibrary.org/obo/GO_0032195 GO:0032194 biolink:BiologicalProcess ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate. go.json http://purl.obolibrary.org/obo/GO_0032194 GO:0032193 biolink:BiologicalProcess ubiquinone biosynthetic process via 2-polyprenylphenol The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol. go.json http://purl.obolibrary.org/obo/GO_0032193 GO:0032192 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032192 GO:0032191 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032191 GO:0032190 biolink:MolecularActivity acrosin binding Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. go.json acrosin heavy chain binding|acrosin light chain binding http://purl.obolibrary.org/obo/GO_0032190 GO:0032199 biolink:BiologicalProcess obsolete reverse transcription involved in RNA-mediated transposition OBSOLETE. The synthesis of DNA from an RNA transposon intermediate. go.json reverse transcription during retrotransposition True http://purl.obolibrary.org/obo/GO_0032199 GO:0032198 biolink:BiologicalProcess obsolete MITE transposition OBSOLETE. Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs). go.json True http://purl.obolibrary.org/obo/GO_0032198 GO:0032197 biolink:BiologicalProcess retrotransposition A type of transposition in which a transposable element (transposon) copies and pastes itself into a different genomic location by transcription and convertsion of the transcribed RNA back into DNA through reverse transcription. Wikipedia:Transposon##Class_I:_Retrotransposons go.json Class I transposition|RNA-mediated transposition|Tf transposition|Ty element transposition|Ty1 element transposition|Ty2 element transposition|Ty3 element transposition|retrotransposon transposition|transposition via RNA intermediate|transposition, RNA-mediated http://purl.obolibrary.org/obo/GO_0032197 GO:0032196 biolink:BiologicalProcess transposition Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site. Wikipedia:Transposon go.json http://purl.obolibrary.org/obo/GO_0032196 goslim_candida|goslim_chembl|goslim_pir|goslim_yeast GO:0032184 biolink:MolecularActivity SUMO polymer binding Binding to a polymer of the small ubiquitin-like protein SUMO. go.json Smt3 polymer binding http://purl.obolibrary.org/obo/GO_0032184 GO:0032183 biolink:MolecularActivity SUMO binding Binding to the small ubiquitin-like protein SUMO. go.json Smt3 binding|Smt3 monomer binding http://purl.obolibrary.org/obo/GO_0032183 GO:0032182 biolink:MolecularActivity ubiquitin-like protein binding Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. go.json small conjugating protein binding http://purl.obolibrary.org/obo/GO_0032182 goslim_chembl|goslim_yeast GO:0032181 biolink:MolecularActivity dinucleotide repeat insertion binding Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. go.json http://purl.obolibrary.org/obo/GO_0032181 GO:0032180 biolink:BiologicalProcess ubiquinone biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate. go.json http://purl.obolibrary.org/obo/GO_0032180 GO:0032189 biolink:BiologicalProcess obsolete maintenance of actomyosin contractile ring localization OBSOLETE. Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere. go.json cytokinetic ring anchoring|maintenance of contractile ring localisation involved in cell cycle cytokinesis|maintenance of contractile ring localization involved in cell cycle cytokinesis|maintenance of contractile ring localization involved in cytokinesis during cell cycle True http://purl.obolibrary.org/obo/GO_0032189 GO:0032188 biolink:BiologicalProcess obsolete establishment of actomyosin contractile ring localization OBSOLETE. The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis. go.json actomyosin ring positioning|contractile ring positioning|cytokinesis site selection by contractile ring positioning|establishment of contractile ring localisation involved in cell cycle cytokinesis|establishment of contractile ring localization involved in cell cycle cytokinesis|establishment of contractile ring localization involved in cytokinesis during cell cycle True http://purl.obolibrary.org/obo/GO_0032188 GO:0032187 biolink:BiologicalProcess obsolete actomyosin contractile ring localization OBSOLETE. The process in which a contractile ring is positioned or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle. go.json contractile ring localisation involved in cell cycle cytokinesis|contractile ring localization involved in cell cycle cytokinesis True http://purl.obolibrary.org/obo/GO_0032187 GO:0032186 biolink:BiologicalProcess cellular bud neck septin ring organization Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. go.json cellular bud neck septin ring organisation http://purl.obolibrary.org/obo/GO_0032186 GO:0032185 biolink:BiologicalProcess septin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins. go.json septin cytoskeleton organisation|septin cytoskeleton organization and biogenesis http://purl.obolibrary.org/obo/GO_0032185 GO:0032173 biolink:CellularComponent septin collar A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell. go.json septin hourglass http://purl.obolibrary.org/obo/GO_0032173 GO:0032172 biolink:CellularComponent germ tube septin ring A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. go.json http://purl.obolibrary.org/obo/GO_0032172 GO:0032171 biolink:CellularComponent germ tube septin cap A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. go.json http://purl.obolibrary.org/obo/GO_0032171 GO:0032170 biolink:CellularComponent pseudohyphal septin ring A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins. go.json http://purl.obolibrary.org/obo/GO_0032170 GO:0032179 biolink:CellularComponent germ tube The slender tubular outgrowth first produced by most spores in germination. Wikipedia:Germ_tube go.json http://purl.obolibrary.org/obo/GO_0032179 goslim_pir GO:0032178 biolink:CellularComponent medial membrane band A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum. go.json sterol-rich membrane band http://purl.obolibrary.org/obo/GO_0032178 GO:0032177 biolink:CellularComponent cellular bud neck split septin rings Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated. go.json http://purl.obolibrary.org/obo/GO_0032177 GO:0032176 biolink:CellularComponent split septin rings A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well. go.json http://purl.obolibrary.org/obo/GO_0032176 GO:0032175 biolink:CellularComponent mating projection septin ring A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip. go.json http://purl.obolibrary.org/obo/GO_0032175 GO:0032174 biolink:CellularComponent cellular bud neck septin collar A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck. go.json http://purl.obolibrary.org/obo/GO_0032174 GO:0032162 biolink:CellularComponent mating projection septin band A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection). go.json http://purl.obolibrary.org/obo/GO_0032162 GO:0032161 biolink:CellularComponent cleavage apparatus septin structure Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis. go.json http://purl.obolibrary.org/obo/GO_0032161 GO:0032160 biolink:CellularComponent septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. go.json septin bar http://purl.obolibrary.org/obo/GO_0032160 GO:0032169 biolink:CellularComponent prospore septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins. go.json http://purl.obolibrary.org/obo/GO_0032169 GO:0032168 biolink:CellularComponent hyphal septin ring A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. go.json http://purl.obolibrary.org/obo/GO_0032168 GO:0032167 biolink:CellularComponent obsolete septin patch OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis. go.json septin patch True http://purl.obolibrary.org/obo/GO_0032167 GO:0032166 biolink:CellularComponent chlamydospore septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation. go.json http://purl.obolibrary.org/obo/GO_0032166 GO:0032165 biolink:CellularComponent prospore septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation. go.json http://purl.obolibrary.org/obo/GO_0032165 GO:0032164 biolink:CellularComponent hyphal septin cap A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. go.json http://purl.obolibrary.org/obo/GO_0032164 GO:0032163 biolink:CellularComponent hyphal septin band A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. go.json http://purl.obolibrary.org/obo/GO_0032163 GO:1900877 biolink:BiologicalProcess nonadec-1-ene biosynthetic process The chemical reactions and pathways resulting in the formation of nonadec-1-ene. go.json nonadec-1-ene anabolism|nonadec-1-ene biosynthesis|nonadec-1-ene formation|nonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900877 GO:1900876 biolink:BiologicalProcess nonadec-1-ene metabolic process The chemical reactions and pathways involving nonadec-1-ene. go.json nonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900876 GO:1900879 biolink:BiologicalProcess (Z)-nonadeca-1,14-diene biosynthetic process The chemical reactions and pathways resulting in the formation of (Z)-nonadeca-1,14-diene. go.json (Z)-nonadeca-1,14-diene anabolism|(Z)-nonadeca-1,14-diene biosynthesis|(Z)-nonadeca-1,14-diene formation|(Z)-nonadeca-1,14-diene synthesis http://purl.obolibrary.org/obo/GO_1900879 GO:1900878 biolink:BiologicalProcess (Z)-nonadeca-1,14-diene metabolic process The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene. go.json (Z)-nonadeca-1,14-diene metabolism http://purl.obolibrary.org/obo/GO_1900878 GO:1900873 biolink:BiologicalProcess pentadec-1-ene biosynthetic process The chemical reactions and pathways resulting in the formation of pentadec-1-ene. go.json pentadec-1-ene anabolism|pentadec-1-ene biosynthesis|pentadec-1-ene formation|pentadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900873 GO:1900872 biolink:BiologicalProcess pentadec-1-ene metabolic process The chemical reactions and pathways involving pentadec-1-ene. go.json pentadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900872 GO:1900875 biolink:BiologicalProcess heptadec-1-ene biosynthetic process The chemical reactions and pathways resulting in the formation of heptadec-1-ene. go.json heptadec-1-ene anabolism|heptadec-1-ene biosynthesis|heptadec-1-ene formation|heptadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900875 GO:1900874 biolink:BiologicalProcess heptadec-1-ene metabolic process The chemical reactions and pathways involving heptadec-1-ene. go.json heptadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900874 GO:1900871 biolink:BiologicalProcess chloroplast mRNA modification The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically. go.json chloroplast mRNA editing|mRNA editing in chloroplast http://purl.obolibrary.org/obo/GO_1900871 GO:1900870 biolink:BiologicalProcess tatiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tatiopterin. go.json tatiopterin anabolism|tatiopterin biosynthesis|tatiopterin formation|tatiopterin synthesis http://purl.obolibrary.org/obo/GO_1900870 GO:0071769 biolink:BiologicalProcess mycolate cell wall layer assembly The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer. MetaCyc:PWY-6397 go.json mycolate cell wall layer biogenesis http://purl.obolibrary.org/obo/GO_0071769 GO:0071768 biolink:BiologicalProcess mycolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. MetaCyc:PWYG-321 go.json mycolate biosynthetic process|mycolic acid anabolism|mycolic acid biosynthesis|mycolic acid formation|mycolic acid synthesis http://purl.obolibrary.org/obo/GO_0071768 GO:0071767 biolink:BiologicalProcess mycolic acid metabolic process The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. go.json mycolate metabolic process|mycolic acid metabolism http://purl.obolibrary.org/obo/GO_0071767 GO:0071766 biolink:BiologicalProcess Actinobacterium-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface. go.json http://purl.obolibrary.org/obo/GO_0071766 GO:0071765 biolink:BiologicalProcess nuclear inner membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane. go.json nuclear inner membrane organisation|nuclear inner membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0071765 GO:0071764 biolink:BiologicalProcess nuclear outer membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. go.json nuclear outer membrane organisation|nuclear outer membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0071764 GO:0071763 biolink:BiologicalProcess nuclear membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. go.json nuclear membrane organisation|nuclear membrane organization and biogenesis http://purl.obolibrary.org/obo/GO_0071763 GO:0071762 biolink:CellularComponent heavy chain immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains. go.json HCab|Ig NAR immunoglobulin complex|IgNAR antibody|IgNAR immunoglobulin complex http://purl.obolibrary.org/obo/GO_0071762 GO:0071761 biolink:CellularComponent IgZ immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish. go.json IgT antibody|IgT immunoglobulin complex|IgZ antibody http://purl.obolibrary.org/obo/GO_0071761 GO:0071760 biolink:CellularComponent IgY immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0071760 GO:1900888 biolink:BiologicalProcess negative regulation of pentadecane biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane biosynthetic process. go.json down regulation of pentadecane anabolism|down regulation of pentadecane biosynthesis|down regulation of pentadecane biosynthetic process|down regulation of pentadecane formation|down regulation of pentadecane synthesis|down-regulation of pentadecane anabolism|down-regulation of pentadecane biosynthesis|down-regulation of pentadecane biosynthetic process|down-regulation of pentadecane formation|down-regulation of pentadecane synthesis|downregulation of pentadecane anabolism|downregulation of pentadecane biosynthesis|downregulation of pentadecane biosynthetic process|downregulation of pentadecane formation|downregulation of pentadecane synthesis|inhibition of pentadecane anabolism|inhibition of pentadecane biosynthesis|inhibition of pentadecane biosynthetic process|inhibition of pentadecane formation|inhibition of pentadecane synthesis|negative regulation of pentadecane anabolism|negative regulation of pentadecane biosynthesis|negative regulation of pentadecane formation|negative regulation of pentadecane synthesis http://purl.obolibrary.org/obo/GO_1900888 GO:1900887 biolink:BiologicalProcess regulation of pentadecane biosynthetic process Any process that modulates the frequency, rate or extent of pentadecane biosynthetic process. go.json regulation of pentadecane anabolism|regulation of pentadecane biosynthesis|regulation of pentadecane formation|regulation of pentadecane synthesis http://purl.obolibrary.org/obo/GO_1900887 GO:1900889 biolink:BiologicalProcess positive regulation of pentadecane biosynthetic process Any process that activates or increases the frequency, rate or extent of pentadecane biosynthetic process. go.json activation of pentadecane anabolism|activation of pentadecane biosynthesis|activation of pentadecane biosynthetic process|activation of pentadecane formation|activation of pentadecane synthesis|positive regulation of pentadecane anabolism|positive regulation of pentadecane biosynthesis|positive regulation of pentadecane formation|positive regulation of pentadecane synthesis|up regulation of pentadecane anabolism|up regulation of pentadecane biosynthesis|up regulation of pentadecane biosynthetic process|up regulation of pentadecane formation|up regulation of pentadecane synthesis|up-regulation of pentadecane anabolism|up-regulation of pentadecane biosynthesis|up-regulation of pentadecane biosynthetic process|up-regulation of pentadecane formation|up-regulation of pentadecane synthesis|upregulation of pentadecane anabolism|upregulation of pentadecane biosynthesis|upregulation of pentadecane biosynthetic process|upregulation of pentadecane formation|upregulation of pentadecane synthesis http://purl.obolibrary.org/obo/GO_1900889 GO:1900884 biolink:BiologicalProcess regulation of tridecane biosynthetic process Any process that modulates the frequency, rate or extent of tridecane biosynthetic process. go.json regulation of tridecane anabolism|regulation of tridecane biosynthesis|regulation of tridecane formation|regulation of tridecane synthesis http://purl.obolibrary.org/obo/GO_1900884 GO:1900883 biolink:BiologicalProcess 17-methylnonadec-1-ene biosynthetic process The chemical reactions and pathways resulting in the formation of 17-methylnonadec-1-ene. go.json 17-methylnonadec-1-ene anabolism|17-methylnonadec-1-ene biosynthesis|17-methylnonadec-1-ene formation|17-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900883 GO:1900886 biolink:BiologicalProcess positive regulation of tridecane biosynthetic process Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process. go.json activation of tridecane anabolism|activation of tridecane biosynthesis|activation of tridecane biosynthetic process|activation of tridecane formation|activation of tridecane synthesis|positive regulation of tridecane anabolism|positive regulation of tridecane biosynthesis|positive regulation of tridecane formation|positive regulation of tridecane synthesis|up regulation of tridecane anabolism|up regulation of tridecane biosynthesis|up regulation of tridecane biosynthetic process|up regulation of tridecane formation|up regulation of tridecane synthesis|up-regulation of tridecane anabolism|up-regulation of tridecane biosynthesis|up-regulation of tridecane biosynthetic process|up-regulation of tridecane formation|up-regulation of tridecane synthesis|upregulation of tridecane anabolism|upregulation of tridecane biosynthesis|upregulation of tridecane biosynthetic process|upregulation of tridecane formation|upregulation of tridecane synthesis http://purl.obolibrary.org/obo/GO_1900886 GO:1900885 biolink:BiologicalProcess negative regulation of tridecane biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of tridecane biosynthetic process. go.json down regulation of tridecane anabolism|down regulation of tridecane biosynthesis|down regulation of tridecane biosynthetic process|down regulation of tridecane formation|down regulation of tridecane synthesis|down-regulation of tridecane anabolism|down-regulation of tridecane biosynthesis|down-regulation of tridecane biosynthetic process|down-regulation of tridecane formation|down-regulation of tridecane synthesis|downregulation of tridecane anabolism|downregulation of tridecane biosynthesis|downregulation of tridecane biosynthetic process|downregulation of tridecane formation|downregulation of tridecane synthesis|inhibition of tridecane anabolism|inhibition of tridecane biosynthesis|inhibition of tridecane biosynthetic process|inhibition of tridecane formation|inhibition of tridecane synthesis|negative regulation of tridecane anabolism|negative regulation of tridecane biosynthesis|negative regulation of tridecane formation|negative regulation of tridecane synthesis http://purl.obolibrary.org/obo/GO_1900885 GO:1900880 biolink:BiologicalProcess 18-methylnonadec-1-ene metabolic process The chemical reactions and pathways involving 18-methylnonadec-1-ene. go.json 18-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900880 GO:1900882 biolink:BiologicalProcess 17-methylnonadec-1-ene metabolic process The chemical reactions and pathways involving 17-methylnonadec-1-ene. go.json 17-methylnonadec-1-ene metabolism http://purl.obolibrary.org/obo/GO_1900882 GO:1900881 biolink:BiologicalProcess 18-methylnonadec-1-ene biosynthetic process The chemical reactions and pathways resulting in the formation of 18-methylnonadec-1-ene. go.json 18-methylnonadec-1-ene anabolism|18-methylnonadec-1-ene biosynthesis|18-methylnonadec-1-ene formation|18-methylnonadec-1-ene synthesis http://purl.obolibrary.org/obo/GO_1900881 GO:0071759 biolink:CellularComponent IgX immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0071759 GO:0071758 biolink:CellularComponent IgW immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0071758 GO:0071757 biolink:CellularComponent hexameric IgM immunoglobulin complex A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide. go.json hexameric IgM antibody http://purl.obolibrary.org/obo/GO_0071757 GO:0071756 biolink:CellularComponent pentameric IgM immunoglobulin complex A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide. go.json pentameric IgM antibody http://purl.obolibrary.org/obo/GO_0071756 GO:0071755 biolink:CellularComponent IgM B cell receptor complex An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. go.json membrane-bound IgM|surface IgM http://purl.obolibrary.org/obo/GO_0071755 GO:0071754 biolink:CellularComponent IgM immunoglobulin complex, circulating A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph. go.json IgM antibody http://purl.obolibrary.org/obo/GO_0071754 GO:0071753 biolink:CellularComponent IgM immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json http://purl.obolibrary.org/obo/GO_0071753 GO:0071752 biolink:CellularComponent secretory dimeric IgA immunoglobulin complex A dimeric form of secretory IgA immunoglobulin complex. go.json secretory dimeric IgA antibody|secretory dimeric IgA1 antibody http://purl.obolibrary.org/obo/GO_0071752 GO:0071751 biolink:CellularComponent secretory IgA immunoglobulin complex A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component. go.json sIgA antibody|sIgA1 antibody|secretory IgA antibody http://purl.obolibrary.org/obo/GO_0071751 GO:0071750 biolink:CellularComponent dimeric IgA immunoglobulin complex A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. go.json dimeric IgA antibody|dimeric IgA1 antibody http://purl.obolibrary.org/obo/GO_0071750 GO:0071781 biolink:CellularComponent endoplasmic reticulum cisternal network A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae. These are typically found close to the nucleus and are generally more prominent in secretory cells. go.json ER cisternal network http://purl.obolibrary.org/obo/GO_0071781 GO:0071780 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071780 GO:1900899 biolink:BiologicalProcess regulation of heptadecane metabolic process Any process that modulates the frequency, rate or extent of heptadecane metabolic process. go.json regulation of heptadecane metabolism http://purl.obolibrary.org/obo/GO_1900899 GO:1900898 biolink:BiologicalProcess positive regulation of heptadecane biosynthetic process Any process that activates or increases the frequency, rate or extent of heptadecane biosynthetic process. go.json activation of heptadecane anabolism|activation of heptadecane biosynthesis|activation of heptadecane biosynthetic process|activation of heptadecane formation|activation of heptadecane synthesis|positive regulation of heptadecane anabolism|positive regulation of heptadecane biosynthesis|positive regulation of heptadecane formation|positive regulation of heptadecane synthesis|up regulation of heptadecane anabolism|up regulation of heptadecane biosynthesis|up regulation of heptadecane biosynthetic process|up regulation of heptadecane formation|up regulation of heptadecane synthesis|up-regulation of heptadecane anabolism|up-regulation of heptadecane biosynthesis|up-regulation of heptadecane biosynthetic process|up-regulation of heptadecane formation|up-regulation of heptadecane synthesis|upregulation of heptadecane anabolism|upregulation of heptadecane biosynthesis|upregulation of heptadecane biosynthetic process|upregulation of heptadecane formation|upregulation of heptadecane synthesis http://purl.obolibrary.org/obo/GO_1900898 GO:1900895 biolink:BiologicalProcess positive regulation of tridecane metabolic process Any process that activates or increases the frequency, rate or extent of tridecane metabolic process. go.json activation of tridecane metabolic process|activation of tridecane metabolism|positive regulation of tridecane metabolism|up regulation of tridecane metabolic process|up regulation of tridecane metabolism|up-regulation of tridecane metabolic process|up-regulation of tridecane metabolism|upregulation of tridecane metabolic process|upregulation of tridecane metabolism http://purl.obolibrary.org/obo/GO_1900895 GO:1900894 biolink:BiologicalProcess negative regulation of tridecane metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tridecane metabolic process. go.json down regulation of tridecane metabolic process|down regulation of tridecane metabolism|down-regulation of tridecane metabolic process|down-regulation of tridecane metabolism|downregulation of tridecane metabolic process|downregulation of tridecane metabolism|inhibition of tridecane metabolic process|inhibition of tridecane metabolism|negative regulation of tridecane metabolism http://purl.obolibrary.org/obo/GO_1900894 GO:1900897 biolink:BiologicalProcess negative regulation of heptadecane biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process. go.json down regulation of heptadecane anabolism|down regulation of heptadecane biosynthesis|down regulation of heptadecane biosynthetic process|down regulation of heptadecane formation|down regulation of heptadecane synthesis|down-regulation of heptadecane anabolism|down-regulation of heptadecane biosynthesis|down-regulation of heptadecane biosynthetic process|down-regulation of heptadecane formation|down-regulation of heptadecane synthesis|downregulation of heptadecane anabolism|downregulation of heptadecane biosynthesis|downregulation of heptadecane biosynthetic process|downregulation of heptadecane formation|downregulation of heptadecane synthesis|inhibition of heptadecane anabolism|inhibition of heptadecane biosynthesis|inhibition of heptadecane biosynthetic process|inhibition of heptadecane formation|inhibition of heptadecane synthesis|negative regulation of heptadecane anabolism|negative regulation of heptadecane biosynthesis|negative regulation of heptadecane formation|negative regulation of heptadecane synthesis http://purl.obolibrary.org/obo/GO_1900897 GO:1900896 biolink:BiologicalProcess regulation of heptadecane biosynthetic process Any process that modulates the frequency, rate or extent of heptadecane biosynthetic process. go.json regulation of heptadecane anabolism|regulation of heptadecane biosynthesis|regulation of heptadecane formation|regulation of heptadecane synthesis http://purl.obolibrary.org/obo/GO_1900896 GO:1900891 biolink:BiologicalProcess negative regulation of pentadecane metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane metabolic process. go.json down regulation of pentadecane metabolic process|down regulation of pentadecane metabolism|down-regulation of pentadecane metabolic process|down-regulation of pentadecane metabolism|downregulation of pentadecane metabolic process|downregulation of pentadecane metabolism|inhibition of pentadecane metabolic process|inhibition of pentadecane metabolism|negative regulation of pentadecane metabolism http://purl.obolibrary.org/obo/GO_1900891 GO:1900890 biolink:BiologicalProcess regulation of pentadecane metabolic process Any process that modulates the frequency, rate or extent of pentadecane metabolic process. go.json regulation of pentadecane metabolism http://purl.obolibrary.org/obo/GO_1900890 GO:1900893 biolink:BiologicalProcess regulation of tridecane metabolic process Any process that modulates the frequency, rate or extent of tridecane metabolic process. go.json regulation of tridecane metabolism http://purl.obolibrary.org/obo/GO_1900893 GO:1900892 biolink:BiologicalProcess positive regulation of pentadecane metabolic process Any process that activates or increases the frequency, rate or extent of pentadecane metabolic process. go.json activation of pentadecane metabolic process|activation of pentadecane metabolism|positive regulation of pentadecane metabolism|up regulation of pentadecane metabolic process|up regulation of pentadecane metabolism|up-regulation of pentadecane metabolic process|up-regulation of pentadecane metabolism|upregulation of pentadecane metabolic process|upregulation of pentadecane metabolism http://purl.obolibrary.org/obo/GO_1900892 GO:0071789 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071789 GO:0071788 biolink:BiologicalProcess endoplasmic reticulum tubular network maintenance The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. go.json ER tubular network maintenance http://purl.obolibrary.org/obo/GO_0071788 GO:0071787 biolink:BiologicalProcess endoplasmic reticulum tubular network formation The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. go.json ER tubular network assembly|ER tubular network formation|endoplasmic reticulum tubular network assembly http://purl.obolibrary.org/obo/GO_0071787 GO:0071786 biolink:BiologicalProcess endoplasmic reticulum tubular network organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section. go.json ER tubular network organisation|ER tubular network organization|endoplasmic reticulum tubular network organisation http://purl.obolibrary.org/obo/GO_0071786 GO:0071785 biolink:BiologicalProcess endoplasmic reticulum cisternal network maintenance The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. go.json ER cisternal network maintenance http://purl.obolibrary.org/obo/GO_0071785 GO:0071784 biolink:BiologicalProcess endoplasmic reticulum cisternal network assembly The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. go.json ER cisternal network assembly|ER cisternal network formation|endoplasmic reticulum cisternal network formation http://purl.obolibrary.org/obo/GO_0071784 GO:0071783 biolink:BiologicalProcess endoplasmic reticulum cisternal network organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. go.json ER cisternal network organisation|ER cisternal network organization|endoplasmic reticulum cisternal network organisation http://purl.obolibrary.org/obo/GO_0071783 GO:0071782 biolink:CellularComponent endoplasmic reticulum tubular network A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. go.json ER tubular network http://purl.obolibrary.org/obo/GO_0071782 GO:0071770 biolink:BiologicalProcess DIM/DIP cell wall layer assembly The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall. go.json DIM cell wall layer assembly|DIM/DIP cell wall layer biogenesis|PDIM cell wall layer assembly http://purl.obolibrary.org/obo/GO_0071770 GO:0140195 biolink:BiologicalProcess positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. go.json http://purl.obolibrary.org/obo/GO_0140195 GO:0140194 biolink:BiologicalProcess negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. go.json http://purl.obolibrary.org/obo/GO_0140194 GO:0140196 biolink:BiologicalProcess positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. go.json http://purl.obolibrary.org/obo/GO_0140196 GO:0140199 biolink:BiologicalProcess negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. go.json http://purl.obolibrary.org/obo/GO_0140199 GO:0071779 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071779 GO:0071778 biolink:CellularComponent obsolete WINAC complex OBSOLETE. A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors. go.json WINAC complex True http://purl.obolibrary.org/obo/GO_0071778 GO:0071777 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071777 GO:0071776 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071776 GO:0071775 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071775 GO:0071774 biolink:BiologicalProcess response to fibroblast growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. go.json response to FGF stimulus|response to fibroblast growth factor stimulus http://purl.obolibrary.org/obo/GO_0071774 GO:0071773 biolink:BiologicalProcess cellular response to BMP stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. go.json cellular response to bone morphogenetic protein stimulus http://purl.obolibrary.org/obo/GO_0071773 GO:0140193 biolink:BiologicalProcess regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. go.json http://purl.obolibrary.org/obo/GO_0140193 GO:0071772 biolink:BiologicalProcess response to BMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. go.json response to BMP stimulus|response to bone morphogenetic protein stimulus http://purl.obolibrary.org/obo/GO_0071772 GO:0071771 biolink:MolecularActivity aldehyde decarbonylase activity Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO. go.json decarbonylase activity http://purl.obolibrary.org/obo/GO_0071771 GO:0140192 biolink:BiologicalProcess regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. go.json http://purl.obolibrary.org/obo/GO_0140192 GO:0140147 biolink:BiologicalProcess zinc ion export from vacuole The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140147 GO:0140140 biolink:BiologicalProcess mitochondrial guanine nucleotide transmembrane transport The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0140140 GO:0140142 biolink:MolecularActivity nucleocytoplasmic carrier activity Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein. go.json miRNA transporter activity|nucleocytoplasmic importin/exportin activity|pre-miRNA transporter activity http://purl.obolibrary.org/obo/GO_0140142 gocheck_do_not_annotate GO:0140141 biolink:BiologicalProcess mitochondrial potassium ion transmembrane transport The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0140141 GO:0140146 biolink:BiologicalProcess calcium ion import into vacuole The directed movement of calcium cations into the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0140146 GO:0140145 biolink:BiologicalProcess copper ion export from vacuole The directed movement of copper ions out of the vacuole across the vacuolar membrane. go.json http://purl.obolibrary.org/obo/GO_0140145 GO:0071792 biolink:BiologicalProcess bacillithiol metabolic process The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species. go.json bacillithiol metabolism http://purl.obolibrary.org/obo/GO_0071792 GO:0071791 biolink:MolecularActivity chemokine (C-C motif) ligand 5 binding Binding to chemokine (C-C motif) ligand 5. go.json CCL5 binding|RANTES binding|Regulated upon Activation, Normal T-cell Expressed, and Secreted binding http://purl.obolibrary.org/obo/GO_0071791 GO:0071790 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071790 GO:0140131 biolink:BiologicalProcess positive regulation of lymphocyte chemotaxis Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. go.json http://purl.obolibrary.org/obo/GO_0140131 GO:0140133 biolink:BiologicalProcess suppression by symbiont of host cytokine production Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. go.json negative regulation by symbiont of host cytokine production|suppression by symbiont of host cytokine secretion http://purl.obolibrary.org/obo/GO_0140133 GO:0140132 biolink:MolecularActivity iron-sulfur cluster carrier activity Binding to an iron-sulfur cluster and delivering it to an acceptor molecule. go.json http://purl.obolibrary.org/obo/GO_0140132 GO:0140135 biolink:MolecularActivity mechanosensitive monoatomic cation channel activity Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress. Reactome:R-HSA-9659380|Reactome:R-HSA-9663363 go.json mechanically-gated cation channel activity|mechanosensitive cation channel activity http://purl.obolibrary.org/obo/GO_0140135 GO:0071799 biolink:BiologicalProcess cellular response to prostaglandin D stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. go.json http://purl.obolibrary.org/obo/GO_0071799 GO:0071798 biolink:BiologicalProcess response to prostaglandin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. go.json response to prostaglandin D stimulus http://purl.obolibrary.org/obo/GO_0071798 GO:0071797 biolink:CellularComponent LUBAC complex A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex. go.json http://purl.obolibrary.org/obo/GO_0071797 GO:0071796 biolink:MolecularActivity K6-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein. go.json http://purl.obolibrary.org/obo/GO_0071796 GO:0071795 biolink:MolecularActivity K11-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein. go.json http://purl.obolibrary.org/obo/GO_0071795 GO:0071794 biolink:MolecularActivity CAP-Gly domain binding Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets. go.json http://purl.obolibrary.org/obo/GO_0071794 GO:0071793 biolink:BiologicalProcess bacillithiol biosynthetic process The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species. go.json bacillithiol anabolism|bacillithiol biosynthesis|bacillithiol formation|bacillithiol synthesis http://purl.obolibrary.org/obo/GO_0071793 GO:0140161 biolink:MolecularActivity monocarboxylate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in). go.json http://purl.obolibrary.org/obo/GO_0140161 GO:0140164 biolink:MolecularActivity Golgi transport complex binding Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family. go.json COG complex binding http://purl.obolibrary.org/obo/GO_0140164 GO:0140160 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140160 GO:0140159 biolink:BiologicalProcess borate export across plasma membrane The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region. go.json http://purl.obolibrary.org/obo/GO_0140159 GO:0140157 biolink:BiologicalProcess ammonium import across plasma membrane The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140157 GO:0032319 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032319 GO:0032318 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032318 GO:0032317 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032317 GO:0032316 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032316 GO:0032315 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032315 GO:0007359 biolink:BiologicalProcess posterior abdomen determination The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes. go.json http://purl.obolibrary.org/obo/GO_0007359 GO:0007358 biolink:BiologicalProcess obsolete establishment of central gap gene boundaries OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel. go.json True http://purl.obolibrary.org/obo/GO_0007358 GO:0032314 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032314 GO:0007357 biolink:BiologicalProcess obsolete positive regulation of central gap gene transcription OBSOLETE. The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products. go.json activation of central gap gene|activation of central gap gene transcription|stimulation of central gap gene transcription|up regulation of central gap gene transcription|up-regulation of central gap gene transcription|upregulation of central gap gene transcription True http://purl.obolibrary.org/obo/GO_0007357 GO:0046965 biolink:MolecularActivity nuclear retinoid X receptor binding Binding to a nuclear retinoid X receptor. go.json RXR binding|retinoid X receptor binding http://purl.obolibrary.org/obo/GO_0046965 GO:0007356 biolink:BiologicalProcess thorax and anterior abdomen determination Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product. go.json http://purl.obolibrary.org/obo/GO_0007356 GO:0046964 biolink:MolecularActivity 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other. Reactome:R-HSA-741449 go.json 3'-phosphoadenosine 5'-phosphosulphate transporter activity|PAPS transporter activity|adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0046964 GO:0046963 biolink:BiologicalProcess 3'-phosphoadenosine 5'-phosphosulfate transport The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 3'-phosphoadenosine 5'-phosphosulphate transport|PAPS transport|adenosine 3'-phosphate 5'-phosphosulfate transport http://purl.obolibrary.org/obo/GO_0046963 GO:0007355 biolink:BiologicalProcess anterior region determination Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product. go.json http://purl.obolibrary.org/obo/GO_0007355 GO:0046962 biolink:MolecularActivity sodium-transporting ATPase activity, rotational mechanism Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism. EC:7.2.2.1|MetaCyc:3.6.3.15-RXN|RHEA:58156|RHEA:58157 go.json ATP phosphohydrolase (Na+-transporting) activity|ATP synthase, sodium ion specific activity|Na(+)-translocating ATPase activity|Na(+)-transporting two-sector ATPase activity|Na+-translocating ATPase activity|Na+-translocating F1Fo-ATPase|Na+-transporting two-sector ATPase|sodium transporting ATPase activity, rotational mechanism|sodium-translocating F-type ATPase activity|sodium-translocating V-type ATPase activity|sodium-transporting two-sector ATPase activity|vacuolar-type Na+-ATPase|vacuolar-type Na+-translocating ATPase http://purl.obolibrary.org/obo/GO_0046962 GO:0007354 biolink:BiologicalProcess zygotic determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade. go.json http://purl.obolibrary.org/obo/GO_0007354 GO:0046961 biolink:MolecularActivity proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism. RHEA:57721 go.json ATP phosphohydrolase (H+-transporting) activity|ATP synthase activity|F(0)F(1)-ATPase activity|F(1)-ATPase activity|F(o)F(1)-ATPase activity|F0F1-ATPase|F1-ATPase|FoF1-ATPase|H+-transporting ATP synthase activity|H+-transporting ATPase activity|chloroplast ATPase activity|hydrogen ion translocating A-type ATPase activity|hydrogen ion translocating F-type ATPase activity|hydrogen ion translocating V-type ATPase activity|hydrogen ion transporting ATPase activity, rotational mechanism|hydrogen ion transporting two-sector ATPase activity|mitochondrial ATPase activity http://purl.obolibrary.org/obo/GO_0046961 GO:0007353 biolink:BiologicalProcess obsolete ventral/lateral system OBSOLETE. (Was not defined before being made obsolete). go.json ventral/lateral system True http://purl.obolibrary.org/obo/GO_0007353 GO:0046960 biolink:BiologicalProcess sensitization An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched. Wikipedia:Sensitization go.json http://purl.obolibrary.org/obo/GO_0046960 GO:0007352 biolink:BiologicalProcess zygotic specification of dorsal/ventral axis The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote. go.json zygotic determination of dorsal-ventral axis|zygotic determination of dorsal/ventral axis|zygotic determination of dorsoventral axis http://purl.obolibrary.org/obo/GO_0007352 GO:0007351 biolink:BiologicalProcess tripartite regional subdivision Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. go.json http://purl.obolibrary.org/obo/GO_0007351 GO:0071919 biolink:BiologicalProcess G-quadruplex DNA formation A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature. go.json G quadruplex DNA formation|G quartet DNA formation|G-quartet DNA formation http://purl.obolibrary.org/obo/GO_0071919 GO:0007350 biolink:BiologicalProcess blastoderm segmentation The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. go.json http://purl.obolibrary.org/obo/GO_0007350 GO:0071929 biolink:BiologicalProcess alpha-tubulin acetylation The addition of an acetyl group to the lysine 40 residue of alpha-tubulin. go.json http://purl.obolibrary.org/obo/GO_0071929 gocheck_do_not_annotate GO:0007360 biolink:BiologicalProcess obsolete positive regulation of posterior gap gene transcription OBSOLETE. The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene. go.json activation of posterior gap gene|activation of posterior gap gene transcription|knirps activation|stimulation of posterior gap gene transcription|up regulation of posterior gap gene transcription|up-regulation of posterior gap gene transcription|upregulation of posterior gap gene transcription True http://purl.obolibrary.org/obo/GO_0007360 GO:0071928 biolink:BiologicalProcess tyramine signaling pathway The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor. go.json tyramine signalling pathway http://purl.obolibrary.org/obo/GO_0071928 GO:0071927 biolink:BiologicalProcess octopamine signaling pathway The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor. go.json octopamine signalling pathway http://purl.obolibrary.org/obo/GO_0071927 GO:0071926 biolink:BiologicalProcess endocannabinoid signaling pathway The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol. go.json endocannabinoid signalling pathway http://purl.obolibrary.org/obo/GO_0071926 GO:0071925 biolink:BiologicalProcess thymic stromal lymphopoietin production The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json TSLP production http://purl.obolibrary.org/obo/GO_0071925 gocheck_do_not_annotate GO:0046969 biolink:MolecularActivity NAD-dependent histone H3K9 deacetylase activity Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. Reactome:R-HSA-9604829 go.json NAD-dependent H3-K9 histone deacetylase activity|NAD-dependent histone deacetylase activity (H3-K9 specific) http://purl.obolibrary.org/obo/GO_0046969 GO:0071924 biolink:BiologicalProcess chemokine (C-C motif) ligand 22 production The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json C-C motif chemokine 22 production|CCL-22 production|CCL22 production http://purl.obolibrary.org/obo/GO_0071924 gocheck_do_not_annotate GO:0046968 biolink:BiologicalProcess peptide antigen transport The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. go.json http://purl.obolibrary.org/obo/GO_0046968 GO:0046967 biolink:BiologicalProcess cytosol to endoplasmic reticulum transport The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell. go.json cytosol to ER transport http://purl.obolibrary.org/obo/GO_0046967 GO:0071923 biolink:BiologicalProcess negative regulation of cohesin loading Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin. go.json negative regulation of cohesin association with chromatin|negative regulation of cohesin localisation to chromatin|negative regulation of cohesin localization to chromatin http://purl.obolibrary.org/obo/GO_0071923 GO:0071922 biolink:BiologicalProcess regulation of cohesin loading Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin. go.json regulation of cohesin association with chromatin|regulation of cohesin localisation to chromatin|regulation of cohesin localization to chromatin http://purl.obolibrary.org/obo/GO_0071922 GO:0046966 biolink:MolecularActivity nuclear thyroid hormone receptor binding Binding to a nuclear thyroid hormone receptor. go.json ligand-dependent thyroid hormone receptor interactor activity|thyroid hormone receptor binding http://purl.obolibrary.org/obo/GO_0046966 GO:0071921 biolink:BiologicalProcess cohesin loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA. go.json cohesin association with chromatin|cohesin localisation to chromatin|cohesin localization to chromatin http://purl.obolibrary.org/obo/GO_0071921 GO:0032313 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032313 GO:0032312 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032312 GO:0071920 biolink:CellularComponent cleavage body A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing. go.json http://purl.obolibrary.org/obo/GO_0071920 GO:0032311 biolink:CellularComponent angiogenin-PRI complex A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis. go.json angiogenin-placental ribonuclease inhibitor complex http://purl.obolibrary.org/obo/GO_0032311 GO:0032310 biolink:BiologicalProcess prostaglandin secretion The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue. go.json prostacyclin secretion http://purl.obolibrary.org/obo/GO_0032310 GO:1900804 biolink:BiologicalProcess obsolete brevianamide F catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of brevianamide F. go.json L-prolyl-L-tryptophan anhydride breakdown|L-prolyl-L-tryptophan anhydride catabolic process|L-prolyl-L-tryptophan anhydride catabolism|L-prolyl-L-tryptophan anhydride degradation|L-tryptophyl-L-proline cyclic anhydride breakdown|L-tryptophyl-L-proline cyclic anhydride catabolic process|L-tryptophyl-L-proline cyclic anhydride catabolism|L-tryptophyl-L-proline cyclic anhydride degradation|brevianamide F breakdown|brevianamide F catabolism|brevianamide F degradation|cyclo-(Trp-Pro) breakdown|cyclo-(Trp-Pro) catabolic process|cyclo-(Trp-Pro) catabolism|cyclo-(Trp-Pro) degradation|cyclo-L-Trp-L-Pro breakdown|cyclo-L-Trp-L-Pro catabolic process|cyclo-L-Trp-L-Pro catabolism|cyclo-L-Trp-L-Pro degradation|cyclo-L-tryptophanyl-L-proline breakdown|cyclo-L-tryptophanyl-L-proline catabolic process|cyclo-L-tryptophanyl-L-proline catabolism|cyclo-L-tryptophanyl-L-proline degradation|tryptophan-proline diketopiperazine breakdown|tryptophan-proline diketopiperazine catabolic process|tryptophan-proline diketopiperazine catabolism|tryptophan-proline diketopiperazine degradation True http://purl.obolibrary.org/obo/GO_1900804 GO:0032309 biolink:BiologicalProcess icosanoid secretion The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue. go.json eicosanoid secretion http://purl.obolibrary.org/obo/GO_0032309 GO:1900803 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900803 GO:0032308 biolink:BiologicalProcess positive regulation of prostaglandin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell. go.json activation of prostaglandin secretion|positive regulation of prostacyclin secretion|stimulation of prostaglandin secretion|up regulation of prostaglandin secretion|up-regulation of prostaglandin secretion|upregulation of prostaglandin secretion http://purl.obolibrary.org/obo/GO_0032308 GO:1900806 biolink:BiologicalProcess obsolete ergot alkaloid catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ergot alkaloid. go.json ergot alkaloid breakdown|ergot alkaloid catabolism|ergot alkaloid degradation|ergot alkaloids breakdown|ergot alkaloids catabolic process|ergot alkaloids catabolism|ergot alkaloids degradation True http://purl.obolibrary.org/obo/GO_1900806 GO:1900805 biolink:BiologicalProcess brevianamide F biosynthetic process The chemical reactions and pathways resulting in the formation of brevianamide F. Brevianamide F is the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by some fungi. go.json C16H17N3O2 anabolism|C16H17N3O2 biosynthesis|C16H17N3O2 biosynthetic process|C16H17N3O2 formation|C16H17N3O2 synthesis|L-prolyl-L-tryptophan anhydride anabolism|L-prolyl-L-tryptophan anhydride biosynthesis|L-prolyl-L-tryptophan anhydride biosynthetic process|L-prolyl-L-tryptophan anhydride formation|L-prolyl-L-tryptophan anhydride synthesis|L-tryptophyl-L-proline cyclic anhydride anabolism|L-tryptophyl-L-proline cyclic anhydride biosynthesis|L-tryptophyl-L-proline cyclic anhydride biosynthetic process|L-tryptophyl-L-proline cyclic anhydride formation|L-tryptophyl-L-proline cyclic anhydride synthesis|brevianamide F anabolism|brevianamide F biosynthesis|brevianamide F formation|brevianamide F metabolic process|brevianamide F synthesis|cyclo-(Trp-Pro) anabolism|cyclo-(Trp-Pro) biosynthesis|cyclo-(Trp-Pro) biosynthetic process|cyclo-(Trp-Pro) formation|cyclo-(Trp-Pro) synthesis|cyclo-L-Trp-L-Pro anabolism|cyclo-L-Trp-L-Pro biosynthesis|cyclo-L-Trp-L-Pro biosynthetic process|cyclo-L-Trp-L-Pro formation|cyclo-L-Trp-L-Pro synthesis|cyclo-L-tryptophanyl-L-proline anabolism|cyclo-L-tryptophanyl-L-proline biosynthesis|cyclo-L-tryptophanyl-L-proline biosynthetic process|cyclo-L-tryptophanyl-L-proline formation|cyclo-L-tryptophanyl-L-proline synthesis|tryptophan-proline diketopiperazine anabolism|tryptophan-proline diketopiperazine biosynthesis|tryptophan-proline diketopiperazine biosynthetic process|tryptophan-proline diketopiperazine formation|tryptophan-proline diketopiperazine synthesis http://purl.obolibrary.org/obo/GO_1900805 GO:0032307 biolink:BiologicalProcess negative regulation of prostaglandin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell. go.json down regulation of prostaglandin secretion|down-regulation of prostaglandin secretion|downregulation of prostaglandin secretion|inhibition of prostaglandin secretion|negative regulation of prostacyclin secretion http://purl.obolibrary.org/obo/GO_0032307 GO:0032306 biolink:BiologicalProcess regulation of prostaglandin secretion Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. go.json regulation of prostacyclin secretion http://purl.obolibrary.org/obo/GO_0032306 GO:1900800 biolink:BiologicalProcess cspyrone B1 metabolic process The chemical reactions and pathways involving cspyrone B1. go.json cspyrone B1 metabolism http://purl.obolibrary.org/obo/GO_1900800 GO:0032305 biolink:BiologicalProcess positive regulation of icosanoid secretion Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell. go.json activation of icosanoid secretion|positive regulation of eicosanoid secretion|stimulation of icosanoid secretion|up regulation of icosanoid secretion|up-regulation of icosanoid secretion|upregulation of icosanoid secretion http://purl.obolibrary.org/obo/GO_0032305 GO:0032304 biolink:BiologicalProcess negative regulation of icosanoid secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell. go.json down regulation of icosanoid secretion|down-regulation of icosanoid secretion|downregulation of icosanoid secretion|inhibition of icosanoid secretion|negative regulation of eicosanoid secretion http://purl.obolibrary.org/obo/GO_0032304 GO:1900802 biolink:BiologicalProcess cspyrone B1 biosynthetic process The chemical reactions and pathways resulting in the formation of cspyrone B1. go.json cspyrone B1 anabolism|cspyrone B1 biosynthesis|cspyrone B1 formation|cspyrone B1 synthesis http://purl.obolibrary.org/obo/GO_1900802 GO:1900801 biolink:BiologicalProcess cspyrone B1 catabolic process The chemical reactions and pathways resulting in the breakdown of cspyrone B1. go.json cspyrone B1 breakdown|cspyrone B1 catabolism|cspyrone B1 degradation http://purl.obolibrary.org/obo/GO_1900801 GO:0032303 biolink:BiologicalProcess regulation of icosanoid secretion Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. go.json regulation of eicosanoid secretion http://purl.obolibrary.org/obo/GO_0032303 GO:0007369 biolink:BiologicalProcess gastrulation A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. Wikipedia:Gastrulation go.json http://purl.obolibrary.org/obo/GO_0007369 goslim_drosophila GO:0046976 biolink:MolecularActivity histone H3K27 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein. EC:2.1.1.356|Reactome:R-HSA-3240295 go.json histone H3K27 methylase activity|histone lysine N-methyltransferase activity (H3-K27 specific)|histone methylase activity (H3-K27 specific)|histone methylase activity (H3-K56 specific)|histone methyltransferase activity (H3-K27 specific)|histone-H3K27 methyltransferase activity http://purl.obolibrary.org/obo/GO_0046976 GO:0007368 biolink:BiologicalProcess determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. go.json determination of left/right asymmetry http://purl.obolibrary.org/obo/GO_0007368 GO:0046975 biolink:MolecularActivity histone H3K36 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein. go.json histone H3K36 methylase activity|histone lysine N-methyltransferase activity (H3-K36 specific)|histone methylase activity (H3-K36 specific)|histone methyltransferase activity (H3-K36 specific)|histone-H3K36 methyltransferase activity http://purl.obolibrary.org/obo/GO_0046975 GO:0007367 biolink:BiologicalProcess segment polarity determination Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products. go.json http://purl.obolibrary.org/obo/GO_0007367 GO:0046974 biolink:MolecularActivity histone H3K9 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein. Reactome:R-HSA-427336|Reactome:R-HSA-427527 go.json histone H3K9 methylase activity|histone lysine N-methyltransferase activity (H3-K9 specific)|histone methylase activity (H3-K9 specific)|histone methyltransferase activity (H3-K9 specific)|histone-H3K9 methyltransferase activity http://purl.obolibrary.org/obo/GO_0046974 GO:0007366 biolink:BiologicalProcess periodic partitioning by pair rule gene Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities. go.json http://purl.obolibrary.org/obo/GO_0007366 GO:0046973 biolink:MolecularActivity obsolete histone lysine N-methyltransferase activity (H3-K24 specific) OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein. go.json histone lysine N-methyltransferase activity (H3-K24 specific) True http://purl.obolibrary.org/obo/GO_0046973 GO:0007365 biolink:BiologicalProcess periodic partitioning The regionalization process that divides the spatial regions of an embryo into serially repeated regions. go.json http://purl.obolibrary.org/obo/GO_0007365 GO:0007364 biolink:BiologicalProcess obsolete establishment of terminal gap gene boundary OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes. go.json True http://purl.obolibrary.org/obo/GO_0007364 GO:0046972 biolink:MolecularActivity histone H4K16 acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. go.json histone acetylase activity (H4-K16 specific)|histone acetyltransferase activity (H4-K16 specific)|histone lysine acetyltransferase activity (H4-K16 specific) http://purl.obolibrary.org/obo/GO_0046972 GO:0007363 biolink:BiologicalProcess obsolete positive regulation of terminal gap gene transcription OBSOLETE. The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes. go.json activation of terminal gap gene|activation of terminal gap gene transcription|stimulation of terminal gap gene transcription|up regulation of terminal gap gene transcription|up-regulation of terminal gap gene transcription|upregulation of terminal gap gene transcription True http://purl.obolibrary.org/obo/GO_0007363 GO:0046971 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046971 GO:0071909 biolink:BiologicalProcess determination of stomach left/right asymmetry Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism. go.json http://purl.obolibrary.org/obo/GO_0071909 GO:0046970 biolink:MolecularActivity NAD-dependent histone H4K16 deacetylase activity Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. go.json NAD-dependent histone H4-K16 deacetylase activity|NAD-dependent histone deacetylase activity (H4-K16 specific) http://purl.obolibrary.org/obo/GO_0046970 GO:0007362 biolink:BiologicalProcess terminal region determination Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products. go.json http://purl.obolibrary.org/obo/GO_0007362 GO:0071908 biolink:BiologicalProcess determination of intestine left/right asymmetry Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism. go.json http://purl.obolibrary.org/obo/GO_0071908 GO:0007361 biolink:BiologicalProcess obsolete establishment of posterior gap gene boundaries OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps. go.json True http://purl.obolibrary.org/obo/GO_0007361 GO:0071918 biolink:BiologicalProcess urea transmembrane transport The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. go.json urea membrane transport http://purl.obolibrary.org/obo/GO_0071918 GO:0007371 biolink:BiologicalProcess ventral midline determination The regionalization process in which the area where the ventral midline will form is specified. go.json determination of anterior border of ventral midline|determination of posterior border of ventral midline http://purl.obolibrary.org/obo/GO_0007371 GO:0007370 biolink:BiologicalProcess ventral furrow formation Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. go.json http://purl.obolibrary.org/obo/GO_0007370 GO:0071917 biolink:MolecularActivity triose-phosphate transmembrane transporter activity Enables the transfer of a triose phosphate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0071917 GO:0071916 biolink:MolecularActivity dipeptide transmembrane transporter activity Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. go.json dipeptide transporter activity http://purl.obolibrary.org/obo/GO_0071916 GO:0071915 biolink:BiologicalProcess protein-lysine lysylation The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P). go.json protein amino acid lysylation http://purl.obolibrary.org/obo/GO_0071915 gocheck_do_not_annotate GO:0071914 biolink:CellularComponent prominosome An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known. go.json prominin-containing extracellular membrane vesicle http://purl.obolibrary.org/obo/GO_0071914 GO:0046979 biolink:MolecularActivity TAP2 binding Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein. go.json http://purl.obolibrary.org/obo/GO_0046979 GO:0071913 biolink:MolecularActivity citrate secondary active transmembrane transporter activity Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. go.json citrate carrier activity http://purl.obolibrary.org/obo/GO_0071913 GO:0046978 biolink:MolecularActivity TAP1 binding Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein. go.json http://purl.obolibrary.org/obo/GO_0046978 GO:0071912 biolink:BiologicalProcess asynchronous neurotransmitter secretion Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion. go.json http://purl.obolibrary.org/obo/GO_0071912 GO:0046977 biolink:MolecularActivity TAP binding Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. go.json http://purl.obolibrary.org/obo/GO_0046977 GO:0071911 biolink:BiologicalProcess synchronous neurotransmitter secretion Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion. go.json http://purl.obolibrary.org/obo/GO_0071911 GO:0032302 biolink:CellularComponent MutSbeta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. go.json MMR complex|MSH2/MSH3 complex http://purl.obolibrary.org/obo/GO_0032302 GO:0071910 biolink:BiologicalProcess determination of liver left/right asymmetry Determination of the asymmetric location of the liver with respect to the left and right halves of the organism. go.json http://purl.obolibrary.org/obo/GO_0071910 GO:0032301 biolink:CellularComponent MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. go.json MMR complex|MSH2/MSH6 complex http://purl.obolibrary.org/obo/GO_0032301 GO:0032300 biolink:CellularComponent mismatch repair complex Any complex formed of proteins that act in mismatch repair. go.json http://purl.obolibrary.org/obo/GO_0032300 goslim_pir GO:1900808 biolink:BiologicalProcess obsolete fumigaclavine C catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumigaclavine C. go.json fumigaclavine C breakdown|fumigaclavine C catabolism|fumigaclavine C degradation True http://purl.obolibrary.org/obo/GO_1900808 GO:1900807 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900807 GO:1900809 biolink:BiologicalProcess fumigaclavine C biosynthetic process The chemical reactions and pathways resulting in the formation of fumigaclavine C, a fungal ergot alkaloid. go.json fumigaclavine C anabolism|fumigaclavine C biosynthesis|fumigaclavine C formation|fumigaclavine C metabolic process|fumigaclavine C metabolism|fumigaclavine C synthesis http://purl.obolibrary.org/obo/GO_1900809 GO:1900815 biolink:BiologicalProcess monodictyphenone biosynthetic process The chemical reactions and pathways resulting in the formation of monodictyphenone. go.json monodictyphenone anabolism|monodictyphenone biosynthesis|monodictyphenone formation|monodictyphenone synthesis http://purl.obolibrary.org/obo/GO_1900815 GO:1900814 biolink:BiologicalProcess monodictyphenone catabolic process The chemical reactions and pathways resulting in the breakdown of monodictyphenone. go.json monodictyphenone breakdown|monodictyphenone catabolism|monodictyphenone degradation http://purl.obolibrary.org/obo/GO_1900814 GO:1900817 biolink:BiologicalProcess ochratoxin A catabolic process The chemical reactions and pathways resulting in the breakdown of ochratoxin A. go.json ochratoxin A breakdown|ochratoxin A catabolism|ochratoxin A degradation http://purl.obolibrary.org/obo/GO_1900817 GO:1900816 biolink:BiologicalProcess ochratoxin A metabolic process The chemical reactions and pathways involving ochratoxin A. go.json Ochratoxin A metabolism http://purl.obolibrary.org/obo/GO_1900816 GO:1900811 biolink:BiologicalProcess helvolic acid catabolic process The chemical reactions and pathways resulting in the breakdown of helvolic acid. go.json Fumigacin breakdown|Fumigacin catabolic process|Fumigacin catabolism|Fumigacin degradation|helvolic acid breakdown|helvolic acid catabolism|helvolic acid degradation http://purl.obolibrary.org/obo/GO_1900811 GO:0007339 biolink:BiologicalProcess binding of sperm to zona pellucida The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. go.json ZPG binding http://purl.obolibrary.org/obo/GO_0007339 GO:0007338 biolink:BiologicalProcess single fertilization The union of male and female gametes to form a zygote. go.json zygote biosynthesis|zygote formation http://purl.obolibrary.org/obo/GO_0007338 GO:1900810 biolink:BiologicalProcess helvolic acid metabolic process The chemical reactions and pathways involving helvolic acid. go.json Fumigacin metabolic process|Fumigacin metabolism|helvolic acid metabolism http://purl.obolibrary.org/obo/GO_1900810 GO:1900813 biolink:BiologicalProcess monodictyphenone metabolic process The chemical reactions and pathways involving monodictyphenone. go.json monodictyphenone metabolism http://purl.obolibrary.org/obo/GO_1900813 GO:0007337 biolink:BiologicalProcess obsolete unilateral process OBSOLETE. (Was not defined before being made obsolete). go.json unilateral process True http://purl.obolibrary.org/obo/GO_0007337 GO:1900812 biolink:BiologicalProcess helvolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of helvolic acid. go.json Fumigacin anabolism|Fumigacin biosynthesis|Fumigacin biosynthetic process|Fumigacin formation|Fumigacin synthesis|helvolic acid anabolism|helvolic acid biosynthesis|helvolic acid formation|helvolic acid synthesis http://purl.obolibrary.org/obo/GO_1900812 GO:0007336 biolink:BiologicalProcess obsolete bilateral process OBSOLETE. (Was not defined before being made obsolete). go.json bilateral process True http://purl.obolibrary.org/obo/GO_0007336 GO:0007335 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007335 GO:0046987 biolink:MolecularActivity N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine). go.json galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity http://purl.obolibrary.org/obo/GO_0046987 GO:0046986 biolink:BiologicalProcess negative regulation of hemoglobin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. go.json down regulation of hemoglobin biosynthetic process|down-regulation of hemoglobin biosynthetic process|downregulation of hemoglobin biosynthetic process|inhibition of hemoglobin biosynthetic process|negative regulation of haemoglobin biosynthesis|negative regulation of haemoglobin biosynthetic process|negative regulation of hemoglobin anabolism|negative regulation of hemoglobin biosynthesis|negative regulation of hemoglobin formation|negative regulation of hemoglobin synthesis http://purl.obolibrary.org/obo/GO_0046986 GO:0007334 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007334 GO:0046985 biolink:BiologicalProcess positive regulation of hemoglobin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. go.json activation of hemoglobin biosynthetic process|positive regulation of haemoglobin biosynthesis|positive regulation of haemoglobin biosynthetic process|positive regulation of hemoglobin anabolism|positive regulation of hemoglobin biosynthesis|positive regulation of hemoglobin formation|positive regulation of hemoglobin synthesis|stimulation of hemoglobin biosynthetic process|up regulation of hemoglobin biosynthetic process|up-regulation of hemoglobin biosynthetic process|upregulation of hemoglobin biosynthetic process http://purl.obolibrary.org/obo/GO_0046985 GO:0007333 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007333 GO:0007332 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007332 GO:0046984 biolink:BiologicalProcess regulation of hemoglobin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. go.json regulation of haemoglobin biosynthesis|regulation of haemoglobin biosynthetic process|regulation of hemoglobin anabolism|regulation of hemoglobin biosynthesis|regulation of hemoglobin formation|regulation of hemoglobin synthesis http://purl.obolibrary.org/obo/GO_0046984 GO:0007331 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007331 GO:0046983 biolink:MolecularActivity protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. go.json http://purl.obolibrary.org/obo/GO_0046983 GO:0046982 biolink:MolecularActivity protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer. go.json http://purl.obolibrary.org/obo/GO_0046982 goslim_chembl GO:0007330 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007330 GO:0046981 biolink:MolecularActivity beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids. go.json UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0046981 GO:0046980 biolink:MolecularActivity tapasin binding Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules. go.json TAP binding protein binding|TAPBP binding http://purl.obolibrary.org/obo/GO_0046980 GO:0071949 biolink:MolecularActivity FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. go.json oxidized flavin adenine dinucleotide binding|oxidized flavine-adenine dinucleotide binding http://purl.obolibrary.org/obo/GO_0071949 GO:0071948 biolink:BiologicalProcess activation-induced B cell apoptotic process B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death. go.json AICD|activated B cell apoptosis|activation-induced B cell apoptosis|activation-induced B-cell apoptosis|activation-induced cell death of B cells|activation-induced cell death of B lymphocytes|activation-induced cell death of B-cells|activation-induced cell death of B-lymphocytes|antigen-driven apoptosis http://purl.obolibrary.org/obo/GO_0071948 GO:0071947 biolink:BiologicalProcess protein deubiquitination involved in ubiquitin-dependent protein catabolic process The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism. go.json http://purl.obolibrary.org/obo/GO_0071947 gocheck_do_not_annotate GO:0071946 biolink:BiologicalProcess cis-acting DNA replication termination A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing. go.json cis acting DNA replication termination http://purl.obolibrary.org/obo/GO_0071946 GO:0046989 biolink:MolecularActivity galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids. go.json http://purl.obolibrary.org/obo/GO_0046989 GO:0071945 biolink:BiologicalProcess regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein. go.json regulation of bacterial-type flagellar cell motility by regulation of motor speed|regulation of bacterial-type flagellum cell motility by regulation of motor speed|regulation of flagellar cell motility by regulation of motor speed http://purl.obolibrary.org/obo/GO_0071945 GO:0071944 biolink:CellularComponent cell periphery The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. go.json http://purl.obolibrary.org/obo/GO_0071944 goslim_flybase_ribbon GO:0046988 biolink:MolecularActivity asioloorosomucoid beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid. go.json http://purl.obolibrary.org/obo/GO_0046988 GO:0071943 biolink:CellularComponent Myc-Max complex A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max. go.json http://purl.obolibrary.org/obo/GO_0071943 GO:0071942 biolink:CellularComponent XPC complex A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2. go.json http://purl.obolibrary.org/obo/GO_0071942 GO:0071941 biolink:BiologicalProcess nitrogen cycle metabolic process A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. Wikipedia:Nitrogen_cycle go.json http://purl.obolibrary.org/obo/GO_0071941 goslim_chembl|goslim_generic|goslim_pombe|prokaryote_subset GO:0071940 biolink:BiologicalProcess fungal-type cell wall assembly The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall. go.json fungal-type cell wall formation http://purl.obolibrary.org/obo/GO_0071940 GO:1900819 biolink:BiologicalProcess orlandin metabolic process The chemical reactions and pathways involving orlandin. go.json orlandin metabolism http://purl.obolibrary.org/obo/GO_1900819 GO:1900818 biolink:BiologicalProcess ochratoxin A biosynthetic process The chemical reactions and pathways resulting in the formation of ochratoxin A. go.json Ochratoxin A anabolism|Ochratoxin A biosynthesis|Ochratoxin A formation|Ochratoxin A synthesis http://purl.obolibrary.org/obo/GO_1900818 GO:1900826 biolink:BiologicalProcess negative regulation of membrane depolarization during cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. go.json down regulation of membrane depolarization during cardiac muscle cell action potential|down-regulation of membrane depolarization during of cardiac muscle cell action potential|downregulation of membrane depolarization during cardiac muscle cell action potential|inhibition of membrane depolarization during cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1900826 GO:0046990 biolink:MolecularActivity N-hydroxyarylamine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. EC:2.3.1.118|MetaCyc:2.3.1.118-RXN|RHEA:20277 go.json N-hydroxy-2-aminofluorene-O-acetyltransferase activity|acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity|arylhydroxamate N,O-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0046990 GO:1900825 biolink:BiologicalProcess regulation of membrane depolarization during cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. go.json http://purl.obolibrary.org/obo/GO_1900825 GO:1900828 biolink:BiologicalProcess D-tyrosine metabolic process The chemical reactions and pathways involving D-tyrosine. go.json D-tyrosine metabolism http://purl.obolibrary.org/obo/GO_1900828 GO:1900827 biolink:BiologicalProcess positive regulation of membrane depolarization during cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. go.json activation of membrane depolarization during cardiac muscle cell action potential|up regulation of membrane depolarization during cardiac muscle cell action potential|up-regulation of membrane depolarization during cardiac muscle cell action potential|upregulation of membrane depolarization during cardiac muscle cell action potential http://purl.obolibrary.org/obo/GO_1900827 GO:1900822 biolink:BiologicalProcess regulation of ergot alkaloid biosynthetic process Any process that modulates the frequency, rate or extent of ergot alkaloid biosynthetic process. go.json regulation of ergot alkaloid anabolism|regulation of ergot alkaloid biosynthesis|regulation of ergot alkaloid formation|regulation of ergot alkaloid synthesis http://purl.obolibrary.org/obo/GO_1900822 GO:1900821 biolink:BiologicalProcess orlandin biosynthetic process The chemical reactions and pathways resulting in the formation of orlandin. go.json orlandin anabolism|orlandin biosynthesis|orlandin formation|orlandin synthesis http://purl.obolibrary.org/obo/GO_1900821 GO:0007349 biolink:BiologicalProcess cellularization The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development. go.json http://purl.obolibrary.org/obo/GO_0007349 GO:1900824 biolink:BiologicalProcess positive regulation of ergot alkaloid biosynthetic process Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process. go.json activation of ergot alkaloid anabolism|activation of ergot alkaloid biosynthesis|activation of ergot alkaloid biosynthetic process|activation of ergot alkaloid formation|activation of ergot alkaloid synthesis|positive regulation of ergot alkaloid anabolism|positive regulation of ergot alkaloid biosynthesis|positive regulation of ergot alkaloid formation|positive regulation of ergot alkaloid synthesis|up regulation of ergot alkaloid anabolism|up regulation of ergot alkaloid biosynthesis|up regulation of ergot alkaloid biosynthetic process|up regulation of ergot alkaloid formation|up regulation of ergot alkaloid synthesis|up-regulation of ergot alkaloid anabolism|up-regulation of ergot alkaloid biosynthesis|up-regulation of ergot alkaloid biosynthetic process|up-regulation of ergot alkaloid formation|up-regulation of ergot alkaloid synthesis|upregulation of ergot alkaloid anabolism|upregulation of ergot alkaloid biosynthesis|upregulation of ergot alkaloid biosynthetic process|upregulation of ergot alkaloid formation|upregulation of ergot alkaloid synthesis http://purl.obolibrary.org/obo/GO_1900824 GO:0007348 biolink:BiologicalProcess regulation of syncytial blastoderm mitotic cell cycle A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle. go.json modulation of syncytial blastoderm cell cycle progression|regulation of progression through syncytial blastoderm mitotic cell cycle|regulation of syncytial blastoderm cell cycle|regulation of syncytial blastoderm cell cycle progression|syncytial blastoderm cell cycle modulation|syncytial blastoderm cell cycle regulation|syncytial blastoderm cell cycle regulator http://purl.obolibrary.org/obo/GO_0007348 GO:1900823 biolink:BiologicalProcess negative regulation of ergot alkaloid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ergot alkaloid biosynthetic process. go.json down regulation of ergot alkaloid anabolism|down regulation of ergot alkaloid biosynthesis|down regulation of ergot alkaloid biosynthetic process|down regulation of ergot alkaloid formation|down regulation of ergot alkaloid synthesis|down-regulation of ergot alkaloid anabolism|down-regulation of ergot alkaloid biosynthesis|down-regulation of ergot alkaloid biosynthetic process|down-regulation of ergot alkaloid formation|down-regulation of ergot alkaloid synthesis|downregulation of ergot alkaloid anabolism|downregulation of ergot alkaloid biosynthesis|downregulation of ergot alkaloid biosynthetic process|downregulation of ergot alkaloid formation|downregulation of ergot alkaloid synthesis|inhibition of ergot alkaloid anabolism|inhibition of ergot alkaloid biosynthesis|inhibition of ergot alkaloid biosynthetic process|inhibition of ergot alkaloid formation|inhibition of ergot alkaloid synthesis|negative regulation of ergot alkaloid anabolism|negative regulation of ergot alkaloid biosynthesis|negative regulation of ergot alkaloid formation|negative regulation of ergot alkaloid synthesis http://purl.obolibrary.org/obo/GO_1900823 GO:0007347 biolink:BiologicalProcess regulation of preblastoderm mitotic cell cycle A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle. go.json modulation of preblastoderm mitotic cell cycle progression|preblastoderm mitotic cell cycle modulation|preblastoderm mitotic cell cycle regulation|preblastoderm mitotic cell cycle regulator|regulation of preblastoderm mitotic cell cycle progression|regulation of progression through preblastoderm mitotic cell cycle http://purl.obolibrary.org/obo/GO_0007347 GO:0007346 biolink:BiologicalProcess regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle. go.json mitotic cell cycle modulation|mitotic cell cycle regulation|mitotic cell cycle regulator|modulation of mitotic cell cycle progression|regulation of mitotic cell cycle progression|regulation of progression through mitotic cell cycle http://purl.obolibrary.org/obo/GO_0007346 GO:0046998 biolink:MolecularActivity (S)-usnate reductase activity Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH. EC:1.1.1.199|KEGG_REACTION:R07345|MetaCyc:1.1.1.199-RXN|RHEA:21876 go.json L-usnic acid dehydrogenase activity|reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming) http://purl.obolibrary.org/obo/GO_0046998 GO:0007345 biolink:BiologicalProcess obsolete embryogenesis and morphogenesis OBSOLETE. Formation and development of an embryo and its organized structures. go.json embryogenesis and morphogenesis True http://purl.obolibrary.org/obo/GO_0007345 GO:0046997 biolink:MolecularActivity oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. EC:1.5.8.- go.json http://purl.obolibrary.org/obo/GO_0046997 GO:1900820 biolink:BiologicalProcess orlandin catabolic process The chemical reactions and pathways resulting in the breakdown of orlandin. go.json orlandin breakdown|orlandin catabolism|orlandin degradation http://purl.obolibrary.org/obo/GO_1900820 GO:0007344 biolink:BiologicalProcess pronuclear fusion The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome. go.json http://purl.obolibrary.org/obo/GO_0007344 GO:0046996 biolink:MolecularActivity obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated. EC:1.14.21.- go.json oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated True http://purl.obolibrary.org/obo/GO_0046996 GO:0007343 biolink:BiologicalProcess egg activation The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. Wikipedia:Egg_activation go.json http://purl.obolibrary.org/obo/GO_0007343 GO:0046995 biolink:MolecularActivity oxidoreductase activity, acting on hydrogen as donor, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound. EC:1.12.98.- go.json http://purl.obolibrary.org/obo/GO_0046995 GO:0007342 biolink:BiologicalProcess fusion of sperm to egg plasma membrane involved in single fertilization The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head. go.json sperm-oocyte fusion http://purl.obolibrary.org/obo/GO_0007342 GO:0046994 biolink:MolecularActivity oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound. EC:1.12.5.- go.json http://purl.obolibrary.org/obo/GO_0046994 GO:0007341 biolink:BiologicalProcess penetration of zona pellucida The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. go.json http://purl.obolibrary.org/obo/GO_0007341 GO:0046993 biolink:MolecularActivity oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen. EC:1.21.3.- go.json http://purl.obolibrary.org/obo/GO_0046993 GO:0046992 biolink:MolecularActivity oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y. EC:1.21.-.- go.json oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors http://purl.obolibrary.org/obo/GO_0046992 GO:0007340 biolink:BiologicalProcess acrosome reaction The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. Wikipedia:Acrosome_reaction go.json http://purl.obolibrary.org/obo/GO_0007340 GO:0046991 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046991 GO:0071939 biolink:BiologicalProcess vitamin A import into cell The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. go.json vitamin A import|vitamin A uptake http://purl.obolibrary.org/obo/GO_0071939 GO:0071938 biolink:BiologicalProcess vitamin A transport The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. go.json vitamin A uptake and transport http://purl.obolibrary.org/obo/GO_0071938 GO:0071937 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071937 GO:0071936 biolink:MolecularActivity obsolete coreceptor activity involved in Wnt signaling pathway OBSOLETE. In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway. go.json Wnt co-receptor activity|coreceptor activity involved in Wnt receptor signaling pathway|coreceptor activity involved in Wnt receptor signalling pathway|coreceptor activity involved in Wnt-activated signaling pathway True http://purl.obolibrary.org/obo/GO_0071936 GO:0071935 biolink:BiologicalProcess octopamine signaling pathway involved in response to food The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus. go.json octopamine signalling pathway involved in response to food http://purl.obolibrary.org/obo/GO_0071935 GO:0071934 biolink:BiologicalProcess thiamine transmembrane transport The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. go.json thiamin transmembrane transport|thiamine membrane transport|vitamin B1 transmembrane transport http://purl.obolibrary.org/obo/GO_0071934 GO:0046999 biolink:BiologicalProcess obsolete regulation of conjugation OBSOLETE. Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual. go.json True http://purl.obolibrary.org/obo/GO_0046999 GO:0071933 biolink:MolecularActivity Arp2/3 complex binding Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). go.json http://purl.obolibrary.org/obo/GO_0071933 GO:0071932 biolink:BiologicalProcess replication fork reversal Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved. go.json http://purl.obolibrary.org/obo/GO_0071932 GO:0071931 biolink:BiologicalProcess obsolete positive regulation of transcription involved in G1/S transition of mitotic cell cycle OBSOLETE. Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle. go.json positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0071931 GO:0071930 biolink:BiologicalProcess obsolete negative regulation of transcription involved in G1/S transition of mitotic cell cycle OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle. go.json negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle True http://purl.obolibrary.org/obo/GO_0071930 GO:1900829 biolink:BiologicalProcess D-tyrosine catabolic process The chemical reactions and pathways resulting in the breakdown of D-tyrosine. go.json D-tyrosine breakdown|D-tyrosine catabolism|D-tyrosine degradation http://purl.obolibrary.org/obo/GO_1900829 GO:1900837 biolink:BiologicalProcess regulation of fumigaclavine C biosynthetic process Any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process. go.json regulation of fumigaclavine C anabolism|regulation of fumigaclavine C biosynthesis|regulation of fumigaclavine C formation|regulation of fumigaclavine C synthesis http://purl.obolibrary.org/obo/GO_1900837 GO:1900836 biolink:BiologicalProcess positive regulation of emericellin biosynthetic process Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_1900836 GO:0007319 biolink:BiologicalProcess negative regulation of oskar mRNA translation Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein. go.json down regulation of oskar mRNA translation|down-regulation of oskar mRNA translation|downregulation of oskar mRNA translation|inhibition of oskar mRNA translation http://purl.obolibrary.org/obo/GO_0007319 GO:1900839 biolink:BiologicalProcess positive regulation of fumigaclavine C biosynthetic process Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process. go.json up regulation of fumigaclavine C biosynthetic process|up-regulation of fumigaclavine C biosynthetic process|upregulation of fumigaclavine C biosynthetic process http://purl.obolibrary.org/obo/GO_1900839 GO:1900838 biolink:BiologicalProcess negative regulation of fumigaclavine C biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process. go.json inhibition of fumigaclavine C biosynthetic process http://purl.obolibrary.org/obo/GO_1900838 GO:0007318 biolink:BiologicalProcess pole plasm protein localization Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. go.json establishment and maintenance of pole plasm protein localization|oocyte pole plasm protein localization|pole plasm protein localisation http://purl.obolibrary.org/obo/GO_0007318 GO:1900833 biolink:BiologicalProcess D-leucine biosynthetic process The chemical reactions and pathways resulting in the formation of D-leucine. go.json D-leucine anabolism|D-leucine biosynthesis|D-leucine formation|D-leucine synthesis http://purl.obolibrary.org/obo/GO_1900833 GO:0007317 biolink:BiologicalProcess regulation of pole plasm oskar mRNA localization Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. go.json regulation of oocyte pole plasm oskar mRNA localization|regulation of pole plasm oskar mRNA localisation http://purl.obolibrary.org/obo/GO_0007317 GO:1900832 biolink:BiologicalProcess D-leucine catabolic process The chemical reactions and pathways resulting in the breakdown of D-leucine. go.json D-leucine breakdown|D-leucine catabolism|D-leucine degradation http://purl.obolibrary.org/obo/GO_1900832 GO:0007316 biolink:BiologicalProcess pole plasm RNA localization Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. go.json establishment and maintenance of pole plasm RNA localization|oocyte pole plasm RNA localization|pole plasm RNA localisation http://purl.obolibrary.org/obo/GO_0007316 GO:1900835 biolink:BiologicalProcess negative regulation of emericellin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process. go.json down regulation of emericellin biosynthetic process|down-regulation of emericellin biosynthetic process|downregulation of emericellin biosynthetic process http://purl.obolibrary.org/obo/GO_1900835 GO:0007315 biolink:BiologicalProcess pole plasm assembly Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster. go.json http://purl.obolibrary.org/obo/GO_0007315 GO:1900834 biolink:BiologicalProcess regulation of emericellin biosynthetic process Any process that modulates the frequency, rate or extent of emericellin biosynthetic process. go.json regulation of Variecoxanthone B anabolism|regulation of Variecoxanthone B biosynthesis|regulation of Variecoxanthone B biosynthetic process|regulation of Variecoxanthone B formation|regulation of Variecoxanthone B synthesis|regulation of emericellin anabolism|regulation of emericellin biosynthesis|regulation of emericellin formation|regulation of emericellin synthesis http://purl.obolibrary.org/obo/GO_1900834 GO:0007314 biolink:BiologicalProcess oocyte anterior/posterior axis specification Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster. go.json oocyte anterior/posterior axis determination http://purl.obolibrary.org/obo/GO_0007314 GO:0007313 biolink:BiologicalProcess maternal specification of dorsal/ventral axis, oocyte, soma encoded Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster. go.json maternal determination of dorsal/ventral axis, oocyte, soma encoded|maternal specification of dorsal-ventral axis, oocyte, soma encoded|maternal specification of dorsoventral axis, oocyte, soma encoded http://purl.obolibrary.org/obo/GO_0007313 GO:0007312 biolink:BiologicalProcess oocyte nucleus migration involved in oocyte dorsal/ventral axis specification The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. go.json establishment of localization of oocyte nucleus during oocyte axis determination|establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification|establishment of oocyte nucleus localization during oocyte axis determination|establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification|establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination|establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification|establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification|nucleus positioning in oocyte during oocyte axis determination|oocyte axis determination, establishment of localization of nucleus|oocyte axis determination, establishment of oocyte nucleus localization|oocyte axis determination, establishment of position of nucleus|oocyte axis determination, oocyte nuclear migration|oocyte axis determination, oocyte nucleus migration|oocyte axis determination, positioning of nucleus|oocyte nuclear migration during oocyte axis determination|oocyte nucleus migration during oocyte axis determination|oocyte nucleus migration during oocyte axis specification|oocyte nucleus positioning during oocyte axis determination http://purl.obolibrary.org/obo/GO_0007312 GO:0007311 biolink:BiologicalProcess maternal specification of dorsal/ventral axis, oocyte, germ-line encoded Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster. go.json maternal determination of dorsal/ventral axis, oocyte, germ-line encoded|maternal specification of dorsal-ventral axis, oocyte, germ-line encoded|maternal specification of dorsoventral axis, oocyte, germ-line encoded http://purl.obolibrary.org/obo/GO_0007311 GO:1900831 biolink:BiologicalProcess D-leucine metabolic process The chemical reactions and pathways involving D-leucine. go.json D-leucine metabolism http://purl.obolibrary.org/obo/GO_1900831 GO:1900830 biolink:BiologicalProcess obsolete D-tyrosine biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of D-tyrosine. go.json D-tyrosine anabolism|D-tyrosine biosynthesis|D-tyrosine formation|D-tyrosine synthesis True http://purl.obolibrary.org/obo/GO_1900830 GO:0007310 biolink:BiologicalProcess oocyte dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. go.json oocyte dorsal-ventral axis specification|oocyte dorsal/ventral axis determination|oocyte dorsoventral axis specification http://purl.obolibrary.org/obo/GO_0007310 GO:0071969 biolink:BiologicalProcess fungal-type cell wall (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of fungi. go.json fungal-type cell wall 1,3-beta-D-glucan metabolic process|fungal-type cell wall 1,3-beta-glucan metabolism|fungal-type cell wall beta-1,3 glucan metabolic process|fungal-type cell wall beta-1,3 glucan metabolism http://purl.obolibrary.org/obo/GO_0071969 GO:0071968 biolink:MolecularActivity lipid A-core heptosyltransferase activity Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+. MetaCyc:RXN0-5127|RHEA:30019 go.json http://purl.obolibrary.org/obo/GO_0071968 GO:0071967 biolink:MolecularActivity lipopolysaccharide core heptosyltransferase activity Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+. MetaCyc:RXN0-5122|RHEA:29923 go.json LPS core heptosyltransferase activity http://purl.obolibrary.org/obo/GO_0071967 GO:0071966 biolink:BiologicalProcess fungal-type cell wall polysaccharide metabolic process The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall. go.json http://purl.obolibrary.org/obo/GO_0071966 GO:0071965 biolink:BiologicalProcess multicellular organismal locomotion Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another. go.json http://purl.obolibrary.org/obo/GO_0071965 GO:0071964 biolink:BiologicalProcess establishment of cell polarity regulating cell shape Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell. go.json http://purl.obolibrary.org/obo/GO_0071964 GO:0071963 biolink:BiologicalProcess establishment or maintenance of cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell. go.json http://purl.obolibrary.org/obo/GO_0071963 GO:0071962 biolink:BiologicalProcess mitotic sister chromatid cohesion, centromeric The cell cycle process in which centromeres of sister chromatids are joined during mitosis. go.json centromeric mitotic sister chromatin cohesion|mitotic sister chromatid cohesion at centromere|sister chromatid cohesion at centromere at mitosis http://purl.obolibrary.org/obo/GO_0071962 GO:0071961 biolink:BiologicalProcess mitotic sister chromatid cohesion, arms The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis. go.json mitotic sister chromatid cohesion along arms|sister chromatid cohesion along arms at mitosis http://purl.obolibrary.org/obo/GO_0071961 GO:0071960 biolink:BiologicalProcess maintenance of mitotic sister chromatid cohesion, centromeric The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. go.json maintenance of centromeric mitotic sister chromatin cohesion|maintenance of mitotic sister chromatin cohesion at centromere|maintenance of sister chromatin cohesion at centromere at mitosis http://purl.obolibrary.org/obo/GO_0071960 GO:1900848 biolink:BiologicalProcess positive regulation of naphtho-gamma-pyrone biosynthetic process Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process. go.json activation of naphtho-gamma-pyrone biosynthetic process|up regulation of naphtho-gamma-pyrone biosynthetic process|up-regulation of naphtho-gamma-pyrone biosynthetic process|upregulation of naphtho-gamma-pyrone biosynthetic process http://purl.obolibrary.org/obo/GO_1900848 GO:1900847 biolink:BiologicalProcess negative regulation of naphtho-gamma-pyrone biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process. go.json down regulation of naphtho-gamma-pyrone biosynthetic process|down-regulation of naphtho-gamma-pyrone biosynthetic process|downregulation of naphtho-gamma-pyrone biosynthetic process|inhibition of naphtho-gamma-pyrone biosynthetic process http://purl.obolibrary.org/obo/GO_1900847 GO:0007329 biolink:BiologicalProcess obsolete positive regulation of transcription from RNA polymerase II promoter by pheromones OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter. go.json activation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from Pol II promoter by pheromones|stimulation of transcription from RNA polymerase II promoter by pheromones|up regulation of transcription from RNA polymerase II promoter by pheromones|up-regulation of transcription from RNA polymerase II promoter by pheromones|upregulation of transcription from RNA polymerase II promoter by pheromones True http://purl.obolibrary.org/obo/GO_0007329 GO:1900849 biolink:BiologicalProcess regulation of pseurotin A biosynthetic process Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process. go.json regulation of Pseurotin anabolism|regulation of Pseurotin biosynthesis|regulation of Pseurotin biosynthetic process|regulation of Pseurotin formation|regulation of Pseurotin synthesis|regulation of pseurotin A anabolism|regulation of pseurotin A biosynthesis|regulation of pseurotin A formation|regulation of pseurotin A synthesis http://purl.obolibrary.org/obo/GO_1900849 GO:1900844 biolink:BiologicalProcess negative regulation of monodictyphenone biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of monodictyphenone biosynthetic process. go.json down regulation of monodictyphenone biosynthetic process|down-regulation of monodictyphenone biosynthetic process|downregulation of monodictyphenone biosynthetic process http://purl.obolibrary.org/obo/GO_1900844 GO:0007328 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007328 GO:1900843 biolink:BiologicalProcess regulation of monodictyphenone biosynthetic process Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process. go.json regulation of monodictyphenone anabolism|regulation of monodictyphenone biosynthesis|regulation of monodictyphenone formation|regulation of monodictyphenone synthesis http://purl.obolibrary.org/obo/GO_1900843 GO:0007327 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007327 GO:1900846 biolink:BiologicalProcess regulation of naphtho-gamma-pyrone biosynthetic process Any process that modulates the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process. go.json regulation of naphtho-gamma-pyrone anabolism|regulation of naphtho-gamma-pyrone biosynthesis|regulation of naphtho-gamma-pyrone formation|regulation of naphtho-gamma-pyrone synthesis|regulation of naphtho-gamma-pyrones anabolism|regulation of naphtho-gamma-pyrones biosynthesis|regulation of naphtho-gamma-pyrones biosynthetic process|regulation of naphtho-gamma-pyrones formation|regulation of naphtho-gamma-pyrones synthesis http://purl.obolibrary.org/obo/GO_1900846 GO:0007326 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007326 GO:1900845 biolink:BiologicalProcess positive regulation of monodictyphenone biosynthetic process Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process. go.json upregulation of monodictyphenone biosynthetic process http://purl.obolibrary.org/obo/GO_1900845 GO:0007325 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007325 GO:1900840 biolink:BiologicalProcess regulation of helvolic acid biosynthetic process Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_1900840 GO:0007324 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007324 GO:0007323 biolink:BiologicalProcess peptide pheromone maturation The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae. go.json pheromone processing http://purl.obolibrary.org/obo/GO_0007323 GO:1900842 biolink:BiologicalProcess positive regulation of helvolic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process. go.json up regulation of helvolic acid biosynthetic process|up-regulation of helvolic acid biosynthetic process|upregulation of helvolic acid biosynthetic process http://purl.obolibrary.org/obo/GO_1900842 GO:0007322 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007322 GO:1900841 biolink:BiologicalProcess negative regulation of helvolic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process. go.json down regulation of helvolic acid biosynthetic process|down-regulation of helvolic acid biosynthetic process|downregulation of helvolic acid biosynthetic process http://purl.obolibrary.org/obo/GO_1900841 GO:0007321 biolink:BiologicalProcess sperm displacement The physical displacement of sperm stored from previous mating encounters. go.json http://purl.obolibrary.org/obo/GO_0007321 GO:0007320 biolink:BiologicalProcess insemination The introduction of semen or sperm into the genital tract of a female. Wikipedia:Insemination go.json http://purl.obolibrary.org/obo/GO_0007320 GO:0071959 biolink:BiologicalProcess maintenance of mitotic sister chromatid cohesion, arms The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. go.json maintenance of mitotic sister chromatin cohesion along arms|maintenance of sister chromatin cohesion along arms at mitosis http://purl.obolibrary.org/obo/GO_0071959 GO:0071958 biolink:CellularComponent new mitotic spindle pole body The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize. go.json new SPB http://purl.obolibrary.org/obo/GO_0071958 GO:0071957 biolink:CellularComponent old mitotic spindle pole body The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis. go.json old SPB http://purl.obolibrary.org/obo/GO_0071957 GO:0071956 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071956 GO:0071955 biolink:BiologicalProcess recycling endosome to Golgi transport The directed movement of substances from recycling endosomes to the Golgi. go.json http://purl.obolibrary.org/obo/GO_0071955 GO:0071954 biolink:BiologicalProcess chemokine (C-C motif) ligand 11 production The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. go.json C-C motif chemokine 11 production|CCL-11 production|CCL11 production|eotaxin production|eotaxin-1 production http://purl.obolibrary.org/obo/GO_0071954 gocheck_do_not_annotate GO:0071953 biolink:CellularComponent elastic fiber An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. go.json elastic fibre|elastin fiber http://purl.obolibrary.org/obo/GO_0071953 GO:0071952 biolink:BiologicalProcess conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA. go.json http://purl.obolibrary.org/obo/GO_0071952 GO:0071951 biolink:BiologicalProcess conversion of methionyl-tRNA to N-formyl-methionyl-tRNA The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). go.json http://purl.obolibrary.org/obo/GO_0071951 GO:0071950 biolink:MolecularActivity FADH2 binding Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. go.json reduced flavin adenine dinucleotide binding|reduced flavine-adenine dinucleotide binding http://purl.obolibrary.org/obo/GO_0071950 GO:1900859 biolink:BiologicalProcess obsolete negative regulation of brevianamide F biosynthetic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of brevianamide F biosynthetic process. go.json down regulation of brevianamide F biosynthetic process|down-regulation of brevianamide F biosynthetic process|downregulation of brevianamide F biosynthetic process True http://purl.obolibrary.org/obo/GO_1900859 GO:1900858 biolink:BiologicalProcess obsolete regulation of brevianamide F biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of brevianamide F biosynthetic process. go.json regulation of brevianamide F anabolism|regulation of brevianamide F biosynthesis|regulation of brevianamide F formation|regulation of brevianamide F synthesis True http://purl.obolibrary.org/obo/GO_1900858 GO:1900855 biolink:BiologicalProcess obsolete regulation of fumitremorgin B biosynthetic process OBSOLETE. Any process that modulates the frequency, rate or extent of fumitremorgin B biosynthetic process. go.json regulation of Lanosulin anabolism|regulation of Lanosulin biosynthesis|regulation of Lanosulin biosynthetic process|regulation of Lanosulin formation|regulation of Lanosulin synthesis|regulation of fumitremorgin B anabolism|regulation of fumitremorgin B biosynthesis|regulation of fumitremorgin B formation|regulation of fumitremorgin B synthesis True http://purl.obolibrary.org/obo/GO_1900855 GO:1900854 biolink:BiologicalProcess positive regulation of terrequinone A biosynthetic process Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process. go.json regulation of terrequinone A biosynthetic process|up regulation of terrequinone A biosynthetic process|up-regulation of terrequinone A biosynthetic process|upregulation of terrequinone A biosynthetic process http://purl.obolibrary.org/obo/GO_1900854 GO:1900857 biolink:BiologicalProcess obsolete positive regulation of fumitremorgin B biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of fumitremorgin B biosynthetic process. go.json up regulation of fumitremorgin B biosynthetic process|up-regulation of fumitremorgin B biosynthetic process|upregulation of fumitremorgin B biosynthetic process True http://purl.obolibrary.org/obo/GO_1900857 GO:1900856 biolink:BiologicalProcess obsolete negative regulation of fumitremorgin B biosynthetic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of fumitremorgin B biosynthetic process. go.json down regulation of fumitremorgin B biosynthetic process|down-regulation of fumitremorgin B biosynthetic process|downregulation of fumitremorgin B biosynthetic process True http://purl.obolibrary.org/obo/GO_1900856 GO:1900851 biolink:BiologicalProcess positive regulation of pseurotin A biosynthetic process Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process. go.json up regulation of pseurotin A biosynthetic process|up-regulation of pseurotin A biosynthetic process|upregulation of pseurotin A biosynthetic process http://purl.obolibrary.org/obo/GO_1900851 GO:1900850 biolink:BiologicalProcess negative regulation of pseurotin A biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process. go.json down regulation of pseurotin A biosynthetic process|down-regulation of pseurotin A biosynthetic process|downregulation of pseurotin A biosynthetic process http://purl.obolibrary.org/obo/GO_1900850 GO:1900853 biolink:BiologicalProcess obsolete negative regulation of terrequinone A biosynthetic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of terrequinone A biosynthetic process. go.json down regulation of terrequinone A biosynthetic process|down-regulation of terrequinone A biosynthetic process|downregulation of terrequinone A biosynthetic process True http://purl.obolibrary.org/obo/GO_1900853 GO:1900852 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900852 GO:0071989 biolink:BiologicalProcess establishment of protein localization to spindle pole body The directed movement of a protein to a specific location at the spindle pole body. go.json establishment of protein localisation to spindle pole body http://purl.obolibrary.org/obo/GO_0071989 GO:0071988 biolink:BiologicalProcess protein localization to spindle pole body A process in which a protein is transported to, or maintained at, the spindle pole body. go.json protein localisation to spindle pole body http://purl.obolibrary.org/obo/GO_0071988 GO:0071987 biolink:MolecularActivity WD40-repeat domain binding Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. go.json WD domain binding|beta-transducin repeat domain binding http://purl.obolibrary.org/obo/GO_0071987 GO:0071986 biolink:CellularComponent Ragulator complex A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). go.json EGO complex|EGO-GSE complex|GSE complex|GTPase-containing complex for Gap1p sorting in the endosome|MAPKSP1/ROBLD3/C11orf59 complex|Rag GEF http://purl.obolibrary.org/obo/GO_0071986 GO:0071985 biolink:BiologicalProcess multivesicular body sorting pathway A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. go.json http://purl.obolibrary.org/obo/GO_0071985 GO:0071984 biolink:BiologicalProcess maintenance of reproductive diapause The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. go.json http://purl.obolibrary.org/obo/GO_0071984 GO:0071983 biolink:BiologicalProcess exit from reproductive diapause The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. go.json http://purl.obolibrary.org/obo/GO_0071983 GO:0071982 biolink:BiologicalProcess maintenance of diapause The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. go.json http://purl.obolibrary.org/obo/GO_0071982 GO:0071981 biolink:BiologicalProcess exit from diapause The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. go.json http://purl.obolibrary.org/obo/GO_0071981 GO:0071980 biolink:BiologicalProcess cell surface adhesin-mediated gliding motility Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins. go.json http://purl.obolibrary.org/obo/GO_0071980 GO:1900869 biolink:BiologicalProcess tatiopterin metabolic process The chemical reactions and pathways involving tatiopterin. go.json tatiopterin metabolism http://purl.obolibrary.org/obo/GO_1900869 GO:0007309 biolink:BiologicalProcess oocyte axis specification The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster. go.json oocyte axis determination http://purl.obolibrary.org/obo/GO_0007309 GO:0007308 biolink:BiologicalProcess oocyte construction The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. go.json oocyte arrangement http://purl.obolibrary.org/obo/GO_0007308 GO:0007307 biolink:BiologicalProcess eggshell chorion gene amplification Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster. go.json http://purl.obolibrary.org/obo/GO_0007307 GO:0007306 biolink:BiologicalProcess egg chorion assembly Construction of the chorion portion of the egg, which is a protective, noncellular membrane that surrounds the eggs of various animals including insects and fish. go.json eggshell chorion formation|insect chorion formation http://purl.obolibrary.org/obo/GO_0007306 GO:1900866 biolink:BiologicalProcess glycolate transport The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_1900866 GO:1900865 biolink:BiologicalProcess chloroplast RNA modification Any RNA modification that takes place in chloroplast. go.json RNA editing in chloroplast http://purl.obolibrary.org/obo/GO_1900865 GO:0007305 biolink:BiologicalProcess vitelline membrane formation involved in chorion-containing eggshell formation Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster. go.json vitelline membrane formation in chorion-containing eggshell http://purl.obolibrary.org/obo/GO_0007305 GO:1900868 biolink:BiologicalProcess sarcinapterin biosynthetic process The chemical reactions and pathways resulting in the formation of sarcinapterin. go.json sarcinapterin anabolism|sarcinapterin biosynthesis|sarcinapterin formation|sarcinapterin synthesis http://purl.obolibrary.org/obo/GO_1900868 GO:0007304 biolink:BiologicalProcess chorion-containing eggshell formation The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster. go.json eggshell formation http://purl.obolibrary.org/obo/GO_0007304 GO:0007303 biolink:BiologicalProcess cytoplasmic transport, nurse cell to oocyte The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte. go.json http://purl.obolibrary.org/obo/GO_0007303 GO:1900867 biolink:BiologicalProcess sarcinapterin metabolic process The chemical reactions and pathways involving sarcinapterin. go.json sarcinapterin metabolism http://purl.obolibrary.org/obo/GO_1900867 GO:1900862 biolink:BiologicalProcess negative regulation of cordyol C biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of cordyol C biosynthetic process. go.json down regulation of cordyol C biosynthetic process|down-regulation of cordyol C biosynthetic process|downregulation of cordyol C biosynthetic process http://purl.obolibrary.org/obo/GO_1900862 GO:0007302 biolink:BiologicalProcess nurse cell nucleus anchoring Attachment of the nurse cell nucleus to the plasma membrane. go.json http://purl.obolibrary.org/obo/GO_0007302 GO:1900861 biolink:BiologicalProcess regulation of cordyol C biosynthetic process Any process that modulates the frequency, rate or extent of cordyol C biosynthetic process. go.json http://purl.obolibrary.org/obo/GO_1900861 GO:0007301 biolink:BiologicalProcess female germline ring canal formation Assembly of the intercellular bridges that connect the germ-line cells of a female cyst. go.json nurse cell ring canal formation|ovarian ring canal formation http://purl.obolibrary.org/obo/GO_0007301 GO:1900864 biolink:BiologicalProcess mitochondrial RNA modification Any RNA modification that takes place in mitochondrion. go.json mitochondrial RNA editing http://purl.obolibrary.org/obo/GO_1900864 GO:0007300 biolink:BiologicalProcess ovarian nurse cell to oocyte transport Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster. go.json nurse cell to oocyte transport http://purl.obolibrary.org/obo/GO_0007300 GO:1900863 biolink:BiologicalProcess positive regulation of cordyol C biosynthetic process Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process. go.json activation of cordyol C biosynthetic process|up regulation of cordyol C biosynthetic process|up-regulation of cordyol C biosynthetic process|upregulation of cordyol C biosynthetic process http://purl.obolibrary.org/obo/GO_1900863 GO:1900860 biolink:BiologicalProcess obsolete positive regulation of brevianamide F biosynthetic process OBSOLETE. Any process that activates or increases the frequency, rate or extent of brevianamide F biosynthetic process. go.json up regulation of brevianamide F biosynthetic process|up-regulation of brevianamide F biosynthetic process|upregulation of brevianamide F biosynthetic process True http://purl.obolibrary.org/obo/GO_1900860 GO:0071979 biolink:BiologicalProcess cytoskeleton-mediated cell swimming Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium. go.json cytoskeleton-mediated swimming motility http://purl.obolibrary.org/obo/GO_0071979 GO:0071978 biolink:BiologicalProcess bacterial-type flagellum-dependent swarming motility Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. go.json bacterial-type flagellar swarming motility|bacterial-type flagellum-mediated cell swarming http://purl.obolibrary.org/obo/GO_0071978 GO:0071977 biolink:BiologicalProcess bacterial-type flagellum-dependent swimming motility Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium. go.json bacterial-type flagellar swimming motility|bacterial-type flagellum-mediated cell swimming http://purl.obolibrary.org/obo/GO_0071977 GO:0071976 biolink:BiologicalProcess cell gliding Cell motility that results in the smooth movement of a cell along a solid surface. go.json cell gliding motility http://purl.obolibrary.org/obo/GO_0071976 GO:0071975 biolink:BiologicalProcess cell swimming Cell motility that results in the smooth movement of a cell through a liquid medium. go.json cell swimming motility http://purl.obolibrary.org/obo/GO_0071975 GO:0071974 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071974 GO:0071973 biolink:BiologicalProcess bacterial-type flagellum-dependent cell motility Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. go.json bacterial-type flagellar cell motility|flagellin-based flagellar cell motility http://purl.obolibrary.org/obo/GO_0071973 goslim_metagenomics GO:0071972 biolink:MolecularActivity peptidoglycan L,D-transpeptidase activity Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. MetaCyc:RXN-11349 go.json http://purl.obolibrary.org/obo/GO_0071972 GO:0071971 biolink:BiologicalProcess extracellular exosome assembly The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. go.json extracellular vesicular exosome assembly http://purl.obolibrary.org/obo/GO_0071971 GO:0071970 biolink:BiologicalProcess fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls. go.json fungal-type cell wall 1,3-beta-D-glucan biosynthetic process|fungal-type cell wall 1,3-beta-glucan anabolism|fungal-type cell wall 1,3-beta-glucan biosynthesis|fungal-type cell wall 1,3-beta-glucan formation|fungal-type cell wall 1,3-beta-glucan synthesis|fungal-type cell wall beta-1,3-glucan anabolism|fungal-type cell wall beta-1,3-glucan biosynthesis|fungal-type cell wall beta-1,3-glucan biosynthetic process|fungal-type cell wall beta-1,3-glucan formation|fungal-type cell wall beta-1,3-glucan synthesis http://purl.obolibrary.org/obo/GO_0071970 GO:0032393 biolink:MolecularActivity MHC class I receptor activity Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. go.json T cell receptor activity|alpha-beta T cell receptor activity|gamma-delta T cell receptor activity http://purl.obolibrary.org/obo/GO_0032393 GO:0032392 biolink:BiologicalProcess DNA geometric change The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. go.json http://purl.obolibrary.org/obo/GO_0032392 goslim_pir GO:0032391 biolink:CellularComponent photoreceptor connecting cilium The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone. go.json photoreceptor cilium http://purl.obolibrary.org/obo/GO_0032391 GO:0032390 biolink:CellularComponent MutLbeta complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1. go.json MLH1/PMS1 complex|MMR complex http://purl.obolibrary.org/obo/GO_0032390 GO:0032399 biolink:MolecularActivity HECT domain binding Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein. go.json http://purl.obolibrary.org/obo/GO_0032399 GO:0032398 biolink:CellularComponent MHC class Ib protein complex A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. go.json http://purl.obolibrary.org/obo/GO_0032398 GO:0032397 biolink:MolecularActivity activating MHC class I receptor activity Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0032397 GO:0032396 biolink:MolecularActivity inhibitory MHC class I receptor activity Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. go.json http://purl.obolibrary.org/obo/GO_0032396 GO:0032395 biolink:MolecularActivity MHC class II receptor activity Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. go.json T cell receptor activity|alpha-beta T cell receptor activity|gamma-delta T cell receptor activity http://purl.obolibrary.org/obo/GO_0032395 GO:0032394 biolink:MolecularActivity MHC class Ib receptor activity Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. go.json T cell receptor activity|alpha-beta T cell receptor activity|gamma-delta T cell receptor activity http://purl.obolibrary.org/obo/GO_0032394 GO:0032382 biolink:BiologicalProcess positive regulation of intracellular sterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells. go.json activation of intracellular sterol transport|stimulation of intracellular sterol transport|up regulation of intracellular sterol transport|up-regulation of intracellular sterol transport|upregulation of intracellular sterol transport http://purl.obolibrary.org/obo/GO_0032382 GO:0032381 biolink:BiologicalProcess negative regulation of intracellular sterol transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells. go.json down regulation of intracellular sterol transport|down-regulation of intracellular sterol transport|downregulation of intracellular sterol transport|inhibition of intracellular sterol transport http://purl.obolibrary.org/obo/GO_0032381 GO:0032380 biolink:BiologicalProcess regulation of intracellular sterol transport Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells. go.json http://purl.obolibrary.org/obo/GO_0032380 GO:0032389 biolink:CellularComponent MutLalpha complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. go.json MLH1/PMS2 complex|MMR complex|MutL-alpha complex http://purl.obolibrary.org/obo/GO_0032389 GO:0032388 biolink:BiologicalProcess positive regulation of intracellular transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. go.json activation of intracellular transport|stimulation of intracellular transport|up regulation of intracellular transport|up-regulation of intracellular transport|upregulation of intracellular transport http://purl.obolibrary.org/obo/GO_0032388 GO:0032387 biolink:BiologicalProcess negative regulation of intracellular transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. go.json down regulation of intracellular transport|down-regulation of intracellular transport|downregulation of intracellular transport|inhibition of intracellular transport http://purl.obolibrary.org/obo/GO_0032387 GO:0032386 biolink:BiologicalProcess regulation of intracellular transport Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. go.json http://purl.obolibrary.org/obo/GO_0032386 GO:0032385 biolink:BiologicalProcess positive regulation of intracellular cholesterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells. go.json activation of intracellular cholesterol transport|stimulation of intracellular cholesterol transport|up regulation of intracellular cholesterol transport|up-regulation of intracellular cholesterol transport|upregulation of intracellular cholesterol transport http://purl.obolibrary.org/obo/GO_0032385 GO:0032384 biolink:BiologicalProcess negative regulation of intracellular cholesterol transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells. go.json down regulation of intracellular cholesterol transport|down-regulation of intracellular cholesterol transport|downregulation of intracellular cholesterol transport|inhibition of intracellular cholesterol transport http://purl.obolibrary.org/obo/GO_0032384 GO:0032383 biolink:BiologicalProcess regulation of intracellular cholesterol transport Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells. go.json http://purl.obolibrary.org/obo/GO_0032383 GO:0046907 biolink:BiologicalProcess intracellular transport The directed movement of substances within a cell. go.json single organism intracellular transport|single-organism intracellular transport http://purl.obolibrary.org/obo/GO_0046907 GO:0032371 biolink:BiologicalProcess regulation of sterol transport Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032371 GO:0032370 biolink:BiologicalProcess positive regulation of lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of lipid transport|stimulation of lipid transport|up regulation of lipid transport|up-regulation of lipid transport|upregulation of lipid transport http://purl.obolibrary.org/obo/GO_0032370 GO:0046906 biolink:MolecularActivity tetrapyrrole binding Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. go.json porphyrin binding http://purl.obolibrary.org/obo/GO_0046906 goslim_metagenomics|goslim_pir GO:0046905 biolink:MolecularActivity 15-cis-phytoene synthase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate. RHEA:34479 go.json phytoene synthase activity http://purl.obolibrary.org/obo/GO_0046905 GO:0046904 biolink:MolecularActivity calcium oxalate binding Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi. go.json http://purl.obolibrary.org/obo/GO_0046904 GO:0046903 biolink:BiologicalProcess secretion The controlled release of a substance by a cell or a tissue. go.json http://purl.obolibrary.org/obo/GO_0046903 goslim_pir GO:0046902 biolink:BiologicalProcess regulation of mitochondrial membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. go.json regulation of mitochondrial envelope permeability|regulation of transport across mitochondrial membrane http://purl.obolibrary.org/obo/GO_0046902 GO:0046901 biolink:BiologicalProcess tetrahydrofolylpolyglutamate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. go.json THF polyglutamylation|folic acid-containing compound polyglutamylation|tetrahydrofolate polyglutamylation|tetrahydrofolyl-[Glu](n) biosynthesis|tetrahydrofolyl-[Glu](n) biosynthetic process|tetrahydrofolylpolyglutamate anabolism|tetrahydrofolylpolyglutamate biosynthesis|tetrahydrofolylpolyglutamate formation|tetrahydrofolylpolyglutamate synthesis http://purl.obolibrary.org/obo/GO_0046901 GO:0046900 biolink:BiologicalProcess tetrahydrofolylpolyglutamate metabolic process The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. go.json tetrahydrofolyl-[Glu](n) metabolic process|tetrahydrofolyl-[Glu](n) metabolism|tetrahydrofolylpolyglutamate metabolism http://purl.obolibrary.org/obo/GO_0046900 GO:0032379 biolink:BiologicalProcess positive regulation of intracellular lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. go.json activation of intracellular lipid transport|stimulation of intracellular lipid transport|up regulation of intracellular lipid transport|up-regulation of intracellular lipid transport|upregulation of intracellular lipid transport http://purl.obolibrary.org/obo/GO_0032379 GO:0032378 biolink:BiologicalProcess negative regulation of intracellular lipid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. go.json down regulation of intracellular lipid transport|down-regulation of intracellular lipid transport|downregulation of intracellular lipid transport|inhibition of intracellular lipid transport http://purl.obolibrary.org/obo/GO_0032378 GO:0032377 biolink:BiologicalProcess regulation of intracellular lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. go.json http://purl.obolibrary.org/obo/GO_0032377 GO:0032376 biolink:BiologicalProcess positive regulation of cholesterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of cholesterol transport|stimulation of cholesterol transport|up regulation of cholesterol transport|up-regulation of cholesterol transport|upregulation of cholesterol transport http://purl.obolibrary.org/obo/GO_0032376 GO:0032375 biolink:BiologicalProcess negative regulation of cholesterol transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of cholesterol transport|down-regulation of cholesterol transport|downregulation of cholesterol transport|inhibition of cholesterol transport http://purl.obolibrary.org/obo/GO_0032375 GO:0032374 biolink:BiologicalProcess regulation of cholesterol transport Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032374 GO:0032373 biolink:BiologicalProcess positive regulation of sterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json activation of sterol transport|stimulation of sterol transport|up regulation of sterol transport|up-regulation of sterol transport|upregulation of sterol transport http://purl.obolibrary.org/obo/GO_0032373 GO:0046909 biolink:BiologicalProcess obsolete intermembrane transport OBSOLETE. The directed movement of substances between any membrane of a cell, including the plasma membrane and its regions. go.json True http://purl.obolibrary.org/obo/GO_0046909 GO:0046908 biolink:BiologicalProcess obsolete negative regulation of crystal formation OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine. go.json negative regulation of crystal formation|negative regulation of mineralization True http://purl.obolibrary.org/obo/GO_0046908 GO:0032372 biolink:BiologicalProcess negative regulation of sterol transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of sterol transport|down-regulation of sterol transport|downregulation of sterol transport|inhibition of sterol transport http://purl.obolibrary.org/obo/GO_0032372 GO:0032369 biolink:BiologicalProcess negative regulation of lipid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json down regulation of lipid transport|down-regulation of lipid transport|downregulation of lipid transport|inhibition of lipid transport http://purl.obolibrary.org/obo/GO_0032369 GO:0046910 biolink:MolecularActivity pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase. go.json http://purl.obolibrary.org/obo/GO_0046910 GO:0046918 biolink:BiologicalProcess N-terminal peptidyl-glycine N-palmitoylation The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine. RESID:AA0339 go.json http://purl.obolibrary.org/obo/GO_0046918 gocheck_do_not_annotate GO:0032360 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032360 GO:0046917 biolink:MolecularActivity triphosphoribosyl-dephospho-CoA synthase activity Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. EC:2.4.2.52|MetaCyc:2.7.8.25-RXN|RHEA:15117 go.json 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity|ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity|ATP:dephospho-CoA 5-triphosphoribosyl transferase activity|CitG activity http://purl.obolibrary.org/obo/GO_0046917 GO:0046916 biolink:BiologicalProcess obsolete intracellular transition metal ion homeostasis OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of transition metal ions within a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. go.json cellular transition metal ion homeostasis True http://purl.obolibrary.org/obo/GO_0046916 GO:0046915 biolink:MolecularActivity transition metal ion transmembrane transporter activity Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. go.json http://purl.obolibrary.org/obo/GO_0046915 GO:0046914 biolink:MolecularActivity transition metal ion binding Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. go.json http://purl.obolibrary.org/obo/GO_0046914 GO:0046913 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046913 GO:0046912 biolink:MolecularActivity acyltransferase activity, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. EC:2.3.3.- go.json acyltransferase, acyl groups converted into alkyl on transfer|transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer http://purl.obolibrary.org/obo/GO_0046912 GO:0046911 biolink:MolecularActivity metal chelating activity The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. go.json heavy metal chelation|metal chelation http://purl.obolibrary.org/obo/GO_0046911 GO:0032368 biolink:BiologicalProcess regulation of lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032368 GO:0032367 biolink:BiologicalProcess intracellular cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells. go.json http://purl.obolibrary.org/obo/GO_0032367 GO:0032366 biolink:BiologicalProcess intracellular sterol transport The directed movement of sterols within cells. go.json http://purl.obolibrary.org/obo/GO_0032366 GO:0032365 biolink:BiologicalProcess intracellular lipid transport The directed movement of lipids within cells. go.json http://purl.obolibrary.org/obo/GO_0032365 GO:0032364 biolink:BiologicalProcess intracellular oxygen homeostasis A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. go.json cellular oxygen homeostasis|oxygen homeostasis http://purl.obolibrary.org/obo/GO_0032364 GO:0032363 biolink:BiologicalProcess FMN catabolic process The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. go.json http://purl.obolibrary.org/obo/GO_0032363 GO:0032362 biolink:BiologicalProcess obsolete FAD catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide. go.json FAD breakdown|FAD catabolism|FAD degradation|oxidized flavin adenine dinucleotide catabolic process True http://purl.obolibrary.org/obo/GO_0032362 GO:0032361 biolink:BiologicalProcess pyridoxal phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. go.json http://purl.obolibrary.org/obo/GO_0032361 GO:0046919 biolink:MolecularActivity pyruvyltransferase activity Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another. go.json http://purl.obolibrary.org/obo/GO_0046919 GO:0032359 biolink:BiologicalProcess provirus excision The molecular events that lead to the excision of a viral genome from the host genome. go.json prophage excision http://purl.obolibrary.org/obo/GO_0032359 GO:0032358 biolink:MolecularActivity oxidized pyrimidine DNA binding Binding to a DNA region containing an oxidized pyrimidine residue. go.json oxidised pyrimidine DNA binding|oxidized pyrimidine base DNA binding|oxidized pyrimidine nucleobase DNA binding http://purl.obolibrary.org/obo/GO_0032358 GO:0046921 biolink:MolecularActivity alpha-(1->6)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. go.json alpha(1,6)-fucosyltransferase activity|alpha-(1,6)-fucosyltransferase activity|alpha-1,6-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0046921 GO:0046920 biolink:MolecularActivity alpha-(1->3)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. Reactome:R-HSA-9603984|Reactome:R-HSA-9605609|Reactome:R-HSA-9605644|Reactome:R-HSA-9605682 go.json alpha(1,3)-fucosyltransferase activity|alpha-(1,3)-fucosyltransferase activity|alpha-1,3-fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0046920 GO:0007399 biolink:BiologicalProcess nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. go.json pan-neural process http://purl.obolibrary.org/obo/GO_0007399 goslim_drosophila GO:0007398 biolink:BiologicalProcess ectoderm development The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. go.json http://purl.obolibrary.org/obo/GO_0007398 GO:0007397 biolink:BiologicalProcess obsolete histogenesis and organogenesis OBSOLETE. The generation of organized tissues or of whole organs. go.json histogenesis and organogenesis True http://purl.obolibrary.org/obo/GO_0007397 GO:0007396 biolink:BiologicalProcess suture of dorsal opening Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole. go.json http://purl.obolibrary.org/obo/GO_0007396 GO:0007395 biolink:BiologicalProcess dorsal closure, spreading of leading edge cells Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa. go.json http://purl.obolibrary.org/obo/GO_0007395 GO:0007394 biolink:BiologicalProcess dorsal closure, elongation of leading edge cells The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis. go.json http://purl.obolibrary.org/obo/GO_0007394 GO:0046929 biolink:BiologicalProcess negative regulation of neurotransmitter secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. go.json conotoxin activity|down regulation of neurotransmitter secretion|down-regulation of neurotransmitter secretion|downregulation of neurotransmitter secretion|inhibition of neurotransmitter secretion http://purl.obolibrary.org/obo/GO_0046929 GO:0046928 biolink:BiologicalProcess regulation of neurotransmitter secretion Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. go.json http://purl.obolibrary.org/obo/GO_0046928 GO:0046927 biolink:BiologicalProcess peptidyl-threonine racemization The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine. go.json http://purl.obolibrary.org/obo/GO_0046927 gocheck_do_not_annotate GO:0046926 biolink:BiologicalProcess peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine. RESID:AA0342 go.json http://purl.obolibrary.org/obo/GO_0046926 gocheck_do_not_annotate GO:0046925 biolink:BiologicalProcess peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine. RESID:AA0341 go.json http://purl.obolibrary.org/obo/GO_0046925 gocheck_do_not_annotate GO:0046924 biolink:BiologicalProcess peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine. RESID:AA0340 go.json http://purl.obolibrary.org/obo/GO_0046924 gocheck_do_not_annotate OIO:inSubset biolink:OntologyClass in_subset go.json http://www.geneontology.org/formats/oboInOwl#inSubset GO:0046923 biolink:MolecularActivity ER retention sequence binding Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. go.json endoplasmic reticulum retention sequence binding http://purl.obolibrary.org/obo/GO_0046923 GO:0046922 biolink:MolecularActivity peptide-O-fucosyltransferase activity Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. EC:2.4.1.221|MetaCyc:2.4.1.221-RXN|Reactome:R-HSA-1912349|Reactome:R-HSA-5173192 go.json GDP-L-fucose:polypeptide fucosyltransferase activity|GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity|GDP-fucose protein O-fucosyltransferase activity|GDP-fucose:polypeptide fucosyltransferase activity http://purl.obolibrary.org/obo/GO_0046922 GO:0032357 biolink:MolecularActivity oxidized purine DNA binding Binding to a DNA region containing an oxidized purine residue. go.json oxidised purine DNA binding|oxidized purine base DNA binding|oxidized purine nucleobase DNA binding http://purl.obolibrary.org/obo/GO_0032357 GO:0032356 biolink:MolecularActivity oxidized DNA binding Binding to a DNA region containing an oxidized residue. go.json oxidised DNA binding http://purl.obolibrary.org/obo/GO_0032356 GO:0032355 biolink:BiologicalProcess response to estradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. go.json response to E2 stimulus|response to estradiol stimulus http://purl.obolibrary.org/obo/GO_0032355 GO:0032354 biolink:BiologicalProcess response to follicle-stimulating hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. go.json response to FSH stimulus|response to follicle stimulating hormone stimulus|response to follicle-stimulating hormone stimulus http://purl.obolibrary.org/obo/GO_0032354 GO:0032353 biolink:BiologicalProcess negative regulation of hormone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. go.json down regulation of hormone biosynthetic process|down-regulation of hormone biosynthetic process|downregulation of hormone biosynthetic process|inhibition of hormone biosynthetic process http://purl.obolibrary.org/obo/GO_0032353 GO:0032352 biolink:BiologicalProcess positive regulation of hormone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. go.json activation of hormone metabolic process|positive regulation of hormone metabolism|stimulation of hormone metabolic process|up regulation of hormone metabolic process|up-regulation of hormone metabolic process|upregulation of hormone metabolic process http://purl.obolibrary.org/obo/GO_0032352 GO:0032351 biolink:BiologicalProcess negative regulation of hormone metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. go.json down regulation of hormone metabolic process|down-regulation of hormone metabolic process|downregulation of hormone metabolic process|inhibition of hormone metabolic process|negative regulation of hormone metabolism http://purl.obolibrary.org/obo/GO_0032351 GO:0032350 biolink:BiologicalProcess regulation of hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. go.json regulation of hormone metabolism http://purl.obolibrary.org/obo/GO_0032350 GO:0032349 biolink:BiologicalProcess positive regulation of aldosterone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. go.json activation of aldosterone biosynthetic process|stimulation of aldosterone biosynthetic process|up regulation of aldosterone biosynthetic process|up-regulation of aldosterone biosynthetic process|upregulation of aldosterone biosynthetic process http://purl.obolibrary.org/obo/GO_0032349 GO:0032348 biolink:BiologicalProcess negative regulation of aldosterone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. go.json down regulation of aldosterone biosynthetic process|down-regulation of aldosterone biosynthetic process|downregulation of aldosterone biosynthetic process|inhibition of aldosterone biosynthetic process http://purl.obolibrary.org/obo/GO_0032348 GO:0032347 biolink:BiologicalProcess regulation of aldosterone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. go.json http://purl.obolibrary.org/obo/GO_0032347 GO:0046932 biolink:MolecularActivity sodium-transporting ATP synthase activity, rotational mechanism Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism. EC:7.2.2.1|MetaCyc:3.6.3.15-RXN|RHEA:58156|RHEA:58158|TC:3.A.2.1.2 go.json sodium-translocating F-type ATPase activity|sodium-transporting two-sector ATPase activity http://purl.obolibrary.org/obo/GO_0046932 GO:0046931 biolink:BiologicalProcess pore complex assembly The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. go.json pore biosynthesis|pore complex biogenesis|pore formation|pore-forming toxin activity http://purl.obolibrary.org/obo/GO_0046931 GO:0046930 biolink:CellularComponent pore complex A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. go.json channel-forming toxin activity|pore|pore-forming toxin activity http://purl.obolibrary.org/obo/GO_0046930 GO:0046939 biolink:BiologicalProcess obsolete nucleotide phosphorylation OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. go.json True http://purl.obolibrary.org/obo/GO_0046939 GO:0046938 biolink:BiologicalProcess phytochelatin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. go.json cadystin biosynthetic process|phytochelatin anabolism|phytochelatin biosynthesis|phytochelatin formation|phytochelatin synthesis http://purl.obolibrary.org/obo/GO_0046938 GO:0046937 biolink:BiologicalProcess phytochelatin metabolic process The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. go.json cadystin metabolic process|cadystin metabolism|phytochelatin metabolism http://purl.obolibrary.org/obo/GO_0046937 GO:0046936 biolink:MolecularActivity 2'-deoxyadenosine deaminase activity Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3. EC:3.5.4.4|MetaCyc:ADDALT-RXN|RHEA:28190 go.json deoxyadenosine deaminase reaction http://purl.obolibrary.org/obo/GO_0046936 GO:0046935 biolink:MolecularActivity 1-phosphatidylinositol-3-kinase regulator activity Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. go.json 1-phosphatidylinositol 3-kinase regulator activity|phosphatidylinositol 3-kinase, class I, regulator activity http://purl.obolibrary.org/obo/GO_0046935 GO:0046934 biolink:MolecularActivity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+. EC:2.7.1.153|KEGG_REACTION:R04545|MetaCyc:2.7.1.153-RXN|RHEA:21292|Reactome:R-HSA-1226014|Reactome:R-HSA-1250370|Reactome:R-HSA-1250462|Reactome:R-HSA-1306957|Reactome:R-HSA-1306979|Reactome:R-HSA-1676048|Reactome:R-HSA-177939|Reactome:R-HSA-1839091|Reactome:R-HSA-1839107|Reactome:R-HSA-186800|Reactome:R-HSA-198266|Reactome:R-HSA-201510|Reactome:R-HSA-202365|Reactome:R-HSA-2029271|Reactome:R-HSA-2076220|Reactome:R-HSA-2316434|Reactome:R-HSA-2394007|Reactome:R-HSA-2424480|Reactome:R-HSA-2730870|Reactome:R-HSA-389158|Reactome:R-HSA-392300|Reactome:R-HSA-437162|Reactome:R-HSA-5218819|Reactome:R-HSA-5637801|Reactome:R-HSA-5654690|Reactome:R-HSA-5654692|Reactome:R-HSA-5654697|Reactome:R-HSA-5654701|Reactome:R-HSA-5654705|Reactome:R-HSA-5654709|Reactome:R-HSA-5654714|Reactome:R-HSA-5654717|Reactome:R-HSA-5655235|Reactome:R-HSA-5655289|Reactome:R-HSA-5655290|Reactome:R-HSA-5655323|Reactome:R-HSA-8852019|Reactome:R-HSA-9021627|Reactome:R-HSA-9603445|Reactome:R-HSA-9664664|Reactome:R-HSA-9664940|Reactome:R-HSA-9665407|Reactome:R-HSA-9672162|Reactome:R-HSA-9672177|Reactome:R-HSA-9712084 go.json phosphatidylinositol 3-kinase activity, class I|phosphatidylinositol 3-kinase activity, class II|phosphatidylinositol 3-kinase, class I, catalyst activity|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|type I phosphoinositide 3-kinase activity http://purl.obolibrary.org/obo/GO_0046934 GO:0046933 biolink:MolecularActivity proton-transporting ATP synthase activity, rotational mechanism Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out). EC:7.1.2.2|MetaCyc:ATPSYN-RXN|RHEA:57720|Reactome:R-HSA-164832|TC:3.A.2.1.1 go.json H+-transporting ATP synthase activity|hydrogen ion transporting ATP synthase activity, rotational mechanism http://purl.obolibrary.org/obo/GO_0046933 GO:0032346 biolink:BiologicalProcess positive regulation of aldosterone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. go.json activation of aldosterone metabolic process|positive regulation of aldosterone metabolism|stimulation of aldosterone metabolic process|up regulation of aldosterone metabolic process|up-regulation of aldosterone metabolic process|upregulation of aldosterone metabolic process http://purl.obolibrary.org/obo/GO_0032346 GO:0032345 biolink:BiologicalProcess negative regulation of aldosterone metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. go.json down regulation of aldosterone metabolic process|down-regulation of aldosterone metabolic process|downregulation of aldosterone metabolic process|inhibition of aldosterone metabolic process|negative regulation of aldosterone metabolism http://purl.obolibrary.org/obo/GO_0032345 GO:0032344 biolink:BiologicalProcess regulation of aldosterone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. go.json regulation of aldosterone metabolism http://purl.obolibrary.org/obo/GO_0032344 GO:0032343 biolink:BiologicalProcess aldosterone catabolic process The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. go.json http://purl.obolibrary.org/obo/GO_0032343 GO:0032342 biolink:BiologicalProcess aldosterone biosynthetic process The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. go.json http://purl.obolibrary.org/obo/GO_0032342 GO:0032341 biolink:BiologicalProcess aldosterone metabolic process The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. go.json aldosterone metabolism http://purl.obolibrary.org/obo/GO_0032341 GO:0032340 biolink:BiologicalProcess positive regulation of inhibin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell. go.json activation of inhibin secretion|stimulation of inhibin secretion|up regulation of inhibin secretion|up-regulation of inhibin secretion|upregulation of inhibin secretion http://purl.obolibrary.org/obo/GO_0032340 GO:0032339 biolink:BiologicalProcess negative regulation of inhibin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell. go.json down regulation of inhibin secretion|down-regulation of inhibin secretion|downregulation of inhibin secretion|inhibition of inhibin secretion http://purl.obolibrary.org/obo/GO_0032339 GO:0032338 biolink:BiologicalProcess regulation of inhibin secretion Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell. go.json http://purl.obolibrary.org/obo/GO_0032338 GO:0032337 biolink:BiologicalProcess positive regulation of activin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell. go.json activation of activin secretion|stimulation of activin secretion|up regulation of activin secretion|up-regulation of activin secretion|upregulation of activin secretion http://purl.obolibrary.org/obo/GO_0032337 GO:0032336 biolink:BiologicalProcess negative regulation of activin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell. go.json down regulation of activin secretion|down-regulation of activin secretion|downregulation of activin secretion|inhibition of activin secretion http://purl.obolibrary.org/obo/GO_0032336 GO:0046943 biolink:MolecularActivity carboxylic acid transmembrane transporter activity Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). Reactome:R-HSA-390347 go.json http://purl.obolibrary.org/obo/GO_0046943 GO:0007379 biolink:BiologicalProcess segment specification The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. go.json http://purl.obolibrary.org/obo/GO_0007379 GO:0007378 biolink:BiologicalProcess amnioserosa formation Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift. go.json http://purl.obolibrary.org/obo/GO_0007378 GO:0046942 biolink:BiologicalProcess carboxylic acid transport The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). go.json http://purl.obolibrary.org/obo/GO_0046942 GO:0007377 biolink:BiologicalProcess germ-band extension Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further. go.json http://purl.obolibrary.org/obo/GO_0007377 GO:0046941 biolink:MolecularActivity azetidine-2-carboxylic acid acetyltransferase activity Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid. go.json http://purl.obolibrary.org/obo/GO_0046941 GO:0046940 biolink:BiologicalProcess nucleoside monophosphate phosphorylation The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. go.json http://purl.obolibrary.org/obo/GO_0046940 GO:0007376 biolink:BiologicalProcess cephalic furrow formation Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome. go.json http://purl.obolibrary.org/obo/GO_0007376 GO:0007375 biolink:BiologicalProcess anterior midgut invagination Internalization of the anterior midgut into the interior of the embryo. go.json http://purl.obolibrary.org/obo/GO_0007375 GO:0007374 biolink:BiologicalProcess posterior midgut invagination Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior. go.json http://purl.obolibrary.org/obo/GO_0007374 GO:0007373 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007373 GO:0007372 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0007372 GO:0071907 biolink:BiologicalProcess determination of digestive tract left/right asymmetry Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed. go.json determination of gut left/right asymmetry|determination of left/right asymmetry of the digestive tract http://purl.obolibrary.org/obo/GO_0071907 GO:0007382 biolink:BiologicalProcess specification of segmental identity, maxillary segment The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0007382 GO:0007381 biolink:BiologicalProcess specification of segmental identity, labial segment The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0007381 GO:0071906 biolink:MolecularActivity CRD domain binding Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins. go.json context dependent regulatory domain binding http://purl.obolibrary.org/obo/GO_0071906 GO:0007380 biolink:BiologicalProcess specification of segmental identity, head The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0007380 GO:0071905 biolink:BiologicalProcess protein N-linked glucosylation via asparagine A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue. RESID:AA0421 go.json protein amino acid N-linked glucosylation via asparagine http://purl.obolibrary.org/obo/GO_0071905 gocheck_do_not_annotate GO:0046949 biolink:BiologicalProcess fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. go.json fatty acyl CoA biosynthetic process|fatty-acyl-CoA anabolism|fatty-acyl-CoA biosynthesis|fatty-acyl-CoA formation|fatty-acyl-CoA synthesis http://purl.obolibrary.org/obo/GO_0046949 GO:0071904 biolink:BiologicalProcess protein N-linked N-acetylgalactosaminylation via asparagine A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue. RESID:AA0420 go.json protein amino acid N-linked N-acetylgalactosaminylation via asparagine http://purl.obolibrary.org/obo/GO_0071904 gocheck_do_not_annotate GO:0046948 biolink:BiologicalProcess hydroxylysine catabolic process The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. go.json hydroxylysine breakdown|hydroxylysine catabolism|hydroxylysine degradation http://purl.obolibrary.org/obo/GO_0046948 GO:0071903 biolink:BiologicalProcess protein N-linked N-acetylglucosaminylation via asparagine A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue. RESID:AA0151 go.json protein amino acid N-linked N-acetylglucosaminylation via asparagine http://purl.obolibrary.org/obo/GO_0071903 gocheck_do_not_annotate GO:0046947 biolink:BiologicalProcess hydroxylysine biosynthetic process The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. go.json hydroxylysine anabolism|hydroxylysine biosynthesis|hydroxylysine formation|hydroxylysine synthesis http://purl.obolibrary.org/obo/GO_0046947 GO:0071902 biolink:BiologicalProcess positive regulation of protein serine/threonine kinase activity Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0071902 gocheck_do_not_annotate GO:0046946 biolink:BiologicalProcess hydroxylysine metabolic process The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases. go.json hydroxylysine metabolism http://purl.obolibrary.org/obo/GO_0046946 GO:0071901 biolink:BiologicalProcess negative regulation of protein serine/threonine kinase activity Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0071901 gocheck_do_not_annotate GO:0046945 biolink:BiologicalProcess N-terminal peptidyl-alanine N-carbamoylation The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine. RESID:AA0343 go.json N-terminal peptidyl-alanine N-carbamylation http://purl.obolibrary.org/obo/GO_0046945 gocheck_do_not_annotate GO:0071900 biolink:BiologicalProcess regulation of protein serine/threonine kinase activity Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. go.json http://purl.obolibrary.org/obo/GO_0071900 gocheck_do_not_annotate GO:0046944 biolink:BiologicalProcess protein carbamoylation The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2. go.json protein amino acid carbamoylation http://purl.obolibrary.org/obo/GO_0046944 gocheck_do_not_annotate GO:0032335 biolink:BiologicalProcess regulation of activin secretion Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell. go.json http://purl.obolibrary.org/obo/GO_0032335 GO:0032334 biolink:BiologicalProcess inhibin secretion The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. go.json http://purl.obolibrary.org/obo/GO_0032334 GO:0032333 biolink:BiologicalProcess activin secretion The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. go.json http://purl.obolibrary.org/obo/GO_0032333 GO:0032332 biolink:BiologicalProcess positive regulation of chondrocyte differentiation Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. go.json activation of chondrocyte differentiation|stimulation of chondrocyte differentiation|up regulation of chondrocyte differentiation|up-regulation of chondrocyte differentiation|upregulation of chondrocyte differentiation http://purl.obolibrary.org/obo/GO_0032332 GO:0032331 biolink:BiologicalProcess negative regulation of chondrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. go.json down regulation of chondrocyte differentiation|down-regulation of chondrocyte differentiation|downregulation of chondrocyte differentiation|inhibition of chondrocyte differentiation http://purl.obolibrary.org/obo/GO_0032331 GO:0032330 biolink:BiologicalProcess regulation of chondrocyte differentiation Any process that modulates the frequency, rate or extent of chondrocyte differentiation. go.json http://purl.obolibrary.org/obo/GO_0032330 GO:0032329 biolink:BiologicalProcess serine transport The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json serine import http://purl.obolibrary.org/obo/GO_0032329 GO:0032328 biolink:BiologicalProcess alanine transport The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json http://purl.obolibrary.org/obo/GO_0032328 GO:0032327 biolink:BiologicalProcess W-molybdopterin cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. go.json Moco catabolic process|Moco catabolism|W-molybdopterin cofactor breakdown|W-molybdopterin cofactor catabolism|W-molybdopterin cofactor degradation http://purl.obolibrary.org/obo/GO_0032327 GO:0032326 biolink:BiologicalProcess Mo-molybdopterin cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. go.json Mo-molybdopterin cofactor breakdown|Mo-molybdopterin cofactor catabolism|Mo-molybdopterin cofactor degradation|Moco catabolic process|Moco catabolism http://purl.obolibrary.org/obo/GO_0032326 GO:0032325 biolink:BiologicalProcess molybdopterin cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. go.json http://purl.obolibrary.org/obo/GO_0032325 GO:0046954 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046954 GO:0007389 biolink:BiologicalProcess pattern specification process Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. go.json pattern biosynthesis|pattern formation http://purl.obolibrary.org/obo/GO_0007389 goslim_drosophila GO:0046953 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046953 GO:0007388 biolink:BiologicalProcess posterior compartment specification The process involved in the specification of cell identity in the posterior compartments of the segmented embryo. go.json http://purl.obolibrary.org/obo/GO_0007388 GO:0046952 biolink:BiologicalProcess ketone body catabolic process The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA. MetaCyc:PWY66-368|Reactome:R-HSA-77108 go.json ketolysis|ketone body breakdown|ketone body catabolism|ketone body degradation|utilization of ketone bodies http://purl.obolibrary.org/obo/GO_0046952 GO:0046951 biolink:BiologicalProcess ketone body biosynthetic process The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. go.json ketone body anabolism|ketone body biosynthesis|ketone body formation|ketone body synthesis http://purl.obolibrary.org/obo/GO_0046951 GO:0007387 biolink:BiologicalProcess anterior compartment pattern formation The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo. go.json anterior compartment pattern specification http://purl.obolibrary.org/obo/GO_0007387 GO:0046950 biolink:BiologicalProcess cellular ketone body metabolic process The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism. go.json cellular ketone body metabolism http://purl.obolibrary.org/obo/GO_0046950 goslim_pir GO:0007386 biolink:BiologicalProcess compartment pattern specification The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation. go.json compartment specification http://purl.obolibrary.org/obo/GO_0007386 GO:0007385 biolink:BiologicalProcess specification of segmental identity, abdomen The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0007385 GO:0007384 biolink:BiologicalProcess specification of segmental identity, thorax The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0007384 GO:0007383 biolink:BiologicalProcess specification of segmental identity, antennal segment The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. go.json http://purl.obolibrary.org/obo/GO_0007383 GO:0007393 biolink:BiologicalProcess dorsal closure, leading edge cell fate determination The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. go.json http://purl.obolibrary.org/obo/GO_0007393 GO:0007392 biolink:BiologicalProcess initiation of dorsal closure Events that occur at the start of dorsal closure. go.json http://purl.obolibrary.org/obo/GO_0007392 GO:0007391 biolink:BiologicalProcess dorsal closure The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. go.json http://purl.obolibrary.org/obo/GO_0007391 GO:0007390 biolink:BiologicalProcess germ-band shortening The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo. go.json germ-band retraction http://purl.obolibrary.org/obo/GO_0007390 GO:0046959 biolink:BiologicalProcess habituation A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented. Wikipedia:Habituation go.json http://purl.obolibrary.org/obo/GO_0046959 GO:0046958 biolink:BiologicalProcess nonassociative learning A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment. go.json unconditional response http://purl.obolibrary.org/obo/GO_0046958 GO:0046957 biolink:BiologicalProcess negative phototaxis The directed movement of a cell or organism away from a source of light. go.json negative phototactic behavior|negative phototactic behaviour|negative taxis in response to light http://purl.obolibrary.org/obo/GO_0046957 GO:0046956 biolink:BiologicalProcess positive phototaxis The directed movement of a cell or organism towards a source of light. go.json positive phototactic behavior|positive phototactic behaviour|positive taxis in response to light http://purl.obolibrary.org/obo/GO_0046956 GO:0046955 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0046955 GO:0032324 biolink:BiologicalProcess molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. MetaCyc:Molybdenum-Cofactor-Biosynthesis go.json molybdopterin cofactor anabolism|molybdopterin cofactor biosynthesis|molybdopterin cofactor formation|molybdopterin cofactor synthesis http://purl.obolibrary.org/obo/GO_0032324 GO:0032323 biolink:BiologicalProcess lipoate catabolic process The chemical reactions and pathways resulting in the breakdown of lipoate. go.json lipoic acid breakdown|lipoic acid catabolism|lipoic acid degradation http://purl.obolibrary.org/obo/GO_0032323 GO:0032322 biolink:BiologicalProcess ubiquinone catabolic process The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme. go.json ubiquinone breakdown|ubiquinone catabolism|ubiquinone degradation http://purl.obolibrary.org/obo/GO_0032322 GO:0032321 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032321 GO:0032320 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0032320 GO:0140007 biolink:CellularComponent KICSTOR complex A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2. go.json http://purl.obolibrary.org/obo/GO_0140007 GO:0140009 biolink:BiologicalProcess L-aspartate import across plasma membrane The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. go.json http://purl.obolibrary.org/obo/GO_0140009 GO:0032294 biolink:BiologicalProcess peripheral nervous system non-myelinated axon ensheathment The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons. go.json ensheathment of non-myelinated axons in peripheral nervous system http://purl.obolibrary.org/obo/GO_0032294 GO:0032293 biolink:BiologicalProcess non-myelinated axon ensheathment in central nervous system The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system. go.json ensheathment of non-myelinated axons in central nervous system http://purl.obolibrary.org/obo/GO_0032293 GO:0032292 biolink:BiologicalProcess peripheral nervous system axon ensheathment The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. go.json ensheathment of axons in peripheral nervous system http://purl.obolibrary.org/obo/GO_0032292 GO:0032291 biolink:BiologicalProcess axon ensheathment in central nervous system The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. go.json ensheathment of axons in central nervous system http://purl.obolibrary.org/obo/GO_0032291 GO:0032290 biolink:BiologicalProcess peripheral nervous system myelin formation The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system. go.json myelin formation in peripheral nervous system|peripheral nervous system myelin sheath formation http://purl.obolibrary.org/obo/GO_0032290 GO:0032299 biolink:CellularComponent ribonuclease H2 complex A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. go.json RNase H2 complex http://purl.obolibrary.org/obo/GO_0032299 GO:0032298 biolink:BiologicalProcess positive regulation of DNA-templated DNA replication initiation Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication. go.json activation of DNA replication initiation|negative regulation of DNA replication initiation|positive regulation of DNA-dependent DNA replication initiation|stimulation of DNA replication initiation|up regulation of DNA replication initiation|up-regulation of DNA replication initiation|upregulation of DNA replication initiation http://purl.obolibrary.org/obo/GO_0032298 GO:0032297 biolink:BiologicalProcess negative regulation of DNA-templated DNA replication initiation Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. go.json down regulation of DNA replication initiation|down-regulation of DNA replication initiation|downregulation of DNA replication initiation|inhibition of DNA replication initiation|negative regulation of DNA replication initiation|negative regulation of DNA-dependent DNA replication initiation http://purl.obolibrary.org/obo/GO_0032297 GO:0032296 biolink:MolecularActivity double-stranded RNA-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. go.json double-stranded RNA-specific RNase activity|dsRNA-specific RNase activity|dsRNA-specific ribonuclease activity http://purl.obolibrary.org/obo/GO_0032296 GO:0032295 biolink:BiologicalProcess ensheathment of neuronal cell bodies The process in which satellite glial cells isolate neuronal cell bodies. go.json http://purl.obolibrary.org/obo/GO_0032295 GO:0032283 biolink:CellularComponent plastid acetate CoA-transferase complex An acetate CoA-transferase complex located in the stroma of a plastid. go.json http://purl.obolibrary.org/obo/GO_0032283 GO:0032282 biolink:CellularComponent plastid acetyl-CoA carboxylase complex An acetyl-CoA carboxylase complex located in the stroma of a plastid. go.json plastid ACCase complex http://purl.obolibrary.org/obo/GO_0032282 GO:0032281 biolink:CellularComponent AMPA glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. go.json AMPA receptor|AMPA-selective glutamate receptor complex|alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex http://purl.obolibrary.org/obo/GO_0032281 GO:0032280 biolink:CellularComponent symmetric synapse A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory. go.json Gray's type II synapse http://purl.obolibrary.org/obo/GO_0032280 GO:0032289 biolink:BiologicalProcess central nervous system myelin formation The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system. go.json central nervous system myelin sheath formation|myelin formation in central nervous system http://purl.obolibrary.org/obo/GO_0032289 GO:0032288 biolink:BiologicalProcess myelin assembly The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. go.json myelin formation|myelin sheath assembly http://purl.obolibrary.org/obo/GO_0032288 GO:0032287 biolink:BiologicalProcess peripheral nervous system myelin maintenance The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state. go.json myelin maintenance in peripheral nervous system|peripheral nervous system myelin sheath maintenance http://purl.obolibrary.org/obo/GO_0032287 GO:0032286 biolink:BiologicalProcess central nervous system myelin maintenance The process in which the structure and material content of mature central nervous system myelin is kept in a functional state. go.json central nervous system myelin sheath maintenance|myelin maintenance in central nervous system http://purl.obolibrary.org/obo/GO_0032286 GO:0032285 biolink:BiologicalProcess non-myelinated axon ensheathment The process in which a non-myelinating glial cell membrane closes around an axon. go.json ensheathment of non-myelinated axons http://purl.obolibrary.org/obo/GO_0032285 GO:0032284 biolink:CellularComponent obsolete plastid biotin carboxylase complex OBSOLETE. A biotin carboxylase complex located in the stroma of a plastid. go.json True http://purl.obolibrary.org/obo/GO_0032284 GO:0071880 biolink:BiologicalProcess adenylate cyclase-activating adrenergic receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. go.json activation of adenylate cyclase activity by adrenergic receptor signaling pathway|activation of adenylate cyclase activity by adrenergic receptor signalling pathway|adrenergic receptor, adenylate cyclase activating pathway|adrenergic receptor, adenylyl cyclase activating pathway http://purl.obolibrary.org/obo/GO_0071880 GO:1900759 biolink:BiologicalProcess positive regulation of D-amino-acid oxidase activity Any process that activates or increases the frequency, rate or extent of D-amino-acid oxidase activity. go.json activation of D-amino-acid oxidase activity|activation of D-amino-acid:oxygen oxidoreductase (deaminating)|activation of L-amino acid:O2 oxidoreductase activity|activation of new yellow enzyme|positive regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|positive regulation of L-amino acid:O2 oxidoreductase activity|positive regulation of new yellow enzyme|up regulation of D-amino-acid oxidase activity|up regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|up regulation of L-amino acid:O2 oxidoreductase activity|up regulation of new yellow enzyme|up-regulation of D-amino-acid oxidase activity|up-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|up-regulation of L-amino acid:O2 oxidoreductase activity|up-regulation of new yellow enzyme|upregulation of D-amino-acid oxidase activity|upregulation of D-amino-acid:oxygen oxidoreductase (deaminating)|upregulation of L-amino acid:O2 oxidoreductase activity|upregulation of new yellow enzyme http://purl.obolibrary.org/obo/GO_1900759 gocheck_do_not_annotate GO:1900756 biolink:BiologicalProcess protein processing in phagocytic vesicle Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation. go.json peptidolysis during protein maturation in phagocytic vesicle|peptidolysis during protein maturation in phagosome|protein maturation by peptide bond cleavage in phagocytic vesicle|protein maturation by peptide bond cleavage in phagosome|protein maturation by peptide bond hydrolysis in phagocytic vesicle|protein maturation by peptide bond hydrolysis in phagosome|protein maturation by proteolysis in phagocytic vesicle|protein maturation by proteolysis in phagosome|protein processing in phagosome http://purl.obolibrary.org/obo/GO_1900756 GO:1900755 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900755 GO:1900758 biolink:BiologicalProcess negative regulation of D-amino-acid oxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity. go.json down regulation of D-amino-acid oxidase activity|down regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|down regulation of L-amino acid:O2 oxidoreductase activity|down regulation of new yellow enzyme|down-regulation of D-amino-acid oxidase activity|down-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|down-regulation of L-amino acid:O2 oxidoreductase activity|down-regulation of new yellow enzyme|downregulation of D-amino-acid oxidase activity|downregulation of D-amino-acid:oxygen oxidoreductase (deaminating)|downregulation of L-amino acid:O2 oxidoreductase activity|downregulation of new yellow enzyme|inhibition of D-amino-acid oxidase activity|inhibition of D-amino-acid:oxygen oxidoreductase (deaminating)|inhibition of L-amino acid:O2 oxidoreductase activity|inhibition of new yellow enzyme|negative regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|negative regulation of L-amino acid:O2 oxidoreductase activity|negative regulation of new yellow enzyme http://purl.obolibrary.org/obo/GO_1900758 gocheck_do_not_annotate GO:1900757 biolink:BiologicalProcess regulation of D-amino-acid oxidase activity Any process that modulates the frequency, rate or extent of D-amino-acid oxidase activity. go.json regulation of D-amino-acid:oxygen oxidoreductase (deaminating)|regulation of L-amino acid:O2 oxidoreductase activity|regulation of new yellow enzyme http://purl.obolibrary.org/obo/GO_1900757 gocheck_do_not_annotate GO:1900752 biolink:BiologicalProcess malonic acid transport The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json C3H4O4 transport|H2malo transport|HOOC-CH2-COOH transport|propanedioic acid transport http://purl.obolibrary.org/obo/GO_1900752 GO:1900751 biolink:BiologicalProcess 4-(trimethylammonio)butanoate transport The directed movement of a 4-(trimethylammonio)butanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json 4-(N-trimethylamino)butyrate transport|4-butyrobetaine transport|Actinine transport|C7H15NO2 transport|butyrobetaine transport|deoxycarnitine transport|gamma-Butyrobetain transport|gamma-butyrobetaine transport http://purl.obolibrary.org/obo/GO_1900751 GO:1900754 biolink:BiologicalProcess 4-hydroxyphenylacetate transport The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json (4-hydroxyphenyl)acetate transport|(p-hydroxyphenyl)acetate transport|2-(4-hydroxyphenyl)ethanoate transport|4-hydroxybenzeneacetate transport http://purl.obolibrary.org/obo/GO_1900754 GO:1900753 biolink:BiologicalProcess doxorubicin transport The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. go.json (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport|(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport|(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione transport|14-hydroxydaunomycin transport|14-hydroxydaunorubicine transport|Adriamycin transport|doxorubicine transport|doxorubicinum transport http://purl.obolibrary.org/obo/GO_1900753 GO:1900750 biolink:MolecularActivity oligopeptide binding Binding to an oligopeptide. go.json Oligopeptid binding|oligopeptides binding|oligopeptido binding http://purl.obolibrary.org/obo/GO_1900750 GO:0140062 biolink:MolecularActivity 5-formylcytosine dioxygenase activity Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2. go.json 5fC dioxygenase http://purl.obolibrary.org/obo/GO_0140062 GO:0140065 biolink:MolecularActivity peptide butyryltransferase activity Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide. RHEA:53912 go.json protein butyryltransferase activity http://purl.obolibrary.org/obo/GO_0140065 GO:0140064 biolink:MolecularActivity peptide crotonyltransferase activity Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide. RHEA:53908 go.json protein crotonyltransferase activity http://purl.obolibrary.org/obo/GO_0140064 GO:0140067 biolink:BiologicalProcess peptidyl-lysine butyrylation The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid. go.json http://purl.obolibrary.org/obo/GO_0140067 gocheck_do_not_annotate GO:0140066 biolink:BiologicalProcess peptidyl-lysine crotonylation The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid. go.json http://purl.obolibrary.org/obo/GO_0140066 gocheck_do_not_annotate GO:0140069 biolink:MolecularActivity histone butyryltransferase activity Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone. go.json http://purl.obolibrary.org/obo/GO_0140069 GO:0140068 biolink:MolecularActivity histone crotonyltransferase activity Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone. go.json http://purl.obolibrary.org/obo/GO_0140068 GO:0071889 biolink:MolecularActivity 14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. go.json http://purl.obolibrary.org/obo/GO_0071889 GO:0071888 biolink:BiologicalProcess macrophage apoptotic process Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. go.json AICD|activation-induced cell death|macrophage apoptosis http://purl.obolibrary.org/obo/GO_0071888 GO:0071887 biolink:BiologicalProcess leukocyte apoptotic process Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. go.json leukocyte apoptosis http://purl.obolibrary.org/obo/GO_0071887 GO:0071886 biolink:MolecularActivity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug. go.json (+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding|1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding|4-iodo-2,5-dimethoxyphenylisopropylamine binding http://purl.obolibrary.org/obo/GO_0071886 GO:0071885 biolink:MolecularActivity N-terminal protein N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. EC:2.1.1.244 go.json X-Pro-Lys N-terminal methyltransferase http://purl.obolibrary.org/obo/GO_0071885 GO:0071884 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0071884 GO:0071883 biolink:BiologicalProcess MAPK-activating adrenergic receptor signaling pathway The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade. go.json activation of MAP kinase activity by adrenergic receptor signaling pathway|activation of MAP kinase activity by adrenergic receptor signalling pathway|activation of MAPK activity by adrenergic receptor signaling pathway|activation of MAPK activity by adrenergic receptor signalling pathway http://purl.obolibrary.org/obo/GO_0071883 GO:0071882 biolink:BiologicalProcess phospholipase C-activating adrenergic receptor signaling pathway A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. go.json activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signalling pathway|adrenergic receptor, phospholipase C activating pathway http://purl.obolibrary.org/obo/GO_0071882 GO:0140061 biolink:MolecularActivity 5-hydroxymethylcytosine dioxygenase activity Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2. go.json 5hmC dioxygenase http://purl.obolibrary.org/obo/GO_0140061 GO:0071881 biolink:BiologicalProcess adenylate cyclase-inhibiting adrenergic receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process. go.json adrenergic receptor, adenylate cyclase inhibiting pathway|adrenergic receptor, adenylyl cyclase inhibiting pathway|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway http://purl.obolibrary.org/obo/GO_0071881 GO:0140060 biolink:BiologicalProcess axon arborization The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches. go.json http://purl.obolibrary.org/obo/GO_0140060 GO:1900767 biolink:BiologicalProcess fonsecin metabolic process The chemical reactions and pathways involving fonsecin. go.json fonsecin metabolism http://purl.obolibrary.org/obo/GO_1900767 GO:1900766 biolink:BiologicalProcess emericellin biosynthetic process The chemical reactions and pathways resulting in the formation of emericellin. go.json Variecoxanthone B anabolism|Variecoxanthone B biosynthesis|Variecoxanthone B biosynthetic process|Variecoxanthone B formation|Variecoxanthone B synthesis|emericellin anabolism|emericellin biosynthesis|emericellin formation|emericellin synthesis http://purl.obolibrary.org/obo/GO_1900766 GO:1900769 biolink:BiologicalProcess fonsecin biosynthetic process The chemical reactions and pathways resulting in the formation of fonsecin. go.json fonsecin anabolism|fonsecin biosynthesis|fonsecin formation|fonsecin synthesis http://purl.obolibrary.org/obo/GO_1900769 GO:1900768 biolink:BiologicalProcess fonsecin catabolic process The chemical reactions and pathways resulting in the breakdown of fonsecin. go.json fonsecin breakdown|fonsecin catabolism|fonsecin degradation http://purl.obolibrary.org/obo/GO_1900768 GO:1900763 biolink:BiologicalProcess averantin biosynthetic process The chemical reactions and pathways resulting in the formation of averantin. go.json averantin anabolism|averantin biosynthesis|averantin formation|averantin synthesis http://purl.obolibrary.org/obo/GO_1900763 GO:0140059 biolink:BiologicalProcess dendrite arborization The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches. go.json http://purl.obolibrary.org/obo/GO_0140059 GO:1900762 biolink:BiologicalProcess averantin catabolic process The chemical reactions and pathways resulting in the breakdown of averantin. go.json averantin breakdown|averantin catabolism|averantin degradation http://purl.obolibrary.org/obo/GO_1900762 GO:1900765 biolink:BiologicalProcess emericellin catabolic process The chemical reactions and pathways resulting in the breakdown of emericellin. go.json Variecoxanthone B breakdown|Variecoxanthone B catabolic process|Variecoxanthone B catabolism|Variecoxanthone B degradation|emericellin breakdown|emericellin catabolism|emericellin degradation http://purl.obolibrary.org/obo/GO_1900765 GO:1900764 biolink:BiologicalProcess emericellin metabolic process The chemical reactions and pathways involving emericellin. go.json Variecoxanthone B metabolic process|Variecoxanthone B metabolism|emericellin metabolism http://purl.obolibrary.org/obo/GO_1900764 GO:1900761 biolink:BiologicalProcess averantin metabolic process The chemical reactions and pathways involving averantin. go.json averantin metabolism http://purl.obolibrary.org/obo/GO_1900761 GO:1900760 biolink:BiologicalProcess negative regulation of sterigmatocystin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process. go.json down regulation of sterigmatocystin anabolism|down regulation of sterigmatocystin biosynthesis|down regulation of sterigmatocystin biosynthetic process|down regulation of sterigmatocystin formation|down regulation of sterigmatocystin synthesis|down-regulation of sterigmatocystin anabolism|down-regulation of sterigmatocystin biosynthesis|down-regulation of sterigmatocystin biosynthetic process|down-regulation of sterigmatocystin formation|down-regulation of sterigmatocystin synthesis|downregulation of sterigmatocystin anabolism|downregulation of sterigmatocystin biosynthesis|downregulation of sterigmatocystin biosynthetic process|downregulation of sterigmatocystin formation|downregulation of sterigmatocystin synthesis|inhibition of sterigmatocystin anabolism|inhibition of sterigmatocystin biosynthesis|inhibition of sterigmatocystin biosynthetic process|inhibition of sterigmatocystin formation|inhibition of sterigmatocystin synthesis|negative regulation of sterigmatocystin anabolism|negative regulation of sterigmatocystin biosynthesis|negative regulation of sterigmatocystin formation|negative regulation of sterigmatocystin synthesis http://purl.obolibrary.org/obo/GO_1900760 GO:0140052 biolink:BiologicalProcess cellular response to oxidised low-density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus. go.json cellular response to ox-LDL particle stimulus|cellular response to oxLDL particle stimulus|cellular response to oxidised LDL particle stimulus|cellular response to oxidized LDL particle stimulus|cellular response to oxidized low-density lipoprotein particle stimulus http://purl.obolibrary.org/obo/GO_0140052 GO:0140051 biolink:BiologicalProcess positive regulation of endocardial cushion to mesenchymal transition Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition. go.json http://purl.obolibrary.org/obo/GO_0140051 GO:0140053 biolink:BiologicalProcess mitochondrial gene expression The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. go.json http://purl.obolibrary.org/obo/GO_0140053 goslim_generic|goslim_pombe GO:0140056 biolink:BiologicalProcess organelle localization by membrane tethering The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. go.json http://purl.obolibrary.org/obo/GO_0140056 goslim_pombe GO:0071879 biolink:BiologicalProcess positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. go.json positive regulation of adrenergic receptor signaling pathway|positive regulation of adrenergic receptor signalling pathway http://purl.obolibrary.org/obo/GO_0071879 GO:0140058 biolink:BiologicalProcess neuron projection arborization The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites. go.json branching morphogenesis of a neurite|branching morphogenesis of a neuron projection|neurite arborization|neurite branching|neuron projection branching http://purl.obolibrary.org/obo/GO_0140058 GO:0140057 biolink:BiologicalProcess vacuole-mitochondria membrane tethering The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. go.json http://purl.obolibrary.org/obo/GO_0140057 GO:0071878 biolink:BiologicalProcess negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. go.json negative regulation of adrenergic receptor signaling pathway|negative regulation of adrenergic receptor signalling pathway http://purl.obolibrary.org/obo/GO_0071878 GO:0071877 biolink:BiologicalProcess regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. go.json regulation of adrenergic receptor signaling pathway|regulation of adrenergic receptor signalling pathway http://purl.obolibrary.org/obo/GO_0071877 GO:0071876 biolink:BiologicalProcess obsolete initiation of adrenergic receptor signal transduction OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor. go.json initiation of adrenergic receptor signal transduction True http://purl.obolibrary.org/obo/GO_0071876 GO:0071875 biolink:BiologicalProcess adrenergic receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. go.json adrenergic receptor signalling pathway|adrenoceptor signaling pathway http://purl.obolibrary.org/obo/GO_0071875 GO:0071874 biolink:BiologicalProcess cellular response to norepinephrine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. go.json cellular response to noradrenaline stimulus http://purl.obolibrary.org/obo/GO_0071874 GO:0022900 biolink:BiologicalProcess electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. Wikipedia:Electron_transport_chain go.json http://purl.obolibrary.org/obo/GO_0022900 goslim_pir GO:0071873 biolink:BiologicalProcess response to norepinephrine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. go.json response to noradrenaline stimulus|response to norepinephrine stimulus http://purl.obolibrary.org/obo/GO_0071873 GO:0071872 biolink:BiologicalProcess cellular response to epinephrine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. go.json cellular response to adrenaline stimulus http://purl.obolibrary.org/obo/GO_0071872 GO:0071871 biolink:BiologicalProcess response to epinephrine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. go.json response to adrenaline stimulus|response to epinephrine stimulus http://purl.obolibrary.org/obo/GO_0071871 GO:0140050 biolink:BiologicalProcess negative regulation of endocardial cushion to mesenchymal transition Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition. go.json http://purl.obolibrary.org/obo/GO_0140050 GO:0071870 biolink:BiologicalProcess cellular response to catecholamine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. go.json http://purl.obolibrary.org/obo/GO_0071870 GO:0022904 biolink:BiologicalProcess respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. Wikipedia:Electron_transfer go.json 6-phosphofructokinase reduction|dihydrobiopterin reduction|dihydrolipoamide reduction|dihydrolipoylprotein reduction|dihydropteridine reduction|electron transfer|other pathways of electron transport|oxidized glutathione reduction|protein-disulfide reduction http://purl.obolibrary.org/obo/GO_0022904 GO:1900778 biolink:BiologicalProcess obsolete fumiquinazoline A biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of fumiquinazoline A. go.json fumiquinazoline A anabolism|fumiquinazoline A biosynthesis|fumiquinazoline A formation|fumiquinazoline A synthesis True http://purl.obolibrary.org/obo/GO_1900778 GO:1900777 biolink:BiologicalProcess obsolete fumiquinazoline A catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline A. go.json fumiquinazoline A breakdown|fumiquinazoline A catabolism|fumiquinazoline A degradation True http://purl.obolibrary.org/obo/GO_1900777 GO:1900779 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900779 GO:1900774 biolink:BiologicalProcess obsolete fumiquinazoline catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline. go.json fumiquinazoline breakdown|fumiquinazoline catabolism|fumiquinazoline degradation|fumiquinazolines breakdown|fumiquinazolines catabolic process|fumiquinazolines catabolism|fumiquinazolines degradation True http://purl.obolibrary.org/obo/GO_1900774 GO:1900773 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900773 GO:1900776 biolink:BiologicalProcess obsolete fumiquinazoline A metabolic process OBSOLETE. The chemical reactions and pathways involving fumiquinazoline A. go.json fumiquinazoline A metabolism True http://purl.obolibrary.org/obo/GO_1900776 GO:1900775 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900775 GO:1900770 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900770 GO:1900772 biolink:BiologicalProcess fumitremorgin B biosynthetic process The chemical reactions and pathways resulting in the formation of the indole alkaloid fumitremorgin B. go.json Lanosulin anabolism|Lanosulin biosynthesis|Lanosulin biosynthetic process|Lanosulin formation|Lanosulin metabolic process|Lanosulin metabolism|Lanosulin synthesis|fumitremorgin B anabolism|fumitremorgin B biosynthesis|fumitremorgin B formation|fumitremorgin B metabolic process|fumitremorgin B metabolism|fumitremorgin B synthesis http://purl.obolibrary.org/obo/GO_1900772 GO:1900771 biolink:BiologicalProcess obsolete fumitremorgin B catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumitremorgin B. go.json Lanosulin breakdown|Lanosulin catabolic process|Lanosulin catabolism|Lanosulin degradation|fumitremorgin B breakdown|fumitremorgin B catabolism|fumitremorgin B degradation True http://purl.obolibrary.org/obo/GO_1900771 GO:0140084 biolink:BiologicalProcess sexual macrocyst formation The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum. go.json macrocyst formation|sexual fusion http://purl.obolibrary.org/obo/GO_0140084 GO:0140081 biolink:MolecularActivity glycosylated region protein binding Binding to a glycosylated region of a protein. go.json http://purl.obolibrary.org/obo/GO_0140081 GO:0140080 biolink:MolecularActivity class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH. Wikipedia:AP_endonuclease go.json endonuclease III|endonuclease IV http://purl.obolibrary.org/obo/GO_0140080 GO:0140083 biolink:MolecularActivity ATP-dependent protein-DNA unloader activity Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction. go.json ATP-dependent protein-DNA unloading activity|protein-DNA unloading ATPase activity http://purl.obolibrary.org/obo/GO_0140083 GO:0140082 biolink:MolecularActivity SUMO-ubiquitin ligase activity Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. go.json http://purl.obolibrary.org/obo/GO_0140082 GO:0071891 biolink:BiologicalProcess N-terminal peptidyl-proline dimethylation involved in translation An N-terminal peptidyl-proline dimethylation process that contributes to translation. go.json http://purl.obolibrary.org/obo/GO_0071891 gocheck_do_not_annotate GO:0071890 biolink:MolecularActivity bicarbonate binding Binding to bicarbonate ions (CHO3-). go.json CHO3- ion binding binding|hydrogencarbonate binding http://purl.obolibrary.org/obo/GO_0071890 GO:1900789 biolink:BiologicalProcess pseurotin A catabolic process The chemical reactions and pathways resulting in the breakdown of pseurotin A. go.json Pseurotin breakdown|Pseurotin catabolic process|Pseurotin catabolism|Pseurotin degradation|pseurotin A breakdown|pseurotin A catabolism|pseurotin A degradation http://purl.obolibrary.org/obo/GO_1900789 GO:1900788 biolink:BiologicalProcess pseurotin A metabolic process The chemical reactions and pathways involving pseurotin A. go.json Pseurotin metabolic process|Pseurotin metabolism|pseurotin A metabolism http://purl.obolibrary.org/obo/GO_1900788 GO:1900785 biolink:BiologicalProcess naphtho-gamma-pyrone metabolic process The chemical reactions and pathways involving naphtho-gamma-pyrone. go.json naphtho-gamma-pyrone metabolism|naphtho-gamma-pyrones metabolic process|naphtho-gamma-pyrones metabolism http://purl.obolibrary.org/obo/GO_1900785 GO:1900784 biolink:BiologicalProcess obsolete fumiquinazoline F biosynthetic process OBSOLETE. The chemical reactions and pathways resulting in the formation of fumiquinazoline F. go.json fumiquinazoline F anabolism|fumiquinazoline F biosynthesis|fumiquinazoline F formation|fumiquinazoline F synthesis True http://purl.obolibrary.org/obo/GO_1900784 GO:1900787 biolink:BiologicalProcess naphtho-gamma-pyrone biosynthetic process The chemical reactions and pathways resulting in the formation of naphtho-gamma-pyrone. go.json naphtho-gamma-pyrone anabolism|naphtho-gamma-pyrone biosynthesis|naphtho-gamma-pyrone formation|naphtho-gamma-pyrone synthesis|naphtho-gamma-pyrones anabolism|naphtho-gamma-pyrones biosynthesis|naphtho-gamma-pyrones biosynthetic process|naphtho-gamma-pyrones formation|naphtho-gamma-pyrones synthesis http://purl.obolibrary.org/obo/GO_1900787 GO:1900786 biolink:BiologicalProcess naphtho-gamma-pyrone catabolic process The chemical reactions and pathways resulting in the breakdown of naphtho-gamma-pyrone. go.json naphtho-gamma-pyrone breakdown|naphtho-gamma-pyrone catabolism|naphtho-gamma-pyrone degradation|naphtho-gamma-pyrones breakdown|naphtho-gamma-pyrones catabolic process|naphtho-gamma-pyrones catabolism|naphtho-gamma-pyrones degradation http://purl.obolibrary.org/obo/GO_1900786 GO:1900781 biolink:BiologicalProcess fumiquinazoline C biosynthetic process The chemical reactions and pathways resulting in the formation of the indole alkaloid fumiquinazoline C. go.json fumiquinazoline C anabolism|fumiquinazoline C biosynthesis|fumiquinazoline C formation|fumiquinazoline C metabolic process|fumiquinazoline C metabolism|fumiquinazoline C synthesis|fumiquinazoline biosynthesis|fumiquinazoline biosynthetic process|fumiquinazoline metabolic process|fumiquinazoline metabolism|fumiquinazolines synthesis http://purl.obolibrary.org/obo/GO_1900781 GO:1900780 biolink:BiologicalProcess obsolete fumiquinazoline C catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline C. go.json fumiquinazoline C breakdown|fumiquinazoline C catabolism|fumiquinazoline C degradation True http://purl.obolibrary.org/obo/GO_1900780 GO:1900783 biolink:BiologicalProcess obsolete fumiquinazoline F catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline F. go.json fumiquinazoline F breakdown|fumiquinazoline F catabolism|fumiquinazoline F degradation True http://purl.obolibrary.org/obo/GO_1900783 GO:1900782 biolink:BiologicalProcess obsolete fumiquinazoline F metabolic process OBSOLETE. The chemical reactions and pathways involving fumiquinazoline F. go.json fumiquinazoline F metabolism True http://purl.obolibrary.org/obo/GO_1900782 GO:0140074 biolink:BiologicalProcess cardiac endothelial to mesenchymal transition A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes. go.json EndMT|EndoMT http://purl.obolibrary.org/obo/GO_0140074 GO:1900790 biolink:BiologicalProcess pseurotin A biosynthetic process The chemical reactions and pathways resulting in the formation of pseurotin A. go.json Pseurotin anabolism|Pseurotin biosynthesis|Pseurotin biosynthetic process|Pseurotin formation|Pseurotin synthesis|pseurotin A anabolism|pseurotin A biosynthesis|pseurotin A formation|pseurotin A synthesis http://purl.obolibrary.org/obo/GO_1900790 GO:0140076 biolink:BiologicalProcess negative regulation of lipoprotein transport Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport. go.json http://purl.obolibrary.org/obo/GO_0140076 GO:0140075 biolink:BiologicalProcess regulation of lipoprotein transport Any process that controls lipoprotein transport. go.json http://purl.obolibrary.org/obo/GO_0140075 GO:0140078 biolink:MolecularActivity class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. EC:4.2.99.18|MetaCyc:4.2.99.18-RXN|RHEA:66592|Wikipedia:AP_endonuclease go.json AP endonuclease class I activity|AP site-DNA 5'-phosphomonoester-lyase activity|DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity|DNA-(apurinic or apyrimidinic site) lyase activity|class I DNA-(apurinic or apyrimidinic site) lyase activity http://purl.obolibrary.org/obo/GO_0140078 GO:0140077 biolink:BiologicalProcess positive regulation of lipoprotein transport Any process that activates or increases the rate or extent of lipoprotein transport. go.json http://purl.obolibrary.org/obo/GO_0140077 GO:0140079 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140079 GO:0071899 biolink:BiologicalProcess obsolete negative regulation of estrogen receptor binding OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor. go.json True http://purl.obolibrary.org/obo/GO_0071899 GO:0071898 biolink:BiologicalProcess obsolete regulation of estrogen receptor binding OBSOLETE. Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor. go.json True http://purl.obolibrary.org/obo/GO_0071898 GO:0071897 biolink:BiologicalProcess DNA biosynthetic process The biosynthetic process resulting in the formation of DNA. go.json DNA anabolism|DNA biosynthesis|DNA formation|DNA synthesis http://purl.obolibrary.org/obo/GO_0071897 GO:0071896 biolink:BiologicalProcess protein localization to adherens junction Any process in which a protein is transported to, and/or maintained at the adherens junction. go.json protein localisation in adherens junction|protein localisation in cell-cell adherens junction|protein localisation to adherens junction|protein localisation to cell-cell adherens junction|protein localization in adherens junction|protein localization in cell-cell adherens junction|protein localization to cell-cell adherens junction http://purl.obolibrary.org/obo/GO_0071896 GO:0071895 biolink:BiologicalProcess odontoblast differentiation The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin. go.json http://purl.obolibrary.org/obo/GO_0071895 GO:0140070 biolink:MolecularActivity hydrogen peroxide channel activity Enables the transfer of hydrogen peroxide from one side of a membrane to the other. go.json hydrogen peroxide transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0140070 GO:0071894 biolink:BiologicalProcess histone H2B conserved C-terminal lysine ubiquitination A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals. go.json budding yeast H2B K123 ubiquitination|fission yeast H2B K119 ubiquitination|mammalian H2B K120 ubiquitination http://purl.obolibrary.org/obo/GO_0071894 gocheck_do_not_annotate GO:0071893 biolink:BiologicalProcess obsolete BMP signaling pathway involved in nephric duct formation OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to nephric duct formation. go.json BMP signalling pathway involved in nephric duct formation True http://purl.obolibrary.org/obo/GO_0071893 GO:0071892 biolink:BiologicalProcess thrombocyte activation A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals. go.json blood coagulation, thrombocyte activation http://purl.obolibrary.org/obo/GO_0071892 GO:1900799 biolink:BiologicalProcess cordyol C biosynthetic process The chemical reactions and pathways resulting in the formation of cordyol C. go.json cordyol C anabolism|cordyol C biosynthesis|cordyol C formation|cordyol C synthesis http://purl.obolibrary.org/obo/GO_1900799 GO:1900796 biolink:BiologicalProcess terrequinone A biosynthetic process The chemical reactions and pathways resulting in the formation of terrequinone A. go.json terrequinone A anabolism|terrequinone A biosynthesis|terrequinone A formation|terrequinone A metabolic process|terrequinone A metabolism|terrequinone A synthesis http://purl.obolibrary.org/obo/GO_1900796 GO:0140027 biolink:BiologicalProcess contractile vacuole localization The directed movement of the contractile vacuole to a specific location. go.json establishment of contractile vacuole localization http://purl.obolibrary.org/obo/GO_0140027 GO:1900795 biolink:BiologicalProcess obsolete terrequinone A catabolic process OBSOLETE. The chemical reactions and pathways resulting in the breakdown of terrequinone A. go.json terrequinone A breakdown|terrequinone A catabolism|terrequinone A degradation True http://purl.obolibrary.org/obo/GO_1900795 GO:0140026 biolink:BiologicalProcess contractile vacuole dissociation from plasma membrane The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network. go.json contractile vacuole detethering from plasma membrane http://purl.obolibrary.org/obo/GO_0140026 GO:1900798 biolink:BiologicalProcess cordyol C catabolic process The chemical reactions and pathways resulting in the breakdown of cordyol C. go.json cordyol C breakdown|cordyol C catabolism|cordyol C degradation http://purl.obolibrary.org/obo/GO_1900798 GO:0140029 biolink:BiologicalProcess exocytic process The cellular processes that contribute to exocytosis. go.json http://purl.obolibrary.org/obo/GO_0140029 gocheck_do_not_annotate GO:1900797 biolink:BiologicalProcess cordyol C metabolic process The chemical reactions and pathways involving cordyol C. go.json cordyol C metabolism http://purl.obolibrary.org/obo/GO_1900797 GO:0140028 biolink:BiologicalProcess pore formation during contractile vacuole discharge The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes. go.json http://purl.obolibrary.org/obo/GO_0140028 GO:1900792 biolink:BiologicalProcess shamixanthone catabolic process The chemical reactions and pathways resulting in the breakdown of shamixanthone. go.json shamixanthone breakdown|shamixanthone catabolism|shamixanthone degradation http://purl.obolibrary.org/obo/GO_1900792 GO:1900791 biolink:BiologicalProcess shamixanthone metabolic process The chemical reactions and pathways involving shamixanthone. go.json shamixanthone metabolism http://purl.obolibrary.org/obo/GO_1900791 GO:1900794 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_1900794 GO:1900793 biolink:BiologicalProcess shamixanthone biosynthetic process The chemical reactions and pathways resulting in the formation of shamixanthone. go.json shamixanthone anabolism|shamixanthone biosynthesis|shamixanthone formation|shamixanthone synthesis http://purl.obolibrary.org/obo/GO_1900793 GO:0140021 biolink:BiologicalProcess mitochondrial ADP transmembrane transport The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion. go.json http://purl.obolibrary.org/obo/GO_0140021 GO:0140020 biolink:CellularComponent DNA methyltransferase complex A protein complex that possesses DNA methyltransferase activity. go.json http://purl.obolibrary.org/obo/GO_0140020 GO:0140023 biolink:BiologicalProcess tRNA adenosine deamination to inosine The removal of an amine group from an adenosine to produce inosine within a tRNA molecule. go.json A-to-I tRNA editing http://purl.obolibrary.org/obo/GO_0140023 GO:0140022 biolink:CellularComponent cnida A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria. go.json cnidae (plural) http://purl.obolibrary.org/obo/GO_0140022 GO:0140025 biolink:BiologicalProcess contractile vacuole tethering involved in discharge The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. go.json contractile vacuole tethering to plasma membrane http://purl.obolibrary.org/obo/GO_0140025 GO:0140024 biolink:BiologicalProcess plus-end-directed endosome transport along mitotic spindle midzone microtubule The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination. go.json http://purl.obolibrary.org/obo/GO_0140024 GO:0140016 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140016 GO:0140018 biolink:BiologicalProcess regulation of cytoplasmic translational fidelity Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code. go.json http://purl.obolibrary.org/obo/GO_0140018 GO:0140010 biolink:MolecularActivity D-aspartate transmembrane transporter activity Enables the transfer of D-aspartate from one side of a membrane to the other. go.json http://purl.obolibrary.org/obo/GO_0140010 GO:0140014 biolink:BiologicalProcess mitotic nuclear division A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. go.json mitosis http://purl.obolibrary.org/obo/GO_0140014 goslim_chembl|goslim_generic GO:0140013 biolink:BiologicalProcess meiotic nuclear division One of the two nuclear divisions that occur as part of the meiotic cell cycle. go.json meiosis http://purl.obolibrary.org/obo/GO_0140013 goslim_generic GO:0140049 biolink:BiologicalProcess regulation of endocardial cushion to mesenchymal transition Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition. go.json http://purl.obolibrary.org/obo/GO_0140049 GO:0140048 biolink:BiologicalProcess manganese ion export across plasma membrane The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region. go.json manganese ion export from cell http://purl.obolibrary.org/obo/GO_0140048 GO:0140041 biolink:BiologicalProcess cellular detoxification of methylglyoxal Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. These may include chemical modification or transport of methylglyoxal away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. go.json http://purl.obolibrary.org/obo/GO_0140041 GO:0140040 biolink:BiologicalProcess mitochondrial polycistronic RNA processing The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs. go.json http://purl.obolibrary.org/obo/GO_0140040 GO:0140043 biolink:BiologicalProcess lipid droplet localization to prospore membrane leading edge Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge. go.json adiposome localization to FSM membrane leading edge|adiposome localization to ascospore-type prospore membrane leading edge|adiposome localization to forespore membrane leading edge|lipid body localization to FSM membrane leading edge|lipid body localization to ascospore-type prospore membrane leading edge|lipid body localization to forespore membrane leading edge|lipid particle localization to FSM membrane leading edge|lipid particle localization to ascospore-type prospore membrane leading edge|lipid particle localization to forespore membrane leading edge http://purl.obolibrary.org/obo/GO_0140043 GO:0140042 biolink:BiologicalProcess lipid droplet formation A process that results in the assembly, arrangement of constituent parts of a lipid droplet. go.json adiposome formation|lipid body formation|lipid particle formation http://purl.obolibrary.org/obo/GO_0140042 GO:0140045 biolink:OntologyClass go.json True http://purl.obolibrary.org/obo/GO_0140045 GO:0140037 biolink:MolecularActivity sumo-dependent protein binding Binding to a protein upon sumoylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140037 GO:0140039 biolink:BiologicalProcess cell-cell adhesion in response to extracellular stimulus The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus. go.json http://purl.obolibrary.org/obo/GO_0140039 GO:0140030 biolink:MolecularActivity modification-dependent protein binding Binding to a protein upon post-translation modification of the target protein. go.json modified protein binding http://purl.obolibrary.org/obo/GO_0140030 GO:0140032 biolink:MolecularActivity glycosylation-dependent protein binding Binding to a protein upon glycosylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140032 GO:0140031 biolink:MolecularActivity phosphorylation-dependent protein binding Binding to a protein upon phosphorylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140031 GO:0140034 biolink:MolecularActivity methylation-dependent protein binding Binding to a protein upon methylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140034 GO:0140033 biolink:MolecularActivity acetylation-dependent protein binding Binding to a protein upon acetylation of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140033 GO:0140036 biolink:MolecularActivity ubiquitin-dependent protein binding Binding to a protein upon ubiquitination of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140036 GO:0140035 biolink:MolecularActivity ubiquitination-like modification-dependent protein binding Binding to a protein upon modification by a ubiquitin-like protein of the target protein. go.json http://purl.obolibrary.org/obo/GO_0140035